gebhart/patrepeval huggingface dataset:
349 Locally Recurrent GBM Treated with Resection and Immediate Initiation of Radiation Therapy: Results from a Prospective Trial (2022)

INTRODUCTION: Treatment for recurrent GBM remains problematic. Resection (R) alone is insufficient, and survivals achieved with systemic therapy with or without radiation therapy (RT) are typically &lt;1 year. METHODS: From 2/2013-2/2018, locally recurrent GBM were treated in a single arm trial (ClinicalTrials.gov, NCT#03088579) of R plus implantation of a surgically targeted radiation therapy (STaRT) device utilizing Cs-131 in bioresorbable collagen tiles (GammaTile, GT Medical Technologies, Tempe AZ USA). RESULTS: 28 patients (pts) were treated, 20 at first recurrence (range 1-3). Median age 58 (range 21-80), KPS 80 (60-100), female:male ratio 10:18. Median OS 10.7 mo., radiographic LC 8.8 mo., and no first failure was local. MGMT, KPS, and sex were non-predictive. Post hoc analysis disclosed after R+STaRT, 17 pts (54%) received &gt;1 cycle of systemic (Sys) treatment (“Sys+”) and 13 pts (46%) did not (“Sys- “). Sys was given as adjuvant, salvage, or both, either alone or in combination. 15 pts received bevacizumab (BEV), 12 temozolomide (TMZ) and 8 lomustine (CCNU). Median OS (mo.) for Sys+ vs. Sys- was 15.1/6.5 (hazard ratio (HR) .38, p = .017); OS for BEV+ vs. BEV- was 16.7/4.5 (HR .38, p = .017), TMZ+ vs. TMZ- 17.5/6.7 (HR .40, p = .025) and for CCNU+ vs. CCNU- 17.5/7.9 (HR .61, p = .25), respectively. LC was 11.4 mo. for Sys+ vs. 2.1 mo. for Sys- (HR .44; p = .16). Three attributed serious AE occurred, 1 wound infection requiring surgery and 2 radiation brain effects, managed medically. CONCLUSION: Post hoc analysis suggests R+STaRT+Sys may have the potential to impact OS in locally recurrent GBM, possibly by allowing sufficient time for biologically slower but effective treatments to have an impact.
To Share Or Not To Share (2007)

Intuitively, aggressive work sharing among concurrent queries in a database system should always improve performance by eliminating redundant computation or data accesses. We show that, contrary to common intuition, this is not always the case in practice, especially in the highly parallel world of chip multiprocessors. As the number of cores in the system increases, a trade-off appears between exploiting work sharing opportunities and the available parallelism. To resolve the trade-off, we develop an analytical approach that predicts the effect of work sharing in multi-core systems. Database systems can use the model to determine, statically or at runtime, whether work sharing is beneficial and apply it only when appropriate. The contributions of this paper are as follows. First, we introduce and analyze the effects of the trade-off between work sharing and parallelism on database systems running complex decision-support queries. Second, we propose an intuitive and simple model that can evaluate the trade-off using real-world measurement approximations of the query execution processes. Furthermore, we integrate the model into a prototype database execution engine, and demonstrate that selective work sharing according to the model outperforms never-share static schemes by 20% on average and always-share ones by 2.5x.
1H‐Pyrazolo‐[3,4‐c]cyclophepta[1,2‐c]thiophenes: A Unique Structural Class of Dopamine D4 Selective Ligands. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
ChemInform Abstract: Coupling Reactions. Part 18. Synthesis of Triafulvalene Precursors by “Carbene‐Dimerization” of 1‐Halogeno‐1‐lithiocyclopropanes. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Geminate Charge Recombination in Alternating Polyfluorene Copolymer/Fullerene Blends (2007)

By measuring excited state and charge dynamics in blends of an alternating polyfluorene copolymer and fullerene derivative over nine orders in time and two orders in light intensity, we have monitored the light-induced processes from ultrafast charge photogeneration to much slower decay of charges by recombination. We find that at low light intensities relevant to solar cell operation relatively fast (approximately 30 ns) geminate recombination is the dominating charge decay process, while nongeminate recombination has a negligible contribution. The conclusion of our work is that under solar illumination conditions geminate recombination of charges may be directly competing with efficient charge collection in polymer/fullerene solar cells.
Neuropeptides and Inflammation: The Role of Substance P (1989)

