gebhart/patrepeval huggingface dataset:
Impact of domain depth on SAW generation by acoustic superlattice transducer in 128&#x00B0; YX-cut lithium niobate (2013)

Surface acoustic wave (SAW) generation on 128° YX acoustic superlattice has been investigated by considering the finite-depth of the domain created by the UV direct-domain writing. We found that bound and localized SAW will be generated when the domain depth of the ASL structure, underlying the transducer, is smaller and bigger than the lattice period, respectively. Efficient bound SAW can be achieved, provided the domain depth is 30% of the lattice period.
Report on the INEX 2007 Multimedia Track (2007)

The INEX Multimedia track focuses on using the structure of XML documents to extract, relate, and combine the relevance of different multimedia fragments. This paper presents a brief overview of the track for INEX 2007, including the track's test collection, tasks, and goals. We also report the approaches of the participating groups and their main results.
VidWiki (2014)

Videos are becoming an increasingly popular medium for communicating information, especially for online education. Recent efforts by organizations like Coursera, edX, Udacity and Khan Academy have produced thousands of educational videos with hundreds of millions of views in their attempt to make high quality teaching available to the masses. As a medium, videos are time-consuming to produce and cannot be easily modified after release. As a result, errors or problems with legibility are common. While text-based information platforms like Wikipedia have benefitted enormously from crowdsourced contributions for the creation and improvement of content, the various limitations of video hinder the collaborative editing and improvement of educational videos. To address this issue, we present VidWiki, an online platform that enables students to iteratively improve the presentation quality and content of educational videos. Through the platform, users can improve the legibility of handwriting, correct errors, or translate text in videos by overlaying typeset content such as text, shapes, equations, or images. We conducted a small user study in which 13 novice users annotated and revised Khan Academy videos. Our results suggest that with only a small investment of time on the part of viewers, it may be possible to make meaningful improvements in online educational videos.
Smart &#x2014; STATCOM control strategy implementation in wind power plants (2012)

High penetration of wind energy into the grid may introduce stability and power quality problems due to the fluctuating nature of the wind and the increasing complexity of the power system. By implementing advanced functionalities in power converters, it is possible to improve the performance of the wind farm and also to provide grid support, as it is required by the grid codes. One of the main compliance difficulties that can be found in such power plants are related to reactive power compensation and to keep the harmonics content between the allowed limits, even if the power of the WPP converters is increasing. This paper deals with an advanced control strategy design of a three-level converter performing STATCOM and Active Filter functionalities. The proposed system is called Smart-STATCOM since it has the capability of self-controlling reactive power and harmonic voltages at the same time. Therefore, deciding the amount of non-active currents (fundamental, 5th and 7th harmonics) to be injected depending on the PCC voltage quality. Experimental results of the proposed control strategy are analyzed in order to validate the performance of the entire system.
Use of a Primary Epithelial Cell Screening Tool to Investigate Phage Therapy in Cystic Fibrosis (2018)

Antimicrobial-resistant microbes are an increasing threat to human health. In cystic fibrosis (CF), airway infections with Pseudomonas aeruginosa remain a key driver of lung damage. With few new antibiotics on the development horizon, alternative therapeutic approaches are needed against antimicrobial-resistant pathogens. Phage therapy, or the use of viruses that infect bacteria, is one proposed novel therapy to treat bacterial infections. However, the airways are complex microenvironments with unique characteristics that may affect the success of novel therapies. Here, three phages of P. aeruginosa (E79, F116, and one novel clinically-derived isolate, designated P5) were screened for activity against 21 P. aeruginosa strains isolated from children with CF. Of these, phage E79 showed broad antibacterial activity (91% of tested strains sensitive) and was selected for further assessment. E79 genomic DNA was extracted, sequenced and confirmed to contain no bacterial pathogenicity genes. High titre phage preparations were then purified using ion-exchange column chromatography and depleted of bacterial endotoxin. Primary airway epithelial cells derived from children with CF (n=8, age range 0.2–5.5 years, 5 males) or healthy non-CF controls (n=8, age range 2.5–4.0 years, 4 males) were then exposed to purified phage for 48 hours. Levels of inflammatory IL-1, IL-6 and IL-8 cytokine production were measured in culture supernatant by immunoassays and the extent of cellular apoptosis was measured using a ssDNA kit. Cytokine and apoptosis levels were compared between E79-stimulated and unstimulated controls, and, encouragingly, purified preparations of E79 did not stimulate any significant inflammatory cytokine responses or induce apoptosis in primary epithelial cells derived from children with or without CF. Collectively, this study demonstrates the feasibility of utilising pre-clinical in vitro culture models to screen therapeutic candidates, and the potential of E79 as a therapeutic phage candidate in CF.
Amperometric glucose sensors based on glucose oxidase immobilized in nafion (1994)

Abstract A glucose‐sensitive electrode composed of glucose oxidase (GOX) embedded in a layer of the polymer Nafion is described. Electrodes of various configurations on which the layer was cast were tested to determine their response to glucose additions to phosphate buffer and human whole serum samples. These electrodes have good response characteristics and several desirable features. Glucose sensors based on Nafion/GOX layers cast onto platinum electrodes respond to glucose additions with a rapid response time (2 to 4 seconds), have a long lifetime when stored in a phosphate buffer (55 days before termination of testing), have a reduced sensitivity to local oxygen tension, respond linearly to additions of glucose to the serum, and are not fouled by exposure to blood. The Nafion confers some permselectivity on the layer, thus providing a degree of discrimination against anioni interferents.
The effect of particle density on ultrasound-mediated transport of nanoparticles (2016)

A significant barrier to successful drug delivery is the limited penetration of nanoscale therapeutics beyond the vasculature. Building on recent in vivo findings in the context of cancer drug delivery, the current study investigates whether modification of nanoparticle drug-carriers to increase their density can be used to enhance their penetration into viscoelastic materials under ultrasound exposure. A computational model is first presented to predict the transport of identically sized nanoparticles of different densities in an ultrasonic field in the presence of an oscillating microbubble, by a combination of primary and secondary acoustic radiation forces, acoustic streaming and microstreaming. Experiments are then described in which near monodisperse (polydispersity index <0.2) nanoparticles of approximate mean diameter 200 nm and densities ranging from 1.01 g cm<sup>-3</sup> to 5.58 g cm<sup>-3</sup> were fabricated and delivered to a tissue-mimicking material in the presence or absence of a microbubble ultrasound contrast agent, at ultrasound frequencies of 0.5 MHz and 1.6 MHz and a peak negative pressure of 1 MPa. Both the theoretical and experimental results confirm that denser particles exhibit significantly greater ultrasound-mediated transport than their lower density counterparts, indicating that density is a key consideration in the design of nanoscale therapeutics.
Synthesis, biological evaluation and bioavailability prediction of novel furoxan derivatives as leishmanicidal compounds (2017)

