gebhart/patrepeval huggingface dataset:
Abstract A112: RanBP9 protects cells from genotoxic stress and increased expression is predictive of worse response to platinum in NSCLC patients (2018)

Abstract Platinum-based therapies currently represent the most common first-line treatment for non-small cell lung cancer (NSCLC). The efficacy of platinum compounds depends on the activation of the cellular DNA damage response (DDR), which leads to cancer cell death. However, severe toxic effects and development of resistance represent major limitations in the use of these drugs. Thus, a better mechanistic understanding and new prognostic and predictive biomarkers of the DDR are required to improve outcomes of NSCLC treatment. We have previously reported that RanBP9 (Palmieri et al., 2016), a poorly characterized scaffold protein, participates in the DDR and that its downregulation causes enhanced sensitivity to DNA damage induced by ionizing radiation. In the present study, we used immunohistochemical analysis to reveal that RanBP9 expression is significantly and commonly elevated in 178 lung tumors of different histotypes compared to their normal adjacent tissue (p&amp;lt;0.02 - 0.001). We also show that knockout (KO) of RanBP9 in A549 NSCLC cell lines resulted in reduced DDR and higher levels of cisplatin-induced apoptosis both in vitro and in vivo. These findings were validated by a retrospective analysis of 134 NSCLC patients in which higher levels of RanBP9 associated with tumor stage (p&amp;lt;0.0001), and poor response to platinum compounds as first-line treatment (PFS, HR (RanBP9 positive vs negative) 1.71, 95% CI 1.142 - 2.563, p = 0.0093). Finally, we show that ablation of RanBP9 is associated with overactivation of poly(ADP-ribose) polymerase (PARP) and increased cisplatin antineoplastic efficacy in combination with PARP inhibitors, indicating that the absence of RanBP9 results in a BRCAness-like phenotype. Overall, these results reveal that RanBP9 is a novel predictive biomarker of response to genotoxic treatments in NSCLC, paving the way to prospective studies aimed at assessing its clinical prognostic value and therapeutic targeting. Citation Format: Anna Tessari, Kareesma Parbhoo, Meghan Pawlikowski, Matteo Fassan, Eliana Rulli, Claudia Foray, Alessandra Fabbri, Valerio Embrione, Monica Ganzinelli, Marina Capece, Moray J. Campbell, Massimo Broggini, Krista La Perle, Gabriella Farina, Sara Cole, Mirko Marabese, Joseph M. Amann, David P. Carbone, Marina C. Garassino, Carlo M. Croce, Dario Palmieri, Vincenzo Coppola. RanBP9 protects cells from genotoxic stress and increased expression is predictive of worse response to platinum in NSCLC patients [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2017 Oct 26-30; Philadelphia, PA. Philadelphia (PA): AACR; Mol Cancer Ther 2018;17(1 Suppl):Abstract nr A112.
Antimicrobial properties of the peptide substance Bacillus Subtilis PSF-19 (2019)

The subject of the study is a strain of Bacillus subtilis PSF-19 isolated by us from vegetable raw materials (Passiflora preparation), which is capable of producing antimicrobial substance (AMV) suppressing pathogenic bacteria. The article discusses the method and conditions of extraction from the culture fluid fraction of AMV, active against Listeria monocytogenes – one of the dangerous intestinal pathogens that infect food. Using biochemical methods and mass spectroscopy, the molecular weight and the peptide nature of the active fraction of AMV were determined. A fraction of AMV with a molecular weight of 3,4–3,6 kDa has bactericidal activity, which is destroyed by treatment with proteolytic enzymes, which allowed it to be attributed to the group of low-molecular antimicrobial peptides – bacteriocins. The studies allow to consider the strain Bacillus subtilis PSF-19 as a producer of bacteriocin, especially effective against pathogens of intestinal listeriosis. The establishment of the fact of destructibility of proteolytic enzymes, finding the conditions of microbiological synthesis of AMV, its isolation and accumulation for research, provide opportunities for practical use as a means for decontamination of the environment instead of traditional antibiotics.
Optical design dependence on technology development (2009)

