gebhart/patrepeval huggingface dataset:
MP74-08 PSYCHOLOGICAL AND PHYSICAL IMPACT OF STUTTERING PRIAPISM ON MEN WITH SICKLE CELL DISEASE (2018)

You have accessJournal of UrologySexual Function/Dysfunction: Evaluation II1 Apr 2018MP74-08 PSYCHOLOGICAL AND PHYSICAL IMPACT OF STUTTERING PRIAPISM ON MEN WITH SICKLE CELL DISEASE April Szafran, Belinda Morrison, and Arthur Burnett April SzafranApril Szafran More articles by this author , Belinda MorrisonBelinda Morrison More articles by this author , and Arthur BurnettArthur Burnett More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.2392AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Stuttering priapism is a variant of ischemic priapism in which patients have recurrent painful erections unrelated to or persisting beyond sexual stimulation. Up to 42% of patients with sickle cell disease are affected by priapism, making this a significant concern in this population as it has the potential to result in psychological distress as well as impotence. The objective of this study is to determine rates of ED in sickle cell patients who have had episodes of priapism and to secondarily evaluate persistent psychological distress. METHODS 101 male patients with a past medical history of both sickle disease and priapism completed questionnaires including the Sexual Health Inventory for Men, International Index of Erectile Function and a novel questionnaire regarding the impact of priapism on their sexual function and well-being. RESULTS The subjects ranged in age from 17-67 with average age of 31. 11.4 percent had severe ED based on SHIM score. Both the SHIM and IIEF were on average consistent with mild symptoms, however. With regard to priapism, 36% of patients who completed surveys expressed substantial to very extreme worry regarding these episodes and this was associated with personal distress. CONCLUSIONS Severe erectile dysfunction is found in >11% of men affected by priapism in the setting of sickle cell disease. Priapism results in worry and distress in these men. Efforts to suppress episodes and maintain erectile tissue are of paramount importance in this patient population. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e1003 Advertisement Copyright & Permissions© 2018MetricsAuthor Information April Szafran More articles by this author Belinda Morrison More articles by this author Arthur Burnett More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
ChemInform Abstract: STEREOSELECTIVE KETONE REDUCTIONS: REDUCTION OF 4‐TERT‐BUTYLCYCLOHEXANONE BY ALKYLSILANES IN THE PRESENCE OF RHODIUM(I) AND RUTHENIUM(II) CATALYSTS (1982)

Abstract In Gegenwart der Edelmetall‐Katalysatoren (I) bzw. (II) und der Silane (III), (IV) oder (V) erhält man aus Ketonen stereoselektiv die entsprechenden Alkohole, deren Konfiguration durch den Katalysator sowie das eingesetzte Silan bestimmt wird.
A New Strictly Alternating Comblike Amphiphilic Polymer Based on PEG. 1. Synthesis and Associative Behavior of a Low Molecular Weight Sample (1999)

We describe the synthesis and associative behavior in water of a strictly alternating comblike amphiphilic polymer based on poly(ethylene glycol) (PEG). The polymer has a strictly alternating sequence of PEG blocks (Mw = 8000) of low polydispersity and hydrophobic 18 carbon-atom alkyl pendent chains. Three copolymers with Mw = 28 000, 68 000, and 113 000 were prepared. The associative behavior of the polymer of molecular weight 28 000 (on average about 3 PEG-C18 sequences per chain) in water was studied by static and dynamic light scattering, spectrofluorimetry, and viscosity measurements. The behavior resembles that of hydrophobically end capped (i.e., telechelic) PEO. Flowerlike micelles, each containing approximately 14 hydrophobes, are formed by the association of about four to five polymer chains.
Complexity of Many-Body Interactions in Transition Metals via Machine-Learned Force Fields from the TM23 Data Set (2023)

