gebhart/patrepeval huggingface dataset:
Modeling and Control of a Multiport Converter based EV Charging Station with PV and Battery (2019)

As an environmental friendly vehicle, the increasing number of electrical vehicles (EVs) leads to a pressing need of widely distributed charging stations, especially due to the limited on-board battery capacity. However, fast charging stations, especially super-fast charging stations may stress power grid with potential overload at peaking time, sudden power gap and voltage sag. This paper discusses the detailed modeling of a multiport converter based EV charging station integrated with PV power generation, and battery energy storage system, by using ANSYS TwinBuilder. In this paper, the control scheme and combination of PV power generation, EV charging station, and battery energy storage (BES) provides improved stabilization including power gap balancing, peak shaving and valley filling, and voltage sag compensation. As a result, the influence on power grid is reduced due to the matching between daily charging demand and adequate daytime PV generation. Simulation results are presented to confirm the benefits at different modes of this proposed multiport EV charging circuits with the PV-BES configuration. Furthermore, SiC devices are employed to the EV charging station to further improve the efficiency. For different modes and functions, power losses and efficiency are investigated and compared in simulation with conventional Si devices based charging circuits.
Effect of Dipole Interactions on Blocking Temperature and Relaxation Dynamics of Superparamagnetic Iron-Oxide (Fe3O4) Nanoparticle Systems (2023)

The effects of dipole interactions on magnetic nanoparticle magnetization and relaxation dynamics were investigated using five nanoparticle (NP) systems with different surfactants, carrier liquids, size distributions, inter-particle spacing, and NP confinement. Dipole interactions were found to play a crucial role in modifying the blocking temperature behavior of the superparamagnetic nanoparticles, where stronger interactions were found to increase the blocking temperatures. Consequently, the blocking temperature of a densely packed nanoparticle system with stronger dipolar interactions was found to be substantially higher than those of the discrete nanoparticle systems. The frequencies of the dominant relaxation mechanisms were determined by magnetic susceptibility measurements in the frequency range of 100 Hz-7 GHz. The loss mechanisms were identified in terms of Brownian relaxation (1 kHz-10 kHz) and gyromagnetic resonance of Fe<sub>3</sub>O<sub>4</sub> (~1.12 GHz). It was observed that the microwave absorption of the Fe<sub>3</sub>O<sub>4</sub> nanoparticles depend on the local environment surrounding the NPs, as well as the long-range dipole-dipole interactions. These significant findings will be profoundly important in magnetic hyperthermia medical therapeutics and energy applications.
ChemInform Abstract: Total Synthesis of the Muscarines. (1988)

Abstract The syntheses of muscarine (XIII) and allo‐muscarine (XIV) are described as outlined in the reaction scheme.
EGFR Tyrosine Kinase Domain Mutations Are Detected in Histologically Normal Respiratory Epithelium in Lung Cancer Patients (2005)

To determine whether EGFR tyrosine kinase domain mutations are early events in the pathogenesis of lung adenocarcinomas, we tested for the presence of EGFR mutations in histologically normal bronchial and bronchiolar epithelia from lung adenocarcinomas bearing the common EGFR mutations. DNA was extracted from microdissected tissue obtained from 21 tumors with known EGFR mutations, 16 tumors without mutation, and 90 sites of normal bronchial and bronchiolar epithelium from the same surgical specimens. With the use of PCR and direct DNA sequencing, EGFR mutations identical to the tumors were detected in the normal respiratory epithelium in 9 of 21 (43%) patients with EGFR mutant adenocarcinomas but none in patients without mutation in the tumors. The finding of mutations being more frequent in normal epithelium within tumor (43%) than in adjacent sites (24%) suggests a localized field effect phenomenon. Our findings indicate that mutation of the tyrosine kinase domain of EGFR is an early event in the pathogenesis of lung adenocarcinomas, and suggest EGFR mutations as an early detection marker and chemoprevention target.
48 Single Molecule Array Ultra-Sensitive Cytokine Assays in EDTA Plasma Are Robust and Clinically Feasible (2018)

