gebhart/patrepeval huggingface dataset:
Correction for piezoelectric creep in scanning probe microscopy images using polynomial mapping (2003)

We describe a method for using polynomial mapping to correct scanning probe microscope images for distortion due to piezoelectric creep. Because such distortion varies from image to image, this method can be used when the actual locations of some features within an image are known absolutely, or in a series of images in which the actual locations of some features are known not to vary. While the general case of polynomial mapping of degree N requires the determination of 2(N+ 1)2 matrix elements by regression, we find that by understanding the mechanism by which piezoelectric creep distorts scanning probe microscope images, we can fix most of these coefficients at 0 or 1 a priori, leaving only 2(N+ 1) coefficients to be determined by regression. We describe our implementation of this strategy using the Interactive Data Language (IDL) programming language, and demonstrate our technique on a series of atomic force microscopy (AFM) images of diblock copolymer microdomains. Using our simplified scheme, we are able to reduce the effects of distortion in an AFM image from 5% of the scan width to a single pixel, using only five reference points.
15.2: Green Laser Sequential Lateral Solidification G‐SLS Process for AMOLED Applications (2011)

Abstract This paper presents a novel green laser sequential lateral solidification G‐SLS process for AMOLED applications. G‐SLS utilizes a high frequency pulsed green laser and 2D mask patterns to manipulate the microstructure of crystallize Si films. Mask patterns have been optimized to obtain uniform microstructure of the crystallized Si films at the overlap region. Thin film transistors based on G‐SLS processed Si films have mobility of 150.72 cm 2 /V‐sec and a sub‐threshold swing of 0.20V/dec. 14″ qFHD AMOLEDs have been fabricated using the G‐SLS process. The advantages and issues of G‐SLS technology will be further discussed.
System-level SoC near-field (NF) emissions: Simulation to measurement correlation (2012)

As System-on-Chip (SoC) designs migrate to 28nm process node and beyond, the electromagnetic (EM) co-interactions of the Chip-Package-Printed Circuit Board (PCB) becomes critical and require accurate and efficient characterization and verification. In this paper a fast, scalable, and parallelized boundary element based integral EM solutions to Maxwell equations is presented. The accuracy of the full-wave formulation, for complete EM characterization, has been validated on both canonical structures and real-world 3-D system (viz. Chip + Package + PCB). Good correlation between numerical simulation and measurement has been achieved. A few examples of the applicability of the formulation to high speed digital and analog serial interfaces on a 45nm SoC are also presented.
Hemostatic function in hyperfibrinolytic disseminated intravascular coagulation (2019)

The release of intravascular TF contributed to sustained activation of coagulation and subsequent fibrinolytic activity in this patient with AML-associated DIC, and T/P-GA could provide better quantitative data than conventional assays in these circumstances.
Efficient CMOS Invertible Logic Using Stochastic Computing (2019)

Invertible logic can operate in one of two modes: 1) a forward mode, in which inputs are presented and a single, correct output is produced, and 2) a reverse mode, in which the output is fixed and the inputs take on values consistent with the output. It is possible to create invertible logic using various Boltzmann machine configurations. Such systems have been shown to solve certain challenging problems quickly, such as factorization and combinatorial optimization. In this paper, we show that invertible logic can be implemented using simple spiking neural networks based on stochastic computing. We present a design methodology for invertible stochastic gates, which can be implemented using a small amount of CMOS hardware. We demonstrate that our design can not only correctly implement the basic gates with invertible capability but can also be extended to construct invertible stochastic adder and multiplier circuits. The experimental results are presented, which demonstrate the correct operation of synthesizable invertible circuitry performing both multiplication and factorization, along with fabricated ASIC measurement results for an invertible multiplier circuit.
Interictal Schizophrenia-like Psychosis in a Patient With Double Cortex Syndrome (2002)

The authors report a female patient with sporadic double cortex syndrome who manifested recurrent interictal schizophrenia-like psychoses. She had no mutations in the doublecortin gene but a pericentric inversion of chromosome 9. Neurodevelopmental disturbances and seizures may be associated with her mental dysfunction.
A Decomposition-Based RLS Algorithm for Stereophonic Acoustic Echo Cancellation (2022)

