gebhart/patrepeval huggingface dataset:
A 1.5D transducer for medical ultrasound (1994)

The current shift to digital beamforming technology holds promise for regular and rapid increases in the number of channels in a medical imager. A 1D transducer typically utilizes 125 elements, while a fully sampled two-dimensional aperture requires of order 10000 elements. Currently, channels are still expensive, so it is of interest to evaluate how much performance can be improved with a moderate increment in channel count. How may we maximize the impact on voxel size? The number of elevational elements is constrained by how complex the interconnections can become. It is impractical to significantly degrade the azimuthal resolution from the 1D case. We present beam profiles and images from a first attempt at judicious use of a 256 channel imager. Simulations and experiments allow us to explore compromises among a number of design goals. We have fabricated a transducer with several elevational rows which reduces the slice thickness of the image while maintaining full azimuthal resolution
Intracellular Staphylococcus aureus employs the cysteine protease staphopain A to induce host cell death in epithelial cells (2021)

Staphylococcus aureus is a major human pathogen, which can invade and survive in non-professional and professional phagocytes. Uptake by host cells is thought to contribute to pathogenicity and persistence of the bacterium. Upon internalization by epithelial cells, cytotoxic S. aureus strains can escape from the phagosome, replicate in the cytosol and induce host cell death. Here, we identified a staphylococcal cysteine protease to induce cell death after translocation of intracellular S. aureus into the host cell cytoplasm. We demonstrated that loss of staphopain A function leads to delayed onset of host cell death and prolonged intracellular replication of S. aureus in epithelial cells. Overexpression of staphopain A in a non-cytotoxic strain facilitated intracellular killing of the host cell even in the absence of detectable intracellular replication. Moreover, staphopain A contributed to efficient colonization of the lung in a mouse pneumonia model. In phagocytic cells, where intracellular S. aureus is exclusively localized in the phagosome, staphopain A did not contribute to cytotoxicity. Our study suggests that staphopain A is utilized by S. aureus to exit the epithelial host cell and thus contributes to tissue destruction and dissemination of infection.
Scale-dependent reproduction of pen-and-ink illustrations (1996)

This paper describes a representation for pen-and-ink illustrations that allows the creation of high-fidelity illustrations at any scale or resolution. We represent a pen-and-ink illustration as a low-resolution grey-scale image, augmented by a set of discontinuity segments, along with a stroke texture. To render an illustration at a particular scale, we first rescale the grey-scale image to the desired size and then hatch the resulting image with pen-and-ink strokes. The main technical contribution of the paper is a new reconstruction algorithm that magnifies the low-resolution image while keeping the resulting image sharp along discontinuities.
Inhibition of Synaptosomal Neurotransmitter Uptake by Hallucinogens (1983)

The effect of 13 hallucinogens on the uptake of serotonin and norepinephrine into hippocampal synaptosomes and of serotonin and dopamine into caudate synaptosomes was found to be inhibitory, except for lysergic acid diethylamide and 2-bromolysergic acid diethylamide, which were inactive. The indolealkylamines were generally more potent than the phenylethylamines. The reported inhibition of uptake of serotonin by 5-methoxy-N,N-dimethyltryptamine and lysergic acid diethylamide into whole brain synaptosomes was not reproducible at concentrations 10(2) to 10(4) times higher than those stated in the literature.
Preparation of magnetic cellulose composites using ionic liquids (2006)

Cellulose-magnetite composites have been prepared by suspension and dispersion of magnetite particles in a homogenous ionic liquid solution of cellulose, followed by regeneration into water, enabling the preparation of magnetically responsive films, flocs, fibers, or beads. The materials prepared were ferromagnetic, with a small superparamagnetic response, characteristic of the initial magnetite added. X-ray diffraction data indicated that the magnetite particles were chemically unaltered after encapsulation with an average particle size of approximately 25 nm.
ChemInform Abstract: The Synthesis of Pyrido[3,2‐a]acridines. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Fiber Bragg grating temperature sensor with controllable sensitivity (1999)

We demonstrate a fiber Bragg grating (FBG) sensor with controllable sensitivity by connecting two metal strips that have different temperature-expansion coefficients. By changing the lengths of the metal strips we successfully controlled and improved the temperature sensitivity to 3.3 times of that of bare FBG.
GPU-Initiated On-Demand High-Throughput Storage Access in the BaM System Architecture (2022)

Graphics Processing Units (GPUs) have traditionally relied on the host CPU to initiate access to the data storage. This approach is well-suited for GPU applications with known data access patterns that enable partitioning of their dataset to be processed in a pipelined fashion in the GPU. However, emerging applications such as graph and data analytics, recommender systems, or graph neural networks, require fine-grained, data-dependent access to storage. CPU initiation of storage access is unsuitable for these applications due to high CPU-GPU synchronization overheads, I/O traffic amplification, and long CPU processing latencies. GPU-initiated storage removes these overheads from the storage control path and, thus, can potentially support these applications at much higher speed. However, there is a lack of systems architecture and software stack that enable efficient GPU-initiated storage access. This work presents a novel system architecture, BaM, that fills this gap. BaM features a fine-grained software cache to coalesce data storage requests while minimizing I/O traffic amplification. This software cache communicates with the storage system via high-throughput queues that enable the massive number of concurrent threads in modern GPUs to make I/O requests at a high rate to fully utilize the storage devices and the system interconnect. Experimental results show that BaM delivers 1.0x and 1.49x end-to-end speed up for BFS and CC graph analytics benchmarks while reducing hardware costs by up to 21.7x over accessing the graph data from the host memory. Furthermore, BaM speeds up data-analytics workloads by 5.3x over CPU-initiated storage access on the same hardware.
ChemInform Abstract: SYNTHESIS OF NATURALLY OCCURRING QUINONES. PART 9. LEWIS ACID MEDIATED ALLYLATION OF 2‐ALKANOYL‐1,4‐QUINONES WITH ALLYLSILANE AND ALLYLSTANNANE (1982)

Abstract In Gegenwart von Bortrifluorid erhält man aus Acetyl‐chinon (I) mit den Allylzinnverbindungen (II) die Produkte (III), die zu den Verbindungen (IV) acetyliert werden.
Supplementary Figure 1 from An <i>In Vivo</i> Immunotherapy Screen of Costimulatory Molecules Identifies Fc-OX40L as a Potent Reagent for the Treatment of Established Murine Gliomas (2023)

&lt;p&gt;PDF file, 301K, Bioluminescence imaging to track tumor progression over time.&lt;/p&gt;
Magnetic anisotropy in permalloy: Hidden quantum mechanical features (2018)

By means of relativistic, first principles calculations, we investigate the microscopic origin of the vanishingly low magnetic anisotropy of Permalloy, here proposed to be intrinsically related to the local symmetries of the alloy. It is shown that the local magnetic anisotropy of individual atoms in Permalloy can be several orders of magnitude larger than that of the bulk sample and 5--10 times larger than that of elemental Fe or Ni. We furthermore show that locally there are several easy axis directions that are favored, depending on local composition. The results are discussed in the context of perturbation theory, applying the relation between magnetic anisotropy and orbital moment. Permalloy keeps its pronounced soft ferromagnetic nature due to the exchange energy to be larger than the magnetocrystalline anisotropy. Our results shine light on the magnetic anisotropy of permalloy and of magnetic materials in general, and in addition enhance the understanding of pump-probe measurements and ultrafast magnetization dynamics.
A practical solution to the string stability problem in autonomous vehicle following (2004)

This work describes an improved autonomous vehicle following control scheme based on inter-vehicle communication. A previously developed autonomous following algorithm uses an on-board laser scanning radar sensor (LIDAR) to measure the ego-vehicle's relative position with respect to its preceding vehicle, and the steering command is calculated for the ego-vehicle to follow the preceding vehicle. In this control scheme, the performance of the following vehicle largely depends on the behavior of the preceding vehicle. String stability becomes a serious issue when this control algorithm is applied to a platoon of vehicles. The deterioration of road tracking performance is another concern. The road tracking error of one vehicle is passed on to following vehicles, and the errors may accumulate as they propagate in the upstream direction. It is shown in the paper that inter-vehicle communication is a practical solution to this problem. Experimental and simulation results are presented.
Model-Based Detection of Hydrogen Leaks in a Fuel Cell Stack (2008)

Hydrogen leaks are potentially dangerous faults in fuel cell systems that are fed with hydrogen-rich gas mixtures. This brief presents an approach to hydrogen leak detection and, thus, complements direct detection using hydrogen sensors. It relies on simple mass balance equations of an anode filling volume after taking into account the natural leak of the stack. A hydrogen mass flow, anode pressure, and relative humidity sensor are employed. Hydrogen leak detection without the use of relative humidity sensors is considered by employing adaptive alarm thresholds to eliminate false alarms. The validity of the method is also discussed in terms of common hydrogen supply system configurations. The detection method is validated using a 1.25-kW polymer electrolyte membrane fuel cell stack in a laboratory facility where leaks could be introduced in a controlled manner.
Concepts of Sustainability in Clean Water Technologies (2022)

Water is essential for human survival. Hence, universal access to safe and affordable drinking water is included as one of the Sustainable Development Goals of the United Nations. With increasing global water stress and stricter revised regulations by bodies such as World Health Organization (WHO) and U.S. Environmental Protection Agency (USEPA) for safe drinking water, it is imperative to research efficient water treatment and quality monitoring technologies that are environmentally benign, affordable, and have ease of implementation. In this regard, sustainable nanomaterial-based technologies are capable of delivering real-time solutions cost-effectively using less energy by reducing ecological impact. These technologies are expected to play a significant role in water remediation including potable water treatment, sensing, wastewater desalination, and water harvesting. However, it is crucial to carefully assess the various sustainability criteria for diverse technologies before their large-scale implementation. In this chapter, we discuss a variety of emerging nanomaterial-based treatment and sensing techniques in the scientific literature and in the market, from the concepts of sustainability and their applications to assess clean water technologies using sustainability metrics. Bio-based processes look promising for the future of water purification in terms of effectiveness and environmental safety. Apart from current nanotechnological frontiers in diverse clean water applications, suggestions for future research are also provided.
Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group (2009)

We report gene expression and other analyses to elucidate the molecular characteristics of acute lymphoblastic leukemia (ALL) in children with Down syndrome (DS). We find that by gene expression DS-ALL is a highly heterogeneous disease not definable as a unique entity. Nevertheless, 62% (33/53) of the DS-ALL samples analyzed were characterized by high expression of the type I cytokine receptor CRLF2 caused by either immunoglobulin heavy locus (IgH@) translocations or by interstitial deletions creating chimeric transcripts P2RY8-CRLF2. In 3 of these 33 patients, a novel activating somatic mutation, F232C in CRLF2, was identified. Consistent with our previous research, mutations in R683 of JAK2 were identified in 10 specimens (19% of the patients) and, interestingly, all 10 had high CRLF2 expression. Cytokine receptor-like factor 2 (CRLF2) and mutated Janus kinase 2 (Jak2) cooperated in conferring cytokine-independent growth to BaF3 pro-B cells. Intriguingly, the gene expression signature of DS-ALL is enriched with DNA damage and BCL6 responsive genes, suggesting the possibility of B-cell lymphocytic genomic instability. Thus, DS confers increased risk for genetically highly diverse ALLs with frequent overexpression of CRLF2, associated with activating mutations in the receptor itself or in JAK2. Our data also suggest that the majority of DS children with ALL may benefit from therapy blocking the CRLF2/JAK2 pathways.
The synthesis of perdeuterated azone (d35‐1‐dodecylhexahydro‐2H‐azepin‐2‐one) (1994)

Abstract Perdeuteroazone ( 3 ) has been synthesised via the base‐catalysed coupling of d 11 ‐hexahydro‐2 H ‐azepin‐2‐one ( 2 ) with d 25 ‐1‐chlorododecane.
EFFECT OF WRIST AND FOREARM TRAINING ON LINEAR BAT-END,CENTER OF PERCUSSION, AND HAND VELOCITIES AND ON TIME TO BALL CONTACT OF HIGH SCHOOL BASEBALL PLAYERS (2006)

This study examined the effects of 12 weeks of wrist and forearm training on linear bat-end velocity (BV), center of percussion velocity (CV), hand velocity (HV), and time to ball contact of high school baseball players. Forty-three baseball players were randomly assigned by a stratified sampling technique to 1 of 2 training groups. Group 1 (n = 23) and group 2 (n = 20) performed the same full-body resistance exercises while training 3 days a week for 12 weeks according to a stepwise periodized model. Group 2 also performed wrist and forearm exercises 3 days a week for 12 weeks. Wrist and forearm strength were measured pre- and posttraining. Linear BV, CV, HV, and time to ball contact were recorded pre- and posttraining by a motion-capture system. A 3 repetition maximum (RM) parallel squat and bench press were measured at baseline and after 4, 8, and 12 weeks of training. Both groups showed statistically significant increases (p ≤ 0.01) in linear BV, CV, and HV (m·s−1 ± SD) after 12 weeks of training; however, there were no differences between the 2 groups. Both groups statistically increased wrist and forearm strength (p ≤ 0.05). Group 2 had statistically greater increases (p ≤ 0.05) in 10 of 12 wrist and forearm strength measures than did group 1. Both groups made statistically significant increases in predicted 1RM parallel squat and bench press after 4, 8, and 12 weeks of training; however, there were no differences between groups. These data indicate that a 12-week stepwise periodized training program can significantly increase wrist and forearm strength, linear BV, CV, and HV among high school baseball players. However, increased wrist and forearm strength did not contribute to further increases in linear BV, CV, or HV.
Lyn Physically Associates With the Erythropoietin Receptor and May Play a Role in Activation of the Stat5 Pathway (1998)

Protein tyrosine phosphorylation plays a crucial role in signaling from the receptor for erythropoietin (Epo), although the Epo receptor (EpoR) lacks the tyrosine kinase domain. We have previously shown that the Jak2 tyrosine kinase couples with the EpoR to transduce a growth signal. In the present study, we demonstrate that Lyn, a Src family tyrosine kinase, physically associates with the EpoR in Epo-dependent hematopoietic cell lines, 32D/EpoR-Wt and F36E. Coexpression experiments in COS7 cells further showed that Lyn induces tyrosine phosphorylation of the EpoR and that both LynA and LynB, alternatively spliced forms of Lyn, bind with the membrane-proximal 91-amino acid region of the EpoR cytoplasmic domain. In vitro binding studies using GST-Lyn fusion proteins further showed that the Src homology (SH)-2 domain of Lyn specifically binds with the tyrosine-phosphorylated EpoR in lysate from Epo-stimulated cells, whereas the tyrosine kinase domain of Lyn binds with the unphosphorylated EpoR. Far-Western blotting and synthetic phosphopeptide competition assays further indicated that the Lyn SH2 domain directly binds to the tyrosine-phosphorylated EpoR, most likely through its interaction with phosphorylated Y-464 or Y-479 in the carboxy-terminal region of the EpoR. In vitro binding studies also demonstrated that the Lyn SH2 domain directly binds to tyrosine-phosphorylated Jak2. In vitro reconstitution experiments in COS7 cells further showed that Lyn induces tyrosine phosphorylation of Stat5, mainly on Y-694, and activates the DNA-binding and transcription-activating abilities of Stat5. In agreement with this, Lyn enhanced the Stat5-dependent transcriptional activation when overexpressed in 32D/EpoR-Wt cells. In addition, Lyn was demonstrated to phosphorylate the EpoR and Stat5 on tyrosines in vitro. These results suggest that Lyn may play a role in activation of the Jak2/Stat5 and other signaling pathways by the EpoR.
Free mycolic acid accumulation in the cell wall of the mce1 operon mutant strain of Mycobacterium tuberculosis (2013)

The lipid-rich cell wall of Mycobacterium tuberculosis, the agent of tuberculosis, serves as an effective barrier against many chemotherapeutic agents and toxic host cell effector molecules, and it may contribute to the mechanism of persistence. Mycobacterium tuberculosis strains mutated in a 13-gene operon called mce1, which encodes a putative ABC lipid transporter, induce aberrant granulomatous response in mouse lungs. Because of the postulated role of the mce1 operon in lipid importation, we compared the cell wall lipid composition of wild type and mce1 operon mutant M. tuberculosis H37Rv strains. High resolution mass spectrometric analyses of the mce1 mutant lipid extracts showed unbound mycolic acids to accumulate in the cell wall. Quantitative analysis revealed a 10.7 fold greater amount of free mycolates in the mutant compared to that of the wild type strain. The free mycolates were comprised of alpha, methoxy and keto mycolates in the ratio 1:0.9:0.6, respectively. Since the mce1 operon is regulated in vivo, the free mycolates that accumulate during infection may serve as a barrier for M. tuberculosis against toxic products and contribute to the pathogen's persistence.
Supplementary Figure from Nonclinical Characterization of Bexmarilimab, a Clever-1–Targeting Antibody for Supporting Immune Defense Against Cancers (2023)

Supplementary Figure from Nonclinical Characterization of Bexmarilimab, a Clever-1–Targeting Antibody for Supporting Immune Defense Against Cancers
Cs$_2$InAgCl$_6$: A new lead-free halide double perovskite with direct band gap (2016)

A$_2$BB$^\prime$X$_6$ halide double perovskites based on bismuth and silver have recently been proposed as potential environmentally-friendly alternatives to lead-based hybrid halide perovskites. In particular, Cs$_2$BiAgX$_6$ (X = Cl, Br) have been synthesized and found to exhibit band gaps in the visible range. However, the band gaps of these compounds are indirect, which is not ideal for applications in thin film photovoltaics. Here, we propose a new class of halide double perovskites, where the B$^{3+}$ and B$^{+}$ cations are In$^{3+}$ and Ag$^{+}$, respectively. Our first-principles calculations indicate that the hypothetical compounds Cs$_2$InAgX$_6$ (X = Cl, Br, I) should exhibit direct band gaps between the visible (I) and the ultraviolet (Cl). Based on these predictions, we attempt to synthesize Cs$_2$InAgCl$_6$ and Cs$_2$InAgBr$_6$, and we succeed to form the hitherto unknown double perovskite Cs$_2$InAgCl$_6$. X-ray diffraction yields a double perovskite structure with space group $Fm\overline{3}m$. The measured band gap is 3.3 eV, and the compound is found to be photosensitive and turns reversibly from white to orange under ultraviolet illumination. We also perform an empirical analysis of the stability of Cs$_2$InAgX$_6$ and their mixed halides based on Goldschmidt's rules, and we find that it should also be possible to form Cs$_2$InAg(Cl$_{1-x}$Br$_{x}$)$_6$ for $x&lt;1$. The synthesis of mixed halides will open the way to the development of lead-free double perovskites with direct and tunable band gaps.
Vitamin D Regulates Human Ectocervical Epithelial Cell Proliferation and Insulin-Like Growth Factor-Binding Protein-3 Level1 (1999)

The differentiation status of the cervical epithelial cell has an important influence on responsiveness to estrogens and progestins. Several agents, including glucocorticoids and retinoids, are known to influence cervical cell differentiation. However, the effects of vitamin D have not been examined. Vitamin D is known to regulate cell proliferation and gene expression in a variety of epithelial cells. In the present study we investigated the ability of 1alpha25-dihydroxyvitamin D3 (D3) to regulate cell proliferation and expression of insulin-like growth factor-binding protein-3 (IGFBP-3) in human ectocervical epithelial cells. ECE16-1, a non-tumorigenic cervical cell line, was growth inhibited by D3 with maximal inhibition at 1000 nM. IGFBP-3 levels increased in parallel with the growth inhibition. IGFBP-3 levels were half-maximally increased at approximately 10-100 nM and maximally increased (10- to 30-fold) at 1000 nM D3. These studies show that vitamin D regulates cervical epithelial cell gene regulation and cell proliferation and that IGFBP-3 may be an in vivo marker of vitamin D action in the cervix.
Functional genomic screening to enhance oncolytic virotherapy (2012)

Functional genomic screening has emerged as a powerful approach for understanding complex biological phenomena. Of the available tools, genome-wide RNA interference (RNAi) technology is unquestionably the most incisive, as it directly probes gene function. Recent applications of RNAi screening have been impressive. Notable amongst these are its use in elucidated mechanism(s) for signal transduction, various aspects of cell biology, tumourigenesis and metastasis, resistance to cancer therapeutics, and the host's response to a pathogen. Herein we discuss how recent RNAi screening efforts have helped turn our attention to the targetability of non-oncogene support pathways for cancer treatment, with a particular focus on a recent study that identified a non-oncogene addiction to the ER stress response as a synergist target for oncolytic virus therapy (OVT). Moreover, we give our thoughts on the future of RNAi screening as a tool to enhance OVT and describe recent technical improvements that are poised to make genome-scale RNAi experiments more sensitive, less noisy, more applicable in vivo, and more easily validated in clinically relevant animal models.