gebhart/patrepeval huggingface dataset:
Abstract 145: Development of Novel S100A9 Peptide Vaccine for Prevention of Thrombus Formation in Ischemic Stroke in Mice (2017)

Background and purpose: Nonadherence of antithrombotic medicine is one of major risk factors for recurrent strokes. Immunotherapy, such as antithrombotic vaccination, is expected to solve such a problem due to its long-lasting effects. Here, we focused on platelet-derived S100A9, which has directly regulate thrombosis without influence on hemostasis, and examined the antithrombotic effects of newly developed S100A9 vaccine in mice. Methods: S100A9 vaccine was designed to select the short peptide as an antigen of S100A9 conjugated to keyhole limpet hemocyanin (KLH). Male C57BL/6J mice were immunized with S100A9 vaccine three times at 2 weeks interval. Middle cerebral arteries (MCA) was exposed to topical application of 20% ferric chloride. The time to occlude the MCA was examined measuring cerebral blood flow with a laser doppler flowmeter. Bleeding time was assessed by cutting the tail arteries. The thrombus formation was also assessed using the laminar flow chamber. The influences of vaccine for T-cell activation were assed using an IgG subclass ELISA and an enzyme-linked immunosorbent spot (ELISPOT) assay. Results: S100A9 vaccine successfully produced antibodies specific for S100A9 in serum in a dose-dependent manner. After the third immunization, the time to thrombus formation in MCA was significantly prolonged in the mice vaccinated with S100A9 compared to the non-immunized mice (23.3 ± 4.3 min vs 6.9 ± 0.8 min, p&lt;0.01), but bleeding time was same in both groups. There was no significant difference in platelet count in both groups. The formation of platelet thrombus under ex vivo was significantly reduced in S100A9 vaccine group compared to control group (14.8 ± 0.7 x10 4 /μm 2 vs 17.8 ± 0.9 x10 4 /μm 2 , p&lt;0.05). In the IgG subclass ELISA, the IgG1:IgG2b ratio was greater than 1.0 in the S100A9 vaccine group. In the ELISPOT assay using splenocytes isolated from S100A9 immunized mice, stimulation with S100A9 partial peptide did not induce the production of IFN-gamma and IL-4 in comparison with KLH. Conclusion: The S100A9 vaccine could successfully prevent thrombus formation in MCA without influence on hemostasis nor eliciting an autoimmune response. S100A9 vaccine might shed light on the development of safe antithrombotic vaccine in ischemic stroke.
Molecular dynamics simulations of liquid crystal molecules adsorbed on graphite (1995)

Abstract Preliminary results are presented on molecular dynamics simulations of the alignment of 8CB (4-n-octyl-4′-cyanobiphenyl) liquid crystal molecules on a graphite surface. Their stable alignment direction was found to be the <31 20> direction of the basal plane of graphite. The calculated adsorption energy of an 8CB molecule was 151·5 kJ mol −1 and its alkyl chain was the main adsorption portion. Molecular dynamics simulation could therefore be an effective probe to the surface-induced alignment mechanism of liquid crystal molecules.
Passive Wireless SAW Temperature Sensor System Specified Low-Power Radio Stations (2019)

This paper reports an evaluation scheme that prevents phase ambiguity of surface acoustic wave (SAW) sensors. We realized a wide range and high precision of temperature measurement by using both delay time and phase for the passive wireless SAW temperature sensor system specified low-power radio stations.
Tristetraprolin Is Required for Full Anti-Inflammatory Response of Murine Macrophages to IL-10 (2009)

