gebhart/patrepeval huggingface dataset:
Numerical implementation of homogenized acoustic properties of periodic porous media (2020)

Noise control and damping has become a major issue in aeronautics. A possible way to damp internal noise in exhausters is to design liners made of porous materials: therefore, the development of numerical tools to predict their acoustical and mechanical properties is needed. In order to avoid overweight of the structure, mechanical strength is required. This requirement wipes out the felts as possible solutions, leaving us with semi-open foams. For reproducibility reasons, the suitable material is likely to be a controlled periodic structure, and as high temperature and thermal shocks are involved, only a metallic alloy can be chosen, so the solid skeleton can be considered as rigid as far as acoustics is concerned. Numerous models describing acoustic properties of a wide class of rigid porous materials can be found in literature, but they all depend on a few parameters such as tortuosity and several characteristic lengths, the evaluation of which anyway require a set of experiments. Thus it does not allow to design potential materials ab initio. In order to do so, a numerical approach is necessary in order to predict the acoustical behaviour of those porous objects. First of all, an homogenisation approach is used to define properly the set of partial differential equations of viscothermal acoustics with their boundary conditions in frequency domain. This approach leads to a formulation close to Stokes’ problem with partially periodic boundary conditions and an extra imaginary coefficient. Then, a finite element method is applied in a variant adapted to viscous fluid flow and the specificities presented above. Numerical results are presented for several elementary geometries for which experimental results are known, and comparisons with classical models are made.
Combustion system CFD modeling at GE Aircraft Engines (1995)

This viewgraph presentation discusses key features of current combustion system CFD modeling capabilities at GE Aircraft Engines provided by the CONCERT code; CONCERT development history; modeling applied for designing engine combustion systems; modeling applied to improve fundamental understanding; CONCERT3D results for current production combustors; CONCERT3D model of NASA/GE E3 combustor; HYBRID CONCERT CFD/Monte-Carlo modeling approach; and future modeling directions.
A HQPM-Based Transmitter with Baseband Predistorter for Simultaneous Enhancement of ACPR and PAE (2007)

Tins paper presents the comparison of signal quality and efficiency performance between simulation and experiment for a linear RF transmitter based on a hybrid quadrature polar modulation (HQPM) architecture with digital predistortion scheme. Adjacent channel power ratio (ACPR) with and without applying the baseband predistorter are both shown to demonstrate improvement in transmitter linearity. The simulated and experimental results have validated the key feature of the proposed HQPM transmitter architecture that its superior power-added efficiency (PAE) is less sensitive to the output power level in comparison with other linear transmitter architectures.
Stabilization of Voltage Limiter Circuit for High‐Density DRAMs Using Miller Compensation (1993)

Abstract The feasibility is examined of using the Miller phase‐compensation circuit to ensure the stability of the voltage limiter circuit in high‐density CMOS DRAMs. First, analytical expressions are obtained for the condition of stabilization to support the comprehensive circuit design and it is shown that both load capacity and load current affect the stability significantly. Second, by using the analytical expressions, parameters for the voltage limiter and the phase compensation circuit are calculated. By computer simulation and experiment voltage variations within the chip are evaluated when the internal circuit operates and external power supply voltage is changed. Results show that the voltage variation caused by the operation of the internal circuit is within 10 percent, resulting in no problem in practice. The voltage variation caused by the change in the external power supply voltage is 3 percent in the case of low‐frequency noise ( t r , t f = 1μs) and is as large as 20 percent in the case of high‐frequency noise ( t r , t f = 10 ns) and attention must be paid to the latter case in the circuit design.
Evaluation of Different Methods of Optical Impression Making on the Marginal Gap of Onlays Created with CEREC 3D (2010)

The marginal gap of CEREC 3D onlay restorations was not different when the optical impression was taken intraorally vs extraorally using a stone cast that does not require powdering. The lingual and occlusal surfaces showed the lowest gaps.
Supplementary Table 1 from HER2-Mediated Internalization of Cytotoxic Agents in <i>ERBB2</i> Amplified or Mutant Lung Cancers (2023)

&lt;p&gt;Supplementary Table 1&lt;/p&gt;
Advancing Toward HIV-1 Vaccine Efficacy through the Intersections of Immune Correlates (2013)

Interrogating immune correlates of infection risk for efficacious and non-efficacious HIV-1 vaccine clinical trials have provided hypotheses regarding the mechanisms of induction of protective immunity to HIV-1. To date, there have been six HIV-1 vaccine efficacy trials (VAX003, Vaxgen, Inc., San Francisco, CA, USA), VAX004 (Vaxgen, Inc.), HIV-1 Vaccine Trials Network (HVTN) 502 (Step), HVTN 503 (Phambili), RV144 (sponsored by the U.S. Military HIV Research Program, MHRP) and HVTN 505). Cellular, humoral, host genetic and virus sieve analyses of these human clinical trials each can provide information that may point to potentially protective mechanisms for vaccine-induced immunity. Critical to staying on the path toward development of an efficacious vaccine is utilizing information from previous human and non-human primate studies in concert with new discoveries of basic HIV-1 host-virus interactions. One way that past discoveries from correlate analyses can lead to novel inventions or new pathways toward vaccine efficacy is to examine the intersections where different components of the correlate analyses overlap (e.g., virus sieve analysis combined with humoral correlates) that can point to mechanistic hypotheses. Additionally, differences in durability among vaccine-induced T- and B-cell responses indicate that time post-vaccination is an important variable. Thus, understanding the nature of protective responses, the degree to which such responses have, or have not, as yet, been induced by previous vaccine trials and the design of strategies to induce durable T- and B-cell responses are critical to the development of a protective HIV-1 vaccine.
Using Honey to Heal Diabetic Foot Ulcers (2008)

Diabetic ulcers seem to be arrested in the inflammatory/proliferative stage of the healing process, allowing infection and inflammation to preclude healing. Antibiotic-resistant bacteria have become a major cause of infections, including diabetic foot infections. It is proposed here that the modern developments of an ancient and traditional treatment for wounds, dressing them with honey, provide the solution to the problem of getting diabetic ulcers to move on from the arrested state of healing. Honeys selected to have a high level of antibacterial activity have been shown to be very effective against antibiotic-resistant strains of bacteria in laboratory and clinical studies. The potent anti-inflammatory action of honey is also likely to play an important part in overcoming the impediment to healing that inflammation causes in diabetic ulcers, as is the antioxidant activity of honey. The action of honey in promotion of tissue regeneration through stimulation of angiogenesis and the growth of fibroblasts and epithelial cells, and its insulin-mimetic effect, would also be of benefit in stimulating the healing of diabetic ulcers. The availability of honey-impregnated dressings which conveniently hold honey in place on ulcers has provided a means of rapidly debriding ulcers and removing the bacterial burden so that good healing rates can be achieved with neuropathic ulcers. With ischemic ulcers, where healing cannot occur because of lack of tissue viability, these honey dressings keep the ulcers clean and prevent infection occurring.
EXAMINATION ABOUT INFLUENCE FOR PRECISION OF 3D IMAGE MEASUREMENT FROM THE GROUND CONTROL POINT MEASUREMENT AND SURFACE MATCHING (2015)

Abstract. As the 3D image measurement software is now widely used with the recent development of computer-vision technology, the 3D measurement from the image is now has acquired the application field from desktop objects as wide as the topography survey in large geographical areas. Especially, the orientation, which used to be a complicated process in the heretofore image measurement, can be now performed automatically by simply taking many pictures around the object. And in the case of fully textured object, the 3D measurement of surface features is now done all automatically from the orientated images, and greatly facilitated the acquisition of the dense 3D point cloud from images with high precision. With all this development in the background, in the case of small and the middle size objects, we are now furnishing the all-around 3D measurement by a single digital camera sold on the market. And we have also developed the technology of the topographical measurement with the air-borne images taken by a small UAV [1~5]. In this present study, in the case of the small size objects, we examine the accuracy of surface measurement (Matching) by the data of the experiments. And as to the topographic measurement, we examine the influence of GCP distribution on the accuracy by the data of the experiments. Besides, we examined the difference of the analytical results in each of the 3D image measurement software. This document reviews the processing flow of orientation and the 3D measurement of each software and explains the feature of the each software. And as to the verification of the precision of stereo-matching, we measured the test plane and the test sphere of the known form and assessed the result. As to the topography measurement, we used the air-borne image data photographed at the test field in Yadorigi of Matsuda City, Kanagawa Prefecture JAPAN. We have constructed Ground Control Point which measured by RTK-GPS and Total Station. And we show the results of analysis made in each of the 3D image measurement software. Further, we deepen the study on the influence of the distribution of GCP on the precision.
Change in TRP and TIS due to Handset Mounting Errors During Measurements (2004)

