gebhart/patrepeval huggingface dataset:
Myc mediates cancer stem-like cells and EMT changes in triple negative breast cancers cells (2017)

Women with triple negative breast cancer (TNBC) have poor prognosis compared to other breast cancer subtypes. There were several reports indicating racial disparity in breast cancer outcomes between African American (AA) and European American (EA) women. For example, the mortality rates of AA breast cancer patients were three times higher than of EA patients, even though, the incidence is lower in AA women. Our in vitro studies indicate that cancer stem-like cells (CSCs) derived from AA TNBC cell lines have significantly higher self-renewal potential (mammosphere formation) than CSCs derived from EA cell lines. TNBC tumors express high levels of Myc compared to luminal A or HER2 expressing breast cancers. We studied the effects of c-Myc overexpression on CSCs and chemotherapy in AA, and EA derived TNBC cell line(s). Overexpression of c-Myc in AA derived MDA-MB-468 (Myc/MDA-468) cells resulted in a significant increase in CSCs and with minimal changes in epithelial-to-mesenchymal transition (EMT) compared to the control group. In contrast, overexpression of c-Myc in EA derived MDA-MB-231(Myc/MDA-231) cells led to increased epithelial-to-mesenchymal transition (EMT), with a minimal increase in CSCs compared to the control group. Myc/MDA-468 cells were resistant to standard chemotherapeutic treatments such as iniparib (PARP inhibitor) plus cisplatin, / iniparib, cisplatin, paclitaxel and docetaxel. However, Myc/MDA-231 cells, which showed EMT changes responded to iniparib with cisplatin, but were resistant to other drugs, such as iniparib, cisplatin, paclitaxel and docetaxel. Collectively, our results indicate that intrinsic differences in the tumor biology may contribute to the breast cancer disparities.
High-contrast, low-voltage variable reflector for unpolarized light (2017)

GRAPHICAL ABSTRACTHigh-contrast, low-voltage variable reflector for unpolarized lightAll authorsS. V. Serak, S. R. Nersisyan, N. V. Tabiryan, D. M. Steeves, B. R. Kimball, T. J. White & T. J. Bunninghttps://doi.org/10.1080/15421406.2017.1403817Published online:18 January 2018
Synthesis and Characterization of a High-Temperature Thermoset Network Derived from a Multicyclic Cage Compound Functionalized with Exocyclic Allylidene Groups (2019)

A heptacyclo[6.6.0.02,6.03,13.04,11.05,9.010,14]tetradecane (HCTD) complex with terminal allylidene groups at the 7- and 12-positions (HCTD-7,12-diallylidene, 2) was generated at the multigram scale from norbornadiene via an efficient six-step synthesis. Thermal polymerization of 2 at temperatures ranging from 160 to 240 °C yielded a robust cross-linked material with thermal stability up to 488 °C in air, a glass transition temperature of 377 °C, and a char yield (600 °C) of 56% in air. This degree of thermal stability is remarkable for a nonaromatic hydrocarbon polymer and is likely due to the rigid multicyclic cages that make up the bulk of the material. To elucidate the polymerization mechanism, a model compound, 7-allylidenenorbornane (4), was synthesized and thermally cured. This resulted in the formation of polymeric material, suggesting that the cross-linking reaction of 2 proceeds via a free-radical reaction and not through Diels–Alder cycloaddition. Addition of dibutylhydroxytoluene (BHT) to compound 2 delayed the onset of cure, providing further support for a radical mechanism. On the basis of these results, it can be concluded that exocyclic allylidene groups represent a new class of thermosetting end-cap capable of generating highly cross-linked materials with thermal stabilities that rival those of high temperature polyimides. Applications include heat resistant composites utilized in the aerospace, electronic, automotive, and textile industries.
A fast transient response technique for DPWM DC-DC converters (2010)

The demand for adaptive and smart power distributing is becoming very popular in the commercial power line such as a smart grid. The information from the load condition is very important for the distributing. To obtain such information from the multiple-load, the digital control for switching mode power supply (SMPS) is effective. Usually, the digital controller is consisted of DSPs or microprocessors performing with software. But, such as for point of load (POL), adapting digital controller isn't still popular because of its cost or response characteristics even if the controllers are constructed by FPGA or custom LSI which is hardware-logic base. This paper will discuss about the proposed hardware logic type digital controller for POL, which is very simple and unique design. And, accuracy improved output voltage detection method for the proposed digital controller is proposed. The some experiments are done. And the results show the validity of the proposed circuits.
Torque Modeling and Control of a Variable Compression Engine (2003)

The SAAB variable compression engine is a new engine concept that enables the fuel consumption to be radically cut by varying the compression ratio. A challenge with this new engine concept is that the compression ratio has a direct influence on the output torque, which means that a change in compression ratio also leads to a change in the torque. A torque change may be felt as a jerk in the movement of the car, and this is an undesirable effect since the driver has no control over the compression ratio. The aim of this master's thesis work is to develop a torque control strategy for the SAAB variable compression engine. Where the main control objective is to make the output torque behave in a desirable way despite the influence of compression ratio changes. The controller is developed using a design method called Internal Model Control, which is a straightforward way of both configuring a controller and determining its parameters. The controller has been implemented and evaluated in a real engine, and has proved to be able to reduce the effect of compression ratio disturbance.
Lenvatinib Plus Pembrolizumab for Advanced Endometrial Cancer (2022)

(Abstracted from N Engl J Med 2022;386:437–448) Little consensus exists on optimal treatment for advanced or recurrent endometrial cancer after disease progression with platinum-based chemotherapy. Lenvatinib is a multitargeted tyrosine kinase inhibitor that as a single agent has demonstrated limited efficacy as second-line treatment of recurrent endometrial carcinoma.
The effect of air pollution and weather on lung function in exercising children and adolescents. (1974)

Lung functions in children and adolescents were tested under conditions of exercise with exposures to pollution and high temperatures. Variables, such as time of day, smoking, and respiratory medical history, were controlled in the analysis. Exercise alone, in the absence of air pollution and high temperatures, did not influence lung function. Exposures to pollutants of either oxidant or reducing type and to high temperatures produced postexercise decreases in forced vital capacity and 1-second forced expiratory volume in children and adolescents. The decreases were related to the relative levels of pollution and temperature. Longitudinal studies and possibly controlled exposure experiments are needed to confirm and quantify the relationships found in this study.
Design, Implementation, and Performance of a Load Balancer for SIP Server Clusters (2012)

This paper introduces several novel load-balancing algorithms for distributing Session Initiation Protocol (SIP) requests to a cluster of SIP servers. Our load balancer improves both throughput and response time versus a single node while exposing a single interface to external clients. We present the design, implementation, and evaluation of our system using a cluster of Intel x86 machines running Linux. We compare our algorithms to several well-known approaches and present scalability results for up to 10 nodes. Our best algorithm, Transaction Least-Work-Left (TLWL), achieves its performance by integrating several features: knowledge of the SIP protocol, dynamic estimates of back-end server load, distinguishing transactions from calls, recognizing variability in call length, and exploiting differences in processing costs for different SIP transactions. By combining these features, our algorithm provides finer-grained load balancing than standard approaches, resulting in throughput improvements of up to 24% and response-time improvements of up to two orders of magnitude. We present a detailed analysis of occupancy to show how our algorithms significantly reduce response time.
Neuro-fuzzy model tree approach to virtual sensing of transient diesel soot and NOx emissions (2014)

Diesel engine combustion and emission formation are highly nonlinear and thus create a challenge related to engine diagnostics and engine control with emission feedback. This article describes the development of neuro-fuzzy models for prediction of transient NO X and soot emission from a diesel engine. The modeling techniques are motivated by the idea of divide and conquer the input–output space. The complex problem is divided into multiple simpler subproblems, which are then identified using simpler class of models. This article explores two different choices of local models, specifically polynomial and neural networks. The modeling technique is augmented with input relevance algorithm to select the most relevant input regressors. Two algorithms, namely, orthogonal least square and automatic relevance determination, are introduced. The models are data driven, and an advanced experimental setup incorporating a medium duty diesel engine and fast emission analyzers for soot and NO X is used to generate training data. The choice of local models and input relevance algorithm is validated with instantaneous emission recorded during transient schedules different from those used in development. High prediction accuracy, both qualitatively and quantitatively, is demonstrated with low computational cost.
Improved generation of anti-tumor immunity by antigen dose limitation (2007)

These findings demonstrate that the ratio of apoptotic cells supplied to DC is an important determinant of whether CD8 anti-tumor immunity or immunosuppression is generated.
Bacterial infection monitoring in the early period after liver transplantation (2018)

Since the full effect of immunosuppression is not yet present during the first month after LT, we suggest that the number of bacterial culture test could be reduced such that they are performed every other day depending on patient's situation.
054 Baseline characteristics of the Phase III GRADUATE studies: investigating subcu- taneous gantenerumab in early AD (2022)

Gantenerumab is a fully human anti-amyloid beta (Aβ) monoclonal immunoglobulin G1 antibody in devel- opment for the treatment of Alzheimer’s disease (AD). Two ongoing multicentre, randomised, double-blind, placebo-controlled, Phase III studies, GRADUATE I ( NCT03444870 ) and GRADUATE II ( NCT03443973 ), are assessing the efficacy and safety of subcutaneous gantenerumab in early AD for 27 months. Eligible participants had prodromal AD or probable AD dementia; demonstrated abnormal memory using the Free and Cued Selective Recall Test; met criteria for the Mini-Mental State Examination (≥22) and Clinical Dementia Rating – Global Score (0.5-1); and had confirmed Aβ pathology. Participants were randomised 1:1 to receive subcutaneous gantenerumab or placebo, administered at study site or via home nursing. The study drug is titrated in three up-titration steps (120 mg, 225 mg, 510 mg monthly) over 9-months to the target 1,020 mg monthly dosage. All participants receive the same titration and target dose, regardless of apolipoprotein E β4 status. The GRADUATE primary endpoint is change from baseline to Week 116 in Clinical Dementia Rating scale – Sum of Boxes. Secondary efficacy measures, fluid and imaging biomarkers, and safety are also being assessed. Recruitment is complete. Participants were enrolled from 32 countries across 5 continents. Detailed baseline characteristics will be presented.
Morphological and Chemical Tuning of High-Energy-Density Metal Oxides for Lithium Ion Battery Electrode Applications (2017)

We present that metal oxides represent a set of promising materials for use as electrodes within lithium ion batteries, but unfortunately, these tend to suffer from limitations associated with poor ionic and electron conductivity as well as low cycling performance. Hence, to achieve the goal of creating economical, relatively less toxic, thermally stable, and simultaneously high-energy-density electrode materials, we have put forth a number of targeted strategies, aimed at rationally improving upon electrochemical performance. Specifically, in this Perspective, we discuss the precise roles and effects of controllably varying not only (i) morphology but also (ii) chemistry as a means of advancing, ameliorating, and fundamentally tuning the development and evolution of Fe<sub>3</sub>O<sub>4</sub>, Li<sub>4</sub>Ti<sub>5</sub>O<sub>12</sub>, TiO<sub>2</sub>, and LiV<sub>3</sub>O<sub>8</sub> as viable and ubiquitous energy storage materials.
SSDFS: Towards LFS Flash-Friendly File System without GC operation (2019)

Solid state drives have a number of interesting characteristics. However, there are numerous file system and storage design issues for SSDs that impact the performance and device endurance. Many flash-oriented and flash-friendly file systems introduce significant write amplification issue and GC overhead that results in shorter SSD lifetime and necessity to use the NAND flash overprovisioning. SSDFS file system introduces several authentic concepts and mechanisms: logical segment, logical extent, segment's PEBs pool, Main/Diff/Journal areas in the PEB's log, Diff-On-Write approach, PEBs migration scheme, hot/warm data self-migration, segment bitmap, hybrid b-tree, shared dictionary b-tree, shared extents b-tree. Combination of all suggested concepts are able: (1) manage write amplification in smart way, (2) decrease GC overhead, (3) prolong SSD lifetime, and (4) provide predictable file system's performance.
Análise da Gestão da Informação para a Saúde Preventiva: o caso do Projeto Garotada Solidária contra o contágio das DST/AIDS (2015)

Na sociedade contemporânea, a informacao e o conhecimento tornaram-se recursos estrategicos que englobam a transmissao, a valorizacao, o armazenamento, a distribuicao e a disseminacao da informacao como elementos centrais de atividades economicas das organizacoes. Neste panorama emerge a constante preocupacao com a realidade social onde as pessoas estao inseridas, preocupacoes estas que estao voltadas para a exclusao e a inclusao social, onde se observa, cada vez mais, o fortalecimento das organizacoes ligadas ao terceiro setor, mais precisamente as Organizacoes Nao Governamentais (ONGs), que contribuem para o desenvolvimento social. Assim, a gestao da informacao (GI) atua como um elemento estrategico para a execucao de projetos que possuem como elemento central e essencial a informacao. Essa pesquisa foi desenvolvida com objetivo de analisar acoes que compoem o processo de GI e que sao adotadas na implementacao do Projeto Garotada Solidaria (PGS), promovido pela ONG Amazona. Essa organizacao trabalha com a informacao preventiva, por meio da conscientizacao de jovens contra o contagio das DST/AIDS em cinco comunidades, que se encontram em situacao de risco, localizadas no entorno da cidade de Joao Pessoa-PB. O estudo foi elaborado a partir de fundamentos teoricos da Ciencia da Informacao e, para sua efetivacao, foi aplicado o modelo de gestao da informacao proposto por McGee e Prusak (1994). Trata-se de uma pesquisa qualitativa, cujo metodo utilizado foi o estudo de caso, tendo em vista a necessidade de desenvolver um aprofundamento exaustivo visando adquirir um amplo e minucioso conhecimento do objeto da pesquisa. Atraves da coleta e analise dos dados, percebeu-se que o processo de GI e realizado de forma nao planejada, o que reduz o potencial que este poderia ter na consecucao dos objetivos a que se propoe o PGS. Essa fragilidade fez com que em algumas comunidades os resultados fossem insatisfatorios, pois houve a interferencia de diferentes problemas que nao puderam ser sanados a contento, o que acabou por comprometer o exito esperado.
Towards Pathway Variation Identification (2014)

A Care Pathway is a knowledge-centric process to guide clinicians to provide evidence-based care to patients with specific conditions. One existing problem for care pathways is that they often fail to reflect the best clinical practice as a result of not being adequately updated. A better understanding of the gaps between a care pathway and real practice requires aligning patient records with the pathway. Patient records are unlabeled in practice making it difficult to align them with a care pathway which is inherently complex due to its representation as a hierarchical and declarative process model (HDPM). This paper proposes to solve this problem by developing a Hierarchical Markov Random Field (HMRF) method so that a set of patient records can best fit a given care pathway. We validate the effectiveness of the method with experiments on both synthesized data and real clinical data.
X-ray diffraction, magnetic, and transport study of lattice instabilities and metal-insulator transition inCaV1−xTixO3(0⩽x⩽0.4) (2004)

${\mathrm{CaVO}}_{3}$ is metastable in air at room temperature. Measurements below room temperature on fresh, polycrystalline ${\mathrm{CaV}}_{1\ensuremath{-}x}{\mathrm{Ti}}_{x}{\mathrm{O}}_{3}$, $0\ensuremath{\leqslant}x\ensuremath{\leqslant}0.4$ samples that were cold-pressed into dense pellets showed a resistivity $\ensuremath{\rho}(T)={\ensuremath{\rho}}_{0}+a{T}^{3∕2}$ for $x=0$ and 0.05, but a $\ensuremath{\rho}(T)={\ensuremath{\rho}}_{0}+b{T}^{2}$ for $x=0.1$ and a transitional temperature dependence in $x=0.2$ and 0.3 to a $\ensuremath{\rho}(T)\ensuremath{\propto}\mathrm{exp}{({T}_{0}∕T)}^{1∕4}$ for $x=0.4$. The thermoelectric power shows no phonon-drag component in any sample and a systematic transition above $200\phantom{\rule{0.3em}{0ex}}\mathrm{K}$ from a small, temperature-independent behavior in ${\mathrm{CaVO}}_{3}$ to an unusual increase with temperature in the $x=0.3$ and 0.4 samples. A nearly temperature-independent paramagnetism above $150\phantom{\rule{0.3em}{0ex}}\mathrm{K}$ is enhanced relative to a conventional Pauli paramagnetism by two orders of magnitude, and the low-temperature paramagnetism is dominated by localized spins that exhibit a sharp increase in concentration in the range $0.2&lt;x\ensuremath{\leqslant}0.4$. A small step increase of the linear variation of volume with $x$ occurs at $x\ensuremath{\approx}0.1$. The solid-solution range does not extend significantly beyond $x=0.4$. These data are interpreted in terms of a first-order Mott--Hubbard transition manifesting itself as strong-correlation fluctuations in a narrow ${\ensuremath{\pi}}^{*}$ band of the ${\mathrm{VO}}_{3}$ array in ${\mathrm{CaVO}}_{3}$ and an inability to obtain complete solid solution of the ${\mathrm{CaVO}}_{3}--{\mathrm{CaTiO}}_{3}$ system. Substitution of $\mathrm{Ti}(\mathrm{IV})$ introduces Anderson-localized states below a mobility edge ${\ensuremath{\mu}}_{c}$ that increases with $x$, crossing ${\ensuremath{\epsilon}}_{F}$ in the range $0.2&lt;x&lt;0.4$. A trapping out of the strong-correlation fluctuations as localized V(IV): ${t}^{1}{e}^{0}$ configurations is postulated to occur for $x\ensuremath{\geqslant}0.1$.
<title>TOW optical and infrared test and alignment calibration capability</title> (1996)

This paper describes the design of test equipment constructed to enable the Marine Corps Logistics Base the capability to provide the required optical/IR boresight and electronic tests for rebuild and TOSH (TOW optical sight hardening) modification for the TOW (tube launched, optically tracked, wire guided) guided missile launcher optical/infrared sight. Optical modification and calibration are performed to improve system accuracy and reliability against failure, especially in a battlefield environment. Although principle concern was for the day sight, provision for the thermal night sight was also included. This design includes a large diameter optical beam, provision for thermal targets and night sight boresight alignment capability with the day sight. Primarily, a specially constructed collimator test set is discussed, implemented as the TOW 150 test and alignment station. In addition, a precision TOSH prism test system is briefly described, which is used to facilitate internal optical component boresight alignment utilizing a HeNe laser, alignment telescope and video camera. Radiometric theory is applied to the collimator geometry, which includes the modulation factor, Planck radiation function and appropriate bandpass integrated to yield effective rms irradiance values for calibration of the day sight.
Supplementary Figure Legends 1-5 from Skin-Test Infiltrating Lymphocytes Early Predict Clinical Outcome of Dendritic Cell–Based Vaccination in Metastatic Melanoma (2023)

&lt;p&gt;PDF file - 48K&lt;/p&gt;
It Is All in the Claims! [IP Corner] (2015)

When Iâ€™m not pulling together the next issue of IEEE Consumer Electronics Magazine or writing my next column or editorial, I occasionally do â€œrealâ€ work. My day job is at the local university, but I also do some consulting for industry, and, as you might guess, one of the things that industry is willing to pay for is my experience and know-how with regard to patents. It is also interesting the sort of things you get asked to look into.
QLP: a joint buffer management and scheduling scheme for input queued switches (2002)

We propose the queue length proportional (QLP) assignment algorithm for input queued switches that considers buffer management and scheduling mechanism inclusively to obtain an optimal assignment of both bandwidth and buffer space according to the real traffic load. The bandwidth assignment is implemented by considering both bandwidth and backlogged queue lengths, so that it is possible to obtain a high throughput as well as a low cell loss ratio at the same time. QLP is shown to be able to maximize overall throughputs and improve buffer utilization as compared to those which treat buffer management and scheduling as separate functions.
Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool (2017)

Talin, a cytoskeletal protein essential in mediating integrin activation, has been previously shown to be involved in the regulation of T cell proliferation and function. In this study, we describe a role for talin in maintaining the homeostasis and survival of the regulatory T (Treg) cell pool. T cell-specific deletion of talin in <i>Tln1</i><sup>fl/fl</sup><i>Cd4</i><sup>Cre</sup> mice resulted in spontaneous lymphocyte activation, primarily due to numerical and functional deficiencies of Treg cells in the periphery. Peripheral talin-deficient Treg cells were unable to maintain high expression of IL-2Rα, resulting in impaired IL-2 signaling and ultimately leading to increased apoptosis through downregulation of prosurvival proteins Bcl-2 and Mcl-1. The requirement for talin in maintaining high IL-2Rα expression by Treg cells was due, in part, to integrin LFA-1-mediated interactions between Treg cells and dendritic cells. Collectively, our data suggest a critical role for talin in Treg cell-mediated maintenance of immune homeostasis.