gebhart/patrepeval huggingface dataset:
Crystal structure of hexa-μ-chlorido-μ4-oxido-tetrakis{[1-(2-hydroxyethyl)-2-methyl-5-nitro-1H-imidazole-κN 3]copper(II)} containing short NO2...NO2 contacts (2019)

The title tetra-nuclear copper complex, [Cu<sub>4</sub>Cl<sub>6</sub>O(C<sub>6</sub>H<sub>9</sub>N<sub>3</sub>O<sub>3</sub>)<sub>4</sub>] or [Cu<sub>4</sub>Cl<sub>6</sub>O-(MET)<sub>4</sub>] [MET is 1-(2-hy-droxy-eth-yl)-2-methyl-5-nitro-1<i>H</i>-imidazole or metronidazole], contains a tetra-hedral arrangement of copper(II) ions. Each copper atom is also linked to the other three copper atoms in the tetra-hedron <i>via</i> bridging chloride ions. A fifth coordination position on each metal atom is occupied by a nitro-gen atom of the monodentate MET ligand. The result is a distorted CuCl<sub>3</sub>NO trigonal-bipyramidal coordination polyhedron with the axial positions occupied by oxygen and nitro-gen atoms. The extended structure displays O-H⋯O hydrogen bonding, as well as unusual short O⋯N inter-actions [2.775 (4) Å] between the nitro groups of adjacent clusters that are oriented perpendicular to each other. The scattering contribution of disordered water and methanol solvent mol-ecules was removed using the SQUEEZE procedure [Spek (2015 ▸). <i>Acta Cryst</i>. C<b>71</b>, 9-16] in <i>PLATON</i> [Spek (2009 ▸). <i>Acta Cryst.</i> D<b>65</b>, 148-155].
Mechanism of inactivation of .gamma.-aminobutyric acid-.alpha.-ketoglutaric acid aminotransferase by 4-amino-5-halopentanoic acids (1981)

(S)-4-Amino-5-halopentanoic acids were previously shown to irreversibly inhibit pig brain gamma-aminobutyric acid--alpha-ketoglutaric acid aminotransferase, and a mechanism for the inactivation was proposed (Silverman, R. B., & Levy M. A. (1980) Biochem. Biophys. Res. Commun. 95, 250). Evidence is presented to show that these compounds are mechanism-based inactivators, and experiments are described to elucidate their mechanism of action. The enzyme must be in the pyridoxal phosphate form for inactivation to occur, the gamma proton of the inactivators is removed in a rate-determining step, and one fluoride ion is released from 4-amino-5-fluoropentanoic acid per active site labeled. The change in the optical spectrum of the enzyme during inactivation suggests that the coenzyme is converted into the pyridoxamine phosphate form. Every turnover of inactivator leads to an inactivation event, i.e., the partition ratio is zero.
Synthesis and structure-activity relationships of pyridoxal-6-arylazo-5?-phosphate and phosphonate derivatives as P2 receptor antagonists (2020)

