gebhart/patrepeval huggingface dataset:
Association between Neuroticism and Emotional Face Processing (2017)

Neuroticism is one of the "Big Five" personality factors and is characterized by a tendency to experience negative affect. We aimed to investigate how neuroticism influences the neural correlates for processing of emotional facial expressions. 68 healthy participants were presented with emotional dynamic facial stimuli, i.e. happy, neutral or angry, during functional MRI. Brain activations for the contrasts emotional vs. neutral, happy vs. neutral and angry vs. neutral were correlated with individuals' neuroticism scores as obtained by the NEO Five Factor Inventory questionnaire and additionally investigated for gender differences. The bilateral medial temporal gyrus (MTG) was identified as key region in the processing of emotional faces and activations within this region correlated with individual neuroticism scores. Although female participants showed significantly stronger activation differences between emotional and neutral facial expressions in the left MTG, the correlation between activation and neuroticism scores did not show any significant gender differences. Our results offer for the first time a biological correlate within the face processing network for enhanced reactivity of neurotic individuals to emotional facial expressions which occurs similarly for both male and female participants.
Combining Live Cell Imaging with Cellular Impedance to Monitor Apoptotic Cell Death in Real Time (2020)

Although apoptosis can be tracked using various biomarker‐based assays, these typically require multiple manual handling steps and only yield endpoint measurements. Requiring just a cell seeding step and a drug addition step, we used the Agilent xCELLigence RTCA eSight to continuously monitor drug‐mediated apoptosis over the course of multiple days. Providing a direct and objective assessment of cell number, cell size, cell‐substrate attachment strength, and cell barrier function, impedance biosensors embedded within the base of eSight microplates quantitatively track early (cell shrinkage) to late (fragmentation) apoptotic events with high analytical sensitivity. Concurrently, eSight captures live cell images in brightfield and three fluorescence channels (red, green, and blue), providing an orthogonal readout of the apoptosis process. By combining the strengths of real‐time impedance monitoring (simplicity, analytical sensitivity, and objectivity) with that of live cell imaging (specificity of the readout), eSight increases the information richness of the apoptosis assay without increasing the workload. Importantly, the drug EC50 values determined using these two approaches are nearly identical, suggesting that eSight can simultaneously provide both the primary and secondary (confirmatory) readouts for apoptosis studies. Corroborating the impedance response with live cell images. Image panels demonstrate the progression of apoptosis 20 and 40 hours after treating A549‐Blue cells with 5.5 μm MG132. White arrows denote large membrane blebs that contain phosphatidylserine in their outer leaflet. Figure 1 Multiplex monitoring of apoptosis in real‐time: combining readouts from cellular impedance and live cell imaging. Figure 2
Compliant Constant-Force Micro-Mechanism for Enabling Dual-Stage Motion (2012)

This paper describes a fully compliant constant-force micro-mechanism that enables dual-stage motion for nanoinjection. Nanoinjection is a recently developed process for delivering DNA into mouse zygotes via electrostatic accumulation and release of the DNA onto a microelectromechanical system (MEMS) lance. The fully compliant constant-force nanoinjector is a concatenation of two separate mechanisms: a six-bar mechanism with compliant lamina-emergent torsional (LET) joints to raise the lance, and a pair of constant-force crank-sliders with LET joints positioned on either side of the six-bar mechanism to drive the lance forward. The fully compliant nanoinjector exhibits self-reconfiguring metamorphic motion to first raise the lance to the midline of the zygote and then translate the lance forward with a controlled motion. This dual-stage motion is necessary for the lance to pierce the zygote without causing damage to the cell membrane. The device achieves two sequential displacement behaviors in a compliant mechanism fabricated from a single, continuous piece of material.
ChemInform Abstract: Hydridotetrakis(triphenylphosphine)rhodium(I) as an Effective Catalyst for the Regiospecific Hydrosilation of α,β‐Unsaturated Carbonyl Compounds. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Improving Embedding Extraction for Speaker Verification with Ladder Network (2020)

Speaker verification is an established yet challenging task in speech processing and a very vibrant research area. Recent speaker verification (SV) systems rely on deep neural networks to extract high-level embeddings which are able to characterize the users' voices. Most of the studies have investigated on improving the discriminability of the networks to extract better embeddings for performances improvement. However, only few research focus on improving the generalization. In this paper, we propose to apply the ladder network framework in the SV systems, which combines the supervised and unsupervised learning fashions. The ladder network can make the system to have better high-level embedding by balancing the trade-off to keep/discard as much useful/useless information as possible. We evaluated the framework on two state-of-the-art SV systems, d-vector and x-vector, which can be used for different use cases. The experiments showed that the proposed approach relatively improved the performance by 10% at most without adding parameters and augmented data.
Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay (2015)

Skeletal muscle satellite cells in their niche are quiescent and upon muscle injury, exit quiescence, proliferate to repair muscle tissue, and self-renew to replenish the satellite cell population. To understand the mechanisms involved in maintaining satellite cell quiescence, we identified gene transcripts that were differentially expressed during satellite cell activation following muscle injury. Transcripts encoding RNA binding proteins were among the most significantly changed and included the mRNA decay factor Tristetraprolin. Tristetraprolin promotes the decay of MyoD mRNA, which encodes a transcriptional regulator of myogenic commitment, via binding to the MyoD mRNA 3' untranslated region. Upon satellite cell activation, p38α/β MAPK phosphorylates MAPKAP2 and inactivates Tristetraprolin, stabilizing MyoD mRNA. Satellite cell specific knockdown of Tristetraprolin precociously activates satellite cells in vivo, enabling MyoD accumulation, differentiation and cell fusion into myofibers. Regulation of mRNAs by Tristetraprolin appears to function as one of several critical post-transcriptional regulatory mechanisms controlling satellite cell homeostasis.
Subharmonic analysis using singular-value decomposition of ultrasound contrast agents (2009)

Ultrasound contrast agents (UCAs) are designed to be used below 10 MHz, but interest is growing in studying the response of agents to high-frequency ultrasound. In this study, the subharmonic response of polymer-shelled UCAs with a mean diameter of 1.1 mum excited with 40-MHz tone-bursts of 1-20 cycles was analyzed. UCAs were diluted in water and streamed through a flow phantom that permitted single-bubble backscatter events to be acquired at peak-negative pressures from 0.75 to 5.0 MPa. At each exposure condition, 1000 single-bubble-backscatter events were digitized. Subharmonic content at 20 MHz was screened using a conventional and a singular-value-decomposition (SVD) method. The conventional method evaluated each event spectrum individually while the SVD method treated the 1000-event data set at one time. A subharmonic score (SHS) indicative of how much subharmonic content a 1000-event data set contained was computed for both methods. Empirical-simulation results indicated that SHSs obtained from the two methods were linearly related. Also, experimental data with both methods indicated that subharmonic likelihood increased with pulse duration and peaked near 2 MPa. The SVD method also yielded quantitative information about subharmonic events not available with the conventional method.
High-Resolution Axonal Bundle (Fascicle) Assessment and Triple-Echo Steady-State T2 Mapping of the Median Nerve at 7 T (2016)

This study shows the possibility of fascicle determination of the median nerve in healthy volunteers and patients with CTS (although probably less accurately) with high-resolution 7 T magnetic resonance imaging, as well as significantly higher T2 values in patients with CTS, which seems to be associated with pathophysiological nerve changes.
Hybrid-MAC Model for CAPWAP (2013)

The CAPWAP protocol supports two modes of operation: Split and Local
MAC (medium access control), which has been described in
[RFC5415].There are many functions in IEEE 802l.11 MAC layer that have
not yet been clearly defined whether they belong to either the AP
(Access Point) or the AC (Access Controller)in the Split and Local
modes. Because different vendors have their own definition of these
two models, depending upon the vendor many MAC layer functions
continue to be mapped differently to either the AP or AC. If there is
no clear definition of split MAC and local MAC, then operators will
not only need to perform vendor specific configurations in their
network but will continue to experience difficulty in interoperating
APs and ACs from different vendors.
Innovative Chip Set for Pressure and Acceleration Based Airbag Solutions (2004)

&lt;div class="htmlview paragraph"&gt;More and more passenger cars are equipped with passive side protection systems such as thorax airbags for front and rear passengers. In the past, side airbag protection systems used sensors based on acceleration measurements [&lt;span class="xref"&gt;1&lt;/span&gt;]. In the meantime different sensor principles have been tested in order to increase the performance of this application. The intention has been to achieve faster firing decisions and to decrease the misuse risk for a floor or chassis impact. This paper presents the partitioning of an advanced chipset for pressure and acceleration based airbag systems. It shows the communication link between the sensors, the receiver-IC and other blocks in the application.&lt;/div&gt;
12.7 A 0.85V 600nW all-CMOS temperature sensor with an inaccuracy of &#x00B1;0.4&#x00B0;C (3&#x03C3;) from &#x2212;40 to 125&#x00B0;C (2014)

This paper describes an all-CMOS temperature sensor intended for RFID applications that achieves both sub-1V operation and high accuracy (±0.4°C) over a wide temperature range (-40 to 125°C). It is also an ultra-low-power design: drawing 700nA from a 0.85V supply. This is achieved by the use of dynamic threshold MOSTs (DTMOSTs) as temperature-sensing devices, which are then read out by an inverter-based 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> -order zoom ADC. Circuit errors are mitigated by the use of dynamic error-correction techniques, while DTMOST spread is reduced by a single room temperature (RT) trim. The latter feature constitutes a significant advance over previous all-CMOS designs [5,6], which require two-point trimming to approach the same level of accuracy.
Security and safety of assets in business processes (2012)

Business processes and service compositions are defined independent of the realizing systems. The visualization of security and safety constraints on the business process model level appears to be a promising approach to system independent specification of the security and safety requirements. Such requirements can be realized through business process annotation and used for communication or documentation, but they also can have an execution semantics that allows for automating the security and safety controls.
ChemInform Abstract: Phebaloparvilactone: A New Protolimonoid from the Leaves of Phebalium squamulosum ssp. parvifolium. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Influence of somatostatin on splanchnic glucose metabolism in postabsorptive and 60-hour fasted humans. (1977)

Cyclic somatostatin was administered intravenously (10 mug/min for 60 min) to 10 healthy overnight fasted (postabsorptive) subjects and to 5 healthy 60-h fasted subjects. In both groups, arterial insulin and glucagon fell 50% and splanchnic release of these hormones was inhibited. In the overnight fasted subjects splanchnic glucose output fell 70%, splanchnic uptake of lactate and pyruvate was unchanged, alanine uptake fell by 25%, and glycerol uptake rose more than twofold in parallel with an increase in arterial glycerol. In the 60-h fasted group splanchnic glucose output was less than 40% of that observed in the overnight fasted subjects. Somatostatin led to a further decrease (--70%) in glucose production. Splanchnic uptake of lactate and pyruvate fell by 30-40%, amino acid uptake was unchanged, while uptake of glycerol rose fivefold. Total uptake of glucose precursors thus exceeded the simultaneous glucose output by more than 200%. Splanchnic uptake of FFA rose fourfold during somatostatin while output of beta-hydroxybutyrate increased by 75%. Estimated hepatic blood flow fell 25-35% and returned to base line as soon as the somatostatin infusion ended. It is concluded that (a) somatostatin-induced hypoglucagonemia results in inhibition of splanchnic glucose output in glycogen-depleted, 60-h fasted subjects as well as in postabsorptive subjects, indicating an effect of glucagon on hepatic gluconeogenesis as well as glycogenolysis; (b) the glucagonsensitive step(s) in gluconeogenesis affected by somatostatin involves primarily intra-hepatic disposal rather than net hepatic uptake of glucose precursors; (c) splanchnic uptake of fatty acids and ketone output are increased in the face of combined insulin and glucagon deficiency; and (d) diminished splanchnic blood flow may contribute to some of the effects of somatostatin on splanchnic metabolism.
Over 100x Faster Bootstrapping in Fully Homomorphic Encryption through Memory-centric Optimization with GPUs (2021)

