gebhart/patrepeval huggingface dataset:
Stability of Sodium Electrodeposited from a Room Temperature Chloroaluminate Molten Salt (1995)

Room temperature molten salts consisting of 1‐methyl‐3‐ethylimidazolium chloride (MEIC) and aluminum chloride have been examined as possible electrolytes for a room temperature design of the sodium/iron(II) chloride battery. This work examines the conditions required to achieve efficient reduction and oxidation of sodium from a sodium chloride buffered, neutral melt. Two substrates were examined, tungsten and 303 stainless steel, using both cyclic voltammetry and chronopotentiometry. Melts were protonated using a closed electrochemical cell to allow quantification of the effect of dissolved on the efficiency of the sodium couple. A threshold of approximately 6 Torr partial pressure was observed for sodium plating‐stripping. Below this threshold, the sodium couple was not observed. The results show that the sodium plating‐stripping efficiency increases with increasing current density; however, the efficiency reaches a maximum and is adversely affected by high overpotentials and extended exposure of the sodium to the melt. It appears that some passivation occurs as even a very thin layer of plated sodium exhibits a steady open‐circuit voltage over long periods in the melt.
Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands (2018)

A new family of melatonin receptor ligands, characterized by a tetrahydroquinoline (THQ) scaffold carrying an amide chain in position 3, was devised as conformationally constrained analogs of flexible N-anilinoethylamides previously developed. Molecular superposition models allowed to identify the patterns of substitution conferring high receptor binding affinity and to support the THQ ring as a suitable scaffold for the preparation of melatonin ligands. The biological activity of 3-acylamino-THQs was compared with that of the corresponding tetralin derivatives. The THQ ring proved to be a versatile scaffold for easy feasible MT<sub>1</sub> and MT<sub>2</sub> ligands, which resulted as more polar bioisosteres of their tetralin analogs. Potent partial agonists, with subnanomolar binding affinity for the MT<sub>2</sub> receptor, were obtained, and a new series of THQ derivatives is presented. The putative binding mode of potent THQs and tetralines was discussed on the basis of their conformational equilibria as inferred from molecular dynamics simulations and experimental NMR data.
SURFACE AND STRUCTURAL CHARACTERIZATION OF CuInS2 THIN FILMS DEPOSITED BY ONE-STAGE RF REACTIVE SPUTTERING (2002)

CuInS 2 films were deposited on float glass substrates by a one-stage reactive RF sputter process using a Cu-In alloy target and H 2 S gas. The sputtered films generally have a (112) preferential orientation. X-ray reflectometry was used to measure the thickness, surface density as well as surface roughness of the sputtered films. The surface morphology of the films was studied by scanning electron microscopy. Energy-dispersive X-ray analysis was performed to determine the composition of the films. XPS revealed that the film surfaces remain In-rich with respect to the bulk.
Impingement type micro fluidic device using electro-conjugate fluid (2012)

An electro-conjugate fluid (ECF) is a kind of dielectric fluid which produces a strong jet flow (ECF jet) when subjected to high DC voltage. Namely, a pair of electrodes generates nonuniform electric field, which induces the ECF jet. It is known that some kinds of ECF may possibly produce an impingement jet which occurs between electrodes. This study proposes an impingement type micro fluidic device whose power source is integrated by using the ECF. We developed a prototype and confirmed our concept.
The Barrow Ruptured Aneurysm Trial: 3-year results (2013)

Based on mRS scores at 3 years, the outcomes of all patients assigned to coil embolization showed a favorable 5.8% absolute difference compared with outcomes of those assigned to clip occlusion, although this difference did not reach statistical significance (p=0.25). Patients in the clip group had a significantly higher degree of aneurysm obliteration and a significantly lower rate of recurrence and retreatment. In post hoc analysis examining only anterior circulation aneurysms, no outcome difference between the 2 treatment cohorts was observed at any recorded time point. CLINICAL TRIAL REGISTRATION NO.: NCT01593267 ( ClinicalTrials.gov ).
Quantitative trait loci for β‐conglycinin (7S) and glycinin (11S) fractions of soybean storage protein (2004)