Specific developments in optical technology over the past thirty years including refractive materials, thin film coatings and surface profiles will be discussed. A large variety of optical designs which depend on some of these developments will be described. The optical design examples presented will cover the infrared, visible, ultraviolet and combinations of these wavebands. A novel multi-waveband optical system that utilizes many of these developments will be illustrated in several possible configurations to meet different application requirements. A summary of the technologies employed in all of the optical design examples will indicate whether or not there may be trends in optical technology development. The optical design examples will be taken from issued Patents or published Patent applications and hence their optical prescriptions will be available for detailed analysis.
Combined pulmonary fibrosis and emphysema syndrome associated withABCA3mutations (2013)

The next step for our study will be direct determination, such as faecal H. pylori antigens or H. pylori determination in BAL (i.e.DNA PCR or culture), in a wide population of IPF patients.The effects of IPF pharmacological treatments on H. pylori infection remain to be established.
Polyvinylidene fluoride films as infrared to visible converter material (1996)

Polyvinylidene fluoride (PVDF) films suitable for infrared to visible image conversion at the wavelength of 10.6 μm are investigated. Birefringent PVDF films are simultaneously exposed to infrared and visible radiations and the variation of the transmitted intensity at 633 nm is measured as a function of the incident infrared intensity. The possibility of using PVDF films as infrared to visible image converter material is demonstrated.
Nanofiltration (2013)

Abstract Nanofiltration (NF) is, formally, the pressure‐driven membrane process that fills the gap between reverse osmosis (RO) and ultrafiltration (UF). Because the name of the process was introduced and accepted rather late (in the 1980s), the process boundaries are not well defined, so that NF has features of both neighboring processes, combined with the process' own specificities. This transitional profile makes NF to an exceptionally interesting technology, particularly because it operates in the range of applications for removal of small organic solutes in the range of 200–2000 g/mol, and (partial) removal of inorganic ions, with the additional potential of separating mono‐ and multivalent ions. The combination of the dual nature of NF as a process intermediate to RO and UF and its specific challenges and opportunities are shown in this article. Membrane materials and synthesis methods are described in brief and to the extent that they differ from general methods of membrane manufacturing. Properties of membranes and membrane materials prove to be necessary for understanding the performance of filtration and separation, which will be shown through a combined approach based on experimental insights and modeling. Solvent‐resistant nanofiltration (SRNF) is described separately as one of the newly emerging membrane processes, with a very large potential for separations in the chemical, petrochemical, pharmaceutical, as well as food and related industries. The performance of SRNF will be related to physicochemical parameters, which eventually should allow prediction of the process performance. For aqueous applications, special attention is paid to membrane fouling in NF, which remains one of the main points of attention. The approach followed here is that of the resistance‐in‐series model, in which flux decline is split up into its different contributing effects, aiming at identifying and controlling the most significant contributors. It is suggested that adsorption of organic solutes and pore blocking are potentially the most important mechanisms of flux decline that are difficult to control. The most important applications of NF (in aqueous solutions) are outlined: production of drinking water (with focus on newly emerging applications such as the removal of a wide range of micropollutants), applications in wastewater treatment and water recycling, and the use of NF in fractionation processes. Finally, a brief indication is given of the challenges for NF and NF membranes that remain to be solved.
Attack-tolerant distributed sensing for dynamic spectrum access networks (2009)

