gebhart/patrepeval huggingface dataset:
Higher Harmonic Anisotropic Flow Measurements of Charged Particles in Pb-Pb Collisions atsNN=2.76  TeV (2011)

We report on the first measurement of the triangular v3, quadrangular v4, and pentagonal v5 charged particle flow in Pb-Pb collisions at sqrt(s(NN)) = 2.76 TeV measured with the ALICE detector at the CERN Large Hadron Collider. We show that the triangular flow can be described in terms of the initial spatial anisotropy and its fluctuations, which provides strong constraints on its origin. In the most central events, where the elliptic flow v2 and v3 have similar magnitude, a double peaked structure in the two-particle azimuthal correlations is observed, which is often interpreted as a Mach cone response to fast partons. We show that this structure can be naturally explained from the measured anisotropic flow Fourier coefficients.
Figure S1 from JQ1 Induces DNA Damage and Apoptosis, and Inhibits Tumor Growth in a Patient-Derived Xenograft Model of Cholangiocarcinoma (2023)

&lt;p&gt;Patient-derived xenograft (PDX) models of cholangiocarcinoma (CCA): tumor growth and histology.&lt;/p&gt;
Vulnerable Atherosclerotic Carotid Plaque Evaluation by Ultrasound, Computed Tomography Angiography, and Magnetic Resonance Imaging: An Overview (2013)

Ischemic syndromes associated with carotid atherosclerotic disease are often related to plaque rupture. The benefit of endarterectomy for high-grade carotid stenosis in symptomatic patients has been established. However, in asymptomatic patients, the benefit of endarterectomy remains equivocal. Current research seeks to risk stratify asymptomatic patients by characterizing vulnerable, rupture-prone atherosclerotic plaques. Plaque composition, biology, and biomechanics are studied by noninvasive imaging techniques such as magnetic resonance imaging, computed tomography, ultrasound, and ultrasound elastography. These techniques are at a developmental stage and have yet to be used in clinical practice. This review will describe noninvasive techniques in ultrasound, magnetic resonance imaging, and computed tomography imaging modalities used to characterize atherosclerotic plaque, and will discuss their potential clinical applications, benefits, and drawbacks.
An accelerated method for the design of 2-D circularly symmetric FIR filters (2002)

A method to accelerate the design of 2-D circularly symmetric finite impulse response (FIR) filters is presented. This method utilizes the circular symmetry property and computes the elements of the impulse response using only the elements located on a half-axis in the space domain, i.e., h(m,0). h(m,n) can be computed using B-spline and piecewise Lagrange interpolation on h(m,0). When used in conjunction with nonlinear optimization, this method results in considerable reduction of execution time and lower sensitivity to the initial vector. This characteristic can be useful in higher-order filters where finding a suitable initial vector for a better local optimum becomes more difficult.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Long-distance electron transfer in pentaammineruthenium (histidine-48)-myoglobin. Reorganizational energetics of a high-spin heme (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLong-distance electron transfer in pentaammineruthenium (histidine-48)-myoglobin. Reorganizational energetics of a high-spin hemeRobert J. Crutchley, Walther R. Ellis Jr., and Harry B. GrayCite this: J. Am. Chem. Soc. 1985, 107, 17, 5002–5004Publication Date (Print):August 1, 1985Publication History Published online1 May 2002Published inissue 1 August 1985https://pubs.acs.org/doi/10.1021/ja00303a034https://doi.org/10.1021/ja00303a034research-articleACS PublicationsRequest reuse permissionsArticle Views167Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Design of an ICF plant using a nuclear-driven solid-state laser (1995)

An ICF plant is designed to use nuclear-driven flashlamp-pumped solid-state lasers as fusion drivers. It is proposed to use a separated fission reactor with aerosol fuel to drive alkali metal excimer flashlamps as the pumping source for solid-state lasers. The first observation of nuclear-excited sodium excimer emission at 436 nm in a TRIGA reactor with 815 Torr of He-3 and 60 Torr of sodium vapor (at T = 924 K) is reported. The experiment demonstrates the feasibility of a nuclear-driven alkali metal excimer lamp. The compatibility of alkali metal excimers with different laser crystals is evaluated for driver efficiency. High overall laser efficiency ensures large fractional output power extraction from nuclear fusion by this plant. The suitability of laser crystals for the ICF plant is also presented.
Further Evidence for Functional Heterogeneity of Adipocyte Insulin Receptors* (1979)

