gebhart/patrepeval huggingface dataset:
Synthesis of new bis‐pyrazole linked hydrazides and their in vitro evaluation as antimicrobial and anti‐biofilm agents: A mechanistic role on ergosterol biosynthesis inhibition in Candida albicans (2019)

Literature reports suggest that pyrazoles and hydrazides are potential antimicrobial pharmocophores. Considering this fact, a series of nineteen conjugates containing hybrids of bis-pyrazole scaffolds joined through a hydrazide linker were synthesized and further evaluated for their antimicrobial activity against a panel of Gram-positive and Gram-negative bacteria along with Candida albicansMTCC 3017 strain. Although the derivatives exhibited good antibacterial activity, some of the derivatives (13d, 13j, 13l, 13p, and 13r) showed excellent anti-Candida activity with MICs values of 3.9 μg/ml, which was equipotent to that of the standard Miconazole (3.9 μg/ml), which has inspired us to further explore their anti-Candida activity. The same compounds were also tested for anti-biofilm studies against various Candida strains and among them, compounds 13l and 13r efficiently inhibited the formation of fungal biofilms. Field emission scanning electron micrographs revealed that one of the promising compound 13r showed cell damage and in turn cell death of the Candida strain. These potential conjugates (13l and 13r) also demonstrated promising ergosterol biosynthesis inhibition against some of the strains C. albicans, which were further validated through molecular docking studies. In silico computational studies were carried out to predict the binding modes and pharmacokinetic parameters of these conjugates.
Ultra-high reflectivity photonic crystal reflectors for cavity optomechanics (2021)

We demonstrate a silicon nitride membrane incorporating two-dimensional photonic crystal structure. A Fabry-Perot (FP) cavity with a finesse as high as 26500 is constructed using the photonic crystal mirror, corresponding a photonic crystal reflectivity of 99.99%.
Rapid restriction fragment analysis for screening four point mutations of the Low-density lipoprotein receptor gene in French Canadians (1995)

Familial hypercholesterolemia (FH) has an estimated frequency of 1:154 among French Canadians in Northeastern Quebec, compared with 1:500 in most other populations. FH is caused by numerous mutations of the low-density lipoprotein (LDL) receptor gene, but only six well-characterized mutations are known to cause FH in French Canadians. High prevalence of the phenotype, along with a limited number of mutations in this population, provides a unique opportunity to study genotype-phenotype variation. Since the current methods for detection of point mutations in this population use complicated approaches, we report polymerase chain reaction (PCR)-based restriction fragment analysis to detect all four point mutations. This approach provides a rapid diagnosis and is suitable to screen large number of samples for studies in genetic epidemiology; it should be useful in identifying FH in other populations bearing the same mutations.
TERPHENYL LIGANDS AND COMPLEXES (2018)

This chapter is concerned with a range of ligands that feature sterically encumbering terphenyl substituents. It discusses the syntheses of the bis(terphenyl) main group derivatives M(C6H3- 2,6-Mes2)2 and M(C6H3-2,6-Dipp2)2 (M = Ge, Sn, or Pb). The chapter describes synthesis of both H2NC6H3- 2,6-Mes2 and H2NC6H3-2,6-Trip2. It provides the synthesis of H2NC6H3-2,6-Dipp2. The chapter also describes how the amines H2NC6H3-2,6-Mes2 and H2NC6H3-2,6-Dipp2 are converted to the corresponding formamides by reaction with formic acid or formic acetic anhydride. Further reaction of these derivatives with phosphorus oxychloride, diisopropylamine, and sodium carbonate affords the terphenyl isocyanides CNC6H3-2,6-Mes2 and CNC6H3-2,6-Dipp2. These π-acid isocyanide ligands provide access to their transition metal complexes with unusual, nonstandard coordination numbers, oxidation states, and stabilities. Other terphenyl ligands described in the chapter include the terphenyls HOC6H3-2,6-Mes2 and HOC6H3-2,6-Dipp2.
Non-chemical control of carrot rust fly in Finland (1988)

