gebhart/patrepeval huggingface dataset:
Threshold suprachoroidal–transretinal stimulation current resulting in retinal damage in rabbits (2007)

The purpose of this study is to determine the threshold suprachoroidal-transretinal stimulation (STS) current that results in retinal damage in rabbits. Biphasic STS pulses (anodic first, frequency 20 Hz) were used to stimulate the retina of pigmented rabbits (n = 18) continuously for 1 h using a 100 microm diameter platinum wire electrode. The STS current that induced retinal damage after 1 h was determined by ophthalmoscopy or by fluorescein angiography (FA) independently. The effect of the pulse duration on the threshold current was investigated. Histological studies were performed after electrical stimulation experiments. The threshold for a safe current to the retina was 0.6 mA for a duration of 0.5 ms. The threshold for a safe charge increased approximately linearly with an increase of stimulus duration but the threshold for a safe current decreased logarithmically with an increase of duration. The threshold for a safe electrical energy remained almost constant for all durations. Histological examination showed severe retinal damage when the current exceeded the threshold, with more damage in the inner layers compared with the outer layers of the retina. The threshold for the safe current was higher than that reported for direct stimulation of neural tissues, suggesting that the STS method was safe and able to be used with a retinal prosthesis. Because the threshold for the safe charge was lower with shorter pulse durations, care should be taken using pulses of short durations.
Dynamic Information Flow Tracking for Detection of Advanced Persistent Threats: A Stochastic Game Approach (2020)

Advanced Persistent Threats (APTs) are stealthy customized attacks by intelligent adversaries. This paper deals with the detection of APTs that infiltrate cyber systems and compromise specifically targeted data and/or infrastructures. Dynamic information flow tracking is an information trace-based detection mechanism against APTs that taints suspicious information flows in the system and generates security analysis for unauthorized use of tainted data. In this paper, we develop an analytical model for resource-efficient detection of APTs using an information flow tracking game. The game is a nonzero-sum, turn-based, stochastic game with asymmetric information as the defender cannot distinguish whether an incoming flow is malicious or benign and hence has only partial state observation. We analyze equilibrium of the game and prove that a Nash equilibrium is given by a solution to the minimum capacity cut set problem on a flow-network derived from the system, where the edge capacities are obtained from the cost of performing security analysis. Finally, we implement our algorithm on the real-world dataset for a data exfiltration attack augmented with false-negative and false-positive rates and compute an optimal defender strategy.
La méthode par changement d'échelle: un outil de conception de cellules actives de réseaux réflecteurs (2007)

International audience
“Let’s Talk about OA Pain”: A Qualitative Analysis of the Perceptions of People Suffering from OA. Towards the Development of a Specific Pain OA-Related Questionnaire, the Osteoarthritis Symptom Inventory Scale (OASIS) (2013)

Pain is the primary outcome measurement in osteoarthritis, and its assessment is mostly based on its intensity. The management of this difficult chronic condition could be improved by using pain descriptors to improve analyses of painful sensations. This should help to define subgroups of patients based on pain phenotype, for more adapted treatment. This study draws upon patients' descriptions of their pain, to identify and understand their perception of osteoarthritis pain and to categorize pain dimensions.
Constraints on the Higgs boson self-coupling from single- and double-Higgs production with the ATLAS detector using pp collisions at s=13 TeV (2023)

Constraints on the Higgs boson self-coupling are set by combining double-Higgs boson analyses in the bb¯bb¯, bb¯τ+τ− and bb¯γγ decay channels with single-Higgs boson analyses targeting the γγ, ZZ⁎, WW⁎, τ+τ− and bb¯ decay channels. The data used in these analyses were recorded by the ATLAS detector at the LHC in proton–proton collisions at s=13 TeV and correspond to an integrated luminosity of 126–139 fb−1. The combination of the double-Higgs analyses sets an upper limit of μHH<2.4 at 95% confidence level on the double-Higgs production cross-section normalised to its Standard Model prediction. Combining the single-Higgs and double-Higgs analyses, with the assumption that new physics affects only the Higgs boson self-coupling (λHHH), values outside the interval −0.4<κλ=(λHHH/λHHHSM)<6.3 are excluded at 95% confidence level. The combined single-Higgs and double-Higgs analyses provide results with fewer assumptions, by adding in the fit more coupling modifiers introduced to account for the Higgs boson interactions with the other Standard Model particles. In this relaxed scenario, the constraint becomes −1.4<κλ<6.1 at 95% CL.
A series of pyrimidine based blue to green thermally activated delayed fluorescent emitters realizing a high EQE of 25% (2016)

Here, we developed a series of pyrimidine-based TADF emitters, 2-functionalized-4,6-bis[4-(9,9-dimethyl-9,10- dihydroacridine)phenyl]pyrimidine called <strong>Ac–RPM</strong>. We introduced a phenylacridine moiety into the 4,6-position of pyrimidine core to induce a twisted structure leading to a high PLQY of ~80%, and a small singlet and triplet excited energy difference of &lt;0.20 eV. The optimized device realized a power efficiency of 62 lm W<sup>−1</sup>, a high EQE<sub>max</sub> of 25%, light-blue emissions with the Commission Internationale de l’Eclairage chromaticity (CIE) coordinates of (0.19, 0.37) and a low turn-on voltage of &lt;3.0 V. Further, we investigated the strucutre–property relationship to unlock the potential of pyrimidine-based emitter. Consequently, we developed a green emitter realizing a power efficiency of over 110 lm W<sup>−1</sup> while maintaining extremely low voltages of 2.2 V at 1 cd m<sup>−2</sup> and 3.0 V at 1000 cd m<sup>−2</sup> at CIE of (0.36, 0.58). Apparently, these performances exceed those of previous TADF devices and are comparable to those of their state-of-the-art phosphorescent devices.
Cryptococcus gattii: Emergence in Western North America: Exploitation of a Novel Ecological Niche (2009)

The relatively uncommon fungal pathogen Cryptococcus gattii recently emerged as a significant cause of cryptococcal disease in human and animals in the Pacific Northwest of North America. Although genetic studies indicated its possible presence in the Pacific Northwest for more than 30 years, C. gattii as an etiological agent was largely unknown in this region prior to 1999. The recent emergence may have been encouraged by changing conditions of climate or land use and/or host susceptibility, and predictive ecological niche modeling indicates a potentially wider spread. C. gattii can survive wide climatic variations and colonize the environment in tropical, subtropical, temperate, and dry climates. Long-term climate changes, such as the significantly elevated global temperature in the last 100 years, influence patterns of disease among plants and animals and create niche microclimates habitable by emerging pathogens. C. gattii may have exploited such a hitherto unrecognized but clement environment in the Pacific Northwest to provide a wider exposure and risk of infection to human and animal populations.
Electronic and crystal structures of Ln FeAsO 1− x H x ( Ln = La, Sm) studied by x-ray absorption spectroscopy, x-ray emission spectroscopy, and x-ray diffraction (part I: carrier-doping dependence) (2021)

A carrier doping by a hydrogen substitution in LaFeAsO<sub>1-<i>x</i></sub>H<sub><i>x</i></sub>is known to cause two superconducting (SC) domes with the magnetic order at both end sides of the doping. In contrast, SmFeAsO<sub>1-<i>x</i></sub>H<sub><i>x</i></sub>has a similar phase diagram but shows single SC dome. Here, we investigated the electronic and crystal structures for iron oxynitride<i>Ln</i>FeAsO<sub>1-<i>x</i></sub>H<sub><i>x</i></sub>(<i>Ln</i>= La, Sm) with the range of<i>x</i>= 0-0.5 by using x-ray absorption spectroscopy, x-ray emission spectroscopy, and x-ray diffraction. For both compounds, we observed that the pre-edge peaks of x-ray absorption spectra near the Fe-<i>K</i>edge were reduced in intensity on doping. The character arises from the weaker As-Fe hybridization with the longer As-Fe distance in the higher doped region. We can reproduce the spectra near the Fe-<i>K</i>edge according to the Anderson impurity model with realistic valence structures using the local-density approximation (LDA) plus dynamical mean-field theory (DMFT). For<i>Ln</i>= Sm, the integrated-absolute difference (IAD) analysis from x-ray Fe-<i>Kβ</i>emission spectra increases significantly. This is attributed to the enhancement of magnetic moment of Fe 3<i>d</i>electrons stemming from the localized picture in the higher doped region. A theoretical simulation implementing the self-consistent vertex-correction method reveals that the single dome superconducting phase for<i>Ln</i>= Sm arises from a better nesting condition in comparison with<i>Ln</i>= La.
Three-Dimensional Dynamic Self-Assembly of Spinning Magnetic Disks:  Vortex Crystals (2002)

This paper describes dynamic self-assembly of millimeter-sized, magnetized disks floating at two parallel interfaces and spinning under the influence of a rotating, external magnetic field. All disks experience a central, confining magnetic potential, and interact with one another hydrodynamically both in the plane of the interface, and between the interfaces. The interactions between the disks spinning on different interfaces are repulsive for low rotational speeds, and attractive for high rotational speeds. The interplay between magnetic and hydrodynamic forces acting in the system leads to the formation of quasi three-dimensional, ordered aggregates. Changing the rotation speeds of the disks can reversibly change the morphologies of these aggregates.
The Literary Study of Adhoshakhagat Avedhya Siras (2018)

Background- The ‘Sira’ term is used collectively for blood vessels (Arteries, Veins, Capillaries, and lymphatics) which denote the circulatory system. Some siras are not suitable for venepuncture. These siras are called Avedhya sira. A surgeon should not perform venesection on this siras whch definitely can cause disability or death. The sites are available in classic texts but the exact location and anatomical description not yet described. Therefore, it requires great research work to get a clear concept. Aim & objectives- To correlate Adhoshakhagat Avedhya Siras mentioned by our mentors with modern anatomical structures and review in contemporary science. Materials and methodology- Ancient Ayurvedic classics were reviewed and compiled references for said subject were critically studied to comprehend the Avedhya siras in lower extremities. Observations & Results – Scattered references are available in Ayurvedic classics and Modern Anatomy (surgical & clinical) texts regarding Avedhya Sira. Preliminary knowledge of Avedhya Siras is very important for Physicians as well as surgeon. The Avedhya Siras stated in Ayurveda compendia can be correlated with blood vessels, vein in Modern Anatomy.
A Logical Approach to High-Level Robot Programming A Progress Report* (1994)

This paper describes a novel approach to high-level robot programming based on a highly developed logica] theory of action. The user provides a specification of the robot’s basic actions (their preconditions and effects on the environment) as well as of relevant aspects of the environment, in an extended version of the situation calculus. He can then specify robot behaviors in terms of these actions in a programming language that allows references to world conditions (e.g. if 3c(PoP-CAN(c) A ON_TABLE(c)) then PICK_UP(c)). The programs can be executed to drive the robot. The interpreter automatically maintains the world model required to execute programs based on the specification. The theoretical framework includes a solution to the frame problem and is very general -- it handles dynamic and incompletely known worlds, as well as perception actions. Given this kind of domain specification, it is Mso possible to support more sophisticated reasoning, such as task planning at run-time. The specification can also be used to prove the robot control programs correct. A simple mall delivery application is used to present the approach. Ongoing work on implementing the approach and handling outstanding problems, such as modeling noisy sensors, is also described.
Impact of nonpenetrating clips on intimal hyperplasia of vascular anastomoses (2001)

Non-penetrating, arcuate-legged titanium clips create an interrupted, non-penetrated, yet compliant vascular anastomoses that is associated with significantly reduced anastomotic neointimal hyperplasia. Recent experimental and clinical studies provide evidence that the non-suture alternative changes the biology of vessel-to-vessel and graft-to-vessel connections that reduces the stimulus for hyperplasia at a number of critical points in the response to injury schema. The compliant, "blood-tight" characteristics of clipped vascular reconstructions are associated with no endothelial injury or intraluminal foreign body, minimal platelet aggregation and laminal flow. Clinical applications including vascular access, femoropopliteal bypass, and closure of carotid endarterectomies are remarkable for the absence of restenosis and preserved anastomotic patency.
Cell cycle specific effects of deferoxamine on human and murine hematopoietic progenitor cells. (1988)

The effect of the iron chelator deferoxamine (DSF) on the proliferation of normal erythroid and granulocyte-macrophage progenitor cells from human and murine bone marrow was examined. The addition of DSF at a concentration equivalent to the concentration of iron present in the culture system resulted in dose dependent inhibition of colony formation by human and murine granulocyte-macrophage progenitor cells and human normal erythroid progenitor cells. The addition of FeCl3 at culture initiation completely reversed the effects of DSF. Furthermore, significant numbers of progenitor cells could be rescued from the effects of DSF by iron added back as late as 24-48 h after exposure to DSF. The cell cycle specificity of DSF was also examined using bone marrow cells treated with high specific activity tritiated thymidine. Kinetic experiments demonstrated that in the presence of DSF the number of erythroid or granulocyte-macrophage colonies that could be rescued was dependent on the length of exposure to DSF. Comparisons between control and tritiated thymidine treated cells indicated that the proliferation of progenitor cells in S phase of the cell cycle was inhibited if iron was withheld until 6 and 24 h after exposure to DSF for murine and human cells, respectively, with little to no effect observed on progenitor cells not in S phase during this time period. These results confirm the importance of iron for hematopoietic progenitor cell proliferation and represent a new method by which the proliferation of cycling cells may be investigated in situ in semisolid culture systems.
Data from Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;The myotonic dystrophy–related Cdc42-binding kinases MRCKα and MRCKβ contribute to the regulation of actin–myosin cytoskeleton organization and dynamics, acting in concert with the Rho-associated coiled-coil kinases ROCK1 and ROCK2. The absence of highly potent and selective MRCK inhibitors has resulted in relatively little knowledge of the potential roles of these kinases in cancer. Here, we report the discovery of the azaindole compounds BDP8900 and BDP9066 as potent and selective MRCK inhibitors that reduce substrate phosphorylation, leading to morphologic changes in cancer cells along with inhibition of their motility and invasive character. In over 750 human cancer cell lines tested, BDP8900 and BDP9066 displayed consistent antiproliferative effects with greatest activity in hematologic cancer cells. Mass spectrometry identified MRCKα S1003 as an autophosphorylation site, enabling development of a phosphorylation-sensitive antibody tool to report on MRCKα status in tumor specimens. In a two-stage chemical carcinogenesis model of murine squamous cell carcinoma, topical treatments reduced MRCKα S1003 autophosphorylation and skin papilloma outgrowth. In parallel work, we validated a phospho-selective antibody with the capability to monitor drug pharmacodynamics. Taken together, our findings establish an important oncogenic role for MRCK in cancer, and they offer an initial preclinical proof of concept for MRCK inhibition as a valid therapeutic strategy.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Significance:&lt;/b&gt; The development of selective small-molecule inhibitors of the Cdc42-binding MRCK kinases reveals their essential roles in cancer cell viability, migration, and invasive character. &lt;i&gt;Cancer Res; 78(8); 2096–114. ©2018 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
149 Establishment of Evaluation Method for Improving Ride Quality Based on Human Dynamics (2007)

In development of automobile, improving ride quality has been strongly demanded. It is necessary to analysis and to evaluate the method of ride quality. This study aimed at estimating discomfort or comfort level by the movements of the head and the upper part of the body. We measured human sensibilities and vibration characteristics on both driver and fellow passenger under the stationary wave. As a result, it was clarified that sensibilities and vibration characteristics of fellow passenger was different from those of driver. And, the evaluating indexes of ride quality were obtained.
Induction of HIV mucosal immunity at distal sites after encapsulation of NOD1 and NOD2 ligands in biodegradable nanocarriers (2012)

Background The use of TLR ligands as mucosal adjuvant for vaccine administration is already largely described; wherease the use of NOD-like receptors ligands is still investigated. As activation of intracytoplasmic NOD like-receptors is able to induce production of pro-inflammatory molecules, we have evaluated if their co-delivery into biodegradable nanocarriers carrying HIV-Gag antigens could amplify the mucosal immune responses in mice at the vaginal and intestinal (HIV replication site)
Rapid Discrimination of Bacteria by Paper Spray Mass Spectrometry (2014)

Paper spray mass spectrometry ambient ionization is utilized for rapid discrimination of bacteria without sample preparation. Bacterial colonies were smeared onto filter paper precut to a sharp point, then wetted with solvent and held at a high potential. Charged droplets released by field emission were sucked into the mass spectrometer inlet and mass spectra were recorded. Sixteen different species representing eight different genera from Gram-positive and Gram-negative bacteria were investigated. Phospholipids were the predominant species observed in the mass spectra in both the negative and positive ion modes. Multivariate data analysis based on principal component analysis, followed by linear discriminant analysis, allowed bacterial discrimination. The lipid information in the negative ion mass spectra proved useful for species level differentiation of the investigated Gram-positive bacteria. Gram-negative bacteria were differentiated at the species level by using a numerical data fusion strategy of positive and negative ion mass spectra.
N Latex FLC – new monoclonal high-performance assays for the determination of free light chain kappa and lambda (2011)

N Latex FLC demonstrates high precision, good lot-to-lot consistency and freedom from a high-dose hook effect. The method comparison between Freelite™ and the N Latex FLC assays showed good clinical concordance. Further studies need to reveal the clinical value of the new FLC assays.
“Smart Dust”: Nanostructured Devices in a Grain of Sand (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Costimulatory effects of T cell proliferation during infection with human T lymphotropic virus types I and II are mediated through CD80 and CD86 ligands (1996)

The modulation of expression of CD80 and CD86 on T cells following infection with human T lymphotropic virus (HTLV)-I/II and its functional importance in T-T cell interactions was examined. Infection with HTLV-I/II leads to constitutive expression of CD80 and CD86, concomitant to down-modulation of CD28 on T cells. The CD80/CD86+ HTLV-infected T cells stimulated proliferation of allogeneic and autologous resting T cells, which could be specifically blocked by a soluble CTLA-4Ig chimeric protein, anti-CD80 or anti-CD86, but not by anti-CD54. It was necessary to inhibit interaction with both ligands (CD80 and CD86) to optimally block HTLV-mediated proliferation of allogeneic and autologous resting T cells. Simultaneous addition of anti-CD8O and anti-CD86 Abs also inhibited production of IFN-gamma, TNF-alpha, and IL-4, with no effect on IL-10 production, for both allo- and autologous T cell proliferation. Further, there was a direct correlation between the spontaneous proliferation of lymphocytes from patients infected with HTLV-II and expression of CD80, which could be blocked by simultaneous addition of anti-CD80 and anti-CD86. Taken together, these results suggest that HTLV-infected CD80/CD86+ T cells serve as APCs, leading to a sustained proliferation of T cells, and that both ligands participate in allostimulation, autologous proliferation, as well as spontaneous proliferation of HTLV-II-infected PBMC.
Synthesis and reactivity of bidentate phosphine iron complex [(C2F5)2PCH2CH2P(C2F5)2]Fe(CO)3 (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and reactivity of bidentate phosphine iron complex [(C2F5)2PCH2CH2P(C2F5)2]Fe(CO)3Maurice Brookhart, Wayne A. Chandler, Anne C. Pfister, Catherine C. Santini, and Peter S. WhiteCite this: Organometallics 1992, 11, 3, 1263–1274Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://pubs.acs.org/doi/10.1021/om00039a036https://doi.org/10.1021/om00039a036research-articleACS PublicationsRequest reuse permissionsArticle Views315Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts