gebhart/patrepeval huggingface dataset:
Fruit Morphology, Citrulline, and Arginine Levels in Diverse Watermelon (Citrullus lanatus) Germplasm Collections (2020)

Watermelon (<i>Citrullus lanatus</i>) is a non-seasonal, economically important, cucurbit cultivated throughout the world, with Asia as a continent contributing the most. As part of the effort to diversify watermelon genetic resources in the already cultivated group, this study was devoted to providing baseline data on morphological quality traits and health-beneficial phytonutrients of watermelon germplasm collections, thereby promoting watermelon research and cultivation programs. To this end, we reported morphological traits, citrulline, and arginine levels of watermelon genetic resources obtained from the gene bank of Agrobiodiversity Center, Republic of Korea, and discussed the relationships between each. Diverse characteristics were observed among many of the traits, but most of the genetic resources (>90%) were either red or pink-fleshed. Korean originated fruits contained intermediate levels of soluble solid content (SSC) while the USA, Russian, Tajikistan, Turkmenistan, Taiwan, and Uruguay originated fruits had generally the highest levels of soluble solids. The citrulline and arginine contents determined using the High Performance Liquid Chromatography (HPLC) method ranged from 6.9 to 52.1 mg/g (average, 27.3 mg/g) and 1.8 to 21.3 mg/g (average, 9.8 mg/g), respectively. The citrulline content determined using the Citrulline Assay Kit ranged from 6.5 to 42.8 mg/g (average, 27.0 mg/g). Resources with high citrulline and arginine levels contained low SSC, whereas red- and pink-colored flesh samples had less citrulline compared to yellow and orange.
Data from Delivering Type I Interferon to Dendritic Cells Empowers Tumor Eradication and Immune Combination Treatments (2023)

&lt;div&gt;Abstract&lt;p&gt;An ideal generic cancer immunotherapy should mobilize the immune system to destroy tumor cells without harming healthy cells and remain active in case of recurrence. Furthermore, it should preferably not rely on tumor-specific surface markers, as these are only available in a limited set of malignancies. Despite approval for treatment of various cancers, clinical application of cytokines is still impeded by their multiple toxic side effects. Type I IFN has a long history in the treatment of cancer, but its multifaceted activity pattern and complex side effects prevent its clinical use. Here we develop AcTakines (Activity-on-Target cytokines), optimized (mutated) immunocytokines that are up to 1,000-fold more potent on target cells, allowing specific signaling in selected cell types only. Type I IFN-derived AcTaferon (AFN)-targeting Clec9A&lt;sup&gt;+&lt;/sup&gt; dendritic cells (DC) displayed strong antitumor activity in murine melanoma, breast carcinoma, and lymphoma models and against human lymphoma in humanized mice without any detectable toxic side effects. Combined with immune checkpoint blockade, chemotherapy, or low-dose TNF, complete tumor regression and long-lasting tumor immunity were observed, still without adverse effects. Our findings indicate that DC-targeted AFNs provide a novel class of highly efficient, safe, and broad-spectrum off-the-shelf cancer immunotherapeutics with no need for a tumor marker.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Significance:&lt;/b&gt; Targeted type I interferon elicits powerful antitumor efficacy, similar to wild-type IFN, but without any toxic side effects. &lt;i&gt;Cancer Res; 78(2); 463–74. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Bi-directional single-fiber transmission (2005)

Bi-directional transmission of optical data over a single fiber reduces the first installed cost as well as the operational cost of DWDM systems. This paper discusses the special design issues, when a single amplifier and a single dispersion compensation module are used for both traffic directions. Results of loop transmission experiments over 5000 km of NZDSF are demonstrated.
Oxidation of Water to Dioxygen by Intrazeolitic Ru(bpy)33+ (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidation of Water to Dioxygen by Intrazeolitic Ru(bpy)33+Michael Ledney and Prabir K. DuttaCite this: J. Am. Chem. Soc. 1995, 117, 29, 7687–7695Publication Date (Print):July 1, 1995Publication History Published online1 May 2002Published inissue 1 July 1995https://pubs.acs.org/doi/10.1021/ja00134a013https://doi.org/10.1021/ja00134a013research-articleACS PublicationsRequest reuse permissionsArticle Views582Altmetric-Citations114LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Expanded IR glass map with new NRL glasses for multispectral optics designs (Conference Presentation) (2017)

There is a strong desire to reduce size and weight of single and multiband IR imaging systems in ISR operations on hand-held, helmet mounted or airborne platforms. NRL is working on developing new IR glasses that transmit from 0.9 to > 12 µm in wavelength, with refractive index ranging from 2.38 to 3.17, to expand the glass map and provide compact solutions to multispectral imaging systems. These glasses were specifically designed to have comparable glass molding temperatures and thermal properties so that they can be laminated and co-molded into optics with reduced number of air-glass interfaces (lower Fresnel reflection losses). These new NRL glasses also have negative or very low dn/dT, making it easier to athermalize the optical system. Our multispectral optics designs using these new materials demonstrate reduced size, complexity and improved performance. This presentation will cover discussions on the new optical materials, multispectral designs, as well fabrication and characterization of new optics.
A motif in PSG11s mediates binding to a receptor on the surface of the promonocyte cell line THP-1. (1995)

The pregnancy-specific glycoproteins (PSG) form a large family of essential pregnancy proteins, but their biological function is unknown. We have investigated whether one function of the PSG is to interact with cells of the maternal immune system. Normal human peripheral blood mononuclear cells, activated with phorbol ester, are shown to bind to purified placental PSG. This binding activity can be mimicked using a chemically synthesized peptide ligand containing the Arg-Gly-Asp (RGD) motif present in the N-terminal domain of PSG11s. The PSG11s receptors are present on cells of the myeloid cell lineage but not of the T cell or B cell lineages. The binding is mediated in part by the RGD motif and can be competed against by appropriate RGD-containing, but not Arg-Ala-Asp (RAD)-containing, ligands. Ligand binding requires a functional cytoskeleton. By examining the U937 and THP-1 promonocyte cell lines, the presence of receptors with two different binding characteristics are demonstrated. The THP-1 receptor is identified by chemical cross-linking as a protein of 46 kilodaltons (kDa), and affinity chromatography demonstrates the presence of three protein species of 32 kDa, 16.8 kDa, and 15.9 kDa, suggesting the receptor has multiple subunits.
The adhesion molecule L1 regulates transendothelial migration and trafficking of dendritic cells (2009)

The adhesion molecule L1, which is extensively characterized in the nervous system, is also expressed in dendritic cells (DCs), but its function there has remained elusive. To address this issue, we ablated L1 expression in DCs of conditional knockout mice. L1-deficient DCs were impaired in adhesion to and transmigration through monolayers of either lymphatic or blood vessel endothelial cells, implicating L1 in transendothelial migration of DCs. In agreement with these findings, L1 was expressed in cutaneous DCs that migrated to draining lymph nodes, and its ablation reduced DC trafficking in vivo. Within the skin, L1 was found in Langerhans cells but not in dermal DCs, and L1 deficiency impaired Langerhans cell migration. Under inflammatory conditions, L1 also became expressed in vascular endothelium and enhanced transmigration of DCs, likely through L1 homophilic interactions. Our results implicate L1 in the regulation of DC trafficking and shed light on novel mechanisms underlying transendothelial migration of DCs. These observations might offer novel therapeutic perspectives for the treatment of certain immunological disorders.
Processor subsystem interconnect architecture for a large symmetric multiprocessing system (2004)

Integral to the significant capacity growth of the IBM eServer™ z990 (the eighth-generation zSeries® CMOS-based server) from its predecessor z900 system is the interconnect architecture, which tightly couples 48 customer CPUs in the system. A major attribute of this architecture is a new “hot swap” feature which improves zSeries system availability for customers by permitting the substitution or addition of a field-replaceable unit (FRU) in the processor subsystem without requiring the system to be powered down. The novel two-level interconnect architecture contains a distributed switch which connects up to four processor-memory nodes in book packages. The book packages, which are also FRUs, are connected in a dual concentric ring topology at the second-level (L2) interconnect. This architecture also contains an integrated 32-MB L2 cache and central switch connecting up to eight dual-core processor chips in a star topology at the first-level interconnect inside one of these nodes. This paper describes the bus protocol on the second-level interconnect, the cache coherency management throughout the storage hierarchy, and the ring topology reconfiguration for hot swap. Also described is a memory power management scheme to support the power demand from the 48 CPUs and up to 256 GB of memory.
Synthetic Circularized Analogues of Bovine Pancreatic Trypsin Inhibitor (2004)

Abstract Two cyclic analogues of the protein bovine pancreatic trypsin inhibitor (BPTI), c‐[R] Smc and c‐Cys5[R] Abu , have been synthesized. For the first target, a semisynthetic approach featured a cyclization that took advantage of the constraint imposed by the three disulfides of the native protein. For the second target, an entirely unstructured 58‐residue thiolester, prepared by total synthesis with mild Fmoc chemistry and a side‐chain anchoring strategy, was cyclized by native chemical ligation. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2004)
Quantum Optics with Tin-Vacancy Emitters in Diamond (2019)

We investigate the quantum optical properties of single tin-vacancy emitters in diamond through resonant magneto-optical spectroscopy at 4 K. We find radiative lifetime-limited optical transitions associated with long-lived spin states. © 2019 The Author(s)
Self-Supervised Human Depth Estimation From Monocular Videos (2020)

Previous methods on estimating detailed human depth often require supervised training with ‘ground truth’ depth data. This paper presents a self-supervised method that can be trained on YouTube videos without known depth, which makes training data collection simple and improves the generalization of the learned network. The self-supervised learning is achieved by minimizing a photo-consistency loss, which is evaluated between a video frame and its neighboring frames warped according to the estimated depth and the 3D non-rigid motion of the human body. To solve this non-rigid motion, we first estimate a rough SMPL model at each video frame and compute the non-rigid body motion accordingly, which enables self-supervised learning on estimating the shape details. Experiments demonstrate that our method enjoys better generalization, and performs much better on data in the wild.
Influence of vacuum environment on the aging of phosphors at low electron energies (1999)

Screened samples of two different commercial phosphors were aged at 1.5 keV under nominally identical conditions in five different vacuum systems. After aging to doses of ∼5 C/cm2 the changes in cathodoluminescence (CL) spectral output and photoluminescence properties were determined, and x-ray photoemission spectroscopy (XPS) and Auger analyses were performed. We observed that while the CL degradation was similar for all systems at low electron doses, the aging rates diverged at high doses, suggesting an increasing importance of the vacuum environment. Post-aged CL spectra showed distinct redshifts in all cases, and the most heavily degraded samples displayed XPS-determined increases in surface carbon levels. The data suggest an extrinsic CL aging mechanism; a model involving the conversion of surface hydrocarbons to a metallic graphite phase agrees with the data.
Sprayed Water Microdroplets Are Able to Generate Hydrogen Peroxide Spontaneously (2022)

Ultrapure N<sub>2</sub> gas was bubbled through water, and the humidified output containing undetectable concentrations of ozone filled a closed chamber in which 18 MΩ-cm water was sprayed through a silica capillary to form microdroplets. Analysis of the collected microdroplets by NMR spectroscopy showed the presence of hydrogen peroxide at a concentration level ranging from 0.3 to 1.5 μM depending on the flow conditions. This was confirmed using a spectrofluorometric assay. We suggest that this finding establishes that when sprayed to form microdroplets, water has the ability to produce hydrogen peroxide by itself. When the N<sub>2</sub> gas is replaced by compressed air or O<sub>2</sub> gas, the concentration of hydrogen peroxide is found to increase, indicating that gas-surface interactions with O<sub>2</sub> in aqueous microdroplets promote the formation of hydrogen peroxide.
Vertical defects in heavily Mg‐doped Al0.69Ga0.31N (2007)

Abstract The microstructure of p‐type Al 0.69 Ga 0.31 N with high Mg‐doping was studied by conventional transmission electron microscopy (TEM) and scanning transmission electron microscopy (STEM). Spike‐like domains were observed with an average diameter of ∼10 nm, height of ∼400 nm and density of 2.2 × 10 11 /cm 2 . These long and narrow domains nucleated about 200 nm above the Mg‐doping boundary and resembled ordinary inversion domains induced by Mg‐doping. However, the energy dispersive X‐ray spectroscopy line‐scan results provided unambiguous evidence that the domains were Ga‐rich. The lateral composition segregation between the domains and surrounded matrix was further confirmed by high angular dark field images in STEM. (© 2007 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Flow-Induced Reactive Self-Assembly (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorFlow-Induced Reactive Self-AssemblyCharles A. Orr, Adeyinka Adedeji, Akira Hirao, Frank S. Bates, and Christopher W. MacoskoView Author Information Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, and Department of Polymer Chemistry, Tokyo Institute of Technology, Tokyo 152, Japan Cite this: Macromolecules 1997, 30, 4, 1243–1246Publication Date (Web):February 24, 1997Publication History Received23 October 1996Revised19 December 1996Published online24 February 1997Published inissue 1 February 1997https://pubs.acs.org/doi/10.1021/ma961574khttps://doi.org/10.1021/ma961574krapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views604Altmetric-Citations78LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Amines,Aromatic compounds,Copolymers,Hydrocarbons,Interfaces Get e-Alerts
ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury (2021)

Abstract Angiotensin-converting enzyme 2 (ACE2) is a receptor for cell entry of SARS-CoV-2, and recombinant soluble ACE2 protein inhibits SARS-CoV-2 infection as a decoy. ACE2 is a carboxypeptidase that degrades angiotensin II (Ang II) to angiotensin 1-7 (Ang 1-7) and thereby improves the pathologies of cardiovascular disease or acute lung injury. To address whether the carboxypeptidase activity of ACE2 is protective in COVID-19, we investigated the effects of B38-CAP, an ACE2-like enzyme, on SARS-CoV-2-induced lung injury. Expression of endogenous ACE2 protein was significantly downregulated in the lungs of SARS-CoV-2-infected hamsters or SARS-CoV-2 challenged human ACE2 transgenic mice, leading to elevation of Ang II levels. In vivo administration of recombinant SARS-CoV-2 Spike also downregulated ACE2 expression, elevated Ang II levels and considerably worsened the symptoms of acute lung injury in hamsters exposed to acid aspiration. Despite its ACE2-like catalytic core, B38-CAP neither bound to Spike nor neutralized cell entry of SARS-CoV-2. However, treatment with B38-CAP improved the pathologies of Spike-augmented acid-induced lung injury. In SARS-CoV-2-infected hamsters, B38-CAP significantly improved lung edema and pathologies of lung injury and downregulated IL-6 levels without affecting viral RNA loads. Moreover, in human ACE2 transgenic mice, B38-CAP also attenuated SARS-CoV-2-induced lung edema and pathologies and improved lung functions. These results provide the first experimental in vivo evidence that increasing ACE2-like enzymatic activity is a potential therapeutic strategy to alleviate lung pathologies in COVID-19.
Potential profile measurements using a collimated proton detector in spherical inertial-electrostatic plasma confinement (1992)

A collimated proton detector has been developed for spatial resolved proton measurements in inertial-electrostatic plasma confinement (IEC) fusion experiments. These are the first proton measurements used to infer potential well profiles on an IEC device. This paper describes a new technique for investigating the existence of multiple potential wells inside IEC devices. Analysis of the observed proton energy and source profile indicates that (for a 12-mA cathode current, a 30-kV cathode voltage in a 4-mTorr D2 background) predominantly beam-background fusion occurs. Computer simulation suggests that a positive space charge potential approximately half that of the applied voltage is formed inside the cathode. These results establish the first measurement of a positive potential well structure inside an ion-injected IEC device.
Water Flow Measurement for Swimmers using Artificial Food-grade Roe as Tracer Particles (2019)

Water flow is strongly related to swimming speed; thus, technologies for measuring the three-dimensional movement of water are highly desired in the water sports industry. However, existing fluid measurement methods are not suitable for use with humans because they introduce tiny plastic particles (known as tracer particles) that contain fluorescent ink, which is used to visualize water flow. A laser then irradiates the environment to make the particles brighter than the surroundings to track their movement with cameras. This method has potential adverse effects to humans, such as accidental swallowing of the particles and laser burns to the skin and eyes. In this research, we propose a human-friendly water flow measuring technology using tracer particles made of food-grade materials and a harmless light source. To visualize tracer particles, we give the particles an optical property, which makes them sufficiently brighter than the surroundings when placed between circularly polarized plates. We tested the proposed setup for water flow measurement in an actual swimming environment with swimmers. We observed that tracer particles moved in accordance with the water flow caused by a swimming stroke.
Video Segmentation-aided VCR Support for P2P VoD Systems (2008)

VCR functionality is difficult to be implemented in a P2P VoD system, since it may give more server workload and fails some distribution paths. In this paper, we first analyze the user behavior of VCR interaction, and propose a video segmentation-aided P2P VoD System with VCR functionality. The simulation results show that our mechanism could reduce the server workload and improve the VCR performance at end hosts.
Reactivation of Viruses in Solid Organ Transplant Patients Receiving Cytomegalovirus Prophylaxis (2006)

A series of substudies of a large international cytomegalovirus (CMV) prophylaxis trial investigated the incidence and clinical relevance of reactivation of human herpesviruses 6, 7, and 8, varicella zoster virus, Epstein-Barr virus, polyomavirus, and adenovirus, and the effect of CMV prophylaxis on clinical and subclinical non-CMV viral infections, in adult solid organ transplant (SOT) patients. Results of the substudy analyses showed that viremia caused by a number of viruses is surprisingly common posttransplantation; most of these infections likely represent reactivation of endogenous latent virus. In addition, although infection or active viral replication was common in this cohort of SOT patients, symptomatic disease due to these viruses was uncommon and the clinical sequelae of viremia were unclear or not apparent. CMV prophylaxis may have modified the natural history of some of these non-CMV viral infections.