gebhart/patrepeval huggingface dataset:
Matrix Metalloproteinase (MMP)-13 Regulates Mammary Tumor–Induced Osteolysis by Activating MMP9 and Transforming Growth Factor-β Signaling at the Tumor-Bone Interface (2010)

The tropism of breast cancer cells for bone and their tendency to induce an osteolytic phenotype are a result of interactions between breast cancer cells and stromal cells and are of paramount importance for bone metastasis. However, the underlying molecular mechanisms remain poorly understood. We hypothesize that tumor-stromal interaction alters gene expression in malignant tumor cells and stromal cells creating a unique expression signature that promotes osteolytic breast cancer bone metastasis and that inhibition of such interactions can be developed as targeted therapeutics. Microarray analysis was performed to investigate gene expression profiling at the tumor-bone (TB) interface versus the tumor alone area from syngenic mice injected with three different syngenic mammary tumor cell lines that differ in their metastatic potential. We identified matrix metalloproteinase 13 (MMP13), receptor activator of NF-kappaB ligand (RANKL), and integrins binding sialoprotein to be genes upregulated at the TB interface and validated. To determine the functional role of MMP13 in tumor-induced osteolysis, mice with Cl66 mammary tumors were treated with MMP13 antisense oligonucleotides (MMP13-ASO) or control scrambled oligonucleotides (control-ASO). Knockdown of MMP13 expression at the TB interface leads to significant reduction in bone destruction and in the number of activated osteoclasts at the TB interface. Further analysis to evaluate the mechanism of MMP13-dependent osteolytic bone metastasis revealed that MMP13-ASO treatment decreased active MMP9, RANKL levels, and transforming growth factor-beta signaling at the TB interface. Together, our data indicate that upregulation of MMP13 at the TB interface is important in tumor-induced osteolysis and suggest that MMP13 is a potential therapeutic target for breast cancer bone metastasis.
Genome-wide assessment of antimicrobial tolerance in Yersinia pseudotuberculosis under ciprofloxacin stress (2019)

<i>Yersinia pseudotuberculosis</i> is a Gram-negative bacterium capable of causing gastrointestinal infection and is closely related to the highly virulent plague bacillus <i>Yersinia pestis</i>. Infections by both species are currently treatable with antibiotics such as ciprofloxacin, a quinolone-class drug of major clinical importance in the treatment of many other infections. Our current understanding of the mechanism of action of ciprofloxacin is that it inhibits DNA replication by targeting DNA gyrase, and that resistance is primarily due to mutation of this target site, along with generic efflux and detoxification strategies. We utilized transposon-directed insertion site sequencing (TraDIS or TnSeq) to identify the non-essential chromosomal genes in <i>Y. pseudotuberculosis</i> that are required to tolerate sub-lethal concentrations of ciprofloxacin <i>in vitro</i>. As well as highlighting recognized antibiotic resistance genes, we provide evidence that multiple genes involved in regulating DNA replication and repair are central in enabling <i>Y. pseudotuberculosis</i> to tolerate the antibiotic, including DksA (yptb0734), a regulator of RNA polymerase, and Hda (yptb2792), an inhibitor of DNA replication initiation. We furthermore demonstrate that even at sub-lethal concentrations, ciprofloxacin causes severe cell-wall stress, requiring lipopolysaccharide lipid A, O-antigen and core biosynthesis genes to resist the sub-lethal effects of the antibiotic. It is evident that coping with the consequence(s) of antibiotic-induced stress requires the contribution of scores of genes that are not exclusively engaged in drug resistance.
The Basis for Adhesive Bond Design (2021)

No AccessAdhesion and Adhesives TechnologyMar 2021The Basis for Adhesive Bond DesignAlphonsus V. PociusAlphonsus V. Pociushttps://doi.org/10.3139/9781569908501.013SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2021Pages: 343-358Print ISBN: 978-1-56990-855-6eISBN: 978-1-56990-850-1 Copyright & Permissions© 2021 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
ChemInform Abstract: C‐Attached Aminoalkylindoles: Potent Cannabinoid Mimetics (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Oxidation of Glycerol to Glycolate by using Supported Gold and Palladium Nanoparticles (2009)

Glycolic acid is an important chemical that has uses as a cleaning agent as well as a chemical intermediate. At present glycolic acid is manufactured from either chloroacetic acid or from formaldehyde hydrocyanation, both routes being nongreen and using nonsustainable resources. We investigate the possibility of producing glycolate from the oxidation of glycerol, a sustainable raw material. We show that by using 1 % wt Au/carbon catalysts prepared using a sol-immobilization method glycolate yields of ca. 60 % can be achieved, using hydrogen peroxide as oxidant in an autoclave reactor. We describe and discuss the reaction mechanism and consider the reaction conditions that maximize the formation of glycolate.
Preemptable remote execution facilities for the V-system (1985)

