gebhart/patrepeval huggingface dataset:
Administration of Interleukin 13 to Simian Immunodeficiency Virus-Infected Macaques: Induction of Intestinal Epithelial Atrophy (1998)

Increase Th2 cytokine production may contribute to some clinical manifestations of HIV infection, and studies have suggested that IL-13 rather than IL-4 is involved in these conditions. We directly tested this hypothesis by administrating IL-13 to SIV-infected macaques. SIV-infected rhesus macaques received a daily subcutaneous injection for 21 days of either IL-13 (10 microg/kg/day) or a placebo. The four macaques treated with IL-13 experienced body weight loss (9.95 +/- 0.71%) related to intestinal tract damage: they all suffered from a complete atrophy of duodenal villi. This was presumably due to premature epithelial cell death: proliferating Ki67+ cells in glandular crypts were as numerous as in control animals, but many epithelial cells developed apoptosis. The duodenal mucosa was infiltrated with cells expressing CD56 and PEN5, two markers of NK cells, and there was a deregulation of local cytokine and chemokine production characterized by a decrease in IL-10 gene expression (25% of controls) and an increase in gene expression for IFN-gamma (4-fold control), MIP-1alpha (8-fold control), and MIP-1beta (13-fold control). Thus, IL-13 can induce digestive epithelial cell injury in vivo in primates infected with a retrovirus. Therefore, its role should be considered in digestive manifestations of HIV infection as well as in other disorders associated with intestinal epithelial atrophy.
FLOX® Combustion at High Power Density and High Flame Temperatures (2010)

In this contribution, an overview of the progress in the design of an enhanced FLOX® burner is given. A fuel flexible burner concept was developed to fulfill the requirements of modern gas turbines: high specific power density, high turbine inlet temperature, and low NOx emissions. The basis for the research work is numerical simulation. With the focus on pollutant emissions a detailed chemical kinetic mechanism is used in the calculations. A novel mixing control concept, called HiPerMix®, and its application in the FLOX® burner is presented. In view of the desired operational conditions in a gas turbine combustor this enhanced FLOX® burner was manufactured and experimentally investigated at the DLR test facility. In the present work experimental and computational results are presented for natural gas and natural gas + hydrogen combustion at gas turbine relevant conditions and high adiabatic flame temperatures (up to Tad = 2000 K). The respective power densities are PA = 13.3 MW/m2/bar (NG) and PA = 14.8 MW/m2/bar (NG + H2) satisfying the demands of a gas turbine combustor. It is demonstrated that the combustion is complete and stable and that the pollutant emissions are very low.
Reimagining the Stadium Spectator Experience using Augmented Reality and Visual Positioning System (2022)

Professional sports clubs around the world have been looking for ways to innovate and engage fans with novel sports watching experiences at the stadium. Augmented reality is often used to offer an immersive and interactive experience at a specific place, connecting virtual artefacts with the physical location in meaningful ways. In this work, we introduce the practical use of Visual Positioning System, combined with our unique AR design, together with novel placement of content, interaction with live sports data, and linking them directly to e-commerce services on-demand to create a unique, immersive, and interactive sports watching experience at the stadium.
ChemInform Abstract: The Crystal Structure of 3,3′,5,5′,7‐Pentahydroxy‐4′‐methoxy‐2,3‐cis‐flavane Tetrahydrate. (1986)

Abstract Die Titelverbindung (I) kristallisiert in der RG P2 1 mit Z=4.
Developmental changes in cellular prion protein in primate visual cortex (2007)

