gebhart/patrepeval huggingface dataset:
In search of cellular control: Signal transduction in context (1998)

The field of molecular cell biology has experienced enormous advances over the last century by reducing the complexity of living cells into simpler molecular components and binding interactions that are amenable to rigorous biochemical analysis. However, as our tools become more powerful, there is a tendency to define mechanisms by what we can measure. The field is currently dominated by efforts to identify the key molecules and sequences that mediate the function of critical receptors, signal transducers, and molecular switches. Unfortunately, these conventional experimental approaches ignore the importance of supramolecular control mechanisms that play a critical role in cellular regulation. Thus, the significance of individual molecular constituents cannot be fully understood when studied in isolation because their function may vary depending on their context within the structural complexity of the living cell. These higher-order regulatory mechanisms are based on the cell's use of a form of solid-state biochemistry in which molecular components that mediate biochemical processing and signal transduction are immobilized on insoluble cytoskeletal scaffolds in the cytoplasm and nucleus. Key to the understanding of this form of cellular regulation is the realization that chemistry is structure and hence, recognition of the importance of architecture and mechanics for signal integration and biochemical control. Recent work that has unified chemical and mechanical signaling pathways provides a glimpse of how this form of higher-order cellular control may function and where paths may lie in the future. J. Cell. Biochem. Suppls. 30/31:232–237, 1998. © 1998 Wiley-Liss, Inc.
Etching Effect on AC Powder EL Phosphor Brightness and Maintenance (1982)

The AC powder EL properties of the etched phosphor were investigated. The brightness obeyed the usual particle size effect. On the other hand, it was found that the maintenance was improved with decreasing the particle size by etching, opposed to the well‐known particle size effect. It is thought that the maintenance improvement by etching is attributed to activator, coactivator content effect, and to the effect that is caused by the removal of the phosphor's outer part.
Contemporary Percutaneous Treatment of Unprotected Left Main Coronary Stenoses (1997)

While results for selected patients appear promising, until early post-hospital discharge cardiac death can be better understood and minimized, percutaneous revascularization of ULMT stenosis should not be considered an alternative to bypass surgery for most patients. When percutaneous revascularization of ULMT is required, directional atherectomy and stenting appear to be the preferred techniques, and follow-up angiography 6 to 8 weeks after treatment is probably advisable.
Adaptive, real-time visual simultaneous localization and mapping (2009)

In this paper we present a real-time simultaneous localization and mapping system which uses a stereo camera as its only input. We combine the benefits of KLT feature tracking, which include high speed and robustness to repetitive features, with wide baseline features, which allow for feature matching after large camera motions. Updating the map of feature locations and camera poses is considerably more expensive than performing KLT tracking. For this reason we use the optical flow measured by the KLT tracker to adaptively select key frames for which we do a full map and camera pose update. In this way we limit the processing to only ¿interesting¿ parts of the video sequence. Additionally, we maintain a consistent scene scale at low cost by using a GPU implementation of multi-camera scene flow, a generalization of KLT to the motion of image features in three dimensions. The system uses multiple sub-maps; scalable, bag of features recognition and geometric verification to recover from motion estimation failure or ¿kidnapping¿. This architecture allows the robot to grow the existing map online and in real time while storing all of the data necessary for an off-line optimization to complete loops. We demonstrate the robustness of our system in a challenging indoor environment that includes semi-reflective glass walls and people moving in the scene.
Direct Time-Domain Observation of Attosecond Photoelectron Lifetimes and Attosecond Electron Dynamics in Occupied Bands in Solids (2016)

We use attosecond pulse trains to directly measure photoelectron lifetimes in Ni(111) and Cu(111). We observe a strong influence of material band structure on the measured lifetimes, which reveal attosecond timescale electron screening and scattering.
Subcriticality Measurement by Neutron Source Multiplication Method Swith a Fundamental Mode Extraction (2003)

A new neutron multiplication method has been proposed for an accurate measurement of subcriticality. The proposed method consists of two correction processes for (1) extraction of the fundamental mode from measuring data of a neutron detector that contains higher modes as well as the fundamental mode feeding from an external neutron source and (2) spatial corrections for perturbations induced by a reactivity addition in the distributions of the fundamental mode and a neutron importance field. Feasibility of the proposed method has been verified from a numerical study, although under some limitations such that the neutron multiplying system to be analyzed is small-sized and a reactivity change takes place homogeneously in a fuel loaded region. With extraction of the fundamental mode and the spatial corrections, the subcriticality can be estimated accurately even with measuring data highly contaminated with higher modes due to a detector position near to an external point neutron source. For a future application to measurement of control rod bank worth of a nuclear power plant from measuring data during a reactor physical testing, some useful guidelines have been obtained.
USE OF COAL DRYING TO REDUCE WATER CONSUMED IN PULVERIZED COAL POWER PLANTS (2005)

This is the eighth Quarterly Report for this project. The background and technical justification for the project are described, including potential benefits of reducing fuel moisture, prior to firing in a pulverized coal boiler. Analyses were performed to determine the effects of coal product moisture on unit performance. Results are given showing how the coal product moisture level affects parameters such as boiler efficiency, power required to drive the fluidizing air fan, other station service power needed for fans and pulverizers, net unit heat rate, thermal energy rejected by the cooling tower, and stack emissions.
Influence of the beam parameter product on fiber laser cut characteristics for highly reflective materials (2014)

Fiber lasers have been shown to be very effective at cutting highly reflective materials such as aluminum, brass and copper. The need for ever increasing processing speeds and excellent edge quality on thicker materials, which are dependent on the laser beam characteristics, constitute good reasons to investigate the influence of the beam parameter product (BPP) on the cut attributes. Laser cutting was carried out on various highly reflective material thicknesses for different BPP and focus spot sizes. Cutting speeds were recorded and the characteristic cut surfaces were quantified using a surface profiler. The outcome of the study on brass along with guidelines on optimum beam parameters for given material thicknesses is presented.
Weight of single and recurrent scattering in the reflection matrix of complex media (2022)

In a heterogeneous medium, the wave field can be decomposed as an infinite series known as the Born expansion. Each term of the Born expansion corresponds to a scattering order, it is thus theoretically possible to discriminate single and multiple scattering contribution to the field. Experimentally, what is actually measured is the total field in which all scattering orders interfere. Conventional imaging methods usually rely on the assumption that the multiple scattering contribution can be disregarded. In a back-scattering configuration, this assumption is valid for small depths, and begins to fail for depths larger than the scattering mean-free path ℓ_{s}. It is therefore a key issue to estimate the relative amount of single and multiple scattering in experimental data. To this end, a single-scattering estimator ρ[over ̂] computed from the reflection matrix has been introduced in order to assess the weight of single scattering in the backscattered wave field. In this paper, the meaning of this estimator is investigated and a particular attention is given to recurrent scattering. In a diffraction-limited experiment, a multiple scattering sequence is said to be recurrent if the first and last scattering events occur in the same resolution cell. Recurrent scattering is shown to be responsible for correlations between single scattering and higher scattering orders of the Born expansion, inducing a bias to the estimator ρ[over ̂] that should rather be termed confocal scattering ratio. Interestingly, a more robust estimator is built by projecting the reflection matrix in a focused basis. The argument is sustained by numerical simulations as well as ultrasonic data obtained around 1.5 MHz in a model medium made of nylon rods immersed in water. From a more general perspective, this work raises fundamental questions about the impact of recurrent scattering on wave imaging.
p21Cip1 modulates arterial wound repair through the stromal cell–derived factor-1/CXCR4 axis in mice (2008)

Cyclin-dependent kinase inhibitors, including p21Cip1, are implicated in cell turnover and are active players in cardiovascular wound repair. Here, we show that p21Cip1 orchestrates the complex interactions between local vascular and circulating immune cells during vascular wound repair. In response to femoral artery mechanical injury, mice with homozygous deletion of p21Cip1 displayed accelerated proliferation of VSMCs and increased immune cell infiltration. BM transplantation experiments indicated that local p21Cip1 plays a pivotal role in restraining excessive proliferation during vascular wound repair. Increased local vascular stromal cell-derived factor-1 (SDF-1) levels were observed after femoral artery injury in p21+/+ and p21-/- mice, although this was significantly greater in p21-/- animals. In addition, disruption of SDF-1/CXCR4 signaling inhibited the proliferative response during vascular remodeling in both p21+/+ and p21-/- mice. We provide evidence that the JAK/STAT signaling pathway is an important regulator of vascular SDF-1 levels and that p21Cip1 inhibits STAT3 binding to the STAT-binding site within the murine SDF-1 promoter. Collectively, these results suggest that p21Cip1 activity is essential for the regulation of cell proliferation and inflammation after arterial injury in local vascular cells and that the SDF-1/CXCR4 signaling system is a key mediator of vascular proliferation in response to injury.
Tissue engineering of human bladder (2011)

There are a number of conditions of the bladder that can lead to loss of function. Many of these require reconstructive procedures. However, current techniques may lead to a number of complications. Replacement of bladder tissues with functionally equivalent ones created in the laboratory could improve the outcome of reconstructive surgery. A review of the literature was conducted using PubMed to identify studies that provide evidence that tissue engineering techniques may be useful in the development of alternatives to current methods of bladder reconstruction. A number of animal studies and several clinical experiences show that it is possible to reconstruct the bladder using tissues and neo-organs produced in the laboratory. Materials that could be used to create functionally equivalent urologic tissues in the laboratory, especially non-autologous cells that have the potential to reject have many technical limitations. Current research suggests that the use of biomaterial-based, bladder-shaped scaffolds seeded with autologous urothelial and smooth muscle cells is currently the best option for bladder tissue engineering. Further research to develop novel biomaterials and cell sources, as well as information gained from developmental biology, signal transduction studies and studies of the wound healing response would be beneficial.
A Single Heparin Binding Region within the Fibrinogen-like Domain Is Functional in Chick Tenascin-C (1995)

Tenascin-C binds to cell surface and matrix proteoglycans and to heparin. Two heparin binding regions have recently been localized per tenascin-C monomer, one in the C-terminal fibrinogen-like domain and the other in fibronectin type III repeats 3-5. Here we show that a single region in each subunit is necessary and sufficient for heparin binding by whole tenascin-C at physiological ionic strength. First, native tenascin-C was bound to heparin-agarose and digested with Pronase. A 29-kDa fragment retained on the heparin column was recognized by a monoclonal antibody against the fibrinogen-like domain. In contrast, small fragments labeled by an antibody against fibronectin type III repeats 2-5 were released. Second, mild tryptic digestion of tenascin-C yielded two related fragments of 180 and 170 kDa. The latter missed part of the fibrinogen domain and had lost affinity for heparin, in contrast to the former. Finally, chick tenascin-C constructs were recombinantly expressed in human cells. Whereas the complete protein and a mutant lacking fibronectin type III repeats 1-5 bound to heparin-agarose, recombinant tenascin-C missing the C-terminal fibrinogen-like globe did not. Thus, whole chick tenascin-C contains one essential heparin binding region per subunit, located in the fibrinogen-like domain within 10 kDa from the C terminus.
Self-Assembly and Critical Aggregation Concentration Measurements of ABA Triblock Copolymers with Varying B Block Types: Model Development, Prediction, and Validation (2016)

The dissipative particle dynamics (DPD) simulation technique is a coarse-grained (CG) molecular dynamics-based approach that can effectively capture the hydrodynamics of complex systems while retaining essential information about the structural properties of the molecular species. An advantageous feature of DPD is that it utilizes soft repulsive interactions between the beads, which are CG representation of groups of atoms or molecules. In this study, we used the DPD simulation technique to study the aggregation characteristics of ABA triblock copolymers in aqueous medium. Pluronic polymers (PEG-PPO-PEG) were modeled as two segments of hydrophilic beads and one segment of hydrophobic beads. Tyrosine-derived PEG5K-b-oligo(desaminotyrosyl tyrosine octyl ester-suberate)-b-PEG5K (PEG5K-oligo(DTO-SA)-PEG5K) block copolymers possess alternate rigid and flexible components along the hydrophobic oligo(DTO-SA) chain, and were modeled as two segments of hydrophilic beads and one segment of hydrophobic, alternate soft and hard beads. The formation, structure, and morphology of the initial aggregation of the polymer molecules in aqueous medium were investigated by following the aggregation dynamics. The dimensions of the aggregates predicted by the computational approach were in good agreement with corresponding results from experiments, for the Pluronic and PEG5K-oligo(DTO-SA)-PEG5K block copolymers. In addition, DPD simulations were utilized to determine the critical aggregation concentration (CAC), which was compared with corresponding results from an experimental approach. For Pluronic polymers F68, F88, F108, and F127, the computational results agreed well with experimental measurements of the CAC measurements. For PEG5K-b-oligo(DTO-SA)-b-PEG5K block polymers, the complexity in polymer structure made it difficult to directly determine their CAC values via the CG scheme. Therefore, we determined CAC values of a series of triblock copolymers with 3-8 DTO-SA units using DPD simulations, and used these results to predict the CAC values of triblock copolymers with higher molecular weights by extrapolation. In parallel, a PEG5K-b-oligo(DTO-SA)-b-PEG5K block copolymer was synthesized, and the CAC value was determined experimentally using the pyrene method. The experimental CAC value agreed well with the CAC value predicted by simulation. These results validate our CG models, and demonstrate an avenue to simulate and predict aggregation characteristics of ABA amphiphilic triblock copolymers with complex structures.
Mithramycin A Improves Functional Recovery by Inhibiting BSCB Disruption and Hemorrhage after Spinal Cord Injury (2017)

After spinal cord injury (SCI), blood-spinal cord barrier (BSCB) disruption and progressive hemorrhage lead to secondary injury, subsequent apoptosis and/or necrosis of neurons and glia, causing permanent neurological deficits. Growing evidence indicates that mithramycin A (MA), an anti-cancer drug, has neuroprotective effects in ischemic brain injury and Huntington's disease (HD). However, the precise mechanism underlying its protective effects is largely unknown. Here, we examined the effect of MA on BSCB breakdown and hemorrhage as well as subsequent inflammation after SCI. After moderate spinal cord contusion injury at T9, MA (150 μg/kg) was immediately injected intraperitoneally (i.p.) and further injected once a day for 5 days. Our data show that MA attenuated BSCB disruption and hemorrhage, and inhibited the infiltration of neutrophils and macrophages after SCI. Consistent with these findings, the expression of inflammatory mediators was significantly alleviated by MA. MA also inhibited the expression and activation of matrix metalloprotease-9 (MMP-9) after injury, which is known to disrupt BSCB and the degradation of tight junction (TJ) proteins. In addition, the expression of sulfonylurea receptor 1 (SUR1) and transient receptor potential melastatin 4 (TRPM4), which are known to mediate hemorrhage at an early stage after SCI, was significantly blocked by MA treatment. Finally, MA inhibited apoptotic cell death and improved functional recovery after injury. Thus, our results demonstrated that MA improves functional recovery by attenuating BSCB disruption and hemorrhage through the downregulation of SUR1/TRPM4 and MMP-9 after SCI.
Temperature-aware floorplanning of microarchitecture blocks with IPC-power dependence modeling and transient analysis (2006)

Operating temperatures have become an important concern in high performance microprocessors. Floorplanning or block-level placement offers excellent potential for thermal optimization through better heat spreading between the blocks, but these optimizations can also impact the throughput of a microarchitecture, measured in terms of the number of instructions per cycle (IPC). In nanometer technologies, global buses can have multicycle delays that depend on the positions of the blocks, and it is important for a floorplanner to be microarchitecturally-aware to be sure that thermal and IPC considerations are appropriately balanced. This paper proposes a methodology for thermally-aware microarchitecture floorplanning. The approach models the interactions between the IPC and the temperature distribution, and incorporates both factors in the floorplanning cost function. Our approach uses transient modeling and optimizes both the peak and the average temperatures, and employs a design of experiments (DOE) based strategy, which effectively captures the huge exponential search space with a small number of cycle-accurate simulations. A comparison with a technique based on previous work indicates that the proposed approach results in good reductions both in the average and the peak temperatures for a range of SPEC benchmarks.
Quality of life and symptoms among patients with relapsed/refractory AL amyloidosis treated with ixazomib‐dexamethasone versus physician's choice (2023)

Patient-reported outcomes in AL amyloidosis have not been well-studied. We analyzed health-related quality of life (HRQOL) and AL amyloidosis symptoms data from the phase 3 TOURMALINE-AL1 trial (NCT01659658) (ixazomib-dexamethasone, n = 85; physician's choice of chemotherapy [PC], n = 83). HRQOL and symptom burden were measured with the SF-36v2, Functional Assessment of Cancer Therapy/Gynecologic Oncology Group Neurotoxicity subscale (FACT/GOG-Ntx), and an amyloidosis symptom questionnaire (ASQ). Score changes during treatment were analyzed descriptively and using repeated-measures linear mixed models; analyses were not adjusted for multiplicity. Least-squares (LS) mean changes from baseline were significantly higher (better HRQOL) for ixazomib-dexamethasone at several cycles for SF-36v2 Role Physical and Vitality subscales (p < .05); no subscales demonstrated significant differences favoring PC. For FACT/GOG-Ntx, small but significant differences in LS mean changes favored ixazomib-dexamethasone over PC at multiple cycles for seven items and both summary scores; significant differences favored PC for one item (trouble hearing) at multiple cycles. ASQ total score trended downward (lower burden) in both arms; significant LS mean differences favored ixazomib-dexamethasone over PC at some cycles (p < .05). Patients with relapsed/refractory AL amyloidosis treated with ixazomib-dexamethasone experienced HRQOL and symptoms that were similar to or trended better than patients treated with PC despite longer duration of therapy.
EVIDENCE FOR THE MECHANISM OF THE LYTIC ACTION OF PHALLOLYSIN ON ERYTHROCYTES AND LIPOSOMES (1981)

Conference Abstract| April 01 1981 EVIDENCE FOR THE MECHANISM OF THE LYTIC ACTION OF PHALLOLYSIN ON ERYTHROCYTES AND LIPOSOMES H.-J. Bühring; H.-J. Bühring 1Max-Planck-Institut für med. Forschung, Abt. N.-Chemie, 6900 Heidelberg-1, B.R.D. Search for other works by this author on: This Site PubMed Google Scholar A.C. Vaisius; A.C. Vaisius 1Max-Planck-Institut für med. Forschung, Abt. N.-Chemie, 6900 Heidelberg-1, B.R.D. Search for other works by this author on: This Site PubMed Google Scholar H Faulstich H Faulstich 1Max-Planck-Institut für med. Forschung, Abt. N.-Chemie, 6900 Heidelberg-1, B.R.D. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1981) 9 (2): 313P. https://doi.org/10.1042/bst009313p Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share MailTo Twitter LinkedIn Cite Icon Cite Get Permissions Citation H.-J. Bühring, A.C. Vaisius, H Faulstich; EVIDENCE FOR THE MECHANISM OF THE LYTIC ACTION OF PHALLOLYSIN ON ERYTHROCYTES AND LIPOSOMES. Biochem Soc Trans 1 April 1981; 9 (2): 313P. doi: https://doi.org/10.1042/bst009313p Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1981 Biochemical Society1981 Article PDF first page preview Close Modal You do not currently have access to this content.
Digitally designed holographic optical element for light field displays (2018)

Concave micro-mirror arrays fabricated as holographic optical elements are used in projector-based light field displays due to their see-through characteristics. The optical axes of each micro-mirror in the array are usually made parallel to each other, which simplifies the fabrication, integral image rendering, and calibration process. However, this demands that the beam from the projector be collimated and made parallel to the optical axis of each elemental micro-mirror. This requires additional collimation optics, which puts serious limitations on the size of the display. In this Letter, we propose a solution to the above issue by introducing a new method to fabricate holographic concave micro-mirror array sheets and explain how they work in detail. 3D light field reconstructions of the size 20 cm×10 cm and 6 cm in depth are achieved using a conventional projector without any collimation optics.