gebhart/patrepeval huggingface dataset:
Regulation of urokinase-type plasminogen activator production by cultured human cytotrophoblasts. (1987)

Cultured human cytotrophoblasts synthesize and secrete urokinase-type plasminogen activator (uPA) during the first 24 h of culture, but secretion declines during the subsequent day. In contrast, synthesis and secretion of fibronectin increases during the 2 days of culture. The levels of uPA mRNA parallel the changes in synthesis and secretion of uPA. Treatment of cytotrophoblasts with 8-bromo-cAMP (1.5 mM) transiently raises uPA mRNA levels and uPA secretion. This treatment reduces fibronectin mRNA levels and causes a sustained increase in beta chorionic gonadotropin mRNA content and chorionic gonadotropin secretion. We conclude that a cAMP-mediated process up-regulates uPA expression in cytotrophoblasts. However, the stimulatory effect of the cyclic nucleotide analog on uPA is transient.
A Microvascularized Tumor-mimetic Platform for Assessing Anti-cancer Drug Efficacy (2018)

Assessment of anti-cancer drug efficacy in in vitro three-dimensional (3D) bioengineered cancer models provides important contextual and relevant information towards pre-clinical translation of potential drug candidates. However, currently established models fail to sufficiently recapitulate complex tumor heterogeneity. Here we present a chip-based tumor-mimetic platform incorporating a 3D in vitro breast cancer model with a tumor-mimetic microvascular network, replicating the pathophysiological architecture of native vascularized breast tumors. The microfluidic platform facilitated formation of mature, lumenized and flow-aligned endothelium under physiological flow recapitulating both high and low perfused tumor regions. Metastatic and non-metastatic breast cancer cells were maintained in long-term 3D co-culture with stromal fibroblasts in a poly(ethylene glycol)-fibrinogen hydrogel matrix within adjoining tissue chambers. The interstitial space between the chambers and endothelium contained pores to mimic the "leaky" vasculature found in vivo and facilitate cancer cell-endothelial cell communication. Microvascular pattern-dependent flow variations induced concentration gradients within the 3D tumor mass, leading to morphological tumor heterogeneity. Anti-cancer drugs displayed cell type- and flow pattern-dependent effects on cancer cell viability, viable tumor area and associated endothelial cytotoxicity. Overall, the developed microfluidic tumor-mimetic platform facilitates investigation of cancer-stromal-endothelial interactions and highlights the role of a fluidic, tumor-mimetic vascular network on anti-cancer drug delivery and efficacy for improved translation towards pre-clinical studies.
Measuring error compensation on three-dimensional scans of translucent objects (2011)

The error in three-dimensional (3-D) scans by a 3-D measurement system based upon fringe projection on translucent objects is presented. The dependencies on different material parameters are shown. A model describing the cause of the measurement error is introduced and the possibility of error compensation by shifting measurement points in a normal direction is demonstrated.
Simultaneous NO<sub>X</sub> and CO<sub>2</sub> Reduction for Meeting Future California Air Resources Board Standards Using a Heavy-Duty Diesel Cylinder Deactivation-NVH Strategy (2019)

&lt;div&gt;Commercial vehicles require continual improvements in order to meet fuel consumption standards, improve diesel aftertreatment (AT) system performance, and optimize vehicle fuel economy. Simultaneous reductions in both CO&lt;sub&gt;2&lt;/sub&gt; and NO&lt;sub&gt;X&lt;/sub&gt; emissions will be required to meet the upcoming regulatory targets for both EPA Phase 2 Greenhouse Gas Standards and new Low NO&lt;sub&gt;X&lt;/sub&gt; Standards being proposed by the California Air Resources Board &lt;b&gt;(&lt;/b&gt;CARB). In addition, CARB recently proposed a new certification cycle that will require high NO&lt;sub&gt;X&lt;/sub&gt; conversion while vehicles are operating at lower loads than current regulatory cycles require. Cylinder deactivation (CDA) offers a powerful technology lever for meeting these two regulatory targets on commercial diesel engines. There have been numerous works in the past year showing the benefits of diesel CDA for elevating exhaust temperatures during low-load operation where it is normally too cold for AT to function at peak efficiency. At the same time, CO&lt;sub&gt;2&lt;/sub&gt; and fuel consumption are reduced through a combination of lower pumping and friction losses and improved thermal efficiency in the cylinders that are still firing. However, CDA has the potential to alter the vehicle vibration, and therefore a strategy must be developed to mitigate these NVH issues while taking advantage of the performance benefits mentioned previously. This article focuses on demonstrating the merits of diesel CDA at low load on a heavy-duty diesel engine in a dynamometer test cell. Results show:&lt;ol&gt; &lt;li&gt; &lt;span&gt;1&lt;/span&gt; &lt;div&gt;An NVH recipe to minimize system vibration when using CDA;&lt;/div&gt; &lt;/li&gt; &lt;li&gt; &lt;span&gt;2&lt;/span&gt; &lt;div&gt;Exhaust temperature increase and fuel savings at low load operating modes;&lt;/div&gt; &lt;/li&gt; &lt;li&gt; &lt;span&gt;3&lt;/span&gt; &lt;div&gt;Ability to get the AT hot from a cold start using CDA combined with elevated idle speeds;&lt;/div&gt; &lt;/li&gt; &lt;li&gt; &lt;span&gt;4&lt;/span&gt; &lt;div&gt;CDA operation over HD FTP and the CARB proposed LLC.&lt;/div&gt; &lt;/li&gt; &lt;/ol&gt; &lt;/div&gt;
Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases. (1982)

Human neutrophil cathepsin G and human skin mast cell chymase rapidly convert angiotensin I to angiotensin II with only minor cleavage elsewhere in the molecule. The rate of cleavage is consistent with a potential role for either or both of these enzymes in an alternate pathway for angiotensin II synthesis. Since neither enzyme in inhibited by captopril, an angiotensin converting enzyme inactivator, it is possible that leukocyte and mast cell enzymes may play a significant role in the development of abnormally high local concentrations of angiotensin II, associated with various inflammatory processes.
Figure S5 from BET Inhibitors Suppress ALDH Activity by Targeting <i>ALDH1A1</i> Super-Enhancer in Ovarian Cancer (2023)

&lt;p&gt;ALDH1A1 is not a direct target of BRD4.&lt;/p&gt;
LuCaP Cells Quality Control Data (2017)

STR profiling of LuCaP 23.1 and 86.2 cells
EEG-β/γ spectral power elevation in rat: a translatable biomarker elicited by GABAAα2/3-positive allosteric modulators at nonsedating anxiolytic doses (2014)

Benzodiazepine drugs, through interaction with GABA(Aα1), GABA(Aα2,3), and GABA(Aα5) subunits, modulate cortical network oscillations, as reflected by a complex signature in the EEG power spectrum. Recent drug discovery efforts have developed GABA(Aα2,3)-subunit-selective partial modulators in an effort to dissociate the side effect liabilities from the efficacy imparted by benzodiazepines. Here, we evaluated rat EEG and behavioral end points during dosing of nine chemically distinct compounds that we confirmed statistically to selectively to enhance GABA(Aα2,3)-mediated vs. GABA(Aα1) or GABA(Aα5) currents in voltage clamped oocytes transfected with those GABA(A) subunits. These compounds were shown with in vivo receptor occupancy techniques to competitively displace [(3)H]flumazenil in multiple brain regions following peripheral administration at increasing doses. Over the same dose range, the compounds all produced dose-dependent EEG spectral power increases in the β- and and γ-bands. Finally, the dose range that increased γ-power coincided with that eliciting punished over unpunished responding in a behavioral conflict model of anxiety, indicative of anxiolysis without sedation. EEG γ-band power increases showed a significant positive correlation to in vitro GABA(Aα2,3) modulatory intrinsic activity across the compound set, further supporting a hypothesis that this EEG signature was linked specifically to pharmacological modulation of GABA(Aα2,3) signaling. These findings encourage further evaluation of this EEG signature as a noninvasive clinical translational biomarker that could ultimately facilitate development of GABA(Aα2,3)-subtype-selective drugs for anxiety and potentially other indications.
Adult‐generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles (1999)

The subgranule zone of the dentate gyrus in rats has been shown to be proliferative into adulthood and senescence. However, the connectivity of newly generated, identified neurons in the adult has not been definitively described. In the present study, 9 weeks after a series of intraperitoneal injections of 5-bromo-2′-deoxyuridine (BrdU), animals received stereotaxic iontophoretic injections of Fluoro-Gold (FG) into field CA3. Three weeks after FG injections, sections were analyzed for BrdU immunoreactivity (proliferative label), FG retrograde label, and either calbindin-D28k or synaptophysin immunohistochemistry. A large proportion (up to 44%) of BrdU-labeled cells in the dentate gyrus within regions of FG retrograde label incorporated FG. All of the doubly labeled (BrdU-FG) neurons also immunolabeled with the antibody to calbindin-D28k. Many doubly labeled (BrdU-FG) cells were also surrounded in three planes by synaptophysin immunoreactivity. We conclude that newly generated neurons in the dentate gyrus have the correct immunohistochemical profile, send appropriate axonal projections to field CA3, and are surrounded by profiles containing synaptic vesicle proteins. J. Comp. Neurol. 406:449–460, 1999. © 1999 Wiley-Liss, Inc.
Identification of MMP28 as a biomarker for the differential diagnosis of idiopathic pulmonary fibrosis (2018)

These findings indicate that MMP28 might be a useful biomarker to improve the diagnostic certainty of IPF.
Thread-based multiplexed sensor patch for real-time sweat monitoring (2020)

Abstract Sensor platforms that exploit the fibrous textile threads as substrates offer great promise since they can be directly sewn, woven or stitched on to any clothing. They can also be placed directly in intimate contact with the skin. In this work, we present a thread-based sensing platform in the form of a multiplexed sensing patch for continuous simultaneous on-skin monitoring of sweat. The patch performs real-time, on-body measurements of important biomarkers present in sweat such as electrolytes (sodium and ammonium ions), metabolites (lactate) and acidity (pH). Flexible threads coated with conductive inks were used as sensing electrodes. Selective potentiometric detection of electrolytes and pH was made possible through ion-selective membrane deposition and pH-sensitive polyaniline coating on threads, respectively. An amperometric enzymatic sensing scheme with lactate oxidase was used for the detection of lactate. An array of the thread sensors is integrated onto a patch with connectivity to a miniaturized circuit module containing a potentiostat, microprocessor and wireless circuitry for wireless smartphone readout. Extensive in vitro validation and an in vivo human pilot study involving a maximal exertion test show the promise of this platform for real-time physiological monitoring of human performance/fitness under stress, as well as diagnostic monitoring through sweat analysis.
Quantitative Oropharyngeal Epstein-Barr Virus Shedding in Renal and Cardiac Transplant Recipients: Relationship to Immunosuppressive Therapy, Serologic Responses, and the Risk of Posttransplant Lymphoproliferative Disorder (1992)

Epstein-Barr virus (EBV) infection plays a major role in the pathogenesis of posttransplant lymphoproliferative disorder (PTLD). Quantitative oropharyngeal EBV shedding measured by a DNA-DNA dot blot assay and the genotype of isolates determined by a polymerase chain reaction assay were studied in 23 renal and 23 cardiac transplant recipients followed over the first posttransplant year. Five patients developed PTLD and two additional PTLD renal transplant recipients were studied from the time of diagnosis. Significantly higher levels of EBV were observed in primary versus reactivation infection (P < .04) when sequential courses of antilymphocyte globulins or > 4 g of methylprednisolone were used in the first 6 months after transplant and in patients with versus those without PTLD (P < .04), although the former group had a high incidence of primary infection. Patients with the highest EBV shedding had the poorest serologic responses. All PTLD patients shed EBV-1, which was also shed by patients without PTLD.
Mechanical Performance of Diffusion Bonded 316 Stainless Steel for Use in a Hybrid Compact Heat Exchanger (2021)

Presented by NETL at TMS Annual Meeting 2020, 02/20
Novel pharmacotherapy for burn wounds: what are the advancements (2018)

Advancements in personalized and molecular medicine will make an impact on burn therapy. Similarities between severe burns and other critically ill patients will lead to cross-fertilization between different medical specialties. Furthermore, advances in stem cells and tissue regeneration will lead to improved healing and less lifelong disability. Indeed, research in new drug therapy for burns is actively progressing for many different complications.
Asphaltene Molecular-Mass Distribution Determined by Two-Step Laser Mass Spectrometry (2008)

