gebhart/patrepeval huggingface dataset:
8.4 A 0.33V/-40&#x00B0;C process/temperature closed-loop compensation SoC embedding all-digital clock multiplier and DC-DC converter exploiting FDSOI 28nm back-gate biasing (2015)

A 32b SoC is designed in 28nm FDSOI to operate in either an energy-efficiency (EE) mode, at 0.45V, or low-leakage (LL) mode, at 0.33V, with process-temperature compensation. At near threshold, it overcomes low transistor current at negative temperatures, the need for an extra digital supply IO, and the clocking power costs faced by the internet-of-things (IoT) and wearable systems. The system includes: 1) an all-digital single-supply open-loop clock multiplier achieving 1.51 pJ/cycle; 2) a 0.33V/0.45V dual-mode switched-network-capacitor DC-DC down converter from a 1.1V logic supply, reaching 75% conversion efficiency in both modes; 3) a closed-loop low-invasiveness timing monitoring system dynamically compensating device centering and temperature changes, enabling constant frequency operation down to -40°C at 20MHz (1MHz) in EE (LL) mode. The system fully exploits forward body bias (FBB) available in 28nm UTBB FDSOI with LVT transistors.
Submerged Fermentation of the Edible Mushroom Pleurotus ostreatus in a Batch Stirred Tank Bioreactor as a Promising Alternative for the Effective Production of Bioactive Metabolites (2012)

The aim of this study was to investigate the potential of the submerged fermentation procedure in the production of bioactive metabolites of the common edible mushroom Pleurotus ostreatus. The biomass of the mushroom strain was produced by submerged fermentation in a batch stirred tank bioreactor and extracted by solvents of increasing polarity. The dichloromethane and methanol extract were fractioned by different techniques including Adsorption Chromatography and Fast Centrifugal Partition Chromatography (FCPC). The structures of pure compounds were elucidated with 1D/2D NMR-spectroscopic analyses, and chemical correlations combined with GC/MS and LC/MS experiments. Nineteen metabolites (e.g., fatty acids, phenolic metabolites, nucleotides and alkaloids) were isolated. Beyond the production of known metabolites, we report herein the production also of trans-3,4-dihydro-3,4,8-trihydroxynapthalen-1(2H)-one, indolo-3-carboxylic acid, 3-formylpyrrole and 4-hydroxybenzoic acid, that have pharmaceutical interest and are isolated for the first time from Pleurotus strains. This work indicates the great potential of the established bioprocess for the production of P. ostreatus mycelia with enhanced metabolic profile.
Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. (1992)

BSAP has been identified previously as a transcription factor that is expressed at early, but not late, stages of B-cell differentiation. Biochemical purification and cDNA cloning has now revealed that BSAP belongs to the family of paired domain proteins. BSAP is encoded by the Pax-5 gene and has been highly conserved between human and mouse. An intact paired domain was shown to be both necessary and sufficient for DNA binding of BSAP. Binding studies with several BSAP recognition sequences demonstrated that the sequence specificity of BSAP differs from that of the distantly related paired domain protein Pax-1. During embryogenesis, the BSAP gene is transiently expressed in the mesencephalon and spinal cord with a spatial and temporal expression pattern that is distinct from that of other Pax genes in the developing central nervous system (CNS). Later, the expression of the BSAP gene shifts to the fetal liver where it correlates with the onset of B lymphopoiesis. BSAP expression persists in B lymphocytes and is also seen in the testis of the adult mouse. All of this evidence indicates that the transcription factor BSAP may not only play an important role in B-cell differentiation but also in neural development and spermatogenesis.
Siloxane-modified polyethersulfideimide (1987)

BDSDA/APB, a novel linear polyethersulfideimide, was synthesized using siloxane units as flexible linkages in the backbone in an attempt to improve use properties and processability. The effect of these flexible linkages on molecular weight buildup (Mn and Mw), GIc, flexural strength and modulus, glass transition temperature, and melt-flow properties was determined.
Perlecan-Containing Pericellular Matrix Regulates Solute Transport and Mechanosensing Within the Osteocyte Lacunar-Canalicular System (2013)

The pericellular matrix (PCM), a thin coating surrounding nearly all mammalian cells, plays a critical role in many cell-surface phenomena. In osteocytes, the PCM is believed to control both "outside-in" (mechanosensing) and "inside-out" (signaling molecule transport) processes. However, the osteocytic PCM is challenging to study in situ because it is thin (∼100 nm) and enclosed in mineralized matrix. To this end, we recently developed a novel tracer velocimetry approach that combined fluorescence recovery after photobleaching (FRAP) imaging with hydrodynamic modeling to quantify the osteocytic PCM in young murine bone. In this study, we applied the technique to older mice expressing or deficient for perlecan/HSPG2, a large heparan-sulfate proteoglycan normally secreted in osteocytic PCM. The objectives were (1) to characterize transport within an altered PCM; (2) to test the sensitivity of our approach in detecting the PCM alterations; and (3) to dissect the roles of the PCM in osteocyte mechanosensing. We found that: (1) solute transport increases in the perlecan-deficient (hypomorphic [Hypo]) mice compared with control mice; (2) PCM fiber density decreases with aging and perlecan deficiency; (3) osteocytes in the Hypo bones are predicted to experience higher shear stress (+34%), but decreased fluid drag force (-35%) under 3-N peak tibial loading; and (4) when subjected to tibial loading in a preliminary in vivo experiment, the Hypo mice did not respond to the anabolic stimuli as the CTL mice did. These findings support the hypothesis that the PCM fibers act as osteocyte's sensing antennae, regulating load-induced cellular stimulations and thus bone's sensitivity and in vivo bone adaptation. If this hypothesis is further confirmed, osteocytic PCM could be new targets to develop osteoporosis treatments by modulating bone's intrinsic sensitivity to mechanical loading and be used to design patient-specific exercise regimens to promote bone formation.
Dependence of relationship between chemical gradient and line width roughness of zirconia nanoparticle resist on pattern duty, acid generator, and developer (2019)

Abstract Metal oxide nanoparticle resists are promising materials for highly-resolving high-throughput patterning. However, their performance is still inadequate for the application to the production of semiconductor devices. In this study, the dependence of the relationship between chemical gradient and line width roughness (LWR) on the pattern duty, acid generator, and developer was investigated using a zirconia (ZrO 2 ) nanoparticle resist. The line-and-space patterns of ZrO 2 nanoparticle resists were analyzed on the basis of the extreme ultraviolet sensitization mechanism. LWR was roughly inversely proportional to the chemical gradient. The proportionality constant decreased with the increase of the ratio of nominal space width to the nominal line width. The proportionality constant for n -butyl acetate was smaller than that for an alternative developer with a high polarity. The proportionality constant decreased by the addition of an acid generator. The improvement of dissolution process and the suppression of secondary electron migration are essential to the suppression of LWR in the ZrO 2 nanoparticle resist.
Low-Cost Surrogate Models for Microwave Filters (2016)

A novel low-cost kriging-based multivariable parametric macromodeling technique for microwave filters is presented. Kriging is used to model both the residues and poles of a microwave filter's reflection coefficient, and the zeros of the transmission coefficient. The proposed residue-pole-zero (RPZ) technique is demonstrated to efficiently model a high dimensional (8D) microwave filter with pseudoelliptic characteristics.
Supplementary Table 3 from Dysregulation of EGFR Pathway in EphA2 Cell Subpopulation Significantly Associates with Poor Prognosis in Colorectal Cancer (2023)

&lt;p&gt;Supplementary Table 3 - Univariate and multivariate analyses of factors affecting PFS in patients who received Cetuximab monotherapy belonging to EphA2high group (cohort 5, N=40).&lt;/p&gt;
Molecular Imaging of Hemoglobin for Vasculature Mapping Using ground state recovery Pump-Probe Optical Coherence Tomography (gsrPPOCT) (2006)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text B. E. Applegate and J. A. Izatt, "Molecular Imaging of Hemoglobin for Vasculature Mapping Using ground state recovery Pump-Probe Optical Coherence Tomography (gsrPPOCT)," in Biomedical Optics, Technical Digest (CD) (Optica Publishing Group, 2006), paper WC5. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Retroviral transfer of a chimeric multidrug resistance‐adenosine deaminase gene (1990)

