gebhart/patrepeval huggingface dataset:
24. Longitudinal Assessment of Immune Responses to COVID-19 Vaccines in Solid Organ Transplant Recipients (2021)

Abstract Background mRNA vaccines for coronavirus disease 2019 (COVID-19) illicit strong humoral and cellular responses and have high efficacy for preventing and reducing the risk of severe illness from COVID-19. Since solid organ transplant (SOT) recipients were excluded from the phase 3 trials, the efficacy of the COVID-19 vaccine remains unknown. Understanding the serological responses to COVID vaccines among SOT recipients is essential to better understand vaccine protection for this vulnerable population. Methods In this prospective cohort study, a subset of SOT recipients who were part of our center’s larger antibody study were enrolled prior to receipt of two doses of the BNT162b2 (Pfizer, Inc) vaccine for high resolution immunophenotyping. To date, plasma has been collected for 10 participants on the day of their first dose (baseline), day of their second dose, and 28 days post second dose. 23 healthy participants planning to receive either BNT162b2 or mRNA-1273 (ModernaTX, Inc) were also enrolled, providing plasma at the same timepoints. Ultrasensitive single-molecule array (Simoa) assays were used to detect SARS-CoV-2 Spike (S), S1, receptor-binding domain (RBD) and Nucleocapsid (N) IgG antibodies. Results Participant demographics and SOT recipient characteristics are summarized in Table 1. Low titers of anti-N IgG at all timepoints indicate no natural infection with COVID-19 during the study (Fig 1A). There were significantly lower magnitudes for anti-S (p&amp;lt; 0.0001), anti-S1 (p&amp;lt; 0.0001), and anti-RBD (p&amp;lt; 0.0001) IgG titers on the day of dose 2 and day 28 post second dose for SOT recipients compared to healthy controls (Fig 1B,C,D). Using the internally validated threshold of anti-S IgG &amp;gt;1.07 based on pre-pandemic controls, only 50% of the SOT sub-cohort responded to vaccine after series completion (Fig 2). There was a positive trend between months from transplant and anti-S IgG titer (Fig 3). Table 1: Demographics Figure 1: Anti-N, Anti-S, Anti-S1, Anti-RBD and Anti-N Ig G for healthy v. SOT cohort Black error bars denote median and 95% CI. The dotted line on panel B denotes an internally validated cutoff of 1.07; anti-S IgG titers greater than 1.07 denote a positive response. Figure 3: Time from Transplant v. anti-S IgG Titer SOT recipients further out from transplant tend to have a higher anti-S IgG response. The dotted line denotes an internally validated cutoff, with anti-S IgG titers greater than 1.07 indicating a positive response. Conclusion SOT recipients had a significantly decreased humoral response to mRNA COVID-19 vaccines compared to the healthy cohort, with those further out from transplant more likely to respond. Further research is needed to evaluate T-cell responses and clinical efficacy to maximize the SARS-CoV-2 vaccine response among SOT recipients. Disclosures Ann E. Woolley, MD, MPH, COVAX (Consultant) David Walt, PhD, Quanterix Corporation (Board Member, Shareholder)
(S)-.alpha.-Amino-(2,2'-bipyridine)-6-propanoic acid: a versatile amino acid for de novo metalloprotein design (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT(S)-.alpha.-Amino-(2,2'-bipyridine)-6-propanoic acid: a versatile amino acid for de novo metalloprotein designBarbara Imperiali and Stewart L. FisherCite this: J. Am. Chem. Soc. 1991, 113, 22, 8527–8528Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/ja00022a053https://doi.org/10.1021/ja00022a053research-articleACS PublicationsRequest reuse permissionsArticle Views398Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Cross-Point phase change memory with 4F2 cell size driven by low-contact resistivity poly-si diode (2006)

We have fabricated the cross-point phase change memory with a selection diode made of poly-Si. The selection diode was fabricated using a low-thermal-budget process that achieved low contact resistivity, high on-current density of 8 MA/cm2 and low off-current density of 100 A/cm2. The improvement in the properties of poly-Si diode makes the set/reset operation of the cross-point 4F2 cell possible, leading to the size reduction of phase change memory chip.
Study of a Nano-Square Structure with Defects: Monte Carlo Study (2017)

In this paper, we study the defects effect on magnetic properties of a nano-square structure. This system is composed with alternate layers consisting of the spins σ=3/2 and S=1. More precisely, we examine the effect of different physical parameters which are: the coupling exchange interactions, the external magnetic and the crystal fields applied on the studied system. The ground state phase diagrams have been deduced and discussed in different planes involving such different parameters. Also we study the behavior of this nano-structure by using the Monte Carlo simulations. The behavior of the magnetizations is studied as a function of the external magnetic field, the crystal field, the temperature and the exchange coupling interactions. The magnetizations and the hysteresis cycles are presented and discussed for fixed values of these parameters.
Functionality of the STNV translational enhancer domain correlates with affinity for two wheat germ factors (2001)

The satellite tobacco necrosis virus RNA is uncapped and requires a 3' translational enhancer domain (TED) for translation. Both in the wheat germ extract and in tobacco, TED stimulates in cis translation of heterologous, uncapped RNAs. In this study we investigated to what extent translation stimulation by TED depends on binding to wheat germ factors. We show that in vitro TED binds at least seven wheat germ proteins. Translation and crosslinking assays, to which TED or TED derivatives with reduced functionality were included as competitor, showed that TED function correlates with binding to a 28 kDa protein (p28). One particular condition of competition revealed that p28 binding is not obligatory for TED function. Under this condition, a 30 kDa protein (p30) binds to TED. Importantly, affinity of p30 correlates with functionality of TED. These results strongly suggest that TED has the capacity to stimulate translation by recruiting the translational machinery either via binding to p28 or via binding to p30.
Simple and Efficient Instrumentation for the DSZOOM System (2003)

An efficient and robust instrumentation tool (or compiler support) is necessary for an efficient implementation of fine-grain software-based shared memory systems (SW-DSMs). The DSZOOM system, developed by the Uppsala Architecture Research Team (UART) at Uppsala University, is a sequentially consistent SW-DSM originally developed using EEL (Executable Editing Library) a binary modification tool from University of Wisconsin-Madison. In this thesis, we identify several weaknesses of this original approach and present a new and simple tool for assembler instrumentation. This tool can instrument (modify) highly optimized compiler output for the newest UltraSPARC processors. Currently, the focus of the tool is load-, store-, and load-storeinstrumentation. We also present several low-level optimization techniques that significantly improve the performance of the DSZOOM system. One of the presented techniques is a store-buffer register optimization, a latency-hiding mechanism for memory-store operations, that can lower instrumentation overheads for some applications (as much as 45% for LU-cont, running on two nodes with 8 processors each). We also show that by using this new DSZOOM system we execute faster than the old one on all applications in the SPLASH-2 benchmark suite. Improvements range from 1.07 to 2.82 times (average 1.73).
Evaluation of a Gene-Directed Enzyme-Product Therapy (GDEPT) in Human Pancreatic Tumor Cells and Their Use as In Vivo Models for Pancreatic Cancer (2012)

These data qualify the cell lines as part of valuable in vitro and in vivo models for the use in defined preclinical studies for pancreas tumor therapy.
Outfoxed by RBFOX1‐A caution about ascertainment bias (2014)

We report on two patients with intragenic deletions of RBFOX1 and one patient with an intragenic duplication of RBFOX1. These patients, by report, all had autism spectrum disorder and/or developmental delay and had strong family histories of these conditions. We initially hypothesized that RBFOX1 was another susceptibility locus for autism spectrum disorder or developmental delay. However, epidemiological evidence examining large numbers of individuals did not support this hypothesis and the data presented here suggests that RBFOX1 intragenic copy number variants are not pathogenic. This contradicts previous reports that examined smaller numbers of patients and controls. © 2014 Wiley Periodicals, Inc.
Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice (2012)

Tim-1, a type I transmembrane glycoprotein, consists of an IgV domain and a mucin domain. The IgV domain is essential for binding Tim-1 to its ligands, but little is known about the role of the mucin domain, even though genetic association of TIM-1 with atopy/asthma has been linked to the length of mucin domain. We generated a Tim-1-mutant mouse (Tim-1(Δmucin)) in which the mucin domain was deleted genetically. The mutant mice showed a profound defect in IL-10 production from regulatory B cells (Bregs). Associated with the loss of IL-10 production in B cells, older Tim-1(Δmucin) mice developed spontaneous autoimmunity associated with hyperactive T cells, with increased production of IFN-γ and elevated serum levels of Ig and autoantibodies. However, Tim-1(Δmucin) mice did not develop frank systemic autoimmune disease unless they were crossed onto the Fas-mutant lpr mice on a C57BL/6 background. Tim-1(Δmucin)lpr mice developed accelerated and fulminant systemic autoimmunity with accumulation of abnormal double-negative T cells and autoantibodies to a number of lupus-associated autoantigens. Thus, Tim-1 plays a critical role in maintaining suppressive Breg function, and our data also demonstrate an unexpected role of the Tim-1 mucin domain in regulating Breg function and maintaining self-tolerance.
Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma (2020)

Primary open angle glaucoma (POAG) is a leading cause of blindness world-wide. To identify new susceptibility loci, we meta-analyzed GWAS results from 8 independent studies from the United States (3,853 cases and 33,480 controls) and investigated the most significant SNPs in two Australian studies (1,252 cases and 2,592 controls), 3 European studies (875 cases and 4,107 controls) and a Singaporean Chinese study (1,037 cases and 2,543 controls). A meta-analysis of top SNPs identified three novel loci: rs35934224[T] within TXNRD2 (odds ratio (OR) = 0.78, P = 4.05×10−11 encoding a mitochondrial protein required for redox homeostasis; rs7137828[T] within ATXN2 (OR = 1.17, P = 8.73×10−10), and rs2745572[A] upstream of FOXC1 (OR = 1.17, P = 1.76×10−10). Using RT-PCR and immunohistochemistry, we show TXNRD2 and ATXN2 expression in retinal ganglion cells and the optic nerve head. These results identify new pathways underlying POAG susceptibility and suggest novel targets for preventative therapies.
Measurement of CO2 in Water from an Ultraviolet Oxidizer for a Space-Worthy Wastewater Recovery System Using Raman Spectroscopy (2022)

NASA has been developing and testing a water recovery system for over two decades to minimize the amount of water required for long duration human space missions. A key system component is the total organic carbon analyzer (TOCA) that determines if the recovered water is below the toxicology-defined health limit of 5 mg/L TOC and is safe to drink. The TOCA is composed of a liquid phase loop and a gas phase loop. The TOCA employs an oxidizer to convert the organics in the liquid phase to carbon dioxide (CO<sub>2</sub>) and a liquid-gas separator to isolate the CO<sub>2</sub> for measurement in the gas phase by infrared spectroscopy. In an effort to reduce the consumables, mass, volume, and power of the system, we investigated the ability of surface-enhanced Raman spectroscopy (SERS), and Raman spectroscopy to measure 5 mg/L carbon in water. The SERS measurement employed silver colloids to increase sensitivity, while the Raman measurements used multiple mirrors to increase sensitivity. Here, we present SERS measurements of carbonate (CO<sub>3</sub>=) at 3 mg/L carbon and Raman measurements of CO<sub>2</sub> at 9 mg/L carbon in the effluent water of a new oxidizer being developed for a future TOCA. Both SERS and Raman techniques can determine TOC in the liquid phase, eliminating the need for the gas phase loop and associated supplies and replacement components, which could effectively decrease the size and weight of the current TOCA by as much as 50%.
Estimating the position of illuminants in paintings under weak model assumptions: an application to the works of two Baroque masters (2009)

The problems of estimating the position of an illuminant and the direction of illumination in realist paintings have been addressed using algorithms from computer vision. These algorithms fall into two general categories: In model-independent methods (cast-shadow analysis, occluding-contour analysis, ...), one does not need to know or assume the three-dimensional shapes of the objects in the scene. In model-dependent methods (shape-fromshading, full computer graphics synthesis, ...), one does need to know or assume the three-dimensional shapes. We explore the intermediate- or weak-model condition, where the three-dimensional object rendered is so simple one can very confidently assume its three-dimensional shape and, further, that this shape admits an analytic derivation of the appearance model. Specifically, we can assume that floors and walls are flat and that they are horizontal and vertical, respectively. We derived the maximum-likelihood estimator for the two-dimensional spatial location of a point source in an image as a function of the pattern of brightness (or grayscale value) over such a planar surface. We applied our methods to two paintings of the Baroque, paintings for which the question of the illuminant position is of interest to art historians: Georges de la Tour's Christ in the carpenter's studio (1645) and Caravaggio's The calling of St. Matthew (1599-1600). Our analyses show that a single point source (somewhat near to the depicted candle) is a slightly better explanation of the pattern of brightness on the floor in Christ than are two point sources, one in place of each of the figures. The luminance pattern on the rear wall in The calling implies the source is local, a few meters outside the picture frame-not the infinitely distant sun. Both results are consistent with previous rebuttals of the recent art historical claim that these paintings were executed by means of tracing optically projected images. Our method is the first application of such weak-model methods for inferring the location of illuminants in realist paintings and should find use in other questions in the history of art.
Health‐related quality of life in Chinese patients with primary biliary cirrhosis (2007)

Chinese PBC patients have significant impairment of the HRQOL. The anxiety and depression status of patients had important contribution to the HRQOL.
HSP90: A Rising Star on the Horizon of Anticancer Targets (2005)

Over the past decade, heat-shock protein (HSP)90 has begun to draw increasing attention as a novel anticancer target with unique features. As a molecular chaperone, HSP90 promotes the maturation and maintains the stability of a large number of conformationally labile client proteins, most of which are involved in biologic processes that are often deranged within tumor cells, such as signal transduction, cell-cycle progression and apoptosis. As a result, and in contrast to other molecular targeted therapeutics, inhibitors of HSP90 achieve their promising anticancer activity through simultaneous disruption of many oncogenic substrates within cancer cells. This review provides a brief summary of HSP90 biology and its association with cancer. It describes the discovery and development of HSP90 inhibitors as anticancer agents and their current status in the clinic. Finally, it closes with a discussion of the unique challenges confronting the further development of these agents and their prospects for the future.
Feasibility study of minimal prepared hydroflush screening colonoscopy (2015)

Minimally prepared colonoscopy with the intra-procedural hydroflush technique for colorectal screening is feasible. The water exchange technology compensates for the mild stiffness of the scope. This technique might increase patients' compliance for CRC screening.
High power density fuel cell comprising an array of microchannels (2023)

A fuel cell according to one embodiment includes a porous electrolyte support structure defining an array of microchannels, the microchannels including fuel and oxidant microchannels; fuel electrodes formed along some of the microchannels; and oxidant electrodes formed along other of the microchannels. A method of making a fuel cell according to one embodiment includes forming an array of walls defining microchannels therebetween using at least one of molding, stamping, extrusion, injection and electrodeposition; processing the walls to make the walls porous, thereby creating a porous electrolyte support structure; forming anode electrodes along some of the microchannels; and forming cathode electrodes along other of the microchannels. Additional embodiments are also disclosed.
SWIPT Signalling over Frequency-Selective Channels with a Nonlinear Energy Harvester: Non-Zero Mean and Asymmetric Inputs (2019)

Simultaneous Wireless Information and Power Transfer (SWIPT) over a point-to-point frequency-selective Additive White Gaussian Noise (AWGN) channel is studied. Considering an approximation of the nonlinearity of the harvester, a general form of delivered power in terms of system baseband parameters is derived, which demonstrates the dependency of the delivered power on higher order moment of the baseband channel input distribution. The optimization problem of maximizing Rate-Power (RP) region is studied. Assuming that the Channel State Information (CSI) is available at both the receiver and the transmitter, and constraining to non-zero mean Gaussian input distributions, an optimization algorithm for power allocation among different subchannels is studied. As a special case, optimality conditions for zero mean Gaussian inputs are derived. Results obtained from numerical optimization demonstrate the superiority of non-zero mean Gaussian inputs (with asymmetric power allocation in each complex subchannel) in yielding a larger RP region compared to their zero mean and non-zero mean (with symmetric power allocation in each complex subchannel) counterparts. This severely contrasts with SWIPT design under linear energy harvesting, for which circularly symmetric Gaussian inputs are optimal.
Procedimiento de aplicación de sepiolitas básicas como catalizadores en reacciones de condensación de Knoevenagel (1991)

Structures and regulations of vertebrate channels responsible for sustained calcium elevations after hormone stimulation are largely unknown. Therefore, the Drosophila photoreceptor channels, trp and trpl, which are assumed to be involved in calcium influx, serve as model system, trpl expressed in Sf9 cells showed spontaneous activity. Hormonal stimulations of calcium influx (detected by fura-2) and of an outwardly rectifying current were observed in Sf9 cells coinfected with baculoviruses encoding trpl and various heptahelical receptors for histamine, thrombin, and thromboxane A2, all known to cause phospholipase C-beta activation in mammalian cells. Although the identity of the G-proteins and of possible second messengers involved need to be clarified, it is clear that trpl represents a receptor/G-protein regulated cation channel.
The Microbiome of Osteoarthritic Hip and Knee Joints (2023)

Diagnostic Level II . See Instructions for Authors for a complete description of levels of evidence.
Tao, Zen and Heidegger (2011)

Over the past two decades, a number of authors on Heidegger have recognized that his work has a certain affinity with East Asian thinking, notably with Taoism and Zen Buddhism, especially in his later thought. The fact that the Japanese have published seven translations of Being and Time, and that Heidegger is probably the most-studied modern philosopher in Asia, may well reflect this similarity between his own and East Asian thinking. On various occasions, Heidegger himself spoke of this connection. Otto Pöggeler, an eminent commentator on Heidegger's work, writes that Heidegger “gladly acknowledged to visitors the closeness of his thinking to the Taoist tradition and Zen Buddhism” (1987: 49). William Barrett related that when reading one of D. T. Suzuki's books on Buddhist thought, Heidegger said that Suzuki expressed what he himself had always tried to say (1956: xi).
Liver-specific p70 S6 Kinase Depletion Protects against Hepatic Steatosis and Systemic Insulin Resistance (2012)

Obesity-associated hepatic steatosis is a manifestation of selective insulin resistance whereby lipogenesis remains sensitive to insulin but the ability of insulin to suppress glucose production is impaired. We created a mouse model of liver-specific knockdown of p70 S6 kinase (S6K) (L-S6K-KD) by systemic delivery of an adeno-associated virus carrying a shRNA for S6K and examined the effects on steatosis and insulin resistance. High fat diet (HFD) fed L-S6K-KD mice showed improved glucose tolerance and systemic insulin sensitivity compared with controls, with no changes in food intake or body weight. The induction of lipogenic gene expression was attenuated in the L-S6K-KD mice with decreased sterol regulatory element-binding protein (SREBP)-1c expression and mature SREBP-1c protein, as well as decreased steatosis on HFD. Our results demonstrate the importance of S6K: 1) as a modulator of the hepatic response to fasting/refeeding, 2) in the development of steatosis, and 3) as a key node in selective hepatic insulin resistance in obese mice.
Smart societies (2013)

Social media has become globally ubiquitous, transforming how people are networked and mobilized. This forum explores research and applications of these new networked publics at individual, organizational, and societal levels. Shelly Farnham, Editor