gebhart/patrepeval huggingface dataset:
Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (nN → σ*S–X) Interaction for Conformational Constraint (2015)

The HTS-based discovery and structure-guided optimization of a novel series of GKRP-selective GK-GKRP disrupters are revealed. Diarylmethanesulfonamide hit 6 (hGK-hGKRP IC50 = 1.2 μM) was optimized to lead compound 32 (AMG-0696; hGK-hGKRP IC50 = 0.0038 μM). A stabilizing interaction between a nitrogen atom lone pair and an aromatic sulfur system (nN → σ*S-X) in 32 was exploited to conformationally constrain a biaryl linkage and allow contact with key residues in GKRP. Lead compound 32 was shown to induce GK translocation from the nucleus to the cytoplasm in rats (IHC score = 0; 10 mg/kg po, 6 h) and blood glucose reduction in mice (POC = -45%; 100 mg/kg po, 3 h). X-ray analyses of 32 and several precursors bound to GKRP were also obtained. This novel disrupter of GK-GKRP binding enables further exploration of GKRP as a potential therapeutic target for type II diabetes and highlights the value of exploiting unconventional nonbonded interactions in drug design.
Development of Ontology Building Service ONTOMO Evaluation of Ontology Recommendation Agent Using Proper Noun Extraction (2011)

Ontology-enabled services are rapidly increasing in the Web. However, those are sort of ``lighter'' ontologies compared with ontologies used in design and diagnosis. In this paper, we propose ONTOMO that enables internet users to take part in building those ontologies. ONTOMO is designed not for ontology experts, but for general users of the light-weight ontology. So we focused on easy-use, no installation, and cooperative work environment. Also, it has an agent function which recommends instances and properties belong to ontology classes to boost the users' input. In the recommendation agent, we built our own proper noun extraction mechanism based on bootstrapping. Furthermore, ONTOMO provides a ontology-based blog search as a sample application to motivate the users' ontology building. After the ONTOMO overview, we present the instance and property recommendation agent with experimental evaluation.
3D Printing Laterals for Sand Filters (2022)

Abstract The idea is to use 3D printing technology to design and manufacture wedge wire laterals of sand filters with non-metallic material to withstand the filter operating conditions of treated seawater for oil and gas fields and reservoirs. The design of the laterals is unique and can't be achieved with conventional nonmetallic manufacturing methods due to wedge wire laterals design specifications. This modification will resolve major corrosion challenges, sand migration and meeting water quality specifications in addition to enormous cost savings compare to existing metallic materials. Wedge wire laterals WWL of filters are designed to remove particulates from fluids to prevent contamination, media passing or damage to downstream industrial processes, equipment and oil and gas reservoirs. WWL is the main element for the filtration process and any failure or leaks will lead to media passing and affect to all downstream piping, equipment's and meeting water quality specification. The existing materials is stainless steel 316 and it's has frequent failures, corrosion and pitting even before the T&amp;I due date, as shown in below picture. The design of the laterals is unique and can't be achieved with traditional manufacturing methods of nonmetallic materials due to laterals technical specifications.
Resistive fault current limiters with YBCO films 100 kVA functional model (1999)

Within the Siemens current limiter program a 100 kVA functional model has been realized and tested successfully. According to the modular concept of the limiter the functional model is assembled of ten switching elements. YBCO-films with a thickness of 250 nm and a critical current density above 2/spl times/10/sup 6/ A/cm/sup 2/ are deposited by thermal coevaporation (TU Munich) on 4" sapphire wafers. To support homogeneous switching the superconducting film is covered with a 100 nm Au-shunt layer. Good current limiting performance is achieved: the steady limiting current is below the nominal current, the peak fault current increases up to 3 times the nominal current within an action time of one millisecond. The operational recovery time of the limiter, within which the switching elements return to the superconductive state again is about 2 s. Following our limiter program the next step will be a model device with a nominal switching power of 1 MVA.
Characterizing chemical signaling between engineered “microbial sentinels” in porous microplates (2022)

Living materials combine a material scaffold, that is often porous, with engineered cells that perform sensing, computing, and biosynthetic tasks. Designing such systems is difficult because little is known regarding signaling transport parameters in the material. Here, the development of a porous microplate is presented. Hydrogel barriers between wells have a porosity of 60% and a tortuosity factor of 1.6, allowing molecular diffusion between wells. The permeability of dyes, antibiotics, inducers, and quorum signals between wells were characterized. A "sentinel" strain was constructed by introducing orthogonal sensors into the genome of Escherichia coli MG1655 for IPTG, anhydrotetracycline, L-arabinose, and four quorum signals. The strain's response to inducer diffusion through the wells was quantified up to 14 mm, and quorum and antibacterial signaling were measured over 16 h. Signaling distance is dictated by hydrogel adsorption, quantified using a linear finite element model that yields adsorption coefficients from 0 to 0.1 mol m<sup>-3</sup> . Parameters derived herein will aid the design of living materials for pathogen remediation, computation, and self-organizing biofilms.
Inhibition of nitric oxide synthase augments myocardial contractile responses to beta-adrenergic stimulation (1996)

Recent in vitro evidence suggests a role for nitric oxide (NO) in the modulation of myocardial contractility. The specific role of NO in the control of cardiac function in vivo, however, remains unclear. We investigated the effect of NO synthase (NOS) inhibition on myocardial contractility in response to beta-adrenergic stimulation in autonomically blocked dogs. Intracoronary infusions of dobutamine (1-50 micrograms/min) and isoproterenol (0.1 and 0.5 microgram/min) were performed before and after the intracoronary administration of the specific NOS inhibitor NG-nitro-L-arginine methyl ester (L-NAME). Intracoronary dobutamine resulted in a dose-dependent increase in peak first derivative of pressure (dP/dtmax) to a maximum of 195 +/- 10% (P < 0.001). After inhibition of NOS with intracoronary L-NAME at rates of 0.1 and 1 mg/min, the response to dobutamine was significantly enhanced with dP/dtmax, increasing 276 +/- 17 and 317 +/- 26%, respectively (P < 0.001). Intracoronary isoproterenol resulted in a maximum increase in dP/dtmax of 116 +/- 15% (P < 0.001) that further increased to 154 +/- 17 and 157 +/- 18% after NOS inhibition with 0.1 and 1 mg/min L-NAME, respectively (both P < 0.002). L-NAME had no effect on baseline dP/dtmax but did produce a reduction in myocardial guanosine 3',5'-cyclic monophosphate content. These results suggest a role for NO in the control of myocardial contractility in response to beta-adrenergic stimulation in vivo.
TH2 specific biomarker profile determines steroid responsiveness in severe asthma (2013)

Biomarkers able to determine responsiveness to therapy in severe asthma (SA) are needed. Our goal was to examine the usefulness of periostin, eosinophils and exhaled NO as potential T H 2 specific markers of glucocorticoid responsiveness in SA. Following a 4 week treatment optimization period, patients with SA (n=85) and mild-to-moderate asthma (MA) (n=66) underwent a 2 wk double-blind placebo controlled oral prednisolone (0.5 mg/kg BW daily) intervention (OPI). Serum periostin levels were measured by ELISA using 2 rat anti-human periostin mAbs (clones SS18A & SS17B), (Okamoto et al. ERJ 2011;37:1119). The OPI improved lung function in SA (FEV 1 : 2.28±0.13 L post vs 2.04±0.12 L pre, p Our findings confirm associations between serum periostin levels, eosinophilic inflammation and responsiveness to corticosteroid treatment. Furthermore, we demonstrate that levels of serum periostin are sensitive to oral steroid treatment.
Signalling of multiple interleukin (IL)‐17 family cytokines via IL‐17 receptor A drives psoriasis‐related inflammatory pathways (2021)

Several IL-17 ligands signalling through IL-17RA are overexpressed in psoriasis skin and induce similar psoriasis-related inflammatory pathways demonstrating their relevance in relation to therapeutic intervention in psoriasis.
Combined differential evolution and surface magnetic charge model algorithm for discrimination of UXO from non-UXO items: simple and general inversions (2005)

This paper presents an application of a combined differential evolution (DE) and surface magnetic charge (SMC) model to discriminate objects of interest, such as unexploded ordnance (UXO), from innocuous items. In entire electromagnetic induction (EMI) sensing considered here (tens of Hertz up to several hundreds of kHz), the scattered magnetic field outside the object can be represented in terms of scalar magnetic potential, from which one can obtain all scattered magnetic fields. Such fields are appropriately and readily produced mathematically by equivalent magnetic charges. The amplitudes of these charges are determined from measurement data. The surface magnetic charge model takes into account the scatterer's heterogeneity and near- and far-field effects. It is very fast and simple to implement in EMI inverse scattering algorithms. For simplification of discrimination algorithms, the frequency spectrum of the total normalized equivalent charge is investigated here as a discriminant. Two inversions scenarios are discussed: 1. Simple, when we assume that a buried object's location and orientation are known but its identity is not; and 2. General when both identity and all positional parameters are unknown. In the first case, because the task is only to identify the object, only the SMC model is required and this serves as a test of it alone. In the second case the combined DE and SMC model approach is required for identifying the object as well as its location and orientation. In this case an iterative two-step inversion procedure is used together with measured data. One step calculates an object's location and orientation, and the other calculates the amplitudes of the responding fictitious magnetic charges. Once the object's location, orientation, and spectrum of total magnetic charge are all determined, then that spectrum is compared to cataloged library data for UXO's of interest. To illustrate the applicability of the combined DE and SMC algorithm for UXO discrimination, first a simple inversion methodology is given for an actual UXO and then a general inversion approach is tested for a single object.
Zamknięcie perforacji wolnej ściany lewej komory zatyczką Amplatzer-Muscular VSD Occluder pod kontrolą wewnątrzsercowego badania echokardiograficznego i wideotorakoskopii Closure of left ventricular free wall perforation using the Muscular VSD Occluder under intracardiac echocardiographic and videoscopic control (2005)

Background: In invasive cardiology it is sometimes necessary to use large diameter sheaths. The aim of this study was to assess the precision of monitoring of the percutaneous closure of the left ventricle free wall perforation with the MuscVSDO assisted by intracardiac echocardiography (ICE-AcuNav), intracardiac echocardiography — intravascular ultrasono- graphy IVUS (ICE-Boston Scientific), angiocardiography and videothoracoscopy (VTCS) . Material and methods: The experiment was performed in Centre Hospitalier Universitaire Vaudois, CHUV, Lausanne on 8 pigs. Procedure was controlled with angiocardiography, videothoracoscopy and intracardiac or intravascular ultrasonography. Results: We closed left ventricle free wall perforation by use of the MuscVSDO in all pigs. Conclusion: ICE AcuNav combined with angiocardiography provide sufficient monitoring control during the implantation of the MuscVSDO closing perforation in left ventricle free wall. When the procedure was performed fully percutaneously, videothoracoscopy assistance was necessary to open the pericardium, choose the puncture place, observe the proximal MuscVSDO disc deployment and the bleeding through it. (Folia Cardiol. 2005; 12: 836-841) invasive cardiology, Amplatzer-Muscular VSD Occluder
Novel Effects of Nanoparticulate Delivery of Zinc on Growth, Productivity, and Zinc Biofortification in Maize (Zea mays L.) (2016)

In the present investigation, nanoscale zinc oxide particulates (ZnO-nanoparticulates) were prepared using a modified oxalate decomposition method. Prepared ZnO-nanoparticulates (mean size = 25 nm) were characterized using techniques such as transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), and zeta potential analyzer. Different concentrations (50, 100, 200, 400, 600, 800, 1000, 1500, and 2000 ppm) of ZnO-nanoparticulates were examined to reveal their effects on maize crop on overall growth and translocation of zinc along with bulk ZnSO4 and control. Highest germination percentage (80%) and seedling vigor index (1923.20) were observed at 1500 ppm of ZnO-nanoparticulates. The yield was 42% more compared to control and 15% higher compared to 2000 ppm of ZnSO4. Higher accumulation of zinc (35.96 ppm) in grains was recorded with application of 100 ppm followed by 400 ppm (31.05 ppm) of ZnO-nanoparticulates. These results indicate that ZnO-nanoparticulates have significant effects on growth, yield, and zinc content of maize grains, which is an important feature in terms of human health.
Phosphinidentantal(v)‐Komplexe des Typs [(N3N)TaPR] als Phospha‐Wittig‐Reagentien (R = Ph, Cy, tBu; N3N = (Me3SiNCH2CH2)3N) (1993)

