gebhart/patrepeval huggingface dataset:
Observation and interpretation of the seafloor vertical electric field in the eastern North Pacific (1985)

A 37 day long recording of the seafloor vertical electric field collected on the East Pacific Rise and south of the mouth of the Gulf of California is examined. The principal barotropic ocean tides are detected by regression analysis and display electric field values that yield typical open ocean water velocities of 1 cm/s or less. Spectral analysis and modeling indicate that internal wave‐induced electric fields consistent with the Garrett‐Munk kinematic description explain the data between the local inertial frequency of 0.033 cph and about 1 cph. At lower frequencies, a variance enhancement near 90 h period of unknown origin is also present. Low but significant coherence of the VEF with land magnetic observatory data is also demonstrated; this is probably due to motion of the electric field instrument in ambient water currents.
Interactions between the breast cancer-associated MUC1 mucins and C-type lectin characterized by optical tweezers (2017)

Carbohydrate-protein interactions govern many crucial processes in biological systems including cell recognition events. We have used the sensitive force probe optical tweezers to quantify the interactions occurring between MGL lectins and MUC1 carrying the cancer-associated glycan antigens mucins Tn and STn. Unbinding forces of 7.6 pN and 7.1 pN were determined for the MUC1(Tn)-MGL and MUC1(STn)-MGL interactions, at a force loading rate of ~40 pN/s. The interaction strength increased with increasing force loading rate, to 27 and 37 pN at a force loading rate of ~ 310 pN/s. No interactions were detected between MGL and MUC1(ST), a glycoform of MUC1 also expressed by breast carcinoma cells. Interestingly, this glycan (ST) can be found on proteins expressed by normal cells, although in this case not on MUC1. Additionally, GalNAc decorated polyethylene glycol displayed similar rupture forces as observed for MUC1(Tn) and MUC1(STn) when forced to unbind from MGL, indicating that GalNAc is an essential group in these interactions. Since the STn glycan decoration is more frequently found on the surface of carcinomas than the Tn glycan, the binding of MUC1 carrying STn to MGL may be more physiologically relevant and may be in part responsible for some of the characteristics of STn expressing tumours.
Electronic Structures of Metal Pentacyanonitrosyls (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic Structures of Metal PentacyanonitrosylsP. T. Manoharan and Harry B. GrayCite this: Inorg. Chem. 1966, 5, 5, 823–839Publication Date (Print):May 1, 1966Publication History Published online1 May 2002Published inissue 1 May 1966https://pubs.acs.org/doi/10.1021/ic50039a027https://doi.org/10.1021/ic50039a027research-articleACS PublicationsRequest reuse permissionsArticle Views340Altmetric-Citations167LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Chinese Model and the Underdeveloped World (1963)

Journal Article The Chinese Model and the Underdeveloped World Get access Roderick MacFarquhar Roderick MacFarquhar Search for other works by this author on: Oxford Academic Google Scholar International Affairs, Volume 39, Issue 3, July 1963, Pages 372–385, https://doi.org/10.2307/2611206 Published: 01 July 1963
Adaptive virtual queue random early detection in satellite networks (2007)

Due to exponential increases in internet traffic, Active Queue Management (AQM) has been heavily studied by numerous researchers. However, little is known about AQM in satellite networks. A microscopic examination on queueing behavior in satellite networks is conducted to identify problems with applying existing AQM methods. A new AQM method is proposed to overcome the problems and it is validated with a realistic emulation environment.
Identification of a Neutralizing Epitope on TOSV Gn Glycoprotein (2021)

Emerging and re-emerging viral infections have been an important public health problem in recent years. We focused our attention on Toscana virus (TOSV), an emergent neurotropic negative-strand RNA virus of the <i>Phenuiviridae</i> family. The mechanisms of protection against phlebovirus natural infection are not known; however, it is supposed that a virus-neutralizing antibody response against viral glycoproteins would be useful to block the first stages of infection. By using an improved memory B cell immortalization method, we obtained a panel of human mAbs which reacted with TOSV antigens. We identified three epitopes of TOSV Gn glycoproteins by neutralizing mAbs using synthetic peptide arrays on membrane support (SPOT synthesis). These epitopes, separated in primary structure, might be exposed near one another as a conformational epitope in their native structure. In vivo studies were conducted to evaluate the humoral response elicited in mice immunized with the identified peptides. The results underlined the hypothesis that the first two peptides located in the NH<sub>2</sub> terminus could form a conformational epitope, while the third, located near the transmembrane sequence in the carboxyl terminus, was necessary to strengthen neutralizing activity. Our results emphasize the importance of identifying neutralizing epitopes shared among the various phleboviruses, which could be exploited for the development of a potential epitope-based diagnostic assay or a polyvalent protective vaccine against different phleboviruses.
Electrocardiogram-gated imaging of a mouse heart using a high-frequency annular array. (2009)

Gated imaging is a technique in which M-mode data, referenced to a feature of an ECG signal, are acquired at a series of lateral positions and then reassembled into B-mode images to achieve high effective frame rates. It is only effective for imaging objects with periodic motion. Annular arrays and synthetic focusing allow for an improved depth of field (DOF) and resolution versus single-element transducers. Here, a five-element, 35-MHz annular array was utilized in combination with ECG and respiratory gating to image adult mouse hearts. An experimental system was assembled to permit appropriate triggering conditions and to collect all 25 transmit-to-receive echo data sets from the annular array at a series of lateral positions. The system was initially tested with a hexagon-shaped target that rotated at 10 revs/s and generated a trigger each rotation. After system testing, data were acquired from an adult mouse heart using a trigger in phase with the R-wave of the ECG signal. The synthetically-focused B-mode images showed several cardiac cycles over a 1200 ms duration captured at 100 fps over a 1-cm depth and a 6-mm width. Data from the mouse heart were acquired with conventional monocycle excitation and also with coded excitation.
Combining field imaging endoscopy with point analysis spectroscopy for improving early lung cancer detection (2008)

We propose to combine field imaging endoscopy with point spectral analysis for improving the overall diagnostic accuracy in clinical lung cancer detection. For this purpose, we developed an integrated endoscopy system that uses autofluorescence imaging and white light reflectance imaging to obtain high diagnostic sensitivity, while at the same time uses non-contact point reflectance/fluorescence spectroscopy to reduce false positive biopsies, thus, achieve high diagnostic specificity. A pilot clinical test on 22 lung patients demonstrated that using this system the malignant lung lesions can be differentiated from the benign lesions with both diagnostic sensitivity and specificity of better than 80%. To further reduce the number of false positive diagnosis and allow even higher diagnostic accuracies, we have also developed an endoscopic laser Raman probe for in vivo real-time biochemical analysis of the suspicious tissue areas identified by the field imaging modalities (white light imaging and autofluorescence imaging). Preliminary Raman spectroscopy results will be reported at the conference.
Multi-standard wideband OFDM RF-PWM transmitter in 40nm CMOS (2015)

A fully digital 0.9GHz-2.6GHz multimode modulator based on the principle of RF-PWM is presented. It makes use of a delay-line based phase modulator which delays an incoming LO-signal with a resolution of 4ps. The modulator is designed to drive highly efficient switching power amplifiers and support carrier frequencies over a wide range. The modulator has been implemented in 40nm CMOS technology. It achieves an EVM of better than -29dB for a 802.11g 64-QAM OFDM signal. It has also been tested with 40MHz single carrier 64-QAM modulated signals. The measured ACPR is below -30dB up to 2GHz and possible improvements are demonstrated.
Benzeneseleninyl Chloride (2001)

[57204-85-0] C6H5ClOSe (MW 207.52) InChI = 1S/C6H5ClOSe/c7-9(8)6-4-2-1-3-5-6/h1-5H InChIKey = UEMZHZLQBGLRFA-UHFFFAOYSA-N (introduction of α,β-unsaturation in ketones and esters;1 oxidation of amines2 and aldoximes;3 halogenation of alkenes4 and aromatic compounds5 with aluminum halides) Physical Data: mp 75 °C. Solubility: sol CH2Cl2, THF. Preparative Method: benzeneseleninyl chloride is obtained from the oxidation of Benzeneselenenyl Chloride in CH2Cl21 or CCl46 with Ozone. Handling, Storage, and Precautions: benzeneseleninyl chloride crystals are extremely hygroscopic and care must be taken to avoid moisture. Solutions in CH2Cl2 are stable for weeks when stored at −15 °C. Selenium compounds are potentially toxic and should be handled in a fume hood.
Tumor Antigen–Specific T-Cell Expansion Is Greatly Facilitated byIn vivoPriming (2007)

Tumor-specific T cells can be efficiently expanded from the peripheral blood ex vivo following in vivo priming with a vaccine. This approach provides an effective method to generate tumor-specific polyclonal T cells for therapeutic use that could be applied to cancer patients with any tumor type.
Ultrasound-mediated piezoelectric differentiation of neuron-like PC12 cells on PVDF membranes (2017)

Electrical and/or electromechanical stimulation has been shown to play a significant role in regenerating various functionalities in soft tissues, such as tendons, muscles, and nerves. In this work, we investigate the piezoelectric polymer polyvinylidene fluoride (PVDF) as a potential substrate for wireless neuronal differentiation. Piezoelectric PVDF enables generation of electrical charges on its surface upon acoustic stimulation, inducing neuritogenesis of PC12 cells. We demonstrate that the effect of pure piezoelectric stimulation on neurite generation in PC12 cells is comparable to the ones induced by neuronal growth factor (NGF). In inhibitor experiments, our results indicate that dynamic stimulation of PVDF by ultrasonic (US) waves activates calcium channels, thus inducing the generation of neurites via a cyclic adenosine monophosphate (cAMP)-dependent pathway. This mechanism is independent from the well-studied NGF induced mitogen-activated protein kinases/extracellular signal-regulated kinases (MAPK/ERK) pathway. The use of US, in combination with piezoelectric polymers, is advantageous since focused power transmission can occur deep into biological tissues, which holds great promise for the development of non-invasive neuroregenerative devices.
Interaction of a designed interleukin‐10 epitope mimic with an antibody studied by isothermal titration microcalorimetry (2001)

The mechanism of recognition of proteins and peptides by antibodies and the factors determining binding affinity and specificity are mediated by essentially the same features. However, additional effects of the usually unfolded and flexible solution structure of peptide ligands have to be considered. In an earlier study we designed and optimized six peptides (pepI to pepVI) mimicking the discontinuous binding site of interleukin-10 for the anti-interleukin-10 monoclonal antibody (mab) CB/RS/1. Three of them were selected for analysis of their solution conformation by circular dichroism measurements. The peptides differ in the content of alpha-helices and in the inducibility of helical secondary structures by trifluoroethanol. These properties, however, do not correlate with the binding affinity. PepVI, a 32-mer cyclic epitope mimic, has the highest affinity to mab CB/RS/1 identified to date. CD difference spectroscopy suggests an increase of the alpha-helix content of pepVI with complex formation. Binding of pepVI to mab CB/RS/1 is characterized by a large negative, favorable binding enthalpy and a smaller unfavorable loss of entropy (DeltaH degrees = -16.4 kcal x mol(-1), TDeltaS degrees = -6.9 kcal x mol(-1)) resulting in DeltaG degrees = -9.5 kcal x mol(-1) at 25 degrees C as determined by isothermal titration calorimetry. Binding of pepVI is enthalpically driven over the entire temperature range studied (10-35 degrees C). Complex formation is not accompanied by proton uptake or release. A negative heat capacity change DeltaC(p) of -0.354 kcal x mol(-1) x K(-1) was determined from the temperature dependence of DeltaH degrees. The selection of protein mimics with the observed thermodynamic properties is promoted by the applied identification and iterative optimization procedure.
On the Single Mono Porous Line Trailing Edge (2023)

View Video Presentation: https://doi.org/10.2514/6.2023-4285.vid This experimental works investigate simplistic porous arrangement at the trailing edge on the aerofoil self-noise radiation. The basis of this works is to utilise the trailing edge geometry to facilitate acoustic interference between two sources that are physically displaced in the longitudinal direction. The study investigated two trailing edge configurations: Baseline (B) and Selective Interference Mono Porous Line trailing Edge (SIMPLE). The experimental results found that SIMPLE trailing edge cases demonstrated the co-existence of destructive and constructive interference between the porous holes and the trailing edge for all free-stream velocities and longitudinal displacements. It was also established that flow communication is necessary to facilitate as a scattering location for acoustic interference. A simple analytical prediction model, based on phase cancellation, has produced good agreement with the experimental results.
Phosphorylation of Histone H3 at Serine 10 Is Indispensable for Neoplastic Cell Transformation (2005)

Very little is known about the role of histone H3 phosphorylation in malignant transformation and cancer development. Here, we examine the function of H3 phosphorylation in cell transformation in vivo. Introduction of small interfering RNA-H3 into JB6 cells resulted in decreased epidermal growth factor (EGF)-induced cell transformation. In contrast, wild-type histone H3 (H3 WT)-overexpressing cells markedly stimulated EGF-induced cell transformation, whereas the H3 mutant S10A cells suppressed transformation. When H3 WT was overexpressed, EGF induction of c-fos and c-jun promoter activity was significantly increased compared with control cells but not in the H3 mutant S10A or S28A cells. In addition, activator protein-1 activity in H3 WT-overexpressing cells was markedly up-regulated by EGF in contrast to the H3 mutant S10A or S28A cells. These results indicate that the phosphorylation of histone H3 at Ser10 is an essential regulatory mechanism for EGF-induced neoplastic cell transformation.
Cell search performance in UTRA (2005)

The performance of the cell search algorithm proposed in UTRA has been evaluated using Monte Carlo simulations. Results indicate that for a handover scenario, synchronisation can in average be achieved within 110 ms for all evaluated environments when the average power of the synchronisation channel equals 0.5 percent of the total transmission in the target cell.
Fast focus-scanning head in two-photon photoacoustic microscopy with electrically-controlled liquid lens (2018)

Conventional one-photon photoacoustic microscopy (PAM) utilizes high-frequency components of generated photoacoustic waves to improve the depth resolution. However, to obtain optically-high resolution in PAM in the depth direction, the use of high-frequency ultrasonic waves is to be avoided. It is because that the propagation distance is shortened as the frequency of ultrasonic waves becomes high. To overcome this drawback, we have proposed and developed two-photon photoacoustic microscopy (TP-PAM). Two-photon absorption occurs only at the focus point. TPPAM does not need to use the high-frequency components of photoacoustic waves. Thus, TP-PAM can improve the penetration depth while preserving the spatial resolution. However, the image acquisition time of TP-PAM is longer than that of conventional PAM, because TP-PAM needs to scan the laser spot both in the depth and transverse directions to obtain cross-sectional images. In this paper, we have introduced a focus-tunable electrically-controlled liquid lens in TP-PAM. Instead of a mechanical stepping-motor stage, we employed electrically-controlled liquid lens so that the depth of the focus spot can be quickly changed. In our system, the imaging speed of TP-PAM using the liquid lens and one-axis stepping-motor stage was 10 times faster than that using a two-axis stepping-motor stage only. TP-PAM with focus-scanning head consisting of the liquid lens and stepping-motor stage will be a promising method to investigate the inside of living tissues.
An Optional Encoding of the BIFT-id Field in the non-MPLS BIER Encapsulation (2018)

Bit Index Explicit Replication (BIER) is an architecture that provides
optimal forwarding through a multicast domain, without
requiring intermediate routers to maintain any per-flow state or to
engage in an explicit tree-building protocol. The Multicast packet is
encapsulated using a BIER Header and transported through an MPLS or
non-MPLS network. When MPLS is used as the transport, the Bit Indexed
Forwarding Table (BIFT) is identified by a MPLS Label. When non-MPLS
transport is used, the BIFT is identified by a 20bit value. This
document describes one way of encoding the 20bit value.
ChemInform Abstract: Diadamantylcarbene in Solution. (1986)

Abstract At 14 K the "C‐labeled Iong‐lived carbene (I) is gen‐erated photolytically from the corresponding diazo compound.
Modeling stem cell population growth: incorporating parameters for quiescence, differentiation and apoptosis (2003)

The use of stem cells in cell-mediated therapies or cell transplantation applications will require a controlled, scalable system for expansion of the cells and for control of cellular differentiation. Modeling stem cell population growth is one step towards developing such a system. Stem cell populations are heterogeneous and include cells which are non-mitotic. In particular, stem cells may be quiescent or mitotically active. The mitotically-active cells may 1) self-renew to give rise to similar cells, or 2) divide asymmetrically to give rise to precursor cells (which become may terminally differentiated). Cell populations also may include non-mitotic cells which are apoptotic. Non-exponential growth of the stem cell population is the result of the non-mitotic fraction. In this study, we extend a non-exponential model to incorporate parameters describing the non-dividing population. In particular, the models incorporate terms to account for 1) cell loss due to apoptosis or necrosis and 2) the non-dividing differentiated state of a cell. Murine muscle-derived stem cells (MDSC) will be used to experimentally test the model assumptions and determine the goodness of fit of the models using nonlinear regression. This analysis illustrates the dynamics of proliferation in stem cell populations where cells are undergoing both self-renewal and differentiation.
Self-assembly of a neutral platinum(ii) complex into highly emitting microcrystalline fibers through metallophilic interactions (2014)

The solvent-assisted self-assembly of a blue-emitting neutral platinum(II) complex into micrometer-long and highly crystalline fibers has been achieved. The aggregates show highly efficient (quantum yield up to 74%) polarized yellow-orange light emission, as a consequence of their high degree of supramolecular order imparted by weak non-covalent intermolecular (metal···metal and π-π) interactions.
30S ribosomal subunits can be assembled in vivo without primary binding ribosomal protein S15 (2006)

Assembly of 30S ribosomal subunits from Escherichia coli has been dissected in detail using an in vitro system. Such studies have allowed characterization of the role for ribosomal protein S15 in the hierarchical assembly of 30S subunits; S15 is a primary binding protein that orchestrates the assembly of ribosomal proteins S6, S11, S18, and S21 with the central domain of 16S ribosomal RNA to form the platform of the 30S subunit. In vitro S15 is the sole primary binding protein in this cascade, performing a critical role during assembly of these four proteins. To investigate the role of S15 in vivo, the essential nature of rpsO, the gene encoding S15, was examined. Surprisingly, E. coli with an in-frame deletion of rpsO are viable, although at 37 degrees C this DeltarpsO strain has an exaggerated doubling time compared to its parental strain. In the absence of S15, the remaining four platform proteins are assembled into ribosomes in vivo, and the overall architecture of the 30S subunits formed in the DeltarpsO strain at 37 degrees C is not altered. Nonetheless, 30S subunits lacking S15 appear to be somewhat defective in subunit association in vivo and in vitro. In addition, this strain is cold sensitive, displaying a marked ribosome biogenesis defect at low temperature, suggesting that under nonideal conditions S15 is critical for assembly. The viability of this strain indicates that in vivo functional populations of 70S ribosomes must form in the absence of S15 and that 30S subunit assembly has a plasicity that has not previously been revealed or characterized.
Effect of corneal hydration on corneal refractive index (2006)

We report the effect of changes in corneal hydration on corneal refractive index using optical coherence tomography. The results demonstrate that the measurement of refractive index is a quantitative indicator of corneal hydration.