gebhart/patrepeval huggingface dataset:
Real-Time Massive MIMO Channel Prediction: A Combination of Deep Learning and NeuralProphet (2022)

Channel state information (CSI) is of pivotal importance as it enables wireless systems to adapt transmission parameters more accurately, thus improving the system's overall performance. However, it becomes challenging to acquire accurate CSI in a highly dynamic environment, mainly due to multi-path fading. Inaccurate CSI can deteriorate the performance, particularly of a massive multiple-input multiple-output system. This paper adapts machine learning for CSI prediction. Specifically, we exploit time-series models of deep learning (DL) such as recurrent neural network (RNN) and bidirectional long-short term memory. Further, we use NeuralProphet (NP), a recently introduced time-series model, composed of statistical components, e.g., autoregressive and Fourier terms, for CSI prediction. Inspired by statistical models, we also develop a novel hybrid framework comprising RNN and NP to achieve better prediction accuracy. The proposed channel predictors performance is evaluated on a real-time dataset recorded at the Nokia Bell-Labs campus in Stuttgart, Germany. Numerical results show that DL brings performance gain when used with statistical models and showcases robustness.
Abstract 5447: Breast cancer chemoprevention by ‘Jamun’, the Indian blackberry: Potential mechanisms (2012)

Abstract Dark-colored berries are gaining increasing attention lately for their chemopreventive and chemotherapeutic activities. Jamun (Syzygium cumini L.), the Indian blackberry is perhaps the only berry that has the diversity of anthocyanins of blueberry and abundance of ellagic acid present in black raspberry. We previously reported chemoprotective activities in jamun pulp extract and powder in vitro and short-term in vivo studies (Aqil et al. AACR 2010, Vol. 51, Abst. # 5688). Here we report anti-cancer potential of jamun pulp powder against estrogen mediated breast cancer and the role of miRNAs and other targets in the disease inhibition. Groups of female ACI rats were given AIN-93M diet or diet supplemented with jamun pulp powder (5%, w/w). Two weeks later, animals from each group were treated with subcutaneous silastic implants of 17β-estradiol (1.2 cm; 9 mg). Additional groups of animals received control or experimental diet in the absence of estrogen. Diet and water were provided ad libitum. Twelve weeks later animals were palpated weekly for the mammary tumors, and all groups were euthanized when tumors incidence reached over 90% in control group. Compared to control, jamun-supplemented diet delayed the first tumor appearance by 21 days, and significantly reduced the tumor incidence (65% vs 96%), tumor burden (313±95 vs 661±123 mm3) and tumor multiplicity (1.8±0.3 vs 4.2±0.4 tumors/rat). The experimental diet also significantly reduced the estrogen-associated growth of pituitary prolactinomas, circulating prolactin and estradiol levels and the mammary cell proliferation (PCNA) markers. Mechanistically, the jamun diet significantly offset estrogen-associated increases in mammary cell proliferation, ER-α and cyclin D1 as determined by western blot analysis. We have recently identified ‘miRNA signature’ associated with estrogen treatment (Munagala et al. AACR 2011, Vol. 52, Abst. # 155). All miRNAs that were either significantly overexpressed (miR-182 and miR-375) or underexpressed (miR-127 and miR-206) as a result of estrogen treatment were significantly protected by intervention with the jamun diet. Targets for these miRNAs remain to be identified. Together, our data show that jamun significantly offset estrogen-mediated alterations in i) mammary cell proliferation; ii) ER-α; iii) cyclin D1, and iv) candidate miRNAs, and that the modulation of these biomarkers correlated with the reduction in mammary carcinogenicity. (Supported by CA-125152, CA-118114 and Agnes Brown Duggan Endowment). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5447. doi:1538-7445.AM2012-5447
Sorption and diffusion of a tribasic acid dye in nylon 6 membrane in the presence of NaCl (1985)

Abstract Measurements of sorption and diffusion of a tribasic acid dye in nylon 6 membranes in the presence of NaCl are reported and critically analyzed by the dual‐mode sorption and diffusion models consisting of either simple partition plus ion exchange, or simple partition plus “Langmuir” modes. It is shown that the former treatment, which is the physically more realistic one, also provides a generally better fit to the data.
Knowledge representation and reasoning in a software synthesis architecture (1992)

The knowledge representation and reasoning strategies in an automatic program synthesis architecture called ELF are described. ELF synthesizes computer-aided design (CAD) tools that automatically route wires in VLSI circuits. The design space ELF confronts, requires it to understand various physical technologies, to select an appropriate procedure-level decomposition, to choose algorithms and data structures, to manage any interdependencies, and to generate efficient code. ELF manages the design space using a variety of knowledge sources, including domain-specific knowledge. The manner in which knowledge is used determines the representation method of choice. The effectiveness of these ideas is illustrated via a tour through the synthesis steps for a specific routing tool, and a brief discussion of the performance of the resulting synthetic router as measured against an industrial tool.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Radiation therapy dose and androgen deprivation therapy in localized prostate cancer: a meta-regression of 5-year outcomes in phase III randomized controlled trials (2021)

While limited by between-study heterogeneity and a lack of individual patient data, this meta-analysis suggests that adding ADT, versus increasing RT dose alone, offers a more consistent improvement in clinical endpoints.
Protective Allele for Multiple Sclerosis HLA-DRB1*01:01 Provides Kinetic Discrimination of Myelin and Exogenous Antigenic Peptides (2020)

Risk of the development of multiple sclerosis (MS) is known to be increased in individuals bearing distinct class II human leukocyte antigen (HLA) variants, whereas some of them may have a protective effect. Here we analyzed distribution of a highly polymorphous HLA-<i>DRB1</i> locus in more than one thousand relapsing-remitting MS patients and healthy individuals of Russian ethnicity. Carriage of HLA<i>-DRB1</i>*15 and HLA<i>-DRB1</i>*03 alleles was associated with MS risk, whereas carriage of HLA<i>-DRB1</i>*01 and HLA<i>-DRB1</i>*11 was found to be protective. Analysis of genotypes revealed the compensatory effect of risk and resistance alleles <i>in trans</i>. We have identified previously unknown MBP<sub>153-161</sub> peptide located at the C-terminus of MBP protein and MBP<sub>90-98</sub> peptide that bound to recombinant HLA-DRB1*01:01 protein with affinity comparable to that of classical antigenic peptide 306-318 from the hemagglutinin (HA) of the influenza virus demonstrating the ability of HLA-DRB1*01:01 to present newly identified MBP<sub>153-161</sub> and MBP<sub>90-98</sub> peptides. Measurements of kinetic parameters of MBP and HA peptides binding to HLA-DRB1*01:01 catalyzed by HLA-DM revealed a significantly lower rate of CLIP exchange for MBP<sub>153-161</sub> and MBP<sub>90-98</sub> peptides as opposed to HA peptide. Analysis of the binding of chimeric MBP-HA peptides demonstrated that the observed difference between MBP<sub>153-161</sub>, MBP<sub>90-98</sub>, and HA peptide epitopes is caused by the lack of anchor residues in the C-terminal part of the MBP peptides resulting in a moderate occupation of P6/7 and P9 pockets of HLA-DRB1*01:01 by MBP<sub>153-161</sub> and MBP<sub>90-98</sub> peptides in contrast to HA<sub>308-316</sub> peptide. This leads to the P1 and P4 docking failure and rapid peptide dissociation and release of empty HLA-DM-HLA-DR complex. We would like to propose that protective properties of the HLA<i>-DRB1</i>*01 allele could be directly linked to the ability of HLA-DRB1*01:01 to kinetically discriminate between antigenic exogenous peptides and endogenous MBP derived peptides.
Separation of amino acid enantiomers by micelle-enhanced ultrafiltration (2000)

A Micelle-enhanced ultrafiltration (MEUF) separation process was investigated that can potentially be used for large-scale enantioseparations. Copper(II)-amino acid derivatives dissolved in nonionic surfactant micelles were used as chiral selectors for the separation of dilute racemic amino acids solutions. For the alpha-amino acids phenylalanine, phenylglycine, O-methyltyrosine, isoleucine, and leucine good separation was obtained using cholesteryl L-glutamate and Cu(II) ions as chiral selector with an operational enantioselectivity (alpha(op)) up to 14.5 for phenylglycine. From a wide set of substrates, including four beta-amino acids, it was concluded that the performance of this system is determined by two factors: the hydrophobicity of the racemic amino acid, which results in a partitioning of the racemic amino acid over micelle and aqueous solution, and the stability of the diastereomeric complex formed upon binding of the amino acid with the chiral selector. The chiral hydrophobic cholesteryl anchor of the chiral selector also plays an active role in the recognition process, since inversion of the chirality of the glutamate does not yield the reciprocal enantioselectivities. However, if the cholesteryl group is replaced by a nonchiral alkyl chain, reciprocal operational enantioselectivities are found with enantiomeric glutamate selectors.
Phase Formation and Dielectric Characterization of the Bi 2 O 3 –TeO 2 System Prepared in an Oxygen Atmosphere (2004)

