gebhart/patrepeval huggingface dataset:
The USC Creative IT Database: A Multimodal Database of Theatrical Improvisation (2010)

All in-text\treferences\tunderlined\tin\tblue\tare\tlinked\tto\tpublications\ton\tResearchGate, letting you\taccess\tand\tread\tthem\timmediately.
Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers (2011)

Two single nucleotide polymorphisms (SNPs) at 6q25.1, near the ESR1 gene, have been implicated in the susceptibility to breast cancer for Asian (rs2046210) and European women (rs9397435). A genome-wide association study in Europeans identified two further breast cancer susceptibility variants: rs11249433 at 1p11.2 and rs999737 in RAD51L1 at 14q24.1. Although previously identified breast cancer susceptibility variants have been shown to be associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers, the involvement of these SNPs to breast cancer susceptibility in mutation carriers is currently unknown. To address this, we genotyped these SNPs in BRCA1 and BRCA2 mutation carriers from 42 studies from the Consortium of Investigators of Modifiers of BRCA1/2. In the analysis of 14 123 BRCA1 and 8053 BRCA2 mutation carriers of European ancestry, the 6q25.1 SNPs (r(2) = 0.14) were independently associated with the risk of breast cancer for BRCA1 mutation carriers [hazard ratio (HR) = 1.17, 95% confidence interval (CI): 1.11-1.23, P-trend = 4.5 × 10(-9) for rs2046210; HR = 1.28, 95% CI: 1.18-1.40, P-trend = 1.3 × 10(-8) for rs9397435], but only rs9397435 was associated with the risk for BRCA2 carriers (HR = 1.14, 95% CI: 1.01-1.28, P-trend = 0.031). SNP rs11249433 (1p11.2) was associated with the risk of breast cancer for BRCA2 mutation carriers (HR = 1.09, 95% CI: 1.02-1.17, P-trend = 0.015), but was not associated with breast cancer risk for BRCA1 mutation carriers (HR = 0.97, 95% CI: 0.92-1.02, P-trend = 0.20). SNP rs999737 (RAD51L1) was not associated with breast cancer risk for either BRCA1 or BRCA2 mutation carriers (P-trend = 0.27 and 0.30, respectively). The identification of SNPs at 6q25.1 associated with breast cancer risk for BRCA1 mutation carriers will lead to a better understanding of the biology of tumour development in these women.
Abstract B10: Overexpression of the lncRNA PVT1 contributes to the cervical cancer phenotype, possibly via association with nucleolin (2016)

Abstract The plasmacytoma variant translocation 1 gene (PVT1) is an lncRNA that has been designated as an oncogene due to its contribution to the phenotype of multiple cancers. Although the mechanism by which PVT1 influences disease processes has been studied in multiple cancer types, its role in cervical tumorigenesis remains unknown. Thus, the present study was designed to investigate the role of PVT1 in cervical cancer in vitro and in vivo. PVT1 expression was measured by quantitative PCR (qPCR) in 121 invasive cervical carcinoma (ICC) samples, 19 normal cervix samples, and a cervical cell line (SiHa). Further, we used targeted knockdown in conjunction with functional assays to examine PVT1's effects on cervical cancer cell proliferation, migration and invasion, apoptosis, and cisplatin resistance. Our results demonstrate that PVT1 expression is significantly increased in ICC tissue versus normal cervix. PVT1 knockdown in cervical cancer cell lines resulted in significantly decreased cell proliferation, migration and invasion. Further, apoptosis and cisplatin cytotoxicity were significantly increased in PVT1 siRNA-transfected cells. Finally, we show that PVT1 associates with Nucleolin protein and may aid in its stabilization of GADD45A mRNA providing a possible mechanism by which PVT1 overexpression drives cervical carcinogenesis. Citation Format: Marissa Iden, Samantha Fye, Keguo Li, Tamjid Chowdhury, Ramani Ramchandran, Janet S. Rader. Overexpression of the lncRNA PVT1 contributes to the cervical cancer phenotype, possibly via association with nucleolin. [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicines ; 2015 Dec 4-7; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2016;76(6 Suppl):Abstract nr B10.
Role-based adaptation for video conferencing in healthcare applications (2014)

A large number of health-related applications are being developed using web infrastructure. Video is increasingly used in healthcare applications to enable communications between patients and care providers. We present a video conferencing system designed for healthcare applications. In face of network congestion, the system uses role-based adaptation to ensure seamless service. A new web technology, WebRTC, is used to enable seamless conferencing applications. We present the video conferencing application and demonstrate the usefulness of role based adaptation.
Intrazeolitic and Rare Gas Isolated Silver Atom and Silver Cluster Spectroscopy, Photoprocesses, and Support Interactions (1983)

Guest-host interactions involving both ground and excited electronic states are shown to play a critical role in determining the energetic properties and dynamical processes of silver atoms and small silver clusters isolated in faujasite-type zeolites and rare gas matrices. An investigation of the spectroscopy and photoprocesses of these immobilized metal reagents indicates that although the ground state metal-support interactions can be classified as weak,the excited state interactions are exceptionally sensitive to the nature of the support. In fact they are of sufficient magnitude to result in a range of novel metal-support relaxation processes including cage-relaxed metal atomic fluorescence/photodiffusion/photoaggregation, metal cluster photofragmentation/cage-relaxed metal atomic fluorescence/cage-recombination and metal cluster photoisomerization. An appreciation of these kinds of interactions is important as they clearly bear a relationship to metal-support effects known to be operative in supported metal catalysts.
Discrete-time signal processing / Alan V. Oppenheim, Ronald W. Shafer (1989)

We present two cases of spontaneous intracerebellar migration of a pseudomeningocele. This is a rarely reported complication of posterior fossa surgery with possible life threatening cerebellar mass effect. The probable mechanism is a slow but progressive cerebrospinal fluid (CSF) movement (one-way valve mechanism) into the pseudomeningocele with secondary herniation or dissection through a weakened dura into the cerebellum causing progressive or acute cerebellar dysfunction. Evacuation and dural repair with or without CSF shunting or marsupialisation results in resolution of the symptoms.
Fuzzy-Based Language Grounding of Geographical References: From Writers to Readers (2019)

We describe an applied methodology to build fuzzy models of geographical expressions, which are meant to be used for natural language generation purposes. Our approach encompasses a language grounding task within the development of an actual datato-text system for the generation of textual descriptions of live weather data. For this, we gathered data from meteorologists through a survey and built consistent fuzzy models that aggregate the interpersonal variations found among the experts. A subset of the models was utilized in an illustrative use case, where we generated linguistic descriptions of weather maps for specific geographical expressions. These were used in a task-based evaluation to determine how well potential readers are able to identify the geographical expressions grounded on the models.
Related Article from The Ultimate in Cancer Chemoprevention: Cancer Vaccines (2023)

Related Article from The Ultimate in Cancer Chemoprevention: Cancer Vaccines
Cross‐border reproductive care (2021)

The most common forms of fertility treatments provided within cross-border reproductive care (CBRC) are assisted reproductive technologies, namely in-vitro fertilization and ICSI, for many indications. The main reasons for CBRC are legal restrictions, high costs and lack of availability of high-quality treatment in home countries. Due to its complex nature and implications worldwide, CBRC has become an emerging dilemma on the global healthcare agenda and yet little is known about its magnitude and scope. There are huge differences in the medical, legal, economic, and cultural conditions leading to CBRC. As an industry, CBRC involves many different parties, including patients, doctors, brokers, as well as donors and surrogates. Sex selection for nonmedical reasons is an ongoing ethical debate in many societies worldwide, including the US. Standardization of data collection and establishment of reliable national and global registries are still needed in order to determine the accurate magnitude and scope of CBRC worldwide.
Resistive Glass IM-TOFMS (2010)

The design of a new ion mobility mass spectrometer (IM-MS) is presented. This new design features an ambient-pressure resistive glass ion mobility drift tube (RGIMS) coupled to a high-resolution time-of-flight mass spectrometer (TOFMS) by an enhanced interface that includes two segmented quadrupoles. The interface design demonstrates an increase in sensitivity while maintaining high resolving power typically achieved for ambient-pressure IMS drift tubes. Performance of the prototype instrument was evaluated and the analytical figures of merit for standard solutions as well as complex samples such as human blood were determined. For a 3 μM solution of caffeine, the peak was collected in 36 s and gave a response of 10 counts/s. The detection limit (defined as 1 count/s) was calculated to be 300 nM concentration of caffeine from the response rate from the 36 s run. Controlled fragmentation of caffeine was achieved through adjustment of voltages applied on the interface lenses. Over 300 tentative metabolites were detected in human blood along with 80 isomers/isobars with ion counts >5. Isotope ratios from extracted mass spectra of selected mobility peaks were used to identify selected metabolite compounds. High separation power for both IMS (resolving power, t(d)/Δt(w1/2), was 85) and MS (mass resolving power, m/Δm, maximum was 7000 with a mass accuracy between 2 and 10 ppm) was measured. Developed software for data acquisition, control and display allowed flexibility in instrument control, data evaluation and visualization.
The anterolateral ligament (2014)

There have been differing descriptions of the anterolateral structures of the knee, and not all have been named or described clearly. The aim of this study was to provide a clear anatomical interpretation of these structures. We dissected 40 fresh-frozen cadaveric knees to view the relevant anatomy and identified a consistent structure in 33 knees (83%); we termed this the anterolateral ligament of the knee. This structure passes antero-distally from an attachment proximal and posterior to the lateral femoral epicondyle to the margin of the lateral tibial plateau, approximately midway between Gerdy's tubercle and the head of the fibula. The ligament is superficial to the lateral (fibular) collateral ligament proximally, from which it is distinct, and separate from the capsule of the knee. In the eight knees in which it was measured, we observed that the ligament was isometric from 0° to 60° of flexion of the knee, then slackened when the knee flexed further to 90° and was lengthened by imposing tibial internal rotation.
LBT-Based Adaptive Channel Access for LTE-U Systems (2016)

Driven by the demand for more radio spectrum resources, mobile operators are looking to exploit the unlicensed spectrum as a complement to the licensed spectrum. LTE-unlicensed (LTE-U), also referred to as licensed-assisted access by the third generation partnership project, is an extension of the LTE standard operating on the unlicensed spectrum. To realize LTE-U, its coexistence with Wi-Fi systems is the main challenge and must be addressed. In this paper, a listen-before-talk access mechanism featuring an adaptive distributed control function protocol is adopted for the small base stations (SBSs), whereby the backoff window size is adaptively adjusted according to the available licensed spectrum bandwidth and the Wi-Fi traffic load to satisfy the quality-of-service requirements of small cell users and minimize the collision probability of Wi-Fi users. Meanwhile, both licensed and unlicensed spectrum bands are jointly allocated to optimize spectrum efficiency. An admission control mechanism is further developed for the SBS to limit collision with Wi-Fi traffic. Extensive simulation results show that the proposed schemes achieve fair and harmonious coexistence between LTE-U small cells and the surrounding Wi-Fi service sets and substantially outperform baseline non-adaptive channel access mechanisms in the unlicensed spectrum.
Blue-light-emitting polymer lasers with non-periodic circular Bragg resonators (2008)

We present single mode optically pumped lasing from a new resonator structure for polymer lasers employing nonperiodic circular Bragg gratings. Our devices, using a polyfluorene derivative (BN-PFO) as gain medium, are the first blue-emitting circular grating semiconductor lasers (either organic or inorganic). They exhibit feature sizes as small as 47 nm and emit azimuthally polarized beams with a spectral linewidth &asymp; 0.2 nm. We find a minimum lasing threshold energy density of 1.2 &mu;J/cm<sup>2</sup> (10 Hz, 8 ns, 355 nm Nd:YAG laser excitation). The quality factor of the resonator modal fields is found to be at least 2200 for these devices.
Formation and Characterization of γ- Al2O3 Films Produced by Oxidation of β–NiAl(110) (2009)

Extended abstract of a paper presented at Microscopy and Microanalysis 2009 in Richmond, Virginia, USA, July 26 – July 30, 2009
Predictive Factors for Proximal Junctional Kyphosis in Long Fusions to the Sacrum in Adult Spinal Deformity (2013)

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Methodology to optimize detector geometry in fluorescence tomography of tissue using the minimized curvature of the summed diffuse sensitivity projections (2013)

The dependence of the sensitivity function in fluorescence tomography on the geometry of the excitation source and detection locations can severely influence an imaging system's ability to recover fluorescent distributions. Here a methodology for choosing imaging configuration based on the uniformity of the sensitivity function is presented. The uniformity of detection sensitivity is correlated with reconstruction accuracy in silico, and reconstructions in a murine head model show that a detector configuration optimized using Nelder-Mead minimization improves recovery over uniformly sampled tomography.
CXC Chemokine Ligand 10 Neutralization Suppresses the Occurrence of Diabetes in Nonobese Diabetic Mice through Enhanced β Cell Proliferation without Affecting Insulitis (2004)

We have shown that neutralization of IFN-inducible protein 10/CXCL10, a chemokine for Th1 cells, breaks Th1 retention in the draining lymph nodes, resulting in exacerbation in Th1-dominant autoimmune disease models induced by immunization with external Ags. However, there have been no studies on the role of CXCL10 neutralization in Th1-dominant disease models induced by constitutive intrinsic self Ags. So, we have examined the effect of CXCL10 neutralization using a type 1 diabetes model initiated by developmentally regulated presentation of beta cell Ags. CXCL10 neutralization suppressed the occurrence of diabetes after administration with cyclophosphamide in NOD mice, although CXCL10 neutralization did not significantly inhibit insulitis and gave no influence on the trafficking of effector T cells into the islets. Because both CXCL10 and CXCR3 were, unexpectedly, coexpressed on insulin-producing cells, CXCL10 was considered to affect mature and premature beta cells in an autocrine and/or paracrine fashion. In fact, CXCL10 neutralization enhanced proliferative response of beta cells and resultantly increased beta cell mass without inhibiting insulitis. Thus, CXCL10 neutralization can be a new therapeutic target for beta cell survival, not only during the early stage of type 1 diabetes, but also after islet transplantation.
Differentiable Programming of Reaction-Diffusion Patterns (2021)

Reaction-Diffusion (RD) systems provide a computational framework that governs many pattern formation processes in nature. Current RD system design practices boil down to trial-and-error parameter search. We propose a differentiable optimization method for learning the RD system parameters to perform example-based texture synthesis on a 2D plane. We do this by representing the RD system as a variant of Neural Cellular Automata and using task-specific differentiable loss functions. RD systems generated by our method exhibit robust, non-trivial 'life-like' behavior.
Kinetics of primer‐dependent polynucleotide phosphorylase synthetic reactions (1968)

Abstract The kinetics of a model for the primer‐dependent, polynucleotide phosphorylase‐catalyzed synthesis of oligo‐ and polynucleotides is developed. Numerical solutions are presented which correspond to a wide variety of possible reaction conditions. The model seems capable of explaining the types of behavior which have been experimentally observed for polynucleotide phosphorylase reactions. The most unusual of these is the presence of a transient intermediate of high molecular weight polynucleotide chains which is subsequently degraded to an equilibrium mixture of short oligonucleotides. Methods of estimating the time of occurrence and maximum size of the polymer are discussed. Analytical solutions are developed for the concentrations of free enzyme and unreacted nucleoside diphosphate. In conjunction with equilibrium data these may permit the rate constants required by the model to be determined.
Formation of undulated lamellar structure from ABC block terpolymer blends with different chain lengths (2010)

The effect of molecular weight distribution of ABC linear terpolymers on the formation of periodic structures was investigated. Three poly(isoprene-b-styrene-b-2-vinylpridine) triblockterpolymers with molecular weights of 26k, 96k, and 150k were blended variously. Three-phase, four-layer lamellar structures were observed when polydispersity index (PDI) was low, but it has been found that simple lamellar structure with flat surface transforms into an undulated lamellar one, where two interfaces, i.e., I/S and S/P, are both undulated, and they are synchronizing each other if PDI exceeds the critical value. This new structure could be formed due to the periodic and "weak" localization of three chains along the domain interfaces, which produces periodic surfaces with nonconstant mean curvatures. With further increase of PDI, the blend macroscopically phase-separated into different microphase-separated structures.
High-Throughput Microrna Profiling in Patients with Waldenstrom’s Macroglobulinemia. (2008)

Abstract Waldenström’s macroglobulinemia (WM) is an incurable B cell malignancy characterized by the accumulation of IgM secreting clonally related bone marrow lymphoplasmacytic cells (LPC) including CD19+ B-cells and CD138+ plasma cells. Despite intense research efforts, the pathogenetic basis for this disease remains to be clarified. MicroRNAs are small noncoding RNAs that regulate the expression of protein-coding genes by inducing translational inhibition and through cleavage of targeted transcripts by partial or complete base pairing. We therefore evaluated the expression of 384 microRNAs in CD19+ and CD138+ sorted bone marrow lymphoplasmacytic from 13 untreated WM patients, and compared their expression profiling to analogous lymphoplasmacytic cells taken from the bone marrows of 13 healthy donors. Data obtained from microRNA arrays was analyzed using SDS, RQ manager, R and dChip softwares. Relative expression was calculated using the comparative Ct method through RQ manager and dChip softwares. Of the 384 microRNAs evaluated in CD19+ patient cells, miR-192, -125b, -21, -155 demonstrated significant upregulation, whereas miR-181c, -572, and -650 were significantly down regulated compared to healthy donor CD19+ bone marrow cells (p&amp;lt;0.05). Analysis of bone marrow derived CD138+ cells from WM patients demonstrated significant upregulation in miR-192, -193b, -17-3p, -585, -148b, whereas miR-29c, -155, -126, -148a, -125a, -181d, -30a-3p, let-7b, let-7c were downregulated in comparison to healthy donor CD138+ bone marrow cells (p&amp;lt;0.05). Importantly, characterization of the modulated microRNAs found in these studies demonstrated a critical role in growth and survival pathways through modulation of several genes including HOX, BCL-2 and c-myc. Taken together, these studies demonstrate significant differences in microRNA expression between comparable WM and healthy donor lymphoplasmacytic cell populations, and identify aberrancies in microRNAs with a pivotal role in the growth and survival of B-cells.
Self-assembled titanium calcium oxide nanopatterns as versatile reactive nanomasks for dry etching lithographic transfer with high selectivity (2012)

We report the simple preparation of ultra-thin self-assembled nanoperforated titanium calcium oxide films and their use as reactive nanomasks for selective dry etching of silicon. This novel reactive nanomask is composed of TiO(2) in which up to 50% of Ti was replaced by Ca (Ca(x)Ti(1-x)O(2-x)). The system was prepared by evaporation induced self-assembly of dip-coated solution of CaCl(2), TiCl(4) and poly(butadiene-block-ethylene oxide) followed by 5 min of thermal treatment at 500 °C in air. The mask exhibits enhanced selectivity by forming a CaF(2) protective layer in the presence of a chemically reactive fluorinated plasma. In particular it is demonstrated that ordered nano-arrays of dense Si pillars, or deep cylindrical wells, with high aspect ratio i.e. lateral dimensions as small as 20 nm and height up to 200 nm, can be formed. Both wells and pillars were formed by tuning the morphology and the homogeneity of the deposited mask. The mask preparation is extremely fast and simple, low-cost and easily scalable. Its combination with reactive ion etching constitutes one of the first examples of what can be achieved when sol-gel chemistry is coupled with top-down technologies. The resulting Si nanopatterns and nanostructures are of high interest for applications in many fields of nanotechnology including electronics and optics. This work extends and diversifies the toolbox of nanofabrication methods.
Photonic subsampling analog-to-digital conversion of microwave signals at 40-GHz with higher than 7-ENOB resolution (2008)

Conversion of analog signals into digital signals is one of the most important functionalities in modern signal processing systems. As the signal frequency increases beyond 10 GHz, the timing jitter from electronic clocks, currently limited at approximately 100 fs, compromises the achievable resolution of analog-to-digital converters (ADCs). Owing to their ultralow timing jitter, the use of optical pulse trains from passively mode-locked lasers has been considered to be a promising way for sampling electronic signals. In this paper, based on sub-10 fs jitter optical sampling pulse trains, we demonstrate a photonic subsampling ADC that downconverts and digitizes a narrowband microwave signal at 40 GHz carrier frequency with higher than 7 effective-number-of-bit (ENOB) resolution.
Design and implementation of spiral-type Marchand Balun using glass-based IPD technology (2008)

In this paper, a spiral-type Marchand balun design in glass-based IPD technology has been presented. The EM simulation results show good agreement with measurements. The balun in this design has excellent return and insertion loss characteristics. In addition, it is also with good amplitude and phase balance and can achieve high CMRR performance. This balun design has been successfully employed in Bluetooth and WLAN system-in-package applications.