gebhart/patrepeval huggingface dataset:
Characterization of a first-pass gradient-echo spin-echo method to predict brain tumor grade and angiogenesis. (2004)

Combined GE and SE MR imaging provides information consistent with neoplastic angiogenesis, demonstrating its potential to aid in optimizing treatments, categorizing lesions, and influencing patient care.
Nonintrusive Measurements for Detecting Progressive Equipment Faults (2022)

The gradual environmental degradation of materials can lead to corrosion and mechanical failures of electrical loads. Vibration and corrosion both contribute to the failure of electrical connections and conductors, and electrical arcs destroy materials in ways that enhance the opportunities for further damage. These failures lead to loss of system capability and the possibility of electrical fires. The signatures of these impending electrical failures, which may occur over weeks or months, can be detected in many systems through nonintrusive electrical monitoring. This paper demonstrates techniques for decoding the type of electrical signatures that lead to progressive failure. Example applications of these techniques are illustrated with observations of the degradation and failure of copper-sheathed jacket water heaters aboard a United States Coast Guard vessel. Electrical, material, and vibration analysis are presented to demonstrate the basis for diagnostic electrical signatures.
Pepsin 5 (gastricsin): atypical pH profile of mucolytic activity (1990)

Conference Article| December 01 1990 Pepsin 5 (gastricsin): atypical pH profile of mucolytic activity J. P. PEARSON; J. P. PEARSON 1Department of Physiological Sciences, University of Newcastle upon Tyne NE2 4HH, U.K. Search for other works by this author on: This Site PubMed Google Scholar A. BLACKBURN; A. BLACKBURN 1Department of Physiological Sciences, University of Newcastle upon Tyne NE2 4HH, U.K. Search for other works by this author on: This Site PubMed Google Scholar A. ALLEN; A. ALLEN 1Department of Physiological Sciences, University of Newcastle upon Tyne NE2 4HH, U.K. Search for other works by this author on: This Site PubMed Google Scholar C. VENABLES C. VENABLES 1Department of Physiological Sciences, University of Newcastle upon Tyne NE2 4HH, U.K. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Received: June 19 1990 Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1990 Biochemical Society1990 Biochem Soc Trans (1990) 18 (6): 1255. https://doi.org/10.1042/bst0181255 Article history Received: June 19 1990 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation J. P. PEARSON, A. BLACKBURN, A. ALLEN, C. VENABLES; Pepsin 5 (gastricsin): atypical pH profile of mucolytic activity. Biochem Soc Trans 1 December 1990; 18 (6): 1255. doi: https://doi.org/10.1042/bst0181255 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1990 Biochemical Society1990 Article PDF first page preview Close Modal You do not currently have access to this content.
Repeated Vaccination of Cows with HIV Env gp140 during Subsequent Pregnancies Elicits and Sustains an Enduring Strong Env-Binding and Neutralising Antibody Response (2016)

An important feature of a potential vaccine against HIV is the production of broadly neutralising antibodies (BrNAbs) capable of potentially blocking infectivity of a diverse array of HIV strains. BrNAbs naturally arise in some HIV infected individuals after several years of infection and their serum IgG can neutralise various HIV strains across different subtypes. We previously showed that vaccination of cows with HIV gp140 AD8 trimers resulted in a high titre of serum IgG against HIV envelope (Env) that had strong BrNAb activity. These polyclonal BrNAbs concentrated into the colostrum during the late stage of pregnancy and can be harvested in vast quantities immediately after calving. In this study, we investigated the effect of prolonged HIV gp140 vaccination on bovine colostrum IgG HIV Env-binding and BrNAb activity over subsequent pregnancies. Repeated immunisation led to a maintained high titre of HIV Env specific IgG in the colostrum batches, but this did not increase through repeated cycles. Colostrum IgG from all batches also strongly competed with sCD4 binding to gp140 Env trimer and with human-derived monoclonal VRC01 and b12 BrNAbs that bind the CD4 binding site (CD4bs). Furthermore, competition neutralisation assays using RSC3 Env gp120 protein core and a derivative CD4bs mutant, RSC3 Δ371I/P363N, showed that CD4bs neutralising antibodies contribute to the neutralising activity of all batches of purified bovine colostrum IgG. This result indicates that the high IgG titre/avidity of anti-CD4bs antibodies with BrNAb activity was achieved during the first year of vaccination and was sustained throughout the years of repeated vaccinations in the cow tested. Although IgG of subsequent colostrum batches may have a higher avidity towards the CD4bs, the overall breadth in neutralisation was not enhanced. This implies that the boosting vaccinations over 4 years elicited a polyclonal antibody response that maintained the proportion of both neutralising and non-neutralising CD4bs antibodies.
Quantum Effect Modeling in Thin Film Independent Double Gate Capacitorless eDRAM (2009)

