gebhart/patrepeval huggingface dataset:
Segment-Based EVPN(S-EVPN) (2014)

This document proposes an enhanced EVPN mechanism, segment-based EVPN
(S-EVPN). It satisfies the requirements of PBB-EVPN but does not
require PBB implementation on PE. The solution uses a global label for
each Ethernet Segment (ES) in an EVPN. It inserts the source ES label
into packets at ingress PE and learns C-MAC and source ES label
binding at egress PE. The solution makes the implementation easier and
closer to E-VPN compared to PBB-EVPN but has the PBB-EVPN benefits.
Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue (2016)

Multipotent mesenchymal stem/stromal cells (MSC) were conventionally isolated, through their plastic adherence, from primary tissue digests whilst their anatomical tissue location remained unclear. The recent discovery of defined perivascular and MSC cell marker expression by perivascular cells in multiple tissues by our group and other researchers has provided an opportunity to prospectively isolate and purify specific homogenous subpopulations of multipotent perivascular precursor cells. We have previously demonstrated the use of fluorescent activated cell sorting (FACS) to purify microvascular CD146<sup>+</sup>CD34<sup>-</sup> pericytes and vascular CD34<sup>+</sup>CD146<sup>-</sup> adventitial cells from human skeletal muscle. Herein we describe a method to simultaneously isolate these two perivascular cell subsets from human myocardium by FACS, based on the expression of a defined set of cell surface markers for positive and negative selections. This method thus makes available two specific subpopulations of multipotent cardiac MSC-like precursor cells for use in basic research and/or therapeutic investigations.
Challenges and opportunities for adsorption-based CO2 capture from natural gas combined cycle emissions (2019)

In recent years, the power sector has shown a growing reliance on natural gas, a cleaner-burning fuel than coal that emits approximately half as much CO<sub>2</sub> per kWh of energy produced. This rapid growth in the consumption of natural gas has led to increased CO<sub>2</sub> emissions from gas-fired power plants. To limit the contribution of fossil fuel combustion to atmospheric CO<sub>2</sub> levels, carbon capture and sequestration has been proposed as a potential emission mitigation strategy. However, despite extensive exploration of solid adsorbents for CO<sub>2</sub> capture, few studies have examined the performance of adsorbents in post-combustion capture processes specific to natural gas flue emissions. In this perspective, we emphasize the importance of considering gas-fired power plants alongside coal-fired plants in future analyses of carbon capture materials. We address specific challenges and opportunities related to adsorptive carbon capture from the emissions of gas-fired plants and discuss several promising candidate materials. Finally, we suggest experiments to determine the viability of new CO<sub>2</sub> capture materials for this separation. This broadening in the scope of current carbon capture research is urgently needed to accelerate the deployment of transformational carbon capture technologies.
Supplementary File from AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small-Cell Lung Cancer (2023)

&lt;p&gt;Tissue expression datasets&lt;/p&gt;
Internal homologies in the two aspartokinase-homoserine dehydrogenases of Escherichia coli K-12. (1984)

In Escherichia coli, AK I- HDH I and AK II- HDH II are two bifunctional proteins, derived from a common ancestor, that catalyze the first and third reactions of the common pathway leading to threonine and methionine. An extensive amino acid sequence comparison of both molecules reveals two main features on each of them: (i) two segments, each of about 130 amino acids, covering the first one-third of the polypeptide chain, are similar to each other and (ii) two segments, each of about 250 amino acids and covering the COOH-terminal 500 amino acids also present a significant homology. These findings suggest that these two regions may have evolved independently of each other by a process of gene duplication and fusion previous to the appearance of an ancestral aspartokinase-homoserine dehydrogenase molecule.
Recent advances in liquid-metal-based wearable electronics and materials (2021)

Soft wearable electronics are rapidly developing through exploration of new materials, fabrication approaches, and design concepts. Although there have been many efforts for decades, a resurgence of interest in liquid metals (LMs) for sensing and wiring functional properties of materials in soft wearable electronics has brought great advances in wearable electronics and materials. Various forms of LMs enable many routes to fabricate flexible and stretchable sensors, circuits, and functional wearables with many desirable properties. This review article presents a systematic overview of recent progresses in LM-enabled wearable electronics that have been achieved through material innovations and the discovery of new fabrication approaches and design architectures. We also present applications of wearable LM technologies for physiological sensing, activity tracking, and energy harvesting. Finally, we discuss a perspective on future opportunities and challenges for wearable LM electronics as this field continues to grow.
Yet Another Sanitizable Signature from Bilinear Maps (2009)

The sanitizable signature attracts much attention since it allows to modify the original document for hiding partial information with keeping the validity of the signature and the integrity of unmodified parts of the document. The sanitizable signature is quite useful in governmental or military offices where there is a dilemma between is closure laws for public documents and privacy or diplomatic secrets. This paper proposes two new sanitizable signature schemes from bilinear maps with a new structure.
Holbrook Kohrt: In Memoriam (1977–2016) (2016)

International audience
Error Analysis of Receive Diversity Noncoherent PLC System in Impulsive Noise Environment (2018)

A noncoherent diversity detection power line communication (PLC) system employing multi-level amplitude-shift keying (ASK) modulation in the presence of Middleton Class-A impulsive noise is considered. Hermite numerical integration technique is used iteratively to obtain the statistics of the decision variable of an asymptotically optimal detector, which is utilized to derive series expressions for the symbol error probability (SEP). Numerical optimization of the ASK levels is done to achieve the minimum SEP, which results in the optimal solution being close to the equally spaced ASK constellation. The asymptotic optimality of the proposed detector is validated by the SEP variation with the impulsive index of the noise.
Rapid mixed lymphocyte culture testing by analysis of the insulin receptor on alloactivated T lymphocytes: implications for human tissue typing. (1981)

Responses in the mixed lymphocyte culture (MLC) are traditionally evaluated by measurement of DNA synthesis or blast transformation. However, these events occur too late in the MLC to permit prospective matching for cadaveric renal transplantation. Presentation of allogeneic cells to the T lymphocyte within the MLC results in the emergence of an insulin receptor pharmacokinetically similar to that on other tissues such as fat, liver, and muscle. Intrafamilial MLC were studied by simultaneous assessment of DNA synthesis and insulin receptor binding. In 68 studies from seven families that provide examples of two haplotype identical matches, haplo-identical matches and total haplo mismatches, the presence of an insulin receptor correlated in every case with a positive MLC as estimated by [3H]thymidine incorporation. A quantitative relationship existed between the strength of the MLC and the amount of receptor binding. Based on analysis of cells from several families in which crossover events were known to have occurred, the appearance of an insulin receptor always corresponded with a mismatch at the portion of histocompatibility leukocyte antigen (HLA) chromosome bearing the D region. Finally, it was demonstrated in each of 30 cultures that insulin receptor emergence occurred significantly before detectable DNA synthesis, as early as 24 h after the initiation of the MLC, well within the time-constraint limitations for renal preservation. Appearance of the insulin receptor on activated lymphocytes may be a more rapid measure of mixed lymphocyte responses, and should permit prospective matching for cadaveric renal transplantation.
Inorganic Nitrate in Angina Study: A Randomized Double‐Blind Placebo‐Controlled Trial (2017)

URL: https://www.clinicaltrials.gov/. Unique identifier: NCT02078921. EudraCT number: 2012-000196-17.
Two-inch-Diameter Magneto-optical Disk System with 3 GB Capacity and 24 Mbps Data Transfer Rate Using a Red Laser (2002)

Abstract-High-density recording four times that of a current DVD-RAM has been achieved by applying Domain Wall Displacement Detection (DWDD) technology using a conventional optical head which has the same wavelength of 660 nm and NA of 0.6 as the DVD head. It has been confirmed by using a sampled servo and PRML that a recording density of 15 Gbit/inch2 with a track pitch of 540nm and bit length of 80 nm has sufficient system margin. This means that a capacity of 3 GB on a two-inch-diameter disk is now available for portable use. If applied to a digitalvideo camera, one hour of MPEG2 video contents can be recorded at a transfer rate of 6 Mbps.
Newly established myeloma-derived stromal cell line MSP-1 supports multiple myeloma proliferation, migration, and adhesion and induces drug resistance more than normal-derived stroma (2016)

The effects of a normal bone marrow (BM) microenvironment compared to a malignant microenvironment on multiple myeloma (MM) are significantly different, where BM stromal cells (BMSCs) play a key role. We established, characterized and compared a myeloma-derived stromal cell line (Myeloma Stromal Puente-1, MSP-1) with two normal stromal cell lines (HS-5 and HS-27A). MSP-1 was found to affect MM proliferation, adhesion, migration and drug resistance in a more profound manner than HS-5 and HS-27A. These results demonstrated the importance of malignant versus normal BM microenvironment on several key MM processes, providing a new myeloma-derived stromal cell line to study the effect of tumor microenvironment on MM.
Isostructural organic binary-host frameworks with tuneable and diversely decorated inclusion cavities (2012)

The search for materials capable of storing small molecular species is experiencing a shift from solids with permanent porosity towards organic materials capable of the uptake and release of low-molecular-weight guests. We demonstrate that a solid mixture of the pharmaceutical compound lamotrigine with a range of saturated and unsaturated 1,4-butanedicarboxylic acids, when in combination with a third molecule, can result in the formation of a family of isostructural materials involving a structurally persistent binary-host framework based on a hydrogen-bonded molecular salt of lamotrigine and the acid. A systematic study, based on mechanochemical screening, has revealed a remarkable robustness to subtle changes in the chemical functionality of the acid in that at least 12 different acids can be used in combination with lamotrigine to generate isostructural binary-host frameworks. Such robust isostructurality results in the important attribute that the shape, size and surface chemistry of the inclusion cavities can be fine-tuned by systematic variation of the substituents on the dicarboxylic acid.
Challenges and Opportunities in Securing the Industrial Internet of Things (2020)

Given the tremendous success of the Internet of Things in interconnecting consumer devices, we observe a natural trend to likewise interconnect devices in industrial settings, referred to as industrial Internet of Things or Industry 4.0. While this coupling of industrial components provides many benefits, it also introduces serious security challenges. Although sharing many similarities with the consumer Internet of Things, securing the industrial Internet of Things introduces its own challenges but also opportunities, mainly resulting from a longer lifetime of components and a larger scale of networks. In this article, we identify the unique security goals and challenges of the industrial Internet of Things, which, unlike consumer deployments, mainly follow from safety and productivity requirements. To address these security goals and challenges, we provide a comprehensive survey of research efforts to secure the industrial Internet of Things, discuss their applicability, and analyze their security benefits.
Observation of Annealing-Induced Doping in TiO2 Mesoporous Single Crystals for Use in Solid State Dye Sensitized Solar Cells (2013)

Mesoporous single crystals (MSCs) of TiO2 are promising materials for more efficient dye sensitized solar cells and other energy conversion or storage devices, since they combine high surface area with large crystalline domain size. In this work, we investigate the charge transport properties of TiO2 MSCs after annealing them within a confining template at temperatures from 500 to 850 °C. We observe that higher anneal temperatures do not change the crystal phase, as in nanocrystalline TiO2, but do influence the MSC absorption spectrum in a manner consistent with the signature of increased oxygen-vacancy defects. By comparing MSC film conductivity in vacuum and in air, we infer that these anneal-induced defects increase the background charge density in TiO2. Subsequently, we measure higher effective mobility in annealed MSCs using transient mobility spectroscopy (TMS), consistent with higher anneal temperatures filling sub-bandgap trap states by n-doping TiO2. Finally, we measure faster charge transport rates in solid-state dye sensitized solar cells as well as increased open-circuit voltages at low light intensity with increasing MSC anneal temperature. This study leverages the fixed geometry and crystal phase of MSCs under thermal treatment to identify and isolate the doping effect of annealing at high temperature, previously inaccessible for mesoporous anatase TiO2. The results offer insight into the influence of doping on charge transport in TiO2-based solar cells and the tunability of MSCs for use in enhancing device performance.
FEM simulation and its application in MEMS design (2011)

This paper presents the simulated static and dynamic properties of a micro capacitive transducer by using commercial FEM software - ANSYS. Evaluation of the stress distribution in the stretched membrane of the transducer indicates that the location of the access holes plays an important role for reliable device fabrication and operation. Acoustic simulation shows that the pressure variation in the radiation field of a piston source can be explicitly demonstrated. Experiment results validate the effectiveness of FEM simulation as a useful tool for the design of MEMS devices and rough estimation of their properties.
"Hands Busy, Eyes Busy": Generating Stories from Sensor Data for Automotive applications (2011)

This paper examines the potential of using natural language generation to support “hands busy, eyes busy” automotive applications. It outlines a hierarchy of complexity of output text, and the type of sensor data that may be collected. It also suggests a number of ways natural language generation can generate narrative events from sensor data for drivers.
JAK–STAT Pathway Activation in Malignant and Nonmalignant Cells Contributes to MPN Pathogenesis and Therapeutic Response (2015)

Our results demonstrate that JAK-STAT3-mediated cytokine production from malignant and nonmalignant cells contributes to MPN pathogenesis and that JAK inhibition in both populations is required for therapeutic efficacy. These findings provide novel insight into the mechanisms by which JAK kinase inhibition achieves therapeutic efficacy in MPNs.
Small molecule schweinfurthins selectively inhibit cancer cell proliferation and mTOR/AKT signaling by interfering with trans-Golgi-network trafficking (2015)

Natural compound schweinfurthins are of considerable interest for novel therapy development because of their selective anti-proliferative activity against human cancer cells. We previously reported the isolation of highly active schweinfurthins E-H, and in the present study, mechanisms of the potent and selective anti-proliferation were investigated. We found that schweinfurthins preferentially inhibited the proliferation of PTEN deficient cancer cells by indirect inhibition of AKT phosphorylation. Mechanistically, schweinfurthins and their analogs arrested trans-Golgi-network trafficking, an intracellular vesicular trafficking system, resulting in the induction of endoplasmic reticulum stress and the suppression of both lipid raft-mediated PI3K activation and mTOR/RheB complex formation, which collectively led to an effective inhibition of mTOR/AKT signaling. The trans-Golgi-network traffic arresting effect of schweinfurthins was associated with their in vitro binding activity to oxysterol-binding proteins that are known to regulate intracellular vesicular trafficking. Moreover, schweinfurthins were found to be highly toxic toward PTEN-deficient B cell lymphoma cells, and displayed 2 orders of magnitude lower activity toward normal human peripheral blood mononuclear cells and primary fibroblasts in vitro. These results revealed a previously unrecognized role of schweinfurthins in regulating trans-Golgi-network trafficking, and linked mechanistically this cellular effect with mTOR/AKT signaling and with cancer cell survival and growth. Our findings suggest the schweinfurthin class of compounds as a novel approach to modulate oncogenic mTOR/AKT signaling for cancer treatment.
Tuning Range Extension of a Transformer-Based Oscillator Through Common-Mode Colpitts Resonance (2017)

In this paper, we propose a method to broaden a tuning range of a CMOS LC-tank oscillator without sacrificing its area. The extra tuning range is achieved by forcing a strongly coupled transformer-based tank into a common-mode resonance at a much higher frequency than in its main differential-mode oscillation. The oscillator employs separate active circuits to excite each mode but it shares the same tank, which largely dominates the core area but is on par with similar single-core designs. The tank is forced in common-mode oscillation by two injection locked Colpitts oscillators at the transformer's primary winding, while a two-port structure provides differential-mode oscillation. An analysis is also presented to compare the phase noise performance of the dual-core oscillator in common-mode and differential-mode excitations. A prototype implemented in digital 40-nm CMOS verifies the dual-mode oscillation and occupies only 0.12 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and measures 56% tuning range.
Pyrenebutyrate Leads to Cellular Binding, Not Intracellular Delivery, of Polyarginine Quantum Dots (2010)

