gebhart/patrepeval huggingface dataset:
Long Term Responses to Fludarabine and Rituximab in Waldenstrom’s Macroglobulinemia (2008)

Abstract Fludarabine and rituximab are commonly used in combination in the treatment of Waldenstrom’s macroglobulinemia (WM), though long term outcome of this regimen remains to be defined. We therefore examined the outcome of 43 WM patients treated on a clinical trial whose eligibility included &amp;lt; 2 prior therapies, and no previous nucleoside analogue or rituximab treatment. Therapy consisted of 6 cycles (25 mg/m2/day for 5 days) of fludarabine and 8 infusions (375 mg/m2/week) of rituximab over 31 weeks. 43 patients were enrolled with a median age of 61, and median prior therapies of 0. Responses were: CR (n=2); VGPR (n=14); PR (n=21); MR (n=4); for an overall and major response rate of 95.3% and 86.0%, respectively. At best response, median bone marrow disease involvement declined from 55% to 5% (p&amp;lt;0.00001), while serum IgM decreased from 3,840 to 443 mg/dL (p&amp;lt;0.00001), and hematocrit rose from 31.2% to 38.0% (p&amp;lt;0.0008). The median time to progression for all patients was 51.2 months, and was longer for untreated versus previously treated patients (77.6 vs. 38.4 months; p=0.017), as well as for those patients who achieved ≥ VGPR versus &amp;lt;VGPR (&amp;gt;88.3 vs. 36.9 months; p=0.049). Grade ≥ 3 toxicities included neutropenia (n=27); thrombocytopenia (n=7); pneumonia (n=6), including two patients who succumbed to non-PCP interstitial pneumonia; peripheral neuropathy (n=2); limbic encephalitis (n=1); hemolytic anemia (n=1). With a median follow-up of 40.3 months, we observed transformation to aggressive lymphoma (n=3); myelodysplasia (n=1); acute myelogenous leukemia (n=2); bladder carcinoma (n=1); and carcinoma of unknown primary (n=1) among 8 patients. The results of this study demonstrate that fludarabine and rituximab is an active regimen in WM, though short and long term toxicities need to be carefully weighed against other available treatment options.
Application of analysis of algorithms in cryptography (2004)

The thesis integrates several results that bring together analysis of algorithms and cryptography. The first chapter covers two results about domain extenders for hash functions. It introduces is a continuum of function classes bridging universal one-way hash functions and collision-resistant hash functions. From the complexity-theoretic point of view, the continuum is divided into two classes of equivalence, only one of which admits the Merkle-Damgaard construction for domain extension. Secondly, we prove a lower bound via a combinatorial argument on the key length of the Shoup construction (applicable to the other class) in some natural model. 
The next chapter analyzes a popular stream cipher, modeling it as a random walk on the symmetric group. The internal state of RC4 is a secret permutation that is shuffled during the key initialization step and by the pseudo-random number generator during the execution of the cipher. We observe that the mixing rate of the shuffling is important for security of the cipher. In particular, since the first byte of RC4 is output before the internal state is fully mixed, there is a detectable bias in the first byte. We bound the mixing rate of the shuffle and some experimental evidence that corroborates the conjecture that the upper bound is asymptotically tight. 
The last chapter of the thesis presents an average-case analysis of an important scheme for broadcast encryption for stateless receivers with user revocation. Additionally, we present an algorithm for computing optimal parameters of the extension of that scheme.
Block and Random Copolymers of 1,2-Cyclohexyl Cyclocarbonate and l-Lactide or Trimethylene Carbonate Synthesized by Ring-Opening Polymerization (2015)

