gebhart/patrepeval huggingface dataset:
The Risk of Switch to Mania in Patients With Bipolar Disorder During Treatment With an Antidepressant Alone and in Combination With a Mood Stabilizer (2015)

Objective: This study examined the risk of antidepressant-induced manic switch in patients with bipolar disorder treated either with antidepressant monotherapy or with an antidepressant in conjunction with a mood stabilizer. Method: Using Swedish national registries, the authors identified 3,240 patients with bipolar disorder who started treatment with an antidepressant and had no antidepressant treatment during the previous year. Patients were categorized into those receiving antidepressant monotherapy and those receiving an antidepressant plus a mood stabilizer. A within-individual design was used to control for confounding by disorder severity, genetic makeup, and early environmental factors. Cox regression analyses conditioned on individual were used to compare the rate of mania 0–3 months and 3–9 months after the start of antidepressant treatment with a preceding non-treatment period. Results: Nearly 35% of the patients were treated with antidepressant monotherapy. The increased risk of treatment-emergent mania was confined to patients on antidepressant monotherapy (hazard ratio=2.83, 95% CI=1.12, 7.19). Among patients treated with a concurrent mood stabilizer, no acute change in risk of mania was observed during the 3 months after the start of antidepressant treatment (hazard ratio=0.79, 95% CI=0.54, 1.15), and a decreased risk was observed during the period 3–9 months after treatment initiation (hazard ratio=0.63, 95% CI=0.42, 0.93). Conclusions: In this national registry study, antidepressant monotherapy was associated with an increased risk of mania. However, no risk of mania was seen in patients receiving an antidepressant while treated with a mood stabilizer. The results highlight the importance of avoiding antidepressant monotherapy in the treatment of bipolar disorder. Reprinted with permission from the American Journal of Psychiatry 2014; 171:1067–1073
Reduction of myocardial oxygen demand by controlling heart rate and hemodynamics simultaneously by novel circulatory model (2011)

We were already capable of restoring automatically blood pressure, cardiac output, and left atrial pressure by an inotropic, a vasodilator, and volume infusion/a diuretic. Countermeasures for cardioprotection, however, should be integrated to improve the long-term outcomes. We established a full control of heart rate and examined if such a control was useful for decreasing cardiac oxygen consumption. Based on a simulation result, we conducted an animal experiment. In 7 dogs with acute heart failure, we treated hemodynamics, and then lowered heart rate. Compared to the treatment for hemodynamics alone, the addition of bradycardia decreased cardiac oxygen consumption. It was possible to maintain hemodynamics without sacrificing cardiac oxygen consumption.
Crowdsourcing Gold-HIT Creation at Scale: Challenges and Adaptive Exploration Approaches (Position Paper) (2013)

Gold HITs — Human Intelligence Tasks with known answers — are commonly used to measure worker performance and data quality in industrial applications of crowdsourcing. We suggest adaptive exploration as a promising approach for automated, scalable Gold HIT creation. We substantiate this with initial experiments in a stylized model.
Antiviral effects of deoxynojirimycin (DNJ)-based iminosugars in dengue virus-infected primary dendritic cells (2022)

Dendritic cells (DCs) are important targets for dengue virus (DENV) infection and play a significant role in the early immune response. Antiviral effects of iminosugars against DENV in primary cells have been demonstrated previously in monocyte-derived macrophages (MDMΦs). Given the important role played by DCs in innate immune defense against DENV, the antiviral effects of three deoxynojirimycin (DNJ) derivatives (NN-DNJ, EOO-DNJ and 2THO-DNJ) and a deoxygalactonojirimycin (DGJ) negative control were evaluated in DENV-infected primary human monocyte-derived immature DCs (imDCs). DNJ- but not DGJ-derivatives elicited antiviral activity in DENV-infected imDCs, similar to that observed in MDMΦs. The DNJ-derivatives inhibited DENV secretion in a dose-dependent manner. Endoplasmic reticulum (ER) α-glucosidase I inhibition by DNJ-derived iminosugars, at concentrations of 3.16 μM, correlated with a reduction in the specific infectivity of virions that were still secreted, as well as a reduction in DENV-induced tumour necrosis factor alpha secretion. This suggests iminosugar-mediated ER α-glucosidase I inhibition may give rise to further benefits during DENV infection, beyond the reduction in viral secretion associated with ER α-glucosidase II inhibition.
Animal models of sports‐related head injury: bridging the gap between pre‐clinical research and clinical reality (2014)

Sports-related head impact and injury has become a very highly contentious public health and medico-legal issue. Near-daily news accounts describe the travails of concussed athletes as they struggle with depression, sleep disorders, mood swings, and cognitive problems. Some of these individuals have developed chronic traumatic encephalopathy, a progressive and debilitating neurodegenerative disorder. Animal models have always been an integral part of the study of traumatic brain injury in humans but, historically, they have concentrated on acute, severe brain injuries. This review will describe a small number of new and emerging animal models of sports-related head injury that have the potential to increase our understanding of how multiple mild head impacts, starting in adolescence, can have serious psychiatric, cognitive and histopathological outcomes much later in life. Sports-related head injury (SRHI) has emerged as a significant public health issue as athletes can develop psychiatric and neurodegenerative disorders later in life. Animal models have always been an integral part of the study of human TBI but few existing methods are valid for studying SRHI. In this review, we propose criteria for effective animal models of SRHI. Movement of the head upon impact is judged to be of primary importance in leading to concussion and persistent CNS dysfunction.
ChemInform Abstract: ANGIOTENSIN‐CONVERTING ENZYME INHIBITORS: SYNTHESIS AND BIOLOGICAL ACTIVITY OF ACYLTRIPEPTIDE ANALOGS OF ENALAPRIL (1985)

Abstract Synthetisiert und als Inhibitoren von ACE (angiotensin converting enzyme) geprüft werden die Analoga (VII) und (VIII).
A broadband THz imager in a low-cost CMOS technology (2011)

The paper demonstrates a complete acquisition chain of a 300GHz to 1THz image sensor with on-chip multiplexing in a 0.13μm bulk silicon CMOS technology. The pixel consumes less than 100μW and has a responsivity of 90kV/W at 300GHz and of 1.8kV/W at 1.05THz respectively. High resolution and contrast THz images revealing the inner structure of tree leaves are presented. These results show that multi-frequency and room temperature imaging systems are possible in cost-effective CMOS technologies.
Calculated and measured uv reflectivity of SiC polytypes (1994)

A systematic study of the vacuum uv reflectivity (4--10 eV) for an electric field perpendicular to the c-axis is presented for SiC polytypes. Experimental results for the 4H, 15R, 6H, and 3C SiC polytypes are compared to theoretical calculations within the local-density approximation in conjunction with a muffin-tin-orbital basis set for the 2H, 4H, 6H, and 3C polytypes. Agreement to \ensuremath{\sim}0.2 eV is obtained between theoretical and experimental peak positions assuming a single, k-point-, energy-, and polytype-independent gap correction, the value of which agrees well with recent calculations based on Hedin's GW approximation. The main features and their trends with degree of hexagonality of the polytype are interpreted in terms of interband transitions involving extended regions in the Brillouin zone where valence and conduction bands are nearly parallel.
Nouvelles strategies diagnostiques dans les maladies biliopancreatiques (2000)

SCOPUS: ar.j
Joint Estimation of Linear and Non-linear Signal-to-Noise Ratio based on Neural Networks (2018)

A novel technique estimating ASE and non-linear SNR is presented. Our method is evaluated by simulations obtaining a std error of 0.23 dB for both ASE and non-linear SNR.
Enhanced Injury Theory: An Analytic Framework (1984)

nant with the state of the art to minimize the effect of accidents.' 8 The proper terminology for characterizing this theory is "enhanced injury" liability.' 9 In addition to that term, courts and commentators have described such accidents as involving "crashworthiness" 20 or a "second collision." 2 1 In many cases, courts have used the three terms interchangeably. 22In so doing, they have unintentionally masked the broad applicability 18. Id at 501-03.19.Courts have used this terminology in the following cases: Seese v. Volkswagenwerk,
Anion specific adsorption of carboxymethyl cellulose on cellulose (2023)

