gebhart/patrepeval huggingface dataset:
Treatment of Degenerated Intervertebral Discs using a Viable Disc Tissue Allograft for Chronic Discogenic Low Back Pain: A Randomized Controlled Trial Comparing Single-Site Outcomes with Aggregate and Longer-term Follow-Up Data (2021)

Abstract BackgroundDisruption of the internal structure of the nucleus pulposus commonly occurs with the development of painful degenerative lumbar disc disease. Supplementing disc tissue through autologous or allogeneic human cellular and tissue therapies has been tested in small sample clinical trials. A few investigators have reported substantial improvements in pain and function. A viable disc tissue allograft was developed to supplement tissue loss associated with intervertebral disc degeneration. MethodsWe assessed results in a subgroup of patients from a large trial comparing this allograft with other treatments. A multicenter randomized controlled trial of 218 subjects with chronic low back pain secondary to degenerative disc disease was conducted. Patients were treated with the allograft, saline, or nonsurgical management and studied for 12 months. We assessed longer-term results in a single-site subgroup from this prospective trial.ResultsAt 12 months, subjects from the single-site subgroup who had been randomly assigned to the active allograft group (n=17) showed improvements in both mean Oswestry Disability Index (ODI) and Visual Analog Scale (VAS) scores. There was an overall reduction of 28.69 points in the ODI and 33.06 points in the VAS. This was similar to the aggregate ODI and VAS scores of the active allograft group. At 24 months postprocedure, 9 of the 10 patients remaining in the active allograft group at the single study site had mean ODI and VAS score improvements of 28.23 and 36.13, respectively. A similar improvement in pain scores occurred in the 4 patients at 36 months with mean ODI and VAS score improvements from preoperative scores of 25.21 and 51.35, respectively.ConclusionsClinically meaningful improvements demonstrated in this single-site analysis were comparable to the aggregate study population at 12 months. Longer-term results from this single site at 24 and 36 months suggested durability of viable disc tissue allograft supplementation for patients with discogenic back pain.Trial registration﻿The trial was retrospectively registered 17 October 2018 on www.clinicaltrials.gov (NCT03709901) and was approved by the Sterling Institutional Review Board, Atlanta, Georgia (IRB no. 5792).
Design Considerations of Dedicated and Aerial 5G Networks for Enhanced Positioning Services (2022)

Dedicated and aerial fifth generation (5G) networks, here called 5G overlay networks, are envisaged to enhance existing positioning services, when combined with global navigation satellite systems (GNSS) and other sensors. There is a need for accurate and timely positioning in safety-critical automotive and aerial applications, such as advanced warning systems or in urban air mobility (UAM). Today, these high-accuracy demands can partially be satisfied by GNSS, though not in dense urban conditions or under GNSS threats (e.g. interference, jamming or spoofing). Temporary and on-demand 5G network deployments using ground and flying base stations (BSs) are indeed a novel solution to exploit hybrid GNSS, 5G and sensor algorithms for the provision of accurate three-dimensional (3D) position and motion information, especially for challenging urban and suburban scenarios. Thus, this paper first analyzes the positioning technologies available, including signals, positioning methods, algorithms and architectures. Then, design considerations of 5G overlay networks are discussed, by including simulation results on the 5G signal bandwidth, antenna array and network deployment.
C1q/Tumor Necrosis Factor-Related Protein 9 Protects against Acute Myocardial Injury through an Adiponectin Receptor I-AMPK-Dependent Mechanism (2015)

