gebhart/patrepeval huggingface dataset:
A touch of money [biometric authentication systems] (2006)

This paper suggests the use of a new authentication system for credit cards based on biometric sensors that could dramatically curtail identity theft. The proposed system uses fingerprint sensors, though other biometric technologies, either alone or in combination, could be incorporated. It could be economical, protect privacy, and guarantee the validity of all kinds of credit card transactions, including ones that take place at a store, over the telephone, or with an Internet-based retailer. By preventing identity thieves from entering the transaction loop, credit card companies could quickly recoup their infrastructure investments and save businesses, consumers, and themselves billions of dollars every year.
Evaluation of photoanode materials used in biophotovoltaic systems for renewable energy generation (2021)

An illustrative diagram of a biophotovoltaic system highlights its main components and several steps of electron transport.
Identifying Modulators of Protein−Protein Interactions Using Photonic Crystal Biosensors (2009)

Inhibitors and activators of protein-protein interactions are valuable as biological probes and medicinal agents but are often difficult to identify. Herein we describe a high-throughput assay, based upon photonic crystal (PC) biosensors, for the identification of modulators of protein-protein interactions. Through the use of a d-biotin-tris-NTA (BTN) hybrid compound, any His6-tagged protein can be immobilized on the surface of a PC biosensor. Binding of the bound protein to its cognate partner is detected via a shift in the peak wavelength value. We demonstrate this assay with three protein-protein pairs (caspase-9-XIAP, caspase-7-XIAP, FKBP12-FRB) and their small molecule modulators.
Personalized Stress Monitoring AI System For Healthcare Workers (2021)

In the current COVID-19 pandemic scenario, healthcare workers, in particular nurses, face prolonged exposure to stress. This intense duress takes a toll on their health overtime, affects their quality of life, and in turn impacts the quality of care provided to the patients. Hence, real-time detection and monitoring of stress is extremely important for early detection of stress patterns, prevention of burnouts and chronic conditions in healthcare workers as well as facilitate improved patient-care outcomes. In this paper, we present a proof-of-concept case study using machine learning (ML) and artificial intelligence (AI)-based stress detection model that determines a personalized assessment of stress level using heart rate, heart rate variability, and physical activity of the users. We used wearable electrocardiogram and inertial sensor to record heart activity and physical activity of nurses during their shifts. Our preliminary results indicate that the proposed stress tracking model can effectively predict any stress occurrences. This study is a pivotal attempt to emphasize the significance of stress-detection and relief for healthcare workers and provide them a tool for an effective assessment of personalized stress levels.
Extracellular Vesicles from Hyperammonemic Rats Induce Neuroinflammation and Motor Incoordination in Control Rats (2020)

Minimal hepatic encephalopathy is associated with changes in the peripheral immune system which are transferred to the brain, leading to neuroinflammation and thus to cognitive and motor impairment. Mechanisms by which changes in the immune system induce cerebral alterations remain unclear. Extracellular vesicles (EVs) seem to play a role in this process in certain pathologies. The aim of this work was to assess whether EVs play a role in the induction of neuroinflammation in cerebellum and motor incoordination by chronic hyperammonemia. We characterized the differences in protein cargo of EVs from plasma of hyperammonemic and control rats by proteomics and Western blot. We assessed whether injection of EVs from hyperammonemic to normal rats induces changes in neuroinflammation in cerebellum and motor incoordination similar to those exhibited by hyperammonemic rats. We found that hyperammonemia increases EVs amount and alters their protein cargo. Differentially expressed proteins are mainly associated with immune system processes. Injected EVs enter Purkinje neurons and microglia. Injection of EVs from hyperammonemic, but not from control rats, induces motor incoordination, which is mediated by neuroinflammation, microglia and astrocytes activation and increased IL-1β, TNFα, its receptor TNFR1, NF-κB in microglia, glutaminase I, and GAT3 in cerebellum. Plasma EVs from hyperammonemic rats carry molecules necessary and sufficient to trigger neuroinflammation in cerebellum and the mechanisms leading to motor incoordination.
Microscopic cooperative traffic flow: calibration and simulation based on a next generation simulation dataset (2014)

