gebhart/patrepeval huggingface dataset:
Infected Distal Biceps Tendon Repairs (2007)

Numerous reports address the risk of infection with surgery about the elbow. However, there is little information regarding treatment of infected distal biceps repairs. We reviewed the records of 37 consecutive patients with biceps repairs between January 1, 2000, and January 1, 2005, to identify cases of postoperative infection. Three patients were identified and their records examined to identify the responsible organisms and any forms of treatment. Two patients presented acutely less than 4 weeks after surgery with frank purulence draining from the incision area. The third patient presented 4 months after tendon repair. In both patients with acute infection, the infection resolved without removal of any stitches or hardware. In the patient with chronic infection, the anchoring material was removed because it was no longer holding the biceps tendon to the radial tuberosity. These data suggest acute infections can be treated with antibiotics and débridement without taking down the tendon repair. However, as with any chronic musculoskeletal infection, all foreign material may need removal before a second repair. Our data demonstrate deep infection is not an uncommon complication of distal biceps tendon repairs that initially can be treated without taking down the construct.
Cathode & Electromagnet Qualification Status and Power Processing Unit Development Update for the Ascendant Sub-kW Transcelestial Electric Propulsion System (2020)

A review of the component-level flight qualification efforts and power processing unit development status of the Ascendant Sub-kW Transcelestial Electric Propulsion System (ASTRAEUS) program is presented. Component-level qualification efforts were undertaken for the system’s ultra-compact heaterless LaB6 hollow cathode and electromagnets, both of which employ designs bespoke to ASTRAEUS, as they represent the highest failure risks for the thruster. Through parallel long-duration wear and ignition tests, the ASTRAEUS cathode demonstrated invariant discharge performance over more than 5000 h of operation at its maximum operating current of 4 A and demonstrated more than 25,000 ignition cycles. The ASTRAEUS electromagnets completed their environmental qualification through a demonstration of more than 1200 deep thermal cycles with no indication of coil degradation (the test articles previously completed qualification-level vibration and shock testing). ASTRAEUS’s prototype power processing unit has demonstrated more than 92% total power conversion efficiency and class-leading power density & specific power density of 4.5 W/cm3 & 1670 W/kg, respectively. The various power converters found in the ASTRAEUS power processing unit are reviewed with a focus on the methods by which such high performance was achieved.
MiR-320d: A novel anti-inflammatory miRNA up regulated by corticosteroids (2015)

<b>Introduction:</b> MicroRNAs (miRNA) are small noncoding RNA transcripts that repress gene-expression. Data from the GLUCOLD study showed that miR-320d is down regulated in COPD airway epithelium compared to healthy controls and again upregulated by inhaled corticosteroid treatment in bronchial biopsies from COPD patients. We aimed to identify the role of miR-320d in airway epithelium and further investigate gene targets using the combined gene and miRNA expression data available in the GLUCOLD study. <b>Methods:</b> Affy- miRNA 2.0 and Hugene ST1.0 arrays were performed on bronchial biopsies at baseline and after 6 and 30-month treatment with fluticasone with or without added salmeterol (F/FS) compared to placebo in 69 patients with COPD. MiR-320d was overexpressed in bronchial epithelial BEAS2B cells using miRNA mimics and were then stimulated with 10% cigarette smoke extract (CSE) for 24 hours and pro-inflammatory chemokine IL8 levels were measured using ELISA. <b>Results:</b> Pathway analysis using GeneNetworks identified miR-320d to inversely correlate with genes associated with the innate immune system (p&lt;0.01). Overexpression of miR-320d in BEAS2B cells reduced the inflammatory response to CSE by repressing the release of IL8 (p&lt;0.05, n=6). within line with this, higher miR-320d levels in bronchial biopsies correlated significantly with lower neutrophil cell counts (r=-0.284, p=0.031, n=56), whereas no significant correlations were found with other inflammatory cell populations. <b>Conclusion:</b> Our data suggest that miR-320d is an anti-inflammatory miRNA, which may influence neutrophil infiltration by repressing IL8 release from airway epithelial cells, providing a novel pathway in the regulation of inflammation in the lung.
Analysis of Time Lags and Other Sources of Error of the DexCom SEVEN Continuous Glucose Monitor (2009)

