gebhart/patrepeval huggingface dataset:
Abstract 156: Screening and characterization of inhibitors of G-protein coupled receptor kinase GRK6 as potential therapeutics for multiple myeloma (2012)

Abstract Multiple myeloma (MM) is one of the most common hematological malignancies, but current therapy options are limited to high-dose chemotherapy or high-risk stem-cell transplantation. It is clear that the development of more selective and less toxic treatments for MM is greatly needed. In a recent kinome-wide RNAi study by Tiedemann and colleagues (2010), the G-protein coupled receptor kinase-6 (GRK6) was identified as a critical kinase required for survival of MM cells. This study also suggests that MM cells, but not other cell types, are dependent on GRK6; and that gene silencing by shRNA or siRNA of GRK6, but not other GRKs, results in decreased survival. At present, the G-protein coupled receptor (GPCR) signaling mediated by GRK6 in MM cells is not well understood. Our current research aims to identify the important GPCRs phosphorylated by GRK6 and the signaling proteins/pathways implicated in survival of multiple myeloma cells. Through gene silencing techniques and expression of either the wild-type or kinase-dead form of GRK6 protein, we have determined that a functional GRK6 kinase domain is required for survival of MM cells. We have also demonstrated that the signaling pathway downstream of CXCR4 phosphorylation by GRK6 is defective in cells expressing the kinase-dead GRK6-mutant protein. This loss of signaling by the GRK6-mutant protein was observed for other GPCRs found to be important for survival of MM cells. These findings helped to validate that the kinase domain of GRK6 is a potential target for MM, and spurred the identification of small molecule kinase inhibitors of GRK6. Compounds with high potency in preliminary biochemical assays were screened against MM and non-MM cell lines to evaluate their activity and specificity in vivo. Small molecule inhibition of GRK6 kinase activity is a novel approach to the treatment of MM, as it specifically targets a protein found to be critical for survival of these cells through an unbiased RNAi study. Treatment options for patients with MM are limited and based on our preliminary findings small molecule inhibitors of GRK6 offer an alternative therapeutic approach to the treatment of MM. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 156. doi:1538-7445.AM2012-156
Figure S3 from Aquaporin-7 Regulates the Response to Cellular Stress in Breast Cancer (2023)

&lt;p&gt;Aquaporin-7 is required for breast tumor burden, metastasis, and metabolic reprogramming.&lt;/p&gt;
Multi-Agent Based Control of a Heterogeneous System (2006)

In this study, the Coordinated Hybrid Agent (CHA) framework for the control of Multi-Agent Systems (MASs) is applied for a heterogeneous multi-agent system. The system consists of a mobile robot, an overhead crane, and a robot manipulator. The final goal for this project is to implement coordination tasks for the system. In this framework, the control of the MAS is regarded as a decentralized control and coordination of agents. A coordination rule base is developed for the intelligent coordination control layer. Experiments show that the framework is able to model the heterogeneous multi-agent systems.
Detection of Glottal Closure Instants From Speech Signals: A Quantitative Review (2011)

The pseudo-periodicity of voiced speech can be exploited in several speech processing applications. This requires however that the precise locations of the glottal closure instants (GCIs) are available. The focus of this paper is the evaluation of automatic methods for the detection of GCIs directly from the speech waveform. Five state-of-the-art GCI detection algorithms are compared using six different databases with contemporaneous electroglottographic recordings as ground truth, and containing many hours of speech by multiple speakers. The five techniques compared are the Hilbert Envelope-based detection (HE), the Zero Frequency Resonator-based method (ZFR), the Dynamic Programming Phase Slope Algorithm (DYPSA), the Speech Event Detection using the Residual Excitation And a Mean-based Signal (SEDREAMS) and the Yet Another GCI Algorithm (YAGA). The efficacy of these methods is first evaluated on clean speech, both in terms of reliabililty and accuracy. Their robustness to additive noise and to reverberation is also assessed. A further contribution of the paper is the evaluation of their performance on a concrete application of speech processing: the causal-anticausal decomposition of speech. It is shown that for clean speech, SEDREAMS and YAGA are the best performing techniques, both in terms of identification rate and accuracy. ZFR and SEDREAMS also show a superior robustness to additive noise and reverberation.
Effect of In-Doping on the Properties of as-Grown p-Type GaN Grown by Metalorganic Vapour Phase Epitaxy (2002)

As-grown p-GaN was characterized using Hall measurement and X-ray diffraction analysis mainly at room temperature. All samples were grown by metalorganic vapour phase epitaxy. p-type GaN was grown using Cp2Mg as a dopant and In-doping during the GaN growth. Only using In-doping, GaN–Mg was activated at room temperature even without a thermal annealing process. A hole concentration of as high as 5 × 1017 cm—3 was achieved. As a whole trend, decreasing the biaxial strain and the twist in as-grown p-GaN resulted in an increase of the hole concentration.
Abstract 14479: Association Between Chest Compressions and Ventricular Fibrillation Recurrences in Successfully Shocked Out-Of-Hospital Cardiac Arrests (2016)

Introduction: Chest compressions (CC) are unquestioned as appropriate and beneficial during rescuing attempts of out-of-hospital cardiac arrest (OOHCA). However, adverse consequences from CC are well documented and CC share many aspects with commotio cordis, a well-known cause of VF induction. Hypothesis: To test the association between CC and VF recurrences (VFr) after a successful shock in OOHCA. Methods: The Progetto Vita database, prospectively collecting data on all resuscitation efforts in the Piacenza province (Italy), was used for the present analysis. All data concerning the resuscitation were prospectively collected according to the Utstein recommendations. From the 461 OOHCA found in a shockable rhythm, only those with both good ECG tracings and good quality audio recordings (160) were included in the analysis. VFr was defined as related to CC when the onset of VFr occurred during the actual CC artifact or immediately after. Otherwise, it was defined as spontaneous. The conduct of CC was confir...
Satellite-based remote sensing data set of global surface water storage change from 1992 to 2018 (2020)

Abstract. The recent availability of freely and openly available satellite remote sensing products has enabled the implementation of global surface water monitoring at a level not previously possible. Here we present a global set of satellite-derived time series of surface water storage variations for lakes and reservoirs for a period that covers the satellite altimetry era. Our goals are to promote the use of satellite-derived products for the study of large inland water bodies and to set the stage for the expected availability of products from the Surface Water and Ocean Topography (SWOT) mission, which will vastly expand the spatial coverage of such products, expected from 2021 on. Our general strategy is to estimate global surface water storage changes (ΔV) in large lakes and reservoirs using a combination of paired water surface elevation (WSE) and water surface area (WSA) extent products. Specifically, we use data produced by multiple satellite altimetry missions (TOPEX/Poseidon, Jason-1, Jason-2, Jason-3, and Envisat) from 1992 on, with surface extent estimated from Terra/Aqua Moderate Resolution Imaging Spectroradiometer (MODIS) from 2000 on. We leverage relationships between elevation and surface area (i.e., hypsometry) to produce estimates of ΔV even during periods when either of the variables was not available. This approach is successful provided that there are strong relationships between the two variables during an overlapping period. Our target is to produce time series of ΔV as well as of WSE and WSA for a set of 347 lakes and reservoirs globally for the 1992–2018 period. The data sets presented and their respective algorithm theoretical basis documents are publicly available and distributed via the Physical Oceanography Distributed Active Archive Center (PO DAAC; https://podaac.jpl.nasa.gov/, last access: 13 May 2020) of NASA's Jet Propulsion Laboratory. Specifically, the WSE data set is available at https://doi.org/10.5067/UCLRS-GREV2 (Birkett et al., 2019), the WSA data set is available at https://doi.org/10.5067/UCLRS-AREV2 (Khandelwal and Kumar, 2019), and the ΔV data set is available at https://doi.org/10.5067/UCLRS-STOV2 (Tortini et al., 2019). The records we describe represent the most complete global surface water time series available from the launch of TOPEX/Poseidon in 1992 (beginning of the satellite altimetry era) to the near present. The production of long-term, consistent, and calibrated records of surface water cycle variables such as in the data set presented here is of fundamental importance to baseline future SWOT products.
Crybb2 coding for βB2-crystallin affects sensorimotor gating and hippocampal function (2013)

βB2-crystallin (gene symbol: Crybb2/CRYBB2) was first described as a structural protein of the ocular lens. This gene, however, is also expressed in several regions of the mammalian brain, although its function in this organ remains entirely unknown. To unravel some aspects of its function in the brain, we combined behavioral, neuroanatomical, and physiological analyses in a novel Crybb2 mouse mutant, O377. Behavioral tests with male O377 mutants revealed altered sensorimotor gating, suggesting modified neuronal functions. Since these mouse mutants also displayed reduced hippocampal size, we concentrated further investigations on the hippocampus. Free intracellular Ca(2+) levels were increased and apoptosis was enhanced in the hippocampus of O377 mutants. Moreover, the expression of the gene encoding calpain 3 (gene symbol Capn3) was elevated and the expression of genes coding for the NMDA receptor subunits was downregulated. Additionally, the number of parvalbumin-positive interneurons was decreased in the hippocampus but not in the cortex of the mutants. High-speed voltage-sensitive dye imaging demonstrated an increased translation of input-to-output neuronal activity in the dentate gyrus of this Crybb2 mutant. These results point to an important function of βB2-crystallin in the hippocampal network. They indicate pleiotropic effects of mutations in the Crybb2 gene, which previously had been considered to be specific to the ocular lens. Moreover, our results are the first to demonstrate that βB2-crystallin has a role in hippocampal function and behavioral phenotypes. This model can now be further explored by future experiments.
Glucose-Derived Palladium(0) Nanoparticles as in Situ-Formed Catalysts for Suzuki–Miyaura Cross-Coupling Reactions in Isopropanol (2013)

Effective and convenient protocols using renewable sugar-derived palladium(0) nanoparticles (PdNPs) as in situ-formed catalysts for Suzuki–Miyaura cross-coupling reactions in isopropanol under thermal and microwave heating conditions have been developed. The addition of a small amount of glucose (5 mol %) to the reaction mixture lead to an increase in yield of the cross-coupled products compared to control experiments that omitted glucose. The size and morphology of the in situ-formed PdNPs were determined by TEM, and further EF-TEM analysis showed a hydrophilic hydroxylated shell around the individual palladium particles. The polar/hydrophilic nature of the nanoparticles allowed for their facile removal from the cross-coupled product, and a significant decrease in the amount of palladium incorporated into the final product was observed, as measured by ICP-MS analysis.
Design and experimental verification of passive microwave components and circuits using a 0.18 /spl mu/m FDSOI process (2005)

Integrated passive components and circuits were designed, fabricated and tested on MIT Lincoln Laboratory's fully depleted silicon on insulator (FDSOI) technology. Design, modeling, and experimental testing of the interdigitated capacitors (IDCs), and lumped element bandpass filters (BPFs) are reported in this paper. The IDCs were tested up to 10 GHz. The measured IDCs showed good agreement with the modeled IDC. A bandpass filter MMIC was designed for a center frequency of 3.275 GHz and a bandwidth of 1 GHz. The insertion loss of the BPFs ranges from 8.9 dB to 10 dB at the center frequency of the passband. The higher insertion loss of the filter was attributed to lower Q of the LC resonators at S-band frequencies. As far as the authors know, this is the first study on lumped element bandpass filters based on CMOS FDSOI technology.
Der DNA-Index als valider prognostischer Marker beim biliopankreatischen Karzinom: Ergebnisse von drei Langzeitstudien zu den Entitäten Pankreaskarzinom, intrahepatisches Gallengangskarzinom und hiläres Gallengangskarzinom (2015)

Die Prognose von Patienten mit malignen Erkrankungen des biliopankreatischen Systems ist heute weiterhin schlecht. Die Identifikation von Hochrisikopatienten sowie von Patienten mit besonders günstiger Prognose durch valide Prognosefaktoren ist daher von immenser Bedeutung. Die DNA-Ploidie stellt möglicherweise einen sinnvollen prognostischen Marker für diese Tumorentitäten dar, wobei aussagekräftige Studien hierzu bisher nicht vorliegen. Ziel der vorliegenden Studien sollte es daher sein, am eigenen Patientenkollektiv die prädiktive Wertigkeit des DNA-Index für Patienten mit biliopankreatischem Karzinom zu evaluieren.
Limitations of reduced‐field irradiated volume and technique in conventional radiation therapy of prostate cancer: Implications for conformal 3D treatment (2000)

In order to define technical limitations of conventional external beam irradiation for clinically localized prostate cancer, we evaluated the impact of several reducedfield treatment factors, such as reduced-field (RF) irradiated volume, RF technique, photon energy of treatment, and dose on survival endpoints and local control in a retrospective series. Several survival endpoints, such as disease-specific survival, freedom from relapse survival, biochemical no-evidence of disease (bNED) survival, and local control were associated with several treatment variables using univariate and multivariate analyses in 329 patients. Reduced-field technique appeared to predict survival outcome, with patients treated by bilateral 120arcs faring less well than those treated by full 360rotational fields. The irradiated volume of the reduced-field was also significantly associated with survival outcome, with patients treated with smaller volumes faring less well. Local failure rates also appeared increased, although not statistically, in patients treated with smaller RF sizes. In an attempt to explain these detected deficiencies, dose-volume histograms for prostate coverage were created for a small sample of patients. The deficiencies related to small reduced-field volume appeared to be largely attributable to poor dosimetric coverage of the prostate. These results underscore the limitations of conventional external beam treatment for prostate carcinoma when conventional techniques are employed, particularly if small reduced fields are used, and further supports the development of improved treatment techniques, such as conformal irradiation, as alternatives.
Resource management of enterprise cloud systems using layered queuing and historical performance models (2010)

The automatic allocation of enterprise workload to resources can be enhanced by being able to make `what-if' response time predictions, whilst different allocations are being considered. It is important to quantitatively compare the effectiveness of different prediction techniques for use in cloud infrastructures. To help make the comparison of relevance to a wide range of possible cloud environments it is useful to consider the following. 1.) urgent cloud customers such as the emergency services that can demand cloud resources at short notice (e.g. for our FireGrid emergency response software). 2.) dynamic enterprise systems, that must rapidly adapt to frequent changes in workload, system configuration and/or available cloud servers. 3.) The use of the predictions in a coordinated manner by both the cloud infrastructure and cloud customer management systems. 4.) A broad range of criteria for evaluating each technique. However, there have been no previous comparisons meeting these requirements. This paper, meeting the above requirements, quantitatively compares the layered queuing and (¿HYDRA¿) historical techniques - including our initial thoughts on how they could be combined. Supporting results and experiments include the following: i.) defining, investigating and hence providing guidelines on the use of a historical and layered queuing model; ii.) using these guidelines showing that both techniques can make low overhead and typically over 70% accurate predictions, for new server architectures for which only a small number of benchmarks have been run; and iii.) defining and investigating tuning a prediction-based cloud workload and resource management algorithm.
Extended depth-of-field microscopy (2010)

In this paper, we present details of a scanning two-photon fluorescence microscope we have built with a nearisotropic scan rate. This means that the focal spot can be scanned at high speed along any direction in the specimen, without introducing systematic aberrations. We present experimental point spread function measurements for this system using an Olympus 1.4 NA 60X oil immersion lens that demonstrates an axial range of operation greater than 70 &mu;m. We give details of a novel actuator device used to displace the focusing element and demonstrate axial scan responses up to 3.5 kHz. Finally, we present an application of this system in liquid crystal research to image the dynamic response of a nematic device during switching. Information about the director field at different levels in the device can be inferred from images acquired with a temporal resolution of 2.5 ms.
Peroxidasin is essential for endothelial cell survival and growth signaling by sulfilimine crosslink‐dependent matrix assembly (2020)

Peroxidasin (PXDN) has been reported to crosslink the C-terminal non-collagenous domains of collagen IV (Col IV) by forming covalent sulfilimine bond. Here, we explored the physiological role of PXDN and its mechanism of action in endothelial cell survival and growth. Silencing of PXDN using siRNAs decreased cell proliferation without increase of the number of detached cells and decreased cell viability under serum-starved condition with increased fragmented nuclei and caspase 3/7 activity. Conditioned medium (CM) containing wild-type PXDN restored the proliferation of PXDN-depleted cells, but CM containing mutant PXDN with deletion of either N-terminal extracellular matrix (ECM) motifs or peroxidase domain failed to restore PXDN function. Accordingly, anti-PXDN antibody [raised against IgC2 (3-4) subdomain within ECM motifs] and peroxidase inhibitor phloroglucinol prevented the rescue of the PXDN-depleted cells by PXDN-containing CM. PXDN depletion resulted in loss of sulfilimine crosslinks, and decreased dense fibrillar network assembly of not only Col IV, but also fibronectin and laminin like in Col IV knockdown. Exogenous PXDN-containing CM restored ECM assembly as well as proliferation of PXDN-depleted cells. Accordingly, purified recombinant PXDN protein restored the proliferation and ECM assembly, and prevented cell death of the PXDN-depleted cells. PXDN depletion also showed reduced growth factors-induced phosphorylation of FAK and ERK1/2. In addition, siPXDN-transfected cell-derived matrix failed to provide full ECM-mediated activation of FAK and ERK1/2. These results indicate that both the ECM motifs and peroxidase activity are essential for the cellular function of PXDN and that PXDN is crucial for ECM assembly for survival and growth signaling.
Energy efficiency and color quality limits in artificial light sources emulating natural illumination (2014)

We present in this work a calculation of the theoretical limits attainable for natural light emulation with regard to the joint optimization of the Luminous Efficacy of Radiation and color fidelity by using multiple reflectance spectra datasets, along with an implementation of a physical device that approaches these limits. A reduced visible spectrum of blackbody radiators is introduced and demonstrated which allows lamps designed to emulate natural light to operate with excellent color fidelity and higher efficiency as compared to full visible spectrum sources. It is shown that even though 3,000K and 5,500K blackbody sources have maximum efficacies of 21 lm/W and 89 lm/W, respectively, reduced-spectrum artificial light sources can exceed those values up to 363 lm/W and 313 lm/W, respectively, while retaining excellent color fidelity. Experimental demonstration approaching these values is accomplished through the design and implementation of a 12-channel light engine which emits arbitrarily-tunable spectra. The color fidelity of the designed spectra is assessed through Color Rendering Maps, showing that color fidelity is preserved uniformly over a large spectral reflectance dataset, unlike other approaches to generate white light.
Copper Chloro-Complexes Concentrated Solutions: An Electrochemical Study (2021)

Basic studies on concentrated solutions are becoming more and more important due to the practical industrial and geological applications. The use in redox flow batteries is one of the most important applications of these solutions. Specifically, in this paper we investigated high-concentrated copper chloro-complexes solutions with different additives. The concentration of ligands and additives affects the physicochemical and electrochemical properties of 2 M solutions of Cu(I) and Cu(II). Solutions with calcium chloride and HCl as Cl− source were investigated with Cu:Cl ratios of 1:5 and 1:7, the 1:5 Cu:Cl ratio being the best performing. The substitution of calcium chloride with ammonium chloride increased the conductivity. However, while the effect on the positive electrode process was not very evident, the reversibility of the copper deposition–stripping process was greatly improved. Orthophosphoric acid could be a viable additive to decrease the complexation of calcium with chloride anions and to improve the stability of Cu(II) chloro-complexes. Absorption spectroscopy demonstrated that phosphate ions do not coordinate copper(II) but lead to a shift in the distribution of copper chloro-complexes toward more coordinated species. Electrochemically, the increased availability of chloride anions in solution stabilized the Cu(II)-rich solution and led to increased reversibility of the Cu(II)/Cu(I) redox process.