gebhart/patrepeval huggingface dataset:
Cerebrovascular Impedance as a Function of Cerebral Perfusion Pressure (2023)

<i>Goal:</i> Cerebrovascular impedance is modulated by a vasoactive autoregulative mechanism in response to changes in cerebral perfusion pressure. Characterization of impedance and the limits of autoregulation are important biomarkers of cerebral health. We developed a method to quantify impedance based on the spectral content of cerebral blood flow and volume at the cardiac frequency, measured with diffuse optical methods. <i>Methods:</i> In three non-human primates, we modulated cerebral perfusion pressure beyond the limits of autoregulation. Cerebral blood flow and volume were measured with diffuse correlation spectroscopy and near-infrared spectroscopy, respectively. <i>Results:</i> We show that impedance can be used to identify the lower and upper limits of autoregulation. <i>Conclusions:</i> This impedance method may be an alternative method to measure autoregulation and a way of assessing cerebral health non-invasively at the clinical bedside.
ChemInform Abstract: Preparation of Macrocyclic Di‐ and Tetraamides Containing Unsubstituted Macroring Nitrogen Atoms, Tertiary Amine Sidearms and/or Piperazine Subcyclic Units. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Bloom of Perovskite Optoelectronics: Fundamental Science Matters (2019)

Elsevier’s Scopus, the largest abstract and citation database of peer-reviewed literature. Search and access research from the science, technology, medicine, social sciences and arts and humanities fields.
On Single-User Interactive Beam Alignment in Next Generation Systems: A Deep Learning Viewpoint (2021)

Communication in high frequencies such as millimeter wave and terahertz suffer from high path-loss and intense shadowing which necessitates beamforming for reliable data transmission. On the other hand, at high frequencies the channels are sparse and consist of few spatial clusters. Therefore, beam alignment (BA) strategies are used to find the direction of these channel clusters and adjust the width of the beam used for data transmission. In this work, a single-user uplink scenario where the channel has one dominant cluster is considered. It is assumed that the user transmits a set of BA packets over a fixed duration. Meanwhile, the base-station (BS) uses different probing beams to scan different angular regions. Since the BS measurements are noisy, it is not possible to find a narrow beam that includes the angle of arrival (AoA) of the user with probability one. Therefore, the BS allocates a narrow beam to the user which includes the AoA of the user with a predetermined error probability while minimizing the expected beamwidth of the allocated beam. Due to intractability of this noisy BA problem, here this problem is posed as an end-to-end optimization of a deep neural network (DNN) and effects of different loss functions are discussed and investigated. It is observed that the proposed DNN based BA, at high SNRs, achieves a performance close to that of the optimal BA when there is no-noise and for all SNRs, outperforms state-of-the-art.
Hormonal Effects of Single Gonadotropin-Releasing Hormone Antagonist Doses in Men* (1988)

To assess its gonadotropin-inhibiting potency in man, three different doses of a GnRH antagonist [( Ac-D2-Nal1,D4-Cl-Phe2, D3-Pal3, Arg5,D4-p-methoxybenzoyl-2-amino butyric acid6,D-Ala10]GnRH; Nal-Glu GnRH antagonist) were given to six normal men. Single sc doses of 0.5, 1.5, and 5.0 mg Nal-Glu GnRH decreased mean serum immunoactive LH (iLH) to 45.0 +/- 5.7% (+/- SE), 37.0 +/- 4.9%, and 31.3 +/- 4.2% of baseline, respectively. Maximal suppression occurred between 4 and 8 h after drug injection. Serum bioassayable LH concentrations significantly diminished 8 h after injection of 1.5 and 5.0 mg GnRH antagonist, but not after the 0.5-mg dose. Mean serum testosterone (T) fell to 39.8 +/- 5.0%, 32.1 +/- 4.9%, and 20.7 +/- 4.4% of baseline, respectively, after the 0.5-, 1.5-, and 5.0-mg doses. The decreases in serum iLH and testosterone (T) were more sustained after the higher doses; serum iLH and T were significantly suppressed 24 h after administration of the 5.0-mg dose. Twenty-four-hour integrated serum iLH and T concentrations decreased in a dose-dependent manner. However, basal and 24-h integrated serum FSH concentrations were not significantly affected by the drug. No adverse systemic side-effects occurred. Thus, the Nal-Glu GnRH antagonist effectively decreases serum LH and T concentrations in a dose- and time-dependent manner, and it, therefore, has potential as a male contraceptive.
Crossover/Veering in V-Shaped MEMS Resonators (2021)

We investigate experimentally and theoretically mode crossing and mode veering between the first two symmetric and anti-symmetric modes of an electrothermally and electrostatically actuated in-plane V-shaped micro-beam. The micro-beam is sandwiched between four electrodes to electrostatically activate both modes of vibrations and to offer various actuation options. When tuning the electrothermal voltage, the natural frequencies of the two modes approach each other until they cross. Under an asymmetrical electrostatic actuation, it is shown experimentally that the system undergoes a transition between modes crossing to veering. In addition, an analytical study is presented based on a Galerkin-based reduced-order model of a nonlinear Euler&#x2013;Bernoulli shallow arch beam equation. The analytical results are compared to experimental data showing excellent agreement. The effects of the shape profile, Cosine and Arc, and micro-beam length are theoretically investigated on the transition between the crossing and veering behavior for the first four vibration modes. [2021-0223]
Using the Emulab network testbed to evaluate the Armada I/O framework for computational grids (2002)

Armada [OK02a, OK02b] is a framework for building dataintensive applications for large-scale computational grids. In Armada, a graph of processing modules describe data distribution, application interfaces, and processing required of
A Wide Input Voltage Range LLC Converter with Multi-mode Operations (2020)

In this paper, a novel LLC resonant converter with multi-mode operation rectifiers is proposed to regulate the wide low voltage range photovoltaic panel and to connect the panel to the high voltage DC bus. The proposed converter can operate in three modes of operation: as a voltage-doubler rectifier (VDR), as a voltage-tripler rectifier (VTR), and as a voltage fifthfolder rectifier (VFR). Therefore, the proposed converter covers a wide voltage range by automatically changing the rectifier structure. The three operation modes keep the switching frequency range close to the resonant frequency resulting in increased performance efficiency. The benefits of this topology include improved efficiency and a narrow switching frequency range. Moreover, zero-voltage-switching (ZVS) and zero-current-switching (ZCS) are achieved in all power MOSFETs and power diodes. A 250 W LLC resonant converter for wide input voltage was designed and simulated to verify the theoretical analysis and the circuit functionality.
Figure 2 from Somatic Mosaic Chromosomal Alterations and Death of Cardiovascular Disease Causes among Cancer Survivors (2023)

&lt;p&gt;Multivariable Cox regression models evaluating the effect of mCAs on death of CVD causes, of CAD causes, from cancer, and death of any cause. All models are adjusted for age at baseline, sex, smoking status, chemotherapy, radiotherapy, number of days between the date of recruitment and the date of cancer diagnosis, and principal components 1 to 10. Ref., referent category (1.0).&lt;/p&gt;
Autothermal Methane Oxidative Coupling Process over La2O3/MgO Catalysts (2015)

Abstract Some essential conditions necessary to reach an autothermal regime in methane oxidative coupling on La 2 O 3 /MgO catalysts were investigated. The following three ways can be suggested to transfer the process into the autothermal regime: (1) higher initial concentrations of reagents; (2) larger reactor diameter; (3) optimization of the flow rate and the preheating temperature. It was found that the optimal temperature of the autothermal regime of methane oxidative coupling is governed by the nature of the catalyst.
Transgenic Forsythia plants expressing sesame cytochrome P450 produce beneficial lignans (2022)

Lignans are widely distributed plant secondary metabolites that have received attention for their benefits to human health. Sesamin is a furofran lignan that is conventionally extracted from Sesamum seeds and shows anti-oxidant and anti-inflammatory activities in the human liver. Sesamin is biosynthesized by the Sesamum-specific enzyme CYP81Q1, and the natural sources of sesamin are annual plants that are at risk from climate change. In contrast, Forsythia species are widely distributed perennial woody plants that highly accumulate the precursor lignan pinoresinol. To sustainably supply sesamin, we developed a transformation method for Forsythia leaf explants and generated transgenic Forsythia plants that heterologously expressed the CYP81Q1 gene. High-performance liquid chromatography (HPLC) and LC-mass spectrometry analyses detected sesamin and its intermediate piperitol in the leaves of two independent transgenic lines of F. intermedia and F. koreana. We also detected the accumulation of sesamin and piperitol in their vegetatively propagated descendants, demonstrating the stable and efficient production of these lignans. These results indicate that CYP81Q1-transgenic Forsythia plants are promising prototypes to produce diverse lignans and provide an important strategy for the cost-effective and scalable production of lignans.
Risk-Loss Coordinated Admissibility Assessment of Wind Generation for Integrated Electric-Gas Systems (2020)

