gebhart/patrepeval huggingface dataset:
Genistein-induced Growth Inhibition was Associated with Inhibition of Cyclooxygenase-2 and Telomerase Activity in Human Cancer Cells. (2008)

본 연구에서는 대두의 대표적인 생리활성 물질인 genistein의 처리에 따른 암세포의 증식억제에서 telomerase 및 COX-2 활성의 변화 연관성을 조사하였다. 이를 위하여 4가지 종류의 암세포주를 사용하였으며, genistein 처리에 의하여 암세포들의 증식억제에서 백혈병 세포인 U937 세포의 감수성이 감장 높게 나타났으며, genistein 처리에 따라 telomere 조절인자들의 발현이 대부분 억제되었으며, telomerase의 활성도 매우 유의적으로 감소되었다. 또한 genistein처리 농도가 증가함에 따라 COX-2의 발현이 전사 및 번역 수준에서 모두 감소되었으며 이에 따른 <TEX>$PGE_2$</TEX>의 생성 역시 현저하게 감소되었으나, COX-1의 발현에는 큰 변화가 없었다. 이러한 결과들은 genistein의 항암 활성을 이해하는 귀중한 자료로서 활용될 것으로 생각된다. Genistein, an isoflavone in soybean products, is a potential chemopreventive agent against various types of cancer. There are several studies documenting molecular alterations leading to cell cycle arrest at G2/M phase and induction of apoptosis; however, its mechanism of action and its molecular targets on the prostaglandin <TEX>$E_2$</TEX> (<TEX>$PGE_2$</TEX>) production and telomere length regulation in human cancer remain unclear. In this study, we investigated the effect of genistein on the levels of cyclooxygenases (COXs) and telomere regulatory components of several human cancer cell lines (T24, human bladder carcinoma cells; U937, human leukemic cells; AGS, human stomach adenocarcinoma cells and SK-MEL-2, human skin melanoma cells). Genistein treatment resulted in the inhibition of cancer cell proliferation in a concentration-dependent manner. It was found that genistein treatment markedly decreased the levels of COX-2 mRNA and protein expression without significant changes in the expression of COX-1, which was correlated with a decrease in <TEX>$PGE_2$</TEX> synthesis. Genistein treatment also partly inhibited the levels of human telomerase reverse transcriptase (hTERT) as well as human telomerase RNA (hTR) and telomerase-associated protein (TEP)-1, and the activity of telomerase. Taken together, these findings provide important new insights into the possible molecular mechanisms of the anti-cancer activity of genistein.
Vaccines 2020: The era of the digital vaccine is here (2021)

The SARS-CoV-2 pandemic has generated a renaissance in vaccinology, with COVID-19 mRNA vaccines delivering a “digital code” of the viral antigen with no need to purify proteins or inactivate pathogens.
The Role of EGFR in Influenza Pathogenicity: Multiple Network-Based Approaches to Identify a Key Regulator of Non-lethal Infections (2019)

Despite high sequence similarity between pandemic and seasonal influenza viruses, there is extreme variation in host pathogenicity from one viral strain to the next. Identifying the underlying mechanisms of variability in pathogenicity is a critical task for understanding influenza virus infection and effective management of highly pathogenic influenza virus disease. We applied a network-based modeling approach to identify critical functions related to influenza virus pathogenicity using large transcriptomic and proteomic datasets from mice infected with six influenza virus strains or mutants. Our analysis revealed two pathogenicity-related gene expression clusters; these results were corroborated by matching proteomics data. We also identified parallel downstream processes that were altered during influenza pathogenesis. We found that network bottlenecks (nodes that bridge different network regions) were highly enriched in pathogenicity-related genes, while network hubs (highly connected network nodes) were significantly depleted in these genes. We confirmed that this trend persisted in a distinct virus: Severe Acute Respiratory Syndrome Coronavirus (SARS). The role of epidermal growth factor receptor (EGFR) in influenza pathogenesis, one of the bottleneck regulators with corroborating signals across transcript and protein expression data, was tested and validated in additional mouse infection experiments. We demonstrate that EGFR is important during influenza infection, but the role it plays changes for lethal versus non-lethal infections. Our results show that by using association networks, bottleneck genes that lack hub characteristics can be used to predict a gene's involvement in influenza virus pathogenicity. We also demonstrate the utility of employing multiple network approaches for analyzing host response data from viral infections.
Two-Step Growth of (0001) ZnO Single-Crystal Layers on (0001) Sapphire Substrates by Halide Vapor Phase Epitaxy (2011)

