gebhart/patrepeval huggingface dataset:
Dose Performance of a 64-Channel Dual-Source CT Scanner1 (2007)

For electrocardiographically gated coronary CT angiography, image noise equivalent to that of multi-detector row CT can be achieved with dual-source CT at doses comparable to or up to a factor of two lower than the doses at multi-detector row CT, depending on heart rate of the patient.
The NifTK software platform for image-guided interventions: platform overview and NiftyLink messaging (2014)

These packages form part of the NifTK platform and have proven to be successful in a variety of image-guided surgery projects. Code and documentation for the NifTK platform are available from http://www.niftk.org . NiftyLink is provided open-source under a BSD license and available from http://github.com/NifTK/NiftyLink . The code for this paper is tagged IJCARS-2014.
Treatment of Experimental Brain Tumors with Trombospondin-1 Derived Peptides: an In Vivo Imaging Study (1999)

Antiangiogenic and antiproliferative effects of synthetic D-reverse peptides derived from the type 1 repeats of thrombospondin (TSP1) were studied in rodent C6 glioma and 9L gliosarcomas. To directly measure tumor size and vascular parameters, we employed in vivo magnetic resonance (MR) imaging and corroborated results by traditional morphometric tissue analysis. Rats bearing either C6 or 9L tumors were treated with TSP1-derived peptide (D-reverse amKRFKQDGGWSHWSPWSSac, n=13) or a control peptide (D-reverse amKRAKQAGGASHASPASSac, n=12) at 10 mg/kg, administered either intravenously or through subcutaneous miniosmotic pumps starting 10 days after tumor implantation. Eleven days later, the effect of peptide treatment was evaluated. TSP1 peptide-treated 9L tumors (50.7+/-44.2 mm3, n=7) and C6 tumors (41.3+/-34.2 mm3, n=6) were significantly smaller than tumors treated with control peptide (9L: 215.7+/-67.8 mm3, n=6; C6: 184.2+/-105.2 mm3, n=6). In contrast, the in vivo vascular volume fraction, the mean vascular area (determined by microscopy), and the microvascular density of tumors were not significantly different in any of the experimental groups. In cell culture, TSP1, and the amKRFKQDGGWSHWSPWSSac peptide showed antiproliferative effects against C6 with an IC of 45 nM for TSP1. These results indicate that TSP1-derived peptides retard brain tumor growth presumably as a result of slower de novo blood vessel formation and synergistic direct antiproliferative effects on tumor cells. We also show that in vivo MR imaging can be used to assess treatment efficacy of novel antiangiogenic drugs non-invasively, which has obvious implications for clinical trials.
Synthesis of Furanosyl C‐1 Glycals through Palladium‐Catalyzed Reactions of a Furanosyl 2,3‐Anhydro‐exo‐glycal (2009)

Abstract A furanose‐derived 2,3‐anhydro‐ exo ‐glycal, readily available from D ‐mannose in four steps, has proven to be a useful substrate in the preparation of a variety of highly functionalized C‐1 glycals. Upon treatment with Pd 0 it affords a π‐allyl palladium complex that can react with nucleophiles such as amines, ethyl malonate, or vinylstannanes. On the other hand, umpolung of the π‐allyl palladium complex with Et 2 Zn facilitates its reaction with electrophilic aldehydes and ketones.(© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2009)
Plant Triterpenoid Crosstalk: The Interaction of Brassinosteroids and Phytoecdysteroids in Lepidium sativum (2020)

Plant steroid alcohols, plant sterols, are essential components of cell membranes that perform many functions. Their most prominent function is maintaining membrane semipermeability and regulating its fluidity through their specific interaction with phospholipids and membrane proteins. This work is focused on the study of the interaction of two groups of plant sterols, brassinosteroids (BRs) and phytoecdysteroids (PE). Steroid substances belonging to both groups are important signaling molecules essential for plant growth and development, but while the first group has all the known attributes of plant hormones, the second lacks hormonal function in plants. The aim of this preliminary study was to determine at what concentration level and to what extent substances of this type are able to interact with each other, and thus influence the early growth and development of a plant. It was found that exogenously applied PE 20-hydroxyecdysone (20E) significantly reduced the level of endogenous BRs in four-day-old garden cress (<i>Lepidium sativum</i>) seedlings. On the other hand, exogenously applied BRs, 24-<i>epi</i>brassinolide (<i>epi</i>BL), caused the opposite effect. Endogenous 20E was further detected at the picogram level in garden cress seedlings. Thus, this is the first report indicating that this plant species is PE-positive. The level of endogenous 20E in garden cress seedlings can be decreased by exogenous <i>epi</i>BL, but only at a relatively high concentration of 1·10<sup>-6</sup> M in a culture medium. The image analysis of garden cress seedlings revealed that the length of shoot is affected neither by exogenous BRs nor PE, whereas the root length varies depending on the type and concentration of steroid applied.
Problèmes juridiques posés devant la XIIe session de la Conférence générale de l'Unesco (1962)

Lefranc Olivier. Problèmes juridiques posés devant la XIIe session de la Conférence générale de l'Unesco. In: Annuaire français de droit international, volume 8, 1962. pp. 638-675.
Hollow Fibers and Spiral Wound Modules for Ultrafiltration of Whey: Energy Consumption and Performance (1984)

Performances and energy consumption of pilot-scale spiral wound and hollow fiber modules were compared. The feed was cottage cheese whey acidified to pH 3 and prefiltered. Exponential flux decay behavior was typical for both units. Flux was affected by pressure in the first 60 min of operation; for the spiral wound unit, flow rate had a beneficial effect only at pressures above 135 kPa. After 3 to 5 h of operation, however, flux became independent of pressure for both modules; flow rate affected the flux of the hollow fiber module but not of the spiral wound module. The average flux of the hollow fiber unit during concentration of whey was double that of the spiral unit, but energy required for recirculation within the hollow fiber unit was higher. Compared to tubular and plate-and-frame units, the spiral and hollow fiber units consumed 10 to 100 times less energy per unit volume of permeate removed.
Mechanisms underlying losses of heterozygosity in human colorectal cancers (2001)

Losses of heterozygosity are the most common molecular genetic alteration observed in human cancers. However, there have been few systematic studies to understand the mechanism(s) responsible for losses of heterozygosity in such tumors. Here we report a detailed investigation of the five chromosomes lost most frequently in human colorectal cancers. A total of 10,216 determinations were made with 88 microsatellite markers, revealing 245 chromosomal loss events. The mechanisms of loss were remarkably chromosome-specific. Some chromosomes displayed complete loss such as that predicted to result from mitotic nondisjunction. However, more than half of the losses were associated with losses of only part of a chromosome rather than a whole chromosome. Surprisingly, these losses were due largely to structural alterations rather than to mitotic recombination, break-induced replication, or gene conversion, suggesting novel mechanisms for the generation of much of the aneuploidy in this common tumor type.
Subphthalocyanines: Active molecules for molecular photovoltaics (2014)

Reference EPFL-CONF-207228View record in Web of Science Record created on 2015-04-13, modified on 2017-12-03
Melittin Increases Cisplatin Sensitivity and Kills KM-H2 and L-428 Hodgkin Lymphoma Cells (2020)

Hodgkin lymphoma (HL) is neoplasia with high cure rates. However, not all patients can be cured with the current treatment. Chemo-resistance of tumor cells is one factor involved in treatment failure. In addition to its pore-forming activity on lipid bilayer membranes, the toxin melittin from bee venom is an inhibitor of several cancer-related signaling pathways. Moreover, melittin analogs have been shown to inhibit the activity of ATP binding cassette (ABC) transporters which are known to play important roles in the chemo-resistance of tumor cells. Therefore, we tested the toxicity of melittin for HL cell lines KM-H2 and L-428 and whether melittin can increase the chemo-sensitivity of cisplatin-resistant HL cells. We found high toxicity of melittin for KM-H2 and L-428 cells. In co-cultures with normal blood cells, melittin preferentially killed KM-H2 and L-428 cells. In addition, we observed increased cisplatin sensitivity of chemo-resistant L-428 cells after treatment with melittin. ABC transporter activity was not reduced after treatment with melittin. Our data suggest that melittin or melittin analogs might be promising agents for the future development of treatment strategies for HL patients with resistant disease.
PIZZA: A Powerful Image-only Zero-Shot Zero-CAD Approach to 6 DoF Tracking (2022)

Estimating the relative pose of a new object without prior knowledge is a hard problem, while it is an ability very much needed in robotics and Augmented Reality. We present a method for tracking the 6D motion of objects in RGB video sequences when neither the training images nor the 3D geometry of the objects are available. In contrast to previous works, our method can therefore consider unknown objects in open world instantly, without requiring any prior information or a specific training phase. We consider two architectures, one based on two frames, and the other relying on a Transformer Encoder, which can exploit an arbitrary number of past frames. We train our architectures using only synthetic renderings with domain randomization. Our results on challenging datasets are on par with previous works that require much more information (training images of the target objects, 3D models, and/or depth data). Our source code is available at https://github.com/nv-nguyen/pizza.
An Empirical Method to Predict Solubility in Supercritical Fluids (1991)

The ability to predict the solubility of analytes in supercritical fluids is important in understanding supercritical fluid extraction (SFE) and supercritical fluid chromatography (SFC). In SFE, an analyte must dissolve in the supercritical solvent before it can be extracted. Also, in SFC, the knowledge of solubility characteristics of an analyte is necessary to predict its retention characteristics. Thermodynamic methods using a phase equilibrium approach have been used in the past to predict solubility in supercritical fluids. These methods usually involve complicated calculations and need some experimental data to compute unknown parameters. Here we have developed simple empirical methods for predicting solubility as a function of the prevailing temperature, pressure, and density.
Field emission from ultrathin coatings of AlN on Mo emitters (2001)

Experiments characterizing both the physics of emission and the performance of Mo tips coated with ultrathin film of AlN were conducted. Ultrathin films of AlN with thicknesses ranging from 7 to 21 nm in 1.5 nm increments were deposited onto Mo tips by magnetron sputtering. In situ field emission measurements were performed after each deposition step. Tip radius, thickness, and morphology of AlN coating were characterized with the transmission electron microscopy. The effect of the thickness of AlN on emission was determined using a Fowler–Nordheim analysis. Various surface treatment effects were studied and measurements of maximum current and emission stability were performed, e.g., maximum current from a single Mo tip with 15 nm of AlN coating was 52 μA.
Compact, Low Power and Low Threshold Electrically Pumped Micro Disc Lasers for 20Gb/s Non Return to Zero All Optical Wavelength Conversion (2010)

Using a 7.5µm wide InP Micro-Disc-Laser, with a very low ~100µA threshold current, heterogeneously integrated on top of Silicon on Insulator substrate, all optical NRZ wavelength conversion at speeds up to 20Gb/s is demonstrated
Serial hook-ups (2009)

Secure Device Pairing is the bootstrapping of secure communication between two previously unassociated devices over a wireless channel. The human-imperceptible nature of wireless communication, lack of any prior security context, and absence of a common trust infrastructure open the door for Man-in-the-Middle (aka Evil Twin) attacks. A number of methods have been proposed to mitigate these attacks, each requiring user assistance in authenticating information exchanged over the wireless channel via some human-perceptible auxiliary channels, e.g., visual, acoustic or tactile.
In-frame linker insertion mutagenesis of yeast transposon Ty1: phenotypic analysis (1994)

A plasmid bearing a transpositionally functional GAL1::Ty1 fusion was mutagenized by insertion of four or five codons semirandomly throughout the plasmid. This collection of mutant plasmids was introduced into yeast cells and studied with regard to the properties of the mutant Ty1-encoded proteins and the transposition phenotypes observed. All of the transposition-inactivating mutations were previously found to be recessive with the exception of a single mutation in TYA. In this mutant, TYA protein of normal abundance is produced, but the virus-like particles containing this protein are unstable and have aberrant behavior. The effects of mutations in noncoding regions, as well as the capsid protein coding region TYA, and the regions encoding the protease, integrase and reverse transcriptase proteins are described. Effects on gene expression, types of proteins produced, proteolysis of precursor proteins, virus-like particle structure, and biochemical activities of the encoded proteins are summarized. In addition, we show that one of the mutations in the 3' LTR represents a new nonessential site into which foreign marker DNA can be inserted without compromising transposition.
52-Week clinical efficacy with adalimumab in patients with moderately to severely active ulcerative colitis who failed corticosteroids and/or immunosuppressants: Table 1 (2011)

Introduction We report week-52 results from an open-label extension that assessed the efficacy and safety of adalimumab (ADA) in anti-TNF–naïve patients with moderately to severely active ulcerative colitis (UC). Methods Patients were adults with UC (Mayo scores ≥6 points and endoscopic subscores ≥2 points) despite treatment with corticosteroids and/or immunosuppressants. After an 8-week, randomised, placebo-controlled period, patients could enter an open-label extension to receive ADA 40 mg every other week (eow) as maintenance therapy through week 52. Data were analyzed with non-responder imputation (NRI); missing scores and values after adjustment to weekly dosing (for flares/non-response) were imputed as treatment failures. Modified NRI (mNRI) analyses (post-hoc), which did not count patients who dose escalated as failures, and as-observed analyses were also performed. Results Of 390 patients in the primary analysis population, 360 received open-label ADA eow and 117 had their dosages increased to weekly ADA. Mean/median changes in Mayo (0–12) and partial Mayo (0–9) scores from baseline to week 52 (observed values, N=274) were –5.0/–5.0 and –3.7/–4.0, respectively (all p&lt;0.001). The table 1 summarises rates of clinical remission and other secondary end points at week 52. Remission rates at week 52 were 25.6% (NRI) and 29.5% (mNRI). No deaths or cases of tuberculosis were reported. Table 1 PWE-032 Clinical remission and major secondary end points at week 52: all ADAa NRI (N=390) mNRI (N=390) As observed (N=274) Clinical remissionb, n (%) 100 (25.6) 115 (29.5) 115 (42.0) Clinical responsec, n (%) 166 (42.6) 209 (53.6) 209 (76.3) Endoscopy subscore ≤1, n (%) 148 (37.9) 182 (46.7) 182 (66.4) Rectal bleeding score ≤1, n (%) 185 (47.4) 246 (63.1) 246 (89.1)d Stool frequency score ≤1, n (%) 145 (37.2) 175 (44.9) 175 (63.4)d a Pools all randomised groups. b Mayo score ≤2 with no individual subscore &lt;1. c Decrease from baseline in Mayo score ≥3 points and ≥30%, and rectal bleeding subscore 0 or 1 or decrease from baseline ≥1 point. d N=276. Conclusion Treatment with open-label ADA 40-mg eow/weekly generally maintained clinical remission and other efficacy end points in patients with moderately to severely active UC. The safety profile in UC was consistent with the known safety profile of ADA.
A form of BST with small dependence of dielectric constant on voltage (1999)

Abstract Thin films of BaxSryTi1−x−y oxide where x+y <0.5 have been prepared by CVD on Pt coated substrates. Within the above composition space there exist compositions of BST which optimize the tradeoff between large capacitance per unit area and small dependence on applied DC voltage. Such films would be useful as on-chip capacitors where intermodulation distortion or harmonic distortion must be minimized. Capacitance densities > 15 fF/mum2 and a2 coefficients < 100ppm/(volt)2 with low leakage and low loss have been obtained.
Vitreous Prolapse (2013)

There are few absolutes in glaucoma surgery. Here is one: vitreous is bad. Anticipating and avoiding it are the best ways to avoid complications, but managing it is necessary when it rears its ugly head. There are several clinical settings in which vitreous anticipation is appropriate and expected. Recognizing these settings in advance will allow for a prepared surgical approach. Aphakic eyes pose perhaps the highest risk of encountering vitreous during tube shunt placement. In an aphakic eye, the natural barrier holding the vitreous back—the lens and specifically its posterior capsule—is no longer present. These eyes typically have vitreous at or only just behind the pupil, bare millimeters from where the tip of the tube will rest. If vitreous is in the anterior chamber prior to surgery, judicious use of viscoelastics will typically keep the vitreous away from the tube; however, if the vitreous has breached the pupil, it would be wise to clean it up prior to tube insertion. (See below for surgical details.) With vitreous just peeking through the pupil, it might be tempting to try to slip the tube in quickly and get out without stirring things up, with possible success in the short term. Postoperatively, however, if the eye is cursed with a bout of hypotony or as vitreous syneresis progresses, vitreous will almost certainly find its way to the tube lumen, the operation will no longer be successful, and the vitreous will have to be dealt with anyway. Vitreous occasionally presents during cataract surgery, during which time a good clean-up yields a good visual outcome. An incomplete clean-up may also permit a good visual outcome, but leaves the equivalent of a landmine for the glaucoma surgeon who might follow in the cataract surgeon’s wake. It behooves the glaucoma surgeon to review the operative reports for all pseudophakic eyes—particularly those with pseudoexfoliation that are prone to zonular dehiscence and subsequent vitreous laden complications during cataract surgery—so that any encounter with vitreous during tube shunt placement has been anticipated and planned for. The post-traumatic eye can offer a variety of unpleasant surprises for the unprepared surgeon.
FactGraph: Evaluating Factuality in Summarization with Semantic Graph Representations (2022)

Leonardo Ribeiro, Mengwen Liu, Iryna Gurevych, Markus Dreyer, Mohit Bansal. Proceedings of the 2022 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies. 2022.
New renin inhibitors containing novel analogues of statine (1997)

Solid-phase methodology has been used to synthesize a series of peptides based on the N-terminal sequence of human angiotensinogen in which statine (Sta) or the novel analogues (3S,4S)-3,4-diamino- or (3R,4S)-3,4-diamino-6-methylheptanoic acid (Ads or R-Ads) and (3S,4S)-4-amino-3-aminomethyl- or (3R,4S)-4-amino-3-aminomethyl-6-methylheptanoic acid (Amd or R-Amd) replace either residue 10 or both residues 10-11 at the P1-P1' cleavage site. The synthesis of these novel analogues of statine together with biological results on the inhibition of human and rat renin by peptides derived from them is reported. The absolute stereochemistry of the (3S,4S) Ads was determined by an X-ray crystallographic analysis of its N gamma-Boc, B beta-Z, R(+)-1-methyl benzamide derivative. Peptide Boc-His-Pro-Phe-His-Sta-Val-Ile-His-NH2 (VI) is the best inhibitor of human renin containing Sta at position 10. However, peptides containing Ads and Amd gave better rat renin inhibitors than the corresponding Sta-containing peptides. Peptides Boc-His-Pro-Phe-His-Ads-Val-Ile-His-NH2 (VII) having Ads at position 10 had an IC50 of 12 nM against rat renin. Although Sta has come to be accepted as an isosteric replacement for a dipeptide unit rather than for a single amino acid residue, in our series of inhibitors Sta is more effective when replacing only the amino acid at position 10 in the natural angiotensinogen sequence. None of the peptides gave any effect in vivo in a hypertensive rat model.
How Come the Best Job I Ever Had Was When I Worked at a Summer Camp?: Understanding Retention Among Camp Counselors (2013)

When attempting to discover a manner in which to maintain employment during the summer, many individuals have realized the job of camp counselor. What begins as a seasonal position may transform into a lifelong commitment to both person and place. For years, individuals have come to appreciate and understand the experiences that occur when approaching particular places. Data, for this study, was collected via in-depth interviews from twenty-four camp counselors from three separate, but similar camps. Phenomenological analysis on the qualitative data was performed to explore the staff retention amongst counselors. This study links sense of place as a salient component of employee retention among camp counselors. By developing a strong sense of community amongst staff, camp administrators may be promoting a deeper, more long-term, commitment among the staff and towards the camp.