The deployment of new emerging technologies, such as cooperative systems, allows the traffic community to foresee relevant improvements in terms of traffic safety and efficiency. Autonomous vehicles are able to share information about the local traffic state in real time, which could result in a better reaction to the mechanism of traffic jam formation. An upstream single‐hop radio broadcast network can improve the perception of each cooperative driver within a specific radio range and hence the traffic stability. The impact of vehicle to vehicle cooperation on the onset of traffic congestion is investigated analytically and through simulation. A next generation simulation field dataset is used to calibrate the full velocity difference car‐following model, and the MOBIL lane‐changing model is implemented. The robustness of the calibration as well as the heterogeneity of the drivers is discussed. Assuming that congestion can be triggered either by the heterogeneity of drivers’ behaviours or abnormal lane‐changing behaviours, the calibrated car‐following model is used to assess the impact of a microscopic cooperative law on egoistic lane‐changing behaviours. The cooperative law can help reduce and delay traffic congestion and can have a positive effect on safety indicators.
Sonochemical Synthesis of Air-Insensitive Carbide-Stabilized Hafnium Subhydride Nanopowder (2009)

An air-passivated hafnium subhydride subcarbide nanopowder of the formula Hf3.47C1.00H2.40Li0.10O0.12 was prepared via a slurry sonochemical reaction of HfCl4 and LiH, followed by a 900 °C vacuum anneal. HRTEM of the nanopowder revealed crystallites of 10 nm average diameter that are agglomerated into larger porous structures.
TRANSCRIPTION AND REVERSE TRANSCRIPTION OF RETROTRANSPOSONS (1989)

Replication des retrotransposons: article de synthese. Presentation des classes principales de retrotransposons. Transcription. Reverse transcription
FlexCase (2016)

FlexCase is a novel flip cover for smartphones, which brings flexible input and output capabilities to existing mobile phones. It combines an e-paper display with a pressure- and bend-sensitive input sensor to augment the capabilities of a phone. Due to the form factor, FlexCase can be easily transformed into several different configurations, each with different interaction possibilities. Users can use FlexCase to perform a variety of touch, pressure, grip and bend gestures in a natural manner, much like interacting with a sheet of paper. The secondary e-paper display can act as a mechanism for providing user feedback and persisting content from the main display. In this paper, we explore the rich design space of FlexCase and present a number of different interaction techniques. Beyond, we highlight how touch and flex sensing can be combined to support a novel type of gestures, which we call Grip & Bend gestures. We also describe the underlying technology and gesture sensing algorithms. Numerous applications apply the interaction techniques in convincing real-world examples, including enhanced e-paper reading and interaction, a new copy and paste metaphor, high degree of freedom 3D and 2D manipulation, and the ability to transfer content and support input between displays in a natural and flexible manner.
ChemInform Abstract: Photochemical Synthesis of Magnesium Dihydride and Methyl Magnesium Hydride in Cryogenic Matrices. (1986)

Abstract Photoexcitation of matrix‐isolated Mg atoms at the 3plP ‐3s′Sresonance transition in 10% H 2 containing rare gas öir heatprhethane matrices at 12 Kresults in the formation of MgH 2 and CH 3 MgH, respectively.
Probe-level linear model fitting and mixture modeling results in high accuracy detection of differential gene expression (2006)

The method achieves, on this dataset, a higher accuracy than the best set of tools identified by the authors of the dataset, and does so using only one replicate per condition.
Observation of Anharmonic Coupling in the Time Domain with Femtosecond Stimulated Raman (2006)

Coherent motion of low frequency bending vibrations is impulsively excited in CDCl3 and subsequent couplings between the C-D stretch and the low frequency coherences are detected in real time by femtosecond stimulated Raman spectroscopy (FSRS).
713. Gene Correction Therapy Using Designed Zinc Finger-Based Endonucleases (2004)

Human monogenic disorders, such as X-linked SCID, cystic fibrosis, sickle cell anemia, and hemophilia, are caused by hypomorphic or null mutations in a single gene, and restoration of even a single wild-type allele in a sub-population of cells can be curative. In practice, however, resistance to homologous recombination (HR) is a universal feature of mammalian genomes. An important exception to this rule occurs during repair of double-strand breaks (DSBs), which are healed by conversion – a unidirectional transfer of genetic information missing at the break from a homologous sequence such as a sister chromatid. Extensive analysis with reporter genes engineered to contain recognition sites for rare endonucleases validated the notion that a DSB potentiates homologous recombination by several orders of magnitude. The concept of targeted DSB-driven genome editing can be expanded from reporter genes to any endogenous locus via the use of zinc finger protein-based chimeric endonucleases (ZFNs): enzymes whose DNA cleavage specificity is determined by a designed zinc finger protein, engineered to bind specifically to a sequence at the mutated locus. We present data on the use of such ZFNs to introduce defined nucleotide changes at several endogenous loci in the human genome, including the IL2Rg and b-globin loci. Use of such in the context of the clinic will require high-frequency targeting. We present data on optimization of the targeting protocol that reproducibly yields > 10' gene-targeted cells in a given population in the absence of any selective pressure. This approach to gene correction could be used to treat monogenic disorders such as X-linked SCID and Sickle Cell Anemia.
CYCLOSPORIN A (CSA) AND COMPLEMENT MEDIATE VASCULAR AND PLATELET ACTIVATION IN ALLOGRAFTS. (2000)

Ota, Hirofumi1; Hu, Weimin1; Qian, Zhiping1; Sanfilippo, Fred1; Hruban, Ralph H.1; III, William M. Baldwin1 Author Information
Combining tire-wear and braking control for aeronautical applications (2019)

In ground vehicles, tire consumption is in general mainly due to the mileage covered, and in fact the life span of tires, at least in common situations, is rather long. In the aeronautical context, and for aircraft in particular, instead, tire consumption plays a crucial role in determining the maintenance costs. This is due to the fact that, in aircraft braking, nearly all maneuvers activate the anti-skid controller, which remains in use for long time intervals. In ground vehicles, instead ABS systems are usually active for short time intervals which cover a part of the braking maneuvers only. Thus, tire consumption in the automotive context is usually studied under constant speed assumptions. In this work, we formulate a tire consumption models that encompasses explicitly the wheel acceleration/deceleration dynamics, and we show that tire wear can be directly related to the anti-skid controller parameters. Based on this, a sensitivity analysis of tire-consumption versus braking performance is carried out, showing that the braking control problem can be reformulated as a tire consumption regulation one.
Catalytic Combustion of Effluents from Methane-Based MCFC Device over Cordierite Supported Pd/La-Al<sub>2</sub>O<sub>3</sub> Catalyst (2008)

Influence of steam, loading amounts of Pd (viz., 0.7, 2.1, 5.4 wt %) and other process parameters (viz. GHSV and temperature) on methane-based MCFC anodeeffluents over Pd-based La2O3-Al2O3 supported on honeycomb substrate have been investigated. TGA study reveals precise temperature of decomposition of Pd-O in catalytic combustion at high temperature. An increase in methane conversion at elevated temperature is attributable to decomposition of PdO to Pd active phase. The XRD analysis of spent catalysts suggests that the reflections corresponding to PdO gradually become weaker with increase in the Pd loading. The addition of 4% water in the feed decreases the methane conversion due to the reversible reaction of PdO with water adduct resulting in the formation of inactive Pd(OH)2 phase. However, the methane conversion remains unaffected and increases monotonously with 100% water concentration in the feed.
Innovative therapeutic strategy for B-cell malignancies that combines obinutuzumab and cytokine-induced killer cells (2021)

The combination of an easily expandable CIK cell effector population with a mAb already in clinical use establishes a tumor antigen-specific redirection strategy that can be rapidly translated into clinical practice, providing an effective therapeutic alternative for B-cell malignancies without any need for genetic modifications. Additionally, the approach can be potentially applied to an extremely vast array of different tumors by simply substituting the targeting mAb.
Evidence of human infection by a new mammarenavirus endemic to Southeastern Asia (2016)

Southeastern Asia is a recognised hotspot for emerging infectious diseases, many of which have an animal origin. Mammarenavirus infections contribute significantly to the human disease burden in both Africa and the Americas, but little data exists for Asia. To date only two mammarenaviruses, the widely spread lymphocytic choriomeningitis virus and the recently described Wēnzhōu virus have been identified in this region, but the zoonotic impact in Asia remains unknown. Here we report the presence of a novel mammarenavirus and of a genetic variant of the Wēnzhōu virus and provide evidence of mammarenavirus-associated human infection in Asia. The association of these viruses with widely distributed mammals of diverse species, commonly found in human dwellings and in peridomestic habitats, illustrates the potential for widespread zoonotic transmission and adds to the known aetiologies of infectious diseases for this region.
Spin Accumulation in Metallic Nanoparticles (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Carotid Artery Disease: What You Should Know When Experiencing Your First TIA (2001)

