gebhart/patrepeval huggingface dataset:
Design Methodology of N-Path Filters With Adjustable Frequency, Bandwidth, and Filter Shape (2018)

In this paper, an adaptive N-path filter design technique is presented. The filter designed by this method can be reconfigured to different shapes, e.g., Butterworth or Chebyshev with variable bandwidth (BW), based on the user requirements. In addition, an analytical synthesis procedure is introduced to realize high-order bandpass filters (BPFs) based on N-path architecture with a prescribed set of specifications. A proof-of-concept BPF is fabricated and measured in a 65-nm CMOS process. The filter can be reconfigured to realize different filter shapes by changing coupling capacitors. The BW of the proposed filter is also tunable. The passband of the filter is tunable from 0.2 to 1.2 GHz with a gain of 14.5-18 dB, a noise figure of 3.7-5.5 dB, and a total power consumption of 37.5-52.7 mW. The channel BW can be varied from 20 to 40 MHz and the filter out-of-band third-order intercept point (Δf=50$ MHz) is 25 dBm.
Improved hematopoiesis in GS-nitroxide (JP4-039)-treated mouse long-term bone marrow cultures and radioresistance of derived bone marrow stromal cell lines. (2015)

Chronic treatment of bone marrow cultures and derived stromal cell lines with JP4-039 was non-toxic, and conferred resistance to oxidative stress.
Adenoviral Vectors (1999)

Adenoviral vectors are among the most promising gene transfer vehicles for the in vivo treatment of a range of human diseases, e.g. cystic fibrosis and haemophilia. They have also been used for ex vivo therapies. Adenoviruses can infect a wide spectrum of cell types, including quiescent cells. Replication-deficient vectors can be produced easily and at high titres, but transgene expression is transient, often lasting less than one month. Adenoviruses have been used in live vaccines with no association with any type of tumour. The main disadvantage of adenoviral vectors is the stimulation of the host immune response, both cellular and humoral. Strategies to circumvent this include more extensive deletions and modified cell lines to propagate the vectors. First-generation adenoviral vectors may be applied where short-term expression and single dosing is adequate, such as cancer vaccine therapies. Improved gene transfer methods and more attenuated vectors might enable long-term gene therapy.
HDFx: A Recently Discovered Biologic and its Potential Use in Prevention and Treatment of Hemorrhagic Fever Viruses and Antibiotic-Resistant Superbugs (2016)

Recently, we have reported on the discovery of a new, conserved protein (35-40 kDa) that protects rats, mice, guinea-pigs, and rabbits against lethal hemorrhage, endotoxins, live lethal bacterial and fungal microorganisms, and traumatic injuries when given prophylactally and therapeutically. HDFx was found to stimulate several arms of the innate immune system (e.g. macrophages, NK cells). HDFx was also found to stabilize the microcirculation, prevent rupture and leakage of postcapillary venules, prevent adhesion of platelets to endothelium and loss of platelets, stabilize falls in arterial blood pressure, and prevent stasis and pooling of blood in the postcapillary vessels, as observed by intra-vital high-resolution TV microscopy. HDFx also stimulates phagocytic uptake of foreign particulate matter and bacteria by liver Kupffer cells, splenic macrophages, and circulating macrophages. It also prevents explosive release of cytokines and chemokines from macrophages and lymphocytes in animals subjected to live bacteria, endotoxins, trauma and combined injuries. Surprisingly, HDFx was found to accelerate wound healing and aid the regeneration of tissues. Repeated administration of HDFx, over many months, does not result in either diminished protective activity or detectable organ or tissue pathologies. One of the major consequences of infections and wars/conflicts is loss of the ability to regenerate normal physiologic functions of numerous organs and tissues. A major characteristic of invasion of the body by septic-endotoxic microorganisms and hemorrhagic fever viruses (HFVs) is that these entities eventuate in rupture of the microvessels in the capillary circulation of numerous organs and tissues leading to massive blood and fluid loss, making the body susceptible to superimposed infections and loss of immuno-competence. About 100 million people are infected worldwide, annually, with about 60,000 to 75,000 deaths per year from HFVs. Added to these numbers are the numerous hospital-borne and food-borne infections along with infections resulting from major disasters (hurricanes, tornados, earthquakes, etc.) that cause 75,000 to 100,000 deaths per year in the U.S.A. alone. The ability and uniqueness of HDFx to minimize infections, accelerate wound healing, and promote tissue regeneration should greatly aid treatment and recovery of these victims and be of great value in infections from HFVs and on battlefields.
Connections (2015)

Our community has long pursued principles and methods for enabling fluid and effortless collaborations between people and computing systems. Forging deep connections between people and machines has come into focus over the last 25 years as a grand challenge at the intersection of artificial intelligence, human-computer interaction, and cognitive psychology. I will review experiences and directions with leveraging advances in perception, learning, and reasoning in pursuit of our shared dreams.
Immunohistochemical analysis of 4-aminobiphenyl-DNA adducts in oral mucosal cells of smokers and nonsmokers. (1997)

This non invasive method requiring small cell amounts is a tool for monitoring large groups of subjects at risk in primary prevention programs.
Genetic and OtherDNA‐Based Biosensor Applications (2007)

Abstract The interest and research effort into the development of DNA diagnostic tools has increased dramatically and new instruments to detect, analyze, and quantify gene‐specific information are expected to revolutionize healthcare. In this chapter, a number of application fields for DNA‐based biosensors are described, together with some examples highlighting the specific nature of DNA‐based diagnostics, its impact on biosensor requirements, and how specific challenges in the field can be addressed. An overview, illustrated with some original work, provides aspects of a potential route toward affordable DNA‐sensor arrays with a particular focus on multiplexing and compatibility with polymer integration technology.
Simple routes to mono(.eta.5-pentamethylcyclopentadienyl) complexes of molybdenum(V) and tungsten(V) (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSimple routes to mono(.eta.5-pentamethylcyclopentadienyl) complexes of molybdenum(V) and tungsten(V)Robert Clark. Murray, Lauren. Blum, Andy H. Liu, and Richard R. SchrockCite this: Organometallics 1985, 4, 5, 953–954Publication Date (Print):May 1, 1985Publication History Published online1 May 2002Published inissue 1 May 1985https://pubs.acs.org/doi/10.1021/om00124a034https://doi.org/10.1021/om00124a034research-articleACS PublicationsRequest reuse permissionsArticle Views887Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ultralow-loss silicon ring resonators (2012)

We experimentally demonstrate silicon ring resonators with internal quality factors of Q(0)=2.2×10(7), corresponding to record 2.7 dB/m propagation losses. Importantly, we show that these propagation losses are limited by bend loss, indicating that the propagation loss limit for silicon has not yet been reached.
Three-Dimensional NEGF Simulations of Constriction Tunnel Barrier Silicon Nanowire MUGFETs (2009)

In this paper, we investigate the effect of cross-section variations in nanowire MUGFETs through 3D quantum simulations based on Non-Equilibrium Green's Function (NEGF) formalism. We show that the effect of cross-section variations in a nanowire results in energy barriers in the conduction band that can be interpreted as a local increase of the bandgap. In narrow nanowires with a cross section of a few nanometers, this can strongly influence the current and the characteristics of the device. A small constriction resulting in a barrier of the order of a 0.1eV is shown to be an effective way to create a tunnel barrier that can be used to improve the on/off current ratio in ultra-scaled transistors.
Escher: A Web Application for Building, Sharing, and Embedding Data-Rich Visualizations of Biological Pathways (2015)

Escher is a web application for visualizing data on biological pathways. Three key features make Escher a uniquely effective tool for pathway visualization. First, users can rapidly design new pathway maps. Escher provides pathway suggestions based on user data and genome-scale models, so users can draw pathways in a semi-automated way. Second, users can visualize data related to genes or proteins on the associated reactions and pathways, using rules that define which enzymes catalyze each reaction. Thus, users can identify trends in common genomic data types (e.g. RNA-Seq, proteomics, ChIP)--in conjunction with metabolite- and reaction-oriented data types (e.g. metabolomics, fluxomics). Third, Escher harnesses the strengths of web technologies (SVG, D3, developer tools) so that visualizations can be rapidly adapted, extended, shared, and embedded. This paper provides examples of each of these features and explains how the development approach used for Escher can be used to guide the development of future visualization tools.
Immunoglobulin G (IgG) Anti-Tissue Transglutaminase Antibodies Used as Markers for IgA-Deficient Celiac Disease Patients (2005)

The role of immunoglobulin A (IgA) anti-tissue transglutaminase antibodies (IgA-tTG) as predictors of untreated celiac disease (CoD) is well documented, and the presence and levels of these antibodies are most accurately monitored with native or recombinant human antigens. However, IgA-deficient CoD patients are not identified by IgA serology, and conflicting results concerning the diagnostic validity of IgG antibodies against gliadin (IgG-AGA), endomysium (IgG-EmA), and tTG (IgG-tTG) have been reported. The aim of the present study was to evaluate the utility of IgG-tTG for the detection of CoD in IgA-deficient patients. Samples from 115 IgA-deficient and 200 IgA-sufficient subjects were collected and tested for the presence of IgA and IgG antibodies against tTG, EmA, and AGA. Antibodies against tTG were measured by an enzyme-linked immunosorbent assay based on recombinant human tTG, and antibodies against EmA were determined by immunofluorescence. The values for IgG-tTG showed a higher correlation (correlation coefficient [r] = 0.91) with those for IgG-EmA for the IgA-deficient subjects than for the IgA-sufficient subjects (r = 0.88). The overall concordance of the positive and negative results between IgG-tTG and IgG-EmA was 97%, and the IgG-tTG assay discriminated between IgG-EmA-positive and -negative subjects with IgA deficiency at a rate of 100%. Elevated levels of IgG-tTG and IgG-EmA were measured in 70% of the IgA-sufficient subjects. IgG-tTG detection with recombinant human tTG is a good alternative to IgG-EmA detection, and the addition of IgG-tTG assessment to present screening methods may improve the ability to identify IgA-deficient subjects with CoD.
Preparation and evaluation of magnetic nanocomposite fibers containingα″-Fe16N2andα-Fe nanoparticles in polyvinylpyrrolidone via magneto-electrospinning (2015)

Two kinds of ferromagnetic nanocomposite fiber comprising α″-Fe16N2 and α-Fe nanoparticles (NPs), which have the highest magnetic moments as hard and soft magnetic materials, respectively, embedded in polyvinylpyrrolidone (PVP) have been synthesized via the magneto-electrospinning method. Both α″-Fe16N2 and α-Fe were single-domain core-shell NPs with an average outer diameter of 50 nm and Al2O3 as the shell. Ferrofluid precursors used for the electrospinning were prepared by dispersing these NPs in a PVP-toluene-methanol solution. The results show that applying the magnetic field in the same direction as the electric field resulted in smaller and more uniform fiber diameters. Nanocomposite fibers containing α″-Fe16N2 had smaller diameters than those containing α-Fe NPs. These magnetic-field effects on the fiber formation were explained by referring to the kinetic energy of the moving jet in the electrospinning process. In addition, magnetic hysteresis curves showed an enhancement of the magnetic coercivity (H(c)) and remanence (M(r)) by 22.9% and 22.25%, respectively. These results imply a promising possibility of constructing bulk magnetic materials using α″-Fe16N2 NPs, which furthermore reveals attractive features for many other magnetic applications, such as magnetic sensors.
Detection de Ruptures Multiples dans des Series Temporelles Multivariees (2006)

Nous considerons le probleme de detection de ruptures multiples pour des series chronologiques multivariees, y compris des processus fortement dependants, avec un nombre inconnu de ruptures. Nous supposons que la structure de covariance de ces series chronologiques change de facon abrupte a des dates inconnues. La methode adaptative proposee ici est capable de detecter des ruptures dans des series multivariees independantes et identiquement distribuees (i.i.d.), faiblement et fortement dependantes. Cette methode adaptative surclasse le critere de Schwartz, principalement dans le cas de donnees faiblement dependantes. Nous considerons des applications a des series chronologiques multivariees de rendements d’indices boursiers journaliers et a des series generees par un marche financier artificiel.
A broadband optical local network based on multiple wavelength and multiple RF subcarriers (2003)

The authors propose a multiwavelength local-access optical network that is capable of supporting multiple services with diverse requirements. Integral to the network is an acousto-optic tunable filter that can select multiple nonadjacent wavelengths simultaneously. The use of multiwavelength selectivity, together with subcarrier multiplexing in the electronic domain, results in simple solutions to many transmission and switching problems in a multiservice setting. An important conclusion is that multiwavelength selectivity can be used to implement many networking functions not easily realized otherwise.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Data from Acquired Resistance to Dasatinib in Lung Cancer Cell Lines Conferred by <i>DDR2</i> Gatekeeper Mutation and <i>NF1</i> Loss (2023)

&lt;div&gt;Abstract&lt;p&gt;The treatment of non–small cell lung cancer has evolved dramatically over the past decade with the adoption of widespread use of effective targeted therapies in patients with distinct molecular alterations. In lung squamous cell carcinoma (lung SqCC), recent studies have suggested that &lt;i&gt;DDR2&lt;/i&gt; mutations are a biomarker for therapeutic response to dasatinib and clinical trials are underway testing this hypothesis. Although targeted therapeutics are typically quite effective as initial therapy for patients with lung cancer, nearly all patients develop resistance with long-term exposure to targeted drugs. Here, we use &lt;i&gt;DDR2&lt;/i&gt;-dependent lung cancer cell lines to model acquired resistance to dasatinib therapy. We perform targeted exome sequencing to identify two distinct mechanisms of acquired resistance: acquisition of the T654I gatekeeper mutation in &lt;i&gt;DDR2&lt;/i&gt; and loss of &lt;i&gt;NF1&lt;/i&gt;. We show that &lt;i&gt;NF1&lt;/i&gt; loss activates a bypass pathway, which confers &lt;i&gt;ERK&lt;/i&gt; dependency downstream of &lt;i&gt;RAS&lt;/i&gt; activation. These results indicate that acquired resistance to dasatinib can occur via both second-site mutations in &lt;i&gt;DDR2&lt;/i&gt; and by activation of bypass pathways. These data may help to anticipate mechanisms of resistance that may be identified in upcoming clinical trials of anti-DDR2 therapy in lung cancer and suggest strategies to overcome resistance. &lt;i&gt;Mol Cancer Ther; 13(2); 475–82. ©2013 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Neuroprotective and Nerve Regenerative Approaches for Treatment of Erectile Dysfunction after Cavernous Nerve Injury (2017)

Erectile dysfunction (ED) is a significant cause of reduced quality of life in men and their partners. Cavernous nerve injury (CNI) during pelvic surgery results in ED in greater than 50% of patients, regardless of additional patient factors. ED related to CNI is difficult to treat and typically poorly responsive to first- and second-line therapeutic options. Recently, a significant amount of research has been devoted to exploring neuroprotective and neuroregenerative approaches to salvage erectile function in patients with CNI. In addition, therapeutic options such as neuregulins, immunophilin ligands, gene therapy, stem cell therapy and novel surgical strategies, have shown benefit in pre-clinical, and limited clinical studies. In the era of personalized medicine, these new therapeutic technologies will be the future of ED treatment and are described in this review.
Online Bandwidth Calendaring: On-the-fly admission, scheduling, and path computation (2017)

The centralized control in Software Defined Networks paves the way for new services like Bandwidth Calendaring (BWC), where the possibility to shift temporally future bandwidth requests allows to efficiently use network resources. Assuming perfect knowledge of the calendar for all future bandwidth reservations is unrealistic. In this paper, we study the online version of the BWC problem presented in [1], where for unpredictable incoming demands an admission decision, scheduling and path allocation must be taken instantaneously. We design an algorithm for solving the online version of the BWC problem and proposes two heuristic approaches to exploit the scheduling flexibility of demands. Our numerical results reveal that the proposed solution approach outperforms state-of-the art methods by up to 70% in terms of accepted traffic.
Intrarenal Dopamine Production and Distribution in the Rat (1997)

Dopamine (DA), produced by the renal proximal tubule, has been demonstrated as an intrarenal paracrine hormone mediating diuresis and natriuresis. The precise mechanism by which DA exerts its cell-to-cell action is not fully understood. In the present study, renal interstitial fluid (RIF) DA (by in vivo microdialysis) and urinary DA excretion (UDAV) were compared in anesthetized rats on either normal (0.28% NaCI, NS) or high (4.0% NaCI, HS) sodium balance and in response to acute gamma-L-glutamyl-L-dopa (gludopa) administration. Urine flow (UV) and sodium excretion (UNaV) in HS were greater than in NS rats. UDAV was increased in HS compared with NS rats. RIF DA was significantly lower in HS than NS rats. Gludopa at 3, 5, and 7.5 nmol/kg (IV bolus) produced a larger increase in UDAV than RIF DA. Only the highest dose of gludopa (7.5 nmol/kg), which resulted in a 7.3-fold increase in UDAV and 1.7-fold increase in RIF DA, was associated with significant diuresis and natriuresis. Cortical and medullary blood flow remained unchanged after gludopa (7.5 nmol/kg) administration, while angiotensin II (100 ng.kg-1.min-1) induced significant reduction in cortical and medullary blood flow. Prior bilateral renal denervation did not have a significant effect on basal DA levels (RIF DA and UDAV) or gludopa-induced DA production or natriuresis and diuresis. These data demonstrated that both chronic sodium loading and acute gludopa administration stimulated renal DA production and release predominantly into the tubule lumen, where DA had a direct tubule action in the control of UNaV. Renal DA production and its renal effects were not significantly regulated by renal sympathetic nerve activity.
Demonstration Experiments Towards Practical IP Traceback on the Internet (2010)

Recently, Distributed Denial of Service (DDoS) attacks have become a critical issue on the Internet. Theoretical approaches into traceback systems to counter these attacks have been actively researched. However, with no instances of actual application of traceback systems on the Internet, such a response has yet to achieve widespread adoption. This is because multiple autonomous systems (ASs) need to be linked to carry out end-to-end tracking, and this poses a number of issues, including (i) the operational and practical environmental constraints of installing equipment at a variety of Internet Exchange Points (IXPs), (ii) the need to establish operational procedures, and (iii) establishing the monitoring points needed to conduct the traceback. Given these factors, with the aim of achieving the widespread adoption of traceback systems on the Internet in Japan, in this paper we introduce the challenges posed by installing equipment at multiple ASs and report on tracking experiments conducted in response to simulated attacks. Specifically, in terms of (i) environmental constraints, this involved summarizing the size and access restrictions of installed equipment, and in terms of (ii) establishing operational procedures, this involved summarizing the role of operators from the outbreak of an incident to conducting traces and taking countermeasures. Additionally, we investigated the connection status of ASs in Japan to calculate (iii) the number of ASs in which equipment must be installed to satisfy the adoption rate required to carry out tracking.
Synthesis of FeCo Alloy Particles by Modified Polyol Process and their Structural and Magnetic Properties (2006)

In this report, we present the synthesis of FeCo alloy particles with varying composition by using modified polyol process and their magnetic and structural properties are also reported. The morphology, composition, crystal phase and local atomic structures of the magnetic powders were analyzed using XRD, XAFS spectra and SEM. The saturation magnetisation was recorded for FeCo measured under applied field of 15 kOe.
Discriminative tag learning on YouTube videos with latent sub-tags (2011)

We consider the problem of content-based automated tag learning. In particular, we address semantic variations (sub-tags) of the tag. Each video in the training set is assumed to be associated with a sub-tag label, and we treat this sub-tag label as latent information. A latent learning framework based on LogitBoost is proposed, which jointly considers both the tag label and the latent sub-tag label. The latent sub-tag information is exploited in our framework to assist the learning of our end goal, i.e., tag prediction. We use the cowatch information to initialize the learning process. In experiments, we show that the proposed method achieves significantly better results over baselines on a large-scale testing video set which contains about 50 million YouTube videos.