gebhart/patrepeval huggingface dataset:
Transcriptional profiling reveals a subset of human breast tumors that retain wt TP53 but display mutant p53‐associated features (2020)

TP53 gene mutations are very common in human cancer. While such mutations abrogate the tumor suppressive activities of the wild-type (wt) p53 protein, some of them also endow the mutant (mut) protein with oncogenic gain of function (GOF), facilitating cancer progression. Yet, p53 may acquire altered functionality even without being mutated; in particular, experiments with cultured cells revealed that wtp53 can be rewired to adopt mut-like features in response to growth factors or cancer-mimicking genetic manipulations. To assess whether such rewiring also occurs in human tumors, we interrogated gene expression profiles and pathway deregulation patterns in the METABRIC breast cancer (BC) dataset as a function of TP53 gene mutation status. Harnessing the power of machine learning, we optimized a gene expression classifier for ER+Her2- patients that distinguishes tumors carrying TP53 mutations from those retaining wt TP53. Interestingly, a small subset of wt TP53 tumors displayed gene expression and pathway deregulation patterns markedly similar to those of TP53-mutated tumors. Moreover, similar to TP53-mutated tumors, these 'pseudomutant' cases displayed a signature for enhanced proliferation and had worse prognosis than typical wtp53 tumors. Notably, these tumors revealed upregulation of genes which, in BC cell lines, were reported to be positively regulated by p53 GOF mutants. Thus, such tumors may benefit from mut p53-associated activities without having to accrue TP53 mutations.
Realization of Diamond/Metal Laminates through Brazing of Freestanding Diamond Foils (2019)

Freestanding diamond foils are an exceptionally strong material. A major problem that prevents industrial use is their inherent brittleness. We here present a first approach to introduce metallic interlayers into a diamond matrix by brazing stacks of diamond foils. This represents a potential route to toughen the material. Laminates of two and four layers of diamond were produced from the same batch of diamond foils. A first attempt to approximate the bending strength of this new material was made using a Ball-on-three-Balls (B3B) setup. Substantially higher strength values were achieved for the laminates compared to the freestanding (monolithic) foil.
Understanding the Improved Activity of Dendritic Sn1Pb3 Alloy for the CO2 Electrochemical Reduction: A Computational–Experimental Investigation (2020)

An alloy of Sn and Pb (Sn1Pb3) was prepared by electrodeposition at large negative current. The deposit is porous, with a honeycomb-like primary structure and a dendritic-like secondary structure. The onset potential for the electroreduction of CO2 is 80 mV lower on dendritic Sn1Pb3 as compared to dendritic Pb. The faradaic efficiency for formate formation is close to 100% in the potential range from −1.16 to −1.56 V vs. SHE. Density functional theory (DFT) computations were performed to uncover the origin of the decrease in the onset potential upon alloying Pb with Sn. Explicit treatment of water molecules in DFT calculations turns out as crucial to achieve an agreement with experimentally measured onset potentials.
Regulation of Cardiolipin Biosynthesis in H9c2 Cardiac Myoblasts by Cytidine 5′-Triphosphate (1996)

