gebhart/patrepeval huggingface dataset:
A Bayesian regression analysis of truck drivers’ use of cooperative adaptive cruise control (CACC) for platooning on California highways (2021)

Cooperative Adaptive Cruise Control (CACC), as an advanced version of adaptive cruise control (ACC), automates brake and engine controls based on the information received from wireless V2V communications and remote sensors, enabling smaller vehicle-following time gaps. It can improve the safety of vehicle platooning and increase fuel savings. As an extension of our previous investigation of truck drivers’ acceptance of CACC, this case study investigates factors affecting the use of CACC for truck platooning. Nine commercial fleet drivers were recruited to operate two following trucks in a CACC-enabled string on freeways in Northern California. We analyzed the usage of CACC time gaps and its correlation with truck drivers’ stated preferences for these time gaps, and we found that the highest preferred Gap 3 (1.2 s) was used the most. Moreover, a Bayesian regression model was built to show that truck drivers are more likely to disengage CACC when driving in low-speed traffic or on downgrades where this CACC could not provide sufficient braking. In high-speed traffic or on upgrades, truck drivers are more likely to engage CACC, particularly at Gap 3. Truck position, however, does not affect truck drivers’ time gap selection. The findings encourage the adoption of CACC in the trucking industry through implementing driver-preferred time gaps and responsive braking systems, and operating on routes with minimal interference to truck speeds.
Low modal volume dipole-like dielectric slab resonator (2008)

We propose a novel geometry in a silicon planar resonator with an ultra-small modal volume of 0.01(lambda/2n)(3). The geometry induces strong electric field discontinuities to decrease the modal volume of the cavity below 1(lambda/2n)(3) The proposed structure and other common resonators such as 1D and 2D photonic crystal resonators are compared for tradeoffs in confinement and quality factors.
Publisher’s Note: “Observation of columnar microstructure in lattice-matched InAlN/GaN grown by plasma assisted molecular beam epitaxy” [Appl. Phys. Lett. 100, 232102 (2012)] (2012)

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A Position-Based Clustering Technique for Ad Hoc Intervehicle Communication (2008)

Intervehicle communication is a key technique of intelligent transport systems. Ad hoc networking in the vehicular environment was investigated intensively. This paper proposes a new clustering technique for large multihop vehicular ad hoc networks. The cluster structure is determined by the geographic position of nodes and the priorities associated with the vehicle traffic information. Each cluster elects one node as its cluster head. The cluster size is controlled by a predefined maximum distance between a cluster head and its members. Clusters are independently controlled and dynamically reconfigured as nodes move. This paper presents the stability of the proposed cluster structure, and communication overhead for maintaining the structure and connectivity in an application context. The simulation is performed with comparative studies using CORSIM and NS-2 simulators.
An improved procedure for quantitating mitochondrial DNA in cultured mammalian cells. (1990)

A new improved method that reproducibly measures small perturbations of mitochondrial DNA in populations of cells has been developed. It is based on first obtaining a cell count and then analyzing three aliquots of cells: one for total DNA per cell by fluorometry, one for total protein per cell and one for the amount of mitochondrial DNA per microgram of total cell DNA. To quantitate mitochondrial DNA, 0, 1, 2, and 3 nanograms of mouse mtDNA purified from a plasmid are added as internal standard DNA to four 1.0-microgram samples of purified total cell DNA containing an unknown amount of mitochondrial DNA (a sample set). Three sample sets are electrophoresed in an agarose gel devoid of ethidium bromide. Following Southern transfer to nitrocellulose and hybridization to purified 32P-labeled mouse mitochondrial DNA, an autoradiogram is prepared for use as a template to locate the mitochondrial DNA bands. These bands are cut out of the nitrocellulose filters, and their 32P-content is determined using a liquid scintillation counter. For each sample set, the counts per minute is plotted against the amount of mitochondrial DNA added. The plot is linear and the negative average of the values for the three intercepts on the x-axis yields the amount of nanograms of mitochondrial DNA per microgram of total cell DNA. The method is highly reproducible with a standard deviation of approximately 9 percent. The advantages of using this method over others that have been reported are discussed.
Tracking genome-editing and associated molecular perturbations by SWATH mass spectrometry (2019)

