gebhart/patrepeval huggingface dataset:
Time-Frequency Channel estimation for MB-OFDM UWB Systems (2006)

Multiband OFDM (MB-OFDM) has been envisioned for ultrawide-band (UWB) systems. In this paper we discuss the aspects of designing a channel estimator for such a system, using the Saleh-Valenzuela (S-V) channel model specified by the UWB IEEE 802.15.3a standard body. In a first step, the time-frequency correlation properties of the channel are derived based on the S-V model. In a second step we derive an iterative MMSE channel estimation algorithm, adapted for a UWB system using multiband OFDM and a channel code. The algorithm is tested using pilot-based and decision-directed iterative estimation on the four channel models specified by the IEEE 802.15.3a model. The performance of the proposed algorithm is presented with simulation of its bit error rate as well as its estimation error variance and shows a significant improvement compared with previously published UWB channel estimators
Clinical evaluation of the efficacy of a desensitizing paste containing 8% arginine and calcium carbonate for the in-office relief of dentin hypersensitivity associated with dental prophylaxis. (2009)

45 subjects completed the study. At the final hypersensitivity examinations, conducted immediately after the completion of the dental cleaning procedure, subjects assigned to the test group exhibited statistically significant improvements from baseline with respect to baseline-adjusted mean tactile (132.1%) and air blast hypersensitivity scores (48.6%). Additionally, subjects assigned to the control group exhibited a statistically significant hypersensitivity improvement from baseline with respect to baseline-adjusted mean air blast hypersensitivity scores (13.9%). The hypersensitivity improvement from baseline indicated for the control group for mean tactile hypersensitivity scores (21.7%) was not statistically significant. At the final hypersensitivity examinations, statistically significant differences were indicated between the test group and the control group with respect to baseline-adjusted mean tactile (110.0%) and air blast hypersensitivity scores (41.9%).
Effect of draw ratio on the structure of aromatic copolyimide fibers of random monomer sequence (1995)

Abstract X‐ray methods have been used to investigate the structure of fibers of aromatic copolyimides prepared from 3,3′,4,4′‐biphenyltetracarboxylic dianhydride (BPDA), o ‐tolidine (OTOL) and p ‐phenylene diamine (PPD). We have shown previously that the non‐periodic layer lines in the X‐ray fiber diagrams of these copolymers are indicative of a random comonomer sequence. In the present paper, we analyze the shifts in the layer line positions that occur with increasing draw ratio. These changes are to be understood primarily in terms of increases in the correlation lengths for the stiff chain conformation. At high draw ratios there is also evidence for the development of a more extended chain conformation, probably due to torsional variation changes in the torsion angles. It is shown that the data are sufficiently sensitive to allow quantitative analysis of these separate effects, and their dependence on comonomer ratio.
Plug‐in Hybrid Electric Vehicles (2011)

Plug-in hybrid electric vehicles (PHEV) have the potential to displace transportation fuel consumption by using grid electricity to drive the car. PHEVs can be driven initially using electric energy stored in the onboard battery, and onboard gasoline engine can extend the driving range. There are two types of PHEV: extended range electric vehicle, and blended mode PHEV. Although EREV can be driven electrically with a charged battery, the overall efficiency may prevent the vehicle to operate in pure electric mode due to the large losses associated with the battery and propulsion motor at high power demands. Hence, blended mode PHEV can reduce the overall cost and increase the battery pack energy density. Converting a HEV to a PHEV involves the replacement of the battery pack or adding an extra battery pack, as well as modifying the vehicle control. The PHEV conversion is discussed in detail. Vehicles equipped with a bidirectional charger can be integrated with the utility grid to serve as backup energy storage, help control the grid stability, etc.
Hopping transport through self-assembled molecules: transport mechanism for conduction-based chemical sensors (2005)

We have fabricated a testbed for hopping transport through a self-assembled monolayer (SAM), using a back-to-back Schottky barrier structure on semi-insulating GaAs, and various molecules were self-assembled on the testbed. The leakage current of the testbed is less than 1 nA. However, it was found that some of deposited molecules induce significant increase in conductivity, compared to predeposition current. There exist two possible conduction paths that might cause this phenomenon: 1) hopping conduction through SAM 2) surface potential change due to SAM. To verify that the hopping transport is a dominant conduction mechanism, I-V characteristics of thiophenol and octadecanethiol have been compared to investigate the effects of molecular dipole moment and /spl pi/-electrons on conductivity enhancement. In addition, the application of the testbed to a chemical sensor has been demonstrated by depositing redox molecules on the testbed.
Human napsin A: expression, immunochemical detection, and tissue localization (1999)

A novel aspartic proteinase, called napsin, has recently been found in human and mouse. Due to high similarity with cathepsin D a structural model of human napsin A could be built. Based on this model a potential epitope SFYLNRDPEEPDGGE has been identified, which was used to immunize rabbits. The resulting antibody was employed in monitoring the expression of recombinant human napsin A in HEK293 cell line. Western blot analysis confirmed the specificity of the antibody and showed that human napsin A is expressed as a single chain protein with the molecular weight of approximately 38 kDa. Immunohistochemical studies revealed high expression levels of napsin A in human kidney and lung but low expression in spleen.
Nanoparticle Properties Influence Transendothelial Migration of Monocytes (2022)

Nanoparticle-based delivery of therapeutics to the brain has had limited clinical impact due to challenges crossing the blood-brain barrier (BBB). Certain cells, such as monocytes, possess the ability to migrate across the BBB, making them attractive candidates for cell-based brain delivery strategies. In this work, we explore nanoparticle design parameters that impact both monocyte association and monocyte-mediated BBB transport. We use electrohydrodynamic jetting to prepare nanoparticles of varying sizes, compositions, and elasticity to address their impact on uptake by THP-1 monocytes and permeation across the BBB. An <i>in vitro</i> human BBB model is developed using human cerebral microvascular endothelial cells (hCMEC/D3) for the assessment of migration. We compare monocyte uptake of both polymeric and synthetic protein nanoparticles (SPNPs) of various sizes, as well as their effect on cell migration. SPNPs (human serum albumin/HSA or human transferrin/TF) are shown to promote increased monocyte-mediated transport across the BBB over polymeric nanoparticles. TF SPNPs (200 nm) associate readily, with an average uptake of 138 particles/cell. Nanoparticle loading is shown to influence the migration of THP-1 monocytes. The migration of monocytes loaded with 200 nm TF and 200 nm HSA SPNPs was 2.3-fold and 2.1-fold higher than that of an untreated control. RNA-seq analysis after TF SPNP treatment suggests that the upregulation of several migration genes may be implicated in increased monocyte migration (ex. integrin subunits α M and α L). Integrin β 2 chain combines with either integrin subunit α M chain or integrin subunit α L chain to form macrophage antigen 1 and lymphocyte function-associated antigen 1 integrins. Both products play a pivotal role in the transendothelial migration cascade. Our findings highlight the potential of SPNPs as drug and/or gene delivery platforms for monocyte-mediated BBB transport, especially where conventional polymer nanoparticles are ineffective or otherwise not desirable.
Time-Frequency Analysis of EEG Asymmetry Using Bivariate Empirical Mode Decomposition (2011)

A novel method is introduced to determine asymmetry, the lateralization of brain activity, using extension of the algorithm empirical mode decomposition (EMD). The localized and adaptive nature of EMD make it highly suitable for estimating amplitude information across frequency for nonlinear and nonstationary data. Analysis illustrates how bivariate extension of EMD (BEMD) facilitates enhanced spectrum estimation for multichannel recordings that contain similar signal components, a realistic assumption in electroencephalography (EEG). It is shown how this property can be used to obtain a more accurate estimate of the marginalized spectrum, critical for the localized calculation of amplitude asymmetry in frequency. Simulations on synthetic data sets and feature estimation for a brain-computer interface (BCI) application are used to validate the proposed asymmetry estimation methodology.
Effect of Muscle Strength by Trichinella spiralis Infection during Chronic Phase (2018)

