gebhart/patrepeval huggingface dataset:
AN EXPERIMENTAL STUDY ON FULL SCALE WOODEN FRAME RETROFITTED BY GLUED ADDITIONAL BRACES (2006)

In Japan, there are many old and historically valuable buildings. They should be preserved as cultural properties. Most of them, however, do not have enough seismic capacity according to the current building code. They need to be retrofitted but with minimum change to the original building, since they are cultural properties. A wooden building located in Zentsuji city, Kagawa, is nominated to be one of the national important cultural properties, but is evaluated that it does not have enough seismic capacity. In order to strengthen the building, a new retrofitting technique to glue new triangle frames into existing frames is proposed, and loading tests on full scale wooden frames are conducted to demonstrate the performance of the proposed technique. The test results shows that the proposed technique can increase effectively the strength and energy dissipation capability.
Fabrication and performance characteristics of black‐dielectric electroluminescent 160 × 80‐pixel displays (2004)

Abstract— We report on recent technological progress in black‐dielectric electroluminescent (BDEL) displays. Fabrication of the first monochrome BDEL 160 × 80‐pixel 4‐in. displays driven with commercial low‐power (&lt;5 W) drive circuitry is presented. Preliminary results on blue‐dielectric EL full‐color displays are also reported. Improvements in both BDEL display performance and display manufacturability underscore the recent development path.
Interpretation of Wall-mounted Probe Characteristics in Hall Thrusters (2008)

Peer Reviewed
Vaccines Linked to Chemotherapy: A New Approach to Control Helminth Infections (2012)

Currently, chemotherapy is the dominant application among the tools available for the control or elimination of human helminth infections. Single-drug agents are available for mass drug administration (MDA), but recent evidence suggests that some drugs previously thought to be effective now appear less so. Recent progress in vaccine development for human parasitic infections holds promise for the control of several diseases. While the goal of chemotherapy is to temporarily cure or reduce infection intensities, morbidity, and transmission, vaccines would also reduce worm burdens and, ideally, induce long-lasting protective host immune responses. In so doing, these vaccines might obviate the need for repeated MDA, and reduce the risk of both drug failure and reinfection. Some vaccines might also influence transmission through targeting the intermediate or reservoir host when the infection is zoonotic. Since biological targets are, in many cases, different from those of anthelmintic drugs, vaccination would also be synergistic with drug therapy. This would justify the use of effective vaccines as a long-term solution presently lacking in most of the control strategies. The repositioning of vaccines, to complement chemotherapy, would be a novel revitalizing concept to control activities that have remained focused on morbidity and/or transmission reduction. Antihelminth vaccines would thus aid in achieving the UN Millennium Development Goals regarding poverty reduction, education, and child and maternal health. The benefits of a new vaccine strategy would require long-term support and advocacy to maintain preclinical and clinical development.
Power-Independent Microwave Instantaneous Frequency Measurement Based on Combination of Brillouin Gain and Loss Spectra (2022)

Photonics-assisted microwave instantaneous frequency measurement (IFM) is considered as a promising technique for detecting an unknown radio-frequency (RF) signal, which has advantages of broad frequency measurement range and fast processing speed. Up to date, there is no photonics-assisted IFM system that can essentially measure an unknown RF signal time-frequency information with power fluctuating seriously. Moreover, the measurement accuracy and frequency modulation recognition are not as good as those of traditional electronic methods. Here, we propose an IFM scheme based on the combination of Brillouin gain spectrum (BGS) and Brillouin loss spectrum (BLS), which is RF-power-independent with high measurement efficiency. The combination of BGS and BLS to construct the amplitude comparison function (ACF) can reduce the influence of RF signal power fluctuation within 21.27 dB by single-shot measuring. When an appropriate frequency interval with frequency domain monotonous power of microwave comb signal is modulated on the pump lightwave, the IFM accuracy of the unknown signal reaches about 1 MHz. After the initial calibration of the system, it can recognize the time-frequency variation of single tone signal, linear frequency modulated signal (LFM), nonlinear frequency modulated signal (NLFM), and Costas signal. This scheme will help to promote the application of the IFM in the field of spectrum reconnaissance and reception.
Comparison of Prostate-Specific Membrane Antigen Expression Levels in Human Salivary Glands to Non-Human Primates and Rodents (2020)

<b><i>Background:</i></b> Prostate-specific membrane antigen (PSMA) has emerged as a promising target for developing radionuclide therapy (RNT) in prostate cancer; however, accumulation of PSMA-RNT in salivary glands can result in irreversible xerostomia. Methods to prevent PSMA-RNT-related xerostomia could be clinically useful; however, little is known about PSMA expression in salivary glands of preclinical animal models. Using [<sup>18</sup>F]DCFPyL autoradiography/biodistribution, PSMA expression levels were determined in salivary glands of various preclinical monkey and rodent species and compared with humans. <b><i>Methods:</i></b> Binding affinities (K<sub>d</sub>) and PSMA levels (B<sub>max</sub>) were determined by <i>in vitro</i> [<sup>18</sup>F]DCFPyL autoradiography studies. <i>In vivo</i> rodent tissue uptakes (%ID/g) were determined from [<sup>18</sup>F]DCFPyL biodistributions. <b><i>Results:</i></b> [<sup>18</sup>F]DCFPyL exhibited low nanomolar K<sub>d</sub> for submandibular gland (SMG) PSMA across all the species. PSMA levels in human SMG (B<sub>max</sub> = 60.91 nM) were approximately two-fold lower compared with baboon SMG but were two- to three-fold higher than SMG PSMA levels of cynomolgus and rhesus. Rodents had the lowest SMG PSMA levels, with the mouse being 10-fold higher than the rat. <i>In vivo</i> rodent biodistribution studies confirmed these results. <b><i>Conclusions:</i></b> SMG of monkeys exhibited comparable PSMA expression to human SMG whereas rodents were lower. However, the results suggest that mice are relatively a better small animal preclinical model than rats for PSMA salivary gland studies.
Frontal-Subcortical Circuits in Psychiatric and Neurological Disorders (2001)

Department of Medicine/Division of Neurology Pennsylvania State University College of Medicine Hershey, Pennsylvania
On the distinct differences in autonomic regulation between pregnant and non-pregnant women - a heart rate variability analysis (2023)

<i>Objective</i>. Appropriate adaptation of the maternal autonomic nervous system to progressing gestation is essential to a healthy pregnancy. This is partly evidenced by the association between pregnancy complications and autonomic dysfunction. Therefore, assessing maternal heart rate variability (HRV)-a proxy measure for autonomic activity-may offer insights into maternal health, potentially enabling the early detection of complications. However, identifying abnormal maternal HRV requires a thorough understanding of normal maternal HRV. While HRV in women of childbearing age has been extensively investigated, less is known concerning HRV during pregnancy. Subsequently, we investigate the differences in HRV between healthy pregnant women and their non-pregnant counterparts.<i>Approach</i>. We use a comprehensive suite of HRV features (assessing sympathetic and parasympathetic activity, heart rate (HR) complexity, HR fragmentation, and autonomic responsiveness) to quantify HRV in large groups of healthy pregnant (<i>n</i>= 258) and non-pregnant women (<i>n</i>= 252). We compare the statistical significance and effect size of the potential differences between the groups.<i>Main results</i>. We find significantly increased sympathetic and decreased parasympathetic activity during healthy pregnancy, along with significantly attenuated autonomic responsiveness, which we hypothesize serves as a protective mechanism against sympathetic overactivity. HRV differences between these groups typically had a large effect size (Cohen's<i>d</i>> 0.8), with the largest effect accompanying the significantly reduced HR complexity and altered sympathovagal balance observed in pregnancy (Cohen's<i>d</i>> 1.2).<i>Significance</i>. Healthy pregnant women are autonomically distinct from their non-pregnant counterparts. Subsequently, assumptions based on HRV research in non-pregnant women cannot be readily translated to pregnant women.
[Occurrence of PFOA and PFOS in the aquatic environments and their ecological toxicities in the aquatic environments]. (2011)

Based on current researches, described the sources, toxicities, analytical methods and occurrence of PFOA and PFOS in wastewater treatment plants, lakes, rivers, coastal areas and tap waters in different countries in the world. According to the limited concentrations of PFOA + PFOS in effluents of wastewater treatment plants (WTPs) put forward by Germany, the concentrations of PFOA + PFOS in WTP effluents in Singapore, Germany, Korea and England were assessed. The results showed that the concentrations of PFOA + PFOS in WTP effluents in Singapore were higher than the liminted concentration of 300 microg/L. Researches done by China, Japan, USA, and other countries showed that the concentrations of POFA and PFOS in rivers and coastal areas reached to ng/L, and the concentrations in Tennessee River, USA were the highest, reached to 100 ng/L. The risk assessments of PFOA and PFOS in tap water in some cities in China were assessed according to the risk quotients(RQ). The assessment results showed that tap waters from 19 cities in China were all below the risk level.
The neural substrates of recollection and familiarity (1999)

Aggleton &amp; Brown argue that a hippocampal-anterior thalamic system supports the “recollection” of contextual information about previous events, and that a separate perirhinal-medial dorsal thalamic system supports detection of stimulus “familiarity.” Although there is a growing body of human literature that is in agreement with these claims, when recollection and familiarity have been examined in amnesics using the process dissociation or the remember/know procedures, the results do not seem to provide consistent support. We reexamine these studies and describe the results of an additional experiment using a receiver operating characteristic (ROC) technique. The results of the reanalysis and the ROC experiment are consistent with Aggleton &amp; Brown's proposal. Patients with damage to both regions exhibit severe deficits in recollection and smaller, but consistent, deficits in familiarity.
The Capsular Polysaccharide ofBurkholderia pseudomalleiContributes to Survival in Serum by Reducing Complement Factor C3b Deposition (2005)

Burkholderia pseudomallei produces an extracellular polysaccharide capsule -3)-2-O-acetyl-6-deoxy-beta-D-manno-heptopyranose-(1- which has been shown to be an essential virulence determinant. The addition of purified capsule was shown to increase the virulence of a capsule mutant strain in the Syrian hamster model of acute melioidosis. An increase in the number of wild-type B. pseudomallei cells in the blood was seen by 48 h, while the number of capsule mutant cells in the blood declined by 48 h. Capsule expression was shown to be induced in the presence of serum using a lux reporter fusion to the capsule gene wcbB. The addition of purified B. pseudomallei capsule to serum bactericidal assays increased the survival of B. pseudomallei SLR5, a serum-sensitive strain, by 1,000-fold in normal human serum. Capsule production by B. pseudomallei contributed to reduced activation of the complement cascade by reducing the levels of complement factor C3b deposition. An increase in phagocytosis of the capsule mutant compared to the wild type was observed in the presence of normal human serum. These results suggest that the production of this capsule contributes to resistance to phagocytosis by reducing C3b deposition on the surface of the bacterium, thereby contributing to the persistence of bacteria in the blood of the infected host. Continued studies to characterize this capsule are essential for understanding the pathogenesis of B. pseudomallei infections and the development of preventive strategies for treatment of this disease.
An Audio-Based Wakeword-Independent Verification System (2020)

We propose an audio-based wakeword-independent verification model to determine whether a wakeword spotting model correctly woke and should respond or incorrectly woke and should not respond. Our model works on any wakeword-initiated audio, independent of the wakeword by operating only on the audio surrounding the wakeword, yielding a wakeword agnostic model. This model is based on two key assumptions: that audio surrounding the wakeword is informative to determine if the user intended to wake the device and that this audio is independent of the wakeword itself. We show experimentally that on wakewords not included in the training set, our model trained without examples or knowledge of the wakeword is able to achieve verification performance comparable to models trained on 5,000 to 10,000 annotated examples of the new wakeword.
PLM Software Selection Model for Project Management Using Hierarchical Decision Modeling With Criteria From PMBOK® Knowledge Areas (2014)

Abstract:This article presents a methodology for product lifecycle management (PLM) software selection utilizing the nine knowledge areas of the Project Management Body of Knowledge (PMBOK®) (A Guide to the Project Management Body of Knowledge (PMBOK® Guide, 2008). The methodology utilizes a five-process gate approach where the PLM offerings are researched, sorted, paired down, evaluated, and implemented. The primary decision model utilizes hierarchical decision modeling (HDM). Prioritizations are assigned to the PMBOK® knowledge areas utilizing a pair-wise comparison survey and then assessed across the different PLM system offerings. The proposed decision methodology is meant to serve only as a guide to assist with selection of PLM software from a project management perspective. To validate the model, several applications are presented that apply the selection methodology to different industries: semiconductor, information technology (IT), and automotive supply.Keywords:: Project ManagementPMBOKProduct Life-Cycle ManagementProduct DevelopmentProgram ManagementHierarchical Decision ModelingSoftware Selection
2-Output Spin Wave Programmable Logic Gate (2020)

This paper presents a 2-output Spin-Wave Programmable Logic Gate structure able to simultaneously evaluate any pair of AND, NAND, OR, NOR, XOR, and XNOR Boolean functions. Our proposal provides the means for fanout achievement within the Spin Wave computation domain and energy and area savings as two different functions can be simultaneously evaluated on the same input data. We validate our proposal by means of Object Oriented Micromagnetic Framework (OOMMF) simulations and demonstrate that by phase and magnetization threshold output sensing {AND, OR, NAND, NOR} and {XOR and XNOR} functionalities can be achieved, respectively. To get inside into the potential practical implications of our approach we use the proposed gate to implement a 3-input Majority gate, which we evaluate and compare with state of the art equivalent implementations in terms of area, delay, and energy consumptions. Our estimations indicate that the proposed gate provides 33% and 16% energy and area reduction, respectively, when compared with spin-wave counterpart and 42% energy reduction while consuming 12x less area when compared to a 15 nm CMOS implementation.
Recommendations for the use of rituximab (anti‐CD20 antibody) in the treatment of autoimmune bullous skin diseases§ (2008)

Autoimmune bullous skin disorders are induced by autoantibodies against distinct adhesion complexes of the epidermal and dermal-epidermal junction. Since most of these disorders are characterized by a severe, potentially lethal course,they require long-term immunosuppressive treatment to reduce the de novo synthesis of pathogenic autoantibodies by B lymphocytes. Rituximab, a chimeric monoclonal antibody against CD20 on B lymphocytes, has shown promise in several case reports or cohort studies in the treatment of paraneo-plastic pemphigus,refractory cases of pemphigus vulgaris and foliaceus and in other autoimmune bullous disorders. Treatment with rituximab leads to depletion of pathogenic B-cells which may last up to 12 months resulting in a reduction of plasma cells secreting pathogenic autoantibodies. Rituximab is usually administered in an adjuvant setting at a dose of 375 mg/m(2) i.v.in weekly intervals for four consecutive weeks in addition to the standard immunosuppressive treatment. The present consensus statement of German-speaking dermatologists, rheumatologists and oncologists summarizes and evaluates the current evidence for the use and mode of application of rituximab in autoimmune bullous skin disorders.
High efficiency electrospun TiO2nanofiber based hybrid organic–inorganic perovskite solar cell (2013)

The good electrical and morphological characteristics of TiO₂ nanofibers and the high extinction coefficient of CH₃NH₃PbI₃ perovskite are combined to obtain a solar cell with a power conversion efficiency of 9.8%. The increase of the film thickness dramatically diminishes the performance due to the reduction in porosity of the TiO₂ nanofiber framework. The optimum device (∼413 nm film thickness) is compared to a planar device, where the latter produces higher V(oc) but lower J(sc), and consequently lower efficiency at all measured light intensities.
Hot Topic Sensing, Text Analysis, and Summarization (2014)

Social monitoring platforms are software services that enable the rapid analysis of massive amounts of information (mostly text messages) expressed in social networks. Their usage today mostly focuses on marketing industries that need to reach their customers in a proper way. In the e-government domain, however, such tools have mostly been used by political parties as a support to election campaigns, but few have been actually used to provide a comprehensive understanding of the citizens' needs in everyday life. In this chapter, the authors present a set of data analytics tools that can help public authorities to extract and summarize textual content from Internet forums and social media feeds. There are many potential applications of these tools, such as the visualization of the main political discussion in the city, early detection of disagreement with the local politics, and city services connected to social media.
130  Safety, β-sarcoglycan expression and functional outcomes from systemic gene transfer of rAAVrh74.MHCK7.SGCB in LGMD2E/R4 (2022)

Limb-girdle muscular dystrophy type 2E/R4 (LGMD2E/R4) is caused by β-sarcoglycan (SGCB) gene mutations, resulting in loss of functional protein and dystrophin-associated protein complex disruption. LGMD2E/R4 symptoms include hip/shoulder muscle weakness, cardiac involvement, and elevated creatine kinase (CK). Here, we report initial findings of a Phase 1/2 open-label, systemic gene transfer trial ( NCT03652259 ) of rAAVrh74.MHCK7.hSGCB (SRP-9003), designed to restore functional SGCB, in patients with LGMD2E/R4. Six patients (aged 4–15 years, negative for rAAVrh74 antibodies, 100-meter timed test &gt;40%) received a single SRP-9003 IV infusion of 1.85×1013 vg/kg (Cohort 1, n=3) or 7.41×1013 vg/kg (Cohort 2, n=3). Prednisone (1 mg/kg/day) was initiated 1 day before (30–60 days taper). Endpoints: safety (primary), SGCB expression (secondary), others: North Star Assessment of Limb-girdle Muscular Dystrophies (NSAD), timed functional tests. SRP-9003 is well tolerated with no unexpected immunologic responses observed. All patients demonstrated efficient transduction and robust SGCB expression post-infusion, with subsequent sarcoglycan complex reconstitution and CK reduction. Six months after SRP-9003 infusion, both patient cohorts experienced functional improvements. Cohort 1 had data available up to 18 months indicating NSAD and timed test improvements were maintained over time. These data suggest long-term efficacy of SRP-9003 gene-transfer therapy, supporting advancement of the clinical development program. jrichardson@sarepta.com 90
Frequency Channelization and Afterwards Processing (2016)

Channelization is one of the most important operations in building digital electronic warfare (EW) receivers. The equivalent analog operation is the filter bank. Therefore digital channelization can be considered a digital filter bank. It can also be considered as an N-port network with one input and N - 1 outputs. An input signal will appear at a certain output according to its frequency. By measuring the outputs from the filter bank, the frequency of the input signal can be determined. The only practical approach to building a wideband digital EW receiver with today&apos;s technology is through channelization. A common method of performing channelization is by employing the fast Fourier transform (FFT). To build a receiver using FFT, the length and the overlap of the FFT are very important parameters. These parameters are related to the minimum pulse width (PW) and the frequency resolution, which determines the sensitivity of the receiver. The frequency information can be obtained from the outputs of the digital filters. In order to obtain the input frequency, the filter outputs must be further processed. The main objectives of a receiver are to determine the number of input signals and their frequencies. The circuit used to accomplish these goals is referred to as the encoder. The encoding circuit is the most difficult subsystem to design in an EW receiver and most research effort is spent on the encoder design. This is true for both digital and analog receivers. The main problems are to avoid the generation of false alarms and the detection of weak signals. In an analog filter bank, the shape of the filter is difficult to control, and it is difficult to build filters with uniform performance, such as bandwidth and ripple factor, therefore the encoder must accommodate this problem. The shape of each individual filter in a digital filter bank can be better controlled. As a result, the encoder should be slightly easier to design because it does not need to compensate for the filter differences. Because of the complexity of the encoder, its design will not be discussed in detail. The design of a specific digital filter bank will also be presented. This specific example is used to illustrate the design procedure while avoiding the unnecessary mathematical complexity of a general design. In this example, the concepts of polyphase filters and multirate operation are introduced. In order to understand these concepts, decimation and interpolation are discussed first.