gebhart/patrepeval huggingface dataset:
A New and Facile Method To Prepare Uniform Hollow MnO/Functionalized mSiO2 Core/Shell Nanocomposites (2011)

Trifunctional uniform nanoparticles comprising a manganese nanocrystal core and a functionalized mesoporous silica shell (MnO@mSiO(2)(Ir)@PEG, where Ir is an emissive iridium complex and PEG is polyethylene glycol) have been strategically designed and synthesized. The T(1) signal can be optimized by forming hollow core (H-MnO@mSiO(2)(Ir)@PEG) via a novel and facile etching process, for which the mechanism has been discussed in detail. Systematic investigation on correlation for longitudinal relaxation (T(1)) versus core shapes and shell silica porosity of the nanocomposites (MnO, H-MnO, MnO@SiO(2), MnO@mSiO(2), H-MnO@mSiO(2)) has been carried out. The results show that the worm-like nanochannels in the mesoporous silica shell not only increase water permeability to the interior hollow manganese oxide core for T(1) signal but also enhance photodynamic therapy (PDT) efficacy by enabling the free diffusion of oxygen. Notably, the H-MnO@mSiO(2)(Ir)@PEG nanocomposite with promising r(1) relaxivity demonstrates its versatility, in which the magnetic core provides the capability for magnetic resonance imaging, while the simultaneous red phosphorescence and singlet oxygen generation from the Ir complex are capable of providing optical imaging and inducing apoptosis, respectively.
Self-tuning digitally controlled low-harmonic rectifier having fast dynamic response (2003)

This paper describes a completely digitally controlled high-performance low-harmonic rectifier. It is shown that the dynamics of the outer voltage loop can be significantly improved using a self-tuning digital comb filter. Low input current harmonics and fast voltage transient responses are experimentally verified on a 200 W universal-input boost rectifier operating at the switching frequency of 200 kHz.
Small ion-driven VUV/UV light sources for laboratory applications (2004)

Inertial electrostatic confinement (IEC) devices offer a unique method to generate energetic ions for excitation of rare gas and rare gas halide excimers. A unique feature for this approach is that it allows small sized units with the ion source and excimer medium contained in vessels of order 30-cm radius. The IEC operates by applying a high negative voltage (up to -100 kV) on a spherical mesh grid (cathode) located in the center of a grounded grid (anode), all within a spherical vacuum vessel. A plasma discharge is created between the grids. The cathode extracts ions from the discharge and accelerates them towards the center of the device. Large ion background gas collision densities are created in the center region and along the ion beam paths, creating intense light emission. An alternate approach discussed here allow lower operating pressures and reduced ion thermalization, giving improved emission efficiencies, uses an external RF ion generator to separate the injected species from the mixture. The injector increases the device size, but a compact RF source has been developed which involves injector diameters of only ~ 6 cm by 30- cm length. Designs for such devices and their operation will be described.
Surface Roughness Measurements Of Curved Surfaces By Light Scatter (1982)

The use of light scatter to determine flat surface statistical information, such as a bandwidth limited section of the surface power spectral density (PSD) function and the associated rms roughness and slope numbers, is well documented in the literature. Systems which mea-sure scatter as a function of angular position often make use of the fact that the surface power spectral density function is essentially produced in the scatter pattern. Low spatial frequencies scatter close to the direc-tion of specular reflection and higher frequencies scatter further out. The technique relies on the one-to-one relationship between spatial frequen-cy and scatter position in the far field. This relationship is exact to within dimensions corresponding to the diffraction limit (i.e., dimensions much smaller than the usual detector aperture). For a curved surface, this one-to-one relationship is destroyed as scatter from a single spatial frequency can spread out to dimensions far exceeding those of a diffraction limited spot. As the spread approaches detector aperture dimensions, the ability to extract useful surface information is impaired. The amount of spread is determined by the illuminated spot radius r, the radius of curvature of the surface R, and the angle of incidence 01(r) and is plotted, for constant 01, as a function of r/R. Analytical data show that by reducing r to 0.5 mm, reasonable results are obtainable with workable scatter system geometries for curved surfaces with R _> 5 cm.
On spectral design methods for quasi-cyclic codes (2016)

A method is provided for constructing upper-triangular square matrices over the univariate polynomial ring over a finite field, under certain constraints on the eigenvalues of the matrices. In some cases of interest, the degree of the determinant of such matrices is shown to be the smallest possible. The method is then applied to construct generator polynomial matrices of quasi-cyclic codes with a prescribed designed minimum distance.
Joint routing and scheduling in dense small cell networks using 60 GHz backhaul (2015)

This paper addresses the problem of joint routing and backhaul link scheduling in a dense small cell network using 60GHz multi-hop backhaul, coordinated by a local Cloud-RAN central unit. Our objective is to optimally select the backhaul links and paths to be activated in time domain to enhance the cell throughput and to minimize the total delay, considering the backhaul channel conditions and the Quality of Service requirements. This problem is formulated as a generalized vehicle routing problem and decoupled into two sub-problems: channel-aware path selection and queue-aware link scheduling. The path selection sub-problem is solved optimally using Branch-and-Cut exact algorithm for a given number of paths with per-link delay bounds. Subsequently, the scheduling sub-problem is solved using back-pressure scheduling.
Regulation of 130-kDa Smooth Muscle Myosin Light Chain Kinase Expression by an Intronic CArG Element (2013)

The mylk1 gene encodes a 220-kDa nonmuscle myosin light chain kinase (MLCK), a 130-kDa smooth muscle MLCK (smMLCK), as well as the non-catalytic product telokin. Together, these proteins play critical roles in regulating smooth muscle contractility. Changes in their expression are associated with many pathological conditions; thus, it is important to understand the mechanisms regulating expression of mylk1 gene transcripts. Previously, we reported a highly conserved CArG box, which binds serum response factor, in intron 15 of mylk1. Because this CArG element is near the promoter that drives transcription of the 130-kDa smMLCK, we examined its role in regulating expression of this transcript. Results show that deletion of the intronic CArG region from a β-galactosidase reporter gene abolished transgene expression in mice in vivo. Deletion of the CArG region from the endogenous mylk1 gene, specifically in smooth muscle cells, decreased expression of the 130-kDa smMLCK by 40% without affecting expression of the 220-kDa MLCK or telokin. This reduction in 130-kDa smMLCK expression resulted in decreased phosphorylation of myosin light chains, attenuated smooth muscle contractility, and a 24% decrease in small intestine length that was associated with a significant reduction of Ki67-positive smooth muscle cells. Overall, these data show that the CArG element in intron 15 of the mylk1 gene is necessary for maximal expression of the 130-kDa smMLCK and that the 130-kDa smMLCK isoform is specifically required to regulate smooth muscle contractility and small intestine smooth muscle cell proliferation.
Structural Development and Multiscale Design Optimization of Additively Manufactured UAV with Blended Wing Body Configuration Employing Lattice Materials (2019)

The research work presented in this paper is developed by the Blended Wing Body (BWB) Unmanned Aerial Vehicle (UAV) team, a fourth-year capstone project at Carleton University Department of Mechanical and Aerospace Engineering. Here, a clean sheet UAV with BWB configuration is designed and optimized using Multiscale Design Optimization (MSDO) approach employing lattice materials taking into consideration design for additive manufacturing constraints. The BWB-UAV is being developed with a mission profile designed for surveillance purposes with a minimum payload of 1000 grams. To demonstrate the design methodology, a single design loop of a sample rib from the airframe is shown in details. This included presentation of the conceptual design, materials selection, experimental characterization and residual thermal stress distribution analysis of additively manufactured materials, identification of the manufacturing constraints, critical loads computations, stress analysis and design optimization. Critical loads envelop was identified. A time consistent dynamic turbulent critical load case was recognized as the design load case for the presented wing rib. The identified load case is composed of a 1-g static maneuver with an incremental Power Spectral Density (PSD) gust which was used as a deterministic design load case for the design optimization of the wing rib. 2D flat plate Doublet Lattice Method (DLM) was used to simulate aerodynamics in the aeroelastic analysis. The aerodynamic results were verified versus a 3D CFD analysis applying Spalart-Allmaras and SST k-omega turbulence to the rigid UAV and vortex lattice method applied in the OpenVSP environment. Design optimization of the wing rib was conducted using topology optimization as well as MSDO employing lattice materials. Compared to a solid rib, weight savings of 36.44% and 59.65% were obtained for the topology optimization and the MSDO, respectively. These results suggest that MSDO is a promising alternative to topology optimization in weight critical applications while preserving structural functional requirements.
Ultra-broadband Spectral Beam Combiner (2015)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text E. J. Stanton, M. J. R. Heck, J. Bovington, A. Spott, and J. E. Bowers, "Ultra-broadband Spectral Beam Combiner," in CLEO: 2015, OSA Technical Digest (online) (Optica Publishing Group, 2015), paper AF1E.3. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
ChemInform Abstract: Dithiadiazafulvalenes ‐ New Strong Electron Donors. Synthesis, Isolation, Properties, and EPR Studies. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Integrins and signal transduction in platelets (1995)

Journal Article Integrins and signal transduction in platelets Get access Edward F. Plow Edward F. Plow Center for Thrombosis and Vascular Biology, The Cleveland Clinic Foundation, Cleveland, Ohio Search for other works by this author on: Oxford Academic Google Scholar Stem Cells, Volume 13, Issue 1, January 1995, Page 91, https://doi.org/10.1002/stem.5530130117 Published: 01 January 1996
Comparative genomic analysis of C4 photosynthetic pathway evolution in grasses (2009)

Gene duplication followed by functional innovation is common to evolution of most but not all C4 genes. The apparently long time-lag between the availability of duplicates for recruitment into C4 and the appearance of C4 grasses, together with the heterogeneity of origins of C4 genes, suggests that there may have been a long transition process before the establishment of C4 photosynthesis.
Inverse Kinematic Solutions of Free-Floating Closed-Chain Planar Manipulators (1991)

Abstract This paper deals with inverse solutions of free-floating closed-chain planar manipulators. The problem, in essence, is to compute the joint angles given the position and orientation of the end-effector. For free-floating planar manipulators, in the absence of external forces and couples, the linear and angular momentum are conserved. This makes the solution procedure and the number of inverse solutions for free-floating manipulators different from those of corresponding fixed-base manipulators. In order to illustrate this, we present the inverse kinematics of a free-floating planar manipulator whose end-effector is coupled to a base link by two R-R-R series chains. From the analysis, we conclude that for a given position and orientation of the end-effector, the location of the center of mass of the mechanism, and the orientation of the base link, upto 16 solutions of the joint angles are possible. To contrast, a fixed base manipulator of the same structure has a maximum of four solutions.
Supplementary Tables from Inhibition of the Nuclear Export Receptor XPO1 as a Therapeutic Target for Platinum-Resistant Ovarian Cancer (2023)

&lt;p&gt;Supplementary Table 1. cBIO data for XPO1 overexpression and association with survival. Supplementary Table 2. Clinical features of patient samples in TMA. Supplementary Table 3. Clinicopathologic features for patient-derived tumor cell lines.&lt;/p&gt;
Incentive Networks (2015)

In a basic economic system, each participant receives a (financial) reward according to his own contribution to the system. In this work, we study an alternative approach — Incentive Networks — in which a participant's reward depends not only on his own contribution; but also in part on the contributions made by his social contacts or friends. We show that the key parameter effecting the efficiency of such an Incentive Network-based economic system depends on the participant's degree of directed altruism. Directed altruism is the extent to which someone is willing to work if his work results in a payment to his friend, rather than to himself. Specifically, we characterize the condition under which an Incentive Network-based economy is more efficient than the basic "pay-for-your-contribution" economy. We quantify by how much incentive networks can reduce the total reward that needs to be paid to the participants in order to achieve a certain overall contribution. Finally, we study the impact of the network topology and various exogenous parameters on the efficiency of incentive networks. Our results suggest that in many practical settings, Incentive Network-based reward systems or compensation structures could be more efficient than the ubiquitous 'pay-for-your-contribution' schemes.
Trabajo, contrato y libertad: estudios jurídicos en memoria de Ignacio Albiol (2010)

espanolEste volumen se publica en recuerdo a Ignacio Albiol, licenciado y doctor en Derecho por la Universitat de Valencia, fallecido en 2009. Albiol es autor de numerosos manuales, monografias, recopilaciones jurisprudenciales y articulos de revista sobre temas de su especialidad, en la que consiguio el maximo reconocimiento por su actividad investigadora. Mas alla de constituir ejes tematicos de la obra de Ignacio Albiol durante mas de nueve lustros de dedicacion universitaria, trabajo, contrato y libertad pueden considerarse caracteristicas esenciales de la forma en que el profesor Albiol desarrollaba su actividad, y del modo en el que se presentaba ante el resto de la comunidad academica. catalaAquest volum es publica en record a Ignacio Albiol, llicenciat i doctor en Dret per la Universitat de Valencia, que va morir en 2009. Albiol es autor de nombrosos manuals, monografies, recopilacions jurisprudencials i articles de revista sobre temes de la seua especialitat, en la que va aconseguir el maxim reconeixement per la seua activitat investigadora. Mes enlla de constituir eixos tematics de l'obra d'Ignacio Albiol durant mes de nou lustres de dedicacio universitaria, treball, contracte i llibertat poden considerar-se caracteristiques essencials de la forma en que el professor Albiol desenvolupava la seua activitat, i de la manera en el que es presentava davant la resta de la comunitat academica.
Design of several un-skewed radial flux permanent magnet synchronous motors with asymmetric and symmetric AC windings &#x2014; A comparative study (2014)

A detailed comparative study on several un-skewed surface mounted permanent magnet motors including asymmetric and symmetric winding structures are completed in this paper. Motors with integer and “almost integer” slot are designed and compared using 2D FEA. The goal of obtaining low cogging, high quality torque output and sinusoidal back EMF are investigated for various motors without complicating the design with skewing. Some of the designed motor prototypes have been built, tested and compared with experimental data. The results show that obtaining high quality torque output, zero cogging and sinusoidal back-EMF is possible even with no skew for integer (or almost integer) slot PM motors.
The mathematical model of subtractive hybridization and its practical application. (1996)

A novel theory of subtractive hybridization including (or based on) the kinetic model of this process was proposed. A computer program modeling the process of subtraction was developed. Basing on the theory, a novel method of subtractive hybridization was proposed allowing routine comparison of genomes and products of genome expression. The method was applied to studies of the genetic mechanisms of embryogenesis, regeneration, cell differentiation and tumor transformation.
Adult Pgf−/− mice behaviour and neuroanatomy are altered by neonatal treatment with recombinant placental growth factor (2019)

Offspring of preeclamptic pregnancies have cognitive alterations. Placental growth factor (PGF), is low in preeclampsia; reduced levels may affect brain development. PGF-null mice differ from normal congenic controls in cerebrovasculature, neuroanatomy and behavior. Using brain imaging and behavioral testing, we asked whether developmentally asynchronous (i.e. neonatal) PGF supplementation alters the vascular, neuroanatomic and/or behavioral status of Pgf<sup>-/-</sup> mice at adulthood. C57BL/6-Pgf<sup>-/-</sup> pups were treated intraperitoneally on postnatal days 1-10 with vehicle or PGF at 10 pg/g, 70 pg/g or 700 pg/g. These mice underwent behavioral testing and perfusion for MRI and analysis of retinal vasculature. A second cohort of vehicle- or PGF-treated mice was perfused for micro-CT imaging. 10 pg/g PGF-treated mice exhibited less locomotor activity and greater anxiety-like behavior relative to vehicle-treated mice. Depressive-like behavior showed a sex-specific, dose-dependent decrease and was lowest in 700 pg/g PGF-treated females relative to vehicle-treated females. Spatial learning did not differ. MRI revealed smaller volume of three structures in the 10 pg/g group, larger volume of seven structures in the 70 pg/g group and smaller volume of one structure in the 700 pg/g group. No cerebral or retinal vascular differences were detected. Overall, neonatal PGF replacement altered behavior and neuroanatomy of adult Pgf<sup>-/-</sup> mice.
Sensors for Breath Testing: From Nanomaterials to Comprehensive Disease Detection (2013)

The analysis of volatile organic compounds in exhaled breath samples represents a new frontier in medical diagnostics because it is a noninvasive and potentially inexpensive way to detect illnesses. Clinical trials with spectrometry and spectroscopy techniques, the standard volatile-compound detection methods, have shown the potential for diagnosing illnesses including cancer, multiple sclerosis, Parkinson's disease, tuberculosis, diabetes, and more via breath tests. Unfortunately, this approach requires expensive equipment and high levels of expertise to operate the necessary instruments, and the tests must be done quickly and use preconcentration techniques, all of which impede its adoption. Sensing matrices based on nanomaterials are likely to become a clinical and laboratory diagnostic tool because they are significantly smaller, easier-to-use, and less expensive than spectrometry or spectroscopy. An ideal nanomaterial-based sensor for breath testing should be sensitive at very low concentrations of volatile organic compounds, even in the presence of environmental or physiological confounding factors. It should also respond rapidly and proportionately to small changes in concentration and provide a consistent output that is specific to a given volatile organic compound. When not in contact with the volatile organic compounds, the sensor should quickly return to its baseline state or be simple and inexpensive enough to be disposable. Several reviews have focused on the methodological, biochemical, and clinical aspects of breath analysis in attempts to bring breath testing closer to practice for comprehensive disease detection. This Account pays particular attention to the technological gaps and confounding factors that impede nanomaterial-sensor-based breath testing, in the hope of directing future research and development efforts towards the best possible approaches to overcome these obstacles. We discuss breath testing as a complex process involving numerous steps, each of which has several possible technological alternatives with advantages and drawbacks that might affect the performance of the nanomaterial-based sensors in a breath-testing system. With this in mind, we discuss how to choose nanomaterial-based sensors, considering the profile of the targeted breath markers and the possible limitations of the approach, and how to design the surrounding breath-testing setup. We also discuss how to tailor the dynamic range and selectivity of the applied sensors to detect the disease-related volatile organic compounds of interest. Finally, we describe approaches to overcome other obstacles by improving the sensing elements and the supporting techniques such as preconcentration and dehumidification.
Technical challenges for the future of high energy lasers (2007)

The Solid-State, Heat-Capacity Laser (SSHCL) program at Lawrence Livermore National Laboratory is a multi-generation laser development effort scalable to the megawatt power levels with current performance approaching 100 kilowatts. This program is one of many designed to harness the power of lasers for use as directed energy weapons. There are many hurdles common to all of these programs that must be overcome to make the technology viable. There will be a in-depth discussion of the general issues facing state-of-the-art high energy lasers and paths to their resolution. Despite the relative simplicity of the SSHCL design, many challenges have been uncovered in the implementation of this particular system. An overview of these and their resolution are discussed. The overall system design of the SSHCL, technological strengths and weaknesses, and most recent experimental results will be presented.
Modular Synthesis of Isoxazolopyridones and Pyrazolopyridones. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.