Cellular prion protein (PrP(c)) is a cell surface glycoprotein highly expressed in neurons, and a protease-resistant conformer of the protein accumulates in the brain parenchyma in prion diseases. In human prion diseases, visual cortex and visual function can be affected. We examined both the levels and the localization of PrP(c) in developing visual cortex of the common marmoset. Western blot analysis showed that PrP(c) increased from the day of birth through adulthood, and this increase correlated with the progression of synapse formation. Immunohistochemistry showed that PrP(c) was present in fiber tracts of the neonate, and this immunoreactivity was lost with maturation. Within the neuropil, the laminar distribution of PrP(c) changed with age. In the neonate, PrP(c) immunoreactivity was strongest in layer 1, where the earliest synapses form. At the end of the first postnatal week, layer 4C, as identified by its strong cytochrome oxidase activity, was noticeably lighter in terms of PrP(c) immunoreactivity than the adjacent layers. The contrast between the strong immunoreactivity in both supragranular and infragranular layers and weak immunoreactivity in layer 4C increased with age. Layers 2/3 and 5 contained more intense PrP(c) immunoreactivity; these layers receive thalamic input from the koniocellular division of the LGN, and these layers of the LGN also had strong PrP(c) immunoreactivity. Together, these results provide evidence for PrP(c) localization in an identified functional pathway and may shed some light on prion disease pathogenesis.
Sostdc1 deficiency accelerates fracture healing by promoting the expansion of periosteal mesenchymal stem cells (2016)

Loss of Sostdc1, a growth factor paralogous to Sost, causes the formation of ectopic incisors, fused molars, abnormal hair follicles, and resistance to kidney disease. Sostdc1 is expressed in the periosteum, a source of osteoblasts, fibroblasts and mesenchymal progenitor cells, which are critically important for fracture repair. Here, we investigated the role of Sostdc1 in bone metabolism and fracture repair. Mice lacking Sostdc1 (Sostdc1(-/-)) had a low bone mass phenotype associated with loss of trabecular bone in both lumbar vertebrae and in the appendicular skeleton. In contrast, Sostdc1(-/-) cortical bone measurements revealed larger bones with higher BMD, suggesting that Sostdc1 exerts differential effects on cortical and trabecular bone. Mid-diaphyseal femoral fractures induced in Sostdc1(-/-) mice showed that the periosteal population normally positive for Sostdc1 rapidly expands during periosteal thickening and these cells migrate into the fracture callus at 3days post fracture. Quantitative analysis of mesenchymal stem cell (MSC) and osteoblast populations determined that MSCs express Sostdc1, and that Sostdc1(-/-) 5day calluses harbor >2-fold more MSCs than fractured wildtype controls. Histologically a fraction of Sostdc1-positive cells also expressed nestin and α-smooth muscle actin, suggesting that Sostdc1 marks a population of osteochondral progenitor cells that actively participate in callus formation and bone repair. Elevated numbers of MSCs in D5 calluses resulted in a larger, more vascularized cartilage callus at day 7, and a more rapid turnover of cartilage with significantly more remodeled bone and a thicker cortical shell at 21days post fracture. These data support accelerated or enhanced bone formation/remodeling of the callus in Sostdc1(-/-) mice, suggesting that Sostdc1 may promote and maintain mesenchymal stem cell quiescence in the periosteum.
Effect of Macrocycle Type on Pb2+ Transport through an Emulsion Liquid Membrane (1987)

Abstract The relative effectiveness of 14 different macro-cycles in transporting Pb(NO3)2 has been determined at 25 °C using a water-toluene-water emulsion membrane system. The largest amount of Pb2+ transport was found with dideeyl-1,1O-diaza-18-crown-6 (91%), followed by dicyclohexano-18-crown-6 (81%), di-tert-butyl-dicyclohexano-l8-crown-6 (77%), 1,10-diaza-18-crown-6 (27%), and cryptand 2.2.1 (4,7,13,16,21,24-pentoxa-1,10-diazabicyclo(8, 8, 5)-tricosane) (16%). The use of the other macrocycles produced little Pb2+ transport. Analysis of the transport results shows that, for most effective transport, the macrocycle should distribute preferentially to the organic phase and the log K value for the binding of the macrocycle with Pb2+ must be large enough for quantitative extraction of the Pb2 + into the membrane. However, this log K value must be sufficiently smaller than that for interaction of Pb2+ with P2O7 4−, the receiving phase complexing agent, to allow a large Pb2+ concentration gradient to be established. These features provide information which should be useful in designing systems for cation separations using emulsion membranes.
Identification and characterization of tyrosine kinase activity associated with mitochondrial outer membrane in sarcoma 180 cells (1988)

Tyrosine protein kinase activity has been detected in the mitochondrial fraction purified from sarcoma 180 tumor cells. Following hypotonic disruption of mitochondria, tyrosine kinase activity appeared to cosediment with monamine oxidase, marker enzyme of mitochondrial outer membrane; meanwhile, serine and threonine kinases were found to be associated with the inner membrane and matrix of mitochondria. Mitochondrial tyrosine kinase(s) showed thermosensitivity and Mn2+ dependence, useful properties for its characterization and separation from tyrosine kinases associated with other particulate fraction and from serine and threonine kinases associated with mitochondria. Following in vitro incubation of mitochondria with labelled ATP as substrate and analysis by PAGE, a complex pattern of phosphotyrosine containing proteins with a major band of 50-55 kilodaltons resulted.
Consequences of Anode Interfacial Layer Deletion. HCl-Treated ITO in P3HT:PCBM-Based Bulk-Heterojunction Organic Photovoltaic Devices (2009)

In studies to simplify the fabrication of bulk-heterojunction organic photovoltaic (OPV) devices, it was found that when glass/tin-doped indium oxide (ITO) substrates are treated with dilute aqueous HCl solutions, followed by UV ozone (UVO), and then used to fabricate devices of the structure glass/ITO/P3HT:PCBM/LiF/Al, device performance is greatly enhanced. Light-to-power conversion efficiency (Eff) increases from 2.4% for control devices in which the ITO surface is treated only with UVO to 3.8% with the HCl + UVO treatment--effectively matching the performance of an identical device having a PEDOT:PSS anode interfacial layer. The enhancement originates from increases in V(OC) from 463 to 554 mV and FF from 49% to 66%. The modified-ITO device also exhibits a 4x enhancement in thermal stability versus an identical device containing a PEDOT:PSS anode interfacial layer. To understand the origins of these effects, the ITO surface is analyzed as a function of treatment by ultraviolet photoelectron spectroscopy work function measurements, X-ray photoelectron spectroscopic composition analysis, and atomic force microscopic topography and conductivity imaging. Additionally, a diode-based device model is employed to further understand the effects of ITO surface treatment on device performance.
ChemInform Abstract: Identification of a Series of 1,2,3,4‐Tetrahydroisoquinolinyl Benzamides with Potential Anticonvulsant Activity. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Phase 2, Controlled, Dose-Ranging Study of SB208, an Investigational Topical Nitric Oxide-Releasing Drug, for the Treatment of Tinea Pedis. (2018)

Topical SB208 was effective and well tolerated in the treatment of tinea pedis. J Drugs Dermatol. 2018;17(8):888-893.
Prolonged duration local anesthesia with lipid–protein–sugar particles containing bupivacaine and dexamethasone (2005)

Glucocorticoids prolong block duration from polymeric microspheres containing bupivacaine, but not from unencapsulated drug. Here we investigate this effect applies to particles with much more rapid drug release and improved long-term biocompatibility. Male Sprague-Dawley rats were given sciatic nerve blocks with 75 mg of 3% or 60% (w/w) dipalmitoylphosphatidylcholine (DPPC) spray-dried lipid-protein-sugar particles (LPSPs) containing 10% (w/w) bupivacaine and 0%, 0.05%, or 0.1% (w/w) dexamethasone. Sensory nerve block from bupivacaine-containing 3% and 60% (w/w) DPPC particles without dexamethasone yielded blocks lasting 301 +/- 56 and 321 +/- 127 min, respectively. Addition of 0.05% (w/w) dexamethasone increased block durations to 610 +/- 182 and 538 +/- 222 min, respectively; increasing dexamethasone loading to 0.1% did not further increase duration. One day after injection, dexamethasone-containing particles resulted in lower inflammation scores and capsule thickness than dexamethasone-free particles, but the difference was gone by day 4. Excipient composition had prominent effects at all time points. For all groups, inflammation was largely resolved by 2 weeks after injection. Dexamethasone approximately doubled the duration of nerve block from bupivacaine-loaded LPSPs, while maintaining excellent biocompatibility. Such formulations could be useful in clinical applications when nerve blockade is needed for 24 hours or less.
Characterizing Ancylostoma caninum transcriptome and exploring nematode parasitic adaptation (2010)

