gebhart/patrepeval huggingface dataset:
Diagnostic, prognostic, and therapeutic implications of genetic profiling in pleural mesothelioma (2023)

Pleural mesothelioma (PM) is an aggressive malignancy of the pleural lining that typically arises secondary to asbestos exposure. With the advent of next-generation sequencing, major progress has been made in the molecular characterization of pleural mesothelioma over the past three decades. However, these advances have been largely unable to identify effective targeted therapies for PM. Additionally, there remains an absence of accepted gold-standard consensus for staging and treatment, which partly explains the overall poor outcomes in patients with PM. In recent years, genetic profiling of PM tumors has proved to be an effective tool in the diagnosis and prognosis of PM. Genomic sequencing has identified several potential targets for the development of novel therapeutics in PM. This review summarizes the progress in diagnosis, prognosis, and therapeutics derived by genomics and tumor profiling of PM tumors.
Concept-Based Approach to Word-Sense Disambiguation (2021)

The task of automatically determining the correct sense of a polysemous word has remained a challenge to this day. In our research, we introduce Concept-Based Disambiguation (CBD), a novel framework that utilizes recent semantic analysis techniques to represent both the context of the word and its senses in a high-dimensional space of natural concepts. The concepts are retrieved from a vast encyclopedic resource, thus enriching the disambiguation process with large amounts of domain-specific knowledge. In such concept-based spaces, more comprehensive measures can be applied in order to pick the right sense. Additionally, we introduce a novel representation scheme, denoted anchored representation, that builds a more specific text representation associated with an anchoring word. We evaluate our framework and show that the anchored representation is more suitable to the task of word-sense disambiguation (WSD). Additionally, we show that our system is superior to state-of-the-art methods when evaluated on domain-specific corpora, and competitive with recent methods when evaluated on a general corpus.
Link-level performance of an LTE UE receiver in synchronous and asynchronous networks (2013)

The downlink link-level performance assessment, through simulations, is given in this paper for an LTE (and LTE-A) UE receiver, in interference-limited scenarios, and in the presence of RF impairments for both synchronous and asynchronous networks. The data channel (PDSCH) receiver is based on the linear MMSE filter adapted accordingly to the interference environment through the covariance estimation and its inclusion into the filter calculation. A suboptimum MMSE-based receiver is also derived for the transmit-diversity scheme in presence of interference, showing excellent performance. In the baseband simulator, we have modelled typical RF impairments, AGC/ADC, as well as signal-related estimations, such as UE speed, SINR, channel, covariance, time/frequency offsets. The simulation results show excellent performance for the discussed receiver in the presence of strong other-cell interference and impairments.
High‐contrast, high‐sensitivity aqueous base‐developable polynorbornene dielectric (2012)

Abstract The impact of multifunctional epoxy‐based additives on the crosslinking, photolithographic properties, and adhesion properties of a tetramethyl ammonium hydroxide developable, polynorbornene (PNB)‐based dielectric was investigated. Three different multifunctional epoxy additives were investigated: di‐functional, tri‐functional, and tetra‐functional epoxy compounds. The tetra‐functional epoxy crosslinker enhanced the UV absorbing properties of the polymer at 365 nm wavelength. It was found that the epoxy photo‐catalyst could be efficiently activated without a photosensitizer when the tetra‐functional epoxy was used. The polymer mixture with additional (3 wt %) tetra‐functional epoxy crosslinker and without a UV sensitizer showed improved sensitivity by a factor of 4.7 as compared to a polymer mixture containing the same number of equivalents of non‐UV sensitive epoxy with a UV sensitizer. The contrast improved from 7.4 for the polymer mixture with non‐UV absorbing epoxy and a UV sensitizer to 33.4 for the new formulation with 3 wt % tetra‐functional epoxy and no UV sensitizer. The addition of the tetra‐functional epoxy crosslinker also improved the polymer‐to‐substrate adhesion, which permitted longer development times, and allowed the fabrication of high‐aspect‐ratio structures. Hollow‐core pillars were fabricated in 96‐µm thick polymer films with a depth‐to‐width aspect‐ratio of 14 : 1. The degree of crosslinking in the cured films was studied by nanoindentation and swelling measurements. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Generation and validation of structurally defined antibody–siRNA conjugates (2020)

Gene silencing by RNA interference (RNAi) has emerged as a powerful treatment strategy across a potentially broad range of diseases. Tailoring siRNAs to silence genes vital for cancer cell growth and function could be an effective treatment, but there are several challenges which must be overcome to enable their use as a therapeutic modality, among which efficient and selective delivery to cancer cells remains paramount. Attempts to use antibodies for siRNA delivery have been reported but these strategies use either nonspecific conjugation resulting in mixtures, or site-specific methods that require multiple steps, introduction of mutations, or use of enzymes. Here, we report a method to generate antibody-siRNA (1:2) conjugates (ARCs) that are structurally defined and easy to assemble. This ARC platform is based on engineered dual variable domain (DVD) antibodies containing a natural uniquely reactive lysine residue for site-specific conjugation to β-lactam linker-functionalized siRNA. The conjugation is efficient, does not compromise the affinity of the parental antibody, and utilizes chemically stabilized siRNA. For proof-of-concept, we generated DVD-ARCs targeting various cell surface antigens on multiple myeloma cells for the selective delivery of siRNA targeting β-catenin (CTNNB1). A set of BCMA-targeting DVD-ARCs at concentrations as low as 10 nM revealed significant CTNNB1 mRNA and protein knockdown.
Anti‐androgenic effects of S‐40542, a novel non‐steroidal selective androgen receptor modulator (SARM) for the treatment of benign prostatic hyperplasia (2012)

The current results indicate that S-40542 possesses the prostate-selective SARM activity, suggestive of clinical benefit against benign prostate hyperplasia. THQ compounds may be useful for the research of mode of action of SARMs and for the development of safe SARM antagonists.
Abstract 2867: MDM2 and MDM4 are therapeutic vulnerabilities in malignant rhabdoid tumors (2019)

Abstract Malignant rhabdoid tumors (MRT) are aggressive cancers of early childhood that are largely resistant to traditional therapies. MRT exhibit a remarkably low mutation rate, with no recurrent mutations beyond the defining biallelic inactivating mutation in SMARCB1, a core subunit of the SWI/SNF (BAF) chromatin-remodeling complex. Thus, MRT do not display traditional oncogenic mutations that are amenable to targeted therapies, limiting their use for this disease. In order to nominate new drug targets for MRT, we screened MRT cell lines with large-scale RNAi, CRISPR-Cas9, and small-molecule libraries. The most significant vulnerabilities consistent across all three screens were MDM2 and MDM4, the major negative regulators of p53. We found that MRT cell lines are more sensitive than other p53 wild-type cancer cell lines to both idasanutlin (MDM2-specific) and ATSP-7041 (MDM2/4-dual) in vitro. Both inhibitors induced substantial activation of the p53 pathway in MRT cell lines, which responded with permanent apoptotic or senescent cell fate decisions. CRISPR-Cas9-mediated inactivation of TP53 caused a significant resistance to these compounds, confirming that on-target mechanisms were responsible for MRT sensitivity. We found that loss of SMARCB1 sensitizes MRT cells to idasanutlin by shifting the p53 response towards apoptosis. In MRT xenograft studies, both idasanutlin and ATSP-7041 slowed tumor growth. Most strikingly, an idasanutlin pulse of only five days was sufficient to induce sizable regression of all tumors, which remained complete and durable in 50% of mice. Finally, gene expression analysis of primary MRT predicts that, like cell lines and xenografts, MRT in patients are likely to be sensitive to MDM2 inhibition. Collectively, these studies describe a genetic link between SWI/SNF complex mutations and p53, while providing evidence to support the use of MDM2 and MDM2/4 inhibitors that have already entered clinical trials for the treatment of this devastating pediatric cancer. Citation Format: Thomas P. Howard, Taylor E. Arnoff, Melinda R. Song, Andrew O. Giacomelli, Xiaofeng Wang, Andrew L. Hong, Neekesh V. Dharia, Su Wang, Francisca Vazquez, Minh-Tam Pham, Ann M. Morgan, Franziska Wachter, Gregory H. Bird, Guillaume Kugener, Elaine M. Oberlick, Matthew G. Rees, Hong Tiv, Justin H. Hwang, Katherine H. Walsh, April Cook, John M. Krill-Burger, Aviad Tsherniak, Prafulla C. Gokhale, Peter J. Park, Kimberly Stegmaier, Loren D. Walensky, William C. Hahn, Charles W. Roberts. MDM2 and MDM4 are therapeutic vulnerabilities in malignant rhabdoid tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2867.
Towards the Standardization of Non-orthogonal Multiple Access for Next Generation Wireless Networks (2018)

Non-orthogonal multiple access (NoMA) as an efficient way of radio resource sharing can root back to the network information theory. For generations of wireless communication systems design, orthogonal multiple access (OMA) schemes in time, frequency, or code domain have been the main choices due to the limited processing capability in the transceiver hardware, as well as the modest traffic demands in both latency and connectivity. However, for the next generation radio systems, given its vision to connect everything and the much evolved hardware capability, NoMA has been identified as a promising technology to help achieve all the targets in system capacity, user connectivity, and service latency. This article will provide a systematic overview of the state-of-the-art design of the NoMA transmission based on a unified transceiver design framework, the related standardization progress, and some promising use cases in future cellular networks, based on which the interested researchers can get a quick start in this area.
ChemInform Abstract: Structure of Argifin, a New Chitinase Inhibitor Produced by Gliocladium sp. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Refractive and diffractive properties of planar micro-optical elements (1995)

The refractive and the diffractive properties of planar micro-optical elements are investigated. The transition between purely refractive and purely diffractive planar microlenses is numerically simulated for the example of differently designed phase-matched Fresnel elements. Results obtained from numerical simulations and experiments show that the refractive and diffractive types exhibit a distinctly different behavior in the presence of small fabrication errors or wavelength deviations. Based on these results, design rules for various applications, including low- and high-numerical-aperture lenses and hybrid refractive-diffractive elements, are derived. For a high-numerical-aperture (ƒ /# = 1.0) lens the experimental characterization of the irradiance distribution in the image space is presented and shown to agree well with theoretical predictions.
Switching characteristics of high power buried gate turn-off thyristor (1982)

Recently, high power gate turn-off thyristor (GTO) has received much attention as a new device in the power electronics field (1) (2) (3). The self turn-off capability of GTO provides an advantage over the conventional thyristor, because of forced commutation circuit removal upon inverter and chopper application, thus substantially reducing equipment size, weight, noise, and improving efficiency. We have successfuly developed the high power GTO's capable of 800A and 1200A current interruption. By introducing the buried gate structure, this device has a high gate-cathode reverse breakdown voltage. In addition, the amplifying gate is used to supply a large turn-on trigger current. This paper describes the switching characteristics of the buried gate GTO with amplifying gate structure. The requirements for the gate drive and snubber are also discussed.
Scene Analysis for Speech and Audio Recognition (2003)

Focuses on several different approaches to handling sound mixtures: computational auditory scene analysis, multicondition training, and parallel-model-based techniques such as HMM decomposition and multisource decoding.
Update on Catheter Ablation of Atrial Tachycardia, Atrial Flutter, and Beyond (1996)

Atrial tachyarrhythmias represent a great challenge to successful treatment, It is important to recall that atrial tachycardia may occur by one of several mechanisms. Because of their poor response to medical therapy, atrial tachycardias are increasingly being approached with transcatheter ablation.
Electromagnetic sensors from algebraic corner vortex generation in polygonal plates (2017)

We study rigorously the response of a finite polygonal plate to an external electromagnetic field at finite frequencies with our recent approach generalizing the conformal mapping idea to finite frequency electromagnetics. We find that vortices of an algebraic nature are generated at the corners. A way to measure these local vortices via an induced static voltage is proposed.
A novel ring expansion observed during the lithium aluminum hydride reduction of 13-nitrooxyberberine (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA novel ring expansion observed during the lithium aluminum hydride reduction of 13-nitrooxyberberineMark Cushman, Pennamuthiriar Chinnasamy, Donald A. Patrick, Ann T. McKenzie, and Pascal H. TomaCite this: J. Org. Chem. 1990, 55, 24, 5995–6000Publication Date (Print):November 1, 1990Publication History Published online1 May 2002Published inissue 1 November 1990https://pubs.acs.org/doi/10.1021/jo00311a018https://doi.org/10.1021/jo00311a018research-articleACS PublicationsRequest reuse permissionsArticle Views150Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Temperature Induced Voltage Offset Drifts in Silicon Carbide Pressure Sensors (2012)

We report the reduction of transient drifts in the zero pressure offset voltage in silicon carbide (SiC) pressure sensors when operating at 600 °C. The previously observed maximum drift of ± 10 mV of the reference offset voltage at 600 °C was reduced to within ± 5 mV. The offset voltage drifts and bridge resistance changes over time at test temperature are explained in terms of the microstructure and phase changes occurring within the contact metallization, as analyzed by Auger electron spectroscopy and field emission scanning electron microscopy. The results have helped to identify the upper temperature reliable operational limit of this particular metallization scheme to be 605 °C.
Uncovering the Rosetta Stone: Report from the First Annual Conference on Key Elements in Translating Stroke Therapeutics from Pre-Clinical to Clinical (2018)

The first annual Stroke Translational Research Advancement Workshop (STRAW), entitled "Uncovering the Rosetta Stone: Key Elements in Translating Stroke Therapeutics from Pre-Clinical to Clinical" was held at the University of Kentucky on October 4-5, 2017. This workshop was organized by the Center for Advanced Translational Stroke Science. The workshop consisted of 2 days of activities. These included three presentations establishing the areas of research in stroke therapeutics, discussing the routes for translation from bench to bedside, and identifying successes and failures in the field. On day 2, grant funding opportunities and goals for the National Institute for Neurological Diseases and Stroke were presented. In addition, the meeting also included break-out sessions designed to connect researchers in areas of stroke, and to foster potential collaborations. Finally, the meeting concluded with an open discussion among attendees led by a panel of experts.
Combinatorial Development of Pressure‐Sensitive Adhesives (2004)

Abstract Summary: Combinatorial libraries of pressure‐sensitive adhesives were prepared and characterized using a spherical probe tester. Force‐displacement profiles generated for each adhesive provided information related to tack, peel, and shear behavior. These data were used to find the best adhesive, which was then used to generate a combinatorial library of varying thickness. These data demonstrate the utility of high‐throughput screening in pressure‐sensitive‐adhesive development. Adhesive daughter plate arranged in 48‐spot array. magnified image Adhesive daughter plate arranged in 48‐spot array.
Key Extraction From General Nondiscrete Signals (2010)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> We address the problem of designing optimal schemes for the generation of secure cryptographic keys from continuous noisy data. We argue that, contrary to the discrete case, a universal fuzzy extractor does not exist. This implies that in the continuous case, key extraction schemes have to be designed for particular probability distributions. We extend the known definitions of the correctness and security properties of fuzzy extractors. Our definitions apply to continuous as well as discrete variables. We propose a generic construction for fuzzy extractors from noisy continuous sources, using independent partitions. The extra freedom in the choice of discretization, which does not exist in the discrete case, is advantageously used to give the extracted key a uniform distribution. We analyze the privacy properties of the scheme and the error probabilities in a one-dimensional toy model with simplified noise. Finally, we study the security implications of incomplete knowledge of the source's probability distribution <formula formulatype="inline"><tex Notation="TeX">${\BBP }$</tex></formula>. We derive a bound on the min-entropy of the extracted key under the worst-case assumption, where the attacker knows <formula formulatype="inline"> <tex Notation="TeX">${\BBP }$</tex></formula> exactly. </para>
Search for gravitational-wave bursts in the first year of the fifth LIGO science run (2009)

We present the results obtained from an all-sky search for gravitational-wave (GW) bursts in the 64--2000 Hz frequency range in data collected by the LIGO detectors during the first year (November 2005---November 2006) of their fifth science run. The total analyzed live time was 268.6 days. Multiple hierarchical data analysis methods were invoked in this search. The overall sensitivity expressed in terms of the root-sum-square (rss) strain amplitude ${h}_{\mathrm{rss}}$ for gravitational-wave bursts with various morphologies was in the range of $6\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}22}\text{ }\text{ }{\mathrm{Hz}}^{\ensuremath{-}1/2}$ to a $\mathrm{\text{few}}\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}21}\text{ }\text{ }{\mathrm{Hz}}^{\ensuremath{-}1/2}$. No GW signals were observed and a frequentist upper limit of 3.75 events per year on the rate of strong GW bursts was placed at the 90% confidence level. As in our previous searches, we also combined this rate limit with the detection efficiency for selected waveform morphologies to obtain event rate versus strength exclusion curves. In sensitivity, these exclusion curves are the most stringent to date.
Modulation of alpha5beta1 integrin functions by the phospholipid and cholesterol contents of cell membranes. (2000)

Several modifications of the alpha5beta1 integrin, which alter its intracellular and extracellular interaction with fibronectin and other proteins, have been reported. However, the significance of the lateral mobility of integrin molecules in the plasma membrane, as a regulator of their distribution and function, is poorly understood. We examined this problem by increasing the cholesterol content of plasma membranes, and consequently modifying the fluidity of membrane phospholipids, in rat fibroblasts. Under these conditions, the clustering of alpha5beta1 integrin molecules in focal adhesions, their adhesion to the cell-binding domain of fibronectin, and their association with the cytoskeletal protein talin were significantly enhanced as compared to control cells. However, the activation of MAP-kinase pathways by the association of fibronectin with alpha5beta1 integrin, and its association with integrin-linked kinase (ilk), were suppressed. The treated cells also showed distinct changes in shape, and their actin stress fiber network was more dense and thick as compared to control cells. The changes in fluidity of phospholipids occurred differentially and fluidity of phosphatidyl-ethanolamine increased, while that of phosphatidyl-choline was reduced. Our results suggest that proteins in focal adhesions could be partitioned in specific lipid domains, which regulate specific aspects of alpha5beta1 integrin functions.