gebhart/patrepeval huggingface dataset:
A centromeric microsatellite probe on chromosome 3: LIB 9-95ca (D3S1338) (1993)

Journal Article A centromeric microsatellite probe on chromosome 3: LIB 9-95ca (D3S1338) Get access Laura Schmidt, Laura Schmidt * *To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Hua Li, Hua Li Search for other works by this author on: Oxford Academic PubMed Google Scholar Fuh-Mei C. Duh, Fuh-Mei C. Duh Search for other works by this author on: Oxford Academic PubMed Google Scholar Ming-Hui Wei, Ming-Hui Wei Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael I. Lerman, Michael I. Lerman 1Laboratory of Immunobiology, National Cancer Institute, Frederick Cancer Research and Development CenterFrederick, MD 21702, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Berton Zbar, Berton Zbar 1Laboratory of Immunobiology, National Cancer Institute, Frederick Cancer Research and Development CenterFrederick, MD 21702, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Kalman Tory Kalman Tory Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Molecular Genetics, Volume 2, Issue 3, March 1993, Page 335, https://doi.org/10.1093/hmg/2.3.335-a Published: 01 March 1993
High-Power-Density InAlGaN/GaN-HEMT Technology for W-Band Amplifier (2016)

We demonstrated an excellent output power (Pout) density performance using a novel InAlGaN/GaN-HEMT with an 80-nm gate for a high-power W-band amplifier. The developed HEMT showed basic reliability for commercial products. A unique double-layer silicon nitride (SiN) passivation film with oxidation resistance was adopted to suppress current collapse. The developed discrete InAlGaN/GaN-HEMT achieved a Pout density of 3.0 W/mm at 96 GHz, and the Pout density of MMIC reached 3.6W/mm at 86 GHz. We proved excellent potential of developed InAlGaN/GaN-HEMT using our unique device technologies. Furthermore, we suggested the physical advantage of the InAlGaN/GaN-HEMT structure using device simulator.
Supplementary Figures 1-2 from Genetic Instability Caused by Loss of MutS Homologue 3 in Human Colorectal Cancer (2023)

Supplementary Figures 1-2 from Genetic Instability Caused by Loss of MutS Homologue 3 in Human Colorectal Cancer
Unexpected Coordination Chemistry of Bisphenanthroline Complexes within Hybrid Materials:  A Mild Way to Eu2+ Containing Materials with Bright Yellow Luminescence (2007)

A hybrid organic−inorganic material containing bisphenanthroline units forming tetrahedral cavities was prepared. We show that these cavities not only allow the incorporation of Cu2+ and Eu3+ ions but also induce the reduction of these ions in Cu+ and Eu2+, respectively. The Eu2+ containing material shows an extremely bright yellow luminescence and might be therefore a candidate for future applications.
Effect of Antibody to Capsular Polysaccharide on Eosinophilic Pneumonia in Murine Infection withCryptococcus neoformans (1998)

The effect of the murine IgG1 monoclonal antibody (MAb) 2H1, which binds to Cryptococcus neoformans glucuronoxylomannan (GXM), on pulmonary infection in immunocompetent C57Bl/6 mice was examined. C57Bl/6 mice develop eosinophilic pneumonia in response to pulmonary cryptococcal infection. Survival, organ fungus burden, serum anticapsular antibody levels, and histopathology by light and electron microscopy were studied. MAb administration prior to infection prolonged survival without reducing the number of yeast in the lung or extrapulmonary sites. Compared with uninfected mice, occasional control and MAb-treated mice produced more IgM antibody to GXM or low levels of GXM-binding IgG1, IgG2b, or IgG3 antibodies. MAb-treated mice had fewer granules per eosinophil, indicating alteration in eosinophil physiology or degranulation (or both). Our results provide additional evidence that antibody administration can produce quantitative and qualitative changes in the inflammatory response to a pathogen.
Packet loss effects on MPEG video sent over the public Internet (1998)

