gebhart/patrepeval huggingface dataset:
Fungal Secondary Metabolism (2012)

Definition: Fungal secondary metabolites (SMs) comprise a vast collection of compounds expendable&#13;\nfor these organisms under laboratory conditions. They exhibit enormous chemical diversity, and usu-&#13;\nally belong to four major families: terpenoids, polyketides, non-ribosomal peptides, or a combination&#13;\nof the last two. Their functions are very diverse and are normally associated with a greater fitness&#13;\nof the producing fungi in their environment, which often compete with other microorganisms or&#13;\ninteract with host plants. Many SMs have beneficial applications, e.g., as antibiotics or medical drugs,&#13;\nbut others, known as mycotoxins, are harmful to health.
Percutaneous Costoclavicular Bypass for Thoracic Outlet Syndrome and Cephalic Arch Occlusion in Hemodialysis Patients (2019)

The percutaneous costoclavicular bypass is a feasible option for thoracic outlet and cephalic arch occlusion in symptomatic dialysis patients.
Sobre os notoriamente superestimados poderes da voz na ficção ou: como falhar ao conversar com garotas bonitas = The notoriously overestimated powers of ‘voice’ in fiction, or: how to fail in talking to pretty girls (2015)

Explorando o conceito de “voz na ficção”, o artigo de D. W. Wilson reflete sobre suas possíveis interpretações, focando principalmente na voz-enquantofalada e na voz-enquanto-escrita. Além desses dois conceitos, mais abrangentes, há a voz do escritor, que lê o texto; a simulação da voz falada do escritor, presente no artigo escrito; a voz que escutamos na mente, ao ler um texto em silêncio; e a voz enquanto estilo ou identidade do texto, geradora da intimidade entre literatura e leitor. Acompanhando o ensaio, Bernardo Bueno oferece uma nota introdutória sobre o contexto histórico e pessoal do artigo, e também sobre o processo da tradução da voz, como complemento do artigo original de Wilson
Scanning of a Dissipative Kerr-Microresonator Soliton Comb for Direct Optical Frequency Comb Spectroscopy (2019)

Direct optical frequency comb spectroscopy (DFCS), which enables ultra-precise and high resolution spectroscopy, is one of the most significant applications of optical frequency combs. With the discovery of dissipative Kerr soliton combs from microresonators (Kerr soliton combs), Kerr soliton combs became compatible with chip-scale DFCS systems. However, DFCS based on Kerr soliton combs is more involved than DFCS with conventional frequency combs. This is because Kerr soliton combs typically have a mode spacing of at least tens of GHz and allow only for a small detuning range between pump laser frequency and a resonance of the microresonator. Hence the pump laser frequency needs to be carefully scanned simultaneously with the FSR of the microresonator, which is very challenging [1]. In this report, we propose a new method to overcome this difficulty with fixing the detuning, even while scanning the FSR of a microresonator. In the proposed method, a feedback loop based on Pound-Drever-Hall (PDH) locking is employed.
In Vitro and In Vivo Synergy of Fosmidomycin, a Novel Antimalarial Drug, with Clindamycin (2002)

Fosmidomycin acts through inhibition of 1-deoxy-D-xylulose 5-phosphate (DOXP) reductoisomerase, a key enzyme of the nonmevalonate pathway of isoprenoid biosynthesis. It possesses potent antimalarial activity in vitro and in murine malaria. In a recent clinical study, fosmidomycin was effective and well tolerated in the treatment of patients with acute uncomplicated Plasmodium falciparum malaria but resulted in an unacceptably high rate of recrudescence. In order to identify a potential combination partner, the interaction of fosmidomycin with a number of antimalarial drugs in current use was investigated in a series of in vitro experiments. Synergy was observed between fosmidomycin and the lincosamides, lincomycin and clindamycin. The efficacy of a combination of fosmidomycin and clindamycin was subsequently demonstrated in the Plasmodium vinckei mouse model.
MURI: Electrochemically-Controlled Orthogonal Assembly of Monolayers on a Gold Surface via DPN (2003)

Abstract : Nature utilizes molecular recognition between complex macromolecules to form sophisticated meso- and macroscopic architectures with tremendous control over the placement and orientation of nanoscopic building blocks within the extended architectures. The structures of proteins, duplex DNA, and phospholipid bilayers are maintained by cumulative weak and reversible interactions (hydrogen bonding and van der Waals interactions), and pairing principles for the constituent molecules. The biosyntheses are remarkably efficient, self-correcting, and high yielding; therefore, they are excellent models for how the synthetic chemist should consider designing complex nanostructured materials. The specific objective of the proposed research was to demonstrate orthogonal assembly of charged particles by electrochemically controlling particle deposition. In addition, the use of applied potentials to selectively miniaturize microscopic features to nanoscopic dimensions was explored.
Towards a controlled patterning of 10 nm silicon gates in high density plasmas (2005)

International audience
Distributed cooperative spectrum sensing from sub-Nyquist samples for Cognitive Radios (2015)

Distributed collaborative spectrum sensing has been considered for Cognitive Radio (CR) in order to cope with fading and shadowing effects that affect a single CR performance, without the communication overhead of centralized cooperation through a fusion center. In this paper, we consider collaborative spectrum sensing by a distributed network of CRs from sub-Nyquist samples to overcome the sampling rate bottleneck of the wideband signals a CR usually deals with. We present a joint reconstruction algorithm, Randomized Distributed Simultaneous Iterative Hard Thresholding (RDSIHT) that adapts the original IHT to block sparse and matrix (simultaneous) inputs, as well as distributed collaboration settings. An observation vector is passed around the network as a random walk process, and updated at each iteration by one of the CRs. Simulations show that our algorithm outperforms a distributed collaborative scheme based on the One-Step Greedy Algorithm (OSGA) using randomized gossip, and that its performance converges to that of its centralized version.
Computer Analysis of Spectrum Anomaly in 32-GHz Traveling-Wave Tube for Cassini Mission (1999)

Computer modeling of the 32-GHz traveling-wave tube (TWT) for the Cassini Mission was conducted to explain the anomaly observed in the spectrum analysis of one of the flight-model tubes. The analysis indicated that the effect, manifested as a weak signal in the neighborhood of 35 GHz, was an intermodulation product of the 32-GHz drive signal with a 66.9-GHz oscillation induced by coupling to the second harmonic'signal. The oscillation occurred only at low- radiofrequency (RF) drive power levels that are not expected during the Cassini Mission. The conclusion was that the anomaly was caused by a generic defect inadvertently incorporated in the geometric design of the slow-wave circuit and that it would not change as the TWT aged. The most probable effect of aging on tube performance would be a reduction in the electron beam current. The computer modeling indicated that although not likely to occur within the mission lifetime, a reduction in beam current would reduce or eliminate the anomaly but would do so at the cost of reduced RF output power.
Optimal file sharing in distributed networks (2002)

Given a distributed network of processors represented by an undirected graph G=(V, E) and a file size k, the problem of distributing an arbitrary file w of k bits among all nodes of the network G is considered. Memory devices are to be assigned to the node of G such that, by accessing the memory of its own and of its adjacent nodes, each node can reconstruct the contents of w. The objective is to minimize the total size memory in the network. A file distribution scheme that realizes this objective for k>>log Delta /sub G/, where Delta /sub G/, stands for the maximum degree in G, is presented. For this range of k, the total size of memory required by the suggested scheme approaches an integer programming lower bound on that size.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Meeting report on the Ninth Conference on Cancer Therapy with Antibodies and Immunoconjugates. (2003)

This conference, held biennially for the past 12 years, provides a forum where investigators from throughout the world can gather and discuss how monoclonal antibodies can be used to improve the treatment of cancer. As in the past, this meeting focused primarily on the use of radiolabeled antibodies in cancer treatment, but this year there were many additional contributions on the use of unconjugated "naked" antibodies for the treatment of cancer, reflecting a growing understanding that antibodies not only can be used to direct isotopes and drugs to tumors but can also be effective agents in themselves. Preclinical studies using immunoconjugates prepared with toxins, drugs, or other agents were also reported to be highly effective therapeutic agents. Some of these are now showing efficacy in clinical trials. In addition, presentations focused on a variety of approaches, including pretargeting, regional delivery, and combinations with other standard treatment regimens designed to optimize antibody-targeted treatment strategies. Although the most efficacious treatments were reported in a variety of hematological malignancies, there were a number of presentations, primarily in early preclinical development, that provided evidence for potential future improvements in the treatment of solid tumors.
Potential for two isoforms of the A1 ribonucleoprotein in Xenopus laevis. (1990)

We have identified the Xenopus cognates for the RNA-binding protein A1. This protein has previously been shown to be one of the components of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex in rat and human cells. We have isolated several Xenopus clones from oocyte, tailbud embryo, and leg muscle cDNA libraries and determined their nucleotide sequences. Potentially, two different A1 isoforms are expressed in Xenopus; they have been termed XA1a and XA1b. Besides insertions and deletions, the XA1a protein sequence is 92% identical to the rat protein and suggests very similar secondary structures. There are two segments in the COOH-terminal domain where deletions or insertions are apparent: the rat protein does not have a 48-residue sequence that is present in the frog protein, and the frog protein does not have a 12-residue sequence that is present in the rat protein. We have confirmed that the XA1a protein is larger than rat A1 by in vitro transcription, translation, and gel electrophoresis. The second isoform, XA1b, is very similar to the XA1a isoform, except it has a different COOH terminus due to the absence of a 73-nucleotide region from its cDNA clones. Transcripts representing both isoforms have been detected in various Xenopus RNA preparations by polymerase chain reaction experiments with A1-specific oligonucleotides. Our findings suggest that the isoforms are encoded by one or two genes and are the result of alternative splicing. We discuss the biological implications of having two forms of the A1 component of hnRNP particles.
A Class of Lossless, Reciprocal Anti-Sidetone Networks for Telephone Sets (1980)

Anti-sidetone networks are used in telephone sets to interconnect the transmitter, receiver, and telephone line. Most passive networks used in modern telephone instruments belong to the class of lossless, reciprocal networks known as maximum output networks. This paper defines a larger class of lossless, reciprocal networks suitable for use as anti-sidetone networks in telephone sets and describes the properties of the networks belonging to this class. The class includes maximum output networks, such as those conventionally used for this application, as well as certain nonmaximum output networks. The latter, although they do not exhibit maximum power transfer characteristics at all network ports, have the same transmit and receive power transfer ratios as the maximum output networks. The network presently used in the Trimline® telephone set is an example of a nonmaximum output network belonging to this class. The use of such a network provides a convenient method of biasing the LEDs which are used to illuminate the dial in this telephone set. However, the power transfer characteristics between the transmitter, receiver, and telephone line ports of this network are the same as those of a conventional maximum output network.
Development of Immunogenic Tumor-Loaded Dendritic Cells Through Physical Perturbation and Apoptotic Cell Loading (2008)

To improve understanding of the forces that drive monocytes to transition into dendritic cells (Liyanage et al., 2002), we developed an experimental system that converts monocytes to DC by passage of leukocytes through a 400 microm silica bead column. The results demonstrate that overnight culture of column-treated monocytes causes a phenotypic conversion that is characteristically displayed by immature DC. These phenotypic changes were enhanced when the DC were loaded with apoptotic cells, leading to increased expression of the DC maturation-associated markers CD83, CD80 and the chemokine receptor CCR7. The DC demonstrated potent induction of allogeneic T cell proliferation and the capacity to activate autologous CD8(+) T cells. The CD8 T cells expressed augmented levels of perforin, IFN-gamma and TNF-alpha and mediated CTCL cell apoptosis. These studies demonstrate that physical contact with silica beads combined with loading of apoptotic tumor cells induces synchronized, rapid conversion of human monocytes to DC, which can efficiently stimulate CD8(+) T cells. These results may aid in the development of more efficient DC vaccines that can be loaded with the universe of antigens available in apoptotic tumor cells in a rapid, clinically practical fashion.
A Prescriptive Stock Market Investment Strategy for the Restaurant Industry using an Artificial Neural Network Methodology (2019)

Stock price forecasting is a classic problem facing analysts. Forecasting models have been developed for predicting individual stocks and stock indices around the world and in numerous industries. According to a literature review, these models have yet to be applied to the restaurant industry. Strategies for forecasting typically include fundamental and technical variables. In this research, fundamental and technical inputs were combined into an artificial neural network (ANN) stock prediction model for the restaurant industry. Models were designed to forecast 1 week, 4 weeks, and 13 weeks into the future. The model performed better than the benchmark methods, which included, an analyst prediction, multiple linear regression, trading, and Buy and Hold trading strategies. The prediction accuracy of the ANN methodology presented reached accuracy performance measures as high as 60%. The model also shown resiliency over the housing crisis in 2008.
A software defined radio realization of a multimedia HDTV receiver (2009)

DVB-T2, the revision of DVB-T (Terrestrial Digital Video Broadcasting), was recently finalized, targeting to high definition television (HDTV). To pave the way to commercialization, an appropriate implementation concept and its corresponding validation are of utmost importance. Without a doubt, the most challenging requirements introduced by the DVB-T2 specification are an FFT (Fast Fourier Transform) size of up to 32 k samples, 256-QAM (Quadrature Amplitude Modulation) and LDPC (Low-Density Parity-Check) coding with a block size of 64 k bits. In this manuscript, the authors present a software defined radio realization concept, comprising a combined DSP (Digital Signal Processor) and FPGA (Field Programmable Gate Array) solution, which is tailored to meet these requirements.
I giorni della Memoria e del Ricordo. I viaggi di formazione nelle scuole toscane come Public History of Education (2019)

The construction of social cadres of memory is a process that is linked to the selection and oblivion of historical events, through a collective narrative aiming at building a sense of belonging and citizenship. Is it possible to get rid of public exploitation and travel through the places of 20th Century history to activate a path of correct historicization?
Viscosity drives texture perception of protein beverages more than hydrocolloid type (2019)

Hydrocolloids are added to alter rheological properties of beverages but have other properties that can contribute to overall taste and texture perception. In this study, tapioca starch and λ-carrageenan were used to determine how hydrocolloid type, viscosity level (4-6 mPa·s, 25-30 mPa·s, and 50-60 mPa·s at 50 s<sup>-1</sup> ), and complexity of the system (aqueous, skim milk, or whole milk) influence sensory taste and texture of fluids. All fluids were shear thinning; however, skim milk and whole milk solutions that contained carrageenan had much higher low shear viscosity and lower high shear viscosity than those with starch. There was a significant effect of viscosity level on sensory perception of consistency, creamy/oily, mouthcoating, and residual mouthcoating in aqueous, skim milk, and whole milk beverages, and a weak effect of hydrocolloid type. However, normalizing creamy/oily, paste, and mouthcoating against sensory consistency removed the effect of hydrocolloid type. Flavors (cream, cooked, cardboard, and melon/cardboard) were associated with the type of hydrocolloid and milk protein ingredient. Temporal dominance of sensations showed that samples exhibit similar temporal sensory profiles, although the addition of hydrocolloids enhanced dominance of creaminess even in samples without fat. Hydrocolloid type did not significantly influence mouthcoating or the persistence of astringency. Additionally, increasing viscosity from 3 to 74 mPa·s at 50 s<sup>-1</sup> did not suppress perceived sweet or salty taste. The results suggest that in fluid systems with viscosity levels typically found in beverages, textural properties are determined by viscosity and independent of the type of hydrocolloid.
Method of using deuterium-cluster foils for an intense pulsed neutron source (2023)

A method is provided for producing neutrons, comprising: providing a converter foil comprising deuterium clusters; focusing a laser on the foil with power and energy sufficient to cause deuteron ions to separate from the foil; and striking a surface of a target with the deuteron ions from the converter foil with energy sufficient to cause neutron production by a reaction selected from the group consisting of D-D fusion, D-T fusion, D-metal nuclear spallation, and p-metal. A further method is provided for assembling a plurality of target assemblies for a target injector to be used in the previously mentioned manner. A further method is provided for producing neutrons, comprising: splitting a laser beam into a first beam and a second beam; striking a first surface of a target with the first beam, and an opposite second surface of the target with the second beam with energy sufficient to cause neutron production.
P1523Impact of device orientation on device-device communication between a leadless pacemaker and a subcutaneous implantable cardioverter-defibrillator in an acute and chronic setting (2017)

Introduction: Implantation of dual-chamber pacemaker is the treatment of choice in severe and/or symptomatic bradycardia. Purpose: The purpose of this study was to evaluate the prognostic importance of baseline characteristics of consecutive patients at the time of DDD pacemaker implantation on their survival. Methods: All consecutive patients (3932) in whom DDD pacing system was implanted in the period between the first DDD implantation in October 1984 and the last implantation in December 2014 were retrospectively followed up until 31 August 2016. The study group consisted of 3924 patients in whom the survival was assessed on 31 August 2016 in the central national database. The patients' mean age at the time of implantation was 69.87 6 12.13 (15.27 -96.65) years; 53.7% were male; 2610 (66.5%) had sick sinus syndrome (SSS), 1314 (33.5%) had atrioventricular block (AVB) defined as second-degree AVB (736 pts) and complete AVB (549 pts) or bundle branch block with syncope (28 pts). The endpoint was all-cause mortality. Results: During follow-up 1433 (36.5%) patients died. After 1, 5, 10, 15, 20 years after implantation 95%, 82%, 62%, 46%, 31% of patients remained in follow-up. AVB was present in 871 (41.3%) men and 468 (25.8%) women, whereas SSS was present in 1237 (58.7%) men and 1347 (74.2%) women (Chi2; P0.0000). Women were older at the time of implantation than men (70.6 vs 69.2 years) (U Mann-Whitney; P0.000258). Furthermore, patients with AVB were younger than patients with SSS at the time of implantation (68.8 6 13.7 vs 70.4 6 11.2 years; U Mann-Whitney; P0.0212). Additionally, women lived longer after DDD pacemaker implantation than men (7.9 vs 7.4 years) (log-rank; P0.0000) and had longer overall survival (log-rank; P0.0000). There was no significant difference in the mortality between patients with AVB and SSS (Chi2; P0.1220). However, patients with AVB lived 7.2 6 5.5 years after implantation, whereas patients with SSS 7.8 6 5.1 years (U Mann-Whitney; P0.0000). In Cox-proportional hazard model only age at implantation (HR1.075, 95% CI 1.069-1.082; P0.0000) and male gender (HR1.406, 95%, CI 1.264-1.563; P0.0000) were the predictors of mortality. Conclusions: In this study we show that women have longer survival after DDD pacemaker implantation than men in spite of an older age at the time of implantation. Furthermore, we do not observe significant difference in mortality between patients with AVB and SSS.
Latest results from the Nikon NSR-S620 double patterning immersion scanner (2009)

Double patterning (DP), an extension of immersion, is the leading contender for the manufacturing of 32 nm half pitch node devices. For DP, substantial improvement in overlay accuracy is required to meet the CDU requirements for the 32 nm node, and substantial increase in throughput is required to meet the cost requirements. To meet these challenges, Nikon introduced the NSR-S620. The S620 is based on the <i>Streamlign</i> platform, which is characterized by three innovations: <i>Bird's Eye Control, Stream Alignment, and Modular<sup>2</sup> Structure</i>. In addition, many of the current systems and techniques have been refined to meet the requirements for DP. This presentation will discuss these technological improvements and show the latest technical results.
Rate-Splitting Multiple Access for 6G—Part II: Interplay With Integrated Sensing and Communications (2022)

This letter is the second part of a three-part tutorial focusing on rate-splitting multiple access (RSMA) for 6G. As Part II of the tutorial, this letter addresses the interplay between RSMA and integrated radar sensing and communications (ISAC). In particular, we introduce a general RSMA-assisted ISAC architecture, where the ISAC platform has a dual capability to simultaneously communicate with downlink users and probe detection signals to a moving target. Then, the metrics of radar sensing and communications are respectively introduced, followed by a RSMA-assisted ISAC waveform design example which jointly minimizes the Cramér-Rao bound (CRB) of target estimation and maximizes the minimum fairness rate (MFR) amongst communication users subject to the per-antenna power constraint. The superiority of RSMA-assisted ISAC is verified through simulation results in both terrestrial and satellite scenarios. RSMA is demonstrated to be a powerful multiple access and interference management strategy for ISAC, and provides a better communication-sensing trade-off compared with the conventional benchmark strategies. Consequently, RSMA is a promising technology for next generation multiple access (NGMA) and future networks such as 6G and beyond.
Proceedings of the 21st International Teletraffic Congress (2009)

International audience