gebhart/patrepeval huggingface dataset:
Automatic PI Controller Calibration Optimization using Model-Based Calibration Approach (2015)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Model-based calibration (MBC) is a systematic method to calibrate an engine control unit (ECU) system. Due to the working principle of MBC, it is only being used for steady-state systems (time independent models). This limits the use of MBC; because an ECU contains statistical and dynamical systems. Due to the limitations of MBC, dynamical systems require manual tuning which may be time-consuming. With the increasing popularity in hybrid and electrical vehicle systems, most of them rely on dynamical systems. Therefore, MBC is about to be superseded by manual parameterization methods.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;Remarkably, MBC is not limited to the steady state systems. It can be achieved by separating the time factor of a system and extracting the statistical data from a time series measurement. Typically, MBC model is conceived as the representation of a system plant (i.e.: air path, fuel path, mean value engine model). As a matter of fact, MBC model is not limited to identification of system plant. By removing the time factor from the controller's performance, it enables the MBC to model the system performance and optimize the controller's parameters. The benefits of modeling a system's performance using MBC approach, are employing radial basis function network which is known for its modeling accuracy for highly non-linear systems.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;This paper presents the working principle of calibrating a PI controller for a fuel transport delay plant using Model-based calibration method. The PI controller is used for controlling the injected fuel mass flow depending on the lambda set point input. The outcome of the automatic calibration process is a series of optimized gain scheduled tables for the fuel PI controller. This paper is to prove there's fine line between calibrating a statistical and dynamical system using Model-based Calibration method.&lt;/div&gt;&lt;/div&gt;
Antimicrobial mechanism of resveratrol‐trans‐dihydrodimer produced from peroxidase‐catalyzed oxidation of resveratrol (2015)

Plant polyphenols are known to have varying antimicrobial potencies, including direct antibacterial activity, synergism with antibiotics and suppression of bacterial virulence. We performed the in vitro oligomerization of resveratrol catalyzed by soybean peroxidase, and the two isomers (resveratrol-trans-dihydrodimer and pallidol) produced were tested for antimicrobial activity. The resveratrol-trans-dihydrodimer displayed antimicrobial activity against the Gram-positive bacteria Bacillus cereus, Listeria monocytogenes, and Staphylococcus aureus (minimum inhibitory concentration (MIC) = 15.0, 125, and 62.0 μM, respectively) and against Gram-negative Escherichia coli (MIC = 123 μM, upon addition of the efflux pump inhibitor Phe-Arg-β-naphthylamide). In contrast, pallidol had no observable antimicrobial activity against all tested strains. Transcriptomic analysis implied downregulation of ABC transporters, genes involved in cell division and DNA binding proteins. Flow cytometric analysis of treated cells revealed a rapid collapse in membrane potential and a substantial decrease in total DNA content. The active dimer showed >90% inhibition of DNA gyrase activity, in vitro, by blocking the ATP binding site of the enzyme. We thus propose that the resveratrol-trans-dihydrodimer acts to: (1) disrupt membrane potential; and (2) inhibit DNA synthesis. In summary, we introduce the mechanisms of action and the initial evaluation of an active bactericide, and a platform for the development of polyphenolic antimicrobials.
[Results of the epidemiology of lung cancer in females]. (1990)

In the context with an extensive pilot study investigating risk factors for lung cancer, aetiological and clinical questions were analysed for lung cancer mortality in women. In a first step all available data sources about the prevalence of smoking in the FRG were used to determine the correlation between the prevalence of smoking and lung cancer mortality. 88% of the variance (R2) of lung cancer mortality for women could be explained by smoking. In a second step medical records of 133 female lung cancer patients from three hospitals were analysed with regard to the histological types of lung cancer and smoking. Small cell lung cancers were more frequent among female smokers while adenocarcinoma was more prevalent among non-smokers. Survival analysis for 421 men and 97 women showed a significantly longer survival time for women as compared to men, taking into account other relevant prognostic factors. The association between smoking and lung cancer is discussed and analysed in greater detail.
Reliability-based mesh-to-grid image reconstruction (2016)

This paper presents a novel method for the reconstruction of images from samples located at non-integer positions, called mesh. This is a common scenario for many image processing applications, such as super-resolution, warping or virtual view generation in multi-camera systems. The proposed method relies on a set of initial estimates that are later refined by a new reliability-based content-adaptive framework that employs denoising in order to reduce the reconstruction error. The reliability of the initial estimate is computed so stronger denoising is applied to less reliable estimates. The proposed technique can improve the reconstruction quality by more than 2 dB (in terms of PSNR) with respect to the initial estimate and it outperforms the state-of-the-art denoising-based refinement by up to 0.7 dB.
Student Involvement in Improving the Culture of Safety in Academic Laboratories (2013)

An effective way of addressing the need for an improved culture of safety in research-intensive science departments is described, which involves enabling leadership by graduate student and postdoctoral associate laboratory safety officers (LSOs). In partnership with The Dow Chemical Company, LSOs from the Departments of Chemistry and Chemical Engineering and Materials Science at the University of Minnesota formed a Joint Safety Team. With helpful input from Dow, the team has played a key role in improving the culture and practice of safety in both departments, providing support for use of this model for inculcating safety as a core value and an integral part of academic life.
Unsupervised Domain Generalization by Learning a Bridge Across Domains (2021)

The ability to generalize learned representations across significantly different visual domains, such as between real photos, clipart, paintings, and sketches, is a fundamental capacity of the human visual system. In this paper, different from most cross-domain works that utilize some (or full) source domain supervision, we approach a relatively new and very practical Unsupervised Domain Generalization (UDG) setup of having no training supervision in neither source nor target domains. Our approach is based on self-supervised learning of a Bridge Across Domains (BrAD) - an auxiliary bridge domain accompanied by a set of semantics preserving visual (image-to-image) mappings to BrAD from each of the training domains. The BrAD and mappings to it are learned jointly (end-to-end) with a contrastive self-supervised representation model that semantically aligns each of the domains to its BrAD-projection, and hence implicitly drives all the domains (seen or unseen) to semantically align to each other. In this work, we show how using an edge-regularized BrAD our approach achieves significant gains across multiple benchmarks and a range of tasks, including UDG, Few-shot UDA, and unsupervised generalization across multi-domain datasets (including generalization to unseen domains and classes).
Abstract 5267: Unbiased metabolic profiling of atypical teratoid/rhabdoid tumors predicts sensitivity to the glutamine metabolic inhibitor 6-diazo-5-oxo-L-norleucine (2019)

Atypical teratoid rhabdoid tumors (AT/RT) are deadly tumors of infancy in need of new, targeted therapies. Molecular analyses have revealed 3 epigenetically distinct subgroups of AT/RT. High MYC-expressing tumors are a particularly aggressive subgroup, with a 5-year median survival of 18.5%. MYC is difficult to directly target given large, flat, featureless protein-protein binding sites. We performed the first unbiased metabolic profile of AT/RT cell models by high-performance liquid chromatography-mass spectrometry. This study revealed that high MYC-expressing AT/RT have a unique metabolic profile (Partial Least Squares-Discriminant Analysis). Pathway analysis highlights a dependence on glutamine metabolism in high-MYC expressing AT/RT. High MYC-expressing cell lines grow poorly in glutamine-free media compared to low-MYC cell lines (MTS assay, glutamine-free media vs normal media). Due to this dependence on glutamine metabolism, we hypothesized that high-MYC expressing AT/RT would be especially sensitive to glutamine metabolic inhibitors. We show that the glutamine analogue, 6-diazo-5-oxo-L-norleucine (DON) slows high-MYC expressing AT/RT cell growth, induces high rates of apoptosis, and improves survival in orthotopic mouse models of high-MYC expressing AT/RT (p =0.0027 by log-rank test). In contrast, low-MYC expressing models are relatively insensitive to DON. In uniformly labeled glutamine metabolic analyses of AT/RT cells, DON treatment led to depletion of glutathione levels by preventing the production of glutamate. DON treatment synergized with carboplatin to kill AT/RT cells in vitro and extend the life of mice bearing AT/RT orthotopic xenografts (p Citation Format: Sabrina Z. Wang, Brad Poore, Jesse Alt, Antoinette Price, Sariah Allen, Brent Orr, Rana Rais, Barbara Slusher, Charles Eberhart, Eric H. Raabe, Jeffrey H. Rubens. Unbiased metabolic profiling of atypical teratoid/rhabdoid tumors predicts sensitivity to the glutamine metabolic inhibitor 6-diazo-5-oxo-L-norleucine [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5267.
Sequencing [4 + 1]-Cycloaddition and Aza-Michael Addition Reactions: A Diastereoselective Cascade for the Rapid Access of Pyrido[2′,1′:2,3]/Thiazolo[2′,3′:2,3]imidazo[1,5-a]quinolone Scaffolds as Potential Antibacterial and Anticancer Motifs (2019)

