gebhart/patrepeval huggingface dataset:
Respiratory gating of sliding window IMRT (2002)

Breathing motion may limit sites of applicability for intensity modulated radiation therapy (IMRT). Respiratory gating reduces motion by activating the beam during a chosen phase of respiration. We investigated the effect of gating on the dose distribution of sliding window dynamic multileaf collimator (DMLC) fields. A Varian 2100C beam was gated by the Varian real time position management system that tracks moving infrared reflective markers with a wall-mounted camera. A rotating eccentric wheel simulated marker breathing motion. Dose distributions from normal (ungated) and gated DMLC fields were compared using film dosimetry and also by calculating dose distributions from the leaf motion log files. Fields included prostate (15 MV) and H&N (6 MV) treatment fields and special test fields. Kodak V films under polystyrene phantom were exposed separately for gated and ungated operation. Additional ungated fields were filmed as controls. Log files for gated and ungated deliveries were copied to a program written in-house which uses the clinical treatment planning system to calculate the dose distribution delivered by the recorded leaf motion. The films were digitized, optical densities converted to dose, and matched pairs of films were registered. The largest differences (/spl ap/5% or /spl sim/1 mm) occurred in high dose gradient regions and were consistent with uncertainties in aligning pairs of films. Gated vs. ungated dose distributions calculated from the fog files agreed to better than 0.5%. These preliminary results show no deleterious effects of gating on DMLC dose distributions.
Graphene and MoS2: Pushing the Limits of Electronics Through Heterogeneous Integration (2023)

Two-dimensional (2D) materials such as graphene and molybdenum disulfide (MoS<inf>2</inf>) offer unique properties to enhance the performance of Silicon-based microelectronic systems. These include excellent carrier confinement, electrostatic control and mobility thanks to their atomic-layer thickness and negligible interface scattering. This talk will describe several heterogeneous integration technologies that allow the close integration of these materials with state-of-the-art silicon CMOS wafers in applications such as electronic nose systems, RF energy harvesting, and infrared cameras. In addition, the proposed low temperature heterogeneous integration technology is key for several new transistor architectures, such as atom-thick multi-sheet transistors, that can help to push Moore's law even further for CMOS chips. Our preliminary work on these new devices will also be presented.
The operational difficulty of standardizing frequency restoration products (2017)

This paper assesses operational impacts of the Continental European power plant portfolio on a harmonization of load-frequency control. The technical basics are presented together with an 18-area system of Continental Europe implemented in SIMULINK. The results reveal significant differences in frequency restoration among control areas. These differences originate from country-specific power plant portfolios as well as non-standardized control and activation parameters. An evaluation of pro rata and merit order activation demonstrates that frequency restoration can be harmonized to a certain extent but can cause both improvement or deterioration for control areas. Product standardization in the scope of market design and the choice of technical parameters in the scope of system operation are inextricably linked.
A pass transistor design methodology for 256 Mbit DRAM and beyond (2002)

A novel pass transistor design methodology to optimize gate oxide thickness (t/sub ox/), booted wordline voltage (V/sub WL/), substrate bias (V/sub sub/), and processing conditions is presented in this paper. It is found that for a gate length of 0.3 /spl mu/m a t/sub ox/ of about 85 /spl Aring/ (which is much thicker than the /spl sim/65 /spl Aring/ t/sub ox/ for 0.25 /spl mu/m logic technology) to support a V/sub WL/ of 3.75 V, a V/sub sub/ of about -1 V, and As LDD are the optimum technological choices for 256 Mbit DRAM.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Le développement de compétences en conception de systèmes embarqués via l'apprentissage par problèmes et par projets (2008)

Cet article montre comment le développement de compétences en conception de systèmes embarqués peut être réalisé dans le cadre d'une approche pédagogique par problèmes et par projets dans un programme d'ingénierie. Cette mise en oeuvre a été effectuée au sein du programme de baccalauréat en génie informatique de l'Université de Sherbrooke qui s'offre entièrement selon cette approche pédagogique. Les systèmes embarqués constituent le thème d'une session d'étude au complet dans le programme. L'intégration des compétences liées aux systèmes embarqués se fait par le biais d'un projet impliquant le développement d'une application construite autour d'une unité mobile connectée à un serveur d'application via un lien sans fil et une passerelle IP. L'acquisition des compétences de base en systèmes embarqués se fait au travers d'une série de problématiques résolues par l'étudiant tout au long de la même session d'étude.
THE ANTIPROLIFERATIVE ASPECTS OF MORTALIN (REVIEW) (1995)

Cellular mortal and immortal phenotypes as defined by the limited and the infinite capacity of cells to divide are the characteristics of normal and cancerous cells in culture. Numerous strategies that have been employed to understand the mechanism(s) of normal as well as tumor cell growth have revealed that these are genetically controlled, however, the genes and the synchronized regulations remain largely undefined so far. The present report reviews the identification of mortalin, a novel member of murine hsp70 family of proteins, as a gene involved in pathways that determine divisional phenotype of cells in vitro. In the present study, the anti-proliferative activity of mortalin is demonstrated also in human skin fibroblasts (TIG-73PD) by microinjection of anti-mortalin antibody. Furthermore, studies on the mortalin immunofluorescence patterns in SV40-immortalized pre-crisis and post-crisis human cells have revealed that the change in the intracellular distribution of mortalin is linked to the change in the divisional phenotype of cells. Thus, the studies to resolve the molecular basis of association of the cytosolically distributed form of mortalin with cellular mortal phenotype would be important in understanding of the mechanism(s) that determine replicative potential of cells in culture.
Design optimizations for microprocessors at low temperature (2004)

We investigate trade-offs in microprocessor frequency and system power achievable for low temperature operation in scaled high leakage technologies by combining refrigeration with supply voltage selection, body bias, transistor sizing and shorter channel length. Reducing channel length provides better frequency and power improvement than forward body bias. When, the leakage power is more than 30 of chip power, combining refrigeration with enhancing technology by shorter channel length provides the best trade-off for power and frequency.
Thermodynamically controlled supramolecular polymerization of cytochrome b562 (2008)

A hemoprotein-based supramolecular polymer that has a covalently linked heme moiety on the protein surface has been constructed based on interprotein heme-heme pocket interactions of the chemically modified apocytochrome b(562) (1-H63C). The thermodynamic properties of the polymer have been investigated by means of size exclusion chromatography, UV-vis spectroscopy, and circular dichroism spectroscopy. The results indicate that, as with other synthetic systems reported so far, the 1-H63C hemoprotein assembly is thermodynamically controlled in aqueous solution: the degree of polymerization is dependent on the 1-H63C concentration and is modulated by the addition of the end-capping units, native heme, and/or apocytochrome b(562) mutant (apoH63C). These properties suggest a potential use for the hemoprotein self-assembly in preparation of stimuli-responsive functional nanobiomaterials.
Domino syntheses of five-, six- and seven-membered O-, N- and S-heterocycles from α-, β- and γ-substituted carboxylic esters (1996)

By a one-pot procedure, tetronic acids, tetronates, coumarins, benzoxepinones and their N- and S-analogues are readily accessible from keteneylidene(triphenyl)phosphorane 2 and carboxylic esters bearing OH, NHR or SH groups in an α-, β- or γ-position by an addition/Wittig olefination/(Claisen rearrangement) sequence. This cascade can be controlled by temperature variation. Extension of this procedure by a further addition step yielding annulated bisheterocycles such as the furoquinolone 28 is possible in some cases.
Phase II, 3-arm study of CCI-779 in combination with letrozole in postmenopausal women with locally advanced or metastatic breast cancer: preliminary results (2004)

544 Background: CCI-779, a novel mTOR kinase inhibitor, is well tolerated and has shown antitumor activity in heavily pretreated patients (pts) with metastatic breast cancer (MBC). The combination of CCI-779 (CCI) and antiestrogens has an additive effect in preclinical models of breast cancer. Thus, the objective of this clinical trial is to evaluate preliminary activity of CCI in combination with letrozole. Methods: Randomization is in a 1:1:1 ratio (∼30 evaluable pts/arm), letrozole alone: letrozole with CCI daily (CCI daily arm): letrozole with CCI daily for 5 days every 2 weeks (CCI intermittent arm). All pts receive 2.5 mg letrozole daily. Results: Fifty-five pts have been enrolled. Initially, 6 pts were enrolled on each of the high-dose (HD) schedules, 25 mg CCI daily and 75 mg CCI intermittent; 3 pts in each arm had toxicity that resulted in dose delay/reduction or discontinuation. Thus, the protocol was amended and doses were reduced to low-dose (LD) schedules, 10 mg CCI daily and 30 mg CCI intermittent. As of 01 Dec 2003, 12 and 23 pts were enrolled on the HD and LD schedules, respectively. The median age was 60 yrs (range, 42–81). Safety data are available for 12 pts treated with the HD schedules (25 mg, 6 pts; 75 mg, 6 pts), 11 pts treated with the LD schedules (10 mg, 4 pts; 30 mg, 7 pts), and 12 pts treated with letrozole alone. The most frequently occurring grade 3–4 CCI-related toxicity was stomatitis for the HD schedules (2/6 pts, 2/6 pts) and diarrhea for the LD schedules (0 pts, 1/7 pts). No grade 3–4 toxicities were reported for pts treated with letrozole alone. Of 55 pts, 7 have been on study for 40+ wks. Preliminary tumor responses (RECIST) are available for 19 evaluable pts. CCI pts (n=13) had 1 complete response (HD schedule), 3 partial responses (HD schedules), 9 stable disease (6 pts on HD schedules, 3 on LD schedules; SD ≥ 24 wks for 4 pts on HD schedules). Letrozole-alone pts (n=6) had 2 PR and 4 SD (SD ≥ 24 wks for 1 pt). Conclusions: The combination of letrozole with 10 mg CCI daily or 30 mg CCI intermittent showed favorable results for tolerability. Accrual is continuing. A phase 3 study will be performed to confirm efficacy. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Wyeth Research Wyeth Pharmaceuticals Wyeth Pharmaceuticals Wyeth
MUTE (2018)

Active Noise Cancellation (ANC) is a classical area where noise in the environment is canceled by producing anti-noise signals near the human ears (e.g., in Bose's noise cancellation headphones). This paper brings IoT to active noise cancellation by combining wireless communication with acoustics. The core idea is to place an IoT device in the environment that listens to ambient sounds and forwards the sound over its wireless radio. Since wireless signals travel much faster than sound, our ear-device receives the sound in advance of its actual arrival. This serves as a glimpse into the future, that we call lookahead, and proves crucial for real-time noise cancellation, especially for unpredictable, wide-band sounds like music and speech. Using custom IoT hardware, as well as lookahead-aware cancellation algorithms, we demonstrate MUTE, a fully functional noise cancellation prototype that outperforms Bose's latest ANC headphone. Importantly, our design does not need to block the ear - the ear canal remains open, making it comfortable (and healthier) for continuous use.
Fast Light in Optical Fiber for Trap-Door Data Buffering (2009)

Constraints encountered in data-buffering via slow light are circumvented by using a trap-door technique based on fast light. We will describe the model and our experimental efforts to realize this buffer using Brillouin gain in optical fiber. Article not Available.
Phylogenetic Studies of the Bullous Pemphigoid Antigen-1 Using Human Monoclonal-antibodies (1995)

Bullous pemphigoid is an autoimmune skin disorder with production of autoantibodies against bullous pemphigoid antigen 1 (BPAg1) and bullous pemphigoid antigen 2 (BPAg2) which are constitutively expressed in hemdesmosomes. Phylogenetic study of the reactivity of 3 human monoclonal antibodies (HuMabs) specific for BPAg1 was performed using immunohistochemical analysis of skin sections. The serum of the 2 BP patients from which the 3 HuMabs were derived stained the basement membrane zone on skin cryostat section of all species tested including fishes, amphibians, reptiles, birds and mammals. However, of the 3 HuMabs BP1, BP2 and BP3, only BP3 reacted with the skin of reptiles, birds and mammals while Bp1 and Bp2 exclusively bound to mammalian skin. These data provide evidence for the existence of multiple epitopes on BPAg1 able to bind autoantibodies.
A fluorogenic screening platform enables directed evolution of an alkyne biosynthetic tool (2016)

Directed evolution was used to improve the activity of JamB, a membrane-bound bifunctional desaturase/acetylenase. To quickly assess the protein engineering outcomes, we developed a new platform for quantifying extracellular alkyne-tagged metabolites through a fluorogenic click reaction. Random mutagenesis yielded the best JamB variant with ∼20-fold increased activity in E. coli.
튜터링 프로그램에 참여한 D대학 대학생들의 자기조절 학습능력 수준에 관한 조사 (2011)

