gebhart/patrepeval huggingface dataset:
Egghead and Brainiac Are Essential for Glycosphingolipid Biosynthesis in Vivo (2004)

The Drosophila genes, brainiac and egghead, encode glycosyltransferases predicted to act sequentially in early steps of glycosphingolipid biosynthesis, and both genes are required for development in Drosophila. egghead encodes a beta4-mannosyltransferase, and brainiac encodes a beta3-N-acetylglucosaminyltransferase predicted by in vitro analysis to control synthesis of the glycosphingolipid core structure, GlcNAcbeta1-3Manbeta1-4Glcbeta1-Cer, found widely in invertebrates but not vertebrates. In this report we present direct in vivo evidence for this hypothesis. egghead and brainiac mutants lack elongated glycosphingolipids and exhibit accumulation of the truncated precursor glycosphingolipids. Furthermore, we demonstrate that despite fundamental differences in the core structure of mammalian and Drosophila glycosphingolipids, the Drosophila egghead mutant can be rescued by introduction of the mammalian lactosylceramide glycosphingolipid biosynthetic pathway (Galbeta1-4Glcbeta1-Cer) using a human beta4-galactosyltransferase (beta4Gal-T6) transgene. Conversely, introduction of egghead in vertebrate cells (Chinese hamster ovary) resulted in near complete blockage of biosynthesis of glycosphingolipids and accumulation of Manbeta1-4Glcbeta1-Cer. The study demonstrates that glycosphingolipids are essential for development of complex organisms and suggests that the function of the Drosophila glycosphingolipids in development does not depend on the core structure.
Explore/exploit strategic movement of co-occurrence network based on a conscious/subconscious model (2015)

Computation learning from living organisms should be useful for adapting to uncomputable problems in complex social systems. According to an interpretation of Gödel's incompleteness theorems, a human is a “more than Turing computation (MTTC)” system consisting of a Turing machine represented as a computable recursive function and an environmental interaction represented as an oracle function. Recent findings from both science and philosophy show that a human is an autopoietic system that reproduces itself by recursion of consciousness and subconsciousness with self-reference and contingency. Using an approach combining MTTC and autopoiesis, we propose a conscious/subconscious model in which subconscious/necessary recursion and conscious/contingent recursion circulate doubly with environmental interaction. Application of this model to a web search with user interaction revealed that the co-occurrence network shows strategic movement in which the exploitation of known information is balanced against the exploration of unknown information. This movement indicates that our conscious/subconscious model is an MTTC/autopoietic system that improves the fitness for the uncomputable problem of ambiguous user expectation.
Validation of Blood Flow Computations Using Analytical, In Vitro, and In Vivo Methods (1998)

Abstract Computational investigations of blood flow require validation using analytical solutions and in vitro and in vivo experimental methods. Analytical solutions to the Navier-Stokes equations are possible in only a few select cases with very special geometry and boundary conditions. Fortunately, a canonical solution for pulsatile flow does exist: the Womersley solution for fully developed pulsatile flow in a straight circular cylinder. This analytical solution is essential in assessing the accuracy of numerical methods and examining such important issues as spatial and temporal discretization errors. In vitro experimental investigations can be used to validate computational solutions for blood flow in rigid and deformable models of complex geometries. Detailed information on velocity fields can be obtained using Laser Doppler Anemometry (LDA) and Particle Image Velocimetry (PIV). Although analytical and in vitro experimental methods are extremely important tools for validating numerical solutions, ultimately in vivo measurements, utilizing ultrasound or magnetic resonance imaging, must be utilized for validating predictions made with numerical methods. Computational solutions for blood flow in a straight cylindrical vessels are validated using Womersley’s analytic solution. Computational solutions for flow in a model of an end-to-side anastomosis are validated by comparing predicted velocity profiles with those obtained by Loth (1993) using LDA. Magnetic resonance imaging of blood flow in the aorta was performed during dynamic exercise conditions to investigate whether numerically predicted changes in infrarenal blood flow are observed in vivo.
Relationship ofMycoplasma pneumoniaeto Other HumanMycoplasmaSpecies Studied by Gel Diffusion (1965)

Taylor-Robinson, David (National Institute of Allergy and Infectious Diseases, Bethesda, Md.), Otakar Sobeslavský, and Robert M. Chanock. Relationship of Mycoplasma pneumoniae to other human Mycoplasma species studied by gel diffusion. J. Bacteriol. 90:1432-1437. 1965.-Conditions are presented for the production of four lines of precipitate between Mycoplasma pneumoniae antigen and homologous hyperimmune rabbit serum in double diffusion in agar. The specificity of the reaction was shown by the fact that M. pneumoniae antigen did not react with antisera to the other human mycoplasma species, nor did M. pneumoniae antiserum produce lines with antigens prepared from the other human mycoplasmas. In addition, there was no reduction in the number or intensity of precipitation lines after absorption of M. pneumoniae antiserum with heterotypic mycoplasma antigens, or after absorption of heterotypic mycoplasma antisera with M. pneumoniae antigen. These findings indicate that, of the human mycoplasma species so far studied, M. pneumoniae is antigenically the most distinct.
Reinforcement Learning for Transition-Based Mention Detection (2017)

This paper describes an application of reinforcement learning to the mention detection task. We define a novel action-based formulation for the mention detection task, in which a model can flexibly revise past labeling decisions by grouping together tokens and assigning partial mention labels. We devise a method to create mention-level episodes and we train a model by rewarding correctly labeled complete mentions, irrespective of the inner structure created. The model yields results which are on par with a competitive supervised counterpart while being more flexible in terms of achieving targeted behavior through reward modeling and generating internal mention structure, especially on longer mentions.
Isoforms of the Na-K-2Cl cotransporter in murine TAL I. Molecular characterization and intrarenal localization (1999)

We have identified several alternatively spliced cDNAs encoding mBSC1, an apical bumetanide-sensitive Na+-K+-2Cl- cotransporter from mouse kidney. Two full-length clones were isolated, designated C4 and C9, predicting proteins of 770 and 1,095 amino acids, respectively. The C4 isoforms are generated by utilization of an alternative polyadenylation site located within the intron between exons 16 and 17 of the mBSC1 gene on chromosome 2; the resultant transcripts predict a truncated COOH terminus ending in a unique 55 amino acid sequence. The predicted C4 and C9 COOH termini differ in the distribution of putative phosphorylation sites for both protein kinase A and C. Independent splicing events involve three previously described cassette exons, which are predicted to encode most of the second transmembrane domain. A total of six different isoforms are expressed, generated by the combinatorial association of three cassette exons and two alternative 3' ends. C9-specific and C4-specific antibodies detect proteins of approximately 150 and 120 kDa, respectively, in mouse kidney. Immunofluorescence and immunohistochemistry indicate expression of both COOH-terminal isoforms within the thick ascending limb of the loop of Henle (TAL). However, staining with the C4 antibody is more heterogeneous, with a decreased proportion of positive cells in the cortical TAL. Functional expression in Xenopus oocytes indicates a dominant negative function for C4 isoforms [companion study, C. Plata, D. B. Mount, V. Rubio, S. C. Hebert, and G. Gamba. Am. J. Physiol. 276 (Renal Physiol. 45): F347-F358, 1999], and the differential expression of these isoforms may contribute to functional heterogeneity of Na+-K+-2Cl- cotransport in mouse TAL.
Synthetic Porous Melanin (2021)

Commonly known as a skin pigment, melanin has a vital role in UV radiation protection, primarily acting as a radical scavenger. However, a lesser known natural property of melanin, observed in some melanized organisms, is its capacity to adsorb toxins, including metals and organic molecules. Inspired by this, we set out to generate a synthetic porous melanin that would pave the way to enhancing the natural adsorbent properties of melanin and melanin-like materials. Here, we developed a method for the synthesis of porous polydopamine-based melanin utilizing a mesoporous silica (MS) nanoparticle template and characterized its physical properties. Through the oxidative polymerization of dopamine, followed by the etching of silica, we generated synthetic porous melanin (SPM) with the highest measured surface area of any known polydopamine-based material. The prepared SPM was effective for the uptake of various gases and organophosphate toxins, with the material exhibiting high selectivity for CO<sub>2</sub> over CH<sub>4</sub> and high potential for ammonia capture. Given the demonstrated advantages provided by synthetic porous melanin and melanin's role as an adsorbent in nature, we anticipate the discovery of porous analogues in biological systems.
ChemInform Abstract: Boron Trifluoride Assisted Perfluoroalkylation of Carbon‐Nitrogen Double Bonds. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Online bioimpedance feedback forin vivoelectroporated tissues (2010)

Electroporation in vivo is a biotechnology method that uses short-duration high intensity electric fields to enhance plasma membrane permeability in living cells in order to facilitate the uptake of drugs, DNA, genes and proteins into the cytoplasm. The degree of permeability is related to the tissue's bioimpedance; hence, accurate impedance evaluation throughout electroporation treatment is essential to 1) avoid over-treating tissues resulting in excessive cell death and 2) under-treating tissues resulting in poor permeability. Cell viability and membrane permeability is based on a number of factors, including: time elapsed after electroporation, electroporation pulse amplitude, tissue type, and so on; thus, efficient feedback protocols must minimize delays between treatment and impedance readings. Current methods of bioimpedance feedback are often cumbersome and impedance analysis devices can be expensive, bulky, and immobile. Emerging technologies facilitate economical methods, fast protocols, and portability to realize bioimpedance measurement and feedback online (i.e. realtime). Consequently, this research uses automation software, logic-biased protocols, an inexpensive commercially available impedance analyzer microchip, and a custom-built hexagonal electrode probe to measure dynamic bioimpedance changes. This work demonstrates how this novel system measures tissue bioimpedance instantly and efficiently before and after electroporation. Additionally this system allows for the comparison of electrode geometries as well as electric field' magnitudes and distributions. Follow up work will pursue the optimization of plasma membrane permeability for several tissue/cell types.
Lymphangiogenic growth factors, receptors and therapies (2003)

The lymphatic vasculature is essential for the maintenance of normal fluid balance and for the immune responses, but it is also involved in a variety of diseases. Hypoplasia or dysfunction of the lymphatic vessels can lead to lymphedema, whereas hyperplasia or abnormal growth of these vessels are associated with lymphangiomas and lymphangiosarcomas. Lymphatic vessels are also involved in lymph node and systemic metastasis of cancer cells. Recent novel findings on the molecular mechanisms involved in lymphatic vessel development and regulation allow the modulation of the lymphangiogenic process and specific targeting of the lymphatic endothelium. Recent results show that the homeodomain transcription factor Prox-1 is an important lymphatic endothelial cell (LEC) fate-determining factor which can induce LEC-specific gene transcription even in blood vascular endothelial cells (BECs). This suggests that the distinct phenotypes of cells in the adult vascular endothelium are plastic and sensitive to transcriptional reprogramming, which might be useful for future therapeutic applications involving endothelial cells. Vascular endothelial growth factor-C (VEGF-C) and VEGF-D are peptide growth factors capable of inducing the growth of new lymphatic vessels in vivo in a process called lymphangiogenesis. They belong to the larger family which also includes VEGF, placenta growth factor (PlGF) and VEGF-B, VEGF-C and VEGF-D are ligands for the endothelial cell specific tyrosine kinase receptors VEGFR-2 and VEGFR-3. In adult human as well as mouse tissues VEGFR-3 is expressed predominantly in lymphatic endothelial cells which line the inner surface of lymphatic vessels. While VEGFR-2 is thought to be the main mediator of angiogenesis, VEGFR-3 signaling is crucial for the development of the lymphatic vessels. Heterozygous inactivation of the VEGFR-3 tyrosine kinase leads to primary lymphedema due to defective lymphatic drainage in the limbs. Other factors that seem to be involved in lymphangiogenesis include the Tie/angiopoietin system, neuropilin-2 and integrin alpha 9. VEGF-C induces lymphatic vessel growth, but high levels of VEGF-C also resulted in blood vessel leakiness and growth. The VEGFR-3-specific mutant form of VEGF-C called VEGF-C156S lacks blood vascular side effects but is sufficient for therapeutic lymphangiogenesis in a mouse model of lymphedema. As VEGF-C156S is a specific lymphatic endothelial growth factor in the skin, it provides an attractive molecule for pro-lymphangiogenic therapy.
ABSTRACT: SEISDIP: the VSP dipmeter"from oriented 3 components" (2001)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Dynamic Analysis and Diagnostics of a High Temperature PEM Fuel Cell Stack (2013)

In this work, impedance measurement was performed on a high temperature PEM fuel cell stack module consisting of 65 planar single cells. Pure hydrogen and ambient air were supplied into the stack. The impedance data of the stack were collected under varying loads at 160ºC. However, temperature variations and gradient existed over the whole stack during the measurement. The impedance measurement was then repeated under the same operating conditions to collect the second set of data. An unexpected increase of cell impedance was observed. An EC diagram was derived to simulate the impedance data of the stack module. The electronic auxiliaries and temperature profiles of the stack module were analyzed to study their effects on stack impedance.
Stabilization of an Electroless Platinum Plating Bath Using S-Bearing Additives (2015)

Moderation of an electroless platinum plating bath by thiol, thioether, disulfide, thiocarbonyl, thiosulfate and sulfide compounds was investigated. The inhibitory effect of stabilizers on catalyzed anodic oxidation of the reducing agent used, sodium borohydride, on platinum surfaces was electrochemically characterized by linear sweep voltammetry. Catalytic oxidation inhibition was found to correlate with chemisorption dynamics to catalytic sites on the platinum surface and the steric structure of the sulfur in the compound. Evaluation of the compounds as moderators in electroless plating revealed that the deposition rate and bath stability correlated with the sodium borohydride oxidation inhibition character. Tiopronin had a moderate inhibitory effect on catalytic sodium borohydride oxidation and functioned as an effective stabilizer in the electroless platinum plating bath. Based on the correlation, an inhibitor concentration optimization method using anodic polarization curves was established. The dynamics of the electroless plating reaction concurred with electrochemical analysis and was comprehensively described by the mixed potential theory. Using cyclic voltammetry, the deposits had similar electrochemical characteristic to that of pure polycrystalline platinum, although less than 0.5 wt% sulfur inclusion was confirmed by elemental analysis.
DeepDB (2020)

The typical approach for learned DBMS components is to capture the behavior by running a representative set of queries and use the observations to train a machine learning model. This workload-driven approach, however, has two major downsides. First, collecting the training data can be very expensive, since all queries need to be executed on potentially large databases. Second, training data has to be recollected when the workload or the database changes. To overcome these limitations, we take a different route and propose a new data-driven approach for learned DBMS components which directly supports changes of the workload and data without the need of retraining. Indeed, one may now expect that this comes at a price of lower accuracy since workload-driven approaches can make use of more information. However, this is not the case. The results of our empirical evaluation demonstrate that our data-driven approach not only provides better accuracy than state-ofthe- art learned components but also generalizes better to unseen queries.
Optical propagation in a marine environment: effects of turbulence spectrum choice on simulation (2022)

Optical propagation in a marine environment is important to understand for many applications. In particular, free space optical communication can be significantly impacted by surges and fades in signal strength caused by scintillation. For over ten years, the United States Naval Research Laboratory has maintained a 16 km free space optical link across the Chesapeake Bay at our Lasercom Test Facility. This laboratory has continuously recorded scintillation, as well as environmental parameters. Recently, we have begun a modeling and simulation effort. Fundamental models like the Naval Postgraduate School’s NAVSLaM are used to predict turbulence parameters based on weather measurements. Wave optics simulation, using these parameters, is then used to predict scintillation. These predictions are then compared to measurements. Wave optics simulation requires an underlying model of the spectrum of turbulence. A variety of turbulence spectra have been proposed, including the Kolomogorov, Von Karman, Hill and Marine spectra. In this talk we compare wave optics simulation, using these spectra, to experimental measurements, and examine which spectra best match the data.
Exotica/FMDC: Handling Disconnected Clients in a Workflow Management System. (1995)

Workflow Management Systems (WFMS) are a first generation of products that attempt to manage the execution of business processes by large numbers of users distributed over a wide area and using heterogeneous resources. They are a very promising venue for collaborative systems but, in most cases, the autonomy of the users is greatly restricted due to architectural and design considerations. This is a severe restriction, especially when considering the emergence of mobile computing, and the increase in use of laptops and small computers which are connected to a network only occasionally. In this paper, we discuss how disconnected workflow clients can be supported while preserving the correctness of the overall execution and allowing coordinated interactions between the different users. Disconnected client support provides a great deal of flexibility in the usability of a WFMS and enhances the system&amp;apos;s resilience to failures. 1 Introduction The recent increase in the availability of pow...
Maxillary Ridge Augmentation with Custom-Made CAD/CAM Scaffolds. A 1-Year Prospective Study on 10 Patients (2013)

Several procedures have been proposed to achieve maxillary ridge augmentation. These require bone replacement materials to be manually cut, shaped, and formed at the time of implantation, resulting in an expensive and time-consuming process. In the present study, we describe a technique for the design and fabrication of custom-made scaffolds for maxillary ridge augmentation, using three-dimensional computerized tomography (3D CT) and computer-aided design/computer-aided manufacturing (CAD/CAM). CT images of the atrophic maxillary ridge of 10 patients were acquired and modified into 3D reconstruction models. These models were transferred as stereolithographic files to a CAD program, where a virtual 3D reconstruction of the alveolar ridge was generated, producing anatomically shaped, custom-made scaffolds. CAM software generated a set of tool-paths for manufacture by a computer-numerical-control milling machine into the exact shape of the reconstruction, starting from porous hydroxyapatite blocks. The custom-made scaffolds were of satisfactory size, shape, and appearance; they matched the defect area, suited the surgeon's requirements, and were easily implanted during surgery. This helped reduce the time for surgery and contributed to the good healing of the defects.
Le concept "Archaebiotics", vers de nouveaux probiotiques préventifs des maladies cardiovasculaires ? (2013)

Communication orale: Brugère J.F.<br/>Communication orale: Brugère J.F.
Surface normal photonic crystal waveguide coupling for N/sup 3/ distributed optoelectronic crossbar (2004)

The realization of the N/sup 3/ distributed optoelectronic crossbar requires the incorporation of bidirectional transceiver modules. The current design philosophy of these modules in their single wavelength configuration consist of the integration of VCSEL and RCE detection devices monolithically integrated with a bidirectional common waveguide. Coupling into this common waveguide is currently under investigation utilizing two methods 1.) surface normal coupling using a buried grating coupler external but monolithic surface normal coupling utilizing photonic crystal. This paper will briefly discuss the first method and its drawbacks which motivate the second photonic crystal implementation method. Our initial design work has been accomplished at 980 nm. The measure reflectance spectrum of the VCSEL/PD epitaxy structure prior to the fabrication of the photonic crystal coupler and waveguide layer.
An Unusual Intramolecular Hetero-Diels−Alder Cycloaddition (2005)

A new reaction of erythronolides, an intramolecular hetero-Diels-Alder, has been discovered. Heated aqueous alcoholic solutions of ABT-773 (1) and its cis isomer (3) convert slowly to cycloadducts 2 and 4, respectively. Optimal reaction conditions, mechanistic studies supported by molecular modeling, and biological activity data are reported. Single-crystal X-ray structures for both adducts 2 and 4 have been obtained.