gebhart/patrepeval huggingface dataset:
Process models for ultra-shallow junction technologies (1987)

Submicron technologies include low thermal budget processing, Ge <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> or Si <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> preamorphization implants, ultra-low energy B and As implants, thin oxides and silicide contacts. These new technologies and the models required to simulate them are not simple extrapolations of existing process models. Major new process variables include crystal damage produced during implantation and the annealing of this damage, point-defect injection during contacting and implantation parameters associated with preamorphization. In this paper we describe new process models that describe these effects. The models are based on extensive data generated as part of our shallow junction, submicron CMOS program, and the models have been imbedded in the PREDICT <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TM</sup> process simulation code.
Function blocks for decentralised analysis of product flow paths (2008)

We present an approach for modelling, computing and using information about product flow paths in processing plants. We first present a formalisation of our model of product flow, which is plant-oriented and only considers the possible spatial displacement of the material. The concept of product flow paths, which represents an important aspect of the semantics of a process, is derived from this model. We then present a method for the analysis of product flow paths in a plant which is based on classical search theory, is inspired on algorithms from routing in computer networks and from compilers, and is implemented in a fully decentralised manner by means of function block diagrams. With this, a simple, flexible and robust technique for yielding up-to-date information about product flow paths is achieved, which may be used by applications to provide additional functionalities.
Characterization, Expression, and Evolution of the Mouse Embryonic ζ-Globin Gene (1985)

We have determined the complete sequence of the embryonic alpha-like, zeta (zeta)-globin gene of the BALB/c mouse. The structure of this gene establishes the amino acid sequence of the mouse embryonic zeta-globin polypeptide chain and allows us to identify sequences within the gene that may be important for its expression. One of these is a 300-base segment that is tightly conserved between mice and humans and is located at the 5' end of the zeta-globin gene. By introducing the cloned gene into permanently transfected mouse erythroleukemic cell lines and comparing its transcript with that of zeta-globin mRNA derived from embryonic yolk sac erythrocytes, we are able to show that the cloned gene is transcriptionally active and that its transcript is correctly initiated and processed. Interestingly, the zeta-globin gene is also active when permanently transfected into an immunoglobulin-producing B-cell, a cell that presumably has tissue-specific requirements for gene expression. Further, a comparison of the amino acid coding sequence of the mouse zeta-globin gene to that of zeta-like globin genes of other species supports a revised evolutionary lineage in which goats and humans are closely related, whereas mice are further removed.
SecWalk: Protecting Page Table Walks Against Fault Attacks (2021)

The correct execution of a memory load and store is essential for the flawless execution of a program. However, as soon as devices are deployed in hostile environments, fault attacks can manipulate memory operations and subsequently alter the execution of a program. While memory accesses for simple processors with direct memory access can efficiently be protected against fault attacks, larger processors with virtual addressing lack this protection. However, the number of systems with larger application-class processors is growing, leaving many applications unprotected. It requires new countermeasures to efficiently protect memory accesses of processors with virtual memory against fault attacks. In this work, we present SecWalk, a design to efficiently protect all memory accesses of a program in the virtual and physical memory domain against fault attacks. We enhance residual-based pointer protection with a hardware-based secure page table walk inside the memory management unit. The page table walk securely translates a protected virtual address to a protected physical address by exploiting the redundancy properties of encoded addresses and a linking mechanism in the memory management unit. Furthermore, we extend the protection domain for virtual addresses to the TLB to also protect fast translations. To evaluate the overhead, we integrate SecWalk to an FPGA-based open-source RISC-V core, where SecWalk extends the area of the design by 10 %. The software evaluation on a set of microbenchmarks shows an average code overhad of 11.05 % and runtime overhead of 7.17 %. To show the applicability on real-life applications, we port the microkernel seL4 to SecWalk, which yields a code overhead of 13.1 % and a runtime overhead of 11.6 %. The evaluation shows the overhead is small considering that SecWalk automatically protects all memory accesses of arbitrary applications against faults.
Memory functioning in children and adolescents with autism. (2011)

These findings indicate that performance on measures of episodic memory is broadly reduced in autism, and support the conclusion that information encoding and organization, possibly due to inefficient cognitive processing strategies, rather than storage and retrieval, are the primary factors that limit memory performance in autism.
Venomous auger snail Hastula (Impages) hectica (Linnaeus, 1758): molecular phylogeny, foregut anatomy and comparative toxinology (2007)

The >10,000 living venomous marine snail species [superfamily Conoidea (Fleming, 1822)] include cone snails (Conus), the overwhelming focus of research. Hastula hectica (Linnaeus, 1758), a venomous snail in the family Terebridae (Mörch, 1852) was comprehensively investigated. The Terebridae comprise a major monophyletic group within Conoidea. H. hectica has a striking radular tooth to inject venom that looks like a perforated spear; in Conus, the tooth looks like a hypodermic needle. H. hectica venom contains a large complement of small disulfide-rich peptides, but with no apparent overlap with Conus in gene superfamilies expressed. Although Conus peptide toxins are densely post-translationally modified, no post-translationally modified amino acids were found in any Hastula venom peptide. The results suggest that different major lineages of venomous molluscs have strikingly divergent toxinological and venom-delivery strategies.
Metals in Medicine: Imaging Agents (2008)

Abstract The use of metal ions in diagnostic medicine is widespread. Metal complexes and nanoparticles are used clinically in magnetic resonance imaging, nuclear medicine (gamma scintigraphy and positron emission tomography), and X‐ray imaging. Preclinically, additional advances are being made in these fields through the creative application of metal complexes and metal‐containing nanoparticles. This article briefly describes different clinical imaging modalities and the physico‐chemical properties required for imaging agents. Commercial agents are used to illustrate these properties and to describe the clinical state of the art. Selected examples of exciting preclinical imaging agents that have shown efficacy in vivo also are described.
Moderators of Improvements in Fatigue Impact After a Self-management Intervention in Multiple Sclerosis (2021)

Abstract Fatigue is one of the most common and disabling symptoms of multiple sclerosis. A recent randomized controlled trial comparing a fatigue self-management program and a general multiple sclerosis education program found that both programs improved fatigue in participants with multiple sclerosis. Participants were randomized to a self-management program (fatigue: take control, n = 109) or a multiple sclerosis education program (multiple sclerosis: take control, n = 109). This secondary analysis of that trial used multilevel moderation analysis to examine moderators of treatment-related effects on fatigue (Modified Fatigue Impact Scale) from baseline through the 6-mo follow-up. The following potential treatment moderators were examined: age, sex, cohabitation/marital status, and baseline levels of self-efficacy, depression symptoms, and sleep quality. Cohabitation status (living with or without a spouse/partner) interacted with intervention group and time to predict fatigue impact ( P = 0.04). Fatigue: take control participants who lived with a spouse/partner showed a marginal effect in greater rate of improvement in fatigue compared with those who lived alone ( P = 0.08). However, rates of improvement in fatigue in multiple sclerosis: take control participants were similar in those living with or without a spouse/partner. These findings suggest that living with a spouse or partner may facilitate benefit from self-management interventions for multiple sclerosis–related fatigue. Future research should investigate the contribution of supportive others in self-management of fatigue in multiple sclerosis.
Silica alcogel containing essential oil for air and surface disinfections (2013)

Microorganisms can get indoors to form airborne particles (i.e., bioaerosols) through the heating, ventilation and air conditioning system, doors and windows. Human activities are another important source of indoor bioaerosols. Bioaerosols and bioaerosol (or touching)-contaminated surfaces are two main transmission routes of infectious diseases. Currently, bioaerosol removal mainly relies on filtration that is far from efficient. Moreover, microbes captured by filters remain viable and further grow. Here we develop a new alcogel for directly disinfecting bioaerosols and contaminated surfaces. The alcogels were fabricated by two-step sol-gel method from hydrolyzed silicon alkoxides and essential oils extracted from natural plants. Silica alcogel containing 5 wt% thyme oil can disinfect 95% Staphylococcus aureus (105 CFU/L) within 30 min and 99.999% Streptococcus pneumoniae, Legionella pneumophila, Shigella flexneri and Salmonella typhimurium (106 CFU/L) within 2 hours in the environment with 100 times alcogel volume, by controlledly releasing antimicrobial vapors (mainly thymol, carvacrol) detected in GC-MS.
Editorial Comment (2008)

No AccessJournal of UrologyAdult Urology1 Aug 2008Editorial Comment James A. Eastham James A. EasthamJames A. Eastham More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2008.04.101AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial Comment." The Journal of Urology, 180(2), p. 570 References 1 : Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med2004; 351: 1513. Google Scholar 2 : Cancer and Leukemia Group B (CALGB) 90203: a randomized phase 3 study of radical prostatectomy alone versus estramustine and docetaxel before radical prostatectomy for patients with high-risk localized disease. Urology2003; 62: 55. Google Scholar Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, New York© 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 180Issue 2August 2008Page: 570 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information James A. Eastham More articles by this author Expand All Advertisement PDF downloadLoading ...
Detection of magnetic dipolar coupling of water molecules at the nanoscale using quantum magnetometry (2018)

It is a crucial issue to study interactions among water molecules and hydrophobic interfacial water at the nanoscale. Here we succeed in measuring the nuclear magnetic resonance spectrum of a diamond-water interfacial ice with a detection volume of about $2.2\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}22}$ L. More importantly, the magnetic dipolar coupling between the two protons of a water molecule is resolved by measuring the signal contributed from about 7000 water molecules at the nanoscale. The resolved intramolecule magnetic dipolar interactions are about 15 and 33 kHz with spectral resolution of 5 kHz. This work provides a platform for hydrophobic interfacial water study under ambient conditions, with further applications in more general nanoscale structural analysis.
Design and optimization of the SOI field effect diode (FED) (2007)

This article deals with the importance of the structure of FED, that lies in the fact that by appropriately biasing it, its operation can be switched between SCR-like and diode-like. For devices with p-type body doping the depletion of electrons beneath G1 imposes an upper limit to the breakdown voltage. This paper proposes to use n-type body doping instead to achieve high breakdown voltage and reduce the gate length for higher turn-on speed and lower on-resistance.
Potent and Readily Accessible Bistramide A Analogues through Diverted Total Synthesis (2018)

A diverted total synthesis effort is described that is designed to prepare potent cytotoxins based on the actin-binding natural product bistramide A. The major focus of this study is the preparation of analogues that contain oxygenation at the C29 position, which is necessary for a key reaction in the sequence but is not present in the natural product. This process showed that C29 ketone analogues are accessed more readily and show similar potency compared to the natural product. The ability to incorporate C29 oxygenation and to replace a secondary alcohol by a primary alcohol allowed for the development of a more convergent approach that provides a potent analogue in just eight steps in its longest linear sequence.
Genetic deletion of AU-rich region in the tristetraprolin (TTP) transcript increases TTP stability and expression and provides protection against inflammatory diseases (INM1P.433) (2015)

Abstract Tristetraprolin (TTP) is an mRNA binding protein that binds to AU-rich elements (AREs) in the 3’-untranslated regions (3’UTR) of specific mRNAs, such as that encoding tumor necrosis factor (TNF), and increases their rate of mRNA turnover. TTP mRNA also contains AREs within its own 3’UTR that are partly responsible for its own rapid turnover. In the present study, we generated a novel TTP mouse line (TTPΔARE) with a 136 base deletion in the 3’UTR AU-rich region of TTP mRNA, and studied the effect of this genetic modification on the levels of TTP mRNA and protein, and susceptibility of the mice to experimentally-induced inflammatory conditions. TTP mRNA stability was found to be enhanced in TTPΔARE bone marrow-derived macrophages (BMDMs) and mouse embryonic fibroblasts (MEFs). TTP protein expression was increased, both in the basal state and upon LPS stimulation, in BMDMs, and in selected mouse tissues. LPS-induced expression of TTP target mRNAs, particularly Tnf and Il-1β, was significantly reduced in TTPΔARE BMDMs. Most importantly, TTPΔARE mice were almost completely protected from collagen antibody-induced arthritis, and exhibited significantly reduced inflammation in an imiquimod-induced model of psoriasis. These data suggest that increased levels of TTP can protect against some experimentally induced inflammatory diseases. They also raise the possibility that increasing TTP levels in man might be an attractive therapeutic approach in some inflammatory conditions.
How Do Bisphosphonates Inhibit Bone Metastasis In Vivo (2010)

Bisphosphonates are potent inhibitors of osteoclast-mediated bone resorption and have demonstrated clinical utility in the treatment of patients with osteolytic bone metastases. They also exhibit direct antitumor activity in vitro and can reduce skeletal tumor burden and inhibit the formation of bone metastases in vivo. However, whether such effects are caused by a direct action of bisphosphonates on tumor cells or indirectly through inhibition of bone resorption remains unclear. To address this question, we used here a structural analog of the bisphosphonate risedronate, NE-58051, which has a bone mineral affinity similar to that of risedronate, but a 3000-fold lower bone antiresorptive activity. In vitro, risedronate and NE-58051 inhibited proliferation of breast cancer and melanoma cell lines. In vivo, risedronate and NE-58051 did not inhibit the growth of subcutaneous B02 breast tumor xenografts or the formation of B16F10 melanoma lung metastasis. In contrast to NE-58051, risedronate did inhibit B02 breast cancer bone metastasis formation by reducing both bone destruction and skeletal tumor burden, indicating that the antitumor effect of bisphosphonates is achieved mainly through inhibition of osteoclast-mediated bone resorption.
Histological Skin Changes After Treatment with 675 nm Laser (2021)

<b><i>Objective:</i></b> To evaluate the histological effects of a new 675-nm laser device on the skin. <b><i>Background:</i></b> Innovative technologies based on physical principles have been proposed in recent years to improve the treatment of aging skin. Laser technology is currently being studied for its potential in skin care treatments. A new 675-nm laser device is being used for the treatment of hyperpigmentation, scars, and various types of wrinkles. <b><i>Methods:</i></b> A 42-year-old man underwent a 675-nm RedTouch<sup>®</sup> laser session for the treatment of aging signs on the neck. Two 2.5-mm biopsies were taken from the treated area and the adjacent area untreated with the laser, 45 days after the procedure. Comparison of the immunohistochemistry findings and assessment of the collagen and elastin fibers were performed by a board-certified dermatopathologist. <b><i>Results:</i></b> Skin biopsies revealed histological changes that comprised proliferation of new collagen fibers in the treated area, when compared to that in the untreated areas. <b><i>Conclusions:</i></b> Histological analysis suggests that the 675-nm laser has a potential role in stimulating collagen remodeling, with a significant increase in thin and new collagen fibers.
Analysis of 3Dimensional Reconstruction in a MR-guided NIR Tomography System (2006)

The algorithms for near-infrared (NIR) diffuse optical tomography within magnetic resonance imaging (MRI) of the female breast are analyzed in both circular and curved slab geometries.
Screening and Biological Effects of Marine Pyrroloiminoquinone Alkaloids: Potential Inhibitors of the HIF-1α/p300 Interaction (2016)

Inhibition of the hypoxia-inducible factor 1α (HIF-1α) pathway by disrupting its association with the transcriptional coactivator p300 inhibits angiogenesis and tumor development. Development of HIF-1α/p300 inhibitors has been hampered by preclinical toxicity; therefore, we aimed to identify novel HIF-1α/p300 inhibitors. Using a cell-free assay designed to test compounds that block HIF-1α/p300 binding, 170 298 crude natural product extracts and prefractionated samples were screened, identifying 25 active extracts. One of these extracts, originating from the marine sponge Latrunculia sp., afforded six pyrroloiminoquinone alkaloids that were identified as positive hits (IC50 values: 1-35 μM). Luciferase assays confirmed inhibition of HIF-1α transcriptional activity by discorhabdin B (1) and its dimer (2), 3-dihydrodiscorhabdin C (3), makaluvamine F (5), discorhabdin H (8), discorhabdin L (9), and discorhabdin W (11) in HCT 116 colon cancer cells (0.1-10 μM, p < 0.05). Except for 11, all of these compounds also reduced HIF-1α transcriptional activity in LNCaP prostate cancer cells (0.1-10 μM, p < 0.05). These effects occurred at noncytotoxic concentrations (<50% cell death) under hypoxic conditions. At the downstream HIF-1α target level, compound 8 (0.5 μM) significantly decreased VEGF secretion in LNCaP cells (p < 0.05). In COLO 205 colon cancer cells no activity was shown in the luciferase or cytotoxicity assays. Pyrroloiminoquinone alkaloids are a novel class of HIF-1α inhibitors, which interrupt the protein-protein interaction between HIF-1α and p300 and consequently reduce HIF-related transcription.
Dynamic Scheduling and Power Control in Uplink Massive MIMO with Random Data Arrivals (2019)

In this paper, we study the joint power control and scheduling in uplink massive multiple-input multiple-output (MIMO) systems with random data arrivals. The data is generated at each user according to an individual stochastic process. Using Lyapunov optimization techniques, we develop a dynamic scheduling algorithm (DSA), which decides at each time slot the amount of data to admit to the transmission queues and the transmission rates over the wireless channel. The proposed algorithm achieves nearly optimal performance on the long-term user throughput under various fairness policies. Simulation results show that the DSA can improve the time-average delay performance compared to the state-of-the-art power control schemes developed for Massive MIMO with infinite backlogs.
SOUS-CHAPITRE 9.1 Les défis de la microbiologie fondamentale : connaissance du monde microbien, génomique, physiologie-métabolisme, parois (2020)

SOUS-CHAPITRE 9.1 Les défis de la microbiologie fondamentale : connaissance du monde microbien, génomique, physiologie-métabolisme, parois was published in La maîtrise des maladies infectieuses on page 231.
The MPEG Surround Audio Coding Standard [Standards in a Nutshell] (2009)

This article provides a compact overview of the history, technology, and performance of MPEG Surround. The technology of MPEG Surround is based on the spatial audio coding (SAC) principle: In the encoder, a mono- or stereophonic down- mix is generated from the multichannel input signal, and additional parametric side information is extracted to guide the subsequent up-mix procedure in the decoder.With Moving Pictures Expert Group (MPEG) Surround, a data-rate efficient coding scheme for high-quality multichannel sound using novel parametric coding techniques has been standardized.
CHROMATOGRAPHIC CHARACTERISTICS OF SOME AROMATIC COMPOUNDS OF BIOLOGICAL INTEREST (1961)

Paper chromatographic data are reported on 220 aromatic compounds of biological interest, including phenolic acids, indoles, imidazoles, purines, pyrimidines, and some miscellaneous substances. R f data in four solvent systems and color reactions with 12 spray reagents are tabulated. Some correlations between structure of these compounds, relative R f , and color with various spray reagents are noted.
LTCC system with new high-ɛr and high-Q material co-fired with conventional low-ɛr base material for wireless communications (2007)

The authors have developed a new LTCC material with characteristics of high dielectric constant (ɛr), high quality factor (Q) and low temperature coefficient of capacitance (TCC). This material can be co-fired with a conventional base LTCC material and buried resistors with low temperature coefficient of resistance (TCR). The base material which consists of Al2O3 filler and glass, has low ɛr of 8.7 at 3 GHz. The newly developed LTCC material, which consists of Ba–(Re)–Ti–O filler, Al2O3 filler, and glass, has the following characteristics of ɛr of 15.1, Q of 900 at 3 GHz, and TCC of −10 ppm/K. The buried resistors consist of RuO2 and glass. Two different LTCC materials, a resistor material and a silver electrode paste can be co-fired as multi-layer substrates and are regarded as a new LTCC system. Constrained sintering could be applied to this LTCC system and the dimensions of substrates could be controlled with quite high accuracy. This LTCC system is expected to contribute to further miniaturization of RF circuits and the reduction of electrical loss.