gebhart/patrepeval huggingface dataset:
Retroregulation of the synthesis of ribosomal proteins L14 and L24 by feedback repressor S8 in Escherichia coli. (1989)

Previous studies on regulation of the spc operon containing genes for ribosomal proteins have shown that S8, encoded by the fifth gene of the operon in Escherichia coli, is a translational repressor and regulates the synthesis of the third gene product (L5) and distal gene products by acting at a site near the L5 mRNA translation initiation site. We have now shown that S8 also regulates the synthesis of the first and second gene products (L14 and L24) of the operon by acting at the same mRNA target site--that is, the site located distal to sites coding for L14 and L24--and that mRNA degradation is involved in this retroregulation. It was shown that single base substitutions in the target site, which abolish repression of the synthesis of L5 and L5-distal gene products by S8, also cause derepression of L14-L24 synthesis. Inhibition of L14-L24 synthesis by S8 was also shown by overproducing S8 in trans from a plasmid carrying the S8 gene under lac promoter/operator control. A strain carrying temperature-sensitive mutations in genes for polynucleotide phosphorylase and RNase II was found upon shift to nonpermissive temperature to show higher differential synthesis rates of L14-L24 (and L5) relative to those of several L5-distal spc operon gene products. We suggest that repression of distal ribosomal protein synthesis by S8 triggers nucleolytic cleavage of spc operon mRNA, followed by mRNA degradation by these 3'- to 5'- exonucleases, which is then responsible for inhibition of L14-L24 synthesis.
Eventually Consistent: Not What You Were Expecting? (2014)

Storage systems continue to lay the foundation for modern Internet services such as Web search, e-commerce, and social networking. Pressures caused by rapidly growing user bases and data sets have driven system designs away from conventional centralized databases and toward more scalable distributed solutions, including simple NoSQL key-value storage systems, as well as more elaborate NewSQL databases that support transactions at scale.
DSP complexity of mode-division multiplexed receivers (2012)

The complexities of common equalizer schemes are analytically analyzed in this paper in terms of complex multiplications per bit. Based on this approach we compare the complexity of mode-division multiplexed digital signal processing algorithms with different numbers of multiplexed modes in terms of modal dispersion and distance. It is found that training symbol based equalizers have significantly lower complexity compared to blind approaches for long-haul transmission. Among the training symbol based schemes, OFDM requires the lowest complexity for crosstalk compensation in a mode-division multiplexed receiver. The main challenge for training symbol based schemes is the additional overhead required to compensate modal crosstalk, which increases the data rate. In order to achieve 2000 km transmission, the effective modal dispersion must therefore be below 6 ps/km when the OFDM specific overhead is limited to 10%. It is concluded that for few mode transmission systems the reduction of modal delay is crucial to enable long-haul performance.
Reperfusion injury is reduced in skeletal muscle by inhibition of inducible nitric oxide synthase (2003)

This study evaluated the effects of the selective inducible nitric oxide synthase (iNOS) inhibitor N-[3-(aminomethyl)benzyl]acetamidine (1400W) on the microcirculation in reperfused skeletal muscle. The cremaster muscles from 32 rats underwent 5 h of ischemia followed by 90 min of reperfusion. Rats received either 3 mg/kg 1400W or PBS subcutaneously before reperfusion. We found that blood flow in reperfused muscles was <45% of baseline in controls but sharply recovered to near baseline levels in 1400W-treated animals. There was a significant (P < 0.01 to P < 0.001) difference between the two groups at each time point throughout the 90 min of reperfusion. Vessel diameters remained <80% of baseline in controls during reperfusion, but recovered to the baseline level in the 1400W group by 20 min, and reached a maximum of 121 +/- 14% (mean +/- SD) of baseline in 10- to 20-micro m arterioles, 121 +/- 6% in 21- to 40-micro m arterioles, and 115 +/- 8% in 41- to 70-micro m arteries (P < 0.01 to P < 0.001). The muscle weight ratio between ischemia-reperfused (left) and non-ischemia-reperfused (right) cremaster muscles was 193 +/- 42% of normal in controls and 124 +/- 12% in the 1400W group (P < 0.001). Histology showed that neutrophil extravasation and edema were markedly reduced in 1400W-treated muscles compared with controls. We conclude that ischemia-reperfusion leads to increased generation of NO from iNOS in skeletal muscle and that the selective iNOS inhibitor 1400W reduces the negative effects of ischemia-reperfusion on vessel diameter and muscle blood flow. Thus 1400W may have therapeutic potential in treatment of ischemia-reperfusion injury.
Electrowetting optics and displays: Materials implications on performance and reliability (2011)

Careful selection of all three electrowetting materials: dielectric, polar phase, and non-polar phase, allows for increased performance and reliability for electrowetting devices.
Performance Evaluation of an Electric Vehicle Traction Drive using Si/SiC Hybrid Switches (2021)

The parallel connection of a Silicon (Si)-based IGBT and a Silicon Carbide (SiC)-based MOSFET forming a so called hybrid switch (HyS) can be used to exploit the advantageous features of both semiconductor and materials technologies. In this paper, a HyS-based inverter designed for the application of Electric Vehicle (EV) traction is compared to the conventional inverter assembled with Si-based IGBTs and SiC-based MOS-FETs. According to different standardized driving cycles, EVs operate in low partial load for a considerable amount of the time. Therefore, in this application, semiconductor conduction losses can be considerably reduced when unipolar switches such as MOSFETs are used. All in all, this work shows that the HyS configuration constitutes a good compromise between efficiency and cost when compared to the solution implementing only Si-based IGBT or solely SiC-based MOSFETs.
W-Band SiGe Frequency Doubler With Optimum Harmonic Termination for 14% Efficiency (2021)

A W-band balanced frequency doubler with an optimized harmonic termination and neutralization technique is proposed for high output power and high conversion efficiency in a 90-nm SiGe process. The proposed design demonstrates a peak conversion gain of 0.7 dB and the maximum output power higher than 4 dBm at an output frequency of 84 GHz with the conversion efficiency of 14%.
Gas phase chemiluminescence of arsine mixed with ozone (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGas phase chemiluminescence of arsine mixed with ozoneMark E. Fraser, Donald H. Stedman, and Michael J. HendersonCite this: Anal. Chem. 1982, 54, 7, 1200–1201Publication Date (Print):June 1, 1982Publication History Published online1 May 2002Published inissue 1 June 1982https://pubs.acs.org/doi/10.1021/ac00244a044https://doi.org/10.1021/ac00244a044research-articleACS PublicationsRequest reuse permissionsArticle Views87Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Analysis and design of frame structures using non!linear models (2008)

Practitioner’s guide to finite element modelling of reinforced concrete structures (PDF) <i>fib</i> Bulletins N° 45. Practitioners' guide to finite element modelling of reinforced concrete structures. State-of-art report (344 pages, ISBN 978-2-88394-085-7, June 2008) - PDF format
Modified Purex first-cycle extraction for neptunium recovery (2008)

A new PUREX first-cycle flowsheet was devised to enhance the extraction yield of neptunium at the extraction step of this cycle. Simulation results (using a qualified process-simulation tool), le d to raising the nitric acid concentration of the feed from 3 M to 4.5 M to allow extraction of more than 99% of the neptunium. This flowsheet was operated in the shielded process cell of ATALANTE facility using pulsed columns and mixer-settlers banks. A 15 kg quantity of genuine oxide fuel of average burn up of 52 GWd/t with cooling time of nearly five years was treated, and the neptunium extraction yield obtained was greater than 99.6%. (authors)
SYNTHESIS OF 2′-C-METHYL-β-D-RIBOFURANOSYLIMIDAZO[4,5-D]PYRIDAZINE DERIVATIVES (2-AZA-3-DEAZAPURINE NUCLEOSIDE ANALOGUES) (2005)

In order to evaluate their antiviral properties, two imidazo[4,5-d]pyridazine 2'-C-methyl-beta-D-ribofuranonucleoside derivatives have been synthesized.
Autonomic management of client concurrency in a distributed storage service (2011)

A distributed autonomic system adapts its constituent components to a changing environment. This paper reports on the application of autonomic management to a distributed storage service. We developed a simple analytic model which suggested potential benefit from tuning the degree of concurrency used in data retrieval operations, to suit dynamic conditions. We then validated this experimentally by developing an autonomic manager to control the degree of concurrency. We compared the resulting data retrieval performance with non-autonomic versions, using various combinations of network capacity, membership churn and workload patterns. Overall, autonomic management yielded improved retrieval performance. It also produced a distinct but not significant increase in network usage relative to one non-autonomic configuration, and a significant reduction relative to another.
GaN photonic-crystal surface-emitting laser operating at blue-violet wavelengths (2008)

We report on a first successful operation of current-driven GaN photonic-crystal surface-emitting laser, which can operate in blue-violet wavelength regions at room temperature.
Antioxidant Activity of Knotwood Extractives and Phenolic Compounds of Selected Tree Species (2003)

The antioxidant potency and the radical scavenging capacity of superoxide and peroxyl radicals were assessed for 13 hydrophilic knotwood extracts of commercially important wood species, or fractions thereof, as well as for five pure wood-derived lignans and the flavonoid taxifolin. The chemical composition of the knotwood extracts was determined by gas chromatography combined with mass spectrometry. Most of the investigated wood species were rich in hydrophilic extractives (10-20% of the dry wood) with one or a few compounds dominating in each extract. All extracts had a high antioxidative potency and/or radical scavenging capacity as compared to the well-known antioxidants Trolox and butylated hydroxyanisole. The pure wood-derived lignans and taxifolin also had a high antioxidative potency and/or radical scavenging capacity. However, the antioxidant potency and/or radical scavenging capacity of several of the hydrophilic knotwood extracts were higher than that of the dominating compounds in pure form.
Yeast cell death pathway requiring AP-3 vesicle trafficking leads to vacuole/lysosome membrane permeabilization (2022)

Unicellular eukaryotes have been suggested as undergoing self-inflicted destruction. However, molecular details are sparse compared with the mechanisms of programmed/regulated cell death known for human cells and animal models. Here, we report a molecular cell death pathway in Saccharomyces cerevisiae leading to vacuole/lysosome membrane permeabilization. Following a transient cell death stimulus, yeast cells die slowly over several hours, consistent with an ongoing molecular dying process. A genome-wide screen for death-promoting factors identified all subunits of the AP-3 complex, a vesicle trafficking adapter known to transport and install newly synthesized proteins on the vacuole/lysosome membrane. To promote cell death, AP-3 requires its Arf1-GTPase-dependent vesicle trafficking function and the kinase Yck3, which is selectively transported to the vacuole membrane by AP-3. Video microscopy revealed a sequence of events where vacuole permeability precedes the loss of plasma membrane integrity. AP-3-dependent death appears to be conserved in the human pathogenic yeast Cryptococcus neoformans.
Comparison of the vacuum-ultraviolet radiation response of HfO2∕SiO2∕Si dielectric stacks with SiO2∕Si (2007)

Vacuum ultraviolet (vuv) emitted during plasma processing degrades dielectrics by generating electron-hole pairs. VUV-induced charging of SiO2∕p-Si and HfO2∕SiO2∕p-Si dielectric stacks are compared. For SiO2∕p-Si, charging is observed for photon energies &amp;gt;15eV by ionization of dielectric atoms from photoinjected electrons. In HfO2∕SiO2∕p-Si, charging is observed for photon &amp;gt;10eV and is due to ionization by photoinjected electrons and by H+ trapping in the HfO2∕SiO2 bulk. Hydrogen appears during annealing at the Si–SiO2 interface forming Si–H, which, during irradiation, is depassivated by photoinjected electrons. The authors conclude that dielectric charging in thin oxides (&amp;lt;10nm) occurs more easily in HfO2∕SiO2 than in SiO2.
Multi-branch neural network for hybrid metrology improvement (2022)

In the domain of advanced patterning, and especially at lithography steps achieve very small sizes becomes more and more crucial. This induces measurement challenges and thus requiring the development of new, precise and robust metrology techniques. To overcome the limited constraints of different techniques, one of the most promising approaches is hybrid metrology. It consists in gathering several metrology techniques to measure all the geometrical parameters which are processed them by an algorithm (mainly machine learning algorithm). This work stands out by using for deep learning a multi-branch neural network to increase the precision of predicts. With a particular attention made to the dataset generation and specific settings for each branch, we developed the potential of this approach which increase the precision of predicts.
Metal Supported on Dendronized Magnetic Nanoparticles:  Highly Selective Hydroformylation Catalysts (2006)

A method for homogenizing heterogeneous catalyst is described. The method is based on growing polyaminoamido (PAMAM) dendrons on silica-coated magnetic nanoparticles. After the dendronizing process, the silica-coated magnetic nanoparticles are more stable and more soluble in organic solvents. The dendronized particles are phosphonated, complexed with [Rh(COD)Cl]2, and applied in catalytic hydroformylation reactions. These new catalysts are proven to be highly selective and reactive.
Adjuvant activity of mycobacterial fractions: adjuvant activity of synthetic N-acetylmuramyl-dipeptide and the related compounds (1976)

Immunological activity of synthetic cell wall peptidoglycan subunits was examined in guinea pigs and mice. It was concluded that the minimal adjuvant-active subunit of cell wall peptidoglycan for the induction of delayed-type hypersensitivity to monoazobenzenearsonate-N-acetyl-L-tyrosine and for circulating-antibody formation to bacterial alpha-amylase and the thymus-independent antigen DNP-Ficoll was N-acetylmuramyldipeptide, MurNAc-L-Ala-D-isoGln. N-acetylmuramyldipeptide and 6-O-stearoyl-N-acetylmuramyldipeptide showed no adjuvant activity in the generation of cell-mediated cytotoxic effector cells in the spleens of C57Bl/6J mice after in vivo immunization with the allogeneic antigen mastocytoma P815-X2 cells, but N-acetylmuramyldipeptide showed adjuvant activity after in vitro sensitization of C57Bl/6J mouse spleen cells to the alloantigen mitomycin C-treated DBA/2 mouse spleen cells. It was also shown that 6-O-stearoylation of N-acetylmuramylpeptide could not potentiate the adjuvant activity of N-acetylmuramyldipeptide. Mitogenic and antitumor activities were not observed in either N-acetylmuramyldipeptide or 6-O-stearoyl-N-acetylmuramyldipeptide in mouse systems.
Predictive Measures of Locomotor Performance on an Unstable Walking Surface (2016)

Locomotion requires integration of visual, vestibular, and somatosensory information to produce the appropriate motor output to control movement. The degree to which these sensory inputs are weighted and reorganized in discordant sensory environments varies by individual and may be predictive of the ability to adapt to novel environments. The goals of this project are to: 1) develop a set of predictive measures capable of identifying individual differences in sensorimotor adaptability, and 2) use this information to inform the design of training countermeasures designed to enhance the ability of astronauts to adapt to gravitational transitions improving balance and locomotor performance after a Mars landing and enhancing egress capability after a landing on Earth.
Hardware-In-the-Loop Simulations Used as a Cost Efficient Tool for Developing an Advanced Stick-Slip Prevention System (2010)

Abstract Hardware-In-the-Loop (HIL) simulation is a technique where machine control software runs virtual machines, which are mathematical models emulating the physical machines. The technique has become increasingly popular in recent years, because of its ability to shorten product development time for complex dynamic systems, through quick and cost efficient testing over a wide range of conditions. This paper focuses on the lessons learned from HIL simulation testing of an advanced and patent applied method for curing and preventing stick-slip oscillations in drilling. In this project the HIL simulations have provided several advantages, such as a high repeatability in test conditions, the ability to test under challenging conditions rarely occurring in the field, thus avoiding time consuming field tests. The HIL simulations have also proven to be an efficient tool for debugging the control software, because programming errors are discovered long before the commissioning and field test phases. The HIL simulation of stick-slip oscillations uses an advanced dynamic model for the entire rotary system, including the top drive electronics, the motors, and the drillstring. The drillstring is modeled as a series of lumped inertia and torsional spring elements where the friction torque for each element is a non-linear function of the wellbore contact force and instant rotation speed. The lowest element also includes the bit torque as a function of weight on bit. The first version of a stick-slip prevention system, which has been described in an earlier IADC/SPE paper, was HIL tested over a wide range of drillstring and well geometries. Simulations with very long strings (typically 5000 m or longer) revealed that higher mode stick-slip oscillations tend to appear when the normal stick-slip oscillations are cured. The second mode frequency is roughly three times the frequency of the fundamental mode so it falls outside the effective absorption band for the first version prevention software. However, after adding an inertia compensating term in the tuned speed controller, the stick-slip prevention software was able to prevent both the fundamental and the higher modes stick-slip oscillations at the same time. In summary, the HIL simulations improved the stick-slip prevention system so it is more robust, easier to operate and has improved performance. The HIL simulations also helped to find and eliminate code bugs.
ChemInform Abstract: Zirconocene‐Mediated Carbonylative Coupling of Grignard Reagents. (2016)

Abstract The transmetalation of Grignard reagents with zirconocene dichloride under a CO atmosphere generates acyl zirconium(IV) complexes that are inaccessible with the Schwartz reagent, including those derived from secondary and tertiary alkyl and aryl Grignard reagents.
Pituitary Imaging Abnormalities and Related Endocrine Disorders in Erdheim–Chester Disease (2021)

We noted a high burden of API and endocrinopathies in ECD. API was highly associated with the presence of panhypopituitarism and DI. Therefore, a thorough assessment of hypothalamic-pituitary integrity should be considered in subjects with ECD.
Response times to conceptual questions (2013)

We measured the time taken by students to respond to individual Force Concept Inventory (FCI) questions. We examine response time differences between correct and incorrect answers, both before and after instruction. We also determine the relation between response time and expressed confidence. Our data reveal three results of interest. First, response times are longer for incorrect answers than for correct ones, indicating that distractors are not automatic choices. Second, response times increase after instruction for both correct and incorrect answers, supporting the notion that instruction changes students' approach to conceptual questions. Third, response times are inversely related to students' expressed confidence; the lower their confidence, the longer it takes to respond.
Immuno-PET Quantitation of de2-7 Epidermal Growth Factor Receptor Expression in Glioma Using 124I-IMP-R4–Labeled Antibody ch806 (2010)

These results show that immuno-PET with (124)I-IMP-R4-ch806 is feasible and allows noninvasive quantitation of de2-7 EGFR expression in vivo.
A influência da ionosfera no posicionamento GPS por ponto simples (2016)

\n A determinação das coordenadas de um ponto através do sistema GPS pode ser feita utilizando-se os métodos de posicionamento por ponto simples ou de posicionamento diferencial. No caso do posicionamento diferencial, devido à escassez de marcos geodésicos no território nacional, as linhas de base são em sua maioria extensas. Nessas duas situações os usuários de receptores de simples freqüência ficam sujeitos à utilização de modelos ionosféricos para estimativa da influência da ionosfera nos sinais e conseqüentemente na precisão da posição de pontos. Sendo assim, a escolha adequada de tal modelo vem a ser um importante fator a ser considerado durante o processamento dos dados. Neste trabalho foi feita a comparação de resultados de processamento de dados GPS obtidos com a utilização de diferentes modelos ionosféricos a partir de posicionamento por ponto simples, verificando a eficácia de cada um deles em função da latitude do ponto, da atividade solar e do horário do dia, a fim de determinar qual modelo é mais eficiente em cada situação. Para isto foi desenvolvido um programa para posicionamento por ponto simples em linguagem Visual Basic versão 5.0.\n
Epidemiology of Pertussis Among Young Pakistani Infants: A Community-Based Prospective Surveillance Study (2016)

In one of the first prospective surveillance studies of infant pertussis in a developing country, we identified a moderate burden of pertussis disease in early infancy in Pakistan.