gebhart/patrepeval huggingface dataset:
A genome survey of Moniliophthora perniciosa gives new insights into Witches' Broom Disease of cacao (2008)

This genome survey gives an overview of the M. perniciosa genome, and reveals that a significant portion is involved in stress adaptation and plant necrosis, two necessary characteristics for a hemibiotrophic fungus to fulfill its infection cycle. Our analysis provides new evidence revealing potential adaptive traits that may play major roles in the mechanisms of pathogenicity in the M. perniciosa/cacao pathosystem.
Advanced motion control by multi-sensor based disturbance observer (2006)

Motion control has been widely used in industry applications. One of the key technologies of motion control is a disturbance observer, which quarries a disturbance torque of a motion system and realizes a robust acceleration control. The disturbance observer can observe and suppress the disturbance torque within its bandwidth. Recent motion systems begin to spread in the society and they are required to have ability to contact with unknown environment. Such a haptic motion requires much wider bandwidth. However, since the conventional disturbance observer attains the acceleration response by the second order derivative of position response, the bandwidth is limited due to the derivative noise. This paper proposes a novel structure of a disturbance observer. The proposed disturbance observer uses an acceleration sensor for enlargement of bandwidth. Generally, the bandwidth of an acceleration sensor is from 1 Hz to more than 1 kHz. To cover DC range, the conventional position sensor based disturbance observer is integrated. Thus, the performance of the proposed multi-sensor based disturbance observer (MSDO) is superior to the conventional one. The MSDO is applied to position control (infinity stiffness) and force control (zero stiffness). The numerical and experimental results show viability of the proposed method
A 6800-μm2 Resistor-Based Temperature Sensor in 180-nm CMOS (2018)

A resistor-based temperature sensor has been realized in 180 nm CMOS for SoC thermal management applications. Occupying only 6800 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , it is the smallest resistor-based temperature sensor ever reported. This is achieved by employing a compact highly-digital VCO-based ADC. After a 2-point trim, the sensor achieves an inaccuracy of ±0.35 °C (3σ) in a temperature range from -35 °C to 125 °C. By achieving a resolution of 0.12 °C (rms) at 2.8kSa/s, it can track the fast thermal-transients in SoCs.
The Growth and Tumor Suppressor NORE1A Is a Cytoskeletal Protein That Suppresses Growth by Inhibition of the ERK Pathway (2006)

NORE1A is a growth and tumor suppressor that is inactivated in a variety of cancers. NORE1A has been shown to bind to the active Ras oncogene product. However, the mechanism of NORE1A-induced growth arrest and tumor suppression remains unknown. Using anchorage-independent growth assays, we mapped the NORE1A effector domain (the minimal region of the protein responsible for its growth-suppressive effects) to the fragment containing the central and Ras association domains of NORE1A (amino acids 191-363). Expression of the NORE1A effector domain in A549 lung adenocarcinoma cells resulted in the selective inhibition of signal transduction through the ERK pathway. The full-length NORE1A (416 amino acids) and its fragments capable of growth suppression were localized to centrosomes and microtubules in normal and transformed human cells in a Ras-independent manner. A mutant that was deficient in binding to centrosomes and microtubules was also deficient in inducing cell cycle arrest. This suggests that cytoskeletal localization is required for growth-suppressive effects of NORE1A. Ras binding function was required for growth-suppressive effects of the full-length NORE1A but not for the growth-suppressive effects of the effector domain. Our studies suggest that association of NORE1A with cytoskeletal elements is essential for NORE1A-induced growth suppression and that the ERK pathway is a target for NORE1A growth-suppressive activities.
Mechanical and electrical characterization of self-sensing carbon black ECC (2011)

In this paper, the development of a new variation of Engineered Cementitious Composite (ECC) that aims to combine tensile ductility with self-sensing ability is described. ECC is a new type of high-performance fiber reinforced cementitious composite that exhibits strain-hardening under applied tensile load while resisting fracture localization. The self-sensing ability is achieved by incorporating a small dosage of carbon black (CB) into the ECC system (hereafter known as CB-ECC) to enhance its piezoresistive behavior while maintaining its tensile strain-hardening behavior. The tensile stress-strain response of CB-ECC is studied with an emphasis on its tensile stress and strain capacity, as well as its cracking pattern. In addition, the piezoresistive behavior of CB-ECC under uniaxial tension is investigated. Specifically, the effect of carbon black content on the electrical properties of ECC including the sensitivity of changes in its bulk conductivity under applied tensile strain are explored in detail.
Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver (2015)

Mitochondrial biogenesis is an essential process for cell viability. Mice with disruption of the growth hormone receptor (GHR) gene (Ghr gene) in the liver (LiGHRKO), in contrast to long-lived mice with global deletion of the Ghr gene (GHRKO), are characterized by lack of improved insulin sensitivity and severe hepatic steatosis. Tissue-specific disruption of the GHR in liver results in a mouse model with dramatically altered GH/IGF1 axis. We have previously shown increased levels of key regulators of mitochondrial biogenesis in insulin-sensitive GHRKO mice. The aim of the present study is to assess, using real-time PCR, the gene expression of key regulators of mitochondrial biogenesis (Pgc1α, Ampk, Sirt1, Nrf2 and Mfn2) and a marker of mitochondrial activity (CoxIV) in brains, kidneys and livers of male and female LiGHRKO and wild-type (WT) mice. There were significant differences between males and females. In the brain, expression of Pgc1α, Ampk, Sirt1, Nrf2 and Mfn2 was lower in pooled females compared to pooled males. In the kidneys, expression of Ampk and Sirt1 was also lower in female mice. In the liver, no differences between males and females were observed. Sexual dimorphism may play an important role in regulating the biogenesis of mitochondria.
In vivo assessment of lymph nodes using quantitative ultrasound on a clinical scanner: A preliminary study (2022)

Quantitative ultrasound (QUS) methods evaluating the backscattered echo signal provide a means to infer the microstructural properties of soft tissues. High-frequency (≥20 MHz) QUS has been used to detect metastases in excised human lymph nodes (LNs), but limited evidence exists about the efficacy of conventional-frequency QUS for characterizing LNs in vivo using a standard clinical scanner. In this study, 11 LNs from 11 patients with known primary tumors were scanned in vivo using a GE Logiq E9 scanner with a 10-MHz linear array. Metastatic status was determined by fine needle aspiration. Echo frames were processed using QUS methods to compute five parameters from the backscattered echo power spectrum and four from histograms of the echo envelope values. The spectral slope was found to be significantly higher in metastatic nodes (p &amp;lt; 0.001), whereas benign nodes exhibited significantly lower values of spectral intercept (p &amp;lt; 0.001), midband fit (p = 0.004), scatterer diameter (ESD, p &amp;lt; 0.001), and acoustic concentration (EAC, p = 0.003). A linear discriminator operating on ESD and EAC correctly differentiated benign and metastatic nodes with sensitivity of 0.89, specificity of 0.83, and area under the ROC curve of 0.91. These preliminary results demonstrate the feasibility of characterizing LNs in vivo at conventional frequencies using a clinical scanner.
Maximizing energy efficiency in off-peak hours: A novel sleep scheme for WLAN access points (2016)

The number of wireless access points (APs) have increased rapidly in recent years to support increasing demands of wireless local area network. However, some of the research findings show that many of these APs are actually idle mainly during off-peak hours, i.e., there is no active user to support within their coverage areas during that time. Nevertheless, to identify availability of users, all APs are remained powered-on always regardless the presence or absence of any active user inside their coverage areas. To save energy during off-peak hours in idle APs, sleep mechanism could be applied. In this paper, we propose a novel sleep mechanism for IEEE 802.11 wireless local area network APs. In our solution, an AP moves into sleep mode to maximize its energy efficiency (EE) while not harming traffic delay requirements. To decide length of sleep interval of an AP, we propose a dynamic sleep boundary decision algorithm which dynamically sets upper and lower bound of sleep duration considering traffic arrival rate and traffic delay requirements at a given time. Numerical results show the proposed scheme can improve EE of an AP significantly compared to the existing schemes without violating traffic delay requirements.
Expression of p210 and p190 BCR‐ABL due to alternative splicing in chronic myelogenous leukaemia (1998)

The hallmark of chronic myelogenous leukaemia (CML) is the presence of the Philadelphia chromosome and its resultant fusion message, BCR-ABL, and fusion protein, p210. Patients with CML in blast crisis, or with Philadelphia positive acute lymphoblastic leukaemia (ALL), can have a smaller BCR-ABL fusion transcript possessing only the first exon of BCR fused to ABL. This smaller transcript encodes a 190 kD protein which is more strongly transforming than the p210 protein derived from the larger CML-associated transcript. We performed RT-PCR on samples from CML patients in chronic phase to determine the frequency and mechanism of p190 and p210 co-expression and to see if this correlated with clinical indices. We examined the peripheral blood or marrow of 67 patients with CML and found that 35 of them expressed both transcripts whereas the remainder expressed the p210-encoding transcript exclusively. Additional PCR products of an intermediate size were also frequently detected and have been isolated and sequenced. Data from two of these products indicate that they are the result of alternative splicing and include variable combinations of BCR exons. We believe that the expression of the p190-encoding transcript in the chronic phase of CML is also due to alternative splicing. A comparison of patients co-expressing the p190- and p210-encoding transcripts with those patients who expressed only the p210-encoding transcript detected significantly higher white blood cell (WBC) counts and blast cell counts at time of testing as well as significantly higher white blood cell counts at diagnosis.
A quantitative assessment of the competition between water and anion oxidation at WO3 photoanodes in acidic aqueous electrolytes (2012)

The faradaic efficiency for O2(g) evolution at thin-film WO3 photoanodes has been evaluated in a series of acidic aqueous electrolytes. In 1.0 M H2SO4, persulfate was the predominant photoelectrochemical oxidation product, and no O2 was detected unless catalytic quantities of Ag+(aq) were added to the electrolyte. In contact with 1.0 M HClO4, dissolved O2 was observed with nearly unity faradaic efficiency, but addition of a hole scavenger, 4-cyanopyridine N-oxide, completely suppressed O2 formation. In 1.0 M HCl, Cl2(g) was the primary oxidation product. These results indicate that at WO3 photoanodes, water oxidation is dominated by oxidation of the acid anions in 1.0 M HCl, H2SO4, and HClO4, respectively.
A Multidimensional Investigation of the Effects of Publication Retraction on Scholarly Impact (2017)

During the past few decades, the rate of publication retractions has increased dramatically in academia. In this study, we investigate retractions from a quantitative perspective, aiming to answer two fundamental questions. One, how do retractions influence the scholarly impact of retracted papers, authors, and institutions? Two, does this influence propagate to the wider academic community through scholarly associations? Specifically, we analyzed a set of retracted articles indexed in Thomson Reuters Web of Science (WoS), and ran multiple experiments to compare changes in scholarly impact against a control set of nonretracted articles, authors, and institutions. We further applied the Granger Causality test to investigate whether different scientific topics are dynamically affected by retracted papers occurring within those topics. Our results show two key findings: first, the scholarly impact of retracted papers and authors significantly decreases after retraction, and the most severe impact decrease correlates with retractions based on proven, purposeful scientific misconduct; second, this retraction penalty does not seem to spread through the broader scholarly social graph, but instead has a limited and localized effect. Our findings may provide useful insights for scholars or science committees to evaluate the scholarly value of papers, authors, or institutions related to retractions.
Molecular Resists Based on Cholate Derivatives for Electron-Beam Lithography (2006)

We have designed and synthesized cholate derivatives [1,4-bis(methyloxymethylcholate)cyclohexane: C2ChDM and 1,2-bis(oxymethylcholate)ethane: C2E] to investigate their properties as chemically amplified (CA) positive-tone electron-beam (EB) resist materials (Fig. f1). C2ChDM and C2E which were easily obtained by one-step esterification from cholic acid and chloride compound, showed glass transition temperatures (Tgs) of 85 and 84 °C, respectively. These compounds were dissolved in propylene glycol monomethylether acetate (PGMEA) and formed amorphous thin films onto silicon wafers by a spin-coat method. The etch rates of C2ChDM and C2E, which were measured under CF4/CHF3/Ar mixed gas, were almost the same as poly( p-hydroxystyrene) (PHS). Model resist samples were formulated with C2ChDM and C2E as a base matrix and photo-acid generator (PAG) originating from a sulfonium salt (resist-A and -B, respectively). These resists showed good sensitivities to EB exposure. Furthermore, the FT-IR spectra of resist-A and -B films unexposed and exposed by the EB lithography tool were measured. From the spectral changes in resist-A and -B films, we confirmed that a cleavage of the ester bond occurred with EB irradiation and bake treatment, and that these resists worked as common CA positive-tone resists. The results with the resist-A and -B using EB exposure indicated a resolution of a 120 nm lines and spaces pattern.
Abstract CT306: Radiolabeled anti-PSMA antibody J591 immunotherapy is associated with favorable circulating tumor cell (CTC) count control in men with castration-resistant prostate cancer (2015)

Abstract Background: J591 is a monoclonal antibody that selectively binds to prostate-specific membrane antigen (PSMA). Prospective phase I and II trials with therapeutic radiolabeled 177Lu-J591 have shown favorable PSA decline rates. Additionally, our group has previously reported that non-invasive evaluation of PSMA expression by imaging with planar gamma camera imaging is associated with response and survival. Initial anecdotal experience showed declines in CTC counts which led to prospective study. Methods: Three clinical trials of 177Lu-J591 in men with metastatic CRPC have included prospective evaluation of CTC counts (CellSearch methodology) prior to and following therapy (single-dose 177Lu-J591, fractionated-dose 177Lu-J591, and fractionated-dose 177Lu-J591 + docetaxel). Based upon prior experience of J591-based therapy without an effector molecule as immunotherapy, and an anecdotal report of CTC count decline following a low (imaging) dose of J591 without an effector molecule, a cohort of patients who received J591 without 177Lu labeling was also retrospectively analyzed. Results: 44 pts unselected for PSMA expression received 177Lu-J591 therapy had prospectively measured CTC counts. 39 of 44 pts (88.6%) had imaging evidence of PSMA expression. 57% of pts had baseline unfavorable (≥ 5 cells/7.5 mL) CTC counts. Of overall evaluable pts, 72.4% had decline in CTC counts (7.5 to 100% decline), with 50% of those with unfavorable baseline counts converting to favorable counts at 4-6 weeks. 17.1% with undetectable CTC counts remained undetectable at follow up. 7 pts with mCRPC and elevated CTC counts who received low-dose (naked J591) prior to imaging were also identified, and 4 (57%) of these pts demonstrated CTC count decline. Conclusion: In addition to previously reported PSA declines, treatment with 177Lu-J591 is associated with favorable CTC count decline in men with metastatic CRPC. Infusion with unlabeled J591 may also lead to CTC count clearance. Based on this finding, we are planning a prospective clinical trial with unlabeled (naked) J591 in men with metastatic CRPC and unfavorable CTC counts. Citation Format: Pravin Date, Beerinder S. Karir, Jaspreet S. Batra, Yuliya Jhanwar, Himisha Beltran, David M. Nanus, Neil H. Bander, Scott T. Tagawa. Radiolabeled anti-PSMA antibody J591 immunotherapy is associated with favorable circulating tumor cell (CTC) count control in men with castration-resistant prostate cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr CT306. doi:10.1158/1538-7445.AM2015-CT306
Titania-supported molybdenum oxide combined with Au nanoparticles as a hydrogen-driven deoxydehydration catalyst of diol compounds (2022)

The first molybdenum-based heterogeneous deoxydehydration catalyst using H 2 as a reducing agent was developed, while typical deoxydehydration systems use more expensive rhenium as the active center.
Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung (1997)

Lung carcinoids occur sporadically and rarely in association with multiple endocrine neoplasia type 1 (MEN1). There are no well defined genetic abnormalities known to occur in these tumors. We studied 11 sporadic lung carcinoids for loss of heterozygosity (LOH) at the locus of the MEN1 gene on chromosome 11q13, and for mutations of the MEN1 gene using dideoxy fingerprinting. Additionally, a lung carcinoid from a MEN1 patient was studied. In four of 11 (36%) sporadic tumors, both copies of the MEN1 gene were inactivated. All four tumors showed the presence of a MEN1 gene mutation and loss of the other allele. Observed mutations included a 1 bp insertion, a 1 bp deletion, a 13 bp deletion and a single nucleotide substitution affecting a donor splice site. Each mutation predicts truncation or potentially complete loss of menin. The remaining seven tumors showed neither the presence of a MEN1 gene mutation nor 11q13 LOH. The tumor from the MEN1 patient showed LOH at chromosome 11q13 and a complex germline MEN1 gene mutation. The data implicate the MEN1 gene in the pathogenesis of sporadic lung carcinoids, representing the first defined genetic alteration in these tumors.
Reducing silicon usage during technology development-a variance analysis approach (2002)

During the development of semiconductor process flows, various process and device design alternatives must be evaluated to allow identification of the best candidate flow. In a development fab, this comparison is made in the presence of inherent manufacturing variation together with the variation associated with changes such as aggressive lithographic scaling and adoption of new unit processes. In this environment of high process variability, it is difficult to identify the best performance recipe from a set of candidate recipes. The problem is further exacerbated by the need to minimize silicon usage to lower development costs. In this paper, we describe a method to enhance the ability to detect the impact of design alternatives on device performances. The method uses simple statistical concepts to first account for and then adjust for the various sources of variation. The approach has two advantages. First, it significantly reduces the amount of silicon required for recipe comparison. The method allows us to evaluate flows based on as little as half- or quarter-wafer allocation without compromising experimental resolution. Second, the approach decouples the problem of evaluating design alternatives for performance improvement from the problem of controlling the higher variation associated with new processes. Once a good candidate recipe has been identified with the proposed method, it may be transferred to a more expensive but tightly controlled fab for volume production.
Investigations of optical activity of natural products and chiral pharmaceuticals using liquid crystal technologies (2009)

In this article we demonstrate the use of liquid crystal technologies in the determination of enantiomeric excess and in the sensing of molecular chirality, particularly at values near to zero. We use this technique to investigate the optical purities of the commercially available chiral natural product, menthol, and in the investigation of the optical activity of racemic ibuprofen.
Properties of Five Toughened Matrix Composite Materials (1992)

The use of toughened matrix composite materials offers an attractive solution to the problem of poor damage tolerance associated with advanced composite materials. In this study, the unidirectional laminate strengths and moduli, notched (open-hole) and unnotched tension and compression properties of quasi-isotropic laminates, and compression-after-impact strengths of five carbon fiber/toughened matrix composites, IM7/E7T1-2, IM7/X1845, G40-800X/5255-3, IM7/5255-3, and IM7/5260 have been evaluated. The compression-after-impact (CAI) strengths were determined primarily by impacting quasi-isotropic laminates with the NASA Langley air gun. A few CAI tests were also made with a drop-weight impactor. For a given impact energy, compression after impact strengths were determined to be dependent on impactor velocity. Properties and strengths for the five materials tested are compared with NASA data on other toughened matrix materials (IM7/8551-7, IM6/1808I, IM7/F655, and T800/F3900). This investigation found that all five materials were stronger and more impact damage tolerant than more brittle carbon/epoxy composite materials currently used in aircraft structures.
Outcomes of Transvenous Lead Extraction for Cardiovascular Implantable Electronic Device Infections in Patients With Prosthetic Heart Valves (2016)

Transvenous lead extraction seems safe and curative in patients with CIED infection and prosthetic valves. Cure of infection can be achieved in the majority of patients with complete CIED removal and antimicrobial therapy and without valve surgery.
Transcatheter Heart Valve Crimping and Expansion: Commentary (2017)

Bovine pericardium represents the material of choice to serve as leaflets but this material is fragile and mishandling might lead to dramatic consequences. The complete innocuousness of handling at implantation has not been reached as crimping and balloon inflation cause various degrees of injury. These can impair the physical characteristics and aggravate the thrombogenicity. The design of the device must promote the long-term durability of the pericardium. The role and selection of polyester fabrics as buffer between the metallic frame and the pericardium is likely to prevent major abrasion at implantation and in situ.