The neuropeptide substance P modulates the activities of a number of different leukocytes that characterize both acute and delayed inflammatory responses. Substance P may play a role in the pathogenesis of such diverse diseases as arthritis, asthma, and inflammatory bowel disease.
μOCT imaging using depth of focus extension by self-imaging wavefront division in a common-path fiber optic probe (2016)

Optical coherence tomography (OCT) is an attractive medical modality due to its ability to acquire high-resolution, cross-sectional images inside the body using flexible, small-diameter, scanning fiber optic probes. Conventional, cross-sectional OCT imaging technologies have approximately 10-μm axial resolution and 30-μm lateral resolution, specifications that enable the visualization of microscopic architectural morphology. While this resolution is useful for many clinical applications, it is insufficient for resolving individual cells that characterize many diseases. To address this gap, a supercontinuum-laser-based, μm-resolution OCT (μOCT) system and a 500 μm-diameter, extended depth of focus single fiber optic probe for endoscopic and intravascular imaging were designed and fabricated. At the distal tip of the fiber optic probe, a cylindrical waveguide was used to divide the wavefront to provide multiple circular propagation modes. Once transmitted through a relatively high NA lens (NA >0.1), these modes were projected as multiple coaxial foci (~3 μm full width at half maximum (FWHM)) over a greatly extended focal depth range. The distal tip of the probe also contained a common-path reference reflectance to minimize polarization and dispersion imbalances between sample and reference arm light. Measurements showed that the probe provides a 20-fold depth of focus extension, maintaining a 3-5 µm lateral resolution (FWHM of PSF) and a 2 μm axial resolution over a depth range of approximately 1 mm. These results suggest that this new optical configuration will be useful for achieving high-resolution, cross-sectional OCT imaging in catheter/endoscope-based medical imaging devices.
Efficient Preparations of Fluorine Compounds. Herausgegeben von Herbert W. Roesky. (2013)

John Wiley & Sons, Hoboken, 2012. 480 S., geb., 109.00 €.—ISBN 978-1118078563
Investigating risk factors for psychological morbidity three months after intensive care: a prospective cohort study (2012)

Strikingly high rates of psychological morbidity were found in this cohort of intensive care survivors. The study's key finding was that acute psychological reactions in the ICU were the strongest modifiable risk factors for developing mental illness in the future. The observation that use of different ICU drugs correlated with different psychological outcomes merits further investigation. These findings suggest that psychological interventions, along with pharmacological modifications, could help reduce poor outcomes, including PTSD, after intensive care.
Synthesis of Substituted 6,7-Dihydro-5H-pyrrolo[2,3-c]pyridazines/pyrazines via Catalyst-Free Tandem Hydroamination–Aromatic Substitution (2020)

Herein, we report an efficient and operationally simple synthesis of 6,7-dihydro-5<i>H</i>-pyrrolo[2,3-<i>c</i>]pyridazines and 6,7-dihydro-5<i>H</i>-pyrrolo[2,3-<i>b</i>]pyrazines via a tandem hydroamination-S<sub>N</sub>Ar sequence that makes use of mild reagents under catalyst-free conditions in moderate to high yields. This chemistry expands the known scope of pyridazine/pyrazine chemistry and can be applied toward the synthesis of novel drug-like molecules with favorable bioactivity and pharmacokinetic properties.
NKp30-dependent cytolysis of filovirus-infected human dendritic cells (2006)

Understanding how protective innate immune responses are generated is crucial to defeating highly lethal emerging pathogens. Accumulating evidence suggests that potent innate immune responses are tightly linked to control of Ebola and Marburg filoviral infections. Here, we report that unlike authentic or inactivated Ebola and Marburg, filovirus-derived virus-like particles directly activated human natural killer (NK) cells in vitro, evidenced by pro-inflammatory cytokine production and enhanced cytolysis of permissive target cells. Further, we observed perforin- and CD95L-mediated cytolysis of filovirus-infected human dendritic cells (DCs), primary targets of filovirus infection, by autologous NK cells. Gene expression knock-down studies directly linked NK cell lysis of infected DCs to upregulation of the natural cytotoxicity receptor, NKp30. These results are the first to propose a role for NK cells in the clearance of infected DCs and the potential involvement of NKp30-mediated cytolysis in control of viral infection in vivo. Further elucidation of the biology of NK cell activation, specifically natural cytotoxicity receptors like NKp30 and NKp46, promises to aid our understanding of microbial pathology.
PIC based FBG Interrogator Designed for High Accuracy and Low Noise Seismic and Dynamic Measurements (2021)

We propose and demonstrate using photonic integrated circuit (PIC) technology, a tunable-laser based FBG interrogator suitable for low noise seismic applications sampling at kHz rates and delivering &lt;120dB re(nm 2 /Hz) noise floor over a 500Hz bandwidth.
Efficacy of Thrombolytic Therapy in Pulmonary Embolism Determined by MION-enhanced MRA (1998)

It was feasible to diagnose pulmonary embolism accurately in this experimental study and to monitor thrombolysis of pulmonary emboli by MION-enhanced magnetic resonance angiography.
Prototype CO_2 laser-induced long-period fiber grating variable optical attenuators and optical tunable filters (2004)

Prototype devices capable of variable attenuation at a fixed wavelength, wavelength tuning at a constant attenuation, and combinations of these spectral characteristics are demonstrated in CO2 laser-induced long-period fiber gratings (LPFGs). These devices are based on controlled flexure by means of a piezoceramic platform. CO2 laser-induced LPFG characteristics along with the fabrication and testing processes of these gratings are discussed. Devices with a optical attenuation of 13 dB and a wavelength tuning of 7 nm are reported.
Inverse regulation of melanoma growth and migration by Orai1/STIM2‐dependent calcium entry (2014)

Spontaneous melanoma phenotype switching is controlled by unknown environmental factors and may determine melanoma outcome and responsiveness to anticancer therapy. We show that Orai1 and STIM2 are highly expressed and control store-operated Ca(2+) entry in human melanoma. Lower extracellular Ca(2+) or silencing of Orai1/STIM2 caused a decrease in intracellular Ca(2+) , which correlated with enhanced proliferation and increased expression of microphthalmia-associated transcription factor, a marker for proliferative melanoma phenotype. In contrast, the invasive and migratory potential of melanoma cells was reduced upon silencing of Orai1 and/or STIM2. Accordingly, markers for a non-proliferative, tumor-maintaining phenotype such as JARID1B and Brn2 decreased. Immunohistochemical staining of primary melanomas and lymph node metastases revealed a heterogeneous distribution of Orai1 and STIM2 with elevated expression in the invasive rim of the tumor. In summary, our results support a dynamic model in which Orai1 and STIM2 inversely control melanoma growth and invasion. Pharmacological tuning of Orai1 and particularly STIM2 might thus prevent metastatic spread and render melanomas more susceptible to conventional therapy.
A disposable magnetic planar peristaltic pump for selfcontained lab-on-a-chip (LOC) cartridge (2007)

We demonstrate a disposable magnetic planar peristaltic pump for LOC applications. The planar feature of the pump allows for its direct integration with a microfluidic chip, producing a compact and low-cost cartridge that does not need any external pump.
Direct Synthesis of Non-Stoichometric Nanocrystalline Metal Oxides and Their Composites: Improving the Reversibility and Current Capability of Lithium-Ion Batteries (2015)

As the demand for large scale batteries grows, considerations such as earth abundance, cost, and toxicity gain increased significance. Metal oxides are worthy of evaluation as active materials for electrochemical energy storage, particularly those utilizing earth abundant, low cost, environmentally benign metal centers. However, to facilitate broader implementation of metal oxides in batteries, improvements to current capability and reversibility are needed. Some metal oxides adopt close-packed coordination environments, which optimize ion density. However, ion and electron transfer are challenges which may or may not be exacerbated as a result of high ion density. An emerging paradigm for the implementation of close-packed materials in higher current applications is the tuning of the materials crystallite dimensions, where the reduction of crystallite size should minimize the path length for ion transport upon discharge, resulting in a reduction of both internal cell resistance and the resultant structural strain associated with lithium insertion. Significant improvements in current capability of metal oxides and their composites via direct crystallite size control and other strategies will be described. The synthetic approaches described in this presentation will provide new strategies which may be applicable toward development of other new classes of materials and composites with energy or energy storage applications.
CD34 + stem cell treatment for acute ischemic stroke (678.20) (2014)

Stroke is the most common cause of significant acquired disability in adults for which only limited therapeutic strategies exist, limited by a brief therapeutic window (&lt;4 h). No pharmacological compound to date has been found to increase recovery reliably once brain injury has occurred. Stem cell transplantation techniques offer novel approaches that may enhance endogenous repair mechanisms, promote brain recovery and regeneration, and may ultimately reduce neurological deficits in stroke patients. While showing positive results, current stem cell therapies are highly inefficient, with a tiny percentage of injected cells arriving at the intended injured site. Following on from our previous open label phase 1 study in stroke patients, to determine the safety and feasibility of treatment with immunoselected CD34+, we have used a murine model of ischemic stroke (the middle cerebral artery occlusion model) to investigate the migration of CD34+ stem cells to the infarcted area. Using both intravital and confocal intravital microscopy we have been able to explore both leukocyte and stem cell trafficking in the murine brain pre and post stroke. Both leukocyte rolling and adherence were increased in mice subjected to stroke vs. sham mice. Stem cell treatment reduced these leukocyte interactions, with effects observed upto two weeks post stroke. These novel data suggest a therapeutic potential role for the use of CD34+ stem cells for acute ischemic stroke
Complex Autoregressive Modelling Of The Cardiac Doppler Signal (2005)

spectrogram obtained by complex (AR) modelling was investigated using -the Yule-Walker equations. The spectral envelope area (SEA) was used to evaluate the effect of window duration on AR spectrogram, and a statistical analysis indicated that the SEA was not sensitive to window duration. The white-noise like behavior of the modelling error indicates that the Doppler blood flow signal can be modelled adequately as a complex AR process.
Energy-efficient and metastability-immune timing-error detection and recovery circuits for dynamic variation tolerance (2008)

Timing-error detection and recovery circuits are implemented in a 65 nm resilient circuit test-chip to eliminate the clock frequency guardband from dynamic supply voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CC</sub> ) and temperature variations as well as to exploit path-activation probabilities for maximizing throughput. Two error-detection sequential (EDS) circuits are introduced to preserve the timing-error detection capability of previous EDS designs while lowering clock energy and removing datapath metastability. Error-recovery circuits replay failing instructions at lower clock frequency to guarantee correct functionality. Relative to conventional circuits, silicon measurements indicate that resilient circuits enable either 25 to 32% throughput gain at equal V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CC</sub> or at least 17% VCC reduction at equal throughput, resulting in 31 to 37% total power reduction.
Material jetting high quality components via an inverse problem framework (2023)

Material jetting is a key additive manufacturing technology to enable the production of microscale components, but its application is limited by susceptibility to deviations from intended design and performance. The main challenge remains in producing accurate and functional parts in a reproducible and timely manner, particularly for fine featured geometries. Existing frameworks to mitigate part deviations are based on computationally expensive physics-based simulations, but little attention has been paid to techniques suitable for high-throughput conditions. Here we develop and validate an inverse problem framework which facilitates predicting the morphology of printed features with a Shape from Shading (SFS) photometric technique coupled with the rapid optimisation of process parameters to enhance the quality of the product. The framework incorporates the critical printing parameters including drop spacing, printing frequency and standoff distance such that we are able to build the morphology of complex patterns with an error percentage less than 10 % in seconds. The inverse problem framework is highly versatile since it can be utilized in conjunction with computer vision algorithms for accurate in-situ inspection of printed features and to find the optimal printing parameters for freeform patterns considering different materials and substrates or even other AM technologies to improve the quality of printed parts in a timely manner.
A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human (2014)

