gebhart/patrepeval huggingface dataset:
Metal Composition and Polyethylenimine Doping Capacity Effects on Semiconducting Metal Oxide–Polymer Blend Charge Transport (2018)

Charge transport and film microstructure evolution are investigated in a series of polyethylenimine (PEI)-doped (0.0-6.0 wt%) amorphous metal oxide (MO) semiconductor thin film blends. Here, PEI doping generality is broadened from binary In<sub>2</sub>O<sub>3</sub> to ternary (e.g., In+Zn in IZO, In+Ga in IGO) and quaternary (e.g., In+Zn+Ga in IGZO) systems, demonstrating the universality of this approach for polymer electron doping of MO matrices. Systematic comparison of the effects of various metal ions on the electronic transport and film microstructure of these blends are investigated by combined thin-film transistor (TFT) response, AFM, XPS, XRD, X-ray reflectivity, and cross-sectional TEM. Morphological analysis reveals that layered MO film microstructures predominate in PEI-In<sub>2</sub>O<sub>3</sub>, but become less distinct in IGO and are not detectable in IZO and IGZO. TFT charge transport measurements indicate a general coincidence of a peak in carrier mobility (μ<sub>peak</sub>) and overall TFT performance at optimal PEI doping concentrations. Optimal PEI loadings that yield μ<sub>peak</sub> values depend not only on the MO elemental composition but also, equally important, on the metal atomic ratios. By investigating the relationship between the MO energy levels and PEI doping by UPS, it is concluded that the efficiency of PEI electron-donation is highly dependent on the metal oxide matrix work function in cases where film morphology is optimal, as in the IGO compositions. The results of this investigation demonstrate the broad generality and efficacy of PEI electron doping applied to electronically functional metal oxide systems and that the resulting film microstructure, morphology, and energy level modifications are all vital to understanding charge transport in these amorphous oxide blends.
Spectrophotometric Detection of Trace Copper Levels in Jet Fuel (2002)

To sensitively and selectively monitor jet fuel for trace levels of copper, two spirobenzopyran dyes, quinolinospiropyranindoline (QSP) and nitrospiropyranindoline (NQSP), have been investigated for their application in a spectrophotometric method that is amenable to rapid, on-site detection of μg/L levels of copper in jet fuel. Both NQSP and QSP respond sensitively to various metal ions in jet fuel, including copper, nickel, and zinc, with NQSP demonstrating the best performance in terms of selectivity of spectral response and sensitivity. Principal component analysis (PCA) was applied to the spectral data, and the individual contributions to the absorption spectra by copper, nickel, and zinc in JP-5 fuel can be readily separated using this technique. The effect of metal deactivating additives (MDA) in jet fuel on the sensitivity of NQSP for copper was investigated. Silica-bound diethylenetriamine was investigated as an effective solid-phase extraction agent for defining the baseline absorbance of NQSP in jet fuel samples being analyzed by standard addition methodologies.
User Allocation with Round-Robin Scheduling Sequence for Distributed Antenna System (2019)

One of key technologies in the fifth generation mobile communications is a distributed antenna system (DAS). In the DAS inter-user interference effects on its spectrum efficiency as distributed antennas are located closely. Round-robin (RR) scheduling is known as a scheme that achieves a trade-off between computational complexity and spectrum efficiency. In this research user equipment (UE) allocation scheme for RR scheduling are proposed. The proposed scheme determines the phases of UE allocation sequence that is pre-determined for low complexity. Numerical results obtained through computer simulation have shown that maximum selection that sequentially searches the phase with the maximum tentative throughput realizes the largest spectrum efficiency next to full search. The system throughput increases as the number of UEs increases in 2-user RR scheduling.
Temperature, by Controlling Growth Rate, Regulates CRISPR-Cas Activity in Pseudomonas aeruginosa (2018)

Clustered regularly interspaced short palindromic repeat (CRISPR)-associated (CRISPR-Cas) systems are adaptive defense systems that protect bacteria and archaea from invading genetic elements. In <i>Pseudomonas aeruginosa</i>, quorum sensing (QS) induces the CRISPR-Cas defense system at high cell density when the risk of bacteriophage infection is high. Here, we show that another cue, temperature, modulates <i>P. aeruginosa</i> CRISPR-Cas. Increased CRISPR adaptation occurs at environmental (i.e., low) temperatures compared to that at body (i.e., high) temperature. This increase is a consequence of the accumulation of CRISPR-Cas complexes, coupled with reduced <i>P. aeruginosa</i> growth rate at the lower temperature, the latter of which provides additional time prior to cell division for CRISPR-Cas to patrol the cell and successfully eliminate and/or acquire immunity to foreign DNA. Analyses of a QS mutant and synthetic QS compounds show that the QS and temperature cues act synergistically. The diversity and level of phage encountered by <i>P. aeruginosa</i> in the environment exceed that in the human body, presumably warranting increased reliance on CRISPR-Cas at environmental temperatures.<b>IMPORTANCE</b><i>P. aeruginosa</i> is a soil dwelling bacterium and a plant pathogen, and it also causes life-threatening infections in humans. Thus, <i>P. aeruginosa</i> thrives in diverse environments and over a broad range of temperatures. Some <i>P. aeruginosa</i> strains rely on the CRISPR-Cas adaptive immune system as a phage defense mechanism. Our discovery that low temperatures increase CRISPR adaptation suggests that the rarely occurring but crucial naive adaptation events may take place predominantly under conditions of slow growth, e.g., during the bacterium's soil dwelling existence and during slow growth in biofilms.
PPS-Polymer-Composites for High Performance Rubber Components (2015)

Based on their properties, PPS fibers are a promising material for reinforcing elastomeric components that are subjected to high mechanical and thermal loads. The use of this material is at present hindered because of the low adhesion between the fiber and matrix. Atmospheric pressure plasma treatments based on the dielectric barrier discharge were performed on PPS fibers using air as reactive gas for different treatment durations in order to improve the adhesion. The effects of these treatments have been characterized by determining the surface energy, and the residual tensile strength as well as by analyzing the surface chemistry. Required conditions for an improved wetting behavior and a significant increase in the polar component of the surface energy could then be identified.
Saliva and Sweat Testing With Drugwipe® (2005)

Drugwipe® (Securetec Detektions-Systeme AG) is a pen-size detector for illegal drugs in saliva, in sweat, and on surfaces. It was first launched in 1995 to support drug law-enforcement police in their operations against smuggling and dealing of contraband. In 1996 the US Office for National Drug Control Policy (ONDCP) tested Drugwipe for its accuracy, sensitivity, and specificity in detecting invisible traces of narcotics on surfaces (1). Since then, Drugwipe has been included in the technology transfer program of ONDCP. With the increasing interest in saliva and sweat testing on the part of traffic police, the Drugwipe device has been significantly improved over the years. Today, Drugwipe is available for the detection of cocaine, opiates, cannabinoids, benzodiazepines, and amphetamines/methamphetamines (“ecstasy”). Drugwipe can be used to test oral fluids or sweat samples, or to detect invisible traces of narcotics. Commercially available Drugwipes include single, twin, and five-panel configurations. Drugwipe is especially designed for on-site applications and combines easy and rapid sampling with fast analysis. Drugwipe is used widely in Germany as a routine sweat or saliva test for roadside screening for driving under the influence of drugs (DUID). In the current Roadside Testing Assessment (ROSITA) II project, Drugwipe is under evaluation as a saliva test. The basic technology for analysis is lateral-flow immunoassay (see Chapters 3–6). This chapter will first describe the technological basis of Drugwipe, including its major technical features. The second part will cover the various evaluation studies that have been performed using Drugwipe under controlled and general field conditions. Some of the data are not yet published. Drugwipe can detect various benzodiazepines to as low as 5 ng/mL, and Δ9-tetrahydrocannabinol (THC) can be detected at 30 ng/mL. These sensitivities are currently unique for point-of-collection oral fluid/sweat test kits. The second part of this paper summarizes various published and unpublished data from trials and studies under controlled and general field conditions. Based on 1763 cases, a statistical evaluation by traffic police in Germany shows that more than 97% of all positive Drugwipe sweat tests are confirmed with positive blood results.
Microlamination for Microtechnology-Based Energy, Chemical, and Biological Systems (1999)

Abstract Microlamination is a process for fabricating micro and meso scale systems having intricate arrays of components interconnected within a single block of metal, ceramic, or polymeric material. The process begins by surface machining, or through cutting, individual laminae with patterns containing the desired structure. The laminae are often shims of a base material having desirable mechanical and thermal properties important to the functioning of the final device. Once the patterns are cut, the shims are surface treated and stacked in a prearranged order. Bonding then takes place forming a single laminate. Some post processing of the final part can be performed to dissociate internal structures if needed. This paper describes work being accomplished at Oregon State University on the microlamination process. The paper emphasizes laser micromachining of metal and polymeric laminates. Laser techniques covered include pulsed Nd:YAG-based micromachining at the fundamental and higher harmonics. Also, examples of CO2 laser machining are presented. Process descriptions are provided and examples given of micro and mesoscale components needed for producing devices useful in the energy, chemical, and biological areas.
In Situ Monitoring Drug Effects on Cancer Cell at "Few Cells" Level (2007)

This research is to develop a system to allow cancer researchers as well as drug discovery people to study drug effects <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in situ</i> , <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">real-time</i> and at "few cells" level but large cell numbers. A microelectrode array was designed and fabricated by using silicon micromachining technology. The cancer cell NCI-H460 was attached on the Au microelectrode and the high impedance sensitivity at very "few cells" level has been achieved. The results of the anti-α2β1-integrin effects on NCI-H460 lung cancer cells attachment was first time reported. The results obtained here show a good potential to achieve the single cell attachment detection.
Covid-19 and Immunity in Aging Populations — A New Research Agenda (2020)

Covid-19 and Immunity in Aging Populations As billions of dollars flow into research and development efforts aimed at controlling SARS-CoV-2, the pandemic response remains hamstrung by our limited ...
Supplementary Table 1 from Adjuvant Sirolimus Does Not Improve Outcome in Pet Dogs Receiving Standard-of-Care Therapy for Appendicular Osteosarcoma: A Prospective, Randomized Trial of 324 Dogs (2023)

&lt;p&gt;Supplementary Table 1 contains the inclusion and exclusion criteria for pet dogs considered for enrollment into the SOC and SOC + S clinical trial arms.&lt;/p&gt;
ChemInform Abstract: SYNTHESIS OF OPTICALLY PURE α‐METHYLENE‐Γ‐LACTONES FROM (.+‐.)‐R‐(4‐METHYLPHENYL)ALKYL SULFOXIDES (1985)

Abstract Die sterisch einheitlichen Sulfoxide (I) werden mit Brom‐methacrylsäureester zu (III) substituiert, zu (IV) reduziert und dann über eine Methylierung zu (VI) in sterisch einheitliche Methylenlactone (VII) übergeführt.
<title>HgCdTe multispectral infrared FPAs for remote sensing applications</title> (1998)

Infrared (IR) remote sensing imaging applications require high-performance Focal Plane Arrays (FPAs) operating in all ranges of the IR spectrum. Short wavelength (SWIR; 1 to 3 micrometer), middle wavelength (MWIR; 3 to 5 micrometer), mid- long wavelength (MLWIR; 6 to 8 micrometer), long wavelength (LWIR; 8 to 14 micrometer), and very long wavelength (VLWIR; greater than 14 micrometer). These diverse spectral bands require high performance detectors and Read Out Integrated Circuits (ROICs) to perform the multi-spectral mission requirements. Significant progress in the design and fabrication of HgCdTe detector arrays and Read Out Integrated Circuits (ROICs) over the past few years has led to the demonstration of high resolution, low noise and large format reliable FPAs. Hybrid FPAs have been measured and their performance parameters are presented. Focal Plane Array D* performance values have been obtained for a multitude of spectral ranges and configurations that include; (1) (lambda) <SUB>c</SUB> equals 1.8 micrometer, 12 X 256 arrays operating at 295 K with median D* approximately 1.4 X 10<SUP>12</SUP> cm Hz<SUP>1/2</SUP>/W, (2) (lambda) <SUB>c</SUB> equals 2.4 micrometer, 12 X 256 arrays operating at 250 K with median D* equals 1.6 X 10<SUP>12</SUP> cm Hz<SUP>1/2</SUP>/W, detectors used are grown by MBE on lattice matched CdZnTe, (3) PACE-1 detectors with (lambda) <SUB>c</SUB> equals 2.5 micrometer, 1024 X 1024 arrays operating at 115 K with peak D* of 2.3 X 10<SUP>13</SUP> cm Hz<SUP>1/2</SUP>/W at a background flux (phi) <SUB>b</SUB> equals 1.2 X 10<SUP>11</SUP> ph/cm<SUP>2</SUP>- s, (4) MBE HgCdTe on Silicon MWIR detectors have been fabricated and the detector R<SUB>o</SUB>A performance for (lambda) <SUB>co</SUB> approximately 5.0 micrometer is in the 10<SUP>6</SUP> to 10<SUP>7</SUP> ohm-cm<SUP>2</SUP> range at 78 K. (5) MBE HgCdTe on CdZnTe detectors, ((lambda) <SUB>c</SUB> equals 15.8 micrometer at 65 K), 128 X 128 array operating at 40 K with peak D* of 2.76 X 10<SUP>11</SUP> cm Hz<SUP>1/2</SUP>/W at a background flux (phi) <SUB>b</SUB> equals 8.0 X 10<SUP>15</SUP> ph/cm<SUP>2</SUP>-s. High performance 640 X 480 arrays imaging in the MWIR band have been fabricated on CdZnTe and PACE-1 substrates. The performance of these and additional FPAs will be presented.
Nanoparticle-Mediated Cell Capture Enables Rapid Endothelialization of a Novel Bare Metal Stent (2018)

Incomplete endothelialization of intracoronary stents has been associated with stent thrombosis and recurrent symptoms, whereas prolonged use of dual antiplatelet therapy increases bleeding-related adverse events. Facilitated endothelialization has the potential to improve clinical outcomes in patients who are unable to tolerate dual antiplatelet therapy. The objective of this study was to demonstrate the feasibility of magnetic cell capture to rapidly endothelialize intracoronary stents in a large animal model. A novel stent was developed from a magnetizable duplex stainless steel (2205 SS). Polylactic-co-glycolic acid and magnetite (Fe<sub>3</sub>O<sub>4</sub>) were used to synthesize biodegradable superparamagnetic iron oxide nanoparticles, and these were used to label autologous blood outgrowth endothelial cells. Magnetic 2205 SS and nonmagnetic 316L SS control stents were implanted in the coronary arteries of pigs (n = 11), followed by intracoronary delivery of magnetically labeled cells to 2205 SS stents. In this study, we show extensive endothelialization of magnetic 2205 SS stents (median 98.4% cell coverage) within 3 days, whereas the control 316L SS stents exhibited significantly less coverage (median 48.9% cell coverage, p < 0.0001). This demonstrates the ability of intracoronary delivery of magnetic nanoparticle labeled autologous endothelial cells to improve endothelialization of magnetized coronary stents within 3 days of implantation.
Mass Spectrometric/Bioinformatic Identification of a Protein Subset That Characterizes the Cellular Activity of Anticancer Peptides (2014)

The preclinical study of the mechanism of action of anticancer small molecules is challenging due to the complexity of cancer biology and the fragmentary nature of available data. With the aim of identifying a protein subset characterizing the cellular activity of anticancer peptides, we used differential mass spectrometry to identify proteomic changes induced by two peptides, LR and [d-Gln(4)]LR, that inhibit cell growth and compared them with the changes induced by a known drug, pemetrexed, targeting the same enzyme, thymidylate synthase. The quantification of the proteome of an ovarian cancer cell model treated with LR yielded a differentially expressed protein data set with respect to untreated cells. This core set was expanded by bioinformatic data interpretation, the biologically relevant proteins were selected, and their differential expression was validated on three cis-platinum sensitive and resistant ovarian cancer cell lines. Via clustering of the protein network features, a broader view of the peptides' cellular activity was obtained. Differences from the mechanism of action of pemetrexed were inferred from different modulation of the selected proteins. The protein subset identification represents a method of general applicability to characterize the cellular activity of preclinical compounds and a tool for monitoring the cellular activity of novel drug candidates.
The use of ECT in people with intellectual disability (2013)

Intellectual disability is a descriptive term not a condition in itself and although the number of identifiable disorders that alter neurodevelopment and create an associated intellectual disability is steadily increasing, we are only beginning to understand the many ways in which the altered neural substrate modifies the course and presentation of coexisting psychiatric disorders. Save in the case of relatively common conditions, such as Down syndrome or fragile-X syndrome, studies in intellectual disability usually involve patients with ill-defined, heterogeneous aetiologies grouped on the basis of their degree of intellectual impairment rather than aetiology. It is clear, however, that adults with intellectual disability are susceptible to the whole range of psychiatric disorders seen in the general population. In addition, our understanding of behaviour phenotypes has developed over recent years; this concept has helped us understand some of the links between genetics and behaviour (O'Brien & Yule, 1995). The term intellectual disability is used throughout this chapter because it has been adopted by the Royal College of Psychiatrists and is used internationally. The evidence base in this area of ECT use is composed almost entirely of case reports. The limited nature of this evidence, compounded with specific issues regarding diagnosis and consent, partially explains why ECT seems to be used rarely in people with intellectual disability. Diagnostic issues Principles of psychiatric assessment in this population are similar to those in general adult and child psychiatry; particular attention is given to the person's level of communication and understanding, developmental history, direct observation and information from informants, as well as the exploration of associated disabilities. The predominant view is that psychiatric disorder can be reliably diagnosed using standard diagnostic classifications in people with mild intellectual disability (Meins, 1995; Hurley, 2006). However, diagnosis is more difficult in those with a more severe level of intellectual disability. Diagnostic criteria are very much language-based, so they are less relevant to people with significant communication difficulties. It is then much more difficult, if not impossible, to assess cardinal features of psychiatric disorder such as low self-esteem, guilt (Hemmings, 2007), delusions or hallucinations. The presence of intellectual disability will alter the way that signs of psychiatric disorder manifest themselves. Psychiatric diagnosis can be difficult because of the frequent assumption that symptoms could be part of the presentation of the intellectual disability because of ‘diagnostic overshadowing’ (Santosh & Baird, 1999).
Recombinant glycoproteins resembling carbohydrate-specific IgE epitopes from plants, venoms and mites (2018)

Defined recombinant HHM-glycoproteins resembling carbohydrate-specific IgE epitopes from plants, venoms and mites were engineered which made it possible to discriminate carbohydrate- from peptide-specific IgE reactivity.
Synchronization of Normal-GVD Kerr Combs (2021)

We demonstrate all-optical synchronization of Kerr combs in the normal group-velocity dispersion regime. Our results reveal the universality of Kerr comb synchronization and extend its scope beyond soliton modelocking.
Supplementary Methods from Distinct Effects of Ligand-Induced PDGFRα and PDGFRβ Signaling in the Human Rhabdomyosarcoma Tumor Cell and Stroma Cell Compartments (2023)

&lt;p&gt;PDF file - 93K, Includes Gene expression profiles, RNA preparation and qRT-PCR analysis, PDGFRβ stimulation assay, and supplementary references&lt;/p&gt;
Tunable Photonic Microwave Filter using Slow Light in Vertical Cavity Surface Emitting Laser (2009)

A tunable photonic microwave filter using slow light in a VCSEL is proposed and experimentally demonstrated for the first time. Tunable microwave notch filter at 20 GHz can be achieved by adjusting the bias current of VCSEL.
Rare CACNA1H and RELN variants interact through mTORC1 pathway in oligogenic autism spectrum disorder (2022)

Oligogenic inheritance of autism spectrum disorder (ASD) has been supported by several studies. However, little is known about how the risk variants interact and converge on causative neurobiological pathways. We identified in an ASD proband deleterious compound heterozygous missense variants in the Reelin (RELN) gene, and a de novo splicing variant in the Cav3.2 calcium channel (CACNA1H) gene. Here, by using iPSC-derived neural progenitor cells (NPCs) and a heterologous expression system, we show that the variant in Cav3.2 leads to increased calcium influx into cells, which overactivates mTORC1 pathway and, consequently, further exacerbates the impairment of Reelin signaling. Also, we show that Cav3.2/mTORC1 overactivation induces proliferation of NPCs and that both mutant Cav3.2 and Reelin cause abnormal migration of these cells. Finally, analysis of the sequencing data from two ASD cohorts-a Brazilian cohort of 861 samples, 291 with ASD; the MSSNG cohort of 11,181 samples, 5,102 with ASD-revealed that the co-occurrence of risk variants in both alleles of Reelin pathway genes and in one allele of calcium channel genes confer significant liability for ASD. Our results support the notion that genes with co-occurring deleterious variants tend to have interconnected pathways underlying oligogenic forms of ASD.
Extreme Adventure Collection : - / Universal Pictures Home Entertainment (2016)

Film dokumenter ini terdiri dari 3 film utama yakni : Tornado Alley, Grand Canyon Adventure River at Risk, dan Hidden Universe. kesemuanya menyajikan berbagai video yang indah dan menakjubkan dari tempat-tempat eksotik di beberapa belahan bumi dan jagat raya yang kita kenal ini