gebhart/patrepeval huggingface dataset:
Kenneth G. Standing (April 3, 1925–March 21, 2019) (2020)

ADVERTISEMENT RETURN TO ISSUEPREVObituaryNEXTKenneth G. Standing (April 3, 1925–March 21, 2019)Werner Ens*Werner EnsDepartment of Physics and Astronomy, University of Manitoba, Winnipeg R3T 2N2, Canada*Email: [email protected]More by Werner Enshttp://orcid.org/0000-0002-8183-1193, Igor ChernushevichIgor ChernushevichSciex, Concord M2R3K7, Ontario, CanadaMore by Igor Chernushevich, and Alexander LobodaAlexander LobodaFluidigm Canada, Markham L3R 4G5, Ontario, CanadaMore by Alexander LobodaCite this: J. Am. Soc. Mass Spectrom. 2020, 31, 5, 1163–1165Publication Date (Web):May 6, 2020Publication History Received13 February 2020Accepted12 March 2020Revised5 March 2020Published online6 May 2020Published inissue 6 May 2020https://pubs.acs.org/doi/10.1021/jasms.0c00049https://doi.org/10.1021/jasms.0c00049obituaryACS PublicationsCopyright © 2020 American Society for Mass Spectrometry. Published by the American Chemical Society. All rights reserved. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views710Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (4 MB) Get e-AlertscloseSUBJECTS:Ions,Mass spectrometry,Peptides and proteins,Proteomics Get e-Alerts
A Discrete Five-Coordinated Cationic Aluminum Complex Supported by a Fluorinated Dialkoxy-Diimino Salen-like Ligand: Synthesis, Structure, and Use in Polymerization Catalysis (2010)

Methyl abstraction from a neutral aluminum complex stabilized by a salen-like fluorinated dialkoxide-diimino ligand yields the corresponding cationic species, which exists as a five-coordinate Et2O adduct in the solid state and in solution. This complex promotes the cationic polymerization of propylene oxide and p-methylstyrene at low temperatures.
Fine‐scale observations of spatio‐spectro‐temporal dynamics of bird vocalizations using robot audition techniques (2020)

Abstract Ecoacoustics needs sophisticated acoustic monitoring tools to extract a wide level of features from an observed mixture of sounds. We have developed a portable acoustic monitoring system called ‘HARKBird’ which consists of a laptop PC and an inexpensive commercial microphone array with the robot audition software HARK. HARKBird can extract acoustic events in a recording, and we can obtain the begin and end timings, the spatial information (e.g., position or direction from the microphone array), and the spectrogram of the sound separated from the original recording. In this study, we report how robot audition techniques contribute to monitoring spatio‐spectro‐temporal dynamics of bird behaviors, using an extended and minimal system based on multiple microphone arrays. The dimension reduction of separated sounds is important to integrate the information from multiple microphone arrays. As a dimension reduction algorithm, we use t‐SNE to help manual annotation of each sound and to generate the vocalization distribution automatically. We conduct playback experiments to Spotted Towhee ( Pipilo maculatus ) to simulate different cases of territorial intrusions (song/call/no playback). Our hypothesis in playback experiments is that playback of conspecific vocalizations would invoke aggressive responses of males against song playbacks and the effects would be more prominent than those of call playbacks. Our primary aim is to test whether our system can extract the necessary information on the aggressiveness of target individuals to examine our hypothesis. We show the system with manual annotation of vocalizations can extract their different spatio‐spectro‐temporal dynamics in different conditions, which supported our hypothesis. We also consider the spectral affinity‐based automatic matching of localized sounds from different microphone arrays. The relative number of localized songs depending on the playback conditions reflected a similar trend to those in the manual approach, implying that we can grasp the long‐term dynamics of vocalizations without costly annotations.
Choroidal Nevus in an Eye with Polypoidal Choroidal Vasculopathy (2014)

In cases of PCV, FAF images are helpful in determining the status of the posterior pole. Intravitreal injections of aflibercept can improve PED associated with CNV, and the BCVA will remain stable for at least 12 months.
Ultrahigh-resolution optical coherence tomography in the visible and 1300-nm wavelength region (2003)

