gebhart/patrepeval huggingface dataset:
A low-loss 5GHz bandpass filter using HTS coplanar waveguide quarter-wavelength resonators (2003)

A novel low-loss high temperature superconductor (HTS) filter is proposed by using coplanar waveguide quarter-wavelength resonators. A 4-pole Chebyshev bandpass filter with a center frequency 5.0GHz and a 0.01dB-ripple fractional bandwidth 3.2% is designed and fabricated using a YBCO film deposited on a MgO substrate. The frequency response of the filter measured at 60K agrees very well with the theoretical prediction. The measured insertion loss is 0.22dB, the lowest reported so far for HTS coplanar waveguide filters.
Mixing mechanism in a two-dimensional bubble column (2018)

A large-scale model for transport by secondary open wakes is proposed to describe the spatiotemporal evolution of the concentration field in a homogeneous bidimensional bubble swarm rising at high Reynolds number.
Sensor Systems for Regenerative Life Support Systems (1992)

&lt;div class="htmlview paragraph"&gt;Successful operation of life support systems for space exploration missions of the future will require unique sophisticated sensor systems for highly dependable operation, i.e., autonomous and fault tolerant. These sensor systems will require the use of multifunctional in situ sensors that are strategically located throughout the life support systems. These sensors will communicate through control loops that are hierarchically interconnected at several levels of the life support system. Development of the sensor system must be done synergistically with the integration and testing of the subsystems, and their process units, as they are assembled and tested. The plan for proceeding with the sensor systems development and the integration with the test bed assembly and operation is described in this paper.&lt;/div&gt;
Looking at the Cost: Using Flow Analysis to Assess and Improve Chemical Production Processes (2012)

Abstract Identifying process alternatives to reduce the cost of product manufacturing is a key objective in process development and optimization. This article starts out by presenting the fundamental principles of flow‐based analysis methods. Material and energy flow analysis, with cost flow added, is then applied to chemical process development. An example shows that the method of charging cost to the flows that exit the production steps influences the recognizability of the cost reduction options. A more thorough analysis and understanding would be beneficial as a basis for identifying best‐practice recommendations. For industrial use, the suitability of existing cost flow analysis tools could be improved by enabling the use of a variety of allocation methods, data exchange with standard tools in process engineering, and improved user interfaces.
XXI century gigascale integration (GSI): the interconnect problem (1999)

Summary form only given, as follows. From the inception of microelectronics in 1959 until the early 1990's, transistors dominated both the performance and cost of microchips while interconnects were of secondary importance. In recent years, this hegemony has reversed itself. Interconnects now tend to dominate microchip performance and cost with transistors relegated to the secondary role. As an example, for late 1980's 1.0 /spl mu/m technology, the intrinsic switching delay of an unloaded MOSFET approaches 10 ps while the response time of a 1.0 mm interconnect is approximately 1 ps. But, for early 2000's 0.1 /spl mu/m technology, the intrinsic delay of a MOSFET decreases to about 1.0 ps while the response time of a 1.0 mm interconnect increases to 100 ps. Concurrent with this signal wiring dilemma, clock frequency is increasing by 100X placing stringent new demands on the chip clock distribution network. Supply current is increasing by 60X while supply voltage scales downward by 5X thereby imposing a huge new burden on the power distribution network. Maximum total wire length per chip increases by 50X, while chip-to-package input-output interconnect count increases by 10X. The profound and pervasive nature of the interconnect problem demands a response. The central thesis of this response is that early XXI century opportunities for GSI will be governed by an interconnect dominated hierarchy of theoretical and practical limits whose five levels are codified as fundamental, material, device, circuit and system. Systematic exploration of this hierarchy of limits reveals salient opportunities for addressing the interconnect problem.
Buschke Löwenstein Tumor of the Right Lower Abdominal Wall: Case Report and Review of the Literature (2015)

