gebhart/patrepeval huggingface dataset:
Syngeneic Donor Hematopoietic Stem Cell Transplantation Is Associated with High Rates of Engraftment Syndrome (2010)

Abstract Abstract 1323 Engraftment syndrome (ES), typically characterized by non-infectious fever, rash and/or non-cardiogenic pulmonary edema, is a complication of autologous and allogeneic hematopoietic stem cell transplantation (HSCT). There is no data on ES after syngeneic HSCT. We retrospectively analyzed syngeneic HSCT outcomes and determined ES incidence, risk factors, and prognostic impact. 32 adult patients with a median age of 46 years (range, 22–60) underwent syngeneic HSCT at our institution between July 1986-April 2009, primarily for hematologic malignancies (31% myeloid, 66 % lymphoid-including 16% plasma cell). Syngeneic donor typing methods varied over the time-period of this report and included: serologic HLA Class I and II typing; confirmatory SSP molecular HLA Class I typing; molecular PCR-RFLP and SSP HLA Class II typing; and STR genotyping using ABI Profile Plus Kit Human Identity markers. Patient characteristics: 15 (47%) were male; 28 (88%) had high-risk disease; 18 (56%) received total-body irradiation (TBI) as a component of myeloablative conditioning; 16 (50%) received donor peripheral blood stem cell infusion; and 14 (41%), 10 (31%) and 9 (28%) had low-, intermediate- and high-risk HCT-comorbidity index score respectively. No graft-versus-host-disease prophylaxis, T-cell depletion, or pre-emptive or prophylactic donor lymphocyte infusion was utilized. The median duration of follow-up was 6.1 years (range, 3.7 months-18.1 years). 5-year progression-free and overall survival (PFS, OS) was 52% and 67% respectively. 5-year overall cumulative incidence of relapse and non-relapse mortality (NRM) was 37.6% and 10.2% respectively. 15 patients (47%) met diagnostic criteria for ES, 10 (67%) of whom received a brief course of systemic steroids with prompt clinical response in all except one patient (who died of respiratory failure). Patient age ≥50 years was a risk factor for developing ES (p=0.05). Median time to engraftment was 12 days in patients with ES vs. 11.5 days in those without ES. 5-year PFS was 47% in patients with ES vs. 56% in those without (p=0.37). 5-year OS was 63% with ES vs. 71% without (p=0.8). 5-year cumulative incidence of relapse was 32% with ES and 44% without (p=0.68). 5-year cumulative incidence of NRM was 21% with ES vs. 0% without (p=0.06). In multivariable Cox-models only myeloid diagnosis (vs. lymphoid) impaired PFS and OS (HR 4.83, 95% CI 1.33–17.53, p=0.02; HR 8.47, 95% CI 1.73–41.58, p&lt;0.01 respectively). In summary, we document a high incidence of ES after syngeneic HSCT. While syngeneic ES did not impact HSCT survival outcomes, the trend of increased NRM with ES is concerning and needs re-evaluation in a larger cohort.Figure:Cumulative Incidence of Relapse and NRM as Competing Risks-by ES cohortFigure:. Cumulative Incidence of Relapse and NRM as Competing Risks-by ES cohort Disclosures: No relevant conflicts of interest to declare.
Architecture considerations for 60 GHz wireless networks (2009)

Providing high data rates to wireless users has long been a goal that has driven the development of new technologies and standards in the past decade. Now, with the opening up of the spectrum at 60 GHz, it has become possible to design WLANs that can meet the goal of Gbps/user connectivity. This paper examines several unique design challenges brought about because of the physical characteristics of this frequency band. We show that antenna geometry has a significant impact on throughput. This result is obtained when we utilize realistic 3D beam patterns, rather than the common 2D approximation. Indeed, the maximum average throughput for a linear antenna array of 8 Gbps (using only 640 MHz of spectrum) is more than double that obtained with a circular array consisting of the same number of antenna elements. We explore the challenge of providing coverage in dead spots using the novel idea of passive reflectors.
Local suppression of Epstein-Barr virus (EBV)-specific cytotoxicity in biopsies of EBV-positive Hodgkin's disease (1995)

Epstein-Barr virus (EBV)-positive Hodgkin's and Reed-Sternberg (HRS) cells express the virus-encoded latent membrane proteins LMP1 and LMP2 that could serve as rejection targets in Hodgkin's disease (HD). To examine whether EBV-triggered reactivities can be detected in the tumor, we have compared cytokine mRNA expression, cell phenotype, and cytotoxic activity in biopsies from 8 EBV-carrying and 6 EBV-HD patients. Neither the pattern of lymphokine production nor the cell phenotype of the in vivo-activated interleukin-2-responding populations provided a clear discrimination between EBV+ and EBV- cases. HLA class I-restricted EBV-specific cytotoxicity was shown in interleukin-2-dependent cultures from 3 of 3 EBV- tumors, whereas cultures from 6 of 6 EBV+ tumors were either noncytotoxic or exerted LAK-type cytotoxicity. EBV-specific cytotoxic T lymphocyte precursors were present in the blood of 1 patient carrying an EBV+ tumor. The results suggest that a tumor-associated suppression of EBV-specific T-cell responses may play an important role in the pathogenesis of EBV+ HD.
Abnormal Proliferation and Defective Multilineage differentiation Potential of Adipose‐Derived Stem Cells Isolated from Dystrophin and Utrophin Knockout Mice (2012)

Adipose derived stem cells (ADSCs) hold potential in cell therapy for a variety of musculoskeletal injuries and diseases including Duchenne Muscular Dystrophy (DMD). DMD is a genetic disease characterized by progressive weakening of the skeletal, cardiac, and diaphragmatic muscles. Using double knock‐out mice (dKO) for dystrophin and utrophin which is a DMD model that better emulates the human phenotype of the disease in mice, we determine if ADSCs from dKO mice are affected in their proliferation and differentiation capacities compared to wild type (WT) ADSCs. ADSCs were isolated from fat tissue of 6 week old dKO‐homo (dys−/−utro−/−), dKO‐hetero (dys−/−utro+/−) and C57BL WT mice and flow cytometry was used to confirm positive expressions of Sca‐1, CD34, CD44 and CD29. Cell proliferation and apoptotic rates investigated using a Live Cell Imaging system showed dKO ADSCs have a higher proliferation rate than WT cells. This may explain the gradual muscle weakness and pseudohypertrophy observed in DMD. Myogenesis, adipogenesis and chondrogenesis are impaired in dKO ADSCs. Impaired myogenesis observed with dKO cells may be a secondary effect of the increased proliferation observed with those cells. These results suggest a dysfunction in the dKO ADSCs and that blocking the exhaustion of ADSCs and stem cell therapy could be used to modulate adipose tissue formation in the muscles of DMD patients to restore structure and function. Grant Funding Source : NIH
Non Data-Aided Carrier Tracking Techniques for Continuous-Phase Frequency-Shift Keyed Signals (2025)

Communications between ground stations and nanosats in low earth orbit (LEO) require acquisition and tracking of large Doppler frequency offsets due to the relative velocity between the transmitter and the receiver. The Doppler frequency shift varies with time, reaching its fastest rate of change as the small satellite reaches its closest approach to the ground station. For phase modulated signals, a frequency offset estimate extracted from the band edge filters is used to correct for the Doppler shift. This approach encounters difficulties when it’s used to correct for frequency offset in continuous phase frequency shift keyed (CPFSK) signals. Optimized band edge filters are designed to have a frequency response that is the derivative of the matched filter frequency response. However, CPFSK detection often requires different matched filters for different symbols, particularly when there are multiple possible magnitudes of frequency shifts to choose from in each symbol period. Having separate matched filters for different symbols complicates the effort to use optimized band edge filters as it imposes a requirement to demodulate the signal before correcting its frequency offset. Furthermore, the fact that the signal of interest is itself changing in frequency from one symbol to the next further complicates the issue. However, a modification to the classic band edge filter design can permit the detection and correction of CPFSK signals without the need to demodulate the signal. This paper presents techniques for non data-aided correction of CPFSK signals using modified matched filters in frequency locked loops (FLLs). Examples of the approaches are shown in MATLAB for varying signal-to-noise ratio (SNR), static Doppler, and dynamic Doppler.
Advanced deep learning methodologies for skin cancer classification in prodromal stages (2019)

