gebhart/patrepeval huggingface dataset:
Identification of Src, Fyn, and Lyn SH3-Binding Proteins: Implications for a Function of SH3 Domains (1994)

Src homology 3 (SH3) domains mediate protein-protein interactions necessary for the coupling of cellular proteins involved in intracellular signal transduction. We previously established solution-binding conditions that allow affinity isolation of Src SH3-binding proteins from cellular extracts (Z. Weng, J. A. Taylor, C. E. Turner, J. S. Brugge, and C. Seidel-Dugan, J. Biol. Chem. 268:14956-14963, 1993). In this report, we identified three of these proteins: Shc, a signaling protein that couples membrane tyrosine kinases with Ras; p62, a protein which can bind to p21rasGAP; and heterogeneous nuclear ribonucleoprotein K, a pre-mRNA-binding protein. All of these proteins contain proline-rich peptide motifs that could serve as SH3 domain ligands, and the binding of these proteins to the Src SH3 domain was inhibited with a proline-rich Src SH3 peptide ligand. These three proteins, as well as most of the other Src SH3 ligands, also bound to the SH3 domains of the closely related protein tyrosine kinases Fyn and Lyn. However, Src- and Lyn-specific SH3-binding proteins were also detected, suggesting subtle differences in the binding specificity of the SH3 domains from these related proteins. Several Src SH3-binding proteins were phosphorylated in Src-transformed cells. The phosphorylation of these proteins was not detected in cells transformed by a mutant variant of Src lacking the SH3 domain, while there was little change in tyrosine phosphorylation of other Src-induced phosphoproteins. In addition, the coprecipitation of v-Src with two tyrosyl-phosphorylated proteins with M(r)s of 62,000 and 130,000 was inhibited by incubation with a Src SH3 peptide ligand, suggesting that the binding of these substrate proteins is dependent on interactions with the SH3 domain. These results strongly suggest a role for the Src SH3 domain in the recruitment of substrates to this protein tyrosine kinase, either through direct interaction with the SH3 domain or indirectly through interactions with proteins that bind to the SH3 domain.
Modulation of Electronics and Thermal Stabilities of Photochromic Phosphino–Aminoazobenzene Derivatives in Weak-Link Approach Coordination Complexes (2013)

A series of d(8) transition-metal (Pt(II) and Pd(II)) coordination complexes incorporating phosphine-functionalized aminoazobenzene derivatives as hemilabile phosphino-amine (P,N) ligands were synthesized and studied as model weak-link approach (WLA) photoresponsive constructs. The optical and photochemical properties of these complexes were found to be highly influenced by various tunable parameters in WLA systems, which include type of metal, coordination mode, type of ancillary ligand, solvent, and outer-sphere counteranions. In dichloromethane, reversible chelation and partial displacement of the P,N coordinating moieties allow for toggling between aminoazobenzene- or pseudostilbene- and azobenzene-type derivatives. The reversible switching between electronic states of azobenzene can be controlled through either addition or extraction of chloride counterions and is readily visualized in the separation between π-π* and n-π* bands in the complexes' electronic spectra. In acetonitrile solution, the WLA variables inherent to semiopen complexes have a significant impact on the half-lives of the corresponding cis isomers, allowing one to tune their half-lives from 20 to 21000 s, while maintaining photoisomerization behaviors with visible light. Therefore, one can significantly increase the thermal stability of a cis-aminoazobenzene derivative to the extent that single crystals for X-ray diffraction analysis can be grown for the first time, uncovering an unprecedented edge-to-face arrangement of the phenyl rings in the cis isomer. Overall, the azobenzene-functionalized model complexes shed light on the design parameters relevant for photocontrolled WLA molecular switches, as well as offer new ways of tuning the properties of azobenzene-based, photoresponsive materials.
Identification of donors for low-nitrogen stress with maize lethal necrosis (MLN) tolerance for maize breeding in sub-Saharan Africa (2019)

