gebhart/patrepeval huggingface dataset:
Journal Info Home About the Journal Editorial Board Archive Research Topics View Some Authors Review Guidelines Subscribe to Alerts Search Article Type Publication Date ...... Go Author Info Why Submit? Fees Article Types Author Guidelines Submission Checklist Contact Editorial Office Submit Manuscript Review ARTICLE Abstract Full Text PDF 0 Write a Comment Primary immunodeficiency diseases: an update on the classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency (2011)

We report the updated classification of primary immunodeficiency diseases, compiled by the ad hoc Expert Committee of the International Union of Immunological Societies. As compared to the previous edition, more than 15 novel disease entities have been added in the updated version. For each disorders, the key clinical and laboratory features are provided. This updated classification is meant to help in the diagnostic approach to patients with these diseases.
Integrated AC to AC Converters for Single-phase Input to Two-phase Output Motor Drives (2021)

The single-phase to two-phase converters have become attractive for low-power motor drives due to the full electromagnetic isolation between phases of two-phase motors. One of the commonly used topologies is the ac/dc/ac pulse width modulation (PWM) converter which contains twelve active power semiconductor switches and a common dc link. To minimize the system cost and size for low power applications, an integrated ac/ac converter with a single-phase input and a two-phase output which reduces the switch count to six is proposed in this paper. Additionally, modulation scheme and filters for the proposed converter are developed and modeled in details. In this paper a systematic comparison among the conventional ac/dc/ac converters, matrix converters, and the proposed integrated ac to ac converters for single-phase input to two-phase output motor drives applications is performed in terms of the output voltage/current capability, total harmonics distortion (THD), and system cost. Furthermore, closed-loop speed controllers are developed for the three topologies, and the maximum operation range and output phase currents are investigated. Simulation and experimental results validated the effectiveness of the developed converters and control strategies.
Generalizability of Deep Learning Segmentation Algorithms for Automated Assessment of Cartilage Morphology and MRI Relaxometry (2022)

1 TECHNICAL EFFICACY: Stage 1.
Abstract A079: The quadruplex-binding compound QN-302 in the MIA-PaCa2 pancreatic adenocarcinoma model shows no evidence of cardiac or neurological liabilities at therapeutic doses (2022)

Abstract The human genome contains multiple sites of quadruplex (G4) arrangements, with over-representation in promoter regions of many oncogenes. Small molecule G4 stabilization down-regulates the transcription of these genes, leading to selective inhibition of cancer cell growth and anti-tumor activity. We have developed a number of novel G4-binding small molecules. QN-302, the most potent, has significant in vivo activity in animal models for pancreatic cancer and is currently in pre-clinical development with Qualigen Therapeutics. The effects of QN-302 have been examined on (1) a panel of cardiac function receptors, (2) heart rate in vivo, and (3) on the histopathology of organs from treated animals. QN-302 was initially screened in a series of in vitro industry-standard CEREP receptor binding assays. The few apparent indications of significant receptor binding were examined in vivo by means of ELISA assays. Cardiac function was examined using a cardiac heart-beat monitor attached to animals treated with QN-302 and compared to animals dosed with a vehicle control. QN-302 gave negative results in CEREP assays, apart from micromolar inhibition of acetylcholinesterase (ACE) and muscarinic (MUSC) receptors. There was no significant hERG receptor inhibition. There was no significant inhibition of ACE and MUSC receptors in vivo. Heart rate experiments, run at both the proposed therapeutic dose of 1mg/kg and at elevated levels, did not show significant deviations from values for the vehicle control arm. Histopathology of heart, liver and brain tissues from QN-302 treated animals, did not show any deleterious effects from the drug. The lack of effects on ACE and MUSC receptors in vivo, together with the absence of effects on heart, liver and brain tissue from treated animals and the normality of heart rate during treatment, demonstrate that treatment of MIA-Paca2 tumor-bearing mice with QN-302 does not have a cardio-, nephro- or neurotoxic burden at therapeutic doses. QN-302 is bio-available at therapeutic doses and is currently in pre-clinical development with Qualigen Therapeutics Inc Citation Format: Ahmed Ahmed, Tariq Arshad, Stephen Neidle. The quadruplex-binding compound QN-302 in the MIA-PaCa2 pancreatic adenocarcinoma model shows no evidence of cardiac or neurological liabilities at therapeutic doses [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer; 2022 Sep 13-16; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2022;82(22 Suppl):Abstract nr A079.
Increased inducible nitric oxide synthase and arginase II expression in heart failure: no net nitrite/nitrate production and protein S-nitrosylation (2010)

