gebhart/patrepeval huggingface dataset:
Integration of Experimental Hydroprocessing and FCC Data with Process (Aspen Plus) and Refinery Optimization (Aspen PIMS) Models (2023)

NREL's Economic, Sustainability, and Market Analysis (ESMA) team develops process models in Aspen Plus to support techno-economic analysis (TEA) and life-cycle assessment (LCA) of conversion pathways from renewable and circular resources to fuels and chemicals. These tools are being applied to assess probable operational constraints or bottlenecks associated with refinery co-processing and repurposing opportunities. The team also utilizes optimizable refinery models to quantify opportunities for biofuel and bioproduct pathways through integration with existing refining infrastructure. The goals of analysis are to model the transition of refineries to renewable and circular feedstocks and quantify the costs production and CO2 abatement through utilization of existing refineries. At the core of the ESMA team's work is the process data derived from conversion experiments on hydroprocessing and fluid catalytic cracking performed at NREL. The objective of this presentation is to highlight new analysis approaches and capabilities in pathway analysis and refinery optimization modeling with specific emphasis on integration of experimental data.
A visibility improvement technique for fog images suitable for real-time application (2013)

Cameras used in outdoor scenes require high visibility performance under various environmental conditions. We present a visibility improvement technique which can improve the visibility of images captured in bad weather such as fog and haze, and also applicable to real-time processing in surveillance cameras and vehicle cameras. Our algorithm enhances contrast pixel by pixel according to the brightness and sharpness of neighboring pixels. In order to reduce computational costs, we preliminarily specify the adaptive functions which determine contrast gain from brightness and sharpness of neighboring pixels. We optimize these functions using the sets of fog images and examine how well they can predict the fog-degraded area using both qualitative and quantitative assessment. We demonstrate that our method can prevent excessive correction to the area without fog to suppress noise amplification in sky or shadow region, while applying powerful correction to the fog-degraded area. In comparison with other real-time oriented methods, our method can reproduce clear-day visibility while preserving gradation in shadows and highlights and also preserving naturalness of the original image. Our algorithm with low computational costs can be compactly implemented on hardware and thus applicable to wide-range of video equipments for the purpose of visibility improvement in surveillance cameras, vehicle cameras, and displays.
Low Levels of Circulating CS1, a Newly Identified Multiple Myeloma (MM) Antigen for a Novel Humanized HuLuc63 Monoclonal Antibody, Is Detected in MM Patient Sera and Correlates with Active Disease. (2007)

Abstract A new humanized anti-CS1 mAb HuLuc63 significantly induces antibody-dependent cellular cytotoxicity (ADCC) against autologous CS1-expressing patient MM cells. Here we examined whether soluble CS1 is detectable in MM patient sera and affects HuLuc63-induced cytotoxicity against MM cells. Using a sandwich ELISA, CS1 was detected in 44% (23/52) of sera of 52 MM patients (1.2 to 35.3 ng/ml). Immunoprecipitation of sera from CS1 ELISA-positive and -negative MM patients using anti-CS1 mAbs (HuLuc63 and ChLuc90) followed by immunoblotting with HuLuc63 and 1G9 recognizing different epitopes of CS1, further confirmed two forms of CS1 only in CS1-positive MM patient sera. Detection of CS1 is associated with MM (p &amp;lt; 0.0001), since it is detected in MM patient sera, but not in MGUS (n=15) or in healthy donors (n=100). In additional sera of 199 MM patients with newly diagnosed MM, 90% (181/199) of MM patients have detectable CS1 (1 to &amp;gt;80 ng/ml). Median CS1 levels for International Stage System (ISS) I (n=100), II (n=53), and III (n=46) patients are 5.87, 9.37, and 8.37 ng/ml, respectively. The correlation between ISS and CS1 is moderate (spearman correlation coefficient = 0.197, p=0.005). Patients with ISS II/III had significantly higher CS1 levels compared with those with ISS I (median 9.0 vs. 5.9 ng/ml, p=0.006), suggesting a correlation of serum CS1 with active MM. Since patients with ISS II and III require therapy, while those with ISS I do not, these results suggest that circulating CS1 may indicate need for therapy and further support clinical investigation of anti-CS1 therapy using HuLuc63 in MM. Importantly, HuLuc63 has demonstrated significant dose-dependant activity, leading to reduced or eliminated human myeloma tumors (MM1S, OPM2, and L363) in xenograft mice models. Anti-MM activity of HuLuc63 in mice could be observed at sustained serum levels of &amp;gt;2 mg/ml, which is well above the levels of circulating CS1 protein observed in MM patients. Thus, it is proposed that serum CS1 will be an unlikely antibody sink in patients treated with optimal doses of HuLuc63. Since NK cells also express CS1, albeit at lower levels than MM cells, we next determined the effects of HuLuc63 on NK cell function. Pretreatment of NK cells with HuLuc63 (0.1 mg/ml) for 3 days did not alter NK-mediated ADCC against CS1-expressing MM cells (MM1S, H929, INA-6) via HuLuc63. Moreover, recombinant CS1-Fc at physiological serum levels (&amp;lt;200 ng/ml) did not significantly inhibit HuLuc63-induced ADCC against MM cells. Inhibition of HuLuc63-induced MM cell lysis by CS1-Fc was observed at higher concentrations (&amp;gt;200 ng/ml), confirming specific HuLuc63-CS1 binding. Together, these studies strongly support continued clinical investigation of HuLuc63 in MM.
Weight-Change Trajectories of Pediatric Outpatients Treated with Risperidone or Aripiprazole in a Naturalistic Setting (2018)

Children were at risk of weight gain more than adolescents, for both risperidone and, of note, aripiprazole. Adolescents and patients with long previous drug exposure tend to reach stable BMI-Z, although in the range between excessive weight and obesity.
Nocardia exalbida sp. nov., isolated from Japanese patients with nocardiosis (2006)

Two bacterial strains isolated from different hospitals in Japan were subjected to a polyphasic analysis. Strains IFM 0803(T) and IFM 10383 were found to have morphological, biochemical, physiological and chemotaxonomic properties consistent with their classification in the genus Nocardia. Strains IFM 0803(T) and IFM 10383 clustered with the type strain of Nocardia xishanensis, showing 16S rRNA gene sequence similarities of 98.6-98.9 % with this species. The novel strains could be distinguished from N. xishanensis by a range of phenotypic properties. Based on their phenotypic and phylogenetic characteristics, the two isolates are proposed as members of a novel species of the genus Nocardia, Nocardia exalbida sp. nov., with the type strain IFM 0803(T) (=NBRC 100660(T) = JCM 12667(T) = DSM 44883(T)).
Automated Field Development Planning for Unconventional Shale Gas (2014)

Summary We present a framework that automatically generates an optimal well placement plan (WPP) based on a reservoir model of a shale gas field. The proposed WPP comprises wells, surface locations such as pads, well completion locations, and the drilling schedule. A suite of high-speed computational components allows generating this WPP in minutes. Different development strategies can be rapidly investigated. The WPP is optimized using a constrained downhill-simplex approach. During a trial, WPPs proposed by the optimizer in previous trials were extrapolated to propose a new WPP. The proposed WPP must satisfy a wide range of geometric, operational, contractual, and legal constraints on the surface as well as in the overburden and reservoir. When a feasible WPP is discovered during a trial, the production forecast is computed using a high-speed semianalytic reservoir simulator. The framework supports a variety of objective functions, including recovery, net present value, return on investment, and profitability index. Optimization in the presence of subsurface uncertainty considers an ensemble of reservoir models. A proposed WPP will then have an uncertainty in the forecast value. For a specified aversion to risk, a conservative or aggressive WPP can then be optimized.
Isolation, Cloning, and Expression of an Acid Phosphatase Containing Phosphotyrosyl Phosphatase Activity from Prevotella intermedia (1999)

A novel acid phosphatase containing phosphotyrosyl phosphatase (PTPase) activity, designated PiACP, from Prevotella intermedia ATCC 25611, an anaerobe implicated in progressive periodontal disease, has been purified and characterized. PiACP, a monomer with an apparent molecular mass of 30 kDa, did not require divalent metal cations for activity and was sensitive to orthovanadate but highly resistant to okadaic acid. The enzyme exhibited substantial activity against tyrosine phosphate-containing peptides derived from the epidermal growth factor receptor. On the basis of N-terminal and internal amino acid sequences of purified PiACP, the gene coding for PiACP was isolated and sequenced. The PiACP gene consisted of 792 bp and coded for a basic protein with an M(r) of 29,164. The deduced amino acid sequence exhibited striking similarity (25 to 64%) to those of members of class A bacterial acid phosphatases, including PhoC of Morganella morganii, and involved a conserved phosphatase sequence motif that is shared among several lipid phosphatases and the mammalian glucose-6-phosphatases. The highly conservative motif HCXAGXXR in the active domain of PTPase was not found in PiACP. Mutagenesis of recombinant PiACP showed that His-170 and His-209 were essential for activity. Thus, the class A bacterial acid phosphatases including PiACP may function as atypical PTPases, the biological functions of which remain to be determined.
Advances in Photodynamic Theory (1996)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Michael R. Hamblin and Tayyaba Hasan, "Advances in Photodynamic Theory," Optics & Photonics News 7(7), 16-21 (1996) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Assesment of DNA integrity of Palaemonidae spermatozoa using the alkaline Comet assay: a pertinent tools for environmental biomonitoring (2017)

International audience
ATPase Activity of Purified Multidrug Resistance-associated Protein (1997)

Human multidrug resistance protein (MRP) was expressed at high levels in stably transfected baby hamster kidney (BHK-21) cells. These cells exhibited a pattern of cross-resistance to several different drugs typical of an MRP-mediated phenotype despite the addition of 10 histidine residues at the C terminus to facilitate purification. Consistent with this functional evidence of the presence of MRP at the surface of these transfectants, strong signals were detected by immunoblotting and immunofluorescence using a specific monoclonal antibody to MRP. There was intense uniform staining of the cell surface as well as weaker staining of intracellular membranes. MRP-containing membranes were solubilized in 1% N-dodecyl-beta-D-maltoside in the presence of 0.4% sheep brain phospholipids. Two sequential affinity purification steps on Ni-NTA agarose and wheat germ agglutinin agarose provided substantial enrichment, and contaminating bands were not detected. ATPase activity of the purified protein was assayed in the presence of the phospholipids, which had been maintained throughout all purification steps. ATP was hydrolyzed in proportion to the amount of purified protein assayed, and typical Michaelis-Menten behavior was exhibited, yielding estimations of Km of approximately 3.0 mM and Vmax of 0.46 micromol mg-1 min-1. This activity was moderately stimulated by the drugs that others have shown to be transported by MRP-containing membrane vesicles. This stimulation was enhanced by reduced glutathione as is its drug transport, and oxidized glutathione, itself a substrate for transport, caused a strong stimulation. These data describe the first purification of MRP and provide the first direct evidence that the molecule possesses drug-stimulated ATPase activity.
Evaluating the quality of EDOF in camera phones (2010)

Extended Depth of Focus technologies are well known in the literature, and in recent years this technology has made its
way into camera phones. While the fundamental approach might have significant advantages over conventional
technologies, often in practice, it turns out the results can be accompanied by undesired artifacts that are hard to
quantify. In order to conduct an objective comparison with the conventional focus technology, new methods need to be
devised that are able to quantify not only the quality of focus but also the artifacts introduced by the use of EDOF
methods. In this paper we propose a test image and a methodology to quantify focus quality and its dependence on the
distance. Our test image is created from a test image element that contains different shapes to measure frequency
response.
Data from Intravaginal Administration of Fc-Fused IL7 Suppresses the Cervicovaginal Tumor by Recruiting HPV DNA Vaccine-Induced CD8 T Cells (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; The induction of tissue-localized virus-specific CD8 T-cell response is essential for the development of an effective therapeutic vaccine against genital diseases, such as cervical cancer and genital herpes. Here, we aimed to elucidate the immunologic role of IL7 in the induction of mucosal cellular immunity.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; IL7 was engineered through Fc fusion to enhance mucosal delivery across the genital epithelial barrier. The immunomodulatory role of IL7 was evaluated by monitoring the kinetics of various immune cells and measuring the expression of chemokines and cytokines after intravaginal administration of Fc-fused IL7 (IL7-Fc). The antitumor effects of intramuscular human papillomavirus (HPV) DNA vaccine or topical IL7-Fc alone or in a combinational regimen on mice survival were compared using a orthotopic cervical cancer model.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Intravaginal treatment of IL7-Fc, but not native IL7, induces upregulation of chemokines (CXCL10, CCL3, CCL4, and CCL5), cytokines (IFNγ, TNFα, IL6, and IL1β), and an adhesion molecule (VCAM-1) in the genital tract, leading to the recruitment of several leukocytes, including CD4, CD8, γδ T cells, and dendritic cells. Importantly, in this murine cervical cancer model, topical administration of IL7-Fc after intramuscular HPV DNA vaccination increases the number of HPV-specific CD8 T cells in the genital mucosa, but not in the spleen, leading to stronger antitumor activity than the HPV DNA vaccine alone.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Our findings provide an important insight into the immunomodulatory role of IL7-Fc via topical application and the design of therapeutic vaccine regimen that induces effective genital–mucosal CD8 T-cell responses. &lt;i&gt;Clin Cancer Res; 22(23); 5898–908. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Chronic restraint via tail immobilization of mice: effects on corticosterone levels and other physiologic indices of stress. (2002)

Chronic venous cannulation in mice is an acceptable and useful technique for repeated blood sampling or continuous intravenous administration of substances, for which mild restraint of the animal may be necessary. Because chronic restraint has drawn considerable attention in the animal welfare community, the purpose of this study was to evaluate physiologic indices of stress in mice restrained by using an established tail restraint method. Serum corticosterone levels and body, thymus, adrenal, and spleen weights on days 2, 5, 8, and 12 were compared between tail-restrained and unrestrained mice. There were no significant differences between the two groups at the time points evaluated. Corticosterone levels were highest on day 8 for both groups and were significantly different from those on days 2 (P<0.009) and 5 (P<0.04) for restrained mice and on day 2 (P<0.02) for unrestrained mice. Levels in both groups declined by day 12, suggesting habitation. Weight loss was observed in all mice whether restrained or unrestrained. Significant differences in body, thymus, adrenal, and spleen weights were not evident between restrained and unrestrained mice. This study provides important information for balancing issues of prolonged restraint, animal well-being, and research goals.
Organic Perfluorohalogenate Salts; New Energetic Materials (2014)

Abstract : The objective of this research project is to develop a new class of energetic materials comprised of an organic fuel (i.e NH4+) paired with a strong oxidizing perfluorohalogenate anion (i.e. BrF4-). New EM compounds will be synthesized, fully characterized and evaluated for counter-CBW applications.
Robotic dipping system for layer-by-layer assembly of multifunctional thin films (2005)

A simple, yet very flexible robotic dipping system for the preparation of functional thin films is presented. These films are deposited onto a substrate using the layer-by-layer assembly technique. The robot alternately dips a substrate into aqueous mixtures containing oppositely charged or otherwise complementary species. Samples can be spray rinsed (a unique feature of this robot relative to others created for thin film deposition) and blow dried after each dip. Dipping, rinsing, and drying times are adjustable and up to twelve mixtures can be deposited in any order. An example 20-bilayer film was prepared using aqueous mixtures of carbon black stabilized with polyethylenimine and poly(acrylic acid). This film exhibits low resistivity (&amp;lt;0.2Ω∙cm) and is free of the porosity and brittleness that are characteristic of highly filled polymer composites. The robotic dipping system is especially useful for films requiring more than tenbilayers and a variety of different layers.
Efficient Tin-Free Route to a Donor–Acceptor Semiconducting Copolymer with Variable Molecular Weights (2014)

For the fabrication of efficient photovoltaic devices and thin-film transistors, π-conjugated polymers with high molecular weight are desirable as they frequently show superior charge transport, morphological, and film-forming properties. Herein, we present an extremely fast tin-free method to polymerize a naphthalene diimide-dithiophene-based anion-radical monomer in the presence of Pd catalyst having bulky and electron-rich tritert-butylphosphine ligands (Pd/PtBu3). With this method, the corresponding semiconducting polymer, PNDIT2 (also known as P(NDI2OD-T2 or N2200) with a molecular weight in excess of 1000 kg/mol can be obtained quickly at room temperature and at rather low catalyst concentrations. In general, molecular weights of resulting polymer can be regulated by reaction conditions (e.g., catalyst concentration and reaction time). Besides high molecular weight PNDIT2 (e.g., with MN ∼ 350 kg/mol, ĐM =2.9), PNDIT2 with moderate molecular weight (e.g., MN ∼ 110 kg/mol, ĐM = 2.3) and low molecular weight (e.g., MW ∼ 12 kg/mol, ĐM = 1.9), can also be obtained. It was found that thus-prepared PNDIT2 exhibits field-effect electron mobilities of up to ∼0.31 cm2/(V s), similar to the Stille-derived N2200 control polymer (up to ∼0.33 cm2/(V s)). Preliminary studies demonstrated that Pd/PtBu3 catalyst is remarkably efficient in polymerizing of other anion-radical monomers, such as isoindigo-, and diketopyrrolopyrrole-based ones, although conventional Ni and Pd catalysts (e.g., Ni(dppp)Cl2, Ni(dppp)Cl2, Pd(PPh3)4) failed to polymerize these monomers.
The Sustained-Exposure Dexamethasone Formulation OTO-104 Offers Effective Protection against Noise-Induced Hearing Loss (2015)

The otoprotective effects of OTO-104 were investigated both prior to and following acute acoustic trauma. Guinea pigs received a single intratympanic injection of OTO-104 and were assessed in a model of acute acoustic trauma. Doses of at least 2.0% OTO-104 offered significant protection against hearing loss induced by noise exposure when administered 1 day prior to trauma and up to 3 days thereafter. Otoprotection remained effective even with higher degrees of trauma. In contrast, the administration of a dexamethasone sodium phosphate solution did not protect against noise-induced hearing loss. Activation of the classical nuclear glucocorticoid and mineralocorticoid receptor pathways was required for otoprotection by OTO-104. The sustained exposure properties of OTO-104 were also superior to a steroid solution.
Supplementary Figure 2 from Twist Overexpression Induces <i>In vivo</i> Angiogenesis and Correlates with Chromosomal Instability in Breast Cancer (2023)

Supplementary Figure 2 from Twist Overexpression Induces &lt;i&gt;In vivo&lt;/i&gt; Angiogenesis and Correlates with Chromosomal Instability in Breast Cancer
Solutions for GSM narrowband deployment (2003)

The outstanding performance of GSM and its promising evolution towards 3G services have oriented new operators to bet for this technology to deploy their mobile communication networks. However, the spectrum is a scarce resource and some new networks have to be initially deployed with a bandwidth lower than 5 MHz. Moreover, the inherent characteristics of GSM make the deployment a bit difficult due to the loose reuses normally required for BCCH frequencies. This paper presents results and conclusions of a study that aims at providing basic guidelines to deploy narrowband networks and achieve the maximum spectral efficiency with a very limited bandwidth. A network simulator and some trial results have been used during the study.
Terahertz Measurements and their Applications (2021)

This short course discusses several of the most commonly used techniques for performing measurements in the terahertz (THz) region of the electromagnetic spectrum. This spectral range has received heightened attention in recent years, due to the many promising applications ranging from fundamental spectroscopic measurements of materials to imaging and sensing for security, quality control, wireless communications, and process monitoring. Many different systems have been developed for accessing the THz range based on a wide range of different technology platforms, each with its own capabilities and challenges.
A low-cost protocol and application for UWB localization, exploiting cross-layer design and cognitive radio aspects (2009)

The EUWB (Coexisting Short Range Radio by Advanced Ultra-Wideband Radio Technology, FP7-ICT-215669, www.euwb.eu) project has been an industry-led initiative of twenty-one major industrial and excellent academic organizations from Europe and Israel targeting innovative improvement, adaptation, integration and application of short- range Ultra-Wideband Radio Technology (UWB-RT). Started in April 2008, the EUWB project has leveraged and enhanced the scientific knowledge base in the advanced UWB-RT and has provided sophisticated new applications enabled by UWB and highly demanded in several European key industrial sectors such as home entertainment consumer electronics, automotive, public transportation, and heterogeneous cellular networks. Within EUWB, major fields of this emerging challenge have been identified, such as the cognitive radio related Detect-And-Avoid (DAA) technology and the localization and tracking (LT) technology. An important aspect is to design an LT protocol. In this manuscript the authors will first illustrate the technical approach of EUWB, giving a brief overview of the project.