gebhart/patrepeval huggingface dataset:
Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment (2005)

The interactions of transformed cells with the surrounding stromal cells are of importance for tumor progression and metastasis. The relevance of adipocyte-derived factors to breast cancer cell survival and growth is well established. However, it remains unknown which specific adipocyte-derived factors are most critical in this process. Collagen VI is abundantly expressed in adipocytes. Collagen -/-mice in the background of the mouse mammary tumor virus/polyoma virus middle T oncogene (MMTV-PyMT) mammary cancer model demonstrate dramatically reduced rates of early hyperplasia and primary tumor growth. Collagen VI promotes its growthstimulatory and pro-survival effects in part by signaling through the NG2/chondroitin sulfate proteoglycan receptor expressed on the surface of malignant ductal epithelial cells to sequentially activate Akt and -catenin and stabilize cyclin D1. Levels of the carboxyterminal domain of collagen VI3, a proteolytic product of the fulllength molecule, are dramatically upregulated in murine and human breast cancer lesions. The same fragment exerts potent growth-stimulatory effects on MCF-7 cells in vitro. Therefore, adipocytes play a vital role in defining the ECM environment for normal and tumor-derived ductal epithelial cells and contribute significantly to tumor growth at early stages through secretion and processing of collagen VI.
Effects of spatial sampling and luminance quantization on the image quality of color matrix displays (1990)

Color matrix displays (CMD’s) constitute a new generation of high-resolution, two-dimensional sampled visual display devices. We describe a CMD image-simulation system and a series of psychophysical image-quality experiments to investigate basic visual parameters of sampled displays. For binary CMD’s, a RGBG pixel mosaic was found to produce imaging superior overall to that of the more-conventional RGB mosaics. For CMD’s with gray-scale capability, a discrete approximation of a Gaussian band-limiting line-spread function dramatically improved CMD image quality for all pixel mosaics. Across the six image colors tested, image quality for band-limited CMD images approached asymptotic levels at approximately 3000 pixels deg−2 and eight gray levels, regardless of the pixel mosaic. The results are interpreted within the context of contemporary views of human visual system channel structure and elucidate the role of applied-vision studies in advanced display systems design.
A proteomics-based approach identifies secreted protein acidic and rich in cysteine as a prognostic biomarker in malignant pleural mesothelioma (2016)

Low circulating SPARC was associated with favourable prognosis. Secreted protein acidic and rich in cysteine was present in both tumour cells and stromal fibroblasts; and our in vitro and in vivo experiments suggest that stromal fibroblasts are a potential source of circulating SPARC.
Radiographic Assessment of Interbody Fusion Using Recombinant Human Bone Morphogenetic Protein Type 2 (2003)

The use of rhBMP-2 is a promising method for facilitating anterior intervertebral spinal fusion in patients who have undergone anterior lumbar fusion surgery.
Aberrant V(D)J Recombination in Ataxia Telangiectasia Mutated-Deficient Lymphocytes Is Dependent on Nonhomologous DNA End Joining (2008)

During lymphocyte Ag receptor gene assembly, DNA cleavage by the Rag proteins generates pairs of coding and signal ends that are normally joined into coding joints and signal joints, respectively, by the classical nonhomologous end-joining (NHEJ) pathway of DNA double strand break repair. Coding and signal ends can also be aberrantly joined to each other, generating hybrid joints, through NHEJ or through NHEJ-independent pathways, such as Rag-mediated transposition. Hybrid joints do not participate in the formation of functional Ag receptor genes and can alter the configuration of Ag receptor loci in ways that limit subsequent productive rearrangements. The formation of these nonfunctional hybrid joints occurs rarely in wild type lymphocytes, demonstrating that mechanisms exist to limit both the NHEJ-dependent and the NHEJ-independent joining of a signal end to a coding end. In contrast to wild-type cells, hybrid joint formation occurs at high levels in ataxia telangiectasia mutated (Atm)-deficient lymphocytes, suggesting that Atm functions to limit the formation of these aberrant joints. In this study, we show that hybrid joint formation in Atm-deficient cells requires the NHEJ proteins Artemis, DNA-PKcs, and Ku70, demonstrating that Atm functions primarily by modulating the NHEJ-dependent, and not the NHEJ-independent, joining of coding ends to signal ends.
LeadLine: Interactive visual analysis of text data through event identification and exploration (2012)