Ab initio potential energy curves of CO are calculated to address a number of problems remaining in the interpretation of the experimental VUV absorption spectra. The calculations are of the type SCF MRSD-CI. We employed the aug-cc-pVQZ basis set for both carbon and oxygen, augmented with twelve diffuse functions, of s-, p-, and d-type, located on both atomic centers. We focus on the energy region 85,000 cm(-1) < E < 110,000 cm(-1) characterized by strong interactions between Rydberg and valence states. In this work we deal specifically with the (1)Sigma(+), (1)Pi, and (3)Pi states lying in this region. Some of the relevant findings are as follows: The minimum of the C'(1)Sigma(+) valence state is found 1920 cm(-1) above the value inferred from an extrapolation of experimental data. A new (1)Pi valence state, labeled E', is found to perturb strongly the (X(2)Sigma(+))3ppi E(1)Pi Rydberg state. The electrostatic perturbation of the (X(2)Sigma(+))3ppi c(3)Pi Rydberg state by the k(3)Pi valence state is confirmed. The energy position of the (A(2)Pi)3ssigma (3)Pi state, the triplet companion of the W(1)Pi Rydberg state, is predicted.
An Open Catalog of Hand Gestures from Sci-Fi Movies (2015)

In Science Fiction (Sci-Fi) movies, filmmakers try to anticipate trends and new forms of interaction. Metaphors are created allowing their characters to interact with devices and futuristic environments. These devices and metaphors may be target of research considering they have proven to be useful before, as for example the Star Trek communicator (1966) similarity to the Motorola StarTAC phone (1996). Moreover, the impact of the new interfaces on the audience may indicate their expectations regarding future gesture interactions. Thus, the goal of this work is to collect and expose a compilation of hand interactions in Sci-Fi movies, providing an open catalog to researchers as resource to future discussions. The data visualization and analysis is facilitated through an open-source web application. Additionally, we classify the collected data according to a series of established criteria and our own knowledge.
Convenient Microtiter assay for von Willebrand’s Factor (1977)

A simple method for measurement of von Willebrand’s factor (VWF) suitable for the clinical coagulation laboratory would substantially aid in the differential diagnosis of bleeding disorders We have developed a simple macroscopic titration assay of plasma VWF using the Ristocetin induced aggregation of washed, fixed normal platelets. The assay employs arithmetic dilutions of test plasma in buffer, Ristocetin and washed, fixed platelets in a final volume of 0.4 ml per well. After 20 minutes’ agitation on a rotary shaker at room temperature, an endpoint of visible aggregation can be determined. Fifty normal plasmas tested had a mean titer of 1/500 (range 1/240 to 1/853) whereas 8 plasmas from patients with known von Willebrand’s disease (VWD) had a mean titer of 1/21 (range 1/10 to 1/186). Deviation from the normal range correlated with the severity of the VWD. Reproducibility of results was within ±10%. Platelets washed before fixation with paraformaldehyde (method modified from Allain et al, J. Lab. Clin. Med. 85:318, 1975) appear almost twice as sensitive to VWF in this assay as those fixed in platelet rich plasma and washed subsequently. Fresh and frozen plasmas give equivalent results, permitting storage of specimens. This microtiter assay thus offers a sensitive measure of VWF Ristocetin cofactor activity, utilizes stable and standardizable reagents, requires only small amounts of patient plasma (or other biological materials) and permits rapid testing of different specimens simultaneously.
Foundations of Secure Scaling (Dagstuhl Seminar 16342) (2017)

This report documents the program and the outcomes of Dagstuhl Seminar 16342 "Foundations of Secure Scaling". This seminar hosted researchers in secure electronic system design, spanning all abstraction levels from cryptographic engineering over chip design to system integration. We recognize that scaling is a fundamental force present at every abstraction level in electronic system design. While scaling is generally thought of as beneficial to the resulting implementations, this does not hold for secure electronic design. Indeed, the relations between scaling and the resulting security are poorly understood. This seminar facilitated the discussion between security experts at different abstraction levels in order to uncover the links between scaling and the resulting security.
Feasibility of Detecting Bioorganic Compounds in Enceladus Plumes with the Enceladus Organic Analyzer (2017)

Enceladus presents an excellent opportunity to detect organic molecules that are relevant for habitability as well as bioorganic molecules that provide evidence for extraterrestrial life because Enceladus' plume is composed of material from the subsurface ocean that has a high habitability potential and significant organic content. A primary challenge is to send instruments to Enceladus that can efficiently sample organic molecules in the plume and analyze for the most relevant molecules with the necessary detection limits. To this end, we present the scientific feasibility and engineering design of the Enceladus Organic Analyzer (EOA) that uses a microfluidic capillary electrophoresis system to provide sensitive detection of a wide range of relevant organic molecules, including amines, amino acids, and carboxylic acids, with ppm plume-detection limits (100 pM limits of detection). Importantly, the design of a capture plate that effectively gathers plume ice particles at encounter velocities from 200 m/s to 5 km/s is described, and the ice particle impact is modeled to demonstrate that material will be efficiently captured without organic decomposition. While the EOA can also operate on a landed mission, the relative technical ease of a fly-by mission to Enceladus, the possibility to nondestructively capture pristine samples from deep within the Enceladus ocean, plus the high sensitivity of the EOA instrument for molecules of bioorganic relevance for life detection argue for the inclusion of EOA on Enceladus missions. Key Words: Lab-on-a-chip-Organic biomarkers-Life detection-Planetary exploration. Astrobiology 17, 902-912.
Telomeres and Telomerase: Implications for Cancer and Aging (2001)

Maintenance of telomere stability is required for cells to escape from replicative senescence and proliferate indefinitely. Telomere length is maintained by a balance between processes that lengthen telomeres (telomerase) and processes that shorten telomeres (the end-replication problem). Telomerase is a cellular ribonucleoprotein reverse transcriptase which stabilizes telomere length by adding hexameric (TTAGGG) repeats to the telomeric ends of the chromosomes, thus compensating for the continued erosion of telomeres. Introduction of the telomerase catalytic protein component into normal telomerase-negative human cells results in restoration of telomerase activity and extension of cellular life span. Human cells with introduced telomerase maintain a normal chromosome complement and continue to grow in a normal manner. Telomerase-induced manipulations of telomere length may thus be important not only for cell and tissue engineering but also for dissecting the molecular mechanisms underlying inherited genetic diseases, as well as defining the genetic pathways leading to cancer. Because almost all human tumors express telomerase activity, inhibition of telomerase may result in gradual erosion of telomeres and eventual cessation of cell proliferation or induction of apoptosis. Thus telomerase may also be a promising target for cancer therapy.
Current sharing for multichannel solar power system with maximum power point tracking (2005)

In an effort to maximize its reliability and life expectancy, an output current-sharing scheme is applied to a modular solar-powered DC power system. The proposed scheme fits into the digital controller already in place for use in maximum power point tracking (MPPT), and requires minimal hardware modifications. The digital nature of the scheme provides enough flexibility to accommodate the transition of channels with limited power resources into MPPT mode. A controller area network is setup to form a noise-immune digital current-sharing bus that naturally allows the system to overcome different challenges introduced by the existing analog current-sharing bus schemes. Theoretical analysis predicts the preservation of closed-loop system performance for scalable power systems. A four-channel prototype was constructed and tested to validate the control scheme under different insolation levels and loading conditions.
Power system transient stability enhancement by STATCOM with nonlinear control system (2003)

A nonlinear control approach is applied to static synchronous compensator (STATCOM), which is one of the FACTS devices. Here, the nonlinear controller is designed locally based on mathematical models of one of the generators, STATCOM and transmission lines in a multi-machine system. The influence of the proposed controller, which controls the terminal voltage of STATCOM, on the power system stability is tested by digital dynamic simulations. As a result of the simulation, it has been made clear that the STATCOM can improve the transient stability in the 3-machine loop system. In the case of the IEEJ West 10-machine system, the effectiveness is also discussed.
Replication data for: A Procurement Auction for Toxic Assets with Asymmetric Information (2013)

The proposed 2008 TARP auction was intended to remove "toxic" assets from portfolios of financially stressed banks. The Treasury selected a design whereby bids to sell different securities would be normalized by "reference prices" that reflect relative value estimates. We conduct a series of experiments indicating that a simple Reference Price Auction can be an effective mechanism for avoiding serious effects of adverse selection and strategic bid manipulation, even with inaccurate reference prices. Beyond the TARP auction, our results are relevant to various multi-object auctions with value heterogeneity.
Evidence of intermolecular species formation with electrical aging in anthracene-based blue organic light-emitting devices (2010)

