gebhart/patrepeval huggingface dataset:
Electrostrictive microelectromechanical fibres and textiles (2017)

Abstract Microelectromechanical systems (MEMS) enable many modern-day technologies, including actuators, motion sensors, drug delivery systems, projection displays, etc. Currently, MEMS fabrication techniques are primarily based on silicon micromachining processes, resulting in rigid and low aspect ratio structures. In this study, we report on the discovery of MEMS functionality in fibres, thereby opening a path towards flexible, high-aspect ratio, and textile MEMS. The method used for generating these MEMS fibres leverages a preform-to-fibre thermal drawing process, in which the MEMS architecture and materials are embedded into a preform and drawn into kilometers of microstructured multimaterial fibre devices. The fibre MEMS functionality is enabled by an electrostrictive P(VDF-TrFE-CFE) ferrorelaxor terpolymer layer running the entire length of the fibre. Several modes of operation are investigated, including thickness-mode actuation with over 8% strain at 25 MV m−1, bending-mode actuation due to asymmetric positioning of the electrostrictive layer, and resonant fibre vibration modes tunable under AC-driving conditions.
Severe osteopetrosis, defective interleukin‐1 signalling and lymph node organogenesis in TRAF6‐deficient mice (1999)

The results identify TRAF6 as an essential component of ODF signalling pathway, and also show that TRAF6 plays pivotal roles in immune and inflammatory systems in vivo.
Commentary: “Zooming in” on Glioblastoma: Understanding Tumor Heterogeneity and Its Clinical Implications in the Era of Single-Cell Ribonucleic Acid Sequencing (2021)

Lucas, Alfredo MSc; Eberwine, James H PhD; Bagley, Stephen J MD, MSCE; Fan, Yi MD, PhD; Nasrallah, MacLean P MD, PhD; Brem, Steven MD Author Information
Effect of Post-mold Curing on Package Reliability (2004)

Silica filled epoxy resins as encapsulation in chip packages reveal a major influence on the reliability and functionality of microelectronic devices. In this study, the resulting effects of postmold curing (PMC) on the thermomechanical and chemical properties of different mold compounds were observed. Polymer systems of the investigated mold compounds were based on two orthocresol novolacs (OCN), one biphenyl and one multifunctional resin (MFR). It could be shown, that longer thermal treatment after curing leads in general to further cross-linking of the polymer chains and increases the glass transition temperature T g . Therefore, the temperature resistance of the mold for following process steps after package assembling, like soldering, can be improved as well as the reliability during temperature cycle tests. However, PMC treatment also increases the moisture absorption. Here, MFR mold exhibit the highest moisture absorption. Also the high T g of the MFR mold is not much influenced by PMC. Hence, further thermal treatment after curing of the MFR mold is not necessary. In case of OCN and biphenyl mold types, the advantages of PMC are predominating.
Performance evaluation of an OpenPET detector for heavy Ion therapy under actual in-beam condition (2010)

OpenPET which consists of two detector rings separated axially is suitable for in-beam PET in heavy ion therapy. Although the primary ion beam do not enter into the PET detector in the OpenPET, light fragment ions from a target can enter into the detectors and could affect the detector performance under the actual in-beam condition. Previously, we demonstrated that the OpenPET detector can be sufficiently operated in off-beam experiments after carbon beam irradiation. In this presentation, we reported the results of in-beam measurements with a prototype OpenPET detector optimized for the in-beam measurement. Experiments were performed in the Heavy Ion Medical Accelerator in Chiba (HIMAC) at the National Institute of Radiological Sciences. The OpenPET detector consisted of a 8 × 8 × 4 LGSO crystal array and a 64-channel PS-PMT. The size of the crystals was 2.9mm × 2.9mm × 5.0mm. The energy and intensity of the <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</sup> C beam were 290MeV/u and 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8</sup> -10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">9</sup> particle per second (pps). This beam condition is similar to the actual treatment condition in HIMAC. Carbon ions entered to a water phantom and all of the primary carbon ions were stopped in the water. The OpenPET detector was positioned 30cm apart from the backside of the water phantom at an angle of 30 degree. A coincidence detector was positioned at the opposite side of the water phantom. As a result, the sufficient crystal identification performance was achieved with slight deterioration of the position histograms.
A Robust Broadcast System Under Time- Varying Channels Based on OTFS Modulation (2021)

