gebhart/patrepeval huggingface dataset:
Role of postinduction immunotherapy in acute myeloid leukemia. (1996)

Because chemotherapy alone does not eliminate clonogenic leukemic cells, disease may recur after induction and consolidation chemotherapy. Studies of patients receiving high-dose chemotherapy supported by bone marrow or blood stem-cell transplantation suggest that immune-mediated effects of transplanted cells help control disease. This antileukemic (graft-versus-leukemia) effect represents several immune reactions. Various approaches to introduce or enhance such immune reactivity in patients with acute myeloid leukemia (AML) are being explored. There is some indication, even in older patients, that immunotherapy is better tolerated than chemotherapy, and efforts are underway to find the most effective treatment for maintaining remission after induction chemotherapy. We have developed a strategy that combines myeloablative chemotherapy with transplantation of autologous stem cells that have been cultured for 1 week in interleukin-2. Low-dose interleukin-2 is also administered for the first week after stem cell infusion. Although all patients developed side effects of fever and fatigue, even older patients tolerated this regimen well. The 3-year disease-free survival rate in a high-risk patient group transplanted in early first remission is 41 percent. Several other compounds are being investigated for their ability to enhance immune reactions after induction chemotherapy for AML. Although immunotherapy cannot eliminate overt leukemia and cytoreductive treatment is still needed initially, immunotherapy may find a place in postinduction management of AML to eliminate minimal (residual) disease or control its growth.
Safety of Intravenous Administration of an AAV8 Vector Coding for an Oxidation-Resistant Human α1-Antitrypsin for the Treatment of α1-Antitrypsin Deficiency (2023)

α1-antitrypsin (AAT) deficiency is a common autosomal recessive hereditary disorder, with a high risk for the development of early-onset panacinar emphysema. AAT, produced primarily in the liver, functions to protect the lung from neutrophil protease; with AAT deficiency, unimpeded neutrophil proteases destroy the lung parenchyma. AAT is susceptible to oxidative damage resulting in an inability to inhibit its target proteases, neutrophil elastase, and cathepsin G. The major sites of oxidative modification on the AAT molecule are methionine residues 351 and 358. We have previously demonstrated that an engineered variant of AAT that resists oxidation by modifying both protein surface methionines (M351V and M358L) provides antiprotease protection, despite oxidative stress. In mice, intravenous delivery of the modified AAT(AVL) variant by AAV serotype 8, AAV8hAAT(AVL), primarily to the liver resulted in long-term expression of an AAT that resists oxidative inactivation. In this study, we evaluated the safety of intravenous administration of AAV8hAAT(AVL) in a dose-escalating, blinded, placebo-controlled toxicology study in wild-type mice. The study assessed organ histology and clinical pathology findings of mice, intravenously administered AAV8hAAT(AVL) at three doses (5.0 × 10<sup>11</sup>, 5.0 × 10<sup>12</sup>, and 5.0 × 10<sup>13</sup> genome copies [gc]/kg), compared to control mice injected intravenously with phosphate-buffered saline. As previously demonstrated, administration of AAV8hAAT(AVL) resulted in dose-dependent expression of high, potentially therapeutic, levels of serum human AAT protein that persist for at least 6 months. Antibodies against the AAV8 capsid were elicited as expected, but there was no antibody detected against the AAT(AVL) protein generated by the AAV8hAAT(AVL) vector. There was no morbidity or mortality observed in the study. The data demonstrate that intravenous administration of AAV8hAAT(AVL) is safe with no significant adverse effect attributed to AAV8hAAT(AVL) vector at any dose. This study demonstrates that AAV8hAAT(AVL) has a safety profile consistent with the requirements for proceeding to a clinical study.
Interfacial modifiers for enhanced stability and reduced degradation of Cu(In, Ga)Se<inf>2</inf> devices (2016)

Transparent conductive oxide (TCO) degradation is a known failure mode in thin-film photovoltaic (PV) devices through mechanisms such as resistivity increase and delamination. Here we apply thin interfacial modifiers to aluminum-doped zinc oxide (AZO) to mitigate damp heat induced degradation of electrical performance. Additionally, we demonstrate that these modifiers can be applied to the AZO front contact of a Cu(In, Ga)Se <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> device without significantly degrading the device performance, a promising step towards improving the lifetime performance.
Ambipolar Carrier Transport in Polycrystalline Pentacene Thin-Film Transistors (2006)

We have investigated the dependence of polycrystalline pentacene thin-film transistors (TFTs) characteristics on work function of source-drain contact metals. The pentacene TFTs using Mg, Al, Ag, and Au source-drain electrodes showed only p-type characteristics and the field-effect hole mobilities were strongly dependent on their work function. On the other hand, the pentacene TFTs using Ca source-drain electrodes showed typical ambipolar characteristics. The field-effect hole mobility of 4.5 × 10−4 cm2/Vs and field-effect electron mobility of 2.7 × 10−5 cm2/Vs were estimated from saturation currents. Appearance of an electron enhancement mode in pentacene TFTs was ascribed to the lowering of barrier for electron injection at source electrodes.
DNA element of Corynebacterium diphtheriae with properties of an insertion sequence and usefulness for epidemiological studies (1987)

The segment of DNA which is inserted within the tox gene of bacteriophage gamma and is responsible for its Tox- phenotype was found to be present and repeated approximately 30 times in the chromosome of Corynebacterium diphtheriae Belfanti 1030. Other C. diphtheriae strains contained a variable number of copies (1 to 25) of the same element. Sequence analysis showed that this repeated and interspersed DNA element was flanked by 9-base-pair direct repeats and that the 5' and 3' ends of the insertion contained sequences forming an imperfect inverted repeat. Therefore, the DNA segment here described has most of the typical structural features of a bacterial insertion sequence element. We show that different C. diphtheriae isolates derived from the same outbreak of diphtheria have an identical genomic distribution of this DNA element and that such DNA can be useful for epidemiological studies.
Dilative characteristics of Microvel and Vasculour-II aortic bifurcation grafts (1996)

Dilation is inherent to all knitted Dacron arterial prostheses. Insufficient clinical data regarding the usual dilative characteristics of specific grafts confound its significance and management. Alterations in size of all parts of knitted aortic bifurcation grafts (43 Microvel and 37 Vasculour-II) were evaluated by CT scanning in 80 patients; 76 scans were obtained in those with Microvel and 69 in those with Vasculour-II grafts. The mean dilation values were Microvel 54% +/- 16% SD at a mean follow-up of 21 months and Vasculour-II 48% +/- 21% SD with a mean follow-up of 73 months. Serial scans and a linear correlation study indicated that the rate of progressive dilation for both grafts was relatively low. The wide range of dilation values among patients with the same graft type, and even the same implantation time, operated upon by the same surgeon, suggests that multiple etiologic mechanisms are involved. Consequently, all patients must be evaluated individually, preferably with serial scans that evaluate all parts of the graft.
DO ALKANE THIOLS FORM STABLE MONOLAYER FILMS ON THE SURFACES OF HIGH-TEMPERATURE SUPERCONDUCTORS (HTSCS) (1995)

Recently there has been significant interest in the chemical modification of HTSC surfaces with molecule-based reagents. We will describe a preliminary survey of the surface coordination chemistry of YBa{sub 2}Cu{sub 3}O{sub 7-{gamma}} and other HTSC materials. In this survey, we have used a series of redox-active ligands containing alkyl amine, aryl amine, thiol, phosphine, amide, and alcohol functionalities. Evidence supporting the strong adsorption of molecules with alkyl amine, aryl amine and thiol functionalities will be reported. Resistivity measurements for the HTSCs and modified HTSCs show that chemical modification does not significantly lower T{sub c} for the superconductor. This work presents the first example of the direct chemical modification of the surface of a high-T{sub c} superconductor with a monolayer of a molecular reagent. A surprising result is that alkyl thiols do form stable, robust monolayers on a variety of HTSCs. Others have reported that under similar conditions alkyl thiols do not stably chemisorb onto HTSCs. However, alkyl amines are the superior reagent for the chemical modification of the Cu-rich HTSCs.
ChemInform Abstract: Group 4 Metallocene Olefin Hydrosilylation Catalysts. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Figure 3 from Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer (2023)