IL-10 is essential for inhibiting chronic and acute inflammation by decreasing the amounts of proinflammatory cytokines made by activated macrophages. IL-10 controls proinflammatory cytokine and chemokine production indirectly via the transcription factor Stat3. One of the most physiologically significant IL-10 targets is TNF-alpha, a potent proinflammatory mediator that is the target for multiple anti-TNF-alpha clinical strategies in Crohn's disease and rheumatoid arthritis. The anti-inflammatory effects of IL-10 seem to be mediated by several incompletely understood transcriptional and posttranscriptional mechanisms. In this study, we show that in LPS-activated bone marrow-derived murine macrophages, IL-10 reduces the mRNA and protein levels of TNF-alpha and IL-1alpha in part through the RNA destabilizing factor tristetraprolin (TTP). TTP is known for its central role in destabilizing mRNA molecules containing class II AU-rich elements in 3' untranslated regions. We found that IL-10 initiates a Stat3-dependent increase of TTP expression accompanied by a delayed decrease of p38 MAPK activity. The reduction of p38 MAPK activity releases TTP from the p38 MAPK-mediated inhibition, thereby resulting in diminished mRNA and protein levels of proinflammatory cytokines. These findings establish that TTP is required for full responses of bone marrow-derived murine macrophages to IL-10.
Tregs in T cell vaccination: exploring the regulation of regulation (2004)

T cell vaccination (TCV) activates Tregs of 2 kinds: anti-idiotypic (anti-id) and anti-ergotypic (anti-erg). These regulators furnish a useful view of the physiology of T cell regulation of the immune response. Anti-id Tregs recognize specific effector clones by their unique TCR CDR3 peptides; anti-id networks of CD4(+) and CD8(+) Tregs have been described in detail. Here we shall focus on anti-erg T regulators. Anti-erg T cells, unlike anti-id T cells, do not recognize the clonal identity of effector T cells; rather, anti-erg T cells recognize the state of activation of target effector T cells, irrespective of their TCR specificity. We consider several features of anti-erg T cells: their ontogeny, subset markers, and target ergotope molecules; mechanisms by which they regulate other T cells; mechanisms by which they get regulated; and therapeutic prospects for anti-erg upregulation and downregulation.
Highly Efficient Deep Blue Fluorescent Organic Light-Emitting Diodes Boosted by Thermally Activated Delayed Fluorescence Sensitization (2018)

Highly efficient deep blue fluorescent material and various thermally activated delayed fluorescent (TADF) blue sensitization materials were synthesized for fluorescent deep blue organic light-emitting diodes (OLEDs). These materials were designed and selected by considering efficient energy transfer conditions (i.e., spectral overlap and quantum efficiency) between sensitizer and acceptor. Energy transfer process from TADF host sensitizers to deep blue fluorescent emitter has been investigated by measuring the energy transfer rate. Measured energy transfer rate was to be 1.24 × 10<sup>10</sup> s<sup>-1</sup> (mol/dm<sup>3</sup>)<sup>-1</sup> for a prompt decay of fluorescence and 2.61 × 10<sup>8</sup> s<sup>-1</sup> (mol/dm<sup>3</sup>)<sup>-1</sup> for delayed fluorescence, which demonstrated the efficient energy transfer. Indeed, highly efficient deep blue fluorescent OLEDs boosted by the TADF host-sensitization process were successfully fabricated. The maximum external quantum efficiency was 19.0% with color coordinates of (0.14, 0.15) and 15.5% with color coordinates of (0.15, 0.11) in the different host system. The efficiency roll-off characteristic and device operating lifetime were also improved by this efficient sensitization process.
21.4: Thin Film Encapsulated Flexible OLED Displays (2003)

Abstract Fully encapsulated passive matrix, video rate, phosphorescent OLED displays on flexible plastic substrates using a multilayer barrier encapsulation technology are described. The flexible OLED (FOLED™) displays are based on highly efficient electrophosphorescent OLED (PHOLED™) technology deposited on barrier coated plastic film (Flexible Glass™ substrate) and are hermetically sealed with an optically transmissive multilayer barrier coating (Barix™ Encapsulation). Preliminary lifetime to half initial luminance (L o ∼100 cd/m 2 ) of order 200 h is achieved on the encapsulated 80 dpi displays using a passive matrix drive at room temperature; 2500 h lifetime is achieved on a dc tested encapsulated 5 mm 2 FOLED test pixel. The encapsulated displays are flexed 1000 times around a 1″ diameter cylinder and show minimal damage.
Development of LPE-grown HgCdTe 64 x 64 FPA with a cutoff wavelength of 10.6 μm (1993)

We have developed a hybrid HgCdTe focal plane array (FPA) for wavelengths from 8 to 11 micrometers . We describe how we fabricated our back illuminated 64 X 64-element photodiode array on a liquid phase epitaxial (LPE) HgCdTe wafer, and a Si CCD multiplexer with line address readout. We optimized carrier concentration in the p-type HgCdTe layer to maximize charge injection efficiency to the Si CCD readout circuit to more than 99.3%. We achieved excellent uniformity of characteristics of the photodiode array, which is very important for an IRFPA, by using LPE HgCdTe grown with a tipping method, and passivating the photodiode array with an anodic sulfide of HgCdTe. We obtained an average product of zero-bias resistance and area (RoA) of 9.1 (Omega) cm<SUP>2</SUP> with a cutoff wavelength of 10.6 micrometers at 77 K. We used line address readout to give a large charge storage capacity of 4 X 10<SUP>7</SUP> electrons. We estimated a noise equivalent temperature difference (NETD) of 0.08 K with F/2.5 optics, including fixed pattern noise. We tried some preliminary experiments to reduce the crosstalk from photogenerated carriers which spread laterally into the epitaxial layer. We improved the modulation transfer function (MTF) at Nyquist spatial frequency from the conventional 35% to 60% by using a crosswise drain structure around each photosensitive n<SUP>+</SUP> on p diode.
Arthroscopically assisted placement of a supracondylar intramedullary nail: Operative technique (1995)

The use of retrograde interlocking intramedullary nails has been described for the treatment of selected supracondylar fractures. A medial parapatellar incision and arthrotomy with its attendant morbidity is generally used for nail placement. Although a closed technique of nail placement has been described, the risks of damaging intra-articular structures with a blind approach have precluded the widespread use of this method. In this article, we present a simple, arthroscopically assisted method for the retrograde intramedullary nailing of supracondylar femoral fractures. This technique affords the potential benefits of intramedullary fixation of these fractures while avoiding the morbidity and complications associated with an arthrotomy. Potential benefits over the standard placement using an arthrotomy include earlier ambulation and soft tissue healing, decreased risk of damage to the knee joint, earlier convalescence with decreased hospitalization time, and better cosmesis.
Multi-segment tapered optical mirror for MEMS LiDAR application (2017)

In this work, we present a novel and simple optical solution for MEMS LiDARs. The idea is based on increasing the collection optics throughput by removing the MEMS mirror from the path of the collected light, while inserting a multi-segment tapered structure to collect the light from a wide angle. The tapered also converts the large size optical spot captured to a small area compatible with the requirement of low detector noise dimensions. The expected improvement in the collected power is analyzed versus the tapering angle of a single tapered structure. A multi-segment optical system, or multiple tapered structure arranged in parallel, is also introduced allowing for the optimization of the acceptance angle and the power improvement ratio. Using a 3-segment mirror, the expected improvement is about 15x with an acceptance angle of &plusmn;30 degrees. The design of a single element taper section is fabricated using aluminum-coated acrylic and tested experimentally showing an improvement of about 7x in the coupled power through an angle of &plusmn;10 degrees in good agreement with the theoretical expectations.
Effect of Coating and Particle Properties on the Cycling Stability of Li-Ion Conductor (LIC) Coated Sulfur Cathodes (2015)

Introduction Among the available energy-storage technologies, lithium batteries will play an increasingly important role because of their high specific energy and energy density. Since their introduction in 1991, Li-ion batteries have transformed portable electronic devices. New generations of such batteries will transform transport and find use in stationary electricity storage. Extensive research in lithium-ion anode technologies have made it possible to obtain 1,950 mAh/g anode capacities with stable performance (1-3). However the current cathodes plays a limiting role with a maximum achieved capacity five folds lower than that of the anode (4). Reaching beyond the horizon of Li-ion batteries is a serious challenge and requires the exploration of new chemistries, especially related to the electrochemistry, and new materials development. Li-S battery which works on the ‘conversion’ principle is a promising candidate for this purpose. Sulfur has a theoretical capacity of 1672 mAh/g, representing to nearly 6, 11 and 10 fold improvement in capacity as compared to LiCoO 2 , LiMn 2 O 4 and LiFePO 4 respectively. Since the first demonstration of LiS batteries, research has burgeoned at an alarming rate in this exciting field. However, this technology still has many challenges due to the poor conductivity of sulfur and more importantly, the polysulfide dissolution. Polysulfide originally dissolves as short chain and grows into a longer chain, eventually resulting in the loss of active material and capacity fade. Polysulfide dissolution is a serious issue yet to be addressed economically. Previous work from our group(5) demonstrates a very effective method to prevent polysulfide dissolution by coating a thin layer of Lithium Ion Conductor (LIC) over nano-sulfur anode in a multilayer architecture. This approach resulted in a stable capacity of ~600mAh/g for over 60 cycles with minimal fade. In this work, we attempt to enhance the capacity and stability by altering the size of the active sulfur nanomaterials and engineering the porosity of LIC layer on the performance of the battery. Figure 1 depicts an LIC coated sulfur electrode with tailored porosity and pore volume. Using dynamic light scattering the size of nanoparticles is analyzed and porosity and pore volume are studied using mercury porosimetry, envelope density measurement and BET surface area analysis. Results of these studies will be presented and discussed. Captions Figure 1: SEM image of the LIC coated sulfur electrodes(5). References 1. M. K. Datta, J. Maranchi, S. J. Chung, R. Epur, K. Kadakia, P. Jampani and P. N. Kumta, Electrochimica Acta , 56 , 4717 (2011). 2. R. Epur, M. K. Datta and P. N. Kumta, Electrochimica Acta , 85 , 680 (2012). 3. W. Wang, R. Epur and P. N. Kumta, Electrochemistry Communications , 13 , 429 (2011). 4. J. Chen, Materials , 6 , 156 (2013). 5. P. J. Hanumantha, B. Gattu, O. Velikokhatnyi, M. K. Datta, S. S. Damle and P. N. Kumta, Journal of The Electrochemical Society , 161 , A1173 (2014). Figure 1
The Cys 4 zinc finger of bacteriophage T7 primase in sequence-specific single-stranded DNA recognition (1999)

Bacteriophage T7 DNA primase recognizes 5'-GTC-3' in single-stranded DNA. The primase contains a single Cys4 zinc-binding motif that is essential for recognition. Biochemical and mutagenic analyses suggest that the Cys4 motif contacts cytosine of 5'-GTC-3' and may also contribute to thymine recognition. Residues His33 and Asp31 are critical for these interactions. Biochemical analysis also reveals that T7 primase selectively binds CTP in the absence of DNA. We propose that bound CTP selects the remaining base G, of 5'-GTC-3', by base pairing. Our deduced mechanism for recognition of ssDNA by Cys4 motifs bears little resemblance to the recognition of trinucleotides of double-stranded DNA by Cys2His2 zinc fingers.
Aggregating interdependent sensory data in multisensor systems (2002)

The authors investigate the issue of information interdependence in multisensor systems. A consensus group approach which accounts for interdependence between group sensors is presented. The approach is based on an information theory formulation. An algorithm for computing a weighting scheme for the group sensors is developed. The algorithm rewards each sensor for the quality of its measurements and penalizes it for its interdependence with other sensors in the group.
First Report of Successful Total Pancreatectomy and Islet Autotransplant in Australia (2017)

Geyer, Myfanwy Clare MBBS, FRACP; Coates, Patrick Toby MBBS, FRACP, PhD; Khurana, Sanjeev MBBS, MS FRCSI, FRACS; Chen, John W.C. MBBS, FRACP, PhD; Kay, Thomas W.H. BMedSci, MBBS, FRACP, PhD, FRCPA; Balamurugan, Appakalai N. PhD; Couper, Jennifer J. MBChB, MD, FRACP; Radford, Toni RN; Drogemuller, Christopher J. BBioTech(Hons); Loudovaris, Thomas PhD; Pathi, Ramon MBBS(Hons), FRANZCR; Wilks, Michael John MBBS, FRANZCR; Couper, Richard Thomas Lee MBChB, FRACP Author Information
Synthesis and characterization of dendrimer-based nitric oxide delivery systems (2019)

