gebhart/patrepeval huggingface dataset:
Integrated Lateral and Roll Stability Control of Multi-Actuated Vehicles Using Prioritization Model Predictive Control (2022)

This paper presents a prioritization model predictive control for integrated lateral and roll stability control of all-wheel-drive vehicles. The vehicle’s powertrain includes an electric motor and an open differential per axle, which enables generating a corrective yaw moment by front/rear torque shifting. In addition, the brakes can be used in differential mode to further enhance the corrective yaw moment when needed. To ensure vehicle stability, safety limits are defined on the vehicle’s yaw rate, sideslip, and roll motions, considering road angle effects. The controller prioritizes the control actions and objectives based on, respectively, their advantages and their importance, and then combines the priorities such that differential braking, which is defined as the low priority actuation, will not kick in unless the stability limits are violated. The performance of the designed controller is thoroughly evaluated through numerical and full vehicle experimental studies in different driving scenarios on flat and non-flat roads.
Histotripsy for Pediatric Cardiac Applications: In Vivo Neonatal Pig Model (2010)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Ryan M. Miller, Gabe Owens, Gregory Ensing, Achiau Ludomirsky, Charles Cain, Zhen Xu; Histotripsy for Pediatric Cardiac Applications: In Vivo Neonatal Pig Model. AIP Conf. Proc. 9 March 2010; 1215 (1): 15–18. https://doi.org/10.1063/1.3367130 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Far-field investigation of slow-light propagating below the light cone in planar photonic structures (2007)

A far-field technique is used to investigate the properties of optical waves propagating below the light cone in nanophotonic structures. As an example, dispersion curves for slow-light in photonic crystal waveguides are retrieved.
GNSS Threat Monitoring and Reporting with the Android Raw GNSS Measurements and STRIKE3 (2019)

Reliable radio navigation signals are of extreme importance. Nowadays, we rely on Global Navigation Satellite System (GNSS) related technologies for an array of uses ranging from agricultural, financial, transportation, and military applications. As such, providing existing systems with the tools to combat the threat presented by malicious spoofing or jamming attacks is critical. The paper, by adequately assessing fundamental measurements offered in the raw GNSS engine, and using software tools native to the Android Operating System (OS), will show the effectiveness of Android devices in reporting interference events as per the Standardization of GNSS Threat Reporting and Receiver Testing through International Knowledge Exchange, Experimentation and Exploitation (STRIKE3) Threat Monitoring and Reporting standard. This work also proposes noninvasive improvements to the aforementioned standard that aim to improve the reporting procedures, extend the support for non-GPS signals, and increase support for smartphones. Finally, this work also presents a detailed study of the infrastructure required to reproduce the findings of this work in terms of bandwidth, server costs, and false alarm consideration due to user dynamics.
Superconducting Optoelectronic Neurons I: General Principles (2018)

The design of neural hardware is informed by the prominence of differentiated processing and information integration in cognitive systems. The central role of communication leads to the principal assumption of the hardware platform: signals between neurons should be optical to enable fanout and communication with minimal delay. The requirement of energy efficiency leads to the utilization of superconducting detectors to receive single-photon signals. We discuss the potential of superconducting optoelectronic hardware to achieve the spatial and temporal information integration advantageous for cognitive processing, and we consider physical scaling limits based on light-speed communication. We introduce the superconducting optoelectronic neurons and networks that are the subject of the subsequent papers in this series.
Simultaneous Retzius-sparing robot-assisted radical prostatectomy and partial nephrectomy (2016)

We present a 61-year-old man who was diagnosed with synchronous prostate cancer and suspicious renal cell carcinoma of the right kidney, treated with combined Retzius-sparing robot-assisted radical prostatectomy (RS-RARP) and robot-assisted partial nephrectomy (RAPN). The combined approach using RS-RARP and RAPN is technically feasible and safe surgical option for treatment of concomitant prostate cancer and suspicious renal cell carcinoma.
Factors Associated with Improved Survival in Patients with Brain Metastases from Esophageal Cancer: A Retrospective Review (2003)

There are over 200,000 cases of brain metastases (BrM) every year, but very few are from esophageal cancer primaries. In order to determine predictors for outcome of these patients, the authors conducted a retrospective review of twenty-seven patients with BrM from esophageal carcinoma diagnosed at the Cleveland Clinic Foundation between 1991 and 2001. For the entire cohort, median follow-up and median survival was 3.6 months and 3.6 months, respectively. On univariate analysis, patients with Karnofsky Performance Status (KPS) >/= 70, low recursive partitioning analysis score, single BrM, no systemic disease, and aggressive treatment [surgery, stereotactic radiosurgery (SRS) + whole brain radiation (WBRT), SRS + surgery + WBRT, surgery + WBRT)] had a significantly improved survival. In a multivariate model, patients with higher KPS and aggressive treatment had improved survival. The 1-year survival for the WBRT alone group and the aggressive treatment group was 6%, and 36% respectively. We conclude that based on the data presented here, patients with BrM from esophageal cancer have poor outcome. Aggressive treatment and favorable KPS are associated with longer survival for selected patients. We recommend esophageal cancer patients with BrM be enrolled in clinical trials to better delineate the role of treatment and potentially improve results.
Effect of Shot Peening on Torsional Fatigue Strength of High Strength Spring Steel and Prediction of Fatigue Strength (2009)

Torsional fatigue tests were conducted for a spring steel, SUP7, with Vickers hardness of 480. The effect of shot peening on the torsional fatigue strength of smooth and artificially notched specimens in the corrosive environment and air was studied. Following results were obtained. The increase of the fatigue strength of smooth specimens in air by shot peening was relatively small, and the surface roughness due to peening did not reduced the fatigue strength. On the other hand, the fatigue strength of notched specimens increased greatly by shot peening and the notch sensitivity was reduced. In corrosion fatigue, the fatigue strength increased by shot peening in the medium life range, around 106 cycles. The strength of shot-peened specimens was reduced in the long life range around 107 cycles and was approached to that of not-peened specimens. A similar improvement was observed for notched specimens in the medium life range, and the notch sensitivity was reduced by shot peening. The compressive residual stress layer made by shot peening extended about 0.3 mm below the surface, and relaxed by fatigue loading. The residual stress distribution was used to interpret the effect of shot peening on the fatigue strength of spring steel by modified Goodman diagram.
Data-driven child behavior prediction system based on posture database for fall accident prevention in a daily living space (2020)

Abstract Ten thousand children are admitted to emergency rooms due to accidents every year in Tokyo. The most frequent accident is a fall accident. Fall accidents may occur when climbing to a high place in a daily living space. Since injury prevention by human supervision does not work well, the World Health Organization recommends an environmental modification approach as an effective preventive countermeasure to this problem. Predicting children’s behavior is necessary in order to improve the environment. However, even for advanced human modeling technology, predicting where children can climb in everyday life situations remains difficult. In the present study, the authors developed a new method for predicting places that children can climb in a data-driven manner by integrating cameras, a behavior recognition system (OpenPose), and a climbing motion planning algorithm based on a rapidly exploring random tree. Thirty five children participated in an experiment to collect climbing posture data. A simulation is performed based on the posture database and allows us to visually understand how children climb up in daily living space. This makes it possible to improve to achieve a safe environment for children without the need for specialized knowledge, which is useful for parents, nursery teachers, nurses, etc. The present paper describes fundamental functions of the developed system and presents an evaluation of the feasibility of the prediction function.
Biochemical Properties and Colony Formation Patterns of Salmonella-Like Strains. (1997)

Five bacterial strains were isolated from food samples, and were not easily distinguished from Salmonella via conventional methods. These bacterial strains wereidentified as Citrobacter spp. from their biochemical properties. Despite this, their characteristics after being cultured resembled those of Salmonella, with similar kinds of colony formation patterns on XLD, DHL and TSI agar. Since these salmonella-like strains grew at a rate and produced colonies with black centers characteristic of Salmonella, the selective detection of Salmonella in the presence of these salmonella-like strains was impossible, based on conventional methods.
Colony-Stimulating Factors Signal for Increased Transport of Vitamin C in Human Host Defense Cells (1998)

Although serum concentrations of ascorbic acid seldom exceed 150 micromol/L, mature neutrophils and mononuclear phagocytes accumulate millimolar concentrations of vitamin C. Relatively little is known about the mechanisms regulating this process. The colony-stimulating factors (CSFs), which are central modulators of the production, maturation, and function of human granulocytes and mononuclear phagocytes, are known to stimulate increased glucose uptake in target cells. We show here that vitamin C uptake in neutrophils, monocytes, and a neutrophilic HL-60 cell line is enhanced by the CSFs. Hexose uptake studies and competition analyses showed that dehydroascorbic acid is taken up by these cells through facilitative glucose transporters. Human monocytes were found to have a greater capacity to take up dehydroascorbic acid than neutrophils, related to more facilitative glucose transporters on the monocyte cell membrane. Ascorbic acid was not transported by these myeloid cells, indicating that they do not express a sodium-ascorbate cotransporter. Granulocyte (G)- and granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulated increased uptake of vitamin C in human neutrophils, monocytes, and HL-60 neutrophils. In HL-60 neutrophils, GM-CSF increased both the transport of dehydroascorbic acid and the intracellular accumulation of ascorbic acid. The increase in transport was related to a decrease in Km for transport of dehydroascorbic acid without a change in Vmax. Increased ascorbic acid accumulation was a secondary effect of increased transport. Triggering the neutrophils with the peptide fMetLeuPhe led to enhanced vitamin C uptake by increasing the oxidation of ascorbic acid to the transportable moiety dehydroascorbic acid, and this effect was increased by priming the cells with GM-CSF. Thus, the CSFs act at least at two distinct functional loci to increase cellular vitamin C uptake: conversion of ascorbic acid to dehydroascorbic acid by enhanced oxidation in the pericellular milieu and increased transport of DHA through the facilitative glucose transporters at the cell membrane. These results link the regulated uptake of vitamin C in human host defense cells to the action of CSFs.
Automatic diet monitoring: a review of computer vision and wearable sensor-based methods (2017)

Food intake and eating habits have a significant impact on people's health. Widespread diseases, such as diabetes and obesity, are directly related to eating habits. Therefore, monitoring diet can be a substantial base for developing methods and services to promote healthy lifestyle and improve personal and national health economy. Studies have demonstrated that manual reporting of food intake is inaccurate and often impractical. Thus, several methods have been proposed to automate the process. This article reviews the most relevant and recent researches on automatic diet monitoring, discussing their strengths and weaknesses. In particular, the article reviews two approaches to this problem, accounting for most of the work in the area. The first approach is based on image analysis and aims at extracting information about food content automatically from food images. The second one relies on wearable sensors and has the detection of eating behaviours as its main goal.
The formation of SGOI structures with low dislocation density by a two-step oxidation and condensation method (2006)

A modified process of the Ge condensation method, which is a technique to form SiGe on insulator (SGOI) substrates for strained SOI-MOSFETs, is proposed to reduce threading dislocation density and the effectiveness of the proposed technique is demonstrated. The generation of threading dislocations, which is attributable to the rising behaviour of fragments of misfit dislocations formed at the SiGe/SOI interfaces, is suppressed by controlling the oxygen pressure during the ramping up period in the Ge condensation process. The threading dislocation density of SGOI substrates formed by the new method, which is evaluated by the enhanced secco-etching method, has been as low as 1 × 103 cm−2 for the 230 nm thick SGOI layer with a Ge content of 20% and 75% relaxation.
Tracheal cytotoxin structural requirements for respiratory epithelial damage in pertussis (1995)

The respiratory epithelial pathology of pertussis (whooping cough) can be reproduced by tracheal cytotoxin (TCT), a disaccharide-tetrapeptide released by Bordetella pertussis. TCT is a muramyl peptide, a class of peptidoglycan-derived compounds which have many biological activities including adjuvanticity, somnogenicity, pyrogenicity, and cytotoxicity. The structural requirements for muramyl peptides to produce some of these biological effects have been partially characterized. Using in vitro assays with respiratory epithelial cells and tissue, we have previously determined that the disaccharide moiety of TCT is not involved in toxicity and that the side-chain functional groups of diaminopimelic acid (A2pm) are crucial for toxicity. In this study, we determine the importance of every amino acid, functional group and chiral centre in the peptide portion of TCT. Although lactyl tetrapeptides are the most toxic of the TCT fragments, producing dose-response curves identical to TCT, the smallest analogues of TCT which are active in our assay are of the form X-gamma-(D)-Glu-meso-A2pm, where X may be an amino acid or a blocking group. Within this active substructure, main-chain chirality and all functional groups are essential for toxicity. This definition of the core region of TCT indicates that the TCT interaction site is unlike almost all other muramyl peptide interaction sites for which structure-activity data are available.
Photonics in computing: Interconnects and beyond (2006)

With the advent of VCSELs, optical interconnects became pratical for machine-to- machine communication and may soon penetrate inside the machine all the way to chip- to-chip communication. This presentation will review the progress made so far to assess future research directions and hallenges of photonics in computing.
Molecular Cloning and Characterization ofrpbAEncoding RNA Polymerase II Largest Subunit from a Filamentous Fungus,Aspergillus oryzae (2000)

We have cloned rpbA encoding the RNA polymerase II largest subunit (polIIL) from a filamentous fungus, Aspergillus oryzae. The rpbA product included eight highly conserved regions and the carboxyl-terminal domain (CTD). A. oryzae polIIL CTD with 184 amino acids was composed of 25 CTD consensus repeats, which was a similar number to those of lower eukaryotes. The amino acids in each repeat of A. oryzae polIIL, however, conformed less to the CTD consensus than those of polIILs from other lower eukaryotes.
Safety, Tolerability, Pharmacokinetics, and Drug Interaction Potential of SPR741, an Intravenous Potentiator, after Single and Multiple Ascending Doses and When Combined with β-Lactam Antibiotics in Healthy Subjects (2019)

SPR741 is a novel polymyxin B derivative, with minimal intrinsic antibacterial activity and reduced nonclinical nephrotoxicity compared to levels with polymyxin B, that interacts with the outer membrane of Gram-negative bacteria, enhancing penetration of coadministered antibiotics. The safety, tolerability, and pharmacokinetics (PK) of SPR741 were evaluated in two studies, after single and multiple intravenous (i.v.) doses in healthy adult subjects and after coadministration with partner antibiotics. In the single and multiple ascending-dose study, SPR741 or placebo was administered as a 1-h infusion at single doses of 5 to 800 mg and in multiple doses of 50 to 600 mg every 8 h (q8h) for 14 days. In the drug-drug interaction study, a single 400-mg i.v. dose of SPR741 was administered alone and in combination with piperacillin-tazobactam, ceftazidime, and aztreonam. PK parameters for SPR741 and partner antibiotics were determined using noncompartmental analysis. After single doses, a dose-linear and proportional increase in mean maximum concentration in plasma (<i>C</i><sub>max</sub>) and area under the concentration-time curve (AUC) was observed. At doses of 100 to 800 mg, >50% of the dose was excreted in the urine in the first 4 h postdose. After multiple doses, the mean half-life was 2.2 h on day 1 and up to 14.0 h on day 14, with no evidence of accumulation after 14 days of dosing up to 400 mg. The PK profile of SPR741 and partner antibiotics was unchanged with coadministration. SPR741 was generally well tolerated at doses up to 1,800 mg/day. These data support further clinical development of SPR741 for treating serious infections due to resistant bacteria. (These studies have been registered at ClinicalTrials.gov under identifiers NCT03022175 and NCT03376529.).
Innate Retroviral Restriction by Apobec3 Promotes Antibody Affinity Maturation In Vivo (2010)

Apobec3/Rfv3 is an innate immune factor that promotes the neutralizing Ab response against Friend retrovirus (FV) in infected mice. Based on its evolutionary relationship to activation-induced deaminase, Apobec3 might directly influence Ab class switching and affinity maturation independently of viral infection. Alternatively, the antiviral activity of Apobec3 may indirectly influence neutralizing Ab responses by reducing early FV-induced pathology in critical immune compartments. To distinguish between these possibilities, we immunized wild-type and Apobec3-deficient C57BL/6 (B6) mice with (4-hydroxy-3-nitrophenyl) acetyl (NP) hapten and evaluated the binding affinity of the resultant NP-specific Abs. These studies revealed similar affinity maturation of NP-specific IgG1 Abs between wild-type and Apobec3-deficient mice in the absence of FV infection. In contrast, hapten-specific Ab affinity maturation was significantly compromised in Apobec3-deficient mice infected with FV. In highly susceptible (B6 x A.BY)F(1) mice, the B6 Apobec3 gene protected multiple cell types in the bone marrow and spleen from acute FV infection, including erythroid, B, T, and myeloid cells. In addition, B6 Apobec3 deficiency was associated with elevated Ig levels, but decreased induction of splenic germinal center B cells and plasmablasts during acute FV infection. These data suggest that Apobec3 indirectly influences FV-specific neutralizing Ab responses by reducing virus-induced immune dysfunction. These findings raise the possibility that enabling Apobec3 activity during acute infection with human pathogenic retroviruses, such as HIV-1, may similarly facilitate stronger virus-specific neutralizing Ab responses.
Wind turbine blade deflection sensing system based on UWB technology (2016)

A microwave sensing system for estimating deflection of a wind turbine blade is presented. The system measures distances at mo ultrawideband (UWB) wireless links between one antenna at the tip and two antennas at the root of the blade, which allows for determination of the tip position by triangulation. An experimental setup with corner reflector antenna mounted at the tip and horn antennas at the root of a 37.3 m long blade is described. Analyzing the data from the experiment, special attention is given to the propagation aspects of the VWB links, with focus on the multipath effects caused by the blade. It is demonstrated that despite the adverse effects of the multipath propagation the ranging accuracy of the system amounts to 1.5 cm, leading to maximum error of deflection 4.5 %.
ChemInform Abstract: Synthesis of Indolo(2,3‐a)quinolizine Alkaloids via Nucleophilic Additions of Metalated Pyridines. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Toll-like receptor agonist therapy augments the antitumor activity of adoptively transferred CD8+ T cells without host preconditioning (2016)

Abstract Lymphodepletion enhances adoptive T cell transfer (ACT) therapy by activating the innate immune system via microbes released from the radiation-injured gut. Microbial LPS is a key mediator of lymphodepletion enhancement, but our ability to use these TLR agonists to bolster the potency of T cell-based cancer therapies remains elusive. Herein, we used LPS as a tool to address how and when to use TLR agonists to improve cancer immunotherapy. We utilized the pmel-1 melanoma mouse model. B16F10-bearing mice were lymphodepleted with 5Gy total body irradiation (TBI) and given a tripartite ACT therapy (consisting of transferred pmel-1 CD8+ T cells, vaccination with fowlpox encoding gp100, and IL-2) along with TLR4 agonist LPS. The timing of LPS administration and the requirement of individual components of the tripartite therapy were evaluated. We discovered that while exogenous administration of LPS was able to enhance CD8+ T cells’ tumor destruction, LPS treatment alone did not replace individual components of the tripartite regimen. Interestingly, administering LPS one day before ACT compromised tumor regression. Conversely, administering LPS after ACT potentiated the antitumor effectiveness of the regimen, thereby supporting the expansion of transferred CD8+ T cells over host Treg cells. Non-toxic TLR agonists MPL and CpG also improved ACT therapy. Finally, TBI preconditioning was no longer needed to regress tumors in mice depleted of host CD4+ T cells, given a tripartite ACT regimen and then treated with a TLR agonist. Collectively, our results identify how and when to administer TLR agonists to augment ACT in the absence of host preconditioning. These findings have implications for the design of next generation T cell therapies.