gebhart/patrepeval huggingface dataset:
2015: A New Impact Factor for ACS Chemical Neuroscience and New Topline Data for Global Pharmaceutical Products (2016)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXT2015: A New Impact Factor for ACS Chemical Neuroscience and New Topline Data for Global Pharmaceutical ProductsCraig W. LindsleyCite this: ACS Chem. Neurosci. 2016, 7, 7, 842–843Publication Date (Web):July 20, 2016Publication History Published online20 July 2016Published inissue 20 July 2016https://pubs.acs.org/doi/10.1021/acschemneuro.6b00177https://doi.org/10.1021/acschemneuro.6b00177editorialACS PublicationsCopyright © 2016 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views2276Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (139 KB) Get e-AlertscloseSUBJECTS:Chemical neuroscience,Hepatitis,Medicinal chemistry,Pharmaceuticals,Therapeutics Get e-Alerts
Solar energy storage reactions involving metal complexes (1980)

Photochemical properties of transition metal complexes are discussed as they relate to possible schemes for energy storage. Complexes of copper(I) with π-acceptor ligands have been used to sensitize isomerizations of organic molecules, and there is room for considerable further investigation in this area. Electron transfer reactions have been more intensively studied. These reactions fall into three broad categories: ionization, oxidative addition/reductive elimination, and excited state electron transfer. Experiments in the first two categories have generally led to rather poor storage efficiency and have required ultraviolet light. But long-lived excited states of coordination compounds can participate in chemical reactions with high efficiency, and such systems are promising for solar energy storage. Specific systems of this type that are discussed in detail involve electron transfer quenching of the lowest emissive excited states of Ru(2, 2‘-bipyridine)23+M2 (diisocyanoalkane)2+4(M=Rh, Ir), and Mo6cl2-14. © IUPAC
Optimization of the performances of MESFET based microwave amplifiers using Plackett-Burman design of experiment (2002)

This paper presents a method for the efficient determination of the optimum operation conditions for MESFET based microwave amplifiers. It has been found that the regression analysis performed on data gathered according to Plackett-Burman designs of experiment (DOE) lead to the determination of the optimal operating conditions of the device. Experimental data have validated the proposed strategy, which also contributed to reducing the total duration of the experimentation. After 4 iterations of the process, we found the optimal operation for either power output, transducer gain or drain efficiency. No equivalent circuit model was needed for this analysis and the method was proved efficient even if the transistor has been operated in a strongly nonlinear mode.
Trophic factor induction of human umbilical cord blood cellsin vitroandin vivo (2007)

The mononuclear fraction of human umbilical cord blood (HUCBmnf) is a mixed cell population that multiple research groups have shown contains cells that can express neural proteins. In these studies, we have examined the ability of the HUCBmnf to express neural antigens after in vitro exposure to defined media supplemented with a cocktail of growth and neurotrophic factors. It is our hypothesis that by treating the HUCBmnf with these developmentally-relevant factors, we can expand the population, enhance the expression of neural antigens and increase cell survival upon transplantation. Prior to growth factor treatment in culture, expression of stem cell antigens is greater in the non-adherent HUCBmnf cells compared to the adherent cells (p < 0.05). Furthermore, treatment of the non-adherent cells with growth factors, increases BrdU incorporation, especially after 14 days in vitro (DIV). In HUCBmnf-embryonic mouse striata co-culture, a small number of growth factor treated HUCBmnf cells were able to integrate into the growing neural network and express immature (nestin and TuJ1) and mature (GFAP and MAP2) neural markers. Treated HUCBmnf cells implanted in the subventricular zone predominantly expressed GFAP although some grafted HUCBmnf cells were MAP2 positive. While short-term treatment of HUCBmnf cells with growth and neurotrophic factors enhanced proliferative capacity in vitro and survival of the cells in vivo, the treatment regimen employed was not enough to ensure long-term survival of HUCBmnf-derived neurons necessary for cell replacement therapies for neurodegenerative diseases.
A 2.5 pJ/b Binary Image Sensor as a Pathfinder for Quanta Image Sensors (2015)