Article Free Access Share on Packet loss effects on MPEG video sent over the public Internet Authors: Jill M. Boyce Bell Laboratories, Lucent Technologies, 101 Crawfords Corner Rd, Holmel, NJ Bell Laboratories, Lucent Technologies, 101 Crawfords Corner Rd, Holmel, NJView Profile , Robert D. Gaglianello Bell Laboratories, Lucent Technologies, 101 Crawfords Corner Rd, Holmel, NJ Bell Laboratories, Lucent Technologies, 101 Crawfords Corner Rd, Holmel, NJView Profile Authors Info & Claims MULTIMEDIA '98: Proceedings of the sixth ACM international conference on MultimediaSeptember 1998 Pages 181–190https://doi.org/10.1145/290747.290770Online:01 September 1998Publication History 122citation1,502DownloadsMetricsTotal Citations122Total Downloads1,502Last 12 Months31Last 6 weeks6 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Abstract 523: Three-dimensional hyaluronic acid-based hydrogel systems for studies of cancer invasion (2010)

Abstract Currently available invasion assays for study of cancer metastasis have limitations that led us to develop a novel system that provides a more flexible, quantifiable, and physiologically relevant method to study cancer cell invasion. The three-dimensional (3D) hyaluronic acid (HA) hydrogel invasion assay then was used to study HA receptor signaling as it occurs during prostate cancer metastasis to bone marrow. Our invasion assay uses the HA hydrogel which reflects the prevalence of HA in the bone marrow and its key role in the promotion of cancer cell motility and tissue invasion. The HA hydrogel spontaneously crosslinks via interaction of aldehyde and hydrazide groups, allowing for direct encapsulation of cells within the gel. This cell/gel construct is plated in a 12 mm tissue culture insert for construction of the invasion assay. The cells are situated on a single plane so that individual cell movement from that plane can be tracked. We show that our 3D HA hydrogel invasion assay allows for cell migration/invasion in response to a chemoattractant, fetal bovine serum (FBS), and that this movement is easily quantified using confocal microscopy techniques over a distance of up to 1 mm. The ability of cancer cells to invade the HA hydrogel depends on their expression of HA receptors and hyaluronidases; more highly invasive cell lines express HA receptors and hyaluronidases at higher levels. We will show that culture in the HA hydrogel triggers differential expression and/or compartmental translocation of HA receptor proteins and downstream effectors, all of which contribute to motility and metastasis. Ongoing work examines the role that a specific HA receptor, RHAMM, plays in prostate cancer metastasis, specifically how it activates Rho GTPases that increase cell motility. We will show how these physiologically relevant 3-D HA hydrogel invasion assays can be used to study such pathways. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 523.
Reactively evaporated films of copper molybdenum sulfide (1978)

Films of superconducting Chevrel-phase copper molybdenum sulfide CuxMo6S8 were deposited on sapphire substrates by reactive evaporation using H2S as the reacting gas. Two superconducting temperatures (10.0 K and 5.0 K) of the films were found, corresponding to two different phases with different copper concentrations. All films were superconducting above 4.2 K and contained Chevrel-phase compound as well as free molybdenum. The critical current was measured as a function of applied field. One sample was found to deviate from the scaling law found for co-evaporated or sputtered samples, which possibly indicates a different pinning mechanism or inhomogeneity of the sample.
Unorthodox myogenesis: possible developmental significance and implications for tissue histogenesis and regeneration. (1997)

During the last few years several reports have described the occurrence of skeletal myogenesis in cells derived from embryonic, fetal and perinatal tissues that usually do not contribute to skeletal muscle in the adult vertebrate body. After a brief description of current ideas on myogenic determination in higher vertebrates, three examples of this unorthodox myogenesis will be described: 1) the occurrence of myogenesis in chick epiblast cells, cultured in isolation in serum-free medium; 2) the presence of cells endowed with myogenic potential in the embryonic mouse neural tube; and 3) the occurrence of spontaneous or induced myogenesis in mesenchymal cells during fetal and postnatal life. A possible embryological basis for unorthodox myogenesis, in relation to gastrulation and morphogenetic fields, is then presented. It is also proposed that unorthodox myogenesis may represent a compensatory mechanism for higher vertebrates that have lost much of the regeneration potential of lower vertebrates.
Laser-Flash Photolysis in High-Speed Photopolymer Coating Layers Containing Carbonylbiscoumarin Dyes and 2,2′-Bis(2-chlorophenyl)-4,4′,5,5′-tetraphenyl-1,1′-bi-1H-imidazole (1997)