Text data such as online news and microblogs bear valuable insights regarding important events and responses to such events. Events are inherently temporal, evolving over time. Existing visual text analysis systems have provided temporal views of changes based on topical themes extracted from text data. But few have associated topical themes with events that cause the changes. In this paper, we propose an interactive visual analytics system, LeadLine, to automatically identify meaningful events in news and social media data and support exploration of the events. To characterize events, LeadLine integrates topic modeling, event detection, and named entity recognition techniques to automatically extract information regarding the investigative 4 Ws: who, what, when, and where for each event. To further support analysis of the text corpora through events, LeadLine allows users to interactively examine meaningful events using the 4 Ws to develop an understanding of how and why. Through representing large-scale text corpora in the form of meaningful events, LeadLine provides a concise summary of the corpora. LeadLine also supports the construction of simple narratives through the exploration of events. To demonstrate the efficacy of LeadLine in identifying events and supporting exploration, two case studies were conducted using news and social media data.
Enzymatic Upgrading of Heavy Crudes via Partial Oxidation or Conversion of PAHs (2002)

The objective of this program was to investigate new enzyme-based technologies for upgrading of heavy oils. Enzymes were selected for screening from those capable of conversion of polyaromatic hydrocarbons (PAHs) reported in the literature. Oxidative reactions of PAHs using hydrogen peroxide as an oxidant with conversion to partially oxidized products were used. The enzymes (lignin peroxidase, cytochrome c) were tested in various organic solvents and found to loose activity in pure organic solvents. A thermodynamic analysis revealed lack of effective interaction between the substrate and enzyme as the cause for low activity. The protein cytochrome c was modified to work in organic media by chemical hydrophobic group attachment. Two different modifications were made: attachment of polyethylene glycol (PEG) and alkyl groups. Alkyl groups, being small could be attached at interior locations within the core of the enzyme and possibly near the active site. Increase in the threshold solvent concentration where maximum enzyme activity occurred indicated potential of this strategy for effective enzyme-substrate interaction. Further improvements in enzyme activity called for other diverse methods due to the unavailability of sufficient chemical modification sites. Genetic techniques were therefore explored for further improvements. These experiments focused on cloning of a gene for the fungal enzyme lignin peroxidase (lip) into yeast Pichia pastoris, which would allow easy manipulation of the gene. However, differences in the fungal and yeast cellular machinery impeded significant expression of the fungal enzyme. Several strategies were explored to allow higher-level expression of the enzyme, which was required for enzyme improvement. The strategies used in this investigation are described in the report. Industrial in-kind support was available throughout the project period. review of the research results was carried out on a regular basis (bimonthly reports and annual meetings) followed by suggestions for improvement in ongoing work and direction for future work. A significant portion of the industrial support was in the form of technical consultation and expert advice via meetings and phone conversations.
Sterically shielded diboron-containing metallocene olefin polymerization catalysts (2023)

A non-coordinating anion, preferably containing a sterically shielded diboron hydride, if combined with a cyclopenta-dienyl-substituted metallocene cation component, such as a zirconocene metallocene, is a useful olefin polymerization catalyst component. The anion preferably has the formula ##STR1## where R is branched lower alkyl, such as t-butyl.
Explorations of Wrist Haptic Feedback for AR/VR Interactions with Tasbi (2020)

Most widespread haptic feedback devices for augmented and virtual reality (AR/VR) fall into one of two categories: simple hand-held controllers with a single vibration actuator, or complex glove systems with several embedded actuators. In this work, we explore haptic feedback on the wrist for interacting with virtual objects. We use Tasbi, a compact bracelet device capable of rendering complex multisensory squeeze and vibrotactile feedback. Leveraging Tasbi's haptic rendering, and using standard visual and audio rendering of a head mounted display, we present several interactions that tightly integrate sensory substitutive haptics with visual and audio cues. Interactions include push/pull buttons, rotary knobs, textures, rigid body weight and inertia, and several custom bimanual manipulations such as shooting an arrow from a bow. These demonstrations suggest that wrist-based haptic feedback substantially improves virtual hand-based interactions in AR/VR compared to no haptic feedback.
Direct transmission protection in IEEE 802.11 networks (2008)

In this paper, we discuss some problems related to direct transmissions between QSTAs in an infrastructure 802.11 WLAN with a legacy access point (AP). In the infrastructure mode, collisions of data frames caused by hidden terminals interference can be avoided by the RTS/CTS exchange anticipating the data frames, if and only if all data communications between stations are performed via the AP. The interference problem is solved because all terminals are within the transmission range (TX range) of the AP. However, the RTS/CTS exchange is not enough to protect direct transmissions between QSTAs. In this paper, we analyze the state-of-the-art direct transmissions protection approaches, show their limitations, propose and simulate our own protection schemes.
ChemInform Abstract: Sequence Dependence of Secondary‐Structure Formation. Part 4. Helix‐Forming Potential of Amphiphilic Oligopeptides Containing Aib Residues. (1986)

Abstract The conformational properties of Aib‐containing Oligopeptides with the propensity to adopt amphiphilic helical conformations were investigated by CD spectroscopy in solution.
Cascade Sliding Mode &#x2014; New Robust PID contro for BLDC motor of In-wheel system (2011)

A torque control method for Brushless Direct Current (BLDC) motor is introduced in this paper, which plays vital roles in In-wheel vehicle system. In-wheel motor can be used in electric cars with 4 wheels independent drive configuration. Within every wheel, there can be one “Direct-Drive In-wheel motor” to generate the necessary torque per wheel. In order to improve dynamic response characteristics in terms of torque and disturbance reject, a cascade Sliding Mode Control - New Robust PID (SMC - NRPID) controller is developed. The structure of NRPID is composed with new type of integral control action. This new improved integral control has concept of error window and weight function concept. The performance of NRPID technique is compared with those of conventional ones via simulation. Simulation results show that the proposed method is effective and enhanced the dynamic performance of the system.
ChemInform Abstract: Iron‐Catalyzed Cross‐Coupling Reactions of Alkyl‐Grignard Reagents with Aryl Chlorides, Tosylates, and Triflates. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A dentin-derived hydrogel bioink for 3D bioprinting of cell laden scaffolds for regenerative dentistry (2017)

Recent studies in tissue engineering have adopted extracellular matrix (ECM) derived scaffolds as natural and cytocompatible microenvironments for tissue regeneration. The dentin matrix, specifically, has been shown to be associated with a host of soluble and insoluble signaling molecules that can promote odontogenesis. Here, we have developed a novel bioink, blending printable alginate (3% w/v) hydrogels with the soluble and insoluble fractions of the dentin matrix. We have optimized the printing parameters and the concentrations of the individual components of the bioink for print accuracy, cell viability and odontogenic potential. We find that, while viscosity, and hence printability of the bioinks, was greater in the formulations containing higher concentrations of alginate, a higher proportion of insoluble dentin matrix proteins significantly improved cell viability; where a 1:1 ratio of alginate and dentin (1:1 Alg-Dent) was most suitable. We further demonstrate high retention of the soluble dentin molecules within the 1:1 Alg-Dent hydrogel blends, evidencing renewed interactions between these molecules and the dentin matrix post crosslinking. Moreover, at concentrations of 100 μg ml<sup>-1</sup>, these soluble dentin molecules significantly enhanced odontogenic differentiation of stem cells from the apical papilla encapsulated in bioprinted hydrogels. In summary, the proposed novel bioinks have demonstrable cytocompatibility and natural odontogenic capacity, which can be a used to reproducibly fabricate scaffolds with complex three-dimensional microarchitectures for regenerative dentistry in the future.
A 1.2V 8.3nJ energy-efficient CMOS humidity sensor for RFID applications (2012)

