gebhart/patrepeval huggingface dataset:
Ischemia-induced loss of epithelial polarity. Role of the tight junction. (1989)

In proximal tubular cells ischemia is known to result in the redistribution of apical and basolateral domain-specific lipids and proteins into the alternate surface membrane domain. Since tight junctions are required for the maintenance of surface membrane polarity, the effect of ischemia on tight junction functional integrity was investigated. In vivo microperfusion of early loops of proximal tubules with ruthenium red (0.2%) in glutaraldehyde (2%) was used to gain selective access to and outline the apical surface membrane. Under control situations ruthenium red penetrated less than 10% of the tight junctions. After 5, 15, and 30 min of ischemia, however, there was a successive stepwise increase in tight junction penetration by ruthenium red to 29, 50, and 62%, respectively. This was associated with the rapid duration-dependent redistribution of basolateral membrane domain-specific lipids and NaK-ATPase into the apical membrane domain. Taken together, these data indicate that during ischemia proximal tubule tight junctions open, which in turn leads to the lateral intramembranous diffusion of membrane components into the alternate surface membrane domain.
Fumarate Hydratase Variants and Their Association With Paraganglioma/Pheochromocytoma (2023)

Certain FH variants confer an increased risk of PGL/PCC, but not necessarily HLRCC. While universal screening for PGL/PCC among all individuals with FH variants does not appear warranted, it should be considered in select high-risk PGL/PCC FH variants.
ChemInform Abstract: Emerimicins III and IV and Their Ethylalanine12 Epimers. Facilitated Chemical‐Enzymatic Synthesis and a Qualitative Evaluation of Their Solution Structures (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Engineering Magnetic Properties of Superconducting Microstrip Resonators via the Proximity Effect (2018)

We explore the magnetic field dependent microwave losses of Al/Nb/Al heterostructure superconducting microstrip resonators. We control the proximity effect through the Al layer thickness. For applications in X-band electron spin resonance of g = 2 electron spin systems, 5 nm Al cladding on 50 nm Nb resonator is found to show a higher quality factor in the design field than either a 10 nm cladding or a device without Al cladding. In addition, we find that Al cladding reduces the loss arising from vortex motion by decreasing the viscous drag coefficient and enhancing the vortex pinning potential.
Chemoenzymatic Dynamic Kinetic Resolution of Amines in Fully Continuous-Flow Mode (2018)

In this study, lipase-mediated dynamic kinetic resolution (DKR) of various benzylic amines (1a-g) is presented which is realized in a so far unprecedented fully continuous-flow system. The DKR process applying sol-gel immobilized lipase B from Candida antarctica as biocatalyst, palladium on 3-aminopropyl-functionalized silica as racemization catalyst, isopropyl 2-ethoxyacetate as acylating agent, ammonium formate as hydrogen and nitrogen sources, and 2-methyl-2-butanol as solvent under regulated pressure provided the desired products in moderate to good yields with excellent enantiomeric excesses.
A phase Ib trial of an anti-idiotypic vaccine for Lewis Y (IGN 301) administered subcutaneously in patients with refractory solid tumors (2004)

2586 Background: The Lewis Y (LeY) antigen is expressed on 60–90% of solid tumors with limited expression on normal tissue. This property has attracted interest to use LeY antigen as a vaccine in cancer immunotherapy. Use of an anti-idiotypic antibody (IGN 301) as an immunogenic surrogate for the LeY antigen is hypothesized to elicit a strong IgG response. We are conducting a phase I trial of IGN 301 to determine the safety, immunologic effects and antitumor activity with and without GM-CSF or IFN-α2b. Methods: Twenty-eight patients with solid tumor refractory to standard therapy enrolled in 2 cohorts. Cohort 1 received vaccine alone and cohort 2 received vaccine plus colony stimulating factor (GM-CSF). The immunogenicity of IGN 301 was assessed by measurement of the total humoral immune response. Seroconversion was assayed by ELISA and defined as a serum Ig titer of at least 1:100 against the murine type anti-idiotypic antibody used as vaccine antigen in IGN 301. T-cell reactivity was assessed by ELISPOT. Peripheral blood lymphocytes (PBLs) were isolated by Ficoll centrifugation and then tested for reaction against IGN 301, LeY and a series of positive and negative controls. Results: No patient experienced greater than grade 2 toxicity. Cohort 1 had a 64% seroconversion rate (9/14 patients) and cohort 2 had 60% (3/5 patients). T-cell reactivity was more frequent in cohort 1 (43%) versus cohort 2 (14%). The most frequent response observed was a Th1 phenotype (IFN-γ response). Only one patient from all evaluable was observed to have a Th2 (IL-4) response. Conclusions: IGN 301 was well tolerated without significant toxicities. Immunization induced a high rate of antibody seroconversion. Elicited T-cell immune response was predominantly Th1 phenotype. Further evaluation will assess the role and toxicity of IFN-α2b administration as an adjuvant with this vaccine. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Igeneon Igeneon
Identification of Differentially Expressed Proteins in Direct Expressed Prostatic Secretions of Men with Organ-confined Versus Extracapsular Prostate Cancer (2012)

