gebhart/patrepeval huggingface dataset:
Stereochemical aspects of phosphorus‐containing cyclohexanes (1979)

This chapter contains sections titled: Introduction Applications of NMR Spectroscopy Structure, Conformation, and Stereochemistry of Cyclohexane Rings Containing Tetracoordinate Phosphorus Structure, Conformation, and Stereochemistry of Cyclohexane Rings Containing Tetracoordinate Phosphorus Stereochemistry of Compounds with Cyclohexane Rings Containing Pentacoordinate Phosphorus Overview
Data-Driven Respiratory SPECT-Gating for Determination of Liver-Lung-Shunt Fraction (2021)

Ziel/Aim In hepatic radio-embolization, lungs are at risk of substantial radiation damage. For assessing its probability, each patient undergoes pre-therapeutic imaging with, e.g., Tc-99m-macro-aggregated albumin (MAA) in order to determine the liver-lung-shunt fraction (LLSF).
Partial nephrectomy is not associated with an overall survival advantage over radical nephrectomy in elderly patients with stage Ib‐II renal masses: An analysis of the national cancer data base (2018)

Receipt of PN is associated with improved OS in patients with T1a RCC. No procedure-related differences in OS were observed for patients age ≥75 years who had tumors measuring >4 cm. Decisions to undergo PN for T1b/T2 tumors should be based on individualized risk assessment.
Immune responses to HIV and SIV in mucosal tissues: ‘location, location, location’ (2010)

Mucosal tissues serve as the major portal of entry for HIV, and house a majority of the body's lymphocytes, including CD4 T-cells that are targets for infection. Recent studies have focused renewed attention on events occurring immediately after transmission, and underscore the concept that the balance between inflammation and protective immunity is established by host responses in mucosal tissues.
Supplementary Figure 2 from The TGFβ–miR200–MIG6 Pathway Orchestrates the EMT-Associated Kinase Switch That Induces Resistance to EGFR Inhibitors (2023)

&lt;p&gt;PDF file - 108KB, TGFbeta induces EMT-associated kinase switch promotes erlotinib-resistance of tumor cells. A. Erlotinib sensitive cell lines H292 and SCC-S were treated with TGFβ1 (4 ng/ml) for 21 days and immunoblot analysis was performed with indicated antibodies. B. Parental and TGFbeta-induced H358 and SCC-S cells were treated with erlotinib for 72 hours and cell viability was assayed. Values were set at 100% for untreated controls. C. Protein lysates were extracted from H358 and SCC-S cells treated or untreated with TGFbeta for 21 days and immunoblot analysis was performed with antibodies against indicated phospho RTKs. Beta-actin was used as a loading control.&lt;/p&gt;
Ferroelectric bismuth titanate/superconductor (Y-Ba-Cu-O) thin-film heterostructures on silicon (1991)

The growth by pulsed-laser deposition of c-axis-oriented bismuth titanate (BTO)/YBa2Cu3O7(YBCO) superconductor heterostructures on [001]-oriented Si with epitaxial yttria-stabilized ZrO2 as a buffer layer is reported. X-ray-diffraction studies of the heterostructures show that all the layers grow in the c-axis orientation, with a rocking angle of 1.0°–1.2° for the bismuth titanate layer and 0.6°–0.8° for the YBCO layer. Rutherford backscattering ion channeling yields of 28% at the surface have been obtained. Transmission electron microscopy of cross-sectioned samples reveal that the BTO layer has a significant density of translational boundaries that propagate at 45° to the film surface. The BTO film exhibits ferroelectric hysteresis and a dielectric constant in the range of 180–200.
Highly Flexible, Electrically Driven, Top-Emitting, Quantum Dot Light-Emitting Stickers (2014)

