gebhart/patrepeval huggingface dataset:
Electron transport and thermoelectric response of Nb- or La-doped SrTiO/sub 3/ epitaxial film at high-temperature (2005)

To clarify the potential of n-type conductive SrTiO/sub 3/ as a high temperature thermoelectric material, carrier concentration dependence of the thermoelectric figure of merit, ZT of SrTiO/sub 3/ at high-temperature (1000 K) is clarified using heavily Nb- or La-doped SrTiO/sub 3/ epitaxial films, which were grown on insulating (100)-oriented LaAlO/sub 3/ single-crystalline substrates by a pulsed-laser deposition method. Carrier concentration, Hall mobility, Seebeck coefficient and thermal conductivity of Nb- or La-doped SrTiO/sub 3/ epitaxial films were experimentally evaluated at 1000 K with an aid of theoretical analysis. The maximum ZT value was obtained ZT = 0.37 for 4 /spl times/ 10/sup 21/ cm/sup -3/ Nb-doped SrTiO/sub 3/ at 1000 K, which is the largest value among n-type oxide semiconductors ever reported.
Efficacious Treatment of Non-Dermatophyte Mould Onychomycosis with Topical Amphotericin B (2011)

Topical amphotericin B is an efficacious, safe, cheap and easy-to-apply treatment which should be considered as first-line therapy for NDM onychomycosis.
ChemInform Abstract: Synthesis of Imidazo[1,5‐a]quinoxalin‐4(5H)‐one Template via a Novel Intramolecular Cyclization Process. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Depolymerization of Poly(ethylene terephthalate) (PET) Using N-Heterocyclic Carbenes from Ionic Liquids (2010)

The depolymerization of the plastic polyethylene terephthalate (PET or PETE) is described in this laboratory procedure. The transesterification reaction used to depolymerize PET employs a highly efficient N-heterocyclic carbene catalyst derived from a commercially available imidazolium ionic liquid. N-heterocyclic carbenes are potent nucleophilic organic catalysts that provide an alternative to traditional metal alkoxide depolymerization catalysts. Deprotonation of the imidazolium generates an N-heterocyclic carbene, which catalyzed the glycolysis of PET in 1 h at atmospheric pressure in refluxing anhydrous tetrahydrofuran to afford bis(2-hydroxyethyl) terephthalate (BHET). BHET is characterized by NMR and IR spectroscopy and melting point determination. This laboratory is designed for individual student work where each student depolymerizes PET prepared from a common water bottle or other source. This experiment is well suited for an introductory organic chemistry laboratory course or a polymer chemistry laboratory course.
Preparation, morphology, and properties of silane‐modified MWCNT/epoxy composites (2009)

Abstract Both epoxy resin and acid‐modified multiwall carbon nanotube (MWCNT) were treated with 3‐isocyanatopropyltriethoxysilane (IPTES). Scanning electron microscopy (SEM) and transmission electronic microscope (TEM) images of the MWCNT/epoxy composites have been investigated. Tensile strength of cured silane‐modified MWCNT (1.0 wt %)/epoxy composites increased 41% comparing to the neat epoxy. Young's modulus of cured silane‐modified MWCNT (0.8 wt %)/epoxy composites increased 52%. Flexural strength of cured silane‐modified MWCNT (1.0 wt %)/epoxy composites increased 145% comparing to neat epoxy. Flexural modulus of cured silane‐modified MWCNT (0.8 wt %)/epoxy composites increased 31%. Surface and volume electrical resistance of MWCNT/epoxy composites were decreased with IPTES‐MWCNT content by 2 orders and 6 orders of magnitude, respectively. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Increasing the Stability of Electroluminescent Phenylenevinylene Polymers by Encapsulation in Nanoporous Inorganic Materials (2004)

Conjugated polyphenylenevinylene oligomer (PPV) encapsulated inside basic zeolites X and Y has been prepared starting from the p-phenylenedimethylene-1,1‘-bis(tetrahydrothiophen-1-ium) monomer introduced through ion exchange followed by heating the intermediate poly[1-(S-tetrahydrothiophenium)-p-phenylenethylene] oligomer at 220 °C under vacuum for 24 h. PPV loading ranged between 1.8 and 5 wt %, the sulfur content of the solid being lower than 0.03 wt %, corresponding to 1 S atom every 400 carbons. The organic oligomer has been characterized by diffuse reflectance UV−vis, IR, and MAS 13C NMR, all the data being in agreement with that reported in the literature for pure PPV and different from those of the tetrahydrothiophenium containing intermediate polymer encapsulated inside zeolites. The solids exhibit the green emission characteristic of PPV. Although the length of the oligomer could not be determined by solid−liquid extraction or by treatment of the zeolite with HF, samples with lower precursor loading showed a 20-nm red-shifted emission with respect to that reported for well-prepared PPV. Thus, it is assumed that the length of the encapsulated oligomer has to be enough to make its properties indistinguishable from those of the nonencapsulated PPV polymer. The zeolite-encapsulated PPV was fairly stable to laser flash photolysis (laser power ∼ 10 mJ pulse-1). The transient spectrum has been mainly attributed to PPV polarons. A cell of a thin film of encapsulated PPV prepared by deep coating shows a current intensity vs voltage response characteristic of a diode and a weak electroluminescence operating at a dc voltage of 2.5 V.
Membrane topology of conserved components of the type III secretion system from the plant pathogen Xanthomonas campestris pv. vesicatoria (2010)

Type III secretion (T3S) systems play key roles in the assembly of flagella and the translocation of bacterial effector proteins into eukaryotic host cells. Eleven proteins which are conserved among gram-negative plant and animal pathogenic bacteria have been proposed to build up the basal structure of the T3S system, which spans both inner and outer bacterial membranes. We studied six conserved proteins, termed Hrc, predicted to reside in the inner membrane of the plant pathogen Xanthomonas campestris pv. vesicatoria. The membrane topology of HrcD, HrcR, HrcS, HrcT, HrcU and HrcV was studied by translational fusions to a dual alkaline phosphatase-beta-galactosidase reporter protein. Two proteins, HrcU and HrcV, were found to have the same membrane topology as the Yersinia homologues YscU and YscV. For HrcR, the membrane topology differed from the model for the homologue from Yersinia, YscR. For our data on three other protein families, exemplified by HrcD, HrcS and HrcT, we derived the first topology models. Our results provide what is believed to be the first complete model of the inner membrane topology of any bacterial T3S system and will aid in elucidating the architecture of T3S systems by ultrastructural analysis.
7.4 Gb/s 6.8 mW Source Synchronous Receiver in 65 nm CMOS (2011)

A high-frequency jitter tolerant receiver in 65 nm CMOS is presented. Jitter tolerance is improved by tracking correlated jitter using a pulsed clock forwarded from the transmitter side. The clock receiver comprises two injection locked oscillators to frequency-multiply, deskew, and adjust jitter tracking bandwidth. Different data rates and latency mismatch between the clock and data paths are accommodated by a jitter tracking bandwidth that is controllable up to 300 MHz. Each receiver consumes 0.92 pJ/bit operating at 7.4 Gb/s and has a jitter tolerance of 1.5 UI at 200 MHz.
Supplemental Figure S2 from A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients (2023)

&lt;p&gt;Supplemental Figure S2. Purified Ovarian Tumor Cells Express EpCam and MUC16/CA125.&lt;/p&gt;
Thermomechanical history effects on rigid PVC microstructure and impact properties (2007)

Abstract Rigid PVC microstructure strongly depends on processing conditions: under both shear and heat influence, gelation process occurs, and the resulting morphology can be characterized by the so‐called gelation level parameter. But thermomechanical history also affects several other features of the microstructure. In this work, two different aspects mainly related to (i) orientation and (ii) molecular mobility are pointed out, and their respective effects on poly(vinyl chloride) (PVC) impact properties are described. Charpy impact tests have been carried out on a typical extruded window profile formulation, evidencing a strong anisotropy effect in those extrudates. It turned out that modulated differential scanning calorimetry was able to evidence macromolecular orientation. Then, the effects of heat treatments on impact properties were investigated. Below the glassy transition temperature ( T g ) of PVC, physical ageing results in a decrease of the impact performance, without affecting PVC anisotropy. The reason of this performance loss is the reduction of the molecular mobility, as evidenced by dynamical mechanical analysis experiments. After performing a heat treatment above T g , another important decrease of the impact performance was observed. This decrease was attributed to (i) partial disorientation of the PVC macromolecular chains and (ii) reduction of the molecular mobility. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 104: 2009–2017, 2007
Uncoupling of RNAi from active translation in mammalian cells (2004)

Small inhibitory RNAs (siRNAs) are produced from longer RNA duplexes by the RNAse III family member Dicer. The siRNAs function as sequence-specific guides for RNA cleavage or translational inhibition. The precise mechanism by which siRNAs direct the RNA-induced silencing complex (RISC) to find the complementary target mRNA remains a mystery. Some biochemical evidence connects RNAi with translation making attractive the hypothesis that RISC is coupled with the translational apparatus for scanning mRNAs. Such coupling would facilitate rapid alignment of the siRNA antisense with the complementary target sequence. To test this hypothesis we took advantage of a well-characterized translational switch afforded by the ferritin IRE-IRP to analyze RNAi mediated cleavage of a target mRNA in the presence and absence of translation. Our results demonstrate that neither active translation nor unidirectional scanning is required for siRNA mediated target degradation. Our findings demonstrate that nontranslated mRNAs are highly susceptible to RNAi, and blocking scanning from both the 5' and 3' ends of an mRNA does not impede RNAi. Interestingly, RNAi is about threefold more active in the absence of translation.
Microoptical phased arrays for spatial and spectral, switching (2003)

This article describes two optical devices based on linear arrays of micromirrors. The first is a phased array of micromirrors that can be rotated as well as translated vertically to maintain coherence across the array. We demonstrate experimentally that such micromirrors are capable of high-diffraction-efficiency phased-array scanning of laser beams. The second device is a Gires-Tournois (1969) interferometer with a micromirror array that provides tunable phase modulation for the multitude of partially reflected beams within the interferometer. We demonstrate experimentally that the MEMS-GT interferometer can operate as a tunable deinterleaver for dense wavelength-division multiplexed fiber optic communication.
Limitations of methods for measuring the concentration of human genomic DNA and oligonucleotide samples (2018)

We compared different methods (absorbance, fluorescent dye-binding, and digital PCR) for measuring the concentrations of human genomic DNA from cultured cells and absorbance measurements of a synthetic DNA oligonucleotide. NIST Standard Reference Material (SRM) 2082, a pathlength absorbance standard, was used to benchmark the absorbance measurements done with microvolume spectrophotometers and a microvolume plate reader. Control absorbance values were measured on a high accuracy spectrophotometer and a NIST calibrated pathlength cuvette. Measurements of the human genomic DNA sample were done with several types of fluorescent dye binding assays using different DNA calibrators. The fluorescent dye binding methods gave different results for genomic DNA depending upon the type of DNA calibrator and the fluorescent dye that was used. The human genomic DNA sample was also characterized by using six different droplet digital PCR assays (amplicons located on different chromosomes) to measure the average copy number. Conversion of the digital PCR data to copy numbers was sensitive to the droplet size used for calculations and conversion to mass concentration was dependent upon the molecular weight of the human genome used for the calculations. The results from the different methods were compared and the caveats for each measurement method were discussed.
Ultrastructural analysis of the pathogenesis of Neisseria gonorrhoeae endometrial infection (2005)

We have studied gonococcal infection in human endometrium organ culture and in human primary endometrial epithelial cells using various microscopic techniques including scanning electron microscopy, transmission electron microscopy, bright field light microscopy and laser scanning confocal microscopy. Here we describe the interactions between Neisseria gonorrhoeae and human endometrial luminal epithelial cells at the ultrastructural levels. N. gonorrhoeae attached to cilia but were not observed associated with the plasma membrane of ciliated epithelial cells or internalized into ciliated epithelial cells. N. gonorrhoeae could be found in intracellular vacuoles in secretory epithelial cells. N. gonorrhoeae have diverse interactions with endometrial epithelium. These include intimate association and colocalization with asialoglycoprotein receptor (ASGP-R) and CEACAM, lamellipodia and ruffle formation and colocalization with CR3, and microvillus engagement. These studies indicate that N. gonorrhoeae utilize multiple mechanisms to associate with endometrial epithelial cells and can associate with both ciliated and secretory cells. This diversity is consistent with a role of the endometrium as a transition zone between frequently asymptomatic cervical gonorrhoea and symptomatic pelvic inflammatory disease.
Phase-conjugate interferometers for testing optical surface (1993)

A new method of detection and characterisation of microdefects on smooth optical surfaces is introduced. The method is based on a spatially resolved histogram analysis of pictures taken with a Differential Interference Contrast microscope (DIC).
Phase-dependent organization of postural adjustments associated with arm movements while walking (1986)

This study examines the interactions between anteroposterior postural responses and the control of walking in human subjects. In the experimental paradigm, subjects walked upon a treadmill, gripping a rigid handle with one hand. Postural responses at different phases of stepping were elicited by rapid arm pulls or pushes against the handle. During arm movements, EMG's recorded the activity of representative arm, ankle, and thigh segment muscles. Strain gauges in the handle measured the force of the arm movement. A Selspot II system measured kinematics of the stepping movements. The duration of support and swing phases were marked by heel and toe switches in the soles of the subjects' shoes. In the first experiment, subjects were instructed to pull on the handle at their own pace. In these trials all subjects preferred to initiate pulls near heel strikes. Next, when instructed to pull as rapidly as possible in response to tone stimuli, reaction times were similar for all phases of the step cycle. Leg muscle responses associated with arm pulls and pushes, referred to as "postural activations," were directionally specific and preceded arm muscle activity. The temporal order and spatial distribution of postural activations in the muscles of the support leg were similar when arm pull movements occurred while the subject was standing in place and after heel strike while walking. Activations began in the ankle and radiated proximally to the thigh and then the arm. Activations of swing leg muscles were also directionally specific and involved flexion and forward or backward thrust of the limb. When arm movements were initiated during transitions from support by one leg to the other, patterns of postural activations were altered. Alterations usually occurred 10-20 ms before hell strikes and involved changes in the timing and sometimes the spatial structure of postural activations. Postural activation patterns are similar during in-place standing and during the support phase of locomotion. Walking and posture control appear to be separately organized but interrelated activities. Our results also suggest that the stepping generators, not peripheral feedback time locked to heel strikes, modulate postural activation patterns.
Thermal quenching of F-center luminescence in Al2O3:C (1998)

Using time-resolved photoluminescence spectroscopy we have measured the lifetime of the F-center luminescence from α-Al2O3:C. The measurements reveal a lifetime of 35–36 ms at room temperature, decreasing to &amp;lt;2 ms over the temperature range from 370 to 500 K. The decrease in the lifetime is shown to follow a classical Mott-Seitz dependence for thermal quenching of luminescence, with an activation energy W of ∼1.08±0.03 eV and a corresponding frequency factor ν of ∼1014 s−1. Similar values for the energy and frequency factor were also obtained from an analysis of thermoluminescence (TL) glow curves measured at different heating rates, when the TL is measured over a wavelength range corresponding to the F-center luminescence emission (centered at 420 nm). Furthermore, the parameters obtained were independent of the glow curve shape, the degree of trap filling, or the specific conditions under which the crystals were grown. This is interpreted as a demonstration that the well-known heating rate dependence of the TL from this material is a result of thermal quenching of the F-center emission. Whereas the thermal quenching parameters obtained from measurement of the luminescence lifetime and from the heating rate analysis of the TL glow curves are independent of the sample type, the degree of trap filling, and the heating or cooling rate, measurements of the photoluminescence intensity, induced by absorption of F-band light, were found to be dependent upon all of the above conditions. This difference in behavior is attributed to a phosphorescence signal from traps associated with the ∼265, ∼310, and ∼450 K TL peaks.
Association of laccase activity with conidiation in an aflatoxigenic strain ofAspergillus parasiticus (1985)

The relationship between laccase activity and asexual development in Aspergillus parasiticus was established. A. parasiticus produced a laccase activity similar to that reported for Aspergillus nidulans. Laccase activity appeared only in conidiating cultures and was absent from vegetative cultures. Shaking of the cultures inhibited conidiation and suppressed laccase activity. The composition of the media affected the degree of conidiation and the specific activity of laccase. Ammonium sulphate as sole nitrogen source was suppressive, whereas glutamate was highly stimulatory to both conidiation and laccase production. The addition of citrate was also stimulatory to conidia production and, to a lesser degree, laccase activity. There appears to be no quantitative correlation between laccase activity and the number of conidia produced.
Prognostic Value and Agreement of Achieving Lactate Clearance or Central Venous Oxygen Saturation Goals During Early Sepsis Resuscitation (2012)

No agreement was found between LC and ScvO(2) goal achievement in early sepsis resuscitation. Achievement of a ScvO(2) ≥ 70% without LC ≥ 10% was more strongly associated with mortality than achievement of LC ≥ 10% with failure to achieve ScvO(2) ≥ 70%.
Comparisons between genetic influence of hypertension and environmental factors on blood pressure level (2003)

We reported that a family history of hypertension (FHHT) has an association with sympathetic overactivity and a resultant BP elevation. Harrap et al reported the same genes and many of the same familial environmental factors determine variation in both SBP and DBP, but BMI shared genetic and environmental determinants to a lesser degree. However, it has not been clarified which has stronger effects on BP levels, of genetic or environmental factors. To evaluate the differences between the influence of genetic hypertension and environmental factors on BP levels and BMI, we measured BMI, BP, plasma norepinephrine (NE), insulin & leptin levels in age- (at entry, 23 yrs), BMI- (nonobese, BMI 21.2 kg/m2), and F/M ratio-matched 3 study group with FHOB- every 1 yr for 5 yrs: 13 spouses (13 F/13 M) with FHHT+, 14 siblings (13 F/17 M) with FHHT+ and 14 spouses (14F/14M) with FHHT-. FHHT+ was defined as at least one parent being hypertensive (≥140/90 mmHg). FHHT- and FHOB- were defined as both parents being normotensive (<130/85 mmHg) or nonobese (BMI<25 kg/m2). At entry, mean BP and NE were similar between spouses with FHHT+ and siblings with FHHT+, but those were significantly less in spouses with FHHT- than in spouses with FHHT+ or siblings with FHHT+ in both gender. BMI, insulin & leptin levels at entry were similar between 3 study groups. At 5 yrs, BMI, mean BP, NE, insulin & leptin levels increased significantly in spouses with FHHT+ and in siblings with FHHT+. The changes in NE and mean BP were noted very early and abrupt (at 1 yr), in contrast to a gradual and lesser increases in BMI, insulin & leptin over 5 yrs in both spouses and siblings groups with FHHT+. In spouses group with FHHT-, mean BP & NE increased slightly, although BMI, insulin & leptin levels did not change over 5 yrs. The increases in BMI, mean BP & NE over 5 yrs were greater in spouses with FHHT+ than in siblings with FHHT+ regardless of gender. In both FHHT+ groups, increases in those parameters were greater in men than women. These results demonstrate that genetic factors of hypertension (shown as FHHT+) have stronger effects on BP elevation, weight gain, and stimulation on sympathetic activity than environmental factors (shown as FHHT-), and that those effects were greater in men than in women. In subjects with FHHT+, sympathetic overactivity appears to play an important role in BP elevation and weight gain.
Polymer excipients enable sustained drug release in low pH from mechanically strong inorganic geopolymers (2012)

Improving acid resistance, while maintaining the excellent mechanical stability is crucial in the development of a sustained and safe oral geopolymer dosage form for highly potent opioids. In the present work, commercially available Methacrylic acid-ethyl acrylate copolymer, Polyethylene-glycol (PEG) and Alginate polymer excipients were included in dissolved or powder form in geopolymer pellets to improve the release properties of Zolpidem, herein acting as a model drug for the highly potent opioid Fentanyl. Scanning electron microscopy, compression strength tests and drug release experiments, in gastric pH 1 and intestinal pH 6.8 conditions, were performed. The polymer excipients, with an exception for PEG, reduced the drug release rate in pH 1 due to their ability to keep the pellets in shape, in combination with the introduction of an insoluble excipient, and thereby maintain a barrier towards drug diffusion and release. Neither geopolymer compression strength nor the release in pH 6.8 was considerably impaired by the incorporation of the polymer excipients. The geopolymer/polymer composites combine high mechanical strength and good release properties under both gastric and intestinal pH conditions, and are therefore promising oral dosage forms for sustained release of highly potent opioids.
Electric field-based ionic control of selective separation layers (2020)

Target ionic control membrane surface multilayers containing target ion channels and target ion exchange sites were created based on ionic control principle and alternating current layer-by-layer assembly technology for extraction of target ions.