Changes in local cytokine levels accompany immune-mediated anti-tumor responses. However, cytokine responses are challenging to measure systemically, outside the tumor microenvironment. The lack of sensitivity in the sub-pg/mL range with existing assays is an obstacle in developing peripheral blood-based biomarkers for the field of immuno-oncology. The objective of this study was to clinically validate a new ultra-sensitive immunoassay platform with EDTA plasma patient specimens for eventual translation as a blood-based biomarker in immuno-oncology. Here, we describe the validation of ultra-sensitive single molecule array (Simoa) assays for IL-2, IL-6, IL-10, and IFNγ. Simoa cytokine assays have been carried out using serum but no studies have been carried out using plasma, which is more readily processed and prevents platelet activation, which can alter cytokine levels ex vivo. Ninety patient EDTA plasma specimens were obtained from excess CBC material. A subset of patient samples used was expected to be enriched for high endogenous cytokine levels by selecting for patients with high CRP levels. Up to 2.5 mL of whole blood was centrifuged at 2,000 x g for 15 minutes, and the supernatant plasma was then aliquoted and stored at –80°C. Either 29 uL (IL-6, IL-10) or 42 µl (IL-2, IFNγ) of thawed plasma was used for each Simoa assay. Simoa assays were performed using antibody pairs to form enzyme-labeled immunocomplexes on beads and were detected using single molecule counting with the HD-2 Analyzer (Quanterix, Lexington, MA). We evaluated various analytical parameters (linearity, precision, accuracy, lower limit of quantification, cross-reactivity, interferences) of the assay and assessed analyte stability to optimize for eventual clinical implementation. The Simoa assays for IL-2, IL-6, IL-10, and IFNγ were both linear and precise. The lower limit of quantitation was 0.01 pg/mL for IL-6 and IL-10, and 0.04 pg/mL for IL-2 and IFNγ. None of the four cytokine assays cross-reacted with up to 1,000 pg/mL recombinant protein. All analytes were stable in EDTA plasma at room temperature for up to six hours with the exception of IL-6; levels decreased by approximately 10% at six hours. There was no interference from hemolysis, icterus, and lipemia. Vigorous handling of whole blood specimens and transport by pneumatic tube did not significantly affect analyte levels. IL-2, IL-6, IL-10, and IFNγ are largely stable in EDTA plasma at room temperature for up to four hours after blood draw. Lower limits of quantitation by Simoa surpass those reported for ELISAs by an average of 722-fold for the four analytes measured. Simoa immunoassays are a robust technique to measure ultra-low concentrations of cytokines with high precision. Simoa cytokine immunoassays represent a promising approach for monitoring anti-tumor immune responses in peripheral blood.
Biocompatibility and tissue integration of a novel shape memory surgical mesh for ventral hernia: In vivo animal studies (2013)

Approximately 400,000 ventral hernia repair surgeries are performed each year in the United States. Many of these procedures are performed using laparoscopic minimally invasive techniques and employ the use of surgical mesh. The use of surgical mesh has been shown to reduce recurrence rates compared to standard suture repairs. The placement of surgical mesh in a ventral hernia repair procedure can be challenging, and may even complicate the procedure. Others have attempted to provide commercial solutions to the problems of mesh placement, but these have not been well accepted by the clinical community. In this article, two versions of shape memory polymer (SMP)-modified surgical mesh, and unmodified surgical mesh, were compared by performing laparoscopic manipulation in an acute porcine model. Also, SMP-integrated polyester surgical meshes were implanted in four rats for 30-33 days to evaluate chronic biocompatibility and capacity for tissue integration. Porcine results show that the modified mesh provides a controlled, temperature-activated, automated deployment when compared to an unmodified mesh. In rats, results indicate that implanted SMP-modified meshes exhibit exceptional biocompatibility and excellent integration with surrounding tissue with no noticeable differences from the unmodified counterpart. This article provides further evidence that an SMP-modified surgical mesh promises reduction in surgical placement time and that such a mesh is not substantially different from unmodified meshes in chronic biocompatibility.
3-amino thioacridone inhibits DNA synthesis and induce DNA damage in T-cell acute lymphoblastic leukemia (T-ALL) in a p16-dependent manner. (2004)

In T-cell Acute Lymphocytic Leukemia (T-ALL), the inhibitors of cyclin-dependent kinases (CDK) 4 and 6, p16 and p15, are inactivated almost universally at the DNA, RNA and protein levels. This suggests that CDK-targeting may be an effective therapeutic approach for T-ALL and other cancers. In this study, we tested 3 inhibitors of CDK4, 3-aminothioacridone (3-ATA), thioacridone (TA), and oxindole, for their effects on DNA synthesis and viability in primary T-ALL. Each compound was an effective inhibitor, with overall IC(50)s in similar ranges. In colony formation assay, leukemic cells were approximately 10-fold more sensitive to 3-ATA than normal bone marrow cells. When sorted by G1 protein status of T-ALL, p16(+), p15(+) or pRb(-) samples were significantly less sensitive to 3-ATA and TA, but not to oxindole, than p16(-), p15(-) or pRb(+) samples. There was no relationship of sensitivity with ARF expression. Despite their in vitro function as inhibitors of CDK4, 3-ATA did not inhibit pRb phosphorylation or cause G1 arrest, but did cause DNA damage and result in the induction and phosphorylation of p53. We conclude that 3-ATA efficacy can be predicted by p16 status in T-ALL, but the mechanism of action may be distinct from their in vitro ability to regulate CDK4 kinase activity
Effects of salinity and alkaline concentration on the spontaneous imbibition behaviour and rock properties of some shale rocks (2016)

Waterflooding performance in naturally fractured reservoirs depends on spontaneous imbibition of brine into the rock matrix and expulsion of oil via the fracture face. This paper is to investigate water imbibition characteristics into different shale formations. Distilled water, 2% KCl brine, 30% KCl brine, and high pH alkaline solutions (pH 11.78-13) were examined to recover oil from different shale formations. During the spontaneous imbibition, the maximum oil recovery was 59% for Mancos using distilled water, 44% for Eagle Ford using 2 wt% NaOH in distilled water, 24% for Barnett using distilled water, and 4% for Marcellus using 2 wt% NaOH and 2 wt% KCl. The higher oil recoveries of Mancos samples were correlated with clay swelling in distilled water. More oil was recovered when Eagle Ford cores exposed to NaOH solutions due to favourable mineral dissolution. On the other hand, Barnett was partially damaged when exposed to higher alkaline solutions (2 wt% NaOH), and Marcellus did allow any fluid imbibition. Alkaline solutions were able to alter shale rock wettability to strongly water wet. The rock hardness of the samples was significantly affected by alkaline solutions, which resulted in 50-98% loss of its initial value.
Dynamic range of DFB semiconductor lasers (1998)

Summary form only given. For high-fidelity, narrowband applications such as radar and microcellular PCS, the important figure of merit is the spurious free dynamic range, which is determined by the largest input RF power for which the intermodulation distortion is below the system noise floor. Modeling the dynamic range of a directly modulated laser requires a high-frequency model of the signal distortion as well as a model for the intensity noise in the laser. This paper presents the first such theoretical analysis of dynamic range in a distributed feedback (DFB) laser. The model is used to analyze the performance of an experimental UHF link and to determine an optimized device design. Spatially distributed rate equations based on the Green's function method are used to model the nonlinear response and noise of an index-coupled DFB laser. The noise power spectra are determined by introducing the Langevin noise sources into the rate equations. In this way, closed-form expressions for the intermodulation distortion and noise floor can be obtained; this facilitates efficient numerical simulation of DFB performance.
Optimizing algal lipid production and its efficient conversion to biodiesel (2014)

