gebhart/patrepeval huggingface dataset:
Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors (2001)

Vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) regulate colon cancer growth and metastasis. Previous studies utilizing antibodies against the VEGF receptor (DC101) or EGF receptor (C225) have demonstrated independently that these agents can inhibit tumour growth and induce apoptosis in colon cancer in in vivo and in vitro systems. We hypothesized that simultaneous blockade of the VEGF and EGF receptors would enhance the therapy of colon cancer in a mouse model of peritoneal carcinomatosis. Nude mice were given intraperitoneal injection of KM12L4 human colon cancer cells to generate peritoneal metastases. Mice were then randomized into one of four treatment groups: control, anti-VEGFR (DC101), anti-EGFR (C225), or DC101 and C225. Relative to the control group, treatment with DC101 or with DC101+C225 decreased tumour vascularity, growth, proliferation, formation of ascites and increased apoptosis of both tumour cells and endothelial cells. Although C225 therapy did not change any of the above parameters, C225 combined with DC101 led to a significant decrease in tumour vascularity and increases in tumour cell and endothelial cell apoptosis (vs the DC101 group). These findings suggest that DC101 inhibits angiogenesis, endothelial cell survival, and VEGF-mediated ascites formation in a murine model of colon cancer carcinomatosis. The addition of C225 to DC101 appears to lead to a further decrease in angiogenesis and ascites formation. Combination anti-VEGF and anti-EGFR therapy may represent a novel therapeutic strategy for the management of colon peritoneal carcinomatosis.
In utero exposure to maternal anti–aquaporin-4 antibodies alters brain vasculature and neural dynamics in male mouse offspring (2022)

The fetal brain is constantly exposed to maternal IgG before the formation of an effective blood-brain barrier (BBB). Here, we studied the consequences of fetal brain exposure to an antibody to the astrocytic protein aquaporin-4 (AQP4-IgG) in mice. AQP4-IgG was cloned from a patient with neuromyelitis optica spectrum disorder (NMOSD), an autoimmune disease that can affect women of childbearing age. We found that embryonic radial glia cells in neocortex express AQP4. These cells are critical for blood vessel and BBB formation through modulation of the WNT signaling pathway. Male fetuses exposed to AQP4-IgG had abnormal cortical vasculature and lower expression of WNT signaling molecules <i>Wnt</i>5a and <i>Wnt</i>7a. Positron emission tomography of adult male mice exposed in utero to AQP4-IgG revealed increased blood flow and BBB leakiness in the entorhinal cortex. Adult male mice exposed in utero to AQP4-IgG had abnormal cortical vessels, fewer dendritic spines in pyramidal and stellate neurons, and more S100β<sup>+</sup> astrocytes in the entorhinal cortex. Behaviorally, they showed impairments in the object-place memory task. Neural recordings indicated that their grid cell system, within the medial entorhinal cortex, did not map the local environment appropriately. Collectively, these data implicate in utero binding of AQP4-IgG to radial glia cells as a mechanism for alterations of the developing male brain and adds NMOSD to the conditions in which maternal IgG may cause persistent brain dysfunction in offspring.
Optical model for spectroscopic ellipsometry analysis of plasma-induced damage to SiOC films (2017)

We propose a new optical model for assigning the physical structure of plasma-damaged SiOC films examined by spectroscopic ellipsometry. A two-parameter Bruggeman's effective medium approximation is used for estimating the thickness and volume fraction of a low-dielectric (ε) region (ε ∼ 1) in the SiO2 background. We introduced an optical model consisting of damaged and undamaged layers. The thickness and fraction of the damaged layer are fitted. Prediction was performed using this model for SiOC samples exposed to various plasmas, and the results were compared with those of scanning electron microscopy. We further applied this model to estimating the depth of damaged region in combination with a layer-by-layer wet-etching technique. In the case of He plasma exposure, the structural change induced by the damage extends 90–130 nm in depth. Since the degradation of interlayer dielectrics affects the circuit performance, the proposed optical model should be used for designing plasma processes.
Anisotropic cerebral vascular architecture causes orientation dependency in cerebral blood flow and volume measured with dynamic susceptibility contrast magnetic resonance imaging (2016)

