gebhart/patrepeval huggingface dataset:
Preclinical evaluation of TL-1892, a novel orally active taxane with superior in vitro and in vivo efficacy in paclitaxel and docetaxel resistant models (2008)

723 Paclitaxel and docetaxel have demonstrated parenteral, but not oral, activity in some in vitro and in vivo preclinical tumor models. However, both paclitaxel and docetaxel are not effective in resistant models such as those tumors that over express p-glycoprotein (MDR1). The comparative cytotoxic effects of TL-1892, paclitaxel and docetaxel were tested in a panel of 14 different cell lines using an MTT assay. The cell lines tested included a wide variety of human cancer cell lines: renal: melanoma: ovarian; lung; brain; colon; pancreatic and mesothelioma. TL-1892 was more potent than paclitaxel and docetaxel in all fourteen human cancer cell lines. In the taxane resistant cell lines such as TK10 (renal), OVCAR5 (ovarian), DLD-1 (colon), MSTO-211H (mesothelioma), 786-0 (renal) and A375 (melanoma), TL-1892 was at least 10 times more potent than paclitaxel. These cell lines included MDR1 resistant models and some models with other mechanisms of resistance. The in vivo activity of TL-1892 was tested in athymic nude mice in four different xenograft models. TL-1892 when dosed IV at doses of 30 mg/kg was completely curative in the MX1 human breast cancer model. TL-1892 when dosed IV at doses of 30 mg/kg on an every four day schedule for four doses was completely curative in the A375 human melanoma model. Docetaxel was not effective in this model when dosed on its optimum schedule of every 7 days for three doses. In the taxane resistant MSTO-211H human mesothelioma model, TL-1892 when dosed at 25 mg/kg on an every four day schedule for four doses showed approximately 90% tumor regression. Docetaxel was not effective in this model. In the HT29 human colon model, TL-1892 was dosed orally at a dose of 50 mg/kg and IV at a dose of 25 mg/kg on an every four day schedule for four doses. Both dosing regimens showed similar activity with greater than 90% tumor regression indicating a high bioavailability of TL-1892 when dosed orally. The toxicity of TL-1892 in rats was compared at 12 mg/kg along side docetaxel at the same dose of 12 mg/kg. The docetaxel treated rats showed high amounts of axonal degeneration while the TL-1892 treated animals showed almost no axonal degeneration indicating that TL-1892 may have advantages in the clinic with lessened neurotoxicity compared to paclitaxel and docetaxel. In summary, the oral activity of TL-1892 along with its in vivo and in vitro activity in resistant tumors and its neurotoxicity profile in rats distinguishes it from the clinically useful taxanes, paclitaxel and docetaxel.
Anti-Cancer Activity of PAK4/NAMPT Inhibitor and Programmed Cell Death Protein-1 Antibody in Kidney Cancer (2020)

This study highlights the potential of the RENCA model for evaluating immunologic responses to KPT-9274 and checkpoint inhibitor (CPI) and suggests that therapy with this combination could improve efficacy in RCC beyond what is achievable with CPI alone.
Numerical Prediction on the Characteristics of Spray-Induced Mixing and Thermal Decomposition of Urea Solution in SCR System (2004)

The spray-induced mixing characteristics and thermal decomposition of aqueous urea solution into ammonia have been studied to design optimum sizes and geometries of the mixing chamber in SCR (Selective Catalytic Reduction) system. The cold flow tests about the urea-injection nozzle were performed to clarify the parameters of spray mixing characteristics such as mean diameter and velocity of drops and spray width determined from the interactions between incoming air and injected drops. Discrete particle model in Fluent code was adopted to simulate spray-induced mixing process and the experimental results on the spray characteristics were used as input data of numerical calculations. The simulation results on the spray-induced mixing were verified by comparing the spray width extracted from the digital images with the simulated particle tracks of injected drops. The single kinetic model was adopted to predict thermal decomposition of urea solution into ammonia and solved simultaneously along with the verified spray model. The hot air generator was designed to match the flow rate and temperature of the exhaust gas of the real engines. The measured ammonia productions in the hot air generator were compared with the numerical predictions and the comparison results showed good agreements. Finally, we concluded that the design capabilities for sizing optimum mixing chamber were established.
A GLRT approach to data-aided timing acquisition in UWB radios-Part II: training sequence design (2005)

The overall system efficiency of impulse radio communications relies critically on judicious allocation of transmission resources, a portion of which should be used to ensure successful timing acquisition. In data-aided mode, optimum timing offset estimation depends not only on the mechanism used for energy capture and the acquisition algorithm employed to recover timing information, but also on the training sequence (TS) pattern from which the timing information is to be extracted. Furthermore, the transmission resources used for timing have to be balanced with that for conveying information messages in order to strike desirable tradeoffs between timing accuracy and information rate. In Part I of this paper, data-aided timing offset estimation is derived based on the maximum likelihood (ML) criterion, where only symbol-rate samples are needed for low-complexity receiver processing. To minimize the mean-square timing errors of these ML synchronizers while at the same time maximizing the average system capacity, TS design and transmit power allocation are investigated in this paper. The optimum training pattern and the number, placement, and power distribution between training and information-bearing symbols are formulated as a resource allocation optimization problem whose solution optimizes system-level performance with the minimum amount of resources consumed.
Aroma Volatile Profiles from Ripe Tomatoes are Influenced by Physiological Maturity at Harvest: An Application for Electronic Nose Technology (1998)

The effect of physiological maturity at harvest on ripe tomato ( Lycopersicon esculentum Mill.) volatile profiles was studied using ripening response time (in days) to 100 μL·L -1 exogenous ethylene treatment as a tool to separate immature-green from mature-green fruit. Electronic nose (EN) sensor array and gas chromatography (GC) analyses were used to document volatile profile changes in tomatoes that required a 1-, 3-, or 5-day ethylene treatment to reach the breaker stage. EN output analysis using multivariate discriminant and canonical analyses classified intact tomato and whole tomato homogenate samples that required 3 or 5 days of ethylene treatment as significantly different ( P &lt; 0.01) from those that required only 1 day. The GC aroma profiles from whole tomato homogenate showed that 1-day fruit had significantly higher levels ( P &lt; 0.05) of 1-penten-3-one, cis -3-hexenal, 6-methyl-5-hepten-2-one, 2-isobutylthiazole, and geranylacetone when compared to 5-day fruit. Analysis of excised tomato tissues showed that pericarp (including columnella) produced an average 219% greater concentration of the 16 aroma volatiles quantified by GC when compared to locular gel (442 and 203 μL·L -1 , respectively). EN analysis concurred with GC by showing greater average Mahalanobis distance between pericarp tissue groupings when compared to locular gel groupings (78.25 and 12.33 units, respectively). Pericarp tissue from the 5-day ethylene treatment showed significantly lower levels of 1-penten-3-one, trans -2-heptenal, 6-methyl-5-hepten-2-one, 2-isobutylthiazole, geranylacetone, and β-ionone compared to the 1- and 3-day treatments, Similarly, locular gel from the 3- and 5-day ethylene treatments had significantly lower levels of 1-penten-3-one, 2-isobutylthiazole, and 1-nitro-2-phenylethane compared to 1-day samples. cis -3-Hexenol in locular gel was the only volatile compound that showed significantly higher levels with increasing ethylene treatment. EN analysis showed greater Mahalanobis distances between 1- and 3-day ethylene samples than between 3- and 5-day ethylene samples (32.09 and 12.90, 24.14 and 6.52, 116.31 and 65.04, and 15.74 and 13.28 units, for intact tomato, whole tomato, pericarp, and locular gel homogenate, respectively).
Functional Diversity of the CD8+ T-Cell Response to Epstein-Barr Virus (EBV): Implications for the Pathogenesis of EBV-Associated Lymphoproliferative Disorders (1998)

Epstein-Barr virus (EBV)-specific CD8(+) cytotoxic T cells are thought to be critical for the control of EBV, which persists in healthy individuals as a latent infection of B cells. However, recent observations have indicated that CD8(+) T-cell responses are not uniformly cytotoxic and that CD8(+) T cells may be subdivided into type 1 and type 2 subsets that parallel the classically described Th1 and Th2 subsets of CD4(+) T cells. Using two-color flow cytometric analysis of intracellular cytokine expression at the single-cell level, we have identified two distinct but overlapping subsets of EBV-specific CD8(+) T cells, the first of which expressed high levels of interferon gamma (IFNgamma), but little or no interleukin-4 (IL-4), whereas the second subset was IFNgamma+/IL-4(+) double-positive. A significant proportion of EBV-specific CD8(+) T cells also expressed IL-13. Subsequent analysis of a panel of 27 EBV-specific CD8(+) T-cell clones showed inverse relationships between EBV-specific cytotoxicity and secretion of IL-4, IL-10, and IFNgamma, respectively. IL-10 was not secreted by the 11 most strongly cytotoxic clones, suggesting that IL-10 secretion may provide a functional definition of an EBV-specific type 2 CD8(+) T-cell subset with reduced EBV-specific cytotoxicity. Finally, we have demonstrated that EBV-specific CD8(+) T cells that express type 2 cytokines possess the ability to activate resting B cells. EBV-specific CD8(+) T cells thus have the potential to reactivate latent EBV infection in vivo and may contribute to the development of EBV-associated lymphoproliferative disorders and lymphoma.
Tailoring of cerium(IV) oxide precursors through modification of cerium(IV) isopropoxide with ß diketones (1992)

International audience
ChemInform Abstract: The Use of Palladium Chloride as a Precatalyst for the Amination of Aryl Bromides. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Differential Regulation of Three Genes Encoding Glutathione S-Transferases in Schizosaccharomyces pombe (2004)

Glutathione S-transferases (GSTs) are detoxifying enzymes that catalyze the conjugation of glutathione with a variety of reactive electrophilic compounds. Three GST genes were previously characterized in the fission yeast Schizosaccharomyces pombe. In this work, we examined the transcriptional regulation of these genes using individual GST-lacZ fusions and RT-PCR. Basal synthesis of beta-galactosidase from the GSTII-lacZ fusion was higher than from the GSTI-lacZ and GSTIII-lacZ fusion. Diethylmaleate (0.2 mM) greatly enhanced the synthesis of beta-galactosidase from the GSTII-lacZ fusion, but did not affect synthesis from the other two fusion genes. A switch to 0.3% glucose or 0.3% sucrose as sole carbon source enhanced expression from the GSTIII-lacZ fusion gene, while sodium nitroprusside (1.5 mM), tert-butylhydroquinone (0.2 mM), and L-buthionine-[S,R]-sulfoximine (0.01 mM) increased expression of the GSTII gene. The effects of these agents on GST mRNA levels were confirmed by measurements employing RT-PCR. Our results suggest that transcription of the three S. pombe GST genes is subjected to differential regulation under various stress conditions, and may be linked to their different physiological functions.
Relación entre la percepción del consumo oral de líquidos y el volumen urinario en población sana (2017)

Introduccion: el volumen urinario bajo (< 1 ml/kg/h) es el factor etiologico mas frecuente en la litiasis renal. Frecuentemente, se asume que los ninos que refieren beber mucho tienen una diuresis protectora. En este estudio analizamos el habito de consumo de liquidos en ninos sanos y su relacion con el volumen urinario.
Metodologia: se estudiaron 84 ninos, de 5 a 17 anos. Se registro la percepcion de consumo habitual de liquidos como: “poco”, “normal” o “mucho” y los tipos de bebida habitual. Se cuantifico el volumen en orina de 24 h y se relaciono con la percepcion de la ingesta de liquidos.
Resultados: la ingesta habitual de liquidos fue calificada como “poca” en el 23% de los casos, “normal” en un 56% y “mucha” en un 21%. El 39% de los ninos (33/84) presento una diuresis > 1 ml/kg/h que, por grupos, supone el 38,9% de los que refirieron una ingesta escasa, el 63% de los de consumo “normal” y el 73,7% de los que refirieron ingesta elevada. El 56% de los ninos de los grupos de ingesta “normal” y “elevada” mostraron una diuresis < 1 ml/kg/h.
Conclusiones: la mayoria de ninos mostraron una diuresis por debajo del limite recomendado, incluso entre los que refieren una ingesta “normal” o “elevada” de liquidos. Estos hallazgos hacen visible la necesidad de promover estrategias encaminadas a aumentar el consumo de agua en la poblacion.
A stochastic vector channel model-implementation and verification (1999)

The simulation of space-time receivers for wireless communication systems requires a spatial channel model which reasonably characterizes the time-variant effects of the mobile radio channel. This paper describes a space-time vector channel model with stochastic fading simulation and its effective implementation for bit-level simulations. Measurements have been analyzed in order to verify the assumptions of the channel model.
Alveolar hemorrhage in cryoglobulinemia--an indicator of poor prognosis. (2005)

Alveolitis is a rare manifestation of CG, presenting as an overwhelming systemic illness and portends a poor prognosis with a high mortality rate.
Superior Glycemic Control With a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts (2018)

We evaluated the hepatic and nonhepatic responses to glucose-responsive insulin (GRI). Eight dogs received GRI or regular human insulin (HI) in random order. A primed, continuous intravenous infusion of [3-<sup>3</sup>H]glucose began at -120 min. Basal sampling (-30 to 0 min) was followed by two study periods (150 min each), clamp period 1 (P1) and clamp period 2 (P2). At 0 min, somatostatin and GRI (36 ± 3 pmol/kg/min) or HI (1.8 pmol/kg/min) were infused intravenously; basal glucagon was replaced intraportally. Glucose was infused intravenously to clamp plasma glucose at 80 mg/dL (P1) and 240 mg/dL (P2). Whole-body insulin clearance and insulin concentrations were not different in P1 versus P2 with HI, but whole-body insulin clearance was 23% higher and arterial insulin 16% lower in P1 versus P2 with GRI. Net hepatic glucose output was similar between treatments in P1. In P2, both treatments induced net hepatic glucose uptake (HGU) (HI mean ± SEM 2.1 ± 0.5 vs. 3.3 ± 0.4 GRI mg/kg/min). Nonhepatic glucose uptake in P1 and P2, respectively, differed between treatments (2.6 ± 0.3 and 7.4 ± 0.6 mg/kg/min with HI vs. 2.0 ± 0.2 and 8.1 ± 0.8 mg/kg/min with GRI). Thus, glycemia affected GRI but not HI clearance, with resultant differential effects on HGU and nonHGU. GRI holds promise for decreasing hypoglycemia risk while enhancing glucose uptake under hyperglycemic conditions.
Design, Fabrication and Reverse Engineering of Broad Band Chirped Mirrors (2007)

We present a design-fabrication approach that enables elaborating new types of broad band chirped mirrors in short time periods. © 2007 Optical Society of America.
Evolution of solute blobs in heterogeneous porous media (2018)

We study the mixing dynamics of solute blobs in the flow through saturated heterogeneous porous media. As the solute plume is advected through a heterogeneous porous medium it suffers a series of deformations that determine its mixing with the ambient fluid through diffusion. Key questions are the relation between the spatial disorder and the mixing dynamics and the effect of the initial solute distribution. To address these questions, we formulate the advection–diffusion problem in a coordinate system that moves and rotates along streamlines of the steady flow field. The impact of the medium heterogeneity is quantified systematically within a stochastic modelling approach. For a simple shear flow, the maximum concentration of a blob decays asymptotically as $t^{-2}$ . For heterogeneous porous media, the mixing of the solute blob is determined by the random sampling of flow and deformation heterogeneity along trajectories, a mechanism different from persistent shear. We derive explicit perturbation theory expressions for stretching-enhanced solute mixing that relate the medium structure and mixing behaviour. The solution is valid for moderate heterogeneity. The random sampling of shear along trajectories leads to a $t^{-3/2}$ decay of the maximum concentration as opposed to an equivalent homogeneous medium, for which it decays as $t^{-1}$ .
Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants. (1992)

Vulnerability of specific brain regions and neuronal populations is a characteristic feature of Alzheimer disease and Down syndrome. Cholinergic neurons of the basal forebrain degenerate in both disorders. The basis for neuronal degeneration is unknown. Mouse trisomy 16 (Ts 16) is an animal model of Down syndrome. We sought an experimental system in which the survival and development of Ts 16 basal forebrain cholinergic neurons could be examined beyond the fetal period. As Ts 16 mice do not survive birth, we transplanted fetal Ts 16 and control basal forebrain into the hippocampus of young adult mice. Transplanted neurons survived and grew neurites in all grafts. Over time, we observed selective atrophy of cholinergic neurons in Ts 16 grafts. Denervation of the hippocampus produced a significant increase in the size of Ts 16 cholinergic neurons. This suggests that hippocampal-derived neurotrophic factors acted to prevent degeneration. beta/A4-amyloid-containing plaques were not seen. Ts 16 provides a model of spontaneous, genetically determined neurodegeneration that may be used to understand better the molecular pathogenesis of neuronal dysfunction in Alzheimer disease and Down syndrome.
An Organic “Donor‐Free” Dye with Enhanced Open‐Circuit Voltage in Solid‐State Sensitized Solar Cells (2014)

Organic dyes for solid-state sensitized solar cells are commonly prepared by combining an electron-withdrawing group (acceptor, A) on one side of a conjugated π-spacer and one or more electron-donating groups (donor, D) on the other side. It is shown that without an electron donor group a significantly higher open-circuit voltage is achieved, while maintaining the short-circuit current. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Intra-aortic balloon pump counterpulsation (IABP) for myocardial infarction complicated by cardiogenic shock (2011)

Available evidence suggests that IABP may have a beneficial effect on the haemodynamics, however there is no convincing randomised data to support the use of IABP in infarct related cardiogenic shock.
Beyond artificial photosynthesis: general discussion (2019)

Christoph Schnedermann opened a discussion of the paper by Burkhard König: In a broader context, it would be desirable to move towards a more holistic approach by simultaneously optimising the reaction yield and reducing the required photon input. Could you comment on the quantum yields you obs
Laser terahertz emission system to investigate hydrogen gas sensors (2005)

A laser terahertz emission system is proposed to investigate the catalytic metal/semiconductor interfaces of hydrogen sensors. Samples were fabricated by depositing a catalytic metal thin film on a semi-insulating silicon substrate. A femtosecond laser was used to radiate terahertz waves from the sample in a gas cell filled with a hydrogen and nitrogen gas mixture. The peak amplitude of the terahertz waves decreased with increasing hydrogen concentration. We also fabricated a metal-oxide-semiconductor field effect transistor hydrogen sensor, and compared its properties with the terahertz radiation properties. These results suggest that the laser terahertz emission system is a potential tool to investigate catalytic metal/semiconductor interfaces.
Characterising the loss-of-function impact of 5’ untranslated region variants in whole genome sequence data from 15,708 individuals (2019)

Abstract Upstream open reading frames (uORFs) are important tissue-specific cis -regulators of protein translation. Although isolated case reports have shown that variants that create or disrupt uORFs can cause disease, genetic sequencing approaches typically focus on protein-coding regions and ignore these variants. Here, we describe a systematic genome-wide study of variants that create and disrupt human uORFs, and explore their role in human disease using 15,708 whole genome sequences collected by the Genome Aggregation Database (gnomAD) project. We show that 14,897 variants that create new start codons upstream of the canonical coding sequence (CDS), and 2,406 variants disrupting the stop site of existing uORFs, are under strong negative selection. Furthermore, variants creating uORFs that overlap the CDS show signals of selection equivalent to coding loss-of-function variants, and uORF-perturbing variants are under strong selection when arising upstream of known disease genes and genes intolerant to loss-of-function variants. Finally, we identify specific genes where perturbation of uORFs is likely to represent an important disease mechanism, and report a novel uORF frameshift variant upstream of NF2 in families with neurofibromatosis. Our results highlight uORF-perturbing variants as an important and under-recognised functional class that can contribute to penetrant human disease, and demonstrate the power of large-scale population sequencing data to study the deleteriousness of specific classes of non-coding variants.
Automatic voice disorder recognition using acoustic amplitude modulation features (2004)

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2004.
Ka-band satellite active phased array multi-beam antenna (2005)

The paper presents a study on a Ka-band multi-beam active phased array antenna for communications satellites. We consider fully active phased array technology for beam flexibility. This antenna system currently employs four independent simultaneous spot beams in the uplink and the downlink respectively. The targeting service area is confined to most of the Asia region. For the first step of this study, a 4/spl times/4 array transmit antenna has been designed and is introduced.
Hedgehog/Gli promotes epithelial-mesenchymal transition in lung squamous cell carcinomas (2014)

Our results suggested that the Shh/Gli pathway may be critical for lung SCC recurrence, metastasis and resistance to chemotherapy. Inhibition of the Shh/Gli pathway activity/function is a potential therapeutic strategy for the treatment of lung SCC patients.