gebhart/patrepeval huggingface dataset:
Cognitive Support to Promote Shared Mental Models during Safety-Critical Situations in Cardiac Surgery (Late Breaking Report) (2018)

To address the, currently unmet, need for intra-operative safety-critical cognitive support in cardiac surgery, we have developed, validated, and implemented a series of customized checklists to address intra-operative emergencies, using a simulated operative setting. These crisis checklists are designed to provide cognitive and communication support to the operative team to reduce the likelihood of adverse events and improve adherence to best-practice guidelines. We recruited a number of content specialists including members of the hospital safety network and intraoperative cardiac surgery team members, and utilized a Delphi consensus method to develop procedure-specific guidelines for select intraoperative crises. Cardiac surgery team members were subsequently trained on utilizing the developed checklists, performed operative simulations, and were surveyed to determine checklist facility and effectiveness. We developed and validated five checklists for the following cardiac surgery crisis scenarios: (a) Cardiopulmonary Bypass Failure; (b) Systemic Air Embolism; (c) Venous Air Lock; (d) Protamine Reaction; Heparin Resistance. Upon initiation of the crisis management, a crew resource management approach was triggered. A member of the operative team was designated as the "reader" for each scenario to guide the team through the process. After training, 89% of operative team members surveyed indicated that they would like the crisis checklist to be used if they had one of these events occurring to them. Crisis management challenges members of the cardiac surgery team in reasoning accurately and according to best practice during periods of high cognitive workload and psychological stress. These crisis checklists were developed, validated, and simulated with the goal of supporting human performance and shared mental models in the clinical setting.
ENGINEERING DESIGN (2006)

No AccessInternational Plastics HandbookJun 2006ENGINEERING DESIGNTim A. Osswald, Erwin Baur, Sigrid Brinkmann, Karl Oberbach, Ernst SchmachtenbergTim A. Osswald, Erwin Baur, Sigrid Brinkmann, Karl Oberbach, Ernst Schmachtenberghttps://doi.org/10.3139/9783446407923.005SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2006Pages: 451-506Print ISBN: 978-3-446-22905-1eISBN: 978-3-446-40792-3 Copyright & Permissions© 2006 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
1383-P: Longitudinal Observation of Insulin Use and Glucose Time-in-Range in T1D Pregnancy (2020)

The target time in range (TIR) for pregnant women with type 1 diabetes (T1D) by the International Consensus on TIR is 70% between 63-140 mg/dL. This is difficult to achieve and is rarely met in the literature. Insulin use increases during pregnancy, but prospective data and guidance on pump setting adjustments are limited. Insulin pump delivery and CGM data for 17 T1D women from 3 U.S. sites were prospectively collected every 2 weeks as part of the LOIS-P trial. Subjects enrolled before 17 weeks gestational age (GA) and wore personal pumps and study Dexcom G6 CGM. Changes in mean daily total, basal and bolus doses per kilogram, and TIR for every 2 weeks GA are reported, and linear mixed effects regression models are used for evaluation across trimesters. Enrollment HbA1C was 6.4±0.8%. Total daily dose increased from 0.68 to 0.73 to 0.98 U/kg during the first, second and third trimesters, respectively (p&amp;lt;0.01). Basal dose increased from 0.31 to 0.36 to 0.44 (p&amp;lt;0.01). Bolus dose increased from 0.37 to 0.37 to 0.54 (p&amp;lt;0.01). Daily TIR was 68%, 60% and 63% (p=0.9), with 29% of subjects achieving &amp;gt;70% TIR during pregnancy. Time below target was 5%, 4% and 2%. Doses trended upwards around 24 weeks GA. Postpartum doses decreased significantly. While insulin doses were increased significantly across pregnancy, most subjects did not achieve &amp;gt; 70% TIR. Systems that are customized to this population’s targets with changing insulin sensitivity are needed. Disclosure G. O’Malley: Research Support; Self; Abbott, Dexcom, Inc. B. Ozaslan: None. C. Levister: None. M. Trinidad: None. K.N. Castorino: Research Support; Self; Abbott, Dexcom, Inc., Medtronic, Mylan, Novo Nordisk Inc. D. Desjardins: None. M. Church: None. B.H. Smith: None. S.J. Ogyaadu: None. M. Piper: None. C. Reid: None. S.K. McCrady-Spitzer: None. R. Kaur: None. W.K. Kremers: Research Support; Self; AstraZeneca. F.J. Doyle: Research Support; Self; DreaMed Diabetes, Tandem Diabetes Care, Xeris Pharmaceuticals, Inc. Stock/Shareholder; Self; Mode AGC. Other Relationship; Self; Dexcom, Inc., Insulet Corporation, Roche Diabetes Care. J.E. Pinsker: Advisory Panel; Self; Medtronic. Consultant; Self; Eli Lilly and Company, Tandem Diabetes Care. Research Support; Self; Dexcom, Inc., Eli Lilly and Company, Insulet Corporation, Medtronic, Tandem Diabetes Care. Speaker’s Bureau; Self; Tandem Diabetes Care. C.J. Levy: Consultant; Self; Dexcom, Inc. Employee; Spouse/Partner; Allergan plc. Research Support; Self; Abbott, Dexcom, Inc., Insulet Corporation. B. Rosenn: None. Y.C. Kudva: Research Support; Self; Dexcom, Inc., Roche Diabetes Care. Other Relationship; Self; Abbott. E. Dassau: Consultant; Self; Eli Lilly and Company. Research Support; Self; Dexcom, Inc., DreaMed Diabetes, Tandem Diabetes Care, Xeris Pharmaceuticals, Inc. Speaker’s Bureau; Self; Roche Diabetes Care. Other Relationship; Self; Dexcom, Inc., Insulet Corporation, Roche Diabetes Care. Funding National Institutes of Health (R01DK120358); Dexcom, Inc. (AP-2018-016)
Catalytic antibodies (1989)

Research Article| September 01 1989 Catalytic antibodies G M Blackburn; G M Blackburn †Chemistry, University of Sheffield, Sheffield S1O 2TN, U.K. Search for other works by this author on: This Site PubMed Google Scholar A S Kang; A S Kang *Krebs Institute, Department of Molecular Biology Search for other works by this author on: This Site PubMed Google Scholar G A Kingsbury; G A Kingsbury *Krebs Institute, Department of Molecular Biology Search for other works by this author on: This Site PubMed Google Scholar D R Burton D R Burton *Krebs Institute, Department of Molecular Biology Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1989) 262 (2): 381–390. https://doi.org/10.1042/bj2620381 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation G M Blackburn, A S Kang, G A Kingsbury, D R Burton; Catalytic antibodies. Biochem J 1 September 1989; 262 (2): 381–390. doi: https://doi.org/10.1042/bj2620381 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1989 London: The Biochemical Society1989 Article PDF first page preview Close Modal You do not currently have access to this content.
Nanoscale Investigation of Solid Electrolyte Interphase Inhibition on Li-Ion Battery MnO Electrodes via Atomic Layer Deposition of Al2O3 (2014)

Application of a functional surface coating on Li-ion battery electrodes can potentially result in a significant enhancement of the lifespan of the battery cell. In particular, atomic layer deposition (ALD), which can create highly conformal ultrathin oxide films on many different electrodes has been shown to increase the cyclability in these systems. In this study, we explore the impact of such films on the formation of the solid electrolyte interphase (SEI), which may explain why these films show improvements in the cycling performance. Specifically, we characterize, using in situ scanning ion conductance microscopy and other ex situ surface characterization techniques, the SEI formed on ALD Al2O3 coated and uncoated MnO electrodes. We ascertain that ∼9 Å is the minimum thickness of ALD Al2O3 that will inhibit thick SEI formation. Furthermore, we show that the ALD surface coating is robust and prevents SEI formation for at least 100 cycles. Lastly, we investigated the differences between our in situ and ex situ measurements to help determine what artifacts can result that are due to post-processing for ex situ studies.
Performance Comparisons of Jet and Mesh Nebulizers Using Different Interfaces in Simulated Spontaneously Breathing Adults and Children (2014)

