gebhart/patrepeval huggingface dataset:
Condensation of imines with homophthalic anhydrides. A convergent synthesis of cis- and trans-13-methyltetrahydroprotoberberines (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCondensation of imines with homophthalic anhydrides. A convergent synthesis of cis- and trans-13-methyltetrahydroprotoberberinesMark Cushman, John Gentry, and Frederick W. DekowCite this: J. Org. Chem. 1977, 42, 7, 1111–1116Publication Date (Print):April 1, 1977Publication History Published online1 May 2002Published inissue 1 April 1977https://pubs.acs.org/doi/10.1021/jo00427a001https://doi.org/10.1021/jo00427a001research-articleACS PublicationsRequest reuse permissionsArticle Views641Altmetric-Citations114LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Continuous-Mode Inverse Class-GF Power Amplifier With Second-Harmonic Impedance Optimization at Device Input (2021)

In this article, a continuous-mode inverse class GF (CCGF <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> ) power amplifier is introduced based on a new closed-form expression for the drain current. This analytical expression is utilized to exploit second source harmonic impedance manipulation in order to expand the design space of the output matching circuit resistively. This approach allows to diminish the complexity of the design of the load matching network at the fundamental and harmonic frequencies and to achieve wider bandwidth while simultaneously improving drain efficiency across the new optimum admittance points. Using the nonlinear model of a commercially available 10-W gallium nitride (GaN) device, load-pull and source-pull techniques are used to design a wideband CCGF <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> . The designed amplifier is fabricated using the selected transistor in low-temperature co-fired ceramic (LTCC) technology. Measurement results show that, over the frequency band between 3.05 and 3.85 GHz, a drain efficiency of more than 70%, 11-12.4-dB gain, and 39.9-41.4-dBm output power at 3-dB gain compression have been achieved. Although not designed for linearity, the fabricated amplifier shows an adjacent channel power ratio better than 26 dBc under a 20-MHz long-term evolution (LTE) signal having a 10.45-dB peak-to-average power ratio.
HIV-1 rational vaccine design: molecular details of b12–gp120 complex structure (2007)

Evaluation of: Zhou T, Xu L, Dey B et al. Structural definition of a conserved neutralizing epitope on HIV-1 gp120. Nature 445(7129), 732–737 (2007).One of the great challenges for the design of an effective HIV-1 vaccine is the design of an immunogen that will evoke neutralizing antibody responses to a broad spectrum of the different HIV isolates now circulating. Unlike the current vaccines that were invented mostly by trial and error, HIV-1, to date, has resisted all such empirical efforts and, thus, a rational vaccine design approach is necessary. To evoke an effective virus-neutralizing immune response to HIV-1, one logical target to consider is the site of viral attachment to the cellular receptor. The paper under evaluation has advanced the feasibility of this approach by solving the high resolution crystal structure of the envelope protein, gp120, bound to a broadly neutralizing monoclonal antibody, b12, that recognizes the CD4-binding site. Zhou and colleagues’ work provides a ‘molecular map’ of this domain to accelerate a rational immunogen-design effort with the potential to offer a host of novel vaccine candidates for evaluation.
Development of an in vitro model of contraction by fibroblasts (2001)

Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2001.
Evaluating and improving local hyperspectral anomaly detectors (2024)

Abstract Not Provided
Thermally Balanced Writing for High-Speed Compact Disc Recordable (CD-R) Recording (2002)

A thermally balanced write strategy has been developed for high-speed recording of CD-recordable (CD-R). It is adopted in the recent multi-speed CD-R standard as the media testing condition. The write strategy accounts for the effects of thermal interference and heat accumulation during the recording process. Detailed thermal calculations of the resulting pit shapes and sizes support the approach. CD-R recording speeds of up to 40X are demonstrated using this Thermally Balanced Write Strategy.
Exploring Graphene Effect on Fiber Optic Surface Plasmon Resonance Biosensor (2019)

This report investigates design enhancements of Fiber Optic Surface Plasmon Resonance (FO-SPR) biosensors with Gold and Silver metallic films. The effect of adding a Graphene coating on the sensitivity and detection accuracy of FO-SPR biosensors is studied. We also compare the results for the addition of five layers of Graphene on both Gold-based and Silver-based FO-SPR biosensors in order to determine the optimum sensor design. Our results indicate that the sensitivity of the biosensor increases when a Graphene coating is added, while the detection accuracy decreases. Results also demonstrate that the sensitivity due to adding Graphene sheets increases more for Silver-based biosensor when compared to Gold-based biosensors.
Approximating the LLR Distribution for a Class of Soft-Output MIMO Detectors (2012)

We present approximations of the LLR distribution for a class of fixed-complexity soft-output MIMO detectors, such as the optimal soft detector and the soft-output via partial marginalization detector. More specifically, in a MIMO AWGN setting, we approximate the LLR distribution conditioned on the transmitted signal and the channel matrix with a Gaussian mixture model (GMM). Our main results consist of an analytical expression of the GMM model (including the number of modes and their corresponding parameters) and a proof that, in the limit of high SNR, this LLR distribution converges in probability towards a unique Gaussian distribution.
Sleep health of young adults in Western Australia and associations with physical and mental health: A population-level cross-sectional study (2023)

Findings could inform public health interventions, including screening guidelines, to improve the sleep health and, in turn, the physical and mental health of young adults in Australia.
Highly Responsive Plasmon Modulation in Dopant-Segregated Nanocrystals (2023)

Electron transfer to and from metal oxide nanocrystals (NCs) modulates their infrared localized surface plasmon resonance (LSPR), revealing fundamental aspects of their photophysics and enabling dynamic optical applications. We synthesized and chemically reduced dopant-segregated Sn-doped In<sub>2</sub>O<sub>3</sub> NCs, investigating the influence of radial dopant segregation on LSPR modulation and near-field enhancement (NFE). We found that core-doped NCs show large LSPR shifts and NFE change during chemical titration, enabling broadband modulation in LSPR energy of over 1000 cm<sup>-1</sup> and of peak extinction over 300%. Simulations reveal that the evolution of the LSPR spectra during chemical reduction results from raising the surface Fermi level and increasing the donor defect density in the shell region. These results establish dopant segregation as a useful strategy to engineer the dynamic optical modulation in plasmonic semiconductor NC heterostructures going beyond what is possible with conventional plasmonic metals.
Microtubule and microfilament dynamics in porcine oocytes during meiotic maturation (1996)

Microtubule and microfilament organization in porcine oocytes during maturation in vivo and in vitro was imaged by immunocytochemistry and laser scanning confocal microscopy. At the germinal vesicle stage, microtubules were not detected in the oocyte. After germinal vesicle breakdown, a small microtubule aster was observed near the condensed chromatin. During the prometaphase stage, microtubule asters were found in association with each chromatin mass. The asters then elongated and encompassed the chromatin at the metaphase-I stage. At anaphase-I and telophase-I microtubules were detected in the meiotic spindle. Microtubules were observed only in the second meiotic spindle at the metaphase-II stage. The meiotic spindle was a symmetric, barrel-shaped structure containing anastral broad poles, located peripherally and radially oriented. Taxol, a microtubule-stabilizing agent, did not induce microtubules in oocytes at the germinal vesicle stage. After germinal vesicle breakdown, numerous cytoplasmic foci of microtubules were formed in the entire oocyte when oocytes were incubated in the presence of taxol. Microfilaments were observed as a relatively thick uniform area around the cell cortex and were also found throughout the cytoplasm of oocytes at the germinal vesicle stage. After germinal vesicle breakdown, the microfilaments were concentrated close to the female chromatin. During prometaphase, microfilaments were chromatin moved to the peripheral position. At metaphase-I, two domains, a thick and a thin microfilament area, existed in the egg cortex. Chromosomes were located in the thick microfilament domain of the cortex. In summary, these results suggest that both microtubules and microfilaments are closely involved with chromosomal dynamics after germinal vesicle breakdown and during meiotic maturation in porcine oocytes.
Improved maximum likelihood frequency offset estimation based on likelihood metric design (2006)

