gebhart/patrepeval huggingface dataset:
Use of Computerized Neurocognitive Assessment Software for the Detection of Alcohol Intoxication (2020)

Background: Acute ingestion of alcohol impairs cognitive function and poses significant threat to public health and safety with impaired operation of motor vehicles. However, there is a lack of access to tools to assess one's cognitive impairment due to alcohol. The purpose of this study was to explore the use of a neuropsychological assessment software, BrainCheck, to assess levels of alcohol impairment based on performance on the neuropsychological assessments. Methods: We administered the BrainCheck battery to 91 volunteer participants. Participants were required to take a baseline battery prior to any alcohol ingestion, and another testing battery after a voluntary drinking period. Blood alcohol concentration (BAC) for the participant was obtained using a breathalyzer. We performed statistical analysis comparing alcohol vs. non-alcohol performance on the BrainCheck battery, and used significant metrics of these assessments to generate predictive models. Results: Statistical analyses were performed comparing participants performance on the BrainCheck battery before and after alcohol consumption. Comparison was also done comparing performance between an intoxicated group with a BAC &gt; 0.05, and a sober group with a BAC ≤ 0.05. Two assessment metrics were found to be significant among comparison groups after P-value correction, and four test metrics were observed to moderately correlate (|r| &gt; 0.40) with BAC levels. Three linear regression models (least-squares, ridge and LASSO) were built to predict participant BAC levels, with the best performing model being the least-squares model with a RMSE of 0.027. We also built a predictive logistic regression model to detect whether the participant is intoxicated or not, with 80.6% accuracy, 73.3% sensitivity, and 75.0% specificity. Discussion: The BrainCheck battery has potential to predict alcohol impairment, including participant BAC levels and if the participant is intoxicated or not. BrainCheck provides another option to assess an individual's cognitive impairment due to alcohol, with the utility of being portable and available on one's smartphone.
Author Correction: Probing the physical limits of reliable DNA data retrieval (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Cytokine Profiles and Severity of Influenza Infection in Transplant Recipients (2018)

Influenza is responsible for significant morbidity after transplantation. We evaluated T-helper 1/T-helper 2 (Th2) cytokines and interleukin (IL) 10 levels during influenza infection in the posttransplant setting. Serum samples from 277 transplant recipients were analyzed at influenza diagnosis and 28 days later for interferon gamma (IFN-γ), IL-4, IL-13, and IL-10. IL-13 levels were associated with protection against pneumonia and intensive care unit (ICU) admission, whereas the IFN-γ/IL-13 ratio and IL-10 levels were associated with an increased risk of pneumonia and ICU admission. This association was independent of viral load. A skewing of immune responses toward Th2 in transplant patients appears to confer protection from severe influenza infection, independent of viral load.
Correlation with Invasive Left Ventricular Filling Pressures and Prognostic Relevance of the Echocardiographic Diastolic Parameters Used in the 2016 Esc Heart Failure Guidelines and in the 2016 Ase/Eacvi Recommendations: A Systematic Review in Patients with Heart Failure with Preserved Ejection Fraction (2018)

Only a small number of studies validated the use of echocardiographic parameters at rest in patients with HFpEF. The best established parameter appears to be E/e', but the existing data only show modest correlations of E/e' with invasive filling pressures and outcomes in HFpEF.
Rapid Photocrosslinkable Thermoresponsive Injectable Polyphosphazene Hydrogels (2010)

Rapidly photocrosslinkable and thermosensitive polyphosphazene polymers have been prepared to overcome the limitations associated with long UV exposure. Short UV exposure on the thermosensitive gels under mild conditions leads to quick photocrosslinking of the acrylate groups in the polymer network, and results in a dual crosslinked network with enhanced mechanical strength. The accelerated photocrosslinking can be attributed to the high reactivity of the acrylate double bond and hydrophobic interactions in the polymer network. The effects on the degree of photocrosslinking of the UV light intensity and the concentration of the photoinitiator were studied. In vitro and in vivo photocrosslinkings were accomplished within 120 and 180 s of exposure times, respectively. The degradation rate of the polymers depended on the degree of acrylate substitution in the polymer network. These results demonstrate that the injectable hydrogels with desired mechanical properties and degradation rates can be created in situ under mild photocrosslinkable conditions, and the dual crosslinkable acrylated poly(organophosphazenes) may hold great promise for biomedical delivery applications of biological molecules, cells, and drugs.
Selective laser trabeculoplasty: Does energy dosage predict response? (2013)

Within the range of total energy examined, there is a positive correlation between total energy used and amount of pressure reduction achieved at up to 3 years of follow-up. This may be useful in determining the optimal energy dosage for maximum effect for patients receiving SLT.
Measurement of the azimuthal ordering of charged hadrons with the ATLAS detector (2012)

This paper presents a study of the possible ordering of charged hadrons in the azimuthal angle relative to the beam axis in high-energy proton-proton collisions at the Large Hadron Collider (LHC). A spectral analysis of correlations between longitudinal and transverse components of the momentum of the charged hadrons, driven by the search for phenomena related to the structure of the QCD field, is performed. Data were recorded with the ATLAS detector at center-of-mass energies of ffiffi ffi s p 900 GeV and ffiffi ffi s p 7 TeV.
Discovery of 9-(6-Aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a Potent, Selective, and Orally Available Mammalian Target of Rapamycin (mTOR) Inhibitor for Treatment of Cancer (2011)

The mTOR mediated PI3K/AKT/mTOR signal transduction pathway has been demonstrated to play a key role in a broad spectrum of cancers. Starting from the mTOR selective inhibitor 1 (Torin1), a focused medicinal chemistry effort led to the discovery of an improved mTOR inhibitor 3 (Torin2), which possesses an EC(50) of 0.25 nM for inhibiting cellular mTOR activity. Compound 3 exhibited 800-fold selectivity over PI3K (EC(50): 200 nM) and over 100-fold binding selectivity relative to 440 other protein kinases. Compound 3 has significantly improved bioavailability (54%), metabolic stability, and plasma exposure relative to compound 1.
Purification and characterization of multiple forms of the pineapple-stem-derived cysteine proteinases ananain and comosain (1994)

A mixture of ananain (EC 3.4.22.31) and comosain purified from crude pineapple stem extract was found to contain numerous closely related enzyme forms. Chromatographic separation of the major enzyme forms was achieved after treatment of the mixture with thiol-modifying reagents: reversible modification with 2-hydroxyethyl disulphide provided enzyme for kinetic studies, and irreversible alkylation with bromotrifluoroacetone or iodoacetamide gave enzyme for structural analyses by 19F-n.m.r. and electrospray mass spectrometry respectively. Structural and kinetic analyses revealed comosain to be closely related to stem bromelain (EC 3.4.22.32), whereas ananain differed markedly from both comosain and stem bromelain. Nevertheless, differences were seen between comosain and stem bromelain in amino acid composition and kinetic specificity towards the epoxide inhibitor E-64. Differences between five isolatable alternative forms of ananain were characterized by amidolytic activity, thiol stoichiometry and accurate mass determinations. Three of the enzyme forms displayed ananain-like amidolytic activity, whereas the other two forms were inactive. Thiol-stoichiometry determinations revealed that the active enzyme forms contained one free thiol, whereas the inactive forms lacked the reactive thiol required for enzyme activity. M.s. provided direct evidence for oxidation of the active-site thiol to the corresponding sulphinic acid.
[A case of lung metastasis from esophageal cancer resistant to fluorouracil and cisplatin combination therapy but responsive to radiation therapy]. (2012)

At present, fluorouracil and cisplatin combination therapy is the standard chemotherapy against esophageal cancer, but the choice of second-line chemotherapy is controversial. Furthermore, the effect of radiation therapy against lung metastasis from esophageal cancer is unclear. We report a case of lung metastasis from esophageal cancer resistant to fluorouracil and cisplatin combination therapy but responsive to radiation therapy. The patient was a 55-year-old woman who had undergone an operation for esophageal cancer at another hospital. A single right lung metastasis appeared 1 year after the operation. Combined fluorouracil and cisplatin therapy was administrated for 5 courses, but the lung metastasis increased in size. Afterwards, she was admitted to our hospital. We treated her with 14 courses of S-1 and docetaxel combination therapy administered over 13 months. The lung metastasis was decreased for a period. Furthermore, radiofrequency ablation under computed tomography was performed against the lung metastasis re-growth at another hospital. Although the lung metastasis increased in size, no further metastases were detected during the clinical course. The patient was treated with radiotherapy for the lung metastasis re-growth. The tumor had almost disappeared by 10 months after the completion of radiotherapy. Currently, she is receiving palliative care as an outpatient and the lung metastasis has not been evident for 2 years since the completion of radiotherapy.
Abstract 3850: CDKN2a deficiency exposes a requirement for RhoA in maintenance of non-small cell lung cancer (2011)

Abstract Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related death world-wide. Tumorigenesis is a multistep process that involves several genetic aberrations. For example, K-RAS (onc-K-RAS), the most commonly mutated oncogene in human cancer, is expressed in about 25% of NSCLC. In addition, NSCLC often carry mutations or epigenetic modifications that affect the expression of the CDKN2a locus, which comprises the p16INK4a and the p14ARF (p19ARF in mice) tumor suppressor genes, which in turn regulate the retinoblastoma and the p53 tumor suppressor pathways. NSCLC tumorigenesis is faithfully recapitulated in transgenic mice where onc-K-Ras expression invariably induces adenomas and, after a long latency, adenocarcinomas. To characterize the consequence of concomitant onc-K-RAS expression and CDKN2a inactivation, we generated p16CDK4/p19ARF null mice expressing onc-K-Ras in the respiratory epithelium. We determined that Cdkn2a deficiency promotes rapid progression of lung adenomas to adenocarcinomas, which display aggressive features. We determined the status of activation of oncogenic signaling networks downstream of onc-K-Ras with phosphospecific antibodies and by expression profiling. We discovered that NSCLC that arises in CDKN2A deficient mice display dysregulation of RhoA, a small GTPase implicated in the regulation of the cytoskeleton, cell adhesion, and motility of cancer cells in culture. These activities are pertinent to tumorigenesis, however it is not known whether RhoA plays a role in the maintenance of established tumors. Surprisingly, we determined that RhoA is required for the survival of NSCLC derived lines expressing onc-K-RAS and deficient for either INK4a or the p53 tumor suppressor both when cultured in vitro and as xenografts in vivo. Cell death was due to a proapoptotic program and was accompanied by disruption of the cytoskeleton. Moreover, by performing loss and gain of function experiments we identified focal adhesion kinase (FAK) protein as the principal downstream target of RhoA responsible for this effect. Experiments in vivo with specific inhibitors are ongoing and will be presented at the meeting. Our findings reveal a previously unappreciated context dependent requirement of the RhoGTPase to maintain viability of established NSCLC. We propose that RhoA and its signaling network are novel therapeutic targets in NSCLC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3850. doi:10.1158/1538-7445.AM2011-3850
Simultaneous laser-based refractive index and absorbance determinations within micrometer diameter capillary tubes (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSimultaneous laser-based refractive index and absorbance determinations within micrometer diameter capillary tubesDarryl J. Bornhop and Norman J. DovichiCite this: Anal. Chem. 1987, 59, 13, 1632–1636Publication Date (Print):July 1, 1987Publication History Published online1 May 2002Published inissue 1 July 1987https://pubs.acs.org/doi/10.1021/ac00140a011https://doi.org/10.1021/ac00140a011research-articleACS PublicationsRequest reuse permissionsArticle Views276Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Genotoxicity of Different Nanocarriers: Possible Modifications for the Delivery of Nucleic Acids (2013)

The prevention of cyto-and genotoxicity of nanocarriers is an important task in nanomedicine.In the present investigation, we, at the first time using similar experimental conditions, compared genotoxicity of nanocarriers with different composition, architecture, size, molecular weight and charge.Poly(ethylene glycol) polymers, neutral and cationic liposomes, micelles, poly(amindo amine) and poly(propyleneimine) dendrimers, quantum dots, mesoporous silica, and supermagnetic iron oxide (SPIO) nanoparticles were studied.All nanoparticles were used in noncytotoxic concentrations.However, even in these concentrations, positively charged cationic liposomes, dendrimers, and SPIO nanoparticles induced genotoxicity leading to the significant formation of micronuclei in cells.Negatively charged and neutral nanocarriers were not genotoxic.A strong positive correlation was found between the number of formed micronuclei and the positive charge of nanocarriers.We proposed modifications of both types of dendrimers and SPIO nanoparticles that substantially decreased their genotoxicity and allowed for an efficient intracellular delivery of nucleic acids.
Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders (2018)

Abstract Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried out the largest GWAS to date of DSM - IV diagnosed AD. Genome - wide data on 14,904 individuals with AD and 37,944 controls from 28 case / control and family - based studies were meta - analyzed, stratified by genetic ancestry (European, N = 46,568; African; N = 6,280). Independent, genome - wide significant effects of different ADH1B variants were identified in European (rs1229984; p = 9.8E - 13) and African ancestries (rs2066702; p = 2.2E - 9). Significant genetic correlations were observed with schizophrenia, ADHD, depression, and use of cigarettes and cannabis. There was only modest genetic correlation with alcohol consumption and inconsistent associations with problem drinking. The genetic underpinnings of AD only partially overlap with those for alcohol consumption, underscoring the genetic distinction between pathological and non - pathological drinking behaviors.
Iodocyclization of O-(3-Cyclohexenyl)thiocarbamidates. An Unexpected Approach to Vicinal cis-Aminocyclohexenols (2000)

An unprecedented and unexpected iodocyclization of O-(3-cyclohexenyl)thiocarbamidates 2a-c to diiodides 7a-c, followed by alkaline hydrolysis and iodide elimination, has uncovered an alternative approach to vicinal cis-aminocyclohexenols 10a-c and 11a-c. This represents a new approach to these interesting building blocks.
Revision Total Knees Done for Extensor Problems Frequently Require Reoperation (2005)