본 연구의 목적은 튜터링 프로그램에 참여한 D대학 학생들의 일반적 특성과 연령에 따른 자기조절 학습능
력의 차이와 튜터와 튜티의 자기조절 학습능력의 차이를 인지조절과 동기조절 및 행동조절로 분류, 조사하여 효율적
인 튜터링 프로그램 운영에 필요한 기초자료를 확보하기 위한 것이다.
2010년 4월 26일부터 6주간 실시된 튜터링 프로그램에 참여한 15개 학과 대학생 200명을 대상으로 자기조절 학습능
력에 관한 설문지를 배포하여 자기기입식 응답법으로 응답한 183명의 자료를 조사하였다. 연구결과 참여자 중 20세
이상의 대학생들은 자기조절학습능력 중 조직화, 메타인지전략의 사용, 계획, 자아효능감, 학업시간관리 능력이 유의
하게 높았다(p<0.05). 또한 튜터는 튜티에 비하여 인지전략의 사용, 시연, 조직화, 메타인지전략의 사용, 계획, 점검,
숙달목적지향성, 자아효능감, 성취가치, 행동통제와 도움을 구하기 능력이 높았다(p<0.05). 결론적으로 튜터링 프로그
램에 참여한 학생들이 1~2년의 학습과정을 통해 전반적인 자기조절학습능력이 높게 나타났음을 확인할 수 있다.
따라서 전문대학에서는 상대적으로 자기조절 학습능력이 부족한 신입생 및 복학생들을 대상으로 상대적인 자기조절
학습능력이 우수한 튜터를 양성하여 튜터링 프로그램과 같은 양질의 학생지원 프로그램을 지원할 필요가 있으며, 향
후 성적이 우수한 선배가 후배들을 지도할 수 있는 학습 환경을 제공하고, 다양한 프로그램을 연구, 개발한다면 튜터
링 프로그램이 점차 차별화되고 효율적인 자기 조절 학습능력향상을 도모할 수 있을 것으로 사료된다.
CrowdTiles (2012)

Time plays a central role in many web search information needs relating to recent events. For recency queries where fresh information is most desirable, there is likely to be a great deal of highly-relevant information created very recently by crowds of people across the world, particularly on platforms such as Wikipedia and Twitter. With so many users, mainstream events are often very quickly reflected in these sources. The English Wikipedia encyclopedia consists of a vast collection of user-edited articles covering a range of topics. During events, users collaboratively create and edit existing articles in near real-time. Simultaneously, users on Twitter disseminate and discuss event details, with a small number of users becoming influential for the topic.
Nonlinear optical properties of LaCa_4O(BO_3)_3 (2001)

We have grown LaCa(4)O (BO(3))(3) (LaCOB), an isostructural member of GdCa(4)O(BO(3))(3) (GdCOB) family and characterized its nonlinear optical properties. At 1064nm, d(eff) of 0.52+/-0.05 pm /V and an angular sensitivity of 1224+/-184(cm rad)(-1) for type I frequency doubling in LaCOB were determined relative to those of KTiOPO(4) , beta-BaB(2)O(4) , KD(2)PO(4) , LiB(3)O(5) , YCa(4)O(BO(3))(3) (YCOB), and GdCOB. The d(alphabetabeta) and d(gammabetabeta) coefficients of the nonlinear optical tensor for LaCOB, GdCOB, and YCOB were determined to be equivalent within the experimental uncertainty and have values of ?0.26+/-0.04?pm/V and ?1.69+/-0.17?pm /V , respectively. From phase-matching angle measurements at 1064 and 1047nm, we predict that LaCOB is noncritically phase matched at 1042+/-1.5 nm .
Assessment of Seasonal Stochastic Local Models for Glucose Prediction without Meal Size Information under Free-Living Conditions (2022)

Accurate blood glucose (BG) forecasting is key in diabetes management, as it allows preventive actions to mitigate harmful hypoglycemic/hyperglycemic episodes. Considering the encouraging results obtained by seasonal stochastic models in proof-of-concept studies, this work assesses the methodology in two datasets (open-loop and closed-loop) recorded in free-living conditions. First, similar postprandial glycemic profiles are grouped together with fuzzy C-means clustering. Then, a seasonal stochastic model is identified for each cluster. Finally, real-time BG forecasting is performed by weighting each model’s prediction. The proposed methodology (named C-SARIMA) is compared to other linear and nonlinear black-box methods: autoregressive integrated moving average (ARIMA), its variant with input (ARIMAX), a feed-forward neural network (NN), and its modified version (NN-X) fed by BG, insulin, and carbohydrates (timing and dosing) information for several prediction horizons (PHs). In the open-loop dataset, C-SARIMA grants a median root-mean-squared error (RMSE) of 20.13 mg/dL (PH = 30) and 27.23 mg/dL (PH = 45), not significantly different from ARIMA and NN. Over a longer PH, C-SARIMA achieves an RMSE = 31.96 mg/dL (PH = 60) and RMSE = 33.91 mg/dL (PH = 75), significantly outperforming the ARIMA and NN, without significant differences from the ARIMAX for PH ≥ 45 and the NN-X for PH ≥ 60. Similar results hold on the closed-loop dataset: for PH = 30 and 45 min, the C-SARIMA achieves an RMSE = 21.63 mg/dL and RMSE = 29.67 mg/dL, not significantly different from the ARIMA and NN. On longer PH, the C-SARIMA outperforms the ARIMA for PH > 45 and the NN for PH > 60 without significant differences from the ARIMAX for PH ≥ 45. Although using less input information, the C-SARIMA achieves similar performance to other prediction methods such as the ARIMAX and NN-X and outperforming the CGM-only approaches on PH > 45min.
Influence of visual technology on the evolution of language environments (1989)

The increasing influence of visual technology on language environments that has resulted from the increasing availability of workstations is discussed. An evolution that began with the relatively straightforward translation of textual techniques into corresponding visual techniques and has progressed to uses of visual techniques that have no natural parallel using purely textural techniques is traced. Visual user interfaces, visual editing, and visual languages are surveyed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
ChemInform Abstract: Three‐Component Catalytic Asymmetric Synthesis of Aliphatic Amines. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Ruthenium‐Catalyzed Reductive Methylation of Imines Using Carbon Dioxide and Molecular Hydrogen (2014)

The use of the well-defined [Ru(triphos)(tmm)] catalyst, CO2 as C1 source, and H2 as reducing agent enabled the reductive methylation of isolated imines, as well as the direct coupling of amines with aldehydes and the subsequent reductive methylation of the in situ formed imines. The method, which afforded the corresponding N-methyl amines in very good to excellent yields, was also used for the preparation of the antifungal agent butenafine in one step with no apparent waste, thus increasing the atom efficiency of its synthesis.
Microfabrication of surface acoustic wave devices with AlN thin film deposited on half‐inch quartz wafer (2022)

Abstract In this paper, we have fabricated surface acoustic wave (SAW) devices with six sets of interdigital transducers (IDTs) on half‐inch wafers of quartz with deposited thin films of aluminum nitride (AlN). Firstly, AlN thin films have been deposited by reactive sputtering in Ar‐N 2 gas mixture at 400°C with the high‐power impulse magnetron sputtering (HiPIMS) system which was developed for microfabrication process in the localized clean environment with half‐inch wafer (Minimal Fab). After that, IDTs of Al thin films have been prepared on the AlN thin films. The X‐ray diffraction (XRD) pattern of the AlN thin films shows that the AlN films have c ‐axis (002) orientation. Furthermore, the frequency responses have been measured with four paired IDTs of the SAW devices, which were selected from six sets of IDTs as an input electrode and an output electrode. These results show device properties responding to the design of the IDTs and also suggest the potential of the fabricated SAW devices as the four‐paralleled frequency filter and/or sensing system.
Phylogenomic analyses of the genusDrosophilareveals genomic signals of climate adaptation (2021)

Many Drosophila species differ widely in their distributions and climate niches, making them excellent subjects for evolutionary genomic studies. Here, we have developed a database of high-quality assemblies for 46 Drosophila species and one closely related Zaprionus. Fifteen of the genomes were newly sequenced, and 20 were improved with additional sequencing. New or improved annotations were generated for all 47 species, assisted by new transcriptomes for 19. Phylogenomic analyses of these data resolved several previously ambiguous relationships, especially in the melanogaster species group. However, it also revealed significant phylogenetic incongruence among genes, mainly in the form of incomplete lineage sorting in the subgenus Sophophora but also including asymmetric introgression in the subgenus Drosophila. Using the phylogeny as a framework and taking into account these incongruences, we then screened the data for genome-wide signals of adaptation to different climatic niches. First, phylostratigraphy revealed relatively high rates of recent novel gene gain in three temperate pseudoobscura and five desert-adapted cactophilic mulleri subgroup species. Second, we found differing ratios of nonsynonymous to synonymous substitutions in several hundred orthologues between climate generalists and specialists, with trends for significantly higher ratios for those in tropical and lower ratios for those in temperate-continental specialists respectively than those in the climate generalists. Finally, resequencing natural populations of 13 species revealed tropics-restricted species generally had smaller population sizes, lower genome diversity and more deleterious mutations than the more widespread species. We conclude that adaptation to different climates in the genus Drosophila has been associated with large-scale and multifaceted genomic changes.
Social Thought and Research, Volume 22, Number 1amp;2 (1999): Book Review (1999)

Review of Carl Boggs' "The Socialist Tradition: From Crisis to Decline" and Kim Moody's "Workers in a Lean World: Unions in the International Economy"