gebhart/patrepeval huggingface dataset:
Synthesis of Hexagonal-Shaped SnO2 Nanocrystals and SnO2@C Nanocomposites for Electrochemical Redox Supercapacitors (2008)

To realize a suitable supercapacitor nanomaterial, the recently developed technique of reaction under autogenic pressure at elevated temperature has been employed by us to synthesize SnO2 hexagonal nanocrystals and SnO2@C nanocomposites. The synthesis at different temperatures (viz. 500, 600, and 700 °C) yields three different composites. Characterization of these composites by various methods confirms the structural (XRD, Raman, FT-IR) and nanoparticulate (TEM, HRTEM) nature of the synthesized materials. TEM studies including HRTEM reveal that all the synthesized SnO2 and SnO2@C nanomaterials are highly crystalline with hexagonal shape. Cyclic voltammetric studies carried out to examine the capacitance of SnO2@C in 1 M H2SO4 show that the nanocomposite prepared at 700 °C has a maximum specific capacitance of 37.8 F/g at a scan rate of 5 mV/s.
The NBBS access node (1995)

Networking Broadband Services (NBBS) is an advanced wide-area-networking architecture that provides a rich set of services to support emerging applications for which quality of service and bandwidth reservation are critical, as well as legacy applications. The advanced features provided by the NBBS architecture require that each network node maintain a fully replicated topology database. As the size of the network increases, the network control costs at each network node become prohibitively high. The NBBS access node is a low-cost end node that introduces a hierarchical structure to the NBBS architecture, holding down network control costs while allowing the network to increase in size. The access node contains a subset of NBBS services. It is restricted to the periphery of the network and does not perform intermediate-node switching functions. It provides access to the NBBS backbone network by negotiating a relationship with an immediately attached network node (server network node) to obtain full NBBS services. In this paper, we discuss the requirements for the NBBS access node, examine the relationship between the access node and the server network node, and provide an overview of the access node architecture.
Imidazoquines as Antimalarial and Antipneumocystis Agents (2009)

Peptidomimetic imidazolidin-4-one derivatives of primaquine (imidazoquines) recently displayed in vitro activity against blood schizonts of a chloroquine-resistant strain of Plasmodium falciparum. Preliminary studies with a subset of such imidazoquines showed them to both block transmission of P. berghei malaria from mouse to mosquito and be highly stable toward hydrolysis at physiological conditions. This prompted us to have deeper insight into the activity of imidazoquines against both Plasmodia and Pneumocystis carinii, on which primaquine is also active. Full assessment of the in vivo transmission-blocking activity of imidazoquines, in vitro tissue-schizontocidal activity on P. berghei-infected hepatocytes, and in vitro anti-P. carinii activity is now reported. All compounds were active in these biological assays, with generally lower activity than the parent drug. However, imidazoquines' stability against both oxidative deamination and proteolytic degradation suggest that they will probably have higher oral bioavailability and lower hematotoxicity than primaquine, which might translate into higher therapeutic indexes.
The presence of FAC1 protein in Hirano bodies (1998)

We have previously reported that the FAC1 protein is contained in hippocampal structures that resemble Hirano bodies. Hirano bodies are cytoplasmic inclusions containing actin filaments that are numerous in the hippocampus of many Alzheimer's disease patients. FAC1 is a developmentally regulated protein that is localized to the cytoplasm of neurons during development and is predominately a nuclear protein in adult brain. In hippocampal sections from non-demented adults. Alzheimer's disease, and dementia with Lewy bodies patients. Hirano bodies were immunolabelled with antibodies to the FAC1 protein. Confocal laser microscopy demonstrated the presence of actin in FAC1 labelled Hirano bodies, and ultrastructural analysis confirmed the presence of a lattice structure within FAC1 labelled Hirano bodies. Numerous FAC1 immunoreactive swollen dendrites were also present in the hippocampus of Alzheimer's disease and dementia with Lewy bodies patients. Within any one case the total number of FAC1 positive swollen dendrites correlated with the total number of Hirano bodies, suggesting an association between the two structures. Thus, FAC1 protein is contained in Hirano bodies and swollen dendrites in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies.
Bandwidth variations in conformal infrared frequency selective surfaces (2007)

Infrared Frequency Selective Surfaces (FSS) have been demonstrated to control the spectral emissivity and reflectivity of a surface in the 3-6 mum band. These structures were designed using rigid substrates and with radiation only at normal incidence. Previous research has demonstrated conformal FSS transmission filters in the mid-infrared band. This paper will show the design and testing of an infrared FSS for control of spectral emissivity and reflectivity, and operating in the 3-6 mum band. The FSS performance will be demonstrated at angles of incidence from 0 to 30 degrees. Both square loop and loaded cross elements will be considered. The bandwidth of the loaded cross is shown to vary significantly with variation in angle of incidence while the bandwidth of the square loop is more stable.
Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase (2014)

Fragment-based drug design was successfully applied to maternal embryonic leucine zipper kinase (MELK). A low affinity (160 μM) fragment hit was identified, which bound to the hinge region with an atypical binding mode, and this was optimized using structure-based design into a low-nanomolar and cell-penetrant inhibitor, with a good selectivity profile, suitable for use as a chemical probe for elucidation of MELK biology.
Dimensional scaling effects on transport properties of p-i-n diodes (2007)

Device scaling has been a subject of research for both optoelectronics and electronics. In order to investigate the electronic properties of scaled devices we characterized lateral p-i-n structures using thin silicon on insulator (SOI) layers of varying dimension. With the help of these structures we try to explain the size dependencies on electronic transport properties. Further, we also studied different ways to fabricate silicon lines/fins.
Development of closed-loop implantable cooling system for epileptic seizure blockage (2008)

Hardware development and laboratory tests of an implantable closed-loop system for epileptic seizure blockage are reported. This approach (thermal suppression of abnormal brain electrical activity) is based on evidence derived mainly from animals and anecdotal reports from humans. An array of 7 needle-like probes (outer diameter ∼1 mm; length ∼20 mm) along with a SAW temperature sensor was designed using computer modeling for rapid (∼30 sec) cooling (∼37°C to ∼16°C) of 1 cubic inch of brain tissue (approximately the volume of the human amygdala and pes hippocampus). Theoretical studies and numerical modeling based on Pennes' equation were performed to optimize regional brain cooling. Experimental tests demonstrated good agreement with calculations. Changes in regional brain temperature associated with the onset of seizures are detected via the SAW sensor probe, automatically activating the cooling device for rapid lowering of regional temperature. The cooling device and implantable SAW-sensor will be integrated with a telemetry controlling system with signal processing, seizure detection, decision-making, and triggering functions. The telemetry system is under development.
Bounds for Codes in the Grassmann Manifold (2006)

Upper bounds are derived for codes in the Grass-mann manifold with given minimum chordal distance. They stem from upper bounds for codes in the product of unit spheres and projective spaces. The new bounds are asymptotically better than the previously known ones.
Comparative studies on B cell reactivities in two X-linked immunodeficient mice to the B cell-stimulating factors. (1986)

