gebhart/patrepeval huggingface dataset:
The Functions of Clusterin Expression in Renal Mesenchymal Stromal Cells: Regulation of Cell Proliferation and Macrophage Activation (2021)

Abstract The expression of clusterin (CLU) in mice increases resistance to renal ischemia-reperfusion injury and promotes renal tissue repair. However, the mechanisms underlying of the renal protection of CLU remain largely unknown. Mesenchymal stromal cells (MSCs), found in different compartments of the kidney, may contribute to kidney cell turnover and injury repair. This study investigated the in vitro functions of CLU in kidney mesenchymal stromal cells (KMSCs). KMSCs were isolated by digestion of kidney tissues with collagenase type 1 and growth in plastic culture plates. Cell surface markers, apoptosis and phagocytosis were determined by flow cytometry, and CLU protein by Western blot. Here, we showed that KMSCs isolated from both wild type (WT) and CLU knockout (KO) mice positively expressed CD133, Sca-1, CD44, and CD117, and negatively of CD34, CD45, CD163, CD41, CD276, CD138 and CD79a. There was no difference in trilineage differentiation to chondrocytes, adipocytes and osteocytes between WT and KO KMSCs. CLU protein was expressed in and secreted by WT KMSCs, and it was up-regulated in response to hypoxia. However, lack of CLU expression did not negatively affect hypoxia-induced apoptosis in cultured KMSCs. The WT KMSCs proliferated faster than KO KMSCs in cultures. Furthermore, the incubation of macrophages with CLU-containing culture medium from WT KMSCs increased the CD206 expression in the macrophages and their phagocytic capacity. In conclusion, our data for the first time demonstrate the functions of CLU in the promotion of KMSCs proliferation, and may be required for KMSCs-regulated macrophage M2 polarization and phagocytic activity.
Human rheumatoid factor cross‐idiotypes (1990)

The BLA cross-idiotype (XId) is present on a unique subset of rheumatoid factors (RF) that cross-react with DNA-histone. In this study, prototype Bla monoclonal RF was shown from serologic investigations and N-terminal amino acid sequence analysis to have distinct kappa chains related to the V kappa III subgroup and VH4 heavy chains. The amino terminus of the heavy chain was cyclized, rendering the protein resistant to Edman degradation and providing a possible investigator bias to the published Ig sequence data to date. This appears to be the first definitive report of a serum IgM that expresses the VH4 gene. RF with DNA cross-reactivity have been reported to be produced by human and mouse cloned cells that have the VH4 or homologous mouse Vh36-60 gene.
Trifunctional Reagents in Organic Synthesis: Sequential, Chemoselective Reactions Leading to the Preparation of Structurally Novel Tricycles (2000)

The synthetic utility of the structurally novel trifunctional reagents 11-13 is described. Using 11-13 and the 3-isobutoxycyclohex-2-en-1-ones 14 and 28 as starting materials, the enones 18-20 and 31-33 are readily prepared. Copper(I) cyanide-mediated intramolecular conjugate addition of each of these enones provides good-to-excellent yields of the corresponding bicyclo[4.3.0]non-8-en-3-ones 21-23 and 34-36. Intramolecular alkylation of the latter substances affords the structurally novel tricyclic ketones 24-26 and 37-39, respectively, in high yields.
Direct Catalytic Enantioselective α‐Aminomethylation of Aldehydes. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Structure and Magnetism of the Tetra‐Copper(II)‐Substituted Heteropolyanion [Cu4K2(H2O)8 (α‐AsW9O33)2]8‐. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Chronic hepatitis E virus infection in a patient with leukemia and elevated transaminases: a case report (2012)

Usually, hepatitis E virus infection appears as an acute infection; rare chronic infections have been reported for transplant patients, patients with human immunodeficiency virus, and patients with hematological malignancies. The chronic nature of hepatitis E infection in our patient was most likely induced by the immunosuppressive B-cell chronic lymphocytic leukemia treatment. The differential diagnosis in patients with unexplained hepatitis should include hepatitis E virus infection, and appropriate laboratory analyses should be considered.
2. The Latest Trend of Organic CMOS Image Sensors (2018)

近年，CMOS イメージセンサ (CMOS Image Sensor: CIS) は，高解像度，高フレームレート，高感度といった特長で CCD に替わって撮像素子の主流となってきた．しかしなが ら通常の CIS では，露光やシャッタ動作を行毎に順次走査 し行うローリングシャッタ動作を伴う．CCD 同様の画像歪 みの生じないグローバルシャッタ動作には画素部にメモ リーの追加が必要となり，受光面積縮小による飽和電荷量 の減少などから限られた用途に留まっていた 1) -3) ． また，センシング分野ではワイドダイナミックレンジ (Wide Dynamic Range: WDR) に加えて不可視情報を捉え ることのできるイメージセンサも望まれている．近赤外光 (near-infrared: NIR) などを用いて取得したセンシング結 果を可視画像と組合せれば，距離情報や分光情報を色情報 に付与することができる． これら次世代のイメージセンサに求められる性能を実現 する技術として，筆者らで開発している有機 CMOS イメー ジセンサの最新動向を紹介する． ２．有機 CMOS イメージセンサの画素構造と 光電変換の原理 筆者らで開発している有機CISの画素断面模式図を図1 (a) に示す．有機光電変換膜 (Organic Photoconductive Film: OPF) を読出し回路の設けられた CMOS チップ上に積層し た構造となっており，それぞれを独立した領域に形成可能 なことから，受光面積の圧迫なく広い回路領域を得ること ができる．センサに入射した光は画素毎に設けられたマイ クロレンズ，カラーフィルタを介して OPF に吸収され，電 子正孔対が生成される．発生した正孔は OPF に印加される 電界強度に応じて画素電極側に引き抜かれ，信号電荷とし てシリコン (Si) 基板上に形成した浮遊拡散層 (Floating Diffusion: FD) に蓄積される．OPF の感度は図 1 (b) に示す ように，OPF 上部の透明電極 (Indium Tin Oxide: ITO) に 印加する電圧 (V ITO) により制御することが可能である．筆 者らは，この特有の積層構造と，電圧により光電変換特性 を制御可能な点に注目して技術開発を行っている． ３．123 dB
Laminated Thin Li-Ion Batteries Using LiNi<sub>0.8−y</sub>Co<sub>0.2</sub>Al<sub>y</sub>O<sub>2</sub> Cathode Materials (2003)

Thermal stability, surface characteristics, and electrode performance for LiNi1−x−yCoxAlyO2-based materials in a 1.5 M LiBF4 ethylene carbonate/γ-butyrolactone (1: 2) electrolyte have been investigated in order to develop laminated thin Li-ion batteries using LiNi0.8−yCo0.2AlyO2 cathodes. Using a LiNi0.74Co0.2Al0.06O2 cathode with low basicity, the laminated thin Li-ion batteries provided high energy density, long cycle life, and very low swelling. It was demonstrated that the prototype laminated thin Li-ion battery with a thickness of 3.8 mm achieved the energy densities of 200 Wh/kg and 407 Wh/l. The value of pH (definition is in experimental section) for LiNi0.74Co0.2Al0.06O2 should be less than 11 for the practical application because of a long cycle life of 500 cycles and very low swelling at an even high temperature of 85°C. Native alkaline impurities in LiNi0.8−yCo0.2AlyO2 led to CO2 gas evolution and cycle degradation. The results of impedance and x-ray photoelectron spectroscopy measurements for LiNi0.74Co0.2Al0.06O2 and LiCoO2 indicated that the surface film formation on LiNi0.74Co0.2Al0.06O2 cathode is more inactive and thermally stable than that of LiCoO2 cathode. The films formation on LiNi0.8−yCo0.2AlyO2 cathode suppressed further oxidation of the electrolyte and the gas evolution at high-temperature condition.
Optimizing two-phase, level-clocked circuitry (1997)

We investigate two strategies for reducing the clock period of a two-phase, level-clocked circuit: clock tuning, which adjusts the waveforms that clock the circuit, and retiming, which relocates circuit latches. These methods can be used to convert a circuit with edge-triggered latches into a faster level-clocked one.
ChemInform Abstract: Regioselectivity in Electrophilic Substitution of 5‐Aminoindoles and 5‐ Aminoindolines: Synthesis of Pyrrolo(3,2‐e)indoles and Isomeric Pyrrolo(2,3‐f)indoles. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Analysis of the Efficiency of Surfactant-Mediated Stabilization Reactions of EGaIn Nanodroplets (2017)

A methodology based on light scattering and spectrophotometry was developed to evaluate the effect of organic surfactants on the size and yield of eutectic gallium/indium (EGaIn) nanodroplets formed in organic solvents by ultrasonication. The process was subsequently applied to systematically evaluate the role of headgroup chemistry as well as polar/apolar interactions of aliphatic surfactant systems on the efficiency of nanodroplet formation. Ethanol was found to be the most effective solvent medium in promoting the formation and stabilization of EGaIn nanodroplets. For the case of thiol-based surfactants in ethanol, the yield of nanodroplet formation increased with the number of carbon atoms in the aliphatic part. In the case of the most effective surfactant system-octadecanethiol-the nanodroplet yield increased by about 370% as compared to pristine ethanol. The rather low overall efficiency of the reaction process along with the incompatibility of surfactant-stabilized EGaIn nanodroplets in nonpolar organic solvents suggests that the stabilization mechanism differs from the established self-assembled monolayer formation process that has been widely observed in nanoparticle formation.
Evaluating interactive dialogue systems (1997)

This paper discusses the range of ways in which spoken dialogue system components have been evaluated and discusses approaches to evaluation that attempt to integrate component evaluation into an overall view of system performance. We will argue that the PARADISE (PARAdigm for DIalogue System Evaluation) framework has several advantages over other proposals.
Long-Wavelength High-Contrast Grating Vertical-Cavity Surface-Emitting Laser (2010)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> A novel long-wavelength vertical-cavity surface-emitting laser (VCSEL) structure based on a subwavelength high-contrast grating (HCG) as the output mirror has been realized. By design, these devices are highly polarization stable, are single mode at large apertures, and solve the VCSEL-mirror problem at long wavelengths in an elegant way. With cost-effective mass fabrication in mind, the top HCG reflector consists of amorphous silicon on isolator (amorphous silica). The single-mode laser emission is tailored to be around 1320-nm wavelength, targeting applications in high-speed optical data transmission, particularly those for passive optical networks. We report single-mode emission for devices with apertures as large as 11 <formula formulatype="inline"><tex Notation="TeX">$\mu\hbox{m}$</tex> </formula> operating in continuous wave with output powers in excess of 0.4 mW. Pulsed operation with output powers up to 4 mW at room temperature is demonstrated as well. This is the first electrically pumped VCSEL structure realized in this wavelength regime utilizing an HCG mirror. </para>
Overloaded Satellite Receiver Using SIC with Hybrid Beamforming and ML\n Detection (2014)

In this paper, a new receiver structure that is intended to detect the\nsignals from multiple adjacent satellites in the presence of other interfering\nsatellites is proposed. We tackle the worst case interference conditions, i.e.,\nit is assumed that uncoded signals that fully overlap in frequency arrive at a\nmultiple-element small-size parabolic antenna in a spatially correlated noise\nenvironment. The proposed successive interference cancellation (SIC) receiver,\ndenoted by SIC Hy/ML, employs hybrid beamforming and disjoint maximum\nlikelihood (ML) detection. Depending on the individual signals spatial\nposition, the proposed SIC Hy/ML scheme takes advantage of two types of\nbeamformers: a maximum ratio combining (MRC) beamformer and a compromised array\nresponse (CAR) beamformer. The performance of the proposed receiver is compared\nto an SIC receiver that uses only MRC beamforming scheme with ML detection for\nall signals, a joint ML detector, and a minimum mean square error detector. It\nis found that SIC Hy/ML outperforms the other schemes by a large margin.\n
Harsh Environment Pressure Transducers Employing Metal Diaphragms and Silicon on Insulator Sensing Networks for Gas Turbine Application (2008)

It has long been necessary in many applications to measure pressure in extremely harsh environments at elevated temperatures. Examples of such applications include: gas turbine engines (both ground-based and for aircraft), automotive combustion, and down-hole applications for gas and oil industry. This paper reports on the latest developments of metal diaphragm transducers with Silicon-On-Insulator (SOI) piezoresistive sensor networks for ultra extreme environments. The design of the latest Inconel-diaphragm miniature, dynamic pressure transducers capable of operating reliably under extreme environmental conditions (temperatures up to 500°C and accelerations greater than 200g) — is described in detail. The performance of such metal diaphragm pressure transducers is presented and indicates that ruggedized, piezoresistive transducers with excellent static and dynamic performance characteristics are capable of operation in extremely harsh, high temperature gas turbine environments.
Correlating Social Interconnections of Users with Spatio-Temporal Check-Ins Behavior (2016)

Acquiring the knowledge about the relationship among friendship network properties and check-in behavior of users (connected in the friendship network) has several benefits such as planning advertising strategies and recommending the friends or places. This paper aims to find the impact of structural patterns hidden in the nodes of a friendship network and external environment changes in the check-in patterns of the users. First, we categorize each spatial check-in event based on its cause into either self reinforcing behavior or social influence or external effect. Then, we explore how network and spatial properties and external factors affect the number of check-ins and influences. Using check-ins data from four major cities/states and its users' friendship graph, we show how network and spatial properties like centrality, network neighborhood overlap, spatial check-ins overlap, strong ties effects the check-ins and influential behavior of individuals.
A prospective randomized study comparing intramuscular with intravaginal natural progesterone in programmed thaw cycles (1999)

A simple programmed thaw cycle is described, during which the endometrium is prepared with oral oestradiol, followed by a natural progesterone source. This method involves minimal blood tests and uses inexpensive medications. Originally, an i.m. progesterone-in-oil preparation was used. Although highly successful in achieving high serum progesterone concentrations, the daily injections of the oily compound were found to be problematic from the patients' perspective. To examine the possibility of replacing the injectable progesterone with a vaginal preparation we conducted a prospective randomized study of 1 year's duration, during which time 170 and 184 thawing cycles were done with injectable and vaginal progesterone respectively. Although the progesterone blood concentrations obtained with the injectable preparation were more than twice those obtained with the vaginal progesterone, the clinical pregnancy rates (defined as percentage thawing cycles with gestational sac(s)/embryo transfer as demonstrated on ultrasound, 4 weeks after embryo transfer) were similar for both groups (15.9 and 16.8% respectively). Implantation and abortion rates were also comparable. These results agree with previous reports of higher uterine progesterone concentrations after the vaginal application. We conclude that the combination of oral oestradiol and vaginal progesterone is an effective, simple and inexpensive approach for programmed thaw cycles.
WIDE-BANDWIDTH COMB-ASSISTED SPECTROSCOPY IN THE FINGERPRINT REGION AND APPLICATION TO THE ν1 FUNDAMENTAL BAND OF 14N216O (2018)

Computation of the dipole moment in a ro-vibrationally averaged molecular \n\nstate of a triatomic molecule requires the 3D potential energy surface and the \n\nassociated ro-vibrational wavefunctions. Consequently, in most cases,\n\nthe experimentally derived value of the dipole moment in the ro-vibronic ground state\n\nis compared with the theoretical dipole moment value \n\nfor the ``equilibrium geometry.'' We have proposed in recent publications\\footnote{T.~Hirano, U.~Nagashima, {\\it J. Mol. Spectrosc.}, {\\bf 314}, 35--47 (2015)}$^,$%\n\n\\footnote{T.~Hirano, U.~Nagashima, P.~Jensen, {\\it J. Mol. Spectrosc.} {\\bf 343}, 54--61 (2018).}$^,$\\footnote{T.~Hirano, U.~Nagashima, P.~Jensen, {\\it J. Mol. Spectrosc.} (2018), https://doi.org/10.1016/j.jms.2017.12.011.}\n\nthat any linear molecule, whose potential energy minimum occurs \n\nat a linear configuration, is observed as being bent on ro-vibrational average. \n\nThat gives rise to the question recently asked by a reviewer of our paper:$^c$\n\n Why does the averaged dipole moment vanish for a symmetrical triatomic molecule\n\nof type ABA, such as CO$_{2}$?\n\n\n\nIn the present talk we show that there is no contradiction, for linear \n\ntriatomic molecules, between our proposition of a bent averaged geometry \n\nand the experimentally derived, vibrationally averaged dipole moment value. \n\nWe must consider two facts: 1) for a linear molecule, \n\nthe rotation about the $a$ axis, which approximately coincides with\n\nthe molecular axis, cannot be separated from the bending motion described by variation \n\nof the bond angle in the instantaneous molecular plane, and 2) the dipole moment function \n\nis an odd function of the angle describing this rotation. Therefore, only the $a$ axis component of the dipole moment can be observed (and it, too, vanishes by symmetry for an ABA molecule).\n\n\n\nTaking CO$_{2}$ and HCO$^{+}$ as examples, \n\nwe show, from the theoretical view point, how the dipole moment is observed \n\nin the experimental study, typically in Stark spectroscopy. \n\nOur theoretically predicted dipole moment value for the ro-vibronic ground state of HCO$^{+}$, 3.933~D, is in good agreement with that determined from Stark experiments,\\footnote{B.~J.~Mount, M.~Redshaw, E.~G.~Myers, {\\it Phys. Rev. A}, {\\bf 85}, 012519 (2012).} 3.921(31)~D (quoted uncertainty in parentheses, in units of the last digit).
Intermolecular Acetal-Initiated Cationic Polyene Cyclizations (2007)

