gebhart/patrepeval huggingface dataset:
The stimulation of collagenase production in rabbit articular chondrocytes by interleukin-1 is increased by collagens. (1987)

Osteoarthritis is characterized by a loss of articular cartilage due at least in part to the action of degradative enzymes secreted by chondrocytes. We have investigated the effect of type II collagen from cartilage and interleukin 1 on collagenase production in cultures of rabbit articular chondrocytes. Interleukin 1 alone stimulated the chondrocytes to secrete collagenase but this response was increased as much as fivefold by the addition of rabbit type II collagen. Bovine type II and chick type I collagens were also stimulatory. The native form of the collagens was not required since denatured collagens and purified chick type II alpha chains were effective. The observed effects of collagens and interleukin 1 may contribute to the progressive nature of osteoarthritis.
Characterization of the Mode of Incorporation of Lipophilic Compounds in Solid Dispersions at the Nanoscale Using Fluorescence Resonance Energy Transfer (FRET) (2006)

Abstract Summary: Efficient engineering of solid dispersions stagnates by the current inability to establish the mode of drug distribution on a molecular level at a low drug load. This study describes the application of fluorescence resonance energy transfer (FRET) to characterize the mode of incorporation of dispersed lipophilic molecules in a solid matrix. Two different lipophilic fluorophores (donor and acceptor) were used as model substances and were incorporated in polyvinylpyrrolidone to form solid dispersions using two different production processes: lyophilization and fusion. The efficiency of the resonance energy transfer from donor to acceptor was measured by confocal microscopy. We show that the method can be used to compare the modes of drug incorporation of solid dispersions at the nanoscale. Absorption and emission spectra of Bodipy R6G (donor) and Bodipy 650/665 (acceptor). magnified image Absorption and emission spectra of Bodipy R6G (donor) and Bodipy 650/665 (acceptor).
Enhancing PMD monitoring and compensation for DPSK and DQPSK signals using variable DGD modules (2008)

Facilitated by variable differential-group-delay (DGD) modules, we propose a simple method to extend polarizationmode- dispersion (PMD) monitoring windows three times larger using either degree-of-polarization (DOP) for 40-Gbaud differential-phase-shifted-keying (DPSK) differential-quadrature-phase-shifted-keying (DQPSK) signals. Such approach can be further incorporated into PMD compensators.
Adenoviral Constructs Encoding Phosphorylation-Competent Full-length and Truncated Forms of the Human Retinoblastoma Protein Inhibit Myocyte Proliferation and Neointima Formation (1997)

These analyses revealed that the maintenance of high levels of phosphorylation-competent human Rb, either full-length or truncated forms, in VSMCs is an effective method of modulating the extent of intimal hyperplasia that occurs after balloon-induced vascular injury.
Active Terminal Identification, Channel Estimation, and Signal Detection for Grant-Free NOMA-OTFS in LEO Satellite Internet-of-Things (2022)

This paper investigates the massive connectivity of low Earth orbit (LEO) satellite-based Internet-of-Things (IoT) for seamless global coverage. We propose to integrate the grant-free non-orthogonal multiple access (GF-NOMA) paradigm with the emerging orthogonal time frequency space (OTFS) modulation to accommodate the massive IoT access, and mitigate the long round-trip latency and severe Doppler effect of terrestrial-satellite links (TSLs). On this basis, we put forward a two-stage successive active terminal identification (ATI) and channel estimation (CE) scheme as well as a low-complexity multi-user signal detection (SD) method. Specifically, at the first stage, the proposed training sequence aided OTFS (TS-OTFS) data frame structure facilitates the joint ATI and coarse CE, whereby both the traffic sparsity of terrestrial IoT terminals and the sparse channel impulse response are leveraged for enhanced performance. Moreover, based on the single Doppler shift property for each TSL and sparsity of delay-Doppler domain channel, we develop a parametric approach to further refine the CE performance. Finally, a least square based parallel time domain SD method is developed to detect the OTFS signals with relatively low complexity. Simulation results demonstrate the superiority of the proposed methods over the state-of-the-art solutions in terms of ATI, CE, and SD performance confronted with the long round-trip latency and severe Doppler effect.
Synthesis, performance and working mechanism of a novel polyaryl ether superplasticizer for cement-based materials (2019)

Synthesis of polyaryl ether (PAE), poly(salicylic acid)-co-poly[p-methylphenyl oxy poly(ethylene glycol) ether] by condensation polymerization and its properties in cement pastes are discussed. The synthesized PAE copolymer was characterized by proton nuclear magnetic resonance (1H NMR) and gel permeation chromatography (GPC). It was proved that PAE could be applied as a high-performance superplasticizer like conventional polycarboxylate ether (PCE). The performances of PAE in cement pastes were tested by the experiments of fluidity, clay tolerance, adsorption, setting time, cement hydration heat, X-ray diffraction (XRD), and its working mechanism was proposed through zeta potential and adsorbed layer thickness analysis. This research can provide useful guidance for the exploration of novel PCE-type superplasticizers in future studies.
Empirical Therapy for Symptomatic Gastroesophageal Reflux Disease in Primary Care: Determinants of Efficacy (2007)

Empirical treatment of typical symptomatic GERD by GPs is highly successful. Predictors of nonresponsiveness to empirical therapy are the presence of alarm symptoms, alcohol consumption and failure of or recurrence after a previous treatment.
Stimulation by Mn2+ and inhibition by Cd2+, Zn2+, Ni2+, and Co2+ ions of luteinizing hormone exocytosis at an intracellular site. (1993)

Direct intracellular effects of the divalent cations Mn2+, Cd2+, Co2+, Ni2+, and Zn2+ on pituitary hormone exocytosis in a permeabilized cell system have not previously been investigated. We examined the effects of these ions on LH exocytosis in primary sheep pituitary cells permeabilized with Staphylococcal alpha-toxin. Mn2+ ions strongly stimulated LH release from permeabilized, but not intact, cells. Mn(2+)-stimulated LH release was ATP-dependent and sensitive to N-ethyl maleimide, indicating that it represents true exocytosis. Hormone release triggered by Ca2+ was inhibited by Cd2+, Zn2+, Co2+, and Ni2+ ions. Half-maximal inhibition of Ca(2+)-stimulated LH release was observed with 10 microM Cd2+, 30 microM Zn2+, 0.3 mM Co2+, and 1 mM Ni2+. With the same order of potency these ions inhibited LH release stimulated by Ba2+, Mn2+, or phorbol ester plus cAMP, suggesting that they inhibit exocytosis at an intracellular site common to all these stimuli.
A New Method for Design of Robust Digital Circuits (2005)

As technology continues to scale beyond 100 nm, there is a significant increase in performance uncertainty of CMOS logic due to process and environmental variations. Traditional circuit optimization methods assuming deterministic gate delays produce a flat "wall" of equally critical paths, resulting in variation-sensitive designs. This paper describes a new method for sizing of digital circuits, with uncertain gate delays, to minimize their performance variation leading to a higher parametric yield. The method is based on adding margins on each gate delay to account for variations and using a new "soft maximum" function to combine path delays at converging nodes. Using analytic models to predict the means and standard deviations of gate delays as polynomial functions of the device sizes, we create a simple, computationally efficient heuristic for uncertainty-aware sizing of digital circuits via geometric programming. Monte-Carlo simulations on custom 32 bit adders and ISCAS'85 benchmarks show that about 10 % to 20 % delay reduction over deterministic sizing methods can be achieved, without any additional cost in area.
Design of Mars global longitudinal coverage constellation leveraging resonant and periodic orbits in Mars-Phobos-Deimos system (2023)

Over the last decades, the exploration of Phobos and Deimos has acquired relevance from both scientific and human missions standpoint. Both moons can play a key role on supporting the Martian Exploration program improving teleoperation capabilities and infrastructure support. The purpose of this work is to propose a different approach to the problem of global longitudinal coverage of Mars, exploiting the characteristic of natural satellites of the planet itself. The proposed constellation can be an alternative to the Mars Areostationary Orbit (MAO), in fact, three satellites equally spaced at Deimos height are enough to provide global longitudinal coverage, with a reduced cost. The main source of perturbation at areostationary height is due to the second degree, second order sectorial harmonic of Mars gravitational field ( J 2 , 2 ), which requires high maintenance cost for an equivalent configuration in MAO. By leveraging Lyapunov orbits in the Mars-Deimos perturbed Three Body Problem , it’s possible to achieve long term stable orbits with lower cost, as well as ballistic orbits with bounded variations . The characteristics and the performance of the constellation are analyzed, as well as the transfer orbits between the Mars-Deimos Lagrange points leveraging resonant orbits. The possibility of placing an extra satellite in an orbit around Phobos with the purpose of increasing performance is also detailed, as well as the transfer trajectory from the Deimos L 3 point to a DRO orbit around Phobos.
New Developments in the Molecular Mechanisms of Pancreatic Tumorigenesis (2017)

Pancreatic cancer is an aggressive disease with a dismal prognosis in dire need of novel diagnostic and therapeutic approaches. The past decade has witnessed an explosion of data on the genetic alterations that occur in pancreatic cancer, as comprehensive next-generation sequencing analyses have been performed on samples from large cohorts of patients. These studies have defined the genomic landscape of this disease and identified novel candidates whose mutations contribute to pancreatic tumorigenesis. They have also clarified the genetic alterations that underlie multistep tumorigenesis in precursor lesions and provided insights into clonal evolution in pancreatic neoplasia. In addition to these important insights into pancreatic cancer biology, these large scale genomic studies have also provided a foundation for the development of novel early detection strategies and targeted therapies. In this review, we discuss the results of these comprehensive sequencing studies of pancreatic neoplasms, with a particular focus on how their results will impact the clinical care of patients with pancreatic cancer.
Energy Loss Structure in X-Ray Photoemission Spectra of Single Crystalline LiNbO3, LiTaO3, MgO and α-Al2O3 (1997)

The energy loss structure in X-ray photoemission spectra was studied in detail for complicated band structure systems ( LiNbO 3 and LiTaO 3 ) and simple band structure systems (MgO and α- Al 2 O 3 ). The energy loss structure on the lower kinetic energy side of core lines can be approximated by a sum of four components. The narrower peaks positioned at 7.0, 12.0 and 14.5 eV for LiNbO 3 , those at 8.0, 13.4 and 15.8 eV for LiTaO 3 , those at 11.3, 15.3 and 18.3 eV for MgO, and that at 14.5 eV for α- Al 2 O 3 were assigned to interband transitions from the valence to the conduction bands. The peak positioned at 35.3 eV for α- Al 2 O 3 was assigned to interband transition from the O2 s level to the conduction band. The broader peaks positioned at 21.8 eV for LiNbO 3 , 22.6 eV for LiTaO 3 , 23.2 eV for MgO, and 25.2 eV for α- Al 2 O 3 were ascribed to the single loss of the bulk plasmon excitation. The peak positioned at 49.9 eV for α- Al 2 O 3 was ascribed to the double losses of the plasmon excitation. The observed plasmon energies are larger than the estimated one in the free electron gas model for each substance (10 eV for the complicated and 1 eV for the simple systems).
Acute fluctuating neurological deficits after pulmonary vein isolation: unmasking a rare complication due to spontaneous spinal subdural bleeding: a case report (2019)

We describe the first case of a spontaneous spinal bleeding following PVI. Given the gradual diffusion of PVI to treat AF in more clinically complex patients with a larger range of comorbidities, particular consideration should be given to seek predisposing bleeding factors in order to assess the risk for neurological complications.
Table S2 from Induced Telomere Damage to Treat Telomerase Expressing Therapy-Resistant Pediatric Brain Tumors (2023)

&lt;p&gt;IC50 values (µM) of 6-thio-dG treatment for 7 days in the cell lines used.&lt;/p&gt;
ChemInform Abstract: Hypervalent Sulfur Fluorides and the Design of Liquid Crystals (2016)

Abstract Review: 56 refs.
Vanishing points and 3D lines from omnidirectional video (2002)

