gebhart/patrepeval huggingface dataset:
Pulmonary Injury Elicited by Blood: An Experimental Study (1979)

To examine the role of cellular and humoral (serotonin, histamine) changes of blood after contact with foreign surfaces in the production of pulmonary injury, homologous whole blood (WB), leukocyte-poor blood (LPB) and leukocyte- and platelet-poor blood (LPPB) were perfused through the isolated rabbit lung or recirculated through the perfusion circuit without lung. Perfusion with WB was accompanied by an increase in pulmonary vascular resistance and deterioration of pulmonary gas exchange function within 60 min. Microscopic examination of WB-perfused lung revealed perivascular and alveolar hemorrhage, edema and microaggregates. Morphometrically, pulmonary arteries and arterioles exhibited narrowed vascular lumina and thickened muscular walls, indicating precapillary vasoconstriction as a primary event underlying the observed pathological changes. With LPPB or LPB no significant functional or morphological changes were seen. Granulocytes, which were sequestered by the isolated lung, represent an essential factor in eliciting significant pulmonary damage. No direct damaging effects of serotonin or histamine could be demonstrated in the absence of white blood cells.
The Philadelphia chromosome in human macrophages (1977)

Three patients with chronic myelocytic leukemia in different phases of the natural history of the disease were studied. Their bone marrow cells were cultured under conditions favoring macrophage proliferation, and parallel cytogenetic and cytochemical studies were performed. All cell metaphases examined contained the Ph1 chromosome at a time when more than 80% of these metaphases were in identifiable macrophages. We conclude that the mononuclear phagocyte cell line contains the abnormal chromosome in Ph1-positive chronic myelocytic leukemia.
Figure S2 from LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma (2023)

&lt;p&gt;Figure S2. Phosphorylation of human TPI1 is LKB1-dependent.&lt;/p&gt;
Supplemental Figure 5 from Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer (2023)

&lt;p&gt;Supplemental Figure 5&lt;/p&gt;
Multi-Phase Finite Element Modeling of Machining Unidirectional Fiber Reinforced Composites (2007)

A multi-phase and a continuum based finite element model using the commercial finite element package ABAQUS is developed for simulating the orthogonal machining of composite materials. The materials considered for this study are a glass fiber reinforced epoxy composite and a ceramic matrix composite. The effect of varying the fiber orientation and tool rake angle on the cutting force, temperature distribution and damage during machining are considered. In the multi-phase approach the fiber and matrix are modeled as continuum elements with isotropic properties separated by an interfacial layer while the tool is modeled as a rigid body. The cohesive zone modeling approach is used for the interfacial layer. Bulk deformation and shear failure is considered in the fiber and matrix while the traction separation in the cohesive zone is used to ascertain the extent of delamination below the work surface. For validation purposes simulation results of the multi-phase approach are compared with experimental measurements. Parametric studies are conducted utilizing the equivalent homogenous (EHM) material model. The EHM simplifies the composite material into an anisotropic but locally homogenous material. External heating effect on the workpiece is considered in the EHM model to include preliminary results on Laser Assisted Machining. The model is successful in predicting cutting forces, temperature distribution entry and exit damage with respect to the fiber orientation.
Altered density of glomerular binding sites for atrial natriuretic factor in bile duct-ligated rats with ascites† ‡ (1991)

The renal response to atrial natriuretic factor is blunted in cirrhosis with ascites. This might be due to alterations of renal receptors for atrial natriuretic factor. Therefore density and affinity of glomerular atrial natriuretic factor binding sites of bile duct-ligated rats with ascites (n = 10) and of sham-operated controls (n = 10) were determined. Glomerular atrial natriuretic factor binding sites were identified to be of the B-("biologically active") and C-("clearance") receptor type. Discrimination and quantitative determination of B and C receptors for atrial natriuretic factor were achieved by displacement experiments with atrial natriuretic factor(99-126) or des(18-22)atrial natriuretic factor(4-23), an analogue binding to C receptors only. Density of total glomerular atrial natriuretic factor binding sites was significantly increased in bile duct-ligated rats (3,518 +/- 864 vs. 1,648 +/- 358 fmol/mg protein; p less than 0.05). This was due to a significant increase of C-receptor density (3,460 +/- 866 vs. 1,486 +/- 363 fmol/mg protein; p less than 0.05), whereas density of B receptors was not significantly different in bile duct-ligated rats (58 +/- 11 vs. 162 +/- 63 fmol/mg protein). Affinity of atrial natriuretic factor to its glomerular binding sites did not differ significantly between both groups. These data suggest that an altered glomerular atrial natriuretic factor receptor density could be involved in the renal resistance to atrial natriuretic factor in cirrhosis with ascites.
Functional Adhesiveness of the CX3CL1 Chemokine Requires Its Aggregation (2008)

