gebhart/patrepeval huggingface dataset:
2,6-Dimethyleneanthracenyl-4,8-dioxy. High-spin ground state of a disjoint biradical that has no Hueckel NBMO degeneracy (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2,6-Dimethyleneanthracenyl-4,8-dioxy. High-spin ground state of a disjoint biradical that has no Hueckel NBMO degeneracyDavid E. Seeger and Jerome A. BersonCite this: J. Am. Chem. Soc. 1983, 105, 15, 5146–5147Publication Date (Print):July 1, 1983Publication History Published online1 May 2002Published inissue 1 July 1983https://pubs.acs.org/doi/10.1021/ja00353a056https://doi.org/10.1021/ja00353a056research-articleACS PublicationsRequest reuse permissionsArticle Views75Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Symptomatic and Asymptomatic Respiratory Viral Infections in the First Year of Life: Association With Acute Otitis Media Development (2014)

Compared to symptomatic infection, asymptomatic viral infection in infants is associated with young age, male sex, low viral load, specific viruses, and single virus detection. Asymptomatic viral infection did not result in AOM.
Genome Sequencing of Sub-Arctic Mesomycetozoean Sphaeroforma sirkka Strain B5, Performed with the Oxford Nanopore minION and Illumina HiSeq Systems (2018)

The Mesomycetozoea branch near the animal-fungal divergence and are believed to be important to understanding the origins of multicellularity. In 2012, a free-living saprotrophic mesomycetozoean was isolated from the sub-Arctic Bering Sea. A hybrid assembly using Illumina and Nanopore sequences yielded 2,688 contigs with a total length of 125,635,304 bases.
High-Pressure Chemical Looping Reforming Processes: System Analysis for Syngas Generation from Natural Gas and Reducing Tail Gases (2018)

Reforming technologies produce syngas that serves as an important intermediate in the production of fuels and chemicals in the chemical and petrochemical industry. Only recently has reforming technology based on the chemical looping concept been attempted. Most chemical looping studies have been performed under ambient pressure conditions, but most processes that use syngas operate at an elevated pressure. Understanding the effect that pressure has on syngas generation in a chemical looping reactor is essential to the design of the overall system. This study characterizes and compares the effect of pressures on syngas yields under various chemical looping reforming operating conditions. Specifically, in this study, an iron-based oxygen carrier is used for the chemical looping partial oxidation reaction of methane to form syngas. The equilibrium simulation is of direct relevance to process applications, as demonstrated by the methane and metal oxide co-current reactor system, where in previous studies, experimental product yields were shown to be appropriately represented by equilibrium conditions. The results of syngas generation at 1 atm are used in this study as the basis for comparison to those obtained under pressurized conditions. The isothermal syngas generation is first examined qualitatively and quantitatively for pressures ranging from 1 to 30 atm. The adiabatic syngas generation is then examined under autothermal operating conditions. The sensitivity studies are performed to describe the changes in product yields as the temperature and pressure along with steam and CO2 inputs are varied. The results of the analysis illustrate the various competing factors that dictate the high-pressure syngas yield and purity. The study also provides insight into choice of operating conditions that enable thermodynamic syngas yields at higher pressure to be comparable to those at atmospheric pressures.
Electrical Nanowell Diagnostics Sensors for Rapid and Ultrasensitive Detection of Prostate-Specific Antigen (2015)

We demonstrated PSA detection between 0.01 and 1000 ng/ml and detection and quantification of PSA from a 17 patient cohort validated using the Beckman Access system with >95% correlation.
SET-THEORETIC LEARNING FOR DETECTION IN CELL-LESS C-RAN SYSTEMS (2018)

Cloud-radio access network (C-RAN) can enable cell-less operation by connecting distributed remote radio heads (RRHs) via fronthaul links to a powerful central unit. In the conventional C-RAN, baseband signals are forwarded after quantization/compression to the central unit for centralized processing/detection in order to keep the complexity of the RRHs low. However, the limited capacity of the fronthaul is a significant bottleneck that prevents C-RAN from supporting large systems (e.g. massive machine-type communications (mMTC)). We propose a learning-based C-RAN in which the detection is performed locally at each RRH and, in contrast to the conventional C-RAN, only the likelihood information is conveyed to the central unit. To this end, we develop a general set-theoretic learning method for estimating likelihood functions. Our method can be used to extend existing detection methods to the C-RAN setting.
Korkormicins, novel depsipeptide antitumor antibiotics fromMicromonospora sp C39500: Fermentation, precursor directed biosynthesis and biological activities (1995)

