gebhart/patrepeval huggingface dataset:
Systematic Qualification Test Procedure to Evaluate New CRA Material, 17-Chrome (2016)

Abstract A new Oil Country Tubular Goods (OCTG) Corrosion Resistant Material (CRA) 17-Chrome (17CR) was introduced in late 2011. The corrosion resistance performance of such material was claimed to be comparable to a higher grade material of duplex stainless steel 22-Chrome (22CR) under a given aggressive corrosion environment. In addition to that, 17CR was expected to be significantly competitive and commands shorter delivery lead time compared to 22CR as it does not require cold-drawing process to achieve the required high yield strength. PCSB had evaluated this new material for one of its massive LNG development projects through a series of qualification testing. These LNG carbonate fields were highly corrosive with CO2 and H2S content up to 22 mol% and 140ppm respectively. Maximum bottom hole temperature anticipated was more than 180 degrees Celsius. Material selection for production tubing was therefore of paramount importance in such severe well condition to ensure that long term well integrity was not compromised with this newly developed material. Through the establishment of a multidisciplinary team, PCSB had established a set of rigorous qualification test procedure, fully aligned with industry standards to ensure that the identified risks were mitigated from both material and connection perspectives. This paper will describe the systematic approach that was used to evaluate the reliability of the new material with a premium connection under the defined worst case conditions; discuss the corresponding results which led to significant cost savings for the mentioned project.
Selective inhibitors of nuclear export for the treatment of non-Hodgkin's lymphomas (2013)

The nuclear export protein chromosome maintenance region 1, found to be elevated in non-Hodgkin's lymphomas, controls localization of critical tumor suppressor proteins. Nuclear localization of tumor suppressor proteins is necessary for their cell surveillance function. However, their nuclear exclusion by chromosome maintenance region 1 renders them ineffective making this nuclear transporter an attractive therapeutic target. We have identified selective inhibitors of nuclear export that lock tumor suppressor proteins in the cell nucleus leading to apoptosis of lymphoid but not normal cells. Our inhibitors induce tumor suppressor protein nuclear retention-dependent growth inhibition and apoptosis in a panel of non-Hodgkin's lymphoma cell lines. Western blot of nuclear protein fraction and confocal microscopy analysis demonstrated retention of major tumor suppressor proteins in the cell nucleus. Co-immunoprecipitation studies showed disruption of the tumor suppressor protein-chromosome maintenance region 1 interaction. Small inhibitor RNA knockdown of two major tumor suppressor proteins, p53 in wild-type protein-53 and protein 73 in mutant-protein-53, abrogated inhibitor activity. Oral administration of related inhibitor at 75 and 150 mg/kg resulted in 65 and 70% tumor reduction, respectively and subcutaneous injections of inhibitor (25 and 75 mg/kg) resulted in 70 and 74% suppression of non-Hodgkin's lymphoma tumor growth with no toxicity; residual tumors showed activation of the protein 73 pathway. Our study verifies chromosome maintenance region 1 as a therapeutic target in non-Hodgkin's lymphoma, indicating that this nuclear export protein warrants further clinical investigations.
University approach for circuit breaker development (2009)

Activities in the university were described for a circuit breaker development. To make experimental facilities minimized several new approaches were adopted. A accurate model investigation was focused in a transient analysis. A MEMS sensor application was aimed for a diagnosis. A small scale facility made an arcing phenomenon research possible. A new material application was achieved successfully. (4 pages)
Air-Coupled Ultrasonic Ferroelectret Receiver with Additional DC Voltage (2017)

Highly sensitive air-coupled ultrasonic sensors are essential for various applications such as testing of composite materials. One of the major challenges for the development of air-coupled ultrasonic sensors is the impedance matching to air. With a lower acoustic impedance than the usual piezoelectric materials, charged cellular polypropylene film (cPP) offers better matching to air with a similar piezoelectric coefficient. The piezoelectric behaviour demonstrated by cPP comes from polarized air cells that create a permanent internal voltage. The sensitivity of the sensor varies with the application of an additional DC bias voltage. Thus, this work presents a cPP ultrasonic sensor with an improvement of up to 15 1 dB on the signal-to-noise ratio.
Block-fading broadcast channel with hybrid CSIT and CSIR (2017)

The broadcast channel under delayed, mixed, hybrid, or no CSIT Is a subject of much Interest but has been studied only under i.i.d. fading and perfect CSIR for all users. Models that go beyond i.i.d. fading and perfect CSIR are of practical Importance since users may experience unequal fading block-length (coherence time) and unequal CSIR availability due to different mobility and scattering environment. This paper studies a two-user MISO broadcast channel with hybrid CSIR, where one static user (with slower fading) has CSIR and one dynamic user (with faster fading) does not have free CSIR. Under this hybrid CSIR condition, the paper studies the degrees of freedom under various CSIT scenarios: no, delayed, and hybrid CSIT. For no CSIT, we provide an outer bound that meets the achievable degrees of freedom region when the coherence times of the users are the same. For both delayed and hybrid CSIT, the achievable regions partially meet their corresponding outer bounds, and furthermore the corresponding gaps decrease with the dynamic user coherence time.
Conducting Simulations in Causal Inference with Networks-Based Structural Equation Models (2017)

The past decade has seen an increasing body of literature devoted to the estimation of causal effects in network-dependent data. However, the validity of many classical statistical methods in such data is often questioned. There is an emerging need for objective and practical ways to assess which causal methodologies might be applicable and valid in network-dependent data. This paper describes a set of tools implemented in the simcausal R package that allow simulating data based on user-specified structural equation model for connected units. Specification and simulation of counterfactual data is implemented for static, dynamic and stochastic interventions. A new interface aims to simplify the specification of network-based functional relationships between connected units. A set of examples illustrates how these simulations may be applied to evaluation of different statistical methods for estimation of causal effects in network-dependent data.
Quantitative Evaluation of Microstructure in Mo-Si-B-TiC Alloy Produced by Melting and Tilt Casting Methods (2017)

Mo-Si-B-TiC alloys are expected to be a candidate for an ultrahigh-temperature material beyond Ni-base superalloys. This work quantitatively investigated the microstructure of a Mo-Si-B-TiC alloy with the composition of Mo-5Si-10B-10TiC (65Mo alloy) (at%) produced via arc-melting and tilt-casting techniques. The alloy was composed of four constituent phases: Mo solid solution (Moss), Mo5SiB2(T2), (Ti, Mo)Cx, (Mo, Ti)2C, and their eutectic (or peritecteutectic) phases. The compositions of the constituent phases were determined by electron beam micro analyzer (EPMA). Scanning electron microscopy – backscattered electron diffraction (SEM-EBSD) measurements revealed that T2 and (Ti, Mo)Cx phases have orientation relationships with Mo phase: {110}Mo//(001)T2, <111>Mo//<001>T2 and {110}Mo//{111}(Ti,Mo)Cx, <111>Mo//<001>(Ti,Mo)Cx. Furthermore, the three-dimensional SEM observation with the combination of the focused ion beam (FIB) serial sectioning technique demonstrated that the T2 phase had a thin plate shape with the orientation of (001) as plate surfaces and of {100} as side ones.
H3 Receptor Target: Past, Present, and Future Perspectives from Worldwide H3 Experts (2008)

The histamine H3 receptor (H3R) was first characterized, in 1983, as a presynaptic autoreceptor controlling histamine release in the brain using existing H1 and H2 antagonists as probes in a classical pharmacological approach. A high constitutive activity of this receptor coupled with the fact that its ligands displayed protean agonism as well as a lot of pharmacological heterogeneity found among various species and the human receptors complicated the H3R pharmacology. In the late 1990s, two major breakthroughs occurred to reignite the H3 field. First, the human H3R was cloned, allowing the detailed investigation of H3 pharmacology in a homogenous system and the initiation of several high-throughput screening efforts. Second, nonimidazole-based antagonists were discovered, providing the opportunity to circumvent the suboptimal properties of first-generation imidazole-based H3 antagonists. Various nonimidazole H3R ligands were then developed by efforts of various pharmaceutical companies and academic research groups.
Supplementary Table 1 from Network Analysis Identifies an HSP90-Central Hub Susceptible in Ovarian Cancer (2023)

&lt;p&gt;XLSX file - 55KB, Sensitization ranking across five independent drug sensitization screens.&lt;/p&gt;
Perioperative Testing for Joint Infection in Patients Undergoing Revision Total Hip Arthroplasty (2008)

A synovial fluid cell count of >3000 white blood cells/mL was the most predictive perioperative testing modality in our study for determining the presence of periprosthetic infection when combined with an elevated preoperative erythrocyte sedimentation rate and C-reactive protein level in patients undergoing revision total hip arthroplasty.
Table S2 from A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors (2023)

&lt;p&gt;Correlation between CEA TCB response and genetic data&lt;/p&gt;
Relating Pore Structure to Activity at the Subcrystal Level for ZSM-5: An Electron Backscattering Diffraction and Fluorescence Microscopy Study (2008)

The catalytic performance of microporous materials such as zeolites is determined not only by the active sites' molecular architecture, but also by the organization of the surrounding pores with varying diameter, shape, and directionality. These pores control transport of reagents and products and induce shape selectivity. Rather than being ideal single crystals, zeolites often have complex 3-dimensional morphologies, comprising intergrowths and various defect types. Here, the underlying pore architecture of the hexagonal facet of an individual zeolite ZSM-5 crystal is successfully determined by electron beam scattering diffraction and is correlated with the initial reactivity toward the acid-catalyzed oligomerization of furfuryl alcohol using polarized fluorescence microscopy.
Efficient 6LoWPAN Neighbor Discovery applied to Multilink IoT subnets (2015)

One fundamental component of the IPv6 protocol suite, the Neighbor Discovery (ND) protocol, is undergoing a major evolution to adapt to the needs of mobile and low-power devices. The traditional model of multicast-based advertisements is being extended with a registration mechanism that exhibits a number of interesting properties. This paper explores how this new model, called Efficient-ND or Wireless ND (WiND), can be used as an open abstraction for any IPv6 mesh network, and can enable the interconnection of multiple such meshes over a federating backbone, effectively forming what the IETF refers to as a “MultiLink subnet”. A method based on IPv6-ND proxy operation is demonstrated on a prototype based on existing industrial-class systems.
Unrestricted CTL recognition of HFE, an empty-peptide-groove MHC class I molecule controlling iron metabolism highlights its potential role as a major histocompatibility antigen in unrelated bone marrow tranplantation (2004)

Unrestricted cytolytic T lymphocytes (CTL) responses against human HFE, a non classical MHC class I molecule with an empty peptide groove which controls iron metabolism, were induced in HLA-A∗0201 transgenic/H-2 class I knock-out mice. HFE recognition was mediated by the alpha-beta T cell receptor. Similar unrestricted CTL responses against mouse HFE molecule were induced in DBA/2 HFE knock-out mice. Predominant usage of AV α6 segments was documented, contrasting with diversified Vβ segment usage. Thus absence of bound ligand to a histocompatibility class I molecule does not preclude αβ TCR interaction. These results support the hypothesis that the immune system could participate in the control of iron metabolism and indicate a novel unrestricted allogenic recognition mechanism that could explain the high proportion of allogenic cytotoxic precursors encountered in any individual. Ten to 15% of the individuals carry a mutated H41D HFE molecule. Since HFE is encoded on the chromosome 6 and thus cosegregates with the HLA haplotypes in siblings, a HFE mismatch in related transplant is unlikely. In contrast, investigating the frequency of a donor-recipient HFE mismatch in a series of 60 unrelated bone marrow transplants otherwise perfectly matched on the HLA-A,B,C,DRB1,DQB1 loci, we found a mismatch in 10 cases. These data suggest that HFE could be a potent histocompatibility antigen in humans in view of its structural polymorphism.
Efficacy of adjuvant trastuzumab (T) compared with no T for patients (pts) with HER2-positive breast cancer and tumors ≤ 2cm: A meta-analysis of the randomized trastuzumab trials. (2014)

508 Background: Adjuvant T plus chemotherapy improves disease-free survival (DFS) and overall survival (OS) vs. chemotherapy alone for pts with early stage HER2-positive breast cancer. We conducted a meta-analysis to estimate DFS and OS for pts with small tumors (≤2cm) in the T arms from 5 of the 6 randomized adjuvant trastuzumab trials. Pts with tumors ≤2cm, with 0 or 1 positive lymph nodes, and hormone receptor (HR) positive disease had a 5-year DFS of 91% and a 5-year OS of 97% (O’Sullivan, SABCS 2013; abstract:1327). We now plan to conduct an additional meta-analysis to assess the efficacy of T compared with no T for pts with small tumors (≤2cm). Methods: Six randomized controlled trials (RCT) were identified by a Medline search from 2004-2013. Trial groups from 5 phase III RCTs provided data (HERA, NCCTG N9831, NSABP B31, PACS 04, and FinHER).In total, 11,200 pts were randomized in these 5 trials;4,220 of whom had ≤2cm tumors, and known number of positive axillary lymph nodes and HR status(2,588 randomized to T and 1,632 to no T). The individual pt meta-analysis will include pts with tumors ≤2 cm (T1a, T1b and T1c) and 0-1, 2-3 and ≥ 4 positive lymph nodes. Separate analyses will be performed for the two HR cohorts. This analysis will complement the published summary data-based Cochrane Review (Moja et al. 2012) by allowing a detailed investigation of the effect of disease characteristics, such as HR, on treatment effects. In addition to the standard Yusuf-Peto fixed effects model (Yusuf et al. 1985) we will investigate the impact of heterogeneity in study baseline hazards and study treatment effects by fitting random effect models.An intention to treat approach will produce a conservative effect estimate as substantial numbers of control-group pts 'crossed over' to the T arm after positive DFS results were reported. Methods to account for this ‘selective crossover’ are being developed; we plan to extend these methods to the meta-analysis setting to provide less conservative estimates. Results: Pending. Conclusions: A meta-analysis of 5 randomized adjuvant T trials focusing on pts with tumors ≤2cm will be performed and results submitted before the meeting.
Iridoid, phenylethanoid and flavonoid glycosides from Forsythia suspensa (2019)

As part of our continuing efforts to explore bioactive compounds from natural resources, a new iridoid glycoside, adoxosidic acid-6'-oleuroperic ester (<b>1</b>), together with one known phenylethanoid glycoside (<b>2</b>) and two known flavonoid glycosides (<b>3-4</b>) were isolated from the fruit of <i>Forsythia suspensa</i>. The structure of the new compound (<b>1</b>) was elucidated through 1D and 2D NMR spectroscopic data and HR-ESIMS. Interestingly, compound <b>1</b> was a monoterpene ester of one iridoid glycoside. Compounds <b>2-4</b> were identified as calceolarioside A (<b>2</b>), kaempferol-3-<i>O</i>-rutinoside (<b>3</b>), kampferol-3-<i>O</i>-robinobioside (<b>4</b>) on the basis of NMR spectroscopic data analyses and comparison with the data reported in the literature. The antiviral activity aganisist influenza A (H5N1) virus of compound <b>1</b> was studied as well.
Phosphorylated tau interactome in the human Alzheimer’s disease brain (2020)

Accumulation of phosphorylated tau is a key pathological feature of Alzheimer's disease. Phosphorylated tau accumulation causes synaptic impairment, neuronal dysfunction and formation of neurofibrillary tangles. The pathological actions of phosphorylated tau are mediated by surrounding neuronal proteins; however, a comprehensive understanding of the proteins that phosphorylated tau interacts with in Alzheimer's disease is surprisingly limited. Therefore, the aim of this study was to determine the phosphorylated tau interactome. To this end, we used two complementary proteomics approaches: (i) quantitative proteomics was performed on neurofibrillary tangles microdissected from patients with advanced Alzheimer's disease; and (ii) affinity purification-mass spectrometry was used to identify which of these proteins specifically bound to phosphorylated tau. We identified 542 proteins in neurofibrillary tangles. This included the abundant detection of many proteins known to be present in neurofibrillary tangles such as tau, ubiquitin, neurofilament proteins and apolipoprotein E. Affinity purification-mass spectrometry confirmed that 75 proteins present in neurofibrillary tangles interacted with PHF1-immunoreactive phosphorylated tau. Twenty-nine of these proteins have been previously associated with phosphorylated tau, therefore validating our proteomic approach. More importantly, 34 proteins had previously been associated with total tau, but not yet linked directly to phosphorylated tau (e.g. synaptic protein VAMP2, vacuolar-ATPase subunit ATP6V0D1); therefore, we provide new evidence that they directly interact with phosphorylated tau in Alzheimer's disease. In addition, we also identified 12 novel proteins, not previously known to be physiologically or pathologically associated with tau (e.g. RNA binding protein HNRNPA1). Network analysis showed that the phosphorylated tau interactome was enriched in proteins involved in the protein ubiquitination pathway and phagosome maturation. Importantly, we were able to pinpoint specific proteins that phosphorylated tau interacts with in these pathways for the first time, therefore providing novel potential pathogenic mechanisms that can be explored in future studies. Combined, our results reveal new potential drug targets for the treatment of tauopathies and provide insight into how phosphorylated tau mediates its toxicity in Alzheimer's disease.
Supplementary Data from Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma (2023)

Supplementary Data from Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma
4 decades of optical information processing (1991)

Get PDF Email Share Share with Facebook Share on X Post on reddit Share with LinkedIn Add to Mendeley Add to BibSonomy Share with WeChat Get Citation Copy Citation Text Joseph W. Goodman, "4 decades of optical information processing," Optics & Photonics News 2(2), 11-15 (1991) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
IFATS Collection: In Vivo Therapeutic Potential of Human Adipose Tissue Mesenchymal Stem Cells After Transplantation into Mice with Liver Injury (2008)

Mesenchymal stem cells (MSCs), largely present in the adult human body, represent an attractive tool for the establishment of a stem cell-based therapy for liver diseases. Recently, the therapeutic potential and immunomodulatory activity of MSCs have been revealed. Adipose tissue-derived mesenchymal stem cells (AT-MSCs), so-called adipose-derived stem cells or adipose stromal cells, because of their high accessibility with minimal invasiveness, are especially attractive in the context of future clinical applications. The goal of the present study was to evaluate the therapeutic potential of AT-MSCs by their transplantation into nude mice with CCl(4)-caused liver injury. We observed that after transplantation, AT-MSCs can improve liver functions, which we verified by changes in the levels of biochemical parameters. Ammonia, uric acid, glutamic-pyruvic transaminase, and glutamic-oxaloacetic transaminase concentrations returned to a nearly normal level after AT-MSC transplantation. These results raised the question of how AT-MSCs can achieve this. To discover the possible mechanisms involved in this therapeutic ability of AT-MSCs, in vitro production of cytokines and growth factors was analyzed and compared with MSCs from bone marrow (BM-MSCs) and normal human dermal fibroblasts (NHDFs). As a result we observed that AT-MSCs secrete interleukin 1 receptor alpha (IL-1Ralpha), IL-6, IL-8, granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), monocyte chemotactic protein 1, nerve growth factor, and hepatocyte growth factor in a volume higher than both BM-MSCs and NHDFs. Thus, our findings suggest that AT-MSCs may account for their broad therapeutic efficacy in animal models of liver diseases and in the clinical settings for liver disease treatment. Disclosure of potential conflicts of interest is found at the end of this article.
Gene Delivery of Cytochrome P450 Epoxygenase Ameliorates Monocrotaline-Induced Pulmonary Artery Hypertension in Rats (2010)

Pulmonary arterial hypertension (PAH) is a life-threatening disease that leads to progressive pulmonary hypertension, right heart failure, and death. Endothelial dysfunction and inflammation were implicated in the pathogenesis of PAH. Epoxyeicosatrienoic acids (EETs), products of the cytochrome P450 epoxygenase metabolism of arachidonic acid, are potent vasodilators that possess anti-inflammatory and other protective properties in endothelial cells. We investigated whether gene delivery with the human cytochrome P450 epoxygenase 2J2 (CYP2J2) ameliorates monocrotaline (MCT)-induced pulmonary hypertension in rats. Significant pulmonary hypertension developed 3 weeks after the administration of MCT, but gene therapy with CYP2J2 significantly attenuated the development of pulmonary hypertension and pulmonary vascular remodeling, without causing changes in systemic arterial pressure or heart rate. These effects were associated with increased pulmonary endothelial NO synthase (eNOS) expression and its activity, inhibition of inflammation in the lungs, and transforming growth factor (TGF)-β/type II bone morphogenetic protein receptor (BMPRII)-drosophila mothers against decapentaplegic proteins (Smads) signaling. Collectively, these data suggest that gene therapy with CYP2J2 may have potential as a novel therapeutic approach to this progressive and oftentimes lethal disorder.
Photocurrent gain in graphene-silicon p-i-n junction (2015)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text T. Gu, N. Petrone, A. van der Zande, Y. Li, A. Cheng, T. F. Heinz, P. Kim, J. Hone, C. W. Wong, C. Santori, and R. Beausoleil, "Photocurrent gain in graphene-silicon p-i-n junction," in CLEO: 2015, OSA Technical Digest (online) (Optica Publishing Group, 2015), paper SW4N.4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article