Integration of fiber modification step with modern pulp mill is a resource efficient way to produce functional fibers. Motivated by the need to integrate polymer adsorption with the current pulping system, anion-specific effects in Carboxymethylcellulose (CMC) adsorption have been studied. The QCM-D adsorption experiments revealed that the CMC adsorption to the cellulose model surface is prone to anion-specific effects. A correlation was observed between the adsorbed CMC and the degree of hydration of the co-ions present in the magnesium salts. The presence of chaotropic co-ion such as nitrate increased the adsorption of CMC on cellulose compared to the presence of the kosmotropic sulfate co-ion. However, anion-specificity was not significant in the case of salts containing zinc cations. The hydration of anions determines the distribution of ions at the interface. Chaotropic ions, such as nitrates, are likely to be distributed near the chaotropic cellulose surface, causing changes in the ordering of water molecules and resulting in greater entropy gain once released from the surface, thus increasing the CMC adsorption.
Production of a favorable calibration target for the determination of distortions of lenses in image processing (2019)

Lenses have a number of faults. The distortion is an error which has a negative effect especially in metrological applications. In extreme cases, distortion can also be visible to the naked eye. The distortion of lenses is a systematic error that can be corrected numerically. For this purpose, a target with a smaller local deviation is necessary. These targets are produced and measured with great effort. Especially for the area of large object fields the effort increases enormously. For this reason, no correction has been made for larger measuring ranges. In order to be able to apply a correction nevertheless, a compromise solution is required that produces a target with little effort, with which a correction becomes possible that is better than not applying any correction at all. Here, calibration targets were printed and examined with commercially available printers.
A 2.3nJ/frame Voice Activity Detector based audio front-end for context-aware System-on-Chip applications in 32nm CMOS (2012)

An audio front-end with Voice Activity Detection (VAD) hardware targeted for low-power embedded SoCs, featuring a 512pt FFT, programmable filters, noise floor estimator and a decision engine has been fabricated in 32nm CMOS. The dual-V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CC</sub> , dual-frequency design allows the core datapath to scale to near-threshold voltage, where power consumption is less than 50μW. At peak energy efficiency, the core can process audio data at 2.3nJ/frame - a 9.4X improvement over nominal voltage conditions.
Abstract B30: A phase 1 open label, dose-escalation trial evaluating the safety and tolerability of EF-022, macrophage activator, in subjects with advanced solid malignancies (2015)

Abstract Scientific background: Activated macrophages, present in excess during natural inflammatory responses, bear the potential to kill and eradicate cancer cells. Efranat has developed cancer immunotherapy based on macrophage activation using a plasma protein designated EF-022, a modified Vitamin D Binding Protein Macrophage Activator. Methods: We performed an open label single-center phase I study in patients diagnosed with inoperable, recurrent or metastatic malignant solid tumors, deemed incurable, and who have failed to respond to standard therapy or for whom no standard therapy is available. The dose-escalation study was comprised of three cohorts, each receiving intramuscular (IM) injections of EF-022, once weekly for two cycles of treatment. Each cycle consisted of 4 weekly injections. Three dose levels were evaluated: 100 ng, 500ng and 1000ng. Patients were followed for up to 12 months from the start of treatment. The primary study objectives were to determine the safety and tolerability and to define the dose-limiting toxicities (DLT) and maximum tolerated doses (MTD). Blood and tissue biopsies were obtained for pharmacodynamics evaluation. Results: 12 patients with solid tumors have been enrolled. Median age = 65; male: female = 5:7. Among 12 treated patients, the most frequent drug related adverse events were flu like symptoms and rash and were mostly grade 1 or 2; no serious adverse events (SAE) related to study drug were observed. No DLTs were observed. CT imaging performed at 8 weeks showed stable disease (SD) in 5/12 patients (cholangiocarcinoma, H&amp;N cancer, esophageal-gastric cancer, ovarian cancer and liposarcoma). 11 patients completed 57 days of treatment and 1 patient left the study after 1st cycle of treatment (29 days). Significant reduction in Tregs (CD4+CD127-CD25+) levels and increase in M1/M2 monocyte (CD14+HLA+ /CD16+CD163+) ratio in the blood was detected in most of the patients. In patients demonstrating SD an increase in the M1/M2 macrophage ratio (CD68+CD163-/ CD68+CD163+) was found at the tumor site. Conclusions: Treatment with EF-022 has an acceptable safety profile and resulted in disease stabilization in 42% of patients. Pharmacodynamics markers suggest a reduction of Tregs and increase of the M1/M2 ratio. These findings are being further explored in a dose expansion cohort. ClinicalTrials.gov Identifier: NCT02052492 Citation Format: Talia Golan, Raanan Berger, Aliza Ackerstein, Steve Raskin, Alexander M. Lesokhin, David Sidransky, Mark L. Levitt, Hana Gadassi, Uri Yogev, Michal Shahar. A phase 1 open label, dose-escalation trial evaluating the safety and tolerability of EF-022, macrophage activator, in subjects with advanced solid malignancies. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2015 Nov 5-9; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr B30.
Supplementary Figures S1-S2 from Dominant-Negative Histone H3 Lysine 27 Mutant Derepresses Silenced Tumor Suppressor Genes and Reverses the Drug-Resistant Phenotype in Cancer Cells (2023)

Supplementary Figures S1-S2 from Dominant-Negative Histone H3 Lysine 27 Mutant Derepresses Silenced Tumor Suppressor Genes and Reverses the Drug-Resistant Phenotype in Cancer Cells
Exact localization of acoustic reflectors from quadratic constraints (2011)

In this paper we discuss a method for localizing acoustic reflectors in space based on acoustic measurements on source-to-microphone reflective paths. The method converts Time of Arrival (TOA) and Time Difference of Arrival (TDOA) into quadratic constraints on the line corresponding to the reflector. In order to be robust against measurement errors we derive an exact solution for the minimization of a cost function that combines an arbitrary number of quadratic constraints. Moreover we propose a new method for the analytic prediction of reflector localization accuracy. This method is sufficiently general to be applicable to a wide range of estimation problems.
Unusual Ligand Discrimination by a Myoglobin Reconstituted with a Hydrophobic Domain-Linked Heme (2004)

New, reconstituted horse heart myoglobins possessing a hydrophobic domain at the terminal of the two heme propionate side chains were constructed. The O2 and CO bindings for the reconstituted deoxymyoglobins were examined in detail by laser flash photolysis and stopped-flow rapid mixing techniques. The artificially created domain worked as a barrier against exogenous ligand penetration into the heme pocket, whereas the bound O2 was stabilized in the reconstituted myoglobin as well as in the native one. In contrast, the CO dissociation rate for the reconstituted myoglobin increased by 20-fold compared to the native protein, suggesting that the incorporation of the hydrophobic domain onto the heme pocket perturbs the distal-site structure of the reconstituted myoglobin. As a result, the substantial ligand selectivity for the reconstituted myoglobin significantly increases in favor of O2 over CO with the M' value (= KCO/KO2) of 0.88, whereas, to the best of our knowledge, there is no myoglobin mutant in which the O2 affinity exceeds the CO one. The present work concludes that the O2 selectivity of myoglobin over CO is markedly improved by chemically modifying the heme propionates without any mutation of the amino acid residues in the distal site.
Initiation of electrically augmented flames (1971)

A study has been made of the voltage required to initiate an electrically augmented propane-air flame between a copper anode and a pointed graphite or tungsten cathode. The voltage was applied as a ramp input of less than 30 V S−1. The initiation voltage, which varied between 1200 and 2000 V, was measured at propane concentrations of 3·2 to 6·3% and electrode gaps of 0·4 to 1·8 cm, with total gas throughputs of between 525 and 1400 cm3 S−1.
Laser produced EUV light source development for HVM (2007)

We develop a laser produced plasma light source for high volume manufacturing (HVM) EUV lithography. The light source is based on a short pulse, high power, high repetition rate CO<sub>2</sub> master oscillator power amplifier (MOPA) laser system and a Tin droplet target. A maximum conversion efficiency of 4.5% was measured for a CO<sub>2</sub> laser driven Sn plasma having a narrow spectrum at 13.5 nm. In addition, low debris generation was observed. The CO<sub>2</sub> MOPA laser system is based on commercial high power cw CO<sub>2</sub> lasers. We achieve an average laser power of 3 kW at 100 kHz with a single laser beam that has very good beam quality. In a first step, a 50-W light source is developing. Based on a 10-kW CO<sub>2</sub> laser this light source is scalable to more than 100 W EUV in-band power.
Ring syntheses of the four N-methylprotoporphyrin isomers and of related N-methyl and N,N′-dimethylporphyrins (1991)

Total syntheses of the four isomeric N-methylprotoporphyrin IX dimethyl esters have been achieved by the MacDonald and tripyrrene/a,c-biladiene routes using appropriate N-methylpyrroles and N-methyldipyrromethanes as intermediates. The syntheses of related N-methyl and N,N′-dimethylporphyrins have also been achieved by the MacDonald route.
Temporal evolution of atmosphere pressure plasma jets driven by microsecond pulses with positive and negative polarities (2014)

Current-voltage characteristics, discharge images, and optical spectra of atmospheric pressure plasma jets (APPJs) are studied using a microsecond pulse length generator producing repetitive output pulses with different polarities. The experimental results show that the APPJs excited by the pulses with positive polarity have longer plume, faster propagation speed, higher power, and more excited species, such as , O, He, , than that with the negatively excited APPJs. The images taken using an intensified charge-coupled device show that the APPJs excited by pulses with positive polarity are characterized by a bullet-like structure, while the APPJs excited by pulses with negative polarity are continuous. The propagation speed of the APPJs driven by a microsecond pulse length generator is about tens of km/s, which is similar to the APPJs driven by a kHz frequency sinusoidal voltage source. The analysis shows that the space charge accumulation effect plays an important role during the discharge. The transient enhanced electric field induced by the accumulated ions between the needle-like electrode and the nozzle in the APPJs excited by pulses with negative polarity enhances electron field emission from the cathode, which is illustrated by the bright line on the time-integrated images. This makes the shape of the APPJ excited using pulses with negative polarity different from the bullet-like shape of the APPJs excited by pulses with positive polarity.
Digital Doppler extraction demonstration with the advanced receiver (1990)

A digital Doppler extraction demonstration with the Advanced Receiver 2 (ARX 2) tracking Pioneer 10 and Voyager 2 is described. The measured results are compared with those of the Block 4 receiver that was operating in parallel with the ARX 2. It is shown that the ARX 2 outperforms the Block 4 receiver in terms of Allan variance of the Doppler residuals, the amount of which depends on the scenario of interest.
Rhodium(I)‐Catalyzed [5 + 2], [6 + 2], and [5 + 2 + 1] Cycloadditions: New Reactions for Organic Synthesis (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Towards Evaluating the Benefits of Inter-vehicle Coordination (2015)

While vehicle automation has the potential to significantly improve safety and traffic efficiency, the full potential will only be realised when vehicles start exploiting wireless communication to cooperate with each other and coordinate their interactions in advance. Ensuring that vehicles coordinate safely while improving efficiency is, however, a very challenging problem as it depends on (i) the characteristics of individual vehicles (vehicle physics, sensors), (ii) unreliable wireless communication, and (iii) driving behaviour at a microscopic level, and their compounded effects at scale. The presence of non-communicative, non-automated vehicles must also be considered. Designing and evaluating coordination protocols requires a scalable simulation framework that is accurate both microscopically (to assess safety) and macroscopically (to evaluate efficiency). Standard car-following models, where position and velocity are dictated by local input stimuli, produce sometimes unrealistic behaviour when laterally changing position, and lack support for additional inputs. Furthermore, conventional environments used to model traffic flow are either too fine-grained to scale or too coarse to appropriately simulate control logic. This paper introduces RoundaSim consisting of (i) a traffic simulator using a novel approach of mixed discrete-continuous modes of time, and (ii) a framework for implementing car-following models that supports lane-changing and coordination protocols, with additional inputs from advanced sensors and wireless communications. We show how our framework can be used to implement and evaluate a car-following model with lane changes and validate that the traffic flow achieved approximates that of real-world highways. This allows our platform to be used as a baseline for evaluating the safety and efficiency of coordination protocols.
Epitaxial Film Growth and Superconducting Behavior of Sodium−Cobalt Oxyhydrate, NaxCoO2·yH2O (x ∼ 0.3, y ∼ 1.3) (2006)

We have developed a unique multistep film growth technique, combining reactive solid-phase epitaxy (R-SPE) with an intercalation process, to fabricate epitaxial films of superconducting sodium-cobalt oxyhydrate, Na(0.3)CoO2.1.3H2O. An epitaxial film of Na(0.8)CoO2 grown on an alpha-Al2O3(0001) substrate by R-SPE was subjected to oxidation and hydration treatment, leading to the formation of a Na(0.3)CoO2.1.3H2O epitaxial film. The film exhibited metallic electrical resistivity with a superconducting transition at 4 K, similar to that of bulk single crystals. The present technique is suitable and probably the only method for the epitaxial growth of superconducting Na(0.3)CoO2.1.3H2O.