This paper presents a pathfinder binary image sensor for exploring low-power dissipation needed for future implementation of gigajot single-bit quanta image sensor (QIS) devices. Using a charge-transfer amplifier design in the readout signal chain and pseudostatic clock gating units for row and column addressing, the 1-Mpixel binary image sensor operating at 1000 frames/s dissipates only 20-mW total power consumption, including I/O pads. The gain and analog-to-digital converter stages together dissipate 2.5 pJ/b, successfully paving the way for future gigajot QIS sensor designs.
MiR-181b sensitizes glioma cells to teniposide by targeting MDM2 (2014)

MiR-181b is an important positive regulator on glioma cell sensitivity to teniposide. It confers glioma cell sensitivity to teniposide through binding to the 3'-UTR region of MDM2 leading to its reduced expression. Our findings not only reveal the novel mechanism involved in teniposide resistance, but also shed light on the optimization of glioma treatment in the future.
Intuitive control of a planar bipedal walking robot (2002)

Bipedal robots are difficult to analyze mathematically. However, successful control strategies can be discovered using simple physical intuition and can be described in simple terms. Five things have to happen for a planar bipedal robot to walk. Height has to be stabilized. Pitch has to be stabilized. Speed has to be stabilized. The swing leg has to move so that the feet are in locations which allow for the stability of height, pitch, and speed. Finally, transitions from support leg to support leg must occur at appropriate times. If these five objectives are achieved, the robot will walk. A number of different intuitive control strategies can be used to achieve each of these five objectives. Further, each strategy can be implemented in a variety of ways. We present several strategies for each objective which we have implemented on a bipedal walking robot. Using these simple intuitive strategies, we have compelled a seven link planar bipedal robot, called Spring Flamingo, to walk. The robot walks both slowly and quickly, walks over moderate obstacles, starts, and stops.
Hydrogen Clathrates: Next Generation Hydrogen Storage Materials (2021)

Extensive research has been carried on the molecular adsorption in high surface area materials such as carbonaceous materials and MOFs as well as atomic bonded hydrogen in metals and alloys. Clathrates stand among the ones to be recently suggested for hydrogen storage. Although, the simulations predict lower capacity than the expected by the DOE norms, the additional benefits of clathrates such as low production and operational cost, fully reversible reaction, environmentally benign nature, low risk of flammability make them one of the most promising materials to be explored in the next decade. The inherent ability to tailor the properties of clathrates using techniques such as addition of promoter molecules, use of porous supports and formation of novel reverse micelles morphology provide immense scope customisation and growth. As rapidly evolving materials, clathrates promise to get as close as possible in the search of “holy grail” of hydrogen storage. This review aims to provide the audience with the background of the current developments in the solid-state hydrogen storage materials, with a special focus on the hydrogen clathrates. The in-depth analysis of the hydrogen clathrates will be provided beginning from their discovery, various additives utilised to enhance their thermodynamic and kinetic properties, challenges in the characterisation of hydrogen in clathrates, theoretical developments to justify the experimental findings and the upscaling opportunities presented by this system. The review will present state of the art in the field and also provide a global picture for the path forward.
Exploiting Prunability for Person Re-Identification (2019)

Recent years have witnessed a substantial increase in the deep learning (DL)architectures proposed for visual recognition tasks like person re-identification,where individuals must be recognized over multiple distributed cameras. Althoughthese architectures have greatly improved the state-of-the-art accuracy, thecomputational complexity of the CNNs commonly used for feature extractionremains an issue, hindering their deployment on platforms with limited resources,or in applications with real-time constraints. There is an obvious advantage toaccelerating and compressing DL models without significantly decreasing theiraccuracy. However, the source (pruning) domain differs from operational (target)domains, and the domain shift between image data captured with differentnon-overlapping camera viewpoints leads to lower recognition accuracy. In thispaper, we investigate the prunability of these architectures under different designscenarios. This paper first revisits pruning techniques that are suitable forreducing the computational complexity of deep CNN networks applied to personre-identification. Then, these techniques are analysed according to their pruningcriteria and strategy, and according to different scenarios for exploiting pruningmethods to fine-tuning networks to target domains. Experimental resultsobtained using DL models with ResNet feature extractors, and multiplebenchmarks re-identification datasets, indicate that pruning can considerablyreduce network complexity while maintaining a high level of accuracy. Inscenarios where pruning is performed with large pre-training or fine-tuningdatasets, the number of FLOPS required by ResNet architectures is reduced byhalf, while maintaining a comparable rank-1 accuracy (within 1% of the originalmodel). Pruning while training a larger CNNs can also provide a significantlybetter performance than fine-tuning smaller ones.
Agonists at the Serotonin Receptor (5-HT1A) Protect the Retina from Severe Photo-Oxidative Stress (2010)

5-HT(1A) agonists provided potent and complete functional and structural protection. Protection was inhibited by treatment with WAY-100635, confirming the requirement for activating the 5-HT(1A) receptor in initiating this survival pathway. Single-dose experiments with AL-8309A suggest that the mechanism of protection is rapidly activated and protection persists for 48 hours. AL-8309B (1.75%) was effective after topical ocular dosing. AL-8309B is under evaluation in the clinic and may be useful in treating age-related macular degeneration.
Figure S4 from TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer (2023)

&lt;p&gt;L2 CAR T cells provide a survival advantage and disrupt vessels and tumor architecture in TNBC xenografts .&lt;/p&gt;
Phosphorylation of Bovine Herpesvirus 1 VP8 Plays a Role in Viral DNA Encapsidation and Is Essential for Its Cytoplasmic Localization and Optimal Virion Incorporation (2016)

In this study, phosphorylation of VP8 was shown to have a function in BoHV-1 replication. A virus containing a mutated VP8 protein that is not phosphorylated by CK2 and US3 (BoHV-1-YmVP8) produced smaller numbers of infectious virions than wild-type (WT) virus. The maturation and egress of WT and mutant BoHV-1 were studied, showing a process similar to that reported for other alphaherpesviruses. Interestingly, lack of phosphorylation of VP8 by CK2 and US3 resulted in reduced incorporation of viral DNA into capsids during mutant BoHV-1 infection, as well as lower numbers of extracellular virions. Furthermore, mutant VP8 remained nuclear throughout infection, in contrast to WT VP8, which is nuclear at early stages and Golgi apparatus associated late during infection. This correlates with smaller amounts of mutant VP8 in virions and suggests for the first time that VP8 may be assembled into the virions at two stages, with the latter dependent on phosphorylation.
Improvement of electron mobility in La:BaSnO3 thin films by insertion of an atomically flat insulating (Sr,Ba)SnO3 buffer layer (2016)

One perovskite oxide, ASnO3 (A = Sr, Ba), is a candidate for use as a transparent conductive oxide with high electron mobility in single crystalline form. However, the electron mobility of films grown on SrTiO3 substrates does not reach the bulk value, probably because of dislocation scattering that originates from the large lattice mismatch. This study investigates the effect of insertion of bilayer BaSnO3 / (Sr,Ba)SnO3 for buffering this large lattice mismatch between La:BaSnO3 and SrTiO3 substrate. The insertion of 200-nm-thick BaSnO3 on (Sr,Ba)SnO3 bilayer buffer structures reduces the number of dislocations and improves surface smoothness of the films after annealing as proved respectively by scanning transmission electron microscopy and atomic force microscopy. A systematic investigation of BaSnO3 buffer layer thickness dependence on Hall mobility of the electron transport in La:BaSnO3 shows that the highest obtained value of mobility is 78 cm2V−1s−1 because of its fewer dislocations. High electron mobility films based on perovskite BaSnO3 can provide a good platform for transparent-conducting-oxide electronic devices and for creation of fascinating perovskite heterostructures.
Role of MYC-Regulated Long Noncoding RNAs in Cell Cycle Regulation and Tumorigenesis (2015)