This paper proposes a robust broadcast system under time-varying channels based on an orthogonal time frequency space (OTFS) modulation. The OTFS modulation can reduce an effect of inter-carrier interference (ICI), which results from a Doppler shift, by mapping modulation symbols to a two-dimensional delay-Doppler domain. Therefore, the OTFS modulation can obtain robust reception performance under very rapid time-varying channels compared to orthogonal frequency division multiplexing (OFDM). Furthermore, the OTFS modulation can be regarded as pre- and post-processing of the OFDM system, and therefore the OTFS modulation can be easily applied to the OFDM system. Using these advantages of the OTFS modulation, the proposed broadcast system can reliably transmit high-quality services under high mobility conditions. Simulation results show that the proposed broadcast system based on the OTFS modulation outperforms the conventional Advanced Television Systems Committee (ATSC) 3.0 system under high Doppler shift environments.
Erratum (1992)

S. Nawaz, R. D. Coker and S. J. Haswell, Analyst, 1992, 117, 828 DOI: 10.1039/AN9921700828
Improvement of accuracy of extraction of radiation patterns from FDTD modelling of axisymmetrical antennas (2011)

This paper presents a discussion on the accuracy of extraction of radiation patterns of BOR antennas from FDTD simulations. The effect of the "main beam shadow" causing errors in extracted back radiation was explained. The methods of its elimination were proposed.
Explosive flux compression generators at LLNL (2012)

At Lawrence Livermore National Laboratory we have developed a coupled helical-coaxial FCG device called the Full Function Test (FFT). This device was used to deliver 98 MA of current and 66 MJ of energy to an inductive load. The successful testing of the FFT represented the culmination of an effort to establish a high-energy pulsed power program that would greatly exceed the performance of capacitor bank facilities. Using the modeling, design, and experimental capabilities developed for the FFT, we have developed a new generator, the Mini-G. Based upon a half-scaling of the FFT device, the Mini-G is a coupled helical-coaxial FCG capable of delivering up to 60 MA of current and 8 MJ of energy. We will describe the design of this generator which involved the use of simulation codes as well as innovative pulsed power techniques to obtain a compact, optimized device.
Abstract 1621: Discovery of pyridyl pyrrolopyridinones as potent and selective CK1γ inhibitors (2014)

Abstract The canonical Wnt pathway regulates the ability of β-catenin to activate specific target genes. Aberrant activation of the Wnt pathway is believed to drive the development and growth of many cancers; for example, APC mutations were observed in &amp;gt;80% of the sporadic colorectal cancers. The casein kinase 1 (CK1) family of serine/threonine protein kinases is highly conserved. Multiple members of the CK1 family are shown to regulate the Wnt pathway through interactions with various proteins. The central role of CK1γ in Wnt signal transduction makes it an attractive target for the treatment of Wnt-pathway dependent cancers. We employed a structure-based approach and identified a series of pyridyl pyrrolopyridinones as potent and selective CK1γ inhibitors. These compounds exhibited good enzyme and cell potency, as well as selectivity against other CK1 isoforms, and favorable rodent PK profiles. Oral dosing of optimized lead compounds resulted in significant inhibition of LRP6 phosphorylation in a mouse tumor PD model. Citation Format: Hongbing Huang, Lisa Acquaviva, Howard Bregman, John Buchanan, Nagasree Chakka, Erin F. DiMauro, Jennifer Dovey, Hakan Gunaydin, Zihao Hua, Xin Huang, Liyue Huang, Vinod F. Patel, Matthew W. Martin, Randy Serafino, Cindy Wilson. Discovery of pyridyl pyrrolopyridinones as potent and selective CK1γ inhibitors. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1621. doi:10.1158/1538-7445.AM2014-1621
Warm-white-light emitting diode utilizing a single-phase full-color Ba3MgSi2O8:Eu2+, Mn2+ phosphor (2004)

The Ba3MgSi2O8:Eu2+, Mn2+ shows three emission colors: 442, 505, and 620 nm. The 442 and 505 nm emission originate from Eu2+ ions, while the 620 nm emission originates from Mn2+ ions. The excitation bands of three emission colors are positioned around 375 nm. Electron paramagnetic resonance measurement demonstrates that Eu2+ ions are occupied with three different Ba2+ sites. The red emission of Mn2+ ions has a long decay time of 750 ms due to persistent energy transfer from oxygen vacancies to Mn2+ ions, while the blue and green bands of Eu2+ ions have decay times of 0.32 and 0.64 μs, respectively. The fabricated white-light emitting diode using a 400-nm-emissive chip with a white-light emitting Ba3MgSi2O8:Eu2+, Mn2+ phosphor shows warm white light and higher color stability against input power in comparison with a commercial GaN-pumped (Y1−xGdx)3(Al1−yGay)5O12:Ce3+ phosphor.
LATERAL CAPILLARY FORCES AND TWO-DIMENSIONA ARRAYS OF COLLOID PARTICLES AND PROTEIN MOLECULES (1997)

Abstract This paper presents a review of our recent studies on the lateral capillary forces and on their role in the formation of two-dimensional ordered arrays of colloidal particles or protein molecules. To reveal the mechanism of protein ordering in liquid films we carried out model experiments with micrometer sized latex particles. The films were formed on solid or liquid substrates. By variation of the electrolyte concentration, the particle charge and volume fraction we proved that neither the double layer repulsion, nor the van der Waals attraction between the particles, was responsible for the formation of the two-dimensional arrays. Direct microscope observations revealed that the process of ordering was triggered by attractive lateral capillary forces due to the overlap of the menisci formed around the particles. Two types of lateral capillary forces, flotation and immersion, could be distinguished and theory of these interactions was developed. The lateral capillary forces between a floating particle and a wall were also studied; they could be employed for precise determination of the shear surface viscosity.
Strategic computing at DARPA: overview and assessment (1985)

Strategic Computing, a 10-year initiative to build faster and more intelligent systems, is ambitious, flawed by overscheduling perhaps and problems of definition, but basically sound.
Living with respiratory viruses: The next saga in human/viral coexistence? (2021)

Testing for respiratory viruses and SARS-CoV-2 in clinical and epidemiological settings has contrasting purposes and utility. Symptomatic patients are best tested with respiratory virus panels to establish the pathogen and guide personalized treatment. Asymptomatic patients are tested for a single infectious pathogen to establish carrier status and guide containment.
Growth and characterization of fiber-shaped Raman crystals (2003)

Summary form only given. Solid-state Raman crystals are presently being investigated. Since they contain Raman active centers with intrinsically high concentrations, the stimulated Raman scattering (SRS) process offers lower thresholds and higher gain coefficients than gaseous media. To develop these advantages, we attempted to grow a Raman crystal by using the micro pull-down method. Using this technique, high-quality, fiber-shaped crystals with an optical waveguide effect were readily obtained without fabrication. We chose lanthanum tungstate La/sub 2/(WO/sub 4/)/sub 3/ (LWO). Though this compound has not been reported as a Raman material, it is expected to show strong SRS by symmetric vibration of W-O bonding.
Supplementary Figure 4 from Histone Deacetylases Are Required for Androgen Receptor Function in Hormone-Sensitive and Castrate-Resistant Prostate Cancer (2023)

