gebhart/patrepeval huggingface dataset:
Multicenter phase II study of combined neoadjuvant docetaxel and androgen ablation (ADT) prior to radical prostatectomy (RP) for patients (pts) with high risk localized prostate cancer (LCaP): Pathologic outcomes and 3-year follow-up analyses (2007)

5002 Background: Pts with high risk LCaP (cT3, Gleason score &gt; 7 &amp;/or PSA &gt; 20) have an increased risk of relapse with a biochemical failure rate of &gt;50% at 3 years after RP. Docetaxel is active in hormone refractory prostate cancer &amp; potentially beneficial if combined with ADT for treatment naïve disease. The objectives of this trial were to assess the pathologic outcomes &amp; feasibility of docetaxel + ADT in men with LCaP prior to RP. Methods: A phase II multi-center study of newly diagnosed previously untreated pts with clinically LCaP with high-risk features. All pts received ADT (buserelin acetate 6.3 mg q8 weeks x 3 and anti-androgen for 4 weeks) plus docetaxel (35 mg/m 2 weekly for 6 out of 8 weeks for 3 cycles) prior to RP. Results: 72 men with a median age of 59 years (range 46–78) were enrolled at 6 sites. Baseline characteristics included: clinical stage T1C, T2 &amp; T3 in 14%, 47% &amp; 39%; and Gleason score &lt;7, 7 &amp; &gt;7 in 10%, 30% &amp; 60% of pts; respectively. Median baseline PSA was 10.8 μg/L (range 1.6–65.6) with PSA &lt; 10 in 47%, 10–20 in 24% &amp; &gt;20 in 29% of pts. Eight pts did not complete protocol therapy because of toxicity (n=4), withdrawal of consent (n=1), or other reasons (n=3). 1 pt had myocardial infarction day 1 post-operatively &amp; 1 pt had DVT 1.5 months after RP. No other major post-operative complications were reported. Of the 64 pts completing protocol therapy, 2 had a complete pathologic response and pathologic stage was T2 in 34 (53%) and T3 in 28 (44%) pts. Four pts had N1 disease &amp; positive surgical margins were identified in 17 (27%). On multivariate Cox regression analysis only baseline Gleason score (=7 vs. &gt;7) was associated with PSA recurrence-free survival (hazard ratio 4.58, 95% CI 1.32–15.93). At a median follow-up of 42.7 months (range 25.6–65.6), 19 (30%) pts have relapsed. Three pts have died at 32.0, 40.0 &amp; 40.3 months, with all deaths attributed to prostate cancer. Conclusions: Combined ADT and docetaxel prior to RP was feasible and resulted in encouraging pathologic outcomes and PSA- recurrence free survival. These data further support the rationale for randomized trials determining the efficacy of chemo-hormonal therapy in pts with clinically LCaP. [Table: see text]
Bounding Higher Order Ionosphere Errors for the Dual Frequency GPS User (2006)

[1] Civil signals at L2 and L5 frequencies herald a new phase of Global Positioning System (GPS) performance. Dual-frequency users typically assume a first-order approximation of the ionosphere index of refraction, combining the GPS observables to eliminate most of the ranging delay, on the order of meters, introduced into the pseudoranges. This paper estimates the higher-order group and phase errors that occur from assuming the ordinary first-order dual-frequency ionosphere model using data from the Federal Aviation Administration's Wide Area Augmentation System (WAAS) network on a solar maximum quiet day and an extremely stormy day postsolar maximum. We find that during active periods, when ionospheric storms may introduce slant range delays at L1 as high as 100 m, the higher-order group errors in the L1–L2 or L1–L5 dual-frequency combination can be tens of centimeters. The group and phase errors are no longer equal and opposite, so these errors accumulate in carrier smoothing of the dual-frequency code observable. We show the errors in the carrier-smoothed code are due to higher-order group errors and, to a lesser extent, to higher-order phase rate errors. For many applications, this residual error is sufficiently small as to be neglected. However, such errors can impact geodetic applications as well as the error budgets of GPS Augmentation Systems providing Category III precision approach.
Proposal and Evaluation of Visual Haptics for Manipulation of Remote Machine System (2020)

Remote machine systems have drawn a lot of attention owing to accelerations of virtual reality (VR), augmented reality (AR), and the fifth generation (5G) networks. Despite recent trends of developing autonomous systems, the realization of sophisticated dexterous hand that can fully replace human hands is considered to be decades away. It is also extremely difficult to reproduce the sensilla of complex human hands. On the other hand, it is known that humans can perceive haptic information from visual information even without any physical feedback as cross modal sensation between visual and haptics sensations or pseudo haptics. In this paper, we propose a visual haptic technology, where haptic information is visualized in more perceptual images overlaid at the contact points of a remote machine hand. The usability of the proposed visual haptics was evaluated by subject's brain waves aiming to find out a new approach for quantifying “sense of oneness”. In our proof-of-concept experiments using VR, subjects are asked to operate a virtual arm and hand presented in the VR space, and the performance of the operation with and without visual haptics information as measured with brain wave sensing. Consequently, three results were verified. Firstly, the information flow in the brain were significantly reduced with the proposed visual haptics for the whole α, βand θ-waves by 45% across nine subjects. This result suggests that superimposing visual effects may be able to reduce the cognitive burden on the operator during the manipulation for the remote machine system. Secondly, high correlation (Pearson correlation factor of 0.795 at a p-value of 0.011) was verified between the subjective usability points and the brainwave measurement results. Finally, the number of the task successes across sessions were improved in the presence of overlaid visual stimulus. It implies that the visual haptics image could also facilitate operators' pre-training to get skillful at manipulating the remote machine interface more quickly.
Attenuated thermoregulatory sweating and cutaneous vasodilation after 14-day bed rest in humans (2004)

We investigated the effect of head-down bed rest (HDBR) for 14 days on thermoregulatory sweating and cutaneous vasodilation in humans. Fluid intake was ad libitum during HDBR. We induced whole body heating by increasing skin temperature for 1 h with a water-perfused blanket through which hot water (42 degrees C) was circulated. The experimental room was air-conditioned (27 degrees C, 30-40% relative humidity). We measured skin blood flow (chest and forearm), skin temperatures (chest, upper arm, forearm, thigh, and calf), and tympanic temperature. We also measured sweat rate by the ventilated capsule method in which the skin area for measurement was drained by dry air conditioned at 27 degrees C under similar skin temperatures in both trials. We calculated cutaneous vascular conductance (CVC) from the ratio of skin blood flow to mean blood pressure. From tympanic temperature-sweat rate and -CVC relationships, we assessed the threshold temperature and sensitivity as the slope response of variables to a given change in tympanic temperature. HDBR increased the threshold temperature for sweating by 0.31 degrees C at the chest and 0.32 degrees C at the forearm, whereas it reduced sensitivity by 40% at the chest and 31% at the forearm. HDBR increased the threshold temperature for cutaneous vasodilation, whereas it decreased sensitivity. HDBR reduced plasma volume by 11%, whereas it did not change plasma osmolarity. The increase in the threshold temperature for sweating correlated with that for cutaneous vasodilation. In conclusion, HDBR attenuated thermoregulatory sweating and cutaneous vasodilation by increasing the threshold temperature and decreasing sensitivity. HDBR increased the threshold temperature for sweating and cutaneous vasodilation by similar magnitudes, whereas it decreased their sensitivity by different magnitudes.
Dataset for Ultrafast perturbation maps as a quantitative tool for testing of multi-port photonic devices (2018)

Dataset supporting 'Ultrafast perturbation maps as a quantitative tool for testing of multi-port photonic devices' published in Nature Communications.
CELL PENETRATING PEPTIDE DECORATED-MAGNETIC POROUS SILICON NANORODS FOR GLIOBLASTOMA IMAGING AND THERAPY (2022)

International audience
Randomized controlled phase IIa clinical trial of safety, pharmacokinetics and pharmacodynamics of tenofovir and tenofovir plus levonorgestrel releasing intravaginal rings used by women in Kenya (2023)

NCT03762382 [https://clinicaltrials.gov/ct2/show/NCT03762382].
Surface Reengineering of RPA70N Enables Cocrystallization with an Inhibitor of the Replication Protein A Interaction Motif of ATR Interacting Protein (2013)

Replication protein A (RPA) is the primary single-stranded DNA (ssDNA) binding protein in eukaryotes. The N-terminal domain of the RPA70 subunit (RPA70N) interacts via a basic cleft with a wide range of DNA processing proteins, including several that regulate DNA damage response and repair. Small molecule inhibitors that disrupt these protein-protein interactions are therefore of interest as chemical probes of these critical DNA processing pathways and as inhibitors to counter the upregulation of DNA damage response and repair associated with treatment of cancer patients with radiation or DNA-damaging agents. Determination of three-dimensional structures of protein-ligand complexes is an important step for elaboration of small molecule inhibitors. However, although crystal structures of free RPA70N and an RPA70N-peptide fusion construct have been reported, RPA70N-inhibitor complexes have been recalcitrant to crystallization. Analysis of the P61 lattice of RPA70N crystals led us to hypothesize that the ligand-binding surface was occluded. Surface reengineering to alter key crystal lattice contacts led to the design of RPA70N E7R, E100R, and E7R/E100R mutants. These mutants crystallized in a P212121 lattice that clearly had significant solvent channels open to the critical basic cleft. Analysis of X-ray crystal structures, target peptide binding affinities, and (15)N-(1)H heteronuclear single-quantum coherence nuclear magnetic resonance spectra showed that the mutations do not result in perturbations of the RPA70N ligand-binding surface. The success of the design was demonstrated by determining the structure of RPA70N E7R soaked with a ligand discovered in a previously reported molecular fragment screen. A fluorescence anisotropy competition binding assay revealed this compound can inhibit the interaction of RPA70N with the peptide binding motif from the DNA damage response protein ATRIP. The implications of the results are discussed in the context of ongoing efforts to design RPA70N inhibitors.
Evaluation of Radiation Exposure from a Consumer Product (1999)

Radiation exposure from a pillow was analyzed. According to an advertisement of the pillow, this radioactive consumer product contains enough amounts of radioactive materials to induce radiation hormesis effects. The pillow consists of the filling chips made from kneading mineral ores and the polynosic lining contains natural radioactive ores.Aγ-ray analysis of the pillow using pureGe-MCA reveals that there exist radioactivities of thorium and uranium series mixtures in it at concentration of 0.58% by the weight.The observations of a chip surface by a scanning electron microscope show that the shapes of two sides are different each other. There are lots of sharp protuberances on the outside of the chip.To determine the direct external exposures from the pillow, film badges were placed on the pillow for 210hand2555h.The dose equivalents of 210hexposure was under 0.1mSvwhich is a detection limit ofa γ-ray by the film badges. However, that of 2555hexposure was over 0.1mSvless than 0.15mSv.Quantities of internal exposures from inhalation of the vaporizedRnwere measured by a Lucas Cell. It was 79Bq/m3.There is no necessity for anxious about being broken in health inhaling theRn-gass.
Research on Environmental Health Interventions: Ethical Problems and Solutions (2005)

This article reviews a variety of ethical issues one must consider when conducting research on environmental health interventions on human subjects. The paper uses the Kennedy Krieger Institute lead abatement study as well as a hypothetical asthma study to discuss questions concerning benefits and risks, risk minimization, safety monitoring, the duty to warn, the duty to report, the use of control groups, informed consent, equitable subject selection, privacy, conflicts of interest, and community consultation. Research on environmental health interventions can make an important contribution to our understanding of human health and disease prevention, provided it is conducted in a manner that meets prevailing scientific, ethical, and legal standards for research on human subjects.
Defining terms for crystalline silicon solar cells (1994)

Abstract Sandia National Laboratories manages the US Department of Energy's program supporting photovoltaic technology based on crystalline silicon. In this role, Sandia has favored terminology for use in this program. Terms defined and presented here are for the description of different types of crystalline silicon based on grain size, the description of cell area and the description of module area. While these terms have not been formally established as an international standard, it is hoped that the majority of the photovoltaic community will adopt these terms voluntarily.
Calpain as a novel target for treating acute neurodegenerative disorders (1995)

