gebhart/patrepeval huggingface dataset:
Multiecho time‐resolved acquisition (META): A high spatiotemporal resolution dixon imaging sequence for dynamic contrast‐enhanced MRI (2009)

META is a promising high spatiotemporal resolution imaging sequence for capturing the fast dynamics of hyperenhancing hepatic lesions and provides robust fat suppression even at 3T.
Independent and cumulative coeliac disease-susceptibility loci are associated with distinct disease phenotypes (2021)

The phenotype of coeliac disease varies considerably for incompletely understood reasons. We investigated whether established coeliac disease susceptibility variants (SNPs) are individually or cumulatively associated with distinct phenotypes. We also tested whether a polygenic risk score (PRS) based on genome-wide associated (GWA) data could explain the phenotypic variation. The phenotypic association of 39 non-HLA coeliac disease SNPs was tested in 625 thoroughly phenotyped coeliac disease patients and 1817 controls. To assess their cumulative effects a weighted genetic risk score (wGRS39) was built, and stratified by tertiles. In our PRS model in cases, we took the summary statistics from the largest GWA study in coeliac disease and tested their association at eight P value thresholds (P<sub>T</sub>) with phenotypes. Altogether ten SNPs were associated with distinct phenotypes after correction for multiple testing (P<sub>EMP2</sub> ≤ 0.05). The TLR7/TLR8 locus was associated with disease onset before and the SH2B3/ATXN2, ITGA4/UBE2E3 and IL2/IL21 loci after 7 years of age. The latter three loci were associated with a more severe small bowel mucosal damage and SH2B3/ATXN2 with type 1 diabetes. Patients at the highest wGRS39 tertiles had OR > 1.62 for having coeliac disease-related symptoms during childhood, a more severe small bowel mucosal damage, malabsorption and anaemia. PRS was associated only with dermatitis herpetiformis (P<sub>T</sub> = 0.2, P<sub>EMP2</sub> = 0.02). Independent coeliac disease-susceptibility loci are associated with distinct phenotypes, suggesting that genetic factors play a role in determining the disease presentation. Moreover, the increased number of coeliac disease susceptibility SNPs might predispose to a more severe disease course.
Excimer-laser-annealed poly-Si thin-film transistors (1993)

The crystallization of alpha -Si:H into poly-Si using an excimer laser has been examined. The resulting microstructure was found to be stratified into a large-grain surface region, formed from the liquid phase, and a fine-grain underlying layer, thought to be formed by solid phase crystallization. The threshold beam energies for these sequential phase changes were identified from surface reflectance measurements after crystallization and the energies increased with diminishing hydrogen content of the material. The electrical characteristics of thin-film transistors made with material crystallized at energies close to the melt threshold could be correlated with the limited depth of large-grain material. For significantly higher beam energies, coplanar structures showed a severe degradation in leakage current due to lateral diffusion of phosphorus, across the channel from the source and drain regions. When this effect was avoided, thin-film transistors with field-effect mobilities up to 160 cm/sup 2//V-s and on/off current ratios up to 10/sup 8/ were obtained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Production of an Extracellular Toxic Complex by Various Strains of Pseudomonas Cepacia (1989)

Six isolates of Pseudomonas cepacia, representing various serotypes of the organism and possessing similar degrees of virulence in mice, were examined for their production of an extracellular toxic complex (ETC) in vitro. This compound is lethal for mice and produces extensive lung pathology in rats; it is composed of a surface carbohydrate antigen, lipopolysaccharide and protein. All six isolates produced the ETC. The LD50 values for the six ETC preparations ranged from 395 micrograms for strain 61g to 1750 micrograms for strain 90ee. Only two of the six ETC preparations contained ketodeoxyoctonate detectable by the methods used, and these two were the most toxic. Rabbit antiserum to the ETC of a serotype D strain could significantly protect mice only against serotype D strains. Examination of the various phases of growth of P. cepacia showed that there was extracellular release of the ETC beginning in the early logarithmic phase and continuing through the late stationary phase. The presence of the ETC in the supernatant fluids was due to release of this material rather than to cell lysis. In addition, at least one strain of P. cepacia was shown to produce an alginic acid-like compound.
Supplementary Data and Methods from Expression of the Androgen Receptor Governs Radiation Resistance in a Subset of Glioblastomas Vulnerable to Antiandrogen Therapy (2023)

&lt;p&gt;Supplementary Figure S1: Additional expression data and comparisons of AR expression by subtype, age, sex, and common molecular alterations. Supplementary Figure S2. Tumor growth plots and mice weights for in vivo studies. Supplementary Figure S3: Heat map of down-regulated genes from the GBM 26 RNA-seq experiment. Supplementary Figure S4: Effects of seviteronel on dsDNA break repair in AR-positive and negative models post-radiation. Supplementary Figure S5: Effects of enzalutamide on dsDNA break repair in AR-positive and negative models post-radiation. Supplementary Figure S6. Effects of enzalutamide and seviteronel on alkaline tail moment in AR-positive models post-radiation. Method: alkaline comet assay.&lt;/p&gt;
Guaranteed Performance Region in Fading Orthogonal Space-Time Coded Broadcast Channels (2007)

Recently, the capacity region of the MIMO broadcast channel (BC) was completely characterized and duality between MIMO multiple access channel (MAC) and MIMO BC with perfect channel state information (CSI) at transmitter and receiver was established. In this work, we propose a MIMO BC approach in which only information about the channel norm is available at the base and hence no dirty paper precoding (DPC) can be applied. However, a certain set of individual performances in terms of MSE or zero-outage rates can be guaranteed at any time by applying an orthogonal space time block code (OSTBC). The guaranteed MSE region without superposition coding is characterized in closed form and the impact of diversity, fading statistics, and number of transmit antennas is analyzed. The guaranteed MSE region with superposition coding is also studied. Finally, the guaranteed sum MSE is briefly discussed.
Late - Cycle Injection of Air/Oxygen - Enriched Air for Diesel Exhaust Emissions Control (2000)

Reduce the ''Engine Out'' particulates using the ''In Cylinder'' technique of late cycle auxiliary gas injection (AGI). Reduce the ''Engine Out'' NOx by combining AGI with optimization of fuel injection parameters. Maintain or Improve the Fuel Efficiency.
GEM 231, a second-generation antisense agent complementary to protein kinase A RIα subunit, potentiates antitumor activity of irinotecan in human colon, pancreas, prostate and lung cancer xenografts (2002)

GEM 231, a second-generation antisense oligonucleotide targeted against the RIalpha subunit of protein kinase A (PKA) was co-administered with the chemotherapeutic agent irinotecan, a topoisomerase-I inhibitor, to study the antitumor efficacy of the combination in nude mice bearing various human tumor xenografts. The combination treatment of GEM 231 and irinotecan produced enhanced and prolonged tumor-growth inhibition, compared with irinotecan monotherapy, against human colon (HCT-116), pancreas (Panc-1), prostate (PC3) and lung (SKMES) tumors in mice. The extent of tumor-growth inhibition, however, varied among the different tumor models studied. The tumor-growth inhibition depended on the dose of GEM 231 co-administered with irinotecan. The combination of GEM 231 (20 mg/kg, i.p., 5 days on 2 days off x 7) and irinotecan (50 mg/kg, i.v., qwk x 3) produced significantly longer tumor-growth delay than did irinotecan administered alone. Importantly, the co-administration of irinotecan and GEM 231 did not result in higher toxicity compared with monotherapies in the several tumor models tested. These results suggest that the use of irinotecan in combination with GEM 231 may increase the therapeutic index of irinotecan in cancer patients.
Characterization of STAT3 expression, signaling and inhibition in feline oral squamous cell carcinoma (2015)

These data demonstrate that LLL12 has biologic activity against a feline OSCC cell line expressing pSTAT3 and that STAT3 represents a target for therapeutic intervention in this disease. However, given the up-regulation of several STAT3 transcriptional targets following treatment, further investigation of STAT3 and its related signaling pathways in OSCC is warranted.
Immunomodulation by Tachykinin Neuropeptidesa (1990)

Substance P (SP) is an 11-amino-acid neuropeptide found in sensory neurons in the peripheral nervous system. In addition to having well-characterized functions as a peptide neurotransmitter, it also plays a major role in modulating inflammatory and immune responses. SP can alter the proliferative and physiological responses of both lymphocytes and macrophages. These effects are mediated by specific high-affinity SP receptors which have been characterized both kinetically and biochemically. The principle SP binding protein present on human lymphocyte cell membranes is a 58,000-MW hydrophobic glycoprotein. Cellular responses subsequent to the binding of substance P to its receptor that have been identified in various cell populations include phosphatidyl inositol turnover, arachidonic acid metabolism, immunoglobulin synthesis, and enzyme production and secretion. Evidence also suggests that SP modulation of inflammation is a factor in the pathophysiology of certain diseases such as rheumatoid arthritis.
Utilization of the Space Station Detergent IGEPON by a Candidate Organism for Use in a Space Biological Waste Reactor (1998)

&lt;div class="htmlview paragraph"&gt;The microgravity environment of space introduces a major new variable for consideration that will affect the design and operation of bioreactors. Adequate aeration for aerobic bioreactors will be a challenge as will gas/liquid separation, removal of carbon dioxide and other bacterial metabolic waste products, control algorithms, and overall performance assessment. These challenges must be addressed in order to fully assess the efficacy of biological approaches to the recovery of potable water from wastewater in microgravity. The first step in this process is to define the fermentation parameters of the organism or consortia that will be used in these space bioreactors.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;This study was designed to investigate the ability of bacteria to degrade the space station detergent IGEPON. The ultimate goal was to define the growth conditions required by an IGEPON-utilizing bacteria, so that these conditions could be used in a flight experiment designed to prove the concept of biological waste conversion. To this end, we isolated an &lt;i&gt;Acinetobacter calcoaceticus&lt;/i&gt; (JSC 96121) that could use IGEPON and defined its requirements for growth. The growth conditions required for the batch utilization of IGEPON by JSC 96121 were: excess oxygen levels; a temperature of 25 to 35°C; a pH 6.0 to 8.0; 40 to 60 g/L IGEPON; 0.225 g/L NH&lt;sub&gt;3&lt;/sub&gt;&lt;sup&gt;+&lt;/sup&gt;; and 1.36 g/L PO&lt;sub&gt;4&lt;/sub&gt;. JSC 96121 utilization of IGEPON did not require vitamins or cofactors. Other required inorganic salts could be supplied by tap water.&lt;/div&gt;
Melanotropins as Drugs for the Treatment of Obesity and Other Feeding Disorders: Potential and Problems (2009)

Current biological and pharmacological evidence suggests that the melanocortin 4 and melanocortin 3 receptors which are seven transmembrane G-protein coupled receptors (GPCRs) are involved in various aspects of energy balance and feeding behaviors in animals including humans. The natural endogenous ligands for these receptors are products of the gene pro-opiomelanocortin (POMC), and include alpha-melanocyte stimulating hormone, gamma-melanocyte stimulating hormone and perhaps other modified products of POMC. Thus well designed agonists and antagonists of these ligands might serve as drugs for the treatment of feeding disorders. However, these melanotropin peptides also can have other biological activities that involve the MC3R and MC4R, and these other biological properties will need to be modulated in ligands that are likely to be useful drugs for feeding disorders. Current progress in these areas with special emphasis on the MC3R will be discussed along with possible new directions that might be fruitful in these important aspects of contemporary biology and medicine.
High voltage GaN‐on‐silicon HEMT (2013)

Abstract M/A‐COM Technology Solutions has continued in the joint development efforts sponsored by the Department of Energy with MIT main campus and MIT Lincoln Labs to develop GaN on silicon three terminal high voltage/high current HEMT switching devices. The first year developmental goals were for a three terminal structure that has a reverse breakdown characteristic of &gt;1200 V and is capable of switching 10 amperes of current. An average three terminal breakdown of 1322 V was achieved on a single finger 250 µm GaN on silicon HEMT device utilizing a source connected field plate with a 4.5 µm drain region overlap. An individual device breakdown on a single finger 250 µm GaN on silicon HEMT device with a SCFP of &gt;1630 V was measured at a current of 250 µA (1mA/mm) – One of the highest yet reported for GaN on silicon in the industry. (© 2013 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Counting algorithms for linkage: correction to Morton and Collins (1991)

In a recent paper, Morton & Collins (1990) claimed: (1) that the Lander-Green algorithm for genetic linkage analysis is not the EM algorithm for finding the maximum likelihood map; and (2) that a proposed alternative algorithm does have these properties. Here, we show that these assertions are both incorrect: the Lander-Green algorithm is an EM algorithm, while the Morton-Collins algorithm is not. We note that Morton and Collins concur with these conclusions.
Dependence of hydrophobic properties versus the chemical composition in a AlCoCrCuFeNi high entropy alloy (2011)

International audience
Diverse Embedding Neural Network Language Models. (2014)

We propose Diverse Embedding Neural Network (DENN), a novel architecture for language models (LMs). A DENNLM projects the input word history vector onto multiple diverse low-dimensional sub-spaces instead of a single higher-dimensional sub-space as in conventional feed-forward neural network LMs. We encourage these sub-spaces to be diverse during network training through an augmented loss function. Our language modeling experiments on the Penn Treebank data set show the performance benefit of using a DENNLM.
Macroscopic changes of the organs with the application of a niosomal form of antitumor medicine in experiment (2022)

[1]. , , , . , , , . -, - -. . [2]. . .
ChemInform Abstract: A Straightforward Synthesis of L‐Lactones from D‐Glucose. A Simple Entry into L‐Sugars. (1988)

Abstract The compounds (Ia) and (VIII), prepared from tri‐O‐acetyl‐D‐glucal, are transformed into the unsaturated lactones (V) and (XII).
Bridging the gap between physical location and online social networks (2010)

This paper examines the location traces of 489 users of a location sharing social network for relationships between the users' mobility patterns and structural properties of their underlying social network. We introduce a novel set of location-based features for analyzing the social context of a geographic region, including location entropy, which measures the diversity of unique visitors of a location. Using these features, we provide a model for predicting friendship between two users by analyzing their location trails. Our model achieves significant gains over simpler models based only on direct properties of the co-location histories, such as the number of co-locations. We also show a positive relationship between the entropy of the locations the user visits and the number of social ties that user has in the network. We discuss how the offline mobility of users can have implications for both researchers and designers of online social networks.
Accessing Minimal-Impact Personal Audio Archives (2006)

We've collected personal audio - essentially everything we hear - for two years and have experimented with methods to index and access the resulting data. Here, we describe our experiments in segmenting and labeling these recordings into episodes (relatively consistent acoustic situations lasting a few minutes or more) using the Bayesian information criterion (from speaker segmentation) and spectral clustering
Drum Transcription From Multichannel Recordings With Non-Negative Matrix Factorization (2009)

Publication in the conference proceedings of EUSIPCO, Glasgow, Scotland, 2009
OYE Flavoprotein Reductases Initiate the Condensation of TNT-Derived Intermediates to Secondary Diarylamines and Nitrite (2008)

Polynitroaromatic explosives such as 2,4,6-trinitrophenol (picric acid) and 2,4,6-trinitrotoluene (TNT) are toxic and recalcitrant environmental pollutants. They persist in the environment due to the highly inactivated pi system of their aromatic rings, which are inaccessible to dioxygenases that normally initiate the bacterial aerobic catabolism of (nitro-) aromatic compounds. Aside from reductive transformation of nitro side groups to hydroxylamines, trinitroarenes are prone to aromatic ring reductions by some flavin reductases to yield Meisenheimer mono and dihydride complexes. Here we show that the simultaneous accumulation of Meisenheimer complexes and aromatic hydroxylamines derived from TNT gives rise to the condensation of both types of reactive intermediates to secondary diarylamines and nitrite as the end-products of this environmentally relevant reaction sequence. As a consequence, overall mass balances of aerobic biotransformations of TNT become possible for the first time. In our study, the process of TNT activation was enzymatically initiated by the xenobiotic reductase B (XenB)-like flavin reductase of Pseudomonas putida JLR11 and then completed chemically by autodimerization. The structures of the formed end products were unequivocally elucidated by NMR.
Mesostructured TiO<SUB>2</SUB> and SiO<SUB>2</SUB> as High Specific Surface Area Coatings for Love Wave Gas Sensors (2011)

International audience
Utilizing Structure‐Activity Relationships to Design Non ‐ Oxime Reactivators (2018)

Organophosphorus nerve agents are highly toxiccompounds that pose a threat worldwide. These compounds induce toxicity bycovalently binding to the active site serine of acetylcholinesterase, whichresults in inhibition of the native enzyme function. Without functionalacetylcholinesterase, levels of the neurotransmitter acetylcholine inneuromuscular junctions rise quickly, causing overstimulation of the nervoussystem, which can quickly culminate in death if not treated. Current treatmentsrely on small molecules that interact with inhibited enzyme to disrupt thecovalently bound phosphorus moiety at the active site. The most effectivemolecules incorporate a pyridinium oxime which acts via direct nucleophilicattack on the phosphorus to achieve reactivation of the enzyme. These compoundshave limited effectiveness because the charged portion of the molecule does notallow them to cross into the central nervous system where acetylcholinesteraseinhibition is most harmful. We recently characterized a small moleculereactivator (4‐amino‐2‐((diethylamino)methyl)phenol [ADOC]) that does not utilizean oxime but is capable of reactivating nerve agent‐inhibited enzyme as well asor better than current treatments; these results have been used to inform thedesign of additional novel compounds. This study describes the in vitro characterization of these novelcompounds as reactivators of phosphonylated human acetylcholinesterase. Support or Funding Information *Thisresearch was supported in part by an appointment to the Postgraduate ResearchParticipation Program at the U.S. Army Medical Research Institute of ChemicalDefense administered by the Oak Ridge Institute for Science and Educationthrough an interagency agreement between the U.S. Department of Energy and theU. S. Army Medical Research and Materiel Command. Thisresearch was supported by the Defense Threat Reduction Agency – Joint Scienceand Technology Office, Medical S&amp;T Division. The views expressedin this abstract are those of the author(s) and do not reflect the officialpolicy of the Department of Army, Department of Defense, or the U.S.Government. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
Design and synthesis of new ferroelectric liquid crystals. 14. An approach to the stereocontrolled synthesis of polar organic thin films for nonlinear optical applications (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDesign and synthesis of new ferroelectric liquid crystals. 14. An approach to the stereocontrolled synthesis of polar organic thin films for nonlinear optical applicationsDavid M. Walba, M. Blanca Ros, Noel A. Clark, Renfan Shao, Michael G. Robinson, Jian Yu Liu, Kristina M. Johnson, and David DoroskiCite this: J. Am. Chem. Soc. 1991, 113, 14, 5471–5474Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/ja00014a059https://doi.org/10.1021/ja00014a059research-articleACS PublicationsRequest reuse permissionsArticle Views198Altmetric-Citations73LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts