gebhart/patrepeval huggingface dataset:
Novel Interconnected Bonded Structure Enhances Proppant Flowback Control (2012)

Abstract Loss of proppant from the near wellbore region of a fracture results in fracture pinch out and a noticeable decrease in well productivity. Downhole and surface equipment can be damaged when proppant flowback occurs as well. Resin coated proppant (RCP), fibers, deformable particles, resin on the fly, etc have been used to improve proppant pack stability. Selection of the appropriate proppant flowback control technology is made with consideration of engineering factors such as fluid compatibility issues, setting time, resistance to cycling stress-loading issues, and conductivity damage. The goal of the current work was to combine the beneficial features of mechanical proppant flowback control with chemical adhesive flowback control products. With mechanical features, the proppant pack stability is enhanced by blending fibers with proppant, thus increasing particle-particle interaction, and increasing the stability of proppant arches. This mechanism can enable aggressive flowback while providing an instantaneous, albeit a modest level of proppant flowback control. With the addition of an adhesive bonding mechanism to a mechanical flowback control material, the bicomponent material substantially increases proppant pack stabilization. Using a high temperature, high pressure proppant flowback control apparatus, we show the impact of particle bonding on the dosing required to achieve a specific level of proppant pack stability. We also show the impact of the flexible nature of bonded matrix on the proppant pack stability and tolerance to cyclic loading. A mechanistic proppant pack stability model was developed based on our experimental study. We discuss this model and its application towards the selection of the appropriate proppant flowback control technology for specific well conditions. We conclude the paper by discussing field cases of effective proppant flowback prevention techniques deployed as a result of model recommendation.
Effect of liposome-encapsulated hemoglobin resuscitation on proteostasis in small intestinal epithelium after hemorrhagic shock (2016)

Gut barrier dysfunction is the major trigger for multiorgan failure associated with hemorrhagic shock (HS). Although the molecular mediators responsible for this dysfunction are unclear, oxidative stress-induced disruption of proteostasis contributes to the gut pathology in HS. The objective of this study was to investigate whether resuscitation with nanoparticulate liposome-encapsulated hemoglobin (LEH) is able to restore the gut proteostatic mechanisms. Sprague-Dawley rats were recruited in four groups: control, HS, HS+LEH, and HS+saline. HS was induced by withdrawing 45% blood, and isovolemic LEH or saline was administered after 15 min of shock. The rats were euthanized at 6 h to collect plasma and ileum for measurement of the markers of oxidative stress, unfolded protein response (UPR), proteasome function, and autophagy. HS significantly increased the protein and lipid oxidation, trypsin-like proteasome activity, and plasma levels of IFNγ. These effects were prevented by LEH resuscitation. However, saline was not able to reduce protein oxidation and plasma IFNγ in hemorrhaged rats. Saline resuscitation also suppressed the markers of UPR and autophagy below the basal levels; the HS or LEH groups showed no effect on the UPR and autophagy. Histological analysis showed that LEH resuscitation significantly increased the villus height and thickness of the submucosal and muscularis layers compared with the HS and saline groups. Overall, the results showed that LEH resuscitation was effective in normalizing the indicators of proteostasis stress in ileal tissue. On the other hand, saline-resuscitated animals showed a decoupling of oxidative stress and cellular protective mechanisms.
Nanoparticle Dispersant Design and Suspension Rheological Properties. (2008)

Abstract not provided.
VNA Balanced Measurements (2020)

Traditionally, common radio frequency (RF) structures involved single-input and single-output devices, with a common ground reference. But with the advent of advanced microwave monolithic integrated circuits and the move to using CMOS technology to higher frequencies, more and more RF circuits are being designed using differential devices. The mixed-mode parameters may also be defined for a 3-port network, comprising one single-ended port and one mixed-mode port, which is usually defined as the differential or balanced port. But, it must be recognized that for a device referenced to ground, a balanced port always has the possibility to support a common mode signal as well. The most common use of a single-ended to differential device is as a balun, used to drive a differential device from a single-ended measurement instrument. With that advent of 4-port vector network analyzers, the need for baluns in characterization of linear, passive measurements was eliminated.
Formation of Supramolecular Hydrogels Induced by Inclusion Complexation between Pluronics and α-Cyclodextrin (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTFormation of Supramolecular Hydrogels Induced by Inclusion Complexation between Pluronics and α-CyclodextrinJun Li, Xu Li, Zhihan Zhou, Xiping Ni, and Kam W. LeongView Author Information Institute of Materials Research and Engineering (IMRE), 3 Research Link, Singapore 117602, and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205 Cite this: Macromolecules 2001, 34, 21, 7236–7237Publication Date (Web):September 12, 2001Publication History Received30 April 2001Revised17 July 2001Published online12 September 2001Published inissue 1 October 2001https://pubs.acs.org/doi/10.1021/ma010742shttps://doi.org/10.1021/ma010742srapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views2179Altmetric-Citations183LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Copolymers,Hydrogels,Polymers,Solution chemistry,Viscosity Get e-Alerts
Tepidicaulis marinus gen. nov., sp. nov., a marine bacterium that reduces nitrate to nitrous oxide under strictly microaerobic conditions (2015)

A moderately thermophilic, aerobic, stalked bacterium (strain MA2T) was isolated from marine sediments in Kagoshima Bay, Japan. Phylogenetic analysis of 16S rRNA gene sequences indicated that strain MA2T was most closely related to the genera Rhodobium,Parvibaculum, and Rhodoligotrophos (92-93 % similarity) within the class Alphaproteobacteria. Strain MA2T was a Gram-stain-negative and stalked dimorphic bacteria. The temperature range for growth was 16-48 °C (optimum growth at 42 °C). This strain required yeast extract and NaCl (>1 %, w/v) for growth, tolerated up to 11 % (w/v) NaCl, and was capable of utilizing various carbon sources. The major cellular fatty acid and major respiratory quinone were C18 : 1ω7c and ubiquinone-10, respectively. The DNA G+C content was 60.7 mol%. Strain MA2T performed denitrification and produced N2O from nitrate under strictly microaerobic conditions. Strain MA2T possessed periplasmic nitrate reductase (Nap) genes but not membrane-bound nitrate reductase (Nar) genes. On the basis of this morphological, physiological, biochemical and genetic information a novel genus and species, Tepidicaulis marinus gen. nov., sp. nov., are proposed, with MA2T ( = NBRC 109643T = DSM 27167T) as the type strain of the species.
Combined Volatolomics for Monitoring of Human Body Chemistry (2014)

Analysis of volatile organic compounds (VOCs) is a promising approach for non-invasive, fast and potentially inexpensive diagnostics. Here, we present a new methodology for profiling the body chemistry by using the volatile fraction of molecules in various body fluids. Using mass spectrometry and cross-reactive nanomaterial-based sensors array, we demonstrate that simultaneous VOC detection from breath and skin would provide complementary, non-correlated information of the body's volatile metabolites profile. Eventually with further wide population validation studies, such a methodology could provide more accurate monitoring of pathological changes compared to the information provided by a single body fluid. The qualitative and quantitative methods presented here offers a variety of options for novel mapping of the metabolic properties of complex organisms, including humans.
Distribution Network Hybrid Transformer for Load Current and Grid Voltage Compensation (2019)

Power quality has become a concern nowadays, due to the increasing and highly variable renewable energy systems connected to the distribution network and also due to the nonlinear loads that pollute the grid. A solution to this problem is the use of compensators to attenuate these disturbances. The use of a hybrid transformer composed by a conventional low-frequency transformer in conjunction with a power converter has become an interesting solution due to the high controllability and overall efficiency. In this paper, the model, control, and simulation of a hybrid transformer, where the converter is connected in series with the primary side and in parallel to the secondary side, is presented. Results show the correct operation of the converter in steady and transient state, successfully compensating grid voltage variations and load non-linear currents.
P2‐157: Memory, Aging and Cognition Centre's Epidemiology of Dementia in Singapore (EDIS) Study: Study Methodology (2011)

The Memory, Aging and Cognition Centre aims to develop a national strategy for detection, care and research for dementia. The Epidemiology theme studies the prevalence of dementia and its subtypes in an elderly multi-ethnic Asian population. The on-going population-based Singapore Epidemiology of Eye Disease (SEED) Programme studies the prevalence of major eye diseases among more than 10,000 randomly-selected adults aged 40-80 years of Chinese, Malay or Indian ethnicity. Participants above 60 years of age undergo cognitive screening using the Abbreviated Mental Test and a self-report of Progressive Forgetfulness. In EDIS, those who screen positive are assessed for dementia according to DSM IV, and invited to a comprehensive clinical assessment, measurement of blood samples, psychometry and neuroimaging. Medical assessment is performed in accordance with established clinical practice guidelines for the evaluation of dementia. Blood investigations for reversible causes of dementia are taken. Psychologists administer a validated neuropsychological test battery. The non-memory domains tested are: Executive Function (Frontal Assessment Battery), Attention (Digit Span, Visual Memory Span, Auditory Detection), Language (Boston Naming Test, Verbal Fluency), and Visuomotor speed (Symbol Digit Modality Test, Digit Cancellation, Maze Task), Visuoconstruction (WMS-R Visual Reproduction Copy task, Clock Drawing, WAIS-R subtest of Block Design). The memory domains tested are: Verbal Memory (Word List Recall, Story Recall) and Visual Memory (Picture Recall, WMS-R Visual Reproduction). Magnetic Resonance Imaging (MRI) sequences used include Sagittal T1 FLAIR, Axial TSE T2, Axial T2*, Axial DWI, ADC maps, Coronal FLAIR, Coronal BRAVO (3DSPGR IR-Prepped) and MR Angiography. Dementia diagnosis is made at weekly consensus conference, according to DSM-IV. Aetiological diagnosis for Alzheimer's Disease follows the NINCDS-ADRDA criteria for AD, and the NINDS-AIREN criteria for Vascular Dementia. Dementia severity is assessed using the Clinical Dementia Rating Scale. The non-demented diagnoses include Cognitively Impaired Not Demented, or No Cognitive Impairment. Informed consent is obtained from all participants. The study has been approved by the Institutional Review Board. The study will provide new epidemiological data on the prevalence, spectrum and characteristics of dementia in a pan-Asian multi-ethnic cohort. This will facilitate healthcare resource allocation and design of clinical guidelines by various healthcare agencies that cater to the needs of the disabled elderly in Asia.
A Femoral Clamp to Reduce Soft Tissue Artifact: Accuracy and Reliability in Measuring Three-Dimensional Knee Kinematics During Gait (2019)

The accurate measurement of full six degrees-of-freedom (6DOFs) knee joint kinematics is prohibited by soft tissue artifact (STA), which remains the greatest source of error. The purpose of this study was to present and assess a new femoral clamp to reduce STA at the thigh. It was hypothesized that the device can preserve the natural knee joint kinematics pattern and outperform a conventional marker mounted rigid cluster during gait. Six healthy subjects were asked to walk barefoot on level ground with a cluster marker set (cluster gait) followed by a cluster-clamp-merged marker set (clamp gait) and their kinematics was measured using the cluster method in cluster gait and the cluster and clamp methods simultaneously in clamp gait. Two operators performed the gait measurement. A 6DOFs knee joint model was developed to enable comparison with the gold standard knee joint kinematics measured using a dual fluoroscopic imaging technique. One-dimensional (1D) paired t-tests were used to compare the knee joint kinematics waveforms between cluster gait and clamp gait. The accuracy was assessed in terms of the root-mean-square error (RMSE), coefficient of determination, and Bland-Altman plots. Interoperator reliability was assessed using the intraclass correlation coefficient (ICC). The result showed that the femoral clamp did not change the walking speed and knee joint kinematics waveforms. Additionally, clamp gait reduced the rotation and translation errors in the transverse plane and improved the interoperator reliability when compared to the rigid cluster method, suggesting a more accurate and reliable measurement of knee joint kinematics.
A Planar-Gate High-Conductivity IGBT (HiGT) With Hole-Barrier Layer (2007)

A high-conductivity insulated gate bipolar transistor (IGBT) (HiGT) with a double diffused MOS structure and an n-type hole-barrier layer surrounding a p-layer (planar HiGT) is presented. The hole-barrier layer prevents the holes from flowing into the p-layer and stores them in the n-layer. The planar HiGT provides a better tradeoff between collector-emitter saturation voltage [VcE(sat)] and turn-off loss than conventional IGBTs, regardless of the injection efficiency of the p-layer on the collector side, while it maintains a high blocking voltage by controlling the sheet carrier concentration of the hole-barrier layer. The planar HiGT has a tough short-circuit capability of more than 10 mus at 125degC, with a saturation current similar to that of conventional IGBTs.
An Overview of the VenusDB Active Multidatabase System. (1996)

