gebhart/patrepeval huggingface dataset:
Placental Chorionic Cyst Fluid Has Prothrombotic Properties and Differs From Amniotic Fluid (2019)

Our data provide the first evidence that chorionic cyst fluid is prothrombotic and different from amniotic fluid. The association of ruptured cysts with adjacent thrombi and the prothrombotic properties of cyst fluid suggest a causal relationship; however, further studies are needed.
Multi-Switch for Antenna Selection in Massive MIMO (2014)

Massive MIMO has been shown to greatly improve spectral and transmit-energy efficiency. When implementing a massive MIMO system, one challenge is high hardware complexity. A solution is to reduce the number of radio frequency (RF) transceiver chains by performing antenna selection. However, a full RF switch that connects the antennas and RF chains can be highly complex and incurs significant loss in output signal quality, especially when the number of antennas and RF chains are large. We therefore propose a simpler solution - binary switching architecture, which is suboptimal but provides better signal quality, as compared to the full switching network. To evaluate the proposed technique, we compare the sum-rate capacity when using several different configurations of binary switching with the performance of the full switching. Full MIMO performance obtained without antenna selection is also presented as a reference. The investigations in this paper are all based on measured channel data at 2.6 GHz, using a uniform linear array and a cylindrical array, both having 128 antenna elements. It is found that the proposed binary switching gives very competitive performance that are close to the full switching, for the measured channels. The results indicate a potential to simplify massive MIMO hardware by reducing the number of RF chains, and performing antenna selection with simple binary switching architecture.
The pre-myopic syndrome (1995)

Considering the social importance of myopia in industrialised countries, this study aimed to research criteria which could determine whether a person might become myopic. For this purpose, a sample of 25 emmetropic (plano to +0.75 D) subjects, who became myopic during the 2 years following the initial eye examination (the pre-myopic group), were compared to a matched sample of subjects who did not become myopic during the same period. The results show at the 95% statistical level of confidence, that the pre-myopes have particular characteristics, such as a loss of physiological hyperopia, a more positive near retinoscopy and near cross-cylinders and tendency to esophoria. The test of dioptric variations* points to a decrease in the dynamics of accommodation as well as non-overlapping of near and far comfort zones.
Correction of Valgus Knee Deformity with a Supracondylar V Osteotomy (1987)

Valgus deformities at the knee can be successfully corrected with V-shaped supracondylar osteotomy. The advantages of this relatively simple technique are low morbidity, good stability with early weight-bearing, no need for internal fixation, and ability to adjust alignment with postoperative cast. Healing is relatively rapid (two months), and the range of motion returns (two months after cast removal) to preoperative values. This technique proved useful for deformities in both young and old patients with osteoarthritis. This is a preliminary report of the surgical technique, postoperative management, and short-term results of a prospectively evaluated series of 14 consecutive cases.
High-throughput single-cell image analysis of living Euglena gracilis for efficient biofuel production (2016)

We demonstrate label-free single-cell image cytometry of Euglena gracilis, a lipid-producing microalga, with a high throughput of 15,000 cells/s for evaluating and optimizing its lipid production efficiency.
Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation (2013)

Pulsatile release of hypothalamic gonadotropin-releasing hormone (GnRH) is essential for pituitary gonadotrope function. Although the importance of pulsatile GnRH secretion has been recognized for several decades, the mechanisms underlying GnRH pulse generation in hypothalamic neural networks remain elusive. Here, we demonstrate the ultradian rhythm of GnRH gene transcription in single GnRH neurons using cultured hypothalamic slices prepared from transgenic mice expressing a GnRH promoter-driven destabilized luciferase reporter. Although GnRH promoter activity in each GnRH neuron exhibited an ultradian pattern of oscillations with a period of ∼10 h, GnRH neuronal cultures exhibited partially synchronized bursts of GnRH transcriptional activity at ∼2-h intervals. Surprisingly, pulsatile administration of kisspeptin, a potent GnRH secretagogue, evoked dramatic synchronous activation of GnRH gene transcription with robust stimulation of pulsatile GnRH secretion. We also addressed the issue of hierarchical interaction between the circadian and ultradian rhythms by using Bmal1-deficient mice with defective circadian clocks. The circadian molecular oscillator barely affected basal ultradian oscillation of GnRH transcription but was heavily involved in kisspeptin-evoked responses of GnRH neurons. In conclusion, we have clearly shown synchronous bursts of GnRH gene transcription in the hypothalamic GnRH neuronal population in association with episodic neurohormone secretion, thereby providing insight into GnRH pulse generation.
Understandable models Of music collections based on exhaustive feature generation with temporal statistics (2006)

Data mining in large collections of polyphonic music has recently received increasing interest by companies along with the advent of commercial online distribution of music. Important applications include the categorization of songs into genres and the recommendation of songs according to musical similarity and the customer's musical preferences. Modeling genre or timbre of polyphonic music is at the core of these tasks and has been recognized as a difficult problem. Many audio features have been proposed, but they do not provide easily understandable descriptions of music. They do not explain why a genre was chosen or in which way one song is similar to another. We present an approach that combines large scale feature generation with meta learning techniques to obtain meaningful features for musical similarity. We perform exhaustive feature generation based on temporal statistics and train regression models to summarize a subset of these features into a single descriptor of a particular notion of music. Using several such models we produce a concise semantic description of each song. Genre classification models based on these semantic features are shown to be better understandable and almost as accurate as traditional methods.
Conjugated Microporous Polymers via Solvent-Free Ionothermal Cyclotrimerization of Methyl Ketones (2021)

Conjugated microporous polymers (CMPs) are porous organic materials that display (semi)conducting behavior due to their highly π-conjugated structures. As such, they are promising next-generation materials for applications requiring both conductivity and porosity, such as supercapacitive energy storage and electrochemical sensing. However, most CMPs and related porous aromatic frameworks (PAFs) are currently prepared using expensive transition metal-based catalysts under solvothermal conditions, significantly increasing their manufacturing costs. Herein, we demonstrate that the ionothermal cyclotrimerization of methyl ketones via the aldol reaction represents a new strategy for the solvent-free synthesis of CMPs and PAFs. Specifically, we show that 1,3,5-triacetylbenzene and tetrakis(4-acetylphenyl)methane can be polymerized in molten zinc chloride to produce highly conjugated and microporous materials, as confirmed by 77 K N2 adsorption measurements in conjunction with UV–vis, Raman, and solid-state NMR spectroscopies. The CMP prepared from 1,3,5-triacetylbenzene demonstrates higher charge storage capacities (up to 172 F/g) than a commercially available supercapacitor carbon, reflecting the promise of cyclotrimerized CMPs for electrical energy storage applications.
Characteristic Mode Analysis of a Vertical Dipole Above Lossy Dielectric Half-space (2018)

This paper proposes a novel formulation for determining the characteristic modes of a vertical electric dipole aligned in dielectric half-space. Complex image techniques have been employed to determine the corresponding field integral equation. The modal perturbation due to the dielectric ground has been compared with various heights for better physical understanding.
Tin-containing silicates: identification of a glycolytic pathway via 3-deoxyglucosone (2016)

We identify a glycolytic pathway through 3-deoxyglucosone using Lewis acid catalysts resulting in the formation of bio-based monomers.
Multipotential Neural Precursors Transplanted into the Metachromatic Leukodystrophy Brain Fail to Generate Oligodendrocytes but Contribute to Limit Brain Dysfunction (2008)

Neural stem cells appear to be best suited for regenerative therapy in neurological diseases. However, the effects of high levels of potentially toxic substances such as sulfatides--which accumulate in metachromatic leukodystrophy (MLD)--on this regenerative ability are still largely unclear. To start addressing this question, in vitro and in vivo experiments were used to examine the behavior of multipotential neural precursors exposed to abnormally high levels of sulfatides. Following transplantation of dissociated neurospheres into the brain of presymptomatic MLD pups, the majority of donor-derived cells were distributed in a caudal to rostral direction, with higher numbers in the cortex. Most if not all of the donor cells acquired an astroglial phenotype. We found no evidence of oligodendrocyte or neuronal commitment of transplanted cells in long-term-treated MLD mice (e.g. up to 1.5 years of age). This was in line with our in vitro findings of sulfatides blocking oligodendrocyte formation after induction of differentiation in sulfatide-treated epidermal growth factor/fibroblast growth factor responsive neurospheres. Transplanted MLD mice showed an improved arylsulfatase A (ARSA) activity and a significant amelioration of sulfatide metabolism, neurodegeneration and motor-learning/memory deficits. Furthermore, transplanted cells were shown to act as a source of ARSA enzyme that accumulated in endogenous brain cells, indicating the occurrence of enzyme cross-correction between transplanted and host cells. These results provide a first insight into the effect of sulfatides on the stemness properties of neural stem cells and on the effects of the MLD environment on the in vivo expectations of using neural stem cells in cell therapy.
Kanji snap (2013)

As optical character recognition techniques improve, new opportunities to improve existing systems open up. There are for example OCR reading aids for the visually impaired and applications for translating foreign text by capturing photos with smartphones. But one field that hasn't made use of the advancing technology is the learning environment. This demo concentrates on incorporating optical character recognition into a smartphone application for learning Japanese kanji characters. With the application users can take photos of kanji in their everyday environment and look up detailed information and translations easily. Users can practice those kanji with vocabulary lists and quizzes and track their study progress.
Non‐invasive algorithm of enhanced liver fibrosis and liver stiffness measurement with transient elastography for advanced liver fibrosis in chronic hepatitis B (2013)

An Enhanced Liver Fibrosis - liver stiffness measurement algorithm could improve the accuracy of prediction of either ELF or LSM alone. Liver biopsy could be correctly avoided in approximately 60% of patients.
Protein Extraction from Heat-Stabilized Defatted Rice Bran. 1. Physical Processing and Enzyme Treatments (2002)

Physical processing with or without enzyme treatments on protein extraction from heat-stabilized defatted rice bran (HDRB) was evaluated. Freeze-thaw, sonication, high-speed blending, and high-pressure methods extracted 12%, 15%, 16%, and 11% protein, respectively. Sonication (0-100%, 750 W), followed by amylase and combined amylase and protease treatments, extracted 25.6-33.9% and 54.0-57.8% protein, respectively. Blending followed by amylase and protease treatment extracted 5.0% more protein than the nonblended enzymatic treatments. High-pressure treatments, 0-800 MPa, with water or amylase-protease combinations, extracted 10.5-11.1% or 61.8-66.6% protein, respectively. These results suggest that physical processing in combination with enzyme treatments can be effective in extracting protein from HDRB.
Preliminary Results of the NINDS/NIBIB Consensus Meeting to Evaluate Pathological Criteria for the Diagnosis of CTE (P2.178) (2015)

OBJECTIVE: To establish neuropathological consensus criteria for the diagnosis of chronic traumatic encephalopathy (CTE). BACKGROUND: CTE is a neurodegeneration that is associated with repetitive, mild traumatic brain injury. CTE can only be diagnosed with certainty by neuropathological examination of brain tissue. DESIGN/METHODS: Pathological criteria have been proposed for the neuropathological diagnosis of CTE (McKee et al., Brain 2013): 1. Perivascular foci of hyperphosphorylated (p-tau) immunoreactive neurofibrillary tangles (NFTs) and astrocytic tangles (ATs) in the neocortex. 2. Irregular clusters of p-tau immunoreactive NFTs and ATs found preferentially at the sulcal depths. 3. NFTs in the cerebral cortex located primarily in the superficial layers. Supportive, but non-diagnostic, features are 4. Clusters of subpial ATs in the cerebral cortex, most pronounced at the sulcal depths. A group of expert neuropathologists will independently analyze slides from cases of CTE and other tauopathies using the provisional criteria. The neuropathologists will evaluate the cases independently, - first, blinded to the clinical history and gross neuropathological features, and second, after being supplied the additional information. The cases to be evaluated will include, but are not restricted to, CTE, Alzheimer’s disease, progressive supranuclear palsy, argyrophilic grain disease, corticobasal degeneration, primary age-related tauopathy and parkinsonism dementia complex of Guam. A single laboratory will process all slides to assure conformity. The reliability of the criteria for the diagnosis of CTE will be determined by measuring group agreement among the neuropathologists using kappa and intra-cluster correlation (ICC) statistics. Sensitivity, specificity and positive predictive values will also be estimated for each rater. RESULTS and CONCLUSIONS: The findings will be discussed at a consensus conference to be held in late February 2015 and the preliminary results of this conference will be presented. Study Supported by: NINDS and NIBIB Cooperative agreement, 1U01NS086659-01 and 1U01NS086625-01.
Mechanical continuity and reversible chromosome disassembly within intact genomes removed from living cells (1997)

Chromatin is thought to be structurally discontinuous because it is packaged into morphologically distinct chromosomes that appear physically isolated from one another in metaphase preparations used for cytogenetic studies. However, analysis of chromosome positioning and movement suggest that different chromosomes often behave as if they were physically connected in interphase as well as mitosis. To address this paradox directly, we used a microsurgical technique to physically remove nucleoplasm or chromosomes from living cells under isotonic conditions. Using this approach, we found that pulling a single nucleolus or chromosome out from interphase or mitotic cells resulted in sequential removal of the remaining nucleoli and chromosomes, interconnected by a continuous elastic thread. Enzymatic treatments of interphase nucleoplasm and chromosome chains held under tension revealed that mechanical continuity within the chromatin was mediated by elements sensitive to DNase or micrococcal nuclease, but not RNases, formamide at high temperature, or proteases. In contrast, mechanical coupling between mitotic chromosomes and the surrounding cytoplasm appeared to be mediated by gelsolin-sensitive microfilaments. Furthermore, when ion concentations were raised and lowered, both the chromosomes and the interconnecting strands underwent multiple rounds of decondensation and recondensation. As a result of these dynamic structural alterations, the mitotic chains also became sensitive to disruption by restriction enzymes. Ion-induced chromosome decondensation could be blocked by treatment with DNA binding dyes, agents that reduce protein disulfide linkages within nuclear matrix, or an antibody directed against histones. Fully decondensed chromatin strands also could be induced to recondense into chromosomes with pre-existing size, shape, number, and position by adding anti-histone antibodies. Conversely, removal of histones by proteolysis or heparin treatment produced chromosome decondensation which could be reversed by addition of histone H1, but not histones H2b or H3. These data suggest that DNA, its associated protein scaffolds, and surrounding cytoskeletal networks function as a structurally-unified system. Mechanical coupling within the nucleoplasm may coordinate dynamic alterations in chromatin structure, guide chromosome movement, and ensure fidelity of mitosis. J. Cell. Biochem. 65:114–130. © 1997 Wiley-Liss, Inc.
Cutting balloon angioplasty vs. conventional balloon angioplasty in patients receiving intracoronary brachytherapy for the treatment of in‐stent restenosis (2004)

The objective of this study was to evaluate the safety and efficacy of cutting balloon angioplasty (CBA) for the treatment of in-stent restenosis prior to intracoronary brachytherapy (ICB). Cutting balloon angioplasty may reduce the incidence of uncontrolled dissection requiring adjunctive stenting and may limit "melon seeding" and geographic miss in patients with in-stent restenosis who are subsequently treated with ICB. We performed a retrospective case-control analysis of 134 consecutive patients with in-stent restenosis who were treated with ICB preceded by either CBA or conventional balloon angioplasty. We identified 44 patients who underwent CBA and ICB, and 90 control patients who underwent conventional percutaneous transluminal coronary angioplasty (PTCA) and ICB for the treatment of in-stent restenosis. Adjunctive coronary stenting was performed in 13 patients (29.5%) in the CBA/ICB group and 41 patients (45.6%; P < 0.001) in the PTCA/ICB group. There was no difference in the injury length or active treatment (ICB) length. The procedural and angiographic success rates were similar in both groups. There were no statistically significant differences in the incidence of death, myocardial infarction, recurrent angina pectoris, subsequent target lumen revascularization, or the composite endpoint of all four clinical outcomes (P > 0.05). Despite sound theoretical reasons why CBA may be better than conventional balloon angioplasty for treatment of in-stent restenosis with ICB, and despite a reduction in the need for adjunctive coronary stenting, we were unable to identify differences in clinical outcome.
A Miniaturized Surface Mount Compatible Quasi-elliptic Response Bandpass Filter Using Multilayer Substrates (2019)

In this paper, a miniaturized UHF band second-order quasi-elliptic response bandpass filter (BPF) is proposed. Traditional UHF transmission line filter suffers from large circuit size and large footprint area. For the purpose of miniaturization, spiral quarter-wavelength short-circuited resonators is used in this BPF filter design. For further footprint reduction, the proposed filter is implemented by stacking multilayer substrates. Coplanar waveguide (CPW) transmission lines are used as input and output ports on the same layer, which can be compatible with surface mounting technology (SMT) effectively. It is observed from simulation and measured results that the return loss and insertion loss at a center frequency of 433 MHz are about 15 dB and 0.7 dB, respectively, with a fractional bandwidth of 19%. Two transmission zeros are located on both sides of the passband. A good agreement is obtained between the simulated and measured results.
Understanding Global Information Technology and Outsourcing Dynamics (2008)

This chapter provides information technology (IT) project leaders, call center management, researchers, and educators with an analytical tool to examine current concerns and anticipate future trends related to globalization and information technology. The authors propose to use a multi-lens analysis as a framework for evaluating outsourcing opportunities. This approach offers a valuable and effective full-circle methodology for assessing technological, political, organizational, economic, legal, educational, and cultural considerations that encourage a fuller understanding of the issues, problems, and opportunities that globalization and technological innovation creates. An understanding of these factors related to outsourcing and other technical collaborative projects can avoid costly miscalculations, reduce misunderstandings, and promote mutually beneficial results. Outsourcing is part of a larger socio-political and cultural process, and extends beyond the narrow parameters of economic and technological considerations. The discussion of the various lenses is supported by relevant material from case studies and qualitative interview data collected by the authors in Germany and India from IT experts, call center managers, and call center agents.
Measurement of cholesterol of major serum lipoprotein classes by anion-exchange HPLC with perchlorate ion-containing eluent (2003)

We have developed a high-performance liquid chromatography (HPLC) method for measurement of cholesterol in the major classes of serum lipoproteins, i.e., HDL, LDL, IDL, VLDL, and chylomicrons. Lipoproteins in serum were separated on a column containing diethylaminoethyl-ligand nonporous polymer-based gel by elution with a step gradient of sodium perchlorate concentration, and detected by post-column reaction with a reagent containing cholesterol esterase and cholesterol oxidase. The within-day assay and between-day assay coefficients of variation for cholesterol concentration in lipoproteins were in the ranges of 0.9-6.4% and 1.1-11.9%, respectively. The correlation coefficients between the values of HDL, LDL, IDL, VLDL, and chylomicron cholesterol measured by the HPLC method and those estimated by an ultracentrifugation method were 0.892, 0.921, 0.840, 0.930, and 0.873, respectively. Values of remnant-like particle cholesterol measured by an immunoseparation technique (Japan Immunoresearch Laboratories, Japan) were significantly correlated with VLDL and chylomicron cholesterol values measured by the HPLC method (r = 0.883 and r = 0.729, respectively). This rapid and accurate HPLC method was successfully applied to the analysis of plasma lipoproteins of patients with hyperlipidemia.