gebhart/patrepeval huggingface dataset:
Lessons From Unilateral Loss of Cilia: Early Nasal Nitric Oxide Gas Mixing and the Role of Sinus Patency in Determining Nasal Nitric Oxide (2017)

Nasal nitric oxide (nNO) measurement is a diagnostic test for primary ciliary dyskinesia (PCD). Here, we have shown the development of unilateral PCD-like symptoms associated with low nNO. A 60-year-old man had been previously healthy but developed unilateral, severe pansinusitis. He required surgical drainage of all left sinuses, and biopsies showed loss of the ciliated epithelium. At 4 weeks, he had unilateral (left-sided), profuse, clear rhinorrhea characteristic of PCD, and his surgical ostia were all patent endoscopically. His left-sided nNO was less than the right side by 37 ± 1.2 nL/min; this difference decreased to 18 ± 0.87 nL/min at 5 weeks and was gone by 6 weeks when his symptoms resolved. Measurements of 2- and 10-second measurements, in addition to standard nNO measurements, identified this discordance. We conclude that nNO reflects, in part, the production of NO by the ciliated epithelium, not just in the absence or occlusion of sinuses. Early (nasal/sinus volume) measures may be better for diagnosing PCD in than standard, steady-state assays in certain populations.
Hormonology: a genomic perspective on hormonal research (2005)

Recent advances in comparative genomics allow a new paradigm for hormonal research. At the centennial of the first use of the term hormone by Ernest Starling, we reflected on the changing approaches in elucidating hormonal signaling mechanisms and highlighted the inadequacy of the term endocrinology, implying remote activation, to describe the diverse modes of hormone actions. Several examples were presented to underscore the power of comparative genomics in the identification of new polypeptide hormones, receptors, and signaling pathways. We propose the use of the term hormonology to more accurately reflect the expanding boundaries of the discipline.
Development of an Electrophotographic Laser Intensity Modulation Model for Extrinsic Signature Embedding (2007)

In our previous work, we have demonstrated techniques to embed and extract extrinsic signatures from halftone images and text documents. Well developed embedding algorithms should increase the payload capacity while enhance the reliability of detection. In this study, we will develop a printer model that will be used to optimize the embedding algorithm for capacity and detection reliability. The model incorporates the impact of the process modulation parameter, e.g. laser intensity, with a stochastic dot interaction model to estimate the impact of the modulation on a known halftone pattern. Experimental data validated the effectiveness of the proposed model in predicting the impact of laser intensity modulation on the reflectance of the printout.
Probabilistic testing for stochastic hybrid systems (2008)

In this paper we propose a testing based method for safety/ reachability analysis of stochastic hybrid systems. Testing based methods are characterized by analysis based on the execution traces of the system or the simulation thereof. Testing based method is very appealing because of the simplicity of its execution, the possibility of having a partial verification, and its highly parallel structure. The key idea in this paper is the construction of a robust neighborhood consisting of states that have the same probabilistic safety/reachability properties. We construct the robust neighborhood using the level sets of a stochastic bisimulation function. We also show how to construct stochastic bisimulation functions for systems whose continuous dynamics is stable and linear. As a case example, we consider the problem of conflict detection of aircraft flight, and show that we can infer some robust probabilistic safety property by using the algorithm that we present in this paper.
Personal Media Alert Systems: Personalization and Dissemination of Broadcast Content with a P2P Micropayment Scheme (2006)

Media consumers who are overwhelmed by multitudinous news content demand a system that would sift through tens or hundreds of broadcast TV channels on a daily basis to capture the most important clips that match users' interests and deliver these personalized clips for easy viewing on a typical TV or home PC. In this paper, we present a personal media alert system that extracts video segments for the interested users. In addition, alerts with pointers to content stored on the home server can be sent to mobile users who are authorized to access the content at home. To make content sharing feasible and scalable, we also propose a P2P payment scheme that would allow a consumer to have access to media clips aggregated on other consumers' personal media systems
Anisotropy quantum beat in two-photon ionization of coherently excited hyperfine states of Na (2001)

A new method is proposed that utilizes the quantum beat of polarization anisotropy in two-photon ionization of atoms and molecules. It was shown that the frequency and the amplitude of the beating anisotropy contain information on, respectively, the hyperfine constants of the electronically excited state and the branching ratio of the photoionization channels leading to different photoelectron angular momentum states in the ionization continuum. The method was demonstrated for the case of the Na 3p P3/22 state by the time-resolved two-photon ionization with two pulses of parallel and perpendicular polarizations.
Kinetic analysis of intracellular Hoechst 33342—DNA interactions by flow cytometry: Misinterpretation of side population status? (2012)

We outline a simple approach involving instrument setup and calibration for the analysis of Hoechst dye 33342-loading in human cell lines for exploring heterogeneity in dye efflux efficiency and the status of side population (SP) A549 lung cancer cells. Dual excitation 488 nm/multiline UV (351-364 nm) flow cytometry was used to confirm ABCG2-specific inhibition of dye efflux using Fumitremorgin C. Transporter gene expression, assayed by qRT-PCR, confirmed higher expression of ABCG2 versus ABCB1, reiterated in a cloned subline. Coexpression of aldehyde dehydrogenase genes ranked as aldehyde dehydrogenase class 1A1 (ALDH1A1) > ALDH3A1 > ALDH3, relative expression of all genes was again reiterated in a cloned subline. Permeabilized cells were used to create red:violet (660:405 nm Em wavelengths) ratiometric references for mapping temporal changes in Hoechst 33342-DNA fluorescence in live cells. A live cell "kinetic SP gate" tracked progressive dye loading of the whole population and coapplication of the far red (>695 nm wavelength) fluorescing dye DRAQ7 enabled viable cell gating. Kinetic gating revealed a continuum for dye accumulation suggesting that SP enumeration is critically dependent upon the nonlinear relationship of the spectral shift with progressive dye-DNA binding and thus requires accurate definition. To this end, permeabilized cell reference samples permit reproducible instrument setup, guide gate boundaries for SP and compromised cells, and offer a simple means of comparing SP enumeration across laboratory sites/platforms. Our approach reports the dynamic range for the spectral shift, revealing noninformative staining conditions and explaining a source of variability for SP enumeration. We suggest that live cell kinetic sorting of all cells with the same dye:DNA load but with differences in efflux capacity can be used to explore drug resistance capability without prejudice. The SP phenotype should be regarded as a kinetic parameter and not a fixed characteristic--critical for functional assay design and the interpretation of heterogeneity.
Hidden Markov model with information criteria clustering and extreme learning machine regression for wind forecasting (2015)

This paper proposes a procedural pipeline for wind forecasting based on clustering and regression. First, the data are clustered into groups sharing similar dynamic properties. Then, data in the same cluster are used to train the neural network that predicts wind speed. For clustering, a hidden Markov model (HMM) and the modified Bayesian information criteria (BIC) are incorporated in a new method of clustering time series data. To forecast wind, a new method for wind time series data forecasting is developed based on the extreme learning machine (ELM). The clustering results improve the accuracy of the proposed method of wind forecasting. Experiments on a real dataset collected from various locations confirm the method's accuracy and capacity in the handling of a large amount of data.
Highly proliferative primitive fetal liver hematopoietic stem cells are fueled by oxidative metabolic pathways (2015)

Hematopoietic stem cells (HSCs) in the fetal liver (FL) unlike adult bone marrow (BM) proliferate extensively, posing different metabolic demands. However, metabolic pathways responsible for the production of energy and cellular building blocks in FL HSCs have not been described. Here, we report that FL HSCs use oxygen dependent energy generating pathways significantly more than their BM counterparts. RNA-Seq analysis of E14.5 FL versus BM derived HSCs identified increased expression levels of genes involved in oxidative phosphorylation (OxPhos) and the citric acid cycle (TCA). We demonstrated that FL HSCs contain more mitochondria than BM HSCs, which resulted in increased levels of oxygen consumption and reactive oxygen species (ROS) production. Higher levels of DNA repair and antioxidant pathway gene expression may prevent ROS-mediated (geno)toxicity in FL HSCs. Thus, we here for the first time highlight the underestimated importance of oxygen dependent pathways for generating energy and building blocks in FL HSCs.
A small molecule inhibitor of Rheb selectively targets mTORC1 signaling (2018)

