gebhart/patrepeval huggingface dataset:
Fabrication of Ordered Hollow ZnO–NiO Oxide Arrays (2011)

We have combined colloidal templating and pulsed laser deposition (PLD) to fabricate arrays of ordered two-dimensional hollow ZnO-NiO mixed oxides. The underlying principle involved in producing colloidal templates by a spin-coating method has been investigated with the use of radial distribution functions. To deposit mixed oxide in a facile manner, we have designed and fabricated a novel PLD target, which has an alternating sequence of pie-shaped ZnO and NiO pieces. Structural characterizations reveal a surface morphology of protruding nano-crystallites, which consist of würtzite ZnO and rock salt NiO. The electrical properties have been discussed from the viewpoint of junction effects.
Lower bounds on the anticipation of encoders for input-constrained channels (2001)

An input-constrained channel S is defined as the set of words generated by a finite labeled directed graph. It is shown that every finite-state encoder with finite anticipation (i.e., with finite decoding delay) for S can be obtained through state-splitting rounds applied to some deterministic graph presentation of S, followed by a reduction of equivalent states. Furthermore, each splitting round can be restricted to follow a certain prescribed structure. This result, in turn, provides a necessary and sufficient condition on the existence of finite-state encoders for S with a given rate p:q and a given anticipation a. A second condition is derived on the existence of such encoders; this condition is only necessary, but it applies to every deterministic graph presentation of S. Based on these two conditions, lower bounds are derived on the anticipation of finite-state encoders. Those lower bounds improve on previously known bounds and, in particular, they are shown to be tight for the common rates used for the (1,7)-runlength-limited (RLL) and (2,7)-RLL constraints.
Characterization of the cytoplasmic filament protein gene (cfpA) of Treponema pallidum subsp. pallidum (1996)

Treponema pallidum and other members of the genera Treponema, Spirochaeta, and Leptonema contain multiple cytoplasmic filaments that run the length of the organism just underneath the cytoplasmic membrane. These cytoplasmic filaments have a ribbon-like profile and consist of a major cytoplasmic filament protein subunit (CfpA, formerly called TpN83) with a relative molecular weight of approximately 80,000. Degenerate DNA primers based on N-terminal and CNBr cleavage fragment amino acid sequences of T. pallidum subsp. pallidum (Nichols) CfpA were utilized to amplify a fragment of the encoding gene (cfpA). A 6.8-kb EcoRI fragment containing all but the 5' end of cfpA was identified by hybridization with the resulting PCR product and cloned into Lambda ZAP II. The 5' region was obtained by inverse PCR, and the complete gene sequence was determined. The cfpA sequence contained a 2,034-nucleotide coding region, a putative promoter with consensus sequences (5'-TTTACA-3' for -35 and 5'-TACAAT-3' for -10) similar to the sigma70 recognition sequence of Escherichia coli and other organisms, and a putative ribosome-binding site (5'-AGGAG-3'). The deduced amino acid sequence of CfpA indicated a protein of 678 residues with a calculated molecular mass of 78.5 kDa and an estimated pI of 6.15. No significant homology to known proteins or structural motifs was found among known prokaryotic or eukaryotic sequences. Expression of a LacZ-CfpA fusion protein in E. coli was detrimental to survival and growth of the host strain and resulted in the formation of short, irregular filaments suggestive of partial self-assembly of CfpA. The cytoplasmic filaments of T. pallidum and other spirochetes appear to represent a unique form of prokaryotic intracytoplasmic inclusions.
Acute myocardial infarction elevates serine protease activity in saliva of patients with periodontitis (2011)

AMI may be reflected in PMN serine protease elastase activity in saliva, despite its strong association with periodontitis.
CAMEL Phase 4 (2006)

This chapter contains sections titled: General Call Control GPRS Control SMS Control Mobility Management Any-time Interrogation Subscription Data Control Mobile Number Portability Control of IP Multimedia Calls
Two unrelated patients with inversions of the X chromosome and non-specific mental retardation: physical and transcriptional mapping of their common breakpoint region in Xq13.1 (1999)

Two unrelated mildly retarded males with inversions of the X chromosome and non-specific mental retardation (MRX) are described. Case 1 has a pericentric inversion 46,Y,inv(X) (p11.1q13.1) and case 2 a paracentric inversion 46,Y,inv(X) (q13.1q28). Both male patients have severe learning difficulties. The same chromosomal abnormalities were found in their mothers who are intellectually normal. Fluorescence in situ hybridisation mapping showed a common area of breakage of each of the inverted chromosomes in Xq13.1 near DXS131 and DXS162. A detailed long range restriction map of the breakpoint region was constructed using YAC, PAC, and cosmid clones. We show that the two inverted chromosomes break within a short 250 kb region. Moreover, a group of ESTs corresponding to an as yet uncharacterised gene was mapped to the same critical interval. We hypothesise that the common inversion breakpoint region of the two cases in Xq13.1 may contain a new MRX gene.
A SAMPLE OBTAINING DEVICE (2020)

The present invention relates to a device and method for obtaining a sample from<br/>a patient.
"Drowned lung" following lobectomy and radiation therapy: a case report. (2003)

Radiation therapy for locoregional control of NSCLC is controversial, and risk factors for developing radiation associated pneumopathies must be assessed before any patient undergoes adjuvant radiation therapy. Radiotherapy for patients with early stage NSCLC may be associated with increased morbidity and decreased survival. As evidenced by our case, adjuvant radiation therapy for a patient with significant risk factors and early stage disease generated morbidity from the treatment itself. It contributed to development of a bronchopleural fistula and chronic empyema, and led to distortion and obstructing of the airway causing irreversible pulmonary consolidation ("drowned lung"). Further, the final pathology report showed clear margins, suggesting that there was no clear indication for radiation therapy. Although NSCLC, the potential risks cannot be overlooked and patients should be carefully evaluated before recommending postoperative therapy.
Intralesional Diode Laser 1064 nm for the Treatment of Hidradenitis Suppurativa: A Report of Twenty Patients (2018)

Intralesional diode laser 1064 nm can be a good treatment option for patients with moderate and localized hidradenitis suppurativa, because it is minimally invasive, doesn't have significant complications and provides a rapid post-treatment recovery.
Just Another Year in the Consumer Electronics Industry? [Notes from the Editor] (2015)

Welcome to another CES show issue of IEEE Conumer Electronics Magazine. This issue is aligned with the International CES held in Las Vegas, a global meeting for the consumer electronics (CE) industry where you can view the latest developments in new CE products and associated technologies and services. It is a time to reflect on the year gone by and to look forward to what is to come next in our industry.
Direct observation of the excited-state c i s–t r a n s photoisomerization of bacteriorhodopsin: Multilevel line shape theory for femtosecond dynamic hole burning and its application (1989)

A dynamic hole-burning study of light-adapted bacteriorhodopsin (BR568) using 6 fs optical pulses has recently been reported [R. A. Mathies, C. H. Brito Cruz, W. T. Pollard, and C. V. Shank, Science 240, 777 (1988)]. The temporal evolution of the excited state absorption and emission spectra after excitation with 60 fs pulses provides a direct observation of the C13=C14 torsional isomerization of the retinal chromophore on the excited state potential surface. Here, we present a more detailed discussion of these spectra. The transient hole line shapes are then calculated by solving the density matrix equations for the third-order susceptibility of a multilevel system. The resulting equations are written without reference to the individual vibronic transitions by using the absorption correlation function 〈i‖i(t)〉. The calculations show that the sharp features seen at short delays arise from coherence coupling effects which occur when the pump and probe pulses overlap in time. This analysis demonstrates that the hole seen at 60 fs is consistent with the broad homogeneous absorption line shape for BR568 originally predicted from resonance Raman intensities, and points out the utility of 〈i‖i(t)〉, derived from resonance Raman intensity analysis, in understanding femtosecond dynamic hole-burning experiments.
Cyclopentadienyl−Hydrazido Titanium Complexes:  Synthesis, Structure, Reactivity, and Catalytic Properties (2000)

An η1-hydrazido bis(dimethylamido) complex, [(η5-C5Me4)SiMe2(η1-NNMe2)]Ti(NMe2)2 (2), has been prepared from a neat reaction of (C5Me4H)SiMe2(NHNMe2) (1) with Ti(NMe2)4 at 130 °C via amine elimination. Treatment of 2 with Me3SiCl gives an η2-hydrazido dichloro compound, [(η5-C5Me4)SiMe2(η2-NNMe2)]TiCl2 (3). The reaction of 2 with excess AlMe3 (ca. 5 equiv) affords an AlMe3 adduct, [(η5-C5Me4)SiMe2(η1-NNMe2AlMe3)]TiMe2 (4), which is converted to a dimethyl complex, [(η5-C5Me4)SiMe2(η2-NNMe2)]TiMe2 (5), upon treatment with NEt3. The reaction of 5 with B(C6F5)3 affords a methyl−triarylborate complex, [(η5-C5Me4)SiMe2(NNMe2)]TiMe(μ-Me)B(C6F5)3 (6). The reaction of 2 with H2O produces a tetrameric organotitanoxane [(η5-C5Me4)(SiMe2NHNMe2)Ti]4O6 (7) with an adamantane-like cage structure. However, the reaction of 2 with H2O in the presence of HCl affords a dimeric complex [μ-(OSiMe2-η5-C5Me4)TiCl2]2 (8). Compounds 1−8 have been characterized by spectroscopic and analytical data. Molecular structures of 2, 3, 4, 5, 7, and 8 have been determined by single-crystal X-ray diffraction studies. Complexes 2−5 contain η1-hydrazido (2 and 4) and η2-hydrazido (3 and 5) groups depending on the electronic nature of the titanium center. Reversible interconversion between η1- and η2-hydrazido moieties has been observed upon addition of either NEt3 (4 → 5) or AlMe3 (5 → 4). Complexes 2−5 exhibit moderate catalytic activities for the polymerization of ethene in the presence of either methyaluminoxane (MAO) or AliBu3/Ph3C+B(C6F5)4-.
Rapid preparation of electron beam induced deposition Co magnetic force microscopy tips with 10 nm spatial resolution (2012)

Magnetic force microscope Co spike tips with lateral magnetic resolution of 10 nm have been prepared. The Co spikes are grown by electron beam induced deposition of Co from Co(2)(CO)(8) gas precursor. The high resolution Co spikes are fabricated at the spot of a tightly focused electron beam on the tip of commercial atomic force microscope cantilevers. Qualitative investigations indicate that a spike grown on a planar base of Co improves the signal to noise.
Rhodium(I)-catalyzed hydroboration of olefins. The documentation of regio- and stereochemical control in cyclic and acyclic systems (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRhodium(I)-catalyzed hydroboration of olefins. The documentation of regio- and stereochemical control in cyclic and acyclic systemsDavid A. Evans, Gregory C. Fu, and Amir H. HoveydaCite this: J. Am. Chem. Soc. 1988, 110, 20, 6917–6918Publication Date (Print):September 1, 1988Publication History Published online1 May 2002Published inissue 1 September 1988https://pubs.acs.org/doi/10.1021/ja00228a068https://doi.org/10.1021/ja00228a068research-articleACS PublicationsRequest reuse permissionsArticle Views5991Altmetric-Citations187LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Transient redirection of T cells for adoptive cell therapy with telomerase-specific T helper cell receptors isolated from long term survivors after cancer vaccination (2019)

Adoptive cell therapy (ACT) with retargeted T cells has produced remarkable clinical responses against cancer, but also serious toxicity. Telomerase is overexpressed in most cancers, but also expressed in some normal cells, raising safety concerns. We hypothesize that ACT with T-helper cell receptors may overcome tumour tolerance, mobilize host immune cells and induce epitope spreading, with limited toxicity. From long term survivors after cancer vaccination, we have isolated telomerase-specific T cell receptors (TCRs) from T-helper cells. Herein, we report the development of transient retargeting of T cells with mRNA-based TCRs. This strategy allows for safer clinical testing and meaningful dose escalation. DP4 is the most common HLA molecule. We cloned two telomerase-specific, DP4-restricted TCRs into the mRNA expression vector pCIpA102, together with the sorter/marker/suicide gene RQR8. Donor T cells were electroporated with mRNA encoding TCR_RQR8. The results showed that both TCR_RQR8 constructs were expressed in >90% of T cells. The transfected T cells specifically recognized the relevant peptide, as well as naturally processed epitopes from a 177aa telomerase protein fragment, and remained functional for six days. A polyfunctional and Th1-like cytokine profile was observed. The TCRs were functional in both CD4+and CD8+recipient T cells, even though DP4-restricted. The findings demonstrate that the cloned TCRs confer recipient T cells with the desired telomerase-specificity and functionality. Preclinical experiments may provide limited information on the efficacy and toxicity of T-helper TCRs, as these mobilize the host immune system. We therefore intend to use the mRNA-based TCRs for a first-in-man trial.
Roll isolation bearing design and testing for Low Cost Precision Kill missile system (1998)

This paper addresses the design and evaluation of a bearing joint designed to isolate the guidance electronics section of the Low Cost Precision Kill (LCPK) missile from the motorcase and warhead in the longitudinal roll degree of freedom. Isolation of the guidance section from the motorcase allows the use of readily available, low cost guidance components. The paper will discuss the design requirements for the roll isolation joint, the initial design concept, and subsequent design revisions. The paper concludes with results of simulation runs predicting performance for the second generation roll isolation joint.
Performance Comparison of Current Controllers with Harmonic Compensation for Single-Phase Grid converter (2006)

The current control techniques developed on the basis of the internal model principle (IMP) are well suited for the single-phase photovoltaic systems. The main achievements of these controllers have been: sinusoidal grid current, unity power factor and high immunity to grid harmonic disturbances. Two main families of current controllers have been developed: the first based on the use of resonant controllers and the second based on the use of repetitive controllers. Similarities have been already individuated between these two classes of controllers, however many different implementation possibilities arise (use of selective, full, or any grid voltage feed-forward, implementation via the delta operator or zeta operator, etc.). This paper proposes an exhaustive comparison between these classes of controllers, full of insight judgment, and based on simulation and experimental results.
Evaluation of a polymerase chain reaction-restriction fragment length polymorphism assay for dermatophyte and nondermatophyte identification in onychomycosis (2009)

Improved sensitivity for the detection of fungi in nails was obtained using the PCR-RFLP assay. Rapid and reliable molecular identification of the infectious fungus can be used routinely and presents several important advantages compared with culture in expediting the choice of appropriate antifungal therapy.
Molecular Mechanisms of Collagen Isotype-Specific Modulation of Smooth Muscle Cell Phenotype (2008)

These results show for the first time that collagen IV and collagen I differentially affect smooth muscle phenotypic modulation through multiple pathways.
Chiral Dendrophanes, Dendro[2]rotaxanes, and Dendro[2]catenanes: Synthesis and Chiroptical Phenomena (2000)

New chiral dendrimers with planar-chiral, cycloenantiomeric and topologically chiral cores were prepared in yields of up to 90% starting from a racemic 4-hydroxy[2.2]paracyclophane, a [2]rotaxane with sulfonamide groups in the wheel and axle positions and [2]catenane with a sulfonamide group in both of its macrocycles. The separation of the racemic mixture of these dendrimers was possible by HPLC on chiral stationary phases. The CD spectra of the dendro[2.2]phanes showed a hitherto unknown influence of the dendritic part on the intensities of the Cotton effects. The chirality of these dendrimers is dependent not only on its chiral elements but also on its dendritic wedges and their generation.
Abstract 4091: Evaluating the efficacy of a STING agonist in a murine model of prostate cancer (2019)

Despite the promise of checkpoint inhibitor therapy, prostate cancer has remained resistant to this treatment. Innate immune agonists, however, have been shown to have anti-tumor effects in various cancer types, such as melanoma and colon cancer, and have been nominated to be used in combination with approved anti-PD1/PD-L1 drugs. For instance, STING agonist + anti-PD-1 combination therapy has been demonstrated in a syngeneic mouse model of melanoma. Other innate immune agonists, such as TLR7/8 and TLR9 have also been shown to have potential anti-tumor effects. We hypothesized that innate immune agonists may be effective in the MycCaP syngeneic mouse model of prostate cancer. To compare the efficacy of three innate agonists targeting the STING (3’3’ cGAMP), TLR7/8 (CL097), and TLR9 (ODN2395) pathways, FVB mice were first injected bilaterally with MycCaP subcutaneous tumors. Upon establishment of tumors, mice were administered 3 doses of a single-sided intratumoral injection of each drug. The injected tumors had responses of 50% (6/12), 23% (3/13), and 8% (1/13) for the STING, TLR7/8 and, TLR8 agonists, respectively. Contralateral tumors showed no significant regression.Published data have reported inherent resistance of MycCaP tumors to anti-PD-1 treatment in vivo. Given our results, we hypothesize that the addition of a STING agonist could enhance efficacy of anti-PD-1 therapy in this model. Mice with MycCaP tumors were administered anti-PD1 alone (n=10) or in combination with bilateral injections of the STING agonist (n=14). Combined therapy resulted in significant reduction in tumor size (71%) compared to anti-PD1 alone (9%). Additionally, there was a significant increase in the Ifnb1 (p=.04), Ifng (p=.008), Tnf-α (p=.006), IRF3 (p=.003) and II6 (p<.0001) gene expression in the combination group showing enhancement of the STING pathway genes. Combined, these findings suggest that targeting the STING pathway may have a modest local anti-tumor effect when compared to other innate immune pathways in prostate cancer. The efficacy of anti-PD-1 therapy was significantly enhanced when combined with a STING agonist, possibly through enhancement STING pathway genes. Our data suggest that combination therapy with a STING agonist and anti-PD1 therapy may have potential anti-tumor efficacy in prostate cancer. Future studies will examine these effects on both local and abscopal tumors.Citation Format: Jonathan Gurkan, Jae Eun Choi, Jean Tien, Marcin Cieślik, Luigi Franchi, Arul M. Chinnaiyan. Evaluating the efficacy of a STING agonist in a murine model of prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4091.
A detailed router for field-programmable gate arrays (2002)

The course graph expansion (CGE) detailed routing algorithm is presented for FPGAs (field-programmable gate arrays). The algorithm has the ability to resolve routing conflicts by considering the side-effects of one connection on another, and can be used over a wide range of FPGA interconnection architectures. CGE has been used to obtain excellent routing results for several industrial circuits with various FPGA routing architectures. The results show that CGE is able to route relatively large FPGAs in the absolute minimum number of tracks as determined by global routing, and that CGE has a linear run-time over circuit size.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Optimizing Lateral Lengths in Horizontal Wells for a Heterogeneous Shale Play (2014)

Abstract A successful evaluation and development program in oil- and gas-bearing shales requires considerable analysis and investment, not to mention optimization to help ensure a profitable outcome. Accelerating optimization, reducing capital expenditures, and improving lifecycle net present value (NPV) for the asset are reasonable goals. Seven shale properties are key drivers to help achieve successful play economics. However, the heterogeneity of shales makes well location selection difficult without appraisal well logs and geostatistical mapping of shale property quality. The analysis method allows operators to quickly high-grade areas within a large, heterogeneous shale play using logging suites from a limited number of wellbores in the play. Further, the methodology has been extended to quantify the play's potential reward versus risk distribution for in-fill drilling investments. This study extends the method to optimizing lateral lengths of horizontal wells. Geostatistics provides a means to determine correlation lengths of aggregate shale properties known to be critical to successful economics. The correlation length is used to determine the appropriate length of the horizontal well lateral, restricting it within the highest rock quality for stimulation effectiveness and production rates. Because optimal lateral lengths can be predicted using this approach, it is now possible to pinpoint the best wellhead location, the best landing point for the horizontal portion of the well, and set the optimal length of the lateral. This reduces the drilling of unproductive lateral lengths and targets stimulations. By shortening the "trial-and-error" evaluation lifecycle stage using this methodology, an operator can develop an asset more quickly and at less cost than with previous approaches.