Extracorporeal Photochemotherapy for Drug-Resistant Pemphigus Vulgaris (1990)

Brief Reports15 February 1990Extracorporeal Photochemotherapy for Drug-Resistant Pemphigus VulgarisAlain H. Rook, MD, Brian V. Jegasothy, MD, Peter Heald, MD, George T. Nahass, MD, Chérie Ditre, MD, William K. Witmer, BS, Gerald S. Lazarus, MD, Richard L. Edelson, MDAlain H. Rook, MD, Brian V. Jegasothy, MD, Peter Heald, MD, George T. Nahass, MD, Chérie Ditre, MD, William K. Witmer, BS, Gerald S. Lazarus, MD, Richard L. Edelson, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-4-303 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe extracorporeal exposure of pathogenic peripheral blood leukocytes to the natural compound 8-methoxypsoralen (8-MOP) and ultraviolet A radiation has provided great benefit in certain advanced forms of cutaneous T-cell lymphoma (1). Extracorporeal photochemotherapy was given to four patients with persistent cases of the autoimmune blistering disease, pemphigus vulgaris, who had previously needed large doses of immunosuppressive drugs to control their disabling disease. Two representative cases are described in detail.Case ReportsPatient 1A 61-year-old man who had extensive blisters and erosions that had been resistant to many months of prednisone and azathioprine therapy had extracorporeal photochemotherapy initiated with treatments...References1. Edelson R, Berger C, and Gasparro F. Treatment of cutaneous T-cell lymphoma by extracorporeal photochemotherapy: preliminary results. N Engl J Med. 1987;316:297-303. CrossrefMedlineGoogle Scholar2. Korman N. Pemphigus. J Am Acad Dermatol. 1988;18:1219-38. CrossrefMedlineGoogle Scholar3. Perez M, Edelson R, Laroche L, and Berger C. Inhibition of antiskin allograft immunity by infusions with syngeneic photoinactivated effector lymphocytes. J Invest Dermatol. 1989;92:669-76. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Alain H. Rook, MD; Brian V. Jegasothy, MD; Peter Heald, MD; George T. Nahass, MD; Chérie Ditre, MD; William K. Witmer, BS; Gerald S. Lazarus, MD; Richard L. Edelson, MDFrom the Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; and Yale University School of Medicine, New Haven, Connecticut. For current author addresses, see end of text. 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