gebhart/patrepeval huggingface dataset:
Erratum to: Residual Deformity Is the Most Common Reason for Revision Hip Arthroscopy: A Three-dimensional CT Study (2015)

Erratum to: Clin Orthop Relat Res DOI: 10.1007/s11999-014-4069-9 In the published study, “Residual Deformity Is the Most Common Reason for Revision Hip Arthroscopy: A Three-dimensional CT Study” a coauthor's name is spelled incorrectly. The author's name is Olusanjo Adeoye MD. The authors regret this error.
Compact ${L}$ -Band Relativistic Magnetron With Diffraction Output of TEM Mode (2019)

A compact L -band relativistic magnetron (RM) with the diffraction output (DO) of the TEM mode is proposed. In this DO configuration, a ridged circular waveguide is used to replace the cylindrical waveguide to decrease its radial dimension. The RF field of the operating π-mode is extracted from every resonator cavity and guided to the ridged circular waveguide. Even at the operating frequency of 1.55 GHz, the ridged circular waveguide can reduce the cutoff radius of the RF wave to 73 mm. The output RF field is further effectively converted to the TEM mode by a compact mode converter. Moreover, in the resonant system, a 10-cavity rising-sun slow wave structure (SWS) is applied to lower the phase velocity of the operating spatial harmonic and enhance the mode separation between the operating mode and the adjacent mode. The particle-in-cell (PIC) simulations demonstrate that the practical RM could output a relatively pure TEM mode at the frequency of 1.55 GHz, and its total efficiency is up to 60% with gigawatt radiation power for a diode voltage of 400 kV.
Shadow cameras: Reciprocal views from illumination masks (2009)

Scene appearance from the point of view of a light source is called a reciprocal or dual view. Since there exists a large diversity in illumination, these virtual views may be non-perspective and multi-viewpoint in nature. In this paper, we demonstrate the use of occluding masks to recover these dual views, which we term shadow cameras. We first show how to render a single reciprocal scene view by swapping the camera and light source positions. We extend this technique for multiple views by building a virtual shadow camera array with static masks and a moving source. We also capture non-perspective views such as orthographic, cross-slit and a pushbroom variant, while introducing novel applications such as converting between camera projections and removing refractive and catadioptric distortions. Finally, since a shadow camera is artificial, we can manipulate any of its intrinsic parameters, such as camera skew, to create perspective distortions.
05 The cardioprotective effect of mildronate is associated with decreased CPT I-dependent fatty acid metabolism in mitochondria (2011)

Mildronate is a cardioprotective agent whose mechanism of action is based on decrease in L-carnitine concentration in heart tissue and concomitant decrease in fatty acid metabolism. The present study was undertaken to highlight the role of mitochondrial energy pathways in the anti-infarction mechanism of mildronate. Male Wistar rats received water or mildronate (100 mg/kg, orally) for 14 days. The isolated rat heart ischaemia-reperfusion injury study was performed based on Langerdorff technique. L-carnitine concentration and carnitine palmitoyltransferase I (CPT I) dependent or independent mitochondrial respiration were measured. In addition, the effect of cytochrome c on respiration of saponin-permeabilised cardiac ventricular fibres isolated from ischaemic hearts was determined. Mildronate treatment induced a significant threefold decrease in the L-carnitine concentration in heart tissue and decreased infarct size by 38%. Treatment with mildronate decreased CPT I-dependent mitochondrial respiration on palmitoyl-CoA by 27%, while it had no effect on CPT I-independent respiration on palmitoylcarnitine. Mildronate treatment significantly diminished the ischaemia-induced respiration stimulation by exogenous cytochrome c when pyruvate/malate and succinate were used as respiratory substrates. In conclusion, our results provide evidence that the anti-infarction activity of mildronate is related to decrease in CPT I-dependent fatty acid metabolism. The cardioprotective effect of mildronate could be partially attributed to the maintenance of the integrity of mitochondrial outer membrane.
Steady state plane wave propagation speed in excitable media (1997)

With the view to excitation waves in neuromuscular tissue we study the propagation speed $c$ of steady state plane trigger waves as a function of the shape parameters of the nonlinear source function in the reaction diffusion equation (the slow recovery variable is assumed frozen). The nonlinear eigenvalue problem, which yields $c$ as the eigenvalue and the wave profile $u(\ensuremath{\xi})$ as the eigenfunction, is reformulated to allow us to construct a variety of exactly solvable models, in particular the waves with profiles having central symmetry about their midpoints. Trigger waves with asymmetric profiles are also considered. The propagation speed $c$ is expressed in terms of the shape parameters of the nonlinear source function $i(u).$ We show that among shape parameters of $i(u)$ there are only three essential ones which control the propagation speed. We derive a general expression for the propagation speed, which has the same simple form as in the well known case with the sawtoothwise $i(u)$ but with one parameter appropriately redefined. We also introduce a simple iterative procedure for solving the nonlinear eigenvalue problem. Finally introducing a new exactly solvable model we show that the effect of noninstantaneous activation on the propagation speed can be reduced to renormalization of one of the steady state model's parameter.
Pilote de modulateur optique pour des applications photonique 100 Gbits/s sur silicium (2015)

National audience
Synthesis of high purity metal oxide nanoparticles for optical applications (2014)

In this paper we present our recent research results in synthesizing various metal oxide nanoparticles for use as laser gain media (solid state as well as fiber lasers) and transparent ceramic windows via two separate techniques, co-precipitation and flame spray pyrolysis. The nanoparticles were pressed into ceramic discs that exhibited optical transmission approaching the theoretical limit and showed very high optical-to-optical lasing slope efficiency. We have also synthesized sesquioxide nanoparticles using a Flame Spray Pyrolysis (FSP) technique that leads to the synthesis of a metastable phase of sesquioxide which allows fabricating excellent optical quality transparent windows with very fine grain sizes. Finally, we present our research in the synthesis of rare earth doped boehmite nanoparticles where the rareearth ion is encased in a cage of aluminum and oxygen to prevent ion-ion proximity and energy transfer. The preforms have been drawn into fibers exhibiting long lifetimes and high laser efficiencies.
Stepwise Self‐Assembly of a Protein Nanoarray from a Nanoimprinted Poly(Ethylene Glycol) Hydrogel (2008)

Ultraviolet nanoimprint lithography is used to fabricate nanopatterns of poly(ethylene glycol) (PEG) hydrogel on gold substrates for the construction of protein nanoarrays. A protein nanoarray with a minimum feature size of 100 nm is constructed in the nanowell of the PEG hydrogel by self-assembly with a biotinylated PEG-disulfide, streptavidin, and biotinylated antibody, sequentially (see figure), and confirmed by varying the nanowell height between each step in both solution and air. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2296/2008/z700865_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
GSHADE (2014)

At WAHC'13, Bringer et al. introduced a protocol called SHADE for secure and efficient Hamming distance computation using oblivious transfer only. In this paper, we introduce a generalization of the SHADE protocol, called GSHADE, that enables privacy-preserving computation of several distance metrics, including (normalized) Hamming distance, Euclidean distance, Mahalanobis distance, and scalar product. GSHADE can be used to efficiently compute one-to-many biometric identification for several traits (iris, face, fingerprint) and benefits from recent optimizations of oblivious transfer extensions. GSHADE allows identification against a database of 1000 Eigenfaces in 1.28 seconds and against a database of 10000 IrisCodes in 17.2 seconds which is more than 10 times faster than previous works.
Data from Lithium Treatment Prevents Neurocognitive Deficit Resulting from Cranial Irradiation (2023)

