gebhart/patrepeval huggingface dataset:
Integrated layer processing can be hazardous to your performance (1997)

Integrated Layer Processing (ILP) has been presented as an implementation technique to improve communication protocol performance by reducing the number of memory references. Previous research has however not pointed out that in some circumstances ILP can significantly increase the number of memory references, resulting in lower communication throughput. We explore the performance effects of applying ILP to data manipulation functions with varying characteristics. The functions are generated from a set of parameters including input and output block size, state size and number of instructions. We present experimental data for varying function state sizes, number of integrated functions and instruction counts. The results clearly show that the aggregated state of the functions must fit in registers for ILP to be competitive. Keywords ILP, Integrated Layer Processing, performance, protocol implementation Supported by the Swedish National Board for Industrial and Technical Development,...
Major photoaffinity drug labeling sites for iodoaryl azidoprazosin in P-glycoprotein are within, or immediately C-terminal to, transmembrane domains 6 and 12 (1993)

P-glycoprotein can mediate multidrug resistance in tumor cells and is hypothesized to be an energy-dependent drug efflux pump. The protein is composed of two cassettes; each cassette contains six transmembrane domains followed by a nucleotide binding fold. The [125I]iodoaryl azidoprazosin photoaffinity drug binding sites in P-glycoprotein have been mapped by immunological analysis. After complete digestion of P-glycoprotein with trypsin, two major photolabeled fragments have been mapped. The 5- and 4-kDa fragments are located within, or immediately C-terminal to, the last transmembrane domain of each cassette: transmembranes 6 and 12 of P-glycoprotein, respectively. The 4-kDa fragment maximally extends up to, but not including, the Walker A motif of the second nucleotide binding fold, whereas the 5-kDa fragment maximally extends a few residues beyond the Walker A motif of the first nucleotide binding fold. A minor photolabeling domain is also found between transmembrane domain 4 and up to, but not including, transmembrane domain 6. These data suggest that a portion of the drug binding site in P-glycoprotein is in close proximity to ATP binding regions. Furthermore, symmetrical regions in each cassette of P-glycoprotein are likely to participate in drug efflux.
Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure (2022)

Chimeric antigen receptor (CAR) T cell therapies have resulted in profound clinical responses in the treatment of CD19-positive hematological malignancies, but a significant proportion of patients do not respond or relapse eventually. As an alternative to CAR T cells, T cells can be engineered to express a tumor-targeting T cell receptor (TCR). Due to HLA restriction of TCRs, CARs have emerged as a preferred treatment moiety when targeting surface antigens, despite the fact that functional differences between engineered TCR (eTCR) T and CAR T cells remain ill-defined. Here, we compared the activity of CAR T cells versus engineered TCR T cells in targeting the B cell malignancy-associated antigen CD20 as a function of antigen exposure. We found CAR T cells to be more potent effector cells, producing higher levels of cytokines and killing more efficiently than eTCR T cells in a short time frame. However, we revealed that the increase of antigen exposure significantly impaired CAR T cell expansion, a phenotype defined by high expression of coinhibitory molecules and effector differentiation. In contrast, eTCR T cells expanded better than CAR T cells under high antigenic pressure, with lower expression of coinhibitory molecules and maintenance of an early differentiation phenotype, and comparable clearance of tumor cells.
Deactivation studies of a carbon supported AuPt nanoparticulate catalyst in the liquid-phase aerobic oxidation of 1,2-propanediol (2014)

The aerobic oxidation of 1,2-propanediol in alkaline aqueous solvent over bimetallic AuPt/C catalysts has been studied and catalyst reusability has been assessed.
All that glitters need not be gold (2015)

Refractory plasmonic ceramics provide durable nanophotonic solutions
A Memory Hierarchical Layer Assigning and Prefetching Technique to Overcome the Memory Performance/Energy Bottleneck (2005)

The memory subsystem has always been a bottleneck in performance as well as significant power contributor in memory intensive applications. Many researchers have presented multi-layered memory hierarchies as a means to design energy and performance efficient systems. However, most of the previous work does not explore trade-offs systematically. We fill this gap by proposing a formalized technique that takes into consideration data reuse, limited life-time of the arrays of an application and application specific prefetching opportunities, and performs a thorough tradeoff exploration for different memory layer sizes. This technique has been implemented on a prototype tool, which was tested successfully using nine real-life applications of industrial relevance. Following this approach we have able to reduce execution time up to 60%, and energy consumption up to 70%.
A dose‐ranging study of ranitidine and its effect on intragastric and intra‐oesophageal acidity in subjects with gastro‐oesophageal reflux disease (1994)

If these higher doses of ranitidine are confirmed to be more effective than the standard 150 mg b.d. regimen for the treatment of patients with gastro-oesophageal reflux disease, then the mechanism of this action probably relates to the lower exposure of the oesophageal mucosa to acid.
Self-Separation of Large Freestanding Semipolar {1122} GaN Films Using r-Plane Patterned Sapphire Substrates (2013)

We have studied the growth of semipolar GaN from the etched sapphire sidewall of a patterned sapphire substrate (PSS). In this work, we grew a thick {112̄2} GaN layer on an r -plane PSS ( r -PSS) by hydride vapor phase epitaxy (HVPE) and separated the GaN layer from the r -PSS. We demonstrated the self-separation of the {112̄2} GaN layer from the r -PSS by using a PSS and thick GaN growth. The ease of separation of the GaN layer from the PSS depended on the selective growth area of the sapphire sidewall. Consequently, we obtained a freestanding {112̄2} GaN film of 2-in. diameter. The dark spot density of this film was 2.8×10 7 /cm 2 .
Topological Nature of Optical Bound States in the Continuum and it Application for Generating High-order Vector beams (2015)

We demonstrate all robust bound states in the continuum in photonic crystal slabs are vortex centers in the polarization directions of far-field radiation. They are robust because they carry quantized topological charges, which are conserved if the system is invariant under parity-time (PT) and up-down mirror flip operations. Also, we show lasing of these special states are vector beams. The order of the vector beam is given by the topological charge carried by these special modes. Using this rule, we can design lasers that are generically high-order vector beams.
Biologically Inspired Design Of Small Flapping Wing Air Vehicles Using Four-Bar Mechanisms And Quasi-steady Aerodynamics (2004)

In this paper, the energetics of a flapping wing micro air vehicle is analyzed with the objective of design of flapping wing air vehicles. The salient features of this study are: (i) design of an energy storage mechanism in the air vehicle similar to an insect thorax which stores part of the kinetic energy of the wing as elastic potential energy in the thorax during a flapping cycle; (ii) inclusion of aerodynamic wing models using blade element theory and inertia of the mechanism using rigid body modeling techniques; (iii) optimization of parameters of the energy storage mechanism using the dynamic models so that the peak power input from the external actuators during a flapping cycle is minimized. A series of engineering prototypes based on these studies have been fabricated which justify the use of these mathematical techniques.
Wavelength-Switchable Mid-Infrared Narrowband Thermal Emitters Based on Quantum Wells and Photonic Crystals (2018)

Development of narrowband thermal emitters whose emission wavelengths are dynamically tunable is highly desired for various applications including the sensing of gases and chemical compounds. In this paper, we review our recent demonstration of wavelength-switchable mid-infrared thermal emitters based on multiple quantum wells (MQWs) and photonic crystals (PCs). Through the control of absorptivity by using intersubband transitions in MQWs and optical resonances in PC slabs, we demonstrate novel control of thermal emission, including realization of high-Q (Q>100) thermal emission, dynamic control of thermal emission (∼MHz), and electrical wavelength switching of thermal emission from a single device.
Symbol-Level Precoding with Low Resolution DACs for Large-Scale Array MU-MIMO Systems (2018)

While (Multiple Input-Multiple Output) MIMO systems based on large-scale antenna arrays are seen as the solution to the continuously increasing demands in modern wireless systems, they require high hardware complexity and power consumption. To tackle this, solutions based on low resolution Analog-to-Digital Converters (ADCs) / Digital-to-Analog Converters (DACs) have been developed in the literature where they mainly propose quantized versions of typical channel dependent linear precoding solutions. Alternatively, nonlinear Symbol level Precoding techniques have been recently proposed for downlink Multi User (MU)-MIMO systems with low resolution DACs that achieve significantly improved performance in several cases. The existing SLP approaches support only DACs of 1-bit resolution which result in significant performance degradations, especially when constellations with order greater than 4 are employed. To that end, in this work a novel SLP approach is developed that supports systems with DACs of any resolution and it is applicable for any type of constellation. As it is verified by the presented numerical results, the proposed approach exhibits significantly improved performance when constellations with order greater than 4 are employed and require reduced computational complexity, compared to the existing solutions for the 1-bit DAC case.
The first example of a Robinson annulation on a carbohydrate derivative (1987)

R. V. Bonnert and P. R. Jenkins, J. Chem. Soc., Chem. Commun., 1987, 6 DOI: 10.1039/C39870000006
Bit Plane Encoding (2009)

Consider an N x N image in which each pixel value is represented by k bits. By selecting a single bit from the same position in the binary representation of each pixel, an N x N binary image called a bit plane can be formed [6]. For example, we can select the most significant bit of each pixel value to generate an N x N binary image representing the most significant bit plane. Repeating this process for the other bit positions, the original image can be decomposed into a set of k, N x N bit planes (numbered 0 for the least significant bit (LSB) plane through k â 1 for the most significant bit (MSB) plane). The motivation for this decomposition is that each bit plane can then be encoded efficiently using a lossless binary compression technique. Furthermore, in certain applications, the user may desire a low bit rate approximation to the original image before making the decision to proceed to a lossless mode. Since the more significant bit planes generally contain major structural information and are highly compressible, progressively reconstructing an image using the bit planes can be a viable technique for this purpose. This technique of progressive transmission is discussed in more detail in Chapter 14: Hierarchical Coding under Lossy Compression Techniques.
Terahertz Resonance Splitting via Mutual Coupling between Parallel-Plate Waveguide Cavities (2010)

