gebhart/patrepeval huggingface dataset:
The fgl2 prothrombinase/fibroleukin gene is required for lipopolysaccharide-triggered abortions and for normal mouse reproduction (2004)

Increased fgl2 prothrombinase activity in maternal decidua and fetal trophoblasts may trigger abortions by proinflammatory cytokines induced by bacterial lipopolysaccharide (LPS) in mice and is implicated in human recurrent miscarriages and pre-eclampsia. Defining the physiological and pathological role of the fgl2/fibroleukin gene required an fgl2-knockout mouse and data on normal pattern of fgl2 expression during pregnancy. Expression of fgl2 protein was determined by immunostaining with specific antibody. Fgl2 knockout mice were generated and typed by PCR for presence of the altered gene. Immunostaining of timed CBAxDBA/2 mouse matings in a low-abortion-rate colony showed a distinct pattern of development of fgl2 protein expression in maternal decidua, and in embryonic tissues in early pregnancy. Outbred (mixed background) heterozygous fgl2 +/-x+/- matings with a similar low abortion rate showed selective occult loss of both +/- and, to a greater extent, -/- embryos prior to gestation day 11.5, in association with haemorrhage at the anti-mesometrial pole of fgl2-deficient embryo. LPS injected on day 6.5 caused classical abortions at mid-pregnancy in fgl2 +/+x+/+ matings, but not -/-x-/- matings. Physiological expression of fgl2 in fetal trophoblast may prevent occult loss in early pregnancy, along with other coagulation factors, but fgl2 expression is required for LPS to induce abortion pathology.
THE CLINICAL APPLICATION OF CRRT—CURRENT STATUS: Modalities of Continuous Renal Replacement Therapy: Technical and Clinical Considerations (2009)

Continuous renal replacement therapies (CRRT) are continuous forms of renal functional replacement used to manage acute kidney injury (AKI) in the critically ill patient. Depurative mechanisms include convection, diffusion, and membrane adsorption utilizing high-flux highly permeable biocompatible dialysis membranes. The simultaneous infusion of replacement fluid permits fluid removal without intravascular volume contraction and better hemodynamic stability, metabolic control to almost normal parameters, and removal of large-size toxins and cytokines. Moreover, CRRT allows better long-term clearance of small and middle molecules than other dialysis modalities. This article focuses on the different modalities of CRRT and reviews both the basic concepts and the newest approaches to the management of the critically ill patient with AKI.
Enhanced Low-Temperature Performance of Li–CF[sub x] Batteries (2007)

This work describes the continued examination of the low-temperature performance of the Li–CFx electrochemical couple in a −40°C or colder environment. Previously, the efficacy of subfluorinated CFx (SFCFx) cathode active materials was demonstrated; preliminary results indicated that the material was functional at rates up to C/10 at −40°C. However, there were often substantial voltage fluctuations during discharge, accompanied with inconsistent capacity yields and sometimes dramatic polarization events. In the research described herein, an investigation of various electrolyte and cathode compositions was conducted in an effort to optimize performance. In particular, several different electrolyte solvent formulations were examined using a salt content of either 1 or 0.5 M LiBF4. A further modification consisted of addition of an anion receptor to the electrolyte that was intended to be a LiF-solvating agent. The most promising electrolyte was tested with several different SFCFx compositions created using either graphitic or multiwall nanotube precursor materials. Electrochemical evaluation showed that the best SFCFx-based test cells were able to deliver specific capacity values up to five times greater than control cells (containing conventional CF1.08 powder) at −40°C under discharge currents as high as C/5 with composite electrodes thicker than 100 µm.
Photoacoustic imaging of ultrasound-induced displacements in ocular tissues. (2011)

Acoustic radiation force produces compression that can be used for assessment of tissue stiffness, generally by detection of displacements in the phase-resolved pulse/echo ultrasound waveform. In this report, we describe use of photoacoustics for tracking displacements produced by acoustic radiation force in the iris and retina. The probe consisted of a 20 MHz transducer with a central aperture through which 532 nm laser pulses were introduced. Laser pulses were emitted simultaneously with excitation of the transducer by a 20 MHz monocycle. For a 12 ms period, we interleaved tonebursts (generating force) between successive laser pulses/monocycles. Iris displacements averaged 26.5 and 76.7 μm photoacoustically versus 24.9 and 71.3 μm by pulse/echo at 60 and 100 W cm-2 force, respectively. For the retina, the displacements were 14.6 and 25.3 μm photoacoustically versus 12.4 and 25.8 by pulse/echo. Pulse/echo displacements were more difficult to discern due to their broadness and anatomic non-specificity. The photoacoustic signal is advantageous because of its broadband character and because the photoacoustic signal is only generated by specific molecules, which in the retina would correspond to melanin in the pigment epithelium. As little is known about retinal elasticity, this technique offers an avenue toward investigation of this tissue property.
Wide Flare-angle horn antenna with enhanced directivity using a third-order bandpass frequency selective surface (2013)

International audience
Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia (2016)

Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) suppress normal hematopoietic activity in part by enabling a pathogenic inflammatory milieu in the bone marrow. In this report, we show that elevation of angiopoietin-1 in myelodysplastic CD34(+) stem-like cells is associated with higher risk disease and reduced overall survival in MDS and AML patients. Increased angiopoietin-1 expression was associated with a transcriptomic signature similar to known MDS/AML stem-like cell profiles. In seeking a small-molecule inhibitor of this pathway, we discovered and validated pexmetinib (ARRY-614), an inhibitor of the angiopoietin-1 receptor Tie-2, which was also found to inhibit the proinflammatory kinase p38 MAPK (which is overactivated in MDS). Pexmetinib inhibited leukemic proliferation, prevented activation of downstream effector kinases, and abrogated the effects of TNFα on healthy hematopoietic stem cells. Notably, treatment of primary MDS specimens with this compound stimulated hematopoiesis. Our results provide preclinical proof of concept for pexmetinib as a Tie-2/p38 MAPK dual inhibitor applicable to the treatment of MDS/AML. Cancer Res; 76(16); 4841-9. ©2016 AACR.
Supplementary Figure 3 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase (2023)

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A Phase I trial of MGD006 in patients with relapsed acute myeloid leukemia (AML) (2014)

Meeting abstracts AML is characterized by excessive proliferation and infiltration of neoplastic cells of hematopoietic origin. AML occurs at a median age of 67 and will lead to an estimated 10,460 deaths in the United States in 2014. Therapy for AML has changed little in the last 30 years, and
Methods, systems and apparatus for controlling third harmonic voltage when operating a multi-space machine in an overmodulation region (2023)

Methods, system and apparatus are provided for controlling third harmonic voltages when operating a multi-phase machine in an overmodulation region. The multi-phase machine can be, for example, a five-phase machine in a vector controlled motor drive system that includes a five-phase PWM controlled inverter module that drives the five-phase machine. Techniques for overmodulating a reference voltage vector are provided. For example, when the reference voltage vector is determined to be within the overmodulation region, an angle of the reference voltage vector can be modified to generate a reference voltage overmodulation control angle, and a magnitude of the reference voltage vector can be modified, based on the reference voltage overmodulation control angle, to generate a modified magnitude of the reference voltage vector. By modifying the reference voltage vector, voltage command signals that control a five-phase inverter module can be optimized to increase output voltages generated by the five-phase inverter module.
Holistic 3D Scene Understanding from a Single Image with Implicit Representation (2021)

We present a new pipeline for holistic 3D scene understanding from a single image, which could predict object shapes, object poses, and scene layout. As it is a highly ill-posed problem, existing methods usually suffer from inaccurate estimation of both shapes and layout especially for the cluttered scene due to the heavy occlusion between objects. We propose to utilize the latest deep implicit representation to solve this challenge. We not only propose an image-based local structured implicit network to improve the object shape estimation, but also refine the 3D object pose and scene layout via a novel implicit scene graph neural network that exploits the implicit local object features. A novel physical violation loss is also proposed to avoid incorrect context between objects. Extensive experiments demonstrate that our method outperforms the state-of-the-art methods in terms of object shape, scene layout estimation, and 3D object detection.
Thermal Performance of Violet and Blue Single-Quantum-Well Nonpolarm-Plane InGaN Light-Emitting Diodes (2013)

We compare thermal performance of violet and blue single-quantum-well nonpolar m-plane InGaN/GaN light-emitting diodes (LEDs) over a temperature range from 25 to 140 °C. The hot/cold factor, defined as the ratio between the output power at high and low temperatures, improved as the quantum-well thickness increased from 3 to 10 nm. A hot/cold factor of 93% was measured under high injection current for the 10-nm-thick blue-emitting quantum well LED, indicating high thermal stability. The increase in hot/cold factor with current density for blue samples indicates possible contributions of Shockley–Read–Hall recombination for quantum wells of increased indium composition.
Intracellular degradation of somatostatin‐14 following somatostatin‐receptor 3‐mediated endocytosis in rat insulinoma cells (2008)

Somatostatin receptor (SSTR) endocytosis influences cellular responsiveness to agonist stimulation and somatostatin receptor scintigraphy, a common diagnostic imaging technique. Recently, we have shown that SSTR1 is differentially regulated in the endocytic and recycling pathway of pancreatic cells after agonist stimulation. Additionally, SSTR1 accumulates and releases internalized somatostatin‐14 (SST‐14) as an intact and biologically active ligand. We also demonstrated that SSTR2A was sequestered into early endosomes, whereas internalized SST‐14 was degraded by endosomal peptidases and not routed into lysosomal degradation. Here, we examined the fate of peptide agonists in rat insulinoma cells expressing SSTR3 by biochemical methods and confocal laser scanning microscopy. We found that [ 125 I]Tyr11‐SST‐14 rapidly accumulated in intracellular vesicles, where it was degraded in an ammonium chloride‐sensitive manner. In contrast, [ 125 I]Tyr1‐octreotide accumulated and was released as an intact peptide. Rhodamine‐B‐labeled SST‐14, however, was rapidly internalized into endosome‐like vesicles, and fluorescence signals colocalized with the lysosomal marker protein cathepsin D. Our data show that SST‐14 was cointernalized with SSTR3, was uncoupled from the receptor, and was sorted into an endocytic degradation pathway, whereas octreotide was recycled as an intact peptide. Chronic stimulation of SSTR3 also induced time‐dependent downregulation of the receptor. Thus, the intracellular processing of internalized SST‐14 and the regulation of SSTR3 markedly differ from the events mediated by the other SSTR subtypes.
CPR for SSDs (2019)

Modern storage systems are built upon the assumption that the capacity of a storage device does not change. This capacity-invariant interface forces a flash-based storage device to trade performance for reliability when, in fact, it can maintain both if a graceful reduction in capacity were to be allowed. We argue that relaxing the fixed capacity abstraction of the storage device allows for a better capacity-performance-reliability (CPR) tradeoff. We then outline existing device-internal mechanisms for building a capacity-variant flash device, and describe the necessary changes in the storage stack.
Ramipril-Induced Generalized Pustular Psoriasis: Case Report and Literature Review (2010)

Mrs. M.S. is a 67-year-old African American woman with a history of rheumatoid arthritis and psoriatic arthritis who presented to the emergency room with complaint of new-onset rash, chills, and fatigue after she started taking ramipril (5 mg orally every day) for her hypertension. The rash involved entire upper chest, both arms, palms, and soles and was characterized as exfoliating with scattered small pustules of 1-2 mm in size. Patient was admitted with a differential diagnosis of exfoliative dermatitis versus adverse drug reaction for which her ramipril was stopped. After admission, the patient spiked a temperature of 102 degrees F with chills, the entire workup for which was negative, including blood cultures, chest x-ray, and urine analysis. She underwent skin biopsy to find the cause of her rash. With her given clinical characteristics, she was presumed to have generalized pustular psoriasis (GPP), which was later confirmed by biopsy results. She was treated with methylprednisolone to which she responded dramatically with much improvement in her rash and her fever subsided. The flare of GPP was considered to be secondary to ramipril. After reviewing the published literature, there are no published cases of ramipril-induced GPP. Captopril, a different angiotensin converting enzyme (ACE) inhibitor, is known to cause flare of GPP. We presented this case as apart from being the first reported case of ramipril-induced GPP; clinicians and dermatologist should also be aware of this potentially serious complication of psoriasis when they start ramipril in patients with psoriasis.
Polarization-independent tunable wavelength-selective filter using a liquid crystal (1991)

The authors demonstrate a polarization-independent liquid crystal Fabry-Perot interferometer. An input light beam was split into two orthogonal polarized beams by a polarization beam splitter and prism and the polarization of one beam was rotated 90 degrees by a half-wave plate. These two beams were filtered through different points of the filter and recombined. Two transmission peaks corresponding to these beams usually appeared. However, there were some regions where the two beams were superimposed. At these regions, the filter had a tuning range of over 50 nm with a band pass of 0.4-0.5 nm and a low fiber-to-fiber loss of 3 dB. At the regions where two peaks appeared, the two peaks could be superimposed by applying different voltages.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Prospect for development of a pulsed CPT Raman Ramsey clock using atomic vapor (2010)

The phenomenon of all-optical Ramsey interference using pulsed coherent population trapping (CPT) beams provides a new avenue for developing frequency standards using atomic vapor. In this study, we show that frequency narrowed Ramsey fringes can be produced in rubidium vapor without the effect of power broadening. We observed fringes of width as narrow as 1 kHz using a buffer-gas filled rubidium cell. A compact injection-locked laser (ILL) system was used to generate CPT beams. Studies also show that ac Stark effect on Ramsey fringes can be reduced, and higher frequency stability can be achieved in a clock application. The results are encouraging to propose an architecture for development of a pulsed CPT Ramsey clock. In this paper, we also provide related discussions on clock frequency stability, and our plans for future experiments.
Assessing epithelial cell nuclear morphology by using azimuthal light scattering spectroscopy (2006)

We describe azimuthal light scattering spectroscopy (phi/LSS), a novel technique for assessing epithelial-cell nuclear morphology. The difference between the spectra measured at azimuthal angles phi = 0 degrees and phi = 90 degrees preferentially isolates the single backscattering contribution due to large (approximately 10 microm) structures such as epithelial cell nuclei by discriminating against scattering from smaller organelles and diffusive background. We demonstrate the feasibility of using phi/LSS for cancer detection by showing that spectra from cancerous colon tissue exhibit significantly greater azimuthal asymmetry than spectra from normal colonic tissues.
Electrochemiluminescence from porous silicon in formic acid liquid-junction cells (1995)

Visible light emission from porous silicon can be stimulated by applying a positive bias to a formic acid/sodium formate liquid junction cell. The emission lasts for 45 min at +2.75 V applied potential (&amp;lt;5 mA/cm2, power conversion efficiency ≳10−2%) and is reliably generated from n- or p-type porous silicon. An applied voltage as low as 1.3 V is capable of generating the red (720 nm) emission, indicating that current-induced chemical reactions aid in the generation of charge carriers. A mechanism involving oxidation of formic acid followed by electron injection from a CO2− radical is proposed. Infrared spectra of the porous silicon surface taken after anodization show formation of a stable silyl-ester species that is thought to be responsible for the increase in radiative recombination efficiency through passivation of surface defects.
Adaptive robust control of MIMO nonlinear systems with guaranteed transient performance (2002)

This paper deals with adaptive robust control of a class of multi-input multi-output (MIMO) nonlinear systems, with parametric uncertainties, unknown nonlinear functions, modelling error and external disturbances. The idea of adaptive robust control Lyapunov functions (ARCLF) is introduced to formulate a general framework of the adaptive robust control. Specific ARCLFs are sought out for different applications, including MIMO nonlinear systems with arbitrary known relative degrees transformable to a semi-strict feedback form, in which unknown parameters are also allowed to enter control channels. The method bridges the gap between adaptive control and deterministic robust control by preserving their advantages, i.e. the asymptotic stability of adaptive control in the presence of parametric uncertainties and guaranteed transient performance with prescribed precision of deterministic robust control in the presence of both parametric uncertainties and unknown nonlinear functions and, at the same time, eliminating drawbacks of each. Simulation results verify the effectiveness of the suggested method.
Relating SERS Intensity to Specific Plasmon Modes on Sphere Segment Void Surfaces (2009)

Colloidal-crystal templated electrodeposition can be used to fabricate sphere segment void (SSV) substrates that show large, reproducible enhancements in surface-enhanced Raman spectroscopy (SERS). These SSV substrates support a variety of plasmon modes and can be fully characterized by white light dispersion measurements allowing the direct identification of the modes predicted by computational models of the nanoscale optical fields. Comparing plasmon absorption with SERS enhancements as a function of sphere segment void diameter and metal thickness for a series of SSV substrates allows the identification of the specific plasmon modes, which give rise to large SERS enhancements at different laser wavelengths and in different media. The measured SERS intensities show direct correlation to the plasmonic modes of the structures providing a guide to the design of efficient surfaces for SERS.
Pressure Transient Tests and Flow Regimes in Fractured Reservoirs (2013)

Abstract Fractures are common features in many well-known reservoirs. Naturally fractured reservoirs consist of fractures in igneous, metamorphic, and sedimentary rocks (matrix). Faults in many naturally fractured carbonate reservoirs often have high-permeability zones and are connected to numerous fractures that have varying conductivities. Furthermore, in many naturally fractured reservoirs, faults and fractures can be discrete (rather than connected network dual-porosity systems). In this paper we investigate the pressure transient behavior of continuously and discretely naturally fractured reservoirs using semi-analytical solutions. These fractured reservoirs can contain periodically or arbitrarily distributed finite- and/or infinite-conductivity fractures with different lengths and orientations. In some of our earlier papers, we showed that in terms of pressure transient, neither continuously nor discretely fractured reservoirs behave like the Warren and Root (1963) dual-porosity model. Unlike the single-derivative shape of the Warren and Root model, derivatives of pressure transient tests in fractured reservoirs exhibit more than 10 flow regimes. There are seven important factors that dominate the pressure transient test-flow regime behavior of fractured and faulted reservoirs; i.e., fractures and/or faults that: 1) intersect the wellbore parallel to its axis, with a dipping angle of 90° (vertical fractures), including hydraulic fractures; 2) intersect the wellbore with dipping angles from 0° to less than 90°; 3) are in the vicinity of the wellbore; 4) have extremely high- or low-fracture and fault conductivities; 5) have various sizes and distributions; 6) have high- and low-matrix block permeabilities; and 7) have damaged fractures (skin zone) due to drilling and completion operations and fluids. All flow regimes associated with these factors are shown for a number of continuously and discretely fractured reservoirs with different well and fracture configurations. For a few cases, these flow regimes are compared with those from the field data. History matchings of the pressure transient data generated by using our discretely and continuously fractured reservoir model with the Warren and Root (1963) type dual-porosity models are also presented.
A quantitative competitive reverse transcription-polymerase chain reaction technique to measure porcine interferon-gamma. (1998)

In swine, as in other mammals, interferon-gamma (IFN-gamma) plays an important role in the regulation of the immune response. The objective of this work was to develop a sensitive, quantitative competitive reverse transcription-polymerase chain reaction (qcRT-PCR) assay, using an internal cRNA standard, to monitor the expression of porcine IFN-gamma gene. We applied this qcRT-PCR assay to quantify the expression of IFN-gamma transcripts in peripheral blood mononuclear cells (PBMC) incubated for different times with or without concanavalin A (ConA). Results showed that the expression of the IFN-gamma transcripts in PBMC occurred within the first 2 h after mitogenic stimulation and reached a peak after 24 h of incubation with ConA. The qcRT-PCR technique provides an efficient and sensitive tool for studying the expression of porcine IFN-gamma gene under a variety of experimental conditions. This will help to understand the regulation of T cell-mediated immune responses by IFN-gamma at the gene level.