gebhart/patrepeval huggingface dataset:
Dose-dense (DD) doxorubicin and cyclophosphamide (AC) followed by weekly paclitaxel (P) with trastuzumab (T) and lapatinib (L) in HER2/neu-positive breast cancer is not feasible due to excessive diarrhea: updated results. (2009)

Abstract Abstract #2108 Background: DD q 2 weekly (w) AC → P + T x 1 year (y) has an acceptable safely profile w/ congestive heart failure (CHF) rate of 1/70 pts (Dang, JCO 2008). Lapatinib (L) is effective in HER2 (+) BC. We conducted a pilot study of dd AC → w P + T + L to determine its feasibility and cardiac safety.&amp;#x2028; Methods: Enrolled pts had HER2 (+) BC; LVEF &amp;gt; 50%. Rx consisted of AC at 60/600 mg/m2 x 4 q 2 w (w/ pegfilgrastim 6 mg day 2) → P at 80 mg/m2 x 12 q w + T x 1 y; L (1000 mg daily beginning w/ P + T and continued x 1 y). MUGA is obtained at baseline and at months (mo) 2, 6, 9, and 18. Rx is considered feasible if 1) &amp;gt; 80% pts can complete the PTL phase without a dose delay or reduction and 2) the cardiac event rate (CHF or cardiac death) is &amp;lt; 4%. Pts can remain on-Rx w/ one dose reduction of L (1000 mg → 750 mg) for a G 3 event or &amp;lt; G 3 toxicity (unacceptable).&amp;#x2028; Results: From March 2007 to April 2008, we enrolled 95 pts. Median (med) age was 45 years (range, 28-73). At a med follow-up of 7 months, 90 are evaluable. Of the 90 pts, 34 (37%) withdrew from study during the PTL phase; 29 for a 2nd event of G 3 or unacceptable &amp;lt; G 3 toxicities (15 G 3 diarrhea, 4 G 1/2 diarrhea, 1 G 3 rash, 2 G 2 rash, 1 G 3 dyspnea and also had G 3 diarrhea, 1 G 3 ↑QTc also had G 3 diarrhea, 1 G 3 ↑ALT also had G 3 diarrhea, 1 G 3 paronychia, 1 G 3 pneumonitis, 1 asymptomatic LVEF ↓, 1 myocarditis) and 5 for other reasons (2 personal reason, 1 PCP pneumonia, 1 progression, 1 P hypersensitivity). Overall, 25/90 (27%) pts had G 3 diarrhea and 31/90 (34%) pts required a dose reduction of lapatinib. Med LVEF at baseline is 67% (N=95), at mo 2 is 68% (N=90), at mo 6 is 65% (N=53), and mo 9 is 65% (N=28). To date there are no patient drop-outs due to significant LVEF declines after dd AC; one patient dropped during PTL out due to an asymptomatic LVEF decline.&amp;#x2028; Discussion: L at 1000 mg/day is not feasible combined w/ weekly P and T by protocol stipulation (&amp;gt; 20% pts required L dose reduction) primarily due to excessive G 3 diarrhea. These results have led to the modification of Design 2 (Arm D) of ALTTO. We will report updated results. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 2108.
Homossexualidade, homoerotismo e género em O Filho de Mil Homens, de Valter Hugo Mãe (2020)

Resumo Neste artigo, discuto a presença e os enquadramentos técnicos e ideológicos dos problemas da homossexualidade, do homoerotismo e do género (masculino/feminino) no romance O Filho de Mil Homens (2011), do português Valter Hugo Mãe (1971). Convoco quer as principais teorias que propõem explicações para a homossexualidade e a identidade de género quer as visões de alguns autores que, não filiados em nenhuma teoria, escreveram sobre o tema, como Michel Foucault, John Thorp ou Judith Butler.
ChemInform Abstract: First Total Synthesis of 11‐Oxa Steroids. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Direct comparison of mid-regional pro-atrial natriuretic peptide with N-terminal pro B-type natriuretic peptide in the diagnosis of patients with atrial fibrillation and dyspnoea (2012)

In AF patients, NT proBNP and MR proANP have similar diagnostic value for the diagnosis of AHF. The rhythm at presentation has to be taken into account because plasma levels of both peptides are significantly higher in patients with AF compared with SR.
Development of Laser-Based Variation Mapping Techniques – Another Way to Increase the Successful Analysis Rate on Analog & Mixed-Mode ICs (2009)

Abstract The failure localization on analog &amp; mixed mode ICs in functional mode (AC signals) has become more and more challenging in the last few years. Due to an increasing integration and complexity of these devices, the number of defects, especially those named “soft”, raised considerably. The classical Dynamic Laser Stimulation (DLS) techniques showed some limitations when applied to analog &amp; mixedmode ICs. The SDL (Soft Defect Localization) technique [1] based on binary output signal allows us to localize only the most sensitive areas. The defect in this type of circuits, which are very sensitive to the laser beam [2], is often characterized by a weaker sensitivity than that of “healthy” regions. Hence, xVM (Variation Mapping) techniques were introduced to map some parameters in an analog way (the different sensitivity levels are visualized). To date, the T-LSIM technique [3], the Delay and the Phase Variation Mapping techniques were published [4, 5]. We have already had some interesting results by using these techniques [6] but not every “soft” defect case study could be resolved in that way. In this paper we propose to look at some different parameters which characterize an analog signal and can be used as an input for laser mapping. By applying a simple setup, without any additional sophisticated tool, we show on a “golden” commercial IC the added value of this analysis. We also deal with amplifying the weak signal variations induced by the laser beam scan which often are hidden by the high signal variations in analog or mixed-mode ICs.
AM-FM Conversion by the Active Devices in MOS LC-VCOs and its Effect on the Optimal Amplitude (2006)

Large oscillation amplitudes in differential MOS LC-VCOs change the operation region of the MOS negative-resistance devices and thus modulate their parasitic capacitances. As a result, the effective tank capacitance and the oscillation frequency change with respect to the oscillation amplitude for a fixed tuning voltage. The resulting frequency-versus-amplitude curve has a maximum for differential amplitude approximately equal to the threshold voltage of the MOS devices which corresponds to the optimum amplitude that minimizes AM-to-FM conversion. The presented analysis is confirmed with simulation and measurement results for a 2 GHz differential NMOS VCO fabricated in a 0.25 mum BiCMOS process. The optimum amplitude for lowest AM-to-FM conversion also yields the lowest phase noise for this oscillator
INTUICIÓN, SESGOS Y HEURÍSTICAS EN LA ELECCIÓN (2009)

Heuristics and Biases research program led by economist A. Tversky (who died in 1996) and by the Nobel Prize winning psychologist D. Kahneman, has provided since 1971 an alternative approach to the Expected Utility Model in the field of decision making. Assertions of this descriptive theory focused on the psychological aspects affecting individual choice, called The Prospect question the normative status of Rational Choice Theory, its underlying assumptions and it predictive pretension. This article aims to provide a contrast between the two theories.
A CMOS Temperature-to-Frequency Converter With an Inaccuracy of Less Than $\pm \hbox{0.5}\,^{\circ}{\hbox{C}}$ (3$\sigma$) From $-\hbox{40}\,^{\circ}\hbox{C}$ to 105$\,^{\circ}\hbox{C}$ (2006)

This paper describes a temperature-to-frequency converter (TFC) implemented in a standard CMOS process. Its output frequency is determined by the phase-shift of an electrothermal filter, which consists of a heater and a temperature sensor realized in the substrate of a standard CMOS chip. The filter's phase-shift is determined by the geometry of the thermal path between the heater and the sensor, and by the temperature-dependent rate at which heat diffuses through the substrate. The resulting temperature-dependent phase-shift is quite well-defined, since filter geometry is defined by lithography, while the thermal diffusivity of the high-purity lightly-doped silicon substrate is essentially constant. The filter was used as the frequency-determining component of a frequency-locked loop (FLL), whose output frequency is then a well-defined function of temperature. Using this approach, a TFC with an inaccuracy of plusmn0.5degC (3sigma) over the industrial temperature range (-40degC to 105 degC) has been realized in a standard 0.7-mum CMOS process
Mean radiative lifetime of vibrationally excited /v equals 9/ hydroxyl - Rate of the reaction of vibrationally excited hydroxyl /v equals 9/ with ozone (1971)

Vibrationally excited ground state hydroxyl in fast flow system, considering mean radiative lifetime and reaction rate with ozone
Calculation of atomic positions in nanometer-scale direct-write optical lithography with an optical standing wave (1994)

Recent experiments have shown that the light pressure force that is due to an optical standing wave (SW) focuses an atomic beam to submicrometer dimensions. We calculate some theoretical limits on the focusing of a sodium atomic beam by a SW optical field.
A novel antagonist of CRTH2 blocks eosinophil release from bone marrow, chemotaxis and respiratory burst (2007)

These data further emphasize the importance of CRTH2 in eosinophil function and show that Cay10471 is a highly potent and selective antagonist of PGD(2)-induced eosinophil responses. Cay10471 might hence be a useful compound for the treatment of allergic diseases.
Typeface Completion with Generative Adversarial Networks (2018)

The mood of a text and the intention of the writer can be reflected in the typeface. However, in designing a typeface, it is difficult to keep the style of various characters consistent, especially for languages with lots of morphological variations such as Chinese. In this paper, we propose a Typeface Completion Network (TCN) which takes one character as an input, and automatically completes the entire set of characters in the same style as the input characters. Unlike existing models proposed for image-to-image translation, TCN embeds a character image into two separate vectors representing typeface and content. Combined with a reconstruction loss from the latent space, and with other various losses, TCN overcomes the inherent difficulty in designing a typeface. Also, compared to previous image-to-image translation models, TCN generates high quality character images of the same typeface with a much smaller number of model parameters. We validate our proposed model on the Chinese and English character datasets, which is paired data, and the CelebA dataset, which is unpaired data. In these datasets, TCN outperforms recently proposed state-of-the-art models for image-to-image translation. The source code of our model is available at https://github.com/yongqyu/TCN.
ChemInform Abstract: Oxepanes from an Unusual Acetal Cleavage of 6,8‐Dioxabicyclo(3.2.1) octanes. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
NK Cells Contribute Significantly to the Innate Immune Effector Role of CD37-Specific SMIP in CLL and NHL. (2006)

Abstract CD37 is a lineage-specific B-cell antigen that represents an attractive target for immunotherapy in B-cell malignancies, especially in chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma (NHL). CD37-specific small modular immuno pharmaceutical (CD37-SMIP™) drug is an engineered protein therapeutic directed to the CD37 antigen using a single chain variable region (scFv) linked to a modified human IgG1 hinge, CH2, and CH3 domains. We have previously presented that CD37-SMIP™ drug induces both ADCC and apoptosis against primary CLL cells and B-cell lymphoma cells and therapeutic efficacy was observed in a Raji cell disseminated leukemia xenograft model. Herein, we sought to determine the effector cell type(s) mediating ADCC and explore if agents that deplete NK cell inhibitory T-regulatory cells influence CD37-SMIP™ efficacy. Immunostaining of human peripheral blood mononuclear cells (PBMCs) from CLL patients demonstrated no expression of CD37 on CD3+ T cells, CD16+ or CD56+ NK cells, or CD64+ monocytes whereas CD37 was highly expressed on CD19+ B cells. Using purified human PBMCs as effector cells and Cr-51 labelled CLL B cells as targets, we found the CD37-SMIP™ dependent ADCC was predominantly mediated by NK cells, but not naïve or activated monocytes. Consistent with these in-vitro results, the in-vivo therapeutic efficacy of CD37-SMIP™ drug was significantly compromised by depletion of NK cells in the Raji cell disseminated leukemia xenograft SCID mouse model. The median survival time of CD37-SMIP™ treated mice decreased from 51 days (95% CI: 38, 78) to 27 days (95% CI: 25, 37) (p=0.017) with the depletion of NK cells. Consistent with previous studies, ADCC is not diminished by fludarabine, an agent that may deplete T-regulatory cells, suggesting that the anti-CD37 protein and fludarabine might combine for increased efficacy in-vivo. We therefore examined the effect of fludarabine on CD37-SMIP™ in-vitro apoptotic activity. These data demonstrate that direct cell death mediated by CD37-SMIP™ drug (5 ug/mL) synergizes with fludarabine-induced caspase-dependent apoptosis, as measured by both the MTT assay and annexin V/PI staining of CLL cells (combination index, CI=0.44). Overall, these data suggest that the CD37-SMIP™ is a promising therapeutic agent against CD37+ B-cell malignancies as either monotherapy or in combination with fludarabine. Further clinical development is warranted to investigate the effect of CD37-SMIP™ drug in CLL and NHL. (SMIP trademark is owned by Trubion Pharmaceuticals).
Tepidisphaera mucosa gen. nov., sp. nov., a moderately thermophilic member of the class Phycisphaerae in the phylum Planctomycetes, and proposal of a new family, Tepidisphaeraceae fam. nov., and a new order, Tepidisphaerales ord. nov. (2014)

Three strains of facultatively aerobic, moderately thermophilic bacteria were isolated from terrestrial hot springs in Baikal Lake region and Kamchatka (Russia). Cells of the new isolates were cocci reproducing by binary fission. The temperature range for growth was between 20 and 56 °C and the pH range for growth from pH 4.5 to 8.5, with optimal growth at 47-50 °C and pH 7.0-7.5. The organisms were chemoheterotrophs preferring sugars and polysaccharides as growth substrates. 16S rRNA gene sequences of strains 2842, 2813 and 2918Kr were nearly identical (99.7-100 % similarity) and indicated that the strains belonged to the phylum Planctomycetes. The phylogenetically closest cultivated relatives were Algisphaera agarilytica 06SJR6-2(T) and Phycisphaera mikurensis FYK2301M01(T) with 16S rRNA gene sequence similarity values of 82.4 and 80.3 %, respectively. The novel strains differed from them by higher growth temperature, sensitivity to NaCl concentration above 3.0 % and by their cellular fatty acids profile. On the basis of phylogenetic and physiological data, strains 2842(T), 2813 and 2918Kr represent a novel genus and species for which we propose the name Tepidisphaera mucosa sp. nov. The type strain is 2842(T) ( = VKM B-2832(T) = JCM 19875(T)). We also propose that Tepidisphaera gen. nov. is the type genus of a novel family, Tepidisphaeraceae fam. nov. and a novel order, Tepidisphaerales ord. nov.
Iterative reconstruction of an all-focused image by using multiple differently focused images (2002)

In this paper, we propose a novel method of all-focused image acquisition using multiple differently focused images. Based on the assumption that depth of the scene changes stepwise, we derive a formula for reconstruction between the desired all-focused image and multiple acquired images; we can reconstruct the all-focused image by iterative use of the formula. We also introduce coarse-to-fine estimation of point spread functions of the acquired images. We show we can reconstruct an all-focused image for a natural scene.
Colloidal Random Terpolymers: Controlling Reactivity Ratios of Colloidal Comonomers via Metal Tipping (2016)

We report on a versatile synthetic method of preparing colloidal copolymers and terpolymers composed of dipolar Au@Co core-shell nanoparticles (NPs) in the backbone, along with semiconductor CdSe@CdS nanorod (NR), or tetrapod (TP) side chain groups. A seven-step colloidal total synthesis enabled the synthesis of well-defined colloidal comonomers composed of a dipolar Au@CoNP attached to a single CdSe@CdS NR, or TP, where magnetic dipolar associations between Au@CoNP units promoted the formation of colloidal co- or terpolymers. The key step in this synthesis was the ability to photodeposit a single AuNP tip onto CdSe@CdS NR or TP that enables selective seeding of a dipolar CoNP onto the AuNP seed. We show that the variation of the AuNP size directly controlled the size and dipolar character of the CoNP tip, where the size modulation of the Au and Au@CoNP tips is analogous to control of comonomer reactivity ratios in classical copolymerization processes.
An alternative method to introduce fine Y2BaCuO5 precipitates into YBa2Cu3Ox with enhanced flux pinning (1994)

We have examined the effect of fine Y2BaCuO2 (211) precipitates on the flux pinning in textured YBa2Cu3Ox (123). We have used an alternative method to introduce fine Y2BaCuO5 (211) precipitates in YBa2Cu3Ox (123) without melting at high temperatures and without subsequent quenching as in the quench melt growth (QMG) process. Instead of generating the liquid by heating above 1200°C as in the QMG method, we obtain the liquid composition by a solid-state route at much lower temperatures. The microstructure achieved by using this alternative method is similar to that achieved by the quench-melt-growth process. We show that the fine 211 precipitates produced by this process can effectively enhance flux pinning.
Molecular Recognition of a Monoclonal Antibody (AC1106) Cross-Reactive for Derivatives of Ru(bpy)32+ and Ru(phen)32+ (1996)

The characterization of a monoclonal antibody (AC1106) elicited via immunization with a Co(dmbpy)(bpy)23+−methyl viologen hapten (1) is described. AC1106 was found cross-reactive for a variety of luminescent ruthenium(II) metal complexes which served as useful probes to investigate the molecular recognition properties of this antibody. AC1106 was found to be specific for methylated derivatives of Ru(bpy)32+ and Ru(phen)32+ in the order of Ru(dmbpy)32+ > Ru(dmbpy)(bpy)22+ > Ru(dmphen)32+ > Ru(bpy)32+ ≫ Ru(phen)32+. The affinities of AC1106 for these metal complexes were found to range from ≥ 5 × 107 to ≤ 1 × 103 M-1. When bound (>98%) by AC1106, the luminescence decay traces for the racemic Ru(dmbpy)32+ and Ru(dmbpy)(bpy)22+ gave a satisfactory fit to a single-exponential decay process. Furthermore, D2O/H2O experiments with Ru(dmbpy)32+ indicate that AC1106 protects approximately 70% of the antibody-bound Ru(dmbpy)32+ from excited state deactivation by the solvent. Competition ELISA data indicate that both the metal center and the methyl viologen moiety present in a Ru(bpy)32+−methyl viologen conjugate ([Ru(mv2+-bpy)(bpy)2]4+) are important recognition elements for AC1106. Despite the apparent affinity of AC1106 for methyl viologen, no evidence for simultaneous binding of methyl viologen and Ru(dmbpy)(bpy)22+ inside the binding pocket of AC1106 could be found. Rather, the addition of methyl viologen was found to result in the displacement of AC1106-bound Ru(dmbpy)(bpy)22+ from the antibody binding site.
Design of optically active nanoclusters of gold particles with mesostructured silica coating (2009)

Monodispersed, nanosized gold-mesoporous silica nanospheres in the size range 80–280 nm with specific optical properties are prepared in two steps: i) controlled aggregation of gold nanoparticles (GNP) in nanoclusters embedded in a uniform coating of amorphous silica, and ii) development of a porous regular and ordered silica shell by pseudomorphic transformation of the external layer. By careful manipulation of the synthesis variables, i.e., the concentration of co-solvent, surfactant and alkali, it is possible to obtain nanoparticles with controlled morphological and textural characteristics and desired optical behaviour. An optimized sample with most of the nanoparticles containing a multinucleus core made of 10 or more GNP shows a strong absorption cross-section in the near-infrared (NIR) region and a significant photothermal effect when irradiated with a λ = 808 nm laser diode module.
ChemInform Abstract: Hemisynthesis of Some Biogenetically Anomalous 17β‐Neoclerodane Diterpenoids. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Standard semiconductor packaging for high-reliability low-cost MEMS applications (2005)

Microelectronic packaging technology has evolved over the years in response to the needs of IC technology. The fundamental purpose of the package is to provide protection for the silicon chip and to provide electrical connection to the circuit board. Major change has been witnessed in packaging and today wafer level packaging technology has further revolutionized the industry. MEMS (Micro Electro Mechanical Systems) technology has created new challenges for packaging that do not exist in standard ICs. However, the fundamental objective of MEMS packaging is the same as traditional ICs, the low cost and reliable presentation of the MEMS chip to the next level interconnect. Inertial MEMS is one of the best examples of the successful commercialization of MEMS technology. The adoption of MEMS accelerometers for automotive airbag applications has created a high volume market that demands the highest reliability at low cost. The suppliers to these markets have responded by exploiting standard semiconductor packaging infrastructures. However, there are special packaging needs for MEMS that cannot be ignored. New applications for inertial MEMS devices are emerging in the consumer space that adds the imperative of small size to the need for reliability and low cost. These trends are not unique to MEMS accelerometers. For any MEMS technology to be successful the packaging must provide the basic reliability and interconnection functions, adding the least possible cost to the product. This paper will discuss the evolution of MEMS packaging in the accelerometer industry and identify the main issues that needed to be addressed to enable the successful commercialization of the technology in the automotive and consumer markets.
Costs Attributable to Arteriovenous Fistula and Arteriovenous Graft Placements in Hemodialysis Patients with Medicare coverage (2019)

This study indicates that costs due to VA are a significant burden on Medicare budgets and on patients. The factors driving access-related utilization and costs merit attention in future research. Both optimizing process of care and discovery innovation may significantly accelerate better stewardship of available healthcare resources.