gebhart/patrepeval huggingface dataset:
Prospective Evaluation of PSMA-Targeted 18F-DCFPyL PET/CT in Men with Biochemical Failure After Radical Prostatectomy for Prostate Cancer (2019)

Our purpose is to provide the results of a prospective study evaluating prostate-specific membrane antigen-targeted <sup>18</sup>F-DCFPyL (2-(3-{1-carboxy-5-[(6-<sup>18</sup>F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid) PET/CT in patients with biochemical failure after radical prostatectomy for prostate cancer (PCa). <b>Methods:</b> Thirty-one patients with postprostatectomy serum prostate-specific antigen (PSA) levels of at least 0.2 ng/mL and negative conventional imaging results were enrolled in this study and imaged with <sup>18</sup>F-DCFPyL PET/CT. A consensus central review identified foci of radiotracer uptake consistent with sites of PCa. Descriptive statistics were used. <b>Results:</b> Twenty-one patients (67.7%) had at least 1 finding on <sup>18</sup>F-DCFPyL PET/CT consistent with a site of PCa. Imaging was positive in 59.1% of patients with a PSA level of less than 1.0 ng/mL and in 88.9% of patients with a PSA level of more than 1.0 ng/mL. The median SUV<sub>max</sub> across all lesions was 11.6 (range, 1.5-57.6). <b>Conclusion:</b> In this prospective study using the prostate-specific membrane antigen-targeted PET agent <sup>18</sup>F-DCFPyL, most patients with biochemical failure after radical prostatectomy had foci of suggestive uptake, even at low serum PSA levels.
Supplementary Data from Association of Inflammation-Related and microRNA Gene Expression with Cancer-Specific Mortality of Colon Adenocarcinoma (2023)

Supplementary Data from Association of Inflammation-Related and microRNA Gene Expression with Cancer-Specific Mortality of Colon Adenocarcinoma
Supplementary Figure 1 from 3,5-Bis(2,4-Difluorobenzylidene)-4-piperidone, a Novel Compound That Affects Pancreatic Cancer Growth and Angiogenesis (2023)

&lt;p&gt;PDF file - 159K&lt;/p&gt;
Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network (2021)

Procurement of research tissue should be considered feasible, accompanied by a complication risk likely no greater than that incurred for standard clinical purposes. In the quest for targeted treatments personalised based on molecular findings, enhanced diagnostics beyond histology will likely be required.
Systems design of a high resolution retinal prosthesis (2008)

Simulations of artificial vision suggest that 1000 electrodes may be required to restore vision to individuals with diseases of the outer retina. In order to achieve such an implant, new technology is needed, since the state-of-the-art implantable neural stimulator has at most 22 contacts with neural tissue. Considerable progress has been made towards that goal with the development of image processing, microelectronics, and polymer based MEMS. An image processing system has been realized that is capable of real-time implementation of image decimation and filtering (for example, edge detection). Application specific integrated circuits (ASICs) have been designed and tested to demonstrate closed loop power control and efficient microstimulation. A novel packaging process has been developed that is capable of simultaneously forming communication coils, interconnects, and stimulating electrodes.
Indoor wideband radiowave propagation measurements at 1.3 GHz and 4.0 GHz (1990)

Measured impulse response estimates of radio channels have been used to determine time delay spread and path loss characteristics inside four buildings using different antenna heights at 1.3 GHz and 4.0 GHz. RMS delay spread values were found to be dependent on building and local topography, but generally independent of frequency and antenna height. Path loss values were found to be nearly independent of frequency.
Models for the Compressible Web (2013)

Graphs resulting from human behavior (the web graph, friendship graphs, etc.) have hitherto been viewed as a monolithic class of graphs with similar characteristics; for instance, their degree distributions are markedly heavy tailed. In this paper we take our understanding of behavioral graphs a step further by showing that an intriguing empirical property of web graphs---their compressibility---cannot be exhibited by well-known graph models for the web and for social networks. We then develop a more nuanced model for web graphs and show that it does exhibit compressibility, in addition to previously modeled web graph properties.
Thin Films of Block Copolymer−Homopolymer Blends with a Continuously Tunable Density of Spherical Microdomains (2010)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTThin Films of Block Copolymer−Homopolymer Blends with a Continuously Tunable Density of Spherical MicrodomainsJohn M. Papalia†‡, Andrew P. Marencic†, Douglas H. Adamson‡⊥, Paul M. Chaikin‡§, and Richard A. Register*†‡View Author Information† Department of Chemical and Biological Engineering‡ Princeton Institute for the Science and Technology of Materials, Princeton University, Princeton, New Jersey 08544⊥ Department of Chemistry and Institute of Materials Science, University of Connecticut, Storrs, Connecticut, 06269§ Department of Physics, New York University, New York, New York 10003*Corresponding author. E-mail: [email protected]Cite this: Macromolecules 2010, 43, 17, 6946–6949Publication Date (Web):August 6, 2010Publication History Received30 June 2010Revised30 July 2010Published online6 August 2010Published inissue 14 September 2010https://pubs.acs.org/doi/10.1021/ma101458mhttps://doi.org/10.1021/ma101458mrapid-communicationACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views825Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Homopolymers,Layers,Micelles,Thickness,Thin films Get e-Alerts
High expression and anterograde axonal transport of aminoterminal sonic hedgehog in the adult hamster brain (2001)

Sonic hedgehog (SHH) is considered to play an important role in tissue induction and patterning during development, particularly in determining neuronal cell fate in the ventral neural tube and in the embryonic forebrain. SHH precursor is autoproteolytically cleaved to an aminoterminal fragment (SHHN) which retains all known SHH biological activities. Here, we demonstrate the expression of a 22-kDa SHHN immunoreactive peptide in developing and adult hamster brain regions using a rabbit antiserum directed against a mouse SHHN fragment. Interestingly, SHHN was developmentally regulated with the highest expression observed in the adult brain, was resistant to Triton X-100 solubilization at 4 degrees C and partitioned with the raft component ganglioside GM1 during density gradient centrifugation. In rat brain, Shh transcripts were identified by double in situ hybridization in GABAergic neurons located in various basal forebrain nuclei including globus pallidus, ventral pallidum, medial septum-diagonal band complex, magnocellular preoptic nucleus and in cerebellar Purkinje cells as well as in motoneurons of several cranial nerve nuclei and of the spinal cord. We show that radiolabelled SHHN peptides are synthesized in the adult hamster retina and are transported axonally along the optic nerve to the superior colliculus in vivo. Our data indicate that SHHN is associated with cholesterol rich raft-like microdomains and anterogradely transported in the adult brain, and suggest that the roles of this extracellular protein are more diverse than originally thought.
Prenatal immune activation and subsequent peripubertal stress as a new model of schizophrenia (2013)

Epidemiological studies show that maternal viral infection during pregnancy plays a key role in the etiology of neurodevelopmental disorders, such as schizophrenia and autism. Prenatal maternal immune activation and peripubertal psychological stress are key environmental risk factors for neurodevelopmental disorders. Viral mimic polyriboinosinic-polyribocytidylic acid is known to act as a Toll-like receptor-3 agonist. Polyriboinosinic-polyribocytidylic acid has been typically used to establish this rodent model of prenatal immune activation. Recently, Giovanoli et al. reported on a new neurodevelopmental model of schizophrenia based on combined prenatal immune activation and peripubertal stress. In this report, we place these findings into context and discuss their significance.
Green’s-function approach to the electronic structure of double-barrier quantum-well heterostructures (1994)

The scattering-theoretic Green's-function method incorporated with band structures, which takes into account the indirect band gap, the band nonparabolicity, and the multiorbital and external-bias effect, is used to study AlAs/GaAs/AlAs double-barrier quantum-well structures in a [001] direction. The calculated spectral local density of states simultaneously exhibits confined states originating from both the quantum-well \ensuremath{\Gamma} valley and the barrier X valley. The calculated energies of confined quantum-well electron states and light-hole states are compared with the reported photoluminescence-excitation experimental data.
Design of robust global power and ground networks (2001)

We consider the problem of determining optimal wire widths for a power or ground network, subject to limits on wire widths, voltage drops, total wire area, current density, and power dissipation. To account for the variation of the current demand, we model it as a random vector with known statistics, possibly including correlation between subsystem currents. Other researchers have shown that when the variation in the current is not taken into account, the optimal network topology is a tree. A tree topology is, however, almost never used in practice, because it is not robust with respect to variations in the lock currents. We show that when the current variation is taken into account, the optimal network is usually not a tree.
At the Interface of Organic and Inorganic Chemistry:  Bioinspired Synthesis of Composite Materials (2001)

The design of artificial models of the processes of biomineralization has resulted in the union of inorganic materials research and supramolecular organic chemistry. Recent work in this field of bioinspired synthesis of composite organic/inorganic materials is reviewed and prospects for the future are discussed. Attention is focused on the use of self-assembled organic superstructures to template inorganic materials with controlled morphologies.
Active material reversible attachments: shape memory polymer based (2008)

We detail the joint concept generation and embodiment development by HRL and GMR&D of shape memory
polymer (SMP) based reversible-on-demand attachments. In this initial study of active material enabled
reversible-on-demand attachments, our primary focus was on hook-and-loop type fasteners. The approach
followed, in broader context, was to incorporate an active material, defined as a material which changes a
fundamental mechanical property upon exposure to an appropriate field, in at least one component of the
hook-and-loop assembly, in this way allowing a field activated change in the stiffness (raising/lowering)
and/or geometry (straightening of the hook) of the component and thus on-demand release of the attachment
This paper describes the fabrication method and properties of one of the two principle classes of
embodiments made during the development of the concept. This class of embodiments, which utilized
thermally activated shape memory polymer materials, was shown to exhibit pull-off forces similar to
conventional non-active hook-and-loop fasteners, and significantly, as desired, was reversible with a
reduction in the pull-off force of a factor of ~100. This study was thus successful in demonstrating the
feasibility of a thermally activated SMP based reversible-on-demand distributed attachment.
Surface Modification of Carbon Nanotube by Poly(ethylene glycol) for the Preparation of Poly(vinyl alcohol) Nanocomposite (2010)

Herein, PEGylated multi-walled carbon nanotube (MWNT) was prepared for the successive fabrication of poly(vinyl alcohol) PVA/MWNT nanocomposite film by solution casting. The surface modified MWNT showed a good colloidal stability in a polar solvent, i.e., water. Also, the PEGylated MWNT had an improved dispersion stability in aqueous PVA solution. The mixture of PEGylated MWNT and PVA dissolved in water was film casted and the dispersion uniformity and corresponding improvement of electrical conductivity were investigated. The electrical conductivity of PVA/modified MWNT composite film was three-fold higher than that of PVA/pristine MWNT composite film due to the much improved distribution uniformity of modified MWNT in PVA matrix.
Development of a transillumination infrared modality for differential vasoactive optical imaging (2009)

We present the development and implementation of a new near infrared transillumination imaging modality for tissue imaging. Exogenous inhaled hyperoxic and hypercarbic gases are used as "vasoactive contrast agents" via the production of changes in concentration of the endogenous HbO(2) and Hb in blood. This vasoactive differential imaging method is employed to acquire data and for subsequent image analysis. Spectroscopic changes obtained from transillumination measurements on the palms of healthy volunteers demonstrate the functionality of the imaging platform. This modality is being developed to monitor suspect breast lesions in a clinical setting based on the hypothesis that the atypical tumor vascular environment will yield sufficient contrast for differential optical imaging between diseased and healthy tissue.
Phantom Testing of Peripheral Artery Absolute Blood Flow Measurement With Digital Arteriography (1985)

A technique to measure absolute arterial blood flow in ml/min has been developed utilizing software programs with high-speed digital recording for the off-line analysis of intra-arterial injections of contrast medium. Measurements of pulsatile flow in a phantom for a physical flow model showed that calculations with the final upgrades were within 10% of known flow, using a recording rate of 30 frames/s, a diameter tubing of 5 mm, and flow rates of 300 to 400 ml/min. Quantitative absolute flow of a peripheral artery such as the internal carotid artery may be obtained during routine cerebral arteriography for comparison with anatomic data.
Epidermal growth factor receptor as a molecular determinant of glioblastoma response to dopamine receptor D2 inhibitors (2020)

High EGFR expression is a determinant of poor glioblastoma response to DRD2. This finding should inform future clinical trial designs.
An aqueous base developable novel deep-UV resist for KrF excimer laser lithography. (1991)

A positive deep-UV resist consisting of silylated polyhydroxystyrene and photoacid generator was investigated. Optimization of the polymer structure has been achieved from the points of silylating substituent and silylation ratio. The resist is capable of imaging 0.3μm line and space pairs in a 1.05μm thick film by using a KrF excimer laser stepper (NA=0.42) with practical sensitivity of 20mJ/cm2. It has been also shown that the resist is workable as a top layer in a bi-layer process.
A new route to the isoindole nucleus via Furan–pyrrole ring-exchange (1994)

M. Lee, H. Moritomo and K. Kanematsu, J. Chem. Soc., Chem. Commun., 1994, 1535 DOI: 10.1039/C39940001535
Effect of Test System on the Ability of Monoclonal Antibodies to Detect Antigenic Drift in Influenza A (H1N1) Virus Haemagglutinins (1981)

Results of analysing antigenic variation in the haemagglutinin (HA) molecule of naturally occurring influenza A (H1N1) viruses from 1977 to 1979 with monoclonal antibodies were found to be dependent in some instances on the test system used. In several instances A/USSR/90/77 HA-specific monoclonal antibodies had sharply reduced haemagglutination-inhibition (HI) titres with variant virus although they bound to the variant and A/USSR/90/77 HAs with similar efficiencies as judged by titration in a sensitive and accurate solid-phase immunofluorimetric assay. In another instance, the converse situation was observed: monoclonal antibodies having a reduced efficiency of binding to the HA of a variant virus nevertheless had comparable HI titres with the variant and with A/USSR/90/77. The chemical basis and epidemiological significance of these observations remain to be elucidated. Nevertheless, the finding that the reaction of monoclonal antibodies can, in some cases, be markedly dependent on the test system employed is of significance for the efficient design and correct interpretation of immunochemical studies which employ monoclonal antibodies to investigate the basis for variation in influenza strains.
A tunable integrated duplexer with 50dB isolation in 40nm CMOS (2009)

Modern RF duplexers rely on frequency-selective filters for isolation. The stringent isolation requirements prohibit the integration of RF duplexers on silicon and particularly in CMOS technology. However, CMOS technology offers superior tuning and calibration capabilities supported by the integrated digital baseband. This work presents the first integrated duplexer in CMOS technology with an adequate performance for full-duplex cellular applications such as WCDMA and HSPA. The proposed implementation is based on electrical balance of a hybrid transformer rather than frequency selectivity which unfavorably requires high-Q elements.
Current status and perspectives in the development of therapeutic agents targeting post-ischemic inflammation in the acute stage of stroke (2020)

We have developed a partial peptide of RANKL (receptor activator of NF-κB ligand) that suppresses TLR (toll-like receptor)-related inflammation via RANKL/RANK (receptor activator of nuclear factor-κB) signals in the acute phase of ischemic stroke. This peptide has been found to be a therapeutic agent for ischemic stroke that can be used in combination with tPA in a mouse model. Based on the findings, we are working on translational research to aim for clinical application of this peptide through collaboration with pharmacy companies. However, the problem is that the need for development of medication in the acute stage of ischemic stroke is currently low in pharmaceutical companies due to the failure of many investigational drugs in the past. To overcome the problem, we are examining the effects of this peptide in other diseases included in the company's priority areas and explaining the environmental changes in the clinical trials due to the development of endovascular treatment in the acute stage of ischemic stroke.
Contextual phrase-level polarity analysis using lexical affect scoring and syntactic N-grams (2009)

We present a classifier to predict contextual polarity of subjective phrases in a sentence. Our approach features lexical scoring derived from the Dictionary of Affect in Language (DAL) and extended through WordNet, allowing us to automatically score the vast majority of words in our input avoiding the need for manual labeling. We augment lexical scoring with n-gram analysis to capture the effect of context. We combine DAL scores with syntactic constituents and then extract n-grams of constituents from all sentences. We also use the polarity of all syntactic constituents within the sentence as features. Our results show significant improvement over a majority class baseline as well as a more difficult baseline consisting of lexical n-grams.
Modified polymers for gas chromatography (1979)

Polymeric materials are modified to serve as stationary phase in chromatographic columns used for separation of atmospheric gases. Materials simplify and improve separation of atmospheric gases in terms of time, quantity of material needed, and sharpness of separation.
Chemical Degradation Pathways in Siloxane Polymers Following Phenyl Excitations (2018)

We use ensembles of quantum-based molecular dynamics simulations to predict the chemical reactions that follow radiation-induced excitations of phenyl groups in a model copolymer of polydimethylsiloxane and polydiphenylsiloxane. Our simulations span a wide range of highly porous and condensed phase densities, and include both wet and dry conditions. We observe that in the absence of water, excited phenyl groups tend to abstract hydrogen from other methyl or phenyl side groups to produce benzene, with the under-hydrogenated group initiating subsequent intrachain cyclization reactions. These systems also yield minor products of diphenyl moieties formed by the complete abstraction of both phenyl groups from a single polydiphenylsiloxane subunit. In contrast, we find that the presence of water promotes the formation of free benzene and silanol side groups, reduces the likelyhood for intrachain cyclization reactions, and completely suppresses the formation of diphenyl species. In addition, we predict that water plays a critical role in chain scission reactions, which indicates a possible synergistic effect between environmental moisture and radiation that could promote alterations of a larger polymer network. These results could have impact in interpreting accelerated aging experiments, where polymer decomposition reactions and network rearrangements are thought to have a significant effect on the ensuing mechanical properties.&lt;br&gt;
Compact Yb fiber few-cycle pulse source based on precision pulse compression and shaping with an adaptive fiber Bragg grating (2023)

We generate bandwidth limited 10 µJ pulses of 92 fs pulse width using an adaptive fiber Bragg grating stretcher (FBG) in conjunction with a Lyot filter. The temperature controlled FBG is used to optimize the group delay, whereas the Lyot filter counteracts gain narrowing in the amplifier chain. Soliton compression in a hollow core fiber (HCF) allows for access to the few-cycle pulse regime. Adaptive control further enables the generation of nontrivial pulse shapes.
In this issue of the International Reviews of Immunology (2012)

This issue hosts diverse topics, from myeloid derived suppressor cells (MDSC) with their mechanism and role in cancer, the interplay between diet and emerging allergies studied in a genetically closed population, the pleiotropic anti-inflammatory effects of resveratrol, to the quest to achieve more reliable immune correlates of protection against the hepatitis C virus (HCV).