gebhart/patrepeval huggingface dataset:
Contribution of Subregions of Human Frontal Cortex to Novelty Processing (2011)

Novelty processing was studied in patients with lesions centered in either OFC or lateral pFC (LPFC). An auditory novelty oddball ERP paradigm was applied with environmental sounds serving as task irrelevant novel stimuli. Lesions to the LPFC as well as the OFC resulted in a reduction of the frontal Novelty P3 response, supporting a key role of both frontal subdivisions in novelty processing. The posterior P3b to target sounds was unaffected in patients with frontal lobe lesions in either location, indicating intact posterior cortical target detection mechanisms. LPFC patients displayed an enhanced sustained negative slow wave (NSW) to novel sounds not observed in OFC patients, indicating prolonged resource allocation to task-irrelevant stimuli after LPFC damage. Both patient groups displayed an enhanced NSW to targets relative to controls. However, there was no difference in behavior between patients and controls suggesting that the enhanced NSW to targets may index an increased resource allocation to response requirements enabling comparable performance in the frontal lesioned patients. The current findings indicate that the LPFC and OFC have partly shared and partly differential contributions to the cognitive subcomponents of novelty processing.
ProDisc-C and Anterior Cervical Discectomy and Fusion as Surgical Treatment for Single-Level Cervical Symptomatic Degenerative Disc Disease (2012)

Five-year results show that TDR with ProDisc-C is a safe and effective treatment of single-level symptomatic cervical disc disease. Clinical outcomes were comparable with ACDF. ProDisc-C patients maintained motion at the index level and had significantly less neck pain intensity and frequency as well as a lower probability of secondary surgery.
2.4 µm cutoff wavelength avalanche photodiode on InP substrate (2006)

An InP-based avalanche photodiode with a cutoff wavelength of 2.4 µm is reported. Type-II GaInAs-GaAsSb quantum wells lattice-matched to InP were used in the absorption region of the photodiode for long-wavelength absorption. The device exhibited multiplication gain in excess of 30 at room temperature and in excess of 200 at 225 Kelvin with dark current density near breakdown of less than 0.66 mA/cm2.
Room temperature CW operation of GaInP/AlGaInP multiple quantum wire visible lasers (MQWR-LD) (2002)

The first successful room temperature (r.t.) CW operation of GaInP/AlGaInP multiple quantum wire visible lasers was obtained, with the maximum CW temperature of 70/spl deg/C. For uncoated facet condition at 20/spl deg/C, the threshold current density (Jth) was 294 A/cm/sup 2/, the output power 50 mW/facet, and the differential quantum efficiency 37%. The low pulse Jth value of 277 A/cm/sup 2/ was obtained.
Detecting seizure patterns in patients with Alzheimer’s disease using long‐term EEG monitoring: A feasibility study (2020)

Abstract Background Seizure patterns as detected with electroencephalography (EEG) has been suggested to be frequent in patients with Alzheimer’s disease. However, long‐term EEG monitoring to detect seizure patterns requires hospitalization for longer periods of time, which is both expensive and difficult for patients with Alzheimer’s disease.In the current feasibility study, we investigated whether it was possible for patients with Alzheimer’s disease to wear ear‐EEG for long‐term EEG monitoring of seizure patterns at home. Method We recruited patients who met the criteria for Alzheimer’s disease and had no previous history of epilepsy. Seizure patterns was assessed using long‐term EEG monitoring with ear‐EEG for 48 hours every three months for half a year. Furthermore, patients and relatives were instructed in the use of a seizure diary, which was used during the ear‐EEG recordings. Result So far, we have recruited 9 patients with Alzheimer’s disease, and all patients who underwent ear‐EEG monitoring have been able to wear the ear‐EEG for at least 24 hours including sleep. We are currently in the process of investigating whether the patients with Alzheimer’s disease show seizure patterns as measured with ear‐EEG. Conclusion Long‐term EEG monitoring using ear‐EEG seems to be feasible for measuring seizure patterns in patients with Alzheimer’s disease. If any of the patients show seizure patterns using ear‐EEG, we will be able to treat with anti‐epileptic medication, which may improve their symptoms.
Multilayer Platform for Ultra-Low-Loss Waveguide Applications (2012)

We investigate a multilayer vertical stacking scheme for use in the Silicon Nitride-based low-loss waveguide platform. In this letter, we use common fabrication techniques to produce test structures for probing the interactions between vertically separated parallel waveguide planes and the characteristics of vertical directional couplers. Single-mode and multimode waveguide geometries are investigated, with designs similar to our previously demonstrated ultra-low-loss technologies. Group index measurements via narrowband OFDR reveal an index mismatch between the vertically separated waveguides of 8.6e-3, generated by the stress of the deposited upper cladding. Vertical directional couplers with a 3-μm vertical coupling gap and a 50 nm × 4 μm geometry exhibited an excess coupling loss of 0.19±0.20 dB and cross-coupled power of 54%, limited by the aforementioned velocity mismatch. The 1.23-m spiral structures with perpendicular crossings on adjacent layers show a transmission loss of the crossings below 0.25 dB for a multimode geometry, while the single-mode design showed a minimum crossing loss of 1.0 dB.
ChemInform Abstract: SYNTHESES OF ANALGESICS PART 39, SYNTHESIS OF 1,2,3,4,5,6‐HEXAHYDRO‐8‐HYDROXY‐2,6‐METHANO‐3,6,11‐TRIMETHYL‐2,3‐BENZO(G)DIAZOCINE AND 1,2,3,4,5,10,11,12‐OCTAHYDRO‐7‐HYDROXY‐1,5‐DIMETHYLPYRIDAZINO(2,3‐B)ISOQUINOLINE (SYNTHESES OF HETEROCYCLIC COMPOUNDS PART 61) (1974)

Abstract 3‐Methoxy‐benzaldehyd (I) kondensiert mit Nitroäthan (II) zum Olefin (III), das über das Keton (IV) in die Methyl‐Verbindung: ′ (V) umgewandelt wird.
High Power MQW Electroabsorption Modulator with a Waveguide Taper (2007)

Peripheral coupled waveguide (PCW) electro-absorption modulator (EAM) with different dimensions is studied. By incorporating a waveguide taper in the PCW to reduce the absorption at the input facet of the EAM, we show that the saturation effect due to high current density can be reduced.
Supplementary Figure 1 from Identification of a Novel Tumor Suppressor Gene <i>p34</i> on Human Chromosome 6q25.1 (2023)

Supplementary Figure 1 from Identification of a Novel Tumor Suppressor Gene &lt;i&gt;p34&lt;/i&gt; on Human Chromosome 6q25.1
Physical mechanisms governing the hydrodynamic response of an oscillating ultrasonic file (1994)

Ultrasonically driven vibrating files are known to enhance the efficiency of root canal debridement. This paper presents a phenomenological view of the hydrodynamic response of an oscillating ultrasonic file and the relationship between the file response and various physical factors such as file size and curvature, file surface properties, file velocity amplitude, root canal geometry, and the type of irrigant. Relevant hydrodynamic properties include the propensity of a file to produce stable and transient cavitation, steady streaming, and cavitation microstreaming. These relationships were explored by experiment. Sonoluminescence was employed as an indicator of transient cavitation activity and photographic analysis was utilized as a means for detecting steady streaming, microstreaming, and stable cavitation. Measurements failed to indicate any strong correlation between registered driving power and the propensity to produce transient cavitation. Files that were pitted or possessed salient edges were very effective at generating transient cavitation. When observed, transient cavitation activity generally occurred near the tip of the straight file, provided the wall-loading did not inhibit file motion. In all cases studied, steady streaming and stable cavitation were observed to varying degrees, depending on the amount of file to wall contact. Stable cavitation was probably enhanced by the addition of moderate amounts of dissolved gas into the irrigant. Although the imposition of file-wall contact served to inhibit the production of transient cavitation, this action had relatively little effect on the ability of a file to produce a nominal level of streaming, microstreaming, and stable cavitation. The relationship between these hydrodynamic properties and the process of root canal debridement is addressed. Observations suggest that it is not prudent to ascribe enhanced cleaning effects to any one phenomenon, for it is likely that several factors are involved to varying degrees depending on the local conditions of application.
A phase I clinical trial of PSMA-directed/TGFβ-insensitive CAR-T cells in metastatic castration-resistant prostate cancer. (2020)

TPS269 Background: Adoptive immunotherapy with Chimeric Antigen Receptor (CAR)-T cells is a novel approach for the treatment of prostate cancer. However, the prostate cancer immunosuppressive microenvironment, including high levels of TGFβ, may limit the therapeutic potential of re-directed T cells upon tumor infiltration. The inhibition of TGFβ signaling via co-expression of a dominant negative TGFβ receptor (TGFβRdn) can enhance antitumor immunity. Co-expression of TGFβRdn on PSMA-redirected CAR-T cells in in vivo disseminated tumor models led to increased T cell proliferation, enhanced cytokine secretion, resistance to exhaustion, long-term persistence, and greater induction of tumor eradication. Methods: We are conducting a first-in-human phase 1 clinical trial evaluating the safety and preliminary efficacy of lentivirally-transduced PSMA-redirected/TGFβ-insensitive CAR-T cells (CART-PSMA-TGFβRdn) in metastatic CRPC (NCT03089203). In a 3+3 dose-escalation design, patients received a single dose of 1-3 x 10 7 /m 2 (Cohort 1) or 1-3 x 10 8 /m 2 (Cohort 2) CART-PSMA-TGFβRdn cells without lymphodepleting chemotherapy. In Cohort 3, 1-3 x 10 8 /m 2 CART-PSMA-TGFβRdn cells are administered following a lymphodepleting chemotherapy regimen of cyclophosphamide and fludarabine (cy/flu). A currently accruing modified protocol seeks to optimize the therapeutic window with CART-PSMA-TGFβRdn (CAR-T dose of 1-3 x 10 7 /m2 following lymphodepleting cy/flu). Eight patients have received a single dose of CART-PSMA-TGFβRdn. CAR-T expansion and persistence in peripheral blood and trafficking to target tissues is evaluated via quantitative PCR of CART-PSMA-TGFβRdn DNA. Bioactivity of CAR-T cells in peripheral blood is evaluated via multiplex immunoassays. Additional correlative analyses will interrogate the therapeutic contribution of TGFβRdn, as well as early markers of response and resistance to CART-PSMA-TGFβRdn therapy. Clinical trial information: NCT03089203.
A new generation of MEMS middle-infrared spectrometers (2014)

Mid infrared spectroscopy has been developed to a powerful and essential method of material analysis, with a steadily increasing number of industrial and scientific application fields. The so called spectral fingerprint range enables identification of chemical compounds by their unique spectral pattern. To provide a suitable miniaturized and portable MIR spectrometer solution at an affordable price, an existing MEMS NIR spectrometer module which already bases on micro system technology has been expanded in its wavelength range. The developed spectrometer belongs to the category of scanning grating spectrometers. Main component is a fast oscillating micro-mirror which moves sinusoidal with high mechanical precision enabling a high stability of according wavelength axis. This is supported by a highly precise optical tracking of the actual motion. Mono-crystalline silicon guarantees a long-life operation with no wear even under harsh environmental conditions. Spectral signal acquisition is realized by using a TE-cooled MCT single element detector assisted by low noise trans-impedance amplifier. With the help of integrated logic components a data pre-processing takes place, such as averaging, offset subtraction, detector transfer characteristic correction and noise shaping. Due the compact and flexible setup, the spectrometer is suitable for the use in various applications, such as process control in chemical industry, gas mixture analysis or liquid verification. The portability of the device opens up new application possibilities in mobile environment. The advances of the promising technology and its specific applications will be described in this paper. Advanced performance issues of the device be reviewed in detail.
Finding hotspots: development of an adaptive spatial sampling approach (2020)

Abstract The identification of disease hotspots is an increasingly important public health problem. While geospatial modeling offers an opportunity to predict the locations of hotspots using suitable environmental and climatological data, little attention has been paid to optimizing the design of surveys used to inform such models. Here we introduce an adaptive sampling scheme optimized to identify hotspot locations where prevalence exceeds a relevant threshold. Our approach incorporates ideas from Bayesian optimization theory to adaptively select sample batches. We present an experimental simulation study based on survey data of schistosomiasis and lymphatic filariasis across four countries. Results across all scenarios explored show that adaptive sampling produces superior results and suggest that similar performance to random sampling can be achieved with a fraction of the sample size.
Quantitative evaluation of ultrasonic sound fields in anisotropic austenitic welds using 2D ray tracing model (2012)

Ultrasonic investigation of inhomogeneous anisotropic materials such as austenitic welds is complicated because its columnar grain structure leads to curved energy paths, beam splitting and asymmetrical beam profiles. A ray tracing model has potential advantage in analyzing the ultrasonic sound field propagation and there with optimizing the inspection parameters. In this contribution we present a 2D ray tracing model to predict energy ray paths, ray amplitudes and travel times for the three wave modes quasi longitudinal, quasi shear vertical, and shear horizontal waves in austenitic weld materials. Inhomogenity in the austenitic weld material is represented by discretizing the inhomogeneous region into several homogeneous layers. At each interface between the layers the reflection and transmission problem is computed and yields energy direction, amplitude and energy coefficients. The ray amplitudes are computed accurately by taking into account directivity, divergence and density of rays, phase relations as well as transmission coefficients. Ultrasonic sound fields obtained from the ray tracing model are compared quantitatively with the 2D Elastodynamic Finite Integration Technique (EFIT). The excellent agreement between both models confirms the validity of the presented ray tracing results. Experiments are conducted on austenitic weld samples with longitudinal beam transducer as transmitting probe and amplitudes at the rear surface are scanned by means of electrodynamical probes. Finally, the ray tracing model results are also validated through the experiments.
Efficient 1-V Boost Converter Using Sub-50-mV NEMS Without Body Bias (2021)

In this article, for the first time, we present the improvement in efficiency in a low-voltage dc-dc boost converter for the energy-harvesting applications using the experimentally demonstrated sub-50-mV nano electro-mechanical switch (NEMS). As per the measurement results, the sub-50-mV NEMS having a small air gap of only 100 nm exhibits very low hysteresis (<; 20 mV), low turn-on delay (15 ns), and low sub-threshold swing of 2 mV/decade. In addition to this, the fabricated NEMS is a propitious candidate toward ideal power switch with almost zero leakage current and a maximum ON-state conductance value of 0.1 A/(V·μm). This study explores a discontinuous-conduction mode (DCM) boost converter with specifications suitable for energy-harvesting applications using the NEMS-based design. The results are compared with the corresponding design using the MOSFET switches in 0.18- μm CMOS technology. This work illustrates that the NEMS-based DCM boost converter design has an improvement in the efficiency of around 30% at a switching frequency of 10 kHz over CMOS for the same ON-state resistance. This is because the proposed fabricated NEMS has extreme low pull-in voltage (50 mV) and low parasitic capacitances (~3.3 fF/μm).
Supplemental Video M6 from A Systematic Comparison of <sup>18</sup>F-C-SNAT to Established Radiotracer Imaging Agents for the Detection of Tumor Response to Treatment (2023)

&lt;p&gt;Supplemental Video M6. 18FC-SNAT uptake in drug-treated tumors&lt;/p&gt;
ChemInform Abstract: Synthesis of D,L‐myo‐Inositol 1,4,5‐Trisphosphate. (1987)

ChemInformVolume 18, Issue 45 Natural Products ChemInform Abstract: Synthesis of D,L-myo-Inositol 1,4,5-Trisphosphate. A. M. COOKE, A. M. COOKE Tate&Lyle Group Res. Dev., Philip Lyle Memorial Res. Lab., Whiteknights Park, Reading RG6 2BX, Great BritainSearch for more papers by this authorB. V. L. POTTER, B. V. L. POTTER Tate&Lyle Group Res. Dev., Philip Lyle Memorial Res. Lab., Whiteknights Park, Reading RG6 2BX, Great BritainSearch for more papers by this authorR. GIGG, R. GIGG Tate&Lyle Group Res. Dev., Philip Lyle Memorial Res. Lab., Whiteknights Park, Reading RG6 2BX, Great BritainSearch for more papers by this author A. M. COOKE, A. M. COOKE Tate&Lyle Group Res. Dev., Philip Lyle Memorial Res. Lab., Whiteknights Park, Reading RG6 2BX, Great BritainSearch for more papers by this authorB. V. L. POTTER, B. V. L. POTTER Tate&Lyle Group Res. Dev., Philip Lyle Memorial Res. Lab., Whiteknights Park, Reading RG6 2BX, Great BritainSearch for more papers by this authorR. GIGG, R. GIGG Tate&Lyle Group Res. Dev., Philip Lyle Memorial Res. Lab., Whiteknights Park, Reading RG6 2BX, Great BritainSearch for more papers by this author First published: November 10, 1987 https://doi.org/10.1002/chin.198745337AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume18, Issue45November 10, 1987 RelatedInformation
Monolithic electronic-photonic integration in state-of-the-art CMOS processes (2012)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2012.
Education and certification on heart failure of the H eart F ailure A ssociation of the E uropean S ociety of C ardiology (2022)

In order to ensure that the next generation of heart failure specialists will receive highquality training, this document outlines the new European training and certification requirements for physicians with an interest in heart failure and for those working in certified heart failure centres, required by the Heart Failure Association (HFA) of the European Society of Cardiology (ESC).
The oxidation of hydroxylamine by nitric and nitrous acids in the presence of technetium (VII) (2000)

The oxidation of hydroxylamine by nitric acid in the presence of technetium ions at temperatures above ~60°C is an autocatalytic process comprising an induction period and then a catalysed reaction involving HNO 2 , which has accumulated in the solution. Tc ions have no appreciable effect on the reaction rate, which is governed only by the nitric and nitrous acid oxidation reactions of hydroxylamine, but the presence of Tc ions does extend the initial induction period. The rate of hydroxylamine oxidation by HNO 3 in the presence of HNO 2 , that is, after the induction period, was found to be: -d[NH 3 OH + ]/dt = k[NH 3 OH + ][HNO 2 ][HNO 3 ] 3.5 where k = 120±10 l 4.5 mol -4.5 min -1 at T = 80°C, μ = 2 and [H + ] ≤ 2 M. Under these conditions, the reaction apparently has a high activation energy of 160-180 kJ mol -1 . At low temperatures (20-40°C) hydroxylamine is effectively stable in solutions of HNO 3 up to concentrations of ~2 M, whether or not Tc(VII) ions are present. Tc(V) was also observed to form at least one complex on reduction with excess hydroxylamine with an absorption maximum between 467 and 480 nm dependent on the solution acidity.
SciSight: Combining faceted navigation and research group detection for COVID-19 exploratory scientific search (2020)

Tom Hope, Jason Portenoy, Kishore Vasan, Jonathan Borchardt, Eric Horvitz, Daniel Weld, Marti Hearst, Jevin West. Proceedings of the 2020 Conference on Empirical Methods in Natural Language Processing: System Demonstrations. 2020.
Supplementary Figure Legend from Sangivamycin-like Molecule 6 Exhibits Potent Anti-Multiple Myeloma Activity through Inhibition of Cyclin-Dependent Kinase-9 (2023)

&lt;p&gt;PDF file, 92K.&lt;/p&gt;
Ultra-small MOSFETs: the importance of the full Coulomb interaction on device characteristics (2002)

We discuss a full three-dimensional model of an ultrasmall MOSFET, in which the transport is treated by a coupled EMC and molecular dynamics (MD) procedure to treat the Coulomb interaction in real space. Impurities within the device, including the source and drain regions, are treated as discrete charges and are randomly sited according to the nominal doping density of each region. We find that the inclusion of the proper Coulomb interaction significantly affects both the energy and momentum relaxation processes, but also has a dramatic effect on the characteristic curves of the device.
Non-interactive zero-knowledge and its applications (2019)

research-article Share on Non-interactive zero-knowledge and its applications Authors: Manuel Blum Univ. of Calif. Univ. of Calif.View Profile , Paul Feldman MIT MITView Profile , Silvio Micali MIT MITView Profile Authors Info & Claims Providing Sound Foundations for Cryptography: On the Work of Shafi Goldwasser and Silvio MicaliOctober 2019 Pages 329–349https://doi.org/10.1145/3335741.3335757Published:04 October 2019Publication History 29citation576DownloadsMetricsTotal Citations29Total Downloads576Last 12 Months44Last 6 weeks8 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Survey on Standards and Regulations for Wireless Charging of Electric Vehicles (2019)

In the next decades, the number of electric vehicles (EVs) for private use is predicted to increase considerably. Charging the EVs through wireless power transfer (WPT), i.e. wireless charging, has the potential to shorten charging duration of EVs batteries through dynamic charging and it would also improve the safety of static charging in case of wet weather conditions. From 2015, standards and regulations have been released such that common constraints can be defined. Therefore, it is essential to be aware of these regulations before designing an EV wireless charging system, such that it can become an actual application. This paper focuses on the available regulations and standards on EVs charging through WPT. These regulations are explained individually and then, they are compared and discussed mainly in terms of the electromagnetic compatibility (EMC) and exposure of humans to the radiated magnetic field limits. To gain a better understanding, a quantitative and qualitative interpretation of these limits is also given.