The small G-protein Rheb activates the mechanistic target of rapamycin complex 1 (mTORC1) in response to growth factor signals. mTORC1 is a master regulator of cellular growth and metabolism; aberrant mTORC1 signaling is associated with fibrotic, metabolic, and neurodegenerative diseases, cancers, and rare disorders. Point mutations in the Rheb switch II domain impair its ability to activate mTORC1. Here, we report the discovery of a small molecule (NR1) that binds Rheb in the switch II domain and selectively blocks mTORC1 signaling. NR1 potently inhibits mTORC1 driven phosphorylation of ribosomal protein S6 kinase beta-1 (S6K1) but does not inhibit phosphorylation of AKT or ERK. In contrast to rapamycin, NR1 does not cause inhibition of mTORC2 upon prolonged treatment. Furthermore, NR1 potently and selectively inhibits mTORC1 in mouse kidney and muscle in vivo. The data presented herein suggest that pharmacological inhibition of Rheb is an effective approach for selective inhibition of mTORC1 with therapeutic potential.
New techniques in geochemical analysis (1966)

Thin layer and gas chromatography, Mossbauer and atomic absorption spectrometry, fission track analysis, X-ray fluorescence spectroscopy, and other methods employed in geochemistry
Capillary gas chromatography/mass spectrometric determination of nitrogen aromatic compounds in complex mixtures (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCapillary gas chromatography/mass spectrometric determination of nitrogen aromatic compounds in complex mixturesMilos. Novotny, Robin. Kump, Franco. Merli, and L. J. ToddCite this: Anal. Chem. 1980, 52, 3, 401–406Publication Date (Print):March 1, 1980Publication History Published online1 May 2002Published inissue 1 March 1980https://pubs.acs.org/doi/10.1021/ac50053a008https://doi.org/10.1021/ac50053a008research-articleACS PublicationsRequest reuse permissionsArticle Views148Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy (2022)

Studies are needed to evaluate the safety and effectiveness of mRNA SARS-CoV-2 vaccination during pregnancy, and the levels of protection provided to their newborns through placental transfer of antibodies. Here, we evaluate the transplacental transfer of mRNA vaccine products and functional anti-SARS-CoV-2 antibodies during pregnancy and early infancy in a cohort of 20 individuals vaccinated during late pregnancy. We find no evidence of mRNA vaccine products in maternal blood, placenta tissue, or cord blood at delivery. However, we find time-dependent efficient transfer of IgG and neutralizing antibodies to the neonate that persists during early infancy. Additionally, using phage immunoprecipitation sequencing, we find a vaccine-specific signature of SARS-CoV-2 Spike protein epitope binding that is transplacentally transferred during pregnancy. Timing of vaccination during pregnancy is critical to ensure transplacental transfer of protective antibodies during early infancy.
Influence of high deformation on the microstructure of low-carbon steel (2014)

在汽车的工业使用的低碳的钢表 DC04 受到从 20% ～ 89% 的为厚度减小的冷滚动。需要的厚度被连续减小用一家滚动工厂完成。微观结构上的厚度减小的影响被扫描电子显微镜学学习。微观结构进化被谷物和面向的谷物结构的出现的失真为高冷的工作描绘。谷物为高冷的工作重构的机制被描述。虚空的出现与冷工作在关系被讨论。在谷物边界并且在谷物内的虚空的进化也被考虑。描绘谷物尺寸， Feret 直径被测量，谷物尺寸分发对冷工作被讨论。样品的化学同质也被分析。
A Droplet-Based Microfluidics Route to Temperature-Responsive Colloidal Molecules (2019)

Small clusters of spherical colloids that mimic real molecules, so-called colloidal molecules, hold great promise as building blocks in bottom-up routes to new materials. However, their typical hard sphere nature has hampered their assembly into ordered structures, largely due to a lack of control in the interparticle interactions. To provide easy external control of the interactions, the present work focuses on the preparation of colloidal molecules from temperature-responsive microgel particles that undergo a transition from a soft repulsive to a short-range attractive state as their characteristic volume phase transition temperature (VPTT) is crossed. Preparation of the colloidal molecules starts with the use of a droplet-based microfluidics device to form highly uniform water-in-oil (W/O) emulsion droplets containing, on average and with a narrow distribution, four microgels per droplet. Evaporation of the water then leads to the formation of colloidal molecule-like clusters, which can be harvested following cross-linking and phase transfer. We use a mixture of two types of microgels, one based on poly(<i>N</i>-isopropylacrylamide) (PNIPAM) and the other on poly(<i>N</i>-isopropylmethacrylamide) (PNIPMAM), to prepare bicomponent colloidal molecules, and show that the difference in VPTT between the two allows for induction of attractive interparticle interactions between the PNIPAM interaction sites at temperatures in between the two VPTTs, analogous to the interactions among patchy biomacromolecules such as many proteins.
Tantalum–ruthenium dioxide as a diffusion barrier between Pt bottom electrode and TiSi2 ohmic contact layer for high density capacitors (1999)

The effects of RuO2 addition on the barrier properties of the Ta layer were investigated at the temperature range of 650–800 °C in air. For the Pt/Ta/TiSi2/poly-Si/SiO2/Si structure, its layer structure was completely collapsed after annealing at 650 °C, resulting in higher total resistance and Schottky characteristics. For the Pt/Ta+RuO2/TiSi2/poly-Si/SiO2/Si structure, however, it exhibited the lower total resistance and ohmic characteristics, and its layer structure was retained up to 800 °C. A Ta amorphous structure by the chemically strong Ta–O or Ta–Ru–O bonds and nonstoichiometric, nanocrystalline RuOx resulted in the formation of a conductive RuO2 phase in the Ta+RuO2 barrier film after an annealing, leading to the prevention of the interdiffusion of Pt, Si, and external oxygen through the diffusion barrier as well as surface oxidation up to 800 °C. Therefore, the thermal stability for the Pt/Ta+RuO2/TiSi2/poly-Si/SiO2/Si structure was higher than that for Pt/Ta/TiSi2/poly-Si/SiO2/Si structure.
A Flow Information-Based Prediction Model Applied to the Nonaxisymmetric Hub Optimization of a Centrifugal Impeller (2021)

Abstract A full-range prediction model for turbomachinery based on the flow-field information code is established in this article to solve the problems that traditional models do not have enough prediction accuracy and cannot reflect the complete performance characteristics of the impeller. The model, which can predict the complete performance curve of the impeller with higher accuracy, consists of two multilayer artificial neural network (ANN) submodels. Different from the traditional model, the ANN submodel uses the flow-field information code for pretraining layer by layer. The flow-field information code is the characteristic information extracted from the impeller flow field through the proper orthogonal decomposition (POD) method. By implicitly learning the flow-field information, the prediction error of the model is reduced by 29.7% compared with the single hidden layer ANN. Based on this model, the nonaxisymmetric, but periodic, hub optimization of a centrifugal impeller with 30 variables is carried out, with the goals of the higher efficiency and the wider flow range at the specified pressure ratio and the massflow rate at the design point. The result shows that, after the optimization, the isentropic efficiency at the design point increases by 1% and the flow range increases by 2% compared to the baseline.
Innovative Modelling Method of Diagenetic Overprints in Carbonate Reservoirs (2012)

Abstract Modelling products of diagenetic processes in carbonate reservoirs is still a challenge since both stochastic and physicochemical simulations cannot easily reproduce complexity of features generated by those processes. An alternative way to modelling diagenetic overprints deals with an innovative methodology based on process-like simulation of the fluid-rock interaction and its effects on reservoir properties. The principle of the method is related to a lattice gas automata used to mimic the diagenetic fluid flows and to reproduce the diagenesis effects through the evolution of both mineralogical composition and petrophysical properties. This new modelling approach is well adapted to handle dolomitization processes and was applied on two case studies. In the Urgonian carbonates, (Barremian-early Aptian) characterized by a platform facies predominantly of rudists and bioclastic/ooid grainstone (S.E. France), five main diagenetic stages have been identified. The 2D modelling focuses on dedolomitization features located on parasequence boundaries. In the Venetian platform (Lias, N.E. Italy), data collected show four diagenetic stages. The main one, related to dolomitization along fractures, is called per-ascensum dolomitization. Three of the diagenetic stages have been simulated on a 3D depositional model previously filled with initial facies and original petrophysical properties. The simulations of the Urgonian series lead to generate dedolomitized bodies related to surface boundaries that match those identified on the outcrop. Calibration on actual data of diagenetic parameters used for per-ascensum dolomitization modelling of the Venetian platform also enables to reproduce and to visualize the displacement of dolomitizing fluids in the fracture network and within the stratigraphical layers. In both cases, the evolution of the mimetic diagenetic fluid effects on mineralogical composition property can be followed through space and numerical time, which helps to understand the heterogeneity of reservoir properties. This method enables the modelling of diagenetic overprints without any explicit physicochemical equation in any carbonate reservoir for which diagenetic products are generated through fluid transport.
An ultrafast time‐resolved infrared and UV–vis spectroscopic and computational study of the photochemistry of acyl azides (2012)

The photochemistry of pivaloyl, benzoyl, 4‐phenylbenzoyl, and 2‐anthroyl azides has been studied using femtosecond (fs) time‐resolved infrared (TRIR) and UV–vis spectroscopy and interpreted with the aid of computational chemistry. Density functional theory calculations revealed a significant difference in the nature of the lowest singlet excited state for these carbonyl azides. The lowest singlet excited states ( S 1 ) of p ‐phenylbenzoyl and 2‐anthroyl azides are (π,π*) in nature, while the pivaloyl and benzoyl azides S 1 states involve ( n ,π*) excitations. Nevertheless, for all acyl azides studied here, a similar, and intense, IR band at about 2100 cm −1 has been detected in the ultrafast TRIR experiments following 270 nm excitation. These bands were shifted to lower energy by about 100 cm −1 relative to the N 3 stretching mode for the ground states of these azides. These 2100 cm −1 vibrational bands were assigned to the S 1 states of acyl azides in agreement with density functional theory calculations. The decay of the acyl azide S 1 states was described by bi‐exponential functions. The fast component was attributed to the decay of the hot S 1 state and the longer component to the decay of the thermally relaxed S 1 state. A strong and broad transient absorption in the 350–650 nm spectral range was observed in the fs UV–vis experiments for p ‐phenylbenzoyl and 2‐anthroyl azides. The carrier of this absorption also decayed bi‐exponentially, and the time constants were in excellent agreement with those found in the fs TRIR experiments. The slow component of the S 1 state decay was found to be dependent on the solvent polarity. When the lifetime of the acyl azide S 1 state is substantially longer than the time constant for vibrational cooling of nascent (hot) isocyanate, the correlation between the S 1 decay and isocyanate formation was clear. The 270 nm excitation populates the S n ( n ≥ 2) states of these acyl azides. It was established that a hot nitrene is produced more efficiently from both the S n and hot S 1 states than from the relaxed S 1 state of these acyl azides. Thus, time‐resolved study provides direct experimental evidence that the S 1 state is the precursor of nitrene only when the S 1 state is pumped directly and when the S 1 state lifetime is longer than the time constant of vibrational cooling of the newborn nitrene. All of these results are consistent with the data obtained recently for 2‐napththoyl azide. Copyright © 2012 John Wiley &amp; Sons, Ltd.
ChemInform Abstract: SYNTHESIS, β‐ADRENERGIC ACTIVITY, AND PLATELET ANTIAGGREGATORY ACTIVITY OF A POSITIONAL ISOMER OF TRIMETOQUINOL: 1‐(2′,4′,5′‐TRIMETHOXYBENZYL)‐6,7‐DIHYDROXY‐1,2,3,4‐TETRAHYDROISOQUINOLINE (1980)

Abstract Gemäß Formelbild wird das Isomere (VI) von Trimetoquinol (I) dargestellt.