In hands-free teleconferencing systems, stereo transmission provides telepresence thanks to our binaural hearing system and gives a realistic presence that actual single-channel systems cannot offer. In this context, stereophonic acoustic echo cancellation (SAEC) is necessary for full-duplex quality communication. Nevertheless, the long length of the acoustic impulse responses represents one of the main challenges in SAEC, which significantly impacts the overall performance of the adaptive filters used to model the acoustic echo paths. In this paper, we propose a decomposition-based approach using the nearest Kronecker product, which results in a combination of shorter filters to solve the original system identification problem. The solution is formulated in terms of the recursive least-squares (RLS) algorithm, which is very appealing for its convergence features. Besides the lower computational complexity, the proposed decomposition-based RLS algorithm achieves a better tracking behavior as compared to its conventional counterpart. Simulation results support these practical features.
Prices and Portfolio Choices in Financial Markets: Theory and Experiment (2005)

Most tests of asset pricing models address only the pricing predictions — perhaps because the portfolio choice predictions are obviously wrong. But how can pricing theory be right if the portfolio choice theory on which it rests is wrong? This paper suggests an answer: the assumptions about individual preferences that underly common asset-pricing models are wrong, but the deviations between the demands predicted by these models and the true demands have mean zero in the population, and hence wash out in prices. The starting point for this work is a set of experimental markets in which risky and riskless assets are traded. This experimental setting offers an opportunity to study asset pricing in an environment in which crucial variables can be controlled or observed — in contrast to field environments, in which these variables cannot be controlled and frequently cannot be observed accurately. The experimental data exhibit the same puzzling characteristics as the historical data: asset prices are consistent with the price predictions of familiar theories (for instance, the market portfolio is nearly mean-variance efficient) but portfolio choices are wildly divergent from the portfolio choice predictions of the same theories (for instance, portfolio separation does not obtain). To explain the data, we build a structural model based on perturbations of individual demand functions (in the familiar style of much applied work). The central feature of this model is that the perturbations (i.e., the differences between individual demands and the demands predicted by mean-variance utility) have mean zero in the population. We develop an econometric test of the model which tests both prices and portfolio choices, and find that the empirical distribution of the test statistic is consistent with model predictions. JEL Classification Numbers C91, C92, D51, G11, G12
Decoding the Tissue of Origin of Cellular Damage from Cell-Free DNA in Liquid Biopsies (2020)

Liquid biopsy applications are rapidly emerging as a minimally invasive approach to collect system-wide representative analytes and provide information about cancer and other disease at the molecular level that may benefit clinical decision-making. Delineating the origins of circulating molecules is essential towards understanding their biological properties and providing potential clinical utility. Tissue-of-origin (TOO) deconvolution analysis can be used to trace cell-free nucleic acids (cfDNA) present in the circulation back to the tissues and cell-types they originated from. Also, functional information on tissues and cell types may be generated from the different layers of epigenomics analyses of cfDNA that include DNA methylation, nucleosome remodeling, and histone modifications. Here, we first summarize advances in liquid biopsy towards understanding the biology of various components present in the circulation with a focus on molecular oncology. We then review the computational methods that serve as the foundation for TOO analysis of cfDNA and highlight major contributions using this methodology. Finally, we discuss the applications of cfDNA TOO analysis and discuss opportunities and current limitations of the approach for clinical practice.
Porous Poly(Vinyl Alcohol)-Hydrogel Matrix-Engineered Biosynthetic Cartilage (2010)

