gebhart/patrepeval huggingface dataset:
Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2 (1994)

<h3>Objective.</h3> —To determine the efficacy of treatment using high-dose bolus Interleukin 2 (IL-2) in patients with metastatic melanoma or renal cell cancer. <h3>Design and Setting.</h3> —Consecutive series of all patients treated with high-dose IL-2 in the Surgery Branch of the National Cancer Institute from September 1985 through December 1992. <h3>Patients.</h3> —Two hundred eighty-three patients with metastatic melanoma or metastatic renal cell cancer who had failed standard treatment for their cancers. <h3>Interventions.</h3> —Patients received IL-2 at a dose of 720 000 lU/kg intravenously every 8 hours for a maximum of 15 doses per cycle. Two cycles constituted a treatment course, and patients with stable or responding disease received additional treatment courses. A total of 447 courses of treatment were administered. <h3>Main Outcome Measures.</h3> —Regression of measurable tumor, durability of response to treatment, and survival. <h3>Results.</h3> —Nine patients (7%) with metastatic melanoma achieved complete regression of all disease and 14 patients (10%) had partial regression. Ten patients (7%) with metastatic renal cell cancer experienced complete regression and 20 patients (13%) had partial regression. Of the 19 patients with complete regression, 15 have remained in complete remission from 7 to 91 months after treatment. Three treatment-related deaths (1.1%) occurred early in this series, but as experience with the administration of this IL-2 regimen increased, no treatment-related deaths occurred in 214 patients treated during the last 5 years of the study. <h3>Conclusion.</h3> —Biologic therapy with IL-2 can cause significant antitumor effects in patients with advanced metastatic melanoma or renal cell cancer. Because IL-2 does not have a direct effect on cancer cells but rather mediates its antitumor activity by altering host immune reactions, these data represent the best available evidence that immunologic therapy for cancer can be effective in selected patients. (<i>JAMA</i>. 1994;271:907-913)
Mycobacterium tuberculosisChaperonin 10 Heptamers Self-Associate through Their Biologically Active Loops (2003)

The crystal structure of Mycobacterium tuberculosis chaperonin 10 (cpn10(Mt)) has been determined to a resolution of 2.8 A. Two dome-shaped cpn10(Mt) heptamers complex through loops at their bases to form a tetradecamer with 72 symmetry and a spherical cage-like structure. The hollow interior enclosed by the tetradecamer is lined with hydrophilic residues and has dimensions of 30 A perpendicular to and 60 A along the sevenfold axis. Tetradecameric cpn10(Mt) has also been observed in solution by dynamic light scattering. Through its base loop sequence cpn10(Mt) is known to be the agent in the bacterium responsible for bone resorption and for the contribution towards its strong T-cell immunogenicity. Superimposition of the cpn10(Mt) sequences 26 to 32 and 66 to 72 and E. coli GroES 25 to 31 associated with bone resorption activity shows them to have similar conformations and structural features, suggesting that there may be a common receptor for the bone resorption sequences. The base loops of cpn10s in general also attach to the corresponding chaperonin 60 (cpn60) to enclose unfolded protein and to facilitate its correct folding in vivo. Electron density corresponding to a partially disordered protein subunit appears encapsulated within the interior dome cavity of each heptamer. This suggests that the binding of substrates to cpn10 is possible in the absence of cpn60.
Corrole‐Based Applications (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Understanding the Relationship between Cotton Fiber Properties and Non-Cellulosic Cell Wall Polysaccharides (2014)

