gebhart/patrepeval huggingface dataset:
Abstract P3-10-20: Targeting the tyrosine phosphatase SHP2 is efficacious against HER2-positive breast cancer (2020)

Abstract Accumulating evidence suggests that the Src homology phosphotyrosyl phosphatase 2 (SHP2) is a bona fide oncogene. These conclusions are primarily based on the positive role of SHP2 in receptor tyrosine kinase (RTK) signaling in multiple systems. Because overexpression of the human epidermal growth factor receptor 2 (HER2) is one of the primary causes of BC, we investigated the potential of SHP2 targeting in this subtype of BC. We have used our recently patented SHP2 inhibitor called WGMDY (US 9,932,288) for targeting SHP2 under cell culture and in vivo conditions. We have also used the recently reported allosteric SHP2 inhibitor called SHP099 particularly in the cell culture studies. We found that HER2-positive BC cells are highly sensitive to SHP2 inhibition with WGMDY as determined by loss of viability in 2D, transformation in soft agar, and cancer stem cell properties in suspension cultures. Similar results were obtained with SHP099 albeit at a reduced rate. Analysis of protein and RNA extracts showed inhibition of the Ras-ERK and the PI3K-Akt signaling pathways by WGMDY, but SHP099 tend to activate Akt signaling. In addition, WGMDY blocked overexpression of the HER2 protein in HER2-positive BC cells. As such, we focused on WGMDY for the in vivo efficacy studies. The results showed that WGMDY induces regression of preformed tumors in a concentration dependent manner. Histopathology analyses of tumors showed induction of necrosis in treated samples. Hence, WGMDY has a promising anti-cancer effects in HER2-positive BC. Citation Format: Yehenew Agazie, Zachary Hartman. Targeting the tyrosine phosphatase SHP2 is efficacious against HER2-positive breast cancer [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P3-10-20.
27.7 A 0.05mm<sup>2</sup> 1V capacitance-to-digital converter based on period modulation (2015)

This paper presents a digitally assisted period modulation (PM)-based capacitance-to-digital converter (CDC) that is >9× smaller than prior CDCs with >10b resolution [1-4], and improves the energy efficiency by >10× compared to previous PM-based CDCs [1]. This is achieved with the help of a piece-wise charge transfer technique that eliminates the need for a large on-chip integration capacitor, a dual-integration-capacitor scheme that reduces the front-end noise contribution, a sampled-biasing technique that reduces the noise of the integration current, and a current-efficient inverter-based design.
Arbitrary and Independent Polarization Control In Situ via a Single Metasurface (2018)

Abstract A single metasurface is demonstrated with powerful manipulating capability to arbitrarily and independently tune the phase profiles of orthogonal polarization states using subwavelength tunable cross‐shaped element (TCE) arrays. Here, the arbitrary control of the phase profiles must be distinguished from the semiarbitrary phase control using multiple predesigned metasurfaces with one‐to‐one functionality. The decoupled tuning of phase profiles for orthogonal polarization states bestows the metasurface with additional degree of freedom to manipulate the electromagnetic wave for multifunctionality. As a proof of concept, a tunable polarization beam splitter, a dynamic beam steering component, and a quarter waveplate are demonstrated using one single metasurface. This metasurface has promising applications on versatile and function‐switchable photonic components, such as polarization optical devices, compact functional devices, communication systems, and wave controlling devices, to name just a few.
Human Leukocyte Interferon in the Treatment and Prophylaxis of Acute Hemorrhagic Conjunctivitis (1984)

Journal Article Human Leukocyte Interferon in the Treatment and Prophylaxis of Acute Hemorrhagic Conjunctivitis Get access S. K. Stansfield, S. K. Stansfield Search for other works by this author on: Oxford Academic PubMed Google Scholar W. de la Pena, W. de la Pena Search for other works by this author on: Oxford Academic PubMed Google Scholar S. Koenig, S. Koenig Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Espaillat Cabral, A. Espaillat Cabral Search for other works by this author on: Oxford Academic PubMed Google Scholar H. Kaufman, H. Kaufman Search for other works by this author on: Oxford Academic PubMed Google Scholar M. H. Hatch, M. H. Hatch Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Hierholzer, J. Hierholzer Search for other works by this author on: Oxford Academic PubMed Google Scholar L. B. Schonberger L. B. Schonberger Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 149, Issue 5, May 1984, Pages 822–823, https://doi.org/10.1093/infdis/149.5.822 Published: 01 May 1984
Efficient program transformations for resilient parallel computation via randomization (preliminary version) (1992)

In this paper, we address the problem of automatically transforming arbitrary programs written for an ideal parallel machine to run on a completely asynchronous machine. We present a transformation which can be applied to an ideal program such that the resulting program's execution on an asynchronous machine is work and space efficient, relative to the ideal program from which it is derived. Above all, the transformation will guarantee that the ideal program will execute in a continually progressive manner on the asynchronous machine; these instructions are not universal. Furthermore, the individual processors can get delayed for arbitrary amounts of time while executing any instruction. In contrast, previous work relied either on the asynchronous machine having universal read-modify-write instructions as primitives, or on limited asynchrony by restricting the relative speeds of the processors.
Photochemical Transformation of Free Chlorine Induced by Triplet State Dissolved Organic Matter (2023)

Photolysis of free chlorine is an increasingly recognized approach for effectively inactivating microorganisms and eliminating trace organic contaminants. However, the impact of dissolved organic matter (DOM), which is ubiquitous in engineered water systems, on free chlorine photolysis is not yet well understood. In this study, triplet state DOM (<sup>3</sup>DOM*) was found to cause the decay of free chlorine for the first time. By using laser flash photolysis, the scavenging rate constants of triplet state model photosensitizers by free chlorine at pH 7.0 were determined to be in the range of (0.26-3.33) × 10<sup>9</sup> M<sup>-1</sup> s<sup>-1</sup>. <sup>3</sup>DOM*, acting as a reductant, reacted with free chlorine at an estimated reaction rate constant of 1.22(±0.22) × 10<sup>9</sup> M<sup>-1</sup> s<sup>-1</sup> at pH 7.0. This study revealed an overlooked pathway of free chlorine decay during UV irradiation in the presence of DOM. Besides the DOM's light screening ability and scavenging of radicals or free chlorine, <sup>3</sup>DOM* played an important role in the decay of free chlorine. This reaction pathway accounted for a significant proportion of the decay of free chlorine, ranging from 23 to 45%, even when DOM concentrations were below 3 mg<sub>C</sub> L<sup>-1</sup> and a free chlorine dose of 70 μM was present during UV irradiation at 254 nm. The generation of HO<sup>•</sup> and Cl<sup>•</sup> from the oxidation of <sup>3</sup>DOM* by free chlorine was confirmed by electron paramagnetic resonance and quantified by chemical probes. By inputting the newly observed pathway in the kinetics model, the decay of free chlorine in UV<sub>254</sub>-irradiated DOM solution can be well predicted.
A comprehensive dynamic processor allocation scheme for multiprogrammed multiprocessor systems (2002)

Parallel execution of application programs on a multiprocessor system may lead to performance degradation if the workload of a parallel region is not large enough to amortize the overheads associated with the parallel execution. Furthermore, if too many processes are running on the system in a multiprogrammed environment, the performance of the parallel application may degrade due to resource contention. We propose a comprehensive dynamic processor allocation scheme that takes both program behavior and system load into consideration when dynamically allocating processors. We implemented this mechanism in the Java run-time system on Solaris to dynamically control the execution of parallel Java application programs. Performance results show the effectiveness of this scheme in dynamically adapting to the current execution environment and that it outperforms a conventional time-shared system.
High-resolution spectroscopy of the /sup 39/K transitions at 770 nm and /sup 13/C/sub 2/H/sub 2/ saturated lines by a solid-state laser at 1.54 μm: toward an accurate frequency standard in the optical communication band (2002)