In its native form, the chemokine CX3CL1 is a firmly adhesive molecule promoting leukocyte adhesion and migration and hence involved, along with its unique receptor CX3CR1, in various inflammatory processes. Here we investigated the role of molecular aggregation in the CX3CL1 adhesiveness. Assays of bioluminescence resonance energy transfer (BRET) and homogeneous time-resolved fluorescence (HTRF) in transfected cell lines and in primary cells showed specific signals indicative of CX3CL1 clustering. Truncation experiments showed that the transmembrane domain played a central role in this aggregation. A chimera with mutations of the 12 central transmembrane domain residues had significantly reduced BRET signals and characteristics of a non-clustering molecule. This mutant was weakly adhesive according to flow and dual pipette adhesion assays and was less glycosylated than CX3CL1, although, as we demonstrated, loss of glycosylation did not affect the CX3CL1 adhesive potency. We postulate that cell surfaces express CX3CL1 as a constitutive oligomer and that this oligomerization is essential for its adhesive potency. Inhibition of CX3CL1 self-assembly could limit the recruitment of CX3CR1-positive cells and may be a new pathway for anti-inflammatory therapies.
ChemInform Abstract: An Easy and Versatile Synthesis of Ureas from 2‐Benzylaminopyrimidine. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Gonadotropin Responses to Synthetic LRF: Dose-Response Relationship in Men (1973)

A dose-response relationship between circulating gonadotropin levels and synthetic LRF has been established in 10 adult males for iv doses ranging from 1–450 μg. Though both serum LH and FSH concentrations increased with dose, the responses in FSH were much smaller and occurred later than those of LH. A statistically significant increase in LH was observed in response to the 10 μg dose and the mean responses increased from 1 to 150 μg. In contrast, a statistically significant increase in FSH response was observed only at the 150 μg and 450 μg doses. Maximum serum levels were observed at a median time of 25 min following LRF administration for LH as compared to 45 min for FSH. The great variability in response among subjects (which was not related to age or body surface area) demonstrates the importance of serial studies in the same individuals.
Concurrent Hydrogenation of Aromatic and Nitro Groups over Carbon-Supported Ruthenium Catalysts (2014)

The concurrent hydrogenation of aromatic and nitro groups poses particular challenges due to the highly differing adsorption strengths of the two chemical moieties on the surfaces of metal catalysts. In a study of the hydrogenation of nitrobenzene as a model reaction, catalysts of ruthenium supported on carbon nanotubes (Ru/CNT) provided an ideal compromise, allowing for hydrogenation of both the aromatic ring and the nitro group. The use of methyl-labeled substrates enabled tracking the pathway of specific substrates and obtaining insight into the relative rates for the hydrogenation of nitrobenzene and intermediates. Together with findings on the coadsorption of nitrobenzene and aniline on the Ru/CNT catalyst, an advanced mechanistic model for the hydrogenation of nitrobenzene emerges.
Sodium Alignment in Clinical Practice—Implementation and Implications (2011)

Numerous reports in the general and the dialysis population have shown associations of sodium (Na(+)) intake, blood pressure, and survival. In addition to dietary Na(+) intake, positive Na(+) balance during dialysis needs to be considered as a source of Na(+). Dialysate Na(+) (DNa(+)) concentrations above the serum Na(+) concentration (SNa(+)) result in diffusive Na(+) flux from the dialysate into the patient, which has recently been reported to be associated with increased interdialytic weight gain and mortality. Individualization of the Na(+) prescription and Na(+) alignment (DNa(+) equal to SNa(+)) prevents positive Na(+) balance and improves patient outcomes. Alignment requires the knowledge of patients' SNa(+), which can be estimated from previous SNa(+) in the monthly routine laboratory measurements. Na(+) alignment was recently implemented in a dialysis clinic of Renal Research Institute. Preliminary results of this initiative have shown a trend of predialysis weight and blood pressure reduction. Expansion of this initiative to all clinics of RRI is currently underway and as of April 2011, four additional clinics have been included. Additional research on adequate Na(+) alignment is needed to account for Gibbs-Donnan effects, differences in charge across the dialyzer membrane, and variability in measurement methods. Regular calibration of DNa(+) delivery by dialysis machines is necessary to ensure that the dialysis prescription is followed. How to provide dialysis to severely hyponatremic patients remains an open question. Finally, long-term studies of the effects of Na(+) restriction on hospitalization and mortality are required to demonstrate the benefits of aligning DNa(+) with SNa(+).
Reduced lateral leakage losses of TM-like modes in silicon-on-insulator ridge waveguides (2008)

We numerically investigate the lateral leakage loss behavior for TM-like modes in silicon-on-insulator ridge waveguides. In order to improve the leakage loss properties, we propose a novel ridge waveguide structure where a dimple is introduced at the ridge center. It is shown that the ridge waveguide with a dimple is both low loss and fabrication tolerant. This behavior is predicted by not only an accurate finite-element-based analysis but also a simple, phenomenological effective-index-based analysis.
Environmental effects and risk control of antibiotic resistance genes in the organic solid waste aerobic composting system: A review (2021)

Abstract Antibiotic resistance genes (ARGs) have been diffusely detected in several kinds of organic solid waste, such as livestock manure, sludge, antibiotic fermentation residues, and food waste, thus attracting great attention. Aerobic composting, which is an effective, harmless treatment method for organic solid waste to promote recycling, has been identified to also aid in ARG reduction. However, the effect of composting in removing ARGs from organic solid waste has recently become controversial. Thus, this article summarizes and reviews the research on ARGs in relation to composting in the past 5 years. ARGs in organic solid waste could spread in different environmental media, including soil and the atmosphere, which could widen environmental risks. However, the conventional composting technology had limited effect on ARGs removal from organic solid waste. Improved composting processes, such as hyperthermophilic temperature composting, could effectively remove ARGs, and the HGT of ARGs and the microbial communities are identified as vital influencing factors. Currently, during the composting process, ARGs were mainly affected by three response pathways, (I) “Microenvironment-ARGs”; (II) “Microenvironment-microorganisms-ARGs”; (III) “Microorganisms-horizontal gene transfer-ARGs”, respectively. Response pathway II had been studied the most which was believed that microbial community was an important factor affecting ARGs. In response pathway III, mainly believed that MGEs played an important role and paid less attention to eARGs. Further research on the role and impact of eARGs in ARGs may be considered in the future. It aims to provide support for further research on environmental risk control of ARGs in organic solid waste.
Supplementary Methods, Figures 1-6, Tables 1-4 from Merkel Cell Polyomavirus-Specific CD8<sup>+</sup> and CD4<sup>+</sup> T-cell Responses Identified in Merkel Cell Carcinomas and Blood (2023)

&lt;p&gt;PDF file - 1294KB&lt;/p&gt;
Illumination strategies to achieve effective indoor millimeter wave imaging for personnel screening applications (2005)

The ability of millimetre-waves (mm-wave) to penetrate obscurants, be they clothing, fog etc., enables unique imaging applications in areas such as security screening of personnel and landing aids for aircraft. When used in an outdoor application, the natural thermal contrast provided by cold sky reflections off of objects allow for direct imaging of a scene. Imaging at mm-wave frequencies in an indoor situation requires that a thermal contrast be generated in order to illuminate and detect objects of interest. In the case of a portal screening application the illumination needs to be provided over the imaged area in a uniform, omni-directional manner and at a sufficient level of contrast to achieve the desired signal to noise ratio at the sensor. The primary options are to generate this contrast by using active noise sources or to develop a passive thermally induced source of mm-wave energy. This paper describes the approaches taken to developing and implementing an indoor imaging configuration for a mm-wave camera that is to be used in people screening applications. The camera uses a patented mechanical scanning method to directly generate a raster frame image of portal dimensions. Imaging has been conducted at a range of frequencies with the main focus being on 94GHz operation. Experiences with both active and passive illumination schemes are described with conclusions on the merits or otherwise of each. The results of imaging trials demonstrate the potential for using mm-wave imaging in an indoor situation and example images illustrate the capability of the camera and the illumination methods when used for personnel screening.
Novel ringing suppression circuit to achieve higher data rates in a linear passive star CAN FD (2014)

As the number of electronic control units (ECUs) in an automobile steadily increases, the demand for achieving higher data rates and connecting even more ECUs to the Controller Area Network (CAN) also rises significantly. Recently, as a method to achieve higher data rates up to 10 Mbps without change in the existing CAN system, CAN FD (CAN with Flexible Data-rate) is suggested. However, it is difficult to establish a CAN FD communication under the conventional CAN network configuration which makes it necessary to limit network size because of shortening in the bit decision timing while the ringing convergence time is the same as in conventional CAN. In this paper, we pick up a typical network configuration where the number of ECUs which can be connected in a linear passive star is less than 4 ECUs when the data rate for the data phase is 2 Mbps. We develop evaluation boards each of which is equipped with a CAN transceiver embedding the ringing suppression circuit which we have proposed and a CAN FD controller. We apply them to CAN FD and show an effect on higher data rates up to 2 Mbps under the conventional network configuration connecting 8 ECUs.
Les oxirannes : une ouverture vers la synthese de molecules selectivement fluorees (1989)

La synthese de molecules fluorees presente un interet certain. De par ses proprietes, l'atome de fluor peut induire des modifications notables de la reactivite. Nous avons etudie l'ouverture d'oxirannes et d'oxetannes par des organo-lithiens fluorovinyliques en presence de trifluorure de bore afin d'obtenir des alcools homoallyliques fluores ainsi que leurs homologues superieurs. Dans un deuxieme temps, nous nous sommes interesses aux fluoro-silyloxirannes. Nous en decrivons la synthese ainsi que leur reactivite vis-a-vis des acides protiques forts et des nucleophiles (ion fluorure,. . . ). Ces fluoro-silyloxirannes en presence d'une quantite catalytique d'ion fluorure et d'un exces de derives carbonyles conduisent avec de bons rendements aux epoxyalcools fluores. Dans la derniere partie de ce travail, des alcools allyliques monofluores ont ete epoxydes par l'hydroperoxyde de tertiobutyle en presence d'une quantite catalytique de vo (acac)#2 ou de ti(oipr)#4. Cette epoxydation s'est revelee etre remarquablement diastereoselective en faveur du produit erythro. La diastereoselectivite observee lors d'une epoxydation par un peracide est a l'inverse de ce qui est connu en serie hydrogenee. Les alcool allyliques difluores ont ete epoxydes selon la methode de sharpless. Enfin, nous avons commence une etude de la reactivite de ces epoxyalcools mono et difluores vis-a-vis de divers nucleophiles. Ce travail nous a permis de decrire un grand nombre de nouveaux produits fluores
Erythrocyte survival is controlled by microRNA-142 (2016)

Hematopoietic-specific microRNA-142 is a critical regulator of various blood cell lineages, but its role in erythrocytes is unexplored. Herein, we characterize the impact of microRNA-142 on erythrocyte physiology and molecular cell biology, using a mouse loss-of-function allele. We report that microRNA-142 is required for maintaining the typical erythrocyte biconcave shape and structural resilience, for the normal metabolism of reactive oxygen species, and for overall lifespan. microRNA-142 further controls ACTIN filament homeostasis and membrane skeleton organization. The analyses presented reveal previously unappreciated functions of microRNA-142 and contribute to an emerging view of small RNAs as key players in erythropoiesis. Finally, the work herein demonstrates how a housekeeping network of cytoskeletal regulators can be reshaped by a single micro-RNA denominator in a cell type specific manner.
THE ULTRACAM STORY (2012)

Abstract. The UltraCam-project created a novel Large Format Digital Aerial Camera. It was inspired by the ISPRS Congress 2000 in Amsterdam. The search for a promising imaging idea succeeded in May 2001, defining a tiling approach with multiple lenses and multiple area CCD arrays to assemble a seamless and geometrically stable monolithic photogrammetric aerial large format image. First resources were spent on the project in September 2011. The initial UltraCam-D was announced and demonstrated in May 2003. By now the imaging principle has resulted in a 4th generation UltraCam Eagle, increasing the original swath width from 11,500 pixels to beyond 20,000. Inspired by the original imaging principle, alternatives have been investigated, and the UltraCam-G carries the swath width even further, namely to a frame image with nearly 30,000 pixels, however, with a modified tiling concept and optimized for orthophoto production. We explain the advent of digital aerial large format imaging and how it benefits from improvements in computing technology to cope with data flows at a rate of 3 Gigabits per second and a need to deal with Terabytes of imagery within a single aerial sortie. We also address the many benefits of a transition to a fully digital workflow with a paradigm shift away from minimizing a project's number of aerial photographs and towards maximizing the automation of photogrammetric workflows by means of high redundancy imaging strategies. The instant gratification from near-real-time aerial triangulations and dense image matching has led to a reassessment of the value of photogrammetric point clouds to successfully compete with direct point cloud measurements by LiDAR.
Stress-induced proteins in aortic smooth muscle cells and aorta of hypertensive rats (1990)

The current studies were performed to determine whether vascular smooth muscle cells produce stress-induced proteins when subjected to experimental hypertension. Two-dimensional gel electrophoresis was used to analyze labeled proteins in cultured cells in response to either heat shock or arsenite treatment. The major heat shock proteins (HSPs) induced had molecular masses of 70, 90, and 110 kDa. Arsenite treatment produced a similar response with the additional induction of a 30-kDa protein. In vitro translations of total RNA from heat-shocked cells, and RNA blot hybridization using HSP 70 cDNA suggested that HSP 70 induction was transcriptionally regulated. Treatment of cells with norepinephrine or angiotensin II induced cellular hypertrophy without eliciting HSPs. In vitro translation of aortic RNA from rats rendered hypertensive by administration of deoxycorticosterone and a high salt intake also did not reveal HSP induction. The absence of HSP induction using an in vivo model of hypertension suggests that those proteins may not be required to mediate the vascular response to experimental hypertension.
Parathyroid hormone acts as a pharmacological chaperone on the parathyroid hormone receptor (2008)

Parathyroid hormone receptor (PTH1R) belongs to class B G‐protein‐coupled receptors and is the major regulator of extracellular calcium homeostasis. Binding of the native ligand parathyroid hormone (PTH) or biologically active peptide fragments of PTH to the receptor lead to the activation of Gs and Gq/G11 pathways with subsequent stimulation of adenylyl cyclase and phospholipase C. Activation of the PTH1R is followed by the recruitment of beta‐arrestin and subsequently to an efficient internalization of the receptor from the cell surface within several minutes. Here we show that long‐term stimulation of the PTH1R over several hours with PTH resulted in increased cellular protein levels and enhanced membrane distribution of the receptor. This increase of receptor levels was accompanied by an accumulation of high molecular mass moieties of the PTH1R. Analysis of the maturation steps during biosynthesis of the PTH1R revealed that the increased molecular mass was caused by a differential glycosylation pattern of the receptor. Blocking the export from the endoplasmic reticulum of the newly synthesized receptor by Brefeldin A completely inhibited the PTH induced mass changes. We therefore propose a ligand‐mediated stabilization of immature receptors in the endoplasmic reticulum which could eventually lead to a more efficient maturation of the PTH1R.