gebhart/patrepeval huggingface dataset:
Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition (2020)

A hallmark of metastasis is the adaptation of tumor cells to new environments. Metabolic constraints imposed by the serine and glycine-limited brain environment restrict metastatic tumor growth. How brain metastases overcome these growth-prohibitive conditions is poorly understood. Here, we demonstrate that 3-phosphoglycerate dehydrogenase (PHGDH), which catalyzes the rate-limiting step of glucose-derived serine synthesis, is a major determinant of brain metastasis in multiple human cancer types and preclinical models. Enhanced serine synthesis proved important for nucleotide production and cell proliferation in highly aggressive brain metastatic cells. <i>In vivo</i>, genetic suppression and pharmacologic inhibition of PHGDH attenuated brain metastasis, but not extracranial tumor growth, and improved overall survival in mice. These results reveal that extracellular amino acid availability determines serine synthesis pathway dependence, and suggest that PHGDH inhibitors may be useful in the treatment of brain metastasis. SIGNIFICANCE: Using proteomics, metabolomics, and multiple brain metastasis models, we demonstrate that the nutrient-limited environment of the brain potentiates brain metastasis susceptibility to serine synthesis inhibition. These findings underscore the importance of studying cancer metabolism in physiologically relevant contexts, and provide a rationale for using PHGDH inhibitors to treat brain metastasis.<i>This article is highlighted in the In This Issue feature, p. 1241</i>.
A general synthetic route to isobenzofurans bearing a functionalized C-1 substituent (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA general synthetic route to isobenzofurans bearing a functionalized C-1 substituentSanath K. Meegalla and Russell RodrigoCite this: J. Org. Chem. 1991, 56, 5, 1882–1888Publication Date (Print):March 1, 1991Publication History Published online1 May 2002Published inissue 1 March 1991https://pubs.acs.org/doi/10.1021/jo00005a040https://doi.org/10.1021/jo00005a040research-articleACS PublicationsRequest reuse permissionsArticle Views467Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplemental Movie 2 from AXL Inhibition Sensitizes Mesenchymal Cancer Cells to Antimitotic Drugs (2023)

&lt;p&gt;Timelapse movie of HeLa cells treated with R428 (1ÃŽÂ¼M).&lt;/p&gt;
Lipid Peroxidation Induced by Shockwave Lithotripsy (1998)

To determine the relation between high-energy shockwaves (HESW) and the presence of lipid peroxidation produces, juvenile pigs were subjected to shockwave lithotripsy (SWL). After lithotripsy, both treated and control kidneys were analyzed, along with urine samples collected before, during, and after SWL. Thiobarbituric acid-reactive substance (TBARS) and lipid-conjugated diene (CD) concentrations, used as markers for membrane lipid peroxidation, were determined in the kidney and urine samples. Significantly increased mean TBARS concentrations (146%) were associated with homogenates of lithotripsy-treated kidneys, 77.8 +/- 14.4 (SD) mmol/g v the controls, 31.4 +/- 14.9 mmol/g. Lithotripsy induction of lipid peroxidation products in the cortex, the gross damage site, and the respective medulla were also examined. In HESW-treated cortex samples, increased TBARS concentrations were seen--75.0 +/- 21.3 mmol/g--compared with untreated controls-- 45.2+/- 5.6 mmol/g--while increased CD concentrations (168%) were observed in the medulla of HESW-treated samples. No significant differences were observed in TBARS or CD concentrations in urine samples from control or treated kidneys, yet specific lipid hydroperperoxides were detected in the urine of HESW-treated kidneys. We conclude that HESW lithotripsy of swine kidneys is associated with increased lipid peroxidation products that may cause further cellular damage. Lipid peroxidation induced by SWL may be one of several mechanisms that lead to other potential bioeffects. Finally, analysis of specific lipid hydroperoxides in the urine of HESW-treated kidneys may serve as a noninvasive marker of renal injury after clinical SWL.
Impatient Bandits: Optimizing Recommendations for the Long-Term Without Delay (2023)

Recommender systems are a ubiquitous feature of online platforms. Increasingly, they are explicitly tasked with increasing users' long-term satisfaction. In this context, we study a content exploration task, which we formalize as a multi-armed bandit problem with delayed rewards. We observe that there is an apparent trade-off in choosing the learning signal: Waiting for the full reward to become available might take several weeks, hurting the rate at which learning happens, whereas measuring short-term proxy rewards reflects the actual long-term goal only imperfectly. We address this challenge in two steps. First, we develop a predictive model of delayed rewards that incorporates all information obtained to date. Full observations as well as partial (short or medium-term) outcomes are combined through a Bayesian filter to obtain a probabilistic belief. Second, we devise a bandit algorithm that takes advantage of this new predictive model. The algorithm quickly learns to identify content aligned with long-term success by carefully balancing exploration and exploitation. We apply our approach to a podcast recommendation problem, where we seek to identify shows that users engage with repeatedly over two months. We empirically validate that our approach results in substantially better performance compared to approaches that either optimize for short-term proxies, or wait for the long-term outcome to be fully realized.
Measurement of a 1.3 m Reflectarray in flat panels in Ku band (2012)

International audience
Conducta frente a la sospecha de infección relacionada a catéter venoso central para hemodiálisis (2006)

Introducción: el poder definir en forma precisa en qué pacientes portadores de un catéter venoso central (CVC) para hemodiálisis con sospecha de infección relacionada a catéter (IRcat) se confirma efectivamente la IRcat, es de vital importancia para evitar el retiro innecesario del mismo en pacientes en quienes frecuentemente existe dificultad para lograr un acceso venoso central. Objetivos: 1) establecer la frecuencia de CVC retirados por sospecha de una IRcat finalmente no confirmada, 2) identificar factores clínicos que nos ayuden a mejorar la precisión diagnóstica de una IRcat. Material y método: Tipo de estudio: observacional, prospectivo. Período de estudio: se realizó durante cinco meses (1º de mayo al 30 de setiembre de 2003) en el Servicio de Nefrología del Hospital de Clínicas. Criterio de inclusión: pacientes mayores de 18 años asistidos en el Departamento de Nefrología, a los cuales se les colocó un CVC para hemodiálisis. Resultados: se enrolaron en forma sucesiva 107 CVC, 50 (46,7%) se retiraron por causa infecciosa y 57 (53,3%) por otra causa diferente a la infecciosa. Los 50 catéteres retirados por sospecha de IRcat fueron divididos en dos grupos: A) CVC retirados por sospecha de infección y que finalmente tuvieron una IRcat, n = 22 (44%), y grupo B) CVC retirados por sospecha de infección y que finalmente no tuvieron una IRcat, n = 28 (56%). Se realizó una comparación de 20 variables a través de un análisis univariado. El tener un CVC insertado por más de 14 días se asoció con que la fiebre se corresponda con una IRcat (p = 0,02, OR = 2,1, IC 95% = 1,2-3,7). Conclusiones: en 56% de los CVC para hemodiálisis retiradas por sospecha de IRcat no se confirmó la infección. El tener insertado un CVC por más de 14 días se relaciona con que la actividad infecciosa se corresponda con una IRcat.
Using Artificial Neural Network Models for Eutrophication Prediction (2013)

Artificial neural network (ANN), a data driven modeling approach, is proposed to predict the water quality indicators of Lake Fuxian, the deepest lake of southwest China. To determine the non-linear relationships between the water quality factors and the eutrophication indicators, several ANN models was chosen for the investigation. A commonly used back-propagation neural network model was used to relate the key factors that influence a number of water quality indicators such as dissolved oxygen (DO), total phosphorus (TP), chlorophyll-a (Chl-a), and secchi disk depth (SD) in Lake Fuxian. The measured data were fed to the input layer, representing forcing functions to control the in- lake bio-chemical processes. Eutrophication indicators such as DO, TN, Chl-a and SD were represented in the output layers. The results indicated that the back-propagation neural network model performs good in ten months prediction and the neural network is able to predict these indicators with reasonable accuracy. This study also suggested that the neural network is a valuable tool for lake management.
New physical model for ultra-scaled 3D nitride-trapping non-volatile memories (2008)

In this paper, we present a semi-analytical model tailored for nitride Charge-Trap TriGate (CT-3G) non-volatile memories under uniform stress: Fowler-Nordheim (FN) program (P) and erase (E) performances are reproduced. This model presents innovations in the tunnelling current calculation at corners through the Hankel function formalism. The validation of the model is operated through extensive comparisons with experimental data obtained on ultra-scaled devices with different aspect ratios and gate stacks. Scaling opportunities of such kind of 3D devices are deeply discussed.
Home server for home digital service environments (2003)

This paper proposes a new scheme of the home server platform for providing home digital services by connecting home networks and the Internet. The proposed scheme is an integrated form of a home multimedia server, a home control server, and a home information server. The proposed system has an interface between access networks and home networks, various kinds of wired and wireless home networks devices, and multimedia processing modules. As examples of home digital services, the system provides a digital TV service, a remote multimedia service, and an instant message service based on the open service gateway initiative (OSGi) framework. We have implemented the proposed home server scheme, and verify that the system can be a core device of the home digital service environments.
ChemInform Abstract: Synthesis of Cytotoxic Ferrocenyl Flavones via a Ferricenium‐Mediated 1,6‐Oxidative Cyclization. (2010)

Abstract The oxidation of the ferrocenyl group of 2′‐hydroxyferrocenyl chalcones (II) activates the β‐position of the unsaturated ketone to nucleophilic attack to yield the first examples of ferrocenyl flavones (III).
[The geroprotective effect of the amino acids and tripeptides in the cartilage tissue culture in rats]. (2011)

The effect of 20 coded amino acids and synthetic bioregulatory tripeptides, in the effective concentration 0.05 ng/ml, was investigated in organotypic tissue culture on the cell proliferation development in the cartilage tissue explants in young 3 and old 24 months old rats. The number of the amino acid stimulated proliferation was decreased in the tissue culture from the old rats in 6 times, as compared to the young rats. The tripeptides demonstrated the stimulated proliferation effect in the tissue culture both from the young and old animals, what is a base for the further study as the geroprotective preparations.
Longitudinal beam dynamics studies at the PIP-II injector test facility (2019)

The Proton Improvement Plan, Stage Two (PIP-II), is a program of upgrades proposed for the Fermilab injection complex, the central part of which is an 800 MeV, 2 mA CW-compatible SRF linac. A prototype of the PIP-II linac front-end called the PIP-II Injector Test (PIP2IT) is being built at Fermilab. As of now, a 15 mA DC, 30 keV H[Formula: see text] ion source, a 2 m long Low Energy Beam Transport (LEBT), a 2.1 MeV CW Radio-Frequency Quadrupole (RFQ), followed by a 10 m Medium Energy Beam Transport (MEBT) have been installed and tested. A Fast Faraday Cup (FFC) installed in the MEBT measures the length of a beamlet cut out of the bunch by a small-size entrance hole of the FFC. The information about the bunch length measured at various settings allows for the reconstruction of the longitudinal beam dynamics and optimization of injection into the first cryomodule.
Validation of Dual-Doppler Wind Profiles with in situ Anemometry (2015)

Abstract Typical methods used to acquire wind profiles from Doppler radar measurements rely on plan position indicator (PPI) scans being performed at multiple elevation angles to utilize the velocity–azimuth display technique or to construct dual-Doppler synthesis. These techniques, as well as those employed by wind profilers, often produce wind profiles that lack the spatial or temporal resolution to resolve finescale features. If two radars perform range–height indicator (RHI) scans (constant azimuth, multiple elevations) along azimuths separated by approximately 90 ° , then the intersection of the coordinated RHI planes represents a vertical set of points where dual-Doppler wind syntheses are possible and wind speed and direction profiles can be retrieved. This method also allows for the generation of high-resolution wind time histories that can be compared to anemometer time histories. This study focuses on the use of the coordinated RHI scanning strategy by two high-resolution mobile Doppler radars in close proximity to a 200-m instrumented tower. In one of the first high-resolution, long-duration comparisons of dual-Doppler wind synthesis with in situ anemometry, the mean and turbulence states of the wind measured by each platform were compared in varying atmospheric conditions. Examination of mean wind speed and direction profiles in both clear-air (nonprecipitating) and precipitating environments revealed excellent agreement above approximately 50 m. Below this level, dual-Doppler wind speeds were still good but slightly overestimated as compared to the anemometer-measured wind speeds in heavy precipitation. Bulk turbulence parameters were also slightly underestimated by the dual-Doppler syntheses.
Mechanistic Study on Reversible Change of Light Scattering Properties of the Polymer Films Involving Dispersed Microspheres of Fatty Acids. (1995)

高分子中に脂肪酸結晶粒子が分散された複合膜の熱可逆的な光散乱性変化について,X線回折を用い脂肪酸の結晶化過程を追究した結二果,次のような現象が観測された.(a)脂肪酸の結晶化温度Tcは,降温開始時の溶融の程度に強く依存して変化した.完全に溶融する温度から降温すると,箕は融点より約30℃ 低下した.また,溶融途中の温度から降温すると,Tcはこれより高くなり,溶融初期からの降温では融点の直下で結晶化した.(b)複合膜の光散乱性は,脂肪酸のTcと高分子のガラス転移温度Tgの関係によって強い影響を受け,TcがTgより低下すると白濁した.(a)(b)の観測結果の解析から,以下の結論を得た・光を散乱した白濁状態は,融点以上からの降温で,Tg以下の高分子が硬くなった状態で脂肪酸が結晶化することにより,高分子が脂肪酸の体積収縮に追従できなくなり,粒子中に空隙が形成された状態である.透明化は,昇温過程の高分子の軟化と結晶表面の溶融で,空隙が消失することにより起こり,その状態は降温過程の織以上の温度で結晶化し固定される.空隙の形成と消失は,光散乱性の変化と対応した膜厚の変化,および超音波顕微鏡によって裏付けられた.
Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics study (2022)

Support for the study was provided from National Institute of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID) (U01 AI150741-01S1 and T32-AI052073), the Stanford's Innovative Medicines Accelerator, National Institutes of Health/National Institute on Drug Abuse (NIH/NIDA) DP1DA046089, and anonymous donors to Stanford University. Peginterferon lambda provided by Eiger BioPharmaceuticals.
Table S1A-D from Kub5-Hera<i><sup>RPRD1B</sup></i> Deficiency Promotes “BRCAness” and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers (2023)

&lt;p&gt;Loss of K-H genetic alterations&lt;/p&gt;
Targeting intracellular bacteria with an extended cationic amphiphilic polyproline helix (2015)

An extended cationic and amphiphilic polyproline helix (CAPH) is described with a dual mode of action: effective cell penetration of human macrophages, and potent antimicrobial activity in vitro against both Gram-positive and negative pathogens, including Acinetobacter baumannii, Escherichia coli O157 and Bacillus anthracis. This dual action was successfully combined to clear pathogenic bacteria (Brucella and Salmonella) residing within macrophages.
Multi-user diversity for the multiple antenna broadcast channel with linear receivers: asymptotic analysis (2005)

Opportunistic scheduling based on channel state information at the transmitter can provide significant performance gains for transmission over broadcast channels by exploiting the independence of fading realizations across the user population. For a multiple antenna broadcast channel this opportunism (commonly termed multiuser diversity) takes the form of selecting either a single "best" user (opportunistic time-sharing) or a collection of users whose channels jointly maximize the sum of allocated rates during every transmission (multiuser multiplexing). In this paper, we analytically characterize the capacity gain achieved by opportunistic schedulers with both single-user and multiuser multiplexing. We characterize capacity gain with both optimal receivers and the more practical linear receivers. We investigate the effect of multiuser diversity on the performance of linear receivers. Asymptotically in size of the user population, we prove that (i) capacity with the suboptimal linear receiver scales identically compared with optimal signaling, (ii) capacity with multiuser linear receivers scales identically compared with the capacity of the multiple antenna broadcast channel achieved by "dirty-paper" coding. Both these capacity scaling laws in (i) and (ii) exhibit a log log N dependence on size of the user population, N.
Physiological modulation of renal function by the renal dopaminergic system (1990)

1. The renal dopaminergic system is a potentially important regulator of sodium homeostasis and kidney function. 2. We have presented evidence that dopamine acts as a paracrine substance at DA-1 and DA-2 receptors in the physiological control of renal function. 3. Much more information is required regarding basic cellular mechanisms and the functional regulation of the system so that the role of renal dopamine can be placed clearly in context with other established hormonal regulatory systems.
Robust Antitumor Immunity in a Patient with Metastatic Colorectal Cancer Treated with Cytotoxic Regimens (2021)

Microsatellite-stable (MSS) colorectal cancers are characterized by low mutation burden and limited immune-cell infiltration and thereby respond poorly to immunotherapy. Here, we report a case of metastatic MSS colorectal cancer with a robust anticancer immune response. The primary tumor was resected in 2012, and the patient received several cycles of chemotherapy until 2017. In 2018, the patient underwent a left hepatectomy to remove a new metastasis. Analysis of the metastatic tumor revealed a strong CD8<sup>+</sup> T-cell response. A high frequency of CD8<sup>+</sup> T cells coexpressed CD39 and CD103, a phenotype characteristic of tumor-reactive cells. Using whole-exome sequencing, we identified somatic mutations that generated peptides recognized by CD39<sup>+</sup>CD103<sup>+</sup>CD8<sup>+</sup> T cells. The observed reactivity against the tumor was dominated by the response to a single mutation that emerged in the metastasis. Somatic mutations that were not immunogenic in the primary tumor led to robust CD8<sup>+</sup> T-cell expansion later during disease progression. Our data suggest that the cytotoxic treatment regimen received by the patient might be responsible for this effect. Hence, the capacity of cytotoxic regimens to prime the immune system in colorectal cancer patients should be investigated further and might provide a rationale for combination with immunotherapy.
INFRARED SPECTRA AND STRUCTURES OF MATRIX ISOLATED HSiOH AND HSiF (1982)

The hydroxysilylene, HSiOH, and the fluorosilylene, HSiF, have been isolated in solid argon. Frequencies for all the infrared active modes of the two molecules have been accurately measured. Band assignments for trans- HSiOH, trans- and cis- HSiOD and DSiOD have been made. The SiOH bond angle has been calculated for a planar structure of $C_{s}$ symmetry using the Redlich-Teller product rule and the torsional frequencies for HSiOH, HSiOD and DSiOD. Normal coordinate analyses have been carried out using the measured frequencies for six isotopomers of hydroxysilylene, namely, HSiOH, HSiOD, DSiOD, $HSi^{18}OH, HSi^{18}OD$ and $DSi^{18}OD$, and for two isotopomers of fluorosilylene, HSiF and DSiF. It was shown that it is possible to transfer the force constants of HSiF to the large molecule HSiOH.
Cyclopentanones from nucleophilic addition/carbonylation to (.eta.4-diene)Fe(CO)3 complexes (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclopentanones from nucleophilic addition/carbonylation to (.eta.4-diene)Fe(CO)3 complexesM. F. Semmelhack, James W. Herndon, and John K. LiuCite this: Organometallics 1983, 2, 12, 1885–1888Publication Date (Print):December 1, 1983Publication History Published online1 May 2002Published inissue 1 December 1983https://pubs.acs.org/doi/10.1021/om50006a035https://doi.org/10.1021/om50006a035research-articleACS PublicationsRequest reuse permissionsArticle Views140Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts