gebhart/patrepeval huggingface dataset:
Abstract LB-279: N-cadherin promotes castration-resistant prostate cancer progression by enhancing stem cell properties of prostate cancer cells (2016)

Abstract New generation of anti-androgen treatments such as enzalutamide and abiraterone are improving survival of men with advanced and metastatic prostate cancers, but resistance to these inevitably arises. The molecular mechanisms governing the emergence of treatment resistance in castration resistant prostate cancer (CRPC) patients are not well understood. Recent experience suggests that tumor regeneration from castration-resistant stem-like cells induce resistance to hormonal therapy. Therefore, elucidating novel targets essential for driving stem-like activity is critical to prevent and defeat CRPC. It has been shown that normal and cancer stem cells exploit normal development process of epithelial-mesenchymal transition (EMT) to survive and metastasize, and that EMT confer stem cell properties to more differentiated cancer cell progeny in breast and other cancers. However, it is unclear if EMT is linked with stem cells in normal and malignant prostate. We previously showed that N-cadherin, a marker of EMT, promotes CRPC progression and that there was a correlation between N-cadherin expression and the expression of stem cell associated markers. This leads to hypothesis that N-cadherin may promote CRPC by enhancing tumorige esis/tumor initiating properties of cancer cells in a castrate environment. N-cadherin may confer tumor initiating or stem-like properties to prostate cancer cells perhaps uniquely or specific to in a castrate environment. Here, we verified that EMT is linked to stem cells in both normal prostate and CRPC. We further demonstrate that N-cadherin is involved in increased stem cell properties in normal mouse and human prostates from clinical samples in an androgen-deprived environment. Castration elevates the expression of N-cadherin and stem cell marker Trop2, accompanied with enhanced stem cell properties of luminal population in normal mouse prostates. N-cadherin upregulates stem cell properties in prostate cancer cells in the absence of androgen and CRPC tumors. N-cadherin-positive cells from CRPC tumors behave as stem cells. Overexpression of N-cadherin enhances ALDH activity in a panel of prostate cancer cell lines. Our findings reveal an important role of N-cadherin in prostate cancer and stem cells, and provide useful information of EMT-related biomarkers for preventing and developing efficient therapeutics to combat the treatment resistance to next-generation AR antagonists. Citation Format: Shu Lin, Tanya Stonyanova, Evelyn Kono, Jaclyn Matsuura, Naoko Kobayashi, Joyce Yamashiro, Dai Hong, Owen N. Witte, Andrew S. Goldstein, Robert E. Reiter. N-cadherin promotes castration-resistant prostate cancer progression by enhancing stem cell properties of prostate cancer cells. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr LB-279.
Multiple metal-carbon bonds. 5. The reaction of niobium and tantalum neopentylidene complexes with the carbonyl function (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple metal-carbon bonds. 5. The reaction of niobium and tantalum neopentylidene complexes with the carbonyl functionRichard R. SchrockCite this: J. Am. Chem. Soc. 1976, 98, 17, 5399–5400Publication Date (Print):August 1, 1976Publication History Published online1 May 2002Published inissue 1 August 1976https://pubs.acs.org/doi/10.1021/ja00433a062https://doi.org/10.1021/ja00433a062research-articleACS PublicationsRequest reuse permissionsArticle Views878Altmetric-Citations139LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Structural Properties of ZnO Grown on GaN∕Sapphire Templates (2007)

10.1149/1.2428413
(Invited) Dielectric Damage (2014)

More and more high- and low-k dielectrics are used in microfabrication today. However, as is well known, these materials are easily damaged during processing or during operation in a device. Sources of damage include plasma and/or VUV exposure, water uptake, free radicals as well as cosmic rays. A description of the damage effects on dielectrics from water uptake, plasma and/or VUV exposure, and neutron exposure is presented. Although the results for neutron exposure are presented for a high-k dielectric, HfO 2 , they can easily be extended to low-k dielectrics.
Redefining a Contribution for Immersive Visualization Research (2016)

Immersive computing modalities such as AR, VR, and speech-based input are regaining prominence as research threads in the visualization field due to the advancement in technology and availability of cheap consumer hardware. This renewed interest is similar to what we observed a decade ago when multitouch technology was gaining mainstream adoption. In this work, we reflect on lessons learned from designing for multitouch, with the goal of highlighting problems that may also emerge in AR/VR research. Specifically, we emphasize the need for the field to rearticulate what is expected from research efforts in the area of visualization on immersive technologies.
Microfabricated Engineered Particle Systems for Respiratory Drug Delivery and Other Pharmaceutical Applications (2012)

Particle Replication in Non-Wetting Templates (PRINT(®)) is a platform particle drug delivery technology that coopts the precision and nanoscale spatial resolution inherently afforded by lithographic techniques derived from the microelectronics industry to produce precisely engineered particles. We describe the utility of PRINT technology as a strategy for formulation and delivery of small molecule and biologic therapeutics, highlighting previous studies where particle size, shape, and chemistry have been used to enhance systemic particle distribution properties. In addition, we introduce the application of PRINT technology towards respiratory drug delivery, a particular interest due to the pharmaceutical need for increased control over dry powder characteristics to improve drug delivery and therapeutic indices. To this end, we have produced dry powder particles with micro- and nanoscale geometric features and composed of small molecule and protein therapeutics. Aerosols generated from these particles show attractive properties for efficient pulmonary delivery and differential respiratory deposition characteristics based on particle geometry. This work highlights the advantages of adopting proven microfabrication techniques in achieving unprecedented control over particle geometric design for drug delivery.
SiC On Insulator as substrate for power Schottky diodes (2002)

International audience
Alignment, Electronic Properties, Doping, and On-Chip Growth of Colloidal PbSe Nanowires (2007)

Single-crystalline straight, zigzag, helical, and branched nanowires can be synthesized by oriented attachment of PbSe nanocrystals followed by their fusion in the presence of different surfactants. These colloidal nanowires can be aligned in external electrical fields, facilitating their integration into electronic circuits. We show how the nanowire morphology affects the interaction of nanowires with the electric field. Conducting PbSe nanowires can be assembled from nanocrystal building blocks directly on a chip, growing along the electric field. As-formed PbSe nanowires show a p-type conduction that can be switched to an n-type by charge-transfer doping of the nanowires with hydrazine. In this work, we demonstrate strategies for device integration of solution-phase synthesized semiconductor nanowires and explore their electronic properties.
Is oxygen a key factor in the lipodystrophy phenotype? (2006)

Toxicity of NRTIs have been shown to be opposite on human adipose cells depending on the oxygen availability. These data suggest that the LD phenotype may be a differential consequence of NRTI effects, depending on the metabolic status of the targeted adipose tissues and provide new insights into the opposite effects of antiretroviral treatment, as observed for the lipo-atrophic and lipo-hypertrophic phenotype characteristic of LD.
Aβ oligomer concentration in mouse and human brain and its drug-induced reduction ex vivo (2022)

The elimination of amyloid beta (Aβ) oligomers is a promising strategy for therapeutic drug development of Alzheimer's disease (AD). AD mouse models that develop Aβ pathology have been used to demonstrate in vivo efficacy of compounds that later failed in clinical development. Here, we analyze the concentration and size distribution of Aβ oligomers in different transgenic mouse models of AD and in human brain samples by surface-based fluorescence intensity distribution analysis (sFIDA), a highly sensitive method for detecting and quantitating protein aggregates. We demonstrate dose- and time-dependent oligomer elimination by the compound RD2 in mouse and human AD brain homogenates as sources of native Aβ oligomers. Such ex vivo target engagement analyses with mouse- and human-brain-derived oligomers have the potential to enhance the translational value from pre-clinical proof-of-concept studies to clinical trials.
A Knowledge-Based Approach to Automated Interpretation of Performance (1992)

Models used to evaluate the performance of complex time-critical computer systems can produce voluminous amounts of data. This paper discusses the integration of knowledge-based systems with performance models to produce knowledge-based petformance evaluation systems that provide automated interpretation of model results. A three stage conceptual model of interpretation is developed. Design alternalives for developing knowledgebased performance evaluation systems are explored. The critical dependencies among automated interpretation, design representation, and performance models are described, and a threshold-based strategy for problem identification using the notion of causal factoring is discussed.
Halato-telechelic polymers. 8. Dependence of the viscoelastic behavior on the prepolymer molecular weight (1983)

peer reviewed
Mehrfachbindungen zwischen Übergangsmetallen und “nackten” Hauptgruppenelementen: Brücken zwischen der anorganischen Festkörperchemie und der Organometallchemie (1986)

Abstract Die Chemie der Metall‐Metall‐Mehrfachbindung hat in den vergangenen beiden Jahrzehnten eine stürmische Entwicklung erlebt, wobei insbesondere die Organometallchemie große Erfolge zu verzeichnen hatte. Die Entwicklung zielgerichteter Synthesen neuer Übergangsmetallkomplexe mit Einfach‐, Doppel‐, Dreifach‐ und Vierfachbindungen zwischen den Metallatomen sowie die Untersuchung von deren Reaktivität sind derzeit prominente Arbeitsgebiete. Die Hoffnung auf Verallgemeinerungs‐ und Ordnungsprinzipien ist eine Triebfeder dieser Aktivitäten, doch darf auch das weitergesteckte Ziel, Metall‐Metall‐Mehrfachbindungssysteme als Katalysatoren zu nutzen, nicht aus dem Auge verloren werden. Alle Aspekte, unter denen man bisher Metall‐Metall‐Mehrfachbindungen untersucht und beurteilt hat, interessieren auch bei der Verbindungsklasse, die bisher ein Schattendasein geführt hat: Komplexverbindungen mit Mehrfachbindungen zwischen Übergangsmetallatomen und substituentenfreien (“nackten”) Hauptgruppenelementatomen. Ursprünglich Zufallsentdeckungen, lassen die wenigen derzeit namhaft zu machenden Beispiele ausbaufähige Synthesekonzepte erkennen. Wenn, was zu erwarten ist, weitere Strukturtypen dieser Verbindungsklasse bekannt werden, dürfte dieser Zweig der präparativen Organometallchemie beispielsweise bei der Komplexstabilisierung und der Aktivierung kleiner Moleküle große Bedeutung erlangen. Um die Thematik umfassend zu beleuchten, wird die Komplexchemie nackter Kohlenstoff‐, Stickstoff‐ und Sauerstoffliganden hier nur soweit berücksichtigt, wie dadurch präparative und strukturchemische Beziehungen zu den Komplexverbindungen ihrer höheren Homologen sichtbar werden.
Microarray-Based Multiplexed Scanometric Immunoassay for Protein Cancer Markers Using Gold Nanoparticle Probes (2009)

We report the use of electroless gold deposition as a light scattering signal enhancer in a multiplexed, microarray-based scanometric immunoassay using gold nanoparticle probes. The use of gold development results in greater signal enhancement than the typical silver development, and multiple rounds of metal development were found to increase the resulting signal compared to one development. Using these conditions, the assay was capable of detecting 300 aM (approximately 9000 copies) of prostate specific antigen in buffer and 3 fM in 10% serum. Additionally, the highly selective detection of three protein cancer markers at low picomolar concentrations in buffer and 10% serum was demonstrated. The use of gold deposition may have significant utility in scanometric detection schemes and broader clinical and research applications.
Joint Channel and Mismatch Correction for OFDM Reception with Time-interleaved ADCs: Towards Mostly Digital MultiGigabit (2008)

Time-interleaved (TI) analog-to-digital converters (ADCs) are a promising architecture for realizing the high- speed ADCs required to implement mostly digital receivers for emerging multiGigabit communication systems. Mismatch between the parallel ADCs comprising a TI-ADC is a funda- mental performance bottleneck. While there exist mismatch cor- rection techniques for generic applications of ADC, we illustrate in this paper that mismatch compensation can be subsumed within the overall receiver design for communication applications. We consider an Orthogonal Frequency Division Multiplexing (OFDM) link with TI-ADC used after downconversion. We show that mismatch results in frequency selective interference across subcarriers that can significantly degrade the performance of a standard OFDM receiver. However, this performance degradation can be alleviated significantly by joint channel and mismatch esti- mation and compensation, leveraging already available training or pilot sequences. This eliminates the necessity for dedicated hardware for mismatch correction. Specifically, we present an algorithm for estimating the channel gains and the mismatch, followed by low-complexity linear equalization to suppress the inter-subcarrier interference resulting from the mismatch. Our simulations show that the error floor due to mismatch-generated interference can be eliminated, permitting bandwidth-efficient operation with large constellations.
Linear Multihop Amplify-and-Forward Relay Channels: Error Exponent and Optimal Number of Hops (2011)

We compute the random coding error exponent for linear multihop amplify-and-forward (AF) relay channels. Instead of considering only the achievable rate or the error probability as a performance measure separately, the error exponent results can give us insight into the fundamental tradeoff between the information rate and communication reliability in these channels. This measure enables us to determine what codeword length that is required to achieve a given level of communication reliability at a rate below the channel capacity. We first derive a general formula for the random coding exponent of general multihop AF relay channels. Then we present a closed-form expression of a tight upper bound on the random coding error exponent for the case of Rayleigh fading. From the exponent expression, the capacity of these channels is also deduced. The effect of the number of hops on the performance of linear multihop AF relay channels from the error exponent point of view is studied. As an application of the random coding error exponent analysis, we then find the optimal number of hops which maximizes the communication reliability (i.e., the random coding error exponent) for a given data rate. Numerical results verify our analysis, and show the tightness of the proposed bound.
Topology optimization of periodic microstructures with a penalization of highly localized buckling modes (2002)

Abstract The problem of determining highly localized buckling modes in perfectly periodic cellular microstructures of infinite extent is addressed. A double scale asymptotic technique is applied to the linearized stability problem for a periodic structure built from linearly elastic microstructures. The obtained stability condition for the microscale level is then used to establish a comparative analysis between different material distributions in the base cell subjected to the same strain field at the macroscale level. The idea is illustrated by some two‐dimensional finite element examples and used to design materials with optimal elastic properties that are less prone to localized instability in the form of local buckling modes at the scale of the microstructure. Copyright © 2002 John Wiley &amp; Sons, Ltd.
Fabrication of carbon/silica hybrid materials using cationic polymerization and the sol-gel process (2002)

Silica particles with different morphology have been functionalized with carbon shells by different synthetic procedures. In the key step, the bare silica particles are functionalized by a specific cationic surface polymerization with furfuryl alcohol (FA). The polyfurfuryl alcohol (PFA)/silica hybrid particles have been also post-functionalized with maleic anhydride (MSA) by a Diels Alder reaction. Simultaneously occuring cationic polymerization of FA and sol-gel process with TEOS has been used for producing interpenetrating carbon-silica hybrid materials. The thermal transformation of the PFA component on silica into the carbon phase has been carried out under argon atmosphere in a temperature range from 700°C to 900°C. The influence of the former morphology of the silica on the homogenity of the resulting carbon layer is shown by zetapotential measurements and electron microscopic investigations.
Basic Equations of Dynamic Elastic Stability for Thin-Walled Structural Members Subjected to Follower Loads and Their Application to Non-Conservative Torque Problems (1985)

The basic equations and the boundary conditions, in which the effect of an initial torsional moment M z 0 is included, and needed for the analysis of the dynamic elastic stability of thin-walled structural members subjected to follower loads are derived by introducing the concept of initial stress and using the principle of virtual work. The stability problems of columns with a channel section subjected to a non-conservative torque are investigated in terms of numerical examples.
Upregulation of ER Signaling as an Adaptive Mechanism of Cell Survival in HER2-Positive Breast Tumors Treated with Anti-HER2 Therapy (2015)

HER2 inhibition can enhance or restore ER expression with parallel Bcl2 upregulation, representing an ER-dependent survival mechanism potentially leading to anti-HER2 resistance.
Identification of Hypermethylated Genes Associated with Cisplatin Resistance in Human Cancers (2010)

Cisplatin is among the most widely used cytotoxic anticancer agents in solid tumors; however, the development of secondary resistance remains a major obstacle to clinical efficacy. Treatment-related DNA hypermethylation may play a role in creating drug-resistant phenotypes by inactivating genes that are required for cytotoxicity. We applied a pharmacologic unmasking approach to detect hypermethylated genes whose inactivation contributes to cisplatin resistance. Using three pairs of isogeneic, cisplatin-sensitive, and cisplatin-resistant cell lines derived from two parental cell lines (KB-3-1 and SCC25), we identified several hundred genes that were downregulated in each resistant cell line and reactivated by the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine. Among them, 30 genes were common to two or more cell lines and/or reported to be downregulated in previous studies. Bisulfite sequencing confirmed that 14 genes were hypermethylated in resistant cell lines but not in the sensitive parental cell lines. Six of 14 genes (SAT, C8orf4, LAMB3, TUBB, G0S2, and MCAM) were cisplatin inducible in sensitive but not in resistant cell lines. Small interfering RNA knockdown of two genes, SAT and S100P, increased cell viability with cisplatin treatment in sensitive parental cell lines. S100P knockdown significantly decreased the S-phase fraction of parental sensitive cell lines and slowed cell proliferation, which was associated with decreased sensitivity to cisplatin. Based on these findings, we conclude that DNA methylation is a frequent event in cells that are chronically exposed to cisplatin and that methylation-induced gene silencing may play a role in the development of resistance to cytotoxic chemotherapeutic agents.
Dizziness Handicap After Cartilage Cap Occlusion for Superior Semicircular Canal Dehiscence (2012)

Change in DHI score is variable. As described by DHI score, patients with higher preoperative handicap may demonstrate significant improvement after surgery, whereas those with mild handicap may not. These results are similar to previous reports and indicate that the cartilage cap occlusion technique may provide an alternative to middle fossa craniotomy approach for surgical management of symptomatic SCD.