gebhart/patrepeval huggingface dataset:
Structural Integrity of the Golgi is Temperature Sensitive in Conditional‐Lethal Mutants with No Detectable GM130 (2003)

At 39.5 degrees C in the temperature-sensitive, conditional-lethal mutant ldlG, glycoprotein processing is disrupted and secretion is blocked. The ultrastructure of the Golgi apparatus in ldlG cells was examined using immunofluorescence and immunoelectron microscopy. At 34 degrees C the structure of the Golgi apparatus was normal, whereas after incubation at 39.5 degrees C for 12 h it disassembled into dispersed vesicles. These reassembled into stacks when cells were returned to 34 degrees C for 6 h. At both 34 and 39.5 degrees C, all Golgi markers examined were present at wild-type levels except GM130, which was undetectable (<5% of control). Transfection with GM130 corrected the mutant phenotypes. Although the endogenous gene encoding NSF is apparently normal in ldlG cells, all mutant phenotypes were corrected by transfection with NSF, suggesting that NSF functioned as an extragenic suppressor. These findings provide additional support for a role of GM130 in determining the properties of the Golgi apparatus and for NSF in influencing GM130 stability and function. They also suggest that, at 34 degrees C, detectable levels of GM130 are not required for normal Golgi morphology and function, but that GM130 - or a GM130-dependent protein(s) - does play a role in protecting the Golgi, and thus the cells, from stress at higher temperatures.
Contribution of Intramuscular Connective Tissue to the Viscoelastic Properties of Post‐Rigor Bovine Muscle (1988)

ABSTRACT An indepth biomechanical study was performed to characterize more fully the viscoelastic behavior of post‐rigor bovine muscle, using samples oriented parallel and perpendicular to the muscle fiber direction. Two enzymes were used to degrade the intramuscular connective tissue (IMCT) to evaluate its mechanical contribution. An unusual stress‐strain curve was found in the parallel oriented samples, with enzymolysis affecting the curve at strains larger than 8%. Reductions in stresses in both orientations due to enzymolysis were 50% with extensibility unchanged. Stress relaxation tests indicated that regardless of orientation or treatment the relative stress‐relaxation was unchanged. IMCT contributed substantially to the mechanical response only at large deformations.
Effects of magnesium ion on kinetic stability and spin distribution of phenoxyl radical derived from a vitamin E analogue: mechanistic insight into antioxidative hydrogen-transfer reaction of vitamin EElectronic supplementary information available: calculated spin density distributions and dependence of kHT on [Mg2+] for hydrogen transfer. See http://www.rsc.org/suppdata/p2/b2/b205380b/ (2002)

The phenoxyl radical 1˙ of a vitamin E analogue, generated by the reaction of 2,2,5,7,8-pentamethylchroman-6-ol (1H) with 2,2-di(4-tert-octylphenyl)-1-picrylhydrazyl (DPPH˙) or galvinoxyl (G˙), was significantly stabilized by the presence of Mg2+. Addition of Mg2+ into a solution of 1˙ resulted in a red shift of the absorption band of 1˙ as well as a decrease in the g value of the EPR spectrum of 1˙, indicating a complex formation between 1˙ and Mg2+. The complexation between the phenoxyl radical and Mg2+ significantly retards the disproportionation reaction of 1˙ by electronic repulsion between the metal cation and a generated organic cation (1+), leading to stabilization of the organic radical species. No effect of Mg2+ on the rate of hydrogen atom transfer from 1H to DPPH˙ or to G˙ was observed, suggesting that the hydrogen-transfer reaction between 1H and DPPH˙ or G˙ proceeds via a one-step hydrogen atom transfer mechanism rather than electron-transfer followed by proton transfer.
Cerium-Doped Copper(II) Oxide Hollow Nanostructures as Efficient and Tunable Sensors for Volatile Organic Compounds (2018)

Tuning sensing capabilities of simple to complex oxides for achieving enhanced sensitivity and selectivity toward the detection of toxic volatile organic compounds (VOCs) is extremely important and remains a challenge. In the present work, we report the synthesis of pristine and Ce-doped CuO hollow nanostructures, which have much higher VOC sensing and response characteristics than their solid analogues. Undoped CuO hollow nanostructures exhibit high response for sensing of acetone as compared to commercial CuO nanoparticles. As a result of doping with cerium, the material starts showing selectivity. CuO hollow structures doped with 5 at. % of Ce return highest response toward methanol sensing, whereas increasing the Ce doping concentration to 10%, the material shows high response for both-acetone and methanol. The observed tunability in selectivity is directly linked to the varying concentration of the oxygen defects on the surface of the nanostructures. The work also shows that the use of hollow nanostructures could be the way forward for obtaining high-performance sensors even by using conventional and simple metal or semiconductor oxides.
pH Stability and Electrocatalytic Oxygen Evolution Activity of Ferrate (2013)

Abstract not Available.
Effect of para substituent on rates of phenyl ring rotation in gallium complexes of para-substituted tetraphenylporphyrins (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of para substituent on rates of phenyl ring rotation in gallium complexes of para-substituted tetraphenylporphyrinsS. S. Eaton, D. M. Fishwild, and G. R. EatonCite this: Inorg. Chem. 1978, 17, 6, 1542–1545Publication Date (Print):June 1, 1978Publication History Published online1 May 2002Published inissue 1 June 1978https://pubs.acs.org/doi/10.1021/ic50184a031https://doi.org/10.1021/ic50184a031research-articleACS PublicationsRequest reuse permissionsArticle Views146Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nonlinear model reduction strategies for rapid thermal processing systems (1998)

We present a systematic method for developing low order nonlinear models from physically based, large scale finite element models of rapid thermal processing (RTP) systems. These low order models are extracted from transient results of a detailed finite element model using the proper orthogonal decomposition (POD) method. Eigenfunctions obtained from the POD method are then used as basis functions in spectral Galerkin expansions of the governing partial differential equations solved by the finite element model to generate the reduced models. Simulation results with the reduced order models demonstrate good agreement with steady state and transient data generated from the finite element model, with an order of magnitude reduction in execution time.
Cdc1 and the Vacuole Coordinately Regulate Mn2+ Homeostasis in the Yeast Saccharomyces cerevisiae (1998)

The yeast CDC1 gene encodes an essential protein that has been implicated in the regulation of cytosolic [Mn2+]. To identify factors that impinge upon Cdc1 or the Cdc1-dependent process, we isolated second-site suppressors of the conditional cdc1-1(Ts) growth defect. Recessive suppressors define 15 COS (CdcOne Suppressor) genes. Seven of the fifteen COS genes are required for biogenesis of the vacuole, an organelle known to sequester intracellular Mn2+. An eighth gene, COS16, encodes a vacuolar membrane protein that seems to be involved in Mn2+ homeostasis. These results suggest mutations that block vacuolar Mn2+ sequestration compensate for defects in Cdc1 function. Interestingly, Cdc1 is dispensable in a cos16delta deletion strain, and a cdc1delta cos16delta double mutant exhibits robust growth on medium supplemented with Mn2+. Thus, the single, essential function of Cdc1 is to regulate intracellular, probably cytosolic, Mn2+.
A novel highly thermal reliable halogen-free system for copper clad laminates (2010)

The developing trend for the high performance electronic devices still focuses on light, thin, short and small exhibiting high heat resistance and multi-functional properties, To meet the above requirements, the copper clad laminate substrate preferably produced from the materials having high thermal resistance, high glass transition temperature and low CTE. For the above purposes, we developed a new halogen-free composition which comprises nitrogen-containing resin, hardener, inorganic filler and phosphorous — containing flame retardant, when the new resin composition is cured, it will import the CCL with excellent physical properties.
Error measure comparison of currently employed dose-modulation schemes for e-beam proximity effect control (1995)

Standard matrix inversion methods of e-beam proximity correction are compared with a variety of pseudoinverse approaches based on gradient descent. It is shown that the gradient descent methods can be modified using 'regularizers' (terms added to the cost function minimized during gradient descent). This modification solves the 'negative dose' problem in a mathematically sound way. Different techniques are contrasted using a weighted error measure approach. It is shown that the regularization approach leads to the highest quality images. In some cases, ignoring negative doses yields results which are worse than employing an uncorrected dose file.
Ab initio quantum mechanics‐based free energy perturbation method for calculating relative solvation free energies (2006)

