gebhart/patrepeval huggingface dataset:
Poly(1,2-phenylenevinylene)s Bearing Nitronyl Nitroxide and Galvinoxyl at the 4-Position:  π-Conjugated and Non-Kekulé-Type Polyradicals with a Triplet Ground State (1997)

Poly[4-(4‘,4‘,5‘,5‘-tetramethyl-3‘-oxido-1‘-oxylimidazolinium-2‘-yl)-1,2-phenylenevinylene] (1) and poly[4-[(3,5-di-tert-butyl-4-oxyphenyl)(3,5-di-tert-butyl-4-oxocyclohexa-2,5-diene-1-ylidene)methyl]-1,2-phenylenevinylene] (2) were synthesized via the polymerization of 2-bromo-4-[1‘,3‘-bis(tert-butyldimethylsiloxy)-4‘,4‘,5‘,5‘-tetramethylimidazolin-2‘-yl]styrene (10) and 2-iodo-4-[(3,5-di-tert-butyl-4-acetoxyphenyl)(3,5-di-tert-butyl-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]styrene (12), respectively, using a palladium catalyst. Their spin (radical) concentration could be increased beyond 0.9 per molar monomer unit, and they were stable even in air at room temperature. The polyradicals satisfied an alternant but non-Kekulé-type π-conjugated structure and displayed a triplet ground state or an intramacromolecular ferromagnetic spin coupling in the SQUID magnetization measurement.
Rational Design of Antibody Protease Inhibitors (2015)

The bovine antibody BLV1H12, which has an ultralong CDR3H, provides a novel scaffold for engineering new functions into the antibody's variable region. By modifying the β-strand "stalk" of BLV1H12 with sequences derived from natural or synthetic protease inhibitors, we have generated antibodies that inhibit bovine trypsin and human neutrophil elastase (HNE) with low nanomolar affinities. We were also able to generate a humanized variant using a human immunoglobulin scaffold that shares a high degree of homology with BLV1H12. Further optimization yielded a highly selective humanized anti-HNE antibody with sub-nanomolar affinity. This work demonstrates a novel strategy for generating antibodies with potent and selective inhibitory activities against extracellular proteases involved in human disease.
Morphology of Holographic Polymer Dispersed Liquid Crystal Reflection Gratings Written in Thiol-ene and Acrylate Polymer Hosts: Part I-Grating Formation (2003)

Journal Article Morphology of Holographic Polymer Dispersed Liquid Crystal Reflection Gratings Written in Thiol-ene and Acrylate Polymer Hosts: Part I-Grating Formation Get access DW Tomlin, DW Tomlin UES, Inc, 4401 Dayton-Xenia Road, Dayton, OH 45432 Search for other works by this author on: Oxford Academic Google Scholar LV Natarajan, LV Natarajan Science Applications International Corporation, 4031 Col. Glenn Highway, Dayton, OH 45431 Search for other works by this author on: Oxford Academic Google Scholar VP Tondiglia, VP Tondiglia Science Applications International Corporation, 4031 Col. Glenn Highway, Dayton, OH 45431 Search for other works by this author on: Oxford Academic Google Scholar RL Sutherland, RL Sutherland Science Applications International Corporation, 4031 Col. Glenn Highway, Dayton, OH 45431 Search for other works by this author on: Oxford Academic Google Scholar TJ Bunning TJ Bunning Air Force Research Laboratory, Materials and Manufacturing Directorate, WPAFB, OH 45433 Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 9, Issue S02, 1 August 2003, Pages 382–383, https://doi.org/10.1017/S1431927603441913 Published: 19 July 2003
Design and fabrication of a metamaterial gradient index diffraction grating at infrared wavelengths (2011)

We demonstrate the design, fabrication and characterization of an artificially structured, gradient index metamaterial with a linear index variation of Δn ~ 3.0. The linear gradient profile is repeated periodically to form the equivalent of a blazed grating, with the gradient occurring across a spatial distance of 61 μm. The grating, which operates at a wavelength of 10.6 μm, is composed of non-resonant, progressively modified "I-beam" metamaterial elements and approximates a linear phase shift gradient using 61 distinguishable phase levels. The grating structure consists of four layers of lithographically patterned metallic I-beam elements separated by dielectric layers of SiO(2). The index gradient is confirmed by comparing the measured magnitudes of the -1, 0 and +1 diffracted orders to those obtained from full wave simulations incorporating all material properties of the metals and dielectrics of the structures. The large index gradient has the potential to enable compact infrared diffractive and gradient index optics, as well as more exotic transformation optical media.
Adaptive Cache Design to Enable Reliable Low-Voltage Operation (2010)

The performance/energy trade-off is widely acknowledged as a primary design consideration for modern processors. A less discussed, though equally important, trade-off is the reliability/energy trade-off. Many design features that increase reliability (e.g., redundancy, error detection, and correction) have the side effect of consuming more energy. Many energy-saving features (e.g., voltage scaling) have the side effect of making systems less reliable. In this paper, we propose an adaptive cache design that enables the operating system to optimize for performance or energy efficiency without sacrificing reliability. Our proposed mechanism enables a cache with a wide operating range, where the cache can use a variable part of its data array to store error-correcting codes. A reliable, energy-efficient cache can use up to half of its data array to store error-correcting codes so that it can reliably operate at a low voltage to reduce energy. A reliable high-performance cache uses its whole data array, but operates at a higher voltage to improve reliability while sacrificing energy. We propose a hardware mechanism that allows the operating system to choose different points within that operating range based on the desired levels of performance, energy, and reliability.
Raman-based distributed temperature sensing supported by integrated-optics technology (2007)

Exploitation of integrated-optic capabilities in terms of compactness and low-cost are demonstrated in distributed temperature sensing experimentation. Design and characterization of an integrated-optic circuit in SiON technology with high index contrast suitable for Raman-based fiber sensor are presented.
Fungal natural products in research and development (2014)

To date approximately 100 000 fungal species are known although far more than one million are expected. The variety of species and the diversity of their habitats, some of them less exploited, allow the conclusion that fungi continue to be a rich source of new metabolites. Besides the conventional fungal isolates, an increasing interest in endophytic and in marine-derived fungi has been noticed. In addition new screening strategies based on innovative chemical, biological, and genetic approaches have led to novel fungal metabolites in recent years. The present review focuses on new fungal natural products published from 2009 to 2013 highlighting the originality of the structures and their biological potential. Furthermore synthetic products based on fungal metabolites as well as new developments in the uses or the biological activity of known compounds or new derivatives are discussed.
Example‐Based Colour Transfer for 3D Point Clouds (2021)

Abstract Example‐based colour transfer between images, which has raised a lot of interest in the past decades, consists of transferring the colour of an image to another one. Many methods based on colour distributions have been proposed, and more recently, the efficiency of neural networks has been demonstrated again for colour transfer problems. In this paper, we propose a new pipeline with methods adapted from the image domain to automatically transfer the colour from a target point cloud to an input point cloud. These colour transfer methods are based on colour distributions and account for the geometry of the point clouds to produce a coherent result. The proposed methods rely on simple statistical analysis, are effective, and succeed in transferring the colour style from one point cloud to another. The qualitative results of the colour transfers are evaluated and compared with existing methods.
Rearrangement of ammonium ylides produced by intramolecular reaction of catalytically generated metal carbenoids. Part 2. Stereoselective synthesis of bicyclic amines (2001)

Ammonium ylides produced by intramolecular reaction of copper carbenoids tethered to cyclic allylic amines undergo [2,3]-rearrangement to deliver bicyclic amines. The reaction can be performed using a cyclic N-allylamine in which the diazo group is tethered adjacent to nitrogen, or a vinyl-substituted cyclic amine in which the diazo group is N-tethered to the ring. In the former type of reaction, stereoselective ylide formation and rearrangement usually delivers high levels of diastereocontrol. In the latter case, efficient ‘chirality transfer’ can be accomplished when the reaction is performed using an enantiomerically pure substrate. The reactions have been used to construct pyrrolizidine, indolizidine and quinolizidine systems, and the CE sub-unit found in the manzamine and ircinal alkaloids.
Application of Oxathiaphospholane Method for the Synthesis of Oligodeoxyribonucleotide 5′-O-Conjugates (1998)

Abstract 2-Thiono-1,3,2-oxathiaphospholane derivatives of lipophilic alcohols including borneol, cholesterol, menthol and heptadecanol were synthesized and reacted with support-bound oligodeoxyribonucleotides containing free 5′-hydroxyl groups. The reaction is catalyzed by DBU and leads to oligodeoxyribonucleotide conjugates possessing a lipophilic alcohol residue bound at the 5′-end via a phosphorothioate linkage.
Vigorous-intensity exercise as a modulator of cardiac adipose tissue in women with obesity: a cross-sectional and randomized pilot study (2023)

Cardiac adipose tissue (CAT) has become an important target for the reduction of disease risk. Supervised exercise programs have shown potential to "significantly" reduce CAT; however, the impact of different exercise modalities is not clear, and the relationships between CAT, physical activity (PA) levels and fitness (PFit) remain unknown. Therefore, the purpose of this study was to analyze the relationships between CAT, PA and PFit, and to explore the effects of different exercise modalities in a group of women with obesity. A total of 26 women (age: 23.41 ± 5.78 years-old) were enrolled in the cross-sectional study. PA, cardiorespiratory fitness, muscular strength, body composition and CAT were evaluated. The pilot intervention included 16 women randomized to a control (CON, n=5), high intensity interval training (HIIT, n = 5) and high-intensity circuit training (HICT, n=6) groups. Statistical analysis showed negative correlations between CAT and vigorous PA (VPA) (<i>r</i> <sub>s</sub>=-0.41, <i>p</i>=0.037); and between percent body fat (%BF), fat mass (FM), and all PA levels (<i>r</i> <sub>s</sub>=-0.41- -0.68, <i>p</i><0.05); while muscle mass was positively associated with moderate-to-vigorous PA, and upper-body lean mass with all PA levels (<i>r</i> <sub>s</sub> =0.40-0.53, <i>p</i><0.05). The HICT intervention showed significant improvements (<i>p</i><0.05) in %BF, FM, fat free mass, and whole-body and lower extremities lean mass and strength after three weeks; however, only leg strength and upper extremities' FM improved significantly compared to CON and HICT. In conclusion, although all types of PA showed a positive influence on body fat content, only VPA significantly impacted on CAT volume. Moreover, three weeks of HICT induced positive changes in PFit in women with obesity. Further research is needed to explore VPA levels and high-intensity exercise interventions for short- and long-term CAT management.
Carrier depletion based silicon optical modulators (2010)

Silicon optical modulators have generated an increasing interest in the recent years, as their performances are crucial to achieve high speed optical links. Among possibilities to achieve optical modulation in silicon-based materials, index variation by free carrier concentration variation has demonstrated good potentiality. High speed and low loss silicon modulators can be obtained by carrier depletion inside lateral PN or PIPIN diodes. When the diode is reverse biased, refractive index variations are obtained and then phase modulation of the guided wave is obtained. Mach-Zehnder interferometers are used to convert phase modulation into intensity modulation. Experimental results are presented for both PN and PIPIN diodes.
Design and implementation of Pep, a JavaTM just-in-time translator (1997)

Java, a new object-oriented member of the C family of languages, has become popular in part because it emphasizes portability. Portability is achieved by compiling programs to machine-independent bytecodes that can be interpreted on a Java virtual machine. Unfortunately, interpreted performance does not match native code performance. A just-in-time compiler can regain performance without sacrificing portability by turning the bytecodes into native code at runtime. This idea has a proven track record: Deutsch and Schiffman presented a dynamic Smalltalk compiler in 1984 [5], and the Self system currently sports a dynamic type-feedback based optimizing compiler [12]. To study the performance potential of Java with this state-of-the-art optimization technology, we built Pep, a just-in-time compiler from Java bytecodes to Self. Following translation by Pep, Java programs can execute on the Self virtual machine and benefit from the optimizations performed by Self's compiler. We describe the design and implementation of Pep, focusing on concepts and trade-offs, but also compare performance with the JDK 1.0.2 and 1.1 interpreters. © 1997 John Wiley & Sons, Inc.
The Influence of Radiation Trapping on the Measurements of Cross Sections for Excited-Atom?Excited-Atom Collisions (2000)

Radiation trapping has an important influence on the measurement of the cross sections of collisions between excited atoms, like energy-pooling collisions, Penning ionization, and associative ionization. In this paper, we first set up the exact relations for computing the cross sections from measurements influenced by trapping and discuss their practical applicability. Since the observation geometry is usually not known exactly, we discuss ways to calibrate it out. In contrast to the untrapped case, no complete elimination of geometry effects is possible. The sensitivity of various experimental geometries to modelling errors is discussed.
Three‐dimensional membranes for artificial lungs: Comparison of flow‐induced hemolysis (2021)

TPMS-shaped membranes offer a safe way to improve gas transfer in artificial lungs.
On optimum tooth profile modification to minimize dynamic mesh forces in planetary gears (2015)

International audience
Tregs in T cell vaccination: exploring the regulation of regulation (2004)

T cell vaccination (TCV) activates Tregs of 2 kinds: anti-idiotypic (anti-id) and anti-ergotypic (anti-erg). These regulators furnish a useful view of the physiology of T cell regulation of the immune response. Anti-id Tregs recognize specific effector clones by their unique TCR CDR3 peptides; anti-id networks of CD4+ and CD8+ Tregs have been described in detail. Here we shall focus on anti-erg T regulators. Anti-erg T cells, unlike anti-id T cells, do not recognize the clonal identity of effector T cells; rather, anti-erg T cells recognize the state of activation of target effector T cells, irrespective of their TCR specificity. We consider several features of anti-erg T cells: their ontogeny, subset markers, and target ergotope molecules; mechanisms by which they regulate other T cells; mechanisms by which they get regulated; and therapeutic prospects for anti-erg upregulation and downregulation.
Vacuum-Ultraviolet Transparency of Silica Glass and its Interaction with Vacuum-Ultraviolet Lasers. (2002)

Silica glass is a promising optical material in the deep-ultraviolet (DUV, -4.1-6.2 eV or 300-200 nm) to vacuum-ultraviolet (VUV, >-6.2 eV or <-200 nm) region since its optical band gap is located at-8 eV. For such a purpose, it is crucial to control its band-edge transparency and optical resistivity against the intense laser radiation of DUV-VUV excimer lasers (KrF ; 5.0 eV or 248 nm, ArF ; 6.4 eV or 193 nm, F2 ; 7.9 eV or 157 nm) . The present article reviews our recent studies on silica glasses irradiated with DUV-VUV excimer lasers, including several topics of the improvement of optical transparency by introducing Si-F terminals, the photostructural change of SiOH groups, the formation and annealing kinetics of laser-induced point-defects involving the role of hydrogen, and the application of F-doped glasses to DUV optical fibers.
Die kombinierte und sequentielle Leber-Nieren-Transplantation (2010)

Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Chemo-and Stereoselectivity of Nucleophilic Substitution in Mixed Phosphorus-Carboxylic Anhydrides (1999)

Abstract Miwed phosphorus-carboxylic anhydrides have demonstrated both acylating and phosphorylating properties.[1] Here we report the reactivity of O,O-diethyl(O-2,4,6-trimethylbenzoyl) phosphates (1), and O-methyl (O-2,4,6-trimetyIbenzoyl) dimethylphosphonates (2)with nucleophiles in the presence of different strong organic bases (DBU, DMAP).
Frequency domain IQ imbalance estimation in the presence of DC offset and frequency offset (2009)

Direct conversion receivers in orthogonal frequency division multiplexing (OFDM) systems suffer from direct current (DC) offset, frequency offset, and IQ imbalance. We have proposed an IQ imbalance estimation scheme in the presence of DC offset and frequency offset, which uses preamble signals in the time domain. In this scheme, the DC offset is eliminated by a differential filter. However, the accuracy of IQ imbalance estimation is deteriorated when the frequency offset is small. To overcome this problem, a new IQ imbalance estimation scheme in the frequency domain has been proposed in this paper. The IQ imbalance is estimated with pilot subcarriers. Numerical results obtained through computer simulation show that estimation accuracy and bit error rate (BER) performance can be improved even if the frequency offset is small.
Secure access wrapper: mediating security between heterogeneous databases (2002)

Organizations today are faced with an ever-increasing need to become more efficient in their methods for exchange of information with consumers, collaborators, and partners. Unfortunately existing mechanisms for such information exchange provide nowhere near the levels of both security and automation required to satisfy this need. Effective information sharing and dissemination can take place only if the data holders have assurance that access constraints on the information they own or manage will be respected and that, while releasing information, disclosure of sensitive information is not a risk. The Secure Access Wrapper (SAW) project is a collaborative effort between SRI International and Stanford University to develop techniques that provide substantially more automation and assurance than has previously been available for secure, selective information sharing. The SAW project is sponsored by DARPA ITO under the Wrappers and Composition focus area of the Information Survivability program.
The Role of Gold Catalysts in C–H Bond Activation for the Selective Oxidation of Saturated Hydrocarbons (2015)

Activation of C-H bonds during the combustion of saturatedhydrocarbons is an extremely important step for the generation ofpower and heat. The hardest step is the activation of the ﬁrst C-Hbond. Once the ﬁrst bond breaks, the consecutive reactions proceedmore easily. Therefore, understanding the C-H bond activation insaturated hydrocarbons is important. It also improves the approachto assessing the eﬀect of catalytic and reaction parameters on therate and the eﬃciency of catalytic combustion. Many diﬀerent typesof catalysts are capable of oxidizing saturated hydrocarbons withvarying eﬃciency. Among the saturated hydrocarbons methane isthe most diﬃcult compound to activate, higher hydrocarbons areeasier to activate, and the hydrocarbons from C2 to C4 exhibitan intermediate diﬃculty for bond activation. The diﬀerence inactivity of hydrocarbons can partly be related with the adsorptionof hydrocarbons on oxide surfaces, which is considered as a priorcondition to combustion. Adsorption of a larger molecule in apredissociative state is more eﬃcient than for a smaller molecule.C-H bond activation requires harsher conditions, particularly highertemperature. The optimal temperature for selective oxidation of analkane C-H bond until 2002 was shown by Thomas et al. [1-3]to be 100◦C using transition metal ion-substituted molecular sieve catalysts, followed by use of gold catalysts by Xu et al. [4] in 2005 at70◦C.
Preparation of Rhodium Nanoparticles in Carbon Dioxide Induced Ionic Liquids and their Application to Selective Hydrogenation (2008)

In der Falle: Katalytisch aktive Nanopartikel lassen sich mithilfe von überkritischem CO2 in festen ionischen Matrices herstellen und stabilisieren. Als Matrix finden dabei einfache Ammoniumsalze Verwendung, die durch CO2-induziertes Schmelzen ionische Flüssigkeiten bilden. Die so hergestellten festen und leicht handhabbaren Materialien katalysieren selektiv die Hydrierung sterisch stark gehinderter aromatischer Olefine.
Supplementary Table S7 from Genomic Features of Exceptional Response in Vemurafenib ± Cobimetinib–treated Patients with <i>BRAF</i><sup>V600</sup>-mutated Metastatic Melanoma (2023)

Supplementary Table S7 from Genomic Features of Exceptional Response in Vemurafenib ± Cobimetinib–treated Patients with &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;V600&lt;/sup&gt;-mutated Metastatic Melanoma
Kriging-guided level set method for crash topology optimization (2017)

Crashworthiness optimization problems are characterized by strong nonlinearities and discontinuities.&#13;\nHence, gradient-based methods cannot be used and alternative approaches have&#13;\nto be considered. Here, a novel, kriging-based method for level set topology optimization is&#13;\nproposed and validated on a crash test case. Compared to CMA-ES, this method demonstrates&#13;\nto be efficient in terms of convergence speed and promising in the context of crash topology optimization.
Iron-exchanged high-silica LTA zeolites as hydrothermally stable NH3-SCR catalysts (2019)

Iron-exchanged high-silica LTA zeolites exhibit high activity for selective catalytic reduction of NO<sub>x</sub> by NH<sub>3</sub>, even after hydrothermal aging at 900 °C.
Designing a Stable Cathode with Multiple Layers to Improve the Operational Lifetime of Polymer Light‐Emitting Diodes (2009)

Abstract The short device lifetime of blue polymer light‐emitting diodes (PLEDs) is still a bottleneck for commercialization of self‐emissive full‐color displays. Since the cathode in the device has a dominant influence on the device lifetime, a systematic design of the cathode structure is necessary. The operational lifetime of blue PLEDs can be greatly improved by introducing a three‐layer (BaF 2 /Ca/Al) cathode compared with conventional two‐layer cathodes (BaF 2 /Al and Ba/Al). Therefore, the roles of the BaF 2 and Ca layers in terms of electron injection, luminous efficiency, and device lifetime are here investigated. For efficient electron injection, the BaF 2 layer should be deposited to the thickness of at least one monolayer (∼3 nm). However, it is found that the device lifetime does not show a strong relation with the electron injection or luminous efficiency. In order to prolong the device lifetime, sufficient reaction between BaF 2 and the overlying Ca layer should take place during the deposition where the thickness of each layer is around that of a monolayer.