gebhart/patrepeval huggingface dataset:
Resolving 3D Human Pose Ambiguities With 3D Scene Constraints (2019)

To understand and analyze human behavior, we need to capture humans moving in, and interacting with, the world. Most existing methods perform 3D human pose estimation without explicitly considering the scene. We observe however that the world constrains the body and vice-versa. To motivate this, we show that current 3D human pose estimation methods produce results that are not consistent with the 3D scene. Our key contribution is to exploit static 3D scene structure to better estimate human pose from monocular images. The method enforces Proximal Relationships with Object eXclusion and is called PROX. To test this, we collect a new dataset composed of 12 different 3D scenes and RGB sequences of 20 subjects moving in and interacting with the scenes. We represent human pose using the 3D human body model SMPL-X and extend SMPLify-X to estimate body pose using scene constraints. We make use of the 3D scene information by formulating two main constraints. The inter-penetration constraint penalizes intersection between the body model and the surrounding 3D scene. The contact constraint encourages specific parts of the body to be in contact with scene surfaces if they are close enough in distance and orientation. For quantitative evaluation we capture a separate dataset with 180 RGB frames in which the ground-truth body pose is estimated using a motion capture system. We show quantitatively that introducing scene constraints significantly reduces 3D joint error and vertex error. Our code and data are available for research at https://prox.is.tue.mpg.de.
Epstein-Barr Virus Serology: Specificities of Sera Against EBNA 1 and EBNA 2 (1987)

Classical EBV serology includes titration of antibodies directed against viral capsid antigen (VCA), early antigen (EA), and EB nuclear antigen (EBNA) by indirect immunofluo-rescent assays. During primary EBV infection only,a kinetics of the antibody response occurs (1), while in each individual latently infected by EBV, i.e. in the general population, antibody titers remain stable for years (2). In a few cases, however,EBV serology may represent a marker for certain immunological changes in patients with diseases associated or not with EBV (3). Particularly, a weak, or an absence of,anti-EBNA response might reflect an alteration of cell mediated immunity. A more specific EBNA serology could recently be defined (4) since some of the different viral polypeptides of the EBNA complex have been identified. In fact, these EBNA antigens consist of up to five or six different component polypeptides. One, called EBNA 1, is defined as the product of the Bam H1-K fragment (5). EBNA 2, assigned to the Bam H1-WY and H region (6,7), seems to be required in the process of immortalization (8).
Monitoring physical device positions using RFID in electrical distribution switchboards (2006)

This paper presents the design of a system allowing us to monitor physical position of equipment's in electrical distribution switchboards. We obtained good performances by combining standard RFID (radio frequency identification) products and simple mechanical devices. By adopting a pragmatic approach and taking account of propagation in harsh environment, we finally realized a simple and quite low cost on/off RFID sensor for circuit breakers. Experimental results are confirmed and optimized using theoretical predictions. In addition, this principle could be used to monitor equipment's with multiple positions (2 and more) involved
Catalytic conversion of allyl alcohol to acetone over the zeolite H-ZSM-5 (1990)

G. J. Hutchings, D. F. Lee and C. D. Williams, J. Chem. Soc., Chem. Commun., 1990, 1475 DOI: 10.1039/C39900001475
<title>Photonic time-delay beam-forming architectures using polarization switching arrays</title> (1996)

Photonic time delay line (PTDL) architectures have been proposed for transmit/receive mode antenna applications. These architectures are based on two dimensional pixelated optical arrays that act as optical polarization switching elements. Such elements can be nematic liquid crystal (NLC) arrays, ferroelectric liquid crystal (FLC) arrays, and magneto-optic arrays. Optical delay lines can be formed using either free space or solid optics propagation, as well as non-polarization maintaining fiber propagation for the case of long time delays. In this paper, various optical array based optical beamformer architectures are presented and compared. These different architectures are based on Thompson polarization beamsplitters, and polarizing cube beamsplitters, for both transmissive and reflective geometries. A novel ternary time delay architecture is also introduced that can give 3<SUP>N</SUP> different time delay settings. In addition, a novel wavelength multiplexing architecture using a single channel dispersive fiber PTDL in cascade with multichannel PTDL is proposed for further hardware size and weight reduction.
Helminth Genomics: The Implications for Human Health (2009)

More than two billion people (one-third of humanity) are infected with parasitic roundworms or flatworms, collectively known as helminth parasites. These infections cause diseases that are responsible for enormous levels of morbidity and mortality, delays in the physical development of children, loss of productivity among the workforce, and maintenance of poverty. Genomes of the major helminth species that affect humans, and many others of agricultural and veterinary significance, are now the subject of intensive genome sequencing and annotation. Draft genome sequences of the filarial worm Brugia malayi and two of the human schistosomes, Schistosoma japonicum and S. mansoni, are now available, among others. These genome data will provide the basis for a comprehensive understanding of the molecular mechanisms involved in helminth nutrition and metabolism, host-dependent development and maturation, immune evasion, and evolution. They are likely also to predict new potential vaccine candidates and drug targets. In this review, we present an overview of these efforts and emphasize the potential impact and importance of these new findings.
Nonviral gene therapy by electrotransfer of hTNF-α soluble receptor variants: application to the treatment of collagen arthritis (2004)

Background La/SSB is a phosphoprotein that associates with various small RNA molecules. It has been found that the primary phosphorylation site of the molecule during various physiological processes is in Ser366. Objectives To determine whether the phosphorylation state of Ser366 could affect the antigenicity and the recognition of the protein by antibodies from patients with primary Sjgren's syndrome (pSS). Methods Peptides 349-368aa and phos349-368aa (with the Ser366 residue phosphorylated) were synthesized. Sera with anti-La specificity from 30 patients with pSS and sera from 19 normal individuals were examined against the two synthetic peptides in ELISA. The antibody specificity against the epitopes was tested with homologous and heterologous inhibition assays. Results Of pSS sera 23% reacted against the 349-368aa peptide. Sera binding to unphosphorylated peptide reacted also with phos349-368aa. Although the same sera gave a positive reaction against both peptides, the optical density values received from antibodies to phos349-368aa were higher, indicating a higher concentration or stronger affinity. When phos349-368aa was used as soluble inhibitor, in homologous inhibition the reactivity was almost completely abolished (92%). In contrast, when the unphosphorylated peptide was used as inhibitor, the reactivity of sera against phos349-368aa was only partially reduced (35%), indicating that sera from these patients possess two distinct groups of antibodies: one against the unphosphorylated and one against the phosphorylated epitope. Conclusion The phosphorylation of the serine366 residue resulted in a significant increase in antibody binding on epitope 349-368aa of La/SSB. These observations might explain the increased antigenicity of La/SSB autoantigen in various pathological situations in which phosphorylation may occur.
Collaborator of ARF (CARF) Regulates Proliferative Fate of Human Cells by Dose-dependent Regulation of DNA Damage Signaling (2014)

Collaborator of ARF (CARF) has been shown to directly bind to and regulate p53, a central protein that controls tumor suppression via cellular senescence and apoptosis. However, the cellular functions of CARF and the mechanisms governing its effect on senescence, apoptosis, or proliferation are still unknown. Our previous studies have shown that (i) CARF is up-regulated during replicative and stress-induced senescence, and its exogenous overexpression caused senescence-like growth arrest of cells, and (ii) suppression of CARF induces aneuploidy, DNA damage, and mitotic catastrophe, resulting in apoptosis via the ATR/CHK1 pathway. In the present study, we dissected the cellular role of CARF by investigating the molecular pathways triggered by its overexpression in vitro and in vivo. We found that the dosage of CARF is a critical factor in determining the proliferation potential of cancer cells. Most surprisingly, although a moderate level of CARF overexpression induced senescence, a very high level of CARF resulted in increased cell proliferation. We demonstrate that the level of CARF is crucial for DNA damage and checkpoint response of cells through ATM/CHK1/CHK2, p53, and ERK pathways that in turn determine the proliferative fate of cancer cells toward growth arrest or proproliferative and malignant phenotypes. To the best of our knowledge, this is the first report that demonstrates the capability of a fundamental protein, CARF, in controlling cell proliferation in two opposite directions and hence may play a key role in tumor biology and cancer therapeutics.
Deep Imaging with a New Method for Efficient 3D Broadband Marine Acquisition and Processing (2009)

We present a new method for broadband marine acquisition and processing capable of imaging deep targets while maintaining full high frequency bandwidth data. The method uses a deep interpolated streamer coverage approach (DISCover), which comprises a 3D shallow towed-streamer spread, designed to optimize the mid- and high-frequency parts of the bandwidth, together with data simultaneously acquired from a small number of deeper towed streamers. The depth of these deeper streamers is optimized for the low frequencies such that the combined overall bandwidth is enhanced. Because the deep streamers are only going to provide the low-frequency part of the bandwidth, we can more sparsely sample these data thus enabling efficient acquisition scenarios as fewer streamers are required. A 3D case study using this new acquisition method was acquired off the NW Shelf of Australia. The streamer spread consisted of six shallow streamers towed at a depth of 6m and two deeper streamers (below shallow streamers 2 and 5) towed at a depth of 20m. The resulting data exhibit both high resolution and deep penetration for subsalt and sub-basalt imaging, for example. Inversion for acoustic impedance, imaging, and velocity model building, also benefit from the broadband result.
An Approach to Nonparametric Inference on the Causal Dose Response Function (2023)

The causal dose response curve is commonly selected as the statistical parameter of interest in studies where the goal is to understand the effect of a continuous exposure on an outcome.Most of the available methodology for statistical inference on the dose-response function in the continuous exposure setting requires strong parametric assumptions on the probability distribution. Such parametric assumptions are typically untenable in practice and lead to invalid inference. It is often preferable to instead use nonparametric methods for inference, which only make mild assumptions about the data-generating mechanism. We propose a nonparametric test of the null hypothesis that the dose-response function is equal to a constant function. We argue that when the null hypothesis holds, the dose-response function has zero variance. Thus, one can test the null hypothesis by assessing whether there is sufficient evidence to claim that the variance is positive. We construct a novel estimator for the variance of the dose-response function, for which we can fully characterize the null limiting distribution and thus perform well-calibrated tests of the null hypothesis. We also present an approach for constructing simultaneous confidence bands for the dose-response function by inverting our proposed hypothesis test. We assess the validity of our proposal in a simulation study. In a data example, we study, in a population of patients who have initiated treatment for HIV, how the distance required to travel to an HIV clinic affects retention in care.
Metrologies for characterization of flatness and thickness uniformity in temporarily bonded wafer stacks (2012)

In the past few decades, the semiconductor industry has grown very quickly and the technology has advanced as predicted by Moore's law. In order to improve the cost effectiveness of semiconductor processes, the device size has been reduced, but the wafer diameter continues to increase. Furthermore, in order to overcome the barrier of Moore's law, Three-Dimensional Stacked Integrated Circuits (3DS-IC) integration technology attracts more and more interests in the semiconductor industry. One of the key processes of 3DS-IC technology is the implementation of temporary bonding solution which gives the ability to handle and process thinned Si wafers. Flatness and thickness uniformity of a thin Si wafer is critical for product reliability and yield. As a result, not only total thickness variation (TTV) of the thin Si wafer but also TTV/flatness of the wafer stack matters.
The random inactivation of the X chromosome carrying the defective gene responsible for X-linked hyper IgM syndrome (X-HIM) in female carriers of HIGM1. (1994)

The molecular origin of X-linked hyper IgM syndrome has recently been identified as a defect in the ligand of CD40, gp39, a protein expressed on the surface of activated T cells. The availability of detailed pedigrees for three families with affected males allowed assessment of the random or nonrandom nature of the inactivation of the defective X chromosome as well as a determination of the origin of the mutation. X chromosome inactivation was studied because of the relevance to the ability to detect carriers of HIGM1 and the potential for phenotypic effect in the carriers. Using immunostaining, PCR, and DNA sequencing, we found that the defective gene for gp39 is not selectively inactivated. Even in the presence of extremely skewed inactivation, normal levels of serum Ig were found. In carriers in which the defective gene is predominantly expressed, staining alone revealed the carrier status reliably while cloning and sequencing of the cDNA was necessary when the normal gene was predominantly expressed. Unlike some other X-linked defects where extreme Lyonization may lead to disease, a small population of cells expressing the wild-type gp39 is sufficient to maintain normal humoral immunity and prevent the clinical symptoms of X-HIM.
Phytochemical Composition and Cytoprotective Properties of the Endemic Sideritis sipylea Boiss Greek Species: A Valorization Study (2022)

<i>Sideritis sipylea</i> Boiss. (Fam. Lamiaceae) is an endemic plant of the North Aegean Islands (Greece), commonly known as ironwort. Traditionally, its aerial parts have been used to relieve several ailments, especially gastrointestinal disorders, however, with scant knowledge about the pharmacological basis. In the present study, an endemic <i>S. sipylea</i> Greek species from Lesvos Island has been characterized for phytochemical composition and biological activities, in order to give a possible scientific basis to its traditional use and to highlight a further nutraceutical interest as a source of bioactive phytochemicals and extracts. Three different fractions obtained from a methanolic extract of <i>S. sipylea</i> aerial parts by using ethyl acetate with 10 (S10), 20 (S20), and 50% (S50) methanol as fractionation solvents were phytochemically characterized. Moreover, their antioxidant power and cytoprotective activity in different human cell lines were evaluated. The phytochemical analysis highlighted the presence of flavonoids, iridoids, and phenolic acids in all the tested samples. Particularly, the S10 fraction mainly contained iridoids, while S20 and S50 lavandulifolioside and chlorogenic acid, respectively. The fractions also showed antioxidant properties, S10 and S20 being the most potent. When assessed in human cholangiocytes, they counteracted the cytotoxicity of the tBOOH pro-oxidant agent, by reducing ROS levels and affecting GSH antioxidant system. The present findings highlight a possible interest in S10 and S20 fractions from <i>S. sipylea</i> as sources of bioactive molecules and stimulate further studies in order to characterize their possible application for nutraceutical and pharmaceutical purposes.
Detection of Ebola Virus RNA through Aerosol Sampling of Animal Biosafety Level 4 Rooms Housing Challenged Nonhuman Primates (2016)

Ebola virus disease is a serious illness of humans and nonhuman primates (NHPs). Direct contact has been shown to be the primary source of Ebola (EBOV) transmission. We used a high-volume air sampler to determine whether EBOV could be detected during 3 independent studies with EBOV-challenged NHPs. Viral RNA was recovered during days 9 and 10 of Study I and days 7 and 8 of Study III. Viral RNA levels were below limits of detection during all other collections. The results demonstrate that the biosafety level 4 (BSL-4) suit protects workers from aerosols in a BSL-4 environment using proper engineering and administrative controls.
Time-dependent aspects of the flow in the carotid bifurcation: continuous DPIV and computational results (2003)

Cerebrovascular disease (stroke) and cerebral ischemia are a leading cause of mortality and morbidity. Approximately 80% of all strokes are caused by ischemia. Occlusion or stenosis in the internal carotid artery (ICA), which starts at the bifurcation of the common carotid artery (CCA), is the result of disease of the arterial wall. Complication by thrombosis or embolism is the most frequent cause of cerebral ischemia and infarction. Biofluid factors such as abnormal shear stresses and turbulence have been cited to promote these disorders. Continuous digital particle image velocimetry (CDPIV) is used to map the flow field of vascular model of the ICA and obtain its time and spectral signatures. Computational fluid dynamics (CFD) is used to calculate and validate the hemodynamic factors governing the flow field. Continuous sequences of resulting images are given as animated presentation of distensible carotid bifurcation model. High shear stress peaks and vortices are observed at the bifurcation heel. Flow reversal or separation is Reynolds number dependent. The flow profile and spectra were dependent on geometry and elasticity. The combination of CDPIV and CFD seems to be a powerful tool enabling complementary time dependent assessments of the demanding field of cerebrovascular disease.
Table S4 from Integrative Kinome Profiling Identifies mTORC1/2 Inhibition as Treatment Strategy in Ovarian Clear Cell Carcinoma (2023)

&lt;p&gt;Supplementary Table 4 | Clinicopathological characteristics (n=70 patients).&lt;/p&gt;
On Relaxed Squashed Embedding of Graphs into a Hypercube (1989)

Task allocation in an n-dimensional hypercube (or an n-cube) multicomputer consists of two sequential steps: (i) determination of the size of the cube required to accommodate an incoming task composed of a set of interacting modules, and (ii) allocation of the task to a cube of the dimension determined from (i). Step (i) is usually done manually by the users, which is often difficult and leads to the underutilization of processors in an n-cube system. The main objective here is to automate step (i). Step (ii) has already been addressed in [ IEEE Trans. Comput., 36 (1987), pp. 1396–1407]. Each incoming task is represented by a graph in which each node denotes a module of the task and each link represents the need of intermodule communication. Each module must be assigned to a subcube in such a way that node adjacencies in the associated task graph are preserved. This assignment problem is called the relaxed squashed (RS) embedding of a graph, and the minimal dimension of a cube required for a given graph is termed the weak cubical dimension of the graph. Some mathematical properties of the RS embedding are derived first. In light of these mathematical properties, fast algorithms are developed to RS embed task graphs. A heuristic function for the $A^ * $ search algorithm is also derived to determine the weak cubical dimension of a graph.
New Features of Systemic Vasculitides (2014)

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Gastrointestinal Transit of Amoxicillin Modified-Release Tablets and a Placebo Tablet Including Pharmacokinetic Assessments of Amoxicillin (1996)

The modified-release tablet of amoxicillin administered postprandially apparently increases the amoxicillin release time in the stomach. The relevance of its use for anti-H. pylori treatment can be questioned.
Study of flow-induced fiber in-plane deformation during high pressure resin transfer molding (2021)

High Pressure Resin Transfer Molding (HP-RTM) is a new variant of composite Resin Transfer Molding (RTM) process that enables a short cycle time and a high composite strength to weight ratio, thus presents a great potential for fabricating automotive structural parts. Due to the high injection pressure, fiber-tow washout is becoming one of the major defects which impact the properties of composite materials. To predict and mitigate the fiber-tow washout problem, approaches of both experimental process optimization and computational prediction are essential. In this paper, an experimental study of fiber-tow washout is undertaken to determine the flow injection limits beyond which the preform deformation can be observed at various fiber volume fractions. A feasibility map is developed for a specific fabric and resin combination. It provides a means to determine the injection rates and fiber volume fractions to fabricate a quality part with minimal in-plane fiber washout due to the hydrodynamically flow-induced force during the HP-RTM process.
ChemInform Abstract: Room‐Temperature MOCVD of Sb2Te3 Films and Solution Precipitation of M2Te3 (M: Sb, Bi) Powders via a Novel (N,N‐Dimethylamino) trimethylsilane Elimination Reaction. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.