gebhart/patrepeval huggingface dataset:
P13. Intra-tumoral and surrogate immune responses in patients treated with the engineered anti-PD-L1 antibody (MPDL3280A) (2014)

Meeting abstracts PD-L1 regulates CD8 T cell/Th1 immune responses. PD-L1 expressed in the tumor microenvironment can bind to PD-1 or B7.1 on activated T cells and mediate cancer immune evasion. MPDL3280A is a human mAb containing an engineered Fc-domain designed to optimize efficacy and safety that
A hollow Co3−xCuxS4 with glutathione depleting and photothermal properties for synergistic dual-enhanced chemodynamic/photothermal cancer therapy (2022)

Chemodynamic therapy has become an emerging cancer treatment strategy, in which tumor cells are killed through toxic reactive oxygen species (ROS), especially hydroxyl radicals (˙OH) produced by the Fenton reaction. Nevertheless, low ROS generation efficiency and ROS depletion by cellular antioxidant systems are still the main obstacles in chemodynamic therapy. In the present work, we propose a dually enhanced chemodynamic therapy obtained by inhibiting ˙OH consumption and promoting ˙OH production based on the administration of bimetallic sulfide Co<sub>3-<i>x</i></sub>Cu<sub><i>x</i></sub>S<sub>4</sub> nanoparticles functionalized by polyethylene glycol. These bimetallic nanoparticles display glutathione depleting and photothermal properties. The nanoparticles are gradually degraded in a tumor microenvironment, resulting in Co<sup>2+</sup> and Cu<sup>2+</sup> release. The released Co<sup>2+</sup> triggers a Fenton-like reaction that turns endogenous hydrogen peroxide into highly toxic ˙OH. In the cellular environment, Cu<sup>2+</sup> ions are reduced to Cu<sup>+</sup> by endogenous GSH, which decreases the intracellular antioxidant capacity and additionally up-regulates ˙OH production <i>via</i> the Cu<sup>+</sup>-induced Fenton-like reaction. Moreover, under near-infrared light irradiation, the bimetallic nanoparticles display a photothermal conversion efficacy of 46.7%, which not only improves chemodynamic therapy <i>via</i> boosting a Fenton-like reaction but results in photothermal therapy through hyperthermia. Both <i>in vitro</i> cancer cell killing and <i>in vivo</i> tumor ablation experiments show that the bimetallic nanoparticles display outstanding therapeutic efficacy and negligible systemic toxicity, indicating their anticancer potential.
Non Invasive ECG Mapping To Guide Catheter Ablation. (2014)

Since more than 100 years, 12-lead electrocardiography (ECG) is the standard-of-care tool, which involves measuring electrical potentials from limited sites on the body surface to diagnose cardiac disorder, its possible mechanism and the likely site of origin. Several decades of research has led to the development of a 252-lead-ECG and CT-scan based, three dimensional, electro-imaging modality to non-invasively map abnormal cardiac rhythms including fibrillation. These maps provide guidance towards ablative therapy and thereby help advance the management of complex heart rhythm disorders. Here, we describe the clinical experience obtained using non-invasive technique in mapping the electrical disorder and guide the catheter ablation of atrial arrhythmias (premature atrial beat, atrial tachycardia, atrial fibrillation), ventricular arrhythmias (premature ventricular beats) and ventricular pre-excitation (Wolff-Parkinson-White syndrome).
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. (2017)

To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation using the 1000 Genomes multiethnic reference panel. Promising association signals were followed up in additional data sets (of 14,545 or 7,397 T2D case and 38,994 or 71,604 control subjects). We identified 13 novel T2D-associated loci (P &lt; 5 × 10(-8)), including variants near the GLP2R, GIP, and HLA-DQA1 genes. Our analysis brought the total number of independent T2D associations to 128 distinct signals at 113 loci. Despite substantially increased sample size and more complete coverage of low-frequency variation, all novel associations were driven by common single nucleotide variants. Credible sets of potentially causal variants were generally larger than those based on imputation with earlier reference panels, consistent with resolution of causal signals to common risk haplotypes. Stratification of T2D-associated loci based on T2D-related quantitative trait associations revealed tissue-specific enrichment of regulatory annotations in pancreatic islet enhancers for loci influencing insulin secretion and in adipocytes, monocytes, and hepatocytes for insulin action-associated loci. These findings highlight the predominant role played by common variants of modest effect and the diversity of biological mechanisms influencing T2D pathophysiology.
Path loss, scattering and multipath delay statistics in four European cities for digital cellular and microcellular radiotelephone (1991)