Novel analogs of the P2 receptor antagonist pyridoxal-5′-phosphate-6-phenylazo-2′,4′-disulfonate (PPADS) were synthesized. Modifications were made through functional group substitution on the sulfophenyl ring and at the phosphate moiety through the inclusion of phosphonates, demonstrating that a phosphate linkage is not required for P2 receptor antagonism. Substituted 6-phenylazo and 6-naphthylazo derivatives were also evaluated. Among the 6-phenylazo derivatives, 5′-methyl, ethyl, propyl, vinyl, and allyl phosphonates were included. The compounds were tested as antagonists at turkey erythrocyte and guinea-pig taenia coli P2Y1 receptors, in guinea-pig vas deferens and bladder P2X1 receptors, and in ion flux experiments by using recombinant rat P2X2 receptors expressed in Xenopus oocytes. Competitive binding assay at human P2X1 receptors in differentiated HL-60 cell membranes was carried out by using [35S]ATP-γ-S. A 2′-chloro-5′-sulfo analog of PPADS (C14H12O9N3ClPSNa), a vinyl phosphonate derivative (C15H12O11N3PS2Na3), and a naphthylazo derivative (C18H14O12N3PS2Na2), were particularly potent in binding to human P2X1 receptors. The potencies of phosphate derivatives at P2Y1 receptors were generally similar to PPADS itself, except for the p-carboxyphenylazo phosphate derivative C15H13O8N3PNa and its m-chloro analog C15H12O8N3ClPNa, which were selective for P2X vs. P2Y1 receptors. C15H12O8N3ClPNa was very potent at rat P2X2 receptors with an IC50 value of 0.82 μM. Among the phosphonate derivatives, [4-formyl-3-hydroxy-2-methyl-6-(2-chloro-5-sulfonylphenylazo)-pyrid-5-yl]methylphosphonic acid (C14H12-O8N3ClPSNa) showed high potency at P2Y1 receptors with an IC50 of 7.23 μM. The corresponding 2,5-disulfonylphenyl derivative was nearly inactive at turkey erythrocyte P2Y1 receptors, whereas at recombinant P2X2 receptors had an IC50 value of 1.1 μM. An ethyl phosphonate derivative (C15H15O11N3PS2Na3), whereas inactive at turkey erythrocyte P2Y1 receptors, was particularly potent at recombinant P2X2 receptors.
Matrix design for optimal sensing (2013)

We design optimal 2 × N (2 <; N) matrices, with unit columns, so that the maximum condition number of all the submatrices comprising 3 columns is minimized. The problem has two applications. When estimating a 2-dimensional signal by using only three of N observations at a given time, this minimizes the worst-case achievable estimation error. It also captures the problem of optimum sensor placement for monitoring a source located in a plane, when only a minimum number of required sensors are active at any given time. For arbitrary N ≥ 3, we derive the optimal matrices which minimize the maximum condition number of all the submatrices of three columns. Surprisingly, a uniform distribution of the columns is not the optimal design for odd N ≥ 7.
CD83 Gene Polymorphisms Increase Susceptibility to Human Invasive Cervical Cancer (2007)

We previously mapped a nonrandom frequent loss of heterozygosity (LOH) region in cervical cancers to 1 Mb of 6p23. Here, we describe the identification of a novel cervical cancer susceptibility gene, CD83. The gene was identified by several complementary approaches, including a family-based association study, comparison of transcript expression in normal and cancerous tissue, and genomic sequencing of candidate. CD83 encodes an inducible glycoprotein in the immunoglobulin superfamily and is a marker for mature dendritic cells. The association study that includes 377 family trios showed that five single nucleotide polymorphisms (SNP) within 8 kb of its 3'-end showed significant allelic association that was strengthened in a subgroup of women with invasive cancers infected by high-risk human papillomavirus type 16 and 18 (rs9296925, P = 0.0193; rs853360, P = 0.0035; rs9230, P = 0.0011; rs9370729, P = 0.0012; rs750749, P = 0.0133). Investigation of CD83 uncovered three alternative transcripts in cervical tissue and cell lines, with variant 3 (lacking exons 3 and 4) being more frequent in cervical cancer than in normal cervical epithelium (P = 0.0181). Genomic sequencing on 36 paired normal and cervical tumors revealed several somatic mutations and novel SNPs in the promoter, exons, and introns of CD83. LOH was confirmed in >90% of cervical cancer specimens. Immunofluorescence colocalized CD83 protein to the Golgi apparatus and cell membrane of cervical cancer cell lines. None of seven nearby genes was differentially expressed in cervical cancer. The importance of CD83 in epithelial versus dendritic cells needs to be determined, as does its role in promoting cervical cancer.
Fiber Optic Projection-Imaging System for Shape Measurement in Confined Space (2014)

A fiber-based projection-imaging system is proposed for shape measurement in confined space. Owing to the flexibility of imaging fibers, the system can be used in special scenarios that are difficult for conventional experimental setups. Three experiments: open space, closed space, and underwater are designed to demonstrate the strength and weakness of the system. It is shown that when proper alignment is possible, relatively high accuracy can be achieved; the error is less than 2% of the overall height of a specimen. In situations where alignment is difficult, significantly increased error is observed. The error is in the form of gross-scale geometrical distortion; for example, flat surface is reconstructed with curvature. In addition, the imaging fibers may introduce fine-scale noise into phase measurement, which has to be suppressed by smoothing filters. Based on results and analysis, it is found that although a fiber-based system has its unique strength, existing calibration and processing methods for fringe patterns have to be modified to overcome its drawbacks so as to accommodate wider applications.
6-Formylindolo(3,2-b)carbazole Dampens Inflammation and Reduces Endotoxin-Induced Kidney Injury via Nrf2 Activation (2023)

Patients with sepsis are at a high risk of morbidity and mortality due to multiple organ injuries caused by pathological inflammation. Although sepsis is accompanied by multiple organ injuries, acute renal injury is a significant contributor to sepsis morbidity and mortality. Thus, dampening inflammation-induced renal injury may limit severe consequences of sepsis. As several studies have suggested that 6-formylindolo(3,2-b)carbazole (FICZ) is beneficial for treating various inflammatory diseases, we aimed to examine the potential protective effect of FICZ on the acute endotoxin-induced sepsis model of kidney injury. To test this, male C57Bl/6N mice were injected with FICZ (0.2 mg/kg) or vehicle 1 h prior to an injection of either lipopolysaccharides (LPS) (10 mg/kg), to induce sepsis, or phosphate-buffered saline for 24 h. Thereafter, gene expression of kidney injury and pro-inflammatory markers, circulating cytokines and chemokines, and kidney morphology were assessed. Our results show that FICZ reduced LPS-induced acute injury in kidneys from LPS-injected mice. Furthermore, we found that FICZ dampens both renal and systemic inflammation in our sepsis model. Mechanistically, our data indicated that FICZ significantly upregulates NAD(<i>P</i>)H quinone oxidoreductase 1 and heme oxygenase 1 via aryl hydrocarbon receptor (AhR) and nuclear factor erythroid 2-related factor 2 (Nrf2) in the kidneys to lessen inflammation and improve septic acute kidney injury. Overall, the data of our study show that FICZ possesses a beneficial reno-protective effect against sepsis-induced renal injury via dual activation of AhR/Nrf2.
Lot acceptance sampling inspection plan for non-normal CD distribution (2008)

The optimizing of sampling plans for process control and lot acceptance inspections is emerging as an important subject concerning the recent lithography process. With proper acceptance variables, one can reduce sample size using inspection by variables rather than inspection by attributes. The inspection by variables is cost-effective and desirable. However, it is difficult to apply to a non-normal population. Many cases exist where CD distribution cannot be regarded as normal. If one applies the acceptance sampling inspection with conventional acceptance variables@in those cases, the inspections become tighter or are reduced, which is contrary to expectations. The problem of non-normality, which is an essential property of CD distributions, should be treated extensively. We found that the above problem can be overcome by modifying the conventional acceptance variables through the inclusion of the 3rd moment. As a result, 50% reduction of sample size can be realized by introducing the lot acceptance sampling with new variables.
Adenosine and the Auditory System (2009)

Adenosine is a signalling molecule that modulates cellular activity in the central nervous system and peripheral organs via four G protein-coupled receptors designated A(1), A(2A), A(2B), and A(3). This review surveys the literature on the role of adenosine in auditory function, particularly cochlear function and its protection from oxidative stress. The specific tissue distribution of adenosine receptors in the mammalian cochlea implicates adenosine signalling in sensory transduction and auditory neurotransmission although functional studies have demonstrated that adenosine stimulates cochlear blood flow, but does not alter the resting and sound-evoked auditory potentials. An interest in a potential otoprotective role for adenosine has recently evolved, fuelled by the capacity of A(1) adenosine receptors to prevent cochlear injury caused by acoustic trauma and ototoxic drugs. The balance between A(1) and A(2A) receptors is conceived as critical for cochlear response to oxidative stress, which is an underlying mechanism of the most common inner ear pathologies (e.g. noise-induced and age-related hearing loss, drug ototoxicity). Enzymes involved in adenosine metabolism, adenosine kinase and adenosine deaminase, are also emerging as attractive targets for controlling oxidative stress in the cochlea. Other possible targets include ectonucleotidases that generate adenosine from extracellular ATP, and nucleoside transporters, which regulate adenosine concentrations on both sides of the plasma membrane. Developments of selective adenosine receptor agonists and antagonists that can cross the blood-cochlea barrier are bolstering efforts to develop therapeutic interventions aimed at ameliorating cochlear injury. Manipulations of the adenosine signalling system thus hold significant promise in the therapeutic management of oxidative stress in the cochlea.
Quad-interleaved Block Level Parallel Direct Binary Search Algorithm (2016)

Direct Binary Search (DBS), as one of the three categories of halftoning, provides the best, visually pleasing halftoning quality. However, as a sequential algorithm, DBS is most computational complex so it always plays the role of offline algorithm for other halftoning categories (like tone dependent error diffusion, hybrid screen, etc.). Meanwhile, it is seldom directly works as a real-time/online solution for current commercial printers. In this paper, we would like to present a parallel version DBS with same image quality compared with original DBS, which can fit the current Same Instruction Multiple Data (SIMD) system, like General-Purpose Graphics Processing Unit (GP-GPU), and furthermore, there will be the potential that DBS can work on current multi-core system as real-time solution for halftoning.
Effect of Phase on the Electrochemical and Morphological Properties of Praseodymium-Based Coatings (2011)

The corrosion protection of epoxy-polyamide primers containing either hexagonal Pr2O3 or cubic Pr6O11 inhibitors deposited on chromate conversion coated Al 2024-T3 substrates was studied. Electrochemical evaluations, scanning electron microscopy with energy dispersive spectroscopy, and x-ray diffraction were used to characterize primers. The electrochemical response of coated panels prior to and following ASTM B117 salt spray exposure was also studied. The addition of PrOx species to the primer matrix improved the corrosion protection of artificial defects by decreasing icorr values from ~10-7 to ~10-9 A/cm2, increasing the passivation range (&gt; 300 mV), and shifting Ecorr values to more negative potentials. After salt spray testing, Pr-hydroxide/hydroxycarbonate species were present on the surfaces of the primers. The addition of Pr2O3 afforded enhanced corrosion protection compared to the addition of Pr6O11 because Pr2O3 is a more reactive phase that provided more Pr3+ species for transport and reaction than Pr6O11.
Subspace techniques for large-scale feature selection (1993)

A novel feature selection algorithm is presented which outperforms the well-known SFS (sequential forward selection) and SBS (sequential backward selection) algorithms for large-scale problems. The approach utilizes the solution to the similar problem of large-scale feature extraction by choosing a subset of the original measurements that are closest to the space spanned by the extracted (transformed) features. The authors develop a computationally efficient Frobenius subspace distance metric for the subspace comparisons, which reduces the complexity from order N taken k at a time to order N/sup 3/ operations. Finally, sufficient conditions for optimality of the algorithm are presented that demonstrate the relationship between the feature extraction and the feature selection solutions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Sparse Conjoint Analysis Through Maximum Likelihood Estimation (2013)

Conjoint analysis (CA) is a classical tool used in preference assessment, where the objective is to estimate the utility function of an individual, or a group of individuals, based on expressed preference data. An example is choice-based CA for consumer profiling, i.e., unveiling consumer utility functions based solely on choices between products. A statistical model for choice-based CA is investigated in this paper. Unlike recent classification-based approaches, a sparsity-aware Gaussian maximum likelihood (ML) formulation is proposed to estimate the model parameters. Drawing from related robust parsimonious modeling approaches, the model uses sparsity constraints to account for outliers and to detect the salient features that influence decisions. Contributions include conditions for statistical identifiability, derivation of the pertinent Cramér-Rao Lower Bound (CRLB), and ML consistency conditions for the proposed sparse nonlinear model. The proposed ML approach lends itself naturally to <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\ell_1$</tex></formula> -type convex relaxations which are well-suited for distributed implementation, based on the alternating direction method of multipliers (ADMM). A particular decomposition is advocated which bypasses the apparent need for outlier communication, thus maintaining scalability. The performance of the proposed ML approach is demonstrated by comparing against the associated CRLB and prior state-of-the-art using both synthetic and real data sets.
An FPGA architecture supporting dynamically controlled power gating (2010)

Leakage power is an important component of the total power consumption in FPGAs built using 90 nm and smaller technology nodes. Power gating, in which regions of the chip can be powered down, has been shown to be effective at reducing leakage power. However, previous techniques focus on statically-controlled power gating. In this paper, we propose a modification to the fabric of an FPGA that enables dynamically-controlled power gating, in which logic clusters can be selectively powered-down at run-time. For applications containing blocks with large idle times, this could lead to significant leakage power savings. Our architecture utilizes the existing routing fabric and unused input pins of logic clusters to route the power control signals. No modifications to the existing routing algorithms are required to support the new architecture. We study the area and power tradeoffs by varying the basic architecture parameters of an FPGA, and by varying the size of the power gating regions. We also study the leakage energy savings using a model that characterizes an application in terms of its structure and behavior. We show less than 1% of area overhead for a power gating region size of 3X3 logic tiles. Using the application model, we show that up to 40% leakage energy reduction can be achieved using the proposed architecture for different application parameters, not including power dissipated by the power state controller.
Photochemistry of methylcopper hydride, CH3CuH: wavelength dependence of the product distribution (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemistry of methylcopper hydride, CH3CuH: wavelength dependence of the product distributionJ. Mark Parnis and Geoffrey A. OzinCite this: J. Phys. Chem. 1989, 93, 10, 4023–4029Publication Date (Print):May 1, 1989Publication History Published online1 May 2002Published inissue 1 May 1989https://pubs.acs.org/doi/10.1021/j100347a032https://doi.org/10.1021/j100347a032research-articleACS PublicationsRequest reuse permissionsArticle Views67Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Anatomical, Physiological, and Functional Heterogeneity of the Dorsal Raphe Serotonin System (2018)

Summary The dorsal raphe (DR) constitutes a major serotonergic input to the forebrain, and modulates diverse functions and brain states including mood, anxiety, and sensory and motor functions. Most functional studies to date have treated DR serotonin neurons as a single, homogeneous population. Using viral-genetic methods, we found that subcortical-vs. cortical-projecting serotonin neurons have distinct cell body distributions within the DR and different degrees of coexpressing a vesicular glutamate transporter. Further, the amygdala-and frontal cortex-projecting DR serotonin neurons have largely complementary whole-brain collateralization patterns, receive biased inputs from presynaptic partners, and exhibit opposite responses to aversive stimuli. Gain-and loss-of-function experiments suggest that amygdala-projecting DR serotonin neurons promote anxiety-like behavior, whereas frontal cortex-projecting neurons promote active coping in face of challenge. These results provide compelling evidence that the DR serotonin system contains parallel sub-systems that differ in input and output connectivity, physiological response properties, and behavioral functions.
Optimal Frequency Controller Parameters of Wind Turbines Participating System Frequency Control (2018)

Control of variable speed wind turbines to participate system frequency control has become a new requirement for wind turbines in a high penetrated wind farm power system. This paper focuses on selection of the frequency controller parameters of the wind turbines to improve the frequency control effect. Frequency control method of the wind turbines is presented in this paper. Considering the system frequency response, the synthetic frequency response model is built, a multi-objective function of evaluating the effect of system frequency response is proposed, then genetic algorithm is used to determine the optimal frequency controller parameters. The performance of the frequency control effect with optimal frequency controller parameters of the wind turbines is validated in Matlab/Simulink.