VenusDB is a C++ embedded, forward-chaining rule language and compiler that includes linguistic elements and runtime support for accessing multiple databases across multiple platforms. Multidatabase access was a natural evolutionary step for Venus. Evaluation of Venus using an expert-database application revealed the need for explicit syntax for the expression of event conditions. Thus, VenusDB provides for both event-condition-action (ECA) rules typical of active-database systems and condition action rules typical of expert systems and expert-database systems. The Venus compiler is readily extended by virtue of an abstract interface, the AMI, that encapsulates the details of data access. Although middleware elements can be amorphous, the AMI forms a well defined interface for the encapsulation of databases and their integration with a forward-chaining inference engine.
New microwave gas detector using dielectric resonator based on a whispering-gallery-mode (2009)

This work describes a novel concept of gas sensor based on RF-transduction technique. The sensor uses a millimeter-wave planar dielectric resonator operating with Whispering-Gallery-Modes. The dielectric resonator incorporates a sensitive material (TiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> or SnO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> ) and two coplanar waveguides coupled to its input and output. In presence of gas, the dielectric permittivity of the resonator is modified and the resonant frequencies of some Whispering-Gallery-Modes are then significantly changed. The proof of concept is demonstrated here, through full wave electromagnetic simulations.
Human Breast Cancer Specimens: Diffraction-enhanced Imaging with Histologic Correlation—Improved Conspicuity of Lesion Detail Compared with Digital Radiography (2021)

Seven breast cancer specimens were examined with diffraction-enhanced imaging at 18 keV with a silicon crystal with use of the silicon 333 reflection in Bragg mode. Images were compared with digital radiographs of the specimen, and regions of increased detail were identified. Six of the seven cases (86%) showed enhanced visibility of surface spiculation that correlated with histopathologic information, including extension of tumor into surrounding tissue.
Metalation of arenechromium tricarbonyl complexes and electrophilic trapping of the complexed phenyllithium intermediate (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetalation of arenechromium tricarbonyl complexes and electrophilic trapping of the complexed phenyllithium intermediateM. F. Semmelhack, J. Bisaha, and M. CzarnyCite this: J. Am. Chem. Soc. 1979, 101, 3, 768–770Publication Date (Print):January 1, 1979Publication History Published online1 May 2002Published inissue 1 January 1979https://pubs.acs.org/doi/10.1021/ja00497a063https://doi.org/10.1021/ja00497a063research-articleACS PublicationsRequest reuse permissionsArticle Views401Altmetric-Citations118LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Figures 1-16 from Danger Signaling Protein HMGB1 Induces a Distinct Form of Cell Death Accompanied by Formation of Giant Mitochondria (2023)

Supplementary Figures 1-16 from Danger Signaling Protein HMGB1 Induces a Distinct Form of Cell Death Accompanied by Formation of Giant Mitochondria
Targeting CD22 in Childhood B-Precursor Acute Lymphoblastic Leukemia (Pre-B ALL): Pre-Clinical Studies and Phase I Trial of the Anti-CD22 Immunotoxin CAT-3888 (BL22). (2007)

Abstract Although most children with pre-B ALL are cured, treatment is associated with multiple toxicities and outcome after relapse is poor. New therapies are needed to overcome drug resistance and reduce non-specific toxicities of chemotherapy. We evaluated the B-lineage differentiation antigen CD22 and the anti-CD22 immunotoxin RFB4(dsFv)-PE38 (CAT-3888 or BL22) in childhood ALL. Methods: Blasts were obtained from children with pre-B ALL. Flow cytometry was used to determine CD22 expression and anti-CD22 antibody binding using the BD Quantibrite System. 72 hour in vitro protein synthesis cytotoxicity assays were conducted. Murine xenografts (human ALL cell line EU-1 into CB17 SCID mice) were treated with varying doses of CAT-3888. A pediatric Phase I trial of CAT-3888 was initiated. Results: All cases (n=69) were CD22 positive. Median CD22 site density (studied in 28 cases) was 4,099 sites/cell (range, 451 – 9,380). In vitro cytotoxicity to CAT-3888 was assessed in 43 cases and the median IC50 was 10 ng/ml. Murine xenografts treated with CAT-3888 had significant prolongation of leukemia free survival in a dose responsive fashion (p&lt;0.05). 21 subjects (18 ALL, 3 lymphoma; 3–22 years of age) were treated on a Phase I trial of CAT-3888 at doses of 10–40 mcg/kg QOD for 3–6 doses with cycles repeated every 21–28 days. Treatment was well tolerated and adverse events attributed to CAT-3888 were reversible. Pharmacokinetic parameters appeared to be influenced by disease burden consistent with rapid drug binding by CD22 positive blasts. All subjects were heavily pre-treated and had progressive high burden disease at