gebhart/patrepeval huggingface dataset:
Static classification of value predictability using compiler hints (2004)

Predicting the values that are likely to be produced by instructions has been suggested as a way of increasing the instruction-level parallelism available in a superscalar processor. One of the potential difficulties in cost-effectively predicting values for a given instruction, however, is selecting the proper type of predictor, such as a last-value predictor, a stride predictor, or a context-based predictor. We propose a compiler-directed classification scheme that statically partitions all of the instructions in a program into several groups, each of which is associated with a specific value predictability pattern. This value predictability pattern is encoded into the instructions to identify the type of value predictor that will be best suited for predicting the values that are likely to be produced by each instruction at runtime. Both a profile-based compiler implementation and an implementation based on the GCC compiler are studied to show the performance bounds for the proposed technique. Our simulations using an extension to the SimpleScalar tool set and the SPEC95 and SPEC2000 benchmark programs indicate that this approach can efficiently use the limited hardware resources in superscalar processors. This static partitioning approach produces better performance than a dynamically partitioned approach and a simple round-robin distribution approach for a given hardware configuration. Finally, we demonstrate the connection between value locality behavior and source-level program structures, thereby leading to a deeper understanding of the causes of this behavior.
Visualizing dynamic text corpora using Virtual Reality (2018)

In recent years, data visualization has become a major area in Digital Humanities research, and the same holds true also in linguistics. The rapidly increasing size of corpora, the emergence of dyn ...
Atomic layer deposition of silicon-based dielectrics for semiconductor manufacturing: Current status and future outlook (2019)

The fabrication of next-generation semiconductor devices has created a need for low-temperature (≤400 °C) deposition of highly-conformal (&amp;gt;95%) SiO2, SiNx, and SiC films on high-aspect-ratio nanostructures. To enable the growth of these Si-based dielectric films, semiconductor manufacturers are transitioning from chemical vapor deposition to atomic layer deposition (ALD). Currently, SiO2 films deposited using ALD are already being integrated into semiconductor device manufacturing. However, substantial processing challenges remain for the complete integration of SiNx films deposited by ALD, and there are no known processes for ALD of SiC at temperatures that are compatible with semiconductor device manufacturing. In this focused review, the authors look at the status of thermal and plasma-assisted ALD of these three Si-based dielectric films. For SiO2 ALD, since low-temperature processes that deposit high-quality films are known, the authors focus primarily on the identification of surface reaction mechanisms using chlorosilane and aminosilane precursors, as this provides a foundation for the ALD of SiNx and SiC, two material systems where substantial processing challenges still exist. Using an understanding of the surface reaction mechanisms, the authors describe the underlying reasons for the processing challenges during ALD of SiNx and SiC and suggest methodologies for process improvement. While both thermal and plasma-assisted SiNx ALD processes have been reported in the literature, the thermal NH3-based ALD processes require processing temperatures &amp;gt;500 °C and large NH3 doses. On the other hand, plasma-assisted SiNx ALD processes suffer from nonuniform film properties or low conformality when deposited on high-aspect-ratio nanostructures. In the SiNx section, the authors provide a broad overview of the currently known thermal and plasma-assisted SiNx ALD processes using chlorosilane, trisilylamine, and aminosilane precursors, describe the process shortcomings, and review the literature on precursor reaction pathways. The authors close this section with suggestions for improving the film properties and conformality. In the case of SiC, the authors first outline the limitations of previously reported SiC ALD processes and highlight that unlike SiO2 and SiNx plasma-assisted ALD, no straightforward pathway for low-temperature plasma-assisted growth is currently apparent. The authors speculate that low-temperature ALD of SiC may require the design of completely new precursors. Finally, they summarize the progress made in the ALD of C-containing SiNx and SiO2 films, which may provide many of the benefits of SiC ALD in semiconductor manufacturing. In closing, through this review, the authors hope to provide the readers with a comprehensive knowledge of the surface reactions mechanisms during ALD of Si-based dielectrics, which would provide a foundation for future precursor and process development.
Quasi-triply-degenerate states and zero refractive index in two-dimensional all-dielectric photonic crystals (2019)

We introduce the concept of a quasi-triply-degenerate state (QTDS) and demonstrate its relation to an effective zero refractive index (ZRI) in a two-dimensional (2D) square lattice photonic crystal (PC) of all dielectric pillars. A QTDS is characterized by a triple band structure (TBS), wherein two of the bands manifest a linear dispersion around the Γ-point, i.e. a Dirac-like cone, while the third is a flat zero refractive index (ZRI) band with a frequency that is degenerate with one of the other bands. Significantly, we find that while triple degeneracy of the bands is not observed, the three bands approach one another so close that the observable properties of PCs adapted to the QTDS frequency perform as expected of a ZRI material. We closely examine the ZRI band at the Γ-point and show that by varying the PC material and structure parameters, the ZRI band behavior extends over a wide range of dielectric refractive indices enabling materials made with polymeric constituents. Moreover, the ZRI characteristics are robust and tolerant over a range of frequencies. Furthermore, the computational screening we employ to identify QTDS parameters enables the rational design of low-loss 2D ZRI materials for a broad range of photonic applications, including distributing a common reference phase, cloaking and focusing light.
Improved Enantiospecific RP-HPLC Assays for Propranolol in Plasma and Urine with Pronethalol as Internal Standard (1991)

For the enantiospecific assay of propranolol in biological material, formation of diastereomeric derivatives is one possible approach. The aim of the present study was the development and optimization of three analytical methods based on different chiral reagents: phenylethylisocyanate and the acyl chloride as well as the isocyanate that are derived from the fluorescent S-flunoxaprofen. Pronethalol is used as internal standard in all three procedures and improves the coefficients of variation significantly. After extraction from human plasma or urine, propranolol is reacted with one of these compounds in anhydrous organic solvents with addition of triethylamine. The diastereomeric derivatives are then resolved on an octadecylsilane column using mixtures of water and methanol with or without addition of glacial acetic acid. Good resolutions of the diastereomeric derivatives are found under these conditions. Conjugates are cleaved prior to analysis using beta-glucuronidase-arylsulfatase and assayed as parent propranolol enantiomers. All three procedures were suitable for analysis of propranolol enantiomers in biological samples in the lower nanogram range (1-2 ng/mL). A preliminary clinical study confirmed the known enantiospecificity in the pharmacokinetics of propranolol and showed high concentrations of conjugates with R/S ratios that were similar to those of the parent enantiomers.
Selection of Resistance-Conferring Mutations in HIV-1 by the Nucleoside Reverse Transcriptase Inhibitors (+/-)dOTC and (+/-)dOTFC (2000)

The patterns of resistance-conferring mutations that are selected in HIV-1 reverse transcriptase (RT) by the racemates of 2'-dideoxy-3'-oxa-4'-thiocytidine (+/-)dOTC and its fluorinated derivative (+/-)dOTFC were characterized. Genotypic and phenotypic analyses of HIV-1 clinical isolates and HXB2D variants selected with (+/-)dOTC and (+/-)dOTFC were performed in primary cells and in the MT-2 T cell line. HIV-1 variants selected with (+/-)dOTC or (+/-)dOTFC displayed fivefold decreased susceptibility to the respective compounds. A substitution of methionine to valine was identified at position 184 (M184V) in variants selected with (+/-)dOTC. In contrast, a mutation of lysine to arginine at position 65 (K65R) was found in variants selected with (+/-)dOTFC. These patterns of selected mutations differ from those seen with the individual enantiomers. Studies with mutated recombinant HXB2D-M184V and -K65R confirmed that these mutations are important for phenotypic resistance in MT-2 cells. Clinical isolates that display resistance to (-)2'-deoxy-3'-thiacytidine (3TC) also showed cross-resistance to (+/-)dOTC and (+/-)dOTFC. These studies demonstrate that similar genotypes may be selected by the dOTC and dOTFC compounds to those with the structurally related drug 3TC.
The authors reply (2014)

Ranucci, Marco MD, FESC; Castelvecchio, Serenella MD, FESC; Biondi, Andrea MD; de Vincentiis, Carlo MD; Ballotta, Andrea MD, FESC; Varrica, Alessandro MD; Frigiola, Alessandro MD; Menicanti, Lorenzo MD Author Information
Recombinant Protein Stabilization through Engineered Metal-Chelating Sites (1993)

Simple metal-chelating sites incorporated into common elements of secondary structure located on a protein surface offer a powerful and general strategy for stabilizing recombinant proteins. By binding with higher affinity to the native state of the protein, a metal ion can shift the folding/unfolding equilibrium toward the native state. To demonstrate this approach, we have engineered metal-chelating sites consisting of pairs of histidine residues into Saccharomyces cerevisiae iso-1-cytochrome c. 1 mM Cu(II) complexed to iminodiacetate stabilizes the cytochrome c variants by 1-2 kcal/mol, as determined by guanidinium chloride-induced unfolding. The increase in the free energy for unfolding is equal to that calculated from the preferential binding of the metal ion to the native protein. The Cu(II) affinities of di-histidine sites introduced in α-helices of bovine somatotropin indicate a potential for increasing stability by as much as 3.5 kcal/mol with a single di-histidine site. Chelating sites are easily introduced into surface α-helices and β-sheets while introducing minimal or no disruption of the native structure or biological function.
Health Monitoring and Life Prediction of Thermal Barrier Coatings Using a Laser-Based Method (2005)

Thermal barrier coatings (TBCs) are a critical component in low-emission gas turbines. A reliable method is required to monitor the condition of the TBC and predict coating failure. The condition of the interface between the metallic bond coat and TBC has been shown to be a potential indicator of spallation. The TBC is optically translucent; therefore, the bond coat/TBC interface can be probed using laser light with a wavelength of 0.632 microns or higher. A laser system in an optical backscatter configuration has been used to investigate several yttria-stabilized zirconia (YSZ) TBCs applied with either electron-beam physical vapor deposition (EB-PVD) or air plasma spraying (APS). The TBCs were thermally cycled for one hour increments until failure and investigated by the laser backscatter method after set numbers of thermal cycles. Correlations have been established between laser backscatter data and the number of thermal cycles, suggesting that the laser backscatter method can be used to predict failure. A theoretical model has been used to compare interface topography scatter to experimental results. This paper will discuss the laser backscatter technique and the experimental results and will compare the experimental data and theoretical scatter.
Prophylactic Antipropagation Stitch in Total Knee Arthroplasty Performed via Medial Parapatellar Approach: A Simple and Cost-Effective Technique for Reducing Quadriceps Injury (2013)

This article describes a novel, simple, and effective technique for limiting extensor mechanism damage during total knee arthroplasty (TKA) performed via the medial parapatellar (MPP) approach. Immediately on making the quadriceps tendon split in the MPP approach, a figure-of-eight stitch is placed at the apex of the split. The prophylactic stitch technique has been used by one surgeon in 1000 consecutive TKAs over the past 5 years. This technique has eliminated proximal extension of the quadriceps tendon split into the muscle belly and may help to decrease postoperative pain, increase postoperative quadriceps strength, and improve patient satisfaction and outcomes.
Long-term Rescue of Photoreceptors in a Rodent Model of Retinitis Pigmentosa Associated with MERTK Mutation (2018)

MERTK mutation reduces the ability of retinal pigment epithelial (RPE) cells to phagocytize the photoreceptor outer segments, which leads to accumulation of debris separating photoreceptors from RPE cells, resulting in their degeneration and loss of vision. In a rat model of Retinitis Pigmentosa due to MERTK mutation, we demonstrate that surgical removal of debris performed when about half of photoreceptors are lost (P38), allows the remaining photoreceptor cells to renew their outer segments and survive for at least 6 months - 3 times longer than in untreated eyes. In another set of experiments, patterned laser photocoagulation was performed before the debris formation (P19-25) to destroy a fraction of photoreceptors and thereby reduce the phagocytic load of shed outer segment fragments. This treatment also delayed the degeneration of the remaining photoreceptors. Both approaches were assessed functionally and morphologically, using electroretinography, optical coherence tomography, and histology. The long-term preservation of photoreceptors we observed indicates that MERTK-related form of inherited retinal degeneration, which has currently no cure, could be amenable to laser therapy or subretinal surgery, to extend the visual function, potentially for life.
Simulation in coronary artery anastomosis early in cardiothoracic surgical residency training: The Boot Camp experience (2021)

Objective—We evaluated focused training in coronary artery anastomosis with a porcine heart model and portable task station. Methods—At “Boot Camp,” 33 first-year cardiothoracic surgical residents participated in 4-hour coronary anastomosis sessions (6–7 attending surgeons per group of 8–9 residents). At beginning, midpoint, and session end, anastomosis components were assessed on a 3-point rating scale (1 good, 2 average, 3 below average). Performances were video recorded and reviewed by 3 surgeons in a blinded fashion. Participants completed questionnaires at session end, with follow-up surveys at 6 months. Results—Ten to 18 end-to-side anastomoses with porcine model and task station were performed. Initial assessments ranged from 2.11 ± 0.58 (forceps use) to 2.44 ± 0.48 (needle angles). Midpoint scores ranged from 1.76 ± 0.63 (forceps use) to 1.91 ± 0.49 (needle angles). Session end scores ranged from 1.29 ± 0.45 (needle holder use) to 1.58 ± 0.50 (needle transfer and suture management and tension; P < .001). Video recordings confirmed improved performance (interrater reliability > 0.5). All respondents agreed that task station and porcine model were good methods of training. At 6 months, respondents noted that the anastomosis session provided a basis for training; however, only slightly more than half continued to practice outside the operating room. Conclusions—Four-hour focused training with porcine model and task station resulted in improved ability to perform anastomoses. Boot Camp may be useful in preparing residents for coronary anastomosis in the clinical setting, but emphasis on simulation development and deliberate practice is necessary.
Waveguiding in planar photonic crystals (2000)

Photonic crystal planar circuits designed and fabricated in silicon on silicon dioxide are demonstrated. Our structures are based on two-dimensional confinement by photonic crystals in the plane of propagation, and total internal reflection to achieve confinement in the third dimension. These circuits are shown to guide light at 1550 nm around sharp corners where the radius of curvature is similar to the wavelength of light.
Conductivity Measurements of Femtosecond Laser–Plasma Filaments (2007)

Experiments are performed to characterize the electrical properties of plasma filaments that are generated by self- guided femtosecond laser pulses propagating in air. A single plasma filament passes through a high-voltage sphere pulsed at -100 kV to a grounded electrode, which serves as a current monitor. The experiments utilize moderate electric fields to probe the filament conductivity, thereby avoiding the strong perturbations caused by electric discharges. The measured filament current decreases as ~1/R <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> as the separation R between the electrodes is increased up to 1.5 m. The pulselength of the filament current signal is 2 ns (full-width at half-maximum), but the time resolution is limited by the bandwidth of the oscilloscope. The typical plasma density in the conducting filament is 9 times 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">15</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> , which is inferred from the conductivity measurements and the size of the optical filaments. Comparisons are made with mobility values derived from electron swarm data, where the mobility depends upon the applied electric field. The conductivity of the filament is measured as the laser pulselength is varied from 50 fs to 1.5 ps. We find that relatively long laser pulses (1 ps) produce filaments with the largest conductivity. A model is used to predict the longitudinal position where the plasma filament forms and is in reasonably good agreement with measurements.
Old English Philology (2016)

Robert D. Fulk is arguably the greatest Old English philologist to emerge during the twentieth century; his corpus of scholarship has fundamentally shaped contemporary understanding of many aspects of Anglo-Saxon literary history and English historical linguistics.&lt;BR&gt; This volume, in his honour, brings together essays which engage with his work and advance his research interests. Scholarship onhistorical metrics and the dating, editing, and interpretation of Old English poetry thus forms the core of this book; other topics addressed include syntax, phonology, etymology, lexicology, and paleography. An introductory overview of Professor Fulk's achievements puts these studies in context, alongside essays which assess his contributions to metrical theory and his profound impact on the study of &lt;I&gt;Beowulf&lt;/I&gt;. By consolidating and augmenting Fulk's research, this collection takes readers to the cutting edge of Old English philology. &lt;BR&gt;&lt;BR&gt; Leonard Neidorf is a Junior Fellow at theHarvard Society of Fellows; Rafael J. Pascual is a Postdoctoral Research Fellow at Harvard University; Tom Shippey is Professor Emeritus at St Louis University.&lt;BR&gt;&lt;BR&gt; Contributors: Thomas Cable,Christopher M. Cain, George Clark, Dennis Cronan, Daniel Donoghue, Aaron Ecay, Mark Griffith, Megan E. Hartman, Stefan Jurasinski, Anatoly Liberman, Donka Minkova, Haruko Momma, Rory Naismith, LeonardNeidorf, Andy Orchard, Rafael J. Pascual, Susan Pintzuk, Geoffrey Russom, Tom Shippey, Jun Terasawa, Charles D. Wright.
Varus Tibial Joint Line Obliquity (2001)

In 60 consecutive total knee arthroplasties done in 52 patients with primary osteoarthritis and varus or neutral tibiofemoral alignment, the posterior condylar angle was calculated intraoperatively and averaged 3.98° (range, 0°–9°). Eighteen knees had a posterior condylar angle value less than 3° whereas 27 knees had a posterior condylar angle value of 5° or greater. Final rotational alignment of the femoral component was set parallel to the transepicondylar axis. Only one of these 60 knees required a lateral retinacular release for proper patellar tracking during the knee arthroplasty. When compared with three previously defined angles measured on the radiographs taken preoperatively, only the tibial plateau-tibial shaft angle values were correlated significantly with the value of the posterior condylar angle. As the tibial varus joint line obliquity increased, there was a distinct tendency for the transepicondylar axis to be rotated more externally relative to the posterior condylar axis. This variance suggests that the use of the posterior condylar axis as a rotational reference is inappropriate in many knees with arthritis with varus or neutral tibiofemoral alignment. In particular, varus tibial joint line obliquity of more than 4° increases the likelihood of femoral component malrotation when the posterior femoral condyles are used to reference femoral component rotation.
ChemInform Abstract: Synthesis of Bis(1,3‐dihydroxy‐isopropyl)amine by Reductive Amination of Dihydroxyacetone: Open Chain Equivalent of DMDP and a Potential AB4 Dendritic Monomer. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Postentry Processing of Recombinant Adeno-Associated Virus Type 1 and Transduction of the Ferret Lung Are Altered by a Factor in Airway Secretions (2013)

We recently created a cystic fibrosis ferret model that acquires neonatal lung infection. To develop lung gene therapies for this model, we evaluated recombinant adeno-associated virus (rAAV)-mediated gene transfer to the neonatal ferret lung. Unlike in vitro ferret airway epithelial (FAE) cells, in vivo infection of the ferret lung with rAAV1 required proteasome inhibitors to achieve efficient airway transduction. We hypothesized that differences in transduction between these two systems were because of an in vivo secreted factor that alter the transduction biology of rAAV1. Indeed, treatment of rAAV1 with ferret airway secretory fluid (ASF) strongly inhibited rAAV1, but not rAAV2, transduction of primary FAE and HeLa cells. Properties of the ASF inhibitory factor included a strong affinity for the AAV1 capsid, heat-stability, negative charge, and sensitivity to endoproteinase Glu-C. ASF-treated rAAV1 dramatically inhibited apical transduction of FAE ALI cultures (512-fold), while only reducing viral entry by 55-fold, suggesting that postentry processing of virus was influenced by the inhibitor factor. Proteasome inhibitors rescued transduction in the presence of ASF (~1600-fold) without effecting virus internalization, while proteasome inhibitors only enhanced transduction 45-fold in the absence of ASF. These findings demonstrate that a factor in lung secretions can influence intracellular processing of rAAV1 in a proteasome-dependent fashion.
Mapping of DBR1 and YPK1 suggests a major revision of the genetic map of the left arm of Saccharomyces cerevisiae Chromosome XI. (1994)

The Saccharomyces cerevisiae dbr1 mutation has been mapped on the left arm of chromosome XI. XIL is a chromosome arm that was until now rather sparsely populated with accurately mapped markers. On the basis of physical data, the overall order of markers is inverted relative to the existing genetic map of XI. We present tetrad analyses using a variety of markers on XI that indicate that the existing genetic map of XIL should be inverted, at least for the strains in which our mapping was carried out, and probably for other S. cerevisiae strains.