gebhart/patrepeval huggingface dataset:
Cross-lingual sentence extraction for information distillation (2008)

Information distillation aims to analyze and interpret large volumes of speech and text archives in multiple languages and produce structured information of interest to the user. In this work, we investigate cross-lingual information distillation, where nonEnglish (source language) documents are searched for user queries that are in English (target language). We propose to perform distillation both on the original source language data and their English translations output by machine translation, and combine the two outputs. We experimentally show that combination approach results in 8% to 16% absolute (13% to 31% relative) F-measure improvement over the previous work.
Adhesion of an elastic plate to a sphere (2008)

Stationary principles and the von Kármán plate theory are used to study the adhesion of thin elastic plates to a rigid sphere. Contact requires both flexural and membrane strains that can lead to partial or complete delamination. Interestingly, whereas a large area plate might spontaneously delaminate from the sphere, dividing this plate into many smaller plates with equivalent thickness eliminates membrane strains and may allow complete contact. The theoretical predictions are compared to experimental results for low density polyethylene on a smooth glass sphere. The peel strength is estimated with a modified Kendall peel equation.
La Société européenne de virologie vétérinaire : bilan et perspectives (2004)

Jestin André. La Société européenne de virologie vétérinaire : bilan et perspectives. In: Bulletin de l'Académie Vétérinaire de France tome 157 n°3, 2004. pp. 75-77.
6-Deoxy-8-O-methylrabelomycin and 8-O-methylrabelomycin from a Streptomyces species. (1988)

In the course of our screening for new antibiotic, newmembersof benz[a]anthraquinone antibiotics (I and II), which showed antibacterial activity against Gram-positive bacteria were isolated from a culture broth of Streptomyces tsusimaensis MI310-38F7. This strain produced nonactin and a minor yellow compound (III) which was identical with X-14881 E1}. This report describes the isolation, characterization and structure determination of these compounds, named 6-deoxy-8-0-methylrabelomycin (I) and 8-0-methylrabelomycin (II).
Developing a High Volume Manufacturing Wet Clean Process to Remove BF<sub>2</sub> Implant Induced Molybdenum Contamination (2009)

This work details the investigation of potential problems in Complimentary BiCMOS technology, especially PNP transistors arrays. Optical examination of the wafer revealed defects in the P Buried Layer (PBL) areas of the die. Electrical testing correlated these PBL defects to PNP array current leakage. As the PBL module is completed very early on in the process, we devised a shortloop (SL) to reproduce these defects and identify the root cause of current leakage.
Counting methods for cyclic relations (1988)

In this paper we consider selections of the form “column = constant” on relations defined by linear recursive, two rule datalog programs. In general, counting methods perform well on such queries. However, counting methods fail in the presence of cycles in the database. We present an algorithm in the spirit of counting methods that correctly deals with cyclic data and has the same asymptotic running time as counting methods. The algorithm, which is based on reducing a query on a database to a question about intersections of semi-linear sets, works by using efficient methods to construct the appropriate semi-linear sets from the database and query constant.
Demo overview (2014)

Realizing large scale multi-party conference is a challenge today when realtime and high bandwidth multimedia components are involved due to lack of scalability of server and band-width resources. We demonstrate a scalable conference design over the Virtual Service Edge Router (VSER) platform which is an ICN edge service router with the capability of hosting arbitrary realtime and non-realtime services as virtual machines (VM). The platform services are orchestrated through a programmable framework and takes advantage of scalable forwarding plane for content distribution.
Electroactive Self-Assembled Monolayers on Gold via Bipodal Dithiazepane Anchoring Groups (2008)

Novel dithiazepane-functionalized ferrocenyl-phenylethynyl oligomers 1 and 2 have been synthesized. Self-assembled monolayers (SAMs) of these ferrocene derivatives have been studied by X-ray photoelectron spectroscopy, ellipsometry, and cyclic voltammetry. It has been shown by XPS that monolayers of the dithiazepane-anchored molecules on gold electrodes contain gold-thiolate species. Cyclic voltammetry of the SAMs were characteristic of stable electroactive monolayers even for single-component SAMs of 1 and 2, with the more ideal responses recorded for the two-component SAMs diluted with undecanethiol. The small variation in peak splittings at progressively higher scan rates in these SAMs makes dithiazepane-bridged redox species promising candidates for further studies on molecular wires with bipodal anchoring.
Characterization and Electrochemical Properties of Graphene / Silicon Grafted Composite Materials for Applications in Lithium-Ion Battery (2014)