The inclusion of multiple resonant cavities in a terahertz TE1-mode parallel-plate waveguide induces splitting of the fundamental resonance due to coupling between the cavities. The resulting features have a higher Q-value than the original resonance.
Findings of the WMT 2022 Biomedical Translation Shared Task: Monolingual Clinical Case Reports (2022)

Mariana Neves, Antonio Jimeno Yepes, Amy Siu, Roland Roller, Philippe Thomas, Maika Vicente Navarro, Lana Yeganova, Dina Wiemann, Giorgio Maria Di Nunzio, Federica Vezzani, Christel Gerardin, Rachel Bawden, Darryl Johan Estrada, Salvador Lima-lopez, Eulalia Farre-maduel, Martin Krallinger, Cristian Grozea, Aurelie Neveol. Proceedings of the Seventh Conference on Machine Translation (WMT). 2022.
From Carnegie Mellon to Berkshire Grey (2019)

When I first joined Carnegie Mellon in 1982, a mentor (Allen Newell) said that he had simplified his intellectual life by avoiding entanglements with industry. I found that idea appealing, and followed that model for over 30 years. It wasn&#x2019;t too difficult, because of my innate skepticism toward most visions of the next commercial robotics revolution. That all changed in the course of a two-hour meeting with Tom Wagner, when he laid out his vision of a robotic transformation of materials handling, and a company (Berkshire Grey) that could make it happen. Berkshire Grey emerged from stealth mode several months ago, so that I can now talk about Wagner&#x2019;s vision, Berkshire Grey&#x2019;s accomplishments, and the interaction of academia and industry.
Transient Hypoplastic Anemia Caused by Primary Human Parvovirus B19 Infection in a Previously Untreated Patient With Hemophilia Transfused With a Plasma-Derived, Monoclonal Antibody-Purified Factor VIII Concentrate (1999)

Clotting factor concentrates for the treatment of hemophilia retain a risk for HPV-B19 contamination. HPV-B19 viral infection might induce hypoplastic anemia in these patients, particularly during enhanced hemopoiesis after acute blood loss.
Fusing acridine and benzofuran/benzothiophene as a novel hybrid donor for high-performance and low efficiency roll-off TADF OLEDs (2019)

The effect on TADF character resulting from the fusing strategies of acridine and benzofuran/benzothiophene hybrid donors.
GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like (2018)

The biological functions of the dual bromodomains of human transcription-initiation-factor TFIID subunit 1 (TAF1(1,2)) remain unknown, although TAF1 has been identified as a potential target for oncology research. Here, we describe the discovery of a potent and selective in vitro tool compound for TAF1(2), starting from a previously reported lead. A cocrystal structure of lead compound 2 bound to TAF1(2) enabled structure-based design and structure–activity-relationship studies that ultimately led to our in vitro tool compound, 27 (GNE-371). Compound 27 binds TAF1(2) with an IC50 of 10 nM while maintaining excellent selectivity over other bromodomain-family members. Compound 27 is also active in a cellular-TAF1(2) target-engagement assay (IC50 = 38 nM) and exhibits antiproliferative synergy with the BET inhibitor JQ1, suggesting engagement of endogenous TAF1 by 27 and further supporting the use of 27 in mechanistic and target-validation studies.
Color image denoising and blind deconvolution using the beltrami operator (2004)

A new method for the recovery of noisy and blurred color images is presented. The image is reconstructed and the blurring kernel is approximated, under the assumption of linearity and spatial invariance of the blurring kernel. It is done by combining the Beltrami operator, which was introduced as a general framework for low-level vision, with the scheme of the blind deconvolution, which was introduced for the recovery of blurred and noisy gray value images. Consequently, image and kernel edges are preserved due to the adaptive smoothing feature of this operator. The color channels are coupled by a Riemannian structure, which is defined on the color image. The functional minimization scheme is presented and results of applying it in the recovery of blurred and noisy color images are illustrated.
Neurofibromatosis type 1: MRI findings and follow-up imaging in childhood (2013)

Poster: ECR 2013 / C-0162 / Neurofibromatosis type 1: MRI findings and follow-up imaging in childhood by: Solis Muniz, M. A. Lopez Pino, S. I. Sirvent, E. Garcia Esparza, G. Albi, G. Gomez Mardones; Madrid/ES
Shape and materials by example: a photometric stereo approach (2003)

