gebhart/patrepeval huggingface dataset:
$W$-band Transmitter and Receiver for 10-Gb/s Impulse Radio With an Optical-Fiber Interface (2009)

A <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">W</i> -band millimeter-wave transmitter and receiver that are based on impulse radio (IR) architecture were developed. The IR-based apparatuses have an optical-fiber input/output interface board that supports multi protocol signals (OC-192 and 10 GbE) and that implements a forward error correction (FEC), enabling 10-Gb/s data transmission both in space and fiber seamlessly. Analyzing an IR-based receiver model with simple on/off demodulation architecture, required signal-to-noise ratios were calculated for IR-based systems affected by various inter-symbol interference (ISI) levels. A millimeter-wave module used in the transmitter, consisting of a 6.5-ps pulse modulator with InP-based HEMTs and a band-pass filter formed on an alumina substrate, emitted wavelets, or RF pulses, with an average power of -26 dBm, occupying frequencies between 78-93 GHz. A front-end module used in the receiver, consisting of two cascaded low-noise amplifiers, an envelope detector, and a limiting amplifier, had a sensitivity of -36 dBm. In a back-to-back test where the transmitter and receiver were connected by a waveguide, disabling the FEC, error-free operation was achieved with a test pattern of PRBS 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">31</sup> -1 at the OC-192 compliant data rate of 9.95328 Gb/s. Furthermore, using a horn antenna and enabling the FEC, radio transmission and reception in a distance of 20 cm were confirmed with a bit error rate of less than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> . These results confirmed the basic technologies for simple and compact IR-based systems, which could be used as an alternative to fiber optic cables.
Quality tracing in meat supply chains (2014)

The aim of this study was the development of a quality tracing model for vacuum-packed lamb that is applicable in different meat supply chains. Based on the development of relevant sensory parameters, the predictive model was developed by combining a linear primary model and the Arrhenius model as the secondary model. Then a process analysis was conducted to define general requirements for the implementation of the temperature-based model into a meat supply chain. The required hardware and software for continuous temperature monitoring were developed in order to use the model under practical conditions. Further on a decision support tool was elaborated in order to use the model as an effective tool in combination with the temperature monitoring equipment for the improvement of quality and storage management within the meat logistics network. Over the long term, this overall procedure will support the reduction of food waste and will improve the resources efficiency of food production.
Novel Reliability Methodology for Virtual Solutions (2019)

Reliability is crucial in the fiercely-competitive mobile network service provider environment. 5G application virtualization and cloud deployment introduce an entirely new dimension to the vendor requirements process. The ability to separate software from hardware, and select different vendors for each, creates the need to rationally allocate the quantifiable reliability requirements between these layers of separation in a multi-vendor virtualized environment. In this work, we define a comprehensive set of service-level reliability metrics, and develop a novel methodology to allocate these metrics to the service delivery platform layers using natural tunable parameters.
New ligands for complexation of lanthanoids: the synthesis and structures of a nonadentate Schiff-base ligand (L1) and of the complexes [ML1(OH2)](ClO4)3·3MeNO2(M = La, Pr) and [YL1](ClO4)3·3MeCN (1994)

The synthesis and structures of a nonadentate Schiff-base ligand L1, prepared from tris(2-aminoethyl)amine and 2,6-diformyl-4-methylphenol, and of its complexes with MIII ions (M = La, Pr and Y) are reported; [ML1(OH2)](ClO4)3·3MeNO2(M = La, Pr) are ten-coordinate species while [YL1](ClO4)3·3MeCN is nine-coordinate.
Bromodomain factor 1 corresponds to a missing piece of yeast TFIID (2000)

The basal transcription factor TFIID consists of the TATA-binding protein (TBP) and TBP-associated factors (TAFs). Yeast Taf67 is homologous to mammalian TAF(II)55. Using a yeast two-hybrid screen to identify proteins that interact with Taf67, we isolated Bromodomain factor 1 (Bdf1) and its homolog (Bdf2). The Bdf proteins are genetically redundant, as cells are inviable without at least one of the two BDF genes. Both proteins contain two bromodomains, a motif found in several proteins involved in transcription and chromatin modification. The BDF genes interact genetically with TAF67. Furthermore, Bdf1 associates with TFIID and is recruited to a TATA-containing promoter. Deletion of Bdf1 or the Taf67 Bdf-interacting domain leads to defects in gene expression. Interestingly, the higher eukaryotic TAF(II)250 has an acetyltransferase activity, two bromodomains, and an associated kinase activity. Its yeast homolog, Taf145, has acetyltransferase activity but lacks the bromodomains and kinase. Bdf1, like TAF(II)250, has a kinase activity that maps carboxy-terminal to the bromodomains. The structural and functional similarities suggest that Bdf1 corresponds to the carboxy-terminal region of higher eukaryotic TAF(II)250 and that the interaction between TFIID and Bdf1 is important for proper gene expression.
Lactobacillus gasseri APC 678 Reduces Shedding of the Pathogen Clostridium difficile in a Murine Model (2019)

<i>Clostridium difficile</i> is a common cause of health-care acquired diarrhea, resulting in a spectrum of disease from mild diarrhea to life-threatening illness. Sixty <i>Lactobacillus</i> strains were screened for anti-<i>C. difficile</i> activity using a co-culture method. Based on their ability to inhibit <i>C. difficile</i>, <i>L. gasseri</i> APC 678 and <i>L. rhamnosus</i> DPC 6111 were selected for study in a murine model of <i>C. difficile</i> infection. <i>L. gasseri</i> ATCC 33323, was included as a control. It was established that, relative to control mice not fed <i>Lactobacillus</i>, feeding with <i>L. gasseri</i> APC 678 resulted in a significant reduction by day 7 (8-fold, <i>p</i> = 0.017) of viable <i>C. difficile</i> VPI 10463 in the feces of mice. In contrast, neither <i>L. rhamnosus</i> DPC 6111 nor <i>L. gasseri</i> ATCC 33323 significantly reduced fecal <i>C. difficile</i> shedding. Sequencing of the cecal microbiota showed that in mice fed <i>L. gasseri</i> APC 678 there was a significant increase in bacterial diversity across a number of indices when compared to the control or other <i>Lactobacillus</i>-fed groups. There was no significant change in the relative abundance of Firmicutes or Bacteroidetes in the group fed <i>L. gasseri</i> APC 678 relative to the control, while the groups fed <i>L. rhamnosus</i> DPC 6111 or <i>L. gasseri</i> ATCC 33323 showed a significant decrease in the relative abundance of Firmicutes (<i>p</i> = 0.002 and <i>p</i> = 0.019, respectively) and a significant increase in Bacteroidetes (<i>p</i> = 0.002 and <i>p</i> = 0.023, respectively). These results highlight the potential of <i>L. gasseri</i> APC 678 as a live therapeutic agent to target <i>C. difficile</i> infection.
Hepatic expression of lipopolysaccharide-binding protein (Lbp) is induced by the gut microbiota through Myd88 and impairs glucose tolerance in mice independent of obesity (2020)

Our results demonstrate that the gut microbiota regulates hepatic expression of Lbp through MYD88-dependent signaling. LBP potentiates LPS inhibition of insulin signaling in vitro and impairs systemic glucose homeostasis in vivo.
Distributed massive MIMO: Algorithms, architectures and concept systems (2014)

Making MIMO truly “massive” involves liberating it from the shackles of form factor constraints, by allowing arbitrarily large groups of neighboring nodes to opportunistically form virtual antenna arrays for both transmission and reception. Moving such distributed MIMO (DMIMO) systems from the realm of information theory to practice requires synchronization of the cooperating nodes at multiple levels. We are interested in all-wireless systems which are severely constrained in the amount of information that can be exchanged among the cooperating nodes, in contrast to recent proposals in massive MIMO (co-located antennas) or base station cooperation (which relies on a high-speed wired backhaul). The goal of this paper is to point out some of the research issues unique to scaling up such DMIMO systems. We briefly review the significant technical progress in design and demonstration over the past few years, and describe a research agenda for the next few years based on fundamental questions in attaining the “distributed coherence” required to realize concept systems such as DMIMO communication at large carrier wavelengths (e.g., white space frequencies for which standard antenna arrays are too bulky) and distributed 911 for emergency and rescue scenarios.
Probing the active site tightness of DNA polymerase in subangstrom increments (2005)

We describe the use of a series of gradually expanded thymine nucleobase analogs in probing steric effects in DNA polymerase efficiency and fidelity. In these nonpolar compounds, the base size was increased incrementally over a 1.0-A range by use of variably sized atoms (H, F, Cl, Br, and I) to replace the oxygen molecules of thymine. Kinetics studies with DNA Pol I (Klenow fragment, exonuclease-deficient) in vitro showed that replication efficiency opposite adenine increased through the series, reaching a peak at the chlorinated compound. Efficiency then dropped markedly as a steric tightness limit was apparently reached. Importantly, fidelity also followed this trend, with the fidelity maximum at dichlorotoluene, the largest compound that fits without apparent repulsion. The fidelity at this point approached that of wild-type thymine. Surprisingly, the maximum fidelity and efficiency was found at a base pair size significantly larger than the natural size. Parallel bypass and mutagenesis experiments were then carried out in vivo with a bacterial assay for replication. The cellular results were virtually the same as those seen in solution. The results provide direct evidence for the importance of a tight steric fit on DNA replication fidelity. In addition, the results suggest that even high-fidelity replicative enzymes have more steric room than necessary, possibly to allow for an evolutionarily advantageous mutation rate.
Data from Molecular imaging of Bcr-Abl phosphokinase in a xenograft model (2023)

&lt;div&gt;Abstract&lt;p&gt;The purpose of this study was to determine whether the Bcr-Abl tyrosine kinase can be assessed by γ-imaging using an &lt;sup&gt;111&lt;/sup&gt;In-labeled anti-phosphotyrosine (APT) antibody, and if the response to treatment with imatinib could be detected using this imaging technique. APT antibody was labeled with &lt;sup&gt;111&lt;/sup&gt;In using ethylenedicysteine (EC) as a chelator. To determine if &lt;sup&gt;111&lt;/sup&gt;In-EC-APT could assess a nonreceptor tyrosine kinase, xenografts of the human chronic myelogenous leukemia cell line K562 were used. γ-Scintigraphy of the tumor-bearing mice, before and after imatinib treatment, was obtained 1, 24, and 48 h after they were given &lt;sup&gt;111&lt;/sup&gt;In-EC-APT (100 μCi/mouse i.v.). &lt;sup&gt;111&lt;/sup&gt;In-EC-APT is preferentially taken up by Bcr-Abl-bearing tumor cells when compared with &lt;sup&gt;111&lt;/sup&gt;In-EC-BSA or &lt;sup&gt;111&lt;/sup&gt;In-EC-IgG&lt;sub&gt;1&lt;/sub&gt; controls and comparable with the level of uptake of &lt;sup&gt;111&lt;/sup&gt;In-EC-Bcr-Abl. Imatinib treatment resulted in decreased expression of phospho-Bcr-Abl by Western blot analysis, which correlated with early (4 days after starting imatinib) kinase down-regulation as assessed by imaging using &lt;sup&gt;111&lt;/sup&gt;In-EC-APT. The optimal time to imaging was 24 and 48 h after injection of &lt;sup&gt;111&lt;/sup&gt;In-EC-APT. Although tumor regression was insignificant on day 4 after starting imatinib treatment, it was marked by day 14. &lt;sup&gt;111&lt;/sup&gt;In-EC-APT can assess intracellular phosphokinase activity, and down-regulation of phosphokinase activity predates tumor regression. This technique may therefore be useful in the clinic to detect the presence of phosphokinase activity and for early prediction of response. [Mol Cancer Ther 2009;8(3):703–10]&lt;/p&gt;&lt;/div&gt;
New Quinoline Linked Chalcone and Pyrazoline Conjugates: Molecular Properties Prediction, Antimicrobial and Antitubercular Activities (2017)

Abstract Two novel series comprising of forty two compounds have been synthesized by conjugating quinoline scaffold with chalcone as well as pyrazoline motifs. All the synthesized conjugates were tested for their antibacterial, antifungal and anti‐tubercular activities. Several of these novel compounds exhibited good to appreciable antibacterial activity against the tested bacterial strains. Compounds 4 j and 7 b were found to be the promising candidates exhibiting MIC 4 μg/mL against B. subtilis MTCC 121 and M. luteus MTCC 2470. Moreover, several conjugates significantly inhibited growth of certain fungal organisms. Furthermore, some of the conjugates displayed moderate anti‐tubercular activity against both H 37 R V as well as Rif R strains. The binding modes and effect of the C4 quinoline substitution on the activity have been studied using computational techniques. Methyl group enhances the antimicrobial activity upon replacement by aromatic phenyl group and this is supported by the experimental data.
System on a Package Innovations With Universal Chiplet Interconnect Express (UCIe) Interconnect (2023)

Universal Chiplet Interconnect Express (UCIe) is an open industry standard interconnect for developing an open chiplet ecosystem, where chiplets from any supplier can be packaged anywhere in an interoperable manner. This article delves into the architectural and protocol aspects that we developed and have been adopted in the UCIe 1.0 specification. We present our results on these aspects based on our implementation studies.
Process-based karst modelling to relate hydrodynamic and hydrochemical characteristics to system properties (2013)

Abstract. More than 30% of Europe's land surface is made up of karst exposures. In some countries, water from karst aquifers constitutes almost half of the drinking water supply. Hydrological simulation models can predict the large-scale impact of future environmental change on hydrological variables. However, the information needed to obtain model parameters is not available everywhere and regionalisation methods have to be applied. The responsive behaviour of hydrological systems can be quantified by individual metrics, so-called system signatures. This study explores their value for distinguishing the dominant processes and properties of five different karst systems in Europe and the Middle East with the overall aim of regionalising system signatures and model parameters to ungauged karst areas. By defining ten system signatures derived from hydrodynamic and hydrochemical observations, a process-based karst model is applied to the five karst systems. In a stepwise model evaluation strategy, optimum parameters and their sensitivity are identified using automatic calibration and global variance-based sensitivity analysis. System signatures and sensitive parameters serve as proxies for dominant processes and optimised parameters are used to determine system properties. To test the transferability of the signatures, they are compared with the optimised model parameters and simple climatic and topographic descriptors of the five karst systems. By sensitivity analysis, the set of system signatures was able to distinguish the karst systems from one another by providing separate information about dominant soil, epikarst, and fast and slow groundwater flow processes. Comparing sensitive parameters to the system signatures revealed that annual discharge can serve as a proxy for the recharge area, that the slopes of the high flow parts of the flow duration curves correlate with the fast flow storage constant, and that the dampening of the isotopic signal of the rain as well as the medium flow parts of the flow duration curves have a non-linear relation to the distribution of groundwater dynamics. Even though, only weak correlations between system signatures and climatic and topographic factors could be found, our approach enabled us to identify dominant processes of the different systems and to provide directions for future large-scale simulation of karst areas to predict the impact of future change on karst water resources.
Method for Phase Noise Impact Compensation in 60 GHz OFDM Receivers (2020)

This paper presents a method for phase noise impact compensation in 60 GHz OFDM receivers and provides the results of performance evaluation using OFDM PHY parameters defined in the IEEE 802.11ay standard. It is shown that the phase noise in 60 GHz band has a critical impact on the OFDM performance for high data rate transmission employing high order modulation constellations. The proposed compensation method combines time domain algorithm predicting the linear average phase trend on the OFDM symbol duration and estimation in frequency domain of phase noise spectrum realization and convolution with correction filter response. Both algorithms use Maximum A Posteriori Probability (MAP) estimation approach to find the optimal solution and are applied successively. The proposed algorithms have moderate implementation complexity which is especially important for high speed 11ay hardware modem architecture. The performance of the proposed algorithms is evaluated in the frequency flat and frequency selective channels with phase noise model adopted in the IEEE 802.11ay.
Synthesis and Surface Energy Measurement of Semi-Fluorinated, Low-Energy Surfaces (1998)

The surface energy and stability of pendent semifluorinated groups (SFG) attached to the surface of PDMS were measured using the JKR technique. SFG, made up of a flexible hydrocarbon segment and a mesogen, i.e., the fluorocarbon segment, combine the low surface energy aspect of a (−CF2−) and (−CF3) surface with a resistance to surface reconstruction. An acid chloride group present on the end of the hydrocarbon segment allowed the SFG to be covalently attached to the surface of hydrolyzed elastomeric PDMS model networks. Whereas the hydrolyzed PDMS surfaces had surface energies of 1−10 J/m2 and showed large adhesion hysteresis, the SFG-treated surfaces displayed a minimum adhesion hysteresis and had a surface energy of ∼ 14.5 mJ/m2. This result suggests that in the SFG-modified surfaces both (−CF2−) and (−CF3) groups cover the surface. As the extent of hydrolysis of the PDMS networks increased, the density of attached SFG increased (as shown by XPS results), but the surface energy remained constant. No effect of length of time the networks were kept in contact or the rate of unloading was observed.
ChemInform Abstract: Rhodium‐Catalyzed C—C Bond Cleavage: Construction of Acyclic Methyl Substituted Quaternary Stereogenic Centers. (2010)

Abstract The present new rhodium‐catalyzed enantioselective conversion of various cyclobutanols provides access to methyl substituted quaternary stereogenic centers in high yields and enantioselectivities.
Tackling Alzheimer’s Disease pathology by modulating the binding of Tau to synaptic vesicles (2018)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
SupplementaryFigure 1 from Androgen Receptor Upregulation Mediates Radioresistance after Ionizing Radiation (2023)

&lt;p&gt;Supplementary Figure 1. In vitro experiments demonstrating increase AR protein level post-radiotherapy; A) Nuclear AR staining, B) 18F-FDHT uptake. C) Isodose distribution of multibeam animal EBRT.&lt;/p&gt;
ChemInform Abstract: P2Et Phosphazene: A Mild, Functional Group Tolerant Base for Soluble, Room Temperature Pd‐Catalyzed C—N, C—O, and C—C Cross‐Coupling Reactions. (2015)

Abstract The organic superbase P2‐Et is shown to possess distinct reactivity across a diverse set of cross‐coupling reactions at room temperature.
T-Mobile QoE lab (2013)

T-Mobile USA is looking at all possible ways to optimize the quality of user experience (QoE) for our customers in while balanceing with our network resources and device energy consumptions needs. In the mobile smart phone world, users often have a the misperception that people often held about use experience is the faster the network speed is and, the faster the phone CPU speed is;, the better the quality of experience (QoE) will beis. On the contrary, we intend to use three practical examples to unveil the mystery behind the mobile network black box and illustrate it is actually the end-to-tend (E2E) latency which impacts the QoE of one of the most commonly used data services -- mobile browsing. A lengthy E2E latency due to rarely-understood and hard-to-uncovered phone or network issues may render a very poor browsing page loading speed time even if you have a super hero dual core smart phone with the fastest 4G network speed. In order to understand the E2E latency better in the transient wireless channel conditions and optimize data QoE in a much fastermore expedient way, we advocate the use of the cCross-device/network evaluation methodology. Finally, we presented a few research questions that we are facing and to solicit the research community's input.
Label-Free Quantitation (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Energy transfer between colloidal semiconductor nanocrystals in an optical microcavity (2006)

The authors have studied nonradiative energy transfer between semiconductor nanocrystals (NCs) placed in a Fabry-Pérot microcavity. The spectrally integrated fluorescence from a monolayer of single sized NCs in the cavity is enhanced by a factor of 4.8 compared to free space. For a monolayer of mixed sized NCs, the acceptor NC fluorescence intensity is enhanced by an additional factor of 2.7 due to energy transfer processes. When the cavity mode is resonant with the acceptor NC fluorescence emission maximum, donor NC emission is completely suppressed, providing a narrow spectral output.