gebhart/patrepeval huggingface dataset:
Characteristic Intestinal Microflora of Specific Pathogen-Free Mice Bred in Two Different Colonies and their Influence on Postnatal Murine Immunocyte Profiles (2005)

Cecal microflora of BALB/c mice originating from two different SPF-breeding colonies were compared. The analysis of cultivable bacteria in the ceca showed significantly higher numbers of total bacteria in BALB/cCrSlc (SLC mice) than in BALB/cA Jcl (JCL mice) (p<0.05), which were mainly based on higher numbers and occurrence of Peptococaceae. Bifidobacteria were detected only in SLC mice. Feeding an oligosaccharide, raffinose, to the mice also induced different shifts in the composition of cecal microflora and the concentration of cecal organic acids. In the second experiment, hysterectomy-derived (HD) SLC mice were fostered to SPF lactating SLC mothers, or SPF lactating JCL mice, together with the mother's own natural birth (NB) pups in each isolator. HD mice fostered to SLC-mothers showed significantly higher percentages of T-cell receptor alphabeta cells expressing a CD8alpha homodimer (p<0.05) and a CD8alphabeta heterodimer (p<0.001) in the intraepithelial lymphocytes (IEL) compared with HD mice fostered to JCL-mothers. IEL profiles of HD mice corresponded well to those of NB mice that were breast-fed by the same mothers. Differences in the ratio of B220(+)cells to Thy1.2(+)cells in the splenocytes were also observed as a trend between both HD mice fostered to SLC or JCL mothers (p=0.06). These results suggest that postnatal colonization of various characteristic intestinal microflora derived from SPF-breeding colonies results in differences in development of lymphocyte populations in the intestinal and systemic organs of mice.
Exploiting Quantization Uncertainty for Enhancing Capacity of Limited-Feedback MISO Ad Hoc Networks (2016)

In this paper we investigate the capacity of random wireless networks in which transmitters are equipped with multiantennas. A quantized version of channel direction information (CDI) is also available, provided by the associated single antenna receivers. We adopt tools of stochastic geometry and random vector quantization to incorporate the impacts of interference and quantization errors, respectively. We first study the capacity of Aloha, and channel quality information (CQI)-based scheduling, whereby the transmissions decision in each transceiver pair depends on the strength of the CQI against a prescribed threshold. We then propose a new scheduling scheme, namely modified CQI (MCQI), by which the quantization error is effectively incorporated in the scheduling. Further we obtain the capacity of MCQI-based scheduling. Simulation results confirm our analysis and show that the proposed MCQI-based scheduling improves the capacity compared to the CQI-based scheduling and Aloha. It is also seen that the performance boost is more significant where the feedback capacity is low and the network is dense. In comparison with the case of high feedback capacity, the network capacity is not reduced by low feedback capacity in the MCQI-based scheduling. This is of practical importance since the network designer can save the feedback resources by employing MCQI-based scheduling without compromising the capacity and increasing the receivers' complexity.
High‐resolution optical microscopy for characterising microstructural deformation in microtensile testing (2020)

Imaging surface deformation of a coupon specimen in microtensile testing with an optical microscope presents challenges due to the narrow depth of field (DoF) of optical microscopes. Materials being heterogeneous at microscopic length scale, the sample surface deforms into a complex 3D surface texture, evolving continuously as the loading increases. Because of the narrow DoF, the region that is in focus within the field of view (FoV) decreases substantially in size with the increasing out-of-plane heterogeneous deformation. To address this challenge, a method based on image blending and stabilisation of the captured image frames is proposed. Image blending combines the partial regions that are in focus from a set of successive image frames captured at different working distances from the object surface plane to construct a single image that has a large part of the FoV in focus. The blended images are then obtained at different levels of macroscopic strains, that is the global homogeneous strain, in order to characterise the evolution of the heterogeneous deformation. The image stabilisation removes any misalignments of the blended images by spatially realigning them choosing a common feature as a reference point. The validation of the proposed method with conventionally and additively manufactured stainless steel 316L (SS 316L) specimens demonstrates excellent improvement in image quality. Almost 100% of the FoV is maintained in focus regardless of the amount of out-of-plane heterogeneous deformation caused during tensile testing, which is quite remarkable for optical microscopy imaging. Consequently, the blended and stabilised images enhanced the accuracy of digital image correlation (DIC). Time-lapse videos of the deformation generated using these images captured the evolution of the slip bands and their transmission through twinning boundaries in the stainless steel microstructure. Overall, this study demonstrates the feasibility of using image-processing techniques to advance optical microscopy to image complex 3D surfaces evolving with time.
Ultraviolet Photoprocessing of Interstellar Dust Mantles as a Source of Polycyclic Aromatic Hydrocarbons and Other Conjugated Molecules (2000)

By co-depositing a gas mixture of simple carbon- and nitrogen-containing molecules with water on a 10 K surface and exposing it to ultraviolet radiation, we were able to form a residue. This residue was then placed aboard the EURECA satellite behind a magnesium fluoride window and exposed to solar radiation for 4 months before it was returned and analyzed. The resulting residue is believed to simulate the photoprocessing of organic dust mantles in the interstellar medium. Mass spectrometry indicated that the photoprocessing created a rich mixture of polycyclic aromatic hydrocarbons (PAHs) and other conjugated organic molecules, which may explain how PAHs are replenished in space.
Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain (2018)

[This corrects the article DOI: 10.1371/journal.pbio.2001882.].
Rigorous modeling of mid-IR QCLs with strong photon-induced carrier transport (2022)

Accurate simulation of V-I characteristics for mid-IR quantum cascade lasers (QCLs) with photon-induced carrier transport (PICT) is achieved by using the non-equilibrium Green’s function method coupled with the interface-roughness scattering formalism taking into account graded interfaces and axial correlation lengths. Analysis of 4.9 µm- and 8.3 µm-emitting, buried-heterostructure (BH) QCLs reveals that PICT action reduces the differential resistance by a factor of 2.5 and increases the maximum-current density by ~ 30 % compared to conventional BH QCLs, which explains their record-high, single-facet wall-plug efficiency values (i.e., 27 % and 17 %). Interface grading allows obtaining emission wavelengths close to experiment.
EREBUS Coupled Hydrodynamic Radiographic Dynamic Reconstruction & Limited View Reconstructions [Slides] (2021)

Abstract not provided.
Orientation and wear of the acetabular component in third generation alumina-on-alumina ceramic bearings (2007)

We studied 33 third generation, alumina ceramic-on-ceramic bearings retrieved from cementless total hip replacements after more than six months in situ. Wear volume was measured with a Roundtest machine, and acetabular orientation from the anteroposterior pelvic radiograph. The overall median early wear rate was 0.1 mm(3)/yr for the femoral heads, and 0.04 mm(3)/yr for the acetabular liners. We then excluded hips where the components had migrated. In this stable subgroup of 22 bearings, those with an acetabular anteversion of < 15 degrees (seven femoral heads) had a median femoral head wear rate of 1.2 mm(3)/yr, compared with 0 mm(3)/yr for those with an anteversion of > or =15 degrees (15 femoral heads, p < 0.001). Even under edge loading, wear volumes with ceramic-on-ceramic bearings are small in comparison to other bearing materials. Low acetabular anteversion is associated with greater wear.
Macroporous ZnO Foams by High Internal Phase Emulsion Technique: Synthesis and Catalytic Activity (2014)

Zinc(II) oxide nanoparticles were used for the stabilization of dicyclopentadiene (DCPD)-water-based high internal phase emulsions (HIPEs), which were subsequently cured using ring-opening metathesis polymerization (ROMP). The morphology of the resulting ZnO-pDCPD nanocomposite foams was investigated in correlation to the nanoparticle loading and nanoparticle surface chemistry. While hydrophilic ZnO nanoparticles were found to be unsuitable for stabilizing the HIPE, oleic acid coated, yet hydrophobic ZnO nanoparticles were effective HIPE stabilizers, yielding polymer foams with ZnO nanoparticles located predominately at their surface. These inorganic/organic hybrid foam-materials were subsequently calcined at 550 °C for 15 min to obtain inorganic macroporous ZnO foams with a morphology reminiscent to the original hybrid foam, and a specific surface area of 1.5 m(2) g(-1). Longer calcination time (550 °C, 15 h) resulted in a sea urchin like morphology of the ZnO foams, characterized by higher specific surface area of 5.5 m(2) g(-1). The latter foam type showed an appealing catalytic performance in the catalytic wet air oxidation (CWAO) process for the destruction of bisphenol A.
Compensation method for color defects in PDP due to different time responses of phosphors (2006)

On a plasma display panel (PDP), luminous elements of red, green, and blue have different time responses. Therefore, a colored trails and edges appear behind and in front of moving objects. In order to reduce the color artifacts, this paper proposes a motion-based discoloring method. Discoloring values are modeled as linear functions of a motion vector to reduce hardware complexity. Experimental results show that the proposed method has effectively removed the colored trails and edges of moving objects. Moreover, the clear image sequences have been observed compared to the conventional ones.
Scanning Transmission Electron Microscopy in a Scanning Electron Microscope for the High-Throughput Imaging of Biological Assemblies (2022)

Electron microscopy of soft and biological materials, or "soft electron microscopy", is essential to the characterization of macromolecules. Soft microscopy is governed by enhancing contrast while maintaining low electron doses, and sample preparation and imaging methodologies are driven by the length scale of features of interest. While cryo-electron microscopy offers the highest resolution, larger structures can be characterized efficiently and with high contrast using low-voltage electron microscopy by performing scanning transmission electron microscopy in a scanning electron microscope (STEM-in-SEM). Here, STEM-in-SEM is demonstrated for a four-lobed protein assembly where the arrangement of the proteins in the construct must be examined. STEM image simulations show the theoretical contrast enhancement at SEM-level voltages for unstained structures, and experimental images with multiple STEM modes exhibit the resolution possible for negative-stained proteins. This technique can be extended to complex protein assemblies, larger structures such as cell sections, and hybrid materials, making STEM-in-SEM a valuable high-throughput imaging method.
ESD for Automotive Applications (2015)

Automotive vehicles are becoming more and more complex systems, which includes high power equipment for electric drive, steering, and breaking at higher voltage level (>48 V), and this is a challenge in terms of EMC, including high-speed low voltage data transmission for auxiliary and entertainment features. The trade-off between EMC and system level ESD robustness becomes more challenging due to the mix of ICs of smaller technology and lower voltage levels. Signal-to-noise ratio gets more challenging for system level ESD design. This chapter discusses design constraints, operating voltage, and overvoltage tolerance, and on-board ESD protection and internal ESD protection. Due to the short-circuit constraints of the communications pins (CAN, LIN, FlexRay) to Vbat and GND, the ESD protection of these pins must also trigger beyond that level if the design is to be robust against double fault (short circuit and load dump).
53.1: A 10.0 inch 1080 × 2880 Capacitive Curved‐faced In‐cell Touch Panel for Automotive Use (2015)

In this study, we describe a 10.0‐inch 1080 × 2880 capacitive curved‐faced prototype liquid crystal display for automotive use, which has integrated in‐cell touch panel technology. A sufficient signal‐to‐noise ratio of 100–160 was achieved with this display despite the 1.1‐mm‐thick cover glass.
Neutron Technologies for Bioenergy Research (2012)

Neutron scattering is a powerful technique that can be used to probe the structures and dynamics of complex systems. It can provide a fundamental understanding of the processes involved in the production of biofuels from lignocellulosic biomass. A variety of neutron scattering technologies are available to elucidate both the organization and deconstruction of this complex composite material and the associations and morphology of the component polymers and the enzymes acting on them, across multiple length scales ranging from Angstroms to micrometers and time scales from microseconds to picoseconds. Unlike most other experimental techniques, neutron scattering is uniquely sensitive to hydrogen (and its isotope deuterium), an atom abundantly present throughout biomass and a key effector in many biological, chemical, and industrial processes for producing biofuels. Sensitivity to hydrogen, the ability to replace hydrogen with deuterium to alter scattering levels, the fact that neutrons cause little or no direct radiation damage, and the ability of neutrons to exchange thermal energies with materials, provide neutron scattering technologies with unique capabilities for bioenergy research. Further, neutrons are highly penetrating, making it possible to employ sample environments that are not suitable for other techniques. The true power of neutron scattering is realized when it is combined with computer simulation and modeling and contrast variation techniques enabled through selective deuterium labeling.
Formation of a new deep emission in Si+, S+, Se+, and Te+ ion-implanted GaAs (1986)