Abstract Glycinin (11S) and β‐conglycinin (7S) are important seed storage proteins in soybean [ Glycine max (L.) Merr.]. A major limitation of soybean seed storage proteins is their low levels of the sulfur‐containing amino acids, methionine and cysteine, which are important nutritional components of protein mea. Glycinin contains significantly more S‐containing amino acids than does β‐conglycinin. Thus, detection of quantitative trait loci (QTL) that govern 11S may provide marker‐assisted selection (MAS) opportunities to improve soybean total S‐containing amino acids. The objective of this study was to detect and map QTL governing 7S and 11S fractions of soybean seed storage proteins. To achieve this objective, 101 F 6 ‐derived recombinant inbred lines (RIL) developed from a cross of N87‐984‐16 ×TN93‐99 were used. Storage proteins were extracted from all RIL and separated in 10–20% linear gradient polyacrylamide gels. Dried gels were scanned for individual subunits of storage protein with a densitometer equipped with a He−Ne laser light source. Data were converted to concentration for each subunit component and analyzed using SAS software. A significant ( P &lt;0.05) difference among genotypes was found for glycinin and β‐conglycinin. A total of 94 polymorphic simple sequence repeat molecular genetic markers were used in screening all RIL. Three QTL for glycinin (Satt461, Satt292, and Satt156) were distributed on linkage group (LG) D2, I, and L, respectively, whereas two QTL for conglycinin (Satt461 and Satt249) were distributed on LG D2 and J. Phenotypic variation explained by individual QTL ranged from 9.5 to 22%. These QTL may provide useful MAS opportunities for improvement of nutritional quality in soybean.
Disambiguation of optic flow with vestibular signals (2010)

Optic flow is generated by observer motion relative to stationary objects, by movement of objects relative to a stationary observer, and by combinations of those situations. To determine the relative contributions of object and self motion to the observed optic flow, the nervous system can use vestibular signals. An object's speed relative to earth is given by the difference between its speed relative to the head and the head's speed relative to the earth. The variance of the difference is the sum of the component variances: σ2obj=σ2vis+σ2vest. In contrast, if observers estimate self-motion from optic flow and vestibular signals, and assume a stationary visual scene, visual and vestibular estimates may be combined in a weighted average to yield more precise self-motion estimates: σ2self=(σ2visσ2vest)/(σ2vis+σ2vest). So depending on whether the subject reports object motion or self-motion, the two-modality variance is predicted to be respectively higher or lower than the component variances. To test these predictions, we measured speed-discrimination thresholds for fore-aft translations and roll rotations. There were two single-modality conditions, Visual and Vestibular, and two multi-modality conditions, Self-motion and Object-motion. In the Visual, Vestibular, and Self-motion conditions, observers indicated if the movement was faster or slower than a standard. In the Object-motion condition, observers indicated if the object appeared to move with or against the self-motion. Experiments were conducted on a rotating chair and translating motion platform. The stereoscopic projection system was mounted on the apparatus. Stimuli were random-dot planes that rotated clockwise or anti-clockwise or translated forwards or backwards. In the translation conditions, multi-modal object-motion thresholds were, as predicted, higher than single-modality thresholds, and multi-modal self-motion thresholds were, as predicted, generally lower than single-modality thresholds. Results from the rotation conditions were less clear. Possible causes of differing results for translations and rotations will be discussed.
Quantitative and Theoretical Analysis of PHB-Hole Feature under Applying Electric Field. (1992)

We have investigated the stark effect on the spectral hole characteristics in the photochemical hole burning systems of anthraquinone derivatives, such as, 1,4-dihydroxyanthraquinone (HAQ) and 4-amino-2,6-bis(4-butylphenoxy)1,5-dihydroxyanthraquinone (ABDAQ) as guest molecules embedded in host polymers such as 2-hydroxyethyl methacrylate (PHEMA) or poly(vinyl butyral) (PVB) 1-3) . Consequently, we evaluated the dipole moment differences |δμ| of guest molecules. These dipole moment differences depended on the characteristics of the guest and host molecules. This material dependence of the dipole moment differences was able to be explained qualitatively by Hammett’s substituent constant and the Taft’s polar substituent constant 3) .
Hybrid Techniques for High-Fidelity Physical Simulation of Solids and Fluids (2008)

