gebhart/patrepeval huggingface dataset:
Dual-phase argon ionization detector for measurement of coherent elastic neutrino scattering and medium-energy nuclear recoils (2006)

We propose to build and deploy a 10-kg dual-phase argon ionization detector for the detection of coherent neutrino-nucleus scattering, which is described by the reaction; (V) + (Z,N) {yields} (v) + (Z,N). Our group would be the first to make this measurement. Its detection would validate (or refute) central tenets of the Standard Model. The existence of this process is also relevant to astrophysics, where coherent neutrino scattering is assumed to impede energy transport within neutron stars. We have built a gas-phase argon ionization detector to determine the feasibility of measuring small recoil energies ({approx}1keV) predicted from coherent neutrino scattering, and to characterize the recoil spectrum of the argon nuclei induced by scattering from medium-energy neutrons. We present calibrations made with 55-Fe, a low energy x-ray source, and describe a planned measurement of the recoil spectra from the 60keV Lithium-target neutron generator at LLNL. A high signal-to-noise measurement of the recoil spectrum will not only serve an important milestone in achieving the sensitivity necessary for measuring coherent neutrino-nucleus scattering, but will break new scientific ground by providing a first ever measurement of low-energy quenching factors in argon. Coherent scattering occurs when the momentum transfer from a neutrino to the nucleus is much smaller than the inverse size of the recoil nucleus. A detection of coherent neutrino-nucleus scattering would verify an unconfirmed Standard Model prediction [1], explore non-standard neutrino-quark interactions, confirm stellar collapse and supernova energy transport and neutrino opacity models, and could be applied to the measurement of the flavor-blind neutrino spectrum from next nearby supernova, or could be used to promote non-intrusive reactor power monitoring [2]. We propose detecting the ionization induced by recoiling argon nuclei using a 10 kg dual-phase argon detector. The principle of dual-phase detection has been described elsewhere [3]. We propose using a 3 GW commercial nuclear reactor as a source of antineutrinos. We have designed and built a gas-phase prototype of the detector with which we have measured the 200-electron equivalent ionization signals from a 6keV Fe-55 source with a signal-to-noise threshold of 50 electrons. This prototype also enables study of scintillation properties of Argon and investigation of electron and nuclear recoils in Argon. We will measure medium energy neutron-nuclear recoils in our prototype detector using the recently-commissioned LLNL compact pulsed neutron source.
A subspace matching color filter design methodology for a multispectral imaging system (2006)

In this paper, we present a methodology to design filters for an imaging system to improve the accuracy of the spectral measurements for families of reflective surfaces. We derive the necessary and sufficient conditions that the sensor space of the system must obey in order to measure the spectral reflectance of the surfaces accurately. Through simulations, we show how these conditions can be applied to design filters using a set of sample spectral data acquired from extracted teeth. For this set of data, we also compare our results to those of Wolski's method, a conventional filter design method which produces filters that recover tristimulus values of surfaces accurately under several illuminants. We show that our method produces filters that capture the spectral reflectance better given the same number of measurements. The errors in predicting the color of the sample data are much lower under every test illuminant when the filters designed with our method are used.
Abstract A14: Overcoming therapeutic MAb resistance in agressive HER2 positive breast carcinomas by adoptive immunotherapy using optizimed effectors cells (2015)