A novel and compact Er-Yb:glass laser was developed with single-frequency output power >10 mW in a wavelength range from 1531 to 1547 nm. The laser output was efficiently frequency doubled at 770.1 nm in a single-pass periodically poled lithium niobate waveguide and a second harmonic power in excess of 15 /spl mu/W was achieved, with an internal conversion efficiency of /spl sim/220% W/sup -1/. This frequency-doubled beam was used for high-resolution saturated spectroscopy of the /sup 39/K 4S/sub 1/2 /-4P/sub 1/2 / absorption line. The best resolved crossover peak showed 16% line contrast and 10-MHz linewidth. In a second experiment, working at the fundamental frequency, saturation spectroscopy of /sup 13/C/sub 2/H/sub 2/ was achieved using a low-pressure gas cell inside a build-up cavity. The measured absorption dip has 3% line contrast and 1.2 MHz linewidth. Both the atomic and molecular saturated lines are very well suited for frequency locking in order to establish accurate frequency standards in the optical communication band.
Using Utility to Provision Storage Systems (CMU-PDL-07-106) (2018)

Provisioning a storage system requires balancing the costs of the solution with the benefits that the solution will provide. Previous provisioning approaches have started with a fixed set of requirements and the goal of automatically finding minimum cost solutions to meet them. Those approaches neglect the cost-benefit analysis of the purchasing decision. Purchasing a storage system involves an extensive set of trade-offs between metrics such as purchase cost, performance, reliability, availability, power, etc. Increases in one metric have consequences for others, and failing to account for these trade-offs can lead to a poor return on the storage investment. Using a collection of storage acquisition and provisioning scenarios, we show that utility functions enable this cost-benefit structure to be conveyed to an automated provisioning tool, enabling the tool to make appropriate trade-offs between different system metrics including performance, data protection, and purchase cost.
Reaping the catalytic benefits of both surface (NiFe2O4) and underneath (Ni3Fe) layers for the oxygen evolution reaction (2021)

Facile growth of a crystalline monolayer of NiFe<sub>2</sub>O<sub>4</sub> encompassing Ni<sub>3</sub>Fe embedded within a polyaniline matrix for the oxygen evolution reaction.
Scalable Open-Air Deposition of Compact ETL TiOx on Perovskite for Fullerene-Free Solar Cells (2020)

We report on a scalable, low-temperature TiOx electron transport layer (ETL) produced directly on top of perovskite in an inverted architecture device by an open-air chemical vapor deposition (OA-CVD) process. The OA-CVD pyrolysis of a titanium ethoxide precursor forms a fully inorganic, conformal, and compact TiOx film. The resultant film is mechanically robust and exhibits a fracture toughness 30-fold higher than commonly used fullerene-based ETL films. The TiOx is an effective barrier layer against environmental degradation—unencapsulated devices with the TiOx ETL retain 60% of their initial efficiency after 1000 hours in ambient aging conditions—compared to devices with a fullerene ETL which were inoperable after 144 hours. Inverted architecture devices with an optimized TiOx ETL thickness of 70nm exhibited high open-circuit voltages of 1.08V. We comment on the photocatalytic properties of TiOx and the influence of an amorphous film on maximum power point stability.
Adaptive filtering algorithms for promoting sparsity (2004)

We provide a mathematical framework for developing adaptive filtering algorithms for exploiting/enforcing sparsity. The approach is based on minimizing a regularized mean squared error criterion with sparsity being promoted by the regularizing term which consists of a diversity measure. A steepest descent algorithm (SDA) is developed to minimize the regularized cost function. Then we extend the algorithm to the adaptive environment and develop a class of algorithms, which we term the pLMS algorithm class and which incudes important variants - pLLMS (leaky pLMS) and pNLMS (normalized pLMS). The framework is quite general and encompasses a broad range of adaptive algorithms with the pNLMS having similarity with the proportionate normalized least-mean-squares (PNLMS) algorithm. Computer simulations have been conducted using the echo canceller application as an example of a sparse environment. The simulations clearly show the ability of the developed algorithms to exploit the inherent sparsity structure, thereby outperforming conventional algorithms like the NLMS algorithm in this application.
Magnetic field effect on YBCO/PBCO/YBCO Josephson junctions (1993)

Using magnetic field effects, the barrier-layer thickness dependence of the critical-current normal-resistance product (I/sub c/R/sub n/) of a-axis-oriented YBa/sub 2/Cu/sub 3/O/sub 7- delta //PrBa/sub 2/Cu/sub 3/ O/sub 7- delta //YBa/sub 2/Cu/sub 3/O/sub 7- delta / Josephson junctions exhibiting a clear magnetic field dependence has been experimentally obtained. Since the magnetic penetration depth of an a-axis-oriented thin film is large, the Josephson penetration depth of the junction easily becomes less than the junction-length, and the observed I/sub c/ is no longer equal to the product of the critical current density j/sub c/ and the junction area A when j/sub c/ approaches 1 kA/cm/sup 2/. The authors studied the magnetic field effects on the junction to evaluate the intrinsic I/sub c/ defined by j/sub c/A under such a condition, and evaluated the I/sub c/R/sub n/-values as j/sub c/AR/sub n/ by using the results. The maximum values of j/sub c/ and I/sub n/R/sub n/ were 310 A/cm/sup 2/ and 170 mu V, respectively, at 4 K for a junction with a 25-nm-thick PrBa/sub 2/Cu/sub 3/O/sub 7- delta /, barrier-layer. The intrinsic I/sub c/R/sub n/-value was found to increase exponentially with decrease in the barrier layer thickness.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Germline EMSY sequence alterations in hereditary breast cancer and ovarian cancer families (2017)

These results suggest that the identified EMSY variants are likely neutral at the population level. However, these variants may contribute to breast/ovarian cancer risk in single families. Additional analyses are warranted for rare novel intronic deletions and the 3'UTR variants predicted to have functional roles.
Self‐Assembled Aggregates of IgGs as Templates for the Growth of Clusters of Gold Nanoparticles (2004)

Immunglobulin-G-Template: Cluster von Gold-Nanopartikeln (siehe Bild) wachsen um Template aus selbstorganisierten IgGs, die durch synthetische zweibindige Antigene verbunden sind. Kohlenhydrate, die Bestandteile der IgGs sind, wirken dabei als Keimstellen für die stromlose Goldabscheidung. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2004/z53161_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Perinatal antidepressant exposure alters cortical network function in rodents (2011)

Serotonin (5-HT) plays a key role in early brain development, and manipulation of 5-HT levels during this period can have lasting neurobiological and behavioral consequences. It is unclear how perinatal exposure to drugs, such as selective serotonin reuptake inhibitors (SSRIs), impacts cortical neural network function and what mechanism(s) may elicit the disruption of normal neuronal connections/interactions. In this article, we report on cortical wiring organization after pre- and postnatal exposure to the SSRI citalopram. We show that manipulation of 5-HT during early development in both in vitro and in vivo models disturbs characteristic chemoarchitectural and electrophysiological brain features, including changes in raphe and callosal connections, sensory processing, and myelin sheath formation. Also, drug-exposed rat pups exhibit neophobia and disrupted juvenile play behavior. These findings indicate that 5-HT homeostasis is required for proper brain maturation and that fetal/infant exposure to SSRIs should be examined in humans, particularly those with developmental dysfunction, such as autism.
Rate of Scoliosis Correction After Anterior Spinal Growth Tethering for Idiopathic Scoliosis (2021)

Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Abstract 3770: HEXIM1 as a pharmacodynamic marker for monitoring target engagement of ABBV-075 (2016)

Abstract Bromodomain and extra-terminal (BET) family are dual bromodomain-containing proteins that play an important role in transcription regulation. ABBV-075 is a small molecule BET bromodomain inhibitor currently in phase 1 clinical trials. Here we report the identification of Hexim1 and other BET-responsive genes as robust pharmacodynamic markers for monitoring ABBV-075 target engagement in tumors and in surrogate tissues such as whole blood and skin. Transcription profiling of cancer cell lines for their responses to BET inhibitors identified a set of 9 BET-regulated genes, including Hexim1, that responded to BET inhibition across cancer cell lines and in xenograft tumors. Further characterization of BET-responsive genes in surrogate tissues such as mouse skin, mouse/human PBMCs and whole blood revealed that the mRNA level of Hexim1 exhibited the best response to BETi treatment across different settings. A dose-dependent increase of Hexim1 expression was detected in the whole blood of ABBV-075 treated tumor bearing mice, and the Hexim1 response was closely correlated with the plasma drug concentration and largely reflected the anti-tumor efficacy at various dose levels of ABBV-075. Hexim1 is part of a protein/RNA complex that sequesters pTEFb and prevents its recruitment by BRD4. It also reportedly mediates the anti-proliferative activity of BRD4 in AML. Taken together, Hexim1 could serve as a functional relevant pharmacodynamic marker for monitoring ABBV-075 target engagement in animal models and in the clinical setting. Citation Format: Xiaoli Huang, Xiaoyu Lin, Leiming Li, Rongqi Wang, Lisa Roberts, Paul Hessler, Tamar Uziel, Lloyd Lam, Terry Magoc, Daniel H. Albert, Steven W. Elmore, Guowei Fang, Saul H. Rosenberg, Keith McDaniel, Warren Kati, Yu Shen. HEXIM1 as a pharmacodynamic marker for monitoring target engagement of ABBV-075. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3770.
Editorial: Proteomics 7/2003 (2003)

Abstract No abstracts.
N-butyldeoxynojirimycin-mediated inhibition of human immunodeficiency virus entry correlates with changes in antibody recognition of the V1/V2 region of gp120 (1996)

The alpha-glucosidase inhibitor N-butyldeoxynojirimycin (NB-DNJ) is an inhibitor of human immunodeficiency virus (HIV) replication and HIV-induced syncytium formation in vitro. Although NB-DNJ appears to inhibit HIV entry at the level of post-CD4 binding (P.B. Fischer, M. Collin, G.B. Karlsson, W. James, T.D. Butters, S.J. Davis, S. Gordon, R.A. Dwek, and F.M. Platt, J. Virol. 69:5791-5797, 1995), the exact mechanism of action remains to be established. In this study we have examined the effect of NB-DNJ on the structure of recombinant gp120 (rgpl20), expressed in CHO cells, by using a panel of 40 monoclonal antibodies. The levels of binding of antibodies to rgp120 produced in the presence [rgpl20(+)] and absence [rgpl20(-)] of NB-DNJ were compared by enzyme-linked immunosorbent assay and surface plasmon resonance (BIAcore; Pharmacia). The results showed an increase in the binding to rgp120(+) of antibodies directed against the C1 and C2 regions and a decrease in the binding of antibodies directed against the V1/V2 loops compared with antibody binding to rgpl20(-). A decrease in the binding to rgpl20(+) of antibodies directed against discontinuous epitopes was also observed. No differences were seen in the binding of antibodies directed against the crown of the V3 loop and the C4 region of gp120. Treatment of rgpl20 with alpha-glucosidases I and II had no effect on the differential binding observed, whereas treatment with sialidase abolished the differences seen in the binding of antibodies directed against the C1 and C2 regions of gp120. In addition to these findings, rgpl20(+) showed increased sensitivity to proteases released by CHO cells during expression, as well as to exogenous thrombin. Taken together, the data presented in this paper suggest that production of gp120 in the presence of NB-DNJ affects the conformation of the Vl/V2 loops of gpl20, as well as the overall charge of the C1 and C2 regions. These effects may play a role in the previously described NB-DNJ-mediated inhibition of HIV entry at the level of post-CD4 binding.
Scalability of wireless networks capacity with power control (2006)

Reference (1) showed that wireless networks with capacity scalable with the number of nodes, n, are achievable in theory. The transport capacity scales as ) ( n Θ , while the capacity scales as ) (n Θ . Reference (2), on the other hand, showed that the capacity of IEEE 802.11 networks does not scale with n due to its carrier sensing mechanism. The previous work, however, has not considered the use of power control. The main contributions of this paper are two-fold: 1) the demonstration that 802.11 networks are scalable with power control; 2) however, with power control, an enhanced MAC protocol called Selective Disregard of NAVs (SDN) can achieve substantially higher capacity. Specifically, capacity within 90% of the theoretical optimal capacity of infrastructure networks is achievable.