gebhart/patrepeval huggingface dataset:
Table S6 from MicroRNA Array Analysis Finds Elevated Serum miR-1290 Accurately Distinguishes Patients with Low-Stage Pancreatic Cancer from Healthy and Disease Controls (2023)

&lt;p&gt;Table S6 - XLSX file 17K, Supplemental Table S6. Diagnostic performance of microRNAs measured by Taqman real-time PCR assays&lt;/p&gt;
Inhibition of Ras and Related G-Proteins As a Therapeutic Strategy for Blocking Malignant Glioma Growth (1998)

Our studies demonstrated that FTI-277, GGTI-286, and GGTI-298 each yielded significant antiproliferative effects in human malignant glioma cells in vitro at low micromolar concentrations, which have been achievable in vivo without major systemic toxicity. Extended periods of drug treatment produced cytotoxicity in the tumor cells, which correlated with the induction of apoptosis. We conclude that inhibition of Ras and related G-proteins offers a promising approach for blocking glioma proliferation that justifies further investigation in vivo.
Epidural gravity flow technique for labor analgesia (2020)

The primary failure rate of labor and surgical analgesia may be as high as 17%. The misidentification of the epidural space with conventional loss of resistance techniques is likely a major contributor.[1][1] Specificity is increased by identifying electronically transduced variation in epidural
The influence of feedback intensity on longitudinal mode properties and optical noise in index-guided semiconductor lasers (1984)

Theory and experiments on optical feedback effects in index-guided single-mode semiconductor lasers are presented. Evidence is found for the existence of a characteristic parameter <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">C</tex> which indicates the relative strength of the optical feedback. Near the transition ( <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">C \approx 1.0</tex> ) from low to high feedback, the feedback-induced low-frequency intensity noise shows a maximum. At higher feedback hysteresis and instabilities are dominant, whereas the feedback-induced noise is low again.
Multi-segment trunk kinematics during a loaded lifting task for elderly and young subjects (2009)

The trunk is frequently modelled as one fixed segment ignoring possible multi-segmental contributions during manual handling. This study compared segmental trunk motion in a young and older population during a lifting task. Twelve elderly and 19 young subjects repeatedly lifted a 5 kg box from bench to shelf under two stance conditions. Displacement and angular trunk segment kinematics were recorded with an electromagnetic tracker system and then analysed. The elderly subjects displayed significantly increased pelvic and trunk displacement and significantly reduced pelvic and lower thorax (T10-L1) range of motion in both stance conditions. Upper thorax (C7-T10) motion was at times greater than lumbar motion and opposite to the lower segments and was related to the task while the lower segments contributed to both equilibrium and task requirements. Decreased segmental trunk angular kinematics may contribute to increased displacement kinematics and place the elderly at increased risk of injury and falling. The pelvis, lumbar spine, low thorax (T10-L1), upper thorax (C7-10) contributed uniquely and synchronously to trunk (C7-S2) mechanics during a lifting task. Reduced angular kinematics of the pelvis and low thorax contributed to increased displacement kinematics and hence increased the risk of falling in the elderly compared to the young. Investigations of trunk mechanics should include multi-segment analysis.
Transcriptional Activation of the Porcine P450 11A Insulin-like Growth Factor Response Element in MCF-7 Breast Cancer Cells (1996)

Insulin-like growth factor-I (IGF-I) stimulates the growth of MCF-7 breast cancer cells. This study determined the transcriptional activity of an IGF-I-responsive region (IGFRE) of porcine P450 11A (P450scc) after transfection into MCF-7 cells. IGF-I induced transcriptional activity of a porcine P450scc core promoter luciferase construct containing the IGFRE transfected in MCF-7 cells. Electrophoretic mobility shift assay with nuclear protein extract from MCF-7 cells showed two transcription factors binding to the IGFRE. Supershift assay determined that one transcription factor was Sp1. Electrophoretic mobility shift assay and transfection experiments with selected mutations to the IGFRE found that binding of both transcription factors was necessary to confer an IGF-I response. The binding activity of both transcription factors was increased with IGF-I treatment. In conclusion, MCF-7 cells contain Sp1 and another unknown transcription factor, P2, that bind to a known IGFRE (porcine P450scc) and induce reporter gene transcriptional activity with IGF-I treatment. Because Sp1 is a ubiquitous transcription factor, determining the identity of P2 may lead to cell-specific methods to impair breast cancer cell growth as mediated by IGF-I.
Wideband Circularly Polarized 3D Wire Antenna for Wi-MAX Applications (2019)

In this paper, a crooked wire antenna is optimized to be functional in both the WLAN and the Wi-Max bands (2.4-2.48 and 3.3-3.7 GHz). The antenna presents a right-hand circular polarization (RHCP) with a 3 dB axial ratio (AR) bandwidth of 3.28 to 4.11 GHz. For the WLAN band (2.4-2.48 GHz), the polarization was linear. The antenna is fabricated using 3D printing techniques and occupy a total volume of 33.8 mm × 30.4 mm × 37.4 mm. The simulated and measured farfield results show good agreement with a radiation pattern that assures a near hemispherical coverage toward the upper hemisphere and a measured maximum gain value of approximately 6 dB. The radiation pattern of the antenna assures a near hemispherical coverage toward the upper hemisphere.
Apoptosis induced by novel aldehyde calpain inhibitors in human tumor cell lines (2006)

Calpain is a class of Ca(2+)-dependent cysteine proteases and has been suggested to be involved in several important signaling cascades. A series of novel aldehyde calpain inhibitors identified in our laboratory were more potent and specific than commercially available calpain inhibitors, and were used to assess the involvement of calpain in cancer. Our inhibitors demonstrated potent anti-proliferative activity in four cancer cell lines (PC-3, HeLa, Jurkat and Daudi) with IC(50)'s ranging from 2 to >30 microM. A non-cancer cell line (CV-1) was 4-7-fold less sensitive than the cancer cell lines. Apoptotic activity was determined and appeared to be inversely correlated to calpain expression levels in the different cell types. Leukemia cell lines (i.e., Daudi and Jurkat) with undetectable m-calpain were more susceptible to the apoptotic effects in response to calpain inhibition, while apoptosis was not detected in PC-3 prostate cancer cells, which highly express m-calpain. The extent of apoptosis in HeLa cells was moderate under identical conditions. Apoptosis induced by calpain inhibition was accompanied by caspase-3 activation. Furthermore, cell cycle analysis showed that aldehyde calpain inhibitors arrested cells at the G2/M boundary in a concentration-dependent manner. These results indicate that aldehyde calpain inhibitors exhibit their cytotoxic effects via induction of G2/M arrest and apoptosis. Importantly, the compounds failed to exert any inhibitory effects toward 20S proteasome. Collectively, our results suggest that calpain is a novel target for the treatment of a variety of cancer diseases and provide leads for further discovery and development of calpain inhibitors.
New optical three dimensional structure measurement method of cone shape micro bumps used for 3D LSI chip stacking (2013)

3D LSI chip stacking technology has been developed in AIST using cone shape micro bumps fabricated by nanoparticle deposition method. The cone shape bumps are suitable for a thermocompression bump joint process with low temperature and low load force, where the bumps are easy to collapse with loading due to the pointed structure. High yield micro bump joints can be obtained. The three dimensional measurement of the cone shape bumps can be done using laser scanning microscope or scanning electron (ion) beam microscope (SEM, SIM). It takes much long time to get the precise three dimensional measurement data. It is not suitable for a mass production inspection test. The highly efficient measurement technique is required for this purpose. We propose a new optical three dimensional structure measurement technique using optical microscopes with CCD cameras or line sensors. In this technique, the dimensional measurement of bumps is done by image processing with three images captured by three microscopes, where one microscope is for a top view and the other two are for slanting views from two directionals which counter.
Gaze-Based Self-Confidence Estimation on Multiple-Choice Questions and Its Feedback (2020)

Self-confidence - an assurance of one's personal decision and ability - is one of the most important factors in learning. When there is a gap between a learner's confidence and comprehension, the learner loses a chance to review a learning subject correctly. To solve this problem, we propose a system which estimates self-confidence while solving multiple-choice questions by eye tracking and gives feedback about which question should be reviewed carefully. The system was evaluated in our experiment involving 20 participants. We observed that correct answer rates of questions were increased by 14% and 17% by giving feedback about correct answers without confidence and incorrect answers with confidence, respectively.
Protocol for evaluation of tumor-derived exosome-induced cancer cell metastasis in a mouse model (2023)

Exosomes mediate intracellular communication between cancer cells and the local/distant microenvironment, which promotes systemic dissemination of cancer. Here, we present a protocol for tumor-derived exosome isolation and in vivo metastasis evaluation in a mouse model. We describe steps for isolating and characterizing exosomes, establishing a metastatic mouse model, and injecting exosomes into mouse. We then detail hematoxylin and eosin staining and analysis. This protocol can be used to investigate exosome function and identify unexplored metastatic regulators related to exosome biogenesis. For complete details on the use and execution of this protocol, please refer to Lee et al. (2023).<sup>1</sup>.
Environmental, Genetic, and Viral Causes of Cancer (2008)

This chapter contains sections titled: Overview Genetic Basis of Cancer Model Organisms of Human Cancer: Mice and Beyond Summary Recommended Reading
Improving utterance verification using additional confidence measures in isolated speech recognition interfaces (2006)

A major problem with speech recognition interfaces is the detection and correct rejection of words that lie outside of the command vocabulary. Given the limited resources provided to an interface, any method that is used to detect out-of-vocabulary (OOV) words should ideally require minimal computational resources. A new utterance verifier is proposed which detects OOV words efficiently using confidence measures calculated for additional words in the N-best list. This approach can be used with any existing confidence measure. We implement this utterance verifier with three different confidence measures and obtain a 3-16% improvement over their standard implementation.
Toward active-matrix lab-on-a-chip: programmable electrofluidic control enabled by arrayed oxide thin film transistors (2011)

Agile micro- and nano-fluidic control is critical to numerous life science and chemical science synthesis as well as kinetic and thermodynamic studies. To this end, we have demonstrated the use of thin film transistor arrays as an active matrix addressing method to control an electrofluidic array. Because the active matrix method minimizes the number of control lines necessary (m + n lines for the m×n element array), the active matrix addressing method integrated with an electrofluidic platform can be a significant breakthrough for complex electrofluidic arrays (increased size or resolution) with enhanced function, agility and programmability. An amorphous indium gallium zinc oxide (a-IGZO) semiconductor active layer is used because of its high mobility of 1-15 cm(2) V(-1) s(-1), low-temperature processing and transparency for potential spectroscopy and imaging. Several electrofluidic functionalities are demonstrated using a simple 2 × 5 electrode array connected to a 2 × 5 IGZO thin film transistor array with the semiconductor channel width of 50 μm and mobility of 6.3 cm(2) V(-1) s(-1). Additionally, using the TFT device characteristics, active matrix addressing schemes are discussed as the geometry of the electrode array can be tailored to act as a storage capacitor element. Finally, requisite material and device parameters are discussed in context with a VGA scale active matrix addressed electrofluidic platform.
Quantitative Visual Characterization of Contaminant Metals and Their Mobility in Fluid Catalytic Cracking Catalysts (2019)

A new approach for characterization of fluid catalytic cracking (FCC) catalysts is proposed. This approach is based on computational visual analyses of images originating from field emission scanning electron microscopy (FE-SEM) studies coupled with elemental mapping via electron dispersive x-ray spectroscopy (EDX) analyses. The concept of contaminant metal mobility is defined and systematically studied through quantification of interparticle transfer and intraparticle penetration of the most common FCC contaminant metals (nickel, vanadium, iron, and calcium). This novel methodology was employed for practical quantification of intraparticle mobility via the Peripheral Deposition Index (PDI). For analyzing and quantifying interparticle mobility, a new index was developed and coined “Interparticle Mobility Index” or IMI. With the development and practical application of these two indices, this study offers the first standardized methodology for quantification of metals mobility in FCC. This novel systematic approach for analyzing metals mobility allows for improved troubleshooting of refinery-specific case studies and for more effective research and development in contaminant metals passivation in FCC catalysts.
Exercise Your Brain (2016)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTExercise Your BrainCarolyn R. BertozziView Author Information Department of Chemistry, Stanford UniversityE-mail: [email protected]Cite this: ACS Cent. Sci. 2016, 2, 7, 430–431Publication Date (Web):July 27, 2016Publication History Published online27 July 2016Published inissue 27 July 2016https://doi.org/10.1021/acscentsci.6b00194Copyright © 2016 American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoiceArticle Views3435Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (183 KB) Get e-AlertsSUBJECTS:Central nervous system,Labeling,Peptides and proteins,Protein dynamics Get e-Alerts
Study of Serum Haptoglobin and Its Glycoforms in the Diagnosis of Hepatocellular Carcinoma:  A Glycoproteomic Approach (2006)

Increased serum haptoglobin concentration and changes in its glycosylation have been reported in certain cancer types. Information for hepatocellular carcinoma (HCC) has not yet been available. In this study, we aimed to carry out a systematic analysis of serum concentrations of haptoglobin (Hp) and its glycoforms in the patients with HCC and noncancer patients only with chronic liver diseases (CLD) and to examine their clinical values. This study was divided into two major parts, (1) measurement of serum Hp concentration, and investigation of its value in the diagnosis of HCC, and (2) quantitative analysis of Hp glycoforms with alpha-2,6-sialylation and/or alpha-1,6-fucosylation by using lectin affinity purification and 2D gel electrophoresis and investigation of their relationships with tumor stage. The concentrations of serum Hp in HCC patients were significantly higher than those in noncancer patients with CLD. With the use of serum concentrations of Hp and alpha-fetoprotein, a logistic regression (LR) model was developed from the training data set and used to classify the validation cases. At a specificity of 95%, the sensitivity for HCC detection was 79%. Comparing serum concentrations of alpha-2,6-sialylated Hp (S-Hp) and alpha-1,6-fucosylated Hp (F-Hp) between HCC and CLD patients suggests that purification of S-Hp and F-Hp could enrich the glycosylation variants associated with HCC. 2D gel analysis of S-Hp and F-Hp identified a total of 18 glycoforms. A unique pattern of Hp glycoforms comprising both hypersialylated fucosylated and hyposialylated fucosylated species was found in the HCC patients. Serum concentrations of these glycoproteins were significantly higher in the patients with advanced tumors, suggesting their tumor-specific nature. We have shown that serum Hp is a potential biomarker in the diagnosis of HCC. The combined use of Hp and AFP could greatly improve the diagnostic accuracy. A unique pattern of Hp glycoforms with altered sialylation and fucosylation is specific to HCC and associated tumor progression.
Towards a Gene Therapy Clinical Trial for Epidermolysis Bullosa (2006)

Genetic mutations affecting the capacity of basal keratinocytes to adhere firmly to the underneath derma lead to severe, often lethal, blistering disorders of the skin known as Epidermolysis Bullosa (EB). About 400,000-500,000 people worldwide are affected and no definitive treatments have yet been developed. Gene therapy might represent an alternative therapeutic approach for these devastating inherited disorders. In the last 10 years pre-clinical studies have shown that human epidermal stem cells can be stably transduced using integrating vectors allowing long-term genetic correction of the adhesion defects affecting EB keratinocytes both in vitro and in vivo after transplantation onto immunodeficient animals. In addition tremendous progress have been achieved in the clinical applications of cultured keratinocytes (cell therapy) for the regeneration of the epidermis over full thickness wounds or the restoration of damaged corneal surfaces. The combination of (i) optimised culturing conditions not altering the epidermal stemness, (ii) gene transfer vectors able to target epidermal stem cells very efficiently and (iii) surgical procedures allowing the grafting of large skin areas have therefore led our group to submit the first phase I/II gene therapy clinical trial for Junctional Epidermolysis Bullosa.
Non invasive transcostal focusing based on the decomposition of the time reversal operator: in vitro validation (2010)

Thermal ablation induced by high intensity focused ultrasound has produced promising clinical results to treat hepatocarcinoma and other liver tumors. However skin burns have been reported due to the high absorption of ultrasonic energy by the ribs. This study proposes a method to produce an acoustic field focusing on a chosen target while sparing the ribs, using the decomposition of the time‐reversal operator (DORT method). The idea is to apply an excitation weight vector to the transducers array which is orthogonal to the subspace of emissions focusing on the ribs. The ratio of the energies absorbed at the focal point and on the ribs has been enhanced up to 100‐fold as demonstrated by the measured specific absorption rates.
Novel Treatment Approaches for Substance Use Disorders: Therapeutic Use of Psychedelics and the Role of Psychotherapy (2021)

Abstract Purpose of Review The use of psychedelics in a therapeutical setting has been reported for the treatment of various diagnoses in recent years. However, as psychedelic substances are still commonly known for their (illicit) recreational use, it may seem counterintuitive to use psychedelic therapy to treat substance use disorders. This review aims to discuss how psychedelics can promote and intensify psychotherapeutic key processes, in different approaches like psychodynamic and cognitive behavioral therapy, with a spotlight on the treatment of substance use disorders (SUD). Recent Findings There is promising evidence of feasibility, safety, and efficacy of psychedelic therapy in SUD. In the whole process of former and current psychedelic therapy regimes that have shown to be safe and efficacious, various psychotherapeutic elements, both psychodynamic and behavioral as well as other approaches, can be identified, while a substantial part of the assumed mechanism of action, the individual psychedelic experience, cannot be distinctly classified to just one approach. Summary Psychedelic therapy consists of a complex interaction of pharmacological and psychological processes. When administered in well-defined conditions, psychedelics can serve as augmentation of different psychotherapy interventions in the treatment of SUD and other mental disorders, regardless of their theoretical origin.
Comparison of nasopharyngeal and saliva swabs for the detection of RNA SARS-CoV-2 during mass screening (SALICOV study). (2021)

In the context of a second wave of SARS-CoV-2 transmission, the use of saliva sampling has become an issue of real importance. SARS-CoV-2 RNA screening was performed on nasopharyngeal and saliva swabs collected from 501 individuals from residential homes for the elderly. The saliva samples were collected at the same time as the nasopharyngeal samples. Nasopharyngeal samples yielded positive results for 26 individuals, only two of whom also tested positive with saliva swabs. In this context, saliva collected by swabbing the fluid is not an ideal sample.
Improvement of copper oxide–tin oxide sensor for dilute hydrogen sulfide (1994)

The influence of the loading and dispersion of CuO on the H2S-sensing properties of CuO–SnO2 sensors has been investigated. The response rates to H2S depend on various factors such as CuO loading, specific surface area (or size) of SnO2 grains, method of loading the SnO2 grains with CuO and the operating temperature. For the CuO–SnO2 sensor prepared by a chemical fixation method, the response rates to dilute H2S (1–10 ppm) increased with decreasing CuO loading, while the sensitivity to H2S decreased monotonically with decreasing amount of CuO dispersed per unit surface area of SnO2. By optimizing these factors, it was possible to obtain a CuO–SnO2 sensor which responded to H2S above 1 ppm at 160 °C with sufficient sensitivity and fairly good response kinetics.
Small‐organ dynamic imaging system (1980)

Dynamic ultrasonic imaging of superficial body organs adds a new dimension to clinical sonographic examinations in that it enables the real-time evaluation of tissue motion and vascular pulsations. A high-frequency (7.2 MHz) linear-array system has been newly developed that generates simultaneous A- and B-mode displays at 60 frames/sec. The instrument produces real-time scan-converted images in standard television format for direct viewing on television (TV) monitors or clinical recording through videotape equipment. Clinical application of this dynamic imaging system has increased the diagnostic capabilities of ultrasound in ophthalmology, radiology, and pediatrics.