Therapeutic study, Level-IV-1 (case series). See the Guidelines for authors for a complete description of levels of evidence.
Nucleotide Sequence of Part of the Simian Virus 40 Hind‐D Restriction Fragment (1978)

The nucleotide sequence at the beginning of the restriction fragment Hind-D from Simian virus 40 DNA has been derived by partial chemical degradation of (5'-32P)-labeled restriction fragments followed by analysis on polyacrylamide gel according to Maxam and Gilbert [Proc. Natl Acad. Sci. U.S.A. 74, 560-564 (1977)]. The sequence reported here is 140 nucleotides long. It contains an ATG codon which presumably corresponds to the initiator codon of the VP2 protein. This codon is preceded by an untranslated region which shows several interesting features, such as an alternation of (dA+dT)-rich and (dG+dC)-rich blocks.
ChemInform Abstract: Tetrahydrothienopyridine Derivatives as Novel GPIIb/IIIa Antagonists. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Routing for RPL Leaves (2020)

This specification leverages 6LoWPAN ND to provide a unicast and
multicast routing service in a RPL domain to 6LNs that do not
participate to RPL.
Thermal design for high-temperature high-irradiance testing of space solar panel components (2013)

Emcore has been performing High Intensity High Temperature (HIHT) tests on covered, interconnected cell (CIC) assemblies. End-of-life performance of spacecraft solar panels depends to a great extent on changes in the optical properties of the CICs' coverglass adhesive during the mission. An important change in silicone coverglass adhesives is observed as degradation of short wavelength transmission, often called “darkening” or “yellowing”. This is understood to be driven by exposure to high intensity UV and by exposure to elevated temperature. Solar panels on the Solar Probe Plus (SPP) spacecraft will be exposed to both high UV irradiance and elevated temperature over the course of a long mission. This paper reports on the thermal-mechanical design work performed and planned by Emcore in order to test CICs designed for SPP under these extreme conditions. Three types of thermal test designs are presented: conduction/convection with a single fixed temperature, thermal radiation with multiple fixed temperatures, and thermal radiation with a variable single temperature. We present some detail from predictive thermal models used in the test designs along with temperature data measured during the test runs.
MEMS-based Variable Capacitor for Millimeter-Wave Applications (2000)

We have demonstrated a MEMS-based variable capacitor with outstanding RF performance acceptable for millimeter-wave applications. Actuators were used to move the MEMS capacitor plate vertically to change the air gap between the MEMS plate and the signal line of a coplanar waveguide (CPW). The air gap change resulted in a capacitance change with a ratio of 2.7: 1. The MEMSbased capacitor achieved a very impressive quality factor (Q) that was close to 300 at 0.1 pF and 10 GHz. In addition, the capacitance showed no resonance and the equivalent resistance was less than 0.5 R in the frequency range up to 40 GHz. The assembly technology and the RF and actuator designs critical to the capacitor demonstration are discussed.
Rapid evolution of A(H5N1) influenza viruses after intercontinental spread to North America (2022)

Abstract Highly pathogenic avian influenza A(H5N1) viruses of clade 2.3.4.4b underwent an explosive geographic expansion in 2021, with the viruses being detected in wild birds and domestic poultry across Asia, Europe, and Africa. In 2022, viruses of this clade were detected in North America, signifying further intercontinental spread. Here, we show that the western movement of clade 2.3.4.4b was quickly followed by reassortment with local circulating viruses, resulting in the acquisition of novel polymerase gene cassettes. These reassortant A(H5N1) viruses are genotypically and phenotypically diverse, with many causing severe disease with dramatic neurologic involvement, in mammals. The proclivity of the current A(H5N1) 2.3.4.4b virus lineage to reassort and target the central nervous system warrants concerted planning to combat the spread and evolution of the virus within the continent and to mitigate the impact of a potential influenza pandemic that could originate from similar A(H5N1) reassortants.
Acidic FGF Expression in the Surroundings of Senile Plaques. (1994)

Immunohistochemical examination of postmortem brain tissue of Alzheimer's disease revealed that acidic fibroblast growth factor (aFGF) was specifically expressed in a subpopulation of reactive astrocytes which were congregated at the margin of the senile plaque. Double immunostaining indicated that such upregulation of aFGF expression might be related to the presence of reactive microglia rather than beta-amyloid protein deposits. Although, on the other hand, immunohistochemical staining for fibroblast growth factor receptor-1 occurred in some cortical neurons of Alzheimer's disease, the staining pattern did not differ from that in age-matched controls. Possible significance of aFGF-positive astrocytes in the surroundings of the senile plaque will be discussed in relation to receptor mediated or non-mediated mechanisms.