gebhart/patrepeval huggingface dataset:
2-[(4-Phenylpiperazin-1-yl)methyl]imidazo(di)azines as Selective D4-Ligands. Induction of Penile Erection by 2-[4-(2-Methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a Potent and Selective D4Partial Agonist (2006)

A series of novel 2-[(4-phenylpiperazin-1-yl)methyl]imidazoazines and aza-analogues were prepared and screened at selected dopamine, serotonin, and adrenergic receptor subtypes. 2-Substituted imidazopyridines and pyridazines presented high affinities and selectivities for D4 dopamine receptors. Whereas functional experiments indicated neutral antagonists or weak partial agonist effects for most of the target compounds, the 2-methoxyphenyl substituted 2-piperazinylmethylimidazopyridine 3c (PIP3EA) displayed substantial agonist efficacy in mitogenesis experiments and GTPgammaS binding tests, resulting in EC50 values of 3.0 (46%) and 4.5 nM (57%), respectively. Our D4 agonist 3c induced penile erection in vivo when administered to rats. This effect was inhibited by L-745,870 a D4 selective antagonist, confirming the mechanistic pathway.
THREE-DIMENISONAL MONOCULAR SCENE RECONSTRUCTION FOR SERVICE-ROBOTS - An Application (2007)

This paper presents an image based three dimensional reconstruction system for service-robot applications in case of daily table scenarios. Image driven environment perception is one of the main research topics in the field of autonomous robot applications and fundamental for further action-plannings like three dimensional collision detection and prevention for grasping tasks. Perception will be done at two spatial-temporal varying positions by a micro-head camera mounted on a six-degree-of-freedom robot-arm of our mobile service-robot TASER. The epipolar geometry and fundamentalmatrix will be computed by preliminary extracted corners of both input images detected by a Harris-cornerdetector. The input images will be rectified using the fundamentalmatrix to align corresponding scanlines together on the same vertical image coordinates. Afterwards a stereo correspondence is accomplished by a fast Birchfield algorithm that provides a 2.5 dimensional depth map of the scene. Based on the depth map a three dimensional textured point-cloud is represented as interactive OpenGL scene model for further actionplanning algorithms in three dimensional space.
Specific RNA-protein interactions detected with saturation transfer difference NMR (2013)

RNA, at the forefront of biochemical research due to its central role in biology, is recognized by proteins through various mechanisms. Analysis of the RNA-protein interface provides insight into the recognition determinants and function. As such, there is a demand for developing new methods to characterize RNA-protein interactions. Saturation transfer difference (STD) NMR can identify binding ligands for proteins in a rather short period of time, with data acquisitions of just a few hours. Two RNA-protein systems involved in RNA modification were studied using STD NMR. The N (6)-threonylcarbamoyltransferase, YrdC, with nucleoside-specific recognition, was shown to bind the anticodon stem-loop of tRNA(Lys)UUU. The points of contact on the RNA were assigned and a binding interface was identified. STD NMR was also applied to the interaction of the archaeal ribosomal protein, L7Ae, with the box C/D K-turn RNA. The distinctiveness of the two RNA-protein interfaces was evident. Both RNAs exhibited strong STD signals indicative of direct contact with the respective protein, but reflected the nature of recognition. Characterization of nucleic acid recognition determinants traditionally involves cost and time prohibitive methods. This approach offers significant insight into interaction interfaces fairly rapidly, and complements existing structural methods.
Development of extraction and optimization based large-signal models for thinned metamorphic high-electron mobility transistors on germanium (2002)

HEMTs on germanium have the advantage that the substrate can be easily removed, which facilitates integration into low-cost MCM-D circuit implementations. Although germanium has (dispersive) characteristics similar to silicon, we show that the large-signal modeling of these thinned Ge based metamorphic high-electron mobility transistors (HEMTs) is similar to that of GaAs and InP HEMTs. Two types of look-up table based nonlinear models that are respectively based on direct extraction and optimization are developed and evaluated. © 2002 Wiley Periodicals, Inc. Int J RF and Microwave CAE 12, 439–447, 2002. Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mmce10042
Ferritin Nanocages with Biologically Orthogonal Conjugation for Vascular Targeting and Imaging (2018)

Genetic incorporation of biologically orthogonal functional groups into macromolecules has the potential to yield efficient, controlled, reproducible, site-specific conjugation of affinity ligands, contrast agents, or therapeutic cargoes. Here, we applied this approach to ferritin, a ubiquitous iron-storage protein that self-assembles into multimeric nanocages with remarkable stability, size uniformity (12 nm), and endogenous capacity for loading and transport of a variety of inorganic and organic cargoes. The unnatural amino acid, 4-azidophenylalanine (4-AzF), was incorporated at different sites in the human ferritin light chain (hFTL) to allow site-specific conjugation of alkyne-containing small molecules or affinity ligands to the exterior surface of the nanocage. The optimal positioning of the 4-AzF residue was evaluated by screening a library of variants for the efficiency of copper-free click conjugation. One of the engineered ferritins, hFTL-5X, was found to accommodate ∼14 small-molecule fluorophores (AlexaFluor 488) and 3-4 IgG molecules per nanocage. Intravascular injection in mice of radiolabeled hFTL-5X carrying antibody to cell adhesion molecule ICAM-1, but not control IgG, enabled specific targeting to the lung due to high basal expression of ICAM-1 (43.3 ± 6.99 vs 3.48 ± 0.14%ID/g for Ab vs IgG). Treatment of mice with endotoxin known to stimulate inflammatory ICAM-1 overexpression resulted in 2-fold enhancement of pulmonary targeting (84.4 ± 12.89 vs 43.3 ± 6.99%ID/g). Likewise, injection of fluorescent, ICAM-targeted hFTL-5X nanocages revealed the effect of endotoxin by enhancement of near-infrared signal, indicating potential utility of this approach for both vascular targeting and imaging.
Design of an Ecological Flow-based Interface for 4D Trajectory Management in Air Traffic Control (2015)

The concept of trajectory-based operations as proposed by SESAR and NextGen seeks to increase airspace efficiency and capacity by introducing time as an explicit control variable. Such form of operations lean heavily on the introduction of higher levels of automation to support the human air traffic controller in performing this new task. In previous research, and following the ecological interface design paradigm, a constraint-based decision support tool has been developed to visualize safe and unsafe fields of travel for rerouting the 4D trajectories of individual aircraft. A human-in-the-loop experiment showed that although the interface visualizes the boundaries between safe and unsafe actions, the quality of control in terms of robustness was mainly dependent on the level of expertise of the human controller. Following these findings, the goal of this study has been twofold: 1) to explicitly integrate the attributes of robust control actions into the constraint-based visualization, and 2) to enable flow-based (multi-aircraft) operations with the decision-support tool which is more in line with the mental model of expert controllers. As a result, a metric for the evaluation of robustness has been developed and three different types of structure-based control abstractions have been identified which have been integrated into the tool. Future work will focus on a human-in-the-loop experiment in order to evaluate the effectiveness of these two new additions.
Relation between Comfortability and Motion of the Floating Traffic Terminal at Minato Mirai 21 (1993)

A new type of traffic terminal has been constructed at Yokohama bay recently. It is composed of 2-storied house on a floating pontoon and moored by pile-fender system. There are ticket counter and waiting lounge on the first floor and restaurant on the second floor. Since the floating type was applied to the passengers terminal station for the first time in Japan, We examined the relation between comfortability and motion of the terminal. Several interesting results, such as people who are easy to get seasick have tendency to estimate the motion of the structure excessively, are obtained.
Optical Measurement of Partial Discharge Propagation Phenomena including Leader Transition in SF<sub>6</sub> Gas (2021)

This paper described optical phenomena of propagating partial discharges (PDs) including leader transition from streamer discharge in SF6 gas under positive and negative standard lightning impulse voltage. The optical measurement was performed using by special optical instruments like a framing camera composing of three ICCD cameras with optical filters to obtain spatial- or time-resolved spectroscopic images, a streak camera for a streak image or streak spectrum with a spectroscope, and a phot-multiplier tube (PMT) for light emission intensity, together with PD current and applied voltage waveform measurement by controlling the gate timing of the framing and streak cameras. As a result, typical optical properties to understand the leader transition based on stem or precursor mechanism were clarified, and optical features to identify the streamer and the leader discharge as well as the precursor that has not yet led to leader transition were found. These new findings could contribute to better understanding of PD mechanism as well as improvement of PD diagnostics of gas-insulated switchgear.
National Neuroinformatics Framework for Canadian Consortium on Neurodegeneration in Aging (CCNA) (2018)

The Canadian Institutes for Health Research (CIHR) launched the "International Collaborative Research Strategy for Alzheimer's Disease" as a signature initiative, focusing on Alzheimer's Disease (AD) and related neurodegenerative disorders (NDDs). The Canadian Consortium for Neurodegeneration and Aging (CCNA) was subsequently established to coordinate and strengthen Canadian research on AD and NDDs. To facilitate this research, CCNA uses LORIS, a modular data management system that integrates acquisition, storage, curation, and dissemination across multiple modalities. Through an unprecedented national collaboration studying various groups of dementia-related diagnoses, CCNA aims to investigate and develop proactive treatment strategies to improve disease prognosis and quality of life of those affected. However, this constitutes a unique technical undertaking, as heterogeneous data collected from sites across Canada must be uniformly organized, stored, and processed in a consistent manner. Currently clinical, neuropsychological, imaging, genomic, and biospecimen data for 509 CCNA subjects have been uploaded to LORIS. In addition, data validation is handled through a number of quality control (QC) measures such as double data entry (DDE), conflict flagging and resolution, imaging protocol checks, and visual imaging quality validation. Site coordinators are also notified of incidental findings found in MRI reads or biosample analyses. Data is then disseminated to CCNA researchers via a web-based Data-Querying Tool (DQT). This paper will detail the wide array of capabilities handled by LORIS for CCNA, aiming to provide the necessary neuroinformatic infrastructure for this nation-wide investigation of healthy and diseased aging.
Computational memory-based inference and training of deep neural networks (2019)

In-memory computing is an emerging computing paradigm where certain computational tasks are performed in place in a computational memory unit by exploiting the physical attributes of the memory devices. Here, we present an overview of the application of in-memory computing in deep learning, a branch of machine learning that has significantly contributed to the recent explosive growth in artificial intelligence. The methodology for both inference and training of deep neural networks is presented along with experimental results using phase-change memory (PCM) devices.
Laterally scaled Si-Si/sub 0.7/Ge/sub 0.3/ n-MODFETs with f/sub max/>200 GHz and low operating bias (2005)

We report on the dc and RF characterization of laterally scaled, Si-SiGe n-MODFETs. Devices with gate length, L/sub g/, of 80 nm had f/sub T/=79 GHz and f/sub max/=212 GHz, while devices with L/sub g/=70 nm had f/sub T/ as high as 92 GHz. The MODFETs displayed enhanced f/sub T/ at reduced drain-to-source voltage, V/sub ds/, compared to Si MOSFETs with similar f/sub T/ at high V/sub ds/.
Risk theory based on-line power system security assessment (2008)

Power system is approaching its limits due to the deregulation of power industry and unavailability of new transmission corridor. However power system security assessment is carried out and the operating limits are set according to the given contingency list which might happen in very rare frequency. In other words, the frequency of fault occurrence and the risk of blackout is varied when the operating condition (load level, status of power equipment, and weather) changes. How can we do the security assessment based on the operating condition to get the best equilibrium between the security and the profit is the focus of this paper. The idea of risk based on-line power system security assessment is suggested. A precise calculation method of average failure rates of components is presented. Besides, operating condition based failure rates of components are also analyzed systematically in the paper. The Monte-Carlo simulation demonstrates the viewpoint of the paper.
Detection of Textured Areas in Images Using a Disorganization Indicator Based on Component Counts (2007)

texture detection, texture analysis, texture synthesis, image analysis An algorithm is presented for the detection of textured areas in digital images. Texture detection has potential application to image enhancement, tone correction, defect detection, content classification and image segmentation. For example, texture detection may be combined with a color model and other descriptors to detect objects in an image, such as sky, which is generally smooth, and foliage, which is textured.
Envelope delta-sigma-modulated voltage-mode class-S PA (2012)

This paper reports on a digital transmitter architecture for the 450 MHz band using an envelope delta-sigma modulator realized in CMOS and a voltage-mode class-S PA based on GaN MMICs. The class-S PA is characterized with narrowband single-tone signals and a single-carrier downlink WCDMA signal with a peak-to-average power ratio of 7.5 dB. Using single-tone excitation the PA shows a maximum drain efficiency of 86% and a peak output power of 4.4 W. At 6 dB and 10 dB back-off, 59% and 36% efficiency are achieved, respectively. With the WCDMA input signal a maximum drain efficiency of 64% and an output power of 0.7 W is reached. The ACLR shows values of about -34 dBc (5 MHz) and -38 dBc (10 MHz). This is the first complete voltage-mode class-S PA chain characterized with standard communication signals.
Inter-sequence error concealment for diversity reception of digital TV sequences (2009)

In this paper a new technique for error concealment of digital TV signals in a diversity reception scenario is proposed. Inter-sequence error concealment utilizes one or more reference sequences to reconstruct lost image blocks or slices of a video sequence. Based on the general approach of image combination for uncompressed video sequences, inter-sequence error concealment of coded TV sequences is evaluated in detail. The presented technique especially considers error propagation by motion-compensated prediction in hybrid video coding. The algorithm for error concealment is introduced on example of DVB-T signals which are transmitted in multi-frequency networks. In practice, applications like multi-standard-reception of DVB-T, DVB-H and T-DMB seem also natural.
Materials Research for GHz Multi-Chip Modules (1993)

The goal of this program is to investigate new dielectrics, metals and processes for the fabrication and characterization of multi-chip modules (MCM) which hold the promise of excellent performance, cost and yield for high frequency MCMs. First, the processes for using noble metals (gold and silver) as the interconnection metallization in the module have been investigated. Noble metal process can have fewer processing steps (particularly for gold) than the equivalent copper process and are potentially lower cost, particularly when high reliability is important. The silver process has been developed so that the silver maintains its bulk conductivity (highest of conventional metals) and has low residual stress during high temperature processing. The commercialization of the silver process is being considered. Second, a unique adhesion material has been investigated and is currently being investigated for commercial use. We are in the process of evaluating the process and with n-Chip and transferring the technology to them.
Dimetal Linked Open Frameworks:  [(CH3)4N]2(Ag2,Cu2)Ge4S10 (1996)

Synthetic and X-ray structural details, optical and vibrational spectroscopic, and thermal properties of the materials [(CH3)4N]2M2Ge4S10 (where M = Cu, Ag), are described for the first time. Rietveld PXRD full-profile structure refinements of [(CH3)4N]2M2Ge4S10 reveal a novel open-framework architecture in which dimetal M22+ and adamantanoid Ge4S104- building blocks are alternately substituted into the tetrahedral Zn2+ and S2- sites of a zinc blende lattice, all linked together by [Ge(μ-S)]2M−M[(μ-S)Ge]2 metal−metal bonded bridging units. The metal−metal distances in the S2M−MS2 “twisted I” dihedral unit are 2.761 Å (Ag) and 2.409 Å (Cu). These internuclear separations are shorter than the bulk metals themselves (2.89 Å, Ag; 2.54 Å, Cu). This implies that the adamantanoid Ge4S104--based open-framework structure is held together by d10−d10 M+−M+ metal−metal bonds. FT-Raman provides a direct probe of this interaction. Dimetal-framework breathing vibrational modes are observed around 38 cm-1 for M = Ag and 55 cm-1 for M = Cu. In situ VT-PXRD analysis demonstrates that [(CH3)4N]2Ag2Ge4S10 retains its structural integrity upon exposure to air after in vacuo heating above the [(CH3)4N]+ loss temperature. It seems likely that the disilver connection of adamantanoid Ge4S104- building blocks confers thermal stability upon the framework.
Wastewater TreatmentVery Important PaperHighly Selective Removal of Perfluorinated Contaminants byAdsorption on All-Silica Zeolite Beta (2020)

International audience
Estimation of regional surface CO2fluxes with GOSAT observations using two inverse modeling approaches (2012)

Inverse estimation of surface C0<sub>2</sub> fluxes is performed with atmospheric transport model using ground-based and GOSAT observations. The NIES-retrieved C0<sub>2</sub> column mixing (X<sub>c02</sub>) and column averaging kernel are provided by GOSAT Level 2 product v. 2.0 and PPDF-DOAS method. Monthly mean C0<sub>2</sub> fluxes for 64 regions are estimated together with a global mean offset between GOSAT data and ground-based data. We used the fixed-lag Kalman filter to infer monthly fluxes for 42 sub-continental terrestrial regions and 22 oceanic basins. We estimate fluxes and compare results obtained by two inverse modeling approaches. In basic approach adopted in GOSAT Level4 product v. 2.01, we use aggregation of the GOSAT observations into monthly mean over 5x5 degree grids, fluxes are estimated independently for each region, and NIES atmospheric transport model is used for forward simulation. In the alternative method, the model-observation misfit is estimated for each observation separately and fluxes are spatially correlated using EOF analysis of the simulated flux variability similar to geostatistical approach, while transport simulation is enhanced by coupling with a Lagrangian transport model Flexpart. Both methods use using the same set of prior fluxes and region maps. Daily net ecosystem exchange (NEE) is predicted by the Vegetation Integrative Simulator for Trace gases (VISIT) optimized to match seasonal cycle of the atmospheric C0<sub>2</sub> . Monthly ocean-atmosphere C0<sub>2</sub> fluxes are produced with an ocean pC02 data assimilation system. Biomass burning fluxes were provided by the Global Fire Emissions Database (GFED); and monthly fossil fuel C0<sub>2</sub> emissions are estimated with ODIAC inventory. The results of analyzing one year of the GOSAT data suggest that when both GOSAT and ground-based data are used together, fluxes in tropical and other remote regions with lower associated uncertainties are obtained than in the analysis using only ground-based data. With version 2.0 of L2 X<sub>c02</sub> the fluxes appear reasonable for many regions and seasons, however there is a need for improving the L2 bias correction, data filtering and the inverse modeling method to reduce estimated flux anomalies visible in some areas. We also observe that application of spatial flux correlations with EOF­ based approach reduces flux anomalies.
Memory CD4+CD45RO+SAMHD1low Cells Exhibit Distinct Genes Profile and Contain the Highest Level of HIV-1 DNA With Segregated HIV-1 Populations (2018)

Author(s): Hani, Lylia; Chaillon, Antoine; Nere, Marie-Laure; Hocini, Hakim; Lefebvre, Cecile; Ruffin, Nicolas; Becavin, Christophe; Smith, Davey M; Lelievre, Jean-Daniel; Delaugerre, Constance; Levy, Yves; Seddiki, Nabila
Portable photo system for Haag-Streit–type slitlamps (2010)

A new camera system is described that, when attached to an existing Haag-Streit-type slitlamp, can provide the photographic needs of the general ophthalmologist or optometrist conveniently and at relatively low cost. It can also be used to economically expand photography in a teaching environment. This photographic documentation is particularly beneficial when integrated into an electronic health record.
Protein labeling and biotinylation of peptides during spot synthesis using biotin p‐nitrophenyl ester (biotin‐ONp) (2008)

Biotin-labeled peptides are used for numerous biochemical and microbiological applications. Due to the strong affinity of biotin to streptavidin, the detection of biotinylated molecules is very sensitive. A powerful technique for parallel synthesis and high-throughput screening of peptides is the spot synthesis. One example for the use of spot synthesis is the screening of biotinylated peptides synthesized on cellulose membranes, which is particularly favorable for the investigation of protease cleavage sites. Additionally, in combination with biotinylated protein samples, the spot technique can be used for investigations of peptide-protein and protein-protein interactions. Here, we present our results of the use biotin p-nitrophenyl ester (biotin-ONp) in spot synthesis and as a reagent for biotin-labeling of protein samples.
Soft-Chemistry–Based Routes to Epitaxial α-Quartz Thin Films with Tunable Textures (2013)

Piezoelectric nanostructured quartz films of high resonance frequencies are needed for microelectronic devices; however, synthesis methods have been frustrated by the inhomogeneous crystal growth, crystal twinning, and loss of nanofeatures upon crystallization. We report the epitaxial growth of nanostructured polycrystalline quartz films on silicon [Si(100)] substrates via the solution deposition and gelation of amorphous silica thin films, followed by thermal treatment. Key to the process is the combined use of either a strontium (Sr(2+)) or barium (Ba(2+)) catalyst with an amphiphilic molecular template. The silica nanostructure constructed by cooperative self-assembly permits homogeneous distribution of the cations, which are responsible for the crystallization of quartz. The low mismatch between the silicon and α-quartz cell parameters selects this particular polymorph, inducing epitaxial growth.