gebhart/patrepeval huggingface dataset:
Experimental Characterization of Adsorption and Transport Properties for Advanced Thermo-Adsorptive Batteries (2013)

Thermal energy storage has received significant interest for delivering both heating and cooling in electric vehicles, to minimize the use of the on-board electric batteries for heating, ventilation and air-conditioning (HVAC). An advanced thermoadsorptive battery (ATB) is currently being developed, to provide both heating and cooling for an electric vehicle. We present a detailed thermophysical and physicochemical characterization of adsorptive materials for the development of the ATB. We discuss the feasibility of using contemporary adsorptive materials, such as zeolite 13X, by carrying out a detailed experimental characterization. In this study, zeolite 13X is combined with aluminum hydroxide (Al(OH)3) as a binder to improve the thermal conductivity. We also investigate the effect of densification on the overall transport characteristics of the adsorbent-binder composite material. Accordingly, the effective thermal conductivity, surface area, adsorption capacity and surface chemistry were characterized using the laser flash technique, surface sorption analyzer, thermogravimetric analyzer, and x-ray scattering technique. Thermal conductivity predictions of both zeolite 13X and its combination with the binder were made with existing conductivity models. Thermal conductivity in excess of 0.4 W/mK was achieved with the addition of 6.4 wt.% of Al(OH)3. However, a 10.6 % decrease in adsorption capacity was also observed. The experimental characterization presented herein is an essential step towards the development of the proposed ATB for next-generation electric vehicles. Topics: Experimental characterization
A Phenylalanine to Serine Substitution within an O-Protein Mannosyltransferase Led to Strong Resistance to PMT-Inhibitors in Pichia pastoris (2013)

Protein O-mannosyltransferases (PMTs) catalyze the initial reaction of protein O-mannosylation by transferring the first mannose unit onto serine and threonine residues of a nascent polypeptide being synthesized in the endoplasmic reticulum (ER). The PMTs are well conserved in eukaryotic organisms, and in vivo defects of these enzymes result in cell death in yeast and congenital diseases in humans. A group of rhodanine-3-acetic acid derivatives (PMTi) specifically inhibits PMT activity both in vitro and in vivo. As such, these chemical compounds have been effectively used to minimize the extent of O-mannosylation on heterologously produced proteins from different yeast expression hosts. However, very little is known about how these PMT-inhibitors interact with the PMT enzyme, or what structural features of the PMTs are required for inhibitor-protein interactions. To better understand the inhibitor-enzyme interactions, and to gain potential insights for developing more effective PMT-inhibitors, we isolated PMTi-resistant mutants in Pichia pastoris. In this study, we report the identification and characterization of a point mutation within the PpPMT2 gene. We demonstrate that this F664S point mutation resulted in a near complete loss of PMTi sensitivity, both in terms of growth-inhibition and reduction in O-mannosylglycan site occupancy. Our results provide genetic evidence demonstrating that the F664 residue plays a critical role in mediating the inhibitory effects of these PMTi compounds. Our data also indicate that the main target of these PMT-inhibitors in P. pastoris is Pmt2p, and that the F664 residue most likely interacts directly with the PMTi-compounds.
Zusammenfassung und Ausblick (2004)

Das IKT-basierte Kundenbeziehungsmanagement, oft auch als Cus tomer Relationship Management (CRM) bezeichnet, basiert auf der Grundannahme, dass Unternehmen durch das systematische Management ihrer Kundenbeziehungen einen ökonomischen Vorteil generieren können. Allerdings hat bisher das Fehlen von klar definierten und messbaren Nutzenpotentialen bzw. eines systematischen Ansatzes zur Evaluation des Nutzens bzw. Erfolgs des IKT-basierten Kundenbeziehungsmanagements eine objektive Beurteilung der erzielten ökonomischen Auswirkungen verhindert. Bei der Erfolgsmessung ergeben sich vor allem zwei Problemfelder. Die erste Schwierigkeit ergibt sich aufgrund der Tatsache, dass CRM-Systeme sich an der Schnittstelle zwischen Unternehmen und ihren Kunden befinden. Daraus folgt, dass der Erfolg bzw. die Qualität dieser Systeme sowohl vom Unternehmen als auch von seinen Kunden wahrgenommen wird und entsprechend auch aus diesen beiden Perspektiven beurteilt werden muss. Die großen Anzahl an schwer quantifizierbaren Erfolgsgrößen, so genannte intangible Assets, wie z.B. Kundenbindung, Servicequalität oder Vertrauen, stellt das zweite große Hindernis bei der Erhebung der Auswirkungen dar.
An Algorithm for Approximating Convex Pareto Surfaces Based on Dual Techniques (2012)

