gebhart/patrepeval huggingface dataset:
Cardiovascular events (CVE) in COPD patients (2013)

Aim: To estimate the prevalence of CVE and compare the characteristics of patients with or without CVE during acute exacerbation of COPD (AECOPD). Methods: We analyzed the data from 80 patients (men 67, age 64,2 ± 7,8 yrs, BMI 25,8 ± 8,8 kg/m2) with AECOPD (history, clinical presentation, X-ray, pulmonary test, blood gases, serum levels of Heart-type fatty acid-binding proteins (H-FABP) and BNP-fragment). Results: CVE (acute myocardial infarction, pulmonary edema, a new arrhythmia, acute decompensation of chronic heart failure) were reported in 28(35%) patients with AECOPD on 3,8 ± 2,1 admission day. There were no differences between patients with or without CVE in demographics characteristics. We observed significant differences in the biomarkers levels, pulmonary tests, hypoxemia, echocardiographic parameters (Table 1). Table 1. Characteristics of patients with AECOPD Parameters CVE(-) mean±SD CVE (+) mean±SD p Age,yrs 63,8±8,3 64,9±7,1 0,628 BMI, kg/m2 26,7±10,1 23,7±5,6 0,628 BNP-fragment, fmol/mL 927,4±1023,2 2339,1±1959,4 0,001 H-FABP, pg/mL 4728,8±3167,1 9908,7±7971,5 0,003 FEV1, % pred. 27,7±12,2 27,3±10,3 0,968 FVC, % pred. 64,2±16,5 64,7±19,3 0,888 TLC, L 8,5±1,3 9,5±1,7 0,021 FRC, L 6,7±1,9 7,8±2,3 0,020 RV, L 5,9±1,3 6,9±1,7 0,021 PaO2, mmHg 45,6±12,4 39,1±11,8 0,017 Left ventricular end-diastolic diameter, mm 46,7±9,9 52,6±9,3 0,015 Left ventricular ejection fraction, % 56,5±10,7 50,9±8,7 0,048 Systolic pulmonary artery pressure, mmHg 47,7±13,7 57,3±17,3 0,013 Hospital mortality, % 11,5 46,4 0,001 Conclusions: CVE may be more likely to occur in the setting of an AECOPD. Lung hyperinflation, hypoxemia, pulmonary hypertension, heart failure, mortality, increased levels of H-FABP, BNP-fragment were greater in AECOPD patients with CVE.
Leukocyte-Endothelial Cell Adhesive Interactions: Role of Xanthine Oxidase-Derived Oxidants (1991)

The objective of this study was to determine whether agents that either scavenge or inhibit the production of oxygen radicals can alter the adhesive interactions between leukocytes and venular endothelium elicited by ischemia-reperfusion. Cat mesenteric and intestinal blood flows were reduced to 20% of baseline for 1 hr, followed by 1 hr of reperfusion. Sixty minutes after reperfusion, red blood cell velocity (Vr), leukocyte rolling velocity (Vw), and the number of adherent leukocytes were measured in mesenteric venules. Then, either manganese-superoxide dismutase (Mn-SOD), catalase, desferrioxamine, or oxypurinol was administered intravascularly. Ten minutes later, repeat measurements were obtained and compared with pretreatment values. Catalase, Mn-SOD, and oxypurinol significantly attenuated neutrophil adherence while neither inactivated-catalase nor desferrioxamine altered the reperfusion-induced leukocyte adhesion. The ratio of Vw to erythrocyte velocity, an index of the fracture stress between rolling leukocytes and venular endothelium, was not altered by any of the agents studied. These results and data in the literature indicate that many of the agents that are commonly used to either scavenge or inhibit the production of oxygen radicals in postischemic tissues exert a significant inhibitory influence on leukocyte adhesion to microvascular endothelium in vivo. Our results are also consistent with the view that xanthine oxidase-derived oxidants contribute to the leukocyte-endothelial cell adhesive interactions associated with reperfusion of ischemic tissues.
Systemic Inflammatory Markers and Aspiration Cell Count May Not Differentiate Bacterial From Fungal Prosthetic Infections (2014)

Level IV, diagnostic study. See Instructions for Authors for a complete description of levels of evidence.
Crystallization of bisphenol a polycarbonate induced by supercritical carbon dioxide (1987)

Abstract Supercritical carbon dioxide readily induces crystallization in bisphenol A polycarbonate. Crystallization begins within one h of exposure to the CO 2 at temperatures and pressures as low as 75°C and 100 atm. The degree of crystallinity increases sharply as the CO 2 pressure is raised from 100 to 300 atm but levels off thereafter. This behavior is likely due to a minimum in the T g of the polycarbonate/CO 2 mixture owing to the opposite effects of the pressure on the T g of the polymer and on the equilibrium weight fraction of CO 2 absorbed. Percent crystallinities of over 20%, comparable to that achieved using acetone or other organic liquids, have been obtained after 2 h exposure to supercritical CO 2 . Since polycarbonate degasses quickly and quantitatively at ambient temperature and pressure, the high T g of bisphenol A polycarbonate can be regained in the crystallized material without further vacuum treatment.
Electrical stimulus artifact cancellation and neural spike detection on large multi-electrode arrays (2017)

Simultaneous electrical stimulation and recording using multi-electrode arrays can provide a valuable technique for studying circuit connectivity and engineering neural interfaces. However, interpreting these measurements is challenging because the spike sorting process (identifying and segregating action potentials arising from different neurons) is greatly complicated by electrical stimulation artifacts across the array, which can exhibit complex and nonlinear waveforms, and overlap temporarily with evoked spikes. Here we develop a scalable algorithm based on a structured Gaussian Process model to estimate the artifact and identify evoked spikes. The effectiveness of our methods is demonstrated in both real and simulated 512-electrode recordings in the peripheral primate retina with single-electrode and several types of multi-electrode stimulation. We establish small error rates in the identification of evoked spikes, with a computational complexity that is compatible with real-time data analysis. This technology may be helpful in the design of future high-resolution sensory prostheses based on tailored stimulation (e.g., retinal prostheses), and for closed-loop neural stimulation at a much larger scale than currently possible.
Routing in MPLS networks with probabilistic failures (2013)

We present a routing scheme for MPLS networks with probabilistic failures. Our routing scheme simultaneously maximizes the expected satisfied demand and minimizes the maximum link utilization of the network. Our approach is novel in that it is the first to jointly address the traffic engineering and the routing through reliable paths problems. In addition to the optimal routing algorithm, we present a lower complexity heuristic algorithm based on Linear Programming and Yen's algorithm. Finally, numerical results are presented to demonstrate the effectiveness of both our optimal and heuristic algorithms.
Faculty Opinions recommendation of Hyaluronan in limb morphogenesis. (2007)

Hyaluronan (HA) is a large glycosaminoglycan that is not only a structural component of extracellular matrices, but also interacts with cell surface receptors to promote cell proliferation, migration, and intracellular signaling. HA is a major component of the extracellular matrix of the distal subapical mesenchymal cells of the developing limb bud that are undergoing proliferation, directed migration, and patterning in response to the apical ectodermal ridge (AER), and has the functional potential to be involved in these processes. Here we show that the HA synthase Has2 is abundantly expressed by the distal subridge mesodermal cells of the chick limb bud and also by the AER itself. Has2 expression and HA production are downregulated in the proximal central core of the limb bud during the formation of the precartilage condensations of the skeletal elements, suggesting downregulation of HA may be necessary for the close juxtaposition of cells and the resulting cell-cell interactions that trigger cartilage differentiation during condensation. Overexpression of Has2 in the mesoderm of the chick limb bud in vivo results in the formation of shortened and severely malformed limbs that lack one or more skeletal elements. Skeletal elements that do form in limbs overexpressing Has2 are reduced in length, exhibit abnormal morphology, and are positioned inappropriately. We also demonstrate that sustained HA production in micromass cultures of limb mesenchymal cells inhibits formation of precartilage condensations and subsequent chondrogenesis, indicating that downregulation of HA is indeed necessary for formation of the precartilage condensations that trigger cartilage differentiation. Taken together these results suggest involvement of HA in various aspects of limb morphogenesis.
Cell Surfaces in Plant-Microorganism Interactions (1982)

Ethylene production and cell wall hydroxyproline-rich glycoprotein (HRGP) biosynthesis are greatly enhanced in melon (Cucumin melo cv. Cantaloup charentais) seedlings infected with Colletotrichum lagenarium. Short-term experiments performed in the presence of specific inhibitors of the ethylene pathway from methionine, namely l-canaline and amino-ethoxyvinylglycine, indicate that under non-toxic conditions, both ethylene and [(14)C]hydroxyproline deposition in the cell wall of infected tissues are significantly lowered. On the contrary, treatment of healthy tissues with 1-aminocyclopropane 1-carboxylic acid, a natural precursor of ethylene, stimulates both the production of the hormone and the incorporation of [(14)C]hydroxyproline into cell wall proteins.The data provide the first evidence of the in vivo effect of ethylene on the cell wall hydroxyproline-rich glycoprotein biosynthesis in plants.
(fluorescence quantum yield/fluorescence quenching/kinetics/protor (2016)

The photolysis-induced changes in the protein fluorescence intensity (at 320 nm) during the proton-pumping cycle of bacteriorhodopsin were examined by a delayed two-pulse technique in the time range 1 ,usec-20 msec at room temperature. No detectable change in the protein fluorescence intensity was ob- served on the earliest time scale within the lifetime of the inter- mediate K590, when retinal apparently undergoes the largest structural changes. The time dependence of the relative changes in fluorescence intensity did, however, display a close correlation with the population of the L550 and M412 intermediates. From a computer numerical fit of the data, with available published ki- netic parameters, the protein fluorescence quantum yields of the K590, L5so, and M412 intermediates are found to be 1.0, 0.92, and 0.80 of that for native bR570, respectively. The probable mecha- nisms of the observed fluorescence quenching during the photo- chemical cycle are qualitatively discussed.
Liver Fibrosis Scores and Prostate Cancer Risk and Mortality in the Atherosclerosis Risk in Communities Study (2023)

Investigating the link between liver fibrosis and prostate cancer risk and mortality, our study reveals the potential influence of liver health on prostate cancer development and on detection using PSA test, urging further research to understand the differential findings by race and to optimize prevention and intervention strategies.
The Alpha–Bet(a) of Salty Glucose Pyrolysis: Computational Investigations Reveal Carbohydrate Pyrolysis Catalytic Action by Sodium Ions (2014)

Biomass pyrolysis is a promising technology for the production of renewable fuels and chemicals from nonfood biomass. Given the potential of pyrolysis as a viable, cost-effective biomass deconstruction method, there is active interest in understanding the chemical transformations at the heart of the technology. It has long been known that the presence of alkali- and alkaline-earth-metal ions in biomass, such as Na+, significantly alters product yields of biomass pyrolysis, but the mechanism behind this effect has not been elucidated. In this work, we employ density functional theory (DFT) to reveal the stereoelectronic basis of the effect of sodium ions on several key glucose thermal decomposition reactions, such as the formation of levoglucosan and 5-hydroxymethylfurfural (5-HMF). β-d-Glucose is of interest for pyrolysis, as it is the monomer of cellulose and a key intermediate in cellulose pyrolysis. α-d-Glucose is included in this study, as the two anomers can readily interconvert under pyrolysis conditions. The computational results are consistent with the experimental results for α- and β-d-glucose pyrolysis with NaCl, which demonstrate that the products are the same as those produced in neat pyrolysis, but with differing relative yields. We find that the sodium ion changes the reaction rate coefficients to varying degrees, with approximately 70% of the reactions in this study catalyzed by Na+, approximately 25% inhibited by Na+, and the remainder showing virtually no effect on the rate coefficient. The variations in how the ion modifies the rate coefficient reflect how the particular stereochemistry of the transition state interacts with the ion. The sodium ions have a more subtle effect on reactant electronic structure. The results of this study provide a molecular-level understanding of how naturally occurring salts act as catalysts in biomass pyrolysis.
[P3–034]: TREATMENT WITH AN ALL D‐ENANTIOMERIC PEPTIDE IMPROVES COGNITIVE AND MOTORIC IMPAIRMENT IN TWO DIFFERENT ALZHEIMER MOUSE MODELS (2017)

The most common form of dementia worldwide is Alzheimer's disease (AD), a progressive neurodegenerative disease. Until now, no curative treatment is accessible. During the last years, our group designed all D-enantiomeric peptides, with the effort to capture toxic amyloid-beta (Ab) species. Here, we investigated the therapeutic in vivo efficacy of a newly developed D-enantiomeric peptide in old APP/PS1 animals at an age, when they have developed already a full blown amyloid pathology and in pyroglutamate-Ab expressing TBA2.1 mice, which are characterized by a motoric phenotype. Aged male APP/PS1 mice were orally treated with placebo or 200mg/kg peptide for 3 months. Homozygous TBA2.1 mice and non-transgenic littermates were treated with placebo, 20 mg/kg or 100 mg/kg peptide orally for 3 months. After treatment, mice were tested in different general, cognitive (APP/PS1) and motoric (TBA2.1) behavioural tests (Morris Water Maze, Open field test, SHIRPA test battery). Brains were analysed for changes in amyloid pathology, inflammation and neurodegeneration (histological and biochemical). Analysis of general behavioural tests resulted in no difference in behaviour of treated mice in comparison to non-transgenic littermates. After peptide treatment, APP/PS1 mice showed a significant improved cognitive performance in the Morris Water Maze compared to placebo controls (p = 0,05). Treated TBA2.1 mice revealed a significant lower SHIRPA-Score than non-treated littermates, indicating an improved motoric phenotype. APP/PS1 mice exhibited a significant decrease in plaque burden in the cortex. Treated non-transgenic littermates showed no abnormalities due to treatment with the peptide. We were able to show that the D-enantiomeric peptide has a truly curative effect on cognitive performance, motoric phenotype and plaque load in both mouse models without side effects on behaviour. These results qualify the peptide as promising candidate for the treatment of AD.
Highlights from The Eighth Annual Meeting of The National Academy of Inventors (2020)

This article presents highlights from the Eighth Annual Meeting of the National Academy of Inventors (NAI), which was held April 10 to 11, 2019, in Houston, Texas. The NAI meeting is held each year to honor academic invention and inventors, to inspire invention and invention networks, and to raise the profile of university and non-profit research. The 2019 meeting, "Connecting the Innovation Community", foregrounded the important relationships and nexuses among the institutions and organizations that support invention and entrepreneurship.
Body mass index predicts new-onset atrial fibrillation after cardiac surgery (2011)

Body mass index, age, undergoing valve surgery and male gender, are independent risk factors for POAF.
Hexaisopropoxyditungsten and dodecaisopropoxytetratungsten: W2(O-i-Pr)6 and W4(O-i-Pr)12. 1. Preparation, structure, and bonding. The first example of a metal-metal triple bond and its 12-electron cluster. Analogies with ethyne and cyclobutadiene (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHexaisopropoxyditungsten and dodecaisopropoxytetratungsten: W2(O-i-Pr)6 and W4(O-i-Pr)12. 1. Preparation, structure, and bonding. The first example of a metal-metal triple bond and its 12-electron cluster. Analogies with ethyne and cyclobutadieneMalcolm H. Chisholm, David L. Clark, Kirsten Folting, John C. Huffman, and Mark Hampden-SmithCite this: J. Am. Chem. Soc. 1987, 109, 25, 7750–7761Publication Date (Print):December 1, 1987Publication History Published online1 May 2002Published inissue 1 December 1987https://pubs.acs.org/doi/10.1021/ja00259a025https://doi.org/10.1021/ja00259a025research-articleACS PublicationsRequest reuse permissionsArticle Views168Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Dynamic Energy Optimization in Network-on-Chip-Based System-on-Chips (2010)

International audience
The Metabolite Profile in Culture Supernatant of Aster yomena Callus and Its Anti-Photoaging Effect in Skin Cells Exposed to UVB (2021)

<i>Aster yomena</i> (<i>A. yomena</i>) extract has anti-inflammatory, antioxidant, anti-asthma, and anti-atopic effects. However, the commercial use of <i>A. yomena</i> extract requires a long processing time with specific processing steps (including heat treatment and ethanol precipitation), and there are various environmental problems. We aimed to build a system to produce <i>A. yomena</i> extract by culturing the callus in a bioreactor that can allow rapid process scale-up to test the effect of extract (AYC-CS-E) isolated from culture supernatant of <i>A. yomena</i> callus on photoaging of human keratinocytes (HaCaT) caused by ultraviolet B (UVB) exposure. Through screening analysis based on ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS), 17 major metabolites were tentatively identified from AYC-CS-E for the first time. The suppression of cell proliferation caused by UVB was effectively alleviated in UVB-irradiated HaCaT cells treated with AYC-CS-E. Treatment with AYC-CS-E strongly induced the formation of type I procollagen and the inhibition of elastase in UVB-irradiated HaCaT cells and significantly reduced the expression of matrix metalloproteinase (MMP)-1. In addition, treatment of UVB-irradiated HaCaT cells with AYC-CS-E effectively improved various factors associated with an inflammatory reaction, skin damage recovery, skin moisture retention, and hyper-keratinization caused by photoaging, such as reactive oxygen species (ROS), pro-inflammatory cytokines, transforming growth factor beta (TGF-β), MMP-3, MMP-9, filaggrin, hyaluronic acid synthase 2 (HAS-2), keratin 1 (KRT-1), nuclear factor-kappa B (NF-κB), and nuclear factor erythroid 2-related factor 2 (Nrf2) at the gene and protein levels. These results suggest that AYC-CS-E can be used as a cosmetic ingredient for various skin diseases caused by photoaging, and the current callus culture system can be used commercially to supply cosmetic ingredients.
Effect of Pt / Al2 O 3 Catalyst on GaAs Grown by Low Pressure TEAs‐TMGa Organometallic Vapor‐Phase Epitaxy (1994)

Propagation properties of reactive hydrogen atoms generated by catalysts at low pressure were investigated by thermal etching experiments. It was found that the propagation distance of reactive hydrogen atoms is prolonged when the reactor pressure is decreased. The catalysts are used in low pressure organometallic vapor‐phase epitaxy growth of using triethylarsine. It is shown that carbon contamination in a substrate can be considerably reduced by the catalysts in a wider region compared with the case of atmospheric pressure growth.
Carney triad, SDH-deficient tumors, and Sdhb+/− mice share abnormal mitochondria (2015)

Carney triad (CTr) describes the association of paragangliomas (PGL), pulmonary chondromas, and gastrointestinal (GI) stromal tumors (GISTs) with a variety of other lesions, including pheochromocytomas and adrenocortical tumors. The gene(s) that cause CTr remain(s) unknown. PGL and GISTs may be caused by loss-of-function mutations in succinate dehydrogenase (SDH) (a condition known as Carney-Stratakis syndrome (CSS)). Mitochondrial structure and function are abnormal in tissues that carry SDH defects, but they have not been studied in CTr. For the present study, we examined mitochondrial structure in human tumors and GI tissue (GIT) of mice with SDH deficiency. Tissues from 16 CTr tumors (n=12), those with isolated GIST (n=1), and those with CSS caused by SDHC (n=1) and SDHD (n=2) mutations were studied by electron microscopy (EM). Samples of GIT from mice with a heterozygous deletion in Sdhb (Sdhb(+) (/-), n=4) were also studied by EM. CTr patients presented with mostly epithelioid GISTs that were characterized by plump cells containing a centrally located, round nucleus and prominent nucleoli; these changes were almost identical to those seen in the GISTs of patients with SDH. In tumor cells from patients, regardless of diagnosis or tumor type, cytoplasm contained an increased number of mitochondria with a 'hypoxic' phenotype: mitochondria were devoid of cristae, exhibited structural abnormalities, and were of variable size. Occasionally, mitochondria were small and round; rarely, they were thin and elongated with tubular cristae. Many mitochondria exhibited amorphous fluffy material with membranous whorls or cystic structures. A similar mitochondrial hypoxic phenotype was seen in Sdhb(+) (/-) mice. We concluded that tissues from SDH-deficient tumors, those from mouse GIT, and those from CTr tumors shared identical abnormalities in mitochondrial structure and other features. Thus, the still-elusive CTr defect(s) is(are) likely to affect mitochondrial function, just like germline SDH-deficiency does.