gebhart/patrepeval huggingface dataset:
Synthesis of 4-(Phenylamino)quinoline-3-carboxamides as a Novel Class of Gastric H+/K+-ATPase Inhibitors. (1995)

In search for inhibitors of gastric H+/K+-ATPase, 4-(phenylamino)quinoline-3-carboxamides were synthesized and evaluated for antisecretory activity against histamine-induced gastric acid secretion in rats. These compounds were synthesized by condensation of aniline derivatives with N-substituted 4-chloroquinoline-3-carboxamides, which were obtained from treatment of 4(1H)-quinolinone-3-carboxylic acid with thionyl chloride. Most of the compounds inhibited histamine-induced gastric acid secretion in rats. Among them, N-allyl-4-(2-ethylphenylamino)quinoline-3-carboxamide (4h) was the most potent inhibitor and had the best profile as a candidate antiulcer agent. This compound showed reversible, K+-competitive gastric H+/K+-ATPase inhibitory activity.
ChemInform Abstract: PHENYLMETHYLPOLYSILANES: FORMABLE SILANE COPOLYMERS WITH POTENTIAL SEMICONDUCTING PROPERTIES (1982)

Abstract Die Cokondensation von Dimethyl‐ und Phenylmethylsilyldichlorid in Toluol in Gegenwart von Na (90‐100°C) führt zu amorphen linearen Polymeren [(PhMeSi)(Me 2 Si) x ] y , deren Hauptanteil eine Zusammensetzung von PhMeSi/Me 2 Si von 1 hat, d.h. x = 1. Fraktionen mit dem höchsten Molgewicht sind phenylreicher (x bis zu 0.6).
Fluid Management in the Intensive Care Unit: Bioelectrical Impedance Vector Analysis as a Tool to Assess Hydration Status and Optimal Fluid Balance in Critically Ill Patients (2013)

(i) On the day of ICU admittance, patients showed a marked tendency to overhydration (>70% of total). This tendency was more pronounced in patients on CRRT. (ii) Hyperhydration persisted during the ICU stay. Patients who underwent CRRT showed significantly higher hyperhydration from the 2nd day of hospitalization. (iii) Nonsurvivors showed worse hyperhydration patterns in comparison to survivors in logistic univariate analysis (p < 0.05). This relationship between hydration and mortality is confirmed even when controlling for the effect of a worse prognosis approximated by any of three ICU scoring systems (APACHE II, SAPS II and SOFA). Mean and maximum hydration levels present a stronger correlation with mortality than with mean and maximum cumulative fluid balance reached during the observation period.
Investigation of Different Phenolic Resins and their Behavior during Pyrolysis to Form SiC/C-Composites (2015)

Specific phenolic resin samples have been developed as the carbon precursor for SiC/C composites. Liquid phenolic resins suitable for fiber-infiltration in the resin transfer moulding (RTM) process are synthesized by using versatile combination of the aromatic component (phenol, naphthalen-2-ol) with various formaldehyde equivalents such as methanal, 1,3,5,7tetraazatricyclo [3.3.1.1 3,7 ] decane (urotropine), and 1,3,5-trioxane, under different reaction conditions. Room temperature liquid resoles (RTLR) are obtained by using an excess of the formaldehyde component over phenol (≥2) under basic conditions. Upon heating RTLR can form a crosslinked network even without addition of a hardening reagent. In addition, novolacs are synthesized under acidic conditions using a phenol/formaldehyde ratio ≥1. Nitrogen-containing resins contain nitrogen due to reaction of phenol with urotropine. Novolacs and nitrogen-containing resins are solids at room temperature and not self-curing. To infiltrate these both resins into SiC fibers in the RTM process, they are dissolved in 2furanmethanol (furfuryl alcohol FA) and urotropine which is added as curing-agent. Both, the molecular weight and the amount of the dissolved phenolic resin have an influence on the viscosity and the carbon yield after pyrolysis which is important for this application. The aim was to create different phenolic resins for the fabrication in the RTM process and to characterize the carbon after pyrolysis with respect to the structure and porosity as these are key parameters to generate a stoichiometric SiC matrix by LSI.
Kingdon Trap (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Dual-functional diffraction grating based on selective metal deposition of photochromic diarylethene (2011)

Dual-functional diffraction gratings, which show different diffractions in transmission and reflection, are proposed as an essential optical element. We utilize a flattening effect of photochromic diarylethene (DAE) in the low glass transition temperature state and selective metal deposition to prepare the gratings. The uncolored lines of the colored DAE layer on a grating substrate with grooves were formed by red-laser scanning, and Mg evaporation onto the substrate without a shadow mask enabled Mg-line formation at right angles to the grooves. After being stored at 27 °C for 500 min, the sample showed two-dimensional diffraction in reflection but one-dimensional diffraction in transmission, meaning that a dual-functional grating was achieved. This result shows great potential as a key element for various future optical devices and systems.
High pressure microwave flow reactor for raw oil treatment (2016)

A high pressure short time heat treatment is required for improvement of fluid properties of viscous raw oil and reduction of energy consumption for pumping. Microwave heating is investigated to achieve significant process improvements as compared to conventional heating technology. The engineering of a lab-scale flow reactor is presented that allows continuous microwave treatment for a maximum flow rate of 11 kg/h at 300 to 400 °C and up to 30 bar pressure. A unique microwave cavity design has been developed to enable homogeneous temperature distribution, high energy efficiency, and safe operation at high pressure.
Mixed Diketonate Thiolate Copper(I) Precursors for Materials Synthesis: Control of Cu2S‐Forming Thermolysis Pathways by Manipulating Lewis Acid and Base Cluster Building Blocks (2006)

Scission precision: The combination of Lewis acidic and Lewis basic building blocks in copper(I) thiolate clusters enables control of the thermal decomposition pathway in the design of new molecular precursors for Cu2S formation. After CS bond scission, large clusters with cuprous sulfide cores are isolated as intermediates and are structurally characterized (see scheme; hfa=hexafluoroacetylacetonate). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z503691_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Fatal vocal cord granuloma after orthognathic surgery (2018)

Endotracheal intubation is commonly associated with laryngeal injury that often resolves spontaneously without any complication. However, stenosis or granulomatous lesions are generally found on the tracheal wall or vocal process at the tube cuff level, caused by excessive cuff pressure. We present a case of fatal vocal cord granuloma leading to dyspnea following orthognathic surgery and sustained intubation for 14 hours.
First clinical use of novel ablation catheter incorporating local impedance data (2018)

This novel catheter gives reproducible recordings of local impedance, which are dependent on scar level. Absolute LI drop, and also percentage drop, on ablation may give an indication of tissue contact and subsequent effective lesion formation.
Shedding Light on Enterprise Network Failures Using Spotlight (2010)

Fault localization in enterprise networks is extremely challenging. A recent approach called Sherlock makes some headway into this problem by using an inference algorithm over a multi-tier probabilistic dependency graph that relates fault symptoms with possible root causes (e.g., routers, servers). A key limitation of Sherlock is its scalability because of the use of complicated inference algorithms based on Bayesian networks. We present a fault localization system called Spotlight that essentially uses two basic ideas. First, it compresses a multi-tier dependency graph into a bipartite graph with direct probabilistic edges between root causes and symptoms. Second, it runs a novel weighted greedy minimum set cover algorithm to provide fast inference. Through extensive simulations with real service dependency graphs and enterprise network topologies reported previously in literature, we show that Spotlight is about 100× faster than Sherlock in typical settings, with comparable accuracy in diagnosis.
Exact Hamiltonian Monte Carlo for Truncated Multivariate Gaussians (2012)

We present a Hamiltonian Monte Carlo algorithm to sample from multivariate Gaussian distributions in which the target space is constrained by linear and quadratic inequalities or products thereof. The Hamiltonian equations of motion can be integrated exactly and there are no parameters to tune. The algorithm mixes faster and is more efficient than Gibbs sampling. The runtime depends on the number and shape of the constraints but the algorithm is highly parallelizable. In many cases, we can exploit special structure in the covariance matrices of the untruncated Gaussian to further speed up the runtime. A simple extension of the algorithm permits sampling from distributions whose log-density is piecewise quadratic, as in the "Bayesian Lasso" model.
Detection of minimal residual disease (MRD) in colorectal cancer (CRC) patients UICC stage II/III by ultra-deep sequencing of cfDNA from post-surgery plasma. (2022)

26 Background: Detection of primary tumor mutations in cell-free DNA (cfDNA) of post-surgery plasma of patients with R0-resected not-metastasized solid tumors is a strong indicator of recurrence of disease. We explored whether ultra-deep sequencing of cfDNA could improve sensitivity and specificity with respect to time-to-progression. Methods: 84 CRC patients UICC stage II/III were recruited into the prospective, observational study “Molecular Signatures in Colorectal Cancer”. Matched tumor tissue samples, plasma depleted blood cells (PDBC), and cfDNA (drawn 1 to 34 days after R0-resection, median 7 days) were processed with the Roche AVENIO Tumor Tissue and ctDNA Surveillance Kits*. Samples of 79 patients passed all quality controls, in particular cfDNA was sequenced ultra-deep with a median of 180 Mio. instead of 50 Mio. reads/sample. Somatic variants were identified with AVENIO Oncology Analysis software 2.0*. PDBC informed germline variants were removed. If a tissue baseline variant was detected in cfDNA with a significant adjusted p-value, the patient was defined ctDNA+, and ctDNA- otherwise. Results: 8 ctDNA+ patients (28 variants, median AF = 0.15%) were identified of which 4 had a progression of disease at two years. Sensitivity was 44% (95% CI [0.137, 0.788]), specificity was 94% (95% CI [0.86, 0.984]), positive predictive value was 50% (95% CI [0.157, 0.843]), and negative predictive value was 93% (95% CI [0.843, 0.977]). Comparison of time-to-progression of ctDNA+ and ctDNA- patients using the log-rank test resulted in a p-value of 0.0058. Comparison of survival times of ctDNA+ and ctDNA- patients resulted in a p-value of 0.0333. Multivariate analyses of times-to-progression resulted in ctDNA-status (p = 0.0022, hazard ratio (HR) = 7.098) and neoadjuvant therapy (p = 0.0010, HR = 6.618) as significant parameters. Conclusions: Even in this small cohort of CRC UICC stage II/III patients, MRD detection in post-surgery plasma is the strongest predictor of shorter time to progression. Ultra-deep sequencing of cfDNA samples did not influence MRD detection on a patient-level. *for Research Use Only; not for use in diagnostic procedures.
Case 17 (2013)

Case presentations focus on mapping techniques, diagnosis, and proper catheter placement for successful ablation of arrhythmias. This case focuses on intractable atrial fibrillation, multiple atrial flutters, bilateral conduction block, accessory pathway conduction, junctional tachycardia, premature atrial contractions, H-A interval, H-H interval, H-V interval, A-H interval, and heart block.
ChemInform Abstract: Highly Selective Palladium‐Catalyzed Cross‐Coupling of Secondary Alkylzinc Reagents with Heteroaryl Halides. (2015)

Abstract A general Pd‐based catalytic system is developed to allow the cross‐coupling of a broad spectrum of hetaryl halides with secondary Grignard reagents.
Microstructures of Oxidized Primary Carbides on Superalloy Inconel 718 (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Immature and Neurally Differentiated Mouse Embryonic Stem Cells Do Not Express a Functional Fas/Fas Ligand System (2007)

The potential of pluripotent embryonic stem (ES) cells to develop into functional cells or tissue provides an opportunity in the development of new therapies for many diseases including neurodegenerative disorders. The survival of implanted cells usually requires systemic immunosuppression, however, which severely compromises the host immune system, leading to complications in clinical transplantation. An optimal therapy would therefore be the induction of specific tolerance to the donor cells, while otherwise preserving functional immune responses. Fas ligand (FasL) is expressed in activated lymphocytes as well as cells in "immune-privileged" sites including the central nervous system. Its receptor, Fas, is expressed on various immune-reactive cell types, such as activated natural killer and T cells, monocytes, and polymorphic mononucleocytes, which can undergo apoptosis upon interaction with FasL. To render transplanted cells tolerant to host cellular immune responses, we genetically engineered mouse ES cells to express rat FasL (rFasL). The rFasL-expressing ES cells were analyzed for survival during in vitro neurodifferentiation and after transplantation to the rat brain without further immunosuppression. Although control transfected HEK-293T cells expressed functional rFasL, immature and differentiated mouse ES cells did not express the recombinant rFasL surface protein. Furthermore, there was no evidence for functional endogenous Fas and FasL expression on either ES cells or on neural cells after in vitro differentiation. Moreover, implanted rFasL-engineered ES cells did not survive in the rat brains in the absence of the immunosuppressive agent cyclosporine A. Our results indicate that immature and differentiated mouse ES cells do not express a functional Fas/FasL system. Disclosure of potential conflicts of interest is found at the end of this article.
Global testing of a consensus solubility assessment to enhance robustness of the WHO biopharmaceutical classification system (2020)

The WHO Biopharmaceutical Classification System (BCS) is a practical tool to identify active pharmaceutical ingredients (APIs) that scientifically qualify for a waiver of in vivo bioequivalence studies. The focus of this study was to engage a global network of laboratories to experimentally quantify the pH-dependent solubility of the highest therapeutic dose of 16 APIs using a harmonized protocol. Intra-laboratory variability was ≤5 %, and no apparent association of inter-laboratory variability with API solubility was discovered. Final classification "low solubility" vs "high solubility" was consistent among laboratories. In comparison to the literature-based provisional 2006 WHO BCS classification, three compounds were re-classified from "high" to "low-solubility". To estimate the consequences of these experimental solubility results on BCS classification, dose-adjusted in silico predictions of the fraction absorbed in humans were performed using GastroPlus®. Further expansion of these experimental efforts to qualified APIs from the WHO Essential Medicines List is anticipated to empower regulatory authorities across the globe to issue scientifically-supported guidance regarding the necessity of performing in vivo bioequivalence studies. Ultimately, this will improve access to affordable generic products, which is a critical prerequisite to reach Universal Health Coverage.
UrbanLoco: A Full Sensor Suite Dataset for Mapping and Localization in Urban Scenes (2020)

Mapping and localization is a critical module of autonomous driving, and significant achievements have been reached in this field. Beyond Global Navigation Satellite System (GNSS), research in point cloud registration, visual feature matching, and inertia navigation has greatly enhanced the accuracy and robustness of mapping and localization in different scenarios. However, highly urbanized scenes are still challenging: LIDAR- and camera-based methods perform poorly with numerous dynamic objects; the GNSS-based solutions experience signal loss and multi-path problems; the inertia measurement units (IMU) suffer from drifting. Unfortunately, current public datasets either do not adequately address this urban challenge or do not provide enough sensor information related to map-ping and localization. Here we present UrbanLoco: a mapping/localization dataset collected in highly-urbanized environments with a full sensor-suite. The dataset includes 13 trajectories collected in San Francisco and Hong Kong, covering a total length of over 40 kilometers. Our dataset includes a wide variety of urban terrains: urban canyons, bridges, tunnels, sharp turns, etc. More importantly, our dataset includes information from LIDAR, cameras, IMU, and GNSS receivers. Now the dataset is publicly available through the link in the footnote <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> .
Separation efficiency of slurry-packed liquid chromatography microcolumns with very small inner diameters (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSeparation efficiency of slurry-packed liquid chromatography microcolumns with very small inner diametersKarl Erik. Karlsson and Milos. NovotnyCite this: Anal. Chem. 1988, 60, 17, 1662–1665Publication Date (Print):September 1, 1988Publication History Published online1 May 2002Published inissue 1 September 1988https://pubs.acs.org/doi/10.1021/ac00168a006https://doi.org/10.1021/ac00168a006research-articleACS PublicationsRequest reuse permissionsArticle Views651Altmetric-Citations184LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Regioselective Synthesis of 2,8‐Disubstituted 4‐Aminopyrido[3,2‐d]pyrimidine‐6‐carboxylic Acid Methyl Ester Compounds. (2012)

Abstract The use of appropriate conditions and reagents allows regioselective formation of a number of differently substituted pyridopyrimidines.
Preparation of diagnostic polyclonal and monoclonal antibodies against outer envelope proteins of Serpulina pilosicoli (1998)

The purpose of this study was to prepare specific sera for use in the rapid detection and identification of the intestinal spirochaete Serpulina pilosicoli. In Western blot analysis, with pig antiserum which was raised against whole cells of S. pilosicoli and absorbed with outer envelope protein extracts from S. hyodysenteriae and S. innocens, a prominent protein with Mr of c. 72 kDa was consistently identified in outer envelope preparations of S. pilosicoli strains. Immunogold labelling demonstrated that this was located on the outer surface of intact S. pilosicoli cells. Two monoclonal antibodies (MAbs), designated C12 and M96, were raised against the protein. Although C12 reacted with a protein band of c. 72 kDa, this was also present in preparations from strains of other Serpulina spp. examined. MAb M96 reacted with an 80-kDa protein which was present only in preparations made from strains of S. pilosicoli. This was used in Western blot analysis and in an immunodot-blot assay with outer envelope extracts to specifically identify S. pilosicoli strains isolated from man, pigs, dogs and poultry. An indirect immunofluorescence test with MAb M96 also was used to detect and identify whole S. pilosicoli cells. Therefore, both the cross-absorbed antiserum and MAb M96 are potentially useful reagents for the detection and identification of S. pilosicoli.