gebhart/patrepeval huggingface dataset:
Caenorhabditis elegans AF4/FMR2 family homolog affl-2 is required for heat shock induced gene expression (2019)

Abstract To mitigate the deleterious effects of temperature increases on cellular organization and proteotoxicity, organisms have developed mechanisms to respond to heat stress. In eukaryotes, HSF1 is the master regulator of the heat shock transcriptional response, but the heat shock response pathway is not yet fully understood. From a forward genetic screen for suppressors of heat shock induced gene expression in C. elegans , we identified a new allele of hsf-1 that alters its DNA-binding domain, and three additional alleles of sup-45, a previously uncharacterized genetic locus. We identified sup-45 as one of the two hitherto unknown C. elegans orthologs of the human AF4/FMR2 family proteins, which are involved in regulation of transcriptional elongation rate. We thus renamed sup-45 as affl-2 (AF4/FMR2-Like). affl-2 mutants are egg-laying defective and dumpy, but worms lacking its sole paralog ( affl-1 ) appear wild-type. AFFL-2 is a broadly expressed nuclear protein, and nuclear localization of AFFL-2 is necessary for its role in heat shock response. affl-2 and its paralog are not essential for proper HSF-1 expression and localization after heat shock, which suggests that affl-2 may function downstream or parallel of hsf-1 . Our characterization of affl-2 provides insights into the complex processes of transcriptional elongation and regulating heat shock induced gene expression to protect against heat stress.
<title>Panorama system</title> (1998)

In this paper, we present a panorama system which extends the camera's field of view to the human's one. As the camera's field of view is much smaller than the human's, object could not be captured in a single frame in many cases. To solve this problem a fish-eye lens can be used. However the images obtained in this way have problems in image quality. Another solution is the panorama by frame-aligning and frame-pasting video frames in video sequence. Panorama System gets real time images from the panning video camera and takes align-paste process using registration algorithm. This System can show real time front scene in the human's field of view and can be used in the area-observation application. Experimental results prove the effectiveness and feasibility of the system.
Silicon Photonics Technology Platform for integration of optical IOs with ASICs (2013)

Presents a collection of slides covering the following topics: Silicon Phοtοnics Technology; Optical IO; ASIC; Optical Interconnect; Optical Transceivers; High-Speed Interconnect; and Photonic Interposer.
Dimerization of Resveratrol by the Grapevine Pathogen Botrytis cinerea (1999)

Resveratrol (trans-3,4‘,5-trihydroxystilbene) is produced by grapes (Vitis spp.) in response to microbial attack by the fungal grapevine pathogen Botrytis cinerea. Several reports indicate that pathogenic B. cinerea strains are capable of biotransforming resveratrol into an assortment of unidentified oxidized metabolites as a means of reducing the antifungal effects of resveratrol and facilitating Botrytis invasion into host-plant tissues. Studies utilizing growing incubations of Botrytis cinerea ATCC 11542 with resveratrol resulted in the production of three new (restrytisols A−C) (1−3) and three known (resveratrol trans-dehydrodimer, leachinol F, and pallidol) oxidized resveratrol dimers. All of the metabolites were evaluated for their anti-HIV-1, cytotoxic, and cyclooxygenase (COX) I and COX II inhibitory activities.
Localisation of 15‐hydroxy prostaglandin dehydrogenase (PGDH) and steroidogenic enzymes in the equine placenta (1995)

15-hydroxy prostaglandin dehydrogenase (PGDH) is the critical enzyme that determines metabolism of primary prostaglandins. Its expression is determined in part by steroid hormones, particularly progesterone, formed from delta(5) steroids through 3beta-hydroxysteroid dehydrogenase (3beta-HSD) activity. To assess whether the regulation of PGDH might occur in a paracrine, autocrine or intracrine fashion, we used immunohistochemistry (IHC) to determine the localisation of key steroidogenic enzymes in the equine placenta and compared these patterns to the distribution of immunoreactive (IR-) PGDH. Placental tissue was obtained from pony or Thoroughbred mares at about Days 150, 250-280 and >300 of pregnancy (term 320 to 360 days; n=5-8 each group). IR-PGDH, 3beta-HSD, cholesterol side chain cleavage enzyme (P450(scc)) and 17-hydroxylase/lyase (P450(C17)) were localised using specific antibodies and the avidin-biotin peroxidase technique and visualised using diaminobenzidine as substrate. IR-P450(scc) was present in trophoblast cells, but not in maternal tissues of the microcotyledons. In contrast, at Days 150 and 280, IR-PGDH was present in maternal epithelial and interstitial cells in the microcotyledons, but was not detected in trophoblast epithelium, chorioallantois or endometrial glands. After Day 300, IR-PGDH was present in the maternal epithelium and interstitial cells of the placenta and it was also present in trophoblast cells in some specimens.
Capability Adaptive Elastic IoT Architecture (2015)

IoT networks, together with the data that flows between inter-networked smart devices are growing at unprecedented rates. Storing the data arriving in high volume at IoT gateways or transferring it to back-end clusters for timely processing and real-time response generation is not always feasible, and generally requires considerable overprovisioning of resources. In typical configurations, a computationally capable front-end gateway is available for coordinating the operation of smart devices and for linking them to computation and communication rich back-end infrastructure. It is attractive to harness the computational capabilities in front-end gateways to achieve elasticity of deployment so that the total throughput and response time of IoT solutions can be optimized by intelligent division of labor between devices, front-end gateways, and back-end servers. This paper proposes an Elastic Computing Framework (ECF), an architecture in which programmability of front-end machines is drawn upon to dynamically divide data processing tasks into those that see all of the data but perform simple operations on it, and those that see a transformed subset of the data and extract deep insights from it. This results in lifting the pressure on the network that links the front-and back-ends, and achieves capability adaptive deployment of IoT solutions. In experimental evaluation with one production usage scenario, this approach achieves between six fold and fifty fold reduction in data transferred to back-end clusters, and improves responsiveness by roughly sixteen fold.
257 EXPRESSION OF DEVELOPMENTAL GENES IN PORCINE NUCLEAR TRANSFER EMBRYOS RECONSTRUCTED WITH BONE MARROW MESENCHYMAL STEM CELLS (2005)

Abnormal gene expression is frequently observed in nuclear transfer (NT) embryos and is one of the suggested causes of the low success rates of this approach. Recent study has suggested that adult stem cells may be better donor cells for NT, as their less differentiated state may ease epigenetic reprogramming by the oocyte (Kato et al . 2004 Biol. Reprod. 70, 415-418). In the present study, we investigated the expression profile of some selected genes involved in the development of the pre-implantation embryos of in vivo - and NT-derived origin using bone marrow mesenchymal stem cells (MSCs) and porcine fetal fibroblasts (pFF) as donors. Isolated population of MSCs from porcine bone marrow were characterized by cell-surface antigen profile (CD13pos, CD105pos, CD45neg, and CD133neg) and by their extensive consistent differentiation to multiple mesenchymal lineages (adipocytic, osteocytic and chondrocytic) under controlled in vitro conditions (Pittenger et al . 1999 Science 284, 143-147). Primary cultures of pFF from a female fetus at &amp;lt;30 days of gestation were established. for NT, donor cells at 3-4 passages were employed. Embryos cloned from MSCs showed enhanced developmental potential compared to pFF cloned embryos, indicated by higher rates of blastocyst formation (15.3% ± 4.8 and 9.0% ± 3.9, respectively) and total cell number (31.5 ± 7.2 and 20.5 ± 5.4, respectively) in Day 7 blastocysts. Total RNA was extracted from pools (triplicates) of 10 embryos each of 8-cell, morula, and blastocyst stages of in vivo and NT origin using Dynabeads® mRNA DIRECT" kit (Dynal, Oslo, Norway). Reverse transcription was performed with a Superscript" III cDNA synthesis kit (Invitrogen, Carlsbad, CA, USA). Real-time PCR was performed on a Light cycler® using FastStart DNA Master SYBR Green I (Roche Diagnostics, Mannheim, Germany). The expression profiles of genes involved in transcription (Oct-4, Stat3), DNA methylation (Dnmt1), de novo methylation (Dnmt3a), histone deacetylation (Hdac2), anti-apoptosis (Bcl-xL), and embryonic growth (Igf2r) were determined. The mRNA of H2a was employed to normalize the levels. Significant differences ( P &amp;lt; 0.05) in the relative abundance of Stat3, Dnmt1, Dnmt3a, Bcl2, and Igf2r were observed in pFF NT embryos compared with in vivo -produced embryos, whereas embryos derived from MSCs showed expression patterns similar to those of in vivo -produced embryos. However, Oct-4 and Hdac2 revealed similar expression profiles in NT- and in vivo -produced embryos. These results indicate that MSC-derived NT embryos had enhanced embryonic development and their gene expression pattern more closely resembled that of in vivo -produced embryos. Hence, less differentiated MSCs may have a more flexible potential in improving the efficiency of the porcine NT technique. This work was supported by Grant No. R05-2004-000-10702-0 from KOSEF, Republic of Korea.
“On”/“off” fluorescence intermittency of single semiconductor quantum dots (2001)

