gebhart/patrepeval huggingface dataset:
A system-level circuit model for multi- and single-chip CPUs (1987)

This report will detail a system level circuit model that has been used to predict the performance of microprocessors, gate arrays, and mainframe computers implemented in several IC technologies. Comparisons have been made on the basis of clock frequency, power dissipation and chip/module sizes. Predictions indicate that in ten years a 0.7μm CMOS micro-processor with 6-million transistors will execute 30-60 MIPS.
Meditation and neurodegenerative diseases (2013)

Neurodegenerative diseases pose a significant problem for the healthcare system, doctors, and patients. With an aging population, more and more individuals are developing neurodegenerative diseases and there are few treatment options at the present time. Meditation techniques present an interesting potential adjuvant treatment for patients with neurodegenerative diseases and have the advantage of being inexpensive, and easy to teach and perform. There is increasing research evidence to support the application of meditation techniques to help improve cognition and memory in patients with neurodegenerative diseases. This review discusses the current data on meditation, memory, and attention, and the potential applications of meditation techniques in patients with neurodegenerative diseases.
Concepts for solution-processable OLED materials at Merck (2011)

Drastic performance increase and accelerated progress in organic light-emitting diodes from solutions are shown using solution-processable small molecules based on the core structures of vacuum-evaporable materials. Systematic modification of small-molecule materials toward better processability from solutions at identical electro-optical properties is shown. This is demonstrated to lead to a significant improvement in the device performance.
Regrowth-Free GaN-Based Complementary Logic on a Si Substrate (2020)

This paper demonstrates a complementary logic circuit (an inverter) on a GaN-on-Si platform without the use of regrowth technology. Both n-channel and p-channel GaN transistors are monolithically integrated on a GaN/AlGaN/GaN double heterostructure. N-channel FETs show enhancement-mode (E-mode) operation with a threshold voltage around 0.2 V, ON-OFF current ratio of 107 and RON of 6 Ω · mm, while the p-channel FETs show E-mode operation with Vth of -1 V, ON-OFF current ratio of 104 and RON of 2.3 kQ·mm. Complementary logic inverters fabricated with this technologyyield a record maximum voltage gain of ~27 V/V at an input voltage of 0.59 V with VDD = 5 V. Excellent transfer characteristics have been obtained up to 300°C operating temperatures, which demonstrates the suitability of this technology for low-power high-temperature electronic applications.
Nanofiber Fuel Cell Electrodes II. In-Situ Performance and Durability Studies (2013)

Abstract not Available.
Holographic photopolymerization: A route to passive and active optical elements (2003)

Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text T. Bunning, "Holographic photopolymerization: A route to passive and active optical elements," in Frontiers in Optics, OSA Technical Digest (CD) (Optica Publishing Group, 2003), paper MG4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
AGN 191976: A Novel Thromboxane A 2 -Mimetic with Ocular Hypotensive Properties (1995)

The possible subdivision of thromboxane A2-sensitive (TP) receptors is currently a controversial subject. We report herein on a novel thromboxane A2 mimetic, AGN 191976, which has almost identical pharmacological activity to the well-characterized prostaglandin H2/thromboxane A2 (PGH2/TxA2) mimetic U-46619, but its effects on intraocular pressure are quite distinct from U-46619. Prostanoid receptor activity was determined in vitro using different smooth muscle assays and platelets. Intraocular pressure was measured tonometrically in ocular normotensive Beagle dogs and Cynomolgus monkeys. Conjunctival microvascular permeability was determined in guinea pigs. Despite closely resembling U-46619 as a potent and selective TP receptor agonist, AGN 191976 was a potent ocular hypotensive in dogs and monkeys whereas U-46619 did not lower IOP in either species. The ocular hypotensive effect of AGN 191976 in dogs was attenuated by pretreatment with the TP receptor antagonist SQ 29548. Thus, the ocular hypotensive effects of AGN 191976 are consistent with TP receptor stimulation. Both TxA2-mimetics caused plasma leakage in the guinea pig conjunctiva. The disparate activities of U-46619 and AGN 191976 in our studies suggest the existence of heterogeneous populations of TP-receptors in the eye.
Directionally Guided Angiogenesis Within Extruded Type I Collagen Filaments In Vivo (2006)