Dissociation of [125I]iodoinsulin from adipocyte insulin receptors was studied in the presence or absence of the insulin derivatives, desoctapeptide insulin and desalanine desasparagine insulin. When cells were allowed to associate with a tracer concentration (10-10 M) of [125I]iodoinsulin and dissociation was studied in either insulin-free buffer or buffer containing 100 ng/ml unlabeled insulin, dissociation was accelerated in the presence of unlabeled insulin. This is consistent with negatively cooperative site-site interactions. On the other hand, when dissociation studies were performed in the presence of high concentrations of desoctapeptide insulin or desalanine desasparagine insulin, dissociation rates were slower than those observed in insulin-free buffer. In marked contrast, when cells were allowed to achieve a high fractional receptor occupancy by associating with high concentrations of either desoctapeptide insulin or desalanine desasparagine insulin, subsequent dissociation rates were greatly enhanced. Thus, insulin derivatives which failed to induce the negative cooperative effect can lead to enhanced [125I]iodoinsulin dissociation, if high fractional receptor occupancy is achieved during the association phase of the experiment. This is consistent with the hypothesis that adipocyte receptors exist in functionally distinct, high affinity, low capacity and low affinity, high capacity states. Thus, when association is performed with [125I]iodoinsulin plus high concentrations of unlabeled insulin, dissociation rates are enhanced because most of the [125I]iodoinsulin binds to the low affinity (fast dissociating) sites, due to saturation of the high affinity, low capacity sites.
An Efficient Multigram Synthesis of the Potent Histamine H3 Antagonist GT-2331 and the Reassessment of the Absolute Configuration (2003)

GT-2331 is a potent histamine H(3) antagonist which has entered clinical trials. Efficient multigram syntheses of this compound and its enantiomer are described. The literature reports that GT-2331 is the dextrorotatory (+), more potent, enantiomer of 4-[2-(5,5-dimethylhex-1-ynyl)cyclopropyl]-1H-imidazole with the absolute configuration of (1R,2R)-1. However, we found that the dextrorotatory, more potent, enantiomer of 4-[2-(5,5-dimethylhex-1-ynyl)cyclopropyl]-1H-imidazole has the (1S,2S) absolute configuration. We suggest a reconsideration of the absolute configuration of GT-2331.
Sleep is required for odor exposure to consolidate memory and remodel olfactory synapses (2020)

SUMMARY Animals with complex nervous systems demand sleep for memory consolidation and synaptic remodeling. Here we show that though the Caenorhabditis elegans nervous system has a limited number of neurons, sleep is necessary for both processes. In addition, it is unclear in any system if sleep collaborates with experience to alter synapses between specific neurons and whether this ultimately affects behavior. C. elegans neurons have defined connections and well-described contributions to behavior. We show that spaced odor-training and post-training sleep induce long-term memory. Memory consolidation, but not acquisition, requires a pair of interneurons, the AIYs, which play a role in odor-seeking behavior. In worms that consolidate memory, both sleep and odor conditioning are required to diminish inhibitory synaptic connections between the AWC chemosensory neurons and the AIYs. Thus, we demonstrate in a living organism that sleep is required for events immediately after training that drive memory consolidation and alter synaptic structures.
Multipurpose gadolinium-based ligand DO3A-EA as precursor for conjugation with organic molecules to develop smart and targeted contrast agents for MR and optical imaging (2005)

