gebhart/patrepeval huggingface dataset:
SYN-007, an Orally Administered Beta-Lactamase Enzyme, Protects the Gut Microbiome from Oral Amoxicillin/Clavulanate without Adversely Affecting Antibiotic Systemic Absorption in Dogs (2020)

Beta-lactamases, enzymes produced by bacteria to degrade beta-lactam antibiotics, have been harnessed as therapeutics to protect the gut microbiome from damage caused by antibiotics. Proof-of-concept of this approach using SYN-004 (ribaxamase), a beta-lactamase formulated for oral delivery with intravenous (IV) penicillins and cephalosporins, was demonstrated with animal models and in humans. Ribaxamase degraded ceftriaxone in the gastrointestinal tract, protected the gut microbiome, significantly reduced the incidence of <i>Clostridioides</i> <i>difficile</i> disease and attenuated emergence of antibiotic resistant organisms. SYN-007 is a delayed release formulation of ribaxamase intended for use with oral beta-lactams. In dogs treated with oral amoxicillin, SYN-007 diminished antibiotic-mediated microbiome disruption and reduced the emergence of antibiotic resistance without altering amoxicillin systemic absorption. Here, SYN-007 function in the presence of clavulanate, a beta-lactamase inhibitor, was investigated. Dogs received amoxicillin (40 mg/kg, orally (PO), three times a day (TID)) or the combined antibiotic/beta-lactamase inhibitor, amoxicillin/clavulanate (40 mg/kg amoxicillin, 5.7 mg/kg clavulanate, PO, TID) +/- SYN-007 (10 mg, PO, TID) for five days. Serum amoxicillin levels were not significantly different +/- SYN-007 compared to amoxicillin alone or amoxicillin/clavulanate alone as controls for both first and last doses, indicating SYN-007 did not interfere with systemic absorption of the antibiotic. Whole genome shotgun metagenomics analyses of the fecal microbiomes demonstrated both amoxicillin and amoxicillin/clavulanate significantly reduced diversity and increased the frequency of antibiotic resistance genes. Microbiome damage appeared more severe with amoxicillin/clavulanate. In contrast, with SYN-007, microbiome diversity was not significantly altered, and frequency of antibiotic resistance genes did not increase. Importantly, SYN-007 functioned in the presence of clavulanate to protect the gut microbiome indicating that SYN-007 activity was not inhibited by clavulanate in the dog gastrointestinal tract. SYN-007 has the potential to expand microbiome protection to beta-lactam/beta-lactamase inhibitor combinations delivered orally or systemically.
Validierung einer Qualifizierungsmethodik für neue Werkstoffe beim laserbasierten Strahlschmelzen (2011)

Im Bereich generativer Fertigung wird seit einigen Jahren versucht, das Spektrum der einsetzbaren Werkstoffe kontinuierlich zu erweitern. Voraussetzung hierfur ist es, geeignete Prozessparameter fur neue Werkstoffe zu identifizieren. Am Institut fur Produktions-management, Technologie und Werkzeugmaschinen der Technischen Universitat Darmstadt ist eine Methode entwickelt worden, um neue Pulverwerkstoffe fur das laserbasierte Strahlschmelzen zu qualifizieren. Hauptbestandteil dieser Qualifizierungsmethodik ist die Variation einzelner Prozessparameter und die Analyse der dadurch erreichten Bauteilqualitat. Zur Validierung ist die Qualifizierungsmethodik auf zwei bekannte Werkstoffe angewendet worden. Die hierdurch erhaltenen Bauteileigenschaften sind mit den Herstellerangaben verglichen worden. Es kann festgehalten werden, dass durch Anwendung der Qualifizierungsmethodik valide Prozessparameter fur neue Pulverwerkstoffe identifiziert werden konnen.

In the field of additive manufacturing, many attempts have been made to continuously expand the range of available materials within the last years. For this purpose it is required to identify applicable process parameters for new materials. At the Institute for Production Management, Technology and Machine Tools at Technische Universitat Darmstadt a method to qualify new powder materials for laser melting is developed. The main focus of this qualification method is the variation of single process parameters and an analysis of the hereby achieved surface quality. For validation purposes, the qualification method is applied to two commercially available materials. The parts’ properties using the obtained process parameters are compared to the parts’ properties using the materials’ default parameters. It can be shown that the developed qualification method provides valid process parameter sets for new powder materials.
Source Aware Modulation for leveraging limited data from heterogeneous sources (2021)

In many personalized prediction applications, sharing information between entities/tasks/sources is critical to address data scarcity. Furthermore, inherent characteristics of sources distinguish relationships between input drivers and response variables across entities. For example, for the same amount of rainfall (input driver), two different basins will have very different streamflow (response variable) values depending on the basin characteristics (e.g., soil porosity, slope, …). Given such heterogeneity, a trivial merging of data without source characteristics would lead to poor personalized predictions. In recent years, meta-learning has become a very popular framework to learn generalized global models that can be easily adapted (fine-tuned) for individual sources. In this talk, we present an exhaustive analysis of the source-aware modulation based meta-learning approach. Source-aware modulation adjusts the shared hidden features based on source characteristics. The adjusted hidden features are then used to calculate the response variable for individual sources. Although this strategy shows promising prediction improvement, its applicability is limited in certain applications where source characteristics might not be available (especially due to privacy concerns). In this work, we show that robust personalized predictions can be achieved even in the absence of explicit source characteristics. We investigated the performance of different modulation strategies under various data sparsity settings on two datasets. We demonstrate that source-aware modulation is a very viable solution (with or without known characteristics) compared to traditional meta-learning methods such as model agnostic meta-learning.
Enantioselective Total Synthesis of 13,14,15-Isocrambescidin 800 (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTEnantioselective Total Synthesis of 13,14,15-Isocrambescidin 800D. Scott Coffey, Andrew I. McDonald, Larry E. Overman, and Frank StappenbeckView Author Information Department of Chemistry, 516 Rowland Hall University of California, Irvine, California 92697-2025 Cite this: J. Am. Chem. Soc. 1999, 121, 29, 6944–6945Publication Date (Web):July 7, 1999Publication History Received29 March 1999Published online7 July 1999Published inissue 1 July 1999https://pubs.acs.org/doi/10.1021/ja990992chttps://doi.org/10.1021/ja990992crapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views940Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Chemical synthesis,Condensation,Guanidine,Organic compounds,Organic synthesis Get e-Alerts
On the Capacity Statistics of MIMO Ricean and Rayleigh Fading Channels (2006)

In this work, we provide a new framework for the analysis of the multiple-input multiple-output (MIMO) Ricean and Rayleigh fading channel capacity statistics under the assumption of perfect channel knowledge at the receiver, no channel state information at the transmitter and isotropic Gaussian distributed inputs. More specifically, we show that by deriving the marginal densities of the unordered eigenvalues of (non) central Wishart matrices, it is possible to generalize Telatar's approach for evaluating the average channel capacity, to derive the capacity variance as well as its higher order statistics, such as its skewness and kurtosis, for a class of MIMO fading environments, including the uncorrelated Rician and Rayleigh fading and the semicorrelated Rayleigh fading, thereby alleviating the need to resort to the moment generating function approach so far used in the open literature. Numerical results are also provided and sustained by Monte Carlo simulations in order to show the perfect match between the theoretical and simulation results.
epic2 efficiently finds diffuse domains in ChIP-seq data (2019)

Supplementary data are available at Bioinformatics online.
Multiview Rectification of Folded Documents (2017)

Digitally unwrapping images of paper sheets is crucial for accurate document scanning and text recognition. This paper presents a method for automatically rectifying curved or folded paper sheets from a few images captured from multiple viewpoints. Prior methods either need expensive 3D scanners or model deformable surfaces using over-simplified parametric representations. In contrast, our method uses regular images and is based on general developable surface models that can represent a wide variety of paper deformations. Our main contribution is a new robust rectification method based on ridge-aware 3D reconstruction of a paper sheet and unwrapping the reconstructed surface using properties of developable surfaces via conformal mapping. We present results on several examples including book pages, folded letters and shopping receipts.
Discovery and Supramolecular Interactions of Neutral Palladium‐Oxo Clusters Pd16and Pd24 (2020)

We report on the synthesis, structure, and physicochemical characterization of the first three examples of neutral palladium-oxo clusters (POCs). The 16-palladium(II)-oxo cluster [Pd<sub>16</sub> O<sub>24</sub> (OH)<sub>8</sub> ((CH<sub>3</sub> )<sub>2</sub> As)<sub>8</sub> ] (Pd<sub>16</sub> ) comprises a cyclic palladium-oxo unit capped by eight dimethylarsinate groups. The chloro-derivative [Pd<sub>16</sub> Na<sub>2</sub> O<sub>26</sub> (OH)<sub>3</sub> Cl<sub>3</sub> ((CH<sub>3</sub> )<sub>2</sub> As)<sub>8</sub> ] (Pd<sub>16</sub> Cl) was also prepared, which forms a highly stable 3D supramolecular lattice via strong intermolecular interactions. The 24-palladium(II)-oxo cluster [Pd<sub>24</sub> O<sub>44</sub> (OH)<sub>8</sub> ((CH<sub>3</sub> )<sub>2</sub> As)<sub>16</sub> ] (Pd<sub>24</sub> ) can be considered as a bicapped derivative of Pd<sub>16</sub> with a tetra-palladium-oxo unit grafted on either side. The three compounds were fully characterized 1) in the solid state by single-crystal and powder XRD, IR, TGA, and solid-state <sup>1</sup> H and <sup>13</sup> C NMR spectroscopy, 2) in solution by <sup>1</sup> H, <sup>13</sup> C NMR and <sup>1</sup> H DOSY spectroscopic methods, and 3) in the gas phase by electrospray ionization mass spectrometry (ESI-MS).
Pattern formation and developmental mechanisms Converging views of diverging pathways (1998)

One of the great themes in modern developmental biology is the underlying unity of developmental mechanisms that govern pattern formation in all animals. Superficially, many classical paradigms of developmental patterning appear to be quite different. In the last decade, these classical experimental systems have been found to be based upon similar signaling pathways and regulatory hierarchies. For example, anterior/posterior patterning in all animals are governed by the genes in the Hox cluster(s), and axis formation in the frog egg, limb development and pattern formation in insect wings are established by common signaling pathways. There has been great joy in discovering the unity in mechanisms for developmental patterning and there is also great power in knowing that similar types of genetic pathways regulate patterning in all animals.
Measurements of interfacial strengths in underfilled flip-chip electronic packages using Wedge Delamination Method (WDM) (2014)

In this work, a new wedge delamination technique for measurement of interfacial fracture strength is presented. This method can be implemented to assess the interfacial fracture behavior of underfill and silicon in flip-chip packages. Our method offers substantial advantages over traditional interfacial test methods which can be difficult to implement on brittle materials like silicon die. The efficacy of our method for interfacial strength measurements on multiple underfill-silicon interfaces will be shown in this work. A numerical framework for crack kinking at the silicon-underfill interface will also be presented. And finally, results from WDM experiments conducted at room temperature and corresponding numerical analysis will be used to compare the relative fracture strength between underfill and silicon at the flat-face and sidewall of a silicon die.
<title>Investigation of photorefractive nonlinear optical properties of iron-doped lithium niobate in bulk and fiber configurations</title> (2002)

In this work we present the experimental results of contradirectional two-beam coupling in a bulk crystal and single crystal fibers of iron-doped lithium niobate. Results of a reduction of the grating writing instability, a comparison of the two-beam coupling efficiency of the fibers and bulk crystal as a function of focusing geometry, as well as a comparison of theoretical and experimental results of the two-beam coupling efficiency are presented.
Abstract 11565: Improvement in Cardiopulmonary Function in a Rat Model of Pulmonary Arterial Hypertension Observed With RKER-012, a Novel Activin Receptor Type II Ligand Trap, was Associated With Reduced Markers of Inflammation and Fibrosis in the Right Ventricle (2022)

Pulmonary arterial hypertension (PAH) is characterized by elevated pulmonary vascular resistance, impaired cardiac output, and right ventricle (RV) overload. PAH is associated with imbalanced TGF-ß signaling, marked by elevated SMAD2/3 signaling, which is associated with inflammation and fibrosis contributing to heart failure. Initially, the RV can compensate for increased pressure due to its adaptive contractility, but chronic pressure overload leads to maladaptive RV remodeling through inflammatory and fibrotic pathways. Current therapies for PAH are primarily vasodilators which do not treat the underlying pathology. RKER-012 is a research form of KER-012, an investigational modified ActRIIB ligand trap designed to inhibit signaling through SMAD2/3. We investigated RKER-012’s mechanism of prevention of cardiac pathology in a Sugen/Hypoxia (SH) PAH model. Rats received a subcutaneous (SQ) dose of 25 mg/kg Sugen 5416 under hypoxic conditions. For 3 weeks, SH rats received vehicle (SH-VEH) or 10 mg/kg RKER-012 (SH-RKER-012) twice weekly SQ. Control rats received VEH twice weekly in normoxic conditions. Systolic pulmonary arterial pressure (sPAP) and Fulton index (FI) were measured. qPCR of RV tissue was used to evaluate the mechanism of RKER-012 in this model. SH-VEH rats had increased FI and sPAP (both p≤0.0001) compared to NX, consistent with development of cardiac and pulmonary impairment. Relative to SH-VEH, RKER-012 reduced increased FIand prevented increased sPAP (both p≤0.001) in SH rats so that sPAP did not differ from NX. Relative to NX, SH-VEH had increased RV expression of fibrotic markers such as Timp1, Col1a1, Col3a1, Runx2, and LOX (all p≤0.05). In contrast, SH-RKER-012 rats had reduced expression of Timp1, Col1a1, Col3a1, Runx2 and LOX (all p≤0.05) relative to SH-VEH. Inflammation markers CD68 and MCP1 (both p≤0.05) were increased in SH-VEH compared to NX. CD68 expression was reduced in SH-RKER-012 (p≤0.01) compared to NX but MCP1 expression was not affected (p=0.54). These results support that RKER-012 attenuated upregulation of key inflammation and fibrosis markers in a PAH preclinical model and suggest that KER-012 has a distinct mechanism from vasodilation and could be developed as a cardioprotective treatment for PAH.
Noise properties of ferromagnetic tunnel junctions (1998)

We report measurements of voltage fluctuations in magnetic tunnel junctions which exhibit both high and low magnetoresistance (MR). The voltage noise power normalized to the square of the junction bias voltage was 10−14/Hz at a frequency of 1 Hz in a high MR junction. Low MR junctions had significantly higher noise power at 1 Hz and the origin of the noise was not magnetic. In these junctions, random telegraph noise was observed over a wide range of temperatures and junction biases. The results are consistent with a two-channel model of conduction, one of which is spin independent and gives rise to large noise. A noise measuring technique provides evidence for bias-dependent current-path rearrangements. The data support the existence of an inhomogeneous (filamentary-like) current-flow pattern across the tunnel junction associated with the spin-independent channel.
VIV Disproportionation Upon Sodium Extraction From Na3V2(PO4)2F3 Observed by Operando X-ray Absorption Spectroscopy and Solid-State NMR (2017)

Among the series of polyanionic positive electrodes for sodium-ion batteries having the general formula Na3V2(PO4)2F3–yOy (0 ≤ y ≤ 2), the composition Na3V2(PO4)2F3 (y = 0) has the highest theoretical energy that offers competitive electrochemical performances compared to sodium transition metal oxides. Recently, the structural phase diagram from Na3V2(PO4)2F3 to Na1V2(PO4)2F3 has been thoroughly investigated by operando synchrotron X-ray diffraction revealing an unexpected structural feature for the end member composition. In fact, the crystal structure of Na1V2(PO4)2F3 has two very different vanadium environments within each bioctahedron that suggests a charge disproportionation of two VIV into VIII and VV. This work shows an operando X-ray absorption spectroscopy at vanadium K edge during the electrochemical extraction of Na+ in order to monitor the redox processes involved in this compound. The large data set provided by this experiment has been processed by the principal component analysis combined with multivariate curve resolution. The results suggest that the bioctahedra have to be considered as the basic structural unit. The peculiar geometry of this material combined with the mixed vanadium valence, directly investigated here along the reaction, seems to allow original electronic configurations. In particular, the two vanadium sites into the basic bioctahedra unit evolve from VIII–VIII to VIII–VIV and to a final VIII–VIV configuration. These observations are completed with 51V NMR sensitive to diamagnetic VV.
On The Outage Performance Of Line-Of-Sight Massive MIMO with a Fixed-Length Uniform Linear Sparse Array (2019)

Increasing the inter-element spacing of a uniform linear sparse array results in reducing the mutual coupling and simplifying the heat dissipation control of the array. However, increasing the inter-element spacing may result in the appearance of grating lobes in the field-of-view (FoV). In this paper, 0.05-outage capacity is used as the performance metric to optimize the inter-element spacing for a given array size in line-of-sight scenarios. For the case of two users, we propose to increase the inter-element spacing as long as the 0.05-outage capacity does not reduce more than 1% compared to the capacity achieved when the two users have orthogonal channel vectors. Radiated power at the base station is adjusted to have the same effective isotropic radiated power for different arrays. Simulation results for an array size of 40λ show that for FoVs of 60° to 120°, the inter-element spacing can be increased from 0.5λ to more than 1.14λ.
Ultrasound Detection of Myocardial Ischemic Memory Using an E-Selectin Targeting Peptide Amenable to Human Application (2014)

Vascular endothelial leukocyte adhesion molecules, such as E-selectin, are acutely upregulated in myocardial ischemia/reperfusion and are thus “ischemic memory” biomarkers for recent cardiac ischemia. We sought to develop an ultrasound molecular imaging agent composed of microbubbles (MBs) targeted to E-selectin to enable the differential diagnosis of myocardial ischemia in patients presenting with chest pain of unclear etiology. Biodegradable polymer MBs were prepared bearing a peptide with specific human E-selectin affinity (MB ESEL ). Control MBs had scrambled peptide (MB CTL ) or nonspecific IgG (MB IgG ). MB ESEL adhesion to activated rat endothelial cells (ECs) was confirmed in vitro in a flow system and in vivo with intravital microscopy of rat cremaster microcirculation. Ultrasound molecular imaging of recent myocardial ischemia was performed in rats 4 hours after transient (15 minutes) coronary occlusion. MB ESEL adhesion was higher to inflamed versus normal ECs in vitro; there was no difference in MB CTL or MB IgG adhesion to inflamed versus normal ECs. There was greater adhesion of MB ESEL to inflamed versus noninflamed microcirculation and minimal adhesion of MB CTL or MB IgG under any condition. Ultrasound imaging after injection of MB SEL demonstrated persistent contrast enhancement of the previously ischemic region. Videointensity in postischemic myocardium after MB ESEL was higher than that in the nonischemic bed (11.6 ± 2.7 dB vs 3.6 ± 0.8 dB, p &lt; .02) and higher than that after MB CTL (4.0 ± 1.0 dB, p &lt; .03) or MB IgG (1.7 ± 0.1 dB, p &lt; .03). MBs targeted to E-selectin via a short synthetic peptide with human E-selectin binding affinity enables echocardiographic detection of recent ischemia, setting the stage for clinical myocardial ischemic memory imaging to identify acute coronary syndromes.
Real-time detection and classification of traffic light signals (2016)

Traffic light detection is an important part of Advanced Driver Assist as well as autonomous vehicle systems which ensures timely and appropriate reaction to traffic lights (TLs) in cross sections. In this paper we introduce a robust and realtime approach to detect TLs and recognize its status in complex traffic scenes solely based on image processing techniques. The proposed system uses color properties of the scene to detect TLs in real-time. An innovative technique has been developed to significantly decrease compute requirement for detection of TL color by using one Lookup Table independent of lighting conditions. Each candidate region is further analyzed, using features analysis, to segregate actual TL signals among all candidate regions. As in similar machine learning techniques, an unsupervised classifier using a set of significant features has been developed to accurately segregate circular, semi-circular, and arrow shaped TL signals without using a training dataset. The final C++ code has been implemented and optimized on intelplatform using 1920×1080 frame resolution to recognize the status of TLs during day-time and night-time scenes, achieving 95% precision and 94.7% recall at 30FPS.