Two types of crosslinked extruded type I collagen filaments were developed and characterized for implantation into canine knee joints to achieve anterior cruciate ligament (ACL) regeneration. Type A filaments were crosslinked with glutaraldehyde. Type B filaments were crosslinked with glyceraldehyde and treated with heparin and basic fibroblast growth factor (bFGF). Microscopic evaluation of the filaments revealed a gradient in the degree of crosslinking, with the surface of the filaments more highly crosslinked than the interior. The heterogeneous nature of the crosslinking was demonstrated by complementary methods using bright-field and polarized light microscopy imaging of differentially stained histological sections. In vivo, in the canine model of ACL replacement, the interior of the Type A filaments was degraded or resorbed well before the surface, thus creating collagen tubes through which new capillary channels developed. This phenomenon was not observed for the Type B collagen filaments that were degraded or resorbed from the periphery of each filament. The in vivo behavior of individual collagen filament types is correlated with the fabrication methods. The results suggest a novel method with which to achieve directionally guided angiogenesis (The J Histotechnol 29:267, 2006).Submitted October 1, 2006; accepted with revisions November 2, 2006
Development of a Socketed Foundation for Cable Barrier Posts – Phase I (2012)

Four socketed foundation designs were evaluated for use as a new reusable base for high-tension, cable barrier systems. Each foundation was a reinforced concrete cylindrical shape. The top of the foundation had an open steel tube to accept the post during installation. The four foundation designs were installed in sand and subjected to dynamic component testing in order to simulate a weak/saturated soil and evaluate maximum displacements during impact events. An S4x7.7 (S102x11.5) post was selected for each test assembly after a review of the current Federal Highway Administration-accepted, high-tension cable barrier systems revealed the section to be the strongest and most critical post. Both the 24 in. (610 mm) and 36 in. (914 mm) deep foundations rotated through the soil and were deemed too shallow to prevent excessive deformations. The other two assemblies, both 60 in. (1,524 mm) deep, fractured during the impact event. As a result, the 60 in. (1,524 mm) deep configurations were deemed too weak to sustain the full load capacity of the S4x7.7 (S102x11.5) post. Further, the displacement for the 60 in. (1,524 mm) deep foundations could not be determined due to premature fracture. Therefore, none of the four socketed foundation configurations was found to be acceptable and further development and testing was recommended.
Effects of Ge Content on the Oxidation Behavior of Poly-Si[sub 1−x]Ge[sub x] Layers for Gate Electrode Application (2001)

Oxidation characteristics of nonpatterned and patterned poly-SiGe layers were evaluated to confirm the feasibility for the application of poly-SiGe to the gate electrode. Characterization of poly-SiGe after oxidation was performed using atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), cross-sectional transmission electron microscopy (TEM), and energy-dispersive X-ray spectroscopy (EDS). The oxide thickness on poly-SiGe layer increased with increasing Ge content, while that on poly-SiGe (Ge 20%) sample was comparable to that of poly-Si (Ge 0%). When the Ge content was more than 40%, two different oxide layers were observed on poly-SiGe. Intensive analyses revealed that the oxide layers were composed of -rich mixed oxide and -rich mixed oxide For the patterned poly-SiGe sample, the oxidation characteristics were similar to those of nonpatterned sample. The best sidewall oxide profile was obtained in poly-SiGe (Ge 20%) sample. Because the sidewall oxide thickness is too thick for poly-SiGe sample with more than 40% of Ge, poly-SiGe (Ge 20%) is believed to be the most suitable candidate for gate electrode material. © 2001 The Electrochemical Society. All rights reserved.
RUGGED BOARD-TO-BOARD OPTICAL INTERCONNECT WITH CLOSED-LOOP MICROLENS SCANNER (2008)

