gebhart/patrepeval huggingface dataset:
Analysis of Azimuthal Thermoacoustic Modes in Annular Gas Turbine Combustion Chambers (2014)

Modern gas turbine combustors operating in lean-premixed mode are prone to thermoacoustic instabilities. In annular combustion chambers, usually azimuthal acoustic modes are the critical ones interacting with the flame. In case of constructive interference, high amplitude oscillations might result. In this paper, the azimuthal acoustic field of a full-scale engine is investigated in detail. The analyses are based on measurements in a full-scale gas turbine, analytical models to derive the system dynamics, as well as simulations performed with an in-house 3d nonlinear network model. It is shown that the network model is able to reproduce the behaviour observed in the engine. Spectra, linear growth rates, as well as the statistics of the system’s dynamics can be predicted. A previously introduced algorithm is used to extract linear growth rates from engine and model time domain data. The method’s accuracy is confirmed by comparison of the routine’s results to analytically determined growth rates from the network model. The network model is also used to derive a burner staging configuration resulting in the decrease of linear growth rate and thus an increase of engine operation regime; model predictions are verified by full-scale engine measurements. A thorough investigation of the azimuthal modes statistics is performed. Additionally, the network model is used to show that an unfavorable flame temperature distribution with an amplitude of merely 1% of the mean flame temperature can change the azimuthal mode from dominantly rotating to dominantly standing. This is predicted by the network model that only takes into account flame fluctuations in axial direction.
SoC-C (2008)

The architectures of system-on-chip (SoC) platforms found in high-end consumer devices are getting more and more complex as designers strive to deliver increasingly compute-intensive applications on near-constant energy budgets. Workloads running on these platforms require the exploitation of heterogeneous parallelism and increasingly irregular memory hierarchies. The conventional approach to programming such hardware is very lowlevel but this yields software which is intimately and inseparably tied to the details of the platform it was originally designed for, limiting the software's portability, and, ultimately, the architectural choices available to designers of future platform generations. The key insight of this paper is that many of the problems experienced in mapping applications onto SoC platforms come not from deciding how to map a program onto the hardware but from the need to restructure the program and the number of interdependencies introduced in the process of implementing those decisions. We tackle this complexity with a set of language extensions which allows the programmer to introduce pipeline parallelism into sequential programs, manage distributed memories, and express the desired mapping of tasks to resources. The compiler takes care of the complex, error-prone details required to implement that mapping. We demonstrate the effectiveness of SoC-C and its compiler with a "software defined radio" example (the PHY layer of a Digital Video Broadcast receiver) achieving a 3.4x speedup on 4 cores.
Smart CMOS Sensors with Integrated Magnetic Concentrators (2006)

The combination of integrated magnetic concentrators (IMC) and modern CMOS Hall sensor technology extends the frontiers of magnetic sensing to new dimensions. Single-axis sensors are turned into multi-axis sensors while signal quality and resolution are enhanced by up to one order of magnitude. Integrated Magnetic Concentrators have a deep impact on sensor system design. On one hand, the material properties of the added magnetic layer and the tolerances arising from its deposition and structuring have to be taken into account. On the other hand multi-axis sensors offer the possibility to work with ratios of magnetic field components rather than with a single field component. This results in ageing and drift effects of sensor and magnet being virtually eliminated
Faculty Opinions recommendation of Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells. (2005)

Cdc42 is a small GTPase involved in the regulation of the cytoskeleton and cell polarity. To test whether Cdc42 has an essential role in the formation of filopodia or directed cell migration, we generated Cdc42-deficient fibroblastoid cells by conditional gene inactivation. We report here that loss of Cdc42 did not affect filopodium or lamellipodium formation and had no significant influence on the speed of directed migration nor on mitosis. Cdc42-deficient cells displayed a more elongated cell shape and had a reduced area. Furthermore, directionality during migration and reorientation of the Golgi apparatus into the direction of migration was decreased. However, expression of dominant negative Cdc42 in Cdc42-null cells resulted in strongly reduced directed migration, severely reduced single cell directionality, and complete loss of Golgi polarization and of directionality of protrusion formation toward the wound, as well as membrane blebbing. Thus, our data show that besides Cdc42 additional GTPases of the Rho-family, which share GEFs with Cdc42, are involved in the establishment and maintenance of cell polarity during directed migration.
Figure S2 from α<sub>v</sub>β<sub>3</sub> Integrin Mediates Radioresistance of Prostate Cancer Cells through Regulation of Survivin (2023)

&lt;p&gt;alphaV and beta1 in PC-3 beta3 shRNA&lt;/p&gt;
Reactions of Coordinated Ligands. XI. The Formation and Properties of a Tridentate Macrocyclic Ligand Derived from o-Aminobenzaldehyde (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of Coordinated Ligands. XI. The Formation and Properties of a Tridentate Macrocyclic Ligand Derived from o-AminobenzaldehydeGordon A. Melson and Daryle H. BuschCite this: J. Am. Chem. Soc. 1965, 87, 8, 1706–1710Publication Date (Print):April 1, 1965Publication History Published online1 May 2002Published inissue 1 April 1965https://pubs.acs.org/doi/10.1021/ja01086a015https://doi.org/10.1021/ja01086a015research-articleACS PublicationsRequest reuse permissionsArticle Views383Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Analyzing the effects of engineering cardiomyocyte shape: quantitative phase imaging reveals differences in morphology and function (Conference Presentation) (2019)

Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) have promise for elucidating basic biological processes, drug testing, and regenerative medicine, yet are known to be heterogenous and immature. Methods to analyze cardiomyocytes are typically destructive or require labeling that alters the cells’ performance. Thus, we have developed a non-invasive image-based method for analyzing and classifying cardiomyocytes based on their morphology and contractile properties, and applied this method to analyze the effects of controlling cell shape. We optimized a diffraction phase microscope (DPM) to yield low noise optical thickness measurements at over 100 frames per second. We extracted contraction and relaxation motion cycles of single hiPSC-CMs and analyzed beat frequency and regularity. DPM also enabled comparisons of morphological characteristics by measuring the optical thickness of the cells. We compared populations of hiPSC-CMs with controlled (patterned) and uncontrolled (unpatterned) shape and we observed the following: 1) patterning effectively controls the shape of the cells, while cells with the desired mature-like shape rarely appear in the unpatterned population, 2) patterned cells are more likely to beat with consistent and lower beat frequency compared to unpatterned cells, and 3) the patterns tend to select for larger (more mature-like) cells. Finally, we identified a cutoff point under which cells of a certain dry mass do not adhere to the patterns. These results indicate that controlling the shape of hiPSC-CMs improves their characteristics, which can be analyzed using DPM, and has the potential to yield more consistent research results and homogenous populations of cells for clinical applications.
(Z)-Stereoselective Synthesis of Mono- and Bis-heterocyclic Benzimidazol-2-ones via Cascade Processes Coupled with the Ugi Multicomponent Reaction (2015)

Several novel cascade reactions are herein reported that enable access to a variety of unique mono- and bis-heterocyclic scaffolds. The sequence of cascade events are mediated through acid treatment of an Ugi adduct that affords 1,5-benzodiazepines which subsequently undergo an elegant rearrangement to deliver (E)-benzimidazolones, which through acid-promoted tautomerization convert to their corresponding (Z)-isomers. Moreover, a variety of heterocycles tethered to (Z)-benzimidazole-2-ones are also accessible through similar domino-like processes, demonstrating a general strategy to access significantly new scaffold diversity, each containing four points of potential diversification. Final structures of five scaffolds have been definitively proven by X-ray crystallography.
Sustaining dry surfaces under (2015)

