gebhart/patrepeval huggingface dataset:
Chemical Modification of Hyaluronic Acid: Alkylation (2010)

Hydrophobically modified derivatives of hyaluronic acid (HA) are characterized by means of differential scaning calorimetry (DSC) measurements. Simultaneously, viscosity and elasticity are monitored by rheological measurements. Alkylation of HA macromolecule brings about a strong change in the rheological properties of the biopolymer, which leads to the succesful micelle formation process. The latter then create a highly organized supramolecular structure in the solution, which at the length of the alkyl chain of C15 and higher, is characterized by the creation of the isotropic liquid crystal phase transition.
Polaron Localization at Interfaces in High‐Mobility Microcrystalline Conjugated Polymers (2009)

The charge-induced optical absorptions of two-dimensional polarons in semicrystalline, high-mobility conjugated polymers are investigated as a function of distance from an interface with polymer gate dielectrics of different dielectric constants. For high-k dielectrics, polarons in the accumulation layer at the interface are found to be more localized than those in the bulk.
Physical Methods for Electrical Trap-and-Kill Fly Traps Using Electrified Insulated Conductors (2022)

In the present study, we analyzed negative electricity released from insects captured by an electric field (EF)-producing apparatus. Adult houseflies (<i>Musca domestica</i>) were used as the model insect. The EF producer consisted of a negatively charged polyvinyl chloride membrane-insulated iron plate (N-PIP) and a non-insulated grounded iron plate (GIP) paralleled with the N-PIP. An EF was formed in the space between the plates. A housefly placed on the GIP was physically attracted to the N-PIP, and electricity released from the fly was detected as a specific transient electric current at the time of attraction and during subsequent confinement of the fly to the N-PIP. The magnitude of the insect-derived electric current became larger as the voltage applied to the N-PIP increased. We determined the total amount of electric current and confinement time within the apparatus necessary to kill all captured flies. These results demonstrate the insecticidal function and insect-capturing ability of the EF-producing apparatus.
Attainment of high sensitivity at elevated operating temperatures with staring hybrid HgCdTe-on-sapphire focal plane arrays (1994)

Cost-effective high-performance IR imaging cameras need affordable staring focal plane arrays (FPAs) that can operate effectively at temperatures compatible with inexpensive long-life coolers. We report on staring hybrid 128 x 128 and 256 x 256 Hg<sub>1-<i>x</i></sub>Cd<sub><i>x</i></sub>Te FPAs that have requisite yield, sensitivity, operability, and reliability at a medium-wavelength IR (MWIR) cutoff wavelength (λ<sub><i>c</i></sub> ~4.6 μm at 180 K) and elevated operating temperatures. Mean 256 x 256 FPA noise-equivalent temperature differences (NEΔT) using broadband <i>f</i>/1.7 optics were 4.3, 7.7, and 55 mK at 120, 140, and 180 K, respectively. We extrapolate that camera NEΔT ≤ 0.02 K can be achieved at 190 K using optimized (λ<sub><i>c</i></sub> of ~4.4 μm (180 K), a 3.4- to 4.2-μm bandpass filter, and <i>f</i>/1 optics. Because the CMOS multiplexers have a low-power dissipation and need little ancillary circuitry in the dewar, a viable thermoelectrically-cooled FPA technology is thus implied once the λ<sub><i>c</i></sub> is optimized for MWIR imaging.
Clinical and Laboratory Parameters of Mast Cell Activation as Basis for the Formulation of Diagnostic Criteria (2011)

Mast cell (MC) activation occurs in a number of different pathologic conditions. Acute activation is commonly seen in patients with allergic reactions, with consecutive massive release of vasoactive and proinflammatory mediator substances from MCs, leading to the clinical signs and symptoms of anaphylaxis. In these patients, serum tryptase concentrations usually increase subtantially above baseline levels. Chronic MC activation is more difficult to diagnose, especially when symptoms are mild or atypical, and no underlying disease is found. In these patients, serum tryptase levels usually are normal. In a smaller group of patients, tryptase levels are constantly elevated and may point to an occult form of mastocytosis. These patients have to be examined for MC monoclonality, other criteria of a primary MC disease, non-MC hematopoietic neoplasms, and reactive disorders producing chronic MC activation or MC accumulation. In most patients in whom MC activation is found, histamine-induced symptoms can be documented and usually respond to treatment with histamine receptor antagonists or MC stabilizers. If this is not the case, alternative explanations for symptoms and differential diagnoses have to be considered.
An empirical path loss model for HVAC duct systems (2004)