<b>Introduction:</b><i>Trichinella spiralis</i> establishes a chronic infection in skeletal muscle by developing nurse cells within muscle fibers. During symbiosis in host, changes in the muscle fibers and inflammation may affect muscle function. <b>Methods</b>: We investigated muscle strength and inflammation in <i>T. spiralis-</i>infected mice during 1 to 48 weeks after infection. <b>Results</b>: Muscle strength decreased compared to that in uninfected control mice during the late infection stage. Additionally, inflammatory related cytokines increased significantly during early stage of infection and then rapidly decreased. In pathological study, nuclear infiltration maintained from the early infection stage to chronic infection stage. Moreover, vacuoles and eosinophil infiltration were observed in infected muscle in chronic stage. <b>Conclusion</b>: These results suggest that infection by <i>T. spiralis</i> significantly affects muscle function was continuously being weakness because vacuoles formation and maintained nucleus and eosinophil infiltration during chronic phase of <i>T. spiralis</i> infection.
A Collocated Finite Volume Scheme for High-Performance Simulation of Induced Seismicity in Geo-Energy Applications (2021)

Abstract We develop a collocated Finite Volume Method (FVM) to study induced seismicity as a result of pore pressure fluctuations. A discrete system is obtained based on a fully-implicit coupled description of flow, elastic deformation, and contact mechanics at fault surfaces on a fully unstructured mesh. The cell-centered collocated scheme leads to convenient integration of the different physical equations, as the unknowns share the same discrete locations on the mesh. Additionally, a multi-point flux approximation is formulated in a general procedure to treat heterogeneity, anisotropy, and cross-derivative terms for both flow and mechanics equations. The resulting system, though flexible and accurate, can lead to excessive computational costs for field-relevant applications. To resolve this limitation, a scalable parallel solution algorithm is developed and presented. Several proof-of-concept numerical tests, including benchmark studies with analytical solutions, are investigated. It is found that the presented method is indeed accurate, stable and efficient; and as such promising for accurate and efficient simulation of induced seismicity.
Improving Zernike Moments Comparison for Optimal Similarity and Rotation Angle Retrieval (2009)

Zernike moments constitute a powerful shape descriptor in terms of robustness and description capability. However the classical way of comparing two Zernike descriptors only takes into account the magnitude of the moments and loses the phase information. The novelty of our approach is to take advantage of the phase information in the comparison process while still preserving the invariance to rotation. This new Zernike comparator provides a more accurate similarity measure together with the optimal rotation angle between the patterns, while keeping the same complexity as the classical approach. This angle information is particularly of interest for many applications, including 3D scene understanding through images. Experiments demonstrate that our comparator outperforms the classical one in terms of similarity measure. In particular the robustness of the retrieval against noise and geometric deformation is greatly improved. Moreover, the rotation angle estimation is also more accurate than state-of-the-art algorithms.
Abstract 5493: Activity of RP12146, a novel, selective, and potent small molecule inhibitor of PARP 1/2, in solid tumors (2022)

Abstract Introduction: The Poly (ADP-ribose) polymerase (PARP) family plays an important role in the regulation of transcription, apoptosis and DNA damage response. Several PARP inhibitors have been approved for the treatment of BRCA-mutated ovarian, breast and pancreatic cancer. Through ‘synthetic lethality’, the applicability PARP inhibitors can be expanded to cancers beyond the well-defined BRCA defects either as monotherapy or in combination with established therapy across various solid tumor types. Herein, we describe the efficacy of RP12146 as a single agent and in combination with approved therapies in preclinical models of solid tumors. Methods: Enzymatic potency was evaluated using a PARP Chemiluminescent Activity Assay Kit (BPS biosciences). Cell growth was determined following incubation with RP12146 as a single agent or in combination with approved agents in various solid tumor cell lines. Apoptosis was evaluated following incubation of cell lines with compound for 48 or 72 h, subsequent staining with Annexin-V-PE and 7-AAD, and analysis by flow cytometry. Anti-tumor potential of RP12146 as a single agent or in combination with chemotherapeutic agents was tested in OVCAR-3 and NCI-H69 Xenografts. Expression of downstream PAR, PARP-trapping, and cleaved PARP expression were determined in cell lines and xenograft tumor samples by Western blotting. Plasma and tumor concentration of RP12146 in NCI-H69 xenograft samples were also determined. Results: RP12146 demonstrated equipotent inhibition of PARP1 (0.6 nM) and PARP2 (0.5 nM) with several fold selectivity over the other members of the PARP family. Compound caused a dose-dependent growth inhibition of both BRCA mutant and non-mutant cancer cell lines with GI50 in the range of 0.04 µM to 9.6 µM. Combination of RP12146 with Temozolomide, Topotecan, Lurbinectedin, and Abemaciclib demonstrated either additive or synergistic effects manifested by an inhibition in growth of solid tumor cell lines. RP12146 exhibited anti-tumor potential with TGI of 28% and 21.8% as a single agent in OVCAR-3 and NCI-H69 Xenograft model respectively. In NCI-H69 xenograft model, RP12146 in combination with cisplatin exhibited TGI of 69.3 %. Conclusion: Data demonstrate the therapeutic potential of RP12146 as single agent and in combination in solid tumors. RP12146 is currently being evaluated in Phase 1 clinical trials in patients with locally advanced or metastatic solid tumors (NCT05002868). Citation Format: Srikant Viswanadha, Satyanarayana Eleswarapu, Kondababu Rasamsetti, Haritha Polimati, Sridhar Veeraraghavan, Swaroop Vakkalanka. Activity of RP12146, a novel, selective, and potent small molecule inhibitor of PARP 1/2, in solid tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5493.
Multiuser separation and performance analysis of millimeter wave channels with linear precoding (2016)

In the conventional multiuser MIMO systems, user selection and scheduling has previously been used as an effective way to increase the sum rate performance of the system. However, the recent concepts of the massive MIMO systems (at centimeter wavelength frequencies) have shown that with higher spatial resolution of antenna arrays different users in the dense scenarios can be spatially separated. This in turn significantly reduces the signal processing efforts required for multiuser selection algorithms. On the other hand, recent measurements at millimeter wave frequencies show that multipath components only arrive from few angular directions leading to high spatial correlation between the paths and co-located users. This paper focus at the investigation of spatial separation among the users at the millimeter wave frequencies with fully digital linear zero-forcing transmit precoding considering various channel propagation parameters. Our analysis results convincingly give a proof that multiuser selection algorithms are still important for millimeter wave communication systems. Results also show that increased number of antenna elements does not give a major benefit to sum rate improvements as compared to the selection of correct number of users to be selected/scheduled.
Search for supersymmetry in events with photons and low missing transverse energy in pp collisions at s=7 TeV (2012)

Many models of new physics, including versions of supersymmetry (SUSY), predict production of events with low missing transverse energy, electroweak gauge bosons, and many energetic final-state particles. The stealth SUSY model yields this signature while conserving R-parity by means of a new hidden sector in which SUSY is approximately conserved. The results of a general search for new physics, with no requirement on missing transverse energy, in events with two photons and four or more hadronic jets are reported. The study is based on a sample of proton–proton collisions at s=7TeV corresponding to 4.96fb−1 of integrated luminosity collected with the CMS detector in 2011. Based on good agreement between the data and the standard model expectation, the data are used to determine model-independent cross-section limits and a limit on the squark mass in the framework of stealth SUSY. With this first study of its kind, squark masses less than 1430 GeV are excluded at the 95% confidence level.
ChemInform Abstract: Photoelectrochemical Etching of GaSb. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Compressed Text Indexes:From Theory to Practice! (2007)

A compressed full-text self-index represents a text in a compressed form and still answers queries efficiently. This technology represents a breakthrough over the text indexing techniques of the previous decade, whose indexes required several times the size of the text. Although it is relatively new, this technology has matured up to a point where theoretical research is giving way to practical developments. Nonetheless this requires significant programming skills, a deep engineering effort, and a strong algorithmic background to dig into the research results. To date only isolated implementations and focused comparisons of compressed indexes have been reported, and they missed a common API, which prevented their re-use or deployment within other applications. The goal of this paper is to fill this gap. First, we present the existing implementations of compressed indexes from a practitioner's point of view. Second, we introduce the Pizza&amp;Chili site, which offers tuned implementations and a standardized API for the most successful compressed full-text self-indexes, together with effective testbeds and scripts for their automatic validation and test. Third, we show the results of our extensive experiments on these codes with the aim of demonstrating the practical relevance of this novel and exciting technology.
Nonpeptide Arginine Vasopressin Antagonists for Both V1A and V2 Receptors: Synthesis and Pharmacological Properties of 4'-(1,4,5,6-Tetrahydroimidazo[4,5-d][1]benzoazepine-6-carbonyl)benzanilide Derivatives and 4'-(5,6-Dihydro-4H-thiazolo[5,4-d][1]benzoazepine-6-carbonyl)benzanilide Derivatives. (2000)

Arginine vasopressin (AVP) has a dual action mainly in the periphery, i.e., vasoconstriction and water reabsorption via V1A and V2 receptors; it may play a role in a number of diseases, including congestive heart failure (CHF), hypertension, renal disease, edema, and hyponatremia. We have attempted to develop a new series of orally active AVP antagonists for both V1A and V2 receptors based on the hypothesis that the blockade of both V1A and V2 receptors might be beneficial to CHF patients. In this report, a series of compounds structurally related to 4'-(1,4,5,6-tetrahydroimidazo[4,5-d][1]benzoazepine-6- carbonyl)benzanilide and 4'-(5,6-dihydro-4H- thiazolo[5,4-d][1]benzoazepine-6-carbonyl)benzanilide were synthesized and examined for AVP antagonist activity for both V1A and V2 receptors. As a result, it was found that the 4'-(1,4,5,6-tetrahydroimidazo[4,5-d][1]benzoazepine-6-carbon yl)-2- phenylbenzanilide derivatives showed potent binding affinity for both V1A and V2 receptors. Especially, 4'-(2-methyl-1,4,5,6- tetrahydroimidazo[4,5-d][1]benzoazepine-6-carbonyl)-2-phe nylbenzanilide monohydrochloride (18, YM087 = conivaptan hydrochloride) exhibited potent binding affinity and AVP antagonist activity, after intravenous administration, for both V1A and V2 receptors. Furthermore, YM087 exhibited the most potent oral activity for the V2 receptor. Details of the synthesis and pharmacological properties of this series are presented.
Isolated masseter cysticercosis in a healthy woman (2015)

We report a rare case of unilateral masseter muscle swelling in a 44-year-old female patient who was provisionally diagnosed as cysticercosis of master muscle on ultrasonography and magnetic resonance imaging. Intraoral excision of the cyst and histopathological examination confirm the mass as masseter cysticercosis.
Design, Fabrication, And Metrology Of Negative Branch Waxicons (1982)

Three negative branch waxicons, all with magnifications of 1.875, were fabricated by diamond turning at the Oak Ridge Y-12 Plant, operated for the Department of Energy by Union Carbide Corporation, Nuclear Division. One of the waxicons was a simple beam compactor, and the other two had varying degrees of ray redistribution designed into the surface profiles. I nterferometric data taken during the fabrication process were used to make tool offset position corrections between successive cuts. The final surface was tested by single-and double-pass interferometry. The intensity redistribution effect was mea-sured by using a collimated beam incident on the annular leg and scanning the intensity of the compacted beam. All three waxicons were intended for use in a HSURIA (half-symmetric unstable resonator with internal axicon) confiauration.
Sequential Batch Assembly of 3-D Microstructures by using a Magnetic Anisotropy and a Magnetic Field (2003)

This paper describes three-dimensional (3-D) microstructure assembly using an external magnetic field. An external magnetic field perpendicular to a substrate lifts a hinged structure by the torque due to the shape magnetic anisotropy. We made micro flap structures (4.5 µm-thick electroplated Permalloy) which have 0.2 µm-thick nickel elastic hinges in various size, and made lift the structures in a magnetic field up to 50 kA/m. We demonstrated that the non-dimensional factor depending on the volume of magnetic material and the stiffness of the hinges determine the sensitivity to the magnetic field. As a result, we realized sequential batch assembly using the difference of the sensitivity. The each two plates 600 µm × 600 µm in size were lifted sequentially, and out-of-plane microstructures were assembled. And the complex out-of-plan microstructures, the regular tetrahedrons 800 µm on a side with a closed linkage were able to assemble by our method.