Current protocols for the screening of prostate cancer cannot accurately discriminate clinically indolent tumors from more aggressive ones. One reliable indicator of outcome has been the determination of organ-confined versus nonorgan-confined disease but even this determination is often only made following prostatectomy. This underscores the need to explore alternate avenues to enhance outcome prediction of prostate cancer patients. Fluids that are proximal to the prostate, such as expressed prostatic secretions (EPS), are attractive sources of potential prostate cancer biomarkers as these fluids likely bathe the tumor. Direct-EPS samples from 16 individuals with extracapsular (n = 8) or organ-confined (n = 8) prostate cancer were used as a discovery cohort, and were analyzed in duplicate by a nine-step MudPIT on a LTQ-Orbitrap XL mass spectrometer. A total of 624 unique proteins were identified by at least two unique peptides with a 0.2% false discovery rate. A semiquantitative spectral counting algorithm identified 133 significantly differentially expressed proteins in the discovery cohort. Integrative data mining prioritized 14 candidates, including two known prostate cancer biomarkers: prostate-specific antigen and prostatic acid phosphatase, which were significantly elevated in the direct-EPS from the organ-confined cancer group. These and five other candidates (SFN, MME, PARK7, TIMP1, and TGM4) were verified by Western blotting in an independent set of direct-EPS from patients with biochemically recurrent disease (n = 5) versus patients with no evidence of recurrence upon follow-up (n = 10). Lastly, we performed proof-of-concept SRM-MS-based relative quantification of the five candidates using unpurified heavy isotope-labeled synthetic peptides spiked into pools of EPS-urines from men with extracapsular and organ-confined prostate tumors. This study represents the first efforts to define the direct-EPS proteome from two major subclasses of prostate cancer using shotgun proteomics and verification in EPS-urine by SRM-MS.
Improved High‐Brightness Efficiency of Phosphorescent Organic LEDs Comprising Emitter Molecules with Small Permanent Dipole Moments (2010)

Weaker triplet-triplet annihilation (TTA) is observed in organic solid mixed systems comprising the phosphorescent emitter Ir(ppy)2(acac), which has a smaller dipole moment than the reference compound Ir(ppy)3. Spectral and time-resolved analysis show that the weaker TTA can be explained by lower emitter aggregation, which reduces diffusion-based TTA.
Synthesis of Structurally Stable Colloidal Composites as Magnetically Recyclable Acid Catalysts (2010)

In this study, we provide a simple and reproducible method for the preparation of highly active and recyclable colloidal acid catalysts. First, 16-heptadecenoic acid-functionalized magnetite nanoparticles were encapsulated in monodisperse cross-linked polymer spheres. This was achieved by emulsion copolymerization technique in an aqueous phase of styrene and divinylbenzene (DVB). Different ratios of styrene and DVB were used to tune the structural stability and surface morphology of the composites. With increase in DVB content, the surfaces of the colloidal composites become increasingly rougher. The obtained colloids were functionalized with sulfonic acid groups to obtain magnetically recyclable catalysts with H+ contents in the range of 2.2−2.5 mmol g−1 and surface areas of 45−120 m2 g−1. For the condensation reaction of benzaldehyde and ethylene glycol, magnetic acid catalyst prepared only from DVB precursor was found to be active and with high selectivity and long-term stability.
Water as a tuneable solvent: a perspective (2020)