Introduction Smart MR contrast agents (CA) exhibit modulation of their relaxivity by specific physiological or biochemical trigger-events. In an effort to develop novel smart MR contrast agents, the multifunctional chelating agent DO3A-EA has been synthesized. It serves as a valuable multipurpose precursor for smart contrast agents based on Gadolinium chelates in the design of relaxometric MR probes. Synthesis 1,4,7-tris(carboxymethyl)10-(aminoethyl)-1,4,7,10-tetraazacyclododecane (DO3A-EA) was synthesized from cyclen by the reaction of tert-butylbromoacetate to get the tri-substituted product. It was further reacted with N-Boc-2-bromoethylamine to get 1,4,7-tris(carbobutoxymethyl)-10-(Boc-aminoethyl)-1,4,7,10 tetraazacyclododecane. The corresponding carboxylate derivative DO3A-EA was obtained by cleaving the tert-butyl groups by the treatment of DCM/TFA at RT. Yield was 85. Results With DO3A-EA as precursor, following CAs were synthesized and tested: Gd-DO3A-E-NCS: It forms stable macrocyclic complex with Gd(III) and can be used in Gd-preloading approach to avoid the binding of gadolinium with calcium binding chelates. MR relaxivity of Gd-DO3A-E-NCS (pH 7.5) was r1 = (3.29 ± 0.08) s-1mM-1. Gd-DO3A-E-biotin: It can be used for targeted imaging in an antibody-avidin system. MR relaxivity of Gd-DO3A-E-biotin (pH 7.5) was r1 = (4.85 ± 0.08) s-1mM-1. Mixture of Gd-DO3A-E-biotin and avidin (4:1) showed 30 relaxivity enhancement for r1 and 311 for r2 relative to the unbound biotinylated Gd(III) complex. DO3A-E-FITC: It can be used to track cellular binding and internalization. Additional loading with Gd3+ can provide MR contrast. DO3A-E-FITC and Eu-DO3A-E-FITC up to 50 μM did not show cytotoxicity after treatment for 24 hrs (NIH-3T3 cells, PI assay). Fluorescence microscopy of living cells displayed proper co-localization.
ChemInform Abstract: VERRUCARINS AND RORIDINS. 35. PARTIAL SYNTHESIS OF TETRAHYDROVERRUCARIN J (1979)

Abstract Ausgehend von Verrucarol (Ia) bzw. seinem Acetylderivat (Ib) und der Säure (IIc) (erhältlich aus dembekannten Ester (IIa) über (IIb) wird über die Stufe (IIIa) die Verbindung (IIIb) (E/Z‐Gemisch) dargestellt, die mit dem leicht zugänglichen Adipinsäureester (IV) zur Schlüsselverbindung (VI) (E/Z‐Gemisch) kondensiert wird.
Single‐dose pharmacokinetics of felbamate in patients with renal dysfunction (1997)

These data suggest that initial dosage and titration of felbamate may require adjustment in patients with renal dysfunction.
All electrical propagating spin wave spectroscopy with broadband wavevector capability (2016)

We developed an all electrical experiment to perform the broadband phase-resolved spectroscopy of propagating spin waves in micrometer sized thin magnetic stripes. The magnetostatic surface spin waves are excited and detected by scaled down to 125 nm wide inductive antennas, which award ultra broadband wavevector capability. The wavevector selection can be done by applying an excitation frequency above the ferromagnetic resonance. Wavevector demultiplexing is done at the spin wave detector thanks to the rotation of the spin wave phase upon propagation. A simple model accounts for the main features of the apparatus transfer functions. Our approach opens an avenue for the all electrical study of wavevector-dependent spin wave properties including dispersion spectra or non-reciprocal propagation.
Divide-and-Conquer Adversarial Detection. (2019)

The vulnerabilities of deep neural networks against adversarial examples have become a major concern for deploying these models in sensitive domains. Devising a definitive defense against such attacks is proven to be challenging, and the methods relying on detecting adversarial samples have been shown to be only effective when the attacker is oblivious to the detection mechanism, i.e., in non-adaptive attacks. In this paper, we propose an effective and practical method for detecting adaptive/dynamic adversaries. In short, we train adversary-robust auxiliary detectors to discriminate in-class natural examples from adversarially crafted out-of-class examples. To identify a potential adversary, we first obtain the estimated class of the input using the classification system, and then use the corresponding detector to verify whether the input is a natural example of that class, or is an adversarially manipulated example. Experimental results on MNIST and CIFAR10 dataset show that our method could withstand adaptive PGD attacks. Furthermore, we demonstrate that with our novel training scheme our models learn significant more robust representation than ordinary adversarial training.
Supplementary Figures: Lack of p53 Augments Anti-Tumor Functions in Cytolytic T Cells from Lack of <i>p53</i> Augments Antitumor Functions in Cytolytic T Cells (2023)

&lt;p&gt;Details for comparative characterization of phenotype and anti-tumor function between the p53-KO vs. WT T cells are included.&lt;/p&gt;
Specific synbiotics in early life protect against diet‐induced obesity in adult mice (2018)

Together, these findings show the potential and importance of timing of synbiotic interventions in early life during crucial microbiota development as a preventive measure to lower the risk of obesity and improve metabolic health throughout life.
The development of specific rRNA-derived oligonucleotide probes for Haemophilus ducreyi, the causative agent of chancroid (1991)

Part of a ribosomal ribonucleic acid (rRNA) cistron of Haemophilus ducreyi was enzymically amplified using conserved primers within the rRNA molecules, cloned in a plasmid vector, and sequenced. From the nucleotide sequence, eight oligonucleotides complementary to different regions in the 16S and 23S rRNA molecules were selected, chemically synthesized, and used as hybridization probes. Hybridization experiments with at least 41 H. ducreyi strains and 13 or 14 non-H. ducreyi strains revealed that all eight oligonucleotide probes were highly reliable and completely specific for H. ducreyi strains. Comparisons of 16S rRNA sequences confirm that H. ducreyi is a member of the Pasteurellaceae though not closely related to other species in this family.
UPTAKE AND DEGRADATION OF A SYNTHETIC COPOLYMER BY RAT VISCERAL YOLK SACS CULTURED IN VITRO (1981)

Conference Abstract| April 01 1981 UPTAKE AND DEGRADATION OF A SYNTHETIC COPOLYMER BY RAT VISCERAL YOLK SACS CULTURED IN VITRO R. Duncan; R. Duncan 1Dept. Biological Sciences, University of Keele, Staffs., England Search for other works by this author on: This Site PubMed Google Scholar J. Kopeček; J. Kopeček *Institute of Macromol. Chem., Prague, Czechoslovakia Search for other works by this author on: This Site PubMed Google Scholar J. B. Lloyd J. B. Lloyd 1Dept. Biological Sciences, University of Keele, Staffs., England Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1981) 9 (2): 261P. https://doi.org/10.1042/bst009261pd Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation R. Duncan, J. Kopeček, J. B. Lloyd; UPTAKE AND DEGRADATION OF A SYNTHETIC COPOLYMER BY RAT VISCERAL YOLK SACS CULTURED IN VITRO. Biochem Soc Trans 1 April 1981; 9 (2): 261P. doi: https://doi.org/10.1042/bst009261pd Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1981 Biochemical Society1981 Article PDF first page preview Close Modal You do not currently have access to this content.
Abstract LB-403: Recurrent fusion transcripts in breast cancer (2012)

Abstract Breast cancer is the second leading cause of cancer deaths among women in the United States. Genome wide analyses in primary breast tumors and ∼50 breast cancer cell lines using gene expression profiling revealed subsets defined as luminal, basal-like, ERBB2 and claudin-low. The general hypothesis is that recurrent fusion transcripts exist and play a central role in the pathophysiology and clinical outcome of breast cancer. We identified recurrent fusion transcripts specific to breast cancer cell lines by performing Solexa based paired-end sequencing of whole-transcriptome (RNAseq) using 9 basal, 9 luminals, 4 ERBB2 and 1 claudin-low breast cancer cell lines. In addition, we cross-compared the predicted fusion transcripts with that of copy number and gene expression changes in the respective cell lines and performed gene ontology (GO) based enrichment analysis using the genes that were involved in the fusion. The sequencing of 19 breast cancer cell lines resulted in a range of ∼15 million to ∼45 million paired-end reads of 76 bp per cell line and out of which 93% to 98.6% had quality reads. On average, we predicted ∼14 fusion genes per cell lines (331 fusion genes in total) that are expressed atleast in one cell line. Interestingly, basal breast cancer cell lines on average have more number of fusion transcripts (∼13 per cell line and 115 in total) whereas luminal cell lines have only ∼9 predicted fusion transcripts per cell line (84 in total). Among the 418 unique genes that were involved in fusion processes, 20% of the genes occurred atleast twice and GO enrichment analysis show similar terms to be significantly enriched. Intriguingly, we identified 24 different recurrent fusion transcripts in total. In summary, the data demonstrates that there is more number of predicted fusion transcripts in breast cancer than initially thought. Also, the data suggest that genes with similar functions or processes fuse together. Currently studies are in progress to test if recurrent gene fusions may have a functional role, which may assist in the design of appropriate strategies to target recurrent events, and may be associated with poor outcome of basal breast cancers. Overall, this may improve the prognosis of breast cancer patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-403. doi:1538-7445.AM2012-LB-403
Robust Design of Power Minimizing Symbol-Level Precoder under Channel\n Uncertainty (2018)

In this paper, we investigate the downlink transmission of a multiuser\nmultiple-input single-output (MISO) channel under a symbol-level precoding\n(SLP) scheme, having imperfect channel knowledge at the transmitter. In\ndefining the SLP problem, a general category of constructive interference\nregions (CIR) called distance preserving CIR (DPCIR) is adopted. In particular,\nwe are interested in the robust SLP design minimizing the total transmit power\nwhile satisfying the users' quality-of-service (QoS) requirements. We consider\ntwo common models for the channel uncertainty region, namely, norm-bounded\nspherical and stochastic. For the spherical uncertainty model, a worst-case\nrobust precoder is proposed, while for the stochastic uncertainties, we define\na convex optimization problem with probabilistic constraints. We simulate the\nperformance of the proposed robust approaches, and compare them with the\nexisting methods. Through the simulation results, we also show that there is an\nessential trade-off between the two robust approaches.\n
Influence of Free Volume Change on the Relative Permittivity and Refractive Index in Fluoropolyimides (1996)

The often observed decrease in relative permittivity (ε‘) and refractive index (n) that accompanies fluorine substitution is the result of several effects. Fluorine replacement for hydrogen is known to decrease local electronic polarization and is thought to frequently increase fractional free volume. Both of these effects can independently decrease ε‘ and n, and this paper attempts to assign the observed decreases between these mechanisms for a series of hydrogen/fluorine polyimide analogs.
Polycan suppresses osteoclast differentiation and titanium particle‐induced osteolysis in mice (2015)

Particle-induced osteolysis is a major issue, and it is most likely the result of enhanced osteoclast activation in the pathogenesis of various skeletal diseases. This study investigated whether the inhibitory effect that Polycan has on osteoclast differentiation can be used to treat osteolysis induced by titanium (Ti) particles. To this end, the effects of Polycan were examined in terms of the cytotoxicity, osteoclast differentiation, cytokine expression, and Ti-induced calvarial osteolysis. Polycan had no significant cytotoxic effects on bone marrow macrophages (BMMs) but instead increased BMM proliferation. High levels of interleukin (IL)-6, IL-12, and macrophage colony-stimulating factor (M-CSF) were expressed in BMM cells in the presence of Polycan, suggesting that Polycan drives the differentiation of BMMs into M1 macrophages. Polycan significantly inhibited osteoclast differentiation induced by M-CSF and the receptor activator of nuclear factor kappa-B ligand (RANKL). The expression levels of the osteoclast marker genes significantly decreased, and Polycan induced and maintained the expression of IL-12, which suppressed osteoclast differentiation. In contrast, the RANKL signaling pathway was not inhibited by Polycan. An in vivo calvarial osteolysis model revealed that Polycan significantly decreased the osteoclast numbers and suppressed osteolysis. Our results suggest that the natural compound Polycan is a good candidate for therapeutic intervention against enhanced osteoclast differentiation and Ti particle-induced osteolysis. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1170-1175, 2016.