gebhart/patrepeval huggingface dataset:
Study on Leakage Rates of High Temperature Water from Wet-Type Transport Casks for Spent Fuel. (II) Leakage Rates from a Scratch on O-Ring Surface and Narrow Wires Adhering to O-Ring Surface (1997)

A programme for enhancement of fuel burnup has been promoted in Japan as part of the sophistication programme for light water reactors to reduce the fuel cost and the amount of spent fuel. As part of this fuel programme, a new wet-type transport cask has been developed to transport the high burnup fuels efficiently. The purpose of this work is to clarify the margin of safety in the evaluation of the release rate of radioactive materials from the wet-type transport cask into the environment and to establish a practical evaluation method for leakage rates based on leak behaviour of high temperature water from the casks. In this paper, leakage rates of water under high pressures and at high temperatures are investigated from two kinds of leak path model. One is a disc with a scratch on the surface which simulates a defect on the seal surface of the O-ring flange and the other is narrow stainless steel wires installed on the O-ring surface which simulates hair adhering to the O-ring surface. From the results, an evaluation method for the leakage rate of water under high pressure and at high temperature from a non-circular leak path and multiple leak paths is proposed.
Salvage microbiology: opportunities and challenges in the detection of bacterial pathogens following initiation of antimicrobial treatment (2014)

Broad-range 16S ribosomal RNA gene PCR coupled with Sanger sequencing was originally employed by soil scientists and was subsequently adapted for clinical applications. PCR coupled with electrospray ionization mass spectrometry has also progressed from initial applications in the detection of organisms from environmental samples into the clinical realm and has demonstrated promise in detection of pathogens in clinical specimens obtained from patients with suspected infection but negative cultures. We review studies of multiplex PCR, 16S ribosomal RNA gene PCR and sequencing and PCR coupled with electrospray ionization mass spectrometry for detection of bacteria in specimens that were obtained from patients during or after administration of antibiotic treatment, and examine the role of each for assisting in antimicrobial treatment and stewardship efforts. Following an exploration of the available data in this field, we discuss the opportunities that the preliminary investigations reveal, as well as the challenges faced with the implementation of these strategies in clinical practice.
Summary of the 4th Nordic Symposium on Digital Pathology (2017)

The Nordic symposium on digital pathology (NDP) was created to promote knowledge exchange across stakeholders in health care, industry, and academia. In 2016, the 4<sup>th</sup> NDP installment took place in Linköping, Sweden, promoting development and collaboration in digital pathology for the benefit of routine care advances. This article summarizes the symposium, gathering 170 attendees from 13 countries. This summary also contains results from a survey on integrated diagnostics aspects, in particular radiology-pathology collaboration.
Identification of candidate odorant degrading gene/enzyme systems in the antennal transcriptome of Drosophila melanogaster (2014)

The metabolism of volatile signal molecules by odorant degrading enzymes (ODEs) is crucial to the ongoing sensitivity and specificity of chemoreception in various insects, and a few specific esterases, cytochrome P450s, glutathione S-transferases (GSTs) and UDP-glycosyltransferases (UGTs) have previously been implicated in this process. Significant progress has been made in characterizing ODEs in Lepidoptera but very little is known about them in Diptera, including in Drosophila melanogaster, a major insect model. We have therefore carried out a transcriptomic analysis of the antennae of D. melanogaster in order to identify candidate ODEs. Virgin male and female and mated female antennal transcriptomes were determined by RNAseq. As with the Lepidoptera, we found that many esterases, cytochrome P450 enzymes, GSTs and UGTs are expressed in D. melanogaster antennae. As olfactory genes generally show selective expression in the antennae, a comparison to previously published transcriptomes for other tissues has been performed, showing preferential expression in the antennae for one esterase, JHEdup, one cytochrome P450, CYP308a1, and one GST, GSTE4. These largely uncharacterized enzymes are now prime candidates for ODE functions. JHEdup was expressed heterologously and found to have high catalytic activity against a chemically diverse group of known ester odorants for this species. This is a finding consistent with an ODE although it might suggest a general role in clearing several odorants rather than a specific role in clearing a particular odorant. Our findings do not preclude the possibility of odorant degrading functions for other antennally expressed esterases, P450s, GSTs and UGTs but, if so, they suggest that these enzymes also have additional functions in other tissues.
Conformational Switches Involved in Orchestrating the Successive Steps of Group I RNA Splicing (1996)

Group I introns possess a conserved guanosine residue at their 3' end, termed omegaG, that, in the case of the Tetrahymena pre-rRNA, is a major determinant of the second step of splicing. We examined the role of omegaG in self-splicing of the 249-residue group I intron of the Anabaena PCC7120 tRNAleu precursor. Contrary to observations with the Tetrahymena pre-rRNA intron, a mutation that places an adenosine residue at the omega position did not have a severe effect on the second step of splicing; neither 3' splice-site selection nor the rate of the second step was altered. The first step of splicing, however, was now readily reversed. This unexpected effect also resulted from a mutation that altered the nucleoside specificity of the intronic guanosine-binding site. The theme common to these mutations is that reversal of the first step of splicing results when there is not a strong interaction between the guanosine-binding site and the omega residue. This suggests that a major role of omegaG is to compete with the exogenous guanosine molecule added to the intron in the first step of splicing for the single guanosine-binding site of the intron. From these data, we are able to extend the mechanism for the self-splicing reaction of this intron by proposing two distinct conformational changes between the first and second steps of the splicing. The first of these is the exchange of the exogenous nucleoside for the omega nucleoside. This is the equilibrium that we can perturb by mutations at either the omega position or the guanosine-binding site. An additional conformational change then fully activates the intron for the second step of splicing.
Demonstration of 10-Tbit/s Multi-Granularity Optical Cross-Connect Node toward 100-Tbit/s Scalability (2009)

We present the first experimental demonstration of a multi-granularity optical-cross-connect node toward 100-Tbit/s scalability. We successfully show 10.24-Tbit/s throughput with completely error-free operation and an 80-Gbit/s (2 × 40-Gbit/s) optical-virtual-concatenation function between different routes.
Tactical audio and acoustic rendering in biomedical applications (1999)

Complexity of biomedical data requires novel sophisticated analysis and presentation methods. Sonification is used as a new information display in augmented reality systems to overcome problems of existing human-computer interface (e.g., opaque or heavy head-mounted displays, slow computer graphics, etc.). A novel taxonomy of sonification methods and techniques is introduced. We present our experience with tactical audio and acoustic rendering in biomedical applications. Tactical audio as an audio feedback is used as support for precise manual positioning of a surgical instrument in the operating room. Acoustic rendering is applied as an additional information channel and/or warning signal in biomedical signal analysis and data presentation.
Off-axis behavior of an infrared meander-line waveplate (2007)

An infrared meander-line waveplate has been modeled and measured over the 8 to 12 microm spectral band in terms of its differential phase delay, axial ratio of the output polarization ellipse, and power throughput for angles of incidence between 0 degrees and 60 degrees. The study has been performed for planes of incidence parallel and perpendicular to the meander-line axis. The main significance is that the phase delay remains almost unaffected by the angle of incidence. Infrared meander-line retarders can thus be used well beyond the paraxial range as in low-f/# optical systems and in non-normal-incidence applications.
Targeting CD44 Expressed on Neutrophils Inhibits Lung Damage in Abdominal Sepsis (2011)

