gebhart/patrepeval huggingface dataset:
Differential expression of the normal and of the translocated human c-myc oncogenes in B cells. (1983)

We have investigated whether the translocated and the untranslocated human c-myc oncogenes of Burkitt lymphoma cells are equally or differentially expressed in host mouse B cells. The human c-myc mRNA levels in somatic cell hybrids between mouse plasmacytoma cells and Burkitt lymphoma cells with either the t(8;14) or the t(2;8) chromosome translocation were determined by using the nuclease S1 protection procedure. Although both the human parental lines and the hybrid cells carrying the translocated c-muc oncogene expressed high levels of human specific c-myc transcripts, the hybrid cells carrying the untranslocated c-myc gene on normal chromosome 8 did not contain human specific c-myc mRNA. These results suggest that the translocated human c-myc oncogene has escaped the normal transcriptional control to which the untranslocated c-myc gene remains subjected. This interpretation is also supported by the finding that the expression of the c-myc genes of lymphoblastoid cells and of HL-60 promyelocytic leukemia cells are repressed when they are transferred into a mouse plasmacytoma background. The ability of the translocated c-myc oncogene to escape the normal transcriptional control occurring in B cells may be important for the expression of B cell neoplasia in mouse and man. We have also transferred the Burkitt 14q+ chromosome carrying a translocated c-myc oncogene into mouse LM-TK- fibroblasts and studied the levels of human c-myc transcripts in the hybrids. Because the levels of human c-myc transcripts in the fibroblast hybrids are dramatically decreased in comparison to the plasmacytoma hybrids, we conclude that the levels of transcripts of the translocated c-myc oncogene depend on the differentiated state of the cells harboring the translocated chromosome.
A linearized framework and a new benchmark for model selection for\n fine-tuning (2021)

Fine-tuning from a collection of models pre-trained on different domains (a\n"model zoo") is emerging as a technique to improve test accuracy in the\nlow-data regime. However, model selection, i.e. how to pre-select the right\nmodel to fine-tune from a model zoo without performing any training, remains an\nopen topic. We use a linearized framework to approximate fine-tuning, and\nintroduce two new baselines for model selection -- Label-Gradient and\nLabel-Feature Correlation. Since all model selection algorithms in the\nliterature have been tested on different use-cases and never compared directly,\nwe introduce a new comprehensive benchmark for model selection comprising of:\ni) A model zoo of single and multi-domain models, and ii) Many target tasks.\nOur benchmark highlights accuracy gain with model zoo compared to fine-tuning\nImagenet models. We show our model selection baseline can select optimal models\nto fine-tune in few selections and has the highest ranking correlation to\nfine-tuning accuracy compared to existing algorithms.\n
Introduction of the Harmonic Distortion Determining Factor and Its Application to Evaluating Real Time PWM Inverters (1995)

Frequency spectra of inverter output currents are one of the important factors in order to evaluate PWM methods. These spectra are, however, influenced not only by the PWM method itself but by the operating conditions of the inverter such as the switching frequency or load parameters. The harmonic distortion determining factor (HDDF) is considered to be a common quality index that represents the intrinsic spectral property of individual PWM methods. As it has a close relation to RMS values of the harmonic current or torque ripples of driven motors and, further, it is almost independent of the operating conditions, HDDF is quite useful for evaluating PWM methods. In this paper three typical analog PWM methods and four digital PWM methods are compared and evaluated based on HDDF values.
Standing Waves Induced by Valley-Mismatched Domains in Ferroelectric SnTe Monolayers (2019)

Two-dimensional (2D) quasiparticle standing waves originate from the interference of coherent quantum states and are usually created by the scattering off edges, atomic steps, or adatoms that induce large potential barriers. We report standing waves close to the valence band maximum (E_{V}), confined by electrically neutral domain walls of newly discovered ferroelectric SnTe monolayers, as revealed by spatially resolved scanning tunneling spectroscopy. Ab initio calculations show that this novel confinement arises from the polarization lifted hole valley degeneracy and a ∼90° rotation of the Brillouin zones that render holes' momentum mismatched across neighboring domains. These results show a potential for polarization-tuned valleytronics in 2D ferroelectrics.
Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags (2019)

