gebhart/patrepeval huggingface dataset:
Insulin Infusion Set Use: European Perspectives and Recommendations (2016)

Insulin pump users worldwide depend on insulin infusion sets (IISs) for predictable delivery of insulin to the subcutaneous tissue. Yet emerging data indicates that IISs are associated with many pump-related adverse events and may contribute to potentially life-threatening problem of unexplained hyperglycemia. The relative scarcity of published research on IISs to date, the heterogeneity of regional IIS practices, and the increasing demand for international standards guiding their use prompted convening of a panel of diabetologists and diabetes nurse educators last February, in Milan, Italy, to discuss a framework for optimizing IIS practice in Europe. The multinational panel was tasked, first, with identifying the often-overlooked IIS issues that can affect patients' experience of pump therapy-e.g., partial or complete blockage of the cannula, skin pathologies, unpredictable variations in insulin absorption, dislodgment, and the demands of site rotation and set changes-and, second, with establishing direction for developing cohesive protocols to assure long-term success. As reported in this article, the panel examined IIS-related complications of pump therapy encountered in clinical practice, considered country-wide policies to prevent and mitigate such complications, and updated priorities for improving IIS education on issues of device selection, skin care, and troubleshooting unexplained hyperglycemia. These recommendations may be more relevant with the possibility of closed-loop systems available in the near future.
Efficient AES implementations for ARM based platforms (2004)

The Advanced Encryption Standard (AES) contest, started by the U.S. National Institute of Standards and Technology (NIST), saw the Rijndael [13] algorithm as its winner [11]. Although the AES is fully defined in terms of functionality, it requires best exploitation of architectural parameters in order to reach the optimum performance on specific architectures. Our work concentrates on ARM cores [1] widely used in the embedded industry. Most promising implementation choices for the common ARM Instruction Set Architecture (ISA) are identified, and a new implementation for the linear mixing layer is proposed. The performance improvement over current implementations is demonstrated by a case study on the Intel StrongARM SA-1110 Microprocessor [2]. Further improvements based on exploitation of memory hierarchies are also described, and the corresponding performance figures are presented.
Photonic Ising Spin-Glass via Chip-Based Degenerate Kerr Oscillators (2020)

We demonstrate reconfigurable all-optical coupling between two degenerate optical parametric oscillators in silicon-nitride microresonators. We show in-phase and out-of-phase operation which is achieved at a fast regeneration rate of 400 kHz with a large phase tolerance.
Purification and Characterization of a Novel (S)-Enantioselective Transaminase fromPseudomonas fluorescensKNK08-18 for the Synthesis of Optically Active Amines (2011)

Pseudomonas fluorescens KNK08-18, showing (S)-selective transaminase activity, was isolated from soil by an enrichment culture method using (S)-7-methoxy-2-aminotetraline as the main nitrogen source. A transaminase was purified from the strain to homogeneity in seven steps. The relative mass of the enzyme was estimated to be 53 kDa on SDS-polyacrylamide gel electrophoresis and 120 kDa by gel filtration, suggesting a homodimeric structure. The optimal pH and temperature for enzyme activity were about 8.0–8.5 and 40 °C. The purified enzyme produced (S)-7-methoxy-2-aminotetraline, (S)-SMA, from 7-methoxy-2-tetralone (SMT) with high enantioselectivity. Although (S)-1-phenylethylamine was the best amino donor, β-alanine and 4-aminobutyric acid, which are good substrates for typical ω-amino acid transaminase (EC 2.6.1.18) and GABA transaminase (2.6.1.19), were not reacted. It aminated a broad range of carbonyl compounds containing aromatic, non-aromatic, and acidic and non-acidic substrates.
Supplementary Tables from Identification of Targetable FGFR Gene Fusions in Diverse Cancers (2023)

&lt;p&gt;Supplementary Tables - PDF file 753K, Supplementary Tables S1-S15 include transcriptome and exome sequencing results for the FGFR fusion positive index cases, and summaries of sequencing cohorts&lt;/p&gt;
AKT and MAPK signaling in KGF‐treated and UVB‐exposed human epidermal cells (2007)