Technology-assisted platforms provide reliable solutions in almost every field these days. One such important application in the medical field is the skin cancer classification in preliminary stages that need sensitive and precise data analysis. For the proposed study the Kaggle skin cancer dataset is utilized. The proposed study consists of two main phases. In the first phase, the images are preprocessed to remove the clutters thus producing a refined version of training images. To achieve that, a sharpening filter is applied followed by a hair removal algorithm. Different image quality measurement metrics including Peak Signal to Noise (PSNR), Mean Square Error (MSE), Maximum Absolute Squared Deviation (MXERR) and Energy Ratio/ Ratio of Squared Norms (L2RAT) are used to compare the overall image quality before and after applying preprocessing operations. The results from the aforementioned image quality metrics prove that image quality is not compromised however it is upgraded by applying the preprocessing operations. The second phase of the proposed research work incorporates deep learning methodologies that play an imperative role in accurate, precise and robust classification of the lesion mole. This has been reflected by using two state of the art deep learning models: Inception-v3 and MobileNet. The experimental results demonstrate notable improvement in train and validation accuracy by using the refined version of images of both the networks, however, the Inception-v3 network was able to achieve better validation accuracy thus it was finally selected to evaluate it on test data. The final test accuracy using state of art Inception-v3 network was 86%.
Restoration of KCC2 Membrane Localization in Striatal Dopamine D2 Receptor-Expressing Medium Spiny Neurons Rescues Locomotor Deficits in HIV Tat-Transgenic Mice (2021)

People infected with HIV (PWH) are highly susceptible to striatal and hippocampal damage. Motor and memory impairments are common among these patients, likely as behavioral manifestations of damage to these brain regions. GABAergic dysfunction from HIV infection and viral proteins such as transactivator of transcription (Tat) have been well documented. We recently demonstrated that the neuron specific Cl<sup>-</sup> extruder, K<sup>+</sup> Cl<sup>-</sup> cotransporter 2 (KCC2), is diminished after exposure to HIV proteins, including Tat, resulting in disrupted GABA<sub>A</sub>R-mediated hyperpolarization and inhibition. Here, we utilized doxycycline (DOX)-inducible, GFAP-driven HIV-1 Tat transgenic mice to further explore this phenomenon. After two weeks of Tat expression, we found no changes in hippocampal KCC2 levels, but a significant decrease in the striatum that was associated with hyperlocomotion in the open field assay. We were able to restore KCC2 activity and baseline locomotion with the KCC2 enhancer, CLP290. Additionally, we found that CLP290, whose mechanism of action has yet to be described, acts to restore phosphorylation of serine 940 resulting in increased KCC2 membrane localization. We also examined neuronal subpopulation contributions to the noted effects and found significant differences. Dopamine D2 receptor-expressing medium spiny neurons (MSNs) were selectively vulnerable to Tat-induced KCC2 loss, with no changes observed in dopamine D1 receptor-expressing MSNs. These results suggest that disinhibition/diminished hyperpolarization of dopamine D2 receptor-expressing MSNs can manifest as increased locomotion in this context. They further suggest that KCC2 activity might be a therapeutic target to alleviate motor disturbances related to HIV.
Tic22 Is Targeted to the Intermembrane Space of Chloroplasts by a Novel Pathway (1999)

Tic22 previously was identified as a component of the general import machinery that functions in the import of nuclear-encoded proteins into the chloroplast. Tic22 is peripherally associated with the outer face of the inner chloroplast envelope membrane, making it the first known resident of the intermembrane space of the envelope. We have investigated the import of Tic22 into isolated chloroplasts to define the requirements for targeting of proteins to the intermembrane space. Tic22 is nuclear-endoded and synthesized as a preprotein with a 50-amino acid N-terminal presequence. The analysis of deletion mutants and chimerical proteins indicates that the precursor of Tic22 (preTic22) presequence is necessary and sufficient for targeting to the intermembrane space. Import of preTic22 was stimulated by ATP and required the presence of protease-sensitive components on the chloroplast surface. PreTic22 import was not competed by an excess of an authentic stromal preprotein, indicating that targeting to the intermembrane space does not involve the general import pathway utilized by stromal preproteins. On the basis of these observations, we conclude that preTic22 is targeted to the intermembrane space of chloroplasts by a novel import pathway that is distinct from known pathways that target proteins to other chloroplast subcompartments.
Device for Insertion of Subcutaneous Under-arm Contraceptive Implants (2013)

Executive Summary of ME 450 F13 Team 3 Final Report
Maguro, a system for indexing and searching over very large text collections (2013)

Maguro is a system for efficiently searching very large collections of text content of up to 1 trillion documents at low cost. Search engines span across content that is very dynamic and highly augmented with metadata to the tail content of the web. A long tail distribution of content calls for different trade-offs in the design space for good efficiency across the entire index range. Maguro is designed for the long tail of content with less dynamics and less metadata, but very good cost efficiency. Maguro is part of the serving stack in Bing and allows us to scale the index significantly better.
Beyond accountability (2013)

Recently, the importance of including obligations as part of access control systems for privilege management, for example, in healthcare information systems, has been well recognized. In an access control system, an a posteriori obligation states which actions need to be performed by a user after he has accessed a resource. There is no guarantee that a user will fulfill a posteriori obligations. Not fulfilling these obligations may incur financial loss, or loss of goodwill and productivity to the organization. In this paper, we propose a trust-and-obligation based framework that reduces the risk exposure of an organization associated with a posteriori obligations. We propose a methodology to assign trust values to users to indicate how trustworthy they are with regards to fulfilling their obligations. When access requests that trigger a posteriori obligations are evaluated, the requesting users' trust values and the criticality of the associated obligations are used. Our framework detects and mitigates insider attacks and unintentional damages that may result from violating a posteriori obligations. Our framework also provides mechanisms to determine misconfigurations of obligation policies. We evaluate our framework through simulations and demonstrate its effectiveness.
Integrative taxonomy justifies a new genus, Nodastrella gen. nov., for North Atlantic " Rossella " species (Porifera: Hexactinellida: Rossellidae) (2012)

Dohrmann, Martin, Göcke, Christian, Reed, John, Janussen, Dorte (2012): Integrative taxonomy justifies a new genus, Nodastrella gen. nov., for North Atlantic " Rossella " species (Porifera: Hexactinellida: Rossellidae). Zootaxa 3383: 1-13, DOI: 10.5281/zenodo.281727
Discovery of Dual Inducible/Neuronal Nitric Oxide Synthase (iNOS/nNOS) Inhibitor Development Candidate 4-((2-Cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) Part 2: Identification of a Novel, Potent, and Selective Series of Benzimidazole-Quinolinone iNOS/nNOS Dimerization Inhibitors That Are Orally Active in Pain Models (2010)

Three isoforms of nitric oxide synthase (NOS), dimeric enzymes that catalyze the formation of nitric oxide (NO) from arginine, have been identified. Inappropriate or excessive NO produced by iNOS and/or nNOS is associated with inflammatory and neuropathic pain. Previously, we described the identification of a series of amide-quinolinone iNOS dimerization inhibitors that although potent, suffered from high clearance and limited exposure in vivo. By conformationally restricting the amide of this progenitor series, we describe the identification of a novel series of benzimidazole-quinolinone dual iNOS/nNOS inhibitors with low clearance and sustained exposure in vivo. Compounds were triaged utilizing an LPS challenge assay coupled with mouse and rhesus pharmacokinetics and led to the identification of 4,7-imidazopyrazine 42 as the lead compound. 42 (KD7332) (J. Med. Chem. 2009, 52, 3047 - 3062) was confirmed as an iNOS dimerization inhibitor and was efficacious in the mouse formalin model of nociception and Chung model of neuropathic pain, without showing tolerance after repeat dosing. Further 42 did not affect motor coordination up to doses of 1000 mg/kg, demonstrating a wide therapeutic margin.
Capacity Bounds for One-Bit MIMO Gaussian Channels with Analog Combining (2022)

The use of 1-bit analog-to-digital converters (ADCs) is seen as a promising approach to significantly reduce the power consumption and hardware cost of multiple-input multiple-output (MIMO) receivers. However, the nonlinear distortion due to 1-bit quantization fundamentally changes the optimal communication strategy and also imposes a capacity penalty to the system. In this paper, the capacity of a Gaussian MIMO channel in which the antenna outputs are processed by an analog linear combiner and then quantized by a set of zero threshold ADCs is studied. A new capacity upper bound for the zero threshold case is established that is tighter than the bounds available in the literature. In addition, we propose an achievability scheme which configures the analog combiner to create parallel Gaussian channels with phase quantization at the output. Under this class of analog combiners, an algorithm is presented that identifies the analog combiner and input distribution that maximize the achievable rate. Numerical results are provided showing that the rate of the achievability scheme is tight in the low signal-to-noise ratio (SNR) regime. Finally, a new 1-bit MIMO receiver architecture which employs analog temporal and spatial processing is proposed. The proposed receiver attains the capacity in the high SNR regime.
Supplementary Figure S2 from A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors (2023)

&lt;p&gt;Supplementary Figure S2 - PDF file 1676K, Induction of cell death and decreased proliferation following imipramine and promethazine treatment&lt;/p&gt;
Sehr kurze C‐C‐Einfachbindungen und ihre Ursache; die Länge der zentralen Bindung in Bitetrahedryl (1989)

Ein kleinerer C‐C‐Abstand und zugleich eine niedrigere Rotationsbarriere , das sind laut ab‐initio‐Rechnungen an Ethan die Folgen einer Vergrößerung des H‐C‐C‐Winkels. Daher ist in Verbindungen wie Bicubyl mit „zurückgebogenen”︁ Substituenten an der zentralen C–C‐Bindung diese Bindung viel kürzer als eine normale C‐C‐Einfachbindung. Da die Winkelvergrößerung eine Rehybridisierung mit einem höheren s‐Charakter der C–C‐Bindung bewirkt, kann die Bindung in Bitetrahedryl (berechnete Länge 1.438 Å) bezüglich der Hybridisierung mit der C‐C‐Einfachbindung in Butadiin (1.384 Å) verglichen werden.
Optical Assessment of Soft Contact Lens Edge‐Thickness (2016)

The results confirmed the ability of GD-OCM to provide high-definition images of soft contact lens edges. As a nondestructive, precise, and fast metrology tool for soft contact lens measurement, the integration of GD-OCM in the design and manufacturing of contact lenses will be beneficial for further improvement in edge design and quality control. In the clinical perspective, the in vivo evaluation of the lens fitted onto the cornea will advance our understanding of how the edge interacts with the ocular surface. The latter will provide insights into the impact of long-term use of contact lenses on the visual performance.
Figure S6 from UGT2B17 Expedites Progression of Castration-Resistant Prostate Cancers by Promoting Ligand-Independent AR Signaling (2023)

&lt;p&gt;Figure S6: UGT2B17 enhances VCaP cell growth and invasion after prolonged androgen deprivation&lt;/p&gt;
ChemInform Abstract: HYDRIDE SPONGE: 1,8‐NAPHTHALENEDIYLBIS(DIMETHYLBORANE) (1985)

Abstract Durch Reaktion von lß‐Dilithionaphthalin (dargestellt aus dem 1,8‐Diiododerivat und BuLi, Et2O, l0 min, 0 °C) mit einer etherischen Lösung von MeZB‐O‐Et (‐ 70 bis + 10°C) wurde die Titelverbindung (I) nach Aufarbeitung isoliert.
An Efficient Inductive Rectifier Based Piezo-Energy Harvesting Using Recursive Pre-Charge and Accumulation Operation (2022)

Inductor-based rectifiers have been developed to overcome the limitations of the traditional diode-based rectifiers for piezo-energy harvesting (PEH). This article proposes a new efficient method for extracting power from the piezoelectric transducer using the inductive rectifier. In the proposed method, the internal capacitance of the transducer is initially pre-charged, and the generated charges in response to the mechanical vibration are accumulated on the capacitor. When the accumulated voltage reaches a maximum allowed value ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$V_{\mathrm {MAX}}$ </tex-math></inline-formula> ), the total energy stored in the capacitor is transferred to the output, and the process is repeated. The proposed method ensures that the voltage swing across the transducer is always maximum for extracting the highest possible output power for given CMOS technology. The operational steps are self-timed, and the negative voltage swing across the transducer is avoided. The proposed inductive rectifier is realized using the buck–boost power stage of the DC energy-harvesting system for enabling efficient multi-source harvesting. Test chip is fabricated in the 180-nm CMOS technology, having a <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$V_{\mathrm {MAX}}$ </tex-math></inline-formula> of 3.3 V. The proposed rectifier extracts power in a single stage, even at a lower rectified output voltage <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\le $ </tex-math></inline-formula> 1 V. For a piezo open-circuit voltage of 1 V, the proposed rectifier extracts 3.68 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\times $ </tex-math></inline-formula> more power than the maximum output power of a full-bridge rectifier with ideal diodes. This is despite the voltage loss occurring during accumulation in the power stage implementation.