gebhart/patrepeval huggingface dataset:
An HLA-Presented Fragment of Macrophage Migration Inhibitory Factor Is a Therapeutic Target for Invasive Breast Cancer (2011)

This report describes a novel HLA/peptide complex with potential prognostic and therapeutic roles for invasive breast cancer. Macrophage migration inhibitory factor (MIF) mediates inflammation and immunity, and MIF overexpression is observed in breast cancer. We hypothesized that the HLA class I of cancerous breast epithelial cells would present MIF-derived peptides. Consistent with this hypothesis, the peptide FLSELTQQL (MIF(19-27)) was eluted from the HLA-A*0201 (HLA-A2) of breast cancer cell lines. We posited that if this MIF(19-27)/HLA-A2 complex was exclusively found in invasive breast cancer, it could be a useful prognostic indicator. To assess the presentation of MIF peptides by the HLA of various cells and tissues, mice were immunized with the MIF(19-27)/HLA-A2 complex. The resulting mAb (RL21A) stained invasive ductal carcinoma (IDC) but not ductal carcinoma in situ, fibroadenoma, or normal breast tissues. RL21A did not stain WBCs (total WBCs) or normal tissues from deceased HLA-A2 donors, substantiating the tumor-specific nature of this MIF/HLA complex. As this MIF/HLA complex appeared specific to the surface of IDC, RL21A was tested as an immunotherapeutic for breast cancer in vitro and in vivo. In vitro, RL21A killed the MDA-MB-231 cell line via complement and induction of apoptosis. In an in vivo orthotopic mouse model, administration of RL21A reduced MDA-MB-231 and BT-20 tumor burden by 5-fold and by >2-fold, respectively. In summary, HLA-presented MIF peptides show promise as prognostic cell surface indicators for IDC and as targets for immunotherapeutic intervention.
ChemInform Abstract: 4,10‐Dihydro‐4‐oxo‐4H‐imidazo[1,2‐a]indeno[1,2‐e]pyrazin‐2‐carboxylic Acid Derivatives: Highly Potent and Selective AMPA Receptors Antagonists with in vivo Activity. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Osmotic deswelling of gels by polymer solutions (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOsmotic deswelling of gels by polymer solutionsJ. Bastide, S. Candau, and L. LeiblerCite this: Macromolecules 1981, 14, 3, 719–726Publication Date (Print):May 1, 1981Publication History Published online1 May 2002Published inissue 1 May 1981https://pubs.acs.org/doi/10.1021/ma50004a050https://doi.org/10.1021/ma50004a050research-articleACS PublicationsRequest reuse permissionsArticle Views601Altmetric-Citations111LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Virtual Environment for the Simulation and Programming of Excavation Trajectories (2001)

An excavator simulator has been developed to facilitate the training of human operators and to evaluate control strategies for heavy-duty hydraulic machines. The operator controls a virtual excavator by means of a joystick while experiencing visual and force feedback generated by environment and machine models. The simulator comprises an impedance model of the excavator arm, a model for the bucket-ground interaction forces, a graphically rendered visual environment, and a haptic interface. This paper describes the simulator components and their integration.
Abstract 3820: Ultrasensitive DNA methylation detection using sputum and plasma for early detection of NSCLC (2015)

Abstract Purpose: The National Lung Cancer Screening Trial provides hope that early detection can result in a reduction of mortality from lung cancer. This study was to determine if molecular alterations of sputum and plasma in patients with CT detected pulmonary nodules could predict patients with malignancy from those without. Materials and Methods: We conducted a prospective case-control study obtaining cases and controls from the Lung Cancer Spore Trial at Johns Hopkins Hospital. Plasma, sputum and pre-operative CT scans were obtained from all patients. We processed the plasma, sputum and tumor by using promoter Methylation on beads followed by quantitative methylation specific real-time PCR to investigate promoter methylation status of six cancer-related genes, CDO1, TAC1, HOXA7, HOXA9, SOX17 and ZFP42. Results: 223 patients were analyzed, including 162 patients with NSCLC and 61 patients with benign lesions. The sensitivity and specificity values for lung cancer detection in plasma, sputum or in both are shown. Plasma methylation seems to be more specific than sputum methylation. Both concomitant methylation in both plasma and sputum yielded the highest specificity for all gene combinations. Promoter methylation of CDO1, TAC1, HOXA9 and SOX17 has a high specificity but low sensitivity to detect lung cancer. Sensitivity and specificity for lung cancer detection using methylation changes in plasma and sputumPlasmaPlasmaSputumSputumPlasma &amp; SputumPlasma &amp; SputumGeneSpecificitySensitivitySpecificitySensitivitySpecificitySensitivityCDO180%45%67%63%93%26%TAC167%52%40%65%80%31%HOXA7100%11%80%27%100%6%HOXA960%66%7%90%67%60%SOX1767%56%73%52%93%27%ZFP4247%69%33%74%60%52%4 or more genes67%50%67%63%97%26%CDO1, TAC1, HOXA9, SOX1787%39%80%40%93%15% Conclusion: Our gene panel of promoter methylation has a high enough specificity to be clinical useful but its sensitivity is low. The integration of this panel with other biomarkers would be needed to create a platform of high enough specificity and sensitivity to be clinically applicable. Citation Format: Chen Chen, Alicia Hulbert, Alejandro Stark, Kristen Rodgers, Beverly Lee, Malcolm Brock, James Herman. Ultrasensitive DNA methylation detection using sputum and plasma for early detection of NSCLC. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3820. doi:10.1158/1538-7445.AM2015-3820
Topographically Flat, Chemically Patterned PDMS Stamps Made by Dip‐Pen Nanolithography (2008)

