gebhart/patrepeval huggingface dataset:
Dynamic Quadripolar Radiofrequency: Pilot Study of a New High-Tech Strategy for Prevention and Treatment of Vulvar Atrophy (2018)

The well-being of the vulva and a woman’s quality of life are strongly correlated. Dynamic quadripolar radiofrequency (DQRF), one of the newest nonsurgical light- and energy-based vulvar rejuvenation technologies, has been demonstrated to be an effective option in aesthetic gynecology. The aim of this study was to perform qualitative and semiquantitative evaluations of short-term changes in vulvar aesthetics to illustrate the efficacy of an accelerated DQRF vulvar rejuvenation program in women with mild to moderate vulvar atrophy. Twenty women with mild to moderate vulvar atrophy were prospectively screened and evaluated. Serial photographs documented the aesthetic impact of DQRF on the vulvar area over the 2-month study period. The overall aesthetic improvement was rated on a Global Aesthetic Improvement Scale modified to create a 10-point semiquantitative rating tool. Complications and side effects were recorded. All women successfully underwent 3 planned DQRF procedures spaced 7-10 days apart. Signs and symptoms of vulvar atrophy and the range of aesthetic judgments of the vulvar area were improved in most women after the first DQRF session, and improvements in vulvar aesthetics were persistently highly significant 1 month after the end of the DQRF rejuvenation program. No complications or side effects occurred. Improvements in the signs and symptoms of vulvar atrophy by DQRF rejuvenation of the labia majora confirm the efficacy and safety of this technically simple outpatient procedure. In women with mild to moderate atrophy, a rapid rejuvenation program of closely spaced sessions achieved significant improvements.
Large Cation−Anion Materials Based on Trinuclear Ruthenium(III) Salts of Keggin and Wells-Dawson Anions Having Water-Filled Channels (2009)

Reaction of the trinuclear ruthenium(III) cation [Ru(3)O(OOCCH(3))(6)(CH(3)OH)(3)](+) with the Keggin-type [alpha-GeW(11)O(39)](8-), [alpha-SiW(11)O(39)](8-), and [alpha-SiMo(12)O(40)](4-) and the Wells-Dawson-type [alpha-P(2)W(18)O(62)](6-) polyanions in an aqueous, acidic medium resulted in plenary polyoxometalate-based materials K(2)Na[Ru(3)O(OOCCH(3))(6)(H(2)O)(3)][alpha-GeW(12)O(40)].10H(2)O (1), K(3)[Ru(3)O(OOCCH(3))(6)(H(2)O)(3)][alpha-SiW(12)O(40)].18H(2)O (2), K(3)[Ru(3)O(OOCCH(3))(6)(H(2)O)(3)][alpha-SiMo(12)O(40)].7H(2)O (3), and K(2)Na[Ru(3)O(OOCCH(3))(6)(H(2)O)(3)](3)[alpha-P(2)W(18)O(62)].26H(2)O (4), respectively. All four materials, 1-4, crystallize as sodium and/or potassium salts in the monoclinic space group P2(1)/n. Compounds 1-4 were characterized by IR, thermogravimetric analysis, and single-crystal/powder X-ray diffraction (XRD). The isolated solid-state frameworks, composed of cocrystallized trinuclear ruthenium cations and polyanions, exhibit nanosized voids filled with crystal waters. These water molecules can be removed reversibly upon heating under a vacuum, and powder XRD measurements demonstrated that the crystallinity of the compound was preserved. Sorption studies on ethanol and methanol were also performed.
Intermetallic Copper‐Based Electride Catalyst with High Activity for C–H Oxidation and Cycloaddition of CO2 into Epoxides (2022)

Abstract Inorganic electrides have been proved to be efficient hosts for incorporating transition metals, which can effectively act as active sites giving an outstanding catalytic performance. Here, it is demonstrated that a reusable and recyclable (for more than 7 times) copper‐based intermetallic electride catalyst (LaCu 0.67 Si 1.33 ), in which the Cu sites activated by anionic electrons with low‐work function are uniformly dispersed in the lattice framework, shows vast potential for the selective C–H oxidation of industrially important hydrocarbons and cycloaddition of CO 2 with epoxide. This leads to the production of value‐added cyclic carbonates under mild reaction conditions. Importantly, the LaCu 0.67 Si 1.33 catalyst enables much higher turnover frequencies for the C–H oxidation (up to 25 276 h –1 ) and cycloaddition of CO 2 into epoxide (up to 800 000 h –1 ), thus exceeding most nonnoble as well as noble metal catalysts. Density functional theory investigations have revealed that the LaCu 0.67 Si 1.33 catalyst is involved in the conversion of N‐hydroxyphthalimide (NHPI) into the phthalimido‐N‐oxyl (PINO), which then triggers selective abstraction of an H atom from ethylbenzene for the generation of a radical susceptible to further oxygenation in the presence of O 2 .
Control of Channel Power Instabilities in Transparent Networks Using Scalable Mesh Scheduling (2007)

Experiments on transparent, constant-gain-controlled amplifier networks show that WDM channel-power instability, which grows from competing adjustments on multiple nodes, can be controlled. Simulations demonstrate a fast, stable node control algorithm scalable to large mesh networks.
Stereocomplementary synthesis of casuarine and its 6-epi-, 7-epi-, and 6,7-diepi-stereoisomers (2021)

Four diastereomers belonging to the family of casuarines, including casuarine (1), 6-<i>epi</i>-casuarine (2), 7-<i>epi</i>-casuarine (13) and 6,7-di<i>epi</i>-casuarine (14), have been synthesized from D-arabinose-derived cyclic nitrone 7 and nitrone-derived aldehyde 4 by a stereocomplementary strategy. Glycosidase inhibition comparison showed that 6-<i>epi</i>-casuarine (2) exhibits enhanced inhibition of trehalase (IC<sub>50</sub> = 9.7 μM) and 6,7-di<i>epi</i>-casuarine (14) leads to specific inhibition of trehalase.
Synthesis of Porous Silicon Nitride Ceramic with a Compositional Gradient (2009)

This paper summarises results of a study on graded surface layer composition in porous silicon nitride ceramics with a nominal Yb-silicate, Yb2SiO5-additive content of 3.2 mol%, corresponding to 10wt%. A compositional gradient of the additive is formed within the sintered part, depending upon the sintering conditions. The thickness and the phase content of the compositional gradient is significantly affected by the nitrogen activity of the sintering atmosphere. When argon gas is used during heating up and replaced by nitrogen upon soaking, the surface of the sintered ceramic is free of Yb2SiO5, whereas in N2-atmosphere a silicate-rich coating is found as surface layer of the porous silicon nitride ceramic. In presence of carbon and nitrogen, the surface is covered by SiC. In particular the Yb-silicate enriched surface layer can be used as base for an Environmental Barrier Coating, EBC, to protect the interior of the ceramic from hot gas corrosion.
Clusterin overexpression in both malignant and nonmalignant prostate epithelial cells induces cell cycle arrest and apoptosis (2004)

Expression of the castration-induced clusterin protein is incompatible with the survival of human prostate cancer cells in tissues and in cell culture. To investigate the fate of human prostate epithelial cells, when engineered to maintain expression of clusterin protein, we have used an IRES-hyg vector and hygromycin selection. PC-3 prostate tumour cells were substantially more sensitive to clusterin expression than nonmalignant PNT1a cells, showing multiple phenotypic changes including cell cycle arrest and increased apoptosis. The results strengthen the hypothesis that clusterin expression is proapoptotic. Expression of exogenous clusterin in both cell types resulted in its relocation from the cytoplasm and a nuclear accumulation of the protein, as was also seen in the same cells when apoptosis was induced by etoposide treatment. To survive clusterin expression, the PC-3 tumour cells developed apoptosis-inhibitory properties. This could have significance for the resistance of prostate cancers to chemo/radiotherapy, where clusterin overexpression is observed.
Matching pursuit of images (2002)

A crucial problem in image analysis is to construct efficient low-level representations of an image, providing informations on features such as edges and texture components. An image usually contains very different types of features, which have been successfully modelized by the very redundant family of 2D Gabor functions. However, this model generates representations with a very large size. Instead of decomposing a given image over this whole set of Gabor functions, we use an adaptative algorithm to select a subset of Gabor elements that are best adapted to the image. This produces compact representation in terms of few features that reveal the local image properties.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The TSC-mTOR pathway regulates macrophage polarization (2013)

Macrophages are able to polarize to proinflammatory M1 or alternative M2 states with distinct phenotypes and physiological functions. How metabolic status regulates macrophage polarization remains not well understood, and here we examine the role of mTOR (Mechanistic Target of Rapamycin), a central metabolic pathway that couples nutrient sensing to regulation of metabolic processes. Using a mouse model in which myeloid lineage specific deletion of Tsc1 (Tsc1Δ/Δ) leads to constitutive mTOR Complex 1 (mTORC1) activation, we find that Tsc1Δ/Δ macrophages are refractory to IL-4 induced M2 polarization, but produce increased inflammatory responses to proinflammatory stimuli. Moreover, mTORC1-mediated downregulation of Akt signaling critically contributes to defective polarization. These findings highlight a key role for the mTOR pathway in regulating macrophage polarization, and suggest how nutrient sensing and metabolic status could be “hard-wired ” to control of macrophage function, with broad implications for regulation of Type 2 immunity, inflammation, and allergy.
High Resolution Large Area Nanopatterning for Plasmonics and Metamaterials with Nanostencil Lithography (2011)

We demonstrate a versatile fabrication approach for high-resolution, large area patterning of optical antennas and metamaterials with reusable nanostencils. This technique offers simple and high-throughput fabrication scheme for any geometric design on variety of substrates.
An evaluation of error confidence interval estimation methods (2004)

Reporting the accuracy performance of pattern recognition systems (e.g., biometrics ID system) is a controversial issue and perhaps an issue that is not well understood. This work focuses on the research issues related to the oft used confidence interval metric for performance evaluation. Using a biometric (fingerprint) authentication system, we estimate the false reject rates and false accept rates of the system using a real fingerprint dataset. We also estimate confidence intervals of these error rates using a number of parametric and non-parametric (e.g., bootstrapping) methods. We attempt to assess the accuracy of the confidence intervals based on estimate and verify strategy applied to repetitive random train/test splits of the dataset. Our experiments objectively verify the hypothesis that the traditional bootstrap and parametric estimate methods are not very effective in estimating the confidence intervals and magnitude of interdependence among data may be one of the reasons for their ineffective estimates. Further, we demonstrate that the resampling the subsets of the data samples (inspired from moving block bootstrap) may be one way of replicating interdependence among the data; the bootstrapping methods using such subset resampling may indeed improve the accuracy of the estimates. Irrespective of the method of estimation, the results show that the (1-/spl alpha/) 100% confidence intervals empirically estimated from the training set capture significantly smaller than (1-/spl alpha/) fraction of the estimates obtained from the test set.
Nanodrug delivery platform for glucocorticoid use in skeletal muscle injury (2018)

Glucocorticoids are utilized for their anti-inflammatory properties in the skeletal muscle and arthritis. However, the major drawback of use of glucocorticoids is that it leads to senescence and toxicity. Therefore, based on the idea that decreasing particle size allows for increased surface area and bioavailability of the drug, in the present study, we hypothesized that nanodelivery of dexamethasone will offer increased efficacy and decreased toxicity. The dexamethasone-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles were prepared using nanoprecipitation method. The morphological characteristics of the nanoparticles were studied under scanning electron microscope. The particle size of nanoparticles was 217.5 ± 19.99 nm with polydispersity index of 0.14 ± 0.07. The nanoparticles encapsulation efficiency was 34.57% ± 1.99% with in vitro drug release profile exhibiting a sustained release pattern over 10 days. We identified improved skeletal muscle myoblast performance with improved closure of the wound along with increased cell viability at 10 nmol/L nano-dexamethasone-PLGA. However, dexamethasone solution (1 μmol/L) was injurious to cells because the migration efficiency was decreased. In addition, the use of dexamethasone nanoparticles decreased lipopolysaccharide-induced lactate dehydrogenase release compared with dexamethasone solution. Taken together, the present study clearly demonstrates that delivery of PLGA-dexamethasone nanoparticles to the skeletal muscle cells is beneficial for treating inflammation and skeletal muscle function.
Packaging of high density fiber/laser modules using passive alignment techniques (1992)

A method for packaging a laser-fiber module is explored in which the critical laser-fiber alignment is carried out, not with the laser activated, but by a passive method based on the registration principles of photolithography. The method relies on an index scheme in which fiducial marks are lithographically placed on the laser chip and on a fiber carrier. At 850 nm, using the index technique with cleaved multimode fibers, it was possible to achieve the same laser-fiber coupling efficiency as attained by active alignment; with cleaved single-mode fibers about 80% of the active alignment coupling efficiency was achieved. Details of the index-alignment method are discussed, and a brief description of an improved computer-controlled version of the apparatus is given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Latarjet-Bristow Procedure for Recurrent Anterior Instability (2000)

1Clinique Sainte Anne Lumière Lyon, France 2Hôpital de l'Archet Nice, France Address correspondence and reprint requests to Dr. Gilles Walch, Clinique Sainte Anne Lumière, 85 Cours Albert Thomas, 69003 Lyon, France. E-mail: [email protected]
A Low Overpotential Mechanism for the Efficient Electrochemical Conversion of Carbon Dioxide and Water to Methanol (2010)

Abstract not Available.
Clonal immunoglobulin DNA in the plasma of patients with AIDS lymphoma (2011)

Immunoglobulin (Ig) gene rearrangements are used to define clonality of suspected B-lineage malignancy in tissue samples. To determine whether such rearrangements could be identified in plasma, we screened plasma from 14 consecutive patients with AIDS-related lymphoma with multiplex Ig primers. Clonally rearranged Ig DNA was detected in plasma from 7 of 14 patients. Patients in whom clonal Ig DNA remained detectable after combination chemotherapy died with lymphoma. Tumor was available from 1 patient, and the IgH amplification products from plasma and tumor were sequenced and confirmed to be identical. Ig DNA rearrangements in plasma may be useful as a lymphoma-specific tumor marker, and failure to clear clonal Ig DNA may identify patients at high risk for failure of standard therapy.
Surgical Site Infections in Pediatric Spine Surgery (2015)

S. aureus is the first cause of SSI in pediatric spine surgery. However, Gram-positive anaerobic cocci should be taken into account in idiopathic patients and GNB in nonidiopathic patients when considering antibiotic prophylaxis and curative treatment.
Performance of In&lt;inf&gt;0.53&lt;/inf&gt;Ga&lt;inf&gt;0.47&lt;/inf&gt;As/InP avalanche photodiodes (1982)

We calculate operating characteristics of high-sensitivity high-speed In <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.53</inf> Ga <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.47</inf> As/InP avalanche photodiodes (APD's). We find that significant photocurrent gain is obtained for a total fixed-charge density of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\sigma_{tot} &gt; 3 \times 10^{12}</tex> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> in the depleted InP and <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.53</inf> Ga <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.47</inf> As regions. To obtain high quantum efficiency and low tunneling currents, the fixed-charge density in the InP must be in the range <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2 \times 10^{12}</tex> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\leq \sigma_{B} \leq 3 \times 10^{12}</tex> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> . We calculate the breakdown voltages for APD's with uniformly doped layers and find that practical detectors with avalanche breakdowns as low as 15 V can be realized. High quantum efficiency and fast response are obtained by compositional grading of the In <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.53</inf> Ga <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.47</inf> As heterointerface over a distance of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">L \gsim 380</tex> Å, depending on the doping and amount of the In <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.53</inf> Ga <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.47</inf> As layer swept out at breakdown. Finally, a comparison of calculations with experimental results is presented.
Renal Metabolism of 3‘-Iodohippuryl Nε-Maleoyl-l-lysine (HML)-Conjugated Fab Fragments (2001)

Renal localization of radiolabeled antibody fragments constitutes a problem in targeted imaging and radiotherapy. Recently, we reported use of a novel radioiodination reagent, 3'-[131I]iodohippuryl N(epsilon)-maleoyl-L-lysine (HML), that liberates m-iodohippuric acid before antibody fragments are incorporated into renal cells. In mice, HML-conjugated Fab demonstrated low renal radioactivity levels from early postinjection times. In this study, renal metabolism of HML-conjugated Fab fragments prepared by different thiolation chemistries and by direct radioiodination were investigated to determine the mechanisms responsible for the low renal radioactivity levels. Fab fragments were thiolated by 2-iminothiolane modification or by reduction of disulfide bonds in the Fab fragments, followed by conjugation with radioiodinated HML to prepare [131I]HML-IT-Fab and [125I]HML-Fab, respectively. In biodistribution studies in mice, both [131I]HML-IT-Fab and [125I]HML-Fab demonstrated significantly lower renal radioactivity levels than those of [125I]Fab. In subcellular distribution studies, [125I]Fab showed migration of radioactivity from the membrane to the lysosomal fraction of the renal cells from 10 to 30 min postinjection. On the other hand, the majority of the radioactivity was detected only in the membrane fraction at the same time points after injection of both [131I]HML-IT-Fab and [125I]HML-Fab. In metabolic studies, while [125I]Fab remained intact at 10 min postinjection, both HML-conjugated Fab fragments generated m-iodohippuric acid as a radiometabolite at the same postinjection time. [131I]HML-IT-Fab registered two radiometabolites (intact [131I]HML-IT-Fab and m-iodohippuric acid), whereas additional radiometabolites were observed with [125I]HML-Fab. This suggested that metabolism of both HML-conjugated Fab fragments would occur in the membrane fractions of the renal cells. The findings of this study reinforced our previous hypothesis that radiochemical design of antibody fragments that liberate radiometabolites that are excreted into the urine by the action of brush border enzymes would constitute a useful strategy to reduce renal radioactivity levels from early postinjection times.
Nonwoven Polymer Nanofiber Coatings That Inhibit Quorum Sensing in Staphylococcus aureus: Toward New Nonbactericidal Approaches to Infection Control (2017)

We report the fabrication and biological evaluation of nonwoven polymer nanofiber coatings that inhibit quorum sensing (QS) and virulence in the human pathogen Staphylococcus aureus. Our results demonstrate that macrocyclic peptide 1, a potent and synthetic nonbactericidal quorum sensing inhibitor (QSI) in S. aureus, can be loaded into degradable polymer nanofibers by electrospinning and that this approach can deposit QSI-loaded nanofiber coatings onto model nonwoven mesh substrates. The QSI was released over ∼3 weeks when these materials were incubated in physiological buffer, retained its biological activity, and strongly inhibited agr-based QS in a GFP reporter strain of S. aureus for at least 14 days without promoting cell death. These materials also inhibited production of hemolysins, a QS-controlled virulence phenotype, and reduced the lysis of erythrocytes when placed in contact with wild-type S. aureus growing on surfaces. This approach is modular and can be used with many different polymers, active agents, and processing parameters to fabricate nanofiber coatings on surfaces important in healthcare contexts. S. aureus is one of the most common causative agents of bacterial infections in humans, and strains of this pathogen have developed significant resistance to conventional antibiotics. The QSI-based strategies reported here thus provide springboards for the development of new anti-infective materials and novel treatment strategies that target virulence as opposed to growth in S. aureus. This approach also provides porous scaffolds for cell culture that could prove useful in future studies on the influence of QS modulation on the development and structure of bacterial communities.
Reduction of Surfactant Adsorption in Porous Media Using Silica Nanoparticles (2018)

Abstract In surfactant flooding for enhanced oil recovery, adsorption of surfactants on the porous media of an oil reservoir is a major concern. It weakens the efficacy of the injected surfactant in reducing oil–water interfacial tension (IFT) and makes the oil recovery process uneconomical. Colloidal silica nanoparticles were found to adsorb at a lower rate than surfactant in porous media because of their charge density and high surface area. Silica nanoparticle surfaces with a negative surface charge are expected to adsorb onto the same active sites in the reservoir as anionic surfactant molecules used in enhanced oil recovery (EOR) applications. Experiments conducted in sandpack demonstrated that pre-treatment of the sandpack with silica nanoparticles at 80°C reduced surfactant adsorption by a factor of three when using artificial seawater as the injection fluid.