gebhart/patrepeval huggingface dataset:
Study of electro-absorption effects in 1300nm In(Ga)As/GaAs quantum dot materials (2016)

We describe a study of electro-absorption effects in high quality 1300nm InAs/GaAs quantum dot (QD) material grown by molecular beam epitaxy. The photocurrent spectra as a function of electric field is investigated and the quantum confined Stark shift of the QD states is compared to reports for various quantum well (QW) systems (GaAs/AlGaAs, InGaAs/GaAs, InGaAsP/InP). We show that the rate of shift of the QD absorption peak is smaller than that of the reported QW systems (~0.1 meV/kVcm-1 c.f. 0.15-0.2 meV/kVcm- 1) and that the QD ground-state absorption is comparatively insensitive to the applied electric field. We observe a strong QD absorption peak at all biases up to avalanche breakdown, which is not observed in previous reports for these QW systems.
Text Entry Throughput (2019)

Human-computer input performance inherently involves speed-accuracy tradeoffs---the faster users act, the more inaccurate those actions are. Therefore, comparing speeds and accuracies separately can result in ambiguous outcomes: Does a fast but inaccurate technique perform better or worse overall than a slow but accurate one? For pointing, speed and accuracy has been unified for over 60 years as throughput (bits/s) (Crossman 1957, Welford 1968), but to date, no similar metric has been established for text entry. In this paper, we introduce a text entry method-independent throughput metric based on Shannon information theory (1948). To explore the practical usability of the metric, we conducted an experiment in which 16 participants typed with a laptop keyboard using different cognitive sets, i.e., speed-accuracy biases. Our results show that as a performance metric, text entry throughput remains relatively stable under different speed-accuracy conditions. We also evaluated a smartphone keyboard with 12 participants, finding that throughput varied least compared to other text entry metrics. This work allows researchers to characterize text entry performance with a single unified measure of input efficiency.
Outpatient Hysterectomy Volume in the United States (2017)

The perceived decline that has been reported in national hysterectomy volume may represent lack of reporting of surgeries performed in ambulatory settings. This information has considerable implications for business, public health interventions, and insurance carriers among other key stakeholders in women's health care delivery.
How Software Aging affects SDN: A view on the controllers (2014)

Software-Defined Networking proposes a new paradigm by separating the control plane from the data plane. The control plane's main responsibility is deployed in a centralized component called SDN controller. Therefore, the SDN based network becomes dependent on a single functional entity (although it may have multiple instances) in order to accomplish its routing and policy rules. The SDN controller is vulnerable to degradation due to a well-known phenomenon called Software Aging. To the best of our knowledge, this work is the first that assesses the impacts of software aging on current implementation of SDN controllers. We show that such a phenomenon must not be neglected in future software architecture designs and implementations.
Synthesis, Characterization, and Redox Reactivity of Novel Quinone-Containing Polymer (2001)

The synthesis of poly(vinyl hydroquinone), PVHQ, via stable free radical polymerization (SFRP) to give a low-dispersity (1.5) material is described. The electrochemical properties of the resulting material deposited as films onto glassy carbon electrodes have been investigated by cyclic voltammetry. In aqueous acetic acid solution, it was found that as the amount of material ostensibly deposited (Γtheo) increased the ratio Γobs/Γtheo (where Γobs and Γtheo represent the measured and the theoretical surface coverage values, respectively) drastically decreased, indicating that a significant fraction of the quinone sites are electrochemically inactive as the film thickness increases. This was attributed to a small electron transfer rate constant and to the fact that the electron transfer is coupled to proton transfer, so the hydrophobicity of the polymer backbone might adversely affect the accessibility of protons. Using Laviron's theory, the electron-transfer rate constant and the transfer coefficient were determined to be 2.1 s-1 and 0.5, respectively, for a PVHQ film (Γobs = 4.3 × 10-10 mol cm-2) on a glassy carbon electrode in 0.10 M acetic acid solution. The formal potential of the PVHQ film shifted with pH at a rate of 59 mV/pH unit up to pH 6. At higher pH values, the slope decreased to ca. 30 mV/pH unit, suggesting a two-electron/one-proton reaction. The surface pKa value for the first deprotonation reaction was estimated to be 7.8.
Combining prior knowledge and boosting for call classification in spoken language dialogue (2002)

Data collection and annotation are major bottlenecks in rapid development of accurate syntactic and semantic models for natural-language dialogue systems. In this paper we show how human knowledge can be used when designing a language understanding system in a manner that would alleviate the dependence on large sets of data. In particular, we extend BoosTexter, a member of the boosting family of algorithms, to combine and balance hand-crafted rules with the statistics of available data. Experiments on two voice-enabled applications for customer care and help desk are presented.
Interações medicamentosas de fitoterápicos e fármacos: Hypericum perforatum e Piper methysticum (2005)

