gebhart/patrepeval huggingface dataset:
ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies (2015)

A DCE-MRI software suite was implemented and tested using simulations. Its applicability to both preclinical and clinical datasets is shown. ROCKETSHIP was designed to be easily accessible for the beginner, but flexible enough for changes or additions to be made by the advanced user as well. The availability of a flexible analysis tool will aid future studies using DCE-MRI. A public release of ROCKETSHIP is available at https://github.com/petmri/ROCKETSHIP .
Distributed Recursive Gaussian Processes for RSS Map Applied to Target Tracking (2017)

We propose a distributed recursive Gaussian process (drGP) regression framework for building received-signal-strength (RSS) map. The proposed framework adopts independent mobile devices in prescribed local areas to construct local RSS maps through recursive computation of the posterior distribution of the RSS on a fixed set of grids as training data gradually become available. The training input positions can be either precise or subject to errors of known distribution. All the local RSS maps are then fused to give a global map in the second step. The proposed framework is of significantly reduced computational complexity and scalable to big data generated from large-scale sensor networks. We further demonstrate its use in both static fingerprinting and mobile target tracking. The experimental results show that with our distributed framework satisfactory positioning accuracy can be achieved with much less complexity and storage than the standard framework.
Complementary techniques of clustering and composite pattern analysis to Saccharomyces cerevisiae gene expression. (2003)

We present the combined application of clustering and composite pattern analysis to Saccharomyces cerevisiae gene expression and sequence data. The aim is to devise a system for the efficient investigation of the upstream regions associated with regulating the coordinated transcriptional response of genes via the location of cis-acting elements. The clustering algorithm presented allows clusters to overlap in light of the fact that many genes are regulated by multiple factors and/or are associated with multiple functions in the organism. The sequence clusters are analysed for shared monad and dyad patterns. These motifs are commonly regarded as putative cis-acting regulatory elements. Computationally, dyad patterns may be difficult and expensive to discover and verify if the sequences are very large. This has highlighted the need to obtain maximally--with regards to the pattern in question--'enriched' sets of sequences to uncover these motifs. We present overlapping clusters as an ideal basis for the discovery of conserved motifs.
Tissue Multicolor STED Nanoscopy of Presynaptic Proteins in the Calyx of Held (2013)

The calyx of Held, a large glutamatergic terminal in the mammalian auditory brainstem has been extensively employed to study presynaptic structure and function in the central nervous system. Nevertheless, the nanoarchitecture of presynaptic proteins and subcellular components in the calyx terminal and its relation to functional properties of synaptic transmission is only poorly understood. Here, we use stimulated emission depletion (STED) nanoscopy of calyces in thin sections of aldehyde-fixed rat brain tissue to visualize immuno-labeled synaptic proteins including VGluT1, synaptophysin, Rab3A and synapsin with a lateral resolution of approximately 40 nm. Excitation multiplexing of suitable fluorescent dyes deciphered the spatial arrangement of the presynaptic phospho-protein synapsin relative to synaptic vesicles labeled with anti-VGluT1. Both predominantly occupied the same focal volume, yet may exist in exclusive domains containing either VGluT1 or synapsin immunoreactivity. While the latter have been observed with diffraction-limited fluorescence microscopy, STED microscopy for the first time revealed VGluT1-positive domains lacking synapsins. This observation supports the hypothesis that molecularly and structurally distinct synaptic vesicle pools operate in presynaptic nerve terminals.
Comparison Between Centralized and Decentralized Storage Energy Management for Direct Wave Energy Converter Farm (2016)

