gebhart/patrepeval huggingface dataset:
Suppression and induction of epileptic activity by neuronal grafts. (1988)

Fetal rat brain cell suspensions prepared from either the locus coeruleus region or hippocampus were implanted bilaterally into the subcortically denervated seizure-prone hippocampus of adult rats. Animals with locus coeruleus grafts were protected against picrotoxin-induced behavioral seizures and had significantly fewer interictal spikes. In contrast, in rats with fetal hippocampal grafts the incidence of interictal spikes was significantly higher than in lesion-only controls, and spontaneous behavioral seizures occurred in almost half of the animals. We suggest that neuronal grafting offers an alternative method for studying the mechanisms and control of epileptic brain activity.
SupervisorBot: NLP-Annotated Real-Time Recommendations of Psychotherapy Treatment Strategies with Deep Reinforcement Learning (2023)

We present a novel recommendation system designed to provide real-time treatment strategies to therapists during psychotherapy sessions. Our system utilizes a turn-level rating mechanism that forecasts the therapeutic outcome by calculating a similarity score between the profound representation of a scoring inventory and the patient's current spoken sentence. By transcribing and segmenting the continuous audio stream into patient and therapist turns, our system conducts immediate evaluation of their therapeutic working alliance. The resulting dialogue pairs, along with their computed working alliance ratings, are then utilized in a deep reinforcement learning recommendation system. In this system, the sessions are treated as users, while the topics are treated as items. To showcase the system's effectiveness, we not only evaluate its performance using an existing dataset of psychotherapy sessions but also demonstrate its practicality through a web app. Through this demo, we aim to provide a tangible and engaging experience of our recommendation system in action.
GNN4TJ: Graph Neural Networks for Hardware Trojan Detection at Register Transfer Level (2021)

The time to market pressure and resource constraints has pushed System-on-Chip (SoC) designers toward outsourcing the design and using third-party Intellectual Property (IP). It has created an opportunity for rogue entities in the Integrated Circuit (IC) supply chain to insert malicious circuits in the hardware design, known as Hardware Trojans (HT). HT detection is a major hardware security challenge, and its early discovery is crucial because postponing the removal of HT to late in design or after the fabrication process would be very expensive. Current works suffer from several shortcomings such as reliance on a golden HT-free reference, unable to identify all types of HTs or unknown ones, burdening the designer with the manual review of code, or scalability issues. To overcome these limitations, we propose GNN4TJ, a novel golden reference-free HT detection method in the register transfer level (RTL) based on Graph Neural Network (GNN). GNN4TJ represents the hardware design as its intrinsic data structure, a graph, and generates the data flow graphs for RTL codes. We utilize GNN to extract the features from DFG, learn the circuit's behavior, and identify the presence of HT, in a fully automated pipeline. We evaluate our model on a dataset that we create by expanding the Trusthub [1] HT benchmarks. The results demonstrate that GNN4TJ detects unknown HT with 97% recall (true positive rate) very fast in 21.1ms.
Natural history of multiple myeloma with de novo del(17p) (2019)

We compared the outcomes of 310 patients with newly diagnosed multiple myeloma with del(17p) detected by FISH to patients with high-risk translocations (HRT) (n = 79) and standard-risk (SR) cytogenetics (n = 541). The median progression-free survival (PFS) following initial therapy for the three groups was 21.1, 22, and 30.1 months, respectively (P = 0.437- del(17p) vs. HRT); the median overall survival (OS) was 47.3, 79.1, and 109.8 months, respectively, (P = 0.007- del(17p) vs. HRT). PFS and OS for patients with relative loss of 17p (n = 21) were comparable to other patients with del(17p). The PFS was similar between the del(17p) and HRT groups when stratified for age, ISS stage or treatment. The OS of del(17p) and HRT groups were similar in presence of advanced age, ISS III stage or if patients did not receive a proteasome-inhibitor containing induction. ISS III stage, high LDH and HRT, but not the percentage of cells with del(17p) predicted shorter OS in patients with del(17p). The median OS for low (ISS I, normal LDH and no HRT), intermediate (neither low nor high-risk) and high-risk (ISS III and either elevated LDH or coexistent HRT) groups among del(17p) patients were 96.2, 45.4, and 22.8 months, respectively, allowing further risk stratification.
Potassium channel openers are uncoupling protonophores: implication in cardioprotection (2004)

Excessive build-up of mitochondrial protonic potential is harmful to cellular homeostasis, and modulation of inner membrane permeability a proposed countermeasure. Here, we demonstrate that structurally distinct potassium channel openers, diazoxide and pinacidil, facilitated transmembrane proton translocation generating H(+)-selective current through planar phospholipid membrane. Both openers depolarized mitochondria, activated state 4 respiration and reduced oxidative phosphorylation, recapitulating the signature of mitochondrial uncoupling. This effect was maintained in K(+)-free conditions and shared with the prototypic protonophore 2,4-dinitrophenol. Diazoxide, pinacidil and 2,4-dinitrophenol, but not 2,4-dinitrotoluene lacking protonophoric properties, preserved functional recovery of ischemic heart. The identified protonophoric property of potassium channel openers, thus, implicates a previously unrecognized component in their mechanism of cardioprotection.
Suppressed Nonradiative Decay of an Exciplex by an Inert Host for Efficiency Improvement in a Green Fluorescence Organic Light-Emitting Diode (2019)

High efficiency green fluorescent organic light-emitting diodes (OLEDs) were developed by employing a ternary sensitizing host based on exciplexes which suppressed nonradiative exciton decay of exciplexes. The sensitizing host comprised a mixture of conventional exciplexes and an extra host, which controlled the nonradiative exciton decay because of reduction of intermolecular interaction between exciplexes by the extra host. In the thermally activated delayed fluorescent type exciplex host of tris(4-carbazol-9-ylphenyl)amine (TCTA) and (3′-(4,6-diphenyl-1,3,5-triazin-2-yl)-(1,1′-biphenyl)-3-yl)-9-carbazole (CzTrz), (oxybis(2,1-phenylene))bis(diphenylphosphine oxide) (DPEPO) was added as the extra host to increase the distance between p-type and n-type hosts comprising the exciplex host and between exciplexes. The addition of DPEPO in the TCTA/CzTrz exciplex increased the photoluminescence quantum yield of the nondoped exciplex from 61.1 to 65.8% and the green fluorophore-doped exciplex from 60.1 to 69.2%. Because of the reduced nonradiative exciton loss by DPEPO, the maximum external quantum efficiency of the green fluorescent OLEDs was improved from 11.2 to 13.6% at a DPEPO content of 50%.
Altered CD8+ T-Cell Responses When Immunizing With Multiepitope Peptide Vaccines (2006)

Efforts to develop effective cancer vaccines often use combinations of immunogenic peptides to increase the applicability and effectiveness of the immunizations. The immunologic consequences of combining more than 1 self/tumor antigen in a single vaccine emulsion remain unclear, however. We performed 2 sequential clinical trials in patients at high risk for melanoma recurrence. Patients were given the highly immunogenic gp100:209-217(210M) peptide and the less immunogenic tyrosinase:368-376(370D) peptide once every 3 weeks for 4 weeks. This vaccination course was 12 weeks long, and patients were vaccinated for up to 4 courses (16 total vaccinations). In the first trial in 31 patients, the peptides were emulsified separately in incomplete Freund adjuvant and injected at 2 different sites. In the second trial in 33 patients, the peptides were emulsified together and injected at the same site. Cryopreserved lymphocytes were obtained by apheresis after each course and were evaluated for antipeptide activity using tetramer, enzyme-linked immunospot, and in vitro sensitization boost assays. When the peptides were injected at separate sites, robust specific reactivity to the native gp100:209-217 peptide was measured by each of the assays, whereas immunization with the tyrosinase:368-376(370D) peptide was far less effective. When the peptides were emulsified and injected together at the same site, immunization to the gp100:209-217(210M) epitope dropped precipitously, whereas reactivity to the tyrosinase:368-376(370D) peptide was enhanced. These cautionary data indicate that mixing peptides in the same emulsion can alter reactivity compared with peptides injected separately by mechanisms that may include the induction of localized nonspecific inflammation or competitive binding of peptides to major histocompatibility complex molecules.
PU.1 controls fibroblast polarization and tissue fibrosis (2019)

Abstract Fibroblasts are polymorphic cells with pleiotropic roles in organ morphogenesis, tissue homeostasis and immune responses. In fibrotic diseases, fibroblasts synthesize abundant amounts of extracellular matrix, which induces scarring and organ failure. By contrast, a hallmark feature of fibroblasts in arthritis is degradation of the extracellular matrix because of the release of metalloproteinases and degrading enzymes, and subsequent tissue destruction. The mechanisms that drive these functionally opposing pro-fibrotic and pro-inflammatory phenotypes of fibroblasts remain unknown. Here we identify the transcription factor PU.1 as an essential regulator of the pro-fibrotic gene expression program. The interplay between transcriptional and post-transcriptional mechanisms that normally control the expression of PU.1 expression is perturbed in various fibrotic diseases, resulting in the upregulation of PU.1, induction of fibrosis-associated gene sets and a phenotypic switch in extracellular matrix-producing pro-fibrotic fibroblasts. By contrast, pharmacological and genetic inactivation of PU.1 disrupts the fibrotic network and enables reprogramming of fibrotic fibroblasts into resting fibroblasts, leading to regression of fibrosis in several organs.
A Cochlear Implant System with Infra-red Telemetry for Behaving Animals (2005)

A new cochlear implant system for animal experiments is proposed. The system uses a DSP-based sound processor to implement the six-channel continuous interleaved sampling (CIS) speech processing strategy. An infra-red telemetry is designed to remotely connect the power-demanding sound processor to receiver/stimulator attached on the animal. This enables the animal to move freely. The receiver/stimulator consumes about 40mW, thus can operates for about 200hours without changing battery.
Demonstration of the 1.53-µm coherent DIAL for simultaneous profiling of water vapor density and wind speed (2020)

The 1.53-µm coherent differential absorption lidar (DIAL) is demonstrated for the simultaneous profiling of water vapor (H<sub>2</sub>O) density and wind speed. The optical setup is fiber-based. The wavelength locking circuit can achieve precise locking of 13.0 MHz by the combination of the line center locking to the hydrogen cyanide (HCN) absorption line and offset locking to the H<sub>2</sub>O absorption wavelength. The measurable range for the simultaneous profiling is up to 1.2 km. The DIAL-measured H<sub>2</sub>O density is compared with the one measured by an in-situ sensor. Qualitative good agreement is shown with the random error of 0.56 g/m<sup>3</sup>.
A generalized family of parameter estimation techniques (2009)

The extended Baum-Welch (EBW) transformations is one of a variety of techniques to estimate parameters of Gaussian mixture models. In this paper, we provide a theoretical framework for general parameter estimation and show the relationship between these different techniques. We introduce a general family of model parameter updates that generalizes a Baum-Welch (BW) recursive process to an arbitrary objective function of Gaussian Mixture Models, and show how other common parameter estimation techniques belong to this family of model update rules. Furthermore, we formulate the construction of an even more general family of update rules that has any specified value as a gradient steepness which belongs to the family of EBW gradient steepness, measuring how much an initial model is moved to an estimated updated model.
Topical Dexamethasone and Tympanic Membrane Perforation Healing in Otitis Media (2010)

Topical dexamethasone hinders TM healing in a chinchilla model of AOM at short-term follow-up. Longer follow-up is needed.
Supplementary Table 5 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner (2023)

&lt;p&gt;PDF file - 69K, H1395 cells were transfected with firefly luciferase siRNA, cIAP1 siRNA, cIAP2 siRNA, XIAP siRNA, caspase 3 siRNA, caspase 4 siRNA, caspase 9 siRNA, caspase 8 siRNA, RIPK1 siRNA, TNFR1 siRNA, or cIAP1, cIAP2, and XIAP siRNAs, or treated with JP1201. 24 hours later, cells were harvested and total RNA prepared (RNeasy Plus Mini Kit, 74134, Qiagen, Hilden, Germany). cDNA was synthesized from 1 mg total RNA using the iScript cDNA synthesis kit (BioRad, Hercules, CA). Gene specific TaqMan probes (Applied Biosystems, Foster City, CA) were used to quantitate GAPDH, cIAP1, cIAP2, XIAP, Caspase 3, 4, 8, and 9, RIPK1, TNFR1, and TNFa levels in biological duplicates as well as duplicate samples of siRNA transfected H1395 cells. The 2-DDCT method was used to calculate relative expression levels (19). Expression of target genes were normalized to GAPDH expression, and expression was normalized to H1395 cells transfected with luciferase siRNA. * - indicates where no gene expression data has been determined. ** ND indicates where gene expression was not detected.&lt;/p&gt;
The impact of SMARTpass algorithm status on inappropriate shock rates in the UNTOUCHED Study (2022)

Abstract Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): Boston Scientific Corporation Background The current Subcutaneous ICD (S-ICD) model incorporates SMART Pass (SP) to improve sensing and discrimination capabilities to reduce inappropriate shocks (IAS). SP status is programmable but may also be disabled automatically in the setting of low amplitude signals or low heart rate in order to avoid under-sensing of VT/VF. Objective To evaluate SP impact on IAS, appropriate shocks (AS), complications and mortality in the UNTOUCHED S-ICD trial. Methods Primary prevention patients (pts, n=1111) with ejection fraction ≤35% and no pacing requirement were followed for up to 18 months. SP status during a study visit was programmed ON or OFF and status between visits was either consistently OFF, ON, or automatically disabled (DIS). The impact of SP status on pt outcomes was evaluated using Kaplan-Meier (K-M) analysis. Multivariable proportional hazard analysis identified predictors of IAS and SP disable events. Results Percent of pts with SP always ON, always OFF, ON with DIS, and OFF then ON with no DIS were 56, 16, 15, and 13%, respectively. At least one SP DIS occurred in 177 pts, but only 13% had 2 or more, mostly due to PVCs and low EGM amplitudes. Significant multivariable predictors of SP disable events are history of atrial fibrillation (hazard ratio (HR) 2.49, odds ratio (OR) (1.49-4.16); p=.0005), only one passing vector at S-ICD screening, (HR 1.85, OR (1.10-3.10; p=.0202) and lower left ventricular ejection fraction (HR 1.05, OR (1.01-1.08); p=.0074). K-M IAS rates were highest for pts experiencing DIS (fig 1) and lowest for SP ON. While neither AS (p=0.58) nor complication (p=0.58) rates varied significantly according to SP status, mortality was lower for pts with SP ON during any duration of time (p=0.044) by univariate analysis. Further analysis is planned to better understand the relationship between SP status and mortality. Conclusion Patients in the UNTOUCHED trial with SMART Pass (SP) consistently ON had significantly fewer inappropriate shocks, with no impact on appropriate therapy for VT/VF. Patients with history of atrial fibrillation, lower left ventricular ejection fraction, and only one passing vector at S-ICD screening are at higher risk of SP disable events; therefore, care should be taken for these patients to assess SP status and their higher risk for inappropriate shocks.
ChemInform Abstract: Synthesis of Vitamin E Analogues: Possible Active Forms of Vitamin E. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Tracking adoptively transferred NK cells in rhesus macaques with 89Zr PET imaging. (2015)

225 Objectives Cell-based therapies against cancers have been rapidly progressing in recent years. Various techniques to enhance migration of transferred cells to the target have been explored. A non-invasive cell tracking method could help evaluate and optimize these techniques. We generated 89Zr-oxine complex cell labeling agent, evaluated the complex in rhesus macaque (RM) and human natural killer (NK) cells, and monitored an autologous NK cell transfer in RM by PET. Methods NK cells enriched from peripheral blood, by T-cell depletion, were expanded using irradiated feeder cells and human IL-2 for 14 days. 89Zr-oxine complex synthesized in an aqueous solution was used to label NK cells. Effects of labeling on surface phenotype and cytotoxicy were evaluated. 89Zr-labelled autologous NK cells (1.3×108 cells, 2.3 MBq) transferred to RM (5.7 kg) were tracked by a clinical PET/CT scanner up to 7 days. Deferoxamine was injected concurrently to chelate and enhance renal excretion of free 89Zr released from the dead cells. Results Expanded RM and human NK cells showed comparable surface phenotype and cytotoxic function. 89Zr-oxine readily permeabilized and was retained in NK cells. Labeling did not alter expression of CD16 and CD56 markers or cytotoxicity against K562 cells. PET/CT demonstrated that NK cells initially localized to the lungs, and gradually trafficked to the liver and spleen (SUV: 0.7, 17.0, and 20.1 for the lungs, liver and spleen on day 2) where they remained up to day 7. RM indicated no side effect. Conclusions The RM model indicated that 89Zr-oxine could visualize transferred cells at a low radioactivity dose on a clinical PET/CT imager. 89Zr-oxine complex would be a valuable tool for evaluating and optimizing various cell-based therapies and readily translational.
Telegraph-Diffusion Operator for Image Enhancement (2007)

Image denoising and enhancement problems have many physical analogues that highlight new approaches to novel solutions. One such solution, based on viewing the image as elastic sheet, is presented. A processing scheme for grayscale images is outlined and further considered in the context of color images. Preliminary analysis and simulations on noisy images indicate that multidimensional manifold representation of combined space-color information incorporates the advantages of separate color channel representations. Experimental analysis reveals elastic sheet method to be a powerful and robust denoising tool, which preserves most meaningful details.
<title>Embedded quasi-distributed sensor for composite material</title> (1993)

This work presents the first example of structure mode shapes recovering by means of an embedded quasi-distributed fiber-optic sensor. The developed feed-forward quasi-distributed polarimetric sensor allows a distributed recovery of the structure strain while maintaining low- invasivity, high-sensitivity, and high spatial resolution. The first three modes of a CRFP cantilever have been recovered both in frequency and in modal shape by means of the 8- segment sensor. The excellent agreement between the theoretical datum and the experimental results confirms the suitability of the presented architecture in developing advanced sensing systems for structure application.
Isolated Multi Level Virtual Conductor with Plug and Play Operation Using Bi-directional Dual Active Bridge Converter (2022)

To reduce management and expansion costs of the power system, plug and play approach can be used which reduces an effort to connect equipments. Among them, a DC power grid interconnection system called Multi Level Virtual Conductor can be used to realize a DC distribution system that allows free placement of equipment without communication. This paper studies an implementation of electrical isolated Multi Level Virtual Conductor using bidirectional Dual Active Bridge converters, which has not yet been realized. A small-signal model of the system was derived by dynamic analysis, and design guidelines for the control system were discussed. Also, DC buses with different voltage specifications were connected in a loop using the interconnection system through circuit simulation, and it was found that the power distribution was maintained flexibly regardless of either state changes of the components connected to each DC bus or disconnection of the power transmission route.
Circulating Biomarkers to Identify Responders in Cardiac Cell therapy (2017)

Bone marrow mononuclear cell (BM-MNC) therapy in ST-elevation acute myocardial infarction (STEMI) has no biological inclusion criteria. Here, we analyzed 63 biomarkers and cytokines in baseline plasma samples from 77 STEMI patients treated with BM-MNCs in the TIME and Late-TIME trials as well as 61 STEMI patients treated with placebo. Response to cell therapy was defined by changes in left ventricular ejection fraction, systolic/diastolic volumes, and wall motion indexes. We investigated the clinical value of circulating proteins in outcome prediction using significance testing, partial least squares discriminant analysis, and receiver operating characteristic (ROC) analysis. Responders had higher biomarker levels (76-94% elevated) than non-responders. Several biomarkers had values that differed significantly (P < 0.05) between responders and non-responders including stem cell factor, platelet-derived growth factor, and interleukin-15. We then used these lead candidates for ROC analysis and found multiple biomarkers with values areas under the curve >0.70 including interleukin 15. These biomarkers were not involved in the placebo-treated subjects suggesting that they may have predictive power. We conclude that plasma profiling after STEMI may help identify patients with a greater likelihood of response to cell-based treatment. Prospective trials are needed to assess the predictive value of the circulating biomarkers.
A Software Tool for Registration Based Distortion Correction in Echo Planar Imaging (2007)

There exists a need for more accurate functional localization through the registration of functional to anatomical magnetic resonance brain images. This paper introduces a new software tool, named NPTK, that has been developed at the Signal and Image Processing Laboratory of the University of Texas at Dallas for improved functional localization in single- subject analysis. This software toolkit is developed based on recently introduced non-rigid registration and field map distortion correction techniques, which has been validated via in-vivo validation of retrospective distortion correction in Echo- Planar Imaging. The paper provides an overview of the entire functional localization pipeline, an algorithmic description of the developed software, and a discussion on the performance and applications of the software.