gebhart/patrepeval huggingface dataset:
Endoscopic Therapy of Small Bowel Polyps in Cowden Syndrome using Double-Balloon Enteroscopy: A Case Series (2012)

Purpose: Cowden syndrome (CS) is a rare genetic condition with hamartomatous polyposis. It has 30% small bowel involvement which may cause intussusception and other complications. Based on our systematic literature search using PubMed, Embase and Scopus; successful use of double-balloon enteroscopy (DBE) for small bowel polyps in CS patients has only been reported twice. The largest series comprise of only 2 pediatric cases (Urs et al., Arch Dis Child, 2011). In this case series, we aim to report the feasibility and safety of DBE for removal of large intestinal polyps in CS patients. Methods: We retrieved CS cases from a database of 642 DBE procedures at a tertiary referral center. Demographic factors and endoscopy outcomes were recorded. Results: We identified 3 CS patients who underwent a total of 4 DBE procedures. All patients met the National Comprehensive Cancer Network diagnostic criteria for CS. Table 1 summarizes the patients' characteristics. Patient 1 and 3 had small bowel polyps > 1 cm, detected on prior CT enterography. Patient 2 was referred for DBE for surveillance after establishing the diagnosis of CS. Both patients 2 and 3 had prior episodes of intussusception. Patient 3 required partial small bowel resection as a child from intestinal obstruction. DBE was performed by 2 interventional endoscopists using the Fujinon double-balloon enteroscopy system. General anesthesia was used for sedation for all DBE procedures. Endoscopic resection of large intestinal polyps was successful on all 4 DBE procedures. Patient 1 and 3 each had a single antegrade (oral approach) DBE, reaching up to the distal jejunum. Patient 2 required two separate sessions (antegrade followed by a retrograde approach), yielding 30 polyps for each session. Maximum size of resected polyps range from 1 to 3.4 cm. Procedure duration was 2-3.5 hrs. All endoscopically resected polyps were hamartomatous growths, confirmed by histopathology. There were no complications. All 3 patients have been followed for 23 to 36 mos. without any repeat intussusception, bleeding or small bowel obstruction.Table: [1768] Table 1. Patient CharacteristicsConclusion: In this case series, DBE provided successful and safe endoscopic removal of small bowel polyps in patients with CS. Consistent with CS, all intestinal polyps retrieved did not have any evidence of dysplasia.
An algebraic approach to automatic construction of structural models (1993)

We present algebraic approach to the inductive learning of structural models and automatic construction of shape prototypes for character recognition on the basis of the algebraic description of curve structure proposed by Nishida and Mori (1991, 1992). A class in the structural models is a set of shapes that can be transformed continuously to each other. We consider an algebraic representation of continuous transformation of components of the shape, and give specific properties satisfied by each component in the class. The generalization rules in the inductive learning are specified from the viewpoints of continuous transformation of components and relational structure among the components. The learning procedure generalizes a pair of classes into one class incrementally and hierarchically in terms of the generalization rules. We show experimental results on handwritten numerals.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus. (1996)

The pre-T-cell receptor, composed of the T-cell receptor (TCR) beta chain (TCRbeta), pre-Talpha (pTalpha) chain, and CD3 molecules, has been postulated to be a transducer of signals during the early stages of T-cell development. To examine the function of the transmembrane pTalpha chain during tbymocyte development, we generated pTalpha-/- embryonic stem cells and assayed their ability to differentiate into lymphoid cells in vivo after injection into recombination-activating gene (RAG)-2-deficient blastocysts. Thymocytes representing all stages of T-cell differentiation were detected in the thymus of pTalpha-/- chimeric mice, indicating that thymocyte development can occur without pTalpha. However, greatly reduced thymocyte numbers and substantially increased percentages of both CD4-CD8- thymocytes and TCRgammadelta+ thymocytes suggest that pTalpha plays a critical role in thymocyte expansion. To investigate the role of the pTalpha chain in allelic exclusion at the TCRbeta locus, a functionally rearranged TCRbeta minigene was introduced into pTalpha-/- and pTalpha+/- embryonic stem cells, which were subsequently assayed by RAG-2-deficient blastocyst complementation. In the absence of pTalpha, expression of the transgenic TCRbeta inhibited rearrangement of the endogenous TCRbeta locus to an extent similar to that seen in normal TCRbeta transgenic mice, suggesting that pTalpha may not be required for signaling allelic exclusion at the TCRbeta locus.
Correlation between high salivary pepsin concentration and chronic pharyngitis. (2018)

<b>Background:</b> Chronic pharyngitis is long-term inflammation and irritation of the pharynx. Its cause can be multifactorial. In this preliminary study, the aim was to determine if there was a correlation between chronic pharyngitis patients and high concentrations of salivary pepsin. Pepsin is a biomarker of gastroesophageal reflux disease (GERD). Pepsin can cause severe throat pain due to inflammation, directly from pepsin entering the airways. <b>Methods:</b> 32 patients diagnosed with chronic pharyngitis were recruited from the Department of ENT of BenQ Medical Centre and the Department of ENT at The Affiliated Jinling Hospital of Nanjing University Medical School, China. Patients completed the Reflux Symptom Index (RSI), Reflux Finding Score (RFS) and Reflux Disease Questionnaires (RDQ) which describe typical reflux symptoms. Patients provided a total of 96 saliva samples in the morning, postprandial and after symptoms. Pepsin concentration in saliva samples was determined using PEPTEST<sup>TM</sup> a rapid, non-invasive lateral flow device (RD Biomed Limited, UK) which contains two unique human pepsin monoclonal antibodies. <b>Results:</b> 78% pepsin positivity was found (medium (&gt;75 ng/ml) to high (≥500 ng/ml)) and all patients provided at least one positive sample. Reflux questionnaires are not a specific method for the diagnosis of GERD and there was no significant difference between positive RSI or RFS scores and a high salivary pepsin concentration. <b>Conclusion:</b> PEPTEST<sup>TM</sup> allowed for a non-invasive, reliable method for the diagnosis of GERD and measurement of salivary pepsin concentrations. The medium to high concentrations of pepsin found in patients could be a contributing factor to the cause of chronic pharyngitis.
A 12&#x2013;18 GHz electrostatically tunable liquid metal RF MEMS resonator with quality factor of 1400&#x2013;1840 (2011)

In this paper we present a novel tunable RF MEMS resonator that is based upon electrostatic control over the morphology of a liquid metal droplet (LMD). We demonstrate a LMD evanescent-mode cavity resonator that simultaneously achieves wide analog tuning from 12 to 18 GHz with a measured quality factor of 1400-1840. A droplet of 250-μm diameter is utilized and the applied bias is limited to 100 V. This device operates on a principle called Electro-Wetting On Dielectric (EWOD). The liquid metal employed is a non-toxic eutectic alloy of Gallium, Indium and Tin known as Galinstan. This device also exploits interfacial surface energy and viscous body forces that dominate at nanoliter scale.
The Amazing Mysteries of the Gutter: Drawing Inferences Between Panels in Comic Book Narratives (2017)

Visual narrative is often a combination of explicit information and judicious omissions, relying on the viewer to supply missing details. In comics, most movements in time and space are hidden in the gutters between panels. To follow the story, readers logically connect panels together by inferring unseen actions through a process called closure. While computers can now describe the content of natural images, in this paper we examine whether they can understand the closure-driven narratives conveyed by stylized artwork and dialogue in comic book panels. We collect a dataset, COMICS, that consists of over 1.2 million panels (120 GB) paired with automatic textbox transcriptions. An in-depth analysis of COMICS demonstrates that neither text nor image alone can tell a comic book story, so a computer must understand both modalities to keep up with the plot. We introduce three cloze-style tasks that ask models to predict narrative and character-centric aspects of a panel given n preceding panels as context. Various deep neural architectures underperform human baselines on these tasks, suggesting that COMICS contains fundamental challenges for both vision and language.
Performance of interference mitigation scheme for MB-OFDM with Time-Domain Spreading using Adaptive Symbol Skipping (2010)

In this paper, Adaptive Symbol Skipping (AdSS) that is a collision avoidance scheme in multiband-OFDM (MB-OFDM) is evaluated. AdSS skips symbol transmission when a transmitter detects a signal from the other piconets. In the earlier work for AdSS, the probability of symbol loss has been analyzed in the case when no Time-Domain Spreading (TDS) is used. However, for the low data-rate modes of the MB-OFDM standard the symbol skipping may not effective because of TDS. Therefore, in this paper, the performance of AdSS for the MB-OFDM system with TDS is evaluated through theoretical analysis and numerical results obtained by computer simulation.
Interaction with Olefins of the Partially Polarized Surface of Silver Nanoparticles Activated by p‐Benzoquinone and Its Implications for Facilitated Olefin Transport (2007)