International audience
Ethernet passive optical network (EPON) system with storage function (2006)

Ethernet Passive Optical Network (EPON) is an emerging access network technology that provides high bandwidth and cost-effective access lines between a carrier's central office (CO) and a customer site. But limited bandwidth is still a problem in EPON system. In this paper, we propose a new architecture for EPON system with storage function. Storage is embedded in optical network unit (ONU) to store data especially video data by checking the Logical Link Identifier (LLID). Subscribers can retrieve the data directly from the storage by sending requests to ONUs.
Prothrombin Time and Activated Partial Thromboplastin Time Testing: A Comparative Effectiveness Study in a Million-Patient Sample (2015)

This study sought to bring the availability of big data together with applied comparative effectiveness research. Among preoperative patients, 26.2% received PT tests, and 94.3% of tests were unnecessary, given the absence of findings on H&P. Similarly, 23.3% of preoperative patients received aPTT tests, of which 99.9% were unnecessary. Among patients with no H&P findings suggestive of bleeding risk, 6.6% of PT tests and 7.1% of aPTT tests were either a false positive or a true positive (i.e. indicative of a previously-undiagnosed potential bleeding risk). Both PT and aPTT, designed as diagnostic tests, are apparently used as screening tests. Use of unnecessary screening tests raises concerns for the costs of such testing and the consequences of false positive results.
Supplementary Figure S3 from EGFR and RB1 as Dual Biomarkers in HPV-Negative Head and Neck Cancer (2023)

&lt;p&gt;Kaplan-Meier survival curves for T1/2 and T3/4 tumors stratified by the expression of (A) EGFR and (B) HER2. Based on AQUA-expression scores.&lt;/p&gt;
Temperature-responsive biometamaterials for gastrointestinal applications (2019)

We hypothesized that ingested warm fluids could act as triggers for biomedical devices. We investigated heat dissipation throughout the upper gastrointestinal (GI) tract by administering warm (55°C) water to pigs and identified two zones in which thermal actuation could be applied: esophageal (actuation through warm water ingestion) and extra-esophageal (protected from ingestion of warm liquids and actuatable by endoscopically administered warm fluids). Inspired by a blooming flower, we developed a capsule-sized esophageal system that deploys using elastomeric elements and then recovers its original shape in response to thermal triggering of shape-memory nitinol springs by ingestion of warm water. Degradable millineedles incorporated into the system could deliver model molecules to the esophagus. For the extra-esophageal compartment, we developed a highly flexible macrostructure (mechanical metamaterial) that deforms into a cylindrical shape to safely pass through the esophagus and deploys into a fenestrated spherical shape in the stomach, capable of residing safely in the gastric cavity for weeks. The macrostructure uses thermoresponsive elements that dissociate when triggered with the endoscopic application of warm (55°C) water, allowing safe passage of the components through the GI tract. Our gastric-resident platform acts as a gram-level long-lasting drug delivery dosage form, releasing small-molecule drugs for 2 weeks. We anticipate that temperature-triggered systems could usher the development of the next generation of stents, drug delivery, and sensing systems housed in the GI tract.
Optimization of photocrosslinked gelatin/hyaluronic acid hybrid scaffold for the repair of cartilage defect (2019)

There is no therapy currently available for fully repairing articular cartilage lesions. Our laboratory has recently developed a visible light-activatable methacrylated gelatin (mGL) hydrogel, with the potential for cartilage regeneration. In this study, we further optimized mGL scaffolds by supplementing methacrylated hyaluronic acid (mHA), which has been shown to stimulate chondrogenesis via activation of critical cellular signalling pathways. We hypothesized that the introduction of an optimal ratio of mHA would enhance the biological properties of mGL scaffolds and augment chondrogenesis of human bone marrow-derived mesenchymal stem cells (hBMSCs). To test this hypothesis, hybrid scaffolds consisting of mGL and mHA at different weight ratios were fabricated with hBMSCs encapsulated at 20 × 10<sup>6</sup> cells/ml and maintained in a chondrogenesis-promoting medium. The chondrogenenic differentiation of hBMSCs, within different scaffolds, was estimated after 8 weeks of culture. Our results showed that mGL/mHA at a 9:1 (%, w/v) ratio resulted in the lowest hBMSC hypertrophy and highest glycosaminoglycan production, with a slightly increased volume of the entire construct. The applicability of this optimally designed mGL/mHA hybrid scaffold for cartilage repair was then examined in vivo. A full-thickness cylindrical osteochondral defect was surgically created in the rabbit femoral condyle, and a three-dimensional cell-biomaterial construct was fabricated by in situ photocrosslinking to fully fill the lesion site. The results showed that implantation of the mGL/mHA (9:1) construct resulted in both cartilage and subchondral bone regeneration after 12 weeks, supporting its use as a promising scaffold for repair and resurfacing of articular cartilage defects, in the clinical setting.
Synthesis and structural optimization of 2,7,9-trisubstituted purin-8-ones as FLT3-ITD inhibitors (2022)

Abstract Therapy of FLT3-positive acute myeloid leukemia still remains complicated, despite the availability of newly approved kinase inhibitors. Various strategies to avoid reduced efficacy of therapy are explored including the development of dual targeting compounds, which inhibit FLT3 and another kinase necessary for survival and proliferation of AML cells. We have designed new 2,7,9-trisubstituted 8-oxopurines as FLT3 inhibitors and report here structure-activity relationship studies. We demonstrated that substituents at positions 7 and 9 modulate activity between CDK4 and FLT3 kinase and the isopropyl group at position 7 increased substantially the selectivity toward FLT3 kinase, which led to the discovery of compound 15a (9-cyclopentyl-7-isopropyl-2-((4-(piper-azin-1-yl)phenyl)amino)-7,9-dihydro-8 H -purin-8-one). Cellular analyses in MV4-11 cells revealed inhibition of autophosphorylation of FLT3 kinase in nanomolar doses including suppression of downstream STAT5 and ERK1/2 phosphorylation. We also describe mechanistic studies in cell lines and activity in a mouse xenograft model in vivo.
Intrauterine transfusion for rhesus alloimmunization elevates fetal β2-microglobulin levels (2003)

We conclude that intrauterine transfusion for fetal anemia is associated with increased beta2-microglobulin levels, suggesting immunomodulatory effects of intrauterine transfusion on host immune responses to donor leukocyte antigens.
Isochronous Resource Reservation for the Deterministic Delay Guaranteed Collaboration (2007)

With increasing processor speeds and convergence on wired-wireless networks, the potential for computing complex behavior in real-time collaboration has greatly improved. In recent years, distributed virtual environments have become a major trend and application fields of collaboration have been diffused into machine-to-machine services. Collaboration requires communication channels among resources and coordination functions for the integration and harmonious adjustment of the individual work effort towards the accomplishment of a goal. For realizing the advanced collaborative environments, highly interactive communication will be indispensable. New features from Ethernet technology to meet delay and jitter requirements for time-constrained collaboration will be required. In this paper, to obtain the deterministic latency transport for supporting the time- constrained collaboration, Ethernet frame forwarding with the isochronous resource reservation is proposed. We define the isochronous forwarding window which is the time duration and virtually identified on point-to-point links, and propose the resource reservation in terms of isochronous forwarding window with the admission algorithm based on probabilistic admitted level of quality for the collaboration communication channel.
Room-temperature synthesis of crystalline molybdenum and tungsten carbides, Mo sub 2 C and W sub 2 C, via chemical-reduction methods. Technical report (1992)

The species MOC13(TBF)3, MOC14(THF)2 and WC14 have been reduced in THF solution with LiBEt3H to give black, homogeneous solutions. The black product could be separated from the other reaction by-products to give either a colloidal black solution or an agglomerated black precipitate. TEM of the dried colloidal solutions showed the presence of monodispersed 1-2nm sized particles which gave a broad electron diffraction rings corresponding to a d-spacing of -2.4 Anstrom Energy dispersive spectroscopy showed only the presence of Mo or W depending on which starting material was used. The black precipitates were shown to be agglomerates of the 1-2nm crystallites. X-ray powder diffraction data also showed a broad peak centered at 2.4 Anstrom for Mo2C and 2.3 Anstrom for W2C. On heating the peaks sharpened and a number of other lower intensity peaks emerged that were consistent with the presence of crystalline M2C (M = Mo, 500 deg C or W, 450 deg C) rather than the expected metal products. The identity Of M2C was confirmed by elemental analysis and by TGA oxidation experiments.
Software debugging, testing, and verification (2002)

In commercial software development organizations, increased complexity of products, shortened development cycles, and higher customer expectations of quality have placed a major responsibility on the areas of software debugging, testing, and verification. As this issue of the IBM Systems Journal illustrates, there are exciting improvements in the underlying technology on all three fronts. However, we observe that due to the informal nature of software development as a whole, the prevalent practices in the industry are still immature, even in areas where improved technology exists. In addition, tools that incorporate the more advanced aspects of this technology are not ready for large-scale commercial use. Hence there is reason to hope for significant improvements in this area over the next several years.
Reconstruction of Viscosity Maps in Elastography using Ultrasound Shear Wave Attenuation (2019)

Changes in viscoelastic properties of biological tissues may be symptomatic of a dysfunction that can be correlated to tissue pathology. Past magnetic resonance imaging studies suggest that tumors have higher viscosity than normal tissues, and fatty organs might also correlate with higher viscosity. In this study, a frequency-shift method to compute attenuation was utilized to reconstruct viscosity maps by analyzing spectral properties of induced shear waves. The feasibility of viscosity reconstructions in animal tissue samples is investigated. Experiments were performed in an in vitro phantom, as well as in ex vivo and in vivo animal tissue samples of healthy and fatty livers. Quantitative values of viscosity obtained for two porcine liver tissues, two fatty duck liver samples, and one goose fatty liver imaged in vivo are 0.61 ± 0.21, 0.52 ± 0.35; 1.28 ± 0.54, 1.36 ± 0.73, and 1.67 ± 0.70 Pa.s, respectively.
Immature truncated O-glycophenotype of cancer directly induces oncogenic features (2014)

Aberrant expression of immature truncated O-glycans is a characteristic feature observed on virtually all epithelial cancer cells, and a very high frequency is observed in early epithelial premalignant lesions that precede the development of adenocarcinomas. Expression of the truncated O-glycan structures Tn and sialyl-Tn is strongly associated with poor prognosis and overall low survival. The genetic and biosynthetic mechanisms leading to accumulation of truncated O-glycans are not fully understood and include mutation or dysregulation of glycosyltransferases involved in elongation of O-glycans, as well as relocation of glycosyltransferases controlling initiation of O-glycosylation from Golgi to endoplasmic reticulum. Truncated O-glycans have been proposed to play functional roles for cancer-cell invasiveness, but our understanding of the biological functions of aberrant glycosylation in cancer is still highly limited. Here, we used exome sequencing of most glycosyltransferases in a large series of primary and metastatic pancreatic cancers to rule out somatic mutations as a cause of expression of truncated O-glycans. Instead, we found hypermethylation of core 1 β3-Gal-T-specific molecular chaperone, a key chaperone for O-glycan elongation, as the most prevalent cause. We next used gene editing to produce isogenic cell systems with and without homogenous truncated O-glycans that enabled, to our knowledge, the first polyomic and side-by-side evaluation of the cancer O-glycophenotype in an organotypic tissue model and in xenografts. The results strongly suggest that truncation of O-glycans directly induces oncogenic features of cell growth and invasion. The study provides support for targeting cancer-specific truncated O-glycans with immunotherapeutic measures.
Second harmonic generation from beta barium borate (β-BaB2O4) thin films grown by metalorganic chemical vapor deposition (1997)

Thin films of beta barium borate (β-BaB2O4) have been deposited by metalorganic chemical vapor deposition on fused silica, sapphire, platinum, and silicon substrates. Deposition conditions were optimized to reproducibly grow films with the c axis normal to the substrate. Second harmonic generation measurements have been made on selected films. The films grown on fused silica exhibit a maximum χeff(2) of 0.78 pm/V, and on single-crystal sapphire, 1.6 pm/V.
Prosthetic complications with dental implants: a bibliometric analysis of 20 top-cited articles (2023)

The purpose of this review was to explore the 20 most cited articles on prosthetic complications with dental implants. Identification of such articles could be helpful in prosthodontics residency programmes in devising the curriculum of essential reading material in implantology. The Institute for Scientific Information, Web of Science Database, and Google Scholar were used to identify the 20 top-cited articles published in journals from 1980 till June 2021. These articles were then evaluated according to the number of citations, authors, study design, publication year, and publishing journal. Descriptive statistics were computed for bibliometrics. It was observed that the citation count ranged from 6,391 to 315 (in descending order). The Toronto study is the most cited study on dental implant prosthetic complications. Prospective studies and systematic and narrative reviews were the predominant study designs used in the articles; however, alarmingly no randomised controlled trials were included in the list.
1CPN: A coarse-grained multi-scale model of chromatin (2019)

A central question in epigenetics is how histone modifications influence the 3D structure of eukaryotic genomes and, ultimately, how this 3D structure is manifested in gene expression. The wide range of length scales that influence the 3D genome structure presents important challenges; epigenetic modifications to histones occur on scales of angstroms, yet the resulting effects of these modifications on genome structure can span micrometers. There is a scarcity of computational tools capable of providing a mechanistic picture of how molecular information from individual histones is propagated up to large regions of the genome. In this work, a new molecular model of chromatin is presented that provides such a picture. This new model, referred to as 1CPN, is structured around a rigorous multiscale approach, whereby free energies from an established and extensively validated model of the nucleosome are mapped onto a reduced coarse-grained topology. As such, 1CPN incorporates detailed physics from the nucleosome, such as histone modifications and DNA sequence, while maintaining the computational efficiency that is required to permit kilobase-scale simulations of genomic DNA. The 1CPN model reproduces the free energies and dynamics of both single nucleosomes and short chromatin fibers, and it is shown to be compatible with recently developed models of the linker histone. It is applied here to examine the effects of the linker DNA on the free energies of chromatin assembly and to demonstrate that these free energies are strongly dependent on the linker DNA length, pitch, and even DNA sequence. The 1CPN model is implemented in the LAMMPS simulation package and is distributed freely for public use.
A multichannel time-of-flight system for observation of energetic ions of multispecies generated from relativistic laser plasma (2010)

A multichannel time-of-flight (TOF) system was constructed to observe the ions generated from relativistic laser plasma, where the ions have polychromatic energies and multiple species. The TOF system is composed of a ten-channel scintillation detector array and an electromagnet that generates a magnetic field of 0-1.24 T. The magnet field enables us to analyze protons, deuterons, and full-stripped carbon ions to 50, 25, and 150 MeV, respectively. The system experimentally identified protons of 0.27-1.6 MeV energy and ions of a half specific charge (deuterons of 0.3-0.8 MeV and full-stripped carbons of 1.8-4.8 MeV). The measured TOF values agree well with the calculated values within the designed accuracy; +/-2.5 ns for protons and +/-5 ns for the others (d or C(6+)) on each detector channel. Comparison of ion numbers detected by a track detector (CR-39) and the TOF system enabled us to obtain the number of ions detected on each scintillation counter with less than 16% error.