gebhart/patrepeval huggingface dataset:
Supplementary Figures 1 - 7 from Mechanism, Consequences, and Therapeutic Targeting of Abnormal IL15 Signaling in Cutaneous T-cell Lymphoma (2023)

&lt;p&gt;Supplementary Figures 1 - 7. Supplementary Figure 1. Immunoblot analysis of IL-15 in normal donor CD4+ T-cells, SS patient CD4+ T-cells and patient derived cell lines. Supplementary Figure 2. Representative flow cytometric histogram is shown for CD3 expression in mononuclear cells from skin of WT and IL-15 tg mice. Supplementary Figure 3. Immunoblot analysis of HDAC1 in normal donor CD4+ T-cells, SS patient CD4+ T-cells and patient derived cell line, Hut78. Protein lysates were probed for expression of HDAC1; β-Actin was used as housekeeping control. Supplementary Figure 4. Immunoblot analysis for expression of p21 protein in normal donor CD4+ cells following ten days of incubation in IL-15 compared to unstimulated normal donor CD4+ T-cells. Supplementary Figure 5. Pie chart showing the distribution of HDAC1 occupancy in normal donor CD4+ T-cells (upper left) compared to patient CD4+ T-cells (upper right) and normal donor CD4+ T-cells stimulated with 100ng/ml IL-15 for 24 hours (lower left). Supplementary Figure 6. High magnification and (B) low magnification histological analysis of IL-15 Tg skin. Supplementary Figure 7. The CTCL mouse disease severity scoring system is on a 0 to 100 scale, with 100 being the highest (most severe) score.&lt;/p&gt;
Editorial: Advanced Immunization Technologies for Next Generation Vaccines (2020)

EDITORIAL article Front. Immunol., 06 May 2020Sec. Vaccines and Molecular Therapeutics Volume 11 - 2020 | https://doi.org/10.3389/fimmu.2020.00878
Characterization and parameterized random generation of digital circuits (1996)

The development of new Field-Programmed, Mask-Programmed and Laser-Programmed Gate Array architectures is hampered by the lack of realistic test circuits that exercise both the architectures and their automatic placement and routing algorithms. In this paper, we present a method and a tool for generating parameterized and realistic random circuits. To obtain the realism, we propose a set of graph-theoretic characteristics that describe a physical netlist, and have built a tool that can measure these characteristics on existing circuits. The generation tool uses the characteristics as constraints in the random circuit generation. To validate the quality of the generated netlists, parameters that are not specied in the generation are c ompared with those of real circuits, and with those of \random" graphs. rameter which i s a c haracteristic of the circuit in question.
Using the 3D-SMS for finding starting configurations in imaging systems with freeform surfaces (2015)

As the scientific field of the freeform optics is newly developing, there is only a small number of approved starting systems for the imaging lens design. We investigate the possibility to generate starting configurations of freeform lenses with the Simultaneous Multiple Surface (SMS) method. Surface fit and transfer to the ray tracing program are discussed in detail. Based on specific examples without rotational symmetry, we analyze the potential of such starting systems. The tested systems evolve from Scheimpflug configurations or have arbitrarily tilted image planes. The optimization behavior of the starting systems retrieved from the 3D-SMS is compared to classical starting configurations, like an aspheric lens. Therefore we evaluate the root mean square (RMS) spot radius before and after the optimization as well as the speed of convergence. In result the performance of the starting configurations is superior. The mean RMS spot diameter is reduced about up to 17.6 % in comparison to an aspheric starting configuration and about up to 28 % for a simple plane plate.
Design, Synthesis, and in Vitro and in Vivo Evaluation of High Affinity and Specificity Near-Infrared Fluorescent Bombesin Antagonists for Tumor Imaging (2018)

The bombesin (BBN) antagonist binds with high affinity to the gastrin releasing peptide receptor (GRPr), a receptor overexpressed on many human cancers. We present an investigation employing BBN antagonist for highly specific near-infrared fluorescence (NIRF) imaging of GRPr-positive tumors. Nine NIRF-dye labeled BBN antagonists with differing linkers and dyes were synthesized and characterized to screen for the optimal agent. Three novel agents, AF750-G-pip-Sta-BBN (1), AF750-GSG-Sta-BBN (2), and AF750-6Ahx-Sta-BBN (3), exhibited an excellent binding-specificity and affinity to human PC-3 prostate cancer cells in vitro, and a remarkable in vivo tumor-selectivity and NIRF imaging sensitivity in PC-3 tumor-bearing mice. Compound 1 showed the fastest, and 3, the slowest, pharmacokinetics on the tumor sites. Despite of high tumor uptake, 2 had a low pancreas uptake distinct from 1 and 3 at 0.44 nmol dose. This difference was attributed to the inherent linker properties such as the hydrophilicity, polarity, and charge.
Cancellation of power amplifier induced nonlinear self-interference in full-duplex transceivers (2013)

Recently, full-duplex (FD) communications with simultaneous transmission and reception on the same channel has been proposed. The FD receiver, however, suffers from inevitable self-interference (SI) from the much more powerful transmit signal. Analogue radio-frequency (RF) and baseband, as well as digital baseband, cancellation techniques have been proposed for suppressing the SI, but so far most of the studies have failed to take into account the inherent nonlinearities of the transmitter and receiver front-ends. To fill this gap, this article proposes a novel digital nonlinear interference cancellation technique to mitigate the power amplifier (PA) induced nonlinear SI in a FD transceiver. The technique is based on modeling the nonlinear SI channel, which is comprised of the nonlinear PA, the linear multipath SI channel, and the RF SI canceller, with a parallel Hammerstein nonlinearity. Stemming from the modeling, and appropriate parameter estimation, the known transmit data is then processed with the developed nonlinear parallel Hammerstein structure and suppressed from the receiver path at digital baseband. The results illustrate that with a given IIP3 figure for the PA, the proposed technique enables higher transmit power to be used compared to existing linear SI cancellation methods. Alternatively, for a given maximum transmit power level, a lower-quality PA (i.e., lower IIP3) can be used.
Community Driven Digital Signal Processing Laboratories In Connexions (2020)

The conventional textbook is largely inadequate for digital signal processing (DSP) laboratory education due to inherent factors such as a small and fragmented market and rapid hardware obsolescence. Freely available open-content materials that enable and promote both local customization and further development by a community of educators offers a fresh approach to lab text development that can surmount these barriers. In this paper, we overview a joint effort organized by the Connexions Project to develop a large pool of DSP lab modules sufficient to serve as the complete, stand-alone text for several types of DSP lab courses.
Reducing Amyloid Plaque Burden via Ex Vivo Gene Delivery of an Aβ-Degrading Protease: A Novel Therapeutic Approach to Alzheimer Disease (2007)

Ex vivo gene delivery of an Abeta-degrading protease reduces amyloid plaque burden in transgenic mice expressing human APP. These results support the use of Abeta-degrading proteases as a means to therapeutically lower Abeta levels and encourage further exploration of ex vivo gene delivery for the treatment of Alzheimer disease.
Compact Reduced Order Modeling for Multiple-Port Interconnects (2006)

In this paper, we propose an efficient model order reduction (MOR) algorithm, called MTermMOR, for modeling interconnect circuits with large number of external ports. The proposed method overcomes the difficulty associated with Krylov subspace based projection MOR methods for reducing circuits with many ports. The novelty of the proposed method lies on the fact that we separately compute the poles and residues of each transfer function in the reduced admittance matrices. Specifically we apply traditional subspace projection method for computing poles and use hierarchical symbolic analysis for computing frequency responses of admittances to determine the residues of transfer functions. In this way, we only use necessary poles (smaller number of poles) to archive the same accuracy than subspace projection based methods. Finally convex programming based optimization is used to enforce the passivity of the reduced models. The new method can lead to much smaller reduced models for a given frequency range or much higher accuracy given the same model sizes than subspace projection based methods for multi-port interconnect circuits. Experimental results on several industry interconnect circuits demonstrate the advantage of the proposed method over the subspace projection based methods.
A review of semi-synthetic biopolymer complexes: modified polysaccharide nano-carriers for enhancement of oral drug bioavailability (2016)

Semi-synthetic biopolymer complexes (SSBCs) have potential as nano-carriers for oral drug delivery due to their exceptional properties obtained by merging the properties of synthetic (e.g. good thermal and mechanical properties) with natural polymers (e.g. biocompatibility); thus, forming a new class of biopolymer materials incorporating the best of both worlds. Despite development in drug delivery systems, oral administration of therapeutic agent is still preferred. Several nano-polymeric systems has been prepared and characterized based on both synthetic polymers and natural polymers, each with its limitations and advantages. Among natural polymers, alginate, chitosan, and hyaluronic acid (HA) have been studied broadly for the fabrication of nanoparticles systems. This review discusses a newly investigated class of polymer called SSBCs as oral drug nano-carriers. It also discusses certain significant structural and functional attributes or effects which are essential to be taken into consideration when an oral drug delivery system is developed. The review is aimed at describing complexation of few natural polymers (e.g. polysaccharides) with selected synthetic polymers or synthetic chemicals to indicate some of the factors that influence preparation, solubility, formation, and stability of these SSBCs.
ChemInform Abstract: NUCLEOPHILER CHARAKTER VON IN REDOXPROZESSEN GEBILDETEN ALKYLRADIKALEN 3. MITT. REAKTIVITAET VON ALKYLRADIKALEN GEGENUEBER KONJUGIERTEN OLEFINEN (1970)

Abstract Das aus dem Redoxsystem 1‐Methoxy‐cyclohexylhydroperoxid/Fe2 erhaltene Radikal (IIIa) reagiert mit einem Gemisch der konjugierten Olefine (I) und (II) in Methanol zu den entsprechenden Methoxyderivaten (IVa) und (Va), sowie im Falle von (IIa) bzw. (IIc) zusätzlich zu den entsprechenden Methoxyderivaten (VIa) und (VIIa) und im Falle der Carboxylverbindungen (IIb) bzw. (IIc) noch zusätzlich zum entsprechenden Lacton (VIII).
Metal germanides for practical on-chip plasmonics in the mid infrared (2018)

Metal germanide thin films were investigated for infrared plasmonic applications. Thin films of copper and nickel were deposited onto amorphous germanium thin films and subsequently annealed at a range of temperatures. X-ray diffraction was used to identify stoichiometry, and SEM micrographs, energy dispersive spectroscopy, and atomic force microscopy were used to characterize composition and film quality. Electrical properties were analyzed via Hall measurements. Complex permittivity spectra were measured from 2 to 15 µm using IR ellipsometry. From this, surface plasmon polariton (SPP) characteristics such as propagation length and mode confinement were calculated and used to determine appropriate spectral windows for plasmonic applications with respect to film characteristics. Films were compared to similar palladium germanide and platinum germanide thin films and were evaluated for use with on-chip plasmonic components.
Double-layer silicon photonic crystal fiber tip temperature sensor (2012)

We describe the fabrication of a double-layer silicon photonic crystal using self-aligned CMOS-compatible processes and its assembly on a single mode fiber using a wafer template and epoxy bonding. The fiber sensor has sharper resonances and higher temperature sensitivity than the previously-reported single-layer sensor. The new assembly method facilitates batch-production of the sensor and allows for extension to high temperature measurement.
Methylene Green Electrodeposited on SWNTs-Based “Bucky” Papers for NADH and l-Malate Oxidation (2011)

This research introduces a cavity anode design based on new single-walled nanotube (SWNTs) papers, "bucky" papers, used for the oxidation (and regeneration) of nicotinamide adenine dinucleotide (NADH) and the oxidation of l-malate. The materials designed are paper-like processed composites containing also additives: BP11 sample contains SWNTs and isopropanol (IPA); the BPMG sample contains SWNTs, IPA, and methylene green (MG). NADH/NAD(+) is the cofactor responsible for the oxidation of l-malate by malate dehydrogenase (MDH), in the Krebs' cycle. Because of the high overpotential of NADH oxidation, poly methylene green (PMG) was utilized as the electrocatalyst to produce NAD(+). The electrocatalyst was deposited on the surface of the "bucky" papers by electropolymerization by means of 10 voltammetric cycles in a range of -0.5 V and +1.3 V (vs Ag/AgCl reference electrode) at a scan rate of 5 mV/s. The catalytic performance of PMG was evaluated by chronoamperometric measurements of NADH oxidation at 0.3 V in phosphate buffer and l-malate oxidation at 0.1 V in the presence of MDH. For both "bucky" papers, the chronoamperometric curves of PMG, current vs NADH concentration, show a linear relationship demonstrating to have a first order Fick's law behavior for concentrations of NADH lower than 6 mM. The chronoamperometric curves in the presence of MDH, current against l-malate concentration, show a Michaelis-Menten behavior where no inhibition or competitive reaction are detected. Additionally, the anodic materials were characterized by scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS), the polymerization of MG is effectively observed in the form of particles nucleation. The anodes show an excellent electrocatalytic activity toward NADH oxidation. The electrode design is feasible, reproducible, and overall stable.
Posterior Lumbar Interbody Fusion Using a Porous PEEK Implant and Bone Marrow Concentrate (2020)

Objective: We report the 1-year results of a prospective, singlecenter clinical study in which a posterior lumbar interbody fusion (PLIF) was performed using a novel porous polyether ether ketone (PEEK) implant and pedicle screw fixation in patients with symptomatic single-level degenerative lumbar disc disease.

Methods: Thirty consecutive patients with single-level symptomatic degenerative lumbar disc disease were enrolled in the study. All patients underwent a single level PLIF procedure using a porous PEEK implant with pedicle screw fixation and bone marrow concentrate applied to a ceramic carrier. Patients were assessed preoperatively and at 1.5, 3, 6, and 12 months after surgery. Standardized outcome measures were used to evaluate the patient’s condition before and after surgery. Plain radiographs were used to assess fusion, sagittal plane angulation, bony ingrowth, subsidence, and migration of the implant.

Results: Three patients were lost to follow up after their 3-month follow-up visits and were removed from the study; 27 patients were followed for a minimum of 12 months. At their last follow up, Oswestry disability index (ODI) scores and back and leg pain scores showed improvement in all patients. All patients showed radiographic fusion with no motion across the instrumented interspaces on dynamic flexion-extension lateral radiographs. Segmental lordosis at the surgical site improved from -1° to an average of -7° (0° to -9°) with no evidence of implant migration or subsidence. Average disc space height increased 6 mm. No patient showed radiographic evidence of a pseudarthrosis. No patient developed radiolucency at the implant interface with the host bone.

Conclusion: We found that used of a porous-surface PEEK implant with bone marrow concentrate on a ceramic carrier is a clinically viable alternative for improving the osseointegration and fusion rates in patients undergoing single-level PLIF surgery for degenerative disc disease in the lumbar spine.
Cardiac echo-planar MR imaging: comparison of single- and multiple-shot techniques. (1995)

Multiple-shot EPI rendered higher quality images than did single-shot EPI.
Gas-liquid flow generated by a pitched blade turbine: pitched-blade turbine measurements and computational fluid dynamics simulations (2003)

Axial-flow impellers, like pitched-blade impellers, are being increasingly used for gas-liquid systems in stirred vessels. In this work we have used particle image velocimetry (PIV) and computational fluid dynamics (CFD) models to investigate gas-liquid flow generated by a downflow pitched-blade turbine. PIV measurements were carried out in a fully baffled stirred vessel (of 0.19 m diameter) with a dished bottom. Angle-resolved measurements of the flow field with and without gas dispersion were carried out. An attempt was made to capture key details of the trailing vortex, the accumulation of gas, and the flow around the impeller blades. A two-fluid model along with the standard k-e turbulence model was used to simulate dispersed gas-liquid flow in a stirred vessel. The computational snapshot approach was used to simulate impeller rotation and was implemented in the commercial CFD code, FLUENT 4.5 (of Fluent Inc., USA). The model predictions were verified by comparison with the PIV measurements and other available experimental data. The computational model and results discussed in this work are useful for better understanding and simulation of gas-liquid flow generated by axial impellers in stirred vessels.
Single Dielectric Barrier Discharge Plasma Actuators for Improved Airfoil Performance (2009)

The applicability of single dialectic barrier discharge plasma actuators for use as active flow control devices, capable of enhancing the performance of airfoils, was assessed in this investigation. Measurements were carried out on two thick airfoils with simple flaps: a NACA0021 and an airfoil that is similar to those commonly used on tiltrotor aircraft. The chord length of the airfoils was approximately 0.3 and 0.25 m, respectively, and the span was approximately 0.6 m. They were both tested in the same wind tunnel with a test section of 0.6 x 1.1 m. Freestream velocities varying from 5 to 15 m/s were tested, corresponding to chord Reynolds numbers ranging between 0.8 × 10 5 and 3 × 10 5 . The lift, moment, and form drag were obtained from the pressure distributions over the airfoil's surface, and the total drag was calculated from a wake survey. The range of incidence angles α varied from ―4deg <α < +20 deg and flap deflections δ f of 0 and 15 deg were tested. The location of the actuation was also altered. Two data sets are presented: one in which the actuator was placed at approximately 5 % of the chord and the other in which it was located just upstream of the flap shoulder at a chord location corresponding to about 75 %. The momentum input of the single dialectic barrier discharge plasma actuators was measured with a hot wire and was in good agreement with previously published results. The input momentum is very weak and is not sufficient to prevent separation at Reynolds numbers greater than 100,000. The single dialectic barrier discharge plasma actuators used in this study may only provide sufficient momentum to be effective at very low Reynolds numbers, such as those appropriate to micro air vehicles. Under special circumstances, their passive presence on the surface may trip the boundary layer, making it more resistant to separation, but in those cases, a proper roughness strip or vortex generators may delay separation more effectively.
Control of a class of multivariable nonlinear systems without vector relative degrees: a backstepping approach (2002)

A new control approach for a class of multivariable nonlinear systems whose decoupling matrix is singular is presented. For this class of systems, local decoupling may be achieved by dynamic compensation. Instead of decoupling the nonlinear system by adding chains of integrators in the input channels, we modify the dynamic extension algorithm by incorporating backstepping design methods to partially close the loop in each design step. The resulting control law by this new approach is a static state feedback law. Although the final closed loop form of the nonlinear system is not decoupled, each output is controlled to the desired value asymptotically. A design example is given to illustrate this approach.
Integration of Functional Optical Devices Using Photonic Crystals (2005)

Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text A. Scherer, "Integration of Functional Optical Devices Using Photonic Crystals," in Integrated Photonics Research and Applications/Nanophotonics for Information Systems, Technical Digest (Optica Publishing Group, 2005), paper NThC1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Identification of a Novel Homozygous Deletion Region at 6q23.1 in Medulloblastomas Using High-Resolution Array Comparative Genomic Hybridization Analysis (2005)

Current array comparative genomic hybridization analysis generates a comprehensive pattern of chromosomal aberrations in medulloblastomas. This information will lead to a better understanding of medulloblastoma tumorigenesis. The delineated regions of gains or losses will indicate locations of medulloblastoma-associated genes. A 0.887 Mbp homozygous deletion region was newly identified at 6q23.1. Frequent detection of reduced expression of AK091351 and KIAA1913 genes implicates them as suppressors of medulloblastoma tumorigenesis.
ChemInform Abstract: Stereoselective One‐Pot Synthesis of β‐Lactams by Reaction of 2‐ Pyridylthioesters with Imines in the Presence of AlBr3 or EtAlCl2. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Momilactone B, an Allelochemical of Rice Hulls, Induces Apoptosis on Human Lymphoma Cells (Jurkat) in a Micromolar Concentration (2008)

Although momilactone B has been studied as an allelochemical of rice (Oryza sativa L.), to date we have no report showing the effect of momilactone B on mammalian cells. This study was undertaken to examine whether this allelochemical has anticancer activity on cancer cells. We show here that momilactone B at micromolar doses has antitumor efficacy by inducing apoptosis in several blood cancer cells including human leukemic T cells. In addition, our study elucidated that anticancer activity of momilactone B on human leukemic T cells resulted from the induction of apoptosis via caspase and mitochondria. From these results, momilactone B can be considered as a novel therapeutic strategy for human leukemic T cells from its direct apoptosis-inducing activity.