gebhart/patrepeval huggingface dataset:
Revisiting the anticancer properties of phosphane(9-ribosylpurine-6-thiolato)gold(I) complexes and their 9H-purine precursors (2022)

New mono- and di-nuclear thio-purine and thio-purine nucleoside gold(I) complexes were synthesized, characterized, and evaluated in vitro for biological activities in comparison to related known purine complexes. By combining known anti-tumoral thio-purines with R<sub>3</sub>PAu moieties as present in auranofin, complexes with enhanced effects and selectivities were obtained, which not only act as cytostatics, but also disrupt tumor-specific processes. Their IC<sub>50</sub> values in cytotoxicity test with tumor cell lines ranged from three-digit nanomolar to single-digit micromolar, revealing a tentative structure-activity relationship (SAR). Both the residues R<sup>2</sup> of the phosphane ligand and R<sup>1</sup> at C2 of the pyrimidine ring had a significant impact on the cytotoxicity. In most cases, the introduction of a ribo-furanosyl group at N9 of the purine led to a distinctly more cytotoxic complex. Most complexes were more active against multi-drug-resistant tumor cells or such lacking functional p53 when compared to the respective untreated wild type cell lines. Some nucleoside complexes displayed an interesting dose-dependent dual mode of action regarding cell cycle arrest and DNA repair mechanism. Some phosphane(purine-6-thiolato)gold (I) complexes had a stronger inhibitory effect on the thioredoxin reductase (TrxR) and on the reactive oxygen species (ROS) generation in cancer cells than is typical of other gold complexes. They also led to DNA fragmentation and showed anti-angiogenic effects. Their stability under test conditions was demonstrated by <sup>77</sup>Se NMR monitoring of an exemplary selenopurine complex.
Very high-efficiency semiconductor wafer-bonded transparent-substrate (AlxGa1−x)0.5In0.5P/GaP light-emitting diodes (1994)

Data are presented demonstrating the operation of transparent-substrate (TS) (AlxGa1−x)0.5In0.5P/GaP light-emitting diodes (LEDs) whose efficiency exceeds that afforded by all other current LED technologies in the green to red (560–630 nm) spectral regime. A maximum luminous efficiency of 41.5 lm/W (93.2 lm/A) is realized at λ∼604 nm (20 mA, direct current). The TS (AlxGa1−x)0.5In0.5P/GaP LEDs are fabricated by selectively removing the absorbing n-type GaAs substrate of a p-n (AlxGa1−x)0.5In0.5P double heterostructure LED and wafer bonding a ‘‘transparent’’ n-GaP substrate in its place. The resulting TS (AlxGa1−x)0.5In0.5P/GaP LED lamps exhibit a twofold improvement in light output compared to absorbing-substrate (AS) (AlxGa1−x)0.5In0.5P/GaAs lamps.
New DPD Tracking Servo Method by Signal Processing for High-Density ROM Discs (2007)

Differential phase detection (DPD) is the most popular tracking error detection method for read-only optical discs (ROM discs). However, in this method, tracking error signals deteriorate for high-density discs such as over 30-GB Blu-ray discs (BDs) where zero-cross detections severely loose their accuracy. To provide a solution for this technical issue, we proposed a new zero-cross detection free DPD (ZF-DPD) method by applying the least-mean-square (LMS) algorism adaptive equalizer, and experimentally confirmed the effectiveness for a 33-GB BD ROM disc.
All-Electronic Flexibly Programmable 864-Gb/s Single-Carrier PDM-64-QAM (2014)

We generate a 72-GBd single-carrier 64-QAM signal using high-speed digital-to-analog converters. We obtain a record line rate of 864 Gb/s on a single wavelength and demonstrate 5-channel WDM transmission over 400 km of fiber.
Relating interesting quantitative time series patterns with text events and text features (2013)

In many application areas, the key to successful data analysis is the integrated analysis of heterogeneous data. One example is the financial domain, where time-dependent and highly frequent quantitative data (e.g., trading volume and price information) and textual data (e.g., economic and political news reports) need to be considered jointly. Data analysis tools need to support an integrated analysis, which allows studying the relationships between textual news documents and quantitative properties of the stock market price series. In this paper, we describe a workflow and tool that allows a flexible formation of hypotheses about text features and their combinations, which reflect quantitative phenomena observed in stock data. To support such an analysis, we combine the analysis steps of frequent quantitative and text-oriented data using an existing a-priori method. First, based on heuristics we extract interesting intervals and patterns in large time series data. The visual analysis supports the analyst in exploring parameter combinations and their results. The identified time series patterns are then input for the second analysis step, in which all identified intervals of interest are analyzed for frequent patterns co-occurring with financial news. An a-priori method supports the discovery of such sequential temporal patterns. Then, various text features like the degree of sentence nesting, noun phrase complexity, the vocabulary richness, etc. are extracted from the news to obtain meta patterns. Meta patterns are defined by a specific combination of text features which significantly differ from the text features of the remaining news data. Our approach combines a portfolio of visualization and analysis techniques, including time-, cluster- and sequence visualization and analysis functionality. We provide two case studies, showing the effectiveness of our combined quantitative and textual analysis work flow. The workflow can also be generalized to other application domains such as data analysis of smart grids, cyber physical systems or the security of critical infrastructure, where the data consists of a combination of quantitative and textual time series data.
Investigation of Partial Pressure Distribution of Undecomposed NH3 in Carbonitiriding Atmosphere (2008)

We have beeen investigating the nitrogen penetration mechanism of high carbon chromium bearing steel JIS-SUJ2 (SAE52100 equivalent) in the carbonitriding process. Our previous research results exhibited that partial H2 pressures and residual NH3, and carbon activity in an ambient furnace atmosphere were the rate-detemining factors of nitrogen penetration. In this study, an atmospheric imbalance of partial NH3 pressure was experimentally analyzed. In addition, distribution map of the partial NH3 pressure was calculated by CFD analysis in which the decomposition reaction rate was take into account. The extrapolated data obtained from CFD analysis corresponds well with the experimental data. Hence, we believe that the CFD analysis is effective in order to control carbonitriding quality and to devise heat treatment furnace structures.
Concentration Quenching Behavior of Thermally Activated Delayed Fluorescence in a Solid Film (2017)

Concentration-dependent photophysical properties were investigated using an approach for more rigorous interpretation through well-defined concentration quenching equations derived from an optical exciton model. These calculations verified that the solid-state self-quenching process of the 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzne (4CzIPN) emitter in a host matrix is controlled by the Dexter energy transfer model. By extension, we found that the reduction in the radiative singlet decay rate (krS) can be ascribed to the stabilization of excited states. This process may increase the efficiency of intersystem crossing as the doping concentration of 4CzIPN increases in the host material in a solid matrix. Furthermore, the nonradiative triplet decay process (knrT) could be an important consideration for estimating the exact concentration quenching rate constant value and the efficiency of reverse intersystem crossing corresponding to experimental photoluminescence behaviors with the various doping concentrations.
Review of: "Dynamic X-ray elastography using a pulsed photocathode source" (2021)

Potential competing interests: The author(s) declared that no potential competing interests exist.
Role of adenosine kinase in cochlear development and response to noise (2010)

Adenosine signalling has an important role in cochlear protection from oxidative stress. In most tissues, intracellular adenosine kinase (ADK) is the primary route of adenosine metabolism and the key regulator of intracellular and extracellular adenosine levels. The present study provides the first evidence for ADK distribution in the adult and developing rat cochlea. In the adult cochlea, ADK was localized to the nuclear or perinuclear region of spiral ganglion neurons, lateral wall tissues, and epithelial cells lining scala media. In the developing cochlea, ADK was strongly expressed in multiple cell types at birth and reached its peak level of expression at postnatal day 21 (P21). Ontogenetic changes in ADK expression were evident in the spiral ganglion, organ of Corti, and stria vascularis. In the spiral ganglion, ADK showed a shift from predominantly satellite cell immunolabelling at P1 to neuronal expression from P14 onward. In contrast to the role of ADK in various aspects of cochlear development, the ADK contribution to the cochlear response to noise stress was less obvious. Transcript and protein levels of ADK were unaltered in the cochlea exposed to broadband noise (90-110 dBSPL, 24 hr), and the selective inhibition of ADK in the cochlea with ABT-702 failed to restore hearing thresholds after exposure to traumatic noise. This study indicates that ADK is involved in purine salvage pathways for nucleotide synthesis in the adult cochlea, but its role in the regulation of adenosine signalling under physiological and pathological conditions has yet to be established.
Diabetic kidney disease: Act now or pay later (2010)

aFor the 2010 International Society of Nephrology/International Federation of Kidney Foundations World Kidney Day Steering Committee bInternational Diabetes Federation
Inside Cover: An Expanded Set of Fluorogenic Sulfatase Activity Probes (ChemBioChem 8/2014) (2014)

The inside cover picture shows the distinctive sulfatase activity patterns produced by each of three fluorogenic probes: 3-O-methylfluorescein sulfate (green), resorufin-sulfate (yellow) and DDAO-sulfate (red). Mycobacterial lysates, which contain a variety of sulfatases, were resolved on native protein gels before exposure to fluorogenic probe and fluorescence imaging. For details, see the paper by K. E. Beatty et al. on p. 1101 ff.
PHD2 inactivation in Type I cells drives HIF‐2α‐dependent multilineage hyperplasia and the formation of paraganglioma‐like carotid bodies (2018)

The carotid body is a peripheral chemoreceptor that plays a central role in mammalian oxygen homeostasis. In response to sustained hypoxia, it manifests a rapid cellular proliferation and an associated increase in responsiveness to hypoxia. Understanding the cellular and molecular mechanisms underlying these processes is of interest both to specialized chemoreceptive functions of that organ and, potentially, to the general physiology and pathophysiology of cellular hypoxia. We have combined cell lineage tracing technology and conditionally inactivated alleles in recombinant mice to examine the role of components of the HIF hydroxylase pathway in specific cell types within the carotid body. We show that exposure to sustained hypoxia (10% oxygen) drives rapid expansion of the Type I, tyrosine hydroxylase expressing cell lineage, with little transdifferentiation to (or from) that lineage. Inactivation of a specific HIF isoform, HIF‐2α, in the Type I cells was associated with a greatly reduced proliferation of Type I cells and hypoxic ventilatory responses, with ultrastructural evidence of an abnormality in the action of hypoxia on dense core secretory vesicles. We also show that inactivation of the principal HIF prolyl hydroxylase PHD2 within the Type I cell lineage is sufficient to cause multilineage expansion of the carotid body, with characteristics resembling paragangliomas. These morphological changes were dependent on the integrity of HIF‐2α. These findings implicate specific components of the HIF hydroxylase pathway (PHD2 and HIF‐2α) within Type I cells of the carotid body with respect to the oxygen sensing and adaptive functions of that organ
STUDY ON MECHANISMS OF SEDIMENT DEPOSITION ON SURFACE OF VEGETATED MICROTOPOGRAPHY AFTER A FLOOD EVENT (2019)

本研究では砂州の切り下げ事業後に進出した草本域に関して，現地観測の結果から得た粒度分布や，高頻度の撮影画像から得たSfM-MVS解析による微地形の変遷から，その維持機構を検討した．特に草本群落が河床材料の被覆を受けずに維持されている領域において，平均年最大値規模の出水後に細粒分のみならず砂分を多く含む土砂が堆積する現象に関して，数値解析を併用することで水理的な条件を検討した．解析では，簡易な植生内流速の算出法を用いることで，粒子沈降速度との比較から浮遊砂としての連行条件を推定可能であると仮定した．結果からは，現地観測結果との比較において，浮遊砂としての連行条件を満たしていない領域において，砂分の堆積が多く見られた．
Evaluation of a probe hybridisation serotyping method for group A rotavirus. (1993)

Serotype-specificity and sensitivity of oligonucleotide probes to serotype human rotaviruses was assessed. Probes could detect as little as 6.3 ng of homologous RNA and none reacted with as much as 100 ng of heterologous RNA. Northern-blot analysis revealed that probes reacted with one of genomic segments 7, 8 or 9 of corresponding serotypes.
Stereo Visual Servoing for High Accuracy Tracking Control in 3-D Space (2002)

ビジュアルサーボを用いて外部環境に対して働きかけるためには, 正確な位置決め制御が必要である。しかし, 市販のCCDカメラは高解像度を有する反面, サンプリングの問題から応答性を上げる事が困難であった。そこで, 本研究では視覚センサと位置センサを併用し, 応答性を犠牲にせずに対象物体の正確な位置情報を得るビジュアルサーボシステムを提案する。人体上腕を模した多関節マニピュレータに2台のCCDカメラを設置し, 3次元空間を移動する対象物体に対してマニピュレータ手先の追従制御を行い提案手法の有用性を検証する。
BERTPerf: Inference Latency Predictor for BERT on ARM big.LITTLE Multi-Core Processors (2022)

Hardware-aware Neural Architecture Search (NAS) and mapping & scheduling optimization methods are being used to find efficient implementations of computationally-intense language models such as BERT. This requires measuring real hardware inference latency: good design decisions simply cannot be made with proxy metrics such as FLOPs or the number of parameters. However, the time required to perform on-device latency measurements is prohibitive (e.g., a few days to a few weeks over the course of an optimization run). To address this, we present BERTPerf, a low-cost, highly-accurate method to predict the inference time of BERT on ARM big.LITTLE multi-core processors. BERTPerf exploits latency patterns at the layer-level to reduce on-device latency measurements, and captures the effect of caching and intermediate tensor allocations to reduce latency prediction error. BERTPerf reduces the maximum prediction error by 7–11% compared to the state-of-the-art, and requires 75% less on-device measurements compared to existing work at the same prediction error.
Full-state software GNSS and reduced MEMS IMU measurement processing for urban navigation (2009)

This paper presents an integration of partial-IMU measurements into the codebase of an existing software GNSS receiver for land vehicle navigation. Full-state filtering was implemented in contrast ...
Multiple sclerosis and psychiatric disorders: Comorbidity and sibling risk in a nationwide Swedish cohort (2014)

We found a strong positive association between MS and bipolar disorder and depression that could not be explained by genetic liability. The unexpected negative association between MS and schizophrenia might be spurious or indicate possible protective mechanisms that warrant further exploration.
Characterization of Changes in Electrophysiological Activity in an Operational Environment (2005)

The purpose of this study is to characterize differences in EEG collected under stationary conditions and that collected in mobile settings. EEG activity has not been evaluated in operational settings due to difficulties associated with processing of EEG in real-world settings such as real-time removal of artifacts, operational environments, and possible differences in EEG frequency associated with mobility. Utilization of EEG measures of cognitive activity in dynamic environments demands the use of real-time algorithms of signal decontamination and characterization of specific components of EEG activity. In this study, EEG was collected and filtered in real-time in a set of controlled stationary scenarios and similar mobile scenarios in order to characterize differences in EEG power, electrode locations, and individual differences under mobility while participants performed tasks of variable difficulty. Results illustrate that the lack of systematic differences in EEG spectral power associated with mobility may point to feasibility of successful collection and analysis of EEG activity in such settings.
Thin Films: Sub‐Micrometer Structure Formation during Spin Coating Revealed by Time‐Resolved In Situ Laser and X‐Ray Scattering (Adv. Funct. Mater. 46/2017) (2017)

The droplet-like morphology, typical for many polymer-small-organic-molecule blends processed by spin coating, is quantitatively analyzed by gracing incidence small angle X-ray scattering by Giuseppe Portale and co-workers in article number 1702516. Using a combination of simultaneous X-ray scattering, laser scattering, and laser interferometry measurements, a formation mechanism based on liquid-liquid demixing followed by solvent partitioning is observed during spin coating.
Inhibitor of Differentiation-1 as a Novel Prognostic Factor in NSCLC Patients with Adenocarcinoma Histology and Its Potential Contribution to Therapy Resistance (2011)

In our series, Id1 levels showed an independent prognostic value in patients with adenocarcinoma, regardless of the stage. Id1 silencing may sensitize adenocarcinoma cells to radiotherapy and chemotherapy.
Induction of Diverse Cryptic Fungal Metabolites by Steroids and Channel Blockers (2022)

Abstract Fungi offer a deep source of natural products but remain underutilized. Most biosynthetic gene clusters (BGCs) that can be detected are silent or “cryptic” in standard lab cultures and their products are thus not interrogated in routine screens. As genetic alterations are difficult and some strains can only be grown on agar, we have herein applied an agar‐based high‐throughput chemical genetic screen to identify inducers of fungal BGCs. Using R. solani and S. sclerotiorum as test cases, we report 13 cryptic metabolites in four compound groups, including sclerocyclane, a natural product with a novel scaffold. Steroids were the best elicitors and follow‐up studies showed that plant‐steroids trigger sclerocyclane synthesis, which shows antibiotic activity against B. plantarii , an ecological competitor of S. sclerotiorum . Our results open new paths to exploring the chemical ecology of fungal‐plant interactions and provide a genetics‐free approach for uncovering cryptic fungal metabolites.
Amino Acids and Peptides. XXV. Preparation of Fibronectin-Related Peptide Poly(ethylene glycol) Hybrids and Their Inhibitory Effect on Experimental Metastasis. (1995)

Hybrids of fibronectin-related peptides [Arg-Gly-Asp (RGD), Arg-Gly-Asp-Ser (RGDS)] and poly(ethylene glycol) (PEG) were prepared and their inhibitory effects on experimental metastasis in mice were examined. The inhibitory effect of RGD was markedly potentiated by hybrid formation with poly(ethylene glycol) #6000. As to inhibitory effect, RGD was more potent than RGDS and RGD PEG hybrids were superior to RGDS PEG hybrids. Hybrid formation with PEG #6000 was more effective than that with PEG #4000.
Optical Disk Recording Using a GaN Blue-Violet Laser Diode (2000)

The combination of a GaN laser diode and a 0.85 numerical aperture objective has achieved an optical storage capacity of over 22 GB. Owing to sufficient modulation ability and low-noise characteristics, GaN semiconductor lasers possess adequate quality to be light sources in optical recording systems. A bit size of 130 nm×300 nm, corresponding to the areal recording density of 16.5 Gbit/in. 2 , was realized on a six-layered thin-cover phase-change disk with a crystallization-promoting structure. Each active layer was inversely stacked and was thermally as well as optically optimized for the blue-violet light sources. A new small electromagnetic actuator with a lightweight φ3 mm two-element lens has extended its servo-bandwidth up to 8 kHz and enabled precise focusing control at the data transfer rate of 35 Mbps.
One-dimensional model of the programming kinetics of conductive-bridge memory cells (2011)

A one-dimensional model of filament growth in conductive-bridge memory cells is presented, in which ions are thermally excited from the anode surface into the electrolyte, pulled by the electric field through a periodic series of wells and reduced at the cathode to form a metallic filament. The voltage, temperature, and thickness dependencies of the time required to program a cell are calculated, and material parameters for Ag/GeS2/W cells are obtained by comparison to experiment. The relation of the model to recent observations of quantized conductance is highlighted, as is the need for further study of the Ag/GeS2 interface.
AN ENZYME INHIBITOR, PANOSIALIN, PRODUCED BY STREPTOMYCES (1971)

In the screening of streptomyces culture filtrates for inhibitors of viral sialidase, acid phosphatase and polygalacturonase, a new type of compound was isolated and named panosialin. It had the following ID50 values : 9×10-6 M, 3.8×10-5M and 3.9×10-5M againt sialidase, acid phosphatase and polygalacturonase respectively. In this paper, characters of the panosialin-producing strains and the isolation of panosialin are described. It was found to bind to protein and to have an action similar to that of detergents.
Speech Recognition Using Connectionist Networks Dissertation Proposal (1988)

The thesis of the proposed research is that connectionist networks are adequate models for the problem of acoustic phonetic speech recognition by computer. Adequacy is defined as suitably high recognition performance on a representative set of speech recognition problems. Seven acoustic phonetic problems are selected and discussed in relation to a physiological theory of phonetics. It is argued that the selected tasks are sufficiently representative and difficult to constitute a reasonable test of adequacy.\nA connectionist network is a fine-grained parallel distributed processing configuration, in which simple processing elements are interconnected by scalar links. A connectionist network model for speech recognition has been defined called the temporal flow model. The model incorporates link propagation delay and internal feedback to express temporal relationships. The model is contrasted with other connectionist models in which time is represented explicitly by separate processing elements for each time sample.\nIt has been shown previously that temporal flow models can be 'trained' to perform successfully some speech recognition tasks. A method of 'learning' using techniques of numerical nonlinear optimization has been demonstrated. Methods for extending these results to the problems selected for this research are presented.
Ultrafine ferroelectric nanostructure in layered Mg:LiNbO3 thin film (2015)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text T. Okada, M. Shimizu, S. Horikawa, T. Utsugida, K. Fujii, S. Kurimura, and H. Nakajima, "Ultrafine ferroelectric nanostructure in layered Mg:LiNbO3 thin film," in CLEO: 2015, OSA Technical Digest (online) (Optica Publishing Group, 2015), paper SM1G.2. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article