gebhart/patrepeval huggingface dataset:
Author Correction: Skin tolerant inactivation of multiresistant pathogens using far-UVC LEDs (2022)

Figure 4. (a) DNA damage for irradiated porcine skin using 254 nm and 233 nm light sources with 40 mJ/cm 2 . Untreated skin served as control. The mean values of the epidermal DNA damage in % are calculated from at least three experiments and the error bars show the standard error of the mean. (b)-(e) Histologic images HE and CPD stained porcine skin after irradiation using the far-UVC LED irradiation system without (c) and with filter (d), in comparison, untreated skin (e) and skin after irradiation with near-UVC radiation at 254 nm (f). Arrows mark CPD positive cells. The scale bar is 100 m.
Adaptive time-domain macromodeling algorithm for fast termination of FDTD simulations (2010)

In this paper, a novel adaptive stopping criterion for FDTD simulations of microwave components is applied to a package example. The new stopping criterion relies on the Vector Fitting algorithm to successively build an updated macromodel for the frequency response of the device under study based on increasing time-limited transient responses. In this way, it aims at minimizing the number of timesteps and, hence, the overall simulation time to capture the device's frequency response within a given frequency band up to a predefined accuracy level.
Parameter Identification using Nonlinear Observer Theory (1990)

This paper presents preliminary results from an investigation into identification of parameters appearing nonlinearly in system dynamics. After presentation of background material on identifiability of such systems, an identifier based on the Extended Luenberger Observer is constructed for a class of nonlinear systems. Conditions sufficient for global convergence of its parameter estimates are discussed.
Supplementary Material from Engineered anti-CD70 antibody-drug conjugate with increased therapeutic index (2023)

Supplementary Material from Engineered anti-CD70 antibody-drug conjugate with increased therapeutic index
Electrical conduction in water revisited: roles of field-enhanced dissociation and a reaction-based boundary condition (2003)

A one-dimensional formulation for the current density-electric field (J-E) characteristic for pure water has been developed which includes a self-consistent boundary condition, the auto-dissociation process, and electro-chemical kinetics at the electrodes. Our model results in a relatively simple form for the J-E characteristic. The predictions are shown to be in agreement with experimental data. The resulting J-E characteristics have an initial linear shape, followed by a super-linear increase. A saturating behavior is predicted based on the details of field-dependent variations in electro-chemical kinetic rates. Strong auto-dissociation would finally cause nonlinear increases at much higher applied voltages. Based on the present theory, pertinent suggestions for improving the performance of water-based gaps for pulsed power applications have been made. These include water circulation, employing surface coatings, and optical/laser excitation at the electrodes.
Unsupervised Construction of Human Body Models Using Principles of\n Organic Computing (2017)

Unsupervised learning of a generalizable model of the visual appearance of\nhumans from video data is of major importance for computing systems interacting\nnaturally with their users and others. We propose a step towards automatic\nbehavior understanding by integrating principles of Organic Computing into the\nposture estimation cycle, thereby relegating the need for human intervention\nwhile simultaneously raising the level of system autonomy. The system extracts\ncoherent motion from moving upper bodies and autonomously decides about limbs\nand their possible spatial relationships. The models from many videos are\nintegrated into meta-models, which show good generalization to different\nindividuals, backgrounds, and attire. These models allow robust interpretation\nof single video frames without temporal continuity and posture mimicking by an\nandroid robot.\n
Extracorporeal Carbon Dioxide Removal Using a Renal Replacement Therapy Platform to Enhance Lung-Protective Ventilation in Hypercapnic Patients With Coronavirus Disease 2019-Associated Acute Respiratory Distress Syndrome (2020)

Coronavirus disease 2019 (COVID-19)-associated acute respiratory distress syndrome (ARDS) is associated with high mortality. Lung-protective ventilation is the current standard of care in patients with ARDS, but it might lead to hypercapnia, which is independently associated with worse outcomes. Extracorporeal carbon dioxide removal (ECCO<sub>2</sub>R) has been proposed as an adjuvant therapy to avoid progression of clinical severity and limit further ventilator-induced lung injury, but its use in COVID-19 has not been described yet. Acute kidney injury requiring renal replacement therapy (RRT) is common among critically ill COVID-19 patients. In centers with available dialysis, low-flow ECCO<sub>2</sub>R (<500 mL/min) using RRT platforms could be carried out by dialysis specialists and might be an option to efficiently allocate resources during the COVID-19 pandemic for patients with hypercapnia as the main indication. Here, we report the feasibility, safety, and efficacy of ECCO<sub>2</sub>R using an RRT platform to provide either standalone ECCO<sub>2</sub>R or ECCO<sub>2</sub>R combined with RRT in four hypercapnic patients with moderate ARDS. A randomized clinical trial is required to assess the overall benefit and harm. <b>Clinical Trial Registration:</b> ClinicalTrials.gov. Unique identifier: NCT04351906.
Nonviral HVJ (Hemagglutinating Virus of Japan) Liposome-Mediated Retrograde Gene Transfer of Human Hypatocyte Growth Factor in the Rat Nervous System Promotes Functional and Histological Recovery of Crushed Nerve (2006)

Hepatocyte growth factor (HGF) is known to be involved in many biological functions, such as organ regeneration and angiogenesis, as well as exerting neurotrophic effects on motor, sensory, and parasympathetic neurons. In this study, the authors gave repeated intramuscular injections of the human HGF gene, using a nonviral hemagglutinating virus of Japan (HVJ) liposome method, to examine whether transfection of the rat nervous system with this gene was able to exert neurotrophic effects to facilitate recovery of a crushed nerve. The expression of HGF protein and HGF mRNA indicated that gene transfer into the nervous system did occur via retrograde axonal transport. At 4 weeks after crush, electrophysiological examination of the crushed nerve showed a significantly shorter mean latency and a significantly greater mean maximum M-wave amplitude with repeated injections of HGF gene. Furthermore, histological findings showed that the mean diameter of the axons, the axon number, and the axon population were significantly larger in the group with the repeated injections of HGF gene. The results showed that repeated human HGF gene transfer into the rat nervous system was able to promote crushed nerve recovery, both electrophysiologically and histologically, and suggested that HGF gene transfer has the potential for the treatment of human crushed nerve.
Expression of immunoproteasome genes is regulated by cell-intrinsic and –extrinsic factors in human cancers (2016)

Based on transcriptomic analyses of thousands of samples from The Cancer Genome Atlas, we report that expression of constitutive proteasome (CP) genes (PSMB5, PSMB6, PSMB7) and immunoproteasome (IP) genes (PSMB8, PSMB9, PSMB10) is increased in most cancer types. In breast cancer, expression of IP genes was determined by the abundance of tumor infiltrating lymphocytes and high expression of IP genes was associated with longer survival. In contrast, IP upregulation in acute myeloid leukemia (AML) was a cell-intrinsic feature that was not associated with longer survival. Expression of IP genes in AML was IFN-independent, correlated with the methylation status of IP genes, and was particularly high in AML with an M5 phenotype and/or MLL rearrangement. Notably, PSMB8 inhibition led to accumulation of polyubiquitinated proteins and cell death in IP<sup>high</sup> but not IP<sup>low</sup> AML cells. Co-clustering analysis revealed that genes correlated with IP subunits in non-M5 AMLs were primarily implicated in immune processes. However, in M5 AML, IP genes were primarily co-regulated with genes involved in cell metabolism and proliferation, mitochondrial activity and stress responses. We conclude that M5 AML cells can upregulate IP genes in a cell-intrinsic manner in order to resist cell stress.
Effect of catalyst distribution in a membrane reactor: Experiments and model (1997)

Abstract Inorganic membrane reactors combine reaction and separation operations in a single unit. Preferential permeation of a product species through the membrane enhances equilibrium‐limited reactions beyond the thermodynamic limit. Proper catalyst formulation and spatial distribution also enhance membrane reactor performance. To minimize reactant loss due to high gas permeation, the thickness of the γ‐alumina layer in a composite alumina membrane (Membralox) was increased to 17 μm by slip‐casting with alumina sol. Among the catalysts investigated a formulation of 1.10 wt. % Pt and 1.36 wt. % Sn supported on γ‐alumina pellets yielded the highest activity, selectivity, and stability for the dehydrogenation of ethane to ethylene. Using this catalyst composition, various nonuniform platinum distributions within the pellets were prepared by solution impregnation, while maintaining a uniform distribution of Sn. The effect of nonuniform catalyst distribution on dehydrogenation of ethane in a packed‐bed membrane reactor (PBMR) under well‐mixed, isothermal conditions was evaluated both experimentally and theoretically. Reactor performance is maximized when the catalyst is concentrated near the surface of the support. Supraequilibrium conversions, about 80% beyond equilibrium values, were obtained with the narrow surface–step catalyst pellets. Experimental results agree well with theoretical predictions, obtained without the use of any adjustable parameters. The effect of membrane thickness on reactor performance was also investigated, by comparing the 17‐μm alumina membrane with a 1.2‐mm‐thick porous Vycor glass, using pellets with the narrow surface‐step distribution. For the experimental conditions employed, relatively low permeation through the porous Vycor resulted in conversions near fixed‐bed reactor values.
Post-fabrication annealing effects in polymer-nanotube photovoltaic cells (2006)

We present a systematic study of the effects of post-fabrication annealing on the performance of photovoltaic devices that incorporate a photoactive donor–acceptor dispersed heterojunction system. Solar cells have been fabricated based on poly(3-octylthiophene) as donor (D) and single-wall carbon nanotubes as the electron acceptor (A) with a PEDOT:PSS hole transport layer. A post-fabrication annealing treatment was carried out at a temperature range of 40–200 °C. The best results were obtained at 120 °C; at this temperature the cell shows a short circuit current, Isc = 0.5 mA cm−2, an open circuit voltage, Voc = 0.75 V and a fill factor, FF = 0.6, resulting in a power conversion efficiency of η = 0.22% under AM 1.5 (100 mW cm−2) white light illumination. The annealing treatment led to a doubling of the power conversion efficiency. This was attributed to a better charge carrier transport in the polymer matrix and more effective charge separation and collection.
Practical Modeling and Simulation of Permanent Magnet Direct Current (PMDC) Motors (2003)

&lt;div class="htmlview paragraph"&gt;Electrical Computer Aided Engineering (CAE) is necessary and useful for the automotive industry [&lt;span class="xref"&gt;1&lt;/span&gt;,&lt;span class="xref"&gt;2&lt;/span&gt;]. It provides the user with necessary information that helps him/her make faster and more certain design decisions. CAE facilitates for the user options and the means to locate and choose optimums [&lt;span class="xref"&gt;6&lt;/span&gt;]. It requires models that best represent the actual system while avoiding unnecessary numerical overhead. Therefore, it is necessary to build the mathematical model in a systematic way that captures dynamics of the actual system [&lt;span class="xref"&gt;3&lt;/span&gt;]. Also, an optimal solution for the system parameters is required to increase the accuracy of the model and to make a correct decision while designing, testing, and validating [&lt;span class="xref"&gt;3&lt;/span&gt;,&lt;span class="xref"&gt;6&lt;/span&gt;]. This paper studies the CAE analysis of a PMDC motor. It develops a systematic approach to model, simulate and analyze PMDC motors with robust output. It enhances the accuracy of PMDC to a 6-Sigma level. A robust model minimizes the effort required in analyzing, predicting and validating the outcome of the motor. The uniqueness in this model is the use of Least Squares algorithm to solve for the optimal value of the motor parameters and the use for Recursive Least Squares (RLS) [&lt;span class="xref"&gt;7&lt;/span&gt; (page 70)] for On-Line learning. The use of learning overcomes a wide band of ambiguity and non-linearity included in the actual motor. The developed model introduces a procedure for calculating each of the motor parameters (e.g. R&lt;sub&gt;a&lt;/sub&gt;, L&lt;sub&gt;a&lt;/sub&gt;, K&lt;sub&gt;T&lt;/sub&gt;, K&lt;sub&gt;v&lt;/sub&gt;, J, D, T&lt;sub&gt;Loss&lt;/sub&gt;). In this paper, simulation study uses a seat motor assembly that consists of three different motors as an example. The Saber simulator is used for running the simulation study. The actual data (experimental lab results) and the estimated data (Saber model) are then compared to assure the validity of the seat motor model compared to the physical seat motor.&lt;/div&gt;
Carbon monoxide activation by organoactinides. Migratory carbon monoxide insertion into metal-hydrogen bonds to produce mononuclear formyls (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon monoxide activation by organoactinides. Migratory carbon monoxide insertion into metal-hydrogen bonds to produce mononuclear formylsPaul J. Fagan, Kenneth G. Moloy, and Tobin J. MarksCite this: J. Am. Chem. Soc. 1981, 103, 23, 6959–6962Publication Date (Print):November 1, 1981Publication History Published online1 May 2002Published inissue 1 November 1981https://doi.org/10.1021/ja00413a032RIGHTS & PERMISSIONSArticle Views496Altmetric-Citations101LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (430 KB) Get e-Alerts Get e-Alerts
Query language support for incomplete information in the MayBMS system (2007)

