gebhart/patrepeval huggingface dataset:
Planing avoidance H∞ design for supercavitating vehicles (2019)

For the planing forces generated when the underwater high speed vehicle's aft end pierces the bubble which lead to oscillatory motion, planing avoidance control was designed based on observer and compensation in this paper. The effect of this compensation is related to the performance of the controller, hence we consider controllers designed via the H∞ feedback control. In the paper, the H∞ performance requirement which lead to the weight selection problem is analysed also. Through the design of the weighted matrix, the H∞ controller that satisfies various performance requirements is obtained. Simulation results show that this H∞ state feedback controller with the compensating observer can avoid the planing force generated. This method of H∞ weighting coefficients and the compensation method of the disturbance observer can also be a reference for other system design as well.
Fractal Electrochemical Microsupercapacitors (2017)

Abstract The first successful fabrication of microsupercapacitors (μ‐SCs) using fractal electrode designs is reported. Using sputtered anhydrous RuO 2 thin‐film electrodes as prototypes, μ‐SCs are fabricated using Hilbert, Peano, and Moore fractal designs, and their performance is compared to conventional interdigital electrode structures. Microsupercapacitor performance, including energy density, areal and volumetric capacitances, changes with fractal electrode geometry. Specifically, the μ‐SCs based on the Moore design show a 32% enhancement in energy density compared to conventional interdigital structures, when compared at the same power density and using the same thin‐film RuO 2 electrodes. The energy density of the Moore design is 23.2 mWh cm −3 at a volumetric power density of 769 mW cm −3 . In contrast, the interdigital design shows an energy density of only 17.5 mWh cm −3 at the same power density. We show that active electrode surface area cannot alone explain the increase in capacitance and energy density. We propose that the increase in electrical lines of force, due to edging effects in the fractal electrodes, also contribute to the higher capacitance. This study shows that electrode fractal design is a viable strategy for improving the performance of integrated μ‐SCs that use thin‐film electrodes at no extra processing or fabrication cost.
Effects of Helical Distortions on the Optical Properties of Amide NH Infrared Absorption in Short Peptides in Solution (2002)

The secondary structure of ordered peptides in solution usually exhibits helical distortions that are enhanced by the shortness of the backbone chain. These distortions are reflected in the optical properties of amide NH infrared absorption and in the shape of the CD spectra. These effects are exemplified here in a series of short, intramolecularly H-bonded peptides of the general formula F[(αMe)Val]r-T-[(αMe)Val]2NHt-Bu where T = Toac and F = Fmoc, a nitroxide-based α-amino acid quencher and a fluorophoric Nα protecting group, respectively, where r = 0−3. Their structural features in methanol were determined by a combined approach of time-resolved fluorescence resonance energy transfer measurements and molecular mechanics calculations. They show a rather compact arrangement of the probes around the distorted, 310-helical backbone chain, which accounts for the slow interconversion between conformational substates on the nanosecond time scale.
A novel CXCR4 antagonist IgG1 antibody (PF-06747143) for the treatment of hematologic malignancies (2017)

The chemokine receptor CXCR4 is highly expressed and associated with poor prognosis in multiple malignancies. Upon engagement by its ligand, CXCL12, CXCR4 triggers intracellular signaling pathways that control trafficking of cells to tissues where the ligand is expressed, such as the bone marrow (BM). In hematologic cancers, CXCR4-driven homing of malignant cells to the BM protective niche is a key mechanism driving disease and therapy resistance. We developed a humanized CXCR4 immunoglobulin G1 (IgG1) antibody (Ab), PF-06747143, which binds to CXCR4 and inhibits CXCL12-mediated signaling pathways, as well as cell migration. In in vivo preclinical studies, PF-06747143 monotherapy rapidly and transiently mobilized cells from the BM into the peripheral blood. In addition, PF-06747143 effectively induced tumor cell death via its Fc constant region-mediated effector function. This Fc-mediated cell killing mechanism not only enhanced antitumor efficacy, but also played a role in reducing the duration of cell mobilization, when compared with an IgG4 version of the Ab, which does not have Fc-effector function. PF-06747143 treatment showed strong antitumor effect in multiple hematologic tumor models including non-Hodgkin lymphoma (NHL), acute myeloid leukemia (AML), and multiple myeloma (MM). Importantly, PF-06747143 synergized with standard-of-care agents in a chemoresistant AML patient-derived xenograft model and in an MM model. These findings suggest that PF-06747143 is a potential best-in-class anti-CXCR4 antagonist for the treatment of hematologic malignancies, including in the resistant setting. PF-06747143 is currently in phase 1 clinical trial evaluation (registered at www.clinicaltrials.gov as #NCT02954653).
SDOCT Doppler velocimetry for investigating the morphological influences on blood flow in the developing chick embryo heart (2007)

