gebhart/patrepeval huggingface dataset:
Double-Phase-Shifter Based Hybrid Beamforming for mmWave DFRC in the Presence of Extended Target and Clutters (2022)

In millimeter-wave (mmWave) dual-function radar-communication (DFRC) systems, hybrid beamforming (HBF) is recognized as a promising technique utilizing a limited number of radio frequency chains. In this work, in the presence of extended target and clutters, a HBF design based on the subarray connection architecture is proposed for a multiple-input multiple-output (MIMO) DFRC system. In this HBF, the double-phase-shifter (DPS) structure is embedded to further increase the design flexibility. We derive the communication spectral efficiency (SE) and radar signal-to-interference-plus-noise-ratio (SINR) with respect to the transmit HBF and radar receiver, and formulate the HBF design problem as the SE maximization subjecting to the radar SINR and power constraints. To solve the formulated nonconvex problem, the joinT Hybrid bEamforming and Radar rEceiver OptimizatioN (THEREON) is proposed, in which the radar receiver is optimized via the generalized eigenvalue decomposition, and the transmit HBF is updated with low complexity in a parallel manner using the consensus alternating direction method of multipliers (consensus-ADMM). Furthermore, we extend the proposed method to the multi-user multiple-input single-output (MU-MISO) scenario. Numerical simulations demonstrate the efficacy of the proposed algorithm and show that the solution provides a good trade-off between number of phase shifters and performance gain of the DPS HBF.
Chemical Modification of Poly(styrene-co-acrylonitrile) in a Melt (2000)

Calandering, injection moulding and extrusion are the common processes for thermoplastic polymers. The modification of industrial polymers by reactive extrusion is an excellent way to produce thermoplastic polymers with special capabilities. Heterocyclic structures can also be introduced using this method. They can then be used as a basis for various further modifications and treatments.
Poroelectroelastic theory of water sorption and swelling in polymer electrolyte membranes (2011)

This paper presents a novel poroelectroelastic model of equilibrium water sorption and swelling in polymer electrolyte membranes. These phenomena determine transport properties, electrochemical performance, durability and lifetime of the membrane in a polymer electrolyte fuel cell. Based on a consistent treatment of thermodynamic equilibrium conditions, involving capillary, osmotic and elastic effects, we establish the equation of state of water in a single membrane pore. It relates the charge density at the pore walls to a microscopic swelling parameter. Extended to the water sorption equilibrium in a pore ensemble, the model reconciles microscopic swelling in a single pore with macroscopic swelling of the membrane. Theoretical relations are developed that rationalize the impact of external conditions, statistical distribution of anionic head groups and elastic properties of the polymer on water sorption and swelling. The model resolves Schröder's paradox and other unexplained phenomena related to water sorption equilibria, pressure distribution, and transport properties in PEM.
Alternative therapies for the management of inhibitors (2016)

The development of inhibitors to factor VIII (FVIII) or factor IX (FIX) remains a major treatment complication encountered in the treatment of haemophilia. Not all patients with even the same severity and genotype develop inhibitors suggesting an underlying mechanism of tolerance against FVIII- or FIX-related immunity. One mechanism may be central tolerance observed in patients in whom the FVIII mutation enables some production of the protein. The other is a peripheral tolerance mechanism which may be evident in patients with null mutation. Recently, recombinant porcine FVIII (rpFVIII, Obixur, OBI-1, BAX801) has been developed for the haemostatic treatment of both congenital haemophilia with inhibitor (CHAWI) and acquired haemophilia A (AHA). In 28 subjects with AHA with life-/limb-threatening bleeding, rpFVIII reduced or stopped bleeding in all patients within 24 h. The cross-reactivity of anti-human FVIII antibodies to rpFVIII remains around 30-50%. Recently, new therapeutics based on the quite novel concepts have been developed and clinical studies are ongoing. These are humanized asymmetric antibody mimicking FVIIIa function by maintaining a suitable interaction between FIXa and FX (Emicizumab, ACE910), and small interfering RNAs (siRNA, ALN-AT3) suppress liver production of AT through post-transcriptional gene silencing and a humanized anti-TFPI monoclonal antibody (Concizumab). Their main advantages are longer half-life, subcutaneous applicability and efficacy irrespective of the presence of inhibitors which will make it easier to initiate more effective treatment especially early childhood.
Solder self-assembled micro axial flow fan driven by a scratch drive actuator rotary motor (2002)

This work presents the first micro-sized axial flow fan driven by a scratch drive actuator rotary motor. The eight fan blades are mass assembled using the surface tension of molten 4 mil diameter 63 Sn/37 Pb manufactured solder spheres. A sample size of 27 blade angles was measured with a mean assembly angle of 107.24/spl deg/. The actual mean of the manufactured solder sphere diameters was measured at 4.89 mils, yielding a, model predicted, mean blade assembly angle of 107.71/spl deg/. At resonance, the SDA motor can be driven at 50 RPM forward with a 2 kHz AC voltage of 30 V/sub 0.P/, and at 100 RPM reverse with a 3 kHz signal. For non-resonant frequencies, the SDA motor can be driven in a forward direction with linear speed control up to 180 RPM using driving signals from 75-150 V/sub 0.P/. Fluid movement by the fan was also experimentally demonstrated.
Significance of self-reported sleep quality (SQ) in chronic kidney disease (CKD): the Renal Research Institute (RRI)-CKD study (2010)

Self-reported "poor" SQ was common in a CKD cohort (Stages 3 - 5) and was not only associated with lower quality of life scores and several modifiable symptoms, but also with higher risk of pre-ESRD mortality. Greater attention to this clinical problem is highly recommended in this high-risk population.
Electron and Proton Radiation Effects on Band Structure and Carrier Dynamics in MBE and MOCVD Grown III-V Test Structures (2018)

As part of a continuing study on radiation effects in photovoltaic materials, we exposed a series of AlGaAs/GaAs double heterostructures grown by molecular beam epitaxy and metalorganic chemical vapor deposition to electron and proton radiation. The active regions of the test articles were doped either unintentionally, <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">p</i> -type or <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</i> -type. Steady state and time resolved photoluminescence spectroscopy were used to characterize changes to the band structure and carrier dynamics. The effect of electron radiation on low temperature photoluminescence spectra and on room temperature carrier lifetime varied with dopant type and density. Steady-state photoluminescence reveals distinct effects from electron and proton exposures.
Reversible hyperphagia and obesity in rats with gastric bypass by central MC3/4R blockade (2014)

RYGB rats do not settle at a lower level of body weight because they cannot eat more food as they can easily double food intake by increasing meal frequency. The reversible obesity suggests that RYGB rats actively defend the lower body weight. However, because both RYGB and sham-operated rats responded to SHU9119, central melanocortin signaling is not the critical mechanism in RYGB rats responsible for this defense.
Practical verifications for coverage and capacity predictions and simulations in real-world cellular UMTS networks (2012)

This paper presents verifications for UMTS coverage and capacity in a live network using planning and performance tools applied to a real-world operational UMTS network. Case study results are presented and followed by comparisons between coverage predictions, capacity simulations, field measurements and system statistics. Tuned propagation models based on area clutter, population profiles, digital height maps and base station (BS) engineering elements are taken into account to match the outputs of the planning tool to the practical drive-test and UMTS Terrestrial Radio Access Network (UTRAN) system Key Performance Indicators (KPIs) measurements. This work outcome addresses the importance of using planning tools for dimensioning coverage and capacity aspects in UMTS networks and draw some attention to network future optimization, load balancing and congestions relief in advance before system traffic statistics are being generated or afterwards as supplementary grounds for network optimization and maintenance that support statistics.
Embedding adaptive stimulation algorithms for a new implantable deep-brain stimulation research tool (2018)

While deep brain stimulation (DBS) has been used for decades to treat neurological movement disorders, the reliance on tonic stimulation may be limiting the therapy from reaching its maximum potential. Ongoing research into adaptive stimulation that adjusts therapy in response to sensed biomarkers of symptom or patient state has started to show potential benefits of closed-loop DBS therapies. However, much of the previous work on the adaptive DBS relied on systems or algorithms for acute implementation, rather than “embedded” algorithms for out of the clinic use. In this paper, we discuss and demonstrate the capabilities for a next generation investigational human-use implantable research platform for adaptive DBS studies that has expanded embedded algorithm capabilities to enable new adaptive DBS studies in the less controlled environments of a patient's daily life.
Antioxidant-Based Medicinal Properties of Stingless Bee Products: Recent Progress and Future Directions (2020)

Stingless bees are a type of honey producers that commonly live in tropical countries. Their use for honey is being abandoned due to its limited production. However, the recent improvements in stingless bee honey production, particularly in South East Asia, have brought stingless bee products back into the picture. Although there are many stingless bee species that produce a wide spread of products, known since old eras in traditional medicine, the modern medical community is still missing more investigational studies on stingless bee products. Whereas comprehensive studies in the current era attest to the biological and medicinal properties of honeybee (<i>Apis mellifera</i>) products, the properties of stingless bee products are less known. This review highlights for the first time the medicinal benefits of stingless bee products (honey, propolis, pollen and cerumen), recent investigations and promising future directions. This review emphasizes the potential antioxidant properties of these products that in turn play a vital role in preventing and treating diseases associated with oxidative stress, microbial infections and inflammatory disorders. Summarizing all these data and insights in one manuscript may increase the commercial value of stingless bee products as a food ingredient. This review will also highlight the utility of stingless bee products in the context of medicinal and therapeutic properties, some of which are yet to be discovered.
Abstract 3883: Miniaturizing the GloSensor™ cAMP assay for MC4R screening using the Echo® acoustic liquid handler (2012)

Abstract As biological assays used for HTS and uHTS are miniaturized, it is critical to maintain assay sensitivity while minimizing reagent volumes and maximizing throughput. The GloSensor™ cAMP Assay provides an extremely sensitive and easy to use, real-time luminescent assay format for the interrogation of over expressed or endogenous GPCRs that signal via changes in the intracellular concentration of cAMP. Tipless, touchless transfers with the Echo® liquid handler eliminate the need for costly disposable tips and greatly simplify assay development efforts. Precise and accurate drop placement eliminates cross-contamination. In this work, we demonstrate optimization of the GloSensor cAMP Assay in low-volume format using a stably transfected HEK293 cell line model expressing the melanocortin 4 receptor (MC4R) and a cAMP-sensing variant of firefly luciferase. We show that the Echo liquid handler is able to titrate small molecule and peptide agonists and antagonists, as well as transfer the GloSensor cAMP Reagent, providing robust assay results that are achieved with significantly reduced volumes of cells and compound. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3883. doi:1538-7445.AM2012-3883
A Security Oriented Architectural Approach for Mobile Agent Systems (2000)

Security is a critical parameter for the expansion and wide usage of agent technology. A threat model is constructed and subsequently the basic techniques to deal effectively with these threats are analyzed. Then this paper presents a dynamic, extensible, configurable and interoperable security architecture for mobile agent systems. It is explained how this architecture can be used to tackle a big par of security threats. All the components of the security architecture are analyzed while we also argue for the benefits they offer.
Subwavelength far-field ultrasound drug-delivery (2016)

The theoretical diffraction-limit of resolution for ultrasound imaging has recently been bypassed in-vitro and in-vivo. However, in the context of ultrasound therapy, the precision of therapeutic beams remains bound to the half-wavelength limit. By combining acoustic vaporization of composite droplets and rapid ultrasound monitoring, we demonstrate that the ultrasound drug-delivery can be restricted to a subwavelength zone. Moreover, two release zones closer than the wavelength/4 can be distinguished both optically and through ultrafast ultrasound localization microscopy. This proof-of-concept let us envision the possibility to treat specific tissues more precisely without compromising on the penetration depth of the ultrasound wave.
mTOR Kinase Domain Phosphorylation Promotes mTORC1 Signaling, Cell Growth, and Cell Cycle Progression (2011)

The mammalian target of rapamycin complex 1 (mTORC1) functions as an environmental sensor to promote critical cellular processes such as protein synthesis, cell growth, and cell proliferation in response to growth factors and nutrients. While diverse stimuli regulate mTORC1 signaling, the direct molecular mechanisms by which mTORC1 senses and responds to these signals remain poorly defined. Here we investigated the role of mTOR phosphorylation in mTORC1 function. By employing mass spectrometry and phospho-specific antibodies, we demonstrated novel phosphorylation on S2159 and T2164 within the mTOR kinase domain. Mutational analysis of these phosphorylation sites indicates that dual S2159/T2164 phosphorylation cooperatively promotes mTORC1 signaling to S6K1 and 4EBP1. Mechanistically, S2159/T2164 phosphorylation modulates the mTOR-raptor and raptor-PRAS40 interactions and augments mTORC1-associated mTOR S2481 autophosphorylation. Moreover, mTOR S2159/T2164 phosphorylation promotes cell growth and cell cycle progression. We propose a model whereby mTOR kinase domain phosphorylation modulates the interaction of mTOR with regulatory partner proteins and augments intrinsic mTORC1 kinase activity to promote biochemical signaling, cell growth, and cell cycle progression.
The Relevance of a Novel Quantitative Assay to Detect up to 40 Major Streptococcus pneumoniae Serotypes Directly in Clinical Nasopharyngeal and Blood Specimens (2016)

For epidemiological and surveillance purposes, it is relevant to monitor the distribution and dynamics of Streptococcus pneumoniae serotypes. Conventional serotyping methods do not provide rapid or quantitative information on serotype loads. Quantitative serotyping may enable prediction of the invasiveness of a specific serotype compared to other serotypes carried. Here, we describe a novel, rapid multiplex real-time PCR assay for identification and quantification of the 40 most prevalent pneumococcal serotypes and the assay impacts in pneumonia specimens from emerging and developing countries. Eleven multiplex PCR to detect 40 serotypes or serogroups were optimized. Quantification was enabled by reference to standard dilutions of known bacterial load. Performance of the assay was evaluated to specifically type and quantify S. pneumoniae in nasopharyngeal and blood samples from adult and pediatric patients hospitalized with pneumonia (n = 664) from five different countries. Serogroup 6 was widely represented in nasopharyngeal specimens from all five cohorts. The most frequent serotypes in the French, South African, and Brazilian cohorts were 1 and 7A/F, 3 and 19F, and 14, respectively. When both samples were available, the serotype in blood was always present as carriage with other serotypes in the nasopharynx. Moreover, the ability of a serotype to invade the bloodstream may be linked to its nasopharyngeal load. The mean nasopharyngeal concentration of the serotypes that moved to the blood was 3 log-fold higher than the ones only found in the nasopharynx. This novel, rapid, quantitative assay may potentially predict some of the S. pneumoniae serotypes invasiveness and assessment of pneumococcal serotype distribution.
Effects of stimulus duration on gustatory evoked potentials (2016)

The objective of the present study was to investigate the effect of tastant stimulus duration on the brain response. The brain response was measured by electroencephalography (EEG) which measures neural processes with high temporal resolution and may therefore complement sensory panel assessments. <br/><br/>19 normal-tasting subjects (10 females, mean age ± sd: 27 ± 3) were stimulated with aqueous 0.5g/L sucralose in between continuous periods of non-chlorinated tap water to avoid somatosensory onsets. The sucralose stimulus duration was either short (~0.6s) or long (~4s) and presented in random sequence with 60 repetitions. The stimuli were delivered to the center of the tongue apex innervated by chorda tympani nerve. Brain response was recorded with 128 electrodes and the gustatory event related potential (GEP) was estimated by coherent averaging of all artefact free epochs. <br/> <br/>Focusing on the FC5 electrode, which is located at the left frontotemporal region relatively close to the primary gustatory cortex in the insula, significant GEPs were obtained after 100ms (t-test) and the first peak occurred at 200ms corresponding to negative deflections at the temporal lobes for both stimuli. The long sucralose stimulation kept the GEP significant for longer and produced a larger peak occurring at ~1.6sec (t-test) while maintaining the characteristic negative temporal deflection as opposed to the short stimulation which produced frontal activity. <br/><br/>Instances of brain response to varying NaCl stimulus durations were demonstrated by Plattig (1991), while this study is the first to include multiple subjects and electrodes. Interestingly, we found that tastant stimulus duration was positively correlated with significant brain response duration at the primary gustatory cortex. Surprisingly, the long sucralose stimulation duration resulted in larger GEP peak amplitude above the gustatory cortex and may indicate higher intensity perception (Kelling and Halpern, 1988).<br/>
DeepCEST: 9.4 T Chemical exchange saturation transfer MRI contrast predicted from 3 T data – a proof of concept study (2019)

The 9.4 T CEST signals acquired at low saturation power can be accurately estimated from CEST imaging at 3 T using a neural network trained with coregistered 3 T and 9.4 T data of healthy subjects. The deepCEST approach generalizes to Z-spectra of tumor areas and might indicate whether additional ultrahigh-field (UHF) scans will be beneficial.
Formal Model for Semantic Web Service Composition (2005)

Automated composition of Web services or the process of forming new value added Web services is one of the most promising challenges in the semantic Web service research area. Semantics is one of the key elements for the automated composition of Web services because such a process requires rich machine-understandable descriptions of services that can be shared. Semantics enables Web service to describe their capabilities and processes, nevertheless there is still some work to be done. Indeed Web services described at functional level need a formal context to perform the automated composition of Web services. The suggested model (i.e., Causal link matrix) is a necessary starting point to apply problem-solving techniques such as regression-based search for Web service composition. The model supports a semantic context in order to find a correct, complete, consistent and optimal plan as a solution. In this paper an innovative and formal model for an AI planning-oriented composition is presented.
Crystallographic Transitions in Several Chromium Spinel Systems (1963)

The systems NixFe1−xCr2O4, CuxNi1−xCr2O4, and CuxCo1−xCr2O4 have been prepared and their crystallographic properties studied. From consideration of Jahn-Teller effects, it was shown that A-site Cu2+ is more effective than A-site Fe2+ in stabilizing a tetragonal (c/a&amp;lt;1) distortion at A-site Ni2+. In addition considerably more Cu2+ is required on the A site to distort CoCr2O4 from cubic symmetry to c/a&amp;lt;1 than is required to change the distortion of NiCr2O4 from c/a&amp;gt;1 to c/a&amp;lt;1.
Allogeneic or autologous transplantation as first-line therapy for younger patients with peripheral T-cell lymphoma: Results of the interim analysis of the AATT trial. (2015)

8507 Background: AlloSCT gives encouraging results in pts with relapsed PTCL. We did the AATT (Autologous or Allogeneic Transplantation in T-Cell Lymphoma) study in newly diagnosed PTCL and present results of an interim analysis leading to termination of the trial. Methods: We compared alloSCT with autoSCT in younger pts with PTCL. Pts were randomized after enrolment. Treatment was four courses of CHOEP-14. Pts achieving CR/ PR/ SD proceeded to DHAP and stem cell collection in pts randomized to autoSCT or without suitable (HLA 10/10) donor. BEAM high-dose therapy and autoSCT or myeloablative conditioning and alloSCT followed within 4-6 weeks. Results: 58/104 pts were eligible: median age was 50 years, 64% of pts were male. 11/30 pts randomized to autoSCT did not proceed to transplantation because of progressive disease / no response (n=8), infection (n=1) or change of histology (n=2). 13/28 pts (46%) randomized to alloSCT received it. Fifteen pts were not allografted due to progressive disease (n=10) or l...
Time-Resolved Dynamics in N 2 O 4 Probed Using High Harmonic Generation (2008)

The attosecond time-scale electron-recollision process that underlies high harmonic generation has uncovered extremely rapid electronic dynamics in atoms and diatomics. We showed that high harmonic generation can reveal coupled electronic and nuclear dynamics in polyatomic molecules. By exciting large amplitude vibrations in dinitrogen tetraoxide, we showed that tunnel ionization accesses the ground state of the ion at the outer turning point of the vibration but populates the first excited state at the inner turning point. This state-switching mechanism is manifested as bursts of high harmonic light that is emitted mostly at the outer turning point. Theoretical calculations attribute the large modulation to suppressed emission from the first excited state of the ion. More broadly, these results show that high harmonic generation and strong-field ionization in polyatomic molecules undergoing bonding or configurational changes involve the participation of multiple molecular orbitals.