gebhart/patrepeval huggingface dataset:
Towards a dynamic SDN virtualization layer: Control path migration protocol (2015)

Virtualization of software defined networks enables tenants to bring their own controller and manage their virtual resources with the full programmability provided by Software Defined Networking (SDN). Distributed SDN hypervisors are proposed to provide an efficient platform for the virtualization of physical SDN networks. They address the issue of scalability that a centralized hypervisor could suffer from. As virtualization provides the possibility to change virtual SDN networks on run time, a hypervisor layer needs efficient mechanisms to dynamically adapt to the changing requirements. Existing proposals provide only a static configuration setup for their distribution of the hypervisor instances. However, in order to satisfy the dynamics of virtual SDN networks, management protocols are needed to support dynamic changes. In this paper, we propose a control path migration protocol for distributed hypervisors. Such protocol is needed to support the dynamic adaptation of the virtualization layer. Our protocol is providing the missing procedure that allows a dynamic change of control connections between virtual SDN networks and the tenants' controllers, respectively. We provide a proof of concept implementation for our proposal. Through measurements in a real testbed setup, we show that our protocol is efficient in terms of control latency overhead and provides transparency to the controllers of the virtual SDN networks.
Optimization of Processing and Modeling Issues for Thin Film Solar Cell Devices Including Concepts for The Development of Polycrystalline Multijunctions: Annual Report; 24 August 1998-23 August 1999 (2000)

This report describes results achieved during phase 1 of a three-phase subcontract to develop and understand thin-film solar cell technology associated to CuInSe{sub 2} and related alloys, a-Si and its alloys, and CdTe. Modules based on all these thin films are promising candidates to meet DOE long-range efficiency, reliability, and manufacturing cost goals. The critical issues being addressed under this program are intended to provide the science and engineering basis for the development of viable commercial processes and to improve module performance. The generic research issues addressed are: (1) quantitative analysis of processing steps to provide information for efficient commercial-scale equipment design and operation; (2) device characterization relating the device performance to materials properties and process conditions; (3) development of alloy materials with different bandgaps to allow improved device structures for stability and compatibility with module design; (4) development of improved window/heterojunction layers and contacts to improve device performance and reliability; and (5) evaluation of cell stability with respect to illumination, temperature, and ambient and with respect to device structure and module encapsulation.
Independent constitutive expression of the aerobic and anaerobic pathways of glycerol catabolism in Klebsiella aerogenes (1975)

Klebsiella aerogenes dissimilates glycerol aerobically via an inducible pathway initiated by an adenosine triphosphate-linked kinase that converts the substrate to sn-glycerol 3-phosphate. Phosphorylated glycerol is then dehydrogenated to dihydroxyacetone phosphate by an enzyme characteristic of a flavoprotein. Anaerobically, the organism dissimilates glycerol via an inducible pathway initiated by a nicotinamide adenine dinucleotide-linked dehydrogenase that converts the substrate to dihydroxyacetone. The keto product is then phosphorylated by another adenosine triphosphate-linked kinase. Two kinds of constitutive mutants have been isolated: one affecting the aerobic and the other the anaerobic pathway.
Application des fonctions-spline au traitement d'images numériques (1987)

Étude portant sur la modélisation d'images a traiter. Application des fonctions spline. Diverses techniques d'approximation sont mises en œuvre et des algorithmes spécifiques sont développés pour s'adapter au volume important des données. L'intérêt de cette représentation confirmée est illustré sur trois exemples d'origine médicale
Application oriented tribological test concepts (2017)

The tribotesting categories have different scopes with associated pros and cons and results obtained in one category cannot be simply transferred to another. The impact of design overrules in general the influence of the metallurgy or materials choice. The cheap test methods aim pre-screening and assessment of basic properties as well as use mainly for the test specimens SAE E52100 (100Cr6, SUJ2) ball bearing steel and carbon steels. The main test geometries are ball-on-flat/(disk) or block-on-ring apart 4-ball geometry. The tribological test conditions. This enabled dynamic testing, where during a test the critical solicitations were repeatedly and freely passed.
The TROVE module: A common element in Telomerase, Ro and Vault ribonucleoproteins (2003)

This work suggests that a number of ribonucleoprotein components use a common RNA-binding module. The TROVE module is also found in bacterial ribonucleoproteins suggesting an ancient origin for these ribonucleoproteins.
On Generalizing Beyond Domains in Cross-Domain Continual Learning (2022)

Humans have the ability to accumulate knowledge of new tasks in varying conditions, but deep neural networks often suffer from catastrophic forgetting of previously learned knowledge after learning a new task. Many recent methods focus on preventing catastrophic forgetting under the assumption of train and test data following similar distributions. In this work, we consider a more realistic scenario of continual learning under domain shifts where the model must generalize its inference to an unseen domain. To this end, we encourage learning semantically meaningful features by equipping the classifier with class similarity metrics as learning parameters which are obtained through Mahalanobis similarity computations. Learning of the backbone representation along with these extra parameters is done seamlessly in an end-to-end manner. In addition, we propose an approach based on the exponential moving average of the parameters for better knowledge distillation. We demonstrate that, to a great extent, existing continual learning algorithms fail to handle the forgetting issue under multiple distributions, while our proposed approach learns new tasks under domain shift with accuracy boosts up to 10% on challenging datasets such as DomainNet and OfficeHome.
Identification of antigenic sites on pseudorabies virus glycoprotein gp50 implicated in virus penetration of the host cell (1990)

Five monoclonal antibodies specific for glycoprotein gp50 of pseudorabies virus were used to make a topographical map of gp50 and to determine the biological function of the different antigenic domains. Three antigenic domains were identified by competition binding assays and additivity assays (IA, IB, II). Domain IA corresponds to a continuous epitope, whereas domains IB and II consist of one or several discontinuous epitopes, identified by their resistance to heat or reducing treatments. Domains IA and IB correspond to sites highly involved in virus neutralization. Neutralization experiments by monoclonal antibodies recognizing domains IA and IB and performed before or after adsorption of virions to cells showed that these domains have a role in penetration of virus into the cell.
Iron(II) Complex of Octopus-Porphyrin with a Covalently Linked Proximal Imidazole; Self-Assembly and O2-Coordination in Aqueous Media (2001)

Abstract The iron complex of tetrakis[2,6-di(alkanoyloxy)phenyl]porphyrin derivative with seven phosphocholine head groups and an N-alkylimidazole side-chain as the proximal base (octopus-porphyrin) has been synthesized. The ferrous complex (7b) was easily dispersed in water to provide a stable colloid. Transmission electron microscopy and scanning force microscopy of the evaporated solution showed spherical micelles with a diameter of 8 nm, which probably consists of a dimer of 7b. These micellar aggregates could reversibly coordinate O2 at 25 °C; and the O2-binding parameters are also given.
ChemInform Abstract: Synthesis of 2,3‐Disubstituted 4‐Oxoquinolines and 3‐Substituted Fused 4‐Oxoquinolines. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Ibuprofen loaded PLA nanofibrous scaffolds increase proliferation of human skin cells in vitro and promote healing of full thickness incision wounds in vivo (2015)

This article presents successful incorporation of ibuprofen in polylactic acid (PLA) nanofibers to create scaffolds for the treatment of both acute and chronic wounds. Nanofibrous PLA scaffolds containing 10, 20, or 30 wt % ibuprofen were created and ibuprofen release profiles quantified. In vitro cytotoxicity to human epidermal keratinocytes (HEK) and human dermal fibroblasts (HDF) of the three scaffolds with varying ibuprofen concentrations were evaluated and compared to pure PLA nanofibrous scaffolds. Thereafter, scaffolds loaded with ibuprofen at the concentration that promoted human skin cell viability and proliferation (20 wt %) were evaluated in vivo in nude mice using a full thickness skin incision model to determine the ability of these scaffolds to promote skin regeneration and/or assist with scarless healing. Both acellular and HEK and HDF cell-seeded 20 wt % ibuprofen loaded nanofibrous bandages reduced wound contraction compared with wounds treated with Tegaderm™ and sterile gauze. Newly regenerated skin on wounds treated with cell-seeded 20 wt % ibuprofen bandages exhibited significantly greater blood vessel formation relative to acellular ibuprofen bandages. We have found that degradable anti-inflammatory scaffolds containing 20 wt % ibuprofen promote human skin cell viability and proliferation in vitro, reduce wound contraction in vivo, and when seeded with skin cells, also enhance new blood vessel formation. The approaches and results reported here hold promise for multiple skin tissue engineering and wound healing applications. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 327-339, 2017.
Strategic Challenges for Application Development Productivity in Reconfigurable Computing (2008)

Performance and versatility requirements arising from escalating fabrication costs and design complexities are making reconfigurable computing technologies increasingly advantageous on the roadmap towards many-core technologies. This reformation in device architectures is necessitating a critical reformation in application design methods to bridge the widening semantic gap between design productivity and execution efficiency. This paper explores the strategic challenges in FPGA design methodologies and evaluates potential solutions and their impact on future DoD applications and users. A new research initiative, strategic infrastructure for reconfigurable computing applications (SIRCA), has also been proposed as a potential new DARPA program to address the FPGA productivity problem.
Microwave-Accelerated Ultrafast Nanoparticle Aggregation Assays Using Gold Colloids (2007)

In this paper, the proof of principle of microwave-accelerated aggregation assay technology, which shortens the solution-based aggregation assays' run time to seconds (>100-fold increase in kinetics) with microwave heating, was demonstrated using a model aggregation assay based on the well-known interactions of biotin and avidin. Biotinylated gold colloids were aggregated in solution with the addition of streptavidin, which takes 20 min at room temperature to reach >90% completion and only 10 s with microwave heating. The initial velocity (after 1-s microwave heating) of the biotinylated gold colloids reaches up to 10.5 m/s, which gives rise to greater sampling of the total volume but not a large increase in bulk temperature. The room-temperature, steady-state velocity of the colloids was <0.5 microm/s. In control experiments, where streptavidin preincubated with d-biotin in solution is added to biotinylated gold colloids and microwave heated, gold colloids did not aggregate, demonstrating that nonspecific interactions between biotinylated gold colloids and streptavidin were negligible.
Lipid composition but not curvature is a determinant of a low molecular mobility within HIV-1 lipid envelope (2018)

Abstract Human Immunodeficiency Virus type-1 (HIV-1) acquires its lipid membrane from the plasma membrane of the infected cell from where it buds out. Previous studies have shown that the HIV-1 envelope is a very low mobility environment with the diffusion of incorporated proteins two orders of magnitude slower than in plasma membrane. One of the reasons for this difference is thought to be due to HIV-1 membrane composition that is characterised by a high degree of rigidity and lipid packing. To further refine the model of the molecular mobility on HIV-1 surface, we here investigated the relative importance of membrane composition and curvature in Large Unilamellar Vesicles of different composition and size (0.2–1 μm) by super-resolution STED microscopy-based fluorescence correlation spectroscopy (STED-FCS) analysis. We find that lipid composition and its rigidity but not membrane curvature play an important role in the decreased molecular mobility on vesicle surface thus confirming that this factor is an essential determinant of HIV-1 low surface mobility. Our results provide further insight into the dynamic properties of the surface of individual HIV-1 particles.
A study of academic collaboration in computational linguistics with latent mixtures of authors (2011)

Academic collaboration has often been at the forefront of scientific progress, whether amongst prominent established researchers, or between students and advisors. We suggest a theory of the different types of academic collaboration, and use topic models to computationally identify these in Computational Linguistics literature. A set of author-specific topics are learnt over the ACL corpus, which ranges from 1965 to 2009. The models are trained on a per year basis, whereby only papers published up until a given year are used to learn that year’s author topics. To determine the collaborative properties of papers, we use, as a metric, a function of the cosine similarity score between a paper’s term vector and each author’s topic signature in the year preceding the paper’s publication. We apply this metric to examine questions on the nature of collaborations in Computational Linguistics research, finding that significant variations exist in the way people collaborate within different subfields. 1
Realization and Scaling of ${\rm Ge}{\hbox{--}}{\rm Si}_{1{\hbox{-}}{\rm x}}{\rm Ge}_{\rm x}$ Core-Shell Nanowire $n$-FETs (2013)

We present the realization and scaling properties of germanium-silicon-germanium (Ge-Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</sub> Ge <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> ) core-shell nanowire (NW) n-type, Ω-gate field-effect transistors (FETs). The devices show superior performance to the counterparts without the Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</sub> Ge <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> shell. With a channel length (L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ch</sub> ) of 380 nm and a diameter of 40 nm, we demonstrate a subthreshold swing of 180 mV/dec, and an ON-current (ION) of 60 μA/μm, comparable with recent results in Ge n-type FinFETs fabricated by top-down techniques. By systematically studying the scaling properties, we identify the contribution of the channel and contact resistances to device characteristics. We conclude that I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ON</sub> is not limited by the contact resistance but rather by a relatively large channel resistance, presumably associated with a high-interface trap density (D <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">it</sub> ).
Optimal Dissociation Methods Differ for N- and O-glycopeptides (2020)

Site-specific characterization of glycosylation requires intact glycopeptide analysis, and recent efforts have focused on how to best interrogate glycopeptides using tandem mass spectrometry (MS/MS). Beam-type collisional activation, i.e., higher-energy collisional dissociation (HCD), has been a valuable approach, but stepped collision energy HCD (sceHCD) and electron transfer dissociation with HCD supplemental activation (EThcD) have emerged as potentially more suitable alternatives. Both sceHCD and EThcD have been used with success in large-scale glycoproteomic experiments, but they each incur some degree of compromise. Most progress has occurred in the area N-glycoproteomics. There is growing interest in extending this progress to O-glycoproteomics, which necessitates comparisons of method performance for the two classes of glycopeptides. Here, we systematically explore the advantages and disadvantages of conventional HCD, sceHCD, ETD, and EThcD for intact glycopeptide analysis and determine their suitability for both N- and O-glycoproteomic applications. For N-glycopeptides, HCD and sceHCD generate similar numbers of identifications, although sceHCD generally provides higher quality spectra. Both significantly outperform EThcD methods, indicating that ETD-based methods are not required for routine N-glycoproteomics. Conversely, ETD-based methods, especially EThcD, are indispensable for site-specific analyses of O-glycopeptides. Our data show that O-glycopeptides cannot be robustly characterized with HCD-centric methods that are sufficient for N-glycopeptides, and glycoproteomic methods aiming to characterize O-glycopeptides must be constructed accordingly.
Comparative Molecular and Immunoregulatory Analysis of Extracellular Vesicles from Candida albicans and Candida auris (2021)

Candida auris is a recently described multidrug-resistant pathogenic fungus that is increasingly responsible for health care-associated outbreaks across the world. Bloodstream infections of this fungus cause death in up to 70% of cases. Aggravating this scenario, the disease-promoting mechanisms of C. auris are poorly understood. Fungi release extracellular vesicles (EVs) that carry a broad range of molecules, including proteins, lipids, carbohydrates, pigments, and RNA, many of which are virulence factors. Here, we carried out a comparative molecular characterization of C. auris and Candida albicans EVs and evaluated their capacity to modulate effector mechanisms of host immune defense. Using proteomics, lipidomics, and transcriptomics, we found that C. auris released EVs with payloads that were significantly different from those of EVs released by C. albicans. EVs released by C. auris potentiated the adhesion of this yeast to an epithelial cell monolayer, while EVs from C. albicans had no effect. C. albicans EVs primed macrophages for enhanced intracellular yeast killing, whereas C. auris EVs promoted survival of the fungal cells. Moreover, EVs from both C. auris and C. albicans induced the activation of bone marrow-derived dendritic cells. Together, our findings show distinct profiles and properties of EVs released by C. auris and by C. albicans and highlight the potential contribution of C. auris EVs to the pathogenesis of this emerging pathogen. <b>IMPORTANCE</b> Candida auris is a recently described multidrug-resistant pathogenic fungus that is responsible for outbreaks across the globe, particularly in the context of nosocomial infections. Its virulence factors and pathogenesis are poorly understood. Here, we tested the hypothesis that extracellular vesicles (EVs) released by C. auris are a disease-promoting factor. We describe the production of EVs by C. auris and compare their biological activities against those of the better-characterized EVs from C. albicans. C. auris EVs have immunoregulatory properties, of which some are opposite those of C. albicans EVs. We also explored the cargo and structural components of those vesicles and found that they are remarkably distinct compared to EVs from C. auris's phylogenetic relative Candida albicans.
Neural Audio Captioning Based on Conditional Sequence-to-Sequence Model (2019)

We propose an audio captioning system that describes non-speech audio signals in the form of natural language. Unlike existing systems, this system can generate a sentence describing sounds, rather than an object label or onomatopoeia. This allows the description to include more information, such as how the sound is heard and how the tone or volume changes over time, and can accommodate unknown sounds. A major problem in realizing this capability is that the validity of the description depends not only on the sound itself but also on the situation or context. To address this problem, a conditional sequence-to-sequence model is proposed. In this model, a parameter called "specificity" is introduced as a condition to control the amount of information contained in the output text and generate an appropriate description. Experiments show that the model works effectively.
Manufacture and testing of the superconducting wire and cable for the RHIC dipoles and quadrupoles (1995)

Production of superconducting wire and cable for the Relativistic Heavy Ion Collider (RHIC) dipoles and quadrupoles is now complete. This report presents the final statistics generated during the manufacture and testing of this cable.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
High dose epinephrine in refractory pediatric cardiac arrest (1989)

Cardiac arrest has a poor prognosis, regardless of age group. Children who fail to respond to two standard doses of epinephrine (0.01 mg/kg) rarely survive to hospital discharge, and most die without the return of spontaneous circulation (ROSC). We treated seven consecutive children in cardiac arrest with high dose epinephrine (0.2 mg/kg) after failure to respond to two standard doses. Six had prompt and sustained ROSC. By comparison, in the previous 20 consecutive pediatric patients with cardiac arrest in which there was no response to two standard doses of epinephrine, none had ROSC. Previous animal data as well as anecdotal human experience suggest that the standard epinephrine dose (0.01 mg/kg) may be much too low.