Fully Homomorphic encryption (FHE) has been gaining in popularity as an emerging means of enabling an unlimited number of operations in an encrypted message without decryption. A major drawback of FHE is its high computational cost. Specifically, a bootstrapping step that refreshes the noise accumulated through consequent FHE operations on the ciphertext can even take minutes of time. This significantly limits the practical use of FHE in numerous real applications.By exploiting the massive parallelism available in FHE, we demonstrate the first instance of the implementation of a GPU for bootstrapping CKKS, one of the most promising FHE schemes supporting the arithmetic of approximate numbers. Through analyzing CKKS operations, we discover that the major performance bottleneck is their high main-memory bandwidth requirement, which is exacerbated by leveraging existing optimizations targeted to reduce the required computation. These observations motivate us to utilize memory-centric optimizations such as kernel fusion and reordering primary functions extensively.Our GPU implementation shows a 7.02× speedup for a single CKKS multiplication compared to the state-of-the-art GPU implementation and an amortized bootstrapping time of 0.423us per bit, which corresponds to a speedup of 257× over a single-threaded CPU implementation. By applying this to logistic regression model training, we achieved a 40.0× speedup compared to the previous 8-thread CPU implementation with the same data.
Executive functions in frontotemporal dementia and Lewy body dementia. (2009)

Diagnosis of different types of dementia is often based on clinical symptomatology rather than underlying pathology; therefore, accurate diagnosis depends on a thorough description of cognitive functioning in different dementias. Furthermore, direct comparison of cognitive functions between different types of dementia is necessary for differential diagnosis. Executive dysfunction is common in several types of dementia, including frontotemporal dementia (FTD) and Lewy body dementia (LBD); however, FTD and LBD patients have never been directly compared on measures of executive functioning. The authors compared the performance of 17 FTD and 15 LBD patients on 6 measures of executive functioning in terms of statistical group differences, mean severity of clinical impairment in comparison to normal controls, and frequency of impairment. Results indicated a remarkably similar pattern of performance across all areas examined in terms of mean performance, as well as degree and frequency of impairment. Only the Stroop test produced results that could potentially differentiate the patient groups. These findings suggest that both FTD and LBD should be considered disorders involving executive dysfunction.
Detection of live breast cancer cells in bright-field microscopy images containing white blood cells by image analysis and deep learning (2022)

CNN-based DL approaches could be potentially applied to detect patient-derived CTCs from images of blood samples.
MP69-04 SINGLE POSITIVE LYMPH NODE PROSTATE CANCER CAN BE SURGICALLY CURED IN SELECTIVE CASES (2016)

RESULTS: Mean (median) number of removed LNs was 15.0 (13) and mean (median) number of positive LNs was 2.4 (1). In multivariate analysis, the number of removed LNs did not significantly influence oncologic outcomes (BCR, MFS, CSM), neither when used as a continuous nor as a dichotomous variable. Occurrence of metastasis and cancer-specific mortality significantly increased with higher number of positive lymph nodes.
1F7, a novel cell surface molecule, involved in helper function of CD4 cells. (1989)

Abstract We have developed a monoclonal antibody, anti-1F7, that inhibits soluble Ag-driven T cell proliferation as well as PWM-driven IgG synthesis. Anti-1F7 antibody reacts with approximately 57% of unfractionated T cells, 62% of CD4+ cells, and 54% of CD8+ cells. Although the 1F7 Ag is widely distributed among lymphoid cells, this Ag on CD4+ cells is preferentially expressed on the CDw29(4B4+) helper population. Moreover, anti-1F7 antibody further subdivides the CD4+CDw29+ cell subset into CDw29+1F7+ and CDw29+1F7- populations. The CD4+CDw29+1F7+ population of cells maximally proliferates to recall Ag such as tetanus toxoid, whereas helper function for PWM-driven IgG synthesis by B cells belongs to both the CD4+CDw29+1F7+ and CD4+CDw29+1F7- population of cells. The most prominent structure defined by this antibody is a 110-kDa molecule that is different from the 135-kDa, 160-kDa, and 185-kDa glycoproteins identified by anti-CDw29 antibody and the 180-kDa glycoprotein identified by UCHL-1 antibody. It is, however, related to the molecule recognized by anti-Ta1, an activation Ag on T cells. Furthermore, although the Ta1 molecule is recognized by anti-1F7 mAb, the 1F7 family of structures also includes molecules distinct from Ta1.
Hedgehog signaling sensitizes Glioma stem cells to endogenous nano-irradiation (2014)

