gebhart/patrepeval huggingface dataset:
Rules of Stereoselectivity in Tandem Oxidative Polycyclization Reaction with Rhenium(VII) Oxides (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTRules of Stereoselectivity in Tandem Oxidative Polycyclization Reaction with Rhenium(VII) OxidesSantosh C. Sinha, Ehud Keinan, and Subhash C. SinhaView Author Information Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, California 92037 Department of Chemistry, Technion-Israel Institute of Technology, Technion City, Haifa 32000, Israel Cite this: J. Am. Chem. Soc. 1998, 120, 35, 9076–9077Publication Date (Web):August 20, 1998Publication History Received17 April 1998Published online20 August 1998Published inissue 1 September 1998https://pubs.acs.org/doi/10.1021/ja981324ehttps://doi.org/10.1021/ja981324erapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views273Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Alcohols,Cyclization,Oxidation reactions,Oxidative cyclization,Transition states Get e-Alerts
Blood dolichol in lysosomal diseases (1992)

Highly elevated serum total dolichol (free dolichol + dolichyl ester) concentrations have recently been found in two lysosomal storage diseases, aspartylglucosaminuria (AGU) and mannosidosis. The present study demonstrates that the increase of serum dolichol in AGU patients is caused by an increase of serum free dolichol. In 15 patients the mean serum level of free dolichol (227 +/- 16 ng/mL) was 1.9 times higher (p < 0.001) than that in healthy controls (120 +/- 6 ng/mL), while the amounts of dolichol fatty acid esters were similar in the patients and controls (110 +/- 9 vs. 118 +/- 6 ng/mL). In contrast, 10 patients with neuronal ceroid-lipofuscinosis (NCL) (three with infantile, four with juvenile, and three with variant late infantile NCL) had significantly (p < 0.01) lower mean serum levels of both free (79 +/- 5 ng/mL) and total (159 +/- 6 ng/mL) dolichol than age-adjusted healthy controls (free, 100 +/- 6 ng/mL; total, 206 +/- 14 ng/mL). Decreased blood dolichol has not been reported earlier for any other disease. We conclude that the increased serum free dolichol in AGU reflects disturbed lysosomal function and that the decreased free and esterified dolichols in NCLs speak against their presumed primary lysosomal nature.
Diameter-Controlled Carbon Nanotubes Grown from Lithographically Defined Nanoparticles (2004)

We report the novel synthesis method of iron nanoparticles that can easily control both position and diameter significantly smaller than the lithography limit, and also demonstrate diameter- and position-controlled carbon nanotube (CNT) growth from the nanoparticles. We patterned iron particles having a 1.7 ±0.6 nm diameter distribution within a positioning accuracy of ±5 nm by means of the "lithographically-anchored nanoparticle synthesis (LANS)" method. CNTs were grown by chemical vapor deposition using ethanol. A catalyst activity of ∼10% and a CNT diameter distribution of 1.3 ±0.4 nm were obtained. Raman spectroscopy revealed the presence of single-walled CNTs.
Evidence that type II 5'-deiodinase is not a selenoprotein (1991)

Brain type II 5'-iodothyronine deiodinase and liver type I 5'-iodothyronine deiodinase activities are decreased in rats fed a Se(2+)-deficient diet suggesting that both enzymes are Se(2+)-dependent proteins. Since serum thyroxine (T4) concentrations are twice normal in the Se(2+)-deficient animals, it is unclear whether the Se2+ deficiency or the increased circulating T4 account for the decrease in the brain enzyme. In order to separate these two possibilities, the effects of Se2+ on 5'-deiodinase in glial cells (type II) and LLC-PK1 cells (type I) were examined. LLC-PK1 and glial cells were grown in serum-free defined medium containing 0, 1 pM, 10 nM, and 40 nM Se2+ for 3-5 days or in medium containing 75Se2+ for 24 h. Deiodinase isozymes were determined by measuring catalytic activity and by quantification of the BrAc[125I]T4 affinity-labeled substrate binding subunits. Se2+ deficiency was confirmed by measuring the activity of the selenoprotein, glutathione peroxidase. Se2+ caused a concentration-dependent increase in glutathione peroxidase activity in both cell types, as well as in the type I enzyme, but had no effect on the type II enzyme. LLC-PK1 cells contained multiple 75Se(2+)-labeled proteins including the 27-kDa substrate binding subunit of the type I 5'-deiodinase. Glial cells contained seven 75Se(2+)-labeled proteins ranging in size from 12 to 62 kDa, none of which corresponded to the type II substrate binding subunit. these data show that, unlike the type I enzyme, the type II enzyme does not contain a selenocysteine or selenomethionine, further emphasizing the differences between these two isozymes.
Change in Cerebral Blood Flow Velocity with Onset of EEG Silence during Inhalation Anesthesia in Humans: Evidence of Flow-Metabolism Coupling? (1995)

