gebhart/patrepeval huggingface dataset:
Magnetic properties and microstructures of the Nd-Fe-B system during the hydrogenation-decomposition-desorption-recombination process (1993)

The Nd-Fe-B and Nd-Fe-Co-B magnet powders with the high coercivity (≥10 kOe) were obtained by the hydrogenation-decomposition-desorption-recombination (HDDR) process at temperatures between 800 °C and 900 °C. We studied magnetic properties and microstructures of the Nd-Fe-B systems during the HDDR process. The NdH2 phase produced by decomposition of Nd2Fe14BHx with hydrogenation exists in the maze-like form of the size of 10−1 μm. It was found that the size of the NdH2 phase determines the size of the Nd2Fe14B phase formed by the recombination. NdH2, Fe, and Fe2B are more stable than Nd2Fe14B at temperatures from 800 °C to 900 °C. The magnet powders produced by the HDDR process are magnetically almost isotropic.
ChemInform Abstract: Laser Flash Photolysis Study of Adamantanylidene. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Faraday anomalous dispersion optical filters (1992)

Common methods for frequency stabilizing diode lasers systems employ gratings, etalons, optical electric double feedback, atomic resonance, and a Faraday cell with low magnetic field. Our method, the Faraday Anomalous Dispersion Optical Transmitter (FADOT) laser locking, is much simpler than other schemes. The FADOT uses commercial laser diodes with no antireflection coatings, an atomic Faraday cell with a single polarizer, and an output coupler to form a compound cavity. This method is vibration insensitive, thermal expansion effects are minimal, and the system has a frequency pull in range of 443.2 GHz (9A). Our technique is based on the Faraday anomalous dispersion optical filter. This method has potential applications in optical communication, remote sensing, and pumping laser excited optical filters. We present the first theoretical model for the FADOT and compare the calculations to our experimental results.
Development of a Bioassay System for the Predator, Xylocoris flavipes (Heteroptera: Anthocoridae), and Its Use in Subchronic Toxicity/Pathogenicity Studies of Beauveria bassiana Strain GHA (2003)

Microbial biocontrol agents are useful commercially only if they do not harm other natural biocontrol organisms, at recommended use rate in the environment where the microorganism is being used. To test the hypothesis that the predatory warehouse pirate bug, Xylocoris flavipes (Reuter), is not adversely affected by the entomopathogen, Beauveria bassiana (Balsamo) Vuillemin strain GHA, we developed a method using individually confined bugs during a 10-d feeding regime. Three concentrations of a conidial suspension were applied to assay surfaces (filter paper disks) to achieve 2.7 x 10(7), 2.6 x 10(6), and 2.6 x 10(5) conidia per cm2, representing 100X, 10X, and a field rate of 2.6 x 10(13) conidia per ha (+/-10%), respectively. Fifth instar X. flavipes suffered 0% infection at the field rate when confined to treated filter paper for 10 d (16% and 42% infection, respectively, at 10X and 100X the field rate). Second instar migratory grasshoppers, Melanoplus sanguinipes (F.), exposed to the same doses suffered 97, 92, and 100% mortality at the three respective doses 10 d after exposure. These data indicate that B. bassiana can be used safely at recommended application levels without significant effect on fifth instar populations of X. flavipes.
The Geometrical And Dynamical Behaviour Of Ultraprecision Diamond Turning Machines Set Limits To The Workpiece Accuracy (1989)

The influences of straightness errors and machine resonances on the surface of faced mirrors are discussed. Measurement results of the machine behaviour are compared with the surface shapes and micro-structure of produced workpieces. A correlation between the measurement results of the machine and the analysed workpiece surfaces is presented in this paper.
Hyperlipofuscinosis With Subretinal Fibrosis and Choroidal Vascular Remodeling in Stargardt Disease (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Ophthalmology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Ophthalmology journal
Common-Mode Voltage Investigation and Reduction of Split-Source Inverter (2018)

Common mode voltage (CMV), produced by conventional high-frequency pulsewidth modulated (PWM) voltage source inverters (VSIs), is a major area of interest in applications such as transformerless Photovoltaic (PV) systems, electric motor drives, as well as grid-connected inverters. Since the VSI can only be utilized as a buck inverter, the AC output voltage should be boosted up using an extra boosting stage either in the DC side or in the AC side. So, to reduce the cost, complexity, size, and weight of the converter, the additional boosting stage must be eliminated by using single-stage DC-AC converters, which have the buck-boost feature in a single stage. This paper investigates the induced CMV issue due to a recent single-stage DC-AC inverter topology, split-source inverter (SSI), which has not been comprehensively examined. The CMV waveforms for both VSI and SSI have been analyzed and compared. Furthermore, the paper proposes a discontinuous PWM (DPWM) to alleviate the CMV effect. To check the validity of the proposed analysis, simulations were done using MATLAB/Simulink model. It was shown that a significant CMV reduction could be achieved using the proposed modulation technique.
Regioselective synthesis, antimicrobial evaluation and theoretical studies of 2-styryl quinolines (2014)

2-Styryl quinolines (9a-l) have been synthesized regioselectively from 2-methyl-quinoline by using NaOAc in water acetic acid binary solvents and evaluated for their antibacterial activity against both Gram-positive and Gram-negative strains. Among these, the compounds 12 and 8 were found to be active against both bacterial strains. Compounds 9b, 9f, 9g, 9i, 9j and 9k were the most active among the series exhibiting MIC values ranging between 1.9 and 31.2 μg ml(-1) against different bacterial strains. Compounds 9j and 9k were found to be as potent as the standard drug ciprofloxacin against Micrococcus luteus, Klebsiella planticola and Staphylococcus aureus. In addition, the compounds showed bactericidal activity; compound 9j was found to be better than ciprofloxacin, with an MBC value of 0.9 μg ml(-1) against both M. luteus and K. planticola. The compounds also inhibited biofilm formation, and compound 9j was found to be equipotent to erythromycin against M. luteus and S. aureus MLS16. Further, theoretical studies such as those on druggable properties and PMI plot have been carried out.
H6 Influenza Viruses Pose a Potential Threat to Human Health (2014)

Avian influenza viruses continue to present a challenge to human health. Research and pandemic preparedness have largely focused on the H5 and H7 subtype influenza viruses in recent years. Influenza viruses of the H6 subtype have been isolated from wild and domestic aquatic and terrestrial avian species throughout the world since their first detection in the United States in 1965. Since 1997, H6 viruses have been detected frequently in the live poultry markets of southern China; however, the biological characterization of these viruses is very limited. Here, we assessed the receptor-binding preference, replication, and transmissibility in mammals of a series of H6 viruses isolated from live poultry markets in southern China and found that 34% of the viruses are able to bind human type receptors and that some of them are able to transmit efficiently to contact animals. Our study demonstrates that the H6 viruses pose a clear threat to human health.
Degradation mechanisms of 2 MeV proton irradiated AlGaN/GaN HEMTs (2015)

Proton-induced damage in AlGaN/GaN HEMTs was investigated using energy-dispersive X-ray spectroscopy (EDS) and transmission electron microscopy (TEM), and simulated using a Monte Carlo technique. The results were correlated to electrical degradation using Hall measurements. It was determined by EDS that the interface between GaN and AlGaN in the irradiated HEMT was broadened by 2.2 nm, as estimated by the width of the Al EDS signal compared to the as-grown interface. The simulation results show a similar Al broadening effect. The extent of interfacial roughening was examined using high resolution TEM. At a 2 MeV proton fluence of 6 × 1014 H+/cm2, the electrical effects associated with the Al broadening and surface roughening include a degradation of the ON-resistance and a decrease in the electron mobility and 2DEG sheet carrier density by 28.9% and 12.1%, respectively.
Multipath Diversity through Time Shifted Sampling for Spatially Correlated OFDM-Antenna Array Systems (2008)

An essential condition for diversity reception is that the fading distributions between the individual received signals of an antenna array are uncorrelated. In this paper, a new technique to improve the performance of transmission with the correlated Rayleigh-fading signals is proposed. In conventional array systems, individual receivers start sampling the received signals at the same time with the same sampling rate. On the other hand, in the proposed scheme, the received signals are again sampled with the same rate, however the sampling points are shifted in each receiver. Numerical results through computer simulation show that with the correlated received signals, by applying the proposed technique the correlation can be reduced to a sufficient level for diversity reception.
Abstract 3420: Discovery of genetic alterations governing sinonasal squamous cell carcinoma tumorigenesis (2018)

Abstract Tumors of the sinonasal tract are uncommon, and comprise 5% of all cancers of the head and neck (H&amp;N). Approximately 50-80% of sinonasal malignancies are sinonasal squamous cell carcinoma (SNSCC). Unlike H&amp;N cancers, tobacco smoking does not seem to play a key role in the development of sinonasal tumors and the exact etiology and molecular mutations governing SNSCC tumorigenesis are not well understood. Inverted sinonasal papilloma (ISP) is a locally aggressive, benign epithelial neoplasm arising in the paranasal sinuses which has a high recurrence rate and transforms to SNSCC in 10% to 25% of cases, and therefore represent an intermediate step in SNSCC progression. Due to its uncommon nature, there is still a significant knowledge gap in our understanding of SNSCC pathogenesis and genetic mutations associated with SNSCC progression have not yet been characterized. To this end, we performed whole exome sequencing (WES) and RNA-Seq on 4 ISPs and matched SCCs samples collected from the same patients. For each patient, DNA extracted from matched lymphocytes was used as a DNA sequencing control, whereas matched uninvolved mucosa was used as a tissue specific control for RNA-Seq. 285 and 602 non-synonymous aberrations were identified across the preneoplastic lesions and tumors respectively. Interestingly, genes associated with adverse survival in HNSCC patients (such as EGFR, FAT1 and IGF1R) were mutated in more than 1 dysplastic lesion. PIK3CA was among the most mutated genes in invasive neoplasms. Notably, in three patients we identified mutations that were present in both preneoplastic and invasive neoplasms, which included cancer driver genes actionable in HNSCC and other solid malignancies (such as PIK3CA, TP53, FAT1 and EGFR). RNA-Seq analysis of the same samples revealed a subset of genes whose expression level sequentially increased or decreased from normal tissue, to early lesions to SNSCC. Interestingly, expression of genes associated with survival, migration, invasiveness and inhibition of apoptosis (such as SET, RAD21, NPM1, PTPN11, CLIP1, KIF5B, EGFR, NRAS, KRAS, MET, MYCL and CCND1) consecutively increased along the tumor progression in all three analyzed, whereas expression of tumor suppressors (such as PTCH1, IKZF1, GAS7, FOXP1, NTRK3 and LRP1B) was downregulated. Although our data suggest that preneoplastic ISP lesions may be clonally related to SCC in some cases, validation of these observations in a larger specimens' cohort is warranted to further delineate the mechanisms underlying the SNSCC tumorigenesis. Citation Format: Adrian D. Schubert, Nyall R. London, Justin A. Bishop, Esther C. Broner, David Sidransky, Evgeny Izumchenko. Discovery of genetic alterations governing sinonasal squamous cell carcinoma tumorigenesis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 3420.
ChemInform Abstract: Small Molecules that Modulate Quorum Sensing and Control Virulence in Pseudomonas aeruginosa. (2010)

Abstract Review: 98 refs.
A Novel Mutation in the Upstream Open Reading Frame of the CDKN1B Gene Causes a MEN4 Phenotype (2013)

The CDKN1B gene encodes the cyclin-dependent kinase inhibitor p27(KIP1), an atypical tumor suppressor playing a key role in cell cycle regulation, cell proliferation, and differentiation. Impaired p27(KIP1) expression and/or localization are often observed in tumor cells, further confirming its central role in regulating the cell cycle. Recently, germline mutations in CDKN1B have been associated with the inherited multiple endocrine neoplasia syndrome type 4, an autosomal dominant syndrome characterized by varying combinations of tumors affecting at least two endocrine organs. In this study we identified a 4-bp deletion in a highly conserved regulatory upstream ORF (uORF) in the 5'UTR of the CDKN1B gene in a patient with a pituitary adenoma and a well-differentiated pancreatic neoplasm. This deletion causes the shift of the uORF termination codon with the consequent lengthening of the uORF-encoded peptide and the drastic shortening of the intercistronic space. Our data on the immunohistochemical analysis of the patient's pancreatic lesion, functional studies based on dual-luciferase assays, site-directed mutagenesis, and on polysome profiling show a negative influence of this deletion on the translation reinitiation at the CDKN1B starting site, with a consequent reduction in p27(KIP1) expression. Our findings demonstrate that, in addition to the previously described mechanisms leading to reduced p27(KIP1) activity, such as degradation via the ubiquitin/proteasome pathway or non-covalent sequestration, p27(KIP1) activity can also be modulated by an uORF and mutations affecting uORF could change p27(KIP1) expression. This study adds the CDKN1B gene to the short list of genes for which mutations that either create, delete, or severely modify their regulatory uORFs have been associated with human diseases.
<title>Template selection and rejection for robust nonrigid 3D registration in the presence of large deformations</title> (2001)

The purpose of the proposed template propagation method is to support the comparative analysis of image pairs even when large deformations (e.g. from movement) are present. Starting from a position where valid starting estimates are known, small sub-volumes (templates) are registered rigidly. Propagating registration results to neighboring templates, the algorithm proceeds layer by layer until corresponding points for the whole volume are available. Template classification is important for defining the templates to be registered, for propagating registration results and for selecting successfully registered templates which finally represent the motion vector field. This contribution discusses a template selection and classification strategy based on the analysis of the similarity measure in the vicinity of the optimum. For testing the template propagation and classification methods, deformation fields of four volume pairs exhibiting considerable deformations have been estimated and the results have been compared to corresponding points picked by an expert. In all four cases, the proposed classification scheme was successful. Based on homologous points resulting from template propagation, an elastic transformation was performed.
Supplementary Figure 4 from Selective Targeting of Interferon γ to Stromal Fibroblasts and Pericytes as a Novel Therapeutic Approach to Inhibit Angiogenesis and Tumor Growth (2023)

&lt;p&gt;PDF file, 221K, Body weight of mice after the treatment with PBS, IFNγ, pPB-HSA-IFNγ and pPB-HSA in B16 tumor-bearing mice.&lt;/p&gt;
Immunological tailoring of monoclonal antibodies for immunotherapy of pancreatic carcinoma (1988)

Spontaneous isotype switch variants from IgG1 to IgG2a of monoclonal antibody (MAb) BW 494 were generated. Their frequency was found to be 1 variant cell out of 2 X 10(5) parental hybrid cells. The tissue specificity of the parental MAb BW 494 IgG1 was identical to that of the BW 494 IgG2a variant arguing for an unaltered paratope shared by the parent and the variant. In contrast, the switch in isotype from IgG1 to IgG2a resulted in an increase of the variant potential to mediate antibody dependent cellular cytotoxicity (ADCC) reaction with human peripheral blood mononuclear cells as effectors. The potential of variants to perform human complement mediated cytolysis (CDC) was not better than that of the parental MAb.
Fragment-based covalent ligand discovery (2021)

Covalent fragment-based ligand discovery greatly facilitates the discovery of useful fragments for drug discovery and helps unveil chemical-tractable biological targets in native biological systems.
Lutein Enhances Bone Mass by Stimulating Bone Formation and Suppressing Bone Resorption in Growing Mice (2017)

Lutein is a member of the xanthophyll family of carotenoids, which are known to prevent hypoxia-induced cell damage in the eye by removing free radicals. However, its role in other tissues is controversial, and the effects of lutein on bone tissues are unknown. To identify a possible role of lutein in bone tissues, we examined the effects of lutein on bone formation and bone resorption and on femoral bone mass in mice. Lutein enhanced the formation of mineralized bone nodules in cultures of osteoblasts. On the other hand, lutein clearly suppressed 1α, 25-dihydroxyvitamin D<sub>3</sub>-induced bone resorption as measured by pit formation in organ culture of mouse calvaria. In co-cultures of bone marrow cells and osteoblasts, lutein suppressed 1α, 25-dihydroxyvitamin D<sub>3</sub>-induced osteoclast formation. In cultures of bone marrow macrophages, lutein suppressed soluble RANKL, the receptor activator of nuclear factor-kappaB (NF-κB) ligand, induced osteoclast formation. When five-week-old male mice were orally administered lutein for 4 weeks, the femoral bone mass was clearly enhanced in cortical bone, as measured by bone mineral density in dual X-ray absorptiometry and micro computed tomography (µCT) analyses. The present study indicates that lutein enhances bone mass in growing mice by suppressing bone resorption and stimulating bone formation. Lutein may be a natural agent that promotes bone turnover and may be beneficial for bone health in humans.
The post-translational proteolysis of the subunits of vicilin from pea (Pisum sativum L.) (1982)

Tryptic-peptide profiles and amino acid sequencing of purified pea (Pisum sativum L.) vicilin subunits were used to show that their sequences were interrelated. Comparison with the nucleotide sequence of a cloned vicilin complementary DNA (mRNA) showed that all vicilin subunits could be derived from 50 000-Mr precursors containing up to two sites for post-translational proteolytic cleavage, and allowed these subunits to be located relative to the precursor.
Locked Plating Versus Spiral Blade Retrograde Nailing in Supracondylar Femoral Fractures (2012)

Comminuted supracondylar femur fractures in the elderly are often treated with either retrograde femoral nailing or locked plating. Early weight-bearing is typically restricted after fixing supracondylar fractures, thereby impairing the patient’s mobilization. In general, surgeons are more comfortable allowing early weight-bearing of long bone fractures after nailing rather than plating, but early studies of retrograde nails for supracondylar fractures using standard distal locking showed poor fixation compared with locked plating.
Racetrack SAFER barrier on temporary concrete barriers (2013)

Previously, the Steel and Foam Energy Reduction (SAFER) barrier system was successfully developed and crash tested for use in high-speed racetrack applications for the purpose of reducing the severity of racecar crashes into permanent, rigid, concrete containment walls. The SAFER barrier has been implemented at all high-speed oval race tracks that host events from NASCAR's top three race series and IRL's top series. However, there are a number of racetrack facilities in the United States that use temporary concrete barriers as a portion of the track layout during races. These barriers are typically used on race tracks to shield openings or protect portions of the infield. Some of these temporary barrier installations are in areas where current safety guidance would recommend treatment with the SAFER barrier. Thus, a system was successfully designed, tested, and evaluated for a system targeted towards the most pressing need in the US motorsports industry, a system for spanning openings between rigid concrete parapets on the inner walls of various race tracks.