Accurate sensing of the spectrum condition is of crucial importance to the mitigation of the spectrum scarcity problem in dynamic spectrum access (DSA) networks. Specifically, distributed sensing has been recognized as a viable means to enhance the incumbent signal detection by exploiting the diversity of sensors. However, it is challenging to make such distributed sensing secure due mainly to the unique features of DSA networks - openness of a low-layer protocol stack in SDR devices and non-existence of communications between primary and secondary devices. To address this challenge, we propose attack-tolerant distributed sensing protocol (ADSP), under which sensors in close proximity are grouped into a cluster, and sensors in a cluster cooperatively safeguard distributed sensing. The heart of ADSP is a novel shadow fading correlation-based filter tailored to anomaly detection, by which the fusion center prefilters abnormal sensor reports via cross-validation. By realizing this correlation filter, ADSP minimizes the impact of an attack on the performance of distributed sensing, while incurring minimal processing and communications overheads. The efficacy of our scheme is validated on a realistic two-dimensional shadow-fading field, which accurately approximates real-world shadowing environments. Our extensive simulation-based evaluation shows that ADSP significantly reduces the impact of attacks on incumbent detection performance.
Microarray Analysis of the Peripheral Monocytes From Waldenstrom's Macroglobulinemia Patients Reveals a Distinct Gene Expression Profile (2010)

Abstract Abstract 2010 Background: Waldenstrom's macroglobulinemia (WM) is a B-cell malignancy characterized by the accumulation, predominantly in the bone marrow, of clonally related IgM-secreting lymphoplasmacytic cells. Macrophage derived inflammatory factors are elevated in WM suggesting a possible contribution by monocytes to the growth and survival of WM cells. Patients and Method: Monocytes (CD14+) from the peripheral blood of 8 untreated WM patients, and 6 healthy donors (HDs) were isolated by immunomagnetic bead sorting. Gene expression profiling was then performed using Human Genome U133 Plus 2.0 chips, and data obtained from microarray was analyzed by dChip software with fold change &gt;=2 and p&lt;=0.05 as cut off points. Validation was performed by real time PCR. Results: Using Panther classification, 284 transcripts were identified as significantly different in monocytes derived from WM patients versus HDs. The resulted transcripts are involved in many critical signaling pathways, such as Toll-like immune receptor pathway (i.e. TLR1, TLR4, TLR8, TICAM); inflammatory response (i.e. CD40, PTAFR, FPR2), integrin binding (i.e. RAC2, ILK), chemokinesis (i.e. CCR2, CX3CR1), apoptosis (i.e. TNFSF10), p53 signaling (i.e. GADD45A, 1433F) and G-protein coupled receptors (i.e. CX3CR1). Fifteen of 21 genes were validated by real-time PCR, and were over-expressed in peripheral blood monocytes from WM patients in comparison to healthy age matched donors: Conclusion: Peripheral monocytes from WM patients demonstrate a distinct gene expression profile characterized by up-regulation of genes affecting Toll-like innate immunity, inflammation, and apoptosis. These studies define a distinct microenvironmental signature, and provide a framework for the exploration of novel targets for prognosis and therapy in WM. Disclosures: No relevant conflicts of interest to declare.
Pd-Catalyzed Ring Restructuring of Oxazolidines with Alkenes Leading to Fused Polycyclic Indolizines (2022)

A palladium-catalyzed reaction of <i>N</i>-propargyl oxazolidines with alkenes for the synthesis of indolizidines has been developed. Through a sequential 6-<i>exo</i>-dig cyclization/proton transfer/[3+2] cycloaddition/cycloreversion/aromatization process, a series of fused polycyclic indolizines are obtained in moderate to good yields with high functional group tolerance. Experimental and theoretical studies suggest that the [3+2] cycloaddition/cycloreversion of the oxazolidine ring probably involves C-C and C-O bond cleavage, providing a new ring restructuring approach for the synthesis of heterocycles.
Безопасное тестирование симуляции систем с отказами и разрушением (2010)

The paper deals with conformance testing based on formal specications. The con-
cept of safe testing was earlier proposed by the authors for trace based conformance.
This concept is propagated on the case of (weak) simulation based on a relation between
specication and implementation states. The theory of safe simulation of systems with
refusals and destructions is proposed. The problems of complete testing and sucient
conditions for the existense of complete test suite are discussed. The practical algo-
rithm of complete testing for restricted classes of specications and implementations is
described.
Incorporation of exogenous precursors into uridine and ribonucleic acid. Nucleotide compartmentation in the renal cortex in vivo (1979)

