gebhart/patrepeval huggingface dataset:
Reconstituted Discoidal ApoE-Phospholipid Particles Are Ligands for the Scavenger Receptor BI (2002)

The high density lipoprotein receptor, scavenger receptor class B type I (SR-BI), recognizes lipid-bound apolipoprotein A-I (apoA-I) and other apolipoproteins. Here, we have used large scale cultures of apoE-expressing cells to purify apoE and prepare apoE containing reconstituted discoidal 1-palmitoyl-2-oleoyl-l-phosphatidylcholine (POPC)-apoE particles. These particles have been used to examine their binding to wild-type and mutant forms of SR-BI expressed in transfected ldlA-7 cells. Specific binding to SR-BI was determined by subtracting from the total binding, nonspecific values measured using either control untransfected ldlA-7 cells or by inhibiting SR-BI-mediated binding with a high titer antireceptor-blocking antibody. POPC-apoE particles generated using apoE2, apoE3, apoE4, or the carboxyl-terminally truncated forms apoE165, apoE202, apoE229, and apoE259 all bound tightly to wild-type SR-BI with similar affinities (K(d) = 35-45 microg/ml). Binding was nearly abolished in a cell line expressing the ldlA (Q402R/Q418R) double mutant form of SR-BI that is unable to bind native high density lipoprotein but binds low density lipoprotein normally. The findings establish that apoE is a ligand for SR-BI and that the receptor binding domain is located in the amino-terminal 1-165-region of the protein. SR-BI-apoE interactions may contribute to cholesterol homeostasis in tissues and cells expressing SR-BI that are accessible to apoE-containing lipoproteins.
Role of power grid in side channel attack and power-grid-aware secure design (2013)

Side-channel attack (SCA) is a method in which an attacker aims at extracting secret information from crypto chips by analyzing physical parameters (e.g. power). SCA has emerged as a serious threat to many mathematically unbreakable cryptography systems. From an attacker's point of view, the difficulty of mounting SCA largely depends on Signal-to-Noise Ratio (SNR) of the side-channel information. It has been shown that SNR primarily depends on algorithmic and circuit-level implementation, measurement noise, as well as device thermal noise. However, to the best of our knowledge, there has not been any study on the effect of power delivery network (PDN) on SCA resistance. We note that the PDN plays a significant role in SNR of measured supply current. Furthermore, SCA resistance strongly depends on the operating frequency due to RLC structure of a power grid. In this paper, we analyze the effect of power grid on SCA and provide quantitative results to demonstrate the frequency-dependent SCA resistance due to PDN-induced noise. This property can potentially be exploited by an attacker to facilitate the attack by operating a device at favorable frequency points. On the other hand, from a designer's perspective, one can explore countermeasures to secure the device at all operating frequencies while minimizing the design overhead. Based on this observation, we propose a frequency-dependent noise-injection based compensation technique to efficiently protect against SCA. Simulation results using realistic PDN model as well as experimental measurements using FPGA test board validate the observations on role of PDN in SCA and the efficacy of the proposed compensation approach.
Open clinical studies on a new angiotensin II receptor antagonist, TCV 116. (1994)

TCV 116, an angiotensin II receptor antagonist, has potential as an antihypertensive agent. A dose of 4-8 mg once per day appears to be appropriate for the treatment of patients with mild to moderate essential hypertension.
Responding to Intraoperative Neuromonitoring Changes During Pediatric Coronal Spinal Deformity Surgery (2019)

A high incidence of alerts occurred in this series of cases. Dividing IONM changes into perfusion-based vs direct trauma directed treatment to the offending cause, allowing for safe corrections of the deformities. Patients did not need to recover IONM signal to baseline to have a normal neurological examination.
Lithography-free shell-substrate isolation for core–shell GaAs nanowires (2016)

A facile and scalable lithography-free technique(5) for the rapid construction of GaAs core-shell nanowires incorporating shell isolation from the substrate is reported. The process is based on interrupting NW growth and applying a thin spin-on-glass (SOG) layer to the base of the NWs and resuming core-shell NW growth. NW growth occurred in an atmospheric pressure metalorganic vapour phase epitaxy (MOVPE) system with gold nanoparticles used as catalysts for the vapour-liquid-solid growth. It is shown that NW axial core growth and radial shell growth can be resumed after interruption and even exposure to air. The SOG residues and native oxide layer that forms on the NW surface are shown to prevent or perturb resumption of epitaxial NW growth if not removed. Both HF etching and in situ annealing of the air-exposed NWs in the MOVPE were shown to remove the SOG residues and native oxide layer. While both procedures are shown capable of removing the native oxide and enabling resumption of epitaxial NW growth, in situ annealing produced the best results and allowed construction of pristine core-shell NWs. No growth occurred on SOG and it was observed that axial NW growth was more rapid when a SOG layer covered the substrate. The fabricated p-core/n-shell NWs exhibited diode behaviour upon electrical testing. The isolation of the NW shells from the substrate was confirmed by scanning electron microscopy and electrical measurements. The crystal quality of the regrown core-shell NWs was verified with a high resolution transmission electron microscope. The reported technique potentially provides a pathway using MOVPE for scalable and high-throughput production of shell-substrate isolated core-shell NWs on an industrial scale.
Comparison of Solid‐State and Spray‐Pyrolysis Synthesis of Yttrium Aluminate Powders (1997)

The influence of precursor characteristics and synthesis conditions on the formation of yttrium aluminum garnet, Y 3 Al 5 O 12 (YAG), was investigated using “single‐source” precursors (cohydrolyzed yttrium and aluminum alkoxides and yttrium aluminum glycolates) and “multiple‐source” precursors (mixtures of metal nitrates and mixtures of separately hydrolyzed yttrium and aluminum alkoxides). Phase‐pure YAG was formed only in the solid‐state thermal decomposition experiments. The lack of formation of YAG in all the spray‐pyrolysis experiments was ascribed to the short heating times and fast heating rates, which resulted in the formation of kinetic products. In the case of the metal nitrates, an additional factor that influenced product formation was the difference in thermal reactivity of the precursors. It was concluded that the formation of complex metal oxide materials by conventional or aerosol routes is not necessarily achieved by the use of a chemically homogeneous precursor, such as a single‐source precursor. It also was necessary to ensure that the precursors and intermediates have similar thermal decomposition temperatures to avoid phase segregation in the initial stages of thermal decomposition.
Dual-twist fiber long period gratings (2009)

Long period fiber gratings couple core and co-propagating cladding modes to produce dips in the transmission spectrum and have been widely utilized as sensors and filters. We have recently developed a new approach to long period fiber gratings utilizing optical fibers, which are uniformly twisted at elevated temperatures to produce double or single helices. Because these fibers are not manufactured by exposing photosensitive glass to patterned UV illumination, as is the case for traditional fiber Bragg gratings (FBGs) or long period gratings (LPGs), they are more robust in harsh thermal and chemical environments. Double helix fibers are polarization sensitive and are fabricated by twisting fiber preforms with high-index noncircular cores while single helix gratings are polarization insensitive and are created by twisting standard optical fibers with cores that are not perfectly centered. Here, we present a new approach to single-helix chiral long-period gratings (CLPGs). The CLPG is created in a glassforming process in which two optical fibers are twisted together to form a helix in the signal fiber as the fibers pass through a miniature oven. "Dual-twist" CLPGs may be fabricated from any conventional or specialty fiber and provide reproducible spectra that may be tailored to specific applications.
SHIFT-Sliding and DEPTH-POP for 3D Positioning (2016)

Moving objects is an important task in 3D user interfaces. We describe two new techniques for 3D positioning, designed for a mouse, but usable with other input devices. The techniques enable rapid, yet easy-to-use positioning of objects in 3D scenes. With sliding, the object follows the cursor and moves on the surfaces of the scene. Our techniques enable precise positioning of constrained objects. Sliding assumes that by default objects stay in contact with the scene's front surfaces, are always at least partially visible, and do not interpenetrate other objects. With our new Shift-Sliding method the user can override these default assumptions and lift objects into the air or make them collide with other objects. Shift-Sliding uses the local coordinate system of the surface that the object was last in contact with, which is a new form of context-dependent manipulation. We also present Depth-Pop, which maps mouse wheel actions to all object positions along the mouse ray, where the object meets the default assumptions for sliding. For efficiency, both methods use frame buffer techniques. Two user studies show that the new techniques significantly speed up common 3D positioning tasks.
Power Electronic Drives, Controls, and Electric Generators for Large Wind Turbines–An Overview (2015)

Wind represents a major and growing source of renewable energy for the electric power systems. This article provides an overview of state-of-the-art technologies and anticipated developments in the area of power electronic drives, controls, and electric generators for large multi-megawatt wind turbine systems. The principal components employed in a turbine for energy conversion from wind to electricity are described, and the main solutions that are commercially available are briefly reviewed. The specific issues of complex mission profiles, power codes, and reliability are discussed. Topics of power electronics, ranging from devices to circuit topologies, and similar matters for electric generators, together with results of optimal design studies are included. It is shown that the individual power rating of wind turbines has increased over the years, and technologies required to reach and exceed a power rating of 10 MW are discussed. The role of power electronics for improving the operation of wind turbines and ensuring compliance with power grid codes is analyzed with a view at producing fully controllable generation units suitable for tight integration into the power grid and large-scale deployment in future smart power systems.
A Composite Cu/HOPG Heat Spreader for Immersion Cooling of High Power Chips (2015)

Presented are the results of a 3-D numerical analysis of a composite heat spreader for immersion cooling of a 20 × 20 mm microprocessor. The spreader is comprised of two 0.5 mm thick Copper (Cu) laments separated by a layer of highly ordered pyrolytic graphite (HOPG), 0.25–1.0 mm thick. The exposed surface of the top Cu lament has an average roughness, Ra = 1.79 μm and is cooled by saturation nucleate pool boiling of PF-5060 dielectric liquid. Investigate is the impact of δHOPG on the total power removed, the maximum temperature of the underlying chip, Tmax, and mitigating the chip hot spots. Increasing δHOPG increases the total power removed, but also increases Tmax. The spreader with a 1.0 mm-thick δHOPG is capable of removing 318 W, without exceeding 90% of the critical heat flux (CHF), at Tmax = 120°C. This power removal is significantly higher than that with an all Cu spreader of the same thickness of 90 W, but at much lower Tmax of 67°C. Composite spreaders with δHOPG = 0.25, 0.5, and 0.75 mm are capable of removing up to 160 W at Tmax = 85°C, 228 W at 100°C, and 292W at 115°C, respectively. The HOPG suppresses the transmission of hot spots to the spreader surface and increasing δHOPG does not mitigate the hot spots.
A semiconductor memory development and manufacturing perspective (2014)

Semiconductor memories are growing in importance as they are now fundamental in every electronic system and offer new manufacturing and development challenges and opportunities. From a manufacturing point of view, the industry has undergone consolidation and today very few players are able to supply the high wafer volumes required by the global market. From a technology development point of view, new applications requiring lower power, higher memory density and improved performance creates opportunities for alternative memory technologies. Moreover, the shift to 3-dimensional integration and to new system architectures result in both manufacturing and technology challenges.
Simulation of the post-implantation anneal for emitter profile optimization in high efficiency c-Si solar cells (2012)

The use of ion implantation to form local doping profiles in solar cells has regained interest, as it simplifies the manufacturing process, is litho-free, and high efficiency levels can be obtained [1]. However, residual damage after post annealing can lead to increased saturation current values (J0e), so optimization of the annealing process is required. A full simulation of the anneal treatment and its impact on profile and oxide formation was developed, based on the Synopsys Process TCAD software, for the boron doping case. The validity of the models and parameter set was experimentally verified through SIMS (Secondary Ion Mass Spectroscopy) profiles, sheet resistance and ellipsometry measurements.
Application of adaptive optics in retinal imaging: a quantitative and clinical comparison with standard cameras (2005)