Advances in gene editing now allow reverse genetics to be applied to a broad range of biological systems. Ultimately, any modification to coding sequences requires confirmation at the protein level, although immunoblotting is often hampered by antibody quality or availability especially in non-model species. Sequential Window Acquisition of All Theoretical Spectra (SWATH), a mass spectrometry (MS) technology with exceptional quantitative reproducibility and accuracy, offers an ideal alternative for protein-based confirmation. Here, using genome edits in mouse, zebrafish and Bicyclus anynana butterflies produced using either homologous recombination or targeted nucleases, we demonstrate absence of the targeted proteins using SWATH, thus confirming successful editing. We show that SWATH is a robust antibody-independent alternative for monitoring gene editing at the protein level and broadly applicable across diverse organisms and targeted genome manipulation techniques. Moreover, SWATH concomitantly defines the global proteome response in the edited organism, which may provide pertinent biological insights.
Cryptographic key generation from voice (2002)

We propose a technique to reliably generate a cryptographic key from a user's voice while speaking a password. The key resists cryptanalysis even against an attacker who captures all system information related to generating or verifying the cryptographic key. Moreover, the technique is sufficiently robust to enable the user to reliably regenerate the key by uttering her password again. We describe an empirical evaluation of this technique using 250 utterances recorded from 50 users.
A 500 MHz, 68% efficient, fully on-die digitally controlled buck Voltage Regulator on 22nm Tri-Gate CMOS (2014)

A fully on-die, digitally controlled, 500MHz switching, 250mA rated output buck Voltage Regulator (VR) implemented in 22nm Tri-Gate CMOS is presented. The silicon measured a peak efficiency of 68% and consumed an area of 0.6mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> (without output decoupling) with a power density of about 410 mW/mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The paper also demonstrates a controller bandwidth of 43MHz; the highest reported to date for any digital controller, resulting in output voltage ramp rates as high as 10V/µsec.
Degraded multicasting with network coding over the combination network (2011)

In this paper, we give a characterization of the rate region for the degraded two message set problem, applied to a combination network with erasure channels. We also provide an algorithm that uses topological information in order to deliver the two messages to the receivers, and we show that our algorithm is optimal, in the sense that it achieves any rate pair in the region. We compare our algorithm analytically with a naive approach oblivious to the network structure, and we give an insight on what benefits should be expected for different classes of networks.
Non-redundant functionality of Lactiplantibacillus plantarum phospho-β-glucosidases revealed by carbohydrate utilization signatures associated to pbg2 and pbg4 gene mutants (2023)

Lactiplantibacillus plantarum gene mutants that lack individual 6-phospho-β-glucosidases display very different carbohydrate utilization signatures showing that these enzymes can be crucial to determine the capacity of L. plantarum to consume different C-sources and hence for the nutrition and physiology of this microorganism.
Pressure Amplitude Influence on Pulsating Exhaust Flow Energy Utilization (2018)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;A turbocharged Diesel engine for heavy-duty on-road vehicle applications employs a compact exhaust manifold to satisfy transient torque and packaging requirements. The small exhaust manifold volume increases the unsteadiness of the flow to the turbine. The turbine therefore operates over a wider flow range, which is not optimal as radial turbines have narrow peak efficiency zone. This lower efficiency is compensated to some extent by the higher energy content of the unsteady exhaust flow compared to steady flow conditions. This paper experimentally investigates the relationship between exhaust energy utilization and available energy at the turbine inlet at different degrees of unsteady flow. A special exhaust manifold has been constructed which enables the internal volume of the manifold to be increased. The larger volume reduces the exhaust pulse amplitude and brings the operating condition for the turbine closer to steady-flow. The operating points are defined by engine speed and boost pressure. From these values the isentropic turbine work is calculated and with the measured compressor work the mean turbine efficiency is estimated. The results show that more energy has to be provided to the turbine at larger exhaust manifold volumes to maintain a constant boost pressure, indicating that the efficiency of the turbine decreases.&lt;/div&gt;&lt;/div&gt;
Nanodome sensor tubing for monitoring of intravenous drug infusion and metabolites (2011)

Continuous monitoring of fluids in medical tubing is desired for point-of-care clinical diagnostics. In this work, we incorporate a nanostructured surface-enhanced Raman scattering (SERS) sensor into flexible tubing commonly used for intravenous drug delivery and urinary catheters. We investigate the detection of promethazine (pain medication) and urea (common metabolite found in urine) as model systems for continuous in-line monitoring.
Electronic Properties and Supramolecular Organization of Terminal Bis(alkylethynyl)-Substituted Benzodithiophenes (2010)

Benzodithiophene (BDT) was symmetrically bisubstituted in the terminal positions with five different alkynes C≡C-(C(n)H(2n+1)) with n = 4, 6, 8, 10, 12. The materials were characterized as potential materials for field-effect transistor applications. Electrochemical measurements in solution and photophysical measurements in solution and in the solid state, together with UV photoelectron spectroscopy in air and quantum-chemical calculations, elucidate the nature of the frontier orbitals and of the excited states as well as their deactivation pathways. Structural information on the molecular assembly in the solid state, both at room temperature and at elevated temperatures, is obtained by a combination of DSC, polarized optical microscopy, and 2D-WAXS, which point to the crystallinity of the compounds in all phases and reveal π-stacking arrangements independently of the length of the alkyl side chains.
SHELF‐LIFE OF FRIED POTATO CHIPS USING RBD PALM OLEIN, SOYBEAN OIL AND THEIR BLENDS (1999)

ABSTRACT Shelf‐life of potato chips fried in refined, bleached and deodorized palm olein (RBDPO), soybean oil (SBO) and their blends was evaluated. Potato slices were fried for 130 s at 180 PT 5C at 30 min intervals over a period of 5 h/day for 5 consecutive days. Indicators of frying oil quality with the shelf‐life of fried products chosen were total polar component and acid value. This study indicated that RBDPO was better than SBO for the preparation of fried potato chips in terms of shelf‐life of products. The blends were also slightly better than SBO with increasing proportion of RBDPO. However, the effects were minimal on the rate of development of rancidity in fried products beyond the fourth day of frying in the frying medium.
Shape from focus system (2003)

A shape-from-focus method that uses different focus levels to obtain a sequence of object images is described. A sum-modified-Laplacian operator is developed to provide local measures of the quality of image focus. The operator is applied to the sequence of images of the object to determine a set of focus measures as each image point. A model is developed to describe the variation of focus measure values due to defocusing. This model is used by a depth estimation algorithm to interpolate focus measure values and obtain accurate depth estimates. A fully automated system that has been implemented using an optical microscope and tested on a variety of industrial samples is described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Affinity Maturation to Improve Human Monoclonal Antibody Neutralization Potency and Breadth against Hepatitis C Virus (2011)

A potent neutralizing antibody to a conserved hepatitis C virus (HCV) epitope might overcome its extreme variability, allowing immunotherapy. The human monoclonal antibody HC-1 recognizes a conformational epitope on the HCV E2 glycoprotein. Previous studies showed that HC-1 neutralizes most HCV genotypes but has modest potency. To improve neutralization, we affinity-matured HC-1 by constructing a library of yeast-displayed HC-1 single chain Fv (scFv) mutants, using for selection an E2 antigen from one of the poorly neutralized HCVpp. We developed an approach by parallel mutagenesis of the heavy chain variable (VH) and κ-chain variable (Vk) genes separately, then combining the optimized VH and Vk mutants. This resulted in the generation of HC-1-related scFv variants exhibiting improved affinities. The best scFv variant had a 92-fold improved affinity. After conversion to IgG1, some of the antibodies exhibited a 30-fold improvement in neutralization activity. Both surface plasmon resonance and solution kinetic exclusion analysis showed that the increase in affinity was largely due to a lowering of the dissociation rate constant, Koff. Neutralization against a panel of HCV pseudoparticles and infectious 2a HCV virus improved with the affinity-matured IgG1 antibodies. Interestingly, some of these antibodies neutralized a viral isolate that was not neutralized by wild-type HC-1. Moreover, propagating 2a HCVcc under the selective pressure of WT HC-1 or affinity-matured HC-1 antibodies yielded no viral escape mutants and, with the affinity-matured IgG1, needed 100-fold less antibody to achieve complete virus elimination. Taken together, these findings suggest that affinity-matured HC-1 antibodies are excellent candidates for therapeutic development.
A phase 3 trial of fianlimab (anti–LAG-3) plus cemiplimab (anti–PD-1) versus pembrolizumab in patients with previously untreated unresectable locally advanced or metastatic melanoma. (2023)