This paper discusses a free-space optical interconnect system capable of dynamic closed-loop optical alignment using a microlens scanner and a proportional integral and derivative (PID) controller. Electrostatic microlens scanners based on combdrive actuators are designed, fabricated, and characterized with vertical cavity surface emitting lasers (VCSELs) for adaptive optical beam tracking in the midst of mechanical vibration noises. We demonstrate optical beam positioning noise reduction of approximately 20 dB with a 400 Hz bandwidth in the presence of up to a 3g (g = 9.8m/s 2 ) vibration. Lens Vup V0 V0 Vdown Vleft Vright Lens Vup V0 V0 Vdown Vleft Vright (a) X-axis motion Lens Vup V0 V0 Vdown Vleft Vright Lens Vup V0 V0 Vdown Vleft Vright (b) Y-axis motion Figure 2: Scanning modes of operation for two orthogonal axes. Electrical isolation trenches are indicated by red lines.
Bipyridine-based iridium(iii) triplet emitters for organic light-emitting diodes (OLEDs): application and impact of phenyl substitution at the 5′-position of the N-coordinating pyridine ring (2019)

Three blue phosphorescent homoleptic iridium(iii) complexes based on a bipyridine ligand were synthesized. The structures of these Ir(C^N)3 analogues were determined by single-crystal X-ray diffraction analysis. Two geometrical isomers, facial and meridional, formed as the major products, and the ratio of the products depended on the substituents. The photophysical and electrochemical properties of the complexes were analyzed, and they were used as dopants for the fabrication of phosphorescent organic light-emitting diodes (PHOLEDs). The dependence of current density on dopant concentration in the devices, as well as their external quantum efficiencies and current efficiencies, were evaluated. All complexes exhibited intense, sky-blue phosphorescent emission at λmax = 479, 484 and 488 nm, and the absolute quantum efficiencies in the thin films were high at 0.72, 0.75 and 0.81. A maximum current efficiency of 39.8 cd A-1 and an external quantum efficiency (EQE) of 14.9% were obtained, which signified superior performance among blue phosphorescent organic light-emitting diodes. High efficiencies of 39.2 cd A-1 and 14.0% EQE were still achieved at a luminance of 1000 cd m-2.
Future perspectives in melanoma research: meeting report from the "Melanoma Bridge", Napoli, December 5th-8th 2013 (2014)

The fourth "Melanoma Bridge Meeting" took place in Naples, December 5 to 8th, 2013. The four topics discussed at this meeting were: Diagnosis and New Procedures, Molecular Advances and Combination Therapies, News in Immunotherapy, and Tumor Microenvironment and Biomarkers.
Precise 6D RTK Positioning System for UAV-based Near-Field Antenna Measurements (2020)

Near-field antenna measurements with an Unmanned Aerial Vehicle (UAV) require an accurate 3D position and 3D attitude information. In this paper, we estimate the position and velocity of the UAV, the quaternion that describes its attitude, the carrier phase integer ambiguities related to both the attitude and position, and the accelerometer bias with a Kalman filter. The raw measurements were obtained from the ANavS Multi-Sensor RTK module with its 3 Multi-frequency, Multi-GNSS receivers and a MEMS-based Inertial Measurement Unit (IMU). We used the UAV of AeroXess to validate our method and achieved a centimeter-level positioning accuracy in both static and kinematic conditions.
A finite-difference algorithm to retrieve finite-difference modeled elastic waves at the free surface (2018)

Although drawbacks exist, finite-difference simulations remain a popular method to compute solutions to the seismic wave equation. One such drawback, compared to other modeling methods such as the spectral element method, is that staggered finite-difference computations cannot simultaneously output stress and velocity constituents at the free surface. We present an algorithm to obtain the response of all wavefield constituents at the free surface, using two additional, localized, finite-difference simulations. The method is based on the representation theorem, and requires the presence of a homogeneous layer between the free surface and the virtual recording surface just below it. The method is demonstrated on a simple acoustic and elastic model. Artifacts upon timereversal currently obstruct a clean retrieval of first arrivals, and the removal of these artifacts is the subject of further research. Presentation Date: Wednesday, October 17, 2018 Start Time: 8:30:00 AM Location: 205A (Anaheim Convention Center) Presentation Type: Oral
Binding of the bacteriophage T4 regA protein to mRNA targets: an initiator AUG is required (1990)

Bacteriophage T4 regA protein translationally represses the synthesis of a subset of early phage-induced proteins. The protein binds to the translation initiation site of at least two mRNAs and prevents formation of the initiation complex. We show here that the protein binds to the translation initiation sites of other regA-sensitive mRNAs. Analysis of mRNA binding by filtration and nuclease protection assays shows that AUG is necessary but not sufficient for specific binding of regA protein to its mRNA targets. Anticipating the need for large quantities of regA protein for structural studies to further define the regA protein-RNA ligand interaction, we also report cloning the regA gene into a T4 overexpression system. The expression of regA protein in uninfected E. coli is lethal, so in our system regA driven by a strong T7 promoter is sequestered in a T4 phage until 'induction' by phage infection is desired. We have replaced the regA sensitive wild-type ribosome binding site with a strong insensitive ribosome binding site at an optimal distance from the regA initiation codon for maximizing expression. We have obtained large amounts of regA protein.
Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA (2014)

Current antiviral agents can control but not eliminate hepatitis B virus (HBV), because HBV establishes a stable nuclear covalently closed circular DNA (cccDNA). Interferon-α treatment can clear HBV but is limited by systemic side effects. We describe how interferon-α can induce specific degradation of the nuclear viral DNA without hepatotoxicity and propose lymphotoxin-β receptor activation as a therapeutic alternative. Interferon-α and lymphotoxin-β receptor activation up-regulated APOBEC3A and APOBEC3B cytidine deaminases, respectively, in HBV-infected cells, primary hepatocytes, and human liver needle biopsies. HBV core protein mediated the interaction with nuclear cccDNA, resulting in cytidine deamination, apurinic/apyrimidinic site formation, and finally cccDNA degradation that prevented HBV reactivation. Genomic DNA was not affected. Thus, inducing nuclear deaminases-for example, by lymphotoxin-β receptor activation-allows the development of new therapeutics that, in combination with existing antivirals, may cure hepatitis B.
Dynamics of breeding containers formation of Aedes aegypti (Diptera: Culicidae) Larvae (2006)

We report the construction and simulation of a mathematical model type SIRS (Susceptible-Infective-Removed- Susceptible). Four differential equations show the effects of the parameters θ (cultural control rate) and ϕ (rate of breeding containers protected for some time by application of biological or chemical treatment) into the control of infective breeding container by oviposition. The breeding control influences directly the increase of mosquitos number related to environmental aspects represented by Sin 2 function. An integrated program of cultural control and conventional (chemical/biological) treatment can diminish the number of breeding containers n then the population of mosquitos.
Learning-based Relational Object Matching Across Views (2023)

Intelligent robots require object-level scene understanding to reason about possible tasks and interactions with the environment. Moreover, many perception tasks such as scene reconstruction, image retrieval, or place recognition can benefit from reasoning on the level of objects. While keypoint-based matching can yield strong results for finding correspondences for images with small to medium view point changes, for large view point changes, matching semantically on the object-level becomes advantageous. In this paper, we propose a learning-based approach which combines local keypoints with novel object-level features for matching object detections between RGB images. We train our object-level matching features based on appearance and inter-frame and cross-frame spatial relations between objects in an associative graph neural network. We demonstrate our approach in a large variety of views on realistically rendered synthetic images. Our approach compares favorably to previous state-of-the-art object-level matching approaches and achieves improved performance over a pure keypoint-based approach for large view-point changes.
Porphyromonas gingivalis induce apoptosis in human gingival epithelial cells through a gingipain-dependent mechanism (2009)

The present study provides evidence that live, but not heat-killed, P. gingivalis can induce apoptosis after 24 hours of challenge in primary human gingival epithelial cells. Either arginine or lysine gingipains are necessary and sufficient factors in P. gingivalis elicited apoptosis.
Retinal-Vein Occlusion (2010)

This article reviews the typical presentations of branch and central retinal-vein occlusion and the strategies for their management, with particular attention to the roles of laser therapy, ophthalmic glucocorticoids, and anti-VEGF therapies.
Genomic analysis of liver cancer unveils novel driver genes and distinct prognostic features (2018)

<b>Objective:</b> Hepatocellular carcinoma (HCC) is a highly heterogeneous disease with a dismal prognosis. However, driver genes and prognostic markers in HCC remain to be identified. It is hoped that in-depth analysis of HCC genomes in relation to available clinicopathological information will give rise to novel molecular prognostic markers. <b>Methods:</b> We collected genomic data of 1,061 HCC patients from previous studies, and performed integrative analysis to identify significantly mutated genes and molecular prognosticators. We employed three MutSig algorithms (MutSigCV, MutSigCL and MutSigFN) to identify significantly mutated genes. The GISTIC2 algorithm was used to delineate focally amplified and deleted genomic regions. Nonnegative matrix factorization (NMF) was utilized to decipher mutational signatures. Kaplan-Meier survival and Cox regression analyses were used to associate gene mutation and copy number alteration with survival outcome. Logistic regression model was applied to test association between gene mutation and mutational signatures. <b>Results:</b> We discovered 11 novel driver genes, including <i>RNF213</i>, <i>VAV3</i> and <i>TNRC6B</i>, with mutational prevalence ranging from 1% to 3%. Seven mutational signatures were also identified in HCC, some of which were associated with mutations of classical driver genes (e.g., <i>TP53</i>, <i>TERT</i>) as well as alcohol consumption. Focal amplifications of <i>TERT</i> and other druggable targets, including <i>AURKA</i>, were also revealed. Targeting AURKA by a small-molecule inhibitor potently induced apoptosis in HCC cells. We further demonstrated that HCC patients with <i>TERT</i> amplification displayed shortened overall survival independent of other clinicopathological parameters. In conclusion, our study identified novel cancer driver genes and prognostic markers in HCC, reiterating the translational importance of omics data in the precision medicine era.
WSi0.11 Schottky gates for GaAs metal semiconductor field-effect transistors (1987)

Schottky gates for self-aligned GaAs metal semiconductor field-effect transistors (MESFETs) have been formed by dc magnetron sputtering of WSi0.11 onto sputter-cleaned GaAs surfaces. The WSi0.11/GaAs diodes showed good current-voltage and capacitance-voltage characteristics after annealing at 800 °C. Schottky barrier heights measured by current-voltage were φI-VB ≂0.73 eV with an ideality factor n≂1.14 for large diodes and φI-VB ≂0.67 eV with n≂1.3 for 1×10 μm gates without a self-aligned n+ implant. The n+ self-aligned implant was found to cause leakage current, which was interpreted as a parallel small-area, low-barrier diode at the gate edge. FETs formed with this gate material showed good threshold voltage uniformity with a standard deviation as low as 31 mV for 1 μm enhancement-mode FETs and 49 mV for 1 μm depletion-mode FETs on a 51-mm wafer.
PCH-2 regulates Caenorhabditis elegans lifespan (2015)

Components or downstream targets of many signaling pathways such as Insulin/IGF-1 and TOR, as well as genes involved in cellular metabolism and bioenergetics can extend worm lifespan 20% or more. The C. elegans gene pch-2 and its homologs, including TRIP13 in humans, have been studied for their functions in cell mitosis and meiosis, but have never been implicated in lifespan regulation. Here we show that over-expression of TRIP13 in human fibroblasts confers resistance to environmental stressors such as UV radiation and oxidative stress. Furthermore, pch-2 overexpression in C. elegans extends worm lifespan, and enhances worm survival in response to various stressors. Conversely, reducing pch-2 expression with RNAi shortens worm lifespan. Additional genetic epistasis analysis indicates that the molecular mechanism of pch-2 in worm longevity is tied to functions of the sirtuin family, implying that pch-2 is another chromatin regulator for worm longevity. These findings suggest a novel function of the pch-2 gene involved in lifespan determination.
Twist-angle dependence of moiré excitons in WS2/MoSe2 heterobilayers (2020)

Moiré lattices formed in twisted van der Waals bilayers provide a unique, tunable platform to realize coupled electron or exciton lattices unavailable before. While twist angle between the bilayer has been shown to be a critical parameter in engineering the moiré potential and enabling novel phenomena in electronic moiré systems, a systematic experimental study as a function of twist angle is still missing. Here we show that not only are moiré excitons robust in bilayers of even large twist angles, but also properties of the moiré excitons are dependant on, and controllable by, the moiré reciprocal lattice period via twist-angle tuning. From the twist-angle dependence, we furthermore obtain the effective mass of the interlayer excitons and the electron inter-layer tunneling strength, which are difficult to measure experimentally otherwise. These findings pave the way for understanding and engineering rich moiré-lattice induced phenomena in angle-twisted semiconductor van der Waals heterostructures.