We consider the problem of approximating Pareto surfaces of convex multicriteria optimization problems by a discrete set of points and their convex combinations. Finding the scalarization parameters that optimally limit the approximation error when generating a single Pareto optimal solution is a nonconvex optimization problem. This problem can be solved by enumerative techniques but at a cost that increases exponentially with the number of objectives. We present an algorithm for solving the Pareto surface approximation problem that is practical with 10 or less conflicting objectives, motivated by an application to radiation therapy optimization. Our enumerative scheme is, in a sense, dual to a family of previous algorithms. The proposed technique retains the quality of the best previous algorithm in this class while solving fewer subproblems. A further improvement is provided by a procedure for discarding subproblems based on reusing information from previous solves. The combined effect of the enhancements is empirically demonstrated to reduce the computational expense of solving the Pareto surface approximation problem by orders of magnitude. For problems where the objectives have positive curvature, an improved bound on the approximation error is demonstrated using transformations of the initial objectives with strictly increasing and concave functions.
Optimized Germanium co-implant with B2H6 PLAD for better advanced PMOS device performance (2011)

The following abstracts are given: Optimized Germanium Co-Implant with B2H6 PLAD for Better Advanced PMOS Device Performance; Design of low noise CMOS charge pump with adjustable output voltage and adjustable power; Measurement and Simulation of Various Geometries of LTCC Electron Hop Funnels; Efficient Design and Synthesis of Decimation Filters for Wideband Delta-Sigma ADCs; A Novel Material Solution for Non Volatile Contact Bridge Memristive Memory Fabrication; Radiation induced effects in pure and Ag doped Ge-Se films; and Design Techniques for a 70 Gbps CMOS Multiplexer.
The Treatment of Patients with Symptomatic Common Bile Duct Stenosis Secondary to Chronic Pancreatitis Using Partially Covered Metal Stents: A Pilot Study (2005)

While partially covered metal stenting is safe and effective for the initial treatment of chronic pancreatitis-associated common bile duct stenosis and shows promising short-term results, long-term data show that dysfunction occurs in 50 % of cases. In light of the continued interest in nonsurgical treatment of this condition, further research is warranted to investigate new stent designs with improved long-term patency.
A Blind Time-Reversal Detector in the Presence of Channel Correlation (2013)

A blind target detector using the time reversal transmission is proposed in the presence of channel correlation. We calculate the exact moments of the test statistics involved. The derived moments are used to construct an accurate approximative Likelihood Ratio Test (LRT) based on multivariate Edgeworth expansion. Performance gain over an existing detector is observed in scenarios with channel correlation and relatively strong target signal.
Povidone-Iodine Wound Lavage to Prevent Infection After Revision Total Hip and Knee Arthroplasty (2019)

Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
The 6G Architecture Landscape - European perspective (2023)

This white paper summarizes the main findings from the European research landscape on the vision of the 6G architecture. Such a design vision is derived from around 45 projects starting from October 2020 in all relevant areas of 5G while paving the way towards 6G, within the 5G Public Private-Partnership (5G PPP) in the scope of the European Framework for Research and Innovation (the list of contributing projects can be obtained from the 5G PPP website at https://5g-ppp.eu/5g-ppp-phase-3-projects/.). At present, the European networking research community has started a new program along with 33 projects on the Smart Networks and Service (SNS) programme that will focus on 5G advanced and 6G. The 5G/B5G Architecture Working Group (WG), as part of the 5G PPP Initiative, is identifying and capturing novel trends and key technological enablers for the realization of the 5G and 6G architecture. The main findings and results of the Architecture WG are now captured in this white paper, which presents a consolidated view from European perspective on the technical directions for the architecture design in the 6G era.<br> The white paper starts with an analysis of the societal, economic, regulatory and technological trends on the design and development of future 6G networks towards 2030 and beyond. Infused by emerging and disruptive digital technologies on the horizon, wireless networks are and will be the keystone for enabling a transformation of the global economy and the evolution of human society. The evolution journey will carry on in the years ahead, driving a large scale of adoption of 5G and 5G-Advanced use cases with significantly decreased deployment and operation costs, and enabling new and innovative use-case-driven solutions towards the 6G with higher economic and societal values.<br> To realize aforementioned trends, this white paper highlights the related research work and presents all the key elements and key architecture enablers and solutions of future 6G network design; a design that is deeply rooted in real needs and can profoundly benefit humanity in the mid-to-long term. Specifically, a high-level view of the 6G End-to-End architecture as well as a functional view of the 6G reference architecture are introduced in this white paper, taking into consideration of new stakeholders in the mobile network ecosystem and how the architectural work is taking into account their requirements in all the domains of the network. The key architecture enablers, that will form the backbone of future 6G network architecture, includes all the related technological solutions for building intelligent, flexible, sustainable, secure, programmable networks and enabling versatile radio technologies, localization and sensing in the 6G networks.
AT1R dysregulation is crucial in the hypertension of human GRK4γ A142V transgenic mice (2009)

The renin‐angiotensin system (RAS), via the AT1 receptor (AT1R), plays a critical role in the control of blood pressure (BP) by regulating peripheral resistance and sodium balance. Dopamine, via several dopamine receptor subtypes (e.g., D1R), counter regulates the RAS, including the AT1R. Recent studies have revealed an important role of G protein‐coupled receptor kinases (GRKs) in BP control by regulating several G protein‐coupled receptors, including the AT1R and D1R. Polymorphisms of GRK subtype 4 (GRK4), by themselves or via their interaction with genes regulating the RAS, are associated with essential hypertension. We now report that human GKR4γ A142V transgenic mice (A142V‐Tg) relative to hGRK4γ wild‐type transgenic mice (WT‐Tg) are hypertensive and have increased expression of AT1R, associated with increased AT1R promoter activity. A142V‐Tg mice have increased BP response to angiotensin II infusion and AT1R blockade. Moreover, A142V‐Tg mice that are deficient of AT1R have normal BP. This is the first report showing a molecular mechanism for the regulation of the AT1R gene that affects BP control. The GRK4 gene by regulating several genes involved in BP control may explain the "apparent" polygenic nature of essential hypertension.
Investigation of dc Josephson current distribution in double-barrier three-terminal devices with a thin middle superconducting layer (1996)

Nb/Al–AlOx–Nb/Al–AlOx–Nb double-barrier three-terminal Josephson devices with a thin middle Nb/Al bilayer, which have potential for use as switching and amplifying elements in superconducting electronics, have been investigated in the stationary state by means of low-temperature scanning electron microscopy. For the devices with lateral sizes comparable with the effective Josephson penetration depth, we observed nearly homogeneous current distribution over the region common to the top and bottom junctions when the devices were biased across both the barriers in the absence of an external magnetic field. When the two junctions are biased separately, the current is concentrated at the junction edges in accordance with the behavior characteristic of distributed junctions. In an applied magnetic field, the vortex structure is confined to the area shared by both junctions when the device is biased as a whole. The experiment gives an indication that in the stationary state the spatial phase difference distribution of the two junctions coincides in the shared region at least in some interval of the external magnetic field.
Isolation and characterization of hypertoxinogenic (htx) mutants of Escherichia coli KL320(pCG86) (1981)