The sequential and random ring-opening polymerizations (ROP) of racemic-trans-cyclohexene carbonate (rac-CHC) or enantiopure trans-(R,R)-cyclohexene carbonate ((R,R)-CHC) with l-lactide (LLA) or trimethylene carbonate (TMC) have been performed. Catalytic systems based on zinc diaminophenolate [(NNO)ZnEt] ((NNO)− = 2,4-di-tert-butyl-6-{[(2′-dimethylaminoethyl)methylamino]methyl}phenolate)) or tris[N,N-bis(trimethysilyl)amide]yttrium (Y[N(SiMe3)2]3) complexes, or a guanidine-type organocatalyst (1,5,7-triazabicyclo[4.4.0]dec-5-ene, TBD), combined to an alcohol (BnOH or iPrOH) as initiator/chain-transfer agent were used. Well-defined diblock P(rac-CHC)-b-PLLA and P((R,R)-CHC)-b-PLLA and random P(rac-CHC)-co-PLLA and P(rac-CHC)-co-PTMC copolymers were thus synthesized with molar mass values up to Mn,NMR = ca. 34 000 g mol–1 and rather narrow dispersity values (ĐM = 1.2–1.7). 1H and 13C{1H} NMR characterizations of the copolymers revealed the presence of −OBn or −OiPr chain-end groups, thereby supporting the active role of exogenous alcohol as initiator. No decarboxylation reaction was ever observed during any copolymerization, thus providing PCHC/PLLA and PCHC/PTMC copolymers void of ether defects. Thermal analysis of the copolymers assessed by DSC and TGA confirmed their block or random structure. The block PCHC-b-PLA and the random PCHC-co-PLLA and PCHC-co-PTMC copolymers represent the first examples of such copolymers synthesized by ring-opening copolymerization of the two comonomers. The latter PCHC-co-PTMC copolymers randomly combining CHC and TMC units are the first examples ever reported.
Minimal Incision Total Knee Arthroplasty Using the Suspended Leg Technique (2003)

This article describes an approach to minimize the soft-tissue trauma associated with total knee arthroplasty. A suspended leg technique provides full access to the knee by using flexion and the weight of the limb to stretch the incision. Violation of the extensor mechanism is minimized and soft-tissue balancing is enhanced with the suspended technique.
Limiting dilution comparison of the repertoires of high and low responder MHC-restricted T cells. (1988)

To approach the mechanism that determines Ir gene-controlled high or low responsiveness to whole proteins, such as sperm whale myoglobin (SWMb), we compared the repertoires of high and low responder haplotype-restricted T cells for different myoglobin epitopes by limiting dilution frequency analysis. Poisson analysis was performed using long-term limiting dilution cell lines of (B10.BR [low] X B10.D2[high])F1 T cells maintained on high or low responder APCs. The cell lines were tested with SWMb peptides and fragments for T cell repertoire fine specificities and Ia restrictions. The frequency of SWMb-specific F1 T cells responsive on B10.BR (H-2k) APCs was 2.5-3.6-fold lower than on B10.D2 (H-2d) APCs. Strikingly, all of the H-2k-restricted T cells used I-Ek as a restriction element, whereas both I-Ad- and I-Ed-restricted T cells were found among the H-2d-restricted lines. The I-Ad-restricted T cells were dominant, and the majority was specific for the synthetic peptide 102-118. T cells specific for peptide 132-146, dominant in association with I-Ed, were less frequent. However, no detectable H-2k-restricted T cells were specific for either of these peptides, but instead they were specific for fragment 1-55 or peptide 59-80. Fragment 1-55 also stimulated a similar number of H-2d-restricted T cells. Therefore, the low response of F1 T cells on H-2k-presenting cells may be due to the failure to see myoglobin plus I-Ak, in particular the immunodominant site around Glu 109, in contrast to the dominant response of high responder mice (both H-2d and H-2s) focused on the I-A molecule and the site around residue Glu 109. The I-E- low responder B10 strain also failed to respond to peptide 102-118, supporting the idea that the low responder status results from a limited repertoire lacking response to 102-118 plus I-A. In those strains that respond to the immunodominant site 102-118, the frequency of T cells in the repertoire specific for this site was always considerably greater than that for other sites. These results suggest that there is an important difference between immunodominant epitopes and minor epitopes and that Ir gene-controlled low responsiveness to a natural whole protein may be due primarily to the failure to respond to a single immunodominant site, even though a number of other epitopes can be recognized.
Reconfigurable Networking Hardware: A Classroom Tool (2006)

We present an educational platform for teaching the design, debugging and deployment of real networking equipment in the operational Internet. The emphasis of our work is on teaching and, therefore, on providing an environment that is flexible, robust, low cost and easy to use. The platform is built around 'NetFPGAs'-custom boards containing eight Ethernet ports and two FPGAs. NetFPGA boards, when used with VNS (Virtual Network System-another tool we have developed), can be integrated into dynamically configurable network topologies reachable from the Internet. VNS enables a user-space process running on any remote computer to function as a system controller for the NetFPGA boards. NetFPGA and VNS are used at Stanford in a graduate level networking course to teach router implementation in hardware and software.
Alignment and stacking of semiconductor photonic bandgaps by wafer-fusion (1999)

Semiconductor-based three-dimensional (3D) photonic crystals are developed by utilizing a wafer fusion and alignment technique. A clear and considerable bandgap effect is successfully demonstrated in infrared to near-infrared wavelengths. It is pointed out that the introduction of arbitrary defect states and/or efficient light emitters can be possible in this method. For the example of the introduction of a light-emitting element, a surface-emitting laser with a two-dimensional (2D) photonic crystal structure is fabricated, and very unique lasing characteristics are demonstrated. These results encourage us very much for the development of various quantum optical devices and circuits including not only passive, but also active devices.
Divanadium, .delta. .fwdarw. .delta.* transition: experiment and X.alpha. theory (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDivanadium, .delta. .fwdarw. .delta.* transition: experiment and X.alpha. theoryMark P. Andrews and Geoffrey A. OzinCite this: J. Phys. Chem. 1986, 90, 13, 2852–2859Publication Date (Print):June 1, 1986Publication History Published online1 May 2002Published inissue 1 June 1986https://pubs.acs.org/doi/10.1021/j100404a016https://doi.org/10.1021/j100404a016research-articleACS PublicationsRequest reuse permissionsArticle Views52Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Pyridyl Pyrrolide Boron Complexes: The Facile Generation of Thermally Activated Delayed Fluorescence and Preparation of Organic Light‐Emitting Diodes (2016)

Abstract The electron positive boron atom usually does not contribute to the frontier orbitals for several lower‐lying electronic transitions, and thus is ideal to serve as a hub for the spiro linker of light‐emitting molecules, such that the electron donor (HOMO) and acceptor (LUMO) moieties can be spatially separated with orthogonal orientation. On this basis, we prepared a series of novel boron complexes bearing electron deficient pyridyl pyrrolide and electron donating phenylcarbazolyl fragments or triphenylamine. The new boron complexes show strong solvent‐polarity dependent charge‐transfer emission accompanied by a small, non‐negligible normal emission. The slim orbital overlap between HOMO and LUMO and hence the lack of electron correlation lead to a significant reduction of the energy gap between the lowest lying singlet and triplet excited states (Δ E T‐S ) and thereby the generation of thermally activated delay fluorescence (TADF).
Delay efficient cooperation in public safety vehicular networks using LTE and IEEE 802.11p (2012)

Cooperative schemes for critical content distribution over vehicular networks are presented and analyzed. The first scheme is based on unicasting from the base station, whereas the second is based on threshold based multicasting. Long Term Evolution (LTE) is used for long range communications with the base station (BS) and 802.11p is considered for inter-vehicle collaboration on the short range. A high mobility environment with correlated shadowing is adopted. Both schemes are shown to outperform non-cooperative unicasting and multicasting, respectively, when the appropriate 802.11p power class is used. The first scheme achieves the best performance among the compared methods, and a practical approximation of that scheme is shown to be close to optimal performance. © 2012 IEEE.
Properties and morphology of doped polycrystalline. beta. double prime -alumina electrolytes (1989)

{beta}{double prime}-alumina specimens were fabricated from commercial {beta}{double prime}-alumina powders of nominal composition 90.40 wt % Al{sub 2}O{sub 3}, 8.85 wt % Na{sub 2}O, and 0.75 wt % Li{sub 2}O. A series of 100 gram samples of the commercial {beta}{double prime}-alumina powder were mixed with 0.2 wt % of one of the oxides of germanium (GeO{sub 2}), magnesium (MgO), niobium (Nb{sub 2}O{sub 5}), or zinc (ZnO). Ionic conductivity measurements were performed in the frequency range of 1 Hz to 1 MHz under an argon atmosphere in a quartz furnace, from ambient to 350{degree}C. After analysis by ac impedance, the ceramic electrolytes were notched and fractured for microstructural analysis by optical and scanning electron microscopy. 4 figs.
Third International Conference on Peer-to-Peer Computing (P2P 2003), 1-3 September, 2003, Linköping, Sweden : Proceedings (2004)

Third International Conference on Peer-to-Peer Computing (P2P 2003), 1-3 September, 2003, Linkoping, Sweden : Proceedings
Parameterized Circuit Modeling of Planar Transmission Line Structures on Arbitrary Substrates (2002)

A new automated circuit-modeling tool is presented for arbitrary planar transmission lines. The tool builds compact, parameterized, analytical models based on multiple full-wave 2D electro-magnetic (EM) simulations. The transmission line parameters are stored as a multidimensional function of frequency and geometrical parameters. The modeling algorithm combines adaptive data selecting and modeling techniques. The circuit models combine EM-accuracy and generality, and circuit simulation speed and flexibility.
Targeting the CD22 Receptor with RNA Damaging Agents (2002)

CD22, a B lymphocyte-restricted member of the immunoglobulin superfamily (IgSF), is a member of the sialoadhesin family of adhesion molecules that includes sialoadhesin and myelin-associated glycoprotein (1). Sialoadhesin and CD22 mediate cellular interactions by recognizing specific cell-surface sialylated glycoconjugates (2and refs. therein). Binding of CD22 to glycoconjugates on neighboring cells alters signaling through the membrane immunoglobulin of B cells by binding cytosolic proteins (3). CD22 is an attractive molecular target because of its restricted expression; it is not exposed on embryonic stem or pre-B cells nor is it normally shed from the surface of antigen-bearing cells (4). Moreover, it is highly expressed on B cells in approx 70–80% of non-Hodgkin’s lymphoma (NHL) cases.
Recent Progress in Clinical Magnetic Resonance Spectroscopy (1996)

Clinical magnetic resonance spectroscopy (MRS) provides the ability to diagnose and monitor disease-progression and response to therapy or to otherwise advance the understanding of the disease in individual patients based on the chemical information content of an MRS examination performed in vivo. Numerous technical advances have contributed to the field and have answered the stringent requirement for reproducibility of such measurements between cohorts of patients across different manufacturer platforms and in physically separate hospitals and medical centers. The present review identified 15 organs and tissues for which clinical MRS can define a wide range of diseases. Evidence-based medicine criteria have not yet been established for MRS as applied in each anatomical location, organ, and disease. Work to establish “standard operating procedures” for clinical MRS is well advanced for neurological disease, prostate and breast cancer, liver, skeletal, and cardiac muscle examinations. A notable development for clinical MRS is the recognition that elevated tissue content of “choline” and its metabolites constitutes a near-universal cancer marker with the potential of matching or exceeding the excellence currently enjoyed by fluorodeoxy-D-glucose positron emission tomography (FDG-PET) as a clinical scanning procedure. Great promise is seen in newer MRS methodologies just coming “on-line” in the clinic, particularly ultrahigh-field 7-T MR scanners and helium, xenon, and carbon hyperpolarization.
A prospective 5-year study on the use of transient elastography to monitor the improvement of non-alcoholic fatty liver disease following bariatric surgery (2021)

Liver stiffness measurement (LSM) by transient elastography (TE) is a non-invasive assessment for diagnosing and staging liver fibrosis in non-alcoholic fatty liver disease (NAFLD). Evidence on its role as a longitudinal monitoring tool is lacking. This study aims to evaluate the role of TE in monitoring NAFLD improvement following bariatric surgery. This study prospectively recruited 101 morbidly obese patients undergoing laparoscopic bariatric surgery for intraoperative liver biopsy. Thirty-seven patients of the cohort received perioperative TE. Postoperative anthropometric, biochemical and LSM data were collected annually for 5 years. In 101 patients receiving liver biopsy (mean age 40.0 ± 10.3 years, mean body-mass-index (BMI) 40.0 ± 5.7 kg/m<sup>2</sup>), NASH and liver fibrosis were diagnosed in 42 (41.6%) and 48 (47.5%) patients respectively. There were 29 (28.7%) stage 1, 11 (10.9%) stage 2, 7 (6.9%) stage 3, and 1 (1.0%) stage 4 fibrosis. In 37 patients receiving TE (mean age 38.9 ± 10.8 years, mean BMI 41.1 ± 5.6 kg/m<sup>2</sup>), the percentages of total weight loss were 21.1 ± 7.6% at 1 year, 19.7 ± 8.3% at 3 years, and 17.1 ± 7.0% at 5 years after surgery. The mean LSM reduced significantly from 9.8 ± 4.6 kPa at baseline to 6.9 ± 3.4 kPa at 1 year, 7.3 ± 3.0 kPa at 3 years, and 6.8 ± 2.6 kPa at 5 years (P = 0.002). Using pre-defined LSM cut-offs, the rates of significant fibrosis, advanced fibrosis and cirrhosis being ruled out at 5 years improved from baseline values of 43.7 to 87.5% (P < 0.001), 56.8 to 91.7% (P < 0.001), and 64.9 to 91.7% (P < 0.001), respectively. TE was a useful monitoring tool in demonstrating the improvement of liver fibrosis following bariatric surgery.
Novel miniature wearable microstrip antennas for ISM-band biomedical telemetry (2015)

This paper presents two innovative designs of miniature wearable microstrip antennas for biotelemetry in the Industrial, Scientific, and Medical (ISM) band (2.4-2.48GHz). The two proposed designs employ stacked triangular guiding patches as well as slotting of the patches. This results in a considerable size reduction of 60% with respect to the original antenna volume. Both designs have dimensions of of 39 × 39 × 2.1 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> . Simulations of the two proposed designs have been carried out using HFSS for S-parameters, Specific Absorption Rate (SAR), and E-field distribution, on an equivalent human body phantom. Results demonstrate a return loss of -16.69 dB, and -15.53 dB for the stacked and stacked-slotted triangular patches, respectively. Furthermore, the maximum SAR value obtained from both designs satisfy the IEEE standard safety guidelines, which is necessary for ensuring patient safety. This makes the two proposed antenna designs great candidates for WBAN applications.
Controlling deformable material with dynamic morph targets (2009)

We present a method to control the behavior of elastic, deformable material in a dynamic simulation. We introduce dynamic morph targets, the equivalent in dynamic simulation to the geometric morph targets in (quasi-static) modeling. Dynamic morph targets define the pose-dependent physical state of soft objects, including surface deformation and elastic and inertial properties. Given these morph targets, our algorithm then derives a dynamic model that can be simulated in time-pose-space, interpolating the dynamic morph targets at the input poses. Our method easily integrates with current modeling and animation pipelines: at different poses, an artist simply provides a set of dynamic morph targets. Whether these input states are physically plausible is completely up to the artist. The resulting deformable models expose fully dynamic, pose-dependent behavior, driven by the artist-provided morph targets, complete with inertial effects.
HiSIM-LDMOS/HV: A Complete Surface-Potential-Based MOSFET Model for High Voltage Applications (2008)

We present here the high-voltage MOSFET model HiSIM-LDMOS/HV based on the complete surfacepotential description. The model is valid both for symmetrical and asymmetrical device structures, has accurate scaling properties for structural variations such as gate wide, gate length or drift-region length and is valid for a wide range of bias conditions. The predictability of the developed model is discussed with examples of various device parameter variations.
Novel Mass Spectrometric Method for Phosphorylation Quantification Using Cerium Oxide Nanoparticles and Tandem Mass Tags (2012)

The stoichiometry of protein phosphorylation significantly impacts protein function. The development of quantitative techniques in mass spectrometry has generated the ability to systematically monitor the regulation levels of various proteins. This study reports an integrated methodology using cerium oxide nanoparticles and isobaric tandem mass tag (TMT) labeling to assess absolute stoichiometries of protein phosphorylation. This protocol was designed to directly measure the dephosphorylation levels for a known phosphorylation site, therefore allowing for quantification of phosphosites. Both the accuracy and precision of the method were verified using standard peptides and protein tryptic digests. This novel method was then applied to quantify phosphorylations on eukaryotic initiation factor 3H (eIF3H), a protein integral to overall eukaryotic protein translation initiation. To date, this is the first report of assessment of protein phosphorylation quantification on eIF3.