gebhart/patrepeval huggingface dataset:
Karyological Studies in Root-Tip Cells of Cannabis sativa var. indica. (1999)

Chromosomal study was carried in the dividing root-tip cells of Cannabis sativa (Family : Cannabinaceae). The diploid chromosome number of this species is 2n=20. Karyotype analysis reveals that all the 9 chromosomes in female somatic cells are metacentric and 1 chromosome is submetacentric whereas the X and Y chromosome in male cells is sub-metacentric. The Y chromosome is longer than X chromosome. The third pair bears the satellite.
Self-managing techniques for storage resource management (2006)

The increasing reliance on online information in our daily lives had called for a rethinking of how people manage and maintain computer systems. As information has become more valuable and computing environments more complex, improved manageability has become key to ensuring availability. The sheer size of enterprise-scale storage systems coupled with the diversity and variability of application workloads makes their management non-trivial. Not surprisingly, numerous studies have shown that management costs have become a significant fraction of the total cost of ownership of large storage systems. Traditionally storage management tasks have been performed manually by administrators using a combination of experience, rules of thumb and trial and error. This increases the chance of a misconfigured or sub-optimally configured system. The cost of such misconfigurations can be high, since even a short downtime can result in substantial revenue losses. So, although storage is cheap, storage management is costly and storage mismanagement costlier. This argues the need for an automated, seamless and intelligent way to manage the storage resource. 
In this thesis, I propose self-managing techniques, specifically for resource management, to improve the manageability of large-scale storage systems. I have focused on techniques for automating two common storage allocation tasks: storage bandwidth allocation and storage space allocation. Large scale storage systems host data objects of multiple types which are accessed by applications with diverse service requirements. I have developed an online measurement based technique as well as one based on learning to dynamically partition bandwidth between application classes. Storage allocation algorithms that determine object placement, and thus the performance, are crucial to the success of a storage system. For a self-managing storage system a suitable placement technique is one that has low management overhead and delivers agreeable performance. In this context, I empirically compare different placement techniques to determine their suitability for large-scale storage systems, Finally, I also present techniques to minimize the amount of data displaced when remapping objects to eliminate hotspots.
Study on Ship Motions and Capsizing in Following Seas (1989)

In the interest of brevity, practical equations for ship motion and capsizing in following seas are derived. Simulations of capsizing are carried out by using Tasai's and Inoue's practical formulas for the hydrodynamic coefficients. Finally a material to discuss safety against capsizing is presented for novelty.
A statistical theory of polydisperse block copolymer systems under weak supercrystallization (1994)

Abstract A statistical theory of conjugated macro‐ and microphase separation in flexile polydisperse block copolymer systems with a given arbitrary molecular structural distribution is developed in the mean field approximation. A special attention is paid to recognizing and calculating all terms having the least order of magnitude to be taken into account. To this end a special procedure is elaborated enabling to distinguish between strongly and weakly fluctuating order parameters characterizing polydisperse systems and to construct explicitly a one‐field parametrization of the free energy of the systems under investigation. The contribution of so‐called higher harmonics and effect of a redistribution of macromolecules among coexisting phases are taken into account therewith by a proper renormalization of the fourth vertex of the corresponding effective hamiltonian. In order to compare the presented approach and other existing theories phase diagrams of molten polydisperse diblock copolymer are built numerically in approximations corresponding to different theories. It is shown that our rigorous approach results in phase diagrams qualitatively different from the conventional ones. In particular, we predict the existence of one‐phase region having a quasicrystal symmetry and regions of coexistence of this phase with disordered phase and one having the symmetry of the body‐centered‐oubic lattice as well as a considerable shrinking of the region of the existence of the lamellar phase.
The Reaction Mechanism for the Organocatalytic Ring-Opening Polymerization of l-Lactide Using a Guanidine-Based Catalyst: Hydrogen-Bonded or Covalently Bound? (2008)

We have investigated two alternative mechanisms for the ring-opening polymerization of l-lactide using a guanidine-based catalyst, the first involving acetyl transfer to the catalyst, and the second involving only hydrogen bonding to the catalyst. Using computational chemistry methods, we show that the hydrogen bonding pathway is considerably preferred over the acetyl transfer pathway and that this is consistent with experimental information.
Transapical aortic valve replacement through a chronic apical aneurysm (2011)

Transapical aortic valve replacement through an apical aneurysm is traditionally contraindicated because of the risk of severe systemic embolization when thrombi are present. However, a chronic fibrotic aneurysm without apical thrombi carries a low risk of distal embolization and can be safely employed for a transapical transcatheter aortic valve replacement in case of absence of an alternative access site (severe vascular disease, small vascular sizes and diseased calcified aorta). We illustrate our experience with a 73-year-old patient suffering from symptomatic aortic valve stenosis, coronary artery disease with occluded left anterior descending artery, left ventricular apical aneurysm and severe peripheral vascular disease, who successfully underwent a transapical 26 mm Sapien™ XT stent-valve implantation through the fibrotic thin akinetic apical wall.
58.5: Late‐News Paper : 14.3 inch Active Matrix‐Based Plastic Electrophoretic Display Using Low Temperature Processes (2007)

Abstract A 14.3‐inch black and white plastic electrophoretic display (EPD) was developed at the resolution of 1280 × 900 lines (112 ppi). All of the processes of TFT and electrophoretic sheet (EPS) lamination were not only carried out below 120°C, but also optimized for large area TFT‐EPD on PEN plastic films.
Cloning of the mast cell protease, RMCP II. Evidence for cell-specific expression and a multi-gene family. (1987)

We have isolated, cloned, and characterized cDNA and genomic DNA corresponding to the mRNA and gene for the rat mast cell protease, RMCP II. The amino acid sequence deduced from the cDNA provides evidence that this protease is synthesized as a precursor, with a signal peptide and additional residues at the N and C termini. RNA homologous to the cDNA is expressed only in mast cells. Analysis of RNA from the two subclasses of mast cell, mucosal and serosal, indicates subclass specific expression of the different proteases found in each of these two subclasses. S1 protection analysis and the sequence of the genomic clone indicate that the serosal mast cell protease, RMCP I, is likely to be coded for by a separate, highly homologous gene. A comparison of the exon/intron structure of the RMCP II gene with genes of related serine proteases further indicates that RMCP II is a member of a family of proteases distinct from those found in the pancreas. We have also isolated a third gene, highly homologous to RMCP II but different from it and from the gene for RMCP I. Analysis of the 5' transcriptional control region of both genes showed striking homology to the TATA box and enhancer regions of the pancreatic proteases.
Extended Koopman Models (2020)

We introduce two novel generalizations of the Koopman operator method of nonlinear dynamic modeling. Each of these generalizations leads to greatly improved predictive performance without sacrificing a unique trait of Koopman methods: the potential for fast, globally optimal control of nonlinear, nonconvex systems. The first generalization, Convex Koopman Models, uses convex rather than linear dynamics in the lifted space. The second, Extended Koopman Models, additionally introduces an invertible transformation of the control signal which contributes to the lifted convex dynamics. We describe a deep learning architecture for parameterizing these classes of models, and show experimentally that each significantly outperforms traditional Koopman models in trajectory prediction for two nonlinear, nonconvex dynamic systems.
Automatic Lesion Incidence Estimation and Detection in Multiple Sclerosis Using Multisequence Longitudinal MRI (2012)

This fully automated and computationally fast method allows sensitive and specific detection of lesion incidence that can be applied to large collections of images. Using the explicit form of the statistical model, SuBLIME can easily be adapted to cases when more or fewer imaging sequences are available.
Design and operation of a portable scanner for high performance microchip capillary array electrophoresis (2010)

We have developed a compact, laser-induced fluorescence detection scanner, the multichannel capillary array electrophoresis portable scanner (McCAEPs) as a platform for electrophoretic detection and control of high-throughput, integrated microfluidic devices for genetic and other analyses. The instrument contains a confocal optical system with a rotary objective for detecting four different fluorescence signals, a pneumatic system consisting of two pressure/vacuum pumps and 28 individual addressable solenoid valves for control of on-chip microvalves and micropumps, four Polymerase Chain Reaction (PCR) temperature control systems, and four high voltage power supplies for electrophoresis. The detection limit of the instrument is ~20 pM for on-chip capillary electrophoresis of fluorescein dyes. To demonstrate the system performance for forensic short tandem repeat (STR) analysis, two experiments were conducted: (i) electrophoretic separation and detection of STR samples on a 96-lane microfabricated capillary array electrophoresis microchip. Fully resolved PowerPlex(®) 16 STR profiles amplified from 1 ng of 9947A female standard DNA were successfully obtained; (ii) nine-plex STR amplification, sample injection, separation, and fluorescence detection of 100-copy 9948 male standard DNA in a single integrated PCR- capillary electrophoresis microchip. These results demonstrate that the McCAEPs can be used as a versatile control and detection instrument that operates integrated microfluidic devices for high-performance forensic human identification.
Chemical Interaction at the MoO3/CH3NH3PbI3–xClx Interface (2021)

The limited long-term stability of metal halide perovskite-based solar cells is a bottleneck in their drive toward widespread commercial adaptation. The organic hole-transport materials (HTMs) have been implicated in the degradation, and metal oxide layers are proposed as alternatives. One of the most prominent metal oxide HTM in organic photovoltaics is MoO<sub>3</sub>. However, the use of MoO<sub>3</sub> as HTM in metal halide perovskite-based devices causes a severe solar cell deterioration. Thus, the formation of the MoO<sub>3</sub>/CH<sub>3</sub>NH<sub>3</sub>PbI<sub>3-<i>x</i></sub>Cl<i><sub>x</sub></i> (MAPbI<sub>3-<i>x</i></sub>Cl<i><sub>x</sub></i>) heterojunction is systematically studied by synchrotron-based hard X-ray photoelectron spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and Raman spectroscopy. Upon MoO<sub>3</sub> deposition, significant chemical interaction is induced at the MoO<sub>3</sub>/MAPbI<sub>3-<i>x</i></sub>Cl<i><sub>x</sub></i> interface: substoichiometric molybdenum oxide is present, and the perovskite decomposes in the proximity of the interface, leading to accumulation of PbI<sub>2</sub> on the MoO<sub>3</sub> cover layer. Furthermore, we find evidence for the formation of new compounds such as PbMoO<sub>4</sub>, PbN<sub>2</sub>O<sub>2</sub>, and PbO as a result of the MAPbI<sub>3-<i>x</i></sub>Cl<i><sub>x</sub></i> decomposition and suggest chemical reaction pathways to describe the underlying mechanism. These findings suggest that the (direct) MoO<sub>3</sub>/MAPbI<sub>3-<i>x</i></sub>Cl<i><sub>x</sub></i> interface may be inherently unstable. It provides an explanation for the low power conversion efficiencies of metal halide perovskite solar cells that use MoO<sub>3</sub> as a hole-transport material and in which there is a direct contact between MoO<sub>3</sub> and perovskite.
Design and performance analysis of collaborative spatial multiplexing for IEEE 802.16e-based systems (2009)

In this paper, collaborative spatial multiplexing is considered for a system based on IEEE 802.16e. By allowing multiple simultaneous in-sector transmissions on the same time-frequency resources, collaborative spatial multiplexing, also known as collaborative uplink MIMO (cMIMO), increases the peak transmission rates and makes system throughput improvement possible. The objective of this work is to analyze the performance of physical and medium access control (MAC) layers by means of a network-wide simulation so as to enhance system throughput while maintaining other performance metrics such as coverage and post hybrid automatic repeat request (HARQ) error rates. Assuming multiple modes of transmission, e.g., single input-multiple output (SIMO) or multiple input-multiple output (MIMO) are available, this paper describes physical and MAC level techniques related to UL-MIMO, such as receiver algorithms, transmission mode selection, ranking of SIMO/MIMO transmissions, MIMO pairing, HARQ process selection, allocation of bandwidth (burst size) and power, and selection of the modulation and coding scheme. Finally, this paper presents link and system level simulation results that demonstrate that up to 60 percent improvement in average sector throughput is possible for collaborative UL-MIMO without compromising other user performance criteria.
Supplementary Figure 2 from Targeting BCL2 Overcomes Resistance and Augments Response to Aurora Kinase B Inhibition by AZD2811 in Small Cell Lung Cancer (2023)

&lt;p&gt;Supplementary Figure 2 shows polyploidy and apoptosis are inhibited by high BCL2 levels&lt;/p&gt;
Fabrication of Integrated Copper‐Based Nanoparticles/Amorphous Metal–Organic Framework by a Facile Spray‐Drying Method: Highly Enhanced CO2 Hydrogenation Activity for Methanol Synthesis (2021)

We report on Cu/amUiO-66, a composite made of Cu nanoparticles (NPs) and amorphous [Zr<sub>6</sub> O<sub>4</sub> (OH)<sub>4</sub> (BDC)<sub>6</sub> ] (amUiO-66, BDC=1,4-benzenedicarboxylate), and Cu-ZnO/amUiO-66 made of Cu-ZnO nanocomposites and amUiO-66. Both structures were obtained via a spray-drying method and characterized using high-resolution transmission electron microscopy, energy dispersive spectra, powder X-ray diffraction and extended X-ray absorption fine structure. The catalytic activity of Cu/amUiO-66 for CO<sub>2</sub> hydrogenation to methanol was 3-fold that of Cu/crystalline UiO-66. Moreover, Cu-ZnO/amUiO-66 enhanced the methanol production rate by 1.5-fold compared with Cu/amUiO-66 and 2.5-fold compared with γ-Al<sub>2</sub> O<sub>3</sub> -supported Cu-ZnO nanocomposites (Cu-ZnO/γ-Al<sub>2</sub> O<sub>3</sub> ) as the representative hydrogenation catalyst. The high catalytic performance was investigated using in situ Fourier transform IR spectra. This is a first report of a catalyst comprising metal NPs and an amorphous metal-organic framework in a gas-phase reaction.
Preclinical assessment of a novel small molecule inhibitor of tryptophan 2,3-dioxygenase 2 (TDO2) (2014)

Meeting abstracts iTeos leverages the science of LICR to target metabolism of the tumor microenvironment and develops small molecule immunomodulators. TDO2 is a heme-containing enzyme highly expressed in the liver, in specific brain regions and liver/brain tumors. It catalyses the first and rate-
Session details: Demo session 1: demos on video retrieval and 3D (2010)

No abstract available.
High-pressure studies for hydrogen substituted CaFeAsF1−xHx (2012)

High-pressure electrical resistivity measurements have been carried out for CaFeAsH, which has been successfully synthesized very recently. Hydrogen atoms are incorporated as H− ions at the F− sites. In case of CaFeAsF superconductivity appears with Co substitution into Fe, which is considered to be electron doping. In CaFeAsH, superconductivity does not appear at atmospheric pressure, because the isovalent substitution does not affect largely the electronic state. On the other hand, pressure-induced superconductivity appears at 28 K at 5 GPa for CaFeAsF In this study superconducting properties for H substituted materials were investigated by the high-pressure electrical resistivity measurements. For CaFeAsH the pressure-induced superconductivity was confirmed at 28 K at 3 GPa, which is a little smaller than the case of CaFeAsF.
Correlation of C2 Fractures and Vertebral Artery Injury (2010)

Vertebral artery injuries are more likely to occur in C2 fractures with comminuted fractures involving the foramen transversarium, with fractures manifesting bony fragment(s) within the foramen transversarium, or with fractures having greater angulation. These risk factors should be considered when a patient presents with isolated axis fracture.
Personalized HLA typing leads to the discovery of novel HLA alleles and tumor‐specific HLA variants (2022)

Accurate and full-length typing of the HLA region is important in many clinical and research settings. With the advent of next generation sequencing (NGS), several HLA typing algorithms have been developed, including many that are applicable to whole exome sequencing (WES). However, most of these solutions operate by providing the closest-matched HLA allele among the known alleles in IPD-IMGT/HLA Database. These database-matching approaches have demonstrated very high performance when typing well characterized HLA alleles. However, as they rely on the completeness of the HLA database, they are not optimal for detecting novel or less well characterized alleles. Furthermore, the database-matching approaches are also not adequate in the context of cancer, where a comprehensive characterization of somatic HLA variation and expression patterns of a tumor's HLA locus may guide therapy and clinical outcome, because of the pivotal role HLA alleles play in tumor antigen recognition and immune escape. Here, we describe a personalized HLA typing approach applied to WES data that leverages the strengths of database-matching approaches while simultaneously allowing for the discovery of novel HLA alleles and tumor-specific HLA variants, through the systematic integration of germline and somatic variant calling. We applied this approach on WES from 10 metastatic melanoma patients and validated the HLA typing results using HLA targeted NGS sequencing from patients where at least one HLA germline candidate was detected on Class I HLA. Targeted NGS sequencing confirmed 100% performance for the 1st and 2nd fields. In total, five out of the six detected HLA germline variants were because of Class I ambiguities at the third or fourth fields, and their detection recovered the correct HLA allele genotype. The sixth germline variant let to the formal discovery of a novel Class I allele. Finally, we demonstrated a substantially improved somatic variant detection accuracy in HLA alleles with a 91% of success rate in simulated experiments. The approach described here may allow the field to genotype more accurately using WES data, leading to the discovery of novel HLA alleles and help characterize the relationship between somatic variation in the HLA region and immunosurveillance.
Identification of two distinct intracellular sites that contribute to the modulation of multidrug resistance in P388/ADR cells expressing P‐glycoprotein (2002)

