gebhart/patrepeval huggingface dataset:
Lessons learned from the deployment of a multihop IEEE 802.11g testbed using COTS devices (2010)

A lot of attention has been given to multihop wireless networks lately, but further research is needed. This attention has motivated an increase in the number of 802.11-based deployments, both indoor and outdoor. These testbeds are used to run measurements in order to analyze and understand the limitation and differences between analytical or simulation-based figures and the results from real-life experimentation. In this paper we describe the lessons learned from the deployment of a wireless multihop testbed under the false floor of a laboratory in our Computer Science building. We assess the radio shielding provided by the false floor panels, and run exhaustive and controlled experiments to analyze the performance limits of commercial off-the-shelf hardware. The results obtained confirm that experimental measurements can severely deviate from the expected theoretical values.
Stress relaxation and dynamic viscoelastic properties of end‐linked poly(dimethyl siloxane) networks containing unattached poly(dimethyl siloxane) (1981)

Abstract Stress relaxation in uniaxial extension and dynamic shear moduli G′ and G″ have been studied in networks of vinyl‐terminated poly(dimethyl siloxane) (PDMS) of five different molecular weights ( M n from 1800 to 29,200) crosslinked with cis ‐dichlorobis (diethyl sulfide) platinum (II) and containing 10 and 15 wt % of two samples of high‐molecular‐weight unattached linear hydroxyl‐terminated PDMS ( M w 700,000 and 950,000). The M w / M n ratio of both the network prepolymers and the unattached linear species was approximately 2. In stress relaxation the stretch ratio was 1.25 or less and the shear relaxation modulus was calculated from the neo‐Hookean stress‐strain relation. In the dynamic measurements, the strain amplitude was 15% or less; after conversion to the timedependent shear relaxation modulus G ( t ) the two sets of measurements were combined and the contribution of the unattached species G 1 ( t ) was calculated by difference. After multiplication by (1 − v ) −1 G / G e , where v 2 is the volume fraction of network, G is the plateau modulus of the uncrosslinked polymer, and G e is the equilibrium modulus of the network containing unattached molecules, G 1 ( t ) was compared with G 11 ( t ), the relaxation modulus was essentially the same in both environments. The relaxation was slower in the networks than in the uncrosslinked polymer by 1 to 2 orders of magnitude, and it increased gradually with increasing G e , which is a measure of total to pological obstacles represented by crosslinks plus trapped entanglements. A similar but less striking difference between relaxation in a network and in the homologous environment of a linear polymer was previously observed in end‐linked polybutadiene networks and the butadiene phase of a styrene‐butadiene‐styrene block copolymer. It appears that, in these systems where the topology of the obstacles is fixed, the reptation is severely restricted or else alternative modes of configurational rearrangement which contribute to relaxation in the uncrosslinked polymer are suppressed.
Chiroptical Properties of Chiral Substituted Polyfluorenes (2002)

Liquid-crystalline polyfluorene (PF) homopolymers substituted with chiral alkyl side chains were synthesized, and their chiroptical properties in the solid state were investigated by means of circular dichroism (CD), circularly polarized photoluminescence (CPPL), and circularly polarized electroluminescence (CPEL) measurements. Polarization-selective scattering of light is shown to cause artifacts in the circularly polarized absorption and emission spectra in the wavelength range near or above the absorption edge, and a measurement scheme to avoid these is presented. For all derivatives, significant chiroptical effects appeared only after the solid layers have been annealed at elevated temperatures, preferably into the liquid-crystalline state of the polymer. The largest anisotropy factors were measured for a polyfluorene substituted with chiral (R)-2-ethylhexyl side chains, yielding absolute values of up to 0.28 for CPPL and up to 0.25 for CPEL. These are among the highest ever reported for a chiral conjugated polymer. Anisotropy factors for CD, CPEL, and CPPL were consistently found to follow an “odd−even effect” concerning the position of the chiral center in the alkyl side chain. If the chiral center is placed close to the polymer backbone, the CD is dominated by one peak with its maximum close to the maximum of the π−π* absorption band. This indicates that the chiroptical properties are most probably caused by intrachain effects rather than by pure interchain exciton coupling. This interpretation is supported by the results of time-dependent Hartree−Fock calculations for the isolated fluorene dimer and trimer. In both cases, the anisotropy factor depends strongly on the torsion angle between neighboring fluorene units. For the trimer, a maximum anisotropy factor of 0.25, close to the maximum values determined experimentally, is predicted for a torsion angle of ca. 105°. Both experimental and theoretical results indicate that the chiroptical properties of these chiral substituted polyfluorenes are mainly caused by a helical conformation of the conjugated polymer backbone.
Advertising Entanglement Capabilities in Quantum Networks (2019)

This document describes the use of link-state routing protocols on
classical links in Quantum Networks. It contains proposals for
additions to the IS-IS and OSPF protocols in order for them to
transport relevant information for a Quantum Network, specifically,
for the creation and manipulation of entangled pairs. The document
will describe some of the necessary attributes and some suggestions of
how this information may be used. No Schrodinger's cats were
harmed in the creation of this document.
Effect of Puberty on the Pharmacodynamic and Pharmacokinetic Properties of Insulin Pump Therapy in Youth With Type 1 Diabetes (2007)

Development of biosynthetic techniques for production of human insulin enabled the pharmaceutical industry to produce rapid-acting insulin analogs that are more rapidly absorbed following subcutaneous injection than regular insulin (1–5). These analogs may be especially useful in treating adolescents with type 1 diabetes who require large premeal bolus doses due to the peripheral insulin resistance of puberty (6). When used in large doses, the peak action of regular insulin is delayed (to 3–4 h) and the duration markedly prolonged (to 8 h or more) (7). The pharmacokinetic and pharmacodynamic properties of the rapid-acting insulin analogs have not been well studied in pediatric patients or when administered by continuous subcutaneous insulin infusion. This study was undertaken to examine the effect of puberty on the pharmacokinetics and -dynamics of aspart insulin in pump-treated patients.

A total of 21 healthy nonobese subjects with type 1 diabetes ranging in age from 8 to 17 years were studied. All were receiving continuous subcutaneous insulin infusion therapy and had A1C levels between 6.5 and 8.9%. The Yale Human Investigation Committee approved the study; written informed consent was obtained from the parents and assent from the subjects. Subjects were divided into two groups: prepubertal (Tanner stage I, n = 9) and pubertal (Tanner stages II–V, n = 12). The two groups did not differ significantly in A1C levels, duration of diabetes, and BMI percentiles. Daily insulin doses were available in …
Proton n.m.r. investigation of conformational influence of penicillamine residues on the disulfide ring system of opioid receptor selective Somatostatin derivatives (1988)

Three cyclic disulfide analogs related to somatostatin, D-Phe(1)-cyclo(Cys(2)-Tyr(3)-D-Trp(4)-Lys(5)-Thr(6)-Xxx(7))-Thr(8)- NH2 (where Xxx = L-Pen 1; L-Cys 3; or D-Pen 4) were examined in DMSO-d6 by one- and two-dimensional proton n.m.r. spectroscopy in order to analyze the conformational influence of the position-7 residue on the 20-membered disulfide ring. From these studies it was concluded that all three analogs maintain a beta II' turn solution conformation for the core tetrapeptide -Tyr(3)-D-Trp(4)-Lys(5)-Thr(6)-. However, the disulfide conformation differs in the analogs, with 1 and 3 having a left-handed and 4 a right-handed disulfide chirality.
GLP-1/GIP analogs: potential impact in the landscape of obesity pharmacotherapy (2023)

GLP-1R mimetics are often discontinued within 24 months meaning long-term application of these agents in obesity is questioned. Combined GIPR/GLP-1R agonism appears to induce fewer side effects, indicating GLP-1R/GIPR co-agonists may be more suitable for enduring obesity management. After years of debate, this GIPR-biased GLP-1R/GIPR co-agonist highlights the therapeutic promise of including GIPR modulation for diabetes and obesity therapy.
SU‐FF‐J‐28: A Software Tool for On‐Line Real‐Time Verification of Gated Delivery Using Megavoltage Fluoroscopy (2007)

Purpose: To test and to explore the application of a software tool developed for on‐line real‐time treatment verification for 4D/gated radiation delivery using megavoltage fluoroscopy (MVF) acquired with treatment beams. Method and Materials: MVF images were acquired with a flat panel detector installed on a Siemens Linac using 6MV photon beams for phantoms with moving structures and for thoracic cancer patients. A previously developed software, RTReg4D, was used to register acquired MVF with digitally reconstructed radiographs (DRRs) from 4DCT. The MVF frame grabber can be synchronized with the gating signal from Anzai gating device to capture target motion in selected gating window. The isocenter and target contours were transferred from a planning system into RTReg4D and were overlaid on the MVF images, verifying whether the target with residual motion is adequately covered during the gated delivery. Appropriate actions can be initiated should the verification fail. Results: The software tool can effectively and accurately register MVF images with DRRs. The MVF images acquired with a dose as low as 1 cGy were adequate for the registration. In addition, the registration can be performed between the averaged MVF frame of all frames acquired within gating window and the corresponding DRR, further reducing dose required. The accuracy of registration can be better than 3 mm. The entire process is fast. Conclusion: MVF achieves adequate image quality at a low dose. It is practically feasible to use the software tool with MVF for real‐time (prior or during) treatment verification of 4D/gated radiation delivery. Conflict of Interest: This work is sponsored in part by Siemens OCS.
The P4−P6 Domain Directs Higher Order Folding of the Tetrahymena Ribozyme Core (1997)