Rough surfaces immersed under water remain practically dry if the liquid-solid contact is on roughness peaks, while the roughness valleys are filled with gas. Mechanisms that prevent water from invading the valleys are well studied. However, to remain practically dry under water, additional mechanisms need consideration. This is because trapped gas (e.g. air) in the roughness valleys can dissolve into the water pool, leading to invasion. Additionally, water vapor can also occupy the roughness valleys of immersed surfaces. If water vapor condenses, that too leads to invasion. These effects have not been investigated, and are critically important to maintain surfaces dry under water. In this work, we identify the critical roughness scale, below which it is possible to sustain the vapor phase of water and/or trapped gases in roughness valleys – thus keeping the immersed surface dry. Theoretical predictions are consistent with molecular dynamics simulations and experiments.
Experimental demonstration of interference avoidance protocol (transmission scheduling) in O-CDMA networks (2007)

We experimentally demonstrate a transmission scheduling algorithm to avoid congestion collapse in O-CDMA networks. Our result shows that transmission scheduling increases the performance of the system by orders of magnitude.
The secreted Theileria annulata Ta9 protein contributes to activation of the AP-1 transcription factor (2018)

Theileria annulata is an obligate intracellular protozoan parasite of the phylum Apicomplexa. Theileria sporozoites invade bovine leukocytes and develop into a multinucleate syncytial macroschizont that causes uncontrolled proliferation and dissemination of infected and transformed leukocytes. Activator protein 1 (AP-1) is a transcription factor driving expression of genes involved in proliferation and dissemination and is therefore a key player in Theileria-induced leukocytes transformation. Ta9 possesses a signal peptide allowing it to be secreted into the infected leukocyte cytosol and be presented to CD8 T cells in the context of MHC class I. First, we confirmed that Ta9 is secreted into the infected leukocyte cytosol, and then we generated truncated versions of GFP-tagged Ta9 and tested their ability to activate AP-1 in non-infected HEK293T human kidney embryo cells. The ability to activate AP-1-driven transcription was found to reside in the C-terminal 100 amino acids of Ta9 distant to the N-terminally located epitopes recognised by CD8+ T cells. Secreted Ta9 has therefore, not only the ability to stimulate CD8+ T cells, but also the potential to activate AP-1-driven transcription and contribute to T. annulata-induced leukocyte transformation.
Parallelizing edge drawing algorithm on CUDA (2012)

Parallel computing methods are very useful in speeding up algorithms that can be divided into independent subtasks. Traditional multi-processor architectures have limited use due to their high cost and difficulties of their use. Recently, Graphics Processor Units (GPUs) has opened up a new era for general purpose parallel computation. Among many GPU programming frameworks, Compute Unified Device Architecture (CUDA) seems to be the most widely used GPU architecture due to its low cost and ease of use. In this paper, we show how to implement our recently proposed novel edge segment detector, the Edge Drawing (ED) algorithm, in CUDA, and present performance studies demonstrating the performance gams in the CUDA architecture compared to a uniprocessor CPU implementation. The results show that a CUDA implementation improves the running time of ED by up to 12× and ED runs at an amazing blazing speed of about 1 ms on a 512×512 image. ED is run on different CUDA cards and the performance results are presented.
Session 24 overview: DRAM &#x00026; Flash memories (2010)

This session combines DRAM and NAND Flash memory, which are the two work-horses of the memory industry. Some of the exciting advances that have allowed the adoption of these memory technologies in a variety of consumer electronics are revealed in this session. More and more of these systems are using both DRAM and NAND in their memory sub-systems and in many cases require close coordination between the interface designs of the two memory types.
Microfabricated arrays for fractionation of large DNA molecules via pulsed field electrophoresis (1999)

Novel microfabricated devices promise to accomplish fractionation of chromosomal size DNA more quickly, more accurately, at lower cost, and by using smaller sample amounts. Chromosomes are released by lysing cells directly in the device. The chromosomal DNA is further concentrated on a platinum wire in a 10 μm wide band using the phenomenon of dielectric trapping in AC fields. The DNA is then electrophoretically driven into a microfabricated array of posts arranged in a hexagonal lattice. Under electric fields whose direction periodically changes by 120°, the longer DNA molecules move at lower speeds than the shorter ones, and separation according to size is achieved. This technique allows application of electric fields as large as 1000 V/cm and, thus, promises to reduce considerably separation times compared to the presently used technique of pulsed-field gel electrophoresis.
Near-field Localization with Dynamic Metasurface Antennas (2023)

Sixth generation (6G) cellular communications are expected to support enhanced wireless localization capabilities. The widespread deployment of large arrays and high-frequency bandwidths give rise to new considerations for localization applications. Emerging antenna architectures, such as dynamic metasurface antennas (DMAs), are expected to be frequently utilized thanks to the achievable high angular resolution and low hardware complexity. Further, wireless localization is likely to take place in the radiating near-field (Fresnel) region, which provides new degrees of freedom, because of the adoption of arrays with large apertures. While current studies mostly focus on the use of costly fully-digital antenna arrays, in this paper we investigate how DMAs can be applied for near-field localization of a single user. We use a direct positioning estimation method based on curvature-of-arrival of the impinging wavefront to obtain the user location, and characterize the effects of DMA tuning on the estimation accuracy. Next, we propose an algorithm for configuring the DMA to optimize near-field localization, by first tuning the adjustable DMA coefficients to minimize the estimation error using postulated knowledge of the actual user position. Finally, we propose a sub-optimal iterative algorithm that does not rely on such knowledge. Simulation results show that the DMA-based near-field localization accuracy could approach that of fully-digital arrays at lower cost.
Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island (2008)

Chronic exposure to inducers of DNA base oxidation and single and double strand breaks contribute to tumorigenesis. In addition to the genetic changes caused by this DNA damage, such tumors often contain epigenetically silenced genes with aberrant promoter region CpG island DNA hypermethylation. We herein explore the relationships between such DNA damage and epigenetic gene silencing using an experimental model in which we induce a defined double strand break in an exogenous promoter construct of the E-cadherin CpG island, which is frequently aberrantly DNA hypermethylated in epithelial cancers. Following the onset of repair of the break, we observe recruitment to the site of damage of key proteins involved in establishing and maintaining transcriptional repression, namely SIRT1, EZH2, DNMT1, and DNMT3B, and the appearance of the silencing histone modifications, hypoacetyl H4K16, H3K9me2 and me3, and H3K27me3. Although in most cells selected after the break, DNA repair occurs faithfully with preservation of activity of the promoter, a small percentage of the plated cells demonstrate induction of heritable silencing. The chromatin around the break site in such a silent clone is enriched for most of the above silent chromatin proteins and histone marks, and the region harbors the appearance of increasing DNA methylation in the CpG island of the promoter. During the acute break, SIRT1 appears to be required for the transient recruitment of DNMT3B and subsequent methylation of the promoter in the silent clones. Taken together, our data suggest that normal repair of a DNA break can occasionally cause heritable silencing of a CpG island-containing promoter by recruitment of proteins involved in silencing. Furthermore, with contribution of the stress-related protein SIRT1, the break can lead to the onset of aberrant CpG island DNA methylation, which is frequently associated with tight gene silencing in cancer.
Spin-orbit torque in Cr/CoFeAl/MgO and Ru/CoFeAl/MgO epitaxial magnetic heterostructures (2016)

We study the spin-orbit torque (SOT) effective fields in Cr/CoFeAl/MgO and Ru/CoFeAl/MgO magnetic heterostructures using the adiabatic harmonic Hall measurement. High-quality perpendicular-magnetic-anisotropy CoFeAl layers were grown on Cr and Ru layers. The magnitudes of the SOT effective fields were found to significantly depend on the underlayer material (Cr or Ru) as well as their thicknesses. The damping-like longitudinal effective field (ΔHL) increases with increasing underlayer thickness for all heterostructures. In contrast, the field-like transverse effective field (ΔHT) increases with increasing Ru thickness while it is almost constant or slightly decreases with increasing Cr thickness. The sign of ΔHL observed in the Cr-underlayer devices is opposite from that in the Ru-underlayer devices while ΔHT shows the same sign with a small magnitude. The opposite directions of ΔHL indicate that the signs of spin Hall angle in Cr and Ru are opposite, which are in good agreement with theoretical predictions. These results show sizable contribution from SOT even for elements with small spin orbit coupling such as 3d Cr and 4d Ru.
Ivabradina, insufficienza cardiaca e malattia renale cronica (2015)

Abstract non disponibile (Cardionephrology)
Characterization and electrical analysis of carbon-based solid lubricant coatings (2022)

The use of electrical devices has skyrocketed over the past decades, increasing the demand for electrical connectors worldwide. Therefore, it is of utmost importance to produce more reliable, energy and material efficient, and durable electrical contact material systems; particularly in low-redundancy systems, such as in passenger vehicles. This work analyzes the potential use of carbon nanoparticle coatings applied via electrophoretic deposition over copper substrates to reduce wear, require lower insertion forces, and to protect the connectors from atmospheric conditions, while reducing the gain on the overall resistance of the system. Four carbon nanoparticles were considered due to their well-known solid-lubricating capabilities, namely: graphite flakes, graphene oxide, carbon nanotubes, and carbon nanohorns. Through a comprehensive characterization of the coatings, aspects like coating topography, compactness, thickness, elasticity, and electrical contact resistance were analyzed. Carbon nanotubes and nanohorns proved to have the highest potential. In addition to their previously documented outstanding solid-lubricity and environmental protection - after chemical modification of the coatings’ surfaces - these nanoparticles showed low resistance values for loads above 4 N, i.e., below 400 mΩ. Moreover, the coatings produced were thin and homogeneous, with adequate mechanical stability, and elastic behavior.
Solvent-induced membrane stress in biofuel production: molecular insights from small-angle scattering and all-atom molecular dynamics simulations (2020)

Small-angle-scattering and molecular simulation reveal the disruptive impact of organic solvents on model microbial membranes limiting the economical production of green fuels and value-added chemicals from lignocellulose (Image by: Jill Hemman, ORNL).
Modelling of the Plastisol Knife Over Roll Coating Process (2017)

Abstract The knife-over-roll coating process of plastisol formulations for flooring applications has been investigated. The coexistence of smooth spherical PVC particles and rough calcium carbonate aggregates in a Newtonian plasticizer makes this suspension a more complex system than those encountered in the literature. The shear viscosity has been measured with Couette and capillary devices in the wide range of shear rates encountered in the process, resulting in a non-monotonous viscosity curve. A numerical model based on the lubrication approximation theory allows accounting for this non-monotonous behavior. It predicts the deposited thickness, the pressure field between roll and knife and the separating force as a function of the plastisol rheology and the coating parameters.
Elasticity and hardness of nano-polycrystalline boron nitrides: The apparent Hall-Petch effect (2014)

Nano-polycrystalline boron nitride (BN) is expected to replace diamond as a superhard and superstiff material. Although its hardening was reported, its elasticity remains unclear and the as-measured hardness could be significantly different from the true value due to the elastic recovery. In this study, we measured the longitudinal-wave elastic constant of nano-polycrystalline BNs using picosecond ultrasound spectroscopy and confirmed the elastic softening for small-grain BNs. We also measured Vickers and Knoop hardness for the same specimens and clarified the relationship between hardness and stiffness. The Vickers hardness significantly increased as the grain size decreased, while the Knoop hardness remained nearly unchanged. We attribute the apparent increase in Vickers hardness to the elastic recovery and propose a model to support this insight.