gebhart/patrepeval huggingface dataset:
Small-Signal Modeling and Speed Controller Design for Switched Reluctance Motor Drives (2018)

In this paper, the ac small signal modeling technique for both pulse-width-modulation (PWM) current and speed controller of SRM drive system is presented. With the small signal modeling for linearization of the SRM, the output transfer function in both PWM current loop and speed loop can be obtained. Both PI current controller and PI speed controller can be also designed with sufficient stability margin by using the small signal model. A criterion for selection of proportional and integral (PI) controller for an SRM is also proposed. In order to simultaneously reduce acoustic noise and torque ripple, a specific current profile was applied to SRM drives with proposed current and speed controller. A hardware prototype of 12/8, three-phase 2kW SRM with TMS320F28335 was constructed and tested. The criteria for selection of PI controller is applied to the SRM Drive system. Torque ripple and acoustic noise in both cases of traditional square current waveform and the modified current profile are compared. The experimental results indicate that the proposed method for derivation of optimized gains can lead to reduced acoustic noise and improve the dynamic performances of the SRM drive system.
REAL-TIME ENVIRONMENTAL INFORMATION NETWORK AND ANALYSIS SYSTEM: PHASE V STATUS REPORT (1997)

The Real-Time Environmental Information Network and Analysis System (REINAS) is a continuing engineering research and development program with the goal of designing, developing and testing an operational prototype system for data acquisition, data management, and visualization. This system is to support the real-time utilization of advanced instrumentation in environmental science. Current applications are in meteorology and oceanography; others envisioned include geophysics, hydrology, air pollution, etc. The REINAS project has been funded by a Department of Defense University Research Initiative through the Office of Naval Research. Participating institutions include the Naval Postgraduate School (NPS), the Monterey Bay Aquarium Research Institute (MBARI) and the Baskin Center for Computer Engineering and Information Sciences of the University of California, Santa Cruz (UCSC). The REINAS system has been designed for regional real-time environmental monitoring and analysis. It is a modern system, integrated into the Internet, for conducting interactive real-time coastal air/ocean science. The database design of REINAS is independent of specific database technology and is designed to support operational scientific needs throughput the entire scientific data life-cycle. During the previous phases a survey of available technologies was made, selections of the those to be used in the prototype system were made, and detailed architecture of REINAS and experimentation with subsystems for data collection, data management, processing, and visualization were started.
Data from Ultrasound Molecular Imaging in a Human CD276 Expression–Modulated Murine Ovarian Cancer Model (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; To develop a mouse ovarian cancer model that allows modulating the expression levels of human vascular targets in mouse xenograft tumors and to test whether expression of CD276 during tumor angiogenesis can be visualized by molecularly targeted ultrasound &lt;i&gt;in vivo&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; CD276-expressing MILE SVEN 1 (MS1) mouse endothelial cells were engineered and used for coinjection with 2008 human ovarian cancer cells for subcutaneous xenograft tumor induction in 15 nude mice. Fourteen control mice were injected with 2008 cells only. After confirming their binding specificity in flow chamber cell attachment studies, anti-CD276 antibody-functionalized contrast microbubbles were used for &lt;i&gt;in vivo&lt;/i&gt; CD276-targeted contrast-enhanced ultrasound imaging.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; CD276-targeted ultrasound imaging signal was significantly higher (&lt;i&gt;P&lt;/i&gt; = 0.006) in mixed MS1/2008 tumors than in control tumors. Compared with control microbubbles, the ultrasound signal using CD276-targeted microbubbles was significantly higher (&lt;i&gt;P&lt;/i&gt; = 0.002), and blocking with purified anti-CD276 antibody significantly decreased (&lt;i&gt;P&lt;/i&gt; = 0.0096) the signal in mixed MS1/2008 tumors. Immunofluorescence analysis of the tumor tissue confirmed higher quantitative immunofluorescence signal in mixed MS1/2008 tumors than in control 2008 only tumors, but showed not significantly different (&lt;i&gt;P&lt;/i&gt; = 0.54) microvessel density.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Our novel small animal model allows for modulating the expression of human tumor–associated vascular endothelial imaging targets in a mouse host and these expression differences can be visualized noninvasively by ultrasound molecular imaging. The animal model can be applied to other human vascular targets and may facilitate the preclinical development of new imaging probes such as microbubbles targeted at human vascular markers not expressed in mice. &lt;i&gt;Clin Cancer Res; 20(5); 1313–22. ©2014 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Supplementary Table 5 from Ganitumab (AMG 479) Inhibits IGF-II–Dependent Ovarian Cancer Growth and Potentiates Platinum-Based Chemotherapy (2023)

&lt;p&gt;PDF file - 53KB, IGF1R and INSR signaling in OV-90 and TOV-21G cell lines.&lt;/p&gt;
Transport Spectroscopy of Single Phosphorus Donors in a Silicon Nanoscale Transistor (2009)

This thesis demonstrates the fabrication and the measurement of single-electron tunnelling through deliberately implanted individual phosphorus (P) donors in double-gated silicon nanoscale field-effect-transistors (nanoFET). These structures conveniently allow the control of the number, depth, and tunnel coupling of the donors. For each P donor, three possible charge states have been observed, in which two are successively occupied by spin-down and spin-up electrons in a magnetic field. These states are separated by a charging energy consistent with those between the D0 and D− charge states of a P donor coupled to the surrounding electrodes. These experiments provide important understanding of the electric and magnetic properties of individual phosphorus donors needed for the realization of Si:P nanoelectronics. The demonstrated ability to resolve spin states of donors in these devices is the first step towards the measurement of electrically-detected magnetic resonance for a single-donor electron spin. Due to the tunability of the Fermi levels of the reservoirs of the nanoFET, the density of states (DOS) in the source and drain reservoirs are found to be quasi-1-dimensional. These reservoir DOS modulate the transport current through the nanoFET, consequently manifesting themselves as conductance peaks in bias stability diagrams. Further investigations showed that in a externally applied magnetic field, these DOS peaks shift in magnetic field at precisely half the Zeeman-splitting energy compared with peaks related to P-donor bound electrons, in good agreement with theoretical predictions. This result enables convenient discrimination between spin and orbital excited states from other features attributed to DOS modulations in the leads. Another important feature observed in the bias stability diagrams is the mutual charging effect of adjacent parallel donors in the conducting channel of the nanoFET. Charging a single donor in parallel with other active donors gives rise to a potential shift which is significant compared with the D0 and D− charging energy. In addition, the mutual charging energy also provides a good indication of the proximity of the active donors in the conducting channel. The successful demonstration of resonant tunnelling through locally-doped P donors in silicon in these nanoFET structures indicates that they can provide a convenient platform for the investigation of single-atom nanoelectronics and spintronics in silicon.
Determination Of The CD Dispersion And Proximity Bias Across The Lens Field By Electrical Linewidth Measurements (1998)

The two next transistors generations, 0 25μm and 0 18μm, are certainly going to be realized at 248nm In this conditions, the optical proximity effects (OPE) considerably reduce the process window The study and the characterization of such effect become critical, and Optical Proximity Correction (OPC) becomes an entire part of the photolithographic step.
Investigation of the potentialities of Vertical Resistive RAM (VRRAM) for neuromorphic applications (2015)

Combining Resistive RAM concept with Vertical NAND technology and design, Vertical RRAM (VRRAM) was recently proposed as a cost-effective and extensible technology for future mass data storage applications [1]. 3D RRAM based neural networks were also proposed to emulate the potentiation and depression of a synapse [2], but more complex circuits were not discussed. In previous works [3-4], various RRAM based neuromorphic circuits were proposed and investigated, using planar devices.
Dynamical behavior of spots in a nonequilibrium distributive active medium (1997)

Numerical studies of a two-dimensional active medium with long-range inhibition and additional global inhibition far from equilibrium, show a bifurcation sequence from stationary spots to elliptically oscillating spots, followed by a transition to traveling spots. General properties of the spot dynamics and their dependence on the applied boundary conditions, as well as on the global inhibition are discussed.
Phytosphingosine and Sphingosine Ceramide Headgroup Hydrogen Bonding:  Structural Insights through Thermotropic Hydrogen/Deuterium Exchange (2001)

IR spectroscopic studies are reported for the phytosphingosine class of ceramides and are compared with two analogous sphingosine ceramides. The phytosphingosine class of molecules, not previously widely investigated by physical techniques, constitutes ∼30% of the total ceramide content of the stratum corneum, the barrier to permeability in skin. The current measurements utilize temperature-controlled horizontal attenuated total reflectance spectroscopy of hydrated films to study H → D exchange in the polar regions of the molecules as well as chain conformational order and packing properties. Analysis of the methylene stretching and scissoring vibrations reveals that the chains of the two phytosphingosine derivatives (ceramides 3 and 7) are much more poorly packed at room temperature than their sphingosine counterparts (ceramides 2 and 5 respectively), despite having order → disorder transitions some 15−20 degrees higher. This unanticipated relative stability of the phytosphingosines is traced to enhanced headgroup H-bonding interactions manifest by lower Amide I and higher Amide II frequencies. Water penetration into the polar regions is monitored by the temperature dependence of the Amide II and O−H/N−H stretching intensities as a function of H→D exchange. Neither ceramide 2 nor 3 exchanges N−H or O−H protons until relatively high temperatures (>65 °C). However, addition of an α-hydroxy group on the fatty acid chain in ceramides 5 or 7 results in exchange events observed at temperatures much closer to physiological. These measurements reveal that the relative contributions of chain packing and H-bonding under physiological conditions differ markedly for the phytosphingosines compared to the sphingosines. The former are characterized by hexagonal chain packing with relatively strong H-bonding; the latter by orthorhombic chain packing and weaker H-bonding. The implications of these molecular structure data for lipid organization in the stratum corneum are briefly discussed.
Expression and Characterization of Murine Hevin (SC1), a Member of the SPARC Family of Matricellular Proteins (2004)

Hevin, also known as SC1, MAST 9, SPARC-like 1, RAGS1 and ECM2, is a member of the SPARC-related family of matricellular proteins. Mouse hevin is 53% identical to mouse SPARC, and both proteins share a follistatin-like module and an extracellular Ca(2+)-binding (E-C) domain. SPARC functions as a modulator of cell-matrix interactions, a regulator of growth factor activity, a de-adhesive protein, and a cell cycle inhibitor. Although the functions of mouse hevin are unknown, its human orthologue has been shown to be de-adhesive for endothelial cells. We now report the production of recombinant mouse hevin in insect cells through the use of a baculoviral expression system and its purification by anion-exchange, size-exclusion chromatography, and isoelectric focusing. Furthermore, we have produced rat anti-hevin monoclonal antibodies (MAbs) that have been characterized by indirect and capture ELISAs, immunoblotting, immunoprecipitation, and immunohistochemistry (IHC). Recombinant hevin, present as a soluble factor or bound to tissue-culture plastic, inhibited the spreading of bovine aortic endothelial cells in vitro. IHC analysis of hevin in normal human and mouse tissues revealed a limited expression pattern in many tissues, with particularly dominant staining in dermis, ducts, vasculature, muscle, and brain. In lung and pancreatic tumor xenografts, we found distinct reactivity with MAbs that were selective for stromal cells, tumor cells, and/or endothelial cells. Although similar to SPARC in its anti-adhesive activities, hevin nevertheless exhibits a distinctive histological distribution that, in certain invasive tumors, is associated with desmoplasia.
Glycothermal Synthesis and Characterization of YAG:Ce3+ Nanophosphors (2013)

Abstract not Available.
ChemInform Abstract: ON THE ABSOLUTE CONFIGURATION OF GEPHYROTOXIN (1982)

Abstract Die früher für Gephyrotoxin angegebene absolute Konfiguration (VIII) wird aufgrund röntgenspektroskopischer Untersuchungen im Sinne von (I) korrigiert.
Characterization of H5N1 Influenza Viruses That Continue To Circulate in Geese in Southeastern China (2002)

The H5N1 influenza virus, which killed humans and poultry in 1997, was a reassortant that possibly arose in one type of domestic poultry present in the live-poultry markets of Hong Kong. Given that all the precursors of H5N1/97 are still circulating in poultry in southern China, the reassortment event that generated H5N1 could be repeated. Because A/goose/Guangdong/1/96-like (H5N1; Go/Gd) viruses are the proposed donors of the hemagglutinin gene of the H5N1 virus, we investigated the continued circulation, host range, and transmissibility of Go/Gd-like viruses in poultry. The Go/Gd-like viruses caused weight loss and death in some mice inoculated with high virus doses. Transmission of Go/Gd-like H5N1 viruses to geese by contact with infected geese resulted in infection of all birds but limited signs of overt disease. In contrast, oral inoculation with high doses of Go/Gd-like viruses resulted in the deaths of up to 50% of infected geese. Transmission from infected geese to chickens occurred only by fecal contact, whereas transmission to quail occurred by either aerosol or fecal spread. This difference is probably explained by the higher susceptibility of quail to Go/Gd-like virus. The high degree of susceptibility of quail to Go/Gd (H5N1)-like viruses and the continued circulation of H6N1 and H9N2 viruses in quail support the hypothesis that quail were the host of origin of the H5N1/97 virus. The ease of transmission of Go/Gd (H5N1)-like viruses to land-based birds, especially quail, supports the wisdom of separating aquatic and land-based poultry in the markets in Hong Kong and the need for continued surveillance in the field and live-bird markets in which different types of poultry are in contact with one another.
Measurement of energy flow at large pseudorapidities in pp collisions at $ \sqrt {s} = 0.{9} $ and 7 TeV (2011)

The energy flow, dE/d, is studied at large pseudorapidities in proton-proton collisions at the LHC, for centre-of-mass energies of 0.9 and 7 TeV. The measurements are made using the CMS detector in the pseudorapidity range 3.15 < || < 4.9, for both minimum-bias events and events with at least two high-momentum jets. The data are compared to various pp Monte Carlo event generators whose theoretical models and input parameter values are sensitive to the energy-flow measurements. Inclusion of multipleparton interactions in the Monte Carlo event generators is found to improve the description of the energy-flow measurements.
Modular Approach to the Accelerated Convergent Growth of Laser Dye-Labeled Poly(aryl ether) Dendrimers Using a Novel Hypermonomer (1999)

The synthesis of novel dendrimers functionalized with laser dyes both at the periphery and at the core, along with all relevant model compounds necessary for accurate photophysical studies, is described. The utilized synthetic strategy involves a modular approach in which a variety of peripheral and core moieties can be placed on a dendritic structure bearing electrophilic peripheral groups and a nucleophilic core. Specifically, the target macromolecules required functionalization with the laser dyes coumarin 2 (periphery) and coumarin 343 (core) due to the possibility of energy transfer from the former to the latter dye. In addition, the preparation of a novel, highly soluble and reactive hypermonomer utilized in the rapid and efficient synthesis of high-generation dye-labeled dendrimers and model compounds is outlined.
Estimating the Soundscape Structure and Dynamics of Forest Bird Vocalizations in an Azimuth-Elevation Space Using a Microphone Array (2023)

Songbirds are one of the study targets for both bioacoustic and ecoacoustic research. In this paper, we discuss the applicability of robot audition techniques to understand the dynamics of forest bird vocalizations in a soundscape measured in azimuth and elevation angles with a single 16-channel microphone array, using HARK and HARKBird. First, we evaluated the accuracy in estimating the azimuth and elevation angles of bird vocalizations replayed from a loudspeaker on a tree, 6.55 m above the height of the array, from different horizontal distances in a forest. The results showed that the localization error of azimuth and elevation angle was equal to or less than 5 degrees and 15 degrees, respectively, in most of cases when the horizontal distance from the array was equal to or less than 35 m. We then conducted a field observation of vocalizations to monitor birds in a forest. The results showed that the system can successfully detect how birds use the soundscape horizontally and vertically. This can contribute to bioacoustic and ecoacoustic research, including behavioral observations and study of biodiversity.
Novel aprotic polar solvents for facile Baylis-Hillman reaction (2004)

Novel aprotic polar solvents are selected for use towards a facile Baylis-Hillman reaction catalyzed by the standard base (DABCO) at room temperature so that less reactive aldehydes and a broad spectrum of activated olefins (including acrylamide) could be coupled under the altered reaction conditions.
ROMK1 channel activity is regulated by monoubiquitination (2005)