Flexible information displays are key elements in future optoelectronic devices. Quantum dot light-emitting diodes (QLEDs) with advantages in color quality, stability, and cost-effectiveness are emerging as a candidate for single-material, full color light sources. Despite the recent advances in QLED technology, making high-performance flexible QLEDs still remains a big challenge due to limited choices of proper materials and device architectures as well as poor mechanical stability. Here, we show highly efficient, large-area QLED tapes emitting in red, green, and blue (RGB) colors with top-emitting design and polyimide tapes as flexible substrates. The brightness and quantum efficiency are 20,000 cd/m(2) and 4.03%, respectively, the highest values reported for flexible QLEDs. Besides the excellent electroluminescence performance, these QLED films are highly flexible and mechanically robust to use as electrically driven light-emitting stickers by placing on or removing from any curved surface, facilitating versatile LED applications. Our QLED tapes present a step toward practical quantum dot based platforms for high-performance flexible displays and solid-state lighting.
Fundamental study on reducing on-resistance by introducing strain into silicon vertical power devices (2019)

In this paper, we examine the feasibility of reducing the on-resistance by introducing strain into the drift layer of Si vertical power devices. The strain effect on the resistance to vertical conduction in the n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-</sup> -Si layer was evaluated using a four-point bending method. The experimental data correspond well with the theoretical values calculated using the piezoresistive coefficient. These results indicate that strain management is a promising method for reducing the on-resistance of Si vertical power devices.
<title>Limitations Of Opto-Electronic Neural Networks</title> (1989)

Neural networks are composed of three components: neurons, weights, and connections. Limitation on implementing these components in electronics and optics are discussed. We show that using electronically fabricated neurons and a combination of optics and electronics for the weights and connections efficiently utilizes the advantage of each technology. The choice of the technology used to implement the weights and connections depends on the type of neural network being built.
Distinct patterns of transcriptional and epigenetic alterations characterize acute and chronic kidney injury (2018)

Acute kidney injury (AKI) and chronic kidney disease (CKD) are considered early and late phases of a pathologic continuum of interconnected disease states. Although changes in gene expression patterns have recently been elucidated for the transition of AKI to CKD, the epigenetic regulation of key kidney injury related genes remains poorly understood. We used multiplex RT-qPCR, ChIP-qPCR and integrative analysis to compare transcriptional and epigenetic changes at renal disease-associated genes across mouse AKI and CKD models. These studies showed that: (i) there are subsets of genes with distinct transcriptional and epigenetically profiles shared by AKI and CKD but also subsets that are specific to either the early or late stages of renal injury; (ii) differences in expression of a small number of genes is sufficient to distinguish AKI from CKD; (iii) transcription plays a key role in the upregulation of both AKI and CKD genes while post-transcriptional regulation appears to play a more significant role in decreased expression of both AKI and CKD genes; and (iv) subsets of transcriptionally upregulated genes share epigenetic similarities while downregulated genes do not. Collectively, our study suggests that identified common transcriptional and epigenetic profiles of kidney injury loci could be exploited for therapeutic targeting in AKI and CKD.
Neural control of the lower urinary and gastrointestinal tracts: Supraspinal CNS mechanisms (2009)

Normal urinary function is contingent upon a complex hierarchy of CNS regulation. Lower urinary tract afferents synapse in the dorsal horn of the spinal cord and ascend to the midbrain periaqueductal gray (PAG), with a separate nociception path to the thalamus. A spino-thalamo-cortical sensory pathway is present in some primates, including humans. In the brainstem, the pontine micturition center (PMC) is a convergence point of multiple influences, representing a co-ordinating center for voiding. Many PMC neurones have characteristics necessary to categorize the center as a pre-motor micturition nucleus. In the lateral pontine brainstem, a separate region has some characteristics to suggest a "continence center." Cerebral control determines that voiding is permitted if necessary, socially acceptable and in a safe setting. The frontal cortex is crucial for decision making in an emotional and social context. The anterior cingulate gyrus and insula co-ordinate processes of autonomic arousal and visceral sensation. The influence of these centers on the PMC is primarily mediated via the PAG, which also integrates bladder sensory information, thereby moderating voiding and storage of urine, and the transition between the two phases. The parabrachial nucleus in the pons is also important in behavioral motivation of waste evacuation. Lower urinary tract afferents can be modulated at multiple levels by corticolimbic centers, determining the interoception of physiological condition and the consequent emotional motor responses. Alterations in cognitive modulation, descending modulation, and hypervigilance are important in functional (symptom-based) clinical disorders.
Topical Minocycline Foam for the Treatment of Impetigo in Children: Results of a Randomized, Double-Blind, Phase 2 Study. (2016)

