gebhart/patrepeval huggingface dataset:
Functional Imaging of Oxidative Stress with a Novel PET Imaging Agent, 18F-5-Fluoro-l-Aminosuberic Acid (2014)

(18)F-FASu is a potentially useful metabolic tracer for PET imaging of a functional cellular response to oxidative stress. (18)F-FASu may provide more sensitive detection than (18)F-FDG in certain tumors.
Computer extracted measurements of intra-tumoral heterogeneity on H&E stained tissue images to distinguish short term and long term survivors in patients with non-small cell lung carcinoma. (2017)

e20052 Background: Molecular and morphologic heterogeneity is an important characteristic of cancer. This spatial and temporal tumor heterogeneity has important implications on tumor behavior and response to therapies. This study aims to evaluate the role of computer extracted features of intra-tumoral heterogeneity (ITH) from digitized whole slide H&amp;E stained images of early stage NSCLC patients treated with surgery as a prognostic marker for survival. Methods: A cohort of 89 early stage NSCLC patients treated with surgery with long term survival data were identified. 28 patients had OS&gt; 3 years from the date of definitive surgery and were defined as long term survivors and 61 patients had OS &lt; 3 years, and were defined as short term survivors. Corresponding H&amp;E stained whole mounted lung tissue images was digitally scanned and a thoracic pathologist marked the primary tumor margins on these images. Our computational approach involved determining the variance in measurements relating to nuclear size, shape, and texture across the tissue section; Each feature was then assigned a morphologic diversity score (MDS) based off the variance; the top predictive MDS features were identified via Wilcoxon Rank Sum Test and then evaluated via a quadratic classifier using 3-fold cross validation. Kaplan-Meier (KM) survival analysis was performed for the ITH features, as well as T- and N-stage. Results: The top ranked MDS features yielded a mean area under the receiver operating characteristic curve (AUC) of 0.66 in discriminating short term from long term survivors. A p=0.00657 (see Table) was obtained for KM-analysis of the ITH features. Conclusions: Computer extracted image features of ITH enabled differentiation of NSCLC patients with short and longer term survival. Large scale multi-site validation will need to be done to establish ITH measurements as a prognostic biomarker for NSCLC patients. [Table: see text]
Modeling and simulation of variable speed wind generator system using boost converter of permanent magnet synchronous generator (2007)

This paper proposes the variable-speed wind generator system using the boost converter. The proposed system has three speed control modes for the wind velocity. The control mode of low wind velocity regulates the armature current of the generator with the boost converter to control the windmill speed. The control mode of middle wind velocity regulates the DC link voltage with vector controlled inverter to control the windmill speed. The control mode of high wind velocity regulates the pitch angle of the wind turbine with the pitch angle control system to control the windmill speed. The hybrid of three speed control scheme extends the variable-speed range. The proposed system simplifies the maintenance, improves the reliability, and reduces the cost in compare with variable- speed wind generation system using PWM converter.
Anti‐Inflammatory Activity of Diterpenoids from Celastrus orbiculatus in Lipopolysaccharide‐Stimulated RAW264.7 Cells (2020)

Celastrus orbiculatus Thunb has been known as an ethnopharmacological medicinal plant for antitumor, anti‐inflammatory, and analgesic effects. Although various pharmacological studies of C . orbiculatus extract has been reported, an anti‐inflammatory mechanism study of their phytochemical constituents has not been fully elucidated. In this study, compounds 1 – 17 , including undescribed podocarpane‐type trinorditerpenoid ( 3 ), were purified from C . orbiculatus and their chemical structure were determined by high‐resolution electrospray ionization mass (HRESIMS) and nuclear magnetic resonance (NMR) spectroscopic data. To investigate the anti‐inflammatory activity of compounds 1 – 17 , nitric oxide (NO) secretion was evaluated in LPS‐treated murine macrophages, RAW264.7 cells. Among compounds 1 – 17 , deoxynimbidiol ( 1 ) and new trinorditerpenoid ( 3 ) showed the most potent inhibitory effects (IC 50 : 4.9 and 12.6 μ M, respectively) on lipopolysaccharide‐ (LPS‐) stimulated NO releases as well as proinflammatory mediators, such as inducible nitric oxide (iNOS), cyclooxygenase‐ (COX‐) 2, interleukin‐ (IL‐) 1 β , IL‐6, and tumor necrosis factor‐ (TNF‐) α . Its inhibitory activity of proinflammatory mediators is contributed by suppressing the activation of nuclear transcription factor‐ (NF‐) κ B and mitogen‐activated protein kinase (MAPK) signaling cascades including p65, inhibition of NF‐ κ B (I κ B), extracellular signal‐regulated kinase (ERK), c‐Jun NH 2 ‐terminal kinase (JNK), and p38. Therefore, these results demonstrated that diterpenoids 1 and 3 obtained from C . orbiculatus may be considered a potential candidate for the treatment of inflammatory diseases.
Splice-variant specific effects of a CACNA1H mutation associated with writer’s cramp (2021)

The CACNA1H gene encodes the α1 subunit of the low voltage-activated Ca<sub>v</sub>3.2 T-type calcium channel, an important regulator of neuronal excitability. Alternative mRNA splicing can generate multiple channel variants with distinct biophysical properties and expression patterns. Two major splice variants, containing or lacking exon 26 (± 26) have been found in different human tissues. In this study, we report splice variant specific effects of a Ca<sub>v</sub>3.2 mutation found in patients with autosomal dominant writer's cramp, a specific type of focal dystonia. We had previously reported that the R481C missense mutation caused a gain of function effect when expressed in Ca<sub>v</sub>3.2 (+ 26) by accelerating its recovery from inactivation. Here, we show that when the mutation is expressed in the short variant of the channel (- 26), we observe a significant increase in current density when compared to wild-type Ca<sub>v</sub>3.2 (- 26) but the effect on the recovery from inactivation is lost. Our data add to growing evidence that the functional expression of calcium channel mutations depends on which splice variant is being examined.
[POTENTIAL ANTICANCER AGENTS. I. SYNTHESIS OF DERIVATIVES OF GLUTAMINE AND RELATED COMPOUNDS]. (1963)

Twenty three glutamine derivatives (5-N-substituted amides and 5-alkylesters of phthalimido-α-aminoglutarid acid) were synthesized for anticancer and glutaminase inhibitory tests. These compounds were prepared from a-phthalimido-glutaric anhydride and appropriate amines and alcohols. The phthalyl group was removed by hydrolysis with aqueous hydrazine hydrate and sodium carbonate solution. Compound I_8 shows significant inhibitory activity against S 180 and several other animal tumors, while compounds I_(1,2,5,7-10) inhibit the activity of glutaminase. On the contrary, compounds of type II are inactive.
Area-selective atomic layer deposition of Al2O3 on SiNx with SiO2 as the nongrowth surface (2021)

Area-selective atomic layer deposition (ALD) of dielectrics on chemically similar growth and nongrowth surfaces is very challenging. In this study, we use aminosilane inhibitors to achieve selective blocking of ALD of Al2O3 on plasma-deposited SiO2 versus plasma-deposited SiNx. The SiO2 and SiNx surfaces were exposed to bis(dimethylamino)dimethylsilane followed by (N,N-dimethylamino)trimethylsilane through the vapor phase at 150 °C. At the same substrate temperature, Al2O3 films were grown by ALD using dimethylaluminum isoproxide and H2O. In situ surface infrared spectroscopy shows that aminosilane inhibitors react with almost all the surface −SiOH groups on SiO2, but reaction with surface −NHx groups on the SiNx surface is incomplete, thereby leaving potential growth sites for ALD of Al2O3. In situ ellipsometry results shows that a ∼2.7 nm Al2O3 film can be selectively deposited on SiNx versus SiO2. Upon exposure of the plasma-deposited SiNx to the atmosphere, a higher attachment of aminosilanes and longer nucleation delay during the ALD of Al2O3 were observed, indicating the need to remove the native surface oxynitride prior to functionalization. This study shows that while fully passivating the nongrowth surface is necessary for achieving growth inhibition, ALD can initiate on a partially passivated growth surface.
Radiation sensitivity of cultured human glioblastoma cells. [X radiation] (1977)

Glial cells from 2 normal brains and 9 astrocytomas were cultured in vitro. The most rapidly proliferating cell lines were obtained from Grades III-IV astrocytomas. Normal glia proliferated slowly and growth ceased after 20 to 40 generations. The response of 3 Grade III-IV lines to graded doses of radiation were determined by colony formation and end point dilution technique. Two of the 3 lines were relatively radioresistant compared to other human cell lines; this may partially account for the radiation resistance of high grade astrocytoma tumors.
Data from Loss of Neural Cell Adhesion Molecule Induces Tumor Metastasis by Up-regulating Lymphangiogenesis (2023)

&lt;div&gt;Abstract&lt;p&gt;Reduced expression of neural cell adhesion molecule (NCAM) has been implicated in the progression to tumor malignancy in cancer patients. Previously, we have shown that the loss of NCAM function causes the formation of lymph node metastasis in a transgenic mouse model of pancreatic β cell carcinogenesis (Rip1Tag2). Here we show that tumors of NCAM-deficient Rip1Tag2 transgenic mice exhibit up-regulated expression of the lymphangiogenic factors vascular endothelial growth factor (VEGF)-C and -D (17% in wild-type &lt;i&gt;versus&lt;/i&gt; 60% in NCAM-deficient Rip1Tag2 mice) and, with it, increased lymphangiogenesis (0% in wild-type &lt;i&gt;versus&lt;/i&gt; 19% in NCAM-deficient Rip1Tag2 mice). Repression of VEGF-C and -D function by adenoviral expression of a soluble form of their cognate receptor, VEGF receptor-3, results in reduced tumor lymphangiogenesis (56% &lt;i&gt;versus&lt;/i&gt; 28% in control &lt;i&gt;versus&lt;/i&gt; treated mice) and lymph node metastasis (36% &lt;i&gt;versus&lt;/i&gt; 8% in control &lt;i&gt;versus&lt;/i&gt; treated mice). The results indicate that the loss of NCAM function causes lymph node metastasis via VEGF-C- and VEGF-D-mediated lymphangiogenesis. These results also establish Rip1Tag2;NCAM-deficient mice as a unique model for stochastic, endogenous tumor lymphangiogenesis and lymph node metastasis in immunocompetent mice.&lt;/p&gt;&lt;/div&gt;
Mutations at palmitylation sites of the influenza virus hemagglutinin affect virus formation (1994)

The carboxy terminus of the hemagglutinin (HA) of influenza A viruses contains three cysteine residues which are highly conserved among HA subtypes. It has previously been shown for the H2, H3, and H7 subtypes of HA that these cysteine residues are modified by the covalent attachment of palmitic acid. In order to study the role of the acylated cysteines in the formation of infectious influenza viruses, we introduced mutations into the HA of influenza A/WSN/33 virus (H1 subtype) by reverse-genetics techniques. We found that the cysteine at position 563 of the cytoplasmic tail is required for infectious-particle formation. The cysteine at position 560 can be changed to alanine or tyrosine to yield virus strains that are attenuated in cell cultures. The change from cysteine at position 553 to serine or alanine does not significantly alter the phenotype of the virus. The requirement for a cysteine at position 563 suggests a functional role for palmitylation of the cytoplasmic tail. This interpretation is further supported by experiments in which two or more of the cysteine residues were mutated, eliminating potential palmitylation sites. None of these double or triple mutations resulted in infectious virus. Selection of revertants of the attenuated cysteine-to-tyrosine mutant (mutation at position 560) always resulted in reversion to cysteine rather than to other amino acids. Although our data indicate a biological role for the conserved cysteine residues in the cytoplasmic tail of the HA of influenza viruses, we cannot exclude the possibility that structural constraints in the cytoplasmic tail of the HA--rather than altered palmitylation--are the determining factors for infectious-particle formation.
C-SATS: Assessing Surgical Skills Among Urology Residency Applicants (2016)

Crowd-source assessment of resident applicant surgical skills has good inter-rater agreement with expert physician raters but not with a computer-based objective motion metrics software assessment. Overall applicant rank was affected to some degree by the crowd performance rating.
Teaching concurrency (2009)

research-article Share on Teaching concurrency Author: Leslie Lamport Microsoft MicrosoftView Profile Authors Info & Claims ACM SIGACT NewsVolume 40Issue 1March 2009 pp 58–62https://doi.org/10.1145/1515698.1515713Published:28 February 2009Publication History 4citation584DownloadsMetricsTotal Citations4Total Downloads584Last 12 Months23Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Divergent Phenotypes of Vision and Accessory Visual Function in Mice with Visual Cycle Dysfunction (Rpe65rd12) or Retinal Degeneration (rd/rd) (2008)

A major concern for gene and cell replacement therapies is the development of visual pathways through which restored retinal function can connect to visual centers of the brain. The residual retinal response to high illumination in Rpe65 rd12 mice translates into useful vision, and visual pathways remain functional--a prerequisite for restoring vision in disorders of the retina. Similarly, useful vision in young rd/rd mice shows that there is visual pathway function before photoreceptor degeneration and suggests the potential for early therapy. Together, these findings recommend observation of masking responses in the assessment of gene and cell replacement therapies.
Transfert trophique du mercure depuis l'élodée Elodea nutallii au curstacé Gammarus fossarum (2016)

[Departement_IRSTEA]Eaux [TR1_IRSTEA]BELCA
Multimedia content acquisition and processing in the MIRACLE system (2006)

This paper describes the content acquisition, indexing and repurposing components of the MIRACLE system. MIRACLE is an ongoing research project at AT&T Labs aimed at creating automated content-based media processing algorithms and systems to collect, organize, index, mine, and repurpose video and multimedia information. While the retrieval engine and the user interface are the most visible part of the query process, performing the required processing to extract the relevant information and generate the indices for the retrieval engine is the most crucial and challenging component of the overall system. Moreover, the utility of the system is highly dependent on the quality and quantity of the acquired data. We discuss a scalable processing architecture for extracting information that enables efficient searching and browsing of more than 32,000 hours of video programs. We describe a new version of the acquisition system that takes advantage of Personal Video Recorder (PVR) functionality of Windows OS to acquire high-quality video and the associated metadata.
Clinical Trials for Solid Tumors Using Electrochemotherapy (2003)

Chemotherapy is a standard treatment for a wide variety of cancers. However, response rates are usually low. In melanoma, for example, partial response rates range from 20-45 % with complete responses of less than 5% (1-4). The cell membrane can be a significant barrier for agents with an intracellular site of action. The inability to cross the cell membrane and enter the cell could lead to a low response rate. The effectiveness of these agents could be enhanced if combined with a procedure that increases the permeability of the cell membrane.
Anti-inflammatory effects of spermidine in lipopolysaccharide-stimulated BV2 microglial cells (2012)

The results indicate that spermidine appears to inhibit inflammation stimulated by LPS by blocking the NF-κB, PI3K/Akt and MAPKs signaling pathways in microglia.
Natural killer cells in the human lung tumor microenvironment display immune inhibitory functions (2020)

These findings demonstrate novel molecular cues associated with NK cell inhibitory functions in NSCLC.
Solvent effects on the alternating copolymerization systems. Evaluation on equilibrium constants by NMR spectroscopy (1972)

Abstract The contributions of the charge‐transfer complexes to the alternating copolymerizations ( e.g. , the styrene/maleic anhydride system) were studied. From the facts that the complex concentrations changed in various solvents and the rates of copolymerization depended on the solvent species, the behavior of the alternating copolymerization was considered to be controlled by the quantities of the reactive monomer complexes. In relatively strong donor solvents such as acetone and tetrahydrofuran, the concentrations of the monomer complexes were low because acceptor monomers also form complexes with the solvents. Therefore, the contributions of the monomer complexes to the copolymerization were neglectable. On the other hand, in benzene and carbon tetrachloride, which interact with acceptor monomers relatively weakly, the concentrations of the monomer complexes were relatively high. Then the copolymerizations were mainly controlled by the reactive monomer complexes. After all, it was suggested that the uncomplexed monomers as well as the complexed monomers should be taken into account on discussing the mechanisms of the alternating copolymerization between donor and acceptor monomers. In addition, the equilibrium constants or the complex concentrations could be determined in n ‐hexane by the use of NMR spectra.
Synthesis of Densely Packaged, Ultrasmall Pt02 Clusters within a Thioether‐Functionalized MOF: Catalytic Activity in Industrial Reactions at Low Temperature (2018)

Abstract The gram‐scale synthesis, stabilization, and characterization of well‐defined ultrasmall subnanometric catalytic clusters on solids is a challenge. The chemical synthesis and X‐ray snapshots of Pt 0 2 clusters, homogenously distributed and densely packaged within the channels of a metal–organic framework, is presented. This hybrid material catalyzes efficiently, and even more importantly from an economic and environmental viewpoint, at low temperature (25 to 140 °C), energetically costly industrial reactions in the gas phase such as HCN production, CO 2 methanation, and alkene hydrogenations. These results open the way for the design of precisely defined catalytically active ultrasmall metal clusters in solids for technically easier, cheaper, and dramatically less‐dangerous industrial reactions.
Catalytic Carbophilic Activation: Catalysis by Platinum and Gold π Acids (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Heterodimetallic copper(ii) compounds containing ferrocenecarboxylato(–1) and triamines as ligands (2001)

The syntheses and characterization of two new copper(II) complexes [Cu(petdien){η2-O2C[(η5-C5H4)Fe(η5-C5H5)]}][BPh4] 1 and [Cu(pmdien)(H2O){η1-O2C[(η5-C5H4)Fe(η5-C5H5)]}](ClO4) 2 (petdien = N,N,N′,N″,N″-pentaethyldiethylenetriamine, pmdien = N,N,N′,N″,N″-pentamethyldiethylenetriamine) are reported. The structures of both compounds have been determined by X-ray diffraction and reveal that these complexes contain a heterodinuclear Cu(II)–Fe(II) cation in which the ferrocenecarboxylato(−1) ligand acts as a chelating agent in 1 or as a monodentate group in 2. The influence of the steric effects induced by the tridentate amines in the mode of binding of the ferrocenecarboxylato group is discussed. Magnetochemical studies of these compounds are also reported.
Organic integrated complementary inverters with ink-jet printed source/drain electrodes and sub-micron channels (2012)

We have demonstrated device operation of down-scaled n-type field effect transistors (FETs) with ink-jet printed source/drain contacts and sub-μm channel length, using the P(NDI2OD-T2) semiconducting polymer as active material. We integrated these devices with down-scaled p-type FETs made with bis(triisopropylsilylethynyl)pentacene to fabricate complementary inverter gates, in which both transistors and the printed interconnections were implemented on the same substrate. The devices operate at 10 V supply voltage, achieve noise margin values of 56% of VDD2 and a gain higher than 10. They are therefore suitable for printed, high performance organic integrated circuits with low supply voltage.
A New Efficient Synthesis of 5-Aryloxazoles from Arylidene Diacetates and Application to the Preparation of BMS-337197, a Novel IMPDH Inhibitor (2006)

A new method for the synthesis of 5-aryloxazoles is described.Treatment of arylidene diacetates with one equivalent of TosMIC reagent in the presence of excess of potassium carbonate in methanol afforded 5-aryloxazoles in "one-pot" in 90-94%.Heteroarylidene diacetates reacted in a similar way.Application of the new method to the synthesis of the novel IMPDH inhibitor BMS-337197 is also presented.p-Tosylmethyl isocyanide (TosMIC) is a versatile reagent in organic synthesis. 1It is particularly useful in the synthesis of azoles such as oxazoles, imidazoles, thiazoles, 1,2,4-triazoles, pyrroles and others. 1,2 Recently, we extended the application of TosMIC reagent to the synthesis of 1-arylimidazole-5-carboxylates 2a,2d and imidazo[1,5-a]quinoxalin-4-ones, 2b-d both important intermediates for the preparation of biologically important and medicinally useful agents.In the course of our study towards the discovery of the novel inosine monophosphate dehydrogenase (IMPDH) inhibitor BMS-337197 and others, 3,4 we required an easy access to large amounts of 5-(2-methoxy-4-nitrophenyl)oxazole (3a). 4This compound was previously prepared in a stepwise fashion from 2-methoxy-4-nitrobenzylidene diacetate (1a) in 61% overall yield with a key step being TosMIC mediated oxazole formation through aldehyde (2a) (Scheme 1). 5 Thus, acidic hydrolysis of 1a with concentrated HCl in dioxane under reflux overnight afforded 2-methoxy-4-nitrobenzaldehyde (2a) in 89% yield.Subsequent reaction of 2a with TosMIC reagent in methanol using potassium carbonate as base gave 3a in 68% yield. 5,6While this stepwise method can be used to prepare the desired compound (3a),