Washington University, School of Medicine, St. Louis, Missouri University of Cambridge, Addenbrooke's Hospital, Cambridge, England
DOJO: The Microarchitecture of Tesla’s Exa-Scale Computer (2022)

Tesla’s in-house supercomputer for Machine Learning
A Genetic Variation of SOD2 Does Not Determine Duration of Response to Androgen Deprivation Therapy for Prostate Cancer (2016)

Our result suggests that a functional genetic variant in SOD2 does not determine the efficacy of ADT for prostate cancer. It is possible that the drastic downregulation of SOD2 in advanced prostate cancer cells may have overridden any influence of the genetic variation of SOD2. This study suggests the need for careful consideration about timing if the application of SOD2 mimetics for prostate cancer therapy is considered. Prostate 76:1338-1341, 2016. © 2016 Wiley Periodicals, Inc.
Data from Rapid Serial Immunoprofiling of the Tumor Immune Microenvironment by Fine Needle Sampling (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;There is increasing effort to discover and integrate predictive and/or prognostic biomarkers into treatment algorithms. While tissue-based methods can reveal tumor–immune cell compositions at a single time point, we propose that single-cell sampling via fine needle aspiration (FNA) can facilitate serial assessment of the tumor immune microenvironment (TME) with a favorable risk–benefit profile.&lt;/p&gt;Experimental Design:&lt;p&gt;Primary antibodies directed against 20 murine and 25 human markers of interest were chemically modified via a custom linker–bio-orthogonal quencher (FAST) probe. A FAST-FNA cyclic imaging and analysis pipeline were developed to derive quantitative response scores. Single cells were harvested via FNA and characterized phenotypically and functionally both in preclinical and human samples using the newly developed FAST-FNA assay.&lt;/p&gt;Results:&lt;p&gt;FAST-FNA samples analyzed manually versus the newly developed deep learning–assisted pipeline gave highly concordant results. Subsequently, an agreement analysis showed that FAST and flow cytometry of surgically resected tumors were positively correlated with an R&lt;sup&gt;2&lt;/sup&gt; = 0.97 in preclinical samples and an R&lt;sup&gt;2&lt;/sup&gt; = 0.86 in human samples with the detection of the relevant tumor and immune biomarkers of interest. Finally, the feasibility of applying this minimally invasive approach to analyze the TME during immunotherapy was assessed in patients with cancer revealing local antitumor immune programs.&lt;/p&gt;Conclusions:&lt;p&gt;The FAST-FNA is an innovative technology that combines bio-orthogonal chemistry coupled with a computational analysis pipeline for the comprehensive profiling of single cells obtained through FNA. This is the first demonstration that the complex and rapidly evolving TME during treatment can be accurately and serially measured by simple FNA.&lt;/p&gt;&lt;/div&gt;
Not nanocarbon but dispersant induced abnormality in lysosome in macrophages in vivo (2015)

The properties of nanocarbons change from hydrophobic to hydrophilic as a result of coating them with dispersants, typically phospholipid polyethylene glycols, for biological studies. It has been shown that the dispersants remain attached to the nanocarbons when they are injected in mice and influence the nanocarbons' biodistribution in vivo. We show in this report that the effects of dispersants also appear at the subcellular level in vivo. Carbon nanohorns (CNHs), a type of nanocarbon, were dispersed with ceramide polyethylene glycol (CPEG) and intravenously injected in mice. Histological observations and electron microscopy with energy dispersive x-ray analysis revealed that, in liver and spleen, the lysosome membranes were damaged, and the nanohorns formed a complex with hemosiderin in the lysosomes of the macrophages. It is inferred that the lysosomal membrane was damaged by sphigosine generated as a result of CPEG decomposition, which changed the intra lysosomal conditions, inducing the formation of the CPEG-CNH and hemosiderin complex. For comparison, when glucose was used instead of CPEG, neither the nanohorn–hemosiderin complex nor lysosomal membrane damage was found. Our results suggest that surface functionalization can control the behavior of nancarbons in cells in vivo and thereby improve their suitability for medical applications.
Efficient induction of protective anti-malaria immunity by recombinant adenovirus (1998)

The immunogenicity of a previously constructed replication-defective recombinant adenovirus expressing the CS protein of Plasmodium yoelii was compared with that of irradiated sporozoites. We found that immunization of BALB/c mice with a single dose of this recombinant adenovirus induced a much greater CS-specific T-cell response compared with immunization with irradiated sporozoites. More importantly, we found that this recombinant adenovirus induces similar or higher levels of protective immunity than those induced by irradiated sporozoites, eliciting an appreciable resistance to malaria infection.
Propionyl- l -Carnitine Improves Postischemic Blood Flow Recovery and Arteriogenetic Revascularization and Reduces Endothelial NADPH-Oxidase 4–Mediated Superoxide Production (2010)

Our results provided strong evidence that PLC improves postischemic flow recovery and revascularization and reduces endothelial NADPH-oxidase-related superoxide production. We recommend that PLC should be included among therapeutic interventions that target endothelial function.
Intracellular Metabolism of β- l -2′,3′-Dideoxyadenosine: Relevance to Its Limited Antiviral Activity (2000)

The intracellular metabolism of the beta-L- enantiomer of 2', 3'-dideoxyadenosine (beta-L-ddA) was investigated in HepG2 cells, human peripheral blood mononuclear cells (PBMC), and primary cultured human hepatocytes in an effort to understand the metabolic basis of its limited activity on the replication of human immunodeficiency virus and hepatitis B virus. Incubation of cells with 10 microM [2',3',8-(3)H]-beta-L-ddA resulted in an increased intracellular concentration of beta-L-ddA with time, demonstrating that these cells were able to transport beta-L-ddA. However, it did not result in the phosphorylation of beta-L-ddA to its pharmacologically active 5'-triphosphate (beta-L-ddATP). Five other intracellular metabolites were detected and identified as beta-L-2', 3'-dideoxyribonolactone, hypoxanthine, inosine, ADP, and ATP, with the last being the predominant metabolite, reaching levels as high as 5.14 +/- 0.95, 8.15 +/- 2.64, and 15.60 +/- 1.74 pmol/10(6) cells at 8, 4, and 2 h in HepG2 cells, PBMC, and hepatocytes, respectively. In addition, a beta-glucuronic derivative of beta-L-ddA was detected in cultured hepatocytes, accounting for 12.5% of the total metabolite pool. Coincubation of hepatocytes in primary culture with beta-L-ddA in the presence of increasing concentrations of 5'-methylthioadenosine resulted in decreased phosphorolysis of beta-L-ddA and formation of associated metabolites. These results indicate that the limited antiviral activity of beta-L-ddA is the result of its inadequate phosphorylation to the nucleotide level due to phosphorolysis and catabolism of beta-L-ddA by methylthioadenosine phosphorylase (EC 2.4.2.28).
Fusogenic porous silicon nanoparticles as a broad-spectrum immunotherapy against bacterial infections (2021)

Bacterial infections are re-emerging as substantial threats to global health due to the limited selection of antibiotics that are capable of overcoming antibiotic-resistant strains. By deterring such mutations whilst minimizing the need to develop new pathogen-specific antibiotics, immunotherapy offers a broad-spectrum therapeutic solution against bacterial infections. In particular, pathology resulting from excessive immune response (i.e. fibrosis, necrosis, exudation, breath impediment) contributes significantly to negative disease outcome. Herein, we present a nanoparticle that is targeted to activated macrophages and loaded with siRNA against the Irf5 gene. This formulation is able to induce >80% gene silencing in activated macrophages in vivo, and it inhibits the excessive inflammatory response, generating a significantly improved therapeutic outcome in mouse models of bacterial infection. The versatility of the approach is demonstrated using mice with antibiotic-resistant Gram-positive (methicillin-resistant Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa) muscle and lung infections, respectively. Effective depletion of the Irf5 gene in macrophages is found to significantly improve the therapeutic outcome of infected mice, regardless of the bacteria strain and type.