gebhart/patrepeval huggingface dataset:
Fractionation of the Protein Components of Human Erythrocyte Membranes (1969)

The proteins of the human erythrocyte membrane can be fractionated into several groups. Approximately one-half of the proteins in the membrane can be removed by sequential extraction of the erythrocyte ghost, first with a solution containing chelating agents, and then with concentrated NaCl solutions. A small amount of the membrane proteins (less than 10% of the total proteins) remains in the organic phase during alcohol-ether and ether extraction of the partially fractionated membrane. The remaining membrane proteins can be solubilized in solutions of sodium dodecyl sulfate and fractionated by gel filtration into distinct groups. The amino acid and carbohydrate compositions of the eight fractions thus obtained are presented. Four of the protein fractions have large amounts of sialic acid. Several fractions contain a much greater proportion of nonpolar amino acids than does the membrane as a whole. The number of individual components in each of the fractions has been studied by acrylamide gel electrophoresis and NH2-terminal amino acid analysis. There are at least 12 different membrane proteins present in significant amounts. The size of the membrane proteins varies from about 10,000 to 150,000 in molecular weight.
Improved Search forνμ→νeOscillation in a Long-Baseline Accelerator Experiment (2006)

We performed an improved search for nu(mu) --> nu(e) oscillation with the KEK to Kamioka (K2K) long-baseline neutrino oscillation experiment, using the full data sample of 9.2 x 10(19) protons on target. No evidence for a nu(e) appearance signal was found, and we set bounds on the nu(mu) --> nu(e) oscillation parameters. At Deltam(2)=2.8 x 10(-3) eV(2), the best-fit value of the K2Knu(mu) disappearance analysis, we set an upper limit of sin(2)2theta(mue) < 0.13 at a 90% confidence level.
Reinforcement Effects from Nanodiamond in Cellulose Nanofibril Films (2018)

Although research on nanopaper structures from cellulose nanofibrils (CNFs) is well established, the mechanical behavior is not well understood, especially not when CNF is combined with hard nanoparticles. Cationic CNF (Q-CNF) was prepared and successfully decorated by anionic nanodiamond (ND) nanoparticles in hydrocolloidal form. The Q-CNF/ND nanocomposites were filtered from a hydrocolloid and dried. Unlike many other carbon nanocomposites, the Q-CNF/ND nanocomposites were optically transparent. Reinforcement effects from the nanodiamond were remarkable, such as Young's modulus (9.8 → 16.6 GPa) and tensile strength (209.5 → 277.5 MPa) at a content of only 1.9% v/v of ND, and the reinforcement mechanisms are discussed. Strong effects on CNF network deformation mechanisms were revealed by loading-unloading experiments. Scratch hardness also increased strongly with increased addition of ND.
Meals, Mindfulness, & Moving Forward: A feasibility study to a multi‐modal lifestyle approach in early psychosis (2018)

This pilot study showed that young people involved in a community early intervention program adhered to an activity-based lifestyle program which included mindfulness meditation, yoga and nutrition education, warranting further evaluation with a larger sample size.
ChemInform Abstract: Lipase‐Mediated Acylation of Acyclonucleosides. Application to Novel Fluoroquinolone Derivatives. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Simulating the human colorectal cancer microenvironment in 3D tumor-stroma co-cultures in vitro and in vivo (2020)

The tumor microenvironment (TME) plays a significant role in cancer progression and thus modeling it will advance our understanding of cancer growth dynamics and response to therapies. Most in vitro models are not exposed to intact body physiology, and at the same time, fail to recapitulate the extensive features of the tumor stroma. Conversely, animal models do not accurately capture the human tumor architecture. We address these deficiencies with biofabricated colorectal cancer (CRC) tissue equivalents, which are built to replicate architectural features of biopsied CRC tissue. Our data shows that tumor-stroma co-cultures consisting of aligned extracellular matrix (ECM) fibers and ordered micro-architecture induced an epithelial phenotype in CRC cells while disordered ECM drove a mesenchymal phenotype, similar to well and poorly differentiated tumors, respectively. Importantly, co-cultures studied in vitro, and upon implantation in mice, revealed similar tumor growth dynamics and retention of architectural features for 28 days. Altogether, these results are the first demonstration of replicating human tumor ECM architecture in ex vivo and in vivo cultures.
Impact of microcystin containing diets on physiological performance of Nile tilapia (Oreochromis niloticus) concerning stress and growth (2009)

Diets containing Microcystis with considerable amounts of the cyanotoxin microcystin-LR (MC-LR) were fed to determine their impact on the physiological performance of the omnivorous Nile tilapia (Oreochromis niloticus) with regard to stress and growth performance. Four different diets were prepared based on a commercial diet (control, MC-5% [containing 5% dried Microcystis biomass], MC-20% [containing 20% dried Microcystis biomass], and Arthrospira-20% [containing 20% dried Arthrospira sp. biomass without toxin]) and fed to female Nile tilapia. Blood and tissue samples were taken after 1, 7, and 28 d, and MC-LR was quantified in gills, muscle, and liver by using high-performance liquid chromatography (HPLC). Only in the liver were moderate concentrations of MC-LR detected. The stress hormone cortisol and glucose were analyzed from plasma, suggesting that all modified diets caused only minor to moderate stress, which was confirmed by analyses of hepatic glycogen. In addition, the effects of the different diets on growth performance were investigated by determining gene expression of hypophyseal growth hormone (GH) and hepatic insulin-like growth factor-I (IGF-I). For all diets, quantitative reverse transcription-polymerase chain reaction (RT-qPCR) demonstrated no significant effect on gene expression of the major endocrine hormones of the growth axis, whereas classical growth data, including growth and feed conversion ratio, displayed slight inhibitory effects of all modified diets independent of their MC-LR content. However, no significant change was found in condition or hepatosomatic index among the various diets, so it seems feasible that dried cyanobacterial biomass might be even used as a component in fish diet for Nile tilapia, which requires further research in more detail.
Hidden harmonic quantum states in proteins: Did Davydov get the sign wrong? (2015)

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Zirkoniumdioxid mit definierter Partikelmorphologie und hierarchisch strukturiertem Porensystem durch kombinierte Exo‐ und Endotemplatsynthese (2010)

Abstract Zirkoniumdioxid ist nicht nur thermisch und meachnisch sehr stabil, sondern kann auch mit großer spezifischer Oberfläche und großem spezifischen Porenvolumen hergestellt werden. Dadurch ist es als Katalysatorträger interessant. Die Herstellung von Partikeln mit größeren Abmessungen gelingt über Exotemplatsynthese unter Verwendung von Aktivkohle mit kugelförmigen Partikeln. Der Zusatz eines Endotemplats erzeugt ein zusätzliches Mesoporensytem, so dass Zirkoniumdioxid mit hierarchisch strukturiertem Porensystem und zugleich definierter Partikelmorphologie zugänglich wird.
Response of a 0.25 μm thin-film silicon-on-sapphire CMOS technology to total ionizing dose (2010)

The radiation response of a 0.25 um silicon-on-sapphire CMOS technology is characterized at the transistor and circuit levels utilizing both standard and enclosed layout devices. Device-level characterization showed threshold voltage change of less than 170 mV and leakage current change of less than 1 nA for individual nMOSFET and pMOSFET devices at a total dose of 100 krad(SiO2). The increase in power supply current at the circuit level was less than 5%, consistent with the small change in off-state transistor leakage current. The technology exhibits good characteristics for use in the electronics of the ATLAS experiment at the Large Hadron Collider.
Synthesis of (.+-.)-7,8-epoxy-4-basmen-6-one by a transannular cyclization strategy (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of (.+-.)-7,8-epoxy-4-basmen-6-one by a transannular cyclization strategyAndrew G. Myers and Kevin R. CondroskiCite this: J. Am. Chem. Soc. 1993, 115, 17, 7926–7927Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/ja00070a068https://doi.org/10.1021/ja00070a068research-articleACS PublicationsRequest reuse permissionsArticle Views630Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
The treatment of macroprolactinomas with long acting repeatable bromocriptine. (1990)

peer reviewed
Investigation of Denitrification Kinetics Using Various Carbon Sources in Sequencing Batch Reactors at Cold Temperature (2008)