The design and synthesis of a quality compound library containing a small number of skeletally diverse scaffolds, whose members rapidly deliver new chemical probes active against multiple phenotypes, is paramount in drug discovery. In this context, an efficient one-pot strategy for the synthesis of a mini library of sp<sup>3</sup>-enriched hexahydropyrido[2',1':2,3]imidazo[1,5-<i>a</i>]quinolinium and hexahydrothiazolo[2',3':2,3]imidazo[1,5-<i>a</i>]quinolinium architectures, is described. This new one-pot method features a combination of Sc(OTf)<sub>3</sub>-catalyzed [4 + 1]-cycloaddition with aza-Michael addition reactions. The cascade results in a rapid and diastereoselective formation of these scaffolds via desymmetrization of the oxidative dearomatization products of phenols. Phenotypic screening of the mini library against multiple drug-resistant bacteria and a panel of cancer cell lines identified potential antibacterial and anticancer lead drug candidates. Further investigation of the anticancer leads, indicated by their activity as tubulin-polymerization inhibitors, represents a promising approach for cancer therapy.
Three-dimensional spatial coherence measurements: Vertical, longitudinal/transverse horizontal coherence. (2008)

In the Shallow Water ’06 experiment, two L-shape arrays were deployed. Two horizontal components of these arrays were laid on the sea bottom. One was exactly perpendicular to the direction of sound propagation. The other was exactly parallel to the direction of sound propagation. This configuration offered an opportunity to directly measure the vertical, longitudinal horizontal, and transverse horizontal coherence. The results of spatial coherence were averaged over different pairs of hydrophones and over a frequency bandwidth of 100 Hz. The vertical coherence showed receiver depth dependence. When the source and the receivers were located below the thermocline, both the vertical and longitudinal horizontal coherence lengths (in units of wavelength) increased with increasing range and frequency. The longitudinal horizontal coherence length was much larger than the vertical coherence length. These results were similar to the predictions by Smith’s model [J. Acoust. Soc. Am. 60, 305–310 (1976)] with a frequency dependent bottom reflection loss [Zhou, Chin. Phys. 1, 494–504 (1981)]. The transverse horizontal coherence length/wavelength decreased with frequency. When the source depth was within the thermocline, the transverse horizontal coherence lengths exhibited weak range dependence in the 100–300 Hz range and was larger than 40 wavelengths. [Work supported by ONR.]
P03.05: Report of a case of right ductus arteriosus in a fetus with right aortic arch (2009)

Aortic arch anomalies refer to a variety of congenital abnormalities involving aortic arch course and/or branching pattern. Those commonly seen include right aortic arch with aberrant left subclavian artery, left aortic arch with aberrant right subclavian artery, right aortic arch with mirror-image branching, double aortic arch and circumflex retroesophageal aortic arch. Reviewing of 10 years literature showed no report of antenatal diagnosis of right ductus arteriosus, however there are reports of right ductus arteriosus diagnosed postnatally by MRI, angiography, cardiac catheterization, 2D echocardiogram. Interestingly some were discovered during ligation of PDA. We report a case of a ductus arteriosus in a fetus with right aortic arch. A 28-year-old woman, gravida 2 para 1, had routine second trimester ultrasound examination in our antenatal diagnostic center at 21.3weeks. We found a right aortic arch and right ductal arch on 3 vessel and trachea (3VT) view. The thymus was visualized. The rest of fetal structures appeared normal. A normal fetal karyotype (46,XX) was found, with no evidence of microdeletion of chromosome 22q on fluorescence in-situ hybridization. Patient delivered a female infant by vaginal birth at 36.7week's gestation. After delivery, echocardiography was done, and moderate perimembranous ventricular septal defect was found. The baby was well and no complications were found. Right aortic and right ductal arch can be diagnosed prenatally, with the use of the 5 plane views of Yagel, especially with the 3VT view. Isolated right aortic arch and the right ductal arch is a benign vascular anomaly with no known postnatal complications. However, a detailed evaluation of the fetal cardiac structures and karyotying has to be considered due to its association with cardiac/non-cardiac malformations and microdeletion 22q11 syndrome. Right ductal arch is rare and should be diagnosed before ligation of PDA in the neonates.
Chemically Delaminated Free‐Standing Ultrathin Covalent Organic Nanosheets (2016)

Covalent organic nanosheets (CONs) are a new class of porous thin two-dimensional (2D) nanostructures that can be easily designed and functionalized and could be useful for separation applications. Poor dispersion, layer restacking, and difficult postsynthetic modifications are the major hurdles that need to be overcome to fabricate scalable CON thin films. Herein, we present a unique approach for the chemical exfoliation of an anthracene-based covalent organic framework (COF) to N-hexylmaleimide-functionalized CONs, to yield centimeter-sized free-standing thin films through layer-by-layer CON assembly at the air-water interface. The thin-layer fabrication technique presented here is simple, scalable, and does not require any surfactants or stabilizing agents.
Differential COX localization and PG release in Thy-1+ and Thy-1− human female reproductive tract fibroblasts (2002)

A key role exists for prostaglandins (PGs) in reproductive health, including fertility and parturition. However, the cellular sources and regulation of PG production by cyclooxygenase (COX) in the human female reproductive tract remain poorly understood. We recently reported that human female reproductive tract fibroblasts are divisible into distinct subsets based on their Thy-1 surface expression. Herein, we demonstrate that the expression, induction, and subcellular localization of COX-1 and COX-2 and the downstream PG biosynthesis are markedly different between these subsets. Specifically, Thy-1(+) fibroblasts highly express COX-1, which is responsible for high-level PGE(2) production, a feature usually attributed to the COX-2 isoenzyme. In contrast, COX-2, generally considered an inducible isoform, is constitutively expressed in the Thy-1(-) subset, which only minimally produces PGE(2). The intracellular signaling pathways for COX regulation also differ between the subsets. Determination of differences in signal transduction, COX expression and localization, and PG production by human reproductive fibroblast subtypes supports the concept of fibroblast heterogeneity and the possibility that these subsets may play unique roles in tissue homeostasis and in inflammation.
Maytansine derivatives and metabolites of antibody-maytansinoid conjugates inhibit microtubule polymerization and strongly suppress microtubule dynamics (2008)

1406 Maytansine is a potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at sub-nanomolar concentrations. Maytansine analogs, DM1 and DM4 (collectively DMx), were conjugated to monoclonal antibodies that selectively bind to antigens expressed on the surface of cancer cells. These antibody-maytansinoid conjugates displayed antigen-specific cytotoxicity in vitro and potent anti-tumor activity in vivo. Several antibody-DM1 and antibody-DM4 conjugates are currently undergoing clinical evaluation. We have investigated the ability of maytansinoid derivatives and metabolites derived from antibody-maytansinoid conjugates to inhibit microtubule polymerization and to suppress dynamic instability of microtubules assembled from bovine brain tubulin. In addition, we examined the stoichiometry of binding to microtubules and dissociation constant (Kd) of one thioether derivative, S-methyl DM1 (DM1-Me). DM1-Me inhibited the assembly of tubulin in a concentration-dependent manner with an IC50 of 4 ± 0.1 µM. Using 3[H]DM1-Me, we found that this compound binds to microtubules in a concentration-dependent fashion with a stoichiometry of 33 molecules of DM1-Me bound per microtubule at 0.1 µM. The dissociation constant (Kd) for the binding of DM1-Me to microtubules is found to be 0.4 µM, indicating strong binding of the maytansinoid to microtubules. The effects of DM1-Me, DM4-Me (S-methyl DM4) and several major target cell-derived metabolites of antibody-DM1 and antibody-DM4 conjugates on microtubule dynamic instability were studied by real-time imaging of axoneme-seeded microtubules assembled from bovine brain tubulin using differential interference contrast microscopy. The maytansinoids (0.1 µM) strongly suppressed microtubule dynamics. For instance, DM1-Me decreased the growing and shortening rates of microtubules by 24% and 67%, respectively. In addition, DM1-Me suppressed catastrophe and rescue frequencies by 90 % and 44 %, respectively. The overall dynamicity of microtubules was decreased by 87% by DM1-Me, and by 74% by DM4-Me. DM1-Me, DM4-Me and several of the target cell-derived metabolites were more potent than the parent compound maytansine, which suppressed the dynamicity of microtubules by 52%. These data, along with the previous finding of the low systemic toxicity and favorable pharmacokinetic behavior of antibody-maytansinoid conjugates bolsters the potential of DMx conjugates in cancer chemotherapy. Supported by grants NIH CA 57291 and NS13560.
Reinforcement Learning for Volt- Var Control: A Novel Two-stage Progressive Training Strategy (2022)

This paper develops a reinforcement learning (RL) approach to solve a cooperative, multi-agent Volt-Var Control (VVC) problem for high solar penetration distribution systems. The ingenuity of our RL method lies in a novel two-stage progressive training strategy that can effectively improve training speed and convergence of the machine learning algorithm. In Stage 1 (individual training), while holding all the other agents inactive, we separately train each agent to obtain its own optimal VVC actions in the action space: {consume, generate, do-nothing}. In Stage 2 (cooperative training), all agents are trained again coordinately to share VVC responsibility. Rewards and costs in our RL scheme include (i) a system-level reward (for taking an action), (ii) an agent-level reward (for doing-nothing), and (iii) an agent-level action cost function. This new framework allows rewards to be dynamically allocated to each agent based on their contribution while accounting for the trade-off between control effectiveness and action cost. The proposed methodology is tested and validated in a modified IEEE 123-bus system using realistic PV and load profiles. Simulation results confirm that the proposed approach is robust, and computationally efficient and achieves desirable volt-var control performance under a wide range of operation conditions.
Stress Corrosion Cracking Research at Sandia National Labs. (2021)

Abstract not provided.
Direct coronal view of the shoulder with arthrographic CT. (1993)

Direct coronal oblique views of the shoulder were obtained with arthrographic computed tomography (CT) in 35 shoulders with surgical correlation. There were 18 complete cuff tears, four partial ones, two type 3 superior labral, anterior, and posterior (SLAP) lesions, and one type 4 SLAP lesion. The coronal sections were obtained after double-contrast shoulder arthrography and axial CT sections had already been obtained. The patient was seated directly on the slope of the gantry, and the shoulder to be studied was positioned in the center of the gantry. The maximal time needed for this procedure was 5 minutes. Rotator cuff tears were detected with a sensitivity of 95% and a specificity of 100%. The size of the tears as determined on the coronal sections was strongly correlated with surgical measurement (r = .939). All SLAP lesions were detected. The authors' experience shows that obtaining coronal oblique sections is an effective way to improve arthrographic CT.