The structural genes for heat-labile enterotoxin (LT) are present on plasmid pCG86. Escherichia coli KL320(pCG86), LT was found to be cell associated. LT was present as a soluble protein in sonic lysates of KL320(pCG86). Thirty-one mutants of KL320(pCG86) that produced increased amounts of extracellular LT were isolated. These hypertoxinogenic (htx) mutants were assigned to four phenotypically distinct classes based on the amounts of cell-associated and extracellular LT in early-stationary-phase cultures. Type 1 and type 2 htx mutants produced significantly increased amounts of cell-associated LT. Type 3 and type 4 htx mutants produced normal or decreased amounts of cell-associated LT was similar to that of the wild type. In the mutants of types 1, 3, and 4, the ratios of extracellular to cell-associated LT were higher than that of the wild type and were characteristic for each strain. Cell lysis or leakage of macromolecular cytoplasmic constituents appeared to be significant for release of LT by mutants of types 1, 3, and 4, because supernatants from cultures of these mutants also contained increased amounts of protein and of the cytoplasmic enzyme glucose 6-phosphate dehydrogenase. In all four representative htx mutants, the hypertoxinogenic phenotypes were dependent on chromosomal mutations. The resident pCG86 plasmids were eliminated from the htx mutants of types 2 and 3. After wild-type plasmid pCG86 was introduced into the cured strains by conjugation, their hypertoxinogenic phenotypes were restored. We conclude that chromosomal loci in E. coli KL320 are important in regulating expression of the LT structural genes of plasmid pCG86.
Coupled Spiral Interferometer Gyroscope (2014)

This paper reports a study of the sensitivity to an absolute rotation of an optical gyroscope in which the sensing element is a coupled spiral interferometer (CSPIN), which is a spiral waveguide with coupling between adjacent arms. The two physical sensing mechanisms that contribute to this sensitivity are discussed. Numerical simulations show that after optimization, a CSPIN gyroscope has the same maximum possible sensitivity as an optimized resonant waveguide optical gyroscope with the same radius and loss coefficient. This maximum sensitivity is independent of the number of arms, and it decreases as the reciprocal of the waveguide loss coefficient.
Signal Propagation on Single Phase Power Distribution Lines at Power Line Carrier Frequencies (1987)

Two sets of propagation measurements were made on a 20,847 foot unenergized power distribution line in the frequency range 0 to 50 kHz. The line was configured with and without distribution transformers. From the first set of measurements a voltage transfer function was calculated for this line. In the second set of measurements the line was energized with a 25 kHz signal and the voltage, current and impedance were measured along the line. Various propagation characteristics such as attenuation, characteristic impedance, velocity of propagation, and standing wave ratios were determined from these measurements.
Retinoid Antagonism of NF-IL6: Insight into the Mechanism of Antiproliferative Effects of Retinoids in Kaposi’s Sarcoma (1997)

All-trans-retinoic acid (RA) is active in the treatment of Kaposi's sarcoma (KS), and retinoids inhibit KS cell growth in vitro. To understand the mechanism of retinoid action in KS, we studied the expression of autocrine growth factors of KS cells after RA treatment. We demonstrate that RA and its synthetic analogs inhibit the proliferation of KS cells by inhibiting the mRNA and protein levels of interleukin-6 (IL-6), an autocrine growth factor for KS cells. We further demonstrate that nuclear retinoid receptors (RA receptors [RARs] and retinoid X receptors [RXRs]) inhibit IL-6 promoter action by antagonizing the enhancer action of NF-IL6, a basic domain leucine zipper transcription factor belonging to the family of CAAT enhancer binding proteins. Furthermore, RARs and RXRs do not bind in vitro to an NF-IL6 binding site. However, the secondary folded structure of the DNA binding domain of RAR and RXR is obligatory for inhibiting NF-IL6 activity. Thus, NF-IL6 is a potential therapeutic target for the treatment of KS. Finally, using receptor-selective synthetic retinoids, we demonstrate that NF-IL6 antagonism and transactivation are separable functions of RAR alpha, thus indicating that synthetic retinoids with properties of NF-IL6 antagonism but lacking transactivation capabilities can be synthesized. Such retinoids might increase therapeutic potential in KS.
Experimental validation of VHF antenna miniaturization using Magneto Dielectric Material (2021)

This paper describes the ability of antenna miniaturization using two different fabricated Magneto Dielectric Materials specifically designed for the VHF band. Those particular materials are used to load two electrically small antennas (ka $\lt0.5)$: a Monopolar Wire Plate Antenna (MWPA) and an Inverted-F Antenna (IFA) designed respectively around 130 MHz and 70 MHz for airborne systems application. A particular material loading strategy is used showing efficient miniaturization factors of 72&#x0025; for the MWPA structure and 20&#x0025; for the IFA. Experimentation carried out in large anechoic chamber confirms the miniaturized antenna performances.
Role of interferon-gamma release assays in the diagnosis of pulmonary tuberculosis in patients with advanced HIV infection (2010)

An ELISPOT-based IGRA detected a high prevalence of latent tuberculosis infection in a hospitalized population of tuberculosis suspects with advanced HIV/AIDS but had limited utility for diagnosis of active tuberculosis in a high prevalence setting. Further research is needed to identify stronger and more specific immune responses in patients with active tuberculosis.
Organic Matrix Derived from Host–Microbe Interplay Contributes to Pathological Renal Biomineralization (2023)

Matrix stones are a rare form of kidney stones. They feature a high percentage of hydrogel-like organic matter, and their formation is closely associated with urinary tract infections. Herein, comprehensive materials and biochemical approaches were taken to map the organic-inorganic interface and gather insights into the host-microbe interplay in pathological renal biomineralization. Surgically extracted soft and slimy matrix stones were examined using micro-X-ray computed tomography and various microspectroscopy techniques. Higher-mineral-density laminae were positive for calcium-bound Alizarin red. Lower-mineral-density laminae revealed periodic acid-Schiff-positive organic filamentous networks of varied thickness. These organic filamentous networks, which featured a high polysaccharide content, were enriched with zinc, carbon, and sulfur elements. Neutrophil extracellular traps (NETs) along with immune response-related proteins, including calprotectin, myeloperoxidase, CD63, and CD86, also were identified in the filamentous networks. Expressions of NETs and upregulation of polysaccharide-rich mucin secretion are proposed as a part of the host immune defense to "trap" pathogens. These host-microbe derived organic matrices can facilitate heterogeneous nucleation and precipitation of inorganic particulates, resulting in macroscale aggregates known as "matrix stones". These insights into the plausible aggregation of constituents through host-microbe interplay underscore the unique "double-edged sword" effect of the host immune response to pathogens and the resulting renal biominerals.
Direct integration of dense parallel optical interconnects on a first level package for high-end servers (2005)

The direct integration of dense 48-channel parallel multiwavelength optical transmitter and receiver subassemblies directly onto a first level package using a flex lead attach has been demonstrated. Such an approach, at 10 Gb/s/channel would provide a linear edge bandwidth density of 300 Gb/s/cm. By attaching dense multichannel optical subassemblies directly onto an MCM, the performance limitations of the connectors and node card wiring can be avoided and the total bandwidth off the MCM can be increased while also enabling longer distance and higher speed signaling. This approach involves only a modest modification to the bent-flex approach commonly used for parallel optical modules intended for board mounting but enables a significant density and performance improvement for this application.
Double-Tip Artifact Removal From Atomic Force Microscopy Images (2016)

The Atomic Force Microscope (AFM) allows the measurement of interactions at interfaces with nanoscale resolution. Imperfections in the shape of the tip often lead to the presence of imaging artefacts such as the blurring and repetition of objects within images. Generally, these artefacts can only be avoided by discarding data and replacing the probe. Under certain circumstances (e.g., rare, high value samples, or extensive chemical/physical tip modification) such an approach is not feasible. Here, we apply a novel deblurring technique, using a Bayesian framework, to yield a reliable estimation of the real surface topography without any prior knowledge of the tip geometry (blind reconstruction). A key contribution is to leverage the significant recently successful body of work in natural image deblurring to solve this problem. We focus specifically on the 'double-tip' effect, where two asperities 1 are present on the tip, each contributing to the image formation mechanism. Finally, we demonstrate that the proposed technique successfully removes the 'double-tip' effect from high resolution AFM images which demonstrate this artefact whilst preserving feature resolution.