gebhart/patrepeval huggingface dataset:
Bimetallic iron–iron and iron–zinc complexes of the redox-active ONO pincer ligand (2015)

A new bimetallic platform comprising a six-coordinate Fe(ONO)<sub>2</sub> unit bound to an (ONO)M (M = Fe, Zn) has been discovered ((ONO<sup>cat</sup>)H<sub>3</sub> = bis(3,5-di-<i>tert</i>-butyl-2-phenol)amine). Reaction of Fe(ONO)<sub>2</sub> with either (ONO<sup>cat</sup>)Fe(py)<sub>3</sub> or with (ONO<sup>q</sup>)FeCl<sub>2</sub> under reducing conditions led to the formation of the bimetallic complex Fe<sub>2</sub>(ONO)<sub>3</sub>, which includes unique five- and six-coordinate iron centers. Similarly, the reaction of Fe(ONO)<sub>2</sub> with the new synthon (ONO<sup>sq</sup>˙)Zn(py)<sub>2</sub> led to the formation of the heterobimetallic complex FeZn(ONO)<sub>3</sub>, with a six-coordinate iron center and a five-coordinate zinc center. Both bimetallic complexes were characterized by single-crystal X-ray diffraction studies, solid-state magnetic measurements, and multiple spectroscopic techniques. The magnetic data for FeZn(ONO)<sub>3</sub> are consistent with a ground state <i>S</i> = 3/2 spin system, generated from a high-spin iron(ii) center that is antiferromagnetically coupled to a single (ONO<sup>sq</sup>˙)<sup>2-</sup> radical ligand. In the case of Fe<sub>2</sub>(ONO)<sub>3</sub>, the magnetic data revealed a ground state <i>S</i> = 7/2 spin system arising from the interactions of one high-spin iron(ii) center, one high-spin iron(iii) center, and two (ONO<sup>sq</sup>˙)<sup>2-</sup> radical ligands.
Role of Complement in Immune Regulation and Its Exploitation by Virus (2007)

Complement is activated during the early phase of viral infection and promotes destruction of virus particles as well as the initiation of inflammatory responses. Recently, complement and complement receptors have been reported to play an important role in the regulation of innate as well as adaptive immune responses during infection. The regulation of host immune responses by complement involves modulation of dendritic cell activity in addition to direct effects on T-cell function. Intriguingly, many viruses encode homologs of complement regulatory molecules or proteins that interact with complement receptors on antigen-presenting cells and lymphocytes. The evolution of viral mechanisms to alter complement function may augment pathogen persistence and limit immune-mediated tissue destruction. These observations suggest that complement may play an important role in both innate and adaptive immune responses to infection as well as virus-mediated modulation of host immunity.
ZrO2 Monolayer as a Removable Etch Stop Layer for Thermal Al2O3 Atomic Layer Etching Using Hydrogen Fluoride and Trimethylaluminum (2020)

A ZrO2 monolayer was demonstrated as a removable etch stop layer (ESL) for thermal Al2O3 atomic layer etching (ALE) using HF and Al(CH3)3 (trimethylaluminum (TMA)) as the reactants. The ZrO2 ESL was deposited on Al2O3 using tetrakis(ethylmethylamido)zirconium (TEMAZ) and H2O. In situ quartz crystal microbalance (QCM) measurements showed that a ZrO2 coverage of ∼190 ng/cm2 completely blocked thermal Al2O3 ALE at 285 °C. This ZrO2 coverage is equivalent to approximately one ZrO2 monolayer. The inhibition of the Al2O3 etch rate was proportional to the ZrO2 fractional coverage. The ZrO2 ESL was effective for hundreds of thermal Al2O3 ALE cycles. In terms of the surface chemistry, the ZrO2 ESL is known to be fluorinated to a ZrOxFy or ZrF4 layer by HF exposure. This fluorinated layer restricts etching by preventing the ligand-exchange reaction with TMA. The fluorinated layer could be easily removed using thermal ALE with HF and AlCl(CH3)2 (dimethylaluminum chloride (DMAC)) as the reactants. The ZrO2 ESL could be deposited and removed repeatedly without changing the Al2O3 etch rate. X-ray photoelectron spectroscopy (XPS) studies observed no trace of Zr on the Al2O3 surface after 7–8 cycles of HF and DMAC sequential exposures. Area selective deposition of the ZrO2 ESL would lead to area selective etching using HF and TMA as the reactants.
A randomized double‐blind placebo controlled phase I–II study on clinical and molecular effects of dietary supplements in men with precancerous prostatic lesions. Chemoprevention or “chemopromotion”? (2015)

Administration of high doses of lycopene, GTCs, and selenium in men harboring HGPIN and/or ASAP was associated with a higher incidence of PCa at re-biopsy and expression of microRNAs implicated in PCa progression at molecular analysis. The use of these supplements should be avoided.
Screening and Beyond: New Opportunities to Advance Neuroscience Discovery (2010)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTScreening and Beyond: New Opportunities to Advance Neuroscience DiscoveryCraig LindsleyCite this: ACS Chem. Neurosci. 2010, 1, 2, 84Publication Date (Web):February 17, 2010Publication History Published online17 February 2010Published inissue 17 February 2010https://pubs.acs.org/doi/10.1021/cn1000028https://doi.org/10.1021/cn1000028editorialACS PublicationsCopyright © 2010 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views760Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (614 KB) Get e-AlertscloseSUBJECTS:Drug discovery,Neuroscience,Probes,Screening assays,Therapeutics Get e-Alerts
Immortal polymerization of .epsilon.-caprolactone initiated by aluminum porphyrin in the presence of alcohol (1987)

ADVERTISEMENT RETURN TO ISSUEPREVarticleNEXTImmortal polymerization of .epsilon.-caprolactone initiated by aluminum porphyrin in the presence of alcoholMasato Endo, Takuzo Aida, and Shohei InoueCite this: Macromolecules 1987, 20, 12, 2982–2988Publication Date (Print):May 1, 1987Publication History Published online1 May 1987Published inissue 1 May 1987https://pubs.acs.org/doi/10.1021/ma00178a005https://doi.org/10.1021/ma00178a005research-articleACS PublicationsCopyright © 1987 American Chemical SocietyRequest reuse permissionsArticle Views1028Altmetric-Citations196LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A systematic review of clinical prediction rules to predict hospitalisation in children with lower respiratory infection in primary care and their validation in a new cohort (2021)

<b>Background:</b> Our goal was to identify existing clinical prediction rules for predicting hospitalisation due to lower respiratory tract infection (LRTI) in children in primary care, guiding antibiotic therapy. A validation of these rules was then performed in a novel cohort of children presenting to primary care in Malawi with World Health Organisation clinically defined pneumonia. <b>Methods:</b> MEDLINE & EMBASE databases were searched for studies on the development, validation and clinical impact of clinical prediction models for hospitalisation in children with lower respiratory tract infection between January 1<sup>st</sup>1946-June 30<sup>th</sup> 2021. Two reviewers screened all abstracts and titles independently. The study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews & Meta-Analyses guidelines. The BIOTOPE cohort (BIOmarkers TO diagnose PnEumonia) recruited children aged 2-59 months with WHO-defined pneumonia from two primary care facilities in Mzuzu, Malawi. Validation of identified rules was undertaken in this cohort. <b>Findings:</b> 1023 abstracts were identified. Following the removal of duplicates, a review of 989 abstracts was conducted leading to the identification of one eligible model. The CHARMS checklist for prediction modelling studies was utilized for evaluation. The area under the curve (AUC) of the STARWAVe rule for hospitalisation in BIOTOPE was found to be 0.80 (95% C.I of 0.75-0.85). The AUC of STARWAVe for a confirmed diagnosis of bacterial pneumonia was 0.39 (95% C.I 0.25-0.54). <b>Interpretation:</b> This review highlights the lack of clinical prediction rules in this area. The STARWAVe rule identified was useful in predicting hospitalisation from bacterial infection as defined. However, in the absence of a gold standard indicator for bacterial LRTI, this is a reasonable surrogate and could lead to reductions in antibiotic prescription rates, should clinical impact studies prove its utility. Further work to determine the clinical impact of STARWAVe and to identify diagnostic tests for bacterial LRTI in primary care is required.
Supplementary Figure Legends, Tables and Methods from The Combined Effect of FGFR Inhibition and PD-1 Blockade Promotes Tumor-Intrinsic Induction of Antitumor Immunity (2023)

&lt;p&gt;Supplemental figure legends 1-8, Supplementary tables 1-5, and Supplementary methods&lt;/p&gt;
Charge Selectivity of Rat Intestinal Capillaries (1986)

Abstract The role of fixed anionic sites on the intestinal capillary wall in transvascular protein exchange was assessed by neutralizing the negative charges with polycations. The studies were performed in anesthetized rats with an intestinal lymph cannula. Intestinal lymph flow and lymph and plasma total protein concentrations were measured at regular intervals before and after intravenous infusion of either protamine sulfate, poly-l-lysine, or polyethyleneimine. Protamine sulfate infusion produced an eightfold increase in lymph flow and a fivefold increase in lymph protein clearance. Lymph flow increased 4.6-fold and lymph protein clearance increased 3.6 times over control in rats receiving the poly-l-lysine infusion. Polyethyleneimine infusion produced results comparable in magnitude to protamine sulfate; however, the animals were unable to tolerate this agent. The enhanced transcapillary protein fluxes produced by the polycation infusions suggest that fixed anionic sites normally impede the egress of proteins from the intestinal vasculature.
Silica Immobilized Second Generation Hoveyda‐Grubbs: A Convenient, Recyclable and Storageable Heterogeneous Solid Catalyst (2008)

Abstract The second generation Hoveyda–Grubbs metathesis catalyst was successfully immobilized on silica in pellet and powder form following a practical and fast synthesis procedure. The activity of the solid system is truly heterogeneous, efficient in various metathesis reaction types and stable for at least 4000 TON. Ru contamination of the products was very low (ppb levels). The successful use of the robust system has been demonstrated in a continuous reactor set‐up.
Plasmodium falciparum MSP3 Exists in a Complex on the Merozoite Surface and Generates Antibody Response during Natural Infection (2018)

<i>Plasmodium falciparum</i> merozoite surface protein 3 (MSP3) is an abundantly expressed secreted merozoite surface protein and a leading malaria vaccine candidate antigen. However, it is unclear how MSP3 is retained on the surface of merozoites without a glycosylphosphatidylinositol (GPI) anchor or a transmembrane domain. In the present study, we identified an MSP3-associated network on the <i>Plasmodium</i> merozoite surface by immunoprecipitation of <i>Plasmodium</i> merozoite lysate using antibody to the N terminus of MSP3 (anti-MSP3N) followed by mass spectrometry analysis. The results suggested the association of MSP3 with other merozoite surface proteins: MSP1, MSP6, MSP7, RAP2, and SERA5. Protein-protein interaction studies by enzyme-linked immunosorbent assay (ELISA) and surface plasmon resonance (SPR) analysis showed that MSP3 complex consists of MSP1, MSP6, and MSP7 proteins. Immunological characterization of MSP3 revealed that MSP3N is strongly recognized by hyperimmune serum from African and Asian populations. Furthermore, we demonstrate that human antibodies, affinity purified against recombinant MSP3N (rMSP3N), promote opsonic phagocytosis of merozoites in cooperation with monocytes. At nonphysiological concentrations, anti-MSP3N antibodies inhibited the growth of <i>P. falciparum in vitro</i> Together, the data suggest that MSP3 and especially its N-terminal region containing known B/T cell epitopes are targets of naturally acquired immunity against malaria and also comprise an important candidate for a multisubunit malaria vaccine.
An Objective Criterion For The Cessation Of Deferoxamine Therapy In The Acutely Iron Poisoned Patient (1991)

