gebhart/patrepeval huggingface dataset:
Effects of vitamin E on mitochondrial dysfunction and asthma features in an experimental allergic murine model (2009)

We showed recently that IL-4 causes mitochondrial dysfunction in allergic asthma. IL-4 is also known to induce 12/15-lipoxygenase (12/15-LOX), a potent candidate molecule in asthma. Because vitamin E (Vit-E) reduces IL-4 and inhibits 12/15-LOX in vitro, here we tested the hypothesis that Vit-E may be effective in restoring key mitochondrial dysfunctions, thus alleviating asthma features in an experimental allergic murine model. Ovalbumin (OVA)-sensitized and challenged male BALB/c mice showed the characteristic features of asthma such as airway hyperresponsiveness (AHR), airway inflammation, and airway remodeling. In addition, these mice showed increase in the expression and metabolites of 12/15-LOX, reduction in the activity and expression of the third subunit of mitochondrial cytochrome-c oxidase, and increased cytochrome c in lung cytosol, which indicate that OVA sensitization and challenge causes mitochondrial dysfunction. Vit-E was administered orally to these mice, and 12/15-LOX expression, key mitochondrial functions, ultrastructural changes of mitochondria in bronchial epithelia, and asthmatic parameters were determined. Vit-E treatment reduced AHR, Th2 response including IL-4, IL-5, IL-13, and OVA-specific IgE, eotaxin, transforming growth factor-beta1, airway inflammation, expression and metabolites of 12/15-LOX in lung cytosol, lipid peroxidation, and nitric oxide metabolites in the lung, restored the activity and expression of the third subunit of cytochrome-c oxidase in lung mitochondria and bronchial epithelia, respectively, reduced the appearance of cytochrome c in lung cytosol, and also restored mitochondrial ultrastructural changes of bronchial epithelia. In summary, these findings show that Vit-E reduces key mitochondrial dysfunctions and alleviates asthmatic features.
2016 IEEE Educational Activities Board Awards (2017)

The 2016 IEEE Educational Activities Board (EAB), chaired by IEEE Educational Activities Vice President S. K. Ramesh, upon the recommendation of the EAB Awards and Recognition Committee (ARC) has named the recipients of the 2016 IEEE EAB Awards. EAB Awards recognize and honor individuals and companies for major contributions to engineering and technical education. Awards are given for meritorious activities in accreditation, continuing education, educational innovation, preuniversity education, service to the IEEE EAB, standards education, employee professional development, and informal education systems, as well as related achievements that advance the practice of engineering and engineering education.
Internal Mammary Node Irradiation in Patients With Node-Positive Early Breast Cancer: Fifteen-Year Results From the Danish Breast Cancer Group Internal Mammary Node Study (2022)

In patients with node-positive early breast cancer treated with IMNI or without IMNI depending on breast cancer laterality, IMNI reduced the risk of distant recurrence and death from breast cancer, thereby improving long-term survival.
Deep Neural Networks as Gaussian Processes (2018)

It has long been known that a single-layer fully-connected neural network with an i.i.d. prior over its parameters is equivalent to a Gaussian process (GP), in the limit of infinite network width. This correspondence enables exact Bayesian inference for infinite width neural networks on regression tasks by means of evaluating the corresponding GP. Recently, kernel functions which mimic multi-layer random neural networks have been developed, but only outside of a Bayesian framework. As such, previous work has not identified that these kernels can be used as covariance functions for GPs and allow fully Bayesian prediction with a deep neural network. 
In this work, we derive the exact equivalence between infinitely wide deep networks and GPs. We further develop a computationally efficient pipeline to compute the covariance function for these GPs. We then use the resulting GPs to perform Bayesian inference for wide deep neural networks on MNIST and CIFAR-10. We observe that trained neural network accuracy approaches that of the corresponding GP with increasing layer width, and that the GP uncertainty is strongly correlated with trained network prediction error. We further find that test performance increases as finite-width trained networks are made wider and more similar to a GP, and thus that GP predictions typically outperform those of finite-width networks. Finally we connect the performance of these GPs to the recent theory of signal propagation in random neural networks.
The breakdown of the Green's function eigenvulue expansion in finite element analysis near a source (1984)

A finite element analysis solution for the normal modes in a rectangular room characterized by a small patch of highly absorptive material on one wall was performed. The authors' previous results for this problem indicated a nonphysical falloff of the sound intensity near the source [J. Acoust. Soc. Am. Suppl. 1 74, S23 (1983)]. The reason for this falloff has been identified as a result of the truncation of the Green's function eigenvalue expansion required by the finite element method. This paper shows that this behavior can be overcome (to a large extent) by performing certain algebraic manipulations on the form of the Green's function prior to truncation. The result is an improved rate of convergence of the Green's function, particularly near the source. A more accurate analysis of the energy flow can then be obtained with a limited number of low-frequency modes. Results obtained with this new approach will be compared with those found in the authors previous work.
Karyotypic diversity and evolution of seven mahseer species (Cyprinidae) from India (2009)

Mahseer is a group of fish species that are well known as food and game fishes. The taxonomy of the mahseer species is confusing owing to the morphological variations and habitat adaptation. Detailed karyomorphological investigations have been carried out in seven species of mahseer, using karyotyping, Ag-NOR and fluorescent staining techniques. The basic diploid chromosome number (2n), in all mahseer species, was observed to be 100; however, the karyotype formula varied among the species, which were recorded as: 20m + 14sm + 22st + 44t (fundamental arm number, FN = 134) in Tor khudree; 22m + 24sm + 24st + 30t (FN = 146) in Tor mussullah; 12m + 22sm + 14st + 52t (FN = 134) in Tor putitora; 20m + 24sm + 24st + 32t (FN = 144) in Tor tor; 20m + 30sm + 24st + 26t (FN = 150) in Tor chelynoides; 20m + 20sm + 20st + 40t (FN = 140) in Tor progeneius; and 20m + 18sm + 14st + 48t (FN = 138) in Neolissochilus hexagonolepis. Silver staining of the chromosomes revealed the presence of multiple nucleolar organizer regions (NOR) in these mahseer species. The highest number of NORs was observed in T. tor (four pairs of chromosomes), whereas the other six species possessed Ag-NOR signals on only two pairs of chromosomes. Although chromomycin A(3) (CMA(3)) staining induced bright fluorescence signals on same Ag-NORs sites, with CMA(3), one additional signal was observed on the p arm of subtelocentric chromosomes in T. tor, T. chelynoides, T. progeneius and N. hexagonolepis, which may indicate the presence of inactive NOR in these species. The information on cytogenetic profile of these mahseer species is discussed in the light of cytotaxonomic implications and understanding the karyoevolution of these fish species.
Twist Form of Teleocidin Derivatives is Active in in vivo Tumor Promotion by (-)-Benzolactam-V8-310. (1998)

Teleocidin derivatives and the core structure, (-)-indolactam-V ((-)-IL-V), adopt two conformations in solution, the "twist" and the "sofa" forms. (-)-Benzolactam-V8-310 ((-)-BL-V8-310), which specifically adopts the twist form in solution, has been reported to have a significant effect on HL-60 cells and protein kinase C affinity. In this paper, we describe the biological activity with regard to tumor promotion on mouse skin and the wide variety of biological activity of (-)-BL-V8-310 and its derivatives. In both twist and sofa forms (-)-BL-V8-310 inhibited specific 3H-12-O-tetradecanoylphorbol-13-acetate (TPA) binding to a particulate fraction of mouse skin more strongly than (-)-IL-V. The doses for 50% inhibition (IC50) of (-)-IL-V, (-)-BL-V8-310, and teleocidin B-4 were 1000, 400 and 12 nM, respectively. As for the induction of tumor necrosis factor-alpha (TNF-alpha) release into the medium from HL-60 cells, the EC200 values, which are the concentrations of the compound required to achieve 200 pg/ml TNF-alpha in the medium, were 1700, 500 and 19 nM for (-)-IL-V, (-)-BL-V8-310 and teleocidin B-4, respectively. The same amounts (5.5 nmol per application) of (-)-BL-V8-310 and teleocidin B-4, induced tumors on mouse skin initiated with 7,12-dimethylbenz(a)anthracene (DMBA) in 13.3% and 86.7% of tumor-bearing mice, respectively, in week 20. These results confirmed that the twist form of teleocidin derivatives is the active form as far as the induction of biological activity is concerned. Also (-)-BL-V8-310 is a new synthetic tumor promoter designed from data obtained using the receptor cavity model of TPA-type tumor promoters.
Formation and Properties of Silk Thin Films (1993)

As an immobilization matrix cast fibroin silk films exhibit useful properties including stability to most solvents, biological compatibility, phase transition for the physical entrapment of reactive molecules, and the capablity to retain high activity of the entrapped molecules. However, in the casting process there is limited control over the density, thickness and the orientation of the polymer chains. The Langmuir-Blodgett (LB) technique can enhance the control of the membrane structure and allow improved control over membrane properties. We have formed natural silk films using the Langmuir technique. Silk fibroin, regenerated from Bombyx mori cocoons, formed stable LB thin films as indicated from pressure/area isotherms. Multiple layers of the silk fibroin were deposited on a number of substrates and basic information about the physical properties of the LB films were obtained with transmission electron microscopy (TEM) and ellipsometry data. Preliminary analysis of electron diffraction data from the film indicates a polycrystalline structure consistent with the known structure of silk. Infrared spectrometric analysis of these silk films using attenuated total reflectance (ATR) gave wavenumbers for amide I, II, III and V bands, which are in agreement with the silk II conformation reported for cast silk membranes.
Diesel Engines Fueled by Wood Pyrolysis Oil: Feasibility and Perspectives (2001)

&lt;div class="htmlview paragraph"&gt;Aim of this paper was to assess the feasibility of the application of wood pyrolysis oil (WPO) as a fuel for medium-duty Diesel engines. The experimental activity was carried out both on a diesel injection system and on a DI Diesel engine. High-speed visualization was used to highlight the spray characteristics and an instrumented test bench to evaluate engine performance and emissions. No modification was carried out on the engine and the efforts were addressed to make the WPO compatible with engine operation. Accordingly, WPO was not tested as a pure fuel, but in blends with diglyme and in emulsions with Diesel fuel.&lt;/div&gt;
Improvement of kink and beam steering characteristics of 0.98-μm GaInAs-GaInP high-power lasers utilizing channel ion implantation (2000)

We demonstrate a kink and beam steering free operation of 0.98-μm GaInAs-GaInP high-power ridge waveguide (RW) lasers utilizing channel ion implantation. The ion-implanted regions along the both sides of the ridge effectively suppressed the excitation of higher order lateral modes, which causes beam steering and kink. The maximum power without beam steering and kink has been achieved over 250 mW for channel ion-implanted RW lasers with 1.8-3.7-μm ridge width, compared to 120-mW maximum power without the channel ion implantation.
A theoretical study of the physiological significance of respiratory sinus arrhythmia (2012)

Respiratory sinus arrhythmia (RSA) is a phenomenon whereby the heart rate increases during inspiration and decreases during expiration. We used mathematical models to test two hypotheses for the physiological function of RSA: 1) a previously suggested hypothesis that RSA improves gas exchange efficiency and 2) a new hypothesis that RSA minimizes the work done by the heart while maintaining physiological levels of arterial carbon dioxide. The study was performed in two parts. First, the optimal heart rate (HR) was calculated using techniques from optimal control theory. Second, the HR function was prescribed and the cardiac work, as well as the volumes of oxygen and carbon dioxide taken up or removed by the blood respectively were calculated. We found that although gas exchange efficiency improved with slow and deep breathing and with increased mean heart rate, this was unrelated to RSA. When we tested the second, new hypothesis by direct calculation of the HR we found that the calculated HR was remarkably similar to RSA and that this became more profound under slow and deep breathing. When the HR was prescribed, we found that cardiac work was minimized for RSA‐like HR functions when the blood partial pressure of carbon dioxide was controlled, most profoundly under slow and deep breathing. These findings provide new insights into potential benefits of RSA under physiological conditions. Supported by NIH grant R01 NS069220.
Instantaneous Reduction of Graphene Oxide Paper for Supercapacitor Electrodes with Unimpeded Liquid Permeation (2014)

Scanning positive column of atmospheric-pressure glow discharge (AGD) plasma is proposed as an eco-friendly and cost-effective strategy toward the instantaneous (∼2 s) reduction of graphene oxide (GO) paper, further leading to a reduced graphene oxide (rGO) paper with unimpeded liquid permeation for high performance supercapacitors. Unlike previous finding that AGD plasma has no effect on GO, a well-designed AGD plasma containing scanning positive column region is demonstrated to be capable of converting GO paper to rGO paper. With the synergy of energetic electrons (electron density 1.03 × 1016 cm–3) and surface touch heating (translational temperature ∼800 K), restoration of graphene’s excellent electrical properties is realized, evidenced by a substantially (5 orders of magnitude) improved electrical conductivity. Moreover, the ultrafast reduction of oxygen functionalities results in the creation of exposed open channels and the expansion of graphene layers, leading to a rGO paper supercapacitor electrode with unimpeded liquid permeation. Taking the above advantages, the as-obtained rGO paper exhibits obviously better capacitive and rate performance than the parent GO and chemically reduced rGO counterparts in terms of higher specific capacitance, better charge/discharge rate response, and faster ion diffusion, holding a great promise for energy storage applications.
Community and Academic Physicians Working Together in Integrated Health Care Systems (2021)

Findings from this study should help guide FPPs, academic medical center leaders, chief medical officers, and professional and trade organizations in working toward positive physician synergy in consolidated health care organizations. Work and cultural considerations must be addressed to honor distinct talents of each physician group, facilitating smooth transition from disparate groups to healthy synergy.
Pediatric cardiac angiography using a 4 French Catheter (1977)

Thirty specially designed 4 French pigtail white Teflon catheters 50 cm in length were utilized for angiography using the retrograde arterial approach in 26 infants and children. Angiographic opacification was considered very satisfactory. Apart from one episode of temporary occlusion of the right coronary artery ostium, there were no other significant complications. The catheters were introduced percutaneously in 21 instances and distal pulses were palpable in 18 patients by the second day after catheterization. At postcatheterization testing with increasing volumes and flow rates, the first rupture occurred, delivering 13 ml at 13 ml/second. On testing an additional 15 catheters using fixed volumes of 5, 10, and 15 ml at increasing flow rates, rupture first occurred at 34, 22, and 18 ml/second, respectively. We conclude that this small catheter is relatively safe and satisfactory for the retrograde arterial approach in the study of infants and children.
Non-steroidal anti-inflammatory drugs reduce optimal antibody production in response to vaccination and vaccinia virus infection (45.18) (2011)

Abstract Protective humoral immune responses generated by vaccination, depends on optimal production of antibodies. Non-steroidal anti-inflammatory drugs (NSAIDs) are used to curb undesirable effects of vaccination such as fever. We previously demonstrated that B cells express the “proinflammatory” enzyme cyclooxygenase-2 (Cox-2) in response to activation stimuli such as the TLR9 ligand CpG DNA. Using genetic approaches and small molecule Cox-2 selective inhibitors, we demonstrated that Cox-2 is crucial for optimal antibody production. Expression of plasma cell transcriptional regulatory factors, including Blimp-1 and Xbp-1, were dependent on Cox-2 activity. Significantly fewer antibody secreting plasma cell precursors were generated in the presence of Cox-2 inhibitors, indicating that Cox-2 is essential for human B cell terminal differentiation. Mice chronically treated with Cox-2 inhibitors produced less neutralizing IgG following live virus infection with vaccinia virus. In vitro studies using human B cells show that all commonly used NSAIDs, as well as Tylenol (acetaminophen), at pharmacologic doses, blunt antibody production. Interestingly, a recent clinical trial showed that Tylenol use in infants blunted antibody responses to a variety of vaccines. These new data support the concept that the Cox pathway is necessary for optimal antibody production. The use of NSAIDs, may impair antibody production to vaccination and to certain infections.
The Imperial Conference of 1911 from Within, by John G. Findlay (1912)

Journal Article The Imperial Conference of 1911 from Within, by John G. Findlay Get access The Imperial Conference of 1911 from Within. By John G. Findlay. London, Constable and Company, 1912.—vii, 175 pp. Edward Porritt Edward Porritt Hartford, Connecticut Search for other works by this author on: Oxford Academic Google Scholar Political Science Quarterly, Volume 27, Issue 4, December 1912, Pages 705–706, https://doi.org/10.2307/2141226 Published: 15 December 1912
Strain differences in pulmonary hypertensive response to monocrotaline alkaloid and the beneficial effect of oral magnesium treatment. (1989)

Magnesium therapy has been shown, by us, to attenuate monocrotaline (MCT)-induced pulmonary artery hypertension (PAH), right ventricular hypertrophy and pathological changes in the pulmonary vasculature in 75% of Sprague-Dawley rats. We studied Wistar rats to determine if there was a strain difference in response to MCT and magnesium therapy. Wistar rats were given 60 mg/kg of MCT and studied 3 weeks later, following a protocol similar to that for Sprague-Dawley rats. There was 100% mortality in Wistar rats weighing less than 230 g. The mortality rate in Sprague-Dawley rats of a similar weight range was significantly less (15%). With 40 mg/kg of MCT, Wistar rats developed pulmonary hypertension and right ventricular hypertrophy comparable to those seen in Sprague-Dawley rats administered 60 mg/kg MCT. The percent weight gain over a 3-week period was significantly higher in the Wistar control group than that in the Sprague-Dawley controls (61 vs. 39%; p less than 0.05). Oral magnesium therapy (magnesium aspartate HCl) attenuated pulmonary hypertension and right ventricular hypertrophy in 100% of the Wistar rats studied. A group of Sprague-Dawley rats was given 40 mg/kg of MCT and studied 3 weeks later. PAH and right ventricular hypertrophy in this group were not significantly different from the rats of the same strain injected with the higher dose of MCT. In conclusion, faster growing rats (Wistar) appear to be more sensitive to MCT. Both strains show a significant attenuation of cardiopulmonary changes induced by MCT when treated with oral magnesium.
Recent technology for particle detection on patterned wafers (1995)

Laser scanning techniques for detection of particles on patterned wafers are mainly used as in-line particle monitors in the semiconductor manufacturing line. However, as pattern sizes decrease, the complicated signal from the patterned surface is difficult to separate from the signals caused by small particles on the wafers. To reduce such pattern noise in the detection of smaller particles, the following new techniques have been developed. (1) Automatic spatial filtering in the back-focal plane (the Fourier Transform plane) for blocking repetitive pattern noise. (2) Die-to-die signal comparison to cancel non-repetitive pattern noise. (3) Variable threshold level setting for high-level pattern noise. The physics of each method and their effects on reduction of the pattern noise are described. The total performance of the particle inspection system is also discussed.
45 GHz VCSEL with Multiple Transverse-Coupled-Cavities (2020)

We propose a VCSEL laterally coupled to multiple-cavities providing modulation bandwidth beyond the relaxation-oscillation-frequency. We show a 3dB modulation bandwidth of 45 GHz, five times greater than its conventional VCSEL fabricated on the same epi-wafer.
Application of microwave absorbers in multilayer antenna arrays (2003)

Some practical problems concerning the application of microwave absorbers in multilayer antenna arrays are discussed. Several examples are described for illustration of the suppression of parasitic influences and excitations in the antenna feeds: resonance attenuation and phase delay in meandered microstrip lines; parallel-plate modes in stripline feeds, resonance coupling between different layers etc. The utilization of absorbing microwave coating for realization of simple attenuators/phase shifters, as well as planar loads for distributing components in antenna feeds are additionally considered.
Thrombin increases expression of fibronectin antigen on the platelet surface. (1980)

Fibronectins (fn) are adhesive glycoproteins which bind to collagen and to fibrin and appear to be important in cellular adhesion to other cells or surfaces. Fn-related antigen is present in human platelets, suggesting a possible role for fn in the adhesive properties of platelets. We have studied the localization of fn in resting and thrombin-stimulated platelets by immunofluorescence and quantitative binding of radiolabeled antibody. In resting fixed platelets, variable light surface staining for fn was observed. When these cells were made permeable to antibody with detergent, staining for fn was markedly enhanced and was present in a punctate distribution, suggesting intracellular localization. Stimulation with thrombin, which is associated with increased platelet adhesiveness, resulted in increased staining for fn antigen on intact platelets. These stimulated cells did not leak 51Cr nor did they stain for F-actin, thus documenting that the increased fn staining was not due to loss of plasma membrane integrity. The thrombin-induced increase in accessible platelet fn antigen was confirmed by quantitative antibody binding studies in which thrombin-stimulated platelets specifically bound 15 times as much radiolabeled F(ab')2 anti-fn as did resting cells. Thus, thrombin stimulation results in increased expression of fn antigen on the platelet surface. Here it may participate in interactions with fibrin, connective tissue, or other cells.