Here, we report on a first-in-man trial where the tuberculosis (TB) vaccine Ag85B-ESAT-6 (H1) was adjuvanted with escalating doses of a novel liposome adjuvant CAF01. On their own, protein antigens cannot sufficiently induce immune responses in humans, and require the addition of an adjuvant system to ensure appropriate delivery and concomitant immune activation. To date no approved adjuvants are available for induction of cellular immunity, which seems essential for a number of vaccines, including vaccines against TB. We vaccinated four groups of human volunteers: a non-adjuvanted H1 group, followed by three groups with escalating doses of CAF01-adjuvanted H1 vaccine. All subjects were vaccinated at 0 and 8 weeks and followed up for 150 weeks. Vaccination did not cause local or systemic adverse effects besides transient soreness at the injection site. Two vaccinations elicited strong antigen-specific T-cell responses which persisted after 150 weeks follow-up, indicating the induction of a long-lasting memory response in the vaccine recipients. These results show that CAF01 is a safe and tolerable, Th1-inducing adjuvant for human TB vaccination trials and for vaccination studies in general where cellular immunity is required.
Infrequent p53 gene mutations in medulloblastomas. (1991)

Cytogenetic and molecular studies of medulloblastomas have demonstrated frequent loss of sequences from the short arm of chromosome 17, possibly implicating loss or inactivation of the p53 tumor suppressor gene. We amplified exons 5 through 8 of the p53 gene by the polymerase chain reaction technique. These segments, which encompass the regions usually mutated in human tumors, were sequenced to search for p53 mutations in 12 medulloblastoma tumors, 8 xenografts, and 3 permanent cell lines. Mutation of the p53 gene was found in only 1 of 3 cell lines tested and in none of the xenografts or primary tumors studied. Our results suggest that p53 is mutated in an unusual way or that a second tumor suppressor gene on the short arm of chromosome 17 is involved in the pathogenesis of medulloblastoma.
Function of Periecan Domain 1 in Prostate Cancer (2006)

Preferential metastasis of prostate cancer (PCa) to bone marrow contributes to disease mortality and morbidity. Local factors present in the bone stromal extracellular matrix (ECM) increase metastatic tumor growth through paracrine interactions among tumor, stromal and endothelial cells present in the microenvironment. Heparin binding growth factors (HBGF) present in bone marrow provide growth and survival signals to metastatic PCa cells. Perlecan (Pln), the major heparan sulfate proteoglycan (HSPG) in the bone marrow stromal ECM functions as a co-receptor to deliver HBGFs to high affinity receptors. HSchains on Pln are located in a unique N-terminal domain I (PlnDI) which serves as a co-receptor for HBGFs. We hypothesized that Pln, specifically PlnDI, delivers HBGFs to the PCa cell surface, promotes cell survival and protects from apoptosis. We used three PCa cell lines: LNCaP, C4-2B, and PC3 to study the function of PlnDI. We harvested conditioned medium (CM) from bone stromal cell lines, HS27a and HS5, which produce abundant Pln. The proteoglycan rich fraction containing Pln was obtained using anion exchange bead chromatography, then tested as a survival factor for the three different PCacell lines. DNA fragmentation experiments showed that bone stromal derived Pln from CM protected all three lines of PCa cells from camptothecin induced apoptosis. We also supplied purified, fully glycosylated recombinant PlnDI protein to PCa cells, which also protected cells from apoptosis. Pln knockdown clones grow poorly compared to the parental or control transfected C4-2B cells (Ref.1).Interestingly, knockdown cells weremore susceptible to apoptosis in response to the apoptosis inducers anti-Fas and camptothecin, and exogenous PlnDI rescued survival. We followed this up by undertaking to identify natural factor(s) produced by bone marrow stromal cells that induces apoptosis in PCa cells. We found that this apoptosis inducing activity is specific for LNCaP derived lines.
Device Performance of Emerging Photovoltaic Materials (Version 2) (2021)

Following the 1 release of the “Emerging PV reports” , the best achievements in the performance of emerging photovoltaic devices in diverse emerging photovoltaic research subjects are summarized, as reported in peer-reviewed articles in academic journals since August 2020. Updated graphs, tables and analyses are provided with several performance parameters, e.g. power conversion efficiency, open-circuit voltage, short-circuit current density, fill factor, light utilization efficiency, and stability test energy yield. These parameters are presented as a function of the photovoltaic bandgap energy and the average visible transmittance for each technology and application, and are put into perspective using, e.g., the detailed balance efficiency limit. The 2 instalment of the “Emerging PV reports” extends the scope towards tandem solar cells and presents the current state of the art in tandem solar cell performance for various material combinations.