gebhart/patrepeval huggingface dataset:
Obinutuzumab (GA101) More Potently Engages Phagocytic-Lineage Cells Resulting In Enhanced Monocyte and Macrophage Activity When Compared To Rituximab and Ofatumumab (2013)

Abstract Therapeutic antibodies possess several clinically relevant mechanisms of action including cell death induction, perturbation of tumor cell signaling, activation of complement dependent cytotoxicity (CDC), antibody dependent cellular cytotoxicity (ADCC), antibody dependent cellular phagocytosis (ADCP) and induction of adaptive immunity. Obinutuzumab (GA101) is a novel humanized, glycoengineered Type II anti-CD20 monoclonal antibody engineered for displaying enhanced FcγRIIIa (CD16) binding affinity and characterized by stronger induction of ADCC and direct tumor cell death when compared to wild-type, Type I anti-CD20 antibodies rituximab and ofatumumab. In light of the important role of phagocytic lineage cells in the mechanism of action of therapeutic antibodies, we compared GA101, rituximab and ofatumumab for their ability to trigger FcγR-dependent monocyte and macrophage effector functions. We show that, due to glycoengineering, GA101 displays superior CD16-dependent binding to monocytes, M1 and M2c macrophages in presence of nonspecific, competing, human endogenous IgGs, a situation that more closely mimics physiological conditions. Subsequently, GA101 more strongly engages monocytes and macrophages and leads to significantly higher elimination of CD20-expressing tumor cells as shown by assays detecting total antibody activity (ADCP, ADCC and direct effects). In support of the stronger GA101 activity, higher nitric-oxide (NO) levels are also detected in supernatants of tumor/macrophage co-cultures treated with antibody. Taken together, our data show that in addition to stronger NK-cell mediated ADCC and direct cell death induction due to Type II CD20 binding, GA101 more potently engages phagocytic-lineage cells resulting in enhanced monocyte and macrophage activity under conditions that more closely resemble physiological settings. Disclosures: Herter: Roche: Employment. Klein:Roche Glycart AG: Employment. Umana:Roche: Employment, Equity Ownership. Bacac:Roche: Employment.
Temperature-dependent changes in the folding pattern of a simple triamide (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTemperature-dependent changes in the folding pattern of a simple triamideSamuel H. Gellman, Bruce R. Adams, and Gregory P. DadoCite this: J. Am. Chem. Soc. 1990, 112, 1, 460–461Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/ja00157a077https://doi.org/10.1021/ja00157a077research-articleACS PublicationsRequest reuse permissionsArticle Views302Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Non-cell-autonomous OTX2 transcription factor regulates anxiety-related behavior in the mouse (2021)

The OTX2 homeoprotein transcription factor is expressed in the dopaminergic neurons of the ventral tegmental area, which projects to limbic structures controlling complex behaviors. OTX2 is also produced in choroid plexus epithelium, from which it is secreted into cerebrospinal fluid and transferred to limbic structure parvalbumin interneurons. Previously, adult male mice subjected to early-life stress were found susceptible to anxiety-like behaviors, with accompanying OTX2 expression changes in ventral tegmental area or choroid plexus. Here, we investigated the consequences of reduced OTX2 levels in Otx2 heterozygote mice, as well as in Otx2<sup>+/AA</sup> and scFvOtx2<sup>tg/0</sup> mouse models for decreasing OTX2 transfer from choroid plexus to parvalbumin interneurons. Both male and female adult mice show anxiolysis-like phenotypes in all three models. In Otx2 heterozygote mice, we observed no changes in dopaminergic neuron numbers and morphology in ventral tegmental area, nor in their metabolic output and projections to target structures. However, we found reduced expression of parvalbumin in medial prefrontal cortex, which could be rescued in part by adult overexpression of Otx2 specifically in choroid plexus, resulting in increased anxiety-like behavior. Taken together, OTX2 synthesis by the choroid plexus followed by its secretion into the cerebrospinal fluid is an important regulator of anxiety-related phenotypes in the mouse.
Peripheral Nerve Lymphoma: Clinical, electrophysiological, radiographic and pathological findings. (P2.002) (2015)

BACKGROUND: Neurolymphomatosis (NL) is a rare presentation of lymphoma in peripheral nerves. OBJECTIVE: To determine the electrophysiological, radiographical, pathological findings and neuropathy pattern in NL. METHODS: Retrospective review of NL patients proven by nerve biopsy. RESULTS: 48 NL patients were identified (28 primary and 20 secondary NL). The most common presentations were asymmetric, painful radiculoplexus neuropathy (37.5[percnt]), polyradiculoneuropathy (23[percnt]) and multiple or single mononeuropathy (18[percnt]). Primary and secondary NL presented similarly with primary NL having longer symptom duration (10 vs. 6 months, p< 0.001), single disease episode (96[percnt] vs. 35[percnt], p< 0.001), disease remission (58[percnt] vs. 20[percnt], p = 0.056) and lower mortality (25[percnt] vs.67[percnt], p = 0.054). 11 of 42 patients had electrophysiology showing demyelination. Nerve biopsies diagnostic of lymphoma were distal cutaneous (sural; 9/11) or proximal targeted fascicular (35/35). MRI was better identifying lymphoma than CT or PET (84[percnt] vs. 46[percnt] vs. 58[percnt]). The lymphomas were B cell (46/48; only 2 T cell) with diffuse large B cell most common. Teased fibers showed increased demyelination (19/24), axonal degeneration (18/24) and empty nerve strands (9/24). Endoneurial lymphoma was common (43/48) follow by epineurial (29/33). Clinical and pathology of primary and secondary NL were similar except secondary NL having shorter neuropathic duration (8.5 vs. 4.5 months; p=0.01), more frequent with other organ involvement (39 vs. 70[percnt]; p=0.045), more axonal degeneration (31[percnt] vs. 7[percnt]; p=0.005), less favorable response to treatment and higher mortality rate. CONCLUSIONS: 1) Peripheral nerve lymphoma (NL) is a multifocal painful neuropathy that causes endoneurial inflammatory demyelination. 2) Primary NL presents as single episodes. Secondary NL presents after remission suggesting that nerve may act as a “safe lymphoma haven” - most chemotherapeutic agents cannot cross the blood nerve barrier. 3) Primary NL is less severe with longer disease duration, less axonal degeneration, more favorable response to treatment and higher survival rates.
60 Hz magnetic field susceptibility tests of CRT displays (2002)

The authors describe test results and magnetic field failure levels for several different CRT (cathode ray tube) displays. They attempted to determine what effects, if any, low line voltage has on the magnetic field susceptibility levels. Personal computer CRTs are shown to be susceptible to 60 Hz magnetic fields as low as 20 milligauss. Color monitors with 60 Hz vertical sweeps are less susceptible to 60 Hz, due to the effects of synchronization. Both types of monitors would be about equally susceptible at 50 Hz, since neither was synchronized to 50 Hz. There appears to be no 'schmoo' effect between low line voltages and magnetic field susceptibility on the units tested.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
TFT‐based, multi‐stage, active pixel sensor for alpha particle detection (2014)

A multi‐stage thin film transistor (TFT)‐based active pixel sensor (APS), capable of successfully detecting small impulses of charge resulting from incident alpha particle strikes, is presented. Detection of alpha particles is important in the field of neutron detection, where fully integrated thin‐film‐based detectors are an attractive alternative to conventional 3 He‐based proportional counters owing to their low‐cost and large‐area scaling capability, combined with the use of readily available materials. A typical TFT process, however, produces only N ‐type devices with low electron mobilities – making high‐gain CMOS amplifier designs unfeasible. The disadvantages of using a TFT‐only APS design are mitigated by cascading multiple low‐gain TFT amplifiers, which results in a higher overall pixel gain – subsequently allowing for the successful detection and readout of alpha particle strikes. Presented is a new APS fabricated in an indium gallium zinc oxide TFT process is presented, and successful initial alpha response measurements are reported.
Adduct Ion (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Ultrathin Co/Pt and Co/Pd superlattice films for MgO-based perpendicular magnetic tunnel junctions (2010)

Ultrathin [Co/Pt]n and [Co/Pd]n superlattice films consisting of 0.14–0.20-nm-thick Co and Pt(Pd) layers were deposited by sputtering. A large perpendicular magnetic anisotropy [(3–9)×106 ergs/cm3] and an ideal square out-of-plane hysteresis loop were attained even for ultrathin superlattice films with a total thickness of 1.2–2.4 nm. The films were stable against annealing up to 370 °C. MgO-based perpendicular magnetic tunnel junctions with this superlattice layer as the free layer showed a relatively high magnetoresistance ratio (62%) and an ultralow resistance-area product (3.9 Ω μm2) at room temperature. The use of these films will enable the development of gigabit-scale nonvolatile memory.
ChemInform Abstract: N‐Phosphonoalkyl‐5‐aminomethylquinoxaline‐2,3‐diones: In vivo Active AMPA and NMDA (Glycine) Antagonists. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Self-consistent kinetic model of the cathode fall of a glow discharge (1989)

The electrons in the cathode-fall (CF) region of a helium dc glow discharge have been modeled at the kinetic level with a self-consistent electric field using a ``convective-scheme'' (CS) (propagator or Green's-function) solution method. The CS is both straightforward to implement and numerically efficient. CS electron calculations using one spatial and two velocity variables are shown to match Monte Carlo simulations of swarms in uniform E/N and in the CF. The CS predictions are also shown to match experimental swarm results. A self-consistent CF solution is obtained through a slow relaxation of the electric field to that indicated by Poisson's equation. The electric field configuration as predicted by the CS agrees well with optogalvanic measurements. The discussion emphasizes both the physical nature of, and the difficulties associated with, a self-consistent-field calculation.
Heterodyne photomixer spectrometer with receiver photomixer driven at different frequency than source photomixer (2023)

A heterodyne photomixer spectrometer comprises a receiver photomixer that is driven at a different frequency than the source photomixer, thereby maintaining the coherent nature of the detection, eliminating etalon effects, and providing not only the amplitude but also the phase of the received signal. The heterodyne technique can be applied where the source and receiver elements are components of a waveguide thereby forming an on-chip heterodyne spectrometer.
Achieving Cinematic Motion With High-Dynamic Range (2021)

<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">This paper explores how the appearance of cinematic motion (the characteristic balance of smoothness and realism of motion commonly used in cinema) is affected by high-dynamic range (HDR) presentation. We report on a psychovisual experiment that investigated how observers rated the comparative smoothness of motion among scenes of different motion types (pans, action, slow movement), frame rates, and luminance levels. We found that to match the level of cinematic motion in today’s non-HDR presentation, the frame rate may need to either remain at 24 frames/sec or be increased to 30 frames/sec, depending on the type of motion and the luminance level of the scene. We conclude that by selecting the appropriate frame rate depending on the motion type in each scene, content creators will be able to achieve a similar cinematic motion without compromising their use of the HDR color palette</i> .
Expression of seprase in effusions from patients with epithelial ovarian carcinoma (2007)

Seprase may be involved in the development of ovarian cancer, and is a potential predictive marker for the disease.
Scalable and ultralow power silicon photonic two-dimensional phased array (2023)

Photonic integrated circuit based optical phased arrays (PIC-OPAs) are emerging as promising programmable processors and spatial light modulators, combining the best of planar and free-space optics. Their implementation on silicon photonic platforms has been especially fruitful. Despite much progress in this field, demonstrating steerable two-dimensional (2D) OPAs that are scalable to a large number of array elements and operate with a single wavelength has proven a challenge. In addition, the phase shifters used in the array for programming the far-field beam are either power hungry or have a large footprint, preventing the implementation of large scale 2D arrays. Here, we demonstrate a two-dimensional silicon photonic phased array with high-speed (∼330 kHz) and ultralow power microresonator phase-shifters with a compact radius (∼3 µm) and 2π phase shift ability. Each phase-shifter consumes an average of ∼250 µW of static power for resonance alignment and ∼50 µW of power for far-field beamforming, a more than one order of magnitude improvement compared to prior OPA works based on waveguide-based thermo-optic phase shifters. Such PIC-OPA devices can enable a new generation of compact and scalable low power processors and sensors.
A-VMCO: A novel forming-free, self-rectifying, analog memory cell with low-current operation, nonfilamentary switching and excellent variability (2015)

We demonstrate a self-rectifying, compliance-free, BEOL CMOS-compatible, resistive switching memory device, with nonfilamentary switching mechanism, forming-free operation, analog switching behavior and excellent device to device operation uniformity, down to the smallest device size. The cells have a reset switching current density of ~0.3MA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> (and ~10× lower set current). This corresponds to ~5uA reset current in a 40nm-size cell, projecting down to 1uA for a 20nm-size. The switching currents are tunable by process and structural cell design. The cells can be operated with pulses as short as 10ns, at below ±7V. Cycling for at least 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> cy and retention of 55°C/3yr are demonstrated, with clear paths for further improvement. These key features are enabled by the use of an amorphous-Silicon (a-Si) barrier layer, which acts as a semi-insulating oxygen scavenger in a dual-layer a-Si/TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> active stack, being able to provide nonlinear IV cell characteristics, as well as to induce a large oxygen vacancy density in the switching layer.
Automatic Taxonomy Induction and Expansion (2019)

Nicolas Rodolfo Fauceglia, Alfio Gliozzo, Sarthak Dash, Md. Faisal Mahbub Chowdhury, Nandana Mihindukulasooriya. Proceedings of the 2019 Conference on Empirical Methods in Natural Language Processing and the 9th International Joint Conference on Natural Language Processing (EMNLP-IJCNLP): System Demonstrations. 2019.
Effect of low-addition soft contact lenses with decentered optical design on myopia progression in children: a pilot study (2014)

This pilot study suggests that low-addition soft CLs with decentered optical design can reduce the degree of axial elongation in myopic children after an initial transient phase of CL wear. The reduction of the progression of myopia by low-addition soft CLs warrants further investigations.
Wavelength optimization in spectral near-infrared optical tomography (2009)

Multi-spectral Near Infrared tomographic imaging has the potential to provide information about patho-physiological function of soft tissue. However, the specific choice of wavelengths used is crucial for the accurate separation of such parameters. It will be demonstrated that the conventionally believed choice of large set of wavelengths can be detrimental in accurate recovery of tissue specific functions. The method of determining a set of optimized bands of wavelengths will be presented and are tested using simulations and experimental data. It will be shown that the optimization method achieves images as accurate as using the full spectrum, but improves crosstalk between parameters. Additionally, a Jacobian normalization technique is presented which takes into account the varying magnitude of different optical parameters within image reconstruction, creating a more uniform update within a spectral image reconstruction model.
Athletes’ brand equity, spectator satisfaction, and behavioral intentions (2019)

Purpose The purpose of this paper is to examine the relationships among an individual athlete’s brand equity, overall spectator satisfaction at sporting events and behavioral intentions. Design/methodology/approach The convenience sampling method was used when approaching potential participants among spectators of the LG Whisen Rhythmic All Stars 2013, a sporting event in which celebrated sports players perform choreographed dance routines. A total of 350 surveys were completed in Go-Yang, South Korea. Of the surveys collected, 20 were discarded due to excessive missing values, resulting in 330 usable surveys. Findings Using structural equation modeling, this study found that the brand equity of an individual athlete positively and directly affects the overall sporting event satisfaction and behavioral intentions, including re-purchase and word-of-mouth intentions among event attendees, which are factors that are mediated indirectly by satisfaction. Originality/value This study shows that the brand equity of an individual athlete can increase the spectator satisfaction levels in a similar manner to the brand equity of a sports team or product.
Extreme group index measured and calculated in 2D SOI-based photonic crystal waveguides (2005)

The paper reports on the measurement and evaluation of the group velocity (GV) dispersion in the proximity of the cutoff wavelength for the fundamental photonic bandgap mode in a 2D photonic crystal waveguide (PCW). The PCW is created by introducing a line defect in an otherwise perfect triangular lattice of air-holes in the 216-nm thick silicon layer in an SOI material. Experimental transmission spectra show a mode cut-off around 1562.5 nm for the fundamental photonic bandgap mode. In order to measure and model the group index of modes in the PCW, a time-of-flight (ToF) method is applied
Five minutes with Prabhakar Raghavan: big data and social science at Google (2012)

Part of PPG’s Impact of Social Sciences project focuses on how academic research in the social sciences influences decision-makers in business, government and civil society. We will cover a series of salient viewpoints emerging from this interview programme on the blog over the next three months. To launch the series Rebecca Mann talked to Prabhakar Raghavan, who is Vice President of Strategic Technologies at Google, and Consulting Professor of Computer Science at Stanford. He explains the role that social scientists are already playing in the development of the tech sector in Silicon Valley, and discusses the opportunities for impact and some remaining obstacles to collaboration.
Further investigations on binaural intelligibility of reverberant speech (2002)

There is a binaural intelligibility advantage for many subjects when listening to reverberant speech. Two processes offer explanations as to why the binaural advantage exists. First, directional information may identify echoes and remove a portion of the reverberation in a manner similar to the precedence effect. A more likely possibility is that the reverberation behaves as additive noise with a specific time and frequency dependence. In this case, subjects may utilize the coherence of the left and right channels to limit the effects of the incoherent reverberation, similar to binaural masking release. To test the latter hypothesis, subjects listen to diotic (L+R), binaural (L&amp;R), and diotic (L or R) reverberant words. The diotic treatment (L+R) adds two recordings measured at the location of the listener’s ears. Since the listener faces the source, the direct signals are coherent while some cancellation is expected for the reverberation. The presentation will compare diotic (L+R) intelligibility to the binaural (L&amp;R) condition as well as the diotic (L or R) control condition where the left or right signal plays to both ears.
ChemInform Abstract: PHOTOCHEMISTRY OF 1,1‐DIAZENES. DIRECT AND SENSITIZED PHOTOLYSES OF N‐(2,2,5,5‐TETRAMETHYLPYRROLIDYL)NITRENE, DL‐N‐(2,5‐DIETHYL‐2,5‐DIMETHYLPYRROLIDYL)NITRENE, AND N‐(2,2,6,6‐TETRAMETHYLPIPERIDYL)NITRENE (1983)

Abstract Die direkte Photolyse der Pyrrolidylnitrene (I) ergibt die Olefine (II), (IV) und (V), die Cyclobutane (III) mit 98‐ bzw. 68‐proz. Konfigurationserhaltung, sowie die Tetrazene (VI), wobei (IIb) als Diastereomerengemisch vorliegt.