gebhart/patrepeval huggingface dataset:
Advancements in Industrial Cyber-Physical Systems: An Overview and Perspectives (2022)

Cyber-physical systems (CPSs) have attracted increasing attention in recent years due to their promise for substantial and long-term benefits to society, economy, environment, and citizens. In addition, the rapid advances in computing, communication, and storage technologies have resulted in a revolution in the information communication technology domain and domination in the industry context. The utilization of CPSs in industrial settings has led to industrial cyber-physical systems (ICPSs), which, in conjunction with the information-driven interactions, enables large-scale cooperation in industrial facilities and among all the stakeholders of the value chain. Hence, the research on ICPSs is essential, especially with respect to the engineering of such systems for industrial applications. This article presents an overview of recent developments in ICPSs. We first introduce the architecture of ICPSs. Then, we review the developments of ICPSs in relevant research domains. Finally, this article concludes by presenting some potential future research directions on ICPSs.
Preventing Abuse of Cookies Stolen by XSS (2013)

Cross Site Scripting (XSS) makes victims execute an arbitrary script and leaks out personal information from victims' computers. An adversary can easily get victim's cookies by the XSS attack. If the adversary cannot use the stolen cookies to impersonate the victim, stealing cookie has no meaning. Therefore, we propose a method to prohibit the abuse of stolen cookies in order to make it ineffective to steal cookies through the XXS attack. The proposed method uses one-time password and challenge-response authentication to identify whether a person is a valid owner of the cookie or not.
5-Amino-5-deoxy-2-C-hydroxymethyl-2,3-O-isopropylidene-L-lyxono-1,5-lactam (2007)

The relative configuration of the title compound, C 9 H 14 NO 5 , formed by catalytic hydrogenation of an azidolactone, has been established by X-ray crystallographic analysis. The absolute configuration was determined by the use of 2,3- O -isopropylidene-L-lyxono-1,4-lactone as the carbohydrate starting material.
Involvement of Cyclin D3, CDKN1A (p21), and BIRC5 (Survivin) in Interleukin 11 Stimulation of Decidualization in Mice1 (2007)

Interleukin 11 receptor alpha (Il11ra) null mice are infertile due to defective decidualization and abnormal trophoblast invasion. We have previously shown in these mice that downregulation of decidual proteinase inhibitors plays a role in uncontrolled trophoblast invasion. However, the decidua is abnormally smaller in pseudopregnant Il11ra null mice, where trophoblast invasion is not a factor. Here, we examined whether defective decidualization is due to dysregulation of key molecules involved in decidual cell growth and differentiation. We found a dramatic downregulation of cyclin D3 in Il11ra null mice. We also found that IL11 robustly stimulates the expression of cyclin D3 in cell culture. CDK4 and CDK6, known partners of cyclin D3, are not affected. Immunolocalization studies show absence of cyclin D3 in the mesometrial site and absence of differentiated polyploid cells in the antimesometrial site of Il11ra null mice. We also examined the expression of cell differentiation factors CDKN1A (p21) and CDKN1B (p27), and found that in both in vivo and cell culture the expression of CDKN1A (p21) but not CDKN1B (p27) is under the control of IL11. Another clear target of IL11 in the decidua is BIRC5 (Survivin), whose expression is repressed in the decidua of Il11ra null mice and stimulated by IL11 in cell culture. Taken together, these results provide, at least in part, an explanation for the defective small decidua of mice lacking the Il11ra gene, and reveal for the first time that cyclin D3, CDKN1A (p21), and BIRC5 (Survivin) are targets of IL11 in the decidua.
Blind signal recovery for high rate CDMA systems (2002)

In this paper, the problem of signal recovery in frequency selective channels of CDMA systems is considered. Two blind algorithms based on second-order statistics (SOS) are developed to recover the signal for two scenarios in CDMA systems. Since the proposed algorithms only require the knowledge of the spreading code(s), systems adopting this algorithm may achieve higher efficiency than those adopting non-blind algorithms where a training sequence is needed. Moreover the proposed algorithms do not utilize the information of signal subspace and noise subspace, therefore are more robust to the errors of channel order estimation than conventional SOS algorithms. Simulation results are presented to show the performances of these algorithms and the improvement over an existing SOS algorithm.
Implementation of Robust Nickel Alloy Salicide Process for High-Performance 65nm SOI CMOS Manufacturing (2007)

