gebhart/patrepeval huggingface dataset:
No-Reference Bitstream-Based Visual Quality Impairment Detection for High Definition H.264/AVC Encoded Video Sequences (2012)

Ensuring and maintaining adequate Quality of Experience towards end-users are key objectives for video service providers, not only for increasing customer satisfaction but also as service differentiator. However, in the case of High Definition video streaming over IP-based networks, network impairments such as packet loss can severely degrade the perceived visual quality. Several standard organizations have established a minimum set of performance objectives which should be achieved for obtaining satisfactory quality. Therefore, video service providers should continuously monitor the network and the quality of the received video streams in order to detect visual degradations. Objective video quality metrics enable automatic measurement of perceived quality. Unfortunately, the most reliable metrics require access to both the original and the received video streams which makes them inappropriate for real-time monitoring. In this article, we present a novel no-reference bitstream-based visual quality impairment detector which enables real-time detection of visual degradations caused by network impairments. By only incorporating information extracted from the encoded bitstream, network impairments are classified as visible or invisible to the end-user. Our results show that impairment visibility can be classified with a high accuracy which enables real-time validation of the existing performance objectives.
Cycle-to-Cycle Feedback for Combustion Control of Spark Advance at the Misfire Limit (2018)

At a given speed and load, the spark advance (SA) is tuned to reach the maximum brake torque (MBT) timing to maximize efficiency. The use of exhaust gas recirculation (EGR) can further improve fuel economy (FE) at the same speed and load. As EGR increases, MBT moves toward a more advanced timing that can be limited by the high variability in the combustion process, reflected in unacceptable torque fluctuations. This variability is rapidly increased by the random occurrence of partial burns and/or misfires. In order to operate close to the misfire limit, a stochastic misfire controller has been designed to momentarily move from an undesired to an allowable misfire rate, without significantly increasing variability in the combustion process. Control-oriented models for the combustion process and misfire events are discussed. Simulation of the closed-loop system shows that the feedback misfire controller, on average, stays closer to the misfire limit than a more conventional controller designed to react when a misfire is detected.
Testing of Experimental Compounds in a Relapse Model of Tuberculosis Using Granulocyte-Macrophage Colony-Stimulating Factor Gene-Disrupted Mice (2008)

This study describes an in vivo model for evaluating the sterilizing activity of compounds against persisting Mycobacterium tuberculosis. The initial treatment with isoniazid and rifampin in granulocyte-macrophage colony-stimulating factor gene-disrupted mice reduced the number of bacteria more than 99% within 3 weeks. A subsequent treatment with individual drugs was performed to assess their activity on the 1% of remaining bacilli and disease relapse.
Age-associated increased inflammatory response to pulmonary bacterial challenge (2009)

Introduction Urokinase receptor (uPAR, CD87), a glycosylphosphatidylinositol-anchored protein, is considered to play an important role in inflammation and fibrinolysis. The Gram-negative bacterium Burkholderia pseudomallei is able to survive and replicate within leukocytes and causes melioidosis, an important cause of pneumonia-derived community-acquired sepsis in Southeast Asia. We here investigated the expression and function of uPAR both in patients with septic melioidosis and in a murine model of experimental melioidosis. Methods Using a translational approach we conducted a patient study in patients with culture-confirmed sepsis caused by B. pseudomallei, in vitro experiments using wild-type (WT) and uPAR knockout (KO) cells, and mouse studies using WT and uPAR KO mice inoculated with B. pseudomallei. Results uPAR mRNA and surface expression was increased in patients with septic melioidosis in/on both peripheral blood monocytes and granulocytes as well as in the pulmonary compartment during experimental pneumonia-derived melioidosis in mice. uPAR-deficient mice intranasally infected with B. pseudomallei showed an enhanced growth and dissemination of B. pseudomallei when compared with WT mice, corresponding with increased pulmonary and hepatic inflammation. uPAR KO mice demonstrated significantly reduced neutrophil migration towards the pulmonary compartment after inoculation with B. pseudomallei. Further in vitro experiments showed that uPARdeficient macrophages and granulocytes display a markedly impaired phagocytosis of B. pseudomallei. Additional studies showed that uPAR deficiency did not influence hemostatic and fibrinolytic responses during severe melioidosis. Conclusions These data suggest that uPAR is crucially involved in the host defense against sepsis caused by B. pseudomallei by facilitating the migration of neutrophils towards the primary site of infection and subsequently facilitating the phagocytosis of B. pseudomallei. P2 A comparison of acute lung inflammation in Klebsiella pneumoniae B5055-induced pneumonia and sepsis in BALB/c mice
Downlink transmission timing shift in mobile fronthaul for TDD radio access network (2014)

We propose a downlink transmission timing shift in the fronthaul that advances the downlink transmission timing in order to improve the frame efficiency for time-division duplex radio access network in the centralized radio access network architecture. Numerical results show that the proposed technique provides high frame efficiency regardless of the optical transmission length in the fronthaul.
Supplementary Methods and Figure legends from Extracellular-Regulated Protein Kinase 5-Mediated Control of p21 Expression Promotes Macrophage Proliferation Associated with Tumor Growth and Metastasis (2023)

&lt;p&gt;This file contains Supplementary Methods for i) isolating single cells from murine tumors and lungs, ii) magnetic bead purification of tumor-associated macrophages and monocytes, and iii) EdU labelling and staining; and Supplementary legends for Figures S1 to S13.&lt;/p&gt;
Laser photoionization and light-initiated redox reactions of tetramethylbenzidine in organic solvents and aqueous micellar solution (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLaser photoionization and light-initiated redox reactions of tetramethylbenzidine in organic solvents and aqueous micellar solutionS. A. Alkaitis and M. GraetzelCite this: J. Am. Chem. Soc. 1976, 98, 12, 3549–3554Publication Date (Print):June 1, 1976Publication History Published online1 May 2002Published inissue 1 June 1976https://pubs.acs.org/doi/10.1021/ja00428a027https://doi.org/10.1021/ja00428a027research-articleACS PublicationsRequest reuse permissionsArticle Views263Altmetric-Citations101LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Spatial coefficient of variation in pseudo-continuous arterial spin labeling cerebral blood flow images as a hemodynamic measure for cerebrovascular steno-occlusive disease: A comparative 15O positron emission tomography study (2018)

Pseudo-continuous arterial spin labeling (pCASL) is a completely non-invasive method of cerebral perfusion measurement. However, cerebral blood flow (CBF) quantification is hampered by arterial transit artifacts characterized by bright vascular signals surrounded by decreased signals in tissue regions, which commonly appear in patients with reduced cerebral perfusion pressure. The spatial coefficient of variation (CoV) of pCASL CBF images has been proposed as an alternative region-of-interest (ROI)-based hemodynamic measure to predict prolonged arterial transit time (ATT). This retrospective study investigates the utility of spatial CoV by comparison with <sup>15</sup>O positron emission tomography (PET). For patients with cerebrovascular steno-occlusive disease ( n = 17), spatial CoV was positively correlated with ATT independently measured by pulsed arterial spin labeling ( r = 0.597, p < 0.001), confirming its role as an ATT-like hemodynamic measure. Comparisons with <sup>15</sup>O PET demonstrated that spatial CoV was positively correlated with vascular mean transit time ( r = 0.587, p < 0.001) and negatively correlated with both resting CBF ( r = -0.541, p = 0.001) and CBF response to hypercapnia ( r = -0.373, p = 0.030). ROI-based spatial CoV calculated from single time-point pCASL can potentially detect subtle perfusion abnormalities in clinical settings.
The Effect of Free Surface on the Vortex Shedding From Inclined Circular Cylinders (2008)

Spectral analysis of laser Doppler velocimetry measurements and flow visualization are employed to study the wake of inclined cylinders piercing a free surface. The results indicate that the free surface affects vortex shedding almost two to three cylinder diameters below the free surface. Variation of the vortex axis inclination and cells of shedding were visually observed. These effects induce a phase difference in the vortex-shedding mechanism. Streamwise vortical structures are formed along the primary vortex axis. Furthermore, for the case of the highest Froude number, evidence is provided that vortex shedding is suppressed in the region near the free surface.
Boundary-layer analysis of a spiral wave core: Spiral core radius and conditions for the tip separation from the core boundary (1997)

The size of a spiral core is predicted on the basis of a boundary-layer analysis of a spiral tip in the nonkinematic limit. Dependencies of a spiral core radius on medium parameters are found analytically and numerically for two models of excitable media. It is shown that the core radius is determined by the conditions for the tip separation from a core boundary. It is found that a core radius depends on all currents that are active during a wave front formation associated with the diffusion fluxes coupling neighboring elements of excitable media. Varying currents that activated only after wave front formation do not result in a significant altering of a spiral core radius.
Assist-as-Needed Robot-Aided Gait Training Improves Walking Function in Individuals Following Stroke (2015)

A novel robot-aided assist-as-needed gait training paradigm has been developed recently. This paradigm encourages subjects' active participation during training. Previous pilot studies demonstrated that assist-as-needed robot-aided gait training (RAGT) improves treadmill walking performance post-stroke. However, it is not known if there is an over-ground transfer of the training effects from RAGT on treadmill or long-term retention of the effects. The purpose of the current study was to examine the effects of assist-as-needed RAGT on over-ground walking pattern post-stroke. Nine stroke subjects received RAGT with visual feedback of each subject's instantaneous ankle malleolus position relative to a target template for 15 40-minute sessions. Clinical evaluations and gait analyses were performed before, immediately after, and 6 months post-training. Stroke subjects demonstrated significant improvements and some long-term retention of the improvements in their self-selected over-ground walking speed, Dynamic Gait Index, Timed Up and Go, peak knee flexion angle during swing phase and total hip joint excursion over the whole gait cycle for their affected leg . These preliminary results demonstrate that subjects improved their over-ground walking pattern and some clinical gait measures post-training suggesting that assist-as-needed RAGT including visual feedback may be an effective approach to improve over-ground walking pattern post-stroke.
Supplementary Movie S2 from Differential Expression of CD49a and CD49b Determines Localization and Function of Tumor-Infiltrating CD8<sup>+</sup> T Cells (2023)

&lt;p&gt;Movement of cells in anti-CD49b treated tumor slices&lt;/p&gt;
PyRanges: efficient comparison of genomic intervals in Python (2019)

Abstract Summary Complex genomic analyses often use sequences of simple set operations like intersection, overlap, and nearest on genomic intervals. These operations, coupled with some custom programming, allow a wide range of analyses to be performed. To this end, we have written PyRanges, a data structure for representing and manipulating genomic intervals and their associated data in Python. Run single-threaded on binary set operations, PyRanges is in median 2.3-9.6 times faster than the popular R GenomicRanges library and is equally memory efficient; run multi-threaded on 8 cores, our library is up to 123 times faster. PyRanges is therefore ideally suited both for individual analyses and as a foundation for future genomic libraries in Python. Availability PyRanges is available open-source under the MIT license at https://github.com/biocore-NTNU/pyranges and documentation exists at https://biocore-NTNU.github.io/pyranges/ Contact endrebak85@gmail.com Supplementary information Supplementary data are available.
A drug interaction study between ketoconazole and panobinostat (LBH589), an orally active histone deacetylase inhibitor, in patients with advanced cancer (2009)

2501 Background: The effects of ketoconazole (keto), a potent CYP3A inhibitor, on the pharmacokinetics (PK) of panobinostat (PAN) were investigated in an open-label, multicenter, cross-over, single sequence study. Methods: Patients (pts) with advanced solid tumors or NHL received single-agent PAN at 20 mg on Day 1 and single-agent keto at 400 mg daily on Days 5–9. On Day 8, PAN 20 mg was administered 1 hour after keto. All pts had adequate organ function and ECOG performance status &lt;2. Serial plasma samples were collected for PAN PK evaluations on Days 1 and 8 and pre- and post-dose keto samples on Days 5, 8, and 9. Plasma PAN and keto concentrations were measured by LC-MS-MS. PK parameters were estimated by using non-compartmental analysis. Genotyping analysis of CYP3A4*1B, CYP3A5*2, *3, *6 and *7 were performed by using AmpliChip CYP450. Results: Fourteen Caucasian patients (9M, 5F) were enrolled with a median age of 59. Fourteen pts had homozygous wide-type CYP3A4*1A genotype, 11 pts had homozygous CYP3A5*3, and three pts had heterozygous CYP3A5*1/*3 genotype. No residual PAN concentrations were detected in pre-dose samples on Day 8. PAN PK parameters were calculated as either mean (CV%), median [range] or ratio (see Table). Single-dose PAN did not affect keto concentrations. Co-administration of keto and PAN increased PAN C max and AUC by 1.6- and 1.7-fold, respectively, but with no change in T max . There was no apparent difference in PAN PK between pts who carried CYP3A5*1 allele and homozygous CYP3A5*3 carriers. Conclusions: The less than 2-fold increase in PAN AUC upon co-administration suggests that CYP3A contribution to the total clearance of PAN is low. The observed interaction is not considered clinically relevant, as PAN doses are at least 2-fold greater than 20 mg (40 and 60 mg) have been safely administered in pts. CYP3A4 inhibitors should have no major impact on the exposure of PAN and may be co-administered when medically necessary. [Table: see text] [Table: see text]
Differential Functions of Splicing Factors in Mammary Transformation and Breast Cancer Metastasis (2019)

Misregulation of alternative splicing is a hallmark of human tumors, yet to what extent and how it contributes to malignancy are only beginning to be unraveled. Here, we define which members of the splicing factor SR and SR-like families contribute to breast cancer and uncover differences and redundancies in their targets and biological functions. We identify splicing factors frequently altered in human breast tumors and assay their oncogenic functions using breast organoid models. We demonstrate that not all splicing factors affect mammary tumorigenesis in MCF-10A cells. Specifically, the upregulation of SRSF4, SRSF6, or TRA2β disrupts acinar morphogenesis and promotes cell proliferation and invasion in MCF-10A cells. By characterizing the targets of these oncogenic splicing factors, we identify shared spliced isoforms associated with well-established cancer hallmarks. Finally, we demonstrate that TRA2β is regulated by the MYC oncogene, plays a role in metastasis maintenance in vivo, and its levels correlate with breast cancer patient survival.
Review of Scientific Self-Experimentation: Ethics History, Regulation, Scenarios, and Views Among Ethics Committees and Prominent Scientists (2018)

We examine self-experimentation ethics history and practice, related law, use scenarios in universities and industry, and attitudes. We show through analysis of the historical development of medical ethics and regulation, from Hippocrates through Good Clinical Practice that there are no ethical barriers to self-experimentation. When the self-experimenter is a true investigator, there is no other party to be protected from unethical behavior. We discuss the n-of-1 issue in self-experiments, and make suggestions for improving experiment design. We discuss real-world scenarios of self-experimentation: at universities, for independent single-subject investigators, investigator/employees at pharmaceutical firms, and nonscientist self-experimenters. Our survey of ethics committees regarding policy and review for self-experimenting investigators show that approximately one-third of ethics committee respondents had a policy regarding self-experimentation, and one-third did not require ethical committee review of proposed experiments. There was no relationship between having a policy and asking for review. We also surveyed member attitudes to, and experiences of, self-experimentation among members of the National Academy of Sciences, Royal Society, and European Academy of Sciences. To our knowledge, this survey is the first breakdown of self-experiments into impact-relevant type classifications, and represents an advance in the field. Half of our scientist respondents performed self-experiments, and roughly one-fifth had conducted serious self-experiments. Most responders thought self-experiments were valuable, however, biologics injections, radiation exposure, and surgical implants had negative ratings greater than positive. We conclude that self-experimenters should not have attempts made to terminate them, bar them from use of facilities, nor be barred from using themselves or their tissues except in exceptional circumstances. Organizational uncertainty over the ethical and regulatory status of self-experimentation, and resulting fear of consequences is unjustified and may be blocking a route to human experiments that practicing scientists widely consider appropriate, and which historical precedent has shown is valuable.
Engineering ethical behaviors in autonomous industrial cyber-physical human systems (2021)

Abstract This paper addresses the engineering of the ethical behaviors of autonomous industrial cyber-physical human systems in the context of Industry 4.0. An ethical controller is proposed to be embedded into these autonomous systems, to enable their successful integration in the society and its norms. This proposed controller that integrates machine ethics is realized through three main strategies that utilize two ethical paradigms, namely deontology, and consequentialism. These strategies are triggered according to the type of event sensed and the state of the autonomous industrial cyber-physical human systems, their combination being potentially unknown or posing ethical dilemmas. Two case studies are investigated, that deal with a fire emergency, and two different contexts i.e. one with an autonomous train, and one with an autonomous industrial plant, are discussed to illustrate the controller utilization. The case studies demonstrate the potential benefits and exemplify the need to integrate ethical behaviors in autonomous industrial cyber-physical human systems already at the design phase. The proposed approach, use cases, and discussions make evident the need to address ethical aspects in new efforts to engineer industrial systems in the context of Industry 4.0.
Frontiers in Science: Protecting the power grid with physics [Slides] (2021)

Abstract not provided.
Novel technique for measuring through-plane modulus in thin polymer films (2002)

Polymer thin films are widely used as coatings and inter-level dielectrics in microelectronic applications. In multi-layer structures, stresses generated in the films due to interaction with adjacent layers and solvent evaporation induced shrinkage, cause the polymer chains to orient in the plane of the film resulting in anisotropic film properties. Characterization of properties in all directions is essential for accurate electrical and mechanical design and modeling. A new technique has been developed to measure, in situ, the through-plane (z) stress-strain behavior of thin polymer films. A parallel plate capacitor device and an interdigitated electrode structure were used as sensors to detect changes in dielectric constant and thickness of thin polymer films under compression. Results are reported for 8-14 micrometer thick, Dow Chemical Cyclotene 3022 benzocyclobutene (BCB) films. The dielectric constant was found to change linearly with stress. Using this result, the through-plane stress-strain curve was obtained and the modulus estimated.
Precise interprocedural analysis using random interpretation (2005)

We describe a unified framework for random interpretation that generalizes previous randomized intraprocedural analyses, and also extends naturally to efficient interprocedural analyses. There is no such natural extension known for deterministic algorithms. We present a general technique for extending any intraprocedural random interpreter to perform a context-sensitive interprocedural analysis with only polynomial increase in running time. This technique involves computing random summaries of procedures, which are complete and probabilistically sound.As an instantiation of this general technique, we obtain the first polynomial-time randomized algorithm that discovers all linear relationships interprocedurally in a linear program. We also obtain the first polynomial-time randomized algorithm for precise interprocedural value numbering over a program with unary uninterpreted functions.We present experimental evidence that quantifies the precision and relative speed of the analysis for discovering linear relationships along two dimensions: intraprocedural vs. interprocedural, and deterministic vs. randomized. We also present results that show the variation of the error probability in the randomized analysis with changes in algorithm parameters. These results suggest that the error probability is much lower than the existing conservative theoretical bounds.