gebhart/patrepeval huggingface dataset:
Magnetic Characterization and Computational Modeling of Poly(phenylacetylenes) Bearing Stable Radical Groups (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMagnetic Characterization and Computational Modeling of Poly(phenylacetylenes) Bearing Stable Radical GroupsHiroyuki Nishide, Takashi Kaneko, Masukazu Igarashi, Eishun Tsuchida, Naoki Yoshioka, and Paul M. LahtiCite this: Macromolecules 1994, 27, 11, 3082–3086Publication Date (Print):May 1, 1994Publication History Published online1 May 2002Published inissue 1 May 1994https://pubs.acs.org/doi/10.1021/ma00089a027https://doi.org/10.1021/ma00089a027research-articleACS PublicationsRequest reuse permissionsArticle Views204Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Internal quantum efficiency of highly-efficient InxGa1−xN-based near-ultraviolet light-emitting diodes (2003)

The internal quantum efficiency (IQE) of highly-efficient near-UV light-emitting diodes, which shows an external quantum efficiency of 43% at 406 nm, has been measured by excitation power and temperature-dependent photoluminescence (PL). Assuming peak PL quantum efficiency at 8 K is 100%, peak IQE at 300 K was measured to be as high as 63%. At the injected carrier density, which corresponds to 20 mA current injection, IQE and light extraction efficiency were estimated to be about 54% and 80%, respectively.
Revision anatomic shoulder arthroplasty with posterior capsular plication for correction of posterior instability (2018)

PCP to correct posterior instability during revision anatomic shoulder arthroplasty had an unacceptably high failure rate. In these circumstances, consideration should instead be given to conversion to a reverse shoulder arthroplasty.
Inhibition of acyl‐ACP thioesterase as site of action of the commercial herbicides cumyluron, oxaziclomefone, bromobutide, methyldymron and tebutam (2022)

Based on presented data, we corroborate cinmethylin and methiozolin as potent FAT inhibitors and identify FAT as the SoA of the herbicides cumyluron, oxaziclomefone, bromobutide, methyldymron and tebutam. © 2022 Society of Chemical Industry.
Schottky-Barrier Metal–Oxide–Semiconductor Field-Effect Transistors as Resonant Tunneling Devices (2010)

The current–voltage characteristics of double-gated Schottky-barrier metal–oxide–semiconductor field-effect transistor (MOSFET) 10 nm in length and with body thickness of 3 nm is numerically studied, illustrating a similarity between the rectangular quantum well cavity in conventional resonant tunneling diodes and the parabolic-like cavity created by a pair of Schottky junctions in scaled Schottky-barrier MOSFETs. Assuming ballistic transport for electrons within effective mass approximation, the appearance of negative differential resistance due to the resonant tunneling effect between the Schottky junctions of 0.75 eV height is confirmed by non-equilibrium Green's function simulation. In such scaled Schottky-barrier MOSFETs, the tunneling electrons by themselves determine the shape of resonant potential, through the charge terms in electrostatic field equations. Using both the Poisson equation and the Laplace equation, we highlight the importance of the self-consistency for realizing successful resonant tunneling operation in scaled Schottky-barrier MOSFETs.
Ultra-Fast All-Optical Modulator Using Nano-Waveguide Embedded in High Pressure Buffer Gas (2015)

We propose implementation of an ultra-fast, low power all-optical modulator at telecommunication wavelength via interaction of evanescent light field around a silicon nitride nano waveguide with Rubidium vapor under high pressure buffer gas.
Evidence of color coherence effects in W+jets events from p collisions at =1.8 TeV (1999)

We report the results of a study of color coherence effects in pp collisions based on data collected by the DØ detector during the 1994–1995 run of the Fermilab Tevatron Collider, at a center of mass energy s=1.8 TeV. Initial-to-final state color interference effects are observed by examining particle distribution patterns in events with a W boson and at least one jet. The data are compared to Monte Carlo simulations with different color coherence implementations and to an analytic modified-leading-logarithm perturbative calculation based on the local parton-hadron duality hypothesis.
Fluorophotometric study of intravenous carbonic anhydrase inhibitors in rabbits. (1987)

