gebhart/patrepeval huggingface dataset:
Formage magnétique de raidisseurs pour composants aéronautiques (2019)

Les industriels de l'aeronautique concoivent et fabriquent de nombreux composants de petite (Lmax < 200 mm) et de moyenne taille (200 mm < Lmax < 1000 mm) par elastoformage. Pour diversifier les moyens de productions de ces composants, cette etude propose d'evaluer la capacite du procede de formage magnetique a produire des composants de petite taille. Le materiau utilise ici est l'aluminium 2024-T4 et les plaques ont une epaisseur de 1, 2 ou 1,6 mm. Bien qu'il existe des centaines de references pour ces composants aeronautiques, ils sont tous concus a partir d'un nombre limite de geometries elementaires: bord tombe droit (BT1) ou droit interrompu (BT2), soyage (BT3), bord tombe concave (BT4) ou convexe (BT5), et trou bord tombe (BT6). Chaque geometrie necessite la conception d'un inducteur et d'une matrice specifique. La dispersion geometrique des pieces obtenues ainsi que leur integrite ont ete controlees et mesurees. La conception des outillages et des inducteurs a ete optimisee via des modeles numeriques developpes avec l'environnement de calcul LS-DYNA. Une premiere comparaison qualitative montre un accord entre les resultats experimentaux et numeriques.
A tube-MOT of cesium atoms for loading microstructures (2002)

Summary form only given. The magneto-optical trap (MOT) has become the workhorse for many, if not most atom-optics experiments. The traditional MOT uses a pair of coils in anti-Helmholtz configuration to generate a quadrupole field with a typical gradient in the order of 10 Gauss/cm and a typical MOT diameter of 1 mm. In this paper we describe the formation of a surface MOT in a skewed magnetic field, produced by a magnetic laminate.We have imaged the fluorescence of the trapped cloud onto a CCD camera, and made cross sections of the trapped atom cloud.
Multi-Component Protein Complexes and Golgi Membrane Trafficking (2005)

Several large cytosolic protein complexes with multiple components have been proposed to play key roles in mediating or controlling membrane trafficking. Among these complexes, TRAPP, COG and GARP/VFT have been implicated in multiple steps of Golgi membrane trafficking. The importance of these complexes for Golgi function has been established using in vitro biochemical assays and yeast and mammalian somatic cell genetics. Furthermore, mutations in the genes encoding subunits of either TRAPP or the COG complex have been shown to be responsible for human genetic disorders. We here review recent studies exploring the structures and functions of these three oligomeric complexes.
Gender-Inclusive HCI Research and Design: A Conceptual Review (2020)

Previous research has investigated gender and its implications for HCI. We consider inclusive design of technology whatever the gender of its users of particular importance. This conceptual review provides an overview of the motivations that have driven research in gender and inclusive HCI design. We review the empirical evidence for the impact of gender in thinking and behavior which underlies HCI research and design. We then present how HCI design might inadvertently embed and perpetuate gender stereotypes. We then present current HCI design approaches to tackle gender stereotypes and to produce gender-inclusive designs. We conclude by discussing possible future directions in this area.
Coupling in the absence of tertiary amines (1982)

In order to avoid base catalyzed side reactions during coupling, attempts were made to render superfluous the addition of tertiary amines to the reaction mixture. Weak acids were applied for the removal of acid labile protecting groups. Acetic acid and other carboxylic acids were considered unsuitable for this purpose coupling step. Pentachlorophenol and 2,4-dinitrophenol cleaved the Bpoc, Nps and Trt groups but more practical rates were reached with solutions of 1-hydroxybenzotriazole (HOBt) in trifluoroethanol, in acetic acid, or in a mixture of phenol and p-cresol. In addition to acidolysis, HOBt salts of amino components could also be obtained through hydrogenolysis of the Z group or thiolysis of the Nps group in the presence of HOBt, or by the displacement of acetic acid from acetate salts with HOBt. Acylation of HOBt salts of amino components with symmetrical or mixed anhydrides or with active esters did not require the addition of tertiary amine.
Does Modality Matter? The Effects of Reading, Listening, and Dual Modality on Comprehension (2016)

