gebhart/patrepeval huggingface dataset:
Changes in Extracellular Amino Acids and Spontaneous Neuronal Activity During Ischemia and Extended Reflow in the CA1 of the Rat Hippocampus (1991)

This study addresses the possible involvement of an agonist-induced postischemic hyperactivity in the delayed neuronal death of the CA1 hippocampus in the rat. In two sets of experiments, dialytrodes were implanted into the CA1 either acutely or chronically (24 h of recovery). During 20 min of cerebral ischemia (four-vessel occlusion model) and 8 h of reflow, we followed extracellular amino acids and multiple-unit activity. Multiple-unit activity ceased within 20 sec of ischemia and remained zero during the ischemic insult and for the following 1 h of reflow. During ischemia, extracellular aspartate, glutamate, taurine, and gamma-aminobutyric acid increased in both acute and chronic experiments (seven- to 26-fold). Multiple-unit activity recovered to preischemic levels following 4-6 h of reflow. In the group with dialytrodes implanted acutely, the continuous increase in multiple-unit activity reached 110% of basal at 8 h of reflow. In the group with dialytrodes implanted chronically, multiple-unit activity recovered faster and reached 140% of control at 8 h, paralleled by an increase in extracellular aspartate (5.5-fold) and glutamate (twofold). In conclusion, the postischemic increase of excitatory amino acids and the recovery of the neuronal activity may stress the CA1 pyramidal cells, which could be detrimental in combination with, e.g., postsynaptic impairments.
Age‐related differences in symptoms in older emergency department patients with COVID ‐19: Prevalence and outcomes in a multicenter cohort (2022)

Older patients with COVID-19 are more likely to have presentations without the most common symptoms. However, alternate presentations of COVID-19 in older ED patients are not associated with greater odds of mechanical ventilation and/or death. Our data highlights the importance of a liberal COVID-19 testing strategy among older ED patients to facilitate accurate diagnoses and timely treatment and prophylaxis.
Editorial Comments (1991)

No AccessJournal of Urology1 Jun 1991Editorial Comments Glenn M. Preminger Glenn M. PremingerGlenn M. Preminger More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)38633-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial Comments." The Journal of Urology, 145(6), pp. 1144–1145 © 1991 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 145Issue 6June 1991Page: 1144-1145 Advertisement Copyright & Permissions© 1991 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Glenn M. Preminger More articles by this author Expand All Advertisement Loading ...
Morphology templating of nanofibrous silica through pH-sensitive gels: “in situ” and “post-diffusion” strategies (2006)

A pH-sensitive pyridine-based gelator has been found as a flexible and efficient template for the transcription of nanofibrous silica. The morphology and aggregation degree of silica nanofibers and nanotubes (30–60 nm thick, with 3–10 nm inner channels) could be tuned by simply adjusting the pH conditions through the use of “in situ” formed organogels. Interestingly, silica nanotubes with larger inner mesoporous channels (5–35 nm) were obtained by using a “post-diffusion” route instead of the conventional “one pot” or in situ strategy. Preliminary results about the templating of nanofibrous Fe-based hybrid xerogels are also shown, suggesting that this family of gelators could be used to design nanofibers and nanotubes of more complex inorganic phases.
A framework for multiplex imaging optimization and reproducible analysis (2022)

Multiplex imaging technologies are increasingly used for single-cell phenotyping and spatial characterization of tissues; however, transparent methods are needed for comparing the performance of platforms, protocols and analytical pipelines. We developed a python software, mplexable, for reproducible image processing and utilize Jupyter notebooks to share our optimization of signal removal, antibody specificity, background correction and batch normalization of the multiplex imaging with a focus on cyclic immunofluorescence (CyCIF). Our work both improves the CyCIF methodology and provides a framework for multiplexed image analytics that can be easily shared and reproduced.
Defect studies of resist process for 193nm immersion lithography (2006)

193nm immersion lithography is the most promising lithographic technology for the semiconductor device manufacturing of 65nm node and below. The advantage of 193nm immersion lithography is the possibility of wider depth of focus (DOF) and higher resolution through the hyper NA lens design greater than 1.0<sup>(1-3)</sup>. In this paper, we investigated the topcoat material film characteristics and evaluated its performance to determine the chemical properties needed for a practical level. The stage scan speed capability evaluation, which is one of the best available method to test the suppression or generation of small water droplet remains on the topcoat film at high-speed stage scan during immersion exposure, was used. And finally we investigated the defectivity of topcoat process utilizing the Nikon EET. The static and dynamic contact angles of water droplet were investigated to characterize the topcoat material. The tilting sliding and receding angle, the contact angle of water droplet at the dynamic state, were important parameters to characterize the topcoat materials and have good correlation to wafer stage scan speed capability and immersion defect count reduction.
Dual-Gated Microparticles for Switchable Antibody Release (2017)

We pioneer the design of dual-gated microparticles, both responsive to changes in temperature and pH, for stimuli-responsive chromatography targeted at the efficient separation of antibodies. Dual-gated microspheres were synthesized by introducing RAFT-based thiol-terminal block copolymers of poly(N-isopropylacrylamide-b-4-vinylpyridine) (P(NIPAM-b-4VP, 4800 ≤ Mn/Da ≤ 10 000, featuring block length ratios of 29:7, 29:15, and 29:30, respectively) by thiol-epoxy driven ligation to the surface of poly(glycidyl methacrylate) (PGMA) microparticles (10–12 μm), whereby the 4-vinylpyridine units within the lateral chain enable protein binding. The switchable protein release abilities of the resulting microparticle resins are demonstrated by adsorption of immunoglobulins at 40 °C and pH 8 and their release at 5 °C or pH 3, respectively. We demonstrate that P(NIPAM29-b-4VP30)-grafted PGMA particles show a maximum adsorption capacity for immunoglobulins of 18.9 mg mL–1 settled resin at 40 °C/pH 8, whereas the adsorption capacity decreased to 7.5 mg mL–1 settled resin at 5 °C while retaining the pH value, allowing the unloading of the chromatographic column by a facile temperature switch. Critically, regeneration of the dual-gated microspheres became possible by lowering the pH to 3.
Full Poincaré polarimetry enabled through physical inference (2022)

While polarization sensing is vital in many areas of research, with applications spanning from microscopy to aerospace, traditional approaches are limited by method-related error amplification, accumulation, and pre-processing steps, constraining the performance of single-shot polarimetry. Here, we propose a measurement paradigm that circumvents these limitations, based on the use of a universal full Poincaré generator to map all polarization analyzer states into a single vectorially structured light field. All vector components are analyzed in a single shot, extracting the vectorial state through inference from a physical model of the resulting image, providing a single-step sensing procedure. To demonstrate the feasibility of our approach, we use a common graded index (GRIN) optic as our mapping device and show mean errors of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mo>&lt;</mml:mo> </mml:mrow> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mn>1</mml:mn> </mml:mrow> <mml:mi mathvariant="normal">%</mml:mi> </mml:math> for each vector component. Our work paves the way for next-generation polarimetry, impacting a wide variety of applications that rely on vector measurement.
Electrically Tunable Photoresponse in a Graphene Heterostructure Photodetector (2017)

We report an electrically tunable photodetector design based on photogating effect in graphene heterostructures. We demonstrate electrically tunable photoresponse up to 60 A/W with a sub-millisecond speed. The detector's spectra tunability will also be investigated.
Minimally Invasive Thoracic Corpectomy (2013)

Smith, Zachary A. MD*; Wong, Albert P. MD*; El Ahmadieh, Tarek Y. MD*; Aoun, Salah G. MD*; Haque, Raqeeb MD*; Bendok, Bernard B. MD*; Fessler, Richard G. MD, PhD* Author Information
La calréticuline détermine l’immunogénicité de la chimiothérapie et de la radiothérapie antitumorales (2007)