The regulation of cardiolipin biosynthesis by CTP in H9c2 cardiac myoblasts was investigated. H9c2 cells were incubated in the presence of cyclopentenylcytosine which is converted to cyclopentenylcytosine-triphosphate, a potent and specific inhibitor of CTP synthetase. Incubation of cells for 12 h with cyclopentenylcytosine reduced the cellular pool size of CTP to less than 10% of control cells but did not influence the pool size of other nucleotides. The de novo biosynthesis of phosphatidylcholine from [methyl-3H]choline, phosphatidylethanolamine from [1-3H]ethanolamine, and biosynthesis of all glycerol containing phospholipids from [U-14C]glycerol or [1,3-3H]glycerol were reduced approximately 50% after preincubation of the cells with cyclopentenylcytosine. In contrast, radioactive glycerol accumulated in phosphatidic acid, diacylglycerol, and triacylglycerol in cyclopentenylcytosine-treated cells compared with controls suggesting a re-routing of phospholipid biosynthesis away from CTP utilizing reactions toward neutral lipid synthesis. The de novo biosynthesis of all phospholipids was restored to control levels by addition of cytidine to the medium which elevated CTP levels. Cyclopentenylcytosine did not affect the in vitro enzyme activities involved in cardiolipin biosynthesis in these cells. In addition, the resynthesis of cardiolipin and most phospholipids from [1-14C]linoleic acid was not affected by cyclopentenylcytosine. Our findings indicate that the cellular CTP level may regulate cardiolipin biosynthesis in H9c2 cardiac myoblasts and support the notion that the cellular CTP level may be a universal signal/switch for all phospholipid biosynthesis in eukaryotic cells.
Co-doping effect of Eu3+ and Sm3+ ions on the red emission from the high-K material SrHfO3 (2014)

In our search for a new red phosphor, we investigated the photoluminescence from the high-K material SrHfO3 with co-doping of Eu3+ and Sm3+. We found that the red emission from co-doped SrHfO3 depended strongly on the doping concentrations of Eu3+ and Sm3+ and that the intensity was strongest for Eu3+ 1% (x = 0.01) and Sm3+ 1% (y = 0.01) co-doping. We were explain our findings in terms of the energy transfer between the Eu3+ and the Sm3+ ions, and we compared our red phosphor with other commercially-used ones.
Chicken Collagen Hydrolysate Protects Rats from Hypertension and Cardiovascular Damage (2010)

We previously reported that chicken collagen hydrolysate (CCH) has strong angiotensin I converting enzyme (ACE) inhibitory activity and antihypertensive effects on spontaneously hypertensive rats. Here, we investigated the chronic therapy effects of CCH on blood pressure and vascular relaxation in a cardiovascular damage model of Wistar-Kyoto rats induced by N-nitro-l-arginine methyl ester (L-NAME). Following co-treatment with CCH for 4 weeks, the increment of systolic blood pressure was suppressed significantly. At 8 weeks, the vasorelaxation of thoracic aorta increased significantly, and cardiovascular damage was ameliorated. The concentration of soluble intercellular adhesion molecule-1 (ICAM-1) in blood was reduced significantly by long-term administration of CCH, whereas the nitric oxide concentration was increased significantly at 1 hour post-treatment. The results suggest that beneficial effects of CCH result from antihypertensive function, but also from inhibition of cardiovascular damage to the endothelial cells via its ACE inhibitory activity and regulation of nitric oxide and ICAM-1, which suggests that CCH may be useful as a medicinal food for patients with cardiovascular disease.
ChemInform Abstract: Ordered Conducting Films of the Inorganic Polymer (LiMo3Se3)n Cast from Solution. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Towards the Total Synthesis of Saponaceolides: Synthesis of cis-2,4-Disubstituted 3,3-Dimethylmethylenecyclohexanes. (1999)

Controlling diastereoselectivity by metal coordination: In the case of 3,3-dimethylmethylenecyclohexanes 2-a structural unit present in many interesting natural products-the thermodynamically less stable cis-2,4-disubstituted compounds become available through a cyclization event wherein the configuration is determined by a carbopalladation step. Both the cycloisomerization of 1,7-enynes 1 and the intramolecular Heck-type reaction of compounds of type 3 provide the cis product as the major product.
Silencer and Enhancer Regions in the Human CD95 (Fas/APO-1) Gene with Sequence Similarity to the Granulocyte-Macrophage Colony-Stimulating Factor Promoter: Binding of Single Strand-Specific Silencer Factors and AP-1 and NF-AT-Like Enhancer Factors (1998)

The CD95 (Fas/APO-1) apoptosis receptor is expressed in a variety of tissues and transiently upregulated in lymphocytes during activation-induced cell death. A silencer (S1; -1035 to -1008) and an adjacent enhancer (E1; -1007 to -964) region have been mapped in the CD95 gene. The S1 region shows similarity to binding sites for the transcriptional repressor NF-GMb, which prefers binding to single-stranded DNA. The E1 contains an everted repeat of two CATTA/T elements spaced by 2 bp (ER2). Such motifs are directly repeated in the CLE0 region of the human granulocyte-macrophage colony-stimulating factor (huGM-CSF) promoter. A motif (TGATGTCA) which matches a CREB site and is similar to an AP-1 site is embedded within ER2. Sequence-specific binding of nuclear factors to single-stranded S1 probes involved, to some extent, a central heptamer motif (ATCCAAA) also present in E1. Competition binding studies suggested that AP-1 or AP-1 components, as well as factors related, but not identical, to NF-AT bound to E1 probes. S1-binding-proteins/complexes of 47, 77, and 100 kDa were detected by Southwestern analysis and ultraviolet crosslinking. Complexes of 70 and 80 kDa were formed with a double-stranded E1 probe in UV-crosslinking, whereas Southwestern analysis with this probe revealed single binding species of 59 and 113 kDa. ER2 autonomously enhanced transcription from the heterologous HSV tk promoter in a cell type-specific manner only in the absence of the S1 region. This analysis has identified a small region in the CD95 gene containing adjacent opposing regulatory elements which are likely to be involved in the cell type- and activation state-specific gene expression under physiologic conditions.
Effect of Ageing on Quality Index of an Al – Cu Casting Alloy (2002)

Developed by Drouzy et al. [1] the concept of the quality index, Q, is capable of expressing the materials mechanical quality in terms of a single numerical parameter. The performance of the alloy can be quantitatively expressed in terms of Q, to show performance improvements or otherwise.The strength of Aluminium-Copper casting alloys is dependant on the copper (Cu) and magnesium (Mg) for given heat treatment while the tensile ductility may be affected by the iron (Fe) and porosity content, etc. When different process routes are followed or the chemical composition is changed, the balance between the different factors affecting the strength and ductility of the alloys usually changes. Hence the quality index can be a very useful tool to assess any improvement or otherwise in the mechanical properties of the alloy.Quality index charts exist for A356 and A357 alloys, but they need to be developed for alloy A206, which is one of the goals of this work. The other will involve exploring a range of heat treatments in an attempt of optimising the strength and ductility of the material.
Online Human Interaction Detection and Recognition With Multiple Cameras (2016)

We address the problem of detecting and recognizing online the occurrence of human interactions as seen by a network of multiple cameras. We represent interactions by forming temporal trajectories, coupling together the body motion of each individual and their proximity relationships with others, and also sound whenever available. Such trajectories are modeled with kernel state-space (KSS) models. Their advantage is being suitable for the online interaction detection, recognition, and also for fusing information from multiple cameras, while enabling a fast implementation based on online recursive updates. For recognition, in order to compare interaction trajectories in the space of KSS models, we design so-called pairwise kernels with a special symmetry. For detection, we exploit the geometry of linear operators in Hilbert space, and extend to KSS models the concept of parity space, originally defined for linear models. For fusion, we combine KSS models with kernel construction and multiview learning techniques. We extensively evaluate the approach on four single view publicly available data sets, and we also introduce, and will make public, a new challenging human interactions data set that we have collected using a network of three cameras. The results show that the approach holds promise to become an effective building block for the analysis of real-time human behavior from multiple cameras.
Core-Layer Performance Comparison of ATSC 3.0 LDM-MIMO System in Mobile Environment (2022)

This paper presents a core-layer performance comparison of the ATSC 3.0 LDM-MIMO system in a mobile environment. A field trial is conducted to compare system performance with different core-layer transmission polarization scenarios. The field trial results show that the vertical polarization is suitable for mobile broadcasting on the ATSC 3.0 LDM-MIMO system.
High-Mobility Stable 1200-V, 150-A 4H-SiC DMOSFET Long-Term Reliability Analysis Under High Current Density Transient Conditions (2014)

