gebhart/patrepeval huggingface dataset:
Personalized blood flow computations: A hierarchical parameter estimation framework for tuning boundary conditions (2016)

We propose a hierarchical parameter estimation framework for performing patient-specific hemodynamic computations in arterial models, which use structured tree boundary conditions. A calibration problem is formulated at each stage of the hierarchical framework, which seeks the fixed point solution of a nonlinear system of equations. Common hemodynamic properties, like resistance and compliance, are estimated at the first stage in order to match the objectives given by clinical measurements of pressure and/or flow rate. The second stage estimates the parameters of the structured trees so as to match the values of the hemodynamic properties determined at the first stage. A key feature of the proposed method is that to ensure a large range of variation, two different structured tree parameters are personalized for each hemodynamic property. First, the second stage of the parameter estimation framework is evaluated based on the properties of the outlet boundary conditions in a full body arterial model: the calibration method converges for all structured trees in less than 10 iterations. Next, the proposed framework is successfully evaluated on a patient-specific aortic model with coarctation: only six iterations are required for the computational model to be in close agreement with the clinical measurements used as objectives, and overall, there is a good agreement between the measured and computed quantities. Copyright © 2016 John Wiley & Sons, Ltd.
Physically realizing an optimized sparse spectrum via joint design of a collection of FM waveforms (2018)

Within a Marginal Fisher's Information (MFI) framework, the design of disjoint coherent frequency allocations is examined for the purpose of spectrum sharing. While the overall bandwidth establishes the radar range resolution, it is possible to reallocate a portion of this bandwidth to other users for a trade-off in terms of increased range sidelobes. For a given percent allocation for radar usage, MFI is used to search for advantageous disjoint frequency distributions from the standpoint of minimizing sidelobe degradation, along with an imperative to maintain spectral cohesion to the degree possible (i.e. keep the number of contiguous bands to a minimum). It is then demonstrated that individual polyphase-coded FM (PCFM) waveforms can be associated with these bands to optimize the collective radar emission jointly.
Optical reliability of cladding pump fiber for high power communication networks (2003)

High power lasers and amplifiers for communication networks based on cladding pump fiber operate at unprecedented power levels. The high power and unique structure of cladding pump fiber present new challenges to the optical reliability of lasers and amplifiers based on these novel fibers. In this paper we present results on the reliability of cladding pump fiber under high power both in the multimode pump waveguide and in the rare earth doped core.
Cerebral organization for language in deaf and hearing subjects: Biological constraints and effects of experience (1998)

Cerebral organization during sentence processing in English and in American Sign Language (ASL) was characterized by employing functional magnetic resonance imaging (fMRI) at 4 T. Effects of deafness, age of language acquisition, and bilingualism were assessed by comparing results from (i) normally hearing, monolingual, native speakers of English, (ii) congenitally, genetically deaf, native signers of ASL who learned English late and through the visual modality, and (iii) normally hearing bilinguals who were native signers of ASL and speakers of English. All groups, hearing and deaf, processing their native language, English or ASL, displayed strong and repeated activation within classical language areas of the left hemisphere. Deaf subjects reading English did not display activation in these regions. These results suggest that the early acquisition of a natural language is important in the expression of the strong bias for these areas to mediate language, independently of the form of the language. In addition, native signers, hearing and deaf, displayed extensive activation of homologous areas within the right hemisphere, indicating that the specific processing requirements of the language also in part determine the organization of the language systems of the brain.
Reconfigurable RF Circuits for Future Band-Free Mobile Terminals (2007)

Reconfigurable radio frequency (RF) circuits will be the predominant solution for future global and compact mobile terminals. Recent progress in RF-microelectromechanical systems (MEMS) devices has bolstered the hope for the implementation of high-performance reconfigurable RF circuits. This paper presents configurations for a novel band-reconfigurable power amplifier, a reconfigurable isolator, and a center frequency and bandwidth tunable filter. These RF circuits were prototyped. The reconfigurable power amplifier using MEMS switches achieves comparable performance to that of a single-band power amplifier in four different frequency bands. The isolator and the filter prototypes confirm the feasibility of the proposed configuration. These reconfigurable RF circuits will contribute to band-free operation in future mobile terminals.
Study of Renewable Energy Penetration on a Benchmark Generation and Transmission System (2020)

Significant changes in conventional generator operation and transmission system planning will be required to accommodate increasing solar photovoltaic (PV) penetration. There is a limit to the maximum amount of solar that can be connected in a service area without the need for significant upgrades to the existing generation and transmission infrastructure. This study proposes a framework for analyzing the impact of increasing solar penetration on generation and transmission networks while considering the responses of conventional generators to changes in solar PV output power. Contrary to traditional approaches in which it is assumed that generation can always match demand, this framework employs a detailed minute-to-minute (M-M) dispatch model capable of capturing the impact of renewable intermittency and estimating the over- and under-generation dispatch scenarios due to solar volatility and surplus generation. The impact of high solar PV penetration was evaluated on a modified benchmark model, which includes generators with defined characteristics including unit ramp rates, heat rates, operation cost curves, and minimum and maximum generation limits. The PV hosting capacity, defined as the maximum solar PV penetration the system can support without substantial generation imbalances, transmission bus voltage, or thermal violation was estimated for the example transmission circuit considered. The results of the study indicate that increasing solar penetration may lead to a substantial increase in generation imbalances and the maximum solar PV system that can be connected to a transmission circuit varies based on the point of interconnection, load, and the connected generator specifications and responses.
Neto1 Is a Novel CUB-Domain NMDA Receptor–Interacting Protein Required for Synaptic Plasticity and Learning (2009)

The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic plasticity. Here we report that neuropilin tolloid-like 1 (Neto1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density. Neto1-null mice have depressed long-term potentiation (LTP) at Schaffer collateral-CA1 synapses, with the subunit dependency of LTP induction switching from the normal predominance of NR2A- to NR2B-NMDARs. NMDAR-dependent spatial learning and memory is depressed in Neto1-null mice, indicating that Neto1 regulates NMDA receptor-dependent synaptic plasticity and cognition. Remarkably, we also found that the deficits in LTP, learning, and memory in Neto1-null mice were rescued by the ampakine CX546 at doses without effect in wild-type. Together, our results establish the principle that auxiliary proteins are required for the normal abundance of NMDAR subunits at synapses, and demonstrate that an inherited learning defect can be rescued pharmacologically, a finding with therapeutic implications for humans.
Full‐duplex Radios (2016)

This chapter presents the design and implementation of the first in-band full-duplex WiFi radios that can simultaneously transmit and receive on the same channel using standard WiFi 802.11 ac PHYs and achieves close to the theoretical doubling of throughput in all practical deployment scenarios. Our design uses a single antenna for simultaneous TX/RX (the same resources as a standard half-duplex system). We also propose novel analog and digital cancellation techniques that remove the self-interference to the receiver noise floor, and therefore ensure that there is no degradation to the received signal. We prototype our design by building our own analog circuit boards and integrating them with a fully WiFi–PHY compatible software radio implementation. We show experimentally that our design works robustly in noisy indoor environments, and provides close to the expected theoretical doubling of throughput in practice.
A new calibration method for mixer delay measurements that requires no calibration mixer (2011)

Making phase and group delay response measurements on mixers and frequency converters has traditionally been a difficult and complicated process, requiring either modulated-signals (and demodulation), two-tone signals (a special form of modulation) or a system with a reference or reconverting mixer and a calibration or “golden” mixer. This paper presents a method to measure the phase response of a mixer on a VNA calibrating the input and output phase response independently, computing the transfer response directly using a phase reference, and is traceable to national standards. This method, for the first time, eliminates the need for any other mixer, reference or calibration, in the test system.
Faculty Opinions recommendation of Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. (2003)

Read the full review for this Faculty Opinions recommended article: Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity.
Audiology for the Neurosurgeon (2023)

Many conditions that neurosurgeons manage are associated with audiologic symptoms. Unilateral hearing loss and tinnitus, poor suprathreshold speech understanding, and dizziness are hallmarks of retrocochlear lesions. Understanding the difference between air and bone conduction thresholds and the importance of speech discrimination helps differentiate types of hearing loss and their neurological importance. Acoustic reflex, otoacoustic emissions, and auditory brainstem response testing are objective measures used to determine function of the auditory structures. Accurate interpretation of these results can aid neurosurgeons in making differential diagnoses and determining surgical approaches. Cooperation among neurosurgeons, otolaryngologists, and audiologists ensures abnormal auditory symptoms are assessed correctly.
Data from Transformation-Dependent Silencing of Tumor-Selective Apoptosis-Inducing TRAIL by DNA Hypermethylation Is Antagonized by Decitabine (2023)

&lt;div&gt;Abstract&lt;p&gt;TNF-related apoptosis-inducing ligand (TRAIL) kills tumor cells selectively. We asked how emerging tumor cells escape elimination by TRAIL and how tumor-specific killing by TRAIL could then be restored. We found that TRAIL expression is consistently downregulated in HRAS&lt;sub&gt;G12V&lt;/sub&gt;-transformed cells in stepwise tumorigenesis models derived from four different tissues due to DNA hypermethylation of CpG clusters within the &lt;i&gt;TRAIL&lt;/i&gt; promoter. Decitabine de-silenced &lt;i&gt;TRAIL&lt;/i&gt;, which remained inducible by interferon, while induction of TRAIL by blocking the HRAS&lt;sub&gt;G12V&lt;/sub&gt;-activated mitogen-activated protein kinase pathway was subordinated to epigenetic silencing. Decitabine induced apoptosis through upregulation of endogenous TRAIL in cooperation with favorable regulation of key players acting in TRAIL-mediated apoptosis. Apoptosis induction by exogenously added TRAIL was largely increased by decitabine. &lt;i&gt;In vivo&lt;/i&gt; treatment of xenografted human HRAS&lt;sub&gt;G12V&lt;/sub&gt;-transformed human epithelial kidney or syngenic mice tumors by decitabine blocked tumor growth induced TRAIL expression and apoptosis. Our results emphasize the potential of decitabine to enhance TRAIL-induced apoptosis in tumors and thus provide a rationale for combination therapies with decitabine to increase tumor-selective apoptosis. &lt;i&gt;Mol Cancer Ther; 10(9); 1611–23. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Cationic polymerization of aliphatic olefins: Highlights of latest developments at the university of akron (1974)

Abstract The cationic copolymerization of isobutylene and β‐pinene (2(10)‐pinene) yields random copolymers which exhibit interesting physical properties. E.g. , high molecular weight copolymers containing isobutylene/β‐pinene in the ratio of 90/10 and 97/3 are sulfur‐vulcanizable ozone‐resistant elastomers. Copolymer synthesis was accomplished with Friedel‐Crafts halides e.g. , C 2 H 5 AlCl 2 , BF 3 , etc. using ethyl chloride diluent at low temperatures. The structure of the copolymers was determined by NMR spectroscopy. The reactivity ratios of isobutylene and β‐pinene are stongly affected by temperature, however, are much less sensitive to the particular Lewis acid used. Interestingly, with C 2 H 5 AlCl 2 , the individual reactivity ratios become equal to unity below ca. −100°C, i.e. , the copolymerization becomes azeotropic. The mechanism of cationic olefin polymerizations induced by various alkylaluminum compounds has been investigated by model reactions. The rate of the reactions. The rate of the reaction equation image is strongly affected by the nature of the (CH 3 ) 3 CX and the CH 3 X solvent (X=Cl, Br. I). Unexpectedly, the sequence of rates of this reaction was found to be (CH 3 ) 3 CCl&gt;(CH 3 ) 3 CBr&gt;(CH 3 ) 3 Cl. Further, an intensive study of the 2,4,4‐trimethyl‐1‐pentene/(CH 3 ) 3 Al/(CH 3 ) 3 CCl model system gave a series of important mechanistic insights. E.g. , if an alkylaluminum compound having a β‐hydrogen in respect to aluminum is used as the coinitiator e.g. , (C 2 H 5 ) 3 Al, [(CH 3 ) 2 CHCH 2 ] 3 Al, etc. , rapid hydridation terminates the reaction:
The Last Mile (2014)

The National Institute of Diabetes and Digestive and Kidney Diseases-supported Kidney Research National Dialogue asked the scientific community to formulate and prioritize research objectives that would enhance understanding of kidney function and disease and improve clinical outcomes. An engaged and growing group of investigators working in type 2 translation (from clinical evidence to implementation in the community) identified barriers to improving patient care in CKD and suggested research priorities to test translational strategies that have been effective for other chronic diseases.
Simple bit-rate-independent PMD monitoring for WDM systems (2002)

We propose a simple bit-rate-independent PMD (polarization mode dispersion) monitoring scheme for WDM systems that uses two polarization scramblers and a PDL (polarization-dependent-loss) component. We monitor the instantaneous DGD (differential group delay) for NRZ (non RZ) and RZ (return-to-zero) formats, and use the monitor output as a feedback for PMD compensation of a 10 Gbit/s NRZ channel.
In-Situ Characterization of Lithium Ion Batteries in the SEM (2022)

This paper will present state of the art characterization of Lithium Ion Batteries usimg low voltage EELS and EDS of Li using the SU-9000 STEM from Hitachi working at 30 keV and 3 keV. Extensive in-situ work in SEM of LIB made with Li anodes will also be presented.
3D-QSAR of angiotensin-converting enzyme and thermolysin inhibitors: a comparison of CoMFA models based on deduced and experimentally determined active site geometries (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT3D-QSAR of angiotensin-converting enzyme and thermolysin inhibitors: a comparison of CoMFA models based on deduced and experimentally determined active site geometriesScott A. DePriest, Dorica Mayer, Christopher B. Naylor, and Garland R. MarshallCite this: J. Am. Chem. Soc. 1993, 115, 13, 5372–5384Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/ja00066a004https://doi.org/10.1021/ja00066a004research-articleACS PublicationsRequest reuse permissionsArticle Views559Altmetric-Citations139LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (4)»Supporting Information Supporting Information Get e-Alerts
High accuracy frequency domain immersion technique (2003)

Summary form only given. For an intensity modulated source, light propagation in turbid media can be described by diffuse photon density waves. Through measuring these waves, the optical properties of the medium can be determined. In the near infrared photon migration in tissue is described by diffusion, since scattering dominates absorption. In this paper we show that the optical properties of a small (ca. 1 cm thick) object can be measured with an absolute accuracy of 5% by immersion into a known reference medium. This high accuracy could be a step towards non-invasive tissue spectroscopy without the necessity of performing a spatial scan.
Supplemental Figure 2 from The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer (2023)

&lt;p&gt;Supplemental Figure 2. FRS2 suppression induces apoptosis in FRS2 amplified cell lines, shown by propidium iodide staining and flow cytometry.&lt;/p&gt;
On the Performance of IDMA-Based Non-Orthogonal Multiple Access Schemes (2017)

Non-orthogonal multiple access (NOMA) is an important part of the emerging fifth generation (5G) of mobile communications systems. NOMA schemes based on a long spreading mechanism, such as interleave division multiple access (IDMA), are among the main candidates for potential use in 5G. Interleave-based NOMA methods can provide a robust performance in highly interfered environments. In this paper, we present our performance evaluation results for IDMA and its simplified variants, namely, resource spreading multiple access (RSMA) and RSMA with interference cancellation (RSMA-SIC). In our evaluation, various interference scenarios, fading conditions and channel estimation errors are considered. Our results indicate that while IDMA offers the best performance, RSMA and RSMA-SIC may also maintain a respectable level of performance with a lower complexity.
New Strategies for High Resolution Photoresists. (2002)

2-[4-(2-hydroxyhexafluoro isopropyl)cyclohexane]hexafluoroisopropyl acrylate (AF) was prepared as a key monomer for 157nm photoresist platforms. In order to balance transparency with other desirable traits such as etch resistance, new strategies for high resolution photoresists were developed and are discussed. (1) The α-trifluoromethyl group was introduced on the polymer backbone and the resulting polymer showed unexpectedly high transparency at 157nm (A=1.6μm-1) despite a carbonyl group in all the monomers. A new 157nm transparent monomer that will provide a solubility switch necessary for base solubility was designed. (2) p-t-Butoxy-tetrafluorostyrene was copolymerized with AF. The high acidity of p-hydroxy-tetrafluorostyrene allowed us to increase the content of the monomer in the system to produce a novel polymer that is highly transparent at 157nm (A=2.1μm-1). The polymer showed good 248nm lithographic performances. (3) Introduction of fluorine on the polymer backbone was carried out. Due to a lower electron density of the vinyl groups with fluorine, these vinyl monomers can be copolymerized with electron-rich vinyl monomers such as norbornene using radical initiators. 2-Methyl-2-adamantyl trifluoroacrylate (MAdTFA) was synthesized. An alternating copolymer with a norbornene derivative was found to have high Tg and gave clear images using 248nm imaging.
Numerical Study of Current-Induced Domain-Wall Dynamics: Crossover from Spin Transfer to Momentum Transfer (2009)

We study current-induced dynamics of a magnetic domain wall by solving a time-dependent Schr\"{o}dinger equation combined with Landau-Lifshitz-Gilbert equation in a one-dimensional electron system coupled to localized spins. Two types of domain-wall motions are observed depending on the hard-axis anisotropy, $K_{\perp}$, of the localized spin system. For small values of $K_{\perp}$, the magnetic domain wall shows a streaming motion driven by spin transfer. In contrast, for large values of $K_{\perp}$, a stick-slip motion driven by momentum transfer is obtained. We clarify the origin of these characters of domain-wall motions in terms of the dynamics of one-particle energy levels and distribution functions.
Commentary on ATX-101 (Deoxycholic Acid Injection) Treatment in Men (2017)

Department of Medicine (Dermatology), David Geffen School of Medicine, University of California, Los Angeles, California Department of Dermatology, University of California, Irvine, California Private Practice, Newport Beach, California Cornell University Ithaca, New York Adam M. Rotunda, MD, receives royalty from sales of deoxycholic acid. The remaining author has indicated no significant interest with commercial supporters.