> La chimiotherapie est utilisee en clinique afin d’induire la mort des cellules cancereuses et parvenir ainsi a faire regresser les tumeurs. Bien que les effets cytotoxiques antitumoraux directs de la chimiotherapie soient bien connus, les consequences indirectes de l’action des agents cytotoxiques et en particulier le declenchement d’une reponse immunitaire de l’hote contre sa tumeur n’ont ete que tres recemment decrits. C’est l’objectif de ce texte d’expliquer cette nouvelle notion de chimiotherapie immunogene puis d’evoquer les implications cliniques potentielles d’une decouverte tres recente qui a permis de mettre en evidence les mecanismes moleculaires responsables de l’immunogenicite des cellules cancereuses mourantes.
Electrical conductivity of a pure C60 single crystal (1992)

The temperature dependence of the electrical conductivity of a C60 single crystal is presented in this letter. The single-crystal samples free from solvent contamination were grown up to a size of millimeters order by sublimation of C60 powder with oscillation of the crystal temperature. The electrical conductivity of the single crystal was measured at temperatures between 250 and 295 K. The sharp decrease of the electrical conductivity with temperature around 256 K was observed in association with the phase transition of C60.
Multifunctional MXene/C Aerogels for Enhanced Microwave Absorption and Thermal Insulation (2023)

Two-dimensional transition metal carbides and nitrides (MXene) have emerged as promising candidates for microwave absorption (MA) materials. However, they also have some drawbacks, such as poor impedance matching, high self-stacking tendency, and high density. To tackle these challenges, MXene nanosheets were incorporated into polyacrylonitrile (PAN) nanofibers and subsequently assembled into a three-dimensional (3D) network structure through PAN carbonization, yielding MXene/C aerogels. The 3D network effectively extends the path of microcurrent transmission, leading to enhanced conductive loss of electromagnetic (EM) waves. Moreover, the aerogel's rich pore structure significantly improves the impedance matching while effectively reducing the density of the MXene-based absorbers. EM parameter analysis shows that the MXene/C aerogels exhibit a minimum reflection loss (RL<sub>min</sub>) value of - 53.02 dB (f = 4.44 GHz, t = 3.8 mm), and an effective absorption bandwidth (EAB) of 5.3 GHz (t = 2.4 mm, 7.44-12.72 GHz). Radar cross-sectional (RCS) simulations were employed to assess the radar stealth effect of the aerogels, revealing that the maximum RCS reduction value of the perfect electric conductor covered by the MXene/C aerogel reaches 12.02 dB m<sup>2</sup>. In addition to the MA performance, the MXene/C aerogel also demonstrates good thermal insulation performance, and a 5-mm-thick aerogel can generate a temperature gradient of over 30 °C at 82 °C. This study provides a feasible design approach for creating lightweight, efficient, and multifunctional MXene-based MA materials.
The IPL Gene on Chromosome 11p15.5 is Imprinted in Humans and Mice and is Similar to TDAG51, Implicated in Fas Expression and Apoptosis (1997)

We searched for novel imprinted genes in a region of human chromosome 11p15.5, which contains several known imprinted genes. Here we describe the cloning and characterization of the IPL ( I mprinted in P lacenta and L iver) gene, which shows tissue-specific expression and functional imprinting, with the maternal allele active and the paternal allele relatively inactive, in many human and mouse tissues. Human IPL is highly expressed in placenta and shows low but detectable expression in fetal and adult liver and lung. Mouse Ipl maps to the region of chromosome 7 which is syntenic with human 11p15.5 and this gene is expressed in placenta and at higher levels in extraembryonic membranes (yolk sac), fetal liver and adult kidney. Mouse and human IPL show sequence similarity to TDAG51 , a gene which was shown to be essential for Fas expression and susceptibility to apoptosis in a T lymphocyte cell line. Like several other imprinted genes, mouse and human IPL genes are small and contain small introns. These data expand the repertoire of known imprinted genes and will be helpful in testing the mechanism of genomic imprinting and the role of imprinted genes in growth regulation.
ShearWave&#x2122; Elastography A new real time imaging mode for assessing quantitatively soft tissue viscoelasticity (2008)

ShearWavetrade Elastography (SWE) is a new real time ultrasound imaging mode that quantitatively measures local tissue elasticity in kPa. Based on the Supersonic Shear Imaging concept (developed at the Laboratoire Ondes et Acoustique, Paris), this new concept may appear as a promising tool to improve breast lesion characterization. In vitro experimental measurements have been performed to quantify SWE mode performances in terms of resolution, penetration and the ability to measure quantitatively elasticity. Results show that the SWE mode exhibits a millimetric resolution and quantifies properly tissue elasticity on a wide range of elastic contrasts (from 7 to 110 kPa). The real time capabilities and the robustness of the mode have been tested in clinical conditions, on breast lesions. 150 patients have been scanned with SWE mode in three different sites. Results show that SWE performs well on breast pathologies and presents a very good inter-site reproducibility. Finally, the quantitative elasticity value was analyzed as a function of pathology using FNA or core biopsy as the reference diagnostic method.
Experimental Comparison Between Hepatic Artery Infusion and Occlusion-Infusion of Adriamycin (1987)

Adult mongrel dogs were used to compare hepatic arterial infusion and arterial occlusion-infusion with regard to local and systemic Adriamycin levels. The drug was infused into the right proper hepatic artery of each dog after occlusion of the gastroduodenal artery. Blood and tissue samples were collected at regular intervals for Adriamycin determination. Four weeks later, each dog again received the same agent in the right proper hepatic artery, but this time arterial flow was blocked with an inflated balloon during drug infusion (arterial occlusion-infusion). Blood and tissue drug levels were determined and compared with those obtained using infusion without occlusion. Results indicate that when Adriamycin is administered into the hepatic artery of dogs, occlusion-infusion produces significantly greater hepatic venous drug levels, drug uptake, and drug metabolism than does infusion alone.
X-ray photoelectron spectroscopy study of the Ni/Si oxide/Si interface (1987)

The electronic structure of the Ni/Si oxide/Si interface has been investigated using x-ray photoelectron spectroscopy. This interface represents a more realistic situation encountered in semiconductor device processing technology. Approximately 35 Å of high-purity Ni was sputter deposited on 〈111〉Si (covered with a thin native oxide layer) at room temperature. A sputter profiling technique was employed to determine the composition and reactivity as a function of depth. The measurements show considerable reactivity at the Ni/Si oxide/Si interface, even at room temperature. The Ni 2p3/2 peak exhibits a gradual shift to higher binding energy which indicates that the overlayer cannot be regarded as a single unique nickel silicide phase. The large positive shift of the Ni 2p3/2 and the small shift of the corresponding Si 2p peak suggest that ionicity plays a nominal role in the Ni–Si chemical bond. The valence-band spectra show a dominant 3d-derived feature which gradually shifts to higher binding energy. The observed shifts in the Ni levels are attributed to the change in the electronic configuration of Ni in going from Ni-rich silicide to Si-rich silicide. A study of the composition as a function of depth shows that the Ni/Si oxide/Si interface is not sharply defined due to the interdiffusion of Ni and Si. Thus, the interface is identified as a graded transition region with composition ranging from Ni-rich to Si-rich silicide.
Interruption of Treatment with Individual Therapeutic Drug Classes in Adults with Multidrug‐Resistant HIV‐1 Infection (2005)

Background. Many antiretroviral‐treated human immunodeficiency virus (HIV)–infected patients experience sustained immunologic and virologic benefit despite the presence of multidrug‐resistant HIV. We hypothesized that the use of simplified regimens could maintain treatment benefit while preventing viral evolution and reducing drug‐related toxicity and costs. Methods. We conducted a 48‐week nonrandomized study of adults with multidrug‐resistant HIV type 1 infection. Subjects interrupted protease inhibitor (PI) (⁠n=18⁠), reverse‐transcriptase inhibitor (RTI) (⁠n=6⁠), or nonnucleoside RTI (NNRTI) (⁠n=6⁠) treatment. Results. At study entry, subjects had a median reduction in HIV RNA levels of 1.2 log10 copies/mL relative to pretreatment levels. Interruption of PI treatment was associated with stable HIV RNA levels (mean change per week, +0.005 log10 copies/mL; P=.36⁠). PI mutations waned and replicative capacity and HIV RNA levels increased after long‐term observation. HIV RNA levels also remained stable in subjects interrupting NNRTI treatment. In contrast, all subjects who interrupted RTI treatment exhibited immediate increases in HIV RNA levels, and most exhibited a subsequent loss of the M184V mutation. Conclusions. These data indicate that nucleoside analogues often exert continued antiviral activity in the setting of drug‐resistance mutations and that both nucleoside analogues and PIs can select for drug‐resistance mutations that reduce viral fitness. These observations support the evaluation of treatment strategies aimed at maintaining the treatment benefit of therapy while reducing drug exposure.
Transcatheter tricuspid valve‐in‐valve in patients with transvalvular device leads (2015)

Transcatheter tricuspid valve-in-valve is feasible in patients with pre-existing transvalvular devices leads. Further study is required to determine the long-term clinical implications of this treatment approach.
Hysteresis-free switching between vortex and collinear magnetic states (2014)

We demonstrate a lossless switching between vortex and collinear magnetic states in circular FePd disks arranged in a square lattice. Above a bifurcation temperature (Te) we show that thermal fluctuations are enough to facilitate flipping between the two distinctly different magnetic states. We find that the temperature dependence of the vortex annihilation and nucleation fields can be described by a simple power law relating them to the saturation magnetization.
Induction of ermSV by 16-membered-ring macrolide antibiotics (1997)

The erm family of 23S rRNA adenine-N6-methyltransferases confers resistance to all macrolide-lincosamide-streptograminB (MLS) antibiotics, but not all MLS antibiotics induce synthesis of Erm methyltransferase with equal efficiency in a given organism. The induction efficiency of a test panel of MLS antibiotics was studied by using two translational attenuator-lac reporter gene fusion constructs, one based on ermSV from Streptomyces viridochromogenes NRRL 2860 and the other based on ermC from Staphylococcus aureus RN2442. Four types of responses which were correlated with the macrolide ring size were seen, as follows: group 1, both ermSV and ermC were induced by the 14-membered-ring macrolides erythromycin, lankamycin, and matromycin, as well as by the lincosamide celesticetin; group 2, neither ermSV nor ermC was induced by the 12-membered-ring macrolide methymycin or by the lincosamide lincomycin or the streptogramin type B antibiotic ostreogrycin B; group 3, ermSV was selectively induced over ermC by the 16-membered-ring macrolides carbomycin, chalcomycin, cirramycin, kitasamycin, maridomycin, and tylosin; and group 4, ermC was selectively induced over ermSV by the 14-membered-ring macrolide megalomicin. These data suggest that the leader peptide determines the specificity of induction by different classes of MLS antibiotics and that for a given attenuator, a major factor which determines whether a given macrolide induces resistance is its size.
Regression of Kayser-Fleischer Rings During Oral Zinc Therapy (1996)

Fourteen patients presenting with neuropsychiatric manifestations of Wilson's disease were treated with oral tetrathiomolybdate (TM) for 8 weeks followed by oral zinc (Zn) maintenance therapy. The patients were evaluated prospectively at baseline and at yearly intervals for up to 5 years by slit-lamp biomicroscopy and photography, quantitative neurologic and speech pathology examinations, 24-h urine copper collection, and a quantitative scoring of magnetic resonance imaging (MRI) of the brain. Kayser-Fleischer (KF) ring size decreased significantly during the 5-year study period (p < 0.0001). Although results of neurologic examination, speech pathology examination, and 24-h urine copper level analysis in symptomatic Wilson's disease patients improved during the study period, KF ring regression did not correlate with the improvement in these clinical parameters (p > 0.05). However, there was a correlation between MRI scores and KF ring regression (p = 0.02). Anticopper therapy with TM followed by zinc maintenance therapy is a safe and effective treatment for patients with neurologically symptomatic Wilson's disease. This treatment leads to reduction in KF ring size; however, KF ring reduction is not a good predictor of clinical improvement for patients with neuropsychiatric manifestations of Wilson's disease.