The ubiquitination of proteins can signal their degradation, modify their activity or target them to specific membranes or cellular organelles. Here, we show that monoubiquitination regulates the plasma membrane abundance and function of the potassium channel, ROMK. Immunoprecipitation of proteins obtained from renal cortex and outer medulla with ROMK antibody revealed that this channel was monoubiquitinated. To determine the ubiquitin binding site on ROMK1, all intracellular lysine (Lys) residues of ROMK1 were individually mutated to arginine (Arg), and a two-electrode voltage clamp was used to measure the ROMK1 channel activity in Xenopus oocytes. ROMK1 channel activity increased from 8.1 to 27.2 microA only when Lys-22 was mutated to Arg. Furthermore, Western blotting failed to detect the ubiquitinated ROMK1 in oocytes injected with R1K22R. Patch-clamp experiments showed that biophysical properties of R1K22R were identical to those of wild-type ROMK1. Although total protein expression levels of GFP-ROMK1 and GFP-R1K22R in oocytes were similar, confocal microscopy showed that the surface fluorescence intensity in oocytes injected with GFP-R1K22R was higher than that of GFP-ROMK1. In addition, biotin labeling of ROMK1 and R1K22R proteins expressed in HEK293 cells showed increased surface expression of the Lys-22 mutant channel. Finally, expression of R1K22R in COS7 cells significantly stimulated the surface expression of ROMK1. We conclude that ROMK1 can be monoubiquitinated and that Lys-22 is an ubiquitin-binding site. Thus, monoubiquitination of ROMK1 regulates channel activity by reducing the surface expression of channel protein. This finding implicates the linking of a single ubiquitin molecule to channels as an important posttranslational regulatory signal.
[Use of DNA analysis in the diagnosis and prevention of hemophilia A]. (1990)

Hemophilia A belongs to the monogenically determined diseases. The methods of molecular genetics (recombinant DNA) have greatly contributed both to the elucidation of the genetic basis of these diseases and to the elaboration of effective preventive approaches either by prenatal genetic diagnosis or by detection of heterozygous transmitters. The authors present a short survey of the results in the field of genetic research of hemophilia A at molecular level achieved over the last years and they report on their own results of DNA analysis in 15 families with the occurrence of the disease. Of 17 potential subjects transmission was excluded in 10 and confirmed in 7 cases. The importance of early and complete detection of families with the occurrence of hemophilia A is emphasized particularly in the light of effective prevention.
A 90nm 512mb 166MHz multilevel cell flash memory with 1.5MByte/s programming (2005)

A 2b/cell flash memory in 90 nm triple-well CMOS technology achieves 1.5 MB/s programming and 166 MHz synchronous operation. The design features 2-row programming, optimized program control hardware, 3 transistor x-decoder with negative deselected rows and configurable output buffers. The die is 42.5 mm/sup 2/ with a cell size of 0.076 /spl mu/m/sup 2/.
A −236.3dB FoM sub-sampling low-jitter supply-robust ring-oscillator PLL for clocking applications with feed-forward noise-cancellation (2018)

A 2-2.8GHz 65nm CMOS ring oscillator PLL occupies an active area of 0.022mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , consumes 5.86mW and achieves a 633fs RMS jitter at 2.36 GHz and an FOM <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">jitter</sub> of -236.3dB. It implements a low-overhead feed-forward phase and supply-noise cancellation scheme by leveraging the noise extraction inherently done by the sub-sampling phase detector. Cancellation reduces the jitter by 1.4x, the phase noise by 10.2dB to -123.5dBc/Hz at a 300KHz offset, and the ring oscillator supply sensitivity by 19.5dB for a 1mV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">p-p</sub> 100KHz supply noise tone.
Palladium-Catalyzed Cross-Coupling Reactions of Bromo-Substituted Group 4 Metallocenes (2009)

Pd-catalyzed Negishi reactions of Zr and Hf complexes bearing η5-4-bromo-2-methylindenyl and η5-2-bromoindenyl ligands with MeZnCl and various aryl- and heteroarylzinc reagents (RZnCl) give in high yields the respective complexes bearing η5-4-R-2-methylindenyl and η5-2-R-indenyl ligands, respectively.