gebhart/patrepeval huggingface dataset:
Supercritical fluid extraction of oil from millet bran (2000)

Abstract Proso millet bran [ Panicum miliaceum (L.)], variety Dakota White, was extracted with supercritical carbon dioxide (SC‐CO 2 ) to yield crude oil. The effects of operating parameters (pressure, temperature, and specific solvent flow) and of features of the raw material (moisture content and particle size) on oil extraction were investigated. Complete de‐oiling of ground millet bran pellets was achieved under 300 bar at 40°C with a specific solvent flow of 2–10 h −1 within 200 to 500 min. Solvent requirements were 20–30 kg CO 2 /kg raw material. Composition of crude SC‐CO 2 oil extracted under optimal conditions, i.e., fatty acid profile, amount of unsaponifiables, tocopherols, free fatty acids, sterols, sterol esters, waxes, hydrocarbons, and phospholipids, was compared to that of crude oil obtained by petroleum ether extraction. These two oils were similar in terms of fatty acid profile and amount of free fatty acids, unsaponifiables, peroxides, and tocopherols. They differed in respect to phospholipids (present in petroleum etherextracted oil and absent in SC‐CO 2 extracted oil), metals, and waxes (lower levels in SC‐CO 2 extracted oil). The effects of extraction procedures on oxidative stability of crude SC‐CO 2 oil were studied. Ensuring that all pieces of the extractor in contact with the oil were in stainless steel; cleaning the separator, i.e., washing with KOH, rinsing, purging with N 2 and CO 2 , and heating; performing a couple of extractions before the main extraction; and achieving the extraction without interruption all positively influenced the oxidative stability of the oil. Conversely, increasing CO 2 purity above 99.5% had no effect. Oxidative stability of the SC‐CO 2 oil extracted under these conditions was only slightly lower than that of the oil extracted with petroleum ether.
Radio interface performance of EDGE, a proposal for enhanced data rates in existing digital cellular systems (2002)

The use of alternative modulation to provide Enhanced Data rates for Global Evolution (EDGE) is currently being standardized for GSM by the European Telecommunications Standards Institute (ETSI), and is also adopted for IS-136 evolution by the Universal Wireless Communications Consortium (UWCC) in the USA. In this paper, the currently proposed radio interface for this concept and first link simulation results are presented. It is demonstrated that high-level modulation is feasible with an acceptable increase of complexity, and provides good performance, even if impacts like power amplifier nonlinearity, phase noise, frequency offset etc. are taken into account,.
Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors (2010)

We conclude that tasquinimod-induced up-regulation of TSP1 is part of a mechanism involving down-regulation of HIF1alpha and VEGF, which in turn leads to reduced angiogenesis via inhibition of the "angiogenic switch", that could explain tasquinimods therapeutic potential.
Improving the treatment of non‐Hodgkin lymphoma with antibody‐targeted radionuclides (2010)

Radioimmunotherapy of non-Hodgkin lymphoma comprises a (90)Y- or (131)I-labeled murine anti-CD20 IgG, but both agents also include a substantial dose of unlabeled anti-CD20 IgG given immediately before the radioconjugate to reduce its uptake in the spleen (primary normal B-cell antigen sink); this extends its plasma half-life and improves tumor visualization. Thus, these treatments combine an effective anti-CD20 radioconjugate with an unconjugated anti-CD20 antibody that is also therapeutically active, but the large anti-CD20 IgG predose ( approximately 900 mg) may diminish the tumor localization of the radioimmunoconjugate (eg, 10-35 mg). We have examined alternative approaches that enhance radionuclide targeting and improve antitumor responses. One uses a (90)Y-labeled anti-CD22 IgG (epratuzumab) combined with an antibody therapy regimen of a humanized anti-CD20 IgG (veltuzumab). Pretargeted radionuclide therapy using a trivalent, humanized, recombinant bispecific anti-CD20 antibody with a (90)Y-hapten-peptide is another highly effective method that is also less toxic than directly radiolabeled IgG. Finally, all approaches benefit from the addition of a consolidation-dosing regimen of the anti-CD20 IgG antibody. This article reviews these various options and discusses how some fundamental changes could potentially enhance the response and duration from radionuclide-targeted therapy.
Millipede-a MEMS-based scanning-probe data-storage system (2003)

Ultrahigh storage densities of up to 1 Tb/in./sup 2/ or more can be achieved by using local-probe techniques to write, read back, and erase data in very thin polymer films. The thermomechanical scanning-probe-based data-storage concept called Millipede combines ultrahigh density, small form factor, and high data rate. After illustrating the principles of operation of the Millipede, a channel model for the analysis of the readback process is introduced, and analytical results are compared with experimental data. Furthermore, the arrangement of data-storage fields as well as dedicated fields for servo and timing control is discussed, and system aspects related to the readback process, multiplexing, synchronization, and position-error-signal generation for tracking are introduced. Finally, the application of (d,k) modulation coding as a means to further increase areal density is presented, and the effect on the user data rates discussed.
Anti‐inflammatory synergy of MEN16132, a kinin B2 receptor antagonist, and dexamethasone in carrageenan‐induced knee joint arthritis in rats (2010)

Steroids and kinin B(2) receptor antagonists appear to relieve arthritic symptoms induced by carrageenan or LPS and act synergistically to inhibit joint inflammation. This could have interesting therapeutic implications, possibly opening the way for combination therapies in the control of inflammatory arthropathies.
Determinants of Retinal Microvascular Architecture in Normal Subjects (2009)

CVD risk factors are associated with retinal microvascular changes in healthy individuals without evidence of CVD, diabetes, or hypertension. CVD risk factors have different influences on the arteriolar and venular bed.
High performance, acene-based organic thin film transistors (2009)

1,4,8,11-Methyl-substituted 6,13-triethylsilylethynylpentacene shows extended pi-pi overlap when deposited from solution, yielding organic thin film transistors with high and reproducible hole mobility with negligible hysteresis.
Vaccination with recombinant paramyosin against the bovine lungworm Dictyocaulus viviparus considerably reduces worm burden and larvae shedding (2015)

Even though vaccination with the attenuated live vaccine was with 94% (geometric mean: 95%) reduction in larvae shedding and 93% (geometric mean: 94%) reduction in worm burden superior to rPMY vaccination, results using the latter are promising and show the potential for further development of a recombinant PMY-based vaccine against the bovine lungworm.
MICROMECHANICS OF FIBER EFFECT ON THE UNIAXIAL COMPRESSIVE STRENGTH OF CEMENTITIOUS COMPOSITES (1992)

A micromechanical model is presented for the uniaxial compressive strength of fiber reinforced cementitious composites (FRCC). The model is based on the classical models of compressive failure of brittle solids containing sliding microcracks that induce wing- crack growth under compressive loading. The concepts of increased microcrack sliding resistance and wing-crack growth retardation associated with fiber bridging are exploited to produce a strengthening effect of fibers on composite strength. The concept of defect introduction associated with fiber volume fraction is included to produce a composite strength degradation. The combined effects result in a composite compressive strength which increases initially and subsequently drops with increasing fiber content, as has been observed in FRCs reinforced with a variety of fibers. More accurate stress intensity factor calibrations for wing-crack growth and interaction are employed in the present paper. For the covering abstract of the conference see IRRD 862056.
ChemInform Abstract: Total Synthesis of Brevetoxin A (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A distortion matrix framework for high-resolution passive seismic 3-D imaging: application to the San Jacinto fault zone, California (2021)

SUMMARY Reflection seismic imaging usually suffers from a loss of resolution and contrast because of the fluctuations of the wave velocities in the Earth’s crust. In the literature, phase distortion issues are generally circumvented by means of a background wave velocity model. However, it requires a prior tomography of the wave velocity distribution in the medium, which is often not possible, especially in depth. In this paper, a matrix approach of seismic imaging is developed to retrieve a 3-D image of the subsoil, despite a rough knowledge of the background wave velocity. To do so, passive noise cross-correlations between geophones of a seismic array are investigated under a matrix formalism. They form a reflection matrix that contains all the information available on the medium. A set of matrix operations can then be applied in order to extract the relevant information as a function of the problem considered. On the one hand, the background seismic wave velocity can be estimated and its fluctuations quantified by projecting the reflection matrix in a focused basis. It consists in investigating the response between virtual sources and detectors synthesized at any point in the medium. The minimization of their cross-talk can then be used as a guide star for approaching the actual wave velocity distribution. On the other hand, the detrimental effect of wave velocity fluctuations on imaging is overcome by introducing a novel mathematical object: The distortion matrix. This operator essentially connects any virtual source inside the medium with the distortion that a wavefront, emitted from that point, experiences due to heterogeneities. A time reversal analysis of the distortion matrix enables the estimation of the transmission matrix that links each real geophone at the surface and each virtual geophone in depth. Phase distortions can then be compensated for any point of the underground. Applied to passive seismic data recorded along the Clark branch of the San Jacinto fault zone (SJFZ), the present method is shown to provide an image of the fault until a depth of 4 km over the frequency range 10–20Hz with an horizontal resolution of 80 m. Strikingly, this resolution is almost one eighth below the diffraction limit imposed by the geophone array aperture. The heterogeneities of the subsoil play the role of a scattering lens and of a transverse waveguide which increase drastically the array aperture. The contrast is also optimized since most of the incoherent noise is eliminated by the iterative time reversal process. Beyond the specific case of the SJFZ, the reported approach can be applied to any scales and areas for which a reflection matrix is available at a spatial sampling satisfying the Nyquist criterion.
Supplementary Figure 1 from A687V EZH2 Is a Driver of Histone H3 Lysine 27 (H3K27) Hypertrimethylation (2023)

&lt;p&gt;Supplementary Figure 1: Standard curves of recombinant modified histone proteins for quantification of western blots&lt;/p&gt;
DNA Fingerprint Characterization of Some Wine Grape Cultivars (1993)

In order to develop an objective and reliable method of grape identification, a DNA fingerprinting strategy similar in concept to that used to identify human beings was applied to a diverse group of cultivars, including the most important California wine grapes. DNA was extracted from young leaves and shoot tips of 43 accessions, digested with <i>Hind</i> III or <i>Eco</i> RV and probed with five low-copy number DNA clones selected from a grape genomic DNA library. Restriction length polymorphism analysis revealed unique patterns for all accessions presumed to be distinct cultivars. The probability that two different cultivars would share the same pattern was calculated to be 5.64 x 10<sup>-8</sup>. Identical banding patterns were produced by Zinfandel and Primitivo, supporting the hypothesis that these are synonyms for a single cultivar. Similarly, the pattern of the accession now designated as Pinot noir 19 (previously known as Gamay Beaujolais in California) was identical to that of Pinot noir 1, supporting ampelographic opinion that the former is in fact a form of Pinot noir and not a distinct cultivar. Pinot gris, widely held to be a berry color mutant of Pinot noir, also had the Pinot noir pattern. By contrast, identical patterns were not observed for single accessions of Petite Sirah and of Durif, thought by some to be synonymous. While the method described here does not detect intra-cultivar variation (clones and bud sports), the results obtained in this survey strongly suggest that this approach will be able to uniquely characterize additional grape cultivars and will serve as a valuable adjunct to ampelography.
Automated Peritoneal Dialysis: When and how to do it (1999)

