gebhart/patrepeval huggingface dataset:
Dynamic pH barrage junction focusing of amino acids, peptides, and digested monoclonal antibodies in capillary electrophoresis–mass spectrometry (2020)

Dynamic pH barrage junction focusing in CE enables effective signal enhancement, quantitative capture efficiencies, and straightforward optimization. The method is a technical variant of dynamic pH junction focusing. CE separation with dynamic pH barrage junction focusing is compatible with both optical and mass spectrometric detection. We developed a CE-MS/MS method using hydrophilic polyethyleneimine-coated capillaries and validated it for the qualitative analysis of amino acids, peptides, and tryptic peptides of digested monoclonal antibodies. The S/N of extracted ion electropherograms of zwitterionic analytes were enhanced by approximately two orders of magnitude with a tradeoff of a shortened separation window. Online focusing improved the MS signal intensity of a diluted antibody digest, enabling more precursor ions to be analyzed with subsequent tandem mass spectrometric identification. It also broadened the concentration range of protein digest samples for which adequate sequence coverage data can be obtained. With only 0.9 ng of digested infliximab sample loaded into the capillary, 76% and 100% sequence coverage was realized for antibody heavy and light chains, respectively, after online focusing. Full coverage was achieved with 9 ng of injected digest.
Soluble Polymeric Drug Carriers: Haematocompatibility (1991)

Soluble polymeric drug-carriers developed for parenteral use may be administered intravenously, intraperitoneally or subcutaneously. Intravenous administration brings the drug-carrier into immediate contact with blood, and the cells contained therein. Administration via the other routes will also ultimately result in transfer of the polymer conjugate into the circulation. Haematocompatibi1ity of polymeric drug carriers has not been widely explored, the term haematocompatibi1ity referring to both the potential toxicological effects that the carrier may induce on arrival in the circulation, and the additional possibility that presence in the bloodstream may interfere with the ability of the drug carrier to target and/or control the rate of delivery of the drug payload. Various aspects of haematocompatibility are discussed and experimental techniques which may prove useful to define specific parameters are described.
Mobile TV Business Eco‐System (2009)

This chapter contains sections titled: The Network of Dependencies in Mobile TV Business Mobile TV Business Roles Vertical Business Model, Mobile Operator-Driven Model Virtual Network Operator Model, Mobile Operator Operator-Driven Model Wholesaler–Reseller Model, Broadcast Network Operator-Driven Model NewCo or Consortium – Broadcaster-Driven Model Revenue Models Broadcast Network as Starting Point
Purification and Properties of Two Endocellulases fromPenicillium purpurogenum (1986)

Journal Article Purification and Properties of Two Endocellulases from Penicillium purpurogenum Get access Yoichi Kamagata, Yoichi Kamagata Present address: Fermentation Research Institute, Yatabe-machi Higashi, Ibaraki 305, Japan. Search for other works by this author on: Oxford Academic Google Scholar Makoto Yachi, Makoto Yachi Department of Agricultural Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo 060, Japan Search for other works by this author on: Oxford Academic Google Scholar Hiroshi Sasaki, Hiroshi Sasaki Department of Agricultural Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo 060, Japan Search for other works by this author on: Oxford Academic Google Scholar Shoichi Takao Shoichi Takao Department of Agricultural Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo 060, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 50, Issue 12, 1 December 1986, Pages 2989–2995, https://doi.org/10.1080/00021369.1986.10867876 Published: 01 December 1986 Article history Received: 18 April 1986 Published: 01 December 1986
Activity of Ingavirin (6-[2-(1H-Imidazol-4-yl)ethylamino]-5-oxo-hexanoic Acid) Against Human Respiratory Viruses in in Vivo Experiments (2011)

Respiratory viral infections constitute the most frequent reason for medical consultations in the World. They can be associated with a wide range of clinical manifestations ranging from self-limited upper respiratory tract infections to more devastating conditions such as pneumonia. In particular, in serious cases influenza A leads to pneumonia, which is particularly fatal in patients with cardiopulmonary diseases, obesity, young children and the elderly. In the present study, we show a protective effect of the low-molecular weight compound Ingavirin (6-[2-(1H-imidazol-4-yl)ethylamino]-5-oxohexanoic acid) against influenza A (H1N1) virus, human parainfluenza virus and human adenovirus infections in animals. Mortality, weight loss, infectious titer of the virus in tissues and tissue morphology were monitored in the experimental groups of animals. The protective action of Ingavirin was observed as a reduction of infectious titer of the virus in the lung tissue, prolongation of the life of the infected animals, normalization of weight dynamics throughout the course of the disease, lowering of mortality of treated animals compared to a placebo control and normalization of tissue structure. In case of influenza virus infection, the protective activity of Ingavirin was similar to that of the reference compound Tamiflu. Based on the results obtained, Ingavirin should be considered as an important part of anti-viral prophylaxis and therapy.
Extension to the Rude-CSMA Analysis (1987)

This paper extends the rude-CSMA analysis by removing the restriction that each node have the same average arrival rate and average service time. Additionally, some minor errors are corrected.
Anti-Inflammatory and Anti-Thrombotic Effects of the Fungal Metabolite Galiellalactone in Apolipoprotein E-Deficient Mice (2015)

Patients suffering from chronic inflammatory diseases have an increased mortality risk resulting from cardiovascular disorders due to enhanced atherosclerotic and thrombotic events. Until now, it is not completely understood in which way an abnormal expression of pro-inflammatory mediators contributes to this elevated cardiovascular risk, but there is a need for new drugs that on the one hand suppress the expression of pro-inflammatory mediators and on the other hand inhibit arterial platelet adhesion. Thus, we analyzed the anti-inflammatory and anti-thrombotic capacity of the fungal metabolite Galiellalactone in atherosclerosis-prone apolipoprotein E-deficient mice. Treatment of the mice with Galiellalactone lowered the inflammatory expression profile and improved blood clotting times, as well as platelet adhesion to the injured common carotid artery. The results indicate that administration of Galiellalactone is able to reduce the extent of inflammation and arterial platelet adhesion in this mouse model.
COST-EFFECTIVENESS ANALYSIS OF THIOPURINE METHYLTRANSFERASE (TPMT) SCREENING AND METABOLITE MONITORING (MM) IN THE MANAGEMENT OF AZATHIOPRINE (AZA)—TREATED CROHNʼS DISEASE (CD) PATIENTS (2003)

s Submitted for the 68th Annual Scientific Meeting of the American College of Gastroenterology October 10-15, 2003, Baltimore, Maryland: OUTCOMES RESEARCH: PDF Only
Model Evidence with Fast Tree Based Quadrature (2020)

High dimensional integration is essential to many areas of science, ranging from particle physics to Bayesian inference. Approximating these integrals is hard, due in part to the difficulty of locating and sampling from regions of the integration domain that make significant contributions to the overall integral. Here, we present a new algorithm called Tree Quadrature (TQ) that separates this sampling problem from the problem of using those samples to produce an approximation of the integral. TQ places no qualifications on how the samples provided to it are obtained, allowing it to use state-of-the-art sampling algorithms that are largely ignored by existing integration algorithms. Given a set of samples, TQ constructs a surrogate model of the integrand in the form of a regression tree, with a structure optimised to maximise integral precision. The tree divides the integration domain into smaller containers, which are individually integrated and aggregated to estimate the overall integral. Any method can be used to integrate each individual container, so existing integration methods, like Bayesian Monte Carlo, can be combined with TQ to boost their performance. On a set of benchmark problems, we show that TQ provides accurate approximations to integrals in up to 15 dimensions; and in dimensions 4 and above, it outperforms simple Monte Carlo and the popular Vegas method.
Sub 0.5 V Operation of Performance Driven Mobile Systems Based on Area Scaled Tunnel FET Devices (2013)

Advanced mobile applications demand low power and high performance systems. In this paper, a technology computer aided design (TCAD)-based feasibility investigation of a recently proposed area tunneling field effect transistor (FET) structure is carried out from the point of high volume and ultralow power mobile applications. We demonstrate that for realization of future ultralow power and high performance systems, unique properties of area tunneling class of tunnel FET structures need to be employed. These devices are realized by engineering the tunneling region profile and tunneling cross-sectional area. The optimized devices are found to leverage up to ~ 7× energy reduction when compared with the 20-nm node MOS device options while meeting the high performance targets. Device design insights for such an area tunneling class of tunnel FET structures are discussed in this paper for the first time. It is shown that by lowering the supply voltage below 0.5 V, up to 10× reduction of the energy delay product is feasible by using area tunneling devices.
Efficient generation of THz pulses with 04 mJ energy (2014)

