gebhart/patrepeval huggingface dataset:
ChemInform Abstract: 17O NMR Spectroscopy: Applications to Structural Problems in Organic Chemistry (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Growth and spectroscopic properties of 6Li- and 10B-enriched crystals for heat-scintillation cryogenic bolometers used in the rare events searches (2013)

We present the crystal growth of centimeter-sized 6Li6Eu(10BO3)3 and Li6(Eu,Gd)(BO3)3 single crystals by combined Czochralski and Kyropoulos methods, initiated on specifically oriented seeds, with a heretofore unexplored concentration range for heat-scintillation cryogenic bolometers application. The crystal structure and lattice thermal expansion of the former, obtained for the first time by single crystal X-ray diffraction (XRD), and the spectroscopic characterizations together with a consistent set of related thermodynamical properties measurements (magnetic susceptibility, specific heat), also unknown to date, are discussed. Finally, preliminary scintillation measurements at low temperature between 300 and 1100 nm under X-ray excitation are shown.
Photoelectron spectrum, ionization potential, and heat of formation of dichlorocarbene (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoelectron spectrum, ionization potential, and heat of formation of dichlorocarbeneDaniel W. Kohn, Eric S. J. Robles, Cameron F. Logan, and Peter ChenCite this: J. Phys. Chem. 1993, 97, 19, 4936–4940Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/j100121a012https://doi.org/10.1021/j100121a012research-articleACS PublicationsRequest reuse permissionsArticle Views242Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A NIR fluorescent smart probe for imaging tumor hypoxia (2021)

We established the robustness, suitability, and feasibility of NO<sub>2</sub> -Rosol for imaging hypoxia under relevant oxygenation levels in vitro and in vivo via assessing NTR activity in GBM39 models.
Methamphetamine Disrupts Blood–Brain Barrier Function by Induction of Oxidative Stress in Brain Endothelial Cells (2009)

Methamphetamine (METH), a potent stimulant with strong euphoric properties, has a high abuse liability and long-lasting neurotoxic effects. Recent studies in animal models have indicated that METH can induce impairment of the blood-brain barrier (BBB), thus suggesting that some of the neurotoxic effects resulting from METH abuse could be the outcome of barrier disruption. In this study, we provide evidence that METH alters BBB function through direct effects on endothelial cells and explore possible underlying mechanisms leading to endothelial injury. We report that METH increases BBB permeability in vivo, and exposure of primary human brain microvascular endothelial cells (BMVEC) to METH diminishes the tightness of BMVEC monolayers in a dose- and time-dependent manner by decreasing the expression of cell membrane-associated tight junction (TJ) proteins. These changes were accompanied by the enhanced production of reactive oxygen species, increased monocyte migration across METH-treated endothelial monolayers, and activation of myosin light chain kinase (MLCK) in BMVEC. Antioxidant treatment attenuated or completely reversed all tested aspects of METH-induced BBB dysfunction. Our data suggest that BBB injury is caused by METH-mediated oxidative stress, which activates MLCK and negatively affects the TJ complex. These observations provide a basis for antioxidant protection against brain endothelial injury caused by METH exposure.
Constraining theories of semantic memory processing: Evidence from Dementia (1992)

Abstract In this paper we analyse the performance of ten patients with Dementia of the Alzheimer's Type (D.A.T.) who show a pattern of performance suggesting a deficit at the level of semantic memory in the face of normal visual perceptual processing. We use the results of their performance on probe questions for pictures and words to evaluate several hypotheses arising from recent theories concerning semantic memory. We assess whether these patients demonstrate better performance on pictures than words (they do), and whether this can be explained away as a by-product of the perceptual nature of the items tested; pictures whose items have many discernible object parts would tend to contact more residual information in semantic memory, thus producing apparent superior performance from pictures. In fact, we find no support for this explanation. Rather, we are able to demonstrate, in the semantic category of animals, that it is only the items that are correctly identified (as a whole) that will give rise to evidence of better performance on pictures. We then go on to demonstrate that, in contrast to theories suggesting the presence of multiple stores within semantic memory, error analysis of our patients suggests that associative conceptual knowledge is stored amodally … loss of such functional knowledge for pictures is usually accompanied by equal loss of the same information for words. In the discussion section, we present theoretical arguments for a distinction between two kinds of semantic processing; the routines involved in the identification and categorisation of visual instances of concepts, and the associative framework that constitutes our full knowledge of such concepts. We suggest that such a framework is most consistent with the data from our patients. Despite arguments that present theories of semantics are too vague for empirical study, it is possible to test particular elements of such theories and provide data that supports or opposes them.
chTNT-3/hu IL-12 Fusion Protein for the Immunotherapy of Experimental Solid Tumors (2004)

Fusion proteins are emerging as a promising approach for targeting cytokines to the tumor site in order to generate an effective anti-tumor response. In this study, a fusion protein, chTNT-3/huIL-12, consisting of the necrosis targeting antibody, chTNT-3, and human interleukin-12 (IL-12), was constructed and expressed using the glutamine synthetase gene amplification system in NS0 cells. For these studies, IL-12 was chosen since it has been shown to be a powerful anti-tumor cytokine. To generate the fusion protein, an expression vector was prepared by linking the huIL-12 p35 subunit cDNA to the 3' end of the chTNT-3 heavy chain cDNA and the p40 subunit was added to a separate vector. The activity of the expressed chTNT-3/huIL-12 was confirmed by standard IL-12 bioactivity assays which demonstrated that the fusion protein induced similar levels of peripheral blood lymphocyte (PBL) proliferation as free recombinant IL-12. In addition, the lytic activity of the fusion protein was demonstrated in both naive and IL-2-activated lymphocytes using cytotoxicity assays against three human pancreatic and prostatic cancer cell lines (CAPAN, DU145, and PC3-MA). Human PBL incubated with this fusion protein showed an increase in IFN-gamma production which was augmented dramatically by pre-incubation with IL-2. Finally, the immunotherapeutic potential of the fusion protein was demonstrated in the human PBL-SCID mouse model where a 44% reduction in DU145 prostatic tumor growth was obtained compared to control treated mice. These results demonstrate that tumor-targeted human IL-12 may be an effective immunotherapeutic reagent for the treatment of solid tumors in man.
Whole-Genome Sequencing of Invasion-Resistant Cells Identifies Laminin α2 as a Host Factor for Bacterial Invasion (2017)

Pathogenic bacteria penetrate host cellular barriers by attachment to extracellular matrix molecules, such as proteoglycans, laminins, and collagens, leading to invasion of epithelial and endothelial cells. Here, we show that cellular invasion by the human pathogens group B Streptococcus, group A Streptococcus, and Staphylococcus aureus depends on a specific domain of the laminin α2 subunit. This finding may provide new leads for the molecular pathogenesis of these bacteria and the development of novel antimicrobial drugs.
Evolution of morphology and of chemical conversion along the screw in a corotating twin-screw extruder (1999)

A new sampling device is used to perform near-real-time investigations of physical and chemical processes occurring inside a laboratory twin-screw extruder. Polyamide-6–ethylene propylene rubber (PA-6–EPM) blending and styrene–maleic anhydride (SMA) imidation experiments are reported in terms of morphology development and evolution of the chemical conversion along the extruder, respectively. Comparison of the results obtained using this new technique with those of classical screw-pulling experiments evidenced the potential erroneous conclusions than can be drawn from the latter. © 1999 John Wiley & Sons, Inc. J Appl Polym Sci 71: 135–141, 1999
Effect of Highly Exfoliated and Oriented Organoclays on the Barrier Properties of Polyamide 6 Based Nanocomposites (2012)

The influence of the incorporation of nanoparticles (organo-modified montmorillonite Cloisite 30B) in polyamide 6 (PA6) on the transport of small molecules was investigated. Nanocomposites were prepared by melt blending followed by cast extrusion for obtaining film-forming materials. The nanoclay content of the materials was varied from 0 to 5 vol%. Differential scanning calorimetry measurements, electronic microscopy, X-ray diffraction, and rheology were used for characterizing the nanocomposite structure. Because of the presence of nanofillers, a high barrier effect to nitrogen and water was clearly evidenced and mainly attributed to the increase of tortuosity because of the increase of the diffusion pathway generated by impermeable nanofillers. In this study, the high barrier effect was attributed to the very good dispersion of montmorillonite platelets in the PA6 matrix resulting from a two-step melt processing. This peculiar processing has induced a good exfoliation and an orientation parallel to the film surface of lamellar montmorillonite platelets which is clearly demonstrated from transmission electron microscopy analysis. The permeation results were evaluated on the basis of geometrical models proposed by Nielsen and Bharadwaj, and by analyzing the plasticization phenomenon in the case of water permeation involving a concentration-dependence diffusivity correctly approached by an exponential law.
Control of protein activity by photoinduced spin polarized charge reorganization (2022)

Considerable electric fields are present within living cells, and the role of bioelectricity has been well established at the organismal level. Yet much remains to be learned about electric-field effects on protein function. Here, we use phototriggered charge injection from a site-specifically attached ruthenium photosensitizer to directly demonstrate the effect of dynamic charge redistribution within a protein. We find that binding of an antibody to phosphoglycerate kinase (PGK) is increased twofold under illumination. Remarkably, illumination is found to suppress the enzymatic activity of PGK by a factor as large as three. These responses are sensitive to the photosensitizer position on the protein. Surprisingly, left (but not right) circularly polarized light elicits these responses, indicating that the electrons involved in the observed dynamics are spin polarized, due to spin filtration by protein chiral structures. Our results directly establish the contribution of electrical polarization as an allosteric signal within proteins. Future experiments with phototriggered charge injection will allow delineation of charge rearrangement pathways within proteins and will further depict their effects on protein function.
Data from Sodium Channel Subunit SCNN1B Suppresses Gastric Cancer Growth and Metastasis via GRP78 Degradation (2023)

&lt;div&gt;Abstract&lt;p&gt;There remains a paucity of functional biomarkers in gastric cancer. Here, we report the identification of the sodium channel subunit SCNN1B as a candidate biomarker in gastric cancer. &lt;i&gt;SCNN1B&lt;/i&gt; mRNA expression was silenced commonly by promoter hypermethylation in gastric cancer cell lines and primary tumor tissues. Tissue microarray analysis revealed that high expression of SCNN1B was an independent prognostic factor for longer survival in gastric cancer patients, especially those with late-stage disease. Functional studies demonstrated that SCNN1B overexpression was sufficient to suppress multiple features of cancer cell pathophysiology &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;. Mechanistic investigations revealed that SCNN1B interacted with the endoplasmic reticulum chaperone, GRP78, and induced its degradation via polyubiquitination, triggering the unfolded protein response (UPR) via activation of PERK, ATF4, XBP1s, and C/EBP homologous protein and leading in turn to caspase-dependent apoptosis. Accordingly, SCNN1B sensitized gastric cancer cells to the UPR-inducing drug tunicamycin. GRP78 overexpression abolished the inhibitory effect of SCNN1B on cell growth and migration, whereas GRP78 silencing aggravated growth inhibition by SCNN1B. In summary, our results identify SCNN1B as a tumor-suppressive function that triggers UPR in gastric cancer cells, with implications for its potential clinical applications as a survival biomarker in gastric cancer patients. &lt;i&gt;Cancer Res; 77(8); 1968–82. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Klotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K/AKT pathway during tacrolimus-induced oxidative stress (2017)

Mammalian members of the forkhead box protein O (FoxO) class of transcription factors are implicated in the regulation of oxidative stress, and FoxO proteins are negatively regulated by the phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway. We examined the effect of Klotho on the PI3K/AKT pathway and manganese superoxide dismutase (MnSOD) during tacrolimus (Tac)-induced oxidative stress. Klotho-treated mice showed decreased Tac-induced oxidative stress accompanied by functional and histological improvements. Klotho inhibited the PI3K/AKT-mediated phosphorylation of FoxO3a and enhanced FoxO3a binding to the MnSOD promoter. Klotho increased MnSOD mRNA and protein expression in mitochondria. In addition, Klotho reduced Tac-induced mitochondrial dysfunction and decreased mitochondrial reactive oxygen species production, and these effects were enhanced by blocking PI3K activity with LY294002. Collectively, our data showed that Klotho protects Tac-induced oxidative stress by negatively regulating the PI3K/AKT pathway and subsequently enhancing FoxO3a-mediated MnSOD expression.
Azacitidine prolongs overall survival and reduces infections and hospitalisations in patients with WHO-defined acute myeloid leukaemia compared with conventional care regimens: An update (2009)

Azacitidine (AZA), as demonstrated in the phase III trial (AZA-001), is the first MDS treatment to significantly prolong overall survival (OS) in higher risk MDS pts ((2007) Blood 110 817). Approximately, one-third of the patients (pts) enrolled in AZA-001 were FAB RAEB-T (≥20-30% blasts) and now meet the WHO criteria for acute myeloid leukaemia (AML) ((1999) Blood 17 3835). Considering the poor prognosis (median survival <1 year) and the poor response to chemotherapy in these pts, this sub-group analysis evaluated the effects of AZA versus conventional care regimens (CCR) on OS and on response rates in pts with WHO AML.
High-resolution microseismic-source locations and moment-tensor solutions from the Permian Basin (2018)

A detailed microseismic survey was carried out in the Spraberry Field of Midland County, Texas. A vertical pilot well was completed in eight separate stages and was monitored from four surrounding wells within 300 m of the completion well. Each monitor well was equipped with a 20-level 3C geophone array spanning the completion zones. A velocity model was built from dipole sonic and calibrated for vertical transverse isotropy (VTI) parameters using perforation shots, sonic-derived anisotropy, and crosswell seismic time picks. The microseismic locations reveal simple vertical planar clouds only a few meters wide and oriented along maximum horizontal stress direction. Moment tensor solutions show a mix of strike-slip and dipslip shear mechanisms along failure planes aligned with the hydraulic fracture orientation. Formation microimager data indicate that natural fractures play little or no role in generating the microseismicity or guiding fracture growth. The observations indicate that the microseismic shearing is directly associated with the hydraulic fractures. Presentation Date: Wednesday, October 17, 2018 Start Time: 1:50:00 PM Location: 208A (Anaheim Convention Center) Presentation Type: Oral
AN ARCHITECTURE FOR DESIGNERS’ SUPPORT SYSTEMS WITH KNOWLEDGE-EMBEDDED DOCUMENTS (2005)

It is no doubt that engineering design is proceeded with a plenty of knowledge so that knowledge management in design is crucial to support design with computers. There are two aspects for knowledge management in design. One is how knowledge is used in design and the other is how knowledge is represented and maintained. With regard to the former, we
A Push–Pull Parallel Resonant Converter-Based Bidirectional IPT System (2019)

Bidirectional inductive power transfer (BD-IPT) systems facilitate wireless grid integration of electric vehicles to offer vehicle-to-grid (V2G) services. This paper presents a novel push-pull parallel resonant converter-based BD-IPT system to provide a more efficient and cost-effective solution to wireless V2G technologies. The proposed system integrates the functionality of bulky passive elements into a double-D type magnetic coupler to achieve high power density. A phase-delay control technique is proposed to reduce the startup transients as well as to regulate bidirectional power flow between the primary and secondary sides of the push-pull converters. A zero-voltage switching zone is identified to maintain safe operation of the system. Both the operating principles and control philosophy of the converters are described, and a detailed mathematical analysis is presented. The effectiveness of the proposed system is verified by building a 3.3-kW prototype system. The experimental results show that the peak power transfer efficiency reaches 96.5%, and the efficiency remains high under a wide range of operating conditions.
Relationship of the size of the invasive component of the primary breast carcinoma to axillary lymph node metastasis (1995)

In small ductal carcinomas of the breast, the size of only the invasive component, as determined by microscopic measurement, is a better predictor of axillary lymph node status than is the total tumor size. The well established prognostic value of total tumor size largely is due to its reflection of the size of the invasive component.
Clinical stable systemic mastocytosis with interferon alpha 2b therapy. (1997)

Systemic mastocytosis (SM) with progressive infiltration of various organs by mast cells is a rare disease with a mean survival of 2 years. So far there is no established therapy. We describe a patient with progressive mastocytosis who had a clinical response to interferon alpha-2b 3 x 5 Mio U s.c. three times a week. The response is stable 3 years after initiation of therapy and includes reduction of abdominal lymphadenopathy, ascites, decrease of serum and urinary histamine levels as well as pulmonary reticulonodular markings.
ON-ROAD REMOTE SENSING OF AUTOMOBILE EMISSIONS IN THE LOS ANGELES AREA, YEAR 1. (2000)

The University of Denver conducted the second year of a five year remote sensory study in the Los Angeles, California area. The remote sensor used in the study is capable of measuring the ratios of CO, HC, and NO to CO2 in motor vehicle exhaust. From these ratios, the study calculated the percent concentrations of CO, CO2, HC and NO in motor vehicle exhaust which would be observed by a tailpipe probe, corrected for water and any excess oxygen not involved in combustion. The system used in the study was also configured to determine the speed and acceleration of the vehicle and was accomplished by a video system to record the license plate of the vehicle.
Theoretical Modeling of a Hollow Cathode Plasma for the Assessment of Insert and Keeper Lifetimes (2005)

Two theoretical models have been developed to aid the design of hollow cathodes for high power Ion and Hall propulsion that will last longer and perform better.
Identification of Novel Susceptibility Loci for Kawasaki Disease in a Han Chinese Population by a Genome-Wide Association Study (2011)

Kawasaki disease (KD) is an acute systemic vasculitis syndrome that primarily affects infants and young children. Its etiology is unknown; however, epidemiological findings suggest that genetic predisposition underlies disease susceptibility. Taiwan has the third-highest incidence of KD in the world, after Japan and Korea. To investigate novel mechanisms that might predispose individuals to KD, we conducted a genome-wide association study (GWAS) in 250 KD patients and 446 controls in a Han Chinese population residing in Taiwan, and further validated our findings in an independent Han Chinese cohort of 208 cases and 366 controls. The most strongly associated single-nucleotide polymorphisms (SNPs) detected in the joint analysis corresponded to three novel loci. Among these KD-associated SNPs three were close to the COPB2 (coatomer protein complex beta-2 subunit) gene: rs1873668 (p = 9.52×10⁻⁵), rs4243399 (p = 9.93×10⁻⁵), and rs16849083 (p = 9.93×10⁻⁵). We also identified a SNP in the intronic region of the ERAP1 (endoplasmic reticulum amino peptidase 1) gene (rs149481, p(best) = 4.61×10⁻⁵). Six SNPs (rs17113284, rs8005468, rs10129255, rs2007467, rs10150241, and rs12590667) clustered in an area containing immunoglobulin heavy chain variable regions genes, with p(best)-values between 2.08×10⁻⁵ and 8.93×10⁻⁶, were also identified. This is the first KD GWAS performed in a Han Chinese population. The novel KD candidates we identified have been implicated in T cell receptor signaling, regulation of proinflammatory cytokines, as well as antibody-mediated immune responses. These findings may lead to a better understanding of the underlying molecular pathogenesis of KD.
Active Acoustic Control of a Rocket Fairing Using Spatially Weighted Transducer Arrays (2001)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.