gebhart/patrepeval huggingface dataset:
Supplementary document for High dimensional frequency crystals in electro-optic microcombs - 4674796.pdf (2020)

Supplementary document
Artificial intelligence in computer graphics (2004)

article Artificial intelligence in computer graphics: a constructionist approach Share on Authors: Kristinn R. Thórisson Communicative Machines Communicative MachinesView Profile , Christopher Pennock Communicative Machines Communicative MachinesView Profile , Thor List Communicative Machines Communicative MachinesView Profile , John DiPirro Communicative Machines Communicative MachinesView Profile Authors Info & Claims ACM SIGGRAPH Computer GraphicsVolume 38Issue 1February 2004 pp 26–30https://doi.org/10.1145/1012272.1012275Published:01 February 2004 6citation1,004DownloadsMetricsTotal Citations6Total Downloads1,004Last 12 Months28Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Minimizing outage probability for arbitrary channel distributions (2005)

MIMO wireless systems have been a focus of research for several years, mainly because of the promise of increased channel capacity, extended range, and increased reliability. An aspect of this ongoing research has been concerned with transmit precoding given partial information of the channel. This work focuses on designing a transmit covariance to minimize the probability of outage for a given target data rate over a fading MIMO channel whose distribution is known to the transmitter. This problem is addressed by formulating a convex problem via a heuristic relaxation. Structure of the problem is utilized to simplify the numerical implementation. Finally, the performance of this technique relative to other simpler techniques is considered, therefore showing the utility of this computational technique in evaluating other heuristics.
Demonstration of stable and high coupling efficiency (66%) active multi-mode interferometer superluminescent light emitting diodes (2010)

High power superluminescent light emitting diodes, using active multi-mode interferometer, showed high coupling efficiency of 66% into single-mode fiber, which resulted in maximum coupled power of 77 mW (λ center =1.55 μm, FWHM = 50 nm).
Role of the WWOX fragile gene in cancer (2007)

LB-107 The WW domain-containing oxidoreductase (WWOX) encodes a 46kDa protein that contains two N-terminal WW domains and central short-chain dehydrogenase/reductase (SDR) -like domain. The WWOX gene spans the second most active common fragile site, FRA16D; a region that shows frequent loss-of heterozygosity, and is associated with homozygous deletions in various adenocarcinomas and with chromosomal translocations in multiple myeloma. Indeed, WWOX expression is altered in a large fraction of many cancer types including breast, prostate, lung, stomach and pancreatic carcinomas. Therefore, it has been suggested that loss of WWOX expression in several cancer types is due mainly to its location within FRA16D and might be a secondary event not associated with tumorigenesis. Our recent observations, however, indicate that loss of WWOX expression in human tumors contributes to their pathogenesis. Early evidence that WWOX might be capable of suppressing tumor growth came from overexpression studies. Restoration of WWOX in cancer cells lacking expression of endogenous WWOX results in significant growth inhibition and prevents the development of tumors in athymic nude mice. To provide direct in vivo evidence that WWOX is a tumor suppressor, we generated mice carrying a targeted deletion of the Wwox gene. The murine Wwox locus is similar to its human homolog, spans the Fra8E1 common fragile site, and is highly conserved. We demonstrate that the loss of both alleles of Wwox results in osteosarcomas in some early postnatal mice, while loss of one allele significantly increases the incidence of spontaneous lung papillary carcinomas. In addition, higher incidence and multiplicity of ethyl nitrosourea (ENU) and N-nitrosomethylbenzylamine (NMBA)-induced tumors were formed in Wwoxheterozygous mice compared to wild type mice. Intriguingly, some of these tumors still express Wwox protein, suggesting haploinsuffiency of Wwox itself is cancer predisposing. Our findings indicate that WWOX is a bona fide tumor suppressor and that inactivation of one Wwox allele, a condition that frequently occurs due to the fragility of the WWOX locus and the high incidence of LOH observed in WWOX gene in many human cancer types, is sufficient for tumorigenesis.
Coded Excitation and Annular Arrays for High-Frequency Ultrasound Imaging (2006)

