gebhart/patrepeval huggingface dataset:
EFFECT OF A NITRIC OXIDE PRE-WORKOUT SUPPLEMENT ON MUSCULAR ENDURANCE (2022)

Introduction: Multi-ingredient dietary supplements have been developed to increase nitric oxide (NO) production, with the expectation of improving resistance training performance. Many of these supplements contain ingredients and/ or ingredient amounts that have yet to be studied for their synergy or efficacy in increasing NO production and thus, resistance training performance. Purpose of the study: A randomized crossover design was used to investigate the effect of a citrulline malate (CM) based non-stimulant nitric oxide pre-workout supplement (NOPWS) blend or placebo on Young Men’s Christian Association (YMCA) bench press performance. Applied Methodology: Thirty-minutes were provided between NOPWS or placebo ingestion and YMCA bench press assessment. Pre/post heart rate was taken following each condition. Two- and one-way repeated measures ANOVAs (α = 0.05) were run to determine the effect of each condition on heart rate (HR) and the number of repetitions performed (respectively) during the bench press test. Achieved major results: There was a significant two-way interaction between the treatment and time for HR, F(1, 20) = 6.82, p = .017. Resting HR was significantly higher during the supplement session (M = 74.67, SE = 2.54 bpm) than during the placebo session (M = 69.14, SE = 2.31 bpm), F(1, 20) = 8.19, p = .010, ηp 2 = .290. No significant difference was found between conditions for number of repetitions performed. Leads: A specific CM-containing NOPWS blend had no significant effect on a standardized assessment of upper body muscular endurance. Practical implications: These findings highlight the need for consideration of the minimum eff ective dosage and assimilation timing of each respective ingredient when developing or researching pre-workout supplement blends. Originality/Value: This is the first known research to study the effectiveness of this specific blend of ingredients on resistance training performance. Thus, this study provides necessary foundational knowledge for future research in this area.
PPAR‐γ‐Mediated Regulation of Normal and Malignant B Lineage Cells (2000)

Prostaglandins of the E-series stimulate B lymphocytes by enhancing immunoglobulin-class switching and antibody production. Little is known about whether or not other prostaglandins affect B lineage cells and perhaps counterbalance the stimulatory effects of PGE2. PGD2 is a major product of cyclooxygenase in bone marrow and in macrophages, suggesting a role for this lipid product in immunological responses. PGD2 undergoes dehydration to the biologically active prostaglandin 15-deoxy-delta 12,14-PGJ2 (15d-PGJ2) that binds to the nuclear receptor known as peroxisome proliferator-activated receptor gamma (PPAR-gamma). We found that normal mouse B cells and a variety of B lymphoma cells (e.g., 70Z/3, WEHI-231, CH12, and J558) express PPAR-gamma mRNA and the 67-kDa PPAR-gamma protein. 15d-PGJ2 had a dose-dependent antiproliferative/cytotoxic effect on normal and malignant B cells, as shown by 3H-thymidine and MTT assays. Only PPAR-gamma agonists (i.e., thiazolidinediones) mimicked the effect of 15d-PGJ2 on B lineage cells, indicating that the mechanism by which 15d-PGJ2 negatively affects B lineage cells involves PPAR-gamma. The mechanism whereby PPAR-gamma agonists induced cytotoxicity is via apoptosis, as shown by Annexin V assay. PPAR-gamma agonists may serve as a counterbalance to the stimulating effects of PGE2, which promotes B-cell differentiation. The use of prostaglandins, such as 15d-PGJ2, and synthetic PPAR-gamma agonists to induce apoptosis in B lineage cells may lead to the development of therapies for fatal PGE2-resistant B lymphomas.
Modular Camera Design Study for Human Brain SPECT System (2020)

Single-photon emission computed tomography (SPECT) can be used with a wide variety of radioligands for drug discovery and pharmacokinetic studies of promising drugs for neurodegenerative diseases. We are developing a human brain SPECT system with a stationary array of detectors that will provide dynamic high-resolution, high-sensitivity imaging. We are assessing the benefits of incorporating cylindrically curved scintillation detectors, which - due primarily to significant reduction in depth of interaction uncertainty - have resolution advantages over planar detectors at the edges. We are studying the use of a cylindrically curved to planar fiber optic plate to transfer the scintillation light from the curved crystal and light guide to a planar surface for photodetection using conventional methods. Another design component being evaluated is a novel light-sensor configuration combining photomultiplier tubes (PMTs) and silicon photomultipliers (SiPMs). Simulation methods were used to predict performance of a variety of detector layouts. The purpose of the study was to balance the tradeoff between detector cost and performance, as the final imager will be comprised of 24 camera modules. We demonstrate that combining PMTs and SiPMs for electronic readout achieves a spatial resolution advantage at the edges while maintaining a lower cost than a full SiPM readout or a curved detector.
An iterative design procedure for the synthesis of generalized dual-bandpass filters (2009)

This article presents an iterative design technique to calculate the optimal position of transmission zeros in dual-bandpass filters. In the proposed design technique, the characteristic function of the filter is linearized around the displacement of the transmission zeros. A linear system is then obtained and solved in combination with a damping technique used to guarantee the convergence. Design examples which demonstrate the efficiency of the proposed method are presented and an experimental verification at 4 GHz using open-loop resonators validates the methodology. © 2009 Wiley Periodicals, Inc. Int J RF and Microwave CAE, 2009.
Compensation for process-dependent effects in the determination of localized necking limits (2016)

This work describes a new procedure to remove the differences in measured forming limits obtained from Marciniak and Nakazima tests, which are the two most frequently used testing methods to obtain necking limits for forming limit diagrams (FLD) used in formability analysis of sheet metal stamping processes. The procedure compensates for the combined effects of curvature and nonlinear strain path that occur during these tests, using measurements recorded by digital image correlation (DIC) throughout the deformation history of the point on the test specimen that eventually necks. The severity of forming is then determined by presenting the critical forming conditions in a stress diagram in order to account for the effects of through-thickness pressure that influences the onset of localized necking in the Nakazima test. These stress-based forming limits are then transformed back to the familiar strain limits (or FLD), but now representing the limits under the restriction of in-plane perfectly linear stretching and plane-stress conditions. Accounting for the effects of nonlinear strain path is particularly sensitive to the detection of the actual onset of localized necking, so this work also recommends the use of realistic methods to detect the actual onset of localized necking. The method adopted in this work is based on a new method described by Min et al. 13, [14], in which a change in the surface curvature is used to detect a geometric effect associated with the onset of localized necking. In addition to demonstrating that the standard Marciniak and Nakazima tests (punch diameter of 101.6 mm) produce essentially identical limit curves for a 980 MPa grade multi-phase high strength steel after correction for curvature, nonlinear strain path, and pressure, the method is also applied to the analysis of data from a non-standard Nakazima test with a smaller punch diameter of 50.8 mm, where the severity of these processing conditions are significantly enhanced. This additional test is further proof of the validity and comprehensive coverage of the corrections for the different processing conditions involved in measurement of forming limit curves.
Effect of far scatterer clusters in MIMO outdoor channel models (2004)

We consider the clustering structure of wireless MIMO channels, and the impact that multiple clusters have on the performance of MIMO systems. We show that multiple clusters frequently occur in urban environments. We then proceed to demonstrate that a channel with multiple scatterer clusters behaves differently than a channel with one cluster and the same rms angular spread. The differences are quantified in terms of correlation coefficients, information-theoretic capacity, and interference-suppression capabilities. This demonstrates the necessity of correctly taking into account the clustering structure.
An n-Bit Adder Realized via Coherent Optical Parallel Computing (2019)

The quantum properties of nanosystems present a new opportunity to enhance the power of classical computers, both for the parallelism of the computation and the speed of the optical operations. In this paper we present the COPAC project aiming at development of a ground-breaking nonlinear coherent spectroscopy combining optical addressing and spatially macroscopically resolved optical readout. The discrete structure of transitions between quantum levels provides a basis for implementation of logic functions even at room temperature. Exploiting the superposition of quantum states gives rise to the possibility of parallel computation by encoding different input values into transition frequencies. As an example of parallel single instruction multiple data calculation by a device developed during the COPAC project, we present a n-bit adder, showing that due to the properties of the system, the delay of this fundamental circuit can be reduced.
Fast interval-valued statistical modeling of interconnect and effective capacitance (2006)

Correlated interval representations of range uncertainty offer an attractive solution to approximating computations on statistical quantities. The key idea is to use finite intervals to approximate the essential mass of a probability density function (pdf) as it moves through numerical operators; the resulting compact interval-valued solution can be easily interpreted as a statistical distribution and efficiently sampled. This paper first describes improved interval-valued algorithms for asymptotic wave evaluation (AWE)/passive reduced-order interconnect macromodeling algorithm (PRIMA) model order reduction for tree-structured interconnect circuits with correlated resistance, inductance, and capacitance (RLC) parameter variations. By moving to a much faster interval-valued linear solver based on path-tracing ideas, and making more optimal tradeoffs between interval- and scalar-valued computations, the delay statistics roughly 10/spl times/ faster than classical Monte Carlo (MC) simulation, with accuracy to within 5% can be extracted. This improved interval analysis strategy is further applied in order to build statistical effective capacitance (C/sub eff/) models for variational interconnect, and show how to extract statistics of C/sub eff/ over 100/spl times/ faster than classical MC simulation, with errors less than 4%.
Sub-cycle electron control in the photoionization of xenon using a few-cycle laser pulse in the mid-infrared (2011)

Using few-cycle laser pulses generated by optical parametric chirped pulse amplification, sub-cycle light-wave control of electrons was achieved at a carrier wavelength of 2.1 μm. We demonstrate the sub-cycle light-wave control in the case of strong field ionization of xenon atoms. Angle-resolved spectra of electrons emitted in the photoionization process were recorded as a function of the carrier-envelope phase (CEP) using an electron imaging technique. We observed a clear CEP-dependent asymmetry in the electron momentum distribution. © IOP Publishing Ltd and Deutsche Physikalische Gesellschaft.
Heterobimetallic Calix[4]arene Complexes: Interconversion of Dimeric (Ca, Sr or Ba)/TiIV Complexes with a Monomeric K/TiIV Complex (2003)

Abstract Reaction of calix[4]arene with alkaline earth metals (Ca/Sr/Ba) in methanol followed by the addition of various titanium( IV ) sources afforded novel dimeric 1:1 alkaline earth/titanium( IV ) calix[4]arene complexes. In each complex the central core of the crystallographically imposed centrosymmetric dimer consists of a rhombus of alternating alkaline earth metals and μ 3 ‐oxo‐centres. Five terminal methanol ligands form seven‐coordinate calcium and strontium centres, while the barium centres are bridged by two additional methanol ligands, making them nine‐coordinate. Each oxo centre is the apical ligand of a square‐pyramidal titanium( IV ) centre, whose basal plane ligands are the four phenolate oxygens from a calix[4]arene in the symmetrical cone‐conformation. Deprotonation of calix[4]arene with potassium metal, followed by the addition of a titanium( IV ) source containing at least one acetylacetonate ligand, formed a mixed potassium/titanium complex based on one calix[4]arene. The potassium cation in this complex binds within the π‐basic calix[4]arene cavity, whilst titanium is octahedrally complexed in the exo ‐position, by four phenolates and one acetylacetonate. The alkaline earth titanium dimers and potassium/titanium monomers could be interconverted merely by changing the solvent, with the appropriate cations and ligands present in solution. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2003)
Novel Retinoic Acid Metabolism Blocking Agents (RAMBAs) Induce Differentiation in ATRA Resistant Cell Line: Potential New Theraputics for Acute Promyleocytic Leukemia (APL). (2005)

Abstract All trans retinoic acid (ATRA) has been used in differentiation therapy for APL and other types of cancers. However, the rapid emergence of ATRA resistance due in part to ATRA-induced acceleration of ATRA metabolism limits its use. A novel strategy to overcome the limitation associated with exogenous ATRA therapy has been developed by inhibiting the cytochrome P450-dependent ATRA-4-hydroxylase enzyme responsible for ATRA metabolism. These inhibitors are referred to as RAMBAs. Novel RAMBAs were developed which demonstrated a superior apoptosis, cell growth inhibition, in vivo anti-tumor effect in addition to the differentiation effect in breast cancer cell lines (Patel JB et al. J. Med. Chem2004,47:6716). We tested 3 RAMBAs, VN/14-1, 50-1, and 66-1 to investigate their activities against APL cell lines. RAMBAs did not confer cytotoxicity or apoptosis induction in vitro at the concentration between 0.5 to 5 μM as opposed to breast or prostate cancer cell lines. However, the differentiation effect was demonstrated by morphological and phenotypic changes using Wright-Giemsa stain and CD11b staining measured by flow cytometric analysis. VN/14-1 and VN/66-1 induced differentiation and apoptosis morphologically and phenotypically in HL60 cells. VN/14-1 and VN/50-1 showed superior differentiation in NB4 cell line compared to ATRA (70%, 69%, and 45%, respectively). Interestingly, HL60 ATRA resistant cell line was induced to undergo differentiation by VN/14-1 (0.5μM) at 55% whereas ATRA (0.5, 1, 5μM) showed less than 5% by flow cytometry analysis. VN/14-1 inhibited cell cycle at S phase whereas ATRA did not attenuate the cell cycle at the same concentration. We also tested the effect of RAMBAs on human CD34+ enriched cell colony formation. RAMBAs were added to the methylcellulose culture plates with CD34+ cells and colonies were determined after 14 days. There was no difference in the CFU-GM or BFU-E colony count between the control and the RAMBAs group. In summary, RAMBAs are promising differentiation agents in the treatment of APL, possibly through an inhibition of Cyp26A leading to increased endogenous ATRA levels. In addition, cell cycle inhibition may be a mechanism of differentiation induction in ATRA resistant cell lines. RAMBAs did not affect normal hematopoietic stem cells. We are currently testing whether RAMBAs can induce acetylation of histones in APL cell lines.
ALE meta-analysis workflows via the BrainMap database: Progress towards a probabilistic functional brain atlas (2009)

With the ever-increasing number of studies in human functional brain mapping, an abundance of data has been generated that is ready to be synthesized and modeled on a large scale. The BrainMap database archives peak coordinates from published neuroimaging studies, along with the corresponding metadata that summarize the experimental design. BrainMap was designed to facilitate quantitative meta-analysis of neuroimaging results reported in the literature and supports the use of the activation likelihood estimation (ALE) method. In this paper, we present a discussion of the potential analyses that are possible using the BrainMap database and coordinate-based ALE meta-analyses, along with some examples of how these tools can be applied to create a probabilistic atlas and ontological system of describing function-structure correspondences.
ChemInform Abstract: Chiral Atropisomeric Five‐Membered Biheteroaromatic Diphosphines: New Ligands of the Bibenzimidazole and Biindole Series. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Temporal evolution of both premotor and motor cortical tuning properties reflect changes in limb biomechanics (2015)

A prevailing theory in the cortical control of limb movement posits that premotor cortex initiates a high-level motor plan that is transformed by the primary motor cortex (MI) into a low-level motor command to be executed. This theory implies that the premotor cortex is shielded from the motor periphery, and therefore, its activity should not represent the low-level features of movement. Contrary to this theory, we show that both dorsal (PMd) and ventral premotor (PMv) cortexes exhibit population-level tuning properties that reflect the biomechanical properties of the periphery similar to those observed in M1. We recorded single-unit activity from M1, PMd, and PMv and characterized their tuning properties while six rhesus macaques performed a reaching task in the horizontal plane. Each area exhibited a bimodal distribution of preferred directions during execution consistent with the known biomechanical anisotropies of the muscles and limb segments. Moreover, these distributions varied in orientation or shape from planning to execution. A network model shows that such population dynamics are linked to a change in biomechanics of the limb as the monkey begins to move, specifically to the state-dependent properties of muscles. We suggest that, like M1, neural populations in PMd and PMv are more directly linked with the motor periphery than previously thought.
Scaling Laws for Neural Machine Translation (2021)

We present an empirical study of scaling properties of encoder-decoder Transformer models used in neural machine translation (NMT). We show that cross-entropy loss as a function of model size follows a certain scaling law. Specifically (i) We propose a formula which describes the scaling behavior of cross-entropy loss as a bivariate function of encoder and decoder size, and show that it gives accurate predictions under a variety of scaling approaches and languages; we show that the total number of parameters alone is not sufficient for such purposes. (ii) We observe different power law exponents when scaling the decoder vs scaling the encoder, and provide recommendations for optimal allocation of encoder/decoder capacity based on this observation. (iii) We also report that the scaling behavior of the model is acutely influenced by composition bias of the train/test sets, which we define as any deviation from naturally generated text (either via machine generated or human translated text). We observe that natural text on the target side enjoys scaling, which manifests as successful reduction of the cross-entropy loss. (iv) Finally, we investigate the relationship between the cross-entropy loss and the quality of the generated translations. We find two different behaviors, depending on the nature of the test data. For test sets which were originally translated from target language to source language, both loss and BLEU score improve as model size increases. In contrast, for test sets originally translated from source language to target language, the loss improves, but the BLEU score stops improving after a certain threshold. We release generated text from all models used in this study.
Mapping transcriptomic vector fields of single cells (2022)

Single-cell (sc)RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution. Fully exploiting these data, however, requires kinetic models capable of unveiling governing regulatory functions. Here, we introduce an analytical framework dynamo (https://github.com/aristoteleo/dynamo-release), which infers absolute RNA velocity, reconstructs continuous vector fields that predict cell fates, employs differential geometry to extract underlying regulations, and ultimately predicts optimal reprogramming paths and perturbation outcomes. We highlight dynamo's power to overcome fundamental limitations of conventional splicing-based RNA velocity analyses to enable accurate velocity estimations on a metabolically labeled human hematopoiesis scRNA-seq dataset. Furthermore, differential geometry analyses reveal mechanisms driving early megakaryocyte appearance and elucidate asymmetrical regulation within the PU.1-GATA1 circuit. Leveraging the least-action-path method, dynamo accurately predicts drivers of numerous hematopoietic transitions. Finally, in silico perturbations predict cell-fate diversions induced by gene perturbations. Dynamo, thus, represents an important step in advancing quantitative and predictive theories of cell-state transitions.
Specific Uptake of Tumor Necrosis Factor-α Is Involved in Growth Control of Trypanosoma brucei (1997)

Trypanosoma brucei is lysed by tumor necrosis factor-alpha (TNF-alpha) in a dose-dependent way, involving specific binding of the cytokine to a trypanosomal glycoprotein present in the flagellar pocket of the parasite. TNF-alpha-gold particles are endocytosed via coated pits and vesicles and are directed towards lysosome-like digestive organelles. The specific uptake of the cytokine by the parasite results in a developmentally regulated loss of osmoregulatory capacity. TNF-alpha specific lysis is prevented when lysis assays are performed at a temperature <26 degrees C, despite uptake of the cytokine. Inhibition of lysis is also observed when a lysosomotropic agent is added during the first 2 h of incubation. Both monomorphic and pleomorphic trypanosomes are lysed but only when isolated during the peak of parasitaemia. Lysis is not observed with early infection stage parasites or procyclic (insect-specific) forms. Anti-TNF-alpha treatment of T. brucei-infected mice reveals a dramatic increase in parasitaemia in the blood circulation, the spleen, the lymph nodes, and the peritoneal cavity. These data suggest that in the mammalian host, TNF-alpha is involved in the growth control of T. brucei.