gebhart/patrepeval huggingface dataset:
Comparative Analysis Of Two Approaches To Joint Signal Detection, Toa And Aoa Estimation In Multi-Element Antenna Arrays (2014)

In this paper two approaches to joint signal detection,<br> time of arrival (ToA) and angle of arrival (AoA) estimation in<br> multi-element antenna array are investigated. Two scenarios were<br> considered: first one, when the waveform of the useful signal<br> is known a priori and, second one, when the waveform of the<br> desired signal is unknown. For first scenario, the antenna array<br> signal processing based on multi-element matched filtering (MF)<br> with the following non-coherent detection scheme and maximum<br> likelihood (ML) parameter estimation blocks is exploited. For second<br> scenario, the signal processing based on the antenna array elements<br> covariance matrix estimation with the following eigenvector analysis<br> and ML parameter estimation blocks is applied. The performance<br> characteristics of both signal processing schemes are thoroughly<br> investigated and compared for different useful signals and noise<br> parameters.
Formation and reduction of pyramidal hillocks on InGaAs/InP(111)A (2015)

The formation and reduction of pyramidal hillocks on InGaAs/InP(111)A grown by metal organic chemical vapor deposition were investigated. The triangular pyramidal hillocks were observed on the InGaAs surface on on-axis InP (111)A grown at 650 °C. The hillocks disappeared when the vicinal InP (111)A substrates with an off-axis angle >0.4° were applied. The step and terrace surface of InGaAs on 4.0°-off InP (111)A were obtained. InGaAs on on-axis InP (111)A exhibited a hole concentration, mobility of Hall effect measurement, and full width at half-maximum of X-ray diffraction as 1.0 × 1017 cm−3, 56 cm2/V s, and 140 arcsec, respectively. In contrast, InGaAs on 2.0°-off InP (111)A exhibited 2.3–1017 cm−3, 142 cm2/V s, and 63 arcsec, respectively. We suggest that off-axis substrates enable a reduction of stacking faults, which leads to considerable improvement of crystallinity.
BamQuery: A new proteogenomic tool to explore the immunopeptidome and validate tumor‐specific antigens (2021)

peer reviewed
Transcatheter Aortic Valve Implantation for Severe Pure Aortic Regurgitation with Dedicated Devices (2022)

Aortic regurgitation (AR) is not the most common valvular disease; however, its prevalence increases with age, with more than 2% of those aged >70 years having at least moderate AR. Once symptoms related to AR develop, the prognosis becomes poor. Transcatheter aortic valve implantation for patients with pure severe AR and at prohibitive surgical risk is occasionally performed, but remains a clinical challenge due to absence of valvular calcium, large aortic root and increased stroke volume. These issues make the positioning and deployment of transcatheter aortic valve implantation devices unpredictable, with a tendency to prosthesis embolisation or malposition. To date, the only two dedicated transcatheter valves for AR are the J-Valve (JC Medical) and the JenaValve (JenaValve Technology). Both devices have been used successfully via the transapical approach. The transfemoral experience is limited to first-in-human publications and to a clinical trial dedicated to AR, for which the completion date is still pending.
(2R,3R,4R)-Methyl 2-bromo-3,4-dihydroxy-3,4-O-isopropylidenetetrahydrofuran-2-carboxylate (2005)

The relative configuration of the quaternary C atom in the title bromide, C9H13BrO5, prepared by bromination of the parent ester, has been determined by X-ray crystallographic analysis; the absolute configuration is known from the synthesis.
Low-Field Nuclear Magnetic Resonance Relaxation Study of Stored or Processed Cod (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLow-Field Nuclear Magnetic Resonance Relaxation Study of Stored or Processed CodPierre Lambelet, Francine Renevey, Carine Kaabi, and Aloies RaemyCite this: J. Agric. Food Chem. 1995, 43, 6, 1462–1466Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/jf00054a009https://doi.org/10.1021/jf00054a009research-articleACS PublicationsRequest reuse permissionsArticle Views153Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Measurements of Quantum Hamiltonians with Locally-Biased Classical Shadows (2020)

Obtaining precise estimates of quantum observables is a crucial step of variational quantum algorithms. We consider the problem of estimating expectation values of molecular Hamiltonians, obtained on states prepared on a quantum computer. We propose a novel estimator for this task, which is locally optimised with knowledge of the Hamiltonian and a classical approximation to the underlying quantum state. Our estimator is based on the concept of classical shadows of a quantum state, and has the important property of not adding to the circuit depth for the state preparation. We test its performance numerically for molecular Hamiltonians of increasing size, finding a sizable reduction in variance with respect to current measurement protocols that do not increase circuit depths.
Molekulardrucken mit auslegerlosen Rastersondentechniken (2011)

25 bzw. 30 Jahre nach der Erfindung der Rasterkraft- und Rastersondenmikroskopie markieren auslegerlose Rastersondenlithographietechniken wie die Polymerstiftlithographie (siehe Bild) eine wichtige Stufe in der Entwicklung von Molekulardrucktechniken. Mit diesen einfachen, robusten und preiswerten Methoden können nahezu beliebige nano- und mikroskalige Strukturen organischer und anorganischer Materialien auf Oberflächen erzeugt werden.
Integrated reluctance position sensor for the self-commutation of a hybrid linear electric actuator (2015)

International audience
High-Fat Diet–Induced Obesity Enhances Allograft Rejection (2016)

Our results highlight the increased alloresponse triggered by HFD-induced obesity and its negative impact on transplant outcome.
Antigen and substrate withdrawal in the management of autoimmune thrombotic disorders (2012)

Prevailing approaches to manage autoimmune thrombotic disorders, such as heparin-induced thrombocytopenia, antiphospholipid syndrome and thrombotic thrombocytopenic purpura, include immunosuppression and systemic anticoagulation, though neither provides optimal outcome for many patients. A different approach is suggested by the concurrence of autoantibodies and their antigenic targets in the absence of clinical disease, such as platelet factor 4 in heparin-induced thrombocytopenia and β(2)-glycoprotein-I (β(2)GPI) in antiphospholipid syndrome. The presence of autoantibodies in the absence of disease suggests that conformational changes or other alterations in endogenous protein autoantigens are required for recognition by pathogenic autoantibodies. In thrombotic thrombocytopenic purpura, the clinical impact of ADAMTS13 deficiency caused by autoantibodies likely depends on the balance between residual antigen, that is, enzyme activity, and demand imposed by local genesis of ultralarge multimers of von Willebrand factor. A corollary of these concepts is that disrupting platelet factor 4 and β(2)GPI conformation (or ultralarge multimer of von Willebrand factor oligomerization or function) might provide a disease-targeted approach to prevent thrombosis without systemic anticoagulation or immunosuppression. Validation of this approach requires a deeper understanding of how seemingly normal host proteins become antigenic or undergo changes that increase antibody avidity, and how they can be altered to retain adaptive functions while shedding epitopes prone to elicit harmful autoimmunity.
Single pole‐to‐ground fault location method for MMC‐HVDC system using active pulse (2017)

Modular multilevel converter HVDC (MMC‐HVDC) systems have been commissioned in China, America and Europe. With the demand of long‐distance and large‐capacity power transmission, the MMC‐HVDC systems using overhead lines get more attention. When a single pole‐to‐ground permanent fault occurs, the fault current is very small, therefore if the fault location is determined, the fault can be cleared and the HVDC system can revert to normal operation without interruption. MMC‐HVDC can quickly control the work state of sub‐modules (SMs), therefore, it is possible to generate travelling wave pulses propagating to the line by controlling SM, without the need of additional equipment. So in this study, a fault location method for MMC‐HVDC using active pulse is proposed. Meanwhile dichotomising recursion singular value decomposition is used to detect the arrival time of active pulse. The proposed method does not require additional equipment and the method is not influenced by transition resistance. And fault location can be repeated since the pulse can be sent repeatedly. Computer simulations are performed and the results show that the proposed method can locate the grounding point of MMC‐HVDC reliably and with increased accuracy relative to existing methods.
Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit (1993)

Tyrosine-phosphorylated peptides based on the regions of polyoma virus middle t antigen and the platelet-derived growth factor receptor that bind phosphoinositide 3-kinase are shown to activate this enzyme 2-3-fold in vitro. The concentrations of the peptides required to activate the enzyme are at least 10-1000-fold higher than the dissociation constants of these peptides for the individual SH2 domains of the 85-kDa subunit (KD < 100 nM). Doubly phosphorylated peptides are more effective than singly phosphorylated peptides. The results suggest that a fraction of the cellular phosphoinositide 3-kinase has SH2 domains with relatively low affinity for phosphopeptides and that binding of phosphopeptides to these enzymes causes activation. Thus, SH2 domains may be involved not only in recruiting the enzyme but also in regulating activity.
Magnetic force microscopy study of magnetic stripe domains in sputter deposited Permalloy thin films (2008)

A magnetic force microscopy based study on the formation of stripe domains in Permalloy (Ni80Fe20) thin films is presented. Our results show that the critical thickness for stripe domain initiation depended on the sputtering rate, the substrate temperature, and the film thickness. Beyond the stripe domain formation, an increase of the period of a highly ordered array of stripe domains was evident with increasing film thickness. Thin films sputtered at room temperature with thickness variation between ∼80 and ∼350nm exhibited square-root growth dependency on stripe domains periodicity from ∼150to∼380nm, respectively. Above a certain thickness, the domain period decreased and the periodicity deteriorated with the array becoming more random, which is a strong indicator of relatively high structural perpendicular anisotropy. To illustrate, Permalloy sputtered at 100°C initially showed linear dependence in stripe domain periodicity growth up until ∼650nm thick films. The magnetic stripe domain structure began breaking down for thicker Permalloy films. Our data also suggested that the perpendicular anisotropy responsible for the formation of stripe domains might have resulted from strain-caused magnetostriction and the thin-film microstructure shape effect.
Automated Synthesis and Optimization of Robot Configurations (1998)

Abstract We present an extensible system for synthesizing and optimizing robot configurations. The system uses a flexible representation for robot configurations based on parameterized modules; this allows us to synthesize mobile and fixed-base robots, including robots with multiple or branching manipulators and free-flying robots. Synthesis of modular robots is also possible with our representation. We use an optimization algorithm based on genetic programming. A distributed architecture is used to spread heavy computational loads across multiple workstations. We take a task-oriented approach to synthesis in which robots are evaluated on a designer-specified task in simulation; flexible planning and control algorithms are thus required so that a wide variety of robots can be evaluated. Our system’s extensibility stems from an object-oriented software architecture that allows new modules, metrics, controllers, and tasks to be easily added. We present two example synthesis tasks: synthesis of a robotic material handler, and synthesis of an antenna pointing system for a mobile robot. We analyze several key issues raised by the experiments and show several important ways in which the system can be extended and improved.
Single-cell recording and stimulation with a 16k micro-nail electrode array integrated on a 0.18 μm CMOS chip (2012)

To cope with the growing needs in research towards the understanding of cellular function and network dynamics, advanced micro-electrode arrays (MEAs) based on integrated complementary metal oxide semiconductor (CMOS) circuits have been increasingly reported. Although such arrays contain a large number of sensors for recording and/or stimulation, the size of the electrodes on these chips are often larger than a typical mammalian cell. Therefore, true single-cell recording and stimulation remains challenging. Single-cell resolution can be obtained by decreasing the size of the electrodes, which inherently increases the characteristic impedance and noise. Here, we present an array of 16,384 active sensors monolithically integrated on chip, realized in 0.18 μm CMOS technology for recording and stimulation of individual cells. Successful recording of electrical activity of cardiac cells with the chip, validated with intracellular whole-cell patch clamp recordings are presented, illustrating single-cell readout capability. Further, by applying a single-electrode stimulation protocol, we could pace individual cardiac cells, demonstrating single-cell addressability. This novel electrode array could help pave the way towards solving complex interactions of mammalian cellular networks.
Training-Based Equivalence Relations in Large-Scale Quantized Communication Systems (2020)