Measurements of cerebral perfusion using dynamic susceptibility contrast magnetic resonance imaging rely on the assumption of isotropic vascular architecture. However, a considerable fraction of vessels runs in parallel with white matter tracts. Here, we investigate the effects of tissue orientation on dynamic susceptibility contrast magnetic resonance imaging. Tissue orientation was measured using diffusion tensor imaging and dynamic susceptibility contrast was performed with gradient echo planar imaging. Perfusion parameters and the raw dynamic susceptibility contrast signals were correlated with tissue orientation. Additionally, numerical simulations were performed for a range of vascular volumes of both the isotropic vascular bed and anisotropic vessel components, as well as for a range of contrast agent concentrations. The effect of the contrast agent was much larger in white matter tissue perpendicular to the main magnetic field compared to white matter parallel to the main magnetic field. In addition, cerebral blood flow and cerebral blood volume were affected in the same way with angle-dependent variations of up to 130%. Mean transit time and time to maximum of the residual curve exhibited weak orientation dependency of 10%. Numerical simulations agreed with the measured data, showing that one-third of the white matter vascular volume is comprised of vessels running in parallel with the fibre tracts.
Effects of Juice Processing on Anti-inflammatory Flavonoids in Plant Foods (2009)

Apigenin glycosides are abundant in parsley, celery, and chamomile tea and possess unique anti-inflammatory properties in vitro. Apigenin O-glycosides have been evaluated in foods by hydrolysis and comparison to aglycone standards, but intact O- and C-glycosides of apigenin cannot be directly identified by these methods. As the stability and bioavailability of flavonoids depends on their structure, it is important to identify and quantify intact apigenoids (apigenin O- and C-glycosides) in fresh and processed foods. Apigenoids in fresh parsley and celery were compared with those in juices. Fresh samples were lyophilized and extracted with 70% (v/v) aqueous methanol (3 ml solvent:50 mg sample), and juices extracted with 50% (v/v) methanol. Extracts were analyzed by reversed-phase HPLC with photodiode array detection to identify and quantify flavonoids versus standards. Peak identities were determined by electrospray mass spectrometry using in-source fragmentation to liberate aglycones. In fresh celery and parsley, the predominant apigenoid was apigenin O-malonylapiosylglucoside (malonylapiin), with lesser amounts of apigenin O-apiosylglucoside (apiin); in celery and parsley juices, apiin was the predominant form. Total apigenoid concentrations were 5-25 mg/100 g (wet basis) in celery and juice, and 130-160 mg/100 g in parsley and juice. We found that anti-inflammatory flavonoids were slightly modified but largely retained during juice processing. Our method could be used to rapidly screen for other flavonoids, including C-glycosides, and similar derivatives in foods.
ChemInform Abstract: Reducing Them Down To Charge Them Up: Low Temperature Catalyst Activation (2016)

Abstract Review: 9 refs.
Active infrared materials for beam steering. (2010)

The mid-infrared (mid-IR, 3 {micro}m -12 {micro}m) is a highly desirable spectral range for imaging and environmental sensing. We propose to develop a new class of mid-IR devices, based on plasmonic and metamaterial concepts, that are dynamically controlled by tunable semiconductor plasma resonances. It is well known that any material resonance (phonons, excitons, electron plasma) impacts dielectric properties; our primary challenge is to implement the tuning of a semiconductor plasma resonance with a voltage bias. We have demonstrated passive tuning of both plasmonic and metamaterial structures in the mid-IR using semiconductors plasmas. In the mid-IR, semiconductor carrier densities on the order of 5E17cm{sup -3} to 2E18cm{sup -3} are desirable for tuning effects. Gate control of carrier densities at the high end of this range is at or near the limit of what has been demonstrated in literature for transistor style devices. Combined with the fact that we are exploiting the optical properties of the device layers, rather than electrical, we are entering into interesting territory that has not been significantly explored to date.
Conjugates of insulin with copolymers of N-(2-hydroxypropyl) methacrylamide: Effects on smooth muscle cell proliferation (1996)

The hypothesis that an elevated plasma insulin level contributes to an increase in coronary heart disease has led to studies of the mitogenic effect of native insulin and its conjugates on smooth muscle cells (SMC). In this study, insulin was covalently attached to two water-soluble polymers containing N-(2-hydroxypropyl)methacrylamide using the mixed anhydride method. The first polymer was a copolymer of N-(2-hydroxypropyl)methacrylamide and N-methacryloyldiglycine. The second one was a terpolymer of two of the above-given monomers and R-(-)-1-methyl-2-methacryloylamidoethyl 2-acetamido-2-deoxy-beta-D-glucopyranoside. Insulin conjugates were isolated and characterized, and the mitogenic effect on SMC was investigated. The results showed that only conjugates of insulin and terpolymers bearing pendant N-acetyl-glucosamine groups do not have a mitogenic effect on SMC while maintaining the hypoglycemic activity of insulin. This finding suggests that some inter- or intramolecular interactions of coupled insulin with the sugar moiety(ies) attached to the polymer backbone contribute to the observed effects.
Toward the Accurate Read‐out of Quantum Dot Barcodes: Design of Deconvolution Algorithms and Assessment of Fluorescence Signals in Buffer (2007)

