gebhart/patrepeval huggingface dataset:
Diffraction loss of confined modes in microcavities (2002)

In this paper, the loss of a simplified cavity is studied using an accurate numerical model that solves the scalar Helmholtz Equation at each point in the cavity. The idealized cavity geometry consists of two perfect mirrors. The upper mirror is offset inward at some radius as shown, so that the cavity is laterally index guided. A cavity length was chosen to mimic (approximately) the number of standing waves in a vertical cavity surface emitting laser (VCSEL) cavity, including the distributed Bragg mirrors.
Highly Potent Non-Carboxylic Acid Autotaxin Inhibitors Reduce Melanoma Metastasis and Chemotherapeutic Resistance of Breast Cancer Stem Cells (2017)

Autotaxin (ATX, aka. ENPP2) is the main source of the lipid mediator lysophosphatidic acid (LPA) in biological fluids. This study reports on inhibitors of ATX derived by lead optimization of the benzene-sulfonamide in silico hit compound 3. The new analogues provide a comprehensive structure-activity relationship of the benzene-sulfonamide scaffold that yielded a series of highly potent ATX inhibitors. The three most potent analogues (3a, IC<sub>50</sub> ∼ 32 nM; 3b, IC<sub>50</sub> ∼ 9 nM; and 14, IC<sub>50</sub> ∼ 35 nM) inhibit ATX-dependent invasion of A2058 human melanoma cells in vitro. Two of the most potent compounds, 3b and 3f (IC<sub>50</sub> ∼ 84 nM), lack inhibitory action on ENPP6 and ENPP7 but possess weak antagonist action specific to the LPA<sub>1</sub> G protein-coupled receptor. In particular, compound 3b potently reduced in vitro chemotherapeutic resistance of 4T1 breast cancer stem-like cells to paclitaxel and significantly reduced B16 melanoma metastasis in vivo.
Beyond Stereoselectivity, Switchable Catalysis: Some of the Last Frontier Challenges in Ring‐Opening Polymerization of Cyclic Esters (2015)

Metal-based catalysts and initiators have played a pivotal role in the ring-opening polymerization (ROP) of cyclic esters, thanks to their high activity and remarkable ability to control precisely the architectures of the resulting polyesters in terms of molar mass, dispersity, microstructure, or tacticity. Today, after two decades of extensive research, the field is slowly reaching maturity. However, several challenges remain, while original concepts have emerged around new types or new applications of catalysis. This Review is not intended to comprehensively cover all of these aspects. Rather, it provides a personal overview of the very recent progress achieved in some selected, important aspects of ROP catalysis--stereocontrol and switchable catalysis. Hence, the first part addresses the development of new metal-based catalysts for the isoselective ROP of racemic lactide towards stereoblock copolymers, and the use of syndioselective ROP metal catalysts to control the monomer sequence in copolymers. A second part covers the development of ROP catalysts--primarily metal-based catalysts, but also organocatalysts--that can be externally regulated by the use of chemical or photo stimuli to switch them between two states with different catalytic abilities. Current challenges and opportunities are highlighted.
The Kynurenine pathway and cognitive performance in Euthymic bipolar disorder (2012)

Sellgren, Ca; Olsson, SKb; Erhardt, Sb; Engberg, Gb; Lichtenstein, Pa; Landèn, Ma,c Author Information
Wrist-worn pervasive gaze interaction (2016)

This paper addresses gaze interaction for smart home control, conducted from a wrist-worn unit. First we asked ten people to enact the gaze movements they would propose for e.g. opening a door or adjusting the room temperature. On basis of their suggestions we built and tested different versions of a prototype applying off-screen stroke input. Command prompts were given to twenty participants by text or arrow displays. The success rate achieved by the end of their first encounter with the system was 46% in average; it took them 1.28 seconds to connect with the system and 1.29 seconds to make a correct selection. Their subjective evaluations were positive with regard to the speed of the interaction. We conclude that gaze gesture input seems feasible for fast and brief remote control of smart home technology provided that robustness of tracking is improved.
Attenuation of Insulin Action by an Allosteric Insulin Receptor Antibody in Healthy Volunteers (2017)

