gebhart/patrepeval huggingface dataset:
The iterative two-stage population approach to IVGTT minimal modeling: improved precision with reduced sampling (2001)

The minimal model method is widely used to estimate glucose effectiveness (S(G)) and insulin sensitivity (S(I)) from intravenous glucose tolerance test (IVGTT) data. In the standard protocol (sIVGTT, 0.33 g/kg glucose bolus given at time 0), which allows the simultaneous assessment of beta-cell function, the precision of the individualized estimates often degrades and particularly so in the presence of reduced sampling schedules. Here, we investigated the use of a population approach, the iterative two-stage (ITS) approach, to analyze 16 sIVGTTs in healthy subjects and to obtain refined estimates of S(G) and S(I) in the population and in the individual subjects. The ITS is based on calculation of the population mean and standard deviation of the parameters at each iteration and then use of them as prior information for the individual analyses. Theoretically, the use of a prior in the ITS should improve the precision of the individual estimates. The customary approach (standard two stage, STS), where modeling is performed separately for each individual subject, does not take the population knowledge into account. We used both frequent (FSS, 30 samples) and (quasi-optimally) reduced (RSS, 14 samples) sampling schedules. For the FSS, STS gave estimates (mean +/- SD) for S(G) = 2.66 +/- 1.09 x 10(-2). min(-1) and S(I) = 6.46 +/- 6.99 10(-4). min(-1). microU(-1). ml, with an average precision of 51 (range 5-176) and 33% (3-91), respectively. RSS radically worsened the precision of both S(G) and S(I). However, RSS and ITS gave S(G) = 2.59 +/- 0.73 and S(I) = 6.06 +/- 7.28, with an average precision of 23 (12-42) and 27% (), respectively. In conclusion, population minimal modeling of sIVGTT data improves the precision of individual estimates of glucose effectiveness and insulin sensitivity, as the theory predicts, and, even with reduced sampling, the improvement is substantial.
microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer (2014)

miR-139-5p plays a pivotal role in colon cancer through inhibiting cell proliferation, metastasis, and promoting apoptosis and cell cycle arrest by targeting oncogenic NOTCH1.
Long-term outcomes for neoadjuvant versus adjuvant chemotherapy in early breast cancer: meta-analysis of individual patient data from ten randomised trials (2017)

Cancer Research UK, British Heart Foundation, UK Medical Research Council, and UK Department of Health.
20‐4: High‐efficiency Perovskite QLED Achieving BT.2020 Green Chromaticity (2017)

A green perovskite‐quantum‐dot (Per‐QD) light‐emitting diode with high efficiency and color purity was fabricated. This device exhibited a narrow spectrum with a half width of 19 nm and covered the BT.2020 color gamut. Improving an electron‐transport layer increased the external quantum efficiency to 6.2%.
Directly coupled chromatography-atomic spectroscopy. Part 1. Directly coupled gas chromatography-atomic spectroscopy. A review (1986)

L. Ebdon, S. Hill and R. W. Ward, Analyst, 1986, 111, 1113 DOI: 10.1039/AN9861101113
MEET: A Monte Carlo Exploration-Exploitation Trade-off for Buffer Sampling (2022)

Data selection is essential for any data-based optimization technique, such as Reinforcement Learning. State-of-the-art sampling strategies for the experience replay buffer improve the performance of the Reinforcement Learning agent. However, they do not incorporate uncertainty in the Q-Value estimation. Consequently, they cannot adapt the sampling strategies, including exploration and exploitation of transitions, to the complexity of the task. To address this, this paper proposes a new sampling strategy that leverages the exploration-exploitation trade-off. This is enabled by the uncertainty estimation of the Q-Value function, which guides the sampling to explore more significant transitions and, thus, learn a more efficient policy. Experiments on classical control environments demonstrate stable results across various environments. They show that the proposed method outperforms state-of-the-art sampling strategies for dense rewards w.r.t. convergence and peak performance by 26% on average.
Modified Uridines with C5-methylene Substituents at the First Position of the tRNA Anticodon Stabilize U·G Wobble Pairing during Decoding (2008)

Post-transcriptional modifications at the first (wobble) position of the tRNA anticodon participate in precise decoding of the genetic code. To decode codons that end in a purine (R) (i.e. NNR), tRNAs frequently utilize 5-methyluridine derivatives (xm(5)U) at the wobble position. However, the functional properties of the C5-substituents of xm(5)U in codon recognition remain elusive. We previously found that mitochondrial tRNAs(Leu(UUR)) with pathogenic point mutations isolated from MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) patients lacked the 5-taurinomethyluridine (taum(5)U) modification and caused a decoding defect. Here, we constructed Escherichia coli tRNAs(Leu(UUR)) with or without xm(5)U modifications at the wobble position and measured their decoding activities in an in vitro translation as well as by A-site tRNA binding. In addition, the decoding properties of tRNA(Arg) lacking mnm(5)U modification in a knock-out strain of the modifying enzyme (DeltamnmE) were examined by pulse labeling using reporter constructs with consecutive AGR codons. Our results demonstrate that the xm(5)U modification plays a critical role in decoding NNG codons by stabilizing U.G pairing at the wobble position. Crystal structures of an anticodon stem-loop containing taum(5)U interacting with a UUA or UUG codon at the ribosomal A-site revealed that the taum(5)U.G base pair does not have classical U.G wobble geometry. These structures provide help to explain how the taum(5)U modification enables efficient decoding of UUG codons.
Further Reading (2018)

No AccessInjection Molding Processing DataNov 2018Further ReadingAlberto Naranjo C., Maria del Maria del, Juan Diego Sierra M., Juan Rodrigo Sanz, Tim A. OsswaldAlberto Naranjo C., Maria del Maria del, Juan Diego Sierra M., Juan Rodrigo Sanz, Tim A. Osswaldhttps://doi.org/10.3139/9781569906675.008SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapter FiguresReferencesRelatedDetails 2018Pages: 123-123Print ISBN: 978-1-56990-666-8eISBN: 978-1-56990-667-5 Copyright & Permissions© 2019 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
The tale of two MS MARCO -- and their unfair comparisons (2023)

The MS MARCO-passage dataset has been the main large-scale dataset open to the IR community and it has fostered successfully the development of novel neural retrieval models over the years. But, it turns out that two different corpora of MS MARCO are used in the literature, the official one and a second one where passages were augmented with titles, mostly due to the introduction of the Tevatron code base. However, the addition of titles actually leaks relevance information, while breaking the original guidelines of the MS MARCO-passage dataset. In this work, we investigate the differences between the two corpora and demonstrate empirically that they make a significant difference when evaluating a new method. In other words, we show that if a paper does not properly report which version is used, reproducing fairly its results is basically impossible. Furthermore, given the current status of reviewing, where monitoring state-of-the-art results is of great importance, having two different versions of a dataset is a large problem. This is why this paper aims to report the importance of this issue so that researchers can be made aware of this problem and appropriately report their results.
Period-doubling route to chaos in the chlorite-thiocyanate chemical oscillator (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPeriod-doubling route to chaos in the chlorite-thiocyanate chemical oscillatorChristopher J. Doona and Sory I. DoumbouyaCite this: J. Phys. Chem. 1994, 98, 2, 513–517Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/j100053a027https://doi.org/10.1021/j100053a027research-articleACS PublicationsRequest reuse permissionsArticle Views82Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
66‐1: Invited Paper: Liquid‐Crystal Mixture with a Composition Including Highly Reliable Fluorinated Diluter and RM Monomer for PSVA and PI‐less IPS LCDs (2020)

