gebhart/patrepeval huggingface dataset:
Expression of The αβ T‐Cell Receptor Is Necessary for The Generation of The Thymic Medulla (1993)

The architecture of the thymus of mice that congenitally fail to express the alpha beta T-cell receptor (TCR alpha beta) has been examined by immunohistology. In these mice, a defined mutation was introduced into the TCR alpha gene by homologous recombination. By using antibodies specific for cortical or medullary epithelium and for major histocompatibility complex antigens, the network of cortical epithelium in these mice was shown to be essentially unaltered in comparison with that of normal mice. In contrast, the thymic medulla was considerably reduced in size. This analysis shows that expression of the alpha beta TCR but not the gamma delta TCR is obligatory for establishing the thymic medulla and suggests that the growth of medullary epithelial cells may require contact with TCR alpha beta-expressing cells.
Implantable vs Prolonged External Electrocardiographic Monitoring for Atrial Fibrillation Detection in Patients With Ischemic Stroke—Reply (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Charge contribution to patch-charged microparticle adhesion (2014)

Microparticle adhesion influenced by electrostatic charge has been a significant research interest for over past three decades or so in a wide spectrum of areas of interest from manufacturing (electrophotography, powder technology, metallurgy, and semi-conductor manufacturing) to natural phenomena (desert sandstorms and northern lights (auroras)). However, over the years, as a result of the strong discrepancies between the experimental adhesion measurements data and theoretical predictions, some key issues regarding the contributors of adhesion forces in charged microparticles and the nature of surface charge distribution still remain unresolved. In the current work, a non-contact ultrasonic approach is presented and employed for understanding the nature of charge distribution on a single microparticle and determining the effect of electrostatic charge on its adhesion in a non-invasive manner. From the vibrational spectra of the charged particle response to the ultrasonic substrate oscillations under various electrostatic loading conditions, three distinct shifting patterns of vibrational (rocking) resonance frequencies are observed for each level of applied substrate surface voltage, implying an un-symmetric force field on the particle, thus depicting non-uniform non-symmetric surface charge distribution on its surface. Also, a simple mathematical model was presented and employed for predicting the equivalent bulk charge on a single microparticle (toner) from resonance frequency shifts. In summary, it is found that the charge levels reported here are consistent with the previously published data, and it is demonstrated that, in a non-invasive manner, non-uniform charge distribution on a single microparticle can be observed and its total charge can be predicted.
Stability of LiNi0.5Mn1.5O4 in 1.2M 3:7 EC/EMC Electrolyte Solution (2013)

Abstract not Available.
‘The largest and widest Church ever established’ (2015)

Abstract This chapter focuses on the influence Baptist George Dawson, who established his own church in Birmingham in 1847 — the Church of the Saviour — from which to preach his message that Christian charity is more important than Evangelical orthodoxy, and that it is a Christian's duty to engage in politics. Both his religious and his political affinities were with the Unitarians, and especially with the intuitive school of James Martineau.
Dynamics of the reaction of N+ with H2. IV. Reactive scattering at relative energies above 6 eV (1976)

Product velocity vector distributions for the reaction N+(H2,H)NH+ and its isotopic variants have been determined in the range of relative energies above 6 eV. The reaction is direct, and there is a critical relative energy above which the spectator stripping peak disappears and is replaced by a double intensity lobe structure. Some evidence of the reaction of electronically excited metastable ions, probably N+(1D), is found. The results are compared with the predictions of the sequential impulse model of reactive scattering. The agreement is generally good, except that more very large angle scattering is observed, particularly for the N+(HD,H)ND+ case, than is predicted by the model.
Is the sensitivity of cells for FGF-1 and FGF-2 regulated by cell surface heparan sulfate proteoglycans? (1997)

We have examined the importance of cell surface heparan sulfate proteoglycans (HSPG) in fibroblast growth factor (FGF) signaling. 3T3 cells grown under conventional conditions were much more sensitive to FGF-2 compared to FGF-1. However, cells were equally sensitive to FGF-1 and FGF-2 using conditions which reduced the effect of endogenous HSPG. Addition of heparin, or treatment with chlorate, an inhibitor of proteoglycan sulfation, resulted in enhanced or reduced growth factor response, respectively, and eliminated the differences between FGF-1 and FGF-2. HSPGs isolated from trypsin digests of 3T3 cells had a much higher affinity for FGF-2 compared to that for FGF-1 when analyzed by affinity chromatography. Glycosaminoglycan chains or core protein fragments derived from the HSPG failed to show the same high apparent affinity for FGF-2, suggesting that an intact proteoglycan structure was important for the high FGF-2 affinity. Addition of HSPG ectodomains, isolated from cultured 3T3 cells or produced as recombinant molecules, to chlorate-treated cultures of 3T3 cells inhibited the mitogenic activity of FGF-2 and eliminated the effect of heparin as a potentiator of either growth factor. These results support the idea that the cell-associated HSPG is an integral component of the FGF signaling system and in 3T3 cells contributes to the increased sensitivity of these cells to FGF-2 compared to FGF-1. Since isolated ectodomains of HSPG inhibited rather than stimulated the mitogenic response of the FGFs, the proper anchoring of the HSPG in the cell membrane appears to be important for a stimulatory effect.
Plasmonic Metallurgy Enabled by DNA* (2020)

Noble-metal nanoparticles are ideal as nanoscale building blocks for new materials because their optical responses are dominated by localized surface plasmon resonance excitation, providing efficient and tunable absorption that is controlled by their size, shape, and composition. DNA uniquely enables the precise placement and manipulation of nanoparticles across multiple dimensions. Nanoparticles that are densely functionalized with DNA can be used as programmable atom equivalents, which enables the separation of the nanoparticle identity from arrangement. In bimetallic assemblies with homogeneous ordered layers, reflectivity can be precisely tailored by controlling the inter-layer interactions between Gold and Silver nanoparticles. Together, these data demonstrate that deliberate control over placement and ordering on the nanoscale can result in strikingly different optical properties for layered structures even though the layer structuring involves length scales much shorter than the wavelength of light.
The use of a removable appliance to relieve symptoms of burning lower lip in a dentate patient. (2005)

Solutions to some common, yet distressing, problems may well be appropriate for use in the Primary Dental Care setting. This solution to the problem of burning lower lip, may be useful for other patients with similar symptoms. It may be adapted for different clinical situations and is relatively non-invasive and reversible.
Uterine Preservation and Hysteropexy (2023)

An elongated cervix should therefore be considered a relative contraindication to uterine preservation surgery. Decisions surrounding uterine preservation versus hysterectomy should be considered from both patient and physician perspectives, incorporating a variety of factors ranging from anatomical, health and general function, and psychosocial. In one study exploring patient preferences regarding uterine preservation and hysterectomy in females undergoing surgery for POP, Korbly et al. found that geographic region, educational level, and social class were predictors of preference for uterine preservation. Some studies have demonstrated that uterine preservation is associated with shorter operative time, less estimated blood loss, and a quicker recovery when compared with vaginal hysterectomy. Overall, surgical safety, and the risk of complications which in some cases may be related to patient-specific comorbidities and/or previous intra-abdominal surgery, must be factored into decisions relating to hysterectomy versus uterine preservation.
Nonlinearly Induced Relaxation to the Ground State in a Two-Level System (2005)

We report the experimental demonstration of a nonlinear process in a two-level system, in which the amplitude of the excited state decays, transferring irreversibly a large fraction of its energy to the ground state, while shedding a part of it into radiation states. The experiments where preformed in a nonlinear optical waveguide, supporting two or three modes. The process is general, and is expected to occur in other nonlinear few level systems such as nonlinear quantum wells and Bose-Einstein condensates.
Graphene: Van der Waals Epitaxial Double Heterostructure: InAs/Single‐Layer Graphene/InAs (Adv. Mater. 47/2013) (2013)

Epitaxial semiconductor/graphene double heterostructures are fabricated by vapor-phase van der Waals epitaxy of InAs on both sides of suspended graphene, as reported on page 6847. K. S. Kim, Y. J. Hong and co-workers demonstrate that the weak van der Waals attraction facilitates a preferential growth direction of InAs exclusively along the As-polar direction, which results in a polarity inversion of the double heterostructures. The first-principles and density functional calculations clarify why and how the conductive graphene layer yields the polarity inversion for sp3/sp2/sp3-type double heterostructures.
Holter monitoring continuous telemetry from an ICD for troubleshooting and improved programming (2003)

The authors developed a modified Holter monitoring system for continuously recording the telemetered electrogram or marker channel from a new, tiered therapy implantable cardioverter/defibrillator (ICD) as an aid in ICD programming and to determine the cause of inappropriate therapy. The third generation, tiered therapy ICD, the Medtronic PCD Model 7217(B), can be programmed to transmit, for up to 63 h, either the device's marker channel, a series of coded pulses which show, among other things, the classification and timing of ventricular depolarizations sensed by the device, or the near-field or far-field electrogram. The new Holter system records the telemetry signal, using a PCD/Holter adapter, together with the surface electrocardiogram (ECG). To evaluate the performance and usefulness of this new system, two series of tests were performed with patients who received a PCD. This new system has been practical to use, flawless in performance, and invaluable in managing the treatment of PCD patients who actually or apparently receive inappropriate ICD therapy. Because the marker channel and the ECG are recorded simultaneously, this new system gives more information than either standard Holter monitoring or the read-out of stored electrograms from the memory of other third generation ICDs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Characterization of anti-SNAP25<sub>197</sub> monoclonal antibody 2E2A6. (2015)

&lt;p&gt;Specificity demonstrated by lack of cross-reactivity towards SNAP25&lt;sub&gt;206&lt;/sub&gt;. &lt;b&gt;A.&lt;/b&gt; Neuro-2a cells were treated with BoNT/A (150 kDa) from 0.01 to 10 nM (duplicate wells) for 24 h. Western blot was performed with 2E2A6 antibody (1 µg/mL). No cross-reactivity with SNAP25&lt;sub&gt;206&lt;/sub&gt; (no bands observed in the 0 nM BoNT/A lanes) and no other non-specific bands were detected in the whole blot. &lt;b&gt;B &amp; C.&lt;/b&gt; Surface plasmon resonance (SPR) was used to characterize the 2E2A6 antibody and to compare the binding affinity and binding kinetics of 2E2A6 and MC-6053. 2E2A6 bound SNAP25&lt;sub&gt;197&lt;/sub&gt; with high affinity and did not bind SNAP25&lt;sub&gt;206&lt;/sub&gt; at any of the concentrations tested up to 10 µM. MC-6053 was able to bind SNAP25&lt;sub&gt;206&lt;/sub&gt; with a K&lt;sub&gt;D&lt;/sub&gt; of 240 nM. &lt;b&gt;D.&lt;/b&gt; The K&lt;sub&gt;d&lt;/sub&gt; for 2E2A6 is tenfold lower than the K&lt;sub&gt;d&lt;/sub&gt; for MC-6053 as shown in the normalized graph resulting in better affinity.&lt;/p&gt;
Plasmonic Apertures: A Scalable Plasmonic Architecture for Enhanced Diamond Single Photon Sources (2011)

We propose and demonstrate that plasmonic apertures provide a scalable architecture for diamond NV center applications. Our results show that emission rates can be enhanced up to 60 times with collection efficiencies up to %40.
Unsupervised feature learning classification using an extreme learning machine (2013)

This paper presents a new approach, which we call UFL-ELM, to classification using both unsupervised and supervised learning. Unlike traditional approaches in which features are extracted, hand-crafted, and then trained using time-consuming, iterated optimization, this proposed method leverages unsupervised feature learning to learn features from the data themselves and then train the classifier using an extreme learning machine to reach the analytic solution. The result is therefore widely and quickly applied to universal data. Experiments on a large dataset of images confirm the ease of use and speed of training of this unsupervised feature learning approach. Furthermore, the paper discusses how to speed up training, using massively parallel programming.
Proteomic analysis of thioredoxin-targeted proteins in Escherichia coli (2004)

Thioredoxin, a ubiquitous and evolutionarily conserved protein, modulates the structure and activity of proteins involved in a spectrum of processes, such as gene expression, apoptosis, and the oxidative stress response. Here, we present a comprehensive analysis of the thioredoxin-linked Escherichia coli proteome by using tandem affinity purification and nanospray microcapillary tandem mass spectrometry. We have identified a total of 80 proteins associated with thioredoxin, implicating the involvement of thioredoxin in at least 26 distinct cellular processes that include transcription regulation, cell division, energy transduction, and several biosynthetic pathways. We also found a number of proteins associated with thioredoxin that either participate directly (SodA, HPI, and AhpC) or have key regulatory functions (Fur and AcnB) in the detoxification of the cell. Transcription factors NusG, OmpR, and RcsB, not considered to be under redox control, are also associated with thioredoxin.
Analysis of Defect in Extreme UV Lithography Mask Using a Modal Method Based on Nodal B-Spline Expansion (2005)

This paper details to an electromagnetic modeling of an extreme ultraviolet (EUV) lithography mask. For that purpose, a modal method based on a spline nodal expansion (MMSNE) is presented. The results obtained using first, and second-order splines as basis functions are compared with those obtained using other modal methods, such as modal method by Fourier expansion (MMFE). The agreement between the results obtained using different methods is very good, and a convergence test is also performed. The spline nodal basis function implemented in this paper is the first step toward the realization of a multiresolution scheme that is expected to perform much more efficiently than conventional schemes.
An RNA Fragment Consisting of the P7 and P9.0 Stems and the 3'-Terminal Guanosine of the Tetrahymena Group I Intron (1996)

On the basis of the nucleotide sequence of Tetrahymena group I intron, we constructed a 31 residue RNA that has the P7 stem and the 3′-terminal guanosine residue (3′-G) with a putative stem-loop structure (P9.0) intervening between them. For this model RNA (P7/P9.0/G), four residues around the guanosine binding site (GBS) in the P7 stem were found to exhibit much lower sensitivities to ribonuclease V1 than those of a variant RNA having adenosine in place of the 3′-G, suggesting that the 3′-G contacts around the GBS. NMR analyses of the imino proton resonances of the P7/P9.0/G RNA indicated that the base pairing in the GBS is retained on the interaction with the 3′-G, and that the two base pairs of the putative P9.0 stem-loop are definitely formed. Comparison of the RNA with its variants with either A (3′-A) or a deletion in place of the 3′-G suggested that the stability of the P9.0 stem-loop is affected by the GBS-3′-G interaction. The melting temperatures of the P9.0 stem-loop were determined from the UV absorbances of these RNAs, which quantitatively indicated that the P9.0 stem-loop is significantly stabilized by the interaction of the GBS with the 3′-G, rather than the 3′-A, and also by direct interaction with divalent cations (Mg2+, Ca2+ or Mn2+). Upon replacement of the G·C base pair by CG in the GBS of the P7/P9.0/G RNA, the specificity was switched from 3′-G to 3′-A, as in the case of the intact intron.
Lysine-specific gingipain promotes lipopolysaccharide- and active-vitamin D3-induced osteoclast differentiation by degrading osteoprotegerin (2008)

Porphyromonas gingivalis is one of the major pathogens of periodontitis, a condition characterized by excessive alveolar bone resorption by osteoclasts. The bacterium produces cysteine proteases called gingipains, which are classified according to their cleavage-site specificity into Kgps (lysine-specific gingipains) and Rgps (arginine-specific gingipains). In the present study we examined the effects of gingipains on osteoclast differentiation. In co-cultures of mouse bone-marrow cells and osteoblasts, formation of multinucleated osteoclasts induced by 1alpha,25(OH)(2)D(3) (1alpha,25-dihydroxyvitamin D(3)) was augmented by Kgp but not by RgpB. A physiological concentration (0.1 nM) of 1alpha,25(OH)(2)D(3) induced the osteoclast formation in the presence of 100 nM Kgp to an extent comparable with that induced by 10 nM 1alpha,25(OH)(2)D(3). Kgp also enhanced osteoclastogenesis induced by various microbial components, including lipopolysaccharide. Combined use of Kgp and 1alpha,25(OH)(2)D(3) or lipopolysaccharide also increased the number of resorption pits developed on dentin slices, indicating that the osteoclasts formed in the presence of Kgp possess bone-resorbing activity. The enhanced osteoclastogenesis by Kgp was correlated with a depletion of osteoprotegerin in co-culture medium and was proteolytic-activity-dependent, since benzyloxycarbonyl-L-phenylalanyl-L-lysylacycloxyketone, an inhibitor of Kgp, completely abolished osteoclastogenesis induced by Kgp. Kgp digested osteoprotegerin, since its recombinant protein was susceptible to degradation by Kgp in the presence of serum. As a result, Kgp did not augment osteoclastogenesis in co-cultures of osteoprotegerin-deficient osteoblasts and bone-marrow cells. In addition, enhanced osteoclastogenesis by Kgp was abolished by an excess amount of recombinant osteoprotegerin. These findings suggest that degradation of osteoprotegerin is one of the mechanisms underlying promotion of osteoclastogenesis by Kgp.
Perceptual Learning (2018)

Abstract Perceptual learning refers to a long‐term change in the ability to extract perceptual information from the environment that arises via experience or practice. In this chapter, we first explore many examples of perceptual learning in relatively simple as well as in more complex tasks. Furthermore, we do so across sensory modalities (vision, audition, touch, taste, smell) with the goal of highlighting the commonalities seen in perceptual learning across systems that are typically considered separately. We then consider the most substantial issues in the domain, including the question of learning specificity (i.e., when do improvements on one task transfer to new unpracticed tasks?), the conditions under which learning occurs, the neural basis of perceptual learning, computational models of perceptual learning, and potential real‐world applications of perceptual learning. We conclude with future directions; although the field has clearly made tremendous progress over the past century or more, there remain critical gaps in our knowledge that preclude our ability to fully harness perceptual learning to make a real‐world impact.
A Novel Boundary Element Method Using Surface Conductive Absorbers for Full-Wave Analysis of 3-D Nanophotonics (2011)

Fast surface integral equation (SIE) methods seem to be ideal for simulating 3-D nanophotonic devices, as such devices generate fields in both the interior device volume and in the infinite exterior domain. SIE methods were originally developed for computing scattering from structures with finite surfaces, and since SIE methods automatically represent the infinite extent of the exterior scattered field, there was no need to develop numerical absorbers. Numerical absorbers are needed when SIE methods are used to simulate nanophotonic devices that process or couple light, to provide nonreflecting termination at the optical ports of such devices. In this paper, we focus on the problem of developing an approach to absorbers that are suitable for port termination, yet preserve the surface-only discretization and the geometry-independent Green's function properties of the SIE methods. Preserving these properties allows the absorber approach to be easily incorporated in commonly used fast solvers. We describe our solution to the absorber problem, that of using a gradually increasing surface conductivity, and show how to include surface conductivity in SIE methods. We also analyze numerical results using our absorber approach to terminate a finite-length rectangular cross section dielectric waveguide. The numerical results demonstrate that our surface-conductivity absorber can easily achieve a reflected power of less than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-7</sup> , and that the magnitude of the transition reflection is proportional to 1/L <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2d+2</sup> , where <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">L</i> is the absorber length and <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</i> is the order of the differentiability of the surface conductivity function.