Density and energy performance of Li -ion batteries are highly dependent on the physical and chemical properties of the electrode materials. The negative electrode materials still offer a large area to explore to improve both capacity and reversibility for lithium storage. In this context, the development of negative electrodes based on silicon has led to numerous researches (1). The high specific capacitance of silicon (3850 mAh.g -1 ) is the main asset for the use of this material. However, silicon has major drawbacks (volume expansion, irreversible formation of LixSiy alloys,... ) that cause early degradation of the electrodes. The approach developed in our laboratory is to link the two components by a chemical bond (covalent) between the two materials. This covalent bond, resulting from a chemical grafting of a diazonium salt (4-aminoaniline) allows linking the carbon particles to silicon nanoparticles via a phenyl bridge. This technique has been used to bond silicon nanoparticles to carbon nanotubes (2) which helped to improve the stability of the electrodes during galvanostatic cycling. The work presented here focuses on a coupling between silicon nanoparticles and graphene sheets. Graphene is potentially interesting for Li-ion batteries applications, it has good electronic conductivity and its layered structure could promote an increase in the strength of the electrodes. The sheets can act as a buffer when the silicon particles volume increases, thereby helping to maintain the cohesion of the electrode during different cycles of charge and discharge (3). The graphene synthesis was performed according to the Hummers method and leads to particles whose specific surface area is about 200 m² /g (Figure 1). Electrode materials were characterized by different techniques (TGA-MS, BET, SEM, IR / Raman spectroscopy, cyclic voltammetry, galvanostatic cycles ...) at different stages (graphene modification, graphene / silicon coupling) to show the presence of molecular bridges and determine their influence on the electrochemical behavior of a Li-ion battery. Performance measured 0.16A.g -1 (Figure 2) clearly show a significant improvement in grafted materials compared to a simple mixture of graphene / Silicon materials. Acknowledgments: The authors thank the French National Research Agency (Graf'N'Stock project) for financial support. References (1) M. N. Obrovac, L. Christensen, Electrochem. Solid-State Lett . 7 (2004) A93 (2) C. Martin., O. Crosnier, R. Retoux, D. Bélanger, D. M. Schleich, T. Brousse, Advanced Functional Material 21 (2011) 3524 (3) B. Nguyen, N. Kumar, J. Gaubicher, F. Duclairoir, T. Brousse, O. Crosnier, L. Dubos, G. Bidan, D. Guyomard, B. Lestriez, Adv. Energy, Materials , (2013)3, 1351
Tivozanib mediated inhibition of c-Kit/SCF signaling on Tregs and MDSCs and reversal of tumor induced immune suppression correlates with survival of HCC patients (2020)

The immune modulatory effect of tivozanib, a tyrosine kinase inhibitor, and the underlying immune mechanisms impacting survival of HCC patients have not been investigated. Pre-clinical studies have shown that tivozanib reduces Tregs and MDSCs accumulation through inhibition of c-Kit/SCF axis. We rationalized that c-Kit/SCF axis antagonism by tivozanib may reverse tumor-induced immune suppression in HCC patients. The frequency of circulating Tregs, MDSCs, CTLA-4+Tregs, PD-1+T cells, c-Kit+pERK-2+Tregs, and c-Kit+pERK-2+MDSCs were quantified in HCC patients at baseline and two time points during tivozanib treatment. We report for the first time that reduction in Tregs after tivozanib treatment and increased levels of baseline CD4+PD-1+T cells correlated with significant improvement in overall survival (OS) of the patients and these signatures may be potential biomarkers of prognostic significance. This immune modulation resulted from tivozanib-mediated blockade of c-Kit/SCF signaling, impacting ERK2 phosphorylation on Tregs and MDSCs. Low pre-treatment CD4+T cells: Treg ratio and reduction in the frequencies of Foxp3+c-Kit+pERK+Tregs after tivozanib treatment correlated significantly with progression free survival. In a comparative analysis of tivozanib vs sorafenib treatment in HCC patients, we demonstrate that decrease in the baseline numbers or frequencies of Foxp3+Tregs, MDSCs and exhausted T cells was significantly greater following tivozanib treatment. Additionally, greater increase in CD4+T cell: Treg ratio after tivozanib treatment was associated with significant improvement in OS compared to sorafenib treatment, highlighting the greater efficacy of tivozanib. These insights may help identify patients who likely would benefit from c-Kit/SCF antagonism and inform efforts to improve the efficacy of tivozanib in combination with immunotherapy.
Antigen-specific Vγ2Vδ2 T effector cells confer homeostatic protection against pneumonic plaque lesions (2009)

The possibility that Vgamma2Vdelta2 T effector cells can confer protection against pulmonary infectious diseases has not been tested. We have recently demonstrated that single-dose (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) plus IL-2 treatment can induce prolonged accumulation of Vgamma2Vdelta2 T effector cells in lungs. Here, we show that a delayed HMBPP/IL-2 administration after inhalational Yersinia pestis infection induced marked expansion of Vgamma2Vdelta2 T cells but failed to control extracellular plague bacterial replication/infection. Surprisingly, despite the absence of infection control, expansion of Vgamma2Vdelta2 T cells after HMBPP/IL-2 treatment led to the attenuation of inhalation plague lesions in lungs. Consistently, HMBPP-activated Vgamma2Vdelta2 T cells accumulated and localized in pulmonary interstitials surrounding small blood vessels and airway mucosa in the lung tissues with no or mild plague lesions. These infiltrating Vgamma2Vdelta2 T cells produced FGF-7, a homeostatic mediator against tissue damages. In contrast, control macaques treated with glucose plus IL-2 or glucose alone exhibited severe hemorrhages and necrosis in most lung lobes, with no or very few Vgamma2Vdelta2 T cells detectable in lung tissues. The findings are consist with the paradigm that circulating Vgamma2Vdelta2 T cells can traffic to lungs for homeostatic protection against tissue damages in infection.
Supplementary Data from Graft-versus-Leukemia Antigen CML66 Elicits Coordinated B-Cell and T-Cell Immunity after Donor Lymphocyte Infusion (2023)

Supplementary Data from Graft-versus-Leukemia Antigen CML66 Elicits Coordinated B-Cell and T-Cell Immunity after Donor Lymphocyte Infusion
Eruberin A, a Natural Flavanol Glycoside, Exerts Anti-Fibrotic Action on Pancreatic Stellate Cells (2015)

Our results demonstrated that eruberin A significantly suppressed the expression levels of fibrotic mediators in PSCs, and we suggest that its anti-fibrotic mechanism was associated with an attenuation of the PI3K/AKT/NF-κB signaling pathway.
Synthesis, Characterization, and Cure Chemistry of Renewable Bis(cyanate) Esters Derived from 2-Methoxy-4-Methylphenol (2013)

A series of renewable bis(cyanate) esters have been prepared from bisphenols synthesized by condensation of 2-methoxy-4-methylphenol (creosol) with formaldehyde, acetaldehyde, and propionaldehyde. The cyanate esters have been fully characterized by infrared spectroscopy, (1)H and (13)C NMR spectroscopy, and single crystal X-ray diffraction. These compounds melt from 88 to 143 °C, while cured resins have glass transition temperatures from 219 to 248 °C, water uptake (96 h, 85 °C immersion) in the range of 2.05-3.21%, and wet glass transition temperatures from 174 to 193 °C. These properties suggest that creosol-derived cyanate esters may be useful for a wide variety of military and commercial applications. The cure chemistry of the cyanate esters has been studied with FTIR spectroscopy and differential scanning calorimetry. The results show that cyanate esters with more sterically demanding bridging groups cure more slowly, but also more completely than those with a bridging methylene group. In addition to the structural differences, the purity of the cyanate esters has a significant effect on both the cure chemistry and final Tg of the materials. In some cases, post-cure of the resins at 350 °C resulted in significant decomposition and off-gassing, but cure protocols that terminated at 250-300 °C generated void-free resin pucks without degradation. Thermogravimetric analysis revealed that cured resins were stable up to 400 °C and then rapidly degraded. TGA/FTIR and mass spectrometry results showed that the resins decomposed to phenols, isocyanic acid, and secondary decomposition products, including CO2. Char yields of cured resins under N2 ranged from 27 to 35%, while char yields in air ranged from 8 to 11%. These data suggest that resins of this type may potentially be recycled to parent phenols, creosol, and other alkylated creosols by pyrolysis in the presence of excess water vapor. The ability to synthesize these high temperature resins from a phenol (creosol) that can be derived from lignin, coupled with the potential to recycle the composites, provides a possible route to the production of sustainable, high-performance, thermosetting resins with reduced environmental impact.
In-Cycle Closed Loop Control of the Fuel Injection on a 1-Cylinder Heavy Duty CI-Engine (2010)

