gebhart/patrepeval huggingface dataset:
Influence of the procedure of nickel deposition on the textural and catalytic properties of nickel/sepiolite catalysts (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfluence of the procedure of nickel deposition on the textural and catalytic properties of nickel/sepiolite catalystsA. Corma, A. Mifsud, and J. Perez ParienteCite this: Ind. Eng. Chem. Res. 1988, 27, 11, 2044–2050Publication Date (Print):November 1, 1988Publication History Published online1 May 2002Published inissue 1 November 1988https://pubs.acs.org/doi/10.1021/ie00083a014https://doi.org/10.1021/ie00083a014research-articleACS PublicationsRequest reuse permissionsArticle Views215Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Quality of Life and Adverse Events: Prognostic Relationships in Long-Term Ovarian Cancer Survival (2021)

Baseline and longitudinal QOL change scores distinguished LTS vs STS and are robust prognosticators for long-term survival. Results have trial design and supportive care implications, providing meaningful prognostic value in this understudied population.
Cost-efficient modeling of antenna structures using Gradient-Enhanced Kriging (2015)

Reliable yet fast surrogate models are indispensable in the design of contemporary antenna structures. Data-driven models, e.g., based on Gaussian Processes or support-vector regression, offer sufficient flexibility and speed, however, their setup cost is large and grows very quickly with the dimensionality of the design space. In this paper, we propose cost-efficient modeling of antenna structures using Gradient-Enhanced Kriging. In our approach, the training data set contains, apart from the EM-simulation responses of the structure at hand, also derivative data at the respective training locations obtained at little extra cost using adjoint sensitivity techniques. We demonstrate that introduction of the derivative information into the model allows for considerable reduction of the model setup cost (in terms of the number of training points required) without compromising its predictive power. The Gradient-Enhanced Kriging technique is illustrated using a dielectric resonator antenna structure. Comparison with conventional Kriging interpolation is also provided.
Combining multiple kernels for efficient image classification (2009)

We investigate the problem of combining multiple feature channels for the purpose of efficient image classification. Discriminative kernel based methods, such as SVMs, have been shown to be quite effective for image classification. To use these methods with several feature channels, one needs to combine base kernels computed from them. Multiple kernel learning is an effective method for combining the base kernels. However, the cost of computing the kernel similarities of a test image with each of the support vectors for all feature channels is extremely high. We propose an alternate method, where training data instances are selected, using AdaBoost, for each of the base kernels. A composite decision function, which can be evaluated by computing kernel similarities with respect to only these chosen instances, is learnt. This method significantly reduces the number of kernel computations required during testing. Experimental results on the benchmark UCI datasets, as well as on a challenging painting dataset, are included to demonstrate the effectiveness of our method.
Detection of phosphoproteins on electroblot membranes using a small‐molecule organic fluorophore (2004)

A new formulation of the small-molecule organic fluorophore, Pro-Q Diamond dye, has been developed that permits rapid and simple detection of phosphoproteins directly on polyvinylidene difluoride (PVDF) or nitrocellulose membranes (electroblots). Protein samples are first separated by electrophoresis and then electroblotted to membranes, stained and destained, in an analogous manner as typically performed with Amido Black or Ponceau S dye staining of total protein profiles. After staining, blots are imaged using any of a variety of laser-based gel scanners, xenon-arc lamp-based gel scanners or charge-coupled device (CCD) camera-based imaging devices equipped with UV trans- or epi-illumination. The uncomplicated and reliable staining protocol delivers results in as little as 1 h and the limit of detection for the stain is typically 2-4 ng of phosphoprotein with a linear dynamic range of approximately 15-fold. Compared with traditional radiolabeling and antibody-based approaches, the new method offers significant advantages, including avoidance of radioactivity, no need for expensive antibodies, no requirement for blocking unoccupied sites on the membrane with protein or detergent solutions, no sequence context-specific binding to phosphorylated amino acid residues and the ability to analyze the native, steady-state phosphorylation of proteins obtained directly from tissue specimens or body fluids. Pro-Q Diamond dye binds directly and exclusively to the phosphate moiety, allowing it to detect the broadest spectrum of phosphorylated proteins possible. The stain binds noncovalently to phosphoproteins and is thus fully compatible with matrix-assisted laser desorption/ionization-time of flight-mass spectrometry (MALDI-TOF-MS) or Edman sequencing. The blot stain is also compatible with standard colorimetric, fluorogenic, and chemiluminescent detection techniques employed in immunoblotting.
Low-loss dispersion-shifted single-mode fiber manufactured by the OVD process (1985)

The development of a low-loss dispersion-shifted single-mode fiber with a segmented-core profile is reported. The combination of low dispersion in the 1550-nm window, 0.21-dB/km median attenuation at 1550 nm, excellent bend resistance ( <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\lambda_{c} = 1200</tex> nm), and good splicing behavior make this fiber an economically viable alternative for long-haul high-data-rate operation utilizing multilongitudinal mode lasers. System experiments have demonstrated bit rates as high as 1.3 Gbit/s over 107 km and repeaterless spans of up to 233 km.
13.3: Improvement in Temperature Durability of Bendable Electronic Paper Using Cholesteric Liquid Crystals ChLC (2011)

Abstract Liquid crystal elements used to bond upper and lower substrates with adhesive column spacers, and thus prevent cell gap variations when bent, had problems with the spacers peeling at high temperatures and with the ChLC elements foaming at low temperatures. We developed a new flexible type of e‐paper that does not have problems of foaming or peeling in a temperature range of −15 to 70°C, by forming spacers with an extremely high coefficient of thermal expansion and suitable disposition rates.
Lysozyme: a major secretory product of a human colon carcinoma cell line (1985)

One of the major proteins secreted by an established human colon adenocarcinoma cell line has been isolated in 25% yield from the serum-free medium in which the cells were grown and identified as lysozyme. Its purification was achieved by sequential steps of acidification, cation-exchange chromatography, and reversed-phase high-performance liquid chromatography. It was recognized to be a human lysozyme on the basis of its molecular weight (14 000), isoelectric point (10.5), amino acid composition, and enzymatic activity. Its identity with previously characterized human lysozymes was established by amino-terminal sequence, peptide composition, immunological properties, NMR, and crystallography. A 4-day, 7-L collection of conditioned medium contained 20.3 mg of secreted protein of which 4.9 mg or approximately 24% of the total was tumor-derived lysozyme. The intracellular level of lysozyme was approximately 18 ng per 10(6) carcinoma cells. The possible significance of these findings in regard to the malignant process and tumor maintenance is discussed.
MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM (2019)

Activation of the Met receptor tyrosine kinase, either by its ligand, hepatocyte growth factor (HGF), or via ligand-independent mechanisms, such as <i>MET</i> amplification or receptor overexpression, has been implicated in driving tumor proliferation, metastasis, and resistance to therapy. Clinical development of Met-targeted antibodies has been challenging, however, as bivalent antibodies exhibit agonistic properties, whereas monovalent antibodies lack potency and the capacity to down-regulate Met. Through computational modeling, we found that the potency of a monovalent antibody targeting Met could be dramatically improved by introducing a second binding site that recognizes an unrelated, highly expressed antigen on the tumor cell surface. Guided by this prediction, we engineered MM-131, a bispecific antibody that is monovalent for both Met and epithelial cell adhesion molecule (EpCAM). MM-131 is a purely antagonistic antibody that blocks ligand-dependent and ligand-independent Met signaling by inhibiting HGF binding to Met and inducing receptor down-regulation. Together, these mechanisms lead to inhibition of proliferation in Met-driven cancer cells, inhibition of HGF-mediated cancer cell migration, and inhibition of tumor growth in HGF-dependent and -independent mouse xenograft models. Consistent with its design, MM-131 is more potent in EpCAM-high cells than in EpCAM-low cells, and its potency decreases when EpCAM levels are reduced by RNAi. Evaluation of Met, EpCAM, and HGF levels in human tumor samples reveals that EpCAM is expressed at high levels in a wide range of Met-positive tumor types, suggesting a broad opportunity for clinical development of MM-131.
The fate of therapeutic nanoparticles in a model biological medium: interactions with serum albumin (2019)

International audience
Optical Study of the Cerebral Microcirculation with Coherent Hemodynamics Spectroscopy: a Paced Breathing Protocol (2014)

We applied a novel method, Coherent Hemodynamics Spectroscopy, to study the cerebral microcirculation using hemodynamic oscillations. We report microvascular transit times, blood volume, and autoregulation measurements on eleven healthy subjects.
How to hook worms [computer network security] (2005)

This paper discusses the use of intrusion detection systems to protect against the various threats faced by computer systems by way of worms, viruses and other forms of attacks. Intrusion detection systems attempt to detect things that are wrong in a computer network or system. The main problems of these systems, however, are the many false alarms they produce, their lack of resistance to both malicious attacks and accidental failures, and the constant appearance of new attacks and vulnerabilities. IBM Zurich Research Laboratory has developed a system that specifically targets worms rather than trying to prevent all breaches of computer security. Called Billy Goat, the specialized worm detection system runs on a dedicated machine connected to the network and detects worm-infected machines anywhere in it. Billy Goat has been proven effective at detecting worm-infected machines in a network. It is currently used in several large corporate intranets, and it is normally able to detect infected machines within seconds of their becoming infected. Furthermore, not only is it able to detect the presence of a worm in the network, it can even provide the addresses of the infected machines. This makes it considerably easier to remedy the problem.
Applying Ising Machines to Multi-objective QUBOs (2023)

Multi-objective optimisation problems involve finding solutions with varying trade-offs between multiple and often conflicting objectives. Ising machines are physical devices that aim to find the absolute or approximate ground states of an Ising model. To apply Ising machines to multi-objective problems, a weighted sum objective function is used to convert multi-objective into single-objective problems. However, deriving scalarisation weights that archives evenly distributed solutions across the Pareto front is not trivial. Previous work has shown that adaptive weights based on dichotomic search, and one based on averages of previously explored weights can explore the Pareto front quicker than uniformly generated weights. However, these adaptive methods have only been applied to bi-objective problems in the past. In this work, we extend the adaptive method based on averages in two ways: (i) we extend the adaptive method of deriving scalarisation weights for problems with two or more objectives, and (ii) we use an alternative measure of distance to improve performance. We compare the proposed method with existing ones and show that it leads to the best performance on multi-objective Unconstrained Binary Quadratic Programming (mUBQP) instances with 3 and 4 objectives and that it is competitive with the best one for instances with 2 objectives.
U1-Mediated Exon Definition Interactions Between AT-AC and GT-AG Introns (1996)

A minor class of metazoan introns has well-conserved splice sites with 5'-AU-AC-3' boundaries, compared to the 5'-GU-AG-3' boundaries and degenerate splice sites of conventional introns. Splicing of the AT-AC intron 2 of a sodium channel (SCN4A) precursor messenger RNA in vitro did not require inhibition of conventional splicing and required adenosine triphosphate, magnesium, and U12 small nuclear RNA (snRNA). When exon 3 was followed by the 5' splice site from the downstream conventional intron, splicing of intron 2 was greatly stimulated. This effect was U1 snRNA-dependent, unlike the basal AT-AC splicing reaction. Therefore, U1-mediated exon definition interactions can coordinate the activities of major and minor spliceosomes.
High Performance Etchable RoHS Compliant Thick Film Gold Conductor (2018)

Abstract The thick film paste manufacturers are expected to produce conductors which are lead and cadmium free, yet have excellent fired film properties and the same performance and properties as the cadmium and lead containing formulations. The fired film surface of these conductors must be defect free (i.e. imperfections, pills, agglomerates) after multiple firing steps and must perform on dielectric as well as substrates from different suppliers. Typically, the thick film gold conductors are used in high reliability applications such as medical devices, military applications, and high frequency circuits, which require robust performance at high and low temperatures, in chemically aggressive environments, or extremely humid conditions. As circuits decrease in size and become more complex, the thick film gold properties become increasingly critical. The challenge is to develop an alternative gold conductor formulation, which can print and resolve fine features (down to 4 mil lines and spaces) as well as have the ability to be etched for higher density circuit designs (down to 1–2 mil lines and spaces). Gold conductors are typically used in conjunction with other high temperature thick films so good performance after multiple firings was also a targeted requirement. Heraeus has been proactive for the past decade in the development of thick film products that are both RoHS (lead and cadmium free) as well as REACH compliant. This paper discusses the experiments that were performed in order to understand the contribution of gold powder, organic and inorganic system to improve the fired film performance. These formulations were compared against existing gold conductors including the high performance gold conductor options as well as other available standard gold conductor options. Thin wire bonding trials including both gold and aluminum wire are used to compare influences of raw materials which includes high volume wire bonding reliability including failure modes and aged wire bond adhesion at elevated temperature exposures (300°C) for extended periods of time. In order to analyze fired film morphology and link this up to wire bond performance, SEM images of the conductor surface and cross sections were conducted. These studies resulted in a newly developed thick film gold conductor paste for use in a wide variety of applications. We present wire-bonding data with gold and aluminum wire and reliability results on both 96% Al2O3 ceramic substrates as well as on top of standard dielectrics.
Telmisartan downregulates angiotensin II type 1 receptor through activation of peroxisome proliferator-activated receptor γ (2006)

Our data provides a novel insight into an effect of telmisartan: telmisartan inhibits AT1R gene expression through PPARgamma activation. The dual inhibition of angiotensin II function by telmisartan - AT1R blockade and downregulation - would contribute to more complete inhibition of the renin-angiotensin system.
ChemInform Abstract: Structural Revision of Four Coumarins from Pterocaulon Species. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Enhancement of the immunosuppressive effect of cyclosporin A by ciprofloxacin in a rat cardiac allograft transplantation model (1995)

Ciprofloxacin hyperinduces interleukin-2 production in stimulated human and mouse lymphocytes. In this study, an enhanced and prolonged interleukin-2 response was also detected in polyclonally stimulated rat splenocytes in the presence of ciprofloxacin (5-80 micrograms/ml) compared to control cells without any antibiotic. Ciprofloxacin was able to counteract the immunosuppressive effect of 10 ng/ml cyclosporin A (CyA) but did not interfere with higher CyA concentrations. In parallel, ciprofloxacin did not influence thymidine uptake in mixed lymphocyte reactions in the presence of CyA. To obtain an in vivo application of these findings, graft survival was studied by performing rat cardiac allograft transplantations in the presence or absence of CyA. Brown Norway rats served as donors and Wistar Furth rats as recipients. Ciprofloxacin was injected intraperitoneally either at a high-dose regimen (240 mg/kg per 24 h) into rats every 8th h starting 1 day before transplantation until day 21 or graft loss, or it was injected at a low and clinically relevant dose regimen (45 mg/kg per 24 h) until day 9. CyA was administered orally (10 mg/kg per 24 h) from day 1 through day 9. Ciprofloxacin given alone at a high-dose regimen resulted in a median graft survival of 14.8 days, which was significantly longer than graft survival in rats without treatment (median 8.0 days). A low-dose regimen of ciprofloxacin alone did not affect graft survival.(ABSTRACT TRUNCATED AT 250 WORDS)
Arthroscopic synovectomy, removal of loose bodies and selective biceps tenodesis for synovial chondromatosis of the shoulder (2007)

We retrospectively identified 18 consecutive patients with synovial chrondromatosis of the shoulder who had arthroscopic treatment between 1989 and 2004. Of these, 15 were available for review at a mean follow-up of 5.3 years (2.3 to 16.5). There were seven patients with primary synovial chondromatosis, but for the remainder, the condition was a result of secondary causes. The mean Constant score showed that pain and activities of daily living were the most affected categories, being only 57% and 65% of the values of the normal side. Surgery resulted in a significant improvement in the mean Constant score in these domains from 8.9 (4 to 15) to 11.3 (2 to 15) and from 12.9 (5 to 20) to 18.7 (11 to 20), respectively (unpaired t-test, p = 0.04 and p < 0.0001, respectively). Movement and strength were not significantly affected. Osteoarthritis was present in eight patients at presentation and in 11 at the final review. Recurrence of the disease with new loose bodies occurred in two patients from the primary group at an interval of three and 12 years post-operatively. In nine patients, loose bodies were also present in the bicipital groove; seven of these underwent an open bicipital debridement and tenodesis. We found that arthroscopic debridement of the glenohumeral joint and open debridement and tenodesis of the long head of biceps, when indicated, are safe and effective in relieving symptoms at medium-term review.
Hemofiltration: An Unnecessarily Complex Method to Achieve Hypotonic Sodium Removal and Controlled Ultrafiltration (1983)

High flux hemofiltration (HF) has been routinely reported to result in decreased morbidity compared to hemodialysis (HD). Examination of Na and water transport in these comparative studies indicates: (1) HF with substitution fluid sodium concentration 140 mEq/l results in hypotonic ultrafiltration over the normal range of plasma sodium: (2) the error in ultrafiltration with state of the art HD is 6 times greater than for HF and results in a 6-fold increase in Na balance error; (3) the majority of clinical studies comparing HF and HD have not been designed to achieve equal Na flux; (4) hypotonic Na removal and improved ultrafiltration control may be major determinants of decreased morbidity with HF.
Leveraging Mammalian Therapeutic Research To Identify Novel Lead Chemistries for Crop Protection (2015)

Driven by pest resistance and the ever changing demands of the market place, the discovery of new modes of action and lead chemistries with the potential to evolve into novel agricultural products is of prime importance to any crop protection discovery program. One proven inspirational resource for hypotheses which can unearth new agriculturally relevant lead chemistries is the medicinal literature. With the tremendous amount of basic and applied research being conducted to understand as well as exploit mammalian biology, biochemistry and the pathogens that act on them, new therapeutic modes of action, target site ligands and/or biologically privileged chemical motifs continually find their way to the open literature. In this paper some strategies to exploit this wealth of information to identify novel insecticidal and fungicidal lead chemistries will be discussed. Several case studies will be given to illustrate some of the advantages and drawbacks in this lead generation approach.