Efficient generation of THz pulses with high energy was demonstrated by optical rectification of 785-fs laser pulses in lithium niobate using tilted-pulse-front pumping. The enhancement of conversion efficiency by a factor of 2.4 to 2.7 was demonstrated up to 186 μJ THz energy by cryogenic cooling of the generating crystal and using up to 18.5 mJ/cm2 pump fluence. Generation of THz pulses with more than 0.4 mJ energy and 0.77% efficiency was demonstrated even at room temperature by increasing the pump fluence to 186 mJ/cm2. The spectral peak is at about 0.2 THz, suitable for charged-particle manipulation.
Time-delayed, time-resolved Langmuir probe diagnostics of pulsed plasmas (2005)

A method called time-delayed, time-resolved Langmuir probe measurement is used to measure pulsed plasmas to overcome the secondary electron emission during high-voltage pulses. The plasma densities of the pulsed-mode plasma or any plasmas with secondary electron issues can be measured and analyzed by using this method.
Silicon Nitride 1×8 Power Splitter for Mid-Infrared Applications (2014)

We present a silicon nitride 1×8 power splitter based on a multimode interference coupler for mid infrared wave applications. Simulation shows a 9.3 dB insertion loss over a broad wavelength range (70 nm).
Desenvolvendo Objetos de Aprendizagem Utilizando um Processo Adaptado para Software Educativo (2010)

Este trabalho apresenta a proposta de customizacao de um processo para o desenvolvimento de software educativo, utilizando os principios das metodologias ageis e a prescricao do Processo Unificado. A pesquisa teve a participacao do GTA (Grupo de Trabalho Agil) que estuda a melhoria de processo de software. O processo resultante P@PSEduc (Processo Agil para Software Educativo) esta sendo utilizado para orientar o desenvolvimento de Objetos de Aprendizagem no Curso de Sistemas de Informacao.
Comparison of prostate cancer diagnosis in patients receiving unrelated urological and non‐urological cancer care (2013)

Rates of prostate cancer diagnosis were higher in patients with RCC (a cohort with unrelated urological cancer care) than in those with CRC. Despite higher overall mortality in patients with RCC, prostate cancer-specific survival was similar in both groups. Opportunities may exist to better target prostate cancer screening in patients who receive non-prostate-related urological care. Furthermore, urologists should not feel obligated to perform prostate-specific antigen screening for all patients receiving non-prostate-related urological care.
Design of an optimized time-resolved diffuse optical tomography probe to achieve deep absorption contrast reconstruction in a cylindrical geometry (2013)

We design a Time-Resolved (TR) instrumentation coupled with a reconstruction method based on Mellin-Laplace Transform (MLT) to accurately assess in depth absorption and diffusion maps of a cylindrical diffusive medium. To deal with experimental large TR dataset, MLT processing is handled without expressing the sensitivity matrix. Moreover an optimization of the TR probe geometry is performed to limit the number of measurements while keeping the sensitivity of the system. Simulations show how to optimize the probe geometry for specific inclusions depth given a background diffusing medium. These results lead to an experimental bench we use to perform experimental validations. This includes a femtosecond laser coupled with an HRI and a CCD camera.
Cover Picture: Transformation of Carbon Dioxide with Homogeneous Transition‐Metal Catalysts: A Molecular Solution to a Global Challenge? (Angew. Chem. Int. Ed. 37/2011) (2011)

The activation of carbon dioxide is one of the major tasks of catalysis today. CO2 is a ubiquitous and cheap C1 feedstock for the synthesis of raw and fine chemicals, yet its use as a reactant in industrial synthesis is comparatively scarce. The transformation of CO2 into acids, esters, lactones, and polymers with molecular transition-metal catalysts is a future alternative application. B. Rieger, F. E. Kühn et al. present the current catalysts and products in their Review on page 8510 ff.
Mode multiplexing/demultiplexing by fiber mode selective couplers and MIMO signal processing (2014)

The use of the fiber mode selective coupler (MSC) for mode multiplexing and demultiplexing is investigated. The signals in two separate modes excited by the MSCs are successfully recovered by 4×4 MIMO signal processing.
Bacteriochlorophylls-d from Chlorobium vibrioforme: chromatographic separations and structural assignments of the methyl bacteriopheophorbides (1985)