The objective of this study was to fabricate hydrogel matrix-engineered biosynthetic cartilage using a porous poly(vinyl alcohol) hydrogel (PVA-H) and articular chondrocytes. Chondrocytes were suspended in fibrin gel (FG) or saline carriers and injected into porous PVA-H discs and three-layered constructs (PVA-H between devitalized cartilage). After implantation in nude mice, PVA discs were explanted at 6 weeks and subjected to creep testing for a 20 h period. The three-layered constructs were explanted at 12 weeks and subjected to tensile testing to determine the strength of the interface between the engineered hydrogel and devitalized cartilage. Histological analysis revealed PVA-H porous channels occupied by chondrocytes. Extracellular matrix was identified by Safranin-O and toluidine blue stains. Immunohistochemical analysis revealed a positive stain for COL II and scant staining for COL I. Creep and relaxation response of PVA-FG-chondrocyte constructs was similar to that of native cartilage. The presence of cells and FG significantly enhanced the integration strength of layered constructs (p < 0.05). These results demonstrate that porous PVA-H in combination with FG and chondrocytes provides a favorable microenvironment for tissue engineering of articular cartilage, creating a biosynthetic construct that can adhere to native devitalized articular cartilage utilizing hydrogel matrix-engineered technology.
The emergence of factor Xa inhibitors for the treatment of cardiovascular diseases: a patent review (2012)

A large body of Phase II and Phase III data is now available for FXa inhibitors such as rivaroxaban, apixaban, edoxaban and betrixaban. The clinical data demonstrate favorable benefit-risk profiles compared with the standards of care for short- and long-term anticoagulation (i.e., low molecular weight heparins (LMWHs) and wafarin). The potential exists that these agents will eventually be the agents of choice for the treatment of a host of cardiovascular disease states, offering improved efficacy, safety, and ease of use compared with existing anticoagulants.
T CELL RECOGNITION OF XENO-MHC PEPTIDES DURING CONCORDANT XENOGRAFT REJECTION1 (1996)

T cell recognition of xenoantigens is likely to play a key role in rejection of xenografts surviving hyperacute and delayed xenograft rejection, but the mechanisms of how this might occur are unknown. We used synthetic rat class II MHC peptides to study the role of the indirect pathway, where processed xenogeneic MHC antigens are presented in the context of self MHC, in a concordant xenograft rejection model in vivo. Mice of four different strains, BALB/c, B1O.A, CBA/ca, and C57BL/6j, were immunized with a mixture of rat class II MHC 25-mer xenopeptides representing the full-length sequence of the beta chain hypervariable domain of either RT1.Du (DR and I-E like) or RT1.Bu (DQ and I-A like) of the Wistar-Furth (WF) (RT1u) rat. Draining lymph node cells were capable of recognizing and proliferating to specific class II xeno-MHC peptides. The immunogenicity of the different peptides varied with the responder mouse strain. Responder T cells were CD4+, and were inhibited by anti-I-A and anti-I-E antibodies. We then examined the proliferative response of T cells from B1O.A primed by WF skin or vascularized cardiac xenografts to the class II MHC xenopeptides, when presented by naive B1O.A splenic antigen-presenting cells. These T cells were capable of proliferating to the same xeno-MHC peptides shown to be immunogenic by immunization. These data confirm the occurrence of self-restricted T cell recognition of xeno-MHC peptides in xenograft rejection, and provide the rationale for further investigating the role of the indirect pathway of recognition in xenotransplantation.
Electrodeposition of Arrays of Ru, Pt, and PtRu Alloy 1D Metallic Nanostructures (2010)

International audience
Quasi-ballistic phonon transport effects on the determination of the\n mean-free path accumulation function for the effective thermal conductivity (2015)

The mean-free path (MFP) accumulation function for the effective thermal\nconductivity, introduced by Dames and Chen is a compact, universal and highly\nuseful summary of the effect of ballistic thermal transport on the effective\nthermal conductivity measured by various experiments. The frequency domain\nthermoreflectance (FDTR) experiment is especially well suited to its\ndetermination. Extraction of the accumulation function from this experiment\nuses the thermal penetration depth (TPD) of phonons at each frequency as a\ncut-off for classifying phonons as ballistic or diffusive at that frequency. In\nthis paper, we show that using the TPD as a cut-off is arbitrary and prone to\nserious error. We report on a new technique to deduce the MFP accumulation\nfunction from the FDTR experiment by numerical solution of an enhanced Fourier\nlaw.\n
Studies on the mechanism for entry of vesicular stomatitis virus glycoprotein g mRNA into membrane-bound polyribosome complexes (1977)

Glycoprotein mRNA (G mRNA) of vesicular stomatitis virus is synthesized in the cytosol fraction of infected HeLa cells. Shortly after synthesis, this mRNA associates with 40S ribosomal subunits and subsequently forms 80S monosomes in the cytosol fraction. The bulk of labeled G mRNA is then found in polysomes associated with the membrane, without first appearing in the subunit or monomer pool of the membrane-bound fraction. Inhibition of the initiation of protein synthesis by pactamycin or muconomycin A blocks entry of newly synthesized G m RNA into membrane-bound polysomes. Under these circumstances, labeled G mRNA accumulates into the cytosol. Inhibition of the elongation of protein synthesis by cucloheximide, however, allows entry of 60 percent of newly synthesized G mRNA into membrane-bound polysomes. Furthermore, prelabeled G mRNA associated with membrane-bound polysomes is released from the membrane fraction in vivo by pactamycin or mucomycon A and in vitro by 1mM puromycin - 0.5 M KCI. This release is not due to nonspecific effects of the drugs. These results demonstrate that association of G mRNA with membrane-bound polysomes is dependent upon polysome formation and initiation of protein synthesis. Therefore, direct association of the 3' end of G mRNA with the membrane does not appear to be the initial event in the formation of membrane-bound polysomes.
Proton NMR study of the binding of bis(acridines) to d(AT)5.cntdot.d(AT)5. 2. Dynamic aspects (1985)

Measurements of the 1H NMR spectra and relaxation rates were used to study the dynamic properties of 9-aminoacridine (9AA) and four bis(acridine) complexes with d(AT)5.d(AT)5. The behavior of the 9AA (monointercalator) and that of C8 (bisintercalator containing an eight-carbon atom linker chain) are entirely similar. For both compounds, the lifetime of the drug in a particular binding site is 2-3 ms at approximately 20 degrees C, and neither affects the A.T base pair opening rates. The complex with C10 (bisintercalator containing a 10-carbon atom linker chain) is slightly more stable than the C8 complex since its estimated binding site lifetime is 5-10 ms at 29 degrees C. Base pairs adjacent to the bound C10 are destabilized, relative to free d(AT)5.d(AT)5, but other base pairs in the C10 complex are little affected. Bis(acridine) pyrazole (BAPY) and bis(acridine) spermine (BAS) considerably stabilize those base pairs that are sandwiched between the two acridine chromophores, but in the BAS complex proton exchange from the two flanking base pairs appears to be accelerated, relative to free d(AT)5.d(AT)5. The lifetime of these drugs in specific binding sites is too long (>10 ms) to be manifested in increased line widths, at least up to 41 degrees C. An important conclusion from this study is that certain bisintercalators rapidly migrate along DNA, despite having large binding constants (K>10(6) M-1). For C8 and C10 complexes, migration rates are little different from those deduced for 9AA. The rigid linker chain in BAPY and the charge interactions in BAS retard migration of these two bisintercalators. These results provide new parameters that are useful in understanding the biochemical and biological properties of these and other bisintercalating drugs.
Identification of Genes Encoding Secreted Proteins Using Mini-O phoA Mutagenesis (2003)

Protein fusions are invaluable tools for the genetic studies involving the mechanisms of protein export in bacteria. In 1985, Hoffman and Wright developed an in vitro fusion approach that allowed for fusions of the gene encoding Escherichia coli alkaline phosphatase to a variety of cloned genes (1). The modified phoA gene employed in these studies, designated 'phoA, resulted in the production of a highly active alkaline phosphatase protein missing its signal sequence (1). This approach is based on the fact that bacterial alkaline phosphatase is normally periplasmic and must be located extracytoplasmically to be active, i.e., export is essential for high levels of alkaline phosphatase activity (1). Through the fusion of 'phoA to portions of heterologous genes containing signal sequences, export from the cytoplasm and subsequent PhoA activity can be observed (1).
Escape Attempts (2003)

From sexual fantasies to holidays this marvellous book charts our escape attempts. In a series of dazzling commentaries the authors reveal the ordinary and extraordinary ways in which we seek to defy the despair of the breakfast table and the office But the book is much more than a first-rate cartography of everyday life. It crackles with important theoretical insights about how `normality' is managed. This fully revised edition contains a superb new introduction, `Life After Postmodernism', which exposes the conceits of the postmodernist adventure and which should be required reading for anyone interested in making sense of everyday life.
ENDOR Spectroscopic Evidence for the Geometry of Binding of retro-inverso-Nω-Nitroarginine-Containing Dipeptide Amides to Neuronal Nitric Oxide Synthase (2000)

We describe in detail the use of 35 GHz Mims pulsed 15N and 1,2H electron−nuclear double resonance (ENDOR) spectroscopy to study the binding of substrates and inhibitors to nitric oxide synthase (NOS). We show that reliable distance estimates, and limited orientation information, can be derived from a small set of data taken near the peak of the absorption mode EPR signal, while more precise orientations require a more extensive data set. The ENDOR approach is then applied to the binding of isoform-selective and non-selective nitroarginine inhibitors. Recently, we reported a family of Nω-nitroarginine-containing dipeptide amides as highly selective inhibitors of nNOS (Huang, H. et al. J. Med. Chem. 1999, 42, 3147−3153). Two of the most potent analogues were the retro-inverso-dipeptide amides l-ArgNO2-l-Lys-NH2 (LL) and d-Lys-d-ArgNO2−NH2 (DD). To rationalize the common selectivities of LL and DD, it was proposed that in both cases the nitroarginine group binds at the heme binding site, therefore requiring one of these molecules to undergo a 180° flip to accommodate such an interaction. The present studies confirm that the dipeptides indeed bind to holo-nNOS quite similarly from the point of view of the nitroguanidine functionality, supporting the earlier interpretation. The data further suggest that a substantial fraction of the DD epimer is distributed among other binding geometries.
ChemInform Abstract: Stereochemistry of the Dihydropyrone Diels—Alder Reaction. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Generation of single frequency highly coherent high-order Laguerre Gaussian modes with Vertical-External-Cavity-Surface-Emitting-Laser (2013)

Laser beams operating at high-order Laguerre-Gauss (LG) modes have lots of applications in many areas including laser drilling and writing, optical manipulation, trapping and guiding of atoms [1,2]. In fact, the LG modes are the natural modes for a linear cavity using spherical mirrors and having axial symmetry of revolution[3]. We demonstrated that the Vertical External Cavity Surface Emitting Laser (VECSEL) is a very promoting laser technology for the generation of this kind of light beams [4]. Indeed, the VeCSEL design relies on small thickness quantum-well (QW) gain medium which minimizes non-linear optical interactions, thermal effects and possible astigmatism inside the semiconductor structure. The interplay of this 2 (2D) dimensions transverse gain medium with a low-loss cavity design permits the generation of single frequency high quality diffraction limited beam profiles.
Unusual Tuning of Mechanical Properties of Thermoplastic Elastomers Using Supramolecular Fillers (2006)

Supramolecular fillers were incorporated in a poly(ε-caprolactone)-based polyurea in a modular approach via a “perfect-fit” principle. DSC and AFM studies both support the same model in which the bis(ureido)butylene-based filler molecules are incorporated into the bis(ureido)butylene hard segment domains of the polymer via bifurcated hydrogen-bonding interactions up to 23 mol % (= 7.3 wt %) of incorporated filler. Polymer hard segment and filler form a single phase, and the soft phase remains unaffected. This resulted in stiffer materials (23 mol % of incorporated filler more than doubled the Young's modulus) without a decrease in tensile strength or elongation at break. When more than 23 mol % of filler was added to the polyurea, separate filler crystallites were observed in both AFM and DSC. A drop in Young's modulus was now observed, followed by an increase upon adding even more filler. In this second regime, a decrease in tensile strength and elongation at break was observed, revealing similar behavior to reinforcing thermoplastic elastomers with the more common micrometer-sized reinforcement fillers.