gebhart/patrepeval huggingface dataset:
A Totally Implantable Drug Infusion Defice: Laboratory and Clinical Experience Using a Model with Single Flow Rate and New Design for Modulated Insulin Infusion (1980)

The Infusaid implantable infusion pump with a single delivery rate has maintained chronic intravenous heparin infusion in man for greater than 35 mo and for greater than 5 yr in the dog. Intra-arterial infuson of fluorodeoxyuridine has been maintained for greater than 8 mo in man. In a pilot study using a commercially available, transcutaneously controllable, magnetically activated valve for baseline superimposed bolus insulin infusion, the feasibility of maintaining near normal serum glucose in diabetic dogs was demonstrated. The effect of long-term intravenous cannulation was investigated; it was found that the intimal tissues of the vena cava surrounding the cannulae were largely unaltered and microemboli could not be detected in the lungs of the animals studied. Cannula plugging, which occurred on several occasions due to thrombus formation in the final centimeter of the cannula, has been solved by changes in pump design and refilling procedures. The problem of insulin precipitation in flow passages of the pump remains unsolved, but there are indications that substances entering the cannula from the blood may be involved. A new pump design for modulated insulin infusion is described.
Supplementary Figure 2 from Determinants of Successful CD8<sup>+</sup> T-Cell Adoptive Immunotherapy for Large Established Tumors in Mice (2023)

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MANAGEMENT OF ROAD HAULAGE COMPANIES TROLLEYBUS (1979)

This report deals with conditions, company structures and differences with respect to adoption and learning processes in road haulage companies. The report consists of empirical data collection and theoretical analysis in two parallel phases. The empirical part describes the situation and development of the road haulage industry together with 11 case studies of road haulage companies based on interviews. The conceptual and analyzing part of the report presents a learning process frame of reference and a discussion of the cases in terms of learning processes. The road haulage industry is described in terms of market organization, products and history. The case material consists of two one-lorry hauliers, three midsized hauliers and five one-lorry hauliers who are members of a hauliers co-operative. In a comparative analysis of the cases, the adoption processes of the companies are explained with the concepts of learning processes. Three vital concepts, used in the description of the adoption- and learning processes of the haulage companies, are related to each other in an analysis aimed at explaining the conditions for the function of the learning process. The three concepts and their relations are: (1) structure of haulage company, (2) learning process and (3) strategy of company. The analysis indicates that the learning process is weakened by strategies and structures that conceal market information, techniques and methods for information gathering, analysis, planning from the eyes of the organization. The possibilities of exchanging experiences have a positive influence on the learning process. (TRRL)
Trace-Gas Raman Spectroscopy Using Functionalized Waveguides (2016)

The vapor-phase Raman spectra of trace concentrations of chemicals are measured using highly evanescent silicon nitride rib waveguides functionalized with a top cladding that is designed to strongly sorb organophosphonates and other toxic species.
Grand-Canonical Model of Electrochemical Double Layers from a Hybrid Density–Potential Functional (2021)

A hybrid density-potential functional of an electrochemical interface that encompasses major effects in the contacting metal and electrolyte phases is formulated. Variational analysis of this functional yields a grand-canonical model of the electrochemical double layer (EDL). Specifically, metal electrons are described using the Thomas-Fermi-Dirac-Wigner theory of an inhomogeneous electron gas. The electrolyte solution is treated classically at the mean-field level, taking into account electrostatic interactions, ion size effects, and nonlinear solvent polarization. The model uses parametrizable force relations to describe the short-range forces between metal cationic cores, metal electrons, and electrolyte ions and solvent molecules. Therefore, the gap between the metal skeleton and the electrolyte solution, key to properties of the EDL, varies consistently as a function of the electrode potential. Partial charge transfer in the presence of ion specific adsorption is described using an Anderson-Newns type theory. This model is parametrized with density functional theory calculations, compared with experimental data, and then employed to unravel several interfacial properties of fundamental significance in electrochemistry. In particular, a closer approach of the solution phase toward the metal surface, for example, caused by a stronger ion specific adsorption, decreases the potential of zero charge and elevates the double-layer capacitance curve. In addition, the ion specific adsorption can lead to surface depolarization of ions. The present model represents a viable framework to model (reactive) EDLs under the constant potential condition, which can be used to understand multifaceted EDL effects in electrocatalysis.
Cardiac remodeling following reperfused acute myocardial infarction is linked to the concomitant evolution of vascular function as assessed by cardiovascular magnetic resonance (2016)

NCT01109225 on ClinicalTrials.gov site (April, 2010).
A multilevel fast direct solver for EM scattering from quasi-planar objects (2009)

A fast multilevel direct solver for electromagnetic scattering from quasi-planar objects is presented. The solver relies on the compression of the off-diagonal blocks in the impedance matrix, which describe interactions between distinct domains. The compression is performed in a number of steps. First, the scatterer is decomposed into sub-domains using a multilevel quad-tree hierarchical subdivision. Then, the field radiated by each sub-domain, onto the rest of the scatterer, is determined using a Non-uniform sampling grid approach. Subsequently, a rank-revealing QR decomposition is applied to the grid matrix to find the current basis functions that actually contribute to the radiated field. At the same time, the employed decomposition singles out the most important grid points (called grid skeleton), from which the field on the observation domain can be reconstructed. Finally, compression of the local interacting currents and fields inside each sub-domain is performed using the Schur's complement method. The non-interacting currents are solved locally, whereas interacting currents and grid skeletons are repeatedly aggregated with neighboring sections in a multilevel process. The resulting compressed system of equations is solved directly. The algorithm is analyzed for performance and stability. It is shown that approximately O(N <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1.5</sup> ) complexity is attained for the matrix compression and approximately O(N) for each right-hand-side solution, N being the number of unknowns. The analytical complexity estimates are supported by the results of a numerical case study.
Reduction of interfacial SiO2 at HfO2/Si interface with Ta2O5 cap (2013)

We investigated SiO2 interfacial layer (IL-SiO2) reduction with a Ta2O5 cap to realize the direct contact formation of HfO2 on a Si substrate for the equivalent oxide thickness scaling of Hf-based high-k gate dielectrics. X-ray reflectivity and x-ray photoelectron spectroscopy measurements revealed that the Ta2O5 cap was effective in taking oxygen from the IL-SiO2 and caused SiO2 reduction, which resulted from Ta diffusion into the HfO2 layer from the Ta2O5. With this technique, the Ta2O5 cap deposited on the HfO2/SiO2/Si reduced the IL-SiO2 by 0.2 nm without any thermal treatment. Rapid thermal annealing at 300 °C enhanced the IL-SiO2 reduction. This result reveals that our method is a promising approach to achieve direct contact between the high-k layer and the Si substrate. Therefore, Ta2O5 has good potential as a cap for SiO2 interfacial layer reduction.
Identification of a novel domain shared by putative components of the endocytic and cytoskeletal machinery (1999)

We have identified a approximately 140 amino acid domain that is shared by a variety of proteins in budding and fission yeast, nematode, rat, mouse, frog, oat, and man. Typically, this domain is located within 20 residues of the N-terminus of the various proteins. The percent identity among the domains in the 12 proteins ranges from 42 to 93%, with 16 absolutely conserved residues: N-x(11-13)-V-x2-A-T-x(34-36)-R-x(7-8)-W-R-x3-K-x12-G-x-E-x15 -L-x11-12-D-x-G-R-x11-D-x7-R. Even though these proteins share little beyond their segment of homology, data are emerging that several of the proteins are involved in endocytosis and or regulation of cytoskeletal organization. We have named this protein segment the ENTH domain, for Epsin N-terminal Homology domain, and hypothesize that it is a candidate for binding specific ligands and/or enzymatic activity in the cell.
Synthesis and properties of new polyamides derived from 2,2‐bis[4‐[2‐(4‐aminophenoxy)ethoxy]phenyl]sulfone by direct polycondensation (1999)

A series of new polyamides containing both sulfone and oxyethylene moieties in the polymer chain was prepared by the direct polycondensation of the diamine monomer 2,2-bis[4-[2-(4-aminophenoxy)ethoxy]phenyl]sulfone (BAEPS) and various aromatic dicarboxylic acids in N-methyl-2-pyrrolidinone (NMP) using triphenyl phosphite and pyridine as condensing agents. Polymers were produced with inherent viscosities of 0.30–0.60 dl/g and identified by elemental analysis, and infrared and nuclear magnetic resonance spectra. Most of the polymers were readily dissolved in polar solvents such as NMP, dimethylsulfoxide, N,N-dimethylacetamide, N,N-dimethylformamide and m-cresol at room temperature. Polymers containing rigid and symmetric p-phenylene, naphthalene and p-biphenylene moieties revealed a crystalline nature and showed no solubility in organic solvents. These polyamides had 10% weight loss temperatures ranging between 423 and 465 °C in nitrogen atmosphere and glass transition temperatures between 170 and 305 °C. The polymers with crystallinity nature exhibited melting endotherms (Tm) below 386 °C in differential scanning calorimetry trace. Copyright © 1999 John Wiley & Sons, Ltd.
Nucleotide Sequence Analysis of the Enteropathogenic Escherichia coli Adherence Factor Plasmid pMAR7 (2006)

The complete nucleotide sequence was determined for pMAR7, an enteropathogenic Escherichia coli (EPEC) adherence factor (EAF) plasmid that contains genes encoding a type IV attachment pilus (Bfp) and the global virulence regulator per. Prototypic EAF plasmid pMAR7 is self-transmissible, unlike the smaller EAF plasmid pB171, which has no genes encoding conjugative functions. The tra locus, a highly conserved 33-kb segment found in pMAR7, is similar to the tra (conjugation) region of the F plasmid. ISEc13 copies flanking the pMAR7 tra region could potentially mobilize or delete the tra genes. Hybridization of 134 EPEC strains showed that a complete tra region is present only in strains of the EPEC1 clonal group. This study confirms EPEC's potential for dissemination of virulence attributes by horizontal transfer of the EAF plasmid.
Development of an ELISA-based kit for the on-farm determination of progesterone in milk (2007)

Effective reproductive management is a crucial concern in the dairy industry and missed oestrus and late recognition of unsuccessful insemination can lead to substantial financial loss. Progesterone levels change in a predictable manner with progress of the oestrus cycle and with the onset of pregnancy. We report here the development of a simple ELISA test for the measurement of progesterone levels in bovine milk. The method is based on the use of polyclonal antibodies raised against 11α-hydroxyprogesterone-hemisuccinate and competition for antibody binding sites between free progesterone and horseradish peroxidase-labelled progesterone. Binding is quantified by means of the colour reaction between horseradish peroxidase and 3,3',5,5'-tetramethylbenzidine. The method has proved to be a cost effective, sensitive and easy to perform alternative to currently available methods of oestrus and pregnancy detection. The practical feasibility of the method has been proven under dairy farm conditions.
Observation of Electron Energies Beyond the Linear Dephasing Limit from a Laser-Excited Relativistic Plasma Wave (1998)

The spatial extent of the plasma wave and the spectrum of the accelerated electrons are simultaneously measured when the relativistic plasma wave associated with Raman forward scattering of an intense laser beam reaches the wave breaking limit. The maximum observed energy of 94 MeV is greater than that expected from the phase slippage between the electrons and the accelerating electric field as given by the linear theory for preinjected electrons. The results are in good agreement with 2D particle-in-cell code simulations of the experiment.
Are fewer cases of diabetes mellitus diagnosed in the months after SARS-CoV-2 infection? (2022)

Long-term sequelae of severe acute respiratory coronavirus-2 (SARS-CoV-2) infection may include an increased incidence of diabetes. Our objective was to describe the temporal relationship between new diagnoses of diabetes mellitus and SARS-CoV-2 infection in a nationally representative database. There appears to be a sharp increase in diabetes diagnoses in the 30 days surrounding SARS-CoV-2 infection, followed by a decrease in new diagnoses in the post-acute period, up to 360 days after infection. These results underscore the need for further investigation, as understanding the timing of new diabetes onset after COVID-19 has implications regarding potential etiology and screening and treatment strategies.
Critical Reflection Illumination Analysis (2012)

We propose a critical reflection illumination analysis to evaluate subsalt illumination in areas where high velocity contrasts create shadow zones. This phenomenon often occurs at the base and edges of salt bodies, for example. When critical reflection occurs, continued iterations of processing and imaging, or increasing the offset/azimuth of the surface acquisition will result in limited if any improvement in the imaging of subsalt targets. The proposed illumination analysis can help avoid these expensive processing/imaging and acquisition efforts for areas that are in the critical/post-critical reflection regime. This analysis is a general method that can also be used in other high velocity contrast scenarios.
CEST imaging at 9.4 T using adjusted adiabatic spin‐lock pulses for on‐ and off‐resonant T1⍴‐dominated Z‐spectrum acquisition (2018)

By adapting a pulse shape for low-power SL experiments, we were able to acquire robust on- and off-resonant adiabatic SL prepared images in vivo at 9.4 T. This development leads directly to SL Z-spectrum acquisition, beneficial for chemical-exchange-weighted MRI.
Radiofrequency Coils for Musculoskeletal Magnetic Resonance Imaging (2010)

Dedicated and specialized radiofrequency coils are critical for high quality musculoskeletal magnetic resonance imaging (MRI). Dedicated coils improve the signal to noise ratio, allowing for faster or higher resolution examinations. Transmit-receive coils can reduce heating at high field strength. Finally, novel radiofrequency coils can be used for assessment of tissue biochemistry, as seen with sodium MRI.
Defining a second epitope for heparin-induced thrombocytopenia/thrombosis antibodies using KKO, a murine HIT-like monoclonal antibody (2002)

Heparin-induced thrombocytopenia/thrombosis (HIT/T) is a common complication of heparin therapy that is caused by antibodies to platelet factor 4 (PF4) complexed with heparin. The immune response is polyclonal and polyspecific, ie, more than one neoepitope on PF4 is recognized by HIT/T antibodies. One such epitope has been previously identified; it involves the domain between the third and fourth cysteine residues in PF4 (site 1). However, the binding sites for other HIT/T antibodies remain to be defined. To explore this issue, the binding site of KKO, an HIT/T-like murine monoclonal antibody, was defined. KKO shares a binding site with many HIT/T antibodies on PF4/heparin, but does not bind to site 1 or recognize mouse PF4/heparin. Therefore, the binding of KKO to a series of mouse/human PF4 chimeras complexed with heparin was examined. KKO recognizes a site that requires both the N terminus of PF4 and Pro34, which immediately precedes the third cysteine. Both regions lie on the surface of the PF4 tetramer in sufficient proximity (within 0.74 nm) to form a contiguous antigenic determinant. The 10 of 14 HIT/T sera that require the N terminus of PF4 for antigen recognition also require Pro34 to bind. This epitope, termed site 2, lies adjacent to site 1 in the crystal structure of the PF4 tetramer. Yet sites 1 and 2 can be recognized by distinct populations of antibodies. These studies further help to define a portion of the PF4 tetramer to which self-reactive antibodies develop in patients exposed to heparin.
Heterologous Expression of Phanerochaete Chrysosporium Cellobiose Dehydrogenase in Trichoderma Reesei (2020)

Abstract Background: Cellobiose dehydrogenase from Phanerochaete chrysosporium ( Pc CDH) is a key enzyme in lignocellulose depolymerization, biosensors and biofuel cells. For these applications, it should retain important molecular and catalytic properties when recombinantly expressed. While homologous expression is time-consuming and the prokaryote Escherichia coli is not suitable for expression of the two-domain flavocytochrome, the yeast Pichia pastoris is hyperglycosylating the enzyme. Fungal expression hosts like Aspergillus niger and Trichoderma reesei were successfully used to express CDH from the ascomycete Corynascus thermophilus . This study describes the expression of basidiomycetous Pc CDH in T. reesei ( Pc CDH Tr ) and the detailed comparison of its molecular, catalytic and electrochemical properties in comparison with Pc CDH expressed by P. chrysosporium and P. pastoris ( Pc CDH Pp ). Results: Pc CDH Tr was recombinantly produced with a yield of 600 U L -1 after 4 days, which is fast compared to the secretion of the enzyme by P. chrysosporium . Pc CDH Tr and PcCDH were purified to homogeneity by two chromatographic steps. Both enzymes were comparatively characterized in terms of molecular and catalytic properties. The pH optima for electron acceptors are identical for Pc CDH Tr and Pc CDH. The determined FAD cofactor occupancy of 70% for Pc CDH Tr is higher than for other recombinantly produced CDHs and its catalytic constants are in good accordance with those of Pc CDH. Mass spectrometry showed high mannose-type N -glycans on Pc CDH, but only single N -acetyl-d-glucosamine additions at the six potential N-glycosylation sites of Pc CDH Tr , which indicates the presence of an endo-N-acetyl-b-d-glucosaminidase in the supernatant. Conclusions: Heterologous production of Pc CDH Tr is faster and the yield higher than secretion by P. chrysosporium . It also does not need a cellulose-based medium that impedes efficient production and purification of CDH by binding to the polysaccharide. The obtained high uniformity of Pc CDH Tr glycoforms will be very useful to investigate electron transfer characteristics in biosensors and biofuel cells, which are depending on the spatial restrictions inflicted by high-mannose N-glycan trees. The determined catalytic and electrochemical properties of Pc CDH Tr are very similar to those of Pc CDH and the FAD cofactor occupancy is good, which advocates T. reesei as expression host for engineered Pc CDH for biosensors and biofuel cells.
Developmentally Regulated Transgene Silencing in Torenia. (1998)

We demonstrated developmental transgene silencing and resetting in torenia (Torenia fournieri Lind.). The experiments used transformants carrying the neonrycin phosphotransferase II gene, the β-glucuronidase (GUS) gene, and tbe hygrounycin phosphotransferase gene. GUS activity was measured at various developmental stages in GUS-homozygous and GUS-hemizygous plants derived from a primary transformant, R0-1. Rapid silencing of the GUS gene occurred 12 to 19 days after germination in the homozygous plants, while it occurred at a later developmental stage, 54 days after germination, in the hemizygous plants. The silenced state seemed to be stable through vegetative propagation in both the homozygotes and the hemizygotes. Northern blot analysis showed that mRNA reduction correlated with a reduction in GUS activity. A single GUS gene locus was sufficient to trigger the silencing, and initial levels of GUS activity correlated with the timing of silencing. These results suggested that the GUS gene silencing observed in torenia is not dependent on allelic interaction of the GUS genes, but is correlated with a dose effect. This type of silencing can be explained by the RNA threshold model.
Skin toxicity as a risk factor for major infections in breast cancer patients treated with docetaxel (2004)

Docetaxel-related skin toxicity, oral and gastrointestinal mucosal toxicity, and changes in blood cell counts were investigated as predictive factors for major infections in 143 women treated with 3-weekly docetaxel (100 mg/m2) as second-line therapy for metastatic breast cancer in a randomized trial. Each patient with a major infection (n = 37) was compared with two controls. Skin toxicity (odds ratio 2.97, 95% CI 1.37-6.47), oral mucositis (1.98, CI 1.30-3.04), and the leukocyte nadir (0.12, CI 0.02-0.51) were significantly associated with a major infection in a univariate logistic regression analysis. In a multivariate analysis, skin toxicity was the only independent factor predictive for grade 3 to 4 infection (2.75, CI 1.00-7.58). A major infection was diagnosed in 62% (8 out of 13) of the docetaxel cycles in severely (grade 4) leukopenic patients who had grade 2 to 4 skin toxicity. Major infections are common in leukopenic patients who develop docetaxel-associated skin toxicity, and leukopenic patients presenting with docetaxel-induced skin toxicity may be candidates for prophylactic anti-infection measures such as prophylactic therapy with hematopoietic growth factors.
A novel strategy for preparing mechanically robust ionically cross-linked alginate hydrogels (2011)

The properties of alginate films modified using two cross-linker ions (Ca(2+) and Ba(2+)), comparing two separate cross-linking techniques (the traditional immersion (IM) method and a new strategy in a pressure-assisted diffusion (PD) method), are evaluated. This was achieved through measuring metal ion content, water uptake and film stability in an ionic solution ([Ca(2+)] = 2 mM). Characterization of the internal structure and mechanical properties of hydrated films were established by cryogenic scanning electron microscopy and tensile testing, respectively. It was found that gels formed by the PD technique possessed greater stability and did not exhibit any delamination after 21 day immersion as compared to gels formed by the IM technique. The Ba(2+) cross-linked gels possessed significantly higher cross-linking density as reflected in lower water content, a more dense internal structure and higher Young's modulus compared to Ca(2+) cross-linked gels. For the Ca(2+) cross-linked gels, a large improvement in the mechanical properties was observed in gels produced by the PD technique and this was attributed to thicker pore walls observed within the hydrogel structure. In contrast, for the Ba(2+) cross-linked gels, the PD technique resulted in gels that had lower tensile strength and strain energy density and this was attributed to phase separation and larger macropores in this gel.