gebhart/patrepeval huggingface dataset:
Development and Validation of a Novel All-Inclusive LC–MS-MS Designer Drug Method (2018)

Designer drugs including synthetic cannabinoids and synthetic cathinones are an increasing problem due to the ease of access to these compounds. They present analytical challenges inasmuch as the compound structures are numerous and growing within each class. Typically each class of designer compounds is analyzed separately due to differences in chemistry, desired cut-offs or other reasons. Physicians treating "high-risk" patients typically order tests for all "illicit" substances which can span several test classes. Despite that multiple classes of designer drugs are ordered together, there has not been a comprehensive confirmatory test developed to date. Presented here is a novel comprehensive designer drug LC-MS-MS method that combines synthetic cannabinoids and synthetic cathinones, etizolam, a designer benzodiazepine and mitragynine (kratom), a natural product analgesic. This method improves laboratory throughput with a cycle time of ~4.5 min which affords resolution of crucial isomers, such as ethylone and butylone. Development of this method also provided an opportunity to update the list of compounds within the method. Analytes with fewer than five positive specimens in a year of testing with previous separate methods were removed as old and not current. New analytes were added based on reports from NMS Laboratories and the US Drug Enforcement Administration testing and drug seizures, which included etizolam, its major metabolite α-hydroxyetizolam as well as newer synthetic cannabinoids (5-fluoro ADB metabolite 7, AB-FUBINACA metabolite 3, AB-FUBINACA metabolite 4 and MDMB-FUBINACA metabolite M1) and synthetic cathinones (N-ethyl pentylone). Finally, the impact of the new analytes and cut-off changes are discussed in context with patient results from the first 4 months of testing after implementation of the method in the lab.
Peroxynitrite Upregulates Angiogenic Factors VEGF-A, BFGF, and HIF-1α in Human Corneal Limbal Epithelial Cells (2014)

Exposure to elevated extracellular concentrations of ONOO(-) results in upregulation of angiogenic factors in HCLE cells. It is possible that, in the setting of inflammation or infection, that exposure to ONOO(-) could be one contributor to the complex initiators of corneal NV. Validation in vivo would identify an additional potential control point for corneal NV.
RDS – current treatment: State of the art (2012)

Respiratory distress syndrome (RDS) was a disease that was often fatal for newborns well into the 70ies and 80ies. Introduction of oxygen supplementation, mechanical ventilation and CPAP were first attempts to decrease mortality. Lung maturation with prenatal corticosteroids given to the mother turned out to be most important for prevention of RDS.
4: Panel Discussion ??? Reconstructive Challenges in the Radiated Breast (2006)

Carlson, Grant W. MD; Bucky, Louis P. MD; Fine, Neil A. MD; Jones, Glyn Evan MD; Kronowitz, Steven J. MD Author Information
Model-based Deep Learning Receiver Design for Rate-Splitting Multiple Access (2022)

Effective and adaptive interference management is required in next generation wireless communication systems. To address this challenge, Rate-Splitting Multiple Access (RSMA), relying on multi-antenna rate-splitting (RS) at the transmitter and successive interference cancellation (SIC) at the receivers, has been intensively studied in recent years, albeit mostly under the assumption of perfect Channel State Information at the Receiver (CSIR) and ideal capacity-achieving modulation and coding schemes. To assess its practical performance, benefits, and limits under more realistic conditions, this work proposes a novel design for a practical RSMA receiver based on model-based deep learning (MBDL) methods, which aims to unite the simple structure of the conventional SIC receiver and the robustness and model agnosticism of deep learning techniques. The MBDL receiver is evaluated in terms of uncoded Symbol Error Rate (SER), throughput performance through Link-Level Simulations (LLS), and average training overhead. Also, a comparison with the SIC receiver, with perfect and imperfect CSIR, is given. Results reveal that the MBDL receiver outperforms by a significant margin the SIC receiver with imperfect CSIR, due to its ability to generate on demand non-linear symbol detection boundaries in a pure data-driven manner.
Preliminary Trial: Motility Comparisons of a Unique Freezing Technology (UFT) to Liquid Nitrogen Mist Methodology for Cryopreservation of Porcine Spermatozoa (2004)

The motility outcomes of boar semen frozen with newly developed freezing techniques using a new unique freezing technology (UFT) compared with traditional liquid nitrogen methodology were investigated with the intent of improving current fertility outcomes using semen. The UFT is an electronically controlled cooling chamber that houses an organic fluid bath that can be maintained at temperatures below 0 degrees C without solidifying to freeze samples. Four ejaculates from four different boars were collected for this trial. Samples were handled consistently during the pre- and post-freeze processing. From each ejaculate, samples were separated into eight cryopreservation treatment groups, six UFT variations and two control liquid nitrogen groups, immediately before freezing, in replicates of two. After the initial cryopreservation was complete, all samples were stored in liquid nitrogen for at least 48 h. Post-thaw motilities and original motility return percentages were assessed on a random, individual-sample basis. After the initial evaluations, samples from two boars were recollected and frozen using the UFT for breeding purposes. Four sows were bred with the UFT frozen semen to confirm fertility capability. When assessing the individual UFT techniques, all of six UFT techniques had improved post-thaw motilities. However, treatments F (micro = 29%, return micro = 37%) and J (micro = 27%, return micro = 34%) showed the highest statistical improvement for post-thaw (p < 0.05) and original motility percent returns (p < 0.05) when compared with either the control cryo-tube (micro = 15%, return micro = 19%) or straw groups (micro = 12%, return micro = 16%). The UFT semen had a 50% conception rate, with an average of seven piglets from the sows that farrowed. Our preliminary data suggest a higher motility return with a slower pre-freeze phase below the freezing point before the acceleration to liquid nitrogen temperatures. The preliminary data suggest that the UFT could be utilized as a potential cryopreservation option for boar semen.
Data from The Polycomb Gene Product BMI1 Contributes to the Maintenance of Tumor-Initiating Side Population Cells in Hepatocellular Carcinoma (2023)

&lt;div&gt;Abstract&lt;p&gt;Side population (SP) cell analysis and sorting have been successfully applied to hepatocellular carcinoma (HCC) cell lines to identify a minor cell population with cancer stem cell properties. However, the molecular mechanisms operating in SP cells remain unclear. The polycomb gene product BMI1 plays a central role in the self-renewal of somatic stem cells in a variety of tissues and organs and seems to be implicated in tumor development. In this study, we determined the critical role of BMI1 in the maintenance of cancer stem cells with the SP phenotype in HCC cell lines. BMI1 was preferentially expressed in SP cells in Huh7 and PLC/PRF/5 HCC cells compared with the corresponding non-SP cells. Lentiviral knockdown of &lt;i&gt;BMI1&lt;/i&gt; considerably decreased the number of SP cells in both Huh7 and PLC/PRF/5 cells. Long-term culture of purified SP cells resulted in a drastic reduction in the SP subpopulation upon the &lt;i&gt;BMI1&lt;/i&gt; knockdown, indicating that BMI1 is required for the self-renewal of SP cells in culture. More importantly, the &lt;i&gt;BMI1&lt;/i&gt; knockdown abolished the tumor-initiating ability of SP cells in nonobese diabetic/severe combined immunodeficiency mice. Derepression of the &lt;i&gt;INK4A&lt;/i&gt; and &lt;i&gt;ARF&lt;/i&gt; genes that are major targets for BMI1 was not necessarily associated with impaired self-renewal of SP cells caused by &lt;i&gt;BMI1&lt;/i&gt; knockdown. In conclusion, our findings define an important role for BMI1 in the maintenance of tumor-initiating SP cells in HCC. BMI1 might be a novel therapeutic target for the eradication of cancer stem cells in HCC. [Cancer Res 2008;68(19):7742–9]&lt;/p&gt;&lt;/div&gt;
Real-Time Quality Assessment of Long-Term ECG Signals Recorded by Wearables in Free-Living Conditions (2020)

The field of long-term ECG signals self-monitoring by wearable devices is swiftly developing. The analysis of massive amount of collected data is time consuming. It is advantageous to characterize data quality in advance and thereby limit consequent analysis to useable signals.
Genomic analysis of cultivated infant microbiomes identifies Bifidobacterium 2’-fucosyllactose utilization can be facilitated by co-existing species (2023)

Abstract Human milk oligosaccharides (HMOs) ensure proper infant gut microbiome establishment. Isolate studies have revealed the genetic basis for HMO metabolism, but they exclude the possibility of HMO assimilation via synergistic interactions involving multiple organisms. Here, we investigated microbiome responses to 2'-fucosyllactose (2’FL), a prevalent HMO and infant formula additive, by establishing individualized microbiomes using fecal samples from three different infants as the inocula. Bifidobacterium breve , a prominent member of infant microbiomes, typically cannot metabolize 2’FL. Using metagenomic data, we predicted that extracellular fucosidases encoded by co-existing members such as Ruminococcus gnavus initiate 2’FL breakdown, thus critical for B. breve’s growth. Using both targeted co-cultures and by supplementation of R. gnavus into one microbiome, we show that R. gnavus can promote extensive growth of B. breve through the release of lactose from 2’FL. Overall, microbiome cultivation combined with genome-resolved metagenomics demonstrated that HMO utilization can vary with an individual’s microbiome.
Security screening via computational imaging using frequency-diverse metasurface apertures (2017)

Computational imaging is a proven strategy for obtaining high-quality images with fast acquisition rates and simpler hardware. Metasurfaces provide exquisite control over electromagnetic fields, enabling the radiated field to be molded into unique patterns. The fusion of these two concepts can bring about revolutionary advances in the design of imaging systems for security screening. In the context of computational imaging, each field pattern serves as a single measurement of a scene; imaging a scene can then be interpreted as estimating the reflectivity distribution of a target from a set of measurements. As with any computational imaging system, the key challenge is to arrive at a minimal set of measurements from which a diffraction-limited image can be resolved. Here, we show that the information content of a frequency-diverse metasurface aperture can be maximized by design, and used to construct a complete millimeter-wave imaging system spanning a 2 m by 2 m area, consisting of 96 metasurfaces, capable of producing diffraction-limited images of human-scale targets. The metasurfacebased frequency-diverse system presented in this work represents an inexpensive, but tremendously flexible alternative to traditional hardware paradigms, offering the possibility of low-cost, real-time, and ubiquitous screening platforms.
Interactive Portrait Harmonization (2022)

Current image harmonization methods consider the entire background as the guidance for harmonization. However, this may limit the capability for user to choose any specific object/person in the background to guide the harmonization. To enable flexible interaction between user and harmonization, we introduce interactive harmonization, a new setting where the harmonization is performed with respect to a selected \emph{region} in the reference image instead of the entire background. A new flexible framework that allows users to pick certain regions of the background image and use it to guide the harmonization is proposed. Inspired by professional portrait harmonization users, we also introduce a new luminance matching loss to optimally match the color/luminance conditions between the composite foreground and select reference region. This framework provides more control to the image harmonization pipeline achieving visually pleasing portrait edits. Furthermore, we also introduce a new dataset carefully curated for validating portrait harmonization. Extensive experiments on both synthetic and real-world datasets show that the proposed approach is efficient and robust compared to previous harmonization baselines, especially for portraits. Project Webpage at \href{https://jeya-maria-jose.github.io/IPH-web/}{https://jeya-maria-jose.github.io/IPH-web/}
Session 9 overview: Wireless transceiver techniques: Wireless subcommittee (2012)

Lists the sessions held at the conference proceedings.
Chapter 12 Dissolution of Stabilized Amorphous Drug Formulations (2017)

The development of the reciprocating cylinder apparatus arose froma need for an alternative drug release apparatus capable of providingpharmacokinetic and mechanical conditions that more closelyrepresented the various regions throughout the gastrointestinaltract. While the traditional paddle and basket apparatus oﬀered aconvenient means to evaluate most oral drug formulations at singleandmultiple pHs and over long periods, it was diﬃcult to change pHduring the test and changes in agitation rates during the in vitro testare seldom noted as well.
Cost-effective cleaning and high-quality thin gate oxides (1999)

Some recent findings in the area of wafer cleaning and thin oxide properties are presented in this paper. Results are shown for a practical implementation of a simplified cleaning concept that combines excellent performance in terms of metal and particle removal with low chemical and DI-water consumption. The effect of organic contamination on ultrathin gate-oxide integrity is illustrated, and the feasibility of using ozonated DI water as an organic removal step is discussed. Metal outplating from HF and HF/HCl solutions is investigated. Also, the final rinsing step is critically evaluated. It is demonstrated that Si surface roughness without the presence of metal contaminants does not degrade gate-oxide integrity. Finally, some critical remarks on the reliability measurements for ultrathin gate oxides are given; it is shown that erroneous conclusions can be drawn from constant-current charge-to-breakdown measurements.
The Design of Broadband and Efficient Acoustic Wave Transducers (1980)

The basic design criteria for SAW transducers is typically a flat frequency response. design criteria for bulk wave t.ransducers in nondestructive evaluation and medical imaging is the compactness of the impulse response. This criteria is different from the usual flat frequency response criteria because a flat bandwidth does not necessarily imply a compact impulse response. Aniterative optimization program, based on a least mean square algorithm, has been developed and used to simultaneously optimize matching metworks and acoustic parameters to achieve either of the above design criteria. The optimization is first illustrated in t he frequency domain for an IDT transducer. Then the optimization is done in the time domain for a bulk wave transducer with the criterionof reducing the length of the impulse response. The impulse response is thus reduced from about 15 cycles to 3 cycles and has an almost Gaussian frequency response. The increase in t he round trip insertion loss of the transducer due to the tuning is of the order of a few dB. Transducers have been constructed at 5 and 35 Wz (Z = 3 kg/n?-sec) and no front matching layer. The agreement between theory and experiment is excellent. The basic
ChemInform Abstract: Synthesis of α‐(Halomethyl)cycloalkanones. (1990)

Abstract The ketones (I) and (XIII) are silylated to give the enolates (III) and (XIV).
BiDiFuse: a FIJI plugin for fusing bi-directionally recorded microscopic image volumes (2016)

The method is freely available as a plugin for FIJI from https://github.com/JanDetrez/BiDiFuse/ CONTACT: winnok.devos@uantwerpen.be.
Influence of aluminum speciation on the stability of aluminosilicate glasses against crystallization (2012)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Qiuju Zheng, Morten M. Smedskjaer, Randall E. Youngman, Marcel Potuzak, John C. Mauro, Yuanzheng Yue; Influence of aluminum speciation on the stability of aluminosilicate glasses against crystallization. Appl. Phys. Lett. 23 July 2012; 101 (4): 041906. https://doi.org/10.1063/1.4739005 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioApplied Physics Letters Search Advanced Search |Citation Search
3D laser micromachining, microthrusters and nanosatellites (2003)

Summary form only given, as follows. Both European and US space agencies are evaluating the use of miniature, but fully capable, satellites for specific scientific, Earth observation and communication missions. The concepts currently under study are satellites with total mass between 1-20 Kg. In 1993, The Aerospace Corporation presented a viable concept for a 1 Kg class satellite (i.e. the nano-satellite or silicon-satellite) that is designed to be mass producible using advanced fabrication techniques, microelectromechanical systems (MEMS) and advanced packaging technology. Most of the nanosatellite subsystems can be fabricated using the planar (e.g. 2D) microelectronics or the extruded 2D (e.g. also called 2.5 D) silicon MEMS processing techniques. However, for the micropropulsion subsystem the fluid flow dynamics dictates the need for true 3D material processing (e.g. an hourglass shape nozzle) to make efficient use of the limited onboard propellant. Laser material processing is being used for the rapid prototype fabrication of various micropropulsion designs. For the semiconductor materials, a CW and pulsed laser direct write tool is being used for patterning, micromachining and metalization. In addition, for this application two laser direct-write techniques are being developed-a volumetric exposure technique for the "micro-machining" of photosensitive glass/ceramic material and a non thermal surface texturing technique for enhancing surface chemical activity. The nanosatellite concept is presented in overview while the laser techniques are described in detail.
MicroRNAs act as decoy molecules to restore granulocytic maturation of differentiation-arrested BCR/ABL+ myeloid progenitors (2008)

1494 Altered microRNA (miR) expression contributes to aberrant post-transcriptional regulation of gene expression in different type of cancers; however, their role in the pathogenesis and progression of chronic myelogenous leukemia (CML) from chronic phase (CP) to blast crisis (BC) is still largely unknown. Microarray analysis revealed that a discrete number of miRs are significantly upregulated (6.7% of the total 505 miRs present on the chip; 34 miRs) or downregulated (2.8%; 14 miRs) in an imatinib-sensitive manner in CML-BCCD34+ compared to CML-CPCD34+ progenitors and in BCR/ABL+ hematopoietic cell lines compared to untransformed cells. Among them, we investigated miR-223, miR-15a/16-1 and miR-328, a microRNA with no currently known function, because of their importance in myelopoiesis, potential role as tumor suppressors and sequence homology with the 5’ UTR of CEBPA mRNA, respectively. In BCR/ABL cell lines and primary CD34+ patient-derived myeloid cells, Northern blot and/or TaqMan RT-PCR analyses revealed that miR-223, miR-328, miR-15a/16-1 expression was markedly suppressed (50-75% inhibition) in a imatinib-sensitive manner by BCR/ABL kinase activity. Interestingly, sequence analysis of miR-223 and miR-328 revealed homology with the hnRNP E2-binding site contained in the CEBPA uORF/spacer mRNA. Accordingly, REMSA and UV-crosslinking showed that miR-223 and to a greater extent miR-328 bind recombinant and endogenous hnRNP E2 protein and compete for its binding to the CEBPA uORF/spacer region, which is required for hnRNP E2-mediated translational inhibition of CEBPA in CML-BCCD34+ progenitors, suggesting that miR-223 and miR-328 may act as decoy molecules that interfere with hnRNP E2 translation-inhibitory activity. Indeed, ectopic miR-223 expression restored G-CSF-driven C/EBPα-dependent granulocytic maturation of differentiation-arrested 32D-BCR/ABL cells, whereas it did not have any effect on cytokine-independent growth and clonogenic potential. Consistent with its ability to bind hnRNP E2, miR-328 also rescued C/EBPα expression and differentiation of cytokine-independent 32D-BCR/ABL myeloid precursors and primary CD34+ CML-BC progenitors. By contrast, BCR/ABL-dependent colony formation was markedly reduced by miR-15a/16-1 overexpression (65-75% inhibition, P
Experimental Realization of Decoherence-Free Subspace in Neutron Interferometry (2011)

A decoherence-free subspace (DFS) is an important class of quantum-error-correcting (QEC) codes that have been proposed for fault-tolerant quantum computation. The applications of QEC techniques, however, are not limited to quantum-information processing (QIP). Here we demonstrate how QEC codes may be used to improve experimental designs of quantum devices to achieve noise suppression. In particular, neutron interferometry is used as a test bed to show the potential for adding quantum error correction to quantum measurements. We built a five-blade neutron interferometer that incorporates both a standard Mach-Zender configuration and a configuration based on a DFS. Experiments verify that the DFS interferometer is protected against low-frequency mechanical vibrations. We anticipate these improvements will increase the range of applications for matter-wave interferometry.
The synthesis of 3-amino-3-methylbicyclo[3.3.1]nonanes: Endo-selectivity in the Ritter reaction of 1,3,5,7α-tetramethylbicyclo[3.3.1]nonan-3-ol (1999)

1,3,5,7α- and 1,3,5,7β-Tetramethylbicyclo[3.3.1]nonan-3-ols 3a and 3b were prepared from the corresponding ketones 2a and 2b. 7α-Methyl isomer 3a gave selectively endo-3α-N-formylaminobicyclononane 10 in the Ritter reaction with trimethylsilyl cyanide. 7β-Methyl epimer 3b suffered water elimination resulting in bicyclo[3.3.1]non-2-ene 12 under the same reaction conditions. The endo-amide structure was confirmed by X-ray analysis..
Diode-pumped electro-optically Q-switched microchip lasers (1992)

The electro-optically Q-switched microchip laser1,2 used in the experiments described here (illustrated in Figure 1) consists of a 532-μm long piece of Nd:YAG bonded to a 904-μm long piece of LiTaO3. Both materials are polished flat and parallel on the two faces normal to the optic axis. The pump face of the Nd:YAG is dielectrically coated to transmit the pump light and to be highly reflecting at the oscillating wavelength (1064 µm). A partially transmitting mirror between the two materials has a reflectivity of 95% at 1.064 µm and is highly reflecting at the pump wavelength. The opposite face of the LiTaO3, is coated for 50% reflectivity at 1.064 µm. The LiTaO3 is oriented with, its c-axis orthogonal to the cavity axis.
Motion sequence criteria for favorable occupant kinematics in rear impacts (2022)

Rear motion sequence criteria (MSC) define favorable kinematics in rear impacts. MSC complement the assessment of biomechanical responses in sled and crash testing to ensure an overall evaluation of occupant restraint in rear impacts.