gebhart/patrepeval huggingface dataset:
A Universal Systolic Array for Linear MIMO Detections (2008)

The detection of MIMO signals presents a formidable computation challenge due to the inherent complexity incurred by matrix-type wireless fading channels. To reduce the hardware cost, linear MIMO detection algorithms can be used instead of non-linear space-time processing. Conventionally, adaptive linear algorithms such as RLS and LMS are treated separately in implementation from matrix inversion based algorithms such as ZF and MMSE. In this paper, we identify the similarities between the QR-decomposition based forms of RLS and MMSE MIMO detection and present a unified systolic array implementation that can accommodate both. In the meanwhile, some subtle but important differences also exist. As a result, the unified array must have a size of N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</sub> x N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</sub> (assuming N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> les N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</sub> ) and both array inputs and array operations need to be controlled accordingly. As special cases of RLS and MMSE, LMS and ZF can also be realized in the same array, making the array flexible enough for all linear MIMO detection algorithms.
ChemInform Abstract: The Chemistry of Polycyclic Arene Imine. Part 6. 1‐[N,N‐Di(2‐propenyl)‐9‐phenanthreneamine‐10‐yl]‐1a,9b‐dihydrophenanthro[9,10‐b]azirine, an Unusual Allylation Product of Phenanthrene 9,10‐Imine. (1986)

Abstract Aus dem Phenanthren‐ 9,10‐imin (Ia) erhält man die Allylverbindung (Ib), die über das Salz (II) zur im Titel genannten Verbindung (III) führt.
Measurement of acoustic intensity in reverberant sound fields (1983)

The analysis of acoustic intensity measurement in propagating unbounded acoustic fields has been widely investigated in the last five years. There has, however, been very little published on the measurement of acoustic intensity in reverberant environments. It is the object of this talk to present some basic theoretical and experimental results that pertain to the nature of understanding sound energy flow in reverberant and specialized active acoustic fields. Measurements of a source in a reverberation room will be shown for distances of up to four times the critical distance from the source. The effects of bias and random errors in context to reverberant fields will be discussed and related to the experimental results presented.
Improving communication in PGAS environments (2013)

The goal of Partitioned Global Address Space (PGAS) languages is to improve programmer productivity in large scale parallel machines. However, PGAS programs may have many fine-grained shared accesses that lead to performance degradation. Manual code transformations or compiler optimizations are required to improve the performance of programs with fine-grained accesses. The downside of manual code transformations is the increased program complexity that hinders programmer productivity. On the other hand, most compiler optimizations of fine-grain accesses require knowledge of physical data mapping and the use of parallel loop constructs.
Venous haemodynamics after total knee arthroplasty (1998)

We performed a crossover study to evaluate the haemodynamic effect of active dorsal to plantar flexion and seven pneumatic compression devices in ten patients who had a total knee arthroplasty. Using the Acuson 128XP/10 duplex ultrasound unit with a 5MHz linear array probe, we assessed the augmentation of peak venous velocity and venous volume above and below the junction of the greater saphenous and common femoral veins in order to study both the deep and superficial venous systems. The pneumatic compression devices evaluated included two foot pumps (A-V Impulse System and PlexiPulse Foot), a foot-calf pump (PlexiPulse Foot-Calf), a calf pump (VenaFlow System) and three calf-thigh pumps (SCD System, Flowtron DVT and Jobst Athrombic Pump). The devices differed in a number of ways, including the length and location of the sleeve and bladder, the frequency and duration of activation, the rate of pressure rise, and the maximum pressure achieved. A randomisation table was used to determine the order of the test conditions for each patient. The enhancement of peak venous velocity occurred primarily in the deep venous system below the level of the saphenofemoral junction. The increases in peak venous velocity were as follows: active dorsal to plantar flexion 175%; foot pumps, A-V Impulse System 29% and PlexiPulse 65%; foot-calf pump, PlexiPulse, 221%; calf pump, VenaFlow, 302% and calf-thigh pumps, Flowtron DVT 87%, SCD System 116% and Jobst Athrombic Pump 263%. All the devices augmented venous volume, the greatest effect being seen with those incorporating calf compression. The increases in ml/min were found in the deep venous system as follows: foot pumps, A-V Impulse System 9.6 and PlexiPulse Foot 16.7; foot-calf pump, PlexiPulse, 38.1; calf pump, VenaFlow, 26.2; calf-thigh pumps, Flowtron DVT 61.5, SCD System 34.7 and Jobst Athrombic Pump 82.3. Active dorsal to plantar flexion generated 8.5 ml for a single calf contraction.
Improvement of the Light Emission Efficiency on Nonpolar a-plane GaN LEDs with SiO2 Current Blocking Layer (2017)

In this study, we investigate the <TEX>$SiO_2$</TEX> current blocking layer (CBL) to improve light output power efficiency in nonpolar a-plane (11-20) GaN LEDs on a r-plane sapphire substrate. The <TEX>$SiO_2$</TEX> CBL was produced under the p-pad layer using plasma enhanced chemical vapor deposition (PECVD). The results show that nonpolar GaN LED light output power with the <TEX>$SiO_2$</TEX> CBL is considerably enhanced compared without the <TEX>$SiO_2$</TEX> CBL. This can be attributed to reduced light absorption at the p-pad due to current blocking to the active layer by the <TEX>$SiO_2$</TEX> CBL.
Biotin carboxyl carrier protein and carboxyltransferase subunits of the multi-subunit form of acetyl-CoA carboxylase from Brassica napus: cloning and analysis of expression during oilseed rape embryogenesis (1996)

In the oilseed rape Brassica napus there are two forms of acetyl-CoA carboxylase (ACCase). As in other dicotyledonous plants there is a type I ACCase, the single polypeptide 220 kDa form, and a type II multi-subunit complex analogous to that of Escherichia coli and Anabaena. This paper describes the cloning and characterization of a plant biotin carboxyl carrier protein (BCCP) from the type II ACCase complex that shows 61% identity/79% similarity with Anabaena BCCP at the amino acid level. Six classes of nuclear encoded oilseed rape BCCP cDNA were clones, two of which contained the entire coding region. The BCCP sequences allowed the assignment of function to two previously unassigned Arabidopsis expressed sequence tag (EST) sequences. We also report the cloning of a second type II ACCase component from oilseed rape, the beta-carboxyltransferase subunit (betaCT), which is chloroplast-encoded. Northern analysis showed that although the relative levels of BCCP and betaCT mRNA differed between different oilseed rape tissues, their temporal patterns of expression were identical during embryo development. At the protein level, expression of BCCP during embryo development was studied by Western blotting, using affinity-purified anti-biotin polyclonal sera. With this technique a 35 kDa protein thought to be BCCP was shown to reside within the chloroplast. This analysis also permitted us to view the differential expression of several unidentified biotinylated proteins during embryogenesis.
Supplementary Figure Legend from The Checkpoint Kinase Inhibitor AZD7762 Potentiates Chemotherapy-Induced Apoptosis of <i>p53</i>-Mutated Multiple Myeloma Cells (2023)

&lt;p&gt;PDF file, 52KB.&lt;/p&gt;
Outage margin and power constraints in cognitive radio with multiple antennas (2009)

In the commons model for spectrum usage, the cognitive (secondary) users are allowed to use the spectrum as long as the target performance in the primary system is not violated. In this paper we consider primary system that has a target outage performance and the transmission power of the secondary transmitter (STX) should be appropriately not to violate the target outage probability for the primary terminals (PT). We have considered two types of STX, with single antenna (SISO STX) and two antennas (MISO STX) and analyzed the allowed secondary power. In general, the power level allowed for the SISO STX differs from the total power level allowed for the MISO STX. Our analysis shows that the relation between these power levels changes as the direct component (the K-factor) of the Ricean fading in the primary channel changes. For a large K-factor in the primary system, the total power allowed for a MISO STX is higher than the power allowed for a SISO STX system. The situation is reversed when the fading in the primary system has a low value of the K-factor and moves towards Rayleigh fading. This implies that, for example, when the direct component in the primary system is substantial, the usage of multiple antennas in the cognitive system has additional benefit, as it can use a higher power.
Systemic Immunization with an ALVAC-HIV-1/Protein Boost Vaccine Strategy Protects Rhesus Macaques from CD4+T-Cell Loss and Reduces both Systemic and Mucosal Simian-Human Immunodeficiency Virus SHIVKU2RNA Levels (2006)

Transmission of human immunodeficiency virus type 1 (HIV-1) occurs primarily via the mucosal route, suggesting that HIV-1 vaccines may need to elicit mucosal immune responses. Here, we investigated the immunogenicity and relative efficacy of systemic immunization with two human ALVAC-HIV-1 recombinant vaccines expressing Gag, Pol, and gp120 (vCP250) or Gag, Pol, and gp160 (vCP1420) in a prime-boost protocol with their homologous vaccine native Env proteins. The relative efficacy was measured against a high-dose mucosal exposure to the pathogenic neutralization-resistant variant SHIV(KU2) (simian-human immunodeficiency virus). Systemic immunization with both vaccine regimens decreased viral load levels not only in blood but unexpectedly also in mucosal sites and protected macaques from peripheral CD4+ T-cell loss. This protective effect was stronger when the gp120 antigen was included in the vaccine. Inclusion of recombinant Tat protein in the boosting phase along with the Env protein did not contribute further to the preservation of CD4+ T cells. Thus, systemic immunization with ALVAC-HIV-1 vaccine candidates elicits anti-HIV-1 immune responses able to contain virus replication also at mucosal sites in macaques.
4-Acetamidobenzenesulfonyl azide (2006)

The title compound, C 8 H 8 N 4 O 3 S, is planar chiral in the solid state. It crystallizes with three independent molecules in the asymmetric unit, two of which have the same chirality and the third is the opposite enantiomer. Partial inversion twinning is present in the crystal which was examined. All three molecules are connected via hydrogen bonds between the amide groups, forming a helix around the b axis of the unit cell.
Optimization of light emitting diodes based on bipolar double-barrier resonant-tunneling structures (2002)

A bipolar double-barrier resonant-tunneling light emitting diode will have maximum emitted light intensity if (1) electrons and holes simultaneously resonant-tunnel into the quantum well, (2) the charge carriers are entirely trapped in the well as the only light source, and (3) the device operates at nearly zero-field condition. We have performed a theoretical modeling, by solving selfconsistently the Schrodinger equation and the Poisson equation, to optimize such resonant-tunneling light emitting diodes with respect to the geometric structures, the chemical compositions, and the doping profiles. All physical parameters are calculated from first principle, except the electron-hole recombination rate which is treated as an input parameter. We have also optimized the device performance with respect to the temperature stability, such that the profile of the electroluminescence spectrum is insensitive to the temperature. A completely automated computer code has been constructed for such theoretical modeling of light emitting diodes.
Clustered ChIP-Seq-defined transcription factor binding sites and histone modifications map distinct classes of regulatory elements (2011)

By integrating genomewide data of transcription factor binding and chromatin structure and using our data-driven approach, we pinpointed the chromatin marks that best explain transcription factor association with different regulatory elements. Our results also indicate that a modest selection of transcription factors may be sufficient to map most regulatory elements in the human genome.
DrugSniper, a Tool to Exploit Loss-Of-Function Screens, Identifies CREBBP as a Predictive Biomarker of VOLASERTIB in Small Cell Lung Carcinoma (SCLC) (2020)

The development of predictive biomarkers of response to targeted therapies is an unmet clinical need for many antitumoral agents. Recent genome-wide loss-of-function screens, such as RNA interference (RNAi) and CRISPR-Cas9 libraries, are an unprecedented resource to identify novel drug targets, reposition drugs and associate predictive biomarkers in the context of precision oncology. In this work, we have developed and validated a large-scale bioinformatics tool named DrugSniper, which exploits loss-of-function experiments to model the sensitivity of 6237 inhibitors and predict their corresponding biomarkers of sensitivity in 30 tumor types. Applying DrugSniper to small cell lung cancer (SCLC), we identified genes extensively explored in SCLC, such as Aurora kinases or epigenetic agents. Interestingly, the analysis suggested a remarkable vulnerability to polo-like kinase 1 (<i>PLK1</i>) inhibition in <i>CREBBP</i>-mutant SCLC cells. We validated this association in vitro using four mutated and four wild-type SCLC cell lines and two <i>PLK1</i> inhibitors (Volasertib and BI2536), confirming that the effect of <i>PLK1</i> inhibitors depended on the mutational status of <i>CREBBP</i>. Besides, DrugSniper was validated in-silico with several known clinically-used treatments, including the sensitivity of Tyrosine Kinase Inhibitors (TKIs) and Vemurafenib to <i>FLT3</i> and <i>BRAF</i> mutant cells, respectively. These findings show the potential of genome-wide loss-of-function screens to identify new personalized therapeutic hypotheses in SCLC and potentially in other tumors, which is a valuable starting point for further drug development and drug repositioning projects.
Bayesian Quadratic Reinforcement Learning (2009)

The idea of using "optimistic" evaluations to guide exploration has been around for a long time, but has received renewed interest recently thanks to the development of bound-based guarantees [Kolter and Ng, 2009].Asmuth et al. [2009] have recently presented a way to construct optimistic evaluations by merging sampled MDPs.Their BOSS algorithm is polynomial in the size of the state-action-space of the merged MDP, and thus a multiple of the size of the actual state space.
Virginia Master Naturalist Basic Training Course. Ichthyology (2013)

Describes the diversity and distribution of fishes in Virginia and their role in Virginia ecosystems, key characteristics used to identify fish and basic fish taxonomy, the biology and natural history of fishes, threats and issues relating to fish in Virginia, rare of special species that indicate habitat quality, appropriate methods for studying fish, and basic principles of fisheries management.
The deubiquitylase USP9X controls ribosomal stalling (2020)

Abstract When a ribosome stalls during translation, it runs the risk of collision with a trailing ribosome. Such an encounter leads to the formation of a stable di-ribosome complex, which needs to be resolved by a dedicated machinery. The initial stalling and the subsequent resolution of di-ribosomal complexes requires activity of Makorin and ZNF598 ubiquitin E3 ligases respectively, through ubiquitylation of the eS10 and uS10 sub-units of the ribosome. It is common for the stability of RING E3 ligases to be regulated by an interacting deubiquitylase (DUB), which often opposes auto-ubiquitylation of the E3. Here, we show that the DUB USP9X directly interacts with ZNF598 and regulates its abundance through the control of protein stability in human cells. We have developed a highly specific small molecule inhibitor of USP9X. Proteomics analysis, following inhibitor treatment of HCT116 cells, confirms previous reports linking USP9X with centrosome associated protein stability and reveals loss of ZNF598 and Makorin 2. In the absence of USP9X or following chemical inhibition of its catalytic activity, steady state levels of Makorins and ZNF598 are diminished and the ribosomal quality control pathway is impaired.
Determination of the posterior boundary of Wernicke's area based on multimodal connectivity profiles (2015)

Wernicke's area is one of the most important language regions and has been widely studied in both basic research and clinical neurology. However, its exact anatomy has been controversial. In this study, we proposed to address the anatomy of Wernicke's area by investigating different connectivity profiles. First, the posterior superior temporal gyrus (STG), traditionally called "Wernicke's area", was parcellated into three component subregions with diffusion MRI. Then, whole-brain anatomical connectivity, resting-state functional connectivity (RSFC) and meta-analytic connectivity modeling (MACM) analyses were used to establish the anatomical, resting-state and task-related coactivation network of each subregion to identify which subregions participated in the language network. In addition, behavioral domain analysis, meta-analyses of semantics, execution speech, and phonology and intraoperative electrical stimulation were used to determine which subregions were involved in language processing. Anatomical connectivity, RSFC and MACM analyses consistently identified that the two anterior subregions in the posterior STG primarily participated in the language network, whereas the most posterior subregion in the temporoparietal junction area primarily participated in the default mode network. Moreover, the behavioral domain analyses, meta-analyses of semantics, execution speech and phonology and intraoperative electrical stimulation mapping also confirmed that only the two anterior subregions were involved in language processing, whereas the most posterior subregion primarily participated in social cognition. Our findings revealed a convergent posterior anatomical border for Wernicke's area and indicated that the brain's functional subregions can be identified on the basis of its specific structural and functional connectivity patterns.
Impact of oxygen-enriched SiN interface on Al/sub 2/O/sub 3/ gate stack. An innovative solution to low-power CMOS (2004)

A SiN dielectric with oxygen-enriched interface (OI-SiN) was applied as an interfacial layer of an Al/sub 2/O/sub 3/ stack. The OI-SiN interface, where the nitrogen profile is controlled and the fixed charge is suppressed, can solve critical issues for high-/spl kappa/ dielectrics; impurity penetration through conventional processes, and reduced mobility due to Coulomb scattering. Thus, the drivability with low-leakage current is ensured. We show a scaling strategy to integrate the OI-SiN/Al/sub 2/O/sub 3/ stack which is suitable for low-power applications.
Obstructive Uropathy as a Complication of Hematometrocolpos in an Adolescent Female: A Case Report (2023)

Obstructive uropathy, secondary to mass obstructing effects such as hematometrocolpos and consequent acute urinary retention (AUR); is a proven but rare condition in females. Imperforated hymen, which is found in 0.05-0.1% of females, obstructs blood flow at the onset of mensuration with a resultant hematometrocolpos presenting most commonly with abdominal pain and urinary symptoms in the background of primary amenorrhea, which is similar to the presentation of the 11 years old female in the case report. She had abdominal pain and dysuria, which AUR followed for 16 hours. The patient was at Tunner stage 3, and the examination revealed a palpable tender pelvic mass up to the umbilicus level with a bulging introitus and an imperforated hymen. Ultrasonography confirmed hematometrocolpos and an associated bilateral grade 2 hydronephrosis. Therefore, hymenotomy and excision of hymenal edges were done. Although diagnosis can be directed by physical examination, it can be significantly delayed or missed due to generally low incidence rate and insufficient physical examination due to cultural and religious reasons. This case report directs toward the importance of high clinical suspicion of hematometrocolpos as a cause of AUR in adolescent females and the necessity of a complete detailed physical examination, although it is rare.
Clinical and molecular features of low prostate-specific membrane antigen (PSMA) expression in patients (pts) with metastatic castration resistant prostate cancer (mCRPC). (2022)

167 Background: Low PSMA uptake on positron-emission tomography is seen in up to 30% of mCRPC pts and represents a clinically distinct subgroup with adverse outcomes. We assessed transcriptional and clinical features associated with low PSMA ( FOLH1) gene expression in mCRPC. Methods: A retrospective analysis of mCRPC biopsy samples with RNA-seq data was undertaken. Normalized FOLH1 expression was compared across histologic subtypes and sites of disease. We assessed the association between FOLH1 expression, selected androgen receptor (AR) target genes, master regulators of neuroendocrine differentiation, and previously validated AR activity and treatment-associated small cell neuroendocrine carcinoma (t-SCNC) transcriptional signature scores using Pearson correlations. Associations between FOLH1 and both PSA 50 response to subsequent AR-targeted therapy and overall survival (OS) were examined by logistic regression and Cox proportional hazard models, respectively. Results: Samples from 97 pts were identified, of which 18% harbored t-SCNC histology. 45% of pts had visceral metastases at the time of biopsy, and 41% received subsequent AR-targeted therapy. Median FOLH1 expression was lower in pts with visceral metastases vs no visceral metastases (14.7 vs 15.6, p = 0.02) but was not significantly different across t-SCNC vs adenocarcinoma biopsies (14.3 vs 15.4, p = 0.13). FOLH1 expression was positively correlated with AR transcriptional activity and AR target genes, and negatively correlated with master regulators of neuroendocrine differentiation and t-SCNC transcriptional signature scores (Table). Low FOLH1 expression did not predict PSA 50 response to subsequent AR-targeted therapy (OR 0.97, p = 0.8), but was associated with shorter OS on univariate analysis (HR 1.09, 95% CI 1.02-1.16, p=0.01). A post-hoc analysis revealed a trend towards decreased median OS in pts with FOLH1 expression &lt;12 (7.5 vs 17.1 months, log-rank p = 0.06). Conclusions: In this retrospective analysis of mCRPC pts, low FOLH1 expression was associated with transcriptional features of t-SCNC, decreased AR activity, and shorter OS. These findings are hypothesis-generating and prospective validation is needed.[Table: see text]