gebhart/patrepeval huggingface dataset:
Tandem radical approach to linear condensed cyclopentanoids. Total synthesis of (.+-.)-hirsutene (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTandem radical approach to linear condensed cyclopentanoids. Total synthesis of (.+-.)-hirsuteneDennis P. Curran and Donna M. RakiewiczCite this: J. Am. Chem. Soc. 1985, 107, 5, 1448–1449Publication Date (Print):March 1, 1985Publication History Published online1 May 2002Published inissue 1 March 1985https://pubs.acs.org/doi/10.1021/ja00291a077https://doi.org/10.1021/ja00291a077research-articleACS PublicationsRequest reuse permissionsArticle Views3825Altmetric-Citations148LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Identification of oligopeptide sequences which inhibit migration induced by a wide range of chemokines (1999)

We have identified an amino acid sequence, termed peptide 3, corresponding to amino acids 51-62 of the mature human monocyte chemoattractant protein-1 (MCP-1), which inhibits human mononuclear-cell and THP-1-cell migration induced by a wide range of chemokines. For example, peptide 3 inhibited MCP-1-induced THP-1 migration in a transwell assay with an ED50 of approx. 8 μM. Peptide 3 binds directly to THP-1 cells with an association constant of approx. 10 μM, and is therefore likely to be a direct receptor antagonist for CC and CXC chemokine receptors. By performing a structure-function analysis of this peptide, we have identified a sequence variant that shows an approx. 3-4-fold greater potency as an inhibitor of chemokine-induced migration [Leu4Ile11 peptide 3 (1-12)]. Furthermore, unlike peptide 3, which binds to the Duffy antigen receptor for chemokines on human erythrocytes with a similar affinity to the specific chemokine receptors on THP-1 cells, the Leu4Ile11 peptide 3 (1-12) sequence variant shows at least 20-fold greater selectivity for the specific receptors. Derivatives of Leu4Ile11 peptide 3 (1-12) are therefore the best candidates among the molecules we have investigated for use as a chemokine inhibitor in vivo.
Optimal packing of group multicastings (2002)

This paper presents algorithms, heuristics and lower bounds addressing optimization issues in many-to-many multicasting. Two main problems are addressed: (1) a precise combinatorial comparison of optimal multicast trees with optimal multicast rings, (2) an optimized sharing of network resources (i.e., nodes and links) among multiple multicast groups that coexist. The former is central to the choice of multicast protocols and their performance, while the latter is crucial for network utilization. The first problem is treated as a comparison of Steiner tree and traveling salesman problems on the same input set. The underlying integer programming problems are solved to optimum by using cutting-plane inequalities and the branch-and-cut algorithm. In addition to these exact solutions, fast heuristics are presented for approximate solutions. The second problem is formulated as a packing problem in which the network tries to accommodate all the multicast groups by optimizing the utilization of resources. Precise mathematical programming formulations, lower bounds and a heuristic for the underlying optimization problem are presented. The heuristic aims to accommodate multiple multicast groups while avoiding bottlenecks on the links for higher throughput. The heuristics and exact algorithms are implemented on various networks and multicast groups. The simulations show that multicast trees can be built by using 25% fewer links than the rings, both for optimal and suboptimal constructions. The packing heuristic is also implemented and its performance is compared to the constructive lower bound.
Transplant rejection and paradigms lost (2013)

During transplant rejection, migrating T cells infiltrate the grafted organ, but the signals that direct this migration are incompletely understood. In this issue of the JCI, Walch et al. debunk two classical paradigms concerning transplant rejection, with important consequences for the design of antirejection therapeutics.
Development and Evaluation of an Air-Curtain Fume Cabinet with Considerations of its Aerodynamics (2006)

