gebhart/patrepeval huggingface dataset:
A potent IκB kinase‐β inhibitor labeled with carbon‐14 and deuterium (2016)

3-Amino-4-(1,1-difluoro-propyl)-6-(4-methanesulfonyl-piperidin-1-yl)-thieno[2,3-b]pyridine-2-carboxylic acid amide (1) is a potent IκB Kinase-β (IKK-β) inhibitor. The efficient preparations of this compound labeled with carbon-14 and deuterium are described. The carbon-14 synthesis was accomplished in six radiochemical steps in 25% overall yield. The key transformations were the modified Guareschi-Thorpe condensation of 2-cyano-(14) C-acetamide and a keto-ester followed by chlorination to 2,6-dichloropyridine derivative in one pot. The isolated dichloropyridine was then converted in three steps in one pot to [(14) C]-(1). The carbon-14 labeled (1) was isolated with a specific activity of 54.3 mCi/mmol and radiochemical purity of 99.8%. The deuterium labeled (1) was obtained in eight steps and in 57% overall chemical yield using 4-hydroxypiperidine-2,2,3,3,4,5,5,6,6-(2) H9 . The final three steps of this synthesis were run in one pot.
Optimized Design of High-Efficiency Immittance Matching Networks for Capacitive Wireless Power Transfer Systems (2021)

This paper introduces an analytical approach to optimize the design of immittance matching networks that provide gain and reactive compensation in capacitive wireless power transfer (WPT) systems while maintaining load-independent output current. The proposed approach maximizes the matching network efficiency by identifying the optimal number of matching network stages, and by optimally distributing the overall gain among these stages. Compared to the conventional approach to designing immittance matching networks in capacitive WPT systems, the proposed approach is shown to achieve 82% smaller losses. A 6.78-MHz capacitive WPT prototype utilizing immittance matching networks is designed and built, and the measured network efficiency is shown to match well with analytical predictions.
Data from A Comparative Study of Neuroendocrine Heterogeneity in Small Cell Lung Cancer and Neuroblastoma (2023)

&lt;div&gt;Abstract&lt;p&gt;Lineage plasticity has long been documented in both small cell lung cancer (SCLC) and neuroblastoma, two clinically distinct neuroendocrine (NE) cancers. In this study, we quantified the NE features of cancer as NE scores and performed a systematic comparison of SCLC and neuroblastoma. We found neuroblastoma and SCLC cell lines have highly similar molecular profiles and shared therapeutic sensitivity. In addition, NE heterogeneity was observed at both the inter- and intra-cell line levels. Surprisingly, we did not find a significant association between NE scores and overall survival in SCLC or neuroblastoma. We described many shared and unique NE score–associated features between SCLC and neuroblastoma, including dysregulation of Myc oncogenes, alterations in protein expression, metabolism, drug resistance, and selective gene dependencies.&lt;/p&gt;Implications:&lt;p&gt;Our work establishes a reference for molecular changes and vulnerabilities associated with NE to non-NE transdifferentiation through mutual validation of SCLC and neuroblastoma samples.&lt;/p&gt;&lt;/div&gt;
Clinical review: Practical recommendations on the management of perioperative heart failure in cardiac surgery (2010)

Acute cardiovascular dysfunction occurs perioperatively in more than 20% of cardiosurgical patients, yet current acute heart failure (HF) classification is not applicable to this period. Indicators of major perioperative risk include unstable coronary syndromes, decompensated HF, significant arrhythmias and valvular disease. Clinical risk factors include history of heart disease, compensated HF, cerebrovascular disease, presence of diabetes mellitus, renal insufficiency and high-risk surgery. EuroSCORE reliably predicts perioperative cardiovascular alteration in patients aged less than 80 years. Preoperative B-type natriuretic peptide level is an additional risk stratification factor. Aggressively preserving heart function during cardiosurgery is a major goal. Volatile anaesthetics and levosimendan seem to be promising cardioprotective agents, but large trials are still needed to assess the best cardioprotective agent(s) and optimal protocol(s). The aim of monitoring is early detection and assessment of mechanisms of perioperative cardiovascular dysfunction. Ideally, volume status should be assessed by 'dynamic' measurement of haemodynamic parameters. Assess heart function first by echocardiography, then using a pulmonary artery catheter (especially in right heart dysfunction). If volaemia and heart function are in the normal range, cardiovascular dysfunction is very likely related to vascular dysfunction. In treating myocardial dysfunction, consider the following options, either alone or in combination: low-to-moderate doses of dobutamine and epinephrine, milrinone or levosimendan. In vasoplegia-induced hypotension, use norepinephrine to maintain adequate perfusion pressure. Exclude hypovolaemia in patients under vasopressors, through repeated volume assessments. Optimal perioperative use of inotropes/vasopressors in cardiosurgery remains controversial, and further large multinational studies are needed. Cardiosurgical perioperative classification of cardiac impairment should be based on time of occurrence (precardiotomy, failure to wean, postcardiotomy) and haemodynamic severity of the patient's condition (crash and burn, deteriorating fast, stable but inotrope dependent). In heart dysfunction with suspected coronary hypoperfusion, an intra-aortic balloon pump is highly recommended. A ventricular assist device should be considered before end organ dysfunction becomes evident. Extra-corporeal membrane oxygenation is an elegant solution as a bridge to recovery and/or decision making. This paper offers practical recommendations for management of perioperative HF in cardiosurgery based on European experts' opinion. It also emphasizes the need for large surveys and studies to assess the optimal way to manage perioperative HF in cardiac surgery.
Infrared spectra of matrix-isolated species; reaction products of MgF2with group–I and group–II fluorides (1976)

Infrared spectra of MgF2 vapour co-deposited with vapours of alkali metal fluorides, LiF, NaF, KF and CsF and alkaline earth difluorides, CaF2 and SrF2, in argon matrices at liquid helium temperatures are reported in the range 400–1000 cm–1. New frequencies are identified as belonging to mixed fluorides MMgF3 and M′MgF4. The frequencies are tentatively assigned to these species assuming a planar cyclic structure of C2v symmetry. A correlation with the spectrum of the dimer Mg2F4 of D2h symmetry is presented.
MP05-20 HISTOPATHOLOGIC CORRELATION OF PIRADS VERSION 2 LESIONS ON 3T MULTIPARAMETRIC PROSTATE MRI (2016)

You have accessJournal of UrologyImaging/Radiology: Uroradiology I1 Apr 2016MP05-20 HISTOPATHOLOGIC CORRELATION OF PIRADS VERSION 2 LESIONS ON 3T MULTIPARAMETRIC PROSTATE MRI Corinne C. Liu, Kaitlin E. Kosinski, Jeffrey T. Schiff, and Aaron E. Katz Corinne C. LiuCorinne C. Liu More articles by this author , Kaitlin E. KosinskiKaitlin E. Kosinski More articles by this author , Jeffrey T. SchiffJeffrey T. Schiff More articles by this author , and Aaron E. KatzAaron E. Katz More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.1997AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Prostate Imaging Reporting and Data System (PIRADS) Version 2 was recently issued by The American College of Radiology. Each score, from 1 to 5, corresponds to the likelihood of clinically significant cancer. We aim to evaluate the correlation between a higher PIRADS score and the presence of high grade tumor on histopathology. METHODS 300 consecutive 3T Multiparametric Prostate MRI (MP-MRI) were identified from March 26, 2012 to June 29, 2015. We reviewed patient charts and a total of 102 patients underwent either a transrectal ultrasound guided (TRUS) biopsy or a total prostatectomy after the MP-MRI. 34 patients were excluded due to prior radiation or cryoablation to the prostate, leaving 68 treatment naive patients (44 - 84 years). MP-MRIs were re-interpreted utilizing the new PIRADS V.2 scoring system and correlated with pathology findings. Statistical comparisons were made using R (v.3.1.2) and Fisher’s exact test. RESULTS High grade (Gleason 8-10) tumors were found only in MP-MRI with a PIRADS score of 5 and a higher percentage of tumor is found in MP-MRI with PIRADS scores of 4 and 5 (80%) when compared to PIRADS scores of 2 and 3 (32%). Low grade (Gleason 6-7) tumors were also found in both PIRADS 4 and 5 categories. There was a significant relationship between a higher PIRADS score and a finding of cancer on pathology (p = 0.0003, OR=0.118, 95% CI 0.03-0.41). CONCLUSIONS The PIRADS scoring system is a useful tool in suggesting the likelihood of clinically significant cancer, with high grade tumors found only in MP-MRI with a score of PIRADS 5. However, MP-MRI and PIRADS criteria alone are not sufficient for determining clinically significant prostate cancer since both high grade and low grade tumors were found in PIRADS 5 and 4 categories. Correlation with other clinical parameters and biopsy is required for confirmation. A larger scale study would be helpful for further delineation. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e44-e45 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Corinne C. Liu More articles by this author Kaitlin E. Kosinski More articles by this author Jeffrey T. Schiff More articles by this author Aaron E. Katz More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
Questionnaire‐based diagnosis of REM sleep behavior disorder in Parkinson's disease (2013)