Calpains are cytosolic, neutral proteases that normally exist in an inactive or quiescent state. They require higher than normal levels of calcium for activation which, once accomplished, lead to irreversible proteolysis of numerous cytoskeletal, membrane-associated and regulatory proteins. Because of these characteristics, calpain is gaining attention as a potentially important pathogenic variable in ischemic neuronal death. This manuscript explores this hypothesis by briefly reviewing current support for the role played by calpain in ischemic neurodegeneration, and then discussing a series of recently published studies which: 1. offer further evidence for the hypothesis, and 2. provide direct support for the idea that selective inhibition of calpain can greatly limit the neuronal damage that would normally occur following both global as well as focal brain ischemia. Thus, the data reviewed in this manuscript support the ideas that unregulated activation and proteolysis of intraneuronal calpain plays a significant role in the brain damage that occurs following an ischemic event and that delivering selective and membrane permeant calpain inhibitors to ischemic tissue may provide a powerfully effective therapeutic means of limiting neuronal damage.
The Recycler Electron Cooler (2013)

The Recycler Electron cooler was the first (and so far, the only) cooler working at a relativistic energy (γ = 9.5). It was successfully developed in 1995-2004 and was in operation at Fermilab in 2005-2011, providing cooling of antiprotons in the Recycler ring. This paper describes the cooler, difficulties in achieving the required electron beam parameters and the ways to overcome them, cooling measurements, and details of operation.
CDNF Protein Therapy in Parkinson’s Disease (2019)

Neurotrophic factors (NTF) are a subgroup of growth factors that promote survival and differentiation of neurons. Due to their neuroprotective and neurorestorative properties, their therapeutic potential has been tested in various neurodegenerative diseases. Bioavailability of NTFs in the target tissue remains a major challenge for NTF-based therapies. Various intracerebral delivery approaches, both protein and gene transfer-based, have been tested with varying outcomes. Three growth factors, glial cell-line derived neurotrophic factor (GDNF), neurturin (NRTN) and platelet-derived growth factor (PDGF-BB) have been tested in clinical trials in Parkinson's disease (PD) during the past 20 years. A new protein can now be added to this list, as cerebral dopamine neurotrophic factor (CDNF) has recently entered clinical trials. Despite their misleading names, CDNF, together with its closest relative mesencephalic astrocyte-derived neurotrophic factor (MANF), form a novel family of unconventional NTF that are both structurally and mechanistically distinct from other growth factors. CDNF and MANF are localized mainly to the lumen of endoplasmic reticulum (ER) and their primary function appears to be modulation of the unfolded protein response (UPR) pathway. Prolonged ER stress, via the UPR signaling pathways, contributes to the pathogenesis in a number of chronic degenerative diseases, and is an important target for therapeutic modulation. Intraputamenally administered recombinant human CDNF has shown robust neurorestorative effects in a number of small and large animal models of PD, and had a good safety profile in preclinical toxicology studies. Intermittent monthly bilateral intraputamenal infusions of CDNF are currently being tested in a randomized placebo-controlled phase I-II clinical study in moderately advanced PD patients. Here, we review the history of growth factor-based clinical trials in PD, and discuss how CDNF differs from the previously tested growth factors.
HW2VEC: a Graph Learning Tool for Automating Hardware Security (2021)

The time-to-market pressure and continuous growing complexity of hardware designs have promoted the globalization of the Integrated Circuit (IC) supply chain. However, such globalization also poses various security threats in each phase of the IC supply chain. Although the advancements of Machine Learning (ML) have pushed the frontier of hardware security, most conventional ML-based methods can only achieve the desired performance by manually finding a robust feature representation for circuits that are non-Euclidean data. As a result, modeling these circuits using graph learning to improve design flows has attracted research attention in the Electronic Design Automation (EDA) field. However, due to the lack of supporting tools, only a few existing works apply graph learning to resolve hardware security issues. To attract more attention, we propose HW2VEC, an open-source graph learning tool that lowers the threshold for newcomers to research hardware security applications with graphs. HW2VEC provides an automated pipeline for extracting a graph representation from a hardware design in various abstraction levels (register transfer level or gate-level netlist). Besides, HW2VEC users can automatically transform the non-Euclidean hardware designs into Euclidean graph embeddings for solving their problems. In this paper, we demonstrate that HW2VEC can achieve state-of-the-art performance on two hardware security-related tasks: Hardware Trojan Detection and Intellectual Property Piracy Detection. We provide the time profiling results for the graph extraction and the learning pipelines in HW2VEC.
Diffraction efficiencies of thin phase gratings with arbitrary grating shape (1978)

