gebhart/patrepeval huggingface dataset:
Supplementary Tables 4 and 5 from Rationale and Preclinical Efficacy of a Novel Anti-EMP2 Antibody for the Treatment of Invasive Breast Cancer (2023)

&lt;p&gt;PDF - 64K, Supplementary Table 4. Evaluation of EMP2 IgG1 toxicity compared to control IgG following 7 weeks of treatment delivered systemically IP. Supplementary Table 5. Evaluation of EMP2 IgG1 toxicity compared to control IgG following systemic IP treatment of up to 40mg/kg.&lt;/p&gt;
Heat Removal for Adsorbed Natural Gas Storage: Lab to Industrial Scale (2020)

The objective of this paper is to present different possible scenarios of heat removal for adsorbed natural gas storage (ANG) technology applied to diurnal peak shaving in connection with the gas pipeline system. Efficient removal of heat generated by adsorption is essential for fully utilizing the designed storage capacity of an adsorber vessel in such technology. To address this issue, adsorption isotherm data is collected using a lab-scale adsorber, with a volume of 120 cm3. Then, an adsorption isothermal model was developed based on the adsorption potential theory. Isosteric heat of adsorption and integral heat of adsorption were calculated as the base of the internal heat generation rate during the adsorption process. The temperature profile of the adsorber bed at the end of the charging process was simulated using a cylindrical coordinate system to mimic an ANG adsorber vessel having the length of 15 m and the diameter of 1.42 m (pipeline with 56 in. diameter). The results showed that improved thermal conductivity of adsorbents combined with a cooling jacket (e.g., central tube or cooling coil) can achieve 95% or more of the designed storage capacity. Our results demonstrated that ANG is an industrially applicable technology for diurnal peak shaving.
Real-time tracking of fluorescent magnetic spore–based microrobots for remote detection of C. diff toxins (2019)

A rapid, direct, and low-cost method for detecting bacterial toxins associated with common gastrointestinal diseases remains a great challenge despite numerous studies and clinical assays. Motion-based detection through tracking the emerging micro- and nanorobots has shown great potential in chemo- and biosensing due to accelerated "chemistry on the move". Here, we described the use of fluorescent magnetic spore-based microrobots (FMSMs) as a highly efficient mobile sensing platform for the detection of toxins secreted by <i>Clostridium difficile</i> (<i>C. diff</i>) that were present in patients' stool. These microrobots were synthesized rapidly and inexpensively by the direct deposition of magnetic nanoparticles and the subsequent encapsulation of sensing probes on the porous natural spores. Because of the cooperation effect of natural spore, magnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles, and functionalized carbon nanodots, selective fluorescence detection of the prepared FMSMs is demonstrated in <i>C. diff</i> bacterial supernatant and even in actual clinical stool samples from infectious patients within tens of minutes, suggesting rapid response and good selectivity and sensitivity of FMSMs toward <i>C. diff</i> toxins.
Skin friction measurements by laser interferometry in swept shock/boundary-layer interactions (1990)

Measurements have been made of wall shear stresses in swept interactions of planar shock waves generated by a sharp fin and the two-dimensional turbulent boundary layer on a flat plate. Test conditions were Mach number 3.03, Reynolds number Ree - 1.5 X 104, wall temperature near adiabatic, and fin angles of 10 and 16 deg. Measurements were made using the Laser Interferometer Skin Friction (LISF) meter, which optically detects the thickness of an oil film on the test surface. The results show that such measurements are practical in high-speed interacting flows with a repeatability of ± 12% or better. Further, with proper data handling, LISF measurements appear feasible at very high shear levels, which were previously considered unobtainable. Dramatic increases in wall shear were observed in both swept interactions tested. These data are compared with computational Navier-Stokes solutions by Horstman and Knight wherein k-e and algebraic turbulence models were used. Both computations predict the overall measured c/ levels at a = 10 deg but fail to predict some features of the Cf distributions properly.
Thermoplastic matrix‐based composites produced by resin transfer molding: A review (2022)

Abstract The recycling of thermoset‐based composites is challenging. The replacement of thermosetting resins with thermoplastics is an initial step to address this issue, together with the use of green reinforcements. Owing to the recent development of low‐viscosity thermoplastic resins, it is possible to produce thermoplastic matrix composites using the resin transfer molding (RTM) technique, which was originally conceived for the production of thermosetting matrix composites. These resins are based on cyclic esters, methyl methacrylate, and cyclic (butylene terephthalate) oligomers. This review presents the state‐of‐the‐art works reported on the production of thermoplastic matrix composites via a thermoplastic RTM (TP‐RTM) process, from the in situ polymerization of the resins through the optimization of the TP‐RTM parameters for the evaluation of the composite properties.
A (Z)-ethylidenecyclopentane annulation method. Total syntheses of (.+-.)-anhydrooplopanone, (.+-.)-oplopanone, and (.+-.)-8-epi-oplopanone (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA (Z)-ethylidenecyclopentane annulation method. Total syntheses of (.+-.)-anhydrooplopanone, (.+-.)-oplopanone, and (.+-.)-8-epi-oplopanoneEdward Piers and Ashvinikumar V. GavaiCite this: J. Org. Chem. 1990, 55, 8, 2380–2390Publication Date (Print):April 1, 1990Publication History Published online1 May 2002Published inissue 1 April 1990https://pubs.acs.org/doi/10.1021/jo00295a028https://doi.org/10.1021/jo00295a028research-articleACS PublicationsRequest reuse permissionsArticle Views718Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Pseudocoordination, Serial Verb Constructions and Multi-Verb Predicates: The relationship between form and structure (2021)

What is pseudocoordination? What are the implications for syntactic theory? This dissertation approaches these questions from the perspective of linguistic typology and syntactic theory. Verbal pseudocoordination like <em>go and get</em> or <em>try and do</em> is an under-studied phenomenon even in English but especially in languages around the world. In some ways resembling coordination, in others subordination, the mixed properties of these constructions introduce substantive questions for language comparison and theoretical analysis, given the variety of ways in which languages render similar structural relationships and dependencies.<br> This dissertation makes three broad contributions to linguistic research. First, the results of a worldwide, balanced sample of 325 languages, as well as smaller samples of creoles and signed languages, provide the distribution and typology of pseudocoordination, serial verb and other multi-verb constructions, supplemented by the appendix listing these features for each language and a comprehensive bibliography; these features are also studied in relation to the cross-linguistic expression of Associated Motion. Second, the unusual morphosyntactic restrictions of the English <em>try and</em> construction are documented in detail, along with parallels in Faroese, and shown to require augmented methods for syntactic analysis. Third, the diversity of multi-verb constructions and other theoretically challenging constructions support the proposal of an approach to syntactic theory mixing insights from Generative Grammar and Construction Grammar. [See attached document for complete abstract.] This is the original version of the document, as deposited with the university for degree. This version is also available at the University of Illinois Urbana-Champaign institutional repository here: http://hdl.handle.net/2142/113888 Updates to this project are planned and will be posted here on Zenodo. For that reason, please cite this work with the "concept" DOI https://doi.org/10.5281/zenodo.5546425, which will always redirect to the newest version, if citing the work in general. If, however, you are citing specific pages or including quotations, then the DOI specific to this version, https://doi.org/10.5281/zenodo.5546426, would be appropriate. Example citation format: Ross, Daniel. 2021. Pseudocoordination, Serial Verb Constructions and Multi-Verb Predicates: The relationship between form and structure. University of Illinois Urbana-Champaign Ph.D. dissertation. https://doi.org/10.5281/zenodo.5546425 I welcome feedback from other researchers related to any of the topics discussed in this dissertation. Please see my website http://danielrosslinguist.com for contact information and more information about my research. For an online bibliography of pseudocoordination corresponding to the references in this dissertation, see http://pseudocoordination.com
High Glass Transition Temperature Syndioregic Second Order Nonlinear Optical Polymers in Langmuir-Blodgett-Kuhn Films (1997)

Recent progress has been made toward the goal of processing polymers at low temperature to produce all-polymeric nonlinear optical films which may ultimately find application as active waveguides. Our previously reported work [1] has utilized the Langmuir-Blodgett-Kuhn (LBK) technique to produce such films but the noncentrosymmetric order in those films was lost when heated above 80 °C. New polymers were designed to yield ordered films with higher thermal stability by eliminating the long alkyl side chains (Figure 1). The glass transition temperature (Tg) of the bulk polymer is about 240 °C, and the upper limit on short term thermal baking stability is about 320 °C [2].
A novel protein‐based prognostic signature improves risk stratification to guide clinical management in early‐stage lung adenocarcinoma patients (2018)

Each of the pathological stages (I-IIIa) of surgically resected non-small-cell lung cancer has hidden biological heterogeneity, manifested as heterogeneous outcomes within each stage. Thus, the finding of robust and precise molecular classifiers with which to assess individual patient risk is an unmet medical need. Here, we identified and validated the clinical utility of a new prognostic signature based on three proteins (BRCA1, QKI, and SLC2A1) to stratify early-stage lung adenocarcinoma patients according to their risk of recurrence or death. Patients were staged according to the new International Association for the Study of Lung Cancer (IASLC) staging criteria (8th edition, 2018). A test cohort (n = 239) was used to assess the value of this new prognostic index (PI) based on the three proteins. The prognostic signature was developed by Cox regression with the use of stringent statistical criteria (TRIPOD: Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis). The model resulted in a highly significant predictor of 5-year outcome for disease-free survival (p < 0.001) and overall survival (p < 0.001). The prognostic ability of the model was externally validated in an independent multi-institutional cohort of patients (n = 114, p = 0.021). We also demonstrated that this molecular classifier adds relevant information to the gold standard TNM-based pathological staging, with a highly significant improvement of the likelihood ratio. We subsequently developed a combined PI including both the molecular and the pathological data that improved the risk stratification in both cohorts (p ≤ 0.001). Moreover, the signature may help to select stage I-IIA patients who might benefit from adjuvant chemotherapy. In summary, this protein-based signature accurately identifies those patients with a high risk of recurrence and death, and adds further prognostic information to the TNM-based clinical staging, even when the new IASLC 8th edition staging criteria are applied. More importantly, it may be a valuable tool for selecting patients for adjuvant therapy. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Through-space interactions between parallel-offset arenes at the van der Waals distance: 1,8-diarylbiphenylene syntheses, structure and QM computations (2008)

A model for studying polar-pi interactions between arenes spaced at van der Waals distances is developed on the basis of peri-diarylbiphenylenes. A set of 1,8-diarylbiphenylenes is synthesized comprising two Hammett series, one with reference to mesityl ring interactions and the other with reference to pentafluorophenyl ring interactions. X-Ray crystal structures of several derivatives are determined. Barriers to rotation of the probe aryl ring are derived from dynamic NMR data and show a trend for the mesityl reference series (DeltaG(not equal) vs. sigma(0)). The model is also used as a test for comparison of modern density functional methods, including B3LYP, M06-2X and BMK functionals; dispersive effects are seen to be an important factor in the proper theoretical treatment of arene interactions.
Kinetics of the end of range damage dissolution in flash-assist rapid thermal processing (2006)

This study investigates the effectiveness of flash-assist rapid thermal processing in dissolving the end of range damage inherent to preamorphizing implants. A series of silicon wafers is preamorphized with a Ge implant and subsequently implanted with B. The wafers are then subjected to a flash anneal, a rapid thermal anneal, or both annealing processes. The flash anneal results in higher defect densities and trapped interstitials than the rapid thermal anneal. Defect dissolution has been previously reported to have an activation energy between 4 and 5eV. This work demonstrates that the defect dissolution during flash-assist rapid thermal processing is mediated by a 2.2±0.05eV activation energy.
DDS and Me (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Selective olefin dimerization via tantallocyclopentane complexes (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelective olefin dimerization via tantallocyclopentane complexesS. J. McLain and R. R. SchrockCite this: J. Am. Chem. Soc. 1978, 100, 4, 1315–1317Publication Date (Print):February 1, 1978Publication History Published online1 May 2002Published inissue 1 February 1978https://pubs.acs.org/doi/10.1021/ja00472a060https://doi.org/10.1021/ja00472a060research-articleACS PublicationsRequest reuse permissionsArticle Views313Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cigarette smoke-exposed neutrophils die unconventionally but are rapidly phagocytosed by macrophages (2011)

Pulmonary accumulation of neutrophils is typical for active smokers who are also predisposed to multiple inflammatory and infectious lung diseases. We show that human neutrophil exposure to cigarette smoke extract (CSE) leads to an atypical cell death sharing features of apoptosis, autophagy and necrosis. Accumulation of tar-like substances in autophagosomes is also apparent. Before detection of established cell death markers, CSE-treated neutrophils are effectively recognized and non-phlogistically phagocytosed by monocyte-derived macrophages. Blockade of LOX-1 and scavenger receptor A, but not MARCO or CD36, as well as pre-incubation with oxLDL, inhibited phagocytosis, suggesting that oxLDL-like structures are major phagocytosis signals. Specific lipid (β-carotene and quercetin), but not aqueous, antioxidants increased the pro-phagocytic effects of CSE. In contrast to non-phlogistic phagocytosis, degranulation of secondary granules, as monitored by lactoferrin release, was apparent on CSE exposure, which is likely to promote pulmonary inflammation and tissue degradation. Furthermore, CSE-exposed neutrophils exhibited a compromised ability to ingest the respiratory pathogen, Staphylococcus aureus, which likely contributes to bacterial persistence in the lungs of smokers and is likely to promote further pulmonary recruitment of neutrophils. These data provide mechanistic insight into the lack of accumulation of apoptotic neutrophil populations in the lungs of smokers and their increased susceptibility to degradative pulmonary diseases and bacterial infections.
Enhancement of cancer invasion and growth via the C5a‑C5a receptor system: Implications for cancer promotion by autoimmune diseases and association with cervical cancer invasion (2018)

Autoimmune diseases are caused by immune complex-induced activation of the complement system and subsequent inflammation. Recent studies have revealed an association between autoimmune diseases and worse survival in patients with cancer; however, the underlying mechanism is still unknown. The C5a-C5a receptor (C5aR) system has been shown to enhance cancer activity and recruit myeloid-derived suppressor cells (MDSCs) that suppress the anti-tumor immune response. The Arthus reaction is inflammation caused by complement system activation by the immune complex and thus is a model of autoimmune diseases. To explore the effect of the Arthus reaction on cancer progression, mouse cancer cells were inoculated in syngeneic mouse skin, where the Arthus reaction was induced simultaneously. The Arthus reaction enhanced invasion and tumor growth of C5aR-positive cancer cells, but not control cells, and induced MDSC recruitment. Intravenous injection of C5a-stimulated C5aR-positive cancer cells into nude mice resulted in more lung nodules than injection of nontreated C5aR-positive cells and C5a-stimulated C5aR-negative cells, supporting C5a-C5aR-mediated enhancement of cancer growth. C5aR expression in uterine cervical carcinoma stage I cells, which invade into the deeper tissues, was significantly higher than that in CIN3 cells, which remain in the epithelium. These results indicate that cancer promotion by the C5a-C5aR system may underlie poor prognosis in cancer patients with autoimmune diseases, particularly in patients with C5aR-positive cancer, and may be associated with cervical cancer invasion. The enhancement of cancer cell invasion and growth by the C5a-C5aR system suggests that this system is a possible target of cancer therapy.
Norfolk QOL‐DN: validation of a patient reported outcome measure in transthyretin familial amyloid polyneuropathy (2014)

The Norfolk Quality of Life-Diabetic Neuropathy (QOL-DN) questionnaire is an instrument to assess QOL in diabetic polyneuropathy. The objective of this observational, cross-sectional study in 61 patients with V30M transthyretin familial amyloid polyneuropathy (TTR-FAP) and 16 healthy volunteers was to validate the Norfolk QOL-DN for assessment of QOL in TTR-FAP. Comparisons were conducted to identify the best items to discriminate disease stages and assess which individual Norfolk domains (symptoms, large fiber, small fiber, autonomic, and activities of daily living) would be most affected by disease stage. Analysis of individual items revealed a significant pattern of discrimination among disease stages (p < 0.001). Total QOL scores increased (indicating worsening) with duration of symptoms, with a steeper increase observed earlier in the course of disease. Significant correlations were observed between each Norfolk domain and other measures of neurological function. Limitations include cross-sectional study design, low patient numbers in this rare disease, and the ordinal-based character of the metric used; future areas to explore include item response theory approaches such as Rasch analysis. These results suggest the Norfolk QOL-DN is a reliable indicator of the impact of disease severity on QOL in patients with TTR-FAP.
Detection and characterization of Hepatitis E virus from commercial rabbit livers in Hebei, China (2021)

Rabbit hepatitis E virus (HEV) has been reported for years and is thought to have the potential for zoonotic transmission from rabbits to humans. As reported, HEV genotype 3 (gt3) is the most prevalent form of HEV in rabbits. To determine the prevalence of HEV in commercial rabbit livers, 176 liver samples were collected from an abattoir in Hebei Province, China. Three (1.7%) samples tested positive for RNA of HEV-ORF2 (open reading frames-2). Sequence analysis showed that the three isolates shared high identities with each other (94.08–98.85%). Further analysis showed that all the rabbit strains clustered together in the branch of HEV gt3. Further study by immunohistochemistry (IHC) assays showed that 131 (74.4%) liver samples were positive for HEV ORF2 protein. Pathological changes including cell degeneration, inflammatory cell infiltration and bile duct epithelial cell hyperplasia were observed under microscopy. These findings indicated the presence of HEV in commercial livers of rabbits. Additional studies should be conducted to investigate the infectivity of rabbit HEV (rHEV) and the potential risks of zoonotic transmission of rHEV from rabbits to human beings.
ChemInform Abstract: β‐Lactams by a Nickel Powder/Acetic Acid Mediated Radical Cyclization. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Confusion and altered behaviour? Cause (2013)

We describe the case of a 65-year-old man who presented with confusion and change in behaviour, and describe the investigative steps that were taken before a diagnosis was made. This patient was eventually diagnosed with leptomeningeal carcinomatosis secondary to a previously undiagnosed oesophageal carcinoma.