gebhart/patrepeval huggingface dataset:
Steric and conformational effects on the kinetics of ligand substitution in bis(salicylaldiminato)nickel(II) complexes (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSteric and conformational effects on the kinetics of ligand substitution in bis(salicylaldiminato)nickel(II) complexesManfred Schumann, Angela Von Holtum, Klaus J. Wannowius, and Horst EliasCite this: Inorg. Chem. 1982, 21, 2, 606–612Publication Date (Print):February 1, 1982Publication History Published online1 May 2002Published inissue 1 February 1982https://pubs.acs.org/doi/10.1021/ic00132a028https://doi.org/10.1021/ic00132a028research-articleACS PublicationsRequest reuse permissionsArticle Views177Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Antimicrobial Activities of Phytochemicals from British Columbian Medicinal Plants (2018)

Many of the endemic species have never been subjected to phytochemical or pharmacological studies although they have and continue to be used as medicines by First Nations or aboriginal peoples. The Apiaceae is well-known for its phototoxic furano-coumarins and novel antibiotic compounds may be responsible for some degree of the anti-mycobacterial activity observed in these family members. The methanolic plant extracts were screened against 11 bacterial strains. Eighty-nine per cent were found to have significant antibiotic activity. Methanolic extracts showed good antibacterial and antifungal activity. The Haida people of British Columbia used the roots of perennial herb to treat bladder infections and other ailments. The methanolic plant extracts were screened against nine fungal species. Eighty-one were found to have antifungal activity and 30 extracts showed activity against four or more of the fungi assayed. The extract of Geum triflorum and an extract of Epilobium angustifolium completely eliminated activity in the elastase assay.
Predictors of influenza a molecular viral shedding in Hutterite communities (2017)

Patterns of molecular viral shedding vary by age, sex, comorbidity, and the presence of symptoms. Predictor variables vary by influenza A subtype.
Effective refractive error coverage in adults aged 50 years and older: estimates from population-based surveys in 61 countries (2022)

WHO, Sightsavers, The Fred Hollows Foundation, Fondation Thea, Brien Holden Vision Institute, Lions Clubs International Foundation.
Nature of quasi-LO phonon in ZnO (2008)

The quasi-LO phonon mode is related to the specific defects that strongly affect the photonic properties of materials such as zinc oxide (ZnO). The line shapes of the quasi-LO phonon of ZnO annealed in different environments have been investigated. The experimental results show that this mode has the greatest Raman shift to lower wavenumber for the ZnO annealed in ambient atmosphere, suggesting that it has the largest concentration of defects that may be related to its green emission.
Parameters or Privacy: A Provable Tradeoff Between Overparameterization and Membership Inference (2022)

A surprising phenomenon in modern machine learning is the ability of a highly overparameterized model to generalize well (small error on the test data) even when it is trained to memorize the training data (zero error on the training data). This has led to an arms race towards increasingly overparameterized models (c.f., deep learning). In this paper, we study an underexplored hidden cost of overparameterization: the fact that overparameterized models may be more vulnerable to privacy attacks, in particular the membership inference attack that predicts the (potentially sensitive) examples used to train a model. We significantly extend the relatively few empirical results on this problem by theoretically proving for an overparameterized linear regression model in the Gaussian data setting that membership inference vulnerability increases with the number of parameters. Moreover, a range of empirical studies indicates that more complex, nonlinear models exhibit the same behavior. Finally, we extend our analysis towards ridge-regularized linear regression and show in the Gaussian data setting that increased regularization also increases membership inference vulnerability in the overparameterized regime.
Multi-core Scalable Real-time Flash Storage Simulation (2017)

플래시 저장 장치가 저장 장치로서 널리 사용되면서 성능, 신뢰성, 견고성 등 여러 가지 측면에서 검증이 필요하여 시뮬레이션 방법론이 다양하게 연구되어 왔다. 그 결과 최근까지 플래시 저장장치 시뮬레이터는 기능적 모델링과 시간적 모델링 관점에서 많은 발전이 있었다. 그러나 이러한 발전에도 불구하고 플래시 저장장치의 노화 효과를 평가하기 위해서는 장시간의 테스트 시간을 대폭 단축할 수 있는 방법이 필요하다. 본 논문은 사용자 설정에 따라 시뮬레이션 속도를 자유롭게 조절할 수 있는, 소위 멀티 코어 확장성을 제공하는 실시간 시뮬레이션 방법을 제안한다. 제안하는 방법은 임의의 CPU 코어 개수가 주어져도 그에 맞는 확장 가능한 시뮬레이션 속도를 제공하며, 그 속도에 관계없이 항상 정확한 시뮬레이션 결과를 보장한다. 본 논문은 리눅스 커널 모듈 형태로 구현한 시뮬레이터를 이용하여 멀티코어 확장성과 모델의 정확성을 실험적으로 검증한다.
Supplementary Tables from A Digital RNA Signature of Circulating Tumor Cells Predicting Early Therapeutic Response in Localized and Metastatic Breast Cancer (2023)

&lt;p&gt;All supplementary tables&lt;/p&gt;
The Future of Air Conditioning for Buildings - Executive Summary (2016)

Page Not Found - If you're seeing this page, it's because the URL you requested cannot be located. It might not exist or maybe you mistyped it into your browser. But, if you think it's our mistake, please let us know. Otherwise, you have a few options: try using our navigation bar at the top of this page, visit our home page, or browse our products below. - Homepage Basic Content,
Integrated Magneto–Electrochemical Sensor for Exosome Analysis (2016)

Extracellular vesicles, including exosomes, are nanoscale membrane particles that carry molecular information on parental cells. They are being pursued as biomarkers of cancers that are difficult to detect or serially follow. Here we present a compact sensor technology for rapid, on-site exosome screening. The sensor is based on an integrated magneto-electrochemical assay: exosomes are immunomagnetically captured from patient samples and profiled through electrochemical reaction. By combining magnetic enrichment and enzymatic amplification, the approach enables (i) highly sensitive, cell-specific exosome detection and (ii) sensor miniaturization and scale-up for high-throughput measurements. As a proof-of-concept, we implemented a portable, eight-channel device and applied it to screen extracellular vesicles in plasma samples from ovarian cancer patients. The sensor allowed for the simultaneous profiling of multiple protein markers within an hour, outperforming conventional methods in assay sensitivity and speed.
Significant Improvements over the State of the Art? A Case Study of the MS MARCO Document Ranking Leaderboard (2021)

Leaderboards are a ubiquitous part of modern research in applied machine learning. By design, they sort entries into some linear order, where the top-scoring entry is recognized as the "state of the art" (SOTA). Due to the rapid progress being made today, particularly with neural models, the top entry in a leaderboard is replaced with some regularity. These are touted as improvements in the state of the art. Such pronouncements, however, are almost never qualified with significance testing. In the context of the MS MARCO document ranking leaderboard, we pose a specific question: How do we know if a run is significantly better than the current SOTA? Against the backdrop of recent IR debates on scale types, our study proposes an evaluation framework that explicitly treats certain outcomes as distinct and avoids aggregating them into a single-point metric. Empirical analysis of SOTA runs from the MS MARCO document ranking leaderboard reveals insights about how one run can be "significantly better" than another that are obscured by the current official evaluation metric ([email protected]).
MEMS piezoresistive cantilever for the direct measurement of cardiomyocyte contractile force (2017)

This paper reports on a method to directly measure the contractile forces of cardiomyocytes using MEMS (micro electro mechanical systems)-based force sensors. The fabricated sensor chip consists of piezoresistive cantilevers that can measure contractile forces with high frequency (several tens of kHz) and high sensing resolution (less than 0.1 nN). Moreover, the proposed method does not require a complex observation system or image processing, which are necessary in conventional optical-based methods. This paper describes the design, fabrication, and evaluation of the proposed device and demonstrates the direct measurements of contractile forces of cardiomyocytes using the fabricated device.
Induction motor control based on approximate stator flux (2014)

In this study, a novel sensorless method for the induction motor control is proposed. In this method, magnitude and rotational speed of approximate stator flux vector are controlled. In the proposed approximate stator flux control (ASFC) method, utilisation of the mechanical sensors and current transducers is not required. Therefore implementation cost of ASFC is comparable with that of conventional v / f control method. In ASFC, in linear modulation range, to control rotating field speed and stator flux modulus, desired voltage vector components in line with and perpendicular to the stator flux vector are calculated. Based on these two components, three‐phase voltages are applied to three‐phase inverter using pulse‐width modulation strategy. In addition, in overmodulation range, a switching‐table‐based approach is presented to control the rotating field speed by adjusting the stator flux modulus. The relationship between the stator flux modulus and rotating field speed is derived and it is shown that average switching frequency is calculable and under control. Through simulations and experiments, ASFC method is compared with v / f method in terms of motor behaviour in starting and steady‐state operation. Also, correctness of presented formulas is validated by simulations and experimental results.
Prognostic impact of clinical course-specific mRNA expression profiles in the serum of perioperative patients with esophageal cancer in the ICU: a case control study (2010)

Chronological tracking of postoperative mRNA levels of inflammatory-related genes in esophageal cancer patients may facilitate early institution of pharamacologic therapy, prediction of treatment response, and prognostication during ICU management in the perioperative period.
Enumeration and Immunologic Characterization of Basophils in Normal Bone Marrow and Patients with Myeloproliferative Disorders. (2004)

Abstract Basophils are highly specialized granulocytes that express a unique profile of antigens and increase in myeloproliferative disorders. In chronic myeloid leukemia (CML), basophilia is an independent prognostic variable. So far, however, no reliable immunohistochemical approach for routine-detection and enumeration of bone marrow (bm) basophils has become available. To overcome this disadvantage, we have applied the anti-basophil antibody 2D7 on formalin-fixed, paraffin-embedded sections of normal bm and bm from patients (pts) with chronic myeloid leukemia (CML; chronic phase, n=21; accelerated phase, n=9), other myeloproliferative disorders (idiopathic myelofibrosis [IMF], n=3; polycythemia vera [PV], n=7; essential thrombocythemia [ET], n=7), and normal / reactive bm (n=32). As assessed by serial section-staining of bm specimens, the 2D7 antibody was found to be a basophil-specific immunohistochemical reagent. In serial bm sections, 2D7+ basophils co-expressed histidine decarboxylase, CD15, and CD43, but did not express B- or T-cell restricted antigens corresponding to the phenotype of normal blood basophils. Bm basophils were found to increase in number in pts with CML and other myeloproliferative disorders compared to normal bm (median 2D7+ cells/mm2 bm: normal bm: 7; CML: 46; IMF: 26; PV: 21; ET: 21, p&amp;lt;.05). The highest numbers of bm basophils were recorded in pts with accelerated phase CML (111 2D7+ cells/mm2). Together, we have established a useful immunohistochemical staining procedure for basophil detection in normal bm and pts with myeloid neoplasms. This approach should enable the quantification of basophils in these pts and the monitoring of bm basophil counts during follow up examinations and anti-leukemic therapies.
Data from A Novel Bispecific, Trivalent Antibody Construct for Targeting Pancreatic Carcinoma (2023)

&lt;div&gt;Abstract&lt;p&gt;Preclinical and clinical studies have demonstrated the application of radiolabeled mAb-PAM4 for nuclear imaging and radioimmunotherapy of pancreatic carcinoma. We have now examined the ability of a novel PAM4-based, bispecific monoclonal antibody (mAb) construct, TF10, to pretarget a radiolabeled peptide for improved imaging and therapy. TF10 is a humanized, bispecific mAb, divalent for mAb-PAM4 and monovalent for mAb-679, reactive against the histamine-succinyl-glycine hapten. Biodistribution studies and nuclear imaging of the radiolabeled TF10 and/or TF10-pretargeted hapten-peptide (IMP-288) were conducted in nude mice bearing CaPan1 human pancreatic cancer xenografts. &lt;sup&gt;125&lt;/sup&gt;I-TF10 cleared rapidly from the blood, with levels decreasing to &lt;1% injected dose per gram (ID/g) by 16 hours. Tumor uptake was 3.47 ± 0.66% ID/g at this time point with no accumulation in any normal tissue. To show the utility of the pretargeting approach, &lt;sup&gt;111&lt;/sup&gt;In-IMP-288 was administered 16 hours after TF10. At 3 hours postadministration of radiolabeled peptide, imaging showed intense uptake within the tumors and no evidence of accretion in any normal tissue. No targeting was observed in animals given only the &lt;sup&gt;111&lt;/sup&gt;In-peptide. Tumor uptake of the TF10-pretargeted &lt;sup&gt;111&lt;/sup&gt;In-IMP-288 was 24.3 ± 1.7% ID/g, whereas for &lt;sup&gt;111&lt;/sup&gt;In-IMP-288 alone it was only 0.12 ± 0.002% ID/g at 16 hours. Tumor/blood ratios were significantly greater for the pretargeting group (∼1,000:1 at 3 hours) compared with &lt;sup&gt;111&lt;/sup&gt;In-PAM4-IgG (∼5:1 at 24 hours; &lt;i&gt;P&lt;/i&gt; &lt; 0.0003). Radiation dose estimates suggested that TF10/&lt;sup&gt;90&lt;/sup&gt;Y-peptide pretargeting would provide a greater antitumor effect than &lt;sup&gt;90&lt;/sup&gt;Y-PAM4-IgG. Thus, the results suggest that TF10 pretargeting may provide improved imaging for early detection, diagnosis, and treatment of pancreatic cancer as compared with directly radiolabeled PAM4-IgG. [Cancer Res 2008;68(12):4819–26]&lt;/p&gt;&lt;/div&gt;
ChemInform Abstract: EPOXIDATION OF 3‐(3′‐BUTENYL)‐4‐HYDROXYCOUMARINS AND INTRAMOLECULAR 6‐EXO CYCLIZATION TO 3,4‐DIHYDRO‐2‐HYDROXYMETHYL‐2H,5H‐PYRANO(2,3‐B)(1)BENZOPYRAN‐5‐ONES (1984)

Abstract Die aus (I) darstellbaren Olefine (II) werden oxidativ, über ein labiles Epoxid als Zwischenstufe, regioselektiv zu den Benzopyran‐Derivaten (III) cyclisiert.
Low‐Threshold Lasing from Copper‐Doped CdSe Colloidal Quantum Wells (2021)

Abstract Transition metal doped colloidal nanomaterials (TMDCNMs) have recently attracted attention as promising nano‐emitters due to dopant‐induced properties. However, despite ample investigations on the steady‐state and dynamic spectroscopy of TMDCNMs, experimental understandings of their performance in stimulated emission regimes are still elusive. Here, the optical gain properties of copper‐doped CdSe colloidal quantum wells (CQWs) are systemically studied with a wide range of dopant concentration for the first time. This work demonstrates that the amplified spontaneous emission (ASE) threshold in copper‐doped CQWs is a competing result between the biexciton formation, which is preferred to achieve population inversion, and the hole trapping which stymies the population inversion. An optimum amount of copper dopants enables the lowest ASE threshold of ≈7 µJ cm −2 , about 8‐fold reduction from that in undoped CQWs (≈58 µJ cm −2 ) under sub‐nanosecond pulse excitation. Finally, a copper‐doped CQW film embedded in a vertical cavity surface‐emitting laser (VCSEL) structure yields an ultralow lasing threshold of 4.1 µJ cm −2 . Exploiting optical gain from TMDCNMs may help to further boost the performance of colloidal‐based lasers.
Fatty Acid Binding Protein 4‐deficient Mice are Protected from Oxygen‐induced Retinal Neovascularization (2012)

Fatty acid binding protein 4 (FABP4) is a member of the FABP family, which consists of highly conserved proteins that function as chaperones for free fatty acids. FABP4 plays a critical role in maintenance of glucose and lipid homeostasis as well as in the regulation of inflammation. Initially, FABP4 was thought to be expressed primarily by adipocytes and macrophages. We recently determined that FABP4 is also expressed in certain endothelial cells (ECs) where it plays a pro‐angiogenic role. The goal of this study was to determine whether FABP4 plays a role in oxygen‐induced retinal neovascularization. We induced oxygen‐induced retinopathy (OIR) by exposing pups to 75% oxygen between postnatal (P) days 7 and 12. FABP4 mRNA and protein levels were significantly increased during OIR. Immunostaining revealed that FABP4 was strongly expressed in pathological neovessels but absent in normal retinal vessels. In addition, both the neovascular and avascular areas of FABP4−/− retinas were significantly reduced at P17 compared to WT. The effect of FABP4 deficiency on OIR appears independent from macrophages recruitment. The observations that FABP4‐deficient mice are significantly protected from OIR and that FABP4 expression is restricted to neovascular tufts suggests that FABP4 inhibition may be a potential therapeutic target for proliferative retinopathies. This project is funded by the NEI grant 1R21EY021873‐01.
Direct Production of 7-Aminodeacetyl-cephalosporanic Acid byAcremonium chrysogenumHml78 (1991)

Journal Article Direct Production of 7-Aminodeacetyl-cephalosporanic Acid by Acremonium chrysogenum Hml78 Get access Masao Fukagawa, Masao Fukagawa Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5–2–3, Tokodai, Tsukuba, Ibaraki 300–26, Japan Search for other works by this author on: Oxford Academic Google Scholar Takao Isogai, Takao Isogai Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5–2–3, Tokodai, Tsukuba, Ibaraki 300–26, Japan To whom correspondence should be addressed. Search for other works by this author on: Oxford Academic Google Scholar Ichiro Aramori, Ichiro Aramori Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5–2–3, Tokodai, Tsukuba, Ibaraki 300–26, Japan Search for other works by this author on: Oxford Academic Google Scholar Morita Iwami, Morita Iwami Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5–2–3, Tokodai, Tsukuba, Ibaraki 300–26, Japan Search for other works by this author on: Oxford Academic Google Scholar Hitoshi Kojo, Hitoshi Kojo Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5–2–3, Tokodai, Tsukuba, Ibaraki 300–26, Japan Search for other works by this author on: Oxford Academic Google Scholar Takaharu Ono, Takaharu Ono Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5–2–3, Tokodai, Tsukuba, Ibaraki 300–26, Japan Search for other works by this author on: Oxford Academic Google Scholar Masanobu Kohsaka, Masanobu Kohsaka Research and Development Group, Fujisawa Pharmaceutical Co., Ltd., 2–1–6, Kashima, Yodogawa-ku, Osaka 532, Japan Search for other works by this author on: Oxford Academic Google Scholar Hiroshi Imanaka Hiroshi Imanaka Research and Development Group, Fujisawa Pharmaceutical Co., Ltd., 2–1–6, Kashima, Yodogawa-ku, Osaka 532, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 55, Issue 8, 1 August 1991, Pages 2163–2165, https://doi.org/10.1080/00021369.1991.10870933 Published: 01 August 1991 Article history Received: 04 February 1991 Published: 01 August 1991
Supplementary Figure 4 from Identification and Characterization of MEL-3, a Novel AR Antagonist That Suppresses Prostate Cancer Cell Growth (2023)

&lt;p&gt;PDF file, 58KB, MEL-3 does not induce apoptosis via Caspase-3 activation.&lt;/p&gt;
Studies on MHD flow characteristics and heat transfer of liquid metal two-phase flow cooling systems for magnetically confined fusion reactor (1994)

The first wall and blanket cooling systems using liquid metals such as Li, Li-Pb alloys and K are superior to those using normal fluids such as He or water because of liquid metals` higher heat transfer characteristics, lower operational pressure at high temperature, and simpler system of tritium self-breeding. However, under a magnetic field as high as about 10T in a magnetic confined fusion reactor, the liquid metal single-phase flow cooling system receives very high MHD pressure drop and the enhancement of heat transfer, the authors have proposed advanced cooling systems which employ the following liquid metal two-phase flows: a He-Li two-phase annular-mist flow and low-pressure Li or K boiling flows, because it has been expected that overall electrical conductivity can be reduced in the two-phase mixture and the laminarization may be suppressed by two-phase agitating motions. The He-Li two-phase flow system has an additional merit of preheating the cooling circuit by hot helium flow before lithium charge, and the liquid metal boiling flow system has the merits of its simplicity and high thermal efficiency by constructing topping cycle. The advantages of these liquid metal two-phase flow cooling systems are discussed as well as their disadvantages.
Higher-Order Accurate Residual-Distribution Schemes for Unsteady Euler Equations on Unstructured Grids (2005)

In the last years, residual distribution Fluctuation Splitting (FS) schemes using a compact stencil have been developed and applied successfully to compute steady o ws with shocks. Recently, these methods have been extended to compute unsteady o ws, using explicit as well as implicit integration schemes, achieving second-order accuracy in both space and time. In particular, the authors have proposed a second-order-accurate FS scheme based on a dual-time stepping procedure and a linear reconstruction for the unsteady residual, which enjoys a smaller phase error with respect to current state-of-the-art FS schemes based on the Lax{Wendro approach. In the present paper, such a methodology is improved to obtain third-order-accurate FS schemes for scalar-advection problems and inviscid o ws in two dimensions.
Use of multiple reference sources to increase the effective field of view in lensless Fourier-transform holography (1969)

The field of view of a lensless Fourier-transform holography system is limited by the modulation transfer function (MTF) of the recording film, and in a similar fashion by turbulence between the object and the recording plane. A multiple-reference-source technique that partially overcomes this limitation is presented.