The authors present typical and worst-case root mean square (RMS) delay spreads and excess delay spreads (10 dB) and mean channel path loss at 900 MHz in four European cities using typical cellular and microcellular antenna locations. Several thousand power delay profile measurements were made at six typical cellular and microcellular base station locations in the four cities. The data were obtained at local worst-case time-dispersion locations over hundreds of kilometers of typical operating routes, such as highways, bridges, and city streets, and form the basis for statistical models which can be used to predict the percentage of locations or the percentage of time in which channels will possess particular values of RMS delay spread and excess delay spread. The effect of reference distance on wideband path loss and the propagation path loss laws for cellular and microcellular radio channels are given. Radar cross sections computed from the data for typical scatterers in cellular and microcellular radio channels are given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A Lead Garment Structural Systemto Reduce Musculoskeletal Stress During Fluoroscopy (2019)

Abstract Cardiovascular, orthopedic, and interventional radiology procedures using fluoroscopy require healthcare professionals to wear heavy lead garments for radiation protection, which can lead to musculoskeletal injuries, discomfort, and fatigue. A mobile lead garment frame, MobiLead, was designed to mitigate these issues by moving the lower garment load off body to a structural frame and redistributing the load of the upper garment from the shoulders to the hips through a torso frame. The frame was designed to be compact with a minimal footprint for maneuverability in operating rooms with limited space, while still giving the surgeon adequate mobility for various emergency procedures. Preliminary analysis of device efficacy was conducted using electromyography (EMG) of load-bearing muscles during use and qualitative surgeon user feedback surveys. Nonparametric permutation tests showed that the MobiLead device mean activation was significantly lower than the standard lead garment (p&amp;lt;0.001). Surgeon feedback and use testing showed that the device fits under a sterile gown and is maneuverable in an operating room (OR).
High HER2 Expression Correlates with Response to the Combination of Lapatinib and Trastuzumab (2014)

Increasing HER2 protein expression correlated with increased benefit of adding lapatinib to trastuzumab. HER2 expression is a stronger predictor of pCR and PFS than p95HER2 for response to lapatinib, trastuzumab and, more significantly, L+T.
Privacy-friendly secure bidding scheme for demand response in smart grid (2015)

Smart grid is an emerging technology because of its attractive features, such as distributed energy control and robust load fluctuation management. Demand Response (DR) system is an important component of smart grid as it can help maintaining demand-supply balance and controlling electricity bills at the user end. One of the visions of smart grid technology is communication between consumers and suppliers to facilitate certain types of DR strategies such as demand bidding (DR-DB). DR-DB is one kind of incentive-based DR, where certain incentives are awarded to consumers who participate in DR events. However, security and privacy of DR-DB bidding process are of paramount importance as consumer data is used during the process. In this paper we propose a secure and private bidding protocol for incentive-based demand-response system using cryptographic primitives without assuming any trusted computing or trusted third party. Alongside security and privacy, we show that consumer's registration, revocation of consumers by the system, and incentive claim by the winning bidder are very easy to handle.
Non‐specific potentiation of T‐ and B‐lymphocyte proliferation at the early stage of infection by Schistosoma mansoni: role of factors secreted by the larvae (1984)

The response of rat lymphocytes to schistosomula released products (SRP) was examined. SRP non-specifically activated lymphocytes by potentiating their proliferative response to PHA, Con A or LPS. The parasite factor involved was dialysable and heat stable. The addition of SRP to cultures containing nylon-wool non-adherent lymph node cells resulted in a significant enhancement of cell proliferation. The effect of SRP on athymic nude (Nu/Nu) and litter mate (Nu/+) control rat cells indicated an effect on the proliferation of both B and T lymphocytes. SRP acted in a dose-dependent manner and its action was observed as early as the beginning of cell division. This corresponds to the in vivo situation, since at the early stage of infection increased proliferative responses of the lymph node cells to mitogens were observed. The adjuvant effect of SRP could partly explain the regulation of the cellular immune response observed during S. mansoni infection by the parasite itself and could represent one of the mechanisms involved in immunity to reinfection that is under the control of the parasite.
Changing utilization of Stavudine (d4T) in HIV‐positive people in 2006–2013 in the EuroSIDA study (2015)

d4T use has declined sharply since 2006 to low levels in most regions; however, a low but persistent level of d4T use remains in Eastern Europe, where new d4T initiations post 2006 are also more common. The reasons for the regional differences may be multifactorial, but it is important to ensure that all clinicians treating HIV-positive patients are aware of the potential harmful effects associated with d4T.
Introduction to Homogeneous Catalysis: Carbon-Carbon Bond Formation Catalyzed by a Defined Palladium Complex (2000)