In eight subjects anesthetized with moderate to high doses of inhalation anesthetics (isoflurane or desflurane) during normocapnia, the onset of electrical silence in EEG was associated with a sudden reduction of blood flow velocity monitored from the middle cerebral artery. The magnitude of this reduction was 38 +/- 11% (mean +/- SD; range 24-44%). The change in EEG always preceded the change in flow velocity by 5-7 s. These observations suggest that some flow-metabolism coupling mechanism is preserved during inhalation anesthesia in humans.
Types of Variation (2006)

This volume interfaces three fields of linguistics rarely discussed in the same context. Its underlying theme is linguistic variation, and the ways in which historical linguists and dialectologists may learn from insights offered by typology, and vice versa . The aim of the contributions is to raise the awareness of these linguistic subdisciplines of each other and to encourage their cross-fertilization to their mutual benefit. If linguistic typology is to unify the study of all types of linguistic variation, this variation, both diatopic and diachronic, will enrich typological research itself. With the aim of capturing the relevant dimensions of variation, the studies in this volume make use of new methodologies, including electronic corpora and databases, which enable cross- and intralinguistic comparisons dialectally and across time. Based on original research and unified by an innovative theme, the volume will be of interest to both students and teachers of linguistics and Germanic languages.
Poly(Limonene Thioether) Scaffold for Tissue Engineering (2016)

A photocurable thiol-ene network polymer, poly(limonene thioether) (PLT32o), is synthesized, characterized, fabricated into tissue engineering scaffolds, and demonstrated in vitro and in vivo. Micromolded PLT32o grids exhibit compliant, elastomeric mechanical behavior similar to grids made of poly(glycerol sebacate) (PGS), an established biomaterial. Multilayered PL32o scaffolds with regular, geometrically defined pore architectures support heart cell seeding and culture in a manner similar to multilayered PGS scaffolds. Subcutaneous implantation of multilayered PLT32o scaffolds with cultured heart cells provides long-term 3D structural support and retains the exogenous cells, whereas PGS scaffolds lose both their structural integrity and the exogenous cells over 31 d in vivo. PLT32o membrane implants retain their dry mass, whereas PGS implants lose 70 percent of their dry mass by day 31. Macrophages are initially recruited to PLT32o and PGS membrane implants but are no longer present by day 31. Facile synthesis and processing in combination with the capability to support heart cells in vitro and in vivo suggest that PLT32o can offer advantages for tissue engineering applications where prolonged in vivo maintenance of 3D structural integrity and elastomeric mechanical behavior are required.
700 HYPERTENSIVE RETINOPATHY AND RISK OF CHRONIC KIDNEY DISEASE IN A MULTI-ETHNIC ASIAN POPULATION (2012)

Purpose: To examine the relationship between hypertensive retinopathy signs and risk of chronic kidney disease (CKD) in a multi-ethnic Asian population. Methods: We conducted a prospective, population-based study in a multi-ethnic Asian population, comprising of 4018 Malays, 2408 Chinese, 704 Indians aged 24-95 years. Hypertensive retinopathy signs were measured using qualitative (e.g., retinopathy) and quantitative methods (e.g. retinal vessel calibre) from baseline retinal photographs according to standardized protocols and computer-assisted software. Incident CKD was defined as newly diagnosed clinical CKD stage 5 documented by National Registry of Diseases Office after the baseline examination. Cox regression analysis was performed for assessing the risk of CKD associated with retinal microvascular signs. Results: A total of 7130 participants were free of CKD at baseline, of which 6892(96.7%) had complete information on incident CKD events, retinal microvascular and systemic measurements. During a median follow-up of 4.3 years, 33 (0.5%) participants developed stage 5 CKD. After controlling for age, gender, ethnicity, systolic blood pressure, diabetes, smoking, total cholesterol and high-density-lipoprotein cholesterol, persons with retinopathy signs (hazards ratio [HR] 3.76; 95%CI 1.79–7.94] and retinal arteriolar narrowing (HR 1.53, 95%CI 1.06–2.19, per standard deviation decrease) had a higher risk of CKD. These associations were similar in persons with and without hypertension, and among the three ethnic groups. Conclusion: Hypertensive retinopathy signs are associated with an increased risk of CKD independent of traditional risk factors.
Information Intrinsic Geometric Flows (2006)

Geometric Flow Theory is cross fertilized by diverse elements coming from Pure Mathematic and Mathematical Physic, but its foundation is mainly based on Riemannian Geometry, as explained by M. Berger in a recent panoramic view of this discipline, its extension to complex manifolds, the Erich Kähler’s Geometry, vaunted for its unabated vitality by J.P. Bourguignon, and Minimal Surface Theory. This paper would like to initiate seminal studies for applying intrinsic geometric flows in the framework of information geometry theory. More specifically, after having introduced Information metric deduced for Complex Auto‐Regressive (CAR) models from Fisher Matrix (Siegel Metric and Hyper‐Abelian Metric from Entropic Kähler Potential), we study asymptotic behavior of reflection coefficients of CAR models driven by intrinsic Information geometric Kähler‐Ricci and Calabi flows. These Information geometric flows can be used in different contexts to define distance between CAR models interpreted as geodesics of Entropy Manifold. We conclude with potential application of Intrinsic Geometric Flow on Gauss Map to transform Manifold of any dimension by mean of Generalized Weierstrass Formula introduced by Kenmotsu that can represent arbitrary surfaces with non‐vanishing mean curvature in terms of the mean curvature function and the Gauss map. One of the advantages of the generalized formulae is that they allow to construct a new class of deformations of surfaces by use of Intrinsic Geometric Flow on Gauss Map. We conclude with the Heat equation interpretation in the framework of Information Geometry.
Release Profiles of Tricalcium Phosphate Nanoparticles from Poly(L‐lactic acid) Electrospun Scaffolds with Single Component, Core–Sheath, or Porous Fiber Morphologies: Effects on hASC Viability and Osteogenic Differentiation (2012)

Functional PLA scaffolds are created with single component, core-sheath, or porous fiber morphology and doped with TCP nanoparticles to study the release profiles for use in bone tissue engineering applications. Pharmacokinetic analyses are performed for the three different nanofibrous structures after doping with TCP. Results indicate that single component and porous fiber scaffolds exhibit an initial-burst release profile whereas core-sheath fibers show a steady release. All scaffolds are then seeded with human adipose-derived stem cells (hASC), which remain viable and continue proliferation on all nanofibrous morphologies for up to 21 d. Osteogenic differentiation of hASC and cell-mediated calcium accretion are largest on porous fibers.
Increased-bandwidth, meandering vibration energy harvester (2011)

This paper details how a distributed proof mass can be used to achieve an increased operational bandwidth in a low-frequency, meandering piezoelectric vibration energy harvester. The fabricated device features two closely spaced resonant modes at 33 Hz and 43.3 Hz with measured RMS output powers of 107.3 μW and 74.9 μW, respectively, at a peak acceleration magnitude of 0.2 g. The output power of this system remains above 25 μW in the frequency band from 32.3 Hz up to 45 Hz. The increased bandwidth is enabled by the unique frequency response characteristics of the coupled system.
Semiring Pruning for Information Dissemination in Mobile Ad Hoc Networks (2009)

Link state routing mechanisms have shown good convergence behaviour in networks with mobile hosts. Compared to traditional link state mechanisms, which suffer from broadcast storm problems in mobile ad hoc networks (MANETs), pruned link state approaches such as those used in optimized link state routing (OLSR) have shown significant reduction in the control overhead. In this paper, we show that the pruning function is a fundamental component of link state routing protocols for MANETs, and develop a class of pruning methods for many commonly used routing objectives. We show that the ability of our local pruning methods to preserve optimal paths is a special case of the semiring distribution property.
Quantum Machine Learning for Ocular Disease Recognition (2023)

In this paper we use quantum machine learning to detect and classify ocular diseases across age related macular degradation, cataract, diabetic, glaucoma, hypertension, and patological myopia categories versus a control group. We analyze fundus imagery from 1000 patients. Early findings indicate there may be benefit in terms of accuracy and loss function minimization of 2.07% and 1.979x respectively compared to a similar method implemented using traditional computers.
JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate (2021)

The discovery of a novel 2-aminotetrahydropyridine class of BACE1 inhibitors is described. Their pK<sub>a</sub> and lipophilicity were modulated by a pending sulfonyl group, while good permeability and brain penetration were achieved via intramolecular hydrogen bonding. BACE1 selectivity over BACE2 was achieved in the S3 pocket by a novel bicyclic ring system. An optimization addressing reactive metabolite formation, cardiovascular safety, and CNS toxicity is described, leading to the clinical candidate JNJ-67569762 (<b>12</b>), which gave robust dose-dependent BACE1-mediated amyloid β lowering without showing BACE2-dependent hair depigmentation in preclinical models. We show that <b>12</b> has a favorable projected human dose and PK and hence presented us with an opportunity to test a highly selective BACE1 inhibitor in humans. However, <b>12</b> was found to have a QT effect upon repeat dosing in dogs and its development was halted in favor of other selective leads, which will be reported in the future.
A Method for Power Amplifier Distortions Compensation at the RX Side for the 5G NR Communication Systems (2022)

For the past years, the Internet of Things (IoT) supported by 5G technology, has been expanding rapidly across a wide range of services, enabling inter-object connectivity for the automotive industry, consumer electronics, transportation, logistics sectors, and manufacturing. With the increasing ubiquitous usage of various small-sized sensors, manufacturing cost of each element taken remains a critical aspect. Relatively low price of individual elements is the key for enabling tightly connected environment, but may severely affect RF chains quality as well as overall performance. With 5G expansion to the sub-THz bands, power amplifier nonlinearity may significantly limit system performance even in high- grade devices, due to power amplifier design limitations. Multiple studies were done to mitigate nonlinearity impact, both at the transmitter (TX) and receiver (RX) sides. Many solutions propose for evaluation and further compensation of the PA nonlinearity effects, via decision-directed feedback, training or even statistical processing of the received signal. However, with knowledge of the PA nonlinearity function at the receiver side, the processing may be simplified by the application of the reverse function to the equivalent signal in the time domain. In this paper we propose a method for PA nonlinear distortion compensation at the RX side, which can be adjusted for several signal waveforms adopted in 5G NR (New Radio) standard, such as CP-OFDM, DFT-S-OFDM, and others. The simulation results presented demonstrate performance improvement both for the sub-THz PA models and models for the 30–70 GHz band.
The Marriage of Modeling and GIS (2003)

Since the introduction of computers, hydraulic analysis models and Geographical Information Systems (GIS) have been evolving and becoming more powerful. In recent years, the two technologies have become more highly integrated than ever as each generation of new software makes this integration easier. Explaining how modeling and GIS interact is lot like the story of the blind men trying to explain what an elephant looks like. There is no single correct way to link models with GIS. This paper will put into perspective the ways in which modeling and GIS can work together and discuss some issues that users must consider in making the best use of both technologies.
ChemInform Abstract: PHOTOCYCLOADDITIONS TO 3‐PHENYL‐1,2‐BENZISOTHIAZOLE (1981)

Abstract Aus den 1,2‐Benzisothiazolen (I) erhält man mit den Acetylenen (II) die Addukte (III), die sich thermisch zu den bicyclischen Derivaten (IV) umlagern.
Transcriptional repression of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 gene mediated by cis elements present in the 3'-untranslated region. (1997)

