gebhart/patrepeval huggingface dataset:
Subnetwork-based prognostic biomarkers exhibit performance and robustness superior to gene-based biomarkers in breast cancer (2018)

Abstract Background Effective classification of cancer patients into groups with differential survival remains an important and unsolved challenge. Biomarkers have been developed based on mRNA abundance data, but their replicability and clinical utility is modest. Integrating functional information, such as pathway data, has been suggested to improve biomarker performance. To date, however, the advantages of subnetwork-based biomarkers have not been quantified. Results We deeply sampled the population of prognostic gene-based and subnetwork-based biomarkers in a breast cancer meta-dataset of 4,960 patients. Analysing the performance and robustness of 22,000,000 gene biomarkers and 6,250,000 subnetwork biomarkers across twenty different training:testing cohort partitions of the meta-dataset revealed that subnetwork biomarkers exhibit superior overall performance and higher concordance across partitions. We find evidence of an upper bound for optimal biomarker size of ∼200 genes or ∼100 subnetworks. Additionally, with both biomarker feature types, larger biomarkers tend to show less consistency in performance across partitions, suggestive of over-fitting. Finally, an evaluation of varying training cohort sizes quantifies the effects of training cohort size. Conclusions Many groups are developing techniques for exploiting network-based representations of biological pathways to characterize cancer and other diseases. By considering the distribution of gene- and subnetwork-based biomarkers, we show that pathway data improves performance and replicability, and that smaller biomarkers are more robust across patient cohorts. These insights may facilitate development of clinically useful biomarkers.
Biomarking Trait Resilience With Salivary Cortisol in Chinese Undergraduates (2020)

This study aimed to examine the relationship between trait resilience and salivary cortisol in a group of Chinese undergraduates. The Chinese versions of the Brief Resilience Scale and a measure of optimism, the revised Life Orientation Test were administered to 49 Chinese undergraduates who provided self-collected saliva samples six times per day (immediately after waking; 0.5, 3, 6, and 12 h thereafter; and at bedtime) over 3 consecutive weekdays. The cortisol data were aggregated across the 3 days to examine the association between resilience and components of the diurnal rhythm of cortisol using multiple regression. The results showed that higher resilience was associated with a stronger cortisol response to awakening and a steeper diurnal decline in cortisol from waking to bedtime. Resilience was positively associated with cortisol output over the course of the day but this relationship was not significant (<i>p</i> = 0.065). This pattern of diurnal rhythm is consistent with that typically observed in better adjusted individuals. Generated by an intensive protocol with compliance objectively monitored, these findings clearly indicate the important role of the hypothalamic-pituitary-adrenocortical axis in health and adjustment and contribute to the growing literature on resilience and cortisol in humans.
Effect of Heat Pretreatment on the Yield and Composition of Oil Extracted from Corn Fiber (1999)

Previously, hexane extraction of corn fiber was reported to produce a unique and potentially valuable oil that contained high levels of several phytosterols (which have been noted for their cholesterol-lowering properties). Current studies revealed that heat treatment (over the range of 100-175 degrees C) of corn fiber in either a convection oven or a vacuum oven caused only a modest reduction in the levels of the phytosterol components. However, these same heat pretreatments caused a considerable increase (up to 10-fold) in the levels (increasing from 0.34 wt % to a maximum of 3.64 wt % gamma-tocopherol in the oil) and yields (increasing from 5.4 mg of gamma-tocopherol/100 g of corn fiber to a maximum of 52.1 mg of gamma-tocopherol/100 g of corn fiber) of gamma-tocopherol in corn fiber oil. The main differences between the convection oven and vacuum oven pretreatments were associated with the disappearance of free fatty acids and free phytosterols at the higher temperature pretreatments in the vacuum oven, probably due to the lower boiling points of these lipids. Microwave pretreatment was also effective but caused a much smaller increase in the levels of gamma-tocopherol.
Determination of Antioxidants in Oil Palm Leaves (Elaeis guineensis) (2010)