Silver nanoparticles activated by electron acceptors, such as p-benzoquinone, are used as olefin carriers for facilitated olefin transport. Poly(ethylene-co-propylene) (EPR)–Ag0–p-benzoquinone (p-BQ) membranes show good separation performance of propylene–propane mixtures over periods longer than 100 hours. The ideal separation factor through 1:1:X EPR/Ag0/p-BQ membranes with varying weight ratios of p-BQ to EPR is shown in the figure.
Potential of Protein-based Anti-metastatic Therapy with Serpins and Inter α-Trypsin Inhibitors (2018)

In this review we summarize the principles of anti-metastatic therapy with selected serpin family proteins, such as pigment epithelial-derived factor (PEDF) and maspin, as well as inter α-trypsin inhibitor (IαIs) light chains (bikunin) and heavy chains (ITIHs). Case-by-case, antimetastatic activity may be dependent or independent of the protease-inhibitory activity of the corresponding proteins. We discuss the incidence of target deregulation in different tumor entities, mechanisms of deregulation, context-dependent functional issues as well as in vitro and in vivo target validation studies with transfected tumor cells or recombinant protein as anti-metastatic agents. Finally, we comment on possible clinical evaluation of these proteins in adjuvant therapy.
Sub-20 nm design technology co-optimization for standard cell logic (2014)

Efficiency and manufacturability of standard cell logic is critical for an IC, as standard cells are at the heart of the nexus between technology definition, circuit design and physical synthesis. Conventional standard cell design techniques are increasingly ineffective as we scale to patterning restricted sub-20 nm CMOS nodes. To meet the constraints and leverage the features of future technology offerings, we propose a holistic design technology co-optimization (DTCO) for standard cell logic. In our holistic DTCO we co-optimize the standard cell architecture to balance manufacturability and efficiency at the cell level while taking into account block level considerations such as pin accessibility and power rail robustness. Our DTCO in a foundry 14 nm CMOS resulted in two standard cell architectures, namely, 10T_BiDir and 10T_UniDir. We evaluated these cell libraries with physically synthesized blocks and ring oscillator test structures in IBM 14SOI process. We observed that 10T_BiDir emerges as the preferred alternative at 14 nm CMOS, with 10T_UniDir promising better scalability to future nodes.
A method to classify the signals from artificially prepared defects in GIS using the decision tree method (2005)

On-line diagnosing of GIS (gas insulated switchgears) requires the pattern classification and identification of signals that are emitted from GIS. To classify the patterns correctly, substantial data sets that are emitted by artificially mimicked defects in GIS are needed. Applying the neural networks to the data sets, in general, identification methods of defects in GIS have widely been developed. Some identification system shows a good success such that the misclassification rate is reduced to below 5%; the key features in identification, however, are not obviously revealed in neural networks systems because of nonlinear network structures. The decision tree method that classifies the signals using the feature rules in plain graphical representations can explains the classification rules in clear forms. We applied the decision tree classification method to the signals emitted from the signals by artificially prepared defects in GIS, and find that the method shows a good classification rates over 95% which are comparable to that in neural networks. We also discuss the robustness from noise, and compare the results of the misclassification rates by the two methods.
Impact of Alcohol Consumption on Atrial Fibrillation Outcomes Following Pulmonary Vein Isolation (2016)

Despite known associations between alcohol and incidence of AF, alcohol consumption is not associated with early or late AF recurrence after PVI in this cohort.
Modulator integration in high-performance BiCMOS (2013)

We present results for FEOL integration of Silicon electro-optic waveguides with high-performance BiCMOS technology. The new technology allows for dense co-integration of high-speed analogue RF circuits and Silicon modulators.
Supplementary Figure 5 from A Preclinical Trial and Molecularly Annotated Patient Cohort Identify Predictive Biomarkers in Homologous Recombination–deficient Pancreatic Cancer (2023)

&lt;p&gt;Supplementary Figure 5 shows the immunohistochemical analysis of apoptotic activity in xenografts treated with gemcitabine mono- and combination therapies&lt;/p&gt;
Seq-2-Seq based Refinement of ASR Output for Spoken Name Capture (2022)

Person name capture from human speech is a difficult task in human-machine conversations. In this paper, we propose a novel approach to capture the person names from the caller utterances in response to the prompt "say and spell your first/last name". Inspired from work on spell correction, disfluency removal and text normalization, we propose a lightweight Seq-2-Seq system which generates a name spell from a varying user input. Our proposed method outperforms the strong baseline which is based on LM-driven rule-based approach.
Fibre-tip displacement sensor using sinusoidal FM-based technique (1991)

A frequency modulated dual-electrode DFB laser is used as the optical source for a sensor which is immune to polarisation and acoustic fluctuations affecting its fibre-optic leads. Detection of the quadrature components of the reflected signal allows unambiguous direction determination. A measurement accuracy of ± 20nm is demonstrated over a range of several millimetres.
A Design of PLC-Based 6-Mode Exchanger in Mode Division Mulutiplexed Transmission (2019)

A 6-mode exchanger composed of cascaded long-period-grating waveguide is proposed for mode-division-multiplexing system. Theoretical design shows low-loss and highly efficient mode exchanging operation is possible. Total mode dependent loss of the system is reduced for multiple exchanging operations in few-mode-fiber transmission.
A Small-Molecule Furin Inhibitor Inhibits Cancer Cell Motility and Invasiveness (2008)

Furin, a member the proprotein convertase (PC) family, processes inactive precursor proteins to functional proteins within the Golgi/trans-Golgi network secretory pathway. Furin and other PC family members (furin/PCs) activate proteins vital to proper physiological functioning, including growth factors and hormones, receptors, plasma proteins, and matrix metalloproteases (MMPs). Additionally, the expression and activity of furin/PC are necessary for processing substrates important for cell transformation and tumor progression, metastasis, and angiogenesis. Furin processing of the remodeling protease membrane type-1 matrix metalloproteinase (MT1-MMP) enhances cellular motility and invasiveness, contributing to aggression and metastatic potential cancer cells. Whereas overexpression and activity of furin/PC exacerbate the cancer phenotype, inhibition of its activity decreases or nullifies furin/PC-mediated effects, and thus, inhibition of furin may be a viable route to cancer therapy. Recently, we identified a small-molecule inhibitor of furin, named B3, by high-throughput screening with a K(i) and IC(50) of 12 microM. Here, we show that this cell-permeable, small-molecule compound inhibits furin-mediated cleavage of proMT1-MMP, resulting in decreased MMP-2 activation and cell motility in CHO cells expressing proMT1-MMP. Additionally, this molecule inhibited proMT1-MMP processing, complete MMP-2 maturation, and invasiveness of human fibrosarcoma cells (HT1080).
Ce3+-based phosphors for blue LED excitation (2004)

The luminescence of Ce<sup>3+</sup> in host lattices based on Y<sub>3</sub>Al<sub>5</sub>O<sub>12</sub> garnets that can be used in blue LED based solid state lighting sources is discussed. Specifically, the effect of Ga<sup>3+</sup> and Tb<sup>3+</sup> substitution for Al<sup>3+</sup> and Y<sup>3+</sup>, respectively, on the emission color and thermal quenching of these phosphors is described with the initial implications for white light devices.
Solid-Phase Synthesis with Tris(alkoxy)benzyl Backbone Amide Linkage (BAL)[≠] (1999)

The novel and general BAL concept allows for solid-phase synthesis of C-terminal-modified and cyclic peptides, small organic molecules, and modified amino sugars, as single species or as part of combinatorial chemistry applications. A BAL anchor attached to resin is depicted.
Predicting Failure Distributions of SRAM Arrays by Using Extreme Value Statistic, Bit Cell Simulation, and Machine Learning (2023)

We present a successful methodology for accurately predicting failure distributions of SRAM arrays based on simulation results of a single bit cell. This was achieved by using extreme value statistic and a data-centric approach of supervised machine learning. The purpose of such predictions is to enable assessments of the trade-off between optimizing power, performance, and area (PPA) and safeguarding reliability in an early phase of development.
Supplementary Figure 6 from Measles Virus Vaccine–Infected Tumor Cells Induce Tumor Antigen Cross-Presentation by Human Plasmacytoid Dendritic Cells (2023)

&lt;p&gt;PDF file - 214K, Supplemental Figure 6: Monocyte-derived DC exhibit a similar level of NYESO-1 cross-presentation compared to pDC. (A) on day0, pDC and monocytes from a single donor were purified. pDC were frozen and monocytes cultured with IL-4 and GM-CSF. On day 5, pDC were thawed. pDC and monocyte-dervied DC were cultured alone or with UV-irradiated M18 (M18UV) or MV-infected M18 (M18MV) for 18hrs. On day6, DC were cultured with the NYESO-1 specific CD8+ T cell clone during 6hrs in presence of brefeldinA. Cells were then stained with anti-CD8+ antibody, fixed, permeabilized and stained with IFN-g specific antibody. IFN-g secretion by the the T cell clone was analyzed by flow cytometry. We conclude that level of cross-presentation was somewhat similar between the two cell types. It was a little bit weaker for pDC, but these cells have been frozen, whereas Monocyte-derived DC were not. (B) scatter plot representation of three cross-presentation experiments performed with monocyte-derived DC. Error bars represent standard deviation.&lt;/p&gt;
A career working with Jim Wyant (2021)

Upon entering graduate school, I wanted to ensure real world experience prior to graduation. Fortunately, Jim Wyant was willing to accept me as a student, working with him at Wyko Corporation. After graduating I stayed on as an optical engineer, product manager, and eventually engineering and research director as the company was acquired by Veeco and eventually Bruker. Meanwhile Jim Wyant had brought another optics company to Tucson, 4D Technology, with unique technology developed by James Millerd and Neal Brock. That organization was growing well, with many former Wyko/Veeco employees, and as Bruker's Tucson business changed, I moved to help grow it further, staying in the Wyant ecosystem. This talk will focus on my journey under Jim's companies, including key milestones and stories from my own experience and those of some of the other long-term employees of Wyant’s optical enterprises.
POWER AMPLIFIER DESIGN DEDICATED TO UMTS (3G) APPLICATIONS IN 65 NM TECHNOLOGY (2010)

International audience
Sources optiques au bruit de grenaille : fonctionnement monofréquence et bifréquence pour les liaisons optos (2009)

National audience
Long-Term Safety and Efficacy of Tadalafil 5 mg Dosed Once Daily in Men with Erectile Dysfunction (2008)

In these long-term, open-label, once-daily dosing studies, tadalafil 5 mg was well tolerated and effective, making it a viable alternative to the current on-demand dosing of tadalafil for men with ED.
Optical phase conjugation for ultra long-haul phase-shift-keyed transmission (2006)

Nonlinear phase noise (Gordon-Mollenauer phase noise) can limit the transmission distance for phase-shift-keyed modulation formats. In this paper, the compensation of nonlinear phase noise by a midlink optical phase conjugation (OPC) is studied. A proof-of-principle experiment is presented showing an over 4-dB improvement in Q factor when OPC is employed in a differential phase-shift-keying (DPSK) system. Also, an ultra long-haul OPC-based differential quadrature phase-shift-keying (DQPSK) transmission experiment is studied to show the impact of self-phase modulation (SPM)-induced impairments, including nonlinear phase noise, in a transmission line. OPC results in a 44% increase in transmission distance when compared to a "conventional" transmission system using dispersion compensating fiber (DCF) for chromatic dispersion compensation.
ChunkyGAN: Real Image Inversion via Segments (2022)

We present ChunkyGAN—a novel paradigm for modeling and editing images using generative adversarial networks. Unlike previous techniques seeking a global latent representation of the input image, our approach subdivides the input image into a set of smaller components (chunks) specified either manually or automatically using a pre-trained segmentation network. For each chunk, the latent code of a generative network is estimated locally with greater accuracy thanks to a smaller number of constraints. Moreover, during the optimization of latent codes, segmentation can further be refined to improve matching quality. This process enables high-quality projection of the original image with spatial disentanglement that previous methods would find challenging to achieve. To demonstrate the advantage of our approach, we evaluated it quantitatively and also qualitatively in various image editing scenarios that benefit from the higher reconstruction quality and local nature of the approach. Our method is flexible enough to manipulate even out-of-domain images that would be hard to reconstruct using global techniques.