gebhart/patrepeval huggingface dataset:
Effects of Caloric Restriction and Growth Hormone Resistance on the Expression Level of Peroxisome Proliferator-Activated Receptors Superfamily in Liver of Normal and Long-Lived Growth Hormone Receptor/Binding Protein Knockout Mice (2005)

Growth hormone receptor/binding protein knockout (GHR-KO) mice live approximately 40% longer than their normal siblings do. These mice have dramatically reduced plasma levels of insulin-like growth factor 1 (IGF1) and enhanced insulin sensitivity. We examined the expression level of peroxisome proliferator-activated receptors (PPARs) and retinoid X receptors family genes in the livers of normal and GHR-KO mice fed ad libitum or subjected to long-term 30% caloric restriction (CR). The levels of PPARgamma and PPARalpha messenger RNA and proteins and the levels of retinoid X receptors messenger RNA were elevated in long-lived GHR-KO mice as compared to normal mice with no major effect of CR in either genotype. These findings suggest that enhanced insulin sensitivity of GHR-KO mice may be related to the altered actions of PPARs family members in the liver. The results also indicate that CR may increase insulin sensitivity through a different mechanism.
Effect of Transition Curvature on Signal Quality for Narrow Track Recording (2010)

We investigated the effect of transition curvature on track edge noise through experiments and calculations. We measured and calculated two types of recording heads that had similar magnetic write widths, but different transition curvatures. In both the measurements and calculations, the track edge noise increased more at high linear density with the head with larger transition curvature, due to its wider erase band, which was considered to be noise source at the track edge. We also clarified that reducing the transition curvature was effective to increase signal-to-noise ratio (SNR), especially at high linear density, and that reducing the track edge fluctuation was effective to increase SNR, especially at low linear density. Therefore, reducing both the transition curvature and track edge fluctuation is necessary to reduce track edge noise and consequently achieve high areal density.
Surfactant Protein Genetic Marker Alleles Identify a Subgroup of Tuberculosis in a Mexican Population (2000)

Pulmonary surfactant and its components are essential for normal lung function and are involved in local host defense. Surfactant protein (SP)-A and SP-D bind to and modulate phagocytosis of Mycobacterium tuberculosis by macrophages. Frequency comparisons of SP marker alleles in tuberculosis patients and healthy control subjects (tuberculin-skin test positive or general population) were performed. Regression analyses of the tuberculosis and the tuberculin-skin test positive groups revealed, on the basis of odds ratios, tuberculosis susceptibility (DA11_C and GATA_3) and protective (AAGG_2) marker alleles. Similarly, between tuberculosis patients and general population control subjects, susceptibility 1A(3), 6A(4), and B1013_A and protective AAGG_1, and AAGG_7 marker alleles were observed. Moreover, interactions were seen between alleles 6A(2) and 1A(3) (P=.0064) and between 1A(3) and B1013_A (P=. 036). The findings indicate a possible involvement of SP alleles in tuberculosis pathogenesis.
PHD2 regulates arteriogenic macrophages through TIE2 signalling (2013)

Occlusion of the main arterial route redirects blood flow to the collateral circulation. We previously reported that macrophages genetically modified to express low levels of prolyl hydroxylase domain protein 2 (PHD2) display an arteriogenic phenotype, which promotes the formation of collateral vessels and protects the skeletal muscle from ischaemic necrosis. However, the molecular mechanisms underlying this process are unknown. Here, we demonstrate that femoral artery occlusion induces a switch in macrophage phenotype through angiopoietin-1 (ANG1)-mediated Phd2 repression. ANG blockade by a soluble trap prevented the downregulation of Phd2 expression in macrophages and their phenotypic switch, thus inhibiting collateral growth. ANG1-dependent Phd2 repression initiated a feed-forward loop mediated by the induction of the ANG receptor TIE2 in macrophages. Gene silencing and cell depletion strategies demonstrate that TIE2 induction in macrophages is required to promote their proarteriogenic functions, enabling collateral vessel formation following arterial obstruction. These results indicate an indispensable role for TIE2 in sustaining in situ programming of macrophages to a proarteriogenic, M2-like phenotype, suggesting possible new venues for the treatment of ischaemic disorders.
Perinatal Exposure to Purity-Controlled Polychlorinated Biphenyl 52, 138, or 180 Alters Toxicogenomic Profiles in Peripheral Blood of Rats after 4 Months (2013)

