gebhart/patrepeval huggingface dataset:
Edible Green Solvent for Optimized Catechins Extraction from Green Tea Leaves: Anti-Hypercholesterolemia (2022)

Catechin polyphenols are the major bioactive ingredients in green tea with various human health benefits. Extraction of catechins from green tea (GTE) leaves at optimized standard conditions is still a challenging approach. An optimized, rapid, and economic extraction method is industrially needed. We hypothesized that certain extraction techniques in the presence of natural polymers and antioxidants might improve GTE catechin extraction yield and its biological activity. The effect of microwave (30-60 seconds irradiation in a typical kitchen microwave) assisted extraction (MAE) and ultrasonic assisted extraction (UAE) techniques were evaluated separately and in combination. To study the effect of the extraction solvent, nine edible green solvent combinations were investigated namely water, ascorbic acid, chitosan/ascorbic acid, carboxymethylcellulose /ascorbic acid, methylcellulose /ascorbic acid, chitosan/methylcellulose/ascorbic acid, methylcellulose, chitosan/acetic acid, and ethanol. The amounts of extracted catechins from green tea leaves were quantified with HPLC-UV. Data showed that the use of MAE & UAE technique was the optimal in producing a higher extraction yield of catechins. Chitosan/ascorbic acid was the optimized solvent with high extraction efficiencies of catechins. Studies in high fat diet fed animals demonstrated significant reduction of total cholesterol and LDL-C by GTE after 3 weeks of oral daily administration. In conclusion, efficient extraction, and stabilization of catechins from green tea leaves demonstrated a significant lowering of high fat diet-mediated elevation in blood cholesterol and LDL-C levels.
A Dynamic Parameter Estimation Experiment That Is Remotely Accessible Via Internet (2020)

A dynamic parameter estimation experiment for first-order systems is described. A novel feature of the experiment is its accessibility y for remote execution via the Internet. The concept of a remotely shared laboratory has been proposed as a way to use readily available communication facilities to share expensive laboratory facilities among several universities. The dynamic parameter estimation experiment described here is a prototype of remotely shared laboratory exercises that are safe and inexpensive.
Block copolymer line roughness measurements via PSD: application to fingerprint samples (2020)

This paper introduces line roughness characterization non-straight patterns made of block copolymers (fingerprint patterns). Line Width Roughness have been determined using Power Spectral Density based on a special edge detection developed at CEA-LETI to extract edges contours. We investigated several process parameters impact on LWR such as the degree of polymerization of different BCPs and the impact of UV irradiation on the roughness of the PS block.
Data from <i>KRAS</i><sup>G12C</sup> Mutation Is Associated with Increased Risk of Recurrence in Surgically Resected Lung Adenocarcinoma (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;&lt;i&gt;KRAS&lt;/i&gt;&lt;sup&gt;G12C&lt;/sup&gt; is the most common &lt;i&gt;KRAS&lt;/i&gt; mutation in primary lung adenocarcinoma. Phase I clinical trials have demonstrated encouraging clinical activity of &lt;i&gt;KRAS&lt;/i&gt;&lt;sup&gt;G12C&lt;/sup&gt; inhibitors in the metastatic setting. We investigated disease-free survival (DFS) and tumor genomic features in patients with surgically resected &lt;i&gt;KRAS&lt;/i&gt;&lt;sup&gt;G12C&lt;/sup&gt;-mutant lung adenocarcinoma.&lt;/p&gt;Experimental Design:&lt;p&gt;Patients who underwent resection of stage I–III lung adenocarcinoma and next-generation sequencing (NGS) were evaluated. Exclusion criteria were receipt of induction therapy, incomplete resection, and low-quality NGS. Mutations were classified as &lt;i&gt;KRAS&lt;/i&gt; wild-type (&lt;i&gt;KRAS&lt;/i&gt;&lt;sup&gt;wt&lt;/sup&gt;), G12C (&lt;i&gt;KRAS&lt;/i&gt;&lt;sup&gt;G12C&lt;/sup&gt;), or non-G12C (&lt;i&gt;KRAS&lt;/i&gt;&lt;sup&gt;other&lt;/sup&gt;). DFS was compared between groups using the log-rank test; factors associated with DFS were assessed using Cox regression. Mutual exclusivity and cooccurrence, tumor clonality, and mutational signatures were assessed.&lt;/p&gt;Results:&lt;p&gt;In total, 604 patients were included: 374 &lt;i&gt;KRAS&lt;/i&gt;&lt;sup&gt;wt&lt;/sup&gt; (62%), 95 &lt;i&gt;KRAS&lt;/i&gt;&lt;sup&gt;G12C&lt;/sup&gt; (16%), and 135 &lt;i&gt;KRAS&lt;/i&gt;&lt;sup&gt;other&lt;/sup&gt; (22%). Three-year DFS was not different between &lt;i&gt;KRAS&lt;/i&gt;-mutant and &lt;i&gt;KRAS&lt;/i&gt;&lt;sup&gt;wt&lt;/sup&gt; tumors. However, 3-year DFS was worse in patients with &lt;i&gt;KRAS&lt;/i&gt;&lt;sup&gt;G12C&lt;/sup&gt; than &lt;i&gt;KRAS&lt;/i&gt;&lt;sup&gt;other&lt;/sup&gt; tumors (log-rank &lt;i&gt;P&lt;/i&gt; = 0.029). &lt;i&gt;KRAS&lt;/i&gt;&lt;sup&gt;G12C&lt;/sup&gt; tumors had more lymphovascular invasion (51% vs. 37%; &lt;i&gt;P&lt;/i&gt; = 0.032) and higher tumor mutation burden [median (interquartile range), 7.0 (5.3–10.8) vs. 6.1 (3.5–9.7); &lt;i&gt;P&lt;/i&gt; = 0.021], compared with &lt;i&gt;KRAS&lt;/i&gt;&lt;sup&gt;other&lt;/sup&gt; tumors. &lt;i&gt;KRAS&lt;/i&gt;&lt;sup&gt;G12C&lt;/sup&gt; mutation was independently associated with worse DFS on multivariable analysis. Our DFS findings were externally validated in an independent The Cancer Genome Atlas cohort.&lt;/p&gt;Conclusions:&lt;p&gt;&lt;i&gt;KRAS&lt;/i&gt;&lt;sup&gt;G12C&lt;/sup&gt; mutations are associated with worse DFS after complete resection of stage I–III lung adenocarcinoma. These tumors harbor more aggressive clinicopathologic and genomic features than other &lt;i&gt;KRAS&lt;/i&gt;-mutant tumors. We identified a high-risk group for whom &lt;i&gt;KRAS&lt;/i&gt;&lt;sup&gt;G12C&lt;/sup&gt; inhibitors may be investigated to improve survival.&lt;/p&gt;&lt;/div&gt;
Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity (2021)

Chordomas are rare spinal tumors addicted to expression of the developmental transcription factor brachyury. In chordomas, brachyury is super-enhancer associated and preferentially downregulated by pharmacologic transcriptional CDK inhibition, leading to cell death. To understand the underlying basis of this sensitivity, we dissect the brachyury transcription regulatory network and compare the consequences of brachyury degradation with transcriptional CDK inhibition. Brachyury defines the chordoma super-enhancer landscape and autoregulates through binding its super-enhancer, and its locus forms a transcriptional condensate. Transcriptional CDK inhibition and brachyury degradation disrupt brachyury autoregulation, leading to loss of its transcriptional condensate and transcriptional program. Compared with transcriptional CDK inhibition, which globally downregulates transcription, leading to cell death, brachyury degradation is much <b>more selective, inducing senescence and sensitizing cells</b> to anti-apoptotic inhibition. These data suggest that brachyury downregulation is a core tenet of transcriptional CDK inhibition and motivates developing strategies to target brachyury and its autoregulatory feedback loop.
A Reexamination of the Mouse Embryonic Radiation Cataract Studies (1971)

In repeating the procedures for radiation-induced cataracts in mouse embryos, as reported in 1964, we were unable to achieve the same conclusions. We cannot explain the disparities but feel obligat...
A study of the incidence of epilepsy following ECT (1980)

In a group of 166 patients who had received electroconvulsive therapy more than one year previously the prevalence of epilepsy did not differ significantly from that found in the community as a whole. The findings suggest that a kindling process is not a clinical hazard following repeated electrically induced seizures.
Randomized query processing in robot path planning (1995)

Article Randomized query processing in robot path planning Share on Authors: Lydia E. Kavraki Robotics Laboratory, Department of Computer Science, Stanford University, Stanford, CA Robotics Laboratory, Department of Computer Science, Stanford University, Stanford, CAView Profile , Jean-Claude Latombe Robotics Laboratory, Department of Computer Science, Stanford University, Stanford, CA Robotics Laboratory, Department of Computer Science, Stanford University, Stanford, CAView Profile , Rajeev Motwani Department of Computer Science, Stanford University, Stanford, CA Department of Computer Science, Stanford University, Stanford, CAView Profile , Prabhakar Raghavan IBM Research Division, T.J. Watson Research Center, Yorktown Heights, NY IBM Research Division, T.J. Watson Research Center, Yorktown Heights, NYView Profile Authors Info & Claims STOC '95: Proceedings of the twenty-seventh annual ACM symposium on Theory of computingMay 1995 Pages 353–362https://doi.org/10.1145/225058.225159Online:29 May 1995Publication History 43citation523DownloadsMetricsTotal Citations43Total Downloads523Last 12 Months12Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
A Unified Compact model for FinFET and Silicon Nanowire MOSFETs (2009)

A unified compact model for FinFET and siliconnanowire MOSFETs including all major short-channel effects is presented. The source–drain symmetry, which is a fundamental feature of an ideal MOSFET, is preserved. The unified compact model is validated with experimental data including higher-order derivatives of
Effect of gamut shape on colour preference (2016)

A psychophysical experiment was conducted to investigate the colour preference of various objects placed in viewing booth, arranged to mimic a typical restaurant setting, under pairs of light settings. Two sets of spectral power distributions (SPDs), with five SPDs in each, had similar relative-gamut indices of 121 and 111, respectively, but different gamut shapes, shape of the polygon created from the chromaticities of colour samples of the average chromaticities in each hue angle bin in a colour space. The systematic variation in gamut shapes created different colour shifts for different objects, leading to different preferences. The colour shifts of familiar objects created by these stimuli were especially important to judgments of overall colour preference. A supplementary colour vector graphic illustrating shifts in hue and chromacan convey additional importtant information about colour rendition, complementing colour fidelity and relative-gamut indices.
ChemInform Abstract: Discovery of Lu AA33810: A Highly and Potent NPY5 Antagonist with in vivo Efficacy in a Model of Mood Disorder. (2011)

Abstract Template hopping and optimization of neuropeptide Y5 leads results in the discovery of Lu AA33810 (I), which demonstrates a good pharmacokinetic profile with acceptable CNS exposure.
Channel-coded Collision Resolution by Exploiting Symbol Misalignment (2010)

In random-access networks, such as the IEEE 802.11 network, different users may transmit their packets simultaneously, resulting in packet collisions. Traditionally, the collided packets are simply discarded. To improve performance, advanced signal processing techniques can be applied to extract the individual packets from the collided signals. Prior work of ours has shown that the symbol misalignment among the collided packets can be exploited to improve the likelihood of successfully extracting the individual packets. However, the failure rate is still unacceptably high. This paper investigates how channel coding can be used to reduce the failure rate. We propose and investigate a decoding scheme that incorporates the exploitation of the aforementioned symbol misalignment into the channel decoding process. This is a fine-grained integration at the symbol level. In particular, collision resolution and channel decoding are applied in an integrated manner. Simulation results indicate that our method outperforms other schemes, including the straightforward method in which collision resolution and channel coding are applied separately.
Y1−xLaxVO3: Effects of doping on orbital ordering (2014)

The effects of isovalent doping on orbital ordering in the perovskite ${\mathrm{Y}}_{1\ensuremath{-}x}{\mathrm{La}}_{x}{\mathrm{VO}}_{3}$ were investigated using neutron diffraction and the pair distribution function analysis. ${\mathrm{YVO}}_{3}$ is a prototype for orbital ordering, exhibiting two consecutive transitions to G-type and C-type ordering with decreasing temperature. Evidence for local orbital ordering above the transition temperature of ${T}_{OO}\ensuremath{\sim}200$ K is presented, obtained from the temperature dependence of the oxygen-oxygen octahedral correlations. This suggests that locally, G-type orbital ordering is present above the ${T}_{OO}$ temperature but it is short range. With doping, it is expected that orbital ordering disappears altogether. By 30% of doping, as in ${\mathrm{Y}}_{0.7}{\mathrm{La}}_{0.3}{\mathrm{VO}}_{3}$, even though no orbital ordering is expected, we find that locally, C-type orbital correlations are most likely present below the magnetic transition temperature ${T}_{N}$, allowing for a direct paramagnetic to orbitally ordered/antiferromagnetic transition in this composition.
Combinatorial Approaches (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
A Model-Based Visualization Taxonomy (2002)

Most flax (Linum usitatissimum) varieties are described as tolerant to high concentrations of Cd. The aim of the present paper was to better characterize this tolerance, by studying the responses of flax plantlets, cv Hermes, to 18d growth on 0.5mM Cd. In Cd-treated seedlings, the majority of Cd was compartmentalized in the roots. Analysis of other elements showed that only Fe concentration was reduced, while Mn increased. Growth parameters of Cd treated flax were only moderately altered, with similar mass tolerance-indices for roots and shoots. Tissue anatomy was unaffected by treatment. The effect on lipid peroxidation, protein carbonylation and antioxidative activities appeared low but slightly higher in roots. The most important impacts of Cd were, in all organs, cell expansion, cell-wall thickening, pectin cross-linking and increase of cell-wall enzymatic activities (pectin methylesterase and peroxidase). Thus, the role of the cell wall in Cd tolerance might be important at two levels: (i) in the reinforcement of the tissue cohesion and (ii) in the sequestration of Cd.
The Effect of Wastewater Cations on Activated Sludge Characteristics: Effects of Aluminum and Iron in Floc (2006)

Wastewater samples collected from seven wastewater treatment plants (WWTPs) were characterized to assess the impacts of wastewater cations on the activated sludge process. The cations included in this study were sodium (Na+), potassium, ammonium, calcium, magnesium, aluminum (Al), and iron (Fe). Among the selected cations, Al and Fe were of most interest to this study because their role in bioflocculation has not been extensively studied and remains largely unknown. The data showed that WWTPs contained highly varying concentrations of Na+, Al, and Fe in the wastewater and that these cations were responsible for differences between WWTPs as to sludge dewatering rates and effluent quality. In general, a high influent Na+ concentration caused poor sludge dewatering and effluent characteristics. However, when sufficient Al and Fe were present in floc, the deleterious effects of Na+ were offset. The data associated with Al further revealed that waste activated sludge with low Al contained high concentrations of soluble and colloidal biopolymer (protein + polysaccharide), resulting in a high effluent chemical oxygen demand, high conditioning chemical requirements, and poor sludge dewatering properties. These results suggest that Al will improve activated sludge effluent quality by scavenging organic compounds from solution and binding them to floc.
Parallel generation and coding of a terahertz pulse train (2022)

The generation and coding of multi-cycle terahertz (THz) pulses offer interesting possibilities, such as frequency comb spectroscopy or ultra-fast packet communication. In contrast to the radio frequency domain, which has largely exploited packet communication, this research area is almost unexplored at THz frequencies. Indeed, because of the lack of fast modulation and detection methods at THz frequencies, current developments often rely on hybrid techniques mixing photonics and ultrafast electronics. Here, we present a method for the generation and modulation of a coded THz pulse train. Our scheme is based on the combination of a spintronic THz emitter (STE) with an echelon mirror and a digital micromirror device. This highly scalable configuration is capable of modulating a hundred or more THz pulses in parallel with sub-picosecond accuracy. Strikingly, the temporal resolution of our modulation scheme depends on geometric optics and not on a high-speed electronic device. Furthermore, our scheme confirms the ability of STEs to generate quasi-continuous THz pulses and offers a new photonic solution on dynamic THz pulse train control.
Intramolecular substitutions of secondary and tertiary alcohols with chirality transfer by an iron(III) catalyst (2019)

Optically pure alcohols are abundant in nature and attractive as feedstock for organic synthesis but challenging for further transformation using atom efficient and sustainable methodologies, particularly when there is a desire to conserve the chirality. Usually, substitution of the OH group of stereogenic alcohols with conservation of chirality requires derivatization as part of a complex, stoichiometric procedure. We herein demonstrate that a simple, inexpensive, and environmentally benign iron(III) catalyst promotes the direct intramolecular substitution of enantiomerically enriched secondary and tertiary alcohols with O-, N-, and S-centered nucleophiles to generate valuable 5-membered, 6-membered and aryl-fused 6-membered heterocyclic compounds with chirality transfer and water as the only byproduct. The power of the methodology is demonstrated in the total synthesis of (+)-lentiginosine from D-glucose where iron-catalysis is used in a key step. Adoption of this methodology will contribute towards the transition to sustainable and bio-based processes in the pharmaceutical and agrochemical industries.
Data from Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody–Drug Conjugates (2023)

&lt;div&gt;Abstract&lt;p&gt;Antibody–drug conjugates (ADC) are designed to selectively bind to tumor antigens via the antibody and release their cytotoxic payload upon internalization. Controllable payload release through judicious design of the linker has been an early technological milestone. Here, we examine the effect of the protease-cleavable valine-citrulline [VC(S)] linker on ADC efficacy. The VC(S) linker was designed to be cleaved by cathepsin B, a lysosomal cysteine protease. Surprisingly, suppression of cathepsin B expression via CRISPR-Cas9 gene deletion or shRNA knockdown had no effect on the efficacy of ADCs with VC(S) linkers armed with a monomethyl auristatin E (MMAE) payload. Mass spectrometry studies of payload release suggested that other cysteine cathepsins can cleave the VC(S) linker. Also, ADCs with a nonprotease-cleavable enantiomer, the VC(R) isomer, mediated effective cell killing with a cysteine-VC(R)-MMAE catabolite generated by lysosomal catabolism. Based on these observations, we altered the payload to a pyrrolo[2,1-c][1,4]benzodiazepine dimer (PBD) conjugate that requires linker cleavage in order to bind its DNA target. Unlike the VC-MMAE ADCs, the VC(S)-PBD ADC is at least 20-fold more cytotoxic than the VC(R)-PBD ADC. Our findings reveal that the VC(S) linker has multiple paths to produce active catabolites and that antibody and intracellular targets are more critical to ADC efficacy. These results suggest that protease-cleavable linkers are unlikely to increase the therapeutic index of ADCs and that resistance based on linker processing is improbable. &lt;i&gt;Cancer Res; 77(24); 7027–37. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Identification of MCL1 as a novel target in neoplastic mast cells in systemic mastocytosis: inhibition of mast cell survival by MCL1 antisense oligonucleotides and synergism with PKC412 (2006)

MCL-1 is a Bcl-2 family member that has been described as antiapoptotic in various myeloid neoplasms. Therefore, MCL-1 has been suggested as a potential new therapeutic target. Systemic mastocytosis (SM) is a myeloid neoplasm involving mast cells (MCs) and their progenitors. In the present study, we examined the expression and functional role of MCL-1 in neoplastic MCs and sought to determine whether MCL-1 could serve as a target in SM. As assessed by RT-PCR and immunohistochemical examination, primary neoplastic MCs expressed MCL-1 mRNA and the MCL-1 protein in all SM patients examined. Moreover, MCL-1 was detectable in both subclones of the MC line HMC-1--HMC-1.1 cells, which lack the SM-related KIT mutation D816V, and HMC-1.2 cells, which carry KIT D816V. Exposure of HMC-1.1 cells or HMC-1.2 cells to MCL-1-specific antisense oligonucleotides (ASOs) or MCL-1-specific siRNA resulted in reduced survival and increased apoptosis compared with untreated cells. Moreover, MCL-1 ASOs were found to cooperate with various tyrosine kinase inhibitors in producing growth inhibition in neoplastic MCs, with synergistic effects observed with PKC412, AMN107, and imatinib in HMC-1.1 cells and with PKC412 in HMC-1.2 cells. Together, these data show that MCL-1 is a novel survival factor and an attractive target in neoplastic MCs.
A comprehensive description of the transcriptome of the hypothalamoneurohypophyseal system in euhydrated and dehydrated rats (2006)

The hypothalamoneurohypophyseal system (HNS) consists of the large peptidergic magnocellular neurons of the supraoptic hypo thalamic nucleus (SON) and the paraventricular hypothalamic nucleus (PVN), the axons of which course through the internal zone of the median eminence and terminate at blood capillaries of the posterior lobe of the pituitary gland. The HNS is a specialized brain neurosecretory apparatus responsible for the production of the antidiuretic peptide hormone vasopressin (VP). VP maintains water balance by promoting water conservation at the level of the kidney. Dehydration evokes a massive increase in the regulated release of VP from magnocellular neuron axon terminals in the posterior pituitary, which is accompanied by a plethora of changes in the morphology, electrophysiological properties, and biosynthetic and secretory activity of the HNS. We wish to understand this functional plasticity in terms of the differential expression of genes. We have therefore used microarrays to comprehensively catalog the genes expressed in the PVN, the SON and the neurointermediate lobe of the pituitary gland of control and dehydrated rats. Comparison of these gene lists has enabled us to identify transcripts that are regulated as a consequence of dehydration as well as RNAs that are enriched in the PVN or the SON. We suggest that these differentially expressed genes represent candidate regulators and effectors of HNS activity and remodeling.