gebhart/patrepeval huggingface dataset:
Methods for Prediction of Gold Plating Characteristics by Numerical Analysis (2006)

Methods for prediction of gold plating characteristics by numerical analysis were investigated. The gold plating bath for the evaluation contains 5,5-dimethylhydantoin (DMH) as the complexing agent. HAuCl4 was used as the gold source, and phosphate salt was contained as a pH buffer. Thallium ion was added to refine the deposited grains. The concentration of Au([Au]), the pH, and the temperature were manipulated to determine the composition and conditions of the plating bath. The appearance of gold films was evaluated by color measurement using the L*a*b* color system. This method of evaluation is advantageous in terms of quantification of the appearance. Values of the color measurement tended to change depending on the various compositions and conditions of the plating bath. The brightness of the color L* obtained as a result of the color measurement was analyzed numerically with a statistical technique. The following experimental formulas were established by the numerical analysis.L*(−) = K0{1−exp(−K1C)}−K2CK0(−) = 73.9−2180exp(−0.125T)K1(M−1) = 178K2(M−1) = 338−323exp[−{(pH−7.18)/1.17}2][C : [Au] (M = mol/dm3), T : temperature(ºC)]
Abstract IA18: Fighting fire with fire: Developing a personalized neoantigen cancer vaccine (2015)

Abstract One of the critical steps to developing curative and tumor-specific immunotherapy is the identification and selection of antigens with tumor-restricted expression in order to avoid undesirable immune responses against normal tissues. Tumor neoantigens are analogous to non-self foreign proteins, therefore bypassing central tolerance and are also exquisitely tumor-specific. Seminal studies have provided compelling evidence suggesting their immunogenicity. However, the comprehensive identification of such neoantigens has only become feasible recently using next-generation massively-parallel sequencing technologies, providing unprecedented genetic information about cancer cells. In addition, refinements in class I HLA prediction algorithms, particularly NetMHCpan, have enabled the reliable prediction of peptide binding for a broad range of class I HLA alleles. Recent studies by us and others in humans and mice have leveraged these tools to demonstrate evidence of protective immunity when targeting tumor neoantigens. We have developed pipelines that leverage WES to systematically identify personal tumor mutations with immunogenic potential, which can be incorporated as antigen targets in a multi-epitope personalized therapeutic vaccine. We are pioneering this approach in a first-in-man clinical trial in melanoma. Citation Format: Catherine J. Wu. Fighting fire with fire: Developing a personalized neoantigen cancer vaccine. [abstract]. In: Proceedings of the AACR Special Conference: Tumor Immunology and Immunotherapy: A New Chapter; December 1-4, 2014; Orlando, FL. Philadelphia (PA): AACR; Cancer Immunol Res 2015;3(10 Suppl):Abstract nr IA18.
p38 MAPK signaling and phosphorylations in the BRCT1 domain regulate XRCC1 recruitment to sites of DNA damage (2017)

XRCC1 is a scaffold protein involved in base excision repair and single strand break repair. It is a phosphoprotein that contains more than 45 phosphorylation sites, however only a few of these have been characterized and connected to specific kinases and functions. Mitogen activated protein kinases (MAPK) are mediators of cellular stress responses, and here we demonstrate that p38 MAPK signaling is involved in phosphorylation of XRCC1 and regulation of recruitment to oxidative stress. Inhibition of p38 MAPK caused a marked pI shift of XRCC1 towards a less phosphorylated state. Inhibition of p38 also increased the immediate accumulation of XRCC1 at site of DNA damage in a poly(ADP)-ribose (PAR) dependent manner. These results suggest a link between PARylation, p38 signaling and XRCC1 recruitment to DNA damage. Additionally, we characterized two phosphorylation sites, T358 and T367, located within, or close to, the phosphate-binding pocket of XRCC1, which is important for interaction with PAR. Mutation of these sites impairs recruitment of XRCC1 to DNA damage and binding to PARP1/PAR. Collectively, our data suggest that phosphorylation of T358 and T367 and p38 signaling are important for proper regulation of XRCC1 recruitment to DNA damage and thereby avoidance of potential toxic and mutagenic BER-intermediates.
Mechanical Behaviour of Welded Joints Achieved by Multi-Wire Submerged Arc Welding (2017)

The paper addresses the development of advanced welding technologies with two and three solid wires for joining of HSLA API-5l X70 (High-strength low-alloy) steel plates with thickness of 19.1 mm. The experiments were performed using a multi-wire Submerged Arc Welding (SAW) system that was developed for welding of steels with solid, tubular and cold wires, in different combinations. The main goal of the research was to assess the mechanical performances of the welded joints achieved by multi-wire SAW technology and then to compare them with the single wire variant, as reference system. The welded samples were firstly subjected to NDT control by examinations with liquid penetrant, magnetic particle, ultrasonic and gamma radiation, with the aim of detecting the specimens with flaws and afterwards to reconsider and redesign the corresponding Welding Procedure Specifications (WPS). The defect-free welded samples were subjected to tensile, Charpy V-notch impact and bending testing in order to analyse and report the mechanical behaviour of API-5l X70 steel during multi-wire SAW process. The experimental results were processed and comparatively discussed. The challenge of the investigation was to find the appropriate welding technology which responds simultaneously to the criteria of quality and productivity. Further research on metallurgical behaviour of the base material will be developed, in order to conclude the complete image of the SAW process effects and to understand how the multi-wire technologies affect the mechanical and metallurgical characteristics of the API-5L X70 steel used in pipelines fabrication.
Development of the Control System Using EGR Gas for the HCCI Engine Running on DME (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
TAT‐BH4 counteracts Aβ toxicity on capillary endothelium (2007)

Oxidative stress is one of the factor contributing to blood brain barrier degeneration. This phenomenon is observed during pathological conditions such as Alzheimer's disease or cerebral amyloid angiopathy in which brain haemorrhages are very frequent. Both diseases are characterized by beta amyloid peptide deposition either in neurons or in vessels. Oxidative stress leads to impairment of mitochondrial functions and apoptotic cell death subsequent to caspases activation. In this paper we demonstrate that BH4 domain of Bcl-xl administrated to endothelial cells as the conjugated form with TAT peptide, reverts Abeta-induced apoptotic cell death by activating a survival programme which is Akt/endothelial nitric oxide synthase dependent.
A Visual Pattern of Mycotoxin Production in Maize Kernels byAspergillusspp. (1994)

Different Aspergillus species flavus, parasiticus, and nidulans), which produce different intermediates and end products of the aflatoxin pathway (norsolorinic acid, NOR; sterigmatocystin, ST; and aflatoxin, AF), are useful in studying the maize-Aspergillus-mycotoxin interaction. Aspergillus AF mutants, which produce NOR (a visible orange intermediate of both ST and AF), were used to visualize mycotoxin deposition in host and fungal tissues. NOR was seen in specific maize kernel tissues (embryo and aleurone) and specific fungal tissues (substrate mycelium but not sporulating mycelium) within 24 h after inoculation of kernels or growth media [...]
Concrete realization of the whole gamma imaging concept (2017)

PET is recognized as a successful method to pursue cancer diagnosis and molecular imaging. However, in order to meet emerging demands for widened imaging applications such as in-situ real-time single-cell tracking, we need to break through the principle of PET itself. In this paper, therefore, we propose a new concept of whole gamma imaging (WGI), which is a novel combination of PET and Compton imaging. An additional detector ring, which is used as the scatterer, is inserted in a conventional PET ring so that single gamma rays can be detected by the Compton imaging method. Therefore, in addition to Compton imaging (single-gamma mode), missing pairs of annihilation photons in PET, at least one of which is undetected, can be used for imaging (PET mode). Further large sensitivity gain can be expected for triple gamma emitters such as 44Sc, that emits a pair of 511 keV photons and a 1157 keV gamma ray almost at the same time (triple-gamma mode). In principle, only a single decay would be enough to localize the source position: (1) the coincidence detection of a pair of 511keV photons locates the source position along a line-of-response (LOR), and (2) the source position is identified as one of two intersection points of the LOR with a Compton cone after measuring the 1157 keV gamma ray. Using GEANT4, we simulated an “insert geometry”, in which a scatter ring (24 × 24 array of 1 × 1 × 6 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> GAGG crystals, 20 cm diameter and 5 cm long,) was inserted into a PET ring (16 × 16 × 4-DOI array of 2.9 × 2.9 × 7.5 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> GSOZ crystals, 66 cm diameter and 22 cm long). In the single-gamma mode, spatial resolution for the 511keV source obtained by 3D OSEM was 6.2 mm FWHM (center)-3.0 mm FWHM (8 cm off-center). In the triple-gamma mode, the position distribution of a <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">22</sup> Na point source projected on a line-of-response was 7.3 mm FWHM at the 5 cm off-center position without applying any image reconstruction. From the simulation results, we were able to develop the first prototype of the WGI system.
Afatinib ameliorates osteoclast differentiation and function through downregulation of RANK signaling pathways (2017)

Non-small-cell lung cancer (NSCLC) is the third most common cancer that spreads to the bone, resulting in osteolytic lesions caused by hyperactivation of osteoclasts. Activating mutations in epidermal growth factor receptor-tyrosine kinase (EGF-TK) are frequently associated with NSCLC, and afatinib is a first-line therapeutic drug, irreversibly targeting EGF-TK. However, the effects of afatinib on osteoclast differentiation and activation as well as the underlying mechanism remain unclear. In this study, afatinib significantly suppressed receptor activator of nuclear factor κB (RANK) ligand (RANKL)-induced osteoclast formation in bone marrow macrophages (BMMs). Consistently, afatinib inhibited the expression of osteoclast marker genes, whereas, it upregulated the expression of negative modulator genes. The bone resorbing activity of osteoclasts was also abrogated by afatinib. In addition, afatinib significantly inhibited RANKL-mediated Akt/protein kinase B and c-Jun N-terminal kinase phosphorylation. These results suggest that afatinib substantially suppresses osteoclastogenesis by downregulating RANK signaling pathways, and thus may reduce osteolysis after bone metastasis. [BMB Reports 2017; 50(3): 150-155].
CCDC 858796: Experimental Crystal Structure Determination (2012)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Lithography process related OPC development and verification demonstration on a sub-90nm poly layer (2005)

Using a commercialized product Calibre OPC platform, optical and process models were built that accurately predict wafer-level phenomena for a sub-90nm poly process. The model fidelity relative to nominal wafer data demonstrates excellent result, with EPE errors in the range of &plusmn;2nm for pitch features and &plusmn;7 for line-end features. Furthermore, these models accurately predict defocus and off-dose wafer data. Overlaying SEM images with model-predicted print images for critical structures shows that the models are stable and accurate, even in areas especially prone to pinching or bridging. In addition, process window ORC is shown to identify potential failure points within some representative designs, allowing the mask preparation shop to easily identify these areas within the fractured data. And finally, the data and images of mask hotspots will be shown and compared down to wafer level.
Megawatt single mode femtosecond erbium fiber laser (2021)

High power femtosecond fiber laser systems typically rely on self-similar amplification, large scale chirped pulse amplification (CPA), or higher-order soliton pulse compression. In any of these system architectures the control or minimization of fiber nonlinearities is paramount. To date, the scalability of Er fiber lasers in particular has been limited due to their intrinsic anomalous dispersion (limiting self-similar amplification) and their small gain bandwidth (limiting CPA) whereas higher-order soliton compression generally limits pulse quality. Here, we address these limitations by enabling highly nonlinear pulse propagation in Er fiber amplifiers with minimal pulse distortions based on adaptive control of the input pulse. Though the system is subject to high levels of self-phase modulation, the output pulse quality remains high, moreover, the output bandwidth is greatly increased, easily surpassing the bandwidth limitation of classical CPA systems. Adaptive control is enabled via a compact adaptive chirped fiber Bragg grating (FBG) pulse shaper/stretcher, paired with a matched, static FBG compressor. We generate 110 nJ pulses, with a FWHM of 62 fs in a single mode Er fiber amplification system at a repetition rate of 99.8 MHz, corresponding to an average power of 11.0 W. This corresponds to a maximum peak power of 1.4 MW, which should yield focused intensities above 1 TW/cm2, providing the high intensity and repetition rate needed to combine strong-field effects such as high harmonic generation in solids with the precision of frequency combs. At a lower 25 MHz repetition rate, we reach 340 nJ, 63 fs.
Stimulation of Transcriptional Regulatory Activity by Substance P (1994)

The neuropeptide substance P (SP) is one of the principal mediators of neurogenic inflammation as well as a neurotransmitter in nociceptive affect neurons. The mechanisms by which binding of SP to its receptor stimulates diverse downstream biologic effects remain unknown. In order to elucidate this process we have established stably transfected cell lines expressing functional rat SP receptors (KNRK-SPR). When stimulated by SP, KNRK-SPR cells respond by simultaneously mobilizing intracellular Ca2+ and increasing cAMP levels. To determine if SP stimulation activates downstream transcriptional regulatory factors, we transfected KNRK-SPR cells with plasmids containing the activator protein 1 (AP-1) and cAMP-responsive (CRE) enhancer elements coupled to the chloramphenicol acetyltransferase (CAT) reporter gene. Stimulation with SP 1-1,000 nM caused a 1.5- to 2-fold increase in CAT activity in both AP-1-CAT- and CRE-CAT-transfected KNRK-SPR cells. Northern and Western blot analyses demonstrate that the mechanism by which SP stimulates AP-1 enhancer activity involves increases in both c-jun mRNA and protein. Moreover, gel retardation assays with oligomers containing the AP-1 and CRE binding sites showed that SP induces specific retardation bands consistent with increases in AP-1 and CRE complexes. These experiments suggest that SP-mediated stimulation of cells involves the participation of two signaling pathways resulting in several transcriptional regulatory mechanisms being activated.
pClock (2007)

Storage consolidation is becoming an attractive paradigm for data organization because of the economies of sharing and the ease of centralized management. However, sharing of resources is viable only if applications can be isolated from each other. This work targets the problem of providing performance guarantees to an application irrespective of the behavior of other workloads. Application requirements are represented in terms of the average throughput, latency and maximum burst size. Most earlier schemes only do weighted bandwidth allocation; schemes that provide control of latency either cannot handle bursts or penalize applications for their own prior behavior, such as using spare capacity.
No Evidence of Myocardial Oxygen Deprivation in Nonischemic Heart Failure (2015)

Our results demonstrate dissociation between microvascular dysfunction and oxygenation in DCM, suggesting that the impairment of perfusion is not sufficient to cause deoxygenation during stress. Cardiac energetics are unaffected by oxygen supplementation, indicating the absence of relevant myocardial hypoxia at rest. Our study suggests that novel treatments for nonischemic heart failure should focus on efforts to directly target cardiomyocyte function and metabolism rather than oxygen delivery and microvascular function.
Extraction of guided modes from organic emission layers by compound binary gratings (2012)

The extraction of guided modes from a 100 nm organic emission layer by compound binary gratings with multiple superimposed periods at different ratios is investigated. We measure angle-dependent photoluminescence from samples with double-period (350 and 450 nm), triple-period (350, 400, and 450 nm), and multiperiod (350, 400, 450, and 500 nm) gratings and show that each period component produces two outcoupling features due to first-order Bragg scattering of the TE(0) guided mode. The averaged angular color change is reduced by up to a factor of 11 compared to a single-period grating structuring.
SATURATION AND SUBCOOLED CHF CORRELATIONS FOR PF-5060 DIELECTRIC LIQUID ON INCLINED ROUGH COPPER SURFACES (2014)

Pool-boiling experiments investigated the critical heat flux (CHF) for degassed PF-5060 dielectric liquid on inclined and uniformly heated 10×10 mm rough copper (Cu) surfaces. The experiments tested 13 surfaces with average roughness, Ra = 0.039 (smooth-polished), 0.134, 0.21, 0.28, 0.33, 0.58, 0.71, 0.80, 0.925, 1.00, 1.21, 1.44, and 1.79 μm, at inclination angles, θ = 0° (upward facing); 60°, 90° (vertical); and 120°, 150°, 160°, 170°, and 180° (downward facing). In addition, liquid subcooling in the experiments, ΔTsub, varied from 0 K (saturation) to 30 K. The CHF increased with increasing both surface roughness and liquid subcooling, but decreased with increasing inclination angle. For all inclinations, CHFsat on the roughest surface is ~35% higher than on the smoothpolished Cu. Moreover, regardless of Ra, CHFsat values in the downward facing orientation (180°) are typically ~31% of those in the upward facing orientation (0°). CHF in the upward facing orientation increases linearly with increasing liquid subcooling at a rate of ~2.2%/K, independent of Ra. This rate increases with increasing the inclination angle to as much as 4%/K in the downward facing orientation. The developed CHF correlation based on the present database accounts for surface roughness and inclination angle, and the liquid's subcooling and physical properties and agrees with the experimental data to within &pm;10%.
<title>Photoconductive measurements on P-type 6H-SiC</title> (1993)

The optoelectronic properties of 6-H silicon carbide (6H-SiC) were investigated using lateral and vertical photoconductive switches. We report the measurement of photovoltaic and photoconductive effects for both geometries and at several wavelengths near the 6H-SiC absorption edge. The carrier lifetime in p-type 6H-SiC is also reported. Although the devices possess dark resistances on the order of 10 (Omega) , the switching efficiency of the vertical switches approached 32 percent, while the resistance of the lateral devices could be reduced by 50 percent with 200 (mu) J of laser radiation at (lambda) equals 337 nm. In addition, we measured photoconductivity in the vertical switches with a device static powers dissipation exceeding 11 Watts. Although the device was glowing from the high level of dc power being dissipated, only the switch mount was damaged. 6H-SiC is indeed a high-temperature optoelectronic material.
Abstract 2456: Discovery of orally active 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes with dual EGFR and HER2 inhibitory activity. (2013)

Abstract Growth factor receptors of the ErbB family, especially ErbB1 (EGFR) and ErbB2 (HER2), have attracted considerable attention in recent years as therapeutic targets for the treatment of numerous malignancies including cancers of the lung, colon, and breast, either through blockade of the extracellular ligand binding site by monoclonal antibodies (e.g. anti-EGFR antibodies cetuximab and panitumumab, and anti-HER2 antibody trastuzumab) or inhibition of the intracellular tyrosine kinase domain by small molecule inhibitors (e.g. EGFR kinase inhibitors gefitinib and erlotinib, and dual EGFR/HER2 inhibitor lapatinib). The abundance of small molecule kinase inhibitors in clinical development or on the market attests to the acceptance of ErbB inhibition as a clinically relevant paradigm. Nevertheless, the emergence of resistance mechanisms in ErbB driven or dependent tumors indicates that continued research is required to discover more effective drugs. We previously reported the discovery of JNJ-28871063, a potent inhibitor of EGFR and HER2 kinases in vitro that also showed excellent antitumor efficacy in EGFR (A431 epidermoid carcinoma) and HER2 (N87 gastric carcinoma) overexpressing xenograft models and significant extension of survival in a mouse intracranial tumor model. This compound is a 4-amino-6-arylaminopyrimidine-5-carbaldehyde oxime, a monocyclic chemotype that mimics the traditional bicyclic quinazoline scaffold via an intramolecular hydrogen-bonded pseudocycle involving the adjacent 4-amino and 5-oximino groups. In this study, we present results of a structure-guided analog program designed to optimize in vitro kinase potency and in vivo antitumor efficacy of the pyrimidine-oximes. While substituents on the 6-arylamino group are critical for ErbB inhibitory potency and kinase selectivity, substitution on the oxime oxygen may be changed to modify physico-chemical properties and bioavailability. We will discuss structure-activity relationships for the 5-oximino and 6-arylamino groups as well as the important role played by O-aminoalkyl oxime substituents in improving in vivo activity. Citation Format: Peter J. Connolly, Mary Adams, Amanda K. Beck, Stuart L. Emanuel, Angel R. Fuentes-Pesquera, Lee M. Greenberger, Robert H. Gruninger, Terry V. Hughes, Stephen A. Middleton, Sandra Moreno-Mazza, Niranjan Pandey, Steven K. Wetter, Guozhang Xu. Discovery of orally active 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes with dual EGFR and HER2 inhibitory activity. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2456. doi:10.1158/1538-7445.AM2013-2456