gebhart/patrepeval huggingface dataset:
Association between gastrointestinal perforation and patent ductus arteriosus in extremely-low-birth-weight infants: A retrospective study of our decade- long experience (2023)

Abstract Purpose Management of persistently patent ductus arteriosus (PDA) in extremely-low-birth-weight infants (ELBWIs) requires attention due to the risk of tissue hypoperfusion. We investigated the association between PDA and gastrointestinal perforation. Methods We performed a retrospective chart review from 2012 to 2021. Preterm (≤ 32 weeks) ELBWIs with PDA after birth who developed necrotizing enterocolitis (NEC), focal intestinal perforation (FIP), and idiopathic gastric perforation were included; ELBWIs with congenital heart disease were excluded. Data were analyzed using chi-squared tests with Yates' correction, and Student's t -test. Results Five hundred thirty-five preterm ELBWIs were analyzed, including 20 with NEC, 22 with FIP, and 1 with gastric perforation. In NEC and FIP, the ductus arteriosus remained open in 40% (4/10) and 63.6% (14/22) of cases, respectively, and cyclo-oxygenase inhibitor treatment showed poor efficacy ( p = 0.492 and 0.240). The incidence of perforation in NEC (4/9 vs. 6/11, p = 0.653), mortality in NEC (3/4 vs. 3/6, p = 0.895) and FIP (6/14 vs. 3/8, p = 0.838) did not differ according to whether the PDA persisted or resolved. Conclusion The presentation of PDA did not affect mortality or morbidity of ELBWIs. However, it is essential to consider the possibility of gastrointestinal perforation due to decreased organ blood flow caused by ductal steal.
Low-resistance Al-based reflectors for high-power GaN-based flip-chip light-emitting diodes (2005)

We report on the formation of high-quality p-type Al-based ohmic reflectors using Ag (3nm)∕indium tin oxide (ITO)(100nm) interlayers for use in high-power flip-chip light-emitting diodes (LEDs). The Ag∕ITO interlayers are first annealed at temperatures of 530 and 630°C for 1min in air, after which Al reflectors (200nm thick) are deposited and subsequently annealed at 330°C for 5min in a vacuum. It is shown that the annealed Ag∕ITO∕Al contacts give specific contact resistances as low as ∼10−5Ωcm−2 and reflectance of ∼85% at a wavelength of 460nm, which are much better than those of oxidized Ni∕Au schemes. LEDs fabricated with the annealed Ag∕ITO∕Al p-type electrodes give forward-bias voltages of 3.29–3.37V at injection current of 20mA.
THE NUCLEAR MATRIZ OF THE PROSTATE CONTAINS ACCEPTOR SITES FOR ANDROGEN RECEPTORS (1983)

In cell-free binding experiments, androgen receptors of rat ventral prostate cytosol bound with high affinity (Kd = 10(-10) M) to a saturable number of sites (acceptors) associated with the nuclear matrix of the prostate. This binding was dependent on the presence of an activated androgen-receptor complex. In addition, the binding was tissue-specific, since liver nuclear matrix, in contrast, contained only 15-20% as many acceptors for androgen receptors as the prostate nuclear matrix. The prostate nuclear matrix contained approximately 75% of the number of total nuclear acceptor sites. Matrix-associated acceptor sites appear to be associated with the internal RNA-protein network of the nuclear matrix since the peripheral lamina component of the matrix bound only 30% as many receptors as the intact nuclear matrix.
Extracorporeal Carbon Dioxide Removal: The Future of Lung Support Lies in the History (2012)

Extracorporeal organ support in patients with dysfunction of vital organs like the kidney, heart, and liver has proven helpful in bridging the patients to recovery or more definitive therapy. Mechanical ventilation in patients with respiratory failure, although indispensable, has been associated with worsening injury to the lungs, termed ventilator-induced lung injury. Application of lung-protective ventilation strategies are limited by inevitable hypercapnia and hypercapnic acidosis. Various alternative extracorporeal strategies, proposed more than 30 years ago, to combat hypercapnia are now more readily available. In particular, the venovenous approach to effective carbon dioxide removal, which involves minimal invasiveness comparable to renal replacement therapy, appears to be very promising. The clinical applications of these extracorporeal carbon dioxide removal therapies may extend beyond just lung protection in ventilated patients. This article summarizes the rationale, technology and clinical application of various extracorporeal lung assist techniques available for clinical use, and some of the future perspectives in the field.
ChemInform Abstract: A Versatile Synthesis of Novel pan‐PIM Kinase Inhibitors with Initial SAR Study. (2015)

Abstract The synthesis of a series of novel inhibitors of the PIM family of kinases is described.
A High Performance Packet Core for Next Generation Cellular Networks (2017)

Cellular traffic continues to grow rapidly making the scalability of the cellular infrastructure a critical issue. However, there is mounting evidence that the current Evolved Packet Core (EPC) is ill-suited to meet these scaling demands: EPC solutions based on specialized appliances are expensive to scale and recent software EPCs perform poorly, particularly with increasing numbers of devices or signaling traffic.
Supplementary Materials and Methods from Anagrelide for Gastrointestinal Stromal Tumor (2023)

&lt;p&gt;Supplementary Materials and Methods&lt;/p&gt;
The tensile strength of uterosacral ligament sutures: A comparison of vaginal and laparoscopic techniques (2003)

These suturing techniques appear to be equal in tensile strength.
Mechanical Admittance Realization Control Based on Feedforward Compensation for Fine Realization of Impedance (2017)

This paper proposes a new admittance realization control system based on feedforward compensation for high-stiffness environments. In conventional admittance realization control systems, the poles of the control system can be designed using any design method. However, zeros are placed on the right side of the dominant pole in the pole placement diagram when the environmental stiffness and viscosity values are large. These zeros placed on the right side of the dominant pole deteriorate the frequency response.
Proceedings of the 17th International Conference on Informatics in Control, Automation and Robotics, ICINCO 2020, Lieusaint, Paris, France, July 7-9, 2020 (2020)

International audience
REGULATED INHIBITION OF COAGULATION BY PORCINE ENDOTHELIAL CELLS EXPRESSING P-SELECTIN-TAGGED HIRUDIN AND TISSUE FACTOR PATHWAY INHIBITOR FUSION PROTEINS (1999)

Novel anticoagulant molecules may prove useful therapeutic agents for gene therapy in thrombotic disease and postangioplasty or for transgenic expression in animals whose organs may be used for clinical xenotransplantation. Expression in vascular endothelial cells may be regulated by inclusion of P-selectin cytoplasmic sequence, to restrict cell surface expression to activated endothelium.
Spin Splitting, Fermi Energy Changes, and AnomalousgShifts in Single-Crystal and Pyrolytic Graphite (1970)

This Letter reports the first observation of spin-split Landau levels in graphite. These are observed in both natural single crystals and in pyrolytic samples. Experimental splittings are compared with the theory of McClure and Yafet. Discrepancy between theory and experiment is partially accounted for by large shifts in the Fermi energy with field.
Jet Production via Strongly Interacting Color-Singlet Exchange inpp¯Collisions (1996)

A study of the particle multiplicity between jets with large rapidity separation has been performed using the D0 detector at the Fermilab Tevatron $p\overline{p}$ Collider operating at $\sqrt{s}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}1.8\mathrm{TeV}$. A significant excess of low-multiplicity events is observed above the expectation for color-exchange processes. The measured fractional excess is $1.07\ifmmode\pm\else\textpm\fi{}0.10(\mathrm{stat}{)}_{\ensuremath{-}0.13}^{+0.25}(\mathrm{syst})%$, which is consistent with a strongly interacting color-singlet (colorless) exchange process and cannot be explained by electroweak exchange alone. A lower limit of $0.80%$ (95% C.L.) is obtained on the fraction of dijet events with color-singlet exchange, independent of the rapidity gap survival probability.
Absorptive propagation effects in femtosecond four-wave-mixing (2006)

Propagation distortions are examined for frequency resolved pump-probe (FRPP) signals in the perturbative limit. Propagation distortions exhibit qualitative differences that depend on the system dynamics.
Two-Stream Neural Networks for Tampered Face Detection (2018)

We propose a two-stream network for face tampering detection. We train GoogLeNet to detect tampering artifacts in a face classification stream, and train a patch based triplet network to leverage features capturing local noise residuals and camera characteristics as a second stream. In addition, we use two different online face swapping applications to create a new dataset that consists of 2010 tampered images, each of which contains a tampered face. We evaluate the proposed two-stream network on our newly collected dataset. Experimental results demonstrate the effectiveness of our method.
A Biologically Inspired, Functionally Graded End Effector for Soft Robotics Applications (2017)

Soft robotic actuators offer many advantages over their rigid counterparts, but they often are unable to apply highly localized point loads. In contrast, many invertebrates have not only evolved extremely strong "hybrid appendages" that are composed of rigid ends that can grasp, puncture, and anchor into solid substrates, but they also are compliant and resilient, owing to the functionally graded architecture that integrates rigid termini with their flexible and highly extensible soft musculatures. Inspired by the design principles of these natural hybrid appendages, we demonstrate a synthetic hybrid end effector for soft-bodied robots that exhibits excellent piercing abilities. Through the incorporation of functionally graded interfaces, this design strategy minimizes stress concentrations at the junctions adjoining the fully rigid and soft components and optimizes the bending stiffness to effectively penetrate objects without interfacial failure under shear and compressive loading regimes. In this composite architecture, the radially aligned tooth-like elements apply balanced loads to maximize puncturing ability, resulting in the coordinated fracture of an object of interest.
Technical Evaluation of the Consequence of HCDP Upsets From Gas Producers Along Pipeline Laterals (2016)

Natural gas accepted into the pipeline at receipt points is subject to gas quality specifications to ensure that downstream laterals and mainlines are not subjected to operational upsets, and that the integrity of the pipeline and related facilities is not compromised. One of the specifications is the maximum hydro-carbon dew point (HCDP) at the pipeline operating pressure. Occasionally, gas plants encounter operational upsets that result in a higher HCDP. If the HCDP exceeds the ground temperature, condensation of heavier hydrocarbon can potentially occur along the lateral. Ideally, after an upset has been detected and the producer has been shut in, the lateral would be pigged to remove the condensed hydrocarbons. However, if the lateral is unpiggable, the only way to remove the liquids is to evaporate them into a flow of dryer gas. The present paper compares two potential courses of action which may be taken after a high HCDP is detected at a receipt point on an unpiggable line: (a) flowing dry gas from the producer after the source of upset is corrected, or (b) pulling dryer gas back from the operator’s mainline through the lateral to the producer. In order to determine the most appropriate course of action for a given upset, the state of the lateral during and after the upset must first be accurately quantified. In the present paper, the state was modelled based on the governing equations of fluid flow including heat transfer and condensation, the GERG-2008 equation of state, and empirical liquid-hold-up equations. The effect of flow parameters (e.g., gas composition, lateral elevation profile, ground temperature, etc.) on the upset severity is explored. Subsequently, models for forward flow and pull back are presented, and the criteria for selecting when either course of action is appropriate are discussed.
The role of radiation therapy in the treatment of small cell lung cancer (1985)

Patients with small cell lung cancer (SCLC) are candidates for aggressive therapy because of their potential for long-term survival, especially patients with limited-stage disease. Although no treatment protocol can be considered "standard", the best results in limited-stage SCLC appear to be produced by a combination of chemotherapy and thoracic irradiation. Ongoing protocols testing the efficacy of thoracic irradiation should be able to settle question of the optimal treatment approach in limited-stage SCLC over the next 1 to 2 years. Careful attention to volume treated and the use of shrinking fields produce the best results with the minimum of toxicity. Treatment of extensive-stage SCLC has not been substantially improved to date with the addition of local or systemic irradiation. Prophylactic cranial irradiation reduces the incidence of CNS failure in SCLC and should be given, at a minimum, to patients achieving complete response status. Whether patients with partial response should also receive prophylactic cranial irradiation remains controversial. Finally, half-body radiation in SCLC is an experimental research technique that has shown some promise but remains quite toxic when combined with systemic chemotherapy.
Simultaneous Catabolite Repression between Glucose and Toluene Metabolism in Pseudomonas putida Is Channeled through Different Signaling Pathways (2007)

Pseudomonas putida KT2440(pWW0) can use toluene via the TOL plasmid-encoded catabolic pathways and can use glucose via a series of three peripheral chromosome-encoded routes that convert glucose into 6-phosphogluconate (6PG), namely, the glucokinase pathway, in which glucose is transformed to 6PG through the action of glucokinase and glucose-6-phosphate dehydrogenase. Alternatively, glucose can be oxidized to gluconate, which can be phosphorylated by gluconokinase to 6PG or oxidized to 2-ketogluconate, which, in turn, is converted into 6PG. Our results show that KT2440 metabolizes glucose and toluene simultaneously, as revealed by net flux analysis of [(13)C]glucose. Determination of glucokinase and gluconokinase activities in glucose metabolism, gene expression assays using a fusion of the promoter of the Pu TOL upper pathway to 'lacZ, and global transcriptomic assays revealed simultaneous catabolite repression in the use of these two carbon sources. The effect of toluene on glucose metabolism was directed to the glucokinase branch and did not affect gluconate metabolism. Catabolite repression of the glucokinase pathway and the TOL pathway was triggered by two different catabolite repression systems. Expression from Pu was repressed mainly via PtsN in response to high levels of 2-dehydro-3-deoxygluconate-6-phosphate, whereas repression of the glucokinase pathway was channeled through Crc.
Measurement of Electron-phonon Interactions Through Large-amplitude Phonon Excitation (1989)

Contains an introduction and report on one research project.
Design and Non‐Lithographic Fabrication of Light Trapping Structures for Thin Film Silicon Solar Cells (2010)

A self-assembled light trapping structure is numerically designed on the backside of thin film silicon solar cells and fabricated by using porous alumina as a template. We demonstrate this structure can effectively increase the optical absorption and thus improve the solar cell performances. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Interfaces between Molecular and Polymeric “Metals”: Electrically Conductive, Structure‐Enforced Assemblies of Metallomacrocycles (1990)

Abstract The design, synthesis, characterization, and understanding of new molecular and macro‐molecular substances with “metal‐like” electrical properties represents an active research area at the interface of chemistry, physics, and materials science. An important, long‐range goal in this field of “materials by design” is to construct supermolecular assemblies which exhibit preordained collective phenomena by virtue of “engineered” interactions between molecular building blocks. In this review, such a class of designed materials is discussed which, in addition, bridges the gap between molecular and polymeric conductors: assemblies of electrically conductive metallomacrocycles. It is seen that efforts to rationally construct stacked metal‐like molecular arrays lead logically to structure‐enforced macromolecular assemblies of covalently linked molecular subunits. Typical building blocks are robust, chemically versatile metallophthalocyanines. The electrical optical, and magnetic properties of these metallomacrocyclic assemblies and the fragments thereof, provide fundamental information on the connections between local atomic‐scale architecture, electronic structure, and the macroscopic collective properties of the bulk solid.
Adenovirus-Based Vaccines Generate Cytotoxic T Lymphocytes to Epitopes of NS1 from Dengue Virus That Are Present in All Major Serotypes (2008)

Dengue virus (DENV) infection is an expanding global threat to public health. Effective vaccine and treatment approaches remain elusive. B cell-directed vaccines may be complicated by an antibody-dependent enhancement (ADE) phenomenon based on cross-serotype, nonneutralizing antibodies. We hypothesized that a CD8(+) T cell-directed genetic vaccine that targets a DENV nonstructural protein, NS1, could be a potential strategy to overcome the ADE barrier and accomplish cross-serotype protection. We selected an adenovirus-based vector as the dengue vaccine carrier. To bypass preexisting immunity to human adenoviruses and to improve vaccine efficacy, we created vaccine vectors, based on simian adenoviruses SAdV22 and SAdV25 as well as human adenovirus serotype 5, expressing the NS1 antigen of the Hainan strain, DENV serotype 2. An NS1 peptide library was screened to identify the immunodominant and functional epitope within the NS1 protein for H-2(d)-restricted CD8(+) T cells in BALB/c mice, using interferon-gamma enzyme-linked immunospot and intracellular cytokine-staining assays. Our study identified the 9-mer AGPWHLGKL (NS1(265273)) as the H-2(d)-restricted T cell epitope whose sequence is highly conserved among 26 strains of DENV serotypes 1, 2, 3, and 4, suggesting potential cross-serotype protection of NS1-directed genetic vaccines in the BALB/c model of DENV infection. Importantly, we characterized the cytokine profile of CD8(+) NS1-specific T cells in BALB/c mice vaccinated with HAdV-5-NS1, SAdV-22-NS1, and SAdV-25 NS1 and demonstrated the effective in vivo cytolytic killing capacity of CD8(+) T cells from SAdV-25-NS1-vaccinated mice.
Dexa-BEAM is not Effective in Patients with Relapsed or Resistant Aggressive High-Grade Non-Hodgkin's Lymphoma (1999)

The aim of the present study was to evaluate the feasibility and response of the Dexa-BEAM regimen as a salvage therapy followed by high-dose chemotherapy (HDCT) with peripheral blood stem cell transplantation (PBCST) in responding patients with high-grade relapsed or resistant aggressive non-Hodgkin's lymphoma (NHL). Sixteen pretreated patients (mean age 44, range 26-59) with relapsed (8) or resistant (8) NHL were treated with 1-4 cycles of Dexa-BEAM (dexamethasone, BCNU, etoposide, cytarabine, melphalan) in order to attain maximal response. Patients achieving complete response (CR) or partial response (PR) received HDCT with PBSCT. The conditioning regimen used was BEAM. Three patients achieved CR and one patient PR, resulting in an overall response rate of 25%. Three of four responding patients underwent high-dose chemotherapy and were successfully transplanted with autologous blood stem cells. Progressive disease developed in one patient after transplantation. Myelosuppression (WHO grade III- grade IV), the major side effect, was observed in all courses of Dexa-BEAM. Myelosuppression-related infection WHO grade IV occurred in four patients. The protocol was not well tolerated in this heavily pretreated group of patients with four severe myelosuppression-related infections WHO grade IV and one treatment-related death. The overall response rate in this study is not comparable to other salvage regimens published and led to the discontinuation of the trial. In conclusion Dexa-BEAM was only effective in a minority of patients with refractory or relapsed aggressive NHL and was not useful as a cytoreductive regimen prior to HDCT.
The Video Mesh: A Data Structure for Image-based Video Editing (2009)

This paper introduces the video mesh, a data structure for representing video as 2.5D "paper cutouts." The video mesh allows interactive editing of moving objects and modeling of depth, which enables 3D effects and post-exposure camera control. The video mesh sparsely encodes optical flow as well as depth, and handles occlusion using local layering and alpha mattes. Motion is described by a sparse set of points tracked over time. Each point also stores a depth value. The video mesh is a triangulation over this point set and per-pixel information is obtained by interpolation. The user rotoscopes occluding contours and we introduce an algorithm to cut the video mesh along them. Object boundaries are refined with perpixel alpha values. The video mesh is at its core a set of texture mapped triangles, we leverage graphics hardware to enable interactive editing and rendering of a variety of effects. We demonstrate the effectiveness of our representation with a number of special effects including 3D viewpoint changes, object insertion, and depth-of-field manipulation.
What Is Chronic or Persistent Diabetic Macular Edema and How Should It Be Treated? (2016)

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