gebhart/patrepeval huggingface dataset:
Figure-of-eight Brillouin/erbium fibre lasers (1998)

Multiple wavelength lasing in an all-fibre figure-of-eight Brillouin/erbium fibre laser is presented. The simultaneous presence of a stimulated Brillouin scattering (SBS) pump and generated Stokes lines within a Sagnac loop mirror (SLM) initiated high order Stokes and anti-Stokes waves through the four-wave mixing (FWM) process.
Structural Analysis of Siah1 and Its Interactions with Siah-interacting Protein (SIP) (2003)

Seven in absentia homologue (Siah) family proteins bind ubiquitin-conjugating enzymes and target proteins for proteasome-mediated degradation. Recently we identified a novel Siah-interacting protein (SIP) that is a Sgt1-related molecule that provides a physical link between Siah family proteins and the Skp1-Cullin-F-box ubiquitin ligase component Skp1. In the present study, a structure-based approach was used to identify interacting residues in Siah that are required for association with SIP. In Siah1 a large concave surface is formed across the dimer interface. Analysis of the electrostatic surface potential of the Siah1 dimer reveals that the beta-sheet concavity is predominately electronegative, suggesting that the protein-protein interactions between Siah1 and SIP are mediated by ionic contacts. The structural prediction was confirmed by site-directed mutagenesis of these electronegative residues, resulting in loss of binding of Siah1 to SIP in vitro and in cells. The results also provide a structural basis for understanding the mechanism by which Siah family proteins interact with partner proteins such as SIP.
Experimental Evaluation of Machine Learning Methods for Robust Received Signal Strength-Based Visible Light Positioning (2020)

In this work, the use of Machine Learning methods for robust Received Signal Strength (RSS)-based Visible Light Positioning (VLP) is experimentally evaluated. The performance of Multilayer Perceptron (MLP) models and Gaussian processes (GP) is investigated when using relative RSS input features. The experimental set-up for the RSS-based VLP technology uses light-emitting diodes (LEDs) transmitting intensity modulated light and a single photodiode (PD) as a receiver. The experiments focus on achieving robustness to cope with unknown received signal strength modifications over time. Therefore, several datasets were collected, where per dataset either the LEDs transmitting power is modified or the PD aperture is partly obfuscated by dust particles. Two relative RSS schemes are investigated. The first scheme uses the maximum received light intensity to normalize the received RSS vector, while the second approach obtains RSS ratios by combining all possible unique pairs of received intensities. The Machine Learning (ML) methods are compared to a relative multilateration implementation. It is demonstrated that the adopted MLP and GP models exhibit superior performance and higher robustness when compared to the multilateration strategies. Furthermore, when comparing the investigated ML models, the GP model is proven to be more robust than the MLP for the considered scenarios.
Characterisation of MC Fibers: New Techniques and Challenges (2012)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text K. Takenaga, S. Matsuo, K. Saitoh, and M. Koshiba, "Characterisation of MC Fibers: New Techniques and Challenges," in Optical Fiber Communication Conference, OSA Technical Digest (Optica Publishing Group, 2012), paper OTu1D.5. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
A Graphene "MnO2" Hybrid Supercapacitor Based on In Situ Electo-Deposition and Dissolution of "MnO2" (2011)

The principle of feasibility of a hybrid super-capacitor, based on graphene and the electrochemical deposition and dissolution of "MnO2", is demonstrated. For this system, a composite graphene electrode is used as the capacitive electrode. Graphene is also used in the battery type electrode, where it serves as substrate for the in-situ electrochemical deposition and dissolution of "MnO2". The electrochemical deposition and dissolution reaction provides the bulk of the charge storable in the battery type electrode. The characteristics of the two electrodes are discussed showing that their respective potential windows of stabilities are compatible with the aqueous the electrolyte. Subsequently, two hybrid systems are assembled and subjected to long charge/discharge cycles. One assembly displays an energy density of 34 and 25 Wh kg-1 after the first and 5000th cycle, respectively.
Biosynthesized Multivalent Lacritin Peptides Stimulate Exosome Production in Human Corneal Epithelium (2020)

Lacripep is a therapeutic peptide derived from the human tear protein, Lacritin. Lacripep interacts with syndecan-1 and induces mitogenesis upon the removal of heparan sulfates (HS) that are attached at the extracellular domain of syndecan-1. The presence of HS is a prerequisite for the syndecan-1 clustering that stimulates exosome biogenesis and release. Therefore, syndecan-1-mediated mitogenesis versus HS-mediated exosome biogenesis are assumed to be mutually exclusive. This study introduces a biosynthesized fusion between Lacripep and an elastin-like polypeptide named LP-A96, and evaluates its activity on cell motility enhancement versus exosome biogenesis. LP-A96 activates both downstream pathways in a dose-dependent manner. HCE-T cells at high confluence treated with 1 μM LP-A96 enhanced cell motility equipotent to Lacripep. However, cells at low density treated with 1 μM LP-A96 generated a 210-fold higher number of exosomes compared to those treated at low density with Lacripep. As monovalent Lacripep is capable of enhancing cell motility but not exosome biogenesis, activation of exosome biogenesis by LP-A96 not only suggests its utility as a novel molecular tool to study the Lacritin biology in the corneal epithelium but also implies activity as a potential therapeutic peptide that can further improve ocular surface health through the induction of exosomes.
Identification and characterization of a bacterial glutamic peptidase (2010)

Based on the obtained results, we suggest that pepG1 can be added to the MEROPS family G1 as the first characterized bacterial member.
Modeling, Sensitivity Analysis, and Controller Synthesis of Multipickup Bidirectional Inductive Power Transfer Systems (2014)

Inductive power transfer (IPT) systems are increasingly being used in numerous industrial applications, which essentially require power without any physical contacts. In contrast to unidirectional IPT systems, bidirectional IPT systems are inherently higher-order resonant networks and relatively complex in modeling, design, and control. The complexity further exacerbates with the increase in number of pickups or loads, making design and implementation of such systems a real challenge. This paper, therefore, develops a multivariable dynamic model for a multipickup bidirectional IPT system, which can provide an accurate insight into the behavior of this system and can be used for controller synthesis under variations of component values. The output sensitivity to various parameters and the interaction among various control variables and degree of controllability of the system are investigated using frequency domain analysis. The validity of the model is verified under various operating conditions by comparing the predicted behavior with a 1-kW prototype of a bidirectional IPT system with two pickups. Measured results convincingly demonstrate that the proposed model accurately predicts the dynamic behavior of bidirectional IPT systems with multiple pickups and can, therefore, be used as a valuable tool for both dynamic analysis and controller design.
A Chiral Pool Based Synthesis of Platensimycin (2008)

Extensive pharming: An expedient entry into the tetracycle 2, a late-stage synthetic intermediate en route to the broad-spectrum antibiotic (−)-platensimycin (1) has been accomplished. The strategy involves a series of cyclizations starting from the inexpensive chiral pool starting material (R)-(−)-carvone. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z705080_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Assessment of advanced hepatic MR elastography methods for susceptibility artifact suppression in clinical patients (2017)

3 Technical Efficacy: Stage 5 J. Magn. Reson. Imaging 2018;47:976-987.
Model studies towards the synthesis of gilvocarcin M (2005)

In model studies towards the synthesis of gilvocarcin M, a convergent, xanthate-based free-radical strategy was tested in order to construct the key aromatic ring attached to the sugar unit.
Structure–Property Relationships of Pure Cellulose and GO/CEL Membranes Regenerated from Ionic Liquid Solutions (2019)

Two types of cellulose membranes were produced by a classical wet phase inversion method from a solution of the polymer in 1-ethyl-3-methylimidazolium acetate (EMIMAc) by coagulation in water and selected primary alcohols. The first type were membranes made from pure cellulose (CEL). The second type were membranes obtained by adding nanosized graphene oxide (GO) to the cellulose solution. The process of precipitation and selection of the coagulant affected the structure of the membranes, which in turn affected their usability and applicability. The results of the presented studies show that the physicochemical properties of the coagulant used (e.g., molecular mass and dipole moment) play important roles in this process. It was found that both the content and dimensions of the pores depended on the molecular mass of the coagulant used. It was also found that the dipole moment of coagulant molecules had a large influence on the volume content of the pores (e.g., the 1-octanol (Oc) membrane had a dipole moment of 1.71 D; <i>Φ</i> = 1.82%). We investigated the effect of the type of coagulant on the porous structure of CEL membranes and how this affected the transport properties of the membranes (e.g., for the distilled water (W) membrane, <i>J<sub>v</sub></i> = 5.24 ± 0.39 L/m<sup>2</sup> h; for the Oc membrane, <i>J<sub>v</sub></i> = 92.19 ± 1.51 L/m<sup>2</sup> h). The paper presents the results of adding GO nanoparticles in terms of the structure, morphology, and transport properties of GO/CEL membranes (e.g., for composite membrane F (containing 20% GO), <i>J</i><sub>v</sub> = 40.20 ± 2.33 L/m<sup>2</sup> h). In particular, it describes their extremely high ability to remove heavy metal ions.
Disconnection protocol support in mobile access (1999)

Mobile access remains limited by relatively short battery power lifetime, expensive wireless bandwidth and areas with difficult or no continuous communication coverage. It is believed that as many as 70% of laptop users would operate in planned or non planned disconnected mode. Although existing approaches have led to implementing disconnected mode operation within applications, we chose to introduce changes to a mobile extension of the Internet transport protocol. We show through simulation that this protocol performs better than TCP. In order to evaluate disconnection parameters including disconnection and inter-disconnection times, a performance study of disconnection is presented. Finally we argue that disconnection is an important service and should therefore be considered as a Quality of Service (QoS) parameter to be negotiated among mobile and fixed communication entities.
Assembly Process Development of Ultra Large Scale 3D Stacking with Transmission Circuits Via TSVs (2018)

This paper introduces the assembly process development of ultra large scale 3D stacking, using both CFD and thermo-mechanical simulations. The height of C4 bumps in 3D stacking was optimized for satisfactory flux cleaning performance and fatigue lifetime estimates by controlling the minimum height and adding the necessary volume of solder to each C4 bump. With the procedure developed for stacking, a prototype processor was successfully mounted on a substrate and then assembled on a printed wiring board. To validate interconnections from the top chip to the printed wiring board, a test pattern program was run and signal transmission in multiple lanes, where the top and bottom chips communicated with each other through TSVs and micro bumps, was confirmed at speeds of over 1 GHz; in addition, the connectivity was confirmed with daisy chain interconnections.
Photochemistry of Conj ugated Polyacetylenes. Photoreaction of 1,4-Diphenyl-1,3-butadiyne with Unsymmetrical Olefins (1991)

Abstract Irradiation of 1,4-diphenyl-1,3-butadiyne (DPB) with unsymmetrical olefins such as acrylonitrile and ethyl vinyl ether yields regiospecific 1:1 and 1:2 photoadducts. The reactive site on the formation of 1:2 photoadducts is different from each other indicating that the reaction proceeds through polar excited states.
Direct Regiospecific and Highly Enantioselective Intermolecular α‐Allylic Alkylation of Aldehydes by a Combination of Transition‐Metal and Chiral Amine Catalysts (2012)

The first direct intermolecular regiospecific and highly enantioselective α-allylic alkylation of linear aldehydes by a combination of achiral bench-stable Pd(0) complexes and simple chiral amines as co-catalysts is disclosed. The co-catalytic asymmetric chemoselective and regiospecific α-allylic alkylation reaction is linked in tandem with in situ reduction to give the corresponding 2-alkyl alcohols with high enantiomeric ratios (up to 98:2 e.r.; e.r.=enantiomeric ratio). It is also an expeditious entry to valuable 2-alkyl substituted hemiacetals, 2-alkyl-butane-1,4-diols, and amines. The concise co-catalytic asymmetric total syntheses of biologically active natural products (e.g., Arundic acid) are disclosed.
Facile Solid-Phase Synthesis and Assessment of Nucleoside Analogs as Inhibitors of Bacterial UDP-Sugar Processing Enzymes (2018)

The privileged uptake of nucleosides into cells has generated interest in the development of nucleoside-analog libraries for mining new inhibitors. Of particular interest are applications in the discovery of substrate mimetic inhibitors for the growing number of identified glycan-processing enzymes in bacterial pathogens. However, the high polarity and the need for appropriate protecting group strategies for nucleosides challenges the development of synthetic approaches. Here, we report an accessible, user-friendly synthesis that branches from a common solid phase-immobilized uridinyl-amine intermediate, which can be used as a starting point for diversity-oriented synthesis. We demonstrate the generation of five series of uridinyl nucleoside analogs for investigating inhibitor structure-activity relationships. This library was screened for inhibition of representative enzymes from three functional families including a phosphoglycosyl transferase, a UDP-aminosugar acetyltransferase, and a glycosyltransferase. These candidates were taken from the Gram-negative bacteria Campylobacter concisus and Campylobacter jejuni and the Gram-positive bacterium Clostridium difficile, respectively. Inhibition studies show that specific compound series preferentially inhibit selected enzymes, with IC<sub>50</sub> values ranging from 35 ± 7 μM to 174 ± 21 μM. Insights from the screen provide a strong foundation for further structural elaboration, to improve potency, which will be enabled by the same synthetic strategy. The solid-phase strategy was also used to synthesize pseudouridine analogs of lead compounds. Finally, the compounds were found to be nontoxic to mammalian cells, further supporting the opportunities for future development.
Fracture and Sub-Critical Crack Growth Behavior of Micromachined Single Crystal Silicon Structures (1998)

Abstract Currently little data exists on the fracture and subcritical crack growth behavior of single crystal silicon, a common material for micromachined devices. In order to obtain stable crack growth in silicon, we utilize a decreasing stress intensity specimen geometry (Gonzales and Pantano, 1990). We present new data on crack growth rates in silicon as a function of applied stress intensity (K). We made direct measurements of these values via optical and electrical resistance techniques under monotonic loading conditions. We also present new data on the critical stress intensity (KIc) of silicon for a sample of micromachined proportions.
MCP-1/CCR2-dependent loop for fibrogenesis in human peripheral CD14-positive monocytes (2006)

Monocyte/macrophage (Momicron) migration to sites of inflammation is a prerequisite cause of organ fibrosis. The recruitment and activation of Mo are regulated by C-C chemokines, especially monocyte chemoattractant protein-1 [(MCP-1)/CC chemokine ligand 2], which interacts with CC chemokine receptor 2 (CCR2). However, the mechanisms leading to fibrosis via MCP-1/CCR2 signaling in Mo remain to be investigated. The effect of MCP-1 on the expression of MCP-1, CCR2, transforming growth factor-beta1 (TGF-beta1), and type I collagen in circulating human CD14-positive Mo was investigated. In addition, the impact of MCP-1-specific or TGF-beta1-specific antisense (AS) phosphorothioate oligodeoxynucleotides (ODN) was examined to explore the involvement of autocrine/paracrine production of MCP-1 and TGF-beta1 by human CD14-positive Mo. Furthermore, specific CCR2 inhibitors were applied to examine the involvement of CCR2 signaling for the promotion of a fibrogenic response. The stimulation of Mo with MCP-1 increased mRNA levels of TGF-beta1 and a pro-alpha1 chain of type I collagen (COL1A1) as well as protein synthesis. Similarly, the expression of MCP-1 and CCR2 was enhanced by the stimulation with MCP-1 in dose- and time-dependent manners. This positive loop via MCP-1 was reduced by pretreatment with MCP-1-specific AS-ODN. It was also noted that pretreatment with TGF-beta1-specific AS-ODN partially reduced COL1A1 mRNA levels. Finally, transcripts of these molecules were suppressed by pretreatment with specific CCR2 inhibitors. The present study demonstrated that human peripheral CD14-positive Mo contribute directly to fibrogenesis by a MCP-1/CCR2-dependent amplification loop. These data suggest that fibrogenic processes in Mo regulated by MCP-1/CCR2 may be novel, therapeutic targets for combating organ fibrosis.
Three-Hindered Quadrant Phosphine Ligands with an Aromatic Ring Backbone for the Rhodium-Catalyzed Asymmetric Hydrogenation of Functionalized Alkenes (2012)

The three-hindered quadrant phosphine ligands (R)-1-tert-butylmethylphosphino-2-(di-tert-butylphosphino)benzene ((R)-3H-BenzP*) and (R)-2-tert-butylmethylphosphino-3-(di-tert-butylphosphino)quinoxaline ((R)-3H-QuinoxP*) exhibited good to excellent enantioselectivities in the rhodium-catalyzed asymmetric hydrogenation of selected dehydroamino acid derivatives, enamides, and ethenephosphonates.
Analysis on a generalized algorithm for the strong discrete logarithm problem with auxiliary inputs (2014)

We investigate a recently proposed algorithm solving the strong discrete logarithm problem with auxiliary inputs, and show that this algorithm in general is not more efficient than ordinary discrete-logarithm-solving algorithms such as Pollard’s rho method, by analyzing a lower bound on the sum of digits of integers.
Optimisation of adenovirus-based vectors as oral vacines (2008)

International audience
Peer-Assisted Timely Report Delivery in Social Swarming Applications (2014)

In social swarming applications, participants equipped with 3G and WiFi-capable smartphones are tasked to provide reports (possibly voluminous ones that include full-motion video) about their immediate environment to a central coordinator. In this paper, we consider the problem of timely delivery of these reports: Each report has an associated deadline, and the goal of the system is to retrieve as many reports as possible (or retrieve the most valuable reports), while satisfying each report's deadline. Reporters can use their cellular interface to upload their reports but can also ask neighbors (using their faster WiFi interface) to help upload parts of their reports. Under an assumption that WiFi transmission delays are negligible, we first show that there exists a polynomial time optimal solution using an earliest-deadline-first (EDF) strategy for achieving the goals described above. In practice, WiFi delays are not negligible; in this case, it turns out that the scheduling problem is strongly NP-hard. We formulate two heuristic algorithms, and show, through simulations and experiments on an Android-based implementation, that these heuristics perform 2-4× better than without peer-assistance, and within 60% of an upper-bound on the optimal.
Efficacy of Nivolumab and AVD in Early-Stage Unfavorable Classic Hodgkin Lymphoma (2020)

ClinicalTrials.gov Identifier: NCT03004833.
Wetting of Ga droplets in SiO$_2$/Si cavities: Application to self-assisted GaAs nanowire growth (2022)

In this paper we compute and compare the surface energy of various Ga liquid droplets wetting a cylindrical cavity in various configurations. While for some of these configurations the surface energy can be computed explicitely for others numerical computation is needed. Motivated by the results obtained for the cylindrical cavities we explore the case of the more realistic situation, conical cavities. Our results provide a relation between the geometry of the conical cavity and the equilibirum wetting angles of the droplet on the bottom and on the sidewall of the cavity which insure the dewetting of the lateral surface. This is an important result toward the control of the verticality during the nanowire growth by the vapor liquid solid method.
Energy-Efficient Bandwidth Allocation for Multi-User Video Streaming Over Wlan (2007)

We consider the problem of packet scheduling for the transmission of multiple video streams over a wireless local area network (WLAN). A cross-layer optimization framework is proposed to minimize the wireless transceiver energy consumption while reaching the user required visual quality. The framework relies on the IEEE 802.11 standard and on a wavelet-based scalable video coding scheme. It extends our previous work on energy-efficient scheduling by introducing an application-level video quality metric as QoS constraint (instead of a quality metric at the level of the communication layers) and by reformulating the energy minimization problem subject to the QoS constraint in order to also consider the fairness among users. Simulation results demonstrate significant additional energy gains by means of these extensions.