Neutrophil infiltration is an insidious feature in septic lung injury, although the specific adhesive mechanisms regulating pulmonary recruitment of neutrophils in polymicrobial sepsis remain elusive. The aim of this present study was to define the role of CD44 in sepsis-induced neutrophil infiltration and lung damage. Mice were treated with a monoclonal antibody against CD44 before cecal ligation and puncture (CLP) induction. Edema formation, bronchoalveolar accumulation of neutrophils, myeloperoxidase activity, and macrophage inflammatory protein 2 (MIP-2) levels in the lung were determined after CLP. Expression of Mac-1 and CD44 on neutrophils was quantified by using flow cytometry. In separate experiments, fluorescent-labeled neutrophils coincubated with an anti-CD44 antibody were adoptively transferred to CLP mice. Cecal ligation and puncture triggered clear-cut lung damage characterized by edema formation, neutrophil infiltration, and increased levels of MIP-2 in the lung. Notably, immunoneutralization of CD44 reduced CLP-induced pulmonary accumulation of neutrophils. In addition, functional inhibition of CD44 decreased CLP-induced lung damage and edema. However, formation of MIP-2 in the lung and neutrophil expression of Mac-1 were intact in septic mice pretreated with the anti-CD44 antibody. Adoptive transfer experiments revealed that neutrophil rather than lung CD44 mediates neutrophil accumulation in septic lung injury. Moreover, administration of hyaluronidase had no effect on CLP-induced neutrophil recruitment and tissue damage in the lung. Our data demonstrate that CD44 contributes to pulmonary infiltration of neutrophils and lung damage associated with abdominal sepsis. Thus, these novel findings suggest that CD44 may serve as a target to protect against lung injury in polymicrobial sepsis.
Design of Highly Efficient Broadband Class-E Power Amplifier Using Synthesized Low-Pass Matching Networks (2011)

A new methodology for designing and implementing high-efficiency broadband Class-E power amplifiers (PAs) using high-order low-pass filter-prototype is proposed in this paper. A GaN transistor is used in this work, which is carefully modeled and characterized to prescribe the optimal output impedance for the broadband Class-E operation. A sixth-order low-pass filter-matching network is designed and implemented for the output matching, which provides optimized fundamental and harmonic impedances within an octave bandwidth ( <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$L$</tex></formula> -band). Simulation and experimental results show that an optimal Class-E PA is realized from 1.2 to 2 GHz (50%) with a measured efficiency of 80%–89%, which is the highest reported today for such a bandwidth. An overall PA bandwidth of 0.9–2.2 GHz (84%) is measured with 10–20-W output power, 10–13-dB gain, and 63%–89% efficiency throughout the band. Furthermore, the Class-E PA is characterized through measurements using constant-envelop global system for mobile communications signals, indicating a favorable adjacent channel power ratio from <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">${-}$</tex> </formula> 40 to <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">${-}$</tex> </formula> 50 dBc within the entire bandwidth.
Mercury and beyond: diode-pumped solid state lasers for inertial fusion energy (2000)

We have begun building the 'Mercury' laser system as the first in a series of new generation diode-pumped solid-state lasers for inertial fusion research. Mercury will integrate three key technologies: diodes, crystals, and gas cooling, within a unique laser architecture that is scalable to kilojoule energy levels for fusion energy applications. The primary performance goals include 10 percent electrical efficiencies at 10 Hz and 100J with a 2-10 ns pulse length at 1.047 micrometers wavelength. When completed, Mercury will allow rep-rated target experiments with multiple target chambers for high energy density physics research.
Acute graft-versus-host disease prophylaxis with methotrexate and cyclosporine after busulfan and cyclophosphamide in patients with hematologic malignancies (1993)

The combination of two powerful immunosuppressive agents, methotrexate (MTX) and cyclosporine (CSP), has resulted in a significant decrease in the morbidity and mortality after allogeneic bone marrow transplantation (BMT). However, the additive toxicities from ablative preparative regimens may lead to suboptimal use of this combined immunoprophylaxis. We evaluated the efficacy and feasibility of administering MTX/CSP with busulfan (4 mg/kg/d for 4 days) and cyclophosphamide (50 mg/kg/d for 4 days) (BuCy4) in 101 consecutive patients with hematologic malignancies categorized into high- and low-risk groups receiving HLA-matched marrow grafts. Postgrafting immunosuppression consisted of MTX short course (15 mg/m2 on day 1 and 10 mg/m2 on days 3, 6, and 11) and intravenous CSP (1.5 mg/kg every 12 hours). Eighty-three patients (82.1%) received 100% of MTX calculated dose and 87 (86.1%) achieved a CSP therapeutic level (250 to 600 ng/mL) within a median of 16 days. Seventy-three patients (72.2%) received optimal immunosuppressive therapy comprising a full MTX course and achieving CSP therapeutic concentrations. The Kaplan-Meier estimated incidence of grade II to IV acute graft-versus-host disease (GVHD) was 9.2% for all patients and 5.5% in patients receiving optimal GVHD prophylaxis. Eighty-nine patients (88.2%) survived > or = 100 days posttransplant and 43 (48.3%) developed chronic GVHD, the majority of which were de novo (31 of 43). The estimated incidence of relapse was 28.9% for all patients and 14.8% in the low-risk group, with a median follow-up of 24.5 months. High-risk features and the absence of chronic GVHD were significantly associated with relapse (P = .002 and .036, respectively) in multivariate analyses. Projected disease-free survival at 2 years was 52.3% for all patients and 65.2% in low-risk patients. Disease-free survival was significantly improved in optimally treated patients (P = .03) due to a lower incidence of early deaths from acute GVHD and infectious episodes. In conclusion, optimal delivery of MTX/CSP in association with BuCy4 resulted in a near complete abrogation of acute GVHD in HLA-matched transplants and a significantly improved disease-free survival.
Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development (2020)

Pituitary developmental defects lead to partial or complete hormone deficiency and significant health problems. The majority of cases are sporadic and of unknown cause. We screened 28 patients with pituitary stalk interruption syndrome (PSIS) for mutations in the FAT/DCHS family of protocadherins that have high functional redundancy. We identified seven variants, four of which putatively damaging, in FAT2 and DCHS2 in six patients with pituitary developmental defects recruited through a cohort of patients with mostly ectopic posterior pituitary gland and/or pituitary stalk interruption. All patients had growth hormone deficiency and two presented with multiple hormone deficiencies and small glands. FAT2 and DCHS2 were strongly expressed in the mesenchyme surrounding the normal developing human pituitary. We analyzed Dchs2-/- mouse mutants and identified anterior pituitary hypoplasia and partially penetrant infundibular defects. Overlapping infundibular abnormalities and distinct anterior pituitary morphogenesis defects were observed in Fat4-/- and Dchs1-/- mouse mutants but all animal models displayed normal commitment to the anterior pituitary cell type. Together our data implicate FAT/DCHS protocadherins in normal hypothalamic-pituitary development and identify FAT2 and DCHS2 as candidates underlying pituitary gland developmental defects such as ectopic pituitary gland and/or pituitary stalk interruption.
Supplementary Table 6 from MAP Kinase Pathway Alterations in <i>BRAF</i>-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition (2023)

&lt;p&gt;XLSX file 31K, Coverage and Metrics&lt;/p&gt;
Design and verification of a bit error rate tester in Altera FPGA for optical link developments (2010)

This paper presents a custom bit error rate (BER) tester implementation in an Altera Stratix II GX signal integrity development kit. This BER tester deploys a parallel to serial pseudo random bit sequence (PRBS) generator, a bit and link status error detector and an error logging FIFO. The auto-correlation pattern enables receiver synchronization without specifying protocol at the physical layer. The error logging FIFO records both bit error data and link operation events. The tester's BER and data acquisition functions are utilized in a proton test of a 5 Gbps serializer. Experimental and data analysis results are discussed.
Att bli förd bakom ljuset - En diskursanalys av propagandan i de olympiska rapporterna från år 1936 och 1980 (2014)

Efter varje OS publicerar vardlandets nationella olympiska kommitte ett officiellt dokument om spelen. Min ambition ar att undersoka om, och i sa fall hur, dessa officiella dokument har presenterats ur politisk synvinkel. 

Arbetet har som utgangspunkt de officiella rapporter som vardlandernas nationella olympiska kommitteer skriver efter spelen. Avsikten ar inte att gora en komparativ analys mellan dessa spel, men en del forandringar kommer jag att peka pa. I detta arbete kommer en diskursanalys med fokus pa bade bild och text och hur dessa samspelar att genomforas. 

