gebhart/patrepeval huggingface dataset:
23/#722 Procedural interventions for oligoprogression during treatment with immune checkpoint blockade in gynecologic malignancies (2022)

<h3>Objectives</h3> To evaluate feasibility and outcomes of procedural interventions for oligoprogressive disease among patients with gynecologic cancer treated with immune checkpoint blockade (ICB). <h3>Methods</h3> Patients with gynecologic cancers treated with ICB between 1/2013–10/2021 who underwent procedural interventions including surgical resection (OR), interventional radiology ablation (IR), or radiation therapy (RT) for oligoprogressive disease were identified. Procedures performed before ICB initiation, or ≥6 months (mos) after ICB completion were excluded. Long ICB duration prior to intervention was defined as ≥6 mos. PFS and OS were calculated from procedure date until disease progression or death, respectively. <h3>Results</h3> During the study period, 887 patients received ICB. Among patients with oligoprogressive disease, 41 underwent procedural intervention: 10 OR, 3 IR, and 28 RT. Primary tumor type included uterine (74%) and ovarian (23%). ICB regimen included PD-1/PD-L1 inhibitor (46%), PD-1/PD-L1 inhibitor + tyrosine kinase inhibitor (29%), PD-1/PD-L1 inhibitor + CTLA-4 inhibitor (12%), and PD-1/PD-L1 inhibitor + other (12%). Sites of oligoprogression included abdomen (32%), lung (17%), bone (17%), distant lymph node (17%), and vagina (10%). Subsequent treatment included continuation of same therapy (49%), other ICB (10%), or chemotherapy (29%). Short vs long ICB duration pre-procedure demonstrated median PFS of 9.2mos versus 5.6mos, and median OS of 36.1mos and 22.0mos, respectively. <h3>Conclusions</h3> Procedural interventions for patients with oligoprogression on ICB are feasible and demonstrate favorable outcomes. Early intervention appears to associate with prolonged PFS &amp; OS. With expanding use of ICB, it is important to investigate combined modalities to maximize therapeutic benefit for patients with gynecologic cancers.
The impact of gender and age in renal cell carcinoma: age is an independent prognostic factor in women but not men (2008)

5091 Background: Renal cell carcinoma (RCC) occurs twice as often in men as in women; however, the influence of gender on stage, grade, subtype and survival has not been studied in detail. If this imbalance in RCC incidence was related to gender-specific hormone levels, age could be a further significant variable. Methods: This study included 5,654 patients treated by nephrectomy at 10 international academic centers. Differences in gender, age, T, N, and M stage, Fuhrman grade, and histological subtype were evaluated with chi- square and Student’s t-tests. Kaplan-Meier survival estimates and Cox proportional hazards models addressed the impact of gender and age on disease-specific survival (DSS). Results: Of the 5,654 patients, 3,777 (67%) were men and 1,877 (33%) were women. Generally, women presented at lower T stages (p<0.001), less frequently had distant metastases (p<0.001) and had lower grade tumors (p<0.001). In addition, women more frequently had clear-cell (87% vs. 82%) and less frequently had papillary RCC (7% vs. 12%) than men (p<0.001). As a group, women had a 19% reduced risk of death from RCC than men (HR 0.81, 95% CI 0.73–0.90, p<0.001). Interestingly, the survival advantage for women was present to the greatest degree in the age group <40 years (p=0.0136), was intermediate in women aged 40–59 (p<0.001), and disappeared in patients aged 60 years and older (p=0.248). Among women, age was an independent predictor of DSS in multivariate analysis (HR 1.011, 95% CI 1.004–1.019, p=0.004). In contrast, age was not related to prognosis in men. Conclusions: Among women, age is an independent prognostic factor of DSS with the risk of RCC-specific death increasing by 1% with each year increase in age. As a group, women present with less advanced tumors, leading to a 19% reduced risk of RCC-specific death compared with men. This survival difference is present only in patients aged <60 years, but disappears in older patients. Since this gender based survival difference is not related to T, N, M stage, ECOG PS, or histological subtype, the role of estrogen on the development and progression of RCC needs to be studied. If a true estrogen effect on RCC does exists then the potential for hormone-targeted therapy in women will also need to be investigated. No significant financial relationships to disclose.
Prominent IgE-binding and cytokine-inducing capacities of a newly cloned N-terminal region of Der f 14, an apolipophorin-like house dust mite allergen (2017)

We previously characterized a 177-kDa allergen, M-177, from Dermatophagoides farinae. Thereafter, a counterpart to M-177 for Euroglyphus maynei was cloned as Eur m 14, and its sequence revealed that two environmental allergens, Mag 1 and Mag 3, are digested fragments of M-177. The aims of this study were to clone the cDNA of Der f 14 corresponding to M-177 and to elucidate the allergenic capacities of the N-terminal fragment of Der f 14 (Der f 14-N). Recombinant allergens were produced as trigger-factor-fused proteins in Escherichia coli. Der f 14-N showed the highest IgE-binding frequency among Der f 14-derived fragments in patients allergic to house dust mite by enzyme-linked immunosorbent assay. Der f 14-N showed the highest capacity to induce cell proliferation in murine lymphocyte and human peripheral mononuclear cells among Der f 14-derived fragments. Der f 14-N induced IL-13, IFN-γ and IL-17 production more than Der f 1 and Der f 2 in mouse, and induced IL-5 and IFN-γ production at levels comparable to those of Der f 1 and Der f 2 in some patients. The high prevalence of IgE binding to the Der f 14-N indicates that it could be an important mite allergen.
Biomass-Fueled Direct Carbon Fuel Cells (2018)

As one of the promising sustainable energy generation technologies, fuel cells have gained significant research interest and recent technological developments. There are various types of fuel cells, of which, the direct carbon fuel cells offer the opportunity for direct conversion of carbonaceous fuels to electricity. In this paper, the major aspects of biomass-fueled direct carbon fuel cells (DCFCs) are comprehensively reviewed. Current DCFC technologies are categorized based on the nature of electrolyte into one of four main types, i.e., molten carbonate, molten hydroxide, solid oxide, and hybrid type with various cell arrangements. The characterization technologies for biomass/biomass char fuels are summarized, including X-ray diffraction (XRD), thermogravimetric analysis (TGA), scanning electron microscope (SEM), and others. The information gained on fuel properties may be used to predict the electrochemical performance of DCFCs with the corresponding fuels. The performance of DCFCs fueled by various biomass chars is also summarized. Among all four types of DCFCs, SOFCs are the most widely employed. Finally, a brief summary of parameters that affect the cell performance is presented, such as the fuel property, temperature, external mechanical pressure, and stirring. The maximum power density, open circuit voltage (OCV), and current density vary within a large range depending on these parameters and the DCFC type. Although the biomass-fueled direct carbon fuel cell technology has some promise, it is still in the stages of research and development. The review concludes by identifying the main barriers to be addressed before widespread adoption of biomass-fueled DCFCs.
Characteristics of L-shaped built-in folded monopole antenna for handsets (2007)

This study introduces and analyzes the fundamental performance of an L-shaped built-in folded monopole antenna (LBFMA). Device performance is also compared with those of planar inverted-F antenna (PIFA) configuration. The results may be used as a first step in the antenna array design for multiple-antenna devices applied to MIMO applications.
Electron-beam-induced current observed for dislocations in diffused 4H-SiC P–N diodes (2004)

The electron-beam-induced current (EBIC) method was employed to investigate the electrical activity of dislocations in silicon carbide Schottky and diffused p–n diodes. Dislocations in Schottky diodes appear as dark spots with the EBIC current signal at the dislocations reduced with respect to the background. However, in p–n diodes, the same dislocations exhibited characteristic bright halos, with the EBIC current higher than that of the background. These bright halos were attributed to a nonuniform impurity distribution around dislocations caused by the high-temperature (∼2000 °C) diffusion process.
<title>Scaleable wireless web-enabled sensor networks</title> (2002)

Our goal was to develop a long life, low cost, scalable wireless sensing network, which collects and distributes data from a wide variety of sensors over the internet. Time division multiple access was employed with RF transmitter nodes (each w/unique16 bit address) to communicate digital data to a single receiver (range 1/3 mile). One thousand five channel nodes can communicate to one receiver (30 minute update). Current draw (sleep) is 20 microamps, allowing 5 year battery life w/one 3.6 volt Li-Ion AA size battery. The network nodes include sensor excitation (AC or DC), multiplexer, instrumentation amplifier, 16 bit A/D converter, microprocessor, and RF link. They are compatible with thermocouples, strain gauges, load/torque transducers, inductive/capacitive sensors. The receiver (418 MHz) includes a single board computer (SBC) with Ethernet capability, internet file transfer protocols (XML/HTML), and data storage. The receiver detects data from specific nodes, performs error checking, records the data. The web server interrogates the SBC (from Microsoft's Internet Explorer or Netscape's Navigator) to distribute data. This system can collect data from thousands of remote sensors on a smart structure, and be shared by an unlimited number of users.
Development of High-Strength Suspension Coil Springs with Improved Corrosion Fatigue Strength (2001)

For the weight reduction of suspension coil springs for automobiles, high-strength steel has been developed. Generally, strength and corrosion fatigue shows contradictory behavior, so the technological basis is to improve corrosion fatigue strength in addition to durability and sag resistance. As a solution for the problem, element design which improved the performance against corrosion and optimum condition of shot peening process were studied. Thus the high-strength suspension coil springs in this paper obtained superior corrosion fatigue strength, compared with the spring made of SUP7. Moreover, as a new basic evaluation method, corrosion fatigue test of springs with an artificial pit was proposed.
The advantage of mini electrode-equipped catheter for the radiofrequency ablation of paroxysmal supraventricular tachycardia (2022)

Introduction: Novel ablation catheters equipped with mini-electrodes (ME) offer high resolution mapping for target tissue. This study aimed to evaluate the mapping performance and efficacy of ME catheters in radiofrequency ablation of paroxysmal supraventricular tachycardias (PSVTs). Methods: We prospectively enrolled 136 patients who were undergoing catheter ablation of PSVT including 76 patients with atrioventricular nodal reentrant tachycardia (AVNRT) and 60 patients with atrioventricular reentrant tachycardia (AVRT) or Wolff-Parkinson-White (WPW) syndrome. Patients were randomized to the ME group (ablation using a 4.5mm tip ME catheter) or the control group (ablation using a conventional 4mm tip catheter). The number of ablation attempt and cumulative ablation time to ablation endpoints, which was defined as an emergence of junctional rhythm in AVNRT or accessory pathway (AP) block in AVRT/WPW syndrome were compared. Results: During ablation procedures, discrete SP or AP electrograms were found in 27 (39.7%) patients in the ME group and 13 (19.1%) patients in the control group. The primary study outcomes were significantly lower in the ME group (ablation attempt number: 2.0 [1–4] vs. 3.0 [2–7] in the ME and control group, p=0.032; ablation time: 23.5 [5.0–111.5] vs. 64.5 [16.0–185.0] seconds, p=0.013). According to the PSVT diagnosis, ablation time to junctional rhythm was significantly shorter in the ME group in AVNRT. In AVRT/WPW syndrome, both ablation attempt number and ablation time to AP block showed trends favoring the ME group. Conclusion: The novel ME catheter was advantageous for identifying pathway potentials and reducing initial ablation attempt number and time in PSVT ablation. (ClinicalTrials.gov number, NCT04215640)
Implementing a pharmacogenetic-driven algorithm to guide dual antiplatelet therapy (DAPT) in Caribbean Hispanics: protocol for a non-randomised clinical trial (2020)