Addition of Pt to Ni silicide produces a robust [Ni <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> Pt <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">(1-x)</sub> ]Si, which shows an improved morphological stability, an important reduction in encroachment defect density, a reduced tendency to form NiSi <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and significant variations in monosilicide texture without degrading the device performance or the yield of high-performance 65 nm SOI technologies.
Tenascins and their implications in diseases and tissue mechanics (2009)

Tenascins are glycoproteins found in the extracellular matrix (ECM) of many tissues. Their role is not only to support the tissue structurally but also to regulate the fate of the different cell types populating the ECM. For instance, tenascins are required when active tissue modeling during embryogenesis or re-modeling after injury occurs. Interestingly, the four members of the tenascin family, tenascin-C, -X, -R and -W, show different and often mutually exclusive expression patterns. As a consequence, these structurally related proteins display distinct functions and are associated with distinct pathologies. The present review aims at presenting the four members of the tenascin family with respect to their structure, expression patterns and implications in diseases and tissue mechanics.
Stimulated-emission cross sections of the ^5F_1–^5I_5 and ^5F_1–^5I_6 transitions of Pm^3+ in a phosphate glass (1989)

We report a laser cavity measurement of stimulated-emission cross sections for both the 5F1–5I5 (0.93-μm) and 5F1–5I6 (1.1-μm) laser transitions of Pm3+ ions in a lead–indium–phosphate glass host. The measured cross sections for these two transitions are 1.8 × 10−20 (±11%) and 2.8 × 10−20 cm2 (±22%), respectively. These values agree with previously reported values based on a Judd–Ofelt-type analysis of spectroscopic data.
Catalytic asymmetric hydroamination of unactivated internal olefins to aliphatic amines (2015)

Catalytic assembly of enantiopure aliphatic amines from abundant and readily available precursors has long been recognized as a paramount challenge in synthetic chemistry. Here, we describe a mild and general copper-catalyzed hydroamination that effectively converts unactivated internal olefins—an important yet unexploited class of abundant feedstock chemicals—into highly enantioenriched α-branched amines (≥96% enantiomeric excess) featuring two minimally differentiated aliphatic substituents. This method provides a powerful means to access a broad range of advanced, highly functionalized enantioenriched amines of interest in pharmaceutical research and other areas.
Minocycline-induced renal polyarteritis nodosa (2012)

Minocycline is a bacteriostatic, long-acting, lipid-soluble tetracycline that is generally well tolerated, but has been associated with polyarteritis nodosa (PAN). This is a case report of a 21-year-old woman presented to her primary care physician with several months of fatigue, mylagias, weight loss and intermittent severe bi-temporal headaches without changes in vision. Her medications included an Ortho-Tri-Cyclen Lo and Minocycline, which she started 2 years prior for acne. On presentation, she was tachycardic and severely hypertensive. Initial laboratory evaluation showed hyponatraemia and hypokalaemia as well as elevation of inflammatory markers. Autoimmune work-up was positive for perinuclear antineutrophil cytoplasmic antibodies. Renal arteriogram was characteristic of PAN and along with her other symptoms, she fulfilled the necessary criteria of American College of Rheumatology for diagnosis of PAN. Minocycline as a possible causative agent was discontinued since it was reported to cause cutaneous PAN in the literature. Cyclophosphamide and prednisone were initiated for treatment of her vasulculitis. Her symptoms and hypertension improved over the next several months. This is the first report of the minocycline-induced renal PAN.
Opsonin-free, real-time imaging of Cryptococcus neoformans capsule during budding (2018)

Cryptococcus neoformans is a unicellular fungal pathogen that causes meningoencephalitis, killing hundreds of thousands of patients each year. Its most distinctive characteristic is a polysaccharide capsule that envelops the whole cell. It is the major virulence attribute and the antigen for serologic diagnosis. We have developed a method for easy observation of the capsule and its growth dynamics using the cell-separation reagent Percoll and differential interference contrast (DIC) microscopy. Percoll suspension is far less disruptive of cell physiology than methods relying on antibody binding to the capsule, and measurements made with it are equivalent with India ink. Time-lapse microscopy observations using this method suggest that during budding, a dividing cell can regulate whether the capsule polysaccharide it produces is deposited on the capsule of the bud or on its own. This observation has important implications for our understanding of the C. neoformans capsule induction process during budding.
Feedback phase-shift compensation for adaptiveinterference cancellers (2000)

An algorithm typically used for adaptive co-site interference cancellers (for frequency-hopping spread-spectrum communications systems) is the least-mean-square error (LMS) algorithm. As adaptive cancellation moves into L-band and S-band, feedback system stability becomes a critical issue for co-site interference cancellers using the LMS algorithm. The authors present a technique for compensating the high-frequency feedback path phase shifts leading to instability with an additional complex weight multiplication at baseband. Simulation and experimental results confirm the effectiveness of the technique.
Updates on Softwood-to-Ethanol Process Development (2007)

Softwoods are generally considered to be one of the most difficult lignocellulosic feedstocks to hydrolyze to sugars for fermentation, primarily owing to the nature and amount of lignin. If the inhibitory effect of lignin can be significantly reduced, softwoods may become a more useful feedstock for the bioconversion processes. Moreover, strategies developed to reduce problems with softwood lignin may also provide a means to enhance the processing of other lignocellulosic substrates. The Forest Products Biotechnology Group at the University of British Columbia has been developing softwood-to-ethanol processes with SO2-catalyzed steam explosion and ethanol organosolv pretreatments. Lignin from the steam explosion process has relatively low reactivity and, consequently, low product value, compared with the high-value coproduct that can be obtained through organosolv. The technical and economic challenges of both processes are presented, together with suggestions for future process development.
C-Myc Driven Tolerogenic Tumor Microenvironment (TME) in Mantle Cell Lymphoma (MCL) Is Overcome By Bromodomain Inhibition (2018)

Abstract Remarkable clinical efficacy and durable responses to antibodies that block the programmed death-1 (PD-1)-programmed death-ligand 1 (PD-L1) pathway have been observed in patients with multiple cancers, including classical Hodgkin lymphomas (cHL). However, the responses in the majority of Non-Hodgkin lymphoma patients, including mantle cell lymphoma (MCL), treated with anti- PD1/PDL1 antibodies have been modest to date. It has been postulated that the immune suppressive nature of the tumor microenvironment (TME) may play a role in limiting the efficacy of checkpoint blockade strategies. As such, identification of critical molecules in TME required for driving response and resistance is key to improve lymphoma immunotherapy. We have therefore generated in vivo and ex-vivo MCL lymphoma-stroma co-culture models and capitalize this model with primary human MCL cells as well. First, we found that co-injection of murine Fc-muMCL1 cells with stromal cells significantly promote lymphoma growthas compared to Fc-muMCL1 cells injected alone. This aggressive growth was associated with less tumor infiltrating cytotoxic T-cells in the TME. Second, to identify the tolerogenic mechanism(s) that drive immunosuppression in TME, we co-cultured MCL cells with stroma cells ex-vivo and found an increased translation and transcription of PD-L1 via upregulation of c-Myc. Furthermore, co-culture of patient primary lymphoma cells with stromal cell dramatically increases PD-L1 expression in both stromal cells and lymphoma cells. Tumor infiltrating T cells also induce PD-L1 expression in stromal cells. Of note, just by knocking down c-Myc in stromal cell we were able to block co-culture-induced PD-L1 expression, highlighting a critical role for c-Myc in driving this tolerogenic process in the TME. In lieu of the above findings, next we treated murine MCL in vitro with a bromodomain inhibitor (JQ1) and observed a significant decrease in c-Myc/PD-L1 expression which was associated with increased immunogenicity of malignant B-cells leading to a better T-cell activation. More importantly, treatment of MCL-bearing mice with a combination of a bromodomain inhibitor with anti-PD1 antibody resulted in enhanced inhibition of MCL growth, increased effector memory T cells and improved function of tumor infiltrating T cells in vivo. No such effects were observed in MCL-bearing mice treated with either agent alone. Taken together, we have identified the c-Myc/PD-L1 axis in stromal cells that by creating a tolerogenic/immunosuppressive TME imposes a significant barrier to the efficacy of checkpoint blockade therapy in lymphomas. This barrier seems not to be unsurmountable since the addition of a bromodomain inhibitor augmented the efficacy of checkpoint blockade by inducing a more immunogenic TME in MCL. Disclosures No relevant conflicts of interest to declare.
Characterization of subcellular components in synchronized hepatoma cells as a function of the cell cycle (1979)

The specific activity and subcellular distribution of marker enzymes for the main subcellular components were analysed in homogenates of synchronized hepatoma cells (Morris 7288c), obtained by selective detachment at mitosis combined with a metaphase block with Colcemid. Markers for lysosomes, mitochondrial outer membrane, plasma membrane and cytosol are synthesized throughout the cycle at the same rate as the bulk of cellular protein. Larger variations are observed for a Golgi marker; after a decrease around mitosis, the specific activity of galactosyltransferase increases steadily from middle G(1)-phase on, and at the end of G(2)-phase it is nearly twice that observed at the beginning of G(1)-phase. Our results show that synthesis of cytochrome oxidase may occur preferentially in G(2)-phase. Large modifications of the density distribution of lysosomes are observed during the cell cycle; the median equilibrium density of lysosomal markers decreases in G(1)-phase, and some increase in soluble activity occurs at the same time. Reverse changes occur progressively during S- and G(2)-phases. At mitosis, Golgi galactosyltransferase shows a more dispersed distribution, and modifications in the density distribution of endoplasmic-reticulum NADPH-cytochrome c reductase are observed. The latter can be most easily explained by a detachment of ribosomes from endoplasmic-reticulum membranes. No significant modifications occur in mitochondrial and plasma-membrane markers.
Rhenium Complexes with a Photochemically Variable Anthracene Subunit: A Molecular Switch (1997)

A markedly different emission behavior is exhibited by the two rhenium complexes 1 and 2. These can be interconverted photochemically; the forward reaction (cyclization to the “closed” form) is triggered by visible light, and the reverse reaction by UV light. Therefore, this is a photoswitchable molecular system in which the anthracene groups function as the switching unit and the complexed rhenium as the detector.
Dynamic Analysis of Cross Flow Heat Exchangers in Data Centers Using Transient Effectiveness Method (2014)

Heat exchangers are important facilities used in data center cooling systems. The effectiveness of heat exchangers strongly influences the thermal performance of cooling systems. Rear door heat exchangers, in-row, overhead coolers, and fully contained cabinets are some examples of executing liquid and hybrid cooling systems used in data centers. A liquid to liquid heat exchanger is an important component of the coolant distribution unit, which supplies chilled water to the aforementioned heat exchangers. Computer room air handler units are also typically liquid to air cross flow heat exchangers. It is important to characterize the dynamic behavior of these heat exchangers for the thermal management of data centers, to improve the design of control strategies, and energy efficiency. The transient response of a 2-D unmixed-unmixed cross flow heat exchanger, with a finite wall capacitance, is investigated. The transient effectiveness concept is used to build the mathematical models that will be used to solve and analyze the transient problems involving cross flow heat exchangers. Several transient cases are investigated numerically for step, ramp, and exponential variations in the inlet temperature of the minimum capacity rate fluid, as well as step and ramp changes in the flow rate of hot and cold fluids. The transient effectiveness characteristics are tested in parametric studies. The results obtained show that transient effectiveness is a useful method of analyzing and predicting the dynamic performance of cross flow heat exchangers.
Association of ambient air pollution with age-related macular degeneration and retinal thickness in UK Biobank (2021)

Greater exposure to PM<sub>2.5</sub> was associated with self-reported AMD, while PM<sub>2.5</sub>, PM<sub>2.5</sub> absorbance, PM<sub>10</sub>, NO<sub>2</sub> and NO<sub>x</sub> were all associated with differences in retinal layer thickness.
VT arising from sub‐aortic muscular outflow tract structures: In two patients with ventricular septal defects (2019)

In rare instances, a structural variant may be involved in OTVTs. The use of ICE along with electroanatomic mapping can assist in successful ablation of these ventricular tachycardias.
Targeting of Cytolytic T-cells for Breast Cancer Therapy Using Novel-Fusion Proteins (1997)

Abstract : The provision of the T cell costimulatory molecule B7 to tumor cells can be an effective means of triggering a tumor specific cytolytic T cells response. One way to provide B7 to tumor cells would be to couple an anti-tumor antibody either directly to B7 or to an antibody to the B7 counterreceptor on T cells, CD28. To this end, a fusion protein has been developed which incorporates a single chain antibody fragment (scFv) to c-erbB-2 (Her2/neu), an oncogene product overexpressed by 30-50% of breast carcinomas, and the extracellular domain of B7-2 (CD86). Experiments are currently underway to determine if the fusion protein can bind to c-erbB-2 and CD28, and also to measure its ability to activate T-cells. In addition, single chain antibody fragments are currently being selected, using a phage display scFv library, which are specific for the T cell costimulatory receptor molecule CD28. Anti-CD28 scFv with a range of affinities will be isolated and the role of affinity and differential binding to T cell costimulatory receptors will be determined to identify their importance in the biology of T cell activation.
Self-Contained CMOS SOI Power Amplifier for 5G Mobile Communications (2017)

International audience
High-performance capillary electrophoresis biosignature analysis under micro- and hyper-gravity conditions using a flight-format Microfluidic Organic Analyzer (MOA) (2023)

Abstract The development of organic biosignature analysis instruments with a high detection sensitivity is critical for exploring our solar system for habitability and for organic chemical biomarkers. In particular, the Microfluidic Organic Analyzer (MOA) has been developed in a compact, low-mass, space-flight compatible format to address this goal. To demonstrate the performance of the matured MOA instrument, we performed a series of five Zero-G parabolic aircraft flights to test the MOA microfluidic, capillary electrophoresis (CE) separation, and detection systems in micro- and hyper-gravity environments. Amino acid CE separations were performed in flight to develop the protocols and to determine the dependence of the separation quality on large variations in gravitational potential. We present here an amino acid separation performed as the gravitational potential varied from 0.16 to 1.7 g during the separation. The amino acid separation is essentially indistinguishable from separations performed in a constant 1 g environmental control. This work advances the technology readiness of microfabricated CE systems for planetary biosignature detection and enhances our preparedness for future flights.
A Multi-Layer Distributed Development Environment for Mobile Robotics (1993)

Mobile robotic devices combining sensors, actuators, and computers are unique, complex devices which may be difficult to model from an abstract point of view. This paper presents a software development system which builds an abstraction of a robotic environment. This abstraction allows external software to interact with either a simulated robot and environment or to a real robot complete with sensors. The implementation is distributed across a network, and allows software to run on remote hardware thus taking advantage of any specialized hardware available on the network.
Intestinal Ralstonia pickettii augments glucose intolerance in obesity (2017)

An altered intestinal microbiota composition has been implicated in the pathogenesis of metabolic disease including obesity and type 2 diabetes mellitus (T2DM). Low grade inflammation, potentially initiated by the intestinal microbiota, has been suggested to be a driving force in the development of insulin resistance in obesity. Here, we report that bacterial DNA is present in mesenteric adipose tissue of obese but otherwise healthy human subjects. Pyrosequencing of bacterial 16S rRNA genes revealed that DNA from the Gram-negative species Ralstonia was most prevalent. Interestingly, fecal abundance of Ralstonia pickettii was increased in obese subjects with pre-diabetes and T2DM. To assess if R. pickettii was causally involved in development of obesity and T2DM, we performed a proof-of-concept study in diet-induced obese (DIO) mice. Compared to vehicle-treated control mice, R. pickettii-treated DIO mice had reduced glucose tolerance. In addition, circulating levels of endotoxin were increased in R. pickettii-treated mice. In conclusion, this study suggests that intestinal Ralstonia is increased in obese human subjects with T2DM and reciprocally worsens glucose tolerance in DIO mice.