For emerging high data-rate communication systems in highly dispersive channels such as ultrawideband (UWB) systems, possible frequency offsets could be larger than the estimation range of the existing methods using training signals with identical parts or repetitive training signals (i.e., the training signals are composed of several identical subblocks or are obtained by repeating a training subblock for several times). This paper presents a novel improved maximum likelihood frequency offset estimator which can handle at least twice the estimation range of the existing methods using training signals with identical parts and achieves a better estimation performance. Based on the likelihood metric, a new design metric is introduced which is a pair-wise error probability (PEP) between the correct frequency offset point and a trial frequency offset point. The proposed PEP metric gives more theoretical insights on the performance of practical maximum likelihood estimators. How to design the PEP to achieve both a larger estimation range and a better estimation performance in fading channel environments is also presented and the corresponding estimator implementation is described.
Economic analysis of celecoxib versus diclofenac plus omeprazole for the treatment of arthritis in patients at risk of ulcer disease (2003)

Celecoxib therapy appears to cost less compared with diclofenac plus omeprazole for treatment of arthritis in Chinese patients with a high risk of bleeding.
Cancer Vulnerabilities Unveiled by Genomic Loss (2012)

Due to genome instability, most cancers exhibit loss of regions containing tumor suppressor genes and collateral loss of other genes. To identify cancerspecific vulnerabilities that are the result of copy number losses, we performed integrated analyses of genome-wide copy number and RNAi profiles and identified 56 genes for which gene suppression specifically inhibited the proliferation of cells harboring partial copy number loss of that gene. These CYCLOPS (copy number alterations yielding cancer liabilities owing to partial loss) genes are enriched for spliceosome, proteasome, and ribosome components. One CYCLOPS gene, PSMC2, encodes an essential member of the 19S proteasome. Normal cells express excess PSMC2, which resides in a
Identification of protective and broadly conserved vaccine antigens from the genome of extraintestinal pathogenic Escherichia coli (2010)

Extraintestinal pathogenic Escherichia coli (ExPEC) are a common cause of disease in both mammals and birds. A vaccine to prevent such infections would be desirable given the increasing antibiotic resistance of these bacteria. We have determined the genome sequence of ExPEC IHE3034 (ST95) isolated from a case of neonatal meningitis and compared this to available genome sequences of other ExPEC strains and a few nonpathogenic E. coli. We found 19 genomic islands present in the genome of IHE3034, which are absent in the nonpathogenic E. coli isolates. By using subtractive reverse vaccinology we identified 230 antigens present in ExPEC but absent (or present with low similarity) in nonpathogenic strains. Nine antigens were protective in a mouse challenge model. Some of them were also present in other pathogenic non-ExPEC strains, suggesting that a broadly protective E. coli vaccine may be possible. The gene encoding the most protective antigen was detected in most of the E. coli isolates, highly conserved in sequence and found to be exported by a type II secretion system which seems to be nonfunctional in nonpathogenic strains.
Adaptive layered coding based energy efficient multicast transmission scheme over wireless access networks (2014)

In this paper, we consider both 1) an non-layered coding and 2) a layered coding based (i.e., scalable video coding based) multicast transmission. Specifically, the non-layered coding based multicast transmission guarantees fair services over all users in multicast group (MGroup), however it might require much power consumption to support the fair service of the worst channel condition user. On the other hands, the layered coding based multicast transmission has a chance to reduce the transmission power since each user receives different quality of services according to its channel condition. For instance, the worst channel user only needs to receive a minimum quality of service with low data rate. Therefore, through this difference from two approaches, we first provide a rigorous analysis about how these two schemes impact on the multicast energy efficiency according to various parameters (e.g., the number of users in MGroup, cell coverage etc). Furthermore, we present the novel hybrid approach, which adaptively selects between the non-layered coding and layered coding based multicast according to multicast energy efficiency. Detailed numerical results are provided to illustrate the effectiveness of our proposed scheme. This novel energy related study for multicast transmission provides an important insight for energy efficient multicast transmission design in the future transmission technologies.
Electro-optic Sampling of Mid-to-Near-Infrared Waveforms (2015)

Electro-optic sampling is a valuable tool in the terahertz range for sensitive, time-resolved electric field measurement. We show that this technique can be extended to the near infrared for unambiguous measurement of broadband, phase-locked pulses.
Continuous Saccharification of Corn Starch in a Membrane Reactor. Part II: Membrane Performance and Reactor Stability (1992)

Abstract Fouling of the hollow‐fiber ultrafiltration membrane was not significant. However, there was a considerable difference in the steady‐state permeate flux for each of the solutions studied. The feed solution containing 300 g/L glucose and 33 g/L liquefied starch resulted in the lowest steady‐state flux of 1.48L/m 2 /h (LMH). Performance of the membrane as a function of transmembrane pressure, and flow rate was also evaluated. At a given transmembrane pressure, flow rate had no effect on permeate flux indicating that the membrane module was operating in the pressure controlled region. Concentration polarization effects were also minimal at the operating conditions studied. At the enzyme concentrations employed in these studies, loss of enzyme activity due to membrane leakage, mechanical shear, thermal inactivation and/or membrane “poisoning” had little effect on reactor stability and glucose production.
Butyrate Differentiates Permissiveness to Clostridioides difficile Infection and Influences Growth of Diverse C. difficile Isolates (2023)

A disrupted "dysbiotic" gut microbiome engenders susceptibility to the diarrheal pathogen Clostridioides difficile by impacting the metabolic milieu of the gut. Diet, in particular the microbiota-accessible carbohydrates (MACs) found in dietary fiber, is one of the most powerful ways to affect the composition and metabolic output of the gut microbiome. As such, diet is a powerful tool for understanding the biology of C. difficile and for developing alternative approaches for coping with this pathogen. One prominent class of metabolites produced by the gut microbiome is short-chain fatty acids (SCFAs), the major metabolic end products of MAC metabolism. SCFAs are known to decrease the fitness of C. difficile <i>in vitro</i>, and high intestinal SCFA concentrations are associated with reduced fitness of C. difficile in animal models of C. difficile infection (CDI). Here, we use controlled dietary conditions (8 diets that differ only by MAC composition) to show that C. difficile fitness is most consistently impacted by butyrate, rather than the other two prominent SCFAs (acetate and propionate), during murine model CDI. We similarly show that butyrate concentrations are lower in fecal samples from humans with CDI than in those from healthy controls. Finally, we demonstrate that butyrate impacts growth in diverse C. difficile isolates. These findings provide a foundation for future work which will dissect how butyrate directly impacts C. difficile fitness and will lead to the development of diverse approaches distinct from antibiotics or fecal transplant, such as dietary interventions, for mitigating CDI in at-risk human populations. <b>IMPORTANCE</b> Clostridioides difficile is a leading cause of infectious diarrhea in humans, and it imposes a tremendous burden on the health care system. Current treatments for C. difficile infection (CDI) include antibiotics and fecal microbiota transplant, which contribute to recurrent CDIs and face major regulatory hurdles, respectively. Therefore, there is an ongoing need to develop new ways to cope with CDI. Notably, a disrupted "dysbiotic" gut microbiota is the primary risk factor for CDI, but we incompletely understand how a healthy microbiota resists CDI. Here, we show that a specific molecule produced by the gut microbiota, butyrate, is negatively associated with C. difficile burdens in humans and in a mouse model of CDI and that butyrate impedes the growth of diverse C. difficile strains in pure culture. These findings help to build a foundation for designing alternative, possibly diet-based, strategies for mitigating CDI in humans.
ChemInform Abstract: THE EFFECT OF LEWIS ACID AND SOLVENT ON CONCERTED 1,2‐ACYL MIGRATION (1985)

Abstract Die durch Lewissäuren katalysierte 1,2‐Benzoylwanderung in den E‐ bzw. Z‐Dypnonoxiden (I) ist ein konzertierter Vorgang, der in nicht polaren Lösungsmitteln unter Inversion der Konfiguration erfolgt.
Rose bengal ethyl ester aggregation in aqueous solution (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRose bengal ethyl ester aggregation in aqueous solutionOscar Valdes-Aguilera and D. C. NeckersCite this: J. Phys. Chem. 1988, 92, 15, 4286–4289Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://pubs.acs.org/doi/10.1021/j100326a010https://doi.org/10.1021/j100326a010research-articleACS PublicationsRequest reuse permissionsArticle Views342Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts