gebhart/patrepeval huggingface dataset:
Recrystallization of Bi<sub>88</sub>Sb<sub>12</sub> thermoelectric semiconductors processed by High Pressure Torsion (2011)

Bi88Sb12 was prepared by mechanical grinding (MG) followed by hot pressing. The disks were cut and then deformed using high pressure torsion (HPT) at 373 K under a pressure of 6.0 GPa. The number of turns in the HPT process was either one or five. Metallurgical and structural characterizations were performed using scanning electron microscopy, differential thermal analysis, X-ray diffraction, and Vickers microhardness measurements. The thermoelectric properties were estimated by measuring the thermal and electrical conductivities, and the Hall and Seebeck coefficients. The HPT samples prepared using one turn were homogeneous and finely grained; those prepared using five turns were coarse grained. The results indicated that grain growth occurred after HPT deformation, which was consistent with the microhardness results. The thermal conductivity of the as-sintered MG sample was 2.83 W m−1 K−1 at room temperature, which was lower than values previously reported for samples prepared by mechanical alloying (MA). The power factors of the HPT samples were almost the same as that of the as-sintered MG sample.
An intelligent MOS transistor featuring gate-level weighted sum and threshold operations (2002)

A novel functional MOS transistor which behaves much more intelligently than a mere switching device has been developed. The device has a floating gate whose potential is controlled by a plural number of input gates via capacitive coupling. The transistor is called a 'neuron MOSFET' due to its similarity to biological neurons in that the transistor turns on when the weighted sum of all input signals exceeds a certain threshold value. Test devices were fabricated using a double-polysilicon NMOS process. The analysis of the basic device operation and its experimental verification are presented. A number of interesting applications of the neuron MOSFET are described which include a variable threshold transistor, a neuron circuit, a single-gate D/A (digital-to-analog) converter, and a soft hardware logic circuit.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Frustration in Super‐Ionic Conductors Unraveled by the Density of Atomistic States (2023)

Abstract The frustration in super‐ionic conductors enables their exceptionally high ionic conductivities, which are desired for many technological applications including batteries and fuel cells. A key challenge in the study of frustration is the difficulties in analyzing a large number of disordered atomistic configurations. Using lithium super‐ionic conductors as model systems, we propose and demonstrate the density of atomistic states (DOAS) analytics to quantitatively characterize the onset and degree of disordering, reveal the energetics of local disorder, and elucidate how the frustration enhances diffusion through the broadening and overlapping of the energy levels of atomistic states. Furthermore, material design strategies aided by the DOAS are devised and demonstrated for new super‐ionic conductors. The DOAS is generally applicable analytics for unraveling fundamental mechanisms in complex atomistic systems and guiding material design.
Application of Bayesian Inversion of Electromagnetic Induction Data for UXO Discrimination (2003)

PreviousNext No AccessSymposium on the Application of Geophysics to Engineering and Environmental Problems 2003Application of Bayesian Inversion of Electromagnetic Induction Data for UXO DiscriminationAuthors: Keli SunKevin O'NeillLanbo LiuFridon ShubitidzeIrma ShamatavaKeli SunDartmouth College, Hanover NH, Kevin O'Neill, Lanbo Liu, Fridon ShubitidzeDartmouth College, Hanover NH, and Irma ShamatavaDartmouth College, Hanover NHhttps://doi.org/10.4133/1.2923154 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Abstract Introductory paragraph for this paper is available only in the PDF and GZipped PS filesPermalink: https://doi.org/10.4133/1.2923154FiguresReferencesRelatedDetailsCited ByAccounting for the effects of widespread discrete clutter in subsurface EMI remote sensing of metallic objectsIEEE Transactions on Geoscience and Remote Sensing, Vol. 44, No. 1 Symposium on the Application of Geophysics to Engineering and Environmental Problems 2003ISSN (online):1554-8015Copyright: 2003 Pages: 1491 publication data© 2003 Copyright © 2003 The Environmental and Engineering Geophysical SocietyPublisher:Environmental & Engineering Geophysical Society HistoryPublished: 30 Sep 2008 CITATION INFORMATION Keli Sun, Kevin O'Neill, Lanbo Liu, Fridon Shubitidze, and Irma Shamatava, (2003), "Application of Bayesian Inversion of Electromagnetic Induction Data for UXO Discrimination," Symposium on the Application of Geophysics to Engineering and Environmental Problems Proceedings : 1469-1478. https://doi.org/10.4133/1.2923154 Plain-Language Summary PDF DownloadLoading ...
Ultra-fast 31 kHz interrogation of FBG sensors using FDML wavelength swept laser (2008)

Ultra-fast 31.3 kHz interrogation is newly demonstrated for fiber Bragg grating (FBG) sensor system using Fourierdomain
mode-locked (FDML) wavelength-swept laser. Higher speed interrogations are useful for the real-time
monitoring of dynamic sloshing pressure and strain.
Differential effects of tamoxifen-like compounds on osteoclastic bone degradation, H+-ATPase activity, calmodulin-dependent cyclic nucleotide phosphodiesterase activity, and calmodulin binding (1997)

We studied effects of calmodulin antagonists on osteoclastic activity and calmodulin-dependent HCl transport. The results were compared to effects on the calmodulin-dependent phosphodiesterase and antagonist-calmodulin binding affinity. Avian osteoclast degradation of labeled bone was inhibited approximately 40% by trifluoperazine or tamoxifen with half-maximal effects at 1-3 microM. Four benzopyrans structurally resembling tamoxifen were compared: d-centchroman inhibited resorption 30%, with half-maximal effect at approximately 100 nM, cischroman and CDRI 85/287 gave 15-20% inhibition, and l-centchroman was ineffective. No benzopyran inhibited cell attachment or protein synthesis below 10 microM. However, ATP-dependent membrane vesicle acridine transport showed that H(+)-ATPase activity was abolished by all compounds with 50% effects at 0.25-1 microM. All compounds also inhibited calmodulin-dependent cyclic nucleotide phosphodiesterase at micromolar calcium. Relative potency varied with assay type, but d- and l-centchroman, surprisingly, inhibited both H(+)-ATPase and phosphodiesterase activity at similar concentrations. However, d- and l-centchroman effects in either assay diverged at nanomolar calcium. Of benzopyrans tested, only the d-centchroman effects were calcium-dependent. Interaction of compounds with calmodulin at similar concentrations were confirmed by displacement of labeled calmodulin from immobilized trifluoperazine. Thus, the compounds tested all interact with calmodulin directly to varying degrees, and the observed osteoclast inhibition is consistent with calmodulin-mediated effects. However, calmodulin antagonist activity varies between specific reactions, and free calcium regulates specificity of some interactions. Effects on whole cells probably also reflect other properties, including transport into cells.
[Plasma lipoproteins and multiple myeloma. Variations of lipid constituents of HDL and apolipoproteins A1 and B]. (1983)

Patients with myeloma disease showed in general very important abnormalities of circulating lipoproteins. Beside the presence of lipoprotein complexes with abnormal electrophoresis migration, we can observe either an hyperlipidemia associated with antilipoprotein auto-antibodies either, in contrary, an hypolipidemia. We studied 34 myeloma and one alpha heavy chain disease. In these subjects, all presenting clinical and biological myeloma tests but free of hepatic disease we evaluate after HDL separation their major lipid components: cholesterol and phospholipid. By electro immunodiffusion method we evaluate apolipoproteins A1 and B. We observe a decrease of Chol-HDL and PL-HDL in 51 p. cent of cases and a decrease of apo A1 in 80 p. cent of cases, this more marked in myeloma with gamma isotype. In contrary, apo B in all subjects studied remain normal. A correlation test with monoclonal immunoglobulin levels and its isotype is studied; the different parameters of monoclonal disease are discussed in relation with lipoprotein abnormalities.
Programming Heterogeneous Systems from an Image Processing DSL (2016)

Specialized image processing accelerators are necessary to deliver the performance and energy efficiency required by important applications in computer vision, computational photography, and augmented reality. But creating, "programming,"and integrating this hardware into a hardware/software system is difficult. We address this problem by extending the image processing language, Halide, so users can specify which portions of their applications should become hardware accelerators, and then we provide a compiler that uses this code to automatically create the accelerator along with the "glue" code needed for the user's application to access this hardware. Starting with Halide not only provides a very high-level functional description of the hardware, but also allows our compiler to generate the complete software program including the sequential part of the workload, which accesses the hardware for acceleration. Our system also provides high-level semantics to explore different mappings of applications to a heterogeneous system, with the added flexibility of being able to map at various throughput rates. We demonstrate our approach by mapping applications to a Xilinx Zynq system. Using its FPGA with two low-power ARM cores, our design achieves up to 6x higher performance and 8x lower energy compared to the quad-core ARM CPU on an NVIDIA Tegra K1, and 3.5x higher performance with 12x lower energy compared to the K1's 192-core GPU.
An XYZ Micromanipulator with three translational degrees of freedom (2006)

This paper introduces a three degree of freedom XYZ Micromanipulator (XYZM) that is fabricated in the $x$ - $y$ plane and positions components in the $x$ , $y$ , and $z$ directions using three independent linear inputs. The mechanism positions components on a platform using three legs, each composed of a slider mechanism and a parallelogram mechanism. Three versions of the XYZM were fabricated and tested using surface micromachining processes: the rigid-body, offset, and compliant XYZM. Slider displacements of 45 micrometers result in a predicted out-of-plane displacement of 188 micrometers for the rigid-body XYZM, 205 micrometers for the offset XYZM, and 262 micrometers for the compliant XYZM.
Lycopodiella inundata: insights into plant-fungal associations in early vascular plants (2017)

Recent studies have revealed that extant basal vascular plants associate with a wide range of Mucoromycotina and/or Glomeromycota fungi, paralleling the same in non-vascular liverworts and hornworts. This dispels the long-held paradigm that these early diverging lineages harbour Glomeromycota exclusively. Endophytes belonging to both fungal lineages have also been reported, for the first time, in a Devonian plant (Horneophyton ligneri). Together these discoveries point to much more diverse plant-fungus interactions in early vascular plants than previously assumed, however our understanding of these remains limited. In order to gain further insights into these key partnerships, especially those involving the early diverging Mucoromycotina, we are developing the lycophyte Lycopodiella inundata as an experimental system. L. inundata sporophytes have been shown to harbour solely Mucoromycotina fungi but equally fundamental, the identity of its gametophyte endophyte remains unknown. Using molecular and cytological approaches, we confirm that young L. inundata sporophytes are colonized exclusively by Mucoromycotina and show that the cytology of colonisation - consisting of both inter- and intracellular phases - closely resembles that in Haplomitriopsida liverwort-Mucoromycotina partnerships and the corm of H. ligneri. Our current isolation, resynthesis and molecular studies will provide further insights into both host and fungi specificity.
Three-dimensional optical diffusion tomography using iterative coordinate descent optimization (2001)

We demonstrate accurate and efficient three-dimensional optical diffusion imaging using simulated noisy data from a set of measurements at a single modulation frequency. A Bayesian framework provides for prior model conditioning, and a dual-step cost function optimization allows sequential estimation of the data noise variance and the image.
Experimental and quantum‐chemical studies of 1H, 13C and 15N NMR coordination shifts in Au(III), Pd(II) and Pt(II) chloride complexes with picolines (2008)

(1)H, (13)C and (15)N NMR studies of gold(III), palladium(II) and platinum(II) chloride complexes with picolines, [Au(PIC)Cl(3)], trans-[Pd(PIC)(2)Cl(2)], trans/cis-[Pt(PIC)(2)Cl(2)] and [Pt(PIC)(4)]Cl(2), were performed. After complexation, the (1)H and (13)C signals were shifted to higher frequency, whereas the (15)N ones to lower (by ca 80-110 ppm), with respect to the free ligands. The (15)N shielding phenomenon was enhanced in the series [Au(PIC)Cl(3)] < trans-[Pd(PIC)(2)Cl(2)] < cis-[Pt(PIC)(2)Cl(2)] < trans-[Pt(PIC)(2)Cl(2)]; it increased following the Pd(II) --> Pt(II) replacement, but decreased upon the trans --> cis-transition. Experimental (1)H, (13)C and (15)N NMR chemical shifts were compared to those quantum-chemically calculated by B3LYP/LanL2DZ + 6-31G**//B3LYP/LanL2DZ + 6-31G*.
Optimization of the Photon Path Length Probability Density Function-Simultaneous (PPDF-S) Method and Evaluation of CO2 Retrieval Performance Under Dense Aerosol Conditions (2019)

