gebhart/patrepeval huggingface dataset:
Out of control: accelerated aging in uremia (2012)

Next to a high morbidity, patients with end-stage renal failure (ESRD) suffer from a complex spectrum of clinical manifestations. Both the phenotype of patients with ESRD as well as the pathophysiology of uremia show interesting parallels with the general aging process. Phenotypically, patients with ESRD have an increased susceptibility for both cardiovascular as well as infectious disease and show a reduction in functional capacity as well as muscular mass (sarcopenia), translating into a high prevalence of frailty also in younger patients. Pathophysiologically, the immune dysfunction, telomere attrition and the presence of low-grade inflammation in uremic patients also show parallels with the aging process. System models of aging, such as the homeodynamic model and reliability theory of Gavrilov may also have relevance for ESRD. The reduction in the redundancy of compensatory mechanisms and the multisystem impairment in ESRD explain the rapid loss of homeodynamic/homeostatic balance and the increased susceptibility to external stressors in these patients. System theories may also explain the relative lack of success of interventions focusing on single aspects of renal disease. The concept of accelerated aging, which also shares similarities with other organ diseases, may be of relevance both for a better understanding of the uremic process, as well as for the design of multidimensional interventions in ESRD patients, including an important role for early rehabilitation. Research into processes akin to both aging and uremia may result in novel therapeutic approaches.
ChemInform Abstract: The Asymmetric Synthesis of β‐Lactam Antibiotics. Part 1. Application of Chiral Oxazolidones in the Staudinger Reaction. The Asymmetric Synthesis of β‐Lactam Antibiotics. Part 2. The First Enantioselective Synthesis of the Carbacephalosporin Nucleus. (1985)

Abstract Die geschützte Aminosäure (I) ergibt nach Reduktion das definierte Oxazolidon (II), aus dem das Säurechlorid (IIIc) hergestellt wird, das mit Iminen (IV) zu den Azetidinonen (V) neben geringen Anteilen an den epi‐Formen (VI) führt.
Experimental Realization of Dicke States of up to Six Qubits for Multiparty Quantum Networking (2009)

We report the first experimental generation and characterization of a six-photon Dicke state. The produced state shows a fidelity of F=0.56+/-0.02 with respect to an ideal Dicke state and violates a witness detecting genuine six-qubit entanglement by 4 standard deviations. We confirm characteristic Dicke properties of our resource and demonstrate its versatility by projecting out four- and five-photon Dicke states, as well as four-photon Greenberger-Horne-Zeilinger and W states. We also show that Dicke states have interesting applications in multiparty quantum networking protocols such as open-destination teleportation, telecloning, and quantum secret sharing.
ChemInform Abstract: Diastereotopic Group Selectivity at a Prostereogenic Carbon Center: Synthesis of (.+‐.)‐syn‐4,8‐Dimethyldecanal. (1987)

Abstract The synthesis of the aldehyde (VII) mentioned in the title is described.
Annihilation of Methicillin-resistant Staphylococcus aureus via Photobleaching of Staphyloxanthin (2017)

Given that the dearth of new antibiotic development loads an existential burden on successful infectious disease therapy 1 , health organizations are calling for alternative approaches to combat methicillin-resistant Staphylococcus aureus (MRSA) infections. Here, we report a drug-free photonic approach to eliminate MRSA through photobleaching of staphyloxanthin, an indispensable membrane-bound antioxidant of S. aureus 2-5 . The photobleaching process, uncovered through a transient absorption imaging study and quantitated by absorption spectroscopy and mass spectrometry, decomposes staphyloxanthin and sensitizes MRSA to reactive oxygen species attack. Consequently, staphyloxanthin bleaching by low-level blue light eradicates MRSA synergistically with external or internal reactive oxygen species. The effectiveness of this synergistic therapy is validated in MRSA culture, MRSA-infected macrophage cells, S. aureus biofilms, and a mouse wound infection model. Collectively, these findings highlight broad applications of staphyloxanthin photobleaching for treatment of MRSA infections.
ChemInform Abstract: SYNTHESES OF METAL CARBONYLS. XVI. METAL‐METAL MULTIPLE BONDS: SYNTHESIS, CRYSTAL AND MOLECULAR STRUCTURE OF TRI‐μ‐CARBONYL‐BIS((η5‐PENTAMETHYLCYCLOPENTADIENYL)MANGANESE)(MN.TPLBOND# .MN) ‐ THE FIRST MANGANESE‐MANGANESE TRIPLE BOND (1984)

Abstract Syntheses of MetalCarbonyls.
CapNet (2018)

As the scale and density of data centers continue to grow, cost-effective data center management (DCM) is becoming a significant challenge for enterprises hosting large-scale online and cloud services. Machines need to be monitored, and the scale of operations mandates an automated management with high reliability and real-time performance. The limitations of today’s typical DCM network are many-fold. Primarily, it is a fixed wired network, and hence scaling it for a large number of servers increases its cost. In addition, with server densities increasing over recent years, this network also has to be cabled correctly and the management of this network parallels the complexity of managing a data network, since it needs to be networked with multiple switches and routers. In this article, we propose a wireless sensor network as a cost-effective networking solution for DCM while satisfying the reliability and latency performance requirements of DCM. We have developed CapNet, a real-time wireless sensor network for power capping, a time-critical DCM function for power management in a cluster of servers. CapNet employs an efficient event-driven protocol that triggers data collection only on the detection of a potential power capping event. We deploy and evaluate CapNet in a data center. Using server power traces, our experimental results on a cluster of 480 servers inside the data center show that CapNet can meet the real-time requirements of power capping. CapNet demonstrates the feasibility and efficacy of wireless sensor networks for time-critical DCM applications.
ChemInform Abstract: A Simple Method for the Oxidation of α‐Amino Acid Esters to α‐Oximino Esters. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hands-on cybersecurity exercises and the rave virtual environment (abstract only) (2013)

This workshop is intended for anyone who would like to use hands-on exercises in cybersecurity for a variety of classes including Networking, OS, Computer Security and Software Engineering. It has received increased attention nationally in the proposed ACM/IEEE CS2013 Curricula Guidelines. The goal of this workshop is to provide faculty with varied backgrounds (including none) in this area with some tools and interactive exercises to facilitate incorporating this knowledge area into their curriculum. We believe that it is important that students develop analytical skills, thus we include an introduction to EDURange1 and the Hacker Curriculum principles: (1) understanding failure modes and (2) seeing across or through layers of abstraction according to a particular scenario. We will guide attendees through exercises tailored to their level and interests. The exercises will include port scanning and setting up a firewall. These can be done at a range of levels from beginner to advanced. We will include an introduction to tools for packet inspection, which is an important part of analysis. Attendees will receive accounts on the RAVE2 with exercises that they can take back and use immediately with their classes. RAVE provides a number of VMs pre-configured for the exercises. RAVE is also a general purpose technology for other hands-on exercises. Laptop required.
Relationships Between Surface Viscosity, Monolayer Phase Behavior, and the Stability of Lung Surfactant Monolayers (2008)

This chapter reviews how lipid chemistry and lateral organization in monolayers affect surface viscosity, how phase separation and more macroscopic organization influence the flow properties of monolayers, and the effects of lung surfactant specific proteins on the surface viscosity. The surface rheology of the clinical lung surfactants Survanta, Curosurf, and Infasurf is presented and correlated to the lipid and protein composition and phase behavior of these mixtures, and a new hypothesis on the optimal surface viscosity of a lung surfactant film is proposed. It could be that the necessary changes in surface viscosity in lung surfactant films arise from changes in monolayer phase behavior that occur with increasing surface pressure. Many phospholipids, including dipalmitoyl phosphatidylcholine (DPPC), have less-ordered phases at low surface pressures, with short-range molecular correlations. As the surface pressure increases to levels expected in the lungs, solid phases, with long-range molecular correlations, forms.
Ethical Issues Surrounding Fertility Preservation in Cancer Patients (2010)

Fertility preservation is a newly developed branch of reproductive medicine aimed at preserving the potential for genetic parenthood in adults of reproductive age or children, who are at risk of sterility before undergoing anticancer treatments. Except for embryo and semen freezing, all the available options to preserve fertility are considered experimental and thus, they raise ethical issues. In this study, we reviewed the informed consent and the risk-benefit analysis of offering experimental procedures for both adults and children when they are in vulnerable situations. In particular, children represent a special category of patients and their assent to treatment to be sought at anytime should be possible. Overall, there should be no ethical objections to offer these services as they are offered with the scope of preserving future fertility.
Independently addressable InGaAs/GaAs vertical-cavity surface-emitting laser arrays (1991)

The fabrication of an 8 × 8 independently addressable InGaAs/GaAs vertical-cavity surface-emitting laser array based on planar ion-implantation processes is described. The uniformity of laser characteristics across the array under both pulsed and CW operation is discussed. Simultaneous addressing of multiple lasers is demonstrated.
Estimation of Nonparametric Autoregressive Time Series Models Under Dynamical Constraints (2005)

Abstract. A method is introduced to estimate nonparametric autoregressive models under the additional constraint that its regression function has a stable cycle. It is based on a penalty approach that chooses a series expansion approximation taking into account both goodness‐of‐fit and fulfillment of the constraint. Consistency of the proposed estimator is obtained under general hypothesis. Feasibility and effective performance of the introduced method are studied through simulated examples and electro‐encephalographic data collected from a subject suffering from epilepsy.
The development of a compression and kink resistant nerve guide for the treatment of painful neuromas (2016)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
Outcomes of isolated tricuspid valve replacement: a systematic review and meta-analysis of 5,316 patients from 35 studies (2022)

This meta-analysis provides an overview of the historical clinical outcomes following isolated surgical TVR. These findings can support the development of future clinical trials in the tricuspid space by providing thresholds for clinical outcomes.
Recherches sur les proteines phosphatases de l'ovocyte de xenope. Purification d'une serine/threonine phosphatase et etude de la regulation de son activite de tyrosine phosphatase (1990)

La transition g2/m du cyle cellulaire est controlee par des reactions post-traductionnelles de phosphorylation/dephosphorylation de proteines. Dans le cadre de l'etude des enzymes qui controlent les phosphorylations des proteines de l'ovocyte de xenope au cours de la reprise de la meiose, nous avons purifie une proteine tyrosine phosphatase. Cette enzyme a une activite de tyrosine phosphatase qui peut etre stimulee in vitro par trois differents effecteurs: 1) l'atp libre; 2) la tubuline, 3) ptpa une proteine decrite pour la premiere fois qui permet de stimuler l'activite tyrosine phosphatase de l'enzyme par un mecanisme dependant de l'atp, mg
Prolonged Duration Local Anesthesia by Combined Delivery of Capsaicin- and Tetrodotoxin-Loaded Liposomes (2019)

The combination of encapsulated tetrodotoxin and capsaicin achieved marked prolongation of nerve block. This combination did not cause detectable local or systemic toxicity. Capsaicin may be useful for its synergistic effects on other formulations even when used in very small, safe quantities.
Efficient Antenna Tracking Algorithm for HAPS Ground Station in Millimeter-Wave (2022)

In this paper, we propose a tracking system for high-altitude platform (HAPS) ground station in millimeter-wave bands and validate the tracking system through fundamental experiments. In millimeter wave bands with large propagation loss, such as 38 GHz band, a HAPS ground station must accurately track a fluctuating HAPS and must operate with lower power consumption for HAPS in long time flight. Conventional tracking systems control a mechanically driven gimbal equipped with an aperture antenna or operate an active electronically scanned antenna, which have problems such as higher power consumption or high cost. The proposed tracking system in ground station consists of a mechanically driven gimbal, an array feeder, and dielectric lens antenna and operates cooperatively. Compared to the conventional tracking system, the proposed system has the characteristics of low power consumption, low cost, high gain, and plain composition. Through fundamental experiments substituting a simulated gimbal and a XY-stage for the mechanically driven gimbal and the array antenna, it has been quantitatively shown that the proposed tracking system can reduce the amount of operation of the mechanically driven gimbal with high power consumption.
Efficient wave type fingerprinting and filtering by six-component polarization analysis (2022)