Two-step laser mass spectrometry (L2MS) is explored as a technique to measure the molecular-mass distribution of asphaltenes. Unlike widely used laser desorption/ionization (LDI) mass spectrometry, in which a single laser pulse is used to desorb and ionize asphaltenes, L2MS involves two laser pulses and spatially and temporally separates the desorption and ionization events. This process allows L2MS to measure the asphaltene molecular-mass distribution free from artifacts resulting from aggregation and insufficient laser power, as occur in LDI. Studies of relevant model compounds show that L2MS detects these molecules without aggregation (unlike LDI), with only a minimum of fragmentation/multiple charging, and with relatively uniform sensitivity across the relevant mass range; however, the efficiency of the resonant ionization process is sensitive to molecular structure. These data suggest that L2MS does not suffer from significant mass discrimination in the relevant mass range and that L2MS provides a slight underestimate of the asphaltene molecular-mass distribution. Petroleum asphaltenes from different geographical origins are found to have similar mass spectra, all showing a peak at every nominal mass under an envelope beginning at 200 units, peaking at 500−600 units, and extending to 1000−1500 units. Coal asphaltenes are found to be considerably lighter and less complex, showing pronounced clusters of peaks separated by 14 units under an envelope beginning at 200 units, peaking at 300 units, and extending to 500 units. These results bring the molecular-mass distribution of asphaltenes as measured by laser desorption mass spectrometry in accordance with many other mass spectrometry and diffusion measurements.
Autoradiogram demonstrating proteolytic stability of <sup>3</sup>H labelled peptides in liver microsomes and organ homogenates. (2015)

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;H-D3 was incubated with kidney, brain and liver homogenate for 0, 10, 30, 60, 240 min and 1, 2 days at 37°C and developed on TLC plates. For liver microsomes, the incubation time was 0, 10, 30, 60 and 120 min. Slight difference in Rf values of &lt;sup&gt;3&lt;/sup&gt;H-D3 in liver homogenate might be due to incompletely homogenized liver tissues, which was not observed after incubation with liver microsomes. (Two autoradiograms of liver homogenate were presented in one image and separated through a dashed line.) No obvious proteolytic degradation of D3 can be observed in all the organ homogenates with up to two days’ incubation.&lt;/p&gt;
The Effect of the Photo-Induced Carriers on the Reliability of Oxide TFTs Under Various Intensities of Light (2012)

We investigated the reliability of oxide TFTs under negative gate bias stress combined with various intensities of light having a wavelength of 400 nm. Light illumination caused a considerable <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> shift toward negative direction, as reported in previous works. However, the trapping probability of a single hole is not altered, which means that the basic mechanism of the charge trapping is not changed by light illumination. In oxide TFTs, the hole concentration at the channel and the characteristics of the gate insulator materials are the determinant factors of the reliability under light illumination.
Continuous Infusion of UHMWPE Particles Induces Increased Bone Macrophages and Osteolysis (2010)

Infusion of clinically relevant polyethylene particles, similar to the human scenario, stimulated systemic migration of remotely injected macrophages and local net bone resorption.
In Vivo Magnetic Resonance Imaging of Single‐Walled Carbon Nanohorns by Labeling with Magnetite Nanoparticles (2006)

Nanoparticles of superparamagnetic magnetite have been strongly attached to single-walled carbon nanohorns (SWNHs) by using a simple method, namely the deposition of iron acetate clusters on SWNHs followed by heat treatment. The attached magnetite nanoparticles induce remarkable darkening of the magnetic resonance images, which allowed in vivo visualization (see figure) of the accumulative behavior of SWNHs in the spleen and kidneys. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2006/c2174_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
VERTICAL DENSITY CURRENTS—II1 (1969)

Examples of vertical density currents wholly within the domain of laminar flow, one in a water solution, the other in air, have come to my attention. Both examples illustrate new ways of introducing and dispersing microscopic particles into static fluids and both demonstrate that a stable, clearly defined layer of dispersed particles forms first and that the vertical density currents originate and flow from the lower part of this layer. The new information comes from wholly unrelated lines of research, one in virology, and the other in mycology. Neither investigation was aimed at hydrodynamics yet both provide good experimental support for vertical density currents.
Visible photonic switch based on tunable 2D ferromagnetic photonic crystal (2006)

The aim of the paper is to propose an idea of photonic switch using 2D magnetic photonic crystal (Magneto-PC) structures, which is made of ferromagnetic material. The photonic switch is controlled by an external magnetic field under two magnetization conditions in the hysteresis curve: (1) the saturation magnetization (labeled as the Bs point in the hysteresis curve); and (2) non-magnetization state (labeled as the Hc point in the hysteresis curve). The design of the 2D Magneto-PC consists of three rows of one dimensional array of ferromagnetic rods, called the "3-by-N structure". The variations in the transmission rate and the reflection rate at wavelength 650 nm for the TE and the TM waves, respectively, under these two magnetization conditions in the ferromagnetic hysteresis curve were observed. The simulation is carried out by the finite-difference time-domain (FDTD) method.
Initial operation of an ultra-compact, low voltage Reltron microwave source (2001)

This paper presents, in detail, the design and initial operating characteristics of an ultra-compact, low voltage Reltron source. This device was custom built by Titan/PSI for the University of New Mexico. The initial motivation for developing such a source was for use in a graduate-level pulsed power and plasma science laboratory course. The low voltage compact nature of the system, packaged in a "turn-key" system, makes it an ideal source for studying the basic operating principles of a commercial Reltron high power microwave (HPM) source. Whereas the source preserves the fundamental operating characteristics of a Reltron (including the novel post-acceleration gap feature) the low voltage driver (on the order of 100 kV) limits the microwave power levels that are generated. We will present the cold test results of the cavity, pulsed power characteristics of the driver, as well as results of computer simulations of the source using MAGIC. We will also discuss possible applications of this ultra-compact source.
Development of Fluorescently Labeled, Functional Type I Collagen Molecules (2021)

While de novo collagen fibril formation is well-studied, there are few investigations into the growth and remodeling of extant fibrils, where molecular collagen incorporation into and erosion from the fibril surface must delicately balance during fibril growth and remodeling. Observing molecule/fibril interactions is difficult, requiring the tracking of molecular dynamics while, at the same time, minimizing the effect of the observation on fibril structure and assembly. To address the observation-interference problem, exogenous collagen molecules are tagged with small fluorophores and the fibrillogenesis kinetics of labeled collagen molecules as well as the structure and network morphology of assembled fibrils are examined. While excessive labeling significantly disturbs fibrillogenesis kinetics and network morphology of assembled fibrils, adding less than ≈1.2 labels per collagen molecule preserves these characteristics. Applications of the functional, labeled collagen probe are demonstrated in both cellular and acellular systems. The functional, labeled collagen associates strongly with native fibrils and when added to an in vitro model of corneal stromal development at low concentration, the labeled collagen is incorporated into a fine extracellular matrix (ECM) network associated with the cells within 24 h.
The TILDE naming system (1986)

Article Free Access Share on The TILDE naming system: an experiment in relative naming Authors: Douglas Comer Purdue University, West Lafayette, IN Purdue University, West Lafayette, INView Profile , Ralph E. Droms Purdue University, West Lafayette, IN Purdue University, West Lafayette, INView Profile Authors Info & Claims EW 2: Proceedings of the 2nd workshop on Making distributed systems workSeptember 1986 Pages 1–4https://doi.org/10.1145/503956.503972Online:08 September 1986Publication History 0citation193DownloadsMetricsTotal Citations0Total Downloads193Last 12 Months1Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Geometry-constrained coronary arteries motion estimation from 2D angiograms - Application to injection side recognition (2011)

This paper deals with the 2D motion estimation of coronary arteries. It exploits the geometry of acquisition to strongly constrain the problem, thereby ensuring smooth and robust motion fields. The main contribution of this paper is to formally associate the C-arm angulation from which the heart is observed to the expected parametric motion field. Once this learning phase performed, every new sequence is associated to a fixed motion model, known up to a scale and an origin. The quality of the extracted velocities is visually evaluated over a large representative database. We also present an application of our approach to the motion-based classification of an angiographic exam into right or left artery tree.