gebhart/patrepeval huggingface dataset:
High performance, integrated 1T1R oxide-based oscillator: Stack engineering for low-power operation in neural network applications (2015)

Brain-inspired non-Boolean computing paradigms are gaining wide interest due to their error resilient nature and massive parallelism. This work explores oxide-based compact oscillators for oscillatory neural networks (ONN). We demonstrate for the first time, best in class high-frequency performance at 500 MHz and low power (<; 200 μW). The superior figures of merit are achieved due to device engineering to give maximum swing at low power and integration as a 1T1R structure. We show frequency control over 2 orders of magnitude by varying the gate voltage and show its applicability to an ONN-based associative memory.
69. Potent pressor response to hypoxia in awake sleep apnea patients (1991)

The journal consistently attracts the most important and highly innovative papers from the current research; our commitment to rapid publication ensures that these are published in the fastest time possible. In addition to primary papers from world-renowned experts, the Journal contains authoritative reviews that summarize and evaluate the most significant recent developments. Also included are special reports, original short papers containing innovative and time-sensitive information. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool. ​ Official Journal of the: International Society of Hypertension European Society of Hypertension
Response to Comment on Tang et al. Effects of Insulin Glargine and Liraglutide Therapy on Liver Fat as Measured by Magnetic Resonance in Patients With Type 2 Diabetes: A Randomized Trial. Diabetes Care 2015;38:1339–1346 (2015)

Shan et al. (1) raise important points regarding treatment duration, sample size, mean values of magnetic resonance (MR)-based biomarkers, and severity of liver steatosis in our study (2).

The 12-week duration of our study was justified by the exploratory aim to compare two second-line injectable treatment alternatives on liver steatosis as measured by MR-based techniques. To acknowledge that the study duration was too short to address the long-term effects on liver steatosis, we preemptively stated in our discussion that “a longer study would have favored GLP-1 agonist therapy in terms of body weight loss and, possibly, a concomitant reduction in the liver fat fraction” …
Annealing of Te-implanted GaAs by ruby laser irradiation (1978)

A single pulse of ruby laser radiation is shown to cause significant regrowth in the amorphous region of heavily ion-implanted GaAs. The implanted Te atoms and the host material both show good channeling dips, suggesting essentially complete substitutionality of the Te. There has been only a minor redistribution of the tellurium atoms. The resulting local Te concentration in the laser-irradiated sample is more than ten times the known maximum solubility of Te in GaAs.
A novel four-leg three-phase inverter control strategy to reduce the data center thermal losses: Elimination of neutral current (2012)

In this paper a novel control strategy is proposed for a three-phase-four-leg UPS-inverter for data center application. The control strategy takes care of the unbalanced three-phase loading of the data center server without the manifestation of the neutral current. Thus, the power distribution unit (PDU) transformer can be eliminated from the power architecture while feeding the total data center load from a standard three-phase-three-wire utility supply. The proposed control strategy adjusts the inverter output voltages in such a way that even in the presence of unbalanced loading of the servers, the neutral current is maintained at zero in the steady-state. The proposed methodology is thus capable of reducing the thermal losses due to PDU as well as neutral wire improving the power usage efficiency (PUE) of the date center.
p38γ Promotes Breast Cancer Cell Motility and Metastasis through Regulation of RhoC GTPase, Cytoskeletal Architecture, and a Novel Leading Edge Behavior (2011)

Understanding the molecular alterations that confer cancer cells with motile, metastatic properties is needed to improve patient survival. Here, we report that p38γ motogen-activated protein kinase regulates breast cancer cell motility and metastasis, in part, by controlling expression of the metastasis-associated small GTPase RhoC. This p38γ-RhoC regulatory connection was mediated by a novel mechanism of modulating RhoC ubiquitination. This relationship persisted across multiple cell lines and in clinical breast cancer specimens. Using a computational mechanical model based on the finite element method, we showed that p38γ-mediated cytoskeletal changes are sufficient to control cell motility. This model predicted novel dynamics of leading edge actin protrusions, which were experimentally verified and established to be closely related to cell shape and cytoskeletal morphology. Clinical relevance was supported by evidence that elevated expression of p38γ is associated with lower overall survival of patients with breast cancer. Taken together, our results offer a detailed characterization of how p38γ contributes to breast cancer progression. Herein we present a new mechanics-based analysis of cell motility, and report on the discovery of a leading edge behavior in motile cells to accommodate modified cytoskeletal architecture. In summary, these findings not only identify a novel mechanism for regulating RhoC expression but also advance p38γ as a candidate therapeutic target.
Preventive Cardiology: The SHAPE of the Future (2010)

In the twentieth century, atherosclerotic cardiovascular disease (ACVD) manifesting as a “heart attack,” has claimed millions of lives every year, and killed more people than all wars combined. An epidemic of this magnitude makes it very difficult to imagine a future in which heart attacks are eradicated. Nonetheless, the mission of eradicating heart attacks is no more challenging than the mission of landing humans on Mars. The vision for a heart attack-free future can become a reality in the twenty-first century and can significantly increase human life expectancy. This goal is achievable if we, including academia, industry, health-care providers, payers, and policymakers, invest in the detection and treatment of asymptomatic atherosclerotic as much as we have invested in the treatment of symptomatic atherosclerosis. Primary prevention of ACVD, through treatment of risk factors of atherosclerosis, public education, and promotion of heart-healthy life style, has been the main focus of cardiovascular organizations such as the American Heart Association. However, the continued overwhelming burden of ACVD and disappointing trends in the prevalence of ACVD risk factors, particularly obesity and diabetes, have made it clear that traditional methods are inadequate and new strategies are urgently needed. Recent discoveries have created paradigm shifts in our understanding of the underlying mechanisms of ACVD and the sequence of events that result in athero-thrombotic events. These scientific discoveries, along with new diagnostic and therapeutic developments, have opened the way to unprecedented opportunities including (1) screening for early detection and aggressive treatment of the “vulnerable patient” based on noninvasive imaging of asymptomatic atherosclerosis, (2) monitoring therapies and evaluating progression or regression of the disease based on structural, functional, and molecular markers of ACVD, (3) development of safe and effective “Polypills” for preemptive population-based therapy, (4) development of safe and effective focal therapies, such as bio-absorbable drug-eluting stents, for rapid stabilization of the “vulnerable plaque,” and (5) immune modulation and vaccination strategies for prevention of atherosclerosis at an early age and halting its progression later in life. Simultaneously, the fast evolving IT and communication technologies, as well as low-cost home health-monitoring devices, will facilitate rapid dissemination of new information, empower consumers, and help shift cardiovascular care from hospitals to the home. Through the above, our modern preventive cardiology will shape the future and will lead to the eradication of heart attack in the twenty-first century.
Apoptotic body–loaded dendritic cells efficiently cross‐prime cytotoxic T lymphocytes specific for NA17‐A antigen but not for Melan‐A/MART‐1 antigen (2002)

DCs hold promise for cancer immunotherapy due to their functional ambivalence: iDCs internalize antigens, then mDCs trigger naive T-cell activation. However, no consensus has been reached concerning the optimal mode of antigen acquisition for efficient cross-priming of TAA-specific CTLs, and this remains a field of investigation. Here, we used highly purified apobodies derived from an HLA-A*0201-negative melanoma line as a source of tumor antigens for HLA-A*0201 DCs. We compared in vitro mDCs loaded with apobodies to DCs loaded with antigenic peptides, NA17-A(1-9) and Melan-A/MART-1(26-35) A27L analogue, for their capacity to stimulate melanoma antigen-specific T cells from autologous PBLs. Apobody phagocytosis did not induce spontaneous DC maturation, but phagocytic DCs were still responsive to maturation signals, resulting in a functional ability to activate antigen-specific lymphocytes. NA17-A-specific T lymphocytes were activated by both types of stimulation, whereas only peptide-pulsed DCs stimulated the growth of Melan-A/MART-1-specific lymphocytes. We also observed a lack of staining of melanoma-derived apobodies with a Melan-A-specific MAb, suggesting protein alteration during apoptosis induction. After HLA-A*0201/NA17-A multimer sorting, antigen-specific lymphocytes induced by mature DCs loaded with either peptide or apobodies displayed similar functional capacity against peptide-pulsed T2 cells and melanoma cells. Therefore, apobody-loaded DCs can achieve T-cell priming similar to that induced by peptide-pulsed DCs, provided that the apoptotic process allows the preservation of antigen expression.
"Codes" on images and iterative phase unwrapping (2002)

Many imaging techniques, including magnetic resonance imaging and interferometric synthetic aperture radar, produce "phase-wrapped" images. In a phase-wrapped image, the original image values are measured modulus a known wavelength, A. The goal of phase unwrapping is to produce an estimate of the original image using an a priori preference for smooth images. We formulate phase unwrapping as the problem of computing a vector field that is an estimate of the gradient field of the original image. A preference for smooth images is obtained using a Gaussian prior on the vector field. For a vector field to be a gradient field, it must satisfy the constraint that the sum of the vectors around every closed loop is zero. We enforce this constraint using "zero-curl checks" in a factor graph on the vector field. The sum-product algorithm in this factor graph is used to approximately compute the posterior probabilities of the vectors. Hard decisions are used to produce a vector field, which is integrated to obtain the unwrapped image. Experimental results show that this method can work significantly better than existing techniques for phase unwrapping. Although phase unwrapping for general image priors is NP-hard, we conjecture that the sum-product algorithm in an appropriate factor graph will lead to a near-optimal unwrapping algorithm for Gaussian process sources.
Fine and Clean Photothermally Controlled NIR Drug Delivery from Biocompatible Nickel‐bis(dithiolene)‐Containing Liposomes (2017)

This work demonstrates that metal-bis(dithiolene) complexes can be efficiently incorporated inside organic nanocarriers and, that under near-infrared (NIR) irradiation, their high photothermal activity can be finely used to release encapsulated drugs on demand. In contrast to gold nanoparticles and other organic NIR dyes, nickel-bis(dithiolene) complexes do not produce singlet oxygen under irradiation, a highly desirable characteristic to preserve the chemical integrity and activity of the loaded drug during the NIR-triggered release from the nanocarriers. Finally, cytotoxicity experiments performed on various cell lines have shown that the incorporation of such metal complexes do not increase the toxicity of the final liposomal formulation. These results offer great promise for the development of innovative biocompatible drug nanocargos that are able to safely deliver their content on demand under NIR laser irradiation. Moreover, this work demonstrates that metal-bis(dithiolene) complexes, owing to their versatility of functionalization and metal complexation, are attractive photothermal agents for the development of original NIR-responsive materials for application not only in biotechnology but also in materials science.
Optical imaging of anatomical maps derived from magnetic resonance images using time-independent optical sources (1997)

We present a model suitable for computing images of absorption cross sections of thick tissue structures illuminated at near infrared (NIR) wavelengths from tomographic projection data. Image reconstruction is accomplished by solving a system of linear equations derived from transport theory. Reconstruction results using different algebraic solvers are shown for anatomical maps of the breast, derived from magnetic resonance imaging data, containing two simulated pathologies, in which case qualitatively good reconstructions were obtained. Evaluation of magnetic resonance (MR) data to optimize NIR optical tomographic imaging methods and to assess the feasibility of a combined MR-optical measurement scheme is discussed.
Treatment of a persistent cervical dural tear (2019)

Intraoperative incidental durotomies may occur in as many as 1% of cervical spine surgeries. The expectation of treatment is healing of the dural tear with resolution of the symptoms. The only strong contraindication for surgical intervention in cases of a severe persistent cervical dural tear is a medical condition that would not allow the patient to be treated safely under general anesthesia. The operative team may also benefit from having a kit for placement of a subarachnoid drain in the event that cerebrospinal fluid diversion is required. Introperative spinal cord monitoring with SSEM and motor-evoked potentials may be helpful in confirming that the operative position is tolerated by the patient and that the spinal cord function remains intact through the surgical intervention. Additionally, symptoms of meningitis should also be sought. The factors should be emphasized during the treatment of a persistent cervical dural tear: watertight closure, tight wound closure, upright positioning, and optimal nutrition.
Phage Infection Restores PQS Signaling and Enhances Growth of a Pseudomonas aeruginosa lasI Quorum-Sensing Mutant (2022)

Chemical communication between bacteria and between bacteria and the bacteriophage (phage) viruses that prey on them can shape the outcomes of phage-bacterial encounters. Quorum sensing (QS) is a bacterial cell-to-cell communication process that promotes collective undertaking of group behaviors. QS relies on the production, release, accumulation, and detection of signal molecules called autoinducers. Phages can exploit QS-mediated communication to manipulate their hosts and maximize their own survival. In the opportunistic pathogen Pseudomonas aeruginosa, the LasI/R QS system induces the RhlI/R QS system, and in opposing manners, these two systems control the QS system that relies on the autoinducer called PQS. A P. aeruginosa Δ<i>lasI</i> mutant is impaired in PQS synthesis, leading to accumulation of the precursor molecule HHQ, and HHQ suppresses growth of the P. aeruginosa Δ<i>lasI</i> strain. We show that, in response to a phage infection, the P. aeruginosa Δ<i>lasI</i> mutant reactivates QS, which, in turn, restores <i>pqsH</i> expression, enabling conversion of HHQ into PQS. Moreover, downstream QS target genes encoding virulence factors are induced. Additionally, phage-infected P. aeruginosa Δ<i>lasI</i> cells transiently exhibit superior growth compared to uninfected cells. <b>IMPORTANCE</b> Clinical isolates of P. aeruginosa frequently harbor mutations in particular QS genes. Here, we show that infection by select temperate phages restores QS, a cell-to-cell communication mechanism in a P. aeruginosa QS mutant. Restoration of QS increases expression of genes encoding virulence factors. Thus, phage infection of select P. aeruginosa strains may increase bacterial pathogenicity, underscoring the importance of characterizing phage-host interactions in the context of bacterial mutants that are relevant in clinical settings.
Miscorrelation of Functional Outcome and Sociooccupational Status of Childhood, Adolescent, and Young Adult Generation With Bone and Soft Tissue Sarcoma Patients (2019)

Few studies have examined the relationship between functional outcome and sociooccupational or psychological status in adolescent and young adults (AYA) generation and childhood sarcoma patients. We retrospectively analyzed clinical (prognostic and functional) and sociooccupational outcomes in 50 patients; 22 children aged under 14 years and 28 AYAs generation (15 to 29 y). There were 35 cases of bone sarcomas and 15 of soft tissue sarcomas. Limb-sparing surgery was performed in 30 of 37 extremity cases. The most prevalent problems among patients were as follows: limited activities; drop-out or delayed studies among high school and college students; limitation in job searching; and changes in social relationships. These problems were unaffected by limb-sparing. Regression analysis between functional and sociooccupational disability showed that the correlation coefficient was significant (P=0.005) in all limb-salvaged patients, but there was no significant correlation among osteosarcoma patients (P=0.07). These findings suggest that quality of life is a multidimensional measure: it depends on physical status, spiritual health, and social well-being of both patients and family members. To overcome the disadvantages of this type of disease, it is essential to provide comprehensive care at the earliest convenience using multidimensional approaches.
Mechanical properties and microstructure of 6061 aluminum alloy severely deformed by ARB process and subsequently aged at low temperatures (2014)

In order to clarify the aging behavior in ultrafine grained (UFG) Al alloys, a commercial Al-Mg-Si alloy was severely deformed by accumulative roll-bonding (ARB) process and subsequently aged at 100°C or 170°C. The age-hardening behavior and microstructure change during aging were investigated. At 170 °C, age-hardening was observed in solution treated (ST) specimens, but solution-treated and ARB-processed specimens were not hardened by aging. On the other hand, the hardness of the both ST specimen and ARB-processed specimen increased by aging at 100°C. From TEM observation, it was found that the ARB- processed specimen had an ultrafine lamellar boundary structure and the structure was kept during aging at 170°C and 100°C. In the ST specimen aged at 170°C, fine precipitates were observed within coarse grains. In the specimen ARB-processed and subsequently aged at 170°C, coarser precipitates were observed within ultrafine grains and on grain boundaries. It was considered that the reason why the hardness of the specimens ARB-processed and subsequently aged did not increase was coarsening of precipitates. In the specimens aged at 100°C, obvious precipitates were not observed, but clusters Mg and Si seemed to form during the aging, leading to the increase in the hardness of the specimen. From the results, it was suggested that aging at low temperatures could improve mechanical properties of Al alloys through combining grain refinement and precipitation hardening.
Characterisation, analysis and optical properties of nanostructure ZnO using the sol–gel method (2012)

Nanostructure ZnO was grown on thin aluminium layer, deposited on silicon substrate using the sol–gel method. The surface morphologies of nanostructure ZnO at different precursor concentrations were studied using scanning electron microscopy. Raman spectroscopy suggested that nanorods started to grow along with nanoflakes at a precursor concentration of 50 mM and the density of the nanorods significantly increases when the concentration was raised to 75 mM. Raman spectra were intensified and red shifted with the increment of precursor concentration. Optical properties of refractive index and optical dielectric constant are investigated. The structural defects at lower level of precursor were probably due to the hypoxic environment, whereas the red shift of Raman spectra was due to the structural change of ZnO nanocrystals.
Maliciously circuit-private multi-key FHE and MPC based on LWE (2022)

Abstract In this paper, we construct multi-key homomorphic and fully homomorphic encryption (resp. MKHE and MKFHE) schemes with malicious circuit privacy. Our schemes are based on learning with errors (LWE) besides appropriate circular security assumptions. In contrast, the previous maliciously circuit-private MKFHE scheme by Chongchitmate and Ostrovsky (PKC, 2017) is based on the non-standard decisional small polynomial ratio (DSPR) assumption with a super-polynomial modulus, besides ring learning with errors and circular security assumptions. We note that it was shown by Albrecht et al. (CRYPTO, 2016) that there exists a sub-exponential time attack against this type of DSPR assumption. The main building block of our maliciously circuit-private MKFHE scheme is a (plain) MKFHE scheme by Brakerski et al. (TCC, 2017), and the security of our schemes is proven under the hardness of LWE with sub-exponential modulus-to-noise ratio and circular security assumptions related to the Brakerski et al. scheme. Furthermore, based on our MKFHE schemes, we construct four-round multi-party computation (MPC) protocols with circuit privacy against a semi-honest server and malicious clients in the plain model. The protocols are obtained by combining our schemes with a maliciously sender-private oblivious transfer protocol and a circuit garbling scheme, all of which can be instantiated only assuming LWE.
Time course of the vasoactive response for sonoreperfusion therapy using long tone burst ultrasound (2018)

We have previously shown that sonoreperfusion (SRP) using ultrasound (US) and microbubble (MB) can restore perfusion following microvascular obstruction and is mediated by nitric oxide vasodilation. Here, we compared the use of short (SP-10 cycles) and long (LP-5000 cycles) pulses for SRP and investigated the vasoactive response time-course and the downstream signaling 4 h post-treatment. In a rat hindlimb, we applied LP or SP (1 MHz,1.5 MPa) with the same number of acoustic cycles for 2 min during MB infusion. Both pulses affected the perfusion rate but with distinct temporal responses. For SP, the flow rate peaked (12.3±3.4 dB/s) at 15 min but returned to baseline (BL)(3.2±0.8 dB/s) after 60 min. Conversely, for LP, the flow rate also initially dropped but started to increase at 6 min and peaked (13.0±2.1 dB/s) at 15 min and was still high (8.3±2.0 dB/s) after 4 h compared to BL and SP. This sustained increase in flow rate, which was different from reactive hyperemia, was concordant with 2.5-fold increases in phosphorylated and total eNOS expression (Western blot) compared to untreated tissue, and consistent with a 2-fold increase in eNOS transcription (qPCR). These data support that long pulse SRP therapy increased in muscle perfusion for at least 4 h consistently with increased eNOS transcription and expression.