I bade Berlinrapporten fran 1936 och Moskvarapporten fran 1980 kommer de olika politiska vardegrunderna tydligt fram. I de tva rapporterna, kan man tydligt se att de bada regimerna propagerar for sin egen ideologi, dar bada ledarna vill visa hur bra det egna landet ar.
Framework for Abstraction and Control of TE Networks (ACTN) (2018)

Traffic Engineered networks have a variety of mechanisms to facilitate
the separation of the data plane and control plane. They also have a
range of management and provisioning protocols to configure and
activate resources. These mechanisms represent key
technologies for enabling flexible and dynamic networking. The term
Traffic Engineered network refers to a that uses any
connection-oriented technology under the control of a distributed or
centralized control plane to support dynamic provisioning of end-to-
end connectivity. Abstraction of resources is a technique that
can be applied to a single domain or across multiple domains
to create a single virtualized that is under the control of a
network operator or the customer of the operator that actually owns
the resources. This document provides a framework for
Abstraction and Control of Traffic Engineered Networks (ACTN) to
support virtual services and connectivity services.
Biocatalytic Hydrolysis of 3‐Hydroxyalkanenitriles to 3‐Hydroxyalkanoic Acids (2003)

Abstract Microbial catalysts having a combination of nitrile hydratase and amidase activities had a significantly‐higher specific activity for hydrolysis of 3‐hydroxyalkanenitriles than microbial nitrilase catalysts. Comamonas testosteroni 22–1, Dietzia sp. ADL1 and Comamonas testosteroni 5‐MGAM‐4D nitrile hydratase/amidase biocatalysts each hydrolyzed 3‐hydroxyvaleronitrile to 3‐hydroxyvaleric acid (as the ammonium salt) in 99–100% yields, but in consecutive batch reactions with catalyst recycle, alginate‐immobilized C. testosteroni 5‐MGAM‐4D had superior enzyme stability and volumetric productivity. In a series of 85 consecutive batch reactions with biocatalyst recycle for the production of 1.0 M 3‐hydroxyvaleric acid, the recovered nitrile hydratase and amidase activities in the final reaction were 29% and 40%, respectively, of the initial activities. The catalyst productivity for this series of reactions was 670 g 3‐hydroxyvaleric acid/g dry cell weight (50 g 3‐hydroxyvaleric acid/g biocatalyst bead), and the volumetric productivity of the initial reaction in the series was 44 g 3‐HVA/L/h. Similar results were obtained with alginate‐immobilized C. testosteroni 5‐MGAM‐4D for the hydrolysis of 3‐hydroxybutryonitrile and 3‐hydroxypropionitrile to the corresponding 3‐hydroxyalkanoic acid ammonium salts.
What are the effects of six month personalized endurance training on work ability in middle-aged sedentary women: A randomized controlled trial (2020)

Abstract Background To test the effects of guided endurance training on work ability in middle-aged female hospital workers of various occupations. Methods We randomized 265 healthy, sedentary, middle-aged women (45-65 years) to an endurance training group (EG 210 min/week) or a wait-list control group (CG). At baseline and at 6-month follow-up, we assessed work ability (Work Ability Index [WAI]), physical activity (Freiburger activity questionnaire) and peak oxygen uptake (VO 2peak ) by cardiopulmonary exercise testing. To examine the influence of baseline work ability, participants were divided into poor-moderate (WAI 1, 7-36 points, n=83), good (WAI 2, 37-43 points, n=136) and excellent (WAI 3, 44-49 points, n=46) WAI subgroups. Results Cardiorespiratory fitness improved significantly after 6 months in the EG but not in the CG. The WAI total score increased significantly in the EG (38.3±5.0 to 39.8±4.9 points) but not in the CG (39.4±4.7 to 39.3±4.9 points), with a significant difference between groups (p&lt;0.01). In the EG, only the poor-moderate subgroup (WAI 1, 33.0±2.9 to 36.6±4.8 points, p&lt;0.05) increased the WAI total score, with this increase being significantly higher compared to the good (WAI 2, 40.2±2.1 to, 40.4±3.7 points) and excellent (WAI 3, 45.6±1.5 to 45.7±1.8 points) subgroup. Conclusions A 6-month guided exercise training intervention significantly increases cardiorespiratory fitness with concomitant improvements in work ability in middle-aged previously sedentary hospital employees. Women with low baseline work ability seem to particularly benefit from the intervention, which implies that similar interventions may be particularly beneficial for this group of individuals.