Article Free Access Share on Preemptable remote execution facilities for the V-system Authors: Marvin M. Theimer Computer Science Department, Stanford University, Stanford, CA Computer Science Department, Stanford University, Stanford, CAView Profile , Keith A. Lantz Computer Science Department, Stanford University, Stanford, CA Computer Science Department, Stanford University, Stanford, CAView Profile , David R. Cheriton Computer Science Department, Stanford University, Stanford, CA Computer Science Department, Stanford University, Stanford, CAView Profile Authors Info & Claims SOSP '85: Proceedings of the tenth ACM symposium on Operating systems principlesDecember 1985 Pages 2–12https://doi.org/10.1145/323647.323629Published:01 December 1985Publication History 227citation736DownloadsMetricsTotal Citations227Total Downloads736Last 12 Months33Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Influence of Lateral Temperature Gradients on the Failure Modes at Power Cycling (2021)

In this article, the influence of the insulated gate bipolar transistor (IGBT) chip-near temperature gradient on the failure modes in the power cycling test is investigated with the finite element (FE) simulation and experiment. Two important aspects influencing the temperature gradient are studied: one is the load current pulse duration t <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</sub> from the testing aspect; the other is the area ratio between the chip region and direct copper bonding (DCB) top side copper determined by the device package layout. The IGBT chip-near temperature gradient caused by these two factors is first investigated using the FE thermal simulation. It was found that by varying t <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</sub> and the area ratio, a significant influence on the temperature gradient of the chip and the average temperature of the solder layer can be achieved, which could lead to different dominating failure modes under the same power cycling test conditions. Furthermore, experiments considering those two factors were designed and performed to verify the inference derived from the simulation. The results show that the failure mode indeed can be shifted because of the changed temperature gradient.
Efficient techniques for document sanitization (2008)

Sanitization of a document involves removing sensitive information from the document, so that it may be distributed to a broader audience. Such sanitization is needed while declassifying documents involving sensitive or confidential information such as corporate emails, intelligence reports, medical records, etc. In this paper, we present the ERASE framework for performing document sanitization in an automated manner. ERASE can be used to sanitize a document dynamically, so that different users get different views of the same document based on what they are authorized to know. We formalize the problem and present algorithms used in ERASE for finding the appropriate terms to remove from the document. Our preliminary experimental study demonstrates the efficiency and efficacy of the proposed algorithms.
High Power Factor Control Regulating Inverter Output Power in IPM Motor Driven by Inverter System without Electrolytic Capacitor (2011)

This paper presents a new high power factor control method for a single-to-three-phase power converter without an electrolytic capacitor. The circuit used in the method consists of a single-phase rectifier, a small film capacitor at DC-link, a voltage-source three-phase inverter, and an IPM motor. The inverter regulates both the velocity of the IPM motor and input current waveform. In order to obtain a power factor of unity, we propose a new control method that regulates the inverter output power. The inverter output power controller is placed between the speed controller and the q-axis current controller. The inverter power is regulated by a PI and repetitive controller. When repetitive control is applied to the inverter power controller, the phase delay of the inverter power controller is quite small. The superior performance of the proposed method is demonstrated by experimental results.
Supplementary Figure S1 from Potent siRNA Inhibitors of Ribonucleotide Reductase Subunit RRM2 Reduce Cell Proliferation <i>In vitro</i> and <i>In vivo</i> (2023)

Supplementary Figure S1 from Potent siRNA Inhibitors of Ribonucleotide Reductase Subunit RRM2 Reduce Cell Proliferation &lt;i&gt;In vitro&lt;/i&gt; and &lt;i&gt;In vivo&lt;/i&gt;
Zone melt texturing of YBa2Cu3O6+ with silver additions (1990)

Extruded YBa2Cu3O6+x wires containing 0 to 15 vol% silver have been textured by a zone melting process. It is observed that the magnetization critical current density in textured samples decreases with silver additions, unlike what is usually observed in sintered samples. In transport measurements, a Jc of 5500 A/cm2 in an applied field of 8000 Oe was observed in a sample containing 15 vol% silver.
Flames of Swirling Double-Concentric Jets Subject to Acoustic Excitation at Resonance (2018)

