gebhart/patrepeval huggingface dataset:
Effect of Telaprevir on the Pharmacokinetics of Buprenorphine in Volunteers on Stable Buprenorphine/Naloxone Maintenance Therapy (2012)

This was an open-label, single-sequence trial in hepatitis C virus-negative volunteers on stable, individualized, buprenorphine maintenance therapy. Telaprevir at 750 mg every 8 h was coadministered with buprenorphine/naloxone (4:1 ratio as sublingual tablets) for 7 days with food. Pharmacokinetic profiles of buprenorphine, norbuprenorphine, and naloxone were measured over the 24-hour dosing interval on day -1 (buprenorphine/naloxone alone, reference) and day 7 of telaprevir coadministration (test). Geometric least-squares mean ratios and associated 90% confidence intervals of treatment ratios (test/reference) were calculated using log-transformed pharmacokinetic parameters. Opioid withdrawal symptoms were evaluated throughout the study (via questionnaires and pupillometry). Pharmacokinetic data were available for 14 and 13 volunteers on day -1 and day 7, respectively. The area under the concentration-time curve (AUC) for buprenorphine was unchanged and the maximum concentration of drug in serum (C(max)) for buprenorphine, C(max) and AUC for norbuprenorphine, and C(max) naxolone were modestly decreased during coadministration with telaprevir. Geometric least-squares mean ratios (90% confidence intervals) for buprenorphine were 0.80 (0.69, 0.93) for the C(max) and 0.96 (0.84, 1.10) for the AUC from 0 to 24 h (AUC(0-24)); for norbuprenorphine, values were 0.85 (0.66, 1.09) for C(max) and 0.91 (0.71, 1.16) for AUC(0-24); for naloxone, the C(max) was 0.84 (0.62, 1.13). Coadministration of telaprevir did not increase withdrawal symptom frequency, and there were no serious adverse events reported during or after completion of telaprevir coadministration. Results suggest dose adjustment may not be necessary when telaprevir and buprenorphine/naloxone are coadministered.
Visual Servoing in Autoencoder Latent Space: Supplementary material (2021)

This document provides additional information about [1], describing further experiments with Autoencoderbased visual servoing (AEVS), a method for visual servoing in the latent space of an autoencoder. Multiple experiments are described, both in a simulated environment and on a real robot. In this document, we first evaluate the impact of the network specification and dataset sizes on the visual servoing results. Then we conduct experiments to ascertain the applicability and transferability of the method to complex scenes.
Outgassing characteristics of low molecular weight resist for EUVL (2004)

Extreme ultraviolet (EUV) lithogmphy requires a vacuum environment for exposure. Therefore, it is critical to understand the outgassing hydrocarbon ion species of the photoresist. Any contamination which due to the hydrocarbons reduces the reflectivities of the mask and the imaging mirror and the lithographic performance. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-3)</sup> In this paper, we discuss the outgassing characterigics of new concept resist system, which is based on amorphous low molecular weight polyphenols. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4)</sup> The resist which consists of 4,4' -methylenebis[2-[di(2-methyl-4-hydroxy-5-cyclohexylphenyl)]methyl] phenol (3M6C-MBSA) has already shown excellent lithographic performance, surface roughness and etch selectivity as compared to Poly-hydroxystyrene (PHOST) based resist under eIectron beam exposure.
Hyperglycemia-induced insulin resistance in diabetic dyslipidemic Yucatan swine. (2003)

Hyperglycemia, dyslipidemia, and associated insulin resistance are hallmarks of diabetes mellitus. Purposes of the study reported here were to develop practical methods for assessment of in vivo insulin sensitivity and determine contributions of hyperglycemia and dyslipidemia to insulin resistance in the porcine model of alloxan-induced diabetes mellitus and dyslipidemia. Male Yucatan swine groups were treated for 20 weeks: control (C), high fat-fed (2% cholesterol) hyperlipidemic (H), alloxan-induced diabetic normolipidemic (D), diabetic high fat-fed (diabetic dyslipidemic, DD), and diabetic dyslipidemic treated with the lipid-lowering agent atorvastatin (DDA). Plasma cholesterol concentration increased sixfold in animals of groups H, DD, and DDA, whereas triglyceride concentration increased threefold in animals of group DD only. Diabetics had decreases in glucose tolerance and pancreatic immunostaining for insulin. Use of the gold standard hyperinsulinemic euglycemic clamp procedure indicated that maximal insulin-stimulated glucose uptake was similar to that in humans, but this method was not practical for use in pigs. Instead, a more convenient and valid insulin sensitivity test involving suppression of insulin secretion with somatostatin and a single insulin injection was used. Insulin sensitivity was greatly impaired by anesthesia with isoflurane, but was not affected by use of the anxiolytic agent diazepam. Insulin sensitivity decreased by 75% in diabetics (groups D, DD, DDA), compared with animals of groups C and H, and was inversely related to fasting blood glucose concentration (r = -0.72). Insulin treatment to restore blood glucose values of diabetics (> 250 mg/dl) to near control values (< 100 mg/dl) promptly restored insulin sensitivity to control values. We conclude that hyperglycemia is a major cause of insulin resistance in the porcine model of alloxan-induced diabetes mellitus and dyslipidemia.
Information Harvesting for Far-Field Wireless Power Transfer (2021)

Considering ubiquitous connectivity and advanced information processing capability, huge amount of low-power IoT devices are deployed nowadays and the maintenance of those devices which includes firmware/software updates and recharging the units has become a bottleneck for IoT systems. For addressing limited battery constraints, wireless power transfer is a promising approach such that it does not require any physical link between energy harvester and power transfer. Furthermore, combining wireless power transfer with information transmission has become more appealing. In the systems that apply radio signals the wireless power transfer has become a popular trend to harvest RF-radiated energy from received information signal in IoT devices. For those systems, design frameworks mainly deal with the trade-off between information capacity and energy harvesting efficiency. Therein various signaling design frameworks have been proposed for different system preferences between power and information. In addition to this, protecting the information part from potential eavesdropping activity in a service area introduces security considerations for those systems. In this paper, we propose a novel concept, Information Harvesting, for wireless power transfer systems. It introduces a novel protocol design from opposite perspective compared to the existing studies. Particularly, Information Harvesting aims to transmit information through existing wireless power transfer mechanism without interfering/interrupting power transfer.
An FDG-PET/CT digital reference object for testing ROI and SUV calculations (2012)

607 Objectives There is a need for an objective verification of the calculation of PET image standardized uptake values (SUVs) from region of interest (ROI) analysis tools provided by scanner manufacturers and third-party analysis systems. As part of the Quantitative Imaging Biomarker Alliance (QIBA) initiative, we are developing tools to test or verify the quantitative accuracy of PET images and image analysis tools. Methods We have developed a Digital Reference Object (DRO) that mimics PET and CT images, but with known truth, to allow testing of ROI-based SUV calculations. The DRO consists of two 9stacks9 of DICOM images, one for PET and one for CT. The DICOM images are based on a synthetic multi-bed PET/CT acquisition of a modified version of the NEMA/MITA NU-2 image quality phantom. Results The FDG-PET/CT DRO has been constructed with features designed to test ROI based metrics, including SUV calculation, SUVmax, SUVmean, pixel std. dev., negative values, ROI pixel inclusion policies, PET-CT alignment, and other features of PET/CT image analysis software packages. The DRO has been tested using the dciodvfy DICOM validation tool, and read in successfully of several different PET/CT image analysis platforms. Conclusions In cases where accurate SUVs from PET images are important, e.g. assessing response to therapy, verifying the accuracy of the PET/CT image analysis is essential, but has not been done to date in a verifiable manner. The FDG-PET/CT DRO provides a means to perform this verification. Research Support Supported by a RSNA/QIBA grant
Two-photon spectroscopy of the F1∏g and f3∏g states of molecular fluorine (1988)

In the interest of developing a sensitive detection technique for molecular fluorine, we attempted two-photon-excited ionization detection of the F 1 ∏ g state. The frequency-doubled output of a Nd:YAG-pumped dye laser was Raman shifted and the third anti-Stokes line selected with a Pellin-Broca prism. This light at around 207 nm was focused into a cell containing ~120 Torr of 10% F 2 in He gas mixture. The ions produced were detected with a pair of electrodes biased to 500 V and amplified with a charge amplifier. High-resolution spectra of both the F 1 ∏ g state and the near-lying f 3 ∏ g state were obtained. The f 3 ∏ g state, a spin-forbidden transition from the ground state, is of interest because it is thought to be the upper level of the F 2 laser transition at 157 nm, possibly the spectrally brightest source in the VUV today. In a recent theoretical investigation 1 of the f 3 ∏ g state in fluorine it was found that the 157-nm laser transition could not be conclusively assigned. We are currently attempting to observe VUV fluorescence from the two-photon excited f 3 ∏ g state. If this experiment is successful, it would definitively assign the upper level of the F 2 laser, allow further spectroscopy measurements of this important level, and demonstrate a fluorescence-based detection technique for molecular fluorine.
High Plasma Sphingosine 1-phosphate Levels Predict Osteoporotic Fractures in Postmenopausal Women: The Center of Excellence for Osteoporosis Research Study (2018)

The associations between plasma S1P levels and fracture risk were independent of BMD and other confounders. These findings demonstrate that high plasma S1P level at baseline and at years 1 to 5 is a strong and independent risk factor for future [ORFs] among postmenopausal women and could be a useful biomarker for fracture risk assessment in this population.
Radar tasks scheduling for a multifunction phased array radar with hard time constraint and priority (2014)

This paper presents the radar tasks scheduling problem for a set of tasks called Hard Time Constraint tasks which cannot delay their processing by more than a positive constant α and for a set of tasks called Soft Time Constraint tasks which can be processed at any time. For this problem, we present a method composed of an algorithm which sequence HTC tasks; composed of an heuristic which sequence STC tasks and composed of a selection rule in order to determine which task has to be scheduled between the first task of both sequences.
Rate-Splitting Multiple Access for Short-Packet Uplink Communications: A Finite Blocklength Analysis (2022)

In this letter, we investigate the performance of Rate-Splitting Multiple Access (RSMA) for an uplink communication system with finite blocklegnth (FBL). Considering a two-user Single-Input Single-Output (SISO) Multiple Access Channel (MAC), we study the impact of blocklength and target rate on the throughput and error probability performance of RSMA where one user message is split. We demonstrate that RSMA can outperform Non-Orthogonal Multiple Access (NOMA) in terms of throughput and error probability performance.
Silicon Millimeter-Wave RadioCircuits at60-100 GHz(invited) (2007)

Thispaperreviews silicon millimeter-wave radiocircuits operating between60 and 100GHz. Transmitter andreceiver chips operating inthe60-GHzISM bandarehighlighted, wherethepackaged chipset hasshown datarates ashighas2Gb/sover5m forawireless high- definition video link. Inaddition, a60GHzPAwith23dBm output powerandaclass-E 60GHzPAwith>20%peakPAE arereviewed. Finally, 77and94GHzdownconverters are presented asa basisforanoutlook totheperformance achievable atthese higher frequency bands. IndexTerms - 60 GHz,millimeter wavebipolar integrated circuits, SiGe, V band.
Manganese [correction of Magnesium] superoxide dismutase (MnSOD) plasmid/liposome pulmonary radioprotective gene therapy: Modulation of irradiation-induced mRNA for IL-I, TNF-alpha, and TGF-beta correlates with delay of organizing alveolitis/fibrosis (1999)

Radiation pneumonitis remains a critical dose-limiting toxicity of total body irradiation (TBI) for use in bone marrow transplantation. The acute and chronic phases of radiation damage in the mouse lung have been shown to correlate with mouse strain genotype and are dependent on fraction size, total dose, and total lung volume. Our prior studies demonstrated effective prevention of irradiation-induced lung damage and improved survival in C57BL/6J mice by MnSOD plasmid/liposome gene therapy. In the present studies, we investigated the kinetics of irradiation-induced upregulation of mRNA for acute phase cytokines interleukin (IL)-1 and tumor necrosis factor (TNF)-alpha, and fibrosis-associated transforming growth factor (TGF)-beta and isoforms (TGF-beta1, TGF-beta2 and TGF-beta3) in 2000 cGy whole-lung irradiated C57BL/6J mice, a strain known to develop dose and volume-dependent organizing alveolitis/fibrosis. The results demonstrate increase in mRNA for IL-1 between days 1 and 14 after irradiation with return to baseline levels out to 120 days. TNF-alpha mRNA levels were not initially elevated but increased between 80 and 100 days and then decreased by 120 days. The mRNA levels for TGF-beta1 demonstrated an initial increase within the first 14 days after total lung irradiation with a decrease to baseline levels out to 100 days. Then, in striking contrast to the other two cytokines, an increase in TGF-beta2 mRNA occurred at around 120 days and correlated with the detection of organizing alveolitis/radiation fibrosis and mortality. These results are consistent with a two-phase mechanism in the molecular pathology of irradiation lung injury, in which IL-1 cytokine mRNA levels correlated with the acute pneumonitis phase and delayed elevation of TNF-alpha (80-100 days), TGF-beta1 (100 days), and TGF-beta2 (120 days) were associated with the fibrosis phase. Insight into the cell-specific and tissue-specific molecular mechanisms of ionizing irradiation induction of mRNA for pulmonary cytokines may provide new strategies for treatment of radiation pneumonitis in TBI patients.
Materials Science and Engineering (2017)

a b s t r a c t The rapidly solidified AlCr4.7Fe1.1Si0.3 (at.%) alloy produced at large scale by direct extrusion of gas atomised powders was investigated. Hot-extrusion yielded sound compacts and did not create any major structural changes compared to the as-atomised state. Microstructural characterisation of the as-extruded material revealed submicron scale -Al grains with an embedded Al7Cr crystalline phase and traces of a nano-scale quasicrystalline Al84.6Cr15.4 phase. The long-term thermal stability up to 300 ◦C of compacts was proven. The thermal stability of compacts was accompanied by high mechanical prop- erties, especially high strength and Young's modulus, and creep performance up to 300 ◦C. The same material was prepared by laboratory scale extrusion of cryo-chopped melt-spun ribbons as a reference material. No major differences in the structure or properties of the industrially prepared material were observed compared to the reference material.
Symmetric Halogen Bonding Is Preferred in Solution (2012)

Halogen bonding is a recently rediscovered secondary interaction that shows potential to become a complementary molecular tool to hydrogen bonding in rational drug design and in material sciences. Whereas hydrogen bond symmetry has been the subject of systematic studies for decades, the understanding of the analogous three-center halogen bonds is yet in its infancy. The isotopic perturbation of equilibrium (IPE) technique with (13)C NMR detection was applied to regioselectively deuterated pyridine complexes to investigate the symmetry of [N-I-N](+) and [N-Br-N](+) halogen bonding in solution. Preference for a symmetric arrangement was observed for both a freely adjustable and for a conformationally restricted [N-X-N](+) model system, as also confirmed by computation on the DFT level. A closely attached counterion is shown to be compatible with the preferred symmetric arrangement. The experimental observations and computational predictions reveal a high energetic gain upon formation of symmetric, three-center four-electron halogen bonding. Whereas hydrogen bonds are generally asymmetric in solution and symmetric in the crystalline state, the analogous bromine and iodine centered halogen bonds prefer symmetric arrangement in solution.
Supplementary Table 3 from p21-Activated Kinase 1 Is Required for Efficient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model (2023)

&lt;p&gt;PDF file - 58K, Specificity of Pak inhibitors&lt;/p&gt;
Experimental results on interference mitigation with a 19 element array feed (2007)

This paper presents experimental results for adaptive spatial filtering of radio frequency interference (RFI) using a 19 element, L-band focal plane array feed on a small (3 meter) reflector. Successful cancellation was observed for simulated stationary and moving RFI sources. Signal and noise response fluctuations (pattern rumble) due to beamformer adaptation was observed to be significantly larger for a moving interferer than for a stationary interferer, which points to the need for specialized signal processing to suppress pattern rumble in the presence of nonstationary RFI. (5 pages)
ChemInform Abstract: Mono N‐Arylation of Piperazine(III): Metal‐Catalyzed N‐Arylation and Its Application to the Novel Preparations of the Antifungal Posaconazole and Its Advanced Intermediate. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Rotational Alignment of the Knee is Different in Osteological Specimens with and without a Large Cam Deformity of the Proximal Femur (2017)

Specimens with femoral head-neck alpha angle >60° demonstrated greater external rotation of the distal femur and a more internally-rotated tibial tubercle compared to specimens with an alpha angle <45°. Differences in anatomic characteristics of the knee may play a role in the development of patellofemoral pain in patients with a large cam deformity.
330 GHz / 500 MHz Dynamic Nuclear Polarization-NMR spectrometer (2016)

We describe the implementation of a 330 GHz gyrotron and microwave transmission line system for Dynamic Nuclear Polarization - NMR experiments performed at <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> H frequencies of 500 MHz. Overall microwave transmission efficiency of 72% was achieved by careful alignment of the corrugated waveguides. Initial DNP signal enhancement of 120 was observed.
Quaternary Carbon Stereogenic Centers through Copper‐Catalyzed Enantioselective Allylic Substitutions with Readily Accessible Aryl‐ or Heteroaryllithium Reagents and Aluminum Chlorides (2010)

Jetzt auch mit Aryl: Die erste effiziente katalytische und enantioselektive Methode für allylische Substitutionen, die quartäre stereogene Kohlenstoffzentren durch Addition von Aryl- oder Heteroarylmetallen erzeugen, wird beschrieben (siehe Schema). Die hoch orts- und enantioselektiven Prozesse gehen von leicht verfügbaren Organolithiumreagentien aus.
Targeting Urothelium: Ex Vivo Assay Standardization and Selection of Internalizing Ligands (2003)

We introduce a strategy for screening combinatorial peptide libraries on bladder mucosa, a standard model for ex vivo intact urothelium binding assays and a panel of urothelium binding peptides that may be suitable for translation into targeted intravesical therapy applications.
Structural basis for the dual RNA-recognition modes of human Tra2-β RRM (2010)

Human Transformer2-β (hTra2-β) is an important member of the serine/arginine-rich protein family, and contains one RNA recognition motif (RRM). It controls the alternative splicing of several pre-mRNAs, including those of the calcitonin/calcitonin gene-related peptide (CGRP), the survival motor neuron 1 (SMN1) protein and the tau protein. Accordingly, the RRM of hTra2-β specifically binds to two types of RNA sequences [the CAA and (GAA)(2) sequences]. We determined the solution structure of the hTra2-β RRM (spanning residues Asn110-Thr201), which not only has a canonical RRM fold, but also an unusual alignment of the aromatic amino acids on the β-sheet surface. We then solved the complex structure of the hTra2-β RRM with the (GAA)(2) sequence, and found that the AGAA tetra-nucleotide was specifically recognized through hydrogen-bond formation with several amino acids on the N- and C-terminal extensions, as well as stacking interactions mediated by the unusually aligned aromatic rings on the β-sheet surface. Further NMR experiments revealed that the hTra2-β RRM recognizes the CAA sequence when it is integrated in the stem-loop structure. This study indicates that the hTra2-β RRM recognizes two types of RNA sequences in different RNA binding modes.
A novel approach for selecting combination clinical markers of pathology applied to a large retrospective cohort of surgically resected pancreatic cysts (2016)

Our approach identified combinatorial markers for pancreatic cyst classification that had improved performance relative to the individual features they comprise. In principle, this approach can be applied to any clinical dataset comprising dichotomous, categorical, and continuous-valued parameters.
NREM and REM: cognitive and energetic gains in thalamo-cortical sleeping and awake spiking model (2022)

Sleep is essential for learning and cognition, but the mechanisms by which it stabilizes learning, supports creativity, and manages the energy consumption of networks engaged in post-sleep task have not been yet modelled. During sleep, the brain cycles between non-rapid eye movement (NREM), a mainly unconscious state characterized by collective oscillations, and rapid eye movement (REM), associated with the integrated experience of dreaming. We propose a biologically grounded two-area thalamo-cortical plastic spiking neural network model and investigate the role of NREM - REM cycles on its awake performance. We demonstrate that sleep has a positive effect on energy consumption and cognitive performance during the post-sleep awake classification task of handwritten digits. NREM and REM simulated dynamics modify the synaptic structure into a sharper representation of training experiences. Sleep-induced synaptic modifications reduce firing rates and synaptic activity without reducing cognitive performance. Also, it creates novel multi-area associations. The model leverages the apical amplification, isolation and drive experimentally grounded principles and the combination of contextual and perceptual information. In summary, the main novelty is the proposal of a multi-area plastic model that also expresses REM and integrates information during a plastic dream-like state, with cognitive and energetic benefits during post-sleep awake classification.