Water is the sustainable solvent of excellence, but its high polarity limits the solubility of non-polar compounds. Confinement of water in hydrophobic pores alters its hydrogen bonding structure and related properties such as dielectric constant and solvation power. Whether this special state of confined water can be rendered useful in chemical processes is hitherto underexplored. Confining water in hydrophobic nanopores could be a way to modulate water solvent properties, enabling the use of water as a tuneable solvent (WaTuSo). Applying pressure forces a heterogeneous mixture of poorly soluble molecules and water into hydrophobic nanopores of a host material where the lowered polarity of water enhances dissolution. Decompression after reaction causes expulsion of the solution from the pores and spontaneous demixing of reaction products because water returns to its normal polar state. Temporary dissolution enhancement during confinement is expected to be advantageous to chemical reaction and molecular storage. Nano-confined water offers a potential alternative to compression for storing CH<sub>4</sub> and H<sub>2</sub> gas, and opens new opportunities for green chemistry such as aqueous phase hydrogenation reactions which benefit from enhanced hydrogen solubility. Unprecedented control in time and space over H<sub>2</sub>O solvation properties in a WaTuSo system will enable new technologies with major scientific and societal impact.
Alkoxide-functionalized cyclopentadienyl complexes of yttrium containing a two-carbon tether (2002)

The ligand C 5 H 4 (CH 2 CH 2 CAr F 2 OH) (3) (Ar F = 3,5-C 6 H 3 (CF 3 ) 2 ) was prepared in two steps, from the iodo ester ICH 2 CH 2 CO 2 Me by way of the cyclopentadienyl ester C 5 H 5 CH 2 CH 2 CO 2 Me (2), in 55% overall yield. Thermal reaction of 3 with {Y[N(SiMe 3 ) 2 ] 2 (THF) 2 (µ-Cl)} 2 afforded the neutral chloride complex {η 5 :η 1 -C 5 H 4 [CH 2 CH 2 C(O)(3,5-C 6 H 3 (CF 3 ) 2 ) 2 ]}YCl{THF} n (5a: n = 2, 5b: n = 1). Metathesis reactions of 5 with 1 equiv of NaN(SiMe 3 ) 2 , LiO-2,6-t-Bu 2 C 6 H 3 , and LiCH(SiMe 3 ) 2 afforded {η 5 :η 1 -C 5 H 4 [CH 2 CH 2 C(O)(3,5-C 6 H 3 (CF 3 ) 2 ) 2 ]}Y{N(SiMe 3 ) 2 }{THF} n (6), {η 5 :η 1 -C 5 H 4 [CH 2 CH 2 C(O)(3,5-C 6 H 3 (CF 3 ) 2 ) 2 ]}Y{O-2,6-t-Bu 2 C 6 H 3 }{THF} n (7), and {η 5 :η 1 -C 5 H 4 [CH 2 CH 2 C(O)(3,5-C 6 H 3 (CF 3 ) 2 ) 2 ]}Y{CH(SiMe 3 ) 2 }{THF} n (8), respectively, (a: n = 2, b: n = 1). Exposure of the bis(THF) solvates to reduced pressure resulted in desolvation to the mono(THF) adducts for 58. The solid state structure of 6b was established by X-ray crystallography. In addition, formation of a spirocyclic ether (C 4 H 6 CH 2 CH 2 C(O)(3,5-C 6 H 3 (CF 3 ) 2 ) 2 4), obtained by the intramolecular cyclization of ligand 3, was confirmed by X-ray crystallography. Key words: yttrium, organometallic, cyclopentadienyl, X-ray, alkoxide, chelate, alkyl, hybrid ligand, NMR, cyclization.
Chemical Solution Deposition (CSD) (2019)

Abstract Chemical solution deposition (CSD) can offer economic access to large area coatings, which are required to handle significant amounts of energy in innovative applications. CSD represents an umbrella term encompassing various methods such as sol–gel, metallo‐organic decomposition (MOD), and chemical bath deposition (CBD), which are used for the fabrication of functional metal chalcogenide films. These methods are all based on the layer fabrication from precursors dissolved in the liquid phase, which are transformed into the final functional film material by different working principles. The differences are related to the involved chemistry, solvent, temperatures, and heating processes, as described herein. In addition, chemical and physical deposition methods are briefly compared, highlighting their advantages and disadvantages.
Gene amplification and altered enzymes as mechanisms for the development of drug resistance. (1983)

Two known mechanisms by which neoplastic cells may become resistant to chemotherapeutic agents are reviewed, using methotrexate (MTX) resistance as a model. These mechanisms are an increased level of target enzyme, found in several instances to be a consequence of gene amplification, or an altered target enzyme or receptor, less capable of binding the drug. An example of MTX resistance due to low-level gene amplification in leukemia cells from an MTX-resistant patient is described. Strategies for selectively eradicating these resistant cell populations may be formulated based on the mechanism by which these cells became drug-resistant.
An integrated genomic and transcriptomic survey of mucormycosis-causing fungi (2016)

Mucormycosis is a life-threatening infection caused by Mucorales fungi. Here we sequence 30 fungal genomes, and perform transcriptomics with three representative Rhizopus and Mucor strains and with human airway epithelial cells during fungal invasion, to reveal key host and fungal determinants contributing to pathogenesis. Analysis of the host transcriptional response to Mucorales reveals platelet-derived growth factor receptor B (PDGFRB) signaling as part of a core response to divergent pathogenic fungi; inhibition of PDGFRB reduces Mucorales-induced damage to host cells. The unique presence of CotH invasins in all invasive Mucorales, and the correlation between CotH gene copy number and clinical prevalence, are consistent with an important role for these proteins in mucormycosis pathogenesis. Our work provides insight into the evolution of this medically and economically important group of fungi, and identifies several molecular pathways that might be exploited as potential therapeutic targets.
ChemInform Abstract: Synthesis of the Major Metabolic Dihydrodiols (I) ‐ (III) of Benzo(j)fluoranthene (IV). (1987)

ChemInformVolume 18, Issue 41 Isocyclic Compounds ChemInform Abstract: Synthesis of the Major Metabolic Dihydrodiols (I) - (III) of Benzo(j)fluoranthene (IV). J. E. RICE, J. E. RICE Pioneer. Res. Dep., Clorox Techn. Center, Pleasanton, CA 94566, USASearch for more papers by this authorH.-C. SHIH, H.-C. SHIH Pioneer. Res. Dep., Clorox Techn. Center, Pleasanton, CA 94566, USASearch for more papers by this authorN. HUSSAIN, N. HUSSAIN Pioneer. Res. Dep., Clorox Techn. Center, Pleasanton, CA 94566, USASearch for more papers by this authorE. J. LAVOIE, E. J. LAVOIE Pioneer. Res. Dep., Clorox Techn. Center, Pleasanton, CA 94566, USASearch for more papers by this author J. E. RICE, J. E. RICE Pioneer. Res. Dep., Clorox Techn. Center, Pleasanton, CA 94566, USASearch for more papers by this authorH.-C. SHIH, H.-C. SHIH Pioneer. Res. Dep., Clorox Techn. Center, Pleasanton, CA 94566, USASearch for more papers by this authorN. HUSSAIN, N. HUSSAIN Pioneer. Res. Dep., Clorox Techn. Center, Pleasanton, CA 94566, USASearch for more papers by this authorE. J. LAVOIE, E. J. LAVOIE Pioneer. Res. Dep., Clorox Techn. Center, Pleasanton, CA 94566, USASearch for more papers by this author First published: October 13, 1987 https://doi.org/10.1002/chin.198741196AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume18, Issue41October 13, 1987 RelatedInformation
Analysis of classical neutrophils and polymorphonuclear myeloid-derived suppressor cells in cancer patients and tumor-bearing mice (2021)

In this study, using single-cell RNA-seq, cell mass spectrometry, flow cytometry, and functional analysis, we characterized the heterogeneity of polymorphonuclear neutrophils (PMNs) in cancer. We describe three populations of PMNs in tumor-bearing mice: classical PMNs, polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs), and activated PMN-MDSCs with potent immune suppressive activity. In spleens of mice, PMN-MDSCs gradually replaced PMNs during tumor progression. Activated PMN-MDSCs were found only in tumors, where they were present at the very early stages of the disease. These populations of PMNs in mice could be separated based on the expression of CD14. In peripheral blood of cancer patients, we identified two distinct populations of PMNs with characteristics of classical PMNs and PMN-MDSCs. The gene signature of tumor PMN-MDSCs was similar to that in mouse activated PMN-MDSCs and was closely associated with negative clinical outcome in cancer patients. Thus, we provide evidence that PMN-MDSCs are a distinct population of PMNs with unique features and potential for selective targeting opportunities.
Natural van der Waals heterostructural single crystals with both magnetic and topological properties (2019)

Heterostructures having both magnetism and topology are promising materials for the realization of exotic topological quantum states while challenging in synthesis and engineering. Here, we report natural magnetic van der Waals heterostructures of (MnBi<sub>2</sub>Te<sub>4</sub>) <i><sub>m</sub></i> (Bi<sub>2</sub>Te<sub>3</sub>) <i><sub>n</sub></i> that exhibit controllable magnetic properties while maintaining their topological surface states. The interlayer antiferromagnetic exchange coupling is gradually weakened as the separation of magnetic layers increases, and an anomalous Hall effect that is well coupled with magnetization and shows ferromagnetic hysteresis was observed below 5 K. The obtained homogeneous heterostructure with atomically sharp interface and intrinsic magnetic properties will be an ideal platform for studying the quantum anomalous Hall effect, axion insulator states, and the topological magnetoelectric effect.
Metallkomplexe in Biologie und Medizin, V. Neue Hydroxycarboxylat‐Komplexe von Bismut. Synthese und Struktur von Bismut(III)‐malat‐monohydrat und Bismut(III)‐tartrat‐trihydrat (1993)

Metal Complexes in Biology and Medicine, V. — New Bismuth Hydroxycarboxylate Complexes. Synthesis and Structure of Bismuth(III) Malate Monohydrate and Bismuth(III) Tartrate Trihydrate Reaction of Bi(NO 3 ) 3 · 5 H 2 O with L ‐(–)‐malic acid results in the formation of bismuth(III) malate monohydrate Bi[O 2 CCH 2 CH(O)CO 2 ] · H 2 O ( 1 ) containing the tridentate ligand [ L ‐(–)‐malate] 3– with all donating functions deprotonated. By way of contrast, reaction of Bi(NO 3 ) 3 · 5 H 2 O with L ‐(+)‐tartraic acid gives bismuth(III) tartrate trihydrate ( 2 ), in which two different tartrate ligands, [ L ‐(+)‐tartrate] 1– and [ L ‐(+)‐tartrate] 2– are present. The solid‐state structures have been determined by single‐crystal X‐ray methods and confirmed by powder diffraction measurements. The structure analyses exhibit a three‐dimensional network in the crystalline state resulting from bridging and chelating properties of the polydentate hydroxycarboxylate ligands. Bismuth shows high coordination numbers.
RFC 6676: multicast addresses for documentation (2012)

This document discusses which multicast addresses should be used for documentation purposes and reserves multicast addresses for such use. Some multicast addresses are derived from AS numbers or unicast addresses. This document also explains how these can be used for documentation purposes.
A shared service algorithm for a trunked mobile system (1986)

A model has been developed and solved which captures the essence of the concept of mobile dispatch service. There are two types of users, dispatch and interconnect (calls routed from the public switched telephone network, of much longer holding times). Also, only some of the available repeaters can be used for interconnect traffic, and blocked interconnect calls are cleared. Dispatch calls, however, can access all repeaters, and then are queued if all repeaters are busy. One design decision involves a trade between blocking of interconnect calls and queueing of dispatch calls. A formula has been derived for both interconnect blocking probability and the mean dispatch queueing time to permit this trade. The results indicate that a good operating point is to have (N - a <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</inf> )(rounded down) interconnected repeaters, where there are N total repeaters and a <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</inf> Erlangs of dispatch traffic.
DeFMO: Deblurring and Shape Recovery of Fast Moving Objects (2021)

Objects moving at high speed appear significantly blurred when captured with cameras. The blurry appearance is especially ambiguous when the object has complex shape or texture. In such cases, classical methods, or even humans, are unable to recover the object’s appearance and motion. We propose a method that, given a single image with its estimated background, outputs the object’s appearance and position in a series of sub-frames as if captured by a high-speed camera (i.e. temporal super-resolution). The proposed generative model embeds an image of the blurred object into a latent space representation, disentangles the background, and renders the sharp appearance. Inspired by the image formation model, we design novel self-supervised loss function terms that boost performance and show good generalization capabilities. The proposed DeFMO method is trained on a complex synthetic dataset, yet it performs well on real-world data from several datasets. DeFMO outperforms the state of the art and generates high-quality temporal super-resolution frames.