gebhart/patrepeval huggingface dataset:
Observer-Based Control Methods for Combined Source-Voltage Harmonics and Unbalance Disturbances in PWM Voltage-Source Converters (2009)

In this paper, computationally efficient sinusoidal-disturbance estimation and elimination methods are introduced into the control of an active front end (AFE) voltage-source converter (VSC) to achieve effective disturbance rejection in high power systems with slower pulsewidth-modulation switching frequencies (e.g., 5 kHz) and limited current-controller bandwidth. Since the active rectifier is in series with the source and the load, there is no need to add additional hardware for harmonic elimination. The input positive- and negative-sequence voltages are extracted using the new observer methods, and negative-sequence currents are injected to eliminate the dc-link 120-Hz ripple. The observer-based disturbance-rejection methods are proven to be very effective when all three types of disturbances (input-voltage harmonics, unbalance, and inductor unbalance) coexist simultaneously, even under input-inductance variations of 30%. Simulation results are verified experimentally using a 15-hp adjustable-speed-drive system that includes an AFE VSC coupled to a dSpace controller.
Effects of hereditary retinal degeneration due to a CEP290 mutation on the feline pupillary light reflex (2010)

The PLR of cats had multiple phases, with a remarkably high-amplitude 'paradoxical' off-constriction even in the absence of retinal disease. In rdAc cats, reduced irradiance sensitivity was consistent with progressive loss of rod and cone function. Based on previously characterized retinal pathology, this suggests the visual streak of the retina has a proportionally large contribution to PLR input. These findings support the hypothesis that the efficacy of planned therapeutic trials can be determined by careful evaluation of the PLR in cats.
An idiopathic upper alimentary tract ulcerative syndrome in weaned dairy calves in Victoria, Australia (2020)

An idiopathic clinical syndrome had been described in weaned dairy calves in the state of Victoria, Australia, where affected animals presented with diarrhoea, ill-thrift, enteritis and ulceration of the upper alimentary tract, with occasional oral/nasal ulcers. Between 7 November 2016 and 31 March 2019, 34 Victorian cattle herds were investigated, after each reported five or more weaned calves with diarrhoea and/or ill-thrift, or at least one calf with oral/nasal ulceration. Primary study objectives included the development of a detailed case definition for the clinical syndrome, termed upper alimentary tract ulcerative syndrome (UAUS) and the identification of potential causative virus(es) using metagenomics. A diagnosis of UAUS could not be made based solely on clinical signs and required histopathological assessment of post-mortem samples. Specifically, this included the identification of multifocal to coalescing areas of mucosal epithelial necrosis at all depths of the stratified squamous epithelium of the oesophagus, along with exclusion of bovine viral diarrhoea virus. Based on this case definition, twelve herds were diagnosed with clinical UAUS across the three dairying regions of Victoria, while thirteen were ruled UAUS-negative. The status of the nine remaining herds was unresolved due to a lack of required post-mortem samples. Metatranscriptomic analysis on oral swabs and oesopharyngeal samples from confirmed UAUS cases did not detect a virus common to the cross-sectional sample collection.
DOMAIN-CROSSING SOFTWARE PRODUCT LINES IN EMBEDDED, AUTOMOTIVE SYSTEMS (2005)

The development of software-functions in the automotive domain is subject to multiple conditions. These conditions are for example the rising number of various functions in the car, the simultaneously increasing cost pressure and shortened development cycles. To come up with these conditions, an improvement of reuse is very promising. In this paper the point of view is that a software-function is separable in two domains, the application-domain and the standard-software-domain. Looking at the reuse activities of both domains together provides more generality and synergy-effects. A reuse approach that fits both domains is the approach of domain-crossing software product lines. This paper reports about an ongoing research project about adapting of software product lines in the specific domains and describes a concept for bringing them together. For proving the concept an accompanying tool was implemented and is introduced afterwards.
Plasmonic germanium resonators for CMOS compatible Terahertz chem-bio sensing platform (2017)

Plasmon resonance based biosensors are considered as one of the most sensitive bio detection methods, in which the sensitivity is of the order of a single biomolecule due to extremely high enhancement of the electromagnetic field. Although established metal plasmonic biosensors are extremely sensitive, they suffer from integration issues due to non-compatibility to standard semiconductor fabrication technology (CMOS technology) [1]. Additionally, metal plasmonic sensors operate in the Near IR to visible spectral range, therefore, essentially leaving a gap in the Terahertz (THz) spectral regime which is interesting for biological applications like detection of conformational changes in proteins. On the other hand, doped semiconductor materials show plasmonic behaviour in the THz spectral regime [1, 2], and can be integrated on standard semiconductor foundry processes. This work demonstrates plasmon based Germanium (Ge) resonators fabricated on standard BiCMOS technology operating at THz frequency range for chem-bio sensing.
A Study on the Application Infrared Thermography Camera for the 7FA Gas Turbine Blade Covering Crack Detecting (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
SBAS and GBAS Integrity for Non-Aviation Users: Moving Away from "Specific Risk" (2011)

SBAS and GBAS enhance standalone GNSS navigation to meet the safety and availability requirements of civil aviation. SBAS and GBAS are also freely available to other users, such as automobiles, buses, and trains on land as well as ships near shore. However, integrity as implemented there are significant differences between the aviation interpretation of navigation integrity and the one that would be natural to most users. This paper explains the differences between “specific risk” as defined by aviation and “average risk,” which is used in most other fields and which is the foundation of Probabilistic Risk Assessment (PRA). Maximum errors for the FAA WAAS version of SBAS are presented and compared to the protection levels determined from WAAS to support aviation approach operations to illustrate the degree of conservatism that is built into the “specific risk” interpretation of integrity. Based on this information, several means are proposed to remove this conservatism from SBAS and GBAS for non-aviation users who do not need it. The resulting benefits, in terms of smaller error bounds and/or improved availability, can be substantial.
Aromas from Quebec. V. Essential oils from the fruits and stems of Heracleum maximum Bartram and their unsaturated aliphaticacetates (2016)

Both the fruits and stems of Heracleum maximum Bartram, a common Apiaceae found throughout northern North America, have been traditionally consumed as spice and food by American First Nations and settlers. As both parts of the plant bear a distinctive scent, they have been submitted to volatile constituent extraction and their essential oils were studied by GC–FID and GC–MS. The fruits’ oil was found to be mostly constituted of aliphatic esters, with octyl acetate (65.6%) as main constituent, while the stems yielded a generally terpenic oil, dominated by limonene (45.2%). These results were in line with data for other Heracleum species, and constitute the first study of the volatile constituents of H. maximum. The observation of several octadecenyl acetates as trace compounds in the stems’ oil allowed for the comprehensive identification of these uncommon and closely related isomers.
An altered pattern of circulating apolipoprotein E3 isoforms is implicated in preeclampsia (2008)

Preeclampsia is a common pregnancy complication that is an important cause of preterm birth and fetal growth restriction. Because there is no diagnostic test yet available for preeclampsia, we used a proteomic approach to identify novel serum/plasma biomarkers for this condition. We conducted case control studies comparing nulliparous women who developed preeclampsia at 36-38 weeks of gestation with healthy nulliparous women matched by gestational age at sampling. Serum/plasma was depleted of six abundant proteins and analyzed by two-dimensional gel electrophoresis (n = 12 per group) and difference gel electrophoresis (n = 12 per group). Differences in abundance of protein spots were detected by univariate and multivariate statistical analyses. Proteins were identified by mass spectrometry and expression of selected proteins was validated by immunoblotting. Proteins whose concentrations were selectively associated with preeclampsia included apolipoprotein E (apoE), apoC-II, complement factor C3c, fibrinogen, transthyretin, and complement factor H-related protein 2. An increase in a deglycosylated isoform of apoE3 and concomitantly decreased amounts of one apoE3 glycoisoform were identified in preeclamptic plasma and confirmed by immunoblotting. Altered production of these preeclampsia-related apoE3 isoforms might impair reverse cholesterol transport, contributing to arterial damage. These findings point to a novel mechanistic link between preeclampsia and subsequent cardiovascular disease.
Supernets and snHubs: a foundation for public utility computing (2004)

The notion of procuring computer services from a utility, much the way we get water and electricity and phone service, is not new. The idea at the center of the public utility trend in computer services is to allow firms to focus less on administering and supporting their information technology and more on running their business. Supernets and their implementation as hardware devices (snHubs) are our approach to make networks part of the public utility computing (PUC) infrastructure. The infrastructure is a key to integrating and enabling such &amp;quot;remote access&amp;quot; constituencies as B2B, out-sourcing vendors, and workers who telecommute in a safe and scalable manner. We have designed, developed, and deployed a prototype whose viability is now being demonstrated by a small deployment throughout Sun Microsystems.
Data from First-in-Human Phase I Study of ABBV-838, an Antibody–Drug Conjugate Targeting SLAMF7/CS1 in Patients with Relapsed and Refractory Multiple Myeloma (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;ABBV-838 is an antibody–drug conjugate targeting a unique epitope of CD2 subset 1, a cell-surface glycoprotein expressed on multiple myeloma cells. This phase I/Ib first-in-human, dose-escalation study (trial registration ID: NCT02462525) evaluated the safety, pharmacokinetics, and preliminary activity of ABBV-838 in patients with relapsed and refractory multiple myeloma (RRMM).&lt;/p&gt;Patients and Methods:&lt;p&gt;Eligible patients (≥18 years) received ABBV-838 (3+3 design) intravenously starting from 0.6 mg/kg up to 6.0 mg/kg for 3-week dosing intervals (Q3W). Patients could continue ABBV-838 for up to 24 months. Assessment of alternate dosing intervals (Q1W and Q2W) was conducted in parallel.&lt;/p&gt;Results:&lt;p&gt;As of March 2017, 75 patients received at least one dose of ABBV-838. The most common any-grade treatment-emergent adverse events (TEAE) were neutropenia and anemia (28.0% each), fatigue (26.7%), and nausea (25.3%). Grade 3/4/5 TEAEs were reported in 73.3% of patients across all treatment groups; most common were neutropenia (20.0%), anemia (18.7%), and leukopenia (13.3%). Grade 3/4/5 ABBV-838–related TEAEs were reported by 40.0% of patients across all treatment groups. Overall, 4.0% of patients experienced TEAEs leading to death, none ABBV-838 related. The MTD was not reached; the selected recommended dose for the expansion cohort was 5.0 mg/kg Q3W. Pharmacokinetic analysis showed that exposure was approximately dose proportional. The overall response rate was 10.7%; very good partial responses and partial responses were achieved by 2 (2.7%) and 6 (8.0%) patients, respectively.&lt;/p&gt;Conclusions:&lt;p&gt;These results demonstrate that ABBV-838 is safe and well-tolerated in patients with RRMM with a very limited efficacy.&lt;/p&gt;&lt;/div&gt;
Crystallization, X-ray diffraction and preliminary structure analysis of Mycobacterium tuberculosis chaperonin 10 (1999)

The Mycobacterium tuberculosis chaperonin 10 (Mtcpn10) has been crystallized by the sitting-drop vapour-diffusion method. The crystals belong to the monoclinic space group P21, with unit-cell parameters a = 76.5, b = 87.9, c = 124.4 A, beta = 106.8 degrees. X-ray diffraction data were collected to 2.8 A. The self-rotation function and the molecular-replacement solution show that the asymmetric unit contains a dimer of heptamers related by twofold non-crystallographic symmetry. The two heptamers interact through interleaving flexible loops in a similar fashion to M. leprae and Gp31 cpn10. In addition to its role in protein folding, Mtcpn10 has unique effects on the growth of host cells and is a major immunogen in tuberculosis infections. The structure determination will permit the analysis of the amino acids identified as important for the protein-folding and cell-signalling activity of Mtcpn10.
Rapid Photoligation of Gold Nanocolloids with Lipoic Acid-Based Ligands (2020)

An effective and easy to implement ligand exchange strategy is paramount to the design of stable and multifunctional gold and other inorganic nanocolloids. This is also crucial for their use in biology and medicine. In this contribution, we demonstrate that photomediated ligand substitution of gold nanocrystals with a series of lipoic acid-modified ligands yields several advantages, including rapid phase transfer and great long-term colloidal stability. This strategy combines photochemical reduction of the dithiolane group with energetically favorable in situ ligand chemisorption, yielding rapid modification of the surfaces. It requires substantially smaller amounts of excess ligands compared to conventional incubation starting with the oxidized form of the ligands. Complete substitution of the ligands is confirmed by using 1H NMR and FT-IR spectroscopy. The colloidal properties of the resulting materials have been tested by using a combination of long-term stability in ion-rich media, sodium cyanide digestion, and dithiothreitol competition tests. They show that photoligation preserves the structure and photophysical properties of the various colloids. Mechanistic arguments have been discussed to explain the effectiveness of this ligation strategy. These findings prove the practical benefits of this approach for designing biocompatible gold colloids and bode well for using such materials in a variety of biological assays and photothermal therapy.
Efficient H2-producing photocatalytic systems based on cyclometalated iridium- and tricarbonylrhenium-diimine photosensitizers and cobaloxime catalysts (2008)

Quantum yield values up to 16% under visible irradiation associated with high turnover frequencies ( approximately 50 h(-1)) and stability (up to 273 turnovers), characterize the new photocatalytic systems for hydrogen production, based on diimine derivatives of ruthenium, cyclometallated iridium or tricarbonylrhenium as photosensitizers and cobaloxime H2-evolving catalytic centers, which are among the most efficient molecular systems reported so far and compete with some platinum-based systems.
Nemacol is a Small Molecule Inhibitor of C. elegans Vesicular Acetylcholine Transporter with Anthelmintic Potential (2022)

Abstract Nematode parasites of humans and livestock pose a significant burden to human health, economic development, and food security. Anthelmintic drug resistance is widespread among parasites of livestock and many nematode parasites of humans lack effective treatments. Here, we present a nitrophenyl-piperazine scaffold that induces motor defects rapidly in the model nematode Caenorhabditis elegans . We call this scaffold Nemacol and show that it inhibits the vesicular acetylcholine transporter (VAChT), a target recognized by commercial animal and crop health groups as a viable anthelmintic target. We demonstrate that it is possible to create Nemacol analogs that maintain potent in vivo activity whilst lowering their affinity to the mammalian VAChT 10-fold. We also show that Nemacol synergizes with the anthelmintic ivermectin to kill C. elegans . Hence, Nemacol represents a promising new anthelmintic scaffold that acts through an identified viable anthelmintic target. One sentence summary A small molecule screen identifies a vesicular acetylcholine transporter inhibitor scaffold that incapacitates parasitic nematodes
Effects of Gamma Irradiation and Electrical Stress on a-Si:H Thin-Film Transistors for Flexible Electronics and Displays (2011)

The change in electrical characteristics of a-Si:H thin-film transistors (TFTs) was determined in the presence of electrical gate bias stress, gamma radiation, and both simultaneously, simulating the harsh environment of space. Multiple TFTs were tested under each condition, and the current-voltage characteristics were measured. The results show the gate bias stress increasing the threshold voltage ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">VT</i> ) with power law time dependence while the gamma irradiation decreases threshold voltage for all working transistors. When both the irradiation and gate bias stress were applied simultaneously, the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">VT</i> initially increased with electrical stress and then decreased as the gamma radiation dominated. Changes in effective mobility were also extracted and detailed analysis of the current-voltage characteristics indicated that the gamma radiation creates interface traps and electron-hole pairs whereas the gate stress produces defect states in the amorphous silicon.
Evidence for Radical-Mediated Catalysis by HppE: A Study Using Cyclopropyl and Methylenecyclopropyl Substrate Analogues (2012)

(S)-2-Hydroxypropylphosphonic acid epoxidase (HppE) is an unusual mononuclear iron enzyme that catalyzes the oxidative epoxidation of (S)-2-hydroxypropylphosphonic acid ((S)-HPP) in the biosynthesis of the antibiotic fosfomycin. HppE also recognizes (R)-2-hydroxypropylphosphonic acid ((R)-HPP) as a substrate and converts it to 2-oxo-propylphosphonic acid. To probe the mechanisms of these HppE-catalyzed oxidations, cyclopropyl- and methylenecyclopropyl-containing compounds were synthesized and studied as radical clock substrate analogues. Enzymatic assays indicated that the (S)- and (R)-isomers of the cyclopropyl-containing analogues were efficiently converted to epoxide and ketone products by HppE, respectively. In contrast, the ultrafast methylenecyclopropyl-containing probe inactivated HppE, consistent with a rapid radical-triggered ring-opening process that leads to enzyme inactivation. Taken together, these findings provide, for the first time, experimental evidence for the involvement of a C2-centered radical intermediate with a lifetime on the order of nanoseconds in the HppE-catalyzed oxidation of (R)-HPP.
The wireless revolution (1991)

Current demand for and recent developments in wireless communication are described. Funding for wireless worldwide is examined. Tools and techniques used to characterize radio propagation are discussed, and some research results are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Noninvasive Confocal Raman Imaging of Immiscible Liquids in a Porous Medium (1997)

The physical properties of a porous medium impregnated by a liquid or vapor are dictated in part by the spatial distribution of these phases within the solid host matrix and by physicochemical interactions at the solid−liquid−vapor boundaries. We report on a novel 3-D imaging technique based on the high spatial resolution and chemical specificity of the confocal Raman microscope, which allows for the first time the in situ study and visualization of these processes. Images showing the topology of immiscible liquids (trichloroethylene−water) in a natural porous sandstone demonstrate the potential of the technique and reveal a rich variety of interfacial phenomena.
Cell‐Based Biological Evaluation of a New Bisamide FMS Kinase Inhibitor Possessing Pyrrolo[3,2‐c]pyridine Scaffold (2014)

A bisamide compound 1 possessing the pyrrolo[3,2-c]pyridine nucleus was synthesized and biologically evaluated. It was tested for kinase inhibitory activity over a panel of 47 kinases, and its selectivity toward the FMS kinase was accidentally discovered. Compound 1 was tested over a panel of seven ovarian, two prostate, and six breast cancer cell lines at a single dose concentration of 10 µM and showed high activity. It was further tested in a 5-dose mode to determine its IC50 and total growth inhibition (TGI) values over the 15 cell lines. Compound 1 showed high potency on the submicromolar scale and good efficacy. The cytotoxic effect of compound 1 over peritoneal macrophages was also investigated. Compound 1 demonstrated higher selectivity against different cancer cell lines compared with HS-27 fibroblasts.
A novel schema to recover carbon dioxide (2013)

The concentration of carbon dioxide (CO2) in the atmosphere has increased significantly from about 280 ppm in 1750 (pre-industrial era) to 367 ppm in 1999 and to 379 ppm in 2005. The industry accounts for one-third of all the energy used globally and for almost 40% of worldwide CO2 emissions. However, although CO2 capture is a global issue, there is no simple solution that can be applied on a global scale. Absorption using amines (e.g., monoethylamine, MEA) is the reference technology to separate CO2 from flue gases in a post-combustion scenario and it is widely used in spite of the multiple disvadvantages (e.g. energy consumption, solvent toxicity) due to its maturity.
Carbohydrate‐Based Nanocarriers Exhibiting Specific Cell Targeting with Minimum Influence from the Protein Corona (2015)

Whenever nanoparticles encounter biological fluids like blood, proteins adsorb on their surface and form a so-called protein corona. Although its importance is widely accepted, information on the influence of surface functionalization of nanocarriers on the protein corona is still sparse, especially concerning how the functionalization of PEGylated nanocarriers with targeting agents will affect protein corona formation and how the protein corona may in turn influence the targeting effect. Herein, hydroxyethyl starch nanocarriers (HES-NCs) were prepared, PEGylated, and modified on the outer PEG layer with mannose to target dendritic cells (DCs). Their interaction with human plasma was then studied. Low overall protein adsorption with a distinct protein pattern and high specific affinity for DC binding were observed, thus indicating an efficient combination of "stealth" and targeting behavior.