gebhart/patrepeval huggingface dataset:
Fine mechanical impedance control using low-noise Class-G power amplifiers (2013)

A fine mechanical impedance control using low-noise Class-G power amplifiers is realized in this paper. In the case of using typical PWM inverter which is categorized as Class-D amplifier, the force and current noise is caused by the PWM switching operations. As a result, the generated mechanical impedance contains the noise. For that reason, the Class-G power amplifiers is used in this research. The force and current noise is reduced by the Class-G amplifiers so that the fine impedance control is achieved. Furthermore, the power efficiency of the Class-G power amplifier is high, compared with another kind of linear amplifiers. By the experiment and analysis of power spectral densities, the validity of the mechanical impedance control using the Class-G power amplifier is verified.
Effect of Liposome Treatment on Hemorheology and Metabolic Profile of Human Red Blood Cells During Hypothermic Storage (2018)

Liposome treatment seemed to be more beneficial when performed at the beginning of storage up to day 21. DOPC liposome treatment resulted in an improvement in human RBC hemorheology upon storage, with no significant impact on metabolic profile.
LQ12, A Novel PKC Activator, Enhances sAPP Secretion in PC-12 Cells (1999)

Research on cellular and molecular aspects of Alzheimer’s disease over the last two decades has resulted in a significantly improved understanding of this disease. Particular achievements have occurred in the areas of molecular genetics and the biology of amyloid. This research has strengthened the notion that Ab is a central player in the disease process.1-5 Despite the progress and the data accumulated, the understanding of the pathophysiological framework remains incipient. Consequently, rational drug design targeting specific pathophysiological events or chemical entities has seen little or slow progress. Additional difficulties arise from the fact that dynamic processes are difficult to assess in the AD brain as a number of signal transduction mechanisms are altered by postmortem events.6 In addition, AD brain tissue usually becomes available after a long period of the disease, at an advanced pathological state. Therefore, significant effort has been devoted to alternative approaches.6-10 A host of cellular and molecular changes ranging from nucleic acid defects to second messenger alterations have been described in peripheral cells of AD patients.6-8,10,11 Some alterations have also been observed in neuronal animal cells and brain.12-15 Of the many alterations, PKC seems uniquely situated in the cascade of events (normal and pathological) interacting with Ab, calcium homeostasis and ion channel function. Herein we propose a framework as an initial step for drug design targeting PKC
Solid-Phase Synthesis of Levoglucosan Derivatives (1998)

Levoglucosan was decorated with a variety of substituents at various sites while being bound to a solid support.
ER,R,OR. FLOOR, OF PULSE AUfPLITUDE WfODULATION WITH ADAPTIVE SAMPLING IN TINfE-DISPERSIVE FADING CHANNELS (2010)

We-: corisider the error floor of coherently arid differentially del,ec;tecl PAM (pulse amplitude modulation) in time-dispersive I’aclirig channels; PAM includes PSK (phase shift keying) and QAM as special cases. We introduce a new Zak-transform IJ>LWXI method [or computing the error floor. This method cari lx applied to arbitrary modulation forrnats and a very general class of t,ime-dispersive channels. We prove that unfiltered BPSK exhibits no error floor when the sampling phase is chosen adsptively and (for coherent detection) the basis pulse satisfies a symmetry condition. For filtered BPSK there is an error floor, which depends on the filter bandwidth. For higher-order modulations, there is always an error floor; it can be attributed to I-Q crosstalk.
Collagen-induced rapid morphogenesis of human mammary epithelial cells: The role of the α 2 β 1 integrin (1992)

