gebhart/patrepeval huggingface dataset:
Cavitation-enhanced delivery of macromolecules into an obstructed vessel (2010)

Poor drug penetration through tumor tissue has emerged as a fundamental obstacle to cancer therapy. The aim of this study was to examine the ability of cavitation instigated by high-intensity focused ultrasound (HIFU) to increase convective transport of a model therapeutic in an in vitro tumor model. Cavitation activity was quantified by analyzing passively recorded acoustic emissions, and mass transfer was quantified using post-treatment image analysis of the distribution of a dye-labeled macromolecule. The strong correlation between cavitation activity and drug delivery suggests the potential for non-invasive treatment and monitoring.
Evaluation of HIV-1 p24 Antigenemia and Level of CD8+CD38+ T cells as Surrogate Markers of HIV-1 RNA Viral Load in HIV-1-Infected Patients in Dakar, Senegal (2006)

Alternative, affordable, and simple assays to monitor antiretroviral therapy (ART) in resource-poor settings are needed. We have evaluated and compared a heat-denatured (HD) HIV p24 amplified enzyme-linked immunosorbent assay from Perkin-Elmer and CD38CD8 T-cell levels, determined by flow cytometry, for their capacity to predict viral load (VL) in HIV-1-infected patients from Senegal. Median fluorescence intensity (MFI) of CD38 expression on memory (CD45RO) CD8 T cells correlated better with RNA VL than HD p24 antigenemia (R = 0.576, P < 0.0001 vs R = 0.548, P < 0.0001). MFI of CD38 expression on memory CD8 T cells could predict detectable RNA VL (VL = 2.6 log10) with a sensitivity of 87% and a specificity of 74%. A comparable sensitivity (89%) could be reached for HD p24 assay, but only to predict RNA VL of more than 5 logs, which might lead to unacceptable delays in clinical decision making. The clinical use of the HD p24 assay to monitor ART in Senegal would require more comparative data about the kinetics of p24 antigen and HIV RNA in peripheral blood as well as further evaluation regarding its sensitivity toward subtype A and CRF02. MFI of CD38 expression on memory CD8 T cells appeared to be a better alternative to monitor ART in HIV-infected patients from Senegal.
Structure−Activity Studies on Anticonvulsant Sugar Sulfamates Related to Topiramate. Enhanced Potency with Cyclic Sulfate Derivatives. (2003)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionStructure−Activity Studies on Anticonvulsant Sugar Sulfamates Related to Topiramate. Enhanced Potency with Cyclic Sulfate Derivatives.Bruce E. Maryanoff, Michael J. Costanzo, Samuel O. Nortey, Michael N. Greco, Richard P. Shank, James J. Schupsky, Marta P. Ortegon, and Jeffry L. VaughtCite this: J. Med. Chem. 2003, 46, 4, 652Publication Date (Web):January 18, 2003Publication History Published online18 January 2003Published inissue 1 February 2003https://pubs.acs.org/doi/10.1021/jm020527hhttps://doi.org/10.1021/jm020527hcorrectionACS PublicationsCopyright © 2003 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views425Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (14 KB) Get e-Alertsclose Get e-Alerts
21.3: New Metric for Display Color Gamut Evaluation (2007)

Abstract We suggest a metric for evaluating color gamut of displays based on summing the probability of using a certain part of the display color gamut multiplied by an impact parameter for that color region. We further present methods for evaluating the probability of use, and the impact of color.
Supplementary Data from The E3 Ligase MIB1 Promotes Proteasomal Degradation of NRF2 and Sensitizes Lung Cancer Cells to Ferroptosis (2023)

&lt;p&gt;S1. qRT-PCR analysis in A549. S2. Rescue of H2O2 induced cell death in WT and MIB1 overexpression A549 cells. S3. A549 cells with MIB1 overexpression is more sensitive to RSL3 treatment in mouse xenograft model. S4. Illustration of hMIB1 and hNRF2 mutants used in this study. S5. NRF2 ubiquitination level is reduced in MIB1 knockout MDA-MB-231 cells. Table S1. List of PCR primers used in this study; Table S2. List of antibodies used in this study.&lt;/p&gt;
Tip‐enhanced Raman spectroscopy – an interlaboratory reproducibility and comparison study (2014)

Since its first experimental realization, tip‐enhanced Raman spectroscopy (TERS) has emerged as a potentially powerful nanochemical analysis tool. However, questions about the comparability and reproducibility of TERS data have emerged. This interlaboratory comparison study addresses these issues by bringing together different TERS groups to perform TERS measurements on nominally identical samples. Based on the spectra obtained, the absolute and relative peak positions, number of bands, peak intensity ratios, and comparability to reference Raman and surface‐enhanced Raman spectroscopy (SERS) data are discussed. Our general findings are that all research groups obtained similar spectral patterns, irrespective of the setup or tip that was used. The TERS (and SERS) spectra consistently showed fewer bands than the conventional Raman spectrum. When comparing these three methods, the spectral pattern match and substance identification is readily possible. Absolute and relative peak positions of the three major signals of thiophenol scattered by 19 and 9 cm −1 , respectively, which can probably be attributed to different spectrometer calibrations. However, within the same group (but between different tips), the signals only scattered by 3 cm −1 on average. This study demonstrated the suitability of TERS as an analytical tool and brings TERS a big step forward to becoming a routine technique. Copyright © 2014 John Wiley &amp; Sons, Ltd.
Torque and Speed Response Differences Between Deadbeat-Direct Torque and Flux Control and Indirect Field Oriented Control for Induction Machine Drives (2018)

Indirect field oriented control (IFOC) is widely used in induction machine (IM) drives. IFOC controls torque and rotor flux linkage by using an embedded current regulator. The torque and speed response are limited by current regulator bandwidth. Different from IFOC, without any current regulator, deadbeat-direct torque and flux control (DB-DTFC) calculates the voltage commands directly, which can achieve torque commands within just one switching period. However, high frequency torque and speed response have not been systematically discussed. First, IFOC, DB-DTFC algorithm and implementation issues are discussed in details. Then, the metric for evaluating the high frequency torque and speed response are proposed and evaluated. In the torque response, the DB-DTFC drive shows higher torque command tracking bandwidth with linear phase lag compared to IFOC drive. In the speed response, parameter sensitivities of high frequency speed command tracking for the two control algorithms are compared with encoder feedback. Finally, the speed response in the self-sensing mode for the two control algorithms are also compared.
Molecular Evolution of Proadrenomedullin N-Terminal 20 Peptide (PAMP): Evidence for Gene Co-Option (2006)

Posttranslational processing of proadrenomedullin generates two biologically active peptides, adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP). Sequence comparison of homologous proadrenomedullin genes in vertebrate evolution shows a high degree of stability in the reading frame for AM, whereas PAMP sequence changes rapidly. Here we investigate the functional significance of PAMP phylogenetic variation studying two of PAMP's better characterized physiological activities, angiogenic potential and antimicrobial capability, with synthetic peptides carrying the predicted sequence for human, mouse, chicken, and fish PAMP. All tested peptides induced angiogenesis when compared with untreated controls, but chicken and fish PAMP, which lack terminal amidation, were apparently less angiogenic than their human and mouse homologs. Confirming the role of amidation in angiogenesis, Gly-extended and free acid variants of human PAMP produced responses similar to the natural nonamidated peptides. In contrast, antimicrobial activity was restricted to human PAMP, indicating that this function may have been acquired at a late time during the evolution of PAMP. Interestingly, free acid human PAMP retained antimicrobial activity whereas the Gly-extended form did not. This fact may reflect the need for maintaining a tightly defined structural conformation in the pore-forming mechanism proposed for these antimicrobial agents. The evolution of PAMP provides an example of an angiogenic peptide that developed antimicrobial capabilities without losing its original function.
Serum Albumin Predicts Survival and Postoperative Course Following Surgery for Geriatric Hip Fracture (2017)

Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
The role of hyaluronic acid in protecting surface‐active phospholipids from lysis by exogenous phospholipase A2 (2001)

It is reasonable to assume that HA plays an important indirect role in the steady state of the boundary lubrication process of joints by protecting SAPL from being lysed by PLA(2). However, as excessive loading generates free radicals within the joint (among other effects), the HA that is degraded in this way is incapable of protecting SAPL from lysis by PLA(2). When the rate of degradation exceeds that of synthesis, there will be insufficient replacement of HA and/or SAPL, resulting in denudation of the articular surfaces. These are then exposed to increasing friction, and hence increased danger of degenerative joint changes.
Differentiation of the structural features of melanotropins important for biological potency and prolonged activity in vitro (1983)

Several α‐melanotropin (α‐MSH) analogues have been synthesized and tested for their melanotropin activities in order to determine the functional importance of certain amino acids near the primary active sequence of α‐MSH, H‐(Glu)‐His‐Phe‐Arg‐Trp‐Gly‐OH, on the biological activities of the hormone. In particular, we have examined the importance of the 4 and 11 positions in conjunction with the substitution of l ‐Phe in position 7 by d ‐Phe on potency and prolonged activity of the hormone. In the frog ( Rana pipiens ) skin system the relative potencies were found to be: [Nle 4 , d ‐Phe 7 ]‐α‐MSH (60) &gt; α‐MSH (1.0) &gt; Ac‐[Nle 4 , d ‐Phe 7 ]‐α‐MSH 4–11 ‐NH 2 (0.16) &gt; Ac‐[Nle 4 , d ‐Phe 7 ]‐α‐MSH 4–10 ‐NH 2 (0.02) · Ac‐[ d ‐Phe 7 ]‐α‐MSH 5–11 ‐NH 2 (0.01) &gt; Ac‐[Nle 4 ]‐α‐MSH 4–10 ‐NH 2 (0.002) = Ac‐[Nle 4 ]‐α‐MSH 4–11 ‐NH 2 &gt; Ac‐α‐MSH 4–10 ‐NH 2 (0.0003) · Ac‐α‐MSH 5–11 ‐NH 2 (0.0002). On the other hand the relative potencies on the lizard ( Anolis carolinensis ) skin system were found to be: Ac‐[Nle 4 , d ‐Phe 7 ]‐α‐MSH 4–10 ‐NH 2 (10) · Ac‐[Nle 4 , d ‐Phe 7 ]‐α‐MSH 4–11 ‐NH 2 (8.0) · Ac‐[Nle 4 , d ‐Phe 7 ]‐α‐MSH (5.0) &gt; α‐MSH (1.0) = Ac‐[Nle 4 ]‐α‐MSH 4–11 ‐NH 2 = Ac‐[ d ‐Phe 7 ]‐α‐MSH 5–11 ‐NH 2 &gt; Ac‐[Nle 4 ]‐α‐MSH 4–10 ‐NH 2 (0.06) &gt; Ac‐α‐MSH 5–11 ‐NH 2 (0.01) &gt; Ac‐α‐MSH 4–10 ‐NH 2 (0.004). Detailed analyses of these data suggest species‐dependent differences in the stereostructural relationships of the residues in the 4, 7, and 11 positions for melanotropic potency in vitro. Particularly noteworthy is the observation that the 4–11 fragment analogue Ac‐[Nle 4 ]‐α‐MSH 4–11 ‐NH 2 is equipotent to α‐MSH in the lizard assay system, suggesting that the 1–3, 12, and 13 residues of α‐MSH are not involved in the binding or transduction in this system. Examination of the ability of these α‐melanotropin analogues to effect sustained biological activity (prolongation) following removal of exogenous peptide from the bioassay medium showed striking differences in the two systems. On the lizard skin assay, only [Nle 4 , d ‐Phe 7 ]‐α‐MSH, Ac‐[Nle 4 , d ‐Phe 7 ]‐α‐MSH 4–11 ‐NH 2 and Ac‐[Nle 4 , d ‐Phe 7 ]‐α‐MSH 4–10 ‐NH 2 effect marked prolonged melanotropic activity as compared to α‐MSH. In contrast, on the frog skin assay, only [Nle 4 , d ‐Phe 7 ]‐α‐MSH, Ac‐[Nle 4 , d ‐Phe 7 ]‐α‐MSH 4–11 ‐NH 2 , Ac‐α‐MSH 5–11 ‐NH 2 , and Ac‐[Nle 4 ]‐α‐MSH 4–10 ‐NH 2 exhibited significant prolonged activity. These results demonstrate that relative potency and prolongation of melanotropic activity are not directly related, but rather are the manifestation of different, species‐dependent structural and topographical requirements for peptide‐receptor interactions related to binding and signal transduction.
A minimally invasive multiple marker approach allows highly efficient detection of meningioma tumors (2006)

Our approach offers the possibility to screen members of risk groups as a matter of routine such that tumors hopefully can be diagnosed immediately after their genesis. The early detection will finally result in a higher cure- and lower morbidity-rate.
Chromosomal integration vectors allowing flexible expression of foreign genes in Campylobacter jejuni (2015)

The plasmids constructed allow stable chromosomal expression of genes in C. jejuni and, depending on the promoter used, different expression levels were obtained making these plasmids useful tools for genetic complementation and high level expression.
Minimal cost stable workforce allocation in presence of ties (2016)

In this paper, we address the problem of allocating workforce to software projects, considering bilateral (project managers' and employees') preferences and cost of allocation. Earlier research has addressed the workforce allocation to software projects as stable matching problem with strict preferences ranking. However, in practice, there are scenarios where project managers did not strictly rank the employees; therefore, there are ties in the preference list. We developed a stable matching with ties-based optimization model to create a minimum cost stable allocation. Our results suggest that a software firm can reduce allocation cost and improve the average preferences for both the workforce and the project managers in the presence of ties in the preference list.
Mechanistic Study of Thermoreversible Recording Media Composed of Polymeric Films with Dispersed Fatty Acids (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanistic Study of Thermoreversible Recording Media Composed of Polymeric Films with Dispersed Fatty AcidsYoshihiko Hotta, Tsuguo Yamaoka, Kunichika Morohoshi, Tetsuya Amano, and Kyoji TsutsuiCite this: Chem. Mater. 1995, 7, 10, 1793–1799Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://pubs.acs.org/doi/10.1021/cm00058a007https://doi.org/10.1021/cm00058a007research-articleACS PublicationsRequest reuse permissionsArticle Views97Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Spatially‐localized correlation of dGEMRIC‐measured GAG distribution and mechanical stiffness in the human tibial plateau (2004)

The concentration of glycosaminoglycan (GAG) in articular cartilage is known to be an important determinant of tissue mechanical properties based on numerous studies relating bulk GAG and mechanical properties. To date limited information exists regarding the relationship between GAG and mechanical properties on a spatially-localized basis in intact samples of native tissue. This relation can now be explored by using delayed gadolinium-enhanced MRI of cartilage (dGEMRIC--a recently available non-destructive magnetic resonance imaging method for measuring glycosaminoglycan concentration) combined with non-destructive mechanical indentation testing. In this study, three tibial plateaus from patients undergoing total knee arthroplasty were imaged by dGEMRIC. At 33-44 test locations for each tibial plateau, the load response to focal indentation was measured as an index of cartilage stiffness. Overall, a high correlation was found between the dGEMRIC index (T(1Gd)) and local stiffness (Pearson correlation coefficients r = 0.90, 0.64, 0.81; p < 0.0001) when the GAG at each test location was averaged over a depth of tissue comparable to that affected by the indentation. When GAG was averaged over larger depths, the correlations were generally lower. In addition, the correlations improved when the central and peripheral (submeniscal) areas of the tibial plateau were analyzed separately, suggesting that a factor other than GAG concentration is also contributing to indentation stiffness. The results demonstrate the importance of MRI in yielding spatial localization of GAG concentration in the evaluation of cartilage mechanical properties when heterogeneous samples are involved and suggest the possibility that the evaluation of mechanical properties may be improved further by adding other MRI parameters sensitive to the collagen component of cartilage.
IEEE Access Special Section Editorial: High Mobility 5G LTE-V: Challenges and Solutions (2018)

The Internet of Vehicles, previously referred to as Vehicular Ad Hoc Networks (VANETs), will be a collection of mobile ad hoc networks for vehicular communications to improve driving safety and traffic efficiency. Major categories include vehicle-to-vehicle (V2V) communications and vehicle-to-infrastructure (V2I) communications. Collectively these (and future categories) can be termed V2X communications. These two categories entail a variety of communication channels, network topologies, vehicle densities and communication scenarios, and in response to this, IEEE has released the IEEE 802.11p and IEEE 1609 protocols for VANETs. With the global commercial application of Long Term Evolution (LTE) mobile communication systems, LTE based vehicular (LTE-V) networks have been shown to offer advantages in V2I communications, coverage, high mobility and complicated communication scenarios. Therefore, in the 5th generation’s (5G) mobile communication networks, the 3GPP is discussing V2V communications as a device-to-device (D2D) communication application. As is well known, in high mobility scenarios, the wireless channel is rapidly time- varying, Doppler shifts and spreads can be much larger than in cellular, network topology can change quickly, and switching among base stations and vehicles is more frequent. All this presents formidable challenges to realizing reliable communications with low latency in 5G LTE-V systems.
Electroless Deposition of Au Nanocrystals on Si(111) Surfaces as Catalysts for Epitaxial Growth of Si Nanowires (2006)

Au nanocrystals were prepared by reacting solutions containing with hydrogen-terminated silicon (111) surfaces. The nanocrystals catalyze the subsequent growth of silicon nanowires by chemical vapor deposition using a mixture of and in a ambient. Depositing the metal nanocrystals from nonaqueous solutions, such as ethanol, minimizes the oxidation of Si that can occur in an aqueous solution and allows epitaxially aligned growth of the nanowires. The Au nanocrystals preferentially deposit onto hydrogen-terminated compared to silicon dioxide. This selective deposition allows positioning of nanocrystals on patterns formed using either conventional lithography or nanoimprint lithography.
Systematic speed-power memory data-layout exploration for cache controlled embedded multimedia applications (2001)

The ever increasing gap between processor and memory speeds has motivated the design of embedded systems with deeper cache hierarchies. To avoid excessive miss rates, instead of using bigger cache memories and more complex cache controllers, program transformations have been proposed to reduce the amount of capacity and conflict misses. This is achieved however by complicating the memory index arithmetic code which results in performance degradation when executing the code on programmable processors with limited address capabilities. However, when these are complemented by high-level address code transformations, the overhead introduced can be largely eliminated at compile time. In this paper, the clear benefits of the combined approach is illustrated on two real-life applications of industrial relevance, using popular programmable processor architectures and showing important gains in energy (a factor 2 less) with a relatively small penalty in execution time (8-25%) instead of factors overhead without the address optimisation stage. The results of this paper leads to a systematic Pareto optimal trade-off (supported by tools) between memory power and CPU cycles which has up to now not been feasible for the targeted systems.The ever increasing gap between processor and memory speeds has motivated the design of embedded systems with deeper cache hierarchies. To avoid excessive miss rates, instead of using bigger cache memories and more complex cache controllers, program transformations have been proposed to reduce the amount of capacity and conflict misses. This is achieved however by complicating the memory index arithmetic code which results in performance degradation when executing the code on programmable processors with limited address capabilities. However, when these are complemented by high-level address code transformations, the overhead introduced can be largely eliminated at compile time. In this paper, the clear benefits of the combined approach is illustrated on two real-life applications of industrial relevance, using popular programmable processor architectures and showing important gains in energy (a factor 2 less) with a relatively small penalty in execution time (8-25%) instead of factors overhead without the address optimisation stage. The results of this paper leads to a systematic Pareto optimal trade-off (supported by tools) between memory power and CPU cycles which has up to now not been feasible for the targeted systems.
Session details: Volume I: Artificial intelligence and agents, distributed systems, and information systems: Smart human computer interaction track (2015)

No abstract available.