A free energy perturbation (FEP) method was developed that uses ab initio quantum mechanics (QM) for treating the solute molecules and molecular mechanics (MM) for treating the surroundings. Like our earlier results using AM1 semi empirical QMs, the ab initio QM/MM-based FEP method was shown to accurately calculate relative solvation free energies for a diverse set of small molecules that differ significantly in structure, aromaticity, hydrogen bonding potential, and electron density. Accuracy was similar to or better than conventional FEP methods. The QM/MM-based methods eliminate the need for time-consuming development of MM force field parameters, which are frequently required for drug-like molecules containing structural motifs not adequately described by MM. Future automation of the method and parallelization of the code for Linux 128/256/512 clusters is expected to enhance the speed and increase its use for drug design and lead optimization.
Surgical technique for long-term cecal cannulation in the Yucatan minipig (Sus scrofa domestica). (2006)

Measurements of standardized ileal digestibility yield more useful results than do those of fecal digestibility. To that end, cecal cannulation of the pig has been performed extensively in an attempt to model the digestive processes of humans. Here we introduce a technique for the placement of a permanent cecal cannula with a silicon port that is larger in diameter than those previously described in the literature. A large lumen offers several advantages, most notably ease in collection of larger samples and introduction of materials into the cecum. To date, this technique has been used successfully to cannulate 39 Yucatan minipigs at our institution. Long-term, there have been no major complications with the procedure or cannulas.
ChemInform Abstract: Increase of the Anti‐HIV Activity of D4T in Human T‐Cell Culture by the Use of the Sate Pronucleotide Approach (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Introduction to Chemosensors (2002)

This chapter contains sections titled: Introduction Survey and Classification of Chemosensors Chemoresistors MOS Organic CPs Chemocapacitors (CAP) Potentiometric Odor Sensors MOSFET Gravimetric Odor Sensors QCM SAW Optical Odor Sensors SPR Fluorescent Odor Sensors Other Optical Approaches Thermal (Calorimetric) Sensors Amperometric Sensors Summary of Chemical Sensors
PMM.44 Implementation of an “at risk” triage service for perinatal mental health in a tertiary hospital in Bristol (2014)

Background The NICE 2007 guidelines for antenatal and postnatal mental health suggested that women are screened by midwives at booking to identify a past history or ongoing history of perinatal mental ill-health. 1 We hypothesised that the main barrier to accurate identification was a lack of confidence in the clinical pathway, as opposed to lack of skill in asking the questions. 2,3 We introduced a simplified and formalised triage system at St. Michael’s Hospital, Bristol, in 2012. Method An “at risk” fax notification form was completed by midwives for those women who screened positive using the ‘Whooley’ questions. This information was triaged and streamlined patients to either an antenatal appointment or to the appropriate support services. Referral data were analysed from January 2012 to July 2013. Results The most common conditions referred included depression (55%), anxiety (19%), eating disorders (6%) and bipolar disorder (5%). 68% were referred onto a consultant-led antenatal clinic, 26% were for information only and a letter sent to the midwife to refer back if necessary and 5% were referred to the New Horizon Mother and Baby Centre. During the period January 2013 to July 2013 there were a total of 158 referrals using the ‘at risk’ notification form compared with 53 referrals in the previous 6 months. The number of words per referral increased significantly demonstrating an increase in the detail recorded. Conclusion We concluded that when midwives have confidence in the referral pathway they were more empowered to identify women at risk of perinatal mental ill-health. References Antenatal and Postnatal Mental Health. The NICE guideline on clinical management and service guidance. The British Psychological Society and Royal College of Psychiatrists, 2007 Ross-Davie M, Elliott S, Sarkar A, Green L. A public health role in perinatal mental health. Are Midwives ready? British Journal of Midwifery , 2006 Jun;14(6):330–334 McCauley K, Elsom S, Muir-Cochrane E, Lynehm J. Midwives and assessment of perinatal mental health. J Pschiatr Mental Health Nurs . 2011 Nov;18(9):786–95
Down‐regulation of type I interferon receptor sensitizes bladder cancer cells to vesicular stomatitis virus‐induced cell death (2009)

The intrinsic oncolytic specificity of vesicular stomatitis virus (VSV) is currently being exploited to develop alternative therapeutic strategies for bladder cancer and other cancers. Previously we reported that oncolytic VSV is a potent agent for intravesical treatment of high risk bladder cancer. We observed that VSV preferentially targeted bladder cancer cells resistant to type I interferon (IFN) treatment. The goal of the current study was to further elucidate the nature of the molecular defect of IFN signaling by which bladder cancer cells become susceptible to VSV infection. Using a tissue microarray composed of human bladder cancer cores, we observed that expression of type I IFN receptor (IFNAR) was decreased relative to normal bladder tissue. Advanced bladder cancers had even lower expression of IFNAR. We found that bladder cancer cells susceptible to VSV-induced lysis had low expression of IFNAR as well. We hypothesized that down-regulation of IFNAR in bladder cancer cells may be a molecular mechanism responsible for resistance to type I IFN treatment and sensitivity to VSV oncolysis. SiRNA knockdown of IFNAR indeed facilitated replication of VSV in cells previously resistant to VSV treatment. Blocking IFNAR with a neutralizing antibody showed a similar effect. Hence down-regulation of IFNAR in bladder cancer may be one of the primary molecular mechanisms for clinical IFN resistance. However, this also facilitates VSV replication and oncolysis in high risk bladder cancers and provides a basis for selecting bladder cancer patients for IFN or oncolytic VSV therapy in future clinical trials.
Comparisons of Measured Rate Constants with Spectroscopically Determined Electron-Transfer Parameters (2007)

This work involves comparison of rate constants measured for an intervalence (IV) compound with electron-transfer parameters derived from its optical absorption spectrum. The temperature-dependent rate constants for the radical cation having 3-tert-butyl-2,3-diazabicyclo[2.2.2]oct-2-yl (hydrazine) charge-bearing units attached para to a tetramethylbenzene bridge (1+) were previously measured. In this study, resonance Raman is used to calculate the magnitudes of the distortions of normal modes of vibration caused by excitation into the intervalence absorption band. These data produce a vibrational reorganization energy lambdavsym of 9250 cm(-1), and averaged single-mode omegav for use in the Golden Rule equation of 697 cm(-1). Zhu-Nakamura theory has been used to calculate preexponential factors for analysis of the previously measured variable temperature optical spectra using quartic-enhanced intervalence bands to extract the total reorganization energy and the intramolecular electron-transfer rate constants for intramolecular electron transfer using electron spin resonance. In contrast to using the Golden Rule equation, separation of lambda into solvent and vibrational components is not significant for these data. The Zhu-Nakamura theory calculations produce ln(k/T) versus 1/T slopes that are consistent with the experimental data for electronic couplings that are somewhat larger than the values obtained from the optical spectra using Hush's method.
TiO2/HfO2 Bi-Layer Gate Stacks Grown by Atomic Layer Deposition for Germanium-Based Metal-Oxide-Semiconductor Devices Using GeOxNy Passivation Layer (2011)

Material and electrical properties of TiO 2 /HfO 2 bi-layer gate stacks were investigated for germanium (Ge) based metal-oxidesemiconductor devices. In situ NH 3 plasma treatment was employed to passivate the Ge surface and promising performance including low capacitance-voltage hysteresis and interface trap density was achieved. It shows a superior dielectric breakdown voltage (4.2-3.4 V) for the TiO 2 /HfO 2 bi-layer stacks than HfO 2 single layer stack at a similar capacitance equivalent thickness (CET) of 1.6 nm. A minimum CET of 1.4 nm was obtained for capacitors on both p and n-type Ge (100) with a gate leakage current density < 4 10 7 A/cm 2 at V FB 6 1 V.
The Quorum-Sensing Molecule Autoinducer 2 Regulates Motility and Flagellar Morphogenesis in Helicobacter pylori (2007)

The genome of the gastric pathogen Helicobacter pylori contains a homologue of the gene luxS, which has been shown to be responsible for production of the quorum-sensing signal autoinducer 2 (AI-2). We report here that deletion of the luxS gene in strain G27 resulted in decreased motility on soft agar plates, a defect that was complemented by a wild-type copy of the luxS gene and by the addition of cell-free supernatant containing AI-2. The flagella of the luxS mutant appeared normal; however, in genetic backgrounds lacking any of three flagellar regulators--the two-component sensor kinase flgS, the sigma factor sigma28 (also called fliA), and the anti-sigma factor flgM--loss of luxS altered flagellar morphology. In all cases, the double mutant phenotypes were restored to the luxS+ phenotype by the addition of synthetic 4,5-dihydroxy-2,3-pentanedione (DPD), which cyclizes to form AI-2. Furthermore, in all mutant backgrounds loss of luxS caused a decrease in transcript levels of the flagellar regulator flhA. Addition of DPD to luxS cells induced flhA transcription in a dose-dependent manner. Deletion of flhA in a wild-type or luxS mutant background resulted in identical loss of motility, flagella, and flagellar gene expression. These data demonstrate that AI-2 functions as a secreted signaling molecule upstream of FlhA and plays a critical role in global regulation of flagellar gene transcription in H. pylori.
Branching Fraction Measurements of the Rare $B^0_s\rightarrow\phi\mu^+\mu^-$ and $B^0_s\rightarrow f_2^\prime(1525)\mu^+\mu^-$ Decays (2021)

The branching fraction of the rare $B^0_s\rightarrow\phi\mu^+\mu^-$ decay is measured using data collected by the LHCb experiment at center-of-mass energies of 7, 8, and 13 TeV, corresponding to integrated luminosities of 1, 2, and 6 fb$^{-1}$, respectively. The branching fraction is reported in intervals of q$^2$, the square of the dimuon invariant mass. In the q$^2$ region between 1.1 and 6.0 GeV$^2$/c$^4$, the measurement is found to lie 3.6 standard deviations below a standard model prediction based on a combination of light cone sum rule and lattice QCD calculations. In addition, the first observation of the rare $B^0_s\rightarrow f_2^\prime(1525)\mu^+\mu^-$ decay is reported with a statistical significance of 9 standard deviations and its branching fraction is determined.
Enhanced Emission in Composite Multilayers of Amorphous TiO2-Gel and Eu3+ Ions (2002)

Abstract Ultrathin films of (TiO2/Eu3+)n and (TiO2/PAA/Eu3+)n composites were prepared by the surface sol-gel process and the subsequent chemisorption/coordination of Eu3+ ions. Amorphous TiO2-gel layers were found to act as sensitizer for efficient emission of Eu3+.
Longitudinal Distribution of Ozone Absorption in the Lung: Effect of Continuous Inhalation Exposure (1996)

The effect of continuous exposure to ozone on the absorption of ozone in the conducting airways of human lungs was investigated with a bolus-response method. Eleven healthy nonsmoking college students (8 males, 3 females) were exposed at rest for 2 h on 3 separate days to air containing 0 ppm, 0.12 ppm, and 0.36 ppm ozone. A personal inhalation chamber equipped with a head-only clear plastic dome was used for exposure. Every 30 min a subject removed the dome and orally inhaled a series of five ozone-air boluses, each in a separate breath. Penetration of the boluses distal to the lips was targeted in the range of 70-120 ml (corresponding to the central conducting airways). By integrating the inhaled and exhaled-ozone concentration curves, we obtained the absorbed fraction (lambda) and the dispersion (sigma2) of the ozone bolus for each test breath. In addition, the subtraction of baseline measurements made just before exposure enabled us to determine the changes in absorbed fraction (deltalambda) and in dispersion (deltasigma2) that resulted from exposure alone. Absorbed fraction decreased, but sigma2 increased during O3 exposure, and the differences in deltalambda and in deltasigma2 between breathing air and exposure to either 0.12 ppm or 0.36 ppm O3 were significant. We concluded that exposure of the conducting airways to O3 reduced their capacity to absorb O3, possibly by the depletion of biochemical substrates that are normally oxidized by O3.