A fusion between a selectable multidrug resistance (MDR1) cDNA and an adenosine deaminase (ADA) cDNA concomitantly confers multidrug resistance and ADA activity on transfected cells. We have produced a Harvey murine sarcoma virus-derived, replication-defective, recombinant retrovirus to transduce this chimeric MDR-ADA gene efficiently into a great variety of cells. Infection with the MDR-ADA retrovirus conferred the multidrug resistance phenotype on drug-sensitive cells, therefore allowing selection in the presence of colchicine. Colchicine-resistant cells synthesized large amounts of a membrane-associated 210-kDa MDR-ADA fusion protein that preserved both MDR and ADA functional activities. To monitor expression of the chimeric gene in vivo, Kirsten virus-transformed NIH cells were infected with the MDR-ADA retrovirus, and after drug-selection, injected into athymic nude mice. Tumors developed that contained the bifunctionally active MDR-ADA fusion protein. When these mouse tumor cells were placed in tissue culture without the selecting drug, they did not lose the bifunctionally active MDR-ADA fusion protein. The replication-defective, recombinant MDR-ADA retrovirus should be useful to stably introduce the chimeric MDR-ADA gene into a variety of cell types for biological experiments in vitro and in vivo.
Improving gasification economics through ITM oxygen integration (2002)

A recent study assessed the impact of ITM Oxygen on economics for IGCC. Compared to a highly-integrated state-of-the-art cryogenic air separation unit (ASU) utilizing an elevated pressure, partially pumped LOX design, the ITM Oxygen plant is projected to decrease the installed specific cost (dollars/m TPD) of air separation equipment by 35%. Such savings decrease the installed capital cost of the overall IGCC facility by 7% from 1,094 dollars/kW to 1.020 dollars/kW, while the efficiency also improves by one percentage point. Another potential application for ITM Oxygen technology comprises a 'decarbonized fuel plant' that produces pure hydrogen from fossil fuels while recovering carbon dioxide for offsite processing or sequestration. An integration study with one of these designs projected that an ITM Oxygen plant would save 25-35% of the installed cost for air separation equipment and more than 4% of the total facility cost, while generating ultra-clean power as a co-product. These results are consistent with ITM Oxygen integration studies performed on other advanced power system designs, and they underscore the expected economic benefits of ITM Oxygen technology. 6 figs., 4 tabs.
The Pierre Auger Observatory IV: Operation and Monitoring (2011)

Technical reports on operations and monitoring of the Pierre Auger Observatory
Localized Bright Luminescence of Indirect Excitons and Trions in a Type II Van der Waals Heterostructure (2019)

We observe order of magnitude intensity enhancement and narrow, 4 meV, linewidth of luminescence of indirect (interlayer) neutral and charged excitons in localized spot in MoSe2/WSe2 heterostructure. The indirect trion binding energy is 26 meV.
Time Reversal Acoustic focusing using layered membranes structure (2008)

In the recent years numerous Time Reversal Acoustic Focusing Systems (TRA FS) employing various reverberation chambers ("acoustic cavities") accumulating acoustic energy in time were described in the literature. We propose an alternative reverberator composed of a liquid-filled volume comprising a series of spatially distributed membranes with varying thickness in the range from one quarter to half wavelength of ultrasound. Random spatial variation of ultrasound reflection from such membranes leads to randomization of acoustic field that highly improve Time Reversal focusing of the system. A theoretical model of reflections from nonuniform membranes is suggested to evaluate spatial and temporal characteristics of TRA focusing formed as a result of numerous reflections and reverberation of ultrasound propagating though the plurality of membranes. The dependence of focal structure and focused waveform was investigated for suggested structure and their focusing efficiency has been compared with that of the conventional reverberators. In the experiment, the membrane were made of Polyethylene Terephthalate or Nylon thermoformed films. Ultrasonic signals were radiated by transducers with frequency in the range from 3 to 10 MHz. Experiment demonstrated effective TRA focusing by membrane arrangement that can be used for ultrasound focusing and steering in various minimally-invasive biomedical applications.
Verification of emulated channels in multi-probe based MIMO OTA testing setup (2013)

Standardization work for MIMO OTA testing methods is currently ongoing, where a multi-probe anechoic chamber based solution is an important candidate. In this paper, the probes located on an OTA ring are used to synthesize a plane wave field in the center of the OTA ring. This paper investigates the extent to which we can approach the synthesized plane wave in practical measurement systems. Both single plane wave with certain AoA and multiple plane waves with different AoAs and<br/>power weightings are synthesized and measured. Deviations of the measured plane wave and the simulated plane wave field are presented in terms of phase and power. Possible reasons for the deviations are also investigated.
Chemical Reactions in the Axle of Rotaxanes – Steric Hindrance by the Wheel (1999)

Here we report on the possibility of using rotaxane wheels as noncovalent protecting groups which significantly decrease the activity of functional groups in the central part of the axle. The amide-linked rotaxanes 5aand 5b, each containing a CC double bond in their axle, have been synthesised. The catalytic hydrogenation of these two rotaxanes proceeds slower than those of the corresponding free axle compounds 6a and 6b, indicating steric hindrance of the CC double bond by the wheel of the rotaxane in each case. Nontheless, the rotaxane 9with an aliphatic (succinic acid) middle region in its axle can be prepared in this manner. Dehydrobromination of the axle in the rotaxane 15yields the rotaxane 16 with a C≡C triple bond located in the centre of the axle.
Extraction of Am(III) at the Interface of Organic-Aqueous Two-Layer Flow in a Microchannel (2011)

Extraction of Am(III) was performed at the interface of organic-aqueous two-layer flow in a micro-channel having an asymmetric cross section. A solution of 3 mol/dm3 nitric acid containing 243Am(III) and octyl(phenyl)-N,N-diisobutylcarbamoylmethylphosphineoxide diluted with n-dodecane were introduced into the microchannel as the aqueous phase and organic phase, respectively. The two phases formed a stable two-layer flow with an interface parallel to the sidewall of the microchannel, and they were separated from each other at the divergence point of the microchannel. The extraction reaction of Am(III) proceeded at the interface of the two phases, and reached the equilibrium state while the two phases passed through the microchannel.
Effective capacity in multiple access channels with arbitrary inputs (2015)

In this paper, we consider a two-user multiple access fading channel under quality-of-service (QoS) constraints. We initially formulate the transmission rates for both transmitters, where the transmitters have arbitrarily distributed input signals. We assume that the receiver performs successive decoding with a certain order. Then, we establish the effective capacity region that provides the maximum allowable sustainable arrival rate region at the transmitters' buffers under QoS guarantees. Assuming limited transmission power budgets at the transmitters, we attain the power allocation policies that maximize the effective capacity region. As for the decoding order at the receiver, we characterize the optimal decoding order regions in the space spanned by channel fading power parameters for given power allocation policies. In order to accomplish the aforementioned objectives, we make use of the relationship between the minimum mean square error and the first derivative of the mutual information with respect to the power allocation policies. Through numerical results, we display the impact of input signal distributions on the effective capacity region performance of this two-user multiple access fading channel.
Inside Cover: Dual Gold(I)‐catalyzed Cyclization of Dialkynyl Pyridinium Salts (ChemCatChem 11/2017) (2017)

The Cover depicts our research as the final task of Ulysses. The golden bow represents the gold catalyst IPrAuNTf2, also present in the golden flasks, which operates the initial cyclization. Just as Ulysses had to shoot the arrow through the axes, here the two Pd axes are atop a black Pd/C mound to symbolize the regio- and chemoselectivity of the two sequential hydrogenations. The arrows remain in the final product to show that the hydrides are all added synfacially. In their Full Paper, Tšupova, Cadu et al. demonstrate that the overall reaction can be conducted in one pot, with two metal catalysts over three reaction steps, to cyclize and reduce the pyridinium salts to free hexahydropentalenopyridines. Cover designed by Dr. Svetlana Tšupova. More information can be found in the Full Paper by Tšupova, Cadu et al. on page 1915 in Issue 11, 2017 (DOI: 10.1002/cctc.201700018).
Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism (2020)