Supplementary Figure 4 from Histone Deacetylases Are Required for Androgen Receptor Function in Hormone-Sensitive and Castrate-Resistant Prostate Cancer
POSTER: Automatic Parallelization Targeting Asynchronous Task-Based Runtimes (2019)

In a post-Moore world, asynchronous task-based parallelism has become a popular paradigm for parallel programming. Auto-parallelizing compilers are also an active area of research, promising improved developer productivity and application performance. This work seeks to unify these efforts by delivering an end-to-end path for auto-parallelization through a generic runtime layer for asynchronous task-based systems. First, we extend R-Stream, an auto-parallelizing polyhedral compiler, to express task-based parallelism and data management for a broader class of task-based runtimes. We additionally introduce a generic runtime layer for asynchronous task-based parallelism, which provides an abstract target for the compiler backend. We implement this generic runtime layer using OpenMP for shared memory systems and Legion for distributed memory systems. Starting from sequential source, we obtain geometric mean speedups of 23.0x (OpenMP) and 9.5x (Legion) on a wide range of applications, from deep learning to scientific kernels.
Contour lithography methods for DRIE fabrication of nanometre–millimetre-scale coexisting microsystems (2006)

This paper proposes a nanometrically precise fabrication method for nanometric and millimetric structures on the same wafer. The advancement in deep reactive ion etching (DRIE) is enabling a number of applications of high aspect ratio nanostructures. However, DRIE conditions optimized for nano-size openings are often incompatible with large area etching due to the aspect-ratio dependence of optimum conditions. This paper proposes to solve the problem by a two-step etching method: the etching of nanostructures plus contours of large area openings followed by the etching of the rest. Both masking layers for nano+contour and the rest of the area are embedded prior to the first deep etching. This 'embedded masking method' ensures fine lithography on the flat surface. The second masking for the rest of the area is created by LOCOS. Following LOCOS the process created a uniform passivation to large area etching. Its capability has been shown by successful fabrication of 1.3 µm wide optical filters coexisting with millimetre-scale (0.15 mm × 2.7 mm) trenches.
A probabilistic approach for the evaluation of minimal residual disease by multiparameter flow cytometry in leukemic B‐cell chronic lymphoproliferative disorders (2008)

Multiparameter flow cytometry has become an essential tool for monitoring response to therapy in hematological malignancies, including B-cell chronic lymphoproliferative disorders (B-CLPD). However, depending on the expertise of the operator minimal residual disease (MRD) can be misidentified, given that data analysis is based on the definition of expert-based bidimensional plots, where an operator selects the subpopulations of interest. Here, we propose and evaluate a probabilistic approach based on pattern classification tools and the Bayes theorem, for automated analysis of flow cytometry data from a group of 50 B-CLPD versus normal peripheral blood B-cells under MRD conditions, with the aim of reducing operator-associated subjectivity. The proposed approach provided a tool for MRD detection in B-CLPD by flow cytometry with a sensitivity of < or =8 x 10(-5) (median of < or =2 x 10(-7)). Furthermore, in 86% of B-CLPD cases tested, no events corresponding to normal B-cells were wrongly identified as belonging to the neoplastic B-cell population at a level of < or =10(-7). Thus, this approach based on the search for minimal numbers of neoplastic B-cells similar to those detected at diagnosis could potentially be applied with both a high sensitivity and specificity to investigate for the presence of MRD in virtually all B-CLPD. Further studies evaluating its efficiency in larger series of patients, where reactive conditions and non-neoplastic disorders are also included, are required to confirm these results.
InGaAsP/InP Geiger-mode APD-based LiDAR (2018)

During the past decade, significant advancement has been made on InGaAsP/InP Geiger-mode APDs (GmAPDs) through improvements of material growth, device design and operating circuitry. With the increase in device performance and the growing maturity of device fabrication technology, high performance, large format InGaAsP/InP GmAPD arrays have been successfully designed and manufactured. These arrays have single photon sensitivity in the short wavelength infrared (SWIR) spectral band and can provide 3-D imagery. InGaAsP/InP GmAPD arrays provide an enabling technology for many active optical applications, such as 3-D light detection and ranging (LiDAR) and other photon-starved applications where single photon sensitivity in the SWIR band is critical. InGaAsP/InP-based Geigermode LiDAR has been extensively used on airborne platforms. By using optical wavelengths along with sub-ns laser pulse widths, 3-D Geiger-mode LiDAR techniques provide centimeter-scale range resolution over extremely long distances on the order of tens of kilometers. Through the use of high-performance single photon detectors, Geiger-mode LiDAR systems achieve an order of magnitude improvement in mapping rate over other competing LiDAR technologies. A more recent exciting application of InGaAsP/InP GmAPD-based LiDAR is to enable advanced driver assistance systems (ADAS) and vehicle autonomy on automotive platforms. The single-photon sensitivity of GmAPDs and greater eye-safety of diode lasers at wavelengths beyond 1400 nm provide disruptive automotive LiDAR performance that will be essential to future autonomous vehicle navigation. Single photon sensitivity and simple pixel circuit operation enable the reduction in overall system SWaP, while the scalability of these semiconductor devices enables dramatic reduction in LiDAR cost.
Correction to Fragment-Linking Approach Using 19F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase (2017)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Fragment-Linking Approach Using 19F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-SecretaseJohn B. Jordan*, Douglas A. Whittington, Michael D. Bartberger, E. Allen Sickmier, Kui Chen, Ryan D. White, Yuan Cheng, and Ted JuddCite this: J. Med. Chem. 2017, 60, 7, 3218Publication Date (Web):March 28, 2017Publication History Published online28 March 2017Published inissue 13 April 2017https://pubs.acs.org/doi/10.1021/acs.jmedchem.7b00411https://doi.org/10.1021/acs.jmedchem.7b00411correctionACS PublicationsCopyright © 2017 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views650Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (137 KB) Get e-Alertsclose Get e-Alerts
ChemInform Abstract: SYNTHESES OF TRIARYLBUTANES AND SUBSTITUTED DIARYL ALKANONES (1981)

Abstract Die Triarylbutadiene (I) werden mit Palladium/Kohle zu den Triarylbutanen (II) hydriert.
Large-scale fault isolation in the internet (2001)

In the Internet network dynamics such as congestion and route changes can cause lost or delayed transmissions. Such faults can significantly affect application performance. Diagnosis of these faults within the network is difficult. The goal of this dissertation is to design and evaluate techniques that enable the diagnosis of application perceived faults. Our approach is based on approximately isolating the location of application perceived faults and subsequently probing in the isolated fault area in order to diagnose the fault. Our techniques are based on (a) careful and adaptive end-system probing, and (b) obtaining different perspectives by probing from distributed locations. 
We successfully demonstrate our approach through the design and evaluation of distributed, probe based fault isolation techniques for IP multicast. Receivers in multicast sessions are instrumented with “multicast traceroute” to periodically collect loss statistics, delays and path information along the multicast distribution tree. The receivers co-ordinate with each other to share monitoring responsibilities and to isolate, perhaps approximately, faults affecting reception. We develop currently deployable as well as router assist based schemes. Router assist schemes are based on “Subcast” and “Directed Multicast”. We find that while only one deployable scheme based on “TTL-scoping” has somewhat acceptable behavior while the router assist based schemes have very desirable scaling characteristics in addition to fairly accurate fault isolation capability. A secondary focus of this dissertation is to design and evaluate techniques to collect topology information, an important component of fault diagnosis. While our probing techniques may help approximately isolate faults, topology information may be required to infer the exact cause of the fault. We designed and evaluated techniques to track the inter-domain topology of the Internet. These techniques, based on analyzing inter-domain routing information, obtained fairly accurate maps. We also developed distributed and self-configuring techniques to enable scalable extraction of router-level topologies annotated with information useful for fault diagnosis.