gebhart/patrepeval huggingface dataset:
Supplementary Tables from Clinical and Antitumor Immune Responses in Relapsed/Refractory Follicular Lymphoma Patients after Intranodal Injections of IFNα-Dendritic Cells and Rituximab: a Phase I Clinical Trial (2023)

&lt;p&gt;Supplementary Table I: IFN-DC release criteria and median values registered among patient-derived IFN-DC (min-max range); Supplementary Table 2: Patients MHC-I and MHC-II alleles and IGHV epitope sequences&lt;/p&gt;
Investigation of morphology formation in SBS block copolymer/homopolystyrene blends (2004)

Abstract Polymer blends comprising a polystyrene‐ block ‐polybutadiene‐ block ‐polystyrene (SBS) block copolymer and atactic homopolystyrene (hPS) were investigated using injection molded and solution cast samples. The morphology of the materials was studied by means of transmission electron microscopy (TEM) and scanning force microscopy (SFM). Dynamic mechanical analysis (DMA) was used to characterize the phase behavior and the morphology formation of the block copolymer as well as of the SBS/hPS blends. The glass transition temperatures seem to strongly depend on the homogeneity of the corresponding phases. A distinct difference was found between the morphologies of the blends prepared by different methods. While the SBS block copolymer always shows a lamellar morphology in injection molded or as‐cast samples, the injection molded blends show a disturbance in the morphology consisting of alternating layers. In contrast, in the case of as‐cast samples, added hPS forms polystyrene domains dispersed in a matrix of the pure block copolymer. Regarding the change in the glass transition temperature, in the effective volume and in the interfacial volume obtained from DMA curves, the morphology formation of the injection molded samples (pure SBS block copolymer and the corresponding blends) was investigated. Two different structural models for the blends are proposed. Polym. Eng. Sci. 44:1534–1542, 2004. © 2004 Society of Plastics Engineers.
Suppression of rho B expression in invasive carcinoma from head and neck cancer patients. (2002)

These results give additional support to the notion that RhoB may play a tumor suppressive role in squamous cell carcinomas of the head and neck. The lack of RhoB expression in deeply invasive carcinoma argues against inhibition of RhoB farnesylation as a mediator of farnesyltransferase inhibitors' antitumor activity.
Nanoformulated Remdesivir with Extremely Low Content of Poly(2-oxazoline)-Based Stabilizer for Aerosol Treatment of COVID-19 (2023)

The rise of the novel virus SARS-CoV2 which causes the disease known as COVID-19 has led to a global pandemic claiming millions of lives. With no clinically approved treatment for COVID-19, physicians initially struggled to treat the disease, and a need remains for improved antiviral therapies in this area. It is conceived early in the pandemic that an inhalable formulation of the drug remdesivir which directly targets the virus at the site of infection could improve therapeutic outcomes in COVID-19. A set of requirements are developed that would be conducive to rapid drug approval: 1) try to use GRAS reagents 2) minimize excipient concentration and 3) achieve a working concentration of 5 mg/mL remdesivir to obtain a deliverable dose which is 5-10% of the IV dose. In this work, it is discovered that Poly(2-oxazoline) block copolymers can stabilize drug nanocrystal suspensions and provide suitable formulation characteristics for aerosol delivery while maintaining antiviral efficacy. The authors believe POx block copolymers can be used as a semi-ubiquitous stabilizer for the rapid development of nanocrystal formulations for new and existing diseases.
Four Generations of Technology for Production of Synthetic Liquid Fuel Bbased on Fischer – Tropsch Synthesis. Historical Overvie (2015)

The paper provides an overview of the development of technology for production of synthetic liquid fuels based on the Fischer – Tropsch process. Special attention is paid to recent trends in the technological development. We give general information about the technology of producing synthetic fuels, including process chemistry, typical instrumental solutions, the problem of raw materials, information about catalysts. It is shown that modern industrial technologies based on the Fischer – Tropsch synthesis (XTL) differ significantly from those used in the 1st generation of the process in the 30–40 years of the last century. The most acute problems of the current, third, generation of technology are high specific capital investments and a too wide range of by-products. Technologies of a new, 4th, generation are in transition from pilot to commercial realization. The purpose of development of the 4th generation of XTL is to develop a technology that would open new industrial applications due to simplicity, compactness, and a radical reduction of specific investment and operating costs.
Alkoxymethyl-Substituted 18-Crown-6 and 21-Crown-7 Ligands: Synthesis, Complexation Properties, and Metal Ion Membrane Separations (1995)

Abstract Three novel alkoxymethyl-substituted 18-crown-6 (8–10) and one new alkoxymethyl-substituted 21-crown-7 (11) ligands have been prepared. First, 1-O-tritylpropanetriol (1) and penta- or hexaethylene glycol ditosylate were cyclized in the presence of an alkali metal hydride. The resulting trityloxymethyl-substituted crowns were deprotected to give the hydroxymethyl-substituted 18-crown-6 (6) and hydroxymethyl-substituted 21-crown-7 (7). The latter compounds were alkylated using sodium hydride and the appropriate l-bromoalkane to form 8–11. Complexation properties of these new ligands with the alkali metal cations were studied by a calorimetric titration technique. Compared with the parent 18-crown-6 and 21-crown-7 ligands, the substituted 18-crown-6 ligands demonstrate superior selectivity for K+, while the substituted 21-crown-7 ligand demonstrated less selectivity for Cs+ over other alkali cations. Solvent extraction and membrane separation experiments using these new ligands were also carried out. The results demonstrated that the structural features of these new ligands have a significant influence on cation complexation selectivity and separations potential.
Fabrication of Metallic Nanomesh: Pt Nano-Mesh as a Proof of Concept for Stretchable and Transparent Electrodes (2013)

Two-dimensional ordered arrays of honeycomb morphology of platinum are fabricated by using anodized aluminum oxide template and metal sputtering methods. The resulting metal films are highly conductible (71 Ω/sq), stretchable (16.8%), and transparent (75.2% at 550 nm). The presented synthetic strategy is scalable to large area without noticeable defects by incorporating the deposition of a thin layer of silver. In addition, both the pore size and wall thickness of platinum nanomesh films are straightforwardly controlled with sputtering time. As a proof of concept, the metal nanomesh films using AAO template suggest a new concept of synthesizing transparent and stretchable metal electrodes for future electronic devices.
Aero Engine Concepts Beyond 2030: Part 1 — The Steam Injecting and Recovering Aero Engine (2020)

Abstract Recognizing the attention currently devoted to the environmental impact of aviation, this three-part publication series introduces two new aircraft propulsion concepts for the timeframe beyond 2030. This first part focuses on the steam injecting and recovering aero engine concept. In the second part, the free-piston Composite cycle engine concept is presented. A third publication, building upon those two concepts, presents the project which aims for demonstrating the proof of concept with numerical simulation and test-bench experiments up to a technology readiness level of three. In the steam injecting and recovering aero engine concept, exhaust heat generated steam is injected into the combustion chamber. The humidified mass flow contains significantly more extractable energy than air. Furthermore, the pumping of liquid water up to the necessary pressure requires a magnitude less power than the compression of air, which reduces the internal power demand. Both lead to a noticeable increase in specific power compared to a conventional gas turbine and, foremost, to a significant increase in thermodynamic efficiency. By use of a condenser, installed behind the steam generator, the water is recovered from the exhaust gas-steam mixture. The proposed concept is expected to reduce fuel burn and CO2 emissions by about 15 % and NOx formation can be almost completely avoided compared to state-of-the-art engines of the same technology level. Moreover, the described concept has the potential to drastically reduce or even avoid the formation of condensation trails. Thus, the steam injecting and recovering aero engine concept operated with sustainable aviation fuels offers the potential for climate-neutral aviation. Based on consistent thermodynamic descriptions, preliminary designs and initial performance studies, the potentials of the concepts are analyzed. Complementarily, a detailed discussion on concrete engineering solutions considers the implementation into aircraft. Finally, the impact on emissions is outlined.
Aging Behavior of Ultrafine-Grained Al&ndash;Mg&ndash;Si&ndash;X (X = Cu, Ag, Pt, Pd) Alloys Produced by High-Pressure Torsion (2014)

Age-hardenable Al–Mg–Si alloys containing additional elements of Ag, Cu, Pt or Pd were processed by high-pressure torsion (HPT) and they were subsequently aged at a temperature of 373 K for up to a total period of 5,400 ks. It was found that, in all alloys, the grain sizes after HPT were refined to 300–430 nm and there were significant increases in the hardness through the HPT processing. The hardness was further increased by the subsequent aging treatment, confirming the simultaneous strengthening by grain refinement and fine precipitation. However, the aging behavior was different depending on the alloying elements. In the Cu-added excess Mg alloy, the hardness increase was large and the higher hardness retained for longer aging time when compared with those of non-added alloys. It was suggested that the precipitation of a few particles within a single grain with the size of a few hundred nanometer contributes to appreciable age hardening.
2007 annual research and education meeting of the Spondyloarthritis Research and Therapy Network (SPARTAN). (2008)

The Spondyloarthritis Research and Therapy Network (SPARTAN; www.spartangroup.org) was founded in 2003 by a group of North American clinicians and researchers to promote research, education, and treatment of spondyloarthritis (SpA). In past years, it has produced and disseminated United States-specific modifications of the ASsessments in Ankylosing Spondylitis (ASAS) guidelines for the use of anti-tumor necrosis factor (TNF) therapy in AS1,2. SPARTAN held its fifth annual research meeting in September 2007 in Cleveland, Ohio. Highlights of the meeting included updates on current research in SpA, including epidemiology and genetics, bone formation and inflammation, biomarkers, activation of the IL-23/IL-17 axis, and animal models. A presentation was made on basic and clinical science of inflammatory bowel disease, and an educational pre-meeting conference was specifically designed for rheumatology fellows.
A Powerful Tool to Better Understand Cement Hydration (2017)

The proposed ICP-OES method allows the simultaneous, very accurate determination of high-(Ca, K, Na, S) and low-concentration (Al, Fe, Mg, Si) elements of the pore solutions from cement pastes, with and without superplasticizers.
DURIP 98-99 Visible/Near-IR Optical Parametric Oscillator System for Kinetic Studies of Nonequilibrium Air Plasma (1999)

Abstract : The DURIP grant funds of $122,000 were used in conjunction with $14,103 of institutional non-federal cost-sharing funds to purchase a Continuum Optical Parametric Oscillator (OPO) system. This system comprises a Powerlite 8000 Nd:Yag laser system, a DS-1 temperature stabilized second and third harmonic generator and output, a SL-500 injection seeder, and a Sunlite2 visible OPO/Amplifier. In addition, funds from separate sources in the amount of $26,016.98 were used to purchase a FX-1 frequency doubler in order to extend the system's capabilities to the ultraviolet spectral range. The OPO system was ordered on March 25, 1999 and delivered to Stanford University on August 30, 1999. The complete system is paid in full and all funds from the present DURIP grant have been expended.
Release from masking through spatial separation in distance in hearing impaired listeners (2013)

It is widely accepted that speech intelligibility improves as a speech signal and interfering masker are separated spatially in azimuth. In a previous study [Westermann et al. IHCON (2012)] a similarly strong improvement was found for normal hearing (NH) listeners when target and masker are separated in distance. In this study speech reception thresholds (SRTs) were measured for 16 hearing impaired (HI) listeners using the Listening in Spatialized Noise-Sentences Test (LiSN-S) and the Coordinate Response Measure (CRM). Acoustic scenarios were auralized via headphones using binaural room impulse responses recorded in an auditorium. In the first scenario, the target was presented at a distance of 0.5 m from the center of the listener’s head and the interferer at a distance of 0.5 m or 10 m. In a second setup, the interferer’s location was fixed and the target’s location was varied. HI listeners showed a substantial release from masking as target and interferer were separated in distance. This effect was consistent for both LiSN-S and CRM, but less pronounced than for NH listeners. This study suggests that distance related cues play a significant role when listening in complex environments and are also to some extent available to HI listeners.
Feasibility of in vivo myelin water imaging using 3D multigradient‐echo pulse sequences (2011)

Quantitative myelin water imaging is able to show demyelinating processes and, therefore, provides insight into the pathology of white matter diseases such as multiple sclerosis. So far, mapping of the myelin water fraction most often was performed using single-slice multiecho spin-echo sequences. Recently, a different approach using two-dimensional multigradient-echo pulse sequences was suggested. In this work, a solution to three-dimensional in vivo myelin water fraction imaging is presented that applies multigradient-echo pulse sequences and uses non-negative least squares algorithms to analyze the multicomponent T*(2) decay. The suggested method offers not only whole brain coverage but also clinically practicable acquisition times. The obtained myelin water fraction values are low (6.9% for white matter) but are able to detect demyelination in multiple sclerosis lesions. However, the clinical application of the proposed method remains questionable, because further measurements that clarify the possibility of detecting ongoing processes in lesions are needed.
Synthesis of Cyclosporine. I. Synthesis of enantiomerically pure (2S,3R,4R,6E)‐3‐hydroxy ‐4‐methyl‐2‐methylamino‐6‐octenoic acid starting from tartaric acid (1983)

Abstract Starting from R , R ‐(+)‐tartaric acid, the synthesis of (2 S ,3 R ,4 R 6 E )‐3‐hydroxy ‐4‐methyl‐2‐methylamino‐6‐octenoic acid in 24 steps is reported. This novel amino acid is found in the cyclic undecapeptide cyclosporin A, isolated from the fungal strain Tolypocladium inflatum GAMS . Its stereospecific synthesis allowed, for the first time, the isolation and characterization of the new amino acid previously reported as the ‘C‐9‐amino acid’ [1].
Hybrid Prepreg Conventional Build-Up Laminate for 112Gbit/s SerDes (2019)

High speed SerDes standards demand higher speed signals for the next generation - 112Gbit/sec. The integrity of signals is affected strongly by the physical characteristics of the printed circuit substrate in a 112Gbit/s high speed device. The effect on circuit performance is primarily shown as insertion loss. Insertion loss mainly consists of conductor loss and dielectric loss. In a build-up laminate substrate using stripline structures for high speed signals, parameters which can be varied to affect the insertion loss are dielectric properties, geometry, and Cu surface finish. Both conductor and dielectric loss benefit from coarse geometry. Coarse geometry for high speed conflicts with microelectronics trends for small size and high density. High speed laminate circuit design will require high wiring layer counts to enable necessary signals. In this development, we designed, fabricated, and evaluated a flip chip laminate assembly using both low loss 33um particle filled and 65um low loss glass cloth reinforced dielectric. The latest generation low loss materials of both types were used. Cu surface roughness in the particle filled layers was 250nm Ra while the glass cloth reinforced (prepreg) layer Cu roughness was 200nm Ra. The configuration was a 65mm square PFCBGA(Plastic Flip Chip Ball Grid Array) laminate cross section consisting of four particle filled dielectric layers, four glass reinforced dielectric layers, two conventional core layers, four glass reinforces dielectric layers, four particle filled dielectric layers. The chip was approximately 25x25mm fully populated with flip chip bump at 150um pitch fabricated in 14 nm technology. Impedance and insertion loss characterization coupons were fabricated in all signal layers. Coupons were placed at controlled angle relative to glass cloth direction to enable evaluation of differential pair skew. In addition to high speed signal characterization, the reliability of high speed signal structures and mixed dielectric via stacks were evaluated. Results indicate a feasible path to 112Gbit/sec HSS SerDes in a manufacturable highly complex (cost) configuration. Currently, the target speed is going to 116Gbit/sec.
Predictors of clozapine discontinuation in patients with schizophrenia (2011)

Clozapine has superior efficacy for treating patients with schizophrenia. Its discontinuation could have detrimental consequences. We attempted to identify the clinical parameters that could predict clozapine discontinuation in patients diagnosed as having schizophrenia by conducting a retrospective analysis of all of those who started on clozapine treatment during their hospitalization in our institution between 2002 and 2008 (n=100). Demographic and clinical parameters were analyzed and compared between the 58 patients who continued and the 42 who discontinued clozapine treatment during a follow-up period of 8.1 years. Twenty of the latter patients (47.6%) discontinued clozapine because of nonadherence and 11 (26.2%) because of side effects. Thirty-three of them (78.6%) stopped taking clozapine during the first year of treatment. The duration of clozapine use correlated significantly with the time to readmission (P<0.001). The decrease in number of suicide attempts was higher in those who continued clozapine treatment compared with those who discontinued it (P=0.02). Predictors for drug discontinuation were old age at clozapine initiation and comorbid substance abuse. These findings indicate that patients with schizophrenia with those risk factors need special incentives to be compliant during the first year of clozapine treatment to minimize the negative sequelae of clozapine discontinuation.
Transfer Learning Based Co-surrogate Assisted Evolutionary Bi-objective Optimization for Objectives with Non-uniform Evaluation Times (2021)

Most existing multiobjetive evolutionary algorithms (MOEAs) implicitly assume that each objective function can be evaluated within the same period of time. Typically. this is untenable in many real-world optimization scenarios where evaluation of different objectives involves different computer simulations or physical experiments with distinct time complexity. To address this issue, a transfer learning scheme based on surrogate-assisted evolutionary algorithms (SAEAs) is proposed, in which a co-surrogate is adopted to model the functional relationship between the fast and slow objective functions and a transferable instance selection method is introduced to acquire useful knowledge from the search process of the fast objective. Our experimental results on DTLZ and UF test suites demonstrate that the proposed algorithm is competitive for solving bi-objective optimization where objectives have non-uniform evaluation times.
Influence of TASP‐V, a novel neuropeptide Y (NPY) Y2 agonist, on nasal and bronchial responses evoked by histamine in anaesthetized pigs and in humans (1999)

1. In nine anaesthetized pigs we have studied the influence of intranasal or intrabronchial pretreatment with TASP-V, a neuropeptide Y (NPY) Y2 agonist formed by the attachment of NPY 21-36 to a template-assembled synthetic peptide (TASP), on the functional responses to subsequent intranasal or intrabronchial histamine challenge. 2. In a parallel study, subjective and objective nasal airway resistance (NAR) increase following intranasal histamine challenge was evaluated in 11 healthy volunteers after TASP-V or placebo pretreatment. 3. In pigs, increase in sphenopalatine blood flow induced by histamine dihydrochloride nasal spray (0.25 mg kg(-1) in 3 ml of saline) was significantly reduced by 65% (P<0.05) following intranasal pretreatment with 10 microg kg(-1) of TASP-V. Bronchoconstriction induced by histamine dihydrochloride nebulization (0.5 mg kg(-1) in 3 ml of saline) was significantly attenuated by 25 and 55% following aerosolized pretreatment with TASP-V analogue at 10 and 20 microg kg(-1), respectively. 4. In healthy volunteers, objective increase in NAR and reduction in nasal minimal cross section area (MCSA) induced by intranasal spray of histamine dihydrochloride (15 microg kg(-1) in 200 microl of saline) were significantly attenuated by 50% following local pretreatment with 1.275 microg kg(-1) of TASP-V when compared with saline. 5. It is concluded that intranasal or intrabronchial pretreatment with TASP-V reduced nasal obstruction and bronchoconstriction evoked by histamine challenge in the pig. In healthy human volunteers, this agent attenuated NAR increase and MCSA reduction induced by intranasal application of histamine.
Highly compressed nano-layers in epitaxial silicon carbide membranes for MEMs sensors (2014)

Through a novel methodology for evaluating layer-by-layer residual stresses in epitaxial silicon carbide films with resolution down to 10 nm, we indicate the existence of a highly compressed interfacial nano-layer between the films and their silicon substrates. This layer is consistently present underneath all types of silicon carbide films examined herein, regardless of the extent of residual tensile stress measured in the full thickness of the films, which varies from 300 MPa up to 1300 MPa. We link this nano-layer to the carbonisation step of the film growth process and we discuss in detail the implications in terms of fracture behaviour by bulge testing of micro-machined membranes.