The cell line MTSV1-7, originally derived by immortalizing mammary epithelial cells cultured from human milk was able to form three-dimensional structures in collagen gel. We have now found that these cells, cultured as a monolayer, are able to undergo rapid morphogenesis forming ridges and balls around collagen fibres, when soluble collagen type I is added to the medium. Monoclonal antibodies to the alpha 2 (P1E6) and beta 1- (mAB13) subunits of VLA-2, but not to the alpha 3-subunit (P1B5) of VLA-3, could block this collagen-induced rapid morphogenesis (CIRM). The effect of the antibodies on cell attachment, spreading, and migration on collagen gels was analyzed to identify alpha 2 beta 1 dependent steps which might be involved in CIRM. The results suggest that while other proteins, besides alpha 2 beta 1, are also involved in cell attachment and migration, cell spreading was specifically blocked by antibodies to the VLA-2, but not to the VLA-3 integrin. The results demonstrate that the alpha 2 beta 1 integrin plays a crucial role in the collagen-induced morphogenesis of human mammary epithelial cells and implicate the process of VLA-2-dependent cell spreading as an important step in this morphogenesis.
Abstract 4725: Hematopoietic stem cell niche activation and progenitor mobilization mediate cancer-associated immunosuppression and metastasis (2015)

Abstract Metastatic tumors have been shown to establish microenvironments in distant tissues that are permissive to disseminated tumor cells. Hematopoietic cells are essential components of this microenvironment, yet the events that initiate the hematopoietic response remain unclear. Further, the functional contribution of hematopoietic stem and progenitor cells (HSPCs) to metastatic progression has not been addressed. Here, we utilized two highly metastatic C57bl/6 murine cell lines capable of spontaneous metastasis following orthotopic injection to study how the hematopoietic response is initiated and can function to promote metastatic progression in immune competent tumor-bearing mice. In both the E0771 breast carcinoma model and M3-9-M rhabdomyosarcoma model we found that a primary tumor drove expansion of HSPCs within the bone marrow prior to establishment of metastatic lesions. To detect changes within the bone marrow microenvironment that accounted for the observed HSPC expansion in tumor-bearing mice, we performed qPCR analysis of whole femur lysate from control or pre-metastatic tumor-bearing mice. We found the bone marrow microenvironment of tumor-bearing mice expressed a transcriptional program of hematopoietic niche activation that promoted expansion as well as mobilization of hematopoietic progenitors, including downregulation of the HSPC homing cytokine CXCR4. Consistent with this, we detected elevated HSPCs in the circulation of newly diagnosed cancer patients as well as pre-metastatic tumor-bearing mice. By using a pharmacological antagonist of CXCR4 to mobilize HSPCs as seen in the tumor bearing setting, we demonstrated that circulating HSPCs were functionally capable of significantly enhancing metastasis in mice. To determine the mechanisms by which circulating HSPCs can promote metastatic progression, we tracked the developmental fate of flow cytometry-sorted HSPCs injected into the circulation of control or tumor-bearing pre-metastatic mice. We found that HSPCs localized within pre-metastatic tissues preferentially differentiated into the myeloid lineage. Further, depletion of these myeloid cells abrogated the metastasis-promoting effects of HSPC mobilization. Together, these data establish bone marrow niche activation as one of the earliest steps of the metastatic process and identify circulating HSPCs as a potential indicator of metastatic niche initiation. Citation Format: Amber J. Giles, Meera Murgai, Yorleny Vicioso, Steven Highfill, Miki Kasai, Linda Vahdat, Leonard Wexler, Crystal Mackall, David Lyden, Rosandra Kaplan. Hematopoietic stem cell niche activation and progenitor mobilization mediate cancer-associated immunosuppression and metastasis. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4725. doi:10.1158/1538-7445.AM2015-4725
Augmenting RAID with an SSD for energy relief (2008)

In this paper, we describe a design of a novel architecture for RAID that uses an SSD as a large cache to conserve energy. This approach stems from the fact that short term footprints are small enough to be efficiently managed within an SSD. More specifically, in this study, we consider two simple approaches to reduce the energy consumed in RAID. First, when a read happens in RAID, a copy of the read request is copied to the SSD, so that future requests may be serviced by the SSD. Then, for writes, all writes are buffered in SSDs so that the interval between requests may be increased reducing activities at RAID disks. We incorporate these approaches into a real implementation of a RAID 5 system that consists of four hard disks and an SSD in a Linux environment. Our preliminary results in actual performance measurements using the cello99 and SPC traces show that energy consumption is reduced by a maximum of 14%.
Tolerance-band modulation methods for modular multilevel converters (2013)

Modular multilevel converters (M2C) are increasingly used in high voltage direct current (HVDC) systems. The efficiency of M2Cs is highly related to the modulation method which determines the switching frequency and capacitor voltage ripple in the converter station. A new approach to modulation of M2C is presented in this paper. Tolerance-band methods are employed to obtain switching instants, and also cell selection. The proposed methods overcome the modulation problem for converters with few numbers of cells and also reduce the sorting efforts for cell balancing purposes while maintaining the cell-capacitor voltage limits. The evaluation is done by time-domain simulation by which the performance of each method is studied in both steady-state and transient cases. It is observed that using tolerance band methods not only reduces the switching frequency but also allows for handling severe fault cases in a grid connected system. Use of this method can reduce the switching losses and also allow for reduction of the cell capacitor size.
N-(2-Cyanoethoxycarbonyloxy)succinimide:  A New Reagent for Protection of Amino Groups in Oligonucleotides (1999)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTN-(2-Cyanoethoxycarbonyloxy)succinimide: A New Reagent for Protection of Amino Groups in OligonucleotidesMuthiah Manoharan, Thazha P. Prakash, Isabelle Barber-Peoc'h, Balkrishen Bhat, Guillermo Vasquez, Bruce S. Ross, and P. Dan CookView Author Information Department of Medicinal Chemistry, Isis Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, California 92008 Cite this: J. Org. Chem. 1999, 64, 17, 6468–6472Publication Date (Web):July 29, 1999Publication History Received20 November 1998Published online29 July 1999Published inissue 1 August 1999https://pubs.acs.org/doi/10.1021/jo982299yhttps://doi.org/10.1021/jo982299ybrief-reportACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views1188Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Amines,Biopolymers,Genetics,Protective groups,Reagents Get e-Alerts
Empfehlungen für die strukturellen Voraussetzungen der perinatologischen Versorgung in Deutschland (Entwicklungsstufe S2k, AWMF-Leitlinien-Register Nr. 087–001, März 2021) (2021)

vertreten durch Prof. Dr. R. Rossi (Leitlinienkoordinator) und Prof. Dr. S. Kehl
Novel Reconfigurable Isolator (2007)

A novel reconfigurable isolator is presented for future multi-band mobile terminals. The proposed scheme employs a variable matching network (VMN) that uses only a single variable device at the common ground of the isolator. Due to its simple configuration, the circuit size of the reconfigurable isolator is compact. In experiments, the isolator achieves an insertion loss of less than 1.0 dB and a sufficient isolation loss of greater than 15 dB in three frequency bands covering from 1.85 GHz to 2.36 GHz seamlessly. The results show that the proposed isolator with VMN can be extended to multi-band operation for future mobile terminals.
Recombinant Decorin Fusion Protein Attenuates Murine Abdominal Aortic Aneurysm Formation and Rupture (2017)

Decorin (DCN) is a small-leucine rich proteoglycan that mediates collagen fibrillogenesis, organization, and tensile strength. Adventitial DCN is reduced in abdominal aortic aneurysm (AAA) resulting in vessel wall instability thereby predisposing the vessel to rupture. Recombinant DCN fusion protein CAR-DCN was engineered with an extended C-terminus comprised of CAR homing peptide that recognizes inflamed blood vessels and penetrates deep into the vessel wall. In the present study, the role of systemically-administered CAR-DCN in AAA progression and rupture was assessed in a murine model. Apolipoprotein E knockout (ApoE-KO) mice were infused with angiotensin II (AngII) for 28 days to induce AAA formation. CAR-DCN or vehicle was administrated systemically until day 15. Mortality due to AAA rupture was significantly reduced in CAR-DCN-treated mice compared to controls. Although the prevalence of AAA was similar between vehicle and CAR-DCN groups, the severity of AAA in the CAR-DCN group was significantly reduced. Histological analysis revealed that CAR-DCN treatment significantly increased DCN and collagen levels within the aortic wall as compared to vehicle controls. Taken together, these results suggest that CAR-DCN treatment attenuates the formation and rupture of Ang II-induced AAA in mice by reinforcing the aortic wall.
Preface: Gas Turbine Heat Transfer (2011)

Turbine-09 sponsored by the International Center for Heat and Mass Transfer (ICHMT). Turbine-09 was held in Antalya, Turkey, August 9-14, 2009. It was the third symposium related to heat transfer in high-performance gas turbines sponsored by the ICHMT. The first, held in Marathon, Greece, in August 1992, resulted in the book Heat Transfer in Turbomachinery. The second, Turbine 2000, conducted in Cesme, Turkey, in August 2000, was published in the book Heat Transfer in Gas Turbine Systems. The three symposia offered invited keynote lectures and contributed papers by some of the world's best-known authorities on gas turbine heat transfer. Each of the two proceedings volumes and these special issues (Vol. 41, Nos. 6-8, 2010 and Vol. 42, Nos. 1 and 2, 2011) contain a wealth of information from key industrial, academic, and nonprofit laboratories.
DNS-SD Privacy Scaling Tradeoffs (2018)

DNS-SD (DNS Service Discovery) normally discloses information about
both the devices offering services and the devices requesting
services. This information includes host names, network parameters,
and possibly a further description of the corresponding service
instance. Especially when mobile devices engage in DNS Service
Discovery over Multicast DNS at a public hotspot, a serious privacy
problem arises. The draft currently progressing in the DNS-SD Working
Group assumes peer-to-peer pairing between the service to be
discovered and each of its clients. This has good security properties,
but creates scaling issues, because each server needs to publish as
many announcements as it has paired clients. This leads to large
number of operations when servers are paired with many clients.
Different designs are possible. For example, if there was only one
server discovery key known by each authorized client, each server
would only have to announce a single record, and clients would only
have to process one response for each server that is present on the
network. Yet, these designs will present different privacy profiles,
and pose different management challenges. This draft analyses the
tradeoffs between privacy and scaling in a set of different designs,
using either shared secrets or public keys.
Weighted Sum-Rate Maximization for Intelligent Reflecting Surface Enhanced Wireless Networks (2019)

Intelligent reflecting surface (IRS) is a promising solution to build a programmable wireless environment for future communication systems, in which the reflector elements steer the incident signal in fully customizable ways by passive beamforming. This work focuses on the downlink of an IRS-aided multiuser multiple-input single-output (MISO) system. A practical IRS assumption is considered, in which the incident signal can only be shifted with discrete phase levels. Then, the weighted sum-rate of all users is maximized by joint optimizing the active beamforming at the base-station (BS) and the passive beamforming at the IRS. This non-convex problem is firstly decomposed via Lagrangian dual transform, and then the active and passive beamforming can be optimized alternatingly. In addition, an efficient algorithm with closed-form solutions is proposed for the passive beamforming, which is applicable to both the discrete phase- shift IRS and the continuous phaseshift IRS. Simulation results have verified the effectiveness of the proposed algorithm as compared to different benchmark schemes.
Role of Percolation in the Conductance of Electrolyte-GatedSrTiO3 (2012)

We study the electrolyte-gate-induced conductance at the surface of SrTiO(3)(001). We find two distinct transport regimes as a function of gate voltage. At high carrier densities, a percolative metallic state is induced in which, at low temperatures, clear signatures of a Kondo effect are observed. At lower carrier densities, the resistance diverges at low temperatures and can be well described by a 2D variable range hopping model. We postulate that this derives from nonpercolative transport due to inhomogeneous electric fields from imperfectly ordered ions at the electrolyte-oxide interface.
Supplementary Figure 3 from Targeting TRAIL Death Receptor 4 with Trivalent DR4 Atrimer Complexes (2023)

&lt;p&gt;PDF file, 131K,Atrimer� complexes are not cytotoxic to TRAIL-resistant tumor cell lines. Cell viability with candidate DR4 Atrimer� complex treatment for 48 hours in (A) HepG2 and (B) MDA-MB-231 cell lines (n=2).&lt;/p&gt;
Governance of Software Development (2009)

Governance is the exercise of control and direction over a subject such as a society, an organization, processes, or artifacts, by using laws and policies that are defined, deployed, and executed. In this chapter we develop this definition into a formal conceptual model that can be applied to a variety of governance domains. At the heart of this model lies the concept of the governance solution and its lifecycle. The governance solution embodies the set of mechanisms—decision rights, policies, controls, and measurements—applied to a governance scope in order to achieve some governance goals. As part of the lifecycle, the effectiveness of the governance solution is measured, and corrections and alignments are made as necessary. We demonstrate how this model can be applied to multiple governance domains by providing examples from IT governance as well as software-development governance. We conclude by providing a detailed scenario in the software-development governance space, which looks at large software organizations undergoing transition to agile development methodology. We further demonstrate how the governance model is instantiated and evolved in the context of this scenario.
Activation Pattern During His-Bundle Pacing (2021)

Title: Activation Pattern During His-Bundle PacingOmar Yasin MD, MS1, Jamie Bush BS2, Vaibhav Vaidya MBBS1, Jason Tri1, Martin van Zyl, MBBCh1, Peilin Xiao PhD3, Jie Han MD, PhD4, Cory Scheuermann3, Samuel J. Asirvatham, MD1,5, Yong-Mei Cha, M.D1Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USABoston Scientific Corporation, Washington DC, USAThe Second Affiliated Hospital of Chongqing Medical University, Chongqing ChinaThe First Affiliated Hospital of Zhejiang University, Hangzhou, ChinaDepartment of Pediatrics and Adolescent Medicine, Mayo clinic, Rochester, MN, USAFunding: NoneDisclosures: NoneCorresponding AuthorYong-Mei Cha, MD, FHRSDepartment of Cardiovascular Diseases, Mayo Clinic200 1st ST SWRochester, MN 55901Email:ycha@mayo.edu
Targeted Anatomical and Functional Identification of Antinociceptive and Pronociceptive Serotonergic Neurons that Project to the Spinal Dorsal Horn (2022)

Abstract Spinally-projecting serotonergic neurons play a key role in controlling pain sensitivity and can either increase or decrease nociception depending on physiological context. It is currently unknown how serotonergic neurons mediate these opposing effects. Utilizing virus-based strategies, we identified two anatomically separated populations of serotonergic hindbrain neurons located in the lateral paragigantocellularis (LPGi) and the medial hindbrain, which respectively innervate the superficial and deep spinal dorsal horn and have contrasting effects on sensory perception. Our tracing experiments revealed that serotonergic neurons of the LPGi were much more susceptible to transduction with spinally injected AAV2retro vectors than medial hindbrain serotonergic neurons. Taking advantage of this difference, we employed intersectional chemogenetic approaches to demonstrate that activation of the LPGi serotonergic projections decreases thermal sensitivity, whereas activation of medial serotonergic neurons increases sensitivity to mechanical von Frey stimulation. Together these results suggest that there are functionally distinct classes of serotonergic hindbrain neurons that differ in their anatomical location in the hindbrain, their postsynaptic targets in the spinal cord, and their impact on nociceptive sensitivity. The LPGi neurons that give rise to rather global and bilateral projections throughout the rostrocaudal extent of the spinal cord appear to be ideally posed to contribute to widespread systemic pain control.
Legislative Prediction via Random Walks over a Heterogeneous Graph (2012)

In this article, we propose a random walk-based model to predict legislators' votes on a set of bills. In particular, we first convert roll call data, i.e. the recorded votes and the corresponding deliberative bodies, to a heterogeneous graph, where both the legislators and bills are treated as vertices. Three types of weighted edges are then computed accordingly, representing legislators' social and political relations, bills' semantic similarity, and legislator-bill vote relations. Through performing two-stage random walks over this heterogeneous graph, we can estimate legislative votes on past and future bills. We apply this proposed method on real legislative roll call data of the United States Congress and compare to state-of-the-art approaches. The experimental results demonstrate the superior performance and unique prediction power of the proposed model.