In adults, delivery efficiency of JN with the valved mask was significantly greater than that with the aerosol mask (p=0.01). Aerosol delivery of JN with the mouthpiece was not statistically significant from the valved mask (p=0.123) and the aerosol mask (p=0.193). Drug delivery with MN with mouthpiece (15.42±1.4%) and valved-mask (15.15±1.1%) was greater than the open aerosol mask (7.54±0.39%; p=0.0001) in the adult lung model. With no flow mouthpiece delivery increased>2 fold (34.9±3.1%; p=.0001) compared to use of 2 lpm of flow. Using the JN with the pediatric model deposition with valved-mask (5.3±0.8%), dragon mask (4.7±0.9%), and aerosol mask (4.1±0.3%) were similar (p>0.05); while drug delivery with MN via valved-mask (11.1±0.7%) was greater than the dragon mask (6.44±0.3%; p=0.002) and aerosol mask (4.6±0.4%; p=0.002), and the dragon mask was more efficient than the open aerosol mask (p=0.009) CONCLUSION: The type of nebulizer and interface used for aerosol therapy affects delivery efficiency in these simulated spontaneously breathing adult and pediatric models. Drug delivery was greatest with the valved-mouthpiece and mask with JN and MN, while the standard aerosol mask was least efficient in these simulated spontaneously breathing adult and pediatric lung models. Delivery efficiency of JN was less than MN in all conditions tested in this study except in the aerosol mask. Lung deposition obtained with the adult lung model was more than that with the pediatric lung model.
Speech Intelligibility Enhancement by Interaural Magnification. (1990)

Hearing-impaired persons suffer from loss of speech intelligibility in noisy environments as well as from a decrease in binaural performance (e.g., interaural time and intensity discrimination). In order to improve speech intelligibility for spatially separated signal and noise sources by compensating for the reduced binaural performance, we implemented an algorithm increasing binaural dissimilarity on a digital signal processor. This algorithm is a modification of the proposal by Durlach & Pang (J. Acoust. Soc. Am. 1986; 80: 1849-1850). Speech discrimination experiments were performed under simulated spatial conditions with recordings of the speech material and the interfering noise source using a dummy head. With increasing complexity of the spatial masking condition, the binaural advantage as well as the benefits from the algorithm decreased for normal listeners. For four sensorineurally hearing-impaired listeners, only one spatial condition was tested. In addition, a battery of binaural tests (binaural masking level difference, interaural time and intensity discrimination) was performed. The results indicate that the benefits from the signal-processing technique are correlated with the remaining binaural performance.
IL-33 drives polyfunctionality and antitumor activity of a unique ST2+ NK cell population (2023)

Abstract Natural Killer (NK) cell subsets differ to ensure complementary and crucial roles in tumor immunosurveillance. Their biology is critically regulated by cytokines. Here, we show that IL-33 synergizes with IL-12 to strongly activate a subset of CD56 dim NK cells acquiring ST2 expression. Transcriptomic and biological analysis of human ST2 + CD56 dim NK cells revealed a distinct intermediate differentiation state between canonical CD56 bright and CD56 dim NK cells, combining high proliferative properties, cytokines/chemokines production, and cytotoxicity. NK cells expressing ST2 protein or exhibiting a ST2-linked transcriptional signature were identified in human and mouse tumors. Accordingly, IL-12 unleashes human breast tumor ST2 + NK cell potential to produce IFN-γ in response to IL-33 and IL-33/IL-12 co-injection resulted in a NK-dependent IFN-γ secretion and anti-tumor effects in murine mammary tumors. An IL33 hi -NK hi score in solid tumors correlated with increased progression-free patient survival. Our findings thus identify polyfunctional ST2 + NK cells which effector functions can be harnessed by IL-33 to boost anti-tumor immunity. One sentence summary The IL-33/IL-33R(ST2)/NK cell axis is a key determinant of cancer immunity and immunotherapy.
A New Low-Activity Nuclear Density Gauge for Soil Density Measurements (2021)

