gebhart/patrepeval huggingface dataset:
Generation of Transgenic Mice for Studies of Ocular Development and Disease (2003)

Over the past decade, there has been spectacular growth in our understanding of the molecular genetics of eye development and ocular disease. Although this is primarily caused by developments in recombinant DNA technology, it is also caused in large part by advances in, and the spread of, transgenic mouse technology. Whereas 10 years ago few laboratories had the equipment and skill to generate transgenic mice, now most investigators have access to a transgenic core facility. Transgenic mouse studies have fueled our understanding of ocular development, have delineated regulatory elements involved in gene expression in cells of the eye, and have unraveled pathogenic mechanisms involved in eye disease.
Lateral meningocele syndrome: Vertical transmission and expansion of the phenotype (2005)

Lateral meningoceles were first described by Lehman et al. [(1977); J Pediatr 90: 49-54] in a patient with other skeletal findings and distinctive craniofacial features. Subsequently, six more patients with the so-called lateral meningocele syndrome (LMS) have been reported. We describe the findings in three new cases and expand the phenotype. The existence of an affected mother and daughter supports the hypothesis that LMS is a dominant disorder affecting primarily the connective tissue.
The Third International Genomic Medicine Conference (3rd IGMC, 2015): overall activities and outcome highlights (2016)

The Third International Genomic Medicine Conference (3<sup>rd</sup> IGMC) was organised by the Centre of Excellence in Genomic Medicine Research (CEGMR) at the King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia (KSA). This conference is a continuation of a series of meetings, which began with the first International Genomic Medicine Conference (1<sup>st</sup> IGMC, 2011) followed by the second International Genomic Medicine Conference (2<sup>nd</sup> IGMC, 2013). The 3<sup>rd</sup> IGMC meeting presented as a timely opportunity to bring scientists from across the world to gather, discuss, and exchange recent advances in the field of genomics and genetics in general as well as practical information on using these new technologies in different basic and clinical applications. The meeting undoubtedly inspired young male and female Saudi researchers, who attended the conference in large numbers, as evidenced by the oversubscribed oral and poster presentations. The conference also witnessed the launch of the first content for npj Genomic Medicine, a high quality new journal was established in partnership by CEGMR with Springer Nature and published as part of the Nature Partner Journal series. Here, we present a brief summary report of the 2-day meeting including highlights from the oral presentations, poster presentations, workshops, poster prize-winners and comments from the distinguished scientists.
Interconversion of Monohydride Intermediates in Rh(I)-Catalyzed Asymmetric Hydrogenation of Dimethyl 1-Benzoyloxyethenephosphonate (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTInterconversion of Monohydride Intermediates in Rh(I)-Catalyzed Asymmetric Hydrogenation of Dimethyl 1-BenzoyloxyethenephosphonateIlya D. Gridnev, Natsuka Higashi, and Tsuneo ImamotoView Author Information Department of Chemistry, Faculty of Science Chiba University, Chiba 263-8522, Japan Cite this: J. Am. Chem. Soc. 2001, 123, 19, 4631–4632Publication Date (Web):April 19, 2001Publication History Received31 January 2001Revised7 April 2001Published online19 April 2001Published inissue 1 May 2001https://pubs.acs.org/doi/10.1021/ja015611lhttps://doi.org/10.1021/ja015611lrapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views384Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Anions,Catalytic reactions,Hydrogenation,Nuclear magnetic resonance spectroscopy,Solvates Get e-Alerts
Proteomic Evaluation of the Comorbidity-Inflammation Paradigm in Heart Failure With Preserved Ejection Fraction (2020)

Proteins involved in inflammation form a conserved network in HFpEF across 2 independent cohorts and may mediate the association between comorbidity burden and echocardiographic indicators of worse hemodynamics and right ventricular dysfunction. These findings support the comorbidity-inflammation paradigm in HFpEF.
RNA Viruses of Amblyomma variegatum and Rhipicephalus microplus and Cattle Susceptibility in the French Antilles (2020)

Ticks transmit a wide variety of pathogens including bacteria, parasites and viruses. Over the last decade, numerous novel viruses have been described in arthropods, including ticks, and their characterization has provided new insights into RNA virus diversity and evolution. However, little is known about their ability to infect vertebrates. As very few studies have described the diversity of viruses present in ticks from the Caribbean, we implemented an RNA-sequencing approach on <i>Amblyomma variegatum</i> and <i>Rhipicephalus microplus</i> ticks collected from cattle in Guadeloupe and Martinique. Among the viral communities infecting Caribbean ticks, we selected four viruses belonging to the <i>Chuviridae</i>, <i>Phenuiviridae</i> and <i>Flaviviridae</i> families for further characterization and designing antibody screening tests. While viral prevalence in individual tick samples revealed high infection rates, suggesting a high level of exposure of Caribbean cattle to these viruses, no seropositive animals were detected. These results suggest that the <i>Chuviridae</i>- and <i>Phenuiviridae</i>-related viruses identified in the present study are more likely tick endosymbionts, raising the question of the epidemiological significance of their occurrence in ticks, especially regarding their possible impact on tick biology and vector capacity. The characterization of these viruses might open the door to new ways of preventing and controlling tick-borne diseases.
Frontispiz: Catalytic Enantioselective Synthesis of Allylic Boronates Bearing a Trisubstituted Alkenyl Fluoride and Related Derivatives (2019)

Synthesemethoden In der Zuschrift auf S. 12126 ff. zeigen A. H. Hoveyda, H. Ito et al. die erste katalytische diastereo- und enantioselektive Synthese von Allylboronaten mit Z-trisubstituiertem Alkenylfluorid.
Stereoselective Migration of Sterically Hindered Organoboranes in Cyclic and Acyclic Systems. A Stereoselective Allylic C—H Activation Reaction. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Fine feature retention of magnetic resonance images using intensity inhomogeneity weighted non-local filtering (2015)

Electronic noise in the presence of intensity inhomogeneity severely inhibits the robustness of many traditional filtering algorithms. We propose an adaptive filter that utilises the intensity inhomogeneity bias field often observed in magnetic resonance imaging as a map for directing the magnitude of smoothing. This adaptive filter allows for controlled filtering of images where high signal-to-noise (SNR) regions are smoothed less, while low SNR regions are smoothed more intensely. We validated our method with a phantom and MRIs of the lumbar spine. Results showed that the proposed algorithm improved filtering of noise in the presence of intensity inhomogeneity.
Multiagent technology for fault tolerance and flexible control (2006)

One of the main characteristics of multiagent systems (MAS) is fault tolerance. When an agent is unavailable for some reason, another agent with similar capabilities can theoretically compensate for this loss. The system can be designed not only for this kind of fault tolerance but also for others. Many key aspects of fault tolerance in MAS are described in this correspondence including social knowledge and physical distribution. We present a MAS framework that has been designed for control applications, in which fault tolerance and flexibility are key parts of the system
Multispectral photoacoustic assessment of thyroid cancer nodules in vivo (2020)

Thyroid cancer is one of the most commonly diagnosed cancers in the world. Ultrasonography and fine-needle aspiration biopsy are the typical standard-of-care method for diagnosing thyroid nodules. However, about 20% of fine-needle aspiration biopsies generate undeterminable results, which can lead to overdiagnosis and overtreatment. In this study, we propose photoacoustic imaging as an additional triaging tool for identifying cancerous nodules in vivo. We enrolled and photoacoustically imaged 28 patients (19 malignant and 9 benign) who have thyroid nodules. To perform multispectral analysis, we used a series of 5 different wavelengths (i.e., 700, 756, 796, 866, and 900 nm), which were selected based on the optical absorption property of oxy- and deoxy-hemoglobin. All the raw data were automatically stored for further off-line processing, while the corresponding images were visualized on the clinical ultrasound machine in real-time. By using the multispectral photoacoustic data, we calculated the oxygen saturation values of the nodule areas. The result showed that the oxygen saturation level of malignant nodules was lower than that of benign nodules (p &lt; 0.005), which matched with the well-known property of cancerous nodules. Based on the oxygen saturation value, malignant and benign nodules were differentiable with a sensitivity of 80% and specificity of 89%. The result showed the great potential of multispectral photoacoustic analysis as a novel method to identify malignancy of thyroid nodules in vivo. We also verified the robustness of the result by testing reproducibility and comparing inter-physician interpretation.
High-current transmission line pulse characterization of aluminum and copper interconnects for advanced CMOS semiconductor technologies (1998)

High-current phenomena and electrostatic discharge (ESD) in both aluminum and copper interconnects using transmission line pulse (TLP) testing are reported. Critical current density-to-failure, J/sub crit/, is evaluated as a function of pulse width for both wire and via structures. Experimental results demonstrate that copper-based interconnects have superior ESD robustness compared to aluminum-based interconnects.
Anisotropy of ultrasonic backscatter by blood in shear flow: Monte Carlo simulations (2003)

The relation between the heterogeneous microstructure of biological tissues and their measurable scattering properties is still poorly understood. In particular, physical explanation of blood hyperechogenicity when submitted to low shear forces appears incomplete. To quantify the contribution of erythrocyte aggregation to this phenomenon, Monte Carlo 2D simulations of the red cell spatial pattern are performed. The backscattering coefficient of blood at 5 and 40 MHz is estimated for two orthogonal insonification angles, as a function of effective adhesive energy V/sub agg/ and anisotropy index a. Isotropic aggregation resulted in an enhanced backscatter at 5 MHz (+7 dB) but had a minor effect at 40 MHz. Addition of spatial anisotropy essentially diminished the backscatter at 5 MHz, independently on the angle, whereas at 40 MHz, the perpendicular backscatter largely exceeded the parallel backscatter (+6 dB). This showed that anisotropy present in the spatial microscopic pattern can be detected in the high frequency scattering regime, while low frequency backscatter is more affected by larger geometrical features as the aggregate size.
Drones for supply chain management and logistics: a review and research agenda (2021)