Our objective was to address the balance of inducible nitric oxide (NO) synthase (iNOS) and arginase and their contribution to contractile dysfunction in heart failure (HF). Excessive NO formation is thought to contribute to contractile dysfunction; in macrophages, increased iNOS expression is associated with increased arginase expression, which competes with iNOS for arginine. With substrate limitation, iNOS may become uncoupled and produce reactive oxygen species (ROS). In rabbits, HF was induced by left ventricular (LV) pacing (400 beats/min) for 3 wk. iNOS mRNA [quantitative real-time PCR (qRT-PCR)] and protein expression (confocal microscopy) were detected, and arginase II expression was quantified with Western blot; serum arginine and myocardial nitrite and nitrate concentrations were determined by chemiluminescence, and protein S-nitrosylation with Western blot. Superoxide anions were quantified with dihydroethidine staining. HF rabbits had increased LV end-diastolic diameter [20.0 + or - 0.5 (SE) vs. 17.2 + or - 0.3 mm in sham] and decreased systolic fractional shortening (11.1 + or - 1.4 vs. 30.6 + or - 0.7% in sham; both P < 0.05). Myocardial iNOS mRNA and protein expression were increased, however, not associated with increased myocardial nitrite or nitrate concentrations or protein S-nitrosylation. The serum arginine concentration was decreased (124.3 + or - 5.6 vs. 155.4 + or - 12.0 micromol/l in sham; P < 0.05) at a time when cardiac arginase II expression was increased (0.06 + or - 0.01 vs. 0.02 + or - 0.01 arbitrary units in sham; P < 0.05). Inhibition of iNOS with 1400W attenuated superoxide anion formation and contractile dysfunction in failing hearts. Concomitant increases in iNOS and arginase expression result in unchanged NO species and protein S-nitrosylation; with substrate limitation, uncoupled iNOS produces superoxide anions and contributes to contractile dysfunction.
Frontiers of Mid-IR Lasers Based on Transition Metal Doped Chalcogenides (2018)

Enabling broad tunability, high peak and average power, ultrashort pulse duration, and all known modes of laser operation-transition-metal (TM)-doped II-VI chalcogenides are the materials of choice for direct lasing in the mid-IR. The host materials feature broad infrared transparency, high thermal conductivity, low phonon cutoff, low optical losses, and are available as either single crystals or polycrystalline ceramics. Doped with TM ions, these media exhibit a four-level energy structure, the absence of excited state absorption, as well as broad absorption and emission bands. Doped single-crystals of high optical quality are difficult to grow; however, the advent of postgrowth diffusion doped ceramics has resulted in significant progress in laser development. Here, we summarize recent experimental laser results on Cr and Fe doped II-VI chalcogenides providing access to the 1.8-6 μm spectral range with a high (>60%) efficiency, multi-Watt-level [140 W in continuous wave (CW)] output powers, tunability of >1000 nm, short-pulse (<;16 fs) multi-Watt oscillation, and multi-Joule output energies in free running and gain-switched regimes. We also review recent results on hybrid fiber-bulk (Er-fiber/Er:YAG, Tm-fiber: Ho:YAG/YLF) systems combining high efficiency of CW fiber lasers with high pulse energies of bulk materials and serving as pump sources of gain-switched Cr:II-VI lasers.
Electron spectroscopy of ceramics (1993)