Leishmaniasis is a neglected tropical disease, endemic in 98 countries and with more than 350 million people with risk to be sick. From 2001 to 2014, leishmanisis caused 797,849 of new cases of cutaneous and mucosal forms.&nbsp;Moreover, only in 2014, visceral leishmaniasis was detected in 3,624 american people, being Brazil responsible for 95% of this cases.&nbsp;Leishmania&nbsp;are protozoan parasites who lives in the midgut and foregut of the female sandfly of the genera Phlebotomus (Africa, Asia and Europe) and Lutzomyia (Central and South America), which is the sole vector responsible for transmitting this disease. Even though the knowledge in molecular biology and biochemistry about the parasite has increased, the first and second choice drugs for the treatment are still obsolete and with high toxicity in a long-term treatment.&nbsp;In this work, we describe the synthesis, leishmanicidal activity of&nbsp;furoxan derivatives against&nbsp;Leishmania amazonensis&nbsp;and&nbsp;Leishmania infantum&nbsp;and their bioavailability prediction.&nbsp;The compounds were synthesized from furoxan derivatives and aminoguanidine hydrochloride to give four new molecules&nbsp;in good global yields ranging from 30-60%.&nbsp;Compounds I-IV&nbsp;were characterized by analytical methods including NMR, infrared and mass spectrometry. The novel compounds were evaluated in two different species of Leishmania:&nbsp;Leishmania amazonensis&nbsp;and&nbsp;Leishmania infantum. The compounds were less cytotoxic than pentamidine. It is important to highlight the compound III, which presented a CC50&nbsp;in macrophages of 1095.52&nbsp;&micro;M, which is considerably higher than pentamidine (35.69&nbsp;&micro;M), what means that its cytotoxicity is remarkably lower than the second line drug used in leishmaniasis treatment.&nbsp; In the evaluation against promatigotes forms, all compounds have demonstrated IC50&nbsp;values superior to that of pentamidin against&nbsp;Leishmania&nbsp;amazonensis&nbsp;and a low IC50&nbsp;values compared with pentamidine against&nbsp;Leishmania infantum. Compound II presented the most promissor&nbsp;IC50 against Leishmania infantum strain with a value of 8.87&nbsp;&micro;M, while pentamidine presents an&nbsp;IC50&nbsp;value of 67.71&nbsp;&micro;M.&nbsp;For amastigote form, only two compounds with selective index superior to 15 (compounds I and III) were selected to be evaluated, and both of them presented an IC50&nbsp;higher than pentamidine. The bioavailability prediction has demonstrated that all compounds&nbsp;are in agreement with&nbsp;the Lipinski rule, and their intestinal absorption was around 70%.&nbsp; All these data allow us to conclude that the compounds were more effective against the promastigote forms of&nbsp;Leishmania infantum, which is responsible for the visceral form of leishmaniasis. In addition to their important and significant low cytotoxicity, these compounds may be a future alternative to leishmaniasis treatment.&nbsp;
Small Nuclear Ribonucleoprotein Particles Contain Glycoproteins Recognized by Rheumatic Disease-Associated Autoantibodies (1992)

Proteins from U1 and U2 small nuclear ribonucleoprotein (snRNP) particles, which are common targets of autoantibodies found in some rheumatic diseases, were analysed for the presence of glycans. A glycan detection assay revealed that the U1-specific proteins 68K and A and the U2-specific protein B" are glycosylated. However, none of the Sm proteins, which are common to all the major snRNP particles, showed a detectable level of glycosylation. With the use of specific lectins, an analysis of the particular carbohydrate(s) attached to the U1 snRNP 68K protein demonstrated the presence of at least one N-linked oligosaccharide chain. Lectin detection of galactose, glucose, mannose and N-acetylglucosamine on 68K was confirmed by chemical analysis of the carbohydrates. The glycopeptide nature of these antigens may be important for understanding the role of autoantigens in the pathogenesis of autoimmune disorder.
Surgical Fires Involving Alcohol‐Based Preparation Solution, 1991–2020 (2023)

4 Laryngoscope, 134:607-613, 2024.
Interleukin-22 promotes epithelial cell transformation and breast tumorigenesis via MAP3K8 activation (2014)

Interleukin-22 (IL-22), one of the cytokines secreted by T-helper 17 (Th17) cells, binds to a class II cytokine receptor containing an IL-22 receptor 1 (IL-22R1) and IL-10R2 and influences a variety of immune reactions. IL-22 has also been shown to modulate cell cycle and proliferation mediators such as extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), but little is known about the underlying molecular mechanisms of IL-22 in tumorigenesis. In this paper, we propose that IL-22 has a crucial role to play in controlling epithelial cell proliferation and tumorigenesis in the breast. IL-22 increased MAP3K8 phosphorylation through IL-22R1, followed by the induction of MEK-ERK, JNK-c-Jun, and STAT3 signaling pathways. Furthermore, IL-22-IL-22R1 signaling pathway activated activator protein-1 and HER2 promoter activity. In addition, Pin1 was identified as a key positive regulator for the phosphorylation-dependent MEK, c-Jun and STAT3 activity induced by IL-22. Pin1(-/-) mouse embryonic fibroblasts (MEF) exhibited significantly a decrease in IL-22-induced MEK1/2, c-Jun, and STAT3 phosphorylation compared with Pin1(+/+) MEF. In addition, a knockdown of Pin1 prevented phosphorylation induced by IL-22. The in vivo chorioallantoic membrane assay also showed that IL-22 increased tumor formation of JB6 Cl41 cells. Moreover, the knockdown of MAP3K8 and Pin1 attenuated tumorigenicity of MCF7 cells. Consistent with these observations, IL-22 levels positively correlate with MAP3K8 and Pin1 expression in human breast cancer. Overall, our findings point to a critical role for the IL-22-induced MAP3K8 signaling pathway in promoting cancer-associated inflammation in the tumor microenvironment.
Interview. Croire qu’une révision constitutionnelle produit des effets mécaniques relève de la pensée magique (2018)

Pour le politologue Patrick Le Lidec, l’introduction, il y a tout juste quinze ans, de la décentralisation dans la loi fondamentale a eu une portée limitée. En cause : la frilosité du législateur au moment de mettre en place des collectivités à statut particulier. Selon le chercheur au Centre d’études européennes de Sciences Po, il aurait sans doute mieux valu augmenter le poids des spécialistes des collectivités territoriales au sein du Conseil constitutionnel.
Coordinating Followers to Reach Better Equilibria: End-to-End Gradient Descent for Stackelberg Games (2021)

A growing body of work in game theory extends the traditional Stackelberg game to settings with one leader and multiple followers who play a Nash equilibrium. Standard approaches for computing equilibria in these games reformulate the followers' best response as constraints in the leader's optimization problem. These reformulation approaches can sometimes be effective, but often get trapped in low-quality solutions when followers' objectives are non-linear or non-quadratic. Moreover, these approaches assume a unique equilibrium or a specific equilibrium concept, e.g., optimistic or pessimistic, which is a limiting assumption in many situations. To overcome these limitations, we propose a stochastic gradient descent--based approach, where the leader's strategy is updated by differentiating through the followers' best responses. We frame the leader's optimization as a learning problem against followers' equilibrium, which allows us to decouple the followers' equilibrium constraints from the leader's problem. This approach also addresses cases with multiple equilibria and arbitrary equilibrium selection procedures by back-propagating through a sampled Nash equilibrium. To this end, this paper introduces a novel concept called equilibrium flow to formally characterize the set of equilibrium selection processes where the gradient with respect to a sampled equilibrium is an unbiased estimate of the true gradient. We evaluate our approach experimentally against existing baselines in three Stackelberg problems with multiple followers and find that in each case, our approach is able to achieve higher utility for the leader.
82. Angiotensin converting enzyme inhibitor diminished reflex tachycardia by modulating neurotransmitter release in ventrolateral medulla (1991)

Katahira, Katsutoshi; Mikaml, Hiroshi; Otsuka, Atsuhiro; Higashimori, Koichi; Moriguchi, Atsushi; Kohara, Katsuhiko; Ogihara, Toshio Author Information
MobiCom poster (2003)

article Share on MobiCom poster: mining a world of smart sensors Authors: Suman Nath Carnegie Mellon University Carnegie Mellon UniversityView Profile , Amol Deshpande U. C. Berkeley U. C. BerkeleyView Profile , Phillip B. Gibbons Intel Research Pittsburgh Intel Research PittsburghView Profile , Srinivasan Seshan Carnegie Mellon University Carnegie Mellon UniversityView Profile Authors Info & Claims ACM SIGMOBILE Mobile Computing and Communications ReviewVolume 7Issue 1January 2003 pp 34–36https://doi.org/10.1145/881978.881987Published:01 January 2003Publication History 0citation269DownloadsMetricsTotal Citations0Total Downloads269Last 12 Months0Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Middlebox Communications (midcom) Protocol Requirements (2002)

This document specifies the requirements that the Middlebox Communication (midcom) protocol must satisfy in order to meet the needs of applications wishing to influence the middlebox function. These requirements were developed with a specific focus on network address translation and firewall middleboxes.
90Yttrium-Ibritumomab-Tiuxetan as First-Line Treatment for Follicular Lymphoma: 30 Months of Follow-Up Data From an International Multicenter Phase II Clinical Trial (2012)

(90)YIT is well tolerated and achieves high response rates. Patients with increased LDH tend to relapse earlier, and individuals in remission 1 year after (90)YIT appear to have long- lasting responses.
The Possible Effect of Methylphenidate Treatment on Empathy in Children Diagnosed with Attention-Deficit/Hyperactivity Disorder, Both With and Without Comorbid Oppositional Defiant Disorder (2017)

A correlation exists between MPH-related improvement in ADHD symptoms and between more empathy in children with ADHD not comorbid with ODD.
Supplementary Figure 1 from 2-(3-{1-Carboxy-5-[(6-[<sup>18</sup>F]Fluoro-Pyridine-3-Carbonyl)-Amino]-Pentyl}-Ureido)-Pentanedioic Acid, [<sup>18</sup>F]DCFPyL, a PSMA-Based PET Imaging Agent for Prostate Cancer (2023)

&lt;p&gt;PDF file - 99K&lt;/p&gt;
Enhancement of Digital Documents (1999)

Digital document resolution conversion and enhancement is a field of image processing with two specific goals that define the field and its problems. One goal is to enable document portability by processing a document bit map in a manner that enables its displayed or printed form to be consistent in appearance when rendered by various devices. A second goal is to arrive at documents with an enhanced appearance over that attainable by directly printing the given bit map. The goals are typically achieved through spatial resolution conversion and quantization range conversion. For the image processing problems encountered, the image class and the processing setting tend to be well defined. This chapter provides a general description of the field and defines the basic terms and methods employed in resolution enhancement technology.
In Vitro and In Vivo Metabolism and Pharmacokinetics ofbis[(T-Butyl)-S-acyl-2-thioethyl]-β-L-2′,3′-dideoxy-5-fluorocytidine Monophosphate (2000)

Exposure to 10 &M L-FddCMP-bisSATE led to formation of intracellular L-FddCTP levels of 410.1(+/-) +/- 46.2 and 242.1 +/- 13.2 pmol/10(6) cells in unstimulated and PHAstimulated PBM cells, respectively; whereas, exposure of cells to the parent nucleoside, L-FddC, generated 5-10-fold less L-FddCTP. In Hep-G2 cells and EGF/HGF stimulated and unstimulated primary cultured hepatocytes, the active metabolite reached 113 +/- 29, 23.9 +/- 15.6, and 20.6 +/- 10.5 pmol/10(6) cells. Three other metabolites, L-FddCMP-monoSATE, L-FddCMP-SH, and M I, were detected intracellularly and extracellularly in all cell types examined. Intravenous administered dose of 3 mg/kg L-FddCMP-bisSATE to rhesus monkeys resulted in plasma concentration levels of 2.06 +/- 1.00 and 0.39 +/- 0.15 &M of L-FddCMP-monoSATE and L-FddC, respectively, while the prodrug was completely cleared metabolically within 15 min. Following oral administration of an equivalent dose, the absolute oral bioavailability of L-FddC derived from L-FddCMP-bisSATE administration was 65%.
In-vitro and In-vivo Studies of the Diclofenac Sodium Controlled-release Matrix Tablets (1995)

Controlled release matrix tablets for diclofenac sodium were developed in this study. Five matrix-tablet formulations were prepared by granulating two viscosity grades of HPMC (hydroxylpropylmethylcellulose) in varying ratios with water in the planetary mixer. The in-vitro dissolution tests indicate that all five matrix formulations prolong the release of diclofenac sodium. The main factors controlling drug release were the HPMC viscosity grade and the amount of HPMC used. The larger the amount of high viscosity grade HPMC used, the slower the resultant release rate of diclofenac sodium. There was no significant degradation of diclofenac sodium or change in drug release rate in any of the five formulations during a three-month period of stability testing. The sustained release ability of four formulations was further demonstrated in an in-vivo study in six healthy subjects. There were in-vitro/in-vivo correlations between Cmax, AUC0-14, and the time for 50 or 80% drug to be released.
ChemInform Abstract: Synthesis of the C1—C9 Core of Bengazole A: Harnessing the Ambident Nucleophilicity of 2‐Lithiooxazole. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.