gebhart/patrepeval huggingface dataset:
Relative influence of peak strain delay and peak strain amplitude of non-scarred myocardium in response to cardiac resynchronization therapy: insights from segmental 4D strain analysis (2016)

Background The burden and location of replacement fibrosis by Late Gadolinium Enhancement (LGE) MRI is a recognized predictor of non-response in patients undergoing cardiac resynchronization therapy (CRT). However, the capacity of the non-scarred tissue to respond favorably is felt to be dependent upon incremental factors. In this study we explored the utility of 4D strain analysis of non-scarred myocardial tissue to predict response to CRT.
On computation rates for arithmetic sum (2016)

For zero-error function computation over directed acyclic networks, existing upper and lower bounds on the computation capacity are known to be loose. In this work we consider the problem of computing the arithmetic sum over a specific directed acyclic network that is not a tree. We assume the sources to be i.i.d. Bernoulli with parameter 1/2. Even in this simple setting, we demonstrate that upper bounding the computation rate is quite nontrivial. In particular, it requires us to consider variable length network codes and relate the upper bound to equivalently lower bounding the entropy of descriptions observed by the terminal conditioned on the function value. This lower bound is obtained by further lower bounding the entropy of a so-called clumpy distribution. We also demonstrate an achievable scheme that uses variable length network codes and in-network compression.
A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control (2020)

Hepatic innate immune control of viral infections has largely been attributed to Kupffer cells, the liver macrophages. However, also hepatocytes, the parenchymal cells of the liver, possess potent immunological functions in addition to their known metabolic functions. Owing to their abundance in the liver and known functions, we aimed to investigate the direct anti-viral mechanisms employed by hepatocytes.
S-band gain-clamped grating-based erbium-doped fiber amplifier by forward optical feedback technique (2006)

An S-band gain-clamped erbium-doped fiber amplifier module, employing a fiber Bragg grating to serve as a reflected element for lasing a saturated tone injected into the module by forward optical feedback method, is proposed and investigated experimentally. Moreover, the performance and behavior of the gain and noise figure in the proposed gain-clamped S-band fiber amplifier have also been discussed in the effectively wavelength range of 1478 to 1520 nm.
Synthesis, structures and photoluminescence properties of mixed ligand divalent metal–organic frameworks (2017)

Crystal engineering is an effective route for synthesis of mixed ligand metal–organic frameworks with attractive topologies and versatile potential applications.
Human–Computer Collaboration for Visual Analytics: an Agent‐based Framework (2023)

Abstract The visual analytics community has long aimed to understand users better and assist them in their analytic endeavors. As a result, numerous conceptual models of visual analytics aim to formalize common workflows, techniques, and goals leveraged by analysts. While many of the existing approaches are rich in detail, they each are specific to a particular aspect of the visual analytic process. Furthermore, with an ever‐expanding array of novel artificial intelligence techniques and advances in visual analytic settings, existing conceptual models may not provide enough expressivity to bridge the two fields. In this work, we propose an agent‐based conceptual model for the visual analytic process by drawing parallels from the artificial intelligence literature. We present three examples from the visual analytics literature as case studies and examine them in detail using our framework. Our simple yet robust framework unifies the visual analytic pipeline to enable researchers and practitioners to reason about scenarios that are becoming increasingly prominent in the field, namely mixed‐initiative, guided, and collaborative analysis. Furthermore, it will allow us to characterize analysts, visual analytic settings, and guidance from the lenses of human agents, environments, and artificial agents, respectively.
Supplementary Figure Legends 1-5 from Regulation of the Embryonic Morphogen Nodal by Notch4 Facilitates Manifestation of the Aggressive Melanoma Phenotype (2023)

Supplementary Figure Legends 1-5 from Regulation of the Embryonic Morphogen Nodal by Notch4 Facilitates Manifestation of the Aggressive Melanoma Phenotype
Macrocrystals of Colloidal Quantum Dots in Anthracene: Exciton Transfer and Polarized Emission (2015)

In this work, centimeter-scale macrocrystals of nonpolar colloidal quantum dots (QDs) incorporated into anthracene were grown for the first time. The exciton transfer from the anthracene host to acceptor QDs was systematically investigated, and anisotropic emission from the isotropic QDs in the anthracene macrocrystals was discovered. Results showed a decreasing photoluminescence lifetime of the donor anthracene, indicating a strengthening energy transfer with increasing QD concentration in the macrocrystals. With the anisotropy study, QDs inside the anthracene host acquired a polarization ratio of ~1.5 at 0° collection angle, and this increases to ~2.5 at the collection angle of 60°. A proof-of-concept application of these excitonic macrocrystals as tunable color converters on light-emitting diodes was also demonstrated.
Formation mechanism of the O-induced added-row reconstruction on Ag(110): A low-temperature STM study (1998)

The formation of the O-induced added-row reconstruction on Ag(110) was studied by scanning tunneling microscopy at 190 K. At this temperature critical surface processes are slow enough to be followed on the atomic scale. Ag atoms, which are required for the formation of the reconstruction, detach from steps in a row-wise fashion, starting from kink sites. The growth rate of the added rows is constant and controlled by the detachment rate of Ag atoms from the steps. The data provide evidence for a reconstruction mechanism in which the release of the metal atoms from the steps and the formation of lateral oxygen metal bonds are independent processes.
A simple flow‐injection method for thedetermination of blood glucose using aTechnicon immobilized enzyme coil (1989)

The applicability of a single-channel flow-injection system with immobilized enzyme coil (Technicon) and UV detection to the determination of glucose is described. The method was used for a pure glucose solution and for serum. The detection limit was 0.10 mM, the rate of determination was 20-40 per hour and the precision was satisfactory. The system is very simple and practical when many analysis are to be determined periodically.
Genome Sequence of the Mucoromycotina Fungus Umbelopsis isabellina , an Effective Producer of Lipids (2014)

Umbelopsis isabellina is a fungus in the subdivision Mucoromycotina, many members of which have been shown to be oleaginous and have become important organisms for producing oil because of their high level of intracellular lipid accumulation from various feedstocks. The genome sequence of U. isabellina NBRC 7884 was determined and annotated, and this information might provide insights into the oleaginous properties of this fungus.
Elimination of the light soaking effect and performance enhancement in perovskite solar cells using a fullerene derivative (2016)

The higher dielectric constant and electron donating properties of PTEG-1 electron extraction layer synergistically helps to eliminate the light soaking effect and enhance device performance.
Comparison of Clinical and Dynamic Knee Function in Patients with Anterior Cruciate Ligament Deficiency (2003)

Absolute knee laxity difference did not correlate with dynamic knee function as assessed by gait analysis and should not be used as a sole predictor for the outcome of treatment. Patients with greater than normal strength in the anterior cruciate ligament-deficient limb performed low- and high-stress activities in a more normal fashion than those with normal or less-than-normal strength.
Respiration‐based sorting of dynamic MRI to derive representative 4D‐MRI for radiotherapy planning (2013)

They have presented a novel methodology employing dMRI to derive representative 4D-MRI. This set of techniques are practical in that (1) they employ MRI sequences that are standard across commercial vendors; (2) the 2D imaging planes can be oriented onto an arbitrary axis (e.g., sagittal, coronal, axial[ellipsis (horizontal)]); (3) the image processing techniques are relatively simple. Systematically applying this and similar dMRI-based techniques in patients is a crucial next step to demonstrate efficacy beyond CT-only based practice.
High-Throughput Large Volume SEM Workflow using Sparse Scanning and In-painting Algorithms Inspired by Compressive Sensing (2017)

