gebhart/patrepeval huggingface dataset:
Data-driven batch scheduling (2009)

In this paper, we develop data-driven strategies for batch computing schedulers. Current CPU-centric batch schedulers ignore the data needs within workloads and execute them by linking them transparently and directly to their needed data. When scheduled on remote computational resources, this elegant solution of direct data access can incur an order of magnitude performance penalty for data-intensive workloads. Adding data-awareness to batch schedulers allows a careful coordination of data and CPU allocation thereby reducing the cost of remote execution. We offer here new techniques by which batch schedulers can become data-driven. Such systems can use our analytical predictive models to select one of the four data-driven scheduling policies that we have created. Through simulation, we demonstrate the accuracy of our predictive models and show how they can reduce time to completion for some workloads by as much as 80%.
Copolymerization of ethylene with bicyclo[2.2.1]hept-5-ene-2-methanol: A facile route to hydroxyl functional poly(ethylene)s (1998)

A direct and efficient route to the synthesis of hydroxyl functional polyethylene was identified by copolymerization of ethylene with bicyclo[2.2.1]hept-5-ene-2-methanol prereacted with trimethylaluminium using the catalyst system metallocene/MAO. Copolymerization studies were conducted using three metallocenes, namely, Cp2ZrCl2, Et(ind)2ZrCl2 and Me2SiCp2ZrCl2 the last one of which gave a copolymer containing as much as 6.2 mol-% of alcohol. The effect of the Al/Zr ratio as well as of temperature was studied. The copolymers were characterized by means of 1H NMR, differential scanning calorimetry, and intrinsic viscosity measurements.
Effect of the Dihedral Angle of Biaryl-Bridged Bisphosphite Ligands on Enantioselectivity and Regioselectivity of Asymmetric Hydroformylation (2007)

Eight new biaryl-bridged bisphosphite ligands have been synthesized and applied in rhodium-catalyzed asymmetric hydroformylation of styrene, allyl cyanide, and vinyl acetate. X-ray crystallographic studies of square planar LRh(acac) complexes of four of these bisphosphite ligands revealed that the dihedral angle of the bridging biaryl moiety depends on its identity and lies between 59.8° and 80.0°. A correlation between the dihedral angle in these Rh complexes and hydroformylation enantioselectivity and regioselectivity for both allyl cyanide and vinyl acetate is reported. Smaller dihedral angles were found to lead to increased regio- and enantioselectivity. Density functional theory calculations of a five-coordinate model complex (LRh(CO)2H) show that decreased dihedral angles lead to smaller P−Rh−P bite angles. Although large bite angles have previously been correlated with increased hydroformylation regioselectivity, these results provide the first demonstration of a bite angle effect on enantioselectivity in asymmetric hydroformylation.
Dynamic Double Directional Propagation Channel Measurements at 28 GHz - Invited Paper (2018)

This paper presents results from the (to our knowledge) first dynamic double-directionally resolved measurement campaign at mm-wave frequencies for an outdoor microcellular scenario. The measurements are performed with USC's real- time channel sounder equipped with phased array antennas that can steer beams electrically in microseconds, allowing directional measurements in dynamic environments. Exploiting the phase coherency of the setup, the multi-path components can be tracked over time to investigate the temporal dependencies of the channel characteristics. We present results for time-varying path-loss, delay spread, mean angles and angular spreads observed at the transmitter (TX) and receiver (RX) in the presence of moving vehicles and pedestrians. Additionally, we investigate excess losses observed due to blockage by vehicles and compare the cases when TX and RX are using fixed beams or when they are capable of adjusting beam directions dynamically.
Pharmacological characterization of somatostatin receptor subtype 3 as a potential strategy to treat non-functioning pituitary adenomas (2018)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
A Hybrid Energy System Workflow for Energy Portfolio Optimization (2021)

This manuscript develops a workflow, driven by data analytics algorithms, to support the optimization of the economic performance of an Integrated Energy System. The goal is to determine the optimum mix of capacities from a set of different energy producers (e.g., nuclear, gas, wind and solar). A stochastic-based optimizer is employed, based on Gaussian Process Modeling, which requires numerous samples for its training. Each sample represents a time series describing the demand, load, or other operational and economic profiles for various types of energy producers. These samples are synthetically generated using a reduced order modeling algorithm that reads a limited set of historical data, such as demand and load data from past years. Numerous data analysis methods are employed to construct the reduced order models, including, for example, the Auto Regressive Moving Average, Fourier series decomposition, and the peak detection algorithm. All these algorithms are designed to detrend the data and extract features that can be employed to generate synthetic time histories that preserve the statistical properties of the original limited historical data. The optimization cost function is based on an economic model that assesses the effective cost of energy based on two figures of merit: the specific cash flow stream for each energy producer and the total Net Present Value. An initial guess for the optimal capacities is obtained using the screening curve method. The results of the Gaussian Process model-based optimization are assessed using an exhaustive Monte Carlo search, with the results indicating reasonable optimization results. The workflow has been implemented inside the Idaho National Laboratory’s Risk Analysis and Virtual Environment (RAVEN) framework. The main contribution of this study addresses several challenges in the current optimization methods of the energy portfolios in IES: First, the feasibility of generating the synthetic time series of the periodic peak data; Second, the computational burden of the conventional stochastic optimization of the energy portfolio, associated with the need for repeated executions of system models; Third, the inadequacies of previous studies in terms of the comparisons of the impact of the economic parameters. The proposed workflow can provide a scientifically defendable strategy to support decision-making in the electricity market and to help energy distributors develop a better understanding of the performance of integrated energy systems.
Non-invasive estimate of the mechanical properties of peripheral arteries from ultrasonic and photoplethysmographic measurements (1991)

The non-linear elastic response of arteries implies that their mechanical properties depend strongly on blood pressure. Thus, dynamic measurements of both the diameter and pressure curves over the whole cardiac cycle are necessary to characterise properly the elastic behaviour of an artery. We propose a novel method of estimating these mechanical properties based on the analysis of the arterial diameter against pressure curves derived from ultrasonic and photoplethysmographic measurements. An ultrasonic echo tracking device has been developed that allows continuous recording of the internal diameter of peripheral arteries. It measures the diameter 300 times per second with a resolution of 2.5 microns. This system is linked to a commercially available light-plethysmograph which continuously records the finger arterial pressure (0.25 kPa accuracy). Because of the finite pulse wave velocity, the separation between the diameter and the pressure measurement sites causes a hysteresis to appear in the recorded diameter-pressure curve. Using a model based on haemodynamic considerations, the delay between the diameter variations and the finger arterial pressure is first eliminated. As the pulse wave velocity depends on the pressure, the delay is determined for each pressure value. The relationship between pressure and diameter is then described by a non-linear mathematical expression with three parameters, which best fits the recorded data. The dynamic local behaviour of the vessel is fully characterised by these parameters. Compliance, distensibility and pulse wave velocity can then be calculated at each pressure level. Thus, the mechanical behaviour of peripheral human arteries can now be characterised non-invasively over the pressure range of the whole cardiac cycle. The results obtained in vivo on human radial and brachial arteries show that a thorough analysis of the compliance-pressure curves and their modifications (curving, shift) is needed in order to compare two different vessels in a meaningful way.
Advances in Sickle Cell Disease Treatment: from Drug Discovery Until the Patient Monitoring (2011)

Sickle cell disease (SCD) is one of the most prevalent hematological diseases in the world. Despite the immense progress in molecular knowledge about SCD in last years few therapeutical sources are currently available. Nowadays the treatment is performed mainly with drugs such as hydroxyurea or other fetal hemoglobin inducers and chelating agents. This review summarizes current knowledge about the treatment and the advancements in drug design in order to discover more effective and safe drugs. Patient monitoring methods in SCD are also discussed.
Data Supplement from Comprehensive Biomarker Analysis and Final Efficacy Results of Sorafenib in the BATTLE Trial (2023)

&lt;p&gt;Supplementary Figure 1: Heatmap of the 68 non-small cell lung cancer cell lines with EGFR wild-type used to train the Sorafenib Sensitivity Signature; Supplementary Figure 2: Heatmap of the 37 patients with EGFR mutant tumors using the Sorafenib Sensitivity signature; yes: disease control at 8 weeks; no: no disease control at 8 weeks.&lt;/p&gt;
Stable Postfullerene Solar Cells via Direct C–H Arylation Polymerization. Morphology–Performance Relationships (2019)

The scope of the environmentally benign direct C–H arylation polymerization (DARP) process is validated and significantly extended in the synthesis of a high-performance benzodithiophene-based copolymer series, PBDT(Ar)-FTTE, with previously untested and systematically varied heteroaryl (Ar) substituents. Bulk-heterojunction (BHJ) polymer solar cells (PSCs) containing the high-performance nonfullerene acceptor (NFA) ITIC-Th and DARP-derived donors are fabricated and evaluated, yielding PCEs as high as 8%. The relationships between Ar-sensitive copolymer structure, BHJ morphology, and PSC performance are elucidated through in-depth characterization of structural order, phase separation, and charge transport using SCLC, AFM, GIWAXS, R-SoXS, and NEXAFS measurements, which conclusively demonstrate the important effects of Ar-tunable, dimensionally smaller, and well-blended copolymer domains for maximum PSC performance. Smaller BHJ copolymer domains having greater ITIC-Th miscibility definitively correlate with enhanced JSC, FF, and PCE metrics. Surprisingly regarding cell performance durability, while unencapsulated PBDTT-FTTE:ITIC-Th PSCs deliver the highest initial PCE, the unencapsulated PBDTTF-FTTE:ITIC-Th devices exhibit the optimum combination of high initial photovoltaic metrics and stability, retaining nearly 90% of the initial PCE after 51 days in ambient conditions and 83% of initial PCE after 180 min under simulated solar illumination. Importantly, for this PBDT(Ar)-FTTE:ITIC-Th series, PSC photovoltaic stability correlates with the presence of large pure BHJ domains, and moreover rivals or exceeds the stability of the analogous fullerene-based PSCs. Together, these results argue that solar cells prepared with the environmentally benign DARP process and NFAs are promising for both greener and more stable solar energy generation.
Novel 89Zr cell labeling approach for PET-based cell trafficking studies (2015)

We have developed a robust, general, and biostable (89)Zr-DBN-based cell labeling strategy with promise for wide applications of PET-based non-invasive in vivo cell trafficking.
Engineered Spider Silk Protein‐Based Composites for Drug Delivery (2013)

Silk protein-based materials are promising materials for the delivery of drugs and other active ingredients, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) in combination with either a polyester (polycaprolactone) or a polyurethane (pellethane), and their physical properties are described. The release profiles are affected by both the film composition and the presence of enzymes, and release can be observed over a period of several weeks. Such silk-based composites have potential as drug eluting biocompatible coatings or implantable devices.
Electrohydraulic Lithotripsy of Renal and Ureteral Calculi (1990)

Electrohydraulic lithotripsy was used to manage 45 upper tract calculi (23 renal and 22 ureteral stones) in 40 patients. Electrohydraulic lithotripsy successfully fragmented 91% of the calculi. All ureteral fragments cleared; in 2 patients with renal calculi solitary 4 mm. stone fragments remained. There were no intraoperative or long-term complications directly related to the use of electrohydraulic lithotripsy in the upper urinary tract. We conclude that intrarenal and intraureteral electrohydraulic lithotripsy is a safe, effective, inexpensive means to perform intracorporeal lithotripsy.
Druggability of Mortalin for Cancer and Neuro-Degenerative Disorders (2012)

Mortalin is a member of Hsp70 family of stress chaperones. It was first identified as a protein involved in the senescence of mouse cells. Genetic studies revealed that there are two mouse mortalin alleles coding for two proteins (mot-1 and mot-2) that differ in only two amino acids in the carboxy-terminus, but have contrasting activities. Whereas mot-1 accelerated senescence, mot-2 extended the lifespan of mouse cells in culture. In human cells, only one kind of mortalin protein has been identified so far and is shown to be functionally equivalent to mouse mot-2. Whereas mortalin is enriched in cancer cells and contributes to carcinogenesis, the old age brain disorders show its deficiency. As we demystify its deux de machina, accumulating evidence reveal that mortalin may be “druggable” bidirectionally to either treat cancer or neuro-degenerative disorders. Keywords: Mortalin, chaperone, cancer, aging, target, therapy, Hsp70, alleles, senescence, neuro-degenerative disorders.
Three Phase PWM AC/DC Converter with Leading Current Compensation Control (1995)

This paper propose a new current control technique for a three phase current fed type converter A minor loop compensation method is introduced to compensate leading current resulting from the presence of input filter and to minimize input current oscillation resulting from the resonance between input AC filter capacitor and source inductance of utility system This allows the use of considerably big filter capacitor to minimize input current and input voltage distortion. Even though the converter switching frequency is lowly limited with the new current controller, the sinusoidal input current at unity power factor is easily achieved. Analysis, design of the new controller are described and verified by experimental results.
Optical implementation of a quadratic associative memory by using the polarization-encoding process (1990)

As a higher-order associative memory of a neural network, the quadratic associative memory is implemented holographically by using the polarization-encoding process. The use of polarization encoding to represent sign in the quadratic associative memory tensor is made by twisted nematic liquid-crystal light modulators. Experimental results of retrieving the stored objects from an incomplete input are presented.
Possible role of the vascular renin-angiotensin system in hypertension and vascular hypertrophy. (1992)

To investigate the vascular renin-angiotensin system in two-kidney, one clip (2K1C) hypertension, we measured angiotensinogen messenger RNA (mRNA) in the aorta and aortic and plasma angiotensin II (Ang II) concentration in 2K1C rats during early (4 weeks) and chronic (16 weeks) phases. Four weeks after clipping, there was no significant change in aortic angiotensinogen mRNA in both groups. However, the levels of plasma and aortic Ang II in 2K1C rats were significantly elevated compared with levels in control rats (p less than 0.05). Sixteen weeks after clipping, aortic angiotensinogen mRNA in 2K1C rats did not differ compared with the level in control rats. The aortic Ang II level in 2K1C rats was significantly increased compared with that in control rats (p less than 0.05), whereas there was no significant difference in the plasma Ang II level between the groups during this chronic phase. During both phases, morphological studies in 2K1C rats showed arteriosclerotic changes, with a significant increase in the wall-to-lumen ratio (p less than 0.01). The present study is the first to demonstrate an increase in vascular Ang II levels and concomitant morphological arteriosclerotic changes during both the early and chronic phases in 2K1C rats. Together with the results of our previous study that demonstrated an elevation of vascular renin activity during the early phase and increased vascular angiotensin converting enzyme activity during the chronic phase, we conclude that the elevated vascular renin activity and vascular angiotensin converting enzyme activity during each phase may play a dominant role in the increase in vascular Ang II observed during both phases.
Data center server packaging technology (2006)

The purpose of this paper is to describe BladeCenter/spl trade/ packaging technology and compare with 1U and 2U rack systems to illustrate the improvements. The power and thermal design challenges are described. The paper covers in detail power and thermal design advantages, and overall cost performance compared to 1U servers. A blade server is a rack-optimized server architecture designed to include the benefits of standardized 1U rack systems while eliminating the complications associated with these systems. The term BladeCenter refers to a chassis that can hold a number of hot-swappable devices called blades server. A blade sever is an independent server containing one or more processors, memory, disk storage, and network controllers. The BladeCenter was created to simplify the deployment of servers in an enterprise infrastructure.
Interdependence of cdk2 Activation and Interleukin-2Rα Accumulation in T Cells (2001)

We have shown previously that serum promotes T cell proliferation by acting with T cell receptor (TCR) agonists to efficiently down-regulate p27(Kip1) and activate cdk2-containing complexes. In the studies described here, the effect of serum on the expression of the alpha subunit of the interleukin-2 receptor (IL-2Ralpha) was examined. We found that serum was required for maximal and sustained IL-2Ralpha protein expression and consequent IL-2 signaling in TCR-activated splenocytes. Serum had no effect on IL-2Ralpha mRNA levels and thus modulates IL-2Ralpha expression post-transcriptionally. Unlike wild-type splenocytes, splenocytes exhibiting serum-independent cdk2 activation due to loss of p27(Kip1) efficiently expressed IL-2Ralpha in serum-deficient medium. Conversely, serum did not promote IL-2Ralpha accumulation in conditions in which cdk2 activity was blocked. These findings demonstrate that cdk2 activation is necessary and sufficient for IL-2Ralpha accumulation in TCR-stimulated splenocytes. On the other hand, IL-2 signaling was required (at least in part) for cdk2 activation in these cells. Thus, cdk2 activation, IL-2Ralpha expression, and IL-2 signaling are interdependent events, and we suggest that this feed-forward regulatory loop plays a key role in T cell mitogenesis.
Sympathetic Nerve Activity (SNA) and blood pressure (BP) responses to elevations in intracranial pressure (ICP) - Cushing's Mechanism in conscious normotensive and spontaneously hypertensive (SH) rats (2015)

In 1901, Cushing described a 'simple and definite law' where experimentally increasing ICP produces matching increases in BP, in order to maintain cerebral perfusion. In the ensuing years, the char...
Calcium‐modulated contractile proteins associated with the eucaryotic centrosome (1986)

Affinity-purified antibodies that recognize the 20,000-dalton molecular weight (20 kd) striated flagellar root protein of Tetraselmis striata have been used to identify antigenic homologs in other eucaryotic organisms of diverse evolutionary origins. Among the green algae, Tetraselmis and Chlamydomonas, and their colorless relative, Polytomella, the 20-kd homologs appear associated with basal bodies. This occurs most prominently in the form of flagellar roots of both striated and microtubule subtended types. Among cultured mammalian cells (PtK2 and primary mouse macrophage cell lines), flagellar root protein homologs appear as basal feet, pericentriolar fibrils, and pericentriolar satellites. Mammalian sperm cells also show flagellar root protein homologs associated with their basal bodies. We envisage a functional role for these fibrous calcium-sensitive contractile proteins in altering the orientation of centrioles or basal bodies with their associated MTOCs by responding to topological calcium fluxes.
A full functional wireless access for vehicular environments (WAVE) prototype upon the IEEE 802.11p standard for vehicular communications and networks (2012)

In this demonstration, we will reveal a full functional wireless access for vehicular environments (WAVE) prototype, which achieves the complete functions defined by the IEEE 802.11p standard through integrating effective and novel base-band algorithms including fast time-synchronization, multiple-stage multiple Doppler detection, accurate channel estimate, and joint QAM demodulation and convolution decoding, all upon the Cyclone III field programmable gate array (FPGA) development kit from the Terasic Company. The WAVE prototype has been extensively tested under various road conditions showing satisfied performances. The WAVE prototype has an Ethernet interface to connect with a computer, upon which media control access (MAC) protocols and a vehicular network simulator operate. Meanwhile, the prototype can also connect with an Acer Iconia Tablet running on the Android system through a universal series bus (USB) to support various intelligent transportation system (ITS) applications based on vehicular communications and networks. This activity is funded by several NSF grants and the CISCO Research Grant.