The paper describes a system for structure-from-motion using vanishing points and three-dimensional lines extracted from omnidirectional video sequences. Two novel aspects of this work are its deferred initialization of features using noisy observations from multiple, uncertain vantage points, and its use of dynamic programming for efficient 3D line tracking. We show preliminary results from the system for both indoor and outdoor sequences.
The Impact of ACS Sustainable Chemistry & Engineering (2015)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTThe Impact of ACS Sustainable Chemistry & EngineeringD. T. Allen, B.-J. Hwang, P. Licence, T. Pradeep, and B. SubramaniamCite this: ACS Sustainable Chem. Eng. 2015, 3, 7, 1262Publication Date (Web):July 6, 2015Publication History Received19 June 2015Published online6 July 2015Published inissue 6 July 2015https://pubs.acs.org/doi/10.1021/acssuschemeng.5b00549https://doi.org/10.1021/acssuschemeng.5b00549editorialACS PublicationsCopyright © 2015 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views2041Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (150 KB) Get e-AlertscloseSUBJECTS:Chemical engineering and industrial chemistry Get e-Alerts
Data from Dynamic Mathematical Modeling of IL13-Induced Signaling in Hodgkin and Primary Mediastinal B-Cell Lymphoma Allows Prediction of Therapeutic Targets (2023)

&lt;div&gt;Abstract&lt;p&gt;Primary mediastinal B-cell lymphoma (PMBL) and classical Hodgkin lymphoma (cHL) share a frequent constitutive activation of JAK (Janus kinase)/STAT signaling pathway. Because of complex, nonlinear relations within the pathway, key dynamic properties remained to be identified to predict possible strategies for intervention. We report the development of dynamic pathway models based on quantitative data collected on signaling components of JAK/STAT pathway in two lymphoma-derived cell lines, MedB-1 and L1236, representative of PMBL and cHL, respectively. We show that the amounts of STAT5 and STAT6 are higher whereas those of SHP1 are lower in the two lymphoma cell lines than in normal B cells. Distinctively, L1236 cells harbor more JAK2 and less SHP1 molecules per cell than MedB-1 or control cells. In both lymphoma cell lines, we observe interleukin-13 (IL13)-induced activation of IL4 receptor α, JAK2, and STAT5, but not of STAT6. Genome-wide, 11 early and 16 sustained genes are upregulated by IL13 in both lymphoma cell lines. Specifically, the known STAT-inducible negative regulators &lt;i&gt;CISH&lt;/i&gt; and &lt;i&gt;SOCS3&lt;/i&gt; are upregulated within 2 hours in MedB-1 but not in L1236 cells. On the basis of this detailed quantitative information, we established two mathematical models, MedB-1 and L1236 model, able to describe the respective experimental data. Most of the model parameters are identifiable and therefore the models are predictive. Sensitivity analysis of the model identifies six possible therapeutic targets able to reduce gene expression levels in L1236 cells and three in MedB-1. We experimentally confirm reduction in target gene expression in response to inhibition of STAT5 phosphorylation, thereby validating one of the predicted targets. &lt;i&gt;Cancer Res; 71(3); 693–704. ©2010 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
National evaluation of multidisciplinary quality metrics for head and neck cancer (2017)

Five head and neck cancer quality metrics were identified that have substantial variability in adherence and meaningfully impact overall survival. These metrics are appropriate candidates for national adoption. Cancer 2017;123:4372-81. © 2017 American Cancer Society.
One Pot Preparation of 1,3-Dimethyltetrahydroisoquinolines from Their Biosynthetic Diketo Precursors (1986)

Biornimetic reactions modelling the nitrogen incorporation into the monocyclic precursors l of naphthylisoquinoline alkaloids, using pyridoxamine 1%) are described.The condensation of 26 with g, or, more simply, with benzylamine, though not giving a dihydroisoquinoline t, provides an efficient one pot synthesis of already protected 1.3-dimethyltetrahydroisoquinolines 3, by in situ reduction of the resulting isoquinolinium salts 11.--2 -12.All synthetic compounds are racemic.The drawn configuration denotes the relative stereochemistry.13.The selective conversion of to o ccofigurated tetrahydroisoquinolines is under investi-
Peripherally inserted central catheters: a hidden emerging cause of infection outbreaks (2020)

In our institution, between January 2010 and December 2017, 15 140 peripherally inserted central catheters (PICCs) were inserted in 12 314 patients. Using time-series analysis to evaluate the annual historical trend (AHT), we observed a significant increase in bloodstream infections (BSIs; AHT = 24; p < 0.001) and associated deaths (AHT = 3; p 0.02) in patient with PICCs. The risk of experiencing a BSI was significantly higher in patients with PICCs (odds ratio = 9.6; 95% confidence interval, 9.08-10.18; p < 0.001). To reduce PICC-related BSIs and their related mortality, it is important to limit the overuse of PICCs and to implement a 'no PICC' policy by limiting the insertion of PICCs to situations without other available options.
Abstract 1613: Delta-tocotrienol delays the progression of pancreatic intraepithelial neoplasia (PanIN) lesions in a conditional KrasG12D mouse model (2012)

Abstract Background: We have shown that natural vitamin E γ-tocotrienol is the most bioactive tocotrienols in inhibiting the cell proliferation and induction of apoptosis in pancreatic cancer cells as well as in xenograft models. Therefore in this study we evaluated the chronic 12-month feeding of γ-tocotrienol on the prevention of the progression of PanIN lesions in a conditional KrasG12D mouse model. Methods: Offspring of LSLKRASG12D x PDX-1-Cre intercrosses (double positive by genotyping) were randomized to three groups: 1) No treatment (NT), 2) Vehicle (ethanol extracted olive oil, 1.0 ml/kg x 2/ day, PO) and 3) γ-tocotrienol (200 mg/kg x 2/day, PO). The treatment was started at the age of 10 weeks and continued for 12 months. The survival of the mice in three groups was plotted by Kaplan-Meir graph. The pancreas of KRASG12D; PDX-1-Cre mice was analyzed for the presence of murine PanINs. The apoptosis, cell cycle and signaling markers were determined by Western blotting and immunostaining. Results: No significant difference in food intake and body weight gain between γ-tocotrienol and control groups was observed during 12 months feeding. γ-tocotrienol treatment significantly increased survival of mice compared to control groups (p&amp;lt;0.025). Mice fed γ-tocotrienol had a significant delay in the progression of mPanIN lesions. The proportion of mPanIN-3 lesion was significantly decreased (P&amp;lt;0.001), whereas the relative numbers of all other lesions combined were slightly increased in the γ-tocotrienol-fed animals. γ-tocotrienol feeding also inhibited the pMEK and pERK signaling and increased p27Kip1 expression in the pancreatic tumor tissues. The apoptosis markers such as caspase-3, PARP1 cleavage, and Bax expression were increased in tumor tissues of mice treated with γ-tocotrienol compared to controls. NF-κB/p65 and the NF-κB transcriptional targets Bcl-XL was down-regulated by γ-tocotrienol treatment. The ratio of the proapoptotic (Bax) and antiapoptotic (Bcl-XL) proteins was increased almost 4-folds in the pancreatic tumor tissues compared to controls. Conclusion: γ-tocotrienol delays the progression of pancreatic cancer precursor lesions in a preclinical animal model hence warrant it's clinical use for the prevention and treatment of pancreatic cancer in high-risk patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1613. doi:1538-7445.AM2012-1613
Roundtable: Physics in Transition (1993)

The question before us can be stated simply: Where do we go from here? The “we” is the physics community, though it's our hope that the discussion will range more widely into science and technology, so we'll be able to comment on the changes likely to take place in research universities, national laboratories and private industry. Our subject is physics in transition to the 21st century. Some say physics has been in a state of transition for well over a century—certainly since James Clerk Maxwell in the 19th century. In every decade of the 20th century, physics has experienced momentous turning points. In this last decade of the century we seem to have reached another turning point with the end of nuclear weapons rivalry that was given the name of cold war and the increase of global industrial competitiveness. In the past year, pressures by the Federal government and by commercial companies have increased to make physics and the rest of science more relevant to business and to society. We are already witnessing the reduction of physics research at some major corporate laboratories and sensing a shakeup for physics facilities at some national labs. So this discussion of the future of physics is timely.
N-Terminal Region of Cardiac Myosin Binding Protein-C is Necessary for Cardiac Function (2016)

Restricted accessAbstractFirst published online March 1, 2016N-Terminal Region of Cardiac Myosin Binding Protein-C is Necessary for Cardiac FunctionM Sivaguru, TL Lynch, […], DW Kuster, S Govindan, S Sadayappan, MJ Previs, DM Warshaw, K Lee, and R Craig+6-6View all authors and affiliationsVolume 64, Issue 4https://doi.org/10.1136/jim-2016-000120.2