gebhart/patrepeval huggingface dataset:
Sparse Doppler Sensing Based on Nested Arrays (2018)

Spectral Doppler ultrasound imaging allows visualizing blood flow by estimating its velocity distribution over time. Duplex ultrasound is a modality in which an ultrasound system is used for displaying simultaneously both B-mode images and spectral Doppler data. In B-mode imaging, short wideband pulses are used to achieve sufficient spatial image resolution. In contrast, for Doppler imaging, narrowband pulses are preferred in order to attain increased spectral resolution. Thus, the acquisition time must be shared between the two sequences. In this work, we propose a nonuniform slow-time transmission scheme for spectral Doppler, based on nested arrays, which reduces the number of pulses needed for accurate spectrum recovery. We derive the minimal number of Doppler emissions needed, using this approach, for perfect reconstruction of the blood spectrum in a noise-free environment. Next, we provide two spectrum recovery techniques which achieve this minimal number. The first method performs efficient recovery based on the fast Fourier transform. The second allows for continuous recovery of the Doppler frequencies, thus avoiding off-grid error leakage, at the expense of increased complexity. The performance of the techniques is evaluated using realistic Field II simulations as well as in vivo measurements, producing accurate spectrograms of the blood velocities using a significantly reduced number of transmissions. The time gained, where no Doppler pulses are sent, can be used to enable the display of both blood velocities and high quality B-mode images at a high frame rate.
Adjustable speed drives transportation industry needs part II: R&amp;D and aeropropulsion (2003)

Adjustable speed drives for applications in the transportation industry are significantly different and face economic and cost pressures exceeding those of other industries. This and a companion paper constitute a summary of the present status of adjustable speed drives in the automotive, utility, and aerospace industries, including relevant topics of research and development. Specific topics in part I include the application of ASD's in hybrid electric vehicles and advanced technology vehicles that rely on x-by-wire technologies plus grid connected hybrids. In part II special treatment is given to hybrid vehicle R&D needs and aerospace propulsion needs. Particular emphasis has been given to automotive industry needs, specifically those related to environmental and performance, and how these constraints impact installation costs.
Virtual Screening for Bioactive Molecules by Evolutionary De Novo Design Special thanks to Neil R. Taylor for his help in preparation of the manuscript. (2000)

Potent K+-channel blocking agents were generated de novo using a novel computer-based evolutionary design strategy (TOPAS). The method is based on an adaptive optimization process in virtual chemical space. The picture shows the structural formula of a template and assignment of generalized atom types on the molecular framework as a two-dimensional representation.
Integrated microfluidic lab-on-a-chip systems for 18F radiotracer synthesis, purification and quality control (2015)

Objectives Dose-on-demand radiotracer production, whereby a single dose is generated using a compact synthesis unit with radioisotope from a mini-cyclotron or external supply is an interesting prospect for widening the availabilty of radiotracers. We aim to produce modules for lab-on-a-chip device design that can be used for isotope processing, synthesis and some routine quality control tests on a microfluidic scale.Methods Modules for electrode trapping and release of [18F]fluoride, synthesis of [18F]FDG and purification were produced as prototypes using bespoke manufactured microfluidic glass chips with etched channels. Monolithic separation columns were made of a suitable size from silica and the functionality by chemical modification for the different purification and separation applications.Synthesis to validate the [18F]fluoride feed was carried out in a heated capillary loop. Spectroscopic quality control tests were developed using a simple on-chip absorbance-based system for performing QC tests rapidly (few min) with small volumes (80%). V-shaped plots were used to validate pH using absoprtion spectroscopy and solvent impurity using raman spectroscopy.Conclusions Modules have been designed and tested for the synthesis of [18F]FDG. An efficient process for transfer of the [18F]fluoride into acetonitrile via electrode trapping allows synthesis of the [18F]FDG with high efficiency at low volumes was validated. Spearation modules using small (1-2 cm length) bespoke mopnolithic silica columns were used in the separations and some of the quality control tests were shown to be effective using both real samples and standards.
Discriminative training for large vocabulary telephone-based name recognition (2002)

This paper describes progress on a commercial application of the MECS recognition system to the task of recognizing Japanese family names spoken by customers into the answering machines of a large marketing/human resource company. The task is thus speaker-independent, open vocabulary, and is characterized by large variation in caller speaking styles, telephone types and acoustic environments. Our results show that context-independent hidden Markov models trained discriminatively with the minimum classification error criterion are a practical alternative to context-dependent models based on phonetic decision trees, yielding better performance with a much smaller number of parameters. On this difficult task we have obtained 59% correct family name recognition. A phoneme-based confidence measure enables us to obtain 85% correct name recognition for accepted utterances, at an overall utterance acceptance rate of 15%.
Optimal pupil screen design for the estimation of partially coherent images (1987)