In this laboratory experiment students synthesize a phosphine ligand, P(o-tol)3, and with it the corresponding cyclometallated Pd(II) complex. This complex is an extremely active (pre)catalyst for C-C-bond-forming reactions (e.g. the Heck vinylation or the Grignard cross-coupling reaction). Students test the complex for activation in the catalysis of these two reactions using especially economical bromoaromatic compounds. The catalytic mechanisms of these reactions involve basic reaction types in organometallic chemistry such as ligand exchange, cyclometallation, oxidative addition, transmetallation, olefin insertion, reductive elimination and ß-hydride elimination. This experimental sequence combines synthetic organometallic and synthetic organic chemistry to introduce students to the field of catalysis as it appears in daily scientific research laboratory work.
Distributed Power Control In Downlink Cellular Massive Mimo Systems (2018)

This paper compares centralized and distributed methods to solve the power minimization problem with quality-of-service (QoS) constraints in the downlink (DL) of multi-cell Massive multiple-input multiple-output (MIMO) systems. In particular, we study the computational complexity, number of parameters that need to be exchanged between base stations (BSs), and the convergence of iterative implementations. Although a distributed implementation based on dual decomposition (which only requires statistical channel knowledge at each BS) typically converges to the global optimum after a few iterations, many parameters need to be exchanged to reach convergence.
First Midi Science Observations on VLT (2004)

The mid-infrared interferometric instrument MIDI has performed its first scientific observations on the Very Large Telescope Interferometer (VLTI) in June 2003. It allows interferometric observations over the 8--13 mu m wavelength range, with a spatial resolution up to 20 milliarcsec, a spectral resolution of 30 and 250, and an expected point source sensitivity of l N = 4 mag or 1 Jy for self-fringe tracking, which is the only observing mode during the first months of operation. We describe briefly the layout of the instrument and present the first status of the MIDI observations of Young Stellar Objects.
Discovering Interesting Subsets Using Statistical Analysis (2008)

In this paper we present algorithms for identifying interesting subsets of a given database of records. In many real life applications, it is important to automatically discover subsets of records which are interesting with respect to a given measure. For example, in the customer support database, it is important to identify subsets of tickets having service time which is too large (or too small) when compared with the service time of the rest of the tickets. We use Student’s t-test to check whether the measure values for a subset and its complement differ significantly. We first discuss the brute-force approach and then present heuristic-based state-space search algorithm to discover interesting subsets of the given database. To use the proposed heuristic-based approach on large data sets, we then present a samplingbased algorithm that uses sampling together with the proposed heuristics to efficiently identify interesting sets in large data sets. We discuss an application of these techniques to customer support data, to discover subsets of tickets that have significantly worse (or better) service times than the rest of the tickets. 1
USE OF LIVE ATTENUATED COLD-ADAPTED INFLUENZA A REASSORTANT VIRUS VACCINES IN INFANTS, CHILDREN, YOUNG ADULTS, AND ELDERLY ADULTS (1993)

From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
Implementation of a microprocessor based accounting system for agricultural uses. (1980)

This study has demonstrated the feasibility of using microcomputers on the farm or in the home to solve problems involving manipulation of large quantities of data or detailed mathematical procedures. A microcomputer with at least 32,000 words of memory and magnetic disk storage is recommended for efficient data processing. This capacity is required for programs of the type presented in this publication. A printer with at least an 80 character line is an essential feature. It is frequently necessary to have hard copy printouts of financial statements or cash flows in order to document the farm financial position. Programs may be prepared to serve this purpose if a printer is available. Without the printer, it is necessary to prepare documents from data viewed on a video screen. Other important features to consider in a microcomputer system include the capability for expansion and hardware compatibility with larger computer systems. Additional work is needed to develop software that is necessary in order to make the microcomputer a useful tool. Some farmers are beginning to purchase microcomputers being produced commercially. As these farmers grow in numbers, there will be an increasing demand for programs to meet their needs.
Pareto-Optimal Design and Performance Mapping of Telecom Rectifier Concepts (2010)

In the course of the design of single-phase PFC rectifiers, the demand for a high efficiency η and a high power density ρ must be met at the same time. Depending on the weight on these two design criteria different topologies could be advantageous. However, a comprehensive comparison of the topologies is difficult, since a large number of parameters must be determined and constraints in different physical domains, as e.g. magnetic or thermal properties, and EMI issues must be considered. Therefore, in this paper an approach based on relatively simple analytical equations is presented for calculating the limiting curves of conventional, bridgeless and TCM resonant-transition single-phase PFC rectifiers in the ρ-η-plane. These Pareto-Limits represent the Topology Performance Map of the considered topologies and allow a direct comparison of the achievable performance and the limitations with respect to power density and/or efficiency.
A Simple and High-Performance Method for Combining Soft-Decision FEC with Differential Encoding in 100 Gbps Dual-Polarization QPSK System (2014)

By a joint design of FEC and modulation, we demonstrate that it is possible to associate strong SD-FEC and differentially-encoded QPSK systems with negligible coding gain penalty and minor modifications in existing transceivers. The resulting system is robust to cycle slips.
Multidirection Validation of a Finite Element 50th Percentile Male Hybrid III Anthropomorphic Test Device for Spaceflight Applications (2018)