The heteroepitaxial growth of (0001) ZnO on (0001) sapphire substrates by halide vapor phase epitaxy using a two-step growth procedure was investigated. X-ray diffraction analysis revealed that single-crystal (0001) ZnO layers on (0001) sapphire substrates were grown at 400 °C. High-temperature heteroepitaxy at 1000 °C on (0001) sapphire substrates was realized by two-step growth using the ZnO layer grown at 400 °C as a buffer layer. Two-dimensional layer growth at 1000 °C was realized on buffer layers thicker than 0.4 µm. Photoluminescence (PL) measurements performed at room temperature for the ZnO layer grown on the 0.4-µm-thick buffer layer showed a significant blueshift of near-band-edge emission (NBE). A thick buffer layer of 0.8 µm was found to be necessary for a successful two-step growth without a blueshift of NBE in the PL spectra, which is caused by a large compressive stress.
Optimization of robotic trajectories for thermal spray shape deposition (2018)

Abstract: "Thermal spray shape deposition is a new process for fabricating net-shape parts by incremental material build-up of cross-sectional layers. This paper presents an approach for spraying thin, flat layers using a robotic spray system. Asymmetries of the spray distribution are first corrected by tilting the spray torch based upon a computer model of the measured spray distribution. The path of the torch is then found using heuristics which are based upon the estimated standard deviation of the corrected distribution. For example, thick arc sprayed coatings (i.e. ╠â4mm) have been deposited using this method with the resulting standard deviation from the mean thickness between 20to 30 [mu]m. To demonstrate the shape deposition process, a layered prototype turbine blade shape was built using these optimized trajectories."
SEAM and EBIC studies of morphological and electrical defects in polycrystalline silicon solar cells (2010)

Morphological and electrical defects in solar cells are distinguished by combining Scanning Electron Acoustic Microscopy (SEAM) and Electron Beam Induced Current (EBIC) techniques. These techniques provide complementary information on grain boundaries and defects that affect solar cell performance in different ways.
Estradiol-inducible AvrRps4 expression reveals distinct properties of TIR-NLR-mediated effector-triggered immunity (2019)

Abstract Plant nucleotide-binding domain, leucine-rich repeat receptor (NLR) proteins play important roles in recognition of pathogen-derived effectors. However, the mechanism by which plant NLRs activate immunity is still largely unknown. The paired Arabidopsis NLRs RRS1-R and RPS4, that confer recognition of bacterial effectors AvrRps4 and PopP2, are well studied, but how the RRS1/RPS4 complex activates early immediate downstream responses upon effector detection is still poorly understood. To study RRS1/RPS4 responses without the influence of cell-surface receptor immune pathways, we generated an Arabidopsis line with inducible expression of effector AvrRps4. Induction does not lead to hypersensitive cell death response (HR) but can induce electrolyte leakage, which often correlates with plant cell death. Activation of RRS1 and RPS4 without pathogens cannot activate mitogen-associated protein kinase cascades, but still activates upregulation of defense genes, and therefore resistance against bacteria. Highlight Inducible expression of AvrRps4 activates RRS1/RPS4-mediated effector-triggered immunity without the presence of pathogens, allowing us to characterise downstream immune responses triggered by TIR-NLRs without cell-surface receptor-mediated immunity.
Supplementary Figure S1 from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP (2023)

&lt;p&gt;Structurally diverse PI3K/mTOR inhibitors induce MYC and YAP up-regulation in resistant MCAS-R cells.&lt;/p&gt;
ENDOVASCULAR CONTRIBUTIONS TO TREATMENT OF TYPE A AORTIC DISSECTION (2008)

Endovascular treatment of the aortic arch has developed slowly because of the complex characteristics intrinsic to arch anatomy. These characteristics include the 270° curvature, variable rotational anatomy and diameter of the supra-aortic trunks, close proximity of the aortic valve and coronary ostia, and wide variability of etiologies that warrant intervention in this aortic segment. These characteristics will impact on design of useful devices, but also on the design of the delivery system, and the conduct, timing and indications of the intervention. Published endovascular series involving arch and ascending aortic pathology has largely involved hybrid procedures that are extraanatomic, or are staged and involve a preliminary invasive step. The published experience of pure endovascular repair for disease involving the arch is limited and experimental. Acute type A dissection is an indication for surgical intervention because of potential for deterioration after valvular involvement, coronary involvement, rupture or death, but the role of endovascular repair in both the acute and chronic setting has been limited by the inadequacy of current thoracic devices. The presence of concurrent descending thoracic or abdominal aortic involvement and the innovation of new devices that accommodate the ascending aorta and arch are 2 scenarios where the endovascular approach can be used and has been reported in type A dissection. It is becoming clear that any approach to the aorta requires a clear vision of potential future needs and a recognition of ‘vulnerable aorta’ that is prone to dilation in the future. This talk will review ascending aortic dissection and explore the evolving role of endovascular intervention in this territory.
A 0.11-mW 2.4-GHz Receiver Employing a Q-Boosted Impedance Transformer and Regenerative Amplifier Achieving −101-dBm Sensitivity and −28-dB SIR (2023)

This letter presents a 2.4-GHz OOK receiver that employs a <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$Q$ </tex-math></inline-formula> -boosted impedance transformer and a regenerative amplifiers (RA) to provide high gain and sharp filtering prior to demodulation. A differential envelope detector (ED) is also used to increase the conversion gain further to help nullify the noise contribution of the subsequent baseband stages. Fabricated in 65 nm, the receiver achieves a sensitivity of −101 dBm at a data rate of 5 Kb/s, all while consuming <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$112~\mu \text{W}$ </tex-math></inline-formula> . The sharp RF filtering helps enable a signal-to-interference ratio (SIR) of −28 dB.
High-pressure electrochemical CO2 reduction (2019)

Electrochemical reduction of CO2 to valuable chemicals has been intensively studied in recent years. Previous studies have been mainly performed under ambient pressure where CO2 solubility is low in the electrolyte, especially in water. This limits the current density to a low range that is not applicable for industrial applications. Applying a high pressure would be a promising way to increase the solubility of CO2 in the electrolyte and thus increase both the current density and the selectivity for CO2 reduction. In this project, we will develop an electrolysis setup where CO2 reduction can be studied under high pressure. The starting point is will be using single metal atom catalysts to catalyze CO2 reduction to CO in aqueous media
Leveraging the Polymer Glass Transition to Access Thermally Switchable Shear Jamming Suspensions (2023)

Suspensions of polymeric nano- and microparticles are fascinating stress-responsive material systems that, depending on their composition, can display a diverse range of flow properties under shear, such as drastic thinning, thickening, and even jamming (reversible solidification driven by shear). However, investigations to date have almost exclusively focused on nonresponsive particles, which do not allow <i>in situ</i> tuning of the flow properties. Polymeric materials possess rich phase transitions that can be directly tuned by their chemical structures, which has enabled researchers to engineer versatile adaptive materials that can respond to targeted external stimuli. Reported herein are suspensions of (readily prepared) micrometer-sized polymeric particles with accessible glass transition temperatures (<i>T</i> <sub>g</sub>) designed to thermally control their non-Newtonian rheology. The underlying mechanical stiffness and interparticle friction between particles change dramatically near <i>T</i> <sub>g</sub>. Capitalizing on these properties, it is shown that, in contrast to conventional systems, a dramatic and nonmonotonic change in shear thickening occurs as the suspensions transition through the particles' <i>T</i> <sub>g</sub>. This straightforward strategy enables the <i>in situ</i> turning on (or off) of the system's ability to shear jam by varying the temperature relative to <i>T</i> <sub>g</sub> and lays the groundwork for other types of stimuli-responsive jamming systems through polymer chemistry.
Sensing of Biomagnetic Activity from Mammalian Tissues Using a Diamond Quantum Sensor (2022)