Solid‐state synthesis of compositions from the Bi 2 O 3 –TeO 2 system show that, under an oxygen atmosphere, Te 4+ oxidizes to Te 6+ and yields four room‐temperature stable compounds: Bi 2 Te 2 O 8 , Bi 2 TeO 6 , Bi 6 Te 2 O 15 , and new a compound with the nominal composition 7Bi 2 O 3 ·2TeO 2 . Dense ceramics can be prepared from all these compounds by sintering between 650° and 800°C under an oxygen atmosphere. The permittivity of these compounds varies from ∼30 to ∼54, the Q × f value from 1.100 to 41.000 GHz (∼5 GHz), and the temperature coefficient of resonant frequency from −43 to −144 ppm/K. Bi 6 Te 2 O 15 and 7Bi 2 O 3 ·2TeO 2 do not react with silver, and, therefore, they have the potential to be used for applications in low‐temperature cofired ceramic (LTCC) technology.
Wax-Out Cryo-trapping: A New Trap-Filling Process in Fluid Migration to Oilfields (2022)

Oilfield reservoirs can contain a large variety of hydrocarbons from dry natural gas to tar. Chemical processes associated with kerogen formation and catagenesis, phase changes, and chromatographic separation in migration and in-reservoir fluid processes acting in geologic time all play important roles in determining the type of hydrocarbon in oilfield reservoirs. In the South China Sea, there are a large number of reservoirs that contain fluids of very unusual properties characterized by a high wax content and possessing very little solution gas and also missing the gasoline fraction. A new mechanism of trap filling associated with solid wax formation in migration (and called wax-out cryo-trapping) has been proposed to account for these unusual reservoir fluids. Here, various chemical processes are examined that may contribute to these unusual fluids. Specifically, conventional gas–liquid phase transitions known in migration are considered. The effects of biodegradation are also considered. The conclusion is that the wax-out cryo-trapping mechanism of trap filling is likely correct and adds an important new chemical process that can dramatically impact the composition of oilfield reservoirs.
High-frequency response of polymer shell contrast agents (2006)

Ultrasound contrast agents were originally designed for use at low MHz frequencies; however, recent experimental evidence suggests that many of these agents may also be useful for contrast imaging at frequencies above 20 MHz. Three polymer shelled agents (mean diameters of 0.56, 1.1, and 3.4 μm) from POINT Biomedical were investigated to determine their optimal high-frequency responses. A flow phantom was constructed to restrict the flow of a dilute contrast agent solution to a small volume. The focus of a 40-MHz single-element transducer from a Visual Sonics V770 was positioned within the flow phantom. Radio-frequency backscatter data from individual contrast agents were digitized under a variety of pulse durations (1–15 cycles) and pressure levels (1.4–7.6 MPa). Echo signals from individual bubbles were windowed, and spectra were calculated. Each of the POINT agents reflected energy at the 40-MHz fundamental; however, only the 1.1-μm-diameter agent displayed characteristics of a harmonic response under longer excitations (15 cycle) and medium pressure settings (2.5 to 5 MPa). Experimental results were compared to theoretical calculations for the case of the polymer shell remaining intact during excitation and for free gas nuclei that result from a ruptured shell.
Electric Ultra Fast Charging Stations: a Real Case Study (2021)

The number of Plug-in Electric Vehicles (PEVs) available on the car market is continuously growing. The electrification of the mobility is definitely related to the diffusion of the charging infrastructures widely distributed on the territory. Indeed, PEV owners request for charging stations able to offer features adequate to the expectations. They are expected to be able to recharge vehicle’s on-board battery in a ten of minutes. In this paper, Ultra Fast Charging Stations (UFCSs) are investigated. The stations are discussed in terms of electric schemes and modalities of control. There is a focus on components, systems, state variable and security level. Moreover, the UFCS realized at the University of Naples Federico II is highlighted. The lab prototype is discussed in terms of configuration and rated values. The results of some numerical tests are carried out. They point out both the main features of the charging slots and the requirements of load emulators for UFCS.
Rhodium(I) Complexes of Macrocyclic Tetradentate Thioethers (1976)

