gebhart/patrepeval huggingface dataset:
Purification, characterization and molecular modelling of two toxin‐like proteins from the Androctonus australis Hector venom (2000)

Two toxin-like proteins (AahTL1 and AahTL3) were purified from the venom of the scorpion Androctonus australis Hector (Aah). AahTL1 and AahTL3 are the first non toxic proteins cross-reacting with AahI toxins group which indicates that these proteins can be used as a model of vaccins. In order to study structure-function relationships, their complete amino-acid sequences (66 residues) were determined, by automated Edman degradation. They show more than 50% of similarity with both AahI and AahIII antimammal toxins. Three-dimensional structural models of AahTL1 and AahTL3 constructed by homology suggest that the two proteins are structurally similar to antimammal scorpion alpha-toxins specific to voltage dependent Na+ channels. The models showed also that amino-acid changes between potent Aah toxins and both AahTL1 and AahTL3 disrupt the electrostatic potential gradient at their surface preventing their interaction with the receptor, which may explain their non toxicity.
One case of swine hepatitis E virus and porcine reproductive and respiratory syndrome virus Co-infection in weaned pigs (2013)

We have detected HEV and PRRSV co-infection in one piglet. Severe pathologic changes were observed. The high mortality of weaned pigs which showed the similar clinical syptom was possibly a result of HEV and PRRSV co-infection, which has rarely been reported previously. We speculated that co-infection with PRRSV and HEV might lead to more serious problems.
Zero voltage switching characterization of 12 kV SiC N-IGBTs (2014)

This paper reports experimental zero voltage switching (ZVS) characteristics of the state-of-the-art 12 kV SiC N-IGBTs with 2 μm and 5 μm field-stop buffer layer thicknesses. Extensive results up to 7 kV and 150°C are presented for both IGBTs with and without an external snubber capacitor. The 12 kV SiC IGBTs have been found to have significantly larger magnitude of turn-off current bump in comparison to the results reported for the commercial (≤ 6.5 kV) Si IGBTs, because of deep punch-through design. The turn-off current shape is majorly influenced by slower voltage rise before the punch-through, followed by faster voltage rise after the punch-through voltage. In addition, the difference in current gain resulting from different buffer layer thicknesses has considerable effect on the overall switching behavior and energy loss of the two IGBTs. A detailed explanation of all these phenomena is presented along with the considerations for power converter design while employing the ZVS technique with these ultrahigh voltage IGBTs.
RoarNet: A Robust 3D Object Detection based on RegiOn Approximation Refinement (2019)

We present RoarNet, a new approach for 3D object detection from 2D image and 3D Lidar point clouds. Based on two stage object detection framework ([1], [2]) with PointNet [3] as our backbone network, we suggest several novel ideas to improve 3D object detection performance. The first part of our method, RoarNet_2D, estimates the 3D poses of objects from a monocular image, which approximates where to examine further, and derives multiple candidates that are geometrically feasible. This step significantly narrows down feasible 3D regions, which otherwise requires demanding processing of 3D point clouds in a huge search space. Then the second part, RoarNet_3D, takes the candidate regions and conducts in-depth inferences to conclude final poses in a recursive manner. Inspired by PointNet, RoarNet_3D processes 3D point clouds directly without any loss of data, leading to precise detection. We evaluate our method in KITTI, a 3D object detection benchmark. Our result shows that RoarNet has superior performance to state-of-the-art methods that are publicly available. Remarkably, RoarNet also outperforms state-of-the-art methods even in settings where Lidar and camera are not time synchronized, which is practically important for actual driving environment.
Freeform reflector design using integrable maps (2010)

We propose a design method for freeform reflectors based on source-target maps. The necessity for maps to fulfill the integrability condition to obtain a continuous reflector surface is discussed and demonstrated with various reflector geometries. We also review the advantages and drawbacks of reflectors with step discontinuities that do not require the integrability condition to be satisfied.
Identification of an FMR cell surface antigen associated with murine leukemia virus-infected cells (1978)

FMR antigens are found on the surface of cells infected with Friend, Moloney, and Rauscher murine leukemia viruses (MuLV). These antigens are serologically distinct from the G cell surface antigens that are found on cells infected with endogenous MuLV (AKR and Gross virus). Cell surface antigens of both virus groups are immunogenic in mice, and immunization with appropriate virus-infected cells leads to the production of cytotoxic antisera. The cytotoxic activity of FMR antisera can be absorbed by disrupted preparations of Rauscher MuLV, but not by AKR MuLV. FMR antisera precipitate the viral envelope proteins gp70, pl5(E), and p12(E) from detergent-disrupted preparations of [3H]leucine-labeled MuLV. The reaction of these antisera with p15(E) and p12(E) proteins is directed against group-specific antigens and can be absorbed with AKR MuLV; in contrast, the reaction of these antisera with gp70 is directed against type-specific antigens and is absorbed only by viruses of the FMR group. In immune precipitation assays with detergent-disrupted 125I surface-labeled cells, FMR antisera react only with type-specific antigens of the viral envelpe protein. On the basis of these findings we conclude that the FMR cell surface antigen is a determinant on the MuLV env gene product.
Efficient Digital Predistortion Using Sparse Neural Network (2020)

This paper proposes an efficient neural-network-based digital predistortion (DPD), named as envelope time-delay neural network (ETDNN) DPD. The method complies with the physical characteristics of radio-frequency (RF) power amplifiers (PAs) and uses a more compact DPD model than the conventional neural-network-based DPD. Additionally, a structured pruning technique is presented and used to reduce the computational complexity. It is shown that the resulting ETDNN obtained after applying pruning becomes so sparse that its complexity is comparable to that of conventional DPDs such as memory polynomial(MP) and generalized memory polynomial (GMP), while the degradation in performance due to the pruning is negligible. In an experiment on a 3.5-GHz GaN Doherty power amplifier (PA), our method with the proposed pruning had only one-thirtieth the computational complexity of the conventional neural-network-based DPD for the same adjacent channel leakage ratio (ACLR). Moreover, compared with memory-polynomial-based digital predistortion, our method with the proposed pruning achieved a 7-dB improvement in ACLR, despite it having lower computational complexity.
Material and Methods from A Synthetic Lethal Screen Reveals Enhanced Sensitivity to ATR Inhibitor Treatment in Mantle Cell Lymphoma with ATM Loss-of-Function (2023)

&lt;p&gt;Material and Methods&lt;/p&gt;
Permanent Removal of Condensate Banking in Tight Gas Reservoirs Using Thermochemicals (2019)

Abstract Condensate banking is a common problem in tight gas reservoirs because it diminishes the gas relative permeability and reduces the gas production rate significantly. CO2 injection is a common and very effective solution for condensate removal in tight gas reservoirs. The problem with CO2 injection is that it is a temporary solution and has to be repeated frequently in the field in addition to the supply limitations of CO2 in some areas. Also, the infrastructure required at the surface to handle CO2 injection makes it expensive to apply CO2 injection for condensate removal. In this paper, a new permanent technique is introduced to remove the condensate by using a thermochemical technique. Two chemicals will be used to generate in-situ CO2, nitrogen, steam, heat, and pressure. The reaction of the two chemicals downhole can be triggered either by the reservoir temperature, or a chemical activator. Two chemicals will start reacting and produce all the mentioned reaction products after 24 hrs. of mixing and injection. Also, the reaction can be triggered by a chemical activator and this will shorten the time of reaction. Coreflooding experiments were carried out using actual condensate samples from one of the gas fields. Tight sandstone cores of 0.9 mD permeability were used. The results of this study showed that, the thermochemical reaction products removed the condensate and reduced its viscosity due to the high temperature and the generated gases. The novelty in this paper is the creation of micro-fractures in the tight rock sample due to the in-situ generation of heat and pressure from the thermochemical reaction. These micro-fractures reduced the capillary forces that hold the condensate and enhanced its relative permeability. The creation of micro-fractures and in turn the reduction of the capillary forces can be considered as permanent condensate removal.
Heparin-binding transforming growth factor alpha-Pseudomonas exotoxin A. A heparan sulfate-modulated recombinant toxin cytotoxic to cancer cells and proliferating smooth muscle cells. (1993)

TGF alpha-PE40, a recombinant toxin in which transforming growth factor alpha (TGF alpha) is fused to a mutant form of Pseudomonas exotoxin, is selectively cytotoxic to cells bearing epidermal growth factor (EGF) receptors. Heparin binding EGF-like growth factor is a potent mitogen for smooth muscle cells capable of binding to both the EGF receptor and to immobilized heparin (Higashiyama, S., Abraham, J., Miller, J., Fiddes, J., and Klagsbrun, M. (1991) Science 251, 936-938). To study the effect of the heparin-binding domain in a chimeric toxin targeted to the EGF receptor, we fused the DNA sequence corresponding to the putative NH2-terminal heparin-binding (HB) domain of HB-EGF to chimeric toxins composed of TGF alpha and two different recombinant forms of Pseudomonas exotoxin (PE). One of these is a truncated form of PE devoid of the binding domain (TGF alpha-PE38); another is a mutant form of full-length toxin containing inactivating mutations in the binding domain and an altered carboxyl terminus (TGF alpha-PE4EKDEL). The resulting chimeric toxins HB-TGF alpha-PE38 and HB-TGF alpha-PE4EKDEL were expressed in Escherichia coli as inclusion bodies, refolded, and purified by heparin affinity chromatography. Both of the toxins were eluted from heparin at 0.8 M NaCl, in contrast to their respective TGF alpha toxins which were eluted at 0.15 M. Binding studies on A431 cells showed that the HB-TGF alpha toxins bound to the EGF receptor with an affinity similar to that of the TGF alpha toxins. However, cell killing studies on a panel of malignant cell lines showed that cytotoxicity was strongly affected by the presence of the HB domain. Cell lines expressing high numbers of EGF receptors such as A431 and KB were less sensitive to toxins containing the HB domain. Cells with low number of EGF receptors had similar responses to both types of toxins (MCF-7 and LNCaP) or were more sensitive to the toxin with the added HB domain (HEP-G2). HB-TGF alpha-PE4EKDEL was over 10-fold more cytotoxic against proliferating vascular smooth muscle cells (VSMC) than to quiescent VSMC. Moreover, HB-TGF alpha-PE4EKDEL was 6-fold more potent than TGF alpha-PE4EKDEL to proliferating VSMC. Competition studies with EGF and/or heparin showed that heparin blocks the cytotoxicity of HB-TGF toxins and the inhibitory action of heparin is stronger in cells expressing lower number of EGF receptors.(ABSTRACT TRUNCATED AT 400 WORDS)
MICROWAVE INTERFEROMETER FOR SHOCK WAVE INDUCED DISPLACEMENT MEASUREMENT (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation J. Choi, G. Youssef, S. Breugnot, V. Gupta, T. Itoh; MICROWAVE INTERFEROMETER FOR SHOCK WAVE INDUCED DISPLACEMENT MEASUREMENT. AIP Conf. Proc. 23 June 2011; 1335 (1): 1722–1726. https://doi.org/10.1063/1.3592136 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
High performance embedded system optimization using algebraic and generalized retiming techniques (2002)

Retiming, algebraic and redundancy manipulation transformations are widely used in both the high level synthesis and the compilers fields. We present a new approach on how these powerful transformations can be applied to improve the performance of embedded systems, by optimizing their latency and throughput. A simple modification is sufficient to adapt both the Leiserson-Saxe retiming algorithm and the recently introduced ERB algorithm for the new task. We introduce a new negative retiming technique and the algorithm which coordinates this technique with both algebraic and redundancy manipulation techniques for latency optimization. The effectiveness of all discussed techniques is demonstrated on a set of "real-life" examples. Latency and throughput are improved by factors of 7.06 and 2.83 respectively, often with minimal or no additional hardware overhead.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Data from Dual Inhibition of Akt/Mammalian Target of Rapamycin Pathway by <i>Nanoparticle Albumin-Bound</i>–Rapamycin and Perifosine Induces Antitumor Activity in Multiple Myeloma (2023)

Supplementary Data from Dual Inhibition of Akt/Mammalian Target of Rapamycin Pathway by &lt;i&gt;Nanoparticle Albumin-Bound&lt;/i&gt;–Rapamycin and Perifosine Induces Antitumor Activity in Multiple Myeloma
Role of Surface Temperature in the Precursor-Mediated Dissociative Chemisorption ofN2on W(100) (1988)

Molecular-beam techniques have been used to probe the dynamical origin of the surface-temperature (${T}_{s}$) dependence of the precursor-mediated dissociative chemisorption of ${\mathrm{N}}_{2}$ on W(100). Measurements of the angular and velocity distributions of scattered molecules have revealed that increasing ${T}_{s}$ primarily serves to reduce the fraction of precursor molecules that go on to dissociate, by biasing the kinetics in favor of desorption. In contrast, the trapping probability into the precursor state is found to be relatively insensitive to this parameter, accounting for \ensuremath{\lesssim}20% of the observed effects.
Synthesis and characterization of well‐defined optically active methacrylic diblock copolymers (2012)

Abstract A new, simple, and cost‐effective approach toward the development of well‐defined optically active diblock copolymers based on methacrylate monomers is described for the first time. Starting from the low‐cost optically active ( S )‐(−)‐2‐methyl‐1‐butanol, a new optically active methacrylic monomer, namely, ( S )‐(+)‐2‐methyl‐1‐butyl methacrylate [( S )‐(+)‐MBuMA], was synthesized. Reversible addition fragmentation chain transfer polymerization was then used for preparing well‐defined poly[( S )‐(+)‐MBuMA] homopolymers and water‐soluble diblock copolymers based on [( S )‐(+)‐MBuMA] and the hydrophilic and ionizable monomer 2‐(dimethyl amino)ethyl methacrylate (DMAEMA). The respective homopolymers and diblock copolymers were characterized in terms of their molecular weights, polydispersity indices, and compositions by size exclusion chromatography and 1 H NMR spectroscopy. Polarimetry measurements were used to determine the specific optical rotations of these systems. The structural and compositional characteristics of micellar nanostructures possessing an optically active core generated by p(( S )‐(+)‐MBuMA)‐ b ‐p(DMAEMA) chains characterized by predetermined molecular characteristics may be easily tuned to match biological constructs. Consequently, the aggregation behavior of the p[( S )‐(+)‐MBuMA]‐ b ‐p[DMAEMA] diblock copolymers was investigated in aqueous media by means of dynamic light scattering and atomic force microscopy, which revealed the formation of micelles in neutral and acidified aqueous solutions. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012
Identification of a discrete-time nonlinear Hammerstein-Wiener model for a selective catalytic reduction system (2011)

This paper deals with the identification of the nitrogen oxide emissions (NO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> ) from vehicles using the selective catalyst as an after treatment system for its reduction. The process is nonlinear, since the chemical reactions involved are highly depending on the operating point. The operating point is defined by the driving profile of the vehicle, which includes for example, cold and hot engine starts, highway, and urban driving. The experimental data used in this paper are based on a standard transient test developed for Euro VI testing. Real measurements of NO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> inlet concentration, injected urea, inlet temperature and exhaust flow are used as inputs to a detailed simulator. NO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> output concentration from the simulator is used as output, so there is no interference from the ammonia concentration in the NOχ output concentration due to cross-sensitivity. Experimental data are properly divided into identification and validation data sets. A Hammerstein-Wiener model is identified and it represents the dynamics very well. The best fits achieved with this model are 78.64% and 68.05% for the identification and validation data, respectively. Nonlinear static functions are selected from the knowledge and analysis of a selective catalytic reduction first principles based model. Identified linear models are able to represent the NO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> emission with a fit of 68.93% and 38.92% for the identification and validation data, respectively.
Preoperative Assessment of Bone Quality in Spine Deformity Surgery (2018)

4.
ChemInform Abstract: A Novel Application of a Pd(0)‐Catalyzed Nucleophilic Substitution Reaction to the Regio‐ and Stereoselective Synthesis of Lactam Analogues of the Epothilone Natural Products. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
AB Initio Molecular Orbital Calculation of the Vibrational Frequencies of XY 4 - n Anions (1986)

The vibrational frequencies of a series of anions (, , , , and ) have been calculated by ab initio molecular orbital theory using the 3-21G and 6-31G* basis sets. The predicted harmonic frequencies are for the most part in good agreement with the observed frequencies of these anions in molten alkali halide mixtures. At the 3-21G basis set level the average difference between the observed and predicted frequencies is 12% while at the 6-31G* basis set level the average difference is 6%. Calculations of this type may be helpful in predicting the vibrational frequencies of other anions in molten salts.
26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 (2017)

Neuro computational models represent a powerful tool for bridging&#13;\nthe gap between functions of the neural circuits and observable&#13;\nbehaviors [1]. Once the model has been built, its output is compared&#13;\nwith the observations either to validate the model itself or to propose&#13;\nnew hypotheses. This approach has led to building a multi-scale&#13;\nmodel of the sensorimotor system from muscles, proprioceptors to&#13;\nskeletal joints, spinal regulating centers and central control circuits&#13;\n[2–6].&#13;\nIn this framework, we propose a neural network architecture to&#13;\nsimulate the selection of actions performed by the motor cortex in&#13;\nresponse to a sensory input during a reward-based movement learning.&#13;\nThe network has as many input nodes as the number of different&#13;\nstimuli, each node being a combination of the sensory inputs, and as&#13;\nmany output nodes as the number of different actions that can be&#13;\nperformed, each node being a combination of the motor commands.&#13;\nThe network is fully connected, so that each stimulus concurs to the&#13;\nselection of each action and each action is selected concurrently by&#13;\nall the stimuli. The weights are updated by taking into account both&#13;\nthe expected reward and the actual reward, as suggested in [7]. By&#13;\nadopting this architecture, the percept is represented by a combination&#13;\nof sensory inputs, while the action is represented by a combination&#13;\nof motor commands. Thus, it reproduces faithfully the condition&#13;\nof experiments of motor learning when a set of sensory inputs, such&#13;\nas semantically neutral visual stimuli, are presented to the subject&#13;\nwhose response is merely a motor action, such as pushing a button.&#13;\nUnder such conditions, it then becomes possible to fit the data provided&#13;\nby the experiments with the model to both estimate the validity&#13;\nof the model and to infer the role of the parameter on behavioral&#13;\ntraits.&#13;\nThe simulations were compared to the behaviors of human subjects&#13;\nwhile learning which out of two buttons to press in response to a collection&#13;\nof visual stimuli containing edges and geometric shapes in a&#13;\nreward based setting. The results showed that the behavior of the&#13;\ncomplete system is the one expected under the hypothesis that the&#13;\nreward acts by modulating the action selection triggered by the input&#13;\nstimuli during motor learning. Moreover, differently from most literature&#13;\nmodels, the learning rate varies with the complexity of the task,&#13;\ni.e. the number of input stimuli. It can be argued that the decrease in&#13;\nlearning rate seen in humans learning large set of stimuli could be due&#13;\nto an attenuation of memory traces in real synapses over time. In our&#13;\nfuture investigations, we will work to improve the model by adding&#13;\nsuch an effect in our network.
Efficacy and safety of evogliptin in patients with type 2 diabetes and non‐alcoholic fatty liver disease: A multicentre, double‐blind, randomized, comparative trial (2021)

The peer review history for this article is available at https://publons.com/publon/10.1111/dom.14623. The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Appendix S1. Study exclusion criteria, MRI-PDFF methods and statistical analysis. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Multichannel balanced electro-optic detection for Terahertz imaging (2007)

We present THz imaging with 1D electro-optic sampling of ultrashort THz pulses by multichannel balanced detection. Using a lock-in technique, it combines the advantage of a high signal to noise ratio along with the fast acquisition time of multichannel detection. The object is probed by a line focus and the resolution can be adjusted. The performance of the system is demonstrated exemplarily by imaging two objects.