gebhart/patrepeval huggingface dataset:
Learning Generative Models of Shape Handles (2020)

We present a generative model to synthesize 3D shapes as sets of handles -- lightweight proxies that approximate the original 3D shape -- for applications in interactive editing, shape parsing, and building compact 3D representations. Our model can generate handle sets with varying cardinality and different types of handles. Key to our approach is a deep architecture that predicts both the parameters and existence of shape handles and a novel similarity measure that can easily accommodate different types of handles, such as cuboids or sphere-meshes. We leverage the recent advances in semantic 3D annotation as well as automatic shape summarization techniques to supervise our approach. We show that the resulting shape representations are not only intuitive, but achieve superior quality than previous state-of-the-art. Finally, we demonstrate how our method can be used in applications such as interactive shape editing and completion, leveraging the latent space learned by our model to guide these tasks.
Exploring Crowdsourcing for Subjective Quality Assessment of 3D Graphics (2021)

Multimedia subjective quality assessment experiments are the most prominent and reliable way to evaluate the visual quality as perceived by human observers. Along with laboratory (lab) subjective experiments, crowdsourcing (CS) experiments have become very popular in recent years, e.g., during the COVID-19 pandemic these experiments provide an alternative to lab tests. However, conducting subjective quality assessment tests in CS raises many challenges: internet connection quality, lack of control on participants’ environment, participants’ consistency and reliability, etc. In this work, we evaluate the performance of CS studies for 3D graphics quality assessment To this end, we conducted a CS experiment based on the double stimulus impairment scale method and using a dataset of 80 meshes with diffuse color information corrupted by various distortions. We compared its results with those previously obtained in a lab study conducted on the same dataset and in a virtual reality environment. Results show that under controlled conditions and with appropriate participant screening strategies, a CS experiment can be as accurate as a lab experiment.
Enhancement of Static and Dynamic Sag Performance of Water-Based Mud Using a Synthetic Clay (2021)

Fluid homogeneity and stability are of high importance as they greatly affect the fluid performance in drilling operations. Solid settlement or solid sag is a severe issue that occurs in weighted drilling muds, especially at elevated temperatures, where the weight material tends to settle down causing well control problems. This study evaluates the effectiveness of a synthetic clay (laponite) to prevent the static and dynamic sag tendency of barite-weighted drilling fluid for elevated-temperature drilling applications. Several high-density mud samples were prepared by varying the concentration of the synthetic clay. The sag tendency of the fluid samples was evaluated in the lab using dynamic and static sag tests, and the optimal concentration was determined. The impact of synthetic clay on the density, pH, and rheological properties was also studied. Moreover, the filtration properties of the developed formulation were measured using high-pressure high-temperature filtration experiments. The synthetic clay was found to be effective in reducing the static and dynamic sag tendency of barite-weighted water-based drilling fluids. 0.75 lb/bbl of laponite was adequate to eliminate solid sag at a temperature up to 250 F. This amount of laponite slightly increased the plastic viscosity by 8%, while an increase of 42% and 43-115% in the yield point and gel strength, respectively, was observed. A significant enhancement in the filtration performance was observed; the filter cake thickness and the filtrate volume were decreased by 15-20%. Additionally, the synthetic clay had an insignificant effect on the fluid density and pH.
Constitutive Expression of Enniatin Synthetase during Fermentative Growth of Fusarium scirpi (1988)

The production of enniatins by Fusarium scirpi during fermentative growth in submerged cultures was measured. The fungus produced the antibiotic during mycelial growth, but not during the stationary phase of cultivation. By contrast, enniatin synthetase, the enzyme responsible for enniatin synthesis, was present during growth, during the stationary phase, and even in spores. Similarly, the enniatin synthetase mRNA was present at every stage of the cultivation of the fungus. Therefore, this multifunctional peptide synthetase is a constitutive enzyme, the expression of which is not regulated by any specific mechanism. The findings stand in contrast to the common assumption that production of secondary metabolites underlies regulatory control, leading to separation of the trophophase and the idiophase.
Keratinocyte Migration in the Developing Eyelid Requires LIMK2 (2012)

