gebhart/patrepeval huggingface dataset:
Multicomponent gas sorption in glassy polymers (1985)

Abstract Glassy polymers are nonequilibrium solids whose properties may change slowly due to time‐dependent variation in the excess volume and enthalpy functions of these materials. Measurable changes in the gas sorption behavior of samples exposed to different time–temperature histories below the polymer's glass transition temperature can be explained primarily in terms of differences between the excess volume of different samples. A simple physical and mathematical model will be described which relates excess sorption in glasses, compared to rubbery polymers, to sorption into excess volume frozen into the quenched matrix. The model will be explained for pure component gases and then generalized to treat multicomponent sorption data for the CO 2 /C 2 H 4 and CO 2 /N 2 O systems in poly(methyl methacrylate). The rather complex mixed gas behavior can be predicted quantitatively using only pure component sorption data in conjunction with the generalized model for multicomponent gases. The model, based on the concept of competition of sorbing penetrants for the excess volume present in the glass, is successful for the two systems described above for total pressures up to 300 psia.
A Verilog piecewise-linear analog behavior model for mixed-signal validation (2013)

Full chip mixed-signal validation requires simulating the entire design through a large number of test vectors, which makes fast, event-based Verilog models of analog circuits essential. We describe an extensible approach to creating these models that maps continuous signals into piecewise linear waveforms by creating analog events which contain a value and slope. By breaking analog circuits into sub-blocks with mostly unidirectional ports, we avoid explicit time integration, thus fitting well into an event-driven digital framework. The result is Verilog analog functional models that are pin-accurate, fast to simulate and capture the key dynamics in analog circuits. A 2.5V-1.8V buck converter and 1GHz PLL models are demonstrated.
Antenna selection for time-varying channels based on slepian subspace projections (2012)

Single receive antenna selection (AS) allows single-input single-output (SISO) systems to retain the diversity benefits of multiple antennas with minimum hardware costs. We propose a single receive AS method for time-varying channels, in which practical limitations imposed by next-generation wireless standards such as training, packetization and antenna switching time are taken into account. The proposed method utilizes low-complexity subspace projection techniques spanned by discrete prolate spheroidal (DPS) sequences. It only uses Doppler bandwidth knowledge, and does not need detailed correlation knowledge. Results show that the proposed AS method outperforms ideal conventional SISO systems with perfect CSI but no AS at the receiver and AS using the conventional Fourier estimation/prediction method. A closed-form expression for the symbol error probability (SEP) of phase-shift keying (MPSK) with symbol-by-symbol receive AS is derived.
Distortion matrix concept for deep imaging in optical microscopy (2020)

In optical imaging, light propagation is affected by the medium inhomogeneities. Adaptive optics has been employed to compensate for sample-induced aberrations but the field-of-view is often limited to a single isoplanatic patch. Here, we propose a non-invasive approach based on the distortion matrix concept. This matrix basically connects any focusing point with the distorted part of its wave-front in reflection. Its time- reversal and entropy analysis allows to correct for high-order aberrations over multiple isoplanatic areas. We demonstrate a Strehl ratio enhancement up to 2500 and a diffraction- limited resolution until a depth of ten scattering mean free paths through an opaque cornea.
Supramolecular Copolymerization as a Strategy to Control the Stability of Self‐Assembled Nanofibers (2018)

A major challenge in supramolecular polymerization is controlling the stability of the polymers formed, that is, controlling the rate of monomer exchange in the equilibrium between monomer and polymer. The exchange dynamics of supramolecular polymers based on benzene-1,3,5-tricarboxamide (BTA) can be regulated by copolymerizing molecules with dendronized (dBTA) and linear (nBTA) ethylene glycol-based water-soluble side chains. Whereas nBTAs form long nanofibers in water, dBTAs do not polymerize, forming instead small spherical aggregates. The copolymerization of the two BTAs results in long nanofibers. The exchange dynamics of both the BTA monomers in the copolymer are significantly slowed down in the mixed systems, leading to a more stable copolymer, while the morphology and spectroscopic signature of the copolymers are identical to that of nBTA homopolymer. This copolymerization is the supramolecular counterpart of styrene/ maleic anhydride copolymerization.
Superparamagnetic iron oxide nanoparticles functionalized by peptide nucleic acids (2017)

Hydrophilic SPION were decorated with PNA decamers by SH/maleimide clickreaction as potential MRI and hyperthermia agents, and PNA carriers.
Development of a Large Scale Production Process for BAX 855, a PEGylated rFVIII Product with Prolonged Half-Life (2011)

Abstract Abstract 4362 Baxter and Nektar have developed BAX 855, a PEGylated form of Baxter’s recombinant FVIII (rFVIII) product based on the ADVATE™ manufacturing process. The conjugation process for preparing BAX 855 uses proprietary stable PEGylation from Nektar Therapeutics. Similar Nektar technology has been successfully employed for marked and licensed PEGylated drug products and drugs in clinical use. The manufacturing process for BAX 855 comprises several steps, including chromatographic purification on a MacroCap SP resin, a strong cation exchanger, which allows the fractionation of species with different PEGylation degrees and concentration of the conjugate collected by an ultra- / diafiltration step leading to the pre-formulated bulk drug substance (BDS). Final formulation of the BDS includes a filling and lyophilization step to obtain the final drug product. The process described is suited to manufacture BAX 855 in gram scale and showed a good batch to batch consistency, ensuring an equivalent product quality for each batch. BAX 855 manufactured by this process has a specific activity similar to that of rFVIII in ADVATE™ and PEGylation degrees in the narrow range of 2 to 3 mols PEG / mol rFVIII. SDS-PAGE and Western blot analysis of BAX 855 confirm the stable PEGylation and demonstrate an increase in the molecular weight of the various FVIII domains. PK studies in different species display longer survival of BAX 855 compared to ADVATE™. Disclosures: Siekmann: Baxter Innovations GmbH: Employment. Martin:Baxter Innovations GmbH: Employment. Zöchling:Baxter Innovations GmbH: Employment. Kellerer:Baxter Innovations GmbH: Employment. Rottensteiner:Baxter Innovations GmbH: Employment. Mitterer:Baxter Innovations GmbH: Employment. Bossard:Nektar Therapeutics: Employment. Phillips:Nektar Therapeutics: Employment. Ehrlich:Baxter Innovations GmbH: Employment. Scheiflinger:Baxter Innovations GmbH: Employment. Turecek:Baxter Innovations GmbH: Employment.
Protons Activate Brain Na+ Channel 1 by Inducing a Conformational Change That Exposes a Residue Associated with Neurodegeneration (1998)

BNC1 is a mammalian neuronal cation channel in the novel DEG/ENaC ion channel family. BNC1 channels are transiently activated by extracellular protons and are constitutively activated by insertion of large residues, such as valine, in place of Gly-430; residue 430 is a site where analogous mutations in some Caenorhabditis elegans family members cause a swelling neurodegeneration. Mutation of Gly-430 to a small amino acid, cysteine, neither generated constitutive currents nor allowed modification of this residue by sulfhydryl-reactive methanethiosulfonate (MTS) compounds. However, when protons activated the channel, Cys-430 became accessible to extracellular MTS reagents, which modified Cys-430 to generate constitutive currents. Fluorescent MTS reagents also labeled Cys-430 in activated channels. These data indicate that protons induce a reversible conformational change that activates BNC1 thereby exposing residue 430 to the extracellular solution. Once Cys-430 is modified with a large chemical group, the channel is prevented from relaxing back to the inactive state. These results link ligand-dependent activation and activation by mutations that cause neurodegeneration.
Stochastic Model on the Post-Fabrication Error for a Bragg Reflectors Based Photonic Allpass Filter (2011)

This paper presents an analysis of the post fabrication performance for a Bragg-mirrors-based photonic allpass filter. The development subsequently leads to a first definition of the stochastic measures in a realistic system implementation. A Digital Signal Processing (DSP) approach to examining photonic integrated circuitry is explored in depth. The physical origins of error that manifests in an unbalanced phase error is mathematically described in detail. We describe the details of error analysis and demonstrate a stochastic measure for the expected behavior of first-order allpass filter as well as high complexity systems. Our findings show that the frequency performance under error can be characterized by a convolution of the ideal response with a probability function based kernel.
Crystallization in InGaAs/InP Heterostructures with a Strong Disorder (1995)

Non-linear current-voltage characteristics were observed in the range of filling factors of 0.3 < v < 0.4 in a two-dimensional electron system in InGaAs/InP heterostructures with a strong disorder. The observations are explained qualitatively in terms of magnetic field induced localization and Wigner solidification.
VAV1 Activating Mutations and Translocations in Peripheral T-Cell Lymphomas (2016)

Abstract Peripheral T-cell lymphomas (PTCL) are malignant and highly aggressive hematologic tumors arising from mature post thymic T-cells. The diagnosis of PTCL includes diverse lymphoma subgroups, altogether accounting for about 15% of all non-Hodgkin lymphomas. Despite much effort in developing reliable diagnostic markers, the diagnosis of PTCLs is challenging and 20-30% of cases are diagnosed as PTCL-NOS (not otherwise specified). This heterogeneous and poorly defined group of lymphomas is frequently characterized by chemotherapy resistance and a very poor prognosis. Here we report the presence of recurrent driver activating genetic alterations in the VAV1 gene in PTCL, NOS. RNA-seq analysis of a comprehensive series of 154 PTCLs and targeted sequencing identified VAV1 gene fusions with different partners including VAV1-THAP4, VAV1-MYO1F and VAV1-S100A7. In all cases the resulting oncoproteins lack the C-terminal SH3 domain of VAV1, a motif implicated in the negative regulation of VAV1 signaling, leading to increased activation of VAV1 catalytic-dependent (MAPK, JNK) and non-catalytic-dependent (NFAT) VAV1 effector pathways. In addition, and most notably, we also identified focal microdeletions at the VAV1 intron 25-exon 26 boundary, which result in the activation of an alternative intraexonic splice acceptor site and the consequent expression of mis-splicing-driven mutant transcripts harboring a recurrent VAV1 Δ778-786 in-frame deletion. Mechanistically, the VAV1 Δ778-786 mutation removes 9 amino acids proximal to the C-terminal VAV1 SH3 domain and induces in increased VAV1 activation and signaling in biochemical assays. In all, these results support a driver role for oncogenic VAV1 signaling in T-cell transformation of major importance for the design of targeted therapies for the treatment of PTCL, NOS. Disclosures No relevant conflicts of interest to declare.
194. Characteristics of Site-Specific Integration as Mediated by PhiC31 Integrase in the Human Genome (2005)

The phiC31 integrase is a site-specific recombinase originally isolated from a Streptomyces bacteriophage. It has been shown by our lab to perform a recombination reaction in mammalian cells that can result in the efficient chromosomal integration of plasmid DNA and long-term transgene expression. Such naked DNA vectors have a wide range of possible uses, including many gene therapy applications. Traditional plasmid vectors have been associated with short-lived expression, and viral vectors have been shown to cause toxicity. However, these are problems that an integrase-mediated non-viral gene therapy has the demonstrated potential to overcome.
Visually aesthetic image contrast enhancement (2018)

The existing techniques for local contrast enhancement are designed to produce maximal contrast across the whole image. However, natural photos require selective improvements to emphasize the most valuable objects in the scene only. In this paper, we propose a local contrast enhancement algorithm that utilizes both local contrast distribution and saliency as an input. The proposed approach performs edge-aware processing that guarantees that the distinct objects get the correct contrast. We construct the bilateral grid to measure the contrast distribution in edge-preserving manner and obtain unique tone reproduction curves (TRC) of downsampled image pixels. We further tune TRCs using the saliency map in order to provide visually aesthetic contrast improvement. Finally, we upscale the contrasted image with slicing technique. The proposed approach can be utilized for automated aesthetic enhancement of images or emphasizing objects of interest.
mVps34 is Activated by an Acute Bout of Resistance Exercise (2008)

Resistance exercise (RE) training results in an increase in muscle mass and force production. Amino acids (AA) taken immediately before or after RE potentiate the effects of training on muscle mass. Therefore a protein that controls AA availability would be of interest in studying muscle growth. One candidate is the class 3 phosphatidylinositol 3OH‐kinase (PI3K) Vps34. Mammalian Vps34 (mVps34) is involved in both autophagy and AA signalling to mTOR (mammalian target of rapamycin) and its downstream target p70 S6 kinase (S6K1). To determine the role of mVps34 in mTOR activation following RE we measured mVps34 and S6K1 activity in the distal hindlimb muscles of rats 30 mins, 3, 6 and 18 hr after acute stimulation. In the tibialis anterior (TA) we found a 366.3±112.1 (p=0.04), 124.7±16 (p=0.01) and 129.2±0.1 (p=0.01) percent increase in S6K1 activity at the 30 min, 3 and 6 hr time points respectively. mVps34 activity increased only at the 3 and 6 hr time point in the TA muscle showing a 100.9±18.2 (p=0.01) and 36±8.8 (p=0.02) percent increase respectively. We have also shown an increase in S6K1 Thr389 phosphorylation and a 43±5.2 (p=0.02) percent increase in mVps34 activity in response to low Dexamethasone in C2C12 cells suggesting regulation through internal AA. We propose that a decrease in [AA] following RE activates mVps34 in order to replenish the AA pool maintaining mTOR activity.
A low voltage SiGe BJT integrated RF amplifier with very high third order intercept point (2006)

We present a 0.7 to 1.3 GHz RF amplifier with very high third order intercept point (IP3) for use in an integrated receiver. The amplifier is designed in a modern high volume commercial SiGe HBT process and operates with a collector voltage of 1.8 V. An integrated shunt diode linearizer, inductive emitter degeneration, and output impedance matching are all optimized together to achieve an IP3 of +40 dBm with an IP3/Pdc figure of merit ratio of 18.5. This combination of techniques has resulted in unprecedented linearity for a design in a silicon process with a low breakdown voltage
Transport of bacteria in porous media: I. An experimental investigation (1994)

The convective transport of concentrated suspension of bacteria in porous media is of interest for several processes such as microbial enhanced oil recovery and in situ bioremediation. The parameters which affect the transport of the bacterium Bacillus licheniformis JF-2, a candidate microorganism for microbial enhanced oil recovery, were investigated experimentally in sandpacks. Bacteria retention and permeability reduction occurred primarily in the first few centimeters upon entering the porous medium. In downstream sections of the sandpack, the permeability reduction was low, even in cases in which high cell concentrations (10(8) cfu/mL) were detected in the effluent. The effect of (i) addition of a dispersant, (ii) linear velocity of injection, (iii) cell concentration, (iv) salinity (v) temperature, and (vi) the presence of a residual oleic phase were determined experimentally. A lower reduction in permeability and a higher effluent bacterial concentration were obtained in the presence of dispersant, high injection velocities, low salinities, and at a higher temperature. Macroscopic measurements at different linear velocities and in the presence or absence of dispersants suggest that the formation of reversible microaggregates and multiparticle hydrodynamic exclusion may be the primary mechanisms for bacterial retention and permeability reduction. (c) 1994 John Wiley & Sons, Inc.
Electronmicroscopic Observation of Print-Out Effect on AgBr Crystals Obtained from Low Sensitive Photographic Plate (1969)

The print-out effects due to xenon light illumination were studied electronmicroscopically in the temperature range from room temperature to 250°C on comparatively perfect silver bromide crystals obtained from the low sensitive photographic plate. As a result, it was found that a few pits appeared on the edges of the grains differing from the case of the grains obtained from the SSS photographic film already reported 1) . Triangular patterns 1,2) hardly appeared on the grains at room temperature -250°C. Various silver protrusions bounded almost with (100) crystal surfaces appeared on the grains at 90°C–160°C. Silver whisker grew the grains at 90°C–160°C exposed to xenon light in vacuum. The whisker had two twin planes and its axis was always &lt;110&gt; direction, and also its crystal orientation is parallel to that of its mother crystal. It was confirmed that this whisker grew by the root growth mechanism.
Comparative Measure of the Electronic Influence of Highly Substituted Aryl Isocyanides (2015)

To assess the relative electronic influence of highly substituted aryl isocyanides on transition metal centers, a series of C4v-symmetric Cr(CNR)(CO)5 complexes featuring various alkyl, aryl, and m-terphenyl substituents have been prepared. A correlation between carbonyl-ligand (13)C{(1)H} NMR chemical shift (δCO) and calculated Cotton-Kraihanzel (C-K) force constant (kCO) is presented for these complexes to determine the relative changes in isocyanide σ-donor/π-acid ratio as a function of substituent identity and pattern. For nonfluorinated aryl isocyanides possessing alkyl or aryl substitution, minimal variation in effective σ-donor/π-acid ratio is observed over the series. In addition, aryl isocyanides featuring strongly electron-releasing substituents display an electronic influence that nearly matches that of nonfluorinated alkyl isocyanides. Lower σ-donor/π-acid ratios are displayed by polyfluorinated aryl isocyanide ligands. However, the degree of this attenuation relative to nonfluorinated aryl isocyanides is not substantial and significantly higher σ-donor/π-acid ratios than CO are observed in all cases. Substituent patterns for polyfluorinated aryl isocyanides are identified that give rise to low relative σ-donor/π-acid ratios but offer synthetic convenience for coordination chemistry applications. In order to expand the range of available substitution patterns for comparison, the syntheses of the new m-terphenyl isocyanides CNAr(Tripp2), CNp-MeAr(Mes2), CNp-MeAr(DArF2), and CNp-FAr(DArF2) are also reported (Ar(Tripp2) = 2,6-(2,4,6-(i-Pr)3C6H2)2C6H3); p-MeAr(Mes2) = 2,6-(2,4,6-Me3C6H2)2-4-Me-C6H2); p-MeAr(DArF2) = 2,6-(3,5-(CF3)2C6H3)2-4-Me-C6H2); p-FAr(DArF2) = 2,6-(3,5-(CF3)2C6H3)2-4-F-C6H2).
Eccentric Dipole in a Spherical Medium: Generalized Expression for Surface Potentials (1973)

A new formulation is presented for surface potentials produced on a homogeneous spherical volume conductor by an eccentric current dipole contained therein. The formulation is free of interminancies for all relevant dipole locations and leads directly to the solution of surface potentials due to an eccentric quadripole.
NOVEL FLEXION-RESTRICTING STABILIZATION SYSTEM RESTORES STABILITY IN FLEXION AND TRANSLATION AFTER SIMULATED INJURY (2012)

Statement of Purpose The purpose of this experiment was to characterize the biomechanical properties of a minimally-invasive flexion-restricting stabilization system (FRSS) developed to address flexion instability. Background Lumbar flexion instability is associated with degenerative pathology such as degenerative spondylolisthesis (DS) as well as resection of posterior structures during neural decompression. Flexion instability may be measured by increased total flexion/extension range of motion (ROM), as well as reduced stiffness within the high flexibility zone (HFZ, the range in which most activities occur). Flexion and segmental translation are known to be coupled; therefore increased flexion may exacerbate translational instability, particularly in DS. Method Five cadaveric lumbar spines were tested intact; after L4-L5 destabilization including nucleotomy and midline decompression; and following restabilization with the FRSS secured to the spinous processes. Specimens were loaded in flexion (8Nm) and extension (6Nm) under 400N compressive follower preload. Flexion stiffness in the HFZ and segmental translation were also measured. Results Destabilization increased L4-L5 flexion by 69%±31% (p Discussion and Conclusion The destabilization modeled here simulated degenerative and iatrogenic destabilizations often seen clinically. Implantation of the FRSS on the destabilized segments restored flexion, stiffness and translation to intact levels. The segmental coupling of translation and flexion seen in this experiment indicates that translation may be manipulated by altering flexion kinematics. The FRSS represents a novel system for treating flexion and translational instabilities.