gebhart/patrepeval huggingface dataset:
Perception of a conserved family of plant signalling peptides by the receptor kinase HSL3 (2021)

Abstract Plant genomes encode hundreds of secreted peptides; however, relatively few have been characterised. We report here an uncharacterised, stress-induced family of plant signalling peptides, which we call CTNIPs. Based on the role of the common co-receptor BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) in CTNIP-induced responses, we identified the orphan receptor kinase HAESA-LIKE 3 (HSL3) as the CTNIP receptor via a proteomics approach. CTNIP binding, ligand-triggered complex formation with BAK1, and induced downstream responses all involve HSL3. Notably, the HSL3-CTNIP signalling module is evolutionarily ancient, predating the divergence of extant angiosperms. The identification of this signalling module will help establish its physiological role and provides a resource to understand further receptor-ligand co-evolution.
A New Concept of a Two-Dimensional Supersonic Relative Inlet Mach Number Compressor Cascade (2009)

In this study, a numerical shape optimization method based on evolutionary algorithms coupled with a verified CFD solver has been applied to the ambitious target of a shock free 2-D supersonic inlet Mach number compressor cascade. The study is based on the DLR-PAV-1.5 supersonic compressor cascade designed by the pre-compression blading concept. The DLR cascade airfoil has been optimized using a verified CFD code. A superior performance of the optimized supersonic cascade with about 24% reduction of the total pressure loss coefficient compared to the original cascade has been realized. The flow mechanisms observable around the blade with improved performance and the resulting design concept are discussed in this paper.
Performance and application of high-power ultraviolet AlGaInN light-emitting diodes (2004)

We report on high output power from the quaternary AlGaInN multiple quantum well (MQW) ultraviolet light emitting diodes (UV LEDs) in the 340 nm and 280 nm wavelength range. The output power up to 1.5 mW from a 100 &mu;m diameter device with bare-chip configuration was measured under room temperature cw operation. The internal quantum efficiency was estimated to be between 7 and 10%. In addition, the output power and external quantum efficiency for fully packaged 1x1mm<sup>2</sup> large area device were as high as 54.6 mW and 1.45%, respectively, at the injection current of 200 A/cm<sup>2</sup> under pulsed operation. The devices were incorporated into prototype system for fluorescence based bio-sensing. We also report the performance of 285 nm UV LEDs.
Fabrication of thermally stable and cost-effective polymeric waveguide for optical printed-circuit board (2008)

A thermally stable polymeric optical waveguide has been fabricated using ultraviolet (UV)-curable epoxy resins for the core and clad materials. A simple and cost-effective fabrication method that uses reusable polydimethylsiloxane (PDMS) masters has been developed. The 12-channel under-clad layer of the UV-cured epoxy was prepared using a PDMS master whose embossed channels had been fabricated by a polycarbonate (PC) secondary master. The thermal stability of the fabricated waveguide was tested at 200 degrees C for one hour. The optical waveguide was not damaged physically by thermal stress. Propagation losses detected by a cut-back method were 0.16 dB/cm and 0.26 dB/cm, respectively, before and after the thermal stability test at 850 nm. Loss increase after the thermal treatment can be attributed to the formation of the absorbing and scattering sources. This waveguide can be applied for areas that require thermal stability such as an optical printed-circuit board.
An RNA Aptamer Targeting the Receptor Tyrosine Kinase PDGFRα Induces Anti-tumor Effects through STAT3 and p53 in Glioblastoma (2018)

Human glioblastoma (GBM) is the most aggressive malignancy of the CNS, with less than 5% survival. Despite great efforts to find effective therapeutics, current options remain very limited. To develop a targeted cancer therapeutic, we selected RNA aptamers against platelet-derived growth factor receptor α (PDGFRα), which is a receptor tyrosine kinase. One RNA aptamer (PDR3) with high affinity (0.25 nM) showed PDGFRα specificity and was internalized in U251-MG cells. Following treatment with the PDR3 aptamer, expression of the transcription factor STAT3 (signal transducer and activator of transcription 3) was inhibited, whereas the expression of the histone demethylase JMJD3 and the tumor suppressor p53 were upregulated. PDR3 also upregulated serine phosphorylation of p53, which subsequently mediated apoptosis through the death receptors: tumor necrosis factor (TNF)-related apoptosis-inducing ligand receptors 1/2 (TRAIL-R1/R2), Fas-associated via death domain (FADD), and Fas. PDR3 significantly decreased cell viability in a dose-dependent manner. Furthermore, translocation of PDR3 into the nucleus induced hypomethylation at the promoters of cyclin D2. To assess the feasibility of targeted delivery, we conjugated PDR3 aptamer with STAT3-siRNA for a chimera. The PDR3-siSTAT3 chimera successfully inhibited the expression of target genes and showed significant inhibition of cell viability. In summary, our results show that well-tailored RNA aptamers targeting the PDGFRα-STAT3 axis have the potential to act as anti-cancer therapeutics in GBM.
An in-vehicle communication scheme for multi-system integration (2013)

With more and more devices being introduced into vehicles to provide additional driving functionality, driving experience is seemingly getting more complex and frustrated due to an influx of individual messages. To help manage the information, we need a mechanism to orchestrate the operations of the in-vehicle devices so that such frustration can be eased. In this study, we propose an in-vehicle communication scheme for multi-system integration, where an effective system service discovery protocol is used. This proposed design also contains mutual communication methods and the data exchange methodologies for system integration. Experimental results with data analysis demonstrate the success of the proposed design.
Pulmonary function and structure abnormalities in children and young adults with osteogenesis imperfecta point to intrinsic and extrinsic lung abnormalities (2023)

NCT03575221.
Charge transport properties in electrically aged organic light-emitting diodes (2013)

Organic light-emitting diodes (OLEDs) are a rapidly developing technology with high innovation potential for displays, lighting, and further applications. Critical issues for current research remain the extension of lifetimes and, related to this aim, a deeper understanding of degradation processes in OLEDs. In the present work, we used the charge-based deep level transient spectroscopy technique to investigate changes in the charge transport in OLEDs induced by electrical aging. Both trap states capturing electrons and holes, respectively, were detected. Temperature-dependent measurements enabled estimating the depth of the trap states for electrons. Comparison of spectra of electrically aged and undriven devices revealed that aging seemed to increase the density of traps but did not lead to the occurrence of new types of trap states. Furthermore, experiments with different voltage pulses to fill the charge carrier trap states allowed conclusions on age-induced changes of the injection barrier for holes.
Incorporation of Unnatural Amino Acids into Cytochrome c3 and Specific Viologen Binding to the Unnatural Amino Acid (2006)

Getting to heme. A system for the incorporation of unnatural amino acid into cytochrome c3 by site-specific viologen modification has been established. A viologen was linked to the side chain of the unnatural amino acid, and cytochrome c3 accepted an electron through the linked viologen. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2268/2006/z600347_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Characterization of the Antibody Response to Pneumococcal Glycoconjugates and the Effect of Heat‐Labile Enterotoxin on IgG Subclasses after Intranasal Immunization (2001)

The antibody response to pneumococcal glycoconjugate (Pnc) was characterized by analyzing pneumococcal polysaccharide (PPS)-- and protein carrier-specific IgG subclass profiles and their relationship. Mice were immunized intranasally (inl) or subcutaneously (sc) with Pnc with mutants of Escherichia coli heat-labile enterotoxin, LT-R72 and LT-K63, as mucosal adjuvants. Subcutaneous immunization with Pnc alone induced predominantly IgG1, whereas native PPS administered sc induced very low IgG titers that were exclusively of the IgG3 subclass. Compared with sc immunization with Pnc alone, inl immunization with Pnc and LT mutants induced significantly higher systemic IgG2a, IgG3, and IgA antibodies to both PPS and the carrier, whereas the IgG1 titers were comparable. There also was a significant correlation between PPS- and protein carrier--specific antibody responses for all IgG subclasses. This demonstrates that LT mutants can be used to both enhance and modulate the antibody response to the PS moiety of glycoconjugate vaccines.
The negatively charged carboxy-terminal tail of β-tubulin promotes proper chromosome segregation (2016)

