gebhart/patrepeval huggingface dataset:
A One-Step Synthesis of 2,3-Dihydro-4H-pyran-4-ones from 3-Ethoxy α,β-Unsaturated Lactones (2005)

[reaction: see text] Addition of diverse nucleophiles to the unsaturated lactone 2 that results from hetero Diels-Alder reaction of Brassard's diene 1 with aldehydes leads to an efficient and general approach to the synthesis of 2,3-dihydro-4H-pyran-4-ones 3.
Age and Morphine Analgesia in Cancer Patients with Postoperative Pain (1981)

Analgesic Studies Section, Memorial Sloan-Kettering Cancer Center, and Department of Pharmacology, Cornell University Medical College, New York, New York
Development and Evaluation of Carrier Glass Substrate for Fan-Out WLP/PLP Process (2017)

The effect of glass type used as fan-out carrier substrate on the reliability of the electrical devices were investigated. Glasses with thermal expansion coefficient of around 6~8 ppm/K with and without alkali ions involved in the glass were tested. With using non-alkali type glass as the carrier material, it was confirmed that the lifetime of the test vehicles were longer than that heated with conventional soda-lime silicate glass by the evaluation under highly accelerated steam and temperature condition.
Tubal and ovarian pathways to pelvic epithelial cancer: a pathological perspective (2009)

Prolongation of ovarian epithelial cancer survival depends on early detection or improved responses to chemotherapy. Gains in either have been modest at best. Understanding the diverse pathogenesis of this disease is critical to early intervention or prevention. This review addresses six important variables, including (i) cell of origin, (ii) site of origin, (iii) initial genotoxic events, (iv) risks imposed by hereditary and other promoting conditions, (v) subsequent factors that promote different patterns of metastatic spread, and (vi) prospects for intervention. This review proposes two distinct pathways to pelvic epithelial cancer. The first initiates in ovarian surface epithelium (OSE), Mullerian inclusions or endometriosis in the ovary. The second arises from the endosalpinx and encompasses a subset of serous carcinomas. The serous carcinogenic sequence in the distal fallopian tube is described and contrasted with lower grade serous tumors based on tumour location, earliest genetic change and ability (or lack of) to undergo terminal (ciliated) differentiation. Ultimately, a clear understanding of tumour origin and the mechanism(s) leading to the earliest phases of the serous and endometrioid carcinogenic sequences may hold the greatest promise for designing prevention strategies and/or developing new therapies.
NEP-A and NEP-B both contribute to nuclear pore formation in Xenopus eggs and oocytes (2008)

In vertebrates, the nuclear envelope (NE) assembles and disassembles during mitosis. As the NE is a complex structure consisting of inner and outer membranes, nuclear pore complexes (NPCs) and the nuclear lamina, NE assembly must be a controlled and systematic process. In Xenopus egg extracts, NE assembly is mediated by two distinct membrane vesicle populations, termed NEP-A and NEP-B. Here, we re-investigate how these two membrane populations contribute to NPC assembly. In growing stage III Xenopus oocytes, NPC assembly intermediates are frequently observed. High concentrations of NPC assembly intermediates always correlate with fusion of vesicles into preformed membranes. In Xenopus egg extracts, two integral membrane proteins essential for NPC assembly, POM121 and NDC1, are exclusively associated with NEP-B membranes. By contrast, a third integral membrane protein associated with the NPCs, gp210, associates only with NEP-A membranes. During NE assembly, fusion between NEP-A and NEP-B led to the formation of fusion junctions at which >65% of assembling NPCs were located. To investigate how each membrane type contributes to NPC assembly, we preferentially limited NEP-A in NE assembly assays. We found that, by limiting the NEP-A contribution to the NE, partially formed NPCs were assembled in which protein components of the nucleoplasmic face were depleted or absent. Our data suggest that fusion between NEP-A and NEP-B membranes is essential for NPC assembly and that, in contrast to previous reports, both membranes contribute to NPC assembly.
ChemInform Abstract: P(CH3NCH2CH2)3N: A Nonionic Superbase for Efficient Dehydrohalogenation. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Test-Point Insertion Efficiency Analysis for LBIST in High-Assurance Applications (2017)

Test points are inserted into integrated circuits to increase fault coverage especially in logic built-in self-test schemes. Commercial tools have been developed over the past decade to insert test points in circuits under test, but they are often inefficient and incur unacceptably large area overhead. Our analysis shows that many test points have little or no impact on test coverage. Furthermore, depending on where test points are inserted, they can create a significant area overhead unnecessarily. Therefore, we propose a novel timing-aware framework to evaluate test points' impact on a design, rank them based on their efficiency, and obtain an optimal configuration of the most efficient test points accurately and rapidly. Specifically, the proposed framework considers not only individual test coverage improvement but also area penalty, path timing, and region in which each test point is inserted. Within this framework, we have two metrics, namely, efficient test point insertion (ETPI) and test point removal estimation (TPRE). The ETPI metric is developed to remove the most inefficient test points inserted in the circuit by commercial tools, thereby minimizing area penalty with very limited test coverage loss. The TPRE metric is introduced to estimate area overhead and test coverage for designs with different percentages (number) of test points removed without the actual insertion of test points and without the need for lengthy circuit simulation, thereby quickly selecting the most effective test point removal scheme and saving significant amount of processing time especially for large circuits. Experimental results, collected by applying the metrics to NXP Semiconductors circuits and academic benchmark circuits, indicate that ETPI can reduce area overhead by up to 95% with test coverage loss as low as 0.57%. In addition, results by applying the TPRE metric indicate that the difference between estimation and actual simulation/synthesis results for area overhead is less than 0.20% for most cases, and the difference between them for test coverage is less than 1% for most cases.
Platycodin D Reverses Pathological Cardiac Hypertrophy and Fibrosis in Spontaneously Hypertensive Rats (2018)

Platycodin D (PD) is the main active saponin isolated from Platycodon grandiflorum (PG) and is reported to exhibit anticancer, anti-angiogenic, anti-inflammation and anti-obesity biological effects. The current study aims to evaluate the therapeutic efficacy of PD in cardiac fibrosis and for hypertrophy in spontaneous hypertension rats (SHRs) and to verify inhibition of the signaling pathway. Significant increases in the cardiac functional indices of left ventricular internal diameter end diastole (LVIDd) and left ventricular internal diameter end systole (LVIDs); the eccentric hypertrophy marker p-MEK5; concentric hypertrophy markers, such as CaMKII[Formula: see text] and calcineurin; and expression levels of NFATc3, p-GATA4 and BNP were observed in spontaneously hypertensive groups. PD treatment reversed these increases in SHRs. In addition, an increase in the fibrosis markers FGF2, uPA, MMP2, MMP9, TGF[Formula: see text]-1 and CTGF during cardiac hypertrophy was detected by western blotting analyses. These results demonstrated that PD treatment considerably attenuates cardiac fibrosis. Histopathological examination revealed that PD treatment remarkably reduced collagen accumulation in contrast to spontaneously hypertensive groups. This study clearly suggests that PD provides myocardial protection by alleviating two damaging responses to hypertension, fibrosis and hypertrophy, in the heart.
Abstract 3127: Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target. (2013)

Abstract The NKX2-1 transcription factor, a regulator of normal lung development, is the most significantly amplified gene in human lung adenocarcinoma. To better understand how genomic alterations of NKX2-1 drive tumorigenesis, we generated an expression signature associated with NKX2-1 amplification in human lung adenocarcinoma, and analyzed DNA binding sites of NKX2-1 by genome-wide chromatin immunoprecipitation (ChIP-seq) from three NKX2-1-amplified human lung adenocarcinoma cell lines. Integration of these expression and cistromic analyses suggested that aberrant over-expression of NKX2-1 primarily activates the expression of transcriptional target genes whose expression is not trans-activated by NKX2-1 at physiological expression levels, and identified LMO3, itself encoding a transcription regulator, as a candidate direct transcriptional target of NKX2-1. NKX2-1 amplification is most significantly associated with over-expression of the LMO3 gene, a member of the LMO family of oncogenes that are translocated in T-ALL, the same disorder in which NKX2-1 translocation has been observed. We further show that NKX2-1 interacts physically with the LMO3 locus, and activates its expression. RNA interference analysis of NKX2-1-amplified cells compared to non-amplified cells demonstrated that LMO3 mediates cell proliferation downstream of NKX2-1. Further cistromic analyses found that consensus binding motifs including a nuclear hormone receptor signature and a Forkhead box motif, indicating that NKX2-1 might cooperate with Forkhead box FOXA1 and nuclear hormones to regulate gene expression. Genome-wide analysis of FOXA1 occupancy by ChIP-seq in the NCI-H3122 cell line revealed that FOXA1 binds not only to the LMO3 locus upstream of NKX2-1 binding site but also to many NKX2-1 occupied regions (47% of total NKX2-1-bound sites). Our findings provide new insight into the transcriptional regulatory network of NKX2-1 and suggest that LMO3 is a transducer of lineage specific cell survival of NKX2-1-amplified lung adenocarcinomas. Citation Format: Hideo Watanabe, Joshua M. Francis, Michele S. Woo, Banafsheh Etemad, Wenchu Lin, Daniel F. Fries, Shouyong Peng, Eric L. Snyder, Purushothama Rao Tata, Anna C. Schinzel, Jeonghee Cho, Peter S. Hammerman, Roel G. Verhaak, William C. Hahn, Jayaraj Rajagopal, Tyler Jacks, Matthew Meyerson. Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3127. doi:10.1158/1538-7445.AM2013-3127
Use of a simple cavity geometry for low and high repetition rate modelocked Ti:sapphire lasers (2004)

We demonstrate a general procedure for varying the repetition rate of a modelocked Ti:sapphire laser using an asymmetric focusing geometry. Using this procedure, we have made an extended length cavity with a repetition rate of 45 MHz, and a reduced length cavity with a repetition rate of 275 MHz, each of which generates sub-20 fs pulses. This procedure allows the repetition rate of the laser to be more precisely tailored for a variety of applications without compromise in performance.
Conformation of the helical nucleocapsids of paramyxoviruses and vesicular stomatitis virus: reversible coiling and uncoiling induced by changes in salt concentration. (1980)

The conformations of the helical nucleocapsids of the paramyxoviruses Sendai virus and simian virus 5, and of a rhabdovirus, vesicular stomatitis virus, have been found to vary extensively with changes in salt concentration. In 10 mM sodium phosphate buffer at pH 7.2, the nucleocapsids are loosely coiled or almost completely extended; with increasing concentrations of NaCl they become more tightly coiled and less flexible. Under isotonic conditions (150 mM) the Sendai virus nucleocapsid is moderately tightly coiled but still curved and apparently flexible, whereas at 400 mM or higher it is very tightly coiled, with the appearance of a rigid rod. These salt-dependent changes in conformation were also found with nucleocapsids composed of proteolytically cleaved protein subunits. Because of the effect of salt concentration, and the fact that it may change during the preparation of negatively stained samples of electron microscopy, it was necessary to fix that nucleocapsids before negative staining to preserve their original conformation. The striking changes in nucleocapsid conformation in response to the ionic milieu indicate the plasticity of its helical structure and suggest that changes in the microenvironment of the nucleocapsid could influence its conformation during viral RNA transcription and replication or during virus assembly by budding, processes in which changes in the coiling of the nucleocapsid or its flexibility could be important.
Human immunodeficiency virus type 1 infection of neural xenografts. (1992)

Human immunodeficiency virus type 1 (HIV-1) infection is highly specific for its human host. To study HIV-1 infection of the human nervous system, we have established a small animal model in which second-trimester (11 to 17.5 weeks) human fetal brain or neural retina is transplanted to the anterior chamber of the eye of immunosuppressed adult rats. The human xenografts vascularized, formed a blood-brain barrier, and differentiated, forming neurons and glia. The xenografts were infected with cell-free HIV-1 or with HIV-1-infected human monocytes. Analysis by polymerase chain reaction revealed HIV-1 sequences in DNA from xenograft tissue exposed to HIV-1 virions, and in situ hybridization demonstrated HIV-1 mRNA localized in macrophages and multinucleated giant cells. Pathological damage was observed only in neural xenografts containing HIV-1-infected human monocytes, supporting the hypothesis that these cells mediate neurotoxicity. This small animal model allows the study of direct and indirect effects of HIV-1 infection on developing human fetal neural tissues, and it should prove useful in evaluating antiviral therapies, which must ultimately target HIV-1 infection of the brain.
Partially Calcined Gismondine Type Silicoaluminophosphate SAPO-43:  Isopropylamine Elimination and Separation of Carbon Dioxide, Hydrogen Sulfide, and Water (2003)

Selective removal of carbon dioxide and hydrogen sulfide from other gases is usually difficult to achieve because most of the available sorbents will also adsorb other unwanted molecules. SAPO-43 is a microporous sorbent with appropriate dimensions and characteristics for these types of separations, but previous studies have shown that, because of low thermal stability, it is not suitable. This study discusses a procedure developed to partially remove the organic moiety used for synthesis of SAPO-43 while preserving the framework. The thermal process to remove the template (isopropylamine) results in decomposition of the species, which is believed to be a result of a Hofmann elimination process. Afterward, the partially calcined silicoaluminophosphate can be used as a selective adsorbent to separate molecules like CO2, H2O, and H2S while excluding molecules such as N2, CH4, and O2. In general, it was found that SAPO-43 has adsorption capacities of 1.1, 4.93, and 2.52 mmol/g for CO2, H2O, and H2S, respectively, at 25 °C and atmospheric conditions.
Subcellular Localization and Biological Actions of Activated RSK1 Are Determined by Its Interactions with Subunits of Cyclic AMP-Dependent Protein Kinase (2006)

Cyclic AMP (cAMP)-dependent protein kinase (PKA) and ribosomal S6 kinase 1 (RSK1) share several cellular proteins as substrates. However, to date no other similarities between the two kinases or interactions between them have been reported. Here, we describe novel interactions between subunits of PKA and RSK1 that are dependent upon the activation state of RSK1 and determine its subcellular distribution and biological actions. Inactive RSK1 interacts with the type I regulatory subunit (RI) of PKA. Conversely, active RSK1 interacts with the catalytic subunit of PKA (PKAc). Binding of RSK1 to RI decreases the interactions between RI and PKAc, while the binding of active RSK1 to PKAc increases interactions between PKAc and RI and decreases the ability of cAMP to stimulate PKA. The RSK1/PKA subunit interactions ensure the colocalization of RSK1 with A-kinase PKA anchoring proteins (AKAPs). Disruption of the interactions between PKA and AKAPs decreases the nuclear accumulation of active RSK1 and, thus, increases its cytosolic content. This subcellular redistribution of active RSK1 is manifested by increased phosphorylation of its cytosolic substrates tuberous sclerosis complex 2 and BAD by epidermal growth factor along with decreased cellular apoptosis.
An Intelligent Physical Layer For Cognitive Radio Networks (2008)

In this paper, we present an intelligent physical layer for cognitive mesh networks. It is well recognized that wireless mesh networks suffer from the inherent property of per hop delay attributed to store and forward routing and channel contention. We show that an intelligent physical layer coupled
Supplementary Figures from Opposing Effects of Androgen Deprivation and Targeted Therapy on Prostate Cancer Prevention (2023)

&lt;p&gt;Supplementary Figures PDF file - 5047K, supplementary figures for opposing effects of androgen deprivation and targeted therapy on prostate cancer prevention&lt;/p&gt;
Efficient Partial Recovery of Flexible-Rate Transceivers with SDN-based Asymmetric Multipath Routing of IP Traffic (2016)

New optical elasticity features of bandwidth-variable transponders together with intelligent recovery capabilities in optical transport networks might enable partial recovery of an optical wavelength capacity. However, current ECMP-based mechanisms are unable to utilize partially recovered links efficiently. This paper presents software defined network (SDN)-based asymmetric multipath routing, enabling the usage of these links. By introducing adapted fine-granular load balancing and segment routing mechanisms, this new concept aims at making the most of the partially recovered capacity and thus reducing the required standby capacity for restoration. We outline the investigated SDN control architecture and introduce the practical design and implementation approach.
SAR500 - A high-precision high-stability butterfly gyroscope with north seeking capability (2010)

This paper describes a novel high-precision, low-noise, high-stability, calibrated and compensated digital oscillatory gyroscope with SPI interface, housed in custom-made ceramic packages. The device is factory-calibrated and compensated for temperature effects to provide high-accuracy digital output over a broad temperature range. Optimized tuning of the excitation and detection frequencies, as well as optimized mechanical and electrical balancing result in low sensitivity to shock and vibrations. By utilizing a unique sealed cavity technology, the vibrating elements of the gyroscope are contained within the low-pressure hermetic environment needed for high Q factors. Further on, improved stability of the device is achieved by full design symmetry, high thermal efficiency and choice of crystalline materials in the entire structure.
Odorant Receptor 7D4 Activation Dynamics (2018)

Deciphering how an odorant activates an odorant receptor (OR) and how changes in specific OR residues affect its responsiveness are central to understanding our sense of smell. A joint approach combining site-directed mutagenesis and functional assays with computational modeling has been used to explore the signaling mechanics of OR7D4. In this OR, a genetic polymorphism affects our perception of androstenone. Molecular simulations totaling 0.12 ms predicted that, similarly to observations for other G-protein-coupled receptors with known experimental structures, an activation pathway connects the ligand and the G-protein binding site. The 3D model activation mechanism correlates with in vitro data and notably predicts that the OR7D4 WM variant is not activated. Upon activation, an OR-specific sequence motif is the convergence point of the mechanism. Our study suggests that robust homology modeling can serve as a powerful tool to capture OR dynamics related to smell perception.
Catalyzing Learner Engagement using Cutting-Edge Classroom Response Systems in Higher Education (2013)

In this chapter, we introduce a new technology for facilitating and measuring learner engagement. The system creates a learning experience for students based on frequent feedback, which is critical to learning. We open by problematizing traditional approaches to learner engagement that do not maximize the potential of feedback and offer a research-based solution in a new classroom response system (CRS) two of the authors developed at Harvard University – Learning Catalytics. The chapter includes an overview of cognitive science principles linked to student learning and how those principles are tied to Learning Catalytics. We then provide an overview of the limitations of existing CRSs and describe how Learning Catalytics addresses those limitations. Finally, we describe how we used Learning Catalytics to facilitate and measure learner engagement in novel ways, through a pilot implementation in an undergraduate physics classroom at Harvard University. This pilot was guided by two questions: How can we use Learning Catalytics to help students engage with subject matter in ways that will help them learn? And how can we measure student engagement in new ways using the analytics built into the system? The objective of this chapter is to introduce Learning Catalytics as a new instructional tool and respond to these questions.
Two Case Studies on Data Sensitivity of Wireless Sensor Network Algorithms and our Proposal on Scalable, Synthetic Data Generation (2006)

Sensor network research is still in its infancy. There is a large volume of exploratory research. From lack of experimental data and sophisticated models derived from such data, many sensor network publications continue to use data generated from simple models in their algorithm evaluation. It is commonly agreed that data processing algorithms in sensor networks are sensitive to input data. However, no previous efforts have been devoted to quantitatively characterize the range of the algorithm performance when evaluated using different data input. In this paper, we made the first attempt to quantify the algorithm's sensitivity to data. Our evaluation results demonstrated that different data input could change the algorithm performance by as much as an order of magnitude or even change the relative performance order of two alternative algorithms. This pointed out the need to evaluate sensor network systems with data representing a wide range of real-world scenarios. For each algorithm in our case study, we identified a small set of data characteristics essential to the algorithm's performance. This defined a unique feature of our synthetic data generation framework and made both synthetic data generation and evaluation scalable. To support systematic algorithm evaluation and robust algorithm design and deployment, our synthetic data generation toolbox can generate 1. irregular topology data based on empirical models which will maintain important features of the experimental data; and 2. data corresponding to a wide range of parameter values.