gebhart/patrepeval huggingface dataset:
Practical Dynamic Searchable Encryption with Small Leakage (2014)

Dynamic Searchable Symmetric Encryption (DSSE) enables a client to encrypt his document collection in a way that it is still searchable and efficiently updatable.However, all DSSE constructions that have been presented in the literature so far come with several problems: Either they leak a significant amount of information (e.g., hashes of the keywords contained in the updated document) or are inefficient in terms of space or search/update time (e.g., linear in the number of documents).In this paper we revisit the DSSE problem.We propose the first DSSE scheme that achieves the best of both worlds, i.e., both small leakage and efficiency.In particular, our DSSE scheme leaks significantly less information than any other previous DSSE construction and supports both updates and searches in sublinear time in the worst case, maintaining at the same time a data structure of only linear size.We finally provide an implementation of our construction, showing its practical efficiency.
Quantitative Assessment of Cefuroxime: A Second Generation Cephalosporin in Pharmaceutical Formulations and Spiked Plasma Using Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry (2014)

A simple and rapid method has been developed for the determination of cefuroxime in pharmaceutical formulations and spiked plasma. The method involves the application of ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for the quantitative assessment of cefuroxime. The chromatographic separation of the cefuroxime was carried out using BEH C18 column (100 mm 2.1 mm, 1.7 m particle size) using a binary mobile phase mixture of 1-octane sulfonic acid sodium salt (5.78 10 -4 M) and acetonitrile (50:50, v/v) at a flow rate of 0.5 mL min -1 . The UPLC-MS/MS have shorter analysis time of 1 min was found to be linear over the concentration range of 0.5-5 g mL -1 . Limit of detection and limit of quantitation of the UPLC-MS/MS method was obtained to be 0.10 and 0.301 g mL -1 . The method was validated as per the ICH guidelines. The recovery studies suggest an excellent recovery of the procedure which was found in the range of 99.94-100.47 % for the pharmaceutical formulation and 95.63 to 96.89 %. for the spiked plasma. The RSD range of the developed analytical procedure ranged from 0.90 %-1.68 % in intra-day studies and 1.42 %-1.97 %, respectively.
New histone deacetylase inhibitors improve cisplatin antitumor properties against thoracic cancer cells (2014)

// Fabien Gueugnon 1,2,3 , Pierre-Fran&ccedil;ois Cartron 1,2,3,4 , Cedric Charrier 5 , Philippe Bertrand 4,5 , Jean-Fran&ccedil;ois Fonteneau 1,2,3 , Marc Gregoire 1,2,3 and Christophe Blanquart 1,2,3,4 1 Inserm, U892, F-44000, Nantes, France 2 CNRS, UMR6299, F-44000, Nantes, France 3 Universit&eacute; Nantes, F-44000, Nantes, France 4 R&eacute;seau Epig&eacute;n&eacute;tique du Cancerop&ocirc;le Grand Ouest 5 CNRS, UMR7285, Institut de Chimie des Milieux et Mat&eacute;riaux de Poitiers, Universit&eacute; de Poitiers, France Correspondence: Christophe Blanquart1, email: // Keywords : Mesothelioma, lung cancer, chemotherapy and epigenetic Received : April 2, 2014 Accepted : June 1, 2014 Published : June 3, 2014 Abstract Histone deacetylase inhibitors (HDACi) have shown promising antitumor effects on numerous cancer cells including malignant pleural mesothelioma (MPM) and lung adenocarcinoma (ADCA) cells. However, clinical trials using these compounds alone have shown limited efficacy against solid tumors. Therefore, new molecules are being developed and combinations with classical chemotherapeutic drugs are being tested. Here, we have evaluated on three MPM and three lung ADCA cell lines the antitumor potential of four new HDACi compounds, either alone or in combination with cisplatin. These effects were compared with those of vorinostat, an HDACi approved for cancer treatments. First, we characterized the HDAC mRNA expression profiles of tumor cells and showed an increase of the classI/classII HDAC ratio. We then treated cancer cells with these new HDACi and observed a cell-death induction and an increase of HDACi target genes and proteins expression. This was particularly evident for NODH compound (pan-HDACi) which had similar effects at nanomolar concentrations as micromolar concentrations of vorinostat. Interestingly, we observed that the HDACi/cisplatin combination strongly increased cell-death and limited resistance-phenotype emergence as compared with results obtained when the drugs were used alone. These results could be exploited to develop MPM and lung ADCA treatments combining chemotherapeutic approaches.
Integer forward differencing of cubic polynomials (1991)

Two incremental cubic interpolation algorithms are derived and analysed. Each is based on a known linear interpolation algorithm and modified for third order forward differencing. The tradeoff between overflow avoidance and loss of precision has made forward differencing a method which, although known to be fast, can be difficult to implement. It is shown that there is one particular family of curves which represents the worst case, in the sense that if a member of this family can be accurately drawn without overflow, then any curve which fits in the bounding box of that curve can be. From this the limitations in terms of step count and screen resolution are found for each of the two algorithms.
Oracle database filesystem (2011)

Modern enterprise, web, and multimedia applications are generating unstructured content at unforeseen volumes in the form of documents, texts, and media files. Such content is generally associated with relational data such as user names, location tags, and timestamps. Storage of unstructured content in a relational database would guarantee the same robustness, transactional consistency, data integrity, data recoverability and other data management features consolidated across files and relational contents. Although database systems are preferred for relational data management, poor performance of unstructured data storage, limited data transformation functionalities, and lack of interfaces based on filesystem standards may keep more than eighty five percent of non-relational unstructured content out of databases in the coming decades.We introduce Oracle Database Filesystem (DBFS) as a consolidated solution that unifies state-of-the-art network filesystem features with relational database management ones. DBFS is a novel shared-storage network filesystem developed in the RDBMS kernel that allows content management applications to transparently store and organize files using standard filesystem interfaces, in the same database that stores associated relational content. The server component of DBFS is based on Oracle SecureFiles, a novel unstructured data storage engine within the RDBMS that provides filesystem like or better storage performance for files within the database while fully leveraging relational data management features such as transaction atomicity, isolation, read consistency, temporality, and information lifecycle management. We present a preliminary performance evaluation of DBFS that demonstrates more than 10TB/hr throughput of filesystem read and write operations consistently over a period of 12 hours on an Oracle Exadata Database cluster of four server nodes. In terms of file storage, such extreme performance is equivalent to ingestion of more than 2500 million 100KB document files a single day. The set of initial results look very promising for DBFS towards becoming the universal storage solution for both relational and unstructured content.
Efficiency enhancement of solid-state PbS quantum dot-sensitized solar cells with Al2O3 barrier layer (2013)

Atomic layer deposition (ALD) was used to grow both PbS quantum dots and Al2O3 barrier layers in a solid-state quantum dot-sensitized solar cell (QDSSC). Barrier layers grown prior to quantum dots resulted in a near-doubling of device efficiency (0.30% to 0.57%) whereas barrier layers grown after quantum dots did not improve efficiency, indicating the importance of quantum dots in recombination processes.
Development of a Gas Turbine Combustor Utilizing a Catalyst (1979)

Catalytically supported thermal combustion has been successfully incorporated into a low-pressure-r atio gas turbine type system. Excellent emissions performance was obtained utilizing gaseous propane fuel. A combustor design concept has been developed that is applicable to gaseous fueled gas turbine engines. A working solution to the important questions related to the use of this type of combustor in a dynamic turbine environment has been demonstrated for low-pressure-ratio simple-cycle engines. Both straight-through flow and reverse-flow combustors have been developed for use in conjunction with the catalyst system. Fuel turndown ranges approximating 10:1 have been achieved in both systems tested, the range being limited in this instance by the machine airflow capacity. For systems of the type discussed herein, increases in combustor diameters no greater than 50% with respect to conventional combustors would be required for low-pressure-ratio engine applications. A prime goal for high-pressure-ratio applications is the development of short residence time mixing configurations.
A Chopper-Stabilized Amplifier With a Relaxed Fill-In Technique and 22.6-pA Input Current (2023)

In chopper amplifiers, the interaction between the input signal and the chopper clock can cause intermodulation distortion (IMD). This is mainly due to finite amplifier bandwidth, which causes signal-dependent output spikes at the chopping transitions. Such chopper-induced IMD can be mitigated by the fill-in technique, which involves ping-ponging between the outputs of two identical OTAs chopped in quadrature, thus generating a spike-free output. In this work, a relaxed implementation is proposed in which the output of a fill-in OTA is only briefly used to avoid the spikes of a chopped main OTA. As a result, the fill-in OTA does not need to be chopped, and so it can be duty-cycled to save power. Furthermore, the chopper ripple caused by the main OTA can now be suppressed by a single low-noise ripple-reduction loop, rather than the two AZ loops required in a previous ping-pong implementation of the fill-in technique. Compared to the latter, the proposed amplifier achieves similar IMD performance (-125.7dB), a 25× lower input current (22.6pA) and a flat noise floor (12 nV/Hz).
Synthesis of Gaussian beams in the near-field of linear arrays (2010)

In this paper we optimized a ten element linear infinitesimal dipole array for the near-field generation of a Gaussian beam. The amplitude and phase weights on the linear dipole array are optimized via a genetic algorithm to provide the closest match to a Gaussian profile. A Gaussian profile is synthesized at a distance of 0.5 wavelengths to 50 wavelengths away from the broadside of the antenna system.
THE PAYNE EFFECT: PRIMARILY POLYMER-RELATED OR FILLER-RELATED PHENOMENON? (2019)

ABSTRACT The hysteretic softening at small dynamic strains (Payne effect)—related to the rolling resistance and viscoelastic losses of tires—was studied as a function of particle size, filler volume fraction, and temperature for carbon black (CB) reinforced uncrosslinked styrene–butadiene rubber (SBR) and a paste-like material composed of CB-filled paraffin oil. The low-strain limit for dynamic storage modulus was found to be remarkably similar for CB-filled oil and the CB-filled SBR. Small-angle X-ray scattering (SAXS) measurements on the simple composites and detailed data analysis confirmed that the aggregate structures and nature of filler branching/networking of carbon black were virtually identical within oil compared to the high molecular weight polymer matrix. The combined dynamic rheology and SAXS results provide clear evidence that the deformation-induced breaking (unjamming) of the filler network—characterized by filler–filler contacts that are percolated throughout the material—is the main cause for the Payne effect. However, the polymer matrix does play a secondary role as demonstrated by a reduction in Payne effect magnitude with increasing temperature for the CB-reinforced rubber, which was not observed to a significant extent for the oil–CB system.
GM'S RICK LEE HAS A NEW, STRATEGIC APPROACH TO THE FLEET MARKET. (1996)

SUBTITLE: RICK LEE WAS APPOINTED EXECUTIVE DIRECTOR OF GM'S CONSOLIDATED FLEET OPERATION IN FEBRUARY 1996: SINCE THEN, LEE HAS CONCENTRATED ON FURTHER UTILIZING INFORMATION TECHNOLOGY, CREATING A FLEET ADVISORY COUNCIL, AND MUCH MORE.
Colloidal nanocrystals with near-infrared optical properties : synthesis, characterization, and applications (2011)

Colloidal nanocrystals with optical properties in the near-infrared (NIR) are of interest for many applications such as photovoltaic (PV) energy conversion, bioimaging, and therapeutics. For PVs and other electronic devices, challenges in using colloidal nanomaterials often deal with the surfaces. Because of the high surface-to-volume ratio of small nanocrystals, surfaces and interfaces play an enhanced role in the properties of nanocrystal films and devices. Organic ligand-capped CuInSe2 (CIS) and Cu(InXGa 1-X)Se2 (CIGS) nanocrystals were synthesized and used as the absorber layer in prototype solar cells. By fabricating devices from spray-coated CuInSe nanocrystals under ambient conditions, solar-to-electric power conversion efficiencies as high as 3.1% were achieved. Many treatments of the nanocrystal films were explored. Although some treatments increased the conductivity of the nanocrystal films, the best devices were from untreated CIS films. By modifying the reaction chemistry, quantum-confined CuInSe XS2-X (CISS) nanocrystals were produced. The potential of the CISS nanocrystals for targeted bioimaging was demonstrated via oral delivery to mice and imaging of nanocrystal fluorescence. The size-dependent photoluminescence of Si nanocrystals was measured. Si nanocrystals supported on graphene were characterized by conventional transmission electron microscopy and spherical aberration (Cs)-corrected scanning transmission electron microscopy (STEM). Enhanced imaging contrast and resolution was achieved by using Cs-corrected STEM with a graphene support. In addition, clear imaging of defects and the organic-inorganic interface was enabled by utilizing this technique.
Small sized band 20 SAW duplexer using low acoustic velocity Rayleigh SAW on LiNbO<inf>3</inf> substrate (2017)

Small sized surface acoustic wave (SAW) devices with high performances have been strongly demanded. In order to fulfill these requirements, we have developed a small sized temperature compensated SAW (TC-SAW) duplexer. The die size of current SAW devices highly depends on the size of interdigital transducers (IDTs) which is proportional to the acoustic velocity of the SAW. Therefore, we tried to lower the acoustic velocity of the Rayleigh SAW on LiNbO3 (LN) substrates, which is widely used for TC-SAW devices. In order to lower the acoustic velocity, we adopted multi layered IDT electrodes of Pt and Al, and increased the thickness of the Pt layer. From both several calculations and experimental results of one port resonators, the thickness of the Pt layer where the target acoustic velocity can be derived was determined, and the cut angle of LN substrates was optimized so as to minimize a spurious response. Moreover, good characteristics of high quality factor (Q-factor) and small temperature coefficient of frequency (TCF) were experimentally confirmed. Finally, by using this low acoustic velocity Rayleigh SAW, we successfully realized a small sized SAW duplexer for Band 20, which is 19 % smaller than the conventional one, maintaining high performances.
Compact boiling refrigerant-type cooling unit using multi-stacked radiator cores for automobiles (2000)

We have developed a new closed two-phase loop thermosyphon with multi-stacked radiator cores and a new flow controller which forms refrigerant circulation. The features are: (1) more compact and lighter weight than heat pipe cooling units, (2) cooling performance can be easily adjusted by the number of radiator cores according to heat dissipation quantity. © 2000 Scripta Technica, Heat Trans Asian Res, 29(8): 634–647, 2000
Structure‐Aware Mesh Decimation (2015)

Abstract We present a novel approach for the decimation of triangle surface meshes. Our algorithm takes as input a triangle surface mesh and a set of planar proxies detected in a pre‐processing analysis step, and structured via an adjacency graph. It then performs greedy mesh decimation through a series of edge collapse, designed to approximate the local mesh geometry as well as the geometry and structure of proxies. Such structure‐preserving approach is well suited to planar abstraction, i.e. extreme decimation approximating well the planar parts while filtering out the others. Our experiments on a variety of inputs illustrate the potential of our approach in terms of improved accuracy and preservation of structure.
Old proteins, developing roles: The regulation of calcium channels by synaptic proteins (2008)

Coupling of presynaptic voltage-gated calcium channels to the synaptic release machinery is critical for neurotransmission. It was traditionally believed that anchoring calcium channels close to the calcium microdomain dependent release machinery was the main reason for the physical interactions between channels and synaptic proteins, however in recent years, it is becoming clear that these proteins additionally regulate channel activity, and such processes as channel targeting and alternative splicing, to orchestrate a much broader regulatory role in controlling calcium channel function, calcium influx and hence neurotransmission. Calcium signalling serves a multitude of cellular functions and therefore requires tight regulation. Specific, often calcium-dependent interactions between synaptic proteins and calcium channels appear to play a significant role in fine-tuning of the synaptic response over development. While it is clear that investigation of a few of the multitude of synaptic proteins will not provide a complete understanding of calcium channel regulation, consideration of the emerging mechanisms by which synaptic protein interactions might regulate calcium channel function is important in order to understand their possible contributions to synaptic transmission. Here, we review the current state of knowledge of the molecular mechanisms by which synaptic proteins regulate presynaptic calcium channel activity.
Processus ponctuels et réseaux de neurones convolutifs pour la détection de véhicules dans des images de télédétection (2021)

National audience
[O2–03–03]: TAU‐INDUCED NEURODEGENERATION IS MEDIATED BY RNA BINDING PROTEINS (2017)

The classic model of protein aggregation posits that aggregation of tau occurs as a random event. However, this model over-looks emerging the biology of RNA binding proteins (RBPs) and tau in producing RNA granules, which control RNA metabolism. RBPs readily aggregate through a tightly regulated mechanism involving liquid-liquid phase separation. Mutations in RBPs linked to neurological diseases increase the propensity of RBPs to aggregate, which can become irreversible with time. Recent cell culture studies show that the association of tau with RBPs promotes tau aggregation, while reducing T cell intracellular antigen 1 (TIA1), a core nucleating RBP, protects against tau-mediated toxicity. PS19 P301S tau mice were crossed with TIA1-/- to generate P301S tau x TIA1+/- and P301S tau x TIA1 -/- mice. Reducing TIA1 levels in vivo strongly protects against neurodegeneration and prolongs survival. PS19 x TIA1+/- mice exhibit a 26% increase in lifespan. The protection is associated with rescue of deficits in RNA metabolism, including a striking decrease in the number of cytoplasmic stress granules, a corresponding increase in nuclear TIA1, and rescue of dysfunctional RNA splicing. There is a correspondingly increased binding of tau to microtubules and microtubule stabilization. The mice show strongly improved neuronal/brain function, including protection against synaptic and neuronal loss, and improved spatial working memory. Remarkably, this protection occurs despite increased neurofibrillary tangles. Biochemical studies show that PS19 x TIA1+/- mice exhibit a striking reduction of soluble tau oligomers with a corresponding increase in levels of insoluble tau fibrils. These results point to dysfunction of RBPs and RNA metabolism as important factors contributing to tauopathy. We propose a new paradigm in which tau pathology is (in part) driven by the role of tau in the translational stress response, which is mediated by the interaction with RBPs and RNA granules. Excess aggregation of RBPs produces pathological stress granules, which promote tau aggregation and cause RNA metabolism dysfunction. Tau / RBPs interactions appear to enhance the accumulation of tau in an oligomeric state that is more toxic than fibrillar tau. These results suggest that RBPs could provide compelling targets for therapeutic development.
A Framework for Speech Enhancement With Ad Hoc Microphone Arrays (2016)

Speech enhancement is vital for improved listening practices. Ad hoc microphone arrays are promising assets for this purpose. Most well-established enhancement techniques with conventional arrays can be adapted into ad hoc scenarios. Despite recent efforts to introduce various ad hoc speech enhancement apparatus, a common framework for integration of conventional methods into this new scheme is still missing. This paper establishes such an abstraction based on inter and intra subarray speech coherencies. Along with measures for signal quality at the input of subarrays, a measure of coherency is proposed both for subarray selection in local enhancement approaches, and also for selecting a proper global reference when more than one subarray are used. Proposed methods within this framework are evaluated with regard to quantitative and qualitative measures, including array gains, the speech distortion ratio, the PESQ measure, and the STOI intelligibility measure. Major findings in this work are the observed changes in the superiority of different methods for certain conditions. When perceptual quality or intelligibility of the speech are the ultimate goals, there are turning points where the MVDR and the LCMV are superior to Wiener-based methods. Also, for certain scenarios, local approaches may be preferred to global ones.
Dionysius: A Framework for Modeling Hierarchical User Interactions in Recommender Systems (2017)

We address the following problem: How do we incorporate user item interaction signals as part of the relevance model in a large-scale personalized recommendation system such that, (1) the ability to interpret the model and explain recommendations is retained, and (2) the existing infrastructure designed for the (user profile) content-based model can be leveraged? We propose Dionysius, a hierarchical graphical model based framework and system for incorporating user interactions into recommender systems, with minimal change to the underlying infrastructure. We learn a hidden fields vector for each user by considering the hierarchy of interaction signals, and replace the user profile-based vector with this learned vector, thereby not expanding the feature space at all. Thus, our framework allows the use of existing recommendation infrastructure that supports content based features. We implemented and deployed this system as part of the recommendation platform at LinkedIn for more than one year. We validated the efficacy of our approach through extensive offline experiments with different model choices, as well as online A/B testing experiments. Our deployment of this system as part of the job recommendation engine resulted in significant improvement in the quality of retrieved results, thereby generating improved user experience and positive impact for millions of users.