In vitro studies have identified LIMK2 as a key downstream effector of Rho GTPase-induced changes in cytoskeletal organization. LIMK2 is phosphorylated and activated by Rho associated coiled-coil kinases (ROCKs) in response to a variety of growth factors. The biochemical targets of LIMK2 belong to a family of actin binding proteins that are potent modulators of actin assembly and disassembly. Although numerous studies have suggested that LIMK2 regulates cell morphology and motility, evidence supportive of these functions in vivo has remained elusive. In this study, a knockout mouse was created that abolished LIMK2 biochemical activity resulting in a profound inhibition of epithelial sheet migration during eyelid development. In the absence of LIMK2, nascent eyelid keratinocytes differentiate and acquire a pre-migratory phenotype but the leading cells fail to nucleate filamentous actin and remain immobile causing an eyes open at birth (EOB) phenotype. The failed nucleation of actin was associated with significant reductions in phosphorylated cofilin, a major LIMK2 biochemical substrate and potent modulator of actin dynamics. These results demonstrate that LIMK2 activity is required for keratinocyte migration in the developing eyelid.
Realisierung eines Smartphone-basierten auditiven Feedbacks zur unterstützenden Stotterbehandlung (2012)

In der Stotterbehandlung wird mitunter therapiebegleitend das auditive Feedback eingesetzt. Dabei wird die Stimme des Patienten verzogert und transponiert uber Kopfhorer zuruckgekoppelt. Der vorliegende Beitrag stellt ein Projekt vor, bei dem das auditive Feedback auf Android-Smartphones realisiert wurde. Die Anwendung nimmt das Audiosignal vom eingebauten Mikrofon auf, entrauscht es, verfremdet es wahlweise und gibt es mit Verzogerung am angeschlossenen Kopfhorer aus. Zur Stimmverfremdung wurden Effekte wie Transposition, Roboter- und Flusterstimme auf einer gemeinsamen Implementierungsbasis umschaltbar realisiert. Zur Reduzierung des Grundrauschpegels wurde eine einfache Rauschunterdruckung integriert. Zur Erhaltung der aufgrund der Transposition veranderten Formantenlagen wurde ein LPC-Verfahren untersucht. Beschrieben werden hier die eingesetzten Algorithmen und deren Softwareumsetzung sowie Erkenntnisse bezuglich der Hardwareanforderungen, der vorgenommenen Laufzeitoptimierung und der API-bedingten Verz¨ogerungszeiten bei der Audioausgabe.
Thick Piezoelectric Films from Laser Transfer Process (2006)

This chapter contains sections titled: Introduction Screen Printing Laser Transfer Process Experimental Procedure Results and Discussions Summary
Control of fine particulate and gaseous contaminants by UV/photoelectron method (2002)

In semiconductor manufacturing processes, surface contamination is a very important issue because it decreases the product yield of the LSI. In this study, a new method to remove fine airborne particles and gaseous contaminants in the wafer stocker using a UV/photoelectron method has been investigated. Two kinds of wafer stockers are used for investigating the efficiency of the UV/photoelectron method for controlling (1) particulate and gaseous contaminants under atmospheric conditions and (2) particulate contaminants under low pressure conditions.
Effects of increased voltage on resolution in preparative isoelectric focusing of myoglobin varia (2006)

IEF is a powerful technique which separates proteins and other amphoteric solutes in a pH gradient according to their pI's. The current work evaluates the effect on resolution of increasing electric fields in a novel preparative, vortex-stabilized electrophoresis device. In shallow gradients spanning one pH unit, the variants of myoglobin were separated at applied voltages from 10 to 15 kV. Digital imaging of these separations indicated a 20% reduction in bandwidth and a 60% increase in resolution as the electric field strength is varied across this range. These results were confirmed by IEF-PAGE and ion-exchange chromatography.
Clinical evaluation of neuroinflammation in child-onset focal epilepsy: a translocator protein PET study (2021)

This study indicates that [<sup>11</sup>C] DPA713 uptake has valuable sensitivity in the identification of epileptic foci in child-onset focal epilepsy, and inflammation is implicated in the pathophysiology in the epileptic foci caused by various etiologies. Further research is required to establish diagnostic tools for identifying focal epileptogenic zones.
Evaluation of back end of line structures underneath wirebond pads in ultra low-k device (2012)

