gebhart/patrepeval huggingface dataset:
A properties comparison between copper and graphene-based UWB MIMO planar antennas (2016)

This paper presents the comparison of two Ultrawideband (UWB) Multiple-Input-Multiple-Output (MIMO) antennas with different conductors. In the simulation two UWB-MIMO antennas with copper conductors and graphene-based conductors (GBC) are designed separately. The ground planes of both radiators are made of copper, only the top side is made with different conductors. A T-shaped decoupling structure is placed on the ground plane to reduce the coupling between the radiating patches. These two prototypes, one with copper conductors and the other one with GBCs are fabricated. A good agreement between the S-parameters of both prototypes is found. The measured radiation patterns of both prototypes also exhibit similar properties. Whereas, the GBC antenna showed a lower gain as compared to the copper antenna, as depicted in radiation patterns. However, impedance matching and the radiation characteristics of the GBC antenna also showed that graphene can be a good alternative to copper in UWB-MIMO conformal antennas.
Reversing the Action of Noncompetitive Inhibitors (MK-801 and Cocaine) on a Protein (Nicotinic Acetylcholine Receptor)-Mediated Reaction (2003)

The nicotinic acetylcholine receptor (nAChR) is one of five structurally related membrane proteins required for communication between approximately 10(12) cells of the mammalian nervous system. The receptor is inhibited by both therapeutic agents and abused drugs. Understanding the mechanism of noncompetitive allosteric inhibitors of the nicotinic acetylcholine receptor is a long-standing and intensely investigated problem. During the past two decades, many attempts have been made to find drugs that prevent cocaine inhibition, including the synthesis of hundreds of cocaine analogues and derivatives, so far without success. The use of newly developed transient kinetic techniques in investigations of the inhibition of the receptor by the anticonvulsant MK-801 [(+)-dizocilpine] and the abused drug cocaine led to an inhibition mechanism not previously proposed. This mechanism indicates the properties of compounds that would prevent allosteric inhibition of the receptor and how to test for such compounds. Here we present the first evidence that small organic compounds (cocaine derivatives) exist that prevent cocaine and MK-801 inhibition of this receptor. These compounds are RTI-4229-70, a previously synthesized cocaine derivative, and based on its structure four newly synthesized cocaine derivatives, RCS-III-143, RCS-III-140A, RCS-III-218, and RCS-III-202A. Because the nAChR desensitizes rapidly, to make the required measurements a cell-flow technique with a time resolution of 10 ms was used to equilibrate BCH(3) cells containing the fetal mouse muscle-type nAChR with carbamoylcholine. The resulting whole-cell current pertaining to the nondesensitized nAChR was determined. Inhibitors and compounds that alleviate inhibition were tested by their effect on the whole-cell current.
Real-World Use and Outcomes of ALK-Positive Crizotinib-Treated Metastatic NSCLC in US Community Oncology Practices: A Retrospective Observational Study (2018)

Crizotinib usage evaluated within the real-world setting is consistent with prior phase III clinical trial data, and illustrates the real-world effectiveness of crizotinib.
Overall Quality Prediction for HTTP Adaptive Streaming Using LSTM Network (2020)

HTTP Adaptive Streaming has become a popular solution for multimedia delivery nowadays. However, due to network bandwidth fluctuations, video quality strongly varies during streaming. Therefore, a key challenge in HTTP Adaptive Streaming is how to evaluate the overall quality of a streaming session. In this article, a machine learning approach is proposed for overall quality prediction, where each segment in a streaming session is represented by a set of features. Two options of the feature set are investigated. In the first option, we use four features, namely segment quality, content characteristics, stalling duration, and padding. The second option consists of three features, namely bitstream-level parameters, stalling duration, and padding. The features are fed into a Long Short Term Memory (LSTM) network that is capable of exploring temporal relations between impairment events of quality variations and stalling events. The overall quality is predicted from the outputs of the LSTM network using a linear regression module. Through experimental results, it is shown that the proposed approach achieves a high prediction performance and outperforms seven existing approaches. Especially, the second option is found to be both efficient and effective. The source code of the proposed approach has been made available to the public.
Supplementary Figure 1 from Adoptive Cell Therapy for Lymphoma with CD4 T Cells Depleted of CD137-Expressing Regulatory T Cells (2023)

