gebhart/patrepeval huggingface dataset:
Stem Cells in Vascular Tissue Engineering (2007)

Recent studies have shown it is possible to successfully engineer vessels with excellent mechanical strength in bovine, porcine, and canine systems, using differentiated vascular cells. However, translating vascular engineering techniques from animal cells to human vascular cells has met with some difficulties. Based in part upon these observations, it seems reasonable to seek alternative cell sources that may be suitable for vessel engineering. Human stem and progenitor cells have been isolated from a wide range of sources. Their autologous origin, high proliferative capacity and potential to differentiate into vascular phenotypes have generated significant attention. Mesenchymal stem cells (MSC) are variously defined as multipotent adult stem cells that are present in the bone marrow. The ability of MSCs to differentiate into three types of myocytes has been shown previously. In order to investigate whether human bone marrow‐derived MSCs can directly differentiate into functional vascular smooth muscle, vessel walls were engineered using human bone marrow‐derived MSCs in a biomimetic culture system in vitro. The cultured cells and the engineered vessel wall expressed specific markers for smooth muscle, and synthesized collagen. Various approaches, including gene therapy, were also explored for their efficiency in inducing highly differentiated smooth muscle from MSC.
Photoresponse and conductance mechanisms in nanoscale superconductor normal-metal point contacts (1998)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 1998.
Enhancing electrochemical methods for producing and regenerating alane by using electrochemical catalytic additive (2023)

A process of using an electrochemical cell to generate aluminum hydride (AlH.sub.3) and other high capacity hydrides is provided. The electrolytic cell uses an electro-catalytic-additive within a polar non-salt containing solvent to solubilize an ionic hydride such as NaAlH.sub.4 or LiAlH.sub.4. The resulting electrochemical process results in the formation of AlH.sub.3 adduct. AlH.sub.3 is obtained from the adduct by heating under vacuum. The AlH.sub.3 can be recovered and used as a source of hydrogen for the automotive industry. The resulting spent aluminum can be regenerated into NaAlH.sub.4 or LiAlH.sub.4 as part of a closed loop process of AlH.sub.3 generation.
Design Philosophy of Restroom Cleaning Competition (2023)

Cleaning toilets is physically and mentally demanding, and in convenience stores where food is handled, it is undesirable for clerks to perform this work from a hygiene perspective; however, it is difficult to automate the task. To enhance the technology and address this challenge, restroom cleaning competitions have been conducted since 2017. The participants are challenged to clean simulated urine and garbage using their robot system. This paper describes the design philosophy and findings of this competition.
Normoxic Lung Ischemia/Reperfusion Accelerates Shedding of Angiotensin Converting Enzyme from the Pulmonary Endothelium (1997)

Normoxic lung ischemia/reperfusion (I/R) leads to oxidative injury of the pulmonary tissue. We analyzed angiotensin-converting enzyme (ACE) in perfused rat lungs upon I/R in order to assess the endothelial injury produced. I/R led to a time-dependent increase in ACE activity in the perfusate, from 145+/-14 mU to 252+/-1 mU, and to reduction of ACE activity in the lung tissue homogenate, from 29.7+/-2.3 U to 22.7+/-1.7 U. About 80% of ACE activity in control and I/R rat lungs was associated with an aqueous phase of extracted perfusates, thus indicating that I/R accelerates shedding of the hydrophilic form of ACE from the plasma membrane. To specifically assess ACE localized on the luminal surface of the pulmonary endothelium, we perfused rat lungs with a radiolabeled monoclonal antibody (mAb) to ACE (anti-ACE mAb 9B9). Pulmonary uptake of mAb 9B9 with I/R was reduced from 32.1+/-1.7% to 24.8+/-0.9%. In contrast, I/R led to a marked increase in the pulmonary uptake of nonspecific [125I]IgG, from 0.17+/-0.02% to 0.67+/-0.04%. Lung wet weight was equal to 0.78+/-0.08% of body weight in the I/R group versus 0.57+/-0.02% at the control level. The observed increase in [125I]IgG uptake and wet lung weight indicate that I/R causes an increase in lung vascular permeability. These results indicate that normoxic lung I/R induces injury to the pulmonary vascular endothelium.
CORMs protect endothelial cells during cold preservation, resulting in inhibition of intimal hyperplasia after aorta transplantation in rats (2010)

Allograft vasculopathy is the leading cause for chronic transplant loss. We investigated if the addition of carbon monoxide releasing molecules (CORMs) to the preservation solution would protect the endothelium from cold preservation injury in an aortic transplantation model. In particular, we tested if CORM preserve vascular functioning and limit neo-intima formation following cold preservation (Cp). Abdominal aortas from Lewis or Fisher rats were subjected to Cp in University of Wisconsin (UW) solution to which 50 μm of CORM-3 was added or not. Hereafter, whole mount staining, acetylcholine mediated vasorelaxation (AMV) and aortic transplantation was performed. In vitro CORM-3 protected human umbilical vein endothelial cells from Cp injury and prevented denudation and intercellular gap formation in aortic grafts. Cp resulted in loss of AMV of aorta segments. By contrast, AMV was preserved after the addition of CORM-3 during Cp. Two months after transplantation Cp of aorta grafts resulted in an increased adventitial remodelling and neo-intima formation. This was significantly blunted by CORM-3 in syngeneic recipients. Our study demonstrates that addition of CORM-3 to UW solution prevents endothelial damage, thereby maintaining vascular function directly after cold preservation. Hence, our findings might offer a novel strategy to prevent vascular damage during CP.
Evaluation of 70/30 D,L-PLa for Use as a Resorbable Interbody Fusion Cage (2002)

Titanium lumbar interbody spinal fusion devices are reported to be 90% effective for single-level lumbar interbody fusion, although radiographic determination of fusion has been debated. Using blinded radiographic, biomechanic, histologic, and statistical measures, researchers in the present study evaluated a radiolucent 70/30 poly(L-lactide-co-D,L-lactide) (70/30 D,L-PLa) interbody fusion device packed with autograft or rhBMP-2 on a collagen sponge in 25 sheep at 3, 6, 12, 18, and 24 months. A trend of increased fusion stiffness, radiographic fusion, and histologic fusion was demonstrated from 3 months to 24 months. Device degradation was associated with a mild to moderate chronic inflammatory response at all postoperative sacrifice times.
In vivo and in vitro degradation of glycine/DL‐lactic acid copolymers (1989)

A series of copolymers of glycine and DL-lactic acid with various compositions was synthesized and their in vivo and in vitro degradation behavior was studied. For the in vivo examination, discs of the copolymer films were subcutaneously implanted in rats. The in vitro studies were carried out in phosphate buffer at pH = 7.4 and 37 degrees C. The decrease in molecular weight, the loss of weight, and the tissue reactions of the different copolymers were determined after 2, 5, and 10 weeks. Poly(DL-lactic acid) was used as reference material. The in vivo and in vitro degradation behavior of the polymers was comparable. The decrease of molecular weight of the copolymers and poly(DL-lactic acid) in time was similar. The weight loss for copolymers with a higher mole fraction of glycine units started earlier. The copolymer with the highest content of glycine units disappeared completely within 10 weeks both in vivo and in vitro. The poly(DL-lactic acid) implant lost only 25% weight over the same period. Tissue reactions against all materials started with an acute inflammatory reaction caused by the trauma of implantation, followed by wound-healing processes, ending in a very mild foreign body reaction for the poly(DL-lactic acid) and a more excessive macrophage mediated foreign body reaction for the glycine/DL-lactic acid copolymers. The tissue reaction was more severe for polymers having a higher rate of degradation.
Bone marrow CX3CR1+ mononuclear cells relay a systemic microbiota signal to control hematopoietic progenitors in mice (2019)

The microbiota regulate hematopoiesis in the bone marrow (BM); however, the detailed mechanisms remain largely unknown. In this study, we explored how microbiota-derived molecules (MDMs) were transferred to the BM and sensed by the local immune cells to control hematopoiesis under steady-state conditions. We reveal that MDMs, including bacterial DNA (bDNA), reach the BM via systemic blood circulation and are captured by CX3CR1+ mononuclear cells (MNCs). CX3CR1+ MNCs sense MDMs via endolysosomal Toll-like receptors (TLRs) to produce inflammatory cytokines, which control the basal expansion of hematopoietic progenitors, but not hematopoietic stem cells, and their differentiation potential toward myeloid lineages. CX3CR1+ MNCs colocate with hematopoietic progenitors at the perivascular region, and the depletion of CX3CR1+ MNCs impedes bDNA influx into the BM. Moreover, the abrogation of TLR pathways in CX3CR1+ MNCs abolished the microbiota effect on hematopoiesis. These studies demonstrate that systemic MDMs control BM hematopoiesis by producing CX3CR1+ MNC-mediated cytokines in the steady-state.
Efficient coupling into slow-light one-dimensional fishbone waveguide by mode converter method (2017)

The high-order mode in a fishbone waveguide accommodates the easy manipulation of group index dispersion. To minimize Fresnel reflection, group velocity mismatch can be compensated for by a casual step taper, but with low coupling efficiency. Here, we propose a mode converter to boost the coupling efficiency to in and out of the slow-light fishbone waveguide. Split, phase, and side slots in a mode converter are employed to compensate for the mode mismatch in terms of the width of the lobes, the phase offset, and the power ratio between neighboring lobes. A high coupling efficiency of ∼70% leads to the efficient compact true-time delay required for phased array antennas.
Grafting reactions of vinyl acetate onto poly[(vinyl alcohol)-co-(vinyl acetate)] (1996)

The grafting preference of vinyl acetate onto the methine carbon of poly(vinyl alcohol) (PVOH) versus the acetate group of poly(vinyl acetate) (PVAc) was determined as part of an attempt to prepare novel branched PVOH from partially hydrolyzed PVAc. The results showed long chain grafting on the acetate groups of the PVAc units rather than the methine carbons of the PVOH or PVAc units. Decreasing the monomer or initiator concentration decreased the molecular weight of the graft copolymer formed. Of the initiators studied, ammonium persulfate gave the largest increase in copolymer molecular weight. Both hydrolysis and reacetylation combined with gel permeation chromatography (GPC) and 13C-NMR of the fully hydrolyzed material were used to estimate the number and location of grafts. © 1996 John Wiley & Sons, Inc.
Quality factor and phase noise improvements in MEMS resonators and oscillators (2017)

Quality factor and phase noise are important figures for any resonator or oscillator. This presentation focuses on studies to address improvements in quality factor in bulk mode resonators, and phase noise in nonlinear flexural mode resonators. In bulk resonators, anchor loss can be a significant limitation on quality factor, especially for resonators in the MHz range. This paper presents an informed study on anchor loss in bulk resonators, and demonstrates how proper anchor design can improve resonator performance. In flexural resonators, nonlinear effects have often been avoided due to amplitude dependence on frequency. However, it has been previously shown that nonlinear effects can improve phase noise performance of resonators. Here, we demonstrate a cascade of parametrically driven resonators that functions as a purely mechanical frequency divider, and also demonstrates improved phase noise performance over identical linear resonators.
Electronic spectra of metal-dioxygen complexes (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic spectra of metal-dioxygen complexesA. B. P. Lever and Harry B. GrayCite this: Acc. Chem. Res. 1978, 11, 9, 348–355Publication Date (Print):September 1, 1978Publication History Published online1 May 2002Published inissue 1 September 1978https://pubs.acs.org/doi/10.1021/ar50129a005https://doi.org/10.1021/ar50129a005research-articleACS PublicationsRequest reuse permissionsArticle Views690Altmetric-Citations139LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
475. Anionic Polyethyleneglycol Lipids Added to Cationic Lipoplexes Increase Their Plasmatic Circulation Time (2004)

Cationic liposomes have been widely sensed as good DNA compacting delivery agents. Although their use generally met with encouraging results in vitro, the results in vivo were rather disappointing, as they strongly interact with the blood components before they can reach the therapeutic target. Polyethyleneglycol (PEG) shielding has been proposed as a way to alleviate this effect, but was still found unsatisfactory in most instances for systemic administration. We demonstrate here that the insertion of anionic functions between the lipid part and the PEG, at a correct distance to favor electrostatic interactions with the outer cationic layer of the lipoplexes, provides not only a decrease in the mean peripheral charge of the lipoplex ( z potential), but also a greater colloidal stability of the particles in the presence of serum. Transfection in the lung is also decreased with negatively charged PEG shielding, although no significant changes are observed in the tumor. This encouraging new approach should consequently be combined with active extra-cellular receptor targeting to achieve the desired delivery of the therapeutic DNA to tumor tissues.
Radical Prostatectomy for Clinical Stage T1-2N0M0 Prostatic Adenocarcinoma: Long-Term Results (1990)

A total of 441 stage T1-2N0M0 and 11 stage T1-2N0M0 cancer patients with an elevated acid phosphatase level only, and 18 stage T1-2N+M0 cancer patients underwent radical prostatectomy. Analysis of the 441 stage T1-2N0M0 cancer patients demonstrated that failure and survival were a function of the disease being organ-confined, specimen-confined or margin-positive, with 10-year failure rates of 12, 30 and 60%, respectively. Of the patients with positive margins 44 were and 79 were not irradiated postoperatively. Postoperative radiation produced no survival advantage. No difference in interval to failure or of survival could be identified between 105 patients whose disease was diagnosed by transurethral resection and 328 who had a palpable abnormality. Eleven patients had negative bone and node findings but they had an elevated acid phosphatase level. All 8 patients not treated with immediate androgen deprivation failed within 36 months.
Should the Dentist Independently Assess and Treat Sleep-Disordered Breathing? (1998)

Sleep-disordered breathing is a chronic problem of the inappropriate mechanical collapse of the upper airway. Symptoms range from mild occasional snoring to severe obstructive sleep apnea. The standard of care for the diagnosis and treatment of sleep-disordered breathing by sleep medicine has been the use of the polysomnogram and continuous positive airway pressure. This approach is burdensome, costly, and ineffective due to lack of compliance with or rejection of treatment. Oral appliances are highly effective in managing the mild snorer to the moderate sleep apneic and are approaching the efficacy of continuous positive airway pressure with the severe apneic. The dentist can and should manage these patients. However, the dental practitioner must acquire sufficient training and knowledge to appropriately treat these patients.
AlN Passivation Over AlGaN/GaN HFETs for Surface Heat Spreading (2010)

Reduction of thermal resistance in AlGaN/GaN heterojunction field-effect transistors (HFETs) is critical for further increase in their output power to be handled in these promising material systems. In this paper, we present a new technique to reduce it using polycrystalline AlN passivation deposited by dc sputtering as a surface heat spreader over AlGaN/GaN HFETs. The AlN is deposited by dc sputtering, and it is well oriented to the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</i> -axis. The measured thermal resistances of AlGaN/GaN HFETs with AlN passivation are lower than those with SiN passivation, which well agree with the results of the thermal simulation. The most notable change of the characteristics by AlN passivation is that the drain current increases by 30%, and the on-state resistance is reduced by 66% by the passivation; moreover, the current collapse suppresses successfully. As a result, the radio frequency output power is higher than that with conventional SiN passivation and is increased by increasing the thickness of AlN passivation. Thus, reduction of the thermal resistance and higher output power by AlN passivation is experimentally achieved.
A Look at the Mobile App Identification Landscape (2018)

The number of mobile devices and apps have grown tremendously in recent years, resulting in a dramatic increase in mobile traffic. This trend is expected to create a nearly 10-fold increase in global mobile data over the next 5 years, bringing mobile traffic analysis into focus. However, traditional traffic analysis approaches don't work well for mobile traffic. Mobile apps possess unique characteristics that make it exceedingly difficult to determine which app generated a flow. Here, the author discusses the challenges in mobile traffic analysis and presents a survey of techniques that address these issues.
Cell injury unmasks a latent proangiogenic phenotype in mice with increased expression of FGF2 in the retina (2000)

Fibroblast growth factor-2 (FGF2) is a potent mitogen for vascular endothelial cells and exogenous administration of FGF2 stimulates angiogenesis. However, increased expression of FGF2 in the retina does not cause angiogenesis. One possible explanation is that FGF2 may not be capable of initiating angiogenesis unless it is administered in pharmacologic levels or there is coexpression of another angiogenic factor. Alternatively, there may be control mechanisms that sequester FGF2 in vivo, preventing it from manifesting its in vitro angiogenic activity. We tested the first hypothesis by crossing mice that express FGF2 in the retina with mice that express vascular endothelial growth factor (VEGF) in the retina. Surprisingly, despite comparable levels of VEGF expression, mice that expressed both FGF2 and VEGF had significantly less neovascularization than mice that expressed VEGF alone. The second hypothesis was tested by treating Rho/FGF2 transgenic mice with low-intensity laser photocoagulation that disrupts photoreceptors, but does not rupture Bruch's membrane, or intense laser that ruptures Bruch's membrane. In Rho/FGF2 transgenics, but not wild type mice, choroidal neovascularization developed in areas of low-intensity laser. Both wild type and transgenic mice developed choroidal neovascularization in areas of intense laser that ruptured Bruch's membrane, but the area of neovascularization was significantly greater in transgenics. These data suggest that increased retinal expression of FGF2 is angiogenic only when it is accompanied by cell injury that overcomes sequestration control mechanisms.
Safety and immunogenicity of a novel 10-valent pneumococcal conjugate vaccine candidate in adults, toddlers, and infants in The Gambia—Results of a phase 1/2 randomized, double-blinded, controlled trial (2019)

SIIPL-PCV was well-tolerated, had an acceptable safety profile, and was immunogenic for all vaccine serotypes. Results support the evaluation of SIIPL-PCV in a phase 3 non-inferiority trial. Clinicaltrials.gov: NCT02308540.
High-fidelity color video reproduction of open surgery by six-band camera (2010)

The video capture of surgery is becoming widely used but the colors reproduced by conventional RGB-based video
systems differ from the original. In this work, 6-band multispectral video was applied to the open surgery for highfidelity
color reproduction, and medical doctors visually evaluated the reproduced image quality. As a result, 1) the 6-
band video system was rated significantly higher in reproducibility, fidelity, and material appearance. 2) The
perceived color differences between 6-band/RGB and 6-band/3-band were significant. 3) Color videos from 6-band data
were transmitted via network, and approximately enough quality was obtained with 15Mbps bit rate. These results show
the potential of multispectral technology for the improvement of surgical video quality.
The role of sulfur alloying in defects and transitions in copper indium gallium diselenide disulfide thin films (2007)

xv, 132 p. : ill. A print copy of this title is available from the UO Libraries, under the call number: SCIENCE TK7871.15.F5 H325 2007
Percarbonate oxidation of landfill leachates towards removal of ultraviolet quenchers (2017)

Sodium percarbonate can effectively reduce UV absorbance and UV quenchers in landfill leachates with potentially low cost per organic removal.
Immobilization of a carbon nanomaterial-based localized drug-release system using a bispecific material-binding peptide (2018)

This oxSWNHs-immobilized system can be used to modify the surface of Ti in implants and be loaded with drugs that stimulate osteogenesis and bone regeneration.