Regulation of proliferation and differentiation in keratinocyte is a complex and dynamic process that involves activation of multiple signaling pathways triggered by different growth factors. Keratinocyte growth factor (KGF) is not only a potent mitogen, but differently from other growth factors, is a potent inducer of differentiation. The MAP kinase and AKT pathways are involved in proliferation and differentiation of many cell types including keratinocytes. We investigated here the role of KGF in modulating AKT and MAPK activity during differentiation of human keratinocytes. Our results show that the mechanisms of action of KGF are dose-dependent and that a sustained activation of the MAPK signaling cascade causes a negative regulation of AKT. We also demostrated increasing expression of KGFR substrates, such as PAK4 during keratinocyte differentiation parallel to the receptor upregulation.
Synthesizing Omnidirectional Antenna Patterns, Received Power and Path Loss from Directional Antennas for 5G Millimeter-Wave Communications (2014)

Omnidirectional path loss models are vital for radiosystem design in wireless communication systems, as they allow engineers to perform network simulations for systems with arbitrary antenna patterns. At millimeter-wave frequencies, channel measurements are frequently conducted using steerable highgain directional antennas at both the transmitter and receiver to make up for the significant increase in free space path loss at these frequencies compared to traditional cellular systems that operate at lower frequencies. The omnidirectional antenna pattern, and resulting omnidirectional received power must therefore be synthesized from many unique pointing angles, where the transmit and receive antennas are rotated over many different azimuth and elevation planes. In this paper, the equivalent omnidirectional antenna pattern and omnidirectional received power are synthesized by summing the received powers from all measured unique pointing angles obtained at antenna halfpower beamwidth step increments in the azimuth and elevation planes, and this method is validated by demonstrating that the synthesized omnidirectional received power and path loss are independent of antenna beamwidth, through theoretical analyses and millimeter-wave propagation measurements using antennas with different beamwidths. The method in this paper is shown to provide accurate results while enhancing the measurement range substantially through the use of directional antennas.
Erratum: Measurements of the Solar Neutrino Flux from Super-Kamiokande's First 300 Days [Phys. Rev. Lett. 81, 1158 (1998)] (1998)

Received 10 September 1998DOI:https://doi.org/10.1103/PhysRevLett.81.4279©1998 American Physical Society
Immunolabeling of Central Serotonin 5‐HT1Dβ Receptors in the Rat, Mouse, and Guinea Pig with a Specific Anti‐Peptide Antiserum (1995)

A synthetic peptide (25 amino acids) corresponding to a specific portion of the third intracytoplasmic loop of the rat serotonin 5-HT1B/1D beta receptor was coupled to keyhole limpet hemocyanin and injected monthly into rabbits. Anti-peptide antibodies were detected by enzyme-linked immunosorbent assay and characterized by immunoprecipitation of the 5-HT1B/1D beta receptor in CHAPS-solubilized extracts from rat striatal membranes. Up to 60% of solubilized striatal serotonin-O-carboxymethylglycyl[125I]iodotyrosinamide ([125I]GTI; a selective 5-HT1B/1D radioligand) binding sites were immunoprecipitated and subsequently pharmacologically identified as 5-HT1B receptors. The remaining 40% of [125I]GTI binding sites were shown to be 5-HT1D receptors. In addition, these antibodies were successfully used in immunofluorescence experiments to detect the 5-HT1B/1D beta, but not the 5-HT1D/1D alpha, receptor in transiently transfected LLC-PK1 cells. Immunoautoradiographic experiments performed with brain sections from the rat, mouse, and guinea pig showed that the substantia nigra and globus pallidus contained the highest densities of 5-HT1D beta receptor-like immunoreactivity. Comparison of the regional distribution of immunolabeling with that of the specific binding of [125I]GTI in the brain of these species further confirmed that the anti-peptide antibodies selectively recognized only the 5-HT1D beta component of [125I]GTI specific receptor binding sites.
Supplemental Tables 1 and 2, and Supplemental Figure Legends from Distinguishing Tumor from Associated Fibrosis to Increase Diagnostic Biopsy Yield with Polarization-Sensitive Optical Coherence Tomography (2023)

&lt;p&gt;Supplemental Tables 1 and 2, and Supplemental Figure Legends&lt;/p&gt;
Exploring the vulnerability of CMPs to soft errors with 3D stacked non-volatile memory (2011)