The cell nucleus is one of the most important organelles as a subcellular drug-delivery target, since modulation of gene replication and expression is effective for treating various diseases. Here, we demonstrate light-triggered nuclear translocation of guests using caged molecular glue (CagedGlue-R) tags, whose multiple guanidinium ion (Gu+) pendants are protected by an anionic photocleavable group (butyrate-substituted nitroveratryloxycarbonyl; BANVOC). Guests tagged with CagedGlue-R are taken up into living cells via endocytosis and remain in endosomes. However, upon photoirradiation, CagedGlue-R is converted into uncaged molecular glue (UncagedGlue-R) carrying multiple Gu+ pendants, which facilitates the endosomal escape and subsequent nuclear translocation of the guests. This method is promising for site-selective nuclear-targeting drug delivery, since the tagged guests can migrate into the cytoplasm followed by the cell nucleus only when photoirradiated. CagedGlue-R tags can deliver macromolecular guests such as quantum dots (QDs) as well as small-molecule guests. CagedGlue-R tags can be uncaged with not only UV light but also two-photon near-infrared (NIR) light, which can deeply penetrate into tissue.
Development of ankylosis in permanent incisors following delayed replantation and severe intrusion (2007)

Ankylosis is a predictable outcome for replanted incisors and for most severely intruded incisors. There is no treatment to arrest or reverse this periodontal ligament complication. Ankylosis of the incisors of preadolescents alters local alveolar growth and eventually produces tooth loss subsequent to resorption. Currently, clinical methods used to diagnose ankylosis in the early postinjury period include subjective assessments of percussion sound and mobility and quantitative devices such as the Periotest. This paper describes the progression of ankylosis in two preadolescent patients that sustained severe trauma to their maxillary central incisors. A number of clinical assessments for diagnosis of ankylosis were compared for their usefulness, reliability and suitability.
Ellipsis and Higher-Order Unification (1995)

We present a new method for characterizing the interpretive possibilities generated by elliptical constructions in natural language. Unlike previous analyses, which postulate ambiguity of interpretation or derivation in the full clause source of the ellipsis, our analysis requires no such hidden ambiguity. Further, the analysis follows relatively directly from an abstract statement of the ellipsis interpretation problem. It predicts correctly a wide range of interactions between ellipsis and other semantic phenomena such as quantifier scope and bound anaphora. Finally, although the analysis itself is stated nonprocedurally, it admits of a direct computational method for generating interpretations.
Renal Metabolism of 111In-DTPA-d-Phe1-Octreotide in Vivo (1998)

