gebhart/patrepeval huggingface dataset:
1372 XmAb143, an engineered IL18 heterodimeric Fc-fusion, features improved stability, reduced potency, and insensitivity to IL18BP (2022)

<h3>Background</h3> Interleukin-18 (IL18) is a proinflammatory cytokine that modulates both innate and adaptive immune responses. Mature IL18 promotes the expansion, survival, and cytotoxicity of T and NK cells expressing the heterodimeric IL18 receptor. Preclinical studies with recombinant IL18 have demonstrated anti-tumor activity in animal models, including impressive synergy with both immune checkpoint inhibitors and CAR-T therapy. However, clinical development as a single agent exhibited poor pharmacokinetics and an overall lack of efficacy despite heavy dosing. IL18 participates in a negative feedback loop with IL18 binding protein (IL18BP), a very high affinity natural inhibitor induced by IFNγ. As IL18BP upregulation was observed in early phase clinical trials, it likely limited the efficacy of recombinant IL18. <h3>Methods</h3> Prior work at Xencor demonstrated that reduced-potency IL15/IL15Rα-Fc fusion proteins exhibited superior pharmacokinetics, pharmacodynamics, and safety in non-human primates through reduction of receptor-mediated clearance. Following that principle, we generated monovalent IL18-Fc fusions upon our XmAb® heterodimeric Fc platform and introduced substitutions that could modulate IL18 stability, affinity toward the IL18 heterodimeric receptor, and affinity toward IL18BP. <h3>Results</h3> To address IL18’s poor native stability, we engineered a disulfide bridge into the cytokine’s structure which increased the thermal denaturation temperature from 45 °C to 65 °C. This had beneficial effects on the cytokine’s yield and solution behavior, and translated into a significant improvement of PK in mice. Variants at IL18 positions along the IL18 receptor and IL18BP interfaces were explored in vitro by measuring PD-L1 induction on KG-1 cells, with and without a high concentration of IL18BP. Recombining hits generated a potency series with variants exhibiting over a 2,000-fold reduction in PD-L1 induction potency as compared to WT IL18-Fc. Importantly, we identified variants that no longer detectably bound IL18BP, relieving natural inhibition of our engineered IL18-Fc. In vivo immune-mediated inflammation by our lead IL18-Fc, XmAb143, was explored in human PBMC engrafted mouse models of graft versus host disease (GvHD). We observed dose-dependent exacerbation of GvHD, with corresponding dramatic increases in the numbers, activation, and IFNy release of T and NK cells as compared to a human PBMC only control. Conversely, XmAb143 pharmacodynamics in cynomolgus monkey pilot tox studies was observed only at higher doses, and serum half-life improved from hours to days over WT IL18-Fc. <h3>Conclusions</h3> XmAb143, our engineered monovalent IL18-Fc fusion demonstrates insensitivity to IL18BP inhibition, robust inflammation activity in vivo, and improved pharmacokinetics in mice and cynomolgus monkeys.
Electromagnetically Coupled Inverted-FL Antenna with Self-Complementary Structure for Mobile Phone (2009)

In this paper, the authors describe the inverted-FL antenna design. This unique design is realized by integrating the electromagnetically coupled inverted-F antenna with a self-complementary structure with an inverted-L element. The proposed antenna realizes a broadband characteristic without matching load and impedance transformer to match 50 ohms using electromagnetically coupled feeding structure. This antenna acquired the broadband and multi-band characteristics covering the GSM850/GSM900/DCS/PCS/UMTS2100/UMTS2600 bands and the 2.5G/3.5G bands for Mobile WiMAX by simulation and measurement.
Protection and Long-Lived Immunity Induced by the ID93/GLA-SE Vaccine Candidate against a Clinical Mycobacterium tuberculosis Isolate (2015)

Mycobacterium tuberculosis HN878 represents a virulent clinical strain from the W-Beijing family, which has been tested in small animal models in order to study its virulence and its induction of host immune responses following infection. This isolate causes death and extensive lung pathology in infected C57BL/6 mice, whereas lab-adapted strains, such as M. tuberculosis H37Rv, do not. The use of this clinically relevant isolate of M. tuberculosis increases the possibilities of assessing the long-lived efficacy of tuberculosis vaccines in a relatively inexpensive small animal model. This model will also allow for the use of knockout mouse strains to critically examine key immunological factors responsible for long-lived, vaccine-induced immunity in addition to vaccine-mediated prevention of pulmonary immunopathology. In this study, we show that the ID93/glucopyranosyl lipid adjuvant (GLA)-stable emulsion (SE) tuberculosis vaccine candidate, currently in human clinical trials, is able to elicit protection against M. tuberculosis HN878 by reducing the bacterial burden in the lung and spleen and by preventing the extensive lung pathology induced by this pathogen in C57BL/6 mice.
Ist der normotherme kardiopulmonale Bypass mit einer erhohten Morbiditat verbunden? [Is normothermic cardiopulmonary bypass associated with increased morbidity?] (1993)

There is some evidence of improved myocardial protection with warm continuous blood cardioplegia. Warm cardioplegia however implies warm (normothermic) cardiopulmonary bypass (CPB). We evaluated retrospectively the influence of bypass temperature on the intra- and postoperative course of 121 patients, operated on for valvular and/or coronary artery disease. Only elective procedures with continuous blood cardioplegia were included. The patients were divided in two groups: warm group (n = 78): normothermic CPB (venous temperature &gt; 33 degrees C) cold group (n = 43): hypothermic CPB (&lt; 33 degrees C). Results: normothermic CPB resulted in a significantly shorter CPB time (84 + 3 min vs. 98 +/- 6 min, p = 0.02, mean +/- 1 standard error of the mean). In addition there was a higher need for vasoconstrictive drugs during cold CPB (Noradrenalin: 19 +/- 3 micrograms vs. 90 +/- 32 micrograms, p = 0.003). There was no difference in enzyme levels on the first postoperative day (amylase, creatinkinase, creatinin), in postoperative complication rate (resuscitations, rethoracotomies, cerebrovascular incidents) and mortality (warm 3% vs. cold 2%) between the two groups. The postoperative time until extubation however was significantly shorter in the warm group (33 +/- 5 h vs. 60 +/- 11 h, p = 0.04). Conclusion: there is no evidence of increased morbidity due to normothermic CPB. The shorter time until extubation may be due to a improved postoperative lung function and/or a more stable hemodynamic postoperative course after normothermic CPB.
Early Neurological ASsessment with pupillometrY during Cardiac Arrest REsuscitation (EASY-CARE): protocol for an observational multicentre prospective study (2022)

NCT05192772.
Structured online interactions: improving the decision-making of small discussion groups (2000)

A quantitative research experiment was used to examine whether a group's computer-mediated decision-making could be improved by providing a scripted structure to the groups text chat discussion. The study compared a regular chat discussion to a scripted chat discussion using Lead Line, a program that allows people to add a layer of pre-authored structure to regular text chat. We found that groups were more likely to come to consensus in structured chat discussions. In addition, groups applied the structure they learned to subsequent regular chat sessions.
Inducing and Probing Localized Excitons in Atomically Thin Semiconductors via Tip‐Enhanced Cavity‐Spectroscopy (2021)

Abstract In atomically thin semiconductors, localized exciton (X L ) coupled to light provides a new class of optical sources for potential applications in quantum communication. However, in most studies, X L photoluminescence (PL) from crystal defects has mainly been observed in cryogenic conditions because of their sub‐wavelength emission region and low quantum yield at room temperature. Hybrid‐modality of cavity‐spectroscopy to induce and probe the X L emissions at the nanoscale in atomically thin semiconductors is presented. By placing a WSe 2 monolayer on the two extremely sharp Au tips in a bowtie antenna with a radius of curvature of &lt;1 nm, tensile strain of ≈0.3% is effectively induced in a &lt;30 nm region to create robust X L states. The Au tip then approaches the strained crystal region to enhance the X L emissions and probe them with tip‐enhanced photoluminescence (TEPL) spectroscopy at room temperature. Through this triple‐sharp‐tips cavity‐spectroscopy with &lt;15 nm spatial resolution, TEPL enhancement as high as ≈4.0 × 10 4 by the Purcell effect is achieved, and peak energy shifts of X L up to ≈40 meV are observed. This approach combining nano‐cavity and ‐spectroscopy provides a systematic way to induce and probe the radiative emission of localized excitons in 2D semiconductors offering new strategies for dynamic quantum nano‐optical devices.
Kinetic energy and rainfall intensity relationships: A review (2019)

Although it is widely recognized how the knowledge of the kinetic energy (KE) of precipitation plays a fundamental role in soil erosion studies, its direct evaluation is not widespread. As a matter of facts, direct measurements of the kinetic energy of precipitation require the use of sophisticated and expensive tools. Commonly, the following approach is used to deal with this issue, that is the indirect estimation of the kinetic energy from other most widespread measured hydrological variables (i.e rainfall intensity, I). Precipitation intensity measurements are widely available for many countries throughout world, on the other hand the challenge is therefore represented by establishing the best expression to relate the kinetic energy to the rainfall intensity. The aim of the study is to define among the KE-I expressions proposed in literature which best fits KE values calculated from potential erosive events collected by a disdrometer installed in Rome (Italy).
Software for real-time control of a tidal liquid ventilator. (1999)

The purpose of this project was to develop and test computer software and control algorithms designed to operate a tidal liquid ventilator. The tests were executed on a 90-MHz Pentium PC with 16 MB RAM and a prototype liquid ventilator. The software was designed using Microsoft Visual C++ (Ver. 5.0) and the Microsoft Foundation Classes. It uses a graphic user interface, is multithreaded, runs in real time, and has a built-in simulator that facilitates user education in liquid-ventilation principles. The operator can use the software to specify ventilation parameters such as the frequency of ventilation, the tidal volume, and the inspiratory-expiratory time ratio. Commands are implemented via control of the pump speed and by setting the position of two two-way solenoid-controlled valves. Data for use in monitoring and control are gathered by analog-to-digital conversion. Control strategies are implemented to maintain lung volumes and airway pressures within desired ranges, according to limits set by the operator. Also, the software allows the operator to define the shape of the flow pulse during inspiration and expiration, and to optimize perfluorochemical liquid transfer while minimizing airway pressures and maintaining the desired tidal volume. The operator can stop flow during inspiration and expiration to measure alveolar pressures. At the end of expiration, the software stores all user commands and 30 ventilation parameters into an Excel spreadsheet for later review and analysis. Use of these software and control algorithms affords user-friendly operation of a tidal liquid ventilator while providing precise control of ventilation parameters.
Lifetime of delocalized positronium inα−SiO2 (1999)

The lifetime of delocalized triplet-state positronium in $\ensuremath{\alpha}\ensuremath{-}{\mathrm{SiO}}_{2}$ is settled to be $\ensuremath{\sim}270\mathrm{ps}$ by analyzing the magnetic field dependence of the intensities of the narrow positronium peaks in the angular correlation of positron annihilation radiation spectra. The lifetime component of $\ensuremath{\sim}500\mathrm{ps},$ which is attributed to the positronium in previous reports, is not due to the delocalized positronium. A recently proposed interpretation of this component based on the assumption of the ortho-para conversion of the positronium is also dismissed.
Expression of CD14, IL10, and Tolerogenic Signature in Dendritic Cells Inversely Correlate with Clinical and Immunologic Response to TARP Vaccination in Prostate Cancer Patients (2017)

<b>Purpose:</b> Despite the vast number of clinical trials conducted so far, dendritic cell (DC)-based cancer vaccines have mostly shown unsatisfactory results. Factors and manufacturing procedures essential for these therapeutics to induce effective antitumor immune responses have yet to be fully characterized. We here aimed to identify DC markers correlating with clinical and immunologic response in a prostate carcinoma vaccination regimen.<b>Experimental Design:</b> We performed an extensive characterization of DCs used to vaccinate 18 patients with prostate carcinoma enrolled in a pilot trial of T-cell receptor gamma alternate reading frame protein (TARP) peptide vaccination (NCT00908258). Peptide-pulsed DC preparations (114) manufactured were analyzed by gene expression profiling, cell surface marker expression and cytokine release secretion, and correlated with clinical and immunologic responses.<b>Results:</b> DCs showing lower expression of tolerogenic gene signature induced strong antigen-specific immune response and slowing in PSA velocity, a surrogate for clinical response. These DCs were also characterized by lower surface expression of CD14, secretion of IL10 and MCP-1, and greater secretion of MDC. When combined, these four factors were able to remarkably discriminate DCs that were sufficiently potent to induce strong immunologic response.<b>Conclusions:</b> DC factors essential for the activation of immune responses associated with TARP vaccination in prostate cancer patients were identified. This study highlights the importance of in-depth characterization of DC vaccines and other cellular therapies, to understand the critical factors that hinder potency and potential efficacy in patients. <i>Clin Cancer Res; 23(13); 3352-64. ©2017 AACR</i>.
Pressurized fluidized-bed hydroretorting of Eastern oil shales. Progress report, July--September 1988 (1988)

The Devonian oil shales of the Eastern United States are a significant domestic energy resource. The overall objective of the 3-year program, is to perform the research necessary to develop the pressurized fluidized-bed hydroretorting (PFH) process for producing oil from Eastern oil shales. The program also incorporates research on technologies in areas such as raw shale preparation, beneficiation, product separation, and waste disposal that have the potential of improving the economics and/or environmental acceptability of recovering oil from oil shales using the PFH process. The program is divided into the following eight tasks: Task 1, PFH Scoping Studies; Task 2, PFH Optimization Tests; Task 3, Testing of Process Improvement Concepts; Task 4, Beneficiation Research; Task 5, Operation of PFH on Beneficiated Shale; Task 6, Environmental Data and Mitigation Analyses; Task 7, Sample Procurement, Preparation, and Characterization; Task 8, Project Management and Reporting. In order to accomplish all the program objectives, the Institute of Gas Technology, the prime contractor, is working with six other institutions; the University of Alabama/Mineral Resources Institute, Illinois Institute of Technology, the University of Michigan, Ohio State University, Tennessee Technological University and the University of Pittsburgh. This report presents the work performed during the fourth program quarter from July 1 through September 30, 1988.
Mutation of the PDGFRB gene as a cause of idiopathic basal ganglia calcification (2012)

Mutations of PDGFRB further support the involvement of this biological pathway in IBGC pathophysiology.
ChemInform Abstract: Harpuloside, a Triterpenoid Saponin from Harpullia ramiflora. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Cavity Filling Analysis and Design (2016)

No AccessInjection Mold Design EngineeringApr 2016Cavity Filling Analysis and DesignDavid O. KazmerDavid O. Kazmerhttps://doi.org/10.3139/9781569905715.005SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2016Pages: 109-140Print ISBN: 978-1-56990-570-8eISBN: 978-1-56990-571-5 Copyright & Permissions© 2016 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Biological characterization of sulfoxaflor, a novel insecticide (2010)

The novel chemistry of sulfoxaflor, its unique biological spectrum of activity and its lack of cross-resistance highlight the potential of sulfoxaflor as an important new tool for the control of sap-feeding insect pests.
FRAMEWORK FOR PROBABILISTIC ANALYSIS OF RECURRENT LANDSLIDES: A CASE STUDY OF EL BERRINCHE (2008)

It is well known that β-(1→3)-Glucans present high applicative potential in human health as immunostimulating agents. Numerous studies have highlighted this, but mainly used native polysaccharides extracted from various natural sources. These compounds are therefore inevitably polydisperse but also present structures that are not homogeneous, in an analytical point of view. This is the reason why we have achieved the chemical synthesis of small glucan-mannitol derivatives especially found in brown seaweeds. The targets differ from each other by the nature of the conjunction between the laminaribiose and the mannose or mannitol, i.e., (1→6) or (1→3). We established that (I) these molecules were efficiently obtained from glucose, laminaribiose and/or mannose derivatives; (II) the synthetic plan has to be adapted to the first connection between a glucosyl entity and the mannosyl residue; and (III) resulting pure compounds may be used as the standard for analytical purposes.
Maximum likelihood modeling of orbits of nonlinear ODEs (2004)

This report treats a new approach to the problem of periodic signal estimation. The idea is to model the periodic signal as a function of the state of a second order nonlinear ordinary differential equation (ODE). This is motivated by Poincare theory which is useful for proving the existence of periodic orbits for second order ODEs. The functions of the right hand side of the nonlinear ODE are then parameterized, and a maximum likelihood algorithm is developed for estimation of the parameters of these unknown functions from the measured periodic signal. The approach is analyzed by derivation and solution of a system of ODEs that describes the evolution of the Cramer-Rao bound over time. The proposed methodology reduces the number of estimated unknowns at least in cases where the actual signal generation resembles that of the imposed model. This in turn is expected to result in an improved accuracy of the estimated parameters.
Performance evaluation of an optical hybrid switching system (2004)

We propose a new optical hybrid switching system that takes advantage of both optical burst switching (OBS) and optical circuit switching (OCS) technologies. This system classifies incoming IP traffic flows into short-lived and long-lived flows. We model the system as a single server queue in a Markovian environment. The burst generation process is assumed to follow a two-state Markov modulated Poisson process (MMPP), and the service rate fluctuates based on the number of concurrent OCS sessions. Results for the mean delay and queue size are derived.
CLASSIFYING INFRASTRUCTURE USING THERMAL IR SIGNATURES (2006)

The purpose of this study was to determine whether Thermal/IR spectral data could be used to distinguish between pavements and rooftops in the urban environment. The surface temperatures of pavements and rooftops were modeled as a function of time and environmental conditions using 1-D heat transfer theory. The model was implemented in MATLAB® using a finite difference approach that accounted for various soil depths, pavement materials and thicknesses, roof insulations, and roof types. Simulations were run with weather data from the typical meteorological year (TMY) data sets derived from the 1961-1990 National Solar Radiation Data Base (NSRDB). Theoretical thermal signatures for rooftops and pavements were developed for various days of the TMY. Thermal/IR data acquired with the 15-channel (0.45μm - 12.2μm) Advanced Thermal and Land Applications Sensor (ATLAS) for the Atlanta area were used to verify the model. The simulated thermal signatures were compared with actual ATLAS data for May 1997 and showed very good agreement. Several analyses were carried out to determine both visually and statistically if the spectral information could distinguish between rooftops and pavements. Test locations were ground-proofed in order to validate results of different analysis techniques. Additionally, a Normalized Thermal Index (NTI) analysis was performed using the ATLAS Thermal/IR bands. Bands 13 (9.6 – 10.2 μm) and 14 (10.2 – 11.2 μm) provided the best clarity for pavements and bands 10 (8.2 – 8.6 μm) and 15 (11.2 – 12.2 μm) were best for rooftops.
A large fraction of trisomy 12, 17p − , and 11q − CLL cases carry unidentified microdeletions of miR-15a/16-1 (2022)

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia and is characterized by chromosomal aberrations including 13q, 11q, and 17p deletions and a trisomy of chromosome 12 (T12). 13q deletions are often associated with 11q and 17p deletions in aggressive cases. Conversely, T12 CLLs show a variable prognosis, and association with 13q deletions is uncommon. The <i>miR-15a/16-1</i> cluster is the functional target of 13q deletions, leading to <i>BCL2</i> overexpression. Chromosomal aberrations in CLL are associated with prognosis, and their identification is carried out by fluorescence in situ hybridization (FISH). Since standard FISH only detects large deletions, we investigated the presence of undetected microdeletions targeting <i>miR-15a/16-1</i> in CLL cases. We found that ∼34% of CLL samples show an unreported loss of the <i>miR-15a/16-1</i> locus regardless of their cytogenetic profile. Interestingly, 15 out of 39 (∼39%) of all CLLs with T12, carry microdeletions of <i>miR-15a/16-1</i>, indicating that, in patients with T12, <i>miR-15a/16-1</i> are mostly inactivated by microdeletions. In addition, ∼40% of CLL cases bearing T12, 17p<sup>-</sup>, and 11q<sup>-</sup> showed unidentified microdeletions of <i>miR-15a/16-1</i>, suggesting that <i>miR-15a/16-1</i> loss cooperates with such chromosomal alterations in CLL. These data may have clinical relevance for the successful stratification of patients for treatment.