gebhart/patrepeval huggingface dataset:
The RNA-Binding Protein, ZFP36L2, Influences Ovulation and Oocyte Maturation (2020)

ZFP36L2 protein destabilizes AU-rich element-containing transcripts and has been implicated in female fertility. In the C57BL/6NTac mouse, a mutation in Zfp36l2 that results in the decreased expression of a form of ZFP36L2 in which the 29 N-terminal amino acid residues have been deleted, ΔN-ZFP36L2, leads to fertilized eggs that arrest at the two-cell stage. Interestingly, homozygous ΔN-Zfp36l2 females in the C57BL/6NTac strain release 40% fewer eggs than the WT littermates (Ramos et al., 2004), suggesting an additional defect in ovulation and/or oocyte maturation. Curiously, the same ΔN-Zfp36l2 mutation into the SV129 strain resulted in anovulation, prompting us to investigate a potential problem in ovulation and oocyte maturation. Remarkably, only 20% of ΔN-Zfp36l2 oocytes in the 129S6/SvEvTac strain matured ex vivo, suggesting a defect on the oocyte meiotic maturation process. Treatment of ΔN-Zfp36l2 oocytes with a PKA inhibitor partially rescued the meiotic arrested oocytes. Furthermore, cAMP levels were increased in ΔN-Zfp36l2 oocytes, linking the cAMP/PKA pathway and ΔN-Zfp36l2 with meiotic arrest. Since ovulation and oocyte maturation are both triggered by LHR signaling, the downstream pathway was investigated. Adenylyl cyclase activity was increased in ΔN-Zfp36l2 ovaries only upon LH stimulation. Moreover, we discovered that ZFP36L2 interacts with the 3′UTR of LHR mRNA and that decreased expression levels of Zfp36l2 correlates with higher levels of LHR mRNA in synchronized ovaries. Furthermore, overexpression of ZFP36L2 decreases the endogenous expression of LHR mRNA in a cell line. Therefore, we propose that lack of the physiological down regulation of LHR mRNA levels by ZFP36L2 in the ovaries is associated with anovulation and oocyte meiotic arrest.
α5 Subunit-containing GABAA receptors mediate a slowly decaying inhibitory synaptic current in CA1 pyramidal neurons following Schaffer collateral activation (2009)

GABA(A) receptors that contain the alpha5 subunit (alpha5GABA(A)Rs) are highly expressed in the hippocampus, and have been implicated in learning and memory processes. They generate a tonic form of inhibition that regulates neuronal excitability. Recently it was shown that alpha5GABA(A)Rs also contribute to slow phasic inhibition of CA1 pyramidal neurons following local stimulation in the stratum lacunosum moleculare. However, it is unknown whether alpha5GABA(A)Rs can also be recruited indirectly by stimulation of Schaffer collaterals. Here, we studied GABAergic currents evoked by stimulation in the stratum radiatum of CA1 in the presence and absence of CNQX to block AMPA receptor-mediated excitation. We tested their sensitivity to gabazine and two drugs acting at the benzodiazepine site of alpha1/alpha2/alpha3 or alpha5GABA(A)Rs (400 nM zolpidem and 20 nM L-655,708, respectively). IPSCs evoked by stimulation in the stratum radiatum in the presence of CNQX were potentiated by zolpidem, blocked by 1 muM gabazine and were relatively insensitive to L-655,708 consistent with the lack of alpha5GABA(A)Rs. In contrast, IPSCs evoked by stimulation of Schaffer collaterals had a significant gabazine-insensitive component. This component was attenuated by L-655,708 and enhanced by burst stimulation. Furthermore, the L-655,708-sensitive current was absent in recordings from mice lacking alpha5GABA(A)Rs (gabra5(-/-) mice). These results show that alpha5GABA(A)R-mediated phasic inhibition is activated by the Schaffer collateral pathway and provide evidence for activity pattern-dependent participation of alpha5GABA(A)Rs in inhibition.
Altered thermoregulation in ambulatory schizophrenia patients: A naturalistic study (2008)

Ambulatory schizophrenia patients without a concomitant infectious/inflammatory process exhibit altered thermoregulation manifested by a substantial (about 0.2 C) and significantly lower oral temperature compared to healthy comparison subjects as well as a potential exaggerated increase in oral temperature during transitory infectious/inflammatory processes. The relevance of these phenomena to the pathophysiology of schizophrenia as well as the potential immune-mediated pathologies in schizophrenia merit further investigation.
Bioinspired Engineering of a Bacterium‐Like Metal–Organic Framework for Cancer Immunotherapy (2020)

