gebhart/patrepeval huggingface dataset:
Abstract P2-06-03: Specific Transcriptional Response of Four Blockers of Estrogen Receptors on Estrogen-Modulated Genes in ZR-75-1 Breast Cancer Xenografts (2012)

Abstract Introduction: Acolbifene (ACOL) is a novel compound completely free of estrogen-like activity in both the human and rat mammary gland and uterus. In previous studies, it was observed that ACOL could have a cytotoxic or tumoricidal rather only tumorostatic activity, with a lack of development of tumor resistance. The objective of the present study was to obtain information on the molecular basis of the tumoricidal properties of acolbifene, as well as on the identity of the genes potentially implicated in the resistance to tamoxifen (TAM). The specificity of action of ACOL was compared to the pure antiestrogen fulvestrant (FUL) as well as to tamoxifen (TAM) and raloxifene (RAL). Methods: The gene expression profile of the ZR-75-1 breast cancer xenografts was studied following treatment with ACOL, RAL, TAM and FUL. Ovariectomized female nude mice (10/group) bearing human ZR-75-1 breast cancer xenografts were supplemented with estrone (E1) (subcutaneous silastic implants) and were injected daily with the vehicle alone or 50 μg of ACOL, RAL, TAM or FUL for 6 months. Mice were killed 24h after the last injection and ZR-75-1 tumors were collected and processed for RNA extraction and microarray analyses (Affymetrix GeneChip U133 Plus 2.0). Results: Long-term exposure of ZR-75-1 xenografts to E1 causes a massive modulation of E1-responsive genes. When the antiestrogens were administered simultaneously with E1, some compound-specific prevention of the effect of E1 was observed. Globally, the efficacy of the compounds was ACOL&amp;gt;FUL or RAL&amp;gt;TAM. ACOL significantly prevented the effect of E1 on 195 responsive genes. Among these, the most enriched gene ontological group in Molecular Function was Receptor Activity, including ER, insulin, retinoid and thrombospondin receptor activity. One of the transcriptional repressors of the estrogen signaling pathway, the NKX31, was down-regulated by E1 and completely blocked by ACOL (fold-change −1.64 and 2.54, respectively). The most enriched biological processes were associated with mammary gland development, positive regulation of glucose metabolic processes and blood vessel morphogenesis. Between the genes implicated in cell death/apoptosis of breast cancer cells, the changes of expression of 57, 51, 48 and 31 genes were significantly neutralized by ACOL, RAL, FUL and TAM, respectively. Sixteen genes implicated in tumor resistance to TAM were significantly blocked by ACOL, including DEGS1, a gene implicated in the inhibition of EGF receptor biosynthesis. The other 15 genes in the group were up-regulated by E1, changes which were significantly blocked by ACOL. Conclusion: The present data offer a possible explanation for the potent tumoricidal action of acolbifene in human breast cancer xenografts, thus offering a new paradigm in the hormonal therapy of breast cancer. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P2-06-03.
Scanning Calorimetric Detections of Multiple DNA Biomarkers Contained in Complex Fluids (2010)

Most of the existing techniques cannot be used to detect molecular biomarkers contained in complex fluids due to issues such as enzyme inhibition or signal interference. We have developed a nanoparticle-based scanning calorimetric method for the highly sensitive detections of multiple DNA biomarkers contained in cell lysate and milk by using solid-liquid phase change nanoparticles as thermal barcodes. The detection is based on the principle that the temperature of solid will not rise above the melting temperature unless all solid is molten, thus nanoparticles have sharp melting peaks during the thermal scan process. A one-to-one correspondence can thus be created between one type of nanoparticles and one type of biomarker, i.e., multiple biomarkers can be detected at the same time using a combination of nanoparticles. The melting temperature and the heat flow reflect the type and the concentration of the biomarker, respectively. The target oligonucleotides at low concentration in cell lysate (80 pM) have been detected through thermal signal transduction. The melting temperature of nanoparticles can be designed to avoid interference from coexisting species contained in the fluids, bringing simultaneously high sensitivity and multiplicity, as well as sample preparation benefits to biomarker detections.
An Automatic Clustering Algorithm for Multipath Components Based on Kernel-Power-Density (2017)

In the real-world environments, multipath components (MPCs) of wireless channels are generally distributed as groups, i.e., clusters. Modeling the clustered MPCs is important and necessary for channel modeling and an automatic clustering algorithm is thus required. This paper proposes a novel Kernel-power-density (KPD) based algorithm for MPC clustering. It uses the Kernel density to incorporate the modeled behavior of MPCs and takes into account the power of the MPCs. The proposed algorithm only considers the K nearest MPCs in the density estimation to better identify the local density variations of MPCs. Simulations validate the KPD algorithm and almost no performance degradation is found even with a large number of clusters and large cluster angular spread. The KPD algorithm enables applications with no prior knowledge about the clusters such as number and initial locations. It can be used for the cluster based channel modeling for 4G#x002F;5G communications.
<title>Measured Terfenol-D material properties under varied applied magnetic field levels</title> (1996)

An experimental approach is used to identify Terfenol-D material properties under magnetic bias and mechanical prestress conditions typical of transducer applications for the magnetostrictive material Terfenol-D. The approach is based on low signal transduction models, a mechanical model of the test transducer, and on the theory of vector impedance and admittance analysis. The material properties being investigated, measured directly or calculated from measured quantities, are: two Young's moduli, magnetomechanical coupling factor (or 'figure of merit' of the material), linear coupling coefficient or axial strain coefficient (d<SUB>33</SUB>) and two magnetic permeabilities. Electrical impedance and admittance and acceleration per unit current complex functions are measured at frequencies from 100 Hz to 5 kHz using a swept sine excitation at five applied magnetic field levels. Ten Terfenol-D samples are used in randomized performance tests to obtain the preliminary material property information that is presented. Of these ten rods, two were used in randomized performance repeatability tests for which data is also presented. These data sets demonstrate the dependence of material properties on applied magnetic field levels, and provide a preliminary assessment of the variability in material properties given known operating conditions.
CO2 measurement for the early differential diagnosis of pulmonary embolism-related shock at the emergency department: A case series (2015)

An initial CO2 measurement might be an easily available tool for the early diagnostic work-up of clinical shock.
TSL and OSL Properties of Cu-doped CaF2 Ceramics Prepared by Spark Plasma Sintering (2022)

The thermally and optically stimulated luminescence (TSL and OSL) properties of Cu-doped CaF 2 ceramics synthesized by spark plasma sintering (SPS), as well as their scintillation and photoluminescence (PL) properties, were investigated. The PL and scintillation spectra showed emission peaks at 390 and 490 nm, which were ascribed to Cu + ions and Cu clusters, respectively, judging from the PL decay time constants. After X-ray irradiation, TSL and OSL were observed upon heating at 182 C and irradiating light of 620 nm, respectively. The dominant luminescence centers in the TSL and OSL processes were considered to be Cu clusters. The 0.1% Cu-doped CaF 2 sample had a linear TSL response in the dose range from 0.01 to 1000 mGy.
Rastreamento eficiente de faces em um subespaço wavelet (2001)

\n O reconhecimento computacional de faces humanas a partir de seqüências de vídeo emerge nos dias atuais como um instigante e desafiador campo de pesquisa. Os resultados dos estudos realizados neste tema encontram diversas aplicações em sistemas de segurança, autenticação de usuários, interação homem-máquina e outras. Em geral, três etapas são discriminadas em um sistema de reconhecimento de faces a partir de vídeo: (1) detecção e rastreamento da face do usuário, (2) segmentação e normalização da face em cada quadro da seqüência, e (3) extração de características e classificação. O objetivo do presente trabalho consiste no estudo e desenvolvimento de algoritmos de visão computacional relativos à primeira etapa, com ênfase no problema de rastreamento de faces. A detecção da presença da face do usuáqrio, em uma sequencia de imagens, foi realizada utilizando-se um procedimento baseado em um modelo estatístico de cor da pele. Em contrapartida, para efetuar o rastreamento da face, realizamos experimentos com a técnica mais sofisticada, recentemente proposta na literatura, denominada Gabor wavelet networks (GWNs). O problema de localização e rastreamento de características faciais também foi tratado, visto que o módulo de reconhecimento, atualmente sendo implementado por outro aluno de mestrado [Campos, 2001], utiliza essas características para efetuar a classificação da face. Como principal contribuição deste estudo, salientamos a proposição de um método eficiente de rastreamento de faces, realizado em um subespaço wavelet de baixa dimensionalidade. Mais especificamente, esse método constitui um aperfeiçoamento, em termos de eficiência, da técnica de rastreamento baseada em GWNs. A comparação de ambas abordagens, bem como a avaliação de pperformance da técnica introduzida, considerando aspectos como precisão, robutez e eficiência, serão discutidas ao longo deste trabalho\n
Modifications of cell wall properties by production of recombinant resilin composites in transgenic plants (2013)

Resilin is a polymeric rubber-like protein, secreted by insects to specialized cuticle regions. Its unique mechanical properties allow, among others, the outstanding jumping ability of fleas, up to 30 cm high. The elastic properties of resilin are achieved by formation of di-tyrosine bridges within resilin monomers and cuticle polysaccharides, generated by peroxidase enzymes, in the insect cuticles. This highly resilience and elastic protein was optimized for expression in tobacco and was directed to the cell wall by a signal peptide. Cross-linking of resilin to the cell wall polysaccharides was enabled by utilizing the presence of natural plant cell wall peroxidases. Resilin was located in the cell wall by immunohistochemistry. Increase in typical di-tyrosine blue florescence of the cell wall, indicates resilin polymerization and cross-linking. The integration of resilin to the cell wall changed the mechanical properties of the plant tissue. Transgenic stems showed reduction in young’s modulus and an increase in the ability to strain before failure. Moreover, changes in the formation of the plant cell wall, due to the cross-linking of resilin, improved sugars release from plant material. Tobacco is a model plant in this research. Transformation of resilin to eucalyptus trees is currently in progress. Such transgenic trees can be wind resilient and used in the future for production of elastic wood and fibers from transgenic forest, for the paper and wood products industry and for replacement of synthetic materials, with biodegradable ones. Itan Preis et al., Adv Genet Eng 2013, 2:3 http://dx.doi.org/10.4172/2169-0111.S1.002
Interface Effects in Type-II CdSe/BeTe Quantum Dots (2002)

We report on optical and structural studies of the interface symmetry in CdSe/BeTe multiple-layer structures containing self-assembled quantum dots. Temperature and decay behavior of the broad photoluminescence (PL) band is consistent with the type-II transitions involving deeply localized electron states. Large linear in-plane polarization of the PL (up to 80%) is observed, implying the C2v (or lower) symmetry of the individual places of the electron localization.
Extracellular vesicles as biomarkers and therapeutic targets for cancer (2019)

Extracellular vesicles (EVs) are small lipid membrane vesicles that are secreted from almost all kinds of cells into the extracellular space. EVs are widely accepted to be involved in various cellular processes; in particular, EVs derived from cancer cells have been reported to play important roles in modifying the tumor microenvironment and promoting tumor progression. In addition, EVs derived from cancer cells encapsulate various kinds of tumor-specific molecules, such as proteins and RNAs, which contribute to cancer malignancy. Therefore, the unveiling of the precise mechanism of intercellular communication via EVs in cancer patients will provide a novel strategy for cancer treatment. Furthermore, a focus on the contents of EVs could promote the use of EVs in body fluids as clinically useful diagnostic and prognostic biomarkers. In this review, we summarize the current research knowledge on EVs as biomarkers and therapeutic targets and discuss their potential clinical applications.
Single dose topical inserts containing tenofovir alafenamide fumarate and elvitegravir provide pre- and post-exposure protection against vaginal SHIV infection in macaques (2022)

Funded by CDC intramural funds, an interagency agreement between CDC and USAID (USAID/CDC IAA AID-GH-T-15-00002), and by the U.S. President's Emergency Plan for AIDS Relief (PEPFAR) through the U.S. Agency for International Development (USAID) under a Cooperative Agreement (AID-OAA-A-14-00010) with CONRAD/Eastern Virginia Medical School.
Foxo3-/- mice demonstrate reduced numbers of pre-B and recirculating B cells but normal splenic B cell sub-population distribution (2009)

B cell antigen receptor (BCR) cross-linking promotes proliferation and survival of mature B cells. Phosphoinositide-3-kinase-mediated down-regulation of pro-apoptotic and anti-mitogenic genes such as the Foxo family of transcription factors is an important component of this process. Previously, we demonstrated that BCR signaling decreases expression of transcripts for Foxo1, Foxo3 and Foxo4. We now show that BCR-induced down-regulation of Foxo3 and Foxo4 mRNA expression occurs via distinct mechanisms from those established for Foxo1. While Foxo1, Foxo3 and Foxo4 bind the same DNA sequence, the differential control of their expression upon B cell activation suggests that they may have unique functions in the B lineage. To begin to address this issue, we evaluated B cell development and function in Foxo3-/- mice. No effect of Foxo3 deficiency was observed with respect to the following parameters in the splenic B cell compartment: sub-population distribution, proliferation, in vitro differentiation and expression of the Foxo target genes cyclin G2 and B cell translocation gene 1. However, Foxo3-/- mice demonstrated increased basal levels of IgG2a, IgG3 and IgA. A significant reduction in pre-B cell numbers was also observed in Foxo3-/- bone marrow. Finally, recirculating B cells in the bone marrow and peripheral blood were decreased in Foxo3-/- mice, perhaps due to lower than normal expression of receptor for sphingosine-1 phosphate, which mediates egress from lymphoid organs. Thus, Foxo3 makes a unique contribution to B cell development, B cell localization and control of Ig levels.
Dendrons on Insoluble Supports: Synthesis and Applications (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Optical coherence and theoretical study of the excitation dynamics of a highly symmetric cyclophane-linked oligophenylenevinylene dimer (2006)

Optoelectronic properties of a polyphenylenevinylene-based oligomer and its paracylophane-linked dimer are studied using a variety of experimental and theoretical techniques. Despite the symmetrical structure and redshifted absorption of the dimer versus the monomer, an exciton picture is not the most appropriate. Electronic structure calculations establish changes in charge density upon optical excitation and show localized excitations that cannot be accounted for by a simple Frenkel exciton model. Visible frequency pump-probe anisotropy measurements suggest that the dimer should be considered as a three-level system with a fast, approximately 130 fs, internal conversion from the higher to lower energy excited electronic state. Signatures of nuclear relaxation processes are compared for electric field-resolved transient grating and two-dimensional photon echo spectra. These measurements reveal that nuclear relaxation occurs on similar time scales for the monomer and dimer. The connection between the spectral phase of four-wave mixing signals and the time dependent width of a nuclear wave packet is discussed. Semiempirical electronic structure and metropolis Monte Carlo calculations show that the dominant line broadening mechanisms for the monomer and dimer are associated with inter-ring torsional coordinates. Together, the theoretical calculations and electric field-resolved four-wave mixing experiments suggest that while the structure of dimer is more rigid than that of monomer, the difference in their rigidities is not sufficient to slow down excited state relaxation of dimer with respect to the monomer.
Factors predictive of regret in sex reassignment (1998)

The objective of this study was to evaluate the features and calculate the frequency of sex-reassigned subjects who had applied for reversal to their biological sex, and to compare these with non-regretful subjects. An inception cohort was retrospectively identified consisting of all subjects with gender identity disorder who were approved for sex reassignment in Sweden during the period 1972-1992. The period of time that elapsed between the application and this evaluation ranged from 4 to 24 years. The total cohort consisted of 218 subjects. The results showed that 3.8% of the patients who were sex reassigned during 1972-1992 regretted the measures taken. The cohort was subdivided according to the presence or absence of regret of sex reassignment, and the two groups were compared. The results of logistic regression analysis indicated that two factors predicted regret of sex reassignment, namely lack of support from the patient's family, and the patient belonging to the non-core group of transsexuals. In conclusion, the results show that the outcome of sex reassignment has improved over the years. However, the identified risk factors indicate the need for substantial efforts to support the families and close friends of candidates for sex reassignment.
Monolithically integrated 1/spl times/32 optical splitter/router low loss ripple MZI-based WDM filter and low loss Y-branch circuit (2006)

We demonstrated a novel monolithically integrated 1times32 optical splitter/router with functions as an optical splitter for 1.31 mum-band, 1.49 mum-band and as a wavelength router for 1.55 mum-band using a low loss ripple MZI-based WDM filter and a low loss Y-branch circuit
Expression of wild‐type and mutant S20G hIAPP in physiologic knock‐in mouse models fails to induce islet amyloid formation, but induces mild glucose intolerance (2011)

Physiologic expression of hIAPP(WT) and hIAPP(S20G) in C57Bl/6 mice produces mild glucose intolerance with inappropriately normal insulin secretion that is independent of intraislet amyloid formation. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2011.00166.x, 2011).
Reliability of a Novel Classification System for Thoracolumbar Injuries: The Thoracolumbar Injury Severity Score (2006)

The TLISS has good reliability and compares favorably to other contemporary thoracolumbar fracture classification systems.
Numerical analysis of the Raman spectrum evolution and soliton pulse generation in single-mode fibers (1991)

Numerical simulation is used to investigate the evolution of Raman spectra in the negative group-velocity dispersion regime of fibers for continuous-wave pump radiation. It is shown that the ratio of the pump power to the power of the fundamental soliton with a duration of approximately the inverse of the Raman gain linewidth is of great importance. Depending on its value, either cascade Raman scattering (with successive generation of the discrete Stokes components at relative frequency shifts of ~440 cm−1) or the generation of a Raman continuum is observed. In the time domain such a Raman continuum represents a random sequence of soliton-like pulses. The possibilities of the generation of a single solitonlike pulse from the Raman continuum are analyzed.
Parametric binaural rendering utilizing compact microphone arrays (2015)

The spatial capture patterns according to head-related transfer-functions (HRTFs) can be approximated using linear beamforming techniques. However, assuming a fixed spatial aliasing frequency, with reduction of the number of sensors and thus the array size, the linear approach leads to an excessive amplification of the microphone noise, unless the beam patterns are made broader than determined by the HRTFs. An adaptive technique is proposed that builds upon the assumption that the binaural perception is largely determined by a set of short-time inter-aural parameters in frequency bands. The parameters are estimated from the noisy HRTF beam pattern signals as a function of time and frequency. As a result of temporal averaging, the effect of the noise is mitigated while the perceptual spatial information is preserved. Signals with higher SNR from broader patterns are adaptively processed to obtain the parameters from the estimation stage by means of least-squares optimized mixing and decorrelation. Listening tests confirmed the perceptual benefit of the proposed approach with respect to linear techniques.