gebhart/patrepeval huggingface dataset:
Utility of Single-Item Questions to Assess Physical Inactivity in Patients with Chronic Heart Failure (2020)

There might be utility in the single SR question for high-specificity screening of large populations to identify physically inactive patients in order to assign therapeutic interventions efficiently where resources are limited.
Acute withdrawal syndrome related to the administration of analgesic and sedative medications in adult intensive care unit patients (1998)

These results suggest that mechanically ventilated adult patients with extended ICU care (> or =7 days) who receive large doses of analgesic and sedative medications are at risk for acute withdrawal syndromes during drug weaning. The association between ARDS and withdrawal syndrome, combined with the observation that withdrawal syndromes were also associated with the use of neuromuscular blocking agents and prolonged mechanical ventilation, suggests that patients with ARDS may be more likely to receive high doses of analgesic and sedative medications, and are therefore at increased risk for withdrawal syndrome.
Rho/SRF Inhibitor Modulates Mitochondrial Functions (2022)

CCG-1423 is a Rho A pathway inhibitor that has been reported to inhibit Rho/SRF-mediated transcriptional regulation. Serum response factor and its cofactors, which include ternary complex factors and myocardin-related transcription factors, regulate various cellular functions. In this study, we observed that CCG-1423 modulates the mitochondrial functions. The effect of this small molecule drug was determined by measuring mitochondrial function using an XFe96 Analyzer and an Oxygraph 2k (O2k) high-resolution respirometer. CCG-1423 treatment significantly reduced oxidative phosphorylation in a dose-dependent manner. However, CCG-1423 increased the glycolytic rate. We also observed that histone 4 at lysine-16 underwent hyperacetylation with the treatment of this drug. Immunolabeling with F-actin and MitoTracker revealed the alteration in the actin cytoskeleton and mitochondria. Taken together, our findings highlight a critical role of CCG-1423 in inhibiting the transcription of SRF/p49 and PGC-1α, β, resulting in the downregulation of mitochondrial genes, leading to the repression of mitochondrial oxidative phosphorylation and overall ATP reduction. This study provides a better understanding of the effects of CCG-1423 on mitochondria, which may be useful for the assessment of the potential clinical application of CCG-1423 and its derivatives.
Responses of soil microorganisms to volatile exudates from germinating pea seeds (1985)

Responses of soil microorganisms to volatile exudates from germinating pea seeds of differing quality were determined. Germination of sclerotia of Rhizoctonia solani and Sclerotium rolfsii and subsequent hyphal growth were stimulated by exposure to volatiles from aged but not nonaged pea seeds. Hyphae grew preferentially toward aged seeds. In natural soil, bacterial and fungal populations showed significant increases after exposure to volatiles from aged seed. For example, Fusarium spp. and Pseudomonas spp. showed increases of 79 and 2200%, respectively, over their original population levels after a 48-h exposure to volatiles. Conversely, Pythium populations and associated seed-rotting potential of soil decreased in natural soils exposed to volatiles. In autoclaved soils infested with P. ultimum (PHP4), Pythium populations increased dramatically after exposure to volatiles from aged pea seeds. In soils infested with either soil fungi or bacteria in addition to P. ultimum, Pythium levels remained constant or decreased, respectively, with time of exposure. Exposure to the volatiles from aged pea seeds stimulated soil microbial activity. These results suggest that Pythium germlings, when unable to reach a host, are subjected to microbial antagonism in the presence of the native soil microflora. A decrease in cucumber seed rot coincided with decreases in Pythium numbers.
Supplementary Figure 1 from High Expression of Ligands for Chemokine Receptor CXCR2 in Alveolar Epithelial Neoplasia Induced by Oncogenic Kras (2023)

Supplementary Figure 1 from High Expression of Ligands for Chemokine Receptor CXCR2 in Alveolar Epithelial Neoplasia Induced by Oncogenic Kras
Diapause and anhydrobiosis in embryos of Artemia franciscana : metabolic depression, LEA proteins and water stress. (2013)