For SiC DMOSFETs to obtain widespread usage in power electronics their long-term operational ability to handle the stressful transient current and high temperatures common in power electronics needs to be further verified. To determine the long-term reliability of a single 4H-SiC DMOSFET, the effects of extreme high current density were evaluated. The 4H-SiC DMOSFET has an active conducting area of 40 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , and is rated for 1200 V and 150 A. The device was electrically stressed by hards-witching transient currents in excess of four times the given rating (>600 A) corresponding to a current density of 1500 A/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Periodically throughout testing, several device characteristics including R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DS(on)</sub> and VG S(th) were measured. After 500 000 switching cycles, the device showed a 6.77% decrease in R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DS (on)</sub> , and only a 132-mV decreased in V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">G S(th)</sub> . Additionally, the dc characteristics of the device were analyzed from 25 to 150 °C and revealed a 200-mV increase in on-state voltage drop at 20 A and a 2-V reduction in V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">G S(th)</sub> at 150 °C. These results show this SiC DMOSFET has robust long-term reliability in high-power applications that are susceptible to pulse over currents, such as pulsed power modulators and hard-switched power electronics.
Electron beam weldability of a group IAB iron meteorite (2014)

Electron beam welding, first demonstrated in space on Soyuz 6, and later on the Skylab mission, appears to be the leading candidate for welding structures in space since it is ideally suited for the vacuum of space. These pioneering welding experiments were performed on terrestrial materials such as aluminium, titanium and stainless steel, and the results showed no significant differences from welds made on Earth. Future applications for welding in space include repair of existing structures, research and development activities, and construction of new structures. However, large scale space construction will need to exploit natural space resources for raw materials, and iron is expected to be a key element due to its availability in near-Earth objects. Here, we investigate the weldability of an extraterrestrial group IAB iron meteorite in its native state, and show that further welding innovation is required to directly join meteoritic material due to inherent non-metallic impurities that lead to weld cracking.
Vanadium Octacyanoniobate-Based Magnet with a Curie Temperature of 138 K (2009)

In this work, we prepared a three-dimensional vanadium octacyanoniobate-based magnet, K(0.10)V(II)(0.54)V(III)(1.24)[Nb(IV)(CN)(8)].(SO(4))(0.45).6.8H(2)O. This compound exhibits ferrimagnetism with a Curie temperature of 138 K, in which the sublattice magnetizations of V(II) (S = (3)/(2)) and V(III) (S = 1) are antiparallelly ordered to that of Nb(IV) (S = (1)/(2)). The estimated superexchange interaction constants of V(II)-Nb(IV) and V(III)-Nb(IV) are -51 and -25 cm(-1), respectively.
Development of High Strength Optical Fiber Waveguides Using Residual Surface Compression (1979)

Abstract : The primary objective of this project was to maximize the compressive strengthening obtained in low loss fibers made by the molecular stuffing process. The process being the doping of a porous high silica glass rod made by a phase separation and leaching process. The rod is subsequently sintered to form a solid glass preform form which fibers may be drawn. The ultimate goal being a fiber having greater than 100 ksi surface compression and loss less than 10 dB/km. As a major part of this effort we have characterized the strengthening effects of compression and demonstrated that even moderate compression can be of value in many applications. Optical losses less than 10 dB/km are obtainable using molecular stuffing and we were able to produce preforms having greater than 75 ksi compression. Preforms and fibers having very high compression are difficult to produce and thus may not provide a practical method of dramatically increasing fiber strength. Surface compression on the order of 30 ksi is relatively easy to obtain, however, and compression of this magnitude can have significant effects on fatigue failure in many applications. We were able to demonstrate that fibers having surface compression showed no strength degradation when aged under load in air as long as the tensile load was less in magnitude than that of the compression. In fact, the strength of abraded samples was observed to improve with time.
Monitoring bubble growth in supersaturated blood and tissue ex vivo and the relevance to marine mammal bioeffects (2005)

