gebhart/patrepeval huggingface dataset:
Nouvelles familles de pseudopeptides incluant une unite hydrazinoglycine n -substituee. Synthese, mise en evidence d'une structure secondaire dans le cas des oligomeres (foldameres). Perspectives d'evaluation dans le domaine peptidomimetique (2000)

L'objectif de ce travail est la synthese et l'etude de nouveaux pseudopeptides hybrides et oligomeres pseudopeptidiques incorporant une ou plusieurs unite(s) hydrazinoglycine(s) n -substituee(s). Dans un premier temps nous rappelons les travaux de la litterature se rapportant a l'etude des oligomeres pseudopeptidiques les plus proches de nos composes. La synthese des hydrazinoazapeptoides selon une methode sous-monomerique est ensuite decrite. Basee sur la chimie des hydrazines, cette methode de synthese permet de preparer ces pseudopeptides en introduisant aisement des chaines laterales de nature variee au niveau des residus hydrazinoglycines n -substituees qui sont associes a un motif azaaminoester. Nous presentons ensuite la synthese des monomeres hydrazinoglycines esters n -substitues n -proteges et de leurs derives deproteges a l'extremite n- ou c-terminale ou bien encore des alcools, et aldehydes correspondants. Ces monomeres constituent les briques necessaires a la synthese des oligomeres hydrazinopeptoidiques et des n-hydrazinopeptides que nous preparons, en utilisant les techniques usuelles de la synthese peptidique classique (protection / deprotection et utilisation d'agents de couplage) en solution. Nous discutons egalement de la problematique et de l'analyse des premiers resultats concernant l'etude de la structuration, a l'etat solide et en solution, induite par l'introduction de ces motifs hydrazinoglycines n -substituees dans des peptides, des pseudopeptides ou bien sous forme d'oligomeres. L'utilisation de ces monomeres hydrazinoglycines n -substituees pour la synthese de n-hydrazinopeptides sur support solide a l'aide d'un automate est egalement presentee. Ces composes seront evalues comme agents d'immunomodulation.
RCL1 copy number variants are associated with a range of neuropsychiatric phenotypes (2021)

Mendelian and early-onset severe psychiatric phenotypes often involve genetic variants having a large effect, offering opportunities for genetic discoveries and early therapeutic interventions. Here, the index case is an 18-year-old boy, who at 14 years of age had a decline in cognitive functioning over the course of a year and subsequently presented with catatonia, auditory and visual hallucinations, paranoia, aggression, mood dysregulation, and disorganized thoughts. Exome sequencing revealed a stop-gain mutation in RCL1 (NM_005772.4:c.370 C > T, p.Gln124Ter), encoding an RNA 3'-terminal phosphate cyclase-like protein that is highly conserved across eukaryotic species. Subsequent investigations across two academic medical centers identified eleven additional cases of RCL1 copy number variations (CNVs) with varying neurodevelopmental or psychiatric phenotypes. These findings suggest that dosage variation of RCL1 contributes to a range of neurological and clinical phenotypes.
Post-silicon timing characterization by compressed sensing (2008)

We address post-silicon characterization of the unique gate delays and their timing distributions on each manufactured IC. Our proposed approach is based upon the new theory of compressed sensing. The first step in performing timing measurements is to find the sensitizable paths by traditional testing methods. Next, we show that the timing variations are sparse in the wavelet domain. The sparsity is exploited for estimation of the gate delays using the compressed sensing theory. This estimation method requires significantly less number of timing measurements compared to the case where the dependence between the gate delays is not directly integrated within the estimation framework. We discuss a number of applications for the new post-silicon timing characterization method. Experimental results on benchmark circuits show that using compressed sensing theory can characterize the post-silicon variations with a mean accurately of 95% in the pertinent sparse basis.
Sustainability: Waste minimization, green chemistry and inherently safer processing (2000)

Abstract Webster's New Collegiate Dictionary defines sustainable as “maintain, or cause to continue, in existence or a certain state.” The word “sustainable” is now used to define a world that is able to “maintain in existence” all life that now exists. To attain that goal, human activities will need to change. Waste Minimization, Green Chemistry, and Inherently Safer Processes all seek to manufacture chemicals in an environmentally sustainable way by reducing waste generation, minimizing the impact of chemicals and chemical processes on the environment and the public, and minimizing any hazards to the workers. In this paper, we discuss the synergies among these concepts. The three disciplines must better coordinate their efforts to capitalize on the total teachings, develop and retrofit manufacturing processes using the best technologies, and ensure the highest return projects. In the end, the ultimate chemical process will produce a non‐toxic, recyclable or easily biodegradable product that meets society's needs, produces no waste, is inherently safer, and uses renewable feed materials.
A Comparison of Phosphaferrocene and Phospharuthenocene Ligands in Rh+‐Catalysed Enamide Hydrogenation Reactions: Superior Performance of the Phospharuthenocene (2007)

Enantiopure Cp*-substituted 3,4-dimethyl-5-phenylphosphametallocene-2-methanols (M=Fe, Ru) have been prepared from the corresponding 2-carboxy-(-)-menthylphospholide anion and elaborated into 2-CH(2)PPh(2) phosphametallocenes (13: M=Fe; 14: M=Ru) and 2-CH(2)PtBuR substituted phospharuthenocenes (R=tBu, Me). The crystal structures of complexes [Rh(1,5-cod)(eta(2)-L)](+)BF(4)(-) (L=13, 14) reveal significantly different aryl group configurations. Comparative studies of the hydrogenation of para-substituted N-acetylcinnamate esters with these pre-catalysts show a superior performance for the phospharuthenocene derivative in terms of both rate and enantioselectivity.
Radiation-induced cationic polymerization of isobutylene-isopene systems: advantages and disadvantages compared to catalytic initiation (1976)

The cationic copolymerization of isobutylene (1) with isoprene (2) has been induced by ..gamma..-irradiation of dry comonomer systems in bulk. Although the polymer conversion per unit dose is reduced about a thousand-fold by the addition of 3 mole % isoprene to isobutylene, the molecular weight of the copolymer is comparable to that of the homopolymer of isobutylene prepared at the same polymerization temperature. The copolymer composition corresponds closely to that of the monomer feed up to 7.1 mole % isoprene. The results are consistently accounted for by postulating that the slow step in the kinetic chain is the cross-propagation reaction described by the rate constant k/sub p21/ with an estimated value of 3 x 10/sup 8/ M/sup -1/ sec/sup -1/ at 0/sup 0/C, this constant being much less than k/sub p12/ similarly ordered k/sub p11/ = 1.5 x 10/sup 8/ M/sup -1/ sec/sup -1/. The viscosity-average molecular weights of the radiation-induced copolymers are about a factor of ten higher than those produced by BF/sub 3/, AlEtCl/sub 2/, and AlCl/sub 3/ at the same polymerization temperature. This effect is similar to that observed previously for the homopolymers of isobutylene and is attributed to the free-ion character of the radiation-induced polymerization. Despitemore » this advantage enjoyed by the ..gamma..-irradiation method, it is subject to various practical limitations, of which the foremost is the inability to tolerate suitable solvents such as methyl chloride without sacrificing a large reduction in polymerization rate.« less
Current status and future prospects of activated recombinant coagulation factor VIIa, NovoSeven®, in the treatment of haemophilia and rare bleeding disorders (2023)

rFVIIa, a human recombinant activated coagulation factor VII, has been used worldwide for more than two decades for the treatment of bleeding episodes and prevention of bleeding in patients undergoing surgery/invasive procedures with congenital haemophilia A or B with inhibitors (CHwI A or B), acquired haemophilia (AH), congenital factor VII deficiency and Glanzmann thrombasthenia (GT), refractory to platelet transfusion. The approved dosage, administration and indication of rFVIIa in the US, Europe and Japan differ, depending on the needs of the patient population and regulatory practices. This review presents an overview of the current status and future prospects, including that from a Japanese perspective, of using rFVIIa in the treatment of approved indications. The efficacy and safety of rFVIIa in the approved indications has been demonstrated in several randomised and observational studies and data from registries. The overall incidence of thrombosis across all approved indications in a retrospective safety assessment of clinical trials and registries, prelicensure studies and postmarketing surveillance studies of rFVIIa use was 0.17%. Specifically, the risk of thrombotic events was 0.11% for CHwI, 1.77% for AH, 0.82% for congenital factor VII deficiency and 0.19% for GT. Emerging non-factor therapies such as emicizumab have changed the treatment landscape of haemophilia A, including preventing bleeding in patients with CHwI. However, rFVIIa will continue to play a significant role in the treatment of such patients, particularly during breakthrough bleeding or surgical procedures.
Searches for heavy diboson resonances in pp collisions at s = 13 $$ \sqrt{s}=13 $$ TeV with the ATLAS detector (2016)