Abstract Genome-wide analysis of the mode of action of GSK983, a potent antiviral agent, led to the identification of dihydroorotate dehydrogenase (DHODH) as its target, along with the discovery that knockdown of genes in pyrimidine salvage pathways sensitized cells to GSK983. Because GSK983 is an ineffective antiviral in the presence of physiological uridine concentrations, we explored combining GSK983 with pyrimidine salvage inhibitors. We synthesized and evaluated analogs of cyclopentenyl uracil (CPU), an inhibitor of uridine salvage. We found that CPU was efficiently converted into its triphosphates in cells. When combined with GSK983, it led to large drops in cellular UTP and CTP pools. Consequently, CPU-GSK983 suppressed dengue virus replication in the presence of physiological concentrations of uridine. In addition, the CPU-GSK983 combination markedly enhanced the effect of RNA-dependent RNA polymerase (RdRp) inhibition on viral genome infection. Our findings highlight a new host-targeting strategy for potentiating the antiviral activities of RdRp inhibitors.
Diagnosis of Acute Q Fever by PCR on Sera during a Recent Outbreak in Rural South Australia (2006)

Diagnosis of Q fever has largely been dependent upon serology, which may lead to delayed diagnosis as seroconversion can take weeks to develop. During a recent Q fever outbreak (27 patients) in rural South Australia, we compared the diagnostic rate of serology with two separate real-time PCRs, the 27kDa outer membrane protein and the insertion sequence. PCR was positive (on either or both PCR assays) in sera of 67% of the patients. Median time required for making serological diagnosis was 17 days, compared with 4 days by PCR. Q fever PCR is an effective tool in the diagnosis of acute Q fever infection.
Drugs vs. ablation for the treatment of atrial fibrillation: the evidence supporting catheter ablation (2010)

Treatment strategy for atrial fibrillation (AF) is a controversial matter. Catheter ablation is increasingly being used to treat patients with AF, and recent studies have reported success rates >80% for paroxysmal AF and >70% for persistent AF. The purpose of this work is to review the evidence supporting catheter ablation and compare it with pharmacological treatment in the management of AF.
Rate of Increase and Adult Longevity ofCatolaccus grandis(Burks) (Hymenoptera: Pteromalidae) in the Laboratory at Four Temperatures (1992)

The reproductive potential and longevity of adult females of Catolaccus grandis (Burks) (an exotic parasitoid of the cotton boll weevil) were determined under laboratory conditions at four constant temperatures (25, 30, 35, and 40°C ± 1). The resulting data were used to calculate life tables and rates of increase at each temperature. The effect of food and water availability on longevity at 25, 30, and 35°C was evaluated on groups of 10 adult wasps. A female of C. grandis oviposited means of 679.24,498.8,76.15, and 0.0 eggs at 25, 30, 35, and 40°C, respectively, and had a mean longevity of 63.55, 46.35, 20.8, and 9.0 d at the same four temperatures respectively. The net reproductive rate was 58.4, 28.35,4.3, and 0.0; the daily intrinsic rate of increase was 0.134, 0.159, 0.082, and 0.0; and the weekly rate of increase was 1.052, 1.327, 0.692, and 0.0 at 25, 30, 35, and 40°C, respectively. The food treatments that included honey significantly increased longevity with respect to those treatments that lacked it. Treatment including only water did not increase longevity significantly with respect to the control (no food or water).
Effect of oxygen on performance and mass transport in a single-cell thermionic fuel element (2002)

The introduction of tracer amounts of oxygen into the interelectrode gap of a thermionic converter has been shown to improve converter performance. Excess oxygen, however, increases the loss rate of emitter material, reducing the converter performance and shortening its lifetime, owing to the increase in the effective emissivity of the electrodes, the change in the collector work function, and the deposition of emitter material oxides on spacers and insulators. In this paper, a model was developed which calculated the emitter material loss rate, composition of the emitter material deposits on the collector surface and investigated the effect of performance of a single-cell thermionic fuel element (TFE) in the presence of oxygen and cesium oxides in the interelectrode gap. The amount of oxygen and the cesium pressure in the interelectrode gap were varied parametrically and the TFE volt-ampere characteristics, and axial distributions of current density and emitter material loss rate along the TFE were calculated.
Use of HLA-B*58:01 genotyping to prevent allopurinol induced severe cutaneous adverse reactions in Taiwan: national prospective cohort study (2015)

Prospective screening of the HLA-B*58:01 allele, coupled with an alternative drug treatment for carriers, significantly decreased the incidence of allopurinol induced SCARs in Taiwanese medical centres.