Responsiveness of B cells from X-linked immunodeficient CBA/N and DBA/2Ha mice to the B cell growth factor-1 (BCGF-I or BSF-1) and B cell differentiation factors (B151-TRF1 and B151-TRF2) was comparatively studied. B cells from CBA/N mice did not respond to BSF-1 in the presence of soluble anti-mu antibody. However, the BSF-1-response of CBA/N B cells was detected when activated by the anti-mu antibody-coupled Sepharose-beads. In the B151-TRF1 assay, antigen-unprimed B cells from CBA/N mice failed to respond to B151-TRF1, whereas antigen-primed B cells became responsive to B151-TRF1. In the B151-TRF2 assay, CBA/N B cells were non-responder to B151-TRF2. In these assays, however, unprimed CBA/N B cells were able to absorb both B151-TRF1- and B151-TRF2-activities to the same extent as the non-defective strain B cells. These results indicate that B cell defect in CBA/N mice may be reflected by some abnormality in signal transmission at encounter to the B cell-stimulating factors but not by inability to bind these factors. These low responder properties of CBA/N B cells were all inherited in an X-linked recessive manner. In contrast, B cells from DBA/2Ha mice well responded to BSF-1 and B151-TRF2, whereas both antigen-unprimed and -primed DBA/2Ha B cells failed to respond to B151-TRF1. This selective B151-TRF1-unresponsiveness of DBA/2Ha B cells was also controlled by an X-linked recessive inheritance. Moreover, in contrast to CBA/N mice, selective unresponsiveness of B cells to B151-TRF1 in DBA/2Ha mice was reflected by the absence of B151-TRF1-receptor expression, as demonstrated by absorption experiment. The B cell populations found in these two distinct X-linked immunodeficient mice may provide an useful experimental model for analyzing B cell activation process mediated by various B cell stimulation factors.
Phase-shifted 1.3-&#x00B5;m dual-mode laser diode: Toward single chip terahertz emitter (2012)

We have developed the λ/4 phase-shifted 1.3-μm dual mode laser as an optical beat source of continuous-wave (CW) terahertz (THz) generation. The mode beat frequency is continuously tuned from 230 to 1485 GHz via integrated micro-heaters. The CW THz system is also demonstrated with low-temperature-grown InGaAs photomixers.
Elevated levels of intracellular cAMP sensitize resting B lymphocytes to immune complex‐induced unresponsiveness (1991)

The ability of immune complexes (IC) to regulate B lymphocyte differentiation was investigated. Using an in vitro model, we previously demonstrated that macrophages (M phi) or lymphoid dendritic cells pulsed with IC differentially regulated B cell function, inducing unresponsiveness or stimulation, respectively. The capacity of M phi to induce unresponsiveness was dependent upon two signals, an antigen-specific one supplied by the IC and M phi-secreted prostaglandin (PG)E2. Total inhibition of antibody production was never achieved as a small percentage of B lymphocytes were resistant to IC-induced unresponsiveness. In this study, utilizing an accessory cell-free system, we demonstrate that splenic B cell fractions separated on Percoll density gradients are heterogeneous in their sensitivity to IC-mediated unresponsiveness. Small resting B lymphocytes are exquisitely sensitive to IC-mediated negative signaling and exhibit virtual total ablation of antibody responses. Conversely, large activated B cells are more refractory to this inhibitory pathway. PGE2 and other agents which elevate cAMP potentiate IC-induced unresponsiveness in resting, but not activated B lymphocytes. In addition treatment of resting B cells with PGF2 alpha, which did not elevate cAMP, failed to sensitize these cells to IC-mediated negative signaling. Unresponsiveness induced by IC is selective for specific aspects of B lymphocyte activation, since B cell differentiation but not proliferation is affected. Furthermore, pre-treatment of resting B lymphocytes with interleukin 4 prevents the IC-induced ablation of IgM antibody responses. Overall, our results indicate that the binding of IC by resting B lymphocytes provides a potent mechanism for inhibiting differentiation without affecting proliferation. These observations suggest that in vivo, IC play an important role in regulating the memory B lymphocyte pathway.
Coupling-induced oscillations in overdamped bistable dynamic systems (2005)

Recently, we have shown the emergence of oscillations in overdamped undriven nonlinear dynamic systems subject to carefully crafted coupling schemes and operating conditions. Here, we summarize these results for a system of N = 3 coupled ferromagnetic cores, the underpinning of a "coupled-core fluxgate magnetometer"(CCFM); the oscillatory behaviour is triggered when the coupling constant exceeds a threshold value (bifurcation point), and the oscillation frequency exhibits a characteristic scaling behaviour with the "separation" of the coupling constant from its threshold value, as well as with an external "target" dc magnetic flux signal. We also present the first (numerical) results on the effects of a (gaussian, exponentially correlated) noise floor on the spectral properties of the system response, and extend our investigations to the large N case, wherein the noise is seen to mediate interesting spatio-temporal cooperative behavior.
Correction. Organic Disulfide and Related Substances. 36. Some Oxodisulfide Cleavage Reactions to Form Disulfides and Trisulfides. (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCorrection. Organic Disulfide and Related Substances. 36. Some Oxodisulfide Cleavage Reactions to Form Disulfides and Trisulfides.Pramod Srivastava and Lamar FieldCite this: J. Org. Chem. 1974, 39, 24, 3617Publication Date (Print):November 1, 1974Publication History Published online21 October 2003Published inissue 1 November 1974https://pubs.acs.org/doi/10.1021/jo00938a602https://doi.org/10.1021/jo00938a602research-articleACS PublicationsRequest reuse permissionsArticle Views21Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
New inhibitors of human renin that contain novel Leu-Val replacements. Examination of the P1 site (1988)

Stereoselective syntheses of several nonpeptide sulfidoethanol fragments that function as Leu10-Val11 (P1-P1') scissile bond replacements in human angiotensinogen are presented. These fragments are prepared from a variety of amino acids with formal P1 side chains varying in size and lipophilicity by converting them to their corresponding N-protected aminoalkyl epoxide 5 followed by ring opening with isopropyl mercaptan. The coupling of these fragments to either Boc-Phe-Ala-OH or Boc-Phe-His-OH produces inhibitors of human renin, 6 and 7, respectively, which are compared to a series of dipeptide-aldehyde inhibitors, 4, by molecular modeling and biochemical methods. Qualitatively, histidine-containing (P2) inhibitors 7 possess greater inhibitory potency than their corresponding alanine (P2) analogues 6, which are more potent than the corresponding aldehydic inhibitors from series 4. Within a given series, inhibitors with the cyclohexylmethyl P1 side chain are more potent than the benzyl analogues, which in turn are more potent than cyclohexyl or isobutyl derivatives. Inhibitors with parger P1 side chains (e.g. adamantylmethyl and benzhydryl) are much less active. The inhibitory potency of these compounds against human renin is discussed in terms of specific interactions with the enzyme.
Inhibition of the Alpha/Beta Interferon Response by Mouse Hepatitis Virus at Multiple Levels (2007)

Mouse hepatitis virus (MHV) was used as a model to study the interaction of coronaviruses with the alpha/beta interferon (IFN-alpha/beta) response. While MHV strain A59 appeared to induce IFN-beta gene transcription and low levels of nuclear translocation of the IFN-beta transcription factor interferon regulatory factor 3 (IRF-3), MHV did not induce IFN-beta protein production during the course of infection in L2 mouse fibroblast cells. In addition, MHV was able to significantly decrease the level of IFN-beta protein induced by both Newcastle disease virus (NDV) and Sendai virus infections, without targeting it for proteasomal degradation and without altering the nuclear translocation of IRF-3 or IFN-beta mRNA production or stability. These results indicate that MHV infection causes an inhibition of IFN-beta production at a posttranscriptional level, without altering RNA or protein stability. In contrast, MHV induced IFN-beta mRNA and protein production in the brains of infected animals, suggesting that the inhibitory mechanisms observed in vitro are not enough to prevent IFN-alpha/beta production in vivo. Furthermore, MHV replication is highly resistant to IFN-alpha/beta action, as indicated by unimpaired MHV replication in L2 cells pretreated with IFN-beta. However, when L2 cells were coinfected with MHV and NDV in the presence of IFN-beta, NDV, but not MHV, replication was inhibited. Thus, rather than disarming the antiviral activity induced by IFN-beta pretreatment completely, MHV may be inherently resistant to some aspects of the antiviral state induced by IFN-beta. These findings show that MHV employs unique strategies to circumvent the IFN-alpha/beta response at multiple steps.
Comparing the photophysics of the two forms of the Orange Carotenoid Protein using 2D electronic spectroscopy (2013)

Broadband two-dimensional electronic spectroscopy is applied to investigate the photophysics of the photoactive orange carotenoid protein, which is involved in nonphotochemical quenching in cyanobacteria. Differences in dynamics between the light and dark forms arise from the different structure of the carotenoid in the protein pocket, with consequences for the biological role of the two forms.
Characterization of Mesophilic Bacteria Degrading Crude Oil from Different Sites of Aramco, Saudi Arabia (2017)

The present study was designed to isolate petroleum hydrocarbon degrading bacterial strains from crude oil contaminated sites near the ARAMCO (Jazan, Saudi Arabia). The main aim was to identify a novel microbial comminutes that possess high degradation potential under variant environmental conditions. Total 43 crude oil degrading bacterial consortiums were isolated and six strains were selected based on high growth rate and hydrocarbon degradation ability. The results of 16S rRNA gene sequences analysis showed that these isolated strains were belonged to genus Pseudomonas, Nitratireductor, Bacillus, Staphylococcus and Erwinia. All isolates bacterial strains showed high degradation potential, however, strain 2-IV (Pseudomonas stutzeri) was the most effective for all parameters. The strain 2-IV showed high degradation rate (77%), emulsifying activity (54.5%), and hydrophobicity (65.5%). Moreover, the production of bio-surfactants and great decrease in surface tension (30.5 mN m−1) was also observed for strain 2-IV compared to the other isolates. On the basis of current research it was concluded that these bacterial strain 2-II and 2-IV can be used for cleaning the environment, respectively. However, further study is needed for identification of fungi and actinomycetes that can act on long-chain hydrocarbons in the studied area.
Effect of radiation on cell proliferation and tumor hypoxia in HPV-positive head and neck cancer in vivo models. (2014)

The radiosensitivity previously observed in vitro could be applied in vivo in respect to a radiation-induced decrease in proliferating cells. A decreasing hypoxic fraction following irradiation in the HPV-positive tumors could explain the lack of benefit from hypoxic modifiers observed in patients.
ChemInform Abstract: Gas Phase Photochemical Synthesis of II/VI Metal Sulfide Films and in situ Luminescence Spectroscopic Identification of Photofragments. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Cylinder-assisted Maker-fringe technique (2003)

A novel cylinder-assisted Maker-fringe technique to measure second-order optical nonlinearity profiles is introduced. Compared to existing methods, this technique improves the measurement ease, speed, and accuracy, and it allowed measuring fringes up to a record incidence angle of ∼89°, which is particularly important for the accurate determination of the profile of thin nonlinear layers.
A Mineralized Collagen-Polycaprolactone Composite Promotes Healing of a Porcine Mandibular Defect (2017)

A tissue engineering approach to address craniofacial defects requires a biomaterial that balances macro-scale mechanical stiffness and strength with the micron-scale features that promote cell expansion and tissue biosynthesis. Such criteria are often in opposition, leading to suboptimal mechanical competence or bioactivity. We report the use of a multiscale composite biomaterial that integrates a polycaprolactone (PCL) reinforcement structure with a mineralized collagen-glycosaminoglycan scaffold to circumvent conventional tradeoffs between mechanics and bioactivity. The composite promotes activation of the canonical bone morphogenetic protein 2 (BMP-2) pathway and subsequent mineralization of adipose-derived stem cells in the absence of supplemental BMP-2 or osteogenic media. We subsequently examined new bone infill in the acellular composite, scaffold alone, or PCL support in 10 mm dia. ramus mandibular defects in Yorkshire pigs. We report an analytical approach to quantify radial, angular, and depth bone infill from micro-computed tomography data. The collagen-PCL composite showed improved overall infill, and significantly increased radial and angular bone infill versus the PCL cage alone. Bone infill was further enhanced in the composite for defects that penetrated the medullary cavity, suggesting recruitment of marrow-derived cells. These results indicate a multiscale mineralized collagen-PCL composite offers strategic advantages for regenerative repair of craniofacial bone defects.