Metabolic depression is typically correlated with extended survival of environmental challenge and energy-limitation in early life stages of various invertebrates and vertebrates. Diapause is an ontogenetically-programmed reduction of development and often metabolism seen in many invertebrates. When embryos of Artemia franciscana enter the state of diapause, the overall metabolic depression is estimated to be greater than 99%. These embryos also contain trehalose and express multiple isoforms of Late Embryogenesis Abundant (LEA) proteins, constituents often present in a number of such anhydrobiotic animals. The mRNA levels for LEA proteins are highest in diapause and post-diapause embryos that possess desiccation tolerance, but are very low in desiccation-intolerant nauplius larvae. Stable transfection of human HepG2 cells with AfrLEA2 and AfrLEA3m was performed to evaluate the possibility of improved survivorship during drying. A trehalose transporter was used for intracellular loading of this disaccharide. LEA proteins improved desiccation tolerance in mammalian cells during acute drying and immediate rehydration.
Blastocoel cavity formation by preimplantation rat embryos in the presence of cyanide and other inhibitors of oxidative phosphorylation (1994)

The role of oxidative phosphorylation in blastocoel development in rats was determined by culturing morula stage embryos for 24 h in the presence of three inhibitors of ATP generation: cyanide, antimycin-A and 2,4-dinitrophenol (DNP). Rat morulae could form blastocysts in concentrations of cyanide that are toxic to the embryos of other mammals. Similar results were obtained with antimycin-A and DNP, although DNP reduced the number of blastocysts that formed. A non-invasive ultramicrofluorometric assay was used on single blastocysts and the glycolytic pathway was shown to be stimulated in the presence of these inhibitors. These results suggest that, uniquely among preimplantation embryos studied, the developing rat blastocyst does not have an absolute requirement for oxidative phosphorylation but may be able to compensate by increasing the amount of glucose consumed and metabolized by glycolysis. This pattern of metabolism may be related to the changing maternal environment during development, with blastocoel cavity formation and implantation taking place in increasingly anoxic conditions.
Common Mechanistic Pathways in Cancer and Heart Failure. A Scientific Roadmap on Behalf of the Translational Research Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) (2020)

The co-occurrence of cancer and heart failure (HF) represents a significant clinical drawback as each disease interferes with the treatment of the other. In addition to shared risk factors, a growing body of experimental and clinical evidence reveals numerous commonalities in the biology underlying both pathologies. Inflammation emerges as a common hallmark for both diseases as it contributes to the initiation and progression of both HF and cancer. Under stress, malignant and cardiac cells change their metabolic preferences to survive, which makes these metabolic derangements a great basis to develop intersection strategies and therapies to combat both diseases. Furthermore, genetic predisposition and clonal haematopoiesis are common drivers for both conditions and they hold great clinical relevance in the context of personalized medicine. Additionally, altered angiogenesis is a common hallmark for failing hearts and tumours and represents a promising substrate to target in both diseases. Cardiac cells and malignant cells interact with their surrounding environment called stroma. This interaction mediates the progression of the two pathologies and understanding the structure and function of each stromal component may pave the way for innovative therapeutic strategies and improved outcomes in patients. The interdisciplinary collaboration between cardiologists and oncologists is essential to establish unified guidelines. To this aim, pre-clinical models that mimic the human situation, where both pathologies coexist, are needed to understand all the aspects of the bidirectional relationship between cancer and HF. Finally, adequately powered clinical studies, including patients from all ages, and men and women, with proper adjudication of both cancer and cardiovascular endpoints, are essential to accurately study these two pathologies at the same time.
Seroprevalence and genital DNA prevalence of HPV types 6, 11, 16 and 18 in a cohort of young Norwegian women: study design and cohort characteristics (2007)

Given the high prevalence of HPV infection among young women with mostly single-type infection, and the fact that type-specific HPV screening is not recommended prior to the administration of the quadrivalent HPV vaccine, our data suggest the importance of widespread,rather than targeted, immunisation.
3D Lorentz force magnetic sensor using ultra-thin piezoresistive cantilevers (2013)

This paper reports on a Lorentz force-based triaxial magnetometer using three ultra-thin cantilevers. Instead of wholly fabricating 300nm-thick cantilever sets in plane, one of them is erected with a principle of residual stress of multi-layer to measure an out-of-plane magnetic field. In addition to realizing the highest sensitivity of ultra-thin piezo-resistive cantilevers, sensing characteristics of each direction are also comparable. With 10-mA direct excitation current, the sensor exhibits 3-axis magnetically sensing capability with an average sensitivity of ΔR/R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> =2.63 A <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> T <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> , resolution of 1mT, and power consumption less than 11mW. The proposed sensor is versatile enough to serve various demands of magnetically measuring works.
An embryonically expressed gene is a target for c-Myc regulation via the c-Myc-binding sequence. (1992)

We have used a subtraction/coexpression strategy involving two different tumors derived from c-myc-bearing transgenic mice to identify a gene that is a target for c-Myc regulation. The gene, expressed in certain embryonic and adult tissues and in several (but not all) c-myc-based tumors, bears a functional c-Myc-binding sequence located 3' to its transcription start site. This sequence is required for the binding of a nuclear protein complex which, by antibody analysis, includes c-Myc. This site is also required for expression of a reporter gene in chimeric constructs transfected into c-myc-overexpressing cells and, conversely, requires c-myc cotransfection for its enhanced expression in COS cells. Furthermore, transfection of c-myc blocks the normal down-regulation of this gene, which occurs in embryonic stem cells as they undergo differentiation. This target gene encodes an anonymous cDNA (ECA39) found previously to be amplified in a teratocarcinoma cell line.
Pseudospin-1 Physics of Photonic Crystals (2019)

We review some recent progress in the exploration of pseudospin-1 physics using dielectric photonic crystals (PCs). We show some physical implications of the PCs exhibiting an accidental degeneracy induced conical dispersion at the <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mrow> <mml:mi mathvariant="normal">Γ</mml:mi> </mml:mrow> </mml:math> point, such as the realization of zero refractive index medium and the zero Berry phase of a loop around the nodal point. The photonic states of such PCs near the Dirac-like point can be described by an effective spin-orbit Hamiltonian of pseudospin-1. The wave propagation in the positive, negative, and zero index media can be unified within a framework of pseudospin-1 description. A scale change in PCs results in a rigid band shift of the Dirac-like cone, allowing for the manipulation of waves in pseudospin-1 systems in much the same way as applying a gate voltage in pseudospin-1/2 graphene. The transport of waves in pseudospin-1 systems exhibits many interesting phenomena, including super Klein tunneling, robust supercollimation, and unconventional Anderson localization. The transport properties of pseudospin-1 systems are distinct from their counterparts in pseudospin-1/2 systems, which will also be presented for comparison.
Consensus-Based Distributed Filtering (2010)

We address the consensus-based distributed linear filtering problem, where a discrete time, linear stochastic process is observed by a network of sensors. We assume that the consensus weights are known and we first provide sufficient conditions under which the stochastic process is detectable, i.e. for a specific choice of consensus weights there exists a set of filtering gains such that the dynamics of the estimation errors (without noise) is asymptotically stable. Next, we provide a distributed sub-optimal filtering scheme based on optimizing an upper bound on a quadratic filtering cost. In the stationary case, we provide sufficient conditions under which this scheme converges; conditions expressed in terms of the convergence properties of a set of coupled Riccati equations. We continue with presenting a connection between the consensus-based distributed linear filter and the optimal linear filter of a Markovian jump linear system, appropriately defined. More specifically, we show that if the Markovian jump linear system is (mean square) detectable, then the stochastic process is detectable under the consensus-based distributed linear filtering scheme. We also show that the state estimate given by the optimal linear filter of a Markovian jump linear system appropriately defined can be seen as an approximation of the optimal average state estimate obtained using the consensus-based linear filtering scheme.
Influence of nonlinear intermolecular forces on the harmonic behavior of NEM resonators (2013)