We report the first magnetic measurements of electrical activity from in vitro mammalian muscle and brain tissue. By using Nitrogen-Vacancy centers in diamond, these measurements can be carried out non-invasively and in an unshielded laboratory.
Qatar Biobank: COVID-19 biorepository project (2021)

Background: The rapid spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its resulting disease (COVID-19) is one of the greatest global public health crisis of the recent decades. The COVID-19 Biorepository is a national project aimed to support the high demand of biomedical research by multiple groups and the need to have access to high quality, curated clinical data, and specimens contributing to the understanding of, and response to, the COVID-19 pandemic and its impacts in Qatar. Methods/Case presentation: Patients with a laboratory diagnosis of COVID-19, who were Qatar residents that could communicate in Arabic, English, Hindi, and Urdu were eligible to participate in the study. COVID-19 diagnosed patients were recruited at the time of their disease period from the main three public hospitals (Communicable Disease Center, Cuban, and Hazm Mebaireek Hospitals) serving as isolation facilities of symptomatic patients in Qatar, during a 7-month period from March 2020 until September 2020. Consented participants were followed up on a weekly basis until recovery, and then monthly for a year. Sociodemographic and clinical data were collected in electronic questionnaires via a face-to-face interview by trained Qatar Biobank (QBB) staff. Results: A total of 2097 consented participants were recruited up to September 2020, males (N = 1050) and females (N = 1047), with a mean age of 41 years (SD: 15.5). 61.0% of the participants had at least one follow up while 27% adhered to monthly follow up visits. Data was collected for 99.7% of the participants, while the follow up process is still ongoing. In total there are 107,171 high quality specimens in the biorepository including plasma, erythrocytes, buffy coat, serum, PAXgene whole blood, nasopharyngeal secretions, and DNA. Conclusion: The COVID-19 Biorepository is a national asset to illuminate the pathophysiological and identify markers of disease prognosis as well as to describe the clinical features and epidemiology of COVID-19 in Qatar and worldwide.
Pterulinic Acid and Pterulone, Two Novel Inhibitors of NADH: Ubiquinone Oxidoreductase (Complex I) Produced by a Pterula Species. I. Production, Isolation and Biological Activities. (1997)

Pterulinic acid (1) and pterulone (2), two novel halogenated antibiotics, were isolated from fermentations of Pterula sp. 82168. Both compounds exhibited significant antifungal and weak or no cytotoxic activities. 1 and 2 are effective inhibitors of eucaryotic respiration. The target of the antibiotics resides within the mitochondrial NADH:ubiquinone oxidoreductase (complex I).
The furan approach to oxygenated natural products. Total synthesis of (+)-KDO (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe furan approach to oxygenated natural products. Total synthesis of (+)-KDOStephen F. Martin and Paul W. ZinkeCite this: J. Org. Chem. 1991, 56, 23, 6600–6606Publication Date (Print):November 1, 1991Publication History Published online1 May 2002Published inissue 1 November 1991https://pubs.acs.org/doi/10.1021/jo00023a028https://doi.org/10.1021/jo00023a028research-articleACS PublicationsRequest reuse permissionsArticle Views805Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Estimation of Stator Resistance in Direct Torque Control Synchronous Motor Drives (2014)

Direct torque control (DTC) is a high-performance method that provides effective control of stator flux modulus and electromagnetic torque of electric motors. However, error in estimation of stator resistance significantly degrades the performance of a DTC drive system, especially for a synchronous motor. This paper discusses the problems associated with the error in stator resistance and proposes an analytical approach to investigate its effect on the actual and estimated variables of a synchronous motor. Based on how this error affects the estimated angle between the stator flux and current vectors, a method to track stator resistance variations is proposed. The presented analytical method and the proposed stator resistance estimation are validated using simulation and experimental case studies.
A Facile Approach to Defect-Free Vinylene-Linked Benzothiadiazole−Thiophene Low-Bandgap Conjugated Polymers for Organic Electronics (2009)

A facile approach to synthesize vinylene-linked donor−acceptor conjugated polymers is reported and can now be considered for general use. This approach led to a low-bandgap, structurally defect-free vinylene-linked benzothiadiazole−thiophene (PTVBT) polymer and its corresponding model compound bisTVBT using a set of three reactions: Heck coupling, Hunsdiecker reaction, and Suzuki coupling reaction. The polymer and the model compound were fully characterized by 1H and 13C NMR, IR, and elemental analysis. GPC revealed that the number-average molecular weights of PTVBT ranged from 20 000 to 31 000 Da and polydispersity indices from 1.7 to 2.4. Thermal analysis demonstrated that the polymer was stable up to 380 °C under nitrogen without decomposition. Spectroelectrochemical results showed the PTVBT had an optical bandgap of 1.5 eV and was both p- and n-type dopable. The energetic positions of the band edges were determined by cyclic voltammetry and differential pulse voltammetry and suggested that the polymer had a HOMO level at 5.2−5.4 eV, as well as a LUMO level at 3.5−3.6 eV, which renders a strong tendency for photoinduced charge transfer to fullerene acceptors. The polymer has been investigated as an electron donor in photovoltaic devices in blends with PCBM ([6,6]-phenyl C61-butyric acid methyl ester) as an electron acceptor. Power conversion efficiencies ∼0.2−0.3% have been obtained with an open-circuit voltage (Voc) of 0.61 V and a short-circuit current density (Isc) of 1.6 mA/cm2. The relatively low conversion efficiencies may result from low content of polymer in the blends and phase separation as revealed by AFM studies.
Did early Renaissance masters use optical projections while painting? Image analytic, optical and historical rebuttals to the Hockney theory (2004)

We apply image and optical analyses to key works to test the recent claim that some Renaissance artists as early as 1420 used projections while executing their paintings. Our rigorous results, together with a careful consideration of the historical documentary record and putative “re-enactments,” show that the optical projection claim is implausible for adduced paintings of the 15th century.
Integrating Crop Models into GIS to Predict Regional Crop Yield (2002)

Interfacing crop models with GIS is a powerful tool to provide crop yield forecasting across a geographicregion. The peanut simulation model PNUTGO has been integrated into ArcView GIS to simulate regional peanut yield inthis study. The system is fully integrated in that it allows user defined management inputs in GIS environment and dynamicsimulation and output analysis. Spatial weather inputs can be generated by an Access database interface that isdynamically linked to the system. Soil and crop land use information were predetermined and can be added to the systemas plug-in database. Therefore, user-required inputs and parameterizations have been minimized. This paper describes thebasic components and features of the simulation system and presents an example application to demonstrate the utility ofthe application in estimating regional peanut yield in South Carolina.
EMI suppression effects of a magnetic composite sheet with an internal conductive layer (2003)

With continuing development in the field of digital high-frequency devices, the problems of EMI in the quasi-microwave band are becoming increasingly serious. The authors have previously proposed a noise suppressing sheet made of soft magnetic metal flakes, and its efficacy as a countermeasure for high frequency noise has been confirmed. This sheet is already in practical use in cellular-phones and notebook PCs, installed near radiation sources. This paper describes EMI suppression effects achieved with the use of a new EMI suppression sheet with an internal conductive layer, designed for use in interference suppression between printed circuit boards.