MP01-19 RECENT EPIDEMIOLOGICAL AND METABOLIC TRENDS IN STONE DISEASE: RISING HYPOCITRATURIA AND HYPEROXALURIA (2017)

You have accessJournal of UrologyStone Disease: Epidemiology & Evaluation I1 Apr 2017MP01-19 RECENT EPIDEMIOLOGICAL AND METABOLIC TRENDS IN STONE DISEASE: RISING HYPOCITRATURIA AND HYPEROXALURIA Ramy F. Youssef, Jeremy W. Martin, Khashayar Sakhaee, John Poindexter, Simone L. Vernez, Rahul Dutta, Charles D. Scales, Glenn M. Preminger, and Michael E. Lipkin Ramy F. YoussefRamy F. Youssef More articles by this author , Jeremy W. MartinJeremy W. Martin More articles by this author , Khashayar SakhaeeKhashayar Sakhaee More articles by this author , John PoindexterJohn Poindexter More articles by this author , Simone L. VernezSimone L. Vernez More articles by this author , Rahul DuttaRahul Dutta More articles by this author , Charles D. ScalesCharles D. Scales More articles by this author , Glenn M. PremingerGlenn M. Preminger More articles by this author , and Michael E. LipkinMichael E. Lipkin More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.094AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Metabolic factors underlying the recent increase in stone prevalence are unknown. Herein, we evaluate metabolic risk factors in stone patients from two different decades, comparing changes in metabolic profiles of stone formers over time. METHODS A retrospective review was performed of patients who underwent metabolic evaluation of urolithiasis with 24-hour urine collections at a single institution. There were 309 stone patients evaluated from 1988-1994 (group 1), and 229 patients from 2007-2010 (group 2). A comparison between both groups was performed to assess changes in demographics and metabolic profiles. RESULTS Comparing group 1 to group 2, the male: female ratio decreased from 1.3:1 to 0.8:1, obese patients (BMI ≥ 30) increased from 22% to 35%, and patients ≥ 50 y increased from 29% to 47% (all p < .005). A greater percentage of patients had hypocitraturia in the recent cohort (46% to 60%, p = .001), with hypocitraturia significantly more frequent in obese patients (p = .005). Hyperoxaluria was also increased in group 2 compared to group 1 (23% to 30% p = .07), a finding that was significant in males (32% to 53%, p = .001). CONCLUSIONS Urolithiasis has increased in females, obese, and older patients, consistent with population based studies. We report a rising incidence of hypocitraturia and hyperoxaluria in the contemporary cohort, particularly in obese patients and in males, respectively. Further studies are needed to better characterize the metabolic changes corresponding to the increase in stone disease. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e8 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Ramy F. Youssef More articles by this author Jeremy W. Martin More articles by this author Khashayar Sakhaee More articles by this author John Poindexter More articles by this author Simone L. Vernez More articles by this author Rahul Dutta More articles by this author Charles D. Scales More articles by this author Glenn M. Preminger More articles by this author Michael E. Lipkin More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...