This paper compares the sizing of distributed energy storage systems (ESS) with two control types in order to smooth a direct wave energy converter farm production, namely a centralized one that deals with the point of common coupling (PCC) power with aggregated information and a decentralized one that deals with each unit with only local information. The main objective is to compare the two controls on the basis of their life cycle cost. The ESS is necessary for grid integration in the case considered here due to the flicker constraint. The co-optimization strategies for both the sizing and the management of an ESS are based on a rule-based energy management and a sequential approach to deal with the power quality constraint. This management strategy has been optimized for each size in order to reduce aging speed while respecting the flicker criterion. The final design is expected to minimize total system cost. The centralized control clearly allowed smaller capacity. However, it may lead to an increase in cables losses compared with the decentralized case, although it is expected to be negligible under the conditions considered in this paper. The confirmation of this hypothesis will be the objective of future work.
Universal Design and Assistive Technology in Communication and Information Technologies: Alternatives or Complements? (1998)

Universal design and assistive technology present advantages and disadvantages in accommodating the needs of people with disabilities. The best solution may be a combination of the two, using universal design wherever possible and commercially practical and using assistive technologies wherever it is necessary or provides sufficient additional advantage to the user. Three approaches are discussed for the individual who is unable to interact with their world: change the individual, provide them with tools they can use, or change the environment. Examples of each are illustrated using personal workstations and shared, public, and encountered systems. The final decision may rest on commercial practicality, and several new technologies are explored. Ultimately, we need to continue to move forward both on the universal design and the assistive technology fronts if we are to address the needs of people with disabilities and those who are aging.
Digital coherent optical access networks (2013)

Digital coherent transceivers are potentially a disruptive technology for the optical access network. The salient features of a digital coherent optical access network are discussed, in addition to the photonic technology and DSP required for realization.
The omega-3 hydroxy fatty acid 7( S )-HDHA is a high-affinity PPARα ligand that regulates brain neuronal morphology (2022)

The nuclear receptor peroxisome proliferator-activated receptor alpha (PPARα) is emerging as an important target in the brain for the treatment or prevention of cognitive disorders. The identification of high-affinity ligands for brain PPARα may reveal the mechanisms underlying the synaptic effects of this receptor and facilitate drug development. Here, using an affinity purification-untargeted mass spectrometry (AP-UMS) approach, we identified an endogenous, selective PPARα ligand, 7(<i>S</i>)-hydroxy-docosahexaenoic acid [7(<i>S</i>)-HDHA]. Results from mass spectrometric detection of 7(<i>S</i>)-HDHA in mouse and rat brain tissues, time-resolved FRET analyses, and thermal shift assays collectively revealed that 7(<i>S</i>)-HDHA potently activated PPARα with an affinity greater than that of other ligands identified to date. We also found that 7(<i>S</i>)-HDHA activation of PPARα in cultured mouse cortical neurons stimulated neuronal growth and arborization, as well as the expression of genes associated with synaptic plasticity. The findings suggest that this DHA derivative supports and enhances neuronal synaptic capacity in the brain.
DEVELOPMENT OF A W-BEAM GUARDRAIL SYSTEM FOR USE ON A 2:1 SLOPE (2000)

A W-beam guardrail system was developed and crash tested for use on a 2:1 foreslope. The guardrail design was constructed with 2.66-mm (12-gauge) thick W-beam rails totaling 53.34 m in length and incorporated a half-post spacing section of 17.15 m. The W-beam rail was supported by fifteen W152x13.4 by 1,829-mm long steel posts, spaced 1,905 mm on center, and nineteen W152x13.4 by 2,134-mm long steel posts, spaced 952.5 mm on center. Routed, 150x200x360 wood spacer blockouts were used to block the rail away from each post. The research study included bogie testing on steel posts placed in sloped fill and one full-scale vehicle crash test, using a 3/4-ton pickup truck. The test, impacting at a speed of 100.7 km/hr and an angle of 28.5 deg, was conducted and reported in accordance with the requirements specified in NCHRP Report No. 350, Recommended Procedures for the Safety Performance Evaluation of Highway Features. The safety performance of the W-beam barrier system was determined to be acceptable according to Test Level 3 of the NCHRP Report No. 350 criteria.
Planning by adaptation: experimental results (2002)

A robot system operating in an environment in which there is uncertainty and change needs to combine the ability to react with the ability to plan ahead. In a previous paper we proposed a solution to the problems of integrating planning and reaction: cast planning as adaptation of a reactive system, the planner-reactor approach. In this paper, we present our first experimental results from this approach. The results indicate that the planner-reactor approach is an attractive option for integrating planning and reaction in a robot system, allowing smooth, online updates to the behavior, of a reactive system with little time and behavior penalties accruing from the use of a planner.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Feed-Rate-Limited Aerosol-Assisted Chemical Vapor Deposition of CdxZn1-xS and ZnS:Mn with Composition Control (1998)

Doped group 12 metal sulfides are important materials in the phosphor display industry. Control over the host lattice phase, composition, and dopant concentration is crucial for controlling the luminescence characteristics of these materials. Ternary thin films of CdxZn1-xS and ZnS:Mn were deposited by aerosol-assisted chemical vapor deposition (AACVD) using liquid delivery of toluene solutions of new single-source Zn−S and Cd−S precursors M(SOCC(CH3)3)2TMEDA (M = Cd, Zn; TMEDA = N,N,N,N-tetramethylethylenediamine) and Mn2(CO)10 as a source of Mn. Control over film composition, wherein the precursor solution and film stoichiometries were identical, was achieved by using feed-rate-limited deposition conditions. Films with compositions Cd0.75Zn0.25S, Cd0.50Zn0.50S, and Cd0.25Zn0.75S were deposited at 225 °C from 10 mmol solutions with the same Cd:Zn precursor mole ratios, respectively. A series of control experiments in which the precursor feed rate was varied confirmed the presence of feed-rate-limited film growth. Films of ZnS:Mn with 1−8 at. % Mn dopant levels were also deposited from solutions with the same Zn:Mn precursor mole ratios, respectively, using feed-rate-limited deposition strategies.
Isotropic 3D cardiac cine MRI allows efficient sparse segmentation strategies based on 3D surface reconstruction (2017)

The postprocessing workflow of 3D isotropic cardiac imaging strategies can be optimized using sparse segmentation and 3D surface reconstruction. Magn Reson Med 79:2665-2675, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Chanock, Robert -- 1950-59 -- Correspondence, Individual -- text, 1953 - 1959? (1953)

<a href="http://digitalprojects.libraries.uc.edu/sabin/fairuse/">Sabin Collection Fair Use Policy</a>
Urban canvas: Unfreezing street-view imagery with semantically compressed LIDAR pointclouds (2011)

Detailed 3D scans of urban environments are increasingly being collected with the goal of bringing more location-aware content to mobile users. This work converts large collections of LIDAR scans and street-view panoramas into a representation that extracts semantically meaningful components of the scene. Compressing this data by an order of magnitude or more enables rich user interactions with mobile applications that have a very good knowledge of the scene around them. These representations are suitable for integrating into physics engines and transmission over mobile networks — key components of modern AR entertainment solutions.
Patient and Practitioner Influences on the Placebo Effect in Irritable Bowel Syndrome (2009)

Personality and gender influenced the placebo response, but only in the warm, empathic, augmented group. This suggests that, to the degree a placebo effect is evoked by the patient-practitioner relationship, personality characteristics of the patient will be associated with the placebo response. In addition, practitioners differed markedly in effectiveness, despite standardized interactions. We propose that the quality of the patient-practitioner interaction accounts for the significant difference between the groups in placebo response.
The enzymic potential of tissue kallikrein (rK1) in rat submandibular saliva depends on whether it was secreted via constitutive or regulated pathways. (1997)