Abstract An important characteristic of a mobile handset is its ability to receive and transmit power. One way to characterize the performance of a handset in this respect is to use measurements of the spherical radiation pattern from which the total radiated power (TRP) and total isotropic sensitivity (TIS) can be computed. Often this kind of measurements are made with a phantom user head next to the handsets in order to simulate the inuence of a real user. The measured radiation patterns are only expected to be repeatable if the same setup is reproduced, i.e., the same phantom and the same mounting of the handset on the phantom. In this work the inuence of mounting errors on the TRP and TIS is investigated. Radiation patterns of six handsets have been measured while they were mounted at various offsets from the reference position dened by the Cellular Telecommunications &amp;amp; Internet Association (CTIA) certication. The change in the performance measures are investigated for both the GSM-900 and the GSM-1800 band.
Abstract 3910: Lead optimization of a series of 5-aminopyrazol-imidazopyridine compounds as potent anaplastic lymphoma kinase inhibitors active against clinically relevant ALK mutations (2012)

Abstract Despite the success of Crizotinib in treating NSCLC patients with EML4-ALK fusions, cancers eventually develop resistance via a variety of mechanisms including mutations in the ATP binding site of the kinase domain. A series of 5-aminopyrazol-imidazopyridine compounds were identified to potently inhibit anaplastic lymphoma kinase and were found to be active against a number of mutations in vitro but suffered from strong Cyp inhibition and were found to be metabolically unstable by incubation in human hepatocytes and microsomes. Installation of a pyrimary alcohol group on the heteroaryl ethyl group of the scaffold consistently improved Cyp3A4 liability, and led to improvement in physical and DMPK properties as well as improvement of their metabolic stability in human Heps. The lead compound from this series was orally administrated to SCID mice in a Del xenograft model and achieved greater than 90% phospho-ALK inhibition over 6 hours post dose at 10 mg/kg dose. The lead compound was subsequently tested against Crizotinib-resistant ALK mutations in enzyme assays, and was shown to inhibit the clinically relevant ALK mutations, including L1196M. In enzyme assays, it was inactive against G1269S mutation, consistent with modeling studies. Subsequent profiling in an FDCP cell line over expressing ALK G1269S mutation showed potent anti-proliferative activity, suggesting off-target activity. Further characterization of this series identified AurB inhibition to be a key cell cycle kinase responsible for the off-target activity in the engineered cell line. The off target activity hinders it from assessing the primary pharmacology responsible for its preclinical efficacy in disease relevant models. In conclusion, we have identified a novel orally bioavailable compound that is a potent dual active ALK and AurB inhibitor that is active against clinically-relevant gatekeeper mutant. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3910. doi:1538-7445.AM2012-3910
Multiscale modeling of chemical vapor deposition (1998)

