MP7-17 DIFFERENTIAL DETECTION OF LESIONS ON MULTI-PARAMETRIC PROSTATE MRI WITH OR WITHOUT USE OF AN ENDORECTAL COIL BASED ON QUANTITATIVE MEASURES OF OBESITY (2014)

You have accessJournal of UrologyImaging/Radiology II1 Apr 2014MP7-17 DIFFERENTIAL DETECTION OF LESIONS ON MULTI-PARAMETRIC PROSTATE MRI WITH OR WITHOUT USE OF AN ENDORECTAL COIL BASED ON QUANTITATIVE MEASURES OF OBESITY Soroush Rais-Bahrami, Murat Elsekkaki, Baris Turkbey, Hong Truong, Harsh Agarwal, Arvin George, M. Minhaj Siddiqui, Marcelino Bernardo, Kinzya Grant, Annerleim Walton-Diaz, Jason Rothwax, Dima Raskolnikov, Nabeel Shakir, Chinonyerem Okoro, Lambros Stamatakis, Maria Merino, Bradford Wood, Peter Choyke, and Peter Pinto Soroush Rais-BahramiSoroush Rais-Bahrami More articles by this author , Murat ElsekkakiMurat Elsekkaki More articles by this author , Baris TurkbeyBaris Turkbey More articles by this author , Hong TruongHong Truong More articles by this author , Harsh AgarwalHarsh Agarwal More articles by this author , Arvin GeorgeArvin George More articles by this author , M. Minhaj SiddiquiM. Minhaj Siddiqui More articles by this author , Marcelino BernardoMarcelino Bernardo More articles by this author , Kinzya GrantKinzya Grant More articles by this author , Annerleim Walton-DiazAnnerleim Walton-Diaz More articles by this author , Jason RothwaxJason Rothwax More articles by this author , Dima RaskolnikovDima Raskolnikov More articles by this author , Nabeel ShakirNabeel Shakir More articles by this author , Chinonyerem OkoroChinonyerem Okoro More articles by this author , Lambros StamatakisLambros Stamatakis More articles by this author , Maria MerinoMaria Merino More articles by this author , Bradford WoodBradford Wood More articles by this author , Peter ChoykePeter Choyke More articles by this author , and Peter PintoPeter Pinto More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.340AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Multiparametric 3T MRI (MP-MRI) with the use of an endorectal coil (ERC) provides improved signal to noise ratio for evaluation of prostatic lesions suspicious for prostate cancer. Herein, we aim to determine the degree of lesion identification lost by eliminating the use of an ERC based upon measures of obesity. METHODS Prospectively collected data on 20 patients on an active surveillance protocol at the National Cancer Institute who have undergone non-ERC MP-MRI in 2013 following a prior ERC MP-MRI were analyzed. MP-MRI prostatic lesions suspicious for prostate cancer were identified and recorded on both ERC and non-ERC studies for each patient. Patient demographics including age, PSA, BMI, abdominal girth, waist circumference, and the drop distance from the anterior abdominal wall to the anterior aspect of the prostate were recorded. Quantitative measures of obesity were measured on T2-weighted MRI sequences. These parameters were analyzed using univariate and multivariable linear regression models individually with age and PSA to assess for significance in the decrease in number of lesions identified on followup studies without ERC use. RESULTS The average number of lesions identified on ERC MP-MRI and followup non-ERC MP-MRI was 1.4±0.9 and 0.5±0.7, respectively. On univariate analysis, age and PSA were not significantly associated with a decrease in the number of lesions identified when the ERC was not used on followup MP-MRI. Of the quantitative parameters of obesity, on univariate analysis, greater BMI (p=0.01) and abdominal girth (p=0.0097) were significantly associated with a larger differential in the number of lesions identified. On multivariable linear regression models incorporating each of the measures of obesity with age and PSA, BMI (p=0.026) and abdominal girth (p=0.019) remained significant independent predictors of the difference in numbers of lesions identified between ERC and non-ERC studies. CONCLUSIONS Typically more intraprostatic lesions are identified by MP-MRI performed with ERC due to the optimized signal to noise ratio. This difference is more dramatic in obese patients where the distance between body and surface coils and the prostate gland are increased. BMI and abdominal girth are predictors of significantly lower lesion identification when ERC is eliminated from the MP-MRI study. Since obesity has a negative impact on the detection of prostate cancer with non-ERC MRI, ERC use may be most important in this patient population. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e73 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Soroush Rais-Bahrami More articles by this author Murat Elsekkaki More articles by this author Baris Turkbey More articles by this author Hong Truong More articles by this author Harsh Agarwal More articles by this author Arvin George More articles by this author M. Minhaj Siddiqui More articles by this author Marcelino Bernardo More articles by this author Kinzya Grant More articles by this author Annerleim Walton-Diaz More articles by this author Jason Rothwax More articles by this author Dima Raskolnikov More articles by this author Nabeel Shakir More articles by this author Chinonyerem Okoro More articles by this author Lambros Stamatakis More articles by this author Maria Merino More articles by this author Bradford Wood More articles by this author Peter Choyke More articles by this author Peter Pinto More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...