Ultrahigh axial resolution OCT is demonstrated in human cells and other human biopsies for two fiber broadened femtosecond light sources, achieving 0.5&mu;m axial resolution in the visible and 1.4&mu;m in the in the 1300nm wavelength region.
A Simple Algorithm for Dual Frequency Ground Monitoring Compatible with ARAIM (2008)

Dual frequency Absolute RAIM has the potential of
providing global coverage of vertical guidance. However,
a constellation of thirty or more satellites will be
necessary to achieve this goal. In this work, a hedge for
Absolute RAIM users at a low cost for the integrity
provider is investigated. The concept relies on a simple
real time ground monitoring algorithm and on the
generalization of the ARAIM algorithms. The ground
monitoring described here consists of a simple snapshot
algorithm where all unknowns are estimated
simultaneously – although exploiting explicitly the
ARAIM assumptions. For each satellite, a bound on the
worst case error is broadcast. This error bound is
integrated by the user in the ARAIM solution. This is
achieved by generalizing the Multiple Hypothesis
Solution Separation ARAIM algorithm. Preliminary
performance results are shown for a reference station
network in North America as a function of the reference
network and the constellation. Finally, the importance of
the ARAIM assumptions and the necessity of offline
monitoring are stressed.
Microwave-assisted synthesis of iron sulfide motifs for electrochemical applications (2023)

Abstract The syntheses of FeS 2 and Fe 3 S 4 nanomaterials were optimized using a novel facile, surfactant-free, and microwave-assisted, one-pot synthesis method, run under ambient and reasonably mild reaction conditions. Synthetic parameters, such as metal precursor salt identity, reaction time, reaction temperature, metal:sulfur molar ratios, and solvent combinations, were all systematically investigated and optimized. A series of FeS 2 (pyrite) samples was initially fabricated using thioacetamide (TAA) as the sulfur precursor to generate a distinctive, uniform octahedra-based morphology. Switching the sulfur precursor from TAA to L-cysteine resulted in a corresponding transformation in not only chemical composition from FeS 2 to an iron thiospinel structure, Fe 3 S 4 (otherwise known as greigite), but also an associated morphological evolution from octahedra to nanosheet aggregates. The study of these materials has enabled crucial insights into the formation mechanisms of these materials under a relatively non-conventional microwave-assisted setting. Furthermore, in separate experiments, multi-walled carbon nanotubes (MWNTs) and graphene were added in with underlying metal sulfide species to create conductive Fe–S/MWNT composites and Fe–S/graphene composites, respectively. The method of addition of either MWNTs or graphene was also explored, wherein an ‘ ex-situ ’ synthetic procedure was found to be the least disruptive means of attachment and immobilization onto iron sulfide co-reagents as a means of preserving the latter’s inherent composition and morphology. The redox acidity for the parent material and associated composites demonstrates the utility of our as-developed synthetic methods for creating motifs relevant for electrochemical applications, such as energy storage.
EXAFS of Carbon Monoxide Oxidation on Supported Pt Fuel Cell Electrocatalysts (2000)

The potential dependence of the extended X-ray absorption fine structure (EXAFS) obtained at the Pt LIII absorption edge for a carbon supported Pt electrocatalyst exposed to carbon monoxide is presented. The data have been analyzed using the difference file method to separate the dominant contributions of the Pt neighbors from contributions to the EXAFS from the adsorbed species. The presence of adsorbed CO is clearly observed with a Pt−C distance of 1.85 Å at potentials less than 0.5 V vs RHE. Increasing the potential above 0.5 V resulted first in the removal of the adsorbed CO and at more positive potentials, e.g., 1.05 V, in the formation of an oxide layer, as evidenced by the presence of a Pt−O coordination shell at 2.00 Å. These results demonstrate that in situ EXAFS of supported Pt electrocatalysts may be used to probe adsorbate structures.
The Origin of Highly Elevated Cell-Free DNA in Healthy Individuals and Patients with Pancreatic, Colorectal, Lung, or Ovarian Cancer (2023)

The origin of excess cfDNA in patients with cancer is unknown. Using cfDNA methylation patterns, we determined that neither the tumor nor the surrounding normal tissue contributes this excess cfDNA-rather it comes from leukocytes. This finding suggests that cancers have a systemic impact on cell turnover or DNA clearance. See related commentary by Thierry and Pisareva, p. 2122. This article is featured in Selected Articles from This Issue, p. 2109.
Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-XL Inhibitor (2020)

Herein we describe the discovery of A-1331852, a first-in-class orally active BCL-X<sub>L</sub> inhibitor that selectively and potently induces apoptosis in BCL-X<sub>L</sub>-dependent tumor cells. This molecule was generated by re-engineering our previously reported BCL-X<sub>L</sub> inhibitor A-1155463 using structure-based drug design. Key design elements included rigidification of the A-1155463 pharmacophore and introduction of sp<sup>3</sup>-rich moieties capable of generating highly productive interactions within the key P4 pocket of BCL-X<sub>L</sub>. A-1331852 has since been used as a critical tool molecule for further exploring BCL-2 family protein biology, while also representing an attractive entry into a drug discovery program.
Particle Films for Suppression of the Codling Moth (Lepidoptera: Tortricidae) in Apple and Pear Orchards (2000)

Studies were conducted in 1997 and 1998 to evaluate the effects of three particle film formulations consisting of kaolin and adjuvants on neonate larvae, ovipositing adult females, and eggs of the codling moth, Cydia pomonella (L.). Neonate larval walking speed, fruit discovery rate, and fruit penetration rate on apple host plants coated with particle films were significantly lower than on host plants without particle films in laboratory assays. Females oviposited less on host plants covered with a particle film residue than on untreated plants in laboratory choice and no-choice tests. Hatch rate of codling moth neonate larvae was unaffected by particle films sprayed on host plants either before or after oviposition. Fruit infestation rates were significantly reduced on particle film-treated trees compared with untreated trees for both first- and second-generation codling moth in field trials in both apple and pear orchards. Particle films appear to be a promising supplemental control approach for codling moth in orchards where moth density is high, and may represent a stand-alone method where moth densities are lower.
Detection of Merkel cell virus and correlation with histologic presence of Merkel cell carcinoma in sentinel lymph nodes (2012)

Patients with positive SLN for MCV even if negative by histopathology were identified. The application of molecular techniques to detect subhistologic disease in SLN of MCC patients may identify a subset of patients who would benefit from adjuvant nodal treatment.
A phase-change via-reconfigurable on-chip inductor (2010)

This paper describes a new approach to the realization of reconfigurable CMOS-compatible RF inductors using programmable vias made from phase-change (PC) materials. Reversible reconfiguration of a custom-fabricated inductor prototype is demonstrated using voltage pulses to transform (by Joule heating) the PC switch between crystalline (ON) and amorphous (OFF) states. The RF performance shows an inductance of 1.9 (0.9) nH at 2 (5) GHz with quality factor (Q) of 12.4 (5.8) in the OFF (ON) state.
A Carbon NanohornPorphyrin Supramolecular Assembly for Photoinduced Electron‐Transfer Processes (2010)

A supramolecular assembly of zinc porphyrin-carbon nanohorns (CNHs) was constructed in a polar solvent. An ammonium cation was covalently connected to the CNH through a spacer (sp) (CNH-sp-NH(3)(+)) and bound to a crown ether linked to a zinc porphyrin (Crown-ZnP). Nanohybrids CNH-sp-NH(3)(+);Crown-ZnP and CNH-sp-NH(3)(+) were characterized by several techniques, such as high-resolution transmission electron microscopy, thermogravimetric analysis, X-ray photoelectron spectroscopy, and Raman spectroscopy. The photoinduced electron-transfer processes of the nanohybrids have been confirmed by using time-resolved absorption and fluorescence measurements by combining the steady-state spectral data. Fluorescence quenching of the ZnP unit by CNH-sp-NH(3)(+) has been observed, therefore, photoinduced charge separation through the excited singlet state of the ZnP unit is suggested for the hybrid material, CNH-sp-NH(3)(+);Crown-ZnP. As transient absorption spectral experiments reveal the formation of the radical cation of the ZnP unit, electron generation is suggested as a counterpart of the charge-separation on the CNHs; such an electron on the CNHs is further confirmed by migrating to the hexylviologen dication (HV(2+)). Accumulation of the electron captured from HV(*+) is observed as electron pooling in solution in the presence of a hole-shifting reagent. Photovoltaic performance with moderate efficiency is confirmed for CNH-sp-NH(3)(+);Crown-ZnP deposited onto nanostructured SnO(2) films.
Clinical Adjuvant Combinations Stimulate Potent B-Cell Responses In Vitro by Activating Dermal Dendritic Cells (2013)

CD14(+) dermal DCs (CD14(+) DDCs) have a natural capacity to activate naïve B-cells. Targeting CD14(+) DDCs is therefore a rational approach for vaccination strategies aimed at improving humoral responses towards poorly immunogenic antigens, for example, HIV-1 envelope glycoproteins (Env). Here, we show that two clinically relevant TLR ligand combinations, Hiltonol plus Resiquimod and Glucopyranosyl lipid A plus Resiquimod, potently activate CD14(+) DDCs, as shown by enhanced expression of multiple cytokines (IL-6, IL-10, IL-12p40 and TNF-α). Furthermore, the responses of CD14(+) DDCs to these TLR ligands were not compromised by the presence of HIV-1 gp120, which can drive immunosuppressive effects in vitro and in vivo. The above TLR ligand pairs were better than the individual agents at boosting the inherent capacity of CD14(+) DDCs to induce naïve B-cells to proliferate and differentiate into CD27(+) CD38(+) B-cells that secrete high levels of immunoglobulins. CD14(+) DDCs stimulated by these TLR ligand combinations also promoted the differentiation of Th1 (IFN-γ-secreting), but not Th17, CD4(+) T-cells. These observations may help to identify adjuvant strategies aimed at inducing better antibody responses to vaccine antigens, including, but not limited to HIV-1 Env.
LiNbO3 thin film for A1 mode of Lamb wave resonators (2011)

Abstract Currently, a high frequency device more than 3 GHz is required. High frequency resonators with resonant frequencies of 4.5 and 6.3 GHz were fabricated by utilizing an anti‐symmetric first mode (A 1 ) of a Lamb wave having a high velocity consisting of a thin LiNbO 3 film deposited by a chemical vapor deposition (CVD) system. By measuring polarities of their LiNbO 3 films, it was clarified that the thinner film had a large mixture of +c and −c domains, and the occupation ratio of main polarity influenced their frequency characteristics.
Selection of drug-resistant HIV-1 mutants in response to repeated structured treatment interruptions (2002)

Drug-resistant virus can rise to high frequencies in chronically HIV-1 infected individuals during consecutive STIs. Evolution of resistance is likely to be more important in patients with prior suboptimal therapies, particularly when few mutations are required for resistance. Maximum care should be taken in designing STI protocols that minimize development of drug-resistant mutations that may lead to treatment failure. Thus, drug-resistance testing may be useful before restarting treatment during STI studies.
Instantaneous measurement of left and right ventricular stroke volume and pressure-volume relationships with an impedance catheter. (1984)

The feasibility of using continuous on-line recording of intraventricular electrical impedance to measure ventricular stroke volume was assessed in 12 patients at cardiac catheterization with a multielectrode impedance catheter and a 1.3 kHz measuring current of 4 microA. Stroke volumes determined by electrical impedance were compared with stroke volumes determined by the thermodilution technique in 10 patients and correlated with an r value of .95. Directional changes in impedance recordings throughout the cardiac cycle were also compared with volume curves obtained from six patients by radionuclide ventriculography, and in all instances the agreement between the two volume recordings was excellent. For all patients, on-line measurements of impedance showed a beat-by-beat decrease in stroke volume with the Valsalva maneuver and the administration of amyl nitrite, as well as an immediate increase in stroke volume in the contraction following an extra-systolic beat. Similar directional changes in stroke volume were recorded in both left and right ventricles. Left ventricular pressure-volume relationships were assessed with simultaneous left ventricular pressure recordings and volume signals recorded from the impedance catheter to determine if impedance measurements of volume can be used clinically. Pressure-volume diagrams were subsequently plotted, and for all patients these diagrams showed characteristic isovolumetric contraction and relaxation phases as well as typical ejection and filling periods. Moreover, beat-by-beat sequential pressure-volume diagrams constructed for patients during the administration of amyl nitrite revealed a linear end-systolic pressure-volume relationship.(ABSTRACT TRUNCATED AT 250 WORDS)
MRI of the Inner Ear (2000)

