gebhart/patrepeval huggingface dataset:
Phase I/II study of T-DM1 alone versus T-DM1 and metronomic temozolomide in secondary prevention of HER2-positive breast cancer brain metastases following stereotactic radiosurgery. (2020)

TPS2572 Background: We demonstrated that low doses of temozolomide (TMZ) administered in a prophylactic, metronomic fashion significantly prevented development of brain metastases in murine models of breast cancer. Based on these findings, we developed a secondary-prevention clinical trial. Methods: Phase I is a standard 3+3 design: T-DM1 3.6mg/kg IV every 21 days plus TMZ 30, 40 or 50 mg/m2 daily, to identify the maximum tolerated dose (MTD) of the combination, and is completing accrual, with 9 patients accrued, currently on the third and last dose level. Phase II will randomize patients to T-DM1 3.6mg/kg versus T-DM1 3.6mg/kg plus TMZ at recommended phase 2 dose (RP2D), to evaluate if addition of TMZ improves the recurrence-free incidence from distant new brain metastases at one year from 50% to 65%. Patients will undergo radiology guided lumbar puncture at baseline and after 6 weeks of treatment (C3D1) for correlative studies, brain MRI, systemic restaging CTs, and questionnaires for evaluation of symptoms and quality of life. Eligibility: HER2+ breast cancer with brain metastases (up to 10 lesions), treated with SRS and/or resection ≤12 weeks before enrollment, no leptomeningeal metastases, no previous WBRT, ECOG ≤2 and adequate organ and marrow function. Biomarkers, including cell free DNA from CSF, serum and tumor block, exosomal DNA, serum markers for neuroinflammation, and patient reported outcomes, will be analyzed in an exploratory fashion. Target accrual: up to 18 patients in phase I and 98 in phase II. Clinical trial information: NCT03190967 .
Tetraarsenic Hexoxide Induces Beclin-1-Induced Autophagic Cell Death as well as Caspase-Dependent Apoptosis in U937 Human Leukemic Cells (2011)

Tetraarsenic hexaoxide (As(4)O(6)) has been used in Korean folk remedy for the treatment of cancer since the late 1980s, and arsenic trioxide (As(2)O(3)) is currently used as a chemotherapeutic agent. However, evidence suggests that As(4)O(6)-induced cell death pathway was different from that of As(2)O(3). Besides, the anticancer effects and mechanisms of As(4)O(6) are not fully understood. Therefore, we investigated the anticancer activities of As(4)O(6) on apoptosis and autophagy in U937 human leukemic cells. The growth of U937 cells was inhibited by As(4)O(6) treatment in a dose- and a time-dependent manner, and IC(50) for As(4)O(6) was less than 2 μM. As(4)O(6) induced caspase-dependent apoptosis and Beclin-1-induced autophagy, both of which were significantly attenuated by Bcl-2 augmentation and N-acetylcysteine (NAC) treatment. This study suggests that As(4)O(6) should induce Beclin-1-induced autophagic cell death as well as caspase-dependent apoptosis and that it might be a promising agent for the treatment of leukemia.
The efficacy of preoperative positron emission tomography-computed tomography (PET-CT) for detection of lymph node metastasis in cervical and endometrial cancer: clinical and pathological factors influencing it (2014)

We studied the diagnostic performance of 18F-fluoro-2-deoxy-d-glucose-positron emission tomography/computed tomography in cervical and endometrial cancers with particular focus on lymph node metastases. Seventy patients with cervical cancer and 53 with endometrial cancer were imaged with 18F-fluoro-2-deoxy-d-glucose-positron emission tomography/computed tomography before lymphadenectomy. We evaluated the diagnostic performance of 18F-fluoro-2-deoxy-d-glucose-positron emission tomography/computed tomography using the final pathological diagnoses as the golden standard. We calculated the sensitivity, specificity, positive predictive value and negative predictive value of 18F-fluoro-2-deoxy-d-glucose-positron emission tomography/computed tomography. In cervical cancer, the results evaluated by cases were 33.3, 92.7, 55.6 and 83.6%, respectively. When evaluated by the area of lymph nodes, the results were 30.6, 98.9, 55.0 and 97.0%, respectively. As for endometrial cancer, the results evaluated by cases were 50.0, 93.9, 40.0 and 95.8%, and by area of lymph nodes, 45.0, 99.4, 64.3 and 98.5%, respectively. The limitation of the efficacy was found out by analyzing it by the region of the lymph node, the size of metastatic node, the historical type of tumor in cervical cancer and the prevalence of lymph node metastasis. The efficacy of positron emission tomography/computed tomography regarding the detection of lymph node metastasis in cervical and endometrial cancer is not established and has limitations associated with the region of the lymph node, the size of metastasis lesion in lymph node and the pathological type of primary tumor. The indication for the imaging and the interpretation of the results requires consideration for each case by the pretest probability based on the information obtained preoperatively.
Depth first generation of long patterns (2000)

Article Depth first generation of long patterns Share on Authors: Ramesh C. Agarwal IBM T. J. Watson Research Center, Yorktown Heights, NY IBM T. J. Watson Research Center, Yorktown Heights, NYView Profile , Charu C. Aggarwal IBM T. J. Watson Research Center, Yorktown Heights, NY IBM T. J. Watson Research Center, Yorktown Heights, NYView Profile , V. V. V. Prasad IBM T. J. Watson Research Center, Yorktown Heights, NY IBM T. J. Watson Research Center, Yorktown Heights, NYView Profile Authors Info & Claims KDD '00: Proceedings of the sixth ACM SIGKDD international conference on Knowledge discovery and data miningAugust 2000 Pages 108–118https://doi.org/10.1145/347090.347114Online:01 August 2000Publication History 197citation1,107DownloadsMetricsTotal Citations197Total Downloads1,107Last 12 Months20Last 6 weeks4 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
AlGaN/GaN Bidirectional Power Switch (2007)

This paper presents a novel approach to achieving BPS functionality using AIGaN/GaN HFETs and for the first time presents experimental data showing the power bidirectional capability of the devices. We present the first detailed study of the bidirectional power switching capability of single and dual gate AIGaN/GaN BPS. One approach to achieve a symmetrical voltage blocking capability in AIGaN/GaN HFET is to place the gate electrode in the middle of the source-drain spacing.
640 Gb/s all-optical logic functions in a PPLN waveguide (2010)

We demonstrate 640 Gb/s all-optical A and B̅, and A̅ and B logic functions using pump depletion in a PPLN waveguide. Bit error rate measurements show the effectiveness of the scheme, with a penalty of <; 2 dB.
Interaction of influenza hemagglutinin amino-terminal peptide with phospholipid vesicles: a fluorescence study (1991)

We have studied tryptophan fluorescence from a 20-residue synthetic peptide corresponding to the amino terminal of the HA2 subunit of the influenza virus hemagglutinin protein, a putative "fusion" peptide. Decay-associated spectra have been obtained at pH 7.4 and at pH 5 (the optimal pH for influenza virus fusion) in the presence and absence of liposomes. We demonstrate that a blue shift in the total steady-state fluorescence spectrum upon binding to liposomes is due to a movement in characteristic emission wavelength and increased lifetime of one of the resolved spectral components. In contrast, a further shift after lowering the pH is the product of a redistribution in the relative amplitudes of spectral components. Also, each decay component is quenched by spin-labels or anthroxyl groups normally located within the hydrocarbon interior of the membranes. Calculations are presented leading to an estimate of the distance of the tryptophan residue from the bilayer center, suggesting that the tryptophan residues are at or near the hydrocarbon-polar interface. No gross positional change was detected between pH values. Rotational depolarization is shown to be retarded by liposome binding, more so at low pH.
Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults (2020)

Interleukin-6 (IL-6) is an inflammatory cytokine that influences the development of inflammatory and aging-related disorders and ultimately longevity. In order to study the influence of variants in genes that regulate inflammatory response on IL-6 levels and longevity, we screened a panel of 477 tag SNPs across 87 candidate genes in >5,000 older participants from the population-based Cardiovascular Health Study (CHS). Baseline plasma IL-6 concentration was first confirmed as a strong predictor of all-cause mortality. Functional alleles of the IL6R and PARP1 genes were significantly associated with 15%-20% higher baseline IL-6 concentration per copy among CHS European-American (EA) participants (all p<10−4). In a case/control analysis nested within this EA cohort, the minor allele of PARP1 rs1805415 was nominally associated with decreased longevity (p=0.001), but there was no evidence of association between IL6R genotype and longevity. The PARP1 rs1805415 – longevity association was subsequently replicated in one of two independent case/control studies. In a pooled analysis of all 3 studies, the “risk” of longevity associated with the minor allele of PARP1 rs1805415 was 0.79 (95%CI 0.62 – 1.02; p=0.07). These findings warrant further study of the potential role of PARP1 genotype in inflammatory and aging-related phenotypes.
Recent developments in multifunctional hybrid nanoparticles opportunities and challenges in cancer therapy (2012)

Multifunctional hybrid nanoparticles combine some of the unique physical and chemical characteristics of two or more classes of materials, such as polymers, liposomes, metals, quantum dots and mesoporous silica among others, to create a versatile and robust new class of nanoparticles. Here we discuss the most recent synthetic strategies to create these hybrid systems and analyze four key design aspects: stability, encapsulation of therapeutic and imaging agents, controlled release of encapsulated agents, and biocompatibility. Through the combination of multiple nanomaterials, hybrid nanoparticles aim to expand the functionality of single-component systems, using the strengths of one material to improve on weaknesses of another. We then examine how hybrid nanoparticle platforms provide unique opportunities in cancer therapy, specifically in the treatment of multidrug resistant cancer. Finally, we discuss some of the challenges hybrid nanoparticles systems might face in their large scale synthesis and commercialization in the biopharmaceutical industry.
Vehicle Lateral Control on Automated Highways: A Backstepping Approach (1997)

Abstract A backstepping controller is designed for lateral guidance of the passenger car in automated highway systems. In this design, the vehicle lateral tracking error is viewed as the output regulated by the relative yaw angle of the car with respect to the road centerline, and the relative yaw angle is controlled by the vehicle’s front wheel steering angle. The closed loop performance of lateral and yaw dynamics can be specified and guaranteed simultaneously in this approach. A smooth road model is used in calculating the feedforward part of the steering command. Nonlinear position feedback, which acts as low gain control at small tracking errors and high gain control at larger tracking errors, is introduced to compromise between passenger ride comfort and tracking accuracy. Simulation results conducted on the complex vehicle model show the effectiveness of the backstepping design approach.
Large frequency tuning of Lithium Niobate laterally vibrating MEMS resonators via electric boundary reconfiguration (2013)

The paper presents a method for tuning the center frequency of Lithium Niobate (LN) laterally vibrating MEMS resonators (LVRs). This technique can be used to address the need for low-cost and miniature frequency-agile components of future programmable RF front-ends. The resonator center frequency is modified by changing the electrical boundary conditions imposed by the excitation electrodes. The underlying theory for the tuning mechanism is discussed and verified by experiments. The experimentally shown tuning range is 3%, which surpasses any demonstration of tuning for MEMS resonators. The predicted tuning range can be as high as 7%.
Tearing and reliability of photovoltaic module backsheets (2019)

Abstract The backsheet in photovoltaic modules belongs to an important class of layered materials where the tearing behavior of the individual layers does not necessarily represent the tearing behavior of the entire backsheet. Such characteristic arises from the interaction between the individual layers during the tearing process, where one layer of the backsheet is mechanically constrained by its neighboring layers and the layers may debond from each other. The mechanical constraint and debonding change the amount of energy dissipated during tearing and affect the overall tearing energy. In this work, we exposed a wide selection of backsheets with polymers including ethylene‐vinyl acetate (EVA), polyethylene terephthalate (PET), polyvinylidene fluoride (PVDF), and ethylene tetrafluoroethylene (ETFE) to damp heat (85°C/85%RH) for up to 2000 hours. We report on the effect of damp heat on the tearing energy as a function of damp heat exposure. We developed a model that describes the tearing energy of a layered structure by accounting for the tearing of the individual layers in the backsheet, the effect of mechanical constraint, and the adhesive debonding between the layers. Additionally, we explore the relationship between the microstructural change in the polymers which resulted from the damp heat exposure and the mechanical properties using modulated differential scanning calorimetry (MDSC), small and wide angle X‐ray scattering (SAXS and WAXS), and tensile testing.
KRT-232 and navitoclax enhance trametinib's anti-Cancer activity in non-small cell lung cancer patient-derived xenografts with KRAS mutations. (2020)

Activating mutations of the KRAS gene are one of the major genomic alterations associated with tumorigenesis of non-small cell lung cancer (NSCLC). Thus far, treatment of KRAS-mutant NSCLC remains an unmet medical need. We determined the <i>in vivo</i> treatment responses of 13 KRAS mutant and 14 KRAS wild type NSCLC patient-derived xenografts (PDXs) to agents that target known NSCLC vulnerabilities: the MEK inhibitor trametinib, the MDM2 inhibitor KRT-232, and the BCL-X<sub>L</sub>/BCL-2 inhibitor navitoclax. The results showed that the tumor regression rate after single agent therapy with KRT-232, trametinib and navitoclax was 11%, 10% and 0%, respectively. Combination therapies of trametinib plus KRT-232 and trametinib plus navitoclax led to improved partial response rates over single-agent activity in a subset of PDX models. Tumor regression was observed in 23% and 50% of PDXs after treatment with trametinib plus KRT-232 and trametinib plus navitoclax, respectively. The disease control rates in KRAS-mutant PDXs tested were 90%-100% after treatment with trametinib plus KRT-232 or plus navitoclax. A correlation analysis of treatment responses and genomic and proteomic biomarkers revealed that sensitivity to KRT-232 was significantly associated with TP53 wild-type or STK11 mutant genotypes (P<0.05). The levels of several proteins, including GSK3b, Nrf2, LKB1/pS334, and SMYD3, were significantly associated with sensitivity to trametinib plus navitoclax. Thus, the combination of trametinib plus KRT-232 or navitoclax resulted in improved efficacy compared with the agents alone in a subgroup of NSCLC PDX model with KRAS mutations. Expanded clinical trials of these targeted drug combinations in NSCLC are warranted.
<em>Agrobacterium</em>-Mediated Immature Embryo Transformation of Recalcitrant Maize Inbred Lines Using Morphogenic Genes (2020)

Demonstrated here is a detailed protocol for Agrobacterium-mediated genetic transformation of maize inbred lines using morphogenic genes Baby boom (Bbm) and Wuschel2 (Wus2). Bbm is regulated by the maize phospholipid transferase gene (Pltp) promoter, and Wus2 is under the control of a maize auxin-inducible (Axig1) promoter. An Agrobacterium strain carrying these morphogenic genes on transfer DNA (T-DNA) and extra copies of Agrobacterium virulence (vir) genes are used to infect maize immature embryo explants. Somatic embryos form on the scutella of infected embryos and can be selected by herbicide resistance and germinated into plants. A heat-activated cre/loxP recombination system built into the DNA construct allows for removal of morphogenic genes from the maize genome during an early stage of the transformation process. Transformation frequencies of approximately 14%, 4%, and 4% (numbers of independent transgenic events per 100 infected embryos) can be achieved for W22, B73, and Mo17, respectively, using this protocol.
The Effect of Relaxin Treatment on Skeletal Muscle Injuries (2005)

These findings may facilitate the development of techniques to eliminate fibrosis, enhance muscle regeneration, and improve functional recovery after muscle injuries.
Advanced digital waveforms for low-Earth-orbit (LEO) FSO links (2020)

For low-Earth-orbit (LEO) satellite communication networks, free space optical (FSO) communication offers high data capacity and security without the spectrum limitations of more conventional RF approaches. However, receive signal power in FSO-LEO links can be highly variable based on multiple dynamic loss mechanisms occurring at different time scales. As a LEO pass moves from higher to lower elevation angles, propagation and scattering losses can vary by more than 10dB over a timescale of minutes. Separately, signal fading caused by atmospheric turbulence can also contribute greater than 10dB variation except at a much faster timescale on the order of milliseconds. Rather than implementing a modulation scheme based on the worst case link margin for a given FSO-LEO link, here we consider intensity modulated, direct detection (IM/DD) digital waveforms that can be dynamically adapted to the changing link conditions to provide increased bandwidth efficiency. In this work, we describe the development of IM/DD waveform modems and a waveform characterization test-bed which incorporates a scintillation playback system. BPSK, QPSK, 8PSK, and 16- QAM waveform performance will be presented under varying scintillation profiles.
Propagation properties of PD-induced electromagnetic wave through L-shaped structure in model GIS measured with UHF sensors (2008)

The authors have studied insulation diagnostic technique of gas-insulated switchgear (GIS) by UHF method. It is known that PD-induced electromagnetic wave is affected by a discontinuity part of impedance such as L-shaped structure, spacers and so on. In this paper, we experimentally investigated influence of L-shaped structure on propagation properties of PDinduced electromagnetic wave measured with UHF sensors in a 66 kV model GIS. Focusing on reflecting properties of TE mode at the L-shaped structure, we discussed the effects of the L-shaped structure on the peak to peak amplitude V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pp</inf> of propagating electromagnetic wave by comparing the experimental results obtained under straight type GIS. As a result, it was found that TE mode component could be reflected at the L-shaped branch, which can result in increasing V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pp</inf> due to the superimpose of the reflected TE mode to TEM mode component depending on the distance between sensor position and L-shaped branch.
Screen Printed Graphene Oxide Textile Biosensor for Applications in Inexpensive and Wearable Point-of-Exposure Detection of Influenza for At-Risk Populations (2018)

A textile screen-printed biosensor was developed using silver conductive electrodes and graphene oxide transduction film built upon both nanoporous polyamide and consumer utility textiles for the detection of environmental exposure to influenza A virus. An affinity assay was constructed upon the graphene oxide layer to introduce influenza protein-specific antibodies to the sensor surface. Validation of fabrication reproducibility and stability, as well as affinity assay stability, was conducted using electrochemical impedance spectroscopy. The textile sensor was utilized for the detection of influenza A in biofluid analog buffer. Its linear dynamic range was from 10 ng/mL to 10 μg/mL with a limit of detection of 10 ng/mL, spanning both pre- and post-symptomatic ranges. The sensor can be integrated into common textiles and worn by at-risk populations to detect exposure to the virus before symptoms manifest. If integrated with Internet-of-Things reporting platforms, this sensor could have the ability to predict potential influenza outbreaks before broad symptoms manifest, reducing the physical and economic burden of the disease.
Adaptive network access mechanism for multi-interfaced terminal over heterogeneous wireless networks (2008)

This paper proposes adaptive network access mechanism to support multi-interfaced terminal over heterogeneous wireless networks. Mobile devices equipped with multi mode interfaces perform an access request based on information of available access networks with cost function. The proposed cost function adopts the minimum required bandwidth and signal to interference plus noise ratio (SINR). In order to evaluate the performance, we compare the proposed algorithm against traditional algorithms. Simulation results show that the proposed algorithm improves the blocking probability and throughput.
Nitroalkene reduction in deep eutectic solvents promoted by BH3NH3 (2021)

Deep eutectic solvents (DESs) have gained attention as green and safe as well as economically and environmentally sustainable alternative to the traditional organic solvents. Here, we report the combination of an atom-economic, very convenient and inexpensive reagent, such as BH<sub>3</sub>NH<sub>3</sub>, with bio-based eutectic mixtures as biorenewable solvents in the synthesis of nitroalkanes, valuable precursors of amines. A variety of nitrostyrenes and alkyl-substituted nitroalkenes, including α- and β-substituted nitroolefins, were chemoselectively reduced to the nitroalkanes, with an atom economy-oriented, simple and convenient experimental procedure. A reliable and easily reproducible protocol to isolate the product without the use of any organic solvent was established, and the recyclability of the DES mixture was successfully investigated.
The Battle for Privacy In Your Pocket [Notes from the Editor] (2016)

Presents the introductory editorial for this issue of the publication.