gebhart/patrepeval huggingface dataset:
An Application of Neural Network in Corridor Travel Time Prediction in the Presence of Traffic Incidents (2006)

Incident related traffic congestion leads to enormous economic loss each year in the world. To predict the traffic situation when an incident occurs and disseminate the information to the traveling public can alleviate the traffic congestion caused by the incident. This research collected traffic incident data and traffic condition data from a highway corridor (Interstate Highway 66 Eastbound) in Northern Virginia. After pre-processing, data fusion between the two different data sources was successfully conducted and the cross reference between the incident and traffic condition data sets was set up. Based on the fused data sets, a neural network model for corridor travel time prediction in the presence of traffic incidents was developed. After the model was trained and optimized, randomly selected new data was used to test the performances of the proposed model under three different scenarios: (1) the input variables were incident related information only; (2) the input variables were current traffic condition information only; (3) the input variables included both the incident related information and the current traffic condition information. The performance indicators of the model were calculated under the three scenarios, and the statistics were compared. The results demonstrate that it is possible to accurately predict the future travel time within a corridor in the presence of traffic incidents when given sufficient amount of data. With exceptional learning ability, neural network is proven to be an effective tool in modeling this travel time prediction problem. The developed neural network delivers a good fit in most cases, indicating that it is a successful model. It is also observed that incident related information roughly dictates the trend of the impact on traffic, while current traffic condition provides a dynamic environment where the incident occurs. Addition of current traffic condition information can further improve the prediction accuracy. The predicted travel time information is valuable for traveler information systems and traffic incident management systems.
Synthesis of Novel Pyrazolines via 1,3‐Dipolar Cycloadditions of Heterocyclic Isopropenes. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Supplementary Figure 1, Tables 1-4 from Topology of NGEP, a Prostate-Specific Cell:Cell Junction Protein Widely Expressed in Many Cancers of Different Grade Level (2023)

Supplementary Figure 1, Tables 1-4 from Topology of NGEP, a Prostate-Specific Cell:Cell Junction Protein Widely Expressed in Many Cancers of Different Grade Level
Heat shock potentiates aminoglycosides against gram-negative bacteria by enhancing antibiotic uptake, protein aggregation, and ROS (2023)

The potentiation of antibiotics is a promising strategy for combatting antibiotic-resistant/tolerant bacteria. Herein, we report that a 5-min sublethal heat shock enhances the bactericidal actions of aminoglycoside antibiotics by six orders of magnitude against both exponential- and stationary-phase <i>Escherichia coli</i>. This combined treatment also effectively kills various <i>E. coli</i> persisters, <i>E. coli</i> clinical isolates, and numerous gram-negative but not gram-positive bacteria and enables aminoglycosides at 5% of minimum inhibitory concentrations to eradicate multidrug-resistant pathogens <i>Acinetobacter baumannii</i> and <i>Klebsiella pneumoniae</i>. Mechanistically, the potentiation is achieved comprehensively by heat shock-enhanced proton motive force that thus promotes the bacterial uptake of aminoglycosides, as well as by increasing irreversible protein aggregation and reactive oxygen species that further augment the downstream lethality of aminoglycosides. Consistently, protonophores, chemical chaperones, antioxidants, and anaerobic culturing abolish heat shock-enhanced aminoglycoside lethality. We also demonstrate as a proof of concept that infrared irradiation- or photothermal nanosphere-induced thermal treatments potentiate aminoglycoside killing of <i>Pseudomonas aeruginosa</i> in a mouse acute skin wound model. Our study advances the understanding of the mechanism of actions of aminoglycosides and demonstrates a high potential for thermal ablation in curing bacterial infections when combined with aminoglycosides.
Compact high-power low-jitter semiconductor mode-locked laser module for photonic A/D converter applications (2003)

Low-capacitance, two-section, curved-waveguide gain elements were packaged with lensed polarization-maintaining fiber within standard-sized butterfly-style packages and shown to produce low-jitter pulses when used within a harmonically modelocked sigma cavity laser (jitter = 25 fs; 10 Hz - 10 MHz). Incorporation of a high finesse etalon filter into the sigma-cavity loop resulted in greater than 25 dB suppression of the supermode spurs while maintaining low integrated phase noise (jitter = 30 fs; 10 Hz - 10 MHz). A module containing the in-line sigma-cavity modelocked laser source and packaged semiconductor optical amplifiers was developed to create a configurable low jitter pulse source.
A Comparison Of Physical Autocorrelation And Digital Wiener Spectrum Techniques For Screen-Film Evaluation (1986)