Abstract Bacteria‐mediated tumor therapy (BMTT) has been known for decades; however, its clinical use is inhibited by its association with infections. To address this issue, a spiky, bacterium‐like metal–organic framework (MOF), which can replicate the functional responses of BMTT without its adverse side‐effects, is proposed. MOFs are synthesized in a solvothermal reaction of aluminum sulfate, ruthenium chloride hydrate, and 2‐aminoterephthalic acid; they have a spherical morphology or many nanospikes on their surfaces, depending on the reaction temperature. Both spherical and spiky MOFs can function as photothermal agents, converting absorbed optical energy into local heat. Owing to their higher surface area of interaction, spiky MOFs are more easily phagocytosed by macrophages than are spherical MOFs, strengthening their immune responses. Moreover, when injected intratumorally, spiky MOFs reside significantly longer than spherical ones, enabling their use in repeated photothermal treatments. The combination of in situ vaccination with intratumorally injected bacterium‐like MOFs under exposure to an near‐infrared laser and the immune checkpoint blockade of systemically administered αPD‐1 is evaluated in tumor‐bearing mice. The results indicate that the checkpoint blockade acts synergistically with in situ vaccination to provide diverse antitumor functions of BMTT, destroying a primary tumor and suppressing tumor recurrence and metastasis.
Undersøkelse over kvalitet av fisk lagret i kjølt sjøvann og i is. I. (1981)

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Finite element prediction of surface strain and fracture strength at the distal radius (2011)

To better understand the mechanisms underlying distal radius fracture we have developed finite element models to predict radius bone strain and fracture strength under loading conditions simulating a fall. This study compares experimental surface strains and fracture loads of the distal radius with specimen-specific finite element models to validate our model-generating algorithm. Five cadaveric forearms were instrumented with strain gage rosettes, loaded non-destructively to 300 N, and subsequently loaded until failure. Finite element models were created from computed tomography data; three separate density-elasticity relationships were examined. Fracture strength was predicted for three specimens that failed at the distal radius using six different failure theories. The density-elasticity relationship providing the strongest agreement between measured and predicted strains had a correlation of r=0.90 and a root mean squared error 13% of the highest measured strain. Mean absolute percent error (11.6%) between measured and predicted fracture loads was minimized with Coulomb-Mohr failure theory and a tensile-compressive strength ratio of 0.5. These results suggest that our modeling method is a suitable candidate for the in vivo assessment of distal radius bone strain and fracture strength under fall type loading configurations.
Nanotribological effects of silicone type, silicone deposition level, and surfactant type on human hair using atomic force microscopy. (2006)

The atomic/friction force microscope (AFM/FFM) has recently become an important tool for studying the micro/nanoscale structure and tribological properties of human hair. Of particular interest to hair and beauty care science is how common hair-care materials, such as conditioner, deposit onto and change hair's tribological properties, since these properties are closely tied to product performance. Since a conditioner is a complex network of many different ingredients (including silicones for lubrication and cationic surfactants for static control and gel network formulation), studying the effects of these individual components can give insight into the significance each has on hair properties. In this study, AFM/FFM is used to conduct nanotribological studies of surface roughness, friction force, and adhesive forces as a function of silicone type, silicone deposition level, and cationic surfactant type. Changes in the coefficient of friction as a result of soaking hair in de-ionized water are also discussed.
Long wavelength infrared streak camera (2002)

An atomic streak camera has been constructed with a spectral range from 3-300 THz and a 2 ps time resolution. Gas-phase Rydberg atoms are used as an infrared sensitive photocathode. Prompt electron emission from the autoionizing Rydberg atoms is obtained when red Stark states are selected.
Partial results in database systems (2014)

As the size and complexity of analytic data processing systems continue to grow, the effort required to mitigate faults and performance skew has also risen. However, in some environments we have encountered, users prefer to continue query execution even in the presence of failures (e.g., the unavailability of certain data sources), and receive a "partial" answer to their query. We explore ways to characterize and classify these partial results, and describe an analytical framework that allows the system to perform coarse to fine-grained analysis to determine the semantics of a partial result. We propose that if the system is equipped with such a framework, in some cases it is better to return and explain partial results than to attempt to avoid them.
High elasticity of CsPbBr3 perovskite nanowires for flexible electronics (2021)

Due to the enhanced ambient structural stability and excellent optoelectronic properties, all-inorganic metal halide perovskite nanowires have become one of the most attractive candidates for flexible electronics, photovoltaics and optoelectronics. Their elastic property and mechanical robustness become the key factors for device applications under realistic service conditions with various mechanical loadings. Here, we demonstrate that high tensile elastic strain (∼ 4% to ∼ 5.1%) can be achieved in vapor-liquid-solid-grown single-crystalline CsPbBr3 nanowires through in situ scanning electron microscope (SEM) buckling experiments. Such high flexural elasticity can be attributed to the structural defect-scarce, smooth surface, single-crystallinity and nanomechanical size effect of CsPbBr3 nanowires. The mechanical reliability of CsPbBr3 nanowire-based flexible photodetectors was examined by cyclic bending tests, with no noticeable performance deterioration observed after 5,000 cycles. The above results suggest great application potential for using all-inorganic perovskite nanowires in flexible electronics and energy harvesting systems.
Dynamic Density Topological Structure Generation for Real-Time Ladder Affordance Detection (2019)

