gebhart/patrepeval huggingface dataset:
The commissioning of all believers: Toward a more holistic model of global discipleship (2014)

In the last 150 years, “missions” has become a distinctive specialty often separated from the normal work of the normal church. This article examines that break and how it impacts the way in which the concept of “missions” is being communicated among academics and practitioners. This article will first look at two reasons for the separation: the historical break and the cognitive compartmentalization that results. After examining the damage done by this separation, a new holistic model for understanding the church’s mission will be presented along with the benefits that this model can bring to the church.
One‐Pot Catalytic Enantioselective Domino Nitro‐Michael/Michael Synthesis of Cyclopentanes with Four Stereocenters (2008)

A highly enantioselective organocatalytic one-pot synthesis of nitro-, formyl-, and ester-functionalized cyclopentanes with four stereocenters is presented. The cyclopentanes were formed as a predominant diasteroisomer and isolated in high yields with 97-99 % ee.
Centralized lighting control with luminaire-based occupancy and light sensing (2015)

We consider control of multiple luminaires with a central controller and occupancy and light sensors co-located at the luminaires. The sensors periodically provide local occupancy state and illumination information to the central controller. Using this sensor feedback, the central controller determines the dimming levels of the luminaires so as to adapt artificial light output to changing daylight levels and occupancy conditions, in an energy efficient way. We propose a multivariable feedback controller based on optimizing a cost function with a component corresponding to power consumption and another corresponding to illumination errors at the light sensors. The constraints are that the attained illumination value at the light sensors be no smaller than the reference set-points and that the dimming levels of luminaires are within physical limits. We compare the performance of the proposed controller with a simple stand-alone reference controller. We show via simulations in an open-plan office lighting system that the proposed controller has better performance in terms of achieving the reference set-points.
Nanoscopic X-ray tomography for correlative microscopy of a small meiofaunal sea-cucumber (2020)

In the field of correlative microscopy, light and electron microscopy form a powerful combination for morphological analyses in zoology. Due to sample thickness limitations, these imaging techniques often require sectioning to investigate small animals and thereby suffer from various artefacts. A recently introduced nanoscopic X-ray computed tomography (NanoCT) setup has been used to image several biological objects, none that were, however, embedded into resin, which is prerequisite for a multitude of correlative applications. In this study, we assess the value of this NanoCT for correlative microscopy. For this purpose, we imaged a resin-embedded, meiofaunal sea cucumber with an approximate length of 1 mm, where microCT would yield only little information about the internal anatomy. The resulting NanoCT data exhibits isotropic 3D resolution, offers deeper insights into the 3D microstructure, and thereby allows for a complete morphological characterization. For comparative purposes, the specimen was sectioned subsequently to evaluate the NanoCT data versus serial sectioning light microscopy (ss-LM). To correct for mechanical instabilities and drift artefacts, we applied an alternative alignment procedure for CT reconstruction. We thereby achieve a level of detail on the subcellular scale comparable to ss-LM images in the sectioning plane.
Improvement of NRZ signal transmission through phase modulation (2002)

Dispersion maps are required for successful nonreturn to zero (NRZ) transmission, as they allow signals to avoid the deleterious effects of four-wave mixing while still experiencing an average dispersion that is nearly zero. In wavelength-division multiplexed (WDM) systems, only one channel can be perfectly compensated in a short dispersion map; the others are compensated at the end of the transmission and thus experience a long effective dispersion map. Therefore, finding ways to minimize the distortion is of critical importance. Here, we will show that phase modulation greatly diminishes the signal distortion at high powers and with long maps, which in turn can be used by the system designers to improve the system performance by operating with higher powers.
Verifying thermal/thermo-mechanical behavior of a 3D stack - challenges and solutions (2010)

The paper describes the design challenges for a low-cost 3D Cu-TSV technology. Based on experimental characterization, we'll indicate the importance of thermal and thermo-mechanical challenges. To avoid related yield loss and/or reliability issues, thermo-mechanical and thermal hotspots should be re-solved in early phases of the design flow. We will present a possible design flow hereto based on the concept of “smart mechanical samples”.
In SilicoGenome‐Scale Metabolic Models: The Constraint‐Based Approach and Its Applications (2009)

This chapter contains sections titled: Introduction to Modeling Using the Constraint-Based Approach Building a Constraint-Based Model Computational Challenges Future Directions for Constraint-Based Modeling Conclusions References
Measurement of OH radical in nonthermal plasma for NO/NO/sub 2/ reduction (2003)