High resolution, analytical and conventional TEM techniques/analyses have had considerable impact on ceramic science and engineering. Recently, the focus is shifted to the use of less traditional such as transmission EELS and novel techniques such as electron holography, STM, AFM etc.. In this contribution we illustrate the power and potential for transmission EELS in high spatial/energy resolution analysis of charge carriers in ceramic superconductors. Traditionally, optical and x-ray spectroscopies have been successfully utilized to probe the electronic structure of solids. The oxide superconductors, however, are marred by inhomogeneity of structure, chemistry and consequently the electronic structure. Thus, though very powerful, dedicated EELS has its limitations. Furthermore, these compounds possess highly anisotropic crystal and electronic structure. As an alternative, we have demonstrated that our 200 keV Hitachi HF-2000 cFEG TEM offers adequate energy, momentum transfer ( q ) and spatial resolution (&lt; 0.5 eV at zero loss, ∼ 0.10Å -1 and &lt; 1-2 nm, respectively) to realistically address these issues.
Development of Multi-Qubit Color Center Quantum Memory Module (2022)

We report on the engineering of a multi-qubit silicon-vacancy-based quantum memory module suitable for quantum networking over optical channels.
Longitudinal Stability Augmentation of Seaplanes in Planing (2015)

The towing tank experiments conducted at the Yokohama National University from November 30 to December 9 in 2005, suggested a new way of suppressing a dangerous coupled motion between heave and pitch called porpoising. This research develops on the observations made in the experiments and conducts numerical simulations to further investigate the parametric design space. Two Linear-Time-Invariant models were developed: rigid-body planing craft (conventional float planes or flying boats) and flexibly supported planing craft. The latter can simulate the new method found in the experiments for suppressing porpoising. In this study, the stability of the oscillatory motions was analyzed to see the effect of design variables to the inception of porpoising. The parametric study of flexibly supported float planes in the context of porpoising is a new contribution in the conceptual design of seaplanes.
Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA) on human neural stem cell cultures derived from the fetal cortex (2004)

Dehydroepiandrosterone (DHEA) is a neurosteroid with potential effects on neurogenesis and neuronal survival in humans. However, most studies on DHEA have been performed in rodents, and there is little direct evidence for biological effects on the human nervous system. Furthermore, the mechanism of its action is unknown. Here, we show that DHEA significantly increased the growth rates of human neural stem cells derived from the fetal cortex and grown with both epidermal growth factor (EGF) and leukemia inhibitory factor (LIF). However, it had no effect on cultures grown in either factor alone, suggesting a specific action on the EGF/LIF-responsive cell. Precursors of DHEA such as pregnenolone or six of its major metabolites, had no significant effect on proliferation rates. DHEA did not alter the small number (<3%) of newly formed neuroblasts or the large number (>95%) of nestin-positive precursors. However, the number of glial fibrillary acidic protein-positive cells, its mRNA, and protein were significantly increased by DHEA. We found both N-methyl-d-aspartate and sigma 1 antagonists, but not GABA antagonists, could completely eliminate the effects of DHEA on stem cell proliferation. Finally we asked whether the EGF/LIF/DHEA-responsive stem cells had an increased potential for neurogenesis and found a 29% increase in neuronal production when compared to cultures grown in EGF/LIF alone. Together these data suggest that DHEA is involved in the maintenance and division of human neural stem cells. Given the wide availability of this neurosteroid, this finding has important implications for future use.
From Hard to Soft: Understanding Deep Network Nonlinearities via Vector Quantization and Statistical Inference (2018)

Nonlinearity is crucial to the performance of a deep (neural) network (DN). To date there has been little progress understanding the menagerie of available nonlinearities, but recently progress has been made on understanding the rôle played by piecewise affine and convex nonlinearities like the ReLU and absolute value activation functions and max-pooling. In particular, DN layers constructed from these operations can be interpreted as {\em max-affine spline operators} (MASOs) that have an elegant link to vector quantization (VQ) and $K$-means. While this is good theoretical progress, the entire MASO approach is predicated on the requirement that the nonlinearities be piecewise affine and convex, which precludes important activation functions like the sigmoid, hyperbolic tangent, and softmax. {\em This paper extends the MASO framework to these and an infinitely large class of new nonlinearities by linking deterministic MASOs with probabilistic Gaussian Mixture Models (GMMs).} We show that, under a GMM, piecewise affine, convex nonlinearities like ReLU, absolute value, and max-pooling can be interpreted as solutions to certain natural "hard" VQ inference problems, while sigmoid, hyperbolic tangent, and softmax can be interpreted as solutions to corresponding "soft" VQ inference problems. We further extend the framework by hybridizing the hard and soft VQ optimizations to create a $β$-VQ inference that interpolates between hard, soft, and linear VQ inference. A prime example of a $β$-VQ DN nonlinearity is the {\em swish} nonlinearity, which offers state-of-the-art performance in a range of computer vision tasks but was developed ad hoc by experimentation. Finally, we validate with experiments an important assertion of our theory, namely that DN performance can be significantly improved by enforcing orthogonality in its linear filters.
TBAF-Mediated Aldol Reaction of β-Allenoates: Regio- and Stereoselective Synthesis of (2E,4E)-4-Carbinol Alkadienoates (2009)

The aldol reaction of beta-allenoate with use of a commercial THF solution of tetrabutylammonium fluoride (TBAF) yielded polyfunctionalized (2E,4E)-4-carbinol alkadienoate-a valuable building block-in highly regio- and stereoselective fashion.
The Augmentation of Internal Blade Tip-Cap Cooling by Arrays of Shaped Pins (2007)

The objective of the present study is to demonstrate a method to provide substantially increased convective heat flux on the internal cooled tip cap of a turbine blade. The new tip cap augmentation consists of several variations involving the fabrication or placement of arrays of discrete shaped pins on the internal tip cap surface. Due to the nature of flow in a 180-degree turn, the augmentation mechanism and geometry have been designed to accommodate a mixture of impingement-like flow, channel flow, and strong secondary flows. A large-scale model of a sharp 180-degree tip turn is used with the liquid crystal thermography method to obtain detailed heat transfer distributions over the internal tip cap surface. Inlet channel Reynolds numbers range from 200,000 to 450,000 in this study. The inlet and exit passages have aspect ratios of 2:1, while the tip turn divider-to-cap distance maintains nearly the same hydraulic diameter as the passages. Five tip cap surfaces were tested including a smooth surface, two different heights of aluminum pin arrays, one more closely spaced pin array, and one pin array made of insulating material. Effective heat transfer coefficients based on the original smooth surface area were increased by up to a factor of 2.5. Most of this increase is due to the added surface area of the pin array. However, factoring this surface area effect out shows that the heat transfer coefficient has also been increased by about 20 to 30%, primarily over the base region of the tip cap itself. This augmentation method resulted in negligible increase in tip turn pressure drop over that of a smooth surface.
Resource Sharing in the Logistics of the Offshore Wind Farm Installation Process based on a Simulation Study (2017)

This present contribution examines by means of a discrete event and agent-based simulation the potential of a joint use of resources in the installation phase of offshore wind energy. To this end, wind farm projects to be installed simultaneously are being examined, the impact of weather restrictions on the processes of loading, transport and installation are also taken into consideration, and both the wind farm specific resource allocation and the approach of a resource pool or resource sharing, respectively, are being implemented. This study is motivated by the large number of wind farms that will be installed in the future and by the potential savings that might be realized through resource sharing. While, so far, the main driver of the resource sharing approach has been the end consumer market, it has been applied in more and more areas, even in relatively conservative industries such as logistics. After the presentation of the backgrounds and of the underlying methodology, and the description of the prior art in this context, the network of the offshore wind energy installation phase will be described. This is the basis for the subsequent determination of the savings potential of a shared resource utilization, which is determined by the performance indicators such as the total installation time and degree of utilization of the resources. The results of the simulation show that weather restrictions have a significant effect on the installation times and the usage times of the resources as well as on their degree of utilization. In addition, the resource sharing approach, has been identified to have significant savings potential for the offshore wind energy installation.
Exploring Factors That Determine Cis/Trans Structure and Tacticity in Polymers Prepared by Ring-Opening Metathesis Polymerizations with Initiators of the Type syn- and anti-Mo(NAr)(CHCMe2Ph)(OR)2. Observation of a Temperature-Dependent Cis/Trans Ratio (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExploring Factors That Determine Cis/Trans Structure and Tacticity in Polymers Prepared by Ring-Opening Metathesis Polymerizations with Initiators of the Type syn- and anti-Mo(NAr)(CHCMe2Ph)(OR)2. Observation of a Temperature-Dependent Cis/Trans RatioRichard R. Schrock, Jin-Kyu Lee, Richard O'Dell, and John H. OskamCite this: Macromolecules 1995, 28, 17, 5933–5940Publication Date (Print):August 1, 1995Publication History Published online1 May 2002Published inissue 1 August 1995https://pubs.acs.org/doi/10.1021/ma00121a033https://doi.org/10.1021/ma00121a033research-articleACS PublicationsRequest reuse permissionsArticle Views444Altmetric-Citations95LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Helix (2016)

In the past, aggregation and self-assembly have been associated principally with micellar and colloidal systems of molecules; however, with the advent of supramolecular chemistry, molecular self-assembly has been opened to a much wider understanding that has facilitated access to a variety of different shapes and sizes, along with the construction of new and fascinating molecular topologies. This document aims at defining more than 150 terms related to aggregation and self-assembly in the particular case of macromolecules. The list is restricted to the most commonly encountered terms.
Ripple Design of LT Codes for BIAWGN Channels (2014)

This paper presents a novel framework, which enables a design of rateless codes for binary input additive white Gaussian noise (BIAWGN) channels, using the ripple-based approach known from the works for the binary erasure channel (BEC). We reveal that several aspects of the analytical results from the BEC also hold in BIAWGN channels. The presented framework is applied in a code design example, which shows promising results compared to existing work. In particular it shows a great robustness towards variations in the signal-to-noise power ratio (SNR), contrary to existing codes.
High-throughput single-cell functional elucidation of neurodevelopmental disease–associated genes reveals convergent mechanisms altering neuronal differentiation (2020)

The overwhelming success of exome- and genome-wide association studies in discovering thousands of disease-associated genes necessitates developing novel high-throughput functional genomics approaches to elucidate the molecular mechanisms of these genes. Here, we have coupled multiplexed repression of neurodevelopmental disease-associated genes to single-cell transcriptional profiling in differentiating human neurons to rapidly assay the functions of multiple genes in a disease-relevant context, assess potentially convergent mechanisms, and prioritize genes for specific functional assays. For a set of 13 autism spectrum disorder (ASD)-associated genes, we show that this approach generated important mechanistic insights, revealing two functionally convergent modules of ASD genes: one that delays neuron differentiation and one that accelerates it. Five genes that delay neuron differentiation (<i>ADNP</i>, <i>ARID1B</i>, <i>ASH1L</i>, <i>CHD2</i>, and <i>DYRK1A</i>) mechanistically converge, as they all dysregulate genes involved in cell-cycle control and progenitor cell proliferation. Live-cell imaging after individual ASD-gene repression validated this functional module, confirming that these genes reduce neural progenitor cell proliferation and neurite growth. Finally, these functionally convergent ASD gene modules predicted shared clinical phenotypes among individuals with mutations in these genes. Altogether, these results show the utility of a novel and simple approach for the rapid functional elucidation of neurodevelopmental disease-associated genes.