This dissertation presents hybrid algorithms for the simulation of fluids and solids as well as methods for coupling between the two. Physical simulations have become prevelant in computer graphics due to their ability to predict phenomena with too many degrees of freedom for hand animation. Nevertheless, it has been challenging to obtain simulations with sufficiently high quality in a reasonable amount of time, leading to the development of a large variety of geometric representations and simulation algorithms, each suited to a particular class of problems. While this makes choosing and implementing simulation technology difficult, this diversity of techniques results from attempts to balance tradeoffs. This suggests that increased simulation fidelity and efficiency can be obtained by synthesizing hybrid techniques, and this thesis presents examples of such techniques. In addition to algorithmic improvements we also consider the use of distributed memory parallelism (MPI) to improve the tractability of highly detailed simulations.
In the first chapters, we concentrate on increasing the fidelity of fluids by reducing numerical dissipation. Truncation error in the solution of the hyperbolic advection equation is reduced by a new unconditionally stable advection method. Two semi-Lagrangian advection steps are combined to obtain second-order accuracy in space and time while also providing a constructive reinterpretation of MacCormack's advection method. To reduce dissipation in smoke, water and explosions, we also present a Lagrangian/Eulerian scheme that couples a Lagrangian vortex particle method with an Eulerian pressure-velocity method. Additionally, we consider coupling Lagrangian deformable and rigid thin shells to Eulerian fluid flows using robust ray casting, fully preventing fluid leaks across the thin boundary.
In the next chapters, we discuss simulation of solids using Lagrangian techniques. We introduce improved altitude springs for the simulation of volumetric tetrahedra, which we apply to bending in cloth and torsion in hair. We also introduce a simple mass-spring model for hair simulation that uses tetrahedral simulation techniques for simulating straight and curly strands of hair. For time integration we develop an unconditionally stable fully-implicit linear spring that can be included in a semi-implicit Newmark time integration scheme. For collisions and interactions, we develop a hybrid scheme that uses inexpensive history-based repulsions coupled with more accurate geometric collisions. We also present a method for obtaining accurate friction of deformable objects with collision bodies when a semi-implicit or fully-implicit time evolution approach is used.
Soldering MWT Solar Cells into Solar Modules (2014)

In this paper, we investigate an approach for the interconnection and module integration of MWT cells, based on stringing technology. The main difference with standard technology for stringing 2-side contacted cells is the additional layup of a woven glass fibre insulator to avoid shunting due to the stringing process. Compared to the integrated backsheet approach, we believe a stringing approach can have a much faster industrial take-up as it is much closer (in terms of process as well as equipment and materials, and therefore also costs) to the current widely adopted method for manufacturing PV modules (based on stringing and lamination of 2-side contacted cells). Next to this technology development and demonstration, we also want to indicate in this paper how inspection using electroluminescence may clearly help understanding and improving such development, by early on determining, understanding and pinpointing failures in a non-destructive way.
Soluble and particulate methane monooxygenase gene clusters in the marine methanotrophMethylomicrobiumsp. strain NI (2007)

Soluble methane monooxygenase (sMMO) and particulate methane monooxygenase (pMMO) gene clusters in the marine methanotroph Methylomicrobium sp. strain NI were completely sequenced and analysed. Degenerated primers were newly designed and used to amplify the gene fragments containing intergenic mmoX-Y and mmoD-C regions and a partial pmoC region. Phylogenetic analysis of amino acid sequences deduced from mmoX and pmoA, as well as of 16S rRNA gene sequences, indicated that this strain was most closely related to the halotolerant methanotroph Methylomicrobium buryatense. There were putative sigma(54)- and sigma(70)-dependent promoter sequences upstream of the sMMO and pMMO genes, respectively, and mmoG, which is known to be related to the expression and assembly of sMMO, existed downstream of the sMMO genes. These findings suggest that the major components and regulation of MMOs in this marine methanotroph are quite similar to those in freshwater methane oxidizers, despite the difference in their habitats.
LandScape: a simple method to aggregate p-values and other stochastic variables without a priori grouping (2016)

In many areas of science it is custom to perform many, potentially millions, of tests simultaneously. To gain statistical power it is common to group tests based on a priori criteria such as predefined regions or by sliding windows. However, it is not straightforward to choose grouping criteria and the results might depend on the chosen criteria. Methods that summarize, or aggregate, test statistics or p-values, without relying on a priori criteria, are therefore desirable. We present a simple method to aggregate a sequence of stochastic variables, such as test statistics or p-values, into fewer variables without assuming a priori defined groups. We provide different ways to evaluate the significance of the aggregated variables based on theoretical considerations and resampling techniques, and show that under certain assumptions the FWER is controlled in the strong sense. Validity of the method was demonstrated using simulations and real data analyses. Our method may be a useful supplement to standard procedures relying on evaluation of test statistics individually. Moreover, by being agnostic and not relying on predefined selected regions, it might be a practical alternative to conventionally used methods of aggregation of p-values over regions. The method is implemented in Python and freely available online (through GitHub, see the Supplementary information).
Clusterin regulates macrophage expansion, polarization and phagocytic activity in response to inflammation in the kidneys (2020)

Clusterin (CLU) is a multifunctional protein localized extracellularly and intracellularly. Although CLU-knockout (KO) mice are more susceptible to renal ischemia-reperfusion injury (IRI), the mechanisms underlying the actions of CLU in IRI are not fully understood. Macrophages are key regulators of IRI severity and tissue repair. Therefore, we investigated the role of CLU in macrophage polarization and phagocytosis. Renal IRI was induced in wild-type (WT) or CLU-KO C57BL/6 mice by clamping the renal pedicles for 30 min at 32°C. Peritoneal macrophages were activated via an intraperitoneal injection of lipopolysaccharide (LPS). Renal tissue damage was examined using histology, whereas leukocyte phenotypes were assessed using flow cytometry and immunohistochemistry. We found that monocytes/macrophages expressed the CLU protein that was upregulated by hypoxia. The percentages of macrophages (F4/80<sup>+</sup> , CD11b<sup>+</sup> or MAC3<sup>+</sup> ) infiltrating the kidneys of WT mice were significantly less than those in CLU-KO mice after IRI. The M1/M2 phenotype ratio of the macrophages in WT kidneys decreased at day 7 post-IRI when the injury was repaired, whereas that in KO kidneys increased consistently as tissue injury persisted. In response to LPS stimulation, WT mice produced fewer M1 macrophages, but not M2, than the control did. Phagocytosis was stimulated by CLU expression in macrophages compared with the CLU null controls and by the exogenous CLU protein. In conclusion, CLU suppresses macrophage infiltration and proinflammatory M1 polarization during the recovery period following IRI, and enhances phagocytic activity, which may be partly responsible for tissue repair in the kidneys of WT mice after injury.
Design and Optimization of Digital Signal Components Separator of LINC Transmitters Using FPGA Processors (2007)

This paper presents a comparative study of the performances of various digital signal components separator topologies for linear amplification using non linear components based transmitters. The topologies studied use different subcomponents to perform the most computationally demanding part of the digital signal components separator that is the calculation of the square root function. Three cases are considered: the square root function is implemented using a commercially available square root mega-function, a custom designed square root function, and a one dimensional look-up table. The measurement results show that all topologies achieve comparable throughput performances. However, the look-up table implementation reduces the computational complexity and improves the achievable accuracy.
Possible association of norepinephrine transporter -3081(A/T) polymorphism with methylphenidate response in attention deficit hyperactivity disorder (2010)

Our findings provide evidence for the involvement of the -3081(A/T) polymorphism of SLC6A2 in the modulation of the effectiveness of MPH treatment in ADHD.
Advances in Multimicrophone Speech Processing (2006)

1 School of Engineering, Bar-Ilan University, Ramat-Gan, 52900, Israel 2 INRS-EMT, University of Quebec, 800 de la Gauchetiere Ouest, Montreal, QC, Canada H5A 1K6 3 Institute of Audiology and Hearing Science, University of Applied Sciences, Oldenburg/Ostfriesland/Wilhelmshaven Ofener Street 16, 26121 Oldenburg, Germany 4Department of Electrical Engineering, Technion — Israel Institute of Technology, Technion City, Haifa 32000, Israel 5Department of Electrical Engineering (ESAT-SCD), Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, 3001 Leuven, Belgium 6 Institute of Communication Acoustics, Ruhr-Universitaet Bochum, 44780 Bochum, Germany 7Western Australian Telecommunications Research Institute, The University of Western Australia, 35 Stirling Hwy, Crawley, 6009, Australia
Green Light-Excitable Ce-Doped Nitridomagnesoaluminate Sr[Mg2Al2N4] Phosphor for White Light-Emitting Diodes (2016)

