gebhart/patrepeval huggingface dataset:
Diagnosis and Remediation of Single-Turn Short Circuit in a Multiphase FSCW PM Machine Based on T-type Equivalent Circuit (2019)

Single-turn short circuit (STSC) refers to the most severe turn fault condition in which the number of shorted turns is only one. Since winding inductance is proportional to the square of number of turns, STSC suffers from significantly large circulating current inside the faulted turn. The objective of this article is to provide practical approaches that enable fault detection and postfault operation. A previously developed T-type equivalent circuit laid a solid foundation for the proposed methods. High-frequency injection and signal processing method are carried out for reliable online fault diagnosis, while postfault operation is based on shorting the remaining turns as well as instantaneous power balance theory. Experimental results confirm the effectiveness of the proposed methods.
Measurement of the t-channel single top-quark production cross section in pp collisions at √s = 7 TeV with the ATLAS detector (2012)

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAM
An Insecticidal and Acaricidal Polysulfide Metabolite from the Roots ofPetiveria alliacea (1997)

The present study reports on the insecticidal and acaricidal potentials of dibenzyltrisulfide (DBTS) isolated from the roots of Petiveria alliacea L. using thin layer and high performance liquid chromatography. The 96-h LD50 value (μg per tick) obtained for adult Boophilus microplus (Canestrini) topically treated with DBTS was 0·920. The LD50 values obtained for three commercial acaricides dimethoate, lindane and carbaryl were 4·6, 9·3 and 6·9 μg per tick respectively. The IOD50 and IHD50 (concentrations inhibiting egg laying and hatching by 50% respectively) in μg per tick doses for DBTS were 0·22 and 0·24 respectively. The 24-h LD50 dose (μg per insect) obtained for DBTS on adult Cylas formicarius elegantulus (Summer) was 0·193 μg per insect. The vapour from a stock solution of 5 g litre-1 of DBTS was highly toxic to adult Hypothenemus hampei Ferr. inside coffee berries, inflicting 89% mortality within 24 h. © 1997 SCI.
The functional role of acute phase plasma proteinase inhibitors. (1988)

Human plasma contains an array of proteinase inhibitors which are utilized in the regulation of a host of biological activities, including coagulation, fibrinolysis, connective tissue turnover, and complement activation. The concentration of several of these inhibitors increase at varying rates in the acute phase state while others remain constant or actually decrease. Increases are presumably an attempt to retain rigid control over certain critical reactions, while decreases are probably due to inhibitor turnover either through consumption during complex formation or inactivation by other endogenous proteinases. Virtually all of these latter reactions take place in a reactive site loop which is an exposed region present in at least eight related serine proteinase inhibitors (Serpins) in plasma. Complex formation and inhibitor inactivation presumably act as signals for inhibitor production and turnover in the acute phase state. However, exactly how this initial stimulus for increased protein synthesis is manifested at the protein level remains to be established.
The Association Between Socioeconomic Status and Overweight/Obesity in a Malay Population in Singapore (2009)

In developed countries in the West, lower socioeconomic status (SES) is associated with a higher prevalence of overweight/obesity. The authors examined the association between SES defined by education and income and overweight/obesity in a population-based cohort of 2807 individuals of Malay ethnicity (age 40-80 years, 51% women) in Singapore. The prevalence of overweight/ obesity (body mass index > or =25 kg/m(2)) in men and women was 50.4% and 65.1%, respectively. In women, the prevalence of overweight/obesity increased with lower levels of education and income. Compared with the higher categories of SES, the odds ratio (95% confidence interval) of overweight/obesity in women was 1.42 (1.06-1.89) for education and 2.08 (1.33-3.26) for income. In contrast, in men, the prevalence of overweight/obesity decreased with lower levels of education and income (P interaction by gender <.05 for all SES variables). Lower SES was positively associated with overweight/obesity in Malay women, and the association was in the opposite direction in Malay men.
Interactions between Retroviruses and the Host Cell Genome (2017)

Replication-defective retroviral vectors have been used for more than 25 years as a tool for efficient and stable insertion of therapeutic transgenes in human cells. Patients suffering from severe genetic diseases have been successfully treated by transplantation of autologous hematopoietic stem-progenitor cells (HSPCs) transduced with retroviral vectors, and the first of this class of therapies, Strimvelis, has recently received market authorization in Europe. Some clinical trials, however, resulted in severe adverse events caused by vector-induced proto-oncogene activation, which showed that retroviral vectors may retain a genotoxic potential associated to proviral integration in the human genome. The adverse events sparked a renewed interest in the biology of retroviruses, which led in a few years to a remarkable understanding of the molecular mechanisms underlying retroviral integration site selection within mammalian genomes. This review summarizes the current knowledge on retrovirus-host interactions at the genomic level, and the peculiar mechanisms by which different retroviruses, and their related gene transfer vectors, integrate in, and interact with, the human genome. This knowledge provides the basis for the development of safer and more efficacious retroviral vectors for human gene therapy.
Cholangiocyte‐specific rat liver proteins identified by establishment of a two‐dimensional gel protein database (1998)

