gebhart/patrepeval huggingface dataset:
Cell fate patterning during C. elegans vulval development (1993)

Precursor cells of the vulva of the C. elegans hermaphrodite choose between two vulval cell fates (1 degree and 2 degrees) and a non-vulval epidermal fate (3 degrees) in response to three intercellular signals. An inductive signal produced by the anchor cell induces the vulval precursors to assume the 1 degree and 2 degree vulval fates. This inductive signal is an EGF-like growth factor encoded by the gene lin-3. An inhibitory signal mediated by lin-15, and which may originate from the surrounding epidermis, prevents the vulval precursors from assuming vulval fates in the absence of the inductive signal. A short range lateral signal, which acts through the gene lin-12, regulates the pattern of 1 degree and 2 degree fates assumed by the induced vulval precursors. The combined action of the three signals precisely directs the six vulval precursors to adopt a 3 degree 3 degree 2 degree 1 degree 2 degree 3 degree pattern of fates. The amount of inductive signal produced by the anchor cell appears to determine the number of vulval precursors that assume vulval fates. The three induced vulval precursors most proximal to the anchor cell are proposed to adopt the 2 degree 1 degree 2 degree pattern of fates in response to a gradient of the inductive signal and also in response to lateral signalling that inhibits adjacent vulval precursor cells from both assuming the 1 degree fate.
The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation (2011)

Macrophages are critical players in both innate and adaptive immunity. While the exogenous signaling events leading to the terminal differentiation of macrophages from monocytes have been studied extensively, the underlying intracellular transcriptional mechanisms remain poorly understood. Here we report that the homeobox transcription factor VentX plays a pivotal role in human macrophage terminal differentiation and proinflammatory function. Our study showed that VentX expression was upregulated upon human primary monocyte-to-macrophage differentiation induced by cytokines such as M-CSF, GM-CSF, and IL-3. Moreover, ablation of VentX expression in primary monocytes profoundly impaired their differentiation to macrophages, and ectopic expression of VentX in a myeloid progenitor cell line triggered its differentiation with prominent macrophage features. Further analysis revealed that VentX was pivotal for the proinflammatory response of terminally differentiated macrophages. Mechanistically, VentX was found to control expression of proteins key to macrophage differentiation and activation, including M-CSF receptor. Importantly, preliminary analysis of gene expression in leukocytes from patients with autoimmune diseases revealed a strong correlation between levels of VentX and those of proinflammatory cytokines. Our results provide mechanistic insight into the crucial roles of VentX in macrophage differentiation and proinflammatory activation and suggest that dysregulation of VentX may play a role in the pathogenesis of autoimmune diseases.
Evaluation of glutathione localization in brain using 99mTc meso-HMPAO. (1999)

99mTc meso-HMPAO might be used as an imaging agent to assess GSH localization in the brain.
ChemInform Abstract: Spectroscopy and Dynamics of Resonance Raman Scattering by Iodobenzene Excited in the B Continuum. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Functional Properties of Soy Proteins (1998)

Soy proteins, due to their structural characteristics, deliver a range of functionalities in food products. Extrinsic factors such as temperature, pH, ionic strength, and interaction with other components can also affect protein functionality. Hence, by controlled manipulation of processing conditions, functionalities can be improved to a certain extent. However, further improvement may require changes in protein structure. Chemical, and enzymatic methods can be used to obtain desirable properties by structural modification of soy proteins. Chemical modifications such as phosphorylation, deamidation, acylation and succinylation have been used to improve emulsifying and foaming properties of soy proteins. Hydrolysis of soy protein using enzymes such as trypsin, pepsin, and papain, and protein cross-linking by transglutaminase have been used to improve the functionalities. Adhesive, emulsifying and foaming properties of soy proteins can be utilized in industrial products such as wood adhesive, cosmetic products, and packaging materials.
Flux trapping experiments in single flux quantum shift registers (1997)

As the integration level of superconducting digital circuits increases, flux trapping in these devices becomes a serious problem. High resolution A/D converters and other high speed signal processing systems have been demonstrated with junction counts well into the 10/sup 3/ range. Such large circuits require special testing techniques to prevent flux trapping within the gates, which can reduce bias margins and cause malfunctions of these devices. We discuss the results of experiments using single flux quantum shift registers in which we have varied the ground plane hole pattern and magnetic shield degaussing procedure to minimize flux trapping in these circuits. The operating bias margins of the shift registers have been measured as a function of different testing procedures and ground plane hole designs. In situ degaussing of the magnetic shields aids in the reduction of flux trapping and gave the best results. Measurements of the permeability of mu metal at 4.2 K are discussed.
Conducting Nanocrystal Patterns Using a Silver Organic Complex Blended with Polystyrene as e-Beam Resist (2009)

With the intention of producing a metal composite consisting of Ag nanoparticles embedded in patterned polystyrene, silver triphenylphosphine nitrate, Ag(PPh3)3NO3, was chosen as a source of Ag metal as it is soluble in toluene to form a blend with polystyrene, a well-known negative tone e-beam resist. At a constant e-beam dosage of 150 μC cm−2, the patterns were produced at 5, 10, and 30 keV beam energies while varying the dwell time at a location (pixel) and the number of passes. The presence of Ag in the patterned regions was confirmed by the EDS analysis. TEM showed the formation of small Ag nanoparticles in the embedded matrix of the polymer. The reduction of Ag precursor following exposure to the e beam was monitored by XPS. UV−vis absorption studies showed a broad peak at 464 nm, typical of surface plasmon absorption by Ag nanoparticles. Confocal fluorescence studies showed the embedded Ag nanoparticles in the carbon matrix to have fluorescence property as well. C-AFM measurements have shown that the patterned blend is well conducting due to the interacting Ag nanoparticles, the resistance being two orders less compared to that of polystyrene itself. The higher the beam energy, the lower was the dwell time required to attain a conducting pattern.
Large-Scale Purification of a Stable Form of Recombinant Tobacco Etch Virus Protease (2001)

Tobacco etch virus NIa proteinase (NIa-Pro) has become the enzyme of choice for removing tags and fusion domains from recombinant proteins in vitro. We have designed a mutant NIa-Pro that resists autoproteolytic inactivation and present an efficient method for producing large amounts of this enzyme that is highly pure, active, and stable over time. Histidine-tagged forms of both wild-type and mutant NIa-Pro were overexpressed in E. coli under conditions in which greater than 95% of the protease was in the insoluble fraction after cell lysis. An inclusion body preparation followed by denaturing purification over a single affinity column and protein renaturation yields greater than 12.5 mg enzyme per liter of bacterial cell culture. NIa-Pro purified according to this protocol has been used for quantitative removal of fusion domains from a variety of proteins prepared for crystallization and biochemical analysis.
Subjective evaluation criterion for selecting affective features and modeling highlights (2006)

In this paper, we propose a subjective evaluation criterion which is a guide for selecting affective features and modeling highlights. Firstly, the database of highlights ground truth is established, and both the randomness of the data set and the preparation of the subjects are considered. Secondly, commonly used affective features including visual, audio and editing features are extracted to express the highlights. Thirdly, subjective evaluation criterion is proposed based on the analysis of the average error method and pairwise comparisons method, especially the rationality of this criterion in our specific application is explained clearly according to the three detailed issues. Finally, evaluation experiments are designed on tennis and table tennis as examples. Based on the experiments, we prove that previous works on affective features and linear model highlights are effective. Furthermore, 82.0% (79.3%) affective accuracy is obtained fully automatically by computer which is a marvelous highlights ranking result. This result shows the subjective evaluation criterion is well designed for selecting affective features and modeling highlights.
PIZZA: A Powerful Image-only Zero-Shot Zero-CAD Approach to 6 DoF Tracking (2022)

Estimating the relative pose of a new object without prior knowledge is a hard problem, while it is an ability very much needed in robotics and Augmented Reality. We present a method for tracking the 6D motion of objects in RGB video sequences when neither the training images nor the 3D geometry of the objects are available. In contrast to previous works, our method can therefore consider unknown objects in open world instantly, without requiring any prior information or a specific training phase. We consider two architectures, one based on two frames, and the other relying on a Transformer Encoder, which can exploit an arbitrary number of past frames. We train our architectures using only synthetic renderings with domain randomization. Our results on challenging datasets are on par with previous works that require much more information (training images of the target objects, 3D models, and/or depth data). Our source code is available at https://github.com/nv-nguyen/pizza
Thickness-Dependent Drude Plasma Frequency in Transdimensional Plasmonic TiN (2022)

Plasmonic transdimensional materials (TDMs), which are atomically thin metals of precisely controlled thickness, are expected to exhibit large tailorability and dynamic tunability of their optical response as well as strong light confinement and nonlocal effects. Using spectroscopic ellipsometry, we characterize the complex permittivity of ultrathin films of passivated plasmonic titanium nitride with thicknesses ranging from 1 to 10 nm. By measuring passivated TiN, we experimentally distinguish between the contributions of an oxide layer and thickness to the optical properties. A decrease in the Drude plasma frequency and increase in the damping in thinner films is observed due to spatial confinement. We explain the experimental trends using a nonlocal Drude dielectric response theory based on the Keldysh-Rytova (KR) potential that predicts the thickness-dependent optical properties caused by electron confinement in plasmonic TDMs. Our experimental findings are consistent with the KR model and demonstrate quantum-confinement-induced optical properties in plasmonic transdimensional TiN.
Fully Digital Arrays of Silicon Photomultipliers (dSiPM) – a Scalable Alternative to Vacuum Photomultiplier Tubes (PMT) (2012)

Silicon Photomultipliers (SiPMs) have emerged as promising alternative to fast vacuum photomultiplier tubes (PMT). A fully digital implementation of the Silicon Photomultiplier (dSiPM) has been developed in order to overcome the deficiencies and limitations of the so far only analog SiPMs (aSiPMs). Our sensor is based on arrays of single photon avalanche photodiodes (SPADs) integrated in a standard CMOS process. Photons are detected directly by sensing the voltage at the SPAD anode using a dedicated cell electronics block next to each diode. This block also contains active quenching and recharge circuits as well as a one bit memory for the selective inhibit of detector cells. A balanced trigger network is used to propagate the trigger signal from all cells to the integrated time-to-digital converter. In consequence, photons are detected and counted as digital signals, thus making the sensor less susceptible to temperature variations and electronic noise. The integration with CMOS logic provides the added benefit of low power consumption and possible integration of data post-processing directly in the sensor. In this overview paper, we discuss the sensor architecture together with its characteristics with a focus on scalability and practicability aspects for applications in medical imaging, high energy- and astrophysics.
ReStore - Neural Data Completion for Relational Databases (2021)

Classical approaches for OLAP assume that the data of all tables is complete. However, in case of incomplete tables with missing tuples, classical approaches fail since the result of a SQL aggregate query might significantly differ from the results computed on the full dataset. Today, the only way to deal with missing data is to manually complete the dataset which causes not only high efforts but also requires good statistical skills to determine when a dataset is actually complete. In this paper, we propose an automated approach for relational data completion called ReStore using a new class of (neural) schema-structured completion models that are able to synthesize data which resembles the missing tuples. As we show in our evaluation, this efficiently helps to reduce the relative error of aggregate queries by up to 390% on real-world data compared to using the incomplete data directly for query answering.
Asymmetric K/Li-Ion Battery Based on Intercalation Selectivity (2017)

Using ab initio calculations combined with experimental confirmation, we design an asymmetric intercalation battery using K2NiFeII(CN)6 as the cathode, commercial graphite as the anode, and an organic electrolyte containing mixed lithium and potassium salts. It works by reversible K-ion intercalation at the cathode side and reversible Li-ion intercalation at the anode side simultaneously. The π-electron coordination environment in K2NiFeII(CN)6 ensures the preferred reversible intercalation of the K-ion, and the small ionic radius ensures the preferred reversible intercalation of the Li-ion in graphite. It also shows a high working voltage (∼3.6 V) and an ultralong cycling life with no capacity fading even after 5000 cycles.
Chronic baroreflex activation persistently lowers blood pressure in resistant hypertension: single-center experience with the barostim neo system (2013)

During a 3 months follow up period the development of 24 hour means of outpatients blood pressure (BP) were assessed and correlated with patients baseline apnea-hypopnea-index (AHI) measured by polysomnography and classified by 3 cohorts. Results: After 3 months, the overall reduction in BP was 15 mmHg systolic and 9 mmHg diastolic. 30 patients showed significant reduction in 24h blood pressure evaluation (mean -17/-11mmHg). 10 patients did not respond to RDN (mean RR +7/+4mmHg). While patients without OSA (AHI <5) showed significant BP reduction (-21/-14mmHg), the reduction in those with an AHI ranging between 5 und 20 was weak (-4/-2 mmHg; r= 0,35). In contrast, BP in patients with an AHI above 20 remained unchanged or even increased (mean +4/+2 mmHg). Thus, untreated OSA is a strong predictor of RDN failure (Kruskal Wallis test, p<0,05). No intervention related complications occurred. Conclusion: Renal denervation is an effective therapeutic option for patients with arterial hypertension refractory to an extended drug regimen. Our results show, that the success in BP reduction following RDN depends on patients state free of OSA. Thus, RDN is not a tool for managing resistant AHT in untreated OSA patients.
Evaluation of Boron Solubility in Iron Solid Solution by Radio-frequency Glow-discharge Optical Emission Spectroscopy (2020)

The solubility of boron in α- and γ-iron solid solutions was investigated by diffusion-couple experiments in the Fe-B, Fe-Ni-B, and Fe-Si-B systems. Diffusion couples composed of iron foils and Fe2B bulk specimens were annealed at various temperature between 750ºC and 1100ºC, and the concentration profile of boron from the end-surface of the iron part were measured by the radio-frequency glow-discharge optical emission spectroscopy (rf-GD-OES). It was found that rf-GD-OES was effective in analyzing boron of low concentrations in iron. The solubility limit of boron in α- and γ-iron determined by analyzing the concentration profiles in the diffusion couples was found to agree with that reported by Cameron and Morral for α-iron, and that by Brown et al. for γ-iron. It was also suggested that the invariant reaction between α-iron, γ-iron and Fe2B was a eutectoid reaction, as had been indicated by Cameron and Morral.
Component-based software development-a new paradigm in software engineering? (2002)

Component-based software development is associated with a shift from statement-oriented coding to system building by plugging together components. The idea is not new and some progress has been made over the past decades. Nevertheless, today's software development practice is still far away from the vision. In recent years, the term componentware became the vogue in the software engineering community. The paper defines the relevant terms by relating the definitions to the already well-defined terms of object technology. In particular, the focus lies on a discussion of the deficiencies of the object-oriented paradigm and how componentware might solve these shortcomings.
La cláusula de prevalencia del Derecho estatal y la colisión entre jurisdicciones (2013)

La invalidez de las leyes solamente puede declararla el Tribunal Constitucional, pero cuando un juez aprecia contradiccion entre la legislacion estatal y la legislacion autonomica deberia tener la posibilidad de inaplicar esta ultima en materias de competencia no exclusiva de las Comunidades Autonomas, en consonancia con el papel del juez en el Estado constitucional, la expansion del principio de interpretacion de las leyes conforme a la Constitucion, la influencia del Derecho comunitario y la clausula de prevalencia del Derecho estatal. Se examina el estado de la cuestion en la doctrina cientifica, en la doctrina constitucional y en la jurisprudencia del Tribunal Supremo, postulando una deseable articulacion entre ambas jurisdicciones.
Abstract 18541: Morning Surge of Ventricular Arrhythmias in a New Arrhythmogenic Canine Model of Heart Failure is Associated With Attenuation of Heart Rate and Autonomic Adaptation but Reduced Cardiac Chaos (2013)

Introduction: Ventricular arrhythmias in heart failure (HF) can be modulated by autonomic stimulation that is reflected by heart rate variability (HRV). Noninvasive measures of nonlinear dynamics (NLD) assess cardiac chaos, decrease of which can be detrimental in patients with HF. Holter monitoring of HF patients (to assess HRV &amp; NLD) is limited by concurrent medication use. The aim of this study was to assess arrhythmia development, heart rate (HR) dynamics and nonlinear dynamics in a new arrhythmogenic canine model of HF. Methods: HF was induced in dogs (N=25) by aortic insufficiency &amp; aortic constriction and assessed by echocardiography. Holter monitoring was performed to study time-of-day variation in arrhythmias (PVCs, VT), traditional HRV measures, and nonlinear dynamics (including Shannon entropy (SE), detrended fluctuations analysis α1 and α2 (DFAα1 &amp; DFAα2), and correlation dimension (CD)) at baseline, 240 days (240d) and 720 days (720d) after HF induction. Results: LV fractional shortening decreased from 43.4±0.7 vs 27.5±0.8 % (p&lt;0.01). Both PVCs and VT showed an early morning rise (2.1-fold &amp; 1.9-fold increase at 6AM-noon vs midnight-6AM). An early morning rise in HR at baseline (ΔHR=13.53±1.42 bpm) was attenuated with development of HF (ΔHR=7.06±0.26 and 6.69±2.44 bpm at 240d &amp; 720d; p&lt;0.01, p&lt;0.05), and was shifted to later in the day. Likewise early morning rise in the ratio of low frequency to high frequency (LF/HF, reflecting the ratio of sympathetic to parasympathetic inflow) at baseline was markedly attenuated with HF (p&lt;0.05 at 240d &amp; 720d), suggesting reduced early morning sympathetic adaptation. For nonlinear dynamics, SE, DFAα1, DFAα2, and CD all decreased with HF (3.04±0.02 vs 2.82±0.07, 0.67±0.03 to 0.46±0.03, 0.69±0.02 to 0.56±0.03, all p&lt;0.01; and 1.88±0.13 vs 1.12±0.25, p&lt;0.05 for baseline vs 720d), indicating decreased cardiac chaos in HF dogs. Conclusions: In this new arrhythmogenic canine model of HF, an early morning surge in ventricular arrhythmias was associated with attenuation of morning HR rise and blunting of autonomic oscillation. Measures of nonlinear dynamics reflected a consistent decrease in cardiac chaos and loss of complexity of heart rate that could be contributing to ventricular arrhythmias in this setting.
Supplementary Data from A Novel ACKR2-Dependent Role of Fibroblast-Derived CXCL14 in Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer (2023)

&lt;p&gt;FIGURES. Fig S1, Bioinformatics reveal potential CXCL14-receptor candidates; Fig. S2, Expression of CXCL14 correlates with EMT in breast cancer patients; Fig. S3, Expression of CXCL14 correlates with EMT in breast, prostate and ovarian cancer patients; Fig. S4, Enhanced expression of CXCL14 and ACKR2 correlates with EMT in ovarian and prostate cancer patients; Fig. S5, CXCL14-fibroblasts stimulate the EMT program in xenograft tumors; Fig. S6, Soluble factors secreted by CXCL14-fibroblasts induce EMT of breast cancer cells in vitro; Fig. S7, CXCL14-fibroblasts enhance invasion of breast cancer cells; Fig. S8, CXCL14-responsive and non-responsive breast cancer cell lines; Fig. S9, CXCL14 signals through a Gαi-coupled receptor; Fig. S10, CXCL14 responses depend on ACKR2; Fig. S11, Downregulation of ACKR2 abolishes CXCL14-induced ERK signaling; Fig. S12, CXCL14 is not a direct ligand of ACKR2; Fig. S13, Correlation of CXCL14 expression levels and EMT does not reflect stroma abundance; Fig. S14, Enhanced expression of CXCL14 and ACKR2 predicts worse outcome in breast cancer patients; Fig. S15, Identification of potential mediators of CXCL14-fibroblast- stimulated breast cancer EMT; Fig. S16, A CXCL14-ACKR2-NOS1 axis in fibroblasts stimulates EMT and invasion of breast cancer cells // TABLES. Table S1, Primers for the amplification of human and murine genes by qRT-PCR; Table S2, Scored levels of E-Cadherin and CytK8/18 in MCF7 breast xenograft tumors, and CytK8/18 in LnCaP prostate xenograft tumors; Table S3, CXCL14 candidate receptor expression in CXCL14-responsive and non-responsive cell lines; Table S4, Multivariable analysis for CXCL14high/ACKR2high subgroup of breast cancer patients from the TCGA gene expression dataset; Table S5, Univariable cox-regression analyses for the CXCL14 (high)/ACKR2(high) subgroup (90-percentile) in publicly available gene expression datasets (TCGA) from 13 different tumor types.&lt;/p&gt;