A utomated peritoneal dialysis (APD) is the fastest growing dialysis treatment in the world at the present time. The evolution of this peritoneal dialysis (PD) modality is closely linked to the development ofnew automatic machines and to recent advances in prescription and monitoring of PD treatment. Since 1960, machines have been introduced to perform semiautomatic or fully automatic PD treatment. In the early days, peritoneal dialysis was mostly intermittent (IPD), featuring a total of 24 hours per week divided into three or more sessions. The applied technology was similar to the hemodialysis machines of those years. The slow peritoneal transport of solutes limited the efficiency of the treatments (1). In recent years, knowledge derived from the equilibration dialysis concept of continuous ambulatory peritoneal dialysis (CAPD) and the availability of plastic bags (2) have contributed to a rediscovery of intermittent peritoneal dialysis techniques. APD has today become a daily home treatment with automated nightly exchanges and one or two daily dwells, following the concept of reversed CAPD (continuous cyclic PD: CCPD) (3,4). The development of ad hoc machines, easy to use and with a simpler operator interface (the cyclers) (1), represented a further key factor in this process of evolution. Another important step in APD is represented by microchips and computers. These components, incorporated into PD cyclers, gave the machines greater programming flexibility. Thanks to these innovations, it is now possible to prescribe individualized fill volumes, variable tidal volumes and additional daytime automated exchanges, teledialysis, and memorized delivery control. At the same time, miniaturization of
Control Of Organ Transplant-Associated Graft-versus-Host Disease By Activated Host Lymphocyte Infusions (2004)

aHLI opens a novel therapeutic window to control solid-organ transplant-associated GvHD while preserving allograft integrity.
In vitro and in vivo characterization of mineralized hydroxyapatite/polycaprolactone-graphene oxide based bioactive multifunctional coating on Ti alloy for bone implant applications (2018)

Hydroxyapatite (HAP) is a form of naturally occurring calcium apatite present in bone and tooth enamel. It is an important biomaterial with diverse biomedical applications such as a surface coating for metallic orthopedic implants. Synthesized pristine HAP has poor mechanical properties, inferior wear resistance and has limits for directly used in bone tissue engineering applications. To address these limitations, we synthesized a suitable orthopedic implant hybrid material (M-HAP/PCL/GO) by using positively charged calcium ions of mineralized HAP (M-HAP) combined with Polycaprolactone-negatively charged graphene oxide (PCL-GO). The successfully synthesized M-HAP/PCL/GO composite was comprehensively characterized by Fourier-transform infrared spectroscopy (FT-IR), powder X-ray diffraction (XRD) and field-emission scanning electron microscopy (FE-SEM). The micro-hardness technique was used to determine the mechanical strength of M-HAP (315 ± 4 Hv), M-HAP/GO (370 ± 3 Hv) and M-HAP/PCL/GO (455 ± 5 Hv). M-HAP/PCL/GO was also tested for its anti-bactericidal impact against Staphylococcus aureus and Escherichia coli. MG63 osteoblast cells cultured on the M-HAP/PCL/GO composite (10 mg/mL) coated sample, displayed outstanding viability after 3 and 5 days of incubation at pH 7.4, which indicated that the composite is suitable material for bone implants and induces the cell proliferation. It was also tested in vivo in Wistar rats and was observably beneficial bone formation within 28 days post-implant operation. These tests proved that the M-HAP/PCL/GO composite can be considered as a prospective candidate for future bone implant applications. Keywords: Polycaprolactone, Graphene oxide, Hydroxyapatite, Bone implants, Antibacterial activity, MG63 osteoblasts cells, Surface coating
Modes of multiplication of brome mosaic virus in protoplasts from host and non-host plants. (1985)

[in Japanese]
Paraoxonase-2 Gene (PON2) G148 Variant Associated with Elevated Fasting Plasma Glucose in Noninsulin-Dependent Diabetes Mellitus1 (1997)

Defining the genetic determinants of NIDDM requires evidence from several complementary approaches, including both linkage and association analyses using both discrete phenotypes and intermediate quantitative traits. We tested for association between common genomic variation in three genes that map to chromosome 7q21-q22 and quantitative traits related to NIDDM in a sample of Oji-Cree. We found that a common genomic variation in codon 148 (alanine or glycine) of the paraoxonase-2 gene (PON2) demonstrated a significant association with a variation in fasting plasma glucose (P < 0.0001). Furthermore, we found a significant association between a variation in fasting plasma glucose and the interaction term comprised of a PON2 codon 148 genetic variation and the presence of noninsulin-dependent diabetes mellitus (NIDDM; P < 0.0001). We then analyzed subjects according to PON2 genotype and NIDDM status. In subjects with NIDDM, the PON2 codon 148 G/G homozygotes had significantly higher mean fasting plasma glucose than subjects with the other two genotypes (P < 0.0001). However, in non-NIDDM subjects, there was no difference in mean fasting plasma glucose among any of the genotypes. There was no association of the PON2 genotype with NIDDM itself, with impaired glucose tolerance, or with other quantitative traits related to NIDDM in this sample. These findings suggest that 1) the PON2 G148 gene variant worsens glycemia in subjects with NIDDM; 2) defining the physiological role of the PON2 gene product would be worthwhile; and 3) genetic factors can modify the severity of clinical phenotypes in subjects with NIDDM.
Three-dimensional architecture and evolution of Quaternary contourite drifts on the Vøring Plateau, Norwegian Sea (2022)

We use newly available, extensive two- and three-dimensional seismic datasets in the Vøring Plateau sector of the mid-Norwegan continental margin to investigate the architecture and evolution of Quaternary contourite drifts in the Norwegian Sea. The drifts typically comprise tens of cubic kilometres of sediment, often intercalated between lenses of glacigenic debris flows, and demonstrate migrating depositional centres along the upper and middle slope sectors of the mid-Norwegian margin through the last ~2.7 M.yr. By contrast, the contourite deposited in the southern Vøring Plateau area is anomalously large covering an area of ~17,000 km2 and comprising over 720 km3 of sediment. Correlation of internal drift surfaces with well-dated sediment cores shows that the massive, up to 280 m thick drift contains two major units that were deposited over the last two glacial-interglacial cycles, yielding extremely high sedimentation rates, comparable to those sourced directly from erosive meltwater-rich glaciers and fast-flowing ice streams. A revised evolutionary drift model provides an end-member example of how a combination of rapid glacially-derived sediment delivery and its subsequent transport and deposition by along-slope processes may exert considerable influence on continental margin morphology over geologically short timescales.
Titelei/Inhaltsverzeichnis (2015)

Das Buch beschäftigt sich mit verfassungs- und europarechtlichen Aspekten eines allgemeinen Mindestlohns. Der Ansatz ist interdisziplinär und bezieht auch andere sozialwissenschaftliche, insbesondere ökonomische Erwägungen ein. Neben den Freiheitsrechten des Europarechts und des Grundgesetzes wird der Mindestlohn auch in gleichheitsrechtlicher Perspektive betrachtet. Als „internalisierendes Sozialrecht“ dient er der Existenzsicherung der Arbeitnehmer. Aber belastet werden für dieses gesamtgesellschaftliche Ziel nur die Arbeitgeber. Weil die denkbaren Rechtfertigungen für diese Ungleichbehandlung im Ergebnis nicht überzeugen, ist der Mindestlohn verfassungswidrig. Der Gesetzgeber wäre auf Transferzahlungen zur Aufstockung nicht bedarfssichernder Arbeitsentgelte verwiesen. Den Abschluss bildet ein Blick auf alternative Modelle, insbesondere Kombilöhne nach Muster des US-amerikanischen Earned Income Tax Credit.
Androgen receptor as a potential sign of prostate cancer metastasis (2009)

AR mRNA expression is significantly higher in prostate cancer when compared to benign prostatic tissue.