Facilities across North America are designing plants to meet stringent limit of technology (LOT) treatment for nitrogen removal. This is in response to the Chesapeake Bay Agreement, which will limit effluent total nitrogen to 3 mg/L. Of particular interest is the use of an alternate external carbon source to replace the most commonly used carbon, methanol. Replacing methanol with an alternate external carbon source for denitrification in the winter will be particularly important since methanol utilizer growth is stunted during colder temperatures. This study focuses on three external carbon sources: methanol, ethanol and acetate. The aim of this study was to obtain the specific denitrification rate (SDNR) of the substrates in two different contexts. Sequencing batch reactors (SBRs) were set up to acclimate carbon free biomass to the specified substrate while in-situ SDNRs were conducted concurrently. Once the biomass was acclimated to the corresponding substrate, a series of ex-situ SDNRs were performed using various biomass/substrate combinations. All experiments were conducted at 13°C. The results suggest that the SDNRs for acetate (32 mgNO3-N/gVSS/hr) and ethanol (30 mgNO3-N/gVSS/hr) are higher than that for methanol (9 mgNO3-N/gVSS/hr). Ethanol acclimated biomass fed with acetate resulted in the highest SDNR of 26 mgNO3-N/gVSS/hr.
Experimental verification of heat input during friction stir welding of Al alloy 5083 (2016)

Heat input during welding is a basic index for weld quality and service properties associated with the resulting microstructure. In this study, the heat inputs during friction stir welding of Al alloy 5083 at various welding parameters were measured by calorimetry. Multiple regression analysis of the data was conducted to determine an empirical equation to estimate the heat input with the input variables. The effect of the heat input on the grain size of the stir zone was also examined, and a good correlation between the grain size and heat input was obtained. This study obtained a systematic relationship between the input variables, heat input and grain size of the stir zone through experimental measurements.
α‐Helices propagating from stable nucleators exhibit unconventional thermal folding (2021)

Although the effect of thermal perturbations on protein structure has long been modeled in helical peptides, several details, such as the relation between the thermal stabilities of the propagating and nucleating segments of helices, remain elusive. We had earlier reported on the helix-nucleating propensities of covalent H-bond surrogate-constrained α-turns. Here, we analyze the thermal stabilities of helices that propagate along peptides appended to these α-helix nucleators using their NMR and far-UV CD spectra. Unconventional thermal folding of these helix models reveals that the helical fold in propagating backbones resists thermal perturbations as long as their nucleating template is intact. The threshold temperature of such resistance is also influenced by the extent of similarity between the natures of helical folds in the nucleating and propagating segments. Correlations between helicities and rigidities of helix-nucleating and helix-propagating segments reveal subtle interdependence, which explains cooperativity and residual helix formation during protein folding.
Surface-Confined Light Harvesting, Energy Transfer, and Amplification of Fluorescence Emission in Chromophore-Labeled Self-Assembled Monolayers (2000)

Mischungen von Cumarin-2- und Cumarin-343-Derivaten können sich auf einem Siliciumwafer zu Monoschichten selbstorganisieren, in denen Licht gesammelt und ein Energietransfer stattfinden kann (siehe schematische Darstellung). Photophysikalische Eigenschaften wie Fluoreszenzlöschung des Donors und Fluoreszenzverstärkung lassen sich durch Änderung des Molverhältnisses von Donor- zu Acceptorchromophor auf der Oberfläche einstellen oder – unter Verwendung eines dendritischen Linkers – durch Erhöhung der Zahl der Cumarin-2-Chromophore am Donoradsorbat.
Modeling human congenital disorder of glycosylation type IIa in the mouse: conservation of asparagine-linked glycan-dependent functions in mammalian physiology and insights into disease pathogenesis (2001)

The congenital disorders of glycosylation (CDGs) are recent additions to the repertoire of inherited human genetic diseases. Frequency of CDGs is unknown since most cases are believed to be misdiagnosed or unrecognized. With few patients identified and heterogeneity in disease signs noted, studies of animal models may provide increased understanding of pathogenic mechanisms. However, features of mammalian glycan biosynthesis and species-specific variations in glycan repertoires have cast doubt on whether animal models of human genetic defects in protein glycosylation will reproduce pathogenic events and disease signs. We have introduced a mutation into the mouse germline that recapitulates the glycan biosynthetic defect responsible for human CDG type IIa (CDG-IIa). Mice lacking the Mgat2 gene were deficient in GlcNAcT-II glycosyltransferase activity and complex N-glycans, resulting in severe gastrointestinal, hematologic, and osteogenic abnormalities. With use of a lectin-based diagnostic screen for CDG-IIa, we found that all Mgat2-null mice died in early postnatal development. However, crossing the Mgat2 mutation into a distinct genetic background resulted in a low frequency of survivors. Mice deficient in complex N-glycans exhibited most CDG-IIa disease signs; however, some signs were unique to the aged mouse or are prognostic in human CDG-IIa. Unexpectedly, analyses of N-glycan structures in Mgat2-null mice revealed a novel oligosaccharide branch on the "bisecting" N-acetylglucosamine. These genetic, biochemical, and physiologic studies indicate conserved functions for N-glycan branches produced in the Golgi apparatus among two mammalian species and suggest possible therapeutic approaches to GlcNAcT-II deficiency. Our findings indicate that human genetic disease due to aberrant protein glycosylation can be modeled in the mouse to gain insights into N-glycan-dependent physiology and the pathogenesis of CDG-IIa.
MGMT Epigenetics: The Influence of Gene Body Methylation and Other Insights Derived from Integrated Methylomic, Transcriptomic, and Chromatin Analyses in Various Cancer Types (2021)

Overall, our analysis illustrated the contrasting influence of promoter and gene body methylation on MGMT expression. These observations may help improve diagnostic assays for MGMT.
Development of a standardized laparoscopic caecum resection model to simulate laparoscopic appendectomy in rats (2014)

Laparoscopic appendectomy (LA) has become one of the most common surgical procedures to date. To improve and standardize this technique further, cost-effective and reliable animal models are needed. In a pilot study, 30 Wistar rats underwent laparoscopic caecum resection (as rats do not have an appendix vermiformis), to optimize the instrumental and surgical parameters. A subsequent test study was performed in another 30 rats to compare three different techniques for caecum resection and bowel closure. Bipolar coagulation led to an insufficiency of caecal stump closure in all operated rats (Group 1, n = 10). Endoloop ligation followed by bipolar coagulation and resection (Group 2, n = 10) or resection with a LigaSure™ device (Group 3, n = 10) resulted in sufficient caecal stump closure. We developed a LA model enabling us to compare three different caecum resection techniques in rats. In conclusion, only endoloop closure followed by bipolar coagulation proved to be a secure and cost-effective surgical approach.
Data Analytics and Machine Learning for Design-Process-Yield Optimization in Electronic Design Automation and IC semiconductor manufacturing (2017)

In response to the current challenges of end-of-Moore scaling, a systematic analysis of the data information flows in the Design-to-Manufacturing pipeline highlights opportunities for the introduction of (big) data analytics and machine learning solutions. In this paper we review the eco-system components and describe the fundamental data-flows in the IC Design-to-Manufacturing chain, highlighting both the well-established and functioning sub-systems, as well as the critical bottlenecks. A quantitative definition of physical design space coverage is proposed, as the unifying abstraction available for all components of the Design-to-Manufacturing flow, allowing for the construction of a computational framework where Data Analytics and Machine Learning methodologies and tools can be successfully applied. The juxtaposition of Design-Technology-Co-Optimization (DTCO) with the novel paradigm of DFM-as-Search and their necessary integration in the DFM computational toolkit, clearly exemplify how the all the advanced IC nodes (14, 10, 7 and 5nm) definitely require the adoption of a new class of correlation extraction algorithms for heterogeneous data sets.
Class Invariants for Quartic CM Fields (2007)

One can define class invariants for a quartic primitive CM field <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>K</mml:mi> </mml:math> as special values of certain Siegel (or Hilbert) modular functions at CM points corresponding to <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>K</mml:mi> </mml:math> . Such constructions were given by de Shalit-Goren and Lauter. We provide explicit bounds on the primes appearing in the denominators of these algebraic numbers. This allows us, in particular, to construct <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>S</mml:mi> </mml:math> -units in certain abelian extensions of a reflex field of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>K</mml:mi> </mml:math> , where <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>S</mml:mi> </mml:math> is effectively determined by <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>K</mml:mi> </mml:math> , and to bound the primes appearing in the denominators of the Igusa class polynomials arising in the construction of genus 2 curves with CM, as conjectured by Lauter.
Antibody levels against GLURP R2, MSP1 block 2 hybrid and AS202.11 and the risk of malaria in children living in hyperendemic (Burkina Faso) and hypo-endemic (Ghana) areas (2016)

These findings support further development of GLURP R2 and MSP1 block 2 hybrid, perhaps as a fusion vaccine antigen targeting malaria blood stage that can be deployed in areas of varying transmission intensity.
ChemInform Abstract: SYNTHESIS AND REACTIONS OF BICYCLO(3.1.0)HEXATRIENES (1978)

Abstract Die Verfasser nehmen an, daß durch zweifache sukzessive Dehydrohalogenierung von 4,6‐Dihalogen‐A′‐bicyclo‐ [3.2.0]hexenen 1,3‐Dehydro‐benzol ‐ das dem System (XII) entspricht ‐ erzeugt werden kann.
Differential Regulation of Sodium/Iodide Symporter Gene Expression by Nuclear Receptor Ligands in MCF-7 Breast Cancer Cells (2005)

The sodium/iodide symporter (NIS) mediates iodide uptake in lactating breast tissue and is expressed in some breast cancers. We have previously demonstrated that all-trans retinoic acid (tRA) stimulates NIS gene expression and the selective cytotoxic effect of beta-emitting radioiodide-131 ((131)I) in both in vitro and in vivo MCF-7 breast cancer cell systems. We studied the ability of natural and synthetic retinoids, in combination with other nuclear receptor ligands, to achieve greater and more sustained induction of NIS in MCF-7 cells and enhance (131)I-mediated cytotoxicity. Selective stimulation of retinoic acid receptor (RAR) beta/gamma produced marked NIS induction; and selective stimulation of RARalpha, RARgamma, or retinoid X receptor produced more modest induction. Maximal NIS induction was seen with 9-cis retinoic acid and AGN190168, a RAR beta/gamma-agonist. Dexamethasone (Dex), but not the other nuclear receptor ligands, in combination with tRA synergistically induced iodide uptake and NIS mRNA expression, predominantly by prolonging NIS mRNA half-life. The addition of Dex reduced the EC(50) of tRA for NIS stimulation to approximately 7%, such that 10(-7) m tRA with addition of Dex enhanced iodide uptake and selective cytotoxicity of (131)I greater than 10(-6) m tRA alone. AGN190168 combined with Dex synergistically increased iodide uptake and significantly prolonged induction (5 d) of iodide uptake compared with that induced by the combination of tRA/Dex or 9-cis retinoic acid/Dex. The addition of Dex reduced the effective dose of retinoid and prolonged the induction of NIS, especially with AGN190168, suggesting higher efficacy of (131)I after combination treatment.
Contrôle des modes supérieurs pour les antennes de Pérot-Fabry compactes - Impact sur la bande passante (2011)

National audience
An Entanglement-Based QKD System for Scalable Robust Multi-User Networks (2022)

We present entanglement-based quantum key distribution in a star-shaped network with time-bin coding. We demonstrate key exchange under typical operation conditions for metropolitan-scale networks. Without much efforts, it is scalable to more than 100 users.