A combination of patient and bed-partner questionnaires is a useful tool to detect RBD.
Innovative Technology for Recombinant Protein Production Using Engineered <i>E. coli</i> Genetic Codes (2016)

遺伝子の塩基配列は「遺伝コード」によってアミノ酸配列に翻訳されてタンパク質が生合成される．人工のアミノ酸を組み込んだタンパク質を合成する目的で，大腸菌の遺伝コードの改変が行われている．新規に作製された大腸菌株（RFzero株など）を用いて，組換えタンパク質の複数個所に人工アミノ酸（1種類）を組込むことが既に可能になっている．現在，2種類以上の人工アミノ酸を自由に組込む技術の開発が進められている．
Abstract LB-139: In situ Treg immunomodulation at a single tumor site with CpG and immune checkpoint antibodies cures metastatic disease (2012)

Abstract Background: CD4+CD25+FOXP3+ regulatory T-cells (Tregs) infiltrate all tumor sites and play a central role in maintaining immune tolerance to cancers. Scientific question: Is the local immunomodulation of Tregs from a single tumor site sufficient to trigger a systemic anti-tumor immune response able to eradicate distant tumor sites ≤ Results: We found that tumor infiltrating Tregs preferentially express CTLA4 (CD152) and OX40 (CD134) compared to their counterparts in the blood and other lymphoid organs, both in mice and in human lymphomas. We show in a murine lymphoma model that OX40 and CTLA4 upregulation occurs specifically on Tregs directed against tumor antigens. Injections of low doses of anti-CTLA4 and anti-OX40 together with CpG, a TLR-9 agonist, directly into a single tumor site depletes the Tregs from the injected tumor but not from distant ones. This immunomodulation subsequently triggers an anti-tumor immune response able to cure mice with established disseminated disease. This triple combination is uniquely required as neither CpG alone nor mAbs without CpG are effective. Significance: immunomodulatory antibodies are currently under clinical development for cancer therapy. Their major toxicity is the triggering of auto-immune diseases. We show here that after injections of very little doses of these antibodies with CpG at one tumor site, their serum levels become undetectable. However, these doses are sufficient to trigger a systemic anti-tumor response able to eradicate distant sites. Impact: we recently have published positive results of intra-tumoral CpG in patients with follicular Lymphoma (Brody, Levy, et al. JCO, 2010). Anti-CTLA4 has just been approved by the FDA/EMEA in patients with metastatic melanoma. Anti-Ox40 antibodies are currently being tested in phase I/II clinical trials. Therefore, the combination described here can be tested in patients with injectable sites of lymphoma. Together, these results are in favor of a paradigm shift in cancer therapy where the immune system is targeted rather than the tumor itself. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-139. doi:1538-7445.AM2012-LB-139
User-guided interictal spike detection (2008)

In the diagnosis and treatment of epilepsy, long-term monitoring may be required to document and study interictal activities such as interictal spikes. However, visual inspection of the EEG done by an expert is too time consuming and researchers normally resort to automatic detection methods. We describe a new EEG user-guided interictal spike detection algorithm that only requires the user to annotate a few spikes. We use the annotations to build a template that captures the relevant features of spikes, and then use Mean Squared Error (MSE) test to detect all of the other spikes in the recording. The detected events are rank ordered so that the user can easily identify the true spikes and their time of occurrence. The true spikes are then annotated to the EEG signals and reported to the EEG expert for further evaluation. This design provides a compromise between the enormous time commitments necessary to annotate recordings by hand and the inability of fully-automatic spike detection algorithms to account for the variability between subjects. Because spike morphology and spatial distribution change considerably when patients go through cycles of wake and sleep in long-term monitoring, this detection algorithm uses multichannel multiple templates to detect more than one type of event. The algorithm is able to achieve an average sensitivity of 96% and an average of 4.8 false detections/ hour.
Shaping micro-clusters via inverse jamming and topographic close-packing of microbombs (2017)

Designing topographic clusters is of significant interest, yet it remains challenging as they often lack mobility or deformability. Here we exploit the huge volumetric expansion (up to 3000%) of a new type of building block, thermally expandable microbombs. They consist of a viscoelastic polymeric shell and a volatile gas core, which, within structural confinement, create micro-clusters via inverse jamming and topographical close-packing. Upon heating, microbombs anchored in rigid confinement underwent balloon-like blowing up, allowing for dense clusters via soft interplay between viscoelastic shells. Importantly, the confinement is unyielding against the internal pressure of the microbombs, thereby enabling self-assembled clusters, which can be coupled with topographic inscription to introduce structural hierarchy on the clusters. Our strategy provides densely packed yet ultralight clusters with a variety of complex shapes, cleavages, curvatures, and hierarchy. In turn, these clusters will enrich our ability to explore the assemblies of the ever-increasing range of microparticle systems.Self-assembled systems are normally composed of incompressible building blocks, which constrain their space filling efficiency. Yu et al. show programmable, densely packed clusters using thermally expandable soft microparticles, whereby the self-assembling process is realized via a jamming transition.
The control of game form recognition in experiments: Understanding dominant strategy failures in a simple two person "guessing" game (2007)

The paper focuses on instructions and procedures as the reasons that subjects fail to behave according to the predictions of game theory as observed in two person guessing game experiments. In this game, each of two people has to choose simultaneously a number between 0 and 100. The winner is the person whose chosen number is the closest to 2/3 of the average of the two numbers. The weakly dominant strategy is zero. Because of the simplicity of the game (once it is understood), the widespread failure of subjects to choose the weakly dominant strategy has been interpreted as evidence of some fundamental inability to behave strategically. The experiments reported here demonstrate that the failure to act strategically is related to how the game is presented. Several different presentations are studied. Some subjects fail to recognize the game form when it is presented abstractly. When the game is transformed into the simple isomorphic game and presented in a familiar context, subjects do choose weakly dominant strategies. Suggestions for better experiment control are given.
FEM simulation of charging effect during SEM metrology (2018)

SEM metrology is widely used in microelectronics to control patterns dimensions after many processes, especially patterning. Process control is achieved by verifying that experimental dimensions match targeted ones. However SEM metrology may give erroneous measurements if strong charging occurs. Charging effect impacts on the SEM image contrast and introduces artefacts. This article intends to report on the modeling of the physical phenomena occurring when the electron gun scans a sample and how charging effect occurs. For this, charge dynamics are modeled by taking into account the drift kinetics and the diffusion of electrons. The corresponding Partial Differential Equation system is solved using FEniCS open software. First, we show that when only top view measurement are modeled, the typical contrast of SEM pictures can not be predicted. Second, cross section views are modeled. This time, the expected contrast behavior is obtained. Finally, a full 3D simulation is presented.
Conductance of individual channels in a carbon nanotube field-effect transistor studied by magnetic force microscopy (2009)

We observed current-induced magnetic fields using magnetic force microscopy (MFM) to investigate the channel properties of carbon nanotube field-effect transistors (CNT-FETs). We first modified the shape of a MFM cantilever to enhance its response to magnetic force and then observed the MFM signals around individual CNT channels. We demonstrated that the MFM observations are quite appropriate for studying the CNT channel properties. We also found differences in the threshold gate bias and transconductance among different CNT channels and in the asymmetric conductance of a single CNT channel.
TWO PHOTON EXCITATION OF THE $D^{1}\Delta - X^{1}\Sigma^{+}$ TRANSITION IN CO (1983)

Based on history, examination, and investigations, recruited cases were primarily treated medically; those who had failed the medical treatment approach had dynamic graciloplasty, which demonstrated excellent results during the 1-7 years follow-up period.
Necessity of inositol (1,4,5)-trisphosphate receptor 1 and μ-calpain in NO-induced osteoclast motility (2007)

In skeletal remodeling, osteoclasts degrade bone, detach and move to new locations. Mechanical stretch and estrogen regulate osteoclast motility via nitric oxide (NO). We have found previously that NO stimulates guanylyl cyclase, activating the cGMP-dependent protein kinase 1 (PKG1), reversibly terminating osteoclast matrix degradation and attachment, and initiating motility. The PKG1 substrate vasodilator-stimulated protein (VASP), a membrane-attachment-related protein found in complexes with the integrin alphavbeta3 in adherent osteoclasts, was also required for motility. Here, we studied downstream mechanisms by which the NO-dependent pathway mediates osteoclast relocation. We found that NO-stimulated motility is dependent on activation of the Ca(2+)-activated proteinase mu-calpain. RNA interference (RNAi) showed that NO-dependent activation of mu-calpain also requires PKG1 and VASP. Inhibition of Src kinases, which are involved in the regulation of adhesion complexes, also abolished NO-stimulated calpain activity. Pharmacological inhibition and RNAi showed that calpain activation in this process is mediated by the inositol (1,4,5)-trisphosphate receptor 1 [Ins(1,4,5)P(3)R1] Ca(2+) channel. We conclude that NO-induced motility in osteoclasts requires regulated Ca(2+) release, which activates mu-calpain. This occurs via the Ins(1,4,5)P(3)R1.
OUP accepted manuscript (2016)

PV isolation and reconnection induced measurable changes on the 16-lead ECG that might be used to improve patient follow-up after ablation.
ChemInform Abstract: A Practical Enantioselective Synthesis of α,α‐Diaryl‐2‐ pyrrolidinemethanol. Preparation and Chemistry of the Corresponding Oxazaborolidines. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Piezoelectric single crystal and magnetostrictive Metglas composites: Linear and nonlinear magnetoelectric coupling (2014)

Both the linear (αV) and nonlinear (αV,n) magnetoelectric coefficients were systemically studied in laminated composites of Metglas and [001]-orientated piezoelectric single crystals of Pb(Mg1/3Nb2/3)O3-PbTiO3 (PMN-PT) and Mn-doped PMN-PT. The coefficients were close in value in both cases at quasistatic mode (i.e., 3.8 V/Oe relative to 3.5 V/Oe) and were enhanced by factors of ×18 (Metglas/PMN-PT) and ×32 (Metglas/Mn-doped PMN-PT) at the electromechanical resonance (EMR). The use of Mn-doped PMN-PT crystals results in a higher gain factor due to a larger mechanical quality factor (i.e., 20.9 relative to 40.6). Accordingly, both types of laminates had similar values of αV,n when modulated at 1 kHz, but Mn-doped PMN-PT ones had a higher value when modulated at the EMR.
Antigen Identification Starting from the Genome: A “Reverse Vaccinology” Approach Applied to MenB (2011)

Most of the vaccines available today, albeit very effective, have been developed using traditional "old-style" methodologies. Technologies developed in recent years have opened up new perspectives in the field of vaccinology and novel strategies are now being used to design improved or new vaccines against infections for which preventive measures do not exist. The Reverse Vaccinology (RV) approach is one of the most powerful examples of biotechnology applied to the field of vaccinology for identifying new protein-based vaccines. RV combines the availability of genomic data, the analyzing capabilities of new bioinformatic tools, and the application of high throughput expression and purification systems combined with serological screening assays for a coordinated screening process of the entire genomic repertoire of bacterial, viral, or parasitic pathogens. The application of RV to Neisseria meningitidis serogroup B represents the first success of this novel approach. In this chapter, we describe how this revolutionary approach can be easily applied to any pathogen.
Cryopreservation of Biological Systems–A Confocal Raman Microscopy Study (2010)

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2021 Canadian Urological Association (CUA)-Canadian Uro Oncology Group (CUOG) guideline: Management of castration-resistant prostate cancer (CRPC) (full-text) (2021)

the strength of each recommendation is represented by the words STRONG or WEAK.