Photoluminescence studies of Si+, S+, Se+, and Te+ ion-implanted GaAs made by molecular beam epitaxy were carried out at 2 K. A new emission denoted by [D] was commonly obtained at 1.408 eV. It was also found that the controversial near band-edge emissions, ‘g’ and [g-g], which were originally produced by the ion implantation of acceptor impurities, were not formed by donor ion implantation.
COMPREHENSIVE MULTIPLATFORM ANALYSIS OF CDKN2A ALTERATIONS IN MENINGIOMAS (2023)

Abstract BTFC travel award recipient In meningiomas, CDKN2A/B deletions are associated with poor clinical outcomes but are exceeding rare in most cohorts (1-5% of cases). Large molecular datasets are therefore required to explore these deletions and their relationship to other CDKN2A alterations that may be more common, but also prognostic on a transcriptomic, epigenomic, and/or copy number level. METHODS: We used multidimensional molecular data of 560 meningioma samples from 5 independent cohorts to comprehensively interrogate the spectrum of CDKN2A alterations through DNA methylation, copy number variation, transcriptomics, and proteomics using an integrated molecular approach, and utilized preclinical models to validate our findings. RESULTS: Meningiomas with either CDKN2A/B deletions (partial or homozygous loss) or an intact CDKN2A gene locus but elevated mRNA expression (CDKN2Ahigh) both had poor clinical outcomes. Increased CDKN2A mRNA expression was a poor prognostic factor independent of deletion status. CDKN2A expression and p16 protein also progressively increased with tumor grade and more aggressive molecular and methylation groups. CDKN2Ahigh meningiomas and meningiomas with CDKN2A deletions were enriched for similar cell cycling pathways but dysregulated at different checkpoints (G1/S vs G2/M). p16 immunohistochemistry was unreliable in differentiating between meningiomas with and without CDKN2A deletions, but increased positivity was associated with mRNA expression. CDKN2Ahigh meningiomas were associated with gene hypermethylation, Rb-deficiency, and lack of response to CDK inhibition. CONCLUSIONS: In meningiomas, CDKN2A mRNA expression consistently increases with biological aggressiveness, is prognostic independent of copy number loss, and may be used as an important prognostic biomarker with therapeutic implications for resistance to CDK4/6 inhibitors clinically.
<title>X-ray scattering signatures for material identification</title> (1994)

X-ray scattering at low angles demonstrates diffraction effects that can be used to characterize materials. The effects of overlying material are shown not to affect the usefulness of the data for the identification of explosives. The important features in the scattering signature are identified.
Dependences of contraction/expansion of stacking faults on temperature and current density in 4H-SiC p–i–n diodes (2018)

To investigate the mechanism of contraction/expansion behavior of Shockley stacking faults (SSFs) in 4H-SiC p–i–n diodes, the dependences of the SSF behavior on temperature and injection current density were investigated by electroluminescence image observation. We investigated the dependences of both triangle- and bar-shaped SSFs on the injection current density at four temperature levels. All SSFs in this study show similar temperature and injection current density dependences. We found that the expansion of SSFs at a high current density was converted to contraction at a certain value as the current decreased and that the value is temperature-dependent. It has been confirmed that SSF behavior, which was considered complex or peculiar, might be explained mainly by the energy change caused by SSFs.
Shortwave Infrared Imaging with J-Aggregates Stabilized in Hollow Mesoporous Silica Nanoparticles (2019)

Tissue is translucent to shortwave infrared (SWIR) light, rendering optical imaging superior in this region. However, the widespread use of optical SWIR imaging has been limited, in part, by the lack of bright, biocompatible contrast agents that absorb and emit light above 1000 nm. J-Aggregation offers a means to transform stable, near-infrared (NIR) fluorophores into red-shifted SWIR contrast agents. Here we demonstrate that J-aggregates of NIR fluorophore IR-140 can be prepared inside hollow mesoporous silica nanoparticles (HMSNs) to result in nanomaterials that absorb and emit SWIR light. The J-aggregates inside PEGylated HMSNs are stable for multiple weeks in buffer and enable high resolution imaging <i>in vivo</i> with 980 nm excitation.
Synthesis of N-substituted ε-hexonolactams as pharmacological chaperones for the treatment of N370S mutant Gaucher disease (2012)

A series of N-substituted ε-hexonolactams have been designed and prepared by a concise route with a tandem ring-expansion reaction as the key step. Some of the N-substituted ε-hexonolactams show better enhancements to N370S mutant β-glucocerebrosidase activity than NB-DNJ and NN-DNJ. Both the experimental results and computational studies highlight the importance of the carbonyl group for stabilizing protein folds in the mutant enzyme. The structure-activity relationships are also discussed. These novel N-alkylated iminosugars are promising pharmacological chaperones for the treatment of N370S mutant Gaucher disease.
Heat Transfer Across a Two-Fluid-Layer Region (1986)

Heat transfer across a two-fluid-layer region is calculated for Rayleigh numbers in excess of the critical value. The method of solution is based on Landau’s comments regarding the onset of turbulence, following Malkus and others. The linear stability problem is solved for its eigenvalues and eigenfunctions, and the eigenfunctions are used to calculate the contribution of secondary motion to heat transfer. Results are obtained in terms of an overall Nusselt number as a function of Rayleigh number, midlayer thickness, and midlayer thermal conductivity.
Cost of Breast Cancer Treatment (1996)

<h3>Objective:</h3> To determine the longitudinal cost of the treatment of patients with breast cancer. <h3>Methods:</h3> An analysis was performed of 200 women with 205 newly diagnosed breast cancers during 1989 in a health maintenance organization population (US Healthcare, Blue Bell, Pa). Medical records and claims data were analyzed for the total costs of medical care during the 4-year period after diagnosis. The costs over time were analyzed for clinical stage and use of mammography screening. <h3>Results:</h3> The total costs of medical care during the 4-year period after diagnosis were strongly related to clinical stage at diagnosis, with higher total costs for patients with stages III to IV at diagnosis compared with patients with stages 0 to II at diagnosis. The cost for all stages of disease declined after years 1 to 2, with the exception of stage II, which increased slightly in years 3 to 4. The use of screening mammography was associated with a significant decrease in the cost of medical care during the 4-year study period. <h3>Conclusions:</h3> The goal of mammography screening programs should be to achieve downstaging to stages 0 to I to achieve reduction in breast cancer mortality and to reduce the overall consumption of health care resources for the treatment of breast cancer. These cost data should be considered within the framework of future cost-effective analysis for screening mammography programs. Arch Intern Med. 1996;156:2197-2201
Dual effects of the alloresponse by Th1 and Th2 cells on acute and chronic rejection of allotransplants (2009)

The contribution of direct and indirect alloresponses by CD4(+) Th1 and Th2 cells in acute and chronic rejection of allogeneic transplants remains unclear. In the present study, we addressed this question using a transplant model in a single MHC class I-disparate donor-recipient mouse combination. BALB/c-dm2 (dm2) mutant mice do not express MHC class I L(d) molecules and reject acutely L(d+) skin grafts from BALB/c mice. In contrast, BALB/c hearts placed in dm2 mice are permanently accepted in the absence of chronic allograft vasculopathy. In this model, CD4(+) T cells are activated following recognition of a donor MHC class I determinant, L(d) 61-80, presented by MHC Class II A(d) molecules on donor and recipient APC. Pre-transplantation of recipients with L(d) 61-80 peptide emulsified in complete Freund's adjuvant induced a Th1 response, which accelerated the rejection of skin allografts, but it had no effect on cardiac transplants. In contrast, induction of a Th2 response to the same peptide abrogated the CD8(+) cytotoxic T cells response and markedly delayed the rejection of skin allografts while it induced de novo chronic rejection of heart transplants. This shows that Th2 cells activated via indirect allorecognition can exert dual effects on acute and chronic rejection of allogeneic transplants.