gebhart/patrepeval huggingface dataset:
Sequence and phylogenetic analysis of theSNF4/AMPKgamma subunit gene fromDrosophila melanogaster (1999)

To optimize gene expression under different environmental conditions, many organisms have evolved systems which can quickly up- and down-regulate the activity of other genes. Recently, the SNF1 kinase complex from yeast and the AMP-activated protein kinase complex from mammals have been shown to represent homologous metabolic sensors that are key to regulating energy levels under times of metabolic stress. Using heterologous probing, we have cloned the Drosophila melanogaster homologue of SNF4, the noncatalytic effector subunit from this kinase complex. A sequence corresponding to the partial genomic sequence as well as the full-length cDNA was obtained, and shows that the D. melanogaster SNF4 is encoded in a 1944-bp cDNA representing a protein of 648 amino acids (aa). Southern analysis of Drosophila genomic DNA in concert with a survey of mammalian SNF4 ESTs indicates that in metazoans, SNF4 is a duplicated gene, and possibly even a larger gene family. We propose that one gene copy codes for a short (330 aa) protein, whereas the second locus codes for a longer version (&lt;410 aa) that is extended at the carboxy terminus, as typified by the Drosophila homologue presented here. Phylogenetic analysis of yeast, invertebrate, and multiple mammalian isoforms of SNF4 shows that the gene duplication likely occurred early in the metazoan lineage, as the protein products of the different loci are relatively divergent. When the phylogeny was extended beyond the SNF4 gene family, SNF4 shares sequence similarity with other cystathionine-β-synthase domain-containing proteins, including IMP dehydrogenase and a variety of uncharacterized Methanococcus proteins.Key words: SNF4, AMPK gamma subunit, derepression, gene family, phylogeny.
GW24-e1812 Comparative study on clinical efficacy of intravenous injection with Cedilanid, Propafenone, and Amiodarone to control with instantly ventricular rate of fast supraventricular arrhythmia (2013)

Objectives To compare clinical efficacy of intravenous injection with Cedilanid, Propafenone, and Amiodarone to control with instantly ventricular rate of fast supraventricular arrhythmia. Methods 98 patients with fast supraventricular arrhythmia were chosen from various kinds of heart disease. They were randomly divided into Cedilanid group (32 cases), Propafenone group (31 cases), and Amiodarone group (35 cases). All of cases were excluded contraindications of medication. The dose of drug in three groups was respectively applied with 0.4mg (total less than 0.8mg), 1.0-1.5mg/kg (total less than 210 mg), 100-150 mg (total less than 450mg), which was added in 5%GS 10∼20ml and slowly injected within 10-15min. Continuous ECG and blood pressure were monitored before, during and after the process of medication. It was considered effectiveness when supraventricular arrhythmia turned to sinus rhythm, ventricular rate were below 100bpm or ventricular rate was decreased more than 25%. Results Patients turning to sinus rhythm after treatment in three groups, were respectively 3,6 and 8 cases. The ventricular rate below 100bpm in three groups was respectively 15, 9 and 14 cases. The ventricular rate decreased more than 25% in three groups was respectively 10, 11 and 8 cases. The effective power was respectively 87.5%, 83.9% and 85.7% in three groups. The average ventricular rate decreased about 30.7%, 29.1% and 27.8% after treatment in 3 groups. There were no un-happened intolerable side effects caused by medication. Conclusions Intravenous injection with Cedilanid, Propafenone, and Amiodarone to control with instantly ventricular rate of fast supraventricular arrhythmia are reliable efficacy, and have no significant difference among them. It is safe, effective and rapid to control fast ventricular arrhythmias with them and can be used as first-line drugs.
ChemInform Abstract: Stereoselective Synthesis of (2S,3S)‐Norstatine Derivatives by Addition of Lithiated Methoxyallene to Amino Aldehydes and Subsequent Ozonolysis. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
High resolution ultrasonic backscatter coefficient estimation based on autoregressive spectral estimation using Burg's algorithm (1994)

An autoregressive (AR) method for spectral estimation was applied toward the task of estimating ultrasonic backscatter coefficients from small volumes of tissue. High spatial resolution is desirable for generating images of backscatter coefficient. Data was acquired from a homogeneous tissue-mimicking phantom and from a normal human liver in vivo. The AR method was much more resistant to gating artifacts than the traditional DFT (discrete Fourier transform) approach. The DFT method consistently underestimated backscatter coefficients at small gate lengths. Therefore backscatter coefficient image formation will be quantitatively more meaningful if based on AR spectral estimation rather than the DFT. The autoregressive method offers promise for enhanced spatial resolution and accuracy in ultrasonic tissue characterization and nondestructive evaluation of materials.
Deep-Learned Air-Coupled Ultrasonic Sonar Image Enhancement and Object Localization (2022)

Air-coupled ultrasonic phased arrays are a complement to existing lidar-, camera- and radar-based sensors for object detection and spatial imaging. These in-air sonar systems typically use conventional beamforming (CBF) for high-frame rate image formation. Consequently, in real-world multi-target environments, the unique identification of reflectors is a challenging task due to the array-specific point spread function (PSF). Therefore, we present a neural auto-encoder network based on Xception for removing the PSF characteristics from CBF images and estimating the number of reflectors. Based on this information, the reflector coordinates are extracted by Gaussian mixture model clustering. We train and test the architecture on simulated and randomized multi-target CBF images. The performance is evaluated in terms of the localization precision, reflector count error and the angular resolution obtained. The preliminary results show a low mean error for the localization (-0.61°, -3 mm) and an accuracy of 83% for the reflector count estimation. The angular resolution of the given array can be improved from 14° to 2°. Overall, we highlight the potential of state-of-the-art auto-encoder networks, typically used for optical images, for CBF image enhancement and the combination with clustering for target localization.
Safety and Efficiency of Diagnostic Strategies for Ruling Out Pulmonary Embolism in Clinically Relevant Patient Subgroups (2021)

Dutch Research Council. (PROSPERO: CRD42018089366).
AMoCo, a software package for prospective motion correction (2017)

Long scan time makes MRI prone to subject motion which can result in image artifacts. Here we introduce a library for advanced motion correction (AMoCo) for Siemens platforms which can be embedded in any sequence and enables connecting to any tracking device. The library is programmed in a modular way that allows user to customize the correction procedure. The library is integrated with EPI, GRE, and FLASH sequences and tested with various tracking devices.
We know where you are! (2016)

Mobile network technologies require some degree of tracking of user location, specifically user equipment tracking, as part of their fundamental mechanism of working. Without this basic function, features such as hand-over between cells would not work. Since mobile devices are typically associated with a single person, this provides a potential mechanism for user location surveillance. Network operators are bound by strict privacy legislation. However, spying by certain agencies, hackers and even advertisers without the users' or operators' knowledge has become a serious issue. In this article, we introduce and explain all known recent attacks on mobile networks that compromised user privacy. We focus on attacks using the Signalling System 7 (SS7) protocol as the interconnection interface between operators mainly in GSM networks. In addition, we outline a novel evolution of location tracking for LTE networks. One reason these attacks are not widely published or known by the general public is due to the complex and arcane nature of the networks and their protocols. Mobile network interfaces are `hidden' from users, and therefore the general public's interest in such attacks is much lower compared to other phone vulnerabilities. The purpose of the paper is to raise awareness about the current location tracking problem in cellular networks, the existing countermeasures and to encourage further research in the area for 5G networks.
Comblike Polymethacrylates with Poly(ethylene glycol) Side Chains via Nitroxide-Mediated Controlled Free-Radical Polymerization (2008)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTComblike Polymethacrylates with Poly(ethylene glycol) Side Chains via Nitroxide-Mediated Controlled Free-Radical PolymerizationJulien Nicolas*†, Patrick Couvreur†, and Bernadette Charleux‡View Author Information Laboratoire de Physico-Chimie, Pharmacotechnie et Biopharmacie, UMR CNRS 8612, Faculté de Pharmacie, Univ. Paris-Sud, 5 rue Jean-Baptiste Clément, FR 92296 Châtenay-Malabry, France, and Laboratoire de Chimie des Polymères, UMR CNRS 7610, UPMC Paris 6, 4 place Jussieu, FR 75252 Paris cedex 05, France* Corresponding author: Tel +33 1 46 83 58 53 ; fax +33 1 46 61 93 34; e-mail [email protected]†Univ. Paris-Sud.‡UPMC Paris 6.Cite this: Macromolecules 2008, 41, 11, 3758–3761Publication Date (Web):May 8, 2008Publication History Received19 March 2008Revised14 April 2008Published online8 May 2008Published inissue 1 June 2008https://pubs.acs.org/doi/10.1021/ma800609bhttps://doi.org/10.1021/ma800609brapid-communicationACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views904Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Ethanol,Monomers,Organic compounds,Polymerization,Styrenes Get e-Alerts
84‐4: New Barrier Fabrication Method based on an Infiltration Technology for Flexible OLED Displays (2020)

In this work, new barrier fabrication method is proposed to make the barrier layer for blocking the permeation of an oxygen and water and for improving the flexibility. To do this, infiltration technology is implemented to fabricate an in/organic hybrid thin barrier layer for flexible OLED displays. In/organic hybrid layer shows the good WVTR property (~10‐5 g/m2·day), the flexibility after a folding test and the good reliability for the life time test. From the results, this method can be applied to flexible OLED displays for improving the performance.
Lack of active SARS-CoV-2 virus in a subset of PCR-positive COVID-19 congregate care patients (2021)

Highly sensitive nucleic acid amplification tests (NAATs) designed to detect SARS-CoV-2 RNA are the standard of care for the diagnosis of COVID-19. However, the accuracy of these methods for the quantitation of active virus rather than non-infectious RNA fragments that can persist for extended periods of time has been unclear. This issue is particularly relevant for congregate care patients who are unable to return to their home residence until fully negative by NAATs. We tested paired samples from individual patients for the presence of virus at both early and later stages of disease. Culture of nasopharyngeal swab samples for 10 days in Vero E6 cells revealed active virus in only 4 out of 14 (28.6%) patients. The ability to isolate viral plaque-forming units (PFU) correlated with viral RNA loads of >6.79 log genomic copies/ml and only occurred in samples collected from patients early after symptom onset and before development of antibody. Culture in Vero E6 cells lacking the STAT1-dependent interferon signaling pathway increased the numbers of viral PFU detected but did not affect the incidence of positive cultures. We conclude that culturable virus is correlated with SARS-CoV-2 NAATs detection only during early symptom onset and with high viral titers/low antibody titers in non-immunosuppressed patients.
Liouville quantum gravity spheres as matings of finite-diameter trees (2019)

Nous montrons que la sphère de gravité quantique de Liouville d’aire unité peut être construite de deux façons équivalentes. La première, introduite par les auteurs et Duplantier dans (Liouville quantum gravity as a mating of trees (2014) Preprint), utilise la mesure d’excursion d’un processus de Bessel pour définir une variante du champ libre gaussien sur le cylindre. La seconde utilise une boucle d’un mouvement brownien corrélé et un « accouplement d’arbres » pour produire une sphère de gravité quantique de Liouville décorée par un chemin remplissant l’espace. Dans le cas particulier où $\gamma=\sqrt{8/3}$, nous présentons une troisième construction équivalente, utilisant la mesure d’excursion d’un processus de Lévy stable d’exposant $3/2$ (sans sauts négatifs) pour produire une paire d’arbres de disques quantiques que l’on peut accoupler pour obtenir une sphère décorée par un $\mathrm{SLE}_{6}$. Cette construction intervient dans un programme ayant pour but de montrer que la sphère de gravité quantique de Liouville pour $\gamma=\sqrt{8/3}$ est équivalente à la carte brownienne.
Integration of Static and Dynamic Data for Enhanced Reservoir Characterization, Geological Modeling and Well Performance Studies (2013)

Abstract A new methodology is presented for reservoir characterization, geological modeling, and well performance prediction by integrating a complete suite of petrophysical and pressure transient test data to build a detailed geological reservoir model with anisotropy. Data used includes cores, openhole logs, wireline formation tester (WFT) pretests, and vertical interference tests (VIT), production logs, and downhole pressure buildup and injection falloff tests. Core data is first integrated with openhole logs and WFT pretests to build a detailed geological model. Vertical and horizontal permeabilities derived from the VITs were then integrated to have a geological model with anisotropy. With the model, a single-well numerical pressure transient analysis was performed by simultaneously history matching the packer and the probe pressures as well as pressure derivatives to identify the presence of tight reservoir streaks and quantify reservoir layer permeability ranges. The model is further refined and validated by comparing with dynamic data derived from production logs and downhole pressure build-up and injection fall off tests. This validated reservoir model was used in single well reservoir simulation studies to predict well performance and inferring insitu reservoir scale reservoir condition petrophysical properties such as relative permeability and capillary pressure.
Galaxy content of selected southern groups - Elliptical galaxies at low density (1983)

The dependence of disk galaxy morphology on local surface density which was demonstrated by Dressler (1980) holds for the presently studied large sample of galaxies, and a systematic misclassification of certain weak-dished galaxies as elliptical galaxies is noted on plate material similar to the Southern Sky Survey. Employing only the classifications made from sky-limited, large scale plates, the dependence of elliptical fraction on local density is found to be very weak. The groups sampled all include a bright, elliptical-like galaxy, and the density of elliptical galaxies in the field is lower than in these groups. A combination of these results with those of Wirth and Gallagher (1980) concerning the dwarf population in groups and clusters indicates the operation of a gas removal mechanism in the neighborhood of giant elliptical galaxies.
Apoptosis of human leukemia cells induced by Artepillin C, an active ingredient of Brazilian propolis. (2001)

Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) is an active ingredient of Brazilian propolis that possesses anti-tumor activity. When Artepillin C was applied to human leukemia cell lines of different phenotypes, namely, lymphocytic leukemia (7 cell lines of T-cell, 5 cell lines of B-cell), myeloid and monocytic leukemia and non-lymphoid non-myeloid leukemia cell lines in vitro, Artepillin C exhibited potent cytocidal effects and induced marked levels of apoptosis in all the cell lines. The most potent effects were observed in the T-cell lines. Apoptotic bodies and DNA fragmentation were induced in the cell lines after exposure to Artepillin C. DNA synthesis in the leukemia cells was clearly inhibited and disintegration of the cells was confirmed microscopically. Apoptosis of the leukemia cells may be partially associated with enhanced Fas antigen expression and loss of mitochondrial membrane potential. In contrast, although Artepillin C inhibited the growth of pokeweed mitogen (PWM)-stimulated normal blood lymphocytes, it was not cytocidal to normal unstimulated lymphocytes. These results suggested that Artepillin C, an active ingredient of Brazilian propolis, has anti-leukemic effects with limited inhibitory effects on normal lymphocytes.
The biosynthesis of Lewis X in Helicobacter pylori (1995)

The biosynthesis of the Lewis X determinant (Gal beta 1-4 [Fuc alpha 1-3]GlcNAc beta-) in three strains of Helicobacter pylori has been investigated. Strains UA 861, UA 802 and UA 1182 contain alpha 1,3 fucosyltransferase and beta 1,4 galactosyltransferase activities that synthesize the Lewis X structure by the transfer of monosaccharides from GDP-fucose and UDP-galactose donors, respectively. The enzyme reaction products that formed were characterized by capillary zone electrophoresis and by 1H-NMR spectroscopy. The biosynthetic pathway is therefore identical to that found in humans. In the three strains, the fucosyltransferase and galactosyltransferase activities differed in various cellular fractions. Km values for their donor and acceptor substrates also differed.
Invertible Orientation Scores of 3D Images (2015)

The enhancement and detection of elongated structures in noisy image data is relevant for many biomedical applications. To handle complex crossing structures in 2D images, 2D orientation scores were introduced, which already showed their use in a variety of applications. Here we extend this work to 3D orientation scores. First, we construct the orientation score from a given dataset, which is achieved by an invertible coherent state type of transform. For this transformation we introduce 3D versions of the 2D cake-wavelets, which are complex wavelets that can simultaneously detect oriented structures and oriented edges. For efficient implementation of the different steps in the wavelet creation we use a spherical harmonic transform. Finally, we show some first results of practical applications of 3D orientation scores.
Two Degree-of-Freedom Controllers for Hard Disk Drives with Novel Reference Trajectory Design (2000)

This paper considers the determination of reference trajectories for use with a two-degree-of-freedom (2-DOF) controller for the head positioning of Hard Disk Drives (HDDs). The reference HDD model used for the design includes the back e.m.f. (electromotive force) of the voice coil motor. In the second stage, the idea of SMART (Structure vibration Minimized AcceleRation Trajectory) is utilized to adjust the errors at the end of the trajectories. 2-DOF control with the proposed reference trajectory is compared to conventional mode switching control, and its effectiveness is verified. To minimize performance degradation due to disturbances and uncertainties, the use of Adaptive Robust Control (ARC) is suggested.
Location-based Services via IEEE 802.11b Hot Spots. (2004)

Providers of location-based services face the problem to select and dimension the infrastructure to transmit the content to the users of their service. Thereby, location-based services for mobile users pose special issues, because of the locally limited scope of the content. We define a scenario consisting of service requirements in terms of spatial throughput and a simple mobility model. This scenario is then investigated regarding two possible infrastructures: Connection via a cellular network or alternatively via isolated Wireless LAN Hot Spots. We estimate whether the service can be delivered via a cellular network or if Hot Spots should be used, how many of these are required. We confirm our findings by simulations.
Effects of particle size and porosity on in vivo remodeling of settable allograft bone/polymer composites (2015)

Established clinical approaches to treat bone voids include the implantation of autograft or allograft bone, ceramics, and other bone void fillers (BVFs). Composites prepared from lysine-derived polyurethanes and allograft bone can be injected as a reactive liquid and set to yield BVFs with mechanical strength comparable to trabecular bone. In this study, we investigated the effects of porosity, allograft particle size, and matrix mineralization on remodeling of injectable and settable allograft/polymer composites in a rabbit femoral condyle plug defect model. Both low viscosity and high viscosity grafts incorporating small (<105 μm) particles only partially healed at 12 weeks, and the addition of 10% demineralized bone matrix did not enhance healing. In contrast, composite grafts with large (105-500 μm) allograft particles healed at 12 weeks postimplantation, as evidenced by radial μCT and histomorphometric analysis. This study highlights particle size and surface connectivity as influential parameters regulating the remodeling of composite bone scaffolds.