gebhart/patrepeval huggingface dataset:
Conversion and Composition Profiles in Polyurethane Reaction Molding (1979)

Fabrication of most articles from polymeric materials has been done by melt forming of thermoplastic materials. Recently, technology has been developed for rapid insitu polymerization, to form the desired articles directly from monomeric liquids. This process has come to be known as Reaction Injection Molding (RIM).(1) To date, the major commercial RIM-processed materials are polyurethanes. The reasons for this are that polyurethane chemistry is able to provide both 1) fast, complete reaction with no side products, necessary to minimize mold cycle time and 2) a wide degree of modulus variability, through the domainforming properties of segmented polyurethanes and the introduction of some crosslinking, necessary to give the desired mechanical properties. Development of similar desirable characteristics in epoxy, silicone, polyester, nylon (and perhaps other) polymerizations is currently a very active field (2).Principal application of this technology has been in the automotive industry. For example, polyurethane automotive facia as large as
Preferential induction of cross-group influenza A hemagglutinin stem–specific memory B cells after H7N9 immunization in humans (2017)

Antigenic drift and shift of influenza strains underscore the need for broadly protective influenza vaccines. One strategy is to design immunogens that elicit B cell responses against conserved epitopes on the hemagglutinin (HA) stem. To better understand the elicitation of HA stem-targeted B cells to group 1 and group 2 influenza subtypes, we compared the memory B cell response to group 2 H7N9 and group 1 H5N1 vaccines in humans. Upon H7N9 vaccination, almost half of the HA stem-specific response recognized the group 1 and group 2 subtypes, whereas the response to H5N1 was largely group 1-specific. Immunoglobulin repertoire analysis of HA-specific B cells indicated that the H7N9 and H5N1 vaccines induced genetically similar cross-group HA stem-binding B cells, albeit at a much higher frequency upon H7N9 vaccination. These data suggest that a group 2-based stem immunogen could prove more effective than a group 1 immunogen at eliciting broad cross-group protection in humans.
Potentiation of leptazol seizures by 6-hydroxydopamine (1973)

Journal Article Potentiation of leptazol seizures by 6-hydroxydopamine Get access M E Corcoran, M E Corcoran Kinsmen Laboratory of Neurological Research, Department of Psychiatry, The University of British Columbia, Vancouver 8, B.C., Canada Search for other works by this author on: Oxford Academic Google Scholar H C Fibiger, H C Fibiger Kinsmen Laboratory of Neurological Research, Department of Psychiatry, The University of British Columbia, Vancouver 8, B.C., Canada Search for other works by this author on: Oxford Academic Google Scholar E G McGeer, E G McGeer Kinsmen Laboratory of Neurological Research, Department of Psychiatry, The University of British Columbia, Vancouver 8, B.C., Canada Search for other works by this author on: Oxford Academic Google Scholar J A Wada J A Wada Kinsmen Laboratory of Neurological Research, Department of Psychiatry, The University of British Columbia, Vancouver 8, B.C., Canada Search for other works by this author on: Oxford Academic Google Scholar Journal of Pharmacy and Pharmacology, Volume 25, Issue 6, June 1973, Pages 497–499, https://doi.org/10.1111/j.2042-7158.1973.tb09143.x Published: 12 April 2011 Article history Received: 24 January 1973 Published: 12 April 2011
Computer-assisted mechanistic evaluation of organic reactions. 9. Reactions of unsaturated electrophiles including nucleophilic aromatic substitution (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComputer-assisted mechanistic evaluation of organic reactions. 9. Reactions of unsaturated electrophiles including nucleophilic aromatic substitutionCatherine E. Peishoff and William L. JorgensenCite this: J. Org. Chem. 1985, 50, 7, 1056–1068Publication Date (Print):April 1, 1985Publication History Published online1 May 2002Published inissue 1 April 1985https://pubs.acs.org/doi/10.1021/jo00207a030https://doi.org/10.1021/jo00207a030research-articleACS PublicationsRequest reuse permissionsArticle Views274Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
LDP Multipoint Opaque Value Element Types (2009)