The enzymic activity and immunoreactivity of rat tissue kallikrein (rK1) secreted at rest by granular duct cells of unstimulated submandibular glands has been compared with that secreted on autonomic nerve stimulation. Although a direct vesicular, constitutive secretory pathway operates for rK1 secretion from granular duct cells of unstimulated and parasympathetically stimulated glands the rK1 was not present in a pro-form and actually showed a greater enzymic activity per unit immunoreactive protein than the granule-derived rK1 in sympathetically evoked saliva. Constitutively secreted rK1 was found to be in a single chain molecular form by reducing SDS gel electrophoresis. In contrast rK1 secreted from the storage granule pool of granular duct cells on sympathetic nerve stimulation was present in much higher amounts and occurred in both one-chain and two-chain forms as revealed by SDS gel electrophoresis under reducing conditions. The lower enzymic potential of rK1 in sympathetically evoked saliva might be accounted for by its conversion to a two-chain form.
The Emergence of Alternative Developers for Extreme Ultraviolet Lithography (2010)

Recent work on extreme ultraviolet (EUV) resists has shown the application of alternative resist processes as a possible solution to achieve lithographic performance targets. In this study, the potential of tetrabutylammonium hydroxide (TBAH) as a possible alternative to the currently used tetramethylammonium hydroxide developer solution was investigated. A significant improvement in lithographic performance was achieved using the TBAH developer. However, this developer solution has a relatively high freezing temperature, particularly at high concentrations. We report that the addition of glycerin to the TBAH developer lowered the freezing temperature without adversely affecting lithographic performance.
Correlation between peripapillary macular fiber layer thickness and visual acuity in patients with open-angle glaucoma (2010)

The highest correlation between the BCVA and the RNFLT in the mT sector was most likely due to the location of the maculopapillary bundle in this region of the optic disc. Our findings indicate that when the RNFLT in the mT sector is reduced to 40 mum, glaucoma treatment should be reconsidered.
Selective etching of thermotropic liquid crystalline polyesters (1987)

Abstract DSC, IR, ESCA, macroscopic etching rate measurements, analysis of etchant solution, and electron microscopy conclusively show that n ‐alkylamines (ethylamine, n ‐propylamine, n ‐butylamine, and n ‐pentylamine) and NaOH selectively degrade (etch) the ethylene terephthalate (ET)‐rich phase in glassy liquid crystalline poly( p ‐hydroxybenzoic acid‐co‐ethylene terephthalate) [P(HBA–ET)] with molar compositions 0.60:0.40 and 0.80:0.20. ESCA demonstrates the excellent selectivity of the n ‐alkylamine etchants in the 0.60:0.40 copolymer. The 50 Å top layer of the etched samples contains 95 mol% HBA. Treatment with H 2 SO 4 and NH 3 gives ambiguous results, and these compounds are not suitable as etchants. It is demonstrated by electron microscopy on the 0.60:0.40 copolymer, in accordance with earlier reports by Joseph et al., 5–8 that the ET‐rich phase is discontinuous (1–2 μm spheres) and surrounded by an HBA‐rich matrix. SEM is a useful tool for characterization of this morphology. However, both phases have a substracture which is revealed only by TEM. The morphology of the 0.80:0.20 copolymer is fine‐textured, which means that SEM is a less suitable method for the characterization of etched samples.
Vacuum sand-casting system for electric and electronic parts (2002)

The viscosity of potting materials for electronic parts increases greatly when the inorganic filler is densely packed. A vaccum sand-casting system has been developed, in which filler containing resin is potted into parts that are prefilled with silica sand. Dense packing of inorganic filler in the potting materials can thus be achieved. Using this system, parts can be miniaturized as a result of improved thermal conductivity. More efficient production is made possible by the shortened process time and automation of this system.
Targeted high throughput sequencing in clinical cancer Settings: formaldehyde fixed-paraffin embedded (FFPE) tumor tissues, input amount and tumor heterogeneity (2011)

The application of high throughput sequencing technologies in cancer genomics opens up a new dimension for the identification of disease mechanisms. In particular the ability to use small amounts of FFPE samples available from surgical tumor resections and histopathological examinations facilitates the collection of precious tissue materials. However, care needs to be taken in regard to the locations of the biopsies, which can have an influence on the prediction of copy number variations. Bearing these technological challenges in mind will significantly improve many large-scale sequencing studies and will - in the long term - result in a more reliable prediction of individual cancer therapies.
Supplementary Table 1 from PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer (2023)

