gebhart/patrepeval huggingface dataset:
Development of affinity columns for the removal of high‐abundance proteins in cerebrospinal fluid (2009)

The gene encoding Psp HJ147 UDG (Psychrobacter sp. HJ147 uracil-DNA glycosylase) was cloned and sequenced. The gene consists of 735 bp for coding a protein with 244 amino acid residues. The deduced amino acid sequence of Psp HJ147 UDG showed a high similarity to that of Psychrobacter articus, Psychrobacter cryohalolentis K5 and Psychrobacter sp. PRwf-1. The PCR-amplified Psp HJ147 UDG gene was expressed under the control of the T7lac promoter on pTYB1 in Escherichia coli BL21(DE3). The expressed enzyme was purified with IMPACT-CN (intein-mediated purification with an affinity chitin-binding tag) system. The optimum pH and temperature of the purified enzyme were 7.0-7.5 and 20-25 degrees C respectively. The optimum NaCl and KCl concentrations for the activity of the purified enzyme ranged from 50 to75 mM. The half-life of the enzyme at 50 degrees C was approx. 45 s. These heat-labile characteristics enabled Psp HJ147 UDG to control carry-over contamination in direct PCR without loss of the PCR product. Psp HJ147 UDG's contaminant control in both direct PCR and indirect PCR exhibited superiority over the UDG of the marine psychrophilic bacterium strain BMTU 3346 and that of E. coli.
Design and control of sensorless current mode DC-DC converters (2003)

Sensorless current-mode (SCM) control of DC-DC converters is a feedforward open loop scheme, which is compared to peak current-mode (PCM) control. Small signal model simulations of each controller are validated by experimental results. SCM offers improvements over the line disturbance rejection of current-mode control without feedback or current sensing. SCM is demonstrated to be useful in both open loop and closed loop configurations, by exploiting its inherent reference tracking and line disturbance rejection. In contrast, PCM requires a high gain two-loop control for voltage regulation.
SALVAGE PROSTATE CRYOABLATION FOR PROSTATE CANCER: UPDATED RESULTS AND LONGER FOLLOW-UP BASED ON THE COLD REGISTRY (2008)

You have accessJournal of Urology1 Apr 2008SALVAGE PROSTATE CRYOABLATION FOR PROSTATE CANCER: UPDATED RESULTS AND LONGER FOLLOW-UP BASED ON THE COLD REGISTRY Louis L Pisters, J Stephen Jones, David Ellis, Bryan Donnelly, Aaron E Katz, Martin Dineen, Stephen Scionti, Franco Lugnani, and David M Jackson Louis L PistersLouis L Pisters More articles by this author , J Stephen JonesJ Stephen Jones More articles by this author , David EllisDavid Ellis More articles by this author , Bryan DonnellyBryan Donnelly More articles by this author , Aaron E KatzAaron E Katz More articles by this author , Martin DineenMartin Dineen More articles by this author , Stephen SciontiStephen Scionti More articles by this author , Franco LugnaniFranco Lugnani More articles by this author , and David M JacksonDavid M Jackson More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)61167-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "SALVAGE PROSTATE CRYOABLATION FOR PROSTATE CANCER: UPDATED RESULTS AND LONGER FOLLOW-UP BASED ON THE COLD REGISTRY." The Journal of Urology, 179(4S), p. 399 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 399 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Louis L Pisters More articles by this author J Stephen Jones More articles by this author David Ellis More articles by this author Bryan Donnelly More articles by this author Aaron E Katz More articles by this author Martin Dineen More articles by this author Stephen Scionti More articles by this author Franco Lugnani More articles by this author David M Jackson More articles by this author Expand All Advertisement PDF downloadLoading ...
Chaos, an intelligent ultra-mobile SUGV: combining the mobility of wheels, tracks, and legs (2005)

Autonomous Solutions has developed Chaos, a small unmanned ground vehicle with four modular running gear receptacles. Running gear attached to the vehicle can include any combination of wheels, tracks, articulated and shape-shifting tracks, and legs. Each unit is independently controllable and field changeable. This modular design allows Chaos to combine the strengths of traditional and bio-inspired locomotion. The vehicle offers unprecedented mobility potential including walking, stair climbing, clambering over obstacles, steep slope traversal and extrication. To fully exploit the vehicle's mobility potential, intelligent behaviors must be integrated to reduce the complexity of vehicle operation. Mobility behaviors include operator assisted tele-operation, adaptive gaits, obstacle characterization, traversal, and extrication. This paper will describe the design and development of Chaos including running gear and intelligent mobility behaviors.
Improving best‐phase image quality in cardiac CT by motion correction with MAM optimization (2013)

The proposed method allows a software-based best-phase image quality improvement in coronary CT angiography. A short scan data interval at the target heart phase is sufficient, no additional scan data in other cardiac phases are required. The algorithm is therefore directly applicable to any standard cardiac CT acquisition protocol.
HuTrain: a Framework for Fast Creation of Real Human Pose Datasets (2020)

Image-based body tracking algorithms are useful in several scenarios, such as avatar animations and gesture interaction for VR applications. In the last few years, the best-ranked solutions presented on the state of the art of body tracking (according to the most popular datasets in the field) are intensively based on Convolutional Neural Networks (CNNs) algorithms and use large datasets for training and validation. Although these solutions achieve high precision scores while evaluated with some of these datasets, there are particular tracking challenges (for example, upside-down cases) that are not well-modeled and, therefore, not correctly tracked. Instead of lurking an all-in-one solution for all cases, we propose HuTrain, a framework for creating datasets quickly and easily. HuTrain comprises a series of steps, including automatic camera calibration, refined human pose estimation, and known dataset formats conversion. We show that, with our system, the user can generate human pose datasets, targeting specific tracking challenges for the desired application context, with no need to annotate human pose instances manually.
Identification of domains and domain interface residues in multidomain proteins from graph spectral method (2005)

We present a novel method for the identification of structural domains and domain interface residues in proteins by graph spectral method. This method converts the three-dimensional structure of the protein into a graph by using atomic coordinates from the PDB file. Domain definitions are obtained by constructing either a protein backbone graph or a protein side-chain graph. The graph is constructed based on the interactions between amino acid residues in the three-dimensional structure of the proteins. The spectral parameters of such a graph contain information regarding the domains and subdomains in the protein structure. This is based on the fact that the interactions among amino acids are higher within a domain than across domains. This is evident in the spectra of the protein backbone and the side-chain graphs, thus differentiating the structural domains from one another. Further, residues that occur at the interface of two domains can also be easily identified from the spectra. This method is simple, elegant, and robust. Moreover, a single numeric computation yields both the domain definitions and the interface residues.
On the number of acceptable task assignments in distributed computing systems (1990)

A distributed computing system and cooperating tasks can be represented by a processor graph G/sub p/=(V/sub p/, E/sub p/) and a task graph G/sub T/=(V/sub T/, E/sub T/), respectively. An edge between a pair of nodes in G/sub T/ represents the existence of direct communications between the two corresponding tasks. The maximal number of hops between two processors in G/sub p/ to which two adjacent tasks in G/sub T/ are assigned is called dilation of that assignment. Characterization and use of the number of acceptable assignments for given G/sub T/ and G/sub P/ are treated. Assignments with the dilation less than or equal to one are considered. This dilation constraint represents a special case in which two adjacent tasks in G/sub T/ must be assigned to either a single processor or two adjacent processors in G/sub p/. For the case where N(G/sub T/, G/sub P/) denotes the numbers of acceptable assignments under this constraint, N(G/sub T/, G/sub P/) are derived for arbitrary G/sub T/ and G/sub P/, and a recursive expression is formulated for N(G/sub T/, G/sub P/) when G/sub T/ is a tree. For some restricted cases, either closed-form or recursive-form expressions of N(G/sub T/, G/sub P/) are derived. The results on N(G/sub T/, G/sub P/) are extended to the completely general case, assignments with dilations greater than one, where two adjacent tasks in G/sub T/ can be assigned to any two processors in G/sub P/ which are not necessarily adjacent to each other.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Fabrication of Second Skin from Keratin and Melanin (2020)

Second skin is a topically applied, skin-conforming material that mimics human skin properties and bears potential cosmetic and e-skin applications. To successfully integrate with natural skin, characteristics such as color and skin features must be matched. In this work, we prepared bio-based skin-like films from cross-linked keratin/melanin films (KMFs), using a simple fabrication method and non-toxic materials. The films retained their stability in aqueous solutions, showed skin-like mechanical properties, and were homogenous and handleable, with non-granular surfaces and a notable cross-linked structure as determined by attenuated total reflection (ATR). In addition, the combination of keratin and melanin allowed for adjustable tones similar to those of natural human skin. Furthermore, KMFs showed light transmittance and UV-blocking (up to 99%) as a function of melanin content. Finally, keratin/melanin ink (KMI) was used to inkjet-print high-resolution images with natural skin pigmented features. The KMFs and KMI may offer advanced solutions as e-skin or cosmetics platforms.
Metallkomplexe mit funktionalisierten Schwefelliganden. XIV. Synthese von Thiosulfinatokomplexen über die Oxidative Addition von Platin(0)-Komplexen an 2,3,4-Benzotrithiepin-1-oxid (1999)

The platinum(0) compounds L2Pt(η2-C2H4) [L = PPh3, 1/2 dppf, 1/2 (R,R)-(–)-DIOP] 3a–c react with the 2,3,4-benzotrithiepin 1-oxides 2a–c to give the platinum(II) thio-lato thiosulfinato complexes L2Pt[S–S(O)–CH2–C6R12R22-CH2–S] (R1 = H, R2 = CH3; R1 = CH3, R2 = H) 4a–6c. Treatment of 5a with an excess of PBu3 efficiently affords (Bu3P)2Pt[S–S(O)–CH2–C6Me2H2–CH2–S] 7 by substitution of PPh3. Complex 7 reacts in solution with PBu3 to the platinum(II) sulfenato thiolato complex (Bu3P)2Pt[S(O)–CH2–C6Me2H2–CH2–S] 8 as well as S=PBu3. The compounds 4a–6c have been characterized by analytical and spectroscopic methods. Simple qualitative MO calculations of the extended Hückel type by using the CACAO package indicate that the platinum(0) species acts as a Lewis acid attacking the nucleophilic sulfur atom S(3).
COVID-19, science, vaccines and family in a multi origin Latinx population in South Florida (2022)

During the Spring of 2021 in Miami-Dade County, four virtual focus groups were held with 31 participants from four diverse local Latinx communities as part of the Florida Community Engagement Alliance (FL-CEAL) Against COVID-19 Disparities project. The main objective was to explore attitudes about COVID-19 information and prevention strategies among South Florida's diverse Latinx populations, across a broad geographical area. The study used a semi-structured focus group qualitative design and chose participants from four well established Latinx neighborhoods. Participants were mostly women, diversity was strong with birth regions including the Caribbean, North, Central and South America. Though a third (<i>n</i> = 11) were born in the United States, almost all (<i>n</i> = 28) reported speaking Spanish at home. Three themes and six subthemes were identified to underscore Latinx attitudes toward COVID-19 vaccine uptake or hesitancy. These were: (1) Attitudes regarding vaccine intake; (2) Sources of Information; and (3) Science Education. The degree to which each of these themes exercised influence on vaccine intake or hesitancy varied. The multi origin Latinx participation in the focus groups strengthened findings by broadening representation and discussion. In the end and despite the various national origins, all participants indicated receiving most of their information on COVID-19 related topics from their family, physicians, social networks, and some form of media.
Characterization of special fibers and fiber devices (1989)

Methods for characterizing birefringent fibers (both those with high circular or linear birefringence and those with negligible intrinsic birefringence) are presented, and their relative merits are discussed. Fibers with high nonlinear coefficients exhibit interesting optical phenomena, and methods are developed to determine second harmonic, Pockels and Kerr effects, parametric phenomena, and the Verdet constant of silica and higher-loss, nonsilica fibers. Fibers containing rare-earth ions are of interest both as active (laser and amplifiers) and passive systems. Techniques are developed to characterize these devices, and conventional methods are modified to quantify dopant parameters within the fiber. Techniques for the measurement of the diverse properties of all these different fibers are presented with results, and, where appropriate, the problems with their characterization are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Activation of the Calcium Sensing Receptor Decreases Secretagogue-Induced Fluid Secretion in the Rat Small Intestine (2019)

This study concludes that apical CaSR is active along the small intestine. Its activation by Ca<sup>2+</sup> and/or calcimimetics reduces fluid secretion in a dose-dependent manner, with higher Ca<sup>2+</sup> concentrations, or application of a calcimimetic, leading to fluid absorption. We furthermore show that, in the presence of FSK, receptor activation abates FSK secretagogue-induced fluid secretion. This presents a new therapeutic target to address secretory diarrheal illnesses.
A Study of Sense of Self-agency Focused on Cross-correlation and Delay Between Action and Effect in Continuous Operation (2016)

Sense of self-agency has been proposed in psychology field, and it is the sense that I am the initiator or source of the action. We discuss it on continuous operation to find out the transition of the sense for a change of delay and cross-correlation that is the degree of noise between an action as an input signal and its effect as an output signal. We conclude that sense of self-agency is affected by both of a cross-correlation and a delay, human gets stronger sense of self-agency when cross-correlation between action and effect is higher, and an acceptable noise and delay to feel enough good operational feeling may be predicted.
Aryl hydrocarbon receptor deficiency causes the development of chronic obstructive pulmonary disease through the integration of multiple pathogenic mechanisms (2021)

Emphysema, a component of chronic obstructive pulmonary disease (COPD), is characterized by irreversible alveolar destruction that results in a progressive decline in lung function. This alveolar destruction is caused by cigarette smoke, the most important risk factor for COPD. Only 15%-20% of smokers develop COPD, suggesting that unknown factors contribute to disease pathogenesis. We postulate that the aryl hydrocarbon receptor (AHR), a receptor/transcription factor highly expressed in the lungs, may be a new susceptibility factor whose expression protects against COPD. Here, we report that Ahr-deficient mice chronically exposed to cigarette smoke develop airspace enlargement concomitant with a decline in lung function. Chronic cigarette smoke exposure also increased cleaved caspase-3, lowered SOD2 expression, and altered MMP9 and TIMP-1 levels in Ahr-deficient mice. We also show that people with COPD have reduced expression of pulmonary and systemic AHR, with systemic AHR mRNA levels positively correlating with lung function. Systemic AHR was also lower in never-smokers with COPD. Thus, AHR expression protects against the development of COPD by controlling interrelated mechanisms involved in the pathogenesis of this disease. This study identifies the AHR as a new, central player in the homeostatic maintenance of lung health, providing a foundation for the AHR as a novel therapeutic target and/or predictive biomarker in chronic lung disease.
Fiber Bragg grating strain sensor interrogation with 1.3 μm Fourier domain mode-locked wavelength swept laser (2009)

We demonstrate a high speed fiber Bragg grating sensor array interrogation using 1.3 &mu;m Fourier-domain modelocked (FDML) wavelength-swept laser. The slope coefficients for measured relative wavelength difference and relative time delay from the static strain are 1.02 pm/&mu;strain and 0.16 ns/&mu;strain, respectively. We demonstrate the dynamic response of the FBG sensor array with 100 Hz modulation strain based on the FDML wavelength swept laser at 25.3 kHz scanning rate. The FBG sensor interrogation system using FDML wavelength swept laser can be realized for the high speed and high sensitivity monitoring systems.
Scalable and Adaptive KNN for Regression Over Graphs (2019)

The family of k-nearest neighbor ( k NN) schemes comprises simple and effective algorithms that can be used for general machine learning tasks such as classification and regression. The goal of linear k NN regression is to predict the value of an unseen datum as a linear combination of its k neighbors on a graph, which could be found via certain distance metric. Despite the simplicity and effectiveness of kNN regression, a general problem facing this approach is the proper choice of k. Most of the conventional k NN algorithms simply apply the same k for all data samples, meaning that the data samples are assumed to lie on a regular graph wherein each data sample is connected with k neighbors. However, a constant choice may not be optimal for data lying in a heterogeneous feature space. On the other hand, existing algorithms for adaptively choosing k usually incur high computational complexity, especially for large training datasets. In order to cope with this challenge, this paper introduces a novel algorithm which can adaptively choose k for each data sample; meanwhile it is capable of greatly reducing the training complexity by actively choosing training samples. Real data tests corroborate the efficiency and effectiveness of the novel algorithm.
Enhanced Scintillation Light Extraction Using Nanoimprinted Photonic Crystals (2018)

The extraction of scintillation light from a crystal with high efficiency and low time jitter is vital for realizing much-needed gains in the performance of numerous radiation detection and imaging instruments that are vital components in medical imaging, industrial, and homeland security applications for the detection, localization, and energy classification of X-rays, γ-rays, or neutrons. Nanostructures such as photonic crystals (PhCs) maximize extraction of usable scintillation light that is otherwise lost when a high refractive index (RI) scintillator is coupled to a photodetector with low RI window. The PhC gradually changes the RI between the scintillator and photodetector, thereby substantially improving the light extraction efficiency, as well as the energy resolution (ER) and timing resolution. Here, we report on improvements in the light extraction and ER of inorganic scintillators using PhCs nanoimprinted in high RI polymers. Details of the design, fabrication, and characterization of the PhCs, the high RI polymers, and their impact on scintillator performance are presented here.
Inside bloody lymphatics (2010)

Lymphatic vessels were missed by many pathologists for centuries because they do not contain red blood cells. Yet the reason for this has been illuminated only now in several articles in Blood.
New sustained release dosage form of chlorhexidine for dental use: use for plaque control in partial denture wearers (1984)

The aim of this work was to test the effectiveness of a local sustained release application of chlorhexidine in prevention of plaque formation in a group of five partial denture wearers when oral hygiene procedures were withdrawn. The clinical study demonstrates that coating of the partial dentures with ethyl cellulose polymer containing the drug, prevents accumulation of plaque during a period of 12 days. No typical side effects of chlorhexidine such as tooth staining and unpleasant taste were observed during the study.
15‐Methylene‐Eburnamonine Kills Leukemic Stem Cells and Reduces Engraftment in a Humanized Bone Marrow Xenograft Mouse Model of Leukemia (2016)

Recent studies suggest that leukemia stem cells (LSCs) play a critical role in the initiation, propagation, and relapse of leukemia. Herein we show that (-)-15-methylene-eburnamonine, a derivative of the alkaloid (-)-eburnamonine, is cytotoxic against acute and chronic lymphocytic leukemias (ALL and CLL) and acute myelogenous leukemia (AML). The agent also decreases primary LSC frequency in vitro. The cytotoxic effects appear to be mediated via the oxidative stress pathways. Furthermore, we show that the compound kills AML, ALL, and CLL stem cells. By the use of a novel humanized bone marrow murine model of leukemia (huBM/NSG), it was found to decrease progenitor cell engraftment.
Testing of Newly Developed Wide-Field Dual-Array Suprachoroidal–Transretinal Stimulation Prosthesis in Dogs (2021)

This study suggests that this wide-field dual-array prosthesis might widen the visual field and might be useful for patients with retinitis pigmentosa.
Optimized visualization of vessels in contrast enhanced intracranial MR angiography (1998)

In this study, the problem of small vessel visualization in magnetic resonance angiography is addressed. The loss of vessel contrast due to slow flow-related signal saturation can be compensated by the T1 reduction obtained from the use of an MR contrast agent, such as Gd-DTPA. The vessel/background signal-difference-to-noise ratio (SDNR) is shown to strongly depend on the imaging parameters, as well as on the time course of the blood T1 values obtained from the contrast injection. Specifically, it was found that vessel SDNR increases almost linearly with TR, if the sampling bandwidth is reduced proportionately.
THE CEMENTED ALL-POLY TIBIA: REGARDLESS OF AGE AND BMI – AFFIRMS (2019)

Total knee replacement (TKA) is one of the most successful procedures in orthopaedic surgery. Although originally limited to more elderly and less active individuals, the inclusion criteria for TKA...