ABSTRACT For decades, nuclear density gauges have been used to measure the density and moisture content of soil during compaction testing in road and embankment construction. Worldwide regulatory agencies consider nuclear density gauges as controlled devices because of their inclusion of radioisotope sources. Regulatory requirements, such as the need for licensing, special storage, special transportation procedures, gauge operator training, and personal dosimetry, have become burdens for gauge users. Recently, a new nuclear density gauge for measuring soil wet density was declared exempt from licensing and other nuclear regulatory requirements in the United States. The new gauge uses an extremely low-activity radioisotope source. It further incorporates a separate probe operating on electromagnetic principles for soil moisture measurement or any other moisture measurement method the user desires. This paper presents the design features and measurement properties of this low-activity nuclear density gauge and its associated moisture probe. The measurement properties were determined from laboratory and field studies that were conducted in North Carolina, United States. These studies showed that the sensitivity and precision of wet density measurements made by the low-activity nuclear density gauge were similar to those made by a conventional nuclear density gauge. The wet density measurements made by the low-activity gauge and conventional gauge showed a strong correlation and agreement. For the two field sites studied, a silty sand subbase and a cement-treated aggregate base course, the dry density agreement between the low-activity nuclear density gauge/moisture probe and the conventional nuclear density gauge was within 3 lb/ft3 (48 kg/m3).
Titelbild: High‐Resolution Soft Lithography: Enabling Materials for Nanotechnologies (Angew. Chem. 43/2004) (2004)

Ideal geeignet für lithographisches Hochleistungsprägen sind auf Perfluorpolyethern basierende Elastomere. Das Titelbild zeigt Muster im Subnanometerbereich, die mit diesen Materialien repliziert wurden. Gründe des erfolgreichen Einsatzes sind die bemerkenswert niedrige Oberflächenenergie und die große Flexibilität. Es besteht die Hoffnung, dass mit diesen Materialien sogar noch kleinere Muster repliziert werden können. Mehr darüber erfahren Sie in der Zuschrift von J. M. De Simone, K. R. Carter et al. auf S. 5920 ff.
PERFORMANCE ANALYSIS OF SUBSPACE BASED METHODS (1988)

In this paper, we analyze the performance of two subspace based methods, ESPRIT, and the Toeplitz Approximation Method (TAM), for estimating the direction of arrival (DOA) of plane waves in white noise. In the case of a linear equispaced sensor array, it is shown that ESPRIT, like TAM, can be treated via a state space formulation leading to interesting insights. The state transition matrix estimated by ESPRIT is shown to be related to that obtained by TAM by a diagonal similarity transformation. The performance of these methods is also analyzed. In particular, aysmptotic results for the mean squared error in the estimates of the direction of arrival are derived for each of the above mentioned methods. Simple closed form expressions for the one source case are derived, and compared with the corresponding expressions for the Minimum-Norm method and MUSIC. Computer simulations are provided to substantiate the analysis.
Effect of Prostaglandin Analogues on Corneal Biomechanical Parameters Measured With a Dynamic Scheimpflug Analyzer (2021)

Topical PGAs resulted in greater corneal compliance, suggesting that the changes in the corneal biomechanical properties may lead to overestimation of the intraocular pressure-lowering effects.
CCD focal-plane image reorganization processors for lossless image compression (1992)

Four image reorganization ICs that enable real-time difference encoding for hierarchical lossless image compression are reported. Two image reorganization processors are realized on the focal-plane and two are designed for hybridization to a separate imager IC. The two focal-plane ICs represent the first integration of a 256*256 buried-channel frame-transfer CCD image sensor with additional charge-domain circuitry to enable image reformatting at video rates (28 frames/s). The four ICs generate pyramidal pixel output in 3*3 blocks with the center pixel first. Pixel data reorganization is performed through simultaneous readout of three rows of data, followed by pixel resequencing and sampling to provide differential output. A novel architecture provides simultaneous readout of multiple imager rows on the focal-plane ICs. The ICs have achieved a charge-transfer efficiency (CTE) of 0.99996 in the conventional horizontal and vertical CCD registers, and a CTE of 0.99994 in the SP/sup 3/ registers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A Microshutter for the Nanofabrication of Plasmonic Metal Alloys with Single Nanoparticle Composition Control (2023)

Alloying offers an increasingly important handle in nanomaterials design in addition to the already widely explored size and geometry of nanostructures of interest. As the key trait, the mixing of elements at the atomic level enables nanomaterials with physical or chemical properties that cannot be obtained by a single element alone, and subtle compositional variations can significantly impact these properties. Alongside the great potential of alloying, the experimental scrutiny of its impact on nanomaterial function is a challenge because the parameter space that encompasses nanostructure size, geometry, chemical composition, and structural atomic-level differences among individuals is vast and requires unrealistically large sample sets if statistically relevant and systematic data are to be obtained. To address this challenge, we have developed a microshutter device for spatially highly resolved physical vapor deposition in the lithography-based fabrication of nanostructured surfaces. As we demonstrate, it enables establishing compositional gradients across a surface with single nanostructure resolution in terms of alloy composition, which subsequently can be probed in a single experiment. As a showcase, we have nanofabricated arrays of AuAg, AuPd, and AgPd alloy nanoparticles with compositions systematically controlled at the level of single particle rows, as verified by energy dispersive X-ray and single particle plasmonic nanospectroscopy measurements, which we also compared to finite-difference time-domain simulations. Finally, motivated by their application in state-of-the-art plasmonic hydrogen sensors, we investigated PdAu alloy gradient arrays for their hydrogen sorption properties. We found distinctly composition-dependent kinetics and hysteresis and revealed a composition-dependent contribution of a single nanoparticle response to the ensemble average, which highlights the importance of alloy composition screening in single experiments with single nanoparticle resolution, as offered by the microshutter nanofabrication approach.
Guest Editorial Special Issue on Sensing and Machine Learning for Automotive Perception (2023)

There has been tremendous interest in self-driving and advanced driver assistance systems for automotives over the recent past. According to market predictions, achieving advanced levels of autonomous driving may still be significantly far from large-scale commercial deployment. One of the challenges is to obtain reliable environmental perception from onboard automotive sensors, and possibly external sensors, to support safety-critical driving. Automotive perception includes processed and learned information from multimodality sensors like lidar, camera, ultrasonic, and radar. Conventionally, this sensor information has been supporting functions like emergency braking, adaptive cruise control, and self-parking. This Special Issue explores advances in sensors, sensor system architectures, data processing, and machine learning for automotive perception. This Special Issue also aims to bridge the traditional model-based automotive sensing field with the rapidly emerging data-driven field that uses machine learning methods and focuses on feature representation for high-level semantic understanding. Driven by the efforts on automotive sensor hardware platforms and open datasets, vision-inspired deep learning has shown great potential to achieve state-of-the-art performance and yield better results than traditional signal processing methods in multiobject detection and tracking, simultaneous localization and mapping, multimodal sensor fusion, scene understanding, and interference mitigation. This Special Issue highlights advances in machine learning architectures and methods for automotive perception, alongside performance evaluation methodologies and field test results.
Relative Stereochemical Determination and Synthesis of the C1−C17 Fragment of a New Natural Polyketide (2009)

The challenging determination of the relative stereochemistry of a complex natural polyketide portion was achieved. After careful NMR analysis, a concise synthesis of a set of possible relative diastereomers (only 6 diastereomers out of the 32 initially envisioned) has been carried out using a common strategy based on enantioselective aldol reactions. With a high predictability, final NMR comparison established the relative stereochemistry of the C1-C17 fragment of this natural product.
Noncoordinate regulation of alpha-1 adrenoreceptor coupling and reexpression of alpha skeletal actin in myocardial infarction-induced left ventricular failure in rats. (1990)

To determine the effects of myocardial infarction-induced left ventricular failure on the regulation of surface alpha-1 adrenoreceptors and signal transduction, large infarcts were produced in rats and the animals killed seven days later. After the documentation of impaired left ventricular pump performance, radioligand binding studies of the alpha-1 adrenoreceptor, norepinephrine-stimulated phosphoinositol turnover, and ADP ribosylation of 41 kD substrate by pertussis toxin were examined in the hypertrophying unaffected myocardium. Moreover, the expression of sarcomeric actin isoforms was analyzed by Northern blots and hybridization with specific oligonucleotide probes. Alpha-1 adrenoreceptor density was found not to be altered in membranes obtained from the spared left ventricular tissue, whereas phosphoinositol turnover was increased 3.1-fold in the viable myocytes of infarcted hearts. Furthermore, pertussis toxin substrate was augmented 2.5-fold in membranes prepared from the surviving left ventricular myocardium. Finally, an upregulation of the skeletal actin isoform was detected in the tissue of the failing left ventricle. In conclusion, the possibility is raised that in the presence of severe myocardial dysfunction and ongoing reactive hypertrophy, effector pathways linked to the alpha-1 adrenoreceptor may stimulate the myocyte hypertrophic response which would tend to normalize cardiac hemodynamics. The reexpression of alpha skeletal actin may be a molecular indicator of the persistance of an overload on the myocardium.