We present a simple path loss prediction model for link budget analysis in indoor wireless local area networks (LANs) that use heating, ventilation, and air conditioning (HVAC) ducts. The model we propose predicts the average power at each location in an HVAC duct network. This prediction model greatly simplifies the analysis for a complex duct network, making it a convenient and simple tool for system design. Our prediction model Is verified by experimental measurements.
Software-based Intradyne Detection for Optical High-speed Inter-satellite Links with M-PSK (2016)

We present experimental results for intradyne detection as an alternative for current homodyne systems in optical inter-satellite links. Our approach is based on digital frequency offset and phase noise compensation for more flexible coherent systems.
Server based QoS routing (2003)

We discuss schemes for a centralized implementation of a QoS routing protocol, where a route server is responsible for determining QoS routes on behalf of all the routers in a network. We argue that this centralized organization has some advantages, when compared to a conventional distributed link state implementation. We discuss techniques for efficient maintenance of QoS topology information at the server and for reducing the amount of requests for routes that the network will generate. Using a comprehensive cost model based on measurements taken from a real implementation, we evaluate the feasibility and the cost of server based QoS routing in a variety of network configurations. Our results show that such an implementation is well within the capabilities of off-the-self routing equipment.
Monitoring Disease Progression in CADASIL With Diffusion Magnetic Resonance Imaging (2002)

These results suggest that the measurement of water diffusion over time is a sensitive marker for the progression of tissue damage in the brain. Thus, quantitative diffusion MRI can be used to monitor disease progression in CADASIL and possibly in other types of small-vessel brain disorders.
Parametric response mapping of COPD phenotypes: A COPDGene study (2015)

<b>Background:</b> Chronic obstructive pulmonary disease (COPD) has few effective treatments due to its various phenotypes. Analytical techniques for quantitative CT may provide more accurate diagnoses. <b>Methods:</b> We Evaluated parametric response mapping (PRM) from a subset (n=4832: GOLD 0-4) of over 7,281 smokers with and without COPD accrued for the COPDGene study. PRM classifies lung by thresholding HU values from spatially aligned inspiration/expiration (Ins/Exp) HRCT. PRM<sup>fSAD</sup> and PRM<sup>Emph</sup>, which represent functional small airways disease and emphysema, respectively, were correlated to FEV1pp, 6-min walking distance, St. George Respiratory Questionnaire, BODE and history of severe exacerbation in the prior year. Statistical analysis was performed using linear or logistic modeling controlling for age, BMI, pack years and gender. <b>Results:</b> PRM measures for emphysema and small airways disease were both independently associated with SGRQ, BODE and severe exacerbations. <b>Conclusions:</b> PRM, an imaging biomarker, provides an opportunity to understand the impact of structural abnormality on clinical disease severity in COPD.
Inducible Nitric Oxide Synthase Protection Against Coxsackievirus Pancreatitis (1999)

Coxsackievirus infection causes myocarditis and pancreatitis in humans. In certain strains of mice, Coxsackievirus causes a severe pancreatitis. We explored the role of NO in the host immune response to viral pancreatitis. Coxsackievirus replicates to higher titers in mice lacking NO synthase 2 (NOS2) than in wild-type mice, with particularly high viral titers and viral RNA levels in the pancreas. Mice lacking NOS have a severe, necrotizing pancreatitis, with elevated pancreatic enzymes in the blood and necrotic acinar cells. Lack of NOS2 leads to a rapid increase in the mortality of infected mice. Thus, NOS2 is a critical component in the immune response to Coxsackievirus infection.
Protein–RNA and protein–protein interactions mediate association of human EST1A/SMG6 with telomerase (2007)

The human EST1A/SMG6 polypeptide physically interacts with the chromosome end replication enzyme telomerase. In an attempt to better understand hEST1A function, we have started to dissect the molecular interactions between hEST1A and telomerase. Here, we demonstrate that the interaction between hEST1A and telomerase is mediated by protein-RNA and protein-protein contacts. We identify a domain within hEST1A that binds the telomerase RNA moiety hTR while full-length hEST1A establishes in addition RNase-resistant and hTR-independent protein-protein contacts with the human telomerase reverse transcriptase polypeptide (TERT). Conversely, within hTERT, we identify a hEST1A interaction domain, which comprises hTR-binding activity and RNA-independent hEST1A-binding activity. Purified, recombinant hEST1A binds the telomerase RNA moiety (hTR) with high affinity (apparent overall K(d) = 25 nM) but low specificity. We propose that hEST1A assembles specifically with telomerase in the context of the hTR-hTERT ribonucleoprotein, through the high affinity of hEST1A for hTR and specific protein-protein contacts with hTERT.
Fast and accurate annotation of short texts with Wikipedia pages (2010)

We address the problem of cross-referencing text fragments with Wikipedia pages, in a way that synonymy and polysemy issues are resolved accurately and efficiently. We take inspiration from a recent flow of work [Cucerzan 2007, Mihalcea and Csomai 2007, Milne and Witten 2008, Chakrabarti et al 2009], and extend their scenario from the annotation of long documents to the annotation of short texts, such as snippets of search-engine results, tweets, news, blogs, etc.. These short and poorly composed texts pose new challenges in terms of efficiency and effectiveness of the annotation process, that we address by designing and engineering TAGME, the first system that performs an accurate and on-the-fly annotation of these short textual fragments. A large set of experiments shows that TAGME outperforms state-of-the-art algorithms when they are adapted to work on short texts and it results fast and competitive on long texts.
Identification and quantification of lignin monomers and oligomers from reductive catalytic fractionation of pine wood with GC × GC – FID/MS (2021)

Comprehensive HT-GC × GC FID/MS enables reliable detection and quantification of RCF lignin monomers, dimers and, trimers.
Analysis and Characterization of Mycoplasma gallisepticum Isolates from Pennsylvania (1994)

Because Mycoplasma gallisepticum F strain vaccine can be pathogenic in chickens and is pathogenic in turkeys, we monitored the spread of MG F strain into unvaccinated flocks by screening field and experimental isolates. Thirteen MG isolates obtained from various sources in Pennsylvania were screened using several techniques capable of differentiating between MG strains. DNA restriction enzyme analysis (REA), Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) protein profiles, non-isotopic DNA probes, and a monoclonal antibody specific for F strain were used to characterize each of the 13 isolates. Three of the 13 isolates were identical to F strain; two of these were obtained from challenge studies, and one was a field isolate from a multiple-age commercial egg farm where the F strain vaccine had been used in the past. The remaining 10 isolates were different from MG F strain but were quite similar if not identical to each other according to REA; SDS-PAGE protein profiles show similarities between the 10 isolates. The results suggested that F strain vaccine is not a major cause of field outbreaks of MG in Pennsylvania.
A repetitive microsecond-pulse generator for plasma application (2012)

Pulsed discharge is a promising approach for producing non-thermal plasma at atmospheric pressure. Pulsed power generators vary widely in performance and should be chosen according to the application requirements. In this paper, a repetitive microsecond-pulse generator was constructed using a cascading of power modules, where all solid-state switches were considered as the key units. The generator was able to produce repetitive pulses with a peak voltage of 2 kV, a pulse duration of a few microseconds, and a pulse repetition frequency of 5 kHz at a 1000Ω resistive load. Output pulse voltage could be adjusted by varying ac input voltage. Both the pulse width and frequency could be controlled by changing the driving signal of the IGBT. In addition, this generator was successfully used in the plasma application.
Process-noise adaptive particle filtering with dependent process and measurement noise (2016)

Knowledge of the noise distributions is typically key for reliable state estimation. However, in many applications only the measurement noise can be determined a priori, since only this correspond to measurable quantities. Moreover, modeling of physical systems often leads to nonlinear state-space models with dependent noise sources. Here, we design a computationally-efficient marginalized particle filter for jointly estimating the state trajectory and the parameters of the process noise, assuming dependent noise sources. Our approach relies on marginalization and subsequent update of the sufficient statistics of the process-noise parameters. Results and comparisons for a benchmark example indicate that our method gives clear improvements.
Regulation of RraA, a Protein Inhibitor of RNase E-Mediated RNA Decay (2006)

The recently discovered RraA protein acts as an inhibitor of the essential endoribonuclease RNase E, and we demonstrated that ectopic expression of RraA affects the abundance of more than 700 transcripts in Escherichia coli (K. Lee, X. Zhan, J. Gao, J. Qiu, Y. Feng, R. Meganathan, S. N. Cohen, and G. Georgiou, Cell 114:623-634, 2003). We show that rraA is expressed from its own promoter, P(rraA), located in the menA-rraA intergenic region. Primer extension and lacZ fusion analysis revealed that transcription from P(rraA) is elevated upon entry into stationary phase in a sigma(s)-dependent manner. In addition, the stability of the rraA transcript is dependent on RNase E activity, suggesting the involvement of a feedback circuit in the regulation of the RraA level in E. coli.
POS-534 TRAJECTORIES OF CLINICAL AND LABORATORY CHARACTERISTICS ASSOCIATED WITH COVID-19 IN HEMODIALYSIS PATIENTS BY SURVIVAL (2021)

We evaluated the trajectories of clinical and laboratory assessments associated with COVID-19 in hemodialysis (HD) patients who survived or died within 30 days after suspicion. For comparison, we also evaluated consistent trajectories before suspicion in patients tested for SARS CoV-2 who were found to be COVID-19 negative.
Gravity in Greenland (1988)

Preliminary results of the test of the Newtonian Law of Gravitation conducted by Ander et al., in a borehole in the Greenland ice-cap were reported at this meeting. In this paper we consider the interpretations of these results in terms of a non-Newtonian component of gravity, and compare them with the results of other geophysical inverse-square law tests. 8 refs.
A novel adaptive scheme for channel estimation (2012)

In this work a novel adaptive scheme for channel estimation is presented. A controlling factor in the range [0,1] is used to control a mixture of two norms. The derivation of the algorithm is reported in detail. Also, the excess mean-square error is derived. The simulation results obtained corroborate the theory developed.
Flaw detection on Inconel600® using separation of single and multiple scattering contributions (2012)

International audience
ChemInform Abstract: A Samarium(II) Iodide Promoted Tandem Radical Cyclization. The Total Synthesis of (.+‐.)‐Hypnophilin and the Formal Synthesis of (.+‐.)‐Coriolin. (1988)

Abstract The key step in the synthesis of racemic hypnophilin (VII) is the tandem radical cyclization of the ketal (IV) in the presence of SmI 2 .
On the steady-state and tracking analysis of the complex SRLMS algorithm (2014)

In this paper, the steady-state and tracking behavior of the complex signed regressor least mean square (SRLMS) algorithm are analyzed in stationary and nonstationary environments, respectively. Here, the SRLMS algorithm is analyzed in the presence of complex-valued white and correlated Gaussian input data. Moreover, a comparison between the convergence performance of the complex SRLMS algorithm and the complex least mean square (LMS) algorithm is also presented. Finally, simulation results are presented to support our analytical findings.
Reproducibility and Repeatability of MR Fingerprinting Relaxometry in the Human Brain (2019)

Background Only sparse literature investigates the reproducibility and repeatability of relaxometry methods in MRI. However, statistical data on reproducibility and repeatability of any quantitative method is essential for clinical application. Purpose To evaluate the reproducibility and repeatability of two-dimensional fast imaging with steady-state free precession MR fingerprinting in vivo in human brains. Materials and Methods Two-dimensional section-selective MR fingerprinting based on a steady-state free precession sequence with an external radiofrequency transmit field, or <i>B</i><sub>1</sub><sup>+</sup>, correction was used to generate T1 and T2 maps. This prospective study was conducted between July 2017 and January 2018 with 10 scanners from a single manufacturer, including different models, at four different sites. T1 and T2 relaxation times and their variation across scanners (reproducibility) as well as across repetitions on a scanner (repeatability) were analyzed. The relative deviations of T1 and T2 to the average (95% confidence interval) were calculated for several brain compartments. Results Ten healthy volunteers (mean age ± standard deviation, 28.5 years ± 6.9; eight men, two women) participated in this study. Reproducibility and repeatability of T1 and T2 measures in the human brain varied across brain compartments (1.8%-20.9%) and were higher in solid tissues than in the cerebrospinal fluid. T1 measures in solid tissue brain compartments were more stable compared with T2 measures. The half-widths of the confidence intervals for relative deviations were 3.4% for mean T1 and 8.0% for mean T2 values across scanners. Intrascanner repeatability half-widths of the confidence intervals for relative deviations were in the range of 2.0%-3.1% for T1 and 3.1%-7.9% for T2. Conclusion This study provides values on reproducibility and repeatability of T1 and T2 relaxometry measured with fast imaging with steady-state free precession MR fingerprinting in brain tissues of healthy volunteers. Reproducibility and repeatability are considerably higher in solid brain compartments than in cerebrospinal fluid and are higher for T1 than for T2. © RSNA, 2019 <i>Online supplemental material is available for this article.</i> See also the editorial by Barkhof and Parker in this issue.
Proton-Catalyzed Hydrogenation of a d8 Ir(I) Complex Yields a trans Ir(III) Dihydride (2010)

Hydrogenation of the (PONOP)Ir(I)CH(3) complex [PONOP = 2,6-bis(di-tert-butylphosphinito)pyridine] yields the unexpected trans-dihydride species (PONOP)IrCH(3)(H)(2). Mechanistic investigations have revealed that this reaction proceeds via proton-catalyzed H(2) cleavage, a pathway that circumvents the intermediacy of the typically invoked cis-dihydride isomer. Protonation yields the cationic (PONOP)Ir(CH(3))(H)(+) complex, which is then trapped by H(2) to yield an eta(2)-H(2) complex. Deprotonation of this species yields the trans-dihydride. Intermediates in the proposed pathway have been confirmed by independent low-temperature syntheses and spectroscopic observations.
A photoactivatable small-molecule inhibitor for light-controlled spatiotemporal regulation of Rho kinase in live embryos (2011)

To uncover the molecular mechanisms of embryonic development, the ideal loss-of-function strategy would be capable of targeting specific regions of the living embryo with both temporal and spatial precision. To this end, we have developed a novel pharmacological agent that can be light activated to achieve spatiotemporally limited inhibition of Rho kinase activity in vivo. A new photolabile caging group, 6-nitropiperonyloxymethyl (NPOM), was installed on a small-molecule inhibitor of Rho kinase, Rockout, to generate a 'caged Rockout' derivative. Complementary biochemical, cellular, molecular and morphogenetic assays in both mammalian cell culture and Xenopus laevis embryos validate that the inhibitory activity of the caged compound is dependent on exposure to light. Conveniently, this unique reagent retains many of the practical advantages of conventional small-molecule inhibitors, including delivery by simple diffusion in the growth medium and concentration-dependent tuneability, but can be locally activated by decaging with standard instrumentation. Application of this novel tool to the spatially heterogeneous problem of embryonic left-right asymmetry revealed a differential requirement for Rho signaling on the left and right sides of the primitive gut tube, yielding new insight into the molecular mechanisms that generate asymmetric organ morphology. As many aromatic/heterocyclic small-molecule inhibitors are amenable to installation of this caging group, our results indicate that photocaging pharmacological inhibitors might be a generalizable technique for engendering convenient loss-of-function reagents with great potential for wide application in developmental biology.
Microarray hybridization analysis of light-dependent gene expression inPenicillium chrysogenumidentifies bZIP transcription factor PcAtfA (2015)

The fungal velvet complex is a light-dependent master regulator of secondary metabolism and development in the major penicillin producer, Penicillium chrysogenum. However, the light-dependent mechanism is unclear. To identify velvet-dependent transcriptional regulators that show light-regulated expression, we performed microarray hybridizations with RNA isolated from P. chrysogenum ΔPcku70 cultures grown under 13 different long-term, light-dependent growth conditions. We compared these expression data to data from two velvet complex deletion mutants; one lacked a subunit of the velvet complex (ΔPcvelA), and the other lacked a velvet-associated protein (ΔPclaeA). We sought to identify genes that were up-regulated in light, but down-regulated in ΔPcvelA and ΔPclaeA. We identified 148 co-regulated genes that displayed this regulatory pattern. In silico analyses of the co-regulated genes identified six proteins with fungal-specific transcription factor domains. Among these, we selected the bZIP transcription factor, PcAtfA, for functional characterization in deletion and complementation strains. Our data clearly indicates that PcAtfA governs spore germination. This comparative analysis of different microarray hybridization data sets provided results that may be useful for identifying genes for future functional analyses.