This study validated the usage of deep sequencing for gene expression profiling. Parasitic adaptation of the canine hookworm is related to its diversity and developmental dynamics. This comprehensive comparative genomic and expression study substantially improves our understanding of the basic biology and parasitism of hookworms and, is expected, in the long run, to accelerate research toward development of vaccines and novel anthelmintics.
Frequency and distribution of deletions in dystrophin gene in Duchenne muscular dystrophy patients from an east-European Slavonic population. (1991)

In 32 unrelated DMD patients originating from Slovakia (Czechoslovakia), screening for deletions in the dystrophin gene was performed with cDNA probes Cf56a, Cf56b, 1-2a, 2b-3 4-5a, 5b-7, and 8. In 14 out of 32 DMD patients (43.75 per cent), a deletion extending from one to three adjacent probes was observed. The highest proportion of deletions was found with probes 8 and 1-2a (50 and 28.6 per cent of all deletions, respectively). All these proportions are similar to those found in other populations of European origin.
RNA and Protein: A Match Made in the Hadean (2014)

Presented on September 9, 2013 from 8:30 a.m.-9:30 a.m. at the Parker H. Petit Institute for Bioengineering &amp; Bioscience (IBB), room 1128, Georgia Tech.
ChemInform Abstract: Diastereoselectivity in the Boranate Reduction of α‐Triazolyl Ketones. (1988)

Abstract The boranate reduction of the triazolyl ketone (II) in the presence of TiCl 4 leads to a highly diastereoselective formation of the diastereomer (I) with anti orientation of the hydroxy and triazole groups, whereas the diastereomer (III) with the hydroxy and triazole groups syn to each other is formed in the absence of Lewis acid.
Supplementary Figures S1-S3 from Anti–Programmed Death-1 Synergizes with Granulocyte Macrophage Colony-Stimulating Factor–Secreting Tumor Cell Immunotherapy Providing Therapeutic Benefit to Mice with Established Tumors (2023)

Supplementary Figures S1-S3 from Anti–Programmed Death-1 Synergizes with Granulocyte Macrophage Colony-Stimulating Factor–Secreting Tumor Cell Immunotherapy Providing Therapeutic Benefit to Mice with Established Tumors
Coordinated Operation of Centrifugal Compressors in Series via Model Predictive Control (2016)

This paper investigates the control challenges in the operation of centrifugal compressors in series configuration, which arise from the interactions of the different control loops for process and anti-surge control. The investigation is carried out with simulations, where two compressors in series are considered to represent the simplest possible case for systems analysis. The simulations are based on a well-known nonlinear compressor model to represent the plant behavior as close to reality as possible. The paper starts with the derivation of linear transfer functions from step response analysis, which are used to develop both advanced decentralized control solutions using loop decoupling schemes as well as a model predictive controller (MPC). The various alternative control strategies are then investigated by introducing a typical downstream disturbance case that pushes the compressors towards surge conditions while creating interactions among all control loops. The simulation results are analyzed to determine the advantages and the shortcomings of the different control strategies. The MPC based approach stands out as a high performance alternative to traditional control schemes relying on simple feedback and feedforward elements.
Fudan University at TRECVID 2005 (2005)

In this notebook paper we describe our participation in the NIST TRECVID 2006 evaluation. We took part in two tasks of benchmark this year including high-level feature extraction and search (manual/interactive). For high-level feature extraction, we submitted 4 runs. FD_SVM_BN_1: using SVM and ontology. FD_SCM_BN_2: using GMM and ontology. FD_SVM_MTL_3: using SVM and multi-task learning. FD_SCM_MTL_4: using GMM and multi-task learning. Evaluation results illustrate that there are both advantages and disadvantages exist in all methods. For search, we submitted 3 manual runs and 1 interactive run. M_A_2_FD_M_TEXT_1: textual retrieval M_A_2_FD_MM_BC_3: multi-model, relation expression, BC fusion. M_A_2_FD_M_TRAIN_TEXT_2: textual retrieval, using key words trained by develop data. I_A_2_FD_I_LR_4: interactive run using LR regression Evaluation results illustrate that the method only using textual information is better than other runs. We also tried to select keywords by training develop data to get better performance. 1.
Preconcentration and detection of the phosphorylated forms of cardiac troponin I in a cascade microchip by cationic isotachophoresis (2011)

This paper describes the detection of a cardiac biomarker, cardiac troponin I (cTnI), spiked into depleted human serum using cationic isotachophoresis (ITP) in a 3.9 cm long poly(methyl methacrylate) (PMMA) microfluidic channel. The microfluidic chip incorporates a 100× cross-sectional area reduction, including a 10× depth reduction and a 10× width reduction, to increase sensitivity during ITP. The cross-sectional area reductions in combination with ITP allowed visualization of lower concentrations of fluorescently labeled cTnI. ITP was performed in both "peak mode" and "plateau mode" and the final concentrations obtained were linear with initial cTnI concentration. We were able to detect and quantify cTnI at initial concentrations as low as 46 ng mL(-1) in the presence of human serum proteins and obtain cTnI concentrations factors as high as ~ 9000. In addition, preliminary ITP experiments including both labeled cTnI and labeled protein kinase A (PKA) phosphorylated cTnI were performed to visualize ITP migration of different phosphorylated forms of cTnI. The different phosphorylated states of cTnI formed distinct ITP zones between the leading and terminating electrolytes. To our knowledge, this is the first attempt at using ITP in a cascade microchip to quantify cTnI in human serum and detect different phosphorylated forms.
Reducing the Bipolar Junction Transistor Vbe Non-Linearity (2019)

There is an increasing demand for high-performance, low-cost, small footprint and reliable silicon-based temperature sensors. Most of the high precision temperature sensors are based on Bipolar Junction Transistor (BJT). The base-emitter voltage of a BJT can be a good temperature sensor if the device to device distribution is compensated and its inherent nonlinearity is reduced. This paper proposes simple, low cost, high precision, low noise, temperature sensor. The base-emitter voltage variation and its non-linearity will be discussed, and the corresponding trimming will be presented.
Automatic 3D Indoor Scene Modeling from Single Panorama (2018)

We describe a system that automatically extracts 3D geometry of an indoor scene from a single 2D panorama. Our system recovers the spatial layout by finding the floor, walls, and ceiling; it also recovers shapes of typical indoor objects such as furniture. Using sampled perspective sub-views, we extract geometric cues (lines, vanishing points, orientation map, and surface normals) and semantic cues (saliency and object detection information). These cues are used for ground plane estimation and occlusion reasoning. The global spatial layout is inferred through a constraint graph on line segments and planar superpixels. The recovered layout is then used to guide shape estimation of the remaining objects using their normal information. Experiments on synthetic and real datasets show that our approach is state-of-the-art in both accuracy and efficiency. Our system can handle cluttered scenes with complex geometry that are challenging to existing techniques.
A Thermally Responsive Phospholipid Pseudogel: Tunable DNA Sieving with Capillary Electrophoresis (2013)

In an aqueous solution the phospholipids dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and 1,2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC) self-assemble to form thermo-responsive non-Newtonian fluids (i.e., pseudogels) in which small temperature changes of 5-6 °C decrease viscosity dramatically. This characteristic is useful for sieving-based electrophoretic separations (e.g., of DNA), as the high viscosity of linear sieving additives, such as linear polyacrylamide or polyethylene oxide, hinders the introduction and replacement of the sieving agent in microscale channels. Advantages of utilizing phospholipid pseudogels for sieving are the ease with which they are introduced into the separation channel and the potential to implement gradient separations. Capillary electrophoresis separations of DNA are achieved with separation efficiencies ranging from 400,000 to 7,000,000 theoretical plates in a 25 μm i.d. fused silica capillary. Assessment of the phospholipid pseudogel with a Ferguson plot yields an apparent pore size of ~31 nm. Under isothermal conditions, Ogston sieving is achieved for DNA fragments smaller than 500 base pairs, whereas reptation-based transport occurs for DNA fragments larger than 500 base pairs. Nearly single base resolution of short tandem repeats relevant to human identification is accomplished with 30 min separations using traditional capillary electrophoresis instrumentation. Applications that do not require single base resolution are completed with faster separation times. This is demonstrated for a multiplex assay of biallelic single nucleotide polymorphisms relevant to warfarin sensitivity. The thermo-responsive pseudogel preparation described here provides a new innovation to sieving-based capillary separations.