TPS9602 Background: Fianlimab (anti-lymphocyte activation gene 3 [LAG-3]) and cemiplimab (anti- programmed cell death-1 [PD-1]) are both high-affinity, fully human, IgG4 monoclonal antibodies (Abs). Concurrent blockade of anti-LAG-3 and anti-PD-1 has shown enhanced efficacy (increase in progression free survival [PFS]) in advanced melanoma (Mel). We previously presented data from a phase 1 study showing a 63.8% objective response rate (ORR) across two separate cohorts of advanced PD-(L)1 naïve metastatic Mel patients (pts) treated with fianlimab plus cemiplimab with an acceptable risk-benefit profile. Methods: This is a randomized, double-blind, phase 3 study to evaluate fianlimab plus cemiplimab compared to pembrolizumab in pts with previously untreated unresectable locally advanced or metastatic Mel (NCT05352672). This study will be conducted globally, at approximately 200 sites. Key inclusion criteria are: (1) ≥12 years of age; (2) histologically confirmed unresectable Stage III and Stage IV (metastatic) Mel (3) no prior systemic therapy for advanced unresectable disease, prior (neo)adjuvant therapies are allowed with treatment/disease-free interval of 6 months; (4) measurable disease per Response Evaluation Criteria in Solid Tumors version 1.1; (5) valid LAG-3 results; (6) Eastern Cooperative Oncology Group performance status (PS) of 0 or 1 (for adult pts), Karnofsky PS ≥70 (pts ≥16 years) or Lansky PS ≥70 (pts &lt; 16 years); and (7) anticipated life expectancy of at least 3 months. There are 4 arms to the study: (1) Arm A: fianlimab (1600 mg) + cemiplimab (350 mg) every 3 weeks (Q3W), intravenously (IV); (2) Arm A1: fianlimab (400 mg) + cemiplimab (350 mg) Q3W, IV; (3) Arm B: pembrolizumab (200 mg Q3W, IV) + saline/dextrose placebo (placebo); (4) Arm C: cemiplimab (350 mg Q3W, IV) + placebo. The trial is expected to enroll approximately 1590 pts. The primary endpoint is progression-free survival. The key secondary endpoints are overall survival and objective response rate. The additional secondary endpoints include disease control rate, duration of response, safety, pharmacokinetics of cemiplimab and fianlimab, and immunogenicity (incidence and titer of anti-drug Abs and neutralizing Abs). The study is currently open for enrollment. Clinical trial information: NCT05352672 .
Ethylene oligomerization using iron complexes: beyond the discovery of bis(imino)pyridine ligands (2013)

Since the discovery that bis(imino)pyridine ligands are able to confer high activities in ethylene oligomerization and polymerization to their iron complexes, considerable attention has been focused on catalyst design for these reactions and this research constitutes an ever-growing area in molecular catalysis. The tuning of the ligand structures and properties, and thus of catalysts, generally represents the basis for subsequent work contributing to process development and industrialization. Significant effort is therefore devoted to generate structural diversity in order to access the required catalyst stability and selectivity. This feature article outlines nitrogen-containing ligands that have been developed for the iron-catalyzed oligomerization of ethylene since the seminal discovery of the properties of bis(imino)pyridine ligands.
A PHASE CHANGE MICROVALVE USING A MELTABLE MAGNETIC MATERIAL: FERRO-WAX (2005)

This paper presents a novel phase change microvalve using a paraffin-based ferrofluid plug (called “Ferro-Wax”). The Ferro-Wax plug is essentially leak-proof because of the phase change nature of the material; once the plug is solidified, it forms a solid seal. The meltable magnetic plug changes the phase from solid to liquid by an on-chip heating and moves remotely in a channel by a magnetic actuation. The reversible microvalve performed excellently up to 50 psi. The ease of fabrication and integration makes this microvalve invaluable for a next generation lab-on-a-chip device for on-chip sample preparation and label-free detection, which is currently underway.
A literatura oral no ensino da língua portuguesa (2016)

With this article we intend to draw attention to a very specific aspect of English language programs. We reflect on the ideological, ethical and aesthetic reasons which have guided the inclusion of the Portuguese oral tradition texts (and not only) in the manuals of Portuguese primary and secondary schools from different eras. We will focus on the Portuguese case, but the conclusions reached are applicable essentially to Portuguese-speaking countries.
Electromagnetic Analysis of the RFID Link (2008)

The recent widespread diffusion of radio-frequency&#13;\nidentification (RFID) applications operating in the UHF band&#13;\nhas been supported by both the request for greater&#13;\ninterrogation ranges and greater and faster data exchange.&#13;\nUHF-RFID systems, exploiting a physical interaction based on&#13;\nElectromagnetic propagation, introduce many problems that&#13;\nhave not been explored (or only partially) for the previous&#13;\ngenerations of RFID systems (e.g. HF). Therefore, the&#13;\navailability of reliable tools for modeling and evaluating the&#13;\nradio-communication between Reader and Tag within an&#13;\nRFID radio-link are needed. The paper discuss the impact of&#13;\nreal environment (e.g. Electromagnetic Coupling, Multipath&#13;\npropagation) on system performance in terms of errorprobability&#13;\nand received powers, showing some rel
Noggin haploinsufficiency influences severity of arthritis in different mouse models (2005)

Chaperonins have classically been thought of as intracellular molecules involved in the correct folding of proteins. Their expression is upregulated during times of stress such as heat (hence their common nomenclature as heat shock proteins [HSP]), anoxia, hypoglycaemia and reactive oxygen species [1]. These are conditions found in infected tissues or in tissues with chronic inflammation such as the rheumatoid synovium. In their intracellular location they protect the cell from apoptotic death due to stress. Increasingly chaperonins have been recognised to subserve extracellular functions for which they have received the name 'chaperokines' since they bind to specific receptors on the cell surface and activate cells of the innate immune system to secrete inflammatory cytokines, chemokines and small molecular weight mediators such as prostaglandins [2]. Indeed, an early event in inflammation is cell stress/necrosis leading to the release of HSP60 and HSP70 that binds via a CD14-mediated mechanism to Toll-like receptors 2 and 4 [2] as part of the 'danger' signal [3]. The secretion of tumour necrosis factor alpha, IL-1, IL-12 and other chemokines prepares the environment for a TH1 adaptive immune response. It is now recognised that some chaperonins, such as BiP and HSP27, may activate the innate immune system to secrete anti-inflammatory cytokines, such as IL-10 [4,5] that may skew the adaptive immune response to TH2. Recent work by our group has shown that BiP can not only prevent but also treat ongoing collagen-induced arthritis in DBA/1 mice [6], suggesting that chaperonins may down modulate ongoing TH1 responses. Thus, it may be possible to suppress rheumatoid inflammation by administration of appropriate chaperonins such as BiP. Finally, chaperonins may be important system regulators determining the outcome between TH1 and Th2 immune responses. References 1.
Table S2 from Enrichment of PI3K-AKT–mTOR Pathway Activation in Hepatic Metastases from Breast Cancer (2023)

&lt;p&gt;Proportion of patients with mutation/activation of the PIK3CA-AKT-mTOR pathway in liver metastases compared to other organ sites and primary tumors of the breast.&lt;/p&gt;
Association of anti-idiotypic antibodies with immune tolerance induction for the treatment of hemophilia A with inhibitors. (2004)

Our results suggest that; (i) plasma from patients in whom ITI was completely successful contained an anti-FVIII antibody-neutralization factor; (ii) the anti-FVIII antibody-neutralization factor was in the IgG fraction (i.e., the factor would be anti-idiotypic antibodies), and (iii) anti-idiotypic antibodies existed even in plasma from patients in whom ITI was unsuccessful. Our observations support the notion that the mechanism of ITI is associated with the development of anti-idiotypic antibodies.
Low-frequency noise characteristics of channel substrate planar GaAlAs laser diodes (1981)

The influence of external feedback on low-frequency noise generation (100 Hz–10 kHz) in single longitudinal and transverse mode channel substrate planar laser diodes is reported. An increase in noise by as much as 60 dB was induced by external feedback as small as 0.04%. The induced intensity variations were observed to be sensitive to both phase and amplitude of the externally reflected light.
Increased sensitivity of Love wave delay-lines for polyelectrolyte multilayers through the deposition of a mesoporous TiO2 coating (2010)

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