Reduction of the rhodium(III) complexes of the tetradentate macrocyclic thioethers 1,4,8,11 -tetrathiacyclotetradecane (TTP) and 13,14-benzo-l,4,8,11-tetrathiapentadecane (TTX) produces four-coordinate, cationic Rh(TTP)+ and Rh(TTX)+. The anions are not coordinated in [Rh(TTP)]X, X = ClO4-, PF6-, BF4-, NCS-, I-, or Br-. Furthermore, Rh(TTP)+ does not react with electron-pair donors including back-bonding ligands like C2H4, CO, and PPh3. Rh(TTP)+ does, however, combine with many eltctrophiles including BF3, SO2, NO+, O2, TCNE, and H+. Thus, it is a substantial nucleophile. Rh(TTP)+ undergoes oxidative addition with CH3I, C6H5-CH2Br, and thereby increasing both the coordination number and the oxidation state of Rh by two; however, it fails to react with H2.
Hybrid Broadcast-Unicast distribution of Mobile TV over 3G Networks (2006)

Several mobile operators have already launched MobileTV services in their network. Although traditionally delivered over broadcast those services are delivered over uni-cast today. With the introduction of MBMS during 2007/2008 cellular broadcast will become an alternative transport option. In this paper we present simulation results which show that from a radio resource perspective an optimal cellular TV distribution system should not allocate broadcast resources to all TV channels. Instead only channels with high viewing probability should be delivered over broadcast, all others should be offered "on-demand" over unicast
CENTRAL RETINAL ARTERY OCCLUSION IN A PATIENT WITH FIBROMUSCULAR DYSPLASIA (2004)

From the *Department of Ophthalmology, Osaka Medical College, and the †Department of Ophthalmology, Yodogawa Christian Hospital, Osaka, Japan. Presented at the 56th Congress of Clinical Ophthalmology of Japan, September, 2002, Morioka, Japan. None of the authors have any proprietary interests in any aspects of this paper. Reprint requests: Tatsu Sawada, MD, Department of Ophthalmology, Osaka Medical College, 2-7 Daigaku- cho, Takatsuki-shi, Osaka 569-8686, Japan; e-mail: [email protected]
Complex-Valued Frequency Selective Extrapolation for Fast Image and Video Signal Extrapolation (2010)

Signal extrapolation tasks arise in miscellaneous manners in the field of image and video signal processing. But, due to the widespread use of low-power and mobile devices, the computational complexity of an algorithm plays a crucial role in selecting an algorithm for a given problem. Within the scope of this contribution, we introduce the complex-valued Frequency Selective Extrapolation for fast image and video signal extrapolation. This algorithm iteratively generates a generic complex-valued model of the signal to be extrapolated as weighted superposition of Fourier basis functions. We further show that this algorithm is up to 10 times faster than the existent real-valued Frequency Selective Extrapolation that takes the real-valued nature of the input signals into account during the model generation. At the same time, the quality which is achievable by the complex-valued model generation is similar to the quality of the real-valued model generation.
Safety, tolerability and pharmacodynamics of a skeletal muscle activator in amyotrophic lateral sclerosis (2012)

This study was designed to evaluate the safety and tolerability of single doses of CK-2017357, an orally bioavailable fast skeletal muscle troponin activator, in patients with amyotrophic lateral sclerosis (ALS), and to explore pharmacodynamic markers related to strength, endurance, and function. Sixty-seven patients with ALS received single doses of placebo, CK-2017357 at 250 mg and 500 mg in random order, separated by one week. Safety measures assessments were performed, as well as tests of pulmonary function, limb muscle strength and endurance, and global impression of change. Pharmacokinetics of both CK-2017357 and riluzole were studied. Sixty-three patients completed all three dosing periods. CK-2017357 was well tolerated, with dizziness and general fatigue being the most frequent adverse events. Both patients and investigators perceived a dose-dependent benefit of CK-2017357 as measured by global impression of change. Maximum voluntary ventilation and submaximal handgrip endurance also improved. Only small changes were seen in maximal strength. In conclusion, single doses of 250 mg and 500 mg of CK-2017357 were safe and well tolerated by patients with ALS. Measures of endurance appear to be improved in a dose-related fashion, and both patients and investigators perceived a global benefit. Further study of this agent is warranted.
Absolute Configurations of Naturally Occurring Quinones: Ventilagone and Dunnione (2006)

