gebhart/patrepeval huggingface dataset:
BreakSense (2017)

Work breaks can play an important role in the mental and physical well-being of workers and contribute positively to productivity. In this paper we explore the use of activity-, physiological-, and indoor-location sensing to promote mobility during work-breaks. While the popularity of devices and applications to promote physical activity is growing, prior research highlights important constraints when designing for the workplace. With these constraints in mind, we developed BreakSense, a mobile application that uses a Bluetooth beacon infrastructure, a smartphone and a smartwatch to encourage mobility during breaks with a game-like design. We discuss constraints imposed by design for work and the workplace, and highlight challenges associated with the use of noisy sensors and methods to overcome them. We then describe a short deployment of BreakSense within our lab that examined bound vs. unbound augmented breaks and how they affect users' sense of completion and readiness to work.
Cascade 4+1 RadicalAnnulations of 2,6-Disubstituted Phenyl Isonitriles with N-Propargyl-6-Iodopyridones: Scope, Mechanismand Regioselective Synthesis of 7,9-Disubstituted Camptothecin Analogs (2003)

The reaction of o,o′-dialkyl-substituted aryl isonitriles with N-propargyl-6-iodopyridones provides 11H-indolizino[1,2-b]quinolin-9-ones with significant regioselectivity in favor of the more crowded product. The usefulness of the method is illustrated with a regioselective synthesis of (20S)-7-trimethylsilyl-9-isopropyl camptothecin.
Multiplexed host immune response biosensor for rapid sepsis stratification and endotyping at point-of-care (2022)

Disease progression of sepsis has been perceived as a multifaceted phenomenon, considering the temporal host inflammatory response within individuals which requires early diagnosis. Herein, we present a multicohort analysis through temporal inflammatory biomarker profiling using Direct Electrochemical Technique Targeting (DETecT) sepsis device that measures and quantify cytokines (IL-6, IL-8, IL-10), chemokines (TRAIL, IP-10), and well-established inflammatory biomarkers (PCT, CRP) with a sample turnaround time of <5 min in small volume (<40 μL) patient plasma samples. The DETecT device positively correlated (r > 0.97) with the Luminex reference standard during clinical evaluation for a total of 124 sepsis patient samples. Low mean bias for all the biomarkers in Bland- Altman analysis indicated good agreement between the standard LUMINEX method and the developed DETecT sepsis device. We used the combinatorial power of rapidly measuring a panel of seven biomarkers, paired with a machine learning model, to effectively predict the patient outcomes when given two-time points in the early stages of sepsis. The device could predict patient mortality and recovery with over 92% accuracy by applying decision tree analysis. We envision this work would facilitate personalized treatment based on biomarker stratification to represent exactly where the patient belongs within the sepsis continuum. Measurable empirical data with a fast turnaround time would facilitate the DETecT sepsis device as a potential enabling technology that can play a crucial role in understanding sepsis prognosis and be leveraged for personalized therapeutics anywhere.
A mobile system for assessment of physiological response to posture transitions (2013)

Posture changes initiate a dynamic physiological response that can be used as an indicator of the overall health status. We introduce an inconspicuous mobile wellness monitoring system (imWell) that continuously assesses the dynamic physiological response to posture transitions during activities of daily living. imWell utilizes a Zephyr BioHarness 3 physiological monitor that continually reports heart activity and physical activity via Bluetooth to a personal device (e.g. smartphone). The personal device processes the reported activity data in real-time to recognize posture transitions from the accelerometer data and to characterize dynamic heart response to posture changes. It annotates, logs, and uploads the heart activity data to our mHealth server. In this paper we present algorithms for detection of posture transitions and heart activity characterization during a sit-to-stand transition. The proposed system was tested on seven healthy subjects performing a predefined protocol. The total average and standard deviation for sit-to-stand transition time is 2.7 ± 0.69 s, resulting in the change of heart rate of 27.36 ± 9.30 bpm (from 63.3 ± 9.02 bpm to 90.66 ± 10.09 bpm).
First Field Trial of Sensing Vehicle Speed, Density, and Road Conditions by Using Fiber Carrying High Speed Data (2019)

For the first time, we demonstrate detection of vehicle speed, density, and road conditions using deployed fiber carrying high-speed data transmission, and prove carriers' large-scale fiber infrastructures can also be used as ubiquitous sensing networks.
Performance of chip-level differential detection with phase noise (2004)

Chip-level differential encoding/detection of direct-sequence spread-spectrum signals has been shown to improve receiver robustness in the presence of oscillator frequency offsets and fast fading channels. These gains are achieved at the expense of SNR performance in an AWGN channel, with spreading factor governing the tradeoff. This paper explores the performance of chip-level differential detection in the presence of oscillator phase noise. It is shown that phase noise mitigation is an additional benefit of chip-level differential detection, with higher spreading factors permitting the use of lower-cost, noisier oscillators. Simulations of a DS/SS BPSK system illustrate the relationship between phase noise tolerance and spreading factor, and a simple analytical model is derived for efficient evaluation of systems with high spreading factor.
Effects of Reducing Norepinephrine Levels via DSP4 Treatment on Amyloid-β Pathology in Female Rhesus Macaques (Macaca Mulatta) (2019)

The degeneration in the locus coeruleus associated with Alzheimer's disease suggests an involvement of the noradrenergic system in the disease pathogenesis. The role of depleted norepinephrine was tested in adult and aged rhesus macaques to develop a potential model for testing Alzheimer's disease interventions. Monkeys were injected with the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) or vehicle at 0, 3, and 6 months; brains were harvested at 9 months. Reduced norepinephrine in the locus coeruleus was accompanied by decreased dopamine β-hydroxylase staining and increased amyloid-β load in the aged group, and the proportion of potentially toxic amyloid-β42 peptide was increased. Immunohistochemistry revealed no effects on microglia or astrocytes. DSP4 treatment altered amyloid processing, but these changes were not associated with the induction of chronic neuroinflammation. These findings suggest norepinephrine deregulation is an essential component of a nonhuman primate model of Alzheimer's disease, but further refinement is necessary.
Precisely printable and biocompatible silk fibroin bioink for digital light processing 3D printing (2018)

Although three-dimensional (3D) bioprinting technology has gained much attention in the field of tissue engineering, there are still several significant engineering challenges to overcome, including lack of bioink with biocompatibility and printability. Here, we show a bioink created from silk fibroin (SF) for digital light processing (DLP) 3D bioprinting in tissue engineering applications. The SF-based bioink (Sil-MA) was produced by a methacrylation process using glycidyl methacrylate (GMA) during the fabrication of SF solution. The mechanical and rheological properties of Sil-MA hydrogel proved to be outstanding in experimental testing and can be modulated by varying the Sil-MA contents. This Sil-MA bioink allowed us to build highly complex organ structures, including the heart, vessel, brain, trachea and ear with excellent structural stability and reliable biocompatibility. Sil-MA bioink is well-suited for use in DLP printing process and could be applied to tissue and organ engineering depending on the specific biological requirements.
Carbon Nanotube/Nanofibers and Graphite Hybrids for Li‐Ion Battery Application (2014)

To improve the electrical conductivity of negative electrodes of lithium ion batteries, we applied a direct CVD synthesis of carbon nanomaterials on the surface of graphite particles. To prepare a catalyst, two alternative approaches were utilized: colloidal nanoparticles (NPs) and metal (Ni and Co) nitrate salt precursors deposited on the graphite surface. Both colloidal and precursor systems allowed us to produce carbon nanofibers (CNFs) on the graphite surface with high coverage under the optimum CVD conditions. Electrical measurements revealed that the resistivity of the actual electrodes fabricated from CNFs coated graphite particles was about 40% lower compared to the original pristine graphite electrodes.
Self-powered resonant frequency tuning for Piezoelectric Vibration Energy Harvesters (2013)

This paper reports on the design, fabrication and testing of an innovative 33-mode piezoelectric vibration energy harvester (VEH). This system is able to change its resonant frequency in real time to follow the main frequency of a vibration source. The system proposed in this paper enables to adapt VEH characteristics (resonant frequency, electrical damping) to vibration parameters variations (frequency and amplitude) in order to optimize the extraction of energy and then the output power at any time. This solution allows up to 40% of resonant frequency tuning ratio; moreover, the adaptation is made in real time and the consumption of the regulation electronic is less than 10% of the VEH output power (480μW@0.1g-276Hz).
Fast Ion Bombardment (FIB) (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Development and extraction of high-frequency SPICE models for metal-insulator-metal capacitors (2004)

In the framework of a lumped-element SPICE model, we extract RF parameters for a MIM capacitor, such as series resistance and inductance. The extraction method is validated through a "dummy" MIM capacitor where the dielectric layer is omitted during the fabrication process. A distributed model provides a good fit to measured data; fits to Q(f) and C(f) are replicated using a lumped model as well.
TPTR - Ein Transportprotokoll mit einstellbarer Zuverlässigkeit für drahtlose Streaming-Anwendungen (2004)

Dieser Beitrag stellt Elemente des neuen TPTR-Protokolls fur drahtlose Streaming-Anwendungen vor, welches mit Prioritaten arbeitet und fur die einzelnen Prioritatsklassen eine einstellbare Zuverlassigkeit ermoglicht. Die vorgestellten Konzepte verbessern die Wiedergabe beim Streaming im Vergleich zu vorhandenen Algorithmen und ermoglichen eine kontrollierte Anpassung der Wiedergabequalitat bei temporaren Linkverlusten.
ChemInform Abstract: SIMPLE AND DIRECT SYNTHESIS OF TRANS‐1,2‐BIS(TRIBUTYLSTANNYL)ETHYLENE (1982)

Abstract Tributylzinnchlorid (I) und Li‐acetylid (II) ergeben zunächst ein Gemisch aus Mono‐ (III) und Bis‐Kondensationsprodukt (IV).
A33-1 Preliminary results of a novel design of a far field signal reduction (FFSR) bipolar lead (2003)

EUROPACEhigher incidence of AF was associated with the presence of preprocedural AF, a history of cardioversion, and the number of anti-arhythmic drugs (AAD) used before.ACE-I and diuretics were associated with less frequent development of AF despite the fact that more patients taking these drugs had stmchml heart disease (82% versus 33%) (ACE-I: RR:0.57, p=O.O3; diuretics: RR:0.30, p<O.Ol).This association remained significant in a multivariate analysis with correction for the aforementioned risk factors, stmchml heart disease and age (ACE-I: RR: 0.55, p=O.O4; diuretics: RR: 0.
Supplementary Table 4 from Tumor Suppressor Functions of miR-133a in Colorectal Cancer (2023)

&lt;p&gt;PDF file - 81K, Clinicopathological correlation of miR-133a expression in CRC.&lt;/p&gt;
Impact of CodY protein on metabolism, sporulation and virulence in Clostridioides difficile ribotype 027 (2019)

Toxin synthesis and endospore formation are two of the most critical factors that determine the outcome of infection by Clostridioides difficile. The two major toxins, TcdA and TcdB, are the principal factors causing damage to the host. Spores are the infectious form of C. difficile, permit survival of the bacterium during antibiotic treatment and are the predominant cell form that leads to recurrent infection. Toxin production and sporulation have their own specific mechanisms of regulation, but they share negative regulation by the global regulatory protein CodY. Determining the extent of such regulation and its detailed mechanism is important for understanding the linkage between two apparently independent biological phenomena and raises the possibility of creating new ways of limiting infection. The work described here shows that a codY null mutant of a hypervirulent (ribotype 027) strain is even more virulent than its parent in a mouse model of infection and that the mutant expresses most sporulation genes prematurely during exponential growth phase. Moreover, examining the expression patterns of mutants producing CodY proteins with different levels of residual activity revealed that expression of the toxin genes is dependent on total CodY inactivation, whereas most sporulation genes are turned on when CodY activity is only partially diminished. These results suggest that, in wild-type cells undergoing nutrient limitation, sporulation genes can be turned on before the toxin genes.
Synthesis and compressibility of Ti3(Al,Sn0.2)C2 and Ti3Al(C0.5,N0.5)2 (2007)

In this paper we report on the synthesis of a composition, Ti3Al(C0.5,N0.5)2, belonging to the Mn+1AXn family of ternary layered carbides and nitrides. X-ray and selected area diffraction confirm that this compound is isostructural with Ti3SiC2; its a and c-lattice parameters are 3.0404(5) and 18.414(6) Å, respectively. Chemical analysis performed by electron dispersive and electron energy loss spectroscopy confirmed the Ti3AlCN chemistry. Using a synchrotron radiation source and a diamond anvil cell, we also measured the pressure dependencies of the lattice parameters. Up to a pressure of ≈50 GPa, no phase transformations were observed. The bulk modulus is 219±4 GPa, with a pressure derivative, Ko′, of 3.7±0.3. We also fabricated the ternary Ti3AlC2, with some Sn [nominal composition Ti3(AlSn0.2)C2]. Its a and c-lattice parameters are 3.0804(7) and 18.5426(7) Å, respectively. Its bulk modulus is 226±3 GPa, with a pressure derivative, Ko′, of ≈4. In both cases, the compressibility was greater along the c than along the a axes. We also show that in the case of Tin+1AlCn MAX-phases, replacing C by N results in a decrease in both lattice parameters and bulk moduli. The apparent contradiction inherent in this observation can be reconciled by assuming that the addition of N results in the formation of vacancies on the Al and/or X-sites.
Contributions to the Mechanism of Isobutene Polymerization. II. Effect ofn-Alkenes on Yields and Molecular Weights and Effect of Temperature on Poison Coefficients and Transfer Coefficients (1967)

Abstract The effect of n-alkenes, i.e., propylene, 1-butene, 1-pentene, 1-hexane, and 2-octene, on the yield and molecular weight of polyisobutene obtained with AlCl3 catalyst in n-pentane solvent at −78°C has been investigated. It has been found that the lower 1-alkenes are pure poisons; i.e., they decrease the yield (rate poisons) but do not affect product molecular weight. The rate-decreasing effect of n-alkenes has been treated quantitatively by poison coefficients and their numerical values correlated with relative carbonium ion stabilities using the allylic termination concept. The mild molecular weight decreasing effect of 2-octene has been attributed to moderate transfer activity. The effect of temperature on the poison coefficients of 2-octene has been investigated and some insight into the activation energies of various elementary steps has been gained.
Silver-Coated Biologically Active Protein Hybrids: Antimicrobial Applications (2015)

Novel hybrids, comprised of a biologically active protein molecule core, coated with a thin outer layer of porous metallic silver, were developed in our lab. By the conjugation of silver reducing polymer to the surface of soluble, molecular, biologically active protein molecules and subsequent addition of silver salt, electroless silver deposition, culminating in thin porous metallic coating, was directed to the surface of the protein molecules. The silver-protein hybrids thus obtained, presenting novel nanoparticles several nanometers in size, retained their solubility and biological activity.The silver coating combined with the retained biological activity of its protein core, paved the way to a series of biomedical applications of these hybrids including "wiring" of the active site of oxido-reductase enzyme to electrodes, imaging of the presence of targeted ligands displayed on cancer cell surface and antimicrobial enzymatically attenuated release of silver ions.In this presentation we shall overview the technology of protein-silver hybrid's fabrication and analytical applications of silver-glucose oxidase and silver-Avidin hybrids, followed by feasibility demonstration of using silver-glucose oxidase hybrid as novel antibacterial and antifungal agent.
POSTHARVEST CONTROL OF BOTRYTIS CINEREA INFECTIONS ON CUT ROSE FLOWERS WITH PYRROLNITRIN. (1990)

Pyrrolnitrin, an antibiotic isolated from Pseudomonas cepacia, was used for postharvest control of B. cinerea infections on cut `Sonia' and `Royalty' rose flowers. Pyrrolnitrin was applied as a bud dip and followed by inoculation with B. cinerea conidia. Dip treatments of 12 to 200 mg·liter -1 pyrrolnitrin significantly reduced disease severity during storage at 2C and promoted post-storage fresh weight gain (an index of cut flower quality). No phytoxicity was observed on leaves or petals at concentrations of up to 200 mg/liter. Dip treatment with 100 mg/liter pyrrolnitrin reduced disease severity to &lt;10% of that on control flowers and prevented post-storage flower rot. This level of disease control was comparable to that achieved with 1800 mg/liter vinclozolin.
Dusty Thermal Vacuum (DTVAC) Facility Payloads Operations under Simulated Lunar Environment (2021)

The dusty thermal vacuum (DTVAC) lunar and/or Mars environmental testing facility was designed and built to simulate the relatively extreme lunar near-surface conditions. DTVAC can accommodate test devices up to 1 × 1 × 0.9 m3 in volume, including smaller robotic assemblies, small drill assemblies, science payloads, and surface devices such as radiators and solar panels. Depending on the testing requirements, cooling can be provided either using a recirculating chiller to about 213 K or using LN2 down to about 90 K. In addition, cooling within the DTVAC facility to 41 K using liquid helium was successfully validated on a smaller, 0.25 m × 0.25 m, platen covered with lunar regolith simulant. For the LHe platen cooling, the shroud was cooled using LN2 to provide a thermal buffer. Recently, the DTVAC facility was equipped with an additional 25 Type-T thermocouples to improve its temperature monitoring capabilities, and a 1 to 200 amu residual gas analyzer (RGA) in order to identify the molecular composition of any outgassing from articles under test. A LN2-cooled cold finger was also installed to assist the system vacuum pump down and to facilitate the study of in-situ volatiles. This paper reviews the DTVAC upgrades, functionality calibrations, and summarizes its current capabilities.
Polygenic and clinical risk scores and their impact on age at onset of cardiometabolic diseases and common cancers (2019)

ABSTRACT Background Polygenic risk scores (PRS) have shown promise in predicting susceptibility to common diseases. However, the extent to which PRS and clinical risk factors act jointly and identify high-risk individuals for early onset of disease is unknown. Methods We used large-scale biobank data (the FinnGen study; n=135,300), with up to 46 years of prospective follow-up, and the FINRISK study with standardized clinical risk factor measurements to build genome-wide PRSs with &gt;6M variants for coronary heart disease (CHD), type 2 diabetes (T2D), atrial fibrillation (AF), and breast and prostate cancer. We evaluated their associations with first disease events, age at disease onset, and impact together with routinely used clinical risk scores for predicting future disease. Results Compared to the 20-80 th percentiles, a PRS in the top 2.5% translated into hazard ratios (HRs) for incident disease ranging from 2.03 to 4.28 (p-values 1.96×10 −59 to &lt;1.00×10 −100 ) and the bottom 2.5% into HRs ranging from 0.20 to 0.61. The estimated difference in age at disease onset between top and bottom 2.5% of PRSs was 6 to 13 years. Among early-onset cases, 21.3-32.9% had a PRS in the highest decile and in CHD and AF. Conclusions The properties of PRS were similar in all five diseases. PRS identified a considerable proportion early-onset cases, and for all ages the performance of PRS was comparable to established clinical risk scores. These findings warrant further clinical studies on application of polygenic risk information for stratified screening or for guiding lifestyle and preventive medical interventions.
Dual-wavelength DBR fiber laser (2006)

Stable continuous-wave lasing of two longitudinal modes of a distributed Bragg reflector fiber laser is reported. Intensity noise and coupling between the modes was characterized for both 0.8- and 0.2-nm mode separations
A model project for reproducible papers: critical temperature for the Ising model on a square lattice (2014)

In this paper we present a simple, yet typical simulation in statistical physics, consisting of large scale Monte Carlo simulations followed by an involved statistical analysis of the results. The purpose is to provide an example publication to explore tools for writing reproducible papers. The simulation estimates the critical temperature where the Ising model on the square lattice becomes magnetic to be Tc /J = 2.26934(6) using a finite size scaling analysis of the crossing points of Binder cumulants. We provide a virtual machine which can be used to reproduce all figures and results.