gebhart/patrepeval huggingface dataset:
Concurrent left ventricular myocardial diffuse fibrosis and left atrial dysfunction strongly predicts incident heart failure and all-cause mortality (2023)

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): British Heart Foundation Academy of Medical Sciences Background LV myocardial interstitial fibrosis has been reported to influence LA morphology and function via LV remodelling and diastolic dysfunction. However, this association, as well as their combined influence on clinical outcomes remains poorly characterised. Aim To evaluate the relationship between left ventricular (LV) fibrosis quantified by native T1 times and left atrial (LA) global and phasic function and their impact on clinical outcomes. Methods A total of 40,818 UK Biobank participants with cardiovascular magnetic resonance data were included. Native T1 mapping was performed using Shortened Modified Look-Locker Inversion recovery sequence with global myocardial T1 estimated by an automatic segmentation framework. Ten parameters of LA phasic function were calculated from normalised LA volume-time curves derived by a three-dimensional sparse active shape model. LV parameters (mass, end-diastolic volume, and ejection fraction) were extracted by a fully convolutional neural network. Multivariable regression models were used to assess the associations between T1 and LA parameters. Lastly, survival analysis was performed to assess the interplay between T1, LA function and incident heart failure, atrial fibrillation, major adverse cardiovascular event (MACE) and all-cause mortality. Results The mean age of study population was 64.0 ± 7.7 years; 47.8% were men. Higher T1 values were associated with larger LA minimum size (Beta= 0.89ml per 100ms; 95% confidence interval (CI) = 0.62, 1.17), and lower LA global emptying fraction (Beta= -0.012 per 100ms; CI= -0.015, -0.010), LA reservoir function (Beta= -0.060 per 100ms; CI= -0.083, -0.037) and LA booster function (Beta= -0.014 per 100ms; CI= -0.017, -0.011). Among LA phasic functional parameters, LA booster function is most strongly associated with T1. Survival analysis revealed concurrent high T1 and low LA function had a significant influence on incident heart failure (Hazard Ratio [HR] = 2.99; CI=1.91,2.01), atrial fibrillation (HR = 4.86; CI=3.51-6.54), MACE (HR = 1.86; CI = 1.36-2.54) and all-cause mortality (HR = 1.86; CI=1.22-2.82) compared to either parameter alone, even after accounting for LV parameters (Figure 1). Conclusion This is the first study to robustly demonstrate the associations between myocardial diffuse fibrosis and reduced LA global and phasic functional measurements. We reveal the independent prognostic role of high T1 values accompanied by low LA function in predicting adverse clinical outcomes in a general population. These findings advance our understanding of the relationships between myocardial fibrosis and LA biomechanics at an early, subclinical stage, and highlight the additive value of incorporating these biomarkers into clinical decision making.
FPGA-based lens undistortion and image rectification for stereo vision applications (2019)

Lens undistortion and image rectification is a commonly used pre-processing, e.g. for active or passive stereo vision to reduce the complexity of the search for matching points. The undistortion and rectification is implemented in a field programmable gate array (FPGA). The algorithm is performed pixel by pixel. The challenges of the implementation are the synchronisation of the data streams and the limited memory bandwidth. Due to the memory constraints, the algorithm utilises a pre-computed lossy compression of the rectification maps by a ratio of eight. The compressed maps occupy less space by ignoring the pixel indexes, sub-sampling both maps, and reducing repeated information in a row by forming differences to adjacent pixels. Undistorted and rectified images are calculated once without and once with the compressed transformation map. The deviation between the different computed images is minimal and negligible. The functionality of the hardware module, the decompression algorithm and the processing pipeline are described. The algorithm is validated on a Xilinx Zynq-7020 SoC. The stereo setup has a baseline with 46 mm and non-converged optical axis between the cameras. The cameras are configured at 1.3 Mpix @ 60 fps and distortion correction and rectification is performed in real time during image capture. With a camera resolution of 1280 pixels × 960 pixels and a maximum vertical shift of &plusmn; 20 pixels, the efficient hardware implementation utilizes 12 % of available block RAM resources.
Hybridization-based capture of pathogen mRNA enables paired host-pathogen transcriptional analysis (2019)

Dual transcriptional profiling of host and bacteria during infection is challenging due to the low abundance of bacterial mRNA. We report Pathogen Hybrid Capture (PatH-Cap), a method to enrich for bacterial mRNA and deplete bacterial rRNA simultaneously from dual RNA-seq libraries using transcriptome-specific probes. By addressing both the differential RNA content of the host relative to the infecting bacterium and the overwhelming abundance of uninformative structural RNAs (rRNA, tRNA) of both species in a single step, this approach enables analysis of very low-input RNA samples. By sequencing libraries before (pre-PatH-Cap) and after (post-PatH-Cap) enrichment, we achieve dual transcriptional profiling of host and bacteria, respectively, from the same sample. Importantly, enrichment preserves relative transcript abundance and increases the number of unique bacterial transcripts per gene in post-PatH-Cap libraries compared to pre-PatH-Cap libraries at the same sequencing depth, thereby decreasing the sequencing depth required to fully capture the transcriptional profile of the infecting bacteria. We demonstrate that PatH-Cap enables the study of low-input samples including single eukaryotic cells infected by 1-3 Pseudomonas aeruginosa bacteria and paired host-pathogen temporal gene expression analysis of Mycobacterium tuberculosis infecting macrophages. PatH-Cap can be applied to the study of a range of pathogens and microbial species, and more generally, to lowly-abundant species in mixed populations.
Electron Tomography of Quantum Dot Bioconjugates (2011)

Extended abstract of a paper presented at Microscopy and Microanalysis 2011 in Nashville, Tennessee, USA, August 7–August 11, 2011.
Creating a Protein-Based Element of Inheritance (2000)

Proteins capable of self-perpetuating changes in conformation and function (known as prions) can serve as genetic elements. To test whether novel prions could be created by recombinant methods, a yeast prion determinant was fused to the rat glucocorticoid receptor. The fusion protein existed in different heritable functional states, switched between states at a low spontaneous rate, and could be induced to switch by experimental manipulations. The complete change in phenotype achieved by transferring a prion determinant from one protein to another confirms the protein-only nature of prion inheritance and establishes a mechanism for engineering heritable changes in phenotype that should be broadly applicable.
Quantitative stiffness assessment of cardiac grafts using ultrasound in a porcine model: A tissue biomarker for heart transplantation (2022)

FRM PME20170637799, Agence Biomédecine AOR Greffe 2017, ANR-18-CE18-0015.
ChemInform Abstract: STUDIES OF HETEROCYCLIC COMPOUNDS PART 17, SYNTHESIS OF 1,6‐DIOXA‐6A‐THIA‐ AND 1,6‐DIOXA‐6A‐SELENA‐PENTALENES (1975)

Abstract Die Pyranthione (I) reagieren mit TKIID‐trifluoracetat (II) über die Pyryliumtrifluoracetate (III) zu den Thiapentalenen (IV).
A Visual Representation for Editing Face Images (2016)

We propose a new approach for editing face images, which enables numerous exciting applications including face relighting, makeup transfer and face detail editing. Our face edits are based on a visual representation, which includes geometry, face segmentation, albedo, illumination and detail map. To recover our visual representation, we start by estimating geometry using a morphable face model, then decompose the face image to recover the albedo, and then shade the geometry with the albedo and illumination. The residual between our shaded geometry and the input image produces our detail map, which carries high frequency information that is either insufficiently or incorrectly captured by our shading process. By manipulating the detail map, we can edit face images with reality and identity preserved. Our representation allows various applications. First, it allows a user to directly manipulate various illumination. Second, it allows non-parametric makeup transfer with input face's distinctive identity features preserved. Third, it allows non-parametric modifications to the face appearance by transferring details. For face relighting and detail editing, we evaluate via a user study and our method outperforms other methods. For makeup transfer, we evaluate via an online attractiveness evaluation system, and can reliably make people look younger and more attractive. We also show extensive qualitative comparisons to existing methods, and have significant improvements over previous techniques.
Using Constrained β‐Amino Acid Residues to Control β‐Peptide Shape and Function (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Dual-Wavelength Pumped 1.550μm High-Power Optical Parametric Chirped-Pulse Amplifier System (2010)

A 1.550 μm OPCPA utilizing a dual wavelength pumping scheme has been constructed. The system incorporates LBO and KTA for the first and second-stage amplifiers. Peak powers &gt;310GW (60mJ, 180fs) at 10Hz have been achieved.
A Compound with a Boron–Arsenic Double Bond (1990)

A BAs distance of 1.926 Å and a considerable restriction of rotation around the central BAs axis are unequivocal indications of a BAs π interaction in the arsanediylborate 1. Orange-red crystals of 1 are obtained in 59% yield from MeS2BF and Li2AsPh in THF.
Microwave antenna array for high temperature material processing (2010)

Industrial scale high temperature microwave processing of materials, like e.g., dielectric heating for sintering or heat treatment of powder metals and ceramics has not been successful yet, mainly because of lack of suitable equipment. The paper presents results of antenna development aiming at 2.45 GHz microwave transmission into hot processing chambers, with minimum heat loss because only minor cooling of windows or transmission lines is required. High power microwave coupling is enabled by an array of high temperature resistant rod antennas. The design is performed in two steps: first simulation (FDTD) and experimental validation is done for a single antenna, than the results are transferred into the design of a 6 antenna array. This antenna array is capable of transmitting up to 36 kW 2.45 GHz radiation into a 1 m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> volume process chamber at temperatures up to 1500°C. The homogeneity of E-H-field distribution in the chamber and the limitations of material selection for the antenna array are discussed.
3D printing of metal-based materials for renewable energy applications (2020)

Large-scale renewable energy must overcome conversion and storage challenges before it can replace fossil fuels due to its intermittent nature. However, current sustainable energy devices still suffer from high cost, low efficiency, and poor service life problems. Recently, porous metal-based materials have been widely used as desirable cross-functional platforms for electrochemical and photochemical energy systems for their unique electrical conductivity, catalytic activity, and chemical stability. To tailor the porosity length scale, ordering, and compositions, 3D printing has been applied as a disruptive manufacturing revolution to create complex architected components by directly joining sequential layers into designed structures. This article intends to summarize cutting-edge advances of metal-based materials for renewable energy devices (e.g., fuel cells, solar cells, supercapacitors, and batteries) over the past decade.
Profile of Serogroup Y Meningococcal Infections in Canada: Implications for Vaccine Selection (2009)

Canada is a leader in establishing routine infant immunization programs against meningococcal C disease. Currently, all provinces have routine programs to provide meningococcal C conjugate vaccines to infants and children. The result of the existing programs has been a decrease in serogroup C incidence. The second most common vaccine-preventable serogroup in Canada is serogroup Y, the incidence of which has been stable. The availability of a quadrivalent conjugate vaccine against serogroups A, C, Y and W135 focuses attention on serogroup Y disease as it becomes relatively more prominent as a cause of vaccine-preventable invasive meningococcal disease. This vaccine was licensed in November 2006 but is not routinely used except in Nunavut, New Brunswick and Prince Edward Island. To allow a better understanding of the 'value added' by a serogroup Y-containing vaccine, it is necessary to have a contemporary profile of Y disease in Canada. In the present paper, recent surveillance data on invasive meningococcal disease across Canada are summarized.
Monocyte biomarkers define sargramostim treatment outcomes for Parkinson's disease (2022)

This monocyte profile provides an "early" and unique biomarker strategy to track clinical immune-based interventions, but requiring validation in larger case studies.
Energy enhancement for deuteron beam fast ignition of a precompressed inertial confinement fusion target (2011)

Fast Ignition (FI) is recognized as a potentially promising approach to achieve the high-energy-gain target performance needed for commercial inertial confinement fusion. Here we consider deuteron beam driven FI which provides not only the “hot spot” ignition spark, but also extra “bonus” fusion energy through reactions in the target. In this study, we estimate the impact of the added deposition energy due to the fusion reactions occurring, based on calculations using a modified energy multiplication factor Fc. The deuteron beam energy deposition range and time are also evaluated in order to estimate the desired deuteron initial energy. It is shown that an average of 30% extra energy can be gained from deuterons with 1 MeV initial energy and 12% from deuterons with 3 MeV initial energy. These results indicate that the energy benefit of this approach could be significant, but a much more comprehensive calculation is needed to realize a full 3D design for realistic experimental studies.
Essential features of the polytypic charoite-96 structure compared to charoite-90 (2011)

Abstract Charoite, ideally (K,Sr,Ba,Mn) 15–16 (Ca,Na) 32 [(Si 70 (O,OH) 180 )](OH,F) 4 · n H20, is a rock-forming mineral from the Murun massif in Yakutia, Sakha Republic, Siberia, Russia, where it occurs in a unique alkaline intrusion. Charoite occurs as four different polytypes, which are commonly intergrown in nanocrystallme fibres. We report the structure of charoite-96 (a = 32.11(6), b = 19.77(4), c = 7.23(1) Å, β = 95.85(9)°, V = 4565(24) Å 3 , space group P2 1 /m), which was solved ab initio by direct methods on the basis of 2676 unique electron diffraction reflections collected by automated diffraction tomography and refined to R 1 /wR 2 = 0.34/0.37. The structure of charoite-96 is related to that of the charoite-90, which was also solved recently. Both structures are composed of three different types of dreier silicate chains running along [001] and separated by ribbons of edge-sharing Ca- and Na-centred octahedra. In the structure of charoite-96, adjacent blocks formed by three different silicate chains and stacked along the x axis, are shifted by a translation of 1/2 c . The shifts involve a hybrid dreier quadruple chain, [Si 17 O 43 ] 18– and a double dreier chain, [Si 6 O 17 ] 10– . In charoite-90 adjacent blocks are stacked without shifts.
Shape memory alloy actuator controller design for tactile displays (2002)

This paper describes the design of a controller for a tactile shape display for dexterous telemanipulation applications. This device consists of an array of pin elements which rest against the human finger tip. Shape memory alloy (SMA) wire actuators raise individual pins to approximate the desired surface shape on the skin. To overcome the slow response times of SMA actuators we have implemented a feedforward derivative compensator and pneumatic cooling. The hysteretic and nonlinear response of the SMA actuators required the use of a closed loop controller with position feedback using an optical emitter-receiver pair. This also improves robustness to the load variations which result from human interaction.
Fast In-Memory Triangle Listing for Large Real-World Graphs (2014)

Triangle listing, or identifying all the triangles in an undirected graph, is a very important graph problem that serves as a building block of many other graph algorithms. The compute-intensive nature of the problem, however, necessitates an efficient method to solve this problem, especially for large real-world graphs. In this paper we propose a fast and precise in-memory solution for the triangle listing problem. Our solution includes fast common neighborhoods finding methods that consider power law degree distribution of real-word graphs. We prove how theoretic lower bound can be achieved by sorting the nodes in the graph by their degree and applying pruning. We explain how our techniques can be applied automatically by an optimizing DSL compiler. Our experiments show that hundreds of billions of triangles in a five billion edge graph can be enumerated in about a minute with a single server-class machine.
Non-aggregating octasubstituted dendritic phthalocyanines (2003)

Eight poly(aryl) ether dendritic wedges attached to the periphery of a phthalocyanine significantly decreases self-association of these chromophores in solution and the condensed state.
Heat Stress and Chilling Sensitivity of Tomato Fruit (1997)

Mature green `Sunbeam' tomato fruit ( Lycopersicon esculentum Mill.) were treated in water for 1 hr at 27 (ambient), 39, 42, 45, or 48°C, and then either ripened at 20°C (nonchilled) or stored at 2°C (chilled) for 14 days before ripening at 20°C. The most-effective heat treatment was 42°C, which reduced decay 67% in chilled fruit and 53% in nonchilled fruit. Heat treatment had no effect on time required to ripen the fruit. Red-ripe tomatoes had higher respiration rates and evolved more ethylene following nonchilling storage, but heat treatment had no effect on respiration or ethylene evolution. Red color development was enhanced by heat treatment, and inhibited by chilling. At red ripe, fruit were firmer as a result of storage at the chilling temperature, while heat treatment had no effect on firmness. Heat-treated fruit were preferred in terms of taste and texture over nontreated fruit in informal taste tests, with the exception of the 45°C treatment. With increasing temperature of heat treatment, there was increased electrolyte leakage following chilling storage. Of the 15 flavor volatiles analyzed, the levels of five were decreased with increasing temperature of heat treatment. Storage at the chilling temperature reduced the levels of six flavor volatiles. Prestorage heat treatments can reduce decay with only minimal adverse effects on tomato fruit quality.
Characterization of Fatty Acid Transport across Human Brain Microvessel Endothelial Cells (HBMECs) (2009)

Endothelial cells lining the blood capillaries of the Blood Brain Barrier (BBB) are tightly packed thus regulating the transport of substances from the blood into the brain, including fatty acids. Fatty acids are essential for both the developing and adult mammalian brain. Since most fatty acids in the brain enter from the blood, we examined the mechanism of their transport across Human Brain Microvessel Endothelial Cells (HBMECs). HBMECs were plated onto transwell plate inserts and then incubated for up to 4 h with [1‐14C]oleate in the apical medium. Radioactivity in the basolateral medium was temporally examined. There was a near linear increase in [1‐14C]oleate incorporation into the basolateral media in the presence of albumin indicating a protein acceptor is required for oleate transport. The presence of phloretin, a non‐specific fatty acid uptake inhibitor, significantly decreased [1‐14C]oleate transport into the basolateral medium. In addition, siRNA knockdown of fatty acid transport protein‐1 (FATP‐1) or fatty acid translocase (FAT/CD36) significantly decreased [1‐14C]oleate incorporation into the basolateral media. In summary, transport of oleate across HBMECs is, in part, a transcellular process. Oleate transport across HBMECs is mediated by both diffusion and carrier mediated processes. (Supported by the Manitoba Health Research Council and the Canadian Institutes of Health Research)
Prediction of rotor position at standstill and flying shaft conditions in switched reluctance machines (2004)

Development of a reliable, smooth, and precise position sensorless startup routine is an integral part of the switched reluctance machine (SRM) control. The proposed sensorless startup method presented in this paper represents high grade performance and does not require additional hardware or memory. Further, the proposed sensorless technique is extended to flying shaft conditions. These capabilities are highly demanded by automotive applications such as starter/alternator and electric power steering systems. An assessment of the impact of motor parameters and diagnostic signal measurement on the quality of the sensorless startup method is also included. This will help practicing engineers to make judicious selections for implementation of the proposed technique. Experimental and theoretical results are included to validate our claims.
Failure to detect conventional enterotoxins in classical enteropathogenic (serotyped) Escherichia coli strains of proven pathogenicity (1982)

Ammonium sulfate-precipitated supernatants of classical enteropathogenic Escherichia coli strains were negative when investigated for enterotoxin production in rabbit ligated ileal loops, rabbit skin vascular permeability factor tests, suckling mice, and Y-1 adrenal cells. They also failed to stimulate guanylate cyclase activity in homogenates of rabbit, rat, and infant mouse intestines. Furthermore, DNA from enteropathogenic E. coli lacked sequences that encode heat-labile and heat-stable enterotoxins. These studies fail to show conventional enterotoxin synthesis by classical enteropathogenic E. coli.