gebhart/patrepeval huggingface dataset:
Synthesis and Reactions of 3-(Bromomethyl)-1-carbethoxy-4-iodoindole: The Preparation of 3,4-Differentially Substituted Indoles (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Reactions of 3-(Bromomethyl)-1-carbethoxy-4-iodoindole: The Preparation of 3,4-Differentially Substituted IndolesJeffrey H. Tidwell, Andrew J. Peat, and Stephen L. BuchwaldCite this: J. Org. Chem. 1994, 59, 23, 7164–7168Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://pubs.acs.org/doi/10.1021/jo00102a055https://doi.org/10.1021/jo00102a055research-articleACS PublicationsRequest reuse permissionsArticle Views1005Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Coherent population trapping in diamond N-V centers at zero magnetic field (2006)

All-optical coherent population trapping is possible in nitrogen-vacancy centers in diamond at zero magnetic field. This should allow for simpler implementations of potential devices involving optical manipulation of electron spins.
New Antithrombotics with an Indazole Structure (2004)

Fifteen new indazole derivatives have been synthesized. In the Born test, compounds (4f) and (4g) were most active. They inhibited the blood platelet aggregation induced by collagen with an IC(50) = 85 or 90 microM, respectively. After oral administration to rats (60 mg/kg) three of the compounds significantly inhibited the formation of thrombi in arterioles and venules. The strongest effect was observed with (4j) which showed an inhibition of 15% in arterioles and 7% in venules. Further experiments showed that compound (4j) does not mediate these effects by activating soluble guanylate cyclase, but likely by inhibiting phosphodiesterase isoform PDE 5.
Kinetic parameters of thermal degradation of polyethylene glycol-toughened novolac-type phenolic resin (2001)

The miscibility and thermal degradation of poly(ethylene glycol) (PEG)-toughened novolac-type phenolic resin were investigated. Differential scanning calorimetry (DSC) results confirmed that the phenolic resin/PEG blend was blended completely. Infrared spectra show that hydrogen bonding existed in the blends. Thermal degradation of PEG blended with novolac-type phenolic resin was studied utilizing a dynamic thermogravimetric technique in a flowing nitrogen atmosphere at several heating rates (i.e., 5, 10, 20, 40°C/min). Thermal degradation of phenolic resin/PEG blends takes place in multiple steps. The thermal behavior and the thermal stability affected the thermal degradation, which coincided with the data from the thermal degradation of novolac-type phenolic resin/PEG blends by thermogravimetric analysis (TGA). © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 80: 188–196, 2001
Corpus and Annotation Towards NLU for Customer Ordering Dialogs (2018)

Ordering products and services through virtual agents is possible but suffers limitations on the kind of ordering that is possible or on the naturalness of the conversation. We address these limitations by collecting a corpus of human-human dialogs in the food ordering domain. We create a food focused annotation scheme that is tailored for this corpus but customizable for other applications. After annotating the corpus, we find corpus characteristics that may make it more natural, such as complexity of food item mentions and use of multiple intent utterances. Furthermore, we train and evaluate preliminary statistical item and intent models using the annotated corpus.
SU-E-T-532: An Improved Deterministic 3D Dose Calculation for Radiation Therapy Application (2013)

