gebhart/patrepeval huggingface dataset:
Measurement of an airflow velocity change using a cantilever with Pb(Zr, Ti)O 3 (2013)

We proposed a thin piezoelectric cantilever to measure an airflow velocity change. An airflow sensor using a PZT cantilever and a flow channel was fabricated. We measured the relationship between the airflow velocity change and the piezoelectric voltage of the cantilever. The dimensions of the sensor and the cantilever are 25 mm × 20 mm × 20 mm and 1500 μm × 1000 μm × 2 μm, respectively. We evaluated the effect of the diameter of the flow channel on the sensor response. It was demonstrated that the fabricated sensor generated an output voltage of several millivolts when the airflow velocity changed at a rate of approximately 1 m/s. It was observed that the output voltage increased as the diameter of the flow channel became small.
Photonic crystal surface emitting lasers based on epitaxial regrowth (2012)

This paper describes the flexibility in band-structure engineering which an all-semiconductor photonic crystal device makes possible, and the optimum photonic crystal design for achieving flat photonic bands and optimal coupling strengths. The realisation of a re-grown photonic crystal and the operating characteristics of this new type of device are discussed.
Sentence Compression with Semantic Role Constraints (2012)

For sentence compression, we propose new semantic constraints to directly capture the relations between a predicate and its arguments, whereas the existing approaches have focused on relatively shallow linguistic properties, such as lexical and syntactic information. These constraints are based on semantic roles and superior to the constraints of syntactic dependencies. Our empirical evaluation on the Written News Compression Corpus (Clarke and Lapata, 2008) demonstrates that our system achieves results comparable to other state-of-the-art techniques. 1
Alpha helix-inducing dimerization of synthetic polypeptide scaffolds on gold - a model system for receptor mimicking and biosensing (2004)

Alpha helix-inducing dimerization of synthetic polypeptide scaffolds on gold - a model system for receptor mimicking and biosensing
Gas-Filled Liposomes as Echocardiographic Contrast Agents in Rabbits with Myocardial Infarcts (1993)

These results are encouraging and suggest that gas-filled liposomes may be a useful contrast agent for echocardiography.
Intranasal M2SR (M2-Deficient Single Replication) H3N2 Influenza Vaccine Provides Enhanced Mucosal and Serum Antibodies in Adults (2022)

Abstract Background We previously demonstrated that an intranasal dose of 108 50% tissue culture infectious dose (TCID50) M2-deficient single replication (M2SR) influenza vaccine protected against highly drifted H3N2 influenza challenge in a subset of subjects who demonstrated ≥2-fold increase in microneutralization (MN) antibodies to Belgium2015 (the challenge strain) after vaccination. Here, we describe a phase 1b, observer-blinded, dose-escalation study demonstrating an increased proportion of responders with this signal of immune protection. Methods Serosusceptible subjects aged 18–49 years were randomized to receive 2 doses (108–109 TCID50) of M2SR or placebo administered 28 days apart. Clinical specimens were collected before and after each dose. The primary objective was to demonstrate safety of M2SR vaccines. Results The vaccine was well tolerated at all dose levels. Against Belgium2015, ≥ 2-fold increases in MN antibodies were noted among 40% (95% confidence interval [CI], 24.9%–56.7%) of subjects following a single 108 TCID50 M2SR dose and among 80.6% (95% CI, 61.4%–92.3%) after 109 dose (P &amp;lt; .001). A single 109 TCID50 dose of M2SR generated ≥4-fold hemagglutination inhibition antibody seroconversion against the vaccine strain in 71% (95% CI, 52.0%–85.8%) of recipients. Mucosal and cellular immune responses were also induced. Conclusions These results indicate that M2SR may provide substantial protection against infection with highly drifted strains of H3N2 influenza. Clinical Trials Registration NCT03999554.
ChemInform Abstract: Reactions of Thioxoheterocycles with N‐Chloro Amides. Part 1. N‐(2‐Pyridylthio)amides. (1988)