Abstract The sensitization mechanisms of ketocoumarin dyes with a radical-generating reagent (10,10′-carbonylbis[1,1,7,7-tetramethyl-2,3,6,7-tetrahydro-1H,5H,11H-[1]benzopyrano[6,7,8-ij]quinolizin-11-one] (KCD-J), 3,3′-carbonyldis[7-(diethylamino)-2H-1-benzopyran-2-one] (KCD-DA)) with 2,2′-bis(2-chlorophenyl)-4,4′,5,5′-tetraphenyl-1,1′-bi-1H-imidazole (BI) in a poly(methyl methacrylate) (PMMA) film have been investigated by laser-flash photolysis using a total-reflection cell. The triplet decay time of the dyes in a PMMA film was quenched by BI with a kqs of 1.3 and 0.60 × 105 mol dm−3 s−1 for KCD-J and KCD-DA. The fluorescence and initial absorption for KCD-DA were not quenched by BI in a PMMA film. The fluorescence was quenched at a quenching distance of 10.0 Å, and the initial triplet absorption was not quenched for KCD-J in a PMMA film. These results show that a nonstatic sensitization from the triplet to BI is the predominant process in a photoinitiation system containing KCD-DA, and that both static sensitization from the singlet excited state to BI and nonstatic sensitization from the triplet to BI exist in a photoinitiation system containing KCD-J.
Structure of the rapeseed 1.7 S storage protein, napin, and its precursor. (1986)

Napin (1.7 S protein) is a basic, low molecular weight storage protein synthesized in rapeseed (Brassica napus) embryos during seed development. Napin is composed of two polypeptide chains with molecular weights of 9000 and 4000 that are held together by disulfide bonds. Comparison of the deduced amino acid sequence of a napin cDNA clone with that of napin peptide fragments established that napin is initially synthesized as a precursor of 178 residues. This polypeptide is subsequently processed through several proteolytic events, which ultimately generate the two mature napin chains, of 86 and 29 residues, respectively. Protein biosynthesis in vitro showed that the initial translation product (Mr 20,000) contains a signal sequence which is removed during transfer of the protein into the endoplasmic reticulum. Two additional peptides, of 22 and 19 residues, as well as the COOH-terminal residue, are also removed during maturation of napin, as deduced from the sequence comparison. Comparisons of the napin sequence with other known protein sequences established that there is a significant homology between napin and two other small seed proteins, the castor bean storage protein and a trypsin inhibitor from barley.
Dissection of Double-Stranded RNA Binding Protein B2 from Betanodavirus (2007)

Betanodaviruses are small RNA viruses that infect teleost fish and pose a considerable threat to marine aquaculture production. These viruses possess a small protein, termed B2, which binds to and protects double-stranded RNA. This prevents cleavage of virus-derived double-stranded RNAs (dsRNAs) by Dicer and subsequent production of small interfering RNA (siRNA), which would otherwise induce an RNA-silencing response against the virus. In this work, we have performed charged-to-alanine scanning mutagenesis of the B2 protein in order to identify residues required for dsRNA binding and protection. While the majority of the 19 mutated B2 residues were required for maximal dsRNA binding and protection in vitro, residues R53 and R60 were essential for both activities. Subsequent experiments in fish cells confirmed these findings by showing that mutations in these residues abolished accumulation of both the RNA1 and RNA2 components of the viral genome, in addition to preventing any significant induction of the host interferon gene, Mx. Moreover, an obvious positive correlation was found between dsRNA binding and protection in vitro and RNA1, RNA2, and Mx accumulation in fish cells, further validating the importance of the selected amino acid residues. The same trend was also demonstrated using an RNA silencing system in HeLa cells, with residues R53 and R60 being essential for suppression of RNA silencing. Importantly, we found that siRNA-mediated knockdown of Dicer dramatically enhanced the accumulation of a B2 mutant. In addition, we found that B2 is able to induce apoptosis in fish cells but that this was not the result of dsRNA binding.
Design of an oblique camera based on a field-dependent parameter (2019)

In this paper, a new parameter, field focal length (FFL), is introduced to characterize the optical properties for each field of an optical system. A freeform three-mirror off-axis reflective system, working as an oblique camera, is found to have various FFLs across the field angle of 30°. With the help of FFL, the ground resolution (GR) of this camera is analyzed under two working modes. One of the two working modes has more uniform GR when the field with larger FFL value aims at the object far away from the camera. By using FFL to control the GR, an oblique camera system is designed that has a constant GR within 99.41% over the field of view.
A Self-Consistent, Semiclassical Electrothermal Modeling Framework for Mott Devices (2018)

Mott materials have been investigated since late 1950s for their remarkably abrupt insulator to metal transition (IMT) in response to changes in temperature, strain, or electrical stimulus. Interest in these materials has been revived by recent demonstration of nanosecond-scale switching along with reproducible and fully reversible transitions in VO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> -based thin film devices. These phenomena make VO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> -based Mott insulator devices technologically relevant for various applications, such as memory selectors, logic switches, and building blocks for neuromorphic computing. Several groups have provisionally attributed the IMT switching to Joule heating. However, an electrothermal device simulation framework that self-consistently reproduces IMT phase transition, and in addition, explaining a variety of electrical/optical phenomena associated with IMT is still lacking. In this paper, we develop a self-consistent electrothermal device simulation framework which captures these key experimental attributes of IMT using VO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> as a model material. This framework will enable predictive modeling as well as provide insight on switching mechanisms and design of novel Mott insulator devices.
Posterior probability of linkage analysis of autism dataset identifies linkage to chromosome 16 (2008)

We find strengthened evidence for linkage of autism to chromosomes 1q, 13p, 16q, and Xq, and diminished evidence for linkage to 7q and 13q. The verity of these findings will be tested by continuing to update our PPL analyses with data from additional autism datasets.
Cellulose-Based Nanofibril Composite Materials as a New Approach to Fight Bacterial Infections (2021)

Antibiotic resistant microorganisms have become an enormous global challenge, and are predicted to cause hundreds of millions of deaths. Therefore, the search for novel/alternative antimicrobial agents is a grand global challenge. Cellulose is an abundant biopolymer with the advantages of low cost, biodegradability, and biocompatibility. With the recent growth of nanotechnology and nanomedicine, numerous researchers have investigated nanofibril cellulose to try to develop an anti-bacterial biomaterial. However, nanofibril cellulose has no inherent antibacterial activity, and therefore cannot be used on its own. To empower cellulose with anti-bacterial properties, new efficient nanomaterials have been designed based on cellulose-based nanofibrils as potential wound dressings, food packaging, and for other antibacterial applications. In this review we summarize reports concerning the therapeutic potential of cellulose-based nanofibrils against various bacterial infections.
Female Sex and Gender in Lung/Sleep Health and Disease: Increased Understanding of Basic Biological, Pathophysiological, and Behavioral Mechanisms Leading to Better Health for Female Patients with Lung Disease (2018)

Female sex/gender is an undercharacterized variable in studies related to lung development and disease. Notwithstanding, many aspects of lung and sleep biology and pathobiology are impacted by female sex and female reproductive transitions. These may manifest as differential gene expression or peculiar organ development. Some conditions are more prevalent in women, such as asthma and insomnia, or, in the case of lymphangioleiomyomatosis, are seen almost exclusively in women. In other diseases, presentation differs, such as the higher frequency of exacerbations experienced by women with chronic obstructive pulmonary disease or greater cardiac morbidity among women with sleep-disordered breathing. Recent advances in -omics and behavioral science provide an opportunity to specifically address sex-based differences and explore research needs and opportunities that will elucidate biochemical pathways, thus enabling more targeted/personalized therapies. To explore the status of and opportunities for research in this area, the NHLBI, in partnership with the NIH Office of Research on Women's Health and the Office of Rare Diseases Research, convened a workshop of investigators in Bethesda, Maryland on September 18 and 19, 2017. At the workshop, the participants reviewed the current understanding of the biological, behavioral, and clinical implications of female sex and gender on lung and sleep health and disease, and formulated recommendations that address research gaps, with a view to achieving better health outcomes through more precise management of female patients with nonneoplastic lung disease. This report summarizes those discussions.
The effect of membrane potential on the mammalian sodium‐potassium pump reconstituted into phospholipid vesicles. (1987)

1. We have studied effects of electrical diffusion potentials on active Na+-K+ exchange in phospholipid vesicles reconstituted with pig kidney Na+, K+-ATPase. 2. Diffusion potentials, negative inside, were established using outwardly directed K+ gradients plus valinomycin or Li+ gradients plus a Li+ ionophore, AS701. Measurement of fluorescence changes of the carbocyanine dye DiS-C3-(5) showed that the ionophores generated potentials of the expected orientation and of sufficient stability for their effects on active transport to be assessed. Measurement of rates of passive 22Na+ fluxes, over a wide range of diffusion potentials, were consistent with the quantitative predictions of the constant-field flux equation. This result demonstrates that values of diffusion potentials calculated from the Nernst or constant-field equation are accurate. 3. In some conditions, the inside-negative potential (-130 to -180 mV) accelerated the rate of ATP-dependent Na+-K+ exchange on inside-out-oriented pumps, compared to 'control' without the ionophores. Reduction in the size of the diffusion potentials by addition to the medium of Li+ with AS701 or Cs+ with the valinomycin progressively annulled the acceleratory effects, consistent with these being true effects of a change in membrane potentials. 4. At saturating cytoplasmic Na+ and ATP concentrations, the diffusion potential accelerated ATP-dependent Na+-K+ exchange by up to about 30% compared to control but this effect disappeared at rate-limiting ATP concentrations (approximately 1 microM). 5. Using prior knowledge of rate-limiting steps, we interpret this finding to mean that the conformational transition E2(2K)----E12K associated with transport of two K+ ions is voltage insensitive while E1P(3Na)----E2P3Na associated with transport of three Na+ ions is voltage sensitive. The simplest explanation is that the net charge in the transport domain of the protein when no ions, 2K+ or 3Na+ are bound is -2, 0 and +1 respectively. 6. The accelerating effect of the negative-inside diffusion potential on Na+-K+ exchange is greater at limitingly low cytoplasmic Na+ concentrations than at saturating cytoplasmic Na+ concentrations. Cytoplasmic Na+ activation curves show that the diffusion potential increases the apparent cytoplasmic Na+ affinity and reduces the sigmoidicity of cytoplasmic Na+ activation. 7. A kinetic analysis reveals that this effect on apparent affinity is due to an increase in intrinsic Na+ binding and occurs in addition to the effect on a transport rate constant.(ABSTRACT TRUNCATED AT 400 WORDS)
SIRT3 and cancer: Tumor promoter or suppressor? (2011)

Sirtuins (SIRT1-7), the mammalian homologues of the Sir2 gene in yeast, have emerging roles in age-related diseases, such as cardiac hypertrophy, diabetes, obesity, and cancer. However, the role of several sirtuin family members, including SIRT1 and SIRT3, in cancer has been controversial. The aim of this review is to explore and discuss the seemingly dichotomous role of SIRT3 in cancer biology with particular emphasis on its potential role as a tumor promoter and tumor suppressor. This review will also discuss the potential role of SIRT3 as a novel therapeutic target to treat cancer.
Modeling quality of service vs. Peak Reduction trade-offs in A/C-based Demand-Side Management (2011)

A large number of A/C units potentially represents a substantial flexible load susceptible to be leveraged for Demand-Side Management (DSM) purposes. However, in such a scenario, a drop in quality of service (QoS), i.e. an uncomfortable increase in temperature, is to be expected as some cooling-down is delayed to achieve peak reduction. We present the results of a simulation study designed to test a decentralised control framework based on probabilistic activation of individual A/C units and reactive pricing [1]. Performance is evaluated and discussed, primarily in terms of the trade-off between QoS and DSM efficiency.