Due to the widely deployment of gas-fired units and the emerging power-to-gas (P2G) technologies, the interdependencies between power systems and gas systems have been enhanced, yet the impacts on the ability of accommodating the uncertain and variable wind generation are unclear. On one hand, the regulation capability of gas-fired units might be restricted due to pipeline congestion or gas supply shortage; on the other hand, the P2G facilities could operate as interruptible electrical loads to enhance the operational flexibility of the power network. This paper aims to revisit the wind generation admissibility assessment problem in view of integrated electric-gas systems. The overall model is established according to the two-stage robust optimization framework. By introducing the stepwise penalty coefficients for power shortage and surplus, the risk preference of the operator can be reflected. The mixed integer linear programming-based approximation methods is adopted to tackle the computational challenging Weymouth equation in the gas network, which requires an additional column-and-constraint (C&CG) loop to solve the second-stage max-min problem, other than the common one to coordinate the first- and second-stage problems, resulting in a nested C&CG algorithmic structure. The effectiveness of the proposed model and solution methods are validated by the simulation results.
The Ballistic Resonance: plasmonic response across IR with III-V semiconductors (2021)

We analyze the perspectives of the ballistic resonance to enable plasmonic and hyperbolic optical response of doped III-V semiconductors across the infrared frequency range. We demonstrate, experimentally and theoretically, plasmonic structures between 3-5 μn.
Neurogenic plasma leakage in mouse airways (1999)

1. This study sought to determine whether neurogenic inflammation occurs in the airways by examining the effects of capsaicin or substance P on microvascular plasma leakage in the trachea and lungs of male pathogen-free C57BL/6 mice. 2. Single bolus intravenous injections of capsaicin (0.5 and 1 micromol kg(-1), i.v.) or substance P (1, 10 and 37 nmol kg(-10, i.v.) failed to induce significant leakage in the trachea, assessed as extravasation of Evans blue dye, but did induce leakage in the urinary bladder and skin. 3. Pretreatment with captopril (2.5 mg kg(-1), i.v.), a selective inhibitor of angiotensin converting enzyme (ACE), either alone or in combination with phosphoramidon (2.5 mg kg(-1), i.v.), a selective inhibitor of neutral endopeptidase (NEP), increased baseline leakage of Evans blue in the absence of any exogenous inflammatory mediator. The increase was reversed by the bradykinin B2 receptor antagonist Hoe 140 (0.1 mg kg(-1), i.v.). 4. After pretreatment with phosphoramidon and captopril, capsaicin increased the Evans blue leakage above the baseline in the trachea, but not in the lung. This increase was reversed by the tachykinin (NK1) receptor antagonist SR 140333 (0.7 mg kg(-1), i.v.), but not by the NK2 receptor antagonist SR 48968 (1 mg kg(-1), i.v.). 5. Experiments using Monastral blue pigment as a tracer localized the leakage to postcapillary venules in the trachea and intrapulmonary bronchi, although the labelled vessels were less numerous in mice than in comparably treated rats. Blood vessels of the pulmonary circulation were not labelled. 6. We conclude that neurogenic inflammation can occur in airways of pathogen-free mice, but only after the inhibition of enzymes that normally degrade inflammatory peptides. Neurogenic inflammation does not involve the pulmonary microvasculature.
Ketoconazole potentiates terfenadine‐induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity (2002)

Terfenadine (TF) is a highly potent histamine H1 receptor antagonist that in clinically effective doses is free of significant central nervous system side effects. Ketoconazole (KT) is a worldwide used oral antifungal agent with a broad spectrum of activity against both superficial and systemic mycosis. Simultaneously administration of KT and TF has been reported to induce several potent symptoms including cardiotoxicity, excitotoxicity, inhibition of blood mononuclear cells proliferation, and cardiovascular toxicity. However, the intracellular molecular mechanisms of TF-KT interactions in cells were still uncertain. In this study, we first demonstrated that TF (5-30 microM) induced apoptosis in several types of human cancer cell lines including human hepatoma (Hep G2), colorectal cancer (COLO 205), and fibroblast (CCD 922SK) cells for 24 h. The cellular responses to TF-induced apoptosis were demonstrated to be associated with the p53-signaling pathway, including induction of p53, p21/Cip1, p27/Kip1, bax protein expression and inhibition of bcl-2 protein expression. To realized the role of H1 receptor involved in TF-induced apoptosis, different H1 receptor antagonists including promethazine, mequitazine, and chlorpheniramin (50-100 microM) were administered and demonstrated that these chemicals cannot induced apoptosis through the H1 receptor signaling pathway. Interestingly, we found that the apoptotic effect of TF (2.5 microM) was significantly potentiated by KT (1 microM) treatment in Hep G2 cells through inhibition of the cytochrome p450 3A4 (CYP 3A4) activity. Such results were demonstrated by decreased of the TF activity with recombinant CYP 3A4, which prepared from baculovirus-infected insect cells. Our results provide the molecular basis of TF-KT interaction and this information should allow more rational forecasting of the risk for TF therapy during co-administration of KT.
Tutorial: Color Rendering and Its Applications in Lighting (2015)

This tutorial explains how the human perception of color rendering arises, in terms of the underlying phenomena of light and vision, and using those concepts it presents a clear explanation of the CIE Color Rendering Index. The strengths and weaknesses of the CIE Color Rendering Index are reviewed and some common misunderstandings about color rendering are addressed. It is suitable for self-study, with learning outcomes stated at the beginning and a conceptual summary provided at the end.
Interleukin-1 and the Pathogenesis of the Acute-Phase Response (1984)

MICROBIAL invasion, tissue injury, immunologic reactions, and inflammatory processes induce a constellation of host responses collectively referred to as the acute-phase response. The response is characterized by changes in metabolic, endocrinologic, neurologic, and immunologic functions. Most of these changes are observed within hours or days after the onset of infection or inflammation, although many acute-phase changes also indicate persistent disease. The full spectrum of the response includes dramatic increases in the synthesis of hepatic acute-phase proteins, which contribute to elevated erythrocyte-sedimentation rates. Leukocytosis is commonly seen with increased numbers of circulating immature neutrophils; serum iron and zinc levels are depressed, . . .
Crank-Slider With Spring Constant Force Mechanism (2004)

This paper explores the development and performance of new constant-force compliant mechanisms that involve the addition of a translational spring element to slider-crank constant force mechanisms. The translational spring element has the additional requirement that, similar to a slider, it resists off-axis loads sufficiently to permit translation along only one axis. Geometric and energy storage parameters have been determined by optimization for five classes of mechanisms. The results of the optimization are values for geometric and energy storage parameters for each mechanism class for various levels of the translational spring parameter and various levels of constant-force behavior. The new configurations experience decreasing performance with increasing translational spring stiffness. The potential to implement a translational spring that also acts as a slider link provides the motivation for the new configurations. Such a spring would have the potential to completely remove friction from the mechanism and provide a constant-force solution that could replace current solutions such as hydraulic or pneumatic devices. The new configurations also have the potential to be manufactured as one piece or in layers, opening up new arenas for compressive constant-force mechanisms. Prototyping and testing of one of the new configurations are included as an example to demonstrate the use of the behavioral model.
HIV-1 Receptor Binding Site-Directed Antibodies Using a VH1-2 Gene Segment Orthologue Are Activated by Env Trimer Immunization (2014)

Broadly neutralizing antibodies (bNAbs) isolated from chronically HIV-1 infected individuals reveal important information regarding how antibodies target conserved determinants of the envelope glycoprotein (Env) spike such as the primary receptor CD4 binding site (CD4bs). Many CD4bs-directed bNAbs use the same heavy (H) chain variable (V) gene segment, VH1-2*02, suggesting that activation of B cells expressing this allele is linked to the generation of this type of Ab. Here, we identify the rhesus macaque VH1.23 gene segment to be the closest macaque orthologue to the human VH1-2 gene segment, with 92% homology to VH1-2*02. Of the three amino acids in the VH1-2*02 gene segment that define a motif for VRC01-like antibodies (W50, N58, flanking the HCDR2 region, and R71), the two identified macaque VH1.23 alleles described here encode two. We demonstrate that immunization with soluble Env trimers induced CD4bs-specific VH1.23-using Abs with restricted neutralization breadth. Through alanine scanning and structural studies of one such monoclonal Ab (MAb), GE356, we demonstrate that all three HCDRs are involved in neutralization. This contrasts to the highly potent CD4bs-directed VRC01 class of bNAb, which bind Env predominantly through the HCDR2. Also unlike VRC01, GE356 was minimally modified by somatic hypermutation, its light (L) chain CDRs were of average lengths and it displayed a binding footprint proximal to the trimer axis. These results illustrate that the Env trimer immunogen used here activates B cells encoding a VH1-2 gene segment orthologue, but that the resulting Abs interact distinctly differently with the HIV-1 Env spike compared to VRC01.
Pelvic retroversion: a compensatory mechanism for lumbar stenosis (2017)

OBJECTIVE The flexed posture of the proximal (L1-3) or distal (L4-S1) lumbar spine increases the diameter of the spinal canal and neuroforamina and can relieve symptoms of neurogenic claudication. Distal lumbar flexion can result in pelvic retroversion; therefore, in cases of flexible sagittal imbalance, pelvic retroversion may be compensatory for lumbar stenosis and not solely compensatory for the sagittal imbalance as previously thought. The authors investigate underlying causes for pelvic retroversion in patients with flexible sagittal imbalance. METHODS One hundred thirty-eight patients with sagittal imbalance who underwent a total of 148 fusion procedures of the thoracolumbar spine were identified from a prospective clinical database. Radiographic parameters were obtained from images preoperatively, intraoperatively, and at 6-month and 2-year follow-up. A cohort of 24 patients with flexible sagittal imbalance was identified and individually matched with a control cohort of 23 patients with fixed deformities. Flexible deformities were defined as a 10° change in lumbar lordosis between weight-bearing and non-weight-bearing images. Pelvic retroversion was quantified as the ratio of pelvic tilt (PT) to pelvic incidence (PI). RESULTS The average difference between lumbar lordosis on supine MR images and standing radiographs was 15° in the flexible cohort. Sixty-eight percent of the patients in the flexible cohort were diagnosed preoperatively with lumbar stenosis compared with only 22% in the fixed sagittal imbalance cohort (p = 0.0032). There was no difference between the flexible and fixed cohorts with regard to C-2 sagittal vertical axis (SVA) (p = 0.95) or C-7 SVA (p = 0.43). When assessing for postural compensation by pelvic retroversion in the stenotic patients and nonstenotic patients, the PT/PI ratio was found to be significantly greater in the patients with stenosis (p = 0.019). CONCLUSIONS For flexible sagittal imbalance, preoperative attention should be given to the root cause of the sagittal misalignment, which could be compensation for lumbar stenosis. Pelvic retroversion can be compensatory for both the lumbar stenosis as well as for sagittal imbalance.
NF-kappa B protein purification from bovine spleen: nucleotide stimulation and binding site specificity. (1988)

The activity of the enhancer for the kappa immunoglobulin light chain gene critically depends on the presence in the nucleus of the NF-kappa B protein. We purified NF-kappa B over 50,000-fold and identified two protein species, 42 and 44 kDa, that could be eluted and renatured from a sodium dodecyl sulfate/polyacrylamide gel to give specific DNA-binding activity. Binding of the purified bovine NF-kappa B as well as that from human and murine B- or T-lymphoid cell extracts was dramatically stimulated by nucleoside triphosphates. This effect distinguished NF-kappa B from a related factor, H2-TF1. Purified NF-kappa B interacted efficiently with regulatory sequences that function during either B- or T-lymphocyte activation, including the human immunodeficiency virus enhancer and a NF-kappa B binding site we detected in the interleukin 2 enhancer.
Supplementary Figure Legend from Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis (2023)

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