gebhart/patrepeval huggingface dataset:
In‐memory distributed software solution to improve the performance of recommender systems (2016)

Summary Many recommender systems are currently available for proposing content (movies, TV series, music, etc.) to users according to different profiling metrics, such as ratings of previously consumed items and ratings of people with similar tastes. Recommendation algorithms are typically executed by powerful servers, as they are computationally expensive. In this paper, we propose a new software solution to improve the performance of recommender systems. Its implementation relies heavily on Apache Spark technology to speed up the computation of recommendation algorithms. It also includes a webserver, an API REST, and a content cache. To prove that our solution is valid and adequate, we have developed a movie recommender system based on two methods, both tested on the freely available Movielens and Netflix datasets. Performance was assessed by calculating root‐mean‐square error values and the times needed to produce a recommendation. We also provide quantitative measures of the speed improvement of the recommendation algorithms when the implementation is supported by a computing cluster. The contribution of this paper lies in the fact that our solution, which improves the performance of competitor recommender systems, is the first proposal combining a webserver, an API REST, a content cache and Apache Spark technology. Copyright © 2016 John Wiley &amp; Sons, Ltd.
An interesting synthesis of thieno[2,3‐d][1,2,3]thiadiazole via decomposition/recyclization of 3‐methoxycarbonyl‐1H‐thieno‐[2,3‐e][1,3,4]thiadiazine 4,4‐dioxide (2000)

Abstract Attempted hydrolysis of the ester of 3‐methoxycarbonyl‐1 H ‐thieno[2,3‐ e ][1,3,4]thiadiazine 4,4‐dioxide ( I ) under acidic conditions gave the ring‐contracted thieno[2,3‐ d ][1,2,3]thiadiazole ( V ) instead of the expected carboxylic acid. In addition to a discussion of the reaction, a plausible mechanism is presented.
Theory of patch inverse boundary element method (IBEM) (2005)

Near-field acoustical holography (NAH) based on boundary element methods require the measurement of the near-field pressure field over a conformal and close surface in order to recover the acoustic field on a nearby surface. In this work a new technique called patch IBEM is introduced. This new technique eliminates the need to measure over an entire closed surface, but instead the measurements are taken over a small area to reconstruct the acoustic field. Patch IBEM is used for the reconstruction of the acoustic field over a fuselage panel in a Boeing 757 aircraft, using measurement taken at Boeing’s interior noise test facility (INTF). The measurements taken include a 120 mikes planar array positioned conformal to the fuselage panel surface and a 50 mikes spherical array. Results will be showed when the fuselage panel is excited by a shaker. [Work supported by ONR and NASA.]
Death by Gun Violence—A Public Health Crisis (2017)

subjective awareness of memory function or, as the authors conjecture, more advanced progression leading to reduced awareness of subtle deficits.
Identifying Actionable Targets through Integrative Analyses of GEM Model and Human Prostate Cancer Genomic Profiling (2014)

Abstract Copy-number alterations (CNA) are among the most common molecular events in human prostate cancer genomes and are associated with worse prognosis. Identification of the oncogenic drivers within these CNAs is challenging due to the broad nature of these genomic gains or losses which can include large numbers of genes within a given region. Here, we profiled the genomes of four genetically engineered mouse prostate cancer models that reflect oncogenic events common in human prostate tumors, with the goal of integrating these data with human prostate cancer datasets to identify shared molecular events. Met was amplified in 67% of prostate tumors from Pten p53 prostate conditional null mice and in approximately 30% of metastatic human prostate cancer specimens, often in association with loss of PTEN and TP53. In murine tumors with Met amplification, Met copy-number gain and expression was present in some cells but not others, revealing intratumoral heterogeneity. Forced MET overexpression in non–MET-amplified prostate tumor cells activated PI3K and MAPK signaling and promoted cell proliferation and tumor growth, whereas MET kinase inhibition selectively impaired the growth of tumors with Met amplification. However, the impact of MET inhibitor therapy was compromised by the persistent growth of non–Met-amplified cells within Met-amplified tumors. These findings establish the importance of MET in prostate cancer progression but reveal potential limitations in the clinical use of MET inhibitors in late-stage prostate cancer. Mol Cancer Ther; 14(1); 278–88. ©2014 AACR.
Fast Evaluation of Demagnetizing Field in Three Dimensional Micromagnetics Using Multipole Approximation (2001)

Computational micromagnetics in three dimensions is of increasing interest with the development of magnetostrictive sensors and actuators.In solving the Landau-Lifshitz-Gilbert (LLG) equation, the governing equation of magnetic dynamics for ferromagnetic materials, we need to evaluate the effective field.The effective field consists of several terms, among which the demagnetizing field is of long-range nature.Evaluating the demagnetizing field directly requires work of O(N 2 ) for a grid of N cells and thus it is the bottleneck in computational micromagnetics.A fast hierarchical algorithm using multipole approximation is developed to evaluate the demagnetizing field.We first construct a mesh hierarchy and divide the grid into boxes of different levels.The lowest level box is the whole grid while the highest level boxes are just cells.The approximate field contribution from the cells contained in a box is characterized by the box attributes, which are obtained via multipole approximation.The algorithm computes field contributions from remote cells using attributes of appropriate boxes containing those cells, and it computes contributions from adjacent cells directly.Numerical results have shown that the algorithm requires work of O(NlogN) and at the same time it achieves high accuracy.It makes micromagnetic simulation in three dimensions feasible.
Co-design of application software and NAND flash memory in solid-state drive for relational database storage system (2014)

A relational database management system (RDBMS) is designed based on NAND flash solid-state drive (SSD) for storage. By vertically integrating the storage engine (SE) and the flash translation layer (FTL), system performance is maximized and the internal SSD overhead is minimized. The proposed RDBMS SE utilizes physical information about the NAND flash memory which is supplied from the FTL. The query operation is also optimized for SSD. By these treatments, page-copy-less garbage collection is achieved and data fragmentation in the NAND flash memory is suppressed. As a result, RDBMS performance increases by 3.8 times, power consumption of SSD decreases by 46% and SSD life time is increased by 61%. The effectiveness of the proposed scheme increases with larger erase block sizes, which matches the future scaling trend of three-dimensional (3D-) NAND flash memories. The preferable row data size of the proposed scheme is below 500 byte for 16 kbyte page size.
Golgi tethering factor golgin-97 suppresses breast cancer cell invasiveness by modulating NF-κB activity (2018)

Golgin-97 is a tethering factor in the trans-Golgi network (TGN) and is crucial for vesicular trafficking and maintaining cell polarity. However, the significance of golgin-97 in human diseases such as cancer remains unclear. We searched for a potential role of golgin-97 in cancers using Kaplan-Meier Plotter ( http://kmplot.com ) and Oncomine ( www.oncomine.org ) datasets. Specific functions of golgin-97 in migration and invasion were examined in golgin-97-knockdown and golgin-97-overexpressing cells. cDNA microarray, pathway analysis and qPCR were used to identify gene profiles regulated by golgin-97. The role of golgin-97 in NF-κB signaling pathway was examined by using subcellular fractionation, luciferase reporter assay, western blot analysis and immunofluorescence assay (IFA). We found that low expression of golgin-97 correlated with poor overall survival of cancer patients and was associated with invasiveness in breast cancer cells. Golgin-97 knockdown promoted cell migration and invasion, whereas re-expression of golgin-97 restored the above phenotypes in breast cancer cells. Microarray and pathway analyses revealed that golgin-97 knockdown induced the expression of several invasion-promoting genes that were transcriptionally regulated by NF-κB p65. Mechanistically, golgin-97 knockdown significantly reduced IκBα protein levels and activated NF-κB, whereas neither IκBα levels nor NF-κB activity was changed in TGN46- or GCC185-knockdown cells. Conversely, golgin-97 overexpression suppressed NF-κB activity and restored the levels of IκBα in golgin-97-knockdown cells. Interestingly, the results of Golgi-disturbing agent treatment revealed that the loss of Golgi integrity was not involved in the NF-κB activation induced by golgin-97 knockdown. Moreover, both TGN-bound and cytosolic golgin-97 inhibited NF-κB activation, indicating that golgin-97 functions as an NF-κB suppressor regardless of its subcellular localization. Our results collectively demonstrate a novel and suppressive role of golgin-97 in cancer invasiveness. We also provide a new avenue for exploring the relationship between the TGN, golgin-97 and NF-κB signaling in tumor progression.
Adhesion and debonding kinetics of photovoltaic encapsulation in moist environments (2015)

Debonding of photovoltaic (PV) encapsulation in moist environments is frequently reported but presently not well understood or quantified. Temperature cycling, moisture, and mechanical loads often cause loss of encapsulation adhesion and interfacial debonding, initially facilitating back-reflectance and reduced electrical current, but ultimately leading to internal corrosion and loss of module functionality. To investigate the effects of temperature (T) and relative humidity (RH) on the kinetics of encapsulation debonding, we developed a mechanics-based technique to measure encapsulation debond energy and debond growth rates in a chamber of controlled environment. The debond energy decreased from 2.15 to 1.75 kJ m−2 in poly(ethylene-co-vinyl acetate) (EVA) and from 0.67 to 0.52 kJ m−2 in polyvinyl butyral when T increased from 25 to 50°C and 20 to 40°C, respectively. The debond growth rates of EVA increased up to 1000-fold with small increases of T (10°C) and RH (15%). To elucidate the mechanisms of environmental debonding, we developed a fracture-kinetics model, where the viscoelastic relaxation processes at the debonding-tip are used to predict debond growth. The model and techniques constitute the fundamental basis for developing accelerated aging tests and long-term reliability predictions for PV encapsulation. Copyright © 2015 John Wiley & Sons, Ltd.
Assessment of novel digital and smartphone goniometers for measurement of canine stifle joint angles (2016)

OBJECTIVE To evaluate accuracy and reliability of 3 novel goniometers for measurement of canine stifle joint angles and compare the results with those obtained with a universal goniometer (UG). SAMPLE 8 pelvic limbs from 4 canine cadavers. PROCEDURES Each limb was secured to a wooden platform at 3 arbitrarily selected fixed stifle joint angles. Goniometry was performed with 2 smartphone-based applications (novel goniometers A and B), a digital goniometer (novel goniometer C), and a UG; 3 evaluators performed measurements in triplicate for each angle with each device. Results were compared with stifle joint angle measurements on radiographs (used as a gold standard). Accuracy was determined by calculation of bias and total error, coefficients of variation were calculated to estimate reliability, and strength of linear association between radiographic and goniometer measurements was assessed by calculation of correlation coefficients. RESULTS Mean coefficient of variation was lowest for the UG (4.88%), followed by novel goniometers B (7.37%), A (7.57%), and C (12.71%). Correlation with radiographic measurements was highest for the UG (r = 0.97), followed by novel goniometers B (0.93), A (0.90), and C (0.78). Constant bias was present for all devices except novel goniometer B. The UG and novel goniometer A had positive constant bias; novel goniometer C had negative constant bias. Total error at 50° and 100° angles was > 5% for all devices. CONCLUSIONS AND CLINICAL RELEVANCE None of the devices accurately represented radiographically measured stifle joint angles. Additional veterinary studies are indicated prior to the use of novel goniometers in dogs.
Molecular Control Over the Interfacial Properties of High-T(c) Superconductors (2000)

Abstract : The surface coordination chemistry of the cuprate superconductor YBa2Cu3O sub 7 - gamma was extensively surveyed for the purpose of understanding the factors that govern the formation of robust, highly-ordered monolayers on these superconductor surfaces. Of the many functionalities investigated, long-chain primary amines formed the densest packed monolayer structure on both ceramic pellets and thin film substrates of YBa2Cu3O sub 7 - gamma Evidence for copper-amine interactions was obtained through SERS, and a computational model to accurately determine the local structure of the monolayer material was developed and implemented. Results of the computational study agree with experimentally determined properties of the materials. The computational studies also suggest that harmful water molecules are not able to penetrate the monolayer structure to damage the superconductor. This has been confirmed experimentally. Experimental evidence for two plausible mechanisms of monolayer formation was obtained in these studies. In addition, all surface modifications examined in this work did not damage the inherent superconducting properties of the bulk material.
Exosomal MEK1 delays tumor growth by promoting anti-tumor immunity (2017)

Abstract Exosomes mediate intercellular communication and regulation in many processes, including cancer-immune cell interactions. Exosomes are small (~100 nm) membrane vesicles that arise from the late endosomal pathway and contain bioactive molecules that are transferred to and affect the function of target cells. Tumor-derived exosomes are important regulators of anti-tumor immunity and have been shown to exert stimulatory and inhibitory effects on immune cells, depending on the experimental setting. Using a proteomic approach, we found that exosomes derived from tumors that undergo immune rejection ("regressors") contain different proteins than exosomes from progressively growing tumors ("progressors"). Specifically, the signaling molecule MAP2K1 ("MEK1") is highly enriched in regressor compared to progressor exosomes, leading us to hypothesize that exosomal MEK1 stimulates anti-tumor immunity and inhibits tumor progression. We found that forced expression of MEK1 in progressor exosomes delays tumor growth and increases anti-tumor immune cell infiltration, and that MEK1-hi exosomes are sufficient to delay tumor growth, but MEK1-low exosomes are not. Moreover, we found that MEK1 protein can be physically transferred from tumor cells to macrophages via exosomes, and that MEK1-hi exosomes induce pro-inflammatory cytokine production in macrophages, but MEK1-low exosomes do not. We propose that tumor-derived MEK1 is transferred to macrophages via exosomes, which enhances their anti-tumoricidal effector function and delays tumor growth. This cell extrinsic, anti-tumor activity of MEK1 contrasts with the known oncogenic properties of MEK1 and could limit the efficacy of MEK1 inhibitors currently in clinical trials.
New Cathode and Electrolytes Strategies to Enable High-Energy Li-S Batteries (2021)

Lithium–sulfur batteries are attractive alternatives to lithium-ion batteries because of their high theoretical specific energy and natural abundance of sulfur. However, the polysulfides shuttle and the Li metal dendrite and corrosion significantly limit their cycle life. Moreover, the poor electronic conductivity of sulfur results in low areal sulfur loading and poor utilization, leading to low overall specific energy. In the past years, we have developed several new strategies to mitigate these probelms, including: (1) Se doing because of much higher electronic conductivity of Se than Sulfur;[ref 1] (2) new electrolytes to directly bypass polysulfides formation and enable reversible Li stripping/plating;[ref 2 and 3]; (3) rational cathode design to boost sulfur reaction kinetics and suppress polysulfides shuttle and Li corrosion (ref 4 and 5). Through these approaches, we have significantly improve the cycle life and specific energ of Li-S batteries in both coin-cells and pouch-cells. Ref: [1] Xu, G. L .; Ma, T.; Sun, C. J.; Luo, C.; Cheng, L.; Ren, Y.; Heald, S. M.; Wang, C.; Curtiss, L.; Wen, J.; Miller, D. J.; Li, T.; Zuo, X.; Petkov, V.; Chen, Z.*; Amine, K.*, Insight into the Capacity Fading Mechanism of Amorphous Se2S5 Confined in Micro/Mesoporous Carbon Matrix in Ether-Based Electrolytes. Nano Lett., 2016 , 16, 2663-2673. [2] Xu, G. L. ; Sun, H.; Luo, C.; Estevez, L.; Zhuang, M. H.; Gao, H.; Amine, R.; Wang, H.; Zhang, X.; Sun, C. J.; Liu, Y. Z.; Ren, Y.; Heald, S.; Wang, C. S.; Chen, Z.*; Amine, K.*, Solid-State Lithium/Selenium-Sulfur Chemistry Enabled via a Robust Solid-Electrolyte Interphase. Adv. Energy Mater., 2018, 1802235. [3] Amine, R.; Liu, J.; Acznik, I.; Sheng, T.; Lota, K.; Sun, H.; Sun, C. J.; Fic, K.; Zuo, X.; Ren, Y.; EI-Hady, D. A.; Alshitari, W.; Al-Bogami, A. S.; Chen, Z.; Amine, K. (*) and Xu, G. L. (*). Regulating the Hidden Solvation-Ion-Exchange in Concentrated Electrolytes for Stable and Safe Lithium Metal Batteries. Adv. Energy Mater., 2020 , 2000901. [4] Zhao, C.; Xu, G. L.(*) ; Zhao, T. (*); Amine, K.(*). Beyond Polysulfides Shuttle and Li Dendrite Formation: Addressing the Sluggish S Redox Kinetics for Practical High Energy Li-S batteries. Angew. Chem. Int. Ed. 2020 , 17634-17640. [5] Zhao, C.; Xu, G. L.(*) ; Yu, Z.; Zhang, L.; Hwang, I.; Mo, Y.-X.; Ren, Y.; Cheng, L.; Sun, C. -J.; Ren, Y.; Zuo, X.; Li, J.-T.; Sun, S.-G.; Amine, K.(*) and Zhao, T.(*). A high-energy and long-cycling lithium-sulfur pouch cell via a macroporous catalytic cathode with double-end binding sites. Nature Nanotechnology , 2020 , https:// doi .org/ 1 0 . 1 0 3 8 / s 4 1 5 6 5 - 0 2 0 - 0 0 797-w .
An autonomous untethered fast soft robotic insect driven by low-voltage dielectric elastomer actuators (2019)

Insects are a constant source of inspiration for roboticists. Their compliant bodies allow them to squeeze through small openings and be highly resilient to impacts. However, making subgram autonomous soft robots untethered and capable of responding intelligently to the environment is a long-standing challenge. One obstacle is the low power density of soft actuators, leading to small robots unable to carry their sense and control electronics and a power supply. Dielectric elastomer actuators (DEAs), a class of electrostatic electroactive polymers, allow for kilohertz operation with high power density but require typically several kilovolts to reach full strain. The mass of kilovolt supplies has limited DEA robot speed and performance. In this work, we report low-voltage stacked DEAs (LVSDEAs) with an operating voltage below 450 volts and used them to propel an insect-sized (40 millimeters long) soft untethered and autonomous legged robot. The DEAnsect body, with three LVSDEAs to drive its three legs, weighs 190 milligrams and can carry a 950-milligram payload (five times its body weight). The unloaded DEAnsect moves at 30 millimeters/second and is very robust by virtue of its compliance. The sub-500-volt operation voltage enabled us to develop 780-milligram drive electronics, including optical sensors, a microcontroller, and a battery, for two channels to output 450 volts with frequencies up to 1 kilohertz. By integrating this flexible printed circuit board with the DEAnsect, we developed a subgram robot capable of autonomous navigation, independently following printed paths. This work paves the way for new generations of resilient soft and fast untethered robots.
A Scalable Bayesian Inference Accelerator for Unsupervised Learning (2020)

This article consists only of a collection of slides from the author's conference presentation.
CHROMOSOME 9P DELETIONS IN SMALL CLEAR CELL RENAL CARCINOMA TUMORS (<4 CM) ARE ASSOCIATED WITH SYNCHRONOUS AND METACHRONOUS METASTATIC DISEASE (2009)

You have accessJournal of Urology1 Apr 2009CHROMOSOME 9P DELETIONS IN SMALL CLEAR CELL RENAL CARCINOMA TUMORS (<4 CM) ARE ASSOCIATED WITH SYNCHRONOUS AND METACHRONOUS METASTATIC DISEASE Jeffrey C La Rochelle, Aditi Dastane, Nagesh Rao, Tobias Klatte, Brian Shuch, Michela de Martino, Nazy Zomorodian, Fairooz Kabbinavar, Arie S Belldegrun, and Allan J Pantuck Jeffrey C La RochelleJeffrey C La Rochelle More articles by this author , Aditi DastaneAditi Dastane More articles by this author , Nagesh RaoNagesh Rao More articles by this author , Tobias KlatteTobias Klatte More articles by this author , Brian ShuchBrian Shuch More articles by this author , Michela de MartinoMichela de Martino More articles by this author , Nazy ZomorodianNazy Zomorodian More articles by this author , Fairooz KabbinavarFairooz Kabbinavar More articles by this author , Arie S BelldegrunArie S Belldegrun More articles by this author , and Allan J PantuckAllan J Pantuck More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)60609-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "CHROMOSOME 9P DELETIONS IN SMALL CLEAR CELL RENAL CARCINOMA TUMORS (<4 CM) ARE ASSOCIATED WITH SYNCHRONOUS AND METACHRONOUS METASTATIC DISEASE." The Journal of Urology, 181(4S), p. 212 © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 4SApril 2009Page: 212 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetricsAuthor Information Jeffrey C La Rochelle More articles by this author Aditi Dastane More articles by this author Nagesh Rao More articles by this author Tobias Klatte More articles by this author Brian Shuch More articles by this author Michela de Martino More articles by this author Nazy Zomorodian More articles by this author Fairooz Kabbinavar More articles by this author Arie S Belldegrun More articles by this author Allan J Pantuck More articles by this author Expand All Advertisement PDF downloadLoading ...