Problem statement: Previous findings on the occurrence of water soluble antioxidants in palm oil has brought to the question on whether these compounds is also present in other parts of the oil palm; namely its leaves. Approach: It is now believed that the water soluble antioxidants are also present in other biomass of the oil palm, namely, the leaves. This study reported on the determination of the water soluble antioxidants in oil palm leaves. Results: The results showed the analyses of the antioxidants in oil palm leaves. Conclusion: This study is thus conducted to trace the availability of these antioxidants in the leaves of the oil palm of the Elaeis guineensis variety.
Lewis Acid-Catalyzed Synthesis of Aziridines (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTLewis Acid-Catalyzed Synthesis of AziridinesLuis Casarrubios, Julio A. Pérez, Maurice Brookhart, and Joseph L. TempletonView Author Information Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 Cite this: J. Org. Chem. 1996, 61, 24, 8358–8359Publication Date (Web):November 29, 1996Publication History Received23 July 1996Revised17 September 1996Published online29 November 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jo961391whttps://doi.org/10.1021/jo961391wrapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views3412Altmetric-Citations153LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Aziridines,Carbene compounds,Ethyl groups,Lewis acids,Solvents Get e-Alerts
Hérnia medular idiopática atípica — relato de caso (2018)

Resumo A hérnia medular idiopática (HMI) é uma causa rara de mielopatia progressiva que afeta principalmente mulheres de meia idade com apresentação clínica típica com a Síndrome de Brown-Sequard. Possui etiologia incerta, sendo a teoria mais aceita a de ser um defeito congênito na dura-máter que leva a uma herniação lenta e progressiva da medula que ocasiona uma lesão evolutiva, podendo levar a um déficit irreversível quando subdiagnosticado e não tratado da forma ideal. A realização da ressonância magnética é fundamental para o diagnóstico, e a cirurgia é o tratamento de escolha para reverter e cessar os sintomas mielopáticos. O presente artigo mostra um caso de uma apresentação atípica da localização do defeito dural e da herniação, não descrita ainda na literatura, levando a uma apresentação neurológica e anatômica incomum para esta patologia, obrigando a realizar um planejamento cirúrgico específico para tal caso.
ChemInform Abstract: Patterned Deposition of Copper on Poly(tetrafluoroethylene) (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Taxol Semisynthesis:  A Highly Enantio- and Diastereoselective Synthesis of the Side Chain and a New Method for Ester Formation at C-13 Using Thioesters (1997)

A very simple, new, and straightforward approach to the Paclitaxel (Taxol) and Docetaxel (Taxotere) side chains has been developed using the imine addition reaction of thioester-derived boron enolates bearing chiral ligands. The addition reaction was studied extensively, using a combination of different thioesters (ROCH2COSPh, ROCH2COSt-Bu), oxygen protecting groups (R = Bn, TBDMS, COPh, EE, TMS), chiral boron ligands [derived from both (−) and (+)-menthone], imines (PhCHNSiMe3, PhCHNCOPh), and in the presence or in the absence of additional Lewis acids (BF3−OEt2, Et2AlCl, TiCl4). The side chain was assembled in a few steps with the correct relative (syn) and absolute stereochemistry (2R,3S). The stereochemical outcome of the boron-mediated reaction was rationalized using chair vs boat transition state structures. A new direct route for attachment of the side chains to the baccatin nucleus using thioester chemistry has also been developed. By treatment of a mixture of a thioester (8, 12, or 17) and protected baccatin III (2b, 2c) with LHMDS, the 13-O acylated compounds were obtained in high yield (up to 90%). Hydrolysis of 18b gave Paclitaxel (1a) in 80% yield.
IL-2-based immunotherapy alters circulating neutrophil Fc receptor expression and chemotaxis. (1990)

