gebhart/patrepeval huggingface dataset:
Band-broadening phenomena in microcapillary tubes under the conditions of liquid chromatography (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBand-broadening phenomena in microcapillary tubes under the conditions of liquid chromatographyTakao. Tsuda and Milos. NovotnyCite this: Anal. Chem. 1978, 50, 4, 632–634Publication Date (Print):April 1, 1978Publication History Published online1 May 2002Published inissue 1 April 1978https://pubs.acs.org/doi/10.1021/ac50026a023https://doi.org/10.1021/ac50026a023research-articleACS PublicationsRequest reuse permissionsArticle Views296Altmetric-Citations110LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Correlation between heart valve interstitial cell stiffness and transvalvular pressure: implications for collagen biosynthesis (2005)

It has been speculated that heart valve interstitial cells (VICs) maintain valvular tissue homeostasis through regulated extracellular matrix (primarily collagen) biosynthesis. VICs appear to be phenotypically plastic, inasmuch as they transdifferentiate into myofibroblasts during valve development, disease, and remodeling. Under normal physiological conditions, transvalvular pressures (TVPs) on the right and left side of the heart are vastly different. Hence, we hypothesize that higher left-side TVPs impose larger local tissue stress on VICs, which increases their stiffness through cytoskeletal composition, and that this relation affects collagen biosynthesis. To evaluate this hypothesis, isolated ovine VICs from the four heart valves were subjected to micropipette aspiration to assess cellular stiffness, and cytoskeletal composition and collagen biosynthesis were quantified by using the surrogates smooth muscle alpha-actin (SMA) and heat shock protein 47 (HSP47), respectively. VICs from the aortic and mitral valves were significantly stiffer (P < 0.001) than those from the pulmonary and tricuspid valves. Left-side isolated VICs contained significantly more (P < 0.001) SMA and HSP47 than right-side VICs. Mean VIC stiffness correlated well (r = 0.973) with TVP; SMA and HSP47 also correlated well (r = 0.996) with one another. Assays were repeated for VICs in situ, and, as with in vitro results, left-side VIC protein levels were significantly greater (P < 0.05). These findings suggest that VICs respond to local tissue stress by altering cellular stiffness (through SMA content) and collagen biosynthesis. This functional VIC stress-dependent biosynthetic relation may be crucial in maintaining valvular tissue homeostasis and also prove useful in understanding valvular pathologies.
Supplementary Figure S1 from Circulating Cell-Free DNA to Guide Prostate Cancer Treatment with PARP Inhibition (2023)

&lt;p&gt;Consort diagram describing samples disposition in the study.&lt;/p&gt;
High-througput and low-cost nanophotonic based diagnostics technologies (2013)

We present a high-throughput label-free protein microarray technology using large-area plasmonic nanohole arrays. Our detection principle is based on multi-spectral on-chip imaging enabling quantitative, realtime and high-throughput detection. We use low-cost and large area nanofabrication methods for manufacturing of plasmonic nanostructures with high optical qualities. Our system could become a powerful tool for biomedical sciences and pharmacology.
Design of triphasic poly(lactic-co-glycolic acid) nanoparticles containing a perfluorocarbon phase for biomedical applications (2018)

Poly(lactic-<i>co</i>-glycolic acid) (PLGA) particles are very widely used, particularly for drug delivery, including commercial clinical formulations. Adding perfluorocarbon (PFC) enables <i>in vivo</i> imaging and quantification of the PLGA particles through <sup>19</sup>F NMR, MRS or MRI. PFCs are both hydrophobic and lipophobic at the same time. This property makes their encapsulation in particles challenging, as it requires the addition of a third immiscible phase during the emulsification process. Here we explore how different parameters affect the miniemulsion formation of particles loaded with perfluoro-15-crown-5-ether (PFCE). By changing the concentration of surfactant and type of solvent, we were able to control the radius of synthesized particles, between 85-200 nm. We assessed stability and release from the particles at different pH values, showing that hydrophobic agents are released from the particles by diffusion rather than degradation. With cell experiments, we show that primary human dendritic cells take up the particles without any apparent effect, including on cell migration. In summary, the control of synthesis conditions leads to particles with sufficient PFCE encapsulation, which are suitable for drug loading and cell labeling, and do not affect cell viability or functionality. Finally, these nanoparticles can be produced at GMP-grade for clinical use.
Hybrid precoding for mmWave massive MIMO systems with generalized triangular decomposition (2018)

Hybrid precoding schemes have recently gained a great attention for millimeter wave (mmWave) massive multiple-input-multiple-output (massive MIMO) communication systems because of offered cost and low-power consumption advantages. The singular value decomposition (SVD) method which is exploited in the design of hybrid precoding causes several problems on system design, especially on bit allocation, precoding and equalizing processes. On the other hand, the previous works show that generalized triangular decomposition (GTD) method can present asymptotically optimal performance in conventional MIMO systems. In the light of this, we propose the use of GTD method for designing hybrid precoding operating in mmWave massive MIMO systems. The proposed design is analyzed via performed simulation studies including different system configurations. Moreover, the archived results are compared with the standard orthogonal matching pursuit (OMP) algorithm based hybrid precoding scheme. The simulation results show that the proposed hybrid precoding scheme can reach up to the performance of optimal precoding scheme.
Geodesic Atlas-Based Labeling of Anatomical Trees: Application and Evaluation on Airways Extracted From CT (2014)

We present a fast and robust atlas-based algorithm for labeling airway trees, using geodesic distances in a geometric tree-space. Possible branch label configurations for an unlabeled airway tree are evaluated using distances to a training set of labeled airway trees. In tree-space, airway tree topology and geometry change continuously, giving a natural automatic handling of anatomical differences and noise. A hierarchical approach makes the algorithm efficient, assigning labels from the trachea and downwards. Only the airway centerline tree is used, which is relatively unaffected by pathology. The algorithm is evaluated on 80 segmented airway trees from 40 subjects at two time points, labeled by three medical experts each, testing accuracy, reproducibility and robustness in patients with chronic obstructive pulmonary disease (COPD). The accuracy of the algorithm is statistically similar to that of the experts and not significantly correlated with COPD severity. The reproducibility of the algorithm is significantly better than that of the experts, and negatively correlated with COPD severity. Evaluation of the algorithm on a longitudinal set of 8724 trees from a lung cancer screening trial shows that the algorithm can be used in large scale studies with high reproducibility, and that the negative correlation of reproducibility with COPD severity can be explained by missing branches, for instance due to segmentation problems in COPD patients. We conclude that the algorithm is robust to COPD severity given equally complete airway trees, and comparable in performance to that of experts in pulmonary medicine, emphasizing the suitability of the labeling algorithm for clinical use.
Crystallographic Analysis of the Human Phenylalanine Hydroxylase Catalytic Domain with Bound Catechol Inhibitors at 2.0 Å Resolution, (1998)

The aromatic amino acid hydroxylases represent a superfamily of structurally and functionally closely related enzymes, one of those functions being reversible inhibition by catechol derivatives. Here we present the crystal structure of the dimeric catalytic domain (residues 117-424) of human phenylalanine hydroxylase (hPheOH), cocrystallized with various potent and well-known catechol inhibitors and refined at a resolution of 2.0 A. The catechols bind by bidentate coordination to each iron in both subunits of the dimer through the catechol hydroxyl groups, forming a blue-green colored ligand-to-metal charge-transfer complex. In addition, Glu330 and Tyr325 are identified as determinant residues in the recognition of the inhibitors. In particular, the interaction with Glu330 conforms to the structural explanation for the pH dependence of catecholamine binding to PheOH, with a pKa value of 5.1 (20 degreesC). The overall structure of the catechol-bound enzyme is very similar to that of the uncomplexed enzyme (rms difference of 0.2 A for the Calpha atoms). Most striking is the replacement of two iron-bound water molecules with catechol hydroxyl groups. This change is consistent with a change in the ligand field symmetry of the high-spin (S = 5/2) Fe(III) from a rhombic to a nearly axial ligand field symmetry as seen upon noradrenaline binding using EPR spectroscopy [Martinez, A., Andersson, K. K., Haavik, J., and Flatmark, T. (1991) Eur. J. Biochem. 198, 675-682]. Crystallographic comparison with the structurally related rat tyrosine hydroxylase binary complex with the oxidized cofactor 7,8-dihydrobiopterin revealed overlapping binding sites for the catechols and the cofactor, compatible with a competitive type of inhibition of the catechols versus BH4. The comparison demonstrates some structural differences at the active site as the potential basis for the different substrate specificity of the two enzymes.
Search for heavy Majorana neutrinos with the ATLAS detector in pp collisions at $$ \sqrt{s}=8 $$ TeV (2015)

A bstract A search for heavy Majorana neutrinos in events containing a pair of high- p T leptons of the same charge and high- p T jets is presented. The search uses 20.3 fb −1 of pp collision data collected with the ATLAS detector at the CERN Large Hadron Collider with a centre-of-mass energy of $$ \sqrt{s}=8 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>8</mml:mn> </mml:math> TeV. The data are found to be consistent with the background-only hypothesis based on the Standard Model expectation. In the context of a Type-I seesaw mechanism, limits are set on the production cross-section times branching ratio for production of heavy Majorana neutrinos in the mass range between 100 and 500 GeV. The limits are subsequently interpreted as limits on the mixing between the heavy Majorana neutrinos and the Standard Model neutrinos. In the context of a left-right symmetric model, limits on the production cross-section times branching ratio are set with respect to the masses of heavy Majorana neutrinos and heavy gauge bosons W R and Z ′.
Towards Formal Analysis of the Permission-Based Security Model for Android (2009)

Since the source code of Android was released to the public, people have concerned about the security of the Android system. Whereas the insecurity of a system can be easily exaggerated even with few minor vulnerabilities, the security is not easily demonstrated. Formal methods have been favorably applied for the purpose of ensuring security in different contexts to attest whether the system meets the security goals or not by relying on mathematical proofs. In order to commence the security analysis of Android, we specify the permission mechanism for the system. We represent the system in terms of a state machine, elucidate the security needs, and show that the specified system is secure over the specified states and transitions. We expect that this work will provide the basis for assuring the security of the Android system. The specification and verification were carried out using the Coq proof assistant.
p-n junctions on Ga-face GaN grown by NH3 molecular beam epitaxy with low ideality factors and low reverse currents (2010)

A comprehensive analysis of forward and reverse current of Ga-face GaN p-n junctions grown by NH3 molecular beam epitaxy (NH3-MBE) on metal organic chemical vapor deposition (MOCVD) GaN:Fe on sapphire is presented. NH3-MBE has a great potential for growing low leakage vertical devices due to its nitrogen-rich growth. Diodes with the lowest n-doping of n∼3.5×1017 cm−3 exhibit an extremely low reverse current of 2.6×10−7 A/cm2 at −40 V and an ideality factor of 1.3, which is lower than the state-of-the-art Ga-face p-n junctions grown on sapphire by MOCVD. An explanation for the difficulty for observing low ideality factors in GaN is presented.
Arrayed Microchannel Manufacturing Costs for an Auxiliary Power Unit Heat Exchanger (2011)

Chemical and energy conversion systems based on microchannel process technology demonstrate high performance in applications in which rates are controlled by diffusive heat and mass transfer flux. The accelerated heat and mass transfer intensifies the process leading to smaller unit operations used in a variety of mobile energy conversion systems including fuel reformers/converters, heat pumps and waste heat scavenging technologies. Fabrication of these microchannel unit operations has historically been performed using a stacked-shim approach in which individual metal sheets are first patterned with micro- and meso-scale flow channels and subsequently bonded in a stack to create a two-dimensional array of parallel microchannel flow paths. Recent work at the Microproducts Breakthrough Institute has focused on exploring the cost of goods sold and capital investment required for high volume manufacturing of MPT devices using process-based cost models developed in collaboration with industry partners. Here, a process-based cost model is presented showing the capital investment and cost-of-goods-sold as a function of annual production volume for a stainless steel heat exchanger designed, built and tested by Pacific Northwest National Laboratory, with potential applications in military markets. In this paper we present results and analysis of the cost modeling effort to date.
ChemInform auf CD‐ROM (1997)

Abstract ChemInform ist ein hochwertiges Referateorgan für präparativ arbeitende Chemiker, das auch Reaktionsschemata und Formelzeichnungen bei einem Großteil der zusammengefaßten Artikel bietet. Die CD‐ROM‐Version mit ihrer komfortablen Such‐ und Verwaltungsoberfläche bringt seine Qualitäten erst richtig zur Geltung.
Freeform 3D Ice Printing (3D‐ICE) at the Micro Scale (2022)

Water is one of the most important elements for life on earth. Water's rapid phase-change ability along with its environmental and biological compatibility also makes it a unique structural material for 3D printing of ice structures reproducibly and accurately. This work introduces the freeform 3D ice printing (3D-ICE) process for high-speed and reproducible fabrication of ice structures with micro-scale resolution. Drop-on-demand deposition of water onto a -35 °C platform rapidly transforms water into ice. The dimension and geometry of the structures are critically controlled by droplet ejection frequency modulation and stage motions. The freeform approach obviates layer-by-layer construction and support structures, even for overhang geometries. Complex and overhang geometries, branched hierarchical structures with smooth transitions, circular cross-sections, smooth surfaces, and micro-scale features (as small as 50 µm) are demonstrated. As a sample application, the ice templates are used as sacrificial geometries to produce resin parts with well-defined internal features. This approach could bring exciting opportunities for microfluidics, biomedical devices, soft electronics, and art.
A Single-Staged PV Array-Based High-Frequency Link Inverter Design with Grid Connection (2006)

This paper proposes an efficient control approach of photovoltaic (PV) array-based high-frequency link inverter architecture that tracks the maximum available power of a PV array source and synchronously supplies sinusoidal current into the utility grid by using only a single stage of power processing conversion. A feed-forward compensator eliminates the loop gain dependence on the utility grid and keep the input maximum power of PV array during variable grid voltage. Voltage seconds analysis shows that the transformer can be designed as the conventional high-frequency transformer of a DC/DC converter without any low frequency harmonics. Simulation and experimental results show that the full-bridge switches are turning on at zero voltage.
<title>CO2 laser tailored blank welding: process monitoring</title> (1996)

Tailored blank welding has been a rapidly growing segment of the automotive industry over the last five years. It allows to choose the optimal thickness of the sheets for different zones taking into account different mechanical stresses, vehicle safety reinforcement. Through the elimination of extra reinforcement parts, the use of tailored blanks allows to produce lighter car bodies and to simplify the production cycle. As more laser welding systems are being installed in industry, in order to increase the productivity and maintain constant quality of the products, the demand for the development of process monitoring systems increases. In this paper a monitoring system, based on the measurement of the radiation from the plasma plume during the CO<SUB>2</SUB> tailored blanks laser welding, is presented. Using an appropriate combination of optical components, detectors and a special software, a complete apparatus has been developed. The signals were found to be correlated to weld quality parameters including the defects such as holes, overlapping and open butts.
Robust and Gain Scheduled H∞ Controllers for Lateral Guidance of Passenger Vehicles in AHS (1997)

Abstract This paper presents two lateral control designs for passenger vehicles in the Automated Highway System (AHS). The control designs are a natural combination of input-output linearization technique and the H∞ control design techniques. Input-output linearization in the context of steering angle as the input and lateral error at a certain point on the vehicle as the output is the first design step. Even though this form is amenable to robust control techniques such as the Sliding Mode Control, there is insufficient, damping of the yaw dynamics, especially at high longitudinal velocities. The damping of the yaw dynamics is improved by adding an outer feed back loop based on the H∞ control techniques.
Engineering cross-presentation in vivo (2003)

Apoptotic bodies deliver antigens (Ags) to the cross-presentation pathways of dendritic cells (DCs), where their presentation has been associated with both the maintenance of tolerance as well as the induction of protective immunity. The manner in which apoptotic bodies are generated, their abundance in relation to local DCs, and the milieu in which they are generated appear to be the major factors determining whether apoptotic bodies will induce CD8+ T cell activation or anergy. These observations have been extended to the field of vaccination, where the engineered apoptosis of Ag-bearing/loaded cells in vivo has been used to prime strong CD8+ T cell immunity. This review will examine Ag capture and cross-presentation by DCs, with particular emphasis on the manipulation of apoptotic bodies in vivo for the purpose of vaccination.
An implementation friendly low complexity multiplierless LLR generator for soft MIMO sphere decoders (2008)

When combined with advanced FEC techniques such as the Turbo code and LDPC code, soft-output MIMO sphere decoders significantly outperform hard-output sphere decoders. Hence, algorithms and implementations of soft-output sphere decoders have attracted intensive interest in recent years. Practical soft-output sphere decoder implementations often consist of a list generator and a LLR generator. Most existing implementations focus on the list generator, and the LLR generator is implemented in a relatively straightforward way. However, the LLR generator accounts for a great part of the complexity. Our contribution is an implementation friendly low complexity multiplierless LLR generator. We apply selective and incremental updating, algebraic simplifications and strength reductions to reduce the algorithmic complexity and to eliminate all multiplications. When integrated with the SSFE list generator, our scheme not only remove 100% multiplications, but also remove 26% to 83% additions, 76% to 94% bit-shifts and 63% to 91% memory operations. Besides the algorithmic aspects, we extract the key data-flow block with well-defined control signals. This can be easily mapped onto micro-architectures and implemented as the data-path in ASICs, or a function unit in ASIPs.
Coupled Microcavities in Light-Emitting Porous Silicon (1998)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text P. A. Snow, E. K. Squire, P.St.J. Russell, L. T. Canham, A. J. Simons, and C. L. Reeves, "Coupled Microcavities in Light-Emitting Porous Silicon," Optics & Photonics News 9(12), 27-28 (1998) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Efficient hydration of alkynes through acid-assisted Brønsted acid catalysis (2014)

The combined acid catalyzed hydration of alkynes is an efficient one-step synthesis of carbonyl compounds. This atom-economical method is effective with a wide range of substrates, and the products are obtained in very good yields with low catalyst loading (0.2%). Furthermore, solid acids like Nafion were also efficient and could be easily recycled multiple times without loss of reactivity.