gebhart/patrepeval huggingface dataset:
Cooperation Between Systemic IgG1 and Mucosal Dimeric IgA2 Monoclonal Anti-HIV Env Antibodies: Passive Immunization Protects Indian Rhesus Macaques Against Mucosal SHIV Challenges (2021)

Understanding the interplay between systemic and mucosal anti-HIV antibodies can provide important insights to develop new prevention strategies. We used passive immunization via systemic and/or mucosal routes to establish cause-and-effect between well-characterized monoclonal antibodies and protection against intrarectal (i.r.) SHIV challenge. In a pilot study, for which we re-used animals previously exposed to SHIV but completely protected from viremia by different classes of anti-HIV neutralizing monoclonal antibodies (mAbs), we made a surprise finding: low-dose intravenous (i.v.) HGN194-IgG1, a human neutralizing mAb against the conserved V3-loop crown, was ineffective when given alone but protected 100% of animals when combined with i.r. applied HGN194-dIgA2 that by itself had only protected 17% of the animals. Here we sought to confirm the unexpected synergy between systemically administered IgG1 and mucosally applied dIgA HGN194 forms using six groups of naïve macaques (n=6/group). Animals received i.v. HGN194-IgG1 alone or combined with i.r.-administered dIgA forms; controls remained untreated. HGN194-IgG1 i.v. doses were given 24 hours before – and all i.r. dIgA doses 30 min before – i.r. exposure to a single high-dose of SHIV-1157ipEL-p. All controls became viremic. Among passively immunized animals, the combination of IgG1+dIgA2 again protected 100% of the animals. In contrast, single-agent i.v. IgG1 protected only one of six animals (17%) – consistent with our pilot data. IgG1 combined with dIgA1 or dIgA1+dIgA2 protected 83% (5/6) of the animals. The dIgA1+dIgA2 combination without the systemically administered dose of IgG1 protected 67% (4/6) of the macaques. We conclude that combining suboptimal antibody defenses at systemic and mucosal levels can yield synergy and completely prevent virus acquisition.
SIMULTANEOUS HPLC ANALYSIS OF HYDROPHOBIC PRODRUGS AND THEIR HYDROPHILIC METABOLITES IN BIOLOGICAL MEDIA WITHOUT SAMPLE PREPARATION. APPLICATION TO THE BIOTRANSFORMATION STUDIES OF PRONUCLEOTIDES DERIVED FROM 5-FLUOROURACIL (2001)

Improvements of an "on-line cleaning" HPLC method for analysis of biological samples are presented: (i) the use of cleaning precolumns filled with hydrophobic stationary phases instead of the hydrophilic ones previously used to eliminate the biological matrix: (ii) the combination in the mobile phase of anionic and cationic pairing reagents in order to retain on the precolumn all the metabolites, whatever their hydrophilicity and ionicity are. Such modifications allowed to study the biotransformation of prodrugs of 5-Fluorouracil, designed to act as antitumoral pronucleotides.
DocAMR: Multi-Sentence AMR Representation and Evaluation (2022)

Tahira Naseem, Austin Blodgett, Sadhana Kumaravel, Tim O’Gorman, Young-Suk Lee, Jeffrey Flanigan, Ramón Astudillo, Radu Florian, Salim Roukos, Nathan Schneider. Proceedings of the 2022 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies. 2022.
Pattern shape comparison methods using SEM image (2003)

We have developed a new system, 'PF-3000', which realizes the pattern shape comparison between CAD layout data and CD-SEM images. Comparison results are expressed as the difference of edge location and area in this system. Moreover, we investigated different methods of shape comparison. Fourier descriptor is one of the most useful method.
Supplemental Figure 2 from Whole-body PET Imaging of T-cell Response to Glioblastoma (2023)

&lt;p&gt;Supplemental Fig. S2 Calculation of Total Lesion Immune response (TLIR). When 3D volume of interest (VOI) was placed to include a targeted lesion (green circle), Osirix MD software automatically calculates the volume above 42% of the maximum uptake within the VOI (purple area). The threshold 42% was applied following the majority of previous clinical PET studies. TLIR was defined as mean tracer uptake within the targeted VOI multiplied by volume above 42% of maximum uptake.&lt;/p&gt;
Castells, Cities And The Network Society: Formidable Ambition, Great Intuitions, Selective Legacy (2022)

Abstract This paper reviews the formidable but selective influence of Castells' analysis of the network society and the information revolution. First, the paper argues that the theorization and the style of writing this type of grand theory have both contributed to the success of those papers but also limited their long‐term influence. Second, it argues that Castells decisively contributed to identify the importance of global networks. However, his systematic use of this social form to explain the transformations proved in part misleading. Third, his analysis of spatial transformations is particularly interesting. As an urban sociologist, he has developed a sophisticated framework to articulate cities and urbanization processes in relation to global networks, neither reifying cities nor abandoning the concept contrasting European cities with metropolitan regions.
Maximizing Student Engagement Outside the Classroom with Organic Synthesis Videos (2019)

A series of organic chemistry synthesis problem sets were provided to students. Potential solution pathways and strategies were recorded on video by the instructor and provided to students electronically via YouTube. Performance on the end-of-semester synthesis exam showed significant gains, with the average increasing by 13% after the introduction of the synthesis videos. Further studies were conducted to determine if students would benefit from video access through the augmented reality app Aurasma (HP Reveal) in comparison with access through the learning management system (LMS), but no significant increases in viewing habits or performance were found.
Silk-Encapsulated Plasmonic Biochips with Enhanced Thermal Stability (2016)

Because of their high sensitivity, cost-efficiency, and great potential as point-of-care biodiagnostic devices, plasmonic biosensors based on localized surface plasmon resonance have gained immense attention. However, most plasmonic biosensors and conventional bioassays rely on natural antibodies, which are susceptible to elevated temperatures and nonaqueous media. Hence, an expensive and cumbersome "cold chain" system is necessary to preserve the labile antibodies by maintaining optimal cold temperatures during transport, storage, and handling. Herein, we introduce a facile approach to preserve the antibody activity on a biosensor surface even at elevated temperatures. We show that silk fibroin film could be used as a protective layer to preserve the activity of a model antibody (Rabbit IgG) and cardiac troponin antibody at both room temperature and 40 °C over several days. Furthermore, a simple aqueous rinsing process restores the biofunctionality of the biosensor. This energy-efficient and environmentally friendly method represents a novel approach to eliminate the cold chain and temperature-controlled packing of diagnostic reagents and materials, thereby extending the capability of antibody-based biosensors to different resource-limited circumstances such as developing countries, an ambulance, an intensive care unit emergency room, and battlefield.
Axial-field Vernier-type Flux Modulation Machines for Low-speed Direct-drive Applications (2019)

This paper proposes different configurations of axial-field machines featuring a very large ratio of the number of rotor poles to stator teeth and coils suitable for low-speed direct-drive traction applications. The machines have a single rotor with spoke-type permanent magnets and the stator teeth include auxiliary slots, the function of which is to enhance the high-polarity component of the stator magnetomotive force interacting with the rotor to produce a net torque. The machines can be constructed with three or two phases, in which case they inherently exhibit high tolerance to faults due to the combined effect of a lack of coupling between phases and a relatively large phase inductance. A preliminary comparative simulation study shows performance improvement over a conventional reference permanent magnet synchronous machine.
Iron Deficiency Impairs Intra-Hepatic Lymphocyte Mediated Immune Response (2015)

Hepatic expression of iron homeostasis genes and serum iron parameters predict the success of immunosuppression withdrawal following clinical liver transplantation, a phenomenon known as spontaneous operational tolerance. In experimental animal models, spontaneous liver allograft tolerance is established through a process that requires intra-hepatic lymphocyte activation and deletion. Our aim was to determine if changes in systemic iron status regulate intra-hepatic lymphocyte responses. We used a murine model of lymphocyte-mediated acute liver inflammation induced by Concanavalin A (ConA) injection employing mice fed with an iron-deficient (IrDef) or an iron-balanced diet (IrRepl). While the mild iron deficiency induced by the IrDef diet did not significantly modify the steady state immune cell repertoire and systemic cytokine levels, it significantly dampened inflammatory liver damage after ConA challenge. These findings were associated with a marked decrease in T cell and NKT cell activation following ConA injection in IrDef mice. The decreased liver injury observed in IrDef mice was independent from changes in the gut microflora, and was replicated employing an iron specific chelator that did not modify intra-hepatic hepcidin secretion. Furthermore, low-dose iron chelation markedly impaired the activation of isolated T cells in vitro. All together, these results suggest that small changes in iron homeostasis can have a major effect in the regulation of intra-hepatic lymphocyte mediated responses.
A Superolaterally Placed Anchor for Subscapularis “Leading‐Edge” Refixation: A Biomechanical Study (2019)

The SSC is critical for proper shoulder function. Without an increase in the number of implants, a significantly better footprint reconstruction can be achieved by placing an anchor superior and lateral to the native footprint area close to the entrance of the bicipital groove.
A b i n i t i o SCF and CI calculations of the dipole moment function of ozone (1979)

The constant and linear terms in a Taylor series expansion of the dipole moment function of the 1A1 ground state of ozone are calculated with Cartesian Gaussian basis sets ranging in quality from minimal to double zeta plus polarization. Results are presented at both the self-consistent field and configuration–interaction levels. Although the algebraic signs of the linear dipole moment derivatives are all established to be positive, the absolute magnitudes of these quantities, as well as the infrared intensities calculated from them, vary considerably with the level of theory.
ChemInform Abstract: Mimics of L‐Rhamnose: Synthesis of C‐Glycosides of L‐Rhamnofuranose and an α‐Azidoester as Divergent Intermediates for Combinatorial Generation of Rhamnofuranose Libraries. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Superior Performance of 5-nm Gate Length GaN Nanowire nFET for Digital Logic Applications (2019)

We investigate the performance of 5-nm gate length GaN nMOS nanowire field effect transistor (GaN-NWnFET) of various geometrical shapes, around the limits of cross-sectional scalability, using atomistic quantum transport simulations. For square cross-sections, the benchmarking results with the simulated Si-NW-nFET reveal over 30% enhancement in GaN drive current in both low standby power (LP - I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">OFF</sub> = 1 nA/μm) and high performance (HP - I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">OFF</sub> = 100 nA/μm) applications. Further performance enhancement is observed with the use of non-square geometries that are akin to GaN's wurtzite crystal structure. Particularly, for T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nw</sub> = 2.4 mn, triangular cross-section GaN-NW-nFETs exhibit the smallest subthreshold swing, down to 62 mv/decade, excellent drive current, I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DSAT</sub> > 2 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> μA/μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and superior energy-delay product compared to simulated Si-NW-nFET.
Hertz-level-linewidth semiconductor laser via injection locking to an ultra-high Q silicon nitride microresonator (2021)

A conventional semiconductor DFB laser is self-injection-locked to a CMOS-foundry- fabricated ultra-high Q silicon nitride microresonator, suppressing high-offset frequency noise to 0.2 Hz 2 Hz -1 and yielding instantaneous linewidth of 1.2 Hz.
A compact human-powered energy harvesting system (2013)

This paper presents a fully functional, self-sufficient body-worn energy harvesting system for passively capturing energy from human motion, with the long-term vision of supplying power to portable, wearable, or even implanted electronic devices. The system requires no external power supplies and can bootstrap from zero-state-of-charge to generate electrical energy from walking, jogging and cycling; convert the induced ac voltage to a dc voltage; and then boost and regulate the dc voltage to charge a Li-ion-polymer battery. Tested under normal human activities (walking, jogging, cycling) when worn on different parts of the body, the 70 cm3 system is shown to charge a 3.7 V rechargeable battery at charge rates ranging from 33 μW to 234 μW.
Using Fourier analyses to enhance IC testability (2002)

In this paper, we explore the potential of FFTs in digital IC tests. The effects of three parasite contact types are investigated. Results show that unappropriate logical values on output voltages are easily detected and that FFTs on supply current can make detectable undesired contacts causing additional delays. Application of the method to technologies with non small quiescent currents and to large ICs is also discussed.
Accuracy of a Point Source Thermal Soil Moisture Sensor for Space Flight Nutrient Delivery Systems (2004)

&lt;div class="htmlview paragraph"&gt;The WONDER space flight experiment will compare the operation of both substrate-based and porous tube nutrient delivery systems (NDS) under microgravity conditions. Each NDS will be evaluated with three moisture availability regimes, and moisture sensing will be critical for the operation and evaluation of the systems. Orbital Technologies (Madison, WI) has developed a space flight-rated temperature and moisture acquisition system (TMAS) for measuring water content of plant growth medium. The sensors were evaluated in 0.25-1 mm and 1-2 mm baked ceramic aggregate (Profile and Turface, respectively). The sensors' pooled standard deviations ranged from approximately 2% to 5% relative water content (RWC), and root mean square error between sensor RWC and measured RWC was greater than 3% using linear calibration.&lt;/div&gt;
Fundamentals of EUV resist-inorganic hardmask interactions (2017)

High resolution Extreme Ultraviolet (EUV) patterning is currently limited by EUV resist thickness and pattern collapse, thus impacting the faithful image transfer into the underlying stack. Such limitation requires the investigation of improved hardmasks (HMs) as etch transfer layers for EUV patterning. Ultrathin (&lt;5nm) inorganic HMs can provide higher etch selectivity, lower post-etch LWR, decreased defectivity and wet strippability compared to spin-on hybrid HMs (e.g., SiARC), however such novel layers can induce resist adhesion failure and resist residue. Therefore, a fundamental understanding of EUV resist-inorganic HM interactions is needed in order to optimize the EUV resist interfacial behavior. In this paper, novel materials and processing techniques are introduced to characterize and improve the EUV resist-inorganic HM interface. HM surface interactions with specific EUV resist components are evaluated for open-source experimental resist formulations dissected into its individual additives using EUV contrast curves as an effective characterization method to determine post-development residue formation. Separately, an alternative adhesion promoter platform specifically tailored for a selected ultrathin inorganic HM based on amorphous silicon (aSi) is presented and the mitigation of resist delamination is exemplified for the cases of positive-tone and negative-tone development (PTD, NTD). Additionally, original wafer priming hardware for the deposition of such novel adhesion promoters is unveiled. The lessons learned in this work can be directly applied to the engineering of EUV resist materials and processes specifically designed to work on such novel HMs.
Regiospecific Synthesis of Bicyclo- and Heterobicyclo-gem-difluorocyclobutenes Using Functionalized Fluoroallenes and a Novel Mo-Catalyzed Intramolecular [2 + 2] Cycloaddition Reaction (2002)

The first synthesis of functionalized gem-difluoroallenes 4 served as platform for an unprecedented molybdenum-catalyzed intramolecular allene-alkyne [2 + 2]-cycloaddition that produced 6, a hitherto unknown class of bicyclo- and heterobicyclo-CF2-containing cyclobutenes.
Variation in Postoperative Complication Rates and Opportunities for Improvement (1999)

Society of Critical Care Medicine; 28th Educational and Scientific Symposium; San Francisco, California, USA; January 23-27, 1999: Oral Presentations
Identifying patient-specific trajectories in haemodialysis using Bayesian Hierarchical Gaussian Processes (2018)

In the domain of chronic disease monitoring, continuous time-series vital sign data (such as blood pressure) can be collected through low-cost wearable devices. Approximately 300 million people have chronic kidney disease globally. These patients undergo multiple haemodialysis sessions per week. In addition, patients are at risk of intra-dialytic hypotension, which leads to chronic heart disease and a high incidence of mortality. We propose Bayesian Hierarchical Gaussian Processes (HGPs) to model changes of systolic blood pressure (SBP) over time for continuously monitored patients. Furthermore, we use Bayesian HGPs to infer the hidden latent structure of the SBP time-series pattern/trajectory for each individual patient. To identify normal versus abnormal patterns, we further propose symmetric Kullback-Leibler divergence of multivariate normal distributions to provide a metric to identify deviations from normal latent trajectories. We apply Bayesian HGPs to a dataset of patients undergoing haemodialysis monitoring, and demonstrate its superiority in identifying abnormal SBP patterns compared to alternative state-of-the-art clustering algorithms.
Ipsilateral lower extremity joint involvement increases the risk of poor pain and function outcomes after hip or knee arthroplasty (2013)

To the best of our knowledge, this is the first study showing that the presence of ipsilateral joint involvement after THA or TKA is strongly associated with poor pain and function outcomes. A potential way to improve outcomes is to address ipsilateral lower extremity joint involvement.
OTX2 Non-Cell Autonomous Activity Regulates Inner Retinal Function (2020)

OTX2 is a homeoprotein transcription factor expressed in photoreceptors and bipolar cells in the retina. OTX2, like many other homeoproteins, transfers between cells and exerts non-cell autonomous effects such as promoting the survival of retinal ganglion cells that do not express the protein. Here we used a genetic approach to target extracellular OTX2 in the retina by conditional expression of a secreted single-chain anti-OTX2 antibody. Compared with control mice, the expression of this antibody by parvalbumin-expressing neurons in the retina is followed by a reduction in visual acuity in 1-month-old mice with no alteration of the retinal structure or cell type number or aspect. The a-waves and b-waves measured by electroretinogram were also indistinguishable from those of control mice, suggesting no functional deficit of photoreceptors and bipolar cells. Mice expressing the OTX2-neutralizing antibody did show a significant doubling in the flicker amplitude and a reduction in oscillatory potential, consistent with a change in inner retinal function. Our results show that interfering <i>in vivo</i> with OTX2 non-cell autonomous activity in the postnatal retina leads to an alteration in inner retinal cell functions and causes a deficit in visual acuity.
Diastereofacial selectivity with optically active .alpha.-substituted .beta.-silyl-(E)-hexenoates. Enantioselective construction of homoallylic ethers via reaction with aryl acetals (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiastereofacial selectivity with optically active .alpha.-substituted .beta.-silyl-(E)-hexenoates. Enantioselective construction of homoallylic ethers via reaction with aryl acetalsJames S. Panek and Michael YangCite this: J. Am. Chem. Soc. 1991, 113, 17, 6594–6600Publication Date (Print):August 1, 1991Publication History Published online1 May 2002Published inissue 1 August 1991https://pubs.acs.org/doi/10.1021/ja00017a035https://doi.org/10.1021/ja00017a035research-articleACS PublicationsRequest reuse permissionsArticle Views543Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts