gebhart/patrepeval huggingface dataset:
Intelligent motor control centers: Defining the benefits to petroleum and chemical industries (2017)

As technology continues to drive innovations, petroleum and chemical enterprises must continue to keep pace to remain competitive in an ever-changing marketplace. The technology trend is to replace systems of yesterday with higher-performance, low-cost, option-rich, networked systems that provide a shorter return on investment and offer more flexibility. As control system technology evolves, systems migrate toward functions that are being increasingly distributed to smarter, more granular, control system components capable of performing localized operations. Most of these functions were once the responsibility of a central or master controller. Systems that integrate intelligent devices, device-level networks, and reporting software into medium-voltage (MV) and low-voltage (LV) motor control centers are a prime example where this trend is increasingly implemented. Technology can deliver improved diagnostics, early warnings used to increase system reliability, design flexibility, simplified and reduced wiring, and additional levels of protection for personnel safety in all process industries via the utilization of intelligent networks. This paper focuses on the next steps of technology integration, intelligent devices, and device level information collection over a single network that provides the convergence of control and information to optimize plant and enterprise wide processes and energy management.
Carrier dynamics in nitride-based light-emitting p-n junction diodes with two active regions emitting at different wavelengths (2003)

The carrier transport and recombination dynamics of monolithic InGaN/GaN light-emitting p-n junction structures with two active regions are investigated. Room-temperature and low-temperature photoluminescence and room-temperature electroluminescence measurements show two emission bands originating from the two active regions. In electroluminescence, the intensity ratio of the two emission bands is independent of injection current. In contrast, the intensity ratio depends strongly on the excitation intensity in photoluminescence measurements. The dependency of the emission on excitation is discussed and attributed to carrier transport between the two active regions and to the different carrier injection dynamics in photoluminescence and electroluminescence. The luminous efficacy of a Gaussian dichromatic white-light source is calculated assuming a line broadening ranging from 2kT to 10kT. Luminous efficacies ranging from 380 to 440 lm/W are obtained for broadened dichromatic sources.
Energy-Efficient Transmission for Protection of Incumbent Users (2011)

Cognitive radio (CR) technology can be used to provide flexible mobile multimedia communications. In this article, we investigate energy-efficient design of CR to protect incumbent users, such as broadcasters and telecommunications operators. Power allocation and transmission duration are determined for a CR user exploiting multiple channels. Both energy efficiency of the CR user and interference with the incumbent users are considered. Simulation results demonstrate that the proposed approaches achieve reliable protection and significant performance gain in terms of energy efficiency.
Combined effect of early life stress and acute stress on colonic sensory and motor responses through serotonin pathways: Differences between proximal and distal colon in rats (2011)

Clinically, adults who have experienced stresses in childhood present with episodes of serious symptoms of irritable bowel syndrome that are associated with acute stress, but the mechanism is not well understood. This study aimed to investigate the colonic sensory/motor responses to acute water avoidance stress (WAS) in male adult rats subjected to neonatal maternal separation (NMS), and the underlying mechanism of sensory/motor responses. Effects of the combined acute and early life stress on visceral sensation, colonic motility, and the tissue and luminal content of serotonin (5-hydroxytryptamine, 5-HT) in the proximal and distal colon were evaluated using the abdominal withdrawal reflex test, faecal pellet output measurement and capillary electrophoresis analysis, respectively. Results showed that WAS significantly increased not only visceral sensitivity but also colonic motility in NMS rats compared to the normal rats. These alterations were accompanied by significant increase in 5-HT content in the proximal but not the distal colonic tissues; these alterations were also associated with increased density of enterochromaffin (EC) cells in the proximal segment. In contrast, the faecal content of 5-HT increased similarly in both segments. Consecutive administration of parachlorophenylalanine to NMS rats was more potent at 500 mg kg⁻¹ day⁻¹ than at 150 mg kg⁻¹ day⁻¹ in suppressing colonic sensory/motor responses to WAS, corresponding to the greater reduction of the tissue and faecal content of 5-HT and of EC cell density in the colon. These data indicate that combined early life stress and acute stress effectively induce visceral hyperalgesia and motility disorder through 5-HT pathways in the colon of rats, and the proximal and distal colon have different responses towards the combined stressors.
ChemInform Abstract: Influence of Steric Parameters on the Synthesis of Tetramates from α‐Amino‐β‐alkoxy‐esters and Ph3PCCO. (2012)

Abstract The domino addition—Wittig cyclization sequence produces enantiomerically pure tetramate structures.
Supplementary Table 1 from Progressive Chromatin Repression and Promoter Methylation of <i>CTNNA1</i> Associated with Advanced Myeloid Malignancies (2023)

Supplementary Table 1 from Progressive Chromatin Repression and Promoter Methylation of &lt;i&gt;CTNNA1&lt;/i&gt; Associated with Advanced Myeloid Malignancies
Cytogenetic Effects of Grape Extracts (Vitis vinifera) and Polyphenols on Mitomycin C-Induced Sister Chromatid Exchanges (SCEs) in Human Blood Lymphocytes (2007)

In the present study, the effects of extracts and polyphenol-rich fractions as well as monomer polyphenols identified in them, from both red and white grapes, on mitomycin C (MMC) induced sister chromatid exchanges (SCEs) in human peripheral blood lymphocytes were investigated. The grape extracts and two of the three polyphenol-rich fractions promoted MMC-induced SCEs at concentrations from 75 to 300 microg/mL. However, none of the extracts or fractions alone induced SCEs. Thus, these results suggest caution especially with regard to the use of grape extracts as dietary supplements. On the other hand, the fact that these extracts were not genotoxic alone may indicate a selective activity against genetically damaged cells. This is the first study regarding the clastogenic effects of grape extracts in human cells. Moreover, from the tested polyphenols, caffeic acid, gallic acid, and rutin hydrate enhanced MMC-induced clastogenicity, whereas ferulic acid, protocatechuic acid, (+)-catechin, (-)-epicatechin, and trans-resveratrol had no effect at concentrations between 5 and 100 microM. The differences in the chemical structures of the tested polyphenols may account for their differential effects on MMC clastogenicity.
Comparison of Three Glycoproteomic Methods for the Analysis of the Secretome of CHO Cells Treated with 1,3,4-O-Bu3ManNAc (2020)

Comprehensive analysis of the glycoproteome is critical due to the importance of glycosylation to many aspects of protein function. The tremendous complexity of this post-translational modification, however, makes it difficult to adequately characterize the glycoproteome using any single method. To overcome this pitfall, in this report we compared three glycoproteomic analysis methods; first the recently developed N-linked glycans and glycosite-containing peptides (NGAG) chemoenzymatic method, second, solid-phase extraction of N-linked glycoproteins (SPEG), and third, hydrophilic interaction liquid chromatography (HILIC) by characterizing N-linked glycosites in the secretome of Chinese hamster ovary (CHO) cells. Interestingly, the glycosites identified by SPEG and HILIC overlapped considerably whereas NGAG identified many glycosites not observed in the other two methods. Further, utilizing enhanced intact glycopeptide identification afforded by the NGAG workflow, we found that the sugar analog 1,3,4-<i>O</i>-Bu<sub>3</sub>ManNAc, a "high flux" metabolic precursor for sialic acid biosynthesis, increased sialylation of secreted proteins including recombinant human erythropoietin (rhEPO).
The Increase of Mitochondrial DNA Copy Number Attenuates Eccentric Cardiac Remodeling In Volume Overload Model (2013)

Background Mitochondrial transcription factor A (TFAM) is essential for the maintenance of mitochondrial DNA (mtDNA). TFAM overexpression increases mtDNA copy number, prevents cardiac remodeling and improves survival after myocardial infarction. However, the role of the increased mtDNA copy number in volume overload (VO) remains unknown. Methods and Results We used TFAM and Twinkle (TW) transgenic (TG) mice, both of which nearly doubled the mtDNA copy number in heart. One day after creating the aortocaval shunt to induce VO, left ventricular (LV) end diastolic pressures equally increased in all groups, and TFAM and TW significantly suppressed increased mRNAs of matrix metalloprotease (MMP) ‐9 and connective tissue growth factor. In 8 weeks after operation, both TFAM and TW prevented LV dysfunction (LV ejection fraction: TFAM 53.6±2.5, TW 54.0±1.0, WT 37.1±1.9, 39.1±3.0, p&lt;0.01), dilatation (LV diastolic dimension: TFAM 4.6±0.1, TW 4.3±0.1, WT 5.0±0.1, 4.9±0.1, p&lt;0.01) and perivascular fibrosis. They also suppressed superoxide (TFAM −21%, TW −31% vs. each wild type VO group, p&lt;0.05) and MMP activity (TFAM −31%, TW −23% vs. each wild type VO group, p&lt;0.05). Conclusion Overexpressed TFAM or TW equally ameliorated VO‐induced eccentric cardiac remodeling, which suggests that increased mtDNA copy number plays a key role in anti‐remodeling effects of TFAM and TW via suppression of MMP activity and fibrosis.
Spectrum measurement of the cavity-QED microlaser: Deviation from the Schawlow-Townes linewidth (2010)

We report the measurement of the cavity-QED microlaser linewidth near threshold by using the photon-counting-based second-order correlation spectroscopy. The abrupt rise-and-fall of the linewidth near thereshold is observed.
[The characteristic of diarrheagenic Escherichia separated from children aged under 5 years old in Yaroslavl.] (2019)

The diarrheagenic bacteria coli take a significant place among agents of acute intestinal infections in children aged under 5 years. The main danger among these pathogens is represented by both enterotoxigenic E. coli causing enteritis and enterocolitis accompanied by acute dehydration diarrhea and Escherichia producing shiga-toxin being agents of hemorrhagic colitis and hemolytic uremic syndrome. The fast and proper identification of agents of these two groups of pathogens is an important task of bacteriologists to be resolved for successful treatment of patient because tactics of therapy of enterotoxigenic diarrhea and hemorrhagic colitis and hemolytic uremic syndrome significantly differ. The high capacity of Escherichia coli to form populations resistant to anti-microbial medications, including pan-resistant ones, also is a serious problem for science and public health. The object of study was a collection of isolates of E. coli (n = 112), separated from 112 children aged under 5 years with clinical manifestations of acute intestinal infection, food toxic infection hemocolitis and diarrhea of obscure etiology in Yaroslavl in 2015-2017. Initially, the strains of E. coli were tested using diagnostic agglutinating coli-serums and then using reagents' kit «AmpliSens®Escherichiosis-FL» for detection and differentiation DNAof diarrheagenic bacteria coli and also with specific oligonucleotide primers to genes of virulence and O-serum group belonging. The obtained data permitted to determine belonging of analyzed strains of E. coli to four sub-groups: ЕНЕС (n = 9), EPEC (n = 17), ETEC (n = 1) и EAgEС (n = 1). All of them were agents of genes of pathogenicity specific for every pathogroup. The most numerous group EPEC was represented by strains of five serogroups with dominating among them serogroup O26 (9 strains). Therefore, studying collection of strains of diarrheagenic Escherichia isolated during 2015-1017 in Yaroslavl from children aged under 5 years with acute intestinal infections permitted to demonstrate efficiency of application of molecular genetic methods of analysis for characterizing E. coli i.e. establishment their serogroups, detection of genes of virulence and attributing to pathogroups.
Micropower integrated circuits for an implantable bidirectional blood flowmeter (1976)

The measurement of bidirectional bloodflow on a chronic basis is of critical importance in research on cardiovascular and pulmonary diseases. An implantable bidirectional Doppler ultrasonic bloodflow system was designed to satisfy this need. The system utilized quadrature detection to provide the directional information and multiplexing to transmit the quadrature signals over one FM telemetry link. A new family of three 1 V micropower bipolar integrated circuits were designed to implement the RF amplifiers, square law detectors, /spl plusmn//spl pi//4 phase shifters, audio amplifiers, a multiplexer, and the FM transmitter required for this system. An implanted system was used to measure pulsatile bidirectional bloodflow on a canine descending aorta. The results compared well with those in the literature and with a percutaneous EM flowmeter.
Electrodeposition of Corrosion‐Resistant Ni‐Zn Alloy: I . Cyclic Voltammetric Study (1993)

The interaction between different reacting species involved in the initial stage of electrodeposition of nickel‐zinc alloy was investigated. A cyclic voltammetric study indicates that codeposition of hydrogen and nickel occurs, with formation of two types of hydrogen‐nickel solid solution, i.e., β‐Ni and α‐Ni. This nickel hydride formation during Ni‐Zn alloy electrodeposition was verified by analyzing the voltammograms of nickel, zinc, and Ni‐Zn alloy during initial deposition on various substrates. The dissolution potential of zinc and nickel from electrodeposited nickel‐zinc alloy spans a wide range (ca. 400 mV). The influence of the interaction between nickel, hydrogen, and zinc on the nucleation of nickel‐zinc electrodeposition is reported in part II of this paper, p. 1304.
Resolving discrete emission events: A new perspective for detrapping investigation in NAND Flash memories (2013)

We report the first experimental evidence of discrete threshold-voltage transients on high-density NAND Flash arrays during post-cycling data retention. Proper choice of experimental conditions eliminates the impact of averaging effects and disturbs on the transients, enabling clear detection of single charge emission events from/to the tunnel oxide of sub-30nm NAND Flash cells. A stochastic model for the discrete emission process was developed from experimental data, demonstrating that number fluctuation of charges trapped in the tunnel oxide and the statistical nature of their emission dynamics strongly affect the post-cycling data retention performance of the arrays. These results pave the way for further analyses of NAND Flash reliability, where the behavior of single electrons and defects can be monitored and facilitate detailed assessments of the fundamental scaling challenges arising from the discrete nature of charge trapping/detrapping.
Characterization of interface reflection coefficients using a finite-difference injection technique (2017)

In this paper, a numerical wave field injection technique for characterizing the reflection coefficient of a planar medium interface is proposed. By injecting recorded wave field quantities into a three-dimensional (3D) finite-difference calculation, two key objectives are addressed: first, the recorded wave field is separated into its incident and reflected constituents without the need of spatial Fourier transforms or a temporal separation of incident and reflected parts in the recorded data. Second, the separated constituents are independently extrapolated to the location of the reflecting interface to determine its reflecting properties. The methodology is experimentally validated on 3D laboratory data consisting of reflections from the water-air interface in a water tank and is shown to give accurate results for incidence angles of up to 60°.
PHENOTYPE-DEPENDENT AND INDEPENDENT INERTIAL FOCUSING (2011)

The ability to precisely position flowing particles in microchannels would aid development of clinically useful cell identification and purification technologies. Here, we investigated the effect of fluid inertia on lateral focusing positions of flowing deformable cells over a wide range of flow rates. It was found that, at lower flow rates, cells can be differentially positioned in the lateral direction based on deformability variations, while, at higher flow rates fluid inertia dominates and all cell types, regardless of their mechanical properties, were more uniformly positioned. The presented study provides improved design criteria for high-throughput cell manipulation system development.
Designed fabrication of active tumor targeting covalent organic framework nanotherapeutics via a simple post-synthetic strategy (2023)

Developing agents that can accurately differentiate tumors from normal healthy tissues is of utmost importance for safe cancer therapy. Active targeting has been considered as an effective technique for tumor recognition. In this work, we demonstrate a folate-functionalized nanoscale covalent organic framework (FATD nCOF) highly specific to cancer cells through active targeting of their enriched folate receptors (FRs). The FATD nCOF prepared by simple post-synthetic modification of the COF surface defeats disperses well in water and exhibits a high loading capacity for various anticancer drugs. The biocompatible FATD nCOF is selectively internalized by FR-harboring cancer cells and consequently augments the efficacy of the loaded drug, Withaferin A (Wi-A), for targeted cancer cell killing. In biomolecular mechanism studies, Wi-A-loaded FATD (FATD@Wi-A) nanocomposites show remarkably a higher rate of apoptosis in FR-enriched cancer cells. Comparative analyses of FR-positive and FR-negative tumor xenografts reveal enhanced selective antitumor activity of FATD@Wi-A nanotherapeutics. Taken together, the study findings suggest that FATD nCOF holds great promise for active targeting of tumors in vivo. Our simple yet effective technology might be valuable for creating new state-of-the-art COFs for chemical and biomedical applications.
THE ABILITY OF BONE GRAFT SUBSTITUTES TO SUPPORT MESENCHYMAL OSTEOPROGENITOR CELLS. AN IN VITRO STUDY (2012)

Aim To compare a variety of commercially available bone graft substitutes (BGS) in terms of promoting adherence, proliferation and differentiation of osteoprogenitor cells. Materials and methods A fixed number of porcine mononuclear cells obtained from cancellous bone of the proximal femur was mixed with a standard volume of BGS and then cultured for one week in media followed by two weeks in osteogenic media. BGS included commercially available β-Tricalcium Phosphate (□-TCP), highly porous β-TCP, Hydroxyapatite/Tricalcium phosphate composite, calcium sulphate (CS), Hydroxyapatite (HA), Demineralised bone matrix (DBM), polygraft, and polymers (PGA, PLGA). Staining for live/dead cells as well as scanning electron microscopy (SEM) were carried out on all samples to determine viability and cellular binding. Further outcome measures included alkaline phosphatase assays with normalisation for DNA content to quantify osteogenic potential. Negative (BGS without cells) and positive (culture expanded osteoprogenitors) control experiments were carried out in parallel to validate the results. Results Live/dead and SEM imaging showed higher cellular viability and attachment with β-TCP than with other BGS. In the experimental setup the average alkaline phosphatase activity in nmol/ml (normalised value for DNA content in nmol/μg DNA) per sample was 657.58 (132.03) for β-TCP, 36.22 (unable to normalise) for calcium sulphate, 19.93 (11.39) for the HA/ TCP composite, 14.79 (18.53) for polygraft, 13.98 (8.15) for the highly porous β-TCP, 5.56 (10.0) for PLGA, 3.82 (3.8) and for HA. It was not possible to analyse data for either DBM or PGA. Conclusion Under theses experimental conditions, β-TCP has apparent favourable characteristics in terms of maintaining viability of osteoprogenitor cells and allowing proliferation and differentiation. Further work will be carried out to characterise the effect that BGS have on osteoprogenitor cells.
Asymmetric Hydrocyanation of Hydrazones Catalyzed by Lanthanide−PYBOX Complexes (2003)

[reaction: see text] The asymmetric addition of HCN to hydrazones is catalyzed in high yield and good-to-excellent enantioselectivity by the easily prepared (PhPYBOX)ErCl3 complex. This constitutes the first example of asymmetric catalytic hydrocyanation of hydrazones.
Classification of patient movement events captured with a 6-axis inertial sensor (2015)

Patient monitoring is an important part of the overall treatment plan for hospital in-patients. However, monitoring is often time consuming for hospital staff. Staff must either remain in a patient's room, check in on the patient with frequent intervals or remotely monitor the patient via video surveillance. Constant monitoring may be disruptive to the patient as he or she attempts to rest. Furthermore, all of these methods may be considered intrusive to the patient's privacy and time-consuming for hospital staff which may result in increased medical costs. To mitigate these issues, we propose an alternate method of patient monitoring wherein a high-sensitivity 6-axis accelerometer is attached to the patient's hospital bed. Using frequency-series analysis, we can extract relevant patterns for patient movement and train a classifier to identify movement patterns of the patient. Automated monitoring of the patient's movement frees up time for hospital staff. The system can be configured to immediately notify staff when certain events are detected, thereby directing resources to where they are needed most. Event identification accuracy of 90% for a 12-class problem space was achieved.
Discovery of a Selective, Covalent IRAK1 Inhibitor with Antiproliferative Activity in MYD88 Mutated B-Cell Lymphoma (2020)

Interleukin 1 (IL-1) receptor-associated kinases (IRAKs) are serine/threonine kinases that play critical roles in initiating the innate immune response against foreign pathogens. Additionally, dysregulation of IRAK1 signaling plays a role in neoplastic disorders. For example, IRAK1 was shown to be important for survival and proliferation in many B-cell lymphomas, including Waldenström's macroglobulinemia (WM) and ABC subtype Diffused Large B-cell Lymphoma (DLBCL) cells. Here, we report the discovery of a highly potent and selective covalent inhibitor of IRAK1, JH-X-119-01. Intact protein MS labeling studies confirmed that JH-X-119-01 irreversibly labels IRAK1 at C302. This compound exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88. Cotreatment of JH-X-119-01 with the BTK inhibitor ibrutinib resulted in synergistic killing effects in these systems. Taken together, JH-X-119-01 represents a highly selective probe of IRAK1 for further development.