This study examines the potentials and challenges of drones, or unmanned autonomous vehicles (UAVs), in supply chain management (SCM) and logistics. A systematic literature review was performed to capture the dynamics surrounding drones and to provide a timely and comprehensive overview of what has been studied so far and what needs to be investigated in the future. 55 publications were selected and thoroughly analysed. The findings of this study illustrate that the potential strengths of applying drones in SCM and logistics are: (1) support of humanitarian logistics, (2) reduced delivery time, (3) reduced cost, (4) improved flexibility, and (5) increased sustainability. In addition, the challenges posed by drones in SCM and logistics are grouped into technical, organisational, safety-related, and regulatory issues. This study also investigates real-life drone deployments in SCM and logistics and sets forth an agenda for future research.
Alteration of Ventricular Fibrillation by Propranolol and Isoproterenol Detected by Epicardial Mapping with 506 Electrodes (1995)

Quantitative analysis revealed that propranolol and isoproterenol do not have symmetrically opposite effects on ventricular fibrillation. Propranolol decreased the number of activation fronts while isoproterenol increased the amount of tissue excited by each activation front. Thus, drugs that alter ventricular refractoriness or excitability alter ventricular fibrillation.
Production of erythroid-potentiating activity by a human T-lymphoblast cell line (erythroid colonies/lymphokine/burst-promoting activity/T lymphocytes/colony-stimulating factor) (2016)

We derived a human T-lymphoblast cell line (Mo) that constitutively elaborates certain lymphokines. The Mo cells produce a colony-stimulating factor necessary for the growth of human granulocyte-monocyte precursors in vitro as well as an erythroid-potentiating activity (EPA) that enhances the proliferation of human erythroid progenitors in vitro. In the presence of serum, the EPA in Mo-conditioned medium stimu- lated the growth of small and large erythroid colonies almost 2-fold. EPA was also produced in serum-free medium, and, when assayed in serum-free cultures of human erythroid progenitors, it stimulated colony growth about 3-fold. The EPA produced by the Mo cell line did not stimulate normal murine erythroid progenitors (CFU-E) or Friend erythroleukemia cell growth in vitro. EPA was inactivated by protease treatment but was re- markably heat stable, with most of the activity recovered after boiling for 15 min. Preliminary biochemical characterization suggests that EPA is an acidic glycoprotein with molecular weight approximately 45,000. EPA is clearly separable from colony-stimulating factor on the basis of heat stability and gel- filtration chromatography. The present observations provide strong support for the concept that activated T cells produce humoral factors important in the regulation of erythropoiesis. The availability of a cell line producing human EPA should facilitate the characterization of the protein and permit defin- itive studies of its biologic effects.
Generic Abstraction of Access Performance and Resources for Multi-Radio Access Management (2007)

In this paper abstract metrics for the performance and resource situation of an access system are derived Such an abstraction is needed for multi-access systems where different, typically heterogeneous access systems shall be coordinated in an efficient way. There, the abstractions are used to compare and evaluate different access technologies as part of the access selection process and also to compare the link capabilities or link performance with the service requirements. The abstractions are performed by means of a generic link layer (GLL), which thereby hides the technology-specific characteristics from the access selection performed by multi-radio resource management (MRRM). It is also shown how these abstracted metrics can be used in a number of different access selection algorithms.
Internal and External Acidity of Faujasites As Measured by a Solvatochromic Spiropyran (2010)

The adsorption of the photochromic 1,3,3-trimethyl-6′-nitroindoline-2-spiro-2′-benzopyran (SP) on Y-zeolites from dichloromethane solution and the ship in the bottle reaction (SIBOR) of SP have been studied by measuring the UV/vis absorption of the resulting materials to achieve information on polarity of the internal and external surface environments. The acidity and α values (hydrogen bond donating ability) of the faujasites significantly differ whether the probe is located at the external surface or inside the Y-zeolite. Additionally, dicyanobis(1,10-phenanthroline)iron(II) [Fe(phen)2(CN)2] (1) and 4-tert-butyl-2-(dicyanomethylene)-5-[4-(diethylamino)benylidene]-Δ3-thiazoline (2) were used as solvatochromic probes for the external surface. The empirical Kamlet−Taft polarity parameter α (hydrogen bond donating (HBD) ability) and π* (dipolarity/polarizability) have been determined for the faujasites surfaces using the linear solvation energy relationship (LSER).
Polarization gaps and negative group velocity in chiral phononic crystals: Layer multiple scattering method (2008)

We designed chiral phononic crystals and studied their properties by using the layer multiple scattering method. The transmittance curves and the corresponding band structures show that this kind of structure possesses significant polarization gaps. The chiral structures break the symmetry so that the degenerate transverse modes split into a pair of right-hand polarized mode and left-hand polarized mode. The polarization splitting in the low-frequency range is enhanced in systems of large filling ratios. We also demonstrate that chiral structures containing strongly resonant units can induce negative group velocity in elastic waves, and stronger resonance brings a wider band of negative group velocity.
Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis (2020)

Fibrosis, or the accumulation of extracellular matrix, is a common feature of many chronic diseases. To interrogate core molecular pathways underlying fibrosis, we cross-examine human primary cells from various tissues treated with TGF-β, as well as kidney and liver fibrosis models. Transcriptome analyses reveal that genes involved in fatty acid oxidation are significantly perturbed. Furthermore, mitochondrial dysfunction and acylcarnitine accumulation are found in fibrotic tissues. Substantial downregulation of the PGC1α gene is evident in both <i>in vitro</i> and <i>in vivo</i> fibrosis models, suggesting a common node of metabolic signature for tissue fibrosis. In order to identify suppressors of fibrosis, we carry out a compound library phenotypic screen and identify AMPK and PPAR as highly enriched targets. We further show that pharmacological treatment of MK-8722 (AMPK activator) and MK-4074 (ACC inhibitor) reduce fibrosis <i>in vivo</i>. Altogether, our work demonstrate that metabolic defect is integral to TGF-β signaling and fibrosis.
Targeting Apoptotic Pathways in Cancer Cells (2004)

Eupalinolide A induces autophagy via the ROS/ERK signaling pathway in hepatocellular carcinoma cells in vitro and in vivo ,
A 24-Dimensional Modulation Format Achieving 6 dB Asymptotic Power Efficiency (2013)

We propose modulation using the extended Golay code over the 24D hypercube, achieving 6 dB asymptotic power efficiency with 1 b/s/Hz/pol spectral efficiency. Noise tolerance is improved by 3 dB over DP-BPSK at a BER of 10−3.
Deamination of Carbocyclic Adenosine Analogs with Adenosine Deaminase and Its Synthetic Utility (1992)

An efficient, convenient, mild synthesis of the carbocyclic inosines from the carbocyclic adenosines via the use of adenosine deaminase is described.
Optical performance of an aspheric multifocal intraocular lens (1991)

A five zone, centrosymmetric, multifocal intraocular lens has been developed using a design analysis approach which assumes that the optical image strength (intensity) achieved by an optical zone is linearly proportional to its aperture. The advantages of including an aspheric zone are discussed, and the optical performance of this IOL is characterized interferometrically. Optical resolution data have been obtained according to the ANSI procedure, using standard Air Force targets. These experimental data are compared with theoretical models of optical performance of diffraction-limited circular, annular, and compound circular-annular lenses.
Measurements and efficient simulations of bowed bars (2000)

Bowing bar percussion instruments is an increasing part of the repertoire of modern composition and performance. Yet the system has not been studied systematically. In this paper experimental measurements of bars of bar percussion instruments bowed by a double bass bow and by a bowing machine are presented. They examine the relationships between performance parameters and perceptional parameters which are relevant for musical performance. In addition, a new efficient simulation method using a time-domain approach has been developed and the measured results are compared to the simulation. Most measurement results are in good qualitative agreement with the known results of the bowed string. The spectrum of the bowed bar is observed to be harmonic, independent of the harmonicity or inharmonicity of the eigenfrequencies of the bar. Important distinctions from the known results of the bowed string are the weakness or independence of bowing force and velocity on the fundamental frequency and the spectral content of the produced sound. Simulations show qualitative agreement with the measurements.
MEET SPE'S PRESIDENT (2018)

Plastics Engineering is the official publication of the Society of Plastics Engineers (SPE). We provide plastics professionals with a wealth of information about machinery, technological advances, materials innovations, sustainability, and more.
Spatio-temporal fuzzy filtering for coding artifacts reduction (2007)

A 3D fuzzy-filtering scheme is proposed for reduction of compression artifacts such as blocking and ringing noises. The proposed scheme incorporates information from temporally-neighboring frames as well as from spatially-neighboring pixels by accounting for the spatio-temporal relationships in the definitions of spatial-rank orders and spread information for the fuzzy-filter. Extra information from a 3D set of pixels of the surrounding frames helps enhance the clustering characteristic of the fuzzy filter while preserving the frame edges. The proposed scheme also exploits the chroma components from neighboring frames to reconstruct the color of the current frame more faithfully. The experimental results show that both the subjective and the objective qualities of post-processed video are significantly improved.