Single molecule confocal microscopy is used to investigate the detailed kinetics of fluorescence intermittency in colloidal II–VI (CdSe) semiconductor quantum dots. Two distinct modes of behavior are observed corresponding to (i) sustained “on” episodes (τon) of rapid laser absorption/fluorescence cycling, followed by (ii) sustained “off” episodes (τoff) where essentially no light is emitted despite continuous laser excitation. Both on-time and off-time probability densities follow an inverse power law, P(τon/off)∝1/τon/offm, over more than seven decades in probability density and five decades in time. Such inverse power law behavior is an unambiguous signature of highly distributed kinetics with rates varying over 105-fold, in contrast with models for switching between “on” and “off” configurations of the system via single rate constant processes. The unprecedented dynamic range of the current data permits several kinetic models of fluorescence intermittency to be evaluated at the single molecule level and indicate the importance of fluctuations in the quantum dot environment.
Mono- and Di-Lanthanide Derivatives of 19-Tungsto-2-Arsenate(III) (2010)

Two types of lanthanide-containing derivatives of the 19-tungsto-2-arsenate(III) [As 2 W 19 O 67 - (H 2 O)] 14 − (As 2 W 19 ) have been synthesized in mildly acidic aqueous media and characterized in the solid state. The ytterbium(III)-containing anion [Yb(H 2 O) 2 K(H 2 O) 2 As 2 W 19 O 67 (H 2 O)] 10− (1) was formed by reaction of Yb 3+ with the potassium salt of As 2 W 19 , while the lanthanum(III) derivative [La 2 (H 2 O) 6 As 2 W 19 O 67 (H 2 O)] 8− (2) was formed by reaction of La 3+ with the sodium salt of the trilacunary precursor [B-α-AsW 9 O 33 ] 9− (AsW9). The polyanions 1 and 2 crystallize as hydrated salts in the triclinic system, space group P1̄: K 9.5 Na 0.5 [Yb(H 2 O) 2 K(H 2 O) 2 As 2 W 19 O 67 (H 2 O)]·25H 2 O (KNa-1) with cell dimensions a = 12.4730(5), b = 17.4630(9), c = 21.1990(10) Å, α = 72.568(3) ◦ , β = 85.442(2) ◦ , γ = 89.147(3) ◦ , Z = 2; Na 8 [La 2 (H 2 O) 8 As 2 W 19 O 67 (H 2 O)]·17H 2 O (Na-2) with cell dimensions a = 14.929(2), b = 17.769(3), c = 20.754(4) Å, α = 77.203(10) ◦ , β = 80.273(9) ◦ , γ = 72.670(9) ◦ , Z = 2. Both compounds KNa-1 and Na-2 were characterized in the solid state by FTIR spectroscopy, TGA and single-crystal X-ray diffraction analyses. In polyanion 1, the As 2 W 19 unit sandwiches one ytterbium and one potassium ion leading to a structure with idealized C s symmetry, whereas polyanion 2 incorporates two lanthanum ions leading to a structure with idealized C 2v symmetry. Compositional analogs of polyanions 1 (Ln = La, Ce, Eu, Gd and Lu) and 2 (Ce) were also synthesized and identified by FTIR spectroscopy.
Stereoselective Synthesis of 2-Aminocyclobutanols via Photocyclization of α-Amido Alkylaryl Ketones:  Mechanistic Implications for the Norrish/Yang Reaction (2001)

