gebhart/patrepeval huggingface dataset:
Danaparoid sodium lowers proteinuria in diabetic nephropathy. (1997)

Diabetic nephropathy is a progressive renal disease with thickening of the glomerular basement membrane and mesangial expansion and proliferation as histological hallmarks. The presence of the glycosaminoglycan side chains of heparan sulfate proteoglycan, an important constituent of the glomerular basement membrane, is decreased in diabetic nephropathy proportionally to the degree of proteinuria. Danaparoid sodium is a mixture of sulfated glycosaminoglycans consisting mainly of heparan sulfate. The study presented here involved performing a randomized placebo-controlled crossover study with danaparoid sodium in diabetic patients with overt proteinuria. The aim of the study was to evaluate the effect on proteinuria and safety/tolerability. Nine patients completed the study, without major side effects; the crossover study consisted of two 6-wk periods of treatment with 750 anti-Xa units danaparoid sodium subcutaneously once-daily or placebo. Following danaparoid sodium, significant declines of both albuminuria and proteinuria were found. After danaparoid sodium, the albumin excretion ratio standardized for urinary creatinine reduced with 17% in comparison with an increase of 23% after placebo (95% confidence interval of the difference,-75.9-3.9%; P = 0.03). The percentage change of the urinary protein excretion corrected for urinary creatinine differed at 8 wk significantly between both treatment arms (P = 0.001). Additional parameters for safety as hematological, hemostasis, biochemical parameters, and fundusphotography did not show any clinically significant difference for both groups. Only two patients had minor skin hematomas at the injection site while using danaparoid sodium. In conclusion, the supplementation was found to be feasible and was not associated with side effects. A significant decline of proteinuria was found. More prospective dose-finding and long-term studies must be performed to see whether danaparoid sodium could not only induce a reduction of proteinuria but also halt the progression of renal disease.
Preparation of Perovskite-type Oxides with Large Surface Area by Citrate Process (1987)

Abstract Well-crystallized perovskite-type oxides could be synthesized at temperatures as low as 550–650 °C by the calcination of amorphous citrate complex precursors. The large specific surface areas of the oxides obtained suggest that the citrate process is very promising for preparing perovskite-type oxide catalysts for practical use.
Decoration of multiwall carbon nanotubes with nickel nanoparticles: effect of deposition strategy on metal dispersion and performance in the hydrogenation of p-chloroacetophenone (2011)

The sonochemical deposition of nickel nanoparticles onto the multiwall carbon nanotube aggregates leads to a uniformly distributed metal phase at high loadings and an average nickel crystal size of 4–8 nm at a 25–50 wt% nickel content. Its application enhances the catalytic activity of Ni/multiwall carbon nanotube material in the selective hydrogenation of chloroacetophenone by factors of 2–18, as compared with that prepared by traditional decoration methods.
Retracted: Design of Nano Thermoelectric Generator for Wireless Nano-Sensor Network (2020)

This paper proposes a nano vitality collector dependent on temperature angle utilizing thermoelectric materials. A thermoelectric generator (TEG) produces electrical vitality from temperature contrast. Right now, the gadget is planned to fit as a fiddle for the simplicity of creation.nanoscale gadgets render assortment of ar WNSNs include nanosensors that are familiar with Nano The thermoelectric generator is a wellspring of a sustainable power source. It can change over warmth vitality to electrical vitality utilizing the Seebeck coefficient of the materials. There has been a quick headway in microelectronics which has made the nanotechnology huge and it has prodded the development of remote correspondence. For an occasion, nanosensors can distinguish any concoction organization in fixations as low as one section for every billion In this manner, in thought to the one of a kind qualities of nanosensors, it is impractical and infeasible to fuse any extra circuit in the equipment of nanosensors. Such a working situation of nanosensors gadgets makes an objective of vitality safeguarding because of constrained design battery assets inserted into it. transceiver and nanoantenna working at the Terahertz recurrence band (0.1-10THz). Up until now, analysts have concentrated on vitality productivity in WSNs however the vitality issue in WNSNs has not been tended to fundamentally in the current writing. The reenactment examination is acted in MATLAB Software to experimentally research the exhibition of proposed vitality adjusted bunching consolidating the proper ClusterHead (CH) determination. The fundamental extent of this structured gadget is to give the capacity to remote, biomedical and IoT sensors which devour less vitality to work. Reenactment of this examinationworkhasbeendone in COMSOL Multiphysics.
High expression of RelA/p65 is associated with activation of nuclear factor-κB-dependent signaling in pancreatic cancer and marks a patient population with poor prognosis (2007)