There have been several recent reports that active sonar systems can lead to serious bioeffects in marine mammals, particularly beaked whales, resulting in strandings, and in some cases, to their deaths. We have devised a series of experiments to determine the potential role of low-frequency acoustic sources as a means to induce bubble nucleation and growth in supersaturated ex vivo bovine liver and kidney tissues, and blood. Bubble detection was achieved with a diagnostic ultrasound scanner. Under the conditions of this experiment, supersaturated tissues and blood led to extensive bubble production when exposed to short pulses of low frequency sound.
Private Over-Threshold Aggregation Protocols over Distributed Datasets (2016)

In this paper, we revisit the private over-threshold data aggregation problem. We formally define the problem's security requirements as both data and user privacy goals. To achieve both goals, and to strike a balance between efficiency and functionality, we devise an efficient cryptographic construction and its proxy-based variant. Both schemes are provably secure in the semi-honest model. Our key idea for the constructions and their malicious variants is to compose two encryption functions tightly coupled in a way that the two functions are commutative and one public-key encryption has an additive homomorphism. We call that double encryption. We analyze the computational and communication complexities of our construction, and show that it is much more efficient than the existing protocols in the literature. Specifically, our protocol has linear complexity in computation and communication with respect to the number of users. Its round complexity is also linear in the number of users. Finally, we show that our basic protocol is efficiently transformed into a stronger protocol secure in the presence of malicious adversaries, and provide the resulting protocol's performance and security analysis.
Performance analysis of replicated self-routing switch model with multiple priority classes (1999)

In this paper, we propose the input-buffered replicated self-routing switch model with multiple priority classes in order to satisfy different demands of several traffic cell classes. The priority path setup discipline at each switching element is proposed in order to perform priority path setup when two cells of higher- and lower-priority classes arrive at the switching element. The nonpreemptive priority discipline at the external input buffers outside the switch for each class of cells is employed so that a higher-priority cell is served first at the head of the line (HOL), whereas it has to wait in the buffer until the completion of the low-priority cell in service. We analyze the system delay of every priority class cell for the random sharing model which distributes the cells randomly on the R planes, as well as the alternate sharing model which avoids contentions in the first log2R stages of each plane which serves Bernoulli arrival cells. Furthermore, when the buffer size for high-priority cells is limited, we consider the relation between the cell loss probability and input buffer sizes for two classes, and obtain the proper buffer size for the high-priority cells by computer simulation. It is seen that the proposed model is effective in showing the priority for different class cells. © 1999 Scripta Technica, Electron Comm Jpn Pt 1, 82(7): 1–11, 1999
Significance of syncope in patients with Alzheimer's disease treated with cholinesterase inhibitors (2003)

We describe three cases of patients with Alzheimer's disease who presented with cardiac syncope soon after initiation of a cholinesterase inhibitor therapy (donepezil). Bradyarrhythmia was documented in two patients, considered probable in one, and was presumed related to the cholinergic therapy. Pacemaker implantation seemed justified rather than donepezil cessation. More over, it permitted an increase in donepezil dosage.
Cache conscious data layout organization for embedded multimedia applications (2001)

Cache misses form a major bottleneck for real-time multimedia applications due to the off-chip accesses to the main memory. This results in both a major access bandwidth overhead (and related power consumption) as well as performance penalties. In this paper, we propose a new technique for organizing data in the main memory for data dominated multimedia applications so as to reduce majority of the conflict cache misses. The focus of this paper is on the formal and heuristic algorithms we use to steer the data layout decisions and the experimental results obtained using a prototype tool. Experiments on real-life demonstrators illustrate that we are able to reduce up to 82% of the conflict misses for applications that are already aggressively transformed at the source-level. At the same time, we also reduce the off-chip data accesses by up to 78% and combined with address optimizations we are able to reduce the execution time. Thus our approach is complimentary to the more conventional way of reducing misses by reorganizing the execution order.