We show that a quantized large-scale system with unknown parameters and training signals can be analyzed by examining an equivalent system with known parameters by modifying the signal power and noise variance in a prescribed manner. Applications to training in wireless communications and signal processing are shown. In wireless communications, we show that the optimal number of training signals can be significantly smaller than the number of transmitting elements. Similar conclusions can be drawn when considering the symbol error rate in signal processing applications, as long as the number of receiving elements is large enough. We show that a linear analysis of training in a quantized system can be accurate when the thermal noise is high or the system is operating near its saturation rate.
Genetic survival analysis of age-at-onset of bipolar disorder: Evidence for anticipation and a year-of-birth effect in families (2000)

Age at onset (AAO) in a number of extended families ascertained for bipolar disorder was analyzed using survival analysis techniques, fitting proportional hazards models to estimate the fixed effects of sex, year-of-birth, generation, and a random polygenic genetic effect. Data comprised of the AAO (for 175 affecteds) or age when last seen (ALS) for 370 unaffecteds, on 544 individuals in 29 families. ALS was treated as a censored observation in the statistical analyses. The majority of individuals classified as affected were diagnosed with bipolar 1 and 2 (N=86) or recurrent major depressive disorder (N=61). In addition to the significant effects of sex and year-of-birth, a fitted 'generation' effect was highly significant, which could be interpreted as proof for an anticipation effect. The risk of developing bipolar or unipolar disorder increased two-fold with each number of generations further from the oldest founder. However, although information from both affected and unaffected individuals was used to estimate the relative risk of subsequent generations, it is possible that the results are biased because of the "Penrose effect". Females had a two-fold increased risk in developing depressive disorder relative to males. The risk of developing bipolar or unipolar disorder increased by approximately 5% per year of birth. A polygenic component of variance was estimated, resulting in a 'heritability' of AAO of approximately 0.40. In a family showing strong evidence of linkage to chromosome 4p (F22), the 'affected haplotype' increased the risk of being affected by a factor of 38. In this family, there was no evidence for anticipation and no increase in trinucleotide repeats measured by the RED method in affected individuals compared to controls. It is concluded that proportional hazard models are appropriate to analyze AAO data, and the methodology will be extended to map a QTL for AAO.
Erratum to: Digital PCR provides sensitive and absolute calibration for high throughput sequencing (2009)

nucleic acid (LNA) probe is 5'-TCGCCGCC-3'. This typographical error does not affect any of the conclusions drawn in the article.
Polymer nanocomposite based chemiresistive NO2 gas sensor (2008)

Emission of harmful gases into the atmosphere pollutes the environment. These pollutants may have deleterious effects on ecosystems and affect human health. In order to control the emission of these harmful gases we first need to detect them. We present here the development of a polymer nanocomposite based gas sensor for detecting trace gas emissions in ambient environment. This project aims to build a compact, readily deployable and cost-effective gas sensor that produces measurable electrical resistance changes due to interaction of NO2 with a nanocomposite. Our sensor demonstrates parts-per billion (ppb) sensitivity with improved specificity into the ppb range through innovative functionalization and packaging of nanomaterial.
Effect of a Targeted Education Intervention on the Incidence of Waste-Burning Injuries in a Military Population (2009)

The burning of waste is a common cause of accidental injury on the battlefield. This study was devised to determine the incidence of burns incurred while burning waste during U.S. military operations prior to and following an intervention targeted at reducing such injuries. The intervention consisted of memoranda outlining potential dangers and suggesting improved safety procedures. It was distributed to the combat theater (Iraq and Afghanistan) in March 2004. We reviewed military burn center records from March 2003 to March 2005. Demographics, injury data, and outcomes were recorded and compared between those casualties injured prior to and following the initiative. Twenty-four patients were injured while burning waste, 10% of military casualties admitted to the burn center during the study period. From March 2003 to March 2004, 20 patients were admitted with such injuries. The incidence of 1.67 per month was significantly (P<.05) higher than that seen the year after the intervention (four patients, 0.33 per month). TBSA burned was not different between the two time periods (9.8+/-8% before vs 6.3+/-7% after, P=.43). There were no deaths, and only one patient had an associated nonburn injury. Only 54% of patients returned to military duty. The initiative was followed by a significant decrease in the incidence of waste-burning injuries. We conclude that the initiative was successful and highlights the importance of continued military burn surveillance and prevention efforts.
Development of Ga Salt of Molybdophosphoric Acid for Biomass Conversion to Levulinic Acid (2016)

Efficient catalytic methods for biomass conversion present a challenge for the sustainable production of fuels and chemicals. Ga salt of molydophosphoric acid (GaHPMo) is prepared using a sonochemical irradiation method. Simultaneous formation of GaHPMo and entrapment of polyoxometallate in gallium micro-/nanoparticles (Ga@HPMo) is achieved. The amount of entrapped hetropoly acid in Ga particles is estimated to be ∼3 wt %, as determined from thermogravimetric analysis (TGA) and ultraviolet–visible (UV–vis) analysis. The preparation of GaHPMo is accomplished by subjecting an ethanolic solution of polyoxometallate [molybdophosphoric acid (HPMo)] and molten Ga metal to sonication at 50 °C for 12 min. Physicochemical properties of GaHPMo are studied using X-ray diffraction, TGA, temperature-programmed desorption, differential scanning calorimetry, Fourier transform infrared spectroscopy, UV–vis spectroscopy, scanning electron microscopy, transmission electron microscopy, dynamic light scattering, and energy-dispersive X-ray spectroscopy analysis. GaHPMo was successfully used as a catalyst for the conversion of various carbohydrates (glucose, starch, and cellulose) and rice straw into levulinic acid via a hydrothermal process. Reaction conditions for obtaining an optimum yield of levulinic acid from glucose are deduced (time, 10 h; temperature, 423 K; and mole ratio of the catalyst/reactant, 1:5). The reaction products are analyzed qualitatively using nuclear magnetic resonance (13C and 1H) spectroscopy and quantified using high-performance liquid chromatography analysis. The maximum yield of levulinic acid obtained from glucose is 56 wt %. Apart from the major product, levulinic acid, other minor byproducts, such as formic and lactic acids, are also observed.
3D bioprinting for high-throughput screening: Drug screening, disease modeling, and precision medicine applications (2019)

High-throughput technologies have become essential in many fields of pharmaceutical and biological development and production. Such technologies were initially developed with compatibility with liquid handling-based cell culture techniques to produce large-scale 2D cell culture experiments for the compound analysis of candidate drug compounds. Over the past two decades, tools for creating 3D cell cultures, organoids, and other 3D <i>in vitro</i> models, such as cell supportive biomaterials and 3D bioprinting, have rapidly advanced. Concurrently, a significant body of evidence has accumulated which speaks to the many benefits that 3D model systems have over traditional 2D cell cultures. Specifically, 3D cellular models better mimic aspects such as diffusion kinetics, cell-cell interactions, cell-matrix interactions, inclusion of stroma, and other features native to <i>in vivo</i> tissue and as such have become an integral part of academic research. However, most high throughput assays were not developed to specifically support 3D systems. Here, we describe the need for improved compatibility and relevant advances toward deployment and adoption of high throughput 3D models to improve disease modeling, drug efficacy testing, and precision medicine applications.