The use of anthropomorphic test devices (ATDs) for calculating injury risk of occupants in spaceflight scenarios is crucial for ensuring the safety of crewmembers. Finite element (FE) modeling of ATDs reduces cost and time in the design process. The objective of this study was to validate a Hybrid III ATD FE model using a multidirection test matrix for future spaceflight configurations. Twenty-five Hybrid III physical tests were simulated using a 50th percentile male Hybrid III FE model. The sled acceleration pulses were approximately half-sine shaped, and can be described as a combination of peak acceleration and time to reach peak (rise time). The range of peak accelerations was 10-20 G, and the rise times were 30-110 ms. Test directions were frontal (-GX), rear (GX), vertical (GZ), and lateral (GY). Simulation responses were compared to physical tests using the correlation and analysis (CORA) method. Correlations were very good to excellent and the order of best average response by direction was -GX (0.916±0.054), GZ (0.841±0.117), GX (0.792±0.145), and finally GY (0.775±0.078). Qualitative and quantitative results demonstrated the model replicated the physical ATD well and can be used for future spaceflight configuration modeling and simulation.
Rectification of radio frequency current in ferromagnetic nanowire (2007)

The authors report the rectification of a constant wave radio frequency (rf) current by using a single-layer magnetic nanowire; a direct-current voltage is resonantly generated when the rf current flows through the nanowire. The mechanism of the rectification is discussed in terms of the spin-torque diode effect reported for magnetic tunnel junction devices, and the rectification is shown to be directly attributable to resonant spin wave excitation by the rf current.
HIGH RESOLUTION GENERATION EXPANSION PLANNING CONSIDERING FLEXIBILITY NEEDS: THE CASE OF SWITZERLAND IN 2030 (2021)

This paper presents a static generation expansion planning formulation in which operational and investment decisions for a wide range of technologies are co-optimized from a centralized perspective. The location, type and quantity of new generation and storage capacities are provided such that system demand and flexibility requirements are satisfied. Depending on investments in new intermittent renewables (wind, PV), the flexibility requirements are adapted in order to fully capture RES integration costs and ensure normal system operating conditions. To position candidate units, we incorporate DC constraints, nodal demand and production of existing generators as well as imports and exports from other interconnected zones. To show the capabilities of the formulation, high-temporal resolution simulations are conducted on a 162-bus system consisting of the full Swiss transmission grid and aggregated neighboring countries.
Radiosensitization by Antisense Anti-MDM2 Mixed-Backbone Oligonucleotide in in Vitro and in Vivo Human Cancer Models (2004)

These results suggest that MDM2 has a role in radiation therapy of human cancers, regardless of p53 status, providing a basis for future development of MDM2 inhibitors, such as antisense oligonucleotides, as radiosensitizers.
On Interface Property Characterization and Performance of Fiber Reinforced Cementitious Composites (1999)

Peer Reviewed
Comparison of migration behavior between single and dual lag screw implants for intertrochanteric fracture fixation (2009)

The single and double lag screw implants demonstrated a significantly different migration resistance in surrogate specimens under gait loading simulation with the HIPS model. In this model, the double screw construct provided significantly greater resistance against varus collapse and neck rotation in comparison to a standard DHS lag screw implant.
Rule-based query optimization in extensible database systems (1987)

This thesis presents the problems of query optimization in extensible database systems and proposes a solution. It describes the design and an initial evaluation of the query optimizer generator developed for the EXODUS extensible database system. The goal of the EXODUS system is to provide software tools and libraries to structure and to ease the task of implementing or extending a database system for a new data model. Our basic model of optimization is to map a query tree, which consists of operators at the nodes and stored data at the leaves, to an access plan, which is a tree with implementation methods at the nodes and scans at the leaves. The optimizer generator translates algebraic equivalence rules into an executable optimizer. The equivalence rules are specific to the data model. The generated optimizer reorders query trees and selects implementation methods according to cost functions associated with the methods. The search strategy of the optimizer avoids exhaustive search by learning from past experience.
We report on two operational optimizers. Experiments with a restricted relational system show that the generated optimizer produces access plans of almost the same anticipated execution cost as those produced by exhaustive search, with the search time cut to a small fraction. Another set of experiments shows that a generated optimizer is able to handle large queries.
An optimizer currently under development for a new query evaluation method shows the power and flexibility of the approach. Other researchers have decided to use the optimizer generator for their database implementation work.
Independently from the EXODUS project, the optimizer generator proved to be a valuable tool for exploring the trade-offs between left-deep execution trees and general execution trees in relational database systems. Our experiments show that for bushy trees, the higher optimization cost and the cost for creating and reading temporary files can be more than compensated by the reduction in processing cost.