gebhart/patrepeval huggingface dataset:
(S)-4-Methyl-2-(methylamino)pentanoic Acid [4,4-Bis(4-fluorophenyl)butyl]amide Hydrochloride, a Novel Calcium Channel Antagonist, Is Efficacious in Several Animal Models of Pain (2000)

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXT(S)-4-Methyl-2-(methylamino)pentanoic Acid [4,4-Bis(4-fluorophenyl)butyl]amide Hydrochloride, a Novel Calcium Channel Antagonist, Is Efficacious in Several Animal Models of PainYuntao Song, S. Scott Bowersox, David T. Connor, David J. Dooley, Susan M. Lotarski, Thomas Malone, George Miljanich, Elizabeth Millerman, Michael F. Rafferty, David Rock, Bruce D. Roth, Joann Schmidt, Sally Stoehr, Balazs G. Szoke, Charles Taylor, Mark Vartanian, and Yong-Xiang WangView Author Information Pfizer Global Research and Development, Ann Arbor Laboratories, Pfizer Inc., 2800 Plymouth Road, Ann Arbor, Michigan 48105, and Elan Pharmaceuticals, Inc., 3760 Haven Avenue, Menlo Park, California 94025 Cite this: J. Med. Chem. 2000, 43, 19, 3474–3477Publication Date (Web):September 1, 2000Publication History Received21 March 2000Published online1 September 2000Published inissue 1 September 2000https://pubs.acs.org/doi/10.1021/jm000134nhttps://doi.org/10.1021/jm000134nrapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views317Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Antagonists,Assays,Calcium,Neurophysiology,Rodent models Get e-Alerts
Performance of absolute and recursive feedback methods with HSUPA closed loop transmit diversity (2012)

3GPP is investigating uplink transmit diversity alternatives for High Speed Uplink Packet Access. This paper presents a closed loop beamforming transmit diversity scheme where NodeB determines the transmit antenna weight vectors and feedback is used for signaling the optimal weights to the user equipment. Two promising feedback method candidates are presented and benchmarked in various conditions on system level against the baseline performance without transmit diversity. In each time slot the absolute feedback method signals the whole weight vector information, while the recursive feedback method signals only a single bit and the weight vector is recursively calculated from multiple bits sent over consecutive time slots. The results show that both feedback methods are capable of providing gain over the baseline in simulated conditions. However, while the recursive feedback method requires less signaling bits per slot, it is more vulnerable to the effects of weight signaling errors due to the signaling error propagation.
American sign language recognition with the kinect (2011)

We investigate the potential of the Kinect depth-mapping camera for sign language recognition and verification for educational games for deaf children. We compare a prototype Kinect-based system to our current CopyCat system which uses colored gloves and embedded accelerometers to track children's hand movements. If successful, a Kinect-based approach could improve interactivity, user comfort, system robustness, system sustainability, cost, and ease of deployment. We collected a total of 1000 American Sign Language (ASL) phrases across both systems. On adult data, the Kinect system resulted in 51.5% and 76.12% sentence verification rates when the users were seated and standing respectively. These rates are comparable to the 74.82% verification rate when using the current(seated) CopyCat system. While the Kinect computer vision system requires more tuning for seated use, the results suggest that the Kinect may be a viable option for sign verification.
Detection of generalized tonic-clonic seizures from ear-EEG based on EMG analysis (2018)

Ear-EEG contains enough GTCS-specific EMG activity for GTCS detection to be feasible. Ear-EEG could be considered for nocturnal GTCS monitoring as a supplement to SUDEP preventive interventions.
Piezoelectric Actuator Design and Placement for Switched Reluctance Motors Active Damping (2009)

This paper describes the design and the placement of piezoelectric actuators on switched reluctance motors by means of a genetic algorithm (nondominated sorting genetic algorithm II) for the purpose of reducing stator vibrations. Two distinct approaches are presented: one energy-related and the other based on a minimization of the resultant displacement. These methods lead to design and placement strategy for the piezoelectric actuators. A number of optimal actuators obtained using these kinds of approaches is also compared with mechanical finite-element simulations. At last, a solution is achieved in order to validate optimal placement using positive position feedback active filtering.
Proton magnetic double-resonance study of angiotensin II (Asn1Val5) in aqueous solution employing correlation spectroscopy. Assignment of peptide NH resonances and transfer of saturation from water. (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProton magnetic double-resonance study of angiotensin II (Asn1Val5) in aqueous solution employing correlation spectroscopy. Assignment of peptide NH resonances and transfer of saturation from water.Jerry D. Glickson, Joseph Dadok, and Garland R. MarshallCite this: Biochemistry 1974, 13, 1, 11–14Publication Date (Print):January 1, 1974Publication History Published online1 May 2002Published inissue 1 January 1974https://pubs.acs.org/doi/10.1021/bi00698a002https://doi.org/10.1021/bi00698a002research-articleACS PublicationsRequest reuse permissionsArticle Views45Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Type 3c (pancreatogenic) diabetes mellitus secondary to chronic pancreatitis and pancreatic cancer (2016)

Diabetes mellitus is a group of diseases defined by persistent hyperglycaemia. Type 2 diabetes, the most prevalent form, is characterised initially by impaired insulin sensitivity and subsequently by an inadequate compensatory insulin response. Diabetes can also develop as a direct consequence of other diseases, including diseases of the exocrine pancreas. Historically, diabetes due to diseases of the exocrine pancreas was described as pancreatogenic or pancreatogenous diabetes mellitus, but recent literature refers to it as type 3c diabetes. It is important to note that type 3c diabetes is not a single entity; it occurs because of a variety of exocrine pancreatic diseases with varying mechanisms of hyperglycaemia. The most commonly identified causes of type 3c diabetes are chronic pancreatitis, pancreatic ductal adenocarcinoma, haemochromatosis, cystic fibrosis, and previous pancreatic surgery. In this Review, we discuss the epidemiology, pathogenesis, and clinical relevance of type 3c diabetes secondary to chronic pancreatitis and pancreatic ductal adenocarcinoma, and highlight several important knowledge gaps.
Multipath mitigation in high precision GPS systems using Artificial Magnetic Conductors (2014)

A low profile circularly polarized antenna based on Artificial Magnetic Conductor (AMC) ground plane is presented in this paper. The AMC ground plane is utilized to reduce the effects of multipath by blocking the propagation of surface waves. Hence, the proposed antenna is suitable for high precision GPS systems which require sub centimeter level of precision. Typically, choke ring antennas are used to efficiently reduce the effects of multipath interference. However, they are bulky, heavy and expensive. The antenna presented here consists of a microstrip antenna resonating at the L1 band (1.575 GHz) based on an 8×8 unit cells AMC structure; the result is an antenna showing good multipath rejection and a low axial ratio over a wide angular range. The advantage of the integrated AMC ground plane is the low cost of manufacturing, light weight, and a relatively low profile solution.
Sympathetic Control of Myocardial Oxygen Balance in Dogs Mediated by Activation of Coronary Vascular α2-Adrenoceptors (1985)

Recent observations on sympathetic constriction of the poststenotic coronary bed without dilatory reserve indicate the involvement of postsynaptic alpha 2-adrenoceptors, which are commonly regarded as noninnervated, hormonal receptors. Therefore, we characterized the vascular alpha-adrenoceptor activated during the competition between sympathetic constriction and metabolic dilation of the nonstenosed coronary bed by analyzing myocardial oxygen balance. In 39 anesthetized, spinalized open-chest dogs with bilateral cervical vagotomy, the left decentralized stellate ganglion was stimulated while mean aortic pressure was kept constant. Stimulation at 1 and 10 Hz lowered coronary venous oxygen saturation by 2.5 +/- 0.3 (SEM) and by 11.1 +/- 0.8 saturation %, respectively, in experiments under beta-blockade (4 mg/kg nadolol, n = 21). In experiments without beta-blockade (n = 18), the saturation response was similar. Under beta-blockade, alpha 2-blockade by rauwolscine (0.03 and 0.3 mg/kg) attenuated the decline in saturation induced by 10 Hz stimulation to 0.56 +/- 0.08 (p less than 0.01) of the control response and to 0.30 +/- 0.06 (p less than 0.001), respectively, whereas alpha 1-blockade by prazosin (0.012 and 0.12 mg/kg) modified this response only to 0.94 +/- 0.06 (NS) and to 0.75 +/- 0.08 (0.1 greater than p greater than 0.05). Without beta-blockade, similar attenuations to 0.36 +/- 0.07 (p less than 0.001) by 0.3 mg/kg rauwolscine and to 0.80 +/- 0.09 (NS) by 0.12 mg/kg prazosin were observed.(ABSTRACT TRUNCATED AT 250 WORDS)
Interview with James Bradner (2013)

James E Bradner is an Assistant Professor in Medicine at Harvard Medical School (MA, USA) as well as a Staff Physician in the Division of Hematologic Malignancies at Dana-Farber Cancer Institute (MA, USA). The present research focus of the Bradner laboratory concerns the discovery and optimization of prototype drugs targeting cancer gene regulation. The clinical objective of the Bradner group is to deliver novel therapeutics for human clinical investigation in hematologic diseases. Bradner's awards and honors include the Damon Runyon-Rachleff Innovation Award, the Smith Family Award for Excellence in Biomedical Research, the Dunkin' Donuts Rising Star Award and the HMS Distinguished Excellence in Teaching Award. He is a member of the American Society of Clinical Investigation, the American Society of Hematology, the American Chemical Society and the American Association of Cancer Research. His recent research has been published in Nature, Cell, Nature Chemical Biology and the Journal of the American Chemical Society. He has authored more than 20 US Patent applications, licensed to five pharmaceutical companies, and is a scientific founder of Acetylon Pharmaceuticals, SHAPE Pharmaceuticals, Tensha Therapeutics and Syros Pharmaceuticals. Bradner received his AB from Harvard University, his MD from the University of Chicago (IL, USA) and a MMS from Harvard Medical School. He completed his postgraduate training in Internal Medicine at Brigham & Women's Hospital (MA, USA), followed by a fellowship in Medical Oncology and Hematology at Dana-Farber Cancer Institute. Following additional post-doctoral training in Chemistry at Harvard University and the Broad Institute (MA, USA) with Professor Stuart Schreiber, Bradner joined the research faculty of Dana-Farber in 2008. Interview conducted by Hannah Coaker, Assistant Commissioning Editor.
ICDE 2008 PC Chairs Message (2008)

Presents the introductory welcome message from the conference proceedings.
Development of Hypointense Lesions on T1-Weighted Spin-Echo Magnetic Resonance Images in Multiple Sclerosis (1999)

Degree of inflammatory activity only partially predicted increase in T1 (and T2) lesion load at long-term follow-up. Initial T1 lesion load strongly contributed to subsequent increase in hypointense T1 lesion load, suggesting that there is a subpopulation of patients with multiple sclerosis who are prone to develop destructive lesions.
High-Q tunable bandstop filters with adaptable bandwidth and pole allocation (2011)

Summary form only given, as follows. Tunable bandstop filters are demonstrated with wide tuning ranges, tunable bandwidth, and a variable number of dynamically allocated poles. The number of poles can be dynamically applied at different frequencies to maximize isolation for a given interference scenario. These filters are made with evanescent-mode cavities which use a new loading post geometry that results in greater external coupling for a given physical coupling aperture size.
ChemInform Abstract: SYNTHESIS AND CHARACTERIZATION OF MULTIPLY SUBSTITUTED LACUNAR MACROBICYCLIC COMPLEXES OF NICKEL(II), A REPRESENTATIVE CRYSTAL STRUCTURE, AND PREPARATION OF CORRESPONDING FREE LIGANDS (1984)

Abstract Ausgehend von dem nach bekannter Methode dargestellten basischen acylierten Makrocyclus (Ia) wurden über zwei Stufen, wie bereits beschrieben, die Neutralkomplexe (Ib) erhalten, die durch Anwendung einer bereits für (Ia) beschriebenen Methode über die Methylvinylether (II) nach zwei von der Zugänglichkeit des Diamins abhängigen Methoden zu den gewünschten verbrückten Lacunar‐ Makrobicyclen (III) fuhren, wie am Beispiel der Darstellung von (IIIa) bzw. (IIIb) gezeigt wird.
Effects of sterilization with hydrogen peroxide gas plasma, ethylene oxide, and steam on bioadhesive properties of nylon and polyethylene lines used for stabilization of canine stifle joints (2012)

Effects of HPGP sterilization on bioadhesive properties of nylon and polyethylene lines compared favorably with those for ethylene oxide and steam sterilization. Also, nylon line may be a more suitable material than UHMWPE for suture prostheses on the basis of bacterial adherence properties.
Dieckol Attenuates Microglia-mediated Neuronal Cell Death via ERK, Akt and NADPH Oxidase-mediated Pathways (2015)

Excessive microglial activation and subsequent neuroinflammation lead to synaptic loss and dysfunction as well as neuronal cell death, which are involved in the pathogenesis and progression of several neurodegenerative diseases. Thus, the regulation of microglial activation has been evaluated as effective therapeutic strategies. Although dieckol (DEK), one of the phlorotannins isolated from marine brown alga Ecklonia cava, has been previously reported to inhibit microglial activation, the molecular mechanism is still unclear. Therefore, we investigated here molecular mechanism of DEK via extracellular signal-regulated kinase (ERK), Akt and nicotinamide adenine dinuclelotide phosphate (NADPH) oxidase-mediated pathways. In addition, the neuroprotective mechanism of DEK was investigated in microglia-mediated neurotoxicity models such as neuron-microglia co-culture and microglial conditioned media system. Our results demonstrated that treatment of anti-oxidant DEK potently suppressed phosphorylation of ERK in lipopolysaccharide (LPS, 1 µg/ml)-stimulated BV-2 microglia. In addition, DEK markedly attenuated Akt phosphorylation and increased expression of gp91 (phox) , which is the catalytic component of NADPH oxidase complex responsible for microglial reactive oxygen species (ROS) generation. Finally, DEK significantly attenuated neuronal cell death that is induced by treatment of microglial conditioned media containing neurotoxic secretary molecules. These neuroprotective effects of DEK were also confirmed in a neuron-microglia co-culture system using enhanced green fluorescent protein (EGFP)-transfected B35 neuroblastoma cell line. Taken together, these results suggest that DEK suppresses excessive microglial activation and microglia-mediated neuronal cell death via downregulation of ERK, Akt and NADPH oxidase-mediated pathways.
Editors’ Preamble to The Journal of Cardiovascular Aging (2021)

OAE Publishing Inc. is an international scholarly publisher specializing in peer-reviewed academic journals. To promote academic exchange and knowledge sharing, OAE provides an outstanding academic platform for biomedical experts and scholars all over the world.
Bistable Mechanisms for Space Applications (2016)

Compliant bistable mechanisms are monolithic devices with two stable equilibrium positions separated by an unstable equilibrium position. They show promise in space applications as nonexplosive release mechanisms in deployment systems, thereby eliminating friction and improving the reliability and precision of those mechanical devices. This paper presents both analytical and numerical models that are used to predict bistable behavior and can be used to create bistable mechanisms in materials not previously feasible for compliant mechanisms. Materials compatible with space applications are evaluated for use as bistable mechanisms and prototypes are fabricated in three different materials. Pin-puller and cutter release mechanisms are proposed as potential space applications.
Influencing Users Towards Better Passwords: Persuasive Cued Click-Points (2008)

Usable security has unique usability challenges because the need for security often means that standard human-computerinteraction approaches cannot be directly applied. An important usability goal for authentication systems is to support users in selecting better passwords, thus increasing security by expanding the effective password space. In click-based graphical passwords, poorly chosen passwords lead to the emergence of hotspots – portions of the image where users are more likely to select click-points, allowing attackers to mount more successful dictionary attacks. We use persuasion to influence user choice in click-based graphical passwords, encouraging users to select more random, and hence more secure, click-points. Our approach is to introduce persuasion to the Cued Click-Points graphical password scheme (Chiasson, van Oorschot, Biddle, 2007). Our resulting scheme significantly reduces hotspots while still maintaining its usability.
A biocompatibility study of new nanofibrous scaffolds for nervous system regeneration (2015)

The development of therapeutic approaches for spinal cord injury (SCI) is still a challenging goal to achieve. The pathophysiological features of chronic SCI are glial scar and cavity formation: an effective therapy will require contribution of different disciplines such as materials science, cell biology, drug delivery and nanotechnology. One of the biggest challenges in SCI regeneration is to create an artificial scaffold that could mimic the extracellular matrix (ECM) and support nervous system regeneration. Electrospun constructs and hydrogels based on self-assembling peptides (SAPs) have been recently preferred. In this work SAPs and polymers were assembled by using a coaxial electrospinning setup. We tested the biocompatibility of two types of coaxially electrospun microchannels: the first one made by a core of poly(ε-caprolactone) and poly(d,l-lactide-co-glycolide) (PCL-PLGA) and a shell of an emulsion of PCL-PLGA and a functionalized self-assembling peptide Ac-FAQ and the second one made by a core of Ac-FAQ and a shell of PCL-PLGA. Moreover, we tested an annealed scaffold by PCL-PLGA microchannel heat-treatment. The properties of coaxial scaffolds were analyzed using scanning electron microscopy (SEM), Fourier transform spectroscopy (FTIR), contact angle measurements and differential scanning calorimetry (DSC). In vitro cytotoxicity was assessed via viability and differentiation assays with neural stem cells (NSCs); whereas in vivo inflammatory response was evaluated following scaffold implantation in rodent spinal cords. Emulsification of the outer shell turned out to be the best choice in terms of cell viability and tissue response: thus suggesting the potential of using functionalized SAPs in coaxial electrospinning for applications in regenerative medicine.
Evaluation of Tooth Contact Stress With Tooth Flank Film Elements (Comparison of Evaluation With Measurement) (2007)

A new finite element analysis for meshing gear pair has been developed with a new element called “tooth flank film element.” The new element is a phantom element put on a tooth flank without any thickness, and enables boundary conditions for a contact problem in meshing teeth to be easily dealt with. In the present paper, contact stresses between tooth flanks of mating gear pair calculated with the proposed finite element method are compared with stresses measured with pressure measurement films. As a result, the proposed method was confirmed to be useful for evaluation of contact stress.
Urolithiasis, Endourology and Laparoscopy (2007)

No AccessJournal of UrologyAdult urology1 Sep 2007Urolithiasis, Endourology and Laparoscopy Ralph ClaymanM.D. Ralph ClaymanRalph Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2007.05.081AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 2007 by American Urological AssociationFiguresReferencesRelatedDetails Volume 178Issue 3September 2007Page: 822-824 Advertisement Copyright & Permissions© 2007 by American Urological AssociationMetricsAuthor Information Ralph Clayman More articles by this author Expand All Advertisement Loading ...