gebhart/patrepeval huggingface dataset:
CCSW'19 Workshop Summary (2019)

Clouds and massive-scale computing infrastructures are starting to dominate computing and will likely continue to do so for the foreseeable future. Major cloud operators are now comprising millions of cores hosting substantial fractions of corporate and government IT infrastructure. CCSW is the world's premier forum bringing together researchers and practitioners in all security aspects of cloud-centric and outsourced computing. CCSW especially encouraged novel paradigms and controversial ideas that are not on the above list. The workshop has historically acted as a fertile ground for creative debate and interaction in security-sensitive areas of computing impacted by clouds. This year marked the 10th anniversary of CCSW. In the past decade, CCSW has had a significant impact in our research community. As of August 2019, in the Google Scholar Metrics entry for ACM CCS (which encompasses CCSW), 20% of the top 20 cited papers come from CCSW. One way to look at it is that authors are as likely or perhaps more likely to have a top-20 paper publishing in CCSW than in CCS! This year, CCSW received 40 submissions out of which 15 full papers (37%) and 2 blitz abstracts were accepted. CCSW Website: https://ccsw.io
The Physical World as an Abstract Interface (2020)

In the case of tangible user interfaces, this leads us to think of the ways in which the physical world can express an abstract information structure, and an arrangement of physical objects can become notation, perhaps expressed as manipulable solid diagram. The types of information entity envisaged include people, documents, tasks, reminders, timers, and so on. Users will be able to use their interface to “physically” pass information entities between interactive surfaces, and associate tokens with others’ entities to monitor their evolution, e.g. progress on a task. The tokens could be ordered into physical structures that both illustrated and enforced the abstract argumentation structures of classical rhetoric. This process was carried out in teams, where all children could see the emerging abstract structure, and collaborate in constructing and refining it. The positions and identities of tokens are detected using computer vision techniques, and attributes of the associated information entity are dynamically displayed around the token on the interactive surface.
Optimum Design of Hybrid Raman-EDFA System to Maximize Aggregate Capacity (2015)

Optimizing the aggregate capacity in a broad-band system is a challenging task. We review the optimization of a hybrid Raman-EDFA system design and demonstrate a record capacity of 54 Tb/s over 9,150 km.
A Single Electroporation Delivery of a DNA Vaccine Containing the Hemagglutinin Gene of Asian H5N1 Avian Influenza Virus Generated a Protective Antibody Response in Chickens against a North American Virus Strain (2013)

Protection against the avian influenza (AI) H5N1 virus is suspected to be mainly conferred by the presence of antibodies directed against the hemagglutinin (HA) protein of the virus. A single electroporation delivery of 100 or 250 μg of a DNA vaccine construct, pCAG-HA, carrying the HA gene of strain A/Hanoi/30408/2005 (H5N1), in chickens led to the development of anti-HA antibody response in 16 of 17 immunized birds, as measured by a hemagglutination inhibition (HI) test, competitive enzyme-linked immunosorbent assay (cELISA), and an indirect ELISA. Birds vaccinated by electroporation (n = 11) were protected from experimental AI challenge with strain A/chicken/Pennsylvania/1370/1/1983 (H5N2) as judged by low viral load, absence of clinical symptoms, and absence of mortality (n = 11). In contrast, only two out of 10 birds vaccinated with the same vaccine dose (100 or 250 μg) but without electroporation developed antibodies. These birds showed high viral loads and significant morbidity and mortality after the challenge. Seroconversion was reduced in birds electroporated with a low vaccine dose (10 μg), but the antibody-positive birds were protected against virus challenge. Nonelectroporation delivery of a low-dose vaccine did not result in seroconversion, and the birds were as susceptible as those in the control groups that received the control pCAG vector. Electroporation delivery of the DNA vaccine led to enhanced antibody responses and to protection against the AI virus challenge. The HI test, cELISA, or indirect ELISA for anti-H5 antibodies might serve as a good predictor of the potency and efficacy of a DNA immunization strategy against AI in chickens.
Relationship Between Knee Mechanics and Time Since Injury in ACL-Deficient Knees Without Signs of Osteoarthritis (2015)

The results of this study provide an understanding of the relationship between kinematics and kinetics of the ACLD knee and the amount of time since injury. They suggest that elapsed time since injury might be an important factor when the function of ACL-injured knees is interpreted as it relates to osteoarthritis.
Supplementary Tables 1-6 from Sonic Hedgehog and Gli1 Expression Predict Outcome in Resected Pancreatic Adenocarcinoma (2023)

&lt;p&gt;Supplementary Tables 1-6. Table 1 shows the correlation between immunohistochemical factors and clinicopathological data, Table 2: Univariate analyses of patients characteristics and IHC factors to disease-free survival, Table 3: Multivariate analysis for training and validation sets: clinicopathological variables, Table 4: Multivariate Analyses: OS for patients according to the nodal status, Table 5: Interaction between adjuvant therapy and biomarkers, Table 6: Stromal index and patients' outcomes&lt;/p&gt;
Chloroxylenol- and triclosan-tolerant bacteria from industrial sources (2002)

Potential development of bacterial tolerance to biocides in the industrial environment is examined in this study. Bacteria tolerant to the phenolic-type agent para-chloro-meta-xylenol (PCMX) and the bis-phenol 2,4,4′-trichloro-2′-hydroxydiphenylether (triclosan) were isolated from industrial sources and identified. Minimum inhibitory concentrations (MICs) were determined and compared with those of culture collection (standard) strains. Of around 100 isolates originally obtained, most were naturally tolerant species such as Pseudomonas spp., or showed low tolerance levels. PCMX-tolerant isolates of Pseudomonas stutzeri and triclosan-tolerant isolates of Citrobacter freundii and Acinetobacter johnsonii were retained for further study. Of these, only P. stutzeri and A. johnsonii showed elevated tolerance compared with the standard strains. There was no evidence of tolerance to the other biocide except for Pseudomonas aeruginosa (an intrinsically tolerant microorganism), and tolerances were stable in the absence of selective pressure except for A. johnsonii. Attempts to select or generate increased tolerance in the standard strains were unsuccessful. High tolerances in terms of MIC were not reflected in terms of lethal effects. This study did not produce any evidence suggesting that the presence of residual biocide concentrations in the industrial environment promotes the emergence of bacterial tolerance for them.
Separation of track- and shower-like energy deposits in ProtoDUNE-SP using a convolutional neural network (2022)

Abstract Liquid argon time projection chamber detector technology provides high spatial and calorimetric resolutions on the charged particles traversing liquid argon. As a result, the technology has been used in a number of recent neutrino experiments, and is the technology of choice for the Deep Underground Neutrino Experiment (DUNE). In order to perform high precision measurements of neutrinos in the detector, final state particles need to be effectively identified, and their energy accurately reconstructed. This article proposes an algorithm based on a convolutional neural network to perform the classification of energy deposits and reconstructed particles as track-like or arising from electromagnetic cascades. Results from testing the algorithm on experimental data from ProtoDUNE-SP, a prototype of the DUNE far detector, are presented. The network identifies track- and shower-like particles, as well as Michel electrons, with high efficiency. The performance of the algorithm is consistent between experimental data and simulation.
Regulating Prostate Cancer Sensitivity to Chemotherapy through Translational Control of CCAAT Enhancer Binding Proteins (2015)