In order to avoid the inherent aerodynamic difficulties of the conventional fume hood, an innovative design--the 'air curtain-isolated fume hood' is developed. The new hood applies a specially designed air curtain (which is generated by a narrow planar jet and a suction slot flow at low velocities) across the sash plane. The hood constructed for the study is full size and transparent for flow visualization. The aerodynamic characteristics are diagnosed by using the laser-light-sheet-assisted smoke flow visualization method. Four characteristic air-curtain flow modes are identified in the domain of jet and suction velocities when the sash remains static. Some of these characteristic flow modes have much improved flow patterns when compared with those of the conventional fume hoods. From the viewpoint of the aerodynamics and mass transport, the results indicate that the air curtain properly setup across the sash opening allows almost no sensible exchange of momentum and mass between the flowfields of the cabinet and the outside environment. Two standard sulfur hexafluoride (SF6) tracer gas concentration measurement methods following the ANSI/ASHRAE 110-1995 standard and the prEN14175 protocol for static test are employed to examine the contaminant leakage levels. Results of the rigorous examinations of leakage show unusually satisfactory hood performance. The leakage of the tracer gas can approach almost null (<0.001 p.p.m.) if the jet and suction velocities are properly adjusted.
Spinal Cord Stimulation versus Reoperation for Failed Back Surgery Syndrome: A Cost Effectiveness and Cost Utility Analysis Based on a Randomized, Controlled Trial (2007)

SCS was less expensive and more effective than reoperation in selected failed back-surgery syndrome patients, and should be the initial therapy of choice. SCS is most cost-effective when patients forego repeat operation. Should SCS fail, reoperation is unlikely to succeed.
Development and evaluation of AuSi eutectic wafer bonding (2009)

In this paper, wafer-to-wafer AuSi eutectic bonding was investigated and evaluated with various sets of experimental parameters. Single crystalline Si and amorphous Si were bonded with different dimension Au layers and observed by optical measurements. Material composition, adhesion layer, electrical insulation, bonding parameters, and surface pre-treatments were discussed and have improved bonding performance. Bond strength determined by micro-chevron-test and shear test was evaluated as well as hermeticity. High bond yield was achieved with 4 inch and 6 inch wafer stacks.
802.11ax: The Coming New WLAN System with More Than 4x MAC Throughput Enhancement (2017)

This paper introduces a new wireless LAN (WLAN) amendment to IEEE 802.11 WLAN specification. The new amendment is named High Efficiency WLAN (HEW), or IEEE 802.11ax. The new amendment is targeting dense WLAN deployments and deals with known WLAN issues including random channel access and the short packet length of most services. IEEE 802.11ax is intended to operate in the bands extending from 1 GHz to 6 GHz and increases the per-user throughput by 4 times compared to existing WLAN standards operating in the same band.
Removal of Toluene in Gas Streams by a Fibrous-Bed Trickling Filter (2001)

A novel fibrous-bed trickling filter was developed to remove toluene present in contaminated air. Pure culture of Pseudomonas putida F1 was attached on fibrous-bed and utilized toluene as the carbon source. Experimental results indicated the removal efficiency decreased with the increase of inlet concentration. In general, the removal efficiency of toluene was greater than 90% when the inlet loading capacity was below 70 g m-3h-3. The elimination capacity increased with increasing inlet loading capacity, but the increased rate decreased gradually. When the inlet loading capacity increased to 300 g m-3h-1, the elimination capacity could approach to 130 g m-3h-1. The first order kinetics model was useful to describe the removal of toluene in this filter and an excellent linear relationship was found between the apparent first order parameter and inlet concentration (ranging from 1.2 g m-3 to 3.5 g m-3). Also, the performance of fibrous-bed trickling filter was relatively stable during the four-month period of continuous operation. Slight clogging phenomena of filters were observed only under high loading capacity.
Endogenous Ghrelin Regulates Episodic Growth Hormone (GH) Secretion by Amplifying GH Pulse Amplitude: Evidence from Antagonism of the GH Secretagogue-R1a Receptor (2005)

Energy homeostasis is controlled by a complex regulatory system of molecules that affect food intake and that are critical for maintaining a stable body weight during life. Ghrelin is a peptide of 28 amino acid synthesized predominantly by the stomach and the gut, which activate the type 1a growth hormone (GH) secretagogue receptor (GHS-R1a), a G-protein coupled receptor. The acylated form of ghrelin potently stimulates GH secretion both in vitro and in vivo in several animal species, including humans. Beside the endocrine effect, ghrelin shows also extraendocrine activities, including stimulation of feeding behaviour. Several classes of small synthetic peptide and non-peptide ligands of the GHS-R1a have been described and are able to release GH and stimulate food intake. However, in time, it appeared that the stimulating effects on GH secretion could be divorced from those on food intake, suggesting that more than a single receptor might be involved. Several experimental data have even questioned the physiological role of ghrelin in the control of GH secretion and energy metabolism. By using novel agonists, partial agonists, and antagonists for the GHS-R1a receptor, we have studied whether the stimulation of this receptor could account for the purported physiological role of ghrelin. Our results demonstrate that the ability to bind in vitro the GHS-R1a is not predictive of the in vivo biological activity of the compounds and that the endocrine and extraendocrine effects could be mediated also by receptors different from the GHS-R1a.
Data from Intertumoral Heterogeneity of CD3<sup>+</sup> and CD8<sup>+</sup> T-Cell Densities in the Microenvironment of DNA Mismatch-Repair–Deficient Colon Cancers: Implications for Prognosis (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Colorectal cancers with deficient DNA mismatch repair (dMMR) are presumed to uniformly have dense lymphocytic infiltration that underlies their favorable prognosis and is critical to their responsiveness to immunotherapy, as compared with MMR-proficient (pMMR) tumors. We examined T-cell densities and their potential heterogeneity in a large cohort of dMMR tumors.&lt;/p&gt;Experimental Design:&lt;p&gt;CD3&lt;sup&gt;+&lt;/sup&gt; and CD8&lt;sup&gt;+&lt;/sup&gt; T-cell densities were quantified at the invasive margin (IM) and tumor core (CT) in 561 stage III colon cancers (dMMR, &lt;i&gt;n&lt;/i&gt; = 278; pMMR, &lt;i&gt;n&lt;/i&gt; = 283) from a phase III adjuvant trial (N0147). Their association with overall survival (OS) was determined using multivariable Cox analysis.&lt;/p&gt;Results:&lt;p&gt;Although CD3&lt;sup&gt;+&lt;/sup&gt; and CD8&lt;sup&gt;+&lt;/sup&gt; T-cell densities in the tumor microenvironment were higher in dMMR versus pMMR tumors overall, intertumoral heterogeneity in densities between tumors was significantly higher by 30% to 88% among dMMR versus pMMR cancers (&lt;i&gt;P&lt;/i&gt; &lt; 0.0001 for all four T-cell subtypes [CD3&lt;sup&gt;+&lt;/sup&gt;IM, CD3&lt;sup&gt;+&lt;/sup&gt;CT, CD8&lt;sup&gt;+&lt;/sup&gt;IM, CD8&lt;sup&gt;+&lt;/sup&gt;CT]). A substantial proportion of dMMR tumors (26% to 35% depending on the T-cell subtype) exhibited T-cell densities as low as that in the bottom half of pMMR tumors. All four T-cell subtypes were prognostic in dMMR with CD3&lt;sup&gt;+&lt;/sup&gt;IM being the most strongly prognostic. Low (vs. high) CD3&lt;sup&gt;+&lt;/sup&gt;IM was independently associated with poorer OS among dMMR (HR, 4.76; 95% confidence interval, 1.43–15.87; &lt;i&gt;P&lt;/i&gt; = 0.0019) and pMMR tumors (&lt;i&gt;P&lt;/i&gt; = 0.0103).&lt;/p&gt;Conclusions:&lt;p&gt;Tumor-infiltrating T-cell densities exhibited greater intertumoral heterogeneity among dMMR than pMMR colon cancers, with CD3&lt;sup&gt;+&lt;/sup&gt;IM providing robust stratification of both dMMR and pMMR tumors for prognosis. Potentially, lower T-cell densities among dMMR tumors may contribute to immunotherapy resistance.&lt;/p&gt;&lt;/div&gt;
Correlation of melanoma gene expression score with clinical outcomes on a series of melanocytic lesions (2018)

A 23-gene expression signature was recently developed as an adjunct to histopathology to differentiate melanocytic nevi from melanoma. The current study correlated the gene expression signature scores to actual clinical outcomes in cases from the first validation study. RNA was extracted from 127 archival formalin-fixed paraffin-embedded tissue sections of melanocytic lesions. Gene expression was measured using quantitative reverse-transcription polymerase chain reaction, and a weighting algorithm was used to generate a numeric score. Gene expression test results were compared to histopathological diagnoses and development of local recurrence, sentinel lymph node metastases, and distant metastases. Sixty-five lesions were diagnosed histopathologically as melanoma. Fourteen developed metastases. Gene expression test results were malignant in 61 of 65 (93.8%) lesions (including all lesions that metastasized), indeterminate in 2 of 65 (3.1%) lesions, and benign in 2 of 65 (3.1%) lesions. The remaining 62 lesions were diagnosed as benign by histopathology. Gene expression test results were benign in 48 of 62 (77.4%), indeterminate in 7 of 62 (11.3%), and malignant in 7 of 62 (11.3%). There was a strong correlation between the gene expression signature test results and clinical outcomes. All lesions that metastasized were correctly identified by the test as malignant melanoma.
A Graph Theoretic Approach for Training Overhead Reduction in FDD\n Massive MIMO Systems (2018)

The overheads associated with feedback-based channel acquisition can greatly\ncompromise the achievable rates of FDD based massive MIMO systems. Indeed,\ndownlink (DL) training and uplink (UL) feedback overheads scale linearly with\nthe number of base station (BS) antennas, in sharp contrast to TDD-based\nmassive MIMO, where a single UL pilot trains the whole BS array. In this work,\nwe propose a graph-theoretic approach to reducing DL training and UL feedback\noverheads in FDD massive MIMO systems. In particular, we consider a single-cell\nscenario involving a single BS with a massive antenna array serving to\nsingle-antenna mobile stations (MSs) in the DL. We assume the BS employs\ntwo-stage beamforming in the DL, comprising DFT pre-beamforming followed by\nMU-MIMO precoding. The proposed graph-theoretic approach exploits knowledge of\nthe angular spectra of the BS-MS channels to construct DL training protocols\nwith reduced overheads. Simulation results reveal that the proposed\ntraining-resources allocation method can provide approximately 35% sum-rate\nperformance gain compared to conventional orthogonal training. Our analysis\nalso sheds light into the impact of overhead reduction on channel estimation\nquality, and, in turn, achievable rates.\n
Experimental Investigation of Soot Accumulation and Regeneration in a Catalyzed Gasoline Particulate Filter Utilizing Particulate Quantification and Gas Speciation Measurements (2018)

Recent particulate regulations for gasoline passenger cars have prompted the utilization of Gasoline Particulate Filters (GPF’s) to mitigate particulate emissions. This study overviews a comprehensive experimental methodology for examination of essential GPF parameters: spatial exothermic temperature rise, particulate trapping efficiency, and the pressure rise versus particulate loading. A GDI vehicle equipped with a subfloor catalytically washcoated GPF downstream of the three-way catalyst was operated on a chassis dynamometer for data collection. Accelerated soot accumulation procedures were developed to expedite the testing while avoiding passive particulate regeneration based on both particulate concentration and size distributions. Soot concentrations pre and post GPF were used to measure the soot trapping efficiency and total soot accumulation. Fuel-cut coast events, common in real-world driving, were utilized to initiate worst case GPF regenerations, namely regenerations which produce maximum temperature rise due to the limited exhaust flow through the GPF. CO2 measurements simultaneously measured before and after the GPF were examined to calculate the quantity of soot burned during each regeneration event. Thermocouples located inside the GPF were implemented to obtain the spatially disparate, transient temperature traces and analyzed to obtain insights on the soot distribution inside the GPF. The maximum exothermic temperature rise within the GPF was tracked for different soot loadings and regeneration temperatures to ensure GPF substrate and catalytic washcoat health. Most initial soot loadings required multiple ‘fuel-cut coast’ regenerations for complete soot oxidation of all trapped particulate mass. Additionally, externally supplied oxygen was utilized to obtain complete GPF regeneration in a single event. This purpose built system created O2 availability while maintaining constant GPF temperatures, similar to actively commanding lean A/F ratios during vehicle operation. Emissions measurements indicated that this system successfully regenerated all GPF soot. However, due to magnitude disparity between exhaust flow and total exothermic heat released, the thermocouples inside the GPF recorded only minimal exothermic temperature rises, providing confidence that lean active regeneration strategies pose little threat to GPF health.
CuH-Catalyzed Enantioselective Ketone Allylation with 1,3-Dienes: Scope, Mechanism, and Applications (2019)

Chiral tertiary alcohols are important building blocks for the synthesis of pharmaceutical agents and biologically active natural products. The addition of carbon nucleophiles to ketones is the most common approach to tertiary alcohol synthesis but traditionally relies on stoichiometric organometallic reagents that are difficult to prepare, sensitive, and uneconomical. We describe a mild and efficient method for the copper-catalyzed allylation of ketones using widely available 1,3-dienes as allylmetal surrogates. Homoallylic alcohols bearing a wide range of functional groups are obtained in high yield and with good regio-, diastereo-, and enantioselectivity. Mechanistic investigations using density functional theory (DFT) implicate the in situ formation of a rapidly equilibrating mixture of isomeric copper(I) allyl complexes, from which Curtin-Hammett kinetics determine the major isomer of the product. A stereochemical model is provided to explain the high diastereo- and enantioselectivity of this process. Finally, this method was applied to the preparation of an important drug, ( R)-procyclidine, and a key intermediate in the synthesis of several pharmaceuticals.
Chemical Scent Constituents in the Urine of the Red Fox ( Vulpes vulpes L.) During the Winter Season (1978)

Four volatile chemical compounds have been identified as apparently unique constituents in urines of red foxes (both sexes) during the winter season when mating occurs. Quinaldine was found only in male fox urine. Several other compounds identified are found in other species also. Some or all of these compounds may function in olfactory communication in the red fox.
A reference panel of 64,976 haplotypes for genotype imputation (2015)

We describe a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole genome sequence data from 20 studies of predominantly European ancestry. Using this resource leads to accurate genotype imputation at minor allele frequencies as low as 0.1%, a large increase in the number of SNPs tested in association studies and can help to discover and refine causal loci. We describe remote server resources that allow researchers to carry out imputation and phasing consistently and efficiently.
Development of vaccines and their use in the prevention of fungal infections. (1998)

Vaccine approaches to infectious diseases are widely applied and appreciated. Disciplines such as bacteriology and virology have a rich history of successful vaccine development. The complexity of eukaryotic systems presents additional challenges to the development of vaccines against them. These challenges are being met in the fields of parasitology, and are being revisited for application in oncology. Vaccine opportunities exist in medical mycology. The National Institute of Allergy and Infectious Diseases has held a series of workshops in medical mycology where the need to develop vaccines for fungal diseases was noted and where important opportunities were discussed. Major advances in vaccinology and the technology of antigen preparation and delivery have increased feasibility and heightened interest. The recent epidemic of coccidioidomycosis in the American Southwest has demonstrated the need for developing a vaccine as an effective preventive measure for those living in and for those who subsequently move into regions with the endemic mycoses. The XIIth Congress of the International Society for Human and Animal Mycology included a symposium that summarized new vaccination strategies for selected fungi: Candida albicans, Coccidioides immitis, and Trichophyton verrucosum. The goal of the present summary is to provide representative examples of continuing efforts relating to vaccine development within the medical mycological community highlighting Blastomyces dermatidis, Cryptococcus neoformans, Histoplasma capsulatum, Paracoccidioides brasiliensis, and Pythiumn insidiosum.
Encoding Object-oriented Datatypes in HOL: Extensible Records Revisited (2010)

We briefly present the theorem proving environment HOL-OCL. The HOL-OCL system is an interactive proof environment for object-oriented (i.e., UML/OCL) specifications that is build on top of Isabelle/HOL. Overall, we introduce the overall system architecture and, in more detail, our extensible encoding of object-oriented data models into HOL.While our extensible encoding is inspired by the extensible record package of Isabelle/HOL, its implementation is not directly based on it. In this talk, we will discuss how our approach differs from the existing one and discuss how it serves as a basis for implementing allows for implementing Isabelle-based tools for object-oriented models.