gebhart/patrepeval huggingface dataset:
CDMA for communications in the aeronautical environment (2002)

MITRE's Center for Advanced Aviation System Development (CAASD) is involved in planning a next-generation voice/data network for the FAA's Air-Ground/Ground-Air communication system. This system has some unique operational requirements, which make the comparison between TDMA and CDMA a difficult one (as it also is in current cellular radio systems). This work, in support of CAASD, attempts to outline the key attributes of CDMA communication systems, specifically direct-sequence spread spectrum systems. A brief comparison with more traditional multiple access schemes (TDMA and FDMA), is made and then direct-sequence CDMA modulation and demodulation for a simple transmitter and receiver, in a single "cell" environment, is described. The CDMA waveform description yields expressions which allow estimation of system capacity-the number of simultaneously active channels the system can support. Non-idealities such as additional (interfering) cells and imperfect power control are also considered. Finally, TDMA capacity expressions are reviewed and some comparative estimated capacity results for our VHF Air-Ground/Ground-Air application are shown, using waveforms based upon terrestrial cellular schemes.
Abstract 3500: T cells redirected against HER2 for the adoptive immunotherapy for HER2-positive osteosarcoma (2012)

Abstract INTRODUCTION: The prognosis for patients with advanced osteosarcoma (OS) has not improved over the last two decades. Hence novel biologically-based therapies, such as immunotherapy, are needed for these patients. We have shown in preclinical studies that T cells, genetically modified with a HER2-specific chimeric antigen receptor (CAR; HER2-CAR T cells), kill HER2+ OS cells ex vivo and induce regression of HER2+ OS xenografts in animal models. Based on these findings we developed a Phase I/II clinical study with HER2-CAR T cells in patients with metastatic and/or recurrent OS. METHODS: The primary objective of this clinical trial is to determine the safety of escalating doses of HER2-CAR T cells in patients with advanced HER2+ OS. The secondary objective is to determine the expansion, persistence and anti-tumor effects of infused HER2-CAR T cells. RESULTS: 43 (78%) out of 55 screened OS patients had HER2+ tumors. Twenty one HER2-CAR T-cell lines have been generated to date by retroviral transduction. Median HER2-CAR expression was 67.4% (range 50.7-85.6%) and HER2-CAR T cells killed HER2+ OS cells in contrast to non-transduced T cells (p &amp;lt;0.0001). The median CD4+:CD8+ T-cell ratio was 1:1.3, and T-cell products contained naïve (CD45RA+; median: 11.8%; range 2.4-33.2%), effector memory (CD45RO+/CCR7-/CD62L-; median: 29.3%; range: 7.8-67.5%), and central memory T cells (CD45RO+/CD62L+; median 55.9%; range: 21.9-87.9%). Nine patients have been infused so far at HER2-CAR T-cell doses between 104/m2 to 1x106/m2. Infusions were well tolerated without systemic side effects, and no increase of proinflammatory cytokines (IL-2, IFN-γ, GM-CSF, TNF-α) was observed in the patients’ plasma post infusion. HER2-CAR T cells were detectable for up to 3 months post infusion. CONCLUSION: HER2-CAR T cells have shown promising antitumor activity in preclinical OS animal models. We are currently evaluating the safety and efficacy of HER2-CAR T cells in a Phase I/II clinical study. Initial safety data at low T-cell dose levels are encouraging, warranting further active exploration of HER2-CAR T-cell based therapies for OS and other HER2+ malignancies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3500. doi:1538-7445.AM2012-3500
In vitro Degradation Behavior of Photopolymerized PEG Hydrogels as Tissue Engineering Scaffold (2006)

PEGDA was photopolymerized to form hydrogels under different UV light irradiation times. In order to investigate the degradation rate in vitro, the various PEGDA hydrogels were incubated in PBS solution at 37°C in shaking water bath system. The physical-chemical properties such as pH values, dimension, mass and volume change, compressive strength and Young's modulus were measured. MALDI-MS and SEM were employed to evaluate the PBS solutions and corroded hydrogels after a designed period of time till 8 weeks. The results indicate that the PEGDA formed hydrogels can be tailored with prompted properties specifically for various cell-based tissue engineering needs.
Anisotropie joint Schölte- and Love-wave inversion (2021)