Bacteriochlorophylls-d (2) have been isolated from Chlorobium vibrioforme forma thiosulfatophilum, a green sulphur bacterium. Treatment of the bacteriochlorophylls with sulphuric acid in methanol affords the methyl bacteriopheophorbides (1) which are separated by high performance liquid chromatography (h.p.l.c.) into six major homologous fractions differing in the nature of 4-(ethyl, n-propyl, isobutyl) and 5-(methyl, ethyl) substituents. Using a combination of h.p.l.c., n.m.r., and X-ray crystallography, the 4-ethyl and 4-n-propyl homologues (1a), (1b), (lc), and (1f) are shown to have the (R) absolute stereochemistry at the 2-(1-hydroxyethyl) substituent while the 4-isobutyl compounds (lc) and (1g) are shown to have the opposite (S) chirality at this position. Two new methyl bacteriopheophorbides-d bearing a 4-neopentyl substituent (1d) and (1h) are isolated and characterized; these appear to be the first natural products with a neopentyl substituent to be isolated and are also assigned the (S) absolute stereochemistry at the 2-position on the basis of n.m.r., h.p.l.c., and X-ray structural evidence. The methyl bacteriopheophorbides-d from a new strain of green sulphur bacteria [Chlorobium vibrioforme(B1-20)] have also been studied; initially, these bacteria, which possess an abnormally short wavelength absorption in living cells, appeared to be producing major amounts of only two methyl bacteriopheophorbides-d (la) and (1e), but after they had grown continually for more than a year, the pigment composition began to contain larger quantities of more highly methylated homologues. The bacteriopheophorbides with R4= Et and R4= Bui again had the (R) and (S) absolute stereochemistries, respectively, at the 2-position, but the chirality at the 2-(1-hydroxyethyl) group in the homologues with R4= Prn is shown to be a mixture of both (R) and (S), this situation resembling that in the bacteriopheophorbides-c.
Cellulose solubilities in carboxylate-based ionic liquids (2012)

The dissolution of cellulose allows easier processing of this important biogenic feedstock. For this, ionic liquids have been proposed. Carboxylate-based ionic liquids were identified as the most promising lead towards a high dissolution property. Three homologous series of all 27 combination of the three cations: 1-ethyl-3-methylimidazolium, 1,3-dimethylimidazolium, and N,N-diethyl-N,N-dimethylammonium with nine carboxylates as anions were synthesised. The cellulose solubilities of the 17 ionic liquid compounds (liquid below 373 K) were measured. Up to 18 wt% for 1-ethyl-3-methyl-imidazolium propionate was achieved, slightly higher than when using acetate as the anion. Generally, the solubilities determined for carboxylate-based ionic liquids with imidazolium cations were found to be in the same range, whereas those with quaternary ammonium cations were found to be poor solvents for cellulose. Dicarboxylates gave higher solubilities compared to monocarboxylates. Regenerated ionic liquids had no apparent difference to fresh ones.
NovelS-Xanthenyl Protecting Groups for Cysteine and Their Applications for theNα-9-Fluorenylmethyloxycarbonyl (Fmoc) Strategy of Peptide Synthesis1-3 (1997)

The 9H-xanthen-9-yl (Xan) and 2-methoxy-9H-xanthen-9-yl (2-Moxan) groups can be introduced onto sulfhydryl functions by S-alkylation reactions involving the corresponding xanthydrols, plus trifluoroacetic acid (TFA) as catalyst. Conversely, these groups are removed rapidly by acid in the presence of appropriate silane or thiol scavengers. The 3-methoxy-9H-xanthen-9-yl (3-Moxan) derivative was also studied, but abandoned for several reasons including challenging synthesis, excessive lability to acid, and insufficient stability in the presence of base. The Nα-9-fluorenylmethyloxycarbonyl (Fmoc), S-Xan or 2-Moxan-protected cysteine derivatives were prepared and applied to the solid-phase syntheses of several model peptides. Selective removal of S-Xan and S-2-Moxan groups, while retaining tris(alkoxybenzyl)amide (PAL) anchoring, is best accomplished with TFA−CH2Cl2−Et3SiH (1:98.5:0.5), 25 °C, 2 h. Alternatively, oxidative deprotection of S-Xan or S-2-Moxan with iodine (10−20 equiv) or thallium(III) tris(trifluoroacetate) [Tl(tfa)3] (1−3 equiv) to provide disulfides can be carried out on peptide substrates both in solution and while polymer-bound. Compared to established chemistries with the acid-labile and oxidizable S-triphenylmethyl (Trt) group, S-Xan and S-2-Moxan gave equal or superior results in terms of peptide purities (including no detectable tryptophan alkylation) and overall yields.
Wireshark Primer (2022)

This chapter introduces you to Wireshark and covers basics of the tool, packet capture, and display and filtering techniques. Some of the topics covered in this chapter will be discussed in detail in subsequent chapters. The following is a summary of the concepts you will learn in this chapter:
In Vivo Hemostatic Effect of the Medicinal Plant Extract Ankaferd Blood Stopper in Rats Pretreated With Warfarin (2008)

ABS has in vivo hemostatic actions that may provide a therapeutic potential for the management of patients with deficient primary hemostasis in clinical medicine.
Processing and characterization of a polylactic acid/nanoclay composite for laser sintering (2015)

In this work, the feasibility of processing polylactic acid (PLA) and a PLA/nanoclay composite by laser sintering (LS) were investigated. The morphology of both the PLA and PLA/nanoclay powder was examined by scanning electron microscopy. LS process parameters, especially powder bed temperature, laser power, and laser scan count were studied. The effect of the addition of nanoclay on the thermal and flexural properties of LS PLA parts was examined. The results showed that PLA/nanoclay required a lower processing powder bed temperature compared with neat PLA. Under the same powder bed temperature, PLA/nanoclay parts exhibited an improvement in flexural modulus compared with neat PLA. Flexural modulus was increased significantly with double scan for both neat PLA and PLA/nanoclay LS parts. POLYM. COMPOS., 38:2570–2576, 2017. © 2015 Society of Plastics Engineers
Novel Organosoluble Poly(amide‐imide)s Derived from Kink Diamine Bis[4‐(4‐trimellitimidophenoxy)phenyl]‐diphenylmethane. Synthesis and Characterization (2001)

A new kink diimide-dicarboxylic acid, 2,2-bis[4-(4-trimellitimidophenoxy)phenyl]diphenylmethane (BTPDM), was synthesized by the condensation reaction of bis[4-(4-aminophenoxy)phenyl]diphenylmethane (BAPDM) with trimellitic anhydride. A series of new poly(amide-imide)s were prepared by direct polycondensation of BTPDM and various aromatic diamines in N-methyl-2-pyrrolidinone (NMP) using triphenyl phosphite and pyridine as condensing agents. The polymers were produced in high yield revealing moderate to high inherent viscosities of 0.80–0.89 dL·g–1. Wide-angle X-ray diffractograms revealed that the polymers are amorphous. Most of the polymers exhibit good solubility and could be readily dissolved in various solvents such as NMP, N,N-dimethylacetamide (DMAc), N,N-dimethylformamide, dimethyl sulfoxide, pyridine, cyclohexanone and tetrahydrofuran. These poly(amide-imide)s have glass transition temperatures between 244–248°C and show 10% weight loss in the range of 453–469°C under a nitrogen atmosphere. The tough polymer films, obtained by casting from DMAc solution, had tensile strengths ranging between 82 and 95 MPa and tensile moduli ranging between 1.7 and 1.9 GPa.
Password-protected secret sharing (2011)

We revisit the problem of protecting user's private data against adversarial compromise of user's device(s) which store this data. We formalize the solution we propose as Password-Protected Secret-Sharing (PPSS), which allows a user to secret-share her data among n trustees in such a way that (1) the user can retrieve the shared secret upon entering a correct password into a reconstruction protocol, which succeeds as long as at least t+1 uncorrupted trustees are accessible, and (2) the shared data remains secret even if the adversary which corrupts t trustees, with the level of protection expected of password-authentication, i.e. the probability that the adversary learns anything useful about the secret is at most q/|D| where q is the number of reconstruction protocol the adversary manages to trigger and |D| is the size of the password dictionary. We propose an efficient PPSS protocol in the PKI model, secure under the DDH assumption, using non-interactive zero-knowledge proofs with efficient instantiations in the Random Oracle Model. Our protocol is practical, with fewer than 16 exponentiations per trustee and 8t+17 exponentiations per user, with O(1) bandwidth between the user and each trustee, and only three message flows, implying a single round of interaction in the on-line phase. As a side benefit our PPSS protocol yields a new Threshold Password Authenticated Key Exchange (T-PAKE) protocol in the PKI model with significantly lower message, communication, and server computation complexities then existing T-PAKE's.