gebhart/patrepeval huggingface dataset:
Measurement of Spin Correlation in Top-Antitop Quark Events and Search for Top Squark Pair Production inppCollisions ats=8  TeVUsing the ATLAS Detector (2015)

A measurement of spin correlation in tt[over ¯] production is presented using data collected with the ATLAS detector at the Large Hadron Collider in proton-proton collisions at a center-of-mass energy of 8 TeV, corresponding to an integrated luminosity of 20.3 fb^{-1}. The correlation between the top and antitop quark spins is extracted from dilepton tt[over ¯] events by using the difference in the azimuthal angle between the two charged leptons in the laboratory frame. In the helicity basis the measured degree of correlation corresponds to A_{helicity}=0.38±0.04, in agreement with the standard model prediction. A search is performed for pair production of top squarks with masses close to the top quark mass decaying to predominantly right-handed top quarks and a light neutralino, the lightest supersymmetric particle. Top squarks with masses between the top quark mass and 191 GeV are excluded at the 95% confidence level.
The effect of deep trench isolation, trench isolation and sub-collector doping on the electrostatic discharge (ESD) robustness of radio frequency (RF) ESD STI-bound P+/N-well diodes in BiCMOS silicon germanium technology (2003)

This paper demonstrates the independent and combined effect of deep trench (DT) isolation, trench isolation (TI), and sub-collector on shallow trench isolation (STI) -bound p+/n-well ESD diode structures in a 120 and 200 GHz fT BiCMOS Silicon Germanium technology.
Flavin-Dependent Photocleavage of RNA at G·U Base Pairs (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTFlavin-Dependent Photocleavage of RNA at G·U Base PairsPetra Burgstaller and Michael FamulokView Author Information Institut für Biochemie-Genzentrum Feodor-Lynen-Strasse 25, 81377 München, GermanyCite this: J. Am. Chem. Soc. 1997, 119, 5, 1137–1138Publication Date (Web):February 5, 1997Publication History Received19 August 1996Published online5 February 1997Published inissue 1 February 1997https://pubs.acs.org/doi/10.1021/ja962918phttps://doi.org/10.1021/ja962918prapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views389Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Bond cleavage,Crystal cleavage,Genetics,Nucleic acids,Peptides and proteins Get e-Alerts
P-OPT-01 TRACKING CHARACTERISTICS OF A TRIANGULAR APERTURE MOUNTED OPTICAL HEAD SLIDER APPLIED A POLARIZED VIOLET LASER SOURCE(Optical Storage/Optical Devices for Storage,Technical Program of Poster Session) (2009)

Utilizing a triangular aperture for high-density "near-field recording" is thought to be one of the most promising breakthroughs to realize both higher spatial resolution and higher signal output simultaneously. We have already reported 300 nm to 100 nm line-and-space patterns readout performances of the triangular aperture, clarifying the influence of the polarization direction on the readout signals. This paper reports signal output performance in radial direction (tracking characteristics) using linearly arranged line-and-space patterns.
Polarization Induced Electro-Functionalization of Pore Walls: A Contactless Technology (2019)

This review summarizes recent advances in micro- and nanopore technologies with a focus on the functionalization of pores using a promising method named contactless electro-functionalization (CLEF). CLEF enables the localized grafting of electroactive entities onto the inner wall of a micro- or nano-sized pore in a solid-state silicon/silicon oxide membrane. A voltage or electrical current applied across the pore induces the surface functionalization by electroactive entities exclusively on the inside pore wall, which is a significant improvement over existing methods. CLEF's mechanism is based on the polarization of a sandwich-like silicon/silicon oxide membrane, creating electronic pathways between the core silicon and the electrolyte. Correlation between numerical simulations and experiments have validated this hypothesis. CLEF-induced micro- and nanopores functionalized with antibodies or oligonucleotides were successfully used for the detection and identification of cells and are promising sensitive biosensors. This technology could soon be successfully applied to planar configurations of pores, such as restrictions in microfluidic channels.
Synthesis of Emulsion-Templated Poly(acrylamide) Using CO2-in-Water Emulsions and Poly(vinyl acetate)-Based Block Copolymer Surfactants (2007)

We present here a simple and generic method for producing inexpensive and biodegradable polymer surfactants for use in supercritical CO2. Low molecular weight (Mw < 7000 g/mol) hydroxyl-terminated poly(vinyl acetate) (PVAc−OH) was synthesized using optimized reaction conditions and isopropyl ethanol (IPE) as the chain transfer agent. Oligomeric PVAc−OH (OVAc−OH, Mw < 3000 g/mol) was then obtained by supercritical fluid fractionation. The OVAc−OH species was converted to the imidazole ester by reaction with carbonyl diimidazole (CDI) and CO2-soluble surfactants were produced by coupling these reactive blocks with poly(ethylene glycol) methyl ethers or poly(ethylene glycol) diols. The surfactants found to be extremely effective in the production of stable CO2-in-water (C/W) emulsions, which were then used as templates to produce emulsion-templated materials with unprecedentedly high levels of porosity for materials produced by this route. It was shown that these hydrocarbon surfactants can out-perform perfluorinated species in applications of this type.
Use of interleukin-11 to stimulate platelet production in myelodysplastic syndromes (2006)

For most patients with myelodysplastic syndromes (MDS), treatment options are limited to non-curative approaches, most of which aim at counteracting cytopenia(s). Apart from continuous transfusions...
Flexible Synthesis of Polyhydroxylated 2,2-Disubstituted Pyrrolidines (2000)

Many polyhydroxylated pyrrolidines and piperidines have attracted considerable attention because they have been shown to selectively inhibit the oligosaccharide processing enzymes by mimicking the transition state.2 Especially their potential to exhibit antibacterial, antiviral3 and cancerostatic activities4 has led to a tremendous interest and demand for flexible synthetic strategies.
Human Nucleoporins Promote HIV-1 Docking at the Nuclear Pore, Nuclear Import and Integration (2012)

The nuclear pore complex (NPC) mediates nucleo-cytoplasmic transport of macromolecules and is an obligatory point of passage and functional bottleneck in the replication of some viruses. The Human Immunodeficiency Virus (HIV) has evolved the required mechanisms for active nuclear import of its genome through the NPC. However the mechanisms by which the NPC allows or even assists HIV translocation are still unknown. We investigated the involvement of four key nucleoporins in HIV-1 docking, translocation, and integration: Nup358/RanBP2, Nup214/CAN, Nup98 and Nup153. Although all induce defects in infectivity when depleted, only Nup153 actually showed any evidence of participating in HIV-1 translocation through the nuclear pore. We show that Nup358/RanBP2 mediates docking of HIV-1 cores on NPC cytoplasmic filaments by interacting with the cores and that the C-terminus of Nup358/RanBP2 comprising a cyclophilin-homology domain contributes to binding. We also show that Nup214/CAN and Nup98 play no role in HIV-1 nuclear import per se: Nup214/CAN plays an indirect role in infectivity read-outs through its effect on mRNA export, while the reduction of expression of Nup98 shows a slight reduction in proviral integration. Our work shows the involvement of nucleoporins in diverse and functionally separable steps of HIV infection and nuclear import.
Graphene‐Based Intrinsically Stretchable 2D‐Contact Electrodes for Highly Efficient Organic Light‐Emitting Diodes (2022)

Intrinsically stretchable organic light-emitting diodes (ISOLEDs) are becoming essential components of wearable electronics. However, the efficiencies of ISOLEDs have been highly inferior compared with their rigid counterparts, which is due to the lack of ideal stretchable electrode materials that can overcome the poor charge injection at 1D metallic nanowire/organic interfaces. Herein, highly efficient ISOLEDs that use graphene-based 2D-contact stretchable electrodes (TCSEs) that incorporate a graphene layer on top of embedded metallic nanowires are demonstrated. The graphene layer modifies the work function, promotes charge spreading, and impedes inward diffusion of oxygen and moisture. The work function (WF) of 3.57 eV is achieved by forming a strong interfacial dipole after deposition of a newly designed conjugated polyelectrolyte with crown ether and anionic sulfonate groups on TCSE; this is the lowest value ever reported among ISOLEDs, which overcomes the existing problem of very poor electron injection in ISOLEDs. Subsequent pressure-controlled lamination yields a highly efficient fluorescent ISOLED with an unprecedently high current efficiency of 20.3 cd A<sup>-1</sup> , which even exceeds that of an otherwise-identical rigid counterpart. Lastly, a 3 inch five-by-five passive matrix ISOLED is demonstrated using convex stretching. This work can provide a rational protocol for designing intrinsically stretchable high-efficiency optoelectronic devices with favorable interfacial electronic structures.
Learning from 1,000,000 user-uploaded faces (2009)

This paper combines two face detection algorithms to create a hybrid method which is more accurate and robust than either of the original methods. The face detectors are compared using a database of 1,000 user uploaded photos, which is a small subset of a much larger 1 million photo database that was generated through a popular online application that enables people to upload facial photos and to accurately locate the face in each photo.
Alkylidyne Complexes of Molybdenum and Tungsten That Contain the [(3,4,5-C6H2F3NCH2CH2)2NMe]2- Ligand (2001)

Reduction of (C6F5NHCH2CH2)2NMe with LiAlH4 produces (3,4,5-C6H2F3NHCH2CH2)2NMe (H2[F3NMe]) in good yield. Reactions between H2[F3NMe] and MCl4 (M = Mo, W) in the presence of NEt3 yield pseudooctahedral paramagnetic compounds of the type [Et3NH]{[F3NMe]MCl3}. Treatment of [Et3NH]{[F3NMe]MoCl3} with 3 equiv of Me3CCH2MgCl produced five-coordinate [F3NMe]Mo(CH2CMe3)(CCMe3), while treatment with 3 equiv of Me3SiCH2MgCl produced five-coordinate paramagnetic [F3NMe]Mo(CH2SiMe3)2. Upon heating, [F3NMe]Mo(CH2SiMe3)2 is converted into diamagnetic {[F3NMe]Mo(CSiMe3)}2. Reactions between [Et3NH]{[F3NMe]WCl3} and Me3CCH2MgCl or Me3SiCH2MgCl lead to five-coordinate diamagnetic complexes of the type [F3NMe]W(CH2R)(CR), where R = CMe3, SiMe3 respectively. X-ray studies confirmed the structures of [F3NMe]Mo(CH2CMe3)(CCMe3) and {[F3NMe]Mo(CSiMe3)}2.
Design of color screen tile vector sets (2010)

For electrophotographic printers, periodic clustered screens are preferable due to their homogeneous halftone texture and their robustness to dot gain. In traditional periodic clustered-dot color halftoning, each color plane is independently rendered with a different screen at a different angle. However, depending on the screen angle and screen frequency, the final halftone may have strong visible moiré due to the interaction of the periodic structures, associated with the different color planes. This paper addresses issues on finding optimal color screen sets which produce the minimal visible moiré and homogeneous halftone texture. To achieve these goals, we propose new features including halftone microtexture spectrum analysis, common periodicity, and twist factor. The halftone microtexture spectrum is shown to predict the visible moiré more accurately than the conventional moiré-free conditions. Common periodicity and twist factor are used to determine whether the halftone texture is homogeneous. Our results demonstrate significant improvements to clustered-dot screens in minimizing visible moiré and having smooth halftone texture.
Evaluation of synthetic novel ether aminophosphoglycerides for glucocorticoid-receptor complex modulator activity. (1991)

Modulator is an endogenous low-mol wt regulator of the glucocorticoid-receptor complex. Structural analysis of purified modulator suggested that it was a novel ether aminophosphoglyceride (Bodine and Litwack 1988b). Analogs of the putative modulator structure have now been synthesized. The synthetic compounds are 1-O-(6-carboxylhexyl)-glycero-3-phosphoserine and the sn-2-methoxy and sn-1-ethylester derivatives. Like modulator, these novel synthetic compounds are water soluble. However, thin-layer chromatography and spectroscopic analysis of these phosphoglycerides indicated significant structural differences between modulator and the synthetic analogs. In particular, the chromatographic behavior of the compounds suggests that modulator is more highly charged than the synthetic derivatives. The synthetic compounds, as well as lysophosphatidylserine, were also tested for in vitro modulator activity using the glucocorticoid-receptor complex activation inhibition and steroid-binding stabilization assays. None of the analogs exhibited modulator activity in these assays. However, the synthetic compounds were generally less detrimental to receptor steroid-binding than lysophosphatidylserine. From this work, we conclude that although modulator is not mimicked by one of these synthetic phosphoglycerides, a starting point for future structure-function studies has nonetheless been established.
Mental health and associated factors among young offenders in Chile: a cross‐sectional study (2017)

Our findings suggest that greater efforts must be made to identify vulnerable young people much earlier. Few of these young offenders with mental health problems had been well adjusted in health, education or socially before this period of detention. © 2017 The Authors. Criminal Behaviour and Mental Health Published by John Wiley & Sons Ltd.
QoS Considerations for HSDPA and Performance Results for Different Services (2006)

The functional split between the centralized radio network controller (RNC) and the base station (node-B) presents new challenges and opportunities for implementing QoS control for HSDPA. In this paper we present different options for implementing QoS over HSDPA, and we focus particularly on the shared responsibility between the QoS aware algorithms at the RNC and the node-B. Different strategies for QoS aware node-B packet schedulers are discussed. The paper is concluded with network performance results for different services over HSDPA, ranging from simple best effort traffic, to constant bit rate streaming, and voice over IP. For these services we show capacity gains of up to 40% from using QoS-aware packet scheduling.
Accelerated growth of B16BL6 tumor in mice through efficient uptake of their own exosomes by B16BL6 cells (2017)

Exosomes are extracellular vesicles released by various cell types and play roles in cell-cell communication. Several studies indicate that cancer cell-derived exosomes play important pathophysiological roles in tumor progression. Biodistribution of cancer cell-derived exosomes in tumor tissue is an important factor for determining their role in tumor proliferation; however, limited studies have assessed the biodistribution of exosomes in tumor tissues. In the present study, we examined the effect of cancer-cell derived exosomes on tumor growth by analyzing their biodistribution. Murine melanoma B16BL6-derived exosomes increased the proliferation and inhibited the apoptosis of B16BL6 cells, which was associated with an increase and decrease in the levels of proliferation- and apoptosis-related proteins, respectively. GW4869-induced inhibition of exosome secretion decreased the proliferation of B16BL6 cells, and treatment of GW4869-treated cells with B16BL6-derived exosomes restored their proliferation. Next, we treated B16BL6 tumors in mice with B16BL6-derived exosomes and examined the biodistribution and cellular uptake of these exosomes. After the intratumoral injection of radiolabeled B16BL6-derived exosomes, most radioactivity was detected within the tumor tissues of mice. Fractionation of cells present in the tumor tissue showed that fluorescently labeled exosomes were mainly taken up by B16BL6 cells. Moreover, intratumoral injection of B16BL6-derived exosomes promoted tumor growth, whereas intratumoral injection of GW4869 suppressed tumor growth. These results indicate that B16BL6 cells secrete and take up their own exosomes to induce their proliferation and inhibit their apoptosis, which promotes tumor progression.
First Synthesis of Poly(ethene-co-1,3-butadiene) with Neodymocene Catalysts (2000)

International audience
Serial H3K27M cell-free tumor DNA (cf-tDNA) tracking predicts ONC201 treatment response and progression in diffuse midline glioma (2022)

Our work demonstrates the feasibility and potential utility of serial cf-tDNA in both plasma and CSF of DMG patients to supplement radiographic monitoring. Patterns of change in H3K27M VAF over time demonstrate clinical utility in terms of predicting progression and sustained response and possible differentiation of pseudo-progression and pseudo-response.
ChemInform Abstract: Formal Total Synthesis of Kendomycin by Way of Alkyne Metathesis/Gold Catalysis. (2014)

Abstract The key steps comprise a late stage ring‐closing metathesis reaction employing the latest generation of alkyne metathesis catalysts followed by a gold‐catalyzed hydroalkoxylation.
Fabrication and Characterization of ZnO Nanowire-based Piezoelectric Nanogenerators for Low Frequency Mechanical Energy Harvesting (2015)

The present work investigates the possibility to charge a Lithium micro-battery (LiB) via direct conversion of ambient mechanical energy into electricity using piezoelectric ZnO nanowire (NW) based microgenerators (PGs). An estimate is provided for the power levels at the different stages of mechanical-to-electrical energy conversion chain, in the following areas: (1) PG output, (2) power management block and (3) LiB storage unit. Also covered in this work is the synthesis, which is a prerequisite for realising such PGs. ZnO NWs of 2 μm in length and 200 nm in diameter have been grown using a low temperature (<150 °C) hydrothermal process on 100 μm thick PET substrates (25 × 25 mm2). Substrates containing bi-layer metal layers with dissimilar electro-negativities functioned as a galvanic cell in the growth nutrients, which acted as an electrolyte medium. This necessitated ZnO NWs growth on conductive surfaces, even in the absence of seed layers and/or substrate with specific lattice parameters. Finally, the assembly steps undertaken to realise the fully functional PGs are discussed, and the performances of the final PG are described thereafter. Subjecting such devices to a 10 Hz sinusoidal bending force resulted in a measured PG output of ∼56 mV peak to peak, on 1 MΩ resistive load.
A Convolutional Neural Network for Automatic Characterization of Plaque Composition in Carotid Ultrasound (2016)

Characterization of carotid plaque composition, more specifically the amount of lipid core, fibrous tissue, and calcified tissue, is an important task for the identification of plaques that are prone to rupture, and thus for early risk estimation of cardiovascular and cerebrovascular events. Due to its low costs and wide availability, carotid ultrasound has the potential to become the modality of choice for plaque characterization in clinical practice. However, its significant image noise, coupled with the small size of the plaques and their complex appearance, makes it difficult for automated techniques to discriminate between the different plaque constituents. In this paper, we propose to address this challenging problem by exploiting the unique capabilities of the emerging deep learning framework. More specifically, and unlike existing works which require a priori definition of specific imaging features or thresholding values, we propose to build a convolutional neural network (CNN) that will automatically extract from the images the information that is optimal for the identification of the different plaque constituents. We used approximately 90 000 patches extracted from a database of images and corresponding expert plaque characterizations to train and to validate the proposed CNN. The results of cross-validation experiments show a correlation of about 0.90 with the clinical assessment for the estimation of lipid core, fibrous cap, and calcified tissue areas, indicating the potential of deep learning for the challenging task of automatic characterization of plaque composition in carotid ultrasound.
Glomerular uracil nucleotide synthesis: effects of diabetes and protein intake (1988)

The biosynthesis of uridine 5'-triphosphate (UTP), uridine 5'-diphosphohexoses, and 5'-diphosphohexosamines (UDP-sugars) was studied in isolated rat glomeruli 48 h after streptozotocin-induced diabetes. Compared with control, diabetic glomeruli demonstrated an increase in the following: exogenous orotate utilization, orotate incorporation into UTP and UDP-sugars, UTP accretion rate, and UDP-sugar pool size. Since these phenomena were not associated with enhanced biosynthesis of orotate de novo, the increased glomerular UDP-sugar bioavailability in diabetes is due to enhanced utilization of exogenous orotate. Plasma concentrations of orotate and uridine were measured in control, sham operated, and unilaterally nephrectomized rats receiving 5, 20, or 60% protein diets. The concentration of pyrimidine precursors correlated directly with protein intake, with doubling at the 60% dietary protein level. In conclusion, glomerular uracil ribonucleotide biosynthesis may be modulated by the quantity of dietary protein. Because UDP-sugars are necessary for basement membrane material formation, an increase in their bioavailability may be part of the metabolic change responsible for diabetic glomerulosclerosis. Diets with high protein content could augment this metabolic alteration.
House Dust Mite Induced Lung Inflammation Does Not Alter Circulating Vitamin D Levels (2014)

Low circulating levels of 25-hydroxyvitamin D [25(OH)D] are associated with chronic lung diseases such as asthma. However, it is unclear whether vitamin D is involved in disease pathogenesis or is modified by the inflammation associated with the disease process. We hypothesized that allergic inflammation decreases the level of circulating 25(OH)D and tested this using a mice model of house dust mite (HDM) induced allergic airway inflammation. Cellular influx was measured in bronchoalvelar lavage (BAL) fluid, and allergic sensitization and 25(OH)D levels were measured in serum. Exposure to HDM caused a robust inflammatory response in the lung that was enhanced by prior influenza infection. These responses were not associated with any change in circulating levels of 25(OH)D. These data suggest that alterations in circulating 25(OH)D levels induced by Th-2 driven inflammation are unlikely to explain the cross-sectional epidemiological association between vitamin D deficiency and asthma.