The effectiveness of optical preprocessing is examined for image-estimation applications. The problem is to design the pupil of the imaging system so that the detected image is the minimum-mean-square-error estimate of the desired image. The designs of several optimal pupil screens are presented. These designs demonstrate that both the optimum pupil screen and the effectiveness of optical preprocessing are functions of the statistics of the signal and the noise and of the coherence of the object illumination. The results indicate that preprocessing is more effective for coherent systems than for incoherent systems.
Anticipating concerns of the adult learner: accelerated path to a degree and intrusive advising (2015)

The demographics of 21st century, community college students are changing. Success strategies are being developed with adult learners in mind, particularly for programs targeting students already in the workforce. While recognizing that such students may have been out of college for an extended time or have obligations differing from traditional college students, such as family and work commitments, programs designed for adult learners should provide clearly articulated pathways to success. Elements of this success strategy should provide instruction in a way that accommodates work schedules and prepares students for classroom challenges.Degree programs should be designed to help students complete coursework quickly and provide greater access to educational opportunities. Gillette College’s accelerated Mining Technology Program combines a no-options pathway to completion. It is a course delivery system allowing students who otherwise might not have the opportunity to attend college the ability to earn a degree in their career field. To further increase student success, the program relies on strategic and intrusive advising to energize students who may not be used to academic demands.
Validation of a novel diabetic retinopathy utility index using discrete choice experiments (2019)

The DRU-I can estimate utilities associated with vision-threatening DR and associated vision impairment. It has the potential to assess the cost-effectiveness of DR interventions from a patient perspective and inform policies on resource allocation relating to DR.
4th Basic Multidisciplinary Hemodialysis Access Course (2002)

The clinical examination is always the first necessary step to draw an operating indication. Conditions of the ExaminationThis must be carried out in good conditions, on a patient feeling safe and in a warm room.Fear and cold have vasoconstrictor effects.One should not hesitate to carry this examination out again before the operation, when the patient is in a warm bed, or a bit later, when a brachial plexus block has induced a significant vasodilatation.The upper limbs are undressed to the shoulders.If the patient is cold, the hand and forearm can be plunged into a washbasin of warm water, which will induce a quick vasodilatation.The presence of subcutaneous oedema or haematoma requires another later examination in better conditions.
Proteolytic activation of heparin‐binding EGF‐like growth factor by membrane‐type matrix metalloproteinase‐1 in ovarian carcinoma cells (2010)

Increased expression of heparin-binding EGF-like growth factor (HB-EGF) and membrane-type matrix metalloproteinase-1 (MT1-MMP) is frequently associated with various types of malignant tumor. HB EGF-like growth factor has been reported to promote the malignant progression of ovarian carcinoma. Based on this finding, inhibition of HB-EGF activity with CRM197 is now under phase I clinical evaluation. On the other hand, MT1-MMP expressed in ovarian carcinoma cells is thought to promote invasion and growth of tumor cells by degrading the extracellular matrix. However, we recently demonstrated that co-expression of MT1-MMP and HB-EGF in gastric carcinoma cells leads to cleavage of HB-EGF within its N-terminal heparin-binding region, converting it into a potent heparin-independent growth factor. In this study, we evaluated the importance of regulation of HB-EGF by MT1-MMP in clinical samples of ovarian carcinoma. We detected co-expression of HB-EGF and MT1-MMP in clear cell ovarian carcinoma tissues, particularly at the invasion front and in tumor cells that had disseminated into the ascites, whereas HB-EGF alone was expressed in non-invasive borderline ovarian tumor tissue. Furthermore, a soluble HB-EGF fragment that corresponds to that processed by MT1-MMP was detected in malignant ascites obtained from patients with metastatic ovarian carcinoma. Ovarian carcinoma cells that express MT1-MMP and HB-EGF exhibited enhanced cell growth in a 3D-collagen matrix and anchorage-independent growth in suspension. These results indicate that MT1-MMP co-expressed with HB-EGF in ovarian carcinoma cells potentiates the activity of HB-EGF to promote invasive tumor growth and spreading in vivo.
Thresholding Graph Bandits with GrAPL (2019)

In this paper, we introduce a new online decision making paradigm that we call Thresholding Graph Bandits. The main goal is to efficiently identify a subset of arms in a multi-armed bandit problem whose means are above a specified threshold. While traditionally in such problems, the arms are assumed to be independent, in our paradigm we further suppose that we have access to the similarity between the arms in the form of a graph, allowing us gain information about the arm means in fewer samples. Such settings play a key role in a wide range of modern decision making problems where rapid decisions need to be made in spite of the large number of options available at each time. We present GrAPL, a novel algorithm for the thresholding graph bandit problem. We demonstrate theoretically that this algorithm is effective in taking advantage of the graph structure when available and the reward function homophily (that strongly connected arms have similar rewards) when favorable. We confirm these theoretical findings via experiments on both synthetic and real data.
PAM-4 Signaling over VCSELs with 0.13µm CMOS Chip Technology (2006)

We present results for VCSEL based links operating PAM-4 signaling using a commercial 0.13microm CMOS technology. We perform a complete link analysis of the Bit Error Rate, Q factor, random and deterministic jitter by measuring waterfall curves versus margins in time and amplitude. We demonstrate that VCSEL based PAM-4 can match or even improve performance over binary signaling under conditions of a bandwidth limited, 100meter multi-mode optical link at 5Gbps. We present the first sensitivity measurements for optical PAM-4 and compare it with binary signaling. Measured benefits are reconciled with information theory predictions.
Lehigh Instrument for Learning Interaction (LILI): An Interactive Robot to Aid Development of Social Skills for Autistic Children (2014)

Recent studies show that autistic children tend to speak and interact more in the presence of an interactive robot. Unfortunately, most of the robotic experiments were conducted in highly controlled clinical settings or limited selected home environments due to the high deployment cost. In this paper, we design a low-cost interactive robot that can be readily deployed to home environments. Our robot, called Lehigh Instrument for Learning Interaction (LILI), interacts with users via gestures, voice commands, and an animated speaking avatar. LILI can recognize users' faces, and her motion can be controlled either via gesture or voice. We describe both the system and software architectures of LILI. Experimental results are also presented.
A Simple Negative Bias Temperature Instability Characterization Methodology to Minimize the Immediate Recovery Effect during Measurement (2006)

Negative bias temperature instability (NBTI) degradation of p-channel metal–oxide–semiconductor field effect transistors ( p-MOSFETs) is significantly underestimated by using the conventional characterization techniques due to a severe NBTI recovery during the measurements. In this work, a simple characterization method based on the single-point measurement of the saturated drain current is proposed to minimize the unwanted recovery effect. This method is accurate as is proven by a carefully-designed experiment. With this new proposed method, the measurement time is reduced to tens of milliseconds. This method gives a closer-to-real threshold voltage shift, and yields a more reliable power-law factor and thus a more realistic NBTI picture.
Proton gated emission from porous silicon (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProton gated emission from porous siliconJonathan K. M. Chun, Andrew B. Bocarsly, Timothy R. Cottrell, Jay B. Benziger, and Jason C. YeeCite this: J. Am. Chem. Soc. 1993, 115, 7, 3024–3025Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April 1993https://pubs.acs.org/doi/10.1021/ja00060a080https://doi.org/10.1021/ja00060a080research-articleACS PublicationsRequest reuse permissionsArticle Views180Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Induction of apoptosis by pectenotoxin-2 is mediated with the induction of DR4/DR5, Egr-1 and NAG-1, activation of caspases and modulation of the Bcl-2 family in p53-deficient Hep3B hepatocellular carcinoma cells (2008)

The tumor suppressor protein p53 restricts proliferation in response to DNA damage or the deregulation of mitogenic oncogenes, by leading to the induction of various cell cycle checkpoints, apoptosis or cellular senescence. Consequently, p53 mutations increase cell proliferation and survival and in some settings promote genomic instability and resistance to certain anti-cancer drugs. It is very important to identify chemotherapeutic agents that activate in a p53-independent manner for the development of treatments for p53-deficient tumors. Pectenotoxin-2 (PTX-2), isolated from marine sponges has been reported to display significant cytotoxicity to p53-deficient cancer cell lines. In this study, we compared the anti-cancer activity of PTX-2 in order to further test the status of p53 using two well-known hepatocarcinoma cell lines, p53-deficient Hep3B and p53-wild-type HepG2. MTT assay indicated that Hep3B cells were highly susceptible, whereas HepG2 cells were more resistant to this compound which was connected with the induction of apoptotic cell death in p53-deficient Hep3B cells, though not in HepG2 cells. The apoptosis induced by PTX-2 in Hep3B cells was associated with the down-regulation of anti-apoptotic Bcl-2 members (Bcl-2 and Bcl-xL) and IAP family proteins, the up-regulation of pro-apoptotic Bax protein and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-receptor 1/receptor 2 (DR4/DR5) and mitochondrial dysfunction. PTX-2 activated caspases (caspase-3, -8 and -9) and the blockade of caspase-3 activity by the caspase-3 inhibitor prevented the PTX-2-induced apoptosis in Hep3B cells. Additionally, the transcription factor early growth response-1 (Egr-1) gene was transcriptionally activated and the levels of non-steroidal anti-inflammatory drugs (NSAID)-activated gene-1 (NAG-1) protein were also elevated in PTX-2-treated Hep3B cells. Although further studies are needed to prove that an increased expression of Egr-1 by PTX-2 directly leads to NAG-1 induction and then apoptosis induction in p53-deficient Hep3B cells, the results of this study suggest that PTX-2 may be a good candidate for the development of a potential anti-tumorigenic agent in p53-deficient tumors.
Three Novel Class 1 Integrons Detected in Multidrug-Resistant Pseudomonas aeruginosa Hospital Strains (2019)

The antibacterial resistance of healthcare-associated infection (HAI) agents is a major public health problem worldwide. Pseudomonas aeruginosa is one of the main HAI agents, especially in intensive care units (ICUs). The present study focuses on the identification of antibacterial resistance genetic determinants and on determining the structure of mobile genetic elements—novel class 1 integrons of P. aeruginosa. P. aeruginosa strains (n = 105) were collected in the Department of the Moscow Neurosurgery ICU in 2013–2016 from the respiratory system (60.0%), urine (28.6%), surgical wounds (5.7%), blood (2.9%), and cerebrospinal fluid (2.9%). The majority (92.4%) of strains were characterized by a phenotype of multidrug-resistance. Beta-lactamase genes blaVIM-2-like, which are widely distributed in Russia, were identified in 37.7% of strains. The blaCTX-M-15 gene was carried by 3.0% of strains that is the first report of such gene identification in P. aeruginosa in Russia. Class 1 integrons were detected in 63.0% of strains, with 36.7% of strains carrying seven types of gene cassette arrays: (blaVIM-2-like), (aadA6-gcuD), (aacA7-blaVIM-2-like), (aac(3 ')Ic-cmlA5), (aadA6Δ3::ISPa21e-gcuD), (gcu87-aadB-aphA15d-aadA1a), and (blaPBL-1-aacA4). The latter three gene cassette arrays are new for class 1 integrons. Identification numbers have been assigned to novel integrons: In1379, In1360, and In1375. New genetic structures were described: the aadA6 gene cassette with inserted ISPa21уe element (In1379); the gsu87 gene cassette coding hypothetical protein which is not represented in the GenBank database (In1360); novel allele of aphA15d gene cassette and the blaPBL-1 gene cassette coding new, not previously described, beta-lactamase of class A (In1375). Identification of novel genetic structures of antibacterial resistance in P. aeruginosa strains isolated in the course of 3 years indicates the activity of genetic processes associated with antibiotic resistance in hospital pathogens in the Department of Neuro-ICU, which indicates the activity of genetic processes associated with the formation of multiple drug resistance of hospital pathogens.
Improvement of die life with surface texture control and solid lubricant (2012)

Abstract The methodology of controlling the surface texture of dies by means of Hybrid-shot peening was examined for the improvement of the die life cycle applied to high strength steel sheets. Hybrid-shot is double-shot peening, where the first treatment is performed using large particles, and the second one is performed with finer shot particles. The specimens of tool steels for dies treated by Hybrid-shot showed a high resistance against galling which was evaluated by the galling generation load of the draw bead test by using an oil lubricant, compared with the single shot specimens. This result suggested that the surface texture influenced the galling property. For a quantitative analysis of surface texture of die material, Fast Fourier Transformation (FFT) was used. Findings revealed that the ratio of the spectrum amplitude between high and low frequencies calculated by FFT corresponded to the galling generation load of draw bead tests. On the other hand, the conventional index of surface roughness, Rz, had no relationship to the galling generation load. Furthermore, the effect of solid lubricant, that is, the powder produced by scallop shell, on the galling property was studied. The addition of fine scallop shell powder in the oil lubricant increased the galling generation load.
Requirement for the acetyl phosphate pathway in Escherichia coli ATP‐dependent proteolysis (2006)

Protein degradation is a central component of the protein quality control system. Here we show that efficient proteolysis in Escherichia coli requires the active acetyl phosphate pathway. Deletion of this pathway, leading to depletion of acetyl phosphate, results in temperature sensitivity and reduced rate of ATP-dependent proteolysis. The effect on proteolysis is general, as can be seen from the slowing down of the degradation of unstable proteins, including puromycin-derived peptides. In addition, reduced intracellular concentrations of acetyl phosphate brings about an increase in the levels of protein aggregates, which contain a wide range of proteins, as expected if a broad spectrum of substrates are involved. Additional outcomes of acetyl phosphate deficiency are elevation in the transcript levels of heat shock genes and increased thermotolerance. In E. coli the acetyl phosphate pathway is the only source of acetyl phosphate, which is a key metabolic compound involved in major cellular processes. In this communication we present evidence for the general role of the acetyl phosphate pathway in protein degradation.
Periodic Mesoporous Organosilica with Large Cagelike Pores (2002)

Ordered mesoporous organosilica with large (10 nm) cagelike pores was synthesized using a triblock copolymer template and characterized using 29Si and 13C NMR spectroscopy, nitrogen adsorption, thermogravimetry, TEM, and SAXS.