This work examines challenges associated with the accuracy of machine-learned force fields (MLFFs) for bulk solid and liquid phases of d-block elements. In exhaustive detail, we contrast the performance of force, energy, and stress predictions across the transition metals for two leading MLFF models: a kernel-based atomic cluster expansion method implemented using sparse Gaussian processes (FLARE), and an equivariant message-passing neural network (NequIP). Early transition metals present higher relative errors and are more difficult to learn relative to late platinum- and coinage-group elements, and this trend persists across model architectures. Trends in complexity of interatomic interactions for different metals are revealed via comparison of the performance of representations with different many-body order and angular resolution. Using arguments based on perturbation theory on the occupied and unoccupied d states near the Fermi level, we determine that the large, sharp d density of states both above and below the Fermi level in early transition metals leads to a more complex, harder-to-learn potential energy surface for these metals. Increasing the fictitious electronic temperature (smearing) modifies the angular sensitivity of forces and makes the early transition metal forces easier to learn. This work illustrates challenges in capturing intricate properties of metallic bonding with current leading MLFFs and provides a reference data set for transition metals, aimed at benchmarking the accuracy and improving the development of emerging machine-learned approximations.
The Tarantula Toxin ω-Avsp1a Specifically Inhibits Human CaV3.1 and CaV3.3 via the Extracellular S3-S4 Loop of the Domain 1 Voltage-Sensor (2022)

Inhibition of T-type calcium channels (Ca<sub>V</sub>3) prevents development of diseases related to cardiovascular and nerve systems. Further, knockout animal studies have revealed that some diseases are mediated by specific subtypes of Ca<sub>V</sub>3. However, subtype-specific Ca<sub>V</sub>3 inhibitors for therapeutic purposes or for studying the physiological roles of Ca<sub>V</sub>3 subtypes are missing. To bridge this gap, we employed our spider venom library and uncovered that <i>Avicularia spec.</i> ("Amazonas Purple", Peru) tarantula venom inhibited specific T-type Ca<sub>V</sub> channel subtypes. By using chromatographic and mass-spectrometric techniques, we isolated and sequenced the active toxin ω-Avsp1a, a C-terminally amidated 36 residue peptide with a molecular weight of 4224.91 Da, which comprised the major peak in the venom. Both native (4.1 μM) and synthetic ω-Avsp1a (10 μM) inhibited 90% of Ca<sub>V</sub>3.1 and Ca<sub>V</sub>3.3, but only 25% of Ca<sub>V</sub>3.2 currents. In order to investigate the toxin binding site, we generated a range of chimeric channels from the less sensitive Ca<sub>V</sub>3.2 and more sensitive Ca<sub>V</sub>3.3. Our results suggest that domain-1 of Ca<sub>V</sub>3.3 is important for the inhibitory effect of ω-Avsp1a on T-type calcium channels. Further studies revealed that a leucine of T-type calcium channels is crucial for the inhibitory effect of ω-Avsp1a.
Sonographic Depiction of Microvessel Perfusion (2004)

Microbubble-enhanced sonography can depict microvessel perfusion. This technique has several potential clinical applications, including assessment of tumor blood flow and changes that occur with treatment.
Ternary Ag/MgO‐SiO2 Catalysts for the Conversion of Ethanol into Butadiene (2015)

Abstract Invited for the cover of this issue is the group of Bert Sels at the KU Leuven. The image represents the eternal life cycle of a renewable feedstock into a recyclable product. The Full Paper itself is available at 10.1002/cssc.201402894 .
An Environment Friendly, Low-Cost Extraction Process of Phenolic Compounds from Grape Byproducts. Optimization by Multi-Response Surface Methodology (2013)

Due to their beneficial effects on human health, phenolic compounds are increasingly attracting the attention of scientists and researchers all over the world. The main interest is in the extraction process of those natural plant-originated compounds from fruits, vegetables and plant wastes, namely grape wastes, in which phenolic compounds are the most abundant secondary metabolites. This waste exploitation not only re-assimilates those byproducts into the food cycle, but also avoids major environmental problems. Herein, the optimization of the phenolic compounds concentration and free radical scavenging activity from Cabernet Sauvignon grape byproducts was conducted, using multi-response surface methodology. A conventional solid-liquid extraction process was performed with pure water as a solvent to study the effects of both time and temperature on the procedure. The maximal phenolic compounds concentration (878.9 mg/L) was reached at 47℃ after 30 hours while the optimal free radical scavenging activity (41.15%) was obtained at 30℃ after 20 hours. A multi-response surface methodology compromised between the quantity and the quality of the extracted phenolics, and the parameters maximizing both responses were obtained at 37℃ and 28 hours. This low-cost and energy saving process provides an excellent tool for further industrial applications.
Effect of Abelson murine leukemia virus on granulocytic differentiation and interleukin-3 dependence of a murine progenitor cell line. (1987)

The murine diploid hematopoietic cell line 32D Cl3 strictly requires interleukin-3 (IL-3) for proliferation. When 32D Cl3 cells are transferred to IL-3-free medium which contains recombinant human granulocyte colony stimulating factor (rhG-CSF), the cell number increases four- to five-fold, and after 14 days the whole cell population is differentiated into morphologically normal and myeloperoxidase- and lactoferrin-positive metamyelocytes and granulocytes. Infection with Abelson murine leukemia virus (A-MuLV) of 32D Cl3 cells growing in the presence of IL-3 induces, within 2 weeks, the appearance of cells that are IL-3-independent for growth. The latter cells lack myeloid, T and B cell markers, and are unable to differentiate, even in the presence of very high doses of rhG-CSF. However, once the 32D Cl3 cells have been exposed to G-CSF, they become resistant to the transforming effects of A-MuLV as judged by the appearance of the IL-3-independent clones. These findings suggest that the ability of Abelson virus to transform immature progenitor cells is due to interference of the v-abl gene product with the mechanisms that control the commitment of the cells to differentiate.
Low-Temperature Superplasticity in Aluminum Alloys Processed by Equal-Channel Angular Pressing (2002)

Equal-channel angular pressing (ECAP) was applied to achieve grain refinement of Al–3 mass%Mg alloys containing 0.2 mass%Sc, 0.2 mass%Fe or 0.1 mass%Zr. The thermal stability of the fine-grained structures was examined by conducting static annealing experiments. The fine grain sizes produced by ECAP were essentially retained up to a temperature of 523 K for the Fe-containing and Zr-containing alloys and up to a temperature as high as 773 K for the Sc-containing alloy. The three alloys with Sc, Fe and Zr additions were pulled to failure in tension at 523 K corresponding to 0.59Tm, where Tm is the absolute melting point of the alloy, and maximum elongations of ∼ 640%, ∼ 370% and ∼ 390% were obtained at an initial strain rate of 3.3×10−4 s−1, respectively. Such elongations resulted in more than three times or approximately twice the elongation achieved in a binary Al–3%Mg alloy. It is shown that either Fe or Zr may be used as an alternative element in place of Sc to attain low temperature superplasticity. Tensile testing was also conducted on the Sc-containing ternary alloy at a temperature as low as 473 K corresponding to 0.54Tm. A maximum elongation of ∼ 420% was attained at an initial strain rate of 3.3×10−4 s−1. This appears to be the lowest homologous temperature reported to date for superplasticty of Al-based alloys.
Surface-tensile-stress induced polishing-voids in cross-point phase-change-memory cells: corrosion mechanism and solution (2019)

Abstract In the fabrication of cross-point phase-change-memory-cells through atomic-layer-deposition of Ge-doped SbTe (Ge-ST) film followed by chemical-mechanical-polarization (CMP), a remarkable surface tensile stress was generated, originating from the surface stress induced by the pad down force and the surface structure tensile stress in a confined memory-cell structure. It was maximized at the position of the Si 3 N 4 -film spacer where the curvature becomes zero. The maximized surface tensile stress produced polishing induced voids via the generation mechanism of the stress corrosion cracking. The generation frequency and nanoscale size of the polishing induced voids rapidly increased at the maximum surface tensile stress during CMP. Then, they slightly decreased and saturated when the surface tensile stress reduced during further CMP. A design of a spacer using a SiO 2 -film spacer rather a Si 3 N 4 -film spacer could prevent the generation of the polishing induced voids, confirming that the generation mechanism of the polishing induced voids is associated with the stress corrosion cracking.
Ruthenium Triazine Composite: A Good Match for Increasing Hydrogen Evolution Activity through Contact Electrification (2020)

Abstract The development of Pt‐free catalysts for the alkaline hydrogen evolution reaction (HER), which is widely used in industrial scale water‐alkali electrolyzers, remains a contemporary and pressing challenge. Ruthenium (Ru) has excellent water‐dissociation abilities and could be an alternative water splitting catalyst. However, its large hydrogen binding energy limits HER activity. Here, a new approach is proposed to boost the HER activity of Ru through uniform loading of Ru nanoparticles on triazine‐ring (C 3 N 3 )‐doped carbon (triNC). The composite (Ru/triNC) exhibits outstanding HER activity with an ultralow overpotential of ≈2 mV at 10 mA cm −2 ; thereby making it the best performing electrocatalyst hitherto reported for alkaline HER. The calculated metal mass activity of Ru/triNC is &gt;10 and 15 times higher than that of Pt/C and Pt/triNC. Both theoretical and experimental studies reveal that the triazine‐ring is a good match for Ru to weaken the hydrogen binding on Ru through interfacial charge transfer via increased contact electrification. Therefore, Ru/triNC can provide the optimal hydrogen adsorption free energy (approaching zero), while maintaining the strong water‐dissociation activity. This study provides a new avenue for designing highly efficient and stable electrocatalysts for water splitting.
D2 dopamine receptors interact directly with N-type calcium channels and regulate channel surface expression levels (2008)

N-type channels are located on dendrites and at pre-synaptic nerve terminals where they play a fundamental role in neurotransmitter release. They are potently regulated by the activation of a number of different types of pertussis toxin (PTX)-sensitive G alpha(i/o) coupled receptors, which results in voltage-dependent inhibition of channel activity via G betagamma subunits. Using heterologous expression in HEK 293T cells, we show via whole cell patch clamp recordings that D2 receptors mediate both G betagamma (i.e., voltage-dependent) and voltage-independent inhibition of channel activity. Furthermore, using co-immunoprecipitation and pull down assays involving the intracellular regions of each protein, we show that D2 receptors and N-type channels form physical signaling complexes. Finally, we use confocal microscopy to demonstrate that D2 receptors regulate N-type channel trafficking to affect the number of calcium channels available at the plasma membrane. Taken together, these data provide evidence for multiple voltage-dependent and voltage-independent mechanisms by which D2 receptor subtypes influence N-type channel activity.
Signal Peptide Efficiency: From High-Throughput Data to Prediction and Explanation (2023)

The passage of proteins across biological membranes via the general secretory (Sec) pathway is a universally conserved process with critical functions in cell physiology and important industrial applications. Proteins are directed into the Sec pathway by a signal peptide at their N-terminus. Estimating the impact of physicochemical signal peptide features on protein secretion levels has not been achieved so far, partially due to the extreme sequence variability of signal peptides. To elucidate relevant features of the signal peptide sequence that influence secretion efficiency, an evaluation of ∼12,000 different designed signal peptides was performed using a novel miniaturized high-throughput assay. The results were used to train a machine learning model, and a post-hoc explanation of the model is provided. By describing each signal peptide with a selection of 156 physicochemical features, it is now possible to both quantify feature importance and predict the protein secretion levels directed by each signal peptide. Our analyses allow the detection and explanation of the relevant signal peptide features influencing the efficiency of protein secretion, generating a versatile tool for the de novo design and in silico evaluation of signal peptides.
Spatially Coupled Protograph-Based LDPC Codes for Decode-and-Forward in Erasure Relay Channel (2011)

We consider spatially-coupled protograph-based LDPC codes for the three terminal erasure relay channel. It is observed that BP threshold value, the maximal erasure probability of the channel for which decoding error probability converges to zero, of spatially-coupled codes, in particular spatially-coupled MacKay-Neal code, is close to the theoretical limit for the relay channel. Empirical results suggest that spatially-coupled protograph-based LDPC codes have great potential to achieve theoretical limit of a general relay channel.
Quantitative characterization of hemodynamic properties and vasculature dysfunction of high‐grade gliomas (2007)

Aberrations in tumor and peritumoral vasculature may not be distinguishable by cerebral blood flow (CBF) or cerebral blood volume (CBV) alone. The relationships between CBF and CBV were examined to estimate vasculature-specific hemodynamic characteristics. Twenty glioma patients were studied with dynamic susceptibility T2*-weighted MRI [(dynamic contrast-enhanced magnetic resonance imaging (DSC-MRI)] before and during week 1 and 3 of radiotherapy (RT). CBF and CBV were calculated from DSC-MRI, and relationships between the two were evaluated: the physiological measure of mean transit time (MTT) = CBV/CBF; empirical fitting using the power law CBV = constant x (CBF)(beta). Three different tissue types were assessed: the Gd-enhancing tumor volume (GEV); non-enhanced abnormal tissue located beyond GEV but within the abnormal hyperintense region on FLAIR images (NEV); normal tissue in the hemisphere contralateral to the tumor (CNT). The effects of tissue types, CBV magnitudes (low, medium and high), before and during RT, on MTT and beta were analyzed by analysis of variance (ANOVA). The MTT and beta for the three tissue types were significantly different (p < 0.009). MTT increased from CNT (1.60 s) to NEV (1.93 s) to GEV (2.28 s) (p < 0.0005). beta was significantly greater in GEV (1.079) and NEV (1.070) than in CNT (1.025). Beta increased with increasing CBV magnitude while MTT was independent of CBV magnitude. There was a significant decrease in MTT of NEV and GEV during week 3 of RT compared with pre-RT values for all CBV magnitudes. There was a significant increase in beta during RT in the tumor and peritumor. Progressive abnormalities in vasculature and hemodynamic characteristics of the vascular bed were delineated, with significant disorder in the tumor but mild abnormality in peritumoral tissue.
A low jitter, low cost, time-of-flight circuit (1988)

A low-cost, low-jitter circuit has been developed for use in a neutron time-of-flight spectrometer at the Nova Laser Facility. Using a silicon charged-particle detector, amplifier, and constant-fraction discriminator, timing resolution of better than 50 ps FWHM has been achieved. Using an array of many such detectors, very high data rates and precise spectra can be obtained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Multi-priority Cartesian Impedance Control (2011)

Manipulator compliance is well known to be important to robot manipulation and assembly.Recently, this has been highlighted by the development of new higly-compliant robot manipulators such as the Barrett arm or the DLR lightweight manipulator [1, 2].It is also clear that dexterous manipulation involves touching the environment at different locations simultaneously (perhaps at different points on the robot hand or fingers).In these situations, it is particularly attractive to control the system using a multi-priority strategy where several contact points are commanded in parallel.Multi-priority Cartesian impedance control is the natural combination of these two ideas.The system realizes several impedances with different reference positions at different points on the robot with a specified order of priority.We find a controller that minimizes an arbitrary quadratic norm on the second-priority impedance error subject to constraints deriving from the first priority impedance task.We also show that the locally optimal controller does not require force feedback in its implementation for passive desired inertias.The results are illustrated in simulation.
Intrinsic Activity Develops Along a Sensorimotor-Association Cortical Axis in Youth (2022)

ABSTRACT Animal studies of neurodevelopmental plasticity have shown that intrinsic brain activity evolves from high amplitude and globally synchronized to suppressed and sparse as plasticity declines and the cortex matures. Leveraging resting-state functional MRI data from 1033 individuals (8-23 years), we reveal that this stereotyped refinement of intrinsic activity occurs during human development and provides evidence for a cortical gradient of neurodevelopmental plasticity during childhood and adolescence. Specifically, we demonstrate that declines in the amplitude of intrinsic activity are initiated heterochronously across regions, coupled to the maturation of a plasticity-restricting structural feature, and temporally staggered along a hierarchical sensorimotor-association axis from ages 8 to 18. Youth from disadvantaged environments exhibit reduced intrinsic activity in regions further up the sensorimotor-association axis, suggestive of a reduced level of plasticity in late-maturing cortices. Our results uncover a hierarchical axis of neurodevelopment and offer insight into the temporal sequence of protracted neurodevelopmental plasticity in humans.
Reputation in Bargaining and Durable Goods Monopoly (1989)

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Monolithic 180 nm CMOS Dosimeter for In Vivo Medical Applications (2013)

The design and development of a monolithic system-on-chip silicon device for real time measurement of radiation dose is described. The device is fabricated in a standard 180 nm CMOS technology. The proposed application is in the medical field of In Vivo Dosimetry, where the dose of radiation, delivered to patients during radiotherapy sessions, is monitored in real time by an in-body implanted device of 1 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> approximate size and the related information is transmitted wirelessly to an external receiver operating in the Medical Implant Communication Service (MICS) band. Along with standard electrical characterization, evaluation of device performance is carried out under radiation beam in a clinical environment. The design and initial test results of the first phase of the project, covering the radiation sensors, will be discussed. A description of the next project steps will also be given.