We are presenting a new extension to our Cell and Tissue/Neurobiology large volume imaging workflow, with the goal of increasing acquisition speed by more than five times. Instead of scanning dense square-grid frames, in the conventional way, our approach is here to explore the use of sparse scanning and inpainting techniques inspired by Compressive Sensing (CS) Sparse samples are obtained by pseudo-random scan patterns, and reconstruction algorithms are used to recover the dense volume data. The goal is to recover 3D datasets with minimum loss of information. Techniques inspired by CS gained wide attention over the last decade and are now being used in various applications where sensor bandwidth is a limiting factor. They have been recently explored for SEM and STEM applications [2][3]. In the context of nano-scale cell biology volume acquisition, we expect these techniques to ultimately increase the imaging throughput by nearly an order of magnitude. We will discuss additional advantages of this approach, such as the low-dose imaging of sensitive specimens, and the good compatibility with backscatter electron imaging. A key enabler of any sparse scan application to EM is the accurate control of scan locations. It has been shown in We have developed advanced minimum-path scanning strategies to address this issue. The scanning technique is illustrated in Fig. The right two images of Fig. In future work we will compare pseudo-random sparse sampling, in combination with a reconstruction algorithm based on CS-inspired in-painting, to conventional grid sampling of the same effective dose, in combination with a de-noising algorithm, also based on CS. CS machine learning algorithms build patch-dictionaries, which are used as the building blocks for data representation During live acquisition runs, such dictionaries can be used to in-paint with high fidelity, the sparsely sampled datasets (Figure We are implementing the new sparse scanning modules on SEM platforms, which also employ the Multi Energy Deconvolution SEM (MED-SEM) technology and Serial Block Face (SBF) imaging By incorporating CS, we will have an instrument allowing for both high-resolution isotropic imaging, and the fast acquisition of very large datasets (Figure
Microfluidic in-line dynamic light scattering with a commercial fibre optic system (2023)

We report the coupling of dynamic light scattering (DLS) in microfluidics, using a contact-free fibre-optic system, enabling the under-flow characterisation of a range of solutions, dispersions, and structured fluids. The system is evaluated and validated with model systems, specifically micellar and (dilute) polymer solutions, and colloidal dispersions of different radii (∼1-100 nm). A systematic method of flow-DLS analysis is examined as a function of flow velocity (0-16 cm s<sup>-1</sup>), and considerations of the relative contribution of 'transit' and 'Brownian' terms enable the identification of regions where (i) a quiescent approximation suffices, (ii) the flow-DLS framework holds, as well as (iii) where deviations are found, until eventually (iv) the convection dominates. We investigate practically relevant, robust setups, namely that of a capillary connected to microdevice, as well as direct measurement on a glass microdevice, examining the role of capillary dimensions and challenges of optical alignment. We conclude with a demonstration of a continuous flow measurement of a binary surfactant/salt solution, whose micellar dimensions vary with composition, characterised with hundreds of data points (every ∼5 s) and adequate statistics, within a few minutes.
Effects of Nonlinear Damping Washers on the Automatic Ball Balancer for Optical Disk Drives (2005)

This study is devoted to explore the effect of nonlinear dynamics of damping washers on the dynamic performance of automatic ball balancer (ABB) system installed in optical disc drives. The ABB is generally used on rotational system to reduce vibration. Researches have been conducted to study the performance of the ABB by investigating the nonlinear dynamics of the system; however, the model adopted often consider the damping washer in a typical ABB suspension system as a linear one, which does not reflect the fact that the practical washers are inevitably exhibit nontrivial nonlinear dynamics at some range of operation, deviating the ABB performance away from the expecteds. In this study, a complete dynamic model of the ABB including a detailed nonlinear model of the damping washers based on experimental data for practical wahers is established. The method of multiple scales is then applied to formulate a scaled model to find all possible steady-state ball positions and analyze stabilities. It is found that with reasonable level of nonlinearity, the balancing balls of the ABB are still reside at the desired positions at steady state, rendering expected vibration reduction; however, jump phenomena also occurs as the spindle operated through natural frequency of the suspension, causing unwanted system vibrations. Numerical simulations and experiments are conducted to verify the theoretical findings. The obtained results are used to predict the level of residual vibration, with which the guidelines on choices of the nonlinear damping washers are distilled to achieve desired performance.
Faculty Opinions recommendation of Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice. (2005)

Read the full review for this Faculty Opinions recommended article: Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice.
Data from First-in-Human Clinical Trial of Oral ONC201 in Patients with Refractory Solid Tumors (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; ONC201 is a small-molecule selective antagonist of the G protein–coupled receptor DRD2 that is the founding member of the imipridone class of compounds. A first-in-human phase I study of ONC201 was conducted to determine its recommended phase II dose (RP2D).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; This open-label study treated 10 patients during dose escalation with histologically confirmed advanced solid tumors. Patients received ONC201 orally once every 3 weeks, defined as one cycle, at doses from 125 to 625 mg using an accelerated titration design. An additional 18 patients were treated at the RP2D in an expansion phase to collect additional safety, pharmacokinetic, and pharmacodynamic information.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; No grade &gt;1 drug-related adverse events occurred, and the RP2D was defined as 625 mg. Pharmacokinetic analysis revealed a &lt;i&gt;C&lt;/i&gt;&lt;sub&gt;max&lt;/sub&gt; of 1.5 to 7.5 μg/mL (∼3.9–19.4 μmol/L), mean half-life of 11.3 hours, and mean AUC of 37.7 h·μg/L. Pharmacodynamic assays demonstrated induction of caspase-cleaved keratin 18 and prolactin as serum biomarkers of apoptosis and DRD2 antagonism, respectively. No objective responses by RECIST were achieved; however, radiographic regression of several individual metastatic lesions was observed along with prolonged stable disease (&gt;9 cycles) in prostate and endometrial cancer patients.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; ONC201 is a selective DRD2 antagonist that is well tolerated, achieves micromolar plasma concentrations, and is biologically active in advanced cancer patients when orally administered at 625 mg every 3 weeks. &lt;i&gt;Clin Cancer Res; 23(15); 4163–9. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Simultaneously Structured Models With Application to Sparse and Low-Rank Matrices (2015)

Recovering structured models (e.g., sparse or group-sparse vectors, low-rank matrices) given a few linear observations have been well-studied recently. In various applications in signal processing and machine learning, the model of interest is structured in several ways, for example, a matrix that is simultaneously sparse and low rank. Often norms that promote the individual structures are known, and allow for recovery using an order-wise optimal number of measurements (e.g., 11 norm for sparsity, nuclear norm for matrix rank). Hence, it is reasonable to minimize a combination of such norms. We show that, surprisingly, using multiobjective optimization with these norms can do no better, orderwise, than exploiting only one of the structures, thus revealing a fundamental limitation in sample complexity. This result suggests that to fully exploit the multiple structures, we need an entirely new convex relaxation. Further, specializing our results to the case of sparse and low-rank matrices, we show that a nonconvex formulation recovers the model from very few measurements (on the order of the degrees of freedom), whereas the convex problem combining the 11 and nuclear norms requires many more measurements, illustrating a gap between the performance of the convex and nonconvex recovery problems. Our framework applies to arbitrary structure-inducing norms as well as to a wide range of measurement ensembles. This allows us to give sample complexity bounds for problems such as sparse phase retrieval and low-rank tensor completion.
Hybrid organic-inorganic films fabricated using atomic and molecular layer deposition (2013)

Atomic layer deposition (ALD) and molecular layer deposition (MLD) are based on sequential, self-limiting surface reactions that produce atomic layer controlled and conformal thin film growth. ALD can deposit inorganic films and MLD can deposit films containing organics. ALD and MLD can be used together to fabricate a wide range of flexible hybrid organic-inorganic films. The tunable mechanical properties of alucone alloys grown using Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> ALD and alucone MLD may be useful as flexible barrier films. The tunable electrical conductivity of zincone alloys grown using ZnO ALD and zincone MLD may be useful as flexible transparent conducting films. These hybrid organic-inorganic films could have many applications for flexible sensors and actuators.
BH3-only Protein Noxa Is a Mediator of Hypoxic Cell Death Induced by Hypoxia-inducible Factor 1α (2003)