NO in exhaust gas is the major source of air pollutants, causing photochemical smog and acid rain. The corona discharge plasma process for removal of NO has been studied intensively for increasing its removal efficiency. Therefore, the development of diagnostic tools measuring major species and minor radicals produced in the plasma is important to characterize the removal process. OH is one of the oxidizing radicals that can initiate the NO removal process. The end product (HNO/sub 3/) of the NO oxidation process is produced by the OH and NO/sub 2/ reaction. Therefore the OH concentration is closely related to the removal efficiency of NO and NO/sub 2/. In the study we measure the oxidizing radical OH emission spectrum in a nonthermal plasma reactor and investigated H/sub 2/O, H/sub 2/O/sub 2/ and C/sub 2/H/sub 4/ additive effects on NO/NO/sub 2/ reduction and OH emission intensity. For the measurement of the low intensity of OH emission in a corona discharge, we made a cylinder-wire type plasma reactor that concentrated the corona emission in the center of the reactor.
Double Helix (2016)

In the past, aggregation and self-assembly have been associated principally with micellar and colloidal systems of molecules; however, with the advent of supramolecular chemistry, molecular self-assembly has been opened to a much wider understanding that has facilitated access to a variety of different shapes and sizes, along with the construction of new and fascinating molecular topologies. This document aims at defining more than 150 terms related to aggregation and self-assembly in the particular case of macromolecules. The list is restricted to the most commonly encountered terms.
Revertants of a Chinese hamster ovary cell mutant resistant to suppression by an analog of cholesterol: isolation and partial biochemical characterization (1982)

A highly efficient selection procedure was developed for isolating revertants of Chinese hamster ovary (CHO) cell mutants resistant to suppression by 25-hydroxy-cholesterol. The procedure is based on the fact that the specific polyene antibiotic amphotericin B caused a lethal porous complex formation with membrane cholesterol only in cholesterol-rich cells. The wild-type cells and the revertant cells switched to grow from fetal calf serum medium to delipidated fetal calf serum medium for approximately 1 day became deficient in cellular cholesterol content. These cells, unlike the cholesterol-rich mutant cells, became much less sensitive to amphotericin B cytotoxicity. The spontaneous reversion frequency of a previously reported 25-hydroxycholesterol-resistant cell clone, 25-RA [Chang, T.-Y., & Limanek, J.S. (1980) J. Biol. Chem. 255, 7787-7795], was found to be approximately 3 X 10(-6), a frequency comparable to other single gene mutations of CHO cells. Biochemical analyses of three of these revertants showed that all defects manifested in 25-RA cells reverted back in parallel, a result suggesting that these observed defects in 25-RA cells are due to a single mutation event, thus supporting the hypothesis (Chang & Limanek, 1980) that a common controlling factor may be involved in mediating the suppressive action(s) of the cholesterol analogue on various cholesterogenic enzyme activities. The function of this common controlling factor is rendered abnormal in 25-RA cells by mutation.
Toward modeling of radio-frequency ablation lesions for image-guided left atrial fibrillation therapy: model formulation and preliminary evaluation. (2013)

In the context of image-guided left atrial fibrillation therapy, relatively very little work has been done to consider the changes that occur in the tissue during ablation in order to monitor therapy delivery. Here we describe a technique to predict the lesion progression and monitor the radio-frequency energy delivery via a thermal ablation model that uses heat transfer principles to estimate the tissue temperature distribution and resulting lesion. A preliminary evaluation of the model was conducted in ex vivo skeletal beef muscle tissue while emulating a clinically relevant tissue ablation protocol. The predicted temperature distribution within the tissue was assessed against that measured directly using fiberoptic temperature probes and showed agreement within 5°C between the model-predicted and experimentally measured tissue temperatures at prescribed locations. We believe this technique is capable of providing reasonably accurate representations of the tissue response to radio-frequency energy delivery.
Conducting PEDOT Nanoparticles: Controlling Colloidal Stability and Electrical Properties (2018)

The synthesis of conducting polymer nanoparticles by oxidative polymerization can be a challenge because the addition of oxidizers may compromise the colloidal stability of the system. In this work, we report the successful synthesis of poly(3,4-ethylenedioxythiophene) (PEDOT) nanoparticles by means of miniemulsion polymerization. We study the role of oxidizing agents (iron(III) p-toluenesulfonate and hydrogen peroxide) during the particle formation and in the electric properties. The presence of hydrogen peroxide is demonstrated to be crucial in the macroscopic stability of the suspensions and in the morphology of the resulting nanoparticles. The obtained suspensions, containing particles of diameters of around 30 nm, are stable for several months. The electrical conductivity increases with increasing the content of iron(III) p-toluenesulfonate, but it decreases with addition of hydrogen peroxide, which can be explained by secondary reactions in the polymerization process.
Numerical Study on Steady- State Cracking of Composites (2007)