A series of chiral N-acylated alpha-amino p-methylbutyrophenone derivatives 1a-1h was synthesized from alpha-amino acids via a three-step procedure. These substrates were photolyzed in benzene and gave Norrish II and Norrish I cleavage products as well as the N-acylated 2-aminocyclobutanols that derive from gamma-hydrogen abstraction and 1,4-triplet biradical combination (Yang cyclization). The products were formed with characteristic Yang/cleavage ratios. The quantum yields for the photodecomposition of the N-acetyl-protected substrates 1b,e,f were moderate (12-26%); the diastereoselectivities of the cyclobutanol formation were remarkably high for all substrates. High diastereospecificity was observed for the isoleucine derivatives (2S,3S)-1g and allo-(2S,3R)-1g; the Yang reaction dominated the photochemistry of allo-1g, whereas 1ggave preferentially Norrish II cleavage. The role of hydrogen bonding as one of the stereodirecting effects was demonstrated by comparison of the cyclization efficiency of the valine derivative 1e with 1h,i,j. Also, aromatic beta-keto esters gave the Yang cyclization products in low yields. The diastereoselectivity of the cyclobutanol formation was rationalized by a three-step mechanism where every step is connected with one distinct stereochemical induction mechanism: (a) diastereoselective hydrogen abstraction, (b) conformational equilibration of the 1,4-tetramethylene biradicals (as calculated by semiempiric methods) controlled by hydrogen bonding, and (c) diastereoselective biradical combination (versus cleavage) influenced by spin-orbit coupling controlled intersystem crossing geometries.
Joint deblurring and demosaicking of CFA image data with motion blur (2014)

Camera motion blur is a common problem in low-light imaging applications. It is diffcult to apply image restoration techniques without an accurate blur kernel. Recently, inertial sensors have been successfully utilized to estimate the blur function. However, the effectiveness of these restoration algorithms has been limited by lack of access to unprocessed raw image data obtained directly from the Bayer image sensor. In the work, raw CFA image data is acquired in conjunction with 3-axis acceleration data using a custom-built imaging system. The raw image data records the redistribution of light but is effected by camera motion and the rolling shutter mechanism. Through the use of acceleration data, the spread of light to neighboring pixels can be determined. We propose a new approach to jointly perform deblurring and demosaicking of the raw image. This approach adopts edge-preserving sparse prior in a MAP framework. The improvements brought by our algorithm is demonstrated by processing the data collected from the imaging system.
Visor-projected display using a spherical combiner (1993)

Helmet Mounted Display for daytime missions should have large field of display, as well as undisturbed see-through vision. These requirements naturally lead to the use of the helmet visor as a display combiner. Previous projects were based upon non-spherical, mostly parabolic, tilted combiners. These optical projecting systems suffer from relatively large keystone distortion. This work presents a new optical concept for compensating the distortion, using a spherical surface as an optical combiner coupled to a complementary aberrative relay system.
“No Car Day” (2020)

Transportation is the major factor contributing to climate change. We decided to address the issue of transportation in relation to climate change for this research-informed action (RiA) project. The purpose of our RiA project was to learn about transportation and climate change, conduct a mini-correlational study, and address the issue by encouraging students and their parents to limit car use. After learning that a larger portion of the boys and girls that we surveyed rely on cars to get to school we decided to organize an event called “No Car Day” at Erindale SS on March 22, 2013. This coincided with Earth Hour. In addition, we made announcements from Monday to Thursday to inform student s about this specific event. We counted the number of cars prior to the event and found that an average of 156 cars dropped students off in the morning. On the morning of the event, we counted the number of cars again. This time, the number of cars was 115.We think that our campaign made a difference. We want to encourage students in other schools to organize similar events. We encourage our peers and our teachers to carpool, take the bus, bike or walk. If we all do our part, then we may be able to alleviate the negative effects that transportation has on climate change before it is too late.
ChemInform Abstract: ASYMMETRIC SYNTHESES VIA METALATED CHIRAL HYDRAZONES. OVERALL ENANTIOSELECTIVE α‐ALKYLATION OF ACYCLIC KETONES (1984)

Abstract Die durch Reaktion des Pyrrolidins (I) mit den Ketonen (II) entstandenen Hydrazone (III) reagieren mit den Halogeniden (IV) weiter zu den Hydrazonen (V).
Application of auction results to power system expansion (2002)

Auction results reflect the market condition at the time the auction is performed. The market condition consists not only of electricity demand and supply at that period, but also includes the transmission network condition at that period. The network condition plays a major role in the auction results. If some transmission lines are congested, it can interfere with the desired operation of the network; e.g., block the transaction from the inexpensive sources to the high demand areas. Because of these reasons, an independent contract administrator (ICA) may wish to consider auction results when making decisions related to power system expansion. This work outlines a framework of applying a decision analysis approach to the auction results in selecting the expansion plan for the system.
An evaluation of the clinical impacts of 7‐day platelets (2023)

Platelet transfusions following 7-day storage policy were non-inferior to transfusions in the 5-day policy period, although reduced ACIs were observed. There were no increases in adverse clinical outcomes.
Aging interferes central control mechanism for eccentric muscle contraction (2014)

Previous studies report greater activation in the cortical motor network in controlling eccentric contraction (EC) than concentric contraction (CC) despite lower muscle activation level associated with EC vs. CC in healthy, young individuals. It is unknown, however, whether elderly people exhibiting increased difficulties in performing EC than CC possess this unique cortical control mechanism for EC movements. To address this question, we examined functional magnetic resonance imaging (fMRI) data acquired during EC and CC of the first dorsal interosseous (FDI) muscle in 11 young (20-32 years) and 9 old (67-73 years) individuals. During the fMRI experiment, all subjects performed 20 CC and 20 EC of the right FDI with the same angular distance and velocity. The major findings from the behavioral and fMRI data analysis were that (1) movement stability was poorer in EC than CC in the old but not the young group; (2) similar to previous electrophysiological and fMRI reports, the EC resulted in significantly stronger activation in the motor control network consisting of primary, secondary and association motor cortices than CC in the young and old groups; (3) the biased stronger activation towards EC was significantly greater in the old than the young group especially in the secondary and association cortices such as supplementary and premotor motor areas and anterior cingulate cortex; and (4) in the primary motor and sensory cortices, the biased activation towards EC was significantly greater in the young than the old group. Greater activation in higher-order cortical fields for controlling EC movement by elderly adults may reflect activities in these regions to compensate for aging-related impairments in the ability to control complex EC movements. Our finding is useful for potentially guiding the development of targeted therapies to counteract age-related movement deficits and to prevent injury.
Design of a time reversal mirror for medium scale experiments (2005)

A rigid 24-element acoustic source-receiver array has been jointly developed by ATLANTIDE, LOA and ECA. The array, based on COTS equipment, is specified to be easily deployed from a pier and to allow simple and low cost at sea experiments with water depths up to 20 meters. Dedicated to underwater detection and focusing applications in very shallow water, the instrumentation can be deployed in various acoustic time reversal configurations: detection of drifting objects, acoustic barrier, communication with AUV, etc. The system performance based on the time reversal concept and more particularly on the Time Reversal Operator Decomposition method (D.O.R.T.) is currently being estimated by experiments in a pool and in the bay of Brest.
A Polymorphism in the P2X7 Gene Increases Susceptibility to Extrapulmonary Tuberculosis (2006)

The 1513C allele increases susceptibility to extrapulmonary TB, and this defect is associated with the reduction in the capacity of macrophages to kill M. tuberculosis.
Surface micromachined force gauges: uncertainty and reliability (2001)

Surface micromachining of micro-electro-mechanical systems (MEMS), like all other fabrication processes, has inherent variation that leads to uncertain material and dimensional parameters. By considering the effects of these variations during the design of micro force gauges, the gauge uncertainty and reliability can be estimated. Without the means of calibrating micro gauges, these effects are often significant when compared to experimental repeatability. The general force gauge model described in this paper can be used to measure a wide range of forces, and simple design changes can lead to improved accuracy in measurement. A method of probabilistic design is described that is not limited to small beam deflections.
Multitasking with Play Write, a Mobile Microproductivity Tool (2018)

Mobile devices offer people the opportunity to get useful tasks done during time previously thought to be unusable. Because mobile devices have small screens and are often used in divided attention scenarios, people are limited to using them for short, simple tasks; complex tasks like editing a document present significant challenges in this environment. In this paper we demonstrate how a complex task requiring focused attention can be adapted to the fragmented way people work while mobile by decomposing the task into smaller, simpler microtasks. We introduce Play Write, a microproductivity tool that allows people to edit Word documents from their phones via such microtasks. When participants used Play Write while simultaneously watching a video, we found that they strongly preferred its microtask-based editing approach to the traditional editing experience offered by Mobile Word. Play Write made participants feel more productive and less stressed, and they completed more edits with it. Our findings suggest microproductivity tools like Play Write can help people be productive in divided attention scenarios.