gebhart/patrepeval huggingface dataset:
Delineation of target expression profiles in CD34+/CD38− and CD34+/CD38+ stem and progenitor cells in AML and CML (2020)

In an attempt to identify novel markers and immunological targets in leukemic stem cells (LSCs) in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML), we screened bone marrow (BM) samples from patients with AML (n = 274) or CML (n = 97) and controls (n = 288) for expression of cell membrane antigens on CD34+/CD38- and CD34+/CD38+ cells by multicolor flow cytometry. In addition, we established messenger RNA expression profiles in purified sorted CD34+/CD38- and CD34+/CD38+ cells using gene array and quantitative polymerase chain reaction. Aberrantly expressed markers were identified in all cohorts. In CML, CD34+/CD38- LSCs exhibited an almost invariable aberration profile, defined as CD25+/CD26+/CD56+/CD93+/IL-1RAP+. By contrast, in patients with AML, CD34+/CD38- cells variably expressed "aberrant" membrane antigens, including CD25 (48%), CD96 (40%), CD371 (CLL-1; 68%), and IL-1RAP (65%). With the exception of a subgroup of FLT3 internal tandem duplication-mutated patients, AML LSCs did not exhibit CD26. All other surface markers and target antigens detected on AML and/or CML LSCs, including CD33, CD44, CD47, CD52, CD105, CD114, CD117, CD133, CD135, CD184, and roundabout-4, were also found on normal BM stem cells. However, several of these surface targets, including CD25, CD33, and CD123, were expressed at higher levels on CD34+/CD38- LSCs compared with normal BM stem cells. Moreover, antibody-mediated immunological targeting through CD33 or CD52 resulted in LSC depletion in vitro and a substantially reduced LSC engraftment in NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) mice. Together, we have established surface marker and target expression profiles of AML LSCs and CML LSCs, which should facilitate LSC enrichment, diagnostic LSC phenotyping, and development of LSC-eradicating immunotherapies.
Porphyrin Synthesis in Liverwort Cells Induced by Peroxidizing Herbicides (1994)

The kinetics of protoporphyrin IX (PPIX) accumulation and of a pigment fluorescing at 590 nm (590FP) in Marchantia polymorpha L. cells were investigated after treatment with acifluorfen methyl (AFM) at various stages of cell growth in the light or dark. A correlation between accumulation of 590FP and herbicidal damage of cultured cells was observed, but not with accumulation of PPIX. - Using cells of the exponential growth phase in the light and treated with AFM, start of 590FP accumulation coincided with the decrease of PPIX after a 15-h treatment. Loss of chlorophyll in the culture correlated with the decrease of 590FP. After pre-incubation of cells with AFM for 48 h in the dark a high level of 590FP was attained, leading rapidly to peroxidizing activity in the light with a concurrent fast decrease of 590FP. Dark pre-incubation with AFM for 12 h only yielded a high level of PPIX but little peroxidation occurred as long as 590FP had not markedly accumulated. - In cells of the stationary phase, substantial PPIX levels were found when grown with AFM present in the light for two days, and then cultivated without AFM for additional 28 days. However, 590FP did not accumulate, and neither cell disruption nor inhibition of growth occurred. - The findings indicate that PPIX may be transformed to 590FP at least under the oxidative condition induced by AFM and that 590FP causes phytotoxicity in the light.
Registration of soybean cultivar ‘TN15‐5007’ with high meal protein (2020)

Abstract Soybean [ Glycine max (L.) Merr.] cultivar ‘TN15‐5007’ (Reg. no. CV‐535, PI 692131) is a conventional (non‐genetically modified) cultivar released by the Tennessee Agricultural Experiment Station in 2019 on the basis of high seed yield in Tennessee, the Mid‐South, and southeastern regions of the United States. It was developed to create a high‐yielding cultivar with high meal protein. TN15‐5007 was developed from 1 of 3,500 single plants. Progeny rows were selected using breeder's phenotypic score, which includes adapted maturity, lodging resistance, disease resistance, and pod density. TN15‐5007 was a selected line and was entered in yield tests in 2015–2018. TN15‐5007 has white flowers and gray pubescence. The plants have an upright growth habit with good resistance to lodging. The pods have a tan pod coat, and the seeds are yellow. The 100‐seed weight is approximately 12.7 g, which was equal to that of ‘Ellis’ in the 2018 USDA Uniform Test. In that test, TN15‐5007 matured 2 d earlier than Ellis, the same as ‘AG 46X7’, 1 d earlier than ‘AG 4835’, and 1 d later than ‘AG 4632’, indicating that the relative maturity of TN15‐5007 is approximately 4.7, which is highly desirable for producers in Tennessee and the Mid‐South region. TN15‐5007 is resistant to the disease stem canker. It produced 436 g kg −1 protein and 213 g kg −1 oil on a dry weight basis and produced a very high 505 g kg −1 meal protein in the 2018 Southern Uniform Test.
Adhesives, 2. Applications (2010)

