gebhart/patrepeval huggingface dataset:
The effect of augmenting suture material with magnesium and platelet-rich plasma on the in vitro adhesion and proliferation potential of subacromial bursa-derived progenitor cells (2023)

Augmenting suture material with Mg resulted in a significantly increased cellular adhesion of SBDCs compared to untreated suture material, as well as augmentation with PRP alone or a combination of both adjuvants. Further, Mg with or without PRP augmentation achieved a significant increase in the cellular proliferation of SBDCs on suture material compared to untreated sutures and augmentation with PRP alone. Application of Mg may be a clinically feasible approach to optimizing the use of SBDCs as a biological augment in rotator cuff repair, while combined augmentation with PRP may harness the full potential for optimized tissue recovery due to the high concentration of PRP-derived growth factors.
Extreme-Ultraviolet Vortices from a Free-Electron Laser (2017)

Extreme-ultraviolet vortices may be exploited to steer the magnetic properties of nanoparticles, increase the resolution in microscopy, and gain insight into local symmetry and chirality of a material; they might even be used to increase the bandwidth in long-distance space communications. However, in contrast to the generation of vortex beams in the infrared and visible spectral regions, production of intense, extremeultraviolet and x-ray optical vortices still remains a challenge. Here, we present an in-situ and an ex-situ technique for generating intense, femtosecond, coherent optical vortices at a free-electron laser in the extreme ultraviolet. The first method takes advantage of nonlinear harmonic generation in a helical undulator, producing vortex beams at the second harmonic without the need for additional optical elements, while the latter one relies on the use of a spiral zone plate to generate a focused, micron-size optical vortex with a peak intensity approaching 10 14 W=cm 2 , paving the way to nonlinear optical experiments with vortex beams at short wavelengths.
[Calcium antagonists and endothelial function]. (2005)

Endothelial dysfunction is an early sign of atherosclerosis. Patients with risk factors for atherosclerosis (e.g., hypertension, hyperlipidemia and diabetes mellitus) often show endothelial dysfunction at early stages of atherosclerosis before cardiovascular complications develop. Clinical studies and basic researches are revealing that calcium antagonists not only protect the endothelium through their hypotensive action but also improve the endothelial function through the stimulation of NO production. Regarding the mechanism for this kind of action by nifedipine (a calcium antagonist), it seems likely that the drug stimulates SOD expression in endothelial cells through enhanced VEGF expression by vascular smooth muscle cells, and thus reduces oxidative stress, leading to increased NO production.
Complexity reduction of blind decoding schemes using CRC splitting (2012)

Blind decoding, used on control channels of some multi-user wireless access systems, is a technique for achieving adaptive modulation and coding. The idea is to adapt the modulation and coding scheme to the channel quality but instead of signaling the parameters used explicitly, the receiver blindly tries a number of fixed parameter combinations until a successful decoding attempt is detected, with the help of a cyclic redundancy check. In this paper we suggest a new method for reducing the complexity and energy consumption associated with such blind decoding schemes. Our idea is to use a mini-CRC injected early in the data stream to determine if the current decoding attempt is using the correct modulation and coding parameters. We analyze and exemplify the complexity gain of this approach and also investigate the impact of the rearrangement of the CRC scheme in terms of the probability of undetected error. The presented results for the complexity gain are promising and the impact on the error detection capability turns out to be small if any.
Heavy-atom quenching of monomer and excimer pyrene fluorescence (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHeavy-atom quenching of monomer and excimer pyrene fluorescenceJ. M. G. MartinhoCite this: J. Phys. Chem. 1989, 93, 18, 6687–6692Publication Date (Print):September 1, 1989Publication History Published online1 May 2002Published inissue 1 September 1989https://pubs.acs.org/doi/10.1021/j100355a024https://doi.org/10.1021/j100355a024research-articleACS PublicationsRequest reuse permissionsArticle Views876Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Lymphotoxin Signals from Positively Selected Thymocytes Regulate the Terminal Differentiation of Medullary Thymic Epithelial Cells (2010)

The thymic medulla represents a key site for the induction of T cell tolerance. In particular, autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) provide a spectrum of tissue-restricted Ags that, through both direct presentation and cross-presentation by dendritic cells, purge the developing T cell repertoire of autoimmune specificities. Despite this role, the mechanisms of Aire(+) mTEC development remain unclear, particularly those stages that occur post-Aire expression and represent mTEC terminal differentiation. In this study, in mouse thymus, we analyze late-stage mTEC development in relation to the timing and requirements for Aire and involucrin expression, the latter a marker of terminally differentiated epithelium including Hassall's corpuscles. We show that Aire expression and terminal differentiation within the mTEC lineage are temporally separable events that are controlled by distinct mechanisms. We find that whereas mature thymocytes are not essential for Aire(+) mTEC development, use of an inducible ZAP70 transgenic mouse line--in which positive selection can be temporally controlled--demonstrates that the emergence of involucrin(+) mTECs critically depends upon the presence of mature single positive thymocytes. Finally, although initial formation of Aire(+) mTECs depends upon RANK signaling, continued mTEC development to the involucrin(+) stage maps to activation of the LTα-LTβR axis by mature thymocytes. Collectively, our results reveal further complexity in the mechanisms regulating thymus medulla development and highlight the role of distinct TNFRs in initial and terminal differentiation stages in mTECs.
Functional plasticity and recurrent cell states of malignant B cells in follicular lymphoma (2022)