Summary Seismic multicomponent seabed acquisition systems enable us to measure Scholte- and Love-waves propagating along the sea bottom. Scholte- and Love-waves phase velocity dispersion curves be inverted for estimating shallow near seabed vertical and horizontal S-wave velocities, respectively. In general, the inversion is carried out assuming a stratified media of homogeneous isotopic layers. This assumption maybe invalid as the shallow subsurface bellow the ocean bottom may be anisotropic. Compaction and particle alignment can produce vertical transverse isotropy in loose sediments. Obtaining anisotropic elastic properties of the near seabed is important for engineering, environmental, and geophysical exploration purposes. Herein we present a multimode anisotropic joint Scholte- and Love-wave inversion and demonstrate it one a synthetic and a field example.
Voltage-gated calcium channels (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database (2020)

Calcium (Ca2+) channels are voltage-gated ion channels present in the membrane of most excitable cells. The nomenclature for Ca2+channels was proposed by [120] and approved by the NC-IUPHAR Subcommittee on Ca2+ channels [68]. Ca2+ channels form hetero-oligomeric complexes. The α1 subunit is pore-forming and provides the binding site(s) for practically all agonists and antagonists. The 10 cloned α1-subunits can be grouped into three families: (1) the high-voltage activated dihydropyridine-sensitive (L-type, CaV1.x) channels; (2) the high-voltage activated dihydropyridine-insensitive (CaV2.x) channels and (3) the low-voltage-activated (T-type, CaV3.x) channels. Each α1 subunit has four homologous repeats (I-IV), each repeat having six transmembrane domains and a pore-forming region between transmembrane domains S5 and S6. Voltage-dependent gating is driven by the membrane spanning S4 segment, which contains highly conserved positive charges that respond to changes in membrane potential. Many of the α1-subunit genes give rise to alternatively spliced products. At least for high-voltage activated channels, it is likely that native channels comprise co-assemblies of α1, β and α2-δ subunits. The γ subunits have not been proven to associate with channels other than the α1s skeletal muscle Cav1.1 channel. The α2-δ1 and α2-δ2 subunits bind gabapentin and pregabalin.
Printed Graphene Electrochemical Biosensors Fabricated by Inkjet Maskless Lithography for Rapid and Sensitive Detection of Organophosphates (2018)

Solution phase printing of graphene-based electrodes has recently become an attractive low-cost, scalable manufacturing technique to create in-field electrochemical biosensors. Here we report a graphene-based electrode developed via Inkjet Maskless Lithography (IML) for the direct and rapid monitoring of triple-O linked phosphonate organophosphates (OPs); these constitute the active compounds found in chemical warfare agents and pesticides that exhibit acute toxicity as well as long-term pollution to soils and waterways. The IML printed graphene electrode is nano/microstructured with a 1000 mW benchtop laser engraver and electrochemically deposited platinum nanoparticles (dia. ~25 nm) to improve its electrical conductivity (sheet resistance decreased from ~10 000 Ω/sq. to 100 Ω/sq.), surface area, and electroactive nature for subsequent enzyme functionalization and biosensing. The enzyme phosphotriesterase (PTE), also known as organophosphate hydrolase (OPH), was conjugated to the electrode surface via glutaraldehyde cross-linking. The resulting biosensor was able to rapidly measure (5 sec response time) the insecticide paraoxon (a model organophosphate) with a low detection limit (3 nM), and high sensitivity (370 nA/µM) with negligible interference from similar nerve agents. Moreover, the biosensor exhibited high reusability (average of 0.3% decrease in sensitivity per sensing event), stability (90% anodic current signal retention over 1000 seconds), longevity (70% retained sensitivity after 8 weeks), and the ability to selectively sense OP in actual soil and water samples. Hence, this work presents a scalable printed graphene manufacturing technique that can be used to create OP biosensors that are suitable for in-field applications as well as, more generally, for low-cost biosensor test strips that could be incorporated into wearable or disposable sensing paradigms.
<title>Development of the next-generation document reader: Eye Scanner</title> (2002)