We report here the successful combination of a two-step algal growth protocol, maximizing lipid yields with a single-step, and efficient extraction/transesterification procedure for the production of biodiesel. As a part of a global effort to find green renewable energy sources, our research focused on defining the optimal conditions for growing oil-rich microalgal biomass and its direct conversion to biodiesel. The influence of temperature, nutrient limitation and light intensity on biomass production was analyzed in three microalgal species: Chlorella sp., Isochrysis sp. and Phaeodactylum tricornutum. The temperature was found to dramatically affect the algal growth rates, reaching up to 2–3-fold higher rates on the “optimal combinations” than under initial conditions. The effects of temperature, light intensity and nutrient-deficient conditions on triglyceride levels in algal cells were measured by Nile red staining. In Chlorella sp. and P. tricornutum, the highest lipid content was obtained at 20ºC, under high and low light intensity, respectively, and in Isochrysis sp. at 25ºC and intermediate light intensity. A synergistic effect appeared only in Chlorella sp., where the lipid content reached 62% of the dry biomass. The three species were grown under the conditions we found optimal for oil yield. The dry biomass was converted directly into biodiesel without first extracting the lipid phase. The direct transesterification process was performed at 60°C using an SrO catalyst and MW radiation, yielding 99.5% conversion of lipids to biodiesel in 5 minutes.
Endothelial NADPH Oxidase as the Source of Oxidants in Lungs Exposed to Ischemia or High K + (1998)

We have previously demonstrated the generation of reactive oxygen species (ROS) in cultured bovine pulmonary artery endothelial cells (BPAECs) and in isolated perfused rat lungs exposed to high K+ and during global lung ischemia. The present study evaluates the NADPH oxidase pathway as a source of ROS in these models. ROS production, detected by oxidation of the fluorophore, dichlorodihydrofluorescein, increased 2.5-fold in BPAECs and 6-fold in rat or mouse lungs exposed to high (24 mmol/L) K+. ROS generation was markedly inhibited by diphenyliodonium, a flavoprotein inhibitor, and by the synthetic peptide PR-39, an inhibitor of NADPH oxidase assembly, whereas allopurinol had no effect. With ischemia (1 hour), ROS generation by rat and mouse lungs increased 7-fold; PR-39 showed concentration-dependent inhibition of ROS production, with 50% inhibition at 3 micromol/L PR-39. ROS production in lungs exposed to high K+ or ischemia was essentially abolished in mice with a "knockout" of gp91(phox), a membrane-localized cytochrome component of NADPH oxidase; increased ROS production by these lungs after anoxia/reoxygenation was similar to control. PR-39 also inhibited ischemia and the high K+-mediated increase in lung thiobarbituric acid reactive substance. Western blotting of BPAECs and immunocytochemistry of BPAECs and rat and mouse lungs showed the presence of p47phox, a cytoplasmic component of NADPH oxidase and the putative target for PR-39 inhibition. In situ fluorescence imaging in the intact lung demonstrated that the increased dichlorofluorescein fluorescence in these models of ROS generation was localized primarily to the pulmonary endothelium. These studies demonstrate that ROS production in lungs exposed to ischemia or high K+ results from assembly and activation of a membrane-associated NAPDH oxidase of the pulmonary endothelium.
+Three-step H2Se/Ar/H2S reaction of metal precursors for large area Cu(In,Ga)(Se,S)2 with uniform Ga distribution (2012)

A three-step H <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> Se/Ar/H <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> S reaction is used to process Cu-In-Ga metal precursors to form Cu(In,Ga)(Se,S) <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> films over 10 × 10 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> substrates. The 1 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">st</sup> selenization step gives fine microstructure with Ga accumulation near the Mo back contact, primarily in a Cu <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">9</inf> Ga <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</inf> phase. Significant grain growth with homogenous through-film Ga distribution is obtained by the 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> Ar annealing step. The 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rd</sup> sulfization step completes the reaction process and incorporates S near the Cu(In,Ga)Se <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> surface. The resulting films show good adhesion and yielded devices with η = 14.8% and V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">OC</inf> = 612 mV.
System-Level Characterization of Datacenter Applications (2015)

In recent years, a number of benchmark suites have been created for the ``Big Data'' domain, and a number of such applications fit the client-server paradigm. A large volume of recent literature in characterizing ``Big Data'' applications have largely focused on two extremes of the characterization spectrum. On one hand, multiple studies have focused on client-side performance. These involve fine-tuning server-side parameters for an application to get the best client-side performance. On the other extreme, characterization focuses on picking one set of client-side parameters and then reporting the server microarchitectural statistics under those assumptions. While the two ends of the spectrum present interesting results, this paper argues that they are not enough, and in some cases, undesirable, to drive system-wide architectural decisions in datacenter design.
ChemInform Abstract: SYNTHESIS OF 1‐DEOXY‐8‐UNSATURATED‐TETRAHYDROCANNABINOL. STRUCTURE‐ACTIVITY RELATION OF 8‐UNSATURATED TETRAHYDROCANNABINOLS (1976)

Abstract Aus dem Tetrahydrocannabinol (I) erhält man mit Chlordiäthylphosphat und Lithium/Ammoniak unter Eliminierung der aromatischen phenolischen Funktion das 1‐Desoxy‐Derivat (II) in 70% Ausbeute.
Detailed overview 510(k) cleared imaging devices from Regulatory Aspects of Optical Methods and Exogenous Targets for Cancer Detection (2023)

&lt;p&gt;Detailed overview of 510(k) cleared imaging devices by the FDA.&lt;/p&gt;
The Wearable Artificial Kidney: Is Peritoneal Dialysis the Solution? (2009)

The evolution of technology in hemodialysis has a new challenge in the development of miniaturization, transportability and wearability of devices applicable for renal replacement therapy. Although we are not there yet, a new series of papers have recently been published showing promising results on the application of a wearable artificial kidney. Some of them use extracorporeal blood cleansing as a method of blood purification while others use peritoneal dialysis as a treatment modality. Many of the challenges imposed by an extracorporeal wearable artificial kidney can be overcome by the use of the PD technique in a wearable system. A PD-based wearable artificial kidney has been demonstrated to be feasible and potentially applicable in chronic patients. We should make an effort to make a quantum leap in technology making the wearable artificial kidney a reality rather than a dream.
Enhanced nickel(II) chelation by gem-dimethyl-substituted macrocyclic tetrathioethers (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnhanced nickel(II) chelation by gem-dimethyl-substituted macrocyclic tetrathioethersJohn M. Desper, Samuel H. Gellman, Robert E. Wolf Jr., and Stephen R. CooperCite this: J. Am. Chem. Soc. 1991, 113, 23, 8663–8671Publication Date (Print):November 1, 1991Publication History Published online1 May 2002Published inissue 1 November 1991https://pubs.acs.org/doi/10.1021/ja00023a013https://doi.org/10.1021/ja00023a013research-articleACS PublicationsRequest reuse permissionsArticle Views266Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Détection de tumeurs de la prostate par fluorescence proche-infrarouge (2013)

National audience
TOWARDS SECURE NETWORK COMMUNICATIONS WITH CLIENTS HAVING CRYPTOGRAPHICALLY ATTESTABLE INTEGRITY (2013)

In a client-server communication, the server side must trust the client before releases confidential data or accepts commands received from the client. While industry best practices and considerable amount of research focus on secure credential authentication, we stress that this is at most a deceptive effort, providing only a false sense of security. We underline the sharp contradiction between state-of-the-art industry wide practices and the security that researchers campaign for, with special focus on online banking solutions. We present a brief review of a wide range of cyberattack techniques used today to perform large scale identity theft, financial fraud or espionage. We believe that current approaches, including inside-OS security solutions or relying only on credential authentication are outdated, and an industry wide shift is needed to provide trustable, integrity attested clients. Our solution is created around a type 1 bare-metal hypervisor, relying on hardware-enforced technologies to provide strong isolation between a secure operating environment on the clients and a possibly compromised OS. Blending an easily deployable solution with remote cryptographic identity attestation support, we believe that our proposal carries a significant value, both from security point of view and market applicability. In order to support a proper evaluation of the strength and weaknesses of the solution, we also present a comprehensive review of various remaining attack techniques and strategies.