gebhart/patrepeval huggingface dataset:
Synthesis of a Bone-Targeted Bortezomib with In Vivo Anti-Myeloma Effects in Mice (2018)

Multiple myeloma (MM) is the most common cancer affecting the bone and bone marrow and remains incurable for most patients; novel therapies are therefore needed. Bortezomib (Btz) is an FDA-approved drug for the treatment of patients with MM. However, its severe side effects require a dose reduction or the potential discontinuation of treatment. To overcome this limitation, we conjugated Btz to a bisphosphonate (BP) residue lacking anti-osteoclastic activity using a novel chemical linker and generated a new bone-targeted Btz-based (BP-Btz) proteasome inhibitor. We demonstrated that BP-Btz, but not Btz, bound to bone slices and inhibited the growth of MM cells in vitro. In a mouse model of MM, BP-Btz more effectively reduced tumor burden and bone loss with less systemic side effects than Btz. Thus, BP-Btz may represent a novel therapeutic approach to treat patients with MM.
System Support for Interactive Workspaces (2001)

While work has been done on connectivity, mobility and general rendezvous systems for ubiquitous computing environments, research has been hampered by the lack of higher level application abstractions. To identify what these might be, we constructed a prototype ubiquitous computing environment which we call an Interactive Workspace, and observed how application writers attempted to use its facilities. We also identify system support issues for ubiquitous computing that differ from their counterparts in &amp;quot;traditional&amp;quot; single-node computing, and use them to guide the design of a set of abstractions to support ubiquitous computing applications deployed in spaces such as ours. Our implemented prototype meta-operatingsystem, iROS, and several applications in daily use on top of it, suggest that we have made progress toward the goal of providing support for application-level ubiquitous computing abstractions in a way that is robust to transient failures, extensible, portable across installations, and easy to program. Finally, as we consider future work, we argue that the abstractions we identified---moving data around, moving interfaces around, and coordinating the behavior of existing monolithic applications---are fundamental to this style of ubiquitous computing generally.
Biosensors for landing creative intent (2023)

The motivation for use of biosensors in audiovisual media is made by highlighting problem of signal loss due to wide variability in playback devices. A metadata system that allows creatives to steer signal modifications as a function of audience emotion and cognition as determined by biosensor analysis.
Supplementary Figure 2 from Fhit Modulates the DNA Damage Checkpoint Response (2023)

Supplementary Figure 2 from Fhit Modulates the DNA Damage Checkpoint Response
Angle-dependent light scattering by highly uniform colloidal rod-shaped microparticles: Experiment and simulation (2016)

While extensive theoretical work has been devoted to analyzing scattering behavior for nonspherical particles, few experimental studies of the light-scattering properties of such particles are available, largely because of the difficulty of synthesizing such particles with uniform geometries. Here we report the synthesis of highly uniform, volume-equivalent rod-shaped colloidal particles prepared from their commercial spherical counterparts, on which we performed light scattering experiments as a function of scattering angle for micro rods with varying aspect ratio and volume. These results were compared to values calculated using the T-Matrix method. Good agreement with theoretical predictions was found for the experimentally measured scattering cross sections and the angular dependence of the scattering intensity. An increase in the forward scattering intensity is observed and predicted for particles with larger aspect ratios relative to their volume equivalent spheres, with only minor differences observed at both mid-range and backscattering angles. Furthermore, the light scattering results for the rod-shaped particles did not show the scattering fringes seen in scattering by the spheres, indicating that as three-dimensional symmetry is broken, the associated Lorenz–Mie resonances are strongly attenuated. This observation also was predicted by theory. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2016, 54, 1889–1895
Electrical and Mechanical Behavior of Aerosol Jet–Printed Gold on Alumina Substrate for High‐Temperature Applications (2023)

There is a growing interest in the development of microelectronics that can perform reliably and robustly at temperatures above 300 °C. Such devices require stable thermal properties, low thermal drift, and thermal cycling resistance. Conventional hybrid circuit technology demonstrates high‐temperature packages, but the high costs and lead time are significant drawbacks. In contrast, additive manufacturing processes, including aerosol jet printing (AJP), offer cost and time benefits, as well as 3D structures and embedded features. However, the properties and reliability of additive packaging materials at extreme temperatures are not well known. Herein, the reliability at temperatures up to 750 °C in terms of electrical performance and mechanical strength of aerosol jet printed gold thick films onto ceramic substrates are assessed. Thermal coefficient of resistance of printed gold films is measured. The electrical resistance stability and leakage current of printed gold structures are also characterized during over 100 h of aging at temperatures up to 750 °C. Finally, the mechanical adhesion strength of the printed gold films is evaluated after aging for 100 h at temperatures up to 750 °C. The adhesion of the printed gold to the ceramic substrates remains high after aging, very stable resistances and minimal leakage currents have been observed.
Ga11y: An Automated GIF Annotation System for Visually Impaired Users (2022)

Animated GIF images have become prevalent in internet culture, often used to express richer and more nuanced meanings than static images. But animated GIFs often lack adequate alternative text descriptions, and it is challenging to generate such descriptions automatically, resulting in inaccessible GIFs for blind or low-vision (BLV) users. To improve the accessibility of animated GIFs for BLV users, we provide a system called Ga11y (pronounced “galley”), for creating GIF annotations. Ga11y combines the power of machine intelligence and crowdsourcing and has three components: an Android client for submitting annotation requests, a backend server and database, and a web interface where volunteers can respond to annotation requests. We evaluated three human annotation interfaces and employ the one that yielded the best annotation quality. We also conducted a multi-stage evaluation with 12 BLV participants from the United States and China, receiving positive feedback.
Online Energy Management Framework for Smart Buildings With Low-Complexity Estimators (2023)

This letter proposes an online energy management framework for smart buildings. Two low-complexity estimators for thermal comfort and electrical load are investigated and integrated into an optimization framework. The proposed framework optimizes operations of a battery system and multiple heating, ventilation, and air conditioning (HVAC) systems to minimize energy consumption and power peak while maximizing occupants’ thermal comfort. The effectiveness of the proposed framework is demonstrated using data measured in actual campus buildings in terms of system costs, thermal comfort, and computational complexity. The results show that the proposed framework can reduce electricity costs by 5.7% compared to the baseline.
Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation (2021)

During the current coronavirus disease 2019 (COVID-19) pandemic, a variety of mutations have accumulated in the viral genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and, at the time of writing, four variants of concern are considered to be potentially hazardous to human society<sup>1</sup>. The recently emerged B.1.617.2/Delta variant of concern is closely associated with the COVID-19 surge that occurred in India in the spring of 2021 (ref. <sup>2</sup>). However, the virological properties of B.1.617.2/Delta remain unclear. Here we show that the B.1.617.2/Delta variant is highly fusogenic and notably more pathogenic than prototypic SARS-CoV-2 in infected hamsters. The P681R mutation in the spike protein, which is highly conserved in this lineage, facilitates cleavage of the spike protein and enhances viral fusogenicity. Moreover, we demonstrate that the P681R-bearing virus exhibits higher pathogenicity compared with its parental virus. Our data suggest that the P681R mutation is a hallmark of the virological phenotype of the B.1.617.2/Delta variant and is associated with enhanced pathogenicity.
Process for enhanced production of desired hydrocarbons from biologically-derived compounds and bio-oils containing cyclic compounds by opening of aromatics and naphthenic ring-containing compounds (2023)

A system and process for processing biologically-derived compounds or a complex bio-oil by converting cyclic compounds in a complex bio-oil or biologically-derived compounds to desired materials such as high molecular weight paraffins with minimal carbon loss by using a ring-contraction catalyst to selectively produce C5 ring containing compounds; and then reacting the C5 ring containing compounds with a C5 ring opening catalyst in a second reactor to minimize carbon loss via cracking reactions.
Approximate circuits for increased reliability (2023)

Embodiments of the invention describe a Boolean circuit having a voter circuit and a plurality of approximate circuits each based, at least in part, on a reference circuit. The approximate circuits are each to generate one or more output signals based on values of received input signals. The voter circuit is to receive the one or more output signals generated by each of the approximate circuits, and is to output one or more signals corresponding to a majority value of the received signals. At least some of the approximate circuits are to generate an output value different than the reference circuit for one or more input signal values; however, for each possible input signal value, the majority values of the one or more output signals generated by the approximate circuits and received by the voter circuit correspond to output signal result values of the reference circuit.
Contrast Agent Ultrasonography before and after HIFU Treatment of Parathyroid Glands (2010)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Roussanka Kovatcheva, Françoise Arnaud, François Lacoste; Contrast Agent Ultrasonography before and after HIFU Treatment of Parathyroid Glands. AIP Conference Proceedings 9 March 2010; 1215 (1): 168–171. https://doi.org/10.1063/1.3367133 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Joint Spectrum and Power Allocation for Multi-node Cooperative Wireless Systems (2014)

Energy efficiency is a growing concern for wireless networks, not only due to the emerging traffic demand from smart devices, but also because of the dependence on the traditional unsustainable energy and the overall environmental concerns. The urgent call for reducing power consumption while meeting system requirements has motivated increasing research efforts on green radio. In this paper, we investigate a new joint spectrum and power allocation scheme for a cooperative downlink multi-user system using the frequency division multiple access scheme, in which arbitrary M base stations (BSs) coordinately allocate their resources to each user equipment (UE). With the assumption that multi-BS UE (user being served by multi-BS) would require the same amount of spectrum from these BSs, we conclude that when the number of multi-BS UEs is limited by M-1, the resource allocation scheme can always guarantee the minimum overall transmit power consumption while meeting the throughput requirement of each UE and also each BS's power constraint. Then, to decide the clusters of multi-BS UEs and the clusters of individual-BS UEs (users being served by individual BSs), we propose a UE-BS association scheme and a complexity reduction scheme. Finally, a novel joint spectrum and power allocation algorithm is proposed to minimize the total power consumption. Simulation results are presented to verify the optimality of the derived schemes.
Bridging parallel and reconfigurable computing with multilevel PGAS and SHMEM+ (2009)

Reconfigurable computing (RC) systems based on FPGAs are becoming an increasingly attractive solution to building parallel systems of the future. Applications targeting such systems have demonstrated superior performance and reduced energy consumption versus their traditional counterparts based on microprocessors. However, most of such work has been limited to small system sizes. Unlike traditional HPC systems, lack of integrated, system-wide, parallel-programming models and languages presents a significant design challenge for creating applications targeting scalable, reconfigurable HPC systems. In this paper, we introduce and investigate a novel programming model based on Partitioned Global Address Space (PGAS), which simplifies development of parallel applications for such systems. The new multilevel PGAS programming model captures the unique characteristics of these systems, such as the existence of multiple levels of memory hierarchy and heterogeneous computation resources. To evaluate this multilevel PGAS model, we extend and adapt the SHMEM programming language to become what we call SHMEM+, the first known SHMEM library enabling coordination between FPGAs and CPUs in a reconfigurable, heterogeneous HPC system. Our design of SHMEM+ is highly portable and provides peak communication bandwidth comparable to vendor-proprietary versions of SHMEM. In addition, applications designed with SHMEM+ yield improved developer productivity compared to current methods of multi-device RC design and achieve a high degree of portability.
Crystal Structure of La4Si2O7N2 Analyzed by the Rietveld Method Using the Time‐of‐Flight Neutron Powder Diffraction Data. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Clinical evaluation of an autofluorescence diagnostic device for oral cancer detection (2012)

The prognosis for patients with oral squamous cell carcinoma remains poor despite advances in multimodal treatment concepts. Early diagnosis and treatment is the key to improved patient survival. A device (VELscope) that uses autofluorescence technology, allowing direct fluorescence visualization of the oral cavity, might be a useful tool for oral cancer detection or as an adjunct to standard clinical examination. A total of 289 patients with oral premalignant lesions were randomly divided into two groups for clinical examination of precancerous oral lesions. In group 1, 166 patients were examined conventionally with white light, and in group 2, 123 patients were examined with the autofluorescence visualization device (VELscope) in addition to the white light examination. Biopsies were obtained from all suspicious areas identified in both examination groups (n=52). In the first step, baseline characteristics of the two groups (only white light vs. white light and VELscope) were compared to exclude selection bias. In the second step, for the group examined with white light and VELscope (123 patients), the diagnostic strategies were compared with regard to sensitivity and specificity using biopsy as the gold standard. The results showed that using the VELscope leads to higher sensitivity (100% instead of 17%), but to lower specificity (74% instead of 97%). Thus, we can conclude that the VELscope is a useful new diagnostic device for detection of oral cancer diseases.
ESI: A proposed European instrument for SPICA (2005)

The proposed JAXA/ISAS SPICA mission will have a cooled 3.5 m dish and will be the next step forward in sensitivity in far infrared astronomy. We describe the scientific case for an imaging Far Infrared Spectrometer for the SPICA mission and the outcome of a conceptual design study carried out by European scientists into the feasibility of such an instrument.
A miniatuirized FBAR duplexer with reduced acoustic loss for the W-CDMA applicaion (2006)

This paper describes the development of a miniaturized antenna duplexer for the W-CDMA application. As the required insertion loss in the W-CDMA system is severe even for the film bulk acoustic resonator (FBAR) technology, we propose a modified FBAR structure, which we called an AlN just-etched FBAR, to reduce acoustic losses. The characteristics of the proposed FBAR are verified by both simulation and experimental data and it is confirmed that the lateral-leakage of acoustic waves is successfully decreased. As results, the Q-factor at the anti-resonance and the effective k 2 are improved from 700 to 900, and 7.4% to 7.5%. The W- CDMA duplexer is designed using the proposed FBAR and integrated lumped elements for the compact and low-loss phase shifters. The insertion losses of the fabricated 3 x 3 mm 2 duplexers are as small as 1.5 dB and 1.6 dB in the Tx and the Rx band with a high isolation.
3,4-Diiodo-2,5-dimethylthiophene (2007)

In the crystal structure of the title compound, C 6 H 6 I 2 S, the molecules pack to form one-dimensional chains connected by intermolecular S...I interactions.
Scalable and high performance monolithic on-chip light sources for integrated silicon photonics (2023)

We report the first electrically pumped InAs quantum dot lasers grown in narrow oxide pockets patterned on 300 mm Si wafer for monolithic on-chip light source. This architecture should enable the next generation of photonics integrated circuit platforms.
Modeling and performance evaluation of improved data formats for optical communications (2004)

Simple on-off keying with intensity modulation using NRZ or RZ-data format is not optimum in the sense of spectral efficiency and robustness towards channel impairments. In this contribution alternative modulation formats are investigated.
Structural strength of cancellous specimens from bovine femur under cyclic compression (2016)