DPN nützt μCP: Die spezifischen Nachteile konventioneller Mikrokontaktdruckverfahren – Stempeleinbruch und laterale Tintendiffusion – lassen sich durch die Verwendung von topographisch flachen, chemisch gemusterten PDMS-Stempeln umgehen. Die durch Dip-Pen-Nanolithographie (DPN) gefertigten Stempel wurden zum Kontaktdrucken verschiedener Tinten, einschließlich Thiolen, Proteinen und hydrophilen Farbstoffen, genutzt. Die frisch erzeugten Muster können Auflösungen unter 100 nm und einen sehr niedrigen Füllfaktor erreichen (siehe AFM-Bild). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Tracking Darkports for Network Defense (2007)

We exploit for defensive purposes the concept of darkports ­ the unused ports on active systems. We are particularly in- terested in such ports which transition to become active (i.e. become trans-darkports). Darkports are identified by pas- sively observing and characterizing the connectivity behav- ior of internal hosts in a network as they respond to both le- gitimate connection attempts and scanning attempts. Dark- ports can be used to detect sophisticated scanning activity, enable fine-grained automated defense against automated malware attacks, and detect real-time changes in a network that may indicate a successful compromise. We show, in a direct comparison with Snort, that darkports offer a better scanning detection capability with fewer false positives and negatives. Our results also show that the network awareness gained by the use of darkports enables active response op- tions to be safely focused exclusively on those systems that directly threaten the network.
Towards a social fabric for pervasive assistive environments (2009)

The digital divide refers to a lack of technological access, part of which involves exclusion from a blooming arena of social interaction. People without mobile phones or PCs cannot access email, SMS or social networking websites; this includes many groups, such as the elderly, who can become vulnerable without good social contact. By enabling multimodal access to a variety of communication channels, including ubiquitous ones such as televisions and home telephones, this set of people can be included in such interactions. This paper describes a prototype pervasive messaging infrastructure for multimodal communications, and how it can be used as an assistive environment. Our eventual aim is to create a social fabric, a pervasive infrastructure layer to support more complex social experiences in the future.
SGLT‐2 Inhibitors in Heart Failure: Current Management, Unmet Needs, and Therapeutic Prospects (2019)

10.1161/JAHA.119.013389
ICAM-1–targeted thrombomodulin mitigates tissue factor–driven inflammatory thrombosis in a human endothelialized microfluidic model (2017)

Diverse human illnesses are characterized by loss or inactivation of endothelial thrombomodulin (TM), predisposing to microvascular inflammation, activation of coagulation, and tissue ischemia. Single-chain antibody fragment (scFv)/TM) fusion proteins, previously protective against end-organ injury in murine models of inflammation, are attractive candidates to treat inflammatory thrombosis. However, animal models have inherent differences in TM and coagulation biology, are limited in their ability to resolve and control endothelial biology, and do not allow in-depth testing of "humanized" scFv/TM fusion proteins, which are necessary for translation to the clinical domain. To address these challenges, we developed a human whole-blood, microfluidic model of inflammatory, tissue factor (TF)-driven coagulation that features a multichannel format for head-to-head comparison of therapeutic approaches. In this model, fibrin deposition, leukocyte adhesion, and platelet adhesion and aggregation showed a dose-dependent response to tumor necrosis factor-α activation and could be quantified via real-time microscopy. We used this model to compare hTM/R6.5, a humanized, intracellular adhesion molecule 1 (ICAM-1)-targeted scFv/TM biotherapeutic, to untargeted antithrombotic agents, including soluble human TM (shTM), anti-TF antibodies, and hirudin. The targeted hTM/R6.5 more effectively inhibited TF-driven coagulation in a protein C (PC)-dependent manner and demonstrated synergy with supplemental PC. These results support the translational prospects of ICAM-targeted scFv/TM and illustrate the utility of the microfluidic system as a platform to study humanized therapeutics at the interface of endothelium and whole blood under flow.
Revised Definitions of Invasive Fungal Disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group (2008)

These revised definitions of invasive fungal disease are intended to advance clinical and epidemiological research and may serve as a useful model for defining other infections in high-risk patients.
Identification of cardiovascular dynamics from peripheral circulatory waveform signals using two sensor blind system I.D (2005)

A new tool for characterizing systemic and local hemodynamic behavior in real-time has been developed. Through the evaluation of two peripheral circulatory waveform measurements (e.g. continuous measurements such as pressure or flow or volumetric change) this new signal-processing algorithm generates two compact, low order models that describe the distinct branch dependent features of the measured circulatory signals. The method employs a multichannel blind system identification (MBSI) technique that has been reformulated to use a Laguerre basis series expansion. The new MBSI approach allows accurate identification of vascular hemodynamics in experimental data measured in a swine model.
DNA unzipping phase diagram calculated via replica theory (2009)

We show how single-molecule unzipping experiments can provide strong evidence that the zero-force melting transition of long molecules of natural dsDNA should be classified as a phase transition of the higher-order type (continuous). Toward this end, we study a statistical-mechanics model for the fluctuating structure of a long molecule of dsDNA, and compute the equilibrium phase diagram for the experiment in which the molecule is unzipped under applied force. We consider a perfect-matching dsDNA model, in which the loops are volume-excluding chains with arbitrary loop exponent c . We include stacking interactions, hydrogen bonds, and main-chain entropy. We include sequence heterogeneity at the level of random sequences; in particular, there is no correlation in the base-pairing (bp) energy from one sequence position to the next. We present heuristic arguments to demonstrate that the low-temperature macrostate does not exhibit degenerate ergodicity breaking. We use this claim to understand the results of our replica-theoretic calculation of the equilibrium properties of the system. As a function of temperature, we obtain the minimal force at which the molecule separates completely. This critical-force curve is a line in the temperature-force phase diagram that marks the regions where the molecule exists primarily as a double helix versus the region where the molecule exists as two separate strands. We compare our random-sequence model to magnetic tweezer experiments performed on the 48 502 bp genome of bacteriophage lambda . We find good agreement with the experimental data, which is restricted to temperatures between 24 and 50 degrees C . At higher temperatures, the critical-force curve of our random-sequence model is very different for that of the homogeneous-sequence version of our model. For both sequence models, the critical force falls to zero at the melting temperature T_{c} like |T-T_{c}|;{alpha} . For the homogeneous-sequence model, alpha=1/2 almost exactly, while for the random-sequence model, alpha approximately 0.9 . Importantly, the shape of the critical-force curve is connected, via our theory, to the manner in which the helix fraction falls to zero at T_{c} . The helix fraction is the property that is used to classify the melting transition as a type of phase transition. In our calculation, the shape of the critical-force curve holds strong evidence that the zero-force melting transition of long natural dsDNA should be classified as a higher-order (continuous) phase transition. Specifically, the order is 3rd or greater.
One Component Membrane Reactor for Partial Oxidation of Methane Using Asymmetric Membranes (2009)

Abstract Oxygen permeable asymmetric membranes of Ca0.8Sr0.2Ti0.7Fe0.3O3−δ were applied to a one-component membrane reactor (OCMR) for the partial oxidation of methane. CH4 conversion and oxygen flux of OCMR with a 43-μm dense layer at 1173 K reached 71% and 1.7 mL min−1 cm−2, respectively. These values are 2.5 times greater than that of a 500-μm self-supported membrane.
ChemInform Abstract: Haliclamide, a Novel Cyclic Metabolite from the Vanuatu Marine Sponge Haliclona sp. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An Eight-Core RISC-V Processor With Compute Near Last Level Cache in Intel 4 CMOS (2022)

An eight-core 64-b processor extends RISC-V to perform multiply–accumulate (MAC) within the shared last level cache (LLC). Instead of moving data from the LLC to the core, compute near last level cache (CNC) adds MAC to the LLC datapath and performs computation near where the data are stored. The RV64GC CNC instruction set architecture (ISA) extension performs digital MAC near unmodified SRAM arrays and has a low area overhead of 1.4%. CNC increases memory access width to 512 b per instruction by avoiding bottlenecks in the on- chip networks. The operation also reduces data movement by keeping MAC results and most input operands local to the LLC slices. CNC supports computation on cached data from main memory, coherent data sharing between cores, and virtual addressing. The CNC instructions are included in C++ programs and run either baremetal or in Linux. The 1.15-GHz chip reduces energy consumption by 52 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\times $ </tex-math></inline-formula> for fully connected and 29 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\times $ </tex-math></inline-formula> for convolutional deep neural network (DNN) layers, compared to scalar operation. Two benchmarks are characterized: MLPerf Tiny Anomaly Detection v0.5 latency is reduced by 4.25 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\times $ </tex-math></inline-formula> to 40 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mu \text{s}$ </tex-math></inline-formula> versus previous work, and inference latency on memory-augmented neural networks is improved by 4.1 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\times $ </tex-math></inline-formula> versus scalar operation.
Simulación del procesamiento de una aleación de Ti-6Al-7Nb por la técnica de presión en canal angular constante usando el método de elementos finitos (2017)

En este trabajo se utilizó el método de elementos finitos para el análisis de la deformación plástica de una barra de Ti-6Al-7Nb de sección cuadrada con dimensiones de 10 x 10 mm2, procesada mediante la técnica de presión en canal angular constante (ECAP, por sus siglas en inglés). Primeramente, se simuló el procesamiento con diferentes ángulos internos y radios de curvatura externo e interno del canal, por medio de un modelo simplificado en 2D. Se determinó la influencia de estos parámetros en la magnitud y la homogeneidad de la deformación, así como de la carga aplicada. A partir de los resultados de la simulación en 2D, se seleccionaron los radios de curvatura óptimos para cada ángulo interno, a partir de un diseño propuesto para las dimensiones externas y el material del dado de procesamiento de ECAP. Seguidamente, mediante la simulación en 3D se determinó que tanto las dimensiones y el material del dado seleccionados, son adecuados para resistir las altas presiones del proceso.&lt;br /&gt;&lt;br /&gt;
Open-Label Study to Evaluate the Safety & Tolerability of Telaprevir in Combination With Sofosbuvir in Naive Subjects Infected With Hepatitis C Virus Genotype 1 (2015)

Background &amp; Aims : Sofosbuvir is a potent hepatitis C NS5B polymerase inhibitor that has led to high-sustained viral response rates when combined with other direct-acting antivirals. To date, no data exists on the combination of sofosbuvir with the NS3 protease inhibitor, telaprevir. The safety, tolerability, and efficacy of an all-oral 12-week regimen of telaprevir in combination with sofosbuvir were evaluated in this open-label, phase 2 study. Methods: Twenty adults with genotype 1 hepatitis C infection who were non-cirrhotic and naïve to therapy received telaprevir 1125 mg orally twice-daily plus sofosbuvir 400 mg once daily for 12 weeks. Results : Telaprevir plus sofosbuvir was generally well tolerated, with all 20 subjects completing treatment. The five most common adverse events were nausea, rash, headache, ano-rectal symptoms, and pruritus. Two subjects required discontinuation of telaprevir after week 4 but were maintained on sofosbuvir till the end of treatment. Sustained virologic response 12 weeks after the end of treatment was 95%. Conclusion : The results provide valuable information regarding the safety, tolerability and efficacy of telaprevir combined with sofosbuvir as dual therapy in naïve non-cirrhotic genotype 1 patients.
CLINICAL USEFULNESS AND LIMITATION OF BRACHIAL-ANKLE PULSE WAVE VELOCITY TO EVALUATE CARDIOVASCULAR COMPLICATIONS IN PATIENTS WITH ESSENTIAL HYPERTENSION (2004)

Ito, N; Ohishi, M; Kaibe, M; Takagi, T; Katsuya, T; Rakugi, H; Ogihara, T Author Information
A document layout system using automatic document architecture extraction (1989)

A document layout system based on automatic extraction of document architecture including logical and reference structures has been developed for reducing users' effort in document preparation, and has been implemented in a practical Japanese word processor. The extracted document architecture is used for both automatic text formatting and layout of text, figures and tables. Automatic text element recognition is performed by morphological analysis using keywords. Through intra-line (one sentence) and inter-line (relations between sentences) analysis, logical and reference structures are obtained. The automatic layout system effectively lays out the document using the extracted document architecture and knowledge about the layout.
Experimental evidence for a dual vacancy–interstitial mechanism of self-diffusion in silicon (1998)

Epitaxially grown isotopically enriched Si layers have been used to study self-diffusion in Si directly at the temperatures of 1000 and 1100 °C. We obtain equilibrium diffusion coefficients in accordance with previous experiments and theoretical calculations. Comparison of diffusion data of self-, antimony, and phosphorus diffusion in Si under identical conditions of perturbed self-interstitial and vacancy concentrations created by surface reactions enables us to determine the microscopic mechanisms of Si self-diffusion. We find that, in this temperature range, self-interstitials contribute roughly 2/3 to Si self-diffusion, and vacancies 1/3, with the concerted exchange component being less than 14%. This constitutes direct experimental evidence that, on the atomic scale, self-diffusion in Si is mediated both by self-interstitials and vacancies.