The possibility of compartmentation of UTP in vivo was investigated in the renal cortex of unanaesthetized rats. In addition, liver and spleen were studied in order to compare tissues with different utilization of precursors for pyrimidine nucleotide synthesis. After continuous 2h infusions of [(3)H]uridine or [(3)H]orotate, their incorporation into UTP, UDP-sugars and RNA was quantified. Rates of RNA synthesis were calculated by dividing the incorporation of precursor into RNA by the average specific radioactivity of the UTP pool. Although similar RNA-synthesis rates might have been expected with the two precursors, higher rates were found with uridine than with orotate. The relative incorporation into UDP-sugars of these precursors was also different. Similar results were obtained in the liver. In the spleen, equal amounts of both precursors were incorporated into UTP, but [(3)H]orotate incorporation did not lead to labelling of RNA. To evaluate the heterogeneity of cells with respect to the metabolism of pyrimidines, precursor incorporation was studied in isolated glomeruli and by radioautography. Incorporation into glomeruli was qualitatively similar to but quantitatively different from results in the renal cortex. Although there is obvious tissue heterogeneity, compartmentation of UTP pools is the most credible explanation for the results obtained with the renal cortex and liver. Consequently RNA and UDP-sugars may originate from two different UTP pools. Tissue heterogeneity is the likely explanation for the results obtained in the spleen. Studies of synthesis of pyrimidine and RNA, particularly in relation to growth and regeneration, must take into consideration the precursor used, the apparent existence of UTP compartmentation and the degree of cellular heterogeneity.
Integration of 3D Scan Data into the Finite Element Analysis Workflow for Simulation of Rotorcraft Components (2015)

A process for integrating 3D scan data into the finite element analysis (FEA) workflow is presented. The process was developed to utilize CAD and/or scan-based geometry to create a 3D Finite Element model for structural analysis. Three significant phases of the process include surface acquisition, geometric refinement, and FEA evaluation. The scan-based process provides a cost effective method to capture the surface geometry of physical components and permits a digital representation of the article to be created for analysis purposes. It is shown that the role of alignment, deviation checking, and prior analysis are significant factors in efficiently developing models for FEA. The application of scan-based FEA was highly effective in simulating component repairs, weldments, and predicting mechanical test behavior. Results from these applications were substantiated by digital image correlation and strain gauge data, showing excellent correlation between 3-10%. When comparing scan-based FEA results it was found that accounting for paint thickness can have a significant effect on the accuracy of the results. With a successful scan-based FEA approach developed, numerous applications of the process resulted in reduced scrap rate, supported safety of flight testing, and ensured continued on-time delivery of aircraft.
Autologous mesenchymal stem cells produce reverse remodelling in chronic ischaemic cardiomyopathy (2009)

Together these data demonstrate that autologous MSCs can be safely delivered in an adult heart failure model, producing substantial structural and functional reverse remodelling. These findings demonstrate the safety and efficacy of autologous MSC therapy and support clinical trials of MSC therapy in patients with chronic ischaemic cardiomyopathy.
Enhancing light extraction from III-nitride devices using moth-eye nanostructures formed by colloidal lithography (2016)

Summary form only given. We report a novel, reliable, and scalable technique for the surface nanostructuring of GaN by colloidal lithography. Moth-eye protuberances of varying dimensions have been formed on bulk GaN substrates and on samples containing an InGaN multiple-quantum-well active layer, grown by metal organic chemical vapor deposition. Angle-resolved optical characterization and photoluminescence (PL) indicates enhanced transmission through these samples compared to flat, unstructured surfaces. We analyze the potential mechanisms causing this enhancement, such as recycling of PL pump light, improved first-pass extraction, and improved diffuse scattering. The impact of these effects is evaluated using finite-difference time-domain and effective medium theory simulations. Light extraction with moth-eye nanostructures is compared to state-of-the-art methods for c-plane and semipolar GaN surface roughening.
P3: Toward Privacy-Preserving Photo Sharing (2013)

With increasing use of mobile devices, photo sharing services are experiencing greater popularity. Aside from providing storage, photo sharing services enable bandwidth-efficient downloads to mobile devices by performing server-side image transformations (resizing, cropping). On the flip side, photo sharing services have raised privacy concerns such as leakage of photos to unauthorized viewers and the use of algorithmic recognition technologies by providers. To address these concerns, we propose a privacy-preserving photo encoding algorithm that extracts and encrypts a small, but significant, component of the photo, while preserving the remainder in a public, standards-compatible, part. These two components can be separately stored. This technique significantly reduces the signal-to-noise ratio and the accuracy of automated detection and recognition on the public part, while preserving the ability of the provider to perform server-side transformations to conserve download bandwidth usage. Our prototype privacy-preserving photo sharing system, P3, works with Facebook, and can be extended to other services as well. P3 requires no changes to existing services or mobile application software, and adds minimal photo storage overhead.
Acromegaly due to ectopic growth hormone-releasing hormone secretion by a bronchial carcinoid tumour. Dynamic hormonal responses to various stimuli (1991)

Ectopic GHRH is a relatively uncommon cause of acromegaly, which should be differentiated from pituitary adenoma, in order to avoid damage to the pituitary gland from unnecessary interventions. We report here on a 66-year-old man with acromegaly due to a GHRH-secreting bronchial carcinoid tumour, who recovered completely following removal of the tumour. His hormonal status was studied before and after the operation. Basal GH, GHRH, IGF-I and PRL levels, as well as plasma GH response to glucose load and TRH administration were abnormal before the operation, and became normal thereafter. The somatostatin analogue SMS 201-995 was found to be a potent inhibitor of the ectopic GHRH and the GH secretion (greater than 500 to 42 ng/l and 15.4 micrograms/l to 0.8 microgram/l, respectively). The effect on GHRH proved to be due to direct effect of somatostatin on the tumour cells, as demonstrated in tissue culture studies. A mixed meal was found immediately to suppress GHRH levels without such an effect on GH secretion. We conclude that the neuroendocrine tests usually practised in acromegaly cannot differentiate between ectopic GHRH secretion and pituitary adenoma. High plasma GHRH levels may serve as a diagnostic test for excessive GHRH production, which is almost always ectopic. These high levels are suppressible by somatostatin and a mixed meal.
Valorization of two waste streams into activated carbon and studying its adsorption kinetics, equilibrium isotherms and thermodynamics for methylene blue removal (2013)

Wastes must be managed properly to avoid negative impacts that may result. Open burning of waste causes air pollution which is particularly hazardous. Flies, mosquitoes and rats are major problems in poorly managed surroundings. Uncollected wastes often cause unsanitary conditions and hinder the efforts to keep streets and open spaces in a clean and attractive condition. During final disposal methane is generated, it is much more effective than carbon dioxide as a greenhouse gas, leading to climate change. Therefore, this study describes the possible valorization of two waste streams into activated carbon (AC) with added value due to copyrolysis. High efficiency activated carbon was prepared by the copyrolysis of palm stem waste and lubricating oil waste. The effects of the lubricating oil waste to palm stem ratio and the carbonization temperature on the yield and adsorption capacity of the activated carbon were investigated. The results indicated that the carbon yield depended strongly on both the carbonization temperature and the lubricating oil to palm stem ratio. The efficiency of the adsorption of methylene blue (MB) onto the prepared carbons increased when the lubricating oil to palm stem ratio increased due to synergistic effect. The effects of pH, contact time, and the initial adsorbate concentration on the adsorption of methylene blue were investigated. The maximum adsorption capacity (128.89 mg/g) of MB occurred at pH 8.0. The MB adsorption kinetics were analyzed using pseudo-first order, pseudo-second order and intraparticle diffusion kinetic models. The results indicated that the adsorption of MB onto activated carbon is best described using a second order kinetic model. Adsorption data are well fitted with Langmuir and Freundlich isotherms. The thermodynamic parameters; ΔG°, ΔH° and ΔS° indicate that the adsorption is spontaneous and endothermic.