Axial TSE images, MIPs, and 3D volume reconstructions are complementary modalities that provide different information. Our results suggest that improved diagnostic information can be obtained by applying these volume visualization reconstruction techniques.
New Preparative Chemistry of Silicon-Nitrogen-Phosphorus Compounds (1994)

Abstract Compounds containing the Si-N-P linkage, especially (silylamino)phosphines, (Me3Si)2NPR2, and N-silylphosphoranimines, Me3SiN=PR2X, are of interest as precursors to polyphosphazenes and/or other phosphorus-based polymer systems or to new types of organophosphorus or phosphorus-nitrogen compounds. In addition to reviewing the general preparative chemistry of these Si-N-P systems, this report describes some recent results on the synthesis and characterization of three new types of P-N compounds that either contain or were prepared from Si-N-P linkages. The new systems include; (1) a series of acetylene-substituted (silylamino)phosphines and N-silylphosphoranimines, (2) three types of aminoborane derivatives of N-silylphosphoranimines, and (3) several N-phosphoryl substituted phosphoranimines.
Profiling of Human Serum Glycans Associated with Liver Cancer and Cirrhosis by IMS−MS (2008)

Aberrant glycosylation of human glycoproteins is related to various physiological states, including the onset of diseases such as cancer. Consequently, the search for glycans that could be markers of diseases or targets of therapeutic drugs has been intensive. Here, we describe a high-throughput ion mobility spectrometry/mass spectrometry analysis of N-linked glycans from human serum. Distributions of glycans are assigned according to their m/z values, while ion mobility distributions provide information about glycan conformational and isomeric composition. Statistical analysis of data from 22 apparently healthy control patients and 39 individuals with known diseases (20 with cirrhosis of the liver and 19 with liver cancer) shows that ion mobility distributions for individual m/z ions appear to be sufficient to distinguish patients with liver cancer or cirrhosis. Measurements of glycan conformational and isomeric distributions by IMS-MS may provide insight that is valuable for detecting and characterizing disease states.
High harmonics from solid surfaces as a source of ultra-bright XUV radiation for experiments (2008)

The coherent high-order harmonic generation from the interaction of ultra-intense femtosecond laser pulses with solid density plasmas holds promise for tabletop sources of extreme ultraviolet (XUV) and soft x-ray radiation with attosecond duration and unprecedented intensities. Together with the generation of mono-energetic electron beams from gas jets and capillaries and the generation of mono-energetic ions from thin foils, this offers a unique tool box of tabletop-laser-generated radiation sources for a wide range of applications previously only accessible with large-scale accelerator and synchrotron- radiation facilities. Especially, the generation of high harmonics from laser plasmas has the potential of being applied to a wide range of experiments from plasma physics to molecular dynamics. So far the studies addressing the generation of high harmonics from laser-generated overcritical plasma surfaces have concentrated mainly on the characterization of the harmonic beams themselves not considering how, in a next step, these beams could be applied to experiments. In this paper we discuss the generation of surface harmonics with the ATLAS (800 mJ, 40 fs) laser system with the emphasis on the transport, spectral shaping refocusing of the harmonic beams, all of these being absolute prerequisites for multi-shot experiments. We also present considerations for future improvements and possible future experiments exploiting the full potential of high harmonic radiation from solid targets. © 2008 IOP Publishing Ltd.
Radio resource management in HSDPA and HSUPA (2007)

This paper discusses the interaction between high speed downlink packet access (HSDPA) and high speed uplink packet access (HSUPA) scheduling algorithms running in the Node B and other resource management algorithms in the radio network controller (RNC), which are still required to satisfy user-perceived quality. We investigate the effect of load sharing with legacy dedicated channel transmission, and discuss load control algorithms suitable for HSDPA and HSUPA packet transmission. The main concepts of resource allocation are discussed together with results obtained from a dynamic system simulator developed by Alcatel-Lucent. © 2007 Alcatel-Lucent.