Topical minocycline foam may be a safe and effective new treatment option for impetigo in children, including those with MRSA. <br /><br /> <em>J Drugs Dermatol.</em> 2016;15(10):1238-1243.
Approximate Data Dependence Graph Generation Using Adaptive Sampling (2016)

Identifying data dependence among loop iterations is a fundamental step in the parallelisation process. Generally, code instrumentation provides for such information at the expense of high runtime performance penalty. This paper proposes an efficient method that trades slight accuracy reduction with significant performance gain to generate an approximate dependence graph. The proposed method relies on replicating the loop under test, providing for instrumented and not instrumented code versions, and adaptively switching between them, as well as deciding on the analysis detail, depending on the stability of measured dependence distances. Moreover, the method utilises random sampling, decreasing the chances of missing dependent irregular memory accesses. An initial performance investigation of the method is conducted using the Pin binary instrumentation tools, results on selected PolyBench kernels shows up to 8.5× improvement in instrumentation time, with no missed dependencies in 14 kernels, and 45% missed dependencies in one kernel.
Future Abradable Requirements Needed by Aerospace OEM’s and Their Material and Equipment Suppliers (2007)

The cost of in-service clearance control coating failure analysis can be high to the aerospace OEM’s (Original Equipment Manufacturers). The failure analysis process is labor-intensive and time-consuming. It is for these reasons that OEM’s will be requiring vendors of materials and equipment to have: (1) greater in-process controls on spray process equipment, (2) greater statistical process control (SPC) documentation of key material manufacturing process variables, (3) increased documentation of cause and effect of powder manufacturing and spray process variables and better understanding of the influence of these variables on overall performance, and (4) more detailed coating/powder specifications. This paper will discuss the future needs of aerospace OEM’s in these four areas and specifically discuss how vendors are addressing these needs.
EDITORIAL Aberrant Methylation of Gene Promoters in Cancer—Concepts, Misconcepts, and Promise (2000)

presence of abnormal methylation in the 5 � region of the deathassociated protein (DAP) gene in tumor DNA predicts shorter survival in patients who had undergone surgery for non-smallcell lung cancer (NSCLC). This change in methylation is an example of an epigenetic process that is attracting increasing attention, both because of its potential significance to our basic understanding of cancer and because of its possible use for improved cancer diagnosis and treatment. However, the study by Tang et al. also raises many of the questions that constitute an ongoing vigorous, but constructive, debate as to the true biologic significance of these postreplicative DNA changes (2). “CpG islands ” surround the transcription start regions of almost half of the genes in the human genome and are normally unmethylated. Hypermethylation of CpG islands in cancers is associated with transcriptional silencing of the genes in which
The Extended Mid-Infrared Structure of the Circinus Galaxy (2004)

We present subarcsecond resolution mid-IR images of the Circinus galaxy at 8.74 and 18.33 μm. We resolve extended emission at both wavelengths, extending ~2'' from each side of the nucleus in an approximate east-west direction. These extensions are spatially coincident with previously detected compact (~30 pc) V-shaped [O III] emission extending northwest of the nucleus as well as countercone [Si VI] emission, emission at these wavelengths interpreted as delineating the interface between inflowing material and the ionization cone. We detect no extended mid-IR emission associated with the structure responsible for collimating the ionizing photons (i.e., obscuring torus or disk of material), limiting the flux density of the obscuring structure to ≤0.27 mJy or a diameter of ≤020 (≤4 pc).
Anoxia/reoxygenation-induced neutrophil adherence to cultured endothelial cells (1992)

