gebhart/patrepeval huggingface dataset:
A Transcriptomic Severity Metric That Predicts Clinical Outcomes in Critically Ill Surgical Sepsis Patients (2021)

The Inflammatix-Severity-2 severity score was superior at predicting secondary infections and overall adverse clinical outcomes compared with other common metrics. Combining a rapidly measured transcriptomic metric with clinical or physiologic indices offers the potential to optimize risk-based resource utilization and patient management adjustments that may improve outcomes in surgical sepsis. Hospitalized patients who are septic and present with an elevated IMX-SEV2 severity score and preexisting comorbidities may be ideal candidates for clinical interventions aimed at reducing the risk of secondary infections and adverse clinical outcomes.
A 130 Mb/s PRML read/write channel with digital-servo detection (2002)

The detection of servo information in hard disk drive read channels has traditionally been implemented with analog circuits and converted with an off-chip analog-to-digital converter (ADC). The benefits of digital servo detection include system cost savings through the elimination of the off-chip ADC, reduced development time, repeatability, testability, and ease of future integration. The full digital PRML chip is described.
Model networks based on poly(1,3‐dioxolane) (1990)

Abstract Polyurethane networks whose elastic chains are constituted of hydrophilic poly(1,3‐dioxolane) of well‐defined molecular weight were synthesized using an end‐linking process. The poly(1,3‐dioxolane) (PDXL) precursor polymers, fitted with OH functions at both chain ends, were prepared cationically in the presence of ethylene glycol. The latter compound is involved in the initiation reaction and provides the OH functions at the chain ends. The end‐linking process, leading to the formation of the poly(1,3‐dioxolane) network, involves the reaction of the precursor with a stoichiometric amount of a plurifunctional isocyanate, under conditions that minimize defects. The swelling behavior of the poly(1,3‐dioxolane) networks is compared with that of poly(ethylene oxide) networks previously studied.
Memristor PUF&#x2014;A Security Primitive: Theory and Experiment (2015)

Physical unclonable functions (PUFs) have emerged as a promising hardware security primitive, but existing CMOS PUFs suffer from issues related to reliability and susceptibility to modeling attacks. Memristors, leveraging nanotechnology fabrication process and highly nonlinear behavior, pose as an interesting alternative. In this paper, we report the first demonstration of memristor based PUFs. The six memristors we fabricated show a 50% uncertainty of PUF response and high reliability upon repeated interrogation. A physics based circuit model of memristors was also implemented to accurately determine the simulation time required for randomly selected polyominoes from a 3-D array of memristors. The proposed model provides higher degree of complexity and results in seven orders of increase in simulation time for an attacker than that reported by Rajendran , 2012.
Synthesis and Relaxometric Studies of a Dendrimer‐Based pH‐Responsive MRI Contrast Agent (2008)

The design of effective pH responsive MRI contrast agents is a key goal in the development of new diagnostic methods for conditions such as kidney disease and cancer. A key factor determining the effectiveness of an agent is the difference between the relaxivity of the "on" state compared to that of the "off" state. In this paper, we demonstrate that it is possible to improve the pH-responsive action of a low molecular weight agent by conjugating it to a macromolecular construct. The synthesis of a bifunctional pH responsive agent is reported. As part of that synthetic pathway we examine the Ing-Manske reaction, identifying an undesirable by-product and establishing effective conditions for promoting a clean and effective reaction. Reaction of the bifunctional pH responsive agent with a G5-PAMAM dendrimer yielded a product with an average of 96 chelates per dendrimer. The relaxivity of the dendrimer conjugate rises from 10.8 mM(-1) s(-1) (pH 9) to 24.0 mM(-1) s(-1) (pH 6) per Gd(3+) ion. This more than doubles the relaxivity pH response, Deltar(1), of our agent from just 51 % for the original low molecular weight chelate to 122 % for the dendrimer.
Fast mutual exclusion by the Triangle algorithm (2017)

Summary This paper presents a new starvation‐free software algorithm for the N ‐thread mutual‐exclusion problem. In the absence of contention, the algorithm requires only eight write and four read operations to enter and leave the critical section; to the best of our knowledge, this is optimal. For algorithms with starvation , five write and two read read operations are optimal. In the presence of contention, the algorithm has excellent performance comparable to the best‐known software solutions using only atomic load and store and to a hardware‐assisted lock (MCS) using stronger atomic primitives and used within the Linux kernel. It is rare for software‐only algorithms for mutual exclusion to perform well for both minimal and maximal contention workloads, making the new algorithm largely self‐tuning when exposed to swings in access patterns.
Autopilot (2020)

In many public and private Cloud systems, users need to specify a limit for the amount of resources (CPU cores and RAM) to provision for their workloads. A job that exceeds its limits might be throttled or killed, resulting in delaying or dropping end-user requests, so human operators naturally err on the side of caution and request a larger limit than the job needs. At scale, this results in massive aggregate resource wastage.
Contextual Recognition (2016)

In this chapter we move beyond the primary theme of recognition and begin to understand what the next level of understanding looks like. Specifically, we will discuss the concept of "context" and contextual understanding. In simple terms, context refers to the environment under which we are trying to understand something.
Renewable Energy Devices and Systems – State-of-the-Art Technology, Research and Development, Challenges and Future Trends (2015)

In this paper, essential statistics demonstrating the increasing role of renewable energy generation are firstly discussed. A state of the art review section covers fundamentals of wind turbines and PV systems. Included are schematic diagrams illustrating the main components and system topologies and the fundamental and increasing role of power electronics as an enabler for renewable energy integration, and for the future power system and smart grid. Recent examples of research and development, including new devices and system installations for utility power plants, as well for as residential and commercial applications are provided. Fuel cells, solar thermal, wave generators, and energy storage systems are also briefly presented and illustrated. Challenges and future trends for 2025 are summarized in a table for on-shore and off-shore wind energy, solar power, including photovoltaic and concentering, wave energy, fuel cells, and storage with batteries and hydrogen, respectively. Recommended further readings on topics of electric power engineering for renewable energy are included in a final section. This paper also represents an editorial introduction for two special issues of the Electric Power Component and Systems Journal, 43(8–10) and 43(12), respectively.
Molecularly Controlled Coagulation of Carboxyl-Functionalized Nanoparticles Prepared by Surfactant-Free Miniemulsion Polymerization (2012)

We present the synthesis of molecularly controlled "CO<sub>2</sub>-switchable" polystyrene nanoparticles by surfactant-free miniemulsion polymerization using a carboxyl-functionalized surface-active monomer, which acts as comonomer and stabilizer at the same time. The obtained nanoparticles are about 100 nm in size and show a small size distribution, confirmed by dynamic light scattering (DLS) and electron microscopy. Under ambient conditions, the latex particles form a stable suspension that can be coagulated by bubbling CO<sub>2</sub>. The redispersion of the coagulated particles can be easily achieved by ultrasonication. The reversibility of the coagulation is confirmed after several coagulation/redispersion cycles (CO<sub>2</sub> bubbling and ultrasonification) from DLS and zeta potential measurements.
A Reference-Waveform Oversampling Technique in a Fractional-N ADPLL (2021)

This article presents a low-power fractional- <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${N}$ </tex-math></inline-formula> all-digital phase-locked loop (ADPLL) employing a reference-waveform oversampling (ROS) phase detector (PD) that increases its effective rate four times, thus leading to lower jitter and settling time. The proposed ROS-PD adopts a bottom-plate sampling with a voltage zero-forcing technique, which yields high power efficiency and supports fractional phase compensation in the voltage domain through a programmable DAC. The PD output is then amplified by a low-noise gated amplifier and digitized by a low-power successive approximation register analog-to-digital converter (SAR-ADC). Leveraging the benefits of digital architecture, gain mismatches from the waveform estimator are calibrated by means of an LMS algorithm, consequently lowering fractional spurs. The proposed ADPLL is implemented in TSMC 28-nm LP CMOS. The prototype generates a 2.0–2.3-GHz carrier with an rms jitter of 414 fs while consuming only 1.15 mW. This corresponds to a state-of-the-art ADPLL FoM <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">jitter</sub> of −247 dB in a fractional- <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${N}$ </tex-math></inline-formula> mode. Due to the wide (largely linear) monotonic range and <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$4\times $ </tex-math></inline-formula> oversampling rate from a 48-MHz reference, without any additional circuitry, the proposed ADPLL can settle within <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$3~\mu \text{s}$ </tex-math></inline-formula> in face of a 70-MHz frequency step.
Compressive hyperspectral sensor for LWIR gas detection (2012)

Focal plane arrays with associated electronics and cooling are a substantial portion of the cost, complexity, size, weight, and power requirements of Long-Wave IR (LWIR) imagers. Hyperspectral LWIR imagers add significant data volume burden as they collect a high-resolution spectrum at each pixel. We report here on a LWIR Hyperspectral Sensor that applies Compressive Sensing (CS) in order to achieve benefits in these areas. The sensor applies single-pixel detection technology demonstrated by Rice University. The single-pixel approach uses a Digital Micro-mirror Device (DMD) to reflect and multiplex the light from a random assortment of pixels onto the detector. This is repeated for a number of measurements much less than the total number of scene pixels. We have extended this architecture to hyperspectral LWIR sensing by inserting a Fabry-Perot spectrometer in the optical path. This compressive hyperspectral imager collects all three dimensions on a single detection element, greatly reducing the size, weight and power requirements of the system relative to traditional approaches, while also reducing data volume. The CS architecture also supports innovative adaptive approaches to sensing, as the DMD device allows control over the selection of spatial scene pixels to be multiplexed on the detector. We are applying this advantage to the detection of plume gases, by adaptively locating and concentrating target energy. A key challenge in this system is the diffraction loss produce by the DMD in the LWIR. We report the results of testing DMD operation in the LWIR, as well as system spatial and spectral performance.
Unidimensional modeling of 1-3 composite transducers (1990)

Composite transducers, utilizing the complementary properties of a piezoelectric ceramic and a polymer, often possess acoustic matching and electromechanical efficiency that are superior to conventional isotropic materials. The extent of the performance enhancement is a complex function involving composite design in conjunction with external electrical and mechanical loading conditions. This work uses an established modeling technique, supported by finite element analysis and experimental observation, to predict the mechanical, electrical, and piezoelectric properties of 1-3 composite structures. These parameters are then combined in a modified thickness-drive model to predict the performance of composite probe assemblies under realistic operating conditions. Accurate correlation between simulation and experimental results is demonstrated over an extensive range of ceramic-polymer volume fraction. Significantly, the results suggest that composites that possess relatively high-volume fractions of ceramic are superior to the lower volume fraction devices on which previous work has concentrated.
Feeding the pelican: using archival hard drives for cold storage racks (2016)

Microsoft's Pelican storage rack uses a new class of hard disk drive (HDD), known by vendors as archival class HDD. These HDDs are explicitly designed to store cooler and archival data, differing from existing HDDs by trading performance for cost. Our early Pelican experiences have helped some vendors define the particular characteristics of this class of drive. During the last twelve or so months we have gained considerable data on how these drives perform in Pelicans and in this paper we present data gathered from a test and a production environment. A key design choice for Pelican was to have only a small fraction of the HDDs concurrently spun up making Pelican a harsh environment to operate a HDD. We present data showing how the drives have been used, their power profile, their AFR, and conclude by discussing some issues for the future of these archive HDDs. As flash capacities increase eventually all HDDs will be archive class, so understanding their characteristics is of wide interest.
DWPF Materials Evaluation Summary Report (U) (1996)

To better ensure the reliability of the Defense Waste Processing Facility (DWPF) remote canyon process equipment, a materials evaluation program was performed as part of the overall startup test program. Specific test programs included FA-04 ('Process Vessels Erosion/Corrosion Studies') and FA-05 (melter inspection). At the conclusion of field testing, Test Results Reports were issued to cover the various test phases. While these reports completed the startup test requirements, DWPF-Engineering agreed to compile a more detailed report which would include essentially all of the materials testing programs performed at DWPF. The scope of the materials evaouation programs included selected equipment from the Salt Process Cell (SPC), Chemical Process Cell (CPC), Melt Cell, Canister Decon Cell (CDC), and supporting facilities. The program consisted of performing pre-service baseline inspections (work completed in 1992) and follow-up inspections after completion of the DWPF cold chemical runs. Process equipment inspected included: process vessels, pumps, agitators, coils, jumpers, and melter top head components. Various NDE (non-destructive examination) techniques were used during the inspection program, including: ultrasonic testing (UT), visual (direct or video probe), radiography, penetrant testing (PT), and dimensional analyses. Finally, coupon racks were placed in selected tanks in 1992 for subsequent removal and corrosion evaluation after chemical runs.
Grey-Box Approach for the Prediction of Variable Residence Time Distribution in Continuous Pharmaceutical Manufacturing (2020)