ABSTRACT Follicular lymphoma (FL) derives from malignant transformation of germinal center (GC) B cells. FL malignant B cells are heterogeneous and diverge from their GC B cell-of-origin, but the diversity, function, and location of malignant B cell states remain to be addressed. Based on integrative single-cell RNA-seq, we identified and studied recurrent FL malignant B cell states and dynamics. Most FL B cells spanned a continuum of states from proliferating GC-like to quiescent memory (Mem)-like cell states. That GC-to-Mem axis was the main source of intra-tumor transcriptional heterogeneity. While FL B cell states were independent from subclonal B cell receptor genetics divergence, T follicular helper (T FH ) cell-derived signals controlled the transition from Mem-like to GC-like states. GC-like, T FH -activated and Mem-like FL B cells tended to occupy distinct niches within and around tumor follicles. Our study characterizes novel malignant cell states recurrent in B cell lymphomas, and highlights the functional plasticity of malignant B cells.
Fabrication of High Q Microdisk Resonators using Thermal Nanoimprint Lithography (2010)

International audience
Hot-spot analysis of motorcyclist crashes involving fixed objects using multinomial logit and data mining tools (2021)

There has been a significant increase in the number of motorcyclists in the past years. According to crash statistics, motorcyclist crashes involving roadside fixed objects and safety systems have a higher probability of resulting in a fatality and serious injury. Therefore, as the number of motorcyclists on the road increases, there is an urgent need to consider motorcyclist safety as an important factor when designing roadside safety systems. In this paper, we are developing a hot-spot detection methodology to identify the design characteristics of locations associated with severe motorcyclist crashes for improving roadside safety systems. For this purpose, we are using the multinomial logistic regression and data mining tools such as random forests and decision trees. The results of both data mining and regression analysis show that roadside safety devices and fixed objects have a significant impact on RwD motorcyclist crash severity. Additionally, roadway characteristics (horizontal and vertical curvature, lane width, urban-rural classification) and operational factors (traffic volume and posted speed limit) are found to be associated with the RwD motorcyclist crash severity. Hence, to identify the high-risk locations (i.e., locations with potential for improvement), these roadway elements need to be accounted for.
Tumor contact length: A novel multiparametric MRI predictor of prostate cancer outcomes. (2016)

61 Background: Multiparametric MRI (MP-MRI) can visualize prostate tumors. MP-MRI characteristics (extraprostatic extension (ECE), tumor volume, etc.) can be predictive of final pathologic findings such as lymph node (LN) involvement, pathological ECE (pECE), and biochemical recurrence (BCR). These are pivotal in the decision-making process regarding treatment. Tumor contact length (TCL) is defined as the length of cancer in contact with the prostatic capsule. We evaluated the ability of MP-MRI determined TCL in predicting pECE, BCR and LN in patients undergoing radical prostatectomy. Methods: All patients who underwent a 3T MP-MRI at the NCI from 2007 to 2015 were retrospectively classed into no ECE, suspicious ECE (sECE) and frank ECE (fECE) based on MP-MRI findings. sECE was defined as tumor with capsular bulge on MRI while fECE was clear capsular obliteration and tumor extension beyond the prostatic capsule. Demographic data was obtained on patients with fECE and sECE on MP-MRI with the presence of pECE, LN, and BCR status following radical prostatectomy from a single surgeon (PP) experience. Chi-Square and Wilcoxon rank sum test were used to compare proportions and continuous variables respectively. Logistic regression was used to determine the predictive ability of TCL. Statistical significance was defined as p-value ≤0.05. Results: Of all 1,260 patients who underwent MP-MRI, we focused on 146 who had sECE (68) or fECE (78) on MP-MRI. Mean age was 60 years and median prostate specific antigen was 11.7 ng/ml. Logistic regression analysis showed that MP-MRI determined TCL was predictive of ECE (p=0.01), LN status (p=0.0001) on final pathology and BCR (p=0.05) during follow up. Patients with pECE had a longer median MP-MRI TCL (2.8 cm) compared to those without pECE (2.4 cm), p=0.04. When analyzed individually, fECE correlated with pECE (p=0.05) while s ECE did not correlate with pECE (p=0.11). Although, not statistically significant, the median MP-MRI TCL for sECE with pECE was still longer than in sECE with no pECE in the sub-group analysis. Conclusions: Longer TCL on MP-MRI can indicate presence of ECE, LN involvement at final pathology as well as predict BCR on follow up.
Output feedback non-linear harmonic control of an industrial electric vehicle battery charger (2017)

