gebhart/patrepeval huggingface dataset:
Cyclooxygenase-1 and -2 Knockout Mice Demonstrate Increased Cardiac Ischemia/Reperfusion Injury but Are Protected by Acute Preconditioning (2001)

Genetic disruption or 2-day chemical inhibition of COX-1 and COX-2 decreases recovery of LVDP after ischemia; however, acute perfusion with indomethacin is not detrimental. These data are consistent with protection due to the altered expression of some protein that is modulated by COX or its metabolites.
Insertable cardiac monitoring results in higher rates of atrial fibrillation diagnosis and oral anticoagulation prescription after ischaemic stroke (2023)

Patients with an ischaemic stroke monitored with an ICM were almost three times more likely to be diagnosed with AF and to be prescribed OAC compared to patients who received ECM only.
Vitamin D hypovitaminosis and efficacy of supplementation in spine surgery patients (2019)

Background: Although there is evidence that hypovitaminosis D is present in many otherwise healthy adults, there is little information on supplementation in patients undergoing spine surgery. Thus, the purpose of this study was to determine the prevalence of preoperative hypovitaminosis D in spine surgery patients and evaluate the efficacy of postoperative vitamin D supplement regimens. Methods: Per standard of care, serum 25-hydroxyvitamin D levels were regularly drawn preoperatively and at 6 mo postoperatively; patients with hypovitaminosis D were prescribed a 3-month supplementation regimen based on their level of deficiency: 2000 IU/day, 50,000 IU/wk, or both 50,000 IU/wk and 2000 IU/day. For this analysis, we retrospectively reviewed charts of patients who had spine surgery to identify those with preoperative vitamin D levels. Rates of hypovitaminosis D were compared before and after treatment with supplementation. Results: Of 853 patients with preoperative serum vitamin D levels, 505 (59.2%) had hypovitaminosis D (&lt;30 ng/mL). The rate of insufficiency (20-29 ng/mL) was 31.5%, and the rate of deficiency was 27.7%. At 6 mo postoperatively, the mean serum vitamin D level of patients with hypovitaminosis D increased from 19.7 ng/mL to 30.0 ng/mL ( P &lt;0.001). However, only 42.6% of patients achieved sufficiency at 6 mo. There were no differences in improvements between the supplementation regimens. Conclusions: Hypovitaminosis D is common among patients undergoing spine surgery. Patients should be tested preoperatively and prescribed a supplementation for at least 3 mo postoperatively. Serum levels should be checked regularly postoperatively, especially in deficient patients, to determine if further treatment is needed.
Developmental characterization of thefasciatedlocus and mapping ofArabidopsiscandidate genes involved in the control of floral meristem size and carpel number in tomato (2006)

Mutation at the fasciated locus was a key step in the production of extreme fruit size during tomato domestication. To shed light on the nature of these changes, near-isogenic lines were used for a comparative developmental study of fasciated and wild-type tomato plants. The fasciated gene directly affects floral meristem size and is expressed before the earliest stages of flower organogenesis. As a result, mature fruit of fasciated mutants have more carpels (locules) and greater fruit diameter and mass. The discovery that fasciated affects floral meristem size led to a search for candidate genes from Arabidopsis known to be involved in floral meristem development. Putative homologs were identified in a large tomato EST database, verified through phylogenetic analyses, and mapped in tomato; none mapped to the fasciated locus; however, putative homologs of WUS and WIG mapped to the locule number locus on chromosome 2, the second major transition to large tomato fruit, with WUS showing the highest association. In other cases, minor QTLs for floral organ number (lcn2.2) and (stn11.2) co-localized with a CLV1 paralog and with the syntenic region containing the CLV3 gene in Arabidopsis, respectively.
Microelectromechanical Systems Resonator Utilizing Torsional-to-Transverse Vibration Conversion (2011)

A silicon microelectromechanical systems (MEMS) resonator utilizing the torsional-to-transverse vibration conversion is designed, fabricated and evaluated. The resonant frequency for the torsional modes mostly depends on only beam length, providing a large tolerance in the fabrication process. It has been, however, a critical issue to investigate the mechanism for generating the torsional vibration and the reduction of motional resistance. We propose a new beam structure, in which four torsion beams are vibrated by twist force generated by a transverse beam. The novel process for fabricating resonators provides a narrow gap surrounded by flat surfaces, which can reduce the motional resistance. The fabricated resonators are measured with a laser-Doppler (LD) vibrometer. The scanning function of the LD vibrometer confirms the torsional-to-transverse vibration conversion has been successfully achieved. The measured resonant frequency, 10.96 MHz, is in good agreement with the simulated one. The Q-factor has been also measured to be as high as 2.2 ×104 in vacuum. The electrical characteristic is evaluated with an impedance analyzer. At the resonant frequency, the extracted motional resistance for the 0.5-µm-gap resonator is 2.0 MΩ, which is greatly reduced, owing to the narrow gap effect, from that of the 1-µm-gap resonator. The temperature coefficient of the resonant frequency between -40 and 85 °C, has been measured to be -24.4 ppm/deg. The resonant frequency linearly decreases as the temperature rises.
I am a smartphone and i can tell my user's walking direction (2014)

This paper describes WalkCompass, a system that exploits smartphone sensors to estimate the direction in which a user is walking. We find that several smartphone localization systems in the recent past, including our own, make a simplifying assumption that the user's walking direction is known. In trying to relax this assumption, we were not able to find a generic solution from past work. While intuition suggests that the walking direction should be detectable through the accelerometer, in reality this direction gets blended into various other motion patterns during the act of walking, including up and down bounce, side-to-side sway, swing of arms or legs, etc. Moreover, the walking direction is in the phone's local coordinate system (e.g., along Y axis), and translation to global directions, such as 45 degree North, can be challenging when the compass is itself erroneous. WalkCompass copes with these challenges and develops a stable technique to estimate the user's walking direction within a few steps. Results drawn from 15 different environments demonstrate median error of less than 8 degrees, across 6 different users, 3 surfaces, and 3 holding positions. While there is room for improvement, we believe our current system can be immediately useful to various applications centered around localization and human activity recognition.
4D iterative reconstruction in cardiac CT (2012)

In this paper, a 4D iterative reconstruction scheme is developed to improve noise characteristics and/or reduce radiation exposure in multi-slice cardiac CT. In our implementation, image volume datasets are reconstructed at adjacent temporal positions with respect to an optimized cardiac phase (best phase). Nonlinear regularization priors operate on a 4D cube surrounding each voxel in 4D space, reducing image noise while maintaining temporal and spatial image sharpness. The temporal resolution of image data is maintained despite the usage of temporal data that can substantially exceed the reconstruction range of the 'best phase' reconstruction. Consequently, the noise statistics is significantly improved because non-correlated image data at different temporal positions are utilized. To reduce the high computational load, the iterative regularization in 4D can be transferred into image space. Raw data based Iterative Reconstruction reducing artifacts due to the non-exactness of the backprojector is decoupled from regularization and restricted to only those projection data belonging to the 'best phase' reconstruction. Finally, the image formation is achieved by a normalized combination of the low frequency part of the raw data based Iterative Reconstruction at cardiac best phase and the high frequency part of the image based regularization image at best phase. We demonstrate the potential of noise reduction on basis of clinical cardiac CT data. As an example for cardiac dual source CT (DSCT) data a noise reduction up to 70% was achieved. Even in case of a very high and irregular heart beat with an average heart rate of 115 bpm the high temporal resolution of DSCT could be maintained.
Localization of follicle regulatory protein in the porcine ovary. (1988)

The granulosa cell secretes a protein (follicle regulatory protein: FRP) that affects the responsiveness of other follicles to gonadotropin stimulation. This protein was purified, partially characterized, and rabbit antisera as well as monoclonal antibodies were prepared against FRP. Fixed sections of porcine ovaries were prepared on slides and then incubated with the monoclonal antibody or polyclonal antisera and then incubated with either biotinylated mouse IgM or rabbit IgG antisera, respectively. These sections were then incubated with avidin conjugated to horseradish peroxidase, followed by substrate. Staining with both the monoclonal antibody and the antisera was present in the cytoplasm of granulosa cells of small- or medium-sized antral follicles. Staining distribution was localized preferentially to cells near the basal lamina; the antral granulosa cells of viable follicles did not stain. Neither primordial follicles nor pre-antral follicles (less than 300 microns in diameter) showed any positive staining. Thecal cells were not stained in follicles less than 5 mm in diameter, whereas some large follicles (greater than 5 mm) contained staining in the theca. In the latter, specific granulosa staining was only weakly positive with the polyclonal antibody and negative with the monoclonal antibody. Atretic follicles contained significant staining of all epithelial cells adjacent to the basal lamina by both the monoclonal and polyclonal antibody preparations. Staining of the luteal ovary by the monoclonal antibody was limited to the large luteal cells. These findings suggest that FRP is produced by the granulosa cells of porcine follicles at the stage of maturation corresponding to 0.5 mm in diameter. As the viable follicle increases in size, production of FRP in the granulosa is reduced below the detectable level when the follicle exceeds 5 mm in diameter. The main source of FRP during the luteal phase is the large cell of the corpus luteum.
Adjuvant Sirolimus Does Not Improve Outcome in Pet Dogs Receiving Standard-of-Care Therapy for Appendicular Osteosarcoma: A Prospective, Randomized Trial of 324 Dogs (2021)

In a population of pet dogs nongenomically segmented for predicted mTOR inhibition response, sequentially administered adjuvant sirolimus, although well tolerated when added to a backbone of therapy, did not extend DFI or survival in dogs with appendicular osteosarcoma.
Comparative delay, noise and energy of high-performance domino adders with stack node preconditioning (SNP) (2002)

Stack node preconditioning (SNP) and "mutex" techniques for charge-sharing noise reduction are incorporated into the critical path gates containing transistor stacks in 32-bit domino adders to simultaneously improve best achievable performance by 10% and reduce charge-sharing noise by 2/spl times/ in circuits containing transistor stacks.
Thermal Transport Across Al-(AlxGa1-x)2O3 and Al-Ga2O3 Interfaces (2021)

Abstract (AlxGa1−x)2O3 and Ga2O3 are promising wide bandgap semiconductors for application in power electronics and radio frequency devices because of their exceptional electrical transport properties. However, the heat dissipation in these devices will be limited by the ultra-low thermal conductivity of (AlxGa1−x)2O3 and Ga2O3. Previous studies showed that these devices could achieve high power density with double-sided or top-side cooling strategies. Therefore, the thermal transport across metal-(AlxGa1−x)2O3 and metal-Ga2O3 contacts is important, since heat will be conducted through the metal-semiconductor interface as a preferred pathway to extract heat from the devices. In this work, we study the thermal transport across Al-(AlxGa1−x)2O3 and Al-Ga2O3 interfaces with an (010) orientation for the semiconductors. We have applied thermal and material characterization (time-domain thermoreflectance (TDTR) and high-resolution transmission electron microscopy (HRTEM) together with theoretical approaches to understand the interfacial thermal transport at Al-(AlxGa1−x)2O3 and AlGa2O3 contacts. It is found that for different growth methods, the highest TBC at Al-Ga2O3 interface occurs with molecular beam epitaxy (MBE) deposition of the Al on Ga2O3. However, the experimentally measured TBC at E-beam evaporated Al interfaces is much lower than that at the MBE grown Al interfaces. The measured values are also much lower than theoretical predictions, and it is related to the interfacial chemical reactions that occur at the interfaces. The effect of Al composition on interfacial thermal transport at Al/(AlxGa1−x)2O3 interface is also studied. It is found that the TBC at the E-beam evaporated Al/(AlxGa1−x)2O3 interface is very close to that of the E-beam evaporated Al-Ga2O3 interface at different temperatures in the ternary alloy studied.
Parametrization and Estimation of High-Rank Line-of-Sight MIMO Channels with Reflected Paths (2022)

High-rank line-of-sight (LOS) MIMO systems have attracted considerable attention for millimeter wave and THz communications. The small wavelengths in these frequencies enable spatial multiplexing with massive data rates at long distances. Such systems are also being considered for multi-path non-LOS (NLOS) environments. In these scenarios, standard channel models based on plane waves cannot capture the curvature of each wave front necessary to model spatial multiplexing. This work presents a novel and simple multi-path wireless channel parametrization where each path is replaced by a LOS path with a reflected image source. The model fully is valid for all paths with specular planar reflections and captures the spherical nature of each wave front. Importantly, it is shown that the model uses only two additional parameters relative to the standard plane wave model. Moreover, the parameters can be easily captured in standard ray tracing. The accuracy of the approach is demonstrated on detailed ray tracing simulations at 28 GHz and 140 GHz in a dense urban area.
An Investigation into the Mechanism of Action of Almitrine on Isolated Rat Diaphragm Muscle Fatigue (2002)

The results of this study confirm that almitrine enhances recovery from fatigue and, in contrast to NAC prefatigue application, is more effective. Also, almitrine was shown to have an anti-oxidant effect, but it does not act like a typical anti-oxidant.
Exchange Bias and Domain Evolution at 10 nm Scales (2010)

For a fixed 2 μm×2 μm area of a Co/Pt-CoO perpendicular exchange bias system we image the ferromagnetic (FM) domains for various applied fields with 10-nm resolution by magnetic force microscopy (MFM). Using quantitative MFM we measure the local areal density of pinned uncompensated spins (pinUCS) in the antiferromagnetic (AFM) CoO layer and correlate the FM domain structure with the UCS density. Larger applied fields drive the receding domains to areas of proportionally higher pinUCS aligned antiparallel to FM moments. The data confirm that the evolution of the FM domains is determined by the pinUCS in the AFM layer, and also present examples of frustration in the system.
Comparative Study of Titanium Dioxide Atomic Layer Deposition on Silicon Dioxide and Hydrogen-Terminated Silicon (2010)

Atomic layer deposition (ALD) of amorphous titanium dioxide (TiO2) at 100 °C using the precursors titanium tetrachloride (TiCl4) and water (H2O) was studied on two different surfaces by in situ X-ray photoelectron spectroscopy (XPS). The initial growth rate on hydroxyl-enriched silicon dioxide (SiO2) is found to be higher than on hydrogen-terminated silicon. Moreover, the data show that the growth rate is accelerated during the first several ALD cycles on both surfaces. The interface between the SiO2 substrate and TiO2 is abrupt and composed of Si−O−Ti bonds. On the hydrogen-terminated silicon surface, the XPS results provide evidence of direct Si−Ti bond formation without traces of interfacial oxide. However, a silicon oxide layer forms on this surface after vacuum annealing, concurrent with the reduction of TiO2, suggesting that the TiO2 film is the oxygen source for the silicon oxidation under these conditions. Chlorine incorporates into the TiO2 films on both surfaces and is found to concentrate near the Si/TiO2 interface.
STUDY ON EVALUATION METHOD OF CO<sub>2</sub> ABSORPTION AND PHYSICAL PROPERTIES OF CEMENTITIOUS MATERIALS WITH CARBONATION CURING (2021)

強制的に炭酸化したセメント系材料におけるCO2固定量を定量的に評価することを目的に，高炉スラグ微粉末およびγ-2CaO・SiO2をセメント代替として用いたセメント系材料を，炭酸化が進行しやすい高温，低湿度，高CO2濃度の環境下で炭酸化養生し，CO2固定量を各種分析手法によって評価した．その結果，コンクリートのCO2固定量の評価には熱分析よりも無機炭素分析が適していることを確認した．また，高炉スラグ微粉末およびγ-2CaO・SiO2をセメント代替として用いたコンクリートを炭酸化養生することで，大量のCO2を固定できることを明らかにした．さらに，このコンクリートの空隙率や圧縮強度が，一般的なコンクリートと同程度であることを確認した．
Ehrlichia ruminantium detection using efficient high-throughput molecular method. [0088] (2017)

In order to improve sample screening capacity and E. ruminantium molecular diagnostics, an automated DNA extraction method for Amblyomma ticks and a new qPCR targeting the pCS20 gene region were successfully developed. A comparison between the new pCS20 Sol1 qPCR (both Sybergreen and Taqman chemistries (TqM)), a previously published pCS20 CowTqM qPCR and the pCS20 nested PCR was carried out. pCS20 Sol1TqM qPCR was found to be as specific as the nested PCR with limited sample contamination and significant gain of time. Concerning the specificity, it did not detect Rickettsia, Anaplasma and Babesia species nor Panola Mountain Ehrlichia, E. chaffeensis and E. canis. In parallel, a tick 16SSG rDNA qPCR was developed for DNA extraction control, showing a good reproducibility of the automatic extraction. The whole method, including the automated DNA extraction and pCS20 Sol1TqM qPCR, demonstrated to be sensitive, specific and highly reproducible with the same limit of detection as the manual DNA extraction and nested PCR. Finally, it allows for 96 samples to be tested in one day compared to four days for manual DNA extraction and nested PCR. The development of a new automated DNA extraction using a DNA/RNA viral extraction kit and qPCR enhances the accuracy of E. ruminantium epidemiological studies, as well as allowing for the improvement of diagnostic capabilities and enhanced turn-over time for heartwater surveillance. In addition, the new method opens new opportunities for large-scale screening of other bacteria and viruses in ticks as well as tick genetic characterization and co-evolution studies.(Texte intégral)
The Need for a Robust Precise Time and Frequency Alternative to Global Navigation Satellite Systems (2012)

Positioning, Navigation, and Timing (PNT) services are key enablers of both essential safety and security applications and economically beneficial capacity and efficiency applications worldwide. Whether users are ground-based, sea-based or in the air, their primary/go-to source of PNT has become a Global Navigation Satellites System (GNSS), with the US Global Positioning System (GPS) being the most widely used. Starting in 2001, with the publishing of the landmark Volpe Transportation Systems Center’s GPS Vulnerability Report and leading up to the Department of Homeland Security sponsored GPS Interference Testing in 2012, the world has became much more aware of the vulnerability of GNSS-based services – especially in 2011, as the result of significant interest in using the spectrum directly adjacent to GPS for mobile communications services. This was an important wake up call to the world. But while users of GNSS positioning and navigation services are usually at least cognizant of the source of their services, many users of GPS precise time and frequency are oblivious to both the source of these services and their inherent vulnerability. In fact many time and frequency users are not even aware of how GNSS-provided time is crucial to their operations. The Federal Aviation Administration (FAA) has initiated an Alternate Position, Navigation, and Timing (APNT) program to research various alternative strategies. These strategies are necessary to ensure a safe, secure, and effective transition of the US National Airspace System (NAS) to the Next Generation Air Transportation System (NextGen). While discussing some of the position and navigation aspects of this program, this paper concentrates on the need for a robust time and frequency alternative to GNSS that will support aviation and have the potential to provide robust precise time and frequency services to other user communities. Alternatives strategies to be explored include use of existing NAS ground-based navigation aids, high power ground waves, antenna technologies, and alternative satellite constellations.
Neurokinin 1 receptors and neprilysin modulation of mouse bladder gene regulation (2003)

Neurokinin 1 (NK(1)) receptors play a fundamental role in neurogenic inflammation. We sought to determine the mechanisms downstream from NK(1) receptor (NK(1)R) activation using cDNA arrays and a novel statistical method to analyze gene expression. We used female NK(1)R(-/-) and wild-type (WT) mice that were sensitized actively by intraperitoneal injections of dinitrophenol 4 (DNP(4))-human serum albumin. Cystitis was induced by intravesical instillation of antigen of DNP(4)-ovalbumin, and control mice were challenged with saline. At 1, 4, and 24 h after instillation, bladders were removed for 1) RNA extraction (n = 3), 2) replicate of RNA extraction (n = 3), and 3) morphological analysis (n = 6). For cDNA array experiments, three bladders from each group were homogenized, and total RNA was obtained. DNase-treated RNA was reverse-transcribed to cDNA, labeled with [alpha-(32)P]dATP and hybridized to Atlas Mouse 1.2 Arrays (Clontech). After calculating the mean and SD for background spots, each experimental value was assigned a normalized score S using the formula S' = (S - Av)/SD, where S' is the original pixel value, and Av and SD are the mean and standard deviation of background spots, respectively. Only genes that expressed 3 SD values above background were used. Hypervariable genes were sorted by cluster analysis. Matrices of correlation coefficients were calculated and represented in a connectivity mosaic. As results, we found that in WT mice the most prominent gene cluster had neprilysin in a central position and positively correlated to a group of activator protein-1 (AP-1)-responsive genes, including laminin-alpha3, tissue plasminogen activator 11, fos-B, and TNF-beta. In WT mice, antigen-induced bladder inflammation led to a downregulation in neprilysin expression. In contrast, NK(1)R(-/-) mice failed to mount an inflammatory reaction and presented neprilysin negatively correlated with the same genes described in WT. In conclusion, this work indicates an overriding participation of NK(1)R and neprilysin in bladder inflammation, provides a working model for the involvement of AP-1 transcription factor, and evokes testable hypotheses regarding the role of NK(1)R and neprilysin in inflammation.