Axial dispersion models are used for the prediction of residence time distribution (RTD) of the flow occurring in various processes. Such models are essential for the understanding of the flow dynamics allowing monitoring, control and material tracing specially in the scope of continuous pharmaceutical manufacturing. However, RTDs are most usually dependent on the process variables (PVs), indicating that a single constant parameter dispersion model would not be capable of capturing this variability. In this contribution a variable parameter axial dispersion model is proposed, where the dependency on the process variables are captured from experimental data using Gaussian Process Regression (GPR) models. The method is illustrated with an example of a Vibrated Fluidized Bed Dryer (VFBD), in which a number of tracer experiments are performed at diferent values of the drying process air flow rate and vibration acceleration. The axial dispersion model parameter values are identifed for each experiment. Manifolds for the axial dispersion model parameters are then constructed by the regression of the GP models on the identifed values. Comparisons between the experiments and model predictions for an example validation case are drawn showing that the proposed model is capable of producing accurate RTD predictions and certainty bounds even for points not explicitly included in regression dataset. Insight about the advantages of the method in model based controller design is given.
The effects of recombinant rat μ‐opioid receptor activation in CHO cells on phospholipase C, [Ca2+]i and adenylyl cyclase (1997)

1. The rat mu-opioid receptor has recently been cloned yet its second messenger coupling remains unclear. The endogenous mu-opioid receptor in SH-SY5Y cells couples to phospholipase C (PLC), increases [Ca2+]i and inhibits adenylyl cyclase (AC). We have examined the effects of mu-opioid agonists on inositol(1,4,5)trisphosphate (Ins(1,4,5)P3), [Ca2+]i and adenosine 3':5'-cyclic monophosphate (cyclic AMP) formation in Chinese hamster ovarian (CHO) cells transfected with the cloned mu-opioid receptor. 2. Opioid receptor binding was assessed with [3H]-diprenorphine ([3H]-DPN) as a radiolabel. Ins(1,4,5)P3 and cyclic AMP were measured by specific radioreceptor assays. [Ca2+]i was measured fluorimetrically with Fura-2. 3. Scatchard analysis of [3H]-DPN binding revealed that the Bmax varied between passages. Fentanyl (10 pM 1 microM) dose-dependently displaced [3H]-DPN, yielding a curve which had a Hill slope of less than unity (0.6 +/- 0.1), and was best fit to a two site model, with pK1 values (% of sites) of 9.97 +/- 0.4 (27 +/- 4.8%) and 7.68 +/- 0.07 (73 +/- 4.8%). In the presence of GppNHp (100 microM) and Na+ (100 mM), the curve was shifted to the right and became steeper (Hill slope = 0.9 +/- 0.1) with a pK1 value of 6.76 +/- 0.04. 4. Fentanyl (0.1 nM-1 microM) had no effect on basal, but dose-dependently inhibited forskolin (1 microM)-stimulated, cyclic AMP formation (pIC50 -7.42 +/- 0.23), in a pertussis toxin (PTX; 100 ng ml-1 for 24 h)-sensitive and naloxone-reversible manner (K1 = 1.7 nM). Morphine (1 microM) and [D-Ala2, MePhe4, gly(ol)5]-enkephalin (DAMGO, 1 microM) also inhibited forskolin (1 microM)-stimulated cyclic AMP formation, whilst [D-Pen2, D-Pen5], enkephalin (DPDPE, 1 microM) did not. 5. Fentanyl (0.1 nM-10 microM) caused a naloxone (1 microM)-reversible, dose-dependent stimulation of Ins(1,4,5)P3 formation, with a pEC50 of 7.95 +/- 0.15 (n-5), PTX (100 ng ml-1 for 24 h) abolished, whilst Ni2 (2.5 mM) inhibited (by 52%), the fentanyl-induced Ins(1,4,5)P3 response. Morphine (1 microM) and DAMGO (1 microM), but not DPDPE (1 microM), also stimulated Ins(1,4,5)P3 formation. Fentanyl (1 microM) also caused an increase in [Ca2+]i (80 +/- 16.4 nM, n-6), reaching a maximum at 26.8 +/- 2.5 s. The increase in [Ca2+]i remained elevated until sampling ended (200 s) and was essentially abolished by the addition of naloxone (1 microM). Pre-incubation with naloxone (1 microM, 3 min) completely abolished fentanyl-induced increases in [Ca2+]i. 6. In conclusion, the cloned mu-opioid receptor when expressed in CHO cells stimulates PLC and inhibits AC, both effects being mediated by a PTX-sensitive G-protein. In addition, the receptor couples to an increase in [Ca2+]i. These findings are consistent with the previously described effector-second messenger coupling of the endogenous mu-opioid receptor.
Interferon-Mediated Protein Kinase Activity in Different Fractions of Mouse L-929 Cells (1984)

The interferon (IFN)-mediated protein kinase activity in extracts from mouse L-929 cells is manifested by the phosphorylation of an endogenous 67 kD molecular weight (mw) protein in the presence of double-stranded (ds) RNA. This protein kinase activity can also be assayed after partial purification on poly(I) X poly(C)-Sepharose under phosphatase-free conditions. By the use of this latter technique, here we investigated the distribution of the protein kinase activity in different cellular compartments. Most of the protein kinase activity is found in the post-ribosomal supernatant (S100) fraction, while a small portion of it is associated with the ribosomal salt wash (RSW: 0.5 M KCl eluate of ribosomal pellet) and nuclear fractions. These results are in contrast to several observations in the literature in which the protein kinase activity is thought to be associated with the ribosomal pellet. This controversy results from the conditions used for assay of the protein kinase activity. In fact, when the kinase is assayed in crude extracts supplemented with dsRNA, very little kinase activity is detectable in the S100 fraction compared to the RSW fraction. The S100 fraction contains a high level of phosphatase(s) activity which interferes with the protein kinase assay and might account for the misinterpretation observed in the literature. Some recent results have implicated a correlation between the dsRNA-dependent protein kinase responsible for the phosphorylation of the 67 kD protein and a polyamine-dependent protein kinase which phosphorylates a similar molecular weight protein, subunit of ornithine decarboxylase (Orn Dcase). Here, we show that Orn Dcase does not bind to poly(I) X poly(C)-Sepharose and polyamines do not substitute the requirement of dsRNA for the phosphorylation of the 67 kD protein.
Sensorless parts orienting with a one-joint manipulator (2002)

This paper explores a sensorless technique for orienting planar parts. We follow an approach described in the ours earlier papers (1995), called one joint over conveyor (1JOC), which can perform planar manipulation using a single controlled joint in combination with a constant-velocity conveyor. Our previous work demonstrated that the IJOC approach can orient and feed planar polygonal parts, given a singulated part in a known initial location. This paper shows that a variation called the sensorless IJOC can orient and feed polygonal parts up to symmetries in the underlying mechanics, without knowing the initial location and without sensors.
High-power Kerr-lens mode-locked thin-disk oscillator in the anomalous and normal dispersion regimes (2013)

A femtosecond thin-disk Yb:YAG oscillator in both the anomalous and the normal dispersion regime is demonstrated. Both regimes are realized with practically the same resonator configuration. The power scaling potential of the anomalous and normal dispersion regimes is analyzed both theoretically and experimentally. The recipe to obtain Kerr-lens mode-locking (KLM) in the thin-disk configuration is presented here and oscillator characteristics as well as start-up difficulties are described. The oscillator stability in terms of output power, beam pointing and sensitivity to back reflections is measured and corresponds to the level of commercial systems. © 2013 Copyright SPIE.