Aim: The objective of this project was to evaluate high resolution images from an adaptive optics retinal imager through comparisons with standard film-based and standard digital fundus imagers. Methods: A clinical prototype adaptive optics fundus imager (AOFI) was used to collect retinal images from subjects with various forms of retinopathy to determine whether improved visibility into the disease could be provided to the clinician. The AOFI achieves low-order correction of aberrations through a closed-loop wavefront sensor and an adaptive optics system. The remaining high-order aberrations are removed by direct deconvolution using the point spread function (PSF) or by blind deconvolution when the PSF is not available. An ophthalmologist compared the AOFI images with standard fundus images and provided a clinical evaluation of all the modalities and processing techniques. All images were also analyzed using a quantitative image quality index. Results: This system has been tested on three human subjects (one normal and two with retinopathy). In the diabetic patient vascular abnormalities were detected with the AOFI that cannot be resolved with the standard fundus camera. Very small features, such as the fine vascular structures on the optic disc and the individual nerve fiber bundles are easily resolved by the AOFI. Conclusion: This project demonstrated that adaptive optic images have great potential in providing clinically significant detail of anatomical and pathological structures to the ophthalmologist.
Integration of Leakage Inductance in Tape Wound Core Transformers for Dual Active Bridge Converters (2012)

Dual Active Bridge (DAB) converters are nowadays used in applications such as automotive and general energy storage interfaces, where efficient and compact isolated bidirectional DC/DC converters are required. The heart of this converter is a transformer which, in some designs, may include the required inductance to shape the current and control the energy transfer. This paper shows that for these designs, tape wound cores, usually made of amorphous or nanocrystalline materials, are not the best core option due to leakage flux which is orthogonal to the lamination layers. This flux increases losses in these types of cores. Solutions are proposed to overcome this significant drawback. Analysis developed in this paper is validated by experimental results, which show that core losses due to orthogonal flux in a tape wound core transformer can be reduced more than 6 times if an adapted leakage layer is used instead of a regular one.
TargetRNA2: identifying targets of small regulatory RNAs in bacteria (2014)

Many small, noncoding RNAs (sRNAs) in bacteria act as posttranscriptional regulators of messenger RNAs. TargetRNA2 is a web server that identifies mRNA targets of sRNA regulatory action in bacteria. As input, TargetRNA2 takes the sequence of an sRNA and the name of a sequenced bacterial replicon. When searching for targets of RNA regulation, TargetRNA2 uses a variety of features, including conservation of the sRNA in other bacteria, the secondary structure of the sRNA, the secondary structure of each candidate mRNA target and the hybridization energy between the sRNA and each candidate mRNA target. TargetRNA2 outputs a ranked list of likely regulatory targets for the input sRNA. When evaluated on a comprehensive set of sRNA-target interactions, TargetRNA2 was found to be both accurate and efficient in identifying targets of sRNA regulatory action. Furthermore, TargetRNA2 has the ability to integrate RNA-seq data, if available. If an sRNA is differentially expressed in two or more RNA-seq experiments, TargetRNA2 considers co-differential gene expression when searching for regulatory targets, significantly improving the accuracy of target identifications. The TargetRNA2 web server is freely available for use at http://cs.wellesley.edu/∼btjaden/TargetRNA2.
Downstream Processing, Formulation Development and Antithrombotic Evaluation of Microbial Nattokinase (2014)

The present research work describes the downstreaming of nattokinase (NK) produced by Bacillus subtilis under solid state fermentation; and the role of efficient oral formulation of purified NK in the management of thrombotic disorders. Molecular weight of purified NK was estimated to be 28 kDa with specific activity of 504.4 FU/mg. Acid stable nattokinase loaded chitosan nanoparticles (sNLCN) were fabricated for oral delivery of this enzyme. Box-Behnken design (BBD) was employed to investigate and validate the effect of process (independent) variables on the quality attributes (dependent variables) of nanoparticles. The integrity, conformational stability and preservation of fibrinolytic activity of NK (in both free and sNLCN forms) were established by SDS-PAGE, CD analysis and in vitro clot lytic examination, respectively. A 'tail thrombosis model' demonstrated significant decrease in frequency of thrombosis in Wistar rats upon peroral administration of sNLCN in comparison with negative control and free NK group. Furthermore, coagulation analysis, namely the measurement of prothrombin and activated partial thromboplastin time illustrated that sNLCN showed significantly (p < 0.001) higher anti-thrombotic potential in comparison to the free NK. Further, sNLCN showed anti-thrombotic profile similar to warfarin. This study signifies the potential of sNLCN in oral delivery of NK for the management of thrombotic disorders.
Visible-Light-Driven Photoreactions of [(bpy)2Ru(II)L]Cl2 in Aqueous Solutions (bpy = Bipyridine, L = 1,2-Bis(4-(4‘-methyl)-2,2‘-bipyridyl) Ethene) (2008)

Visible-light-induced photoreactions of [(bpy)2Ru(II)L]Cl2 (bpy = bipyridine, L = trans-1,2-bis(4-(4'-methyl)-2,2'-bipyridyl) ethene) in aqueous solution are examined. From pH titrations, it is found that the Ru complex is a stronger base (pKa* = 6) in the excited state than in the ground state (pKa = 4). Photolysis of the [(bpy)2Ru(II)L] complex in solutions at pH 7 and 12 led to formation of species with increased emission quantum yields, approximately 55 nm blue-shift of the emission maximum to 625 nm, and disappearance of the absorption band at 330 nm, the latter arising from the olefinic bond of the L ligand. No spectral changes are observed in solutions at pH < or = 4. With the help of chromatography, mass spectroscopy, Raman spectroscopy, and NMR, photoproducts formed at neutral pH have been analyzed. It is found that the major product is a dimer of [(bpy)2Ru(II)L], dimerizing around the double bond. Photoreactions do not occur in the dark or in the aprotic solvent acetonitrile. We propose that a Ru(III) radical intermediate is formed by photoinduced excited-state electron and proton transfer, which initiates the dimerization. The radical intermediate can also undergo photochemical degradative reductions. Below pH 4, the emission quenching is proposed to arise via protonation of the monoprotonated [(bpy)2Ru(II)LH] followed by electron transfer to the viologen-type moiety created by protonation. The products of photodegradation at pH > 12 are different from those of pH 7, but the mechanism of the degradation at pH > 12 was not elucidated.
A Nonsupervised Learning Approach for Automatic Characterization of Short-Distance Boxing Training (2023)

Human activity recognition (HAR) for boxing training typically requires specialized hardware or large labeled datasets to identify different types of punches and analyze their basic properties. However, measuring the unpredictability of boxers, a key characteristic to deceive opponents during combats, has remained an unexplored challenge. We tackled this challenge by combining a series of novel techniques and ideas. Unpredictability was computed as the entropy of the trajectories of the Markov chain characterizing the training session, estimated from the combinations (sequences of punches) thrown by the boxer to the training bag. Punch combinations were obtained by detecting punches as outliers in the raw acceleration sensor datastream coming from the bag, and separating them by type with an ensemble of PCA+GMM clusters. Punches were then divided into combinations using statistical analysis of separation intervals. The detection procedure works even with noisy data, in contrast to force-threshold methods commonly reported in the literature. As distinctive features of our system, it uses only unlabeled data from the current training session, and sensor positions and orientations inside the bag are unconstrained. However, punch clustering achieves up to 94% accuracy, comparable to state-of-the-art supervised approaches. These features are currently unseen in the literature and demonstrate the capacity for unsupervised learning techniques to address challenging problems in sports. Multiple validation experiments were consistent with boxers’ level and session performance. Overall, our approach provides significant contributions to the field of HAR and has the potential to improve the way boxing and other sports are trained and evaluated.