gebhart/patrepeval huggingface dataset:
Characterization of User-Perceived Quality of Service (QOS) in Mobile Devices Using Network Pairwise Comparisons (2010)

This paper presents a user-centric and application-specific QoS assessment methodology for cellular communication networks. Specifically, it uses the Analytic Hierarchy Process (AHP) to evaluate QoS as a multi-criteria decision problem that represents how well cellular networks' data services are perceived given particular sets of application classes and relative to other networks servicing in the same area. As part of the methodology, drive testing is performed to collect objective measurements associated with identified QoS criteria for data services. Once drive testing is performed and data collected, multiple networks are compared to determine the network that provides higher QoS based on users' perception of quality. The selection of the best performing network is based on the output provided by the AHP approach, which is used as unified measurement of the perceived QoS by users on different networks. In order to determine application-specific priorities, the approach presented uses three different application classes, including Emergency, Business, and Personal. For each class, the relative importance of each quality evaluation criteria is adjusted in the AHP procedure to reflect the priorities of the services expected. Through several case studies, the approach is proven successful in providing a way for analyzing user-centric QoS for application-specific scenarios.
Extracting attack knowledge using principal-subordinate consequence tagging case grammar and alerts semantic networks (2004)

The increasing use of intrusion detection systems and a relatively high false alarm rate can lead to a huge volume of alerts. This makes it very difficult for security administrators to analyze and detect network attacks. Our solution for this problem is to make the alerts machine understandable. We propose a novel way to convert the raw alerts into machine understandable uniform streams, correlate the streams, and extract the attack scenario knowledge. The modified case grammar principal-subordinate consequence tagging case grammar and the 2-atom alert semantic network are used to generate the attack scenario classes. Alert mutual information is also applied to calculate the alert semantic context window size. Based on the alert context, the attack scenario instances are extracted and the attack scenario descriptions are forwarded to the security administrator.
Unified inter- and intra-recording duration model for multiple music audio alignment (2015)

This paper presents a probabilistic audio-to-audio alignment method that focuses on the relationship among the note durations of different performances of a piece of music. A key issue in probabilistic audio alignment methods is in expressing how interrelated are the durations of notes in the underlying piece of music. Existing studies focus either on the duration of adjacent notes within a recording (intra-recording duration model), or the duration of a given note across different recordings (inter-recording duration model). This paper unifies these approaches through a simple modification to them. Furthermore, the paper extends the unified model, allowing the dynamics of the note duration to change sporadically. Experimental evaluation demonstrated that the proposed models decrease the alignment error.
Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells (2020)

Cancer-associated fibroblasts (CAFs) promote tumor growth and progression, and increase drug resistance through several mechanisms. We have investigated the effect of CAFs on the p53 response to doxorubicin in prostate cancer cells. We show that CAFs produce interleukin-6 (IL-6), and that IL-6 attenuates p53 induction and upregulation of the pro-apoptotic p53 target Bax upon treatment with doxorubicin. This is associated with increased levels of MDM2 mRNA, Mdm2 protein bound to p53, and ubiquitinated p53. IL-6 also inhibited doxorubicin-induced cell death. Inhibition of JAK or STAT3 alleviated this effect, indicating that IL-6 attenuates p53 via the JAK/STAT signaling pathway. These results suggest that CAF-derived IL-6 plays an important role in protecting cancer cells from chemotherapy and that inhibition of IL-6 could have significant therapeutic value.
Data from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma (2023)

&lt;div&gt;Abstract&lt;p&gt;Nuclear expression of the calcium-binding protein S100A4 is a biomarker of increased invasiveness in cholangiocarcinoma, a primary liver cancer with scarce treatment opportunities and dismal prognosis. In this study, we provide evidence that targeting S100A4 nuclear import by low-dose paclitaxel, a microtubule-stabilizing agent, inhibits cholangiocarcinoma invasiveness and metastatic spread. Administration of low-dose paclitaxel to established (EGI-1) and primary (CCA-TV3) cholangiocarcinoma cell lines expressing nuclear S100A4 triggered a marked reduction in nuclear expression of S100A4 without modifying its cytoplasmic levels, an effect associated with a significant decrease in cell migration and invasiveness. While low-dose paclitaxel did not affect cellular proliferation, apoptosis, or cytoskeletal integrity, it significantly reduced SUMOylation of S100A4, a critical posttranslational modification that directs its trafficking to the nucleus. This effect of low-dose paclitaxel was reproduced by ginkolic acid, a specific SUMOylation inhibitor. Downregulation of nuclear S100A4 by low-dose paclitaxel was associated with a strong reduction in RhoA and Cdc42 GTPase activity, MT1-MMP expression, and MMP-9 secretion. In an SCID mouse xenograft model, low-dose metronomic paclitaxel treatment decreased lung dissemination of EGI-1 cells without significantly affecting their local tumor growth. In the tumor mass, nuclear S100A4 expression by cholangiocarcinoma cells was significantly reduced, whereas rates of proliferation and apoptosis were unchanged. Overall, our findings highlight nuclear S100A4 as a candidate therapeutic target in cholangiocarcinoma and establish a mechanistic rationale for the use of low-dose paclitaxel in blocking metastatic progression of cholangiocarcinoma. &lt;i&gt;Cancer Res; 76(16); 4775–84. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
An evaluation of public genomic references for mapping RNA‐Seq data from Chinese hamster ovary cells (2015)

While RNA-Seq is increasingly used as the method of choice for transcriptome analysis of mammalian cell culture processes, no universal genomic reference for mapping RNA-Seq reads from CHO cells has been reported. In previous publications, de novo transcriptomes assembled using these RNA-Seq reads were subsequently used for mapping. Potential caveats with this approach include the incomplete coverage and the non-universal nature of the de novo assemblies, leading to challenges in comparing results across studies. In order to facilitate future RNA-Seq studies in CHO cells, we performed a comprehensive evaluation of four public genomic references for CHO cells hosted by the NCBI Reference Sequence Database (RefSeq), including two annotated genomes released in 2012 and 2014 and their accompanying transcriptomes. Each genome showed significantly higher mapped rates compared to its accompanying transcriptome. Furthermore, higher mapped rates in deep intra-genic regions, especially within exons, were observed for the more recent genome release (2014) compared to the older one (2012), indicating that the 2014 genome was the preeminent reference among the four. Sequential addition of human and mouse genomes increased the total mapped rate to 87.3 and 89.7%, respectively, from 73.5% using the 2014 Chinese hamster genome alone. Thus, the sequential combination of the 2014 RefSeq Chinese hamster genome, the Ensembl human genome (h38), and the Ensembl mouse genome (m38) was suggested as the most effective strategy for mapping RNA-Seq data from CHO cells.
Shrinkage Algorithms for MMSE Covariance Estimation (2010)

We address covariance estimation in the sense of minimum mean-squared error (MMSE) when the samples are Gaussian distributed. Specifically, we consider shrinkage methods which are suitable for high dimensional problems with a small number of samples (large p small n). First, we improve on the Ledoit-Wolf (LW) method by conditioning on a sufficient statistic. By the Rao-Blackwell theorem, this yields a new estimator called RBLW, whose mean-squared error dominates that of LW for Gaussian variables. Second, to further reduce the estimation error, we propose an iterative approach which approximates the clairvoyant shrinkage estimator. Convergence of this iterative method is established and a closed form expression for the limit is determined, which is referred to as the oracle approximating shrinkage (OAS) estimator. Both RBLW and OAS estimators have simple expressions and are easily implemented. Although the two methods are developed from different perspectives, their structure is identical up to specified constants. The RBLW estimator provably dominates the LW method for Gaussian samples. Numerical simulations demonstrate that the OAS approach can perform even better than RBLW, especially when n is much less than p . We also demonstrate the performance of these techniques in the context of adaptive beamforming.
Photoinduced charge separation and recombination kinetics in a dimeric iridium(I) complex with covalently bound alkyl-pyridinium acceptors (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoinduced charge separation and recombination kinetics in a dimeric iridium(I) complex with covalently bound alkyl-pyridinium acceptorsLucius S. Fox, Janet L. Marshall, Harry B. Gray, and Jay R. WinklerCite this: J. Am. Chem. Soc. 1987, 109, 22, 6901–6902Publication Date (Print):October 1, 1987Publication History Published online1 May 2002Published inissue 1 October 1987https://pubs.acs.org/doi/10.1021/ja00256a081https://doi.org/10.1021/ja00256a081research-articleACS PublicationsRequest reuse permissionsArticle Views166Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Self-similarity in the Web (2001)

Algorithmic tools for searching and mining the web are becoming increasingly sophisticated and vital. In this context, algorithms which use and exploit structural information about the web perform better than generic methods in both efficiency and reliability. We present an extensive characterization of the graph structure of the web, with a view to enabling high-performance applications that make use of this structure. In particular, we show that the web emerges as the outcome of a number of essentially independent stochastic processes that evolve at various scales. A striking consequence of this scale invariance is that the structure of the web is “fractal ” — cohesive sub-regions display the same characteristics as the web at large. An understanding of this underlying fractal nature is therefore applicable to designing data services across multiple domains and scales. We describe potential applications of this line of research to optimized algorithm design for webscale data analysis.
Self-starting passive phase conjugate mirror with Ce-doped strontium barium niobate (1987)

We report the use of Ce-doped SrxBa1−xNb2O6, x=0.60 and 0.75, as the holographic four-wave mixing medium in the construction of a self-starting passive phase conjugate mirror using internal reflection. Without correcting for Fresnel reflections, a steady-state phase conjugate reflectivity of 25% was measured with Sr0.75Ba0.25Nb2O6:Ce. The distortion correcting property of such a mirror was demonstrated using an imaging experiment.
Synthesis of (±)-benzoleukotriene B3: a novel leukotriene B4analogue (1989)

As part of a program to identify therapeutically effective leukotriene B4-antagonists, we have synthesized benzoleukotriene B3 in which the Z-6,7 double bond of LTB4 has been replaced by a phenyl group. The synthesis relies heavily on palladium(0)-mediated vinylstannane/vinyl halide coupling reactions.
In situ study of epitaxial CoSi2/Si(111) by ballistic-electron-emission microscopy (1994)

We have performed in situ ballistic-electron-emission microscopy (BEEM) and spectroscopy (BEES) at 77 K on epitaxial CoSi2/Si(111) films grown by molecular beam epitaxy. The transport in the silicide was found to be essentially ballistic. With the help of atomic-resolution scanning tunneling microscopy it has been found that the BEEM current depends significantly on the surface electronic structure. On strain-relaxed layers, hot electron scattering at individual interfacial dislocations has been observed for the first time by BEEM. Apart from the surface- and dislocation-induced contrast variations, the BEEM current is generally homogeneous.
Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition (2021)

Migraine is the sixth most prevalent disease worldwide but the mechanisms that underlie migraine chronicity are poorly understood. Cytoskeletal flexibility is fundamental to neuronal-plasticity and is dependent on dynamic microtubules. Histone-deacetylase-6 (HDAC6) decreases microtubule dynamics by deacetylating its primary substrate, α-tubulin. We use validated mouse models of migraine to show that HDAC6-inhibition is a promising migraine treatment and reveal an undiscovered cytoarchitectural basis for migraine chronicity. The human migraine trigger, nitroglycerin, produced chronic migraine-associated pain and decreased neurite growth in headache-processing regions, which were reversed by HDAC6 inhibition. Cortical spreading depression (CSD), a physiological correlate of migraine aura, also decreased cortical neurite growth, while HDAC6-inhibitor restored neuronal complexity and decreased CSD. Importantly, a calcitonin gene-related peptide receptor antagonist also restored blunted neuronal complexity induced by nitroglycerin. Our results demonstrate that disruptions in neuronal cytoarchitecture are a feature of chronic migraine, and effective migraine therapies might include agents that restore microtubule/neuronal plasticity.
Water distribution system optimization (1985)

This report describes the development of a computer program WADISO (Water Distribution Systems Optimization) which can be used to optimally size pipes in water distribution systems and select optimal pipes for cleaning and lining. The program can also be used as a steady-state simulation program to calculate flows and pressures in pipe networks. The simulation portion of the program uses the node method with sparse matrix techniques to reduce computations. The optimization portion uses a bounded enumeration technique, based on minimizing the sum of pipe installation, pipe cleaning and lining, and present worth of pumping energy costs. Only discrete commercially available pipe sizes are considered. The program can handle any typical water distribution system and includes pumps, pressure reducing valves, multiple pressure zones, and check valves. To use the optimization, the user must also specify costs as a function of pipe diameter (or use default costs in the program), minimum pressures, up to five water use loadings, a list of which pipes are to be sized, and a range of sizes to be considered. The program user's guide is included as an appendix to the report. Other appendices address how to access the program, how to obtain detailed documentation, the nature of pipe sizing, existing literature on pipe optimization, and a discussion of the relationship of pipe sizing and water distribution performance criteria. Keywords: Optimization, Pipe flow, Pipe networks, Pipe sizing, Water conveyance, Water distribution.
Mobile responder communication networks for public safety (2006)