Our results provide novel regulatory mechanisms in MYC function through lncRNAs and new potential lncRNA targets of CRC.
Quantification of hydroperoxides by gas chromatography‐flame ionization detection and predicted response factors (2016)

Abstract The quantification of hydroperoxides is crucial in several areas, in particular in the fragrance domain, because they have been identified as skin sensitizers. The reference compounds necessary to calibrate the instruments have very limited availability, and require drastic storage conditions (‐78 °C) due to their instability. To overcome these limitations, we propose a GC‐FID approach involving their silylation, and the prediction of response factors. This procedure provides a good alternative to a full calibration down to a concentration level of 500 mg/kg, with an underestimation of about 20%. In the analysis of essential oils and fragrance concentrates, larger deviations are found; however, they are not inherent in the technique but rather in the chemistry of hydroperoxides that readily react with aldehydes to form peroxyhemiacetals, thereby decreasing the concentration of free hydroperoxides. These observations are in agreement with quantitative 1 H NMR and HPLC‐Chemiluminescence analyses. Copyright © 2016 John Wiley &amp; Sons, Ltd.
DNA amplification in tunicamycin-resistant Leishmania mexicana. Multicopies of a single 63-kilobase supercoiled molecule and their expression. (1988)

Tunicamycin-resistant variants of Leishmania mexicana were found to contain elevated activity of N-acetylglucosamine-1-phosphate transferase and amplified DNA (Kink, J. A., and Chang, K.-P. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 1253-1257). Complete digestion of their DNA with restriction endonucleases produced discrete ethidium bromide-staining bands after agarose gel electrophoresis. All four BamHI fragments of the amplified DNA were cloned separately into pBR322 and found to share no substantial sequence homology. DNA complementary to each of the cloned fragments is 64-128-fold more abundant in the variants than in the wild type cells. The amplified DNA appears to originate from a single chromosomal region of 63 kilobases. Individual copies of the 63 kilobases are each circularized at the newly formed junction site producing multiple extrachromosomal supercoiled molecules in the drug-resistant cells. There is overproduction of RNA ranging in size from 1.9 to 6.6 kilobases complementary to the amplified DNA in these cells.
Control for autonomous vehicles in collision avoidance maneuvers : LPV\n modeling and static feedback controller (2021)

This article presents a state feedback control design strategy for the\nstabilization of a vehicle along a reference collision avoidance maneuver. The\nstabilization of the vehicle is achieved through a combination of steering,\nacceleration and braking. A Linear Parameter-Varying (LPV) model is obtained\nfrom the linearization of a non-linear model along the reference trajectory. A\nrobust state feedback control law is computed for the LPV model. Finally,\nsimulation results illustrate the stabilization of the vehicle along the\nreference trajectory.\n
Long-term follow-up of suspected though unconfirmed MS (2008)

In potential MS patients seen in a tertiary referral center, the likelihood that a patient who is not diagnosed with MS will in the future develop a neurological disease is small. This study suggests that, in addition to playing a role in diagnosing MS, MRI can be helpful to exclude MS in clinically doubtful cases.
Commercial Manufacture of Halaven®: Chemoselective Transformations En Route to Structurally Complex Macrocyclic Ketones (2013)

Correction to: Commercial Manufacture of Halaven®: Chemoselective Transformations En Route to Structurally Complex Macrocyclic KetonesSynlett 2013; 24(03): 333-337DOI: 10.1055/s-0032-1318026
Interchangeable Stage and Probe Mechanisms for Microscale Universal Mechanical Tester (2011)

A microfabricated mechanical test platform has been designed, fabricated, and operated. This system consists of a reusable chip capable of large-displacement actuation, which interfaces to a test coupon chip compatible with synthesis conditions for many nanomaterials. Because only normal forces are used for mechanical interfacing, the two chips are not permanently connected, allowing exchange of the test coupon chips. The actuated test platform chip contains a thermal actuator driving a compliant displacement amplification transmission, and a bulk-micromachined well in which the test coupon chips may be placed and removed. The displacement amplification structure provides 40 of output displacement, extending a probe over the well and into contact with the test coupon. The test coupon contains compliant structures that are actuated by the probe from the test platform.
Wild and domestic animals variably display Neu5Ac and Neu5Gc sialic acids (2022)

Sialic acids are used as a receptor by several viruses and variations in the linkage type or C-5 modifications affect the binding properties. A species barrier for multiple viruses is present due to α2,3- or α2,6-linked sialic acids. The C-5 position of the sialic acid can be modified to form N-acetylneuraminic acid (Neu5Ac) or N-glycolylneuraminic acid (Neu5Gc), which acts as a determinant for host susceptibility for pathogens such as influenza A virus, rotavirus, and transmissible gastroenteritis coronavirus. Neu5Gc is present in most mammals such as pigs and horses but is absent in humans, ferrets, and dogs. However, little is known about C-5 content in wildlife species or how many C-5 modified sialic acids are present on N-linked glycans or glycolipids. Using our previously developed tissue microarray system, we investigated how 2 different lectins specific for Neu5Gc can result in varying detection levels of Neu5Gc glycans. We used these lectins to map Neu5Gc content in wild Suidae, Cervidae, tigers, and European hedgehogs. We show that Neu5Gc content is highly variable among different species. Furthermore, the removal of N-linked glycans reduces the binding of both Neu5Gc lectins while retention of glycolipids by omitting methanol treatment of tissues increases lectin binding. These findings highlight the importance of using multiple Neu5Gc lectins as the rich variety in which Neu5Gc is displayed can hardly be detected by a single lectin.
Integrin-Linked Kinase Regulates Bone Formation by Controlling Cytoskeletal Organization and Modulating BMP and Wnt Signaling in Osteoprogenitors (2017)

Cell-matrix interactions constitute a fundamental aspect of skeletal cell biology and play essential roles in bone homeostasis. These interactions are primarily mediated by transmembrane integrin receptors, which mediate cell adhesion and transduce signals from the extracellular matrix to intracellular responses via various downstream effectors, including integrin-linked kinase (ILK). ILK functions as adaptor protein at focal adhesion sites, linking integrins to the actin cytoskeleton, and has been reported to act as a kinase phosphorylating signaling molecules such as GSK-3β and Akt. Thereby, ILK plays important roles in cellular attachment, motility, proliferation and survival. To assess the in vivo role of ILK signaling in osteoprogenitors and the osteoblast lineage cells descending thereof, we generated conditional knockout mice using the Osx-Cre:GFP driver strain. Mice lacking functional ILK in osterix-expressing cells and their derivatives showed no apparent developmental or growth phenotype, but by 5 weeks of age they displayed a significantly reduced trabecular bone mass, which persisted into adulthood in male mice. Histomorphometry and serum analysis indicated no alterations in osteoclast formation and activity, but provided evidence that osteoblast function was impaired, resulting in reduced bone mineralization and increased accumulation of unmineralized osteoid. In vitro analyses further substantiated that absence of ILK in osteogenic cells was associated with compromised collagen matrix production and mineralization. Mechanistically, we found evidence for both impaired cytoskeletal functioning and reduced signal transduction in osteoblasts lacking ILK. Indeed, loss of ILK in primary osteogenic cells impaired F-actin organization, cellular adhesion, spreading, and migration, indicative of defective coupling of cell-matrix interactions to the cytoskeleton. In addition, BMP/Smad and Wnt/β-catenin signaling was reduced in the absence of ILK. Taken together, these data demonstrate the importance of integrin-mediated cell-matrix interactions and ILK signaling in osteoprogenitors in the control of osteoblast functioning during juvenile bone mass acquisition and adult bone remodeling and homeostasis. © 2017 American Society for Bone and Mineral Research.