The onset of congenital heart disease (CHD) is believed to occur at very early stages of development. Investigations in the initiation and development of CHD has been hampered by the inability to image early stage heart structure and function, <i>in vivo</i>. Imaging small animals using optical coherence tomography (OCT) has filled a niche between the limited penetration depth of confocal microscopy and insufficient resolution from ultrasound. Previous demonstrations of chick heart imaging using OCT have entailed excision of, or arresting the heart to prevent motion artifacts. In this summary, we introduce SDOCT Doppler velocimetry as an enhancement of Doppler OCT for <i>in vivo </i>measurement of localized temporal blood flow dynamics. With this technique, dynamic velocity waveforms were measured in the outflow tract of the heart tube. These flow dynamics correlate to a finite element model of pulsatile flow and may lead to a further understanding of morphological influences on early heart development.
Geometria sintética: narrativa de um episódio com uma aluna-professora (2017)

O artigo aborda um episodio de uma aula de Geometria num mestrado profissional em Ensino de Matematica, vivenciado pelo autor, Brasil. Trata de pesquisa qualitativa com caracteristicas indutiva, explicativa e descritiva. A questao foi verificar como o dialogo/intermediacao do professor, na realizacao de uma situacao-problema, pode proporcionar demonstracao sintetica de uma proposicao matematica? O objetivo foi descrever e analisar o episodio de sala de aula entre professor e estudante na resolucao da questao de pesquisa. O metodo foi o da Geometria Sintetica e os dados, os dialogos entre os dois. Conclui-se que o objetivo foi alcancado, pois a estudante obteve a solucao e o enunciado de uma das proposicoes que conduziram ao problema de Apolonio .
Nitration studies. XVIII. Conversion of lower nitroalkanes to higher members of the series (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNitration studies. XVIII. Conversion of lower nitroalkanes to higher members of the seriesG. Bryant Bachman and Robert J. MaleskiCite this: J. Org. Chem. 1972, 37, 18, 2810–2814Publication Date (Print):September 1, 1972Publication History Published online1 May 2002Published inissue 1 September 1972https://pubs.acs.org/doi/10.1021/jo00983a003https://doi.org/10.1021/jo00983a003research-articleACS PublicationsRequest reuse permissionsArticle Views357Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
836 Is normalization of blood pressure safe and beneficial in elderly hypertensive patients? (2012)

Objectives: The VALISH (Valsartan in Elderly Isolated Systolic Hypertension) study showed that strict control of systolic blood pressure (BP) of < 140 mmHg are safely achievable in relatively healthy patients aged 70-84 years with isolated systolic hypertension and that strict control was not superior to moderate blood pressure control (140-150 mmHg) in reducing cardiovascular mortality and morbidity although the trial was underpowered (1). This subanalysis of the VALISH study was done to investigate whether more stringent control of BP to the normal level is safe and beneficial for cardiovascular prognosis. Methods: We divided 3079 patients into 4 groups according to the achieved systolic BP; G1: <130 (n = 499), G2: 130-139 (n = 1070), G3: 140-149 (n = 1027), and G4: ≥150 mmHg (n = 483). We compared the primary endpoint of the main study. Results: BP at the baseline was not significantly different among 4 groups. Average of achieved BP was 121/68, 134/75, 143/78, 161/80 mmHg in G1, G2, G3 and G4, respectively. Age- and sex- adjusted hazard ratio of primary endpoint in each group compared with G3 was 1.07 (95%CI 0.56-1.95, P = 0.84), 0.88 (95%CI 0.51-1.50, P = 0.64) and 2.09 (95%CI 1.24-3.55, P = 0.006) in G1, G2 and G4, respectively. J-shape phenomenon was not investigated even in patients whose BP achieved less than 120 mmHg. Conclusion: The VALISH subanalysis revealed that normalization of BP in the elderly is probably safe but its benefit in the reduction of cardiovascular events is so small and that reduction of BP less than 150 mmHg is significantly important. (1) Hypertension. 2010; 56: 196-202
Methyl Diazoacetate (2001)

[6832-16-2] C3H4N2O2 (MW 100.09) (cyclopropanation of alkenes;2, 3 cyclopropenation of alkynes;4 addition to aromatic substrates;5, 6 insertion into polar XH bonds;7 condensation with carbonyls;8 1,3-dipolar cycloaddition with enamines9 and alkynes,10 yielding substituted pyrazolines and pyrazoles) Physical Data: bp 39–43 °C/10 mmHg. Solubility: sol diethyl ether, dichloromethane, chloroform, benzene. Preparative Method: from methyl glycinate hydrochloride and sodium nitrite upon treatment with a 5% solution of sulfuric acid.11 Handling, Storage, and Precautions: extreme caution should be exercised in handling methyl diazoacetate since it is thermally unstable and has been found to detonate if heated rapidly or overheated (do not expose to temperatures >50 °C), emitting toxic fumes of NOx. Diazo esters are also toxic and should be handled in a well-ventilated fume hood.
3D printed conformal array antenna: Simulations and measurements (2016)

A conformal array antenna has been investigated using a combination of 3D printer and copper plating techniques. Circular patch antenna elements were copper plated onto a 3D printed dielectric substrate made of ABS-M30 material. Measured and simulated element reflection coefficient, element gain patterns, and array scanned beam radiation patterns at L band are in good agreement.
Pulse-field-assisted bonding for SOI devices (1988)

A technique for obtaining bulk-quality silicon layers on silicon dioxide by pulse-field assisted bonding of oxidized silicon wafers has been developed. Radiation-hardened 64 K silicon-on-insulator (SOI) DRAMs (dynamic random-access memories) were fabricated for the first time to the authors' knowledge by a conventional bulk DRAM process. Void-free bonding is done by pressing the oxidized surfaces of two wafers together and applying an impulsive electrostatic force. The oxide thickness ranges from 0.05 to 4.0 mu m. The pair of wafers is then placed on a SiC-coated carbon strip heater and heated to 800 degrees C in a 0.1-Pa nitrogen atmosphere. A silicon strip electrode is placed on one wafer to make an electrical contact with the other. A bonding-pulse amplitude of 100 to 500 V is applied between the electrode and the lower heater. Voids are eliminated when the pulse is applied. Bonded wafers are then annealed and thinned by polishing and/or chemical etching to the desired thickness. The characteristics of the MOSFETs and DRAMs obtained by this method are briefly described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Nonclinical Development of Next-generation Site-specific HER2-targeting Antibody–drug Conjugate (ARX788) for Breast Cancer Treatment (2020)

Conventional antibody-drug conjugates (ADC) utilize native surface-exposed lysines or cysteines on the antibody of interest to conjugate cytotoxic payload. The nonspecific conjugation results in a mixture with variable drug-to-antibody ratios (DAR), conjugation sites, and ADCs that are often unstable in systemic circulation. ARX788 is an ADC consisting of a HER2-targeting antibody site-specifically conjugated with a potent antitubulin cytotoxic drug-linker, AS269. The site-specific conjugation is achieved by first incorporating the nonnatural amino acid, <i>para</i>-acetyl phenylalanine (pAF), into the antibody, followed by covalent conjugation of AS269 to the pAF to form a highly stable oxime bond resulting in a DAR 2 ADC. ARX788 exhibits significant, dose-dependent antitumor activity against HER2- expressing breast and gastric xenograft tumors. Pharmacokinetic (PK) studies in multiple species showed the highly stable nature of ARX788 with overlapping PK profiles for the intact ADC and total antibody. Metabolism studies demonstrated that pAF-AS269 was the sole major metabolite of ARX788, with no evidence for the release of free drug often observed in conventional ADCs and responsible for adverse side effects. Furthermore, ARX788 demonstrated a favorable safety profile in monkeys with a highest nonseverely toxic dose of 10 mg/kg, which was well above the efficacious dose level observed in preclinical tumor models, thus supporting clinical development of ARX788.
Interaction of hydrogen with TaC(111) and NbC(111) surfaces: Angle-resolved photoemission study (1995)

Angle-resolved photoemission spectroscopy utilizing synchrotron radiation has been used to study the interaction of hydrogen with TaC(111) and NbC(111) surfaces. The electronic structures of the TaC(111) and NbC(111) clean surfaces are characterized by the surface-induced state at just below the Fermi level. Hydrogen adsorption induces the shift of the state to the higher-binding-energy side by \ensuremath{\sim}0.5 eV at the \ensuremath{\Gamma}\ifmmode\bar\else\textasciimacron\fi{} point for both surfaces. However, no H 1s--induced split-off state is found in the photoemission spectra for both surfaces. This invisible state is proposed to be an adsorption in a subsurface site. The electronic structures of the H-adsorbed TaC(111) and NbC(111) surfaces are investigated by off-normal-emission measurements, and it is found that the surface electronic structures are similar to those of the original clean surfaces; the two-dimensional band structures of the H-modified surface states are similar to those for the intrinsic surface states on both surfaces. A possible hydrogen adsorption site in the subsurface region is also proposed.
Transparent Electrodes: ZnO/Polyfluorene Hybrid LED on an Efficient Hole‐Transport Layer of Graphene Oxide and Transparent Graphene Electrode (Advanced Optical Materials 4/2014) (2014)

An rGO/GO/PFO/ZnO/Al LED is fabricated via simple solution-based techniques by K. ul Hasan Hasan et al. On page 326, they show how graphene can be a simple solution-processable substitute to PEDOT:PSS as an effective holetransport (electron-blocking) layer, and ITO as a transparent conductive electrode in optoelectronic devices. The wide emission range of this LED opens up prospects for demonstrating white light-emitting devices from this novel combination. This could pave the way for cheaper displays.
A Novel Progress Variable Approach for Predicting NO in Laminar Hydrogen Flames (2010)

Due to the enforcement of strict regulations on NO emissions in technical applications, the inclusion of pollutant prediction into computational fluid dynamics (CFD) is becoming more and more important in everyday engineering. In order to capture all pathways of NO formation accurately the use of detailed chemistry in CFD is mandatory. Solving a transport equation for all species of a detailed reaction mechanism however is too costly for engineering purposes. Therefore an approach is discussed in the present paper which is based on the solution of a transport equation for NO where the chemical source term is retrieved as a function of reaction progress and mixture fraction from look-up tables. These look-up tables are computed by simulating an ensemble of laminar premixed flames at dierent mixture fractions using detailed chemistry. In order to define reaction progress for a given mixture fraction, the length of the H2O-NO-trajectory is used. A transport equation for the reaction progress is then derived. This tabulation concept is validated by computing dierent laminar, counterflow, hydrogen-air diusion flames with a finite volume solver. Comparisons with experimental data (NO and temperature profiles) and with finite rate chemistry simulations prove that the new model is capable to predict NO accurately.
<title>Mining temporal data sets: hypoplastic left heart syndrome case study</title> (2003)

Hypoplastic left heart syndrome (HLHS) affects infants and is uniformly fatal without surgery. Post-surgery mortality rates are highly variable and dependent on postoperative management. The high mortality after the first stage surgery usually occurs within the first few days after procedure. Typically, the deaths are attributed to the unstable balance between the pulmonary and systemic circulations. An experienced team of physicians, nurses, and therapists is required to successfully manage the infant. However, even the most experienced teams report significant mortality due to the extremely complex relationships among physiologic parameters in a given patient. A data acquisition system was developed for the simultaneous collection of 73 physiologic, laboratory, and nurse-assessed variables. Data records were created at intervals of 30 seconds. An expert-validated wellness score was computed for each data record. A training data set consisting of over 5000 data records from multiple patients was collected. Preliminary results demonstratd that the knowledge discovery approach was over 94.57% accurate in predicting the "wellness score" of an infant. The discovered knowledge can improve care of complex patients by development of an intelligent simulator that can be used to support decisions.
Pharmacokinetic and pharmacodynamic properties of the novel basal insulin Fc (insulin efsitora alfa), an insulin fusion protein in development for once‐weekly dosing for the treatment of patients with diabetes (2022)

BIF was well tolerated and the PK/PD profile enabled once-weekly dosing with minimal variation in exposure in a treatment interval of 1 week. The findings suggest BIF is suitable for further development as a weekly basal insulin in people with diabetes.
Cationic Modifications of Polychloroprene. IV. Synthesis and Characterization of Poly(chloroprene-g-isobutylene) Carrying tert-Chloride Branch Termini (1982)

Abstract This paper concerns the preparation and characterization of a new graft copolymer comprising polychloroprene backbone and polyisobutylene branches which carry tertiary chlorine termini. Synthesis involved the grafting of isobutylene from polychloroprene by the use of BCI3 coinitiator in methylene chloride solvent in the -12 to -78°C range. Conditions have been defined for efficient and convenient graft copolymerizations. Carefully purified grafts (selective solvent extraction) were characterized by a battery of analytical techniques including 1H-NMR spectroscopy and GPC. Agreement between calculated and experimental graft M n's indicate absence of disturbing side reactions, i.e., backbone degradation and cross-linking, during synthesis. The presence of tertiary chlorine endgroups has been demonstrated by thermal dehydrochlorination studies. Branch molecular weight, molecular weight distribution, and frequency have been obtained by selective oxidative destruction of the polychloroprene backbone followed by surviving branch analysis. A graft prepared at -20°Carried ∼5 polyisobutylene branches of M n = 5000 each.
Bacillus subtilis mutants with alterations in ribosomal protein S4 (1990)

Two mutants with different alterations in the electrophoretic mobility of ribosomal protein S4 were isolated as spore-plus revertants of a streptomycin-resistant, spore-minus strain of Bacillus subtilis. The mutations causing the S4 alterations, designated rpsD1 and rpsD2, were located between the argGH and aroG genes, at 263 degrees on the B. subtilis chromosome, distant from the major ribosomal protein gene cluster at 12 degrees. The mutant rpsD alleles were isolated by hybridization using a wild-type rpsD probe, and their DNA sequences were determined. The two mutants contained alterations at the same position within the S4-coding sequence, in a region containing a 12-bp tandem duplication; the rpsD1 allele corresponded to an additional copy of this repeated segment, resulting in the insertion of four amino acids, whereas the rpsD2 allele corresponded to deletion of one copy of this segment, resulting in the loss of four amino acids. The effects of these mutations, alone and in combination with streptomycin resistance mutations, on growth, sporulation, and streptomycin resistance were analyzed.
Proto-oncogene expression in cloned T lymphocytes: mitogens and growth factors induce different patterns of expression. (1987)

We have compared the effects of a mitogenic lectin, concanavalin A (Con A), and a growth factor, interleukin-2 (IL-2), on the expression of the c-myc, c-fos, and c-myb proto-oncogenes in cloned T lymphocytes. Accumulation of c-myc mRNA was induced by both ConA and IL-2 in these cells. In contrast, expression of c-fos was stimulated primarily by ConA, and accumulation of c-myb mRNA was induced predominantly by IL-2. Thus, ConA and IL-2 induce expression of overlapping, but non-identical, sets of proto-oncogenes in T lymphocytes. Investigations with several different cloned T cells revealed that: (1) c-myb is not induced in all T cells stimulated to grow, indicating that its expression may not be absolutely required for their proliferation; and (2) expression of c-myc, even in combination with c-fos, can be insufficient for growth, demonstrating functional differences between cellular and viral oncogenes in T cells. These observations provide insight into the roles of the c-myc, c-fos, and c-myb proto-oncogenes in normal T cell responses.