NCT03419325; Pre-results.
ChemInform Abstract: A Highly Stereoselective Michael Addition to an α,β‐ Unsaturated Ester as the Crucial Step in the Synthesis of a Novel . beta.‐Amino Acid‐Containing Fibrinogen Receptor Antagonist. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
HAWA'AK: An end-to-end air quality monitoring system for Qatar (2012)

The effect of air pollution on human health is considered a major and serious problem, globally. The purpose of air quality monitoring is not merely to collect data but to provide the information required by scientists, policy-makers and planners to enable them to make informed decisions on managing and improving the environment, as well as to present useful information for public end-users. Monitoring fulfills a central role in this process, providing the necessary, sound scientific basis for developing policies and strategies, setting objectives, assessing compliance with targets and planning enforcement action. Traditionally, bulky air quality monitoring stations are used for collecting various gas concentrations. These stations include many reference analyzers. Although they have a high level of accuracy, such stations require frequent calibration and maintenance and they need access to power sockets mainly for air conditioning, which limits their use on a large scale. Research and industrial bodies are focusing on developing a new generation of sensing stations at a low cost, smaller size, and with more mobility features. Variations of such stations are being used in different indoor and outdoor environments for both residential and industrial applications. These sensor stations are generally deployed as a wireless sensor network (WSN). A WSN is composed of a number of sensing stations transmitting wirelessly the information they capture. A sensing station is generally composed of a power unit, processing unit, sensing unit, and communication unit. In this work, a real-time air quality monitoring system is presented. This system is based on utilizing multi-gas (MG) monitoring stations that communicate with a platform by means of machine-to-machine communication. Each MG monitoring station includes gaseous sensing elements, a data logging component, and a wireless communication board. They are powered by solar energy. The platform is located on a backend server where data cleaning and filtering operations are carried out. In addition, this platform converts the received data to useful information that is delivered to users through web portal and mobile applications. The system uses a high density of sensing stations per unit area in order to provide localized pollution information, as opposed to bulky analyzers deployed in limited numbers.
A Discrete-Time Digital-IF Interference-Robust Ultrawideband Pulse Radio Transceiver Architecture (2009)

This paper discusses the challenges in ultrawideband pulse radio transceiver design and proposes an architecture operating between 3.1 and 10.6 GHz to address them. The 7.5-GHz band is subdivided into multiple channels of 500 MHz each to relax the requirements for pulse generation, transceiver synchronization, and group-delay flatness. The pulse bases for these channels are stored in digital memories and are used for pulse generation on the transmit side and correlation on the receive side. The transceiver can operate in combination with a fast interferer detector that quickly sweeps through the channels to determine which channels are occupied by large interferers and are thus unsuitable for communication. The all-digital pulse bases allow the transceiver to quickly switch between different channels to avoid interferers without needing multiple or, alternatively, broadband fast-settling phase-locked loops. The frequency plan allows the most critical 802.11 interferers to be pushed to higher frequencies during the first block downconversion where they are attenuated by the low-pass filters of the receiver. The wideband intermediate-frequency correlation architecture significantly relaxes the speed requirement of the digital circuit and the local memories. Several signal-processing techniques to eliminate sampling images in the transmitter as well as spurious image responses in the receiver are also presented. The proposed architecture is digitally intensive and, hence, can take advantage of technology scaling.
SEM Observations on the Mechanism of Platelet Release from Megakaryocytes (1979)

Normal human bone marrow megakaryocytes were examined with the scanning electron microscope (SEM) to clarify the mechanism of platelet release. Several types of megakaryocytes were dtected according to their surface appearance, i.e. with wrinkles, ridges, villous formations, round blebs and cells with platelets still attached to the cell membrane. These observations are consistent with the concept that bleb formation is at least one of the mechanisms for platelet liberation.
Perm Web: remote parallel and distributed volume visualization (1997)

In this paper we present a system for visualizing volume data from remote supercomputers (PermWeb). We have developed both parallel volume rendering algorithms, and the World Wide Web software for accessing the data at the remote sites. The implementation uses Hypertext Markup Language (HTML), Java, and Common Gateway Interface (CGI) scripts to connect World Wide Web (WWW) servers/clients to our volume renderers. The front ends are interactive Java classes for specification of view, shading, and classification inputs. We present performance results, and implementation details for connections to our computing resources at the University of California Santa Cruz including a MasPar MP-2, SGI Reality Engine-RE2, and SGI Challenge machines. We apply the system to the task of visualizing trabecular bone from finite element simulations. Fast volume rendering on remote compute servers through a web interface allows us to increase the accessibility of the results to more users. User interface issues, overviews of parallel algorithm developments, and overall system interfaces and protocols are presented. Access is available through Uniform Resource Locator (URL) http://www.cse.ucsc.edu/research/slvg/. 26 refs., 7 figs.
Discovery of Novel Central Nervous System Penetrant Metabotropic Glutamate Receptor Subtype 2 (mGlu2) Negative Allosteric Modulators (NAMs) Based on Functionalized Pyrazolo[1,5-a]pyrimidine-5-carboxamide and Thieno[3,2-b]pyridine-5-carboxamide Cores (2018)

A scaffold hopping exercise from a monocyclic mGlu<sub>2</sub> NAM with poor rodent PK led to two novel heterobicyclic series of mGlu<sub>2</sub> NAMs based on either a functionalized pyrazolo[1,5- a]pyrimidine-5-carboxamide core or a thieno[3,2- b]pyridine-5-carboxamide core. These novel analogues possess enhanced rodent PK, while also maintaining good mGlu<sub>2</sub> NAM potency, selectivity (versus mGlu<sub>3</sub> and the remaining six mGlu receptors), and high CNS penetration. Interestingly, SAR was divergent between the new 5,6-heterobicyclic systems.
Predicting Visual Sensitivity in Retinal Prosthesis Patients (2009)

This is the first study to demonstrate that, on the single-electrode level, retinal electrical stimulation in humans can produce visual qualia that are predictable using a quantitative model, a prerequisite for a successful retinal prosthesis. (ClinicalTrials.gov number, NCT00279500.).
Sub-surface electrical conductivity imaging via contactless measurements (2003)

A new medical imaging modality is introduced to image electrical conductivity of living tissues via contactless measurements. A sensitivity matrix which relates the perturbation in magnetic field measurements to the conductivity perturbations is obtained for a coplanar 7/spl times/7-coil array placed nearby the upper surface of a 10/spl times/10/spl times/5 (cm) conductive body. Images are using truncated pseudo-inverse. It is observed that voxel perturbations at a 2 cm depth can be identified. However, resolution gradually decreases for deeper conductivity perturbations.
Photodegradation of Fluorescein in Solutions Containingn-Propyl Gallate (2004)

The frequency domain technique was applied to measure the effect of n-propyl gallate (nPG) on the apparent photodegradation rate of fluorescein in aqueous solutions. The illuminating light was modulated and the change in fluorescence from the illuminated region was detected synchronously. A constant flow rate was imposed on the fluorescein solution to control the mass transport of fluorescein into the illuminated region. The photodegradation response was described by a model which assumed two steps: (1) singlet oxygen production via energy transfer between the excited triplet state of fluorescein and molecular oxygen in the ground triplet state and (2) photodegradation via the interaction of fluorescein with singlet oxygen. It was assumed that nPG affects the photodegradation of fluorescein by quenching the oxygen singlet state. In the context of this model, the rate of singlet oxygen quenching by nPG was found to be (1.3 ± 0.2) × 109 s-1M-1. The product of the singlet oxygen photosensitization rate, kox, and the photodegradation rate, kpd, was koxkpd = (0.60 ± 0.3) × 1017 s-2 M-2. Photodegradation was observed in argon purged solutions and high concentrations of nPG, suggesting another photodegradation mechanism, such as direct electron transfer between fluorescein in the excited triplet state and fluorescein in the ground state. nPG also quenches the excited singlet state of fluorescein with a rate of (2.5 ± 0.3) × 109 s-1 M-1.