Activation of nuclear factor-kappaB (NF-kappaB) signaling was observed in pancreatic adenocarcinoma cell lines and tumours. However, information on the expression of RelA/p65, the major transcription activating NF-kappaB subunit, in these carcinomas and possible correlations thereof with NF-kappaB activation and patient survival is not available. To provide this missing translational link, we analysed expression of RelA/p65 in 82 pancreatic adenocarcinomas by immunohistochemistry. Moreover, we measured activation of the NF-kappaB pathway in 11 tumours by quantitative PCR for NF-kappaB target genes. We observed strong cytoplasmic or nuclear expression of RelA/p65 in 42 and 37 carcinomas, respectively. High cytoplasmic and nuclear expression of RelA/p65 had negative prognostic impact with 2-year survival rates for patients without cytoplasmic or nuclear RelA/p65 positivity of 41 and 40% and rates for patients with strong cytoplasmic or nuclear RelA/p65 expression of 22 and 20%, respectively. High RelA/p65 expression was correlated to increased expression of NF-kappaB target genes. The observation that high expression of RelA/p65 is correlated to an activation of the NF-kappaB pathway and indicates poor patient survival identifies a patient subgroup that might particularly benefit from NF-kappaB-inhibiting agents in the treatment of pancreatic cancer. Based on our findings, this subgroup could be identified by applying simple immunohistochemical techniques.
Quantum belief propagation: An algorithm for thermal quantum systems (2007)

We present an accurate numerical algorithm, called quantum belief propagation, for simulation of one-dimensional quantum systems at nonzero temperature. The algorithm exploits the fact that quantum effects are short-range in these systems at nonzero temperature, decaying on a length scale inversely proportional to the temperature. We compare to exact results on a spin-$1∕2$ Heisenberg chain. Even a very modest calculation, requiring diagonalizing only ten-by-ten matrices, reproduces the peak susceptibility with a relative error of less than ${10}^{\ensuremath{-}5}$, while more elaborate calculations further reduce the error.
Molecular and Immunological Analyses of the Mycobacterium avium Homolog of the Immunodominant Mycobacterium leprae 35-Kilodalton Protein (1998)

The analysis of host immunity to mycobacteria and the development of discriminatory diagnostic reagents relies on the characterization of conserved and species-specific mycobacterial antigens. In this report, we have characterized the Mycobacterium avium homolog of the highly immunogenic M. leprae 35-kDa protein. The genes encoding these two proteins were well conserved, having 82% DNA identity and 90% identity at the amino acid level. Moreover both proteins, purified from the fast-growing host M. smegmatis, formed multimeric complexes of around 1000 kDa in size and were antigenically related as assessed through their recognition by antibodies and T cells from M. leprae-infected individuals. The 35-kDa protein exhibited significant sequence identity with proteins from Streptomyces griseus and the cyanobacterium Synechoccocus sp. strain PCC 7942 that are up-regulated under conditions of nutrient deprivation. The 67% amino acid identity between the M. avium 35-kDa protein and SrpI of Synechoccocus was spread across the sequences of both proteins, while the homologous regions of the 35-kDa protein and the P3 sporulation protein of S. griseus were interrupted in the P3 protein by a divergent central region. Assessment by PCR demonstrated that the gene encoding the M. avium 35-kDa protein was present in all 30 M. avium clinical isolates tested but absent from M. intracellulare, M. tuberculosis, or M. bovis BCG. Mice infected with M. avium, but not M. bovis BCG, developed specific immunoglobulin G antibodies to the 35-kDa protein, consistent with the observation that tuberculosis patients do not recognize the antigen. Strong delayed-type hypersensitivity was elicited by the protein in guinea pigs sensitized with M. avium.
Predicting the potentials, solubilities and stabilities of metal-acetylacetonates for non-aqueous redox flow batteries using density functional theory calculations (2017)

New active materials are needed to improve the performance and reduce the cost of non-aqueous redox flow batteries (RFBs) for grid-scale energy storage applications.
High Critical Current YBa 2 Cu 3 O 7−δ Thick Films on Improved Rolling‐Assisted Biaxially Textured Substrates (RABiTS ™ ) (2005)

YBa 2 Cu 3 O 7−δ (YBCO) films with thicknesses ranging from 1.0 to 6.4 μm were deposited by pulsed laser deposition on rolling‐assisted biaxially textured substrates (RABiTS). The RABiTS were of the configuration CeO 2 /YSZ/Y 2 O 3 /Ni–3 at.% W. As the YBCO film thickness increased, I c continued to increase and reached ∼300 A/cm width for a 4.3 μm‐thick YBCO film. Commonly observed mechanisms for J c decrease with increasing YBCO film thickness were not observed. Homogeneous microstructures obtained in even the thickest YBCO films, suggest that the I c /width can still be enhanced considerably.
1/F Noise in MoS2 Field Effect Transistors with Channel Length Variation (2015)

Field effect transistors (FETs) based on emerging nanoscale channel materials have numerous applications including post-CMOS logic for digital computing, communication and biochemical sensing. However, in fundamental level each of these applications requires tight scrutiny of carrier transport as the device operates in the desired regime and in the proposed environment. One of the important characteristics is to analyze the 1/ f noise spectroscopy of the electronic device. In this paper we fabricate multilayer (15 atomic layer) MoS 2 transistors of two different channel lengths (1µm and 2µm) and study the flicker noise in the devices at room temperature and ambient conditions; both devices being fabricated following the same process flows on a single micro-mechanically exfoliated flake of MoS 2 ; thereby eliminating variability of 1/ f noise from fabrication standpoints. Channel dominated 1/ f noise with Hooge’s mobility fluctuation model for the devices were extracted from the bias dependent noise spectra. The noise characteristics of the devices are stable over several months of exposure to ambient. The robustness of the channel to its ambient and stability of current fluctuations reveal MoS 2 as an emerging candidate for reliable sensing. Figure shows 1/ f noise spectra of MoS 2 FET with 15 atomic layer thick back-gated channels with Cr/Au source and drain electrodes. Channel lengths of 1µm and 2µm were compared for this study. Key words: 1/ f noise, MoS 2 FETs, biochemical sensing Figure 1
The power of play: how spontaneous, imaginative activities lead to happier, healthier children (2007)

Best-selling author and distinguished childcare expert David Elkind takes on the over-scheduled child syndrome, providing parents with an understanding of, and appreciation for the powerful role of in healthy emotional and academic development. In modern childhood, free, unstructured play time is being replaced more and more by academics, lessons, competitive sports and passive entertainment. While parents may worry that their children will be at a disadvantage if they are not engaged in constant learning, child development expert David Elkind reassures us that imaginative play goes far to prepare children for academic and social success, perhaps further than the panoply of educational products geared towards youngsters. To restore play's good name, best-selling author and internationally-known educator David Elkind shows how creative, spontaneous play fosters healthy mental and social development and sets the stage for academic learning. For example, children learn mutual respect and cooperation through role-playing and the negotiation of rules, which in turn prepares them for successful classroom learning. In simply playing with rocks, a child could discover properties of counting and shapes, and even a toddler's babbling is an important precursor to language. Finally, Elkind suggests ways to restore play's respected place in children's lives, at home, at school and in the larger community.
Particulate Mycobacterial Vaccines Induce Protective Immunity against Tuberculosis in Mice (2021)

Currently available vaccines fail to provide consistent protection against tuberculosis (TB). New, improved vaccines are urgently needed for controlling the disease. The mycobacterial antigen fusions H4 (Ag85B-TB10.4) and H28 (Ag85B-TB10.4-Rv2660c) have been shown to be very immunogenic and have been considered as potential candidates for TB vaccine development. However, soluble protein vaccines are often poorly immunogenic, but augmented immune responses can be induced when selected antigens are delivered in particulate form. This study investigated whether the mycobacterial antigen fusions H4 and H28 can induce protective immunity when assembled into particulate vaccines (polyester nanoparticle-H4, polyester nanoparticle-H28, H4 nanoparticles and H28 nanoparticles). The particulate mycobacterial vaccines were assembled inside an engineered endotoxin-free production strain of <i>Escherichia coli</i> at high yield. Vaccine nanoparticles were purified and induced long-lasting antigen-specific T cell responses and protective immunity in mice challenged by aerosol with virulent <i>Mycobacterium tuberculosis</i>. A significant reduction of <i>M. tuberculosis</i> CFU, up to 0.7-log<sub>10</sub> protection, occurred in the lungs of mice immunized with particulate vaccines in comparison to placebo-vaccinated mice (<i>p</i> < 0.0001). Polyester nanoparticles displaying the mycobacterial antigen fusion H4 induced a similar level of protective immunity in the lung when compared to <i>M. bovis</i> bacillus Calmette-Guérin (BCG), the currently approved TB vaccine. The safe and immunogenic polyester nanoparticle-H4 vaccine is a promising subunit vaccine candidate, as it can be cost-effectively manufactured and efficiently induces protection against TB.
Interplay of spinal and vagal pathways on esophageal acid-related anterior cingulate cortex functional networks in rats (2019)

Esophageal acid sensory signals are transmitted by both vagal and spinal pathways to the cerebral cortex. The influence and interplay of these pathways on esophageal acid-related functional connectivity has been elusive. Our aim was to evaluate the esophageal acid exposure-related effect on the anterior cingulate cortex (ACC) functional connectivity networks using functional MRI-guided functional connectivity MRI (fcMRI) analysis. We studied six Sprague-Dawley rats for fcMRI experiments under dexmedetomidine hydrochloride anesthesia. Each rat was scanned for 6 min before and after esophageal hydrochloric acid infusion (0.1 N, 0.2 ml/min). The protocol was repeated before and after bilateral cervical vagotomy on the same rat. Seed-based fcMRI analysis was used to examine ACC networks and acid-induced network alterations. Three-factor repeated-measures ANOVA analysis among all four subgroups revealed that the interaction of acid infusion and bilateral vagotomy was mainly detected in the hypothalamus, insula, left secondary somatosensory cortex, left parietal cortex, and right thalamus in the left ACC network. In the right ACC network, this interaction effect was detected in the caudate putamen, insula, motor, primary somatosensory cortex, secondary somatosensory cortex, and thalamic regions. These regions in the ACC networks showed decreased intranetwork connectivity due to acid infusion. However, after bilateral vagotomy, intranetwork connectivity strength inversed and became stronger following postvagotomy acid infusion. Signals transmitted through both the vagal nerve and spinal nerves play a role in esophageal acid-related functional connectivity of the ACC. The vagal signals appear to dampen the acid sensation-related functional connectivity of the ACC networks. <b>NEW & NOTEWORTHY</b> These studies show that esophageal acid-induced brain functional connectivity changes are vagally mediated and suggest that signals transmitted through both the vagal nerve and spinal nerves play a role in esophageal acid-related functional connectivity of the anterior cingulate cortex. This paper focuses on the development of a novel rat functional MRI model fostering improved understanding of acid-related esophageal disorders.
Cooling capacity and cost metrics for energy efficient workload placement in datacenters (2012)

Energy usage in the data centers has been increasing drastically in the recent years attracting many studies in power and thermal management in data centers. However, research has been focused mainly at power management of IT equipment and efficiently delivering cooling resources for a given IT load distribution. To further increase the energy efficiency of data centers, an integrated approach to preferentially placing IT load at locations of highest cooling efficiency is necessary. Such cooling aware workload placement can bring substantial savings when coupled with the migration of workload away from less cooling-efficient locations and the powering down of machines that are not in active use. Along with cooling-aware migration, it is critical to quantify the available cooling capacity and the cooling cost to support additional heat load at different locations in a datacenter to affect placement of new workload and, from a longer term point of view, for IT planning purposes. This paper presents novel thermal metrics which can be used to estimate available cooling capacities for different thermal zones in an operational datacenter. The thermal metrics also show the local distribution of the available cooling capacity at different racks within a thermal zone. The paper will also present another new metric called localized cooling cost which is utilized to rank locations with respect to costs incurred for cooling additional workload. We utilize CFD simulations for a case study showing application of the metrics.
Looking Forward in Pharmaceutical Process Chemistry (2009)

Core activities of process chemistry involve the synthesis of drug candidates at a scale that supports clinical evaluations and the creation of a manufacturing process that is safe, robust, and cost effective. Innovative problem solving has always been a key element in process chemistry and will be increasingly important for addressing emerging challenges in science, globalization, and commoditization. The acquisition and creation of platform chemical technologies that enable rapid problem solving through the use of high-throughput experimentation will continue to be an important focus going forward. Linking and deploying platforms throughout the discovery-development continuum is expected to enable drug discovery. Increasing collaboration with academia will also become more important for accessing technical solutions and providing the next generation of innovative problem solvers.
F6: Mixed-signal/RF design and modeling in next-generation CMOS (2013)

Technology awareness and modeling is important in all areas of mixed-signal and RF design. This forum intends to provide a holistic overview and discussion spanning a variety of important topics in device modeling, reliability and simulation in next-generation CMOS. It begins with an analog/RF-centric comparison between FinFET and ultra-thin-body SOI technology. The next two talks then venture into bias stress and Electrostatic Discharge Protection (ESD), which are two issues of ever-increasing importance for future scaling. The fourth presentation discusses the latest developments surrounding the popular BSIM transistor model, and explains how this new model can be efficiently coupled to the analog/RF design process. Motivated by their increasing significance in integrated RF transceivers, the next talk outlines a future roadmap for passive components in scaled technologies. Then, we expand upon modeling challenges that arise when components are stacked in three dimensions. Finally, this series of modeling talks is rounded up by two comprehensive presentations that summarize key challenges from the foundry and EDA tool vendor perspectives.
The Effects of Interleukin-6 on Tumor-Infiltrating Lymphocytes Derived from Human Renal Cell Cancer (1991)

Tumor-infiltrating lymphocytes (TIL) are a heterogeneous population of T cells with potent antitumor activity against a wide variety of tumors. TIL from renal cell cancer (RCC) typically exhibit diminished growth and antitumor activity after four weeks in vitro. We have therefore investigated effects of varying doses of interleukin-6 (IL-6) (0, 25, 100 units/ml.) on in vitro expansion, proliferation, cytotoxicity, and expression of cell surface phenotypes of long term renal TIL cultures from three RCC patients. Among the various conditions tested, three of three TIL cultures displayed a mild increase in cell expansion when grown in IL-2 with the addition of 100 units/ml. of IL-6. Two of three TIL cultures grown in IL-2 and 100 U/ml. of IL-6 demonstrated enhanced proliferation as determined by 3H-thymidine uptake. TIL could not be isolated or maintained in vitro when grown in the presence of IL-6 alone without IL-2. IL-6 was also found to enhance the long term non-specific cytotoxicity against an allogeneic nonrenal tumor target. No consistent effect on autologous tumor-specific cytotoxicity was demonstrated. We conclude that IL-6, when used in combination with IL-2, may modestly enhance the long-term growth of RCC-derived TIL.
Pedestrian Recognition Based on 24 GHz Radar Sensors (2013)

It is important to notice that this waveform is not processed by a matched filter or analyzed by an ambiguity function. Instead it is processed in a non-matched filter form to get an unambiguous and simultaneous target range and Doppler frequency measurement with