A detailed knowledge of cell wall heterogeneity and complexity is crucial for understanding plant growth and development. One key challenge is to establish links between polysaccharide-rich cell walls and their phenotypic characteristics. It is of particular interest for some plant material, like cotton fibers, which are of both biological and industrial importance. To this end, we attempted to study cotton fiber characteristics together with glycan arrays using regression based approaches. Taking advantage of the comprehensive microarray polymer profiling technique (CoMPP), 32 cotton lines from different cotton species were studied. The glycan array was generated by sequential extraction of cell wall polysaccharides from mature cotton fibers and screening samples against eleven extensively characterized cell wall probes. Also, phenotypic characteristics of cotton fibers such as length, strength, elongation and micronaire were measured. The relationship between the two datasets was established in an integrative manner using linear regression methods. In the conducted analysis, we demonstrated the usefulness of regression based approaches in establishing a relationship between glycan measurements and phenotypic traits. In addition, the analysis also identified specific polysaccharides which may play a major role during fiber development for the final fiber characteristics. Three different regression methods identified a negative correlation between micronaire and the xyloglucan and homogalacturonan probes. Moreover, homogalacturonan and callose were shown to be significant predictors for fiber length. The role of these polysaccharides was already pointed out in previous cell wall elongation studies. Additional relationships were predicted for fiber strength and elongation which will need further experimental validation.
Enantiopure Isotactic PCHC Synthesized by Ring-Opening Polymerization of Cyclohexene Carbonate (2014)

The ring-opening polymerization (ROP) of racemic trans-cyclohexene carbonate (rac-CHC) and enantiopure trans-(R,R)-CHC is successfully carried out with various catalyst systems. Poly(cyclohexene carbonate) (PCHC) with a slight isotactic bias (Pm = ca. 60–76%) is obtained by ROP of rac-CHC catalyzed by zinc diaminophenolate, zinc β-diketiminate, yttrium bis(phenolate), or 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) in combination with an alcohol as a co-initiator. Purely isotactic PCHC is synthesized for the first time via ROP of enantiopure (R,R)-CHC with a zinc/benzyl alcohol catalyst system. All reactions proceed without decarboxylation, affording well-defined PCHCs with Mn,NMR up to 17 000 g mol–1 and ĐM = ca. 1.2. Purely isotactic PCHC is semicrystalline, with Tg = 130 °C, Tc = 162 °C, and Tm = 248 °C. DFT computations further highlight the significant favorable impact of the trans-cyclohexane ring-strain to enable the ROP of CHC, as opposed to meso-CHC which is unreactive.
Pyrazinone based hepatitis C virus NS3 protease inhibitors targeting genotype 1a, 3a and the drug-resistant enzyme variant R155K (2015)

Pyrazinone based hepatitis C virus NS3 protease inhibitors targeting genotype 1a, 3a and the drug-resistant enzyme variant R155K
Slot waveguide cavities for electrically-pumped silicon-based light sources (2008)

We fabricate horizontal slot waveguides and resonators using layers of polycrystalline and single crystalline silicon. We demonstrate waveguide propagation losses of 7.3 dB/cm and ring resonators with an intrinsic quality factor of 76,000.
STEPS toward the Right Direction (2009)

Cell therapy for stroke may benefit from translational from Hess and Kondziolka and a biostatistics data coor-research guidelines to aid its entry into the clinic as a dination center by Lu. These investigators highlight thesafe and effective treatment. Failures of clinical trials rationale for establishing such consortium and its pur-using neuroprotective drugs in stroke patients, despite pose for evaluating the therapeutic potential of cell ther-promising laboratory findings, led to conference meet- apy for stroke in the present commentary (2). In view ofings under the banner of Stroke Therapy Academic In- cell therapy being marketed as “medical tourism” arounddustry Round table, or STAIR, whose main goal was the world, and the lifting of the US federal ban on em-to formulate recommendations designed to enhance the bryonic stem cell research, which is likely to gain fur-success of translating preclinical research on neuropro- ther public attention and scrutiny with respect to thetection into clinical application. In 2007, a group of sci- safety and efficacy of this treatment, this raises the ur-entists from academia and industry with interest in cell gency for an orderly transition of laboratory findingstherapy and stroke, together with representatives from into the clinic. The preclinical STEPS group serves notthe National Institute on Neurological Disorders and as an impediment to clinical trials of restorative treat-Stroke (NINDS) and the Food and Drug Administration, ment, but rather as a consultative faculty of scientistsconvened to outline STAIR-like criteria called Stem cell and clinicians who possess the desire of optimizing theTherapeutics as an Emerging Paradigm in Stroke, or therapeutic potential and assuring the safety of cell ther-STEPS, that will serve as a guide in the conduct of labo- apy for stroke. Whereas the current affiliations of thisratory research and clinical trials of restorative therapies, STEPS consortium are limited to the US, the near-termin particular cell therapy for stroke (3). The preclinical goal is to receive memberships from academic, industry,arm of STEPS specifically calls for the use of appro- and legislative organizations worldwide working on re-priate species for stroke modeling, the need for standard- storative therapy.ization of functional tests and outcomes, the requirementfor cell imaging and tracking, the incorporation of safety
P587MiR-29a controls cardiac stem cells differentiation through Dnmt3a-mediated extinction of Wnt/beta-catenin (2014)

Epigenetic programming within the cardiac stem cell (CSC) niche controls CSC specification and differentiation, but the identity of putative mediators is poorly characterized. To dissect these mechanisms, we used primary and clonally expanded Sca-1+/c-kit+ CSC from murine adult hearts and stimulated cardiomyocyte differentiation upon culture in a differentiation medium (DIFF) containing 5'-Azacytidine and transforming growth factor β1 or co-cultured with rat cardiomyocytes. With this model, we previously showed that inducible deletion of β-catenin enhanced CSC differentiation in vitro and in vivo. Accordingly, we detected a constitutive activity of Wnt/b-catenin pathway in undifferentiated CSC and a downregulation of Wnt target genes (in % of ctl: Axin2: 36±4%; Snai2: 46±7%; n=3; p<0.01) in CSC treated with DIFF medium, associated with an upregulation of Wnt antagonist, Wif-1 (310±57%; n=3, p<0.05). Like several Wnt/b-catenin repressor genes, Wif-1 gene expression is DNA methylation sensitive and susceptible to be regulated by the de novo DNA methyltransferases Dnmt3. Indeed, Dnmt3a was downregulated in CSC treated with DIFF, while siRNA targeting Dnmt3a upregulated Wif-1 expression in non-differentiated cells (425±254%; n=4, p<0.05) and promoted CSC cardiac differentiation in co-culture assay (assessed by quantitative expression of cTnT; 162±7% vs. siRNA-scramble; n=7, p<0.001). In parallel, we found an early upregulation of miR-29a (444±43%; n=3, p<0.01), a well-known regulator of Dnmt3a, in DIFF-treated CSC. Indeed, early treatment of CSC with miR-29a mimic decreased Dnmt3a protein level and increased Wif-1 expression (839±257%; n=4, p<0.05). Reciprocally, CSC treatment with anti-miR-29a (LNA-miR-29a; vs scramble ctl) upregulated Dnmt3a and downregulated Wif-1 expression (51±9%; n=7, p<0.01). Importantly, this treatment also significantly decreased CSC differentiation in co-culture assay (63±4% vs. LNA-scramble; n=11, p<0.001). Altogether, this suggests that upregulation of miR-29a promotes differentiation (and blockade of miR-29a inhibits differentiation) through Dnmt3a-dependent regulation of the Wnt inhibitor, Wif-1. In support of this, co-treatment with anti-miR-29a and siRNA-Dnmt3a abrogates the above effect both on Wif-1 expression and CSC differentiation (compared to treatment with respective scramble, n=7). We conclude that differentiation of CSC involves the epigenetic regulation of canonical Wnt/β-catenin activity through miR-29a and Dnmt3a-dependent control of expression of the endogenous inhibitor, Wif-1, possibly amenable to therapeutic modulation for cardiac repair.
Síntesis de la Zeolita ITQ-33 (2007)

Referencia OEPM: P200500120.-- Fecha de solicitud: 17/01/2005.-- Titulares: Universidad Politécnica de Valencia (UPV), Consejo Superior de Investigaciones Científicas (CSIC).
Using Next-Generation Sequencing to Explore Genetics and Race in the High School Classroom (2017)

With the development of new sequencing and bioinformatics technologies, concepts relating to personal genomics play an increasingly important role in our society. To promote interest and understanding of sequencing and bioinformatics in the high school classroom, we developed and implemented a laboratory-based teaching module called "The Genetics of Race." This module uses the topic of race to engage students with sequencing and genetics. In the experimental portion of this module, students isolate their own mitochondrial DNA using standard biotechnology techniques and collect next-generation sequencing data to determine which of their classmates are most and least genetically similar to themselves. We evaluated the efficacy of this module by administering a pretest/posttest evaluation to measure student knowledge related to sequencing and bioinformatics, and we also conducted a survey at the conclusion of the module to assess student attitudes. Upon completion of our Genetics of Race module, students demonstrated significant learning gains, with lower-performing students obtaining the highest gains, and developed more positive attitudes toward scientific research.
Publisher Correction: Development of an optogenetic toolkit for neural circuit dissection in squirrel monkeys (2019)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Turbo greedy multiuser detection (2001)

Previously, a novel scheme for iterative multiuser detection and turbo decoding was proposed by Damnjanovic and Vojcic (2000, 2001). In this scheme, multiuser detection and single-user turbo decoding are tightly coupled to maximize the overall gain. The extrinsic probabilities for the coded bits of the interfering users, obtained after each turbo decoding iteration, are used as a priori probabilities in the following multiuser iteration and the extrinsic information for the systematic bits of the desired user is used as a priori information in the next single-user turbo decoding iteration. Turbo decoding of parallel concatenated convolutional codes is carried out in parallel fashion. It has been shown that the proposed detector approaches the multiuser capacity limit within 1 dB in the low signal-to-noise ratio region. However, the main drawback of the scheme is its exponential complexity in the number of users, which is due to the complexity of the maximum a posteriori probability (MAP) multiuser detector. In this paper, we show that the complexity of the scheme can be significantly reduced by replacing the (MAP) multiuser detector with an iterative detector derived from the greedy multiuser detector proposed by AlRustamani and Vojcic (2000). In this paper, we demonstrate that, for both the additive white Gaussian noise and the frequency-nonselective Rayleigh fading, the substantial reduction in complexity of the iterative scheme proposed by Damnjanovic and Vojcic when the greedy detector is utilized introduces a slight degradation in performance.
Shrinkage and Warpage (2016)

No AccessInjection Mold Design EngineeringApr 2016Shrinkage and WarpageDavid O. KazmerDavid O. Kazmerhttps://doi.org/10.3139/9781569905715.010SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF ShareFacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2016 Pages: 291-325Print ISBN: 978-1-56990-570-8eISBN: 978-1-56990-571-5 Copyright & Permissions© 2016 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
A wash-durable polyelectrolyte complex that extinguishes flames on polyester–cotton fabric (2016)

Polyester–cotton (PECO) blends were rendered flame retardant by depositing a stable polyelectrolyte complex as a wash-durable coating.
Bias-Temperature Instabilities and Radiation Effects on SiC MOSFETs (2011)

Bias-temperature-instabilities (BTIs) are investigated for 4H-SiC based nMOSFETs before and after total ionizing dose irradiation. We find that the threshold voltage shifts of unirradiated devices decrease significantly with elevated-temperature stress under accumulation bias; in contrast, devices stressed under inversion bias do not exhibit significant threshold voltage shifts. Threshold voltage shifts due to BTI for unirradiated devices stressed under accumulation bias may well be enhanced significantly as a result of the additional ionization of deep dopants in SiC at elevated temperatures. The BTIs are caused by charge carriers are captured by deep interface traps (more than 0.6 eV away from the SiC conduction or valence bands) and O vacancies in the SiO2. Hole trapping at O vacancies dominates the ionizing radiation response. The magnitudes of the changes in threshold voltage shifts increase with switched bias-temperature stress after irradiation, relative to those in unirradiated devices.
Implementation Issues for IPv6 Software Forwarding in Routing System (2006)

This paper considers software forwarding intending as the short solution for deploying IPv6 feature in the routing system which has already IPv4 hardware forwarding function. Linux Kernel forwards IPv6 packet through looking up the routing table being made from upper software blocks. Essentially we had to change each interface setup, forwarding base management and neighbor information control scheme. Considering the amount of current IPv6 traffic, the performance of IPv6 software forwarding is acceptable and this work is prototype for deploying IPv6 hardware forwarding.
New Method for Large-Scale Preparation of Covalently Closed λ DNA Molecules (1974)

A combination of mutations in bacteriophage lambda and its host Escherichia coli K-12 provides a convenient system for the isolation of large quantities of covalently closed circular DNA molecules. We describe two procedures for the large scale preparation of lambda DNA in the duplex circular form.
Development of environmentally friendly epoxy-resin compounds without toxic flame retardants and their application to electronic parts (2002)

We developed self-extinguishing epoxy-resin compounds that contain no environmentally hazardous flame-retardants such as halogen or phosphorous derivatives, and used these compounds to develop an integrated circuit (IC) molding compound and an insulating material for printed wiring boards (PWBs). The new epoxy-resin compounds consist mainly of phenol-aralkyl-type epoxy resins and hardeners; stable foam layers retard heat transfer and thus have self extinguishing properties. Especially beneficial is the fact that the IC molding compound based on the new compounds, can withstand higher temperatures required for lead-free soldering. The PWB also contains a limited amount of safe metal hydroxide.
Immunoprevention of Human Papillomavirus–Associated Malignancies (2014)

Persistent infection by one of 15 high-risk human papillomavirus (hrHPV) types is a necessary but not sufficient cause of 5% of all human cancers. This provides a remarkable opportunity for cancer prevention via immunization. Since Harald zur Hausen's pioneering identification of hrHPV types 16 and 18, found in approximately 50% and 20% of cervical cancers, respectively, two prophylactic HPV vaccines containing virus-like particles (VLP) of each genotype have been widely licensed. These vaccines are beginning to affect infection and HPV-associated neoplasia rates after immunization campaigns in adolescents. Here, we review recent progress and opportunities to better prevent HPV-associated cancers, including broadening immune protection to cover all hrHPV types, reducing the cost of HPV vaccines especially for developing countries that have the highest rates of cervical cancer, and immune-based treatment of established HPV infections. Screening based upon George Papanicolaou's cervical cytology testing, and more recently detection of hrHPV DNA/RNA, followed by ablative treatment of high-grade cervical intraepithelial neoplasia (CIN2/3) have substantially reduced cervical cancer rates, and we examine their interplay with immune-based modalities for the prevention and eventual elimination of cervical cancer and other HPV-related malignancies.
Efficient Free Energy Calculation of Biomolecules from Diffusion-Biased Molecular Dynamics (2012)

Recently proposed metadynamics techniques offer an effective means for improving sampling in simulations of complex systems, including polymers and biological macromolecules. One of the drawbacks of such methods has been the absence of well-defined or effective convergence criteria. A solution to this problem is considered here in which an optimal ensemble is introduced to minimize the travel time across the entire order parameter range of interest. The usefulness of the proposed approach is illustrated in the context of two systems consisting of biological molecules dissolved in water. The results presented in this work indicate that the proposed method is considerably faster than other existing algorithms for the study of these systems, and that the corresponding free energy that emerges from the simulations converges to the exact result.
Fast audio search using vector space modelling (2007)

Many techniques for retrieving arbitrary content from audio have been developed to leverage the important challenge of providing fast access to very large volumes of multimedia data. We present a two-stage method for fast audio search, where a vector-space modelling approach is first used to retrieve a short list of candidate audio segments for a query. The list of candidate segments is then searched using a word-based index for known words and a phone-based index for out-of-vocabulary words. We explore various system configurations and examine trade-offs between speed and accuracy. We evaluate our audio search system according to the NIST 2006 Spoken Term Detection evaluation initiative. We find that we can obtain a 30-times speedup for the search phase of our system with a 10% relative loss in accuracy.
A 5G Radio-Light SDN Architecture for Wireless and Mobile Network Access in Buildings (2018)

The Internet of Radio-Light architecture provides both direct WLAN type access to the Internet using 5G RAN as well as access to the Internet via Mobile Networks using a 5G mmWave and VLC Radio Access Network (RAN) within buildings. A SDN is used to manage the various different packet flows between the RAN, the Internet Interface and the Mobile Network User and Control plane interfaces for SmartPhone, Tablet PCs, HDTVs and Virtual Reality headsets within buildings.