gebhart/patrepeval huggingface dataset:
Elaborate Ligand-Based Modeling Coupled with Multiple Linear Regression and k Nearest Neighbor QSAR Analyses Unveiled New Nanomolar mTOR Inhibitors (2013)

The mammalian target of rapamycin (mTOR) has an important role in cell growth, proliferation, and survival. mTOR is frequently hyperactivated in cancer, and therefore, it is a clinically validated target for cancer therapy. In this study, we combined exhaustive pharmacophore modeling and quantitative structure-activity relationship (QSAR) analysis to explore the structural requirements for potent mTOR inhibitors employing 210 known mTOR ligands. Genetic function algorithm (GFA) coupled with k nearest neighbor (kNN) and multiple linear regression (MLR) analyses were employed to build self-consistent and predictive QSAR models based on optimal combinations of pharmacophores and physicochemical descriptors. Successful pharmacophores were complemented with exclusion spheres to optimize their receiver operating characteristic curve (ROC) profiles. Optimal QSAR models and their associated pharmacophore hypotheses were validated by identification and experimental evaluation of several new promising mTOR inhibitory leads retrieved from the National Cancer Institute (NCI) structural database. The most potent hit illustrated an IC50 value of 48 nM.
Novel Size Effect of LaMnO3+δ Nanocrystals Embeded in SBA-15 Mesoporous Silica (2006)

LaMnO 3+δ nanocrystals with a mean diameter of 75 Å, were synthesized using SBA-15 mesoporous silica. The magnetic properties of the nanocrystals showed a novel size effect and were quite different from those of bulk crystal. The magnetic and electron spin resonance measurement results indicate that the existence of two transition temperatures, 278 and 235 K, which are higher than Néel and Curie temperature of bulk LaMnO 3+δ . The ESR spectrum was observed even at the lower transition temperature and consisted of the two broad lines whose shape changed at each transition temperature. The magnetization curve at 77 K was well reproduced by the summation of the two superparamagnetic magnetizations corresponding to antiferromagnetic and ferromagnetic nanoparticles, respectively. These results suggest that there are noninteracting ferromagnetic and antiferromagnetic nanoparticles with transition temperatures of 278 and 235 K, respectively.
ChemInform Abstract: Intramolecular Diels‐Alder Reactions of 2H‐Thiopyran Dienes. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
INDUCTION OF APOPTOSIS BY A MHC CLASS II DERIVED PEPTIDE THROUGH A CASPASE INDEPENDENT PATHWAY. (2000)

Qingsheng, Jiao1; Yu, Joyce1; Carpenter, Charles B.2; Sayegh, Mohamed H.2; Murphy, Barbara1 Author Information
High Frequency Performance of Graphene Transistors Grown by Chemical Vapor Deposition for Mixed Signal Applications (2011)

This paper demonstrates high frequency performance of graphene transistors grown by chemical vapor deposition on copper foils. Using Ti/Pd/Au-based ohmic contacts and a hybrid gate dielectric stack of 5 nm SiO2 and 15 nm Al2O3 grown by atomic layer deposition, graphene transistors with an extrinsic current-gain cut-off frequency (fT) of 2 GHz and power-gain cut-off frequency, fmax, of 5.6 GHz were obtained for a gate length of Lg = 1.6 µm. By applying a bias to the Si substrate the access resistances are reduced, which improved the fT and fmax in the devices to 3.5 and 6.5 GHz, respectively. Finally we demonstrate these devices in a real-application circuit for binary-phase shift keying.
ChemInform Abstract: 2,6‐Dimethyl‐4‐nitrobenzoic Anhydride (DMNBA): An Effective Coupling Reagent for the Synthesis of Carboxylic Esters and Lactones. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
From plastic to pixels (2012)

research-article From plastic to pixels: in search of touch-typing touchscreen keyboards Share on Authors: Leah Findlater University of Maryland, College Park University of Maryland, College ParkView Profile , Jacob O. Wobbrock University of Washington University of WashingtonView Profile Authors Info & Claims InteractionsVolume 19Issue 3May + June 2012 pp 44–49https://doi.org/10.1145/2168931.2168942Online:01 May 2012Publication History 13citation1,525DownloadsMetricsTotal Citations13Total Downloads1,525Last 12 Months148Last 6 weeks15 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Anterolateral Dynamized Instrumentation and Fusion for Unstable Thoracolumbar and Lumbar Burst Fractures (1997)

Dynamized load-sharing anterolateral Cotrel-Dubousset instrumentation led to solid bone graft healing without implant failure by allowing continual compression while deterring shear and rotational stresses.
Sliceable bandwidth variable transponders for elastic optical networks: the idealist vision (2015)

&amp;lt;p&amp;gt;This paper describes the general architecture for a sliceable bandwidth variable transponder as identified within the IDEALIST European project. The capability of generate super-channels (optical connections with several adjacent optical sub-carriers) and the slice-ability (super-channels generated together but independently routed in the network towards different destinations) are the key elements of the considered architecture.&amp;lt;/p&amp;gt;
Polymer-Supported Reagents as Versatile Tools in Combinatorial Chemistry and Total Synthesis (2000)

The growing speed of biological evaluation of potential drug substances during the past years has imposed the need to develop new methods for the fast and efficient generation of new chemical entities. In general, chemical libraries containing large numbers of compounds may be prepared either on polymer supports or in solution. The use of supported reagents combines the advantages of polymer-supported reactions (e.g. allowing the application of a large excess of the reagent without the need for additional purification steps) with the benefits of solution phase chemistry (e.g. the ease of monitoring the progress of the reaction by simply applying LC-MS or TLC techniques). While, many solid-supported reagents have been described, only a few have been used in combinatorial chemistry. Furthermore, multi-step sequences using polymer-supported reagents are rare, although there is a growing interest in sequestering agents on solid supports. Recent work in our group has focussed on the development of orchestrated multi-step methods using polymer-supported reagents for the preparation of chemical compound libraries.
CdSe/CdSe1–xTex Core/Crown Heteronanoplatelets: Tuning the Excitonic Properties without Changing the Thickness (2017)

Here we designed and synthesized CdSe/CdSe1–xTex core/crown nanoplatelets (NPLs) with controlled crown compositions by using the core-seeded-growth approach. We confirmed the uniform growth of the crown regions with well-defined shape and compositions by employing transmission electron microscopy, X-ray photoelectron spectroscopy, and X-ray diffraction. By precisely tuning the composition of the CdSe1–xTex crown region from pure CdTe (x = 1.00) to almost pure CdSe doped with several Te atoms (x = 0.02), we achieved tunable excitonic properties without changing the thickness of the NPLs and demonstrated the evolution of type-II electronic structure. Upon increasing the Te concentration in the crown region, we obtained continuously tunable photoluminescence peaks within the range of ∼570 nm (for CdSe1–xTex crown with x = 0.02) and ∼660 nm (for CdSe1–xTex crown with x = 1.00). Furthermore, with the formation of the CdSe1–xTex crown region, we observed substantially improved photoluminescence quantum yields (up to ∼95%) owing to the suppression of nonradiative hole trap sites. Also, we found significantly increased fluorescence lifetimes from ∼49 up to ∼326 ns with increasing Te content in the crown, suggesting the transition from quasi-type-II to type-II electronic structure. With their tunable excitonic properties, this novel material presented here will find ubiquitous use in various efficient light-emitting and -harvesting applications.
A voltage scaling model for performance evaluation in digital CMOS circuits (2009)

We present an easy to use method to extrapolate digital circuit performance and power from nominal to worst-case operating conditions. It allows the circuit designer to explore the design space over a continuous rage of voltages and temperatures and for different process conditions. Voltage scaling is identified as a key challenge for the 22 nm technology node.
Ontological reasoning for consistency in the design of cyber-physical systems (2016)

The design of Cyber-Physical Systems (CPS) involves a multitude of stakeholders. Each of these stakeholders has a specific view on the system under design. Unfortunately, when designers create artefacts in their different views in a concurrent manner, the integration of the different views may reveal inconsistencies. This leads to time consuming, iterative design processes where inconsistencies are resolved, in turn possibly creating new ones. It is hence necessary to reason explicitly about the view-specific properties that depend on, and influence properties of other views. This enables consistency during integration and reduces the development time and effort. In this paper we formalise the interrelationships between the different views, in the context of different design processes, to allow designers to meaningfully and efficiently manage inconsistencies. Our formalisation introduces ontological domain properties and their relations as the link between the view-specific properties used by the stakeholders. Thus, our approach combines the state of the art of Model-Based Systems Engineering (MBSE) and Semantic Web. The relevance of this approach is demonstrated by means of a motivating example.
ChemInform Abstract: Enzymes in Organic Synthesis. Part 15. Short Enzymatic Synthesis of L‐Fucose Analogues. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
075 Effect of Polyhydrated Ionogen (PHI) on Viability and Matrix Metalloproteinase Levels in Medium of Cultured Cells (2008)

It has been postulated that elevated levels of matrix metalloproteinases (MMPs) and reactive oxygen species detected in fluids and biopsies of chronic wounds contribute to the failure of wound to heal by degrading essential growth factors, receptors and extracellular matrix proteins. This stimulated the development of a formulation containing metal ions (polyhydrated ionogen or PHI) and citric acid that reduced reactive oxygen species in cultures of polymorphonuclear leukocytes (J Wound Care 12:10, 2003). The effect of PHI on synthesis of MMPs was studied in cultures of tumor cells and human dermal fibroblasts. Dose response curves of PHI ranging from 0.02% to 10%(W/V) established no toxicity in cultures of human dermal fibroblasts after 24 hours of incubation with PHI at concentrations below 1.25%, as measured by MTT assay. Levels of MMP-2 activity measured by antibody capture assay were reduced approximately 80% in culture medium of Mor-86 glioma tumor cells after 24 hours of exposure to 1% PHI. These results suggest that PHI reduced the synthesis of MMP-2 protein, presumably by reducing transcription and/or translation of MMP-2 gene. Clinical case reports of chronic wounds treated by PHI dressing (DerMax) suggest that PHI treatment stimulated healing and reduced MMP-2 immunostaining in biopsies of the chronic wounds. Acknowledgment: This research was supported by Greystone Medical Group.
Analysis of electromagnetic scattering from doubly periodic arrays of penetrable bodies using a patch‐dipole current model (1991)

A novel solution is presented for the problem of three‐dimensional electromagnetic scattering of a time‐harmonic plane wave from a doubly periodic infinite array of disjoint finite‐size penetrable bodies. A set of fictitious doubly periodic and properly modulated patches of magnetic current of cross polarization is used to simulate the scattered field. A set of fictitious elemental lectric dipoles of cross polarization is used to simulate the field inside the penetrable bodies. The complex amplitudes of the two sets of fictitious sources are adjusted to render the tangential components of the electric and magnetic fields continuous at a selected set of points on the surface of any of the scatterers. The suggested solution procedure is simple to implement and is applicable to doubly periodic arrays composed of homogeneous bodies of smooth, but otherwise arbitrary, shape. The accuracy of the method has been demonstrated by means of several accuracy checks. It has also been shown that in the limiting case of widely spaced spherical scatterers the numerical solution agrees well with an approximate analytic solution.
Glioblastoma Stem Cells Are Regulated by Interleukin-8 Signaling in a Tumoral Perivascular Niche (2013)

Glioblastoma multiforme contains a subpopulation of cancer stem-like cells (CSC) believed to underlie tumorigenesis and therapeutic resistance. Recent studies have localized CSCs in this disease adjacent to endothelial cells (EC) in what has been termed a perivascular niche, spurring investigation into the role of EC-CSC interactions in glioblastoma multiforme pathobiology. However, these studies have been limited by a lack of in vitro models of three-dimensional disease that can recapitulate the relevant conditions of the niche. In this study, we engineered a scaffold-based culture system enabling brain endothelial cells to form vascular networks. Using this system, we showed that vascular assembly induces CSC maintenance and growth in vitro and accelerates tumor growth in vivo through paracrine interleukin (IL)-8 signaling. Relative to conventional monolayers, endothelial cells cultured in this three-dimensional system not only secreted enhanced levels of IL-8 but also induced CSCs to upregulate the IL-8 cognate receptors CXCR1 and CXCR2, which collectively enhanced CSC migration, growth, and stemness properties. CXCR2 silencing in CSCs abolished the tumor-promoting effects of endothelial cells in vivo, confirming a critical role for this signaling pathway in GMB pathogenesis. Together, our results reveal synergistic interactions between endothelial cells and CSCs that promote the malignant properties of CSCs in an IL-8-dependent manner. Furthermore, our findings underscore the relevance of tissue-engineered cell culture platforms to fully analyze signaling mechanisms in the tumor microenvironment.
Underwater low frequency Helmholtz bubble resonator (2022)

Low-frequency sound sources have found application in oceanology and geoacoustic methods of remote sensing. An underwater low-frequency sound source with a pneumatically driven bubble resonator covered with an elastic membrane effectively provides a very high source level. However, it has a narrow bandwidth, and its resonant frequency is difficult to change without changing the size of the original system. Internal acoustic resonators included in a bubble filled with gas can change the frequency response of the entire source and expand its bandwidth. Internal resonant systems can be designed so that the bubble resonator can be tuned over a wide frequency range. Other systems may add one or more internal resonances and spread the emitted spectrum over a very wide frequency band. It is possible to consider various multipole resonant systems in combination with an underwater bubble. A simple and efficient system consists of a bubble resonator and an internal Helmholtz resonator. The addition of a Helmholtz resonator converts the single resonant bubble into a double resonant system and extends its bandwidth. The theory of the underwater bubble Helmholtz resonator and various applications of these resonators for practical systems are considered. The results of the experimental verification are discussed.
Annotating text using the linguistic description scheme of MPEG-7 (2006)

We describe the way we adapted a text analysis tool for annotating with the Linguistic Description Scheme of MPEG-7 text related to and extracted from multimedia content. Practically applied in the DIRECT-INFO EC R&D project we show how such linguistic annotation contributes to semantic annotation of multimodal analysis systems, demonstrating also the use of the XML schema of MPEG-7 for supporting cross-media semantic content annotation.
A Shaker Rig-Based Testing of Perceived Ride Comfort for Various Configurations of Active Suspensions (2020)

Abstract Benefits of introducing active suspension in autonomous vehicles in terms of improving the driver's work/leisure ability can be tested under laboratory conditions using a high-performance shaker rig. In this paper, five different suspension configurations, including passive, semi-active, and fully active suspensions (FAS) and related optimal controls with or without road preview information, are implemented in vehicle dynamics simulator. They are experimentally examined having the driver in the loop to obtain objective and subjective measures of ride comfort and ability to do certain tasks. In total, 44 drivers of various age, gender, and driving experience performed three different tasks while being driven on shaker-rig (reading and writing, drawing, and subjective grading). The examination results show that FAS with road preview control offers highest ride comfort improvement, which can be perceived by the driver and greatly improves his/her ability to text and particularly draw.
Development of software component for module of lengthy objects shooting for sawn timber scanner (2018)

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Optimal Design of Filament Winding Using Neural Network Experimental Design Scheme (1999)

The goal of this paper is to design the filament winding in composites materials based on our previous developed technique. The most significant parameters in design and construction of composites prepared by filament winding are resin temperature, fiber tension and winding angle. The three variables depict nonlinear relationship; thus a nonlinear modeling technique is required. The proposed methodology enjoys many of the advantages claimed for the artificial neural network (ANN), random search optimization, fuzzy classification and information theory for the sequential design filament winding. The neural network is used to construct a model based on the currently available experimental data. Random search generates a number of candidates of the next batch of experiments. Fuzzy classification and information analysis are defined to balance the need of better classification and the relevance of each class in optimization. The test results of the proposed method show that the abilities of the proposed methodology handle multivariable experimental design and also help experimenters discuss complex trade-offs between practical limitation and statistical preferences in the experiment.
Evidence for label-retaining tumour-initiating cells in human glioblastoma (2011)

Individual tumour cells display diverse functional behaviours in terms of proliferation rate, cell-cell interactions, metastatic potential and sensitivity to therapy. Moreover, sequencing studies have demonstrated surprising levels of genetic diversity between individual patient tumours of the same type. Tumour heterogeneity presents a significant therapeutic challenge as diverse cell types within a tumour can respond differently to therapies, and inter-patient heterogeneity may prevent the development of general treatments for cancer. One strategy that may help overcome tumour heterogeneity is the identification of tumour sub-populations that drive specific disease pathologies for the development of therapies targeting these clinically relevant sub-populations. Here, we have identified a dye-retaining brain tumour population that displays all the hallmarks of a tumour-initiating sub-population. Using a limiting dilution transplantation assay in immunocompromised mice, label-retaining brain tumour cells display elevated tumour-initiation properties relative to the bulk population. Importantly, tumours generated from these label-retaining cells exhibit all the pathological features of the primary disease. Together, these findings confirm dye-retaining brain tumour cells exhibit tumour-initiation ability and are therefore viable targets for the development of therapeutics targeting this sub-population.
JTE concept evaluation and failure analysis: OBIC measurements on 4H SiC p/sup +/-n diodes (2002)

The optical beam induced current (OBIC) technique allows direct imaging of high voltage p-n junctions at a microscopic level under reverse operating conditions by measuring the local variation of the photocurrent. In this paper, we focus on demonstrating two essentially different applications of the OBIC technique: individual failure analysis and evaluation of device concepts by direct verification of the operation of the junction termination extension (JTE) as compared to simulation results.
Mechanism of the formation of microphase separated water clusters in a water-mediated physical network of perfluoropolyether tetraol (2018)

Perfluoropolyether tetraol (PFPE tetraol) possesses a hydrophobic perfluoropolyether chain in the backbone and two hydroxyl groups at each chain terminal, which facilitates the formation of hydrogen bonds with water molecules resulting in the formation an extended physical network. About 3 wt% water was required for the formation of the microphase separated physical network of PFPE tetraol. The mechanism responsible for the microphase separation of water clusters in the physical network was studied using a combination of techniques such as NMR spectroscopy, molecular dynamics (MD) simulations and DSC. MD simulation studies provided evidence for the formation of clusters in the PFPE tetraol physical network and the size of these clusters increased gradually with an increase in the extent of hydration. Both MD simulations and NMR spectroscopy studies revealed that these clusters position themselves away from the hydrophobic backbone or vice versa. The presence of intra- and inter-chain aggregation possibility among hydrophilic groups was evident. DSC results demonstrated the presence of tightly and loosely bound water molecules to the terminal hydroxyl groups of PFPE tetraol through hydrogen bonding. The data from all the three techniques established the formation of a physical network driven by hydrogen bonding between the hydrophilic end groups of PFPE tetraol and water molecules. The flexible nature of the PFPE tetraol backbone and its low solubility parameter favour clustering of water molecules at the terminal groups and result in the formation of a gel.
A phase II study of clinical activity of SCH 717454 (robatumumab) in patients with relapsed osteosarcoma and Ewing sarcoma (2016)

These findings show that although the IGF-1R remains an attractive treatment target, additional research is needed to identify responders and/or means to achieve durable remissions in order to successfully exploit IGF-1R signal blockade in Ewing sarcoma (clinicaltrials.gov: NCT00617890).