The liver is composed of a variety of cells that form a functional unit involved in uptake, synthesis, metabolism, and secretion. Until recently, most studies examining liver function did not analyze the specific proteins expressed or functions performed by the multiple individual cell types that constitute the hepatic mass. In the last decade, novel isolation methods have been developed that allow the purification of liver cell populations highly enriched in one type of liver cell. Here, we present a detailed two-dimensional (2-D) protein map of rat bile duct epithelial cells (i.e., cholangiocytes) using a recently developed isolation procedure. In addition, we identify 27 major cholangiocyte proteins either by comparison to maps of known rat liver proteins (based on pI and Mr) or by tryptic digestion and microsequencing. Finally, we compare the relative abundance of individual proteins present in cholangiocytes to whole liver as well as hepatocyte-specific proteins. Our results show that cholangiocytes express a unique array of individual proteins. The cholangiocyte 2-D protein pattern is markedly different from that of isolated rat hepatocytes or whole rat liver, with high levels of proteins previously known to be expressed by cholangiocytes (e.g., cytokeratins, actins) as well as protein not previously demonstrated to be expressed at high levels (e.g., annexin V, selenium binding protein). We conclude that this cholangiocyte-derived, 2-D protein map will be a crucial resource for studies directed at our understanding of cholangiocyte physiology and pathobiology.
Infrared and resonance Raman spectroscopic studies of 1‐hydroxy‐9,10‐anthraquinone and its metal complexes (1987)

Abstract Infrared and resonance Raman spectra of 1‐hydroxy‐9, 10‐anthraquinone, its deuteriated and deprotonated forms and its metal chelates with Cu II , Ni II and Co II ions are presented. Vibrational assignments of the carbonyl, hydroxyl and the chelating unit of this chromophore are emphasized. It is found that the different metal ions force delocalization of the electrons on the chelate rings to different extents. The intensities of the Raman bands under resonance conditions suggest that the electronic band in the visible region is mainly of a charge‐transfer type from the metal to the ligand.
FEIBA®: mode of action (2004)

FEIBA (factor eight inhibitor bypassing activity) has a history of more than 30 years of successful use in controlling bleeding in haemophilic patients who have developed inhibitory antibodies against factor (F)VIII or FIX. Recently it was shown that FEIBA contains the proenzymes of the prothrombin complex factors, prothrombin, FVII, FIX and FX, but only very small amounts of their activation products, with the exception of FVIIa, which is contained in FEIBA in greater amounts. FEIBA controls bleeding by induction and facilitation of thrombin generation, a process for which FV is crucial. A number of biochemical in vitro and in vivo studies have shown that FXa and prothrombin play a critical role in the activity of FEIBA. Consequently, they are considered to be key components of this product. The prothrombinase complex has been found to be a major target site for FEIBA. Apart from prothrombin and FXa, FEIBA contains other proteins of the prothrombin complex, which could also facilitate haemostasis in haemophilia patients with inhibitors.
The Year 2022 in biomaterials research: A perspective from the editors of six leading journals (2023)

The field of biomaterials science is highly active, with a steadily increasing number of publications and new journals being founded. This article brings together contributions from the editors of six leading journals in the area of biomaterials science and engineering. Each contributor highlights specific advances, topics, and trends that have emerged through the publications in their respective journal in the calendar year 2022. It presents a global perspective on a wide range of material types, functionalities, and applications. The highlighted topics include a diversity of biomaterials; from proteins, polysaccharides, and lipids to ceramics, metals, advanced composites, and a variety of new forms of these materials. Important advances in dynamically functional materials are presented, including a range of fabrication techniques such as bioassembly, 3D bioprinting and microgel formation. Similarly, several applications are highlighted in drug and gene delivery, biological sensing, cell guidance, immunoengineering, electroconductivity, wound healing, infection resistance, tissue engineering, and treatment of cancer. The goal of this paper is to provide the reader with both a broad view of recent biomaterials research, as well as expert commentary on some of the key advances that will shape the future of biomaterials science and engineering.
Evaluation of variants in the selectin genes in age-related macular degeneration (2011)

This genetic screen did not detect any SNPs that were highly associated with AMD affection status overall. However, subtype analysis showed that a single SNP located within an intron of SELP (rs3917751) is statistically associated with dry AMD in our cohort. Future studies with additional cohorts and functional assays will clarify the biological significance of this discovery. Based on our findings, it is unlikely that common ancestral variants in the other selectin genes (SELE and SELL) are risk factors for AMD. Finally, it remains possible that sporadic or rare mutations in SELE, SELL, or SELP have a role in the pathogenesis of AMD.
Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor (2017)

The ongoing epidemics of opioid overdose raises an urgent need for effective antiaddiction therapies and addiction-free painkillers. The κ-opioid receptor (KOR) has emerged as a promising target for both indications, raising demand for new chemotypes of KOR antagonists as well as G-protein-biased agonists. We employed the crystal structure of the KOR-JDTic complex and ligand-optimized structural templates to perform virtual screening of available compound libraries for new KOR ligands. The prospective virtual screening campaign yielded a high 32% hit rate, identifying novel fragment-like and lead-like chemotypes of KOR ligands. A round of optimization resulted in 11 new submicromolar KOR binders (best K<sub>i</sub> = 90 nM). Functional assessment confirmed at least two compounds as potent KOR antagonists, while compound 81 was identified as a potent G<sub>i</sub> biased agonist for KOR with minimal β-arrestin recruitment. These results support virtual screening as an effective tool for discovery of new lead chemotypes with therapeutically relevant functional profiles.
In-plane comb-drive actuator with high frequency-displacement product for micro-optical bench applications (2014)

This work reports the design, implementation and testing of an in-plane comb-drive actuator achieving a travel range of 17.8 μm at a resonance frequency of 26 kHz, and monolithically integrated with a vertical micromirror. The product of the travel range and the frequency is 463 μm.kHz, indicating the maximum linear velocity of the micromirror, is the highest of a MEMS in-plane actuator reported under atmospheric pressure, to the best of the authors' knowledge. The design is fabricated using the DRIE technology on an SOI wafer and tested optically by counting the interferometric fringes formed between the micromirror surface and a standard single-mode fiber at the wavelength of 1550 nm.
Supplementary Methods from The MD Anderson Prostate Cancer Patient-derived Xenograft Series (MDA PCa PDX) Captures the Molecular Landscape of Prostate Cancer and Facilitates Marker-driven Therapy Development (2023)

&lt;p&gt;Supplementary Methods&lt;/p&gt;
Novel inhibitor candidates of TRPV2 prevent damage of dystrophic myocytes and ameliorate against dilated cardiomyopathy in a hamster model (2018)

Transient receptor potential cation channel, subfamily V, member 2 (TRPV2) is a principal candidate for abnormal Ca<sup>2+</sup>-entry pathways, which is a potential target for therapy of muscular dystrophy and cardiomyopathy. Here, an <i>in silico</i> drug screening and the following cell-based screening to measure the TRPV2 activation were carried out in HEK293 cells expressing TRPV2 using lead compounds (tranilast or SKF96365) and off-patent drug stocks. We identified 4 chemical compounds containing amino-benzoyl groups and 1 compound (lumin) containing an ethylquinolinium group as candidate TRPV2 inhibitors. Three of these compounds inhibited Ca<sup>2+</sup> entry through both mouse and human TRPV2, with IC<sub>50</sub> of less than 10 μM, but had no apparent effect on other members of TRP family such as TRPV1 and TRPC1. Particularly, lumin inhibited agonist-induced TRPV2 channel activity at a low dose. These compounds inhibited abnormally increased Ca<sup>2+</sup> influx and prevented stretch-induced skeletal muscle damage in cultured myocytes from dystrophic hamsters (J2N-k). Further, they ameliorated cardiac dysfunction, and prevented disease progression <i>in vivo</i> in the same J2N-k hamsters developing dilated cardiomyopathy as well as muscular dystrophy. The identified compounds described here are available as experimental tools and represent potential treatments for patients with cardiomyopathy and muscular dystrophy.
Validation of a Multivariate Serum Profile for Epithelial Ovarian Cancer Using a Prospective Multi-Site Collection (2010)

Abstract In previous studies we described the use of a retrospective collection of ovarian cancer and benign disease samples, in combination with a large set of multiplexed immunoassays and a multivariate pattern recognition algorithm, to develop an 11-biomarker classification profile that is predictive for the presence of epithelial ovarian cancer. In this study, customized, Luminex-based multiplexed immunoassay kits were GMP-manufactured and the classification profile was refined from 11 to 8 biomarkers (CA-125, epidermal growth factor receptor, CA 19-9, C-reactive protein, tenascin C, apolipoprotein AI, apolipoprotein CIII, and myoglobin). The customized kits and the 8-biomarker profile were then validated in a double-blinded manner using prospective samples collected from women scheduled for surgery, with a gynecologic oncologist, for suspicion of having ovarian cancer. The performance observed in model development held in validation, demonstrating 81.1% sensitivity (95% CI 72.6 – 87.9%) for invasive epithelial ovarian cancer and 85.4% specificity (95% CI 81.1 – 88.9%) for benign ovarian conditions. The specificity for normal healthy women was 95.6% (95% CI 83.6 – 99.2%). These results have encouraged us to undertake a second validation study arm, currently in progress, to examine the performance of the 8-biomarker profile on the population of women not under the surgical care of a gynecologic oncologist.
Improving transport design for WARP SDR deployments (2014)

Software-Defined radios (SDRs) are a popular platform for developing and implementing wireless protocols. Their basic architecture consists of radio front-ends hosted on an FGPA board, and a back-end processing host for running bulk of the signal processing in software. The two components are bridged, usually by an Ethernet or PCIe interface that transports the radio samples. In addition to the processing delay in software, SDRs may experience a non-negligible transport latency, for example, due to the limited Ethernet bandwidth.
Guest Editorial Special Issue on 3D-TV Horizon: Contents, Systems, and Visual Perception (2011)

Despite initial skepticism, there is a growing consensus that the broadcast industry needs to seriously consider the pros and cons of providing services for three-dimensional television (3D-TV). In addition to the two-dimensional visual cues of perspective, size, shading, texture, blur, etc., that are offered by standard television images, 3D-TV will provide stereoscopic depth information in the form of disparity signals from paired images for both stereoscopic and multiview autostereoscopic display systems.
Studying Potential Side Channel Leakages on an Embedded Biometric Comparison System. (2014)

We study in this work the potential side channel leakages of a hardware biometric comparison system that has been designed for fingerprints. An embedded biometric system for comparison aims at comparing a stored biometric data with a freshly acquired one without the need to send the stored biometric data outside the system. Here one may try to retrieve the stored data via side channel, similarly as for embedded cryptographic modules where one may try to exploit side channel for attacking the modules. On one hand, we show that we can find partial information by the means of simple Side Channel Analysis that may help to retrieve the stored fingerprint. On the other hand, we illustrate that reconstructing the fingerprint remains not trivial and we give some simple countermeasures to protect further the comparison algorithm.
High-Throughput Purification Platform in Support of Drug Discovery (2011)

The application of parallel synthesis is an efficient approach to explore the chemical space and to rapidly develop meaningful structure activity relationship (SAR) data for drug discovery programs. However, the effectiveness of the parallel synthesis requires a high throughput purification workflow that can process a large number of crude samples within a meaningful time frame. This paper describes a high throughput purification platform that has been adopted at Merck's Rahway research site. The platform includes the evaluation of crude samples, mass-directed HPLC purification, fraction analysis, compound registration, final compound purity assessment and assay distribution. Assisting with the sample tracking and the data management is the internally designed laboratory information management system, Light Automation Framework (LAF). Using this process and the tools described herein, the group has successfully achieved purities of 95% or greater for 90% of samples.
Effective field and universal mobility in high-k metal gate UTBB-FDSOI devices (2014)

This paper aims at reviewing experimental and theoretical behaviors of universal mobility in high-k metal gate UTBB-FDSOI devices. Based on split-CV mobility measurements, the parameter η characterizing the effective field, has been extracted for a large range of back voltages and temperatures in devices with various equivalent oxide thicknesses. We demonstrated that a nearly universal trend for the mobility with respect to the effective field can be obtained in the front inversion regime but is difficult to obtain in the back channel inversion regime.
Electro-Catalytic Activity of RuO<SUB>2</SUB>–IrO<SUB>2</SUB>–Ta<SUB>2</SUB>O<SUB>5</SUB> Mixed Metal Oxide Prepared by Spray Thermal Decomposition for Alkaline Water Electrolysis (2016)

Oxygen evolution reaction for alkaline water electrolysis was studied using various mixed metal oxide catalysts. Mixed metal oxide electrodes consisting of RuO2, IrO2, and Ta2O5 with various ratios on a titanium substrate were prepared by spray thermal decomposition. The crystallinity of the synthesized catalyst was investigated via X-ray diffraction, and the oxidation state of each component was determined using X-ray photoelectron spectroscopy (XPS). Surface morphology was investigated by scanning electron microscopy, and the roughness factor was determined by cyclic voltammetry (CV) in 1 M H2SO4. Electo-catalytic activity for oxygen evolution reaction was measured by cyclic voltammetry (CV) in 1 M KOH at room temperature, and it was found to be strongly dependent.on composition of catalyst. Among all electrodes tested, catalyst with a composition of Ru:Ir:Ta = 1:2:2.5 exhibited the highest current density of 100 mA cm(-2) at 1.67 V, corresponding to an overpotential of 0.44 V.