Mechanical integrity of back end of line structures underneath wirebond pads was evaluated using 32 nm ultra low-k device by wire pull testing and 3D finite element analysis. Pad tearout rate at wire pull testing was measured for various Cu line/via structures. One key factor for robust bond pads is effective modulus in ULK levels. In addition, increased via and wiring metal density reduces the risk of pad tearout. For the evaluated structures in this work, a calculated effective modulus in ULK was a better index than metal layout type for assessment of bond pad robustness in cooperation with finite element analysis data. Wirebonding is another key factor affecting pad tearout. In this work, effects of wirebond geometry (i.e. wire size and bond ball size) on pad tearout were focused rather than the effect of parameter itself. With the robust BEOL stack and appropriate wirebonding conditions, module level reliability of 35 μm ultra fine pitch wirebond on ultra low-k chip with circuit underneath bond pads was also demonstrated with a PBGA package.
ChemInform Abstract: FREE‐RADICAL ADDITIONS TO OLEFINS IN THE PRESENCE OF REDOX SYSTEMS (1975)

Abstract Übersicht.
Identification of Five Interferon-Induced Cellular Proteins That Inhibit West Nile Virus and Dengue Virus Infections (2010)

Interferons (IFNs) are key mediators of the host innate antiviral immune response. To identify IFN-stimulated genes (ISGs) that instigate an antiviral state against two medically important flaviviruses, West Nile virus (WNV) and dengue virus (DENV), we tested 36 ISGs that are commonly induced by IFN-alpha for antiviral activity against the two viruses. We discovered that five ISGs efficiently suppressed WNV and/or DENV infection when they were individually expressed in HEK293 cells. Mechanistic analyses revealed that two structurally related cell plasma membrane proteins, IFITM2 and IFITM3, disrupted early steps (entry and/or uncoating) of the viral infection. In contrast, three IFN-induced cellular enzymes, viperin, ISG20, and double-stranded-RNA-activated protein kinase, inhibited steps in viral proteins and/or RNA biosynthesis. Our results thus imply that the antiviral activity of IFN-alpha is collectively mediated by a panel of ISGs that disrupt multiple steps of the DENV and WNV life cycles.
Hand-Gesture Computing for the Hearing and Speech Impaired (2008)

An instrumented data glove with a wireless interface provides convenient and natural human- computer interaction for people with speech or hearing impairments.
O1‐05‐04: An amyloid‐beta oligomer epitope specific for toxic assemblages in Alzheimer's disease (2015)

Oligomers of the amyloid-beta (Aβ) peptide play key roles in neurotoxicity and region-to-region spreading of Alzheimer's disease (AD) neuropathology. We have previously presented data describing a novel immunological epitope that is accessible to antibody binding only when Aβ is in an oligomeric form. The oligomer-specific epitope consists of a constrained turn at residues 26-28: cyclized serine-asparagine-lysine (cSNK). We now present data indicating that 1) cSNK epitope is specific to toxic oligomers; 2) that passive infusion of cSNK antibodies reduces brain and CSF Aβ oligomers; and 3) cSNK active immunization generates an immune response to Aβ oligomers. Specificity of a murine monoclonal antibody raised against the cSNK epitope, 5E3, was evaluated by immunoelectron microscopy, surface plasmon resonance, dot blotting/immunoblotting, immunohistochemistry, and atomic force microscopy. Therapeutic potential of the 5E3 antibody was assessed in in vivo assays of oligomer behavioral toxicity and acute treatment of aged AD mouse models. Immune responses elicited by cSNK vaccine formulations were evaluated in young mice. cSNK vaccination was assessed in AD mouse models treated at 3 months of age with monthly vaccination and then evaluated at 13 months of age. A monoclonal antibody raised against this novel epitope (5E3) binds to synthetic Aβ oligomers (AβO), but is unreactive to monomeric and fibrillar Aβ, as well as to amyloid plaques. 5E3 is effective at blocking AβO behavioural toxicity in vivo in wild type mice. Moreover acute treatment with 5E3 reduced AβO concentration in CSF and brains of aged APP/PS1 and Tg2576 mice, with no apparent impact on pre-existing plaques. Furthermore, cSNK-vaccinated mice produced an AβO specific immune response, without cross-reactivity to Aβ monomers. These experiments demonstrate three important findings: 1) murine 5E3 can neutralize the toxicity of synthetic AβOs in the molecular weight range of AβOs previously implicated in synaptic dysfunction; 2) systemically administered 5E3 demonstrates target engagement for AβOs in two mouse models of Alzheimer disease in vivo; and 3) active vaccination with the cSNK epitope generates AβO reactivity in mice without recognition of other Aβ molecular species. Together, our data demonstrates that cSNK is a well-defined AβO-specific epitope with therapeutic potential.
A Sense Oligonucleotide Specifically Reverses the Prothrombin Depletion and Anticoagulation Caused by ISIS 401025, an Antisense Oligonucleotide Targeting Prothrombin RNA in Mice. (2007)

Abstract The ability to safely and effectively neutralize anticoagulant activity is of particular importance in the case of long acting drugs. While antisense oligonucleotides (ASOs) benefit from their slow clearance rate from liver (t1/2 approx 10 days in mice) which permits infrequent dosing, the potential necessity to reverse ASO drug activity presents a challenge. ISIS 401025 is a second generation ASO targeting prothrombin RNA that has previously been shown to reduce thrombin generation and prolong PT and aPTT as a result of depleting prothrombin mRNA levels in mice. To explore the possibility of developing an “antidote” strategy for ASO-mediated anticoagulation, we designed a sense oligonucleotide, ISIS 405277, complementary to the ISIS 401025 sequence and examined its ability to reverse the effects of prior treatment with ISIS 401025 in mice. A PT-INR of 3.0 was established after 3 weeks of treatment with ISIS 401025 at a weekly dose of 60 mg/kg, corresponding to a reduction of prothrombin mRNA transcript levels of 96%. A single injection of the sense oligonucleotide, ISIS 405277, resulted in a dose-dependent reversal of INR to 1.6, 1.1, and 0.9 three days after injection of 30, 60, and 90 mg/kg, respectively. Corresponding prothrombin transcript levels in liver tissue were returned to 18.4%, 27.8%, and 38.9% of normal levels, respectively. Results from a study designed to determine the kinetics of reversal of anticoagulation indicated that a 50% reduction of PT-INR 4.3, established following 3 weeks of treatment with ISIS 401025, required 11 days in the absence of subsequent treatment, while the reduction was achieved in 2.2 days following a single administration of 90 mg/kg of sense oligonucleotide. When mice were pretreated with an ASO targeting prothrombin that was not complementary to the sense oligonucleotide (ISIS 40527), sense oligonucleotide treatment was unable to reverse either target depletion or anticoagulation, indicating a sequence-specific antidote effect. These results demonstrate for the first time that subsequent administration of a sense strand oligonucleotide can neutralize ASO mediated target RNA degradation in animals, and demonstrates its potential utility in reversing ASO-based activity for anticoagulation.
Field Implementation of DuPont's Microbial Enhanced Oil Recovery Technology (2012)

Abstract For the last 7 years DuPont with different partners has done research into the application of Microbial Enhanced Oil Recovery technology (MEOR). In laboratory tests, we have observed in excess of 15% increased recovery factor. This exceeded our expectations. In a field test, described in this paper, we have observed a ~15–20% increase in production rate. After extensive fundamental research (5) we have learned many critical aspects of microbial EOR. We have demonstrated two mechanisms that exceeded, in the lab, the targeted increase in the recovery factor. Improved sweep efficiency by plugging of high permeable zones thereby forcing water to produce oil from previously unswept parts of the reservoir. Reduced oil / rock surface tension resulting in a change in the wettabilty of the rock and lower residual oil saturation. This paper describes the field data used to demonstrate the effectiveness of the improved sweep efficiency by using a microbe to plug high permeable zones in a target reservoir - called bioplugging. Our approach has been to inoculate the reservoir with a microbe that under the optimal nutrient conditions will express the needed function - in this case bioplugging for improved sweep efficiency. The microbe and the nutrients are tailored to the conditions of each reservoir thus giving MEOR the greatest chance for success. We have tested the efficacy of the microbial treatment with a series of slim tube tests and interwell tests. Our experience with field implementation has taught us important lessons on how to inoculate and feed microbes in an oil reservoir at a scale needed to support the commercial implementation. Issues that had to be address include assuring the effectiveness of the treatment using realistic lab tests, assuring that the treatments do not bypass the reservoir, assuring that the reservoir is not blinded by the inoculation, and understanding the effects of biocides and corrosion inhibitors that are commonly used in the oil field. Production data for the pilot test has shown a change in the decline curve indicating a significant increase in oil production rate and a corresponding decrease in water cut. Oil production has increased in the field by 15 to 20% with a corresponding reduction in water cut. Our ongoing research has provided many insights into the appropriate application of microbial EOR. The unique aspects of each production area, the nature of the oil, the water, the formation matrix, and the background microbial population and their complex interactions must all be assessed when considering the potential application of microbial EOR. The amount of work described for assessing potential MEOR mechanisms is extensive. However, this process has been streamlined and we have been able to assess new target reservoirs for potential MEOR treatments quickly. We believe that Microbial Enhanced Oil Recovery has the potential to improve the recovery of oil with very low capitol investment and a much smaller environmental footprint compared to other EOR techniques.
Hypochlorous Acid: From Innate Immune Factor and Environmental Toxicant to Chemopreventive Agent Targeting Solar UV-Induced Skin Cancer (2022)