The focus of this article is on implementation of real time combustion control by using an FPGA. The feedback used for the controller is the heat release. Due to the desire to avoid using division on the FPGA an alternative way of calculating the polytropic exponent is investigated. When this method is compared against using a constant exponent it shows less fluctuations in regards to cycle to cycle variations when calculating the heat release. A dual injection strategy is used and real time control is implemented on the second fuel injection. The calculated heat release is continuously compared with a reference and then the difference is converted to a duration correction of the fuel injection. This is done by a proportional controller which is initiated after the start of the second injection. By adding a perturbation on the first fuel injection the controller is shown to compensate during the second and thereby decreasing the cycle to cycle variations.
125I Radioimmunoassay for the Dual Detection of Amphetamine and Methamphetamine (1994)

Abstract A radioimmunoassay that exhibits a nearly equivalent response to D-amphetamine and D-methamphetamine in urine over the assay range of 0 to 1000 ng/mL while displaying low cross-reactivity to L-amphetamine and L-methamphetamine (4.6% and 2.4%, respectively) has been developed. In addition, methylenedioxy-amphetamine (MDA) and methylenedioxymethamphetamine (MDMA) were detectable in the assay with cross-reactivity levels of &amp;gt;100% and 77% respectively. Little cross-reactivity was observed with the commonly encountered over-the-counter (OTC) drugs and this cross-reactivity was further reduced by the addition of sodium periodate into the reaction mixture to oxidize the β-hydroxylamines. The double (second) antibody assay uses 125I-radiolabeled derivatives of both D-amphetamine and D-methamphetamine as tracers in combination with two highly specific sheep antisera directed against D-amphetamine and D-methamphetamine. The assay exhibits a dose-response of approximately 90,000 dpm from 0 to 1000 ng/mL of D-amphetamine or D-methamphetamine with a minimum detectable dose for either drug of approximately 25 ng/mL. With a cut-off level of 500 ng/mL, the assay gave a positive result for 100% of the 111 clinical samples containing GC/MS confirmed (at or above the NIDA GC/MS cut-off values) levels of amphetamine and/or methamphetamine. Eighty-eight samples that screened negative in a clinical laboratory were all negative in the assay. Nineteen samples which were incorrectly identified as positive by other commercially available amphetamine assays were negative in this RIA.
Triblock and pentablock terpolymers by sequential base-assisted living cationic copolymerization of functionalized vinyl ethers (2015)

A series of novel, well-defined triblock and pentablock terpolymers of <italic>n</italic>-butyl vinyl ether (nBVE), 2-chloroethyl vinyl ether (CEVE) and <italic>tert</italic>-butyldimethylsilyl ethylene glycol vinyl ether (SiEGVE) were synthesized by sequential base-assisted living cationic polymerization.
Effect of ABC transporters on HIV‐1 infection: inhibition of virus production by the MDR1 transporter (2000)

The MDR1 multidrug transporter P-gp (P-glycoprotein) is an efflux pump that extrudes diverse hydrophobic drugs and peptides from cells. Since the entry of HIV-1 into cells involves an initial interaction of the viral gp41 hydrophobic peptide with the plasma membrane, a potential effect of P-gp on HIV-1 infectivity was explored. Virus production was greatly decreased when P-gp was overexpressed at the surface of a continuous CD4(+) human T-leukemic cell line (12D7) infected with HIV-1(NL4-3), a T-tropic molecular clone of HIV-1. P-gp overexpression did not significantly alter the surface expression or distribution of either the HIV-1 receptor CD4 or the coreceptor CXCR4. Reduction of HIV-1 infectivity in P-gp-expressing cells occurred both during the fusion of viral and plasma membranes and at subsequent step(s) in the HIV-1 life cycle.
Simulations of shock-compressed hydrogen (2000)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation S. R. Bickham, T. Lenosky, L. A. Collins, J. D. Kress; Simulations of shock-compressed hydrogen. AIP Conf. Proc. 18 April 2000; 505 (1): 45–48. https://doi.org/10.1063/1.1303417 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Global convergence analysis of mixed-signal systems (2011)