&lt;div&gt;Abstract&lt;p&gt;Curative cancer treatment regimens often require cranial irradiation, resulting in lifelong neurocognitive deficiency in cancer survivors. This deficiency is in part related to radiation-induced apoptosis and decreased neurogenesis in the subgranular zone of the hippocampus. We show that lithium treatment protects irradiated hippocampal neurons from apoptosis and improves cognitive performance of irradiated mice. The molecular mechanism of this effect is mediated through multiple pathways, including Akt/glycogen synthase kinase-3β (GSK-3β) and Bcl-2/Bax. Lithium treatment of the cultured mouse hippocampal neurons HT-22 induced activation of Akt (1.5-fold), inhibition of GSK-3β (2.2-fold), and an increase in Bcl-2 protein expression (2-fold). These effects were sustained when cells were treated with lithium in combination with ionizing radiation. In addition, this combined treatment led to decreased expression (40%) of the apoptotic protein Bax. The additional genes regulated by lithium were identified by microarray, such as &lt;i&gt;decorin&lt;/i&gt; and &lt;i&gt;Birc1f&lt;/i&gt;. In summary, we propose lithium treatment as a novel therapy for prevention of deleterious neurocognitive consequences of cranial irradiation. (Cancer Res 2006; 66(23): 11179-86)&lt;/p&gt;&lt;/div&gt;
ChemInform Abstract: THE SYNTHESIS OF PYRIDOQUINOLINES WITH DIALKYLAMINOPROPYLAMINE SIDE CHAINS (1984)

Abstract Es werden die Dimethylaminopropyl‐pyridochinoline (I)‐(V) hergestellt.
Impact of Process Optimizations on the Electrical Performance of High-k Layers Deposited by Aqueous Chemical Solution Deposition (2008)

Alternative high-k materials are being researched for future dielectrics in various complementary metal oxide semiconductor applications. We report on the aqueous chemical solution deposition technique as an alternative material screening technique. We used ZrO2 as a reference material to explore the effect of different process parameters on the electrical performance of Pt-dot capacitors. We studied the effects of varying the molar ratio between citric acid and the Zr ions, as well as the conditions of the oxidizing postdeposition anneal. We found that proper optimization of these parameters can significantly reduce the amount of carbon in the layers and enhance the electrical performance of the films to similar levels as atomic layer deposition. (C) 2008 The Electrochemical Society.
The specific biochemistry of human axilla odour formation viewed in an evolutionary context (2020)

Human body odour is dominated by the scent of specific odourants emanating from specialized glands in the axillary region. These specific odourants are produced by an intricate interplay between biochemical pathways in the host and odour-releasing enzymes present in commensal microorganisms of the axillary microbiome. Key biochemical steps for the release of highly odouriferous carboxylic acids and sulfur compounds have been elucidated over the past 15 years. Based on the profound molecular understanding and specific analytical methods developed, evolutionary questions could be asked for the first time with small population studies: (i) a genetic basis for body odour could be shown with a twin study, (ii) no effect of genes in the human leukocyte antigen complex on the pattern of odourant carboxylic acid was found, and (iii) loss of odour precursor secretion by a mutation in the <i>ABCC11</i> gene could explain why a large fraction of the population in the Far East lack body odour formation. This review summarizes what is currently known at the molecular level on the biochemistry of the formation of key odourants in the human axilla. At the same time, we present for the first time the crystal structure of the <i>N</i><sub>α</sub>-acyl-aminoacylase, a key human odour-releasing enzyme, thus describing at the molecular level how bacteria on the skin surface have adapted their enzyme to the specific substrates secreted by the human host. This article is part of the Theo Murphy meeting issue 'Olfactory communication in humans'.
A novel vertical bottom-gate polysilicon thin film transistor with self-aligned offset (1996)

A novel device structure for the vertical bottom polysilicon gate thin film transistor (TFT) with a self-align offset drain is proposed and demonstrated. The new VTFT allows a deep-submicron channel length, which is determined by the thickness of the active polysilicon film, not by the lithographic system resolution. The self-alignment offset drain reduces the leakage current, as a result, it exhibits good device performance.
Simultaneous and exact interval estimates for the contrast of two groups based on an extremely high dimensional variable: application to mass spec data (2007)

R-package, 'seie.zip' (license: GNU GPL), is publiclly available at http://research2.dfci.harvard.edu/dfci/MS_spike-in_data/
Industrial Scale Manufacturing and Downstream Processing of PLGA-Based Nanomedicines Suitable for Fully Continuous Operation (2022)

Despite the efficacy and potential therapeutic benefits that poly(lactic-co-glycolic acid) (PLGA) nanomedicine formulations can offer, challenges related to large-scale processing hamper their clinical and commercial development. Major hurdles for the launch of a polymeric nanocarrier product on the market are batch-to-batch variations and lack of product consistency in scale-up manufacturing. Therefore, a scalable and robust manufacturing technique that allows for the transfer of nanomedicine production from the benchtop to an industrial scale is highly desirable. Downstream processes for purification, concentration, and storage of the nanomedicine formulations are equally indispensable. Here, we develop an inline sonication process for the production of polymeric PLGA nanomedicines at the industrial scale. The process and formulation parameters are optimized to obtain PLGA nanoparticles with a mean diameter of 150 ± 50 nm and a small polydispersity index (PDI < 0.2). Downstream processes based on tangential flow filtration (TFF) technology and lyophilization for the washing, concentration, and storage of formulations are also established and discussed. Using the developed manufacturing and downstream processing technologies, production of two PLGA nanoformulations encasing ritonavir and celecoxib was achieved at 84 g/h rate. As a measure of actual drug content, encapsulation efficiencies of 49.5 ± 3.2% and 80.3 ± 0.9% were achieved for ritonavir and celecoxib, respectively. When operated in-series, inline sonication and TFF can be adapted for fully continuous, industrial-scale processing of PLGA-based nanomedicines.
Context-specificity in causal signaling networks revealed by phosphoprotein profiling (2016)

Summary Signaling networks downstream of receptor tyrosine kinases are among the most extensively studied biological networks. However, it remains unclear whether signaling networks depend on biological context. Signaling networks encode causal influences – and not just correlations – between network components. Here, using a causal framework and systematic time-course assays of signaling proteins, we investigate the context-specificity of signaling networks in a cell line system. We focus on a well-defined set of signaling proteins profiled in four breast cancer cell lines under eight stimulus conditions and inhibition of specific kinases. The data, spanning multiple pathways and comprising approximately 70,000 phosphoprotein and 260,000 protein measurements, provide a wealth of testable, context-specific hypotheses, several of which we validate in independent experiments. Furthermore, the data provide a resource for computational methods development, permitting empirical assessment of causal network learning in a complex, mammalian setting.
Behavior-oriented data resource management in medical sensing systems (2013)

Wearable sensing systems have recently enabled a variety of medical monitoring and diagnostic applications in wireless health. The need for multiple sensors and constant monitoring leads these systems to be power hungry and expensive with short operating lifetimes. We introduce a novel methodology that takes advantage of contextual and semantic properties in human behavior to enable efficient design and optimization of such systems from the data and information point of view. This, in turn, directly influences the wireless communication and local processing power consumption. We exploit intrinsic space and temporal correlations between sensor data while considering both user and system contextual behavior. Our goal is to select a small subset of sensors that accurately capture and/or predict all possible signals of a fully instrumented wearable sensing system. Our approach leverages novel modeling, partitioning, and behavioral optimization, which consists of signal characterization, segmentation and time shifting, mutual signal prediction, and a simultaneous minimization composed of subset sensor selection and opportunistic sampling. We demonstrate the effectiveness of the technique on an insole instrumented with 99 pressure sensors placed in each shoe, which cover the bottom of the entire foot, resulting in energy reduction of 72% to 97% for error rates of 5% to 17.5%.
Glycoside‐specific glycosyltransferases catalyze regio‐selective sequential glucosylations for a sesame lignan, sesaminol triglucoside (2019)

Sesame (Sesamum indicum) seeds contain a large number of lignans, phenylpropanoid-related plant specialized metabolites. (+)-Sesamin and (+)-sesamolin are major hydrophobic lignans, whereas (+)-sesaminol primarily accumulates as a water-soluble sesaminol triglucoside (STG) with a sugar chain branched via β1→2 and β1→6-O-glucosidic linkages [i.e. (+)-sesaminol 2-O-β-d-glucosyl-(1→2)-O-β-d-glucoside-(1→6)-O-β-d-glucoside]. We previously reported that the 2-O-glucosylation of (+)-sesaminol aglycon and β1→6-O-glucosylation of (+)-sesaminol 2-O-β-d-glucoside (SMG) are mediated by UDP-sugar-dependent glucosyltransferases (UGT), UGT71A9 and UGT94D1, respectively. Here we identified a distinct UGT, UGT94AG1, that specifically catalyzes the β1→2-O-glucosylation of SMG and (+)-sesaminol 2-O-β-d-glucosyl-(1→6)-O-β-d-glucoside [termed SDG(β1→6)]. UGT94AG1 was phylogenetically related to glycoside-specific glycosyltransferases (GGTs) and co-ordinately expressed with UGT71A9 and UGT94D1 in the seeds. The role of UGT94AG1 in STG biosynthesis was further confirmed by identification of a STG-deficient sesame mutant that predominantly accumulates SDG(β1→6) due to a destructive insertion in the coding sequence of UGT94AG1. We also identified UGT94AA2 as an alternative UGT potentially involved in sugar-sugar β1→6-O-glucosylation, in addition to UGT94D1, during STG biosynthesis. Yeast two-hybrid assays showed that UGT71A9, UGT94AG1, and UGT94AA2 were found to interact with a membrane-associated P450 enzyme, CYP81Q1 (piperitol/sesamin synthase), suggesting that these UGTs are components of a membrane-bound metabolon for STG biosynthesis. A comparison of kinetic parameters of these UGTs further suggested that the main β-O-glucosylation sequence of STG biosynthesis is β1→2-O-glucosylation of SMG by UGT94AG1 followed by UGT94AA2-mediated β1→6-O-glucosylation. These findings together establish the complete biosynthetic pathway of STG and shed light on the evolvability of regio-selectivity of sequential glucosylations catalyzed by GGTs.
Templated synthesis enhances the cobalt adsorption capacity of a porous organic polymer (2021)

Divalent transition metals such as Co(II) are important targets for removal from water sources, due to their potential toxicity as well as their high value. In this study, we found that a series of porous organic polymers based on amide-linked tetraphenylmethane units are effective Co(II) ion adsorbents in aqueous solution. To increase the density of Co(II) binding sites, we then developed a templated synthesis in which the branched, rigid monomers are pre-assembled around Co(II) ions prior to polymerization. After polymer formation, the Co(II) template ions are removed to yield a material rich in Co(II) binding sites. Ion adsorption isotherms show that the Co(II)-templated material has an ion adsorption capacity significantly greater than those of the non-templated materials, highlighting the utility of a templated synthetic route. SEM and TEM images show the morphology of the templated polymer to be dramatically different from the non-templated polymers and to be similar in size and shape to the Co(II)-monomer precursors, emphasizing the role of the template ions in directing the formation of the resulting polymer. This guest-templated approach requires no functionalization of the generic monomer and represents a promising synthetic route to high-capacity ion adsorbents for water purification and aqueous separations.
Ultimately low-loss and compact Si wire 90° waveguide bend composed of clothoid and normal curves for dense optical interconnect PICs (2017)

Ultimately low-loss 90° waveguide bend composed of clothoid and normal curves is proposed for dense optical interconnect PICs. 90 % reduction of the bending loss is experimentally demonstrated with excellent agreement between theory and experiment.
Serum antibody response to oral infection precedes but does not prevent Porphyromonas gingivalis–induced alveolar bone loss in mice (1999)

The purpose of this study was to determine whether humoral immunity prevents bacterially induced alveolar bone loss. BALB/cByJ mice were orally infected with the human periodontopathic bacterium Porphyromonas gingivalis, and were compared with sham-infected mice. Specific serum antibody titers to P. gingivalis were measured by enzyme-linked immunosorbent assay. Alveolar bone levels were measured as the distance from the cementoenamel junction to the alveolar bone crest and bone loss was defined as a change in bone levels over time or between infected and sham-infected animals. The specific humoral response was predominantly of the IgG isotype, although low levels of specific serum IgA were also present. Antibody titers in the infected animals were significantly different from those in the sham-infected animals by 18 days and remained at maximal levels at 47 days. Bone loss became significant by 26 days and continued to progress at 47 days. Thus the serum antibody response to oral infection with P. gingivalis preceded detectable bone loss and remained elevated while bone loss increased. The presence of specific antibody did not prevent the onset or progression of bone loss.