Abstract : Hyper-activation of the PI3K-AKT-mTOR signaling pathway is frequently observed in advanced prostate cancer and has been suggested to promote survival of prostate cancer cells under androgen deprivation. The transcription factor C/EBP beta is expressed as three different translational isoforms from a single transcript and has been suggested to regulate mTOR activity. The longer LAP isoforms promote cell survival, growth arrest and differentiation whereas the LIP isoform can promote cell proliferation. The purpose of these studies were to evaluate the role of C/EBP beta translational isoforms in prostate cancer resistance to chemotherapy. The 4E/G interaction inhibitor (4E/Gi), which blocks cap-dependent translation, significantly upregulated the LAP isoforms in both PC3 and LNCaP cells. Suppression of C/EBP beta in PC3 cells increased mTOR activity and induction of LAP expression by 4E/Gi and bicalutamide treatment additively suppressed mTOR. We also evaluated the proteasome inhibitor bortezomib as another means to alter C/EBP isoforms, because it can also inhibit cap-dependent translation. Bortezomib increased the LAP:LIP ratio in LNCaP and PC3 cells and suppression of CEBPB sensitized these cells to bortezomib in vitro. PC3 xenografts deficient in CEBPB showed suppressed growth and were also sensitized to bortezomib administration. Our data suggest that CEBPB LAP isoforms suppress AKT-mTOR activity, but may protect prostate cancer cells from bortezomib. Conversely, increasing CEBPB LAP isoform levels by blocking cap-dependent translation may be an effective strategy to prevent transition to castrate-resistant prostate cancer or sensitize prostate cancer cells to mTOR inhibitors by suppressing AKT activity.
Perspective on using multiple orbital-angularmomentum beams for enhanced capacity in freespace optical communication links (2021)

Structured light has gained much interest in increasing communications capacity through the simultaneous transmission of multiple orthogonal beams. This paper gives a perspective on the current state of the art and future challenges, especially with regards to the use of multiple orbital angular momentum modes for system performance enhancement.
Component Based Performance Modelling of Wireless Routing Protocols (2009)

We propose a component based methodology for modelling and design of wireless routing protocols. Componentization is a standard methodology for analysis and synthesis of complex systems, or software. The feasibility of the component based design relies heavily on the compositionality property (i.e. system-level properties can be computed from properties of components). To provide a component based design methodology and to test compositionality for routing protocols, we have to develop a component based model of the wireless network. We present the main components of the routing protocol that should be modelled and focus on three main components: neighborhood discovery, selector of topology information to disseminate, and the path selection components. For each component, we identify the inputs, outputs, and a generic methodology for modelling. Throughout the paper, we use the Optimized Link State Routing (OLSR) protocol as a case study to demonstrate the effectiveness of our approach. Using the neighborhood discovery component, we present our design methodology and design a modified enhanced version of this component, and compare its performance to the original OLSR design.
ChemInform Abstract: Hypercoordinate Compounds of the Group 14 Elements Containing ϰn‐C,N‐, C,O‐, C,S‐ and C,P‐Ligands (2016)

Abstract Review: syntheses as well as investigations of their unique structures and electronic roperties; 115 refs.
11.5 A 512-Pixel 3kHz-Frame-Rate Dual-Shank Lensless Filterless Single-Photon-Avalanche-Diode CMOS Neural Imaging Probe (2019)

Optical functional neural imaging has revolutionized neuroscience with optical reporters that enable single-cell-resolved monitoring of neuronal activity in vivo. State-of-the-art microscopy methods, however, are fundamentally limited in imaging depth by absorption and scattering in tissue even with the use of the most sophisticated two-photon microscopy techniques [1]. To overcome this imaging depth problem, we develop a lens-less, optical-filter-less, shank-based image sensor array that can be inserted into the brain, allowing cellular-resolution recording at arbitrary depths with excitation provided by an external laser light source (Fig. 11.5.1). Lens-less imaging is achieved generally by giving each pixel a spatial sensitivity function, which can be introduced by near-field or far-field, phase or amplitude masking. Since probe thickness must be less than $70 \mu \mathrm {m}$ to limit tissue damage and far-field masks are characterized by distances on the order of $200 \mu \mathrm {m}$ between the mask and the detector [2], we employ a near-field amplitude mask formed by Talbot gratings in the back-end metal of the CMOS process, which gives each pixel a diffraction-grating-induced angle-sensitivity [3]. Filter-less fluorescence imaging is achieved with time-gated operation in which the excitation light source is pulsed and pixel-level time-gated circuitry collects photons only after the excitation source has been removed.
Towards Increased Reliability, Transparency and Accessibility in Crosslinking Mass Spectrometry (2020)

Crosslinking mass spectrometry (Crosslinking MS) has substantially matured as a method over the last two decades through parallel development in multiple labs, demonstrating its applicability for protein structure determination, conformation analysis and mapping protein interactions in complex mixtures. Crosslinking MS has become a much-appreciated and routinely applied tool especially in structural biology. Therefore, it is timely that the community commits to the development of methodological and reporting standards. This white paper builds on an open process comprising a number of events at community conferences since 2015 and identifies aspects of Crosslinking MS for which guidelines should be developed as part of a Crosslinking MS standards initiative.
Figure S3 from Quantitative Whole Genome Sequencing of Circulating Tumor Cells Enables Personalized Combination Therapy of Metastatic Cancer (2023)

&lt;p&gt;Mutational spectrum of CTCs. The percent of particular base changes (labeled on the right of the figure) for different sets of mutations from CTCs, NA12877, and breast cancer from TCGA (BRCA) data are shown. Founder mutations and mutations found in 5 cells have a pattern very similar to that seen in breast cancer.&lt;/p&gt;
A convenient method for upgrading the enantiomeric purities of (+)-longifolene and (+)-3-carene to materials approaching 100% ee (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA convenient method for upgrading the enantiomeric purities of (+)-longifolene and (+)-3-carene to materials approaching 100% eePrabhakar K. Jadhav, J. V. N. Vara Prasad, and Herbert C. BrownCite this: J. Org. Chem. 1985, 50, 17, 3203–3206Publication Date (Print):August 1, 1985Publication History Published online1 May 2002Published inissue 1 August 1985https://pubs.acs.org/doi/10.1021/jo00217a036https://doi.org/10.1021/jo00217a036research-articleACS PublicationsRequest reuse permissionsArticle Views323Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Integrated CMOS photo-transistor array for visual light identification (ID) (2007)

The integrated CMOS photo-transistor array has been developed for visible light 1D system. And the photo-transistor is selected by CCD image and C software in order to separate the signals from multiple light sources.
Online Material Characterization Using Full-Field Strain Measurement (2011)

This paper presents and reviews an online methodology which characterizes materials using full-field strain measurement. The proposed methodology utilizes the principle of conservation of energy and formulates both the deterministic technique based on the pseudoinverse analysis and the stochastic technique based on the Kalman filter in terms of recursive linear equations. The methodology further describes the derivation the average Frobenius norm and the differential entropy as recursively computable measures enabling the evaluation of the well-posedness of the material characterization problem as well as the uncertainty of the identified constants. Comparative studies have identified that the deterministic identification is a particular case of the stochastic identification, whilst the adequacy and significance of both the average Frobenius norm and the differential entropy was reconfirmed.
Genomic structure of the transforming growth factor beta type II receptor gene and its mutations in hereditary nonpolyposis colorectal cancers. (1996)

To characterize the tumorigenetic role of the transforming growth factor beta type II receptor (RII) gene, we defined its genomic structure, which consists of seven exons. The sequences of exon-intron junctions were determined to facilitate mutation analysis of each exon. Twenty-five carcinomas and five adenomas from hereditary nonpolyposis colorectal cancer patients were analyzed for mutations in the entire coding region. Four missense mutations (two in adenomas and two in carcinomas) were found in the 10 cases carrying the polyadenine deletions in one allele. These results indicate that RII shares the two-hit inactivation mechanism with tumor suppressor genes and that mutations of it may occur in the early stage of tumorigenesis.
Liver X receptors and cholesterol homoeostasis: spotlight on the adrenal gland (2006)

The LXRs (liver X receptors) (LXRalpha and LXRbeta) are nuclear hormone receptors that are activated by oxysterols, endogenous oxidative metabolites of cholesterol. These receptors regulate an integrated network of genes that control whole body cholesterol and lipid homoeostasis. A brief overview of the mechanism of this regulation by LXRs in the liver, macrophage and intestine will be outlined, followed by data from our recent work demonstrating that LXRalpha is crucial in maintaining adrenal cholesterol homoeostasis. In the adrenal gland, oxysterols are formed as intermediates in the conversion of cholesterol into steroid hormones and can act as endogenous activators of LXR. We have found using both gain- and loss-of-function models that LXR acts to maintain free cholesterol below toxic levels in the adrenal gland, through the co-ordinated regulation of genes involved in cholesterol efflux [ABCA1 (ATP-binding-cassette transporter A1)], storage (sterol-regulatory-element-binding protein-1c and apolipoprotein E) and metabolism to steroid hormones (steroidogenic acute regulatory protein). Furthermore, we show that under chronic dietary stress, the adrenal glands of LXR-null mice (and not wild-type mice) accumulate free cholesterol. These results support the role of LXR as a global regulator of cholesterol homoeostasis, where LXR provides a safety valve to limit free cholesterol in tissues experiencing high cholesterol flux.
The transformations of toluene on alumina and bifunctional catalysts (2006)

The activity of Pt, Rh, and Ni catalysts deposited on Al2O3 and tungsten-containing catalysts 20% H4SiW12O40/ZrO2 and 15% WOx/ZrO2 in the hydrogenation of toluene and toluene ring opening and isomerization in the presence of hydrogen was studied. Under experimental conditions (160–360°C, 2.2 MPa), the main reactions on Rh/Al2O3 were the hydrogenation of toluene into methylcyclohexane, hydrogenolysis into isoheptanes, and hydrocracking into alkanes C1–C6. On Pt, Rh, and Ni catalysts on carriers with strong acid properties, the isomerization of the six-membered into five-membered ring followed by hydrogenolysis (hydrocracking) of alkylcyclopentanes occurred. The yield of heptane isomers, however, did not exceed 13%. The activity of Pt and Rh catalysts on a high-acidity carrier (WOx/ZrO2) in hydrocracking was much higher than that of catalysts based on deposited heteropoly acid. The yields of hydrogenolysis (hydrocracking) products on Ni/WOx/ZrO2 were much lower than on Pt(Rh)/WOx/ZrO2. The highest yield of ring opening products (isoheptanes and n-heptane) was obtained with layered loading of two catalysts; it reached 58 wt % at 300°C and a 2.2 MPa pressure, which was 4.5 and 2 times higher than the yield obtained on Ni-Pt/WOx/ZrO2 and 2% Rh/Al2O3 catalysts. Hydrodemethylation was not the main direction of toluene transformations on any of the catalysts studied.
Retracted: Synthesis and Cytotoxic Activity of 2‐Anilinopyridine‐3‐Acrylamides as Tubulin Polymerization Inhibitors (2014)

In an attempt to develop potent anticancer agents, a series of 2-anilinonicotinyl-linked acrylamide conjugates were designed, synthesized, and evaluated for cytotoxic activity against various human cancer cell lines, anti-tubulin activity and cell-cycle effects. Among the series, compounds 6 d [(E)-N-(6-fluorobenzo[d]thiazol-2-yl)-3-(2-((3,4,5-trimethoxyphenyl)amino)pyridin-3-yl)acrylamide] and 6 p [(E)-3-(2-((4-methoxyphenyl)amino)pyridin-3-yl)-N-(6-nitrobenzo[d]thiazol-2-yl)acrylamide] showed promising cytotoxicity, specifically against the A549 human lung adenocarcinoma epithelial cell line, with GI50 values of 0.6±0.23 and 1.8±0.22 μM, respectively. Furthermore, cell-cycle perturbation studies by flow cytometry analysis indicated drastic cell-cycle effects in the G2 /M phase in this cell line followed by caspase-3 activation and apoptotic cell death. Molecular docking studies of the most potent compound, 6 d, revealed that this compound interacts with and binds efficiently in the active site of tubulin.