gebhart/patrepeval huggingface dataset:
Coastal Atlas Interoperability (2010)

This chapter defines the coastal web atlases interoperability problem, introduces interoperability standards, and describes the development of a semantic mediator prototype to provide a common access point to coastal data, maps and information from distributed coastal web atlases. The prototype showcases how ontologies and ontology mappings can be used to integrate different heterogeneous and autonomous atlases (or information systems), using international standards such as ISO-19139 for metadata encoding and the Open Geospatial Consortium’s Catalogue Service for the Web specification. Lessons learned from this prototype will help build regional atlases and improve decision support systems as part of a new International Coastal Atlas Network (ICAN).
Impact of Channel State Misreporting on Multi-user Massive MIMO Scheduling Performance (2018)

The robustness of system throughput with scheduling is a critical issue. In this paper, we analyze the sensitivity of multi-user scheduling performance to channel misreporting in systems with massive antennas. The main result is that for the round-robin scheduler combined with max-min power control, the channel magnitude misreporting is harmful to the scheduling performance and has a different impact from the purely physical layer analysis. Specifically, for the homogeneous users that have equal average signal-to-noise ratios (SNRs), underreporting is harmful, while overreporting is beneficial to others. In underreporting, the asymptotic rate loss on others is derived, which is tight when the number of antennas is huge. One interesting observation in our research is that the rate loss "periodically" increases and decreases as the number of misreporters grows. For the heterogeneous users that have various SNRs, both underreporting and overreporting can degrade the scheduler performance. We observe that strong misreporting changes the user grouping decision and hence greatly decreases some users' rates regardless of others gaining rate improvements, while with carefully designed weak misreporting, the scheduling decision keeps fixed and the rate loss on others is shown to grow nearly linearly with the number of misreporters.
Design, fabrication, and characterization of a scalable tissue-engineered-electronic-nerve-interface (TEENI) device (2017)

In this study, we describe a novel peripheral-nerve interface which makes use of highly flexible multi-electrode arrays that are integrated into hydrogel-based scaffolds to form a hybrid tissue-engineered electronic construct. This tissue-engineered electronic nerve interface (TEENI) is designed to be scalable to high channel counts using multiple polyimide-based “threads” that are evenly distributed through a volume of the nerve equal to its diameter times the distance between one or more nodes of Ranvier. Such scalability could greatly increase the precision and resolution of motor-control and sensory-feedback signals exchanged between amputees and advanced upper-limb prosthetic devices.
Lack of a 5' non-coding region in Tn1721encodedtetRmRNA is associated with a low efficiency of translation and a short half-life inEscherichia coil (1991)

The repressor-encoding tetR gene from Tn1721 is expressed with a very low efficiency. Its mRNA lacks an untranslated leader sequence. We have constructed protein fusions with the lacZ gene which contain between 14 and 157 5' nucleotides from the tetR gene. Since they are all expressed with similar efficiencies we conclude that the sequence information for initiation of translation is contained within the first 14 bases of the tetR coding region. These fusion transcripts are about 20-fold less efficiently translated than the wild type lacZ transcript. A toeprint analysis confirms that the initiation complex is indistinguishable from those formed by regular transcripts with 5' untranslated regions but occurs in a very low amount in vitro. Thus, the absence of a 5' leader causes a poor rate of translation initiation. The half-lives of tetR and tetR-lacZ mRNAs are about 30 seconds, which is 3-times lower than that of the wt lacZ mRNA. Inactivation of the ams/rne locus in E. coli stabilizes the tetR transcript more than ten-fold. The influence of translation on the tetR half-life is discussed.
Vertical Si-Metal-Oxide-Semiconductor Field Effect Transistors with Channel Lengths of 50 nm by Molecular Beam Epitaxy (1994)

The growth conditions in molecular beam epitaxy (MBE) were studied for the fabrication of vertical Si-metal-oxide-semiconductor field effect transistors (MOSFET) with channel lengths down to 50 nm. The short channel length imposes severe constraints on the doping profile. MBE growth provided a steepness of 10 nm/dec for boron and 2 nm/dec for antimony. The sharpness of the doping profile was sustained throughout the process by keeping all process temperatures below 700° C. The high crystal quality and the well-defined doping profile was verified by the good performance of a triangular barrier diode. A vertical n-MOSFET with an estimated channel length of 50 nm was grown. The drain and gate characteristics were discussed for a source drain voltage regime from U sd =0 V to 1 V.
Structural densification of lithium phosphoaluminoborate glasses (2020)

