gebhart/patrepeval huggingface dataset:
Inhibition of HIV-1 Protease by a Boronic Acid with High Oxidative Stability (2023)

HIV-1 protease is an important target for pharmaceutical intervention in HIV infection. Extensive structure-based drug design led to darunavir becoming a key chemotherapeutic agent. We replaced the aniline group of darunavir with a benzoxaborolone to form BOL-darunavir. This analogue has the same potency as darunavir as an inhibitor of catalysis by wild-type HIV-1 protease and, unlike darunavir, does not lose potency as an inhibitor of the common D30N variant. Moreover, BOL-darunavir is much more stable to oxidation than is a simple phenylboronic acid analogue of darunavir. X-ray crystallography revealed an extensive network of hydrogen bonds between the enzyme and benzoxaborolone moiety, including a novel direct hydrogen bond from a main-chain nitrogen to the carbonyl oxygen of the benzoxaborolone moiety that displaces a water molecule. These data highlight the utility of benzoxaborolone as a pharmacophore.
A case-comparison study of the subdural evacuating port system in treating chronic subdural hematomas (2009)

The SEPS offers an alternative type of twist-drill craniostomy for the treatment of chronic SDH with a trend toward higher recurrence in our experience. The efficacy and safety of SEPS is similar to that of other twist-drill methods reported in the literature. In the authors' experience, the efficacy of this treatment as measured by radiographic worsening or the need for a subsequent procedure is statistically similar to that of bur hole treatment. There was no difference in mortality or other adverse outcomes associated with SEPS.
Use of recycled materials as mid layer in three layered structures-new possibility in design for recycling (2020)

Challenges of using recycled polymer materials in food packaging are related both to the properties of the material and demanding safety issues for food contact materials. The aim of this research was to detect possible risks using recycled post-consumer plastic waste in three-layered polyethylene (PE) films produced with virgin outer layers and a mid-layer from recycled flexible PE material. Migration tests were performed as risk assessment for identifying possible migrating substances from the mid-recycled layer. Overall migration was determined on various 3-layered structures made from virgin low-density PE (LDPE) and virgin linear low-density PE (LLDPE), respectively, with two different recycled PE from post-consumer waste (R1 and R2). 95% ethanol was used as a simulant for screening at 20, 40 and 60 °C for 10 days. Specific migration was performed using sophisticated analytical techniques (liquid and gas chromatography). Overall migration values for all temperatures were from < 2 mg/dm2 at lowest and 5.6 ± 0.1 mg/dm2 at highest temperature, thus well below the overall migration limit (OML) of 10 mg/dm2. Specific migration of intentionally and non-intentionally added substances were detected, identified and quantified. Similarly, specific migration values were under specific migration limit (SML) defined in legislation. Optical properties of the reference samples were significantly different in appearance and on cross section for samples with recycled materials R1 compared to recycled material R2 which caused only slight changes in the appearance of both reference films. This research presents a valuable study on migration from recycled flexible PE films and use of recycled materials in food packaging applications. Use of virgin materials as outer layer in combination with commercially available recycled material can increase the use of recycled materials in packaging as well as reduce the total amount of flexible plastic solid waste.
Sulfheme Proteins (1972)

Abstract The ferrous form of sulfmyoglobin was isolated as the first stable product of the reaction of a single mole of inorganic sulfide with 1 mole of the higher oxidation state derivative of myoglobin, Mbiv. Using radioactive sulfide, it was demonstrated that a single g atom of sulfur is incorporated per mole of myoglobin to form sulfmyoglobin. More than 85% of the radioactive sulfur is extracted into 2-butanone at pH 3.2, bound to the prosthetic group of sulfmyoglobin. The optical properties of the prosthetic group, which we call sulfhemin, and of some of its derivatives have been studied. Sulfhemin is unstable in organic solvents in the presence of O2 or peroxides and decomposes to yield protohemin in an autoxidative reaction which follows first order kinetics. Sulfate is the major sulfur compound ultimately produced in the decomposition of sulfhemin. Mercuric ion was also found to cause the decomposition of sulfhemin.
Enzymatic Modification of Plant Cell Wall Polysaccharides (2010)

Plant cell walls are intricate structures with remarkable properties, widely used in almost every aspect of our life. Cell walls consist largely of complex polysaccharides and there is often a need for chemical and biochemical processing before industrial use. There is an increasing demand for sustainable processes that replace chemical treatments with white biotechnology. Plants can contribute significantly to this sustainable process by producing plant or microbial enzymes in planta that are necessary for plant cell wall modification or total degradation. This will give rise to superior food fibres, hydrocolloids, paper, textile, animal feeds or biofuels. Classical microbial-based fermentation systems could in the future face serious competition from plant-based expression systems for enzyme production. Plant expressed enzymes can either be targeted to specific cellular compartments for accumulation and storage, or targeted to the cell wall for immediate modification of the polysaccharides. Furthermore, thermoactivated enzymes can successfully be employed to avoid undue degradation of the cell wall and detrimental phenotypes resulting from this. A further use of enzyme expression in planta is the possibility of elucidating the biological role of specific polymers, such as the involvement of xyloglucan in tree bending, or to decrease the level of pectin in flax to simplify the retting step in the textile refinery process.
Analog design challenges and trade-offs using emerging materials and devices (2007)

Analog device figures-of-merit change significantly with the introduction of advanced materials and devices such as high-k or Multiple-Gate FETs. Measurements show enhanced intrinsic gain and matching behavior for MuGFETs which help to reduce area and power consumption in analog circuits. However, high-k degrades matching, flicker noise and Vt stability. Measured device performance is used to simulate the impact of these trends on circuit design trade-offs. Migrating from SiON to HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> dielectric approximately doubles area and power consumption to keep matching and noise performance constant. Transient Vt instabilities in the range of 10 mV can degrade the resolution of analog-to-digital converters by more than one bit. The use of non-binary ADCs is proposed to overcome these issues.
The Facet Joint Loading Profile of a Cervical Intervertebral Disc Replacement Incorporating a Novel Saddle-shaped Articulation (2011)

Biomechanical testing in an ovine model demonstrated no significant difference in measured facet pressures and forces between an intact native cervical disc specimen and a cervical intervertebral disc prosthesis using a saddle-shaped articulation. Peak and mean pressures were not demonstrated to be significantly different between the implanted and intact disc conditions. Implantation of the prosthesis resulted in a significant reduction of contact area under extension moments.
564: Clinicians Can Accurately Select Patients in Whom Lymphadenectomy may be Safely Omitted at Radical Prostatectomy (2007)

You have accessJournal of UrologyModerated Poster 17, Sunday, May 20, 2007, 3:30 - 5:30 pm1 Apr 2007564: Clinicians Can Accurately Select Patients in Whom Lymphadenectomy may be Safely Omitted at Radical Prostatectomy Andrea Gallina, Jochen Walz, Georg C. Hutterer, Marco Raber, Sascha Ahyai, Eric A. Klein, Alwyn M. Reuther, James A. Eastham, Peter T. Scardino, Markus Graefen, Francesco Montorsi, Hartwig Huland, Fred Saad, and Pierre I. Karakiewicz Andrea GallinaAndrea Gallina More articles by this author , Jochen WalzJochen Walz More articles by this author , Georg C. HuttererGeorg C. Hutterer More articles by this author , Marco RaberMarco Raber More articles by this author , Sascha AhyaiSascha Ahyai More articles by this author , Eric A. KleinEric A. Klein More articles by this author , Alwyn M. ReutherAlwyn M. Reuther More articles by this author , James A. EasthamJames A. Eastham More articles by this author , Peter T. ScardinoPeter T. Scardino More articles by this author , Markus GraefenMarkus Graefen More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , Hartwig HulandHartwig Huland More articles by this author , Fred SaadFred Saad More articles by this author , and Pierre I. KarakiewiczPierre I. Karakiewicz More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)30804-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "564: Clinicians Can Accurately Select Patients in Whom Lymphadenectomy may be Safely Omitted at Radical Prostatectomy." The Journal of Urology, 177(4S), p. 188 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 188 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Andrea Gallina More articles by this author Jochen Walz More articles by this author Georg C. Hutterer More articles by this author Marco Raber More articles by this author Sascha Ahyai More articles by this author Eric A. Klein More articles by this author Alwyn M. Reuther More articles by this author James A. Eastham More articles by this author Peter T. Scardino More articles by this author Markus Graefen More articles by this author Francesco Montorsi More articles by this author Hartwig Huland More articles by this author Fred Saad More articles by this author Pierre I. Karakiewicz More articles by this author Expand All Advertisement Loading ...
Coherent Optical Signal Processing using Optical Frequency Combs and Injection Locked VCSELs (Invited) (2015)

Optical frequency combs are used as a set of mutually coherently orthogonal signals to realize high speed signal processing. Here, we demonstrate high speed sampling, arbitrary waveform generation and matched filtering functionality using frequency combs and vertical cavity surfacing emitting lasers as modulation elements for individual comb components.
Tetrodecamycin, a new antimicrobial antibiotic from Streptomyces. (1994)

A new antibiotic, aldecalmycin (1) was isolated from the culture broth of Streptomyces sp. MJ147-72F6. The 1H and 13C NMR spectra of 1 were complicated due to the presence of a β-ketoaldehyde moiety. Therefore, 1 was converted into an ethylene ketal derivative (2) and into a dihydroaldecalmycin (3). These derivatives gave assignable NMR spectra. The planar structure was elucidated by using 1H-1H COSY, 2D-HOHAHA, 1H-13C COSY and HMBC spectra of 2. The conformation of the decalin ring was elucidated by using 1D-HOHAHA, NOE difference and NOESY spectra of 3. The geometry of double bond in the side chain was determined by NOE difference and NOESY spectra of 3.
Abstract 634: Novel antibody-drug conjugates targeting Axl show anti-tumor activity in solid cancer xenograft models (2015)

Abstract Axl is a receptor tyrosine kinase of the TAM family, which is structurally characterized by the presence of two extracellular immunoglobulin-like domains and two fibronectin type III domains, a single-pass transmembrane region and an intracellular tyrosine kinase domain. Axl is aberrantly expressed and activated in both solid and hematological malignancies and has been associated with poor clinical prognosis in a number of cancers, including non-small cell lung cancer, breast cancer, pancreatic cancer and acute myeloid lymphoma. Functionally, Axl has been implicated in multiple pathological processes, such as tumor cell motility, adherence and migration, epithelial-to-mesenchymal transition, metastasis, angiogenesis and resistance to tyrosine kinase inhibitors. With the aim to target Axl expressing cancers, a panel of Axl-specific antibody-drug conjugates (ADC) was generated. First, high affinity human Axl antibodies were generated in HuMAb mice. Binding studies using Axl mutants, in which specific human Axl domains had been replaced with their murine analogs, demonstrated that the Axl antibody panel consisted of antibodies against different Axl extracellular domains. Second, the Axl antibodies were conjugated with the microtubule disrupting agent monomethyl auristatin E (MMAE) using the protease cleavable valine citrulline linker. Axl ADCs showed cytotoxic activity in vitro, which was dependent on target expression and on conjugation with cytotoxic payload. The anti-tumor activity of Axl ADCs was confirmed in vivo. Axl ADCs induced tumor regression in cell line derived xenograft models for lung cancer and epidermoid carcinoma. Anti-tumor activity was especially efficient in the lung cancer xenograft model, in which inhibition of tumor growth was observed upon treatment with a single dose of 0.5 mg/kg Axl ADC. In the same model, 1 mg/kg Axl ADC was sufficient to induce complete tumor regression. Importantly, Axl ADCs also showed efficient anti-tumor activity in patient-derived xenograft (PDX) models that showed heterogeneous target expression. In summary, Axl is a novel target for antibody-mediated delivery of cytotoxic agents into tumor cells. The promising results obtained in preclinical tumor models support further development of Axl-specific ADCs. Citation Format: Esther C.W. Breij, Sandra Verploegen, Andreas Lingnau, Edward N. van den Brink, Maarten Janmaat, Mischa Houtkamp, Wim K. Bleeker, David Satijn, Paul W.H.I. Parren. Novel antibody-drug conjugates targeting Axl show anti-tumor activity in solid cancer xenograft models. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 634. doi:10.1158/1538-7445.AM2015-634
Structure and stability of carboxylate complexes. Part IV. The crystal and molecular structure of sodium phenoxyacetate hemihydrate (1971)

The crystal and molecular structure of sodium phenoxyacetate hemihydrate (monoclinic, a= 6·22, b= 34·7, c= 7·88 Å, γ= 102·0°, space group A2/a) has been determined by three-dimensional X-ray techniques from photographic data by direct methods. The final refinement assumed anisotropic thermal vibration and the residual R was 0·096 for 1018 observed reflections. The crystals consist of sodium ions surrounded by distorted octahedra of oxygen atoms, five from four phenoxyacetate ions, and the sixth from a water molecule.
Supplementary Information Figure S3 from Dissecting Therapeutic Resistance to ERK Inhibition (2023)

&lt;p&gt;HTRF and Biacore binding data for active and inactive ERK1 in the presence of SCH772984&lt;/p&gt;
Optimal Spatiotemporal Focusing Through Multiple Scattering Media (2012)

International audience
Method and Apparatus for Simultaneous Stimulation of Multi-Well Pads (2009)

Abstract Progressively, the oil and gas industry is producing from unconventional reservoirs with low permeability in numerous small pay zones that require close well spacing and multiple stimulations in each well. To effectively produce from such reservoirs and reduce the surface footprint, ExxonMobil has drilled multiple wells from single pads, and new technologies have been developed to efficiently stimulate the multiple pay zones in each well. ExxonMobil has developed and licensed Multi-Zone Stimulation Technologies (MZST), which are designed to efficiently stimulate wells with multiple pays zones. The technologies have been applied in fracturing tight gas reservoirs with numerous lenticular sands in the Rocky Mountains. We have also developed a technology that enables the simultaneous stimulation of multiple wells on the same or different well pads, and while drilling additional wells. The benefits of this technology include reduced environmental impact, time saving, and improved production rates. Most importantly we have demonstrated that these simultaneous operations can be conducted in a safe and responsible manner to ensure the highest standards of operations integrity. This paper introduces the method and apparatus for this technology and discusses the results from several years of field applications, including the Piceance Basin. Some specific elements of the simultaneous operations safety plan will also be provided.
Nanoscale Stabilization of Sodium Oxides: Implications for Na–O2 Batteries (2014)

The thermodynamic stability of materials can depend on particle size due to the competition between surface and bulk energy. In this Letter, we show that, while sodium peroxide (Na2O2) is the stable bulk phase of Na in an oxygen environment at standard conditions, sodium superoxide (NaO2) is considerably more stable at the nanoscale. As a consequence, the superoxide requires a much lower nucleation energy than the peroxide, explaining why it can be observed as the discharge product in some Na-O2 batteries. As the superoxide can be recharged (decomposed) at much lower overpotentials than the peroxide, these findings are important to create highly reversible Na-O2 batteries. We derive the specific electrochemical conditions to nucleate and retain Na-superoxides and comment on the importance of considering the nanophase thermodynamics when optimizing an electrochemical system.
SFM study of the surface of halogen-bonded hybrid co-crystals containing long-chain perfluorocarbons (2008)

Different scanning force microscopy (SFM) techniques were employed to investigate the structure and composition of the fundamental crystal faces of prototype halogen-bonded co-crystals of long-chain perfluorocarbons. These crystals were found to show surfaces with well-defined ledges formed by intersecting crystal planes having different chemical compositions with the perfluorocarbons (PFCs) covering the largest area of the crystal as a reminiscence of the strong segregation observed in the bulk crystal structure.
Stereoselective total synthesis of ent-hyptenolide (2014)

A stereoselective total synthesis of <italic>ent</italic>-hyptenolide is reported.
High-Volume Hemofiltration (2001)

The use of continuous hemofiltration has increased dramatically since its first description in 1977. It is now the dominant form of renal replacement therapy in Australia and is fast reaching a similar status in many European countries. Its growing use and the frequent observation of its beneficial effects in septic patients has directed the attention of researchers toward its application in the field of blood purification for sepsis. In this context, experimental studies have suggested that increasing the volume of ultrafiltrate produced may increase the beneficial effects of continuous hemofiltration. This so-called high-volume hemofiltration (HVHF) has now been demonstrated to have striking beneficial effects on hemodynamics in porcine septic shock. It has also been shown to attenuate gastrointestinal mucosal reperfusion injury in a model of gut ischemia. Furthermore, the infusion of ultrafiltrate obtained during HVHF into healthy pigs induces profound hypotension and myocardial depression, suggesting that vasodilatory and myocardial depressant substances may be removed during the procedure. Such animal experiments have led clinicians to conduct their first interventions with HVHF in humans with the multi-organ dysfunction syndrome and septic shock. The initial results are promising. They open up a new area for the investigation of HVHF as an adjuvant therapy in the management of severe sepsis, septic shock, and the multi-organ dysfunction syndrome.
Feature Selection in Large Scale Data Stream for Credit Card Fraud Detection (2009)

There is increased interest in accurate model acquisition from large scale data streams. In this paper, because we have focused attention on time-oriented variation, we propose a method contracting time-series data for data stream. Additionally, our proposal method employs the combination of plural simple contraction method and original features. In this experiment, we treat a real data stream in credit card transactions because it is large scale and difficult to classify. This experiment yields that this proposal method improves classification performance according to training data. However, this proposal method needs more generality. Hence, we'll improve generality with employing the suitable combination of a contraction method and a feature for the feature in our proposal method.
1450-nm high-brightness wavelength-beam combined diode laser array (2008)

We have demonstrated wavelength beam combining of a 1450-nm diode laser array with a novel smile compensation method. We have achieved 20-W cw from a 25-element single bar with an M(2) of 1.9 (fast axis) x 10 (wavelength-beam-combined dimension).
Information rates of sampled Wiener processes (2016)

The minimal distortion attainable in recovering the waveform of a continuous-time Wiener process from an encoded version of its uniform samples is considered. We first introduce a combined sampling and source coding problem and prove an associated source coding theorem. We then derive an upper bound on the minimal distortion attainable under any sampling rate and a prescribed number of bits to encode the samples. We show that this bound is accurate to within a second order term in the sampling rate, and converges to the true distortion-rate function of the Wiener process as the sampling rate goes to infinity. For example, this bound implies that by providing a single bit per sample it is possible to achieve the optimal distortion-rate performance of the Wiener process, given by its distortion-rate function, to within a factor of 1.5. We conclude the distortion-rate function of the Wiener process is strictly smaller than the indirect distortion-rate function from its uniform samples obtained at any finite sampling rate. This is in contrast to stationary infinite bandwidth processes.
[Endocranial complications in otitis media: what you need to remember]. (2005)

Thanks to the potency of antibiotics, life-threatening complications of otitis media are rare. In many cases, however, the symptomatology is veiled, and the course of the disease tends to be protracted. Secondary symptoms may preponderate and often mask those associated with the ear itself. If a case of otitis media fails to clear up, or mastoiditis develops, or sensorineural deafness, vertigo, headaches, seizures, or meningism occur, the possibility of an otogenous complication must immediately be considered and the patient submitted to diagnostic imaging without delay, so as to ensure early surgical treatment of a possible lesion in the ear.