The effects of acoustic excitation at resonance on the flame appearances, flame lengths, flame temperatures, and combustion product concentrations of combusting swirling dual-disk double-concentric jets were studied. The Reynolds number of the annular swirling air jet was varied, while it was fixed at 2500 for the central propane jet. The central fuel jet was acoustically forced by a loudspeaker, which was installed using downstream longitudinal irradiation. The central jet pulsation intensities were measured by a calibrated, one-component hot-wire anemometer. The instantaneous full-length and close-up flame images were captured to identify the characteristic flame modes. Long-exposure flame images were taken to measure the flame lengths. The axial and radial temperature distributions of flames were measured using a homemade, fine-wire R-type thermocouple. The concentrations of combustion products were measured by a gas analyzer. Four characteristic flame modes, blue-base wrinkled flame, yellow-base anchored flame, blue-base anchored flame, and lifted flame, were observed in the domain of central jet pulsation intensity and annular swirling jet Reynolds number. The lifted flame, which was formed at large central jet pulsation intensities, presented characteristics of a premixed flame due to significant mixing induced by violent, turbulent flow motions. It was short and stable, with high combustion efficiency and low toxic emissions, when compared with the unexcited flame and other excited characteristic flame modes, which presented characteristics of diffusion flame.
Phorbasins G–K: new cytotoxic diterpenes from a southern Australian marine sponge, Phorbas sp. (2008)

Fractionation of a cytotoxic extract obtained from a southern Australian marine sponge, Phorbas sp., yielded the known diterpenes phorbasins B-F () together with five new members of the phorbasin family, phorbasins G-K (). Structures were assigned to the new phorbasins based on detailed spectroscopic analysis. A preliminary structure activity relationship (SAR) evaluation based on the co-metabolites phorbasins B-K () revealed aspects of the phorbasin pharmacophore.
Precision and performance of polysilicon micromirrors for hybrid integrated optics (1995)

We have designed and built integrated, movable micromirrors for on-chip alignment in silicon- optical-bench technology. The mirrors are fabricated using surface micromachining with three polysilicon layers. A polysilicon-hinge technology was used to achieve the required vertical dimensions and functionality for alignment in hybrid photonic integrated circuits. The positioning accuracy of the mirrors is measured to be on the order of 0.2 micrometers . This precision is shown theoretically and experimentally to be sufficient for laser-to-fiber coupling. In the experimental verification, we used external actuators to position the micromirror and obtained 45% coupling efficiency from a semiconductor laser (operating at 1.3 micrometers ) to a standard single-mode optical fiber. The stability and robustness of the micromirrors were demonstrated in shock and vibration tests that showed that the micromirrors will withstand normal handling and operation without the need for welding or gluing. This micromirror technology combines the low-cost advantage of passive alignment and the accuracy of active alignment. In addition to optoelectronic packaging, the micromirrors can be expected to find applications in grating-tuned external-cavity lasers, scanning lasers, and interferometers.
A first in man study to evaluate the safety, pharmacokinetics and pharmacodynamics of RP7214, a dihydroorotate dehydrogenase inhibitor in healthy subjects (2022)

Dihydroorotate dehydrogenase (DHODH) is a mitochondrial enzyme that is essential for pyrimidine de novo synthesis. Rapidly growing cancer cells and replicating viruses are dependent on host cell nucleotides, the precursors of which are provided by DHODH. Hence, DHODH becomes an ideal target for pharmacological intervention. RP7214 is a potent and selective inhibitor of human DHODH and has shown antiviral and antileukaemic activity in preclinical studies. This paper describes the phase I study that evaluated the safety and pharmacokinetics of single and multiple ascending doses (SAD and MAD) and the food effect of RP7214 in healthy volunteers (HVs). The study was a randomized, double-blind, placebo-controlled trial of single dose (100, 200 and 400 mg QD), multiple doses (200 and 400 mg BID for 7 days) and a food effect study at a single dose of 200 mg. A total of 18, 12 and 12 HVs were enrolled in the SAD, MAD and food effect parts of the study, respectively. RP7214 was well tolerated at all dose levels. There were 20 treatment-emergent adverse events (TEAEs) reported, out of which most were mild to moderate in severity while three TEAEs were grade ≥3. RP7214 showed accumulation on multiple dosing. Steady-state concentrations were reached within about 3-6 days. The mean plasma half-life at steady-state was 12.8 hours (9.9-15.3). Food did not impact the absorption of RP7214. Inhibition of DHODH, as evidenced by increased dihydroorotate levels, was observed, confirming target engagement. The high systemic exposure with a favourable safety profile shows potential for the development of RP7214 in SARS-CoV-2 and acute myeloid leukaemia (NCT04680429).
Anti-I-A antibody modulation of lymphocyte traffic in hapten-stimulated inbred mice. (1987)

Injection of the hapten azobenzenearsonate (ABA) under mouse ear skin results in increased weight and accumulation of injected radiolabelled syngeneic lymphocytes in the draining auricular lymph node relative to the contralateral node. Intravenous injection of ABA hapten-coupled spleen cells results in a similar accumulation of labelled cells in recipient spleens. The kinetics, antigen-dose effects and enhancement by priming indicate an active host-initiated lymphocyte trapping response. ABA-induced splenic and nodal trapping and increased lymph node weight were prevented by in vivo administration of anti-I-A monoclonal antibody prior to and coincident with antigen injection. Anti-I-A antibody did not significantly alter traffic of labelled T-enriched lymphocytes in non-antigen draining tissues.
Responses are durable for up to 5 years after completion of peginterferon alfa‐2a treatment in hepatitis B e antigen‐positive patients (2018)

Seroconversion rates are durable for up to 5 years after completion of peginterferon alfa-2a therapy and, consistent with NEPTUNE, the results suggest that the licensed regimen (180 μg × 48 weeks) is more efficacious for HBeAg-positive patients than a lower dose and/or shorter treatment duration.
Acute regulation of tight junction ion selectivity in human airway epithelia (2009)

Electrolyte transport through and between airway epithelial cells controls the quantity and composition of the overlying liquid. Many studies have shown acute regulation of transcellular ion transport in airway epithelia. However, whether ion transport through tight junctions can also be acutely regulated is poorly understood both in airway and other epithelia. To investigate the paracellular pathway, we used primary cultures of differentiated human airway epithelia and assessed expression of claudins, the primary determinants of paracellular permeability, and measured transepithelial electrical properties, ion fluxes, and La(3+) movement. Like many other tissues, airway epithelia expressed multiple claudins. Moreover, different cell types in the epithelium expressed the same pattern of claudins. To evaluate tight junction regulation, we examined the response to histamine, an acute regulator of airway function. Histamine stimulated a rapid and transient increase in the paracellular Na(+) conductance, with a smaller increase in Cl(-) conductance. The increase was mediated by histamine H(1) receptors and depended on an increase in intracellular Ca(2+) concentration. These results suggest that ion flow through the paracellular pathway can be acutely regulated. Such regulation could facilitate coupling of the passive flow of counter ions to active transcellular transport, thereby controlling net transepithelial salt and water transport.
Guest Editorial: Switching and Routing for Scalable and Energy-Efficient Networking (2014)

The articles i nthis special issue focus on switching and routing applications for scalable and energy efficient networking.
Dynamic molecular recognition in a multifunctional porphyrin and a ubiquinone analog (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDynamic molecular recognition in a multifunctional porphyrin and a ubiquinone analogTakashi Hayashi, Tomohito Asai, Hirohisa Hokazono, and Hisanobu OgoshiCite this: J. Am. Chem. Soc. 1993, 115, 25, 12210–12211Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://doi.org/10.1021/ja00078a088RIGHTS & PERMISSIONSArticle Views241Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (931 KB) Get e-AlertsSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Turbulent coagulation of aerosols in a stirred tank. (1977)

Turbulent coagulation of aerosol particles was studied experimentally by observing the time-dependent changes in particle number concentration and size distribution of aerosol for various intensities of stirring in a stirred tank, using the ultramicroscopic size analysis. From the observed data on the decrease in particle number concentration of aerosol, the rate constants of turbulent coagulation were evaluated and compared with some of the most representative theories, and were found in good agreement with Saffman and Turner''s theory. Further, the changes in particle size distribution observed were confirmed by those obtained by numerically solving the equation of coagulation for polydisperse aerosol, the so-called population balance equation.
Agrochemicals against Malaria, Sleeping Sickness, Leishmaniasis and Chagas Disease (2012)

In tropical regions, protozoan parasites can cause severe diseases with malaria, leishmaniasis, sleeping sickness, and Chagas disease standing in the forefront. Many of the drugs currently being used to treat these diseases have been developed more than 50 years ago and can cause severe adverse effects. Above all, resistance to existing drugs is widespread and has become a serious problem threatening the success of control measures. In order to identify new antiprotozoal agents, more than 600 commercial agrochemicals have been tested on the pathogens causing the above mentioned diseases. For all of the pathogens, compounds were identified with similar or even higher activities than the currently used drugs in applied in vitro assays. Furthermore, in vivo activity was observed for the fungicide/oomyceticide azoxystrobin, and the insecticide hydramethylnon in the Plasmodium berghei mouse model, and for the oomyceticide zoxamide in the Trypanosoma brucei rhodesiense STIB900 mouse model, respectively.