The cyclin-dependent kinase inhibitor p21WAF1/CIP1 plays a major role in the induction of G1 cell cycle arrest following DNA damage and is known to be regulated by p53-dependent and -independent pathways. Here, we show that p21WAF1/CIP1 transcription is also regulated, independently of p53, by the cis elements that are located downstream of the transcription start site. A cDNA fragment of approximately 180 bp, located 260 bases 3' to the translation termination codon of p21WAF1/CIP1 cDNA, was cloned in both the sense and antisense orientations downstream of the CMV promoter, upstream of the SV40 promoter, and both upstream and downstream of the p21WAF1/CIP1 promoter in the plasmids carrying the luciferase reporter gene. The constructs were transiently transfected in human breast carcinoma cells MCF-7 and MDA-MB-468 and a Syrian hamster smooth muscle cell line DDT1MF2 and were found to elicit 2-3-fold or higher repression of luciferase activities. By using overlapping deletions of the above 180-bp fragment, we identified a 48-bp subfragment that contains putative cis element(s) that participate in the transcriptional repression of the p21WAF1/CIP1 gene. The overlapping subfragments bind, in vitro, to specific proteins present in the nuclear extracts of MDA-MB-468 and DDT1MF2 cells. We, therefore, propose that additional mechanism(s) exist that regulate expression of the cellular p21WAF1/CIP1 and may contribute to p21WAF1/CIP1-dependent control of the cell cycle.
A Robust Machine Learning Method for Cell-Load Approximation in Wireless Networks (2018)

We propose a learning algorithm for cell-load approximation in wireless networks. The proposed algorithm is robust in the sense that it is designed to cope with the uncertainty arising from a small number of training samples. This scenario is highly relevant in wireless networks where training has to be performed on short time scales because of a fast time-varying communication environment. The first part of this work studies the set of feasible rates and shows that this set is compact. We then prove that the mapping relating a feasible rate vector to the unique fixed point of the non-linear cell-load mapping is monotone and uniformly continuous. Utilizing these properties, we apply an approximation framework that achieves the best worst-case performance. Furthermore, the approximation preserves the monotonicity and continuity properties. Simulations show that the proposed method exhibits better robustness and accuracy for small training sets in comparison with standard approximation techniques for multivariate data.
Prototyping a query compiler using Coq (experience report) (2017)

Designing and prototyping new features is important in many industrial projects. Functional programming and formal verification tools can prove valuable for that purpose, but lead to challenges when integrating with existing product code or when planning technology transfer. This article reports on our experience using the Coq proof assistant as a prototyping environment for building a query compiler intended for use in IBM's ODM Insights product. We discuss the pros and cons of using Coq for this purpose and describe our methodology for porting the compiler to Java, as required for product integration.
Compression of Ti3Si0.5Ge0.5C2 to 53 GPa (2004)

Using a synchrotron radiation source and a diamond anvil cell, we measured the pressure dependence of the lattice parameters of a polycrystalline Ti3Si0.5Ge0.5C2 sample. Up to a pressure of 53 GPa, no phase transformations were observed. As for the isostructural hexagonal Ti3SiC2, the compressibility along the c axis was greater than along a. The bulk modulus is 183±4 GPa with a pressure derivative of 3.4±0.2. This work shows that the replacement of Si by Ge in Ti3SiC2 results in a systematic decrease in the bulk moduli.
Preparation of N‐Hydroxysuccinimido esters via Palladium‐Catalyzed Carbonylation of Aryl Triflates and Halides. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Robust Energy-Efficient Adder Topologies (2007)

In this paper we explore the relationship between adder topology and energy efficiency. We compare the energy-delay tradeoff curves of selected 32- bit adder topologies, to determine how architectural features and design techniques affect energy efficiency. Optimizing different adders for the supply and threshold voltages, and transistor sizing, we show that topologies with the least number of logic stages having an average fanin of two per stage, and fewest wires are most energy efficient. While a design with fully custom sizes can be extremely tedious to layout, we show that custom sizing can be used as a guide to group different gates in the design, resulting in a manageable layout overhead without significant loss of energy efficiency.