gebhart/patrepeval huggingface dataset:
Predicated array data-flow analysis for run-time parallelization (1998)

This paper presents a new analysis for parallelizing compilers called predicated array data-flow analysis, whereby array dataflow analysis for parallelization and privatization is extended to associate predicates with data-flow values. These predicates can be used to derive conditions under which dependences can be eliminated or privatization is possible. These conditions, which can consist of arbitrary program statements, can be used both to enhance compile-time analysis and to introduce run-time tests that guard safe execution of a parallelized version of a computation.
Accelerating Palladium‐Catalyzed CF Bond Formation: Use of a Microflow Packed‐Bed Reactor (2011)

Ein Strömungsprozess für Pd-katalysierte C-F-Bindungsbildungen wird beschrieben. Ein Festbettmikroreaktor ermöglicht es, große Mengen an unlöslichem CsF zu handhaben – bei präziser Kontrolle der Reaktionszeiten, effizientem Mischverhalten und der Möglichkeit zur sicheren Anwendung hoher Temperaturen und Drücke. Eine Vielzahl von Aryltriflaten, einschließlich Heteroarylen, wurde in kurzen Reaktionszeiten in Arylfluoride überführt (siehe Schema). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Sanguinarine, a Benzophenanthridine Alkaloid, Induces Apoptosis in MDA-MB-231 Human Breast Carcinoma Cells through a Reactive Oxygen Species-Mediated Mitochondrial Pathway (2008)

Our data imply that sanguinarine-induced ROS are key mediators of MMP collapse, which leads to the release of cytochrome c followed by caspase activation, culminating in apoptosis.
Multiscale Decomposition of Cardiovascular and Cardiorespiratory Information Transfer under General Anesthesia (2018)

The analysis of short-term cardiovascular and cardiorespiratory regulation during altered conscious states, such as those induced by anesthesia, requires to employ time series analysis methods able to deal with the multivariate and multiscale nature of the observed dynamics. To meet this requirement, the present study exploits the extension to multiscale analysis of recently proposed information decomposition methods which allow to quantify, from short realizations, the amounts of joint, unique, redundant and synergistic information transferred within multivariate time series. These methods were applied to the spontaneous variability of heart period (HP), systolic arterial pressure (SAP) and respiration (RESP) in patients undergoing coronary artery bypass graft monitored before and after the induction of general anesthesia. We found that, after anesthesia induction, information is processed within the cardiovascular network in a scale-dependent way: at short time scales, a shift from synergistic to redundant information transferred from SAP and RESP to HP occurs, which is associated with enhanced baroreflex-mediated respiratory effects on arterial pressure; at longer time scales, the increased information transfer from SAP to HP denotes an enhancement of the baroreflex coupling related to slow cardiovascular oscillations.
220 fs Er-Yb:glass laser mode-locked by a broadband low-loss Si/Ge saturable absorber (2005)

We report a silicon/germanium saturable Bragg reflector, compatible with CMOS processing. Its sub-picosecond recovery time enables a C-band spanning mode-locked Er-Yb:glass laser at 1540 nm, generating 220 fs pulses.
Valutazione epidemiologica dello screening mammografico 'Per te donna' nell'ASL della provincia di Varese (2012)

Nel corso del 2000 e stato avviato, nell’ASL della Provincia di Varese, lo screening mammografico per tutte le donne residenti, di eta compresa tra i 50 - 69 anni. In questo lavoro si valuta sinteticamente l’andamento dello screening dal 1° di gennaio 2001 fino al 31 dicembre 2002. L’avvio dello screening e stato graduale, iniziando con alcuni comuni della Provincia, fino ad arrivare al coinvolgimento di tutti i 141 comuni. La popolazione bersaglio e risultata essere di 109.607 donne. Nel primo anno sono state invitate 35.161 donne, nel secondo 49.709, con un aumento degli inviti pari al 41,4%. La popolazione rispondente, nel corso del 2001, e stata di 12.992 donne, nel 2002 di 22.590 donne, con un aumento della risposta pari al 73,9 %. L’adesione corretta al programma di screening e passata dal 41,2 % nel 2001 al 54,7 % nel 2002 e il tasso di identificazione (Detection Rate) dal 4,8 ‰ al 5,3 ‰. Sta per iniziare il secondo round del programma di screening. In previsione di questa fase, sulla base dell’esperienza maturata nel primo round, dovranno essere aggiornati le linee guida, il piano di fattibilita e implementato il sistema di controllo di qualita di tutte le componenti del programma (ruolo di gestione e di coordinamento dell’ASL, esecuzione delle prestazioni da parte degli enti erogatori, flussi informativi, comunicazione e formazione di tutto il personale dedicato).
Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells (2020)

Type III interferons (IFN-lambdas(λ)) are important cytokines that inhibit viruses and modulate immune responses by acting through a unique IFN-λR1/IL-10RB heterodimeric receptor. Until now, the primary antiviral function of IFN-λs has been proposed to be at anatomical barrier sites. Here, we examine the regulation of IFN-λR1 expression and measure the downstream effects of IFN-λ3 stimulation in primary human blood immune cells, compared with lung or liver epithelial cells. IFN-λ3 directly bound and upregulated IFN-stimulated gene (ISG) expression in freshly purified human B cells and CD8+ T cells, but not monocytes, neutrophils, natural killer cells, and CD4+ T cells. Despite similar IFNLR1 transcript levels in B cells and lung epithelial cells, lung epithelial cells bound more IFN-λ3, which resulted in a 50-fold greater ISG induction when compared to B cells. The reduced response of B cells could be explained by higher expression of the soluble variant of IFN-λR1 (sIFN-λR1), which significantly reduced ISG induction when added with IFN-λ3 to peripheral blood mononuclear cells or liver epithelial cells. T-cell receptor stimulation potently, and specifically, upregulated membrane-bound IFNLR1 expression in CD4+ T cells, leading to greater antiviral gene induction, and inhibition of human immunodeficiency virus type 1 infection. Collectively, our data demonstrate IFN-λ3 directly interacts with the human adaptive immune system, unlike what has been previously shown in published mouse models, and that type III IFNs could be potentially utilized to suppress both mucosal and blood-borne viral infections.
Dynamic Laser Stimulation Technique for Device Qualification Process (2008)

Abstract A key point to guarantee electronic device quality is device qualification. This part of the process is a significant contributor to the time and cost of the development and production of any electronic device. A device is required to perform a task and its operational lifetime is a key issue for the end user. The more sensitive the qualification technique is, the faster marginalities in the device parameters could be observed. Dynamic Laser Stimulation techniques fill this requirement and could be used in conjunction with traditional qualification procedures.
Data associated with publication “Dopant-Dependent Increase in Seebeck Coefficient and Electrical Conductivity in Blended Polymers with Offset Carrier Energies" (2019)

The strong and counterproductive interrelationship of thermoelectric parameters remains a bottleneck to improving thermoelectric performance, especially in polymer-based materials. In this paper, we decouple the electrical conductivity and Seebeck coefficient, achieving increases in at least one of these two parameters while the other is maintained or slightly increased as well. This is done using an alkylthio-substituted polythiophene (PQTS12) as additive in poly(bisdodecylquaterthiophene) (PQT12) with tetrafluorotetracyanoquinodimethane (F4TCNQ) and nitrosyl tetrafluoroborate (NOBF4) as dopants. The power factor increased two orders of magnitude with the PQTS12 additive at constant doping level. Using a second pair of polymers, poly(2,5-bis(3-dodecylthiophen-2-yl)thieno[3,2-b]thiophene (PBTTTC12) and poly(2,5-bis(3-dodecylthiothiophen-2-yl)thieno[3,2-b]thiophene, (PBTTTSC12), with higher mobilities, we also observed the decoupling of the Seebeck coefficient and electrical conductivity, and achieved higher power factor. Distinguished from recently reported works, these two sets of polymers possess very closely offset carrier energy levels (0.05 ~ 0.07 eV), and the microstructure, assessed using grazing incidence X-ray scattering, and mobility evaluated in field-effect transistors, was not adversely affected by the blending. Experiments, calculations and simulations are consistent with the idea that blending and doping polymers with closely-spaced energy levels and compatible morphologies to promote carrier mobility favors increased power factors.
Immune‐mediated vasomotor dysfunction and ROS production during hypercholesterolemia occurs through an IFN‐γ‐dependent signaling pathway (2008)

Hypercholesterolemia (HC), a risk factor for the development of atherosclerosis, elicits a systemic inflammatory response that is accompanied by endothelium‐dependent vasomotor dysfunction. Although immune‐derived cytokines and the production of reactive oxygen species (ROS) have been implicated in atherogenesis, it remains unclear how these factors contribute to HC‐induced vasomotor dysfunction. We tested the hypothesis that HC elicits immune‐mediated ROS production and endothelial dysfunction through IFN‐γ signaling. Wire myography was employed to assess vasomotor responses and a cytochrome C reduction assay was used to assess ROS production in aortic rings harvested from wild type (WT) or mutant mice placed on either a normal (ND) or cholesterol‐enriched (HC) diet. Bone marrow chimeras (BMC) were produced by marrow transplantation between WT and IFN‐γ‐deficient (IFN‐γ−/−) mice. Endothelium‐dependent vasodilation to Ach was impaired and ROS production was increased in WT and WT→WT BMC mice on HC. The impaired vasodilation and increased ROS production were absent in IFN‐γ−/−, IFN‐γ−/−→WT BMC, and IFN‐γ receptor‐deficient mice on HC diet. Our findings indicate that immune‐mediated endothelium‐dependent vasomotor dysfunction and increased ROS production caused by HC occurs through an IFN‐γ signaling pathway.
A generalized Frank-wolfe approach to decentralized electric vehicle charging (2016)

The uncoordinated charging of large electric vehicle (EV) fleets could have an adverse influence on power network operation. To guarantee the secure and economic operation of power grids, vehicle charging needs to be coordinated to minimize the power supply cost, while catering vehicle charging requests. Provisioning large-scale fleets scheduled at fine timescales, the task of EV scheduling is tackled here by properly adopting the Frank-Wolfe method. Upon devising an optimal step size rule, the novel scheme is shown to enjoy fast convergence rate, especially during the first iterations. The derived charging protocol features affordable computational requirements from vehicle controllers and minimal information exchange between vehicles and their aggregator. To cope with random cyber delays in the communication links between vehicles and the aggregator, an asynchronous version of the charging scheme is also studied. Interpreted as a block stochastic Frank Wolfe algorithm, the latter ensures feasibility across iterations, converges in the mean, and enjoys the same order of convergence rate attained by its synchronous counterpart. Numerical tests demonstrate the advantage of our deterministic scheme over a state-of-the-art projected gradient descent alternative, as well as the robustness of its stochastic counterpart to asynchronous updates.
Ultrafast Sub‐100 fs All‐Optical Modulation and Efficient Third‐Harmonic Generation in Weyl Semimetal Niobium Phosphide Thin Films (2022)

Since their experimental discovery in 2015, Weyl semimetals have generated a large amount of attention due their intriguing physical properties that arise from their linear electron dispersion relation and topological surface states. In particular, in the field of nonlinear (NL) optics and light harvesting, Weyl semimetals have shown outstanding performances and achieved record NL conversion coefficients. In this context, the first steps toward Weyl semimetal nanophotonics are performed here by thoroughly characterizing the linear and NL optical behavior of epitaxially grown niobium phosphide (NbP) thin films, covering the visible to the near-infrared regime of the electromagnetic spectrum. Despite the measured high linear absorption, third-harmonic generation studies demonstrate high conversion efficiencies up to 10<sup>-4</sup> % that can be attributed to the topological electron states at the surface of the material. Furthermore, nondegenerate pump-probe measurements with sub-10 fs pulses reveal a maximum modulation depth of ≈1%, completely decaying within 100 fs and therefore suggesting the possibility of developing all-optical switching devices based on NbP. Altogether, this work reveals the promising NL optical properties of Weyl semimetal thin films, which outperform bulk crystals of the same material, laying the grounds for nanoscale applications, enabled by top-down nanostructuring, such as light-harvesting, on-chip frequency conversion, and all-optical processing.
Efficient Implementation of 2<tex>$times$</tex>Oversampled Exponentially Modulated Filter Banks (2006)

This paper studies 2times oversampled exponentially modulated filter banks because they can be a useful solution for various communications signal processing problems. At first, the perfect reconstruction (PR) property of this kind of 2M-channel complex modulated filter bank is proven by using the results of M-channel PR cosine-/sine-modulated filter banks (CMFBs/SMFBs). Then, two efficient implementation structures are developed. The computational complexities of CMFB/SMFB-based and discrete Fourier transform (DFT)-based realizations are practically the same when comparing the required number of multiplications and additions. However, the DFT-based structures can be further simplified by using an intuitive spectral interpretation. This results in the modified filter bank part that requires less arithmetic operations than the original one
Synthesis and Lithographic Patterning of FePt Nanoparticles Using a Bimetallic Metallopolyyne Precursor (2008)

Mikromuster aus flächenzentriert-tetragonal angeordneten ferromagnetischen FePt-Nanopartikeln können ausgehend von dünnen Filmen einer luft- und feuchtigkeitsbeständigen Polyferroplatindiin-Dimetallvorstufe erhalten werden, die als Negativ-Photolack in Elektronenstrahllithographie und UV-Photolithographie dient.
High-Power InGaN Lasers for Direct Diode Laser Processing (2019)

We achieved 129 W continuous-wave operation of a single-chip InGaN laser in the 400-nm wavelength range. Novel wall-plug-efficiency approximation clarifies the relations between the thermal saturation power and laser parameters, which enable high-power device designs. With the direct diode laser scheme, this short-wavelength light source shows more efficient copper processing than that operating in the 900-nm range.
Data from PET Imaging of TIGIT Expression on Tumor-Infiltrating Lymphocytes (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Therapeutic checkpoint inhibitors on tumor-infiltrating lymphocytes (TIL) are being increasingly utilized in the clinic. The T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is an inhibitory receptor expressed on T and natural killer cells. The TIGIT signaling pathway is an alternative target for checkpoint blockade to current PD-1/CTLA-4 strategies. Elevated TIGIT expression in the tumor microenvironment correlates with better therapeutic responses to anti-TIGIT therapies in preclinical models. Therefore, quantifying TIGIT expression in tumors is necessary for determining whether a patient may respond to anti-TIGIT therapy. PET imaging of TIGIT expression on TILs can therefore aid diagnosis and in monitoring therapeutic responses.&lt;/p&gt;Experimental Design:&lt;p&gt;Antibody-based TIGIT imaging radiotracers were developed with the PET radionuclides copper-64 (&lt;sup&gt;64&lt;/sup&gt;Cu) and zirconium-89 (&lt;sup&gt;89&lt;/sup&gt;Zr). &lt;i&gt;In vitro&lt;/i&gt; characterization of the imaging probes was followed by &lt;i&gt;in vivo&lt;/i&gt; evaluation in both xenografts and syngeneic tumor models in mouse.&lt;/p&gt;Results:&lt;p&gt;Two anti-TIGIT probes were developed and exhibited immunoreactivity of &gt;72%, serum stability of &gt;95%, and specificity for TIGIT with both mouse TIGIT-expressing HeLa cells and &lt;i&gt;ex vivo&lt;/i&gt;–activated primary splenocytes. &lt;i&gt;In vivo&lt;/i&gt;, the &lt;sup&gt;89&lt;/sup&gt;Zr-labeled probe demonstrated superior contrast than the &lt;sup&gt;64&lt;/sup&gt;Cu probe due to &lt;sup&gt;89&lt;/sup&gt;Zr's longer half-life matching the TIGIT antibody's pharmacokinetics. The &lt;sup&gt;89&lt;/sup&gt;Zr probe was used to quantify TIGIT expression on TILs in B16 melanoma in immunocompetent mice and confirmed by &lt;i&gt;ex vivo&lt;/i&gt; flow cytometry.&lt;/p&gt;Conclusions:&lt;p&gt;This study develops and validates novel TIGIT-specific &lt;sup&gt;64&lt;/sup&gt;Cu and &lt;sup&gt;89&lt;/sup&gt;Zr PET probes for quantifying TIGIT expression on TILs for diagnosis of patient selection for anti-TIGIT therapies.&lt;/p&gt;&lt;/div&gt;
The Role of B/T Costimulatory Signals in the Immunopotentiating Activity of Neisserial Porin (1999)

A T cell-dependent immune response to group C meningococcal capsular polysaccharide (CPS) can be elicited when CPS is conjugated to the class 3 neisserial porin (CPS-porin). Treatment of CPS-porin-immunized mice with B7-2 blocking monoclonal antibody (MAb) caused a dramatic reduction in the CPS-specific IgG response, treatment with anti-B7-1 MAb had no effect, and concurrent blockade of B7-1 and B7-2 resulted in a synergistic abrogation of the CPS-specific IgG response while the CPS IgM response was unaffected. Anti-CD40L MAb treatment caused a significant reduction of both CPS-specific IgG and IgM levels. In contrast, blockade of CTLA4 interactions resulted in increases in both CPS IgG and IgM responses in CPS-porin-immunized mice. These data support the hypothesis that the ability of neisserial porins to improve the immune response to poorly immunogenic antigens (e.g., polysaccharides) is related to porin-induced increases in B7-2 expression on antigen-presenting cells and enhanced B/T cell interactions.
Evaluation of Magnetic Materials for Very High Frequency Power Applications (2011)