The ability of fluorophotometry to measure the time course of changes in aqueous humor flow in rabbits was evaluated by measuring the effect of intravenous carbonic anhydrase inhibitors on aqueous humor flow determinations. The abrupt changes in aqueous humor flow which were found by fluorophotometry agreed well with the expected changes in aqueous humor flow calculated from the time course of the intraocular pressure. Therefore, it was concluded that fluorophotometry could measure the time course of changes in aqueous humor flow in rabbits. Furthermore, it was suggested that the initial abrupt changes in aqueous humor flow after the administration of a carbonic anhydrase inhibitor were induced by the base content of the drug, followed by a more gradual decrease in aqueous humor flow caused by the direct effect of the drug on aqueous humor formation.
The ice-nucleating activity of African mineral dust in the Caribbean boundary layer (2022)

Abstract. African mineral dust is transported many thousands of kilometres from its source regions and, because of its ability to nucleate ice, it plays a major role in cloud glaciation around the globe. The ice-nucleating activity of desert dust is influenced by its mineralogy, which varies substantially between source regions and across particle sizes. However, in models it is often assumed that the activity (expressed as active sites per unit surface area as a function of temperature) of atmospheric mineral dust is the same everywhere on the globe. Here, we find that the ice-nucleating activity of African desert dust sampled in the summertime marine boundary layer of Barbados (July and August, 2017) is substantially lower than parameterizations based on soil from specific locations in the Saharan desert or dust sedimented from dust storms. We conclude that the activity of dust in Barbados’ boundary layer is primarily defined by the low K-feldspar content of the dust, which is around 1 %. We propose that the dust we sampled in the Caribbean was from a region in West Africa (in and around the Sahel in Mauritania and Mali), which has a much lower feldspar content than other African sources across the Sahara and Sahel.
SUPPRESSION OF PRIMARY TUMOR GROWTH AND THE PROGRESSION TO METASTASIS WITH p53 ADENOVIRUS IN HUMAN PROSTATE CANCER (2000)

Numerous advances have been made in gene therapy approaches for the treatment of solid tumors, including prostate cancer. While treatment of the primary tumor has been well investigated, little information is available regarding gene therapy techniques which might impact on the progression to metastatic disease. We investigate the ability of p53 adenovirus to suppress not only primary tumor growth, but also the progression to metastatic disease. Mutation of the p53 tumor suppressor gene has been associated with the progression of prostate cancer. In this study, we utilized a metastatic model for human prostate cancer to determine if introduction of the wild-type p53 gene using an adenoviral vector (rAd-p53) impacted on primary tumor growth as well as the progression to metastatic disease.For our studies, we used the human prostate cancer cell line PC-3, which has a homozygous loss of p53 expression. Expression of exogenous p53 as well as p21 induction at various time points after infection with rAd-p53 was determined in vitro. In vivo studies were performed in nude mice following orthotopic (intraprostatic) injection of PC-3 cells. Primary tumor growth as well as the progression to metastatic disease was assessed following rAd-p53 treatment.In vitro studies demonstrated high levels of p53 gene expression as well as the induction of p21 gene expression. Infection of PC-3 cells with rAd-p53 resulted in marked growth inhibition, as well as wide-spread fragmentation of nuclei and secretion of nuclear matrix proteins into the culture medium consistent with the process of apoptosis. In vivo studies demonstrated that a single injection of rAd-p53 into an established orthotopic prostate tumor resulted not only in primary tumor growth suppression (treated = 97.5 +/- 25.3 mm.3 versus control = 393.4 +/- 67.2 mm.3; p = 0.0002) but also reduced the frequency of progression to metastatic disease (treated = 8 of 19 versus control = 18 of 19; p = 0.001).These experiments demonstrate that a single injection of rAd-p53 into an established orthotopic prostate tumor results not only in suppression of primary tumor growth, but also in a reduction of the frequency of progression to metastatic disease. These results suggest that a rAd-p53 gene therapy strategy may be useful in the treatment of human prostate cancer.
The use of EUV lithography to produce demonstration devices (2008)

In this paper, we describe the integration of EUV lithography into a standard semiconductor manufacturing flow to produce demonstration devices. 45 nm logic test chips with functional transistors were fabricated using EUV lithography to pattern the first interconnect level (metal 1). This device fabrication exercise required the development of rule-based 'OPC' to correct for flare and mask shadowing effects. These corrections were applied to the fabrication of a full-field mask. The resulting mask and the 0.25-NA fullfield EUV scanner were found to provide more than adequate performance for this 45 nm logic node demonstration. The CD uniformity across the field and through a lot of wafers was 6.6% (3&sigma;) and the measured overlay on the test-chip (product) wafers was well below 20 nm (mean + 3&sigma;). A resist process was developed and performed well at a sensitivity of 3.8 mJ/cm<sup>2</sup>, providing ample process latitude and etch selectivity for pattern transfer. The etch recipes provided good CD control, profiles and end-point discrimination, allowing for good electrical connection to the underlying levels, as evidenced by electrical test results. Many transistors connected with Cu-metal lines defined using EUV lithography were tested electrically and found to have characteristics very similar to 45 nm node transistors fabricated using more traditional methods.
New Approach for Generating and (De)Multiplexing OAM Modes in a Fiber Coupler Consisting of a Central Ring and Four External Cores (2011)

We propose a fiber coupler to generate up to ten orbital angular momentum modes, which can be generated with 20-dB extinction ratio and mode purity of &gt;99% using a 2-mm-long fiber. The fiber design can be extended to enable all-fiber spatial mode (de)multiplexing.
10705 Analytical Study on Bolt Loosing Detection in Composite Shear Fastener by Smart Bolt (2015)

In the aircraft structure, the weight reduction is severely demanded and recently there exist many fastener joints between metal and composite parts. Therefore, it is important to investigate the mechanical behavior and evaluate the damage of bolt in composite/metal fastener joint. The authors proposed the smart bolt embedded optical fiber sensor as a monitoring instrument of the fastener joint. In the previous study, it was shown that the bolt fall in the multiple-row fastener joint can be detected by using the smart bolt, hi this study, FEM analyses for the multiple-row fastener joint of in-line array specimen were conducted assuming the looseness of a joining bolt. Based on the analytical results, it was shown that the bolt looseness around the smart bolt can be detected.
A 90nm CMOS cryptographic core with improved fault-tolerance in presence of massive defect density (2010)

This paper presents the development methodology, circuit realization and measurement of a cryptographic core intended to operate reliably in the presence of massive defect density. A circuit-level voter based on averaging and thresholding has been implemented, and is measured to offer superior reliability in comparison with standard techniques.
Lymphatic Vessels in Tumor Dissemination versus Immunotherapy (2020)

During the growth of various cancers, primary tumors can escape antitumor immune responses of their host and eventually disseminate into distant organs. Peritumoral lymphatic vessels connect the primary tumor to lymph nodes, facilitating tumor entry into lymph nodes, systemic circulation, and metastasis. Lymph node metastases that occur frequently provide sites of tumor cell spread, whereas tumor antigen transfer into and presentation in tumor-draining lymph nodes induce activation of tumor-specific T-lymphocyte responses that can result in cytolytic targeting of the tumor. Here, we discuss the recently emerged controversial role of the lymphatic vessels in tumor dissemination and cancer immunotherapy.
Multi-platform Affinity Proteomics Identify Proteins Linked to Metastasis and Immune Suppression in Ovarian Cancer Plasma (2019)

