gebhart/patrepeval huggingface dataset:
Delay PUF Assessment Method Based on Side-Channel and Modeling Analyzes (2016)

International audience
Static and dynamic analysis of Li-polymer battery using thermal electrochemical model (2010)

A dynamic model of a micro cell for Li-polymer battery based on the thermal electrochemical principle is developed to analyze static and dynamic performances. The micro cell model is one dimensional and coupled with two-dimensional macro cell thermal model to construct a pouch type battery. Firstly, the model is used to analyze both static and dynamic performances that include overpotentials, current distribution, potential distribution, and concentration of ions through the plane. Based on concentrations, the state of charge (SOC) and efficiency at charging and discharging cycles are calculated. In addition, effects of step current and voltage responses on terminal current, voltage and temperature distribution are analyzed. Finally, charging performance at a constant current and constant voltage is simulated and analyzed.
Solution of the spin Hamiltonian with orthorhombic hf and g tensors (I = S = 1/2). II. Application to PO4−4 and Tl2+ centers in anisotropic matrices (1982)

A theory developed previously has been used in the analysis of ESR spectra of PO4−4 and T12+ in anisotropic matrices, which enables one to analyze ESR spectra characterized by spin Hamiltonian ℋ = βH ⋅ g ⋅ S+S ⋅ A ⋅ I, where I = S = 1/2, g and A are of orthorhombic symmetry and no limitations are imposed on the relative magnitude of the hyperfine (hf) interaction. The comparison of ESR parameters for PO4−4 obtained by the newly developed treatment with those by the first- or second-order high-field approximation showed that the new theory gave better results than the high-field approximation for the centers with a moderate hf interaction. The ESR parameters of T12+ in polycrystalline sodium metaphosphate were successfully determined from the powder pattern. This is the extreme case characterized by a dominant and anisotropic hf interaction.
Application of a Physiological Ear Model to Irrelevance Reduction in Audio Coding (1999)

This paper is focussed on the quantizer step size adjustment procedure and the achieved sound quality obtained from the physiological ear model. Section 1 contains a brief review of the physiological ear model structure. The step size adjustment procedure is presented in Section 2. First results from the ISO/MPEG-2 AAC implementation are reported in Section 3. Conclusions are drawn in the last Section.
CXCL17 is a novel macrophage recruitment factor (P6215) (2013)

Abstract Chemokines chemotactic molecules that regulate the development of immune responses, There are 48 members of this human gene superfamily and for most we have a good understanding of their biology. Some, however, remain poorly characterized including CXCL17 which was the last ligand of this superfamily to be described. Recently, we reported that CXCL17 is an important mucosal chemokine that exhibits antimicrobial activity and is elevated in the bronchoalveolar lavage fluid (BALf) of patients with idiopathic pulmonary fibrosis. We have now explored the chemotactic properties of CXCL17. In vitro, CXCL17 induces chemotactic responses in monocytic cell lines and in macrophages. We also analyzed CXCL17 effects in vivo and observed that it recruits F4/80+ macrophages to the peritoneal cavity. We have obtained a Cxcl17 (-/-) mouse and observed that it exhibits decreased numbers of macrophages is several mucosal tissues when compared to wild type mice. We conclude that CXCL17 is an important macrophage chemotactic factor. In addition, this information indicates that CXCL17 is likely involved in macrophage recruitment both under homeostatic conditions and also during inflammatory responses. Importantly, CXCL17 is likely to participate in human disease as we have already observed high levels of this chemokine in IPF. Taken together, our data strongly suggests that CXCL17 may be involved in human inflammatory diseases that affect the mucosa.
Abstract 5712: Nutrient scarcity confers breast cancer brain metastasis sensitivity to serine synthesis pathway inhibition (2020)

