gebhart/patrepeval huggingface dataset:
The Non-Rational Domain and the Limits of Economic Analysis: (2016)

Methodological discussions, while valuable, have one unfortunate feature: They can be interminable. Professors Michael Watts and Tibor Machan make important points relating to my article on the limits of economic analysis, and I am indebted to them for helping to clarify what would otherwise have been fuzzy issues for me. But in spite of the considerable agreement among the three of us, we may be talking at cross-purposes; Watts and Machan seem to have missed the central methodological concern presented in my article [1]. Let me attempt to redevelop my argument using, admittedly, a radically different approach. Perhaps, variety in presentation will add clarity to my own position and make a brief extension of the discussion useful. In order to avoid making this a debate over semantics, I will avoid the use of the term non-rational.
Phase I Study of STX 64 (667 Coumate) in Breast Cancer Patients: The First Study of a Steroid Sulfatase Inhibitor (2006)

STX64 is a potent, well-tolerated STS inhibitor. It inhibits STS activity in PBLs and tumor tissues and causes significant decreases in serum concentrations of steroids with estrogenic properties.
Linear and nonlinear techniques for multibeam joint processing in satellite communications (2012)

Existing satellite communication standards such as DVB-S2, operate under highly-efficient adaptive coding and modulation schemes thus making significant progress in improving the spectral efficiencies of digital satellite broadcast systems. However, the constantly increasing demand for broadband and interactive satellite links emanates the need to apply novel interference mitigation techniques, striving towards Terabit throughput. In this direction, the objective of the present contribution is to investigate joint multiuser processing techniques for multibeam satellite systems. In the forward link, the performance of linear precoding is investigated with optimal nonlinear precoding (i.e., dirty article coding) acting as the upper performance limit. To this end, the resulting power and precoder design problems are approached through optimization methods. Similarly, in the return link the concept of linear filtering (i.e., linear minimum mean square error) is studied with the optimal successive interference cancelation acting as the performance limit. The derived capacity curves for both scenarios are compared to conventional satellite systems where beams are processed independently and interbeam interference is mitigated through a four color frequency reuse scheme, in order to quantify the potential gain of the proposed techniques.
Androgen-regulated proliferation and gene transcription in a prostate smooth muscle cell line (PS-1). (1996)

Androgens play a key role in directing stromal-epithelial interactions in prostate gland development, in maintenance of adult phenotype, and in disease progression. To address the molecular mechanisms of androgen action in prostate stromal cells and the genes regulated by androgens in this cell type, a stromal cell line (PS-1) was developed from rat ventral prostate. The PS-1 cell line was adapted to chemically defined media and characterized as smooth muscle based on expression of desmin, smooth muscle alpha-actin, and nuclear androgen receptor, markers for prostate smooth muscle. To examine steroid hormone regulation, PS-1 cells were analyzed for response to a panel of steroid hormones in serum-free, chemically defined media. PS-1 cells were significantly growth stimulated by physiological concentrations of androgens (10nM) relative to other steroids tested. To ascertain whether this cell line could be used to examine androgen-regulated gene expression, differential display PCR was used to demonstrate the presence of androgen-regulated transcripts and provide the initial steps in cloning these genes. Replicate differential display PCR analyses showed consistent androgen stimulation of 16 messenger RNA species. Northern analysis confirmed androgen regulation of 6 species. Sequence analysis of each indicated no regions of significant homology or direct matches to existing sequences. Further study of the PS-1 stromal cell line and androgen-regulated genes identified here will provide a novel in vitro system for defining molecular mechanisms of androgen action in prostate stromal cells and the significance of stromal androgen-regulated genes to stromal-epithelial interactions.
EXPERIMENTAL DATA OF GAMMA-RAY PENETRATION INTO THE COMPARTMENTS OF A LIGHT AIRCRAFT CARRIER (1960)

Abstract : The penetration of gamma rays into compartments of an aircraft carrier from three different radioisotopes was measured. Co60, Cs137 and Ir192 sources were exposed on the Flight Deck and dosimeters were used to measure dose in two general areas of the ship at three different deck levels. Data of dose distribution are presented for the three sources used and for the different source points considered. Diagrams indicating source positions, detector positions, deck and compartment wall thicknesses and main structural member specifications are also presented. (Author)
Supplementary Table from Cyst(e)inase–Rapamycin Combination Induces Ferroptosis in Both <i>In Vitro</i> and <i>In Vivo</i> Models of Hereditary Leiomyomatosis and Renal Cell Cancer (2023)

Supplementary Table from Cyst(e)inase–Rapamycin Combination Induces Ferroptosis in Both &lt;i&gt;In Vitro&lt;/i&gt; and &lt;i&gt;In Vivo&lt;/i&gt; Models of Hereditary Leiomyomatosis and Renal Cell Cancer
Sensorimotor coupling in music and the psychology of the groove. (2011)

The urge to move in response to music, combined with the positive affect associated with the coupling of sensory and motor processes while engaging with music (referred to as sensorimotor coupling) in a seemingly effortless way, is commonly described as the feeling of being in the groove. Here, we systematically explore this compelling phenomenon in a population of young adults. We utilize multiple levels of analysis, comprising phenomenological, behavioral, and computational techniques. Specifically, we show (a) that the concept of the groove is widely appreciated and understood in terms of a pleasurable drive toward action, (b) that a broad range of musical excerpts can be appraised reliably for the degree of perceived groove, (c) that the degree of experienced groove is inversely related to experienced difficulty of bimanual sensorimotor coupling under tapping regimes with varying levels of expressive constraint, (d) that high-groove stimuli elicit spontaneous rhythmic movements, and (e) that quantifiable measures of the quality of sensorimotor coupling predict the degree of experienced groove. Our results complement traditional discourse regarding the groove, which has tended to take the psychological phenomenon for granted and has focused instead on the musical and especially the rhythmic qualities of particular genres of music that lead to the perception of groove. We conclude that groove can be treated as a psychological construct and model system that allows for experimental exploration of the relationship between sensorimotor coupling with music and emotion.
Supplementary Table 1 from Unexpected Dissemination Patterns in Lymphoma Progression Revealed by Serial Imaging within a Murine Lymph Node (2023)

&lt;p&gt;PDF file - 69K, Comparison between the LNIWC technique and other common techniques&lt;/p&gt;
Undetected Toxicity Risk in Pharmacogenetic Testing for Dihydropyrimidine Dehydrogenase (2015)

Fluoropyrimidines, the mainstay agents for the treatment of colorectal cancer, alone or as a part of combination therapies, cause severe adverse reactions in about 10%-30% of patients. Dihydropyrimidine dehydrogenase (DPD), a key enzyme in the catabolism of 5-fluorouracil, has been intensively investigated in relation to fluoropyrimidine toxicity, and several DPD gene (DPYD) polymorphisms are associated with decreased enzyme activity and increased risk of fluoropyrimidine-related toxicity. In patients carrying non-functional DPYD variants (c.1905+1G>A, c.1679T>G, c.2846A>T), fluoropyrimidines should be avoided or reduced according to the patients' homozygous or heterozygous status, respectively. For other common DPYD variants (c.496A>G, c.1129-5923C>G, c.1896T>C), conflicting data are reported and their use in clinical practice still needs to be validated. The high frequency of DPYD polymorphism and the lack of large prospective trials may explain differences in studies' results. The epigenetic regulation of DPD expression has been recently investigated to explain the variable activity of the enzyme. DPYD promoter methylation and its regulation by microRNAs may affect the toxicity risk of fluoropyrimidines. The studies we reviewed indicate that pharmacogenetic testing is promising to direct personalised dosing of fluoropyrimidines, although further investigations are needed to establish the role of DPD in severe toxicity in patients treated for colorectal cancer.
Retro-Modelling Technique for Permittivity Measurements in the Range from 2.2 to 2.6 GHz for Medical Applications (2021)

In this study we present a permittivity measurement technique based on retro-modelling of a resonant cavity in the frequency range from 2.2 to 2.6 GHz that allows for a more arbitrary sample shape than traditional cavity perturbation techniques. It is shown that the resolution of the retro-modelling technique can be improved if the invoked modes in the sample and in the surrounding cavity space are of different type or indexation, a condition that must clearly be avoided in classical perturbation techniques. The measurement method was applied to a ceramic sample of unknown permittivity which was retro-modelled to $\varepsilon^{\prime}=19.35$ and $\sigma=0.009S/m$ with a remaining combined error of geometry and permittivity deviations between measurement and simulation of &#x003C;0.1 &#x0025; in frequency and 22&#x0025; in Q-value at the target resonance. This technique will allow us to identify suitable dielectric materials to improve the feed efficiency of our magnetic field applicator which is currently being developed for microwave breast cancer detection.
LASER-SCANNING FLOW CYTOMETER WITH A THREE-DIMENSIONAL MICROFLUIDIC CHIP (2008)

We have developed a new flow cytometer utilizing a three-dimensional (3D) microfluidic disposable plastic chip and real-time multi-spectral deconvolution analysis. The chip has microfluidic channels where sample particles flow down in the center of each channel. Three laser diodes (LDs) are used, of which the laser beams are scanned with a polygonal mirror, and only the centers of the microfluidic channels are irradiated with pulsed flashes. Emitted fluorescence light is separated in spectral distribution with a grating and is detected with a 32-arrayed photomultiplier tube (PMT). The spectral signal is deconvoluted with reference spectra of all fluorescent components.
Immunosuppression and atypical infections in CML patients treated with dasatinib at 140 mg daily (2009)

Dasatinib acts not only anti-neoplastic in CML but may also act as an immunosuppressive agent when applied at 140 mg daily, and produces frequent pleural effusions and weight loss in advanced CML.
VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF (2011)

Vascular endothelial growth factor (VEGF) is known to activate proliferation, migration, and survival pathways in endothelial cells through phosphorylation of VEGF receptor-2 (VEGFR-2). VEGF has been incorporated into biomaterials through encapsulation, electrostatic sequestration, and covalent attachment, but the effect of these immobilization strategies on VEGF signaling has not been thoroughly investigated. Further, although growth factor internalization along with the receptor generally occurs in a physiological setting, whether this internalization is needed for receptor phosphorylation is not entirely clear. Here we show that VEGF covalently bound through a modified heparin molecule elicits an extended response of pVEGFR-2 in human umbilical vein endothelial cells (HUVECs) and that the covalent linkage reduces internalization of the growth factor during receptor endocytosis. Optical tweezer measurements show that the rupture force required to disrupt the heparin-VEGF-VEGFR-2 interaction increases from 3-8 pN to 6-12 pN when a covalent bond is introduced between VEGF and heparin. Importantly, by covalently binding VEGF to a heparin substrate, the stability (half-life) of VEGF is extended over three-fold. Here, mathematical models support the biological conclusions, further suggesting that VEGF internalization is significantly reduced when covalently bound, and indicating that VEGF is available for repeated phosphorylation events.
Evaluation of the Access Bio CareStart™ rapid SARS-CoV-2 antigen test in asymptomatic individuals tested at a community mass-testing program in Western Massachusetts (2021)

Abstract Background Point-of-care antigen-detecting rapid diagnostic tests (RDTs) for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) represent a scalable tool for SARS-CoV-2 infections surveillance. Data on their performance in real-world community settings is paramount for their implementation. Method We evaluated the accuracy of CareStart™ COVID-19 Antigen test (CareStart) in a testing site in Holyoke, Massachusetts. We compared CareStart to a SARS-CoV-2 reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) reference, using anterior nasal swab samples. We calculated the sensitivity, specificity, and expected positive and negative predictive values at different SARS-CoV-2 prevalence estimates. Results We performed 666 tests on 591 unique individuals. 573 (86%) were asymptomatic. There were 52 positive tests by RT-qPCR. The sensitivity of CareStart was 49.0% (95% Confidence Interval (CI): 34.8 – 63.4) and specificity was 99.5% (95% CI: 98.5 – 99.9). Among positive RT-qPCR tests, the median cycle threshold (Ct) was significantly lower in samples that tested positive on CareStart. Using a Ct ≤ 30 as a benchmark for positivity increased the sensitivity to 64.9% (95% CI: 47.5 – 79.8). Conclusions CareStart has a high specificity and moderate sensitivity. The utility of RDTs, such as CareStart, in mass implementation should prioritize use cases in which a higher specificity is more important.
Letter to the Editor Is TESA Passé? (2006)

As a urologist who has practiced male infertility in Los Angeles for the past 26 years, I read with interest the two articles that dealt with testicular sperm aspiration via TESE and TESA in the Jan/Feb 2006 issue of Journal of Andrology and feel that a comment about these two manuscripts is warranted. First of all, both articles were, in my humble opinion, well designed to answer a number of nagging questions about sperm aspiration techniques, and the authors of both are to be congratulated for putting down on paper their vast experience on this important topic. However, in reading these two manuscripts, I got the feeling that there was at least one hidden, what I would even call subliminal, message between the lines of these two studies that I think needs to be addressed, at least by a urologist. The subliminal message that I am referring to is that TESE is considered by the cognoscenti of male infertility to be a more involved procedure than TESA, since TESE 1) entails more preparation, ie, an operating suite is required, and 2) is more invasive and painful, hence it needs to be done under general anesthesia. I respectfully submit that this is inaccurate. TESE is, from a surgical point of view, little more than a testis biopsy, and in my ∼ 26 years at our institution doing this in dozens of patients, save for one or two who requested general anesthesia because of perceived testisphobia (sic), I don't recall ever doing a TESE, regardless of whether it was multifocal (sometimes up to 6+ biopsies per testis) or unifocal, under general anesthesia and in an operating suite. In fact, at UCLA it would cost almost as much as many IVF centers charge for ICSI/IVF if I were to do a testis biopsy in the operating suite—and this does not include the surgical fee for the TESE. Cost is therefore one of a number of reasons why TESE is done under local anesthesia in the office setting. With TESE, complete anesthesia of the area, whether unilateral or bilateral, can be obtained by an intradermally injected anesthetic plus a cord block. While a few of our patients undergoing TESE have had a vasovagal reflex which simply responded to intranasal ammonia, we have never lost a testis nor had a complication of the cord block that necessitated any corrective therapy. I for one have always assumed that those physicians who did TESA did so because they were primarily andrologists and were, therefore, not surgically trained. While this may be true or not, based on the powerful data of these two excellent studies, it seems prudent that those who perform TESA in preference to TESE need to rethink their reasons for ever considering TESA as a method of sperm aspiration, particularly in nonobstructive azoospermia. Respectfully yours, Jacob Rajfer, MD
Verification Coverage: When is Enough, Enough? (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Encapsulation of DNA with neutral glycocluster nanoparticles. A step toward artificial viruses (2003)

Number and size-controlled macromolecular associations are common in biology with viruses as a typical example. We report here a novel example of artificial viruses, in which the double-helical DNA is coated with 4-nm sized neutral glycocluster nanoparticles (GNPs). The resulting "glycoviruses" are compactly-packed, well charge-shielded (zeta approximately = 0 mV), and effectively transfect cell cultures without notable cytotoxicity.
Probing the Quantum Interference between Singly and Doubly Resonant Top-Quark Production in pp Collisions at s=13  TeV with the ATLAS Detector (2018)

This Letter presents a normalized differential cross-section measurement in a fiducial phase-space region where interference effects between top-quark pair production and associated production of a single top quark with a W boson and a b-quark are significant. Events with exactly two leptons (ee, μμ, or eμ) and two b-tagged jets that satisfy a multiparticle invariant mass requirement are selected from 36.1 fb^{-1} of proton-proton collision data taken at sqrt[s]=13 TeV with the ATLAS detector at the LHC in 2015 and 2016. The results are compared with predictions from simulations using various strategies for the interference. The standard prescriptions for interference modeling are significantly different from each other but are within 2σ of the data. State-of-the-art predictions that naturally incorporate interference effects provide the best description of the data in the measured region of phase space most sensitive to these effects. These results provide an important constraint on interference models and will guide future model development and tuning.
N-oxide as a potential function in the design of enzyme inhibitors. Application to 2,3-epoxysqualene-sterol cyclases (1985)

M. Cerutti, L. Delprino, L. Cattel, P. Bouvier-Navé, A. Duriatti, F. Schuber and P. Benveniste, J. Chem. Soc., Chem. Commun., 1985, 1054 DOI: 10.1039/C39850001054
Additive pulse compression modelocking using polarisation evolution (1991)

Single-mode rare-earth-doped fibers are an ideal medium for the generation of ultra-short pulses. Long interaction lengths for nonlinear processes allow a very effective exploitation of nonlinear intra-cavity pulse-shaping mechanisms and allow to mode-lock the full glass laser bandwidth even in the presence of dominant inhomogeneous broadening. Stable femto-second pulse generation in fiber lasers generally requires the presence of both passive frequency- and amplitude modulation to be present in the cavity.
Endogenous T cells prevent tumor immune escape following adoptive T cell therapy (2019)

While the outcome of adoptive T cell therapy (ACT) is typically correlated with the functionality of the inoculated T cells, the role of the endogenous T cells is unknown. The success of checkpoint blockade therapy has demonstrated the potentially curative value of preexisting tumor-primed T cells in cancer treatment. Given the results from checkpoint blockade therapy, we hypothesized that endogenous T cells contribute to long-term survival following ACT. Here, we describe a therapeutic approach combining ACT with an oncolytic vaccine that allows simultaneous analysis of antitumor immunity mediated by transferred and endogenous T cells. We found that, in addition to promoting the expansion and tumor infiltration of the transferred T cells, oncolytic vaccines boosted tumor-primed host T cells. We determined that transferred T cells contributed to rapid destruction of large tumor masses while endogenous T cells concurrently prevented the emergence of antigen-loss variants. Moreover, while transferred T cells disappeared shortly after tumor regression, endogenous T cells secured long-term memory with a broad repertoire of antigen specificity. Our findings suggest that this combination strategy may exploit the full potential of ACT and tumor-primed host T cells to eliminate the primary tumor, prevent immune escape, and provide long-term protective memory.