A CMOS fully-integrated humidity sensor for a RFID sensor platform has been realized in 0.16μm CMOS technology. It consists of a top-metal finger capacitor, covered by a humidity-sensitive polyimide layer, and an energy-efficient inverter-based capacitance-to-digital converter (CDC). Measurements show that the CDC performs a 12.5-bit conversion in 0.8ms while consuming only 8.6μA from a 1.2V supply. Together with the co-integrated humidity sensor, this translates into a resolution of 0.05% RH in the range of 30% RH to 90% RH, at an energy consumption of only 8.3nJ per measurement.
Modulazione dello stress ossidativo indotto in retina e nervo ottico da ipertensione oculare acuta: ruolo della L-carnitina e del suo inibitore metabolico THP (2010)

La carnitina riesce ad evitare il suicidio cellulare molto probabilmente sia perché riduce la presenza di radicali liberi sia perché stabilizza le membrane mitocondriali e aumenta l’efficienza metabolica dei mitocondri stessi incrementando quindi il consumo di ossigeno e substrati. Ciò viene confermato dall’effetto dei risultati ottenuti con l’inibitore metabolico THP (mildronato). In conclusione, la L-carnitina esogena riesce a migliorare l’omeostasi cellulare e protegge le cellule della retina e le cellule astrocitarie del nervo ottico dall’apoptosi indotta da ipertensione oculare acuta.
Studies of H5N1 Influenza Virus Infection of Pigs by Using Viruses Isolated in Vietnam and Thailand in 2004 (2005)

To determine whether avian H5N1 influenza viruses associated with human infections in Vietnam had transmitted to pigs, we investigated serologic evidence of exposure to H5N1 influenza virus in Vietnamese pigs in 2004. Of the 3,175 pig sera tested, 8 (0.25%) were positive for avian H5N1 influenza viruses isolated in 2004 by virus neutralization assay and Western blot analysis. Experimental studies of replication and transmissibility of the 2004 Asian H5N1 viruses in pigs revealed that all viruses tested replicated in the swine respiratory tract but none were transmitted to contact pigs. Virus titers from nasal swabs peaked on day 2, and low titers were detected in the liver of two of the four pigs tested. Our findings indicate that pigs can be infected with highly lethal Asian H5N1 viruses but that these viruses are not readily transmitted between pigs under experimental conditions.
Optimization Of Observation And Control Processes (1992)

This book generalizes the classic theory of the regression experiment design in the case of Kalman-type filtering in controllable dynamic systems. A new approach is proposed for optimization of the measurable parameters structure, of navigation mean modes, of the observability conditions, of inputs for system identification, etc. The developed techniques are applied for enhancing efficiency of spacecraft navigation and control.
Recent advances in micellar electrokinetic chromatography (2005)

This review contains nearly 200 reference citations, and covers advances in electrokinetic capillary chromatography based on micelles, including stabilized micelle complexes, polymeric and mixed micelles from 2003-2004. Detection strategies, analyte determinations, and applications in micellar electrokinetic capillary chromatography (MEKC) are discussed. Information regarding methods of analyte concentration, analyte specific analyses, and nonstandard micelles has been summarized in tabular form to provide a means of rapid access to information pertinent to the reader.
Topotactic Transformation of Zeolite Supported Cobalt(II) Hydroxide to Oxide and Comparison of Photocatalytic Oxygen Evolution (2013)

A synthesis method that results in ∼180 nm plate-like crystallites of β-(Co(OH)2 anchored on the surface of zeolite Y particles is reported. These crystals of β-Co(OH)2 are transformed to Co3O4 by thermal treatment without a change in morphology. Characterization of the cobalt phases and the transformation was carried out by powder X-ray diffraction, X-ray photoelectron spectroscopy, Raman spectroscopy, and electron microscopy. These cobalt-based materials provide an opportunity to contrast their photocatalytic activity. Using the Ru(bpy)32+−persulfate system, the oxidation of water to oxygen was measured. The most active catalyst was β-(Co(OH)2, and with transformation to Co3O4, the catalytic activity declined, suggesting that β-Co(OH)2 is a better photocatalyst than Co3O4. The photocatalytic activity of the β-(Co(OH)2/zeolite decreased during a second photocatalytic cycle, due to surface transformation to Co3O4, though the bulk of the catalyst still maintains the brucite-like β-Co(OH)2 structure. This is the first report on how catalytic activity is altered in the cobalt oxide system by phase transformation, keeping morphological features unchanged.
Novel HY peptide antigens presented by HLA-B27 (1997)

We have identified two peptides corresponding to the male-specific HY minor histocompatibility Ags presented by HLA-B27 in transgenic rodents, isolated from whole cell extracts and from immunoprecipitated B27 molecules of male B27 rat spleen cells. HPLC peptide fractions that sensitized female B27 targets for lysis by B27-restricted anti-HY CTL were analyzed by electrospray tandem mass spectrometry using a new highly sensitive quadrupole/time-of-flight instrument. Two peptide sequences were obtained, KQYQKSTER and AVLNKSNREVR. Synthetic peptides corresponding to these sequences bound B27 in vitro and were recognized by distinct B27-restricted anti-HY CTL populations. Neither peptide sequence entirely matches known protein sequences or shows a resemblance to known Y chromosome genes, but both show homology to known autosomally encoded proteins. Both peptides were shown to be controlled by the Sxr(b) segment of the short arm of the mouse Y chromosome, a segment known to contain all previously identified HY Ags. Taken together, these findings suggest that the two peptides arise as a result of Y chromosome-regulated control of one or more autosomal gene products. Although arginine at position 2 is a dominant anchor residue for peptides bound to B27, neither B27-presented HY sequence contains this residue. These studies, employing sensitive new methodology for identification of MHC-bound peptides, significantly extend the complexity of the genetic basis of HY Ags and expand the repertoire of antigenically active peptides bound to B27.
ROP GTPases Act with the Receptor-Like Protein PAN1 to Polarize Asymmetric Cell Division in Maize (2011)

Plant Rho family GTPases (ROPs) have been investigated primarily for their functions in polarized cell growth. We previously showed that the maize (Zea mays) Leu-rich repeat receptor-like protein PANGLOSS1 (PAN1) promotes the polarization of asymmetric subsidiary mother cell (SMC) divisions during stomatal development. Here, we show that maize Type I ROPs 2 and 9 function together with PAN1 in this process. Partial loss of ROP2/9 function causes a weak SMC division polarity phenotype and strongly enhances this phenotype in pan1 mutants. Like PAN1, ROPs accumulate in an asymmetric manner in SMCs. Overexpression of yellow fluorescent protein-ROP2 is associated with its delocalization in SMCs and with aberrantly oriented SMC divisions. Polarized localization of ROPs depends on PAN1, but PAN1 localization is insensitive to depletion and depolarization of ROP. Membrane-associated Type I ROPs display increased nonionic detergent solubility in pan1 mutants, suggesting a role for PAN1 in membrane partitioning of ROPs. Finally, endogenous PAN1 and ROP proteins are physically associated with each other in maize tissue extracts, as demonstrated by reciprocal coimmunoprecipitation experiments. This study demonstrates that ROPs play a key role in polarization of plant cell division and cell growth and reveals a role for a receptor-like protein in spatial localization of ROPs.
Left Atrial Appendage Activity Mimicking an Epsilon Wave on the Surface Electrocardiogram (2007)

Case Reports
Elbow arthroplasty for distal humeral fractures. (2014)

The treatment of comminuted, distal humeral fractures in elderly patients with osteoporotic bone is challenging. Total elbow arthroplasty or hemiarthroplasty are reliable treatment options with favorable outcomes for fractures that are not amenable to open reduction and internal fixation. Total elbow arthroplasty is a reliable option for a comminuted distal humeral fracture in an elderly patient with osteoporosis and low functional demands. Longer-term studies have shown good to excellent results and a low risk of complications. Specific indications for hemiarthroplasty are evolving, but include comminuted coronal shear or low transverse fractures in patients who have higher functional demands than those that can be met by total elbow arthroplasty. Further studies with longer-term follow-ups are needed to compare the benefits of hemiarthroplasty with total elbow arthroplasty.