The criteria for the cessation of deferoxamine therapy in the acutely iron poisoned patient are vague and imprecise. We have developed a urinary iron assay which is not confounded by the presence of deferoxamine and have established a reference range in non-iron poisoned deferoxamine treated human volunteers. When reported as a urine iron to creatinine ratio the results from isolated urine specimens can be utilized to guide deferoxamine therapy. This method is rapid, simple and inexpensive and utilizes equipment and reagents found in laboratories already providing emergency serum iron concentrations. We have found this assay to be useful as a criterion for the cessation of deferoxamine therapy in the acutely iron poisoned patient and as an objective indicator of a positive deferoxamine chelation challenge.
Anti-MRSA activity of sophoraflavanone G and synergism with other antibacterial agents (1998)

Anti-MRSA activity of sophoraflavanone G (SFG) and synergism between SFG and antibacterial agents against MRSA (methicillin-resistant Staphylococcus aureus) were evaluated by means of Minimal Inhibitory Concentrations (MIC). The MICs of SFG against 27 strains of MRSA ranged from 3.13 to 6.25 micrograms ml-1. Synergism between SFG and vancomycin hydrochloride (VCM) or fosfomycin (FOM) was observed (the fraction inhibitory concentration (FIC) indices were 0.16 and 0.48), while partial synergism was admitted between SFG and other antibacterial agents such as methicillin (DMPPC), cefzonam (CZON), gentamicin (GM), minocycline (MINO) and levofloxacin (LVFX) (the FIC indices were 0.71, 0.73, 0.69, 0.65 and 0.58, respectively). These findings suggest that SFG in combination with VCM or FOM may be useful in controlling MRSA infections.
Formula SAE electric competition: Electrical motor design (2013)

Electric mobility is becoming a growing reality due to increase of the demand and cost of oil and the environmental impact of conventional internal combustion engines. To follow this trend, national student competitions belonging to Formula SAE (Society of Automotive Engineers) series have been introduced for purely electric vehicles, in addition to those traditionally associated with internal combustion engine vehicles. On the other hand, the most promising and known electric motor candidates for traction application, represented by permanent magnet synchronous machines, are highly affected by the remarkable increase of the cost of rare earth magnet. For these reasons the research of rare-earth free alternatives, such as ferrite permanent magnet assisted synchronous reluctance motor, has potentially interesting implications especially in the perspective of industrial mass production. This paper shows the design criteria of ferrite permanent magnet assisted synchronous reluctance motors for a Formula SAE electric vehicle. The electromechanical performance have been evaluated and compared, in terms of torque and power. The most promising candidate has been finally compared with two equivalent size surface mounted permanent magnet machines: one is equipped with the same stator, while the second is characterized by a fractional slot concentrated winding. Finally, this research provides a brief description of the electric supply system in order to accurately and efficiently manage the motors for achieving the requested performance.
Characteristics of Gate-All-Around Junctionless Polysilicon Nanowire Transistors With Twin 20-nm Gates (2015)

A high performance gate-all-around (GAA) junctionless (JL) polycrystalline silicon nanowire (poly-Si NW) transistor with channel width of 12 nm, channel thickness of 45 nm, and gate length of 20 nm has been successfully demonstrated, based on a simplified double sidewall spacer process. Without suffering serious short-channel effects, the GAA JL poly-Si NW device exhibits excellent electrical characteristics, including a subthreshold swing of 105 mV/dec, a drain-induced barrier lowering of 83 mV/V, and a high I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</sub> /I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">off</sub> current ratio of 7 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8</sup> (VG = 4 V and V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sub> = 1 V). Such GAA JL poly-Si NW devices exhibit potential for low-power electronics and future 3-D IC applications.
ChemInform Abstract: FESTPHASEN‐SYNTH. VON OLIGOSACCHARIDEN 2. MITT. STERISCHE KONTROLLE DURCH C‐6‐SUBSTITUENTEN BEI GLUCOSID‐SYNTH. (1972)

Abstract Ausgehend von der Glucopyranose (I) werden durch Umsetzung mit Acylchloriden (II) die Diacylderivate (III) dargestellt (in trennbaren Gemischen mit dem entsprechenden α‐Anomeren), aus denen mit HBr die α‐D‐Glucosylbromide (IVa) erhalten werden.
Expanding the Variety of Zirconium‐based Inorganic Building Units for Metal–Organic Frameworks (2019)