Signal processing methods and constraints for discerning the fluorescence signals of the QD-barcodes are explored. QD-barcodes and their corresponding fluorescence spectra (see figure) require signal processing algorithms in order to be uniquely identified. Using these algorithms, we determined the number of available barcodes for use in biological detection. We also studied the impact of chemical constraints such as buffer and pH level on the barcode and read-out design.
Facile Four-Mask Processes for Organic Thin-Film Transistor Integration Structure With Metal Interconnect (2019)

To enable an organic thin film transistor (OTFT) technology for circuit integration, the passivation layer and subsequent interconnect metallization on top of the OTFT is vital. In this work, a modified SU8 formulation is developed for forming the passivation layer on top of the OTFT with small molecule organic semiconductor (OSC). Based on the single SU8 passivation layer, via holes for interconnect metallization are easily formed, and the whole integration structure can be completed with facile four-mask processes. The OTFTs exhibit high mobility (> 2 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /V · s), low leakage (<; 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-11</sup> A over the whole gate voltage range from 20 V to -30 V) at short channel length (8 μm), excellent uniformity and stable electrical properties during operation and storage. The results well prove that the process of the modified SU8 solution for passivation is compatible with the small molecule OSC layer, and formation of the via connection is reliable.
Investigating an LCL Load Resonant Inverter for Inductive Power Transfer Applications (2004)

A inductor/capacitor/inductor load resonant inverter is investigated for inductive power transfer applications. The inverter uses a variable frequency controller and operates in discontinuous current mode. The steady state operation of this system is determined by a power flow balance between the inverter and the resonant tank. The results are used to design a system to achieve maximum power transfer.
Novel fibers for dispersion-managed high-bit-rate systems (2002)

Summary form only given. Novel dispersion-managed fibers that minimize four-wave mixing (FWM) and other nonlinear effects with built-in dispersion compensation, large effective areas, and low dispersion slopes have been developed. These fibers are also expected to be flexible enough to allow upgrades in both wavelength-division multiplexing and time-division multiplexing approaches. Propagation and FWM efficiency models have been used to optimize the designs and evaluate the system advantages of these fibers.
Predicting error in point-based registration (2001)

Point-based registration is the task of transforming one set of points to try to make it “look like” another set. In this dissertation, we examine the application of point-based registration to stereotactic neurosurgery, and we investigate the way in which the placement of the “fiducial” points (those used for registration) affects the accuracy with which a surgical target may be located. 
In point-based image registration, there are three types of error. Fiducial localization error (FLE) is the imprecision in locating the points used for registration. Fiducial registration error (FRE) is the distance between corresponding fiducial points after registration is performed. Target registration error (TRE) is the distance after registration between corresponding points in the image other than the fiducials. In surgical applications, TRE is the most important error, and limiting TRE is vital for successful surgical navigation. 
In 1979, Sibson used perturbation theory to derive an approximate relationship between FLE and FRE in the case that the registration transform consists of a rotation and translation. We use a similar approach to give for the first time a quantitative relationship between FLE and TRE, and we show that TRE, unlike FRE, is influenced by the shape of the fiducial configuration. We prove by means of numerical simulations that our approximation is sound, and we use clinical data to demonstrate that our theoretical results give a useful predictor of TRE in practice. 
We extend our derivations to the case that the registration transform is a similarity transform, i.e. it consists of rotation, translation, and an isotropic (same in all directions) scale factor. We give an expression for the relationship between FLE and TRE in this case. We apply a maximum likelihood approach to the problem of choosing the scale factor, and we demonstrate that in many cases this approach gives a scale factor that is superior to the one given by the traditional method.
Cross-layer anticipation of ressource allocation for multimedia applications based on SIP signaling over DVB-RCS satellite system (2007)

International audience
Cation ordering and dielectric properties of PMN-PSN relaxors (2000)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation P. K. Davies, L. Farber, M. Valant, M. A. Akbas; Cation ordering and dielectric properties of PMN-PSN relaxors. AIP Conf. Proc. 12 September 2000; 535 (1): 38–46. https://doi.org/10.1063/1.1324438 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Characterization of Ferroelectric Characteristics for Hafnium Zirconium Oxide Capacitors with Refractory Electrodes (2022)

In this work, we investigated the ferroelectric properties of Hf 0.5 Zr 0.5 O 2 (HZO) Metal-Ferroelectric-Metal (MFM) capacitors on various refractory electrodes, including TiN, TaN, W, and Mo. By comparing different electrodes and annealing temperature, we found that the MFM capacitors with TiN and W electrodes showed both higher remanent polarization (2P r ) and lower leakage current for post-metal annealing (PMA) temperatures ranging from 400 °C to 600 °C. Moreover, the MFM capacitor with W electrode showed better saturated polarization-voltage (P-V) curve and less “wake up effect” during the polarization switching cycles, while the MFM capacitor with TiN electrode showed the lowest leakage current. The correlation of crystallization quality studied by X-ray diffraction and the ferroelectric characteristics for each type of MFM capacitors were also presented and compared in this study.
Uphole surveys digitally recorder and processed as multioffset RVSP's (1992)