We performed functional assays on polymorphonuclear (PMN) leukocytes from 21 patients with advanced cancers, before, during, and after IL-2 administration. Of these, 19 were treated with high dose bolus IL-2 infusions (10(5) U/kg every 8 h) and 2 patients received low dose continuous infusions of IL-2 (250 U/kg/h). Five of six patients studied after IL-2 therapy had a decrease in their PMN chemotactic response to FMLP after bolus IL-2 (mean 8 doses) or, after the 4th day of continuous infusion IL-2 (pre-IL-2 values of 82% +/- 17% to 45% +/- 1% post-IL-2, p2 less than 0.004) compared with normal control values. In 8 of 10 patients studied, PMN capacity to oxidize intracellular dichlorofluorescein dye, an indirect measurement of O2- production in response to PMA stimulation, decreased after IL-2 administration (pre-IL-2 mean dichlorofluorescein oxidation (by channel number) 243 +/- 128 vs 3-day post-IL-2 87 +/- 86, p2 less than 0.02). Furthermore, a marked decrease in Fc gamma R III (Leu-11, CD16) expression was observed in 12/13 patients' PMN studied after IL-2 therapy (mean percent of PMN population with positive FcR expression was 81.1 +/- 15.4% pre-IL-2 which decreased to 56.0 +/- 30.5% post-IL-2, p2 less than 0.001). Other PMN surface markers (My4, My7, ICAM-1, LFA1, LFA3, Mac1) did not change significantly. PMN-mediated antibody-dependent cellular cytotoxicity did not change after IL-2 therapy (only 4/15 patients demonstrated more than 50% reduction in antibody-dependent cellular cytotoxicity). PMN phagocytosis of Staphylococcus aureus was also not significantly altered by IL-2 administration in six patients studied (pre-IL-2, 99 +/- 17% vs 111 +/- 28% post-IL-2, p2 greater than 0.2). We conclude that the systemic administration of IL-2 by intermittent or continuous administration is associated with marked changes in PMN function and cell surface receptor expression. These alterations may contribute to the apparent increased susceptibility to bacterial infection observed in these patients.
High-contrast quantum-confined Stark effect in Ge/SiGe quantum well stacks on Si with ultra-thin buffer layers (2018)

Quantum-confined Stark effect with a record absorption contrast of 2.5 for 1V swing is demonstrated in Ge/GeSi quantum well stacks grown on Si using ultra-thin buffer layers, targeting future integration in a silicon photonics platform.
Space-time autocoding: arbitrarily reliable communication in a single fading interval (2002)

Prior treatments of space-time communications in Rayleigh flat fading generally assume that channel coding covers either one fading interval-in which case there is a nonzero "outage capacity"-or multiple fading intervals-in which case there is a nonzero Shannon capacity. However, we establish conditions under which channel codes span only one fading interval and yet are arbitrarily reliable. In short, space-time signals are their own channel codes. We call this phenomenon space-time autocoding, and the accompanying capacity the space-time autocapacity.
High SVR12 rates with combination of NS5A- and NS5B- inhibitors for 24 weeks in liver transplanted patients (2017)

HCV recurrence after liver transplantation markedly impacts graft and patient survival. DAA therapy provides improved SVR12 rates in former difficult to treat patients, however experience in liver transplanted patients with HCV reinfection still is limited. In the context of organ shortage efficient HCV therapies are essential to prevent transplant loss and preserve organ function.
Some Parametric Solutions to the Navier-Lame Equation in Cylindrical Coordinates Using Buchwald Displacement Potentials (2017)

Using a separable Buchwald representation in cylindrical coordinates, we show how under certain conditions the coupled equations of motion governing the Buchwald potentials can be decoupled and then solved using well-known techniques from the theory of PDEs. Under these conditions, we then construct several parametrized families of particular solutions to the Navier-Lame equation. In this paper, we specifically construct solutions having 2pi-periodic angular parts. Our method of solving the governing equations of motion is much more general than the conventional cylindrical-wave substitution method that is ubiquitous in the literature and has the capacity to be further generalized. As an application, we demonstrate how the obtained parametric solutions can be used to efficiently construct exact solutions to certain types of forced-vibration problems. In particular, we consider the forced response of a solid elastic cylinder subjected to a time-harmonic surface pressure that varies sinusoidally along its axis. We also briefly consider applications to some forced-relaxation type problems.
Supplementary Figures 1-2 from PlGF/VEGFR-1 Signaling Promotes Macrophage Polarization and Accelerated Tumor Progression in Obesity (2023)

&lt;p&gt;Supplementary Figure 1 - A) Vessel density in PAN02 tumors from lean and obese mice, and effect of VEGFR-1-TK-deletion on tumor vessel density and hypoxia markers in obese mice. Supplementary Figure 2 - Gene expression of M1 / M2 markers in TAMs isolated from PAN02 tumors in lean and obese mice.&lt;/p&gt;
Treatment of vernal keratoconjunctivitis a double-masked study (1993)

Thirty-one children aged five to 14 years with severe vernal keratoconjunctivitis (VKC) were enrolled in a double-masked study evaluating the efficacy of three ophthalmic preparations: cromolyn sodium (Opticrom) 2%, artificial tears and fluorometholone 0.1% (FML). These drugs were coded respectively as A, B, C, and dispensed in similar bottles. Both eyes were treated, and drug assignment was made at random. Objective assessment of the disease activity was done under slit lamp by two ophthalmologists according to a five-point scale. The results were tabulated and the chi-square test performed. Decoding of the drugs was done only after completion of the statistical analysis. FML was found effective with a statistically significant difference from the other two drugs, both after the first week on the initially assigned treatment (p = 0.05) and on completion of the treatment period according to protocol (p = 0.005). Although several patients improved under cromolyn sodium, there was no statistically significant difference between cromolyn sodium 2% and artificial tears. All the preparations were well tolerated. One patient developed bilateral allergic blepharitis when treated with FML during the study. Another patient who responded well to FML developed posterior subcapsular cataract while continuing treatment with corticosteroids a few months after completion of the study.
Limited genetic control of specific IgE responses to rye grass pollen allergens in Australian twins (1998)

Evidence for genetic control of allergen-specific IgE responses in a large population sample of twins to individual ryegrass allergens is limited, indicating that the IgE responses to specific ryegrass pollen allergens are determined largely by environmental factors.
High energy hybrid fiber - YB:SFAP laser with dynamic spectral and temporal pulse shaping (2008)

We have commissioned a turnkey 500 mJ, 10 Hz front end laser. The system delivers temporally and spectrally tailored pulses to correct signal distortions within itself or subsequent amplifiers from single longitudinal mode to 250 GHz RF bandwidth.
A Method to Suppress High Peaks in BPSK-Modulated OFDM Signal (2004)

We address the problem of classification of binary phase-shift keying-modulated multicarrier signals with the peak-to-average power ratio (PAPR) exceeding 3/4 of the maximal possible value. By providing a simple characterization of such signals, we derive an upper bound on their number, and propose a simple sufficient condition for the signals to have low PAPR. Based on this, we describe a simple method for generation of signals with guaranteed PAPR gain of more than 2.5 dB using only two redundant tones.
Characterization of Spin-Coated Terbium-Doped Strontium Cerate Thin Film Membranes (2008)

In this article we present the synthesis and characterization of thin film membranes based on a ceramic oxide system with a perovskite structure, which is of interest in the development of solid oxide fuel cells (SOFCs) and hydrogen (H2) separation membranes. Continuous and homogenous dense thin film membranes of terbium-doped strontium cerate (SrCe0.95Tb0.05O3-δ) have been prepared from ethylene glycol-based polymeric precursors using spin-coating technique. The Polymeric precursors have been deposited on silicone-based substrates and converted to dense polycrystalline metal oxide films after a sequence of annealing treatment at relatively low temperatures (400°C). Fourier transform infrared spectroscopy (FTIR) and x-ray diffraction (XRD) techniques are used to characterize the polymeric precursor chemistry and to confirm the perovskite structure of the calcined thin films respectively. The effect of sintering temperature and number of spin-coating cycles on the surface morphology and film thickness of the calcined thin films have been studied systematically using scanning electron microscopy (SEM) and focused ion-beam (FIB) milling techniques respectively. The surface chemistry of the thin membranes has been revealed using the x-ray photoelectron spectroscopy (XPS) analysis. FIB cross-section images indicate that thin membrane films having varying thicknesses within the range of 200 nm-2 μm can be effectively produced by controlling the number of spin-coating cycle combined with the proper drying and annealing cycles after each individual coating-step.
Predictors of Hemodynamic Improvement and Stabilization Following Intraaortic Balloon Pump Implantation in Patients With Advanced Heart Failure. (2018)

Elevated CVP and lower HR and PCWP before IABP initiation help predict high response to IABP.
An Image Sensor using Photoleakage Current and Feedthrough Voltage of Amorphous Si Thin-film Transistors (2008)

A flat panel image sensor with a simple structure, which contains only one a-Si:H TFT and a storage capacitor in each pixel, has been proposed. Instead of utilizing external voltage supply, a feedthrough voltage caused by parasitic capacitance of TFT was applied to extract the photogenerated charges in a-Si:H thin film. Decrease of feedthrough voltage owing to the photoleakage current during the transient time caused by gate pulse distortion was estimated to be less than 10%. A 3.8-inch prototype image sensor was fabricated, and sensor operation with 3-4bit still and motion image was successfully obtained. The possibility of high-aperture-ratio LCD with embedded image sensor has been shown.
Low-code experimentation on software products (2022)

The continuous development of software products can be supported by systematically testing different software variants with the users. During this so-called continuous experimentation, different variants are presented to dedicated user groups, and the results are compared to determine the better-performing one. However, the product owner often defines those experiments while the software developers do their implementation. This, in turn, results in additional communication and synchronization effort. To bridge the gap between the definition and implementation of experiments, we provide a solution based on low-code development. Low-code development, in turn, allows the development of software products by non-developers using a graphical user interface (GUI). Within our solution, the product owner can model the experiments, product variants, and user groups within a GUI. Code wrappers are generated from those models, which the software developers can modify. Last, those variants are executed by different users, and the results are visualized for the product owner. This workshop paper shows the technical feasibility based on a streaming application.
Understanding the backward slices of performance degrading instructions (2000)

For many applications, branch mispredictions and cache misses limit a processor's performance to a level well below its peak instruction throughput. A small fraction of static instructions, whose behavior cannot be anticipated using current branch predictors and caches, contribute a large fraction of such performance degrading events. This paper analyzes the dynamic instruction stream leading up to these performance degrading instructions to identify the operations necessary to execute them early. The backward slice (the subset of the program that relates to the instruction) of these performance degrading instructions, i f small compared to the whole dynamic instruction stream, can be pre-executed to hide the instruction's latency. To overcome conservative dependence assumptions that result in large slices, speculation can be used, resulting in speculative slices. This paper provides an initial characterization of the backward slices of L2 data cache misses and branch mispredictions, andshows the effectiveness of techniques, including memory dependence prediction and control independence, for reducing the size of these slices.Through the use of these techniques, many slices can be reduced to less than one tenth of the full dynamic instruction stream when considering the 512 instructions before the performance degrading instruction.
Switching characteristics of SiC-VJFET and manufacture of inverter (2010)

The superior properties of silicon carbide (SiC) power electronic devices compared with silicon (Si) are expected to have a significant impact on next-generation vehicles. When super high-speed switching devises such as SiC-VJFET are operated in a power converter, their high dv/dt rate in the rise time and the fall time causes a high-frequency common-mode current. It is necessary to evaluate the EMI by high-speed switching devises such as SiC-VJFET for designing a 3 phase inverter with SiC-VJFET. This paper describes switching characteristics such as rise time, fall time and switching loss of SiC-VJFET. We also report manufacture of inverter using SiC-VJFET devices and an electric vehicle installing ac servo-motor driven by the SiC-VJFET inverter.