Despite the broadly conserved role of microtubules in chromosome segregation, we have a limited understanding of how molecular features of tubulin proteins contribute to the underlying mechanisms. Here we investigate the negatively charged carboxy-terminal tail domains (CTTs) of α- and β-tubulins, using a series of mutants that alter or ablate CTTs in budding yeast. We find that ablating β-CTT causes elevated rates of chromosome loss and cell cycle delay. Complementary live-cell imaging and electron tomography show that β-CTT is necessary to properly position kinetochores and organize microtubules within the assembling spindle. We identify a minimal region of negatively charged amino acids that is necessary and sufficient for proper chromosome segregation and provide evidence that this function may be conserved across species. Our results provide the first in vivo evidence of a specific role for tubulin CTTs in chromosome segregation. We propose that β-CTT promotes the ordered segregation of chromosomes by stabilizing the spindle and contributing to forces that move chromosomes toward the spindle poles.
Strategies Based on Nitride Materials Chemistry to Stabilize Li Metal Anode (2017)

Lithium metal battery is a promising candidate for high-energy-density energy storage. Unfortunately, the strongly reducing nature of lithium metal has been an outstanding challenge causing poor stability and low coulombic efficiency in lithium batteries. For decades, there are significant research efforts to stabilize lithium metal anode. However, such efforts are greatly impeded by the lack of knowledge about lithium-stable materials chemistry. So far, only a few materials are known to be stable against Li metal. To resolve this outstanding challenge, lithium-stable materials have been uncovered out of chemistry across the periodic table using first-principles calculations based on large materials database. It is found that most oxides, sulfides, and halides, commonly studied as protection materials, are reduced by lithium metal due to the reduction of metal cations. It is discovered that nitride anion chemistry exhibits unique stability against Li metal, which is either thermodynamically intrinsic or a result of stable passivation. The results here establish essential guidelines for selecting, designing, and discovering materials for lithium metal protection, and propose multiple novel strategies of using nitride materials and high nitrogen doping to form stable solid-electrolyte-interphase for lithium metal anode, paving the way for high-energy rechargeable lithium batteries.
Supplemental Data: Using Portable Transducers to Measure Tremor Severity (2016)

Background: Portable motion transducers, suitable for measuring tremor, are now available at a reasonable cost. The use of these transducers requires knowledge of their limitations and data analysis. The purpose of this review is to provide a practical overview and example software for using portable motion transducers in the quantification of tremor. Methods: Medline was searched via PubMed.gov in December 2015 using the Boolean expression ‘‘tremor AND (accelerometer OR accelerometry OR gyroscope OR inertial measurement unit OR digitizing tablet OR transducer).’’ Abstracts of 419 papers dating back to 1964 were reviewed for relevant portable transducers and methods of tremor analysis, and 105 papers written in English were reviewed in detail. Results: Accelerometers, gyroscopes, and digitizing tablets are used most commonly, but few are sold for the purpose of measuring tremor. Consequently, most software for tremor analysis is developed by the user. Wearable transducers are capable of recording tremor continuously, in the absence of a clinician. Tremor amplitude, frequency, and occurrence (percentage of time with tremor) can be computed. Tremor amplitude and occurrence correlate strongly with clinical ratings of tremor severity. Discussion: Transducers provide measurements of tremor amplitude that are objective, precise, and valid, but the precision and accuracy of transducers are mitigated by natural variability in tremor amplitude. This variability is so great that the minimum detectable change in amplitude, exceeding random variability, is comparable for scales and transducers. Research is needed to determine the feasibility of detecting smaller change using averaged data from continuous long-term recordings with wearable transducers.
A History of Private Life: III. Passions of the Renaissance. Edited by Roger Chartier, translated by Arthur Goldhammer. (Philippe Aries and Georges Duby, general editors.) (Cambridge: Harvard University Press, 1989, pp. 645. $39.50) (1990)

Journal Article A History of Private Life: III. Passions of the Renaissance. Edited by Roger Chartier, translated by Arthur Goldhammer. (Philippe Ariès and Georges Duby, general editors.) (Cambridge: Harvard University Press, 1989, pp. 645. $39.50) Get access Lawrence Wolff Lawrence Wolff Boston College Search for other works by this author on: Oxford Academic Google Scholar Journal of Social History, Volume 24, Issue 2, Winter 1990, Pages 404–406, https://doi.org/10.1353/jsh/24.2.404 Published: 01 December 1990
Dynamic selection of application-specific garbage collectors (2004)

Much prior work has shown that the performance enabled by garbage collection (GC) systems is highly dependent upon the behavior of the application as well as on the available resources. That is, no single GC enables the best performance for all programs and all heap sizes. To address this limitation, we present the design, implementation, and empirical evaluation of a novel Java Virtual Machine (JVM) extension that facilitates dynamic switching between a number of very different and popular garbage collectors. We also show how to exploit this functionality using annotation-guided GC selection and evaluate the system using a large number of benchmarks. In addition, we implement and evaluate a simple heuristic to investigate the efficacy of switching automatically. Our results show that, on average, our annotation-guided system introduces less than 4% overhead and improves performance by 24% over the worst-performing GC (across heap sizes) and by 7% over always using the popular Generational/Mark-Sweep hybrid.
Experimental study of light output power for vertical GaN-based light-emitting diodes with various textured surface and thickness of GaN layer (2012)

The light output power (LOP) of vertical-type GaN-based light emitting diodes (LED) with surface roughness (texture) can be changed by texture size, density, and thickness of GaN film or by the combined effects of texture formation and thickness of GaN film. We have investigated these changes experimentally and note that the enhancement of the LOP by a factor of 2.4 can be improved with optimum texturing parameters as compared to that without texturing. In addition, the LOP of GaN-based LEDs under the same texture density increase slightly as thickness of GaN film decreases. Base on these results, we have evidently demonstrated that the enhancement factors of LOP are related to the correlation between texture size (density) and thickness of GaN film.
Persistent memcached: bringing legacy code to byte-addressable persistent memory (2017)

We report our experience building and evaluating pmemcached, a version of memcached ported to byte-addressable persistent memory. Persistent memory is expected to not only improve overall performance of applications' persistence tier, but also vastly reduce the time needed for applications after a restart. We decided to test this hypothesis on memcached, a popular key-value store. We took the extreme view of persisting memcached's entire state, resulting in a virtually instantaneous warm up phase. Since memcached is already optimized for DRAM, we expected our port to be a straightforward engineering effort. However, the effort turned out to be surprisingly complex during which we encountered several non-trivial problems that challenged the boundaries of memcached's architecture. We detail these experiences and corresponding lessons learned.
Cover Feature: Magnetism and Afterglow United: Synthesis of Novel Double Core–Shell Eu2+‐Doped Bifunctional Nanoparticles (Chem. Eur. J. 30/2020) (2020)

Magnetic/afterglow bifunctional nanoparticles are presented for the first time in this work. These afterglow-magnetic nanoparticles (NPs) offer an enormous potential for bioimaging applications, since they can be manipulated by a magnetic field, besides emitting light after the irradiation with an excitation source, distinguishing themselves from fluorescent living cells. More information can be found in the Full Paper by C. Wickleder et al. on page 6833.
Effect of silage type and concentrate level on conjugated linoleic acids, trans-C18:1 isomers and fat content in milk from dairy cows (2006)

The objective of the study was to examine how the fatty acid composition of milk especially concentrations of conjugated linoleic acids (CLA) and trans-C18:1 isomers and milk fat percentage were affected by silage type and concentrate level. Forty dairy cows were blocked and randomly assigned to one of four diets in a 2 x 2 factorial arrangement of treatments and a six week experimental period. Treatments were total mixed rations with maize (M) or grass (G) silage differing in polyunsaturated fatty acid (PUFA) profile and starch content, combined with a high (H) or a low (L) level of concentrate (with or without grain). Treatments had no significant effect on milk, protein and lactose yield, but energy corrected milk yield, milk fat percentage and fat yield was lower and protein percentage higher for maize compared with grass silage diets. Overall, maize silage diets resulted in higher concentrations of CLA isomers compared with grass silage diets, but there was a significant interaction between silage type and concentrate level for concentrations of cis9,trans11-CLA; trans10,cis12-CLA; trans11-C18:1 and trans10-C18:1. A high level of concentrate increased trans10,cis12-CLA and trans10-C18:1 and reduced cis9,trans11-CLA and trans11-C18:1 when maize but not grass silage was provided. The results suggest that high levels of concentrate (grain) do not significantly alter the pattern of PUFA biohydrogenation in the rumen, the concentration of CLA and trans-C18:1 isomers in milk or cause milk fat depression unless combined with forage naturally high in starch and C18:2n-6 such as maize silage.
Complete nucleotide sequence and genome organization of a Drosophilatransposable genetic element, 297 (1986)

The complete nucleotide sequence of 297, a Drosophila copia-like transposable element, was determined and compared with those of other similar Drosophila elements and mammalian retrovirus proviruses. It was found that 297 contains three long open reading frames, comparable in sizes and locations with gag, pol, and env genes in the proviruses of replication-competent retroviruses in vertebrates. The first and second open reading frames of 297 exhibit sequence homologies to gag and pol, respectively, of Moloney murine leukaemia virus. In particular, as with 17.6, another Drosophila copia-like element, the second open reading frame of 297 was shown to be very similar in its entire organization to the retroviral pol gene and to consist of three enzymatic domains. By contrast, no appreciable homology was found between the third open reading frame of 297 and the retroviral env gene. It is also suggested that 297 and 17.6 are a peculiar pair of copia-like elements recently diverged from a common progenitor.
Room Temperature Aryl Trifluoromethylation via Copper- Mediated Oxidative Cross-Coupling (2011)

A method for the room temperature copper-mediated trifluoromethylation of aryl and heteroaryl boronic acids has been developed. This protocol is amenable to normal benchtop setup and reactions typically require only 1−4 h. Proceeding under mild conditions, the method tolerates a range of functional groups, allowing access to a variety of trifluoromethylarenes.
Pelletization (2016)

This Glossary of Terms Related to Pharmaceutics is needed by practitioners in the field of pharmaceutics as this field fulfills an important and crucial role, different from the roles of other scientific disciplines involved in the drugmaking process. The glossary contains 168 definitions used in pharmaceutics. These are related to various aspects of this discipline, such as: (1) physicochemical characterization of pharmaceutical preparations and the active ingredients they contain; (2) unit operations used in the practice of pharmaceutics; (3) terms related to the various dosage forms; (4) terms related to the various modes and routes of drug delivery; (5) terms used in pharmacokinetics and biopharmaceutics in general; and additional miscellaneous terms. The field of pharmaceutics itself is of a multidisciplinary nature as its practitioners come from a variety of disciplines, such as chemistry or various biological sciences, thus a glossary containing authoritative definitions would be useful for them. The terms used in pharmaceutics are rarely covered by existing glossaries, and in the cases they are, their definitions are often inappropriate for the field of pharmaceutics and require new or modified definitions to better fit the new context.
Fiber optic illumination systems (1990)

A basic element of a machine vision system is the corresponding illumination system.
The price or even the feasibility of a machine vision system depends siginuicantly on the quality
of the image and the image itself is directly Influenced by the illumination quality of the object
(intensity, Intensity distribution, size, etc.).
Fiber optic illumination components are very suitable as illumination elements because they are
flexible, robust, they need only few adjusting elements and provide therefore easy means for well
defined and controlled illumination situations.
The very first step in a machine vision project is the image creation process. A good knowledge
of the illumination problems and the properties of illumination components helps to create an
optimal image and this in turn gives the opportunity to keep the image analysis system (hardand
software) as simple as possible.
While the classical way to create a good image is the illumination experiment, there are methods
to do a simulation of fiber optic components and to calculate the influence of design parameters
on the illumination distributions. This helps to predefine illumination parameters before creating
any hardware for illumination.