This paper presents a technique for computing the geometry of objects with general reflectance properties from images. For surfaces with varying material properties, a full segmentation into different material types is also computed. It is assumed that the camera viewpoint is fixed, but the illumination varies over the input sequence. It is also assumed that one or more example objects with similar materials and known geometry are imaged under the same illumination conditions. Unlike most previous work in shape reconstruction, this technique can handle objects with arbitrary and spatially-varying BRDFs. Furthermore, the approach works for arbitrary distant and unknown lighting environments. Finally, almost no calibration is needed, making the approach exceptionally simple to apply.
Hybrid Teams of Humans, Robots, and Virtual Agents in a Production Setting (2016)

This video paper describes the practical outcome of the first milestone of a project aiming at setting up a so-called Hybrid Team that can accomplish a wide variety of different tasks. In general, the aim is to realize and examine the collaboration of augmented humans with autonomous robots, virtual characters and SoftBots (purely software based agents) working together in a Hybrid Team to accomplish common tasks. The accompanying video shows a customized packaging scenario and can be downloaded from http://hysociatea.dfki.de/?p=441.
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape (2016)

Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways.
Supplementary table 2 from Low Cancer Stem Cell Marker Expression and Low Hypoxia Identify Good Prognosis Subgroups in HPV(−) HNSCC after Postoperative Radiochemotherapy: A Multicenter Study of the DKTK-ROG (2023)

&lt;p&gt;Univariate analyses of both hypoxia gene signatures using nanoString or RT-PCR analyses. HR = hazard ratio; 95% CI = 95 percent confidence interval.&lt;/p&gt;
Inhibitory effect of targeted therapies of different signalling pathways in DEN-induced hepatocarcinogenesis in C57BL/6 mice (2019)

Background: We describe the successful DEN-induced hepatocarcinogenesis in C57BL/6 mice and investigate the impact of 2 different waiting periods (10 and 12 months), and targeted therapies. Methods: In 60 male mice C57BL/6 DEN-induced hepatocarcinogenesis was achieved. DEN, 5mg/kg bw, was administered intraperitoneally on their 15th day of life. We divided the 60 mice in two major categories according to the post hepatocarcinogenesis waiting periods (10 and 12 months). We then allocated 6 groups with 10 experimental subjects. Group A (10 months) control HCC group, group B (10 months) with administration of anti-Aurora Kinase (PHA-739358, Danusertib), group C (10 months) with administration of anti-WNT1, group D (12 months) control HCC, group E (12 months) with administration of anti-HDAC (Romidepsin) and group F (12 months) with administration of anti-TOPK (HI-TOPK-32). Group G served as control. All animals were sacrificed on the 10th or 12th month of their life according to the protocol. Liver, lungs and serum were retrieved for analyses. Results: Histopathology analysis showed achievement of HCC genesis in the DEN group and administration of targeted therapies intervened in the development of HCC and the cell signaling. Conclusion: DEN-induced hepatocarcinogenesis proved to develop HCC successfully in mice. Targeted therapies for HCC demonstrated an inhibitory effect in the development of HCC and intervened in the HCC development cell signaling.
TiO2-coated optical fibers for distributed pH monitoring at high pressures and temperatures (2023)

In the oil and gas, CO<sub>2</sub> sequestration, H<sub>2</sub> subsurface storage, and geothermal energy sectors, subsurface pH measurements are critical for monitoring the geochemical conditions and structural integrity of wellbore systems. Real-time pH measurements in these conditions are vital for detecting and predicting corrosion deterioration of wellbore components that may jeopardize the safety and continued operation of wellbore systems. The viability of TiO<sub>2</sub>-coated optical fibers has previously been demonstrated as an effective sensor design for continuous distributed pH monitoring at elevated temperatures and ambient pressures. However, real wellbore conditions contain high pressures and the effects of high pressures on sensor results and the sensing layer have not been well studied. As TiO<sub>2</sub> has been established in the literature as being stable at temperatures and pressures substantially higher than those expected in typical wellbore conditions, it makes for a promising sensing material for applications requiring high-pressure, high-temperature (HPHT) conditions. In this study, a sol-gel deposition method is used to coat the optical fiber sensors with TiO<sub>2</sub> sensing layer. The sensor performance was measured using optical transmission measurements at various pH and using optical backscatter reflectometry for distributed pH sensing demonstration in wellbore-relevant pressures (up to 1000 psi) and temperatures (~80 °C). The TiO<sub>2</sub> sensing layer was characterized using scanning electron microscopy (SEM) and full spectrum UV-Vis-NIR transmission data for a planar substrate. The TiO<sub>2</sub>-coated optical fiber sensor is tested for any pressure-derived effects and the viability of this sensor design for real-time in-situ wellbore pH monitoring is discussed.