High-frequency ultrasound (HFU) shows promises for with fine-resolution imaging. However, the limited depth of field (DOF) and penetration depth of HFU waves mitigates in significance for clinical evaluation. The aim of this study is to use modern annular transducer technology and coded excitation to simultaneously improve DOF and penetration depth. A 20-MHz, five-element annular array with a focal length of 18 mm and a total aperture of 6 mm was custom made using a 25-microm thick polyvinylidene fluoride membrane. The annular array was excited by a 8-micros coded signal to image a phantom made of seven regularly spaced 25-microm wire. The coded signal was a chirp linearly spanning the frequency range to 40 MHz. Results of this study demonstrate that the DOF can be improved by factor of 3 and signal-to-noise ratio (SNR) can improved by more than 24 dB with coded-excitation methodologies. The increased SNR offers the potential to increase the penetration depth when imaging in vivo.
Vibration of Double Cable Suspension Bridge under Vehicle Load (2011)

A single moving mass-spring-damper model is adopted to simulate the vehicle model. The equation of vehicle-bridge coupling vibration is derived, using D'Alembert principle and the conditions of displacement compatibility. The dynamic responses of a double cable suspension bridge to the vehicle moving at different speeds are analyzed, considering the geometric nonlinearity and the bridge carriageway irregularity factor, under two types of vehicle loading conditions, namely moving along the center and the eccentric longitudinal axis. Then the influence of vehicle velocity and bridge carriageway irregularity on impact coefficient of double cable suspension bridge is discussed. Single cable suspension bridge can be taken as a special case of double cable suspension bridge, after the main cable shape coefficient is introduced. The dynamic responses of double cable suspension bridge and single cable suspension bridge are compared to reveal the character of vehicle vibration of double cable suspension bridge. The study of the dynamic responses character of double cable suspension bridge has a positive significance on structural form selection of such type bridge during designing, dynamic performance evaluation and vibration control.
Astigmatic Wavefront Correction Of A Gain-Guided Laser Diode Array Using Anamorphic Diffractive Microlenses (1988)

A diffractive microlens array was used to collimate a one-dimensional array of gain-guided AlGaAs lasers. The astigmatism of the lasers was removed by using anamorphic microlenses. The Strehl ratio of the resulting wavefront was 0.98. The microlens array was placed in an external cavity to produce a single coherent diffraction-limited beam from the AlGaAs laser array.
OS0605 A Study on Very High Cycle Fatigue Properties of High Cleanliness Spring steel (2011)

In order to investigate the very high cycle fatigue properties of high cleanliness valve spring steel, rotating bending fatigue tests were performed by means of dual-spindle rotating bending fatigue testing machine. Fracture surfaces of failed specimens were observed by a scanning electron microscope (SEM) and fracture mechanisms of this material were discussed from view points of fractography and fracture mechanics. As results, it was found that the interior-initiated fracture would occur even for specimens without non-metallic inclusions inside the material. This fact suggests that the interior clack takes place at a certain kind of microstructural defect.
Raloxifene preserves bone strength and bone mass in ovariectomized rats. (1994)

We investigated the effects of raloxifene, a nonsteroidal benzothiophene, on bone strength in ovariectomized rats and compared them with estrogen treatment. Sixty ovariectomized Sprague-Dawley rats were divided into three groups for treatment with orally dosed raloxifene (3 mg/kg), ethynyl estradiol (EE, 0.1 mg/kg), or vehicle. A fourth group of 20 rats that underwent sham ovariectomies and received vehicle was used for comparison. Treatments began 3 days after ovariectomy and continued for 6 months. Raloxifene treatment resulted in greater bone strength in the lumbar vertebrae (P < 0.05) and femoral neck (P < 0.01) and greater bone mineral density at the proximal tibia (P < 0.001) and lumbar vertebrae (P < 0.001) when compared with vehicle-treated ovariectomized animals. The positive effects on bone biomechanical properties from raloxifene treatment were not different than those associated with EE treatment. Raloxifene did not cause a significant increase in uterine weight, whereas EE treatment resulted in uterine weight increased 4-fold over vehicle-treated ovariectomized controls. Therefore, in rats, raloxifene has beneficial effects on bone biomechanics that are equivalent to those of EE treatment without substantial effects on the uterus.
Pair Reactions, Rearrangements and Formation of Alkenes from Radicals (1995)