Single X358 infusions were well tolerated and resulted in a dose-dependent reduction in insulin sensitivity. Clinical development of X358 in hyperinsulinemic, hypoglycemic conditions is proceeding.
Functionalized random copolymers from versatile one‐pot click chemistry/ATRP tandems approaches (2009)

Abstract Two complementary tandem strategies based on the one‐pot combination of click chemistry and atom transfer radical polymerization (ATRP) are studied. Initially, functionalized random copolymers are obtained by copolymerization of methyl methacrylate and propargyl methacrylate simultaneously to the click chemistry coupling of a monofunctional azide. Then, an approach based on the copolymerization of methyl methacrylate and 11‐azido‐undecanoyl methacrylate simultaneously to the click chemistry coupling of a monofunctional alkyne is also investigated. For both the approach, polymerization and click chemistry coupling are catalyzed by CuBr and bipyridine (Bipy) in diphenylether at 90 °C. The [Bipy]/[CuBr] ratio is varied from 2 to 25 and the ratio of functionalized comonomer from 20 to 70 mol %. Both the tandem strategies proceed with good yields (50–80%) and allow a good control over the characteristics of the resulting random copolymers and macromolecular brushes ( M n ∼ 15,000–40,000 g/mol and PDI ∼ 1.3–2.0) as well as quantitative click functionalization as characterized by 1 H NMR and size exclusion chromatography analyses. Although the click process is generally completed at the early stage of the process, the rate of polymerization depends on the amount of bipyridine involved. It was found that extending most of the polymerization process out of the click reaction regime results in a better control of the polymerization, preventing the significant occurrence of side reactions. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 3803–3813, 2009
Adaptive TTL-Based Caching for Content Delivery (2018)

Content delivery networks (CDNs) cache and serve a majority of the user-requested content on the Internet. Designing caching algorithms that automatically adapt to the heterogeneity, burstiness, and non-stationary nature of real-world content requests is a major challenge and is the focus of our work. While there is much work on caching algorithms for stationary request traffic, the work on non-stationary request traffic is very limited. Consequently, most prior models are inaccurate for non-stationary production CDN traffic. We propose two TTL-based caching algorithms that provide provable performance guarantees for request traffic that is bursty and nonstationary. The first algorithm called d-TTL dynamically adapts a TTL parameter using stochastic approximation. Given a feasible target hit rate, we show that d-TTL converges to its target value for a general class of bursty traffic that allows Markov dependence over time and non-stationary arrivals. The second algorithm called f-TTL uses two caches, each with its own TTL. The first-level cache adaptively filters out non-stationary traffic, while the second-level cache stores frequently-accessed stationary traffic. Given feasible targets for both the hit rate and the expected cache size, f-TTL asymptotically achieves both targets. We evaluate both d-TTL and f-TTL using an extensive trace containing more than 500 million requests from a production CDN server. We show that both d-TTL and f-TTL converge to their hit rate targets with an error of about 1.3%. But, f-TTL requires a significantly smaller cache size than d-TTL to achieve the same hit rate, since it effectively filters out non-stationary content.
Loss of Hsp70 Exacerbates Pathogenesis But Not Levels of Fibrillar Aggregates in a Mouse Model of Huntington's Disease (2009)

Endogenous protein quality control machinery has long been suspected of influencing the onset and progression of neurodegenerative diseases characterized by accumulation of misfolded proteins. Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expansion of a polyglutamine (polyQ) tract in the protein huntingtin (htt), which leads to its aggregation and accumulation in inclusion bodies. Here, we demonstrate in a mouse model of HD that deletion of the molecular chaperones Hsp70.1 and Hsp70.3 significantly exacerbated numerous physical, behavioral and neuropathological outcome measures, including survival, body weight, tremor, limb clasping and open field activities. Deletion of Hsp70.1 and Hsp70.3 significantly increased the size of inclusion bodies formed by mutant htt exon 1, but surprisingly did not affect the levels of fibrillar aggregates. Moreover, the lack of Hsp70s significantly decreased levels of the calcium regulated protein c-Fos, a marker for neuronal activity. In contrast, deletion of Hsp70s did not accelerate disease in a mouse model of infectious prion-mediated neurodegeneration, ruling out the possibility that the Hsp70.1/70.3 mice are nonspecifically sensitized to all protein misfolding disorders. Thus, endogenous Hsp70s are a critical component of the cellular defense against the toxic effects of misfolded htt protein in neurons, but buffer toxicity by mechanisms independent of the deposition of fibrillar aggregates.
Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments (2016)

Efficient syntheses of chiral fragments derived from chiral amino alcohols are described. Several unique scaffolds were readily accessed in 1-5 synthetic steps leading to 45 chiral fragments, including oxazolidinones, morpholinones, lactams, and sultams. These fragments have molecular weights ranging from 100 to 255 Da and are soluble in water (0.085 to >15 mM).
Histopathological Prognostic Factors Influencing Long-Term Prognosis After Surgical Resection for Hepatic Metastases From Colorectal Cancer (1999)

Our results suggest that our proposed new histopathological features of hepatic metastases were good predictors of prognosis after surgical resection for hepatic metastases from colorectal cancer. Especially, infiltrative growth of hepatic tumor is strongly correlated with a poor prognosis after hepatectomy.
Adaptive beamformer for spherical eigenbeamforming microphone arrays (2014)

Spherical eigenbeamforming microphone arrays have become a subject of interest in recent years [1-6]. General beampattern design and implementation are simplified due to the decomposition of the soundfield into orthonormal spherical harmonic (SH) “building block” eigenbeams. Eigenbeams are then combined to realize the beamformer. In this paper we present a remarkably straightforward and computationally simple adaptive beamformer. The beamformer algorithm exploits a fundamental non-negativity property of the combination of zero-order SH eigenbeams to realize an implicit constraint for the adaptive spherical eigenbeamformer.
TERRA-Reinforced Association of LSD1 with MRE11 Promotes Processing of Uncapped Telomeres (2014)

Telomeres protect chromosome ends from being recognized as sites of DNA damage. Upon telomere shortening or telomere uncapping induced by loss of telomeric repeat-binding factor 2 (TRF2), telomeres elicit a DNA-damage response leading to cellular senescence. Here, we show that following TRF2 depletion, the levels of the long noncoding RNA TERRA increase and LSD1, which binds TERRA, is recruited to telomeres. At uncapped telomeres, LSD1 associates with MRE11, one of the nucleases implicated in the processing of 3' telomeric G overhangs, and we show that LSD1 is required for efficient removal of these structures. The LSD1-MRE11 interaction is reinforced in vivo following TERRA upregulation in TRF2-deficient cells and in vitro by TERRA-mimicking RNA oligonucleotides. Furthermore, LSD1 enhances the nuclease activity of MRE11 in vitro. Our data indicate that recruitment of LSD1 to deprotected telomeres requires MRE11 and is promoted by TERRA. LSD1 stimulates MRE11 catalytic activity and nucleolytic processing of uncapped telomeres.
Remote Detection of Hydrocarbon Filled Layers Using Marine Controlled Source Electromagnetic Sounding (2002)

D-08 REMOTE DETECTION OF HYDROCARBON FILLED LAYERS USING MARINE CONTROLLED SOURCE ELECTROMAGNETIC SOUNDING 1 T. EIDESMO 1 S. ELLINGSRUD 1 L.M.MACGREGOR 3 S. CONSTABLE 2 M.C.SINHA 3 S. JOHANSEN 4 H. WESTERDAHL 5 and F.N.KONG 5 Introduction Measurements of sub-seafloor electrical resistivity obtained by wire line logging of wells have traditionally played a crucial role in hydrocarbon exploration and reservoir assessment and development. However there are clear advantages to developing non-invasive geophysical methods capable of providing similar information albeit at a lower vertical resolution. The vast saving in terms of avoiding the costs of drilling test wells into structures that
Abstract C114: Clinical response to a lapatinib-based therapy of a Li-Fraumeni Syndrome patient with a novel HER2-V659E mutation. (2013)