A utilização de produtos naturais na medicina popular é milenar e persiste até os dias atuais. Entretanto, a idéia de que estes produtos são isentos de toxicidade torna o uso de medicamentos fitoterápicos cada vez maior e indiscriminado. Este trabalho trata de uma revisão sobre as interações que podem ocorrer com a utilização concomitante de Hypericum perforatum L. (erva de são joão) e Piper methysticum F. (kava-kava) com fármacos, podendo levar a sérios efeitos tóxicos, incluindo a fatalidade.
Disruption of microtubules induces formation of actin fibrils in density‐inhibited 3T3 cells. (1993)

In density-inhibited 3T3 fibroblast cultures F-actin is localized almost exclusively at the cell-to-cell borders. Depolymerization of microtubules results in a rearrangement of the F-actin pattern. Numerous actin bundles are formed, most of them are anchored to the cell borders. This rearrangement is preceded by a transient rise in F-actin content.
Fibres and Fibre Yielding Plants (2018)

Unquestionably, fibre yielding plants are second only to the food plants in their usefulness. Primitive tree dwellers and cavemen lived by hunting and foraging over fruits, seeds and roots that nature provided. Wool and hides provided the first clothing to these predecessors of modern man. Long before recorded history, however, primitive man had turned his attention to plant fibres, not only for tying and thatching but eventually for weaving lighter, cooler and more pliable fabrics than skins and hides.
Peptide microarrays for coverage of sequence diversity in monitoring the B cell immune response (TECH2P.911) (2015)

Abstract Pathogens such as HIV or other viruses exhibit considerable sequence diversity as a strategy to escape the host immune system. However, sequence diversity is not limited to infectious agents. The increasing application of DNA sequencing indicates diversity between individuals (germ line mutations) and within individuals (somatic mutations) for many proteins. Such mutations can be connected to diseases such as cancer or autoimmune disease. The knowledge of antibody reactivities within individuals against self and foreign antigens is important for diagnosis, patient stratification, prevention and treatment of disease. Here we describe the application of high content peptide microarrays presenting thousands of peptides to be assayed with ~1µl serum sample of a donor to asses the reactivity pattern of antibodies towards a number of given antigens under consideration of sequence diversity using HIV as an example. A library of 6564 overlapping peptides represents the immunogenic fraction of the HIV proteome and covers the majority of the available sequences from the LANL global HIV-1 database. This high content library enables the assessment of antibody reactivity within different individuals independent on the serotype of the infecting HIV-viruses as well as the breadth and depth of antibody binding after boosting the immune system by vaccination. This concept can be easily adapted to other pathogens as well as self antigens such as tumor-associated antigens.
454. Recognition of Tumor Antigens by In Vitro Developed T Cells from Hematopoietic Stem Cells Retrovirally Transduced with TCR Genes (2006)

Adoptive cell transfer is an effective method for the immunotherapy of patients with metastatic melanoma. Animal studies indicated that the anti-tumor efficacy of adoptively transferred T cells is dependent on their differentiation status. Despite enhanced in vitro anti-tumor properties, more_differentiated effector T cells were less effective for in vivo tumor treatment. Recent advances in T cell in vitro development technologies provide a new opportunity to generate naïve T cells in vitro for the purpose of adoptive immunotherapy. In this study, human CD133+ hematopoietic stem cells (HSC) isolated from cord blood mononuclear cells were transduced with retroviral vectors encoding anti_tumor antigen TCR alpha/beta cDNAs (directed against NY_ESO_1 or p53) and co_cultured with a murine stromal cell line engineered with Notch_1 ligand Delta_1 (OP9_DL1). The cells proliferated and the cell number increased rapidly for the first 6 weeks post co_cultivation (approximately 500_fold expansion) and decreased thereafter. Transduction efficiency was 30% to 90% for NY_ESO_1 TCR and p53 TCR (or GFP) vectors (respectively). The HSCs differentiated into committed T cells as evidenced by the expression of T cell markers, such as CD7, CD1a, CD4, CD8, CD27, CD25, CD62, CD69, CD45RA and CD56. Furthermore, T cell receptor excision circles (TRECs) could be detected by PCR only after the HSCs were co_cultured with OP9_DL1 cell line. CD3 and alpha/beta TCR expression were nearly undetectable for the non_TCR vector transduced groups, but was expressed in the TCR vector_transduced cell populations. These cells manifest both NK cell_like nonspecific killing of tumor cell lines and specific recognition and killing of tumor antigen peptide pulsed cells, as evidenced by cytokine secretion and 51Cr release assay. These results were reproducible using cord blood cells but as of now, we have not been able to successfully generate reactive T cells from CD34+ (or CD133+) bone marrow cells or G_CSF mobilized peripheral blood CD34+ (or CD133+) cells.
Abstract IA18: North Carolina Central University and Duke Cancer Institute's collaborative cancer research and education program: Connecting cancer disparities translational research, clinical trials operations, and community engagement (2020)

Abstract Three interrelated contributors to cancer disparities include the lack of diversity among investigators contributing to cancer research, the deficiency of minority participation in clinical trials and bio-banking, and the need to advance community engagement as a vital component of the translational research spectrum. The North Carolina Central University and Duke Cancer Institute's Cancer Disparities Translational Research Partnership (NCCU-DCI CDTRP) (P20 PACHE), through its Cancer Research and Education Program (C-REP), provides a Translational Immersion Experience (TIE) that spans the full translational research spectrum, for traditionally under-represented PhD students, postdoctoral fellows, and early-stage investigators. The goals of TIE are to (1) provide cancer disparities research training with an emphasis on translational laboratory science including high-throughput screening/drug discovery, (2) equip trainees with unique training and education in the operational infrastructure that supports clinical research and trials, (3) highlight strategies to increase diverse participation in clinical trials and bio banking, and (4) learn and apply principles of community engagement through community-based programs and outreach. Using multimodal training techniques, the TIE program provides training and education in real-life settings that expose trainees to the full translational research spectrum across two diseases that disproportionality affect African Americans at significantly higher rates, prostate cancer and inflammatory breast cancer. The overarching goal is to bolster our trainees' experiences and training to contribute to innovative technologies and discoveries and provide access to training that spans beyond the traditional curriculum in areas of high need in translational cancer disparities research such as minority accrual and clinical trials operations. The program includes evidence-based workshops in healthy mentor-mentee relationships, building and sustaining resilience, and sharpening grantwriting skills coupled with ongoing external evaluation to provide real-time feedback on the program. We present the preliminary evaluation data based on the first cohort of the C-REP TIE program. Citation Format: Kevin P. Williams, Nadine J. Barrett, Carla E. Oldham, Holly Hough, Artis Woodard, Jennifer Freedman, Gayathri R. Devi, Steven R. Patierno. North Carolina Central University and Duke Cancer Institute's collaborative cancer research and education program: Connecting cancer disparities translational research, clinical trials operations, and community engagement [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr IA18.
Learning Isometric Separation Maps (2009)

Maximum Variance Unfolding (MVU) and its variants have been very successful in embedding data-manifolds in lower dimensional spaces, often revealing the true intrinsic dimension. In this paper we show how to also incorporate supervised class information into an MVU-like method without breaking its convexity. We call this method the Isometric Separation Map and we show that the resulting kernel matrix can be used as a binary/multiclass Support Vector Machine-like method in a semi-supervised (transductive) framework. We also show that the method always finds a kernel matrix that linearly separates the training data exactly without projecting them in infinite dimensional spaces. In traditional SVMs we choose a kernel and hope that the data become linearly separable in the kernel space. In this paper we show how the hyperplane can be chosen ad-hoc and the kernel is trained so that data are always linearly separable. Comparisons with Large Margin SVMs show comparable performance.
Reduction of aliasing ambiguities through phase relations (1992)

A method for digital determination of a single frequency from a sine wave sampled at less than the Nyquist rate is discussed. The method makes use of phase shift information to eliminate the aliasing ambiguity. Multiple sampled data are required to eliminate ambiguity completely. Computer modeling using simulated data corrupted by uncorrelated Gaussian noise was used to verify the approach. The results demonstrate that the frequency of an input sine wave can be correctly identified. This approach can be applied to electronic warfare (EW) receivers to increase their input bandwidth.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Conformation, Lifetime, and Repair of 4‘-DNA Radicals (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTConformation, Lifetime, and Repair of 4'-DNA RadicalsBernd Giese, Adrian Dussy, Eric Meggers, Mario Petretta, and Urs SchwitterView Author Information Department of Chemistry, University of Basel St. Johanns-Ring 19, CH-4056 Basel, Switzerland Cite this: J. Am. Chem. Soc. 1997, 119, 45, 11130–11131Publication Date (Web):November 12, 1997Publication History Received8 August 1997Published online12 November 1997Published inissue 1 November 1997https://doi.org/10.1021/ja972769qCopyright © 1997 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views284Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (93 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Conformation,Crystal cleavage,Genetics,Monomers,Stereoselectivity Get e-Alerts
Sensor Applications at NASA KSC (2002)

The selection and qualification of commercial off-the-shelf products (COTS) transducers is desired whenever possible. In reality, qualified transducers are modified COTS to comply with KSC and program requirements. These requirements are dictated by the different NASA programs and the Kennedy Space Center (KSC). In some instances, there are no available commercial products that will meet the specific requirements of the application. The KSC Transducers Laboratory then develops these products. When fully developed, these products become certified GSE equipment and the potential for commercialization is assessed and pursued.
Thread Warping (2011)

We introduce thread warping, a dynamic optimization technique that customizes multicore architectures to a given application by dynamically synthesizing threads into custom accelerator circuits on FPGAs (Field-Programmable Gate Arrays). Thread warping builds upon previous dynamic synthesis techniques for single-threaded applications, enabling dynamic architectural adaptation to different amounts of thread-level parallelism, while also exploiting parallelism within each thread to further improve performance. Furthermore, thread warping maintains the important separation of function from architecture, enabling portability of applications to architectures with different quantities of microprocessors and FPGAs, an advantage not shared by static compilation/synthesis approaches. We introduce an approach consisting of CAD tools and operating system support that enables thread warping on potentially any microprocessor/FPGA architecture. We evaluate thread warping using a simulator for high-performance computing systems with different interconnections in addition to multicore embedded systems having between 4 and 64 ARM11 microprocessors. On average, thread warping achieved approximately 3x speedup compared to a high-performance quad-core Intel Xeon and 109x compared to an embedded system consisting of 4 ARM11 cores, with a size cost approximately equal to 36 ARM11 cores.
Behavior of protonated cyclopropyl intermediates during polyalphaolefin synthesis: Mechanism and predicted product distribution (2012)

A new mechanism for the origin of multiple skeletal isomers observed in the cationic dimerization of 1‐decene is proposed, and products that should form based on this mechanism are predicted. A protonated cyclopropyl intermediate appeared to form directly from combination of 2‐decyl carbocation with 1‐decene; formation of this intermediate did not appear to occur via ring closure of a branched secondary carbocation. The authors propose that rapid, repeated isomerizations of the protonated cyclopropyl intermediates lead to multiple skeletal isomers in decene dimers. The proposed mechanism can account for structures previously identified in mixtures of decene dimers and butene dimers. Copyright © 2012 John Wiley &amp; Sons, Ltd.
Pyroprocess Facility Design for a Nuclear Fuel Cycle (2013)

The Korea Atomic Energy Research Institute (KAERI) has been developing pyroprocess for the dry conditioning of PWR spent nuclear fuels since 1997. The ACPF (Advanced spent fuel Conditioning Process Facility) was developed for volume reduction research on spent PWR fuel. Several years later, the PRIDE (PyRoprocess Integrated inactive Demonstration) facility was also developed for SFR fuel utilization research by pyroprocessing. An integrated full pyroprocess was used in the PRIDE facility. Presently another pyroprocess facility, ESPF (Engineering Scale Pyroprocess Demonstration Facility), is being conceptually designed for the future demonstration of an engineering-scale pyroprocess.
Silica nanoparticles as a delivery system for nucleic acid-based reagents (2009)

The transport of nucleic acid-based reagents is predicated upon developing structurally stable delivery systems that can preferentially bind and protect DNA and RNA, and release their cargo upon reaching their designated sites. Recent advancements in tailoring the size, shape, and external surface functionalization of silica materials have led to increased biocompatibility and efficiency of delivery. In this Feature Article, we highlight recent research progress in the use of silica nanoparticles as a delivery vehicle for nucleic acid-based reagents.
Localised Tuneable Composition Single Crystal Silicon-Germanium-on-Insulator for Low Cost Devices (2016)

The realisation of high quality silicon-germanium-on-insulator (SGOI) is a major goal for the field of silicon photonics because it has the potential to enable extremely low power active devices functioning at the communication wavelengths of 1.3 μ m and 1.55 μ m. In addition, SGOI has the potential to form faster electronic devices such as BiCMOS transistors and could also form the backbone of a new silicon photonics platform that extends into the mid-IR wavelengths for applications in, amongst others, sensing and telecoms. In this paper, we present a novel method of forming single crystal, defect-free SGOI using a rapid melt growth technique. We use tailored structures to form localised uniform composition SGOI strips, which are suitable for the state-of-the-art device fabrication. This technique could pave the way for the seamless integration of electronic and photonic devices using only a single, low cost Ge deposition step.
Englishes, English creoles and their negative indefinites (2017)

This is a typological study of negative indefinites, i.e., the counterparts to standard English nobody and nothing, in Englishes, primarily the New Englishes, and in English Creoles. Particular attention goes to “Negative Concord” (“NC”), i.e. the exponence of negation through both a negative indefinite and a verbal negator. The study confirms that NC is widespread in both Englishes and English Creoles and claims that although this holds for both Englishes and English Creoles, they have to be considered separately and that there is a lot of variation with respect to NC subtypes. Important, but mostly for the New Englishes, is whether or not the British English input allowed NC. For Creoles special attention goes to the fact that they typically have created a new verbal negator (no).