&lt;p&gt;PDF - 126K, Supplementary Figure S3. TNBC primary tumors and cell lines have elevated glutaminase (GAC) mRNA levels.&lt;/p&gt;
Titelbild: Alumina‐Supported Alpha‐Iron(III) Oxyhydroxide as a Recyclable Solid Catalyst for CO2 Photoreduction under Visible Light (Angew. Chem. 26/2022) (2022)

Für die Photoreduktion von CO2 zu Ameisensäure wurde ein Oxyhydroxid-Katalysator auf Fe-Basis entwickelt. Wie Kazuhiko Maeda et al. in ihrer Zuschrift berichten (DOI: 10.1002/ange.202204948), dient α-Eisen(III)-Oxyhydroxid auf einem Aluminiumoxidträger als wiederverwertbarer Katalysator für die CO2-Reduktionsreaktion, der mithilfe eines Ruthenium(II)-Photosensibilisators und eines Elektronendonors eine Selektivität von 80–0 % und eine effektive Quantenausbeute von 4.3 % bei 460 nm aufweist.
Chemoenzymatic Synthesis of Branched Polymers (2005)

Abstract Summary: The combination of enzymatic polymerization with ATRP for the synthesis of branched (block) copolymers was investigated. Heterotelechelic polycaprolactone macroinimer was synthesized in a one‐pot enzymatic procedure by using 2‐hydroxyethyl α ‐bromoisobutyrate as a bifunctional initiator. A polymerizable end group was introduced by subsequent in situ enzymatic acrylation with vinyl acrylate. Branched polymers were obtained by subsequent atom transfer radical polymerization (ATRP). Enzymatic synthesis of heterotelechelic macromonomers and subsequent self condensing vinyl polymerization by ATRP. image Enzymatic synthesis of heterotelechelic macromonomers and subsequent self condensing vinyl polymerization by ATRP.
Electrothermal evaluation of thick GaN epitaxial layers and AlGaN/GaN high-electron-mobility transistors on large-area engineered substrates (2017)

AlGaN/GaN high-electron-mobility transistor (HEMT) device layers were grown by metal organic chemical vapor deposition (MOCVD) on commercial engineered QST™ substrates to demonstrate a path to scalable, cost-effective foundry processing while supporting the thick epitaxial layers required for power HEMT structures. HEMT structures on 150 mm Si substrates were also evaluated. The HEMTs on engineered substrates exhibited material quality, DC performance, and forward blocking performance superior to those of the HEMT on Si. GaN device layers up to 15 µm were demonstrated with a wafer bow of 1 µm, representing the thickest films grown on 150-mm-diameter substrates with low bow to date.
Synthesis and reactivity of iron carbonyl complexes of β-silyl substituted α,β-unsaturated ketones (1995)

β-Silyl α,β-unsaturated ketones, R3SiCHCHC(O)Me (R3Si = Me3Si, ButMe2Si, PhMe2Si), react with [Fe2(CO)9] at 35 °C in diethyl ether to give tetracarbonyl[R3SiCHCHC(O)Me]iron(0) complexes and at 55 °C in toluene to give tricarbonyl[R3SiCHCHC(O)Me]iron(0) complexes. Tricarbonyl[Me3SiCHCHC(O)Me]iron(0) and tricarbonyl[ButMe2SiCHCHC(O)Me]iron(0) react with methyllithium under a nitrogen atmosphere to give hexane-2,5-dione and 3-(tert-butyldimethylsilyl)hexane-2,5-dione, respectively, and with methyllithium under a carbon monoxide atmosphere to give the vinylketene complexes tricarbonyl(3-methyl-5-trimethylsilyl-1-oxa-1,2,4-triene)iron(0) and tricarbonyl(5-tert-butyldimethylsilyl-3-methyl-1-oxapenta-1,2,4-triene)iron(0) respectively.
Thermal stability of metal Ohmic contacts in indium gallium zinc oxide transistors using a graphene barrier layer (2013)

The excellent impermeability of graphene was exploited to produce stable ohmic contact at the interface between Al metal and a semiconducting indium gallium zinc oxide (IGZO) layer after high-temperature annealing. Thin film transistors (TFTs) were fabricated with and without a graphene interlayer between the Al metal and the IGZO channel region. Metal contact at the interface prepared without a graphene interlayer showed serious instabilities in the IGZO TFT under thermal annealing; however, the insertion of a graphene interlayer between the IGZO channel and the Al metal offered good stability under repeated high-temperature annealing cycles and maintained ohmic contact.
Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases—Not Glycolipid Processing Enzymes (2016)

It has long been thought that iminosugar antiviral activity is a function of inhibition of endoplasmic reticulum-resident α-glucosidases, and on this basis, many iminosugars have been investigated as therapeutic agents for treatment of infection by a diverse spectrum of viruses, including dengue virus (DENV). However, iminosugars are glycomimetics possessing a nitrogen atom in place of the endocyclic oxygen atom, and the ubiquity of glycans in host metabolism suggests that multiple pathways can be targeted via iminosugar treatment. Successful treatment of patients with glycolipid processing defects using iminosugars highlights the clinical exploitation of iminosugar inhibition of enzymes other than ER α-glucosidases. Evidence correlating antiviral activity with successful inhibition of ER glucosidases together with the exclusion of alternative mechanisms of action of iminosugars in the context of DENV infection is limited. Celgosivir, a bicyclic iminosugar evaluated in phase Ib clinical trials as a therapeutic for the treatment of DENV infection, was confirmed to be antiviral in a lethal mouse model of antibody-enhanced DENV infection. In this study we provide the first evidence of the antiviral activity of celgosivir in primary human macrophages in vitro, in which it inhibits DENV secretion with an EC50 of 5 μM. We further demonstrate that monocyclic glucose-mimicking iminosugars inhibit isolated glycoprotein and glycolipid processing enzymes and that this inhibition also occurs in primary cells treated with these drugs. By comparison to bicyclic glucose-mimicking iminosugars which inhibit glycoprotein processing but do not inhibit glycolipid processing and galactose-mimicking iminosugars which do not inhibit glycoprotein processing but do inhibit glycolipid processing, we demonstrate that inhibition of endoplasmic reticulum-resident α-glucosidases, not glycolipid processing, is responsible for iminosugar antiviral activity against DENV. Our data suggest that inhibition of ER α-glucosidases prevents release of virus and is the primary antiviral mechanism of action of iminosugars against DENV.
23% faster program and 40% energy reduction of carbon nanotube non-volatile memory with over 1011 endurance (2014)

Carbon nanotube (CNT) non-volatile memory provides excellent cell characteristics of >10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sup> endurance, low power, fast <;5ns array program, and multi-level cell (MLC) potential. For the first time, optimal program methods are investigated considering speed, power and cell variability. Discrete cells are measured and a multiple-pulse reset scheme is proposed to reduce verify-reset time and a gate pulse verify-reset scheme further reduces array program energy by 40%.
Insights in the evolution of plant parasitism within the phylum Nematoda based on neutral and pathogenicity-related genes. (2013)

Plant parasitism has arisen at least four times independently within the phylum Nematoda. As a starting point to reconstruct evolution of parasitism within this ubiquitous and diverse group of animals, we use (nearly full length) small subunit ribosomal DNA (SSU rDNA) sequences (˜ 1,700 bp). Currently this phylum-wide framework encompasses over 2,500 taxa, and phylogenetic analysis reveals relationships within and among these four major lineages. Remarkably, SSU rDNA - known as a conserved gene - shows accelerated evolution in case of branches dominated by taxa with short life cycles, and/or animal or plant-parasitic life styles. One of the practical implications of this characteristic is the availability of unique DNA motifs within this gene that allows for relatively straightforward high-throughput detection of plant-parasitic nematode species in complex (= environmental) samples. Currently over 30 tests have been developed including most of the high-impact root knot, cyst and lesion nematode species attacking both Solanaceous and/or cereal crops. In parallel we investigated relationships within individual lineages of plant-parasitic nematodes with regard to non-neutral, plant pathogenicity-related genes, and by doing so we tried to find clues about the role of horizontal gene transfer in the transition from bacterivores (ancestral state) towards fungivores and facultative & obligate plant parasites (most derived state). Analysis of distribution and diversity of cell wall-degrading enzymes suggest for a very early acquisition, and subsequent diversification, and it would be highly interesting to look for related patterns in effector evolution.
Clutter map for a CW surveillance radar (2012)

A Radar target detection procedure for a surveillance Ku-band radar is considered in this paper. The radar system applies a Frequency Modulated Continuous Wave (FMCW) transmit signal with very short chirp duration. The specific waveform has been selected to measure with high resolution target range and radial velocity simultaneously and unambiguously even in multi target situations. The Ku-band radar has a transmit signal bandwidth of 3 MHz and a resulting range resolution of 50 m. Due to a long time on target of 500 ms a very high radial velocity resolution of 0.06 km/h is achieved. All echo signals from moving targets like cars and pedestrians shall be detected by this radar, while all clutter echo signals from fixed objects like buildings, wind turbines, forest and vegetation shall be suppressed. A high resolution clutter map, which suppresses all clutter signals reliably and in an adaptive way will be described in this paper.
Solvent Effects on the Ring Opening of Cyclopropanones to Oxyallyls: A Combined ab Initio and Monte Carlo Study (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolvent Effects on the Ring Opening of Cyclopropanones to Oxyallyls: A Combined ab Initio and Monte Carlo StudyDongchul Lim, David A. Hrovat, Weston Thatcher Borden, and William L. JorgensenCite this: J. Am. Chem. Soc. 1994, 116, 8, 3494–3499Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April 1994https://pubs.acs.org/doi/10.1021/ja00087a040https://doi.org/10.1021/ja00087a040research-articleACS PublicationsRequest reuse permissionsArticle Views230Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Correlations between Silica Chemistry and Structural Changes in Hydrothermally Treated Hexagonal Silica/Surfactant Composites Examined by in Situ X-ray Diffraction (2001)

In this paper, the effect of silica chemistry on hydrothermal restructuring of silica/surfactant composites is investigated. The materials were studied using real time X-ray diffraction to follow structural changes in p6mm hexagonal samples as they were hydrothermally treated in buffers ranging from pH 7 to pH 11. Changes in pore shape, repeat distance, and peak area were found to depend on the treatment conditions. Treatment at pH 11 caused expansion of the lattice, a small amount of pore shape restructuring, and a small increase in diffraction peak area. Treatment in a pH 7 hydrothermal solution, by contrast, resulted in contraction of the lattice, significant pore shape restructuring, and large increases in diffraction peak areas. These changes were correlated with 29Si MAS NMR, which was used to examine changes in framework polymerization, and with liquid 1H NMR, which was used to follow loss of surfactant from the composite. It was found that lattice expansion is facilitated by low framework polymerization and little or no surfactant loss while the opposite conditions were necessary for lattice contraction. The maximum amount of pore restructuring occurred under pH 9 conditions. At this pH, both silica condensation and silica hydrolysis have appreciable rates, suggesting that both processes are necessary for optimum restructuring. Finally, correlations between surfactant loss and changes in overall diffraction intensity indicated that these changes resulted primarily from increased electron density contrast in the material caused by loss of surfactant from the organic domains. The conclusions of this work help explain the molecular basis for the modifications that are commonly observed in X-ray diffraction patterns after hydrothermal treatment of periodic silica/surfactant composites.
Algorithm architecture co-design for ultra low-power image sensor (2012)

In a context of embedded video surveillance, stand alone leftbehind image sensors are used to detect events with high level of confidence, but also with a very low power consumption. Using a steady camera, motion detection algorithms based on background estimation to find regions in movement are simple to implement and computationally efficient. To reduce power consumption, the background is estimated using a down sampled image formed of macropixels. In order to extend the class of moving objects to be detected, we propose an original mixed mode architecture developed thanks to an algorithm architecture co-design methodology. This programmable architecture is composed of a vector of SIMD processors. A basic RISC architecture was optimized in order to implement motion detection algorithms with a dedicated set of 42 instructions. Definition of delta modulation as a calculation primitive has allowed to implement algorithms in a very compact way. Thereby, a 1920x1080@25fps CMOS image sensor performing integrated motion detection is proposed with a power estimation of 1.8 mW.