Searches for new heavy resonances decaying to W W , W Z, and ZZ bosons are presented, using a data sample corresponding to 3.2 fb -1 of pp collisions at s = 13 TeV collected with the ATLAS detector at the CERN Large Hadron Collider. Analyses selecting qq, qq, qq and qqqq final states are combined, searching for a narrow-width resonance with mass between 500 and 3000 GeV. The discriminating variable is either an invariant mass or a transverse mass. No significant deviations from the Standard Model predictions are observed. Three benchmark models are tested: a model predicting the existence of a new heavy scalar singlet, a simplified model predicting a heavy vector-boson triplet, and a bulk Randall-Sundrum model with a heavy spin-2 graviton. Cross-section limits are set at the 95% confidence level and are compared to theoretical cross-section predictions for a variety of models. The data exclude a scalar singlet with mass below 2650 GeV, a heavy vector-boson triplet with mass below 2600 GeV, and a graviton with mass below 1100 GeV. These results significantly extend the previous limits set using pp collisions at s = 8 TeV.
Nitrogen Recovery from Wastewater: Possibilities, Competition with Other Resources, and Adaptation Pathways (2018)

Due to increased food production, the demand for nitrogen and phosphorus as fertilizers grows. Nitrogen-based fertilizers are produced with the Haber–Bosch process through the industrial fixation of N2 into ammonia. Through wastewater treatment, the nitrogen is finally released back to the atmosphere as N2 gas. This nitrogen cycle is characterized by drawbacks. The energy requirement is high, and in the wastewater treatment, nitrogen is mainly converted to N2 gas and lost to the atmosphere. In this study, technologies for nitrogen recovery from wastewater were selected based on four criteria: sustainability (energy use and N2O emissions), the potential to recover nitrogen in an applicable form, the maturity of the technology, and the nitrogen concentration that can be handled by the technology. As in wastewater treatment, the focus is also on the recovery of other resources; the interactions of nitrogen recovery with biogas production, phosphorus recovery, and cellulose recovery were examined. The mutual interference of the several nitrogen recovery technologies was studied using adaptive policy making. The most promising mature technologies that can be incorporated into existing wastewater treatment plants include struvite precipitation, the treatment of digester reject water by air stripping, vacuum membrane filtration, hydrophobic membrane filtration, and treatment of air from thermal sludge drying, resulting respectively in 1.1%, 24%, 75%, 75%, and 2.1% nitrogen recovery for the specific case wastewater treatment plant Amsterdam-West. The effects on sustainability were limited. Higher nitrogen recovery (60%) could be realized by separate urine collection, but this requires a completely new infrastructure for wastewater collection and treatment. It was concluded that different technologies in parallel are required to reach sustainable solutions. Nitrogen recovery does not interfere with the recovery of the other resources. An adaptation pathways map is a good tool to take into account new developments, uncertainties, and different ambitions when choosing technologies for nitrogen recovery.
Synthesis of Cyclopentanyl Carbocyclic 5-Fluorocytosine ((−)-5-Fluorocarbodine) Using a Facially Selective Hydrogenation Approach (2012)

An efficient synthetic route to biologically relevant (-)-5-fluorocarbodine 6 was developed. Direct coupling of N(6)-protected 5-fluorouracil 15 with cyclopentenyl intermediate 13, followed by formation of a macrocycle between the base and the carbocyclic sugar moiety, via ring-closing metathesis, allowed for a facial selective hydrogenation of the sugar double bond to give, exclusively, the desired 4'-β stereoisomer.
Iron Ore Reduction by Hydrogen Using a Laboratory Scale Fluidized Bed Reactor: Kinetic Investigation—Experimental Setup and Method for Determination (2019)

Abstract The reduction kinetics of hematite iron ore fines to metallic iron by hydrogen using a laboratory fluidized bed reactor were investigated in a temperature range between 873 K and 1073 K, by measuring the weight change of the sample portion during reduction. The fluidization conditions were checked regarding plausibility within the Grace diagram and the measured pressure drop across the material during experiments. The apparent activation energy of the reduction was determined against the degree of reduction and varied along an estimated two-peak curve between 11 and 55 kJ mol −1 . Conventional kinetic analysis for the reduction of FeO to metallic iron, using typical models to describe gas–solid reactions, does not show results with high accuracy. Multistep kinetic analysis, using the Johnson–Mehl–Avrami model, shows that the initial stage of reduction from Fe 2 O 3 to Fe 3 O 4 , and partly to FeO, is controlled by diffusion and chemical reaction, depending on the temperature. Further reduction can be described by a combination of nucleation and chemical reaction, whereby the influence of nucleation increases with an increasing reduction temperature. The results of the kinetical analysis were linked to the shape of the curve from apparent activation energy against the degree of reduction.
Photomagnetism in Cyano-Bridged Bimetal Assemblies (2012)

The study of photoinduced phase-transition materials has implications for the fields of inorganic chemistry, solid-state chemistry, and materials science. Cyano-bridged bimetal assemblies are promising photomagnetic materials. Because cyano-bridged bimetal assemblies possess various absorption bands in the visible light region, their electronic and spin states can be controlled by visible light irradiation. Moreover, the selection of magnetic metal ions and organic ligands provide a way of controlling spin-spin interactions through a cyano bridge. In this Account, we describe cyano-bridged bimetal assemblies developed in our laboratory. Cu(II)(2)[Mo(IV)(CN)(8)]·8H(2)O (CuMo), Rb(I)Mn(II)[Fe(III)(CN)(6)] (RbMnFe), and Co(II)(3)[W(V)(CN)(8)](2)·(pyrimidine)(4)·6H(2)O (CoW) induce photomagnetism via photoinduced metal-to-metal charge transfers (MM'CT), while Fe(II)(2)[Nb(IV)(CN)(8)]·(4-pyridinealdoxime)(8)·2H(2)O (FeNb) exhibits a photoinduced magnetization via a photoinduced spin crossover. Irradiation with 473 nm light causes the CuMo system to exhibit a spontaneous magnetization with a Curie temperature (T(C)) of 25 K, but irradiation with 532, 785, and 840 nm light reduces the magnetization. In this reversible photomagnetic process, excitation of the MM'CT from Mo(IV) to Cu(II) produces a ferromagnetic mixed-valence isomer of Cu(I)Cu(II)[Mo(V)(CN)(8)]·8H(2)O (CuMo'). CuMo' returns to CuMo upon irradiation in the reverse-M'MCT band. RbMnFe shows a charge transfer (CT)-induced phase transition from the Mn(II)-Fe(III) phase to the Mn(III)-Fe(II) phase. Irradiation with 532 nm light converts the Mn(III)-Fe(II) phase into the Mn(II)-Fe(III) phase, and we observe photodemagnetization. In contrast, irradiation of the Mn(II)-Fe(III) phase with 410 nm light causes the reverse phase transition. A CT-induced Jahn-Teller distortion is responsible for this visible light-induced reversible photomagnetic effect. In the CoW system, a CT-induced spin transition causes the thermal phase transition from the Co(II)-W(V) phase to the Co(III)-W(IV) phase. Irradiation of the Co(III)-W(IV) phase with 840 nm light causes ferromagnetism with a T(C) of 40 K and magnetic coercive field (H(c)) of 12,000 Oe, but excitation of the back M'MCT (Co(II) → W(V)) with 532 nm light leads to the reverse phase transition. These examples of the photomagnetic effect have occurred by exciting MM'CT bands. In the fields of inorganic chemistry and materials science, researchers have studied extensively the photoinduced phase transitions between low-spin (LS) and high-spin (HS) transition metal ions. Recently, we have observed the first example of photoinduced spin crossover ferromagnetism with a FeNb system (T(C) = 20 K and H(c) = 240 Oe), in which a strong superexchange interaction between photoproduced Fe(II)(HS) and neighboring paramagnetic Nb(IV) operates through a CN bridge. The optical switching magnets described in this Account may lead to novel optical recording technologies such as optomagnetic memories and optical computers.
Human Enhancer of Invasion-Cluster, a Coiled-Coil Protein Required for Passage through Mitosis (2004)

In a cross-species overexpression approach, we used the pseudohyphal transition of Saccharomyces cerevisiae as a model screening system to identify human genes that regulate cell morphology and the cell cycle. Human enhancer of invasion-cluster (HEI-C), encoding a novel evolutionarily conserved coiled-coil protein, was isolated in a screen for human genes that induce agar invasion in S. cerevisiae. In human cells, HEI-C is primarily localized to the spindle during mitosis. Depletion of HEI-C in vivo with short interfering RNAs results in severe mitotic defects. Analysis by immunofluorescence, flow cytometry analysis, and videomicroscopy indicates that HEI-C-depleted cells form metaphase plates with normal timing after G(2)/M transition, although in many cases cells have disorganized mitotic spindles. Subsequently, severe defects occur at the metaphase-anaphase transition, characterized by a significant delay at this stage or, more commonly, cellular disintegration accompanied by the display of classic biochemical markers of apoptosis. These mitotic defects occur in spite of the fact that HEI-C-depleted cells retain functional cell cycle checkpoints, as these cells arrest normally following nocodazole or hydroxyurea treatment. These results place HEI-C as a novel regulator of spindle function and integrity during the metaphase-anaphase transition.
1-ADM-CNN: A Lightweight In-field Compression Method for Seismic Data (2022)

Large-scale seismic acquisition, versatility, flexibility, automation, and scalability are the objectives of future oil and gas exploration technology. An example of emerging technology for seismic monitoring is distributed acoustic sensing (DAS). The significant amount of data produced by DAS is a challenge that necessitates the development of new technologies for its efficient handling and processing. A typical seismic survey, on the one hand, can generate hundreds of terabytes of raw seismic data per day. The demand for wireless seismic data transmission, on the other hand, remains enormous. The massive amount of data transmission from geophones to the on-site data collection center and its storage poses significant challenges. A lightweight compression procedure is required in order to reduce the data traffic and the storage size at the data center without putting an extra burden on a geophone. In this brief, an efficient implementation of a 1D convolutional neural network (CNN) together with 1-bit adaptive delta modulation is presented for in-field seismic data compression. It is worth mentioning here that the training of CNN is done offline on synthetic data set and hence, the proposed approach has potential for real-time implementation. Furthermore, no assumption on the underlying statistics of noise or the seismic signal is imposed and consequently, the proposed method is suitable for a wide range of seismic data. Furthermore, the proposed method works in the time-domain, unlike existing transform-domain methods, making it suitable for quick diagnosis of bad traces at the data center. Simulation results with real data set reveal that the proposed approach achieves a signal-to-noise ratio (SNR) of approximately 30 dB with a compression gain of 35: 1. Finally, significant superiority in terms of compression gain and reconstruction quality is demonstrated when compared to the existing methods.
Enhanced Cell–Chip Coupling by Rapid Femtosecond Laser Patterning of Soft PEDOT:PSS Biointerfaces (2017)

Interfacing soft materials with biological systems holds considerable promise for both biosensors and recording live cells. However, the interface between cells and organic substrates is not well studied, despite its crucial role in the effectiveness of the device. Furthermore, well-known cell adhesion enhancers, such as microgrooves, have not been implemented on these surfaces. Here, we present a nanoscale characterization of the cell-substrate interface for 3D laser-patterned organic electrodes by combining electrochemical impedance spectroscopy (EIS) and scanning electron microscopy/focused ion beam (SEM/FIB). We demonstrate that introducing 3D micropatterned grooves on organic surfaces enhances the cell adhesion of electrogenic cells.
Copper(II) Tetrafluoroborate‐Catalyzed Ring‐Opening of Epoxides by Amines. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Supplementary Table S2 from ER-851, a Novel Selective Inhibitor of AXL, Overcomes Resistance to Antimitotic Drugs (2023)

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Gender Disparities in Quality of Life and Psychological Disturbance in Patients With Implantable Cardioverter-Defibrillators (2013)

Women reported poorer QOL on 2 subscales: role physical functioning and bodily pain. There was a significant relationship between gender and depression, worry about ICD, and PTSD, but not for anxiety. Female patients need more psychological interventions following ICD implantation.
Alkyloxy-substituted CTTV derivatives that exhibit columnar mesophases (1991)

The homologous series of 2,3,6,7,10,11,14,15-octaalkyloxytetrabenzo[a,d,g,j]cyclododecatetraenes (CTTV-n) containing n= 4–15 methylenic units in the alkyloxy substituents has been prepared both by alkylation of octhydroxytetrabenzocyclododecatetraenes (CTTV-OH), and by cyclotetramerization of the corresponding 3,4-(dialkyloxy)benzyl alcohols using excess CF3CO2H. CTTV-4 is crystalline. All other compounds display an enantiotropic columnar mesophase in addition to melting and crystallization transitions. The phase-transition temperatures of the CTTV-n compounds prepared by cyclotetramerization are lower than those synthesized by etherification of CTTV-OH. Melting and isotropization temperatures decrease in a continuous manner as n increases, without any odd–even alternation.