Although the ability of chemosensitizers to modulate P-glycoprotein (PGP)-based multidrug resistance (MDR) has been extensively studied, relatively little is known about the cellular pharmacology of the PGP inhibitors themselves in MDR cells. The studies described here have correlated the in vitro accumulation and retention properties of verapamil (VRP) in murine P388 (sensitive) and P388/ADR (MDR) cells with doxorubicin (DOX) uptake and cytotoxicity modulation characteristics in order to better understand VRP-tumor cell interactions that give rise to MDR modulation. VRP is rapidly taken up by DOX-sensitive and -resistant P388 cells where greater than 50% maximal VRP uptake occurs within 10 min of initial exposure at 37 degrees C. Whereas chemosensitization and DOX uptake in P388/ADR cells increase with increasing VRP concentration until a plateau is achieved at approximately 5 microM VRP, cellular modulator levels increase proportionally with increasing VPR concentrations beyond 20 microM. Subsequent to removal of noncell-associated modulator, VRP levels in both sensitive and resistant cells rapidly fall below 10% of those obtained at uptake equilibrium. However, a residual amount of VRP remains associated with the cells for extended time periods after the cells are washed. Pulse exposures of P388/ADR cells to high concentrations of VRP (50-100 microM) are capable of providing extended cell-associated VRP levels comparable to those obtained with continuous exposure at biologically active VRP concentrations (1-3 microM) and this leads to chemosensitization. These results are consistent with the existence of high- and low-affinity intracellular VRP pools in P388 MDR cells, both of which can contribute to the reversal of drug resistance. It is suggested that these properties should be taken into consideration during the design and evaluation of preclinical in vivo MDR models where pulsed exposure to high concentrations of resistance modulators often occurs. Special attention must be given to whether such high concentration pulses are desirable and/or achievable in relevant clinical settings.
Effects of TAK‐802, a novel acetylcholinesterase inhibitor, and tamsulosin, an α 1 ‐adrenoceptor antagonist, and their synergistic effects on the urodynamic characteristics in a guinea‐pig model of functional bladder outlet obstruction (2005)

These results suggest that TAK-802 and tamsulosin have synergistic effects in increasing the Qmax and voiding efficiency, and TAK-802 does not inhibit the decreasing effect of tamsulosin on urethral resistance. That TAK-802 increased Pves when administered alone implies that monotherapy using an acetylcholinesterase inhibitor should be withheld in patients with voiding dysfunction caused by obvious bladder outlet obstruction with benign prostatic hyperplasia, to avoid disorders of the upper urinary tracts, and it should be used with an alpha1-adrenoceptor antagonist. Whether TAK-802 combined with an alpha1-adrenoceptor antagonist confers additional clinical benefit is not yet known.
Effect of respiratory motion on free‐breathing 3D stack‐of‐radial liver relaxometry and improved quantification accuracy using self‐gating (2019)

The proposed self-gating method corrects the respiratory motion bias and enables accurate free-breathing stack-of-radial quantification of liver <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msubsup><mml:mi>R</mml:mi><mml:mn>2</mml:mn><mml:mo>∗</mml:mo></mml:msubsup></mml:math> .
Brief announcement (2009)

We define and study the bandwidth determination problem in ad-hoc P2P environments. Using point-to-point bandwidth probes, the goal is to quickly determine each host's upload and download bandwidth. We present matching upper and lower bounds on the number of probing rounds required by any algorithm. We also devise algorithms which, for realistic bandwidth distributions, beat the lower bounds.