Up to now a copying machine requires setting the document to the copy glass of the designated position. In addition to that, the copying machine of the present cannot copy the non-flat shape document (e.g. books, cylindrical objects, etc.) clearly. Besides, it cannot copy without distortion. So, we propose a next generation's document reader 'Eye Scanner.' The Eye Scanner is composed of the range finder, digital camera and pan-tilt stage system. Due to these devices the Eye Scanner is possible shape information and high-density texture image acquisition. Therefore the Eye Scanner is able to read the document by the free viewpoint and able to generate the image which is not distorted by the geometric conversion. Moreover, the Eye Scanner has the ability for high-resolution image generation by the digital camera, which placed on the optical coaxial position by the half-mirror. In this paper, we explain about the detail of the system. At the explanation of the methodology we explain the methodology about distortion correction by the free form transformation with shape information and explain about the technique of image merging. At the experiment, we show some result of distortion correction and show the result of image merging.
Experimental study of water-in-oil droplet micro-explosion using LIF measurements : effect of radiative heating configuration (2022)

International audience
Swim exercise in C. elegans extends neuromuscular and intestinal healthspan, enhances learning ability, and protects against neurodegeneration (2019)

Abstract Exercise can protect against cardiovascular disease, neurodegenerative disease, diabetes, cancer, and age-associated declines in muscle, immune, and cognitive function. In fact, regular physical exercise is the most powerful intervention known to enhance robustness of health and aging. Still, the molecular and cellular mechanisms that mediate system-wide exercise benefits remain poorly understood, especially as applies to “off target” tissues that do not participate directly in training activity. Elaborating molecular mechanisms of whole-animal exercise benefits is therefore of considerable importance to human health. The development of exercise protocols for short-lived genetic models holds great potential for deciphering fundamental mechanisms of exercise trans-tissue signaling during the entire aging process. Here, we report on the optimization of a long-term swim exercise protocol for C. elegans and we demonstrate its benefits to diverse aging tissues, even if exercise occurs only during a restricted phase during early adulthood. We found that multiple daily swim sessions are essential for exercise adaptation in C. elegans , leading to body wall muscle improvements in structural gene expression, locomotory performance, and mitochondrial morphology. Swim exercise training enhances whole-animal health parameters such as mitochondrial respiration and mid-life survival and increases the functional healthspan of pharynx and intestine. Importantly, we show that swim exercise also enhances nervous system health: exercise increases learning ability of adult animals and protects against neurodegeneration in C. elegans models of tauopathy, Alzheimer’s disease, and Huntington’s disease. An important point is that swim training only during C. elegans early adulthood induces long-lasting systemic benefits that in several cases are still detectable well into mid-life. Overall, our data reveal the broad impact of swim exercise in promoting extended healthspan of multiple C. elegans tissues, underscore the potency of early exercise experience to influence long-term health (even after cessation of exercise), and establish the foundation for exploiting the powerful advantages of this genetic model to dissect the exercise-dependent molecular circuitry that confers long-lasting system-wide health benefits to aging or diseased adults.
Phase-pure two-dimensional FexGeTe2 magnets with near-room-temperature TC (2021)

Two-dimensional (2D) ferromagnets with out-of-plane (OOP) magnetic anisotropy are potential candidates for realizing the next-generation memory devices with ultra-low power consumption and high storage density. However, a scalable approach to synthesize 2D magnets with OOP anisotropy directly on the complimentary metal-oxide semiconductor (CMOS) compatible substrates has not yet been mainly explored, which hinders the practical application of 2D magnets. This work demonstrates a cascaded space confined chemical vapor deposition (CS-CVD) technique to synthesize 2D FexGeTe2 ferromagnets. The weight fraction of iron (Fe) in the precursor controls the phase purity of the as-grown FexGeTe2. As a result, high-quality Fe3GeTe2 and Fe5GeTe2 flakes have been grown selectively using the CS-CVD technique. Curie temperature (TC) of the as-grown FexGeTe2 can be up to ∼ 280 K, nearly room temperature. The thickness and temperature-dependent magnetic studies on the Fe5GeTe2 reveal a 2D Ising to 3D XY behavior. Also, Terahertz spectroscopy experiments on Fe5GeTe2 display the highest conductivity among other FexGeTe2 2D magnets. The results of this work indicate a scalable pathway for the direct growth and integration of 2D ternary magnets on CMOS-based substrates to develop spintronic memory devices.
Abstract 17496: IL2 Soluble Receptor and Neopterin Levels in Peripartum Cardiomyopathy and Recent Onset Cardiomyopathy in Non-Peripartum Women and Men (2011)