A multitude of extrinsic environmental factors (referred to in their entirety as the 'skin exposome') impact structure and function of skin and its corresponding cellular components. The complex (i.e. additive, antagonistic, or synergistic) interactions between multiple extrinsic (exposome) and intrinsic (biological) factors are important determinants of skin health outcomes. Here, we review the role of hypochlorous acid (HOCl) as an emerging component of the skin exposome serving molecular functions as an innate immune factor, environmental toxicant, and topical chemopreventive agent targeting solar UV-induced skin cancer. HOCl [and its corresponding anion (OCl<sup>-</sup>; hypochlorite)], a weak halogen-based acid and powerful oxidant, serves two seemingly unrelated molecular roles: (<i>i)</i> as an innate immune factor [acting as a myeloperoxidase (MPO)-derived microbicidal factor] and (<i>ii</i>) as a chemical disinfectant used in freshwater processing on a global scale, both in the context of drinking water safety and recreational freshwater use. Physicochemical properties (including redox potential and photon absorptivity) determine chemical reactivity of HOCl towards select biochemical targets [i.e. proteins (e.g. IKK, GRP78, HSA, Keap1/NRF2), lipids, and nucleic acids], essential to its role in innate immunity, antimicrobial disinfection, and therapeutic anti-inflammatory use. Recent studies have explored the interaction between solar UV and HOCl-related environmental co-exposures identifying a heretofore unrecognized photo-chemopreventive activity of topical HOCl and chlorination stress that blocks tumorigenic inflammatory progression in UV-induced high-risk SKH-1 mouse skin, a finding with potential implications for the prevention of human nonmelanoma skin photocarcinogenesis.
Homeomorphic decomposition of the 6th order non-linear model of human movement (1988)

The sixth-order nonlinear model of human movement originally put forward by G. Cook and L. Stark (1968) has a long history of illuminating control problems associated with agonist-antagonist-based movement. It consists of muscle models of the agonist and antagonist which feature a nonlinear viscous element which stimulates A.V. Hill's force-velocity property, and a linear second-order system representing the load of 'plant' being driven, such as the eyeball, head, or arm. A new state-space formulation of the model combines homeomorphism (the property of isomorphism to physiology and anatomy) with mathematical elegance. The model is applied to the problem of control of fast voluntary human movements driven by a triphasic control signal.< <ETX>&gt;</ETX>
Synthesis and Opioid Activity of [Sar4]Dermorphin-Tetrapeptide Analogues (1984)

The modification of the dermorphin-(1-4)-tetrapeptide structure led to analogues with potent opioid activity in vitro and in vivo. [Sar4]Tetrapeptides such as H2N-CH(NH)-Tyr-D-Ala-Phe-Sar-D-NH-CH(CH3)C6H5 (VII) whose terminal amino group is replaced by the guanidino function and whose C-terminus is amidated by (R)-(+)-alpha-methylbenzylamine, show peripheral and central opioid activities comparable to or higher than those of dermorphin. The potency of VII in the different tests was as follows: guinea-pig ileum (GPI) IC50 = 0.09nM, mouse Vas deferens (MVD) IC50 = 0.69nM, tail-flick ED50 = 8.91 pmol/mouse, i.c.v. and 4.54 mumol/kg, s.c. This dermorphin-(1-4)-tetrapeptide derivative is about 650 and 950 times as active as morphine in the two in vitro tests, respectively. The MVD/GPI potency ratio of the new peptides suggests a mu-type agonist behaviour.