&lt;p&gt;PDF file - 139K, Reconstitution of endogenous CD8 T cells post-transplant.&lt;/p&gt;
Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4-d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family (2016)

Structure-activity relationships for inhibition of erbB1, erbB2, and erbB4 were determined for a series of quinazoline- and pyrido[3,4-d]pyrimidine-based analogues of the irreversible pan-erbB inhibitor, canertinib. Cyclic amine bearing crotonamides were determined to provide rapid inhibition of cellular erbB1 autophosphorylation and good metabolic stability in liver microsome and hepatocyte assays. The influence of 4-anilino substitution on pan-erbB inhibitory potency was investigated. Several anilines were identified as providing potent, reversible pan-erbB inhibition. Optimum 4- and 6-substituents with known 7-substituents provided preferred irreversible inhibitors for pharmacodynamic testing in vivo. Quinazoline 54 and pyrido[3,4-d]pyrimidine 71 were identified as clearly superior to canertinib. Both compounds possess a piperidinyl crotonamide Michael acceptor and a 3-chloro-4-fluoroaniline, indicating these as optimized 6- and 4-substituents, respectively. Pharmacokinetic comparison of compounds 54 and 71 across three species selected compound 54 as the preferred candidate. Compound 54 (PF-00299804) has been assigned the nomenclature of dacomitinib and is currently under clinical evaluation.
Induction of aldose reductase and xylitol dehydrogenase activities in Candida tenuis CBS 4435 (2006)

In this study the ability of various sugars and sugar alcohols to induce aldose reductase (xylose reductase) and xylitol dehydrogenase (xylulose reductase) activities in the yeast Candida tenuis was investigated. Both enzyme activities were induced when the organism was grown on D-xylose or L-arabinose as well as on the structurally related sugars D-arabinose or D-lyxose. Mixtures of D-xylose with the more rapidly metabolizable sugar D-glucose resulted in a decrease in the levels of both enzymes formed. These results show that the utilization of D-xylose by C. tenuis is regulated by induction and catabolite repression. Furthermore, the different patterns of induction on distinct sugars suggest that the synthesis of both enzymes is not under coordinate control.
Procedimiento de obtención de dodecalactama en presencia de líquidos iónicos (2007)

Referencia OEPM: P200402776.-- Fecha de solicitud: 18/11/2004.-- Titulares: Ube Corporation Europe, S.A.
Photoinduced activation of GFP-like proteins in tissues of reef corals (2006)

A variety of fluorescent and chromophoric proteins homologous to the green fluorescent protein (GFP) has been recently discovered and cloned from non-bioluminescent marine animals, such as corals, and now provide a multitude of colors for use in fluorescence imaging applications. Recently, a novel fluorescence imaging methodology has emerged that utilizes the unique photoactivatory property of several GFP-like proteins, which respond to irradiation by altering their optical properties, thereby providing a new spatio-temporal capability to the GFP-based imaging applications. During our studies of GFP-like proteins from the Great Barrier Reef corals, several novel photoactivatable (PA) GFP-like proteins have been discovered. These include fluorescence photo-amplifiers and reversible photoswitchers, similar to PA jelly-fish derived PA-GFP and Dronpa, that greatly increase their emissions following ultraviolet-A (UVA) irradiation; the red-to-green (R-to-G) converters, similar to DsRed, that rapidly change to green color following single- or 2-photon irradiation; the green-to-red (G-to-R) converters, that acquire bright red fluorescence following UV-violet irradiation, similar to Kaede-like proteins; and the kindling GFP-like proteins, that are non fluorescent, but rapidly acquire bright fluorescence after green light irradiation. We report on the various optical characteristics of these coral PA proteins that may be used to expand the scope of the available fluorescence bio-imaging technologies.
Advances in the control of a "smart tube" high power backward wave oscillator (2003)

Previous accomplishments pertaining to the control of various parameters of an intense beam-driven relativistic backward wave oscillator (BWO) include maintaining a specified or desired output power over a determined frequency bandwidth, and maintaining a constant frequency over a wide range of power. This was accomplished using an iterative learning control (ILC) algorithm that yielded the appropriate input variables for the electron beam, as well as the appropriate displacement of the slow wave structure from the cutoff neck. A problem of much greater complexity is the simultaneous control of both frequency and power, involving the independent mapping of both power and frequency dependence on the two input variables: cathode voltage and slow wave structure displacement. The resultant two-variable system has been successfully implemented and tested for convergence with minimal iterations. In this paper we present an overview of our "smart tube," its development, and our most recent results.
Effect of adding a multifunctional acrylate on the electro-optical properties of reflection gratings formed by thiol-ene photopolymerization (2004)

Thiol-ene photopolymerization reactions initiated by a UV Argon laser line were used to write Bragg reflection gratings in polymer dispersed liquid crystals. Thiol-ene polymers are well suited as hosts for grating formation as they exhibit good long-term stability in their optical and electro-optical properties. Gelation in thiol-enes occur at high conversions (> 50%) and phase separation leads to formation of spherically shaped nematic droplets. For conventional photopolymerization using acrylates, high molecular weight polymer is formed very early in the reaction and therefore gelation occurs at low conversions. In this study, we have observed the effect of adding a multifunctional acrylate to the commercially available Norland thiol-ene precursors on the formation of Bragg reflection gratings. The results suggest a preferential homopolymerization of acrylate leading to early gelation that adversely affects the performance of the reflection gratings. A decrease of diffraction efficiency, an increase of switching voltage, and higher levels of shrinkage of the polymerizing film was observed. Morphology studies indicate with increasing addition of acrylate, a progressive transition from spherical nematic droplets to elongated droplets occurs with decrease of droplet density.
Brief Report (2015)

Association of HIV-1-specific T-cell responses to infection risk in seronegative individuals is controversial. We quantified and phenotypically characterized gp120-specific T-cell responses in HIV-1 exposed, but uninfected subjects enrolled in the global Pre-exposure Prophylaxis Initiative (iPrEx) chemoprophylaxis trial. IFNγ ELISpot responses were detected in 24% of subjects irrespective of infection outcome. HIV-1 gp120 envelope-specific T-cell responses were more uniformly IFN-γ+TNF-α+Mip-1β+ in persistently seronegative subjects relative to subjects who later seroconverted (median frequency of 76.5% and 66.5%, respectively). IFNγ responses targeted the V2 loop for subjects who remained seronegative. HIV-1 gp120 envelope V2 loop-specific CD8 T-cell responses may help to protect against HIV-1 acquisition.
Capacity of low power multiuser systems with antenna arrays (2005)

In this thesis, we study wireless multiuser communication systems in the regime of low spectral efficiencies, where users and the multiple access point are equipped with antenna arrays. Our first contribution is to develop a generic mathematical framework which captures tradeoffs between fundamental parameters of a low power multiuser system: spectral efficiency and energy per information bit, of each user.\nUsing the framework that we developed we next consider variable data rate multiple access problem, in low power systems, where we remove the usual assumption of tight user coordination, and we allow users to select their own data rates and trans mit powers, without coordinating, and without negotiating with the access point. Here, every user has a set of low power codebooks, that we name the policy, which accommodates a range of small spectral efficiencies, but particular data rates of other users are assumed to be an unknown---compound parameter---at each mobile. In antenna-array transmission and reception, we demonstrate an elegant interpretation of users policies, where each policy is represented by partitioning spatial dimensions into blocks, and each block is dedicated to a different user.\nFinally, we address the paradigm of statistically correlated antenna arrays, where we derive the effective number of uncorrelated receive spatial dimensions, which we partition to represent users policies. As more correlated antennas are packed into a limited area we show that effective receive dimensionality converges to a finite limit which we evaluate for some simple geometries.
Heterojunction Waveguide Photodetectors (1987)