Buschke-Löwenstein tumor (BLT), known as giant condyloma acuminatum (GCA), is a very rare disease that typically appears as a penile lesion but can although appear in the anogenital region, bladder, vulva, scrotum and sacrococcygeal area as well. Despite of its histologically benign signs, a high recurrence rate, invasiveness and destructive growth characterizes this rare disease as clinically malignant. Malignant transformation into verrucous carcinoma (VC) and squamous-cell carcinoma (SCC) have been described as well. Many treatment modalities inclusive neoadjuvant radio-and chemotherapy and topical treatment have been reported but due to lack of controlled studies no treatment can be recommended. We present a case of Buschke-Löwenstein tumor involving the right lower abdominal wall of the colostomy region at a 71 years old male. To our knowledge, we first describe a case report of GCA involving abdominal wall at the colostomy region, successfully treated by wide radical excision and plastic reconstruction.
Supplementary Figure 3 from Small-Molecule RA-9 Inhibits Proteasome-Associated DUBs and Ovarian Cancer <i>In Vitro</i> and <i>In Vivo</i> via Exacerbating Unfolded Protein Responses (2023)

&lt;p&gt;PDF file - 732KB, UPR stress levels in ovarian surface epithelial cells (OSEs).&lt;/p&gt;
Effects of Voriconazole on Cryptococcus neoformans (2004)

Voriconazole is a broad-spectrum triazole that offers extended activity against molds and yeasts that are not susceptible to earlier azole-type drugs. Recent studies indicate that melanization can severely reduce the susceptibility of certain antifungal drugs, but there is no information as to whether voriconazole is vulnerable to this effect. The activity of voriconazole on C. neoformans was assessed by MIC analysis and time-kill assays for melanized and nonmelanized cells. Cell morphology, capsule release, and phagocytosis of C. neoformans were studied in the presence or absence of subinhibitory concentrations of voriconazole. Voriconazole was fungicidal at concentrations of >/=8 microg/ml in vitro against the strains of C. neoformans examined, and its efficacy was not diminished by melanization. Cells grown in subinhibitory concentrations of voriconazole had smaller cellular and capsular volumes than cells grown in the absence of drug. The induction of the capsule by serum was not affected by voriconazole. Cells grown in subinhibitory concentrations of voriconazole released their capsule and were phagocytosed at rates comparable with yeast grown without the antifungal. The high activity of voriconazole against both melanized and nonmelanized cells results suggest that voriconazole may be a particularly valuable drug for cryptococcosis.
Supplementary Table 1 from Reprogramming Tumor-Infiltrating Dendritic Cells for CD103<sup>+</sup>CD8<sup>+</sup> Mucosal T-cell Differentiation and Breast Cancer Rejection (2023)

&lt;p&gt;PDF file - 37K, Supplementary Table 1. Primary breast tumor samples were received from Baylor University Medical Center.&lt;/p&gt;
Influence of the hierarchical architecture of multi-core iron oxide nanoflowers on their magnetic properties (2023)

Magnetic properties of superparamagnetic iron oxide nanoparticles are controlled mainly by their particle size and by their particle size distribution. Magnetic properties of multi-core iron oxide nanoparticles, often called iron oxide nanoflowers (IONFs), are additionally affected by the interaction of magnetic moments between neighboring cores. The knowledge about the hierarchical structure of IONFs is therefore essential for understanding the magnetic properties of IONFs. In this contribution, the architecture of multi-core IONFs was investigated using correlative multiscale transmission electron microscopy (TEM), X-ray diffraction and dynamic light scattering. The multiscale TEM measurements comprised low-resolution and high-resolution imaging as well as geometric phase analysis. The IONFs contained maghemite with the average chemical composition [Formula: see text]-Fe[Formula: see text]O[Formula: see text]. The metallic vacancies located on the octahedral lattice sites of the spinel ferrite structure were partially ordered. Individual IONFs consisted of several cores showing frequently a specific crystallographic orientation relationship between direct neighbors. This oriented attachment may facilitate the magnetic alignment within the cores. Individual cores were composed of partially coherent nanocrystals having almost the same crystallographic orientation. The sizes of individual constituents revealed by the microstructure analysis were correlated with the magnetic particle sizes that were obtained from fitting the measured magnetization curve by the Langevin function.
Levosimendan-Induced Venodilation is Mediated by Opening of Potassium Channels (2021)

Unique vascular responses adhere to the cardiovascular efficacy of the inodilator levosimendan. In particular, selective venodilation appears to explain its clinical benefit during pulmonary hypertension complicated by heart failure with preserved ejection fraction. Vasodilators increase vessel diameter in various parts of the vascular system to different degrees and thereby influence blood pressure, its distribution, and organ perfusion depending on their mechanisms of action. Levosimendan and its long-lived active metabolite OR-1896 mobilize a set of vasodilatory mechanisms, that is, the opening of the ATP-sensitive K<sup>+</sup> channels and other K<sup>+</sup> channels on top of a highly selective inhibition of the phosphodiesterase III enzyme. A vessel-specific combination of the above vasodilator mechanisms-in concert with cardiac effects and cardiovascular reflex regulations-illustrates the pharmacological profile of levosimendan in various cardiovascular disorders. While levosimendan has been known to be an inotrope, its properties as an activator of ATP-sensitive K<sup>+</sup> channels have gone largely ignored with respect to clinical applications. Here, we provide a summary of what is known about the ATP-sensitive K<sup>+</sup> channel properties in preclinical studies and now for the first time, its ATP-sensitive K<sup>+</sup> channel properties in a clinical trial.
Modern developments in electron-beam fluorescence (1991)

Recent developments in the area of electron-beam fluorescence are discussed with special attention given to the experience in the use of the electron-beam fluorescence in flight research. A new measurement approach, called electron-photon fluorescence (EPF), is described, and it is shown that EPF offers the potential of overcoming some of the disadvantages of electron-beam fluorescence in high-density flows. Examples of using the EPF technique are presented.
Nonradiative recombination processes of carriers in InGaN/GaN probed by the microscopic transient lens spectroscopy (2003)

Temporally and spatially resolved observations of the nonradiative recombination (NR) processes of carriers in low dislocated GaN and InGaN/GaN were successfully obtained by using microscopic transient lens spectroscopy. The heat generations and conductivities of NR processes were detected by the signal intensities and the time profiles. We found that the thermal conductivities were not so different at the seed region (threading dislocation density (TDD)=1–2×109 cm−2) and the wing region (TDD=1–2×106 cm−2) of air-bridged lateral epitaxially grown GaN and InGaN/GaN, but the amount of heat generated at the wing regions was much smaller than that at the seed regions.
HDR IMAGE QUALITY ASSESSMENT USING MACHINE-LEARNING BASED COMBINATION OF QUALITY METRICS (2018)

We present a Full-Reference Image Quality Assessment (FR-IQA) approach to improve High Dynamic Range (HDR) IQA by combining results from various quality metrics (HDR-CQM). To combine these results, we apply linear regression and various machine learning techniques such as multilayer perceptron, random forest, random trees, radial basis function network and support vector machine (SVM) regression. We found that using a non-linear combination of scores from different quality metrics using SVM is better at prediction than the other techniques. We use the Sequential Forward Floating Selection technique to select a subset of metrics from a list of quality metrics to improve performance and reduce complexity. We demonstrate improved performance using HDR-CQM as compared to a number of existing IQA metrics. We find that our HDR-CQM metric comprised of only four metrics can obtain statistically significant improvement over HDR video quality measure (HDR-VQM), the best performing individual IQA metric for HDR still images.
Fabrication of ultra-flexible, ultra-thin organic field-effect transistors and circuits by a peeling-off method (2013)

We present a new and simple way of fabricating ultra-thin and flexible organic field-effect transistors and circuits by directly peeling them off from conventional SiO2 substrates. The devices show excellent flexibility up to a bending radius of 1 mm. Free-standing OFETs as thin as about 600 nm can also be made in this way. In addition, flexible complementary inverters with a gain of 100 can be fabricated by the peeling-off method.
An Efficient Unnatural Base Pair for PCR Amplification (2007)

Expansion of the genetic alphabet by an unnatural base pair system provides a powerful tool for modern biotechnology. As an alternative to previous unnatural base pairs, we have developed a new pair between 7-(2-thienyl)imidazo[4,5-b]pyridine (Ds) and 2-nitropyrrole (Pn), which functions in DNA amplification. Pn more selectively pairs with Ds in replication than another previously reported pairing partner, pyrrole-2-carbaldehyde (Pa). The nitro group of Pn efficiently prevented the mispairing with A. High efficiency and selectivity of the Ds-Pn pair in PCR amplification were achieved by using a substrate mixture of the gamma-amidotriphosphate of Ds and the usual triphosphates of Pn and the natural bases, with Vent DNA polymerase as a 3' to 5' exonuclease-proficient polymerase. After 20 cycles of PCR, the total mutation rate of the Ds-Pn site in an amplified DNA fragment was approximately 1%. PCR amplification of DNA fragments containing the unnatural Ds-Pn pair would be useful for expanded genetic systems in DNA-based biotechnology.
Ambulance dispatch calls attributable to influenza A and other common respiratory viruses in the Netherlands (2014‐2016) (2020)

High urgency ambulance dispatches reflect the burden of different respiratory viruses and might be useful to monitor the respiratory season overall. Influenza plays a smaller role than other viruses: RSV is important in children while adenovirus and hMPV are the biggest contributors to emergency calls in the elderly.
Performance Analysis of IEEE 802.11ac DCF with Hidden Nodes (2012)

Recently, the IEEE 802.11 standard based Wireless Local Area Networks (WLAN) have become more popular and are widely deployed. It is anticipated that WLAN will play an important rule in the future wireless communication systems in order to provide several gigabits data rate. IEEE 802.11ac is one of the ongoing WLAN standard aiming to support very high throughput (VHT) with data rate of up to 6 Gbps below the 6 GHz band. In the development of IEEE 802.11ac standard, several new physical layer (PHY) and medium access control layer (MAC) features are taken into consideration, such as employing wider bandwidth in PHY and incrementing the limits of frame aggregation in MAC. However, due to the newly introduced features, some traditional techniques used in previous standards could face some problems. This paper presents a performance analysis of 802.11ac Distributed Coordination Function (DCF) in presence of hidden nodes in overlapping BSS (OBSS) environment. The effectiveness of DCF in IEEE 802.11ac WLAN when using different primary channels and different frequency bandwidth has also been discussed. Our results indicate that the traditional RTS/CTS handshake mechanism faces shortcomings and needs to be modified in order to support the newly defined 802.11ac amendment.
Use of long rods and a short arthrodesis for burst fractures of the thoracolumbar spine. A long-term follow-up study. (1994)

Thirteen patients who had a burst fracture of the thoracolumbar spine (the twelfth thoracic to the fifth lumbar vertebra) were managed with the use of long rods and a short arthrodesis (the so-called rod-long, fuse-short technique). The patients were followed for an average of seventy-four months (range, thirty-four to 118 months). Six months after the operation, the rods were removed and the fusion mass was explored. At that time, twelve patients had a solid fusion at all levels of the arthrodesis. Of the eighty-eight facet joints that had been spanned by the rods but had not been included in the arthrodesis, two had nevertheless progressed to fusion, as determined radiographically. Physiological motion was present in forty-three of the forty-four segments for which a fusion had not been intended. Before the operation, the average anterior height of the fractured vertebrae was 61 per cent of the estimated height before the injury; this improved after the operation to an average of 83 per cent (median, 87 per cent) of the height before the injury. At the latest follow-up examination, the anterior height was an average of 78 per cent of the estimated height before the injury (median, 82 per cent; range, 51 to 93 per cent), a slight decrease compared with the value immediately after the operation. Kyphosis of the injured segment before the operation, measured for twelve of the thirteen patients, averaged 15 degrees (median, 12 degrees; range, 0 to 33 degrees); as a result of the operation, this improved an average of 15 degrees, to 0 degrees of kyphosis.(ABSTRACT TRUNCATED AT 250 WORDS)
Optical characterization of surface-displacement fields of high-frequency transducers (2014)

This paper describes a non-contact optical technique to characterize surface-displacement fields of high-frequency transducers. We have developed an ultra-broadband (1 GHz), fine-resolution (0.5 microns), optical interferometer to map the displacement and pressure fields of high-frequency transducers beyond the limits of conventional hydrophones and laser vibrometers. Several transducers, including a 40-MHz annular array and a 100-MHz, zinc oxide (ZnO), focused transducer were characterized. The transducers were excited with an impulse, and their surface vibrations were detected using a Michelson interferometer. The surface of the transducer was raster scanned to map the 2D displacement amplitude and phase distributions. Transducer surface response was measured in air and compared to reference pulse-echo measurement on a glass slide in water. A high numerical aperture (NA = 0.55) optical lens was used to detect the vibrations from a 0.5-micron spot at each scan location in 100-μm raster-scan steps. The optically measured 6-dB bandwidth response and central frequency were in agreement with the pulse-echo measurements. We observed a minimum surface-displacement detection sensitivity of 100 fm/Hz <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1/2</sup> .
Elix (2019)