&lt;p&gt;Arginine methylated peptides identified by SILAC-proteomics&lt;/p&gt;
Abstract PR01: Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange. (2013)

Abstract Aberrant activation of the small GTPase Ras by oncogenic mutation or constitutively active receptor tyrosine kinases (RTKs) results in the deregulation of cellular signals governing growth and survival in cancer. The guanine nucleotide exchange factor Son of Sevenless (SOS) catalyzes the rate-limiting step in the activation of Ras by exchanging GDP for GTP. SOS is therefore a key control point for the propagation of RTK and Ras signaling. Here we report the discovery of small molecules that bind to a unique pocket on the Ras:SOS:Ras complex, increase SOScat-catalyzed nucleotide exchange, and perturb Ras signaling pathways in cells. X-ray crystallographic studies of Ras:SOS:Ras complexed with these small molecules reveal that they bind in a hydrophobic pocket in the CDC25 domain of SOS adjacent to the Switch II region of Ras. The structure-activity relationships exhibited by these compounds can be rationalized on the basis of the x-ray structures of multiple co-complexes. In addition, structure-based mutational analyses indicate that this newly identified pocket is essential for compound activity. As predicted, these molecules increase Ras-GTP levels in cells. However, they unexpectedly inhibit MAPK and PI3K signaling. Our studies suggest a novel way to target K-Ras and offer possible starting points for the discovery of compounds that could be used to treat Ras-driven tumors. Citation Information: Mol Cancer Ther 2013;12(11 Suppl):PR01. Citation Format: Michael Burns, Qi Sun, Richard Daniels, J. Phillip Kennedy, DeMarco Camper, Jason Phan, Edward Olejniczak, Taekyu Lee, Alex Waterson, Olivia Rossanese, Stephen Fesik. Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr PR01.
Ferroelectric thin films of PbTiO3system prepared by sputtering deposition and their application to pyroelectric sensors (1989)

Abstract Highly c-axis oriented PbTiO3,Pb1−x/4O3(PLT), and tetragonal PbZrxTi1−xO3(PZT) thin films were successfully grown with good epitaxy on (100)-cleaved MgO single crystal and [100]-oriented Pt thin films by rf-magnetron sputtering method. It was found that the thin films have large pyroelectric currents and high figures of merit for infrared (IR) sensors without a poling treatment. High sensitive pyroelectric infrared sensors (point and linear array type) were fabricated by using PLT thin films with x = 0.1 (PL10) which are the most suitable for pyroelectric material. The linear array sensors with reticulated PL10 have a remarkably high specific detectivity D* of 5 × 108 cm Hz1/2/W and a very low thermal cross talk of 3% at 100 Hz.
Antibacterial Activity of Mometasone Furoate (2008)

Mometasone demonstrates antimicrobial activity against streptococci.
Genome-wide detection and characterization of positive selection in human populations (2019)

With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the human genome. Here we report an analysis of over 3 million polymorphisms from the International HapMap Project Phase 2 (HapMap2). We used ‘long-range haplotype’ methods, which were developed to identify alleles segregating in a population that have undergone recent selection, and we also developed new methods that are based on cross-population comparisons to discover alleles that have swept to near-fixation within a population. The analysis reveals more than 300 strong candidate regions. Focusing on the strongest 22 regions, we develop a heuristic for scrutinizing these regions to identify candidate targets of selection. In a complementary analysis, we identify 26 non-synonymous, coding, single nucleotide polymorphisms showing regional evidence of positive selection. Examination of these candidates highlights three cases in which two genes in a common biological process have apparently undergone positive selection in the same population: LARGE and DMD, both related to infection by the Lassa virus3, in West Africa; SLC24A5 and SLC45A2, both involved in skin pigmentation in Europe; and EDAR and EDA2R, both involved in development of hair follicles, in Asia.