gebhart/patrepeval huggingface dataset:
Decreasing Hospitalization of the Cyclosporine Treated Renal Allograft Recipient (1987)

No AccessJournal of Urology1 Jun 1987Decreasing Hospitalization of the Cyclosporine Treated Renal Allograft Recipient Martin A. Koyle, Jacob Rajfer, Mark B. Sender, Richard J. Glassock, and Harry J. Ward Martin A. KoyleMartin A. Koyle More articles by this author , Jacob RajferJacob Rajfer More articles by this author , Mark B. SenderMark B. Sender More articles by this author , Richard J. GlassockRichard J. Glassock More articles by this author , and Harry J. WardHarry J. Ward More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)76040-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Decreasing Hospitalization of the Cyclosporine Treated Renal Allograft Recipient." The Journal of Urology, 137(6), p. 326A © 1987 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 137Issue 6June 1987Page: 326A Advertisement Copyright & Permissions© 1987 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Martin A. Koyle More articles by this author Jacob Rajfer More articles by this author Mark B. Sender More articles by this author Richard J. Glassock More articles by this author Harry J. Ward More articles by this author Expand All Advertisement PDF downloadLoading ...
Advanced Contactless Analysis of Plasma-Induced Damage on Si by Temperature-Controlled Photoreflectance Spectroscopy (2011)

We propose an advanced photoreflectance (PR) spectroscopy technique, for use as a method for the contactless analysis of plasma-induced damage (physical damage) on Si. Si wafers damaged by Ar plasma were placed on a measurement stage capable of sample cooling by liquid nitrogen. In comparison to the spectra at 300 K, the signal intensity at 90 K was increased by cooling. A spectral peak of a heavily-damaged sample was identified at 90 K, which was difficult at 300 K. Changes in the surface potential induced by plasma exposure (ΔVs) were calculated by analyzing the spectral parameters. Areal densities of trapped charges were estimated from ΔVs. The temperature dependence of the PR spectra was discussed, and the primary cause of the increase in signal intensity was attributed to the reduced electron–phonon interactions in a lower temperature range. The proposed technique expands the applicable range of PR-based damage analysis.
Dynamics of Rydberg states of nitric oxide probed by two-color resonant four-wave mixing spectroscopy (1998)

Two-color resonant four-wave mixing (TC-RFWM) spectroscopy has been used to probe highly excited v=0 and v=1 Rydberg states of nitric oxide. Transitions to n=16–30, v=0, Rydberg states, and the 8p, 9p, 7f, 8f, 8s, and 9s, v=1 Rydberg states from the A 2Σ+, v′=0 and 1 states have been recorded. The decay rate of the 8p and 9p, v=1 states has been extracted from the observed line profiles by using a recently developed model for the excitation of quasibound resonances in TC-RFWM spectroscopy. Transitions from the A 2Σ+, v′=1 state to the X 2Π3/2, v″=10 state have also been observed, allowing an absolute calibration of the TC-RFWM signal intensity. This calibration is used to determine an excited-state absorption cross section for the 9p, v=1 Rydberg state.
NAMPT/Visfatin expression by inflammatory monocytes mediates arthritis pathogenesis by promoting IL-17–producing T cells (2012)

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Integrated GeSi Electro-Absorption Modulators on SOI (2008)

We demonstrate 1.2 GHz waveguide-integrated GeSi electro-absorption modulators on SOI platform with an extinction ratio of &gt;7 dB over a broad wavelength range of 1510–1552 nm and an ultralow energy consumption of 50 fJ/bit.
ChemInform Abstract: Ring Expansion of Substituted Norbornadienes for the Synthesis of Mono‐ and Disubstituted 2‐Azabicyclo[3.2.1]octadienes. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Strain assisted abnormal grain growth in nickel base superalloys (2013)

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1402 Augmented glucose dependency of autoreactive B cells provides a treatment target for lupus (2021)

<h3>Background</h3> Lupus is an autoimmune disease characterized by antibodies directed against nuclear components that induce immune complex-mediated injury to multiple organs. Underlying lupus is the induction of T-cell-dependent activation and clonal expansion of autoreactive B cells in germinal centers resulting in their differentiation into plasma cells that secrete pathogenic autoantibodies. Heightened glucose metabolism is inherent to immune/inflammatory disorders, but little is known of its role in lupus etiology. Present treatments for lupus rely heavily on broad-spectrum immunosuppressive agents, and there is a need for targeted therapies that effectively counteract this systemic autoimmune disorder. <h3>Methods</h3> Here we examined the metabolic and gene expression profiles of key autoimmune populations in mouse models of spontaneous lupus and their responses to treatment with the glycolysis inhibitor 2-deoxyglucose (2DG) in drinking water. Therapeutic efficacy in terms of survival after long- vs. short-term 2DG-exposed times was assessed on BXSB.<i>Yaa</i> and NZBWF1 lupus-prone mice. Furthermore, a chimeric antigen receptor (CAR)-T immunotherapy was used to determine whether a targeted removal of an identified B cell subset can improve disease outcomes. <h3>Results</h3> We found greater glucose uptake and glycolysis rate in spontaneous germinal center B cells (GCB) compared to that in follicular helper T cells (Tfh). The differential dependency on glucose oxidation between GCB and Tfh was determined, rendering GCB highly susceptible to oxidative stress-induced apoptosis triggered by glycolysis inhibition via 2DG. Short-term glycolytic inhibition selectively targeted GCB, sparing other autoreactive populations, including Tfh. This reduction of GCB is, in turn, responsible for improving kidney function and lifespan of treated mice. Moreover, we identified a subset of GCB, which express TNFSF17 and exhibit a higher reliance on glucose metabolism than TNFSF17<sup>-</sup> GCB. Their depletion through its ligand TNFSF13-based CAR-T treatment significantly decreased mortality from lupus. <h3>Conclusions</h3> Differential metabolic requirement for glucose between autoreactive GCB and Tfh dictates different sensitivity to apoptosis via glycolytic inhibition, and this provides a metabolic niche for targeted lupus treatment. Combining therapies that selectively dampen GCB metabolism for survival with T cell-based immunotherapy could provide new effective treatments for lupus. <h3>Acknowledgments</h3> We thank the funding resources from JAX Director Initiative Fund, the RILITE Foundation, and the John and Marcia Goldman Foundation.
SIGNALS TRANSDUCED BY THE COMMON ?? CHAIN OF CYTOKINE RECEPTORS ARE CRITICAL IN ALLOGRAFT REJECTION (1998)

117 T cell growth factors (TCGFs) play a critical role in allograft rejection. TCGFs upon binding to their cell surface receptors promote the growth and differentiation of alloreactive T cells. The γc chain is a shared signaling component by receptors for IL-2, IL-4, IL-7, IL-9, and IL-15, all potent TCGFs. In the present study, we examined the role of γc chain transduced signals in rejection of islet allografts in mice. Crude DBA/2J(H-2d) islets were transplanted under the renal capsule into B6AF1(H-2b/d.k) recipients rendered diabetic by a single i.p. injection of stretozotocin (225mg/kg). Recipient mice were treated with two blocking anti-γc chain mAbs (4G3/3E12) or isotype control antibody on days 0, 1, 3, 7 post transplantation (0.5mg/injection i.p.). Islet allograft survival was summarized below: TableQRT-PCR analysis also revealed decreased intragraft expression of immune activation genes following anti-γc treatment. Conclusion: our data establish that the γc chain transduced signals are critical in the execution of allograft rejection.
SiO2/Grooved Al Electrode/LiTaO3 and Edge-Reflection Surface Acoustic Wave Structures Having Large Reflection Coefficient, Large Coupling Factor, and Excellent Temperature Characteristic Even If Al Electrodes Are Used (2006)

SiO2/Grooved Al Electrode/LiTaO3 and Edge-Reflection Surface Acoustic Wave Structures Having Large Reflection Coefficient, Large Coupling Factor, and Excellent Temperature Characteristic Even If Al Electrodes Are Used, Michio Kadota, Tetsuya Kimura
Real-Time Image-Based Volume Lighting (2013)

The interaction of translucent objects with light creates complex effects such as scattering, absorption and volumetric shadows. While most accurate rendering approaches resort to heavy computations, recent needs in interactive applications have led to new types of algorithms, trading quality or genericity for speed.
The two domains of centrin have distinct basal body functions inTetrahymena (2011)

The basal body is a microtubule-organizing center responsible for organizing the cilium, a structure important for cell locomotion and sensing of the surrounding environment. A widely conserved basal body component is the Ca(2+)-binding protein centrin. Analyses of centrin function suggest a role in basal body assembly and stability; however, its molecular mechanisms remain unclear. Here we describe a mutagenic strategy to study the function and essential nature of the various structural features of Cen1 in the ciliate Tetrahymena. We find that the two domains of Cen1 are both essential, and examination of strains containing mutant CEN1 alleles indicates that there are two predominant basal body phenotypes: misorientation of newly assembled basal bodies and stability defects. The results also show that the two domains of Cen1 are able to bind Ca(2+) and that perturbation of Ca(2+) binding affects Cen1 function. In all, the data suggest that the two domains of Cen1 have distinct functions.
Increasing the Corrosion Resistance of Mullite-based Catalyst Substrates in a Vehicle Exhaust Environment (2013)

Extended abstract of a paper presented at Microscopy and Microanalysis 2013 in Indianapolis, Indiana, USA, August 4 – August 8, 2013.
The O2-independent pathway of ubiquinone biosynthesis is essential for denitrification in Pseudomonas aeruginosa (2020)

Many proteobacteria, such as <i>Escherichia coli</i>, contain two main types of quinones: benzoquinones, represented by ubiquinone (UQ) and naphthoquinones, such as menaquinone (MK), and dimethyl-menaquinone (DMK). MK and DMK function predominantly in anaerobic respiratory chains, whereas UQ is the major electron carrier in the reduction of dioxygen. However, this division of labor is probably not very strict. Indeed, a pathway that produces UQ under anaerobic conditions in an UbiU-, UbiV-, and UbiT-dependent manner has been discovered recently in <i>E. coli</i> Its physiological relevance is not yet understood, because MK and DMK are also present in <i>E. coli</i> Here, we established that UQ<sub>9</sub> is the major quinone of <i>Pseudomonas aeruginosa</i> and is required for growth under anaerobic respiration (<i>i.e.</i> denitrification). We demonstrate that the ORFs <i>PA3911</i>, <i>PA3912</i>, and <i>PA3913</i>, which are homologs of the <i>E. coli ubiT</i>, <i>ubiV</i>, and <i>ubiU</i> genes, respectively, are essential for UQ<sub>9</sub> biosynthesis and, thus, for denitrification in <i>P. aeruginosa</i> These three genes here are called <i>ubiT<sub>Pa</sub></i> , <i>ubiV<sub>Pa</sub></i> , and <i>ubiU<sub>Pa</sub></i> We show that UbiV<sub>Pa</sub> accommodates an iron-sulfur [4Fe-4S] cluster. Moreover, we report that UbiU<sub>Pa</sub> and UbiT<sub>Pa</sub> can bind UQ and that the isoprenoid tail of UQ is the structural determinant required for recognition by these two Ubi proteins. Since the denitrification metabolism of <i>P. aeruginosa</i> is believed to be important for the pathogenicity of this bacterium in individuals with cystic fibrosis, our results highlight that the O<sub>2</sub>-independent UQ biosynthetic pathway may represent a target for antibiotics development to manage <i>P. aeruginosa</i> infections.
Discovery of Checkpoint Kinase Inhibitor (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by Structure-Based Design and Optimization of Thiophenecarboxamide Ureas (2012)

Checkpoint kinases CHK1 and CHK2 are activated in response to DNA damage that results in cell cycle arrest, allowing sufficient time for DNA repair. Agents that lead to abrogation of such checkpoints have potential to increase the efficacy of such compounds as chemo- and radiotherapies. Thiophenecarboxamide ureas (TCUs) were identified as inhibitors of CHK1 by high throughput screening. A structure-based approach is described using crystal structures of JNK1 and CHK1 in complex with 1 and 2 and of the CHK1-3b complex. The ribose binding pocket of CHK1 was targeted to generate inhibitors with excellent cellular potency and selectivity over CDK1and IKKβ, key features lacking from the initial compounds. Optimization of 3b resulted in the identification of a regioisomeric 3-TCU lead 12a. Optimization of 12a led to the discovery of the clinical candidate 4 (AZD7762), which strongly potentiates the efficacy of a variety of DNA-damaging agents in preclinical models.
Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells (2018)

Type I interferon (IFN) is a key driver of immunity to infections and cancer. Plasmacytoid dendritic cells (pDCs) are uniquely equipped to produce large quantities of type I IFN but the mechanisms that control this process are poorly understood. Here we report on a droplet-based microfluidic platform to investigate type I IFN production in human pDCs at the single-cell level. We show that type I IFN but not TNFα production is limited to a small subpopulation of individually stimulated pDCs and controlled by stochastic gene regulation. Combining single-cell cytokine analysis with single-cell RNA-seq profiling reveals no evidence for a pre-existing subset of type I IFN-producing pDCs. By modulating the droplet microenvironment, we demonstrate that vigorous pDC population responses are driven by a type I IFN amplification loop. Our study highlights the significance of stochastic gene regulation and suggests strategies to dissect the characteristics of immune responses at the single-cell level.
Choice, interoperability, and conformance in interaction protocols and service choreographies (2009)

Many real-world applications of multiagent systems require independently designed (heterogeneous) and operated (autonomous) agents to interoperate. We consider agents who offer business services and collaborate in interesting business service engagements. We formalize notions of interoperability and conformance, which appropriately support agent heterogeneity and autonomy. With respect to autonomy, our approach considers the choices that each agent has, and how their choices are coordinated so that at any time one agent leads and its counterpart follows, but with initiative fluidly shifting among the participants. With respect to heterogeneity, we characterize the variations in the agents' designs, and show how an agent may conform to a specification or substitute for another agent. Our approach addresses a challenging problem with multi-party interactions that existing approaches cannot solve. Further, we introduce a set of edit operations by which to modify an agent design so as to ensure its conformance with others.
Representation Theory (1983)

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Raman fiber laser pumped by a semiconductor disk laser and mode locked by a semiconductor saturable absorber mirror (2010)

A 1.6µm mode-locked Raman fiber laser pumped by a 1480nm semiconductor disk laser is demonstrated. Watt-level core pumping of the single-mode fiber Raman lasers with low-noise disk lasers together with semiconductor saturable absorber mirror mode locking represents a highly practical solution for short-pulse operation.
VLDL-specific increases of fatty acids in autism spectrum disorder correlate with social interaction (2020)

This study was supported mainly by MEXT, Japan.
Human Uteroglobin Gene: Structure, Subchromosomal Localization, and Polymorphism (1997)

Human uteroglobin (hUG) or Clara cell 10-kD protein (cc10 kDa) is a steroid-dependent, immunomodulatory, cytokine-like protein. It is secreted by mucosal epithelial cells of all vertebrates studied. The cDNA encoding hUG and the 5' promoter region of the gene have been characterized previously. Here, we report that the structure of the entire hUG gene is virtually identical to those of rabbit, rat, and mouse. It is localized on human chromosome 11q12.3-13.1, a region in which several important candidate disease genes have been mapped by linkage analyses. Our data indicate that candidate genes for atopic (allergic) asthma and Best's vitelliform macular dystrophy are in closest proximity to the hUG gene. To determine whether hUG gene mutation may be involved in the pathogenesis of these diseases, we studied two isolated groups of patients, each afflicted with either atopy or Best's disease, respectively. We detected a single base-pair change in the hUG gene in Best's disease patients and normal controls but no such change was detected in atopy patients. This alteration in hUG gene-sequence in Best disease family appears to be a polymorphism. Although the results of our investigation did not uncover mutations in hUG gene that could be causally related to the pathogenesis of either of these diseases, its conservation throughout vertebrate phyla implies that this gene is of physiological importance. Moreover, the close proximity of this gene to several candidate disease genes makes it an important chromosomal marker in cloning and characterization of those genes.
Full-chip sub-threshold leakage power prediction model for sub-0.18 /spl mu/m CMOS (2002)

The driving force for the semiconductor industry growth has been the elegant scaling nature of CMOS technology. In future CMOS technology generations, supply and threshold voltages will have to continually scale to sustain performance increase, control switching power dissipation, and maintain reliability. These continual scaling requirements on supply and threshold voltages pose several technology and circuit design challenges. With threshold voltage scaling sub-threshold leakage power is expected to become a significant portion of the total power in future CMOS systems. Therefore, it becomes crucial to predict sub-threshold leakage power of such systems. In this paper, we present a subthreshold leakage power prediction model that takes into account within-die threshold voltage variation. Statistical measurements of 32-bit microprocessors in 0.18 /spl mu/m CMOS confirms the mean error of the model to be 4%. Comparisons of this model to two other existing models that do not take within-die threshold voltage variation into account are also presented.
The Stability of Percutaneous Fixation of Proximal Humeral Fractures (2010)

Castoldi, F. MD; Bonasia, D.E. MD; Blonna, D. MD; Rossi, R. MD; Dettoni, F. MD; Assom, M. MD; Sankey, A. MA, FRCS(Orth); Halewood, C. MEng, MBiomedE; Amis, A.A. PhD, DSc(Eng) Author Information
ChemInform Abstract: Orchestrated Triple C—H Activation Reactions Using Two Directing Groups: Rapid Assembly of Complex Pyrazoles. (2015)

Abstract A sequential triple C—H activation reaction directed by a pyrazole and an amide group leads to the well‐controlled construction of sterically congested dihydrobenzo[e]indazole derivatives.
Inactivation of growth differentiation factor 9 blocks folliculogenesis in pigs (2023)

Growth differentiation factor 9 (GDF9) is a secreted protein belonging to the transforming growth factor beta superfamily and has been well characterized for its role during folliculogenesis in the ovary. Although previous studies in mice and sheep have shown that mutations in GDF9 disrupt follicular progression, the exact role of GDF9 in pigs has yet to be elucidated. The objective of this study was to understand the role of GDF9 in ovarian function by rapidly generating GDF9 knockout (GDF9-/-) pigs by using the CRISPR/Cas9 system. Three single-guide RNAs designed to disrupt porcine GDF9 were injected with Cas9 mRNA into zygotes, and blastocyst-stage embryos were transferred into surrogates. One pregnancy was sacrificed on day 100 of gestation to investigate the role of GDF9 during oogenesis. Four female fetuses were recovered with one predicted to be GDF9-/- and the others with in-frame mutations. All four had fully formed oocytes within primordial follicles, confirming that knockout of GDF9 does not disrupt oogenesis. Four GDF9 mutant gilts were generated and were grown past puberty. One gilt was predicted to completely lack functional GDF9 (GDF9-/-), and the gilt never demonstrated standing estrus and had a severely underdeveloped reproductive tract with large ovarian cysts. Further examination revealed that the follicles from the GDF9-/- gilt did not progress past preantral stages, and the uterine vasculature was less extensive than the control pigs. By using the CRISPR/Cas9 system, we demonstrated that GDF9 is a critical growth factor for proper ovarian development and function in pigs.
Procollagen III peptide (PIIIP): Can it reflect hepatic fibrosis? (1987)

Immunolocalization of type III collagen and procollagen in cirrhotic human liver was studied using monoclonal antibody specific for the helical determinant of type III collagen extracted from human placenta. Deparaffinized, trypsin-treated cirrhotic liver sections from 8 autopsy cases were examined by the unlabeled peroxidase-antiperoxidase and immunofluorescence techniques. These techniques revealed the localization of this epitope shared by type III collagen and procollagen not only in the extracellular matrix of hepatocytes and sinusoidal cells but also in the cytoplasm. In hepatocellular carcinoma concurrent with cirrhosis, neoplastic cells were shown to react with this antibody as well. These results are consistent with data obtained using antiserum specific for bovine type III procollagen aminopeptide which appeared in our previous report.
A 112-Gbps, 0.73-pJ/bit Fully-Integrated O-band I-Q Optical Receiver in a 45-nm CMOS SOI-Photonic Process (2023)

A 1310-nm (O-band) coherent optical receiver (CORX) is demonstrated with a monolithic electronic/photonic integrated circuit (MEPIC) process for short range optical interconnects. The CORX is designed using a 45-nm CMOS SOI photonic process for quadrature phase shift keying (QPSK) and includes I/Q channels that are characterized up to 56 GBaud (112 Gbps) with FEC-acceptable BER. The receiver achieves 0.73 p.l/bit energy efficiency and, to our knowledge, is the best energy efficiency reported for a coherent optical receiver.