gebhart/patrepeval huggingface dataset:
Data from A2AR Adenosine Signaling Suppresses Natural Killer Cell Maturation in the Tumor Microenvironment (2023)

&lt;div&gt;Abstract&lt;p&gt;Extracellular adenosine is a key immunosuppressive metabolite that restricts activation of cytotoxic lymphocytes and impairs antitumor immune responses. Here, we show that engagement of A2A adenosine receptor (A2AR) acts as a checkpoint that limits the maturation of natural killer (NK) cells. Both global and NK-cell–specific conditional deletion of A2AR enhanced proportions of terminally mature NK cells at homeostasis, following reconstitution, and in the tumor microenvironment. Notably, A2AR-deficient, terminally mature NK cells retained proliferative capacity and exhibited heightened reconstitution in competitive transfer assays. Moreover, targeting A2AR specifically on NK cells also improved tumor control and delayed tumor initiation. Taken together, our results establish A2AR-mediated adenosine signaling as an intrinsic negative regulator of NK-cell maturation and antitumor immune responses. On the basis of these findings, we propose that administering A2AR antagonists concurrently with NK cell–based therapies may heighten therapeutic benefits by augmenting NK cell–mediated antitumor immunity.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Significance:&lt;/b&gt; Ablating adenosine signaling is found to promote natural killer cell maturation and antitumor immunity and reduce tumor growth. &lt;i&gt;Cancer Res; 78(4); 1003–16. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Pivotal role of CCL25 (TECK)-CCR9 in the formation of gut cryptopatches and consequent appearance of intestinal intraepithelial T lymphocytes (2002)

Cryptopatches (CP) are murine gut anatomical sites for generating thymus-independent intraepithelial T lymphocytes (IEL). However, it remains elusive how lympho-hematopoietic progenitor cells migrate from bone marrow (BM) into CP and differentiate into IEL. Here we show that mice reconstituted with BM-derived c-kit(+) cells express CCL25 (TECK)-intrakine gene, which reduces specifically the chemotactic response to CCL25 but not CXCL12 in the thymocytes. These mice exhibited a dramatic reduction of CP and IEL in the small intestine, and harbored conspicuously decreased numbers of c-kit(+) cells in the emaciated CP. In contrast, T cells in the thymic, splenic and lymph node compartments developed normally in these mice. Importantly, it was demonstrated that CD11c(+) dendritic stromal cells in CP expressed CCL25 and c-kit(+) Lin(-) BM cells displayed vigorous chemotactic response to CCL25. Furthermore, RT-PCR analysis detects mRNA expression of CCR9 in the c-kit(+) Lin(-) BM cells. Thus, these results demonstrate that the CCL25-CCR9 pathway is essential for CP formation and the consequent appearance of IEL.
Retracted: Modern probabilistic:model for massive data in e-learning (2018)

Since our collective information continues to be digitized and stored in several forms, web pages, scientific articles, books ... the task of finding information becomes more and more difficult. The need for new IT tools to organize and retrieve these vast amounts of information is growing day by day. Moreover, e-learning platforms are developing to meet the needs of learners. This article aims to use machine learning to determine actions that favor the learning process and the Latent Dirichlet Allocation (LDA) to discover the themes contained in the links proposed in a learning session. The aim to present a course which approaches the learner's attempts and which reduces the irrelevant propositions (Which is not appropriate to the need of the learner adult) goes through the modeling algorithms of the subjects.
AK106-001616, a Potent and Selective Inhibitor of Cytosolic Phospholipase A2: In Vivo Efficacy for Inflammation, Neuropathic Pain, and Pulmonary Fibrosis (2019)

3-[3-Amino-4-(indan-2-yloxy)-5-(1-methyl-1<i>H</i>-indazol-5-yl)-phenyl]-propionic acid (AK106-001616) is a novel, potent, and selective inhibitor of the cytosolic phospholipase A<sub>2</sub> (cPLA<sub>2</sub>) enzyme. Unlike traditional nonsteroidal anti-inflammatory drugs and selective cyclooxygenase-2 inhibitors, AK106-001616 reduced prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) and leukotriene B<sub>4</sub> (LTB<sub>4</sub>) production by stimulated cells. The suppression of PGE<sub>2</sub> and LTB<sub>4</sub> production was also confirmed using an air pouch model in rats administered a single oral dose of AK106-001616. AK106-001616 alleviated paw swelling in a rat adjuvant-induced arthritis (AIA) model. The maximum effect of the inhibitory effect of AK106-001616 was comparable with that of naproxen on paw swelling in a rat AIA model. Meanwhile, the inhibitory effect of AK106-001616 was more effective than that of naproxen in the mouse collagen antibody-induced arthritis model with leukotrienes contributing to the pathogenesis. AK106-001616 dose dependently reversed the decrease in paw withdrawal threshold not only in rat carrageenan-induced hyperalgesia, but also in a rat neuropathic pain model induced by sciatic nerve chronic constriction injury (CCI). However, naproxen and celecoxib did not reverse the decrease in the paw withdrawal threshold in the CCI model. Furthermore, AK106-001616 reduced the disease score of bleomycin-induced lung fibrosis in rats. In addition, AK106-001616 did not enhance aspirin-induced gastric damage in fasted rats, increase blood pressure, or increase the thromboxane A<sub>2</sub>/ prostaglandin I<sub>2</sub> ratio that is thought to be an underlying mechanism of thrombotic cardiovascular events increased by selective cyclooxygenase-2 inhibitors. Taken together, these data demonstrate that oral AK106-001616 may provide valuable effects for wide indications without attendant gastrointestinal and cardiovascular risks.
E01 Study on cutting of tantalum materials with binder-less diamond tools (2012)

Highly-biocompatible tantalum alloy is promising material for artificial joints to replace the commonly used Co-Cr alloy. There is however a productivity problem in using tantalum alloy material, since the material often inflicts serious damage on processing tools and shortens their life span. Diamond is considered to be the most appropriate tool material for use against tantalum alloys as it is highly abrasion-resistant, although it does lack stability. In this research, we conducted a cutting experiment using a nano-polycrystalline diamond tool, which has high mechanical strength, high-temperature hardness and high thermal conductance, to study the abrasion resistance characteristics of the tool.
Many-body theory versus simulations for the pseudogap in the Hubbard model (2000)

The opening of a critical-fluctuation-induced pseudogap (or precursor pseudogap) in the one-particle spectral weight of the half-filled two-dimensional Hubbard model is discussed. This pseudogap, appearing in our Monte Carlo simulations, may be obtained from many-body techniques that use Green functions and vertex corrections that are at the same level of approximation. Self-consistent theories of the Eliashberg type (such as the fluctuation exchange approximation) use renormalized Green functions and bare vertices in a context where there is no Migdal theorem. They do not find the pseudogap, in quantitative and qualitative disagreement with simulations, suggesting these methods are inadequate for this problem. Differences between precursor pseudogaps and strong-coupling pseudogaps are also discussed.
Determination of Contact Resistivity by the Cox and Strack Method for Metal Contacts to Bulk Bismuth Antimony Telluride (2009)

We successfully demonstrate the application of the Cox and Strack (CS) technique for contact resistivity measurement of metal contacts to bulk bismuth antimony telluride. The transmission line method (TLM), typically used for thin films, gives inconsistent contact resistivity results for bulk thermoelectric (TE) materials. Using TLM we observed a variation in measured contact resistivity for the TE material thickness range of . In contrast, the CS method gives a variation over the same substrate thickness range. We propose that this variability difference is related to the direction of current flow in the bulk TE materials.
300 mm Multi Level Air Gap Integration for Edge Interconnect Technologies and Specific High Performance Applications (2008)

Air gaps were successfully integrated in a multi level metallization interconnect stack using 65 nm design rules on 300 mm wafers. The proposed approach allows a low cost integration of localized air cavities using a sacrificial material to solve via misalignment issues. Air gap integration is shown to be mechanically robust and presents excellent electrical results with high gains on RC delays. In addition, air gaps structures tested in electromigration pass the targeted lifetime criterion. This easily scalable approach can be seriously considered either in aggressive interconnect geometries or in specific applications of existing technologies for which high electrical performance is locally required.
Poster abstract: Cybermussels: A biological sensor network using freshwater mussels (2012)

