gebhart/patrepeval huggingface dataset:
RF gain instability in photonic links due to bias drift in Ti:LiNbO/sub 3/ Mach-Zehnder modulators (2003)

An optimal bias voltage, named the "stabilized quadrature bias voltage," has been identified for Mach-Zehnder modulators, which reduces RF gain instability. A practical remedy for RF gain instability is described.
Vaccination with chemically attenuated Plasmodium falciparum asexual blood-stage parasites induces parasite-specific cellular immune responses in malaria-naïve volunteers: a pilot study (2018)

Trial registration: ACTRN12614000228684 . Registered 4 March 2014.
C3d‐positive donor‐specific antibodies have a role in pretransplant risk stratification of cross‐match‐positive HLA‐incompatible renal transplantation: United Kingdom multicentre study (2020)

Anti-HLA-antibody characteristics aid to risk-stratify patients and improve long-term renal graft outcomes. Complement activation by donor-specific antibody (DSA) is an important characteristic that may determine renal allograft outcome. There is heterogeneity in graft outcomes within the moderate to high immunological risk cases (cross-match-positive). We explored the role of C3d-positive DSAs in sub-stratification of cross-match-positive cases and relate to the graft outcomes. We investigated 139 cross-match-positive living-donor renal transplant recipients from four transplant centres in the United Kingdom. C3d assay was performed on serum samples obtained at pretreatment (predesensitization) and Day 14 post-transplant. C3d-positive DSAs were found in 52 (37%) patients at pretreatment and in 37 (27%) patients at Day 14 post-transplant. Median follow-up of patients was 48 months (IQR 20.47-77.57). In the multivariable analysis, pretreatment C3d-positive DSA was independently associated with reduced overall graft survival, the hazard ratio of 3.29 (95% CI 1.37-7.86). The relative risk of death-censored five-year graft failure was 2.83 (95% CI 1.56-5.13). Patients with both pretreatment and Day 14 C3d-positive DSAs had the worst five-year graft survival at 45.5% compared with 87.2% in both pretreatment and Day 14 C3d-negative DSA patients with the relative risk of death-censored five-year graft failure was 4.26 (95% CI 1.79, 10.09). In this multicentre study, we have demonstrated for the first time the utility of C3d analysis as a distinctive biomarker to sub-stratify the risk of poor graft outcome in cross-match-positive living-donor renal transplantation.
Cytoplasmic p27Kip1 promotes tumorigenesis via suppression of RhoB activity (2018)

The cell cycle inhibitor p27<sup>Kip1</sup> is a tumor suppressor via the inhibition of CDK complexes in the nucleus. However, p27 also plays other functions in the cell and may acquire oncogenic roles when located in the cytoplasm. Activation of oncogenic pathways such as Ras or PI3K/AKT causes the relocalization of p27 in the cytoplasm, where it can promote tumorigenesis by unclear mechanisms. Here, we investigated how cytoplasmic p27 participates in the development of non-small cell lung carcinomas. We provide molecular and genetic evidence that the oncogenic role of p27 is mediated, at least in part, by binding to and inhibiting the GTPase RhoB, which normally acts as a tumor suppressor in the lung. Genetically modified mice revealed that RhoB expression is preferentially lost in tumors in which p27 is absent and maintained in tumors expressing wild-type p27 or p27<sup>CK-</sup> , a mutant that cannot inhibit CDKs. Moreover, although the absence of RhoB promoted tumorigenesis in p27<sup>-/-</sup> animals, it had no effect in p27<sup>CK-</sup> knock-in mice, suggesting that cytoplasmic p27 may act as an oncogene, at least in part, by inhibiting the activity of RhoB. Finally, in a cohort of lung cancer patients, we identified a subset of tumors harboring cytoplasmic p27 in which RhoB expression is maintained and these characteristics were strongly associated with decreased patient survival. Thus, monitoring p27 localization and RhoB levels in non-small cell lung carcinoma patients appears to be a powerful prognostic marker for these tumors. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
975. Totally synthetic steroid hormones. Part I. Oestrone and related œstrapolyenes (1963)

G. H. Douglas, J. M. H. Graves, D. Hartley, G. A. Hughes, B. J. McLoughlin, J. Siddall and H. Smith, J. Chem. Soc., 1963, 5072 DOI: 10.1039/JR9630005072
Percutaneous intratumoral injection of cisplatin microspheres in tumor-bearing rats to diminish acute nephrotoxicity (1996)

Anti-Cancer Drugs reports both clinical and experimental results related to anti-cancer drugs, and welcomes contributions on anti-cancer drug design, drug delivery, pharmacology, hormonal and biological modalities and chemotherapy evaluation. An internationally refereed journal devoted to the fast publication of innovative investigations on therapeutic agents against cancer, Anti-Cancer Drugs aims to stimulate and report research on both toxic and non-toxic anti-cancer agents. Consequently, the scope on the journal will cover both conventional cytotoxic chemotherapy and hormonal or biological response modalities such as interleukins and immunotherapy. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.
The scanning tunneling microscope as a high-gain, low-noise displacement sensor (1990)

We consider the capabilities of the tunneling probe of the scanning tunneling microscope as a displacement sensor as distinguished from its better established application to surface imaging. Electromechanical transducers that operate on this principle can achieve very large gain and a noise temperature equal to the minimum required by quantum mechanics for any linear amplifier. We present a two-port network representation of the tunneling transducer, including noise, that allows us to discuss the differences between the tunneling transducer and more conventional electromechanical transducers and to draw analogies between a tunneling transducer and a transistor. We present a simple equivalent circuit for the tunneling transducer including two uncorrelated noise generators, the tunneling current shot noise and the fluctuating force that the tunneling probe exerts on a test mass. In practice the fluctuating ‘‘back action’’ force spectral density is exceedingly small. We give an example of a system in which a tunneling transducer is used to monitor the motion of a very small mechanical harmonic oscillator. A transducer gain of approximately 108 should be achieved in this system that makes negligible the noise contribution of conventional following electronics. The contribution to the noise of the tunneling transducer itself should be near the quantum limit and the most significant remaining source of noise is the mechanical oscillator’s Brownian motion. The tunneling transducer represents a new approach for measuring mechanical displacements and may profoundly influence transducer technology in applications from gravity wave detectors down to measurements on single molecules.
Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries (2009)

The development of arteries, veins and lymphatics from pre-existing vessels are intimately linked processes controlled by a number of well-studied reiteratively acting signalling pathways. To delineate the mechanisms governing vessel formation in vivo, we performed a forward genetic screen in zebrafish and isolated the mutant expando. Molecular characterisation revealed a loss-of-function mutation in the highly conserved kinase insert region of flt4. Consistent with previous reports, flt4 mutants were deficient in lymphatic vascular development. Recent studies have demonstrated a role for Flt4 in blood vessels and showed that Dll4 limits angiogenic potential by limiting Flt4 function in developing blood vessels. We found that arterial angiogenesis proceeded normally, yet the dll4 loss-of-function arterial hyperbranching phenotype was rescued, in flt4 signalling mutants. Furthermore, we found that the Flt4 ligand Vegfc drives arterial hyperbranching in the absence of dll4. Upon knockdown of dll4, intersegmental arteries were sensitised to increased vegfc levels and the overexpression of dll4 inhibited Vegfc/Flt4-dependent angiogenesis events. Taken together, these data demonstrate that dll4 functions to suppress the ability of developing intersegmental arteries to respond to Vegfc-driven Flt4 signalling in zebrafish. We propose that this mechanism contributes to the differential response of developing arteries and veins to a constant source of Vegfc present in the embryo during angiogenesis.
Radiofrequency catheter ablation of left lateral accessory pathways via the coronary sinus. (1992)

Radiofrequency catheter ablation of left lateral APs can be achieved effectively and relatively safely via the mid or distal coronary sinus when endocardial approaches are unsuccessful.
Chronic effects of nitrendipine on renal hemodynamics and tubular transport (1988)

The effects of nitrendipine (10 mg, during acute clearance experiments) given both acutely and after 2 weeks of administration were examined in normal and hypertensive subjects. At the initiation of therapy, nitrendipine caused an increase in glomerular filtration rate and effective renal plasma flow in the hypertensive, but not in the normal, group. Percentage excretion rates of sodium (%ENa) and phosphate (%EPi) and free water clearance (CW) increased in both groups at the initiation of therapy. After 2 weeks of nitrendipine therapy repeat acute clearance studies showed that the drug no longer increased glomerular filtration rate or effective renal plasma flow in hypertensive subjects, the increases in %ENa and CW persisted in normal subjects and trended upward in hypertensive subjects, and the increase in %EPi persisted in both normal and hypertensive individuals. We conclude that nitrendipine is not sodium retentive after chronic therapy and the acute increase in %ENa, %EPi, and CW after its initial administration suggests a proximal tubular effect.
Pyrolysis Characteristics of Forest Residues Obtained from Different Harvesting Methods (2011)

Although forests promise an abundant supply for residue biomass for biorefining and biopower applications, heterogeneity generated in residue due to collection methods or selection process (limb, top, and understory etc.) may influence biofuel production in both the thermochemical and fermentation pathways. This article focuses on effects of collection methods on the fuel properties, thermochemical decomposition behavior, and properties of pyrolysis bio-oil and char. Forest residues studied in this research include: clean wood chips (CW), horizontal grinder material (GM), pre-commercially thinned biomass chips (PC-chips), biomass chips produced from pine limbs and tops (T-chips), and biomass chips produced from hardwood understory stems and pine limbs and tops (TU-chips). All biomass samples were characterized by measuring bulk density, moisture, chemical composition (cellulose, hemicellulose, lignin, ash, and extractives), energy density, proximate analysis (moisture, fixed carbon, volatile matter, and ash), and ultimate (C, H, N, S, O) analysis. Pyrolysis was performed on partially dried biomass samples to produce char and bio-oil. The yields of pyrolysis products were calculated. Char was characterized by proximate and ultimate analysis, energy density, and iodine number; and, bio-oil was characterized by pH, viscosity, ultimate analysis, energy density, and water content. In addition, fixed carbon yields, char carbon efficiency, and energy conversion efficiency of char were also calculated. Results showed that the GM had the highest ash content (5.9%) and the lowest energy density (17.03 MJ/kg) among all forest residues evaluated. TU-chips had higher concentration of extractives which resulted in an additional decomposition peak at 300C beyond the main peak which appeared at 370C responsible for decomposition of cellulose and hemicelluloses in thermogravimetric analysis. Results from this study showed no significant difference in char and bio-oil yields in the various forest residues evaluated; however, GM char which was large in ash content, because of contamination by soil inclusion had lower heating value and adsorption capacity. All residues evaluated produced bio-oil with similar fuel properties.
Long-haul 10 Gbit/s linear and non-linear IMDD transmission over uncompensated standard fiber using a SQRT-metric MLSE receiver (2008)

We experimentally demonstrated Intensity-Modulated Direct-Detection (IMDD) single-channel 1,040 km linear transmission and 800 km non-linear transmission at 10 Gb/s over standard single-mode (G.652) fiber, without any optical dispersion compensation or mitigation, using a Maximum-Likelihood Sequence-Estimation (MLSE) receiver employing the square-root (SQRT) branch metric with off-line processing. These experiments were designed as to probe the limits of the MLSE approach. They successfully showed that long-haul uncompensated transmission is in principle possible with MLSE, even in the presence of large uncompensated dispersion and strong intra-channel fiber non-linearities, provided that enough complexity can be built into the receiver. In the linear 1,040 km experiment, a Bit Error Rate (BER) of 10(-3) was achieved with an Optical Signal-to-Noise Ratio (OSNR) penalty with respect to back-to-back of 2.9 dB, using two samples per bit and 16,384 trellis states. Several other set-ups were tested as well, including the use of only one sample per bit and fewer trellis states. In the non-linear 800 km experiment, power was ramped up to 12 dBm, exciting substantial Kerr non-linearity, whose induced spectral-broadening exacerbated the effects of the large uncompensated dispersion of the link. Using an MLSE receiver with 1,024 states, we demonstrated a non-linear threshold of 9 dBm. We benchmarked this experiment towards simulations addressing various electrical and optical dispersion compensation strategies. We also carried out an analysis of error run-lengths, on both experiments, which showed that error burstiness may change considerably depending on the number of processor states, OSNR and the amount of non-linearity in the link.
Highly Regioselective Nickel-Catalyzed Cross-Coupling ofN-Tosylaziridines and Alkylzinc Reagents (2014)

Herein, we report the first ligand-controlled, nickel-catalyzed cross-coupling of aliphatic N-tosylaziridines with aliphatic organozinc reagents. The reaction protocol displays complete regioselectivity for reaction at the less hindered C-N bond, and the products are furnished in good to excellent yield for a broad selection of substrates. Moreover, we have developed an air-stable nickel(II) chloride/ligand precatalyst that can be handled and stored outside a glovebox. In addition to increasing the activity of this catalyst system, this also greatly improves the practicality of this reaction, as the use of the very air-sensitive Ni(cod)2 is avoided. Finally, mechanistic investigations, including deuterium-labeling studies, show that the reaction proceeds with overall inversion of configuration at the terminal position of the aziridine by way of aziridine ring opening by Ni (inversion), transmetalation (retention), and reductive elimination (retention).
A digitally stabilized type-III PLL using ring VCO with 1.01ps<inf>rms</inf> integrated jitter in 65nm CMOS (2012)

The design of low-jitter VCO-based PLLs is quite challenging as high VCO control gain, K <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">VCO</sub> , increases the phase noise contribution arising from the charge pump and loop filter. To resolve this problem, dual-tuning PLLs (DT-PLLs) have been studied [1-4]. The DT-PLL structure adds a narrow-bandwidth coarse (high-K <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">VCO</sub> ) path to the fine (low-K <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">VCO</sub> ) path consisting of a type-II PLL. The narrow-bandwidth analog filter in the coarse path plays an important role in preventing the charge pump and the loop filter from increasing the output jitter, while a wide-tuning range is maintained. Moreover, the coarse path adds another pole at origin to the fine path and transforms it from a type-II to type-III PLL [3-4]. Compared to a type-II PLL, owing to its boosted low-frequency loop gain, a type-III PLL can better suppress a low-frequency disturbance to the ring VCO, such as temperature drift. However, a type-III PLL has stability problems. To ensure sufficient phase margin (PM), a type-III PLL requires an extremely narrow-bandwidth (e.g. ~10-100Hz) analog filter in the coarse path or must make the K <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">VCO</sub> of the fine path larger. The former requires a nano-Farad capacitor or a fairly complex design for shrinking the capacitance, while the latter way increases total jitter. This paper presents a digitally stabilized type-Ill PLL with a ring VCO. It employs a DT-PLL structure and improves its stability by composing the coarse path with a digital integrator and a digital-to-analog converter (DAC). It can set the K <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">vco</sub> of the fine path to 10MHz/V, which is 1000χ lower than that of the coarse path with a sufficient PM. For further in-band phase-noise reduction, the proposed type-Ill PLL adopts a sub-sampling PLL (SS-PLL) in its fine path [5], and achieves 1.01 ps <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> integrated jitter.
Piecewise flat embeddings for hyperspectral image analysis (2017)

Graph-based dimensionality reduction techniques such as Laplacian Eigenmaps (LE), Local Linear Embedding (LLE), Isometric Feature Mapping (ISOMAP), and Kernel Principal Components Analysis (KPCA) have been used in a variety of hyperspectral image analysis applications for generating smooth data embeddings. Recently, Piecewise Flat Embeddings (PFE) were introduced in the computer vision community as a technique for generating piecewise constant embeddings that make data clustering / image segmentation a straightforward process. In this paper, we show how PFE arises by modifying LE, yielding a constrained ℓ<sup>1</sup>-minimization problem that can be solved iteratively. Using publicly available data, we carry out experiments to illustrate the implications of applying PFE to pixel-based hyperspectral image clustering and classification.
Correction to “Unraveling 1-Hexene Hydrogenation over Dilute Pd-in-Au Alloys” (2023)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Unraveling 1-Hexene Hydrogenation over Dilute Pd-in-Au Alloys"Jessi E. S. van der Hoeven*Jessi E. S. van der Hoeven*Email: [email protected]More by Jessi E. S. van der Hoeven, Hio Tong NganHio Tong NganMore by Hio Tong Ngan, George YanGeorge YanMore by George Yan, Joanna AizenbergJoanna AizenbergMore by Joanna Aizenberghttps://orcid.org/0000-0002-2343-8705, Robert J. MadixRobert J. MadixMore by Robert J. Madixhttps://orcid.org/0000-0002-3132-2382, Philippe SautetPhilippe SautetMore by Philippe Sautethttps://orcid.org/0000-0002-8444-3348, and Cynthia M. Friend*Cynthia M. Friend*Email: [email protected]More by Cynthia M. Friendhttps://orcid.org/0000-0002-8673-9046Cite this: J. Phys. Chem. C 2023, 127, 11, 5640–5641Publication Date (Web):March 10, 2023Publication History Received25 January 2023Published online10 March 2023Published inissue 23 March 2023https://pubs.acs.org/doi/10.1021/acs.jpcc.3c00557https://doi.org/10.1021/acs.jpcc.3c00557correctionACS PublicationsCopyright © 2023 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views306Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (1 MB) Get e-Alertsclose Get e-Alerts
Effect of Orthostatic Hypotension on Kidney Function (2023)

Classic OH can negatively affect long-term kidney function in the general population.
A Mammalian Cell-Based Assay for Screening Inhibitors of RNA Cleavage (2009)

RNA cleavage is a catalytic reaction which defines many types of RNA processing events, including those of metabolite-sensing riboswitch, self-splicing introns, mRNA splicing, tRNA processing, polyA-cleavage, and various small ribozymes such as hairpin and hammerhead ribozyme. In this chapter, we describe a general methodology for developing a mammalian cell-based high-throughput screening assay useful for identifying small molecules capable of inhibiting RNA cleavage in mammalian cells. In the specific assay described, a plasmid DNA vector in which the expression of a luciferase reporter gene is controlled by hammerhead ribozyme cleavage was stably introduced into the human 293 cell line. Such a cell line enabled the rapid screening of chemical compound libraries and the identification of cell membrane-permeable inhibitory molecules capable of blocking ribozyme cleavage. The general strategy described later could in principle be adapted to identify small molecule inhibitors of many types of RNA cleavage reactions.
Calibrating Virtual Environments for Engineering Applications (2001)

Abstract A major disadvantage of some tracking systems used in virtual reality environments is the degradation in accuracy due to the presence of metals and other electromagnetic distortions in the environment. Calibration of the virtual environment to account for these distortions is essential for VR applications in engineering where correlation between the virtual environment and the physical world is important. The goal of the calibration process is to map the distorted tracker space to the physical space as accurately as possible for real-time applications. In this paper the authors present an integrated calibration system used with an electromagnetic tracking system. The components of this system are described in detail, including data collection, grid refinement, interpolation, and evaluation. The paper describes different alternatives for measuring systematic errors of magnetic trackers in a room, and for automatically correcting them using various techniques to interpolate between sets of measurements to achieve error estimates and corrections. Several key techniques and algorithms are presented in detail and evaluated in terms of accuracy and execution time over a range of cell densities. Among the interpolation methods considered are inverse distance weighting and affine transformation mappings, as well as variations and combinations of these. The calibration system, called COVE (Calibration of Virtual Environments), has been successful in allowing accurate tracking for several engineering applications.