Abstract Two new zirconium‐based metal–organic frameworks with the composition [Zr 6 O 4 (OH) 4 (OAc) 6 (BDC) 3 ] (CAU‐26) and [Zr 5 O 4 (OH) 4 (OAc) 4 (BDC) 2 ] (CAU‐27) are reported, which were synthesized from acetic acid, a rarely utilized but green and sustainable solvent (BDC 2− : 1,4‐benzenedicarboxylate). Structure determination aided by automated electron diffraction tomography revealed that CAU‐26 is composed of layers of well‐known {Zr 6 O 8 } clusters interconnected by terephthalate ions. In contrast CAU‐27 exhibits a three‐dimensional structure with a so far unknown type of one‐dimensional inorganic building unit (IBU), which can be rationalized as condensed polyhedron‐sharing chains of {Zr 6 O 8 } clusters. CAU‐26 occurs as an intermediate of the CAU‐27 synthesis and can be isolated easily, when reaction temperature and time are decreased. We were also able to synthesize two isoreticular derivatives of CAU‐27 with extended linker molecules by implementing 4,4′‐biphenyldicarboxylic acid (H 2 BPDC) and 5,5′‐dicarboxy‐2,2′‐bipyridine (H 2 BIPY). All materials show high thermal and chemical stability as well as permanent microporosity. The excellent stability of CAU‐27‐BIPY was exploited to synthesize a performant iridium‐supported heterogeneous MOF‐based catalyst for the direct C−H borylation of arenes.
Cost-effectiveness of low-dose colchicine after myocardial infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT) (2020)

Cost-effectiveness analyses indicate that the addition of colchicine to standard-of-care therapy after MI is economically dominant and therefore generates cost savings.
Pattern Study of Tilted Dash Mounted PCS Band and AMPS Band Antennas (2005)

PCS band and AMPS band antennas were mounted on the dashboard of an automobile. Antenna patterns toward the rear of the vehicle were measured as the antennas were tilted from the horizontal position. Results showed that for the PCS band antenna, the beam pointing angle significantly affected the frequency averaged patterns, while for the AMPS band antenna the frequency averaged patterns were minimally impacted by the antenna tilt.
Interaction of Cryptococcus neoformans Extracellular Vesicles with the Cell Wall (2014)

Cryptococcus neoformans produces extracellular vesicles containing a variety of cargo, including virulence factors. To become extracellular, these vesicles not only must be released from the plasma membrane but also must pass through the dense matrix of the cell wall. The greatest unknown in the area of fungal vesicles is the mechanism by which these vesicles are released to the extracellular space given the presence of the fungal cell wall. Here we used electron microscopy techniques to image the interactions of vesicles with the cell wall. Our goal was to define the ultrastructural morphology of the process to gain insights into the mechanisms involved. We describe single and multiple vesicle-leaving events, which we hypothesized were due to plasma membrane and multivesicular body vesicle origins, respectively. We further utilized melanized cells to "trap" vesicles and visualize those passing through the cell wall. Vesicle size differed depending on whether vesicles left the cytoplasm in single versus multiple release events. Furthermore, we analyzed different vesicle populations for vesicle dimensions and protein composition. Proteomic analysis tripled the number of proteins known to be associated with vesicles. Despite separation of vesicles into batches differing in size, we did not identify major differences in protein composition. In summary, our results indicate that vesicles are generated by more than one mechanism, that vesicles exit the cell by traversing the cell wall, and that vesicle populations exist as a continuum with regard to size and protein composition.
Quadruply Fused Aromatic Heterocycles toward 4 V‐Class Robust Organic Cathode‐Active Materials (2022)

Abstract Quadruply fused aromatic heterocycles are examined as 4 V‐class organic cathode‐active materials. A newly synthesized dimethylfluoflavin‐substituted polymer displays reversible charge/discharge at high potentials of 3.5 and 4.1 V (vs. Li/Li + ) as a cathode‐active material for organic secondary batteries. The robust redox‐active heterocycles enable the long cycle‐life (&gt;1000) while maintaining the high potential over 4 V. The linear polymer backbone and radical spin configuration in the heterocycles are the keys to enhancing the voltages and the cycle life.