Abstract Genomic characterization of recurrent breast and lung tumors developed over the course of 10 years in a 29-year-old patient with a germline p53 mutation (Li-Fraumeni Syndrome) identified oncogenic alterations in the HER2 and EGFR genes across all tumors, including HER2 amplifications, an EGFR-exon 20 insertion, and the first-in-human HER2-V659E mutation showing a phenotypic convergent evolution towards HER2 and EGFR alterations. Following the identification of HER2-activating events in the most recent lung carcinoma and in circulating tumor cells, we treated the reminiscent metastatic lesions with a lapatinib-based therapy. A clinical response both symptomatic and radiologic was achieved. HER2-V659E sensitivity to lapatinib was confirmed in the laboratory. Citation Information: Mol Cancer Ther 2013;12(11 Suppl):C114. Citation Format: Violeta Serra, Ana Vivancos, Xose Puente, Enriqueta Felip, Daniel Silberschmidt, Ginevra Caratù, Josep-Lluis Parra, Leticia De Mattos-Arruda, Judit Grueso, Javier Hernández-Losa, Joaquín Arribas, Ludmila Prudkin, Paolo Nuciforo, Maurizio Scaltriti, Joan Seoane, José Baselga. Clinical response to a lapatinib-based therapy of a Li-Fraumeni Syndrome patient with a novel HER2-V659E mutation. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr C114.
Polyvalent Oligonucleotide Gold Nanoparticle Conjugates as Delivery Vehicles for Platinum(IV) Warheads (2010)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionPolyvalent Oligonucleotide Gold Nanoparticle Conjugates as Delivery Vehicles for Platinum(IV) WarheadsShanta Dhar, Weston L. Daniel, David A. Giljohann, Chad A. Mirkin*, and Stephen J. Lippard*Cite this: J. Am. Chem. Soc. 2010, 132, 48, 17335Publication Date (Web):November 5, 2010Publication History Published online5 November 2010Published inissue 8 December 2010https://pubs.acs.org/doi/10.1021/ja109134jhttps://doi.org/10.1021/ja109134jcorrectionACS PublicationsCopyright © 2010 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views2635Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (257 KB) Get e-AlertscloseSUBJECTS:Biopolymers,Fluorescence,Immunology,Nucleic acid structure,Peptides and proteins Get e-Alerts
Fluorinated Benzofuran Derivatives for PET Imaging of β-Amyloid Plaques in Alzheimer's Disease Brains (2010)

A series of fluorinated benzofuran derivatives as potential tracers for positron emission tomography (PET) targeting β-amyloid plaques in the brains of patients with Alzheimer's disease (AD) were synthesized and evaluated. The derivatives were produced using an intramolecular Wittig reaction. In experiments in vitro, all displayed high affinity for Aβ(1-42) aggregates with K i values in the nanomolar range. Radiofluorinated 17, [(18)F]17, in particular labeled β-amyloid plaques in sections of Tg2576 mouse brain and displayed high uptake (5.66% ID/g) at 10 min postinjection, sufficient for PET imaging. In addition, in vivo β-amyloid plaque labeling can be clearly demonstrated with [(18)F]17 in Tg2576 mice. In conclusion, [(18)F]17 may be useful for detecting β-amyloid plaques in patients with AD.
Design and assembly of a static magnetic field generator for Lorentz Field Electrical Impedance Tomography (2016)

In Lorentz Field Electrical Impedance Tomography (LFEIT), ultrasound waves are transmitted to a tissue under static magnetic field. Magnetic fields of currents generated in boundaries where conductivity difference exists because of vibrations are measured with coils. In this study, a static magnetic field is created with permanent magnets and magnetic core for LFEIT. The contribution of magnetic core to the created magnetic flux density is demonstrated. Based on these simulation studies magnetic core is designed. To safely assemble the magnets and the core, force and torque calculations are performed in COMSOL Multiphysics. Consequently based on these calculations appropriate devices are designed for the assembly. The distribution of magnetic flux density in the air gap of core is evaluated numerically and experimentally. The relative error of magnetic flux density between the numerical and experimental values is provided. The maximum relative error is around 10.47% among 120 points where magnetic flux density is measured.
Supplementary Movie 8 from Ovarian Cancer Spheroids Use Myosin-Generated Force to Clear the Mesothelium (2023)

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Rocky Mountain spotted fever vaccine in an animal model. (2020)

Formalin-killed, purified Rickettsia rickettsii vaccine was evaluated in a guinea pig model of R. rickettsii infection. Vaccinated guinea pigs were partially protected by the vaccine when challenged with virulent, viable rickettsiae. Greater protection was observed when higher doses of vaccine were given and when frequent booster injections were administered. Stimulation of cell-mediated immunity to the vaccine antigens was variable and also appeared to be achieved more reproducibly with booster vaccinations. Serum antibody was elicited by high doses of vaccine and by booster vaccinations. The presence of serum antibody was useful in predicting immunity to challenge with R. rickettsii.
Glofitamab, a Novel, Bivalent CD20-Targeting T-Cell–Engaging Bispecific Antibody, Induces Durable Complete Remissions in Relapsed or Refractory B-Cell Lymphoma: A Phase I Trial (2021)

In patients with predominantly refractory, aggressive B-NHL, glofitamab showed favorable activity with frequent and durable CRs and a predictable and manageable safety profile.
Relapse After Response to Interleukin-2-Based Immunotherapy: Patterns of Progression and Response to Retreatment (1991)

The initial site of disease relapse was identified for 79 patients with metastatic renal cell cancer (RCC), melanoma, colon cancer, or non-Hodgkin's lymphoma (NHL), who had achieved partial or complete responses to one of five IL-2-based immunotherapy regimens. The initial site of relapse was evenly distributed between pre-existing sites of disease (33%), new sites of disease (38%), or both (29%). There was no difference in the distribution of recurrences between patients with partial or complete responses. Fifty-one patients with prior complete or partial responses were retreated with additional IL-2-based therapy following tumor progression. Five of 51 patients retreated following relapse developed new partial responses. There were no complete responses. Three patients with NHL were retreated with IL-2 and LAK cells and all achieved a second response, while only 2 of 48 patients with other histologic diagnoses reresponded. It is concluded that after a partial or complete response to IL-2-based immunotherapy, patients who relapse do so equally at new and pre-existing sites of disease. A response to retreatment following tumor progression may be attained in patients with NHL, while a new response is unlikely for patients with melanoma and RCC.
Statistical Analysis of Method Comparison Data: Testing Normality (1979)

A Lilliefors test of normality has been applied to data from precision and accuracy studies. Most data sets tested as non-normal. Simulation studies showed that the test is extremely sensitive to the rounded, narrowly distributed data that are typical of method performance studies in clinical chemistry. The Lilliefors test can be modified to be applicable to rounded data so that it gives fewer indications of non-normality. The authors conclude that the selection of a test of normality requires careful study of the properties of the test. Otherwise, the subsequent choice between parametric and nonparametric statistics may not be meaningful.
ChemInform Abstract: THE DETERMINATION OF ENANTIOMERIC PURITY USING CHIRAL LANTHANIDE SHIFT REAGENTS (1974)

Abstract Tris‐Chelate von Eu(III) mit chiralen β‐Diketonen verschieben entsprechende NMR‐ Resonanzen vieler enantiomerer organischer Substanzen in unterschiedlichem Umfang.
Combined Self-Collected Anterior Nasal and Oropharyngeal Specimens versus Provider-Collected Nasopharyngeal Swabs for the Detection of SARS-CoV-2 (2020)

The U.S. Food and Drug Administration (FDA) and Centers for Disease Control interim guidelines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing list the patient self-collected anterior nares swab (ANS) as an acceptable alternative to the standard health care provider (HCP)-collected nasopharyngeal swab (NPS) (1, 2). Self-collected ANS minimizes HCP exposure to infectious aerosols, thus reducing the need for high-level personal protective equipment. Self-collection using ANS may also be more comfortable for the patient. However, published reports have observed variable ANS sensitivities compared to NPS (3–5). We previously observed that self-collected ANS missed 15% of positive detections compared to NPS or saliva (6) and hypothesized that self-collected swabs from multiple anatomic sites may improve diagnostic sensitivity.