After drought, a major challenge to smallholder farmers in sub-Saharan Africa is low-fertility soils with poor nitrogen (N)-supplying capacity. Many challenges in this region need to be overcome to create a viable fertilizer market. An intermediate solution is the development of maize varieties with an enhanced ability to take up or utilize N in severely depleted soils, and to more efficiently use the small amounts of N that farmers can supply to their crops. Over 400 elite inbred lines from seven maize breeding programs were screened to identify new sources of tolerance to low-N stress and maize lethal necrosis (MLN) for introgression into Africa-adapted elite germplasm. Lines with high levels of tolerance to both stresses were identified. Lines previously considered to be tolerant to low-N stress ranked in the bottom 10% under low-N confirming the need to replace these lines with new donors identified in this study. The lines that performed best under low-N yielded about 0. 5 Mg ha<sup>-1</sup> (20%) more in testcross combinations than some widely used commercial parent lines such as CML442 and CML395. This is the first large scale study to identify maize inbred lines with tolerance to low-N stress and MLN in eastern and southern Africa.
Somatosensory Processes (2009)

14.1 Psychophysics 14.2 Peripheral Receptors 14.3 Ascending Pathways 14.4 Cortical Processing of Tactile Information 14.5 Effects of Attention 14.6 Summary
Estimation of dynamic, in vivo soft‐tissue deformation: Experimental technique and application in a canine model of tendon injury and repair (2010)

Outcomes after rotator cuff surgery are typically assessed with measures of strength, joint motion, or pain, but these measures do not provide a direct assessment of tissue function as healing progresses. To address this limitation, this manuscript describes biplane X-ray analysis as a technique for quantifying in vivo soft-tissue deformation. Tantalum beads were implanted in the humerus and infraspinatus tendon in a canine model of tendon injury and repair. Biplane X-ray images were acquired during treadmill trotting and tissue deformation was estimated from the three-dimensional bead positions. Changes over time were characterized by the mean, range, and normalized range (i.e., range/mean) of interbead distance. Intact tendon repair tissue demonstrated significant decreases over time in the mean (p = 0.003), range (p = 0.001), and normalized range (p = 0.001) of interbead distance. Failed tendon repair tissue demonstrated significant decreases over time in the range (p = 0.05) and normalized range (p = 0.04) of interbead distance. In an uninjured control, differences over time in the interbead distance parameters were not detected. This approach is a promising technique for estimating changes over time in soft-tissue deformation. These preliminary data indicate appreciable differences between normal tendons, intact repairs, and failed repairs.
Electron focusing with multiparallel GaAs-AlGaAs wires defined by damageless processing (1990)

Magnetoresistance modulation, resulting from electron focusing, is investigated with multiparallel GaAs-AlGaAs wires, which are defined by electron beam lithography and damageless wet-chemical etching. Distinct focusing peaks in magnetoresistance are observed, although the samples have wires longer than a ballistic mean free path, which is derived from the focusing peak intensity. Specularity coefficient p for the etched region boundary is also obtained as p≊1 from the focusing peak ratio. The mechanism limiting ballistic transport in the electron focusing condition is discussed, based on the temperature and the electron density dependence of the peak intensity.
Implementation of Targeted Advertisement Services on ATSC 3.0 Runtime Environment (2019)

In this paper, we present an application service platform for targeted advertisement in ATSC 3.0. The implemented platform is fully compatible with ATSC 3.0 standards and comprises three parts: a transport system, a receiving system, and an application. The laboratory test results show that advertisement contents were successfully delivered in real-time and non-real-time over both broadcast and broadband networks. Personalized client-side advertisement switching was also performed based on application in ATSC 3.0 runtime environment.
Identical Consensus Sequence and Conserved Genomic Polymorphism of Hepatitis E Virus during Controlled Interspecies Transmission (2012)

High-throughput sequencing of bile and feces from two pigs experimentally infected with human hepatitis E virus (HEV) of genotype 3f revealed the same full-length consensus sequence as in the human sample. Twenty-nine percent of polymorphic sites found in HEV from the human sample were conserved throughout the infection of the heterologous host. The interspecies transmission of HEV quasispecies is the result of a genomic negative-selection pressure on random mutations which can be deleterious to the viral population. HEV intrahost nucleotide diversity was found to be in the lower range of other human RNA viruses but correlated with values found for zoonotic viruses. HEV transmission between humans and pigs does not seem to be modulated by host-specific mutations, suggesting that adaptation is mainly regulated by ecological drivers.
Results from long-term In-vivo Tests of a Wireless, Intravascular Blood-Pressure Monitoring System for Hypertension Patients (2012)

Introduction Long-term monitoring of malign hypertension patients is important for physicians to prescribe appropriate medical treatment in order to reduce the incidence of secondary consequences such as stroke, kidney failure or heart insufficiency. However, current devices are not suited for long-term blood-pressure measurement. In order to address this need, we developed and conducted in-vivo tests on a novel, fully-implantable, wireless blood-pressure monitoring system. Methods The monitoring system was tested for six months in 12 chronic ovine models. The sensor was implanted with X-raycontrol in the femoral artery by means of a dedicated sheath (PASIS). Reference measurements were recorded with industry standard pressure sensors post implantation. Position and proper functioning of the sensor were controlled via regular readout measurements and CTs. At the end of each trial, a histological examination was conducted. Results Chronic in-vivo studies revealed that blood pressure measurement over a period of six months was possible with the novel implantable sensor system. Stable pressure histories were recorded. However, the mechanical resilience of the sensor system requires improvement. The in-vivo tests in the femoral artery of sheep produced high stress on the sensors system. Several implanted systems became inoperative despite efforts to stiffen the sensor-cable. The histological analysis detected no thrombi, however mild ingrowth was observed in several cases. Conclusion The results of the chronic in-vivo tests on the novel implantable blood-pressure monitoring system were encouraging. Improvements need to be made regarding the mechanical resilience of the system and the coating needs to investigated to reduce ingrowth-behavior. Additional trials at a modified implantation spot will be conducted in order to reveal further insights regarding system performance.
Effect of Lithium Codoping on Dual Acceptor Doped ZnO (2011)

The origin of ferromagnetism in zinc oxide is not yet clear due to many reasons like nature of native defects, role of dopant ions, impurities etc. Numerous contrary reports are available regarding the appearance of RTFM in codoped zinc oxide. Reproducibility, complicated wet chemical synthesis, Appearance of quasi excitonic particles is responsible for non accountability of ferromagnetism in codoped zinc oxide.
Titelbild: Total Synthesis and Configurational Assignment of (−)‐Dictyostatin, a Microtubule‐Stabilizing Macrolide of Marine Sponge Origin / Total Synthesis of (−)‐Dictyostatin: Confirmation of Relative and Absolute Configurations (Angew. Chem. 35/2004) (2004)

Aus dem Meeresschwamm Corallistidae stammt (−)‐Dictyostatin, ein Tubuli‐stabilisierender Naturstoff, der gegen multiresistente Tumore wirksam sein könnte. Paterson et al. und Curran et al. beschreiben in ihren Zuschriften auf S. 4729 ff. und S. 4734 ff. die Totalsynthese dieser schwierigen Zielverbindung. Da die relative und absolute Konfiguration des Makrolactons zweifelsfrei feststehen, können die Synthese größerer Mengen des Wirkstoffs und das gezielte Design von Analoga beginnen. (Das Photo des Schwamms wurde von der Harbor Branch Oceanographic Institution zur Verfügung gestellt.)
Surface conditioning of active molybdenum field emission cathode arrays with H2 and helium (1998)

We studied the interaction of active molybdenum field emitter arrays with molecular hydrogen and helium. Upon impact with the field emitted electrons, H2 gas introduced into the system undergoes dissociation and ionization. The emitter surface is conditioned through the interaction of the hydrogen atoms and ions with molybdenum, resulting in the formation of volatile molybdenum hydrides. The volatile species are removed by the vacuum system. Surface conditioning of the tips is reflected in the reduced work function and increased electron emission. Emission enhancement reaches a maximum for total exposures of 1000–1500 L (1 L=1×10−6 Torr s) of H2. For small exposures of helium (&amp;lt;1500 L), emission enhancement is also observed. Larger exposures result in significant emission degradation. We propose that the interaction of H2 with active molybdenum field emission arrays can be used as an efficient, ultrahigh vacuum compatible method for in situ cleaning of the field emitter arrays.
Ética para la bioética y a ratos para la política (2003)

Arginine-vasopressin (AVP) plays an important role in regulating water balance in humans. Its secretion is under control of several mechanisms, some of which are not completely understood. The purpose of the present study was to evaluate the effects of an acute oral salt load on AVP secretion in normal subjects. Six normal volunteers received 350 mEq of NaCl per os. Pulmonary capillary wedge pressure and right atrial pressure, plasma AVP, plasma sodium and potassium concentration, plasma osmolality, hematocrit, urinary sodium and potassium excretion, and urinary flow were measured at baseline and every 30 minutes for two hours after the salt load. Hemodynamics as well as urinary sodium and potassium excretion did not change over the study. Ninety minutes after the salt load, plasma AVP increased from the basal value of 6.0 +/- 0.9 pg per ml to 10.1 +/- 1.2 pg per ml (mean +/- SE, p less than 0.005) and a significant reduction in diuresis of about 50% was observed. However, plasma osmolality and plasma sodium concentration increased significantly only 120 min after the salt load, from the initial value of 277.7 +/- 2.2 mOsm per kg and 145.3 +/- 1.4 mEq per 1 (mean +/- SE) to 284.8 +/- 2.5 mOsm per kg and 148.7 +/- 1.5 mEq per 1, respectively (p less than 0.01). Ninety minutes after the salt load, no correlation was found between plasma osmolality and plasma AVP concentration, indicating that AVP secretion was independent of changes in systemic blood osmolality.(ABSTRACT TRUNCATED AT 250 WORDS)
An analytical framework for quantifying wildland fire risk and fuel treatment benefit (2006)

Federal wildland fire management programs have readily embraced the practice of fuel treatment. Wildland fire risk is quantified as expected annual loss ($ yr –1 or $ yr –1 ac –1). Fire risk at a point on the landscape is a function of the probability of burning at that point, the relative frequency of fire behaviors expected if the point does burn, and the response of various resources to those expected fire behaviors (net value change). The probability of fire burning at any point on the landscape is a function of the spatial arrangement of fuel, weather, topography, and ignition locations surrounding the point of interest, but not characteristics of the point itself. Relative frequency of fire behavior is a function of the local fire environment and the likelihood of burning at various portions of an assumed elliptical fire. Fire loss is assumed to be a function of fire behavior characteristics. Fire behavior can be measured by the Fire Intensity Index (FII), the common logarithm of fireline intensity. A risk reduction treatment is an investment of capital today for a benefit to be reaped in the future. The benefit of a risk reduction treatment is the present value of the difference in risk with and without treatment. Cost is the present value of current year and future treatment expenditures. Fuel treatment benefit-cost ratio is a measure of efficiency; it is one of many factors that inform a fire management decision.
ChemInform Abstract: Enantioselective Syntheses of 2‐Deoxyxylono‐1,4‐lactone and 2‐Deoxyribono‐1,4‐lactone from 1,3‐Dioxan‐5‐yl Diazoacetates. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Development of a Compliant Nanothermal Interface Material (2011)

The power density requirements continue to increase and the ability of thermal interface materials has not kept pace. Increasing effective thermal conductivity and reducing bondline thickness reduce thermal resistance. High thermal conductivity materials, such as solders, have been used as thermal interface materials. However, there is a limit to minimum bondline thickness in reducing resistance due to increased fatigue stress. A compliant thermal interface material is proposed that allows for thin solder bondlines using a compliant structure within the bondline to achieve thermal resistance &lt;0.01 cm2C/W. The structure uses an array of nanosprings sandwiched between two plates of materials to match thermal expansion of their respective interface materials (ex. silicon and copper). Thin solder bondlines between these mating surfaces and high thermal conductivity of the nanospring layer results in thermal resistance of 0.01 cm2C/W. The compliance of the nanospring layer is two orders of magnitude more compliant than the solder layers so thermal stresses are carried by the nanosprings rather than the solder layers. The fabrication process and performance testing performed on the material is presented.
A Review of Perennial Ryegrass Endophytes and Their Potential Use in the Management of African Black Beetle in Perennial Grazing Systems in Australia (2017)

The major insect pest of Australian cool temperate pastures is the root-feeding insect <i>Heteronychus arator</i> (African black beetle, ABB). Significant pasture damage can occur even at low ABB densities (11 individuals per square meter), and often re-sowing of the whole paddock is required. Mitigation of the effects of pasture pests, and in particular subterranean species such as the larval form of ABB, can be challenging. Early detection is limited by the ability to visualize above-ground symptoms, and chemical control of insects in soil is often ineffective. This review takes a look at the historical events that molded the pastoral landscape in Australia. The importation route, changes in land management and pasture composition by European settlers may have aided the establishment of ABB in Australia. Perennial ryegrass <i>Lolium perenne</i> is discussed as it is one of the most important perennial agricultural grasses and is widely-sown in moderate-to-high-rainfall temperate zones of the world. Endophytic fungi from the genus <i>Epichloë</i> form symbiotic relationships with cool season grasses such as <i>Lolium perenne</i> (perennial ryegrass). They have been studied extensively and are well documented for enhancing persistence in pasture via a suite of bioactive secondary metabolites produced by the fungal symbionts. Several well-characterized secondary metabolites are discussed. Some can have negative effects on cattle (e.g., ergovaline and lolitrems) while others have been shown to benefit the host plant through deterrence of insect pests from feeding and by insecticidal activity (e.g., peramine, lolines, ergopeptines). Various control methods for ABB are also discussed, with a focus on the potential role of asexual <i>Epichloë</i> endophytes.
Use of heparin-bonded surfaces in cardiopulmonary bypass (1993)

Heparin surface coating is a convenient means of improving the thrombo resistance of blood-exposed surfaces. At this time, heparin can be bonded to oxygenator/heat-exchanger structures, soft venous reservoirs, cardiotomy reservoirs, centrifugal pump heads, tubings, and cannulae. Following experimental evaluation, these devices have become available for clinical application. Cardiopulmonary bypass with low or no systemic heparinization can be realized in selected cases. Improved haemostasis in combination with modification of standard surgical techniques results in limited blood loss and reduced transfusion requirements and appears to be the main benefit of cardiopulmonary bypass with heparin-bonded surfaces. Experience using heparin- bonded equipment in various clinical situations is reviewed.
Dual Bracing for Ulnar Collateral Ligament Injuries Restores Native Valgus Laxity and Native Medial Joint Gapping of the Elbow (2023)

This study provides biomechanical data on the dual-bracing approach that may help surgeons to consider this new method of addressing acute humeral UCL lesions.
Effects of Net and Solid Skins on Self-Supporting Lattice Structures (2015)

Multi-functional capabilities of Lattice materials allow them to be used in weight bearing applications, impact absorption and heat dissipation. Previously, the range of cellular materials was limited by constraints in traditional manufacturing technologies. This situation has been mitigated by advances in additive manufacturing (AM) techniques, which allows the manufacture of complex parts directly from three dimensional CAD models. However, other manufacturing difficulties emerge with AM techniques. Such difficulties exist with metallic components produced with selective laser melting (SLM). The need for support could compromise the quality of the lattice being built since it is difficult to remove such structures. Lattices requiring little or no support are better suited for SLM. A method was recently developed to fit such lattices to complicated three dimensional domains and consist of an approach to improve the performance of the trimmed lattices with solid and net skins. In this paper, we investigate the influence of these skins on the stiffness of Body-Centred Cubic (BCC) and Double-Gyroid (Dgyroid) lattices via finite element analysis. Including a net skin on the BCC lattice improved its stiffness as the thickness of the skin was increased. The stiffness of Dgyroid lattice was insensitive to a net skin. However, solid skins improve the performance of both lattice types.