This paper proposes two practical approaches to address global convergence failures, commonly encountered in mixed-signal systems in which analog and digital components closely interact. That is, a nominally-working system may fail intermittently depending on its initial conditions upon start-up. The first approach uses a data clustering analysis and verifies global convergence with randomly-selected pilot simulations. The second approach adopts the practice of representing indeterminate states with X by defining its equivalent concept for analog based on entropy. With oscillator and phase-locked loop examples, it is demonstrated that the proposed approaches can effectively detect the failures and guide designers where to add more resets to prevent them.
Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization (2022)

The identification of agonists of the stimulator of interferon genes (STING) pathway has been an area of intense research due to their potential to enhance innate immune response and tumor immunogenicity in the context of immuno-oncology therapy. Initial efforts to identify STING agonists focused on the modification of 2',3'-cGAMP (<b>1</b>) (an endogenous STING activator ligand) and other closely related cyclic dinucleotides (CDNs). While these efforts have successfully identified novel CDNs that have progressed into the clinic, their utility is currently limited to patients with solid tumors that STING agonists can be delivered to intratumorally. Herein, we report the discovery of a unique class of non-nucleotide small-molecule STING agonists that demonstrate antitumor activity when dosed intratumorally in a syngeneic mouse model.
Improvement of Targeted Therapy by E. coli Phage-lysate Vaccination: Tumor Microenvironment Modulation and Magnetic Nanoparticle Delivery Enhancement in Tumor Tissue (2023)

BACKGROUND.The tumor microenvironment (TME) has an essential role in cancer development.TME reduces the drug and nanoparticle delivery in tumor tissue and minimizes the treatment outcomes.The new therapeutic strategies of TME reprogramming have shown great promise.One such strategy is TME modulation by the E. coli phage-lysate (EcPHL) vaccination with TME modification and enhancement of magnetic nanoparticles (mNP) uptake by tumor tissue.OBJECTIVES In the current study, we aimed to evaluate the effects of EcPHL vaccination on TME and mNP distribution in the tumor tissue.METHODS Experiments were carried out on 20-25 g BALB/c male mice.EcPHL intraperitoneal vaccinations (0,25 ml, 3x, with 3-day intervals) were initiated after 6 days of the Ehrlich ascites carcinoma (EAC) cells subcutaneous inoculation and intratumoral administration of mNP (5 mg/cm3) -on the 4 th day after the last administration of EcPHL.Tumor volume was measured using a Vernier caliper.Tumor tissue samples, and the spread of mNPs in tumor tissue were estimated using microscope Leica DM6B, Motic Easy Scan Pro scanner (Ultrahigh NA APO 20X [NA 0,75], resolution 40X:0,25 mm/pixel). RESULTSThe mean tumor volume (MTV) was significantly reduced in EcPHL-vaccinated mice.The morphological investigation has shown an increased number of immunocompetent cells, basically macrophages, around the atypical cells in the tumor stroma, infiltrating the inflammatory regions and necrotic areas in the center of the tumor tissue.The inflammatory infiltrations with macrophages were prevalent in the necrotic areas.After mNP injection, the pigment was spread at a distance from the injection site as concentrated masses in extracellular regions of tumor tissue.Areas of inflammatory infiltration and concentration of iron-containing cells were significantly higher in the EcPHL-vaccinated mice compared to unvaccinated, and iron-containing macrophages were detected at a much greater distance from the injection site.CONCLUSIONS EcPHL stimulates anticancer responses, inhibits tumor growth, and enhance the distribution of mNP in tumor tissue.
Hydrogen bonding to oxygen in siloxane bonds drives liquid phase adsorption of primary alcohols in high-silica zeolites (2023)

Upon liquid phase adsorption of C<sub>1</sub>-C<sub>5</sub> primary alcohols on high silica MFI zeolites (Si/Al = 11.5-140), the concentration of adsorbed molecules largely exceeds the concentration of traditional adsorption sites: Brønsted acid and defect sites. Combining quantitative <i>in situ</i><sup>1</sup>H MAS NMR, qualitative multinuclear NMR and IR spectroscopy, hydrogen bonding of the alcohol function to oxygen atoms of the zeolite siloxane bridges (Si-O-Si) was shown to drive the additional adsorption. This mechanism co-exists with chemi- and physi-sorption on Brønsted acid and defect sites and does not exclude cooperative effects from dispersive interactions.