MP40-20 RELATIONSHIP BETWEEN NON-TUMOR PROSTATE VOLUME AND RISK OF POSITIVE SURGICAL MARGIN IN ORGAN CONFINED PROSTATE CANCER (2016)

You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy I1 Apr 2016MP40-20 RELATIONSHIP BETWEEN NON-TUMOR PROSTATE VOLUME AND RISK OF POSITIVE SURGICAL MARGIN IN ORGAN CONFINED PROSTATE CANCER Yong Jin Kang, Won Sik Jang, Jong Kyou Kwon, Cheol Yong Yoon, Joo Yong Lee, Kang Su Cho, Won Sik Ham, In Rae Cho, Young Deuk Choi, Myung Soo Kim, and Won Tae Kim Yong Jin KangYong Jin Kang More articles by this author , Won Sik JangWon Sik Jang More articles by this author , Jong Kyou KwonJong Kyou Kwon More articles by this author , Cheol Yong YoonCheol Yong Yoon More articles by this author , Joo Yong LeeJoo Yong Lee More articles by this author , Kang Su ChoKang Su Cho More articles by this author , Won Sik HamWon Sik Ham More articles by this author , In Rae ChoIn Rae Cho More articles by this author , Young Deuk ChoiYoung Deuk Choi More articles by this author , Myung Soo KimMyung Soo Kim More articles by this author , and Won Tae KimWon Tae Kim More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.166AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES It is not uncommon for the prostate cancer to form multiple satellite foci with main index tumor which has kept uniform method for approximation of tumor volume a difficult task. This has been suggested as one reason behind the controversy over association of tumor volume with biochemical recurrence and treatment failure. We have quantified non-tumor prostate volume to analyze its correlation with occurrence of positive surgical margin which is renown as strong predictor of biochemical recurrence. METHODS Among the 1653 patients at the single center who received robot-assisted radical prostatectomy from 2005 to 2014, 629 who were AJCC clinical stage T2 or below with no evidence of distant or lymph node metastasis and have not received neoadjuvant androgen deprivation therapy has been analyzed retrospectively. Non-tumor prostate volume has been calculated by subtracting the aggregated tumor volume of all foci from the measured prostate volume. RESULTS Median patient age was 65 (IQR 60-70) years with preoperative prostate-specific antigen(PSA) of median 6.5 (IQR 4.7-9.9) ng/mL. 214 (34%) patients were at clinical stage T1 and 415 (66%) were at stage T2. Patients with pathologic Gleason score 7 were 320 (50.9%), while 8 or greater were 74 (11.8%). 207 (43%) patients were found to contain positive surgical margins in their postoperative pathologic report. Total prostate volume was median 30.8 (IQR 24.1-38.35) mL and non-tumor prostate volume was median 28.9 (IQR 22.8-36.9) mL. From the logistic regression for the odds of having positive surgical margin, patients with greater non-tumor prostate volume were at decreased odds (p=0.002 OR 0.977) while patients with higher PSA (p=0.002 OR 1.041), higher Gleason score (p=0.002 OR 1.738) were at increased odds. CONCLUSIONS Results from the current study suggests that non-tumor prostate volume tends to be lower in the prostates when there are no extraprostatic organ involvement. This parameter may serve as an indirect indicator for the distance from the tumor margin and prostate capsule, which may show close association with the occurrence of positive surgical margins. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e559 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Yong Jin Kang More articles by this author Won Sik Jang More articles by this author Jong Kyou Kwon More articles by this author Cheol Yong Yoon More articles by this author Joo Yong Lee More articles by this author Kang Su Cho More articles by this author Won Sik Ham More articles by this author In Rae Cho More articles by this author Young Deuk Choi More articles by this author Myung Soo Kim More articles by this author Won Tae Kim More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...