We present a technique to automatically classify the wave type of seismic phases that are recorded on a single six-component recording station (measuring both three components of translational and rotational ground motion) at the earth's surface. We make use of the fact that each wave type leaves a unique 'fingerprint' in the six-component motion of the sensor. This fingerprint can be extracted by performing an eigenanalysis of the data covariance matrix, similar to conventional three-component polarization analysis. To assign a wave type to the fingerprint extracted from the data, we compare it to analytically derived six-component polarization models that are valid for pure-state plane wave arrivals. For efficient classification, we make use of the supervised machine learning method of support vector machines that is trained using data-independent, analytically-derived six-component polarization models. This enables the rapid classification of seismic phases in a fully automated fashion, even for large data volumes, such as encountered in land-seismic exploration or ambient noise seismology. Once the wave-type is known, additional wave parameters (velocity, directionality, and ellipticity) can be directly extracted from the six-component polarization states without the need to resort to expensive optimization algorithms. We illustrate the benefits of our approach on various real and synthetic data examples for applications such as automated phase picking, aliased ground-roll suppression in land-seismic exploration, and the rapid close-to real time extraction of surface wave dispersion curves from single-station recordings of ambient noise. Additionally, we argue that an initial step of wave type classification is necessary in order to successfully apply the common technique of extracting phase velocities from combined measurements of rotational and translational motion.
Performance under tensile loading of point-by-point wire and arc additively manufactured steel bars for structural components (2021)

The point-by-point wire and arc additive manufacturing technology allows precisely depositing of high strength material. In combination with a robotic arm and sensing techniques during printing, it can be used as a novel efficient joining method for custom structural steel components. For accessibility to the parts to be joined, flexibility on the orientation of the printing tool is of high significance. In this contribution, the focus is set on the influence of different printing orientations on relevant properties of point-by-point wire and arc additively manufactured steel bars. Geometry scans show an irregular variation of the cross-section area along the length of the bars. The mechanical properties of the bars are determined from uniaxial tensile tests on as-printed specimens and on locally milled specimens. It is shown, that different printing orientations have an influence on the geometry of the bars, but only a negligible effect on their mechanical properties. The results of the uniaxial tensile tests indicate a good suitability of the additively manufactured steel bars for structural applications. Finite element simulations validate a proposed elastic-plastic material model, which allows predicting the structural behaviour of the point-by-point wire and arc additively manufactured steel bars produced with different printing orientations.
OS02F023 Picosecond Ultrasound Spectroscopy for High Purity Boron Nitrides (2011)

Brillouin oscillations appear when a light pulse is diffracted in a solid by an acoustic strain pulse propagating inside the solid, and its frequency reflects elasticity of the solid. In this study, we succeeded in observing Brillouin oscillation signals for cubic boron nitride(cBN) and wurtzite boron nitride(wBN) using picosecond ultrasound spectroscopy. We developed two different optics systems using a titanium-sapphire pulse laser and a fiber laser, and adopted Al and Pt ultrathin films on the specimen surfaces as the ultrasonic sources. Although the vibration of the deposited thin film overlapped on the Brillouin oscillation, we finally succeeded in identifying the Brillouin oscillation signal and in determining the frequency.
Shiny (2014)

We describe an activity logging platform for Google Glass based on our previous work. We introduce new multi-modal methods for quick non-disturbing interactions for activity logging control and real time ground truth labeling, consisting of swipe gesture, head gesture and laser pointer tagging methods. The methods are evaluated in user studies towards estimating their effectiveness.
A Mistuning-Tolerant and Controllable Power Supply for Roadway Wireless Power Systems (2016)

Inductive power transfer power supplies for electric vehicle charging in dynamic applications need to tolerate large variations in coupling and tuning with varying loads. This paper investigates the use of a buck converter to regulate the input voltage to a fixed frequency unidirectional switch push-pull converter to meet the requirements of dynamic charging. The presented circuit is optimized to remove some of the additional components introduced. A mathematical model is presented that shows the circuit is capable of operating while extremely mistuned in both the inductive and capacitive regions while maintaining sinusoidal currents. A controller design is also presented allowing constant primary current operation, safe start up, and operation under no load conditions. A 5-kW prototype was built and validated when operated with a dynamic load under severely mistuned conditions.
Catalytic Asymmetric Synthesis: Sections 2.1.4 ‐ 2.1.6 (2007)

This chapter contains sections titled: Palladium-Catalyzed Allylic Alkylation of Sulfur and Oxygen Nucleophiles – Asymmetric Synthesis, Kinetic Resolution and Dynamic Kinetic Resolution Introduction Asymmetric Synthesis of Allylic Sulfones and Allylic Sulfides and Kinetic Resolution of Allylic Esters Kinetic Resolution Selectivity Asymmetric Synthesis Synthesis of Enantiopure Allylic Alcohols Asymmetric Rearrangement and Kinetic Resolution of Allylic Sulfinates Introduction Synthesis of Racemic Allylic Sulfinates Pd-Catalyzed Rearrangement Kinetic Resolution Mechanistic Considerations Asymmetric Rearrangement of Allylic Thiocarbamates Introduction Synthesis of Racemic O-Allylic Thiocarbamates Acyclic Carbamates Cyclic Carbamates Mechanistic Considerations Synthesis of Allylic Sulfides Asymmetric Synthesis of Allylic Thioesters and Kinetic Resolution of Allylic Esters Introduction Asymmetric Synthesis of Allylic Thioesters Kinetic Resolution of Allylic Esters Memory Effect and Dynamic Kinetic Resolution of the Five-Membered Cyclic Acetate Asymmetric Synthesis of Cyclopentenyl Thioacetate Kinetic and Dynamic Kinetic Resolution of Allylic Alcohols Introduction Asymmetric Synthesis of Symmetrical Allylic Alcohols Asymmetric Synthesis of Unsymmetrical Allylic Alcohols Asymmetric Synthesis of a Prostaglandin Building Block Investigation of an Unsaturated Analogue of BPA Conclusions The QUINAPHOS Ligand Family and its Application in Asymmetric Catalysis Introduction Synthetic Strategy Stereochemistry and Coordination Properties Free Ligands Complexes Catalytic Applications Rhodium-Catalyzed Asymmetric Hydroformylation of Styrene Rhodium-Catalyzed Asymmetric Hydrogenation of Functionalized Alkenes Ruthenium-Catalyzed Asymmetric Hydrogenation of Aromatic Ketones Copper-Catalyzed Enantioselective Conjugate Addition of Diethylzinc to Enones Nickel-Catalyzed Asymmetric Hydrovinylation Nickel-Catalyzed Cycloisomerization of 1,6-Dienes Conclusions Immobilization of Transition Metal Complexes and Their Application to Enantioselective Catalysis Introduction Immobilized Rh Diphosphino Complexes as Catalysts for Asymmetric Hydrogenation Preparation and Characterization of the Immobilized Rh–Diphosphine Complexes Enantioselective Hydrogenation over Immobilized Rhodium Diphosphine Complexes Heterogeneous Asymmetric Epoxidation of Olefins over Jacobsen's Catalyst Immobilized in Inorganic Porous Materials Preparation and Characterization of Immobilized Jacobsen’s Catalysts Epoxidation of Olefins over Immobilized Jacobsen Catalysts Novel Heterogenized Catalysts for Asymmetric Ring-Opening Reactions of Epoxides Synthesis and Characterization of the Heterogenized Catalysts Asymmetric Ring Opening of Epoxides over New Heterogenized Catalysts Conclusions
Osmotic pressure-dependent release profiles of payloads from nanocontainers by co-encapsulation of simple salts (2016)

The encapsulation of payloads in micro- to nano-scale capsules allows protection of the payload from the surrounding environment and control of its release profile. Herein, we program the release of hydrophilic payloads from nanocontainers by co-encapsulating simple inorganic salts for adjusting the osmotic pressure. The latter either leads to a burst release at high concentrations of co-encapsulated salts or a sustained release at lower concentrations. Osmotic pressure causes swelling of the nanocapsule's shell and therefore sustained release profiles can be adjusted by crosslinking it. The approach presented allows for programing the release of payloads by co-encapsulating inexpensive salts inside nanocontainers without the help of stimuli-responsive materials.