gebhart/patrepeval huggingface dataset:
Le syndrome de régression psycho-motrice du vieillard (1986)

Background US contrast agents are gas-filled microbubbles (MBs) that can be locally destroyed by using external US. Among other bioeffects, US-triggered MB destruction, also known as UTMD, has been shown to sensitize solid tumors to radiation in preclinical models through localized insult to the vascular endothelial cells. Purpose To evaluate the safety and preliminary efficacy of combining US-triggered MB destruction and transarterial radioembolization (TARE) in participants with hepatocellular carcinoma (HCC). Materials and Methods In this pilot clinical trial, participants with HCC scheduled for sublobar TARE were randomized to undergo either TARE or TARE with US-triggered MB destruction 1-4 hours and approximately 1 and 2 weeks after TARE. Enrollment took place between July 2017 and February 2020. Safety of US-triggered MB destruction was evaluated by physiologic monitoring, changes in liver function tests, adverse events, and radiopharmaceutical distribution. Treatment efficacy was evaluated by using modified Response Evaluation Criteria in Solid Tumors (mRECIST) on cross-sectional images, time to required next treatment, transplant rates, and overall survival. Differences across mRECIST reads were compared by using a Mann-Whitney <i>U</i> test, and the difference in prevalence of tumor response was evaluated by Fisher exact test, whereas differences in time to required next treatment and overall survival curves were compared by using a log-rank (Mantel-Cox) test. Results Safety results from 28 participants (mean age, 70 years ± 10 [standard deviation]; 17 men) demonstrated no significant changes in temperature (<i>P</i> = .31), heart rate (<i>P</i> = .92), diastolic pressure (<i>P</i> = .31), or systolic pressure (<i>P</i> = .06) before and after US-triggered MB destruction. No changes in liver function tests between treatment arms were observed 1 month after TARE (<i>P</i> > .15). Preliminary efficacy results showed a greater prevalence of tumor response (14 of 15 [93%; 95% CI: 68, 100] vs five of 10 [50%; 95% CI: 19, 81]; <i>P</i> = .02) in participants who underwent both US-triggered MB destruction and TARE (<i>P</i> = .02). Conclusion The combination of US-triggered microbubble destruction and transarterial radioembolization is feasible with an excellent safety profile in this patient population and appears to result in improved hepatocellular carcinoma treatment response. © RSNA, 2020.
Polymorphisms in the lcrV Gene of Yersinia enterocolitica and Their Effect on Plague Protective Immunity (2012)

Current efforts to develop plague vaccines focus on LcrV, a polypeptide that resides at the tip of type III secretion needles. LcrV-specific antibodies block Yersinia pestis type III injection of Yop effectors into host immune cells, thereby enabling phagocytes to kill the invading pathogen. Earlier work reported that antibodies against Y. pestis LcrV cannot block type III injection by Yersinia enterocolitica strains and suggested that lcrV polymorphisms may provide for escape from LcrV-mediated plague immunity. We show here that polyclonal or monoclonal antibodies raised against Y. pestis KIM D27 LcrV (LcrV(D27)) bind LcrV from Y. enterocolitica O:9 strain W22703 (LcrV(W22703)) or O:8 strain WA-314 (LcrV(WA-314)) but are otherwise unable to block type III injection by Y. enterocolitica strains. Replacing the lcrV gene on the pCD1 virulence plasmid of Y. pestis KIM D27 with either lcrV(W22703) or lcrV(WA-314) does not affect the ability of plague bacteria to secrete proteins via the type III pathway, to inject Yops into macrophages, or to cause lethal plague infections in mice. LcrV(D27)-specific antibodies blocked type III injection by Y. pestis expressing lcrV(W22703) or lcrV(WA-314) and protected mice against intravenous lethal plague challenge with these strains. Thus, although antibodies raised against LcrV(D27) are unable to block the type III injection of Y. enterocolitica strains, expression of lcrV(W22703) or lcrV(WA-314) in Y. pestis did not allow these strains to escape LcrV-mediated plague protective immunity in the intravenous challenge model.
Viewing versus Experiencing in Adopting Somatosensory Technology for Smart Applications (2014)

Emerging somatosensory technology offers unprecedented opportunities for researchers and industrial practitioners to design a touchless smart home system. However, existing touchless smart home systems often fail to attract a satisfying level of acceptance among home owners. The experience users have with the touchless system is key to making somatosensory technology a pervasive computing home application, yet little research has been conducted to assess the influence of direct and indirect experience on user’s behavioral intention to use somatosensory technology. To address this research gap, this paper set up an experimental design to investigate the influence of direct and indirect experience in user technology acceptance. Using an in-house developed touchless system, two experimental studies (i.e., video observation versus product trial) were conducted with sixty-two participants to investigate whether the user experience has an impact on the adoption decision. Our findings indicate that direct experience has an impact on a user’s acceptance of somatosensory technology. We found a significant difference in the relationships between perceived complexity and usage intentions. Perceived complexity was a significant predictor of an individual’s behavioral intention to use the touchless system after video observation, while its relationship to usage intention was insignificant after the user had direct experience with touchless system. Our study reveals an important implication for somatosensory technology marketers, in which product trial (direct experience) engenders more reliable inferences than does exposure to video demonstration (indirect experience). Based on this, companies should devise marketing programme involving direct experience (e.g., product trial and showroom visit) to promote new somatosensory-enabled smart home systems. The results of the study also demonstrate that user experience in research design may influence the results of the Technology Acceptance Model (TAM) studies. Available at: https://aisel.aisnet.org/pajais/vol6/iss3/2/
5-GHz-Band Vehicle-to-Vehicle Channels: Models for Multiple Values of Channel Bandwidth (2010)

In Sen and Matolak's earlier paper, 5-GHz-band vehicle-to-vehicle (V2V) channel models were presented for channel bandwidths of 5 and 10 MHz. In this paper, we provide additional tapped delay line models for bandwidths of 1, 20, 33.33, and 50 MHz based upon the data used in Sen and Matolak's paper. We provide tables of channel parameters for five types of V2V channel classes and also include example tap correlation coefficients. Root-mean-square delay spread values are summarized, as are values of bandwidth for which the channel frequency correlation takes values of 0.7 and 0.5. As with the results from Sen and Matolak's paper, these models should be useful for designers in future V2V communication systems.
Complexes between photoactivated rhodopsin and transducin: progress and questions (2010)

Activation of GPCRs (G-protein-coupled receptors) leads to conformational changes that ultimately initiate signal transduction. Activated GPCRs transiently combine with and activate heterotrimeric G-proteins resulting in GTP replacement of GDP on the G-protein alpha subunit. Both the detailed structural changes essential for productive GDP/GTP exchange on the G-protein alpha subunit and the structure of the GPCR-G-protein complex itself have yet to be elucidated. Nevertheless, transient GPCR-G-protein complexes can be trapped by nucleotide depletion, yielding an empty-nucleotide G-protein-GPCR complex that can be isolated. Whereas early biochemical studies indicated formation of a complex between G-protein and activated receptor only, more recent results suggest that G-protein can bind to pre-activated states of receptor or even couple transiently to non-activated receptor to facilitate rapid responses to stimuli. Efficient and reproducible formation of physiologically relevant, conformationally homogenous GPCR-G-protein complexes is a prerequisite for structural studies designed to address these possibilities.
Affinitätssensor auf der Grundlage eines Membranosmometers (Affinity Sensor based on a Membrane Osmometer) (2004)

Abstract Beim osmotischen Affinitätssensor wird die Konzentration von niedermolekularen Analytmolekülen gemessen, die einen polymeren Affinitätsliganden aus einem Komplex mit einem Affinitätsrezeptor verdrängen können. Der Ligandenaustausch findet in einem Mikro-Membran-Osmometer statt und führt zu einer Konzentrationsänderung der Polymere in der Osmometerzelle. Somit bewirkt der Ligandenaustausch eine Änderung der hydrostatischen Druckdifferenz gegenüber der Außenlösung. Da der Austausch von Dextranmolekülen an dem Lektin Concanavalin A durch Glucose relativ schnell und reversibel erfolgt, kann die Glucosekonzentration mit einem osmotischen Affinitätssensor kontinuierlich gemessen werden.
Electrochemical Study of Functional Additives for Li-Ion Batteries (2020)

In the battery industry, the performance of lithium-ion batteries operating at a high voltage is enhanced by utilizing functional additives in electrolytes to achieve higher energy densities and longer lifetimes. These additives chemically stabilize the electrolyte and aid in the formation of a stable cathode electrolyte interphase (CEI). In this paper, the investigation of oxidative potentials of more than 100 additives, using density functional theory calculations to determine the best candidates for CEI formation, is reported. The method was validated by comparing the calculated oxidation potentials and the experimental data obtained using linear sweep voltammetry based on the evaluation of 18 candidates. Further electrochemical studies (AC impedance and cycling stability) on six selected additives were conducted. Among the tested additives, the addition of quinacridone at 0.03% weight concentration resulted in the formation of a less resistive surface film on the cathode in Li/Ni 0.5 Mn 0.3 Co 0.2 O 2 coin cells. Moreover, the capacity retention in Gr/Ni 0.5 Mn 0.3 Co 0.2 O coin cells increased from 62% to 77% after 200 cycles at 1C and approximately 4.4 V. The derived results suggest that the combination of the oxidation potential prediction with impedance study could be used as a powerful tool to properly and efficiently select CEI-forming additive candidates for improved battery performance.
SU-E-T-719: Multi-Energetic, GPU-Accelerated Superposition/Convolution (2011)

Purpose: To develop a novel superposition/convolution based algorithm which eliminates the poly-energetic transport approximation. Methods: We leveraged the hardware functionality of the GPU texture unit to allow our modern dual-source superposition/convolution based dose calculation engine to efficiently perform multiple transports simultaneously. We experimented with dividing the spectrum in half (dual-energetic), quarters (quad-energetic) or N energy bins (multi-energetic). These divisions were applied after the TERMA was computed using the exact, full-spectrum attenuation. We have benchmarked the dosimetric properties of poly-, dual-, quad- and multi-energetic superposition against a series of Monte Carlo dose accuracy benchmarks based on the ICCR 2000 benchmark and have performed a manual commissioning for an Elekta Infinity operating at 6MV. Results: The performance cost of dual-energetic superposition was 11%–50%. The performance cost of quad-energetic superposition was 39%–151%. Performance varied depending on GPU architecture and cache effects. The slower performance of quad-energetic superposition was due to a smaller CUDA block size and the use of a separate density texture: we normally pack TERMA and density into a single texture. TERMA performance costs were 1% and 10%, respectively. The traditional, poly-energetic superposition overestimated dose, particularly within the first 10 cm and in bone/aluminum. Dual-energetic superposition greatly reduced this overestimation. Quad-energetic and multi-energetic superposition produced nearly identical results. Good agreement was achieved in air, water, bone and aluminum; all methods had trouble matching the fall off in lung due to the small treatment field. We based our manual commissioning of our Elekta Infinity linear accelerator on a published spectrum. We modeled the extra-focal source as being very soft, which necessitated a slight hardening of the primary source. Conclusions: We have completed a multi-energetic, GPU-accelerated superposition/convolution based algorithm, which improves accuracy over the traditional, poly-energetic approach and allows the use of physically accurate spectrums.
Laser flash photolysis of chlorine dioxide: formation and ultraviolet absorption spectrum of chlorine oxide (Cl_2O_3) (1989)

The kinetics of ClO_2 photodecomposition in trichlorofluoromethane solutions induced by 337.1-nm pulses were investigated under various experimental conditions. Instantaneous photochemical bleaching is followed by a slower bleaching which follows pseudo-first-order kinetics and leads to the formation of a long-lived transient species absorbing up to 330 nm with λ_(max) ~ 280 nm. At high concentrations of ClO_2 identical amounts of chlorine dioxide are consumed in both stages, revealing that the latter involves stoichiometric reaction of an initially formed intermediate with excess ClO_2 Addition of tetramethylethylene, a very efficient oxygen atom quencher, had no detectable effect on the kinetics of ClO_2 decay. The intermediate is therefore identified as ClO and the new species as Cl_2O_3, chlorine sesquioxide, formed by reaction 5: ClO + ClO_2 → Cl_2O_3.
IS-IS Extension to Support Segment Routing over IPv6 Dataplane (2020)

Segment Routing (SR) allows for a flexible definition of end-to-end
paths by encoding paths as sequences of topological sub-paths, called
segments. Segment routing architecture can be implemented over an
MPLS data plane as well as an IPv6 data plane. This draft describes
the IS-IS extensions required to support Segment Routing over an IPv6
data plane.
Mcl-1 blocks radiation-induced apoptosis and inhibits clonogenic cell death. (2005)

Mcl-1 expression affects the radioresistance of human melanoma cells.
Fast neuromorphic sound localization for binaural hearing aids (2013)

We report on the neuromorphic sound localization circuit which can enhance the perceptual sensation in a hearing aid system. All elements are simple leaky integrate-and-fire neuron circuits with different parameters optimized to suppress the impacts of synaptic circuit noises. The detection range and resolution of the proposed neuromorphic circuit are 500 us and 5 us, respectively. Our results show that, the proposed technique can localize a sound pulse with extremely narrow duration (∼ 1 ms) resulting in real-time response.
Demonstration of Quadrature-Squeezed Surface Plasmons in a Gold Waveguide (2009)

We report on the efficient generation, propagation, and reemission of squeezed long-range surface-plasmon polaritons in a gold waveguide. Squeezed light is used to excite the nonclassical surface-plasmon polaritons, and the reemitted quantum state is fully characterized by complete quantum tomographic reconstruction of the density matrix. We find that the plasmon-assisted transmission of nonclassical light in metallic waveguides can be described by a beam splitter relation. This result is explained theoretically.
Privacy protection for personal data integration and sharing in care coordination services: A case study on wellness cloud (2012)

Care coordination services bring together a multitude of providers to deliver continuity of care outside clinical settings. The coordinated services improve wellness management and operational outcomes but pose challenges on privacy when integrating multiple sources of personal health data and providing a data access and sharing mechanism to third party providers. In this paper, we particularly address the privacy challenges associated with data integration and sharing in a multi-tenant cloud environment for healthcare. We present three care coordination use cases and detail the functional requirements across different stages of a personal data service cycle. Additionally, reflecting on technical challenges associated with privacy-preserving data integration and sharing, we introduce a set of common data services to handle these issues, which ultimately lend support to the development of accountable coordinated care services.
640Gbit/s Reconfigurable OTDM Add-Drop Multiplexer (2011)

A 640Gbit/s reconfigurable OTDM add/drop multiplexer is demonstrated, using a single periodically-poled Lithium-Niobate waveguide in a counter-propagating configuration. Error free operations confirm the effectiveness of a single device for simultaneous add/drop operations.
Purification and characterization of an extracellular muramidase of Clostridium acetobutylicum ATCC 824 that acts on non-N-acetylated peptidoglycan (1992)

An extracellular enzyme showing lytic activity on non-N-acetylated peptidoglycan has been isolated from Clostridium acetobutylicum ATCC 824. The lytic enzyme was purified to homogeneity by anion-exchange chromatography and gel filtration, with a recovery of 24%. The enzyme was monomeric and had an estimated molecular weight of 41,000 and an isoelectric point of 3.8. It has been characterized as a muramidase whose 23-amino-acid N terminus displayed 39% homology with the N,O-diacetyl muramidase of the fungus Chalaropsis sp. The muramidase hydrolyzed purified cell walls at an optimum pH of 3, with a maximum velocity of 9.1 mumol of reducing sugars released min-1 mg of muramidase-1 and a concentration of cell walls giving a half-maximum rate of 0.01 mg ml-1. Its activity was inhibited by glucosamine, N-acetylglucosamine, Hg2+, Fe3+, and Ag+ but not by choline. The muramidase-peptidoglycan complex rapidly dissociated before total hydrolysis of the chain and randomly reassociated on another peptidoglycan chain. The affinity of the muramidase was affected by the protein content and the acetylation of the cell wall.
Methodology for motion base simulation of closed loop supermaneuvers on a centrifuge simulator (2002)

A methodology for designing a closed-loop motion simulation is discussed. This procedure is applicable to a centrifuge simulator as well as other types of devices which can produce both motion and visual fields. The key issues of coordinating the motion field with the visual simulation are discussed. Both systems are driven by the stick commands of the pilot, thus making it closed loop. The motion fields simulated are based on supermaneuvarable flight trajectories where research is needed to investigate how these supermaneuvers influence the ability of a pilot to perform a mission. It has been shown in performance studies that an agile aircraft has a definite combat edge over a nonagile aircraft. Using agility, a tactical maneuver can be performed expending less overall aircraft energy.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Mutual Coupling Suppression With Decoupling Ground for Massive MIMO Antenna Arrays (2019)

A concept of decoupling ground is introduced in this paper to enhance the isolation of massive MIMO antenna arrays. For an array, mutual coupling between array elements can be achieved by the free-space coupling and the coupling currents flowing on the ground plane shared by elements. The isolation in this paper is improved by adjusting the shape of the ground plane under each element to make the mutual coupling from the free space and the ground plane out of phase. In this way, low mutual coupling is realized. As the first example, a single-polarization linear array with eight elements is designed, simulated, and measured to verify the concept as well as the simulation accuracy. The measurements align very well with the simulations. Another two examples of dual-polarization 2×2 and 4×4 square arrays are also given and simulated to demonstrate the effectiveness of the proposed technique. In all of these examples, the isolation can efficiently be enhanced with the DG for all the co-polarization and cross-polarization coupling paths of the massive MIMO elements. Compared with the previous literature, the arrays with the DG method can achieve either much better isolation or a much lower profile while keeping the other performance comparable.
[3 + 2]-Cycloadditions of Azomethine Imines and Ynolates (2016)

A novel [3 + 2]-cycloaddition between azomethine imines and lithium ynolates is described to synthesize bicyclic pyrazolidinones. These bicyclic pyrazolidinones are versatile intermediates to form β-amino acids and monocyclic pyrazolidinones. High diastereoselectivity and stereospecificity allow access to optically active products.
Regulation of major histocompatibility complex class II expression by Pasteurella haemolytica leukotoxin (1994)

Many properties have been associated with Pasteurella haemolytica leukotoxin and other repeat-in-toxin toxins, including their cytotoxic activity on various cells of the lymphoid and nonlymphoid systems as well as their ability to modulate the immunological activity of lymphocytes and monocytes. In this study, we assessed the ability of P. haemolytica leukotoxin to affect the expression major histocompatibility complex (MHC) class II molecules on bovine peripheral monocytes. Peripheral blood mononuclear cells were isolated from P. haemolytica leukotoxin-seronegative calves and incubated with various concentrations of authentic leukotoxin as well as the recombinant lktA gene product (LktA). Expression of MHC class II antigen on cells was evaluated by flow cytometric methods. The results indicated that both a crude, authentic leukotoxin preparation and LktA were able to affect MHC class II expression by inducing a marked downregulation of MHC class II expression on bovine monocytes. However, when cells were activated with gamma interferon (IFN-gamma), LktA and Lkt had little or no detectable effect. By using a cell line which expresses MHC class II only after activation by INF-gamma, we were able to confirm the observation that LktA had no effect on the expression of MHC class II after IFN-gamma treatment. Leukotoxin affected the functional capacity of monocytes to present antigen, as demonstrated by the ability of LktA or authentic leukotoxin to totally inhibit a mixed lymphocyte culture from MHC-mismatched calves. Thus, leukotoxin was able to downregulate constitutive expression of MHC class II expression, and we propose that this is a novel way in which this molecule can affect the immune function of monocytes, playing an important role in bacterial pathogenesis and survival of organisms at the infection site.