gebhart/patrepeval huggingface dataset:
Diffusional charge transport through ultrathin films of radiofrequency plasma polymerized vinylferrocene at low temperature (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiffusional charge transport through ultrathin films of radiofrequency plasma polymerized vinylferrocene at low temperatureP. Daum, J. R. Lenhard, D. Rolison, and Royce W. MurrayCite this: J. Am. Chem. Soc. 1980, 102, 14, 4649–4653Publication Date (Print):July 1, 1980Publication History Published online1 May 2002Published inissue 1 July 1980https://pubs.acs.org/doi/10.1021/ja00534a014https://doi.org/10.1021/ja00534a014research-articleACS PublicationsRequest reuse permissionsArticle Views893Altmetric-Citations308LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An automated device to assess light redirecting properties of materials and perform sun course simulations: the Heliodome project (2005)

In this paper, the development of an original and time-efficient measurement device is proposed for the detailed investigation of the daylight distribution within buildings. It is meant to be used for two kinds of applications: -\tto assess the sunlight distribution inside scale models in an automated way so as to serve as a design and educational tool for architects and students and help them find solutions to improve the sunlight distribution within their building projects. -\tto achieve time-efficient bidirectional goniophotometric measurements of materials, typically used for innovative fenestration systems such as solar blinds, advanced glazing or coatings and daylight-redirecting devices, as well as energy-efficient artificial lighting components like luminaires reflectors e.g. The functioning principle of the device in both configurations is explained here and its early stages of development are presented: design and construction of the mechanical platform, command interface prototype and characteristics of the light detection system.
Cu‐Catalyzed Asymmetric Allylic Alkylations of Aromatic and Aliphatic Phosphates with Alkylzinc Reagents. An Effective Method for Enantioselective Synthesis of Tertiary and Quaternary Carbons. (2004)

Efficient enantioselective Cu-catalyzed allylic alkylations of aromatic and aliphatic allylic\nphosphates bearing di- and trisubstituted olefins are disclosed. Enantioselective C−C bond forming reactions\nare promoted in the presence of 10 mol % readily available chiral amino acid-based ligand (5 steps, 40%\noverall yield synthesis) and 5 mol % (CuOTf)&lt;sub&gt;2&lt;/sub&gt;·C&lt;sub&gt;6&lt;/sub&gt;H&lt;sub&gt;6&lt;/sub&gt;. Reactions deliver tertiary and quaternary stereogenic\ncarbon centers regioselectively and in 78−96% ee. Data regarding the effect of variations in ligand structure\non the efficiency and enantioselectivity of the alkylation process, as well as a mechanistic working model,\nare presented. The suggested model involves a dual role for the chiral Cu complex: association of the\nCu(I) center to the olefin is facilitated by a two-point binding between the carbonyl of the ligand's amide\nterminus and the PO of the substrate.
ATEZOLIZUMAB + OBINUTUZUMAB + VENETOCLAX IN PATIENTS WITH RELAPSED OR REFRACTORY FOLLICULAR LYMPHOMA: PRIMARY ANALYSIS OF A PHASE 2 TRIAL FROM LYSA (2021)

Introduction: Relapsed and refractory (R/R) Follicular Lymphoma (FL) treatment remains challenging. Atezolizumab (ATE) and obinutuzumab (OBI) are monoclonal antibodies acting respectively to inhibit T-lymphocyte exhaustion or by inducing lymphoma cells cytotoxicity, whereas venetoclax (VEN) is a small molecule inhibiting BCL-2. Combining tumor-targeted therapies with agents that enhance anti-tumor immunity represents an attractive treatment paradigm. This LYSA sponsored multicenter phase 2 trial (NCT03276468) evaluated ATE, OBI and VEN combination in R/R B-cell lymphomas. Herein, we present primary efficacy and safety data from the FL cohort. Methods: Patients ≥18 years with biopsy-confirmed R/R FL who failed at least one line of therapy were eligible. OBI was given IV at 1 g on day (D) 1, 8 and 15 of cycle (C) 1 and on D1 from C2 to C8 every 3 weeks. ATE was given IV, 1.2 g every 3 weeks, started at D2 of C1, then administered at D2 of each cycle for 24 cycles. VEN was given orally at 800 mg/D at full dose, starting on D8C1 for 24 cycles. The primary endpoint was the Overall Response Rate (ORR) evaluated by Lugano criteria at the end of induction (EOI) after 8 cycles of ATE, OBI and VEN (M6) or at premature treatment discontinuation. Results: At the time of the primary analysis (08 Jan 2021), 58 FL patients were enrolled. The median follow-up was 14.5 months, 45 patients completed induction phase and 34 patients started maintenance. Baseline characteristics were: median age, 56 years (38-83); male, 66.1%; Ann Arbor Stage III/IV, 85.7%; FLIPI HR, 47.3%; > 2 prior lines of therapy, 32.1%; refractory to last line of prior regimen, 26.8%; and exposed to ASCT, 30.4%. The OMRR at EOI was measured at 53.6% [41.8%-65.1%], including 30.4% of CMR whereas OMRR at C4 was 75.0% [61.6%-85.6%], including 28.6% of CMR. Best of Response Rate (BOR) was 80.4% [69.6%-88.6%] including 35.7% of CMR. To date, 23 patients relapsed after an initial response (51% of the 45 responders). Thirty-seven patients (63%) received the full induction treatment. At the time of analysis, a median of 8 cycles [1-8] has been administered. A total of 41 (70.7%) patients experienced grade 3–4 adverse event (AE) and 1 had an AE that led to discontinuation of any drug. AE of grade 3 or more reported in at least 10% of patients were neutropenia (41.4%), thrombocytopenia (24.1%) and lymphopenia (22.4%). Of note, two patients experienced autoimmune colitis (grade 2 and 3) and one patient experience a grade 2 immune-related pancreatitis during induction. Conclusion: ATE, OBI and VEN combo appears to be well tolerated, with no unexpected toxicity brought by the combination. The ORR at EOI seems to be comparable to other innovative regiments in this setting, with durable responses to date. The research was funded by: Roche, Abbvie Keywords: Indolent non-Hodgkin lymphoma, Combination Therapies, Immunotherapy No conflicts of interest pertinent to the abstract.
Direct laser writing of efficient effective second order nonlinear optical properties in a tailored silver-doped phosphate glass (2013)

International audience
Fairness and Throughput in Switch on Event Multithreading (2006)

The need to reduce power and complexity will increase the interest in switch on event multithreading (coarse grained multithreading). Switch on event multithreading is a low power and low complexity mechanism to improve processor throughput by switching threads on execution stalls. Fairness may, however, become a problem in a multithreaded processor. Unless fairness is properly handled, some threads may starve while others consume all of the processor cycles. Heuristics that were devised in order to improve fairness in simultaneous multithreading are not applicable to switch on event multithreading. This paper defines the fairness metric using the ratio of the individual threads' speedups, and shows how it can be enforced in switch on event multithreading. Fairness is controlled by forcing additional thread switch points. These switch points are determined dynamically by runtime estimation of the single threaded performance of each of the individual threads. We analyze the impact of the fairness enforcement mechanism on throughput. We present simulation results of the performance of switch on event multithreading. Switch on event multithreading achieves an average speedup over single thread of 24% when no fairness is enforced. In this case, over a third of our runs achieved poor fairness in which one thread ran extremely slowly (10 to 100 times slower than its single thread performance) while the other thread's performance was hardly affected. By using the proposed mechanism we can guarantee fairness of 1/4, 1/2 and 1 for a small performance loss of 2.2%, 3.7% and 7.2% respectively
Influence of Solid-State Reactions at the Electrode−Electrolyte Interface on High-Temperature Potentiometric NOx-Gas Sensors (2007)

The electrical signal from yttria-stabilized zirconia (YSZ) electrolyte-based potentiometric gas sensors is dependent on the electrochemical reactivity of the gases around the triple-phase boundary points. However, chemical reactions taking place at these triple-points can influence the performance of gas sensors, typically resulting in reduction of the electrochemical signal. In this paper, the focus is on a NOx sensor using Pt-zeolite Y as the reference electrode and WO3 as the sensing electrode. Significant improvement of NOx sensitivity measured at 600 °C was noted if the sensor assembly was heated to 950 °C as compared to 700 °C. From temperature-programmed desorption (TPD), diffuse reflectance FT-IR (DRIFTS), and chemical reactivity measurements, NOx interaction with YSZ was found to be strong, forming surface nitrates on YSZ and exhibiting high activities toward NOx equilibration. On the contrary, NOx adsorption on heat-treated WO3−YSZ mixtures was found to be weak and the surface was barely active toward NOx equilibration (2NO + O2 ↔ 2NO2) even at 600 °C. From powder diffraction and Raman experiments, it was discovered that WO3 reacts with YSZ upon thermal treatment, resulting in the formation of polytungstates and monoclinic ZrO2. These interfacial species suppress the chemical reactions around the triple-phase boundary because of their lower NOx catalytic activities, thereby enhancing the electrochemical sensor signal.
Metallic Bonding of Ceramic Armor Using Reactive Multilayer Foils (2008)

The room temperature brazing and soldering of ceramic armor to metallic plates is described. the novel metallic bonding process uses reactive multilayer foils (NanoFoil™) as local heat sources to melt braze or solder layers placed between the ceramic and metal components. by replacing furnace cycles with local heating this NanoBond™ process eliminates significant heating of the components and thus large area components can be bonded relatively stress-free. Examples of bonding Al2O3 to aluminum and of bonding SiC to titanium are presented and several configurations involving different braze and solder layers have been investigated in detail for the bonding of SiC to titanium. Shear strengths have been measured and are found to be significantly higher compared to those measured for similar samples bonded by epoxy adhesives. Numerical predictions of heat flow are also described for the reactive joining process and are validated by IR measurements. Lastly, bond areas over 100 cm2 are demonstrated.
Design and demonstration of a high-speed, multichannel, optical-sampling oscilloscope (1996)

Free-space digital optical systems have demonstrated the capability to provide thousands of optical connections between optoelectronic chips. This dense concentration of channels creates substantial challenges in monitoring individual connections for diagnostic purposes without compromising performance. Prom the concept of stroboscopic techniques, we have designed and constructed a multichannel optical diagnostic tool that operates analogously to an electronic-sampling oscilloscope. The tool is economically constructed by the use of commercially available video cameras and video-enhanced personal computers. An integrated software application operates the tool and displays multiple-channel waveforms. We demonstrate the oscilloscope-sampling optical waveforms of a two-dimensional optoelectronic modulator array operating at data rates from 0.5 to 4 Gbits/s.
Author’s Reply (2018)

The authors would like to thank He <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">et al.</i> <xref ref-type="bibr" rid="ref1" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">[1]</xref> for showing interest in our work <xref ref-type="bibr" rid="ref2" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">[2]</xref> .
Psychomotor profiling with Bayesian neworks (2009)

A high level of psychomotor abilities often is essential for successfully operating many technical systems and especially medical and rehabilitation devices. This paper introduces an approach to enable a technical system to automatically assess its user's level of psychomotor abilities, so that it can adapt its level of automation and provide the user with more or less assistance depending on the individual user profile. For this purpose, a study has been conducted during which the motor abilities of the participants have been assessed and their wheelchair control behavior recorded. Bayesian networks (BN) and structural equation models (SEM) have been applied to model the relationships between the wheelchair control behavior and the motor abilities of the participants. The BN demonstrate usefulness and magnificent advantages compared to the SEM for modeling uncertainty in structure and parameter dependencies, which are shown by validation experiments. Although only a small amount of data samples (23 participants) was available for model generation, a target variable reflecting the user's precision ability was successfully classified based on real data input in more than 82% of cases.
EcAMSat: Effect of Space-Flight on Antibiotic Resistance of a Pathogenic Bacterium and its Genetic Basis (2015)

Human immune response is compromised in space and incidence of urinary tract infections (UTI) in astronauts has been reported. We have found that the causative agent of UTI, the uropathogenic Escherichia coli, becomes more resistant to gentamicin (Gm), which is commonly used to treat this disease, under modeled microgravity conditions (MMG), the increase being controlled by the stress response master regulator, σs. While the wild type bacterium becomes virtually invincible under MMG, the strain missing this sigma factor barely survives. We report here preparatory ground work for testing this finding in space flight on a nanosatellite. We have shown that the effect of Gm treatment on culture viability is directly correlated to increased Alamar Blue (AB) reduction; we have identified conditions to keep the experimental elements - the bacterial cultures, Gm, and AB - in a state of viability and potency to permit successful spaceflight experimentation given the necessary constraints. Spaceflight kinetics of AB reduction will be transmitted from the satellite via telemetry. The PharmaSat hardware previously used for space experimentation with yeast was modified to permit studies with bacteria by reducing the filter pore size and increasing fluidics volume to enable more fluid exchanges. Several verification tests have been run using the nanosatellite's flight software and prototype hardware. Cells were grown to stationary phase to induce the σs-controlled stress resistance and treated with Gm. Without Gm, the mutant took longer than the wild type to reduce the AB; this time difference increased almost 8 fold at 55 μg/mL Gm concentration. Thus, using flight hardware the mutant shows similarly increased sensitivity to Gm compared to the wild type to that found in our pilot microtiter plate experiments. Previous inflight experiments have given contradictory results concerning bacterial antibiotic resistance; none has yet explored the involvement of specific genes in this phenomenon. With our system ready to fly in late 2015/early 2016, these questions can be approached
Electrochemical Quantification of Extracellular Local H 2 O 2 Kinetics Originating from Single Cells (2017)

Using a scanning electrochemical microscope and bare platinum disk ultramicroelectrodes, we established sensitive long-term measurements of extracellular [H<sub>2</sub>O<sub>2</sub>] kinetics originating from single primary human monocytes (MCs) ex vivo. For the electrochemical techniques square wave voltammetry, cyclic and linear scan voltammetry, and chronoamperometry, detection limits for [H<sub>2</sub>O<sub>2</sub>] were determined to be 5, 50, and 500 nM, respectively. Following phorbol ester stimulation, local [H<sub>2</sub>O<sub>2</sub>] 5-8 μm above a single MC increased by 3.4 nM/s within the first 10 min before reaching a plateau. After extracellular addition of H<sub>2</sub>O<sub>2</sub> to an unstimulated MC, the local [H<sub>2</sub>O<sub>2</sub>] decreased on average by 4.2 nM/s due to degradation processes of the cell. Using the scanning mode of the setup, we found that H<sub>2</sub>O<sub>2</sub> is evenly distributed around the producing cell and can still be detected up to 30 μm away from the cell. The electrochemical single-cell measurements were validated in MC populations using electron spin resonance spectroscopy and the Amplex<sup>®</sup> UltraRed assay. Innovation and Conclusion: We demonstrate a highly sensitive, spatially, and temporally resolved electrochemical approach to monitor dynamics of production and degradation processes for H<sub>2</sub>O<sub>2</sub> separately. Local extracellular [H<sub>2</sub>O<sub>2</sub>] kinetics originating from single cells is quantified in real time. Antioxid. Redox Signal. 29, 501-517.
A Machine Learning Approach to Linking FOAF Instances (2010)

The friend of a friend (FOAF) vocabulary is widely used on the Web to describe individual people and their properties. Since FOAF does not require a unique ID for a person, it is not clear when two FOAF agents should be linked as coreferent, i.e., denote the same person in the world. One approach is to use the presence of inverse functional properties (e.g., foaf:mbox) as evidence that two individuals are the same. Another applies heuristics based on the string similarity of values of FOAF properties such as name and school as evidence for or against co-reference. Performance is limited, however, by many factors: non-semantic string matching, noise, changes in the world, and the lack of more sophisticated graph analytics. We describe a supervised machine learning approach that uses features defined over pairs of FOAF individuals to produce a classifier for identifying co-referent FOAF instances. We present initial results using data collected from Swoogle and other sources and describe plans for additional analysis.
The use of non-bronchoscopic brushings to study the paediatric airway (2005)

Non-bronchoscopic brushing in children is safe and easy to perform, and is not associated with any complications. Using this technique, adequate numbers of epithelial cells can be retrieved to allow cell culture, western blotting, real time PCR, and microarray analysis. The purpose of this study is to demonstrate the utility of non-bronchoscopic airway brushing to obtain and study epithelial cells and to encourage others so that we can accelerate our knowledge regarding the role of the epithelium in childhood respiratory disease.
Supplementary Tables 1-2 from PlGF/VEGFR-1 Signaling Promotes Macrophage Polarization and Accelerated Tumor Progression in Obesity (2023)

&lt;p&gt;Supplementary Table 1: Protein quantification of cytokines in tumors and plasma of WT and Flt1TK-/- obese using ELISA; Supplementary Table 2: Quantification of the expression of IL-1ÃƒÅ½Ã,Â² and VEGFR-1 in TAMs from PAN02 tumors by mmunofluorescence.&lt;/p&gt;
A serum proteomic approach to gauging the state of remission in Wegener's granulomatosis (2005)

This serum proteomic profiling approach appears to be useful in distinguishing between states of stable clinical remission and active disease. Further validation and refinement of this strategy may help clinicians apply immunosuppressive therapies more judiciously among their patients, thereby avoiding morbidity and mortality from excessive treatment. Identification of the most robust and clinically useful combinations of ions will permit the rational selection of molecules for sequencing and analysis.
Fast Adaptive Penalized Splines (2008)

This article proposes a numerically simple method for locally adaptive smoothing. The heterogeneous regression function is modeled as a penalized spline with a varying smoothing parameter modeled as another penalized spline. This is formulated as a hierarchical mixed model, with spline coefficients following zero mean normal distribution with a smooth variance structure. The major contribution of this article is to use the Laplace approximation of the marginal likelihood for estimation. This method is numerically simple and fast. The idea is extended to spatial and non-normal response smoothing.
EMR-3 (2010)

Epidermal growth factor module-containing mucin-like hormone receptor-3 (EMR-3) is a G-protein coupled receptor with unknown ligand and cellular function. Upregulation of EMR-3 in glioblastoma (GBM) multiforme is associated with poor survival. We investigated the expression patterns and functional significance of EMR-3 in GBM using immunohistochemistry, western blot, reverse transcription PCR, and small interfering RNA knockdown in proliferation and invasion assays. EMR-3 is variably expressed in primary human GBM tissues and cell lines. Knocking down EMR-3 has no impact on cellular proliferation, but decreases cellular invasion by greater than 3-fold. EMR-3 is a potential mediator of cellular invasion in GBM. Given the poor survival associated with high levels of EMR-3 expression in glioma patients, our results provide impetus to explore EMR-3 as a potential therapeutic target.
Bispectral analysis of intracardiac electrograms (2002)

Previous work has shown that the average magnitude-squared coherence (MSC) differentiates ventricular tachyarrythmias and discriminates between fibrillatory and nonfibrillatory rhythms. The MSC quantifies the extent to which linear dynamics explain time series covariability. The magnitude-squared bicoherence (MSBC) does the same for bilinear dynamics. Unlike the MSC, which must be computed from two time series, the MSBC can be calculated from a single time series. The average magnitude-squared autobicoherence is computed for a collection of intracardiac electrograms. Results indicate that it has capabilities similar to average MSC in differentiating ventricular tachyarrythmias and discriminating between fibriallatory and nonfibrillatory rhythms. The MSBC might be used in implantable devices for cardiac monitoring and intervention to provide cross-validitory and localized information on cardiac dynamics. Moreover, its quantification of nonlinear dynamics may improve understanding of the intricate electrical organization of the heart.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
RESPONSE TO THYROTROPHIN RELEASING HORMONE IN KLINEFELTER'S SYNDROME (1978)

In eleven patients with Klinefelter's Syndrome TSH, T4 and T3 levels have been measured after stimulation with TRH. The eleven patients included three who had been noted to have a low radioactive iodine uptake and two of these also had abnormally low T4 levels. Three of the patients were receiving androgen replacement therapy. A normal response to TRH was observed in all cases.