Abstract The article contains sections titled: 1. Paper and Packaging Industry 1.1. Graphic Products 1.1.1. Bookbinding 1.1.1.1. Perfect Binding (Unsewn Binding) of Books 1.1.1.2. Book Manufacture 1.1.2. Fold Gluing 1.2. Adhesives for Packaging and Packaging Materials 1.2.1. Manufacture of Corrugated Board 1.2.2. Lamination of Paper and Board 1.2.3. Folder Gluer 1.2.4. Folding Cartons 1.2.5. Flexible Packages 1.2.6. Bags, Sacks, and Pouches 1.2.7. Adhesive Coating of Paper and Board 1.2.8. Adhesives for Automatic Packaging Machines 1.2.9. Reclosure Systems for Liquid Packaging Boards 1.2.10. Membrane Bonding 1.2.11. Pallet Securing 1.3. Envelopes and Advertising Mail 1.4. Cigarette Manufacture 1.5. Labeling 1.6. Nonwovens Hygiene Industry 1.7. Hygienic Tissue Papers 2. Gluing of Wood and Wooden Materials 3. Footwear Adhesives 4. Bonding of Plastics 5. Bonding of Elastomers 5.1. Postvulcanization Bonding of Rubber 5.2. Vulcanization Bonding of Rubber 6. Bonding of Metals 7. Adhesives for Wallcoverings 8. Flooring Adhesives 9. Building Construction Adhesives 10. Adhesives for Bonding Textile Fabrics 11. Flocking Adhesives 12. Adhesives for Bonding Glass 13. Adhesives in Automobile Manufacture 14. Adhesives in Aircraft Construction 15. Adhesives and Sealants in Electronics 15.1. Introduction 15.2. Conductive Adhesives 15.3. Coating and Protection Products 15.4. Surface Mounting Adhesives 15.5. Adhesives for Flat‐Panel Display Manufacture 16. Medical Adhesives 17. Household Adhesives and Do‐It‐Yourself Products 17.1. Household Adhesives 17.1.1. Adhesive Rollers (Paper Adhesives in Cassette Form) 17.2. Do‐It‐Yourself Products 18. Applications of Anaerobic Adhesives 18.1. Introduction 18.2. Main Applications Types 18.2.1. Threadlockers 18.2.2. Threadsealants 18.2.3. Chemical Gaskets 18.2.4. Retaining Compounds 18.2.5. Por
Protective antibodies against human parainfluenza virus type 3 infection (2021)

Human parainfluenza virus type III (HPIV3) is a common respiratory pathogen that afflicts children and can be fatal in vulnerable populations, including the immunocompromised. There are currently no effective vaccines or therapeutics available, resulting in tens of thousands of hospitalizations per year. In an effort to discover a protective antibody against HPIV3, we screened the B cell repertoires from peripheral blood, tonsils, and spleen from healthy children and adults. These analyses yielded five monoclonal antibodies that potently neutralized HPIV3 <i>in vitro</i>. These HPIV3-neutralizing antibodies targeted two non-overlapping epitopes of the HPIV3 F protein, with most targeting the apex. Prophylactic administration of one of these antibodies, PI3-E12, resulted in potent protection against HPIV3 infection in cotton rats. Additionally, PI3-E12 could also be used therapeutically to suppress HPIV3 in immunocompromised animals. These results demonstrate the potential clinical utility of PI3-E12 for the prevention or treatment of HPIV3 in both immunocompetent and immunocompromised individuals.
Isolation of the ace1 Gene Encoding a Cys2-His2 Transcription Factor Involved in Regulation of Activity of the Cellulase Promoter cbh1of Trichoderma reesei (2000)

A genetic selection method was developed for the cloning of positive-acting transcriptional regulatory genes in Saccharomyces cerevisiae. The method was applied for the isolation of activators of Trichoderma reesei (Hypocrea jecorina) cellulase genes. Activator genes were isolated from a T. reesei expression cDNA library on the basis of the ability of their translation products to activate transcription from the full-length T. reesei cbh1 promoter coupled to the S. cerevisiae HIS3 gene and to support the growth of the yeast colonies in the absence of histidine. Among the clones obtained was the ace1 gene encoding a novel polypeptide, ACEI, that contains three zinc finger motifs of Cys(2)-His(2) type. Possible ACEI homologues were found among expressed sequence tags of Aspergillus and Neurospora. The ability of ACEI to bind to the cbh1 promoter was further confirmed in the yeast one-hybrid system. In vitro binding and gel mobility shift assays revealed several binding sites for the ACEI protein in the cbh1 promoter. Disruption of the ace1 gene in T. reesei resulted in retarded growth of the fungus on a cellulose-containing medium, on which cellulases are normally highly expressed.
Endoureterotomy for Treatment of Ureteral Strictures (1992)

Advances in endosurgical technology have provided the urological surgeon with an alternative to open surgery for the treatment of ureteral strictures. We report the use of an endoscopic intraureteral incision (endoureterotomy) followed by balloon calibration to treat benign ureteral strictures in 13 patients. With an average subjective and objective followup among successful endoureterotomies of 20 months (all cases 12 months or greater), the overall success rate for this procedure is 62%. Of these patients 5 also received triamcinolone injections into the stricture bed following incision and dilation. This method appeared to influence favorably subsequent ureteral patency. The only operative complication was a urinoma, which resolved without intervention. Endoureterotomy appears to be a safe and reasonably effective modality for the treatment of ureteral stricture disease.
Relative motion discrimination (1991)

Motion of very small amplitudes (5 sec or less) can be detected when the frequency of motion is optimal (2–4 Hz). 1 Previous research has shown that in some conditions, relative motion can be discriminated whenever motion can be detected at all. 2 In this experiment, we determined the range of frequencies over which this relationship holds. We used two sinusoidally oscillating dots to determine the temporal frequency response function of relative motion discrimination. The subject was presented with two dots that either oscillated inphase (the dots moved in the same direction) or in counterphase (the dots moved in opposite directions). The subject was required to discriminate between the two types of motion for a range of temporal frequencies. When the temporal frequency of the presented stimuli is optimal (~4 Hz), the visual system is remarkably adept at discrimination relative motion. However, a temporal frequency of as low as 8 Hz degrades thresholds and 12 Hz increases them by a factor of 5.33 ± 1.33.
WSPEC: A Waveguide Filter Bank Spectrometer (2015)

We have designed, fabricated, and measured a 5-channel prototype spectrometer pixel operating in the WR10 band to demonstrate a novel moderate-resolution (R=f/Δf~100), multi-pixel, broadband, spectrometer concept for mm and submm-wave astronomy. Our design implements a transmission line filter bank using waveguide resonant cavities as a series of narrow-band filters, each coupled to an aluminum kinetic inductance detector (KID). This technology has the potential to perform the next generation of spectroscopic observations needed to drastically improve our understanding of the epoch of reionization (EoR), star formation, and large-scale structure of the universe. We present our design concept, results from measurements on our prototype device, and the latest progress on our efforts to develop a 4-pixel demonstrator instrument operating in the 130-250 GHz band.
Strain characterization of suspended-core fiber tapers (2012)

Suspended core fiber tapers with different cross sections (from 70&mu;m to 120&mu;m diameter) were produced by filament heating. Before obtaining the taper, the spectral behavior of the suspended core fiber presents multimode interference. When the taper is made an intermodal interference is observed. This effect is clearly visible for high taper reduction. The spectral response of the microtaper inside the suspended core fiber is similar to a beat of two interferometers. The microtaper was subjected to strain, and an increase of sensitivity with the reduction of the transverse area was observed. When the taper was immersed in liquids with different refractive indices or subjected to temperature variations, no spectral change occurred.
ROADSIDE SAFETY ANALYSIS PROGRAM (RSAP)--ENGINEER'S MANUAL (2003)

This report presents the findings of a research project to develop an improved cost-effective analysis procedure for assessing roadside safety improvements. The project objective has been accomplished with the development of the Roadside Safety Analysis Program (RSAP). The report will be of particular interest to roadside safety engineers with responsibility for evaluating the impacts of roadside safety improvements. RSAP is based on the encroachment probability approach and incorporates two integrated programs: the Main Analysis Program, which contains the cost-effectiveness procedure and algorithms; and the User Interface Program, which provides a user-friendly environment for data input and review of program results. The cost-effectiveness procedure incorporated into RSAP is based on the concept of incremental benefit-cost analysis. The encroachment model uses roadway and traffic information to estimate the expected encroachment frequency along a highway segment. This report describes the inner workings of the cost-effective analysis procedure and the various algorithms and data sources built into the procedure. A separate User's Manual describing the User Interface Program (including the data input process and the program reports) and the RSAP software are on CRP-CD-33, which is included with this report.
Enterobactin: the characteristic catecholate siderophore of Enterobacteriaceae is produced byStreptomycesspecies (2001)

Enterobactin is described in the literature as the typical iron-chelating compound (siderophore) produced by bacteria of the family Enterobacteriaceae. In the course of a HPLC with diode array detection screening programme for detection of novel secondary metabolites, enterobactin, its biosynthetic precursor 2,3-dihydroxy-N-benzoylserine and its linear dimer and trimer condensation products were found to be produced by two Streptomyces strains besides the trihydroxamate-type siderophores desferri-ferrioxamine B and E.
Platelet-Derived Growth Factor (2006)

Platelet-derived growth factor (PDGF) is a family of isoforms that stimulate the growth, survival, and motility of fibroblasts, smooth muscle cells, and other cell types (reviewed in ref. 1) (Fig. 1). PDGF was originally identified in human platelets and purified from this source; however, subsequent studies have shown that PDGF is synthesized by a number of different cell types.
Roughness of organ pipe sound due to frequency comb (2012)

In the sound spectrum of flue organ pipes in addition to the usual harmonic partials, sometimes a series of equidistant but not harmonic lines can be found. This phenomenon has been observed in the recorded sound of pipes from different pipe ranks. The second set of spectral lines is similar to "frequency combs" used in optics for accurate measurement of optical frequencies. Analysis of measured sound spectra with and without frequency comb and simulations are presented and discussed in the paper. The appearance of frequency combs in the sound spectrum is explained by a model that assumes the presence of a mouth tone in addition to the pipe sound. Mouth tone bursts are generated when the oscillating air jet passes the upper lip. The burst repetition frequency is locked to the fundamental frequency of the pipe and the bursts are coherent with a pulse-to-pulse phase shift. The phase shift explains the observed frequency offset of the frequency comb to the harmonic frequencies. The simulations also show that weak and fluctuating mouth tones cannot generate frequency comb due to a lack of coherence.
Measurement of Macular Fractal Dimension Using a Computer-Assisted Program (2014)

The complexity of the retinal vasculature in the macula can be measured reliably and may be a useful tool to study parafoveal vascular networks in macula diseases, such as diabetic maculopathy.
Relation between the Electronic Properties of Regioregular Donor–Acceptor Terpolymers and Their Binary Copolymers (2020)

By analyzing the optical band gap and energy levels of seven different regioregular terpolymers in which two different electron-rich donor moieties are alternating with a common electron-deficient acceptor unit along the backbone, we establish a direct correlation with the properties of the corresponding binary copolymers in which one donor and one acceptor are combined. For this study, we use diketopyrrolopyrrole as the common acceptor and different π-conjugated aromatic oligomers as donors. We find that the optical band gap and frontier orbital energies of the terpolymers are the arithmetic average of those of the parent copolymers with remarkable accuracy. The same relationship is also found for the open-circuit voltage of the bulk heterojunction solar cells made with the ter- and copolymers in combination with [6,6]-phenyl-C71-butyric acid methyl ester. Comparison of these findings with data in the literature suggests that this is a universal rule that can be used as a tool when designing new π-conjugated polymers. The experimental results are supported by a semiempirical quantum chemical model that accurately describes the energy levels of the terpolymers after parametrization on the energy levels of the copolymers and also provides a theoretical explanation for the observed arithmetic relations.
Foot and Ankle Safety Evaluation in Real Life Crash Situations (2003)

The relation between crash severity and lower leg responses are studied using mathematical models, not only with the 50th percentile Hybrid III dummy, but also using biofidelic feet model and a female dummy model. A number of countermeasures, including toepan padding and foot airbag, were evaluated in a broad spectrum of crash situations, occupant sizes and foot positions. The simulations showed that an airbag in the foot area optimized for the most severe crash reduced forces higher than 3.5 kN in the right tibia in most crash situations. However, tibial axial forces were higher in 50% of the simulations with a foot bag optimized for a severe crash than without foot air bag in various crash conditions. The biofidelic foot and ankle model rotated less than the Hybrid III foot. The difference in tibia load was relatively small between the dummy model and the human foot model. The study shows that an implementation of a countermeasure in cars has to be preceded by an investigation of dummy responses in several crash situations to avoid sub-optimization of the car safety performance. For the covering abstract see E135170.
Robust flux balance analysis of metabolic networks (2011)

Metabolic networks describe the set of biochemical reactions and regulatory interactions of metabolism that govern the phenotypical properties of a cell. Analysis of such networks is critical not only to promote biological knowledge, but also in drug discovery, where it can be used to identify and knockout the targeted pathways. Flux Balance Analysis (FBA) has been widely used to study metabolic networks. This powerful technique employs the reaction stoichiometries and reversibility constraints along with experimental measurements of phenotypical properties of the cell, e.g., biomass composition or ATP synthesis, to compute the fluxes of metabolites that are best manifested in the cell. Although FBA has been shown to satisfactorily capture cell behavior, its performance could be significantly improved if measurement uncertainty is introduced in the models. In this paper we propose Robust Flux Balance Analysis (RFBA) to determine optimal fluxes of metabolites for all phenotypical measurements in a given uncertainty set. We derive a least squares bi-criterion approximation of the uncertain problem and, using the S-procedure and tools from matrix analysis, we show that this is equivalent to a semidef inite program that can be solved optimally using available techniques. We illustrate our approach on synthetic metabolic networks and discuss the effect of regularization on the final solutions. Due to its convex nature, our approach can be applied to genome-scale networks.
Correction: Early management of isolated severe traumatic brain injury patients in a hospital without neurosurgical capabilities: a consensus and clinical recommendations of the World Society of Emergency Surgery (WSES) (2023)

Following publication of the original article [1], in this article the author name Gregory W. J. Hawryluk was incorrectly written as Gregory W. J. Hawrylux. The original article has been corrected.
Optimistic active messages (1995)

Low-overhead message passing is critical to the performance of many applications. Active Messages reduce the software overhead for message handling: messages are run as handlers instead of as threads, which avoids the overhead of thread management and the unnecessary data copying of other communication models. Scheduling the execution of Active Messages is typically done by disabling and enabling interrupts, or by polling the network. This primitive scheduling control, combined with the fact that handlers are not schedulable entities, puts severe restrictions on the code that can be run in a message handler. This paper describes a new software mechanism, Optimistic Active Messages (OAM), that eliminates these restrictions; OAMs allow arbitrary user code to execute in handlers, and also allow handlers to block. Despite this gain in expressiveness, OAMs perform as well as Active Messages.
Drs Sobotka and Bushnell Respond (1993)

The letter from Drs Fitzpatrick and Goldman in response to my epitome is appreciated.'My brief article was not written as a comprehensive review of laser therapy.My intent was to emphasize the fact that lasers are useful in treating skin lesions
Technology Agnostic OSPF Traffic Engineering Extensions for Generalized MPLS (GMPLS) (2010)

This document defines a new approach to Generalized Multiprotocol
Label Switching (GMPLS) bandwidth advertisement aiming at providing
the Network Elements (NEs) and Path Computation Elements (PCEs) with
all the data required for crank-backs minimization and scalability
optimization. A new Open Shortest Path First - Traffic Engineering
(OSPF-TE) routing protocol sub-tlv is defined for bandwidth
advertisement per service type.
Full-wave mutual coupling analysis of wideband arrays based on aperiodic tilings (2009)

This paper will present some of the findings of a full-wave analysis that was performed on an aperiodic tiling array that is based on microstrip patch antennas. Aperiodic tilings have been shown to provide an effective framework for designing planar antenna array layouts with the attractive features of ultra-wide bandwidths and highly sparse distributions. In this investigation selected portions of tilings were replaced by arrays that had an element located at each vertex of the tiling. This coupling tends to manifest itself in the form of radiation patterns and driving point impedances that vary from idealized results.