gebhart/patrepeval huggingface dataset:
Carbon/PP composites and carbon/self-reinforced PP composites (2009)

Carbon reinforced thermoplastics represent an alternative to obtain light materials with high specific mechanical properties, avoiding intrinsic drawbacks of reinforced thermosets like long curing times and hazardous chemical substances. Furthermore, thermoplastic composites can also be re-melted, post-processed and recycled. In addition, due to its lightness, low-cost, and low Life Cycle Analysis impact, polypropylene is increasingly used as matrix thermoplastic composites.
A low-level explanation of paradoxical motion percepts (2010)

A recent series of experiments have demonstrated a deterioration of motion perception with increasing stimulus size for stimuli of high contrast (Tadin et al., 2003). This counterintuitive finding has been explained as a result of surround-suppression in visual area V5. Equally paradoxical was the finding that older observers appeared to show better motion perception than younger observers using the same technique (Betts et al., 2005). This second curious result was explained as a consequence of a reduction in V5 surround-suppression due to age-related changes in GABA-mediated inhibition. Using an opponent-motion stimulus, similar to that of previous studies but of constant duration, we have replicated the paradoxical effect of contrast on motion discrimination and also replicated the finding that this effect is much reduced or non-existent in older subjects. Our results can, however, be explained by low-level mechanisms: a proportional increase in the motion energy required to discriminate stimuli of progressively higher suprathreshold contrasts and spatial summation of motion in stimuli of progressively larger sizes. In previous studies, suprathreshold contrast co-varies with size, which may be responsible for the unusual results. TadinD.LappinJ. S.GilroyL. A.BlakeR. (2003). Perceptual consequences of centre-surround antagonism in visual motion processing. Nature, 424(6946), 312–315. Betts L. R. TaylorC. P.SekulerA. B.BennettP. J. (2005). Aging reduces center-surround antagonism in visual motion processing. Neuron, 45(3), 361–366.
Infection Is Not Required for Mucoinflammatory Lung Disease in CFTR-Knockout Ferrets (2018)

These findings implicate mucoinflammatory processes in the CF lung as pathogenic in the absence of clinically apparent bacterial and fungal infections.
Human periosteum-derived cells maintain phenotypic stability and chondrogenic potential throughout expansion regardless of donor age (2001)

Adult human PDCs have the potential to differentiate toward the chondrocytic lineage in vitro, retaining this property even after extensive subculture. Human PDCs are easily accessible, expandable, and maintain their chondrogenic potential, and are therefore promising progenitor cells for use in the repair of joint surface defects.
Search for a heavy Higgs boson decaying into two lighter Higgs bosons in the ττbb final state at 13 TeV (2021)

A bstract A search for a heavy Higgs boson H decaying into the observed Higgs boson h with a mass of 125 GeV and another Higgs boson h S is presented. The h and h S bosons are required to decay into a pair of tau leptons and a pair of b quarks, respectively. The search uses a sample of proton-proton collisions collected with the CMS detector at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 137 fb −1 . Mass ranges of 240–3000 GeV for m H and 60–2800 GeV for $$ {m}_{{\mathrm{h}}_{\mathrm{S}}} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msub> <mml:mi>m</mml:mi> <mml:msub> <mml:mi>h</mml:mi> <mml:mi>S</mml:mi> </mml:msub> </mml:msub> </mml:math> are explored in the search. No signal has been observed. Model independent 95% confidence level upper limits on the product of the production cross section and the branching fractions of the signal process are set with a sensitivity ranging from 125 fb (for m H = 240 GeV) to 2 . 7 fb (for m H = 1000 GeV). These limits are compared to maximally allowed products of the production cross section and the branching fractions of the signal process in the next-to-minimal supersymmetric extension of the standard model.
Linear Multiuser MIMO Transceiver Design With Quality of Service and Per-Antenna Power Constraints (2008)

Joint design of linear multiuser multiple-input-multiple-output (MIMO) transceiver subject to different quality of service (QoS) constraints per user and with per-antenna or antenna group power constraints is considered. Solutions for two linear transceiver optimization problems are proposed, i.e., balancing the weighted signal-to-interference-plus-noise ratio (SINR) per data stream and balancing the weighted rate for each scheduled user with minimum rate requirements per user. The proposed joint transceiver optimization algorithms are compared to corresponding optimal nonlinear transmission methods as well as to generalized zero-forcing transmission solutions. Unlike the optimal nonlinear schemes, the optimization problems employed in the linear multiuser MIMO transceiver design are not convex in general. However, the proposed algorithms are shown to provide very efficient solutions despite of the fact that the global optimum cannot be guaranteed due to nonconvexity of the problems.
CryoEM at Sanofi (2020)

We present our path to establish cryo-EM project support at Sanofi
Nanoparticle Superlattice Engineering with DNA (2011)

A current limitation in nanoparticle superlattice engineering is that the identities of the particles being assembled often determine the structures that can be synthesized. Therefore, specific crystallographic symmetries or lattice parameters can only be achieved using specific nanoparticles as building blocks (and vice versa). We present six design rules that can be used to deliberately prepare nine distinct colloidal crystal structures, with control over lattice parameters on the 25- to 150-nanometer length scale. These design rules outline a strategy to independently adjust each of the relevant crystallographic parameters, including particle size (5 to 60 nanometers), periodicity, and interparticle distance. As such, this work represents an advance in synthesizing tailorable macroscale architectures comprising nanoscale materials in a predictable fashion.
Ultrasound activated paclitaxel delivery in mice using a combined therapy and imaging probe system (2008)

Localized therapeutic effects of an experimental therapeutic agent on a mouse MC38 tumor model were evaluated using a combined ultrasound therapy and imaging probe system (TIPS). With ultrasound activated paclitaxel delivery, the tumor growth is substantially retarded for at least 3 days. The therapeutic effect of ultrasound is statistically significant (p=0.03) within one day after treatment but gradually decreases with time. Therefore, it is suggested that multiple treatments over a long period are required for cancer treatment. It is also demonstrated in this preclinical study that TIPS is an effective tool for imaging-guided, ultrasound-activated drug delivery.
Multidimensional Meta-Model Based Optimization of Optical Transmission Systems (2009)

We present a novel meta-model based optimization method for finding the optimum set of system parameters of an optical transmission system. Sampling points from the multidimensional parameter set are selected sparsely by Latin hypercube design, and for these points the signal quality at the receiver is evaluated by numerical simulations. Afterwards an interpolation function of the results is generated, and an optimization algorithm is carried out on this function to locate optima. Regions of interest can be identified and analyzed more precisely by further numerical simulations, which in turn improves the accuracy of the interpolation function. This iterative approach allows to localize the optimum parameter region efficiently with only a small fraction of the computational effort needed for a grid search.
Vickers Indentation Cracking of Ion-Exchanged Glasses: Quasi-Static vs. Dynamic Contact (2017)

The indentation deformation and cracking responses of ion-exchanged glasses were measured using quasi-static and dynamic loading cycles. Two glass types were compared, a normal glass that deforms to a large extent by a shearing mechanism and a damage resistant glass that comparatively deforms with less shear and more densification. The quasi-static indentation cracking threshold for median/radial cracks for the ion-exchanged normal glass was determined to be 7 kilograms force (kgf), while the ion-exchanged damage resistant glass required loads exceeding 30 kgf. The increased cracking threshold of the damage resistant glass composition is attributed to the deformation mechanism, i.e. deformation with greater densification/less shear results in less subsurface damage and less residual stress. Both glass types were also subjected to dynamic indentation where the contact event time was more than 10,000 times shorter than the quasi-static condition. Under dynamic loading conditions, the cracking thresholds of the ion-exchanged normal and damage resistant glasses increased to greater than 50 kgf and greater than 150 kgf, respectively. The stress induced optical retardation was compared for quasi-static and dynamic indents made at sub-cracking threshold loads for both glasses. For indents made at the same sub-cracking threshold load in the normal glass, optical retardation mapping indicates less residual stress surrounding dynamic indents when compared to quasi-static indents. This suggests a rate dependence on the deformation mechanism in normal glasses with higher rates promoting densification in favor of shear. However, for damage resistant glass, the stress induced optical retardation is the same for indents made at both quasi-static and dynamic indentation rates.
Search for a heavy charged boson in events with a charged lepton and missing transverse momentum from pp collisions at s=13  TeV with the ATLAS detector (2019)

A search for a heavy charged-boson resonance decaying into a charged lepton (electron or muon) and a neutrino is reported. A data sample of $139\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$ of proton-proton collisions at $\sqrt{s}=13\text{ }\text{ }\mathrm{TeV}$ collected with the ATLAS detector at the LHC during 2015--2018 is used in the search. The observed transverse mass distribution computed from the lepton and missing transverse momenta is consistent with the distribution expected from the Standard Model, and upper limits on the cross section for $pp\ensuremath{\rightarrow}{W}^{\ensuremath{'}}\ensuremath{\rightarrow}\ensuremath{\ell}\ensuremath{\nu}$ are extracted ($\ensuremath{\ell}=e$ or $\ensuremath{\mu}$). These vary between 1.3 pb and 0.05 fb depending on the resonance mass in the range between 0.15 and 7.0 TeV at 95% confidence level for the electron and muon channels combined. Gauge bosons with a mass below 6.0 and 5.1 TeV are excluded in the electron and muon channels, respectively, in a model with a resonance that has couplings to fermions identical to those of the Standard Model $W$ boson. Cross-section limits are also provided for resonances with several fixed $\mathrm{\ensuremath{\Gamma}}/m$ values in the range between 1% and 15%. Model-independent limits are derived in single-bin signal regions defined by a varying minimum transverse mass threshold. The resulting visible cross-section upper limits range between 4.6 (15) pb and 22 (22) ab as the threshold increases from 130 (110) GeV to 5.1 (5.1) TeV in the electron (muon) channel.
CRC Handbook of Laboratory Safety. 5th Edition By A. Keith Furr. CRC Press, Boca Raton, FL. 2000. xvii + 774 pp. 18 × 26 cm. ISBN 0-8493-2523-4. $149.99. (2001)

ADVERTISEMENT RETURN TO ISSUEPREVBook ReviewNEXTCRC Handbook of Laboratory Safety. 5th Edition By A. Keith Furr. CRC Press, Boca Raton, FL. 2000. xvii + 774 pp. 18 × 26 cm. ISBN 0-8493-2523-4. $149.99.Peter G. KlimkoView Author Information Alcon Research Ltd. 6201 South Freeway, MS R2-39 Ft. Worth, Texas 76134Cite this: J. Med. Chem. 2001, 44, 5, 849Publication Date (Web):January 30, 2001Publication History Published online30 January 2001Published inissue 1 March 2001https://pubs.acs.org/doi/10.1021/jm0005205https://doi.org/10.1021/jm0005205book-reviewACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views469Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Biomaterials,Chlorine,Explosives,Nitrogen,Safety Get e-Alerts
Expression of prostate-specific membrane antigen (PSMA) on circulating tumor cells (CTCs) in castration-resistant prostate cancer. (2014)

266 Background: Prostate-specific membrane antigen (PSMA) is expressed ubiquitously in prostate adenocarcinoma, and the intensity of expression increases with disease aggressiveness. Exploiting PSMA for therapy could potentially be aided by a minimally invasive means for measuring PSMA on tumor cells. Here we describe the development and characteristics of a novel assay for quantitating PSMA on canonical and non-canonical circulating tumor cells (CTCs). Methods: The PSMA CTC test was developed using LNCaP (high PSMA), 22Rv1 (low PSMA) and PC3 (no PSMA) cells spiked into normal blood. Nucleated blood cells were plated onto glass slides and subjected to immunofluorescent staining followed by CTC identification using the Pyxis Scanning Platform at Epic Sciences. The four-color assay evaluated PSMA expression on individual CTCs, identified as cells which are cytokeratin+, CD45-, and with an intact DAPI nucleus. Multiple antibody clones and assay conditions were evaluated, and the final PSMA CTC test has high specificity and sensitivity. Acceptance criteria included signal intensities in LNCaP versus PC3, subcellular localization of PSMA, and potential interference by a PSMA-targeted therapy. Clinical feasibility of the optimized assay was assessed on samples from CRPC patients. Results: The average PSMA signal intensity for LNCaP was 20-fold higher than that for PC3 and 10-fold higher than the minimum cutoff. PSMA displayed a predominantly membrane-localized pattern of staining that was distinct from cytokeratin. Assay performance was unaffected by the presence of PSMA ADC, a PSMA-targeted antibody-drug conjugate that is in phase II clinical testing. In feasibility tests on patient samples, the assay demonstrated utility in detecting and quantitating PSMA on individual and clustered CTCs as well as on apoptotic, cytokeratin-negative, and small cytokeratin-positive CTC candidates. Conclusions: PSMA expression was successfully detected and quantitated on diverse types of circulating cells present in the blood of patients with CRPC. Assay performance was unaffected by the presence of a PSMA-targeted therapeutic agent. PSMA CTC data are being collected in the ongoing phase II study of PSMA ADC for comparison with treatment outcomes.
Overexpression of ERBB2 in human mammary epithelial cells signals inhibition of transcription of the E-cadherin gene. (1994)

Overexpression of the ERBB2 receptor in transfectants of a human mammary epithelial cell line (MTSV1-7) is associated with a reduced ability to undergo morphogenesis in vitro and with a decreased level of expression of the E-cadherin and alpha 2 integrin genes. The inhibition of expression of the adhesion molecules has been shown to be at the level of transcription by using nuclear run-on assays and by following transcription of a reporter gene fused to 5' sequences of the E-cadherin gene. To relate the effects on gene transcription to a functional ERBB2 protein, signaling from the receptor was inhibited by the antibody 4D5, which blocks phosphorylation of ERBB2 on tyrosine residues and association of the protein with the GRB2/Sem5 protein. After treatment with the antibody 4D5, the ERBB2 transfectants regain the ability to form three-dimensional structures in collagen gels and the rates of transcription of the genes encoding the E-cadherin and the alpha 2 integrin subunit are restored to the levels seen in MTSV1-7neo cells. These results demonstrate that the inhibition of morphogenesis and transcription of specific adhesion molecules in human mammary epithelial cells can be affected by signals generated by the ERBB2 receptor and suggest a role for ERBB2 overexpression in tumor progression and metastasis.
Effects of molecular structure and thermal annealing on gas transport in two tetramethyl bisphenol‐A polymers (1988)

Abstract The effects of molecular structure and thermal history on the gas transport properties of tetramethyl bisphenol‐A polycarbonate (TMPC) and tetramethyl bisphenol‐A polysulfone (TMPSF) are reported. The presence of the bulky methyl side groups on the aromatic rings of TMPC and TMPSF inhibits both chain packing and molecular motions in these polymers as compared with standard polycarbonate and polysulfone. The methyl substitution results in significant increases in permeability with little or no loss of selectivity, making these materials promising candidates for membrane‐based gas separations applications. Thermal annealing produces a densification of the materials, resulting in decreased permeabilities. Selectivities remained roughly the same or increased slightly upon annealing at temperatures slightly below the glass transition temperature. Thus, thermal annealing may be useful for “fine‐tuning” a membrane's properties for applications where improved selectivity is desirable, even at the expense of decreased permeability.
On-the-Fly Communication-and-Computing for Distributed Tensor Decomposition Over MIMO Channels (2023)

Distributed tensor decomposition (DTD) is a fundamental data-analytics technique that extracts latent important properties from high-dimensional multi-attribute datasets distributed over edge devices. Conventionally its wireless implementation follows a one-shot approach that first computes local results at devices using local data and then aggregates them to a server with communication-efficient techniques such as over-the-air computation (AirComp) for global computation. Such implementation is confronted with the issues of limited storage-and-computation capacities and link interruption, which motivates us to propose a framework of on-the-fly communication-and-computing (FlyCom$^2$) in this work. The proposed framework enables streaming computation with low complexity by leveraging a random sketching technique and achieves progressive global aggregation through the integration of progressive uploading and multiple-input-multiple-output (MIMO) AirComp. To develop FlyCom$^2$, an on-the-fly sub-space estimator is designed to take real-time sketches accumulated at the server to generate online estimates for the decomposition. Its performance is evaluated by deriving both deterministic and probabilistic error bounds using the perturbation theory and concentration of measure. Both results reveal that the decomposition error is inversely proportional to the population of sketching observations received by the server. To further rein in the noise effect on the error, we propose a threshold-based scheme to select a subset of sufficiently reliable received sketches for DTD at the server. Experimental results validate the performance gain of the proposed selection algorithm and show that compared to its one-shot counterparts, the proposed FlyCom$^2$ achieves comparable (even better in the case of large eigen-gaps) decomposition accuracy besides dramatically reducing devices' complexity costs.
Non-volatile logic SoC with software-hardware co-design and integrated supply supervisor for energy harvesting applications (2017)

In a world where electronics is becoming increasingly ubiquitous, the challenge of powering devices is progressively becoming more difficult. Often it is impractical to replace batteries or line power numerous devices. Energy harvesting is an attractive alternative but has the inherent disadvantage of frequent power loss. For processing systems like microcontrollers (MCUs) power restoration usually requires a boot up sequence before the target application can start. Boot up negatively impacts the power budget and response time of a MCU. This paper describes how non-volatile memory can be used in an efficient manner to preserve the system state of a MCU. As a result, an application can continue operating from where it left off before the power loss, enabling compute through power loss. In contrast to previously published work, this work is a fully integrated SoC that automatically responds to an impending power loss. The MCU features an integrated supply supervisor with fail safe operation. A novel software synchronized state back-up process is also introduced, which drastically reduces the number of flops that need to be saved.
A range of catalytic efficiencies with avian retroviral protease subunits genetically linked to form single polypeptide chains. (1991)

Molecular modeling based on the crystal structure of the Rous sarcoma virus (RSV) protease dimer has been used to link the two identical subunits of this enzyme into a functional, single polypeptide chain resembling the nonviral aspartic proteases. Six different linkages were selected to test the importance of different interactions between the amino acids at the amino and carboxyl termini of the two subunits. These linkages were introduced into molecular clones of fused protease genes and the linked protease dimers were expressed in Escherichia coli and purified. Catalytically active proteins were obtained from the inclusion body fraction after renaturation. The linked protease dimers exhibited a 10-20-fold range in catalytic efficiencies (Vmax/Km) on peptide substrates. Both flexibility and ionic interactions in the linkage region affect catalytic efficiency. Some of the linked protease dimers were 2-3-fold more active than the nonlinked enzyme purified from bacteria, although substrate specificities were unchanged. Similar relative efficiencies were observed using a polyprotein precursor as substrate. Mutation of one catalytic Asp in the most active linked protease dimer inactivated the enzyme, demonstrating that these proteins function as single polypeptide chains rather than as multimers.