gebhart/patrepeval huggingface dataset:
N‐Cesiocarbazole ṁ pmdta and N‐Potassiocarbazole ṁ pmdta (PMDTA = N,N,N′,N″,N″‐Pentamethyldiethylenetriamine). Cation Size and Multihapto Bonding (1989)

Both σ and π interactions should characterize the solid-state structures of salts such as N lithiopyrrole. This prediction has been only partially confirmed in the case of the lower alkali metals, but carbazole salts of the higher homologues potassium and cesium indeed show multihapto coordinations of eight and nine/eight, respectively. The structure of the Ci-symmetrical dimer of the cesium salt is shown as an example.
Dynamic-susceptibility contrast agent MRI measures of relative cerebral blood volume predict response to bevacizumab in recurrent high-grade glioma (2014)

Standardized rCBV is predictive of OS and PFS in patients with recurrent high-grade brain tumor treated with bevacizumab.
ChemInform Abstract: Chemoenzymatic Synthesis of Enantiomers of a New Retinoid to Investigate the Role of Chirality in the Biological Response. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Photocycloaddition of dimethyl acetylenedicarboxylate to 1,3-dimethylindole (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotocycloaddition of dimethyl acetylenedicarboxylate to 1,3-dimethylindolePaul D. Davis, Douglas C. Neckers, and John R. BlountCite this: J. Org. Chem. 1980, 45, 3, 462–471Publication Date (Print):February 1, 1980Publication History Published online1 May 2002Published inissue 1 February 1980https://pubs.acs.org/doi/10.1021/jo01291a017https://doi.org/10.1021/jo01291a017research-articleACS PublicationsRequest reuse permissionsArticle Views170Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Multifunctional Materials Strategies for Enhanced Safety of Wireless, Skin-Interfaced Bioelectronic Devices (2023)

Many recently developed classes of wireless, skin-interfaced bioelectronic devices rely on conventional thermoset silicone elastomer materials, such as poly(dimethylsiloxane) (PDMS), as soft encapsulating structures around collections of electronic components, radio frequency antennas and, commonly, rechargeable batteries. In optimized layouts and device designs, these materials provide attractive features, most prominently in their gentle, noninvasive interfaces to the skin even at regions of high curvature and large natural deformations. Past work, however, overlooks opportunities for developing variants of these materials for multimodal means to enhance the safety of the devices against failure modes that range from mechanical damage to thermal runaway. This paper presents a self-healing PDMS dynamic covalent matrix embedded with chemistries that provide thermochromism, mechanochromism, strain-adaptive stiffening, and thermal insulation, as a collection of attributes relevant to safety. Demonstrations of this materials system and associated encapsulation strategy involve a wireless, skin-interfaced device that captures mechanoacoustic signatures of health status. The concepts introduced here can apply immediately to many other related bioelectronic devices.
Hydrophilic Interaction Chromatography Hyphenated with Mass Spectrometry: A Powerful Analytical Tool for the Comparison of Originator and Biosimilar Therapeutic Monoclonal Antibodies at the Middle-up Level of Analysis (2017)

The development and approval processes of biosimilar mAbs depend on their comparability to originators. Therefore, analytical comparisons are required to assess structural features and post-translational modifications (PTM) and thereby minimize the risk of being clinically meaningful differences between biosimilar and originator drug products. The glycosylation pattern of mAbs is considered to be an important critical quality attribute (CQA), and several analytical approaches have been proposed that facilitate characterizing and monitoring a glycosylation profile, albeit mainly at a glycan and glycopeptide level of analysis. In this study, we demonstrate the utility of hydrophilic interaction chromatography (HILIC) hyphenated with mass spectrometry (MS) for the qualitative profiling of glycosylation patterns at the protein level, by comparing originator and biosimilars mAbs (Remicade/Remsina/Inflectra, Herceptin/Trastuzumab B, and Erbitux/Cetuximab B) using a middle-up approach. We demonstrate the ability of HILIC to resolve hydrophilic variants of protein biopharmaceuticals at the middle-up level of analysis, its complementarity to reversed phase liquid chromatography, and its hyphenation to MS. HILIC features combined to MS make a powerful analytical tool for the comparison of originator and biosimilar mAbs that could eventually be applied in routine analyses for quality control.
Optimum combining for time hopping impulse radio UWB rake receivers (2004)

In this paper, we present results on the application of reduced-rank adaptive filtering techniques to the problem of interference suppression in ultra-wideband (UWB) communications. It is shown that reduced-rank optimum combining (OC) methods, in particular the eigen-canceler (EC), are effective in suppressing interference modeled as 802.11a signals. Simulation results are presented to show that the EC requires a shorter data record than minimum mean square error (MMSE) RAKE receivers.
Data Supplement from Neuronal Pentraxin 2 Supports Clear Cell Renal Cell Carcinoma by Activating the AMPA-Selective Glutamate Receptor-4 (2023)

&lt;p&gt;Supplementary Figure 2. (A) IF of non-permeabilized KIJ265T cells for NPTX2 expression. (B) Relative NPTX2 expression values of patient gene array data sorted into low versus high NPTX2 expression groups. (C) IF for NPTX2 (far left panel) and Fibronectin (far right panel) in A498 NT vs. sh1316 NPTX2 knockdown cells. 60x magnification of regions highlighted in 20x images are shown (central panels).&lt;/p&gt;
High-$\kappa$/Metal-Gate Fully Depleted SOI CMOS With Single-Silicide Schottky Source/Drain With Sub-30-nm Gate Length (2010)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> Schottky source/drain (S/D) MOSFETs hold the promise for low series resistance and extremely abrupt junctions, providing a path for device scaling in conjunction with a low Schottky barrier height (SBH). A S/D junction SBH approaching zero is also needed to achieve a competitive current drive. In this letter, we demonstrate a CMOS process flow that accomplishes a reduction of the S/D SBH for nFET and pFET simultaneously using implants into a common NiPt silicide, followed by a low-temperature anneal (500 <formula formulatype="inline"><tex Notation="TeX">$^{\circ} \hbox{C}$</tex></formula>–600 <formula formulatype="inline"><tex Notation="TeX">$^{\circ}\hbox{C}$</tex></formula>). These devices have high-<formula formulatype="inline"><tex Notation="TeX">$\kappa$</tex></formula>/metal gate and fully depleted extremely thin SOI with sub-30-nm gate length. </para>
Re: Cells of Renin Lineage Take on a Podocyte Phenotype in Aging Nephropathy (2014)

No AccessJournal of UrologyInvestigative Urology1 Feb 2015Re: Cells of Renin Lineage Take on a Podocyte Phenotype in Aging Nephropathy Anthony AtalaMD Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.11.022AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Cells of Renin Lineage Take on a Podocyte Phenotype in Aging Nephropathy." The Journal of Urology, 193(2), p. 731 © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 2February 2015Page: 731Supplementary Materials Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Anthony Atala More articles by this author Expand All Advertisement PDF downloadLoading ...
Acid ceramidase is a novel drug target for pediatric brain tumors (2017)

Pediatric brain tumors are the most common solid tumors in children and are also a leading culprit of cancer-related fatalities in children. Pediatric brain tumors remain hard to treat. In this study, we demonstrated that medulloblastoma, pediatric glioblastoma, and atypical teratoid rhabdoid tumors express significant levels of acid ceramidase, where levels are highest in the radioresistant tumors, suggesting that acid ceramidase may confer radioresistance. More importantly, we also showed that acid ceramidase inhibitors are highly effective at targeting these pediatric brain tumors with low IC50 values (4.6-50 μM). This data suggests acid ceramidase as a novel drug target for adjuvant pediatric brain tumor therapies. Of these acid ceramidase inhibitors, carmofur has seen clinical use in Japan since 1981 for colorectal cancers and is a promising drug to undergo further animal studies and subsequently a clinical trial as a treatment for pediatric patients with brain tumors.
Segmenting textured 3D surfaces using the space/frequency representation (1994)

Segmenting 3D textured surfaces is critical for general image understanding. Unfortunately, current efforts of automatically understanding image texture are based on assumptions that make this goal impossible. Texture-segmentation research usually assumes that the textures are flat and viewed from the front, while shape-from-texture work assumes that the textures have already been segmented. This deadlock means that none of these algorithms will work reliably on images of 3D textured surfaces. An algorithm has been developed by the authors that can segment an image containing nonfrontally viewed, planar, periodic textures. The spectrogram (local power spectrum) is used to compute local surface normals from small regions of the image. This algorithm does not require unreliable image feature detection. Based on these surface normals, a 'frontalized' version of the local power spectrum is computed that shows what the region's power spectrum would look like if viewed from the front. If neighboring regions have similar frontalized power spectra, they are merged. The merge criterion is based on a description length formula. The segmentation is demonstrated on images with real textures. To the authors' knowledge, this is the first program that can segment 3D textured surfaces by explicitly accounting for 3D shape effects.
Measurement of optical free-form surfaces with fringe projection (2008)

Complex optical free-form surfaces are very common optical components for the use in modern illumination and lighting systems. In this paper we describe the use of high accurate fringe projection for the measurement of optical free-form surfaces with a resolution in the sub-µm-range. To achieve the required high accuracy the method of uniform measurement scale in fringe projection, proposed by the authors some years ago, is used 1. The basic idea is the exclusive use of phase values for the 3D-data calculation. Because of that, the accuracy of such a measurement set-up is mainly restricted by the lens distortion of the projection system. In order to compensate this we introduce a new method for a 3D-correction of the distortion of the projection lens taking into account spatial dependent distortion parameters. The distortion of the projection lens is determined by a measurement of reference planes which will be used to calculate a 3D-correction matrix. This matrix covers the whole measurement volume (lateral and vertical) and contains the determined distortion of the projection system. As a result the accuracy of the correction improved the absolute accuracy by a factor of four. Furthermore, the data quality is enhanced by a further factor of two using a wavelet filtering for noise reduction. The realized measurement set-up has a measurement field of up to 180 mm in diameter. It will be shown that the measurement of optical free form surfaces with medium range accuracy will be possible where we have reached a limit of 0.5 µm RMS error in a measuring field of 70 mm diameter.
Efficient Protection of Probiotics for Delivery to the gastric tract by Cellulose Sulphate Encapsulation (2020)

Abstract Gut microbiota in humans and animals play an important role in health, aiding in digestion, regulation of the immune system and protection against pathogens. Changes or imbalances in the gut microbiota (dysbiosis) have been linked to a variety of local and systemic diseases, and there is growing evidence that restoring the balance of the microbiota can restore health. This can be achieved by oral delivery of members of the microbiome (including probiotics) or by fecal microbiome transplantation. In order to provide their health promoting effects, microbiota must survive (i) transport and storage (i.e. shelf life) and (ii) transit through the highly acid conditions in the stomach and bile salts in the small intestine. We have developed a cell encapsulation technology based on the natural polymer, cellulose sulphate (CS) that protects members of the microbiota from stomach acid and bile.
Time-of-flight mass spectrometry with an electrospray ion beam (1992)

An electrospray ionization source has been coupled to a reflection time-of-flight mass spectrometer. By orienting the ion source perpendicular to the field-free drift region, the longitudinal energy spread of the ion packet has been substantially reduced, allowing a mass resolving power of over 1000 to be achieved for both low-mass and high-mass ions of biological interest. In addition, instrument sensitivity allows the routine detection of low-picomole and subpicomole quantities of large multiply charged species such as cytochrome c (MW = 12,360.9). The potential utility of this instrument for conducting rapid screening of chromatographic effluents is discussed in light of its simplicity, rapid scanning speed, and high sensitivity.
Chemical Durability of SRP Waste Glass - Time Temperature Dependence and Activation Energies for Leaching in Various Leachants (2001)

This study examines the effects of time and temperature on the leaching of Savannah River Plant waste glass. The effects of pH, SA/V ratio, surface finish, protective layers formed, time and temperature are being studied in detail, and the model is being extended by applying it to other waste glass systems.
Retinal fractals and acute lacunar stroke (2010)

This study aimed to determine whether retinal fractal dimension, a quantitative measure of microvascular branching complexity and density, is associated with lacunar stroke. A total of 392 patients presenting with acute ischemic stroke had retinal fractal dimension measured from digital photographs, and lacunar infarct ascertained from brain imaging. After adjusting for age, gender, and vascular risk factors, higher retinal fractal dimension (highest vs lowest quartile and per standard deviation increase) was independently and positively associated with lacunar stroke (odds ratio [OR], 4.27; 95% confidence interval [CI], 1.49-12.17 and OR, 1.85; 95% CI, 1.20-2.84, respectively). Increased retinal microvascular complexity and density is associated with lacunar stroke.
Direct observation of the ultrafast intersystem crossing in tris(2,2′-bipyridine)ruthenium(II) using femtosecond stimulated Raman spectroscopy (2006)

Time-resolved femtosecond stimulated Raman spectroscopy (FSRS) is used to explore the ultrafast intersystem crossing between the metal-to-ligand charge-transfer (MLCT) states of tris(2,2′-bipyridine)ruthenium(II) (). Excitation at 480 nm by a ∼35 fs actinic pump pulse initiates electron transfer from the metal to the bipyridine ligands and the subsequent changes in the vibrational structure of the ligands are probed by FSRS with high spectral (10 cm−1) and temporal (70 fs) resolution. The unique Raman spectral features of the 3MLCT state of appear with rise times from 100 to 130 fs. An upper limit for the initial 1MLCT state lifetime of <30 fs is determined by analysis of the spontaneous emission spectra and quantum yield. The ultrashort lifetime of the 1MLCT state is attributed to fast Franck–Condon vibrational and solvent relaxation of the excited singlet state into near degeneracy with the triplet state, leading to fast and efficient intersystem crossing.
A Real-Time Wireless Sensor Network based on 802.15.4/ZIGBEE to Control Home Automation Environment (2015)

Greenhouse facilitates precise monitoring and con-trolling of various parameters, so as to cultivate quality con-science crops without slaying resources. The cabling laid for the sensors, deployed inside the Greenhouse is not feasible. Hence the need for an automated system employing wireless communication and remote sensing is imperative. This paper proposes a Wireless Sensor Network (WSN) based embedded system and deals with the implementation of ZigBee network (over IEEE 802.15.4) for remote controlling of the Greenhouse parameters. The detailed information regarding establishment of ZigBee network in Star topology as well as in Mesh Topology, inside the Greenhouse is illustrated. It also demonstrates the real time monitoring of parameters such as temperature, humidity, as well as the total power consumption of the system, with the help of a PC based GUI application developed on Java platform.
EFFECTS OF CHRONIC CONVERTING ENZYME INHIBITION ON THE VASCULAR RENIN‐ANGIOTENSIN SYSTEM (1990)

1. The effects of chronic oral administration of inhibitors of angiotensin converting enzyme (ACE) on the vascular renin-angiotensin system were studied. 2. Male Sprague-Dawley rats were treated orally with five ACE inhibitors, captopril, enalapril, ramipril, cilazapril and CS-622 (10 mg/kg per day), for periods of 1-2 weeks. Their mesenteric arteries were then isolated and perfused in vitro with Krebs'-Ringer solution, and the angiotensin II (AII) released into the perfusate was measured under unstimulated and isoproterenol-stimulated conditions. The vascular renin activity was also determined after treatments with ACE inhibitors. 3. Treatment with captopril for 1 week suppressed the isoproterenol-stimulated increase in AII release, but had little effect on the baseline release. Oral treatment with captopril for 2 weeks or with other ACE inhibitors for 1 week markedly inhibited both the unstimulated and stimulated release of AII from the mesenteric vasculature. 4. Both the vascular renin activity and the plasma renin activity increased on captopril treatment, but their changes with time were different. 5. These results indicate that virtually complete inhibition of the vascular renin-angiotensin system can be achieved after prolonged treatment with ACE inhibitors, and suggest that the chronic antihypertensive action of ACE inhibitors is not solely due to inhibition of the plasma renin-angiotensin system.
Expression of trefoil peptides (TFF1, TFF2, and TFF3) in gastric carcinomas, intestinal metaplasia, and non‐neoplastic gastric tissues (2002)

Trefoil factor family (TFF) domain peptides consist of three members that play a role in intestinal mucosal defence and repair, and in tumourigenesis. The role of the three TFF members in the gastric carcinogenesis cascade remains poorly defined. This study examined seven gastric cell lines, 50 gastric cancers and their adjacent non-cancer tissues, and tissues from 40 non-cancer patients, in order to elucidate the chronology of TFF expression in various stages of gastric carcinogenesis. TFF expression was determined by RT-PCR, immunohistochemistry, and western blot. Aberrant expression of TFF1, TFF2, and TFF3 was frequently detected in gastric cell lines. Specifically, TFF1 was detected in all non-cancer patients, but was detected in only 50% of gastric cancer and 66% of adjacent normal tissues. TFF2 expression was demonstrated in 87.5% of non-cancer patients, 34% of gastric carcinomas, and 58% of adjacent non-cancer tissues. There was a significant correlation between TFF1 and TFF2 expression in gastric cancer and adjacent non-cancer tissues (p<0.001). By contrast, TFF3 was detected in 25% of non-cancer patients and showed a predilection for areas with intestinal metaplasia (p=0.005). Sixty-two per cent of gastric cancers and 24% of neighbouring non-cancer tissues showed TFF3 expression. Immunoreactivity against TFF3 was demonstrated in goblet cells of intestinal metaplasia and within the cytoplasm and nuclei of tumour cells. Progressive loss of TFF1 and TFF2, together with the induction of TFF3, is likely to be involved in the early stage of the multi-step gastric carcinogenesis pathway.
Synchrotron radiation-induced surface-conductivity of SiO2 for modification of plasma charging (2000)

In this work, we investigate the electrical surface conductivity that is temporarily induced in SiO2 by exposure to monochromatic vacuum-ultraviolet synchrotron radiation for modification of plasma charging. Special preprocessed test structures were exposed to controlled fluxes of monochromatic synchrotron radiation in the range of 500–3000 Å (approx. 4–25 eV), the energy band of most plasma vacuum-ultraviolet radiation. The highest oxide surface conductivity is achieved during irradiation by photons with energies between 15 and 18 eV. This enhanced oxide surface conductivity holds the potential to discharge high-aspect ratio structures that charge up during plasma processing due to electron shading, and thus minimize plasma-processing-induced damage to semiconductor devices.
Table S6 from The MD Anderson Prostate Cancer Patient-derived Xenograft Series (MDA PCa PDX) Captures the Molecular Landscape of Prostate Cancer and Facilitates Marker-driven Therapy Development (2023)

&lt;p&gt;Ranked expression of genes in MDA PCa 146-10 vs MDA PCa 146-12&lt;/p&gt;