Obesity is a risk factor for cardiovascular disease. C1q/tumor necrosis factor-related protein 9 (CTRP9) is an adipokine that is downregulated by obesity. We investigated the role of CTRP9 in cardiac injury with loss-of-function genetic manipulations and defined the receptor-mediated signaling pathway downstream of this adipokine. CTRP9-knockout (CTRP9-KO) mice at the age of 12 weeks were indistinguishable from wild-type (WT) mice under basal conditions. CTRP9-KO mice had exacerbated contractile left ventricle dysfunction following intraperitoneal injection of lipopolysaccharide (LPS) compared to WT mice. Administration of LPS to CTRP9-KO mice also resulted in increased expression of proinflammatory cytokines and oxidative stress markers in the heart compared to WT mice. Likewise, CTRP9-KO mice showed increased myocardial infarct size and elevated expression of inflammatory mediators in ischemic heart following ischemia and reperfusion compared to WT mice. Treatment of cardiac myocytes with CTRP9 protein led to suppression of LPS-induced expression of proinflammatory genes, which was reversed by blockade of AMPK or ablation of adiponectin receptor I (AdipoR1). Systemic delivery of CTRP9 attenuated LPS-induced cardiac dysfunction in WT mice but not in muscle-specific transgenic mice expressing dominant-negative mutant form of AMPK or in AdipoR1-knockout mice. CTRP9 protects against acute cardiac damage in response to pathological stimuli by suppressing inflammatory reactions through AdipoR1/AMPK-dependent mechanisms.
Pathogenic potential of fiftyBacillus weihenstephanensisstrains (2002)

The aim of this study was to evaluate the food poisoning potential of strains of the new species in the Bacillus cereus group, B. weihenstephanensis. Fifty strains were tested for cytotoxicity in a Vero cell assay, and 23 of the strains were also tested for production of enterotoxin components with commercial antibody kits, and for presence of enterotoxin gene components by polymerase chain reaction (PCR). The majority of the strains (72%) were not cytotoxic, although all of the strains that were tested with PCR and commercial kits had part of at least one of the B. cereus enterotoxins Hbl, Nhe or CytK.
Nanosession: Advanced Spectroscopy and Scattering (2012)

Engineering interfaces between complex oxides has proven to be a powerful technique for tuning their electronic and magnetic properties. This chapter shows that the valence band offsets (VBO) result for two multilayers (SrTiO3/LaNiO3)x10 and (SrTiO3/GdTiO3)x20 determined by SXPS ( hv=833eV) and HXPS (hv=5950 eV). Strontiumtitanate (SrTiO3) is a promising material for future use in oxide electronics due to the intrinsic electronic properties. The chapter presents the first experimental data for hard x-ray angle-resolved photoemission spectroscopy (HARPES) at energies of 3.2 and 6.0 keV. Photoelectron spectroscopy with HAXPES has been proven to reach probing depths of more than 15 nm. The chapter demonstrates the feasability of imaging at high kinetic energies at a reasonable spatial resolution as well as spatially resolved spectra from buried layers. The JCNS has installed the new, high-intensity reflectometer MARIA in the neutron guide hall of the FRM II reactor in Garching. Controlled Vocabulary Terms buried layers; strontium compounds; valence bands; X-ray spectroscopy
Random access camera (2002)

The authors describe an optical system that allows for the bit reversed decimation of an image scene. The optical system consists of a successive sequence of lens arrays. The output of one lens array feeds into the input of the next array. The function of each lens array is to divide the input into its four quadrants. The output of each array is the image formed by summing together the four quadrant images. The goal of this work is to design an optical front end for an imaging system that allows for the simultaneous imaging of both a wide angle field of view and a zoomed telephoto field of view. In addition optimized image acquisition is required for target tracking.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Relation of Undergraduate Leadership Educators’ Perceived Learning Goals and Use of Instructional Strategies (2012)

Students in leadership education are taught that leadership can be learned through practice, which stresses learning by doing (Komives, Lucas, &amp;amp; McMahon, 2007). Eison and Bonwell (1991) echoed this sentiment in their affirmation of active learning, defined as involving students
Influence of prior Na+pump activity on pump and Na+/Ca2+exchange currents in mouse ventricular myocytes (1998)

We examined the dependence of peak Na+ pump and Na+/Ca2+ exchanger currents on prior Na+ pump inhibition induced by exposure to zero extracellular K+ in voltage-clamped adult murine ventricular myocytes. Abrupt activation of the Na+ pump by reexposure of myocytes to extracellular K+ with a rapid solution switcher resulted in the development of a transient peak current at approximately 500 ms, followed by a decline over 1-2 min to a steady-state level. The magnitudes of both the peak Na+ pump current (Ip) and the peak outward Na+/Ca2+ exchange current, activated by rapidly reducing extracellular Na+ to zero with the solution switcher, were dependent on previous Na+ pump activity. [Na+] gradients (Na+-binding benzofuran isophthalate fluorescence) between the patch pipette and the bulk cytosol were relatively small and could not account for the large differences between peak and steady-state Ip and reverse Na+/Ca2+ exchanger currents. Our results are consistent with the presence of a subsarcolemmal Na+ concentration gradient, which is similar for the Na+ pump and the Na+/Ca2+ exchanger. These findings also support the hypothesis that the Na+ pump and the Na+/Ca2+ exchanger are colocalized in the sarcolemma.
Survivable mapping algorithm by ring trimming (SMART) for large IP-over-WDM networks (2004)

We develop a fast and efficient algorithm that finds a survivable (i.e., robust to single fiber failures) mapping of IP topology on the mesh of fibers in IP-over-WDM networks; we call it SMART. A number of algorithms solving this problem can be found in the literature. Since ILP solutions are highly complex, many heuristics were proposed. They usually start with some initial mapping and then try to gradually improve it. This involves the evaluation of the entire topology at each iteration, which is costly for large topologies. We propose a different approach. The SMART algorithm breaks down the task into a set of independent and very simple subtasks. The combination of solutions of these subtasks is a survivable mapping. This is why SMART is orders of magnitude faster than other proposals, especially when dealing with large topologies. We also extend the SMART algorithm to obtain a mapping resilient to fiber span failures, node failures and double-link failures. Finally, we show that the scalability of the standard heuristic approaches is additionally limited (contrary to SMART) when applied to double-link failures.
Atitudes, Conhecimentos e Perspetivas dos Médicos Portugueses acerca das Terapêuticas Não Convencionais: Um Estudo Transversal (2022)

Portuguese doctors seem to have a low level of knowledge about complementary and alternative medicine, and a relevantpart of them does not feel prepared to advise their patients about it.
Front Matter: Volume 9751 (2016)

This PDF file contains the front matter associated with SPIE Proceedings Volume 9751, including the Title Page, Copyright information, Table of Contents, Introduction (if any), and Conference Committee listing.
Li Diffusivity and Phase Change in LiFe0.5Mn0.5PO4: AComparative Study using Galvanostatic Intermittent Titrationand Cyclic Voltammetry (2011)

Lithium transport and phase evolution in the LiFe0.5Mn0.5PO4 system was examined using both cyclic voltammetry and galvanostatic intermittent titration. Hydrothermal or sol–gel processing was used to synthesize LiFe0.5Mn0.5PO4, LiFePO4, and LiMnPO4, and electrodes made with LiFe0.5Mn0.5PO4 or a 1:1 mass ratio of LiFePO4 and LiMnPO4 were produced and studied. Cyclic voltammetry was used to distinguish single- and dual-phase redox reaction regimes and also accurately measure ionic diffusivity in the dual redox couple LiFe0.5Mn0.5PO4 system. Ionic diffusivity values extracted from galvanostatic intermittent titration data were compared to those determined via cyclic voltammetry.These results are discussed in the context of theories that explain phase transitions and diffusion in this class of materials.
Transcriptomic and proteomic profiling of two porcine tissues using high-throughput technologies (2009)

We show that the reproducibility within cDNA microarray and 454-sequencing is high, but that the agreement across these two technologies is modest. We demonstrate that the regulation of transcript and protein levels across identical tissue samples is positively correlated when the tissue expression ratios are used for comparison. The results presented are of interest in systems biology research in terms of integration and analysis of high-throughput expression data from mammalian tissues.
Investigation of the misalignment of a resonator with a telescopic angular selector in a photodissociation laser (1976)

An experimental investigation was made of the characteristic features of the emission of a photodissociation laser with a resonator containing a telescopic angular selector. A method for aligning this resonator was developed and a study was made of the influence of misalignment of each of the resonator elements. The energy losses were found to correspond to the losses in the equivalent plane-parallel resonator. The advantages of the resonator employed was the maintenance of the angular width and direction of the maximum in the spatial distribution when a wedge deformation appeared in the resonator. The axial brightness was considerably higher than in the equivalent misaligned plane-parallel resonator without a selector.
Comparing nonrigid registration techniques for motion corrected MR prostate diffusion imaging (2014)

The authors' results show that the "fast elastic image registration" provides most accurate results with a target registration error of 1.07 ± 0.41 mm at minimum execution times of 11 ± 1 s.
Smooth eye-movement control with secondary visual feedback (1984)

A signal derived from continuous measurement of eye position is displayed on a visual frame of reference, thereby closing a secondary visual feedback (2VFB) loop. The distance between a target and the displayed gaze point provides the subject with an extra, artificial position error. Experiments show that subjects can use the 2VFB to generate smooth eye movements, even in the absence of any smoothly moving independent targets. Under these conditions, both direction and velocity can be brought under voluntary control by the subjects. As a control signal for the smooth-eye-movement mode, the 2VFB is robust and easily manipulated and provides an attractive means for the investigation of the smooth-movement control system in a variety of tasks and under different conditions.
Effect of Rail Dimensions on Rail Gun Design Parameters (2006)

The purpose of modeling the rail gun is to provide a theoretical understanding of how the design parameters of rail gun such as magnetic flux density between the rails, maximum current density over the rail cross section, repulsive force acting on the rail, and inductance gradient of the rail react under different conditions like the boundary conditions and variation in dimensions. Finite element analysis technique is employed to calculate the rail gun design parameters using two-dimensional analysis. The rail gun design parameters mainly depend on rails and armature, geometry and dimensions. This paper investigates how the rail dimensions affect the rail gun design parameters using finite element technique.
Increasing Molecular Weight of a Helical Polymer through Polymerization in a Chiral Solvent (2006)

Employing limonene as a chiral, nonracemic solvent has a marked effect upon the molecular weight of the product obtained by Wurtz polymerization of dichloromethylphenyl­silane. The high-molecular-weight fraction of the MW distribution increased when the reaction was carried out in enantioenriched, rather than racemic, limonene. Circular dichroism and UV-Vis spectroscopy indicated that polymethylphenylsilane, which adopts a helical conformation, exhibits a helix-sense excess when dissolved in enantio­enriched limonene.
Phase Purity and Luminescence Properties of Fine Ca-α-SiAlON:Eu Phosphors Synthesized by Gas Reduction Nitridation Method (2008)

This paper reports a simple, inexpensive, and efficient synthetic route to -based yellow phosphors for white light-emitting diodes. Through direct gas reduction and nitridation of the homogeneous oxide precursor of , fine phosphors were obtained by one-step firing at for 4 h in the flowing and mixture gas. The dependence of the structural characterization and optical properties on the overall composition of the host lattice has been investigated. A nearly single-phase can be synthesized by controlling the overall composition of the host lattice at and . The strongest luminescence is achieved at about and . Further improvement of the powder characteristics was attained by post heat-treatment at for 2 h under 5 atm of by gas-pressure sintering. The post-treated powders showed a pure phase at . The phosphor exhibits a high crystallinity, high luminescence intensity, high quantum efficiency, and very low thermal quenching, which is better than those prepared by the conventional solid-state reaction.
PTEN in antigen presenting cells is a master regulator for Th17-mediated autoimmune pathology (2012)

Rheumatology has pioneered in the study of autoantibodies by showing that they are not only involved in pathogenesis but are also highly useful as diagnostic biomarkers. The diagnostic biomarker aspect of autoimmunity has gained increasing importance in cancer and many of the insights gained in Rheumatology have contributed to understanding the significance of autoantibodies in cancer. Features of autoantibodies in rheumatic disorders: In rheumatic diseases no individual autoantibody-antigen system has sufficient combination of sensitivity and specificity to serve as a useful diagnostic biomarker. Instead, several antigen-antibody systems constructed as profiles of biomarkers are highly effective in distinguishing one disorder from another. In lupus, anti-double strand DNA and anti-Sm distinguishes it from scleroderma, where the profile is anti-DNA topoisomerase 1 and anti-centromere proteins. The autoantigensare cell components involved in universal and basic gene expression pathways, such as Sm in precursor mRNA splicing and DNA topoisomerase 1 in DNA replication and transcription [1]. Features of autoantibodies in cancer: Autoantibodies in cancer target intracellular molecules referred to as TAAs (tumor-associated antigens). As in rheumatic disorders, no individual autoantibody-antigen system has sensitivity and specificity to serve as a stand-alone diagnostic marker [2]. Most tumors show multiple antibody specificities and with panels of TAAanti-TAAs (analogous toprofiles) the cumulative sensitivity and specificity reaches diagnostic significance. Different tumorigenesis pathways are
Interdependence Between Geology and Well Test Interpretation (1991)

ABSTRACT This paper shows the leading role of geology in the choice of a well test interpretation model and in the selection of the best solution; at the same time the results coming from well test interpretation contribute to improve the geological model. Three field cases are discussed: The first case evidences the need of a good sedimentological analysis, in order to choose among the different reservoir models that match properly the derivative plot: Radial Composite, Homogeneous with two parallel or three boundaries. Geology indicates that the reservoir was deposited in the median part of a deep-sea fan, and that the perforated interval belongs to a channel layer. The model retained is therefore the homogeneous reservoir with two parallel boundaries, which gives a channel width of about 400 meters, in accordance with sedimentology.The second case deals with a shaly formation with few sandbodies. Regional geological knowledge allows to divide this formation into two main units with different sandstone sedimentological origin: fluvial or lacustrin. Interpretation of the well tests performed in the different sandbodies emphasizes the differences between the two sedimentological units, and allows to locate their limitIn the case of the fractured reservoir some input parameters were affected by a high degree of incertitude, and interpretation led to a too big range of possible values for the output parameters (permeability, vertical permeability anisotropy). Geological studies allow to decrease the incertitudes. A multidisciplinary approach with repeated information exchanges between geologist and reservoir engineer seems to be the best way to deal with well test interpretation problems.
Penile Fracture with Associated Urethral Rupture (2010)

Penile fracture of the erect penis is an uncommon but emergent urological trauma. Potential outcomes include erectile dysfunction, penile curvature, and urethral injury. Treatment is emergent surgical repair. We present the case of a 42-year-old man with a penile fracture complicated by a urethral rupture and subsequent repair. A discussion of the key aspects of this condition is presented.
Not All Antigens Are Created Equally: Progress, Challenges, and Lessons Associated with Developing a Vaccine for Leishmaniasis (2017)

From experimental models and the analyses of patients, it is well documented that antigen-specific T cells are critical for protection against <i>Leishmania</i> infection. Effective vaccines require both targeting to the pathogen and an immune stimulant to induce maturation of appropriate immune responses. While a great number of antigens have been examined as vaccine candidates against various <i>Leishmania</i> species, few have advanced to human or canine clinical trials. With emphasis on antigen expression, in this minireview we discuss some of the vaccine platforms that are currently being explored for the development of <i>Leishmania</i> vaccines. It is clear that the vaccine platform of choice can have a significant impact upon the level of protection induced by particular antigens, and we provide and highlight some examples for which the vaccine system used has impacted the protective efficacy imparted.
Design and influence factor analysis of CNTs'embedding microstructure model for CNTs/Al_2O_3 composites (2008)

To improve the reinforcing effect,a CNTs' embedding microstructure model for CNTs/Al2O3 composites was suggested. SWNTs/Al2O3,MWNTs/Al2O3 and aligned MWNTs/Al2O3 with this kind of microstructure were synthesized by heterocoagulation.Based on the microstructure and properties analysis,it has been found that the type,morphology and dispersibility of CNTs influence greatly the forming of CNTs' embedding microstructure model.The thin and straight SWNTs are advantageous to the forming of CNTs' embedding microstructure model.