This paper presents a method with dynamic density topological structure generation for low-cost real-time vertical ladder detection from 3D point cloud data. Dynamic Density Growing Neural Gas (DD-GNG) is proposed to generate a dynamic density of the topological structure. The density of the structure and the number of nodes will be increased in the targeted object area. Feature extraction model is required to classify suspected objects for being processed in the next time process. After that, rungs of the vertical ladder is processed using an inlier-outlier method. Thus, the ladder detection model represents the ladder with a set of nodes and edges. Next, affordance detection is processed for detecting the feasible grasped location. To validate the effectiveness of the proposed method, a series of experiments are conducted on a 4-legged robot with a non-GPU board for real-time vertical ladder detection and climbing to validate the effectiveness of the proposed method. Results show that our proposed method able to detect and track the ladder structure in real-time with a much lower computational cost. The affordance of the ladder provides safety information for robot grasping.
Successors of ArF Water-Immersion Lithography: EUV Lithography, Multi-e-beam Maskless Lithography, or Nanoimprint? (2008)

The <i>Journal of Micro/Nanopatterning, Materials, and Metrology</i> (JM3) publishes peer-reviewed papers on the core enabling technologies that address the patterning needs of the electronics industry.
Stabilization of Graphene Sheets by a Structured Benzene/Hexafluorobenzene Mixed Solvent (2012)

Applications requiring pristine graphene derived from graphite demand a solution stabilization method that utilizes an easily removable media. Using a combination of molecular dynamics simulations and experimental techniques, we investigate the solublization/suspension of pristine graphene sheets by an equimolar mixture of benzene and hexafluorobenzene (C(6)H(6)/C(6)F(6)) that is known to form an ordered structure solidifying at 23.7 °C. Our simulations show that the graphene surface templates the self-assembly of the mixture into periodic layers extending up to 30 Å from both sides of the graphene sheet. The solvent structuring is driven by quadrupolar interactions and consists of stacks of alternating C(6)H(6)/C(6)F(6) molecules rising from the surface of the graphene. These stacks result in density oscillations with a period of about 3.4 Å. The high affinity of the 1:1 C(6)H(6)/C(6)F(6) mixture with graphene is consistent with observed hysteresis in Wilhelmy plate measurements using highly ordered pyrolytic graphite (HOPG). AFM, SEM, and TEM techniques verify the state of the suspended material after sonication. As an example of the utility of this mixture, graphene suspensions are freeze-dried at room temperature to produce a sponge-like morphology that reflects the structure of the graphene sheets in solution.
Supplementary Table 4 from Genome-Wide Promoter Analysis Uncovers Portions of the Cancer Methylome (2023)

Supplementary Table 4 from Genome-Wide Promoter Analysis Uncovers Portions of the Cancer Methylome
Highly efficient in-plane type filtering device in two-dimensional photonic crystal slab (2004)

We propose an in-plane type filtering device based on two-dimensional photonic crystal slab, which has high drop efficiency and less sensitivity to structural fluctuations. Excellent device performance is demonstrated by numerical simulations.
Synthesis of pyrano[4,3-b]indoles as conformationally restricted analogs of the serotonin antagonist ICS 205-930 and as precursors to 2-vinylindoles (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of pyrano[4,3-b]indoles as conformationally restricted analogs of the serotonin antagonist ICS 205-930 and as precursors to 2-vinylindolesJohn E. Macor, Kevin Ryan, and Michael E. NewmanCite this: J. Org. Chem. 1989, 54, 20, 4785–4795Publication Date (Print):September 1, 1989Publication History Published online1 May 2002Published inissue 1 September 1989https://doi.org/10.1021/jo00281a018RIGHTS & PERMISSIONSArticle Views820Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Acoustic clustering and adaptation for robust speech recognition (1997)

We describe an algorithm based on acoustic clustering and acoustic adaptation to significantly improve speech recognition performance. The method is particularly useful when speech from multiple speakers is to be recognized and the boundary between speakers is not known. We assume that each test data segment is relatively homogeneous with respect to the acoustic background and speaker. These segments are then grouped using an agglomerative acoustic clustering algorithm. The idea is to group together all test segments that are acoustically similar. The speech recognition models are then adapted separately to each test data cluster. Finally these adapted models are used to recognize the data from that cluster. This algorithm was used in SRI’s system for the 1996 DARPA Hub4 partitioned evaluation. Experimental results are presented on the 1996 H4 development data set. It was found that an improvement of 9.5% was achieved by using this algorithm.
IgE reactivity to profilin in Platanus acerifolia pollen-sensitized subjects with plant-derived food allergy. (2004)