Low-temperature determinations of the crystal structures of the naturally occurring quinones ventilagone (as its p-bromobenzyl ether) and dunnione (as its p-bromophenylhydrazone) permit the assignment of their absolute configurations as (1R,3S)-7,10-dihydroxy-1,3,8-trimethyl-3,4,6,9-tetrahydro-1H-naphtho[2,3-c]-pyrane-6,9-dione 1 and (2R)-2,3-dihydro-2,3,3-trimethylnaphtho[1,2-b]furan-4,5-dione 2.
TRPA channels distinguish gravity sensing from hearing in Johnston's organ (2009)

Although many animal species sense gravity for spatial orientation, the molecular bases remain uncertain. Therefore, we studied Drosophila melanogaster, which possess an inherent upward movement against gravity-negative geotaxis. Negative geotaxis requires Johnston's organ, a mechanosensory structure located in the antenna that also detects near-field sound. Because channels of the transient receptor potential (TRP) superfamily can contribute to mechanosensory signaling, we asked whether they are important for negative geotaxis. We identified distinct expression patterns for 5 TRP genes; the TRPV genes nanchung and inactive were present in most Johnston's organ neurons, the TRPN gene nompC and the TRPA gene painless were localized to 2 subpopulations of neurons, and the TRPA gene pyrexia was expressed in cap cells that may interact with the neurons. Likewise, mutating specific TRP genes produced distinct phenotypes, disrupting negative geotaxis (painless and pyrexia), hearing (nompC), or both (nanchung and inactive). Our genetic, physiological and behavioral data indicate that the sensory component of negative geotaxis involves multiple TRP genes. The results also distinguish between different mechanosensory modalities and set the stage for understanding how TRP channels contribute to mechanosensation.
A Note on Threshold Schemes with Disenrollment (2003)

Blakley, Blakley, Chan and Massey conjectured a lower bound on the entropy of public broadcast in a threshold scheme with disenrollment capability. In this paper, we first show that the con- jecture need not be true in general. Then we estab- lish a tight lower bound on the entropy of public in- formation by introducing one property to the defini- tion of threshold schemes with disenrollment. We also present a scheme that achieves the lower bound.
Metabolism is an Important Route of Pentamidine Elimination in the Rat: Disposition of14C‐Pentamidine and Identification of Metabolites in Urine Using Liquid Chromatography‐Tandem Mass Spectrometry (1995)

This study assesses the contribution of metabolism for the disposition of pentamidine in the rat. With the use of 14C-labelled compound, the excretion of radioactivity in urine and faeces has been studied in four rats during 44 days after a single intravenous injection of the drug. The urinary and faecal excretion of the radioactivity were of equal importance; 22 +/- 2% (mean +/- S.D.) and 25 +/- 4% being detected in urine and faeces, respectively. The activity in organs and tissues at 44 days after drug administration was also measured and amounted to 21 +/- 5% of the administered dose. Using HPLC the proportion of metabolites in urine in relation to unchanged pentamidine increased with time after dose, being 76 +/- 15% (mean +/- S.D.) of the total excreted radioactivity on day 1 and 97 +/- 1% on day 6. HPLC--tandem mass spectometry was used for identification of metabolites in urine obtained from four rats given unlabelled pentamidine. Using synthetic reference compounds and the selective MS/MS mode four oxidized metabolites of pentamidine were identified either by direct injection into the system or by analyses of extracted urine. Thus, a substantial part of pentamidine is excreted as metabolites in urine.
Long working distance incoherent interference microscope (2023)

A full-field imaging, long working distance, incoherent interference microscope suitable for three-dimensional imaging and metrology of MEMS devices and test structures on a standard microelectronics probe station. A long working distance greater than 10 mm allows standard probes or probe cards to be used. This enables nanometer-scale 3-dimensional height profiles of MEMS test structures to be acquired across an entire wafer while being actively probed, and, optionally, through a transparent window. An optically identical pair of sample and reference arm objectives is not required, which reduces the overall system cost, and also the cost and time required to change sample magnifications. Using a LED source, high magnification (e.g., 50.times.) can be obtained having excellent image quality, straight fringes, and high fringe contrast.