This paper investigates the nonlinear effects introduced by the intermolecular forces on the static and harmonic behavior of electrostatically transduced nano-electromechanical (NEM) resonators using a lumped parameter model. We compute the pull-in parameters and study the full impact of the intermolecular forces on the spring softening effect, computing the non-linear terms using a Taylor expansion. We look at the impact on the resonance frequency and the maximum linear vibration amplitude of NEM resonators. From the set of case studies, we find that the non-linear intermolecular forces can have large effects on low stiffness structures. In particular, we report on a doubly clamped beam (DCB) resonator for which the intermolecular nonlinearity is expected to produce a 1% frequency shift and a 33% reduction in the maximum linear vibration amplitude.
Development and performance improvement of cognitive radio testbed on TV white space (2014)

Cognitive radio technologies have been studied for enhancing various aspects of wireless communication in terms of optimization of system parameters or dynamic spectrum access. Recently, testbed implementations have been frequently introduced to verify the feasibilities of these researches. The possibility on sharing TV bands with an unlicensed service is also proved by several platforms for data communication using TV white space. In this paper, we introduce a cognitive radio testbed which can improve the system capacity by using carrier aggregation functionality or 2×2 MIMO on the UHF TV bands. Detailed design and implementation issues focused on carrier aggregation are described. Finally, operating scenario and performance evaluation of our testbed are demonstrated.
Gene Defect in Hypodontia: Exclusion of EGF, EGFR, and FGF-3 as Candidate Genes (1996)

Hypodontia, congenital absence of one or a few permanent teeth without any systemic disorders, is regarded as an autosomally inherited dominant condition with varying expression and incomplete penetrance. Many studies have reported that the prevalence of hypodontia varies from 5% to 10% among European and Asian populations. The teeth most often missing are second premolars, upper lateral incisors, and lower central incisors. Consequently, we call this trait incisor-premolar hypodontia. Peg-shaped or strongly mesio-distally reduced upper lateral incisors demonstrate variation in the expression of the trait. The gene or genes causing incisorpremolar hypodontia are not known. We have begun the genetic mapping of hypodontia by using linkage analyses in seven Finnish three-generation families with 77 individuals, 31 affected with incisor-premolar hypodontia. As the first step, we studied the possibility of linkage between hypodontia and some candidate genes which have been suggested to have important functions during tooth development. Here we report the exclusion of EGF, EGFR, and FGF-3 loci as possible sites for gene mutation causing incisor-premolar hypodontia in our family material. Because of the close location of the FGF-3 and FGF-4 genes, the results also suggest the exclusion of the FGF-4 locus.
Striatal Delivery of rAAV-hAADC to Rats with Preexisting Immunity to AAV (2004)

We tested the hypotheses that initial immunization of rats with rAAV might limit subsequent transduction by rAAV-hAADC when stereotaxically infused into the striatum and that the level of inhibition would correlate with AAV neutralizing antibody titers. Immunohistochemical detection of AADC and analysis by stereology revealed that the control group (no immunization) had the greatest volume of distribution of AADC (20.32 +/- 2.03 mm3) (+/-SD). There was a 58% decrease in spread (8.46 +/- 3.67 mm3, P < 0.008) in the high-dose immunization group (5 x 10(10) vg rAAV-null). Transduction weakly correlated with preexisting titer levels of neutralizing antibody at the time of intrastriatal rAAV-hAADC infusion. Only rats with neutralizing antibody titers of 1:1208 +/- 332 had significantly decreased AADC transgene expression compared to the unimmunized control group. Immunohistochemistry on serial sections for inflammatory markers including GFAP, CD11b, CD4, and CD8a revealed normal morphology and no cellular infiltration, suggesting little immune reaction in the CNS. We conclude that rAAV vectors can transduce brain tissue in the context of preexisting immunity, but that efficiency of transduction declines significantly in the presence of very high titers of neutralizing antibodies. These results have important implications for gene therapy for CNS disorders.
Tailoring nanoarchitectonics to control the release profile of payloads (2016)

We demonstrate here that the control over the release rate of payloads and on the selectivity of the release can be achieved by designing nanomaterials with a hierarchical structure. Redox-responsive silica nanocapsules are first synthesized to allow for an accelerated release of the corrosion inhibitor 2-mercaptobenzothiazole as a payload upon chemical reduction and retarded release upon oxidation. In a second step, we embedded the nanocapsules into nanofibers by colloid-electrospinning, yielding a hierarchical composite structure. Remarkably, the encapsulation of the nanocapsules in the fibers provides two decisive advantages that are a higher selectivity of the release and a higher control over the release rate of payloads.
Speech coding with transform domain prediction (2017)

We show how model based prediction can be employed in the construction of a speech codec which operates entirely in the frequency domain of a Modified Discrete Cosine Transform (MDCT). The codec tools described in this paper are part of the Dolby AC-4 system standardized by ETSI and included in ATSC 3.0.
A Rapidly Growing Nodule and Dome-Shaped Yellow Papules on the Face—Quiz Case (2005)

A 62-year-old man presented with a nodule on his forehead that had grown rapidly in diameter over a 1-month period. His medical history included surgical removal of a right-sided colon cancer 10 years earlier. He had no family history of skin cancer or colon cancer.
Molecular mechanisms of medullary thyroid carcinoma: current approaches in diagnosis and treatment. (2008)

Medullary thyroid carcinoma is the most common cause of death among patients with multiple endocrine neoplasia (MEN) 2. Dominant-activating mutations in the RET proto-oncogene have been shown to have a central role in the development of MEN 2 and sporadic medullary thyroid cancer (MTC): about half of sporadic MTCs are caused by somatic genetic changes of the RET oncogene. Inactivating mutations of the same gene lead to Hirschprung disease and other developmental defects. Thus, RET genetic changes lead to phenotypes that largely depend on their location in the gene and the function and timing of developmental expression of the RET protein. The reproducibility of the phenotype caused by each RET genotype led to MEN 2/MTC being among the first conditions in Medicine where a drastic measure is applied to prevent cancer, following genetic testing: thyroidectomy is currently routinely done in young children that are carriers of MTC-predisposing RET mutations. RET inhibitors have been also developed recently and are used in various types of thyroid and other cancers. This report reviews the RET involvement in the etiology of MEN 2 and MTC and updates the therapeutic approach in preclinical and clinical studies.
Minimally Invasive Total Knee Arthroplasty (2004)

Bonutti, Peter M. MD; Mont, Michael A. MD; McMahon, Margo RN; Ragland, Phillip S. MD; Kester, Mark PHD Author Information
Minimal residual disease, long-term outcome, and IKZF1 deletions in children and adolescents with Down syndrome and acute lymphocytic leukaemia: a matched cohort study (2021)

Stichting Kinder Oncologisch Centrum Rotterdam and the Princess Máxima Center Foundation, NHMRC Australia, The Cancer Council NSW, Tour de Cure, Blood Cancer UK, UK Medical Research Council, Children with Cancer, Swedish Society for Pediatric Cancer, Swedish Childhood Cancer Fund, Danish Cancer Society and the Danish Childhood Cancer Foundation.
Preparation of size-controlled LiCoPO4particles by membrane emulsification using anodic porous alumina and their application as cathode active materials for Li-ion secondary batteries (2023)

Membrane emulsification using anodic porous alumina is an effective method for preparing monodisperse droplets with controlled sizes. In this study, membrane emulsification using anodic porous alumina was applied to the preparation of size-controlled particles composed of composite metal oxides. To obtain size-controlled composite metal oxide particles, membrane emulsification was performed using an aqueous solution containing a water-soluble monomer and metal salts as a dispersed phase. After the membrane emulsification, composite metal oxide particles were obtained by solidifying the droplets in a continuous phase and subsequent heat treatment. Here, as a demonstration of this process, the fabrication of size-controlled LiCoPO<sub>4</sub> particles, which are considered high-potential cathode active materials for Li-ion secondary batteries (LIBs), was investigated. The application of the obtained LiCoPO<sub>4</sub> particles as cathode active materials for LIBs was also investigated. The results of this study showed that LiCoPO<sub>4</sub> particles with controlled sizes could be fabricated on the basis of this process and that their cathode properties could be improved by optimizing the heat treatment conditions and particle sizes. According to this process, size-controlled particles composed of various metal oxides can be fabricated by changing the metal salt in the dispersed phase, and the resulting size-controlled particles are expected to be applied not only as cathode active materials for LIBs but also as components of various functional devices.