For this sensor, the assumption of substantial time lag and its suggested effects may be incorrect. The main source of error is the calibration process.
Synchronization of nonsolitonic Kerr combs (2021)

Synchronization is a ubiquitous phenomenon in nature that manifests as the spectral or temporal locking of coupled nonlinear oscillators. In the field of photonics, synchronization has been implemented in various laser and oscillator systems, enabling applications including coherent beam combining and high-precision pump-probe measurements. Recent experiments have also shown time-domain synchronization of Kerr frequency combs via coupling of two separate oscillators operating in the dissipative soliton [i.e., anomalous group velocity dispersion (GVD)] regime. Here, we demonstrate all-optical synchronization of Kerr combs in the nonsolitonic, normal GVD regime in which phase-locked combs with high pump-to-comb conversion efficiencies and relatively flat spectral profiles are generated. Our results reveal the universality of Kerr comb synchronization and extend its scope beyond the soliton regime, opening a promising path toward coherently combined normal GVD Kerr combs with spectrally flat profiles and high comb-line powers in an efficient microresonator platform.
EPR Studies of the Binding Properties, Guest Dynamics, and Inner‐Space Dimensions of a Water‐Soluble Resorcinarene Capsule (2015)

Nitroxide free radicals have been used to study the inner space of one of Rebek's water-soluble capsules. EPR and (1) H NMR spectroscopy, ESI-MS, and DFT calculations showed a preference for the formation of 1:2 complexes. EPR titrations allowed us to determine binding constants (Ka ) in the order of 10(7) M(-2) . EPR spectral-shape analysis provided information on the guest rotational dynamics within the capsule. The interplay between optimum hydrogen bonding upon capsule formation and steric strain for guest accommodation highlights some degree of flexibility for guest inclusion, particularly at the center of the capsule where the hydrogen bond seam can be barely distorted or slightly disturbed.
Composite Structures and Materials Research at NASA Langley Research Center (2003)

A summary of recent composite structures and materials research at NASA Langley Research Center is presented. Fabrication research to develop low-cost automated robotic fabrication procedures for thermosetting and thermoplastic composite materials, and low-cost liquid molding processes for preformed textile materials is described. Robotic fabrication procedures discussed include ply-by-ply, cure-on-the-fly heated placement head and out-of-autoclave electron-beam cure methods for tow and tape thermosetting and thermoplastic materials. Liquid molding fabrication processes described include Resin Film Infusion (RFI) Resin Transfer Molding (RTM) and Vacuum-Assisted Resin Transfer Molding (VARTM). Results for a full-scale composite wing box are summarized to identify the performance of materials and structures fabricated with these low-cost fabrication methods.
Supplementary Figures 1A-B from NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis (2023)

Supplementary Figures 1A-B from NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis
High-throughput Caco-2 cell permeability screening by cassette dosing and sample pooling approaches using direct injection/on-line guard cartridge extraction/tandem mass spectrometry (2000)

A method for high-throughput Caco-2 permeability screening of drug candidates has been developed using thirteen generic drugs as test compounds. The high throughput was achieved by either a sample pooling or a cassette dosing approach, along with the use of a rapid, simple and sensitive direct injection/on-line guard cartridge extraction/tandem mass spectrometric assay that was also developed in this study. It was of concern that possible drug-drug interactions (e.g., inhibition of P-glycoprotein-mediated transport of a drug by another, and/or competition of the drugs for transport pathways), when the cassette dosing regimen was implemented, may give rise to inconsistent results compared with those attained by a traditional single-drug dosing approach. However, the apparent permeability coefficients of the test drugs across Caco-2 monolayers measured by the sample pooling or cassette dosing (up to five drugs co-administered in this study) strategy were in good conformity with the data obtained by single-drug dosing followed by discrete sample analysis.
Probing Redox Reactions at the Nanoscale with Electrochemical Tip-Enhanced Raman Spectroscopy (2015)

A fundamental understanding of electrochemical processes at the nanoscale is crucial to solving problems in research areas as diverse as electrocatalysis, energy storage, biological electron transfer, and plasmon-driven chemistry. However, there is currently no technique capable of directly providing chemical information about molecules undergoing heterogeneous charge transfer at the nanoscale. Tip-enhanced Raman spectroscopy (TERS) uniquely offers subnanometer spatial resolution and single-molecule sensitivity, making it the ideal tool for studying nanoscale electrochemical processes with high chemical specificity. In this work, we demonstrate the first electrochemical TERS (EC-TERS) study of the nanoscale redox behavior of Nile Blue (NB), and compare these results with conventional cyclic voltammetry (CV). We successfully monitor the disappearance of the 591 cm(-1) band of NB upon reduction and its reversible reappearance upon oxidation during the CV. Interestingly, we observe a negative shift of more than 100 mV in the onset of the potential response of the TERS intensity of the 591 cm(-1) band, compared to the onset of faradaic current in the CV. We hypothesize that perturbation of the electrical double-layer by the TERS tip locally alters the effective potential experienced by NB molecules in the tip-sample junction. However, we demonstrate that the tip has no effect on the local charge transfer kinetics. Additionally, we observe step-like behavior in some TERS voltammograms corresponding to reduction and oxidation of single or few NB molecules. We also show that the coverage of NB is nonuniform across the ITO surface. We conclude with a discussion of methods to overcome the perturbation of the double-layer and general considerations for using TERS to study nanoscale electrochemical processes.
Editorial Comment (1989)

No AccessJournal of Urology1 Apr 1989Editorial Comment Glenn M. Preminger Glenn M. PremingerGlenn M. Preminger More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)41018-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial Comment." The Journal of Urology, 141(4), pp. 817–818 © 1989 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 141Issue 4April 1989Page: 817-818 Advertisement Copyright & Permissions© 1989 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Glenn M. Preminger More articles by this author Expand All Advertisement PDF downloadLoading ...
Data from <i>miR-152</i> Is a Tumor Suppressor microRNA That Is Silenced by DNA Hypermethylation in Endometrial Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;The etiology and development of human cancers that remain little understood might be enlightened by defining tumor suppressor microRNAs (TS-miRNA). In this study, we identified TS-miRNAs silenced by aberrant DNA hypermethylation in endometrial cancer. Functional screening of 327 synthetic miRNAs in an endometrial cancer cell proliferation assay identified 103 miRNAs that inhibited cell growth. We then determined the sequence, DNA methylation status, and expression levels of these miRNAs in endometrial cancer cell lines and primary tumors. These determinations led to the identification of &lt;i&gt;miR-152&lt;/i&gt; as a candidate TS-miRNA gene in endometrial cancer. Epigenetic silencing documented in &lt;i&gt;miR-152&lt;/i&gt; was consistent with its location at 17q21.32 in intron 1 of the &lt;i&gt;COPZ2&lt;/i&gt; gene, which is also silenced often in endometrial cancer by DNA hypermethylation, and also with evidence that &lt;i&gt;miR-152&lt;/i&gt; targets the &lt;i&gt;DNA methyltransferase DNMT1&lt;/i&gt;. Notably, restoration of &lt;i&gt;miR-152&lt;/i&gt; expression in endometrial cancer cell lines was sufficient to inhibit tumor cell growth &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;. We identified &lt;i&gt;E2F3&lt;/i&gt;, &lt;i&gt;MET&lt;/i&gt;, and &lt;i&gt;Rictor&lt;/i&gt; as novel candidate targets of &lt;i&gt;miR-152&lt;/i&gt;, suggesting how its epigenetic silencing can drive endometrial carcinogenesis. Our findings define a central role for &lt;i&gt;miR-152&lt;/i&gt; in endometrial cancer, and they also suggest its use in new therapeutic strategies to treat this cancer. &lt;i&gt;Cancer Res; 71(20); 6450–62. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Adeno-Associated Virus Type 2 Rep78 Inhibition of PKA and PRKX: Fine Mapping and Analysis of Mechanism (2002)

Hormones and neurotransmitters utilize cyclic AMP (cAMP) as a second messenger in signal transduction pathways to regulate cell growth and division, differentiation, gene expression, and metabolism. Adeno-associated virus type 2 (AAV-2) nonstructural protein Rep78 inhibits members of the cAMP signal transduction pathway, the protein kinases PKA and PRKX. We mapped the kinase binding and inhibition domain of Rep78 for PRKX to amino acids (aa) 526 to 561 and that for PKA to aa 526 to 621. These polypeptides were as potent as full-length Rep78 in kinase inhibition, which suggests that the kinase-inhibitory domain is entirely contained in these Rep peptides. Steady-state kinetic analysis of Rep78-mediated inhibition of PKA and PRKX showed that Rep78 appears to increase the K(m) value of the peptide kinase substrate, while the maximal velocity of the reaction was unaffected. This indicates that Rep78 acts as a competitive inhibitor with respect to the peptide kinase substrate. We detected homology between a cellular pseudosubstrate inhibitor of PKA, the protein kinase inhibitor PKI, and the PRKX and PKA inhibition domains of Rep78. Due to this homology and the competitive inhibition mechanism of Rep78, we propose that Rep78 inhibits PKA and PRKX kinase activity by pseudosubstrate inhibition.
An analytical two-dimensional model for silicon MESFETs (1988)

A model that predicts small-geometry effects in Si MESFETs has been developed. It is based on a two-dimensional (2-D) analytical solution of Poisson's equation in the subthreshold regime that applies to the junction-isolated structure typical of silicon devices. The model is in excellent agreement with numerical simulations from the PISCES 2-D device analysis program. The analytical model provides the physical basis for a subthreshold current model for small-geometry MESFETs. A scaling scheme for MESFETs, derived from the analytical model, that predicts a minimum-acceptable gate length of 0.15 mu m for these devices is proposed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Suppression of Ewing's Sarcoma Tumor Growth, Tumor Vessel Formation, and Vasculogenesis Following Anti–Vascular Endothelial Growth Factor Receptor-2 Therapy (2007)

These results indicated that blocking VEGFR-2 with DC101 antibodies may be a useful therapeutic approach for treating patients with Ewing's sarcoma.
Practical guide on chemometrics/informatics in x-ray photoelectron spectroscopy (XPS). I. Introduction to methods useful for large or complex datasets (2022)

Chemometrics/informatics and data analysis, in general, are increasingly important topics in x-ray photoelectron spectroscopy (XPS) because of the large amount of information (data/spectra) that are often collected in degradation, depth profiling, operando, and imaging studies. In this guide, we discuss vital, theoretical aspects and considerations for chemometrics/informatics analyses of XPS data with a focus on exploratory data analysis tools that can be used to probe XPS datasets. These tools include a summary statistic [pattern recognition entropy (PRE)], principal component analysis (PCA), multivariate curve resolution (MCR), and cluster analysis. The use of these tools is explained through the following steps: (A) Gather/use all the available information about one's samples, (B) examine (plot) the raw data, (C) developing a general strategy for the chemometrics/informatics analysis, (D) preprocess the data, (E) where to start a chemometrics/informatics analysis, including identifying outliers or unexpected features in datasets, (F) determine the number of abstract factors to keep in a model, (G) return to the original data after a chemometrics/informatics analysis to confirm findings, (H) perform MCR, (I) peak fit the MCR factors, (J) identify intermediates in MCR analyses, (K) perform cluster analysis, and (L) how to start doing chemometrics/informatics in one's work. This guide has Paper II [Avval et al., J. Vac. Sci. Technol. A 40, 063205 (2022)] that illustrates these steps/principles by applying them to two fairly large XPS datasets. In these papers, special emphasis is placed on MCR. Indeed, in this paper and Paper II, we believe that, for the first time, it is suggested and shown that (1) MCR components/factors can be peak fit as though they were XPS narrow scans and (2) MCR can reveal intermediates in the degradation of a material. The other chemometrics/informatics methods are also useful in demonstrating the presence of outliers, a break (irregularity) in one of the datasets, and the general trajectory/evolution of the datasets. Cluster analysis generated a series of average spectra that describe the evolution of one of the datasets.
A compact, inexpensive infrared laser system for continuous-wave optical stimulation of the rat prostate cavernous nerves (2014)

Optical nerve stimulation (ONS) has been commonly performed in the laboratory using high-power, pulsed, infrared (IR) lasers including Holmium:YAG, diode, and Thulium fiber lasers. However, the relatively high cost of these lasers in comparison with conventional electrical nerve stimulation (ENS) equipment may represent a significant barrier to widespread adoption of ONS. Optical stimulation of the prostate cavernous nerves (CN’s) has recently been reported using lower cost, continuous-wave (CW), all-fiber-based diode lasers. This preliminary study describes further miniaturization and cost reduction of the ONS system in the form of a compact, lightweight, cordless, and inexpensive IR laser. A 140-mW, 1560-nm diode laser was integrated with a green aiming beam and delivery optics into a compact ONS system. Surface and subsurface ONS was performed in a total of 5 rats, <i>in vivo</i>, with measurement of an intracavernous pressure (ICP) response during CW laser irradiation for 30 s with a spot diameter of 0.7 mm. Short-term, CW ONS of the prostate CN’s is feasible using a compact, inexpensive, batterypowered IR laser diode system. This ONS system may represent an alternative to ENS for laboratory studies, and with further development, a handheld option for ONS in the clinic to identify and preserve the CN’s during prostate cancer surgery.
Thyroid dysfunction after Alemtuzumab treatment for multiple sclerosis: diagnostic and therapeutic modalities (2019)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Liquid storage, shipment, and cryopreservation of cord blood (2004)

Ambient conditions and the packing and processing protocol influence the temperature history of the sample. Samples stored beyond 24 hours in liquid storage and shipping exhibit a decreased postthaw recovery.
Optimal point placement for mesh smoothing (1997)

We study the problem of moving a vertex in an unstructured mesh of triangular, quadrilateral, or tetrahedral elements to optimize the shapes of adjacent elements. We show that many such problems can be solved in linear time using generalized linear programming. We also give efficient algorithms for some mesh smoothing problems that do not fit into the generalized linear programming paradigm.
Magnetic pulse welding of metallic tubes – experimental investigation and numerical modelling (2019)

Magnetic pulse welding (MPW) provides an efficient route to join overlapping metallic tubes by the application of a high magnitude electromagnetic (EM) force. The process is rapidly transient in nature with little scope to comprehend and monitor the evolution of the joint by experimental means. A comprehensive computational process model is presented here to analyse the transient nature of EM field and force, and resulting impact and plastic deformation during MPW of metallic tubes. The computed results are validated with the corresponding experimentally measured weld joint length for specific tube joint geometries. The computed values of the plastic deformation, impact angle and impact velocity along the joint interface are examined further to realise the progressive nature of the joint formation.
Wideband Array Signal Processing with Real-Time Adaptive Interference Mitigation (2023)

&lt;p&gt;A hardware and software pipeline is created to perform wideband interference cancellation through real-time beamforming.&lt;/p&gt;
Nucleoside Diphosphate Prodrugs: Nonsymmetric DiPPro-Nucleotides (2015)

Nonsymmetric DiPPro-nucleotides are described as nucleoside diphosphate (NDP) delivery systems. The concept is to attach different bis(acyloxybenzyl) moieties at the β-phosphate moiety of a NDP. DiPPro compounds bearing two alkanoylbenzyl residues and DiPPro compounds bearing an alkanoylbenzyl or a benzoylbenzyl group as bioreversible prodrug moieties were studied. Compounds bearing short chain alkanoyl esters led to a fast hydrolysis by chemical or enzymatic means. The ester group in the second prodrug group comprised a long lipophilic aliphatic or an aromatic residue. The lipophilicity of this group enabled the prodrug to penetrate the cell membrane. The introduction of two different groups allowed a controlled stepwise removal of the prodrug moieties to achieve a highly selective delivery of the NDP in CEM cell extracts. The compounds were highly active against HIV even in thymidine kinase-deficient CEM cells. Thus, the compounds, although charged at the α-phosphate group, were taken up by the cells and released NDPs.
Kunskap om Vilt och Skog 2 (2012)

• Referenshägn innebär att man jämför vegetationsutvecklingen i en hägnad yta med en oskyddad yta.&#13;\n• Referenshägn byggs med fördel i ungskogsytor där&#13;\neffekterna av betning är särskilt tydliga.&#13;\n• Hjortviltet kan genom bete påverka olika trädslags konkurrensförmåga genom att höjdtillväxten minskar.&#13;\n• Det är framför allt tall och flera arter av lövträd som&#13;\npåverkas negativt av bete medan gran ofta gynnas, vilket&#13;\npå sikt kan få negativa konsekvenser för den biologiska&#13;\nmångfalden.&#13;\n• Genom att använda flera referenshägn kan man mäta vilken&#13;\npåverkan hjortviltet har på vegetation och trädslagssammansättning inom ett viltförvaltningsområde.