Introduction: IL2 soluble receptor (IL2Rs) and neopterin (NPT) are peripheral markers of T cell and monocyte activation investigated extensively in auto-immune disorders. We assessed these biomarkers in subjects with non ischemic cardiomyopathy of recent onset (ROCM) from the IMAC2 (Intervention in Myocarditis and Acute Cardiomyopathy) registry. We compared the degree of cellular activation in peripartum cardiomyopathy (PPCM) with that evident in non-peripartum women and men with ROCM. Methods: 130 subjects were investigated: 96 subjects with ROCM including 37 women with PPCM (group 3), 27 non-peripartum women (group 2) and 32 men (group 1), and 34 controls without cardiac disease (CTL). All subjects with ROCM had serum obtained at entry and an assessment of LVEF by transthoracic echocardiography. LVEF was reassessed 6 months after enrollment. Results: The ROCM cohort (n=96, 64F/32M, mean age 30±6) had a mean LVEF at baseline of 0.24±0.08 which increased to 0.43±0.13 at 6 months. For controls (mean age 45±6, 24F/10M) the mean LVEF was 0.58±0.10. Both IL2Rs and NPT were markedly elevated in ROCM subjects compared to controls (IL2Rs: ROCM=1411±671, CTL=970±329 pg/ml, p&lt;0.001; NPT: ROCM=9.2±5.6, CTL=6.2±3.1 nmol/l, p=0.003). Increased NYHA class was associated with higher serum levels for both NPT (p=0.013) and IL2Rs (p=0.009). No differences were evident in subjects with PPCM versus men and women with ROCM for either IL2Rs (group 1/2/3 =1524±504/1531±904/1225±566 pg/ml, p=0.10) or NPT (group 1/2/3=9.4±6.5 /9.3±5.8 /8.9±4.7 nmol/l, p=0.92). IL2Rs levels were lower in black subjects: blacks (n=25) IL2Rs=1123±496; whites (n=71) 1513±698, p=0.012. Levels of IL2Rs and NPT did not predict the degree of recovery at 6 months, although there was a nonsignificant trend towards more recovery with lower IL2Rs levels. Conclusions: Marked elevation of IL2Rs and NPT, biomarkers of cellular immune activation, are evident in subjects with ROMC. The degree of activation in subjects with PPCM appears similar to that seen in men and non-peripartum women with ROCM, suggesting similar inflammatory pathogenesis for these syndromes of acute heart failure. The relationship of cellular activation to myocardial injury and recovery in ROCM should be further investigated.
<I>Alu</I>-LTR Real-Time Nested PCR Assay for Quantifying Integrated HIV-1 DNA (2005)

An improved Alu-long terminal repeat (LTR) polymerase chain reaction (PCR) assay is described for the quantification of integrated HIV-1 DNA in infected cells. The method includes generation of an infected cell line containing numerous randomly distributed HIV-1 integrated DNA for the construction of the DNA standard and a two-step real-time PCR assay in which the first-round PCR amplifies the DNA sequence between the HIV-1 LTR and the nearest chromosomal Alu element, and the nested PCR specifically amplifies PCR products from the first-round PCR. This assay allows us to quantify proviral DNA with both accuracy and high sensitivity (six proviruses within 50,000 cell equivalents) and exhibits a broad range of quantification spanning 5 log10 provirus copies. This Alu-LTR-based real-time nested PCR assay may be particularly useful to quantify integrated HIV-1 DNA in patients. It may also allow for the precise study of integration of HIV-1 DNA or HIV-1 based lentiviral vectors and may be a valuable tool to test future inhibitors of integration.
Electrically conducting polymers: arsenic pentafluoride-doped poly(phenylenevinylene) and its analogs (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrically conducting polymers: arsenic pentafluoride-doped poly(phenylenevinylene) and its analogsK. D. Gourley, C. P. Lillya, J. R. Reynolds, and James C. W. ChienCite this: Macromolecules 1984, 17, 5, 1025–1033Publication Date (Print):May 1, 1984Publication History Published online1 May 2002Published inissue 1 May 1984https://pubs.acs.org/doi/10.1021/ma00135a009https://doi.org/10.1021/ma00135a009research-articleACS PublicationsRequest reuse permissionsArticle Views272Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Approach for reducing resist footing over nonplanar wafer (2004)

We have studied the lithography issue of resist footing in an ion implant layer after a gate conductor formation. In a previous report , we proposed the shadow model and showed a solution to reduce the resist footing. This paper reports on the further investigation into the cause and the reduction method of the resist footing over non-planar wafer with simulation and explains the effects with the shadow model. We analyzed the processes that affected the resist footing and four main effects were selected. These were NA, illumination coherency, mask bias, and mask type. We simulated these four effects on an orthogonal array by using the design of experiments (DOE). We obtained a better condition of higher NA, smaller coherency, positive mask bias, and Att-PSM for reducing the resist footing. We explain the reasons for these effective factors with the shadow model.
New perspectives in hypertension research. Potentials of vascular biology. (1994)

The vessel wall was once considered to be a passive conduit responding to the circulating endocrine system. However, the emergence of molecular and vascular biology in hypertension research has redefined our understanding of the role of the vasculature as a vital organ in the pathogenesis of hypertension. It is now recognized that the vasculature can regulate its own tone by a variety of previously unknown autocrine and/or paracrine vasoactive systems. Recent evidence indicates that the process of vascular remodeling in hypertension appears to be mediated by locally generated factors within the vessel wall. This review examines the implications of this new paradigm in hypertension, focusing on five topics that have developed through the emergence of molecular vascular biology: the discovery and characterization of novel biologically active molecules synthesized by the vessel wall, the molecular mechanisms and consequences of vascular remodeling, the developmental biology of the blood vessel and the relation to pathobiology, the use of in vivo gene transfer to test hypotheses in vivo, and novel treatment strategies based on gene therapy of the vessel wall.
ChemInform Abstract: Olefin Metathesis and Beyond (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Polyamine biosynthesis is required for the maintenance of peripheral blood cell elements in the rat. (1983)

The specific ornithine decarboxylase inhibitor alpha-difluoromethylornithine, when given to adult rats in vivo for 5 wk, resulted in a decrease in peripheral blood cell elements in normal rats and a marked suppression of marrow recovery in rats with chemotherapy-induced marrow hypoplasia. In normal rats, alpha-difluoromethylornithine resulted in a reduction of the leukocyte count to 73% of control, erythrocyte count to 61% of control, and platelet count to 24% of control. The bleeding time was increased to twice normal and 67% of the animals had epistaxis and 42% had melena. In rats treated with the S phase-specific chemotherapeutic agent 1-beta-D-arabinofuranosylcytosine, the simultaneous administration of alpha-difluoromethylornithine prevented the recovery of the bone marrow. The peripheral blood cell counts remained low--leukocyte count was 10% of control, and erythrocyte and platelet counts were 6% of control. All the animals developed epistaxis and melena and there was a 72% mortality. The administration of putrescine (4 mmol/kg, intraperitoneally, daily), the specific polyamine product of ornithine decarboxylase, reversed these hematologic effects in both normal and recovering marrow and resulted in rapid clinical improvement. Thus, the maintenance of normal, adult rat hematologic parameters, as with the proliferation of neoplastic and transformed cells in culture, is critically dependent on continued polyamine biosynthesis.