In France, onshore seismic surveys often include uphole shots in small wells at least to the bottom of the weathered zone, typically 50 m to 180 m deep, and with a surface spacing of about 2 km on the seismic lines. Up to present, these uphole shots are used only to produce a time-depth curve in order to define the velocity model of the near surface layers and calibrate the long wave static corrections. In the 60&apos;s, wavefront diagrams were commonly produced from multioffset uphole time picks (Meissner, 1961, GP, Vol 4, p 533).
Supplementary Table S3 from Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors (2023)

Supplementary Table S3 from Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors
O3‐02‐03: Capacity building for dealing with dementia in developing countries: Lessons from the Maracaibo Aging Study (2012)

Dementia affects an increasing number of individuals and their families worldwide. Most of the affected individuals reside in developing countries, where psychosocial needs are overwhelming, and where dementia is the primary cause of disability. A multilevel strategy was developed and implemented in Venezuela, as part of the Maracaibo Aging Study (MAS), to build and sustain a workforce that 1) brought together a critical mass of dementia researchers, 2) provided early detection of dementia, 3) delivered quality care to individuals with dementia, 4) provided support services to individuals with early-stage dementia and their families, and 5) increased public knowledge about prevention and caregiving. Strategic alliances were established between the University of Zulia, international universities, and local NGOs. Community-based participatory research (CBPR) was used to develop collaborations among academics, clinicians, and communities. The research used a mixed-methods evaluation system, including interviews, process notes, and open-ended and closed survey questions. Training programs were developed at local institutions, with the support of foreign institutions, to strengthen capacity at various interdependent levels. These included certificate programs, courses, postgraduate courses, and training specifically for caregivers and for trainers of caregivers. Working within established networks was key to obtaining funding. Academic outputs—publications, citations, funded grants, etc.—were tallied at individual and institutional levels. Focus groups and interviews ultimately led to a program of knowledge translation and dissemination that engaged thousands of people in public activities related to dementia. It is possible to increase the number of dementia researchers in a developing country, but retaining them is a major challenge. Limited numbers of qualified mentors and teachers continue to be the greatest barrier to education at the doctoral levels. Enhancement of psychosocial capacities was achieved in the present program through mutual interpersonal aid and support. As many modalities of adult learning were incorporated as possible, with particular attention to multi-cultural and literacy issues. This influenced outreach, the way training was designed and textbooks produced. Development of infrastructure between the university and community was essential to maintaining the partnership.
An Efficient Approach to Encoding Context for Spoken Language\n Understanding (2018)

In task-oriented dialogue systems, spoken language understanding, or SLU,\nrefers to the task of parsing natural language user utterances into semantic\nframes. Making use of context from prior dialogue history holds the key to more\neffective SLU. State of the art approaches to SLU use memory networks to encode\ncontext by processing multiple utterances from the dialogue at each turn,\nresulting in significant trade-offs between accuracy and computational\nefficiency. On the other hand, downstream components like the dialogue state\ntracker (DST) already keep track of the dialogue state, which can serve as a\nsummary of the dialogue history. In this work, we propose an efficient approach\nto encoding context from prior utterances for SLU. More specifically, our\narchitecture includes a separate recurrent neural network (RNN) based encoding\nmodule that accumulates dialogue context to guide the frame parsing sub-tasks\nand can be shared between SLU and DST. In our experiments, we demonstrate the\neffectiveness of our approach on dialogues from two domains.\n
A Scalable Methodology for Agile Chip Development with Open-Source Hardware Components (2022)

We present a scalable methodology for the agile physical design of tile-based heterogeneous system-on-chip (SoC) architectures that simplifies the reuse and integration of open-source hardware components. The methodology leverages the regularity of the on-chip communication infrastructure, which is based on a multi-plane network-on-chip (NoC), and the modularity of socket interfaces, which connect the tiles to the NoC. Each socket also provides its tile with a set of platform services, including independent clocking and voltage control. As a result, the physical design of each tile can be decoupled from its location in the top-level floorplan of the SoC and the overall SoC design can benefit from a hierarchical timing-closure flow, design reuse and, if necessary, fast respin. With the proposed methodology we completed two SoC tapeouts of increasing complexity, which illustrate its capabilities and the resulting gains in terms of design productivity.