gebhart/patrepeval huggingface dataset:
Solid‐State Electrode Materials with Ionic‐Liquid Properties for Energy Storage: the Lithium Solid‐State Ionic‐Liquid Concept. (2011)

Abstract Herein, the novel concept of a solid‐state electrode materials with ionic‐liquid (IL) properties is presented. These composite materials are a mixture of electroactive matter, an electronic conductor, a solid‐state ionic conductor and a polymeric binder. The approach of a solid‐state ionic conductor combines the high safety of an IL with the nanoconfinement of such a liquid in a mesoporous silica framework, an ionogel, thus leading to a solid with liquid‐like ionic properties. The same ionic conductor is also used as a solid‐state separator to evaluate the properties of our solid‐state electrode materials in all‐solid‐state batteries. Such a concept of a solid‐state electrode material contributes to addressing the challenge of energy storage, which is one of the major challenges of the 21 st century. The ionogel, along with its processability, allows a single‐step preparation of the assembly of the solid‐state electrode and solid‐electrolyte separator and can be applied without specific adaptation to present, thick electrodes prepared by the widespread tape‐casting technique. The filling of the electrode porosity by an ionogel is shown by elemental mapping using scanning electron microscopy, and is subsequently confirmed by electrochemical measurements. The ionogel approach is successfully applied without specific adaptation to two state‐of‐the‐art, positive electroactive materials developed for future‐generation lithium‐ion batteries, namely LiFePO 4 and LiNi 1/3 Mn 1/3 Co 1/3 O 2 .
Use of Coatings on Hydraulic Steel Structures: Part 2-Supplemental Information (2016)

Purpose: This technical note is the second in a two-part series that contains information about coatings systems and coating conditions that exist within the U.S. Army Corps of Engineers (USACE or Corps) and U.S. Bureau of Reclamation (USBR). This second volume focuses on common coating problems, special topics related to coatings, and specific examples encountered in the field survey.
Inducing Models of Black-Box Storage Arrays (2004)

This paper applies statistical model-induction techniques to the problem of forecasting response times in storage systems. Our work differs from prior research in several ways: we regard storage systems as black boxes; we automatically induce models rather than constructing them from detailed expert knowledge; we use lightweight passive observations, rather than extensive controlled experiments, to collect input data; we forecast individual response times rather than aggregates or averages; and we focus on large and complex enterprise storage arrays that comprise many RAID groups. We evaluate our methods using a lengthy storage trace collected in a real-world environment, and measure the predictive value of information available when requests are issued. This paper makes several contributions. First, we quantify the potential of a class of statistical methods for the challenging problem of automatic performance model induction. Second, we quantify improvements in accuracy that result when the range of information available to our models increases. Finally, we describe a general, low-cost modeling methodology that can be applied to a wide range of storage arrays.
Interaction of maytansinoids with MCF7 cells. (2015)

&lt;p&gt;A. Binding of the maytansinoid &lt;sup&gt;3&lt;/sup&gt;[H]-&lt;i&gt;S&lt;/i&gt;-methyl DM1 to the cells, a representative experiment. Cells were incubated in culture medium with various concentrations of &lt;sup&gt;3&lt;/sup&gt;[H]-&lt;i&gt;S&lt;/i&gt;-methyl DM1 at 37° C for 4 h (equilibrium was reached within 4 h) with (squares) or without (circles) an excess (5 μM) of non-labeled &lt;i&gt;S&lt;/i&gt;-methyl DM1, washed two times with medium, and cell-associated radioactivity was measured on a scintillation counter. The specific binding (triangles) was calculated as the difference between the two values. Cell-associated &lt;sup&gt;3&lt;/sup&gt;[H]-&lt;i&gt;S&lt;/i&gt;-methyl DM1 was fully retained by cells after multiple washes, and thus the equilibrium was not distorted during the washes. B. Scatchard plot of A. C. The relationship between the cytotoxicity (IC&lt;sub&gt;50&lt;/sub&gt;) of a maytansinoid and its apparent affinity (ED&lt;sub&gt;50&lt;/sub&gt;) to cells. The IC&lt;sub&gt;50&lt;/sub&gt; values were determined in clonogenic assays after a 4-h exposure of cells to a maytansinoid. Each point (the mean ± standard error) is the result of three independent experiments. The ED&lt;sub&gt;50&lt;/sub&gt; is a concentration of a maytansinoid that decreased the binding of a trace amount of &lt;sup&gt;3&lt;/sup&gt;[H]-&lt;i&gt;S&lt;/i&gt;-methyl DM1 by 50% in a competition binding assay. D. Structures of the maytansinoids. E. Efflux of &lt;sup&gt;3&lt;/sup&gt;[H]-&lt;i&gt;S&lt;/i&gt;-methyl DM1 from MCF7 cells at 37° C in medium (filled symbols), or in the presence of an excess of non-labeled &lt;i&gt;S&lt;/i&gt;-methyl DM1 (open symbols). Triangles and squares represent two independent experiments.&lt;/p&gt;
The role of the brn-2 gene in human melanoma (1995)

The pattern of octamer sequence-specific DNA binding proteins expressed in human melanoma was examined by Electrophoretic mobility shift assay (EMSA) in nuclear extracts of 7 surgically-isolated tumours, short-term cultures of these tumours and 30 human melanoma cell lines to determine the in vivo and in vitro distribution of the melanocytic-associated N-Oct-3 and N-Oct-5 activities. In the biopsy tissue and cultured 
melanoma cells of two metastases from the cerebellum, two other binding activities (N-Oct-2 and N-Oct-6) in addition to the N-Oct-3, N-Oct-5 and the generally expressed Oct-1 protein were detected; this profile was consistent with that seen in normal human and mouse brain tissue, implying that Oct-factor expression may.be modulated by the surrounding tissue in a brain metastasis. Melanoma tissue removed from lymph nodes and cell lines established from them also showed Oct-1, N-Oct-3, N-Oct-5 and N-Oct-2. N-Oct-2 was distinguished from the comigrating Oct-2A activity by failure to react with Oct-2 A-specific antibody. All of the 7 melanoma tumours, 30 melanoma cell lines and normal melanocytes expressed Oct-1 and N-Oct-3, implicating the latter in a fundamental tissue-specific regulatory role. The distribution of expression of the N-Oct-5 activity suggested an inverse association with the differentiated status of melanoma. N-Oct-3 and N-Oct-5 were detected in a range of tumours of cells of neural crest origin, but not in other cell types of the skin, nor in a range of other tumour cells. In contrast to murine fibroblasts which express only Oct-1, human fibroblast strains also expressed Oct-2 A binding activity, confirmed by reactivity with Oct-2A antibody and presence of Oct-2A mRNA, indicating that Oct-2A has a more general role than as a lymphoid-specific transcription factor. 
cDNAs for human brn-2 were cloned from human melanoma cells by screening a melanoma cDNA library with probes to the class III POU genes brn- 1 and brn-4. Polyclonal antibody raised against one of the cDNA clones expressed as a fusion protein in bacteria, cross-reacted with the N-Oct-3 and N-Oct-5 activities in both melanoma cells and in brain, suggesting that brn-2 encodes both of these activities in both cell types. However additional cross-reactivity with N-Oct-2 in brain made these results unclear. A number of the strategies employed prior to the successful cloning of brn-2 have been described and discussed to provide an overview of the approaches that may be taken to clone a novel transcription factor. 
A number of cell lines from Merkel cell carcinoma (MCC) of the skin had been established.
Patterns for parallel programming on GPUs (2013)

ISBN 978-1-874672-57-9
Diminished humoral and cellular responses to SARS-CoV-2 vaccines in patients with chronic lymphocytic leukemia (2022)

Previous studies have demonstrated low rates of seroconversion to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccines in patients with chronic lymphocytic leukemia (CLL). In this national collaboration of 11 cancer centers in the United States, we aimed to further characterize and understand vaccine-induced immune responses, including T-cell responses, and the impact of CLL therapeutics (#NCT04852822). Eligible patients were enrolled in 2 cohorts (1) at the time of initial vaccination and (2) at the time of booster vaccination. The serologic response rates (anti-S) from 210 patients in the initial vaccination cohort and 117 in the booster vaccination cohort were 56% (95% confidence interval [CI], 50-63) and 68% (95% CI, 60-77), respectively. Compared with patients not on therapy, those receiving B-cell-directed therapy were less likely to seroconvert (odds ratio [OR], 0.27; 95% CI, 0.15-0.49). Persistence of response was observed at 6 months; anti-S titers increased with the administration of booster vaccinations. In the initial vaccination cohort, positive correlations were observed between the quantitative serologic response and CD4 T-cell response for the Wuhan variant and, to a lesser degree, for the Omicron variant (Spearman P = 0.45 Wuhan; P = 0.25 Omicron). In the booster vaccination cohort, positive correlations were observed between serologic responses and CD4 T-cell responses for both variants (P = 0.58 Wuhan; P = 0.57 Omicron) and to a lesser degree for CD8 T-cell responses (P = 0.33 Wuhan; P = 0.22 Omicron). Although no deaths from coronavirus disease 2019 (COVID-19) have been reported after booster vaccinations, patients should use caution as newer variants emerge and escape vaccine-induced immunity. This trial was registered at www.clinicaltrials.gov as #NCT04852822.
(Invited) Understanding the Dynamics of Confined Species in Electrochemical Energy Storage Materials (2020)

Layered structures have played an important role in the development of electrochemical energy storage, for the relative ease of ion motion through two-dimensional diffusion channels, and for the stability of the host structure during battery operation. There have been several recent examples in which the performance of ion conducting materials has been improved through the presence of confined species between the layers, potentially through increasing the stability of the layers or enhancing the diffusion of ions. This may be observed for both electrode and electrolyte materials and is exemplified by the recent alternative to ionic liquid (IL) electrolytes, called conductive “solid-like” electrolytes, or the quasi-solid liquid electrolyte (QSLE). In the QSLE based upon boron nitride, ionic liquid electrolyte is confined within the BN layers. The electrolyte is intended to take the higher conductivity advantage of liquid electrolytes and combine this with the superior mechanical stability of BN based solid electrolytes. This hybrid solid electrolyte is derived from few layer nanoporous BN powders; the powders exhibit high surface area (&gt; 800 m 2 /g) with layers and micropores (&lt; 2 nm) for the infiltration of IL. X-ray diffraction indicates that the broad peak associated with the inter-layer separation shifts to longer d-spacing with absorption and confinement of IL. These infiltrated powders are then pressed to form a mechanically stable electrolyte, with high ionic conductivity. Such electrolytes can show robust stability against dendrite formation during battery cycling, which is a key issue in battery safety. While the properties look promising, there has been little fundamental effort to understand the nature of conduction in these solid-like electrolytes. The dynamics of the IL are expected to play a role in the diffusive motion of Na + /Li + cations dissolved within the hybrid electrolyte. Prior work on confinement of ionic liquids using quasi-elastic neutron scattering (QENS), such as in the pores of a mesoporous carbon, have shown that the dynamics of the IL may not follow expected trends. For example, the translational motion of the IL may increase with confinement, and then slow down as the temperature is increased. Here we will present the effect of confinement on the dynamics of ionic liquid in 11 BN layers using the BASIS spectrometer, and discuss this in relation to other confined electrochemical energy storage systems.
Hotspots of methane formation A response to melting sea ice in nitrate stressed Polar surface water (2011)

The Arctic Ocean is one of the regions in the world where climate change is mostly pronounced. Increased summer melting has been considered to amplify biological production as a consequence of the shift from an ice-covered to an open water Arctic Ocean. However, stronger water stratification during sea ice melting generally limits nutrient availability in near-surface water, which in turn hampers the enhancement of primary production and creates oligotrophic conditions in near-surface water after a spring bloom. Because the Arctic Ocean receives water from the Atlantic and the Pacific Ocean and surface water from both oceans differ in their N: P ratio, different stages of oligotrophy are established in Atlantic and Pacific derived Arctic water respectively. Here we report on hotspots of methane formation in the central Arctic Ocean and in the western Fram Strait, which were detected exclusively in Pacific derived water but not in the adjacent Atlantic derived water. We show that nitrate exhaustion is a primary requirement for methane production in aerobicwater. A second pre-condition in the high latitudes is the phosphate excess, which is utilized as a P source by bacteria. Where phosphate is available as a source of P, methylated compounds like DMSP and its degradation products may serve as the bacterial C source. During a regenerated production, when a combination of these conditions exists, methane may be a metabolic by-product and its production could yield energy even under aerobic conditions ([O2] 400 [U+F06D]M). The metabolic activity (respiration) of unicellular organisms explains the presence of anaerobic conditions in the cellular environment. The limiting conditions for the maintenance of a reduced niche inside a cell within an aerobic environment are discussed in terms of a theoretical Model. Methane production may occur as a rapid response to environmental perturbations during the shift from a phytoplankton bloom to an oligotrophic system and is directly linked to the N, P and C cycles. Thus, feedback effects on cycling pathways of the climatically relevant biogases methane and DMS are likely, with DMSP catabolism in high latitudes possibly contributing to a warming effect on the earth’s climate through increasing production of the greenhouse gas, methane.
Characterization of Two Fc Receptors for Mouse Immunoglobulins on Human Monocytes and Cell Lines (1987)

We have previously reported a polymorphism in the mitogenic effect of murine (m) IgG1 anti-CD3 monoclonal antibodies. This polymorphism was genetically determined and could be attributed to polymorphism of the Fc receptor (FcR) for mIgG1 present on human monocytes. We have now extended these studies by quantitating FcR expression on monocytes and cell lines by a recently developed EA rosette assay, using the erythrocyte-associated pseudoperoxidase activity. The data show that the polymorphism of the monocyte FcR for mIgG1 is based on a quantitative rather than an absolute difference. Furthermore, this FcR is specific for mIgG1 and does not bind mIgG2a or mIgG2b nor, surprisingly, human IgG. The expression of this FcR on cell lines correlates with their accessory function in IgG1 anti-CD3-induced T cell proliferation. mIgG2a can inhibit the rosetting of monocytes with erythrocytes sensitized with human IgG. The FcR detected by this rosette technique can interact with all four human IgG subclasses but not with mIgG1 or mIgG2b. The expression of this type of FcR on human cell lines correlates well with their ability to support mIgG2a anti-CD3-induced mitogenesis. These direct measurements of FcR expression support the concept that human monocytes have two independent FcR with affinity for mouse IgG: one receptor specific for mIgG2a (which also binds human IgG), and a second specific for mIgG1.
Helix Formation in Arrestin Accompanies Recognition of Photoactivated Rhodopsin (2009)

Binding of arrestin to photoactivated phosphorylated rhodopsin terminates the amplification of visual signals in photoreceptor cells. Currently, there is no crystal structure of a rhodopsin-arrestin complex available, although structures of unbound rhodopsin and arrestin have been determined. High-affinity receptor binding is dependent on distinct arrestin sites responsible for recognition of rhodopsin activation and phosphorylation. The loop connecting beta-strands V and VI in rod arrestin has been implicated in the recognition of active rhodopsin. We report the structure of receptor-bound arrestin peptide Arr(67-77) mimicking this loop based on solution NMR data. The peptide binds photoactivated rhodopsin in the unphosphorylated and phosphorylated form with similar affinities and stabilizes the metarhodopsin II photointermediate. A largely alpha-helical conformation of the receptor-bound peptide is observed.
Enantioselective total synthesis of aphidicolin (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnantioselective total synthesis of aphidicolinRobert A. Holton, Robert M. Kennedy, Hyeong Baik Kim, and Marie E. KrafftCite this: J. Am. Chem. Soc. 1987, 109, 5, 1597–1600Publication Date (Print):March 1, 1987Publication History Published online1 May 2002Published inissue 1 March 1987https://doi.org/10.1021/ja00239a066RIGHTS & PERMISSIONSArticle Views773Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (462 KB) Get e-Alerts Get e-Alerts
Measurement of the inelastic proton–proton cross-section at √s=7 TeV with the ATLAS detector (2011)

The dependence of the rate of proton–proton interactions on the centre-of-mass collision&#13;\nenergy, √s, is of fundamental importance for both hadron collider physics and particle astrophysics. The dependence cannot yet be calculated from first principles; therefore, experimental measurements are needed. Here we present the first measurement of the inelastic proton–proton interaction cross-section at a centre-of-mass energy, √s, of 7 TeV using the ATLAS detector at the Large Hadron Collider. Events are selected by requiring hits&#13;\non scintillation counters mounted in the forward region of the detector. An inelastic cross-section of 60.3 ± 2.1 mb is measured for ξ &gt; 5×10 − 6, where ξ is calculated from the invariant mass, MX, of hadrons selected using the largest rapidity gap in the event. For diffractive events, this corresponds to requiring at least one of the dissociation masses to be larger&#13;\nthan 15.7 GeV.
Synthesis and Pharmacological Activity of Metabolites of Vasopressin V1 Receptor Antagonist, OPC-21268 (1996)

The metabolites of I-[I-14-(3-acetylaminopropoxy)benzoyll-4piperid-yl]-3,4-dihydro-2(1H)-quinolinone (OPC-21268, I), vasopressin V, receptor antagonist were synthesized to confirm the proposed structures and to examine their vasopressin V, receptor antagonistic activity.The structures of metabolites (Za -6) were identified by means of comparison with synthetic compounds.The activity of the metabolites was found to be lower than that of 1. A new vasopressin V, receptor antagonist, OPC-21268 (1) (1-[l-[4-(3-acetylaminopropoxy)benzoyl]-4-piperidyll-3,4-dihydro-2(1H)-quinolinone) was synthesized by Ogawa er and is now under clinical trial.This compound is an orally effective, nonpeptide antagonist for the arginine vasopressin (AVP)receptor and turned out to be a selective V, antagonist.Metabolism studies are an integral part of all
Protonic Conduction in Phosphate Glasses (1994)

Protons in some alkaline earth metal‐phosphate glasses are much more mobile than monovalent ions such as Na+ and Ag+ ions under a dc electrical field. The O‐H bonding in those glasses that is weakened by the strong hydrogen bonding with neighboring nonbridging oxygen ions may cause the mobile protons.
Current Utilization of Balloon Dilation versus Endoscopic Techniques in Pediatric Sinus Surgery (2014)

BCD was used in 11.9% of pediatric sinus surgery and had higher average charges with no decrease in OR time compared to procedures that only utilized ESS. Future research is necessary to evaluate whether BCD may lead to improved outcomes and eventually decreased operating room time for pediatric patients with chronic rhinosinusitis.
Software-defined LiFi - RF network for Industry 4.0 applications (2022)

Mobility is a crucial aspect when using optical wireless technology (LiFi) in an Industry 4.0 manufacturing environment. This paper presents initial results with the wireless network concept developed in the SESAM-project combining LiFi and radio frequency (RF) prototypes. In a first stage, the performance of a high-speed LiFi cell providing spatial diversity is evaluated when mobility issues are taken into account. As a second step, we demonstrate mobility in the whole manufacturing hall with a software-defined network solution. This enables a low latency vertical handover between a proprietary RF solution, denoted as EchoRing, and the LiFi cell.
Correction: A 32 kb Critical Region Excluding Y402H in CFH Mediates Risk for Age-Related Macular Degeneration (2018)

[This corrects the article DOI: 10.1371/journal.pone.0025598.].
Low-threshold room-temperature lasing in bottom-up photonic crystal cavities formed by patterned III-V nanopillars (2011)

In this work, we present a method whereby the photonic band gap region and active gain regions are formed simultaneously by selective-area metal-organic chemical vapor deposition. This approach allows us the ability to design device parameters lithographically. By accurate control of position and diameter of the NPs, high-g cavities can be formed entirely with NPs. This particular model cavity supports a non-degenerate hexapole mode with a high overlap between the E-field and the center pillars. Design optimization by finite-difference time-domain simulations yields a cavity Q of-5000.
Development of a Large Animal Model for Investigation of Deep Brain Stimulation for Epilepsy (2011)

These preliminary results suggest that the sheep model may be useful for further investigation of DBS for epilepsy. The demonstration of marked suppression of network excitability with high-frequency stimulation supports a potential therapeutic mechanism for this DBS therapy.