gebhart/patrepeval huggingface dataset:
Measurement of flow harmonics with multi-particle cumulants in Pb+Pb collisions at $\sqrt{s_{NN}}=2.76$ TeV with the ATLAS detector (2014)

ATLAS measurements of the azimuthal anisotropy in lead–lead collisions at $\sqrt{s_{\mathrm {NN}}}=2.76$ TeV are shown using a dataset of approximately 7 $\upmu $ b$^{-1}$ collected at the LHC in 2010. The measurements are performed for charged particles with transverse momenta $0.5<p_{\mathrm {T}}<20$ GeV and in the pseudorapidity range $|\eta |<2.5$ . The anisotropy is characterized by the Fourier coefficients, $\mathrm {v}_n$ , of the charged-particle azimuthal angle distribution for $n = 2$ –4. The Fourier coefficients are evaluated using multi-particle cumulants calculated with the generating function method. Results on the transverse momentum, pseudorapidity and centrality dependence of the $\mathrm {v}_n$ coefficients are presented. The elliptic flow, $\mathrm {v}_2$ , is obtained from the two-, four-, six- and eight-particle cumulants while higher-order coefficients, $\mathrm {v}_3$ and $\mathrm {v}_4$ , are determined with two- and four-particle cumulants. Flow harmonics $\mathrm {v}_n$ measured with four-particle cumulants are significantly reduced compared to the measurement involving two-particle cumulants. A comparison to $\mathrm {v}_n$ measurements obtained using different analysis methods and previously reported by the LHC experiments is also shown. Results of measurements of flow fluctuations evaluated with multi-particle cumulants are shown as a function of transverse momentum and the collision centrality. Models of the initial spatial geometry and its fluctuations fail to describe the flow fluctuations measurements.
[DEMO] Mobile augmented reality — Tracking, mapping and rendering (2014)

In this proposal we suggest a set of demonstrations to be presented at ISMAR 2014 around the topic of monocular tracking, mapping and rendering on mobile phones. We believe that the proposed set of demonstrations will engage ISMAR attendees both in terms of tracking technology and user experience. On the one hand, all demos show state-of-the art tracking and mapping technology and gives attendees a chance to try hands-on our tracking solutions and to discuss them with our researchers and developers. All demos also showcase compelling use cases enabled by our technology, encouraging discussions on topics such as integration of tracking technology with game engines and user experience research.
Submodularity on a tree: Unifying $L^\natural$-convex and bisubmodular functions (2010)

We introduce a new class of functions that can be minimized in polynomial time in the value oracle model. These are functions $f$ satisfying $f(x)+f(y)\ge f(x \sqcap y)+f(x \sqcup y)$ where the domain of each variable $x_i$ corresponds to nodes of a rooted binary tree, and operations $\sqcap,\sqcup$ are defined with respect to this tree. Special cases include previously studied $L^\natural$-convex and bisubmodular functions, which can be obtained with particular choices of trees. We present a polynomial-time algorithm for minimizing functions in the new class. It combines Murota's steepest descent algorithm for $L^\natural$-convex functions with bisubmodular minimization algorithms.
Effects of thermal expansion and degeneracy on ambipolar carrier mobility of non-peripherally hexyl-substituted phthalocyanine (2021)

Abstract The origin of the negative temperature dependence of carrier mobility in a crystal phase of 1,4,8,11,15,18,22,25-octahexylphthalocyanine was studied by utilizing a charge transport simulation based on Marcus theory and density functional theory. In order to understand the unique negative temperature dependence of carrier mobility, the theoretical calculation was carried out by taking the thermal expansion of the lattice parameters into consideration. The calculated hole mobility exhibited the similar temperature dependence as the experimental results. In the electron mobility calculation, the negative temperature dependence could be simulated by considering the degeneracy of lowest unoccupied molecular orbitals as well as the thermal expansion.
Eliminating Structural Loss in Optomechanical Resonators Using Elastic Wave Interference (2014)

Optomechanical resonators suffer from the dissipation of mechanical energy through the necessary anchors enabling the suspension of the structure. Here we show that such structural loss in an optomechnaical oscillator can be almost completely eliminated through the destructive interference of elastic waves using dual-disk resonators. We also present both analytical and numerical model that predicts the observed interference of elastic waves. Our experimental data reveal unstressed SiN devices with mechanical Q-factors up to $10^4$ at mechanical frequencies of $f=102$ MHz ($fQ = 10^{12}$) at room temperature.
A Simple Organocatalytic Enantioselective Cyclopropanation of α,β‐Unsaturated Aldehydes (2007)

Abstract A highly chemo‐ and enantioselective organocatalytic cyclopropanation of α,β‐unsaturated aldehydes with bromomalonate and 2‐bromoacetoacetate esters is presented. The reaction is catalyzed by chiral amines and gives access to 2‐formylcyclopropanes in high yields and up to 99 % ee .
Hard and Soft Capsules: From Branched Polymers to Controlled Release via Gels (2007)

Abstract Summary: Supramolecular gels, made from the combination of telechelic poly (ethyleneglycols) (PEG's) and trivalent poly(isobutylenes) with terminal matching hydrogen bonds were prepared and their rheological properties were investigated. Addition of poly(N‐isopropylacrylamide) as thermosensitive polymer was included into the gel‐capsules in amounts of 10 w%, producing gels with strongly thermally‐ responsive properties. Additionally, dansyl‐dyes with two different endgroups (either an hydrophobic endgroup or a multiple hydrogen bond) were encapsulated into the gels as mimicks for pharmaceutically active substances. Monitoring their diffusion by UV‐dependent measurements allowed to tune the diffusion and thus the release properties of the gel. The generated supramolecular gels will allow the selective encapsulation and triggered release of various pharmaceuticals and biologically active targets.
Fetal movement quantification by fetal vectorcardiography: A preliminary study (2008)

Fetal movement is a valuable source of information to monitor the neurological development of the fetus and assess fetal health. Currently, fetal movement can be assessed by the mother or detected by analysis of ultrasound images. Long-term monitoring of movement is complicated with both these methods as maternal self-assessment has a relatively poor sensitivity and specificity and automatic analysis of ultrasound images is not available. Moreover, ultrasound transducers transmit energy into the body, potentially endangering fetal health. In this paper, an alternative method for fetal movement monitoring is presented. This method operates by estimating and analyzing the fetal vectorcardiogram (VCG) from non-invasive recordings on the maternal abdomen. The determined fetal movement is compared with that assessed from a simultaneously performed ultrasound recording; the results of the presented method are consistent with the ultrasound images. In addition, the presented method enables quantification of the rotation angles by means of analysis of the rotation matrix between consecutive fetal VCGs, providing a tool for long-term monitoring of fetal movement with increased specificity.
Regulation of Polyunsaturated Fatty Acid Biosynthesis by Seaweed Fucoxanthin and Its Metabolite in Cultured Hepatocytes (2013)

The effects of a seaweed carotenoid, fucoxanthin, and its physiological metabolite, fucoxanthinol, on the biosynthesis of polyunsaturated fatty acids (PUFA) were investigated using cultured rat hepatoma BRL-3A. The metabolism of α-linolenic acid (18:3n-3) was suppressed by the addition of these carotenoids, resulting in a decrease in the content of eicosapentaenoic acid (20:5n-3), which suggested a down-regulation of metabolic enzymes such as fatty acid desaturase and elongase. An increase in the content of docosahexaenoic acid (22:6n-3), as observed in previous studies in vivo, might be a buffering action to maintain the membrane fluidity. The suppressive effect of fucoxanthinol on ∆6 fatty acid desaturase was not at the level of gene expression but due to specific modifications of the protein via a ubiquitin-proteasome system. A proteomic analysis revealed several factors such as phosphatidylethanolamine-binding protein that might be involved in the observed action of fucoxanthin. These findings will contribute to studies on the elucidation of the precise molecular mechanisms underlying the regulation of PUFA biosynthesis by fucoxanthin.
A basic bridge information system (2009)

To effectively support bridge asset management practice and aid engineering decisions, many Roading Agencies require a Bridge Information System which is: Easy to use; Cheap to maintain; Robust/reliable/durable; Accessible to a range of users; Flexible and adaptable; Able to readily provide key asset management information; Able to support the bridge management process. Proprietary Bridge Information Systems are available. However these are not always suitable, as they can be: Sophisticated; Require specialist training; Data hungry; User unfriendly; Costly to maintain data; Expensive to purchase, adapt and maintain. To meet Local Authority demand, and a need for an information system to support NZ Transport Agency regional bridge management contracts, a basic Bridge Information System has been developed by Opus, which: Provides basic information suitable for effective bridge management; Supports engineering decision making; Supports the bridge inspection process; Uses a proprietary database system; Is user friendly and readily accessible; Is suitable for both small (less than 50) and large (greater than 1000) bridge stocks; Is adaptable to specific client needs; Is cheap to maintain. This paper outlines the system functionality, how it complements the bridge management process and its key features.
Admittance control for anti-islanding protection in modular grid-connected inverters (2010)

A major requirement for grid-connected power converters imposed by codes and standards is “anti-islanding” protection. When the grid connection is lost or otherwise stops functioning, the photovoltaic power converter is required to shut off to avoid “backfeed” into the local distribution network. This paper describes a “reverse PFC” admittance control that controls the output current of an inverter in response to a detected grid voltage. It is shown that loss of grid will drive the inverter voltage to zero except in a unique special case. The special case can still be detected if the admittance includes a slow phase variation.
Communication vs distributed computation: An alternative trade-off curve (2017)

In this paper, we revisit the communication vs. distributed computing trade-off, studied within the framework of MapReduce in [1]. An implicit assumption in the aforementioned work is that each server performs all possible computations on all the files stored in its memory. Our starting observation is that, if servers can compute only the intermediate values they need, then storage constraints do not directly imply computation constraints. We examine how this affects the communication-computation trade-off and suggest that the trade-off be studied with a predetermined storage constraint. We then proceed to examine the case where servers need to perform computationally intensive tasks, and may not have sufficient time to perform all computations required by the scheme in [1]. Given a threshold that limits the computational load, we derive a lower bound on the associated communication load, and propose a heuristic scheme that achieves in some cases the lower bound.
Generation and functional characterization of a multigene-modified NK101 cell line exerting diverse mechanisms of antitumor action (2022)

Clonal cell line-based, multigene-modified, off-the-shelf NK cell therapeutics are emerging as the new frontier of adoptive cellular immunotherapy. Here, we utilized a newly established NK cell line, NK101, as a backbone to derive multifaceted killer cells armored with various antitumor modalities through repeated cycles of genetic modification and clonal selection. First, NK101 cells were transduced with a tricistronic lentiviral vector expressing CD7, CD28, and cytosine deaminase (CD). The resulting cell line demonstrated enhanced cytotoxicity against B7<sup>+</sup> tumors and exerted bystander killing effects on neighboring tumor cells upon 5-FC treatment. Second, engineered NK101 cells were again transduced with a bicistronic vector expressing membrane-bound interleukin-15 (mbIL-15) and dominant negative TGFβ type II receptor (DNTβRII). Ectopic expression of mbIL-15 resulted in further augmentation of lytic activities against all tested target cells by inducing upregulation of multiple activating receptors, while that of DNTβRII allowed the cells to maintain heightened cytotoxicity in the presence of TGFβ. Finally, dual-transduced NK101 cells were modified to express chimeric antigen receptors (CARs) targeting either a solid tumor antigen (EpCAM) or a hematologic tumor antigen (FLT3). The final engineered products not only demonstrated antigen-specific killing activities in vitro but also exerted strong tumor-inhibitory effects in preclinical models of metastatic solid tumor and hematologic malignancy. Notably, combined treatment with 5-FC further enhanced antitumor efficacy of engineered NK101 in the solid tumor model. Our results demonstrate successful generation of multigene-modified NK101 cell therapeutics exerting diverse mechanisms of antitumor action - activation receptor-mediated innate killing, antigen-specific killing, and bystander effect-mediated killing.
Chiral α-P,N Ligands From a Diastereoselective Ph2PH Addition to (η6-Benzaldimine)tricarbonylchromium Complexes (1999)

HAL is
High quality normal map compression (2006)

Normal mapping is a widely used technique in real-time graphics, but so far little research has focused on compressing normal maps. Therefore, we present several simple techniques that improve the quality of ATI's 3Dc normal map compression algorithm. We use varying point distributions, rotation, and differential encoding. On average, this improves the peak-signal-to-noise-ratio by 3 dB, which is clearly visible in rendered images. Our algorithm also allows us to better handle slowly varying normals, which often occurs in real-world normal maps. We also describe the decoding process in detail.
A Review of Anomaly Detection on Graphs (2008)

Anomaly detection on graphs of social or communication networks has important security applications. The definition of a graph anomaly typically depends on the data and application of interest. Usually central in anomaly detection are the connections amongst the graph's entries and various methods have been developed for their analysis. We review these techniques and also discuss challenges currently faced for high-dimensional dynamic graphs.
Effects of epigenetic modulation on reporter gene expression: implications for stem cell imaging (2005)

Tracking stem cell localization, survival, differentiation, and proliferation after transplantation in living subjects is essential for understanding stem cell biology and physiology. In this study, we investigated the long-term stability of reporter gene expression in an embryonic rat cardiomyoblast cell line and the role of epigenetic modulation on reversing reporter gene silencing. Cells were stably transfected with plasmids carrying cytomegalovirus promoter driving firefly luciferase reporter gene (CMV-Fluc) and passaged repeatedly for 3-8 months. Within the highest expressor clone, the firefly luciferase activity decreased progressively from passage 1 (843+/-28) to passage 20 (250+/-10) to passage 40 (44+/-3) to passage 60 (3+/-1 RLU/microg; P<0.05 vs. passage 1). Firefly luciferase activity was maximally rescued by treatment with 5-azacytidine (DNA methyltransferase inhibitor) compared with trichostatin A (histone deacetylase inhibitor) and retinoic acid (transcriptional activator; P<0.05). Increasing dosages of 5-azacytidine treatment led to higher levels of firefly luciferase mRNA (RT-PCR) and protein (Western blots) and inversely lower levels of methylation in the CMV promoter (DNA nucleotide sequence). These in vitro results were extended to in vivo bioluminescence imaging (BLI) of cell transplant in living animals. Cells treated with 5-azacytidine were monitored for 2 wk compared with 1 wk for untreated cells (P<0.05). These findings should have important implications for reporter gene-based imaging of stem cell transplantation.
47. Long Term Outcomes of Pulse-taper Corticosteroid Therapy (PCT) for Refractory Non-HIV Cryptococcal Meningoencephalitis (2020)

Abstract Background Cryptococcal meningoencephalitis (CM) is a major cause of mortality in HIV/AIDS, transplant recipients and previously healthy individuals. In the latter, a post-infectious inflammatory response syndrome (PIIRS) is associated with poor clinical response despite prior amphotericin therapy and CSF culture conversion. Data on effective treatment is limited. Methods Between March 2015 and March 2020, 15 patients with CM/PIIRS were treated with adjunctive pulse – taper corticosteroid therapy (PCT) consisting of intravenous methylprednisolone 1 gm daily for 1 week followed by oral prednisone 1 mg/kg/d, tapered based on clinical and radiological response plus oral fluconazole. Montreal cognitive assessments (MOCA), Karnofsky Performance scores, MRI brain scans, eye and audiologic exams were conducted at baseline and after pulse completion. CSF parameters were assessed prior to and after the pulse. Results 80% of patients were male, median age 51 years. Median time from antifungal treatment to steroid initiation was 6 weeks. The most common symptoms at PIIRS diagnosis were progressive deterioration in mental status and vision changes. There was a significant improvement in MOCA(n=14) and Karnofsky(n=15) scores at 3 weeks (p&amp;lt; 0.0003), which was accompanied by improvements in CSF: serum, glucose ratios, CSF WBC, protein and activated CD4 T cells (n=14) post-pulse (p&amp;lt; 0.003). Additionally, soluble CSF IL-6 and sCD25 levels improved (p = 0.03). Neurofilament light chain levels (NFL), a biomarker of axonal damage, showed significant reductions over a 30-month period (Generalized Estimating Equation coefficient = 0.128) and a negative correlation with post pulse MOCA scores (r = - 0.8; p = 0.01). Papilledema (n=8) and visual field deficits (n=11) improved significantly (p&amp;lt; 0.0005) after 2 months of pulse completion. Brain MRI showed improvement of radiological findings in 11 patients (p=0.001). Five out of 7 patients who underwent audiological testing demonstrated hearing improvement after 3 weeks post-pulse. CSF cultures remained negative. Conclusion PCT in this small cohort of PIIRS patients was associated with persistent improvements in CM-related complications with minimal toxicity and no recurrence of infection. Disclosures All Authors: No reported disclosures
Immobilization of aptamers onto unmodified glass surfaces for affordable biosensors (2011)