Abstract Lithium aluminoborate glasses have recently been found to undergo dramatic changes in their short‐range structures upon compression at moderate pressure (~1 GPa), most notably manifested in an increase in network forming cation coordination number (CN). This has important consequences for their mechanical behavior, and to further understand the structural densification mechanisms of this glass family, we here study the effect of P 2 O 5 incorporation in a lithium aluminoborate glass (with fixed Li/Al/B ratio) on the pressure‐induced changes in structure, density, and hardness. We find that P 2 O 5 addition results in a more open and soft network, with P‐O‐Al and P‐O‐B bonding, a slightly smaller fraction of tetrahedral‐to‐trigonal boron, and an unchanged aluminum speciation. Upon compression, the cation‐oxygen CNs of both boron and aluminum increase systemically, whereas the number of bridging oxygens around phosphorous ( Q n ) decreases. The glasses with higher P 2 O 5 content feature a larger decrease in Q n (P) upon compression, which leads to more non‐bridging oxygen that in turn fuel the larger increase in CN of B and Al for higher P 2 O 5 content. We find that the CN changes of Al and B can account for a large fraction (around 50% at 2 GPa) of the total volume densification and that the extent of structural changes (so‐called atomic self‐adaptivity) scales well with the extent of volume densification and pressure‐induced increase in hardness.
Sparsity based depth estimation and hole-filling algorithm for 2D to 3D video conversion (2012)

Depth image-based rendering (DIBR) requires to efficiently fill out holes in rendered image, and this has a great impact on the quality of 3D depth perception. In this paper, we propose a hole-filling method using depth estimation and image inpainting for high quality 3D video. In this algorithm, we first generate rendered image and its associated depth map. Then, we estimate the depths in generated depth map's hole. Using these values, we fill out the hole with depth-aided image inpainting based on the sparsity of hole. This method enables the inpainting to refer similar background texture. The proposed algorithm also fills out the patches of hole based on an edge-preserving priority, so that background edges of the image texture can be reconstructed faithfully. Experimental results show that the proposed algorithm provides better objective and subjective quality than previous works.
Distance-adaptive super-wavelength routing in elastic optical path network (SLICE) with optical OFDM (2010)

We propose a spectrally-efficient super-wavelength-path routing in SLICE by selecting a set of subcarrier numbers and modulation levels according to path distances. We demonstrate 420 Gb/s path routing using short-reach 14-subcarrier 8-APSK and long-reach 21-subcarrier QPSK.
Ultra-low voltage triggered release of an anti-cancer drug from polypyrrole nanoparticles (2018)

We have synthesized polypyrrole nanoparticles using three different oxidizing agents (hydrogen peroxide, chloroauric acid and ferric chloride) and shown that films assembled from these nanoparticles have significantly different drug release profiles. When ferric chloride is used as the oxidizing agent, it is possible to release drugs at voltages as low as -0.05 V, almost an order of magnitude lower than typically used voltages. These ultra-low voltage responsive nanoparticles widen the window of operation of conducting polymers and enable delivery of redox active drugs. As an example, we have shown pulsed release of the chemotherapeutic methotrexate at voltages as low as -0.075 V, demonstrating the potential application of these nanoparticles in cancer treatment. We have also verified the anti-tumor efficacy of the released drug using PC12 cell cultures.
HIV and Aging (2012)

HIV risk behaviors, susceptibility to HIV acquisition, progression of disease after infection, and response to antiretroviral therapy all vary by age. In those living with HIV, current effective treatment has increased the median life expectancy to >70 years of age. Biologic, medical, individual, social, and societal issues change as one ages with HIV infection, but there has been only a small amount of research in this field. Therefore, the Office of AIDS Research of the National Institutes of Health commissioned a working group to develop an outline of the current state of knowledge and areas of critical need for research in HIV and Aging; the working groups' findings and recommendations are summarized in this report. Key overarching themes identified by the group included the following: multimorbidity, polypharmacy, and the need to emphasize maintenance of function; the complexity of assessing HIV versus treatment effects versus aging versus concurrent disease; the inter-related mechanisms of immune senescence, inflammation, and hypercoagulability; the utility of multivariable indices for predicting outcomes; a need to emphasize human studies to account for complexity; and a required focus on issues of community support, caregivers, and systems infrastructure. Critical resources are needed to enact this research agenda and include expanded review panel expertise in aging, functional measures, and multimorbidity, and facilitated use and continued funding to allow long-term follow-up of cohorts aging with HIV.
Gas chromatography/mass spectrometry in aroma chemistry: a comparison of essential oils and flavours extracted by classical and supercritical techniques (1997)

Gas chromatography/mass spectrometry has been used as an analytical method for the determination of the composition of the essential oils of lavender, basil, clove and ginger extracted by means of a supercritical fluid extraction plant. These data, compared with those obtained analysing the same essential oils extracted by means of more classical techniques, i.e. steam distillation and liquid extraction, prove the effectiveness of supercritical fluid extraction in aroma chemistry. © 1997 John Wiley & Sons, Ltd.
Mechanism of the Water–Gas Shift Reaction Catalyzed by Efficient Ruthenium‐Based Catalysts: A Computational and Experimental Study (2018)

Supported ionic liquid phase (SILP) catalysis enables a highly efficient, Ru-based, homogeneously catalyzed water-gas shift reaction (WGSR) between 100 °C and 150 °C. The active Ru-complexes have been found to exist in imidazolium chloride melts under operating conditions in a dynamic equilibrium, which is dominated by the [Ru(CO)<sub>3</sub> Cl<sub>3</sub> ]<sup>-</sup> complex. Herein we present state-of-the-art theoretical calculations to elucidate the reaction mechanism in more detail. We show that the mechanism includes the intermediate formation and degradation of hydrogen chloride, which effectively reduces the high barrier for the formation of the requisite dihydrogen complex. The hypothesis that the rate-limiting step involves water is supported by using D<sub>2</sub> O in continuous catalytic WGSR experiments. The resulting mechanism constitutes a highly competitive alternative to earlier reported generic routes involving nucleophilic addition of hydroxide in the gas phase and in solution.
PC-Based Tele-Audiometry (2007)

A personal computer (PC)-based audiometer was developed for interactive remote audiometry. This paper describes a tele-audiometric system and evaluates the performance of the device when compared with conventional face-to-face audiometry. The tele-audiometric system is fully PC-based. A sound card featuring a high-quality digital-to-analog converter is used as a pure-tone generator. The audiometric programs were developed based on Microsoft Windows in order to maximize usability. Audiologists and their subjects can use the tele-audiometry system as one would utilize any PC application. A calibration procedure has been applied for the standardization of sound levels in the remote system. The performance of this system was evaluated by comparing PC-based audiometry with the conventional clinical audiometry system for 37 subjects. Also, performance of the PC-based system was evaluated during use at a remote site. The PC-based audiometry system estimated the audiometric threshold with an error of less than 2.3 dBSPL. Only 10.7% of the results exhibited an error greater than 5 dBSPL during use at a remote site. The PC-based tele-audiomerty showed acceptable results for use at a remote site. This PC-based system can be used effectively and easily in many locations that have Internet access but no local audiologists.
Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy (2017)

The efficacy of antiretroviral therapy is significantly compromised by medication non-adherence. Long-acting enteral systems that can ease the burden of daily adherence have not yet been developed. Here we describe an oral dosage form composed of distinct drug-polymer matrices which achieved week-long systemic drug levels of the antiretrovirals dolutegravir, rilpivirine and cabotegravir in a pig. Simulations of viral dynamics and patient adherence patterns indicate that such systems would significantly reduce therapeutic failures and epidemiological modelling suggests that using such an intervention prophylactically could avert hundreds of thousands of new HIV cases. In sum, weekly administration of long-acting antiretrovirals via a novel oral dosage form is a promising intervention to help control the HIV epidemic worldwide.
Influence of high-pressure torsion on formation/destruction of nano-sized spinodal structures (2018)

The microstructures and hardness of Al - 30 mol.% Zn are investigated after processing by high-pressure torsion (HPT) for different numbers of revolutions, N = 1, 3, 10 or 25, as well as after post-HPT annealing at different temperatures, T = 373 K, 473 K, 573 K and 673 K. It was found that a work softening occurs by decreasing the grain size to the submicrometer level and increasing the fraction of high-angle boundaries. As a result of HPT processing, a complete decomposition of supersaturated solid solution of Zn in Al occurs and the spinodal structure is destroyed. This suggests that softening of the Al-Zn alloys after HPT is due to the decomposition of the supersaturated solid solution and destruction of spinodal decomposition. After post-HPT annealing, ultrafine-grained Al-Zn alloys show an unusual mechanical properties and its hardness increased to 187 HV. Microstructural analysis showed that the high hardness after post-HPT annealing is due to the formation of spinodal structures.
Organophosphate Poisining in Office Workers (1986)

Five occupants of an office developed symptoms compatible with organophosphate intoxication after application of chlorpyrifos, a moderately toxic pesticide. Recovery of erythrocyte cholinesterase levels occurred during the subsequent three months but followed an exponential distribution rather than the constant rate of recovery most investigators have assumed. This pattern suggests redistribution of the active organophosphate after absorption to a second body compartment with subsequent slow release of the still active substance into the bloodstream.
TIGA: Target illumination GWAS analytics (2020)

Abstract Genome wide association studies (GWAS) can reveal important genotype–phenotype associations, however, data quality and interpretability issues must be addressed. For drug discovery scientists seeking to prioritize targets based on the available evidence, these issues go beyond the single study. Here, we describe rational ranking, filtering and interpretation of inferred gene–trait associations and data aggregation across studies by leveraging existing curation and harmonization efforts. Each gene–trait association is evaluated for confidence, with scores derived solely from aggregated statistics, linking a protein-coding gene and phenotype. We propose a method for assessing confidence in gene–trait associations from evidence aggregated across studies, including a bibliometric assessment of scientific consensus based on the iCite Relative Citation Ratio, and meanRank scores, to aggregate multivariate evidence. This method, intended for drug target hypothesis generation, scoring and ranking, has been implemented as an analytical pipeline, available as open source, with public datasets of results, and a web application designed for usability by drug discovery scientists, at https://unmtid-shinyapps.net/tiga/ .
Properties of Charge Carrier Transport in Au/Phenyl C61 Butyric Acid Methyl Ester/Au Structure (2011)

The properties of charge carrier transport through the Au/phenyl C 61 butyric acid methyl ester/Au (Au/PCBM/Au) structure are studied by measuring DC currents passing through the structure at various temperatures and in the presence of an external electric field. Temperature- and field-strength dependent conductivities show that the energy band gap of the PCBM crystalline solid is 1.70 eV, and this value depends on the pressure during its preparation. There is a thermally activated process that controls the carrier mobility of this PCBM solid. We found out that its activation energy is influenced by the external electric field, and it increases with increasing field strength. The activation energy increases from 2 to 110 meV corresponding to a variation of the field strength from 50 to 1000 V cm -1 . Theoretical calculation shows that the magnitude of the potential barrier for carrier transport through the structure increases only from 2 to 7 meV in the same field strength range owing to the Schottky effect on the Au/PCBM interface. Therefore, the field-strength-dependent mobility plays a more important role than the Schottky effect on the carrier transport through the structure.
Influence of Bioreceptor Layer Structure on Myelin Basic Protein Detection using Organic Field Effect Transistor‐Based Biosensors (2018)

Abstract Organic field‐effect transistor (OFET)‐based biosensors with antibody receptors are widely considered for protein antigen detection. To the authors' knowledge, there are no comparative evaluations to date of different choices for the matrix polymer to which the antibodies are attached. Herein, multiple acrylic copolymers are studied as receptor layers with myelin basic protein and its corresponding antibody as an archetypal antibody–antigen pair. Stability against multiple washing steps and the capacity for immobilizing antibodies on polymers on device surfaces with the help of fluorescein isothiocyanate‐labeled antibodies are compared. Electronic detection and selectivity are also observed. The conclusions provide guidance on the selection of bioreceptor material for increasing sensitivity and process stability of OFET biosensors.
Novel Millimeter-wave Electro-optic Modulator (2005)

A waveguide LiNbO_3 electro-optic modulator has been demonstrated with a novel wave-coupling technique which greatly reduces phase-velocity mismatch. An 8-12 GHz version produces 48° phase modulation with 126 mW of drive power. A 60 GHz version is being built.
Optimized method for measuring cyclosporin A with /sup 125/I-labeled cyclosporin (1986)

We evaluated the use of the new iodinated ligand for the in vitro measurement of cyclosporin A by radioimmunoassay (RIA). Substitution of the iodinated cyclosporin (/sup 125/I-CyA) for the corresponding tritium-labeled analog (/sup 3/H-CyA) considerably simplifies and accelerates the currently available RIA, and improves its precision. Analysis of the respective dose-response curves showed that the 50% B0 value was lower for the /sup 125/I-CyA assay than for the /sup 3/H-CyA assay (37 vs 77 micrograms/L). Use of whole-blood specimens minimized interferences from temperature and hematocrit. We conclude that the use of /sup 125/I-CyA in a commercially available RIA for whole-blood specimens is accessible to most laboratories and provides rapid, reproducible data for management of transplant patients.
Photoinduced Synthesis of Diorganozinc and Organozinc Iodide Reagents (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTPhotoinduced Synthesis of Diorganozinc and Organozinc Iodide ReagentsAndré B. Charette, André Beauchemin, and Jean-François MarcouxView Author Information Département de Chimie, Université de Montréal Québec, Canada H3C 3J7 Cite this: J. Am. Chem. Soc. 1998, 120, 20, 5114–5115Publication Date (Web):May 6, 1998Publication History Received28 January 1998Published online6 May 1998Published inissue 1 May 1998https://pubs.acs.org/doi/10.1021/ja980318fhttps://doi.org/10.1021/ja980318frapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views1199Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alkyls,Anions,Chemical reactions,Irradiation,Reagents Get e-Alerts