MayBMS [4, 1, 3, 2] is a data management system for incomplete information developed at Saarland University. Its main features are a simple and compact representation system for incomplete information and a language called I-SQL
Formation of the Dimethylbenzimidazole Ligand of Coenzyme B12 under Physiological Conditions by a Facile Oxidative Cascade (2003)

Dimethylbezimidazole, the axial ligand of vitamin B(12), is synthesized from riboflavin by a two-electron oxidation, a retro-aldol condensation, and a second two-electron oxidation. This oxidative cascade readily takes place nonenzymatically under physiological conditions. [reaction: see text]
Tracking, Profiling, and Ad Targeting in the Alexa Echo Smart Speaker Ecosystem (2023)

Smart speakers collect voice commands, which can be used to infer sensitive information about users. Given the potential for privacy harms, there is a need for greater transparency and control over the data collected, used, and shared by smart speaker platforms as well as third party skills supported on them. To bridge this gap, we build a framework to measure data collection, usage, and sharing by the smart speaker platforms. We apply our framework to the Amazon smart speaker ecosystem. Our results show that Amazon and third parties, including advertising and tracking services that are unique to the smart speaker ecosystem, collect smart speaker interaction data. We also find that Amazon processes smart speaker interaction data to infer user interests and uses those inferences to serve targeted ads to users. Smart speaker interaction also leads to ad targeting and as much as 30X higher bids in ad auctions, from third party advertisers. Finally, we find that Amazon's and third party skills' data practices are often not clearly disclosed in their policy documents.
Myxoma of the ear lobe in a 23‐month‐old girl with Carney complex (2011)

Myxomas of the ear are extremely uncommon, especially in young children. A 23-month-old girl born to a family with known Carney complex, a condition that predisposes to multiple myxomas, presented with a large, cauliflower-like mass located on the back of her right ear. Histopathologically, the lesion was composed of scattered spindle-shaped or stellate cells with abundant associated mucin and a very sparse inflammatory infiltrate containing lymphocytes and neutrophils. The patient was a carrier of a protein kinase A regulatory subunit 1A (PRKAR1A) mutation; PRKAR1A mutations cause Carney complex in most patients with this rare disorder. This is the earliest presentation of an ear lobe myxoma reported in the literature.
Evaluation Method of Gas Leakage Rate from Transportation Casks of Radioactive Materials, (II) (1994)

A sealing function is essential for transportation casks of radioactive materials in order to prevent radioactive materials from being released into the environment. In the safety analysis report, the release rate of radioactive materials into the environment is evaluated from leak path diameter and length obtained from gas leakage test. In this paper, experimental results of gas leakage rates from a very narrow orifice and a capillary tube simulating a leak path experimentally investigated using helium, argon, nitrogen and air as working fluids are presented in order to understand hydrodynamics of choked flow, non-choked free expansion flow and laminar flow in a very narrow leak path: (1) The contraction coefficient of choked flow from very narrow orifices are obtained, (2) an evaluation model of gas leakage rate from a capillary tubes is proposed, in which the acceleration loss in the entrance region, the friction loss in laminar flow with expansion effect and the exit loss for choked flow or non-choked free expansion flow are modeled, and (3) as for gas leakage rates of 10−4 to 10−2 cm3/s which are closely related to the sealing performance of transportation casks of radioactive materials, the proposed simplified evaluation method is verified for various gases.
Synthesis of Ni3S2 and NiSe nanoparticles encapsulated in carbon shell and coating these onto stainless steel surfaces by RAPET (2012)

Nickel sulfide and nickel selenide nanoparticles encapsulated in carbon shells are synthesized by the thermal decomposition of mixtures of nickel acetate and sulfur or selenium via a RAPET (Reaction under Autogenic Pressure at Elevated Temperatures) technique at 750 °C for 3 h. The synthesized products are systematically characterized by powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), and the encapsulation of Ni3S2 and NiSe nanoparticles by a carbon shell is confirmed by transmission electron micrographs (TEM). Such materials have pausible applications in photo voltaic devices, magnetic devices, in catalysis and as electrodes for batteries. Coated carbon on the surface of Ni3S2 and NiSe nanocrystals acts as a protective layer, making them thermally as well as chemically stable. Additionally, the possibility of coating a pristine stainless steel plate with Ni3S2–C core-shell composite layers is also demonstrated.
Crystal Structure of ITQ-26, a 3D Framework with Extra-Large Pores (2008)

ITQ-26 was synthesized via the fluoride procedure using 1,3-bis-(triethylphosphoniummethyl)-benzene as the structure-directing agent. The unit cell and space group were initially determined from electron diffraction experiments on individual tilted microcrystals, using material that had been sectioned by ultramicrotomy. The material crystallizes in space group I4/mmm, where after refining against synchrotron powder data (λ = 0.8714 Å), a = 26.7769(8) and c = 13.2505(5) Å. Integrated electron diffraction intensities (hk0 + 0kl) were assigned phases with the program MICE to yield electrostatic potential maps with the first informative view of the microporous framework. As a constraint for subsequent phasing trials of the powder data with FOCUS, one useful solution was found after 500 000 trials, conforming to the electron crystallographic determination. The final model, refined by Rietveld methods, comprises 7 unique T-sites forming a framework with a straight 12-MR channel along [001]. Two other 12-MR channels are tilted with respect to this one. The T-site density is 14.3 T/1000 A3.
Tendon and muscle fascicle length changes during running with compliant and stiff footwear cushioning (2019)

Keywords: cushioning (property)biomechanicsenergy returnrunningsoft tissuesStiffness (bendingorcompressive)
Patient-Reported Outcomes and Knee Mechanics Correlate With Patellofemoral Deep Cartilage UTE-T2* 2 Years After Anterior Cruciate Ligament Reconstruction (2021)

Patellofemoral deep cartilage matrix disruption, as assessed by MRI UTE-T2*, was associated with reduced sports and recreational function and with gait metrics reflective of altered patellofemoral loading. As such, the findings provide new mechanistic information important to improving clinical outcomes related to patellofemoral dysfunction after ACLR.
Effect of mTORC1/mTORC2 inhibition on T cell function: potential role in graft‐versus‐host disease control (2016)

The mechanistic target of rapamycin (mTOR) pathway is crucial for the activation and function of T cells, which play an essential role in the development of graft-versus-host disease (GvHD). Despite its partial ability to block mTOR pathway, the mTORC1 inhibitor rapamycin has shown encouraging results in the control of GvHD. Therefore, we considered that simultaneous targeting of both mTORC1 and mTORC2 complexes could exert a more potent inhibition of T cell activation and, thus, could have utility in GvHD control. To assess this assumption, we have used the dual mTORC1/mTORC2 inhibitors CC214-1 and CC214-2. In vitro studies confirmed the superior ability of CC214-1 versus rapamycin to block mTORC1 and mTORC2 activity and to reduce T cell proliferation. Both drugs induced a similar decrease in Th1/Th2 cytokine secretion, but CC214-1 was more efficient in inhibiting naïve T cell activation and the expression of T-cell activation markers. In addition, CC214-1 induced specific tolerance against alloantigens, while preserving anti-cytomegalovirus response. Finally, in a mouse model of GvHD, the administration of CC214-2 significantly improved mice survival and decreased GvHD-induced damages. In conclusion, the current study shows, for the first time, the immunosuppressive ability of CC214-1 on T lymphocytes and illustrates the role of CC214-2 in the allogeneic transplantation setting as a possible GvHD prophylaxis agent.