gebhart/patrepeval huggingface dataset:
Phosphorylation of the ATP-sensitive, Inwardly Rectifying K+ Channel, ROMK, by Cyclic AMP-dependent Protein Kinase (1996)

Activity of the recently cloned ATP-sensitive epithelial K+ channel, ROMK (Ho, K., Nichols, C. G., Lederer, W. J., Lytton, J., Vassilev, P. M., Kanazirska, M. V., and Hebert, S. C. (1993) Nature 362, 31-38), is regulated by phosphorylation-dephosphorylation processes with cAMP-dependent protein kinase (PKA)-dependent phosphorylation events being required for maintenance of channel activity in excised membrane patches (McNicholas, C. M., Wang, W., Ho, K., Hebert, S. C., and Giebisch, G. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 8077-8081; Kubokawa, M., McNicholas, C. M., Higgins, M. A., Wang, W., and Giebisch, G. (1995) Am. J. Physiol. 269, F355-F362). To determine whether this channel is a substrate for PKA, ROMK tagged with the hemagglutinin epitope was transiently transfected into HEK293 cells. In vitro labeling of immunoprecipitated proteins from transfected cells showed that ROMK could be phosphorylated by PKA. Metabolic labeling of ROMK resulted in a significantly increased phosphorylation upon pretreatment of the cells with forskolin, consistent with an action of cAMP-dependent protein kinase. Phosphoamino acid analyses of the ROMK phosphoproteins revealed that phosphate was attached exclusively to serine residues. Three putative PKA phosphorylation sites containing serine residues in the predicted ROMK proteins are shown directly to be substrates for PKA. Site-directed mutagenesis of each of these sites or double mutation of any two sites showed that ROMK proteins retained the ability to be phosphorylated by PKA both in vivo and in vitro to a variable extent, while triple mutation of all three PKA sites abolished the phosphorylation induced by cAMP agonists in transfected cells. Two-electrode voltage clamp experiments showed that PKA-dependent phosphorylation was required for ROMK channel activity and that at least two of the three sites were required for channel function when expressed in X. laevis oocytes. Taken together, these results provide strong evidence that direct phosphorylation of the channel polypeptide by PKA is involved in channel regulation and PKA-dependent phosphorylation is essential for ROMK channel activity.
Compressed text indexes (2009)

A compressed full-text self-index represents a text in a compressed form and still answers queries efficiently. This represents a significant advancement over the (full-)text indexing techniques of the previous decade, whose indexes required several times the size of the text. Although it is relatively new, this algorithmic technology has matured up to a point where theoretical research is giving way to practical developments. Nonetheless this requires significant programming skills, a deep engineering effort, and a strong algorithmic background to dig into the research results. To date only isolated implementations and focused comparisons of compressed indexes have been reported, and they missed a common API, which prevented their re-use or deployment within other applications. The goal of this article is to fill this gap. First, we present the existing implementations of compressed indexes from a practitioner's point of view. Second, we introduce the Pizza&amp;Chili site, which offers tuned implementations and a standardized API for the most successful compressed full-text self-indexes, together with effective test-beds and scripts for their automatic validation and test. Third, we show the results of our extensive experiments on these codes with the aim of demonstrating the practical relevance of this novel algorithmic technology.
Analysis of The GLONASS And GPS Signals Availability At The GEO. (2004)

The objective of this paper is to analyze possibilities that create complete GLONASS and GPS constellations in terms of simultaneous reception of several navigation signals in the geostationary Earth orbit (GEO). In the paper an empirical analysis is done on how many GLONASS and GPS signals can be tracked simultaneously. The result of the analysis is that up to 2 GLONASS and up to 3 GPS satellites can be tracked at the same time. These results are proved with simulation. Also simulation has shown that combined application of GLONASS and GPS significantly improves overall signal availability. Compared with GPS alone combined usage of GLONASS and GPS increases signal availability by a factor of 2 through 4. The simulation results are presented in graphs depicting probability of simultaneous signal tracking from several NSV, and in tables demonstrating average and maximum duration of observability intervals.
A multi‐compartment mitochondrial model of brain metabolism shows that network topology supports theories in neurochemistry (2008)

We present a network reconstruction of brain mitochondria metabolism built using mass‐spectrometric data, gene expression data, and an extensive literature search to fill in network gaps, determine reaction directionality and to curate reaction presence and properties. Reactions were further parsed into cellular compartments allowing for view of metabolite transfer between cell types. Using constraint based methods to analyze the model, we demonstrate that application of known constraints leads to a network topology that supports experimental results of brain energetics, and theories involving glutamate recycling and the astrocyte‐neuron lactate shuttle. This demonstrates the ability of constraint based methods to predict biological function in systems biology. Funded by NIH Training Grant HL‐07089
Risk Minimization from Adaptively Collected Data: Guarantees for Supervised and Policy Learning (2021)

Empirical risk minimization (ERM) is the workhorse of machine learning, whether for classification and regression or for off-policy policy learning, but its model-agnostic guarantees can fail when we use adaptively collected data, such as the result of running a contextual bandit algorithm. We study a generic importance sampling weighted ERM algorithm for using adaptively collected data to minimize the average of a loss function over a hypothesis class and provide first-of-their-kind generalization guarantees and fast convergence rates. Our results are based on a new maximal inequality that carefully leverages the importance sampling structure to obtain rates with the right dependence on the exploration rate in the data. For regression, we provide fast rates that leverage the strong convexity of squared-error loss. For policy learning, we provide rate-optimal regret guarantees that close an open gap in the existing literature whenever exploration decays to zero, as is the case for bandit-collected data. An empirical investigation validates our theory.
Draft Genome Sequence of Streptomyces sp. TP-A0356, a Producer of Yatakemycin (2015)

Here, we report the draft genome sequence of Streptomyces sp. TP-A0356, a producer of a potent antitumor antibiotic, yatakemycin, to evaluate potential for secondary metabolite production. The genome sequence data suggest the presence of at least nine gene clusters for polyketide synthases and nonribosomal peptide synthetases in this strain.
In Situ Neutron Depth Profiling of Lithium Metal–Garnet Interfaces for Solid State Batteries (2017)

The garnet-based solid state electrolyte (SSE) is considered a promising candidate to realize all solid state lithium (Li) metal batteries. However, critical issues require additional investigation before practical applications become possible, among which high interfacial impedance and low interfacial stability remain the most challenging. In this work, neutron depth profiling (NDP), a nondestructive and uniquely Li-sensitive technique, has been used to reveal the interfacial behavior of garnet SSE in contact with metallic Li through in situ monitoring of Li plating-stripping processes. The NDP measurement demonstrates predictive capabilities for diagnosing short-circuits in solid state batteries. Two types of cells, symmetric Li/garnet/Li (LGL) cells and asymmetric Li/garnet/carbon-nanotubes (LGC), are fabricated to emulate the behavior of Li metal and Li-free Li metal anodes, respectively. The data imply the limitation of Li-free Li metal anode in forming reliable interfacial contacts, and strategies of excessive Li and better interfacial engineering need to be investigated.
Model validation for dynamically uncertain systems (1997)

Robust control models describe system uncertainty with both unknown additive signals and unknown dynamic perturbations. These unknown but bounded components lead to a model set description. Model validation is the experimental assessment of the ability of this model set to describe the observed system behaviors. In this paper we consider model validation for H∞ compatible models. This paper provides a detailed presentation of the H∞ model validation problem in the discrete frequency, discrete-time, and sampled-data frameworks. In each case the underlying results and the computational algorithms are discussed. The experimental applicability and the computational consequences are discussed in sufficient detail to give the reader an appreciation of the issues surrounding each model/experiment framework.
Development of an Electrochemical Separator and Compressor (2011)

Global conversion to sustainable energy is likely to result in a hydrogen-based economy that supports U.S. energy security objectives while simultaneously avoiding harmful carbon emissions. A key hurdle to successful implementation of a hydrogen economy is the low-cost generation, storage, and distribution of hydrogen. One of the most difficult requirements of this transformation is achieving economical, high density hydrogen storage in passenger vehicles. Transportation applications may require compression and storage of high purity hydrogen up to 12,000 psi. Hydrogen production choices range from centralized low-pressure generation of relatively impure gas in large quantities from steam-methane reformer plants to distributed generation of hydrogen under moderate pressure using water electrolysis. The Electrochemical Hydrogen Separator + Compressor (EHS+C) technology separates hydrogen from impurities and then compresses it to high pressure without any moving parts. The Phase I effort resulted in the construction and demonstration of a laboratory-scale hardware that can separate and compress hydrogen from reformate streams. The completion of Phase I has demonstrated at the laboratory scale the efficient separation and compression of hydrogen in a cost effective manner. This was achieved by optimizing the design of the Electrochemical Hydrogen Compression (EHC) cell hardware and verified by parametric testing in single cell hardware. A broad range of commercial applications exist for reclamation of hydrogen. One use this technology would be in combination with commercial fuel cells resulting in a source of clean power, heat, and compressed hydrogen. Other applications include the reclamation of hydrogen from power plants and other industrial equipment where it is used for cooling, recovery of process hydrogen from heat treating processes, and semiconductor fabrication lines. Hydrogen can also be recovered from reformate streams and cryogenic boil-offs using this technology.
Image modeling using inverse filtering criteria with application to texture images (2002)

Higher-than second-order statistics are used in the paper to derive and implement two classes of inverse filtering criteria for consistent parameter estimation of asymmetric noncausal ARMA image models with known orders. Contrary to existing approaches, FIR inverse filters are employed and as a result image models with zeros on the unit bi-circle can be handled. The performance of these parameter estimators is evaluated with Monte Carlo simulations and texture classification experiments.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Tetrahydropyranyl‐protected poly( p ‐hydroxystyrene) containing vinyl ether compound for three‐component photopolymers (1998)

Poly(p-hydroxystyrene)s (PHSs) partially protected by tetrahydropyranyl (THP), PPT-x, containing 2,2′-bis(4-(2-(vinyloxy)ethoxy)phenyl)propane as a crosslinking agent were used as three-component photopolymers in combination with diphenyliodonium 9,10-dimethoxyanthracene-2-sulfonate (DIAS) as a photoacid generator. The PPT-x with a higher THP-protecting ratio was deprotected at higher temperatures than the PPT-x with a lower THP-protecting ratio. The conversions of vinyl ether compound in the photopolymer films were not related to the THP-protecting ratios in PPT-x and increased with increasing baking time. Under different THP-protecting ratios and prebaking temperatures, the PPT-x showed varying lithographic behavior between a positive-working mode and a negative-working mode. These three-component photopolymer solutions of PPT-x have good preservation stability. © 1998 John Wiley & Sons, Ltd.
The role of nonselective beta-blockers in the prevention of gastric variceal rebleeding (2008)

Comment
Coexistence of UAVs and Terrestrial Users in Millimeter-Wave Urban Networks (2022)

5G millimeter-wave (mmWave) cellular networks are in the early phase of commercial deployments and present a unique opportunity for robust, high-data-rate communication to unmanned aerial vehicles (UAVs). A fundamental question is whether and how mmWave networks designed for terrestrial users should be modified to serve UAVs. The paper invokes realistic cell layouts, antenna patterns, and channel models trained from extensive ray tracing data to assess the performance of various network alternatives. Importantly, the study considers the addition of dedicated uptilted rooftop-mounted cells for aerial coverage, as well as novel spectrum sharing modes between terrestrial and aerial network operators. The effect of power control and of multiuser multiple-input multiple-output are also studied.
Processus morphogénétiques (2019)

Enseignement Cours – Bases génétiques et cellulaires de l’évolution du cortex cérébral chez les primates Introduction Le cours aborde la question de la place des humains dans l’histoire des espèces animales et, tout particulièrement, celle de leur parenté avec les autres primates. Pour tout darwinien, sapiens est le résultat d’une évolution sans finalité et nous entretenons donc un lien de parenté avec les singes, particulièrement les deux espèces Pan troglodytes (les chimpanzés) et Pan panis...
Aluminum, Alzheimer's Disease, and the Olfactory Systema (1991)

In Alzheimer's disease, it has been recognized that there is a dramatic tendency for the development of neurofibrillary tangles among neurons of cortical regions associated with the olfactory system. We have demonstrated that neurofibrillary tangle-bearing neurons contain dramatically elevated levels of aluminum. The olfactory system, the only portion of the central nervous system with exposure to the external environment, is uniquely capable of uptake and transneuronal spread of exogenous substances. We argue that inasmuch as aluminum is not employed in any physiologic process, these deposits must arise from exogenous sources. Using parkinsonism-dementia complex of Guam as a model, we present data which suggest that the olfactory system is particularly vulnerable to damage and is affected very early in the disease. This supports the concept that etiologic agents of importance to this epidemic may be airborne in nature and may enter the central nervous system via the olfactory pathways.
Christopher Armstrong. Making Toronto Modern: Architecture and Design, 1895-1975. Montreal and Kingston: McGill-Queen’s University Press, 2014. 406 pp. 280 photos, illustrations and maps (2015)

Christopher Armstrong. Making Toronto Modern: Architecture and Design, 1895-1975. Montreal and Kingston: McGill-Queen’s University Press, 2014. 406 pp. 280 photos, illustrations and maps. Un article de la revue Urban History Review / Revue d'histoire urbaine (Environmental Nuisances and Political Contestation in Canadian Cities) diffusée par la plateforme Érudit.
Phosphorescent Platinum Dyads with Cyclometalated Ligands: Synthesis, Characterization, and Photophysical Studies (2008)

The synthesis, characterization, and photophysical properties are reported for a series of (C^N)Pt dyad complexes with cyclometalated ligands (C^N: F = 2-(4′,6′-difluorophenyl)pyridyl, tpy = 2-(4′-methylphenyl)pyridyl, thpy = 2-(2-thienyl)pyridyl, and btp = 2-(2-benzothienyl)pyridyl). The dyads are connected with a bridging ligand, sym-tetraacetylethane (tae), that consists of two 2,4-pentadionate units covalently linked at the 3-position. Stepwise synthesis was applied to obtain both homoleptic and heteroleptic dyads that have been characterized by 1H NMR and elemental analysis. X-ray crystallographic analysis shows a near orthogonal orientation of the two diketonate moieties in the di-tpyPt (84°) and FPt-thpyPt (89°). An investigation of the photophysical properties of the dyads has been carried out. For homodyads, the emission characteristics are governed by the nature of the cyclometalating ligand, allowing the emission to be tuned throughout the visible spectrum. The di-FPt and di-tpyPt dyads show a modest decrease in luminescent lifetimes compared to their mononuclear analogs. The di-FPt complex undergoes efficient self-quenching by an excimer that is presumed to have only π−π interactions. The heterodyads exhibit efficient intramolecular triplet energy transfer leading to the luminescence almost exclusively from the lower-energy moiety. The energy transfer is presumed to be mediated through the bridging tae ligand by a Dexter-like mechanism involving a combination of hopping and superexchange processes.
Rate Splitting Multiple Access for Next Generation Cognitive Radio Enabled LEO Satellite Networks (2022)

This paper proposes a cognitive radio enabled LEO SatCom using RSMA radio access technique with the coexistence of GEO SatCom network. In particular, this work aims to maximize the sum rate of LEO SatCom by simultaneously optimizing the power budget over different beams, RSMA power allocation for users over each beam, and subcarrier user assignment while restricting the interference temperature to GEO SatCom. The problem of sum rate maximization is formulated as non-convex, where the global optimal solution is challenging to obtain. Thus, an efficient solution can be obtained in three steps: first we employ a successive convex approximation technique to reduce the complexity and make the problem more tractable. Second, for any given resource block user assignment, we adopt KKT conditions to calculate the transmit power over different beams and RSMA power allocation of users over each beam. Third, using the allocated power, we design an efficient algorithm based on the greedy approach for resource block user assignment. Numerical results demonstrate the benefits of the proposed optimization scheme compared to the benchmark schemes.
Immuno cross-reactivity suggests that catecholamine biosynthesis enzymes and beta-adrenergic receptors may be related. (1987)

Turkey red blood cell, beta 1-adrenergic receptors (BARs) were prepared to electrophoretic homogeneity by affinity chromatography, size exclusion high performance liquid chromatography, and preparative sodium dodecyl sulfate-polyacrylamide gel electrophoresis and used to prepare rabbit polyclonal anti-BAR antibodies. Anti-BAR activity was confirmed by immunoadsorption of [125I]cyanopindolol-labeled BAR to a protein A affinity column using the anti-BAR antibodies. BAR was compared to the catecholamine biosynthetic enzyme dopamine B-hydroxylase (DBH) by anti-BAR antibody cross-reactivity. DBH was purified from bovine adrenal medullae chromaffin vesicles by ion exchange, size exclusion, and concanavalin A-Sepharose chromatography. Final DBH specific activities were 42 +/- 4 units/mg of protein. Homogeneity was confirmed by nondenaturing polyacrylamide gel electrophoresis. Both DBH and BAR were recognized by the anti-BAR antibodies on Western transfer and immunoblotting. No interactions were observed with preimmune controls. Similar results were obtained with glycosylated and deglycosylated DBH, suggesting that the anti-BAR antibodies recognize specific portions of DBH amino acid sequence and not associated carbohydrate. DBH-cross-reactive antibodies were also purified by affinity chromatography using immobilized DBH and shown to immunoadsorb [125I]cyanopindolol-labeled BAR by protein A affinity chromatography. These results suggest that the catecholamine biosynthetic enzyme DBH and BAR may be related in structure.
686 PREVALENCE, AWARENESS, TREATMENT AND CONTROL OF HYPERTENSION AMONG ASIAN INDIANS IN TWO GEOGRAPHIC REGIONS (2012)

Objective: Lifestyle and environmental factors play an important role in the pathogenesis of hypertension. We aimed to compare the epidemiology of hypertension in Asian Indians from two different geographic regions (Singapore and rural India). We hypothesize that the prevalence would be higher but the awareness, treatment and control of hypertension would be better in Singapore Indians than in rural Indians. Methods: We analyzed data from large population-based studies: the Singapore Indian Eye Study (SINDI, n = 3,228, aged 40–80 years, 49.2% women) and the Central India Eye and Medical Study (CIEMS, n = 3,591, aged ≥40 years, 52.6% women). Hypertension was defined as systolic BP ≥140 or diastolic BP ≥90 mm Hg or self-reported history/treatment for hypertension. Results: The crude prevalence of hypertension was higher in SINDI (59.7%), compared to CIEMS (28.2%). In multivariable models adjusting for potential confounders, increasing age and overweight showed a positive and ‘never drinking alcohol’ showed a protective association with hypertension in both populations. Primary/lower education, hypercholesterolemia and diabetes in SINDI and being female in CIEMS showed a positive association. Among those with hypertension, 35.9% in SINDI and 25.3% in CIEMS were aware of their condition of which 83% in SINDI and. 32% in CIEMS were on treatment for hypertension. The BP control was similar between the two populations (45% in SINDI and 47% in CIEMS). Conclusions: The prevalence, awareness and treatment for hypertension were higher in Singapore Indians than in rural Indians and the risk factor associations (socioeconomic and metabolic) were different between the two populations.
Tuning Material Properties of Alkaline Anion Exchange Membranes Through Crosslinking: A Review of Synthetic Strategies and Property Relationships (2022)

Alkaline anion exchange membranes (AAEMs) are an enabling component for next generation electrochemical applications, including alkaline fuel cells, alkaline water electrolyzers, CO2 electrochemical reduction, and flow batteries. While commercial systems, notably fuel cells, have traditionally relied on proton-exchange membranes (PEMs), hydroxide-ion conducting AAEMs hold promise as a way to reduce cost-per-device by enabling the use of less expensive non-platinum group electrodes and cheaper cell components. AAEMs have undergone significant material development over the past two decades resulting in substantial improvements in hydroxide conductivity, alkaline stability, and dimensional stability. Despite these advances, challenges still remain in the areas of durability, water management, high temperature performance, and selectivity. In this review we discuss crosslinking as a synthesis tool for tuning various AAEM material properties, such as water uptake, conductivity, alkaline stability, and selectivity, and we describe synthetic strategies for incorporating crosslinks during membrane fabrication.