The photon path length probability density function-simultaneous (PPDF-S) algorithm is effective for retrieving column-averaged concentrations of carbon dioxide (XCO₂) and methane (XCH₄) from Greenhouse gases Observing Satellite (GOSAT) spectra in Short Wavelength InfraRed (SWIR). Using this method, light-path modification attributable to light reflection/scattering by atmospheric clouds/aerosols is represented by the modification of atmospheric transmittance according to PPDF parameters. We optimized PPDF parameters for a more accurate XCO₂ retrieval under aerosol dense conditions based on simulation studies for various aerosol types and surface albedos. We found a more appropriate value of PPDF parameters referring to the vertical profile of CO₂ concentration as a measure of a stable solution. The results show that the constraint condition of a PPDF parameter that represents the light reflectance effect by aerosols is sufficiently weak to affect XCO₂ adversely. By optimizing the constraint, it was possible to obtain a stable solution of XCO₂. The new optimization was applied to retrieval analysis of the GOSAT data measured in Western Siberia. First, we assumed clear sky conditions and retrieved XCO₂ from GOSAT data obtained near Yekaterinburg in the target area. The retrieved XCO₂ was validated through a comparison with ground-based Fourier Transform Spectrometer (FTS) measurements made at the Yekaterinburg observation site. The validation results showed that the retrieval accuracy was reasonable. Next, we applied the optimized method to dense aerosol conditions when biomass burning was active. The results demonstrated that optimization enabled retrieval, even under smoky conditions, and that the total number of retrieved data increased by about 70%. Furthermore, the results of the simulation studies and the GOSAT data analysis suggest that atmospheric aerosol types that affected CO₂ analysis are identifiable by the PPDF parameter value. We expect that we will be able to suggest a further improved algorithm after the atmospheric aerosol types are identified.
Slow Search (2015)

We live in a world where the pace of everything from communication to transportation is getting faster. In recent years a number of "slow movements" have emerged that advocate for reducing speed in exchange for increasing quality, including the slow food movement, slow parenting, slow travel, and even slow science. We propose the concept of "slow search," where search engines use additional time to provide a higher quality search experience than is possible given conventional time constraints. While additional time can be used to identify relevant results within the existing search engine framework, it can also be used to create new search artifacts and enable previously unimaginable user experiences. This talk will focus on how search engines can make use of additional time to employ a resource that is inherently slow: other people. Using crowdsourcing and friendsourcing, it will highlight opportunities for search systems to support new search experiences with high quality result content that takes time to identify.
Genome Differences between Treponema pallidum subsp. pallidum Strain Nichols and T. paraluiscuniculi Strain Cuniculi A (2007)

The genome of Treponema paraluiscuniculi strain Cuniculi A was compared to the genome of the syphilis spirochete Treponema pallidum subsp. pallidum strain Nichols using DNA microarray hybridization, whole-genome fingerprinting, and DNA sequencing. A DNA microarray of T. pallidum subsp. pallidum Nichols containing all 1,039 predicted open reading frame PCR products was used to identify deletions and major sequence changes in the Cuniculi A genome. Using these approaches, deletions, insertions, and prominent sequence changes were found in 38 gene homologs and six intergenic regions of the Cuniculi A genome when it was compared to the genome of T. pallidum subsp. pallidum Nichols. Most of the observed differences were localized in tpr loci and the vicinity of these loci. In addition, 14 other genes were found to contain frameshift mutations resulting in major changes in protein sequences. Analysis of restriction target sites representing 0.34% of the total genome length and DNA sequencing of three PCR products (0.46% of the total genome length) amplified from Cuniculi A chromosomal regions and comparison to the Nichols genome revealed a sequence similarity of 98.6 to 99.3%. These results are consistent with a close genetic relationship among the T. pallidum strains and subspecies and a strong, but relatively divergent connection between the human and rabbit pathogens.
Learning Assisted Identification of Scenarios Where Network Optimization Algorithms Under-Perform (2021)

We present a generative adversarial method that uses deep learning to identify network load traffic conditions in which network optimization algorithms under-perform other known algorithms: the Deep Convolutional Failure Generator (DCFG). The spatial distribution of network load presents challenges for network operators for tasks such as load balancing, in which a network optimizer attempts to maintain high quality communication while at the same time abiding capacity constraints. Testing a network optimizer for all possible load distributions is challenging if not impossible. We propose a novel method that searches for load situations where a target network optimization method underperforms baseline, which are key test cases that can be used for future refinement and performance optimization. By modeling a realistic network simulator&#x0027;s quality assessments with a deep network and, in parallel, optimizing a load generation network, our method efficiently searches the high dimensional space of load patterns and reliably finds cases in which a target network optimization method under-performs a baseline by a significant margin.
Breakable Hybrid Organosilica Nanocapsules for Protein Delivery (2015)

Abstract The direct delivery of specific proteins to live cells promises a tremendous impact for biological and medical applications, from therapeutics to genetic engineering. However, the process mostly involves tedious techniques and often requires extensive alteration of the protein itself. Herein we report a straightforward approach to encapsulate native proteins by using breakable organosilica matrices that disintegrate upon exposure to a chemical stimulus. The biomolecule‐containing capsules were tested for the intracellular delivery of highly cytotoxic proteins into C6 glioma cells. We demonstrate that the shell is broken, the release of the active proteins occurs, and therefore our hybrid architecture is a promising strategy to deliver fragile biomacromolecules into living organisms.
Quantitative measurement of single- and double-strand breakage of DNA in Escherichia coli by the antitumor antibiotics bleomycin and talisomycin (1985)

We developed an assay in which single-strand breakage (ssb) and double-strand breakage (dsb) of intracellular DNA by chemical agents can be accurately quantitated and differentiated. Escherichia coli cells containing plasmid pBR322 DNA were incubated with the antitumor antibiotics bleomycin A2 (BLM A2) or talisomycin A (TLM A). The plasmid DNA was isolated and then analyzed by electrophoresis on 1% agarose gels to separate the following conformational forms of plasmid DNA: (i) native, covalently closed, super helical, form I; (ii) nicked, relaxed circular, form II; and (iii) double-strand broken, linear, form III. Quantitation by densitometric analysis of the gels showed that BLM A2 and TLM A were equally active in terms of the concentrations of drug necessary to reduce equivalent amounts of form I DNA in the cells, whereas in vitro (using isolated pBR322 DNA as a drug substrate) twofold more TLM A than BLM A2 was required to produce an equivalent amount of reduction in form I DNA. TLM A produced more intracellular dsb than did BLM A2. The intracellular dsb activities (dsb/ssb ratio) measured from BLM A2 and TLM A were equivalent to those measured for the respective agents when isolated pBR322 DNA was used as the substrate. In E. coli both ssb and dsb were repaired, but TLM A damage was repaired more slowly and to a lesser extent, which may reflect the relative frequency of dsb.
Transforming Methyl Levulinate into Biosurfactants and Biolubricants by Chemoselective Reductive Etherification with Fatty Alcohols (2020)

Biomass-derived surfactants with very good surface tension and critical micellar concentration properties were obtained by conversion of methyl levulinate into methyl 4-alkoxypentanoates through reductive etherification with aliphatic alcohols. Among different bifunctional acid/metal catalysts best results were obtained with Pd on carbon bearing acid sites. The reaction occurred through the formation of an enol ether intermediate followed by hydrogenation. Pd in high-density planes was the active hydrogenation species, and an optimum crystal size was found to be approximately 10 nm. The reductive etherification with aliphatic alcohols was extended to other aliphatic and cyclic ketones and aldehydes obtained from biomass, and excellent results were obtained on supported Pd catalysts with the reaction route and experimental conditions described in this work.
Smad3 controls β‐1,3‐glucuronosyltransferase 1 expression in rat nucleus pulposus cells: Implications of dysregulated expression in disc disease (2012)

Our findings demonstrate that in healthy NP cells, the TGFβ-Smad3 axis serves as a regulator of GlcAT-1 expression. However, an altered responsiveness to TGFβ during disc degeneration may compromise GAG synthesis.
Population Differences in the Polyalanine Domain and 6 New Mutations in HLXB9 in Patients with Currarino Syndrome (2005)

Lack of HLXB9 mutations in some patients and the presence of variable phenotypes suggest DNA alterations in HLXB9 noncoding regions and/or in other genes encoding HLXB9 regulatory molecules or protein partners. If HLXB9, like other homeobox genes, has a threshold beyond which triplet expansions are pathologic, those populations enriched with larger alleles would be at a higher risk. The data illustrate the importance of ethnicity adjustment if these polymorphic markers are to be used in association studies.