Hypoxia is a common cause of cell death and is implicated in many disease processes including stroke and chronic degenerative disorders. In response to hypoxia, cells express a variety of genes, which allow adaptation to altered metabolic demands, decreased oxygen demands, and the removal of irreversibly damaged cells. Using polymerase chain reaction-based suppression subtractive hybridization to find genes that are differentially expressed in hypoxia, we identified the BH3-only Bcl-2 family protein Noxa. Noxa is a candidate molecule mediating p53-induced apoptosis. We show that Noxa promoter responds directly to hypoxia via hypoxia-inducible factor (HIF)-1alpha. Suppression of Noxa expression by antisense oligonucleotides rescued cells from hypoxia-induced cell death and decreased infarction volumes in an animal model of ischemia. Further, we show that reactive oxygen species and resultant cytochrome c release participate in Noxa-mediated hypoxic cell death. Altogether, our results show that Noxa is induced by HIF-1alpha and mediates hypoxic cell death.
Ionic liquid-functionalized mesoporous sorbents and their use in the capture of polluting gases (2023)

A composite structure for capturing a gaseous electrophilic species, the composite structure comprising mesoporous refractory sorbent particles on which an ionic liquid is covalently attached, wherein said ionic liquid includes an accessible functional group that is capable of binding to said gaseous electrophilic species. In particular embodiments, the mesoporous sorbent particles are contained within refractory hollow fibers. Also described is a method for capturing a gaseous electrophilic species by use of the above-described composite structure, wherein the gaseous electrophilic species is contacted with the composite structure. In particular embodiments thereof, cooling water is passed through the refractory hollow fibers containing the IL-functionalized sorbent particles in order to facilitate capture of the gaseous electrophilic species, and then steam is passed through the refractory hollow fibers to facilitate release of the gaseous electrophilic species such that the composite structure can be re-used to capture additional gas.
Estimation of time delays in multirate asynchronous DS-CDMA systems (2002)

This article treats the problem of time delay estimation in a multirate asynchronous direct-sequence code-division multiple access (DS-CDMA) system in a near-far scenario. A subspace based algorithm for the time delay estimation problem is proposed. The algorithm is a minor modified version of the MUSIC estimator proposed by Ostman, Parkvall and Ottersten (see Proceedings of the 31st Asilomar Conference on Signals, Systems and Computers, 1997). Through theoretical analysis and simulations it is shown that the subspace approach to time delay estimation in a multirate DS-CDMA system is applicable when the algorithm is applied in a way such that the low-rank structure of the system is conserved.
Cardioselective KATP Channel Blockers Derived from a New Series of m-Anisamidoethylbenzenesulfonylthioureas (2001)

Sulfonylthioureas exhibiting cardioselective blockade of ATP-sensitive potassium channels (K(ATP) channels) were discovered by stepwise structural variations of the antidiabetic sulfonylurea glibenclamide. As screening assays, reversal of rilmakalim-induced shortening of the cardiac action potential in guinea pig papillary muscles was used to probe for activity on cardiac K(ATP) channels as the target, and membrane depolarization in CHO cells stably transfected with hSUR1/hKir6.2 was used to probe for unwanted side effects on pancreatic K(ATP) channels. Changing glibenclamide's para-arrangement of substituents in the central aromatic ring to a meta-pattern associated with size reduction of the substituent at the terminal nitrogen atom of the sulfonylurea moiety was found to achieve cardioselectivity. An additional change from a sulfonylurea moiety to a sulfonylthiourea moiety along with an appropriate substituent in the ortho-position of the central aromatic system was a successful strategy to further improve potency on the cardiac K(ATP) channel. Among this series of sulfonylthioureas HMR1883, 1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3-methylthiourea, and its sodium salt HMR1098 were selected for development and represent a completely new therapeutic approach toward the prevention of life-threatening arrhythmias and sudden cardiac death in patients with coronary heart disease.