The measurement of the Wiener spectrum associated with screen-film noise has beep widely reported in recent years, and digital data obtained by microdensitometer slit-scanning is now almost a standard art. However, physical autocorrelation techniques, described and developed for other types of imagery, might have powerful advantages in some respects. An analysis is carried out of the fundamental statistics associated with the two approaches, and some attractive features associated with physical autocorrelation are illustrated.
Second-Order Inference for the Mean of a Variable Missing at Random (2016)

We present a second-order estimator of the mean of a variable subject to missingness, under the missing at random assumption. The estimator improves upon existing methods by using an approximate second-order expansion of the parameter functional, in addition to the first-order expansion employed by standard doubly robust methods. This results in weaker assumptions about the convergence rates necessary to establish consistency, local efficiency, and asymptotic linearity. The general estimation strategy is developed under the targeted minimum loss-based estimation (TMLE) framework. We present a simulation comparing the sensitivity of the first and second-order estimators to the convergence rate of the initial estimators of the outcome regression and missingness score. In our simulation, the second-order TMLE always had a coverage probability equal or closer to the nominal value 0.95, compared to its first-order counterpart. In the best-case scenario, the proposed second-order TMLE had a coverage probability of 0.86 when the first-order TMLE had a coverage probability of zero. We also present a novel first-order estimator inspired by a second-order expansion of the parameter functional. This estimator only requires one-dimensional smoothing, whereas implementation of the second-order TMLE generally requires kernel smoothing on the covariate space. The first-order estimator proposed is expected to have improved finite sample performance compared to existing first-order estimators. In the best-case scenario of our simulation study, the novel first-order TMLE improved the coverage probability from 0 to 0.90. We provide an illustration of our methods using a publicly available dataset to determine the effect of an anticoagulant on health outcomes of patients undergoing percutaneous coronary intervention. We provide R code implementing the proposed estimator.
Laboratory Evaluation of Water Swellable Materials for Fracture Shutoff (2008)

Abstract The existence of high permeability features such as fissures, fractures, and eroded out permeability zones, diminishes the sweep efficiency of any water, gas, or polymer flooding. This paper presents the laboratory evaluation of three water swellable materials that can be bullheaded into the well to shut off fractures. The water swellable materials would be mixed on the fly, entering fissures and fracture systems as they swell without invading the matrix of the rock. The rate of absorption can be controlled based on the particle size, carrier fluid, and formation fluid. This conformance technology is also applicable to address loss circulation problems in production and injection wells. The following materials were evaluated: (a) a polyacrylamide polymer, (b) a chloroprene rubber, and (c) a nitrile rubber. The polyacrylamide polymer is capable of absorbing 30 to 400 times its own weight in water while the two rubbers swell approximately 5 to 10 times their original weight. The water swellable materials were evaluated for effectiveness to: (1) provide controllable swelling rates at different conditions, (2) shut off the flow of water in synthetic cores with simulated fractures at 135°F, and (3) provide long-term thermal stability in H2S and CO2 environments. Discussed are: (1) the methodology used for measurement of swelling properties for each material at different conditions including carrier fluid, particle size, and temperature, and (2) core flow tests with simulated fractures. These materials are nontoxic and do not contain heavy metal crosslinkers. Based on this study, these materials present an innovative technology for fracture shutoff and to control loss circulation problems. In addition, these materials are resistant to acid contamination in CO2 and H2S environments.
Data from Multifunctional mRNA-Based CAR T Cells Display Promising Antitumor Activity Against Glioblastoma (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Most chimeric antigen receptor (CAR) T-cell strategies against glioblastoma have demonstrated only modest therapeutic activity and are based on persistent gene modification strategies that have limited transgene capacity, long manufacturing processes, and the risk for uncontrollable off-tumor toxicities. mRNA-based T-cell modifications are an emerging safe, rapid, and cost-effective alternative to overcome these challenges, but are underexplored against glioblastoma.&lt;/p&gt;Experimental Design:&lt;p&gt;We generated mouse and human mRNA-based multifunctional T cells coexpressing a multitargeting CAR based on the natural killer group 2D (NKG2D) receptor and the proinflammatory cytokines IL12 and IFNα2 and assessed their antiglioma activity &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;.&lt;/p&gt;Results:&lt;p&gt;Compared with T cells that either expressed the CAR or cytokines alone, multifunctional CAR T cells demonstrated increased antiglioma activity &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; in three orthotopic immunocompetent mouse glioma models without signs of toxicity. Mechanistically, the coexpression of IL12 and IFNα2 in addition to the CAR promoted a proinflammatory tumor microenvironment and reduced T-cell exhaustion as demonstrated by &lt;i&gt;ex vivo&lt;/i&gt; immune phenotyping, cytokine profiling, and RNA sequencing. The translational potential was demonstrated by image-based single-cell analyses of mRNA-modified T cells in patient glioblastoma samples with a complex cellular microenvironment. This revealed strong antiglioma activity of human mRNA-based multifunctional NKG2D CAR T cells coexpressing IL12 and IFNα2 whereas T cells that expressed either the CAR or cytokines alone did not demonstrate comparable antiglioma activity.&lt;/p&gt;Conclusions:&lt;p&gt;These data provide a robust rationale for future clinical studies with mRNA-based multifunctional CAR T cells to treat malignant brain tumors.&lt;/p&gt;&lt;/div&gt;
Effect of single amino acid substitutions on the thermal stability of the .alpha. subunit of tryptophan synthase (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of single amino acid substitutions on the thermal stability of the .alpha. subunit of tryptophan synthaseC. R. Matthews, M. M. Crisanti, G. L. Gepner, G. Velicelebi, and J. M. SturtevantCite this: Biochemistry 1980, 19, 7, 1290–1293Publication Date (Print):April 1, 1980Publication History Published online1 May 2002Published inissue 1 April 1980https://pubs.acs.org/doi/10.1021/bi00548a004https://doi.org/10.1021/bi00548a004research-articleACS PublicationsRequest reuse permissionsArticle Views102Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Identification of the Putative Bryostatin Polyketide Synthase Gene Cluster from “Candidatus Endobugula sertula”, the Uncultivated Microbial Symbiont of the Marine Bryozoan Bugula neritina (2006)

The bryostatins are protein kinase C modulators with unique structural features and potential anticancer and neurological activities. These complex polyketides were isolated from the marine bryozoan Bugula neritina, but recent studies indicate that they are produced by the uncultured symbiotic bacterium "Candidatus Endobugula sertula" ("E. sertula"). Here we present the putative biosynthetic genes: five modular polyketide synthase (PKS) genes, a discrete acyltransferase, a beta-ketosynthase, a hydroxy-methyl-glutaryl CoA synthase (HMG-CS), and a methyltransferase. The cluster was sequenced in two closely related "E. sertula" strains from different host species. In one strain the gene cluster is contiguous, while in the other strain it is split into two loci, with one locus containing the PKS genes and the other containing the accessory genes. Here, we propose a hypothesis for the biosynthesis of the bryostatins. Thirteen PKS modules form the core macrolactone ring, and the pendent methyl ester groups are added by the HMG-CS gene cassette. The resulting hypothetical compound bryostatin 0 is the common basis for the 20 known bryostatins. As "E. sertula" is to date uncultured, heterologous expression of this biosynthetic gene cluster has the potential of producing the bioactive bryostatins in large enough quantities for development into a pharmaceutical.
On the decidability of accessibility problems (extended abstract) (2000)

Article Free Access Share on On the decidability of accessibility problems (extended abstract) Authors: Rajeev Motwani Department of Computer Science, Stanford University Department of Computer Science, Stanford UniversityView Profile , Rina Panigrahy Cisco Systems, San Jose, CA Cisco Systems, San Jose, CAView Profile , Vijay Saraswat AT&T Shannon Laboratory, 180 Park Ave, Florham Park, NJ AT&T Shannon Laboratory, 180 Park Ave, Florham Park, NJView Profile , Suresh Ventkatasubramanian AT&T Shannon Laboratory, 180 Park Ave, Florham Park, NJ AT&T Shannon Laboratory, 180 Park Ave, Florham Park, NJView Profile Authors Info & Claims STOC '00: Proceedings of the thirty-second annual ACM symposium on Theory of computingMay 2000 Pages 306–315https://doi.org/10.1145/335305.335341Published:01 May 2000Publication History 17citation389DownloadsMetricsTotal Citations17Total Downloads389Last 12 Months7Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
ChemInform Abstract: Synthesis and Antiviral Studies of Unsaturated Analogues of Isomeric Dideoxynucleosides. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Energy Efficient Cooperative Multicast Scheme Based on Selective Relay (2012)

Multicast communication has been researched for many years in efforts to simultaneously achieve high throughput and good fairness, which have a trade-off relationship. Recently, a cooperative multicast scheduling scheme was proposed. It is considered a promising solution owing to its trade-off characteristics realized by promoting user cooperation among group members. However, it requires significant relay power consumption for user cooperation, since all group members in a good channel condition should relay without checking whether there is at least one user requesting a relay in the transmission boundary. Therefore, in order to resolve this inefficiency, we proposed an energy efficient cooperative multicast scheme (EECM) based on selective relay. We can achieve reduced unnecessary relay power expenditure by selecting relay users with consideration of the condition of nearby users. The performance results derived from a numerical analysis reveal that the proposed scheme requires less energy consumption than the existing solution with almost the same throughput performance.
Work-stealing without the baggage (2012)

Work-stealing is a promising approach for effectively exploiting software parallelism on parallel hardware. A programmer who uses work-stealing explicitly identifies potential parallelism and the runtime then schedules work, keeping otherwise idle hardware busy while relieving overloaded hardware of its burden. Prior work has demonstrated that work-stealing is very effective in practice. However, work-stealing comes with a substantial overhead: as much as 2x to 12x slowdown over orthodox sequential code.
Characterizing the effect of demographics, cardiorespiratory factors, and inter-subject variation on maternal heart rate variability in pregnancy with statistical modeling: a retrospective observational analysis (2022)

Pregnancy complications are associated with insufficient adaptation of the maternal autonomic nervous system to the physiological demands of pregnancy. Consequently, assessing maternal heart rate variability (mHRV)-which reflects autonomic regulation-is a promising tool for detecting early deterioration in maternal health. However, before mHRV can be used to screen for complications, an understanding of the factors influencing mHRV during healthy pregnancy is needed. In this retrospective observational study, we develop regression models to unravel the effects of maternal demographics (age, body mass index (BMI), gestational age (GA), and parity), cardiorespiratory factors (heart rate and breathing rate), and inter-subject variation on mHRV. We develop these models using two datasets which are comprised of, respectively, single measurements in 290 healthy pregnant women and repeated measurements (median = 8) in 29 women with healthy pregnancies. Our most consequential finding is that between one-third and two-thirds of the variation in mHRV can be attributed to inter-subject variability. Additionally, median heart rate dominantly affects mHRV (p < 0.001), while BMI and parity have no effect. Moreover, we found that median breathing rate, age, and GA all impact mHRV (p < 0.05). These results suggest that personalized, long-term monitoring would be necessary for using mHRV for obstetric screening.
Voltage/current measurement performance and power supply rejection in all-digital Class-D power amplifiers (2016)

Low-noise and low-distortion voltage and current acquisition circuits, both analog and digital, are required for the control systems of precision, high-power switch-mode (Class-D) amplifiers used in nanometer-accuracy mechatronic systems. In this paper, the achievable linearity and noise of analog signal processing elements, such as sensors or active filters, is investigated and their performance in a closed-loop control system is demonstrated. Resistive voltage dividers are sufficiently linear but are subject to resistor noise. Nonetheless, a signal-to-noise ratio (SNR) of 130dB is achievable. Shunt resistors can achieve a total harmonic distortion (THD), limited by self-heating, of <;-120dB, whereas galvanically isolated, industrial current sensors achieve an insufficient THD of ≈-90dB. High-order active op-amp filters, which are used, e.g., to amplify and condition a shunt resistor voltage, can achieve a THD of -120dB. Furthermore, as a subsequent signal digitization is required for the control system, it is shown how the SNR of analog-to-digital converters can be improved sufficiently for the discussed application by oversampling, and how this process affects the feedback system's phase margin. In order to reveal the performance of a closed-loop system employing the key parts of the signal acquisition components, the results of the sensor analysis are implemented in a comprehensive computer simulation model of a digitally controlled switch-mode power amplifier. The analyzed 400V, 500VA converter system achieves a THD <;-117dB and an SNR (DC-10kHz) >110dB while operating at switching frequencies up to 500kHz.
Balanced tournament designs with almost orthogonal resolutions (1990)

Abstract A balanced tournament design, BTD(n) , defined on a 2 n —set V is an arrangement of the ( ) distinct unordered pairs of the elements of V into an n × 2 n − 1 array such that (1) every element of V is contained in precisely one cell of each column, and (2) every element of V is contained in at most two cells of each row. In this paper, we investigate the existence of balanced tournament designs with a pair of almost orthogonal resolutions. These designs can be used to construct doubly resolvable (ν, 3, 2)- BIBD s and, in our smallest applications, have been used to construct previously unknown doubly resolvable (ν, 3, 2)- B I B D s.
Synthesis of functionalized alternating olefin copolymer and modification to graft copolymer by hydrosilylation (2000)

Functionalized copolymers were synthesized by the copolymerization of ethylene and 1,9-decadiene with Me2Si(Flu)2ZrMe2–MAO catalyst system. Alternating copolymers were obtained with the degree of alternation higher than 98.2%. Undesirable side reactions such as cyclization and crosslinking were found completely suppressed. The resulting copolymer was quantitatively grafted by polysiloxanes by the hydrosilylation reaction as shown in the scheme. This is the first result reporting the alternating copolymerization of dienes and ethylene without any side reactions of a second double bond and the quantitative functionalization on the side chains of the copolymers.