App links, also known as mobile deep links, are URIs that point to specific pages in an app. App links are essential to many mobile experiences: Google and Bing use them to link search results directly to relevant pages in an app and apps use them for cross-app navigation. However, app links are hard to discover and, since they must be explicitly built into apps by developers, only exist for a small fraction of apps. To address these two problems, we propose Elix, an automated app link extractor. We define link extraction as a static information flow problem where a link, with its scheme and parameters, is synthesized by analyzing the data flow between subsequent pages in an app. As static analysis is prone to false positives, Elix adopts a novel, path-selective taint analysis that leverages symbolic execution to reason about path constraints and abandon infeasible paths. Elix can automatically and correctly discover links that are exposed by an app, and many others that are not explicitly exposed, thus increasing coverage of both link-enabled apps and link-enabled pages in an app. Elix also simplifies the scheme of extracted links by reducing complex types to a minimal set of primitive types. We have implemented Elix on Android and applied it to 1007 popular Android apps. Elix can extract 80-90% of an app's links, and above 80% of the extracted links are stable.
InP/InGaAsP-Based Integrated 3-dB Trench Couplers for Ultra-Compact Coherent Receivers (2010)

We present the design, fabrication, and test results for ultra-compact 3-dB frustrated total internal reflection-based trench couplers in an InP/InGaAsP monolithic integration platform. The trench coupler is integrated with phase modulators and a balanced photodiode (BPD) pair to enable a 180° hybrid ultra-compact coherent receiver. Several trench splitter designs exhibit near 3-dB splitting with a loss of 3 dB. The BPD pair is used to characterize coherent mixing of two input optical signals into the trench splitter, and coherence efficiency of 75% is achieved.
“Dominant-Negative Effect” Mechanism in OPTNE478G-Linked Amyotrophic Lateral Sclerosis (S43.004) (2016)

Objective: Pathological protein inclusions containing OPTN are a common feature in neurodegenerative diseases, including ALS. OPTN primarily localizes to autophagosomes. Our data suggest that autophagic dysfunction is the key molecular event in OPTN-linked ALS. Background: OPTN mutations cause ALS in both autosomal recessive and autosomal dominant fashion, an uncommon phenomenon in genetic diseases. A convergent mechanism to explain this phenomenon is lacking. The dominant OPTNE478G mutation provides a clue to key mechanistic insight in the pathogenesis in OPTN-linked ALS, and possible in other forms of ALS as well, because OPTN protein aggregates have been shown to be a common pathological hallmark in vast majority of the ALS cases, except for SOD1-linked cases. Design/Methods: Expression constructs. The XhoI/BamHI fragment containing full-length wild-type OPTN, or OPTN-E478G was cloned into the pEGFP-N1 or pmCherry-C1 expression vectors (Clontech). We also co-transfected UBQLN2-GFP and GFP-LC3 (Addgene, 11546) with OPTN constructs. Cell culture, transfection, Western blot and confocal microscopy were performed. Results: In Neuro2A cells, we find that cells expressing OPTNE478G accumulate UbG76V-GFP (a UPS reporter substrate) and LC3 (an autophagosome-associated protein). Furthermore, LC3-positive autophagosomes fail to recruit mutant OPTN (confocal studies). Western blots showed decreased conversion of LC3-I to LC3-II, indicating disrupt autophagic function in OPTNE478G mutation. Wild-type OPTN would aggravate OPTNE478G-related autophasomal dysfunction in double transfected cell lysate. Conclusions: OPTNE478G, a well-established autosomal dominant ALS mutation, acts in a “dominant-negative effect” mechanism in the OPTNE478G-mediated ALS in our study. The OPTN-linked ALS appears to be the first neurodegenerative disorder showing a “dominant-negative effect’ in its pathogenesis. Further studies of the physiological functions of OPTN should provide key insights into the pathogenesis of motor neuron degeneration in ALS due to OPTN deficiency.