Eine glatte Reaktion mit Aldehyden , wobei Phosphaalkene und der Oxotantal‐Komplex [(N 3 N)TaO] entstehen, gehen die im Titel erwähnten Phosphinidenkomplexe mit nucleophilem Phosphoratom ein. Wie die Struktur von [(N 3 N)TaPR] 1 (R = Cyclohexyl) im Kristall zeigt, befindet sich die reaktive TaPR‐Einheit im Innern einer von den SiMe 3 ‐Substituenten des N 3 N‐Liganden gebildeten Tasche und wird dadurch stabilisiert. magnified image
Community-centric mobile peer-to-peer services: performance evaluation and user studies (2011)

The popularity of social networking services emphasises the importance of user communities. As the next evolutionary step, social networking will evolve towards user communities that are dynamically established according to contextual aspects such as the shared location and/or activities of people. In this vision, distributed peer-to-peer (P2P) technologies provide a respectable alternative to the centralised client-server technologies for implementing the upcoming community-centric mobile services. This thesis focuses on the development of enabling techniques and methods for a communitycentric mobile service environment and on the evaluation of users’ perceptions and user acceptance of novel community-centric mobile services. The research was carried out by first examining the applicability of different P2P system architectures for implementing the management of user communities. Next, an experimental prototype of a community-centric mobile service environment was implemented. The experimental prototype was used for evaluating the performance of the community-centric mobile service environment and for conducting the user studies of novel community-centric mobile services. The evaluation was conducted in a real deployment environment with test users. The main results are the following: (1) a conceptual analysis of the advantages and disadvantages of P2P group management systems that are implemented using architecturally distinct P2P system architectures; (2) a performance evaluation of a P2P community management system, in which each community is implemented as an independent structured P2P overlay network; (3) a novel community-centric mobile service environment and its core component, a mobile middleware, which enables the use of P2P technologies and context information as part of Web-based applications running on a Web browser; (4) an evaluation of users’ perceptions and user acceptance of novel community-centric mobile services that are related to making a selection of an entertainment premise based on its music style and voting for music in a user community.
Environmental Factors Affecting Hydrogen Absorption into Steels (2005)

Environmental factors affecting hydrogen absorption into steels have been investigated by hydrogen permeation tests under atmospheric exposure and simulated environmental conditions. Hydrogen absorption into steels under atmospheric exposure depended upon time in day, seasons and exposure locations. It was confirmed that main environmental factors deciding hydrogen absorption were temperature, humidity and salt concentration by simulated environmental tests. The hydrogen absorption into steels was caused by the hydrolysis accelerated by the combination of Fe3+ ion and Cl- ion in water film on the steel surface. Fe3+ ion which was supplied during corrosion, increased by temperature, humidity and salt on the steels. On the other hand, Cl- concentrated in water film at the lower humidity. The opposite reliability on humidity between the corrosion rate and the Cl- concentration, resulted in the highest hydrogen absorption value in the specific relative humidity range, 50-60%.
Isotope Coded Affinity Tag (ICAT) (2016)

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Epigenetic Mechanisms Underlying the Dynamic Expression of Cancer-Testis Genes, PAGE2, -2B and SPANX-B, during Mesenchymal-to-Epithelial Transition (2014)

Cancer-testis (CT) genes are expressed in various cancers but not in normal tissues other than in cells of the germline. Although DNA demethylation of promoter-proximal CpGs of CT genes is linked to their expression in cancer, the mechanisms leading to demethylation are unknown. To elucidate such mechanisms we chose to study the Caco-2 colorectal cancer cell line during the course of its spontaneous differentiation in vitro, as we found CT genes, in particular PAGE2, -2B and SPANX-B, to be up-regulated during this process. Differentiation of these cells resulted in a mesenchymal-to-epithelial transition (MET) as evidenced by the gain of epithelial markers CDX2, Claudin-4 and E-cadherin, and a concomitant loss of mesenchymal markers Vimentin, Fibronectin-1 and Transgelin. PAGE2 and SPAN-X up-regulation was accompanied by an increase in Ten-eleven translocation-2 (TET2) expression and cytosine 5-hydroxymethylation as well as the disassociation of heterochromatin protein 1 and the polycomb repressive complex 2 protein EZH2 from promoter-proximal regions of these genes. Reversal of differentiation resulted in down-regulation of PAGE2, -2B and SPANX-B, and induction of epithelial-to-mesenchymal transition (EMT) markers, demonstrating the dynamic nature of CT gene regulation in this model.
A 35nm diameter vertical silicon nanowire short-gate tunnelFET (2009)

A top-down integration scheme for silicon vertical nanowire (NW) tunnel field-effect transistors (TFETs) with a 35nm nanowire dimension and using state-of-the-art metal gate and high-k gate dielectric is demonstrated. Using the short-gate concept [1], the ambipolar behavior of the TFET is successfully suppressed. The measured TFET performance is not yet beyond that of the MOSFET, most likely due to the use of silicon that has a large bandgap and the use of ion implantation for the formation of the tunnel junction which results in a low junction abruptness. To boost the device performance, a low thermal budget processing could be used on etched nanowires in a substrate with epitaxial grown junction, in order to increase the abruptness of the tunnel junction.
Engineering Co/MgO interface with heavy metals for voltage-controlled magnetic anisotropy effect (2023)

We have investigated the voltage-controlled magnetic anisotropy (VCMA) effect in Co/MgO junctions by inserting a sub-atomic layer of heavy metals at the interface. We evaluated an electrical control of the magnetic anisotropy by using a micro-magneto-optical Kerr effect magnetometer. The VCMA coefficient of the Co/MgO junctions increases with the insertion of an Ir or Pt layer and decreases with the insertion of an Os layer. These results imply that the VCMA coefficient can be engineered by doping heavy metals at the interface. The interface engineering using a heavy metal layer provides us with a method to control the VCMA coefficient over a wide range.
P‐23: The Contact Properties and TFT Structures of a‐IGZO TFTs Combined with Cu‐Mn Alloy Electrodes (2011)

Abstract Electrical properties and microstructures were investigated between a‐IGZO and metal electrodes. We should use Cu‐Mn or Ti electrodes as the contact promoter and diffusion barrier. Ohmic behaviors were obtained with Cu‐Mn and Ti after annealing at 250 °C. TFT showed high performance with theses. This is due to reduced a‐IGZO and oxygen deficient region.
Manipulating nonlinear optical processes with accelerating light beams (2011)

We show theoretically that accelerating light beams can be used to manipulate nonlinear optical processes through spatiotemporal quasi-phase-matching, allowing for unprecedented temporal and spectral shaping of the generated light. As a proof of principle, we demonstrate exquisite control over the high-order harmonic frequency conversion process, showing efficient enhancement of an extremely broad range of harmonics emitted during a selected quarter-cycle of the driving laser pulse.
Studies directed toward the synthesis of the ingenane diterpenes. An unexpected synthesis of trans-bicyclo[5.3.0]decanes (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies directed toward the synthesis of the ingenane diterpenes. An unexpected synthesis of trans-bicyclo[5.3.0]decanesJeffrey D. Winkler, Elizabeth A. Gretler, and Paul G. WilliardCite this: J. Org. Chem. 1993, 58, 7, 1973–1975Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://pubs.acs.org/doi/10.1021/jo00059a067https://doi.org/10.1021/jo00059a067research-articleACS PublicationsRequest reuse permissionsArticle Views231Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts