gebhart/patrepeval huggingface dataset:
Gene-expression profiling of buccal epithelium among non-smoking women exposed to household air pollution from smoky coal (2015)

In China's rural counties of Xuanwei and Fuyuan, lung cancer rates are among the highest in the world. While the elevated disease risk in this population has been linked to the usage of smoky (bituminous) coal as compared to smokeless (anthracite) coal, the underlying molecular changes associated with this exposure remains unclear. To understand the physiologic effects of smoky coal exposure, we analyzed the genome-wide gene-expression profiles in buccal epithelial cells collected from healthy, non-smoking female residents of Xuanwei and Fuyuan who burn smoky (n = 26) and smokeless (n = 9) coal. Gene-expression was profiled via microarrays, and changes associated with coal type were correlated to household levels of fine particulate matter (PM2.5) and polycyclic aromatic hydrocarbons (PAHs). Expression levels of 282 genes were altered with smoky versus smokeless coal exposure (P < 0.005), including the 2-fold increase of proinflammatory IL8 and decrease of proapoptotic CASP3. This signature was more correlated with carcinogenic PAHs (e.g. Benzo[a]pyrene; r = 0.41) than with non-carcinogenic PAHs (e.g. Fluorene; r = 0.08) or PM2.5 (r = 0.05). Genes altered with smoky coal exposure were concordantly enriched with tobacco exposure in previously profiled buccal biopsies of smokers and non-smokers (GSEA, q < 0.05). This is the first study to identify a signature of buccal epithelial gene-expression that is associated with smoky coal exposure, which in part is similar to the molecular response to tobacco smoke, thereby lending biologic plausibility to prior epidemiological studies that have linked this exposure to lung cancer risk.
The Surface Preparation of Adherends for Adhesive Bonding (2021)

No AccessAdhesion and Adhesives TechnologyMar 2021The Surface Preparation of Adherends for Adhesive BondingAlphonsus V. PociusAlphonsus V. Pociushttps://doi.org/10.3139/9781569908501.007SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2021Pages: 181-222Print ISBN: 978-1-56990-855-6eISBN: 978-1-56990-850-1 Copyright & Permissions© 2021 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Estrogen accelerates heart regeneration by promoting the inflammatory response in zebrafish (2021)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Electrochemical and ESR characterization of the redox behavior of bis[tris(trimethylsilyl)methyl]diphosphene, (Me3Si)3CP:PC(SiMe3)3 (TsiP:PTsi) (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrochemical and ESR characterization of the redox behavior of bis[tris(trimethylsilyl)methyl]diphosphene, (Me3Si)3CP:PC(SiMe3)3 (TsiP:PTsi)Marcel. Culcasi, Gerard. Gronchi, Jean. Escudie, Claude. Couret, Louis. Pujol, and Paul. TordoCite this: J. Am. Chem. Soc. 1986, 108, 11, 3130–3132Publication Date (Print):May 1, 1986Publication History Published online1 May 2002Published inissue 1 May 1986https://pubs.acs.org/doi/10.1021/ja00271a067https://doi.org/10.1021/ja00271a067research-articleACS PublicationsRequest reuse permissionsArticle Views177Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Sparsity constraints and dedicated acquisition protocols for improved Digital Subtraction Rotational Angiography (2011)

Digital Subtraction Rotational Angiography (DSRA) allows reconstruction of three-dimensional vascular structures from two spins: the contrast is acquired after injecting vessels with a contrast medium, whereas the mask is acquired in the absence of injection. The vessels are then detected by subtraction of the mask from the contrast. Standard DSRA protocol samples the same set of equiangular-spaced positions for both spins. Due to technical limitations of C-arm systems, streak artifacts degrade the quality of all three reconstructed volumes. Recent developments of compressed sensing have demonstrated that it is possible to recover a signal that is sparse in some basis under limited sampling conditions. In this paper, we propose to improve the reconstruction quality of non-sparse volumes when there exists a sparse combination of these volumes. To this purpose, we develop an extension of iterative filtered backprojection that jointly reconstructs the mask and contrast volumes via '1-minimization of sparse priors. A dedicated protocol based upon interleaving both spins is shown to further benefit from the sparsity assumptions, while using the same total number of measurements. Our approach is evaluated in parallel geometry on simulated phantom data.
Winding Layout Considerations for Variable-Pole Induction Motors in Electric Vehicles (2023)

Winding layout plays a crucial role in enabling variable-pole operation in an induction machine (IM). Several winding design alternatives, which consist of toroidal and distributed single- and double-layer windings, have been shown to increase speed range and improve partial load efficiency in traction applications. These windings have different pole-changing capability, end-winding length, leakage, harmonic content, and inverter requirements. This paper compares these winding alternatives with a generalized variable-pole machine design framework that captures the impact of winding selection on key performance metrics such as losses, volume and torque-speed envelop. This framework shows that the core aspect ratio, defined as ratio of stack length to rotor diameter, selected to minimize losses depends on whether a distributed or toroidal winding is used. When a toroidally-wound IM is designed with a low aspect ratio, it can provide the largest torque-speed envelop with highest efficiency over a wide speed range. An experimental toroidally-wound IM driven by an 18-leg converter is used to validate the design framework. The experimental setup is configured externally to emulate a single-layer winding and to show benefits gained from the extra pole-changing flexibility of a toroidal winding.
The RepA protein of plasmid pSC101 controls Escherichia coli cell division through the SOS response (2001)

Although plasmid copy number varies widely among different plasmid species, normally copy number is maintained within a narrow range for any given plasmid. Such copy number control has been shown to occur by regulation of the rate of plasmid DNA replication. Here we report a novel mechanism by which the pSC101 plasmid also can detect an imbalance between the cellular level of its replication protein, RepA, and plasmid‐borne RepA binding sites to inhibit bacterial DNA replication and delay host cell division when RepA is in relative excess. We show that delayed cell division occurs by RepA‐mediated induction of the SOS response and can be reversed by over‐expression of the host DNA primase, DnaG. The effects of RepA excess are prevented by introducing a surfeit of RepA binding sites. The mechanism reported here may help to limit variation in plasmid copy number and allow repopulation of cells with plasmids when copy number falls – potentially pre‐empting plasmid loss in cultures of dividing cells.
Hydrophobicities in the domains of polyelectrolytes (1977)

Abstract The interactions of integral‐or pendant‐type polycations with sodium‐1‐anilino‐8‐naphthalene sulfonate (ANS) were studied by means of their fluorescent spectra. The emission maxima shift to the lower wavelength and fluorescent intensities increase greatly as a result of such complexations. This result may be attributed to the electrostatic interaction and the specific nonpolar environment around the bound ANS. The hydrophobic property in the domain formed by a polycation chain depends on the increase of methylene groups or the existence of a xylylene group between two adjacent cationic sites on the main chain, the existence of benzyl groups on the side chains, and the increase of their molecular weights. It is shown that the hydrophobicities in the domains of polyelectrolytes also change with their conformational changes, i.e., the more contracted their conformations are, the stronger their hydrophobicities are.
Stem Cell Therapy for Treatment of Stress Urinary Incontinence: The Current Status and Challenges (2016)

Stress urinary incontinence (SUI) is a common urinary system disease that mostly affects women. Current treatments still do not solve the critical problem of urethral sphincter dysfunction. In recent years, there have been major developments in techniques to obtain, culture, and characterize autologous stem cells as well as many studies describing their applications for the treatment of SUI. In this paper, we review recent publications and clinical trials investigating the applications of several stem cell types as potential treatments for SUI and the underlying challenges of such therapy.
An Output Buffer for 3.3-V Applications in a 0.13-$\mu$m 1/2.5-V CMOS Process (2009)

With a 3.3-V interface, such as PCI-X application, high-voltage overstress on the gate oxide is a serious reliability problem in designing I/O circuits by using only 1/2.5-V low-voltage devices in a 0.13-mum CMOS process. Thus, a new output buffer realized with low-voltage (1- and 2.5-V) devices to drive high-voltage signals for 3.3-V applications is proposed in this paper. The proposed output buffer has been fabricated in a 0.13-mum 1/2.5-V 1P8M CMOS process with Cu interconnects. The experimental results have confirmed that the proposed output buffer can be successfully operated at 133 MHz without suffering high-voltage gate-oxide overstress in the 3.3-V interface. In addition, a new level converter that is realized with only 1- and 2.5-V devices that can convert 0/1-V voltage swing to 1/3.3-V voltage swing is also presented in this paper. The experimental results have also confirmed that the proposed level converter can be operated correctly
VipariNama: RNA viral vectors to rapidly elucidate the relationship between gene expression and phenotype (2021)

Abstract Synthetic transcription factors have great promise as tools to help elucidate relationships between gene expression and phenotype by allowing tunable alterations of gene expression without genomic alterations of the loci being studied. However, the years-long timescales, high cost, and technical skill associated with plant transformation have limited their use. In this work, we developed a technology called VipariNama (ViN) in which vectors based on the tobacco rattle virus are used to rapidly deploy Cas9-based synthetic transcription factors and reprogram gene expression in planta. We demonstrate that ViN vectors can implement activation or repression of multiple genes systemically and persistently over several weeks in Nicotiana benthamiana, Arabidopsis (Arabidopsis thaliana), and tomato (Solanum lycopersicum). By exploring strategies including RNA scaffolding, viral vector ensembles, and viral engineering, we describe how the flexibility and efficacy of regulation can be improved. We also show how this transcriptional reprogramming can create predictable changes to metabolic phenotypes, such as gibberellin biosynthesis in N. benthamiana and anthocyanin accumulation in Arabidopsis, as well as developmental phenotypes, such as plant size in N. benthamiana, Arabidopsis, and tomato. These results demonstrate how ViN vector-based reprogramming of different aspects of gibberellin signaling can be used to engineer plant size in a range of plant species in a matter of weeks. In summary, ViN accelerates the timeline for generating phenotypes from over a year to just a few weeks, providing an attractive alternative to transgenesis for synthetic transcription factor-enabled hypothesis testing and crop engineering.
ODE analysis and redesign in blind adaptation (1997)

In blind adaptation the dynamics of an unknown channel (system) is recovered together with the transmitted symbol sequence (input signal). This paper generalizes the author's previous algorithm (1994, 1997), that is not derived by criterion minimization, to include adaptive regressor filtering. The resulting scheme, which adapts a finite-dimensional IIR channel model, is designed to converge only to a well-defined set of parameters when binary symbols are transmitted over the channel. This provides a partial solution to the recently discussed ill-convergence problem in blind adaptation. Some connections to adaptive control theory are noted.
A new design-for-reliability approach to thermal fatigue life prediction of leadless solder joints (1997)

Summary form only given. While a tremendous amount of work has been done in leadless solder joint reliability, the detailed thermal fatigue failure mechanisms and their relations with key parameters, e.g., solder fillet, inner end geometry, and microstructure, have, however, not yet been fully understood. Also life prediction methodologies that account for the physics of failure still remain to be developed. In this paper the failure mechanisms of 2512 LCR solder joints are discussed based on thermal fatigue test results, and reliability models for fatigue crack initiation and propagation and the effect of solder height are elaborated.
The fatty acid imbalance of cystic fibrosis exists at birth independent of feeding in pig and ferret models (2022)

Persons with cystic fibrosis (CF) exhibit a unique alteration of fatty acid composition, marked especially among polyunsaturates by relative deficiency of linoleic acid and excess of Mead acid. Relative deficiency of docosahexaenoic acid is variably found. However, the initial development of these abnormalities is not understood. We examined fatty acid composition in young CF ferrets and pigs, finding abnormalities from the day of birth onward including relative deficiency of linoleic acid in both species. Fatty acid composition abnormalities were present in both liver and serum phospholipids of newborn CF piglets even prior to feeding, including reduced linoleic acid and increased Mead acid. Serum fatty acid composition evolved over the first weeks of life in both non-CF and CF ferrets, though differences between CF and non-CF persisted. Although red blood cell phospholipid fatty acid composition was normal in newborn animals, it became perturbed in juvenile CF ferrets including relative deficiencies of linoleic and docosahexaenoic acids and excess of Mead acid. In summary, fatty acid composition abnormalities in CF pigs and ferrets exist from a young age including at birth independent of feeding and overlap extensively with the abnormalities found in humans with CF. That the abnormalities exist prior to feeding implies that dietary measures alone will not address the mechanisms of imbalance.
Magnesium anthracene: an alternative to magnesium in the high yield synthesis of Grignard reagents (1984)

Benzylic type di-Grignard reagents (2)–(5) and the mono-Grignard reagent (6) have been prepared by treating the appropriate organic chloride, for (2)–(6), or bromide, for (3) and (4), with magnesium anthracene in tetrahydroguran in yields of, repectively, 92–96%, and 60 and 84%.
List decoding of Reed-Muller codes up to the Johnson bound with almost linear complexity (2006)

A new deterministic list decoding algorithm is proposed for general Reed-Muller codes RM(s,m) of length n = 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sup> and distance d = 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m-epsi</sup> . Given n and d, the algorithm performs beyond the bounded distance threshold of d/2 and has a low complexity order of nm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">epsi-1</sup> for any decoding radius T that is less than the Johnson bound
The Ganzfeld as a Canvas for Neurophysiologically Based Artworks (1984)

The author describes the ganzfeld, a neurophysiological phenomenon originally discovered and used by researchers studying human perception. The ganzfeld is a perfectly homogeneous visual field that can be used as a canvas for neurophysiologically based artworks. The author describes the neurophysiological effects produced by a standard ganzfeld as well as the artistic possibilities of introducing specific imagery into the ganzfeld. He concludes that the modified ganzfeld is an early step toward future artforms that will directly manipulate our neural circuitries.
Catheter Ablation for Atrial Arrhythmias in Patients With Cardiac Amyloidosis (2016)

Catheter-based ablation for patients with CA appears to provide important symptomatic relief. However, mortality from the underlying disease remains a significant issue for the amyloid light-chain subtype.
Advances in enantiomeric resolution on monolithic chiral stationary phases in liquid chromatography and electrochromatography (2014)

During the last decade, chiral monolithic stationary phases have been prepared and used for rapid enantioseparations in CEC and HPLC. Various chiral selectors are used to prepare these CSPs. The preparation, properties, and applications of these CSPs are discussed in this paper. Attempts have been made to describe optimization strategies and the chiral recognition mechanisms. A comparison of chiral separations in CEC and HPLC is described. Efforts have also been made to predict the future perspectives and challenges of chiral monolithic stationary phases. The most effective chiral selectors include polysaccharides, cyclodextrins, and macrocyclic glycopeptide antibiotics. These chiral phases produced acceptable analytical enantiomeric separation of a variety of racemates. However, the development of these CSPs for preparative-scale separations is needed.
XUV and Soft X-Ray Radiation from Laser Produced Plasmas as Laboratory Spectroscopic Sources (1984)

Laser produced plasmas have been shown to be excellent sources for applications in the XUV and soft X-ray spectral region. We are using a 550 mj, 25 ns (FWHM) ND:YAG laser operating at a repetition rate of 10 Hz to produce plasmas above rotatable solid targets. The focal spot of the laser beam with a 31 cm lens was measured to be 170 μm (approximately twice the diffraction limit), using a diode array having a 170 μm resolution. Broadband output in the soft X-ray region was studied using a windowless PIN photodiode with an A1 2 0 3 surface covered with a polyethylene filter with transmission between 44 Å and 120 Å. Results are presented for the source’s soft X-ray intensity for several elements as a function of laser energy, focus and driving wavelength, as are preliminary results using the source for high resolution spectroscopy and for soft X-ray lithography.
1-Tb/s (10$\times$107 Gb/s) Electronically Multiplexed Optical Signal Generation and WDM Transmission (2007)

We demonstrate the transmission of electronically multiplexed optical signals at a serial data rate of 107 Gb/s. Ten wavelength channels are modulated to provide 1-Tb/s total data capacity at a spectral efficiency of 0.7 bits/s/Hz (144-GHz channel spacing). A single-chip optical equalizer compensates for the optical modulator bandwidth limitations for all wavelengths simultaneously, and the transmission over nonzero dispersion fiber is achieved in both a straight-line 400-km system and in a 1000-km recirculating loop
Recent developments in computational gene recognition (1998)

We survey recent mathematical and computational work in the field of gene recognition, focusing on the techniques that have been developed to tackle the problem of identifying protein coding regions in genes. We also present a new approach to gene recognition which is based on a variety of tools we have developed.
ChemInform Abstract: Syntheses and Structures of New 2,2′‐Bipyridine Complexes of Niobium, Molybdenum, Tungsten, and Rhenium in High Oxidation States. (1990)

Abstract The bipyridine complexes (IV), (Va), (VII), (VIII), (X), (XII), and (XV) are synthesized according to the scheme.
Expression of a rlf/L-myc minigene inhibits differentiation of embryonic stem cells and embroid body formation. (1994)

Rearrangements of the L-myc proto-oncogene with the cellular gene rlf occur in a subset of human small cell lung carcinoma (SCLC) resulting in the expression of a fusion protein. To investigate whether expression of such a rlf/L-myc fusion protein could contribute to the development of SCLC we constructed a chimeric minigene where the rlf first exon and the L-myc second and third exon are under the control of the rlf promoter thereby recapitulating the events of the rearrangement. Attempts to generate transgenic mice with this minigene showed that mouse embryos containing high copy numbers of the rlf/L-myc minigene fail to develop, suggesting that the expression of a rlf/L-myc fusion protein interferes with early differentiation processes. To investigate the nature of this potential embryonic lethality further, we transfected the rlf/L-myc construct stably into embryonic stem (ES) cells. Transfected ES lines that express the rlf/L-myc construct do not show a higher proliferation rate than the parental ES line but fail to properly develop embroid bodies. In addition, outgrowth and differentiation of cells from embroid bodies was severely impaired in ES cells expressing the rlf/L-myc construct when compared to normal ES cells, again suggesting an interference of rlf/L-myc expression with proper differentiation. Expression of a rlf/L-myc fusion may therefore be of critical importance in tumorigenesis by blocking differentiation and thereby allowing continued proliferation of cells and the acquisition of further mutations leading to a fully malignant tumor.