gebhart/patrepeval huggingface dataset:
Asymmetric Crossing-Shock-Wave/Turbulent-Boundary-Layer Interaction (1995)

A collaborative experimental and theoretical study of the asymmetric crossing-shock- wave/turbulent-boundarylayer interaction is presented. The shock waves are generated by a pair of asymmetric fins that are mounted normal to a flat plate and form a converging channel. The focus of the study is the interaction of the shock waves with the turbulent boundary layer on the flat plate. Two configurations with fin angles 7 X 11 and 15 x 11 deg have been examined at Mach 3.9. Experimental data include surface pressure and heat transfer, adiabatic wall temperature, surface flow visualization, and planar laser scattering images. The computations solve the three-dimensional Reynolds-averaged compressible Navier-Stokes equations incorporating the two equation Chien k-e turbulence model. The computed surface pressure displays good agreement with experiment. The computed and experimental surface pressure and flowfield flow visualization are in general agreement. The computed surface heat transfer displays significant disagreement with experiment. The flowfield manifests a complex shock wave system and a pair of counter-rotating vortices.
Mechanics of polarization ray tracing (1995)

Polarization ray tracing is a collection of methods that extends geometrical ray tracing allowing the calculation of the evolution of polarization states along ray paths and the determination of the intrinsic polarization properties, such as diattenuation and retardance, associated with ray paths. The suitability of the Jones, Mueller, and threedimensional polarization ray tracing calculi are compared, examining the issues of local versus global coordinates, amplitude versus phase representations, inclusion of the wavefront aberration function, partially polarized light, measurements of images by polarimeters, and diffraction image formation by low- and high-numerical-aperture beams.
Performance of MIMO single-carrier frequency domain zero-forcing equalizer (2012)

Single-carrier frequency domain equalization (SC-FDE) has many advantages, but in the MIMO frequency selective channel its performance has not been fully characterized and several important open questions remain. This paper analyzes the diversity of zero-forcing MIMO SC-FDE. It is shown that the diversity of the ZF receiver over this channel is the same as that of the ZF receiver in the frequency-flat channel. To improve the performance, a lattice-reduction (LR) aided ZF equalization is proposed and analyzed. It is shown that the full spatial and temporal diversity is achieved by he LR-aided ZF receiver for the uncoded transmission. This is the first analytical proof for the LR-aided equalization for MIMO frequency selective channel.
Systems approach to refining genome annotation (2006)

Genome-scale models of Escherichia coli K-12 MG1655 metabolism have been able to predict growth phenotypes in most, but not all, defined growth environments. Here we introduce the use of an optimization-based algorithm that predicts the missing reactions that are required to reconcile computation and experiment when they disagree. The computer-generated hypotheses for missing reactions were verified experimentally in five cases, leading to the functional assignment of eight ORFs (yjjLMN, yeaTU, dctA, idnT, and putP) with two new enzymatic activities and four transport functions. This study thus demonstrates the use of systems analysis to discover metabolic and transport functions and their genetic basis by a combination of experimental and computational approaches.
ChemInform Abstract: Pd(II)‐Mediated Synthesis of 2‐Deoxy‐ and Rare‐C‐glycosides. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A machine‐learning approach to detecting unknown bacterial serovars (2010)

Abstract Technologies for rapid detection of bacterial pathogens are crucial for securing the food supply. A light‐scattering sensor recently developed for real‐time identification of multiple colonies has shown great promise for distinguishing bacteria cultures. The classification approach currently used with this system relies on supervised learning. For accurate classification of bacterial pathogens, the training library should be exhaustive, i.e., should consist of samples of all possible pathogens. Yet, the sheer number of existing bacterial serovars and more importantly the effect of their high mutation rate would not allow for a practical and manageable training. In this study, we propose a Bayesian approach to learning with a nonexhaustive training dataset for automated detection of unknown bacterial serovars, i.e., serovars for which no samples exist in the training library. The main contribution of our work is the Wishart conjugate priors defined over class distributions. This allows us to employ the prior information obtained from known classes to make inferences about unknown classes as well. By this means, we identify new classes of informational value and dynamically update the training dataset with these classes to make it increasingly more representative of the sample population. This results in a classifier with improved predictive performance for future samples. We evaluated our approach on a 28‐class bacteria dataset and also on the benchmark 26‐class letter recognition dataset for further validation. The proposed approach is compared against state‐of‐the‐art involving density‐based approaches and support vector domain description, as well as a recently introduced Bayesian approach based on simulated classes. Copyright © 2010 Wiley Periodicals, Inc. Statistical Analysis and Data Mining 3: 289‐301, 2010
Human feasibility study of hemodynamic monitoring via continuous intrathoracic impedance monitoring (2009)

The ultimate hemodynamic sensor for an implantable device would provide information about cardiovascular performance including systolic function, diastolic function, preload, and afterload. We examined the potential clinical utility of simultaneous measurement of left ventricular pressure and continuous intrathoracic impedance in a group of 20 patients undergoing acute intravenous ablation for atrial fibrillation. Following baseline measurements of traditional left ventricular (LV) conductance volume (control), LV pressure and conductance measurement were repeated using alternate impedance stimulation and sensing vectors that encompassed combinations of the lung, left ventricle, right ventricle and left atrium, respectively. Various relative indices of LV function, including end systolic pressure to volume (conductance) ratio, end diastolic pressure to volume (conductance) ratio, and preload recruitable stroke work (analog) were derived by combining real-time pressure and conductance. The raw morphometry of the LV vector seemed to most closely resemble the gold standard LV conductance volume. For this vector, strong linear correlations between LV pressure and end systolic conductance (r = 0.84 + or - 0.14), end diastolic conductance (r = 0.78 + or - 0.10) and preload recruitable stroke work analog (r = 0.93 + or - 0.05) were observed. The LV vector provides a robust continuous intracardiac hemodynamic signal that may be useful for quantifying cardiovascular function.
Thermoresponsive Chromatographie zur kontinuierlichen Trennung von Proteinen (2012)

Abbildung. Chromatogramm der kontinuierlichen Akkumulation eines Modellproteins im beschriebenen System. Die durchgezogene Linie stellt den Verlauf der Absorption bei 280 nm dar, die acht grauen Rechtecke im Hintergrund markieren
Functions of Heteromeric and Homomeric Isoamylase-Type Starch-Debranching Enzymes in Developing Maize Endosperm (2010)

Functions of isoamylase-type starch-debranching enzyme (ISA) proteins and complexes in maize (Zea mays) endosperm were characterized. Wild-type endosperm contained three high molecular mass ISA complexes resolved by gel permeation chromatography and native-polyacrylamide gel electrophoresis. Two complexes of approximately 400 kD contained both ISA1 and ISA2, and an approximately 300-kD complex contained ISA1 but not ISA2. Novel mutations of sugary1 (su1) and isa2, coding for ISA1 and ISA2, respectively, were used to develop one maize line with ISA1 homomer but lacking heteromeric ISA and a second line with one form of ISA1/ISA2 heteromer but no homomeric enzyme. The mutations were su1-P, which caused an amino acid substitution in ISA1, and isa2-339, which was caused by transposon insertion and conditioned loss of ISA2. In agreement with the protein compositions, all three ISA complexes were missing in an ISA1-null line, whereas only the two higher molecular mass forms were absent in the ISA2-null line. Both su1-P and isa2-339 conditioned near-normal starch characteristics, in contrast to ISA-null lines, indicating that either homomeric or heteromeric ISA is competent for starch biosynthesis. The homomer-only line had smaller, more numerous granules. Thus, a function of heteromeric ISA not compensated for by homomeric enzyme affects granule initiation or growth, which may explain evolutionary selection for ISA2. ISA1 was required for the accumulation of ISA2, which is regulated posttranscriptionally. Quantitative polymerase chain reaction showed that the ISA1 transcript level was elevated in tissues where starch is synthesized and low during starch degradation, whereas ISA2 transcript was relatively abundant during periods of either starch biosynthesis or catabolism.
LSS: A system for production logic synthesis (2000)

For some time we have been exploring methods of transforming functional specifications into hardware implementations that are suitable for production. The complexity of this task and the potential value have continued to grow with the increasing complexity of processor design and the mounting pressure to shorten machine design times. This paper describes the evolution of the Logic Synthesis System from an experimental tool to a production system for the synthesis of masterslice chip implementations. The system was used by one project in IBM Poughkeepsie to produce 90 percent of its more than one hundred chip parts. The primary reasons for this success are the use of local transformations to simplify logic representations at several levels of abstraction, and a highly cooperative effort between logic designers and synthesis system designers to understand the logic design process practiced in Poughkeepsie and to incorporate this knowledge into the synthesis system.
Molecular Exchange between Intra- and Extracellular Compartments in a Cell Suspension (2008)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Ingrid Åslund, Agnieszka Nowacka, Markus Nilsson, Daniel Topgaard; Molecular Exchange between Intra‐ and Extracellular Compartments in a Cell Suspension. AIP Conf. Proc. 5 December 2008; 1081 (1): 79–82. https://doi.org/10.1063/1.3058552 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Location Verification of Wireless Internet Clients: Evaluation and Improvements (2016)

Client Presence Verification (CPV) was proposed in previous literature as a delay-based location verification algorithm that iteratively estimates Internet delays to corroborate assertions about a client's geographic presence in a prescribed region, e.g., before granting access to a location-based service. We evaluate CPV's performance in the presence of clients that use 802.11 networks by analyzing the following factors: the number of such clients in the network, how far adversaries are from their true locations, and the number of CPV iterations required to neutralize the effect of wireless networks. We use a mix of real-world traffic measurements from PlanetLab and existing wireless-delay probability models to create the evaluation datasets. The results indicate that, while wireless delays affect CPV's performance (e.g., from 3 to ~4.7 percent false reject/accept rates), CPV can mitigate the impact of such delays by performing more delay measurements prior to location verification. This work highlights the importance of including mitigation capabilities while designing security-sensitive applications and protocols to deal with the effect of wireless delays. This will become increasingly important with the ubiquitous use of mobile devices that is expected to increase with the introduction of new computing and communication paradigms such as the Internet of Things.
Optimizing queries with materialized views (2002)

While much work has addressed the problem of maintaining materialized views, the important question of optimizing queries in the presence of materialised views has not been resolved. In this paper, we analyze the optimization question and provide a comprehensive and efficient solution. Our solution has the desirable property that it is a simple generalization of the traditional query optimization algorithm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Mammalian promoter element function in the fission yeastSchizosaccharomyces pombe (1992)

We have analyzed the function of several mammalian promoter elements in the fission yeast, Schizosaccharomyces pombe. Mutants of the human HSP70 promoter were introduced into S. pombe as single copy integrants at a specific location. Transcription initiation sites utilized in S. pombe with the HSP70 TATA element were similar to those used in mammalian cells. Of three mammalian TATA elements tested, only the HSP70 TATA element functioned in S. pombe. The adenovirus Ella TATA element had little or no activity in S. pombe, indicating that S. pombe is deficient in the factor(s) necessary for recognition of this element. Of upstream promoter elements tested, the CCAAT, Sp1 binding, ATF binding and heat shock elements were functional in S. pombe. Strains containing mutant promoters fused to the ble gene were used to demonstrate that phleomycin can be used as a graded selection in S. pombe. These data demonstrate that S. pombe should provide a useful system in which to characterize and isolate mammalian factors involved in initiation site determination and transcriptional regulation.
Oxonia-Cope Prins Cyclizations:  A Facile Method for the Synthesis of Tetrahydropyranones Bearing Quaternary Centers (2004)

A new cationic cascade reaction has been developed that produces 4-tetrahydropyranones in good yield. The reaction is based on the facile 2-oxonia Cope rearrangement of allyl-substituted oxocarbenium ions. In the presence of a more nucleophilic silyl enol ether, such systems rearrange and cyclize to produce tetrahydropyranones. The substrates were prepared by silyl ketene acetal addition to ketenes. The rearrangement is compatible with tetrasubstituted silyl enol ethers, which result in the diastereoselective introduction of quaternary centers at the C3 position of the tetrahydropyran ring. The oxonia-Cope Prins rearrangement is a versatile new route to tetrahydropyrans.
Identification of the nucleotide binding site of HIV-1 reverse transcriptase using dTTP as a photoaffinity label (1993)

We have utilized UV-induced cross-linking of [methyl-3H]dTTP to identify the nucleotide binding site on heterodimeric HIV-1 reverse transcriptase (RT). RT was derivatized by irradiating a solution containing [methyl-3H]dTTP and purified recombinant RT for 10 min. The UV-induced cross-linking reaction between dTTP and RT is linear with time of UV exposure up to 10 min, and it has been determined previously that dTTP cross-linking is half-maximal at 90 microM [Cheng, N., Painter, G. R., & Furmann, P.A. (1991) Biochem. Biophys. Res. Commun. 174, 785-789]. Under these reaction conditions, only the 66-kDa subunit of the 66-kDa/51-kDa RT heterodimer was labeled with dTTP. The [methyl-3H]dTTP-labeled RT was fragmented with trypsin and endoproteinase Asp-N, and peptides were purified on reversed phase HPLC. The peptide covalently linked to [methyl-3H]dTTP was subjected to amino acid sequence analysis. The sequencing data localized the nucleotide binding site of RT to Lys-73 in the vicinity of several mutation sites linked to antiviral drug resistance. Since most effective anti-AIDS compounds are inhibitors of RT, information about its dNTP binding site may make it possible to understand the basis for the antiviral activity of nucleoside analogs such as AZT, ddI, and ddC. This information may also be useful for a more rationally based design of anti-HIV agents.
Hydrolysis and Condensation Reactions of Transition Metal Alkoxides: Calorimetric Study and Evaluation of the Extent of Reaction (1998)

The behavior of titanium and zirconium alkoxides towards complexation and water addition is analyzed through water titration and calorimetric experiments. A simple model is presented, which allows evaluation of the mean hydrolysis and condensation constants, Kh and Kc, of both pure and complexed transition metal alkoxides in the sol state, through the analysis of consumed water versus initial hydrolysis ratio curves. These constants allow comparison of the extents of the hydrolysis and condensation reactions for sols obtained from several alkoxide precursors. The complexation ratio only affects the condensation constant Kc, whereas the hydrolysis constant Kh remains unchanged. Analysis of the Kh/Kc ratios has shown that in the sol state, silanol Si–OH groups are more stable than the Ti–OH or Zr–OH groups. Moreover, this study has shown that the proton concentration not only affects the kinetics, but also the final composition of the system. Calorimetric studies of the complexation and hydrolysis/condensation reactions have highlighted the role of coordination unsaturation of the transition metal alkoxides in the exothermicity of these reactions, clearly demonstrating that coordination unsaturation is the driving force behind the reactivity of these alkoxides towards nucleophilic species (e.g. water, complexing ligands, polar solvents).
Some medical applications of acoustic streaming (2005)

Classical acoustic streaming results when an acoustic field is absorbed in a liquid, and the resulting momentum transfer causes the liquid to be translated. Acoustic microstreaming results when a bubble or other compressible entity is caused to oscillate by an acoustic field and hydrodynamic flow is induced in the vicinity of the oscillating surface. Much of the pioneering work on this general topic was performed by Wesley Nyborg and his students at the University of Vermont. There are a number of conditions for which acoustic streaming can be useful in medical ultrasound; e.g., one can enhance diffusion rates of drugs by inducing streaming at a specific site in tissue; together with Doppler imaging, one can determine the consistency of a particular sample of fluid, such as a blood clot. These and other examples of the use of streaming in medical ultrasound will be presented. [Work supported in part by the NIH and NSBRI.]
Vertical Hydrodynamic Focusing and Continuous Acoustofluidic Separation of Particles via Upward Migration (2017)

Abstract A particle suspended in a fluid within a microfluidic channel experiences a direct acoustic radiation force (ARF) when traveling surface acoustic waves (TSAWs) couple with the fluid at the Rayleigh angle, thus producing two components of the ARF. Most SAW‐based microfluidic devices rely on the horizontal component of the ARF to migrate prefocused particles laterally across a microchannel width. Although the magnitude of the vertical component of the ARF is more than twice the magnitude of the horizontal component, it is long ignored due to polydimethylsiloxane (PDMS) microchannel fabrication limitations and difficulties in particle focusing along the vertical direction. In the present work, a single‐layered PDMS microfluidic chip is devised for hydrodynamically focusing particles in the vertical plane while explicitly taking advantage of the horizontal ARF component to slow down the selected particles and the stronger vertical ARF component to push the particles in the upward direction to realize continuous particle separation. The proposed particle separation device offers high‐throughput operation with purity &gt;97% and recovery rate &gt;99%. It is simple in its fabrication and versatile due to the single‐layered microchannel design, combined with vertical hydrodynamic focusing and the use of both the horizontal and vertical components of the ARF.
Monolithic integration of optical neurochip with variable sensitivity photodetector (1993)

A monolithic integration of an optical neurochip with variable interconnection capability is reported. The neurochip is a three-dimensional optoelectronic integrated circuit, in which a variable sensitivity photodetector is directly fabricated on a light emitting diode. The principle of operation and the fundamental characteristics of the monolithic neurochip are described in detail. The optical crosstalk was significantly reduced and the optical coupling efficiency between the light emitting diode and the variable sensitivity photodetector was improved as compared to the previous hybrid structure. The monolithic neurochip is suitable for a large scale integration because there is little optical crosstalk, high efficiency, and no need of optical alignment.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Development of an in vitro system for the study of allergens and allergen‐specific immunoglobulin E and immunoglobulin G: Fcɛ receptor I supercross‐linking is a possible new mechanism of immunoglobulin G‐dependent enhancement of type I allergic reactions (2005)

This assay represents a new tool for the in vitro study of MC activation in response to natural and genetically modified allergens. Fcepsilon receptor I supercross-linking by allergen-specific IgG Abs provides a possible new mechanism of IgG-dependent enhancement of type I allergic reactions.
A novel electron beam-inspection technique for high-impedance contact plugs (2010)

We here present a novel electron beam inspection technique for non-annealed high impedance poly-Si plugs. At this new method, interval time between each electron beam scan is varied to enhance the difference of surface voltage of normal plug, disconnected plug and SiO 2 . Based on experimental results using our experimental tool with the new interval scan technique, contrast between SiO 2 and poly-Si plug, between normal plug and disconnected plug have been dramatically enhanced.