This paper investigates the loss characteristics of RF magnetic materials for power conversion applications in the 10 to 100 MHz range. A measurement method is proposed that provides a direct measurement of an inductor quality factor <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">QL</i> as a function of inductor current at RF frequencies, and enables indirect calculation of core loss as a function of flux density. Possible sources of error in measurement and calculation are evaluated and addressed. The proposed method is used to identify loss characteristics of several commercial RF magnetic-core materials. The loss characteristics of these materials, which have not previously been available, are illustrated and compared in tables and figures. The use of the method and data is demonstrated in the design of a magnetic-core inductor, which is applied in a 30-MHz inverter. The results of this paper are thus useful for the design of magnetic components for very high frequency applications.
Highly Efficient VQ-Based Normal Map Compression using Quality Estimation Model (2007)

Normal maps play an important role in computer 3D graphics to express pseudo roughness of the surface with a small amount of polygon data. In this paper, a highly efficient normal map compression algorithm is proposed based on an estimation model to predict the quality of the images rendered with the compressed normal maps. The optimal encoding is achieved by minimizing the predicted mean square error (MSE) employing vector quantization (VQ). In addition, encoding and decoding time is fast enough for practical usage. Experimental results demonstrate that the algorithm proposed in this paper yields better compression performance than the other algorithms in the literatures.
Force Control of Human–Robot Interaction Using Twin Direct-Drive Motor System Based on Modal Space Design (2009)

Future robot systems are required to focus on developing more flexible systems for use with human operator. These robots must operate more slowly and be more compliant to safe user interaction. This paper proposes an improved design methodology for the human-robot interaction system. The main contribution of the work described in this paper is the design of dual disturbance observers combined with modal space design for the twin direct-drive motor system. Two of the same direct-drive motors are required and connected by wire rope mechanism. Since both direct-drive motors have almost the same value of the friction effect and other nonlinearities, it is easy for the proposed system to compensate these deterioration effects. The proposed force control system is independently controlled in acceleration dimension by realizing the system based on common mode and differential mode. In the common mode, it is utilized for control of vibration suppression and wire rope tension. Moreover, the bandwidth and the stiffness of mechanism can be regulated by changing the wire rope tension control. In the differential mode, the purity of human external force with compensation of friction force is obtained. This mode is useful for control of the interaction force of human. The effectiveness of the proposed method is verified by experimental results.
Safety and efficacy of a genetic vaccine targeting telomerase plus chemotherapy for B-cell canine lymphoma therapy (2013)

Background. We have recently shown that a genetic vaccine targeting dog telomerase (dTERT) and based on Ad/DNA-EP technology can induce strong immune response and increased overall survival of dogs affected by B-cell malignant lymphoma (ML) in comparison with historical controls when combined with COP chemotherapy regimen.\nObjectives. Here, we have conducted a double arm clinical trial including 21 dogs for each arm, (vaccine vs. control), measured the antigen-specific immune response and evaluated potential toxic effects of the immunotherapy along with following patients survival for three years and half. Methods: Changes in hematological parameters, local/systemic toxicity or organic dysfunction and fever were monitored over time during the treatment. The immune response was measured by ELISPOT.\nResults. No adverse effects attributable to treatment were observed in any dog patient. dTERT- specific immune response was induced in 19 of 21 treated animals. The overall survival time of vaccine/COP treated dogs was significantly increased over contemporaneous COP-treated animals (&gt;76.1 vs 29.3 weeks, respectively, p&lt;0.0001), while no differences were found between the groups regarding the relapse-free interval.\nConclusions. Ad/DNA-EP-based cancer vaccine against dTERT in combination with COP chemotherapy is safe and significantly prolongs the survival of ML canine patients while having no remarkable effect on the relapse-free interval. These data suggest that the dTERT has therapeutic efficacy and support the evaluation of this approach for other cancer types.