The active site of group I self-splicing introns occurs at the interface of two proposed structural domains. In the Tetrahymena intron, half of the catalytic core resides within the independently-folding P4-P6 domain while the other half belongs to a putative domain that includes helices P3, P7, P8, and P9 (P3-P9). To determine whether the P3-P9 region of the intron can also fold independently, we used Fe(II)-EDTA and dimethyl sulfate to probe the solvent accessibility of separate fragments of the Tetrahymena intron. These RNAs self-assemble into an active complex in trans, enabling analysis of their structural features both alone and within the complex. Our results show that while the P3-P9 region of the intron retains its secondary structure, most of the tertiary interactions within this region do not form stably in the absence of the P4-P6 domain. This indicates that the P4-P6 domain induces folding in the P3-P9 region, organizing the catalytic cleft between them. Thus the P4-P6 domain provides a scaffold for the folding of the Tetrahymena intron core.
MIMO Radar Processing Methods for Anticipating and Preventing Real World Imperfections (2015)

The MIMO radar concept promises numerous advantages compared to today's radar architectures: flexibility for the transmitting beampattern design - including wide scene illumination and fine resolution after processing - and system complexity reduction, through the use of less antennas and the possibility to transfer system control and calibration to the digital domain. However, the MIMO radar is still at the stage of theoretical concept, with insufficient consideration for the impacts of waveforms' lack of orthogonality and system hardware imperfections.The ambition of this thesis is to contribute to paving the way to the operational MIMO radar. In this perspective, this thesis work consists in anticipating and compensating the imperfections of the real world with processing techniques. The first part deals with MIMO waveform design and we show that phase code waveforms are optimal in terms of spatial resolution. We also exhibit their limits in terms of sidelobes appearance at matched filter output. The second part consists in taking on the waveform intrinsic imperfections and proposing data-dependent processing schemes for the rejection of the induced residual sidelobes. We develop an extension for the Orthogonal Matching Pursuit (OMP) that satisfies operational requirements, especially localization error robustness, low computation complexity, and nonnecessity of training data. The third part deals with processing robustness to signal model mismatch, especially how it can be prevented or anticipated to avoid performance degradation. In particular, we propose a digital method of transmitter phase calibration. The last part consists in carrying out experiments in real conditions with the Hycam MIMO radar testbed. We exhibit that some unanticipated encountered distortions, even when limited at the matched filter output, can greatly impact the performance in detection of the data-dependent processing methods.
Theoretical and experimental results for 1550-nm light scattering in clouds and their predictions for pulse broadening effects on high-throughput optical communications (2009)

We present theoretical and experimental results for the expected impact on high-throughput optical communication systems of pulse broadening effects from scattered light propagating through water-based clouds. Existing analytical models are compared with experimental results. A preferred Monte Carlo model is developed and validated from field measurements of off-axis scattering through clouds, using a low-power continuous wave laser source at 1550 nm wavelength. This model is used in the time domain to examine the effects of pulse broadening for Gigabit and higher systems with practical apertures and fields of view. Results indicate that, for most current scenarios, pulse stretching may not cause significant inter-symbol interference.
Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology (2012)

Extracellular volume fraction imaging can quantitatively characterize myocardial infarction, atypical diffuse fibrosis, and subtle myocardial abnormalities not clinically apparent on LGE images. Taken within the context of prior literature, these subtle ECV abnormalities are consistent with diffuse fibrosis related to age and changes remote from infarction.
Fabrication of Highly Conductive 12CaO×7Al2O3 Thin Films Encaging Hydride Ions by Proton Implantation. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Impact of Eimeria meleagrimitis and intermittent amprolium treatment on performance and the gut microbiome composition of Turkey poults (2023)

VX did not affect performance during the pre-challenge period. At d23-29 (post-challenge), VX groups had significantly (<i>P</i> < 0.05) higher BWG than the PC group. Contacts and directs of VX groups in LS had significantly reduced compared to PC. As anticipated, amprolium treatment markedly reduced fecal and litter OPG for the VX + Amprol group compared to the VX group which did not receive amprolium. The ileal and cecal content results showed that the PC group had different bacterial diversity and structure, including alpha and beta diversity, compared to NC. Linear discriminant analysis Effect Size (LEfSe) identified that <i>Lactobacillus salivarius</i> (ASV2) was enriched in PC's ileal and cecal content. Compared to NC and PC, the vaccinated groups showed no distinct clusters, but there were similarities in the ileal and cecal communities based on Bray-Curtis and Jaccard distances. In conclusion, these results indicate that vaccination with this strain of <i>E. meleagrimitis</i>, with or without amprolium intervention, caused a very mild infection that induced protective immunity and challenge markedly affected both the ileal and cecal microbiome.
Unbound free fatty acid profiles in human plasma and the unexpected absence of unbound palmitoleate (2017)

We determined for the first time the profiles of the nine most abundant unbound FFAs (FFAus) in human plasma. Profiles were determined for a standard reference plasma of pooled healthy adults for which the Lipid MAPSMAPS Consortium had determined the total FFA profiles. Measurements were performed by using 20 different acrylodan-labeled fatty acid binding protein mutants (probes), which have complementary specificities for the nine FFAs that comprise more than 96% of long-chain plasma FFA. The acrylodan fluorescence emission for each probe changes upon binding a FFAu. The plasma concentrations of each of the nine FFAus were determined by combining the measured fluorescence ratios of the 20 probes. The total molar FFAu concentration accounted for <10<sup>-5</sup> of the total FFA concentration, and the mole fractions of the FFAu profiles were substantially different than the total FFA profiles. Myristic acid, for example, comprises 22% of the unbound versus 2.8% of the total. The most surprising difference is our finding of zero unbound <i>cis</i>-9-palmitoleic acid (POA), whereas the total POA was 7.2%. An unidentified plasma component appears to specifically prevent the release of POA. FFAus are the physiologically active FFAs, and plasma FFAu profiles may provide novel information about human health.
Bone marrow immunophenotyping by flow cytometry in refractory cytopenia of childhood (2014)

Refractory cytopenia of childhood is the most common type of childhood myelodysplastic syndrome. Because the majority of children with refractory cytopenia have a normal karyotype and a hypocellular bone marrow, differentiating refractory cytopenia from the immune-mediated bone marrow failure syndrome (very) severe aplastic anemia can be challenging. Flow cytometric immunophenotyping of bone marrow has been shown to be a valuable diagnostic tool in differentiating myelodysplastic syndrome from non-clonal cytopenias in adults. Here, we performed the first comprehensive flow cytometric analysis of immature myeloid, lymphoid cells and erythroid cells, and granulocytes, monocytes, and lymphoid cells in bone marrow obtained from a large prospective cohort of 81 children with refractory cytopenia. Children with refractory cyotopenia had a strongly reduced myeloid compartment, but not as severe as children with aplastic anemia. Furthermore, the number of flow cytometric abnormalities was significantly higher in children with refractory cytopenia than in healthy controls and in children with aplastic anemia, but lower than in advanced myelodysplastic syndrome. We conclude that flow cytometric immunophenotyping could be a relevant addition to histopathology in the diagnosis of refractory cytopenia of childhood. (The multi-center studies EWOG-MDS RC06 and EWOG-MDS 2006 are registered at clinicaltrials.gov identifiers 00499070 and 00662090, respectively).
Bright-field quantitative phase microscopy (BFQPM) for accurate phase imaging using conventional microscopy hardware (2015)

ABSTRACT Most quantitative phase microscopy methods require the use of custom-built or modified microscopic configurations which are not typically available to most bio/pathologists. There are, however, phase retr ieval algorithms which utilize defocused bright-field images as input data and are therefore implementable in existing laboratory environments. Among these, deterministic methods such as those based on inverting the transport-of-intensity equation (TIE) or a phase contrast transfer function (PCTF) are particularly attractive due to their compatibility with Kohler illuminated systems and numerical simplicity. Recently, a new method has been proposed, called multi -filter phase imaging with partially coherent light (MFPI-PC), which alleviates the inherent noise/resolution trade-off in solving the TIE by utilizing a large number of defocused bright-field images spaced equally about the focal plane. Despite greatly improving the state-of-the-art, the method has many shortcomings including the im practicality of high-speed acquisition, inefficient sampling, and attenuated response at high frequencies due to aperture effects. In this report, we present a new method, called bright-field quantitative phase microscopy (BFQPM), which efficiently utilizes a small number of defocused bright-field images and recovers frequencies out to the partially coherent diffraction limit. The method is based on a noise-minimized inversion of a PCTF derived for each finite defo cus distance. We present simulation results which indicate nanoscale optical path length sensitivity and improved performance over MFPI-PC. We also provide experimental results imaging live bovine mesenchymal stem cells at sub-se cond temporal resolution. In all, BFQPM enables fast and accurate phase imaging with unprecedented spatial resolution using widely availa ble bright-field microscopy hardware. Keywords: Quantitative phase imaging, phase retrieval, im age reconstruction techniques, partial coherence
ChemInform Abstract: Prodrugs of Phosphates and Phosphonates (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Motivations and challenges for high energy petawatt lasers at the National Ignition Facility (2004)

Potential applications of future multi-kilojoule short pulse laser systems and enabling research and development efforts for such lasers at the Lawrence Livermore National Laboratory will be reviewed.