gebhart/patrepeval huggingface dataset:
Data Anonymization for Hiding Personal Tendency in Set-Valued Database Publication (2019)

Set-valued database publication has been increasing its importance recently due to its benefit for various applications such as marketing analysis and advertising. However, publishing a raw set-valued database may cause individual privacy breach such as the leakage of sensitive information like personal tendencies when data recipients perform data analysis. Even though imposing data anonymization methods such as suppression-based methods and random data swapping methods to such a database can successfully hide personal tendency, it induces item loss from records and causes significant distortion in record structure that degrades database utility. To avoid the problems, we proposed a method based on swapping technique where an individual’s items in a record are swapped to items of the other record. Our swapping technique is distinct from existing one called random data swapping which yields much structure distortion. Even though the technique results in inaccuracy at a record level, it can preserve every single item in a database from loss. Thus, data recipients may obtain all the item information in an anonymized database. In addition, by carefully selecting a pair of records for item swapping, we can avoid excessive record structure distortion that leads to alter database content immensely. More importantly, such a strategy allows one to successfully hide personal tendency without sacrificing a lot of database utility.
Supplementary Figure 4 from <i>De Novo</i> Design of a Tumor-Penetrating Peptide (2023)

&lt;p&gt;PDF file - 1MB, iNGR is cleaved upon entering the cells&lt;/p&gt;
Digital and Palmar Dermatoglyphic Patterns among Natives of Extreme Northwest Nepal (1983)

A dermatoglyphic study was made of two high-altitude populations inhabiting the same ecozone in extreme northwest Nepal. Despite cultural and linguistic differences there appears to be a significant amount of dermatoglyphic homology between the Buddhist-Tibetan villages and their Hindu-Caucasian neighbors.
Wide field of view coherent detection (1999)

We present the concept of a wide-field-of-view and atmospheric- distortion-insensitive coherent detection. We propose to mix a local oscillator plane wave and a focused backscattered signal on the detector. In first approximation, the field-of-view is only limited by the size of the detector. An original experimental set- up at (lambda) equals 633 nm is presented to validate this technique. We control the phase of the backscattered signal using a liquid-crystal spatial light modulator (SLM). This permits us to steer or to distort the wave front of the backscattered signal in order to measure and compare the field-of-view and the atmospheric perturbations sensitivity of the two set-ups. We will present the performances (wide field-of-view, distortion sensitivity, . . .) of our architecture.
Lung Epithelial Signaling Mediates Early Vaccine-Induced CD4 + T Cell Activation and Mycobacterium tuberculosis Control (2021)

Tuberculosis (TB) is one of the leading causes of death due to a single infectious agent. The development of a TB vaccine that induces durable and effective immunity to Mycobacterium tuberculosis (<i>Mtb</i>) infection is urgently needed. Early and superior <i>Mtb</i> control can be induced in M. bovis Bacillus Calmette-Guérin (BCG)-vaccinated hosts when the innate immune response is targeted to generate effective vaccine-induced immunity. In the present study, we show that innate activation of DCs is critical for mucosal localization of clonally activated vaccine-induced CD4<sup>+</sup> T cells in the lung and superior early <i>Mtb</i> control. In addition, our study reveals that Th1/Th17 cytokine axis play an important role in superior vaccine-induced immunity. Our studies also show that activation of the nuclear factor kappa-light-chain enhancer of activated B cell (NF-κβ) pathway in lung epithelial cells is critical for the mucosal localization of activated vaccine-induced CD4<sup>+</sup> T cells for rapid <i>Mtb</i> control. Thus, our study provides novel insights into the immune mechanisms that can overcome TB vaccine bottlenecks and provide early rapid <i>Mtb</i> control. <b>IMPORTANCE</b> Tuberculosis is a leading cause of death due to single infectious agent accounting 1.4 million deaths each year. The only licensed vaccine, BCG, is not effective due to variable efficacy. In our study, we determined the early immune events necessary for achieving complete protection in a BCG-vaccinated host. Our study reveals that innate activation of DCs can mediate superior and early <i>Mtb</i> control in BCG-vaccinated mice through lung epithelial cell signaling and localization of clonal activated, <i>Mtb</i> antigen-specific, cytokine-producing CD4<sup>+</sup> T cells within the lung parenchyma and airways. Thus, our study provides novel insights into the immune mechanisms that can overcome TB vaccine bottlenecks and provide early rapid <i>Mtb</i> control.
The spectroscopic observation of water formation (1982)

The formation of water from atomic oxygen and atomic hydrogen coadsorbed on the Pt(111) surface has been characterized by x-ray photoemission (XPS) and temperature programmed reaction (TPR). These studies were performed between 100 and 155 K, which is below the desorption temperature for adsorbed water on the Pt(111) surface. Only adsorbed atomic oxygen and atomic hydrogen were present on the surface prior to reaction. At 100 K no reaction occurs; however, at 120 K the reaction goes to completion even in the absence of gas phase hydrogen. Therefore, water formation on the Pt(111) surface has a low activation energy with an upper limit of 8 kcal/mol (34 kJ/mol). Although previous work has shown that hydroxyl groups are stable near 150 K on the Pt(111) surface, no significant surface concentration of OH species was detected during these reaction studies. The reaction mechanism most consistent with all of the data is the sequential addition of atomic hydrogen to oxygen and then to hydroxyl groups to form the water product. A low surface concentration of OH groups is expected within this mechanism if OH formation is the rate-limiting reaction step.
Excited-State Abundance in Hydrogen Atoms Coming Out of Refractory Metal Surfaces (2011)

Electron transfer between hydrogen atoms and rerractory metal surfaces was studied quantum mechanically [I).The
From Locus to Cellular Disturbances: Positional Cloning of the Infantile Neuronal Ceroid Lipofuscinosis Gene (1997)

Neuronal ceroid lipofuscinoses (NCL) represent a group of common progressive encephalopathies of children with a global incidence of 1 in 12,500. NCL are divided into three autosomal recessive subtypes, all assigned to different chromosomal loci. The infantile subtype of NCL (INCL) is characterized by early visual loss and mental deterioration, and leads to a vegetative state of the patients by 3 years of age. We pursued the identification of the gene defective in INCL, enriched in the Finnish population by a positional cloning approach and identified mutations in the palmitoyl-protein thioesterase (PPT) gene in INCL patients. We have further shown that PPT represents a novel lysosomal enzyme and is routed to the lysosomes via the mannose 6-phosphate receptor-mediated pathway. The worldwide most common mutation in the PPT gene, INCLFin, results in the deficient routing of the mutant PPT to lysosomes and undetectable enzyme activity in the brain tissue of patients. Our results suggest that INCL can be classified as a new member of lysosomal enzyme deficiencies.
The role of mechanical bowel preparation in gynecologic laparoscopy. (2011)

Various combinations of dietary restriction, antibiotic regimens, and mechanical preparations have become routine in preoperative surgical planning for elective colon surgery. This practice has also become commonplace in the field of gynecology, either for planned bowel surgery or in complex cases that are believed to be high risk for inadvertent bowel injury. As the trend in gynecologic surgery shifts toward more minimally invasive approaches, the complexity of cases being performed by laparoscopy and robotics continues to increase. In addition, laparoscopic surgical techniques have a different set of inherent risks and challenges as compared with open pelvic operations. This review summarizes the available data surrounding the use of mechanical bowel preparations, specifically with regard to gynecologic laparoscopy.
RGD-functionalized ultrasmall iron oxide nanoparticles for targeted T1-weighted MR imaging of gliomas (2015)