With advancing technology, there is increasing interest in differences between listening versus reading comprehension or doing both simultaneously. Ninety-one participants were randomly assigned to one of three groups that received the same instructional material (the preface and a chapter from a non-fiction book), but each in a different input modality (digital audiobook, e-text, dual modality). After completing the material, participants took the same comprehension test in written form to establish both immediate comprehension (Time 1) and 2-week retention (Time 2). No statistically significant differences were found for any analyses pertaining to effects of the three different instructional conditions on comprehension at Time 1 or Time 2. Additional analyses showed that both males and females in each condition recalled an equal amount of information, regardless of whether they listened to an audiobook, read from an electronic tablet, or both listened and read simultaneously (dual modality).
Ultrafast THz spectroscopy of carbon nanotube-graphene composites (2023)

Mixed nanomaterial composites can combine the excellent properties of well-known low-dimensional nanomaterials. Here we highlight the potential of one-dimensional single-walled carbon nanotubes interfaced with two-dimensional graphene by exploring the composite's ac conductivity and photoconductivity, and the influence of HAuCl<sub>4</sub>doping. In the composite, the equilibrium terahertz conductivity from free carrier motion was boosted, while the localised plasmon peak shifted towards higher frequencies, which we attribute to shorter conductivity pathways in the composite. A negative terahertz photoconductivity was observed for all samples under 410 nm optical excitation and was reproduced by a simple model, where the Drude spectral weight and the momentum scattering rate were both lowered under photoexcitation. The composite had an enhanced modulation depth in comparison to reference carbon nanotube films, while retaining their characteristically fast (picosecond) response time. The results show that carbon nanotube-graphene composites offer new opportunities in devices by controlling charge carrier transport and tuning their optoelectronic properties.
Metal-Centered Photoinduced Electron Transfer Reduction of a Gold(III) Porphyrin Cation Linked with a Zinc Porphyrin to Produce a Long-Lived Charge-Separated State in Nonpolar Solvents (2003)

Photoexcitation of an electron donor-acceptor linked dyad containing gold(III) and zinc(II) porphyrins (ZnPQ-AuIIIPQ+) results in electron transfer from the singlet excited state of ZnPQ to the metal center of AuPQ+ to produce the charge-separated state (ZnPQ*+-AuIIPQ) which has a long lifetime (10 mus) in nonpolar solvents such as cyclohexane and toluene.
AMERICANS WITH DISABILITIES ACT (ADA) BETWEEN CAR BARRIERS (2003)

When the Americans with Disabilities Act (ADA) was introduced in 1990, one of the specific regulations included regulated between car barriers (BCB) for light and heavy rails. The objective of between car barriers was to encourage everyone, including the disabled people, to confidently use the transportation system, designed with complete safety for everyone. This paper discusses the development of a prototype unit to meet the intent of the ADA. The design was given high consideration for safety, reliability and operational constraints. Before implementation, items such as rain impact, sharp turns, speed of the car, rubbing against car body, attachment to car body for stability, toxicity, flammability, labor time for removal and replacement of BCB devices were considered in many configurations. The progressive design modifications, prototype construction and testing in the field has improved and evolved the design to current level.
Stromal Cross-Presentation and Host Interferon-γ Signaling and Are Required for Elimination of Antigen-Loss Variants of High-Grade B Cell Lymphomas: Implications for Adoptive T Cell Therapy (2010)

Abstract Abstract 3927 The incidence of high-grade B cell lymphomas has been increasing over the last decades in western countries for unclear reasons. Relapse after conventional chemotherapy especially in high-grade B cell lymphomas remains a very difficult clinical issue. Contrary to CML and AML, the benefit of allogeneic SCT for treatment of high-grade lymphomas is not well established. Several studies suggested a potential graft versus lymphoma (GvL) effect for acute lymphoblastic leukemia (ALL) and several types of non-Hodgkin lymphomas. To study mechanisms involved in T cell-mediated rejection of B cell lymphomas, we have developed a murine lymphoma model in which three antigens, human c-MYC protein, chicken ovalbumin (OVA) and GFP, serve as foreign antigens for rejection. Lymphomas expressing all three antigens were rejected in 60 to 70% of animals after transfer into wild type mice, whereas lymphomas expressing only human c-MYC protein were not rejected. Outgrowing OVA-expressing lymphomas were infiltrated by T cells, showed MHC class I and II upregulation and loss of antigen expression, indicating immune escape. In contrast to wild type recipients of OVA-expressing lymphomas, 80 to 100% of recipient STAT1-, IFN-γ-, or IFN-γ receptor-deficient mice died due to lymphoma growth. Remarkably, lymphomas arising in IFN-γ- and IFN-γ-receptor-deficient mice also invariably showed lost antigen expression. Thus, poor overall survival of IFN-γ- and IFN-γ-receptor-deficient recipient mice is not due to a lack of antigen-specific T cell killing but due to inefficient eradication of antigen-negative variants of the lymphoma. In order to address the role of the stroma in eradication of lymphoma cells we made use of B6bm1 animals that do not present the immunodominant OVA derived peptide SIINFEKL in the context of MHC class I. Since the wildtype MHC represents an allo-antigen in B6bm1 mice, B6bm1 and B6 wildtype control recipients were T-cell depleted by 30H12 anti CD90.2 antibody prior to transfer of lymphoma cells. Anti OVA immunity was restored by adoptive transfer of 1 Mio. primed CD90.1+ OT-I-T-cells one day after lymphoma transfer. T-cell depletion was continued for 28 days biweekly. Lymphoma growth was faster in bm1 recipients and disease free survival significantly reduced (A). In addition, T-cell expansion was significantly reduced (B) in bm1 recipients as analyzed by pentamer staining of OT-I-T-cells in peripheral blood (day 21 0.84%±0.2 vs. 3.53%±0.2 of lymphocytes, p=0.001) indicating an important role of stromal crosspresentation for the rejection of lymphoma cells. Our data show that mechanisms established for solid tumors hold true also for hematologic neoplasias such as B cell lymphomas. Antigen-dependent eradication of tumor antigen-loss variants makes antigen-specific T cell therapy particularly attractive as a novel therapeutic treatment option. Disclosures: No relevant conflicts of interest to declare.
Block linear coherent detection of optical continuous phase modulation (2010)

Continuous phase modulation (CPM) of optical links is advantageous for avoiding intensity dependent nonlinear phase noise. We present an architecture for all-digital coherent CPM reception covering M-ary full response formats, describing the functions of each module.
Beta-1 adrenergic inhibition of kallikrein release from rat kidney cortical slices (1990)

Renal storage; release, and biosynthesis of kallikrein were studied using rat cortical slices. This model permitted the study of the direct effect of norepinephrine on the renal kallikrein system in the absence of changes in perfusion pressure. Kallikrein was measured by its kininogenase activity and its direct immunoreactive concentration. Under basal conditions, rat kidney cortical slices synthesize and release glandular kallikrein in vitro at a linear rate for up to 40 min. Kidney slices obtained from rats fed with a low-sodium diet (LS) released more kallikrein into the incubation medium than slices from rats under a normal-sodium diet (NS). Cycloheximide and incubation at 4 degrees C inhibited the release and the biosynthesis of kallikrein independently of the sodium diet. Addition of norepinephrine (NE, 10(-8)-10(-5) M) induced a similar dose-dependent inhibition of kallikrein secretion, which reached -27 +/- 8% in NS rats and -29 +/- 9% in LS rats with 10(-7) M NE. This inhibition of the secretion was associated with an increase in tissue kallikrein concentration in kidney slices from rats on both sodium diets. However, a significant inhibition of the calculated net de novo synthesis was only observed in LS rats. In both groups of animals the ratio of active to total kallikrein was unchanged. The inhibitory effect of kallikrein secretion by NE was never modified in the presence of the alpha-antagonist phentolamine (10(-6) M). In contrast the beta-antagonist propranolol (10(-6) M) prevented the inhibitory effect of 10(-7) M NE.(ABSTRACT TRUNCATED AT 250 WORDS)
Transmutations et traces de monopôles obtenues lors de d´echarges ´electriques (2009)

8 pages
Hyponymy Relation Acquisition from Hierarchical Layouts in Wikipedia (2009)

本稿では，Wikipedia の記事構造を知識源として，高精度で大量の上位下位関係を自動獲得する手法について述べる．上位下位関係は情報検索や Web ディレクトリなど，膨大な Web 文書へのアクセスを容易にする様々な技術への応用が期待されており，これまでにも様々な上位下位関係の抽出手法が開発されてきた．本稿では，Wikipedia の記事構造に含まれる節や箇条書きの見出しから，大量の上位下位関係候補を抽出し，機械学習を用いてフィルタリングすることで高精度の上位下位関係を獲得する手法を開発した．実験では，2007 年 3 月の日本語版 Wikipedia 2.2 GB から，約 77 万語を含む約 135 万対の上位下位関係を精度 90% で獲得することができた．
Plasma Soluble Corin in Patients With Heart Failure (2010)

Soluble corin was detected in human plasma. Plasma corin levels were reduced significantly in patients with HF but not in those with acute myocardial infarction. Our results indicate that corin deficiency may contribute to the pathogenesis of HF and that plasma corin may be used as a biomarker in the diagnosis of HF.
Revisiting Charge Trapping/Detrapping in Flash Memories From a Discrete and Statistical Standpoint—Part I: \(V_{T}\) Instabilities (2014)

This paper and the corresponding Part II [1] revisit charge trapping and detrapping in Flash memories considering some major features of the phenomenon which have been clearly detected on nanoscale technologies: charge discreteness, statistical charge capture and emission, statistical distribution of the threshold-voltage shift following a charge capture/emission event, and spectral distribution of the detrapping time constants over many decades of time. In this Part I, we address threshold-voltage instabilities following charge detrapping from the cell tunnel oxide, highlighting their statistical properties and coming to a powerful formula for their quantitative analysis. These results pave the way to the development of a comprehensive statistical model able to deal with charge trapping/detrapping during whatever on-field array operation, representing the topic of Part II.
Innovative molecular-based fluorescent nanoparticles for multicolor single particle tracking in cells (2016)

Based on an original molecular-based design we present bright and photostable fluorescent organic nanoparticles (FONs) with an excellent colloidal stability in various aqueous environments. Near-infrared emitting and green emitting FONs were prepared using a simple and robust protocol. Both types of FONs could be simultaneously imaged at the single-particle level in solution as well as in biological environments using a monochromatic excitation and a dual-color fluorescence microscope. No evidence of acute cytotoxicity was found upon incubation of live cells with mixed solutions of FONs, and both types of nanoparticles were found internalized in the cells where their movements could be simultaneously tracked at video-rate up to minutes. These fluorescent FONs open a novel non-toxic alternative to existing nanoparticles for imaging biological structures, compatible with live-cell experiments and specially fitted for multicolor single particle tracking.
Intrusion Detection Using Execution Contexts Learned from System Call Distributions of Real-Time Embedded Systems. (2015)

The increasing number of security threats faced by real-time embedded systems requires the development of effective intrusion detection mechanisms. However, the limited resources in such systems, viz., computational power and storage, prevent current techniques from being effective. In this paper, we propose a lightweight method with a deterministic time complexity for detecting anomalous executions using a distribution of system call frequencies, i.e., the number of occurrences of each system call type during execution. We use the global k-means clustering with the Mahalanobis distance to learn the legitimate execution contexts of real-time embedded applications and then monitor them at run-time to detect intrusions. We also present minor processor modifications to aid in this process. Initial prototypes show that the proposed method can effectively detect anomalous executions without relying on overly sophisticated analyses. It can also detect certain attacks that current methods fail to do so.
Surfactant and cation effects on the electrochemical reduction of an .alpha.,.beta.-unsaturated ketone (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSurfactant and cation effects on the electrochemical reduction of an .alpha.,.beta.-unsaturated ketoneDavid A. Jaeger, Durgadas Bolikal, and Buddhadeb NathCite this: J. Org. Chem. 1987, 52, 2, 276–278Publication Date (Print):January 1, 1987Publication History Published online1 May 2002Published inissue 1 January 1987https://pubs.acs.org/doi/10.1021/jo00378a021https://doi.org/10.1021/jo00378a021research-articleACS PublicationsRequest reuse permissionsArticle Views125Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Abstract 2644: Inhibition of PAK4 attenuates renal cell carcinoma (RCC) growth (2015)

Abstract Renal cell carcinoma (RCC) is an increasingly prevalent cancer type that is frequently asymptomatic on presentation and is associated with poor responses and resistance even to the current targeted therapies. Thus, novel therapeutic approaches to treat this disease are urgently needed. P21-activated kinase 4 (PAK4) is a mediator of filopodia formation and stabilizes β-catenin transcriptional activity. PAK4 lies in a pathway integral to both nephrogenesis and cancer. We hypothesized that inhibitors of the PAK4 signaling pathway would result in salutary effects on RCC. To test this, we evaluated the in vitro response of RCC cells to the specific PAK4 Allosteric Modulators (PAMs; KPT-8752 and KPT-9274). Similar to cells of other cancer types, 786-O (VHL-mutant RCC) showed decreases of both Phospho-PAK4 and Phospho-β-catenin after 24 h of incubation with 10 μM KPT-8752. In addition, both 786-O and ACHN (VHL-wildtype RCC cells) showed a marked time-dependent decrease in cell viability from 24 to 72 h of incubation from 2 to 10 μM of KPT-8752. KPT-9274 was orally administered at 25 and 100 mg/kg twice a day for 5 days/week to Caki-1 (VHL-wildtype RCC) and 786-O subcutaneous nude mouse xenograft models. In these studies the tumor growth rate was attenuated at both doses in the 786-O cells and at the higher dose for Caki-1 cells. There was no obvious change in the health of any of the animals suggesting manageable tolerability. We are currently evaluating combination therapy in our laboratory. In summary, PAK4 inhibitors show considerable promise as novel treatments of RCC as a single agent and warrant further investigation. Citation Format: Omran Abu Aboud, William Senapedis, Yosef Landesman, Erkan Baloglu, Robert H. Weiss. Inhibition of PAK4 attenuates renal cell carcinoma (RCC) growth. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2644. doi:10.1158/1538-7445.AM2015-2644
11beta-hydroxysteroid dehydrogenase type 1 in obese children (2007)

Objective: The incidence of childhood obesity and type 2 diabetes has reached epidemic proportions. Glucocorticoid excess causes central obesity and diabetes mellitus as seen in Cushing's syndrome. The 11beta-Hydroxysteroid dehydrogenase type 1 enzyme (11beta-HSD1), which is predominantly expressed in liver and adipose tissue, regenerates active cortisol from inactive cortisone. Increased 11beta-HSD1 may cause tissue-specific Cushing syndrome with central obesity and impaired glucose homeostasis.
Immunoprophylaxis againstMycobacterium lepraeinfection with subunit vaccines (2000)

We have investigated the effect of subunit vaccines against infection with Mycobacterium leprae, employing DNA plasmids as the vaccine vectors, and the immunodominant 35 kDa protein of M. leprae as the candidate antigen. A DNA vaccine that expresses the M. leprae 35 kDa protein both stimulated interferon-,), (IFN,),)-secreting T cells in mice, and demonstrated protection against M. leprae-infection of mice.
Stromal Cell-Mediated Stimulation of Osteoclastogenesis (1994)

In the bone marrow microenvironment, stromal cells or their products are known to regulate proliferation and differentiation of hematopoietic stem cells. The purpose of this investigation was to characterize stroma-mediated effects of differentiation-inducing factors on osteoclastogenesis in defined murine cultures. Hematopoietic progenitors (derived from long-term bone marrow cultures, LTBMCs) were cocultured with cloned stromal cell lines to demonstrate the indirect effects of various differentiation-inducing factors. Osteoclastogenesis was compared in three murine marrow systems (whole bone marrow, progenitors cultured alone, and cocultures of progenitors with stromal cell lines) by analysis of multinuclearity and tartrateresistant acid phosphatase (TRAP) activity. The cultures were treated for two weeks with murine recombinant GM-CSF (5 U/ml), 1,25-dihydroxyvitamin D3 (10(-8) M), or parathyroid hormone (PTH, 10(-8) M). In whole bone marrow cultures, osteoclast differentiation was stimulated by GM-CSF, PTH and 1,25-dihydroxyvitamin D3. With progenitors alone, only GM-CSF promoted osteoclastogenesis. Each agent stimulated osteoclastogenesis in cocultures of progenitors with a stromal cell line (GBLneo'). Thus, the coculture system is a partially defined model for whole bone marrow cultures. In contrast, progenitors that were cocultured with a stromal cell line derived from an osteopetrotic op/op mouse failed to differentiate in the presence of PTH or 1,25-dihydroxyvitamin D3. These results indicate that stimulation of osteoclastogenesis by PTH or 1,25-dihydroxyvitamin D3 is mediated indirectly through factors present in normal marrow stromal cells and that an osteopetrotic stromal cell line failed to support differentiation.