Previous studies have shown enhanced neutrophil adhesion to endothelial cells exposed to anoxia and then reoxygenated (A/R). To define the molecular basis for these observations, we evaluated the relative roles of CD11/CD18 determinants (CD11a and CD11b) of neurtrophils and the endothelial adhesion proteins intercellular adhesion molecule 1 (ICAM-1) and endothelial-leukocyte adhesion molecule 1 (ELAM-1). Human umbilical vein endothelial cell (HUVEC) monolayers were exposed to anoxia for 30 min, reoxygenated, and then reacted with 51Cr-labeled neutrophils in adhesion assays. Neutrophil adhesion to HUVEC exposed to A/R was significantly increased (2.7-fold) as compared with that observed with normoxic (control) HUVEC. This A/R-induced hyperadherence was significantly diminished by monoclonal antibodies (MAb) directed at CD11a, CD11b, CD18 or ICAM-1, but not by MAb directed at ELAM-1. The inhibitory effects of anti-CD11a and anti-CD11b were additive and equivalent to that of anti-CD18 MAb. A/R did not elicit increased levels of ICAM-1 or ELAM-1 mRNA or surface protein. However, immunofluorescence flow cytometry indicated that incubation of neutrophils in supernatants of A/R-conditioned HUVEC elicited an increase of surface CD11b and CD18, but not CD11a. Supernatants from A/R-conditioned HUVEC promoted neutrophil adherence to naive HUVEC, and this hyperadhesivity was diminished by a platelet-activating factor (PAF) receptor antagonist and catalase but not by a 5-lipoxygenase inhibitor, a leukotriene B4 receptor antagonist, or superoxide dismutase. These studies indicate that A/R promotes neutrophil adherence via CD11a/CD18- and CD11b/CD18-dependent interactions with ICAM-1 that appear to be mediated by hydrogen peroxide and PAF.
ChemInform Abstract: Simple and Condensed β‐Lactams. Part 19. Synthesis of Some New 7‐ Acylamino‐2‐iso‐oxacephem‐4‐carboxylic Acids. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Frailty and Cause-Specific Hospitalization Among Persons Aging With HIV Infection and Injection Drug Use (2016)

The frailty phenotype predicts vulnerability to chronic and infectious disease-related hospitalization. Frailty-targeted interventions may mitigate the substantial burden of infectious and chronic disease-related morbidity and health care utilization in HIV-infected and uninfected populations.
Controlled Photochemical Release of Nitric Oxide fromO2-Benzyl-Substituted Diazeniumdiolates (2002)

An investigation of potential photosensitive protecting groups for diazeniumdiolates (R2N-N(O)=NO-) has been initiated, and here the effect of meta electron-donating groups on the photochemistry of O2-benzyl-substituted diazeniumdiolates (R2N-N(O)=NOCH2Ar) is reported. Photolysis of the parent benzyl derivative (Ar = Ph) results almost exclusively in undesired photochemistry-the formation of nitrosamine and an oxynitrene intermediate with very little, if any, photorelease of the diazeniumdiolate. We have been able to use meta substitution to tune the photochemistry of these benzylic systems. The desired diazeniumdiolate photorelease has been shown to become more substantial with stronger pi-donating meta substituents. This effect has been verified by direct observation of the photoreleased diazeniumdiolate with 1H NMR spectroscopy and by NO quantification measurements conducted in high- and low-pH solutions. In addition, the observed rates of NO release are consistent with that expected for normal thermal decomposition of the diazeniumdiolate in aqueous solutions and also show the same pH dependence.
Aggregated Structures in Langmuir−Blodgett Films of Pyridinium−Dicyanomethanide Dyes (1997)