[MLDP] describes extensions to the Label Distribution Protocol (LDP)
for setup of point to multi-point (P2MP) and multipoint-to-multipoint
(MP2MP) Label Switched Paths (LSPs). LDP forwarding equivalence class
(FEC) elements used to establish P2MP and MP2MP LSPs include type-
length-value (TLV) fields that carry information meaningful to Ingress
LSRs and Leaf LSRs and are termed as Opaque Value Elements in [MLDP].
This document defines Opaque Value Element structure to be used for
provisioning P2MP and MP2MP Provider tunnels (P-Tunnels) for Multicast
Virtual Private Network (MVPN). It is envisioned that this would be
useful for security and manageability of P-Tunnels used for MVPN from
the ones provisioned for other applications and vice-versa.
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19 (2022)

The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 dataset is one of the largest international databases of prospectively collected clinical data on people hospitalized with COVID-19. This dataset was compiled during the COVID-19 pandemic by a network of hospitals that collect data using the ISARIC-World Health Organization Clinical Characterization Protocol and data tools. The database includes data from more than 705,000 patients, collected in more than 60 countries and 1,500 centres worldwide. Patient data are available from acute hospital admissions with COVID-19 and outpatient follow-ups. The data include signs and symptoms, pre-existing comorbidities, vital signs, chronic and acute treatments, complications, dates of hospitalization and discharge, mortality, viral strains, vaccination status, and other data. Here, we present the dataset characteristics, explain its architecture and how to gain access, and provide tools to facilitate its use.
Enhancing thin dielectric remaining detection under polysilico plug of advanced DRAM by electron beam inspection (2007)

We've studied using negative mode e-beam inspection (EBI) to detect a thin layer of dielectric remain at the bottom of storage node contact (SNC) hole. A thin layer (~15 nm) of nitride at the bottom of some SNC holes was intentionally created, EBI were performed at two stages: post etch clean and after silicon nitride cap of SNC plug. Negative mode EBI after SNC nitride cap deposition successfully captured these contact open defects as bright voltage contrast (BVC) defects. The cross-section scanning electron microscope (SEM) confirmed the results. The inspection mechanism is also discussed in the paper. We found that negative mode EBI is very useful for in-line defect monitoring.
Increased inflammation delays wound healing in mice deficient in collagenase‐2 (MMP‐8) (2007)

Matrix metalloproteinases (MMPs) have been implicated in numerous tissue-remodeling processes. The finding that mice deficient in collagenase-2 (MMP-8) are more susceptible to develop skin cancer, prompted us to investigate the role of this protease in cutaneous wound healing. We have observed a significant delay in wound closure in MMP8-/- mice and an altered inflammatory response in their wounds, with a delay of neutrophil infiltration during the first days and a persistent inflammation at later time points. These changes were accompanied by alterations in the TGF-beta1 signaling pathway and by an apoptosis defect in MMP8-/- mice. The delay in wound healing observed in MMP8-/- mice was rescued by bone marrow transplantation from wild-type mice. Analysis of other MMPs showed that MMP8-/- mice had a significant increase in the expression of MMP-9, suggesting that both proteases might act coordinately in this process. This possibility was further supported by the novel finding that MMP-8 and MMP-9 form specific complexes in vivo. Taken together, these data indicate that MMP-8 participates in wound repair by contributing to the resolution of inflammation and open the possibility to develop new strategies for treating wound healing defects.
ELECTROMODULATION OF PHOTOLUMINESCENCE FROM CdSe NANORODS FILM (2007)

We studied photoluminescence (PL) properties of CdSe nanorods integrated in a thin film sandwiched between transparent electrodes to which an electric field applied. Nearly 20 % of PL quenching accompanied with the weak Stark shift have been observed. This effect is proposed to be used for PL modulation, in particular in the wavelength range beyond the range that traditional optoelectronic devices may cover.
Heat Capacity and Anisotropic Thermal Conductivity in Cr2AlC Single Crystals at High Temperature (2020)

The temperature dependences of both heat capacity and thermal conductivity in nanolamellar Cr2AlC single crystals are measured using modulated photothermal radiometry and compared to first-principles calculations. The electronic contribution to the thermal conductivity of Cr2AlC single crystals is computed ab initio by determining the electronic transport coefficients using density functional theory and by solving the Bloch–Boltzmann transport equation with a temperature-dependent relaxation time. The lattice thermal conductivity is predicted by going beyond the quasi-harmonic approximation and considering renormalized second- and third-order force constant matrices, with anharmonic three-phonon scattering, isotopic scattering, and scattering by carbon vacancies. Isotopic scattering does not modify the lattice thermal conductivity. In contrast, even a small concentration of carbon vacancies induces a substantial decrease of the in-plane lattice thermal conductivity. The anisotropy measured in the thermal conductivity, with a ratio of ∼2 over the whole temperature range, is confirmed theoretically. This anisotropy seems to mainly arise from lattice contributions. A similar anisotropy is expected for other MAX phases with identical layered structures.
Conventional Quantum Chemical Correlation Energy Versus Density-Functional Correlation Energy (1996)

We examine the difference between the correlation energy as defined within the conventional quantum chemistry framework and its namesake in density-functional theory. Both correlation energies are rigorously defined concepts and satisfy the inequality EQCc ≥ EDFTc. We give numerical and analytical arguments suggesting that the numerical difference between the two rigorous quantities is small. Finally, approximate density functional correlation energies resulting from some popular correlation energy functionals are compared with the conventional quantum chemistry values.
DETERMINATION OF PUNGENCY DUE TO CAPSICUM BY GAS‐LIQUID CHROMATOGRAPHY (1977)

ABSTRACT A method is described for determining the pungency, due to capsaicinoids, in raw spices, extracts, food and pharmaceutical products by means of GLC. Pure samples of the individual capsaicinoids were prepared and their pungencies determined by ASTA method 21.0 (Scoville Heat Test). The threshold pungency values for these materials are presented. The pure capsaicinoids were used to quantitate the GLC method and identify capsaicinoids found in natural materials. Details concerning sample preparation and silylation are discussed for various types of samples. By combining the concentration and threshold pungency of the individual capsaicinoids, the Scoville pungency of the material can be determined. Comparative data for pungency determined organolyptically and by GLC on samples ranging from 50,000–2,000,000 Scoville gave a correlation coefficient of 0.95 for raw data over a 1‐yr period.
Oxidation protective carbon layer for magnetic particles by surfactant reduction (1996)

Encapsulation of fine metal particles by graphite would not only provide an oxidation protective layer but also acts as a solid lubricant that enables high speed scanning of magnetic tapes against a writing/recording head. In this paper, we propose a novel method to produce the graphite layer on the surface of magnetic particles. First, the surfactant is adsorbed onto the particle and then reduced/decomposed by bombardment with ionized He atoms in the arc discharge chamber. As a result of this treatment, the magnetite particles are uniformly coated with a graphite layer of a few nanometers thick.
Lipreading by neural networks: Visual preprocessing, learning, and sensory integration (1993)

We have developed visual preprocessing algorithms for extracting phonologically relevant features from the grayscale video image of a speaker, to provide speaker-independent inputs for an automatic lipreading (speechreading) system. Visual features such as mouth open/closed, tongue visible/not-visible, teeth visible/notvisible, and several shape descriptors of the mouth and its motion are all rapidly computable in a manner quite insensitive to lighting conditions. We formed a hybrid speechreading system consisting of two time delay neural networks (video and acoustic) and integrated their responses by means of independent opinion pooling - the Bayesian optimal method given conditional independence, which seems to hold for our data. This hybrid system had an error rate 25% lower than that of the acoustic subsystem alone on a five-utterance speaker-independent task, indicating that video can be used to improve speech recognition.
Enhancement-mode single-layer CVD MoS2 FET technology for digital electronics (2015)

2D nanoelectronics based on single-layer (SL) MoS <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> offers great advantages for ubiquitous electronics. With new device technology, highly uniform E-mode FETs using SL CVD MoS <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> with positive VT, large mobility, excellent subthreshold swing are achieved. The integrated inverter shows excellent voltage transfer characteristic, close to rail-to-rail operation, high noise margin, large voltage gain (~45) and small static power. The combinational and sequential digital circuits shown here serve as a toolbox of building blocks for realizing wide range of digital circuitry.
Handover friendly TCP proxy integrated in the LTE eNodeB (2014)

Serving online applications and commercial web sites with low latency is business critical. As content requests originate from geographically distant locations and increasingly from mobile devices, globally ensuring service quality is challenging. The content is delivered to the clients predominantly via the Transmission Control Protocol (TCP), therefore optimal TCP operation over radio access is highly relevant. The split connection TCP Proxy is an optimization mechanism by itself and also a basic component of solutions such as transparent caching aiming at improved interactivity and reduced access latency. In Long Term Evolution (LTE) systems, the Evolved Node B (eNB) is the best location for the TCP Proxy. However, the eNB side TCP Proxy may inherently cause the collapse of TCP connections after handover, a problem this paper is first to analyze. Due to how user plane connectivity is switched over during LTE handovers, the TCP Proxy uniquely creates the possibility for losing data that cannot be recovered through TCP retransmissions. As a solution, the paper presents a TCP Proxy integrated with the eNB Packet Data Convergence Protocol (PDCP) layer. Simulation results indicate that the PDCP integration complemented with X2 prioritization efficiently prevents unrecoverable losses and enables to safely leverage the benefits of an eNB side TCP Proxy.
Temperature-sensitive mutants of p53 associated with human carcinoma of the lung. (1992)

We have compared the effects of specific point mutations on the tertiary and quaternary structure of the human p53 protein. Eight mutants, each derived from primary resected tissues of lung carcinomas, were expressed in vitro under strictly defined conditions, such that the only known variant was the point mutation present in each p53 mRNA. All the mutations were located in highly conserved domains. The tertiary structure of each mutant protein was investigated by reactivity with anti-p53 monoclonal antibodies directed against conformation-dependent epitopes. Quaternary structure was examined by gel filtration. Although all the mutant proteins exhibited abnormal tertiary structures, their quaternary structures appeared similar to wild type, the one exception being p53-tyr135, which contains tyrosine in place of cysteine at residue 135. The conformational phenotype of mutant human p53 was found to be dependent upon (i) the locus of the mutation and (ii) the nature of the amino acid substitution: two different substitutions at residue 273 yielded two mutants with differing structural properties. We have discovered three mutants of human p53 that are temperature sensitive for conformation; one is mutated at codon 273, a 'hotspot' for p53 mutation in human cancer.
The selective ethanol Guerbet condensation over alkali metal-doped sepiolite (2023)

In this study, alkali metal-doped sepiolite based catalysts were developed for the up-grading of ethanol through the Guerbet reaction mechanism. The catalysts were prepared by wetness impregnation with aqueous solution containing alkali metal precursors salts over calcined sepiolite, and finally activated at 500ºC in air. The catalysts have been characterized by XRD, SEM-EDS, TGA-DSC, N2-adsorption. In addition, TPD-CO2 and TPD-NH3 were used to determine the acid and basic characteristics of catalysts. The catalysts were tested into a quartz continuous gas-flow reaction system working at atmospheric pressure to investigate the effects of metal loading (wt%), the nature of the alkali metals and of the main reaction parameters (e.g., reaction temperature, weight hourly space velocity), on the production of n-butanol starting from ethanol. The highest yield (18%) was obtained at 400 ºC with the catalyst consisting in sepiolite, calcined at 500ºC, impregnated with 7 wt% of Cs. This study proves that ad hoc modified natural sepiolites with alkali metals are effective catalysts for the Guerbet upgrading of ethanol.
High-level Synthesis based upon Dependence Graph for Muli-FPGA (2003)

International audience
A SWRL Bridge to XACML for Clouds Privacy Compliant Policies (2014)

The management of privacy and personal information within multi-cultural domain such as clouds and other universal collaborative systems requires intrinsic compliance-checking and assurance modules in order to increase social trust and acceptance. Focusing mainly on medical domains, this issue is particularly important due to the sensitivity of health related data in international data protection law. The use of ontologies and semantic technologies can provide relatively easy interpretation of legislation at run time, and can allow the logging of data access events to serve for future audits. However, the enforcement of semantic web rules (SWRL rules) on complex and heterogeneous architectures is expensive and might present runtime overheads. We believe a mapping of our semantic web privacy policies to a standard access control language such as XACML would be a useful alternative. A translation to XACML, would allow the integration of these policies with existing security and privacy policies being adopted on clouds environments. This paper describes a mathematical formalism for mapping SWRL (Semantic Web Rule Language) privacy rules to XACML policies and also explains the underline implementation requirements of this formalism.
A DL-4- and TNFα-based culture system to generate high numbers of nonmodified or genetically modified immunotherapeutic human T-lymphoid progenitors (2021)

Several obstacles to the production, expansion and genetic modification of immunotherapeutic T cells in vitro have restricted the widespread use of T-cell immunotherapy. In the context of HSCT, delayed naïve T-cell recovery contributes to poor outcomes. A novel approach to overcome the major limitations of both T-cell immunotherapy and HSCT would be to transplant human T-lymphoid progenitors (HTLPs), allowing reconstitution of a fully functional naïve T-cell pool in the patient thymus. However, it is challenging to produce HTLPs in the high numbers required to meet clinical needs. Here, we found that adding tumor necrosis factor alpha (TNFα) to a DL-4-based culture system led to the generation of a large number of nonmodified or genetically modified HTLPs possessing highly efficient in vitro and in vivo T-cell potential from either CB HSPCs or mPB HSPCs through accelerated T-cell differentiation and enhanced HTLP cell cycling and survival. This study provides a clinically suitable cell culture platform to generate high numbers of clinically potent nonmodified or genetically modified HTLPs for accelerating immune recovery after HSCT and for T-cell-based immunotherapy (including CAR T-cell therapy).
Dragline, Egg Stalk and Byssus: A Comparison of Outstanding Protein Fibers and Their Potential for Developing New Materials (2013)

Abstract This feature article discusses three remarkable protein fibers: spider dragline, lacewing egg stalk and mussel byssus. Sequence–structure–function relationships of selected proteins in the fibers are highlighted and the potential of these proteins for use as new materials is summarized.
Proteomic Investigation of Male Gammarus fossarum, a Freshwater Crustacean, in Response to Endocrine Disruptors (2014)

While the decrease in human sperm count in response to pollutants is a worldwide concern, little attention is being devoted to its causes and occurrence in the biodiversity of the animal kingdom. Arthropoda is the most species-rich phyla, inhabiting all aquatic and terrestrial ecosystems. During evolution, key molecular players of the arthropod endocrine system have diverged from the vertebrate counterparts. Consequently, arthropods may have different sensitivities toward endocrine disrupting chemicals (EDCs). Here alteration of sperm quality in a crustacean, Gammarus fossarum, a popular organism in freshwater risk assessment, was investigated after laboratory exposure to various concentrations of three different xenobiotics: cadmium, methoxyfenozide, and pyriproxyfen. The integrity of the reproductive process was assessed by means of sperm-quality markers. For each substance, semiquantitative/relative proteomics based on spectral counting procedure was carried out on male gonads to observe the biological impact. The changes in a total of 871 proteins were monitored in response to toxic pressure. A drastic effect was observed on spermatozoon production, with a dose-response relationship. While exposure to EDCs leads to strong modulations of male-specific proteins in testis, no induction of female-specific proteins was noted. Also, a significant portion of orphans proved to be sensitive to toxic stress.
Top Picks from the 2016 Computer Architecture Conferences (2017)

The guest editors introduce the Top Picks and Honorable Mentions from the 2016 computer architecture conferences.