Silicon dioxide surfaces are commonly used in photonic microsensors for bioreceptor attachment. Functionalization of sensor surface with aptamer receptors provides the opportunity to develop low cost, robust, field deployable sensors. Most aptamer sensors are constructed by covalently linking modified aptamers to a derivatized surface. There have been reports of using UV crosslinking to directly immobilize DNA with sequences that end with poly(T)10-poly(C)10 on an unmodified glass surface for hybridization. We have expanded this strategy using thrombin-binding aptamers (TBAs) with three different tail modifications. TBA with PolyT20 tail showed the best performance in terms of sensitivity and dynamic range. PolyTC tailed aptamers did not bind thrombin well, which may be due to that the interactions between the C bases and G-quadruplex affect their target binding capability. When compared to biotinylated aptamer immobilized on a streptavidin surface, polyT aptamer printed directly on plain glass showed comparable affinity. Direct immobilization of TBA on nonfunctionalized silicon dioxide wafer and its binding towards thrombin has also been demonstrated. Our results showed that using polyT-tagged aptamer probes directly immobilized on unmodified glass and SiO<sub>2</sub> surface is a robust, very straightforward, and inexpensive method for preparing biosensors.
Competitive Adsorption of Thiolated Polyethylene Glycol and Mercaptopropionic Acid on Gold Nanoparticles Measured by Physical Characterization Methods (2010)

Competitive adsorption kinetics between thiolated polyethylene glycol (SH-PEG) and mercaptopropionic acid (MPA) on gold nanoparticles (Au-NPs) were studied using a prototype physical characterization approach that combines dynamic light scattering (DLS) and electrospray differential mobility analysis (ES-DMA). The change in hydrodynamic particle size (intensity average) due to the formation of SH-PEG coatings on Au-NPs was measured by DLS in both two-component (Au-NP + MPA or Au-NP + SH-PEG) and three-component (Au-NP +MPA + SH-PEG) systems. ES-DMA was employed to quantify the surface coverage of SH-PEG and establish a correlation between surface coverage and the change in particle size measured by DLS. A change in the equilibrium binding constant for SH-PEG on Au-NPs at various concentrations of SH-PEG and MPA showed that the presence of MPA reduced the binding affinity of SH-PEG to the Au-NP surface. Kinetic studies showed that SH-PEG was desorbed from the Au-NP surface following a second-order desorption model after subsequently introducing MPA. The desorption rate constant of SH-PEG from the Au-NP surface by MPA displacement was strongly affected by the concentration of MPA and the excess SH-PEG in solution.
Efficient exploitation of kernel access to Infiniband: a software DSM example (2004)

The Infiniband (IB) system area network (SAN) enables applications to access hardware directly from the user level, reducing the overhead of user-kernel crossings during data transfer. However, distributed applications that exhibit close coupling between network and OS services may benefit from accessing IB from the kernel through IB's native verbs interface, which permits tight integration of these services. We assess this approach using a sequential-consistency distributed shared memory (DSM) system as an example. We first develop primitives that abstract the low-level communication and kernel details, and efficiently serve the application's communication, memory,and scheduling needs. Next, we combine the primitives to form a kernel DSM protocol. The approach is evaluated using our full-fledged Linux kernel DSM implementation over Infiniband.