ADVERTISEMENT RETURN TO ISSUEPREVNoteAggregated Structures in Langmuir−Blodgett Films of Pyridinium−Dicyanomethanide DyesRiccardo Ricceri, Daniela Grando, Alessandro Abbotto, Antonio Facchetti, Giorgio A. Pagani, and Gabriella GabrielliView Author Information Dipartimento di Chimica, Universitá di Firenze, via G. Capponi 9, I-50121 Firenze, Italy, IROE-CNR, via Panciatichi, I-50100 Firenze, Italy, and Dipartimento di Scienza dei Materiali, Universitá degli Studi di Milano, via Emanueli 15, I-20126 Milano, Italy Cite this: Langmuir 1997, 13, 21, 5787–5790Publication Date (Web):October 15, 1997Publication History Received22 May 1997Revised21 July 1997Published online15 October 1997Published inissue 1 October 1997https://pubs.acs.org/doi/10.1021/la970530hhttps://doi.org/10.1021/la970530hbrief-reportACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views97Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Absorption,Crystal structure,Molecular structure,Molecules,Monomers Get e-Alerts
The Multidisciplinary Approach to Renal Denervation: Current Evidences and Open Questions (2014)

Renal denervation (RD) is a new clinical procedure which aims to treat resistant hypertensive patients. As with every new technology introduced into the clinical setting, many aspects were not explored sufficiently in order to be implemented into routine clinical practice. Advances in clinical technology require different steps of development, which start from preliminary in vitro experiments and finally arrive in the market, available for physicians when they have been proven to produce benefits for patients. Each stage usually takes many years before acquiring consensus from specialists involved in specific fields. In our opinion, this is a long and blind way and is a disadvantage to patients who need rapid, specific, and effective treatments. Otherwise, a multidisciplinary approach can provide the right evaluation of RD position and its potential for clinical application and research development. Therefore, we decided to draw a well-structured literature review from different specialists’ points of view in order to cover the subject in a translational manner. We reported animal models and experimental trials, in chronological order, and their evidences which have created the basis for human research. Technologies and devices were compared to underlined advantages and disadvantages. An update of clinical data was considered to define clinical needs in order to build focused trials. Furthermore, we evaluate the feasibility of routine RD clinical use by means of an economic analysis. Finally, we tried to settle the main unresolved questions and then assessed future RD perspectives, including non-hypertension indications.
Optical interconnection network with 3-D layout and distributed control (1990)

We present an optical, free-space, crossbar-like N x N interconnection network based on N routing switches of the form 1 to N. The network is used to connect Processing Elements (PEs) in a large-scale, parallel computer, utilizing a 3-D space layout. Each PE controls and sets its own switch, using a distributed algorithm. The switch deflects a monochromatic, coherent light beam towards one of N possible spots. This beam, carrying information from the sending PE, is thereafter passively deflected by a system of multifacet holograms, until it reaches the target PE. Unlike other schemes, this layout uniformly fills the 3-D space with PEs. Thus, inter-PE communication can be minimized when algorithms exploit locality of reference.
Near-Infrared Spectroscopy as a Tool for Marine Mammal Research and Care (2022)

Developments in wearable human medical and sports health trackers has offered new solutions to challenges encountered by eco-physiologists attempting to measure physiological attributes in freely moving animals. Near-infrared spectroscopy (NIRS) is one such solution that has potential as a powerful physio-logging tool to assess physiology in freely moving animals. NIRS is a non-invasive optics-based technology, that uses non-ionizing radiation to illuminate biological tissue and measures changes in oxygenated and deoxygenated hemoglobin concentrations inside tissues such as skin, muscle, and the brain. The overall footprint of the device is small enough to be deployed in wearable physio-logging devices. We show that changes in hemoglobin concentration can be recorded from bottlenose dolphins and gray seals with signal quality comparable to that achieved in human recordings. We further discuss functionality, benefits, and limitations of NIRS as a standard tool for animal care and wildlife tracking for the marine mammal research community.
Antimicrobial Compounds from Alnus Rubra (1995)

The methanol extract of the bark of Alnus rubra showed antimicrobial activity against Gram-positive and Gram-negative bacteria. Diarylheptanoid and its glycoside (oregonin) were identified as the two constituents responsible for this activity.