Electrical aging mechanism in blue emitting organic light-emitting devices (OLEDs) based on 9,10-bis (2-naphthyl)-2-t-butyl anthracene (TBADN) fluorescent emitter is investigated using a number of techniques, including delayed electroluminescence measurements. The studies reveal that electrical aging is associated with an increasing concentration of an intermolecular species with a weak characteristic luminescence at around 535 nm. This species is capable of charge trapping, and thus plays a role as an electron-hole recombination center with prolonged electrical driving. Weak green luminescence from this species leads to an increased green/blue emission ratio, and causes the color purity loss in aged devices. The results also suggest that this species is also efficient in dissipating excitation energy nonradiatively, hence is capable of quenching TBADN singlet excitons, contributing to the observed efficiency loss with electrical aging.
Droop control for bi-directional DC-DC converters used in multi-level virtual conductors (2015)

This paper proposes droop control for Multi-Level Virtual Conductor (MLVC). This control method aims at overcoming the problem that circulating current flows when MLVC constitutes a mesh connection. Generally, the voltage difference between the terminals of any conductor is zero volts. However, MLVC can keep the voltage difference between the converter terminals constant at a certain value. In this way, the converter performs like a conductor but, unlike the normal conductor, it has a voltage difference between its terminals. Circulating current flows when MLVC constitutes a mesh configuration. This research proposes an application of a droop control to bi-directional DC-DC converter to overcome such circulating current. The proposed control method is investigated both analytically and experimentally.
The Nucleotide-Binding Domain, Leucine-Rich Repeat Protein 3 Inflammasome/IL-1 Receptor I Axis Mediates Innate, but Not Adaptive, Immune Responses after Exposure to Particulate Matter under 10 μm (2014)

Exposure to particulate matter (PM), a major component of air pollution, contributes to increased morbidity and mortality worldwide. Inhaled PM induces innate immune responses by airway epithelial cells that may lead to the exacerbation or de novo development of airway disease. We have previously shown that 10-μm PM (PM10) activates the nucleotide-binding domain, leucine-rich repeat protein (NLRP) 3 inflammasome in human airway epithelial cells. Our objective was to determine the innate and adaptive immune responses mediated by the airway epithelium NLRP3 inflammasome in response to PM10 exposure. Using in vitro cultures of human airway epithelial cells and in vivo studies with wild-type and Nlrp3(-/-) mice, we investigated the downstream consequences of PM10-induced NLPR3 inflammasome activation on cytokine production, cellular inflammation, dendritic cell activation, and PM10-facilitated allergic sensitization. PM10 activates an NLRP3 inflammasome/IL-1 receptor I (IL-1RI) axis in airway epithelial cells, resulting in IL-1β, CC chemokine ligand-20, and granulocyte/macrophage colony-stimulating factor production, which is associated with dendritic cell activation and lung neutrophilia. Despite these profound innate immune responses in the airway epithelium, the NLRP3 inflammasome/IL-1RI axis is dispensable for PM10-facilitated allergic sensitization. We demonstrate the importance of the lung NLRP3 inflammasome in mediating PM10 exposure-associated innate, but not adaptive, immune responses. Our study highlights a mechanism by which PM10 exposure can contribute to the exacerbation of airway disease, but not PM10-facilitated allergic sensitization.
Social networks over wireless networks (2012)

We consider the formation, operation and maintenance of dynamic social networks (among human users) supported by technological communication networks such as wireless networks, or hybrid wireline-wireless networks. The technological (physical) networks of interest display dynamic behavior in several dimensions, including variable connectivity, variable congestion, variable link characteristics. As broad-band wireless devices and networks are becoming ubiquitous these human-machine systems, that combine the social aspects and behavioral activities of humans with the technological characteristics of the underlying physical networks, provide several important challenges in efforts to model them, evaluate their performance and dynamically control them so certain performance requirements are met. These include combinations of performance, trust, privacy, energy efficiency. In this paper we develop novel models for these complex human-machine systems that incorporate social network behavioral models and wireless network models that are inspired from statistical physics (hyperbolic graphs). We investigate the performance of wireless network protocols that support and respond to the constraints implied by the social network they support.
Soft self-synchronising codes for self-calibrating communication (2005)

