gebhart/patrepeval huggingface dataset:
Hemodilution as a Method to Reduce Transfusion Requirements in Adolescent Spine Fusion Surgery (1999)

Hemodilution was safely used as a method to satisfy the perioperative transfusion requirements of adolescents undergoing extensive spinal surgery. By allowing patients to arrive at surgery with a higher preoperative hemoglobin and hematocrit, and by decreasing the quantity of predonated autologous blood-collected and therefore used, the hemodilution method may indirectly decrease the quantity of postoperative autologous transfusions in this population. Cell saver was not shown to be effective, and its selective use is recommended.
Double-Sided Microchannel Cooling of a Power Electronics Module Using Power Overlay (2009)

In the continuing effort to alleviate the increasing thermal loads for power electronics devices, numerous aggressive solutions have been developed, such as small-scale micro-channel heat exchangers. Although these methods can improve overall surface heat transfer to the order of 500 W cm−2, they are limited to single-sided cooling due to the typical wire-bonded electrical connections of the devices. Power overlay (POL) technology provides a stable planar structure for electrical connection, as well as attachment of an additional top-side heat exchanger. This study presents an analysis of double-sided microchannel cooling of a power electronics module. Two optimized, integral micro-channel heat sinks were attached above and below silicon power devices, with more traditional attachment on one side and a POL interface on the other. A compliant TIM was selected for low thermal resistance and good mechanical response, which allowed top-side connection to the POL surface. A theoretical model is presented that predicts the benefit of double-sided cooling based on the known performance of a single-sided heat sink and given addition thermal contact resistance for the top side. For microchannels with water, an enhancement of 26% was predicted. An experiment was also carried out to measure the actual performance benefit seen with double-sided cooling. An enhancement of over 30% was measured for a particular design. As the theory predicts, the benefit of double-sided cooling is limited for high performance designs. However, double-sided cooling could lead to high levels of thermal performance using low-performance technology.
BAM15 treats mouse sepsis and kidney injury, linking mortality, mitochondrial DNA, tubule damage, and neutrophils (2023)

Sepsis pathogenesis is complex and heterogeneous; hence, a precision-medicine strategy is needed. Acute kidney injury (AKI) following sepsis portends higher mortality. Overproduction of mitochondrial ROS (mtROS) is a potential mediator of sepsis and sepsis-induced AKI. BAM15, a chemical uncoupler, dissipates mitochondrial proton gradients without generating mtROS. We injected BAM15 into mice at 0, 6, or 12 hours after cecal ligation and puncture (CLP), and these mice were treated with fluids and antibiotics. BAM15 reduced mortality, even after 12 hours, when mice were ill, and BAM15 reduced kidney damage and splenic apoptosis. Serial plasma and urinary mitochondrial DNA (mtDNA) levels increased after CLP and decreased after BAM15 administration (at 0 or 6 hours). In vitro septic serum proportionately increased mtROS overproduction and mtDNA release from kidney tubule cells, which BAM15 prevented. BAM15 decreased neutrophil apoptosis and mtDNA release; neutrophil depletion counteracted BAM15 benefits. Further, mtDNA injection in vivo replicated inflammation and kidney injury, which was prevented by BAM15. A large dose of exogenous mtDNA reversed protection by BAM15. We conclude that BAM15 is an effective preventive and therapeutic candidate in experimental sepsis and that BAM15 and mtDNA, a potential drug-companion diagnostic/drug-efficacy pair for clinical sepsis, are mechanistically linked via mtROS.
Wide temperature range kinetics of the gas-phase reactions of chloroborane (BCl) with sulfur dioxide, nitrous oxide, oxygen, and carbon dioxide (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTWide temperature range kinetics of the gas-phase reactions of chloroborane (BCl) with sulfur dioxide, nitrous oxide, oxygen, and carbon dioxidePeter M. Futerko, Aleksandar G. Slavejkov, and Arthur FontijnCite this: J. Phys. Chem. 1993, 97, 46, 11950–11955Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/j100148a017https://doi.org/10.1021/j100148a017research-articleACS PublicationsRequest reuse permissionsArticle Views22Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Comments on the Article “On Evaluating Molecular-Docking Methods for Pose Prediction and Enrichment Factors” (2007)

The recent article "On Evaluating Molecular-Docking Methods for Pose Prediction and Enrichment Factors" (Chen H. et al. J. Chem. Inf. Model. 2006, 46, 401-415) contains a series of comments on a similar study we published in Proteins in 2004 (Perola et al. Proteins 2004, 56, 235-249). We believe that some of these comments are misleading, and we feel that an adequate response is in order.
Dynamic enforcement of knowledge-based security policies using probabilistic abstract interpretation (2013)

This paper explores the idea of knowledge-based security policies, which are used to decide whether to answer queries over secret data based on an estimation of the querier's (possibly increased) knowledge given the results. Limiting knowledge is the goal of existing information release policies that employ mechanisms such as noising, anonymization, and redaction. Knowledge-based policies are more general: they increase flexibility by not fixing the means to restrict information flow. We enforce a knowledge-based policy by explicitly tracking a model of a querier's belief about secret data, represented as a probability distribution, and denying any query that could increase knowledge above a given threshold. We implement query analysis and belief tracking via abstract interpretation, which allows us to trade off precision and performance through the use of abstraction. We have developed an approach to augment standard abstract domains to include probabilities, and thus define distributions. We focus on developing probabilistic polyhedra in particular, to support numeric programs. While probabilistic abstract interpretation has been considered before, our domain is the first whose design supports sound conditioning, which is required to ensure that estimates of a querier's knowledge are accurate. Experiments with our implementation show that several useful queries can be handled efficiently, particularly compared to exact (i.e., sound) inference involving sampling. We also show that, for our benchmarks, restricting constraints to octagons or intervals, rather than full polyhedra, can dramatically improve performance while incurring little to no loss in precision.
A DROSOPHILA MELANOGASTER Strain From Sub-Equatorial Africa Has Exceptional Thermotolerance But Decreased Hsp70 Expression (2001)

Drosophila melanogaster collected in sub-equatorial Africa in the 1970s are remarkably tolerant of sustained laboratory culture above 30 degrees C and of acute exposure to much warmer temperatures. Inducible thermotolerance of high temperatures, which in Drosophila melanogaster is due in part to the inducible molecular chaperone Hsp70, is only modest in this strain. Expression of Hsp70 protein and hsp70 mRNA is likewise reduced and has slower kinetics in this strain (T) than in a standard wild-type strain (Oregon R). These strains also differed in constitutive and heat-inducible levels of other molecular chaperones. The lower Hsp70 expression in the T strain apparently has no basis in the activation of the heat-shock transcription factor HSF, which is similar in T and Oregon R flies. Rather, the reduced expression may stem from insertion of two transposable elements, H.M.S. Beagle in the intergenic region of the 87A7 hsp70 gene cluster and Jockey in the hsp70Ba gene promoter. We hypothesize that the reduced Hsp70 expression in a Drosophila melanogaster strain living chronically at intermediate temperatures may represent an evolved suppression of the deleterious phenotypes of Hsp70.
Frequency-Domain Adaptive Algorithm for Network Echo Cancellation in VoIP (2008)

<p/> We propose a new low complexity, low delay, and fast converging frequency-domain adaptive algorithm for network echo cancellation in VoIP exploiting MMax and sparse partial (SP) tap-selection criteria in the frequency domain. We incorporate these tap-selection techniques into the multidelay filtering (MDF) algorithm in order to mitigate the delay inherent in frequency-domain algorithms. We illustrate two such approaches and discuss their tradeoff between convergence performance and computational complexity. Simulation results show an improvement in convergence rate for the proposed algorithm over MDF and significantly reduced complexity. The proposed algorithm achieves a convergence performance close to that of the recently proposed, but substantially more complex improved proportionate MDF (IPMDF) algorithm.
Enzyme‐free cell detachment mediated by resonance vibration with temperature modulation (2017)

Cell detachment is an essential process in adherent cell culture. However, trypsinization, which is the most popular detachment technique used in culture, damages cellular membranes. Reducing cellular membrane damage during detachment should improve the quality of cell culture. In this article, we propose an enzyme-free cell detachment method based on resonance vibration with temperature modulation. We developed a culture device that can excite a resonance vibration and control temperature. We then evaluated the cell detachment ratio and the growth response, observed the morphology, and analyzed the cellular protein of the collected cells-mouse myoblast cell line (C2C12). With the temperature of 10°C and the maximum vibration amplitude of 2 μm, 77.9% of cells in number were successfully detached compared with traditional trypsinization. The 72-h proliferation ratio of the reseeded cells was similar to that with trypsinization, whereas the proliferation ratio of proposed method was 12.6% greater than that of trypsinization after freezing and thawing. Moreover, the cells can be collected relatively intact and both intracellular and cell surface proteins in the proposed method were less damaged than in trypsinization. These results show that this method has definite advantages over trypsinization, which indicates that it could be applied to subcultures of cells that are more susceptible to trypsin damage for mass culture of sustainable clinical use. Biotechnol. Bioeng. 2017;114: 2279-2288. © 2017 Wiley Periodicals, Inc.
General Synthesis of α-Acetoxy Ethers from Esters by DIBALH Reduction and Acetylation (1996)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTGeneral Synthesis of α-Acetoxy Ethers from Esters by DIBALH Reduction and AcetylationVilas H. Dahanukar and Scott D. RychnovskyView Author Information Department of Chemistry, University of California, Irvine, California 92717-2025 Cite this: J. Org. Chem. 1996, 61, 23, 8317–8320Publication Date (Web):November 15, 1996Publication History Received25 June 1996Published online15 November 1996Published inissue 15 November 1996https://pubs.acs.org/doi/10.1021/jo961205mhttps://doi.org/10.1021/jo961205mbrief-reportACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views1992Altmetric-Citations151LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Ethers,Lipids,Mixtures,Organic compounds,Redox reactions Get e-Alerts
Biased reconstruction for JPEG decoding (1999)

Assuming a Laplacian distribution, there exists a well known method for optimally biasing the reconstruction levels for the quantized ac discrete cosine transform (DCT) coefficients in the JPEG decoder. This, however, requires an estimate of the Laplacian distribution parameter. We derive a new, maximum likelihood estimate of the Laplacian parameter using only the quantized coefficients available at the decoder. We quantify the benefits of biased reconstruction through extensive simulations and demonstrate that such improvements are very close to the best possible resulting from centroid reconstruction.
NCCN Guidelines Insights: Kidney Cancer, Version 2.2020 (2019)

The NCCN Guidelines for Kidney Cancer provide multidisciplinary recommendations for the clinical management of patients with clear cell and non-clear cell renal cell carcinoma, and are intended to assist with clinical decision-making. These NCCN Guidelines Insights summarize the NCCN Kidney Cancer Panel discussions for the 2020 update to the guidelines regarding initial management and first-line systemic therapy options for patients with advanced clear cell renal cell carcinoma.
The Dextranase of Lipomyces Starkeyi and Its Use in Sugar Cane Processing. (1988)

Dextranase is an enzyme which destroys dextran, a contaminant in sugar and a main constituent of dental plaque. Dextranase utilization can solve a major economic problem in the sugar industry, and in dental preparations it can keep teeth essentially free of plaque. The dextranase from the yeast Lipomyces starkeyi was investigated because this organism has been used in food related processes. This attribute should allow for Food and Drug Administration (FDA) approval for use of a Lipomyces dextranase. None of the existing commercial dextranase preparations have FDA approval. L. starkeyi was found to produce maximum amounts of dextranase when grown in a minimal medium at pH 3.0. A derepressed mutant was selected and the optimum conditions for induction of dextranase production were determined. $\beta$-Methyl-glucopyranoside was found to be a gratuitous inducer of dextranase synthesis. A fermentation system was scaled up to pilot scale and the enzyme was purified and characterized with respect to both its physical and kinetic parameters. The dextranase produced by L. starkeyi was found to be catalytically similar to the dextranases from Penicillium and Chaetomium. Dextranase from L. starkeyi was used to treat stale cane juice. A 76% reduction in dextran content, by the Haze method, was seen in the final sugar product.
Evaluation of a Sexual Abuse Prevention Workshop in a Multicultural, Impoverished Urban Area (2012)

Participants in the ESPACE sexual abuse prevention workshop were in grades 1 through 4 and attended three Montreal, Canada, public schools in low socioeconomic areas. The sample was culturally diverse, with half born outside of Canada. An evaluation was conducted to explore the effects associated with participating in the workshop and the effects of booster sessions conducted two years later. Outcomes included knowledge gained, the ability to offer behavioral responses to abusive situations, peer victimization, sense of safety, empathy, self-efficacy, and support. Results revealed that participants in this sample obtained low scores on measures of sexual abuse knowledge and that short booster sessions that elicit children's recall of the learned material might produce greater improvements.
CCDC 247063: Experimental Crystal Structure Determination (2006)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Self-similar photonic crystal cavity with ultrasmall mode volume for single-photon nonlinearities (2017)

We propose a photonic crystal cavity design with self-similar structure to achieve ultrasmall mode volume. We describe the concept with a silicon-air nanobeam cavity at λ ∼ 1550nm, reaching a mode volume of ∼7.01 × 10−5λ3.
Robust and stretchable indium gallium zinc oxide-based electronic textiles formed by cilia-assisted transfer printing (2016)

Electronic textile (e-textile) allows for high-end wearable electronic devices that provide easy access for carrying, handling and using. However, the related technology does not seem to be mature because the woven fabric hampers not only the device fabrication process directly on the complex surface but also the transfer printing of ultrathin planar electronic devices. Here we report an indirect method that enables conformal wrapping of surface with arbitrary yet complex shapes. Artificial cilia are introduced in the periphery of electronic devices as adhesive elements. The cilia also play an important role in confining a small amount of glue and damping mechanical stress to maintain robust electronic performance under mechanical deformation. The example of electronic applications depicts the feasibility of cilia for 'stick-&-play' systems, which provide electronic functions by transfer printing on unconventional complex surfaces.
Charge Density and pH Effects on Polycation Adsorption on Poly-Si, SiO2, and Si3N4Films and Impact on Removal During Chemical Mechanical Polishing (2011)

The pH-dependent interactions of five aqueous abrasive-free polycationic solutions, all at a concentration of 250 ppm, with poly-Si, SiO(2), and Si(3)N(4) films and IC1000 polishing pads used in chemical mechanical polishing have been investigated and compared with the interaction of poly(diallyldimethyl ammonium chloride) (PDADMAC) that was investigated recently. Three of the polycationic solutions, poly(dimethylamine-co-epichlorohydrin-co-ethylenediamine), poly(allylamine), and poly(ethylene imine) (PEI) enhance poly-Si removal rates (RRs) to the range of about 500 to 600 nm/min at pH 10. In contrast, poly(acrylamide) (PAA) suppressed poly-Si RRs to about 50 nm/min, whereas with a copolymer of PAA and PDADMAC, the RRs were lower than those obtained with PDADMAC but higher than those obtained with PAA. For all the polycationic solutions, the RRs of both SiO(2), and Si(3)N(4) films were ~0 nm/min. These solutions offer a low-defect option for the processing of emerging FinFET devices. The variation in the RR magnitude and dependence on pH among the different polycations is related to the relative charge density of the polycations as well as the films being polished, consistent with ζ potential data. Based on the ζ potential data and earlier published reports, it is suggested that the strong polycation-mediated bridging interactions between the polarized and weakened Si-Si bonds of the poly-Si surface and the polyurethane IC 1000 pad are responsible for the high poly-Si RRs.
Quantifying Residual HIV-1 Replication in Patients Receiving Combination Antiretroviral Therapy (1999)

These findings suggest that combination antiretroviral regimens suppress HIV-1 replication in some but not all patients. Given the half-life of latently infected CD4 lymphocytes of about six months, it may require many years of effective antiretroviral treatment to eliminate this reservoir of HIV-1.
Simultaneous distillation-extraction: preparative recovery of volatiles under mild conditions in batch or continuous operations (1998)

In a previous publication, a preparative apparatus was developed and optimized for simultaneous distillation–extraction (SDE) based on a theoretical model. In this paper, its performances were tested under various working conditions using a model mixture of flavourings. Separations were achieved at boiling water temperature as well as under mild conditions, which reduce artefact formation (room temperature, reduced pressure). High recoveries were obtained for batch experiments, but the boiler can also be fed from an external tank for continuous operations. This permits consideration of the preparative isolation of volatiles on a laboratory scale for subsequent fractionation and analysis, as well as industrial scale operations. Examples are given for real food flavours: one-step preparation and isolation of a reaction flavour, isolation of yoghurt and coffee flavourings, recovery of natural benzaldehyde from wastewater. In addition, the use of a food-grade solvent to achieve SDE isolation yields an ‘edible’ extract which can be reincorporated into a food without elimination of the solvent. Copyright © 1998 John Wiley & Sons, Ltd.
High energy ultrafast laser surface texturing with variable multi-spot patterns (2023)

We report on the efficient use of high-energy, multi-millijoule ultrafast laser sources to operate well-known low-energy micro-machining applications such as surface texturing of transparent materials. A sophisticated optical system that employs micro-lens arrays is used enabling flexible beam splitting and thus parallel processing. Here, the number of foci can be varied ranging from a few ten up to a few hundred spots. As selected examples we will present efficient glass surface texturing using 8mJ and 200W of an industry grade ultrafast laser platform. Our micro-lens-array-based optical head is generating high-quality dimples on a (100 x 100)mm2 with filling factors above 25% area in less than 15s.