This article proposes a paradigm shift from the prevailing public safety model of disparate, agency-owned and -operated Land Mobile Radio networks to Mobile Responder Communication Networks (MRCNs) that are created by unifying communications resources and are shared across cooperating public safety agencies to provide local, regional, or national service. MRCNs use a common IP-based core network employing service-intelligent session control to bridge networks based on LMR and commercial wireless access technologies, thus allowing the support of emerging IP-based multimedia services, high data rate access, and mission-critical tactical group voice and interoperable communications during emergency responses.
A new class of room temperature luminescent organometallic complexes: luminescence and photophysical properties of permethylscandocene chloride in fluid solution (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA new class of room temperature luminescent organometallic complexes: luminescence and photophysical properties of permethylscandocene chloride in fluid solutionBrian W. Pfennig, Mark E. Thompson, and Andrew B. BocarslyCite this: J. Am. Chem. Soc. 1989, 111, 24, 8947–8948Publication Date (Print):November 1, 1989Publication History Published online1 May 2002Published inissue 1 November 1989https://pubs.acs.org/doi/10.1021/ja00206a044https://doi.org/10.1021/ja00206a044research-articleACS PublicationsRequest reuse permissionsArticle Views278Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Market Opportunity for Multiple Antenna Technology for Next Generation Broadband Wireless Systems (2005)

The rapid growth of the Internet user base and of bandwidth-hungry applications in recent years has created a need for broadband wireless (BW) access for residential and business consumers. The only predictable trend is that data rates and QoS requirements will increase rapidly. This demand for high-speed wireless access/connectivity is becoming a market force for advanced wireless broadband technologies and networks. One of the major technology innovations to affect the future of broadband wireless industry is the use of multiple antennas and either end of the wireless link to provide unprecedented gains in capacity, link reliability and data rates. While the expected benefits associated with multiple antenna technology are high, there is a perceived significant cost (in terms of R&amp;D, implementation, hardware, inertial) associated with adoption of multiple antenna technology. This paper presents the results of a study of the evolving broadband wireless industry that aimed to analyze the barriers to adoption of multiple antenna technology in shaping future wireless systems.
An integrated lab-on-a-chip device for RNA extraction, amplification and CRISPR-Cas12a-assisted detection for COVID-19 screening in resource-limited settings (2022)

Abstract In response to the ongoing COVID-19 pandemic and disparities of vaccination coverage in low- and middle-income countries, it is vital to adopt a widespread testing and screening programme, combined with contact tracing, to monitor and effectively control the infection dispersion in areas where medical resources are limited. This work presents a lab-on-a-chip platform, namely “IFAST-CRISPR”, as an affordable, rapid and high-precision molecular diagnostic means for SARS-CoV-2 detection. The herein proposed “sample-to-answer” platform integrates RNA extraction, amplification and CRISPR-Cas-based detection with lateral flow readout in one device. The microscale dimensions of the device containing immiscible liquids, coupled with the use of silica paramagnetic beads and GuHCl, streamline sample preparation, including RNA concentration, extraction and purification, in 15 min with minimal hands-on steps. By combining RT-LAMP with CRISPR-Cas12 assays targeting the nucleoprotein (N) gene, visual identification of ≥ 470 copies mL -1 genomic SARS-CoV-2 samples was achieved in 45 min, with no cross-reactivity towards HCoV-OC43 nor H1N1. On-chip assays showed the ability to isolate and detect SARS-CoV-2 from 1,000 genome copies mL -1 of replication-deficient viral particles in 1 h. This simple, affordable and integrated platform demonstrated a visual, faster, and yet specificity and sensitivity-comparable alternative to the costly gold-standard RT-PCR assay, requiring only a simple heating source. Further investigations on multiplexing and direct interfacing of the accessible Swan-brand cigarette filter for saliva sample collection could provide a complete work flow for COVID-19 diagnostics from saliva samples suitable for low-resource settings.
Wavelet based MR 2D slice retrieval in 3D volumes (2009)

A wavelet-based, multimodal, multiscale technique is proposed for 2D slice retrieval in 3D Magnetic Resonance (MR) volumes. The use of multiscale wavelet representation facilitates robust matching of important anatomical structures at multiple resolutions. This wavelet representation gives multiscale edges and hence it is very suitable for multimodal registration and is inherently insensitive to MR field inhomogeneity. The dyadic representation allows to use dyadic step size for optimization of registration parameter space for efficient computation. We propose a fast, 2D rigid image registration scheme using mutual information (MI) as a first step for retrieval. For efficient retrieval of relevant slices a novel MI based search scheme is developed. Experiments show promising results with respect to multi-modality, accuracy, speed and robustness.