gebhart/patrepeval huggingface dataset:
Comparative Study of Microfabricated Inductors/Transformers for High-Frequency Power Applications (2017)

This paper presents a comparative study on different microfabricated inductors (microtransformers), which are suitable for high-frequency power application. The main topic of this study is comparing and analyzing the effect of some factors such as material type, number of turns, and coil form on microinductor performance considering a fixed chip size, fixed magnetic core size, and core form. Two different microtransformer designs with different magnetic core materials are considered in this work. The core materials used in this work are NiFe45/55 and CoFe45/55. Also, two types of device packages are developed, namely, Quad Flat No-Lead and FR4 embedded packages. For device testing, different high-frequency switching regulators available on the market are used. This study shows the influence of different parameters on the performance of a certain high-frequency application. In this paper, we discuss the influence of the design, magnetic material, and package type on thermal performance and the efficiency of the power application.
Experimental-Numerical Comparison for a High-Density Data Center: Hot Spot Heat Fluxes in Excess of 500 W/FT2 (2006)

The current trend of using denser server environments is continuously increasing to satisfy the growing needs of e-commerce and other emerging technologies. The resulting high room-level heat fluxes present significant challenges with respect to maintaining acceptable computer rack inlet temperatures and minimizing total data center energy consumption. Numerical methods are widely used to model existing and new facilities. Validation of existing numerical techniques is an important step in facilitating good thermal design of data centers. This paper uses previously published experimental data to present a comparison between test results and numerical simulations. The example considered is a large 7400 ft <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> data canter that houses over 130 heat-producing racks (1.2 MW) and 12 air conditioning units. Localized hot spot heat fluxes were measured to be as high as 512 W/ft <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> (5.5 kW/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) for a 400 ft (37 m) region. A numerical model based on computational fluid dynamics (CFD) was constructed using inputs from the measurements. The rack inlet air temperature was considered to be the basis for experimental vs. numerical comparison. The overall mean rack inlet temperature predicted numerically at a height of 1.75 m is within 4degC of the test data with a rack-by-rack standard deviation of 3.3 degC
Novels clean methodology to improve GOI performance of high voltage device (2004)

Dual gate technology is widely used on high voltage products. Therefore, the treatment on dual gate oxide loop is very critical. Unfortunately, some troubles happened at dual gate oxide loop process. Photoresist peeling and poor uniformity on LV gate oxide thickness were the major troubles on this loop. The intention of this report is to provide an optimized clean procedure at dual gate oxide loop for 0.35 HV device and improves GOI performance.
Does fibrin clot really enhance graft healing after double‐bundle ACL reconstruction in a caprine model? (2014)

The use of fibrin clot in ACL reconstruction in a caprine model demonstrated improved healing with respect to histological analysis of the intra-articular ACL reconstruction segment and decreased signal intensity on MRI. It may lead to improved graft healing and maturation. By accelerating the intra-articular healing and ligamentization, the outcome of patients after ACL-R can be improved with faster return to sports and daily activity.
Multi-product resource planning (2002)

This paper presents a line balancing method concerning the assembly of a family of products. The product variants are assembled following different assembly sequences (some operations are different or missing). The problem is to assign each operation to a workstation in order to meet production requirements at the minimum total system cost. Operations are assigned to workstations in such a way that: (1) no assembly precedence constraint of the family product is violated; (2) no workstation in the line takes on average longer than a predefined cycle time to perform all the tasks assigned to it; and (3) as few workstations as possible are needed to perform all the tasks in the set. A grouping genetic algorithm approach used to solve the single-product assembly line balancing (ALE) problem has been modified to handle the multi-product ALE problem. The result is a Multi-Product Resource Planner. Industrial tests are presented and confirm the efficiency of the proposed algorithm.
Abstract 19386: Adaptive Upregulation of MicroRNA-146b Following Surgical Ischemia-Reperfusion Attenuates Myocardial Inflammation (2012)

Introduction: Using a comparative biology approach we prioritized microRNAs (miRs) deregulated by surgical myocardial I/R. We hypothesized that in vitro overexpression of miR-146b is cardioprotective following simulated I/R through attenuation of NF-kB mediated inflammation. Finally, we compared two delivery methods of miR modulators - chemical transfection versus nanoparticle-bound. Methods: 1) miR expression analysis - microarray of myocardium from 2 models of I/R: a) rats - cardioplegic arrest (CA) or deep hypothermic circulatory arrest (DHCA) and 24h reperfusion, or sham; 2 rat strains with different susceptibilities to myocardial I/R used - Brown Norway (BN) and Dahl Salt Sensitive (DSS); b) pigs - CA or DHCA and 6h reperfusion, or sham (N=4/group). Deregulated miRs (FDR &lt;0.1) validated by qPCR. 2) miR-146b functional analysis- ARVCs transfected with miR-146b mimics or inhibitors, subjected to 2h OGD - 6h reoxygenation; target gene expression IRAK1 and TRAF6 qPCR and Western; necrosis and apoptosis assays. 3) Nanoparticle delivery - chemical or nanoparticle-mediated ARVC transfection monitored as above plus Cy3-miR. Nanoparticle-bound Cy3-miR administered to rats in cardioplegia; biodistribution by fluorescence microscopy. Results: Robust post I/R miR-146b upregulation conserved across species, experimental conditions, and reperfusion timepoints (Fig, A). Different miR-146b expression between rat strains (BN vs DSS) corresponded to severity of myocardial injury. miR-146b overexpression attenuated IRAK 1, TRAF6 and NF-kB p65 upregulation following simulated I/R (Fig, B), resulting in improved cardiomyocyte viability (Fig, C). Nanoparticles show superior transfection efficiency to chemical methods in vitro, and early extravascular myocardial distribution. Conclusion: miR-146b may exert inhibitory feedback on NF-kB activation through effects on key regulatory elements IRAK1 and TRAF6 with potential cardioprotective roles.
StoryBank (2007)

This paper considers information access styles for a community digital library in an Indian village. We present our impressions of the community gathered during a field-study and show how these have influenced the interaction design. The prototype aims to overcome low-textual literacy and lack of computing experience by combining touch-based interaction, engaging visual presentations and drawing on villagers' familiarity with radio listening.
Web Service Composition : Semantic Links based Approach (2008)

Pr. Claude Godart Reviewer. University Henri Poincare, Nancy, France Dr. Marco Pistore Reviewer. Fondazione Bruno Kessler, Trento, Italy Dr. Biplav Srivastava Reviewer. IBM’s T.J.Watson Research, Center in Hawthorne, NY, USA Dr. Bernd Amann Examiner. University Pierre and Marie Curie (LIP6), Paris, France. Jury: Dr. Fabien Gandon Examiner. INRIA’s Research Center, Sophia-Antipolis, France. Pr. Mohand-Said Hacid Examiner. University Claude Bernard (LIRIS), Lyon, France Pr. Olivier Boissier Co-Advisor. Ecole Nationale Superieure des Mines, Saint-Etienne, France. Dr. Alexandre Delteil Co-Advisor. Orange Labs, Issy, France. Dr. Alain Leger Co-Advisor. Orange Labs, Rennes, France.
Immune Dysfunction and Bacterial Coinfections following Influenza (2013)

Secondary pulmonary infections by encapsulated bacteria including Streptococcus pneumoniae and Staphylococcus aureus following influenza represent a common and challenging clinical problem. The reasons for this polymicrobial synergy are still not completely understood, hampering development of effective prophylactic and therapeutic interventions. Although it has been commonly thought that viral-induced epithelial cell damage allows bacterial invasiveness, recent studies by several groups have now implicated dysfunctional innate immune defenses following influenza as the primary culprit for enhanced susceptibility to secondary bacterial infections. Understanding the immunological imbalances that are responsible for virus/bacteria synergy will ultimately allow the design of effective, broad-spectrum therapeutic approaches for prevention of enhanced susceptibility to these pathogens.
Ten year experience of an integrated cancer prevention center screening for multiple cancer types. (2017)

1549 Background: Cancer is the leading cause of mortality worldwide. Prevention and early detection are pivotal tools for reducing cancer burden. Methods: We describe the 10 year experience (2006-2016) of an integrated cancer prevention center that provides screening for prevention and early detection of 11 most common cancer types. Healthy individuals (20-80 yr) were included. Extensive clinical and epidemiological data was obtained. DNA was extracted from all participants and genotyped for APC I1307K and E1317Q. Patients were examined by specialists in internal medicine, surgery, plastic surgery, OBGYN, urology, oncology, oral surgery, gastroenterology, and others. Women underwent vaginal US and pap smear and (40yr) mammography and US/MRI with a clinical indication. PSA and free PSA for Men ( &gt; 40yr). LDCT for heavy smokers. Colonoscopy was recommended to all subjects ( &gt; 40yr). Results: A total of 6258 (49%) men and 6461 (51%) women mean age 47.0±11.5 year were screened. New malignant lesions were detected in 389 (1.75%) of screeners. The most common cancers were of skin (74, 0.6%), prostate (62, 0.5%), thyroid (51, 0.4%), breast (36, 0.3%), colorectal (22, 0.2%), ovarian (19, 0.1%), uterus (14, 0.1%), testis (12, 0.09%) urinary (9, 0.07%) and lung (10, 0.08%). In 28 patients (0.22%) more than one cancer was detected. Twenty eight of the cancer patients (7.2%) died after 32.4±28.1 months at a mean age of 69.4±14.2 years. Significantly, better than the expected cancer mortality. The APC I1307K and E1317Q variants were detected in 572 (4.8%) and 182 (1.5%) subjects respectively. First degree family member with cancer (OR = 2.02), I1307K carrier ship (OR = 1.53), female gender (OR = 1.23) and advanced age (OR = 1.06) were all associated with statistically significant (P &lt; 0.05) increased cancer risk. Advanced age and first degree family history were also associated with detection of more than one cancer types. Conclusions: One stop shop screening, in the setting of a multidisciplinary outpatient clinic, is feasible and can prevent and detect cancer at an early stage. It significantly improve morbidity and mortality. Impressively the APC I1307K carries an overall increase cancer risk.
Bifidobacterium breve with α-Linolenic Acid and Linoleic Acid Alters Fatty Acid Metabolism in the Maternal Separation Model of Irritable Bowel Syndrome (2012)

The aim of this study was to compare the impact of dietary supplementation with a Bifidobacterium breve strain together with linoleic acid & a-linolenic acid, for 7 weeks, on colonic sensitivity and fatty acid metabolism in rats. Maternally separated and non-maternally separated Sprague Dawley rats (n = 15) were orally gavaged with either B. breve DPC6330 (10 9 microorganisms/day) alone or in combination with 0.5% (w/w) linoleic acid & 0.5% (w/w) a-linolenic acid, daily for 7 weeks and compared with trehalose and bovine serum albumin. Tissue fatty acid composition was assessed by gas-liquid chromatography and visceral hypersensitivity was assessed by colorectal distension. Significant differences in the fatty acid profiles of the non-separated controls and maternally separated controls were observed for a-linolenic acid and arachidonic acid in the liver, oleic acid and eicosenoic acid (c11) in adipose tissue, and for palmitoleic acid and docosahexaenoic acid in serum (p,0.05). Administration of B. breve DPC6330 to MS rats significantly increased palmitoleic acid, arachidonic acid and docosahexaenoic acid in the liver, eicosenoic acid (c11) in adipose tissue and palmitoleic acid in the prefrontal cortex (p,0.05), whereas feeding B. breve DPC6330 to non separated rats significantly increased eicosapentaenoic acid and docosapentaenoic acid in serum (p,0.05) compared with the NS un-supplemented controls. Administration of B. breve DPC6330 in combination with linoleic acid and a-linolenic acid to maternally separated rats significantly increased docosapentaenoic acid in the serum (p,0.01) and a-linolenic acid in adipose tissue (p,0.001), whereas feeding B. breve DPC6330 with fatty acid supplementation to non-separated rats significantly increased liver and serum docosapentaenoic acid (p,0.05), and a-linolenic acid in adipose tissue (p,0.001). B. breve DPC6330 influenced host fatty acid metabolism. Administration of B. breve DPC6330 to maternally separated rats significantly modified the palmitoleic acid, arachidonic acid and docosahexaenoic acid contents in tissues. The effect was not observed in non-separated animals.
Microbial Hydroxylation of Hydroxyprogesterones and α-Glucosidase Inhibition Activity of Their Metabolites (2007)

Microbial transformation of 11α-hydroxyprogesterone (1) with Cunninghamella elegans, Gibberella fujikuroi, Fusarium lini, and Candida albicans yielded 11α,15α,16α-trihydroxypregn-4- ene-3,20-dione (3), 11α-hydroxy-5α-pregnane-3,20-dione (4), 6β ,11α-dihydroxypregn-4-ene-3,20- dione (5), 11α-hydroxypregna-1,4-diene-3,20-dione (6), 11α,17β -dihydroxyandrost-4-en-3-one (7), and 11α,15α-dihydroxypregn-4-ene-3,20-dione (8). On the other hand, microbial transformation of 17α-hydroxyprogesterone (2) with Cunninghamella elegans and Fusarium lini yielded 11α,17α- dihydroxypregn-4-ene-3,20-dione (9), and 17α-hydroxypregna-1,4-diene-3,20-dione (10). The structures of the metabolites 3 - 10 were deduced on the basis of spectroscopic methods. Compound 3 was identified as a new metabolite, which exhibited a promising inhibitory activity against the α-glucosidase enzyme.
A new monocyclic fluropolymer structure for 157-nm photoresists (2004)

We earlier developed a series of fluoropolymers (FPRs) for use as first-generation 157-nm photoresist polymers. These FPRs have a partially fluorinated monocyclic structure and provide excellent transparency. However, their etching resistance is low (half that of conventional KrF resists) and an insufficient dissolution rate in tetramethylammonium hydroxide (TMAH) solution. To improve the characteristics of these polymers, while retaining high transparency, we had to redesign the main chain fluoropolymer structure. In this paper, we describe a new monocyclic fluoropolymer structure for a second-generation 157-nm photoresist polymer. This structure also has a fluorine atom in the polymer main chain, as well as a fluoro-containing acidic alcohol group. We synthesized two types of fluoropolymers, ASF-1 and ASF-2. We found that ASF-1 had transparency of 0.18 &#956;m<sup>-1</sup>, better than that of the FPRs, and the etching resistance was improved. Unfortunately, the dissolution rate was poor. On the other hand, ASF-2 showed even better transparency of 0.1 &#956;m<sup>-1</sup>, improved etching resistance, and a dissolution rate of more than 600 nm/s, which is sufficient for use as a resist. The introduction of a protecting group (e.g., the methoxymethyl or adamantylmethoxymethyl group) to the hydroxyl group of ASF-2 can be done after the polymerization reaction. Using partially protected ASF-2 with an appropriate protecting group, we were able to fabricate a sub-60-nm line-and-space pattern.
Nonclinical Development of Biologics: Integrating Safety, Pharmacokinetics, and Pharmacodynamics to Create Smarter and More Flexible Nonclinical Safety Programs Optimizing Animal Use (2021)

Safety assessment of biological drugs has its challenges due to the multiple new different modalities, for example, antibody-drug conjugates, bispecifics, nanobodies, fusion proteins and advanced therapy medicinal products (ATMPs), their different pharmacokinetic and pharmacodynamic properties, and their ability to trigger immunogenicity and toxicity. In the public and in the pharmaceutical industry, there is a strong and general desire to reduce the number of animals used in research and development of drugs and in particular reducing the use of nonhuman primates. Important discussions and activities are ongoing investigating the smarter designs of early research and dose range finding studies, reuse of animals, and replacing animal experiments with in vitro studies. Other important challenges include absence of a relevant species and design of studies and developing genetically modified animals for special investigative toxicology studies. Then, the learnings and challenges from the development of the first ATMPs are available providing valuable insights in the development path for these new potentially transformative treatments. Finally, development of strategies for assessment of immunogenicity and prediction of translation of immunogenicity and associated findings to the clinic. On this, the eighth meeting for the European BioSafe members, these challenges served as the basis for the presentations and discussions during the meeting. This article serves as the workshop report reviewing the presentations and discussions at the meeting.
Applications of Artificial Intelligence for Static Poisson’s Ratio Prediction While Drilling (2021)

The prediction of continued profile for static Poisson's ratio is quite expensive and requires huge experimental works, and the discontinuity in the measurement and the limited applicability and accuracy of the present empirical correlations necessitated the utilization of artificial intelligence with its prosperous application in oil and gas industry. This work aims to construct different artificial intelligence models for predicting static Poisson's ratio of complex lithology at real time during drilling. The functional networks (FN) and random forest (RF) approaches were utilized using the mechanical drilling parameters as inputs. This study uses a vertical well with 1775 records from complex lithology containing shale, sand, and carbonate for model building. Besides, a different dataset from another well was used to check the models' validity. The results demonstrated that both FN- and RF-based models predicted static Poisson's ratio with significant matching accuracy. The FN technique results' correlation coefficient (<i>R</i>) value of 0.89 and average absolute percentage error (AAPE) values of 10.23% and 10.28% in training and testing processes. While the RF technique is outperformed, as illustrated by the highest <i>R</i> values of 0.99 and 0.94 and the lowest AAPE values of 1.89% and 5.19% for training and testing processes, the robustness and reliability of the developed models were confirmed in the validation process with <i>R</i> values of 0.94 and 0.86 and AAPE values of 11.23% and 5.12% for FN- and RF-based models, respectively. The constructed models developed a basis for inexpensive static Poisson's ratio prediction in real time with significant accuracy.
InAs Planar Diode Fabricated by Zn Diffusion (2000)

An InAs planar diode with an optical window in the upper electrode was fabricated by the selective diffusion of Zn. Diethylzinc (DEZn) was used as a precursor for Zn and the diffusion process was carried out in a metalorganic chemical vapor deposition (MOCVD) system containing tertiary butylarsine (tBAs) as an As precursor to suppress the thermal decomposition of InAs. Typical diffusion conditions were: temperature 530°C, time 30 min, pressure of DEZn and tBAs 1.0 Pa and 75 Pa, respectively, and ambient pressure 40 kPa. Electrical characteristics of the diode were excellent: the ideality factor was as small as 1.05 for forward-biased current–voltage characteristics at 200 K and the reverse current was less than 10 -8 A at 80 K. The peak photosensitivity at 175 K was 0.28 A/W around 3.2 µm in wavelength without antireflection coating. When the diode was driven at 150 mA at 80 K, two mid-infrared emission peaks were observed at 3.04 µm and 3.25 µm.
Fabrication of Interference Textures on Cemented Carbides Using Nanosecond and Femtosecond Laser Pulses (2020)

Laser surface texturing is becoming popular in recent years, as its application in variant fields can bring in many benefits, such as to improve tribological performances of contact surfaces. As frontline engineering materials, cemented carbides are widely used in mining and manufacturing. Using as cutting tool materials, it is then interesting to texture the working surfaces of cemented carbides. In this work, a cemented tungsten carbide grade is selected as target material. Line-like structures are produced on the surfaces of the cemented carbide grade by the method of direct laser interference patterning (DLIP) using nanosecond and femtosecond laser pulses, respectively. Specific laser setup is individually configured to obtain topographic features on the scale of micrometer. It is aimed to testify the production precision using such configuration and compare the ablation effects using the two typical laser set-ups. Topographic features of the produced patterns are characterized using confocal laser scanning microscopy. Morphological features and surface integrity are inspected by scanning electron microscopy also using a focused ion beam. It is found that both nano- and femtosecond lasers achieved satisfactory geometrical precision, which comply with the theoretical calculation. The surface formed by the femtosecond laser is cleaner and shows smoother patterns exhibiting lower melting or microcrack formation.
Enhancing Energy Efficiency in LTE with Antenna Muting (2012)

The concept of antenna muting for reducing energy consumption in LTE is presented and system level evaluation results are provided. The results indicate that antenna muting can reduce the energy consumption with up to around 50% in a low load scenario without significantly affecting the user throughput. Results for 4TX, 2TX, and 1TX cell configurations are presented. The system level simulator used includes detailed models of UE pre-coder selection and feedback and we show in this paper that these algorithms performs well also when antennas are muted in a way that was not considered during the design of the algorithms. Antenna muting is a promising technique that operates on a rather short time scale in order to reduce the energy consumption of an LTE cell.
Multimodel adaptive ℋ/sub ∞/ control (2002)

We formulate and solve a multimodel /spl Hscr//sub /spl infin// adaptive control problem. In this problem, the unknown plant is one of a finite number of possible models. The control objective is to find an adaptive (possibly nonlinear and time-varying) controller that achieves an /spl Hscr//sub /spl infin// bound on the closed-loop transfer function for all possible plants. We present an exact solution for the optimal adaptive controller in two cases: (a) the plants are static, but possibly nonlinear, functions, and (b) the plants are linear time-invariant (LTI).