gebhart/patrepeval huggingface dataset:
Trajectory Planning for CubeSat Short-Time-Scale Proximity Operations (2014)

This paper considers motion planning for small satellites such as CubeSats performing proximity operations in a several meters range of a target object. The main goal is to develop a principled methodology for handling the coupled effects of orbital dynamics, rotational and translational rigid-body dynamics, underactuation and control bounds, and obstacle avoidance constraints. The proposed approach is based on constructing a reduced-order parameterization of the dynamics through dynamics inversion and differential flatness, and on efficient global optimization over a finite-dimensional reduced representation. Two simulated scenarios, a satellite reconfiguration maneuver and asteroid surface sampling, are developed to illustrate the approach. In addition, a simple two-dimensional experimental testbed consisting of an air-bearing table and two CubeSat engineering models is developed for partial testing and integration of the proposed methods.
Multi-Wire Interconnection: The Impact of the Lamination Process and the Encapsulant Properties on the Solder Joint Formation (2018)

Multi-wire designs for photovoltaic modules already proved its advantages in the past. In previous contributions, several multi-wire interconnection approaches were presented, both for back-contact [4] and 2-side contacted cells [4,5]. This paper reports the progress in the woven multi-wire interconnection which enables a combined lamination and soldering process using low-temperature melting point solder alloys. This work focuses on the solder joint formation and aims to correlate the viscoelastic properties of the encapsulant material during lamination with the electrical and visual characterisation of the solder joint. To do so, three analysis techniques are used: electroluminescence (EL) imaging, current-voltage (IV) measurements and a cross-section analysis. The aim is to optimize the lamination process and material selection for optimal solder joint formation. Rheological measurements on the encapsulation polymers revealed the viscosities at various temperatures. Small modules were fabricated and tested. According to the results of these tests, the optimal lamination temperature is around 165 ºC and at which the viscosity of the encapsulant should be at least 7500 Pa∙s. One of the tested encapsulant materials met these requirements and had the best electrical properties according to the EL-imaging and IV-measurements.
A modified electrode for the electrochemical reduction of isoflurane (1988)

The popular anaesthetic gas isoflurane is found to be electrochemically inert on a wide range of conventional electrode materials in both aqueous and non-aqueous solvents. However the chemically modified electrode produced by depositing the novel electroactive polymer, poly(vinylfluoranthene), onto a platinum electrode is shown to mediate electron transfer to the anaesthetic thus bringing about its electro-reduction and so offers the promise of amperometric electrochemical sensors based on this electrode.
A multisite phase III study of the safety and efficacy of a new manganese chloride‐based gastrointestinal contrast agent for MRI of the abdomen and pelvis (1999)

The purpose of this study was to evaluate the safety and efficacy of a manganese chloride-based oral magnetic resonance (MR) contrast agent during a Phase III multisite clinical trial. Two hundred seventeen patients were enrolled who were already scheduled for MRI of the abdomen and/or pelvis. In this group of patients, it was postulated that the use of an oral agent would better allow discrimination of pathology from bowel. Patients with known gastrointestinal pathology including peptic ulcer disease, inflammatory bowel disease, obstruction, or perforation were excluded to minimize confounding variables that could affect the safety assessment. Of these 217 patients, 18 received up to 900 mL of placebo, and 199 patients were given up to 900 mL of a manganese chloride-based oral contrast agent, LumenHance® (Bracco Diagnostics, Inc.). Safety was determined by comparing pre- and post-dose physical examinations, vital signs, and laboratory examinations and by documenting adverse events. Efficacy was assessed by unblinded site investigators and two blinded reviewers who compared pre- and post-dose T1- and T2-weighted MRI scans of the abdomen and/or pelvis. In 111 (57%) of the 195 cases evaluated for efficacy by site investigators (unblinded readers), MRI after LumenHance provided additional diagnostic information. Increased information was found by two blinded readers in 52% and 51% of patients, respectively. In 44/195 cases (23%) unblinded readers felt the additional information would have changed patient diagnosis and in 50 patients (26%), it would have changed management and/or therapy. Potential changes in patient diagnosis or management/therapy were seen by the two blinded readers in 8–20% of patients. No clinically significant post-dose laboratory changes were seen. Forty-eight patients (24%) receiving LumenHance and four patients (22%) receiving placebo experienced one or more adverse events. Gastrointestinal tract side effects were most common, seen in 29 (15%) of LumenHance patients and in 3 (17%) of the placebo patients. LumenHance is a safe and efficacious oral gastrointestinal contrast agent for MRI of the abdomen and pelvis.J. Magn. Reson. Imaging 1999;10:15–24. © 1999 Wiley-Liss, Inc.
Clean Energy Manufacturing Initiative Solid-State Lighting Video (2014)

The importance of U.S. manufacturing for clean energy technologies, such as solid-state lighting (SSL), is paramount to increasing competitiveness in a global marketplace. SSLs are poised to drive the lighting market, worldwide. In order to continue that competitiveness and support further innovation, the time to invest in U.S. manufacturing of clean energy technologies is now. Across the country, companies developing innovative clean energy technologies find competitive advantages to manufacturing in the U.S. The Department of Energy's Building Technology Office SSL Manufacturing Roadmap is just one example of how we support manufacturing through convening industry perspectives on opportunities to significantly reduce risk, improve quality, increase yields, and lower costs.
Chemotaxis of Burkholderia sp. Strain SJ98 towards chloronitroaromatic compounds that it can metabolise (2012)

Burkholderia sp. strain SJ98 exhibits metabolic transformation of, and inducible chemotaxis towards CNACs. Its chemotactic responses towards these compounds are related to its previously demonstrated chemotaxis towards NACs that it can metabolise, but it is independently inducible from its chemotaxis towards succinate or aspartate.
Structure of ACLY in complex with CoA (2019)

ATP-citrate lyase (ACLY) synthesizes cytosolic acetyl coenzyme A (acetyl-CoA), a fundamental cellular building block. Accordingly, aberrant ACLY activity is observed in many diseases. Here we report cryo-EM structures of human ACLY, alone or bound to substrates or products. ACLY forms a homotetramer with a rigid citrate synthase homology (CSH) module, flanked by four flexible acetyl-CoA synthetase homology (ASH) domains; CoA is bound at the CSH-ASH interface in mutually exclusive productive or unproductive conformations. The structure of a catalytic mutant of ACLY in the presence of ATP, citrate and CoA substrates reveals a phospho-citryl-CoA intermediate in the ASH domain. ACLY with acetyl-CoA and oxaloacetate products shows the products bound in the ASH domain, with an additional oxaloacetate in the CSH domain, which could function in ACLY autoinhibition. These structures, which are supported by biochemical and biophysical data, challenge previous proposals of the ACLY catalytic mechanism and suggest additional therapeutic possibilities for ACLY-associated metabolic disorders.
Senescence‐accelerated Mouse Displays Aberrant Bone Metal Composition (1996)

Senescence-accelerated mouse (SAM) is a genetically controlled mouse strain which has been used as a murine model of accelerated senescence, including osteoporosis, and aging-related neural disorders. To analyse the pathogenic changes in bone during senescence, we have measured bone metal composition in normal mice and SAM mouse.



SAM-P/6 mice showed significant changes in zinc (21% increase) and silicon (43% decrease) compared with the control senescence-resistant mouse (SAM-R/1). The average measured values were: Zn 147 μg g−1; Fe 100 μg g−1; Ca 73 mg g−1; S 2.0 mg g−1; P 93 mg g−1; Si 531 μg g−1; Mg 2.8 mg g−1; Na 731 μg g−1 for the SAM-R1 strain, and Zn 179 μg g−1; Fe 105 μg g−1; Ca 80 mg g−1; S 2.1 mg g−1; P 95 mg g−1; Si 299 μg g−1; Mg 3.0 mg g−1; Na 750 μg g−1 for the SAM-P/6 strain. Calcium phosphate is a major form of calcium stock in bones, but neither Ca nor P displayed marked changes between the two strains. Likewise, both strains had similar amounts of other elements (Fe, S and Na).



At present, it is unclear whether the increase of zinc in the SAM-P/6 mouse is a result of an aberrant biochemical process or is causative of the modification of activities of crucial proteins, enzymes for bone metabolism. It also is not yet clear whether the accumulation of silicon is a primary event during bone-related pathogenesis in SAM-P/6 mice.
SPEECH PRODUCTTON MODELLING WITH VARIABLE (2010)

cognition and synthesis of speech require curate models of speech production. Inherent in near predictive modelling is the assumption that e formant frequencies and bandwidths of speech not change within the analysis frame - usually least a larynx cycle. It is shown that there n be significant differences in formant haracteristics between the closed and open glottis phases of the larynx cycle. A development of the lossless tube model is presented in which the formant variations between closed and open glottis phases are modelled by a time varying glottal reflection coefficient. A numerically based method for estimating the parameters of such a model is outlined. The results of analysis and re-synthesis of female voiced speech obtained using this model are compared to those obtained using conventional LPC. ly used models of speech production tract by a linear predictor models - parametrically described coefficients - can give excellent ch coding applications. However, three simplifying assumptions, normally inherent in linear predictive models of the vocal tract, may lead to model inaccuracies which are more serious in recognition and synthesis applications than in coding. vocal
Development of femtosecond random gratings for fiber laser and sensor applications (2021)

We report the use of a femtosecond infrared (fs-IR) laser to produce random grating structures in optical fibers for fiber sensor and fiber laser applications. The plane-by-plane method of inscribing various gratings is presented. We review our experimental results over the past 5 years of the applications of fiber random gratings for distributed temperature measurements, fiber lasers and fiber laser sensors. The potential applications of fs-IR laser processed optical fibers in structure health monitoring, harsh environment sensing, perimeter intrusion detection and encrypted communication will be discussed.
Unitized regenerative fuel cell systems (1998)

Energy storage systems with extremely high specific energy (>400 Wh/kg) have been designed that use lightweight pressure vessels to contain the gases generated by reversible (unitized) regenerative fuel cells (URFCs).[1] URFC systems are being designed and developed for a variety of applications, including high altitude long endurance (HALE) solar rechargeable aircraft (SRA), zero emission vehicles (ZEVs), hybrid energy storage/propulsion systems for spacecraft, energy storage for remote (off-grid) power sources, and peak shaving for on-grid applications.[1-10] Energy storage for HALE SRA was the original application for this set of innovations, and a prototype solar powered aircraft (Pathfinder-Plus) recently set another altitude record for all propeller-driven aircraft on August 6, 1998, when it flew to 80,285 feet (24.47 km).[11]
Breast cancer outcome prediction with tumour tissue images and machine learning (2019)

Our findings demonstrate the feasibility of learning prognostic signals in tumour tissue images without domain knowledge. Although further validation is needed, our study suggests that machine learning algorithms can extract prognostically relevant information from tumour histology complementing the currently used prognostic factors in breast cancer.
Rotational spectrum and structure of the Ar3–HCl symmetric top (1987)

The Ar3–HCl tetramer has been identified via the observation of its microwave rotational spectrum using the pulsed nozzle Fourier transform technique. The rotational spectroscopic constants of the ground vibrational state have been obtained for the 35Cl/37Cl isotopes from measurements of the J=1→2 to J=4→5 transitions and their hyperfine structure. For Ar3–H35Cl, the values found for B0, DJ, DJK, and χaa are 843.8974(1) MHz, 2.333(2) and 1.818(6) kHz, and 31.006(5) MHz, respectively, and for Ar3–H37Cl, 825.9811(2) MHz, 2.211(5) and 1.940(12) kHz, and 24.481(8) MHz. The cluster is a symmetric top with the HCl along the C3 axis, its H end directed towards the Ar3 trimer. In its torsional oscillations, the HCl makes an average angle of 36.91° with the symmetry axis. The chlorine isotopic substitution leads to values of 3.8510 and 4.0024 Å for the Ar–Ar and Ar–Cl distances. The results of the present study are compared with those reported earlier for the Arm–HF (m=1,2,3) and Arm–HCl (m=1,2) clusters.
Upward continuation for clutter suppression in EMI sensing of subsurface UXO (2009)

Clutter is the bane of electromagnetic induction (EMI) surveying for subsurface unexploded ordnance (UXO) under realistic circumstances. Relatively small near-surface metallic items can still produce significant signals simply because they are much closer to the sensor than the larger underlying target of interest. Based on measured, fully multi-static, scalar data at some typical elevation above the ground, one may infer a surface layer of equivalent sources that will produce that data. Without having to locate or characterize the actual targets, one can use these equivalent sources to predict complete vector field data that would be obtained at any elevation equal to or greater than that of the original data. Such computational upward continuation (UC) of signals successfully suppressed clutter in field data. This was even the case when the local clutter signal was significantly stronger than that of the broader underlying UXO response and was embedded directly within it. The success of the approach is directly tied to the fact that it relies on the governing physics.
‘Masked synthons’ in crystal engineering: insulated components in acetaminophen cocrystal hydrates (2013)

A series of cocrystals of acetaminophen and trans-1,2-bis(4-pyridyl)ethylene are reported wherein there is a lack of direct hydrogen-bonding between the components owing to interjected water molecules. A survey of the Cambridge Structural Database demonstrates that interjected water molecules involving cocrystals with similar components are rare. We term the lack of interaction as a ‘masked synthon’, which we aim to contribute to the development of synthon theory in organic solid-state chemistry.
Conditional Disruption of Calcineurin B1 in Osteoblasts Increases Bone Formation and Reduces Bone Resorption (2007)

We recently reported that the pharmacological inhibition of calcineurin (Cn) by low concentrations of cyclosporin A increases osteoblast differentiation in vitro and bone mass in vivo. To determine whether Cn exerts direct actions in osteoblasts, we generated mice lacking Cnb1 (Cn regulatory subunit) in osteoblasts (DeltaCnb1(OB)) using Cre-mediated recombination methods. Transgenic mice expressing Cre recombinase, driven by the human osteocalcin promoter, were crossed with homozygous mice that express loxP-flanked Cnb1 (Cnb1(f/f)). Microcomputed tomography analysis of tibiae at 3 months showed that DeltaCnb1(OB) mice had dramatic increases in bone mass compared with controls. Histomorphometric analyses showed significant increases in mineral apposition rate (67%), bone volume (32%), trabecular thickness (29%), and osteoblast numbers (68%) as well as a 40% decrease in osteoclast numbers as compared with the values from control mice. To delete Cnb1 in vitro, primary calvarial osteoblasts, harvested from Cnb1(f/f) mice, were infected with adenovirus expressing the Cre recombinase. Cre-expressing osteoblasts had a complete inhibition of Cnb1 protein levels but differentiated and mineralized more rapidly than control, green fluorescent protein-expressing cells. Deletion of Cnb1 increased expression of osteoprotegerin and decreased expression of RANKL. Co-culturing Cnb1-deficient osteoblasts with wild type osteoclasts demonstrated that osteoblasts lacking Cnb1 failed to support osteoclast differentiation in vitro. Taken together, our findings demonstrate that the inhibition of Cnb1 in osteoblasts increases bone mass by directly increasing osteoblast differentiation and indirectly decreasing osteoclastogenesis.
Correlation between ultrasonographic findings and serum testosterone concentration in prepubertal and peripubertal colts (1994)

Correlation between serum testosterone concentration and morphometric findings from ultrasonography of the accessory sex glands in peripubertal colts was investigated during pubertal development. Nineteen colts of initial age ranging from 5 to 12 months were monitored over a 13-month period. Serum testosterone concentration was determined on a biweekly basis, and accessory sex gland development was ultrasonographically monitored once a month. Notwithstanding individual variation, there was significant correlation (r = 0.913; P < 0.01) between increasing serum testosterone concentration and the onset of developmental changes involving the accessory sex glands. As colts entered their 2-year-old year with relatively immature reproductive tracts, compared with mature stallions, there was still a significant seasonal effect on serum testosterone concentration and accessory sex gland measurements (P < 0.05). Ultrasonography was confirmed as a valuable noninvasive method of monitoring and assessing peripubertal accessory sex gland development in colts.
Plasma Lipid Profiling Shows Similar Associations with Prediabetes and Type 2 Diabetes (2013)

The relationship between lipid metabolism with prediabetes (impaired fasting glucose and impaired glucose tolerance) and type 2 diabetes mellitus is poorly defined. We hypothesized that a lipidomic analysis of plasma lipids might improve the understanding of this relationship. We performed lipidomic analysis measuring 259 individual lipid species, including sphingolipids, phospholipids, glycerolipids and cholesterol esters, on fasting plasma from 117 type 2 diabetes, 64 prediabetes and 170 normal glucose tolerant participants in the Australian Diabetes, Obesity and Lifestyle Study (AusDiab) then validated our findings on 1076 individuals from the San Antonio Family Heart Study (SAFHS). Logistic regression analysis of identified associations with type 2 diabetes (135 lipids) and prediabetes (134 lipids), after adjusting for multiple covariates. In addition to the expected associations with diacylglycerol, triacylglycerol and cholesterol esters, type 2 diabetes and prediabetes were positively associated with ceramide, and its precursor dihydroceramide, along with phosphatidylethanolamine, phosphatidylglycerol and phosphatidylinositol. Significant negative associations were observed with the ether-linked phospholipids alkylphosphatidylcholine and alkenylphosphatidylcholine. Most of the significant associations in the AusDiab cohort (90%) were subsequently validated in the SAFHS cohort. The aberration of the plasma lipidome associated with type 2 diabetes is clearly present in prediabetes, prior to the onset of type 2 diabetes. Lipid classes and species associated with type 2 diabetes provide support for a number of existing paradigms of dyslipidemia and suggest new avenues of investigation.
Liposomes for targeted delivery of radioiodinated IVdU and 3-CH3-IVdU for non-invasive detection of herpes simplex virus encephalitis in mice. (1988)

Liposomal encapsulation of radioiodinated anti-herpes nucleosides was undertaken to reduce metabolic inactivation and increase blood-brain barrier penetration of the nucleosides, and so provide formulations suitable for use in the non-invasive scintigraphic diagnosis of herpes simplex encephalitis (HSE). The nucleosides investigated were [125I]-IVdU and its more lipophilic 3-methyl derivative, and they were encapsulated in phosphatidylcholine:cholesterol:sulfatide liposomes with an efficiency of 4.4% and 1.7% respectively. The encapsulation of IVdU reduced in vitro phosphorolysis (by 31% in serum at 25 degrees C over 3 hr as compared with non-encapsulated IVdU), and markedly increased in vivo stability (fifty-fold greater than that of free drug). In normal mice, higher radioactivity levels were observed in most tissues and there was prolonged, constant blood and brain uptake. Biodistribution of liposomal IVdU in herpes simplex virus (HSV) infected animals was similar, but somewhat lower concentrations were attained. Liposomal encapsulation of [125I]-3-CH3-IVdU produced less dramatic changes in tissue distribution in either healthy or HSV infected mice, as compared with the non-encapsulated drug. Whilst, in HSV infected mice, liposomal encapsulation of both drugs caused increased uptake by spleen, liver and lung, the uptake by brain was still too low for detection by whole-body scintigraphy.
Velocardiofacial manifestations and microdeletions in schizophrenic inpatients (1997)

Velocardiofacial syndrome (VCFS) is associated with an increased frequency of schizophrenia and other types of psychiatric morbidity. In this study, we tried to identify a subgroup of schizophrenic patients with deletions in the VCFS region of the long arm of chromosome 22. For that purpose, we screened the records of two major general hospitals for patients with abnormalities characteristic of VCFS, such as cardiac anomalies and cleft palate, and cross-checked the data with the register of psychiatric hospitalizations in four psychiatric hospitals. Of the 24 patients that qualified, only seven patients could be studied. An additional eight schizophrenic inpatients were ascertained clinically, based on a working VCFS Clinical Scale. FISH studies and molecular analyses, using polymorphic markers from the VCFS region, documented hemizygosity of 22q11 in three out of 15 patients (20.0%). Increased awareness of psychiatrists to signs of VCFS among patients with psychiatric illnesses is encouraged, in order to direct molecular studies effectively. In order to cut down the cost of testing, we suggest screening suspected patients with a single marker, such as D22S941, and to study further only those who have a single electrophoretic band. Am. J. Med. Genet. 72:455–461, 1997. © 1997 Wiley-Liss, Inc.
High levels of soluble CD40 ligand and matrix metalloproteinase-9 in serum are associated with favorable clinical evolution in human visceral leishmaniasis (2013)

Serum sCD40L and MMP-9 are identified as new and simple biomarkers in two situations: (i) monitoring the success of therapy and (ii) predicting favorable clinical outcome of human VL.