Diffraction by thin refractive-index gratings of arbitrary periodic shape is treated. Three analytical approaches are indicated and are shown to be equivalent. Resultant expressions for the diffraction efficiencies are given for all diffracted orders.
Laser-Generated Scholte Waves in Floating Microparticles (2023)

This study aims to demonstrate the generation and detection of Scholte waves inside polystyrene microparticles. This was proven using both experimental analysis and COMSOL simulation. Microspheres of different sizes were excited optically with a pulsed laser (532 nm), and the acoustic signals were detected using a transducer (40 MHz). On analyzing the laser-generated ultrasound signals, the results obtained experimentally and from COMSOL are in close agreement both in the time and frequency domain. A simplified analysis of Scholte wave generation by laser irradiation for homogeneous, isotropic microspheres is presented. The theoretical wave velocity of the Scholte wave was calculated and found close to our experimental results. A representation of pressure wave motion showing the Scholte wave generation is presented at different times.
Intraprosthetic Dislocation of Dual-Mobility Bearings Associated with Closed Reduction (2015)

When dislocation of a dual-mobility bearing occurs, the surgeon should consider performing a careful closed reduction with muscle paralysis and use of fluoroscopic guidance in the operating room to avoid intraprosthetic dislocation.
SPVN (2007)

We present SPVN (Scalable Parallel Visual Networking), a new application framework for interactive visualization of large datasets. We designed SPVN with four main goals in mind. First, we wanted to make it easier for developers to write visualization applications that can handle massive datasets and deliver interactive frame rates. SPVN provides developers with efficient implementations of many optimization techniques such as spatialization, simplification, view-frustum culling, occlusion culling, multithreading, and prefetching. Second, we wanted developers to better leverage the performance and scalability of a cluster of inexpensive rendering servers, while insulating them from the complexities of distributed programming. SPVN provides implementations of sort-first rendering with dynamic load balancing, sort-last rendering with depth-order and binary-swap image compositing, and a distributed shared memory mechanism that gives programmers the illusion that all machines have all the data at all times. Third, we wanted to support multiple low-level rendering libraries. SPVN separates modeling from rendering so that the same scene can be rendered by different back-ends (e.g., OpenGL, DirectX, or ray tracing). Finally, we wanted SPVN to be easy to use and extend. SPVN uses the familiar concept of a scene graph, applies many well-established design patterns (e.g., smart pointers, factories, observers, and visitors), and allows for extensions of shape classes, rendering algorithms, and file formats using registry and plug-in mechanisms. We have used SPVN to develop both remote and immersive visualization applications, and found that SPVN reduces the amount of time and money it takes to write such applications.
Relationship between past myocardial infarction, periodontal disease and Porphyromonas gingivalis serum antibodies: A case-control study (2017)

There was an association between CP and past MI, which was independent of classical CVD risk factors and confirmed by an association between past MI and immunological reaction against P. gingivalis gingipains.
Metric and other international units for agriculture (1978)

By the time 1980 rolls arou nd , Missouri corn yields should average more than 6,300 kilograms per heGtare.Fuel economy for intermediate size cars should be approaching 8.5 kilometers per liter.And the United States will be well on its way to adopting the International System of U ni ts or, as it is more commonly referred to, the metric system.The International System of Units was forma ll y adopted by the countri es of the world in 1960.This system has six standard units from which all measurements can be derived.These six units are: meter (m): Standard unit of length first defined by the French government nearly 200 years ago.Even though the United States retained the English system (inches, feet, yards) of length, we have used the international standard meter to derive these units since 1889.kilogram (Kg): Unit of mass (weight) originally defined as the weight of 1,000 cubic centimeters of pure water.second (s): Standard unit of time already in use in the United States.degree Kelvin: Measure of temperature .The Kelvin degree is the same size as a degree on the Celsius or Centigrade scale which is used in most countries of the world.