This chapter contains sections titled: Radical Pairs Radical Rearrangements Alkene-Forming Reactions References
Cellular-Broadcast Service Convergence through Caching for CoMP Cloud RANs (2015)

Cellular and Broadcast services have been traditionally treated independently due to the different market requirements, thus resulting in different business models and orthogonal frequency allocations. However, with the advent of cheap memory and smart caching, this traditional paradigm can converge into a single system which can provide both services in an efficient manner. This paper focuses on multimedia delivery through an integrated network, including both a cellular (also known as unicast or broadband) and a broadcast last mile operating over shared spectrum. The subscribers of the network are equipped with a cache which can effectively create zero perceived latency for multimedia delivery, assuming that the content has been proactively and intelligently cached. The main objective of this work is to establish analytically the optimal content popularity threshold, based on a intuitive cost function. In other words, the aim is to derive which content should be broadcasted and which content should be unicasted. To facilitate this, Cooperative Multi- Point (CoMP) joint processing algorithms are employed for the uni and broad-cast PHY transmissions. To practically implement this, the integrated network controller is assumed to have access to traffic statistics in terms of content popularity. Simulation results are provided to assess the gain in terms of total spectral efficiency. A conventional system, where the two networks operate independently, is used as benchmark.
Recombinant human uteroglobin suppresses cellular invasiveness via a novel class of high-affinity cell surface binding site. (1996)

The mechanism(s) that regulates invasion of trophoblasts through the uterine epithelium during embryo implantation and nidation in hemochorial placental mammals is poorly understood. While limited trophoblast invasion is essential for the establishment of normal pregnancy, dysregulation of this process may contribute to the pathogenesis of choriocarcinoma, a highly invasive and lethal form of cancer arising from the trophoblasts. We have previously demonstrated that rabbit uteroglobin (UG), a cytokine-like, antiinflammatory protein, produced by the endometrial epithelium during pregnancy, has a potent antichemotactic effect on neutrophils and monocytes in vitro. Here, we report that recombinant human UG (hUG) dramatically suppresses invasion of human trophoblasts and NIH 3T3 cells through an artificial basement membrane (Matrigel) in vitro but has no effect on that of human choriocarcinoma cells. We identified a previously unreported high-affinity, high molecular weight (approximately 190 kDa), nonglycosylated hUG-binding protein, readily detectable on human trophoblasts and NIH 3T3 cells but totally lacking on choriocarcinoma cells. Taken together, these results raise the possibility that (i) hUG plays a critical role in regulating cellular invasiveness, at least in part, via its previously unrecognized cell surface binding site, and (ii) some of the numerous biological activities of proteins of the UG family, reported so far, may be mediated via this binding site.
Heterogeneous Ziegler-Natta Catalyst Based on Neodymium for the Stereospecific Polymerization of Butadiene (2001)

International audience
Non-thermal, pulsed electric field cell ablation: A novel tool for regenerative medicine and scarless skin regeneration (2013)

High voltage, short pulsed electric fields (PEF) is a non-thermal ablation method, in which defined PEF irreversibly destabilize cell membranes, while preserving other tissue components such as the extracellular matrix (ECM). In the present report, we show that PEF ablated rat skin retains its microvascular blood supply and ECM structure. Complete regeneration of epidermis, hair follicles, sebaceous glands, and the panniculus carnosusis observed two months after the ablation. Our results clearly indicate that non-thermal PEF has the potential to be a powerful and novel tool for scarless tissue regeneration.
Development of a Cellular Biochip Mimicking in Vitro Organs for Chronic Toxicity Analysis (2007)

MDCK, HepG2/C3a, HepaRG and bone marrow cells were used as liver, kidney and bone model respectively inside a PDMS biochip. Healthy culture conditions during 96 hours, including 72 hours of perfusion were demonstrated by the cell proliferation (MDCK, HepG2) and basic metabolism activities (HepaRG, bone marrow). An example of chronic toxicity was performed by using ammonia chloride loadings that have reduced the proliferation of the MDCK.
Detection of Activated STAT5 in the Cytoplasm of Neoplastic Cells in Patients with AML, CML, and Systemic Mastocytosis. (2006)

Abstract The signal transducer and activator of transcription 5 (STAT5) has recently been implicated as essential pro-oncogenic factor in the pathogenesis of myeloid leukemias in mice (Cancer Cell2005;7:87–99). More recently, STAT5 activation has also been described to occur in human leukemias. However, so far, little is known about the expression of activated/tyrosine phosphorylated STAT5 (pSTAT5) in various myeloid neoplasms and about the distribution of pSTAT5 in the cellular compartments of the normal and leukemic bone marrow (bm). We have examined the expression of pSTAT5 in the bm in patients with acute myeloid leukemia (AML, FAB M0, n=3, M1, n=6, M2, n=4, M3, n=5, M4, n=5, M5, n=4, M6, n=5, M7, n=4), chronic myeloid leukemia (CML, chronic phase, n=4, accelerated phase, n=5, blast phase, n=5), and systemic mastocytosis (SM, n=30), as well as in the normal bm (n=5). Expression of pSTAT5 was determined on paraffin-embedded bm sections by immunohistochemistry using the pSTAT5-specific antibody AX1. In the normal bm, the antibody AX1 was found to react with megakaryocytes and immature myeloid progenitor cells, whereas erythroid cells and mature granulocytic cells did not stain positive for AX1. In patients with AML and CML, the distribution of pSTAT5 showed a similar pattern. In fact, pSTAT5 was found to be expressed in leukemic blast cells without differences among FAB types as well as megakaryocytic cells, but not in erythroid cells. In patients with SM, neoplastic mast cells were found to be immunoreactive for pSTAT5. Interestingly, in all patients and all cells examined, pSTAT5 was found to be localized in the cytoplasm rather than in the nucleus. The cytoplasmic distribution of pSTAT5 in neoplastic cells was confirmed by immunocytochemical staining experiments performed on primary isolated neoplastic cells (AML, CML, mastocytosis) and respective cell lines (U937, KG1, K562, KU812, HMC-1). In each case, the reactivity of neoplastic cells with the AX1 antibody was abrogated by preincubation of the antibody with a pSTAT5-specific blocking peptide. Moreover, the expression of cytoplasmic pSTAT5 in the leukemic cell lines was demonstrable by flow cytometry. To study the molecular mechanisms underlying STAT5-activation in neoplastic cells, Ba/F3 cells with doxycycline-inducible expression of disease-specific oncoproteins, namely BCR/ABL (CML) and KIT-D816V (SM) were employed. Induction of these oncoproteins in Ba/F3 cells resulted in massive activation of pSTAT5 and DNA binding activity as shown by EMSA and supershift assays. In summary, our data show that neoplastic cells in AML, CML, and SM express cytoplasmic pSTAT5, and that disease-related oncoproteins contribute to STAT5-activation. The particular cytoplasmic localization of pSTAT5 in neoplastic cells suggests that apart from its function as a transcription factor, pSTAT5 may have an additional role as a cytoplasmic regulator in these malignancies.
Outcomes After Non-Myeloablative Allogeneic Hematopoietic Cell Transplantation with Total Lymphoid Irradiation and Anti-Thymocyte Globulin in Lymphoid Malignancies After Failed Autologous Transplantation (2013)

Patients with lymphoid malignancies who relapse after autologous hematopoietic cell transplantation (HCT) have few curative treatment options. Allogeneic HCT using full dose conditioning can cure selected patients but high non-relapse mortality (NRM) limits its broad applicability. We developed reduced intensity conditioning for allogeneic HCT with total lymphoid irradiation and rabbit anti-thymocyte globulin (TLI-ATG) that was safe, well tolerated, protected against GVHD and allowed for retained graft-versus tumor reactions. We report the outcomes of 47 consecutive patients with lymphoid malignancies who relapsed after auto-HCT and received TLI-ATG conditioning followed by the infusion of G-mobilized allografts. Included were 29 (62%) patients at high risk of relapse because the disease failed to achieve remission with salvage therapy prior to TLI-ATG, 20 (43%) patients with relapse within 18 months of their auto-HCT, and 22 (47%) patients at high risk of developing GVHD due to the lack of fully HLA-matched related donor. 26 patients had B-cell NHL (diffuse large B-NHL (n=19), mantle cell lymphoma (n=4) or other subtypes (n=3)) all of whom received prior rituximab, 6 patients had T cell NHL, and 15 had Hodgkin lymphoma. The TLI-ATG regimen was well tolerated and 46 (98%) patients received their graft infusion as an outpatient. The hospital readmission rate in the first 100 days was 28% (n=13). Only 13 (28%) and 4 (9%) patients recorded an ANC <0.5x109/L or a platelet count <10x109/L respectively, during the first 30 days post HCT. Durable chimerism was achieved in 45 (96%) patients. The cumulative incidence of grade II-IV acute GVHD at day 100 was 12% and extensive chronic GVHD at 1-yr was 36%. Non-relapse mortality (NRM) at 3 years was 7%. The median follow up for all patients was 1142 days and 1525 days (range; 365-3667) for the 34 (72%) living patients. The 36-month probability of progression free and overall survival (OS) was 40% and 79% respectively. It is noteworthy that among the 23 patients with progressive disease after TLI-ATG, 11 were returned to durable (>1 year) complete remission without subsequent relapse following a donor lymphocyte infusion or chemo-radiotherapy. 13 patients died (relapse=8 and other causes=5). Proportional hazards model showed improved relapse free survival with higher CD3+ donor chimerism (p=0.01). We conclude that for patients with lymphoma relapse after auto-HCT, allogeneic HCT from a sibling or unrelated donor using TLI-ATG conditioning was a well tolerated outpatient procedure, did not induce significant cytopenias and was associated with 3 year NRM of <10%. It is unlikely that TLI-ATG conditioning itself provided long-term lymphoma control in these heavily pre-treated patients, with advanced disease. Rather the 79% 3-yr OS and the fact that the majority of patients continue in durable CR suggest retained graft antitumor reactions following TLI-ATG.
In vitro and in vivo kinetics of regulated drug release from polymer matrices by oscillating magnetic fields (1987)

The kinetics of drug release from polymer-drug matrices containing an embedded magnet was continuously monitored in vitro and in vivo. The application of an oscillating magnetic field increased the rate of drug release from the polymer matrices. Within the limits of detection the increase in release occurred immediately, remained stable for as long as the field was applied, and returned exactly to baseline upon withdrawal of the field. The increase in release was directly proportional to field amplitude. The same pattern of results were observed in vivo as in vitro, though higher strength fields were required in vivo to achieve the same effect observed in vitro.
Finite element Compton tomography (2007)

In this paper a new approach to 3D Compton imaging is presented, based on a kind of finite element (FE) analysis. A
window for X-ray incoherent scattering (or Compton scattering) attenuation coefficients is identified for breast cancer
diagnosis, for hard X-ray photon energy of 100-300 keV. The point-by-point power/energy budget is computed, based on a
2D array of X-ray pencil beams, scanned vertically. The acceptable medical doses are also computed. The proposed finite
element tomography (FET) can be an alternative to X-ray mammography, tomography, and tomosynthesis. In experiments,
100 keV (on average) X-ray photons are applied, and a new type of pencil beam collimation, based on a Lobster-Eye Lens
(LEL), is proposed.
Two size-selective mechanisms specifically trap bacteria-sized food particles in Caenorhabditis elegans (2009)

Caenorhabditis elegans is a filter feeder: it draws bacteria suspended in liquid into its pharynx, traps the bacteria, and ejects the liquid. How pharyngeal pumping simultaneously transports and filters food particles has been poorly understood. Here, we use high-speed video microscopy to define the detailed workings of pharyngeal mechanics. The buccal cavity and metastomal flaps regulate the flow of dense bacterial suspensions and exclude excessively large particles from entering the pharynx. A complex sequence of contractions and relaxations transports food particles in two successive trap stages before passage into the terminal bulb and intestine. Filtering occurs at each trap as bacteria are concentrated in the central lumen while fluids are expelled radially through three apical channels. Experiments with microspheres show that the C. elegans pharynx, in combination with the buccal cavity, is tuned to specifically catch and transport particles of a size range corresponding to most soil bacteria.