Self-calibrating designs are gaining momentum in both the computation and communication worlds. Instead of relying on the worst-case characterisation of design parameters, self calibrating systems determine autonomously the boundary of correct behaviour, and set design parameters accordingly. We focus on the communication task. We model errors due to over-aggressive operation and derive a channel model. We show that self-synchronising codes achieve completely reliable communication over this channel model, and study a known example, LEDR (level encoded 2-phase dual-rail), which is an improvement of the well-known dual-rail code. Then, we introduce a family of coding schemes which are a generalisation of LEDR, and study their performance over our channel model. We observe that the wiring overhead can be significantly reduced at the expense of a limited loss in reliability. Finally, we extend our channel model to include additive noise, and show that in this more general situation a specific instance of our coding scheme has similar or better performance than LEDR, at a smaller wiring overhead.
The Blue Edge - Blade Continuation (2019)

Airbus is certifying new H160 helicopter, first serial application of the Blue Edge™ rotor system, easily recognizable with its double leading edge swept shape. The reduction of the blade-vortex interaction noise has been the main driver of this design, studied since the 1990s, in collaboration between DLR, ONERA and Eurocopter (since become Airbus). From the project ERATO (Etude d'un Rotor Aéroacoustique Technologiquement Optimisé = aeroacoustically optimized rotor), the Blue Edge™ blade design became the trademark of the last rotor generation whose the history is summarized in Ref. 1. In 2014, a first extrapolation of this type of shape has been developed and tested in the frame of Bluecopter™ demonstrator as described in Ref. 2. The five-bladed bearingless rotor flew on EC135 in order to explore a low tip speed within new optimized eco airfoils and twist distribution. At the same time, new studies of Blue Edge™ design has been performed with other objectives: keeping the shape for the BVI acoustic reduction, multi-objective optimization of airfoils, twist and chord for better aerodynamic performances. This project, internally called PROTEGE (Pale pRincipale écOlogique en composiTe de nouvellE GEneration - New generation of ecological composite blade), flew on H225 demonstrator. The paper presents an overview of the design development of this new blade and the results about the dynamic behavior, the aerodynamic performances and acoustic reduction in various flight conditions. The acquired results bring new elements in the Blue Edge™blade which strengthen the interest of this design for the BVI acoustic reduction.
Surface Alignment and Anchoring Transitions in Nematic Lyotropic Chromonic Liquid Crystal (2010)

The surface alignment of lyotropic chromonic liquid crystals can not only be planar (tangential) but also homeotropic, with self-assembled aggregates perpendicular to the substrate, as demonstrated by mapping optical retardation and by three-dimensional imaging of the director field. With time, the homeotropic nematic undergoes a transition into a tangential state. The anchoring transition is discontinuous and can be described by a double-well anchoring potential with two minima corresponding to tangential and homeotropic orientation.
Enhancing the Charge Transfer of the Counter Electrode in Dye‐Sensitized Solar Cells Using Periodically Aligned Platinum Nanocups (2012)

A periodically aligned Pt nanocup array is employed as a counter electrode in dye-sensitized solar cells (DSSCs). The Pt nanocup array enhances the catalytic area, which results in a greater fill factor (FF) and higher short-circuit current (Jsc). A higher density of nanocups is preferable for the performance of DSSCs.
Probing the effects of spectral overlap on quantum-dot-based FRET: Ensemble and single molecule studies (2006)

The photoluminescence spectrum of a quasi-monodisperse semiconductor quantum dot (QD) population is composed of a continuum of extremely narrow single QD spectra. This is due to inhomogeneities in nanocrystal size within a population and the color-size dependency imposed by effects of carrier quantum confinements. We take advantage of this population heterogeneity to gain a unique insight into the fluorescence resonant energy transfer (FRET) process between a QD donor and proximal dye-labeled protein acceptors. Our ensemble and single-QD studies demonstrate that the spectral dependency of the energy transfer rate matches the acceptor absorption spectrum as predicted by Forster formalism. This allows ratiometric FRET measurements based on the QD donor emission.