Abstract The metabolic milieu of the brain is severely deprived of nutrients, including the amino acids serine and its catabolite glycine. The metabolic rewiring required for tumor cells to survive in the nutrient-limited environment of the brain and the metabolic vulnerabilities this confers are poorly understood. Here we demonstrate that cell-intrinsic de novo serine synthesis is a major determinant of triple-negative breast cancer (TNBC) brain metastasis. Whole proteome comparison of TNBC cells that differ in their capacity to colonize the brain reveals that 3-phosphoglycerate dehydrogenase (PHGDH), which catalyzes the rate-limiting step of glucose-derived serine synthesis, is the most significantly upregulated protein in cells that efficiently metastasize to the brain. Expression of catalytically active PHGDH in a non-brain trophic cell line promoted brain metastasis. Furthermore, genetic silencing or pharmacological inhibition of PHGDH attenuated brain metastasis burden in mice. These findings indicate that nutrient availability determines serine synthesis pathway dependence in brain metastasis, and suggest that PHGDH inhibitors may be useful in the treatment of patients with cancers that have spread to the brain. Citation Format: Bryan Ngo, Eugenie Kim, Sophia Doll, Sophia Bustraan, Alba Luengo, Shawn M. Davidson, Ahmed Ali, Gino Ferraro, Diane Kang, Jing Ni, Roger Liang, Ariana Plasger, Edward R. Kastenhuber, Roozbeh Eskandari, Sarah Bacha, Roshan Sriram, Benjamin D. Stein, Samuel F. Bakhoum, Edouard Mullarky, Matija Snuderl, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, David M. Sabatini, Drew Jones, Min Yu, Jean J. Zhao, Rakesh K. Jain, Matthew G. Vander Heiden, Matthias Mann, Lewis C. Cantley, Michael E. Pacold. Nutrient scarcity confers breast cancer brain metastasis sensitivity to serine synthesis pathway inhibition [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 5712.
Atlas-ISTN: Joint Segmentation, Registration and Atlas Construction with Image-and-Spatial Transformer Networks (2020)

Deep learning models for semantic segmentation are able to learn powerful representations for pixel-wise predictions, but are sensitive to noise at test time and do not guarantee a plausible topology. Image registration models on the other hand are able to warp known topologies to target images as a means of segmentation, but typically require large amounts of training data, and have not widely been benchmarked against pixel-wise segmentation models. We propose Atlas-ISTN, a framework that jointly learns segmentation and registration on 2D and 3D image data, and constructs a population-derived atlas in the process. Atlas-ISTN learns to segment multiple structures of interest and to register the constructed, topologically consistent atlas labelmap to an intermediate pixel-wise segmentation. Additionally, Atlas-ISTN allows for test time refinement of the model's parameters to optimize the alignment of the atlas labelmap to an intermediate pixel-wise segmentation. This process both mitigates for noise in the target image that can result in spurious pixel-wise predictions, as well as improves upon the one-pass prediction of the model. Benefits of the Atlas-ISTN framework are demonstrated qualitatively and quantitatively on 2D synthetic data and 3D cardiac computed tomography and brain magnetic resonance image data, out-performing both segmentation and registration baseline models. Atlas-ISTN also provides inter-subject correspondence of the structures of interest, enabling population-level shape and motion analysis.
On the importance of time delay and noise in thermoacoustic modeling (2020)

Identification of thermoacoustic systems usually requires low-order modeling, often obtained by means of a Galerkin projection onto a single acoustic mode. The resulting dissipative self-excited oscillator equation describes the dynamic balance between acoustic energy sources (i.e. the flame) and sinks. Previous works studied the case of a nonlinear flame response and a driving background noise or a nonlinear delayed flame response in a deterministic setting. In the present work, we extend previous efforts considering a generic nonlinear delayed flame response with noise. In the case where both the delay and the noise are considered, we show that the widely-used cubic nonlinear saturation function is inadequate because it can lead to diverging solutions, due to the unboundedness of the respective describing function. We present an analytical treatment for a generic saturation function, which is benchmarked against an arctangent saturation function which does not exhibit this shortcoming. From a linear stability analysis, the delayed equation is found to present intrinsic thermoacoustic (ITA) eigenvalues, showing that a one-mode approximation can still retain information on both the acoustic and the ITA dynamics if a delayed flame model is adopted. Additionally, the model is found to present rich nonlinear dynamics (e.g. bistability) and to reproduce mode switching between two close frequencies, which is a feature often observed experimentally in thermoacoustic systems. We show that the derivation of quantitatively accurate equations for the slowly varying amplitude and phase is not trivial. To this regard, three sets of equations are introduced and a detailed discussion is dedicated to investigate their capability to model the original system dynamics. It is concluded that, for thermoacoustic applications, one of the presented sets more accurately models the delayed interaction between the acoustics and the flame response and should therefore be considered for system identification purposes. Additionally, a statistical characterization of the oscillation shows the need for more advanced modeling of amplitude and phase processes. We present novel equations based on perturbation methods and benchmark them with respect to classical results. The study explores a large nondimensional parameter space which encompasses a wide range of thermoacoustic systems.
Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic (2019)

Direct pharmacological inhibition of RAS has remained elusive, and efforts to target CRAF have been challenging due to the complex nature of RAF signaling, downstream of activated RAS, and the poor overall kinase selectivity of putative RAF inhibitors. Herein, we describe <b>15</b> (LXH254, Aversa, R.; et al. Int. Patent WO2014151616A1, 2014), a selective B/C RAF inhibitor, which was developed by focusing on drug-like properties and selectivity. Our previous tool compound, <b>3</b> (RAF709; Nishiguchi, G. A.; et al. <i>J. Med. Chem.</i> <b>2017</b>, <i>60</i>, 4969), was potent, selective, efficacious, and well tolerated in preclinical models, but the high human intrinsic clearance precluded further development and prompted further investigation of close analogues. A structure-based approach led to a pyridine series with an alcohol side chain that could interact with the DFG loop and significantly improved cell potency. Further mitigation of human intrinsic clearance and time-dependent inhibition led to the discovery of <b>15</b>. Due to its excellent properties, it was progressed through toxicology studies and is being tested in phase 1 clinical trials.
Achievable rate improvement using common message decoding for multicell networks (2010)

The performance of a multicell wireless network is often limited by intercell interference. This paper considers the use of common-private message splitting at the transmitter and common-message decoding at the receiver for intercell interference mitigation. For a downlink multicell system with multiple antennas at the base-stations and single antenna at the mobiles, we utilize a heuristic SDP-relaxation-based strategy proposed in our previous work to determine the optimal beamforming vectors for both common and private messages, and propose a new algorithm to numerically characterize the improvement in the achievable rates with common-message decoding. Simulation results show that common message decoding can significantly improve the minimum achievable rate for cell-edge users when base-stations are close in distance to each other.
Gravitational Lensing of Gravitational Waves (1999)

The concentrated mass at the Galactic center is considered as a gravitational lens that focuses gravitational-wave energy to the Earth. It is found that 60 Hz gravitational waves from a rotating neutron star outside our Galaxy are focused onto a region having an approximate radius of 1.1×1011 m (assuming that the concentrated mass has the form of a supermassive black hole). The increase in intensity (which is proportional to the square of the increase in strain amplitude h) is by a factor of approximately 17,000. Sources within our Galaxy lead to increases in intensity by a factor that can exceed 4000.
Preparation of Bismuth Silicate Films on Si Wafer by Metalorganic Chemical Vapor Deposition (1993)

Thin films of crystalline Bi 4 Si 3 O 12 were prepared by metalorganic chemical vapor deposition for use as capacitor layers in DRAM or buffer layers for epitaxial growth of various oxide crystals on Si wafer. This film was formed at 650-820°C by the reaction between SiO 2 layer on Si and mixed gas of Bi vaporized from triphenylbismuth and O 2 . The films deposited at 760°C had a flat and homogeneous surface with a preferred orientation of crystals perpendicular to the film surface. The remaining SiO 2 was observed between deposited film and Si. For the formation of homogeneous film without underlying SiO 2 , the growth rate of bismuth silicate should be faster than the deposition rate of Bi 2 O 3 as well as the oxidation rate of Si substrate.
Fabrication of conductive oxidase-entrapping nanocomposite of mesoporous ceria–carbon for efficient electrochemical biosensor (2015)

A conductive oxidase-entrapping nanocomposite in mesostructured ceria (CeO<sub>2</sub>)–carbon is developed for electrochemical detection of H<sub>2</sub>O<sub>2</sub> and glucose without any mediators.
Search for pair and single production of new heavy quarks that decay to a Z boson and a third-generation quark in pp collisions at s = 8 $$ \sqrt{s}=8 $$ TeV with the ATLAS detector (2014)

A search is presented for the production of new heavy quarks that decay to a Z boson and a third-generation Standard Model quark. In the case of a new charge +2/3 quark (T ), the decay targeted is T Zt, while the decay targeted for a new charge -1/3 quark (B) is B Zb. The search is performed with a dataset corresponding to 20.3 fb -1 of pp collisions at s = 8 TeV recorded in 2012 with the ATLAS detector at the CERN Large Hadron Collider. Selected events contain a high transverse momentum Z boson candidate reconstructed from a pair of oppositely charged same-flavor leptons (electrons or muons), and are analyzed in two channels defined by the absence or presence of a third lepton. Hadronic jets, in particular those with properties consistent with the decay of a b-hadron, are also required to be present in selected events. Different requirements are made on the jet activity in the event in order to enhance the sensitivity to either heavy quark pair production mediated by the strong interaction, or single production mediated by the electroweak interaction. No significant excess of events above the Standard Model expectation is observed, and lower limits are derived on the mass of vector-like T and B quarks under various branching ratio hypotheses, as well as upper limits on the magnitude of electroweak coupling parameters.
Applying Formal Evaluation to Worm Defense Design (2007)

We discuss the early insertion of formal analyses in distributed malware defense evaluation, and provide an example method for applying an executable rewriting logic specification to drive both simulation and property validation of a collaborative group-based worm defense. An important aspect of the algorithm under consideration is its distributed and probabilistic nature, which makes the defense system harder to attack but unfortunately also complicates the ability of designers to fully understand its behavioral properties. We demonstrate one approach to formally analyze our case study worm defense algorithm, employing tools that facilitate both statistical simulation and property validation. Our approach is posed as complementary to the current practice of informal design specification and evaluation through network simulation.
Miniaturization of stepped-impedance low-pass filters using periodical structures (2016)

This paper proposes a design to reduce the size of traditional stepped-impedance low-pass filters and a solution to the discontinuity problem encountered in the original design. In this design, the low-impedance sections of the traditional design are replaced by periodical structures with shunt elements. The structure itself features size reduction and the new characteristic impedance is made equal to that of the high-impedance sections to eliminate the problem of discontinuity. A six-section design example is presented with its 3-dB cutoff frequency set at 2.5 GHz. The ADS simulation results show good agreement between the traditional design and the proposed design. The latter offers more than 40% in size reduction compared to the former. The simulation results are verified experimentally. Good agreement is observed.
Comparison of Arcuate-Legged Non-Penetrating Titanium Clips, Non-Absorbable Suture and Absorbable Suture for Dural Closure (1997)

Introduction: The objective of this long-term study (one year) was to evaluate non-penetrating arcuate-legged clips as an alternative to absorbable and non-absorbable sutures for dural closure. Methods: Eight adult male beagle dogs had bilateral craniotomies and duraplasties using a dural prothesis (“Dura-Guard®”) with either 6-0 silk or clips. Eight dogs received two-level lumbar laminectomies and three longitudinal-linear incisions closed with 6-0 silk, 6-0 Vicryl, and clips. Sixteen animals were studied. Groups of four dogs (two cranial, two spinal) were perfused and euthanized 6, 12, 24, and 52 weeks postoperatively. Cranial and spinal specimens were removed en bloc for both macroscopic and histologic evaluation. A grading scale to include meningocerebral and meningospinal adhesions, acute and chronic inflammation, and dural healing applied by a neuropathologist enabled non-parametric analysis (Wilcoxson signed rank test), the ANOVA statistical test, and chi-square test, for variance. Results and Conclusions: The non-penetrating clip technique caused less meningocerebral and...
Differences in vernier discrimination for grating between strabismic and anisometropic amblyopes. (1982)

Two gratings composed of lines were displayed one above the other, and the vernier threshold was measured as a function of spatial frequency and vertical separation between gratings for 12 strabismic and/or anisometropic amblyopes. The vernier acuity of the anisometropic amblyopes was similar to that of nonamblyopic eyes when scaled proportionally to their reduced grating acuity. Strabismic amblyopes, on the other hand, have poorer vernier acuity than might be predicted from their grating resolution, even at low spatial frequencies. In addition, the strabismic amblyopes showed "crowding effects" for vernier gratings well within their resolution limit, while anisometropic amblyopes, like normals, showed no such effects.
Identification of an Ethenoformyl Adduct Formed in the Reaction of the Potent Bacterial Mutagen 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone with Guanosine (1998)

3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) is a potent direct-acting bacterial mutagen and a rodent carcinogen occurring in chlorine-disinfected drinking water. In this study, we have reacted MX with guanosine, cytidine, thymidine, and calf thymus DNA in aqueous solutions. HPLC analyses of the reaction mixture of MX with guanosine showed that one main product peak was formed. In the reactions of MX with cytidine or thymidine, no product peaks representing base-modified nucleosides could be observed. The product from the MX guanosine reaction mixture was isolated by preparative chromatography on reversed phase C18 columns, and its structure was determined by UV absorbance, 1H and 13C NMR spectroscopy, and mass spectrometry. The product was identified as 3-(beta-D-ribofuranosyl)-7-formylimidazo[1,2-a]purin-9(4H)-one (epsilonfGuo), and the yield for the reaction carried out at pH 7.4 and 37 degrees C was about 0.3 mol %. The adduct could not be observed at the detection limit of five adducts per 10(7) bases in the hydrolysate of the calf thymus DNA reacted with MX. However, this failure does not rule out the possibility that lower amounts of the adduct might be involved in the observed mispairing (adenine incorporated opposite an adducted guanine base) caused by MX in the Salmonella typhimurium strain TA100.
Propylene Polymerization and Deactivation Processes with Isoselective {Cp/Flu} Zirconocene Catalysts (2021)

Industrially relevant single-site precatalysts used to produce isotactic polypropylene (iPP) include C2-symmetric {SBI} and C1-symmetric {Cp/Flu} complexes of group 4 metals. While the latter can produce iPPs with a higher degree of isotacticity, they also suffer from poor productivity compared to their {SBI} counterparts. Several causes for this trend have been suggested—2,1-Regioinsertions are frequently pointed out, as they are suspected to drive the catalyst into a dormant state. While this event does not seem to significantly impact the productivity of {SBI} systems, the influence of these regioerror is poorly documented for isoselective {Cp/Flu} precatalysts. To address this issue, new Ph2X(Cp)(Flu) (Ph2X = Ph2C, FluC, Ph2Si) proligands (2a–k) and some of the corresponding dichlorozirconocenes (3a–h,k) were synthesized. These new compounds were characterized and tested in homogeneous propylene polymerization at 60 °C and the amounts of regioerrors in the resulting polymers were examined by 13C NMR spectroscopy. A possible correlation between poor productivity and a high number of regioerrors was investigated and is discussed. Furthermore, a C-H activation process in the bulky nBu3C substituent upon activation of 4c (the dimethylated analog of 3c) by B(C6F5)3 has been evidenced by NMR; DFT calculations support this C-H activation as a deactivation mechanism.
A Convergent Total Synthesis of Hemibrevetoxin B. (2003)

A convergent biomimetic synthesis of hemibrevetoxin B from d-glucal and d-arabinose utilizes an electrophile-promoted cascade &lt;i&gt;anti&lt;/i&gt;-Baldwin cyclization of an epoxy alcohol. The epoxy alcohol arises from a palladium-catalyzed coupling of a highly functionalized organozinc compound and an alkenyl iodide, which serve as two chiral building blocks of similar size and complexity. This first successful implementation of a cascade epoxy alcohol cyclization for the synthesis of marine polycyclic ether toxins proceeds in 39 steps and 4% overall yield.
In vivo confocal endomicroscopy of peripheral lung nodules using 488 nm / 660 nm induced fluorescence and topical methylene blue (2008)

International audience