PurposeHere we present a Hybrid Deterministic-Monte Carlo dose calculation algorithm, EDK-Sn, in a parallel computation environment, for rapid whole body dose calculation. This method adapts the Varian Clinac head model. Method and Materials Current treatment planning dose calculation algorithm poses two major challenges: inhomogeneity correction for small field and out-of-field secondary organ dose calculation inaccuracy. Currently, full physics Monte Carlo calculations have been regarded as a ‘gold standard’ for dose assessment of in field inhomogeneity correction and out of field Organ at Risk assessment. However, traditional Monte Carlo calculations require very long computation times, and also demonstrate large statistical errors for out-of-field dose. Deterministic transport dose calculation resolves the above issues without statistical inaccuracies; one example is the AcurosXB dose calculation engine adapted by Varian medical systems. We developed a hybrid deterministic-Monte Carlo 3D dose calculation for 3D whole body organ dose calculation. The Varian Clinac iX Linear Accelerator at Georgia Tech has been modeled from IAEA phase space into deterministic dose transport modeling, and performed calculations with the Linear Boltzmann equation in discrete ordinates (Sn) system using PENTRAN deterministic dose solver to obtain 3D photon fluence in the 3D space with 16 discrete energy bins, 4000 angles and in 3D space for whole body phantom organ dose. We then apply a quaternion rotation based on pre-calculated MCNP electron dose kernels that have been calculated in a high performance computing environment to obtain organ doses. Results This deterministic transport calculation method has been validated to be faster than full Monte Carlo, with comparable accuracy and differences under 10% for different organ dose calculations. The hybrid transport method for accessing organ doses also demonstrated minimized statistical errors. Conclusion Our hybrid EDK-Sn method has been validated for assessing organ doses for radiotherapy.
Figure S2 from A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy (2023)

&lt;p&gt;Supplementary Figure 2: Modest treatment-induced DNA methylation changes in UC tumors.&lt;/p&gt;
Design of a Biologically Accurate Prosthetic Hand (2017)

A high fidelity biomimetic hand actuated by 9 stepper motors packaged within forearm casing was manufactured for less than 350 USD; it has 18 mechanical degrees of freedom, is 38 cm long, weighs 2.2 kg. The hand model has 3D printed replicas of human bones and laser cut tendons and ligaments. The user intent is deduced from EEG and EMG signals, obtained by Neurosky and Myoware commercial sensors, respectively. Three distinct EEG patterns trigger pinch, hook, and point actions. EMG signals are used for finer motor control, e.g. strength of grip. A pilot test study on three subjects showed that EMG can actuate the hand with an 80% success rate, while EEG allows for a 68% success rate. The system proved its robustness at the 2017 Cambridge Science Festival, using EEG signals alone. Out of approximately 30 visitors the majority could generate a “peace” sign after 1 to 2 minutes.
A Prospective, Randomized, Controlled Clinical Investigation Comparing PCM Cervical Disc Arthroplasty With Anterior Cervical Discectomy and Fusion (2013)

The treatment of symptomatic single-level cervical spondylosis with PCM achieves clinical outcomes that are at least equivalent to ACDF while maintaining motion. At 2 years, patients with PCM had lower NDI scores, statistically lower rate of prolonged dysphagia, greater patient satisfaction, and superior overall success.
Carrots and Dietary Vitamin A Adequacy (1992)

Carrots are a leading source e of vitamin A in the Guatemalan diet. Analyses of carrots using high performance liquid chromatography (HPLC’) indicated that carrots have more than twice the amount of β carotene reported in the Latin American food compositio n tables. The consequence for the recalculation of daily vitamin A intake in a data set of pregnant pert-urban women is a 12% reduction in the number of women consuming &lt;750 RE and a 19% reduction in the number with an intake of &lt;600 RE. To the extent that earlier anayses underestimated the β carotene content of’ carrots, the estimates of vitamin A intake in Latin America have been variably and falsely low, depending on the contribution of carrots to the individuals reported diet.
Toward Calenderability of High‐Energy Cathode based on NMC622 during the Roll‐to‐Roll Process (2023)

For the economical production of high‐quality lithium‐ion batteries, a comprehensive understanding of all processing steps under real production conditions, especially in the electrode‐manufacturing step, is mandatory. It has been shown that calendering of the cathode has a significant impact on the electrode quality and hence affects their subsequent processability in the battery production. Undesirable electrode deformation induced by the calendering process may lead to unnecessary wastage during the roll‐to‐roll process. To increase the yield rate of high‐energy electrode production under industrial‐oriented conditions, an extensive recipe evaluation by applying mixture design methods has been carried out on the lab scale. It has been shown that the inactive carbon black/PVDF phase as well as the amount of SFG6L in the electrode formulation plays an important role in the calendering processability of the high‐energy NMC622 cathode. From the statistical data analysis, an optimized recipe has been proposed and afterward validated at the research production line under industry‐relevant conditions. A significant reduction of the scrap rate caused by the calendering process is observed after optimizing the recipe due to its better calenderability.
Présentation d’Edith Heard (2013)

Chère Edith Heard, Il n’y a pas grand-chose à ajouter à l’enregistrement de Serge Haroche qui m’a demandé de le remplacer alors qu’il est retenu à Stockholm... Je me contenterai de rappeler qu’ayant défendu une thèse en cancérologie à Londres, vous avez traversé la Manche en 1990 pour venir travailler à l’Institut Pasteur sous la direction de Philip Avner. Dix ans plus tard, après un court séjour sabbatique à Cold Spring Harbor, vous rejoignez l’Institut Curie comme récipiendaire d’un contra...
Navigating through the Frame Problem: Review of Reasoning Agents in a Dynamic World (1994)

A review of Reasoning Agents in a Dynamic World: The Frame Problem, Kenneth M. Ford and Pat Hayes, eds., JAI Press, Greenwich, Connecticut, 1991, 289 pp., $68.50, ISBN 1-55938-082-9.
Non-intrusive scalable memory access tracer (2014)

Memory access tracing is one of the widely used methods to evaluate, analyze, and optimize hardware and software designs. We are developing a non-intrusive, scalable, full-address-range memory tracer. The tracer hardware board is compliant with the JEDEC DDR3 DIMM form factor, and fits in a DIMM slot. It is so compact that we can populate up to 16 tracer boards in a 4-CPU server chassis, and record the commands and addresses of all the memory accesses. Each board drives four SSDs to record the memory access addresses without a break until the SSDs are full. For example, we can make a trace of a full SPECjbb 2005 run, which lasts 26 minutes and generates over 11TB trace data. In addition to recording memory accesses, it collects various types of statistical data, such as a large number of segmented read/write statistics and DRAM bank utilization rates, and displays them on the control dashboard in real time.
5–10 Gb/s 70 mW Burst Mode AC Coupled Receiver in 90-nm CMOS (2010)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> A low power burst mode receiver architecture is presented which can be used for AC coupled links where low frequency signal components are attenuated by the channel. The nonlinear path comprises a hysteresis latch that recovers the missing low frequency content and a linear path that boosts the high frequency component by taking advantage of the high pass channel response. By optimally combining them, the front-end recovers NRZ signals up to 13 Gb/s burning only 26 mW in 90 nm CMOS. A low power- and area-efficient clock recovery scheme uses the linear path to injection lock an oscillator. A simple theory and simulation technique for ILO-based receivers is discussed. The clock recovery technique is verified with experimental results at 5–10 Gb/s in 90 nm CMOS consuming 70 mW and acquiring lock within 1.5 ns. </para>
Fiber laser probe for near-field scanning optical microscopy (1993)

A hybrid near-field/fiber laser probe has been developed for high flux, reflection mode optical imaging of surfaces on a subwavelength scale. Spatial resolution of ∼100 nm (i.e., ∼λ/10 at λ=1060 nm) has been achieved simultaneously with signals of ∼1014–1015 photons/s, an improvement of ∼103–104 over earlier designs. The probe thus represents an important step in the development of advanced near-field transducers for high bandwidth applications such as high density data storage.
Noise Robust Voice UI Technology and Its Applications (2013)

This paper introduces a technology of noise-robust speech recognition to correctly recognize a user’s speech even in places with a high level of background noise and immediately respond to it, together with applications of this technology. Voice UI is useful when the user’s hands or eyes are busy, but the background noise may cause false operations. The accurate detection of the user’s speech using two microphones and the noise reduction with speech patterns suitable for speech recognition; these techniques enable applications of speech recognition in domains where this has previously been regarded as being difficult. In addition, these techniques also enable the usage of voice UI more natural.
[Development of nanomedicine using intracellular DDS]. (2006)

In recent years, sustained release and targeting system using nanospheres or microspheres is noticed in systemic pharmacokinetics. However, in the near future, not only "systemic pharmacokinetics" but also "intracellular pharmacokinetics" seems to be important in Drug Delivery System research. In this context, we have tried to develop the novel cytoplasmic nanoparticle (NP) delivery methods using fusogenic liposomes (FL) and protein transduction domain (PTD). In this study, we demonstrated that the FL efficiently delivered the encapsulated NP to the cytoplasm directly in a fusion -dependent. Oligonucleotides attached to NP were gradually released in the cytoplasm after its efficient delivery using FL. Furthermore, we have succeeded in identifying the novel PTD using phage displayed random peptide library. In near future, this novel PTDs are applied to cytoplasmic NP delivery carrier. From these results, we suggested that this technology is very important to control the intracellular pharmacokinetics, and can be also applied to any NP which will be produced by the nanotechnology in the future.
Deep Brain Stimulation Alleviates Parkinsonian Bradykinesia by Regularizing Pallidal Activity (2010)

Deep brain stimulation (DBS) of the basal ganglia can alleviate the motor symptoms of Parkinson's disease although the therapeutic mechanisms are unclear. We hypothesize that DBS relieves symptoms by minimizing pathologically disordered neuronal activity in the basal ganglia. In human participants with parkinsonism and clinically effective deep brain leads, regular (i.e., periodic) high-frequency stimulation was replaced with irregular (i.e., aperiodic) stimulation at the same mean frequency (130 Hz). Bradykinesia, a symptomatic slowness of movement, was quantified via an objective finger tapping protocol in the absence and presence of regular and irregular DBS. Regular DBS relieved bradykinesia more effectively than irregular DBS. A computational model of the relevant neural structures revealed that output from the globus pallidus internus was more disordered and thalamic neurons made more transmission errors in the parkinsonian condition compared with the healthy condition. Clinically therapeutic, regular DBS reduced firing pattern disorder in the computational basal ganglia and minimized model thalamic transmission errors, consistent with symptom alleviation by clinical DBS. However, nontherapeutic, irregular DBS neither reduced disorder in the computational basal ganglia nor lowered model thalamic transmission errors. Thus we show that clinically useful DBS alleviates motor symptoms by regularizing basal ganglia activity and thereby improving thalamic relay fidelity. This work demonstrates that high-frequency stimulation alone is insufficient to alleviate motor symptoms: DBS must be highly regular. Descriptive models of pathophysiology that ignore the fine temporal resolution of neuronal spiking in favor of average neural activity cannot explain the mechanisms of DBS-induced symptom alleviation.
Dataset of experimental measurements for "Demonstration of quantum advantage in machine learning" (2017)

Dataset of experimental measurements for "Demonstration of quantum advantage in machine learning", npj Quantum Information 3, Article number: 16 (2017).
HD ( v = 1, j = 2, m ) orientation controls HD–He rotationally inelastic scattering near 1 K (2019)

To investigate how molecular orientations affect low energy scattering, we have studied the rotational relaxation of HD (v = 1, j = 2, m) → (v' = 1, j' = 0) by collision with ground-state He, where v, j, and m designate the vibrational, rotational, and magnetic quantum numbers, respectively. We experimentally probed different collision geometries by preparing three specific m sublevels, including an m entangled sublevel, belonging to a single rovibrational (v = 1, j = 2) energy level within the ground electronic state of HD using Stark-induced adiabatic Raman passage. Low collision energies (0-5 K) were achieved by coexpanding a 1:19 HD:He mixture in a highly collimated supersonic beam, which has defined the direction of the collision velocity and restricted the incoming orbital angular momentum states, defined by the quantum number l, to l ≤ 2. Partial wave analysis of experimental data shows that a single l = 2 input orbital dominates the scattered angular distribution, implying the presence of a collisional resonance. The differential scattering angular distribution exhibits a greater than fourfold stereodynamic preference for the m = 0 input state vs m = ±2, when the quantization axis is oriented parallel to the collision velocity.
A planar-reflective symmetry transform for 3D shapes (2006)

Symmetry is an important cue for many applications, including object alignment, recognition, and segmentation. In this paper, we describe a planar reflective symmetry transform (PRST) that captures a continuous measure of the reflectional symmetry of a shape with respect to all possible planes. This transform combines and extends previous work that has focused on global symmetries with respect to the center of mass in 3D meshes and local symmetries with respect to points in 2D images. We provide an efficient Monte Carlo sampling algorithm for computing the transform for surfaces and show that it is stable under common transformations. We also provide an iterative refinement algorithm to find local maxima of the transform precisely. We use the transform to define two new geometric properties, center of symmetry and principal symmetry axes, and show that they are useful for aligning objects in a canonical coordinate system. Finally, we demonstrate that the symmetry transform is useful for several applications in computer graphics, including shape matching, segmentation of meshes into parts, and automatic viewpoint selection.
ChemInform Abstract: Direct Synthesis of Polyfused Ring Systems by Intramolecular Tandem Palladium‐Ene/Heck Insertion Reactions. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The compressive multiplexer for multi-channel compressive sensing (2011)

The recently developed compressive sensing (CS) framework enables the design of sub-Nyquist analog-to-digital converters. Several architectures have been proposed for the acquisition of sparse signals in large swaths of bandwidth. In this paper we consider a more flexible multi-channel signal model consisting of several discontiguous channels where the occupancy of the combined bandwidth of the channels is sparse. We introduce a new compressive acquisition architecture, the compressive multiplexer (CMUX), to sample such signals. We demonstrate that our architecture is CS-feasible and suggest a simple implementation with numerous practical advantages.
Editorial Commentary: With New Technology Comes New Responsibility: Do the Complications of Hip Arthroscopy See Us More Often Than We See Them? (2017)

A database study of the codes for hip arthroscopy reports a rate of major and minor complications that is higher than previously reported in the literature. The relative risk of conversion to hip replacement or a subsequent fracture or dislocation is greater than in the general population.
In silico Design of Supramolecules from Their Precursors: Odd–Even Effects in Cage-Forming Reactions (2013)

We synthesize a series of imine cage molecules where increasing the chain length of the alkanediamine precursor results in an odd-even alternation between [2 + 3] and [4 + 6] cage macrocycles. A computational procedure is developed to predict the thermodynamically preferred product and the lowest energy conformer, hence rationalizing the observed alternation and the 3D cage structures, based on knowledge of the precursors alone.
Lithography performance and environmental compatibility of PFOS-free photoacid generators (2017)

Photoacid generators (PAGs) with environmentally friendly cores and partially fluorinated sulfonate salts have been synthesized and studied. The cores were based on naturally occurring compounds such as cholesterol and glucose and were functionalized with a biodegradable octafluoro-3-oxapentanesulfonate. These PAGs were soluble in common spinning solvents and lithographically characterized with poly(styrene-co-4-hydroxy-styrene-co-tert-butylacetate) photoresist, and they showed higher resolution for photoresist applications than a perfluorooctane sulfonate (PFOS)-based triphenylsulfonium salt PAG, capable of patterning 50 nm dense lines. In addition, microbial bioassays confirmed that the newly developed PAG compounds can be broken down by microorganisms commonly found in conventional wastewater treatment systems. The biodegradation potential of the new PAGs presents a distinct advantage compared to that of PAG perfluorinated structures such as PFOS and perfluorobutane sulfonate, which are highly resistant to biodegradation and difficult to treat by conventional processes. The excellent performance and environmental compatibility of these PAGs make them promising candidates for use in high-resolution lithography systems.
Nanoplasmonic sensing (NPS) combined with electrochemical and QCM-D sensing for corrosion studies (2011)

After thermo-chemotherapy, the expression of LTI, IL-2 and TNF-alpha of tumor-bearing hosts are significantly improved, there is a significant correlation between IL-2 and T cell.