gebhart/patrepeval huggingface dataset:
Single Antigen Mismatched Related Donor Allogeneic Stem Transplants Have Similar Outcomes as Matched Unrelated Donor Allogeneic Stem Cell Transplants: A Single Center’s Experience. (2005)

Abstract We retrospectively reviewed transplant outcomes of 32 patients who received an allogeneic stem cell transplant from single human leukocyte antigen (HLA) mismatched related family donors (MMRD), and compared them to 45 case-matched controls who received transplants from matched unrelated donors (MUD). Controls were matched for age, sex, disease type, disease status, CMV seropositivity, and type of conditioning regimen (full versus reduced intensity). Full donor neutrophil engraftment for MMRD and MUD transplants were achieved in 81% and 93% of patients respectively (p=0.1). Grade 2–4 acute graft-versus-host disease (GVHD) developed in 32% of MMRD transplants versus 42% for MUD transplants (p=0.43). Limited and extensive chronic GVHD developed in 22% and 19% of MMRD transplants versus 14% and 30% of MUD transplants (p=0.61). Day 100 transplant related mortality (TRM) for MMRD and MUD transplants were 31% and 33% respectively (p=0.69). Disease relapse occurred in 16% of MMRD transplants versus 13% in MUD transplants (p=0.87). Overall survival at 1 and 3 years for MMRD transplants were 53% and 40% versus 49% and 32% for MUD transplants (p=0.61). There were no statistically significant differences among HLA-A, HLA-B, and HLA-DR MMRD transplants in terms of neutrophil engraftment and grade 2–4 acute GVHD, but day 100 TRM among HLA-DR MMRD transplants were higher than among HLA-A and HLA-B MMRD transplants (50% versus 0% and 17% respectively, p=0.01). Overall survival at 3 years was 53% for HLA-A and HLA-B MMRD transplants, 30% for HLA-DR MMRD transplants, and 32% for MUD transplants (p=0.42). In conclusion, single antigen mismatched related donor allogeneic stem cell transplants have similar transplant outcomes as matched unrelated donor allogeneic stem cell transplants and usually takes a shorter amount of time to stem cell donation. HLA-DR mismatch transplants have higher day 100 TRM than Class I mismatch transplants. Single antigen mismatched related donors should be considered as donors for allogeneic stem cell transplantation. MMRD vs MUD Transplants MMRD MUD P-value MMRD=mismatch related donor; MUD=matched unrelated donor N n=32 n=45 Median age 44 years 41 years P=0.14 High-Risk Disease 63% 71% P=0.51 CMV Seropositivity 45% 42% P=0.93 Full Conditioning 72% 76% P=0.72 Neutrophil Engraftment 81% 93% P=0.1 Grade 2–4 aGVHD 32% 42% P=0.43 Day 100 TRM 31% 33% P=0.69 Disease Relapse 16% 13% P=0.87 3-year OS 40% 32% P=0.6 Figure Figure
Coverage mapping using spatial interpolation with field measurements (2014)

Coverage optimization is a crucial task for a radio network operator. An accurate coverage estimation is a key prerequisite for efficient coverage analysis and optimization. In this paper, we propose a coverage prediction method based on statistical modeling of the wireless environment. We build a Radio Environment Map by interpolating geo-located measurements using the Kriging spatial prediction technique. Moreover, as we perform Kriging on massive observation datasets obtained through field measurement campaigns, we use Fixed Rank Kriging, to reduce the complexity of the Kriging algorithm. We apply the FRK algorithm for Long Term Evolution (LTE) network coverage prediction. We consider as observation data, the coverage measurements obtained by operational drive tests in a rural area. Numerical results show that by using the FRK algorithm, we fulfill a good trade-off between computational complexity and prediction accuracy.
A Theoretical Study of the Mechanism of the Hydride Transfer Reaction between Alkanes and Alkenes Catalyzed by an Acidic Zeolite (1998)

Density functional theory has been used to study the mechanism of the hydride transfer between alkanes and alkenes catalyzed by an acidic zeolite. The (C3H7−H−C3H7)+, (t-C4H9−H−t-C4H9)+, and (C3H7−H−t-C4H9)+ carbonium ion intermediates through which hydride transfer reactions proceed in the gas phase have been localized adsorbed on the catalyst surface, and they have been characterized, like in the gas phase, as reaction intermediates. However, they are about 25 kcal/mol less stable than separated reactants, and consequently, it will be difficult to detect them experimentally. The complete reaction path for the zeolite-catalyzed hydride transfer between propane and propene has been calculated, and it has been found that the (C3H7−H−C3H7)+ carbonium ion intermediate directly decomposes into propane and propene, and not into propane and a covalent alkoxide as previously reported. The activation barrier was calculated assuming this mechanism is in very good agreement with the only available estimation of this value. It has also been shown that the geometries and energies provided by the B3PW91 and B3LYP functionals are equivalent and in very good agreement with the MP2 values and that increasing the basis set size does not significantly alter the results.
Supplementary Figure 2 from PARP-1 Inhibition as a Targeted Strategy to Treat Ewing's Sarcoma (2023)

&lt;p&gt;PDF file - 387K&lt;/p&gt;
Supplementary Data from Enhanced Antitumor Efficacy of a DR5-Specific TRAIL Variant over Recombinant Human TRAIL in a Bioluminescent Ovarian Cancer Xenograft Model (2023)

Supplementary Data from Enhanced Antitumor Efficacy of a DR5-Specific TRAIL Variant over Recombinant Human TRAIL in a Bioluminescent Ovarian Cancer Xenograft Model
Excisive recombination of the SLP1 element in Streptomyces lividans is mediated by Int and enhanced by Xis (1993)

The functions mediating site-specific recombination of the SLP1 element have been mapped to a 2.2-kb region that includes the site of integration (attP), a gene (int) that specifies a function both necessary and sufficient for integration of SLP1, and an open reading frame, orf61, suspected of encoding a protein, Xis, that shows limited similarity to the excisionases of other site-specific recombination systems. Here we describe experiments that investigate the respective roles of orf61 and int in the excision of SLP1. We constructed derivatives of the high-copy-number Streptomyces plasmid pIJ101 that express orf61, int, or both orf61 and int from transcriptional fusions to the Tn5 aph gene and tested the ability of these constructs to promote excision of an adventitious attP-containing plasmid that had been integrated site-specifically into the attB site of the Streptomyces lividans chromosome. Expression of the int gene product alone from an exogenous promoter was sufficient for excision of the integrated plasmid. This result indicates that the SLP1 int-encoded protein can carry out excisive, as well as integrative, recombination. The orf61 gene product, when expressed from an exogenous promoter, inhibited int-mediated integration at the chromosomal attB site. Moreover, under conditions in which excision and transfer normally occur, precise excision of SLP1 was enhanced by the orf61-encoded protein. On the basis of these findings, we here designate the orf61 gene as xis.
Optical Network Models and Their Application to Software-Defined Network Management (2017)

Software-defined networking is finding its way into optical networks. Here, it promises a simplification and unification of network management for optical networks allowing automation of operational tasks despite the highly diverse and vendor-specific commercial systems and the complexity and analog nature of optical transmission. Common abstractions and interfaces are a fundamental component for software-defined optical networking. Currently, a number of models for optical networks are available. They all claim to provide open and vendor agnostic management of optical equipment. In this work, we survey and compare the most important models and propose an intent interface for creating virtual topologies which is integrated in the existing model ecosystem.
Noise in Silicon Nanowires (2006)

The current–voltage and noise characteristics of bridging silicon wires have been measured at room temperature. From the linear current–voltage characteristics the bulk and contact resistance contributions are extracted and modeled. The excess noise observed at low frequencies is interpreted in terms of bulk and contact noise contributions, with the former comparable, in terms of Hooge parameter values, to the low noise levels observed in high-quality silicon devices. The contact noise is significant in some devices and is attributed to the impinging end of the bridging nanowires.
Supplementary Figure 3 from Extracellular Vesicles from High-Grade Glioma Exchange Diverse Pro-oncogenic Signals That Maintain Intratumoral Heterogeneity (2023)

&lt;p&gt;Supplementary Figure 3 related to Figure 3. Presence of P GSC supports pro-oncogenic traits of M GSCs &lt;i&gt;in vivo&lt;/i&gt;&lt;/p&gt;
A quasi-planar approach to the monolithic integration of high-speed VCSEL and resonant photodetector arrays (2003)

Summary form only given. Monolithic arrays of VCSELs and resonant enhanced photodetectors (REPDs) can be integrated into optoelectronic circuits that perform useful functions in optical switching and wavelength division multiplexing (WDM) applications. For these and other optoelectronic interconnect applications, planarity is desirable for monolithic integration, and low power dissipation is required for dense arrays. To minimize power dissipation, oxide-confined VCSELs with small active areas and low operating currents are needed. In the standard (non-planar) technique for fabricating oxide-confined VCSELs, the active area is defined by the lateral wet oxidation of high aluminum content layers from the periphery of an etched mesa, with a typical oxidation length of >10 /spl mu/m. Minimizing the thermal and electrical resistance dictates a large mesa size, at the cost of a longer oxidation time and hence greater uncertainty in the final aperture size. The oxidation time and uncertainty can be reduced without sacrificing planarity or increasing the mesa size by introducing local oxidation centers (e.g., etched holes) from which multiple oxidation fronts can proceed to define an active aperture.
Role ofMycoplasma penetransEndonuclease P40 as a Potential Pathogenic Determinant (1999)

Recently, we reported the purification to homogeneity and characterization of Ca(2+)- and Mg(2+)-dependent endonuclease P40 produced by Mycoplasma penetrans (M. Bendjennat, A. Blanchard, M. Loutfi, L. Montagnier, and E. Bahraoui, J. Bacteriol. 179; 2210-2220, 1997), a mycoplasma which was isolated for the first time from the urine of human immunodeficiency virus-infected patients. To evaluate how this nuclease could interact with host cells, we tested its effect on CEM and Molt-4 lymphocytic cell lines and on peripheral blood mononuclear cells. We observed that 10(-7) to 10(-9) M P40 is able to mediate a cytotoxic effect. We found that 100% of cells were killed after 24 h of incubation with 10(-7) M P40 while only 40% cytotoxicity was obtained after 72 h of incubation with 10(-9) M P40. Phase-contrast microscopy observations of P40-treated cells revealed morphological changes, including pronounced blebbing of the plasma membrane and cytoplasmic shrinkage characteristic of programmed cell death, which is in agreement with the internucleosomal fragmentation of P40-treated cell DNA as shown by agarose gel electrophoresis. We showed that (125)I-radiolabeled or fluorescein isothiocyanate-labeled P40 was able to bind specifically in a dose-dependent manner to the cell membrane of CEM cells, which suggested that the cytotoxicity of P40 endonuclease was mediated by its interaction with the cell surface receptor(s). The concentration of unlabeled P40 required to inhibit by 50% the formation of (125)I-P40-CEM complexes was about 3 x 10(-9) M, indicating a high-affinity interaction. Both P40 interaction and cytotoxicity are Ca(2+) dependent. Our results suggest that the cytotoxicity of M. penetrans observed in vitro is mediated at least partially by secreted P40, which, after interaction with host cells, can induce an apoptosis-like death. These results strongly suggest a major role of mycoplasmal nucleases as potential pathogenic determinants.
Wafer dependence of Johnsen–Rahbek type electrostatic chuck for semiconductor processes (2007)

A Johnsen–Rahbek (J-R type) type electrostatic chuck (ESC) was found to be more sensitive to wafer conditions than classic ESC, including backside dielectric quality and thickness and doping level. The wafer backside dielectric may reduce the clamp force and increase the declamping time, depending on dielectric quality, dielectric thickness, and ESC configurations. These issues and their mechanisms are studied extensively and potential solutions are proposed.
Statistical MIMO Propagation Channel Models - An overview (2004)

Statistical propagation channel models for MIMO systems can be grouped into two classes: physical and analytical. Physical models describe the statistics of the multipath components and are in widespread use for implementation and testing of systems (e.g. 3GPP, IEEE 802.11n). Analytical (or nonphysical) models describe the statistics of the transfer functions between the antenna elements at the transmit and receive side; they are popular for theoretical analysis of MIMO systems. This paper provides a taxonomy of the different modeling approaches, and describes their strengths and weaknesses.
The Campylobacter jejuni MarR-like transcriptional regulators RrpA and RrpB both influence bacterial responses to oxidative and aerobic stresses (2015)

The ability of the human intestinal pathogen Campylobacter jejuni to respond to oxidative stress is central to bacterial survival both in vivo during infection and in the environment. Re-annotation of the C. jejuni NCTC11168 genome revealed the presence of two MarR-type transcriptional regulators Cj1546 and Cj1556, originally annotated as hypothetical proteins, which we have designated RrpA and RrpB (regulator of response to peroxide) respectively. Previously we demonstrated a role for RrpB in both oxidative and aerobic (O2) stress and that RrpB was a DNA binding protein with auto-regulatory activity, typical of MarR-type transcriptional regulators. In this study, we show that RrpA is also a DNA binding protein and that a rrpA mutant in strain 11168H exhibits increased sensitivity to hydrogen peroxide oxidative stress. Mutation of either rrpA or rrpB reduces catalase (KatA) expression. However, a rrpAB double mutant exhibits higher levels of resistance to hydrogen peroxide oxidative stress, with levels of KatA expression similar to the wild-type strain. Mutation of either rrpA or rrpB also results in a reduction in the level of katA expression, but this reduction was not observed in the rrpAB double mutant. Neither the rrpA nor rrpB mutant exhibits any significant difference in sensitivity to either cumene hydroperoxide or menadione oxidative stresses, but both mutants exhibit a reduced ability to survive aerobic (O2) stress, enhanced biofilm formation and reduced virulence in the Galleria mellonella infection model. The rrpAB double mutant exhibits wild-type levels of biofilm formation and wild-type levels of virulence in the G mellonella infection model. Together these data indicate a role for both RrpA and RrpB in the C. jejuni peroxide oxidative and aerobic (O2) stress responses, enhancing bacterial survival in vivo and in the environment.
Opiate Drugs and -Receptor-Mediated Myocardial Protection (1999)

Drugs with delta-opiate activity confer myocardial protection, which is additive to cardioplegia. Use of delta-opiate drugs in this context may have important clinical implications.
Moderation of skeletal muscle reperfusion injury by a sLex-glycosylated complement inhibitory protein (2001)

The role of the sialyl Lewis(x) (sLe(x))-decorated version of soluble complement receptor type 1 (sCR1) in moderating skeletal muscle reperfusion injury, by antagonizing neutrophil endothelial selectin interaction and complement activation, is examined. Mice underwent 2 h of hindlimb ischemia and 3 h of reperfusion. Permeability index (PI) was assessed by extravasation of 125I-labeled albumin. Neutrophil depletion and complement inhibition with sCR1 reduced permeability by 72% (PI 0.81 +/- 0.10) compared with a 42% decrease (PI 1.53 +/- 0.08) observed in neutropenic mice, indicating that part of the complement-mediated injury is neutrophil independent. sCR1sLe(x) treatment reduced PI by 70% (PI 0.86 +/- 0.06), an additional 20% decrease compared with sCR1 treatment (PI 1.32 +/- 0.08). Treatment with sCR1sLe(x) 0.5 and 1 h after reperfusion reduced permeability by 63% (PI 0.09 +/- 0.07) and 52% (PI 1.24 +/- 0.09), respectively, compared with the respective decreases of 41% (PI 1.41 +/- 0.10) and 32% (PI 1.61 +/- 0.07) after sCR1 treatment. Muscle immunohistochemistry stained for sCR1 only on the vascular endothelium of sCR1sLe(x)-treated mice. In conclusion, sCR1sLe(x) is more effective than sCR1 in moderating skeletal muscle reperfusion injury.
Pronociceptive effects of spinal dynorphin promote cannabinoid-induced pain and antinociceptive tolerance (2002)

Recent studies indicate that sustained opioid administration produces increased expression of spinal dynorphin, which promotes enhanced sensitivity to non-noxious and noxious stimuli. Such increased "pain" may manifest behaviorally as a decrease in spinal antinociceptive potency. Here, the possibility of similar mechanisms in the antinociception of spinal cannabinoids was explored. Response thresholds to non-noxious mechanical and noxious thermal stimuli were assessed. Antinociception was determined using the 52 degrees C tail-flick test. Mice received repeated WIN 55,212-2, its inactive enantiomer, WIN 55,212-3 or vehicle (i.th., bid, 5 days). WIN 55,212-2, but not WIN 55,212-3 or vehicle, produced a time-related increased sensitivity to non-noxious and noxious stimuli. WIN 55,212-2, but not WIN 55,212-3 or vehicle, elicited a significant increase in lumbar spinal dynorphin content at treatment day 5. Increased sensitivity to mechanical and thermal stimuli produced by WIN 55,212-2 was reversed to baseline levels by i.th. MK-801 or dynorphin antiserum; control serum had no effect. WIN 55,212-2, but not WIN 55,212-3 or vehicle, produced dose-related antinociception and repeated administration resulted in antinociceptive tolerance. While MK-801 and dynorphin antiserum did not alter acute antinociception produced by WIN 55,212-2, these substances significantly blocked antinociceptive tolerance when given immediately prior to WIN 55,212-2 challenge on day 5. Daily MK-801 pretreatments, prior to WIN 55,212-2 injection, also produced a significant block of antinociceptive tolerance. These data suggest that like opioids, repeated spinal administration of a cannabinoid CB1 agonist elicits abnormal pain, which results in increased expression of spinal dynorphin. Manipulations that block cannabinoid-induced pain also block the behavioral manifestation of cannabinoid tolerance.
Nematic structuring of transparent and multifunctional nanocellulose papers (2017)

The nematic structuring of cellulose nanofibers (CNFs) is proposed as a nanostructural engineering tool for exploiting the potential of CNFs in conceptually new "transparent papers". The nematic-structured CNF papers exhibit superior mechanical properties, optical transparency, gas-barrier properties, heat transfer properties and electrical resistivity, compared with conventional randomly-structured CNF papers.
Internal phase inversion narrow bandwidth MEMS filter (2008)

This paper reports a novel capacitively coupled twin beam resonator internal phase inversion filter fabricated in a SOI MEMS process. A narrow bandwidth of 0.0157% is demonstrated with a low control-voltage of -0.87 V. The bandwidth can be substantially reduced by utilizing an electrical coupling spring as opposed to a mechanical coupling-spring. The bandwidth is tunable with control achieved using a differential DC bias. A summary and comparison with other members of the phase inversion filter family is also included.
Blind Source Separation via Multinode Sparse Representation (2001)

We consider a problem of blind source separation from a set of instan taneous&#13;\nlinear mixtures, where the mixing matrix is unknown. It was discovered recently, that&#13;\nexploiting the sparsity of sources in an appro priate representation according to some signal&#13;\ndictionary, dramatically improves the quality of separation. In this work we use the property&#13;\nof multiscale transforms, such as wavelet or wavelet packets, to decompose signals into sets&#13;\nof local features with various degrees of sparsity. We use this intrinsic property for selecting the best (most sparse) subsets of features for further separation. The performance of the algorithm is verified on noise-free and noisy data. Experiments with simulated signals, musical sounds and images demonstrate significant improvement of separation quality over previously reported results.
Search for low-scale gravity signatures in multi-jet final states with the ATLAS detector at s = 8 $$ \sqrt{s}=8 $$ TeV (2015)

A search for evidence of physics beyond the Standard Model in final states with multiple high-transverse-momentum jets is performed using 20.3 fb -1 of proton-proton collision data at s = 8 TeV recorded by the ATLAS detector at the LHC. No significant excess of events beyond Standard Model expectations is observed, and upper limits on the visible cross sections for non-Standard Model production of multi-jet final states are set. A wide variety of models for black hole and string ball production and decay are considered, and the upper limit on the cross section times acceptance is as low as 0.16 fb at the 95% confidence level. For these models, excluded regions are also given as function of the main model parameters.
Electrochemical Technologies for Water Treatment, Management, and Efficiency (2017)

Reliable access to freshwater is an important issue today and will likely be of even greater importance in the future as the world's population grows and the use of water for human activities and manufacturing, including hydraulic fracking and other mining and industrial processes, increases. There are many critical and interrelated aspects of water treatment, including removal of nitrogen, heavy metals and suspended solids, industrial chemicals, and organic compounds. Several methods for treating freshwater exist, and significant research efforts continue to be expended. However, electrochemical processes may have distinct advantages over other processes, including scalability, point-of-source operational ability, easy of installation and operation, and readiness of integration into renewable energy sources. Electrochemical techniques can address nearly every aspect of water treatment, providing broad applicability. This article outlines recent advances in electrochemical wastewater treatment and provides a perspective on the future outlook of the technology. Multiple electrochemical treatment options are discussed, including removal and recovery of heavy metals, removal of suspended solids and organic compounds, as well as novel applications in the treatment of hydraulic fracking wastewater and nitrogen removal, among others.