Nitric oxide (NO) has garnered much attention as a therapeutic due to its multifaceted role in human physiology. However, NO is a highly reactive radical, making its chemical storage and controlled release extremely challenging. Although several small molecule NO donors have been reported in the literature, the limited NO storage and the inability to target NO to a specific site of action have seriously hindered the clinical utility of NO donors. To address these limitations, my research has focused on the synthesis of macromolecular NOreleasing dendrimers that store large quantities of NO (1–5 imol NO/mg). Herein, the synthesis and characterization of two systems are presented employing the two most common small molecule NO donors: N-bound diazeniumdiolates and S-nitrosothiols. Decomposition of the diazeniumdiolate NO donor was proton initiated under aqueous conditions with the NO release being highly influenced by the local dendritic environment. S-nitrosothiol dendrimer conjugates were subject to decomposition by various triggers of NO release (e.g., copper and light) and also shown to directly transfer NO to proteins via transnitrosation. The systems described in this thesis represent two of the highest NO-releasing nanoparticle NO donors reported to date. Additionally, studies investigating the cytotoxicity of multifunctional dendrimer conjugates and the physiological activity of dendrimer derived nitric oxide are presented.
Characterization of an Isotype-Dependent Monoclonal Antibody against Linear Neutralizing Epitope Effective for Prophylaxis of Enterovirus 71 Infection (2012)

Background: Enterovirus 71 (EV71) is the main causative agent of Hand, Foot and Mouth disease (HFMD) and is associated with severe neurologic complications and mortalities. At present, there is no vaccine or therapeutic available for treatment.
In situ intercalative polymerization of pyrrole in Fe0Cl: a new class of layered, conducting polymer-inorganic hybrid materials (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIn situ intercalative polymerization of pyrrole in Fe0Cl: a new class of layered, conducting polymer-inorganic hybrid materialsM. G. Kanatzidis, L. M. Tonge, T. J. Marks, H. O. Marcy, and C. R. KannewurfCite this: J. Am. Chem. Soc. 1987, 109, 12, 3797–3799Publication Date (Print):June 1, 1987Publication History Published online1 May 2002Published inissue 1 June 1987https://pubs.acs.org/doi/10.1021/ja00246a057https://doi.org/10.1021/ja00246a057research-articleACS PublicationsRequest reuse permissionsArticle Views775Altmetric-Citations181LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Spatially Localized Photoluminescence at 1.5 Micrometers Wavelength in Direct Laser Written Optical Nanostructures (2008)

DOI: 10.1002/adma.200801508 The following errors appear in the above article: The inset of Figure 3 was missing. The correct representation of Figure 3 is shown here: SEM image of the step-ladder structure with one of the supporting walls removed via FIB milling. The position of the Er-doped layer is highlighted with a red line as a guide to the eye. The bars are systematically shifted vertically in 200nm steps relative to the doping layer, starting from the substrate (top left side of the SEM image). High-magnification SEM imaging of the Er/As2S3 layer (inset) shows that it has a thickness of 139nm (this value takes into account a sample stage tilt of 54°). Several characters in Figure 4 were incorrectly displayed. The correct representation of Figure 4 is shown below: a) A schematic of the step-ladder structure (center), and the results of the spatially resolved confocal PL imaging technique in the 1D line-scan mode (bottom) and 2D imaging mode (inset). b) A representative cross-section SEM image of the bars (left) that were examined to construct a model (centre) used to show the progression of the Er doping layer in the bars situated between at the positions between 5 and 65 µm of the step-ladder structure (right). c) SEM images of bars positioned above the erbium doping layer (highlighted in red). Part of the highlighting is removed to show actual Er/As2S3 layer (indicated with a red-arrow).
Direct observation of x-ray radiation-induced damage to SiO2/Si interface using multiwavelength room temperature photoluminescence (2016)

Higher failure rates have been observed for devices at or adjacent to areas that have been measured or inspected by in-line x-ray during front end of line process steps. The failures are thought to be related to SiO2/Si interface damage caused by x-ray radiation during routine in-line element, material, and process monitoring. This issue has been noted for highly advanced integrated semiconductor devices following device failure mode analysis of Si wafers, with and without x-ray in-line inspection. A multiwavelength room-temperature photoluminescence (RTPL) study was performed to identify the presence of such damage in x-ray irradiated wafers from various types of x-ray inspection steps during device fabrication processes. It was found that x-ray radiation as low as 16 keV induced damage at the SiO2/Si interface. The damage to the SiO2/Si interface was successfully observed by using multiwavelength RTPL wafer mapping.