gebhart/patrepeval huggingface dataset:
Data from Identification of a Novel Tumor-Associated Antigen, Cadherin 3/P-Cadherin, as a Possible Target for Immunotherapy of Pancreatic, Gastric, and Colorectal Cancers (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; To establish cancer immunotherapy, it is important to identify the tumor-associated antigens (TAA) that are strongly expressed in the tumor cells but not in the normal cells. In this study, to establish an effective anticancer immunotherapy, we tried to identify the useful TAA of pancreatic cancer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Based on a previous genome-wide cDNA microarray analysis of pancreatic cancer, we focused on cadherin 3 (CDH3)/P-cadherin as a novel candidate TAA for anticancer immunotherapy. To identify the HLA-A2 (&lt;i&gt;A*0201&lt;/i&gt;)–restricted CTL epitopes of CDH3, we used HLA-A2.1 (HHD) transgenic mice (Tgm). Furthermore, we examined the cytotoxicity against the tumor cells &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; of CTLs specific to CDH3 induced from HLA-A2–positive healthy donors and cancer patients.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt;&lt;i&gt;CDH3&lt;/i&gt; was overexpressed in the majority of pancreatic cancer and various other malignancies, including gastric and colorectal cancers, but not in their noncancerous counterparts or in many normal adult tissues. In the experiment using HLA-A2.1 Tgm, we found that the CDH3-4&lt;sub&gt;655-663&lt;/sub&gt; (FILPVLGAV) and CDH3-7&lt;sub&gt;757-765&lt;/sub&gt; (FIIENLKAA) peptides could induce HLA-A2–restricted CTLs in Tgm. In addition, peptides-reactive CTLs were successfully induced from peripheral blood mononuclear cells by &lt;i&gt;in vitro&lt;/i&gt; stimulation with these two peptides in HLA-A2–positive healthy donors and cancer patients, and these CTLs exhibited cytotoxicity specific to cancer cells expressing both CDH3 and HLA-A2. Furthermore, the adoptive transfer of the CDH3-specific CTLs could inhibit the tumor growth of human cancer cells engrafted into nonobese diabetic/severe combined immunodeficiency mice.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; These results suggest that CDH3 is a novel TAA useful for immunotherapy against a broad spectrum of cancers, including pancreatic cancer.&lt;/p&gt;&lt;/div&gt;
Cathodic Disintegration as an Easily Scalable Method for the Production of Sn- and Pb-Based Catalysts for CO2 Reduction (2020)

CO2 electroreduction to formate powered by renewable energy is an attractive strategy to recycle air-based carbon. At the moment, the electrode materials showing high selectivity for formate at high current density are post transition metals such as In, Sn, Bi, and Pb. Scaling up the CO2 electroreduction technology to industrial size requires, among other things, cheap and clean methods to produce cathode materials in the form of particles to fabricate the square meters of the electrode surface area needed for the industrial electrolyzers. We show here that it is possible to easily produce catalytic powders based on Sn and Pb via a process known as cathodic disintegration, driving the reaction with electric power and avoiding the use of organic solvents, stabilizers, and reducing agents. The catalysts produced with this method are highly selective for the reduction of CO2 to formate and show promise for use in industrial electrolyzers. Moreover, the process of cathodic disintegration is quick and clean, it has a high atom efficiency, it uses dilute aqueous electrolytes as solvents, and it has the possibility to be driven by renewable energy.
In-vivo mechanical property assessment of a biodegradable polyurethane tissue construct on rat abdominal repair model using ultrasound elasticity imaging (2010)

Non-invasively monitoring the mechanical property change of the engineered tissue constructs in vivo may help evaluate and feedback tissue scaffold design. In this paper, ultrasound elasticity imaging (UEI) was applied to detect mechanical property changes of the implanted polyurethane tissue constructs on a rat abdominal defect. Bi-axial mechanical measurements on the excised tissue/scaffold constructs were performed for comparison with the UEI results. An increase in overall stiffness along with tissue ingrowth was observed in 4 and 8weeks using both UEI and direct mechanical testing. While, pure scaffold embedded in 10% gelatin showed decrease in stiffness with degradation. Histopathology confirmed tissue in growth such as collagens.
ChemInform Abstract: Tandem Vicinal Difunctionalization: β‐Addition to α,β‐ Unsaturated Carbonyl Substrates Followed by α‐Functionalization (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Full-field structured-illumination super-resolution X-ray transmission microscopy (2019)

Modern transmission X-ray microscopy techniques provide very high resolution at low and medium X-ray energies, but suffer from a limited field-of-view. If sub-micrometre resolution is desired, their field-of-view is typically limited to less than one millimetre. Although the field-of-view increases through combining multiple images from adjacent regions of the specimen, so does the required data acquisition time. Here, we present a method for fast full-field super-resolution transmission microscopy by structured illumination of the specimen. This technique is well-suited even for hard X-ray energies above 30 keV, where efficient optics are hard to obtain. Accordingly, investigation of optically thick specimen becomes possible with our method combining a wide field-of-view spanning multiple millimetres, or even centimetres, with sub-micron resolution and hard X-ray energies.
Diabetic Neuropathies (2008)

Diabetic neuropathies (DN) are a heterogeneous group of disorders that include a wide range of abnormalities. They can be focal or diffuse, proximal or distal, affecting both peripheral and autonomic nervous systems, causing morbidity with significant impact on the quality of life of the person with diabetes, resulting in early mortality. Distal symmetric polyneuropathy, the most common form of DN, usually involves small and large nerve fibers. Small nerve fiber neuropathy often presents with pain without objective signs or electrophysiologic evidence of nerve damage. However, there are now measures enabling early recognition of this type of neuropathy as a component of the impaired glucose tolerance and metabolic syndromes. The greatest risk of small fiber neuropathy is foot ulceration and subsequent gangrene and amputation. Large nerve fiber neuropathies produce numbness, ataxia and incoordination, impairing activities of daily living and causing falls and fractures. A careful history and detailed physical examination is essential for the diagnosis. Symptomatic therapy has become available, and newer and better treatment modalities based on etiologic factors are being explored with potential for significant impact on morbidity and mortality. Preventive strategies and patient education still remain key factors in reducing complication rates and mortality. A number of mechanical measures for the treatment of neuropathy have been examined, and it is currently unclear whether or not these have salutary effects over and above those of placebo, and longer, well-controlled clinical trials are anticipated. In addition, there is the suggestion that surgical unentrapment of nerves in DN may confer symptomatic relief, but outside of clear applications in proven entrapments, this form of intervention has not been endorsed universally. We now have two drugs approved for the treatment of neuropathic pain in diabetes that is a first, and it remains to be seen whether the evidence-based approach will supersede the need for cost containment and the tried and tested approaches to pain management in the clinic. Finally, the American Diabetes Association have included somatic and autonomic guidelines in their 2006 issue of clinical recommendations, which has come as a welcome relief to the Cinderella of diabetic complications, DN.
Shape memory alloys for civil engineering structures - on the way from vision to reality (2009)

Shape memory alloys (SMA) have been known for many decades. They are mainly used in medicine, electronics, air, and space industry and in the consumer goods industry. Examples are medical implants and instruments, cell phone antennas, frames for glasses, pipe couplings etc. The most usual SMA material on the market is nickel–titanium (Ni–Ti). Until today, SMAs have found very limited applications in civil engineering probably due to their cost and to limited knowledge of the material in the civil engineering industry.&lt;br /&gt;This paper will present existing applications, laboratory tests and new concepts of how to use shape memory alloys incorporated in energy dissipation devices, as well as for pre-stressing structures using SMA wires and for post stressing of existing structures using SMA tendons. Attempts to develop new generation of Iron based SMA for using in civil engineering structures will be presented as an alternative to existing high cost NiTi SMAs.
Synthetic Bile Acids: Novel Mediators of Apoptosis (2002)

Summary and implications In this paper, we outlined the current understanding of naturaland synthetic bile acid signaling in apoptosis. Much insightwas gained in recent years, particularly with respect to theinducers of the hydrophobic bile acid signaling cascade.Moreover, the newly synthesized bile acids also inducedapoptosis in several human cancer cells, which were notderived from hepatocytes, cholangiocytes, and ilealenterocytes. Therefore, the new synthetic bile acids might beapplicable novel apoptosis mediators for the treatment ofvarious cancer cells.In human breast and prostate cancer cells with differenttumor suppressor p53 status, the synthetic bile acid derivative-induced growth inhibition and apoptosis were associated withthe up-regulation of Bax and p21 WAF1/CIP1 , and the effects weremediated via a p53-inpendent pathway. In Jurkat human T cellleukemia, the synthetic bile acid derivatives induced apoptosisthrough caspase activation. Additionly, the synthetic bile acidsinduced apoptosis in a JNK dependent manner in SiHa humancervical cancer cells, PC3 prostate cancer cells, HT29 coloncancer cells, and TE671 brain tumor cells (Im, E.O., Yoo,Y.H., and Kim, N.D., unpublished data).Alterations in cell survival play a critical role for thepathogenesis of various human diseases, including cancer(Thompson, 1995). Administration of modified bile acids thatinduce apoptosis might represent a rational therapy for tumorsthat originate from several different types of cells. Therefore,these novel derivatives of bile acids may represent promisingchemical entities, which specifically target various cancercells by triggering apoptosis. These could be important leadcompounds for the development of new anticancer agents thatare based on the structure of bile acids.Acknowledgments This work was supported by grant No.R01-2001-00145 from the Korea Science & EngineeringFoundation and by a Pusan National University ResearchGrant.
The IL-1 Family Member 7b Translocates to the Nucleus and Down-Regulates Proinflammatory Cytokines (2008)

The IL-1 family member 7b (IL-1F7b) is a novel homolog of the IL-1 cytokine family discovered by computational cloning. We have reported that IL-1F7b shares critical amino acid residues with IL-18 and binds the IL-18-binding protein; in doing so, IL-1F7b augments the inhibition of IFN-gamma by the IL-18-binding protein. IL-1F7b also binds IL-18Ralpha but neither induces signal nor acts as a receptor antagonist. Hence, the function of IL-1F7b remains unknown. In the present study, we analyzed the intracellular expression pattern of IL-1F7b. Using two variants of GFP fusion constructs of human IL-1F7b stably expressed in RAW macrophages, only the postcleavage mature form of the IL-1F7b precursor-but not the N-terminal propiece-specifically translocates to the nucleus following LPS stimulation. IL-1F7b, like IL-1beta, IL-18, and IL-33, is processed by caspase-1 to generate the mature cytokines. Therefore, we tested whether caspase-1-mediated cleavage of the IL-1F7b precursor is required for mature IL-1F7b to translocate actively into the nucleus. Indeed, a specific caspase-1 inhibitor markedly reduced nuclear entry of IL-1F7b. In stable transfectants of human IL-1F7b in RAW macrophages stimulated with LPS, levels of TNF-alpha, IL-1alpha, IL-6, as well as the chemokine MIP-2, were substantially reduced (72-98%) compared with LPS-stimulated cells transfected with the empty plasmid. These results demonstrate that IL-1F7b translocates to the nucleus after caspase-1 processing and may act as a transcriptional modulator reducing the production of LPS-stimulated proinflammatory cytokines, consistent with IL-1F7b being an anti-inflammatory member of the IL-1 family.
ChemInform Abstract: Oxidation of Sulfides by Molecular Oxygen—Aldehyde System in the Absence of Metal Catalyst. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Long term effects on human plasma lipoproteins of a formulation enriched in butter milk polar lipid (2009)

The study did not show any significant decrease on plasma lipids or lipoprotein levels of an SL-enriched formulation containing 2-3 times more SL than the normal dietary intake on cholesterol, other plasma lipids or on energy intake. The formulation A may, however, have counteracted the trend towards increased blood lipid concentrations caused by increased energy intake that was seen with the B formulation.
Effect of 5-Hydroxytryptophan on Prolactin and Growth Hormone Release in the Infant Rat: Evidence for Different Neurotransmitter Mediation (1977)

In 10 day-old female and male rats, administration of 5-hydroxytryptophan (5-HTP) induced a prompt elevation in plasma prolactin (Prl) and growth hormone (GH) levels. Pretreatment with 2 serotonin (5-HT) receptor blockers, methysergide (Meth) and metergoline (MCE), markedly reduced the 5-HTP-induced Prl rise but failed to alter the GH response to 5-HTP. Administration of 2 selective inhibitors of presynaptic 5-HT reuptake, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenyl-ρropylamine and chlorimipramine (CIM), potentiated the 5-HTP-stimulated Prl rise but significantly reduced the 5-HTP-induced GH release. Blockade of dopaminergic or α-adrenergic receptors by pretreatment with pimozide (Pim) or phentolamine (Phent), respectively, or central sympathectomy by intraventricularly (i.vt.) injected 6-hydroxydopamine (6-OHDA) were capable of reducing the 5-HTP-induced GH release without affecting the 5-HTP-induced Prl rise. These data indicate that in the infant rat the 5-HTP-induced Prl release is mediated via the brain 5-HT system and that a nonspecific activation of the catecholaminergic system is responsible for the GH response to the drug.
Separation of simian virus 40 large-T-antigen-transforming and origin-binding functions from the ability to block differentiation. (1988)

Wild-type simian virus 40 large T antigen is very effective at blocking adipocyte differentiation in 3T3-F442A cells as assayed by triglyceride accumulation, induction of glycerophosphate dehydrogenase activity, and expression of mRNAs for glycerophosphate dehydrogenase, the adipocyte serine protease adipsin, and the putative lipid-binding protein adipocyte P2. Point mutants defective for either origin-specific DNA binding or transformation blocked differentiation as completely as wild type.
Thermochemically based strategies for carbon-hydrogen activation on saturated hydrocarbon molecules. Ring-opening reactions of a thoracyclobutane with tetramethylsilane and methane (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermochemically based strategies for carbon-hydrogen activation on saturated hydrocarbon molecules. Ring-opening reactions of a thoracyclobutane with tetramethylsilane and methaneCarol M. Fendrick and Tobin J. MarksCite this: J. Am. Chem. Soc. 1984, 106, 7, 2214–2216Publication Date (Print):April 1, 1984Publication History Published online1 May 2002Published inissue 1 April 1984https://pubs.acs.org/doi/10.1021/ja00319a054https://doi.org/10.1021/ja00319a054research-articleACS PublicationsRequest reuse permissionsArticle Views319Altmetric-Citations86LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Minimally Invasive Lateral Access Surgery for Symptomatic Thoracic Disc Herniation: Initial Clinical Experience with Clinical and Radiographic Outcomes (2011)

Introduction Symptomatic herniated thoracic discs remain a surgical challenge and historically have been associated with high levels of complications. While the neurologic outcomes have improved with the abandonment of the decompressive laminectomy; surgical complications, morbidity and the need for fusion have continued. The purpose of this study is to demonstrate the safety and reproducibility of the minimally invasive lateral thoracic approach for symptomatic thoracic herniated intervertebral discs with clinical and radiological outcomes.
Radical Initiated Hydrosilylation on Silicon Nanocrystal Surfaces: An Evaluation of Functional Group Tolerance and Mechanistic Study (2015)

Hydrosilylation is among the most common methods used for modifying silicon surface chemistry. It provides a wide range of surface functionalities and effective passivation of surface sites. Herein, we report a systematic study of radical initiated hydrosilylation of silicon nanocrystal (SiNC) surfaces using two common radical initiators (i.e., 2,2'-azobis(2-methylpropionitrile) and benzoyl peroxide). Compared to other widely applied hydrosilylation methods (e.g., thermal, photochemical, and catalytic), the radical initiator based approach is particle size independent, requires comparatively low reaction temperatures, and yields monolayer surface passivation after short reaction times. The effects of differing functional groups (i.e., alkene, alkyne, carboxylic acid, and ester) on the radical initiated hydrosilylation are also explored. The results indicate functionalization occurs and results in the formation of monolayer passivated surfaces.
Hydrides (2016)

The article contains sections titled: 1. Introduction 2. Hydrides of the Alkali and Alkaline Earth Metals 2.1. General 2.2. Lithium Hydride 2.3. Sodium Hydride 2.4. Potassium Hydride 2.5. Beryllium Hydride 2.6. Magnesium Hydride 2.7. Calcium Hydride 3. Binary and Complex Hydrides of the Boron Group 3.1. General 3.2. Lithium Tetrahydridoborate 3.3. Lithium Triethylhydridoborate 3.3. Lithium Tri-sec-butylhydridoborate 3.4. Sodium Tetrahydridoborate 3.5. Sodium Cyanotrihydridoborate 3.6. Potassium Tetrahydridoborate 3.7. Aluminum Hydride 3.8. Lithium Tetrahydridoaluminate 3.9. Lithium (tri-tert-butoxy)hydrido-aluminate 3.10. Sodium Tetrahydridoaluminate 3.11. Sodium bis(2-methoxyethoxy)dihydridoaluminate 3.12. Diisobutylaluminum Hydride 4. Hydrides of the Transition Metals 4.1. Binary Hydrides 4.1.1. Titanium Hydride 4.1.2. Zirconium Hydride 4.2. Intermetallic Hydrides 4.3. Complex Hydrides of Transition Metals 4.3.1. Di(η5-cyclopentadienyl)chlorohydridozirconium(IV) 4.3.2. Carbonylhydrido-tris(triphenylphosphine)rhodium(I) 5. Use of complex hydrides for organic synthesis 5.1. Overview 5.2. Chemoselective Reductions 5.3. Enantioselective Reductions 6. Use of metal hydrides for energy storage 6.1. Hydrogen Storage 6.1.1. Reversible Hydrogen storage 6.1.2. Non-reversible Hydrogen storage 6.2. Thermochemical applications 6.3. Battery applications 7. Handling, Storage, and Transportation 8. Toxicology and Occupational Health
Poster Abstract (2010)

Mobile users face privacy risks when providing their locations to untrusted location based services (LBSs). We develop CacheCloak, a system that enables realtime anonymization of location data. A trusted anonymizing server receives the location of a user, processes it using CacheCloak, and exposes the processed data to LBSs. We show that the quality of the location data does not degrade in space or time, and hence, LBSs are able to respond accurately in real time. Yet, privacy is preserved as LBSs are unable to track any given user for more than a short duration. The key is to exploit mobility patterns to intelligently extrapolate each user's path until it meets another. A snapshot of intersecting paths is sent to the LBS, preventing reliable tracking of any given user. We use stochastic methods to generate mobility predictions and entropy measurements to quantify a user's anonymity. We demonstrate a high tracking resilience against a reasonably powerful adversary. Tracebased traffic simulation using real GIS data shows that CacheCloak can achieve realtime location privacy without degrading location accuracy or service availability.
Correlation of cell surface marker expression with African swine fever virus infection (2013)

The expression of surface markers on African swine fever virus (ASFV) infected cells was evaluated to assess their involvement in infection. Previous findings indicated CD163 expression was correlated with ASFV susceptibility. However, in this study the expression of porcine CD163 on cell lines did not increase the infection rate of these cells indicating other factors are likely to be important in determining susceptibility to infection. On adherent porcine bone marrow (pBM) cells the expression of CD45 was strongly correlated with infection. CD163 and CD203a expression correlated at intermediate levels with infection, indicating cells expressing these markers could become infected but were not preferentially infected by the virus. Most of the cells expressing MHCII were infected, indicating that they may be preferentially infected although expression of MHCII was not essential for infection and a large percentage of the infected cells were MHCII negative. CD16 showed a marked decrease in expression following infection and significantly lower levels of infected cells were shown to express CD16. Altogether these results suggest CD163 may be involved in ASFV infection but it may not be essential; the results also highlight the importance of other cell markers which requiring further investigation.