Peer Reviewed
Topological Interference Management Framework for Device-to-Device Communication (2018)

This letter considers the topological interference management (TIM) problem in a partially connected network where Device-to-Device (D2D) enabled devices are not aware of the surrounding devices' channel state information but only of the network connectivity to cancel the interference occurred. We model TIM as a low-rank-matrix-completion problem and solve it using a novel scheme based on semidefinite programming while overcoming TIM matrix special structure with hard constraints. Our simulations show a matrix rank reduction ability that outperforms other existing methods, and thus corresponds to a lessening in signal interference: a key need in D2D networks.
Crystal structures of monensin B lithium and silver salts (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrystal structures of monensin B lithium and silver saltsDavid M. Walba, Mark Hermsmeier, R. Curtis Haltiwanger, and Jan H. NoordikCite this: J. Org. Chem. 1986, 51, 2, 245–247Publication Date (Print):January 1, 1986Publication History Published online1 May 2002Published inissue 1 January 1986https://pubs.acs.org/doi/10.1021/jo00352a023https://doi.org/10.1021/jo00352a023research-articleACS PublicationsRequest reuse permissionsArticle Views81Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Estimating cloth simulation parameters from video (2003)

Cloth simulations are notoriously difficult to tune due to the many parameters that must be adjusted to achieve the look of a particular fabric. In this paper, we present an algorithm for estimating the parameters of a cloth simulation from video data of real fabric. A perceptually motivated metric based on matching between folds is used to compare video of real cloth with simulation. This metric compares two video sequences of cloth and returns a number that measures the differences in their folds. Simulated annealing is used to minimize the frame by frame error between the metric for a given simulation and the real-world footage. To estimate all the cloth parameters, we identify simple static and dynamic calibration experiments that use small swatches of the fabric. To demonstrate the power of this approach, we use our algorithm to find the parameters for four different fabrics. We show the match between the video footage and simulated motion on the calibration experiments, on new video sequences for the swatches, and on a simulation of a full skirt.
Quantitative probe of the dynamics of mass transfer of water in organic porous materials by means of neutron spectroscopy: The case of covalent triazine-based frameworks (2020)

We study the mass transfer and interaction of water through/with two porous covalent triazine-based frameworks (CTFs), by neutron spectroscopy. Inelastic neutron scattering evidences an interaction between CTF-CN and water, not observed for CTF-2, and that is correlated with the large amount of bound water or very slow diffusing water observed for CTF-CN, using quasi-elastic neutron scattering (QENS). The water dynamics is also impacted by CTF-2 but to a lesser extent. The translational diffusion of constrained water in CTF-2 is well quantified by fitting the QENS spectra.
Peer architectures for knowledge sharing (2005)

Large-scale sharing of biologic information requires developing new approaches for accessing large numbers of data sources. For example, consider an experiment that measures genome-wide expression levels. Analyzing these results requires annotating them with information culled from public repositories, which are stored in separate databases, maintained by various organizations, using dissimilar nomenclature. Given the cost of manually visiting each data source, an automated solution is required. 
One solution to this problem is data integration, in which the user is provided a logical view of the underlying sources. These systems provide syntactic and semantic mediation, but generating the mediated view requires consensus concerning the intended semantics. In biomedical research it is neither feasible nor desirable to establish wide-scale consensus. Thus, a new framework for information is required in which each participant can make its own semantic decisions. 
This dissertation demonstrates that data integration technology can be extended to meet the challenges of integrating biologic information. These extensions support knowledge sharing in a peer-based environment. Each participant gains the benefits of data integration without the burden of establishing consensus a priori. 
We begin by establishing a framework for peer-based integration in which software components can easily be extended. We validate this framework by implementing multiple systems within the framework. We then describe a novel query language that allows a query to constrain results based on data and metadata. This language blurs the traditional distinction between instances and schemata and serves as the public interface to a number of online genetic databases. 
In a peer-based system, schemata are coordinated using semantic mappings. Given a query posed against one schema, we provide a reformulation algorithm that generates equivalent rewritings based on mappings expressed as logical definitions. We experimentally validate that these mappings are more expressive than traditional declarative mappings using queries. Finally, we describe a set of rules for propagating changes to the underlying data, which are used to identify efficient strategies for maintaining data replicas. 
These contributions demonstrate that data integration technology can be extended to support peer-based knowledge integration, with which we are better able to meet the particular needs of biologic researchers.
Towards Memory-Efficient Neural Networks via Multi-Level in situ Generation (2021)

Deep neural networks (DNN) have shown superior performance in a variety of tasks. As they rapidly evolve, their escalating computation and memory demands make it challenging to deploy them on resource-constrained edge devices. Though extensive efficient accelerator designs, from traditional electronics to emerging photonics, have been successfully demonstrated, they are still bottlenecked by expensive memory accesses due to tremendous gaps between the bandwidth/power/latency of electrical memory and computing cores. Previous solutions fail to fully-leverage the ultra-fast computational speed of emerging DNN accelerators to break through the critical memory bound. In this work, we propose a general and unified framework to trade expensive memory transactions with ultra-fast on-chip computations, directly translating to performance improvement. We are the first to jointly explore the intrinsic correlations and bit-level redundancy within DNN kernels and propose a multi-level in situ generation mechanism with mixed-precision bases to achieve on-the-fly recovery of high-resolution parameters with minimum hardware overhead. Extensive experiments demonstrate that our proposed joint method can boost the memory efficiency by 10-20x with comparable accuracy over four state-of-the-art designs, when benchmarked on ResNet-18/DenseNet-121/MobileNetV2/V3 with various tasks.
Getting it right the first time: predicted performance guarantees from the analysis of emergent behavior in autonomous and semi-autonomous systems (2012)

A crucially important aspect for mission-critical robotic operations is ensuring as best as possible that an autonomous system be able to complete its task. In a project for the Defense Threat Reduction Agency (DTRA) we are developing methods to provide such guidance, specifically for counter-Weapons of Mass Destruction (C-WMD) missions. In this paper, we describe the scenarios under consideration, the performance measures and metrics being developed, and an outline of the mechanisms for providing performance guarantees.
Effects of Recruitment Maneuver on Atelectasis in Anesthetized Children (2003)

Frequency of atelectasis was much less following the alveolar recruitment strategy, compared with children who did not have the maneuver performed. The mere application of 5 cm H2O of CPAP without a prior recruitment did not show the same treatment effect and showed no difference compared to the control group without PEEP.
HCV and flaviviruses hijack cellular mechanisms for nuclear STAT2 degradation: Up-regulation of PDLIM2 suppresses the innate immune response (2019)

Host encounters with viruses lead to an innate immune response that must be rapid and broadly targeted but also tightly regulated to avoid the detrimental effects of unregulated interferon expression. Viral stimulation of host negative regulatory mechanisms is an alternate method of suppressing the host innate immune response. We examined three key mediators of the innate immune response: NF-KB, STAT1 and STAT2 during HCV infection in order to investigate the paradoxical induction of an innate immune response by HCV despite a multitude of mechanisms combating the host response. During infection, we find that all three are repressed only in HCV infected cells but not in uninfected bystander cells, both in vivo in chimeric mouse livers and in cultured Huh7.5 cells after IFNα treatment. We show here that HCV and Flaviviruses suppress the innate immune response by upregulation of PDLIM2, independent of the host interferon response. We show PDLIM2 is an E3 ubiquitin ligase that also acts to stimulate nuclear degradation of STAT2. Interferon dependent relocalization of STAT1/2 to the nucleus leads to PDLIM2 ubiquitination of STAT2 but not STAT1 and the proteasome-dependent degradation of STAT2, predominantly within the nucleus. CRISPR/Cas9 knockout of PDLIM2 results in increased levels of STAT2 following IFNα treatment, retention of STAT2 within the nucleus of HCV infected cells after IFNα stimulation, increased interferon response, and increased resistance to infection by several flaviviruses, indicating that PDLIM2 is a global regulator of the interferon response.
Measuring the Impact of Food Immunotherapy on Health-Related Quality of Life in Clinical Trials (2022)

Food allergy is a common, and often lifelong, disorder with considerable negative impact on the quality of life of those affected and their families. While several promising immunotherapies for food allergy have either been approved or are in late-phase clinical trials based on demonstrated effectiveness at inducing desensitization, evidence of benefit in terms of improving patient-centered outcomes is inconsistent. Historically, health-related quality of life has not been prioritized as an endpoint in food immunotherapy trials and, even when included, findings have been undermined by methodological limitations of the measurement instruments used and issues with data interpretation. This review highlights the importance of measuring health-related quality of life as an endpoint in food immunotherapy trials and discusses the strengths and limitations of available evidence in this regard, with a focus on the appropriate use of assessment instruments and interpretation of findings. There remains much to learn regarding the impact of food immunotherapies on patient wellbeing, both during treatment and over the longer term. Our aim is to assist clinicians, researchers, policy makers and consumers in their interpretation of the existing literature, and to promote greater scientific rigor in the design and selection of outcome measurement frameworks for future studies evaluating the efficacy of immunotherapy treatments for food allergy.