The persistent localization of radioactivity in the kidney after administration of 111In-DTPA-D-Phe1-octreotide impairs the diagnostic accuracy of this radiopharmaceutical. To better understand the mechanisms responsible for the renal radioactivity levels of 111In-DTPA-D-Phe1-octreotide, the renal metabolism of this compound was compared with 111In-DTPA-L-Phe1-octreotide, where the N-terminal D-phenylalanine was replaced with L-phenylalanine to facilitate metabolism. DTPA-D-Phe1-octreotide and DTPA-L-Phe1-octreotide were synthesized by solid-phase methods. Both 111In-DTPA-conjugated octreotide analogues were prepared with radiochemical yields of over 96%, and both remained stable after a 3 h incubation in murine serum at 37 degreesC. When injected into mice, the two 111In-DTPA-conjugated octreotide analogues showed similar radioactivity elimination rates from the blood and accumulation in the kidney with about 60% injected radioactivity being excreted in the urine by 24 h postinjection. Over 85% of the radioactivity in the urine existed as intact peptides for both analogues. Despite the similar renal radioactivity levels, significant differences were observed in the radiolabeled species remaining in the kidney between the two; while 111In-DTPA-L-Phe1-octreotide was rapidly metabolized to the final radiometabolite, 111In-DTPA-L-Phe, the metabolic rate of 111In-DTPA-D-Phe1-octreotide was so slow that various intermediate radiolabeled species were observed. However, both 111In-DTPA-D-Phe and 111In-DTPA-L-Phe remained in the lysosomal compartment of the renal cells as the final radiometabolites for long periods. These findings indicated that although the metabolic stability of 111In-DTPA-D-Phe1-octreotide in the renal cells may be partially involved, the slow elimination rate of the radiometabolite derived from 111In-DTPA-D-Phe1-octreotide from the lysosomal compartment of renal cells would be predominantly attributable to the persistent renal radioactivity levels of 111In-DTPA-D-Phe1-octreotide.
Measurement Aided 3G Radio Network Prediction: Fuzzy Bayesian Framework (2007)

We have used measurements taken on real network to enhance the performance of our radio network planning tool. A distribution learning technique is adopted to realize this challenged task. To ensure better generalization capabilities of the learning algorithm, a preprocessing of data is required and involves the use of a clustering algorithm that divides the whole learning space into subspaces. In this paper we apply a new fuzzy clustering algorithm to a prediction tool of a third generation (3G) cellular radio network. Results show that the differences observed between simulations and measurements can be considerably diminished and the generalization capacity is enhanced thanks to the proposed clustering algorithm. This algorithm performs well than classical c-means algorithm. We can then predict with enhanced accuracy new configuration for which we don't have measurements, as long they are not very different from learned configurations.
Ghost imaging at an XUV free-electron laser (2020)

Here we present the results of a classical ghost imaging experiment accomplished at an XUV free-electron laser (FEL). To perform such experiment at an FEL source each x-ray pulse was transmitted through a moving diffuser, which created a noncorrelated speckled beam. This beam was then split in two identical branches by introducing a beam splitter in the form of a transmission grating. In one of these branches the sample was positioned. We demonstrate the possibility of image formation, a double bar in our case, in the beam that has never interacted with the sample. With this experiment we extend the quantum optics methodology to the FEL community.
Intra Prediction by Averaged Template Matching Predictors (2007)

Intra prediction is an effective tool for coding still images and intra pictures in video. The H.264/AVC video compression standard uses extrapolation of the reconstructed pixels surrounding the target block to be coded to form the sample predictor block. Our previous paper augmented this conventional intra prediction method with sample predictor blocks generated using pixel based texture synthesis by template matching methods. This paper describes further improvements and refinements of the sample predictor block creation method. Multiple candidate sample predictor blocks were created using template matching. A weighted average of the multiple candidates then formed the final sample predictor block. Improvements in coding efficiency by more than 15% in bitrates were achieved by this refined method compared to the conventional intra prediction. The impact of the search window and the different template shapes used in the template matching method was also studied and presented.
Incremental ELMVIS for unsupervised learning (2019)

An incremental version of the ELMVIS+ method is proposed in this paper. It iteratively selects a few best fitting data samples from a large pool, and adds them to the model. The method keeps high speed of ELMVIS+ while allowing for much larger possible sample pools due to lower memory requirements. The extension is useful for reaching a better local optimum with greedy optimization of ELMVIS, and the data structure can be specified in semi-supervised optimization. The major new application of incremental ELMVIS is not to visualization, but to a general dataset processing. The method is capable of learning dependencies from non-organized unsupervised data -- either reconstructing a shuffled dataset, or learning dependencies in complex high-dimensional space. The results are interesting and promising, although there is space for improvements.
Differentiated quality of service: slotted ALOHA (2005)

This work shows how the diversity slotted ALOHA multiple access scheme can very simply be extended to offer a premium quality of service to a subset of users. Diversity slotted ALOHA is a generalization of the classic slotted ALOHA in which a user transmits multiple copies of the same message. Premium users obtain a better quality of service by utilizing higher diversity, that is, by transmitting more copies of their messages than basic users.
90-yttrium-ibritumomab tiuxetan as first-line treatment for follicular lymphoma: updated efficacy and safety results at an extended median follow-up of 9.6 years (2022)

Radioimmunotherapy with 90-yttrium-ibritumomab tiuxetan (90Y-IT) as first-line treatment in patients with follicular lymphoma (FL) demonstrated promising results with a complete remission (CR) rate of 56% and a median progression-free survival (PFS) of 26 months, when initially analyzed after a median follow-up of 30.6 months. The aim of this long-term follow-up was to investigate whether clinical benefits were maintained and new safety signals appeared. Fifty-nine patients, aged ≥ 50 years, with FL grade 1 to 3A in stages II to IV were treated with 90Y-IT as first-line therapy. If CR without evidence of minimal residual disease (MRD), partial response or stable disease was achieved 6 months after treatment, patients were observed without further treatment. Patients with CR but persisting MRD received consolidation therapy with rituximab. The primary endpoint was the clinical response rate. Secondary endpoints were time to progression, safety, and tolerability. After a median follow-up of 9.6 years, median PFS was 3.6 years, and 8-year PFS was 38.3%. Median overall survival (OS) was not reached during the extended follow-up, and 8-year OS amounted to 69.2%. Age 65 years and above or disease progression within 24 months of treatment were significantly associated with shorter OS. An important finding was the lack of new safety signals. In particular, no increase in secondary malignancies or transformation into aggressive lymphoma was observed compared to trials with a similar follow-up. In summary, 90Y-IT as first-line treatment demonstrates a favorable safety profile and long-term clinical activity in a substantial fraction of FL patients in need of therapy. ClinicalTrials.gov Identifier: NCT00772655.
Functional antagonists of the Apelin (APJ) receptor (2013)

The recently discovered apelin receptor (APJ, AGTRL-1, APLNR) system has emerged as a critical mediator of cardiovascular homeostasis involved in the pathogenesis of hypertension, heart failure, atherosclerosis and other cardiovascular diseases. Herein is presented the discovery and characterization the first non-peptide based potent (3.7 μM) small molecule APJ functional agonist in cell-based assays, that is >21 fold selective over the closely related angiotensin 1 (AT1) receptor, derived from a high throughput screen (HTS) of the ~330,600 compound Molecular Libraries Small Molecule Repository (MLSMR) collection. This agonist showed some binding activity against 4 out of 37 other GPCRs and transporters, including the 5-HT1A, α2C adrenergic, and benzylpiperazine receptors (55%I, 51%I and 65%I at 10 μM, respectively) and the norepinephrine transporter (57%I at 10 μM). The synthetic methodology, development of structure-activity relationships (SAR), and initial in vitro pharmacologic characterization are also presented. This probe molecule provides a useful tool compound for investigators interested in understanding apelin receptor pharmacology and function.
Commensal bacteria stimulate antitumor responses via T cell cross-reactivity (2020)

Recent studies show gut microbiota modulate antitumor immune responses; one proposed mechanism is cross-reactivity between antigens expressed in commensal bacteria and neoepitopes. We found that T cells targeting an epitope called SVYRYYGL (SVY), expressed in the commensal bacterium Bifidobacterium breve (B. breve), cross-react with a model neoantigen, SIYRYYGL (SIY). Mice lacking B. breve had decreased SVY-reactive T cells compared with B. breve-colonized mice, and the T cell response was transferable by SVY immunization or by cohousing mice without Bifidobacterium with ones colonized with Bifidobacterium. Tumors expressing the model SIY neoantigen also grew faster in mice lacking B. breve compared with Bifidobacterium-colonized animals. B. breve colonization also shaped the SVY-reactive TCR repertoire. Finally, SVY-specific T cells recognized SIY-expressing melanomas in vivo and led to decreased tumor growth and extended survival. Our work demonstrates that commensal bacteria can stimulate antitumor immune responses via cross-reactivity and how bacterial antigens affect the T cell landscape.
Preclinical in vivo long-term evaluation of the novel Mitra-Spacer technology: experimental validation in the ovine model (2017)