This work was supported by the Ministry of Science and Tech- nology of Taiwan (Contract Nos. MOST 104-2113-M-002-012- MY3, MOST 104-2119-M-002-027-MY3, MOST 104-2923-M- 002-007-MY3); the National Center for Research and Development Poland Grant (No. SL-TW2/8/2015). The contribution of S. M. was supported by the grant "Iuventus Plus" 0271/IP3/2015/73 from Ministry of Science and Higher Education, Poland, and the Russian Foundation for Basic Re- search (15-52-53080). The authors would also like to acknowledge the financial support from the Epistar Company.
Topical Ocular Sodium 4-Phenylbutyrate Rescues Glaucoma in a Myocilin Mouse Model of Primary Open-Angle Glaucoma (2012)

Topical ocular PBA reduces glaucomatous phenotypes in Tg-MYOC(Y437H) mice, most likely by reducing myocilin accumulation and ER stress in the TM. Topical ocular PBA could become a novel treatment for POAG patients with myocilin mutations.
Abstract 2352: Defining a pediatric cancer dependency map (2018)

Abstract Many children with metastatic or recurrent pediatric solid tumors continue to have poor survival, and there is an immense need to identify novel therapeutic approaches. Moreover, these cancers typically have simple genomes with limited known druggable molecular events. In order to discover new vulnerabilities in pediatric solid tumors, we have performed genome-scale CRISPR-Cas9 loss-of-function screening and deep “omic” characterization in over 60 pediatric cancer cell lines to date, including neuroblastoma, medulloblastoma, Ewing sarcoma, malignant rhabdoid tumor and rhabdomyosarcoma lines, to begin defining a pediatric cancer dependency map. Global analyses of the pediatric dependency landscape have identified emerging classes of pediatric cancers, including epigenetic-driven, aberrant transcription factor-driven and receptor tyrosine kinase-driven malignancies. For example, the preferential dependencies identified in a subset of neuroblastoma, which has aberrantly high expression of the transcription factor MYCN, are highly enriched for an interconnected network of genes annotated to have transcription factor activity. In addition to the global evaluation, we have developed methods and tools for prioritizing targets for further validation within a cancer type. These tools computationally integrate the pediatric dependency data across multiple datasets to identify categories of genetic dependencies that are especially strong hits or enriched hits in a specific pediatric malignancy. As an example, the intersection of MYCN-amplified neuroblastoma specific dependencies and H3-lysine 27 acetylation (H3K27ac) profiling across MYCN-amplified neuroblastoma allowed us to identify a transcriptional core regulatory circuit (CRC) that may drive the malignant state. Furthermore, targeting transcription with the BRD4 inhibitor JQ1 and CDK7 inhibitor THZ1 caused synergistic killing of neuroblastoma cells suggesting a novel therapeutic approach to treating this disease. Thus, defining a comprehensive pediatric cancer dependency map and developing the methods and tools to prioritize vulnerabilities in different cancer types will allow us to discover both novel biology and new therapeutic opportunities in childhood malignancies. Citation Format: Neekesh V. Dharia, Clare Malone, Amanda Balboni Iniguez, Lillian Guenther, Liying Chen, Gabriela Alexe, Adam D. Durbin, Mark W. Zimmerman, Andrew Hong, Pratiti Bandopadhayay, Mariella G. Filbin, Thomas Howard, Brenton Paolella, Iris Fung, Josephine Lee, Phil Montgomery, John M. Krill-Burger, Brian J. Abraham, Jennifer Roth, David E. Root, Richard A. Young, A. Thomas Look, Rameen Beroukhim, Jesse S. Boehm, William C. Hahn, Todd R. Golub, Aviad Tsherniak, Francisca Vazquez, Kimberly Stegmaier. Defining a pediatric cancer dependency map [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2352.