We report a convenient approach to prepare ultrasmall Fe3O4 nanoparticles (NPs) functionalized with an arginylglycylaspartic acid (RGD) peptide for in vitro and in vivo magnetic resonance (MR) imaging of gliomas. In our work, stable sodium citrate-stabilized Fe3O4 NPs were prepared by a solvothermal route. Then, the carboxylated Fe3O4 NPs stabilized with sodium citrate were conjugated with polyethylene glycol (PEG)-linked RGD. The formed ultrasmall RGD-functionalized nanoprobe (Fe3O4-PEG-RGD) was fully characterized using different techniques. We show that these Fe3O4-PEG-RGD particles with a size of 2.7 nm are water-dispersible, stable, cytocompatible and hemocompatible in a given concentration range, and display targeting specificity to glioma cells overexpressing αvβ3 integrin in vitro. With the relatively high r1 relaxivity (r1 = 1.4 mM(-1) s(-1)), the Fe3O4-PEG-RGD particles can be used as an efficient nanoprobe for targeted T1-weighted positive MR imaging of glioma cells in vitro and the xenografted tumor model in vivo via an active RGD-mediated targeting pathway. The developed RGD-functionalized Fe3O4 NPs may hold great promise to be used as a nanoprobe for targeted T1-weighted MR imaging of different αvβ3 integrin-overexpressing cancer cells or biological systems.
A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer (2020)

Androgen receptor (AR) signaling is the central driver of prostate cancer across disease states. While androgen deprivation therapy (ADT) is effective in the initial treatment of prostate cancer, resistance to ADT or to next-generation androgen pathway inhibitors invariably arises, most commonly through the re-activation of the AR axis. Thus, orthogonal approaches to inhibit AR signaling in advanced prostate cancer are essential. Here, via genome-scale CRISPR-Cas9 screening, we identify protein arginine methyltransferase 1 (PRMT1) as a critical mediator of AR expression and signaling. PRMT1 regulates the recruitment of AR to genomic target sites and the inhibition of PRMT1 impairs AR binding at lineage-specific enhancers, leading to decreased expression of key oncogenes, including AR itself. In addition, AR-driven prostate cancer cells are uniquely susceptible to combined AR and PRMT1 inhibition. Our findings implicate PRMT1 as a key regulator of AR output and provide a preclinical framework for co-targeting of AR and PRMT1 in advanced prostate cancer.
Compare Trailer-Mounted Attenuators vs. Truck-Mounted Attenuators Protection for Workers (2012)

Although many truck-mounted and trailer-mounted attenuators have been accepted for use on the National Highway System, their required testing focused primarily on their structural adequacy, occupant risk for the impacting vehicle, and post-impact vehicular response. For workers that may be located near the attenuators when an impact occurs, the level of protection provided has not been compared. The purpose of this research was to compare truck-mounted and trailer-mounted attenuators in terms of worker safety.
Aurora Kinases as Therapeutic Targets in Head and Neck Cancer (2022)

The Aurora kinases (AURKA and AURKB) have attracted attention as therapeutic targets in head and neck squamous cell carcinomas. Aurora kinases were first defined as regulators of mitosis that localization to the centrosome (AURKA) and centromere (AURKB), governing formation of the mitotic spindle, chromatin condensation, activation of the core mitotic kinase CDK1, alignment of chromosomes at metaphase, and other processes. Subsequently, additional roles for Aurora kinases have been defined in other phases of cell cycle, including regulation of ciliary disassembly and DNA replication. In cancer, elevated expression and activity of Aurora kinases result in enhanced or neomorphic locations and functions that promote aggressive disease, including promotion of MYC expression, oncogenic signaling, stem cell identity, epithelial-mesenchymal transition, and drug resistance. Numerous Aurora-targeted inhibitors have been developed and are being assessed in preclinical and clinical trials, with the goal of improving head and neck squamous cell carcinoma treatment.
Crystallographic Orientation Dependent Ferroelectric Characteristics of (Bi3.3,La0.8)Ti3O12 (BLT) Capacitors (2005)