Conventional PIN detectors have bandwidth efficiency products of up to 38 GHz. This product is primarily limited by the hole transit time through the depleted layer. We describe a pInP/nInGaAsP/nInP heterojunction waveguide PIN photodetector that provides for light absorption perpendicular to current collection, a feature that results in high-speed, high-efficiency and relatively bias-insensitive operation. The 30 &mu;m waveguide length corresponds to 6 absorption lengths, assuming an optical confinement of 30% and a material absorption coefficient of 0.7 &mu;m.-1 Our uncoated, packaged device has an impulse response of 40 ps (Tektronix S-4 sampling head) and efficiency of 25% at zero bias.
Accuracy of robotic coil positioning during transcranial magnetic stimulation (2019)

Robotic TMS systems can provide accurate and stable coil position and orientation in long TMS sessions. Lack of pressure feedback and of manual adjustment of all coil degrees of freedom were limitations of this robotic system.
Effect of stage of lactation and milk accumulation on mammary cell differentiation in lactating bats (1992)

Mammary cell differentiation was measured in lactating pipistrelle bats (Pipistrellus pipistrellus) by assay of key enzyme activities, and by determination of protein and lactose synthesis rates in short-term tissue cultures. By these criteria, mammary cell differentiation did not change significantly with stage of lactation, but depended on the extent to which the gland was filled with milk. Key enzyme activities and in vitro synthesis rates were significantly higher in glands suckled immediately before tissue collection, compared with contralateral glands that were engorged with milk. This indicates that mammary cell differentiation in the lactating bat is regulated locally within each gland by a mechanism sensitive to milk accumulation, to the extent that, unlike other species, this obscures any underlying effect of stage of lactation.
A novel concept for ultra-low capacitance via-last TSV (2010)

In this study, we report a new concept of through silicon via for 3D applications requiring ultra-low coupling capacitance. The challenges linked to the integration of such structure, as well as preliminary results on stress level and distribution in the TSV are addressed in details below.
System-Level Study of Data Duplication Enhancements for 5G Downlink URLLC (2019)

Data duplication is studied as a fundamental enabler for ultra-reliable low-latency communication (URLLC) in fifth-generation cellular systems. It entails the simultaneous usage of multiple radio links delivering redundant data between a terminal and the network to boost the transmission reliability. However, the improved reliability comes at a cost of reduced spectral efficiency, since the transmission of multiple instances of the data message on different links occupies more radio resources as compared to sending only one instance using a single link. It is therefore crucial to improve the performance of data duplication schemes, with the aim of reducing the radio resource consumption without degrading the reliability gain provided by this transmission paradigm. In this paper, we propose several methods to increase the downlink URLLC capacity supported by data duplication in fifth-generation cellular networks based on the New Radio standard. A single-user analytical model is derived to evaluate a combination of the proposed enhancements. The most promising solution, namely selective data duplication upon failure which entails a massive reduction of the overall number of duplicate transmissions, is finally evaluated by means of extensive multi-user system-level simulation campaigns. The simulation results with background mobile broadband traffic show that, in the investigated scenario, the proposed solution with 4 Mbps offered URLLC traffic outperforms the baseline approach for data duplication with 1 Mbps offered URLLC traffic, thus increasing the amount of URLLC user equipments that can be effectively sustained by the network.
Reflection Characteristics of Type II FBG Made With Femtosecond Radiation (2012)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text D. Grobnic, S. J. Mihailov, R. B. Walker, and C. W. Smelser, "Reflection Characteristics of Type II FBG Made With Femtosecond Radiation," in Advanced Photonics Congress, OSA Technical Digest (online) (Optica Publishing Group, 2012), paper BM2D.5. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Circulating lymphocyte subsets linked to intracellular cytokine profiles in normal humans (2003)

To determine whether there is an association between intracellular cytokine profiles and the expression of surface antigens, we performed a simultaneous flow cytometric analysis of these laboratory parameters in 11 healthy volunteers. Peripheral blood lymphocytes were double-stained for CD4 or CD8, as well as CD11a, CD25, CD26, CD29 and CD45RA or the chemokine receptors CCR3, CCR4, CCR5 or CXCR3. Portions of the cell samples were cultured for 4 h in the presence of 1 microm monensin and 20 microg/ml brefeldin A with or without stimulation by phorbol myristate acetate plus ionomycin for the detection of intracellular interferon-gamma (IFN-gamma), interleukin-2 (IL-2), tumour necrosis factor (TNF)-alpha, and IL-4. As a result, CD4+CD29high helper inducer T cells were closely associated with IFN-gamma and TNF-alpha producing CD4+ cells, while CD4+CXCR3+ cells showed a negative correlation with IL-4-producing cells, suggesting that both of these CD4+ subsets consist mainly of Th1 cells. In contrast, CD4+CD45RA+ cells were correlated inversely with IFN-gamma and TNF-alpha-producing cells, and CD8+CD11ahigh killer effector and total CCR5+ cells showed an inverse correlation with IL-2 producing cells, suggesting an immunoregulatory role for these three subsets in non-pathological conditions. Therefore, monitoring of lymphocyte subsets that express functional surface antigens could provide additional information concerning immune deviation, as assessed by the production of Th1/Th2 type cytokines. Further, this type of combined study may provide clues for the pathogenesis of immune-mediated disorders.
Detection of small bleeds in the brain with electrical impedance tomography (2016)

In this paper, we describe and assess feasibility of instrumentation and algorithms for detecting bleeding due to hemorrhagic strokes and traumatic brain injury using electrical impedance tomography, a novel biomedical diagnostic modality in which the body is probed noninvasively with generally imperceptible alternating currents applied in patterns to a set of electrodes placed in contact with the skin. We focus on the GENESIS instrument developed by GE Global Research and on the achievability of our goal to detect a bleed in the center of the head with a volume of several ml. Our main topic is compensation for the large changes in voltages that tend to occur when the electrodes are in contact with biological media, specifically either human subjects or with vegetable matter proxies which seem to exhibit the same 'drift' phenomenon. We show that these changes in voltages can be modeled by assuming that each electrode is attached to the body via a discrete complex impedance whose value is time-varying and describe how this discrete component value can be estimated and largely compensated-for. We compare this discrete model with changes in contact impedances estimated using the complete electrode model showing that the two models are roughly comparable in their ability to explain the data from a single human subject experiment with electrodes attached to the head. In a simulation study, we demonstrate that it is possible to detect a small bleed in the center of the head even in the case of large changes in electrode impedances, which can be treated as nuisance parameters.
Delaminated Zeolites: An Efficient Support for Enzymes (2002)

Delaminated zeolites (see, e.g., Figure) have been proposed as excellent supports for enzymes. This type of material presents suitable physicochemical properties such as a very high, hydroxylated, and ordered external surface, and good thermal stability. Here we describe the method of preparation of delaminated materials and surface immobilization of enzymes, as well as the remarkable activity and stability of the final products.
Supplementary Figure S3 from Adiponectin Receptor Signaling on Dendritic Cells Blunts Antitumor Immunity (2023)

&lt;p&gt;Both APN receptors can independently modulate DC function.&lt;/p&gt;
Vertical beamforming for three-dimensional user placement (2015)

Full-dimensional multiple input multiple output (FD-MIMO) is a practical implementation of massive MIMO in cellular communication systems. FD-MIMO relies on a planar array of active antenna systems (AAS) at the base stations to harvest the benefits of both azimuth and vertical beamforming. In this paper, we analyze the network performance of per-user vertical beamforming with a special focus on the three-dimensional placement of the base stations and the users. We use tools from stochastic geometry to analyze the coverage performance of cellular networks with a three-dimensional radiation pattern at the base stations, using AAS. We show that the directionality achieved via dynamic antenna tilting provides multi-fold improvement in network performance as compared to omni-directional digital beamforming. We draw insights on the performance of the network as a function of the height difference between the base stations and the users, the number of antennas at the base station, and the various characteristics of the radiation pattern.