This report describes the intermolecular acetal-initiated polyene cyclization induced by SnCl4. The authors do a nice job in optimizing the reaction and find a chiral templated acetal that allows for considerably high dr values. The absolute and relative stereochemistry were determined for the products through derivatization and X-ray crystallography. Some of the cyclization products were also functionalized to various terpenes. Importantly, this report does not require the sometimes difficult and tedious incorporation of the acetal into the cyclization precursor.
Lithium/ammonia cleavage of the nitrogen-nitrogen bond in N-(methoxycarbonyl)- and N-acetylhydrazines (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLithium/ammonia cleavage of the nitrogen-nitrogen bond in N-(methoxycarbonyl)- and N-acetylhydrazinesScott E. Denmark, Olivier Nicaise, and James P. EdwardsCite this: J. Org. Chem. 1990, 55, 25, 6219–6223Publication Date (Print):December 1, 1990Publication History Published online1 May 2002Published inissue 1 December 1990https://pubs.acs.org/doi/10.1021/jo00312a034https://doi.org/10.1021/jo00312a034research-articleACS PublicationsRequest reuse permissionsArticle Views519Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Long-term ECG trends in atherosclerotic mouse subjects (2005)

The double-knockout (dKO) mouse model, with homozygous null encoding for the apoE lipoprotein molecule and SRB-I receptor, shows extremely elevated LDL and severely depressed HDL levels in blood serum. The subjects show 100% mortality by the age of 8 weeks, with accompanying cardiac hypertrophy, reduced ejection fraction and high incidence of atherosclerosis and multiple regions of myocardial infarct noted on necropsy. While these gross observations have been published previously, we now present long-term ECG trends of these subjects. Of specific note in the dKO subjects are the appearance of severe bradycardia during the night and early morning; high-amplitude ultradian rhythm fluctuations relative to wild-type mice; ST-segment elevation and depression; and an array of ECG anomalies ranging from bigeminy to 2nd and 3rd degree heart block. While the dKO mice can, and periodically do, experience self-limited episodes of ventricular tachycardia and subsequent fibrillation, the small size of the heart makes sustained re-entry and fibrillation impossible (in accordance with the critical mass hypothesis). Our study of 11 dKO subjects indicates that these subjects are not suffering a tachyarrhythmic death, but rather a progressive bradyarrhythmia and terminal asystolic cardiac arrest
Robust Task-Specific Beamforming with Low-Resolution ADCs for Power-Efficient Hybrid MIMO Receivers (2022)

Multiple-input multiple-output (MIMO) systems exploit spatial diversity to facilitate multi-user communications with high spectral efficiency by beamforming. As MIMO systems utilize multiple antennas and radio frequency (RF) chains, they are typically costly to implement and consume high power. A common method to reduce the cost of MIMO receivers is utilizing less RF chains than antennas by employing hybrid analog/digital beamforming (HBF). However, the added analog circuitry involves active components whose consumed power may surpass that saved in RF chain reduction. An additional method to realize power-efficient MIMO systems is to use low-resolution analog-to-digital converters (ADCs), which typically compromises signal recovery accuracy. In this work, we propose a power-efficient hybrid MIMO receiver with low-quantization rate ADCs, by jointly optimizing the analog and digital processing in a hardware-oriented manner using task-specific quantization techniques. To mitigate power consumption on the analog front-end, we utilize efficient analog hardware architecture comprised of sparse low-resolution vector modulators, while accounting for their properties in design to maintain recovery accuracy and mitigate interferers in congested environments. To account for common mismatches induced by non-ideal hardware and inaccurate channel state information, we propose a robust mismatch aware design. Supported by numerical simulations and power analysis, our power-efficient MIMO receiver achieves comparable signal recovery performance to power-hungry fully-digital MIMO receivers using high-resolution ADCs. Furthermore, our receiver outperforms the task-agnostic HBF receivers with low-rate ADCs in recovery accuracy at lower power and successfully copes with hardware mismatches.