gebhart/patrepeval huggingface dataset:
In-stroke word completion (2006)

We present the design and implementation of a word-level stroking system called Fisch, which is intended to improve the speed of character-level unistrokes. Importantly, Fisch does not alter the way in which character-level unistrokes are made, but allows users to gradually ramp up to word-level unistrokes by extending their letters in minimal ways. Fisch relies on in-stroke word completion, a flexible design for fluidly turning unistroke letters into whole words. Fisch can be memorized at the motor level since word completions always appear at the same positions relative to the strokes being made. Our design for Fisch is suitable for use with any unistroke alphabet. We have implemented Fisch for multiple versions of EdgeWrite, and results show that Fisch reduces the number of strokes during entry by 43.9% while increasing the rate of entry. An informal test of "record speed" with the stylus version resulted in 50-60 wpm with no uncorrected errors.
Design Decisions for Interactive Environments: Evaluating the KidsRoom (1998)

We believe the KidsRoom is the first multi-person, fully-automated, interactive, narrative environment ever constructed using non-encumbering sensors. The perceptual system that drives the KidsRoom is outlined elsewhere(Bobick et al. 1996). This paper describes our design goals, successes, and failures including sev-eral general observations that may be of interest to other designers of perceptually-based interactive en-vironments. I Introduction and Goals We are investigating the technologies required to build perceptually-based interactive and immersive spaces--spaces that respond to people’s actions in a real, physical space by augmenting the environment with graphics, video,
Comments on Plasmalemmal Vesicle Associated Protein-1 as a Novel Marker Implicated in Brain Tumor Angiogenesis (2006)

To the Editor: We have read with great interest the November 1, 2005 article by Carson-Walter et al. ([1][1]) on plasmalemmal vesicle–associated protein 1 (PV-1; also called PLVAP) expression in malignant brain. The authors have shown that PLVAP is expressed in a subset of malignant and diseased
Hippocampal subfield imaging and fractional anisotropy show parallel changes in Alzheimer's disease tau progression using simultaneous tau‐PET/MRI at 3T (2021)

This study demonstrates the potential for quantifiable patterns of <sup>18</sup>F-PI2620 binding in hippocampus subfields, accompanied by diffusion and volume metrics, to be valuable markers of AD.
Capacity scaling of wireless networks with complex field network coding (2009)

Network coding in wired networks has been shown to achieve considerable throughput gains relative to traditional routing networks. While the ergodic capacity of wireless multihop networks is unknown, the scaling of capacity with the number of nodes (n) has recently received increasing attention. While existing works mainly focus on networks with n source-destination pairs, this paper deals with capacity scaling in any-to-any wireless links, where each node communicates with all other nodes. Complex field network coding (CFNC) is adopted at the physical layer to allow n nodes exchanging information with simultaneous transmissions from multiple sources. A hierarchical CFNC-based scheme is developed and shown to achieve asymptotically (as n rarr infin) optimal quadratic capacity scaling in a dense network, where the area is fixed and the density of nodes increases. This is possible by dividing the network into many clusters, with each cluster sub-divided into many sub-clusters, hierarchically.
Synthesis and Evaluation of Dipeptide Amides Containing Nω-Nitroarginine and D-2, 4-Diaminobutyric Acids as Inhibitors of Neuronal Nitric Oxide Synthase (2001)

Selective inhibition of the isoforms of nitric oxide synthase (NOS) could be beneficial in the treatment of certain disease states arising from the overproduction of nitric oxide by NOS. Recently, we reported dipeptide amides containing a basic amine side chain as potent and selective inhibitors of neuronal NOS (Huang H. et al. (1999) J. Med. Chem., 42, 3147). The most potent nNOS inhibitor among these compounds is L-ArgNO2-L-Dbu-NH2 (1) (Ki = 130 nM), which also exhibits the highest selectivity over eNOS (> 1500-fold). The D,D-dipeptide, D-Lys-D-ArgNO2-NH2 (3) also shows high potency and selectivity. Here the dipeptide amides containing ArgNO2 and D-Dbu (9-12) were synthesized and evaluated. They are all modest inhibitors of nNOS, but poor inhibitors of eNOS and iNOS. D-Dbu-D-ArgNO2-NH2 (12) exhibits decreased inhibitory potency as compared with 3. A hypothesis regarding the binding at the active site of nNOS is proposed to explain the potency differences between the L- and D-form dipeptide amides.
Analysis of Injury Criteria to Assess Chest and Abdominal Injury Risks in Blunt and Ballistic Impacts (2004)

BC and VC are virtually identical in their ability to assess blunt and ballistic impact injury risks. They are different measures of impact energy absorbed by the body. One is predictive using input parameters, and the other measures the impact response of the body.
Calcium Binding and Transport by Coenzyme Q (2011)

Coenzyme Q10 (CoQ10) is one of the essential components of the mitochondrial electron-transport chain (ETC) with the primary function to transfer electrons along and protons across the inner mitochondrial membrane (IMM). The concomitant proton gradient across the IMM is essential for the process of oxidative phosphorylation and consequently ATP production. Cytochrome P450 (CYP450) monoxygenase enzymes are known to induce structural changes in a variety of compounds and are expressed in the IMM. However, it is unknown if CYP450 interacts with CoQ10 and how such an interaction would affect mitochondrial function. Using voltammetry, UV-vis spectrometry, electron paramagnetic resonance (EPR), nuclear magnetic resonance (NMR), fluorescence microscopy and high performance liquid chromatography-mass spectrometry (HPLC-MS), we show that both CoQ10 and its analogue CoQ1, when exposed to CYP450 or alkaline media, undergo structural changes through a complex reaction pathway and form quinone structures with distinct properties. Hereby, one or both methoxy groups at positions 2 and 3 on the quinone ring are replaced by hydroxyl groups in a time-dependent manner. In comparison with the native forms, the electrochemically reduced forms of the new hydroxylated CoQs have higher antioxidative potential and are also now able to bind and transport Ca(2+) across artificial biomimetic membranes. Our results open new perspectives on the physiological importance of CoQ10 and its analogues, not only as electron and proton transporters, but also as potential regulators of mitochondrial Ca(2+) and redox homeostasis.
A compile-time managed multi-level register file hierarchy (2011)

As processors increasingly become power limited, performance improvements will be achieved by rearchitecting systems with energy efficiency as the primary design constraint. While some of these optimizations will be hardware based, combined hardware and software techniques likely will be the most productive. This work redesigns the register file system of a modern throughput processor with a combined hardware and software solution that reduces register file energy without harming system performance. Throughput processors utilize a large number of threads to tolerate latency, requiring a large, energy-intensive register file to store thread context. Our results show that a compiler controlled register file hierarchy can reduce register file energy by up to 54%, compared to a hardware only caching approach that reduces register file energy by 34%. We explore register allocation algorithms that are specifically targeted to improve energy efficiency by sharing temporary register file resources across concurrently running threads and conduct a detailed limit study on the further potential to optimize operand delivery for throughput processors. Our efficiency gains represent a direct performance gain for power limited systems, such as GPUs.
616: Variations Among Experienced Surgeons and Cancer Control Rates after Radical Prostatectom (2007)

You have accessJournal of UrologyPodium 21, Sunday, May 20, 2007, 3:30 - 5:30 pm1 Apr 2007616: Variations Among Experienced Surgeons and Cancer Control Rates after Radical Prostatectom Fernando J. Bianco, Andrew J. Vickers, Angel M. Serio, James A. Eastham, Peter T. Scardino, Eric A. Klein, Alwyn M. Reuther, Michael W. Kaftan, and J. Edson Pontes Fernando J. BiancoFernando J. Bianco More articles by this author , Andrew J. VickersAndrew J. Vickers More articles by this author , Angel M. SerioAngel M. Serio More articles by this author , James A. EasthamJames A. Eastham More articles by this author , Peter T. ScardinoPeter T. Scardino More articles by this author , Eric A. KleinEric A. Klein More articles by this author , Alwyn M. ReutherAlwyn M. Reuther More articles by this author , Michael W. KaftanMichael W. Kaftan More articles by this author , and J. Edson PontesJ. Edson Pontes More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)30856-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "616: Variations Among Experienced Surgeons and Cancer Control Rates after Radical Prostatectom." The Journal of Urology, 177(4S), pp. 206–207 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 206-207 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Fernando J. Bianco More articles by this author Andrew J. Vickers More articles by this author Angel M. Serio More articles by this author James A. Eastham More articles by this author Peter T. Scardino More articles by this author Eric A. Klein More articles by this author Alwyn M. Reuther More articles by this author Michael W. Kaftan More articles by this author J. Edson Pontes More articles by this author Expand All Advertisement PDF DownloadLoading ...
Three-phase pole-by-pole model of a linear induction machine (1980)

This paper develops a stationary-reference-frame coupled circuit model for a 4-pole linear induction machine (l.i.m.), a model similar in nature to the abc-phase model used to predict conventional round-rotor machine behaviour. A comparison between model predictions and high-speed double-sided l.i.m. data shows that good predictions can be made using equivalent-circuit parameters calculated from machine dimensions. It is shown that the application of the (d, q) transformation slightly degrades the predictions for the machine studied, at the same time halving the computational time. The model derived requires a mathematical lengthening of the machine&apos;s primary. It is shown that results are improved when the actual length of the primary is used to calculate coupling coefficients for the model. Since the basic abc-phase 4-pole machine model is represented by a matrix differential equation of order 15, programming and solution time are relatively short as compared to some other methods.
KEY ROLE OF THE CHEMOKINE RECEPTOR CXCR3 IN MURINE CARDIAC ALLOGRAFT REJECTION. (2000)

Hancock, Wayne W.1,2; Lu, Bao3; Gao, Wei1; Csizmadia, Vilmos1; Faia, Kerrie L.1; King, Jennifer A.1; Smiley, Stephen T.1; Gerard, Craig J.3 Author Information
Geometrical Scaling Limits of Heat-Assisted Magnetic Recording (2020)

System-level requirements for heat-assisted magnetic recording at high areal density are presented in this article. The primary factors that affect bit error rate (BER) are spatial, or media, signal-to-noise ratio (SNR), reader SNR, and channel bit density (CBD). Spatial SNR is largely determined by the interaction between the writer properties and the media properties. For example, how well the thermal gradient matches the grain size. Spatial SNR also depends on how well the reader cross-track resolution matches the track pitch, and the quality of the written pattern. For any given level of spatial SNR, there exists a combination of CBD and reader SNR that results in the desired level of performance. This article elucidates some of the tradeoffs that may be needed to maintain BER as areal density increases, for different bit aspect ratio scenarios. For very high areal density, we show that the geometrical requirements are extremely aggressive, which will most likely require significant invention in head and drive architecture design.
Size Dependence of Two-Photon in Lead Salt Quantum Dots (2009)

Two-photon absorption (2PA) is measured for different sizes of lead-salt quantum dots, a slight increasing of the 2PA for smaller quantum-dots is observed and the results is discussed based on a four-band envelope function formalism.
Supplementary Tables from Preclinical Antitumor Activity of the Orally Available Heat Shock Protein 90 Inhibitor NVP-BEP800 (2023)

Supplementary Tables from Preclinical Antitumor Activity of the Orally Available Heat Shock Protein 90 Inhibitor NVP-BEP800
Decreased Androgen Receptor Levels and Receptor Function in Breast Cancer Contribute to the Failure of Response to Medroxyprogesterone Acetate (2005)

Previously, we reported that androgen receptor (AR), but not estrogen receptor (ER) or progesterone receptor (PR), is predictive of response to the synthetic progestin, medroxyprogesterone acetate (MPA), in a cohort of 83 patients with metastatic breast cancer. To further investigate the role of AR in determining response to MPA in this cohort, we analyzed AR levels by immunohistochemistry with two discrete antisera directed at either the NH2 or the COOH termini of the receptor. Compared with tumors that responded to MPA (n = 31), there was a significant decrease in the intensity and extent of AR immunoreactivity with both AR antisera in tumors from nonresponders (n = 52). Whereas only a single AR immunostaining pattern was detected in responders to MPA, reflecting concordance of immunoreactivity with the two AR antisera, tumors from nonresponders exhibited four distinct AR immunostaining patterns: (a) concordance with the two antibodies (31%), (b) staining only with the COOH-terminal antibody (33%), (c) staining only with the NH2-terminal antibody (22%), or (d) no immunoreactivity with either NH2- or COOH-terminal antibody (14%). DNA sequencing and functional analysis identified inactivating missense gene mutations in the ligand-binding domain of the AR in tumors from two of nine nonresponders positive with the NH2-terminal AR antisera but negative for COOH-terminal immunoreactivity and lacking specific, high-affinity dihydrotestosterone binding in tumor cytosol fractions. Tumors with more AR than the median level (37 fmol/mg protein) had significantly lower levels of PR (30 fmol/mg protein) than tumors with low AR (PR; 127 fmol/mg protein) despite comparable levels of ER. Ligand-dependent activation of the AR in human T47D and MCF-7 breast cancer cells resulted in inhibition of estradiol-stimulated cell proliferation and a reduction in the capacity of the ER to induce expression of the PR. These effects could be reversed using a specific AR antisense oligonucleotide. Increasing the ratio of AR to ER resulted in a greater androgen-dependent inhibition of ER function. Collectively, these data suggest that reduced levels of AR or impaired AR function contribute to the failure of MPA therapy potentially due to abrogation of the inhibitory effect of AR on ER signaling.
ChemInform Abstract: The Photochemistry of Pyrylium Salts: New Photohydrations and Photoamidations of Heterocycles Leading to Bicyclic Oxazolines and Functionalized Cyclopentenes. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Measurements of catecholamine‐mediated apoptosis of immunocompetent cells by capillary electrophoresis (1997)

Single cell analysis with capillary electrophoresis, a technique capable of detecting zeptomole quantities (10(-21) mole) of neurochemical species, has been used to demonstrate that lymphocytes are capable of active synthesis of dopamine and norepinephrine. Exposure of lymphocytes to catecholamines at concentrations as low as 10 nM leads to decreased proliferation and differentiation, e.g. interferon-gamma (IFN-gamma), interleukin-4 (IL-4) and immunoglobulin (Ig). In addition, both inhibition of dopamine uptake with nomifensine and inhibition of packing of catecholamines into vesicles with tetrabenazine, results in significantly lower levels of dopamine and norepinephrine (p < 0.01 and p < 0.05, respectively). The catecholamine-dependent inhibition of T- and B-lymphocyte activity is mediated via an induction of a Bcl-2/Bax and Fas/FasL involved apoptosis. These findings indicate a novel mechanism for regulation of lymphocyte activity in the central nervous system, whereby elevated regional levels of catecholamines might lead to the immunoprivilege of the brain.
Tetracyanoethylene addition to iron tricarbonyl complexes of substituted cyclooctatetraenes. Regioselectivity considerations during formation of the 2,3,4,10-tetrahapto adducts (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTetracyanoethylene addition to iron tricarbonyl complexes of substituted cyclooctatetraenes. Regioselectivity considerations during formation of the 2,3,4,10-tetrahapto adductsLeo A. Paquette, Steven V. Ley, Stefano Maiorana, David F. Schneider, Michael J. Broadhurst, and Roger A. BoggsCite this: J. Am. Chem. Soc. 1975, 97, 16, 4658–4667Publication Date (Print):August 1, 1975Publication History Published online1 May 2002Published inissue 1 August 1975https://pubs.acs.org/doi/10.1021/ja00849a031https://doi.org/10.1021/ja00849a031research-articleACS PublicationsRequest reuse permissionsArticle Views93Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fewer Worsening Heart Failure Events With HeartLogic on top of Standard Care: a Propensity-Matched Cohort Analysis (2023)

Integrating the HeartLogic algorithm in a well-equipped HF care path on top of standard care is associated with fewer worsening HF events and shorter duration of fluid retention-related hospitalizations.
[New concepts in therapy of type I allergic diseases]. (1993)

The molecular characterization of allergens with recombinant DNA techniques allowed cDNA sequences to be obtained and, hence, information regarding the primary structure of allergens. It is now possible to express well-defined recombinant allergens in heterologous expression systems and to obtain large amounts of highly pure recombinant allergens for the improvement of current diagnosis and therapy of type I allergic diseases. Due to extensive cross-reactivities and structural similarities of the relevant allergens it is possible to define a limited number of allergens, which is a prerequisite for allergen-specific therapeutic concepts. Specific concepts of active immunotherapy and strategies of passive therapeutic interference based on recombinant techniques are discussed.
Proximity to livestock farms and COVID-19 in the Netherlands, 2020–2021 (2022)

In this exploratory study with individual SARS-CoV-2 notification data and high-resolution spatial data associations were found between living near livestock farms and individuals' SARS-CoV-2 status in the Netherlands. Verification of the results in other countries is warranted, as well as investigations into possible underlying exposures and mechanisms.
Virtual Induction Machine Strategy for Converters in Power Systems with Low Rotational Inertia (2017)

This paper presents a novel comprehensive control strategy for grid-connected Voltage Source Converters (VSCs) in power systems with low rotational inertia.The proposed model is based on emulating the physical properties of an Induction Machine (IM) and taking advantage of its inherent grid-friendly properties, i.e. self-synchronization, virtual inertia, power and frequency oscillation damping.For that purpose, a detailed mathematical model of the IMs working principles is derived, which includes the possibility of obtaining the unknown grid frequency without a dedicated synchronization unit, but rather via processing the voltage and current magnitude measurements at the converter output.This eliminates the need for an inherently nonlinear phase-locked loop, characteristic for virtual synchronous machines, while simultaneously preserving the synchronization and damping properties of a conventional electrical machine.Several case studies are presented that validate the mathematical principles of the proposed model and conclusions on VSC performance are drawn.
A hybrid approach for large-scale optimizations of medium frequency propagation in coal mines (2011)

A method to analyze and optimize medium frequency (MF) wave propagation in coal mines is introduced. Specifically, a hybrid approach using ideal transmission line (TL) models in conjunction with strategically placed full-wave sections is demonstrated. This hybrid approach provides for a computationally efficient and accurate alternative to typical numerical methods. Specifically, this work demonstrates that conduction paths between transmitter and receiver can be accurately modeled with the hybrid approach, resulting in significantly improved computation speeds relative to full-wave simulations. With this hybrid approach, the complex propagation networks of coal mines can be analyzed, facilitating the optimization of conductor and/or antenna placement for improved performance of MF communication systems.