We describe our ongoing work on designing an underwater sensor network for monitoring the ecosystem of the Mississippi river using freshwater mussels as biological sensors. One of the most extensive manifestations of anthropogenic mismanagement of nitrogen is eutrophication of the Gulf of Mexico. Our vision is to create a biosensor network of native freshwater mussels in the Mississippi river to monitor and model key components of the nitrogen cycle.
Organocopper-catalyzed living radical polymerization initiated with aromatic sulfonyl chlorides (2000)

The living radical polymerization of methyl methacrylate initiated from aromatic sulfonyl chlorides and catalyzed by the new catalytic systems CuSBu/bpy CuSPh/bpy and CuCCPh/bpy (bpy = 2,2′-bipyridine) is described. For a target degree of polymerization of 200, lowering the ratio of catalyst to sulfonyl chloride group from 1/1 to 0.25/1 mol/mol decreases the values of the experimental rate constant of polymerization from 5.12 × 10−2, 2.4 × 10−2, and 1.87 × 10−2 min−1 to 1.8 × 10−3, 4.9 × 10−3, and 4.2 × 10−3 min−1 for CuSBu, CuSPh, and CuCCPh, respectively, whereas the corresponding initiator efficiency increases from 62 to 99%. The external orders of reaction in the catalyst are 0.79 for CuSPh, 0.88 for CuCCPh, and 1.64 for CuSBu. A mechanistic interpretation that involves the in situ generation of, most likely, the real catalyst CuCl, starting from combinations of CuSBu, CuSPh, and CuCCPh and sulfonyl chloride or alkyl halide growing species, is suggested. © 2000 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 38: 4353–4361, 2000
User-Optimizer Communication using Abstract Plans in Sybase ASE (2001)

Query optimizers are error prone, due to both their nature and the increased search space that modern query processing requires them to manage. This paper introduces the Sybase Plan (AP) language, a novel technology that puts together a set of proven techniques to palliate optimizer mistaken decisions. The AP language is a 2-way user-optimizer communication mechanism based on a physical level relational algebra. AP expressions are used both by the optimizer to describe the plan that it selected and by the user to direct the optimizer choices. APs are not textually part of the query. They are persistent objects stored in the system catalogs. APs yield important performance gains by eliminating all optimizer errors. 1.
A Particle Consistent with the Higgs Boson Observed with the ATLAS Detector at the Large Hadron Collider (2012)

Nearly 50 years ago, theoretical physicists proposed that a field permeates the universe and gives energy to the vacuum. This field was required to explain why some, but not all, fundamental particles have mass. Numerous precision measurements during recent decades have provided indirect support for the existence of this field, but one crucial prediction of this theory has remained unconfirmed despite 30 years of experimental searches: the existence of a massive particle, the standard model Higgs boson. The ATLAS experiment at the Large Hadron Collider at CERN has now observed the production of a new particle with a mass of 126 giga-electron volts and decay signatures consistent with those expected for the Higgs particle. This result is strong support for the standard model of particle physics, including the presence of this vacuum field. The existence and properties of the newly discovered particle may also have consequences beyond the standard model itself.
Origin of aromatase inhibitory activity via proteochemometric modeling (2015)

Aromatase, which is a rate-limiting enzyme that catalyzes the conversion of androgen to estrogen, plays an essential role in the development of estrogen-dependent breast cancer. Side effects due to aromatase inhibitors (AIs) necessitate the pursuit of novel inhibitor candidates with high selectivity, lower toxicity and increased potency. Designing a novel therapeutic agent against aromatase could be achieved computationally by means of ligand-based and structure-based methods. For over a decade, we have utilized both approaches to design potential AIs for which quantitative structure-activity relationship and molecular docking were used to explore inhibitory mechanisms of AIs towards aromatase. However, such approaches do not consider the effects that aromatase variants have on different AIs. In this study, proteochemometrics modeling was applied to analyze the interaction space between AIs and aromatase variants as a function of their substructural and amino acid features. Good predictive performance was achieved, as rigorously verified by 10-fold cross-validation, external validation, leave-one-compound-out cross-validation, leave-one-protein-out cross-validation and Y-scrambling tests. The investigations presented herein provide important insights into the mechanisms of aromatase inhibitory activity that could aid in the design of novel potent AIs as breast cancer therapeutic agents.
ACTIVE RC FILTERS USING OPERATIONAL TRANSRESISTANCE AMPLIFIERS (1998)

A new generalized universal filter configuration using the Operational Transresistance Amplifier is proposed. Twelve different filter circuits are derived from the general configuration. The circuits are designed to provide Low-pass, Band-pass, High-pass, All-pass and Notch responses through appropriate choice of admittances. The feasibility of this configuration in operating at high frequencies is presented. A detailed analysis taking the effect of the finite transresistance gain into consideration is presented. Self-compensation that requires no additional elements of some of the proposed filters is presented. The effectiveness of the proposed configuration is demonstrated by HSpice simulations.
Cell-Based Meniscal Repair Using an Aligned Bioactive Nanofibrous Sheath (2016)

Abstract : The goal of this proposal is to develop a novel bio-activated, aligned, nanofibrous scaffold that will serve as mechanical and biological support for the repair of radial tears of the meniscus. The hypothesis is that scaffolds consisting of aligned polymeric fibers, which structurally and mechanically mimic tendon and fibrocartilage, may be applied as a patch in alignment with the fibers of the tissue to be repaired, i.e., the meniscus with radial tear, to strengthen mechanically the surgical meniscal repair, and to subsequently guide tissue regeneration, for example, by seeded tissue progenitor cells. To achieve this objective, the first step is to develop an aligned nanofibrous scaffold (NFS) that meets the mechanical requirements of the native meniscal matrix and provides suture retention. This will be done by combining nanofibers composed of FDA-approved biodegradable polymers to produce a biocompatible scaffold, which will provide mechanical support to the healing meniscus. To support suture retention, a second layer of non-aligned fibers will be coated onto the aligned fibers. Secondly, the NFS will be bio-enhanced by impregnation with an extract derived from decellularized meniscus matrix, which contains molecules and growth factors specific to this tissue, to increase the formation of fibrocartilage by adult stem cells seeded within the scaffold. This bio-activation should enhance the biological integration, i.e. adhesion, and tissue regenerating activity of the NFS in meniscus repair. Finally, we will test the ability of the bio-activated, aligned NFS sheath to enhance meniscus repair when combined with stem cell-based wound bonding strategies and standard suture repair using an in vitro model of meniscal repair (employed to elucidate the optimal combination of materials developed here) and in vivo, repairing surgically-induced radial defects in a goat.
Psychedelikagestützte Psychotherapie in der Behandlung depressiver Störungen (2023)

ZUSAMMENFASSUNG In den letzten Jahren wurde ein Anstieg depressiver Erkrankungen innerhalb der deutschen Bevölkerung verzeichnet 1. Dabei sprechen ca. 30 % der Patienten nicht ausreichend auf die Behandlung mit verschiedenen Antidepressiva an und gelten somit als therapieresistent 2. Psychedelika wie Psilocybin stellen einen vielversprechenden Therapieansatz in der Behandlung der Depression dar. Der Einsatz von Psychedelika in Therapie und Forschung wurde Anfang der 1970er-Jahre durch die Eingruppierung als Betäubungsmittel stark erschwert und ist erst in den 1990er-Jahren wieder aufgenommen worden. In diesem Artikel wird der Stand der Forschung zur psychedelikaassistierten Psychotherapie vorgestellt. Ein besonderes Augenmerk wird dabei auf die Forschung zu psychedelikagestützter Psychotherapie bei depressiven Störungen gelegt, gefolgt von einem Ausblick.
An Insight into the Roles of MicroRNAs and Exosomes in Sarcoma (2019)

Sarcomas are rare solid tumors, but at least one-third of patients with sarcoma die from tumor-related disease. MicroRNA (miRNA) is a noncoding RNA that regulates gene expression in all cells and plays a key role in the progression of cancers. Recently, it was identified that miRNAs are transferred between cells by enclosure in extracellular vesicles, especially exosomes. The exosome is a 100 nm-sized membraned vesicle that is secreted by many kinds of cells and contains miRNA, mRNA, DNA, and proteins. Cancer uses exosomes to influence not only the tumor microenvironment but also the distant organ to create a premetastatic niche. The progression of sarcoma is also regulated by miRNAs and exosomes. These miRNAs and exosomes can be targeted as biomarkers and treatments. In this review, we summarize the studies of miRNA and exosomes in sarcoma.
Vision-Based Fuzzy 2D Motion Control of a Model Helicopter (2006)

In this paper the 2D motion of a model helicopter is studied. The position control of a 2D model helicopter falls into complex nonlinear problems domain which makes it rather hard. In this paper a fuzzy controller is proposed to stabilize the helicopter on a designated target. The 3D model of the helicopter is simplified to derive a 2D model and all the states are assumed to be measurable. Based on the model, it was possible to decouple the position and orientation control of the helicopter. However the two parts are related through a fuzzy rule base. To verify the proposed method a simulation program is written in C++ which takes advantages of OpenGL to enable having 3D features. The response graphs are then presented
Interactions of Conformationally Biased North and South 2‘-Fluoro-2‘,3‘-dideoxynucleoside 5‘-Triphosphates with the Active Site of HIV-1 Reverse Transcriptase (2000)

Molecular dynamics simulations of a ternary complex of HIV-1 reverse transcriptase (RT), double-stranded DNA, and bound dideoxynucleoside-5'-triphosphate (RT-DNA-ddNTP), utilizing the ddNTPs ddATP, betaFddATP, and alphaFddATP, explain the experimentally observed order of potency of these 5'-triphosphates as inhibitors of RT: ddATP > betaFddATP > alphaFddATP. On the basis of RT's known preference to bind the incoming dNTP (or ddNTP) with a north conformation at the polymerase site, alphaFddATP, which in solution prefers almost exclusively a north conformation, was predicted to be the most potent inhibitor. However, Tyr115, which appears to function as a steric gate to preclude the binding of ribonucleoside 5'-triphosphates, prevents the effective binding of alphaFddATP in its preferred north conformation. The south-biased betaFddATP, while able to bind to RT without hindrance by Tyr115, has to pay a high energy penalty to be flipped to the active north conformation at the polymerase site. Finally, the more flexible and less conformationally biased ddATP is able to switch to a north conformation at the RT site with a smaller energy penalty than betaFddATP. These results highlight the opposite conformational preferences of HIV-1 RT for alphaFddATP and betaFddATP and help establish conformational guidelines for optimal binding at the polymerase site of this enzyme.
Tribochemical Polymerization of Adsorbed n-Pentanol on SiO2 during Rubbing: When Does It Occur and Is It Responsible for Effective Vapor Phase Lubrication? (2010)

The origin and role of tribochemical reaction products formed while sliding silicon oxide surfaces in the presence of adsorbed alcohol molecules in equilibrium with the vapor phase were studied. Wear and friction coefficient studies with varying contact loads and n-pentanol vapor environments were used to determine under what operating conditions the tribochemical reaction species was produced. Imaging time-of-flight secondary ion mass spectrometry and microinfrared spectroscopy found that hydrocarbon species with a molecular weight higher than the starting vapor molecules are produced when there is wear of the SiO(2) surface. When the n-pentanol vapor lubrication is effective and the silicon oxide surface does not wear, then the tribochemical polymerization products are negligible. These results imply that the tribochemical polymerization is associated with the substrate wear process occurring due to insufficient adsorbate supply or high mechanical load. The tribochemical reactions do not seem to be the primary lubrication mechanism for vapor phase lubrication of SiO(2) surfaces with alcohol, although they may lubricate the substrate momentarily upon failure of the alcohol vapor delivery to the sliding contact.