The intracellular, cytosolic, delivery of quantum dots is an important goal for cellular imaging. Recently, a hydrophobic anion, pyrenebutyrate had been proposed to serve as a delivery agent for cationic quantum dots as characterized by confocal microscopy. Using an extracellular quantum dot quencher, QSY-21, as an alternative to confocal microscopy, we demonstrate that quantum dots remain on the cell surface and do not cross the plasma membrane following pyrenebutyrate treatment, a result that is confirmed with transmission electron microscopy. Pyrenebutyrate leads to increased cellular binding of quantum dots rather than intracellular delivery. These results characterize the use of QSY-21 as a quantum dot quencher and highlight the importance of the use of complementary techniques when using confocal microscopy.
Role of a-Synuclein in the GFAP.HMOX1 mouse model of PD (P3.058) (2018)

To determine whether alpha-synuclein (α-Syn) mediates the dystrophic effects of glial heme oxygenase-1 (HO-1) overexpression in parkinsonian GFAP.HMOX1 mice.
Recognition of 2020 Transactions and Magazine Paper Reviewers (2021)

Presents the list of reviewers who contributed to this publication in 2020.
Analog man-in-the-middle attack against link-based packet source identification (2016)

A novel attack model is proposed against the existing wireless link-based source identification, which classifies packet sources according to the physical-layer link signatures. A link signature is believed to be a more reliable indicator than an IP or MAC address for identifying packet source, as it is generally harder to modify/forge. It is therefore expected to be a future authentication against impersonation and DoS attacks. However, if an attacker is equipped with the same capability/hardware as the authenticator to process physical-layer signals, a link signature can be easily manipulated by any nearby wireless device during the training phase. Based on this finding, we propose an attack model, called the analog man-in-the-middle (AMITM) attack, which utilizes the latest full-duplex relay technology to inject semi-controlled link signatures into authorized packets and reproduce the injected signature in the fabricated packets. Our experimental evaluation shows that with a proper parameter setting, 90% of fabricated packets are classified as those sent from an authorized transmitter. A countermeasure against this new attack is also proposed for the authenticator to inject link-signature noise by the same attack methodology.
[Identification of syndromes using a combined computer and video program]. (1990)

The use of the database POSSUM (Pictures of Standard Syndromes and Undiagnosed Malformations) was evaluated over a period of 1 1/2 years in 49 children with multiple congenital anomalies. A specific diagnosis was obtained in 23 cases and POSSUM contributed significantly to a diagnosis in 13 cases. We conclude that a computerized approach is valuable in the evaluation of dysmorphic syndromes.
Dysfunctional Mitochondrial Dynamics in the Pathophysiology of Neurodegenerative Diseases (2013)

Mitochondrial dysfunction occurs in neurodegenerative diseases, however molecular mechanisms underlying this process remain elusive. Emerging evidence suggests that nitrosative stress, mediated by reactive nitrogen species (RNS), may play a role in mitochondrial pathology. Here, we review findings that highlight the abnormal mitochondrial morphology observed in many neurode-generative disorders including Alzheimer's, Parkinson's, and Huntington's diseases. One mechanism whereby RNS can affect mitochondrial function and thus neuronal survival occurs via protein S-nitrosylation, representing chemical reaction of a nitric oxide (NO) group with a critical cysteine thiol. In this review, we focus on the signaling pathway whereby S-nitrosylation of the mitochondrial fission protein Drp1 (dynamin-related protein 1; forming S-nitrosothiol (SNO)-Drp1) precipitates excessive mitochondrial fission or fragmentation and consequent bioenergetic compromise. Subsequently, the formation of SNO-Drp1 leads to synaptic damage and neuronal death. Thus, intervention in the SNO-Drp1 pathway may provide therapeutic benefit in neurodegenerative diseases.