An integrated method for modeling chemical vapor deposition on length scales ranging from microns to meters has been developed. The macroscale problem of flow and transport in a single wafer, low pressure chemical vapor deposition reactor is solved using the finite element method. However, on the feature scale, continuum models of flow and transport are not valid and discrete particle transport models must be employed. The two transport regimes, continuum and discrete particle, are linked by an effective reactivity function ε which includes both effects of multiscale surface heterogeneity and microscale transport resistance. A hybrid ballistic transport, Monte Carlo method, is developed permitting calculation of ε for any set of reaction pathways occurring over microelectronic device features of any geometry. Surface topography, that is, feature scale calculations, are combined to yield an effective reactivity map over the surface of the substrate. This map is subsequently used to formulate a flux boundary condition on the macroscopic model. Iteration between macroscopic and microscopic models is used to assure a consistent set of conditions at the macro–micro interface. The resulting linked models are used for investigation of local and reactor wide loading effects. Matched macroscopic solutions provide inputs for profile evolution calculations during fill of trenches and vias.
Correlation of Cytogenetic Findings with Morphology, Clinical Course and Prognosis in 2124 Patients with MDS. (2005)

Abstract Cytogenetic abnormalities are observed in 30%–80% of MDS pts and correlate with morphologic features, clinical course, prognosis, and response to therapy. Cytogenetic heterogeneity hampers investigation, and little is known about rarer abnormalities and combinations of abnormalities. Furthermore, it has not yet been possible to compare the effects of different therapies within cytogenetic entities. To address such issues, we have generated a large, unique database comprising morphologic, clinical, cytogenetic, and follow-up data from MDS pts at 8 institutions in Austria and Germany. So far, we have data on 2124 pts with a median age of 65.7 yr and a male: female ratio of 1.29. 1981 pts (93.3%) had primary and 143 had secondary MDS. FAB classification of pts: RA 589 (27.7%); RARS 256 (12.1%); RAEB 424 (20%); RAEB-T 311 (14.6%); CMML 287 (13.5%); MDS-AL 132 (4.2%). WHO classification (available in 595 pts): 5q- syndrome 71 (11.9%); RA 46 (7.7%); RARS 26 (4.4%); RCMD 164 (27.6%); RSCMD 77 (12.9%); RAEB-I 90 (15.1%); RAEB-II 121 (20.3%). Cytogenetic analyses were successful in 2072 pts (97.6%) with a mean of 21.9 completely analyzed metaphases. The mean number of aberrations per case was 1.52. 1080 pts (52.1%) had clonal abnormalities. Cytogenetic characteristics are shown in Figure 1. IPSS cytogenetic risk: good 1217 pts (58.7%); intermediate 401 (19.4%); unfavorable: 454 (21.9%). Follow-up data were available in 1841 pts for a mean of 29.2 mo. Supportive care was given to 1286 pts (60.6%), chemotherapy to 462 (21.8%), amifostine to 22 (0.1%), and therapeutic data were unavailable in 354. Median survival by IPSS cytogenetic risk, karyotype complexity, and influence of additional cytogenetic abnormalities in patients with isolated 5q deletion and trisomy 8 are shown in Table 1. Prognostic data of other isolated and combined abnormalities (-7,-20/20q-,-Y) as well as rarer abnormalities (3q, 9q-, +11, -12/12p-, -13/13q-, -17/17p-, +21 and others) will be presented, as will the influence of different therapies on survival in genetic entities. By FAB classification, there were no significant differences in the distribution of cytogenetic risk groups between RA and RARS and between RAEB and RAEB-T. By WHO classification, the 5q- syndrome exclusively displayed favorable karyotypes; no unfavorable abnormalities were observed in RARS (WHO) in contrast to RARS (FAB), and no significant differences were observed between RAEB-I and RAEB-II. In conclusion, additional abnormalities modulate the prognostic value of the primary cytogenetic changes in different ways that have to be delineated for each abnormality. Since novel therapies such as IMiDs/lenalidomide are effective in distinct cytogenetic entities, a better knowledge of cytogenetically defined subgroups is urgently needed. Figure 1, Table 1 Figure 1, Table 1.
Chemical Synthesis, 3D Structure, and ASIC Binding Site of the Toxin Mambalgin‐2 (2013)

Abstract Mambalgins are a novel class of snake venom components that exert potent analgesic effects mediated through the inhibition of acid‐sensing ion channels (ASICs). The 57‐residue polypeptide mambalgin‐2 (Ma‐2) was synthesized by using a combination of solid‐phase peptide synthesis and native chemical ligation. The structure of the synthetic toxin, determined using homonuclear NMR, revealed an unusual three‐finger toxin fold reminiscent of functionally unrelated snake toxins. Electrophysiological analysis of Ma‐2 on wild‐type and mutant ASIC1a receptors allowed us to identify α‐helix 5, which borders on the functionally critical acidic pocket of the channel, as a major part of the Ma‐2 binding site. This region is also crucial for the interaction of ASIC1a with the spider toxin PcTx1, thus suggesting that the binding sites for these toxins substantially overlap. This work lays the foundation for structure–activity relationship (SAR) studies and further development of this promising analgesic peptide.
The urgent need for integrated science to fight COVID-19 pandemic and beyond (2020)

The COVID-19 pandemic has become the leading societal concern. The pandemic has shown that the public health concern is not only a medical problem, but also affects society as a whole; so, it has also become the leading scientific concern. We discuss in this treatise the importance of bringing the world's scientists together to find effective solutions for controlling the pandemic. By applying novel research frameworks, interdisciplinary collaboration promises to manage the pandemic's consequences and prevent recurrences of similar pandemics.
A compact directive antenna combining metamaterial collimating lens and artificial magnetic ground plane (2012)

As an extension to previous work on flat metamaterial lenses for antenna gain enhancement, we present a dual-metamaterial design for a far-field collimating lens using an artificial magnetic conducting (AMC) ground plane to reduce the antenna profile by 20%. Simulations show good radiation performance over a 10% bandwidth.
A Bleustein-Gulyaev-Shimizu wave resonator having resonances for TV and VCR traps (2002)

A Bleustein-Gulyaev-Shimizu (BGS) wave has only a shear horizontal (SH) wave showing a complete reflection at a free edge of a substrate. In this paper, using the responses exited by a weighted interdigital transducer (IDT) and generated by the 2N/spl plusmn/2th mode complete reflections at free edges of a ceramic substrate, we realized a new type of BGS resonator having three resonances without reflector electrodes. This resonator showed sufficient trap attenuations for practical use at both adjacent picture carrier frequency (fap) and adjacent sound carrier frequency (fas) in the TV/VCR VIF (video intermediate frequency) circuit.
Supplemental figure 1 from Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies (2023)

&lt;p&gt;BRD4 binding to Myc regulatory region&lt;/p&gt;
L-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine, autotaxin (2005)

L-histidine inhibition of LPLD is not a simple stoichiometric chelation of metal ions but is more likely a complex interaction with a variety of moieties, including the metal cation, at or near the active site. The inhibitory effect of L-histidine requires all three major functional groups of histidine: the alpha amino group, the alpha carboxyl group, and the metal-binding imidazole side chain. Because of LPA's involvement in pathological processes, regulation of its formation by ATX may give insight into possible novel therapeutic approaches.
Mixing and Dispersion in Small-Scale Flow Systems (2012)

Continuous flow chemistry is being used increasingly; however, without detailed knowledge of reaction engineering, it can be difficult to judge whether dispersion and mixing are important factors on reaction outcome. Understanding these effects can result in improved choices of reactor dimensions and give insight for reactor scale-up. We provide an overview of both dispersive and mixing effects in flow systems and present simple relationships for determining whether mixing or dispersion is important for a given flow system. These results are summarized in convenient charts to enable the experimentalist to identify conditions with potential mixing or dispersion problems. The information also expedites design changes, such as inclusion or changes of mixers and changes in reaction tube diameters. As a case study, application of the principles to a glycosylation reaction results in increased throughput and cleaner product profiles compared to previously reported results.
Primary total knee arthroplasty in patients with post-polio syndrome (2023)

TKAs in post-polio patients are complex cases associated with instability, and one in four require constraint on the affected side. Periprosthetic fracture was the main mode of failure. Arthrofibrosis rates were high and twice as frequent in affected limbs.
Demonstration of a NV spin qubit interacting with a cavity mode in the Purcell regime (2014)

We demonstrate an over-80-fold enhancement of an NV’s zero-phonon line emission inside cavity in the Purcell regime within a high-purity, electronic-grade diamond substrate. This system is a promising building block for quantum networks.