Abstract Trastuzumab, a monoclonal antibody targeting HER2 has been demonstrated to improve survival of HER2 overexpressing metastatic breast cancer. However, half of patients who initially respond to Trastuzumab develop resistance within one year of treatment initiation. Alteration of Antibodies Dependant Cellular Cytotoxicity (ADCC) mechanisms is one of the rational mechanisms for resistance to therapeutic Mab. The goal of this project is to overcome this resistance by adoptive transfer using genetically engineered optimized NK cells. We thus compare efficacy of two different approaches: (i) NK cells armed with a high affinity Fc domain (FcγRIIIα/CD16) linked to its transduction chain FCεRIγ to generate NK-CD16/γ cells that allow recognition and interaction with Mab, inducing ADCC and (ii) NK cells expressing Trastuzumab sequence fused to the transduction chain FCεRIγ to generate NK-Her/γ that directly kill the HER2 positively cells. In vitro, both strategies demonstrated high cytotoxic efficacy against HER2 positive cells, with direct killing systematically more efficient (reaching up to 95% with ratio E:T 5:1). Interestingly, two steps killing with NK-CD16/γ enabled a very specific cytotoxicity only in the presence of specific antibody. We demonstrated that efficacy of lysis is linked (i) to effector dose, (ii) levels of CD16/γ expression on effectors cells, (iii) HER2 expression but not level on target cells In vivo, in Trastuzumab resistant HER2+ xenograft immunodeficient NSG mice model, complete regression was obtained only when using NK-CD16/γ in the presence of Trastuzumab. Even if the NK-Her/γ was found by IF or FACS in the tumor after IV or IP injection, they could not induce tumor regression. Analyses of NK dysfunction will be presented. Restoration or improvement of effectors cells might be considerate as an issue in therapeutic Mab resistance treatment. Successful immune-based therapies will likely ultimately integrate strategies that combine immunotherapy approaches and immune-modulating drugs, in order to maximize their antitumor activity. Citation Format: Sandrine Valsesia-Wittmann, Beatrice Clemenceau, Anne-Catherine Jallas, Jean-Yves Blay, Aurelien Marabelle, Christophe Caux, Henri Vie. Overcoming therapeutic MAb resistance in agressive HER2 positive breast carcinomas by adoptive immunotherapy using optizimed effectors cells. [abstract]. In: Proceedings of the AACR Special Conference: Tumor Immunology and Immunotherapy: A New Chapter; December 1-4, 2014; Orlando, FL. Philadelphia (PA): AACR; Cancer Immunol Res 2015;3(10 Suppl):Abstract nr A14.
Accuracy and conditioning of the method of moments for the 2D EFIE (1999)

The condition number scaling for a conducting strip and resonant cavity for the transverse magnetic (TM) and transverse electric (TE) polarizations is given. Three sources of ill-conditioning are identified: increasing discretization density, surface wave self-coupling, and resonance. Changing to a second-kind integral equation eliminates the first two sources, but real resonances still cause ill-conditioning.
Data from MicroRNA-21 Knockdown Disrupts Glioma Growth <i>In vivo</i> and Displays Synergistic Cytotoxicity with Neural Precursor Cell–Delivered S-TRAIL in Human Gliomas (2023)

&lt;div&gt;Abstract&lt;p&gt;Despite the development of new glioma therapies that allow for tumor-targeted &lt;i&gt;in situ&lt;/i&gt; delivery of cytotoxic drugs, tumor resistance to apoptosis remains a key impediment to effective treatment. Mounting evidence indicates that microRNAs (miRNA) might play a fundamental role in tumorigenesis, controlling cell proliferation and apoptosis. In gliomas, microRNA-21 (miR-21) levels have been reported to be elevated and their knockdown is associated with increased apoptotic activity. We hypothesized that suppression of miR-21 might sensitize gliomas for cytotoxic tumor therapy. With the use of locked nucleic acid (LNA)-antimiR-21 oligonucleotides, bimodal imaging vectors, and neural precursor cells (NPC) expressing a secretable variant of the cytotoxic agent tumor necrosis factor–related apoptosis inducing ligand (S-TRAIL), we show that the combined suppression of miR-21 and NPC-S-TRAIL leads to a synergistic increase in caspase activity and significantly decreased cell viability in human glioma cells &lt;i&gt;in vitro&lt;/i&gt;. This phenomenon persists &lt;i&gt;in vivo&lt;/i&gt;, as we observed complete eradication of LNA-antimiR-21–treated gliomas subjected to the presence of NPC-S-TRAIL in the murine brain. Our results reveal the efficacy of miR-21 antagonism in murine glioma models and implicate miR-21 as a target for therapeutic intervention. Furthermore, our findings provide the basis for developing combination therapies using miRNA modulation and cytotoxic tumor therapies. [Cancer Res 2007;67(19):8994–9000]&lt;/p&gt;&lt;/div&gt;
Analysis of Backbone Hydrogen Bonding in a β-Turn of Staphylococcal Nuclease (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTAnalysis of Backbone Hydrogen Bonding in a β-Turn of Staphylococcal NucleaseInjae Shin, Alice Y. Ting, and Peter G. SchultzView Author Information Howard Hughes Medical Institute Department of Chemistry, University of California Lawrence Berkeley National Laboratory Berkeley, California 94720 Cite this: J. Am. Chem. Soc. 1997, 119, 51, 12667–12668Publication Date (Web):December 24, 1997Publication History Received12 August 1997Published online24 December 1997Published inissue 1 December 1997https://pubs.acs.org/doi/10.1021/ja972820qhttps://doi.org/10.1021/ja972820qrapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views210Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Amides,Monomers,Noncovalent interactions,Organic compounds,Peptides and proteins Get e-Alerts
Dopaminergic Modulation of Cortical Inputs during Maturation of Adult-Born Dentate Granule Cells (2011)

Adult neurogenesis, a particular form of plasticity in the adult brain, is under dynamic control of neuronal activity mediated by various neurotransmitters. Despite accumulating evidence suggesting that the neurotransmitter dopamine (DA) regulates proliferation of neural precursor cells in the neurogenic zones, whether and how it acts on newly generated neurons that integrate into the established network remains unknown. Using patch-clamp recordings from retrovirus-labeled newborn hippocampal dentate granule cells (DGCs) in acute mouse brain slices, we found that DA not only caused a long-lasting attenuation of medial perforant path (MPP) inputs to the young DGCs, but also decreased their capacity to express long-term potentiation (LTP). In contrast, DA suppressed MPP transmission to mature DGCs to a similar extent but did not influence their LTP expression. This difference was linked to activation of distinct subtypes of DA receptors in DGCs at different developmental stages. Our observations suggest that DA is particularly effective in modulating the activities of hyperexcitable young neurons, which may have important implications for the dentate function as a filter for incoming information to the hippocampus.
Up-regulation of mucin secretion in HT29-MTX cells by the pro-inflammatory cytokines tumor necrosis factor-alpha and interleukin-6. (2001)

The pro-inflammatory cytokines IL-6 and TNF-alpha have been implicated in the pathogenesis of otitis media with effusion (OME). A disease where goblet cells proliferate in a modified respiratory epithelium, leading to the accumulation of a mucin-rich effusion in the middle ear cleft. The MUC5AC and MUC5B mucin gene products have been identified as components of these effusions. To determine the effect of IL-6 and TNF-alpha on MUC5AC and MUC5B secretion we have used HT29-MTX goblet cells, which secrete both types of mucins. MUC5AC and MUC5B mucin secretion was measured by an enzyme-linked immunosorbent assay (ELISA) using a specific monoclonal antibody NCL-HGM-45M1 and polyclonal antiserum TEPA, respectively. Time response (0-72 hours) and dose response (1.5-150 ng/ml) studies were carried out. IL-6 and TNF-alpha stimulated MUC5AC and MUC5B mucin secretion in a time dependent manner, both in pre-confluent and post-confluent cells. IL-6 (15 ng/ml and 20 ng/ml) produced a low and prolonged stimulation of mucin secretion that persisted for 72 hours, with peak response at 24 hours after induction. The IL-6-mediated mucin secretion at 24 hours was concentration-dependent, with a maximal effect at 15 ng/ml. TNF-alpha (20 ng/ml) induced rapid stimulation of mucin secretion within the first 24 hours, with peak response at 7 hours after induction. IL-6 and TNF-alpha exposure significantly increased MUC5AC secretion, but not MUC5B secretion. Maximal levels of cytokine-induced mucin secretion were detected in pre-confluent cells that showed one and a half- and two-fold increases in MUC5AC secretion after IL-6 and TNF-alpha stimulation, respectively, in comparison with post-confluent cells. The results presented here suggest that IL-6 and TNF-alpha generate a differential up-regulation of mucin secretion and thus contribute to the expression of mucin genes in inflammatory responses.
An active and selective alkane isomerization catalyst: iron- and platinum-promoted tungstated zirconia (2001)

Addition of iron sulfate to Pt-promoted tungstated zirconia increases the activity and selectivity of the catalyst for isomerization of n-pentane in the presence of H2; selectivities >98% have been observed.
Mobile C‐arm cone‐beam CT for guidance of spine surgery: Image quality, radiation dose, and integration with interventional guidance (2011)

Intraoperative CBCT using a high-performance mobile C-arm prototype demonstrates image quality suitable to guidance of spine surgery, with task-specific protocols providing an important basis for minimizing radiation dose, while maintaining image quality sufficient for surgical guidance. Images demonstrate a significant advance in spatial resolution and soft-tissue visibility, and CBCT guidance offers the potential to reduce fluoroscopy reliance, reducing cumulative dose to patient and staff. Integration with a surgical guidance system demonstrates precise tracking and visualization in up-to-date images (alleviating reliance on preoperative images only), including detection of errors or suboptimal surgical outcomes in the operating room.
An effective algorithm for parallelizing sort merge joins in the presence of data skew (2002)

A parallel sort-merge-join algorithm that uses a divide-and-conquer approach to address the data skew problem is proposed. The algorithm adds an extra scheduling phase to the usual sort, transfer and join phases. During the scheduling phase, a parallelizable optimization algorithm, using the output of the sort phase, attempts to balance the load across the multiple processors in the subsequent join phase. The algorithm naturally identifies the largest skew elements and assigns each of them to an optimal number of processors. Assuming a Zipf-like distribution for data skew, the algorithm is shown to achieve very good load balancing for the join phase in a CPU-bound environment and to be very robust relative to the degree of data skew and the total number of processors.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The Association Between Total and Positive Lymph Node Counts, and Disease Progression in Clinically Localized Prostate Cancer (2006)

Nodal disease increased the risk of progression. Extensive lymphadenectomy enhances the accuracy of surgical staging. However, we were unable to determine that removing more nodes improves freedom from BCR uniformly. Since the proportion of patients with prostate cancer with positive nodes is low, the value of extensive lymphadenectomy requires a multi-institutional, randomized clinical trial.
Perivascular Endothelial Implants Inhibit Intimal Hyperplasia in a Model of Arteriovenous Fistulae: A Safety and Efficacy Study in the Pig (2002)

Vascular access complications are a major problem in hemodialysis patients. Native arteriovenous fistulae, historically the preferred mode of access, have a patency rate of only 60% at 1 year. The most common mode of failure is due to progressive stenosis at the anastomotic site. We have previously demonstrated that perivascular endothelial cell implants inhibit intimal thickening following acute balloon injury in pigs and now seek to determine if these implants provide a similar benefit in the chronic and more complex injury model of arteriovenous anastomoses. Side-to-side femoral artery-femoral vein anastomoses were created in 24 domestic swine and the toxicological, biological and immunological responses to allogeneic endothelial cell implants were investigated 3 days and 1 and 2 months postoperatively. The anastomoses were wrapped with polymer matrices containing confluent porcine aortic endothelial cells (PAE; n = 14) or control matrices without cells (n = 10). PAE implants significantly reduced intimal hyperplasia at the anastomotic sites compared to controls by 68% (p < 0.05) at 2 months. The beneficial effects of the PAE implants were not due to differences in the rates of reendothelialization between the groups. No significant immunological response to the allogeneic endothelial cells that impacted on efficacy was detected in any of the pigs. No apparent toxicity was observed in any of the animals treated with endothelial implants. These data suggest that perivascular endothelial cell implants are safe and reduce early intimal hyperplasia in a porcine model of arteriovenous anastomoses.
In Situ Detection of Endogenous HIV Activation by Dynamic Nuclear Polarization NMR and Flow Cytometry (2020)

We demonstrate for the first time in-cell dynamic nuclear polarization (DNP) in conjunction with flow cytometry sorting to address the cellular heterogeneity of in-cell samples. Utilizing a green fluorescent protein (GFP) reporter of HIV reactivation, we correlate increased <sup>15</sup>N resonance intensity with cytokine-driven HIV reactivation in a human cell line model of HIV latency. As few as 10% GFP+ cells could be detected by DNP nuclear magnetic resonance (NMR). The inclusion of flow cytometric sorting of GFP+ cells prior to analysis by DNP-NMR further boosted signal detection through increased cellular homogeneity with respect to GFP expression. As few as 3.6 million <sup>15</sup>N-labeled GFP+ cells could be readily detected with DNP-NMR. Importantly, cell sorting allowed for the comparison of cytokine-treated GFP+ and GFP- cells in a batch-consistent way. This provides an avenue for normalizing NMR spectral contributions from background cellular processes following treatment with cellular modulators. We also demonstrate the remarkable stability of AMUPol (a nitroxide biradical) in Jurkat T cells and achieved in-cell enhancements of 46 with 10 mM AMUPol, providing an excellent model system for further in-cell DNP-NMR studies. This represents an important contribution to improving in-cell methods for the study of endogenously expressed proteins by DNP-NMR.
Femtosecond laser writing of Volume Bragg Gratings in silver-containing glasses for VIS-NIR applications (2021)

International audience
Deposition of PtxRu1−x Catalysts for Methanol Oxidation in Micro Direct Methanol Fuel Cells (2008)

Abstract Platinum‐ruthenium electrodes (Pt x Ru 1‐x ) have been prepared by electrochemical and electroless deposition and investigated as catalysts for the oxidation of methanol in acidic solutions. Pt x Ru 1‐x deposits were electrochemically deposited from acidic chloride electrolytes at potentials between −0.46 and 0.34 V (vs. NHE). The composition of the electrodeposit was estimated by energy dispersive X‐ray spectroscopy and is a strong function of the electrode potential. An empirical model for the deposition process is presented and kinetic parameters are estimated and discussed. Also, the methanol oxidation activity of the Pt x Ru 1‐x catalysts was characterized by cyclic voltammetry in 1.0 M CH 3 OH, 1.0 M H 2 SO 4 solutions. Electroless Pt x Ru 1‐x samples were prepared in a modified Leaman bath with hydrazine dihydrochloride as the reducing agent. The kinetic results for the electrochemical deposition of Pt x Ru 1‐x were directly applied and the deposition potential was estimated as approximately 0.40 V.
Correction to Sulforaphane Potentiates the Efficacy of Imatinib against Chronic Leukemia Cancer Stem Cells through Enhanced Abrogation of Wnt/b-Catenin Function (2014)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to Sulforaphane Potentiates the Efficacy of Imatinib against Chronic Leukemia Cancer Stem Cells through Enhanced Abrogation of Wnt/b-Catenin FunctionLi-Ching Lin, Chi-Tai Yeh, Chia-Chun Kuo, Chi-Ming Lee, Gow-Chin Yen, Liang-Shun Wang, Chih-Hsiung Wu, Wei-Chung Vivian Yang, and Alexander T. H. Wu*Cite this: J. Agric. Food Chem. 2014, 62, 11, 2457Publication Date (Web):March 10, 2014Publication History Published online10 March 2014Published inissue 19 March 2014https://pubs.acs.org/doi/10.1021/jf501087uhttps://doi.org/10.1021/jf501087ucorrectionACS PublicationsCopyright © 2014 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views301Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (772 KB) Get e-Alertsclose Get e-Alerts