In the healthy ovine model, Mitra-Spacer implantation was feasible and safe. At 90 days, no evidence of structural damage to the mitral apparatus or deterioration of cardiac performance was demonstrated.
From 65nm to 28nm Power Amplifiers for 60GHz Applications (2014)

International audience
Enhancement-Mode GaN Transistor Technology for Harsh Environment Operation (2023)

This letter reports an enhancement-mode (E-mode) GaN transistor technology which has been demonstrated to operate in a simulated Venus environment (460 °C, ~ 92 atm., containing CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /SO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> etc.) for 10 days. The robustness of the W/p-GaN-gate AlGaN/GaN high electron mobility transistor (HEMT) was evaluated by two complementary approaches, (1) <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in-situ</i> electrical characterization, which revealed proper transistor operation (including E-mode <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${V}_{\textit {TH}}$ </tex-math></inline-formula> with <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$ &lt; {0}.{09}$ </tex-math></inline-formula> V variation) in extreme environments; and (2) advanced microscopy investigation of the device after test, which highlighted the effect of the stress conditions on the epitaxial and device structures. To the best of the authors’ knowledge, this is the first demonstration and comprehensive analysis of E-mode GaN transistors in such harsh environments, therefore establishing the proposed GaN technology as a strong contender for harsh environment mixed-signal electronics.
Hemodynamic support and the role of dopamine. (1998)

The armamentarium of the critical care nephrologist contains several vasoactive and inotropic drugs with powerful effects on the systemic circulation. The physiologically logical use of these drug can be life-saving and have important beneficial effects on renal function. Such drug use must absolutely not be based on a "fixed dosage," but must instead be goal-directed with the aim of achieving those physiological states associated with hemodynamic stability and adequate vital organ perfusion. The achievement and maintenance of these goals must be prompt and guided by appropriate invasive hemodynamic monitoring and may require frequent changes in dosage. When these measures are adhered to, renal protection and clinical success are a much more likely outcome than when stereotyped approaches are followed.
Robust watermark extraction using SVD-based dynamic stochastic resonance (2011)

In this paper, a novel dynamic stochastic resonance (DSR)-based non-blind watermark extraction technique has been proposed for robust extraction of a grayscale watermark. The watermark embedding has been carried out using singular value decomposition (SVD). Dynamic stochastic resonance has been strategically used to improve the robustness of the extraction algorithm by utilizing the noise added during attacks itself. Resilience of this technique to attacks has been tested in the presence of various noise, geometrical, enhancement, compression and filtering attacks. Using the DSR-based proposed extraction algorithm, a very robust extraction of watermark can be done without trading-off with visual quality of the watermarked image. Performance of the proposed technique has also been compared with the plain SVD-based and hybrid DCT-SVD based technique and is found to give better performance.
ChemInform Abstract: V2O3‐Polymer Composite Thermistors. (1987)

Abstract Composites prepared by incorporation of V 2 O 3 into crystalline and amorphous polymers are found to exhibit large positive temp. coefficient (PTC) and negative temp. coefficient (NTC) of resistance effects over a wide range of filler volume fractions.
Colourless nonlinear optical D-π-A polymers with sulphones as electron acceptors (1990)

Novel colourless side-chain methacrylate copolymers exhibiting relatively narrow charge-transfer bands at 335 nm and second-order optical nonlinearities up to d33= 4.3 pm V–1(at 1064 nm) have been synthesized and characterized.