gebhart/patrepeval huggingface dataset:
Rolf Bernander (1956–2014): pioneer of the archaeal cell cycle (2014)

On 19 January 2014 Rolf ('Roffe') Bernander passed away unexpectedly. Rolf was a dedicated scientist; his research aimed at unravelling the cell biology of the archaeal domain of life, especially cell cycle-related questions, but he also made important contributions in other areas of microbiology. Rolf had a professor position in the Molecular Evolution programme at Uppsala University, Sweden for about 8 years, and in January 2013 he became chair professor at the Department of Molecular Biosciences, The Wenner-Gren Institute at Stockholm University in Sweden. Rolf was an exceptional colleague and will be deeply missed by his family and friends, and the colleagues and co-workers that he leaves behind in the scientific community. He will be remembered for his endless enthusiasm for science, his analytical mind, and his quirky sense of humour.
Chain transfer during the aqueous ring-opening metathesis polymerization of 7-oxanorbornene derivatives (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChain transfer during the aqueous ring-opening metathesis polymerization of 7-oxanorbornene derivativesMarcia B. France, Robert H. Grubbs, Dominic V. McGrath, and Rocco A. PacielloCite this: Macromolecules 1993, 26, 18, 4742–4747Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/ma00070a002https://doi.org/10.1021/ma00070a002research-articleACS PublicationsRequest reuse permissionsArticle Views611Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Power and performance optimization at the system level (2005)

The BlueGene/L supercomputer has been designed with a focus on power/performance efficiency to achieve high application performance under the thermal constraints of common data centers. To achieve this goal, emphasis was put on system solutions to engineer a power-efficient system. To exploit thread level parallelism, the BlueGene/L system can scale to 64 racks with a total of 65536 computer nodes consisting of a single compute ASIC integrating all system functions with two industry-standard PowerPC microprocessor cores in a chip multiprocessor configuration. Each PowerPC processor exploits data-level parallelism with a high-performance SIMD oating point unitTo support good application scaling on such a massive system, special emphasis was put on efficient communication primitives by including five highly optimized communification networks. After an initial introduction of the Blue-Gene/L system architecture, we analyze power/performance efficiency for the BlueGene system using performance and power characteristics for the overall system performance (as exemplified by peak performance numbers.To understand application scaling behavior, and its impact on performance and power/performance efficiency, we analyze the NAMD molecular dynamics package using the ApoA1 benchmark. We find that even for strong scaling problems, BlueGene/L systems can deliver superior performance scaling and deliver significant power/performance efficiency. Application benchmark power/performance scaling for the voltage-invariant energy delay 2 power/performance metric demonstrates that choosing a power-efficient 700MHz embedded PowerPC processor core and relying on application parallelism was the right decision to build a powerful, and power/performance efficient system
Bio-inspired gas sensing: boosting performance with sensor optimization guided by “machine learning” (2020)

The performance of existing gas sensors often degrades in field conditions because of the loss of measurement accuracy in the presence of interferences. Thus, new sensing approaches are required with improved sensor selectivity. We are developing a new generation of gas sensors, known as multivariable sensors, that have several independent responses for multi-gas detection with a single sensor. In this study, we analyze the capabilities of natural and fabricated photonic three-dimensional (3-D) nanostructures as sensors for the detection of different gaseous species, such as vapors and non-condensable gases. We employed bare Morpho butterfly wing scales to control their gas selectivity with different illumination angles. Next, we chemically functionalized Morpho butterfly wing scales with a fluorinated silane to boost the response of these nanostructures to the vapors of interest and to suppress the response to ambient humidity. Further, we followed our previously developed design rules for sensing nanostructures and fabricated bioinspired inorganic 3-D nanostructures to achieve functionality beyond natural Morpho scales. These fabricated nanostructures have embedded catalytically active gold nanoparticles to operate at high temperatures of ≈300 °C for the detection of gases for solid oxide fuel cell (SOFC) applications. Our performance advances in the detection of multiple gaseous species with specific nanostructure designs were achieved by coupling the spectral responses of these nanostructures with machine learning (a.k.a. multivariate analysis, chemometrics) tools. Our newly acquired knowledge from studies of these natural and fabricated inorganic nanostructures coupled with machine learning data analytics allowed us to advance our design rules for sensing nanostructures toward the required gas selectivity for numerous gas monitoring scenarios at room and high temperatures for industrial, environmental, and other applications.
Pig Models of Reproduction (2017)

This chapter highlights literature evidencing the benefits and use of pigs in areas of human reproduction. In swine and human oocytes, germinal vesicle breakdown occurs after about 20 h; however, in mice this occurs within a few hours. While there is parallelism of meiotic stages between porcine and human oocytes, they also share an increase in meiotic abnormalities. In mouse oocytes, the main cause of fertilization failure is unsuccessful spermatozoa penetration, while the majority of fertilization failure in human and pig oocytes is a consequence of oocyte cytoplasm insufficiency to support pronuclear formation. The pig placenta is an epitheliochorial diffuse type being less invasive of the maternal system than the hemochorial discoid-type placenta of humans that deeply decidualizes the uterus. The timing of puberty after exposure to endocrine disrupting signals from environmental and dietary toxins was also previously modeled in swine.
LaCo1–xNixO3 with Improved Electrical Conductivity (2012)

To determine the applicability of LaCo(1-x)Ni(x)O(3) in a conductive material for electrical wiring, the dependence of the electronic transport property on the Ni content is investigated via Hall effect measurements, Rietveld analyses, and band-structure calculations. Ni doping (50 mol %) into the Co sites realizes a high electrical conductivity of 1.9 × 10(3) S/cm, which is an unexpectedly high value for a LaCo(1-x)Ni(x)O(3) system, at room temperature due to the high carrier concentration of 2.2 × 10(22) cm(-3) and the small effective mass of 0.1 m(e). In addition, the high electrical conductivity is maintained from room temperature to 900 °C; that is, the temperature coefficient of the conductivity is smaller than that of standard metals. Thus, the results indicate that LaCo(0.5)Ni(0.5)O(3) is suitable as a conductive material for electrical wiring at high temperatures in air.
Chronic Evaluation of a Clinical System for Deep Brain Stimulation and Recording of Neural Network Activity (2013)

These results provide further insight into mechanisms of DBS therapy for epilepsy and an encouraging demonstration of the capabilities of this new technology, which in the future, may afford unique opportunities to study human brain function and neuromodulation mechanism of action.
A New Classification of Thoracolumbar Injuries (2005)

Although there will always be limitations to any cataloging system, the TLICS reflects accepted features cited in the literature important in predicting spinal stability, future deformity, and progressive neurologic compromise. This classification system is intended to be easy to apply and to facilitate clinical decision-making as a practical alternative to cumbersome classification systems already in use. The TLICS may improve communication between spine trauma physicians and the education of residents and fellows. Further studies are underway to determine the reliability and validity of this tool.
Optical requirements and modelling of coupling devices for the SAFARI instrument on SPICA (2011)

The next generation of space missions targeting far-infrared bands will require large-format arrays of extremely low-noise detectors. The development of Transition Edge Sensors (TES) array technology seems to be a viable solution for future mm-wave to Far-Infrared (FIR) space applications where low noise and high sensitivity is required. In this paper we concentrate on a key element for a high sensitivity TES detector array, that of the optical coupling between the incoming electromagnetic field and the phonon system of the suspended membrane. An intermediate solution between free space coupling and a single moded horn is where over-moded light pipes are used to concentrate energy onto multi-moded absorbers. We present a comparison of modelling techniques to analyse the optical efficiency of such light pipes and their interaction with the front end optics and detector cavity.
Detailed Study of Attached and Separated Compression Corner Flowfields in High Reynolds Number Supersonic Flow (1979)

An experimental study has been carried out to detail the interaction of a compressible turbulent boundary layer with shock waves of varying strengths. The interaction was produced by two-dimension al compression corners of 8, 16, 20, and 24 deg angles. The incoming boundary layer had an edge Mach number of 2.85 and a Reynolds number of 1.7 million based on overall thickness. Detailed mean flow and surface measurements are presented for the four corner angles. The 8 deg corner flow was found to be fully attached, while the 16 deg case was near incipient separation. Both the 20 and 24 deg corners produced significant flow separation regions. In the discussion of these results, emphasis is placed on the development of flowfield properties from attached to separated conditions. Comparisons made with a computational solution of the Navier-Stokes equations show good agreement when the corner flow is not separated. Separated corner flows seem to require a more complex turbulence model in the computational solution.
Coherence of Sound and Understanding Where it is Influenced in the Ocean (2013)

Abstract : The objective of this research is to develop software that accurately quantifies the spatial regions that influence the propagation of sound between a source and receiver in the ocean. Recent studies indicate that in some circumstances accurate predictions of temporal coherence can be made without knowing where the sound is being influenced (Spiesberger, 2011a,b). The present study will develop software to map where the sound is being influenced. Understanding where the sound is influenced will make it easier for scientists to develop theories to predict coherence. At very high acoustic frequencies, the regions that influence sound are shown by rays. Our research will develop software that shows the analogy of the ray path at all finite frequencies. Even moderately high frequencies are influenced by regions that are quite different than ray paths (Spiesberger, 2006b).
Full Integration and Electrical Characterization of 3D Silicon Interposer Demonstrator Incorporating High Density TSVs and Interconnects (2012)

Silicon interposers with TSVs appear to open new possibilities thanks to high wiring density interconnections and improved electrical performances given by shorter interconnections from die to die and also from die to substrate. Silicon interposers are also promising in terms of high reliability interconnections for large chips due to minimized CTE mismatch compared to standard organic substrates. A silicon interposer including high density TSVs has been successfully processed and fully tested. Process integration has been characterized, electrical results have been analyzed and they will be discussed in this paper. The first half of this paper will focus on integration including several technical challenges such as: 10:1 Aspect Ratio dense TSV of 10μm diameter, damascene metal layers 100,000 25μm diameter micro-bumps per die, and a specific backside redistribution layer, and the electrical data from DC tests achieved after full realization of the silicon interposer. These results show very high yield and a good uniformity among wafers. The later half of this paper will focus on assembly process and reliability test. Conventional mass reflow was performed for each level assembly. As assembly was successfully processed, reliability test which were TC 1000 cycles to check electrical connection on daisy chain and C4 bump, HTS for 1000 hours to observe resistance change on C4 bump and HAST 1000hours to check underfill delamination was performed. All samples passed each reliability test. The results in detail will be discussed in this paper.
Cardiac Resynchronization Therapy in Patients With Permanent Atrial Fibrillation (2012)

Patients with permanent atrial fibrillation who are otherwise CRT candidates appear to gain minimal benefit from CRT-ICD compared with a standard ICD.
Session details: Device modeling and simulation - part 1 (2007)

No abstract available.
Switching surface chemistry with supramolecular machines. (2005)

Tethered supramolecular machines represent a new class of active self-assembled monolayers in which molecular configurations can be reversibly programmed using electrochemical stimuli. We are using these machines to address the chemistry of substrate surfaces for integrated microfluidic systems. Interactions between the tethered tetracationic cyclophane host cyclobis(paraquat-p-phenylene) and dissolved {pi}-electron-rich guest molecules, such as tetrathiafulvalene, have been reversibly switched by oxidative electrochemistry. The results demonstrate that surface-bound supramolecular machines can be programmed to adsorb or release appropriately designed solution species for manipulating surface chemistry.
Experimental Study Into Vortex Induced Motion Response of Semi Submersibles With Square Columns (2008)

Vortex Induced Motion (VIM) of a Deep Draft Semi® with four square columns has been observed in model tests and in a prototype configuration. The flow field around the columns causes the vessel to oscillate along one of the vessel’s main diagonals under particular conditions. The observations and conclusions of three series of VIM model programs are combined in this report. Each test program was executed with a unique objective in mind and each setup was unique. Many similarities in response characteristics have been identified. Some of the differences in observed response are identified and discussed. A discussion is provided regarding the scaling of VIM problems, and the importance of the Reynolds number under model test conditions is discussed. The VIM of a typical Gulf of Mexico Deep Draft Semi® may affect the fatigue life of the mooring system and risers. A formulation is developed that predicts the distribution of VIM amplitudes which then can be used to estimate VIM induced fatigue damage. Observations and conclusions are provided of several experiments where VIM response was evaluated in the presence of a fatigue sea state and for a system with increased sway damping.
2,4‐Disubstituted Pyrimidines: A Novel Class of KDR Kinase Inhibitors. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Pharmacological Investigation of Observed Anxiolytic Effects of the Marine Natural Product Aaptamine (2008)

Aaptamine, 8,9-dimethoxy-4H-benzo[de][1,6]naphthyridine, is isolated in significant amounts from the marine sponge Aaptos sp. and exhibits broad activity against a number of in vitro receptors and whole cell targets [1]. The benzonapthyridine core is unique in nature and contains structural characteristics of dopamine. This structural characteristic corresponds to recently reported data that claims anti-depressant effects of aaptamine in mouse forced swim tests [2]. Aaptamine was administered in three doses (5, 10, 15 mg/kg i.m.) and the mice were observed for anxiolytic effects in an established chick social separation-stress model [3]. Results showed that separation-induced distress vocalizations were significantly attenuated in isolated chicks receiving 10 or 15 mg/kg aaptamine (ns = 12; ps < 0.05). However, higher concentrations of aaptamine were reported to induce a transient sedative state followed by motor incoordination. Thus the anxiolytic effects reported at the lower doses may be related to aaptamine's other behavioral effects. In an effort to identify receptor system(s) mediating this behavior, aaptamine was tested for its ability to compete for µ-, δ- and κ-opioid receptor binding (vs. 3H-DAMGO, 3H-DPDPE and 3H–U69593 respectively) in rat brain membranes. The results of receptor binding assays indicated low affinity of aaptamine for all three opioid receptors with Ki values 1.49 ± 0.07 µM for µ- and > 5 µM for δ- and κ-opioid receptors. Acknowledgements: The project described was supported by Grant Number P20RR021929 from the National Center For Research Resources. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Research Resources or the National Institutes of Health. This investigation was conducted in a facility constructed with support from research facilities improvement program C06 RR-14503-01 from the NIH National Center for Research Resources. References: [1] Bowling J, et al. (2008) Chem. Biol. Drug Disc. (Epub) [2] Diers J, et al. (2007) Pharmacol Biochem Behav. (Epub) [3] Feltenstein M, et al. (2004) Pharmacol Biochem Behav. 77(2): 221–6.
Protecting genomic data analytics in the cloud: state of the art and opportunities (2016)

Abstract The outsourcing of genomic data into public cloud computing settings raises concerns over privacy and security. Significant advancements in secure computation methods have emerged over the past several years, but such techniques need to be rigorously evaluated for their ability to support the analysis of human genomic data in an efficient and cost-effective manner. With respect to public cloud environments, there are concerns about the inadvertent exposure of human genomic data to unauthorized users. In analyses involving multiple institutions, there is additional concern about data being used beyond agreed research scope and being prcoessed in untrused computational environments, which may not satisfy institutional policies. To systematically investigate these issues, the NIH-funded National Center for Biomedical Computing iDASH (integrating Data for Analysis, â anonymizationâ and SHaring) hosted the second Critical Assessment of Data Privacy and Protection competition to assess the capacity of cryptographic technologies for protecting computation over human genomes in the cloud and promoting cross-institutional collaboration. Data scientists were challenged to design and engineer practical algorithms for secure outsourcing of genome computation tasks in working software, whereby analyses are performed only on encrypted data. They were also challenged to develop approaches to enable secure collaboration on data from genomic studies generated by multiple organizations (e.g., medical centers) to jointly compute aggregate statistics without sharing individual-level records. The results of the competition indicated that secure computation techniques can enable comparative analysis of human genomes, but greater efficiency (in terms of compute time and memory utilization) are needed before they are sufficiently practical for real world environments.
Composite pressure cell for pulsed magnets (2021)

Extreme pressures and high magnetic fields can affect materials in profound and fascinating ways. However, large pressures and fields are often mutually incompatible; the rapidly changing fields provided by pulsed magnets induce eddy currents in the metallic components used in conventional pressure cells, causing serious heating, forces, and vibration. Here, we report a diamond-anvil-cell made mainly out of insulating composites that minimizes inductive heating while retaining sufficient strength to apply pressures of up to 8 GPa. Any residual metallic component is made of low-conductivity metals and patterned to reduce eddy currents. The simple design enables rapid sample or pressure changes, desired by pulsed-magnetic-field-facility users. The pressure cell has been used in pulsed magnetic fields of up to 65 T with no noticeable heating at cryogenic temperatures. Several measurement techniques are possible inside the cell at temperatures as low as 500 mK.
Characterization of petroleum biodegradation patterns in weathered contaminated soils (1995)

Two soils were contaminated by petroleum, then allowed to weather for 2 years. The soils were then subjected to bioremediation using static systems, flow through columns, and slurry systems, each with and without nutrient addition. Petroleum in the static system degraded more slowly and less completely, whereas the slurry system was bet. In all systems, the fractions represented by gas chromatograph (GC) elution times from 0 to 10 and 10 to 15 min were rapidly degraded. However, for compounds that eluted at greater than 15 min, the slurry system was superior to the column system and little degradation of these materials was evident in the static units.