The existence of therapy resistant glioma stem cells is responsible for the high recurrence rate and incurability of glioblastomas. The Hedgehog pathway activity plays an essential role for self-renewal capacity and survival of glioma stem cells. We examined the potential of the Sonic hedgehog ligand for sensitizing of glioma stem cells to endogenous nano-irradiation. We demonstrate that the Sonic hedgehog ligand preferentially and efficiently activated glioma stem cells to enter the radiation sensitive G2/M phase. Concomitant inhibition of de novo thymidine synthesis with fluorodeoxyuridine and treatment with the Auger electron emitting thymidine analogue 5-[I-125]-Iodo-4'-thio-2'-deoxyuridine ([I-125]ITdU) leads to a fatal nano-irradiation in sensitized glioma stem cells. Targeting of proliferating glioma stem cells with DNA-incorporated [I-125]ITdU efficiently invokes the intrinsic apoptotic pathway despite active DNA repair mechanisms. Further, [I-125]ITdU completely inhibits survival of glioma stem cells in vitro. Analysis of non-stem glioblastoma cells and normal human astrocytes reveals that glioma stem cells differentially respond to Sonic hedgehog ligand. These data demonstrate a highly efficient and controllable single-cell kill therapeutic model for targeting glioma stem cells.
Exquisite textiles sensors and wireless sensor network device for home health care (2008)

In this study, we propose a wearing system with four sensors, ECG (electrocardiogram), three-axis accelerometer, temperature, and tight-switch, applied for remote monitoring system in home-care. The sensors ECG, measured with wearable electrodes made of the steel textile to generate the real-time heart-rate estimator, tight-switch, made of the steel textile to check whether wearing person dresses properly, accelerometer, and temperature parameters are received via the ZigBee receiver within an exquisite belt. Since the movable textile electrodes will cause of unfixed contacts when the wearing person is in motion, making the heart-rate estimation much a sophisticated work, the tight-switch sensor and FIR (Filter Impulse Response) filter technology are applied here to get the more satisfiable heart-rate. The other two bio-sensors can detect the whether fall-down or not and normal body-temperature of this wearing person. Moreover, the ZigBee device with small size, low-power consumption, and high-reliability characteristics is designed to transmit the detected bio-information from these four sensors. Therefore, the vital system embedded with the capability of real-time heart-rate estimation and transmission makes it highly suitable for applications of remote healthcare and wellness.
Interleukin-8 (IL-8), Melanoma Growth-stimulatory Activity, and Neutrophil-activating Peptide Selectively Mediate Priming of the Neutrophil NADPH Oxidase through the Type A or Type B IL-8 Receptor (1996)

The capacity of neutrophils to generate superoxide (O-2) can be enhanced by prior exposure to "priming" agents such as interleukin-8 (IL-8), melanoma growth-stimulatory activity (MGSA), and neutrophil-activating peptide (ENA-78). The biological effects of these chemokines are mediated by at least two distinct receptors: type A (IL-8-RA) and type B (IL-8-RB). Using neutralizing monoclonal antibodies to IL-8-RA and IL-8-RB, we have investigated the contribution each receptor makes to the priming response. Preincubation with IL-8, MGSA, or ENA-78 enhanced the ability of neutrophils to generate O-2 following stimulation with the bacterial peptide formyl-Met-Leu-Phe. The priming effect of IL-8 was eliminated by an anti-IL-8 monoclonal antibody (mAb) that is known to bind IL-8 with high affinity and prevent receptor occupancy. Incubation of neutrophils with a neutralizing mAb specific for IL-8-RA blocked IL-8-induced priming but had no effect on priming by MGSA or ENA-78. In contrast, treatment with a neutralizing mAb specific for IL-8-RB failed to inhibit the priming effect of IL-8 but blocked both MGSA and ENA-78-induced priming. These observations indicate that the priming effect of IL-8 on the neutrophil respiratory burst is predominantly mediated via IL-8-RA, whereas priming by MGSA and ENA-78 is mediated by IL-8-RB.