The clinical association observed between Platanus acerifolia pollen and plant-derived food could be explained by the in vitro IgE cross-reactivity detected by EAST-inhibition. However, it appears that neither P. acerifolia profilin nor the two major allergens described (Pla a 1 and Pla a 2) can explain such a strong cross-reactivity.
Use of delayed electroluminescence as a tool to investigate the emission mechanism of phosphorescent organic light emitting devices (2012)

Delayed electroluminescence (Delayed EL) measurements are used to investigate the emission mechanism in typical Phosphorescent Organic Light Emitting Devices (PHOLEDs). In this work, emission mechanism of PHOLED based on CBP (4,4'-bis(carbazol-9-yl)biphenyl : Ir(ppy)<sub>3</sub> (Tris(2-phenylpyridine)iridium(III)) host:guest system is studied. The technique is used to understand whether the EL emission arises from charge recombination directly on guest sites or from recombination on host material followed by host to guest energy transfer. The results show that the emission mechanism changes with the emission layer (EML) thickness. In the case of devices with a thick EML, strong host triplet-triplet annihilation (TTA) is observed, suggesting the presence of significant energy transfer from host to the guest. For the case of devices with thin EML, on the other hand, host TTA is insignificant, suggesting that direct charge trapping on the guest is the main emission mechanism. The results also show that the thickness of the hole transport layer (HTL) has negligible effect on the emission mechanism of PHOLED, showing that the emission mechanism mainly depends on the EML.
Electrically switchable holographic Bragg gratings (1992)

Bragg gratings have been recorded holographically in photopolymers doped with nematic liquid crystals. Gratings are enhanced with liquid crystal doping, as evidenced by increased diffraction efficiency. Microscopy studies support the theory that microscopic phases of liquid crystals are formed during the curing process. In situ monitoring of diffraction efficiency during photocuring allows a study of the grating formation kinetics as a function of laser power. At 0.58 mW/cm 2 , 90% of maximum diffraction efficiency has been achieved in 2.2 s. Measurable diffraction occurs in 250 ms. Post-irradiation curing has also been observed. Diffraction efficiency at 633 nm of fully cured samples is as high as 60% for a Bragg angle of 57.5° (2700 lines/mm grating). The diffraction efficiency can be controlled by the application of ac voltages. The Bragg diffraction peak has been observed to completely vanish at approximately 300 V rms. This indicates an electro-optic control of the refractive index modulation formed by the microscopic liquid crystal phases.
[Urine stream pressure and urethral energy loss]. (1981)

In the present paper is reported on the estimation of several physical parameters of the urinary stream leaving the urethra in boys. Normal values which we determined in 33 boys could be compared with the measuring values in patients with subvesical disturbances of the passage. Proximal stenoses are characterized by a low residual energy of the urinary stream. In distal stenoses it is normal to increased. The clinical importance may result from the possibility of the diagnosis of disturbances in which quickly is to be reckoned with the development of secondary changes of the upper urinary tract with the help of a non-invasive method. The calculation of the urethral loss of energy allows further informations. It demands a suprapubic puncture of the urinary bladder for measuring the pressure.
ChemInform Abstract: Remarkable Cumulative Stereoselectivity in Cyclopropanation with Supramolecular Cu(I) Catalytic Complexes. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
LabVIEW Machine Vision Applications (2014)

Machine vision applications are now essential to many different industries such as manufacturing, semiconductor, surveillance, automobile, and medical applications. In this chapter, a few examples of machine vision applications are discussed. In the field of semiconductor industry, machine vision has been used for inspection, positioning, and alignment of substrates. In the auto industry, machine vision measurement has been used to increase assembly accuracy, performance, and reliability. In the medical, pharmaceutical, and bio areas, vision systems can be useful tools for analysis and automation. Defects can be detected during the manufacturing process. Machine vision can measure the dimensions at a specific part of an object. Modern higher end document and graphics printers often have embedded vision systems to monitor four or more color separation and general feature placement as well as color matching control.
Molecular Lipopolysaccharide Di-Vaccine Protects from Shiga-Toxin Producing Epidemic Strains of Escherichia coli O157:H7 and O104:H4 (2022)

Di-vaccine induced both systemic and intestinal anti-colonization immunity in mice simultaneously against two highly virulent human STEC strains. The possibility of creating a multivalent STEC vaccine based on safe Ac<sub>3</sub>-S-LPS seems to be especially promising due to a vast serotype diversity of pathogenic <i>E. coli</i>.