ABSTRACT The 70 nm thick (Bi3.3,La0.8)Ti3O12 (BLT) thin films were fabricated by deposition multiple spin coating layers and then crystallized by RTA and FA on Pt/TiOx/SiO2/Si substrate. Films were synthesized by MOD (metal organic decomposition) derived precursor to easy mass production. The randomly oriented BLT thin films have resulted from newly developed noble bake process, while a highly c-axis preferred orientation occurs for conventional baked thin film. The texture coefficient of I(004), I(117), I(111) and I(200) of noble baked BLT capacitors has 0, 0.24, 1.35 and 1.92, respectively. The films were very dense with no apparent pore site. The switching polarization (P*-P∧) and coercive voltage (2 Vc) of randomly oriented BLT thin films were nearly saturated at 3 V to have 20.03 μ C/cm2 and 1.38 V, respectively. However, strongly c-axis oriented thin films have 10.1 μ C/cm2 and 1.42 V for drive 3 V. The random orientation BLT shows good insulating behavior (9.4E-7 A/cm2 at 3 V). Both randomly oriented capacitor and highly c-axis preferred orientation thin films show no degradation of polarization due to fatigue after 1E11 cycles using 3 V (428.5 kV/cm) bipolar square pulse at 1 MHz.
Electron transfer reactions of trifluoroacetylated horse heart cytochrome c (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron transfer reactions of trifluoroacetylated horse heart cytochrome cRobert A. Holwerda, Rita A. Read, Robert A. Scott, Scot Wherland, Harry B. Gray, and Francis MillettCite this: J. Am. Chem. Soc. 1978, 100, 16, 5028–5033Publication Date (Print):August 1, 1978Publication History Published online1 May 2002Published inissue 1 August 1978https://pubs.acs.org/doi/10.1021/ja00484a019https://doi.org/10.1021/ja00484a019research-articleACS PublicationsRequest reuse permissionsArticle Views54Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
LiveAction (2013)

Task automation systems promise to increase human productivity by assisting us with our mundane and difficult tasks. These systems often rely on people to (1) identify the tasks they want automated and (2) specify the procedural steps necessary to accomplish those tasks (i.e., to create task models). However, our interviews with users of a Web task automation system reveal that people find it difficult to identify tasks to automate and most do not even believe they perform repetitive tasks worthy of automation. Furthermore, even when automatable tasks are identified, the well-recognized difficulties of specifying task steps often prevent people from taking advantage of these automation systems. In this research, we analyze real Web usage data and find that people do in fact repeat behaviors on the Web and that automating these behaviors, regardless of their complexity, would reduce the overall number of actions people need to perform when completing their tasks, potentially saving time. Motivated by these findings, we developed LiveAction, a fully-automated approach to generating task models from Web usage data. LiveAction models can be used to populate the task model repositories required by many automation systems, helping us take advantage of automation in our everyday lives.
Performance of a pilot-scale water hyacinth-based secondary treatment system (1989)

Etude de l'elimination de polluants et de la production de biomasse dans un systeme pilote de traitement secondaire d'eaux usees utilisant un macrophyte vegetal de type jacinthe d'eau (Eichornia crassipes)
Spontaneous Hepatic Hemorrhage (1988)

The clinical records and radiologic findings in six patients with spontaneous (nontraumatic) intrahepatic and subcapsular hemorrhage were reviewed. Four patients had underlying liver lesions (hepatocellular carcinoma and metastasis from B-cell lymphoma in one patient each and hepatic adenoma in two other patients). One patient had intrahepatic hemorrhage associated with hepatic necrosis secondary to organophosphate toxicity. The specific etiology of hemorrhage in the remaining patient proved elusive despite an exhaustive search. Hepatic hemorrhage was diagnosed and followed by CT (six cases), sonography (two cases), and celiac arteriography (three cases). Computed tomography was useful in defining the extent of the hematoma and showing density changes related to the age of the hematoma.
Epstein-Barr virus encoded latent membrane protein 1 (LMP1) and TNF receptor associated factors (TRAF): colocalisation of LMP1 and TRAF1 in primary EBV infection and in EBV associated Hodgkin lymphoma (2003)

These results suggest that in non-neoplastic lymphocytes, TRAF1 expression is dependent on the presence of LMP1, and that in IM B cells in vivo, LMP1 associated signalling pathways are active. In HL, TRAF1 is expressed independently of EBV status, probably because of constitutive NF-kappaB activation. The function of TRAF1 in HL remains to be determined.
Microwave Irradiation to Produce High Performance Thermoelectric Material Based on Al Doped ZnO Nanostructures (2020)

Microwave irradiation is found to be effective to provide highly crystalline nanostructured materials. In this work, this technique has been used to produce highly improved thermoelectric (TE) material based on aluminum (Al) doped zinc oxide (ZnO) nanostructures (NSs). The effect of Al dopant at the concentration range 0.5–3 mol % on the structural and TE properties has been investigated in more details. The optimum concentration of Al for better TE performance is found to be 2 mol %, which could significantly increase the electrical conductivity and reduce the thermal conductivity of ZnO NSs and thus enhance the TE performance. This concentration showed almost metallic conductivity behavior for ZnO NSs at low temperatures, e.g., below 500 K. The electrical conductivity reached 400 S/m at room temperature, which is around 200 times greater than the value recorded for the pure ZnO NSs. Remarkably, the measured room temperature thermal conductivity of the microwave synthesized ZnO NSs was very low, which is around 4 W/m·K. This value was further reduced to 0.5 W/m·K by increasing the Al doping to 3 mol %. The figure of merit recorded 0.028 at 675 K, which is 15 times higher than that of the pure ZnO NSs. The output power of a single leg module made of 2 mol % Al doped ZnO NSs was 3.7 µW at 485 K, which is higher by 8 times than that of the pure sample. These results demonstrated the advantage of the microwave irradiation rout as a superior synthetic technique for producing and doping promising TE nanomaterials like ZnO NSs.
Proceedings of the MIT Student Workshop on VLSI and Parallel Systems Held in Dedham, Massachusetts on 21 July 1992 (1992)

Abstract : Partial contents: Micron-Scale Display Technology; Virtual Memory for Data-Parallel Computing; The Optimal Synthesis of VLSI Array Architectures from Algorithmic Descriptions; Clay-1: A Distributed Bit-Parallel Computer; Migration in Distributed-Memory Multiprocessor; Frame Memory Management for the Monsoon Processor; Scan-Based Testability for Fault Tolerant Architectures; Serializing Parallel Programs; A Systems Language Compiler for the J-Machine; The Coprocessor Host Interface Chips.
Preparation and properties of 1,2-bis(triphenylphosphoranyl)benzocyclobutene (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and properties of 1,2-bis(triphenylphosphoranyl)benzocyclobuteneAlfred T. Blomquist and Victor J. HrubyCite this: J. Am. Chem. Soc. 1967, 89, 19, 4996–5007Publication Date (Print):September 1, 1967Publication History Published online1 May 2002Published inissue 1 September 1967https://pubs.acs.org/doi/10.1021/ja00995a030https://doi.org/10.1021/ja00995a030research-articleACS PublicationsRequest reuse permissionsArticle Views225Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
<title>Efficient new superresolution algorithm based on the suppression of ringing artifacts</title> (1998)

A new super resolution algorithm is proposed which can provide bandwidth extension of noisy images in a small number of iterations and is potentially capable of real time operation. Attempts to restore band-limited images frequently introduce ringing artifacts. Methods designed to reduce this ringing often suppress sharp features in the scene. In images with a well-defined background intensity, super resolution techniques involving a positive constraint are effective in suppressing this ringing and providing a high degree of bandwidth extension. Problems arise, however, in a general image where no such well-defined background exists. The first stage of the algorithm reported here addresses these problems by computing an effective background. Features that need to be enhanced then exist as blurred deviations from this background. The background is computed from the first and second differentials of the image with respect to further blurring. It has been possible to suppress ringing artifacts, resulting in bandwidth extension, by comparing the calculated background with the known original blurred image. An iterative procedure based on Gerchberg's error energy reduction technique has produced good results. Computer calculations applied to both synthetic images and real millimeter wave images show that the algorithm is effective, efficient and largely immune to noise.