For complying with power distributor regulation, the electric car chargers have to address the line current harmonic mitigation problem. The conventional solution is a proportional integral controller on the rectified current with a feed-forward anticipation action on the input network current. In this work we take advantage of a harmonic description of the electric car charger in order to propose a non-linear output feedback control based on sliding mode approach and Kalman filtering. The performance of the proposed control strategy is demonstrated via simulations realised in Matlab SimPowerSystems.
Protection of Lithium (Li) Anodes Using Dual Phase Electrolytes (2014)

Sion Power focused on metallic lithium anode protection, employing the Dual-Phase Electrolyte approach. The objective of this project was to develop a unique electrolyte providing two liquid phases having good Li+ conductivity, self-partitioning and immiscibility, serving separately the cathode and anode electrodes. This Dual-Phase Electrolyte was combined with thin film multi-layer, physical barrier membranes developed partially under a separate ARPA-E funded project. All these protective structures were stabilized by externally applied pressure. This strategy was used for Li-S cells. The development directly addressed cell safety, particularly higher thermal stability, while also allowing higher energies and cycle life. Safety tests showed that 100% of cells with Dual-Phase Electrolyte were intact and did not exhibit thermal runaway up to 178 °C and thus met the project objective of increasing the runaway temperature to >165°C. Cells also passed cycling at USABC Dynamic Stress Test conditions developed for Electric Vehicle applications and generated specific energy > 300 Wh/kg.
Angiopoietin 1 prevents retinal detachment in an aggressive model of proliferative retinopathy, but has no effect on established neovascularization (2005)

Vascular endothelial growth factor (VEGF) plays a central role in vasoproliferative diseases in the retina, however, other gene products modulate its effects. The angiopoietins are particularly important in this regard. Angiopoietin 2 (Ang2) collaborates with VEGF to stimulate neovascularization (NV) in some situations, but in other situations causes regression of NV. Ang2 also causes a transient increase in vascular density during retinal vascular development. In this study, we sought to determine if Ang1 has similar activities. The effects of Ang1 were tested in double transgenic mice with inducible expression of Ang1. Increased expression of Ang1 in the retina during retinal vascular development did not cause a detectable alteration in vascular density. Also, unlike Ang2, increased expression of Ang1 had no effect on established retinal or choroidal NV. However, when Ang1 expression was initiated simultaneously with that of VEGF, it strongly suppressed VEGF-induced NV and prevented retinal detachment. These data indicate that the timing of Ang1 expression is a critical determinate of its effects on VEGF-induced NV in the retina; it effectively blocks the initiation and progression of NV, but cannot reverse established NV or reduce leakage from NV. These data suggest that increased expression of Ang1 may be a good strategy for prophylaxis of retinal NV, but is unlikely to be effective as monotherapy of established NV.
A Study of the Virulence Traits of Carbapenem-Resistant Klebsiella pneumoniae Isolates in a Galleria mellonella Model (2019)

The increasing incidence of carbapenem-resistant <i>Klebsiella pneumoniae</i> (CRKP) strains is considered as a terrifying public health concern. This study target was to gain a further insight into the virulence traits of CRKP isolates in Egypt. The study was carried out by using 43 clinical <i>K. pneumoniae</i> isolates. Antibiotic susceptibility testing, biofilm formation assay, and molecular characterization of carbapenemase and virulence genes were done for all isolates. In addition, the genotypic relationship between CRKP isolates was identified by using enterobacterial repetitive intergenic consensus-polymerase chain reactions (ERIC-PCRs). A <i>Galleria mellonella</i> survival assay was adopted for <i>in vivo</i> testing of virulence of the CRKP. Carbapenem resistance was exhibited among 58% (25/43) isolates. Minimum inhibitory concentration values of carbapenem-resistant <i>K. pneumoniae</i> (CRKP) ranged from 32 to 128 μg/mL. Biofilm assay has revealed that 21 isolates (49%) had moderate biofilm formation and 11 isolates (25.5%) were strong biofilm producers. <i>Bla</i><sub>NDM-1</sub> was recognized in 20.9% (9<b>/</b>43) of the isolates, while <i>bla</i><sub>OXA-48</sub> was observed in 18.5% (8/43). Type 3 fimbriae (<i>mrkD</i>) and <i>entB</i> were addressed among 72.1% and 62.8% of <i>K. pneumoniae</i> isolates, respectively. The <i>ybtS</i> and <i>iutA</i> genes were detected among 44.2% and 37.2% of the isolates, respectively. ERIC-PCR showed 23 genetic profiles among CRKP isolates. CRKP biofilm producers were virulent according to the <i>G. mellonella</i> model, which indicates the importance of biofilm as a virulence trait among CRKP. This study indicates the emergence of CRKP with increased virulence traits, especially biofilm formation, in Egypt. This alarming report highlights the ongoing need for effective screening procedures and strict infection control measures.
Artificial intelligence directed development of a digital twin to measure soft tissue shift during head and neck surgery (2023)

Abstract Introduction Digital twins derived from 3D scanning data were developed to measure soft tissue deformation in head and neck surgery by an artificial intelligence approach. This framework was applied suggesting feasibility of soft tissue shift detection as a hitherto unsolved problem. Methods In a pig head cadaver model 104 soft tissue resection had been performed. The surface of the removed soft tissue (RTP) and the corresponding resection cavity (RC) was scanned (N=416) to train an artificial intelligence (AI) with two different 3D object detectors (HoloLens 2; ArtecEva). An artificial tissue shift (TS) was created by changing the tissue temperature from 7,91±4,1°C to 36,37±1,28°C. Results Digital twins of RTP and RC in cold and warm conditions had been generated and volumes were calculated based on 3D surface meshes. Significant differences in number of vertices created by the different 3D scanners (HoloLens2 51313 vs. ArtecEva 21694, p&lt;0.0001) hence result in differences in volume measurement of the RTC (p=0.0015). A significant TS could be induced by changing the temperature of the tissue of RC (p=0.0027) and RTP (p=&lt;0.0001). RC showed more correlation in TS by heating than RTP with a volume increase of 3.1 μl or 9.09% (p=0.449). Conclusions Cadaver models are suitable for training a machine learning model for deformable registration through creation of a digital twin. Despite different point cloud densities, HoloLens and ArtecEva provide only slightly different estimates of volume. This means that both devices can be used for the task.TS can be simulated and measured by temperature change, in which RC and RTP react differently. This corresponds to the clinical behaviour of tumour and resection cavity during surgeries, which could be used for frozen section management and a range of other clinical applications.
Scalable human-in-the-loop decision support (2015)

A scalable human-in-the-loop decision support system has been built around an active learning algorithm operating on aircraft engine time series data. The system integrates hierarchical clustering and active learning algorithms backed by a big data analytics ecosystem with a browser-based user interface. This combination enables multiple expert users to efficiently train a model to classify aircraft engine behavior by prioritizing the segments of flight for human analysis. This system lowers the time required from human experts by eliminating unnecessary labelling effort and supporting the aircraft maintenance industry's service technicians.
Astrocyte – microglial association and matrix deposition define common pathogenic events in primary familial brain calcification (2019)

Primary Familial Brain Calcification (PFBC) is an age-dependent and rare neurodegenerative disorder characterized by microvascular calcium phosphate deposits in deep brain regions. Known genetic ca ...
ChemInform Abstract: THE IODINATION OF AZETIDINONE THIO COMPOUNDS. UNSYM‐AZETIDINONE DISULFIDES FROM THIAZOLINOAZETIDINONES (1981)

Abstract Das Thiazolazetidinon (I) reagiert mit den Mercaptanen (II) und I2, d. h. mit in situ gebildeten Sulfenyliodiden, zu den Azetidinondisulfiden (III).
A Multi-State, Allosterically-Regulated Molecular Receptor With Switchable Selectivity (2014)

A biomimetic, ion-regulated molecular receptor was synthesized via the Weak-Link Approach (WLA). This structure features both a calix[4]arene moiety which serves as a molecular recognition unit and an activity regulator composed of hemilabile phosphine alkyl thioether ligands (P,S) chelated to a Pt(II) center. The host-guest properties of the ion-regulated receptor were found to be highly dependent upon the coordination of the Pt(II) center, which is controlled through the reversible coordination of small molecule effectors. The environment at the regulatory site dictates the charge and the structural conformation of the entire assembly resulting in three accessible binding configurations: one closed, inactive state and two open, active states. One of the active states, the semiopen state, recognizes a neutral guest molecule, while the other, the fully open state, recognizes a cationic guest molecule. Job plots and (1)H NMR spectroscopy titrations were used to study the formation of these inclusion complexes, the receptor binding modes, and the receptor binding affinities (Ka) in solution. Single crystal X-ray diffraction studies provided insight into the solid-state structures of the receptor when complexed with each guest molecule. The dipole moments and electrostatic potential maps of the structures were generated via DFT calculations at the B97D/LANL2DZ level of theory. Finally, we describe the reversible capture and release of guests by switching the receptor between the closed and semiopen configurations via elemental anion and small molecule effectors.