We developed a high reliable diluter 3HFFH3 for LC compositions and a reactive mesogen (RM)‐monomer carrying a polarized UV absorption unit, chalcone. As the diluter does not carry a vinyl group, a trade‐off between response property and reliability could be solved, and we succeeded to fabricate the PSVA cell that showed fast response speed and high voltage holding ratio. In addition, we also succeeded to fabricate the PI‐less IPS cell owing to use the RM‐monomer carrying the chalcone unit combined with the diluter 3HFFH3.
A Design Concept of an Intelligent Onboard Computer Network (2023)

The article suggests design principles of an advanced onboard computer network with an intelligent control system. It describes the main advantages of designing an onboard computer network based on fibre optics, which allows the implementation of an integrated intellectual system performing intelligent inference in emergency situations. The suggested principles significantly increase the reliability and fault tolerance of avionics suits, which, in turn, enhances flight safety. The suggested concept aims to solve a number of important problems including the design of a switchless computing environment, the development of the methods for dynamic reconfiguration of avionics suits with such an environment, and the implementation of a specialised multilevel intelligent avionics system within this environment.
Mutations inC8ORF37cause Bardet Biedl syndrome (BBS21) (2016)

Bardet Biedl syndrome (BBS) is a multisystem genetically heterogeneous ciliopathy that most commonly leads to obesity, photoreceptor degeneration, digit anomalies, genito-urinary abnormalities, as well as cognitive impairment with autism, among other features. Sequencing of a DNA sample from a 17-year-old female affected with BBS did not identify any mutation in the known BBS genes. Whole-genome sequencing identified a novel loss-of-function disease-causing homozygous mutation (K102*) in C8ORF37, a gene coding for a cilia protein. The proband was overweight (body mass index 29.1) with a slowly progressive rod-cone dystrophy, a mild learning difficulty, high myopia, three limb post-axial polydactyly, horseshoe kidney, abnormally positioned uterus and elevated liver enzymes. Mutations in C8ORF37 were previously associated with severe autosomal recessive retinal dystrophies (retinitis pigmentosa RP64 and cone-rod dystrophy CORD16) but not BBS. To elucidate the functional role of C8ORF37 in a vertebrate system, we performed gene knockdown in Danio rerio and assessed the cardinal features of BBS and visual function. Knockdown of c8orf37 resulted in impaired visual behavior and BBS-related phenotypes, specifically, defects in the formation of Kupffer's vesicle and delays in retrograde transport. Specificity of these phenotypes to BBS knockdown was shown with rescue experiments. Over-expression of human missense mutations in zebrafish also resulted in impaired visual behavior and BBS-related phenotypes. This is the first functional validation and association of C8ORF37 mutations with the BBS phenotype, which identifies BBS21. The zebrafish studies hereby show that C8ORF37 variants underlie clinically diagnosed BBS-related phenotypes as well as isolated retinal degeneration.
Computation of flow in a blood vessel with prescribed movement in a Cartesian coordinate system (2002)

The Japan Sooiety of Meohanioal Engineers 2314 直交座標系 に お け る振動壁 を有す る血管内の 流れ の 数値計算 Computa． tioIl of flow in a blood vesse ］with prescribed movenlellt in a Cartesian coordinate system
Improved glucose metabolism and decreased weight gain in leptin-resistant, IGFBP2-deficient, db/db mice induced by AZP-3404, a 9-amino acid analog of IGFBP2 (2021)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Synthesis and structural and optical properties of ZnO micro- and nanostructures grown by the vapour–liquid–solid method (2006)

ZnO micro- and nanostructures have been grown by the catalytic vapour–liquid–solid method on silicon and silicon carbide. These micro- and nanostructures were characterized by scanning electron microscope, x-ray diffraction and photoluminescence measurements. The characterization shows that the ZnO nano- and microrods grown have diameters of around 200 nm on the Si substrates and 600 nm when using the SiC substrates. The length ranges from 0.5 to 10 μm.
Reaction of nitrogen oxide (N2O5) with water on carbonaceous surfaces (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of nitrogen oxide (N2O5) with water on carbonaceous surfacesL. Brouwer, M. J. Rossi, and D. M. GoldenCite this: J. Phys. Chem. 1986, 90, 19, 4599–4603Publication Date (Print):September 1, 1986Publication History Published online1 May 2002Published inissue 1 September 1986https://doi.org/10.1021/j100410a025RIGHTS & PERMISSIONSArticle Views136Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (662 KB) Get e-Alerts
HRM in the Public Sector: Is It Enough? (2009)

This major Handbook provides a state-of-the-art study of the recent history and future development of international public management reform.
Specificity Determining Residues in Ammonia- and Glutamine-dependent Carbamoyl Phosphate Synthetases (2002)

Carbamoyl phosphate synthetases (CPSs) utilize either glutamine or ammonia for the ATP-dependent generation of carbamoyl phosphate. In glutamine-utilizing CPSs (e.g. the single Escherichia coli CPS and mammalian CPS II), the hydrolysis of glutamine to yield ammonia is catalyzed at a triad-type glutamine amidotransferase domain. Non-glutamine-utilizing CPSs (e.g. rat and human CPS I), lacking the catalytic cysteine residue, can generate carbamoyl phosphate only in the presence of free ammonia. Frog CPS I (fCPS I), unlike mammalian CPS Is, retains most of the glutamine amidotransferase residues conserved in glutamine-utilizing CPSs, including an intact catalytic triad, and could therefore be expected to use glutamine. Our work with native fCPS I provides the first demonstration of the inability of this enzyme to bind/utilize glutamine. To determine why fCPS I is unable to utilize glutamine, we compared sequences of glutamine-using and non-glutamine-using CPSs to identify residues that are present or conservatively substituted in all glutamine-utilizing CPSs but absent in fCPS I. We constructed the site-directed mutants Q273E, L270K, Q273E/N240S, and Q273E/L270K in E. coli CPS and have determined that simultaneous occurrence of the two substitutions, Gln-->Glu and Leu-->Lys, found in the frog CPS I glutamine amidotransferase domain are sufficient to eliminate glutamine utilization by the E. coli enzyme.
Pancreatic Intraepithelial Neoplasia (2004)

Great efforts have been devoted to detecting preinvasive precursors to ductal carcinoma of the pancreas in the hope of improving the currently bleak prognosis of invasive pancreatic cancer. Intensive investigations of the pancreas have led to the recognition of intraductal papillary mucinous neoplasms (IPMNs) and the detection of preinvasive precursors to conventional ductal carcinoma. The pancreatic intraepithelial neoplasia (PanIN) nomenclature for precursor lesions of ductal carcinoma was developed at the "Pancreatic Cancer Think Tank" held in the United States in 1999. However, some reports of precursor lesions have suggested that these definitions do not encompass the full spectrum of precursors of ductal carcinoma, and these issues were the subject of the "Forum on Carcinoma In Situ of the Pancreas" held in Japan in 2002. After this forum, it became clear that the existing definitions of PanINs needed to be revised and expanded. Both participants of the Pancreatic Cancer Think Tank and the Forum gathered together at a meeting on precursor lesions of pancreatic cancer in 2003, and an international consensus on the diagnostic criteria for PanINs and IPMNs was created. We describe herein the current understanding of precursor lesions of pancreatic cancer.
A 28nm HKMG super low power embedded NVM technology based on ferroelectric FETs (2016)

We successfully implemented a one-transistor (1T) ferroelectric field effect transistor (FeFET) eNVM into a 28nm gate-first super low power (28SLP) CMOS technology platform using two additional structural masks. The electrical baseline properties remain the same for the FeFET integration and the JTAG-controlled 64 kbit memory shows clearly separated states. High temperature retention up to 250 °C is demonstrated and endurance up to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> cycles was achieved. The FeFET unique properties make it the best candidate for eNVM solutions in sub-2x technologies for low-cost IoT applications.
Toward New Biomaterials (2000)

Polymers are widely used for a large range of medical devices used as biomaterials on a temporary, intermittent, and long-term basis. It is now well accepted that the initial rapid adsorption of proteins to polymeric surfaces affects the performance of these biomaterials. However, protein adsorption to a polymer surface can be modulated by an appropriate design of the interface. Extensive study has shown that these interactions can be minimized by coating with a highly hydrated layer (hydrogel), by grafting on the surface different biomolecules, or by creating domains with chemical functions (charges, hydrophilic groups). Our laboratory has investigated the latter approach over the past 2 decades, in particular the synthesis and the biological activities of polymers to improve the biocompatibility of blood-contacting devices. These soluble and insoluble polymers were obtained by chemical substitution of macromolecular chains with suitable groups able to develop specific interactions with biological components. Applied to compatibility with the blood and the immune systems, this concept has been extended to interactions of polymeric biomaterials with eukaryotic and prokaryotic cells. The design of new biomaterials with low bacterial attachment is thus under intensive study. After a brief overview of current trends in the surface modifications of biocompatible materials, we will describe how biospecific polymers can be obtained and review our recent results on the inhibition of bacterial adhesion using one type of functionalized polymer obtained by random substitution. This strategy, applied to existing or new materials, seems promising for the limitation of biomaterial-associated infections.
Interfacial Defect of Lithium Metal in Solid‐State Batteries (2021)

Abstract All‐solid‐state battery with Li metal anode is a promising rechargeable battery technology with high energy density and improved safety. Currently, the application of Li metal anode is plagued by the failure at the interfaces between lithium metal and solid electrolyte (SE). However, little is known about the defects at Li–SE interfaces and their effects on Li cycling, impeding further improvement of Li metal anodes. Herein, by performing large‐scale atomistic modeling of Li metal interfaces with common SEs, we discover that lithium metal forms an interfacial defect layer of nanometer‐thin disordered lithium at the Li–SE interfaces. This interfacial defect Li layer is highly detrimental, leading to interfacial failure such as pore formation and contact loss during Li stripping. By systematically studying and comparing incoherent, coherent, and semi‐coherent Li–SE interfaces, we find that the interface with good lattice coherence has reduced Li defects at the interface and has suppressed interfacial failure during Li cycling. Our finding discovered the critical roles of atomistic lithium defects at interfaces for the interfacial failure of Li metal anode, and motivates future atomistic‐level interfacial engineering for Li metal anode in solid‐state batteries.
Apparent Monomer (2017)

IUPAC recommendations on source-based nomenclature for single-strand polymers have so far addressed its application mainly to copolymers, non-linear polymers and polymer assemblies, and within generic source-based nomenclature of polymers. In this document, rules are formulated for devising a satisfactory source-based name for a polymer, whether homopolymer or copolymer, which are as clear and rigorous as possible. Thus, the source-based system for naming polymers is presented in a totality that serves as a user-friendly alternative to the structure-based system of polymer nomenclature. In addition, because of their widespread and established use, recommendations for the use of traditional names of polymers are also elaborated.
Assessment of aflatoxin exposure, growth faltering and the gut microbiome among children in rural Guatemala: protocol for an observational prospective cohort and bioreactor simulations (2023)

Ethics approval was obtained from Arizona State University Institutional Review Board (IRB; STUDY00016799) and Wuqu' Kawoq/Maya Health Alliance IRB (WK-2022-003). Findings will be disseminated in scientific presentations and peer-reviewed publications.
Effectiveness of BNT162b2 and mRNA-1273 Second Doses and Boosters for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and SARS-CoV-2–Related Hospitalizations: A Statewide Report From the Minnesota Electronic Health Record Consortium (2022)

Using vaccine data combined with electronic health records, we report that mRNA boosters provide greater protection than a 2-dose regimen against SARS-CoV-2 infection and related hospitalizations. The benefit of a booster was more evident in the elderly and those with comorbidities.