Micromonospora sp C39500, isolated in our laboratory from a soil sample, produced a complex of seven novel depsipeptide antitumor antibiotics, designated korkormicins. The major component of the complex, korkormicin A, has a MW of 1452 and a molecular formula of C66H84N16O22. Korkormicin A exhibits potent in vivo antitumor activity against P388 leukemia and M109 lung carcinoma implanted intraperitoneally (ip) in mice, with effective doses of 0.05-0.20 mg kg-1 injection-1, for five or three ip injections, respectively. It is also active against Gram-positive bacteria but inactive against Gram-negative bacteria. The production of korkormicin A was enhanced by 3-fold when 0.1% L-valine was added to the production culture at 48 h. A titer of 401.0 micrograms ml-1 was achieved in the fermenter culture supplemented with 0.1% L-valine.
Hypoxia negatively regulates heparan sulfatase 2 expression in renal cancer cell lines (2011)

Inactivation of von Hippel-Lindau (VHL), a tumor suppressor gene is often associated with clear cell renal cell carcinoma (ccRCC). VHL inactivation leads to multitude of responses including enhanced growth factor signaling such as bFGF2, SDF-1α, and HGF. Here, we have identified a novel VHL-inducible gene, heparan sulfatase 2 (HSulf-2) that attenuates heparan-binding growth factor such as bFGF2 signaling. VHL-mediated HIF-1 alpha degradation was essential to restore HSulf-2 expression. Mechanistically, HSulf-2 negatively regulated vimentin expression and knockdown of vimentin abolished cell migration. This study reveals a novel layer of regulation of heparan-binding growth factor signaling via modulation of heparan sulfate by HSulf-2 in ccRCC.
Development of CAR T cell therapy targeting glypican-3 in liver cancer (2018)

Objective: Glypican-3 (GPC3) is a promising therapeutic targetin hepatocellular carcinoma (HCC). We have generated theHN3 and hYP7 antibodies that recognize the N-lobe and C-lobeof GPC3, respectively. Here, we engineered human T cells thatexpress GPC3-specific chimeric antigen receptors (CARs) andevaluated their potential for the treatment of HCC. Methods: The GPC3-specific CARs (CAR.HN3 and CAR.hYP7) contain a CD3ζ chain and the 4-1BB co-stimulatoryendodomain along with a truncated human epidermal growthfactor receptor (huEGFRt) polypeptide that retains thecetuximab epitope. A set of GPC3-positive liver cancer celllines were engineered to express the firefly luciferase gene.These cells were co-cultured with CAR T cells at various ratiosfor cell killing assays. A bioluminescent luciferase reporterassay was then used to evaluate the cytolytic activity of CART cells. We also evaluated the anti-tumor activity of CAR Tcells in xenograft models via intraperitoneal or orthotopicimplantation of luciferase-expressing HCC cells into NOD/SCID/IL2gnull (NSG) mice. Tumor growth was measured viabioluminescence tumor imaging. Results: CAR.hYP7 cells, which target the C-lobe of GPC3,showed the highest cytolytic activity against GPC3-positiveHCC cells. In HCC intraperitoneal xenograft models,tumor cells preferentially grew on the mouse liver. A singleintraperitoneal treatment with CAR.hYP7 cells exhibitedsustainable antitumor efficacy in mice, and all of the micesurvived more than 9 weeks after CAR T cell treatmentwithout recurrence. The serum levels of alpha-fetoprotein inmice treated with CAR.hYP7 cells were less than 50 ng/mL,the threshold value for HCC diagnosis. Conclusions: GPC3-targeting CAR T cells, in particular CAR.hYP7, are a promising therapeutic intervention for liver cancerthat can be translated to human use. DOI: 10.20892/j.issn.2095-3941.2018.S035
Novice Designers’ Approaches to Justifying User Requirements and Engineering Specifications (2020)

Abstract User requirements and engineering specifications represent important criteria that engineering designers use to define their design problems and evaluate the suitability of their solution concepts. Novice designers frequently develop user requirements and engineering specifications as part of curricular design projects; however, few studies have explored how novice designers justify the user requirements and engineering specifications that they develop. This preliminary study analyzed the design reports of capstone design teams to determine how novice designer participants justified their user requirements and engineering specifications. Teams frequently used “Sponsor interactions” and “Perceptions of user needs” as justifications for user requirements but gathered limited data directly from users. As such, the user requirements developed by teams may have been based on team assumptions rather than actual user needs. Teams frequently used “Sponsor interactions,” “Technical research,” and “Prior work” as justifications for engineering specifications. However, teams also developed several engineering specifications without clear justifications. Our findings suggest that as novice designers develop their design skills, they may need scaffolding and support tools to guide the development of user requirements and engineering specifications that accurately reflect user needs.
Impact of Lithium Salt Addition to Ionic Liquid Electrolytes for High-performance Electric Double-layer Capacitors (2013)

The charge-discharge behavior of electric double-layer capacitors (EDLCs) composed of several ionic liquids and their lithium solutions were evaluated. The model EDLC cell with a Li+-containing ionic liquid electrolyte, LiTFSI/EMImFSI (LiTFSI = lithium bis(trifluoromethylsulfonyl)imide, EMImFSI = 1-ethyl-3-methylimidazolium bis(fluorosulfonyl)imide), exhibited a higher discharge capacitance than the cell containing EMImFSI, whereas the discharge capacitance of the cell with LiTFSI/EMImTFSI was lower than that of the cell containing EMImTFSI. In addition, the cells composed of EMImBF4-based electrolytes displayed similar charge-discharge characteristics irrespective of the presence of the corresponding lithium salts. The distinctive results for the EDLCs with lithium-containing ionic liquid electrolytes are also discussed based on the application of the electrochemical impedance technique to model carbon electrodes in ionic liquids. According to the obtained differential capacitance of the model glassy carbon electrode in each ionic liquid electrolyte, the electric double-layer (compact layer) structure at the electrode/electrolyte interface depends on the component anion species of the ionic liquid and the co-existence of the anion and Li+.
Selective Excitation of Concomitant Electrochemiluminophores: Tuning Emission Color by Electrode Potential (2012)

ECL in 3D: Selective electrogenerated chemiluminescence (ECL) of several ruthenium and iridium complexes simultaneously in solution can be controlled by electrode potential (see picture; λem=emission wavelength). These luminescent redox systems create a range of new possibilities for multi-analyte ECL detection, assessment of interdependent electrochemical/spectroscopic properties, and color tuning in light-emitting devices. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Novel heat dissipation approach for high-powered miniature robots (2001)

Bringing instruments capable of atomic scale operations in the form of miniature wireless robots yields very high-density powered electronics. As the robots are further miniaturized, the surface area available for heat dissipation becomes inadequate to maintain continuous operation of the onboard electronics. Typical approaches such as increasing the surface area by mounting a heat sink is not an option since it would increase substantially the overall size of the robot. The overall size has to be minimized to allow a larger fleet of miniature robots to operate simultaneously in the same area. A larger fleet translates to higher throughput for mass-scale atomic-level operations. To solve this issue, we have implemented a special skin in contact with the high-powered flexible electronic circuit surrounding the robot's body. The skin effectively dissipate heat by evaporating distilled water stored in a few layers of flexible patterned wiping fabric designed for maximum water absorption and encapsulated between an inner thin layer of thermally conductive elastometer and an outer thin layer of an heat conducting metal sheet. Without the skin, past experiments have shown that each robot would operate for approximately 10 seconds before shutting down. With a 1-mm thick skin on a 32-mm diameter size robot, experimental results have shown that each robot could operate up to approximately 5 minutes between refills. A thicker water absorption layer is not a valid option since it would increase the overall size of the robot. A refill methodology suitable for this environment is also described.
Comprehensive characterization of toxins during progression of inhalation anthrax in a non-human primate model (2022)

Inhalation anthrax has three clinical stages: early-prodromal, intermediate-progressive, and late-fulminant. We report the comprehensive characterization of anthrax toxins, including total protective antigen (PA), total lethal factor (LF), total edema factor (EF), and their toxin complexes, lethal toxin and edema toxin in plasma, during the course of inhalation anthrax in 23 cynomolgus macaques. The toxin kinetics were predominantly triphasic with an early rise (phase-1), a plateau/decline (phase-2), and a final rapid rise (phase-3). Eleven animals had shorter survival times, mean±standard deviation of 58.7±7.6 hours (fast progression), 11 animals had longer survival times, 113±34.4 hours (slow progression), and one animal survived. Median (lower-upper quartile) LF levels at the end-of-phase-1 were significantly higher in animals with fast progression [138 (54.9-326) ng/mL], than in those with slow progression [23.8 (15.6-26.3) ng/mL] (p = 0.0002), and the survivor (11.1 ng/mL). The differences were also observed for other toxins and bacteremia. Animals with slow progression had an extended phase-2 plateau, with low variability of LF levels across all time points and animals. Characterization of phase-2 toxin levels defined upper thresholds; critical levels for exiting phase-2 and entering the critical phase-3, 342 ng/mL (PA), 35.8 ng/mL (LF), and 1.10 ng/mL (EF). The thresholds were exceeded earlier in animals with fast progression (38.5±7.4 hours) and later in animals with slow progression (78.7±15.2 hours). Once the threshold was passed, toxin levels rose rapidly in both groups to the terminal stage. The time from threshold to terminal was rapid and similar; 20.8±7.4 hours for fast and 19.9±7.5 hours for slow progression. The three toxemic phases were aligned with the three clinical stages of anthrax for fast and slow progression which showed that anthrax progression is toxin- rather than time-dependent. This first comprehensive evaluation of anthrax toxins provides new insights into disease progression.
Vibration-Induced Changes in the Contact Resistance of High Power Electrical Connectors for Hybrid Vehicles (2011)

Relatively little is known about the fretting mechanism of high power connectors used in hybrid vehicles, even though the vehicles are widely being introduced to the market. This paper experimentally investigates the fretting mechanisms of silver-plated high power connectors caused by vibrations. In order to emulate operational and environmental effects, a test stand was designed that is capable of measuring electrical contact resistance (ECR), relative displacement and connector temperature. The experimental results show that the variation of ECR of connectors subject to vibration is primarily due to periodic changes of contact area caused by relative motion between the contact interfaces, rather than other fretting corrosions. This finding was reinforced by observing a good correlation between relative motion and the increase of ECR under vibration. When a vibration stops, the ECR decreased to a value that is slightly larger than the original value. A surface analysis shows no obvious corrosion until the coating is worn away. In addition, the effect of high current on the fretting mechanism is also investigated.
On-chip supply power measurement and waveform reconstruction in a 28nm FD-SOI processor SoC (2016)

A compact system for on-chip supply current wave-form reconstruction and power estimation is presented. The system, comprising a programmable current load, a sampling comparator and processing logic, is implemented in a 28nm FD-SOI system-on-chip (SoC) to monitor the supply of a digital processor generated by a switched-capacitor DC-DC converter. The monitoring system is able to reconstruct the rippling supply waveform and extract core power consumption with a low area overhead (0.3% of the die area). Two different techniques yield either 2.5% accuracy with a 28 ms sample time or 5% accuracy with a 1 μs sample time, providing valuable information for on-chip power management strategies.
Interfacial Kinetic and Binding Properties of the Complete Set of Human and Mouse Groups I, II, V, X, and XII Secreted Phospholipases A2 (2002)

Expression of the full set of human and mouse groups I, II, V, X, and XII secreted phospholipases A(2) (sPLA(2)s) in Escherichia coli and insect cells has provided pure recombinant enzymes for detailed comparative interfacial kinetic and binding studies. The set of mammalian sPLA(2)s display dramatically different sensitivity to dithiothreitol. The specific activity for the hydrolysis of vesicles of differing phospholipid composition by these enzymes varies by up to 4 orders of magnitude, and yet all enzymes display similar catalytic site specificity toward phospholipids with different polar head groups. Discrimination between sn-2 polyunsaturated versus saturated fatty acyl chains is <6-fold. These enzymes display apparent dissociation constants for activation by calcium in the 1-225 microm range, depending on the phospholipid substrate. Analysis of the inhibition by a set of 12 active site-directed, competitive inhibitors reveals a large variation in the potency among the mammalian sPLA(2)s, with Me-Indoxam being the most generally potent sPLA(2) inhibitor. A dramatic correlation exists between the ability of the sPLA(2)s to hydrolyze phosphatidylcholine-rich vesicles efficiently in vitro and the ability to release arachidonic acid when added exogenously to mammalian cells; the group V and X sPLA(2)s are uniquely efficient in this regard.
Surface Morphology-Enhanced Delivery of Bioinspired Eco-Friendly Microcapsules (2022)

We report the development of novel mineralized protein microcapsules to address critical challenges in the environmental impact and performance of consumer, pharmaceutical, agrochemical, cosmetic, and paint products. We designed environment-friendly capsules composed of proteins and biominerals as an alternative to solid microplastic particles or core-shell capsules made of nonbiodegradable synthetic polymeric resins. We synthesized mineralized capsule surface morphologies to mimic the features of natural pollens, which dramatically improved the deposition of high value-added fragrance chemicals on target substrates in realistic application conditions. A mechanistic model accurately captures the observed enhanced deposition behavior and shows how surface features generate an adhesive torque that resists shear detachment. Mineralized protein capsule performance is shown to depend both on material selection that determines van der Waals attraction and on capsule-substrate energy landscapes as parameterized by a geometric taxonomy for surface morphologies. These findings have broad implications for engineering multifunctional environmentally friendly delivery systems.