A central reason behind the poor clinical outcome of patients with high-grade serous carcinoma (HGSC) of the ovary is the difficulty in reliably detecting early occurrence or recurrence of this malignancy. Biomarkers that provide reliable diagnosis of this disease are therefore urgently needed. Systematic proteomic methods that identify HGSC-associated molecules may provide such biomarkers. We applied the antibody-based proximity extension assay (PEA) platform (Olink) for the identification of proteins that are upregulated in the plasma of OC patients. Using binders targeting 368 different plasma proteins, we compared 20 plasma samples from HGSC patients (OC-plasma) with 20 plasma samples from individuals with non-malignant gynecologic disorders (N-plasma). We identified 176 proteins with significantly higher levels in OC-plasma compared to N-plasma by PEA (<i>p</i> < 0.05 by <i>U-</i>test; Benjamini-Hochberg corrected), which are mainly implicated in immune regulation and metastasis-associated processes, such as matrix remodeling, adhesion, migration and proliferation. A number of these proteins have not been reported in previous studies, such as BCAM, CDH6, DDR1, N2DL-2 (ULBP2), SPINT2, and WISP-1 (CCN4). Of these SPINT2, a protease inhibitor mainly derived from tumor cells within the HGSC microenvironment, showed the highest significance (<i>p</i> < 2 × 10<sup>-7</sup>) similar to the previously described IL-6 and PVRL4 (NECTIN4) proteins. Results were validated by means of the aptamer-based 1.3 k SOMAscan proteomic platform, which revealed a high inter-platform correlation with a median Spearman ρ of 0.62. Likewise, ELISA confirmed the PEA data for 10 out of 12 proteins analyzed, including SPINT2. These findings suggest that in contrast to other entities SPINT2 does not act as a tumor suppressor in HGSC. This is supported by data from the PRECOG and KM-Plotter meta-analysis databases, which point to a tumor-type-specific inverse association of <i>SPINT2</i> gene expression with survival. Our data also demonstrate that both the PEA and SOMAscan affinity proteomics platforms bear considerable potential for the unbiased discovery of novel disease-associated biomarkers.
Peripheral blood CD4+ T lymphocytes from multiple sclerosis patients are characterized by higher PSGL-1 expression and transmigration capacity across a human blood-brain barrier-derived endothelial cell line (2009)

Mechanisms of T lymphocyte trafficking in the brain remain unclear in MS. We hypothesized that MS is associated with increased CD4+ and CD8+ T lymphocyte trafficking across the BBB. To test this hypothesis, we calculated the frequency of PSGL-1+/CD4+ and PSGL-1+CD8+ or LFA-1+/CD4+/CD8+ T cells in the PBMC of 27 patients with a RR-MS (21 untreated and six IFN-beta-treated) and 18 HI. Next, we measured their ex vivo TR across resting and TNF-alpha-activated human BBB-derived hCMEC/D3 endothelial layers under static conditions. The frequency of PSGL-1+CD4+ T lymphocytes was significantly higher in treated or untreated MS patients than HI. Furthermore, resting hCMEC/D3 TR of CD4+ lymphocytes (purified or in PBMC) from treated or untreated MS patients were significantly higher than those of HI and associated with significant enrichments of CD4+PSGL+ or CD4+PSGL-1+CD45RO+ T cells in their transmigrating fractions. The TR of CD4+ and CD8+ from MS patients across TNF-alpha-activated hCMEC/D3 were also significantly higher than that observed in HI. Resting hCMEC/D3 transmigration was blocked significantly by anti-PSGL-1/anti-LFA-1 in all groups, and anti-VLA-4 inhibited transmigration of MS T cells specifically. Purified PSGL-1-negative CD4+ lymphocytes transmigrated resting hCMEC/D3 with <10% of transmigrating cells re-expressing PSGL-1, suggesting PSGL-1-independent transmigration mechanisms. The frequency of PSGL-1 was unchanged in CD8+ cells from MS patients, whereas CD8+LFA-1(high) were reduced significantly in IFN-beta-treated patients specifically. Collectively, MS is associated with an expanding pool of PSGL-1+CD4+ T lymphocytes able to transmigrate the BBB endothelium in vitro and possibly contributing to brain pathology.
Sertoli Cells Loaded with Doxorubicin in Lipid Micelles Reduced Tumor Burden and Dox-Induced Toxicity (2017)

The toxic side effects of doxorubicin (Dox) limit its long-term use as a lung cancer chemotherapeutic. Additionally, drug delivery to the deep lung is challenging. To address these challenges, isolated rat Sertoli cells (SCs) were preloaded with Dox conjugated to lipid micelle nanoparticles (SC-DLMNs) and delivered to mouse lungs. These immunocompetent cells, when injected intravenously, travel to the lung, deliver the payload, and get cleared by the system quickly without causing any adverse reaction. We observed that SC-DLMNs effectively treated Lewis lung carcinoma 1-induced lung tumors in mice and the drug efficacy was comparable to SC-Dox treatment. Mice treated with SC-DLMNs also showed significantly less toxicity compared to those treated with SC-Dox. The encapsulation of Dox in lipid micelle nanoparticles reduced the toxicity of Dox and the SC-based delivery method ensured drug delivery to the deep lung without evoking any immune response. Taken together, these results provide a novel SC-based nanoparticle drug delivery method for improved therapeutic outcome of cardiotoxic antilung cancer drugs.
Polybenzimidazole-Based Polymer Electrolyte Membranes for High-Temperature Fuel Cells: Current Status and Prospects (2020)

Polymer electrolyte membrane fuel cells (PEMFCs) expect a promising future in addressing the major problems associated with production and consumption of renewable energies and meeting the future societal and environmental needs. Design and fabrication of new proton exchange membranes (PEMs) with high proton conductivity and durability is crucial to overcome the drawbacks of the present PEMs. Acid-doped polybenzimidazoles (PBIs) carry high proton conductivity and long-term thermal, chemical, and structural stabilities are recognized as the suited polymeric materials for next-generation PEMs of high-temperature fuel cells in place of Nafion® membranes. This paper aims to review the recent developments in acid-doped PBI-based PEMs for use in PEMFCs. The structures and proton conductivity of a variety of acid-doped PBI-based PEMs are discussed. More recent development in PBI-based electrospun nanofiber PEMs is also considered. The electrochemical performance of PBI-based PEMs in PEMFCs and new trends in the optimization of acid-doped PBIs are explored.
A systematic approach to classify design-time global scheduling techniques (2013)

The scheduling problem is an important partially solved topic related to a wide range of scientific fields. As it applies to design-time mapping on multiprocessing platforms emphasizing on ordering in time and assignment in place, significant improvements can be achieved. To support this improvement, this article presents a complete systematic classification of the existing scheduling techniques solving this problem in a (near-)optimal way. We show that the proposed approach covers any global scheduling technique, including also future ones. In our systematic classification a technique may belong to one primitive class or to a hybrid combination of such classes. In the latter case the technique is efficiently decomposed into more primitive components each one belonging to a specific class. The systematic classification assists in the in-depth understanding of the diverse classes of techniques which is essential for their further improvement. Their main characteristics and structure, their similarities and differences, and the interrelationships of the classes are conceived. In this way, our classification provides guidance for contributing in novel ways to the broad domain of global scheduling techniques.
Crystal Structure and Spectroscopic Studies of a Stable Mixed-Valent State of the Hemerythrin-like Domain of a Bacterial Chemotaxis Protein (2011)

The bacterial chemotaxis protein of Desulfovibrio vulgaris DcrH (DcrH-Hr) functions as an O(2)-sensing protein. This protein has a hemerythrin-like domain that includes a nonheme diiron center analogous to the diiron center of the hemerythrin (Hr) family. Interestingly, the O(2) affinity of DcrH-Hr is 3.3 × 10(6) M(-1), a value 25-fold higher than that of the Pectinaria gouldii Hr. This high affinity arises from the fast association of the O(2) ligand with DcrH-Hr (k(on) = 5.3 × 10(8) M(-1) s(-1)), which is made possible by a hydrophobic tunnel that accelerates the passage of the O(2) ligand to the diiron site. Furthermore, the autoxidation kinetics indicate that the rate of autoxidation of DcrH-Hr is 54-fold higher than that of P. gouldii Hr, indicating that the oxy form of DcrH-Hr is not stable toward autoxidation. More importantly, a mixed-valent state, semimet(R), which was spectroscopically observed in previous Hr studies, was found to be stable for over 1 week and isolable in the case of DcrH-Hr. The high-resolution crystal structures of the semimet(R)- (1.8 Å) and met-DcrH-Hr (1.4 Å) indicate that the semimet(R)- and met-DcrH-Hr species have very similar coordination geometry at the diiron site.