It is known from controlled animal experiments and human epidemiologic studies that early life exposure to mixtures of polychlorinated biphenyls (PCBs) is a risk factor for developmental neurotoxicity. The importance of non-dioxin-like PCBs in the context of the observed effect is uncertain because of the blending with the more potent dioxin-like PCBs. Previously, a controlled rat perinatal exposure study with individual, purity-controlled, non-dioxin-like congeners (PCB52, PCB138, or PCB180) was set up. Impaired motor coordination, motor activity, and learning has been reported for the offspring at an age of approximately 4 months. Here, we report on the gene expression responses that have been observed in the blood of the same animals. ANOVA analysis called 1412 genes differentially expressed 4 months after the PCB treatment was stopped. Subsequently, each PCB exposure condition was compared to the corresponding vehicle control using a fold change analysis. The gene lists contained between 82 and 348 differentially expressed genes. Expression patterns were complex with sets of differentially expressed genes being specific for a particular PCB exposure and other sets in common between several exposure conditions. Thirty-two genes were differentially expressed under all conditions. Bioinformatic overrepresentation analysis identified enriched biological terms such as lipid metabolism, molecular transport, small molecule biochemistry, and cell signaling and proliferation. Gene lists were particularly enriched for nervous system development and function ontology. In conclusion, we have documented for the first time differential gene expression in a well-controlled animal study that reported behavioral effects of purity-controlled individual non-dioxin-like PCBs.
In vivo optical imaging of folate receptor‐β in head and neck squamous cell carcinoma (2014)

Although HNSCC tumor cells do not express FR, HNSCC tumors contain a significant population of FR-β-expressing macrophages. Folate conjugated fluorescent dye is able to specifically target and label tumor xenografts to permit macroscopic fluorescence imaging due to FR-β expression on the infiltrating inflammatory cells.
Novel Quinoline-Based P2–P4 Macrocyclic Derivatives As Pan-Genotypic HCV NS3/4a Protease Inhibitors (2014)

We have previously reported the discovery of our P2-P4 macrocyclic HCV NS3/4a protease inhibitor MK-5172, which in combination with the NS5a inhibitor MK-8742 recently received a breakthrough therapy designation from the US FDA for treatment of chronic HCV infection. Our goal for the next generation NS3/4a inhibitor was to achieve pan-genotypic activity while retaining the pharmacokinetic profile of MK-5172. One of the areas for follow-up investigation involved replacement of the quinoxaline moiety in MK-5172 with a quinoline and studying the effect of substitution at 4-position of the quinoline. The rationale for this effort was based on molecular modeling, which indicated that such modifications would improve interactions with the S2 subsite, in particular with D79. We wish to report herein the discovery of highly potent inhibitors with pan-genotypic activity and an improved profile over MK-5172, especially against gt-3a and A156 mutants.
Sterilization of propylene/ethylene random copolymers: Annealing effects on crystalline structure and transparency as influenced by polymer structure and nucleation (2011)

An extensive investigation of three different series of isotactic ethylene/propylene (EP) random copolymers was performed to understand the factors influencing the change in optical properties in the steam sterilization of extrusion cast films from such materials. Different analytical methods (differential scanning calorimetry (DSC), X-ray diffraction and electron microscopy) were employed to elucidate structural changes determining film optics, and in addition to the polymer structure parameters also nucleation and processing effects were studied. The findings clearly show that a combination of homogeneously randomized comonomer distribution and nucleation can partly inhibit lamellar thickening in sterilization, thus preserving high transparency even after a heat treatment. In detail, attention has to be paid to the combined effects of primary and secondary post-crystallization, which both are affected by the chain regularity.
A cerium(III) modification of the Peterson reaction: methylenation of readily enolizable carbonyl compounds (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA cerium(III) modification of the Peterson reaction: methylenation of readily enolizable carbonyl compoundsCarl R. Johnson and Bradley D. TaitCite this: J. Org. Chem. 1987, 52, 2, 281–283Publication Date (Print):January 1, 1987Publication History Published online1 May 2002Published inissue 1 January 1987https://pubs.acs.org/doi/10.1021/jo00378a024https://doi.org/10.1021/jo00378a024research-articleACS PublicationsRequest reuse permissionsArticle Views3711Altmetric-Citations107LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Istvan Bethlen: A Great Conservative Statesman of Hungary, 1874-1946 (1999)

This study provides an account of the work of Count Istvan Bethlen, the chief architect of the interwar conservative political system in Hungary. It details his policies, which improved Hungary's internal and external position.
Development of a Broad-Based ADME Panel for Use in Pharmacogenomic Studies (2014)

Over the course of three design iterations, overall assay conversion rates were improved from 83 to 97% resulting in a panel that fills in many of the gaps in coverage present on currently available commercial genotyping assays. The utility of the assay has been demonstrated by the screening of more than 1000 samples resulting in the discovery of novel pharmacogenomic associations. The assay, and the underlying methods, will continue to be a valuable tool for use in future pharmacogenomic studies.
Structure-Guided Chemical Optimization of Bicyclic Peptide (Bicycle) Inhibitors of Angiotensin-Converting Enzyme 2 (2023)

Angiotensin-converting enzyme 2 (ACE2) is a metalloprotease that cleaves angiotensin II, a peptide substrate involved in the regulation of hypertension. Here, we identified a series of constrained bicyclic peptides, <i>Bicycle</i>, inhibitors of human ACE2 by panning highly diverse bacteriophage display libraries. These were used to generate X-ray crystal structures which were used to inform the design of additional <i>Bicycles</i> with increased affinity and inhibition of ACE2 enzymatic activity. This novel structural class of ACE2 inhibitors is among the most potent ACE2 inhibitors yet described <i>in vitro</i>, representing a valuable tool to further probe ACE2 function and for potential therapeutic utility.
Modeling, design, and analysis of interferometric cantilevers for time-resolved force measurements in tapping-mode atomic force microscopy (2011)

Cantilevers with interferometric high bandwidth force sensors can resolve nonlinear tip-sample interaction forces in tapping-mode atomic force microscopy. In this paper, we provide a detailed analysis of time-resolved force measurements using such cantilever. We first model the probe as a coupled spring-mass system and investigate its steady state dynamics under tapping-mode imaging conditions. Next, we analyze the optical response of the interferometric force sensor: Diffraction patterns as a function of tip displacement are obtained both analytically and by simulations. Finally, the frequency response of the force sensor is calculated, and the effects of the sensor geometry variations on the sensor mechanical response are analyzed.
The Comparison of Ultrasonic Doppler Method and Wire Mesh Tomography in bubbly flow measurement (2003)

In this paper, combination measurement of ultrasonic Doppler method (UDM) and wire mesh tomography (WMT) techniques for two-phase bubbly flow measurement are proposed. The UDM can measure instantaneous velocity profiles along its measuring line. By applying statistical methods, the UDM can obtain liquid parameters in bubbly flow. The WMT is based on local conductivity measurement and can measure the two-dimensional void fraction distribution and bubble diameter. Using both techniques at the same conditions, the effects of the seeding particles in the liquid as reflector of ultrasonic are investigated. Furthermore, the void fraction is measured by taking the bubble diameter as the parameter. The measurement results clarified that bubble size plays very important roles for two-phase structures and the effectiveness of these techniques are shown.
A Policy Evaluation Tool for Multisite Resource Management (2008)

An enterprise typically operates multiple data center sites, each handling workloads according to an enterprise-level strategy. Sharing resources across multiple sites (or enterprises) brings up several important problems. Each site may have its own policies that govern its interactions with other remote sites. Different policies impact the system performance in different ways. The site administrators and system designers need to understand the effects of a given set of policies on different workloads. In this paper, we describe an analysis methodology that determines the impact of policies on the workloads, and we present results and validation for a prototypical multi-site resource sharing system. Our analytical tool is capable of evaluating complex policies on a large scale system and permits independent policies for each site, so that policy makers can quickly evaluate several alternatives and their effects on the workloads before deploying them.
Laser-phase-fluctuation-insensitive offset-frequency-spaced two-tone optical coherent detection scheme with digital-signal-processing technique for radio-over-fiber systems (2015)

We have proposed a laser-phase-fluctuation-insensitive optical coherent detection scheme assisted by a digital signal processing (DSP) technique for radio-over-fiber (RoF) systems. In this system, a “two-tone” local light is used for an individual optical coherent detection of both the carrier and the modulated components of RoF signal, where a frequency separation of two-tone local light is the same as that of RoF signal. To distinguish the carrier and the modulated components in the process of optical coherent detection, they have to be separated in the optical domain. In this paper, we proposed a new optical coherent detection scheme with an “offset-frequency-spaced two-tone” local light, which is also in principle insensitive to the laser phase fluctuation and is assisted by the DSP technique. In the proposed scheme, it is not required to separate the carrier and the modulated components in the optical domain because they can be easily separated in the electrical domain after the photodetection. Therefore, the system configuration is expected to be simpler than that in the previous scheme. First, we explain the principle of our new proposal and experimentally demonstrate the data recovery. Then, the influence of the frequency detuning between photo-detected modulated and unmodulated signals is discussed. Moreover, the transmission performance with an error vector magnitude (EVM) is also evaluated for the optical coherent detection of a 10-Gbaud quadrature-phase-shift-keying RoF signal after a 20-km-long standard single-mode fiber transmission. As a result, it is shown that the EVM of less than 12.4 %rms is achieved.
Are Disposable and Standard Gonioscopy Lenses Comparable? (2017)

We conclude that there is no significant difference in quality of images produced with standard versus disposable gonioscopy lenses. Disposable gonioscopy lenses may be an acceptable alternative to standard reusable lenses, especially in conditions where sterilization is difficult.
Safe Distribution and Parallel Execution of Data-Centric Workflows over the Publish/Subscribe Abstraction (2015)

In this work, we develop an approach for the safe distribution and parallel execution of data-centric workflows over the publish/subscribe abstraction. In essence, we design a unique representation of data-centric workflows, specifically designed to exploit the loosely coupled and distributed nature of publish/subscribe systems. Furthermore, we argue for the practicality and expressiveness of our approach by mapping a standard and industry-strength data-centric workflow model, namely, IBM Business Artifacts with Guard-Stage-Milestone (GSM), into the publish/subscribe abstraction. In short, the contributions of this work are three-fold: (1) mapping of data-centric workflows into publish/subscribe to achieve distributed and parallel execution; (2) detailed theoretical analysis of the mapping; and (3) formulation of the complexity of the optimal workflow distribution over the publish/subscribe abstraction as an NP-hard problem.
5G Media Data System Architecture (2020)

<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">The existing 3rd Generation Partnership Project (3GPP) packet- switched streaming (PSS) architecture that was developed for 3G and 4G and evolved to carry streaming content with DASH [Dynamic and Adaptive Streaming over Hypertext Transfer Protocol (HTTP)], is now seen as too limited for 5G. 3GPP has, therefore, started developing a new media streaming architecture, considering the latest advances in the media industry and the features offered by the 5G system. Recognizing that, most media and video content delivered to the user is provided by several online service providers, the new 3GPP 5G media streaming architecture focuses on different collaboration and deployment models between mobile network operators and media data service providers. These collaboration and deployment models also cater to traditional broadcasters, which increasingly see the need for high-quality contributions via a mobile network, for example, to cover unplanned or transient events. The new architecture supports unicast downlink media data distribution and uplink streaming</i> .
Influence of farnesol on the morphogenesis of Aspergillus niger (2008)

Farnesol was the first quorum-sensing regulator to be found in eukaryotic cells. In Candida albicans, a dimorphic fungal human pathogen, farnesol blocks the yeast-to-filamentous growth transition. Here we show that in Aspergillus niger farnesol acts as an inhibitor of conidiation: Colonies grown on media containing farnesol were unable to develop conidia. Although farnesol treated A. niger cultures exhibited a colony morphology resembling the "fluffy" phenotype of A. nidulans, which is caused by a hyperactive G-protein/cAMP pathway, the intracellular level of cAMP in A. niger mycelia grown in presence of farnesol is greatly diminished. Furthermore, whereas inhibiting adenylyl cyclase led to a farnesol-like effect, the addition of external cAMP inhibited conidiation without causing a "fluffy" phenotype. This suggests that the mechanisms regulating conidiation in A. niger and A. nidulans are different.
Optical and Electrical Properties of CuInS2 Thin Films by Spray Pyrolysis (1984)

The optical, electrical and structural properties of CuInS 2 thin films prepared by spray pyrolysis have been studied. The polycrystalline films produced by spraying a solution of Cu (CH 3 COO) 2 H 2 O, InCl 3 and (NH 2 ) 2 CS with the atomic ratio Cu:In:S=1:1:2.8∼1:1:3.2 and annealing at 500°C for 2 hours were nearly stoichiometric, and the depth profiles of the atomic composition were flat except near the surface. The optical band gap at room temperature was 1.43 eV, and the polarity of the thermoelectromotive force showed p-type conduction at a sulfur concentration ratio to Cu[S]≥2.8. The activation energy of conductivity was 0.3 eV.
T-cell Responses to HSV-1 in Persons Who Have Survived Childhood Herpes Simplex Encephalitis (2017)

The defects in cell-intrinsic immunity leading to failure to control primary central nervous system HSV-1 infection do not preclude the acquisition of specific immunity or the control of recurrent mucocutaneous HSV infections. The rarity and lack of severe or recurrent mucocutaneous HSV infection in survivors of childhood HSE corresponds with intact adaptive T-cell immunity.
05101 Abstracts Collection – Scheduling for Parallel Architectures: Theory, Applications, Challenges (2005)

From 06.03.05 to 11.03.05, the Dagstuhl Seminar 05101 ``Scheduling for Parallel Architectures: Theory, Applications, Challenges'' was held in the International Conference and Research Center (IBFI), Schloss Dagstuhl. During the seminar, several participants presented their current research, and ongoing work and open problems were discussed. Abstracts of the presentations given during the seminar as well as abstracts of seminar results and ideas are put together in this paper. The first section describes the seminar topics and goals in general.
The performance of ensemble-based free energy protocols in computing binding affinities to ROS1 kinase (2022)

Optimization of binding affinities for compounds to their target protein is a primary objective in drug discovery. Herein we report on a collaborative study that evaluates a set of compounds binding to ROS1 kinase. We use ESMACS (enhanced sampling of molecular dynamics with approximation of continuum solvent) and TIES (thermodynamic integration with enhanced sampling) protocols to rank the binding free energies. The predicted binding free energies from ESMACS simulations show good correlations with experimental data for subsets of the compounds. Consistent binding free energy differences are generated for TIES and ESMACS. Although an unexplained overestimation exists, we obtain excellent statistical rankings across the set of compounds from the TIES protocol, with a Pearson correlation coefficient of 0.90 between calculated and experimental activities.