Spin-transfer Torque Random Access Memory (STT-RAM) emerges for on-chip memory in microprocessor architectures. Thanks to the magnetic field based storage STT-RAM cells have immunity to radiation induced soft errors that affect electrical charge based data storage, which is a major challenge in SRAM based caches in current microprocessors. In this study we explore the soft error resilience benefits and design trade offs of 3D-stacked STT-RAM for multi-core architectures. We use 3D stacking as an enabler for modular integration of STT-RAM caches with minimum disruption in the baseline processor design flow, while providing further interconnectivity and capacity advantages. We take an in-depth look at alternative replacement schemes in terms of performance, power, temperature, and reliability trade-offs to capture the multi-variable optimization challenges microprocessor architectures face. We analyze and compare the characteristics of STT-RAM, SRAM, and DRAM alternatives for various levels of the cache hierarchy in terms of reliability.
First-in-Class Anti-Cancer Nanoparticle Copper(Ii) Phosphorus Dendrimers as Pro-Apoptotic Bax Activators (2018)

This chapter traces the design and construction of original multivalent Copper-conjugated phosphorus dendrimers, their antiproliferative activities against various human cancer cell lines as well as their mode of action via Bax activation. The multivalent Cu-conjugated phosphorus dendrimers represent new and promising first-in-class anti-proliferative agents with an original mechanism of action in nanomedicine. The synthesis and the antitumor activities of the original copper-conjugated phosphorus dendrimers and corresponding monomers. Few anti-cancer small molecules and copper complexes were described as Bax activators. A major contributor for the opening of mitochondrial pores is Bax, a pro-apoptotic member of the Bcl2 protein family. Nanoparticles in general and dendrimers in particular showing potent anti-cancer activity through Bax activation pathway inducing apoptosis tumor cell death. Three different anti-cancer drug waves can be chronologically outlined as follows: conventional chemotherapeutics; anti-cancer drugs based on high molecular-targeting precision; and anticancer drugs targeting cellular multicomponent machineries and effector systems.
Dyser (2008)

The increasing penetration of the real world with embedded and globally networked sensors enables the formation of a Web of Things (WoT), where high-level state information derived from sensors is embedded into Web representations of real-world entities (e.g. places, objects, creatures). A key service for the WoT is searching for entities which exhibit a certain dynamic state at the time of the query, which is a challenging problem due to the dynamic nature of the sought state information and due to the potentially huge scale of the WoT. Below we report on our initial efforts to construct such a search engine and the underlying WoT.
Supplementary figure legends from NK-Cell Recruitment Is Necessary for Eradication of Peritoneal Carcinomatosis with an IL12-Expressing Maraba Virus Cellular Vaccine (2023)

&lt;p&gt;Supplementary figure legends&lt;/p&gt;
Hot-wire CVD hydrogenated amorphous silicon for multi-layer photonic applications (2020)

Amorphous silicon (a-Si) is considered as one of the potential materials for multi-layer photonics due its high refractive index, linear and non-linear optical properties. This makes a-Si integration compatible with the Silicon-on-Insulator (SOI) photonics by increasing circuit density at each optical device layer. However, the high absorption loss of a-Si would require hydrogenation to passivate the dangling bonds for low loss optical waveguide interconnects and coupling of light between optical layers. Without an efficient passivation process, optical loss per layer would be too high for a viable multi-layer photonic platform. Therefore, we have developed a low temperature process hydrogenated a-Si (a- Si:H) with Hot-Wire Chemical Vapour Deposition (HWCVD) method that is compatible with back-end-of-the-line (BEOL) integration with active photonic or electronic layers. This work describes the experimental control of deposition temperature to achieve low loss a-Si:H waveguiding layer and the inter-layer waveguide coupling structures. Our latest results show a-Si:H deposited at 230 <sup>o</sup>C has the lowest propagation loss of 0.7 dB/cm for a sub-micron ridge waveguide at 1550 nm wavelength and 45 dB cross-talk isolation between two waveguides separated by 1 μm of SiO<sub>2</sub> layer.
Synthesis and characterization of polypyrrole-hyaluronic acid composite biomaterials for tissue engineering applications (2000)

New tissue engineering technologies will rely on biomaterials that physically support tissue growth and stimulate specific cell functions. The goal of this study was to create a biomaterial that combines inherent biological properties which can specifically trigger desired cellular responses (e.g., angiogenesis) with electrical properties which have been shown to improve the regeneration of several tissues including bone and nerve. To this end, composites of the biologically active polysaccharide hyaluronic acid (HA) and the electrically conducting polymer polypyrrole (PP) were synthesized and characterized. Electrical conductivity of the composite biomaterial (PP/HA) was measured by a four-point probe technique, scanning electron microscopy was used to characterize surface topography, X-ray photoelectron spectroscopy and reflectance infrared spectroscopy were used to evaluate surface and bulk chemistry, and an assay with biotinylated hyaluronic acid binding protein was used to determine surface HA content. PP/HA materials were also evaluated for in vitro cell compatibility and tissue response in rats. Smooth, conductive, HA-containing PP films were produced; these films retained HA on their surfaces for several days in vitro and promoted vascularization in vivo. PP/HA composite biomaterials are promising candidates for tissue engineering and wound-healing applications that may benefit from both electrical stimulation and enhanced vascularization.
Supplementary Figure S1 from Molecular Drivers of the Non–T-cell-Inflamed Tumor Microenvironment in Urothelial Bladder Cancer (2023)

&lt;p&gt;Correlative plots depicting the relationship between expression of CCL4 and BATF3 with CD8A, WNT7B, and PPARG&lt;/p&gt;
#4261 RELATIONSHIP BETWEEN FLUID OVERLOAD AND AVERAGE PLASMA REFILL RATE IN HEMODIALYSIS PATIENTS (2023)

Abstract Background and Aims Attaining the optimal balance between achieving adequate volume removal while preserving organ perfusion remains challenging in patients on maintenance hemodialysis (HD). Quantification of fluid status using bioimpedance spectroscopy (BIS) has become routine in many countries. Inadequate vascular space refill from the interstitial tissue (plasma refill rate, PRR) is the main contributing factor of hemodynamic instability during HD. We aimed to explore the association between fluid overload (FO) and plasma refill rate (PRR) in chronic HD patients. Method Pre-HD FO [l] was assessed once per subject by BIS (Body Composition Monitor; Fresenius Medical Care) in four urban HD dialysis clinics in the U.S. For each treatment within 30 days before and after the BIS measurement, we calculated the respective pre-HD FO by assuming that differences in pre-HD body weight were equivalent to differences in FO. We then used intradialytic hematocrit (measured with the Crit-Line® Monitor, Fresenius Medical Care) and ultrafiltration data to quantify the average PRR, normalized by body weight (Wang et al. Kidney360, 2023): To calculate the starting blood volume (BV), we first calculated the ending BV using the Nadler equation, followed by back-calculating the starting BV based on the cumulative change in relative BV. Plasma refill volume was calculated as the sum of the changes in blood volume and ultrafiltration volume; plasma refill volume was then divided by treatment time and estimated clinical dry weight to calculate the PRR [ml/kg/hr]. Results We analyzed 746 HD sessions from 79 patients (age 61 ± 15 years; 52 (66%) males; 41 (52%) black and 33 (42%) white). Across all HD sessions, PRR was positively associated with FO [slope estimate 0.92 (95% confidence interval 0.83 to 1.02) ml/kg/hr per 1 l of FO, P value &amp;lt; 0.0001] (Figure 1). This was also the case in subgroup analyses of fluid depleted (r = 0.94, P&amp;lt;0.001), normohydrated (r = 1.03, P&amp;lt;0.0001), and fluid overloaded subjects (r = 0.83, P&amp;lt;0.0001). Conclusion Across the entire fluid status spectrum, from fluid depletion to fluid overload, higher FO was associated with higher PRR on average (overall, an increase of 0.92 ml/kg/hr in PRR for each additional liter of FO). While patients with greater FO would be expected to better tolerate higher ultrafiltration rates, there is large inter-individual variability in PRR. Further investigation of the utility of PRR throughout HD may offer novel insights into fluid management and intradialytic symptom mitigation.
Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B (2022)

Safe and effective vaccines are needed to end the COVID-19 pandemic. Here, we report the preclinical development of a lipid nanoparticle–formulated SARS-CoV-2 mRNA vaccine, PTX-COVID19-B. PTX-COVID19-B was chosen among three candidates after the initial mouse vaccination results showed that it elicited the strongest neutralizing antibody response against SARS-CoV-2. Further tests in mice and hamsters indicated that PTX-COVID19-B induced robust humoral and cellular immune responses and completely protected the vaccinated animals from SARS-CoV-2 infection in the lung. Studies in hamsters also showed that PTX-COVID19-B protected the upper respiratory tract from SARS-CoV-2 infection. Mouse immune sera elicited by PTX-COVID19-B vaccination were able to neutralize SARS-CoV-2 variants of concern, including the Alpha, Beta, Gamma, and Delta lineages. No adverse effects were induced by PTX-COVID19-B in either mice or hamsters. Based on these results, PTX-COVID19-B was authorized by Health Canada to enter clinical trials in December 2020 with a phase 2 clinical trial ongoing.
Rough set‐based proteochemometrics modeling of G‐protein‐coupled receptor‐ligand interactions (2006)

G-Protein-coupled receptors (GPCRs) are among the most important drug targets. Because of a shortage of 3D crystal structures, most of the drug design for GPCRs has been ligand-based. We propose a novel, rough set-based proteochemometric approach to the study of receptor and ligand recognition. The approach is validated on three datasets containing GPCRs. In proteochemometrics, properties of receptors and ligands are used in conjunction and modeled to predict binding affinity. The rough set (RS) rule-based models presented herein consist of minimal decision rules that associate properties of receptors and ligands with high or low binding affinity. The information provided by the rules is then used to develop a mechanistic interpretation of interactions between the ligands and receptors included in the datasets. The first two datasets contained descriptors of melanocortin receptors and peptide ligands. The third set contained descriptors of adrenergic receptors and ligands. All the rule models induced from these datasets have a high predictive quality. An example of a decision rule is "If R1_ligand(Ethyl) and TM helix 2 position 27(Methionine) then Binding(High)." The easily interpretable rule sets are able to identify determinative receptor and ligand parts. For instance, all three models suggest that transmembrane helix 2 is determinative for high and low binding affinity. RS models show that it is possible to use rule-based models to predict ligand-binding affinities. The models may be used to gain a deeper biological understanding of the combinatorial nature of receptor-ligand interactions.
Phostensin enables lymphocyte integrin activation and population of peripheral lymphoid organs (2022)

Rap1 GTPase drives assembly of the Mig-10/RIAM/Lamellipodin (MRL protein)-integrin-talin (MIT) complex that enables integrin-dependent lymphocyte functions. Here we used tandem affinity tag-based proteomics to isolate and analyze the MIT complex and reveal that Phostensin (Ptsn), a regulatory subunit of protein phosphatase 1, is a component of the complex. Ptsn mediates dephosphorylation of Rap1, thereby preserving the activity and membrane localization of Rap1 to stabilize the MIT complex. CRISPR/Cas9-induced deletion of PPP1R18, which encodes Ptsn, markedly suppresses integrin activation in Jurkat human T cells. We generated apparently healthy Ppp1r18-/- mice that manifest lymphocytosis and reduced population of peripheral lymphoid tissues ascribable, in part, to defective activation of integrins αLβ2 and α4β7. Ppp1r18-/- T cells exhibit reduced capacity to induce colitis in a murine adoptive transfer model. Thus, Ptsn enables lymphocyte integrin-mediated functions by dephosphorylating Rap1 to stabilize the MIT complex. As a consequence, loss of Ptsn ameliorates T cell-mediated colitis.
Electroreduction of Carbon Monoxide Over a Copper Nanocube Catalyst: Surface Structure and pH Dependence on Selectivity (2016)

Abstract The activity and selectivity for CO 2 /CO reduction over Cu electrodes is strongly dependent on the local surface structure of the catalyst and the pH of the electrolyte. Here we investigate a unique, Cu nanocube surface (CuCube) as a CO reduction electrode under neutral and basic pH by using online electrochemical mass spectroscopy (OLEMS) to determine the onset potentials and relative intensities of methane and ethylene production. To relate the unique selectivity to the surface structure, the CuCube surface reactivity is compared to polycrystalline Cu and three single crystals under the same reaction conditions. We find that the high selectivity for ethylene over the CuCube surface is most comparable to the Cu(1 0 0) surface, which has a cubic unit cell. However, the suppression of methane production over CuCube is unique to that particular surface. A basic pH is shown to enhance ethylene selectivity on all surfaces, and again the CuCube surface is unique.