gebhart/patrepeval huggingface dataset:
ChemInform Abstract: SWAZIN, EIN NEUES ALKALOID AUS SENECIO SWAZIENSIS COMPTON, EINE CHEMISCHE UND ROENTGENANALYSE EINES NEUEN SPIRODILACTONS (1972)

Abstract Aus Swazin (I) entstehen beim Abbau Retronecin (II) und ein neues Spirodilacton (III), dessen Struktur aufgeklärt wird.
Identification of residues within the African swine fever virus DP71L protein required for dephosphorylation of translation initiation factor eIF2α and inhibiting activation of pro-apoptotic CHOP (2017)

The African swine fever virus DP71L protein recruits protein phosphatase 1 (PP1) to dephosphorylate the translation initiation factor 2α (eIF2α) and avoid shut-off of global protein synthesis and downstream activation of the pro-apoptotic factor CHOP. Residues V16 and F18A were critical for binding of DP71L to PP1. Mutation of this PP1 binding motif or deletion of residues between 52 and 66 reduced the ability of DP71L to cause dephosphorylation of eIF2α and inhibit CHOP induction. The residues LSAVL, between 57 and 61, were also required. PP1 was co-precipitated with wild type DP71L and the mutant lacking residues 52- 66 or the LSAVL motif, but not with the PP1 binding motif mutant. The residues in the LSAVL motif play a critical role in DP71L function but do not interfere with binding to PP1. Instead we propose these residues are important for DP71L binding to eIF2α.
Hochauflösende in vitro Proben- und in vivo Kleintierbildgebung mit dedizierten Solenoid-Spulen in einem klinischen 3T MRT (2008)

Ziele: Evaluation der Bildgebungseigenschaften von zwei neuen Empfängerspulen in-vitro an Proben-Phantomen sowie in vivo an Kleintieren in einem klinischen 3T Ganzkörper-MRT bei 3T. Methode: Zwei Kleintier-1-Kanal RF Solenoid-Spulen (Rattenspule (RC): 7cm Ø, 10cm Länge; Mausspule (MC): 4cm Ø, 9cm Länge, Philips Forschungslaboratorien, Deutschland) wurden in einem klinischen 3T Ganzkörper-MRT (Philips Intera, Niederlande) getestet. SNR, transversale und longitudinale Spulenhomogenität sowie Bildqualität wurden unter Anwendung typischer 2D und 3D Sequenzprotokolle (T1w SE, T2w TSE, T2*w FFE, Voxeldimensionen 500–70µm3) in vitro an verschiedenen Probenphantomen (zylindrische Wasser-Phantome, Gelphantome SPIO-markierter Stammzellen (MSC-SPIO) und Antikörper(AK)-gekoppelter SPIO Konjugate auf Zelloberflächen-Rezeptoren von Tumorzellen), sowie ex vivo und in vivo an Kleintieren (Ratten (RC), Mäuse (MC)) analysiert. Ergebnis: Die Signalprofile der in vitro Wasserphantome zeigten ein hohes und nahezu homogenes SNR in transversaler Orientierung in beiden Spulensystemen (Signalvariation: ~13% für RC, ~7% für MC) sowie in longitudinaler Richtung auf einer Länge von >4cm (MC) bzw. >6cm (RC). Die SNR Messungen zeigten ein ~3fach besseres SNR in der Mausspule im Vgl. zur Rattenspule (z.B. SNR-MC(T2w): 50, SNR-RC(T2w): 17). Eine in vitro Einzelzellbildgebung (T2*w) von MSCSPIO war in beiden Spulensystemen bis zu einer Auflösung <100µm3 bei akzeptablen Akquisitionszeiten (<10 Min.) möglich. Eine Bindung spezifischer AK-SPIO Konjugate auf Zelloberflächen-Rezeptoren von in Gelantine eingebetteten Tumorzellen (107 Zellen/ml) war detektierbar. Eine hochauflösende Kleintierbildgebung (<200µm3) war sowohl ex vivo als auch in vivo mit akkurater Abbildung von anatomischen Strukturen (Wirbelsäule, Oberbauchorgane, Nieren) sowie deren intraparenchymatöser Gefäßstrukturen mit exzellentem SNR (SNR-MC(T2w)≥30) bei kurzen Akquisitionszeiten (<5 Min.) durchführbar. Schlussfolgerung: Die Kombination aus homogenem Signalverhalten und hohem Signal-zu-Rausch-Verhältnis der zwei getesteten Kleintier-Spulensysteme ermöglicht sowohl eine hochauflösende in vitro Bildgebung von Proben- und Zellphantomen als auch detaillierte in vivo Kleintierbildgebung von Ratten und Mäusen in einem klinischen 3T MR Gerät.
Location of antigenic sites recognized by monoclonal antibodies in the influenza A virus nucleoprotein molecule (2009)

The locations of amino acid positions relevant to antigenic variation in the nucleoprotein (NP) of influenza virus are not conclusively known. We analysed the antigenic structure of influenza A virus NP by introducing site-specific mutations at amino acid positions presumed to be relevant for the differentiation of strain differences by anti-NP monoclonal antibodies. Mutant proteins were expressed in a prokaryotic system and analysed by performing ELISA with monoclonal antibodies. Four amino acid residues were found to determine four different antibody-binding sites. When mapped in a 3D X-ray model of NP, the four antigenically relevant amino acid positions were found to be located in separate physical sites of the NP molecule.
Teaching Manipulator Kinematics by Painting With Light (2011)

In this paper, we examine the creation and benefits of a new teaching platform to introduce and reinforce the key concepts of robotic manipulators in an introductory-level robotics course. This system combines a vintage PUMA 260 six-degree-of-freedom robotic arm with modern control circuitry and a Matlab API. The API operates as a servo controller for the robot, thereby allowing students to apply their knowledge of inverse kinematics to a real manipulator arm. To further motivate the exploration of manipulators, we have developed an open-ended project where students engage in the art of three-dimensional light painting. To facilitate this activity, a tricolor LED has been affixed to the end-effector of the robot. With a digital SLR camera, we take a long-exposure photograph as the robot is driven through a trajectory, effectively painting a picture with the end effector. We have also developed a method to quickly assemble pseudo-long-exposure photographs and videos using an inexpensive video camera. We believe this novel setup and project are an effective way to engage and motivate students to learn the underlying math and dynamics of robotic manipulators.
Esophageal stent placement as a therapeutic option for iatrogenic esophageal perforation in children (2016)

Iatrogenic esophageal perforation (IEP) is a potentially serious adverse event of interventional endoscopy. The approach to IEP varies from surgical repair for large perforations to conservative treatment for small contained perforations. We report a case of an 18-month-old girl with congenital esophageal stenosis suffering a large esophageal perforation after a trial of stricture dilatation, which was successfully managed by the placement of fully covered stent. Hence, in selected cases, esophageal stent placement is a feasible alternative to invasive surgery in managing IEP.
Stepwise Reduction of Dinitrogen to Nitride Assisted by Niobium Bonded to Oxygen Donor Atoms:  The Potential of Reduced Forms of Niobium Calix[4]arene (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTStepwise Reduction of Dinitrogen to Nitride Assisted by Niobium Bonded to Oxygen Donor Atoms: The Potential of Reduced Forms of Niobium Calix[4]areneAntonio Zanotti-Gerosa, Euro Solari, Luca Giannini, Carlo Floriani, Angiola Chiesi-Villa, and Corrado RizzoliView Author Information Institut de Chimie Minérale et Analytique, BCH Université de Lausanne CH-1015 Lausanne, Switzerland Dipartimento di Chimica, Università di Parma I-43100 Parma, Italy Cite this: J. Am. Chem. Soc. 1998, 120, 2, 437–438Publication Date (Web):January 1, 1998Publication History Received8 July 1997Published online1 January 1998Published inissue 1 January 1998https://pubs.acs.org/doi/10.1021/ja9722584https://doi.org/10.1021/ja9722584rapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views859Altmetric-Citations118LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Nitrides,Nitrogen,Oligomers,Redox reactions,Transition metals Get e-Alerts
331 Modeling of Pneumatic Artificial Actuator and Joint Control (2008)

Recently, research has concentrated on pneumatic robot hand. Here, we develop a pneumatic actuator driven by low pressure. We develop a five-fingered robot hand by using the pneumatic actuator, and we construct a master-slave system to enable the robot hand to perform the same operations as a human hand. Next, a 1-link arm is made, which has one degree of freedom using the pneumatic actuators, and the models of actuator and 1-link arm is constructed. We construct a control system for the 1-link arm and verify its control performance.
Specific T-Cell Epitopes for Immunoassay-Based Diagnosis ofMycobacterium tuberculosisInfection (2004)

ABSTRACT The currently used method for immunological detection of tuberculosis infection, the tuberculin skin test, has low specificity. Antigens specific for Mycobacterium tuberculosis to replace purified protein derivative are therefore urgently needed. We have performed a rigorous assessment of the diagnostic potential of four recently identified antigens (Rv2653, Rv2654, Rv3873, and Rv3878) from genomic regions that are lacking from the Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccine strains as well as from the most common nontuberculous mycobacteria. The fine specificity of potential epitopes in these molecules was evaluated by sensitive testing of the T-cell responses of peripheral blood mononuclear cells derived from M. bovis BCG-vaccinated healthy individuals to synthesized overlapping peptides. Three of the four molecules contained regions with significant specificity problems (Rv2653, Rv3873, and Rv3878). We selected and combined the specific peptide stretches from the four proteins not recognized by M. bovis BCG-vaccinated individuals. These peptide stretches were tested with peripheral blood mononuclear cells obtained from patients with microscopy- or culture-confirmed tuberculosis and from healthy M. bovis BCG-vaccinated controls. The combination of the most promising stretches from this analysis showed a sensitivity level (57%) comparable to the level found with the two well-known M. tuberculosis -specific proteins ESAT-6 and CFP-10 (75 and 66%, respectively). The combination of ESAT-6, CFP-10, and the novel specific peptide stretches gave an overall sensitivity of 84% at a specificity of 97%. In a validation experiment with new experimental groups, the sensitivities obtained were 57% for the combination of peptides and 90% for the combination of the peptides, ESAT-6, and CFP-10. This combination gave a specificity of 95%.
Sufficient conditions for sound tree hashing modes (2009)

We consider the general case of tree hashing modes that make use of an underlying compression function. We consider such a tree hashing mode sound if differentiating it from a random oracle, assuming the underlying compression function is a random oracle can be proven to be hard. We demonstrate two properties that such a tree hashing mode must have for such a proof to exist. For each of the two properties we show that several solutions exist to realize them. For some given solutions we demonstrate that a simple proof of indifferentiability exists and obtain an upper bound on the differentiability probability of $q^2/2^n$ with $q$ the number of queries to the underlying compression function and $n$ its output length. Finally we give two examples of hashing modes for which this proof applies: KeccakTree and Prefix-free Merkle-Damgard.
Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene. (1996)

Arg and c-Abl represent the mammalian members of the Abelson family of nonreceptor protein-tyrosine kinases. To gain insight into the biological role of Arg we used the two-hybrid approach to identify interacting proteins. Using a C-terminal segment of Arg we identified a novel protein, ArgBP1 (Arg binding protein 1). ArgBP1 contains a C-terminal SH3 domain, several PEST sequences, a serine rich domain and an SH3 binding site. ArgBP1 is ubiquitously expressed as two transcripts of approximately 2.2 kb and approximately 8 kb with highest levels in brain, heart and testis. The association of ArgBP1 with Arg in living cells was confirmed by coimmunoprecipitation in cotransfected COS cells. Analysis of the mechanism of association indicated that the ArgBP1 SH3 domain binds to a C-terminal Arg SH3-binding site, and that an N-terminal ArgBP1 proline-rich sequence binds to the Arg SH3 domain. Immunostaining indicated that the subcellular localization of ArgBP1 is cytoplasmic. The similarity of the ArgBP1 expression pattern and subcellular localization to those of Arg and the potential for a highly specific and potentially strong association mediated by two pairs of SH3 domain/proline-rich motif interactions, suggest that ArgBP1 is likely to be a regulator and/or effector of Arg function.
Risk-factors of melphalan/fludarabine dose-reduced allogeneic stem cell transplantation in patients with multiple myeloma (2004)

To evaluate the impact of timing of dose-reduced allograft in patients with multiple myeloma, we analyzed 120 patients in a retrospective study, who were treated with melphalan/fludarabine as conditioning regimen. The cumulative risk at one year for treatment-related mortality (TRM) was 18% (95% CI: 12–28%). In a multivariate analysis, relapse after prior high-dose chemotherapy was the most significant factor for TRM (HR 2.80; 95% CI: 1.16–6.74; p = 0.02), relapse (HR 4.14; 95% CI: 2.04–8.38, p < 0.001), event-free (HR 3.11; 95% CI: 1.77–5.46; p < 0.001), and overall survival (HR 2.69; 95% CI: 1.35–5.35; p = 0.005). In addition, relapse was also significantly diminished by chronic GvHD in a time-dependent Cox model (HR 0.37; 95% CI: 0.16–0.87; p = 0.02), while trans-plantation with peripheral blood stem cells (PBSC) resulted in better overall survival (HR 0.35; 95% CI: 0.14–0.88; p = 0.002). In a subgroup of patients with chemosensitivity at time of transplantation and no relapse after a prior high-dose chemotherapy who were transplanted with PBSC (n = 46), the cumulative risk of TRM at one year was only 8% (95% CI: 1–54%), and the two-year estimated event-free and overall survival was 60% (95% CI: 42–78%) and 75% (95% CI: 59–91%) for related (n = 34), and 81% (95% CI: 59–100%) and 92% (95% CI: 76–100%) for unrelated donors (n = 12). We conclude that dose-reduced allograft with related and unrelated donors should be performed at an earlier stage of the disease in patients who are chemosensitive and without relapse after a prior autograft, resulting in a lower TRM and better event-free and overall survival.
Synthesis of 3-fluorodiaminopimelic acid isomers as inhibitors of diaminopimelate epimerase: stereocontrolled enzymatic elimination of hydrogen fluoride (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 3-fluorodiaminopimelic acid isomers as inhibitors of diaminopimelate epimerase: stereocontrolled enzymatic elimination of hydrogen fluorideMichael H. Gelb, Yukang Lin, Michael A. Pickard, Yonghong Song, and John C. VederasCite this: J. Am. Chem. Soc. 1990, 112, 12, 4932–4942Publication Date (Print):June 1, 1990Publication History Published online1 May 2002Published inissue 1 June 1990https://pubs.acs.org/doi/10.1021/ja00168a045https://doi.org/10.1021/ja00168a045research-articleACS PublicationsRequest reuse permissionsArticle Views386Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Integrated Reflection Seismic Monitoring and Reservoir Modeling for Geologic CO<sub>2</sub> Sequestration (2012)

The US DOE/NETL CCS MVA program funded a project with Fusion Petroleum Technologies Inc. (now SIGMA) to model the proof of concept of using sparse seismic data in the monitoring of CO{sub 2} injected into saline aquifers. The goal of the project was to develop and demonstrate an active source reflection seismic imaging strategy based on deployment of spatially sparse surface seismic arrays. The primary objective was to test the feasibility of sparse seismic array systems to monitor the CO{sub 2} plume migration injected into deep saline aquifers. The USDOE/RMOTC Teapot Dome (Wyoming) 3D seismic and reservoir data targeting the Crow Mountain formation was used as a realistic proxy to evaluate the feasibility of the proposed methodology. Though the RMOTC field has been well studied, the Crow Mountain as a saline aquifer has not been studied previously as a CO{sub 2} sequestration (storage) candidate reservoir. A full reprocessing of the seismic data from field tapes that included prestack time migration (PSTM) followed by prestack depth migration (PSDM) was performed. A baseline reservoir model was generated from the new imaging results that characterized the faults and horizon surfaces of the Crow Mountain reservoir. The 3D interpretation was integrated with the petrophysical data from available wells and incorporated into a geocellular model. The reservoir structure used in the geocellular model was developed using advanced inversion technologies including Fusion's ThinMAN{trademark} broadband spectral inversion. Seal failure risk was assessed using Fusion's proprietary GEOPRESS{trademark} pore pressure and fracture pressure prediction technology. CO{sub 2} injection was simulated into the Crow Mountain with a commercial reservoir simulator. Approximately 1.2MM tons of CO{sub 2} was simulated to be injected into the Crow Mountain reservoir over 30 years and subsequently let 'soak' in the reservoir for 970 years. The relatively small plume developed from this injection was observed migrating due to gravity to the apexes of the double anticline in the Crow Mountain reservoir of the Teapot dome. Four models were generated from the reservoir simulation task of the project which included three saturation models representing snapshots at different times during and after simulated CO{sub 2} injection and a fully saturated CO{sub 2} fluid substitution model. The saturation models were used along with a Gassmann fluid substitution model for CO{sub 2} to perform fluid volumetric substitution in the Crow Mountain formation. The fluid substitution resulted in a velocity and density model for the 3D volume at each saturation condition that was used to generate a synthetic seismic survey. FPTI's (Fusion Petroleum Technologies Inc.) proprietary SeisModelPRO{trademark} full acoustic wave equation software was used to simulate acquisition of a 3D seismic survey on the four models over a subset of the field area. The simulated acquisition area included the injection wells and the majority of the simulated plume area.
Quantified reading and learning for sharing experiences (2017)

This paper presents two topics. The first is an overview of our recently started project called "experiential supplement", which is to transfer human experiences by recording and processing them to be acceptable by others. The second is sensing technologies for producing experiential supplements in the context of learning. Because a basic activity of learning is reading, we also deal with sensing of reading. Methods for quantifying the reading in terms of the number of read words, the period of reading, type of read documents, identifying read words are shown with experimental results. As for learning, we propose methods for estimating the English ability, confidence in answers to English questions, and estimating unknown words. The above are sensed by various sensors including eye trackers, EOG, EEG, and the first person vision.
Laser-arc hybrid welding for the cover plate of ITER TF coil (2007)

The toroidal field coil is manufactured as one of superconducting coil systems in the ITER. For welding the cover plate of TF coil, the prevention of the thermal effect on the coil and the deformation of the whole coil are required. Moreover, the application of high efficient welding is required in consideration for the productivity. Therefore, laser-arc hybrid welding process was investigated for the application to the cover plate welding, because its process is superior in the tolerance of the joint gap and the ease of the control for the heat input. In the experiment, it was confirmed that the application of laser-arc hybrid welding with the double gas shielding for high concentration arc and the filler wire for controlling the deposit amount is effective in the joint gap up to 0.8mm. Besides, twin spot laser head with the arc was developed in order to weld the both sides of cover plate simultaneously. By the optimization of welding condition for twin spot laser-arc hybrid welding process, it was confirmed to be effective in the prevention of the gap movement during welding and the acquisition of the proper penetration without the weld defect. Finally, the effectiveness of laser-arc hybrid welding for the welding deformation and the weldability on the quality was verified by the scale model test with the actual shape.
Outlier Detection for Text Data : An Extended Version (2017)

The problem of outlier detection is extremely challenging in many domains such as text, in which the attribute values are typically non-negative, and most values are zero. In such cases, it often becomes difficult to separate the outliers from the natural variations in the patterns in the underlying data. In this paper, we present a matrix factorization method, which is naturally able to distinguish the anomalies with the use of low rank approximations of the underlying data. Our iterative algorithm TONMF is based on block coordinate descent (BCD) framework. We define blocks over the term-document matrix such that the function becomes solvable. Given most recently updated values of other matrix blocks, we always update one block at a time to its optimal. Our approach has significant advantages over traditional methods for text outlier detection. Finally, we present experimental results illustrating the effectiveness of our method over competing methods.