The incidence of osteoporotic fractures was estimated as nine million worldwide in 2000, with particular occurrence at the proximity of joints rich in cancellous bone. Although most of these fractures spontaneously heal, some fractures progressively collapse during the early post-fracture period. Prediction of bone fragility during progressive collapse following initial fracture is clinically important. However, the mechanism of collapse, especially the gradual loss of the height in the cancellous bone region, is not clearly proved. The strength of cancellous bone after yield stress is difficult to predict since structural and mechanical strength cannot be determined a priori. The purpose of this study was to identify whether the baseline structure and volume of cancellous bone contributed to the change in cancellous bone strength under cyclic loading. A total of fifteen cubic cancellous bone specimens were obtained from two 2-year-old bovines and divided into three groups by collection regions: femoral head, neck, and proximal metaphysis. Structural indices of each 5-mm cubic specimen were determined using micro-computed tomography. Specimens were then subjected to five cycles of uniaxial compressive loading at 0.05 mm/min with initial 20 N loading, 0.3 mm displacement, and then unloading to 0.2 mm with 0.1 mm displacement for five successive cycles. Elastic modulus and yield stress of cancellous bone decreased exponentially during five loading cycles. The decrease ratio of yield stress from baseline to fifth cycle was strongly correlated with bone volume fraction (BV/TV, r = 0.96, p < 0.01) and structural model index (SMI, r = - 0.81, p < 0.01). The decrease ratio of elastic modulus from baseline to fifth cycle was also correlated with BV/TV (r = 0.80, p < 0.01) and SMI (r = - 0.78, p < 0.01). These data indicate that structural deterioration of cancellous bone is associated with bone strength after yield stress. This study suggests that baseline cancellous bone structure estimated from adjacent non-fractured bone contributes to the cancellous bone strength during collapse.
Comparing Two Pairing-Based Aggregate Signature Schemes. (2009)

Abstract. In 2003, Boneh, Gentry, Lynn and Shacham (BGLS) devised the first provably-secure aggregate signature scheme. Their scheme uses bilinear pairings and their security proof is in the random oracle model. The first pairing-based aggregate signature scheme which has a security proof that does not make the random oracle assumption was proposed in 2006 by Lu, Ostrovsky, Sahai, Shacham and Waters (LOSSW). In this paper, we compare the security and efficiency of the BGLS and LOSSW schemes when asymmetric pairings derived from Barreto-Naehrig (BN) elliptic curves are employed. 1.
Reagentless cell lysis on a PDMS CD using beads (2004)

Reagentless mechanical cell lysis was demonstrated on a microfluidic CD (Compact Disc) microfabricated in PDMS (Polydimethylsiloxane). The motion of beads in a lysis chamber on the CD causes disruption of mammalian (CHO-K1), bacterial (<i>Escherichia coli</i>), and yeast (<i>Saccharomyces cerevisiae</i>) cells. Interactions between beads and cells are generated in the rimming flow established inside a partially filled annular chamber in the CD rotating around a horizontal axis. To maximize bead-cell interactions, the CD was spun forward and backwards around this axis, using high acceleration for up to 7 minutes. Based on our theoretical work, we investigated the following control parameters: bead density, angular velocity, acceleration rate, and solid volume fraction, all of which influence cell lysis efficiency. Cell disruption efficiency was verified either through direct microscopic viewing or measurement of DNA concentration after cell lysing. Lysis efficiency relative to a conventional lysis protocol was also determined. In the long term, this work is geared towards CD based sample-to-answer nucleic acid analysis which will include cell lysis, DNA purification, DNA amplification, and DNA hybridization detection.
Hanno Millesi: Pioneer of Plastic Surgery and Nerve Surgery (1927–2017) (2020)

Recently, plastic surgery lost one of its most prominent surgeons-Dr. Hanno Millesi. His contributions to the field continue to impact the practice of medicine and surgery. As such, it is appropriate to reflect upon his career and recognize his accomplishments in peripheral nerve surgery, hand surgery, and Dupuytren disease.
Mechanismen der synergistischen Apoptose-Induktion durch die p53-Familienmitglieder p53, p63 und p73 und Chemotherapeutika – neue Therapieoptionen für das hepatozelluläre Karzinom? (2004)

Einleitung: Die p53-Familienmitglieder p63 und p73 weisen nicht nur eine strukturelle Homologie zu p53 auf, sondern können wie p53 Apoptose induzieren. Hinsichtlich der Apoptose-Induktion, insbesondere nach DNA-Schädigung, wird eine Kooperation der p53-Familie vermutet. Wir untersuchen die Interaktion der p53-Familie und deren Bedeutung für das Therapieansprechen beim hepatozellulären Karzinom.