gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Phosphonomethylation of Cyclohexene Oxides. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Figure Legends from Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non–Small Cell Lung Cancer (2023)

&lt;p&gt;Supplementary Figure Legends&lt;/p&gt;
External Beam Radiation to Prevent Restenosis After Superficial Femoral Artery Balloon Angioplasty (2005)

A single session of external beam radiation of 14 Gy of the femoropopliteal angioplasty site significantly reduces restenosis at 1 year.
Rhodium‐Catalyzed Asymmetric Hydrohydrazonemethylation of Styrenes: Access to Chiral Hydrazones, Hydrazides, Hydrazines and Amines (2022)

Abstract The catalytic asymmetric hydroformylation of styrenes was combined with condensation of the resulting aldehydes with acetohydrazide as nucleophile leading to γ‐chiral N’‐substituted aceto‐hydrazones. This cascade reaction is called hydrohydrazonemethylation (HHM) in analogy to similar hydroformylation/condensation sequences. The catalyst was formed in situ from the commercially available chiral phosphine‐ligand ( R , R ) ‐ Ph‐BPE and [Rh(acac)(CO) 2 ] and used at a loading of 0.2 mol%. The stable condensation products are not prone to tautomerization providing versatile chiral intermediates. Their one‐pot reduction with DMAB/TsOH resulted in the corresponding γ‐chiral N’‐substituted acetohydrazides (14 examples) with yields ranging from 73% to 91% and enantioselectivities from 77% to 97% ee . Deprotection of the acetohydrazides led to the corresponding β‐chiral hydrazines. Reduction and hydrogenolysis of the hydrazones over Raney‐Ni yielded the corresponding β‐chiral primary amines with 95% ee . Diastereoselective functionalization of the C=N bond of the hydrazones is a further synthetic option, as demonstrated by allylation with (allyl)SiCl 3 . magnified image
Cobalt‐Embedded Nitrogen‐Rich Carbon Nanotubes Efficiently Catalyze Hydrogen Evolution Reaction at All pH Values (2014)

Despite being technically possible, splitting water to generate hydrogen is still practically unfeasible due mainly to the lack of sustainable and efficient catalysts for the half reactions involved. Herein we report the synthesis of cobalt-embedded nitrogen-rich carbon nanotubes (NRCNTs) that 1) can efficiently electrocatalyze the hydrogen evolution reaction (HER) with activities close to that of Pt and 2) function well under acidic, neutral or basic media alike, allowing them to be coupled with the best available oxygen-evolving catalysts-which also play crucial roles in the overall water-splitting reaction. The materials are synthesized by a simple, easily scalable synthetic route involving thermal treatment of Co(2+) -embedded graphitic carbon nitride derived from inexpensive starting materials (dicyandiamide and CoCl2 ). The materials' efficient catalytic activity is mainly attributed to their nitrogen dopants and concomitant structural defects.
Improved transparency–nonlinearity trade-off with boroxine-based octupolar molecules (2003)

A series of octupolar molecules derived from the boroxine framework were designed and their optical nonlinearities were investigated by performing harmonic light scattering experiments in solution; the molecules were found to combine excellent transparency in the near UV-visible region (lambdamax < or = 280 nm) and significant first-order hyperpolarisabilities (up to beta(0) = 56 x 10(-30) esu).
Guest Editorial: Massive Machine-Type Communications for IoT (2021)

Future wireless cellular networks are envisioned to not only enhance broadband access for human-centric applications, but also offer massive connectivity across tens of billions of devices for machine-centric applications empowered by Internet of Things (IoT) technologies (e.g., smart factory and smart city). To embrace the forthcoming era of IoT, the fifth-generation (5G) cellular communication standard has already identified massive machine-type communications (mMTC) as a key use case in future networks. Contrary to human-type high-speed communications, the focus of IoT communications is on providing connectivity to tens of billions of devices with high energy efficiency, low latency, and high reliability. Consequently, 5G and beyond cellular communication technologies call for radically innovative solutions to support mMTC. Motivated by the crucial role of mMTC in IoT and the dramatically new challenges arising from mMTC as compared to human-type communication, this Feature Topic aims to bring together researchers, industry practitioners, and individuals working on the related areas to share their new ideas, latest findings, and state-of-the-art results.
Supplementary Methods from Steroidogenic Enzyme AKR1C3 Is a Novel Androgen Receptor-Selective Coactivator that Promotes Prostate Cancer Growth (2023)

&lt;p&gt;Supplementary Methods - PDF file 62K, Additional methods to support the manuscript 1. Cloning and protein purification 2. AKR1C3 enzyme activity and thin layer chromatography (TLC)&lt;/p&gt;
The more the better – determining the optimal range when performing single-vesicle phenotyping (2021)

The characterization of extracellular vesicles (EVs) has evolved rapidly in recent years due to advances in straightforward technologies. Based on these more sensitive methods, it is now possible to describe EV populations in their entirety more precisely. However, these applications require an equivalently delicate experiment design and optimization steps to draw valid conclusions in the end. One of these methods is represented by the highly sensitive nanoflow cytometry (nFCM), by which particles can be analyzed not only on their size (&lt; 40 nm) and concentration but also concerning surface markers. In this work, we addressed some of the potential caveats of this method, especially when characterizing particles with fluorescently labelled antibodies. In particular, we show, when using low particle concentrations, which are inevitably encountered when working with EVs, the characterization of surface markers is prone to significantly varying. We hypothesized that these technical limitations could respond to the stickiness of EVs and should be properly counteracted. As a reference, we strongly recommend performing particle number-based comparisons with at least 109 particles as staining input in nFCM analyses. Moreover, we provided representative particle-number based immunoblotting results, underlying the significance of this parameter as a normalizer in future EV research.
Harmonic analysis of SVM and experimental verification in a general purpose induction motor test rig (1994)

This paper focuses primarily on the harmonic analysis of space vector modulation (SVM) line to line voltage waveforms generated using an 80C166 microcontroller. The study is based on practical harmonic measurements of the line to line SVM voltage waveforms using a FFT analyser and simulation results. This paper shows how such an analysis can be used as part of the characterisation of a general purpose 3 phase 7.5 kW induction motor PWM voltage source inverter (VSI) test rig.
Supplementary Figure S2 from EGFR and RB1 as Dual Biomarkers in HPV-Negative Head and Neck Cancer (2023)

&lt;p&gt;Correlation between marker expression intensity and sample collection year. Corr. = correlation coefficient, A.U. = arbitrary unites.&lt;/p&gt;
Heteroleptic Copper Switches (2010)

Heteroleptic copper compounds have been designed and synthesized on solid supports. Chemical redox agents were used to change the oxidation state of the SiO(2)-immobilized heteroleptic copper compounds from Cu(I) to Cu(II) and then back to Cu(I). Optical spectroscopy of a dimethyl sulfoxide suspension demonstrated the reversibility of the Cu(I)/Cu(II) SiO(2)-immobilized compounds by monitoring the metal-to-ligand charge transfer peak at about 450 nm. Electron paramagnetic resonance spectroscopy was used to monitor the isomerization of Cu(I) tetrahedral to Cu(II) square planar. This conformational change corresponds to a 90° rotation of one ligand with respect to the other. Conductive atomic force microscopy and macroscopic gold electrodes were used to study the electrical properties of a p(+) Si-immobilized heteroleptic copper compound where switching between the Cu(I)/Cu(II) states occurred at -0.8 and +2.3 V.
Comparative findings on serum IMg2+of normal and diseased human subjects with the Nova and Kone Ise's for Mg2+ (1994)

It is clear now that although different ionophores for ionized Mg (IMg2+) have been designed by several groups, each of these has a distinctly different KMgCa. In view of this, it is important to determine whether each of these ion selective electrodes (ISE's) yield identical results for IMg2+ in sera from healthy and diseased humans. Using such an approach, we determined, in a blinded-and random manner, IMg2+ with both the NOVA and KONE ISE's for IMg2+ in two independent laboratories. No significant differences were found either for sera from healthy human volunteers or diseased patients. We did, however, note several interesting findings: 1. randomly, selected hospitalized patients exhibit a much higher incidence of abnormalities for IMg2+ (57-71%) than that noted previously for total Mg (TMg) measurements; and 2. coronary heart disease, rectal cancer and multiple sclerosis patients exhibit extracellular deficits in ionized free Mg.
National Trends and Associated Factors of Retropharyngeal Abscess among Adult Inpatients with Peritonsillar Abscess (2014)

Objectives: (1) Describe national trends in retropharyngeal abscess (RPA) complicating peritonsillar abscess (PTA). (2) Determine factors associated with RPA in patients with PTA. Methods: Years 2003 to 2010 of the Nationwide Inpatient Sample (Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality) were queried for PTA (ICD‐9 code: 475) and RPA (ICD‐9 code: 478.24) in adult patients (age ≥18 years old). The cohort was analyzed using descriptive statistics and multivariate regression modeling to identify factors associated with RPA. Results: Of the 90,941 (95% confidence interval [CI]: 86,433‐95,449) patients identified with PTA, 885 (1.0%) also had a concurrently coded RPA. The annual rate of concomitant RPA doubled ( P &lt;. 001) from 0.5% (95% CI: 0.3%‐0.8%) to 1.4% (95% CI: 1.0%‐2.0%) between 2003 and 2010. Patients with RPA were more likely to undergo tonsillectomy (23.5% vs 11.1%) and mechanical ventilation (13.2% vs 2.0%) than those without RPA (all P &lt;. 001). RPA patients were significantly (all P &lt;. 001) older (41 vs 34 years old), had a longer hospital stay (6.4 vs 2.5 days), and had more procedures (2.5 vs 0.9) compared with patients without RPA. Upon multivariate regression analysis, factors associated with RPA included age groups 40 to 64 years (odds ratio [OR] = 2.073, P &lt;. 001), 65 years and older (OR = 2.148, P =. 021), and teaching hospital (OR = 1.838, P &lt;. 001). When controlling for age, sex, and hospital characteristics, general linear modeling demonstrated that RPA accounted for $27,240 ( P &lt;. 001) in excess total charges per patient. Conclusions: The incidence of RPA among adult inpatients with PTA is increasing, and patients with RPA have higher in‐hospital resource utilization. Further studies may help validate factors predictive of RPA to enable earlier identification.
G1 checkpoint protein and p53 abnormalities occur in most invasive transitional cell carcinomas of the urinary bladder (1999)

The G1 cell cycle checkpoint regulates entry into S phase for normal cells. Components of the G1 checkpoint, including retinoblastoma (Rb) protein, cyclin D1 and p16INK4a, are commonly altered in human malignancies, abrogating cell cycle control. Using immunohistochemistry, we examined 79 invasive transitional cell carcinomas of the urinary bladder treated by cystectomy, for loss of Rb or p16INK4a protein and for cyclin D1 overexpression. As p53 is also involved in cell cycle control, its expression was studied as well. Rb protein loss occurred in 23/79 cases (29%); it was inversely correlated with loss of p16INK4a, which occurred in 15/79 cases (19%). One biphenotypic case, with Rb+p16- and Rb-p16+ areas, was identified as well. Cyclin D1 was overexpressed in 21/79 carcinomas (27%), all of which retained Rb protein. Fifty of 79 tumours (63%) showed aberrant accumulation of p53 protein; p53 staining did not correlate with Rb, p16INK4a, or cyclin D1 status. Overall, 70% of bladder carcinomas showed abnormalities in one or more of the intrinsic proteins of the G1 checkpoint (Rb, p16INK4a and cyclin D1). Only 15% of all bladder carcinomas (12/79) showed a normal phenotype for all four proteins. In a multivariate survival analysis, cyclin D1 overexpression was linked to less aggressive disease and relatively favourable outcome. In our series, Rb, p16INK4a and p53 status did not reach statistical significance as prognostic factors. In conclusion, G1 restriction point defects can be identified in the majority of bladder carcinomas. Our findings support the hypothesis that cyclin D1 and p16INK4a can cooperate to dysregulate the cell cycle, but that loss of Rb protein abolishes the G1 checkpoint completely, removing any selective advantage for cells that alter additional cell cycle proteins.
Storage of Human Biospecimens: Selection of the Optimal Storage Temperature (2014)

Millions of biological samples are currently kept at low tempertures in cryobanks/biorepositories for long-term storage. The quality of the biospecimen when thawed, however, is not only determined by processing of the biospecimen but the storage conditions as well. The overall objective of this article is to describe the scientific basis for selecting a storage temperature for a biospecimen based on current scientific understanding. To that end, this article reviews some physical basics of the temperature, nucleation, and ice crystal growth present in biological samples stored at low temperatures (-20°C to -196°C), and our current understanding of the role of temperature on the activity of degradative molecules present in biospecimens. The scientific literature relevant to the stability of specific biomarkers in human fluid, cell, and tissue biospecimens is also summarized for the range of temperatures between -20°C to -196°C. These studies demonstrate the importance of storage temperature on the stability of critical biomarkers for fluid, cell, and tissue biospecimens.
<title>1-megapixel IL-CCD image sensor with a progressive scan, antiblooming control, and lag-free operation</title> (1990)

A 1024 x 1024 pixel, interline charge-coupled device (IL CCD) image sensor has been developed that incorporates antiblooming and electronic exposure control while eliminating lag and obtaining a high responsivity. Of the novel features of this device are its noninterlaced, or progressive-scan architecture and dual-horizontal registers that can be used to clock out the image area by one or two lines at a time. These features make it well suited for applications demanding high-resolution-image capture from a single, high-speed scan.
Distributed Garbage Collection of Active Objects (1990)

This paper shows how to perform distributed automatic garbage collection of objects possessing their own thread of control. The relevance of garbage collection and concurrent objects used in the paper is explained. The collector is comprised of a collection of independent local collectors, one per node, loosely coupled to a distributed global collector. The mutator (application), the local collectors and the global collector run concurrently. The synchronization necessary to achieve correct and efficient concurrent operation between the collectors and the mutator is presented in detail. An interesting aspect of the distributed collector is the termination algorithm: the collector algorithm running on one node, which considers itself to be "done," may become "undone" by the action of a collector algorithm on another node.
A case of disseminated Langerhans cell histiocytosis presenting with necrotizing cervical lymphadenopathy (2018)

Antibiotic-resistant cervical lymphadenopathy can be caused by a wide variety of conditions including genetic, autoimmune, metabolic, and malignant diseases and may thus present a considerable diagnostic challenge.
Light Propagation and Interaction in Highly Scattering Media for Deep Tissue Imaging (2017)

This chapter provides a brief overview of key concepts needed for understanding light propagation deep into a turbid medium, and parameters that are exploited to extract photons that remember initial properties and retain information for generating direct images of targets embedded deep inside the medium. It also provides an overview of the physics of light propagation through highly scattering turbid media, such as microspherical beads suspended in water, Intralipid-10% or similar suspensions, ex vivo tissues from brain, breast, prostate, and other body organs. Linear and nonlinear propagation of optical vortex beams in model turbid media and biological tissues (brain, breast, prostate) are then explored to assess their application in deep imaging application of human body. Ballistic photons are most effective in forming a shadow image. Snake photons also generate transillumination images whose resolution depends on the position and width of the temporal slide used in imaging.
Inexpensive 1024-channel 3D telesonography system on FPGA (2017)

Volumetrie ultrasound (US) is a very promising development of medical US imaging. An under-exploited advantage of volumetric US is the mitigation of the strict probe positioning constrains necessary to acquire 2D scans, potentially allowing the decoupling of US image acquisition and diagnosis. However, today's 3D US systems are large and beset by high power and cost requirements, making them only available in well-equipped hospitals. In this study, we propose the first telesonography-capable medical imaging system that supports up to 1024 channels, on par with the state of the art. As a first embodiment, we have implemented our design in a single development FPGA board of 26.7cm×14cm×0.16cm, with an estimated power consumption of 6.1 W. Moreover, we have equipped our platform with an automatic positioning module to help any operator defining the scan location, hence allowing for better remote diagnosis. Our design supports two types of data inputs: real-time via an optical connection and offline over Ethernet. The reconstructed images can be visualized on an HDMI screen. The estimated cost of the proposed prototype materials is less than 4000€.
Correction: Ruxolitinib sensitizes ovarian cancer to reduced dose Taxol, limits tumor growth and improves survival in immune competent mice (2018)

[This corrects the article DOI: 10.18632/oncotarget.21541.].
Modelling of the ionosphere by neural network for equatorial SBAS (2015)

International audience
Pardaxin, a hydrophobic toxin of the Red Sea flatfish, disassembles the intact membrane of vesicular stomatitis virus. (1981)

Reaction of vesicular stomatitis virus with pardaxin, the hydrophobic toxin of the Red Sea flatfish, resulted in a profound morphological change of many virions and dissociation of their membrane and nucleocapsid into components readily separable by density gradient centrifugation. The basic matrix protein and acidic pardaxin segregated largely with the high density nucleocapsid. The dissociated virion membrane formed lipoprotein vesicles which retained glycoprotein spikes and a certain amount of N protein but no appreciable amounts of other nucleocapsid proteins and little if any RNA. Iodination of the tyrosine residue of the glycoprotein tail fragment provided supporting evidence that the COOH terminus of the glycoprotein extends beyond the inner layer of the membrane into the interior of the virion. These data indicate that pardaxin may serve as a probe for studying the organization of viral membranes, and, hopefully, other biological membranes.
LENS: Layer Distribution Enabled Neural Architecture Search in\n Edge-Cloud Hierarchies (2021)

Edge-Cloud hierarchical systems employing intelligence through Deep Neural\nNetworks (DNNs) endure the dilemma of workload distribution within them.\nPrevious solutions proposed to distribute workloads at runtime according to the\nstate of the surroundings, like the wireless conditions. However, such\nconditions are usually overlooked at design time. This paper addresses this\nissue for DNN architectural design by presenting a novel methodology, LENS,\nwhich administers multi-objective Neural Architecture Search (NAS) for\ntwo-tiered systems, where the performance objectives are refashioned to\nconsider the wireless communication parameters. From our experimental search\nspace, we demonstrate that LENS improves upon the traditional solution's Pareto\nset by 76.47% and 75% with respect to the energy and latency metrics,\nrespectively.\n
Fabrication of TiO2-SiO2 aerogel monolith with ordered mesostructures (2005)

Aerogels prepared by sol-gel and supercritical drying processes possess many unique physical and chemical properties, including large specific surface area and ultralow density with up to 95 % void volume consisting of open and disordered pores of broad size distribution. They also exhibit excellent thermal stability, superior insulating properties and good mechanical strength. Except for silica aerogel, it is difficult to prepare large blocks of freestanding aerogel materials. This work reports a novel synthesis route to create a large blocks of freestanding TiO2-SiO2 aerogels with ordered hierarchical pore structures. The synthesis combined templating method with sol-gel process to create an ordered hexagonal mesoporosity within the alcogel materials. The three dimensional, nanoarchitecture was preserved during subsequent supercritical drying to create ordered mesostructured aerogel blocks. The selection of template molecule, synthesis composition and conditions as well as drying process dictate the pore size of the aerogel (4 to 10 nm). Nanostructured Anatase TiO2 crystals were crystallized in the aerogel matrix and were shown to be active for photocatalytic oxidation of volatile organic molecules.
Changing of the Guard [Notes from the Editor] (2015)

Presents the introductory editorial for this issue of the publication.
AutoMoDe - Model-Based Development of Automotive Software (2007)

This paper describes first results from the AutoMoDe (Automotive Model-Based Development) project. The overall goal of the project is to develop an integrated methodology for model-based development of automotive control software, based on problem-specific design notations with an explicit formal foundation. Based on the existing AutoFOCUS framework, a tool prototype is being developed in order to illustrate and validate the key elements of our approach.
Toward Submicrometer c-Oriented Nanoporous Films with Unidimensional Pore Network: AFI Film Morphology Control by Precursor Mixture Manipulation (2010)

c-Oriented, continuous AlPO4-5 and CoAPO-5 films with an average thickness of as low as 500 nm were synthesized by seeded growth. Growth behavior was controlled by appropriate manipulation of the precursor mixture without altering hydrothermal temperature. Employing crystalline seeds and precrystallization of the precursor mixture under proper conditions yielded a controllable and uniform growth of prism-shaped oriented crystals over the entire substrate surface. Systematically altering the water content affected growth direction, which was continuously tuned between in-plane and c-out-of-plane. The AFI films synthesized by the present work being the first thin, oriented, and well-intergrown ones represent promising materials for fabricating high-flux, unidimensional-pore membranes, for hosting and organizing molecules and clusters, and for growing arrays of monodisperse and ultrathin nanostructures, such as carbon nanotubes, inside the AFI channels targeting highly efficient optoelectronic devices.