Abstract The N‐(2‐pyridylthio)amides (VI) are prepared by coupling 2‐thiopyridone (IV) with the N‐chloro sulfonamides or carboxylic amides (I) ‐ (III) partly via the hydrochlorides (V).
Molecular radiator reorientation collision kernels from Stark sublevel photon echoes (1986)

Radiator reorientation kernels are measured in Stark-tunable infrared transitions of 13CH3F. The dominant (ΔM = 1) kernel is obtained by a scale transformation from the shape of a two-pulse photon-echo intensity versus Stark voltage curve, at fixed large echo time delay. The quantum-mechanical transport equation in the presence of coherence M transfer and a dc electric field is reviewed, and the applications of photon echoes in a tunable Stark field to measure reorientation collision kernels are discussed.
Biodegradable poly(sebacic acid‐co‐ricinoleic‐ester anhydride) tamoxifen citrate implants: Preparation andin vitrocharacterization (2007)

Abstract The aim of this study was to prepare tamoxifen citrate loaded cylindrical polymeric implants for application at tumor sites. The implant was based on poly (sebacic acid‐ co ‐ricinoleic‐ester anhydride) 70 : 30 w/w [poly(SA‐RA) 70 : 30 w/w], a low‐melting, biodegradable, and biocompatible polymer. Implants were prepared by a standardized melt manufacturing method. Differential scanning calorimetry and scanning electron microscopy were used for implant characterization. In vitro drug release studies were performed in phosphate‐buffered saline (pH 7.4) at 37 ± 2°C. The drug content was estimated by high‐performance liquid chromatography. The differential scanning calorimetry studies showed that the tamoxifen citrate in the implants was in the amorphous state. The cumulative percentage of drug release from 10 and 20 wt % drug‐loaded poly(SA‐RA) 70 : 30 w/w implants after 30 days was found to be 42.36 and 62.60%, respectively. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Collection of Electrons in Dye-Sensitized Solar Cells Improved by Three Dimensional Fluorine Doped SnO<sub>2</sub> Transparent Electrodes (2010)

The collection of injected electrons for dye-sensitized solar cells (DSSCs) was improved by two studies of three dimensional fluorine doped SnO2 transparent electrodes (3D FTO). One of the studies conducted here involved making textured glass substrates of silica sphere particles and low resistance FTO films. The other study involved a transparent 3D FTO electrode incorporated into the porous titania layer. In order to suppress back reactions between I3- ions and FTO, the FTO film surfaces in the DSSCs had to be covered with compact titania films prepared by using titanyl nitrate solutions. We confirmed the time constants for the recombination and collection of the injected electrons by using optical modulation techniques. It was found that these 3D configurations contributed to the improvement in the performance of the DSSCs.
Blood pressure control in eNOS knock‐out mice: comparison with other species under NO blockade (2000)

Changes in arterial blood pressure (ABP) lead to changes in vascular shear stress. This mechanical stimulus increases cytosolic Ca2+ in endothelial cells, which in turn activates the endothelial isoform of the nitric oxide synthase. The subsequently formed NO reaches the adjacent vascular smooth muscle cells, where it reduces vascular resistance in order to maintain ABP at its initial level. Thus, NO may play an important role as a physiological blood pressure buffer. Previous data on the importance of eNOS for blood pressure control are reviewed with special emphasis on the fact that endogenous nitric oxide can buffer blood pressure variability (BPV) in dogs, rats and mice. In previous studies where all isoforms of the nitric oxide synthase were blocked pharmacologically, increases in blood pressure and variability were observed. Thus, we set out to clarify which isoform of the nitric oxide synthase is responsible for this BPV controlling effect. Hence, blood pressure control was studied in knock-out mice lacking specifically the gene for endothelial nitric oxide synthase with their respective wild-type controls. One day after surgery, under resting conditions, blood pressure was increased by 47 mmHg (P < 0.05), heart rate was lower (-77 beats min-1, P < 0.05), and BPV doubled (P < 0.05). Based on these results, we conclude that chronic blood pressure levels are influenced by eNOS and that there is a blood pressure buffering effect of endogenous nitric oxide which is mediated by the endothelial isoform of the nitric oxide synthase.
Correlation between lumbar skeletal muscle size and urinary incontinence after radical prostatectomy (2020)

Patients with RSMS had a lower urinary quality of life compared with non-RSMS patients after robot-assisted radical prostatectomy, and RSMS, independent of age or BMI, was predictive of postoperative urinary incontinence.
Molecular Modeling of Phase Behavior in Polymer Nanocomposites. (2016)

Abstract not provided.
ChemInform Abstract: “Genuine Heterocycles” from the Acid‐Induced Cyclization of (Silylamino)(imino)(chalcogeno)phosphoranes and as a Result of Chloride Ion Abstraction from Bis(bis(trimethylsilyl)amino)thiophosphoryl Chloride. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Analysis of Strategy and Spread of Russia-sponsored Content in the US in 2017 (2018)

The Russia-based Internet Research Agency (IRA) carried out a broad information campaign in the U.S. before and after the 2016 presidential election. The organization created an expansive set of internet properties: web domains, Facebook pages, and Twitter bots, which received traffic via purchased Facebook ads, tweets, and search engines indexing their domains. We investigate the scope of IRA activities in 2017, joining data from Facebook and Twitter with logs from the Internet Explorer 11 and Edge browsers and the Bing.com search engine. The studies demonstrate both the ease with which malicious actors can harness social media and search engines for propaganda campaigns, and the ability to track and understand such activities by fusing content and activity resources from multiple internet services. We show how cross-platform analyses can provide an unprecedented lens on attempts to manipulate opinions and elections in democracies.
Transcriptional Regulation by Iron of the Gene for the Transferrin Receptor (1986)

Treatment of K562 cells with desferrioxamine, a permeable iron chelator, led to an increase in the number of transferrin receptors. Increasing intracellular iron levels by treatment of cells with either human diferric transferrin or hemin lowered the level of the transferrin receptors. By using a cDNA clone of the human transferrin receptor, we showed that the changes in the levels of the receptor by iron were accompanied by alterations in the levels of the mRNA for the receptor. The rapidity of these changes indicated that the mRNA had a very short half-life. By using an in vitro transcriptional assay with isolated nuclei, we obtained evidence that this regulation occurred at the transcriptional level.
Tempe: An Interactive Data Science Environment for Exploration of Temporal and Streaming Data (2014)

Over the last two decades, data scientists performed increasingly sophisticated analyses on larger data sets, yet their tools and workflows remain low-level. A typical analysis involves different tools for different stages of the work, requiring file transfers and considerable care to keep everything organized. Temporal data adds additional complexity: users typically must write queries offline before porting them to production systems. To address these problems, this paper introduces Tempe, a web application providing an integrated, collaborative environment for both real-time and offline temporal data analysis. Tempe’s central concept is a persistent research notebook retaining data sources, analysis steps and results. Analysis steps are carried out in script editor that uses a live programming approach to display interactive, progressively updated visualizations. Tempe uses a temporal streaming engine, Trill [17], as its backend data processor. In the process of creating Tempe, we have discovered new interactivity and responsiveness requirements for Trill. Conversely, building around Trill has shaped the user experience for Tempe. We report on this cross-disciplinary design process to argue that end user experience can be an integral part of creating a data engine.
A phase I/II study of REGN5678 (Anti-PSMAxCD28, a costimulatory bispecific antibody) with cemiplimab (anti–PD-1) in patients with metastatic castration-resistant prostate cancer. (2021)

TPS174 Background: Bispecific antibodies (bsAbs) are emerging as a protein-based therapeutic strategy for directing T-cell-mediated cytotoxicity in a tumor antigen-specific manner, typically by binding to both tumor antigen and the CD3 receptor on T-cells. REGN5678 is a human IgG4-based, first-in-class costimulatory bsAb designed to target prostate tumors by bridging prostate specific membrane antigen expressing tumor cells with the costimulatory receptor, CD28, on T-cells, and providing amplified T-cell receptor-CD3 complex-mediated T-cell activation within the tumor through the activation of CD28 signaling. At the tumor site, REGN5678 may synergize with PD-1 inhibitors. In mouse models, REGN5678 in combination with a PD-1 antibody has improved anti-tumor activity compared with either therapy alone (Waite JC et al. Sci Transl Med. 2020:12;549). Methods: This is an open label, Phase I/II, first-in-human study evaluating safety, tolerability, pharmacokinetics (PK), and anti-tumor activity of REGN5678 alone and in combination with cemiplimab in patients with metastatic castration resistant prostate cancer (mCRPC) who progressed after prior therapy (NCT03972657). For inclusion, patients must have received at least two prior lines of systemic therapy (in addition to androgen deprivation therapy) approved for metastatic and/or castration-resistant disease including a second-generation anti-androgen therapy. REGN5678 is administered weekly; cemiplimab (350 mg) is administered once every 3 weeks. During dose escalation, a 3-week safety lead-in of REGN5678 monotherapy will be administered prior to addition of cemiplimab. Study therapies are administered until disease progression, intolerable adverse events, withdrawal of consent, or study withdrawal criterion is met. The primary objectives in dose escalation are to evaluate safety, tolerability, and PK of REGN5678 alone and in combination with cemiplimab. Expansion cohort(s) will be enrolled once a maximum-tolerated REGN5678/cemiplimab dose is reached, or if a recommended Phase 2 dose or doses have been determined. During the expansion phase, the primary objective is to assess clinical activity, as measured by objective response rate of REGN5678 in combination with cemiplimab per modified Prostate Cancer Working Group 3 criteria. At selected sites, prostate-specific membrane antigen PET/CT scans are performed at baseline and select time points on study. This study is currently open to enrollment. Clinical trial information: NCT03972657.
Polyacetylene single crystals (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolyacetylene single crystalsFrank S. Bates and Gregory L. BakerCite this: Macromolecules 1983, 16, 6, 1013–1015Publication Date (Print):June 1, 1983Publication History Published online1 May 2002Published inissue 1 June 1983https://pubs.acs.org/doi/10.1021/ma00240a037https://doi.org/10.1021/ma00240a037research-articleACS PublicationsRequest reuse permissionsArticle Views219Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Strong Cell‐Mediated Immune Responses Are Associated with the Maintenance of Low‐Level Viremia in Antiretroviral–Treated Individuals with Drug‐Resistant Human Immunodeficiency Virus Type 1 (2004)

Antiretroviral (ARV)-treated patients often maintain low to moderate levels of viremia, despite the emergence of drug-resistant human immunodeficiency virus (HIV). We studied host and viral factors that may contribute to the control of viral replication in a cohort of 189 adults. Among ARV-treated patients with detectable viremia, there was a bell-shaped relationship between Gag-specific CD4+ T cell responses and viremia, with the highest cellular immune responses observed in patients with plasma HIV RNA levels of 1000-10,000 copies/mL. In contrast, there was a negative association between Gag-specific CD4+ T cell responses and viremia among ARV-untreated individuals with wild-type HIV. Strong cellular immune responses among individuals with drug-resistant HIV predicted subsequent lack of virological progression. Finally, there was a positive correlation between replicative capacity and viremia. Collectively, these data suggest that the selection of drug-resistance mutations may reduce the pathogenic potential of HIV, which leads to a balanced state of enhanced cellular immunity and low-level viremia.
Plan de acción de tecnología de información basado en la metodología Cobit 4,1, en el dominio planificar y organizar, en la empresa Obrinsa, en el segundo semestre de 2012 (2012)

Pare efectos de esta tesis, se efectuo una breve resena sobre la empresa. En donde se describe el giro de negocio, asi como sus principales productos y clientes, dicha descripcion se realizo con el objetivo de conocer la empresa y saber a que se dedica. A continuacion se presento la estructura organizacional de la empresa y la estrategia que pretende seguir para lograr sus metas y objetivos, tambien se describen las operaciones que realiza, asi como los problemas y necesidades que tienen en cada una de sus areas.
Para la elaboracion del plan de accion de tecnologia se aplicaron los siguientes metodos de recopilacion de informacion: analisis FODA, entrevistas, encuestas, guias de observacion. Una vez elaborado el plan de accion de tecnologia de informacion y comunicacion a traves del cual esta empresa podra gestionar de una forma efectiva y eficiente los recursos del area TIC; basandose en estandares internacionales del uso de las tecnologias de informacion y comunicacion utilizando la metodologia COBIT 4.1, ya que esta permite el desarrollo de politicas claras y buenas practicas para el control de Tic en las organizaciones.
A Conceptual Framework for Engineering Chatbots (2018)

The increasing popularity of chatbots as virtual assistants has lead to many organizations releasing If-This-Then-That frameworks to engineer such chatbots. However, these frameworks often result in inflexible and difficult-to-maintain chatbots. This paper outlines a high-level conceptual framework for realizing flexible chatbots founded upon agent-oriented abstractions: goals, plans, and commitments.
Protocols for optimal readout of qubits using a continuous quantum nondemolition measurement (2007)

We study how the spontaneous relaxation of a qubit affects a continuous quantum nondemolition measurement of the initial state of the qubit. Given some noisy measurement record $\ensuremath{\Psi}$, we seek an estimate of whether the qubit was initially in the ground or excited state. We investigate four different measurement protocols, three of which use a linear filter (with different weighting factors) and a fourth which uses a full nonlinear filter that gives the theoretically optimal estimate of the initial state of the qubit. We find that relaxation of the qubit at rate $1∕{T}_{1}$ strongly influences the fidelity of any measurement protocol. To avoid errors due to this decay, the measurement must be completed in a time that decrease linearly with the desired fidelity while maintaining an adequate signal to noise ratio. We find that for the nonlinear filter the predicted fidelity, as expected, is always better than the linear filters and that the fidelity is a monotone increasing function of the measurement time. For example, to achieve a fidelity of 90%, the box car linear filter requires a signal to noise ratio of $\ensuremath{\sim}30$ in a time ${T}_{1}$, whereas the nonlinear filter only requires a signal to noise ratio of $\ensuremath{\sim}18$.
The vibrational response of single-chambered fish swimbladders to low-frequency sound (1996)

The gas-filled swimbladder of a fish resonates in the ambient noise field, scattering significant amounts of acoustic energy. The Non-invasive Vibration Amplitude Measurement System (NIVAMS) was used to measure the frequency response of the swimbladder of a freshwater species, the oscar (Astronotus ocellatus Cuvier), in a range from 200 to 2000 Hz. NIVAMS uses continuous wave ultrasound to measure swimbladder vibrational displacement amplitudes in vivo. Advantages of the NIVAMS are that it is non-invasive (no surgery is required to make the measurements) and that it is non-intrusive (the motion is unaltered by the measurement process). The response of the oscar's single-chambered swimbladder followed the general characteristics of
Abstract 2511: Glycogen synthase kinase 3 beta inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2/p53 pathway (2011)

Abstract Exposure of the brain to ionizing radiation can cause neurocognitive deficiencies. The pathophysiology of these neurological changes is complex and includes radiation-induced apoptosis in the subgranular zone of the hippocampus. We have recently found that inhibition of glycogen synthase kinase 3β (GSK-3β) resulted in significant protection from radiation-induced apoptosis in hippocampal neurons. The Molecular mechanisms of this cytoprotection include abrogation of radiation-induced accumulation of p53. Here we show that pretreatment of irradiated HT-22 neurons with small molecule inhibitors of GSK-3β SB216763 or SB415286, or with GSK-3β-specific shRNA resulted in accumulation of the p53-specific E3 ubiquitin ligase MDM2. Knockdown of MDM2 using specific shRNA or chemical inhibition of MDM2 prevented the protective changes triggered by GSK-3β inhibition in irradiated HT-22 and restored radiation cytotoxicity. We found that this could be due to regulation of apoptosis by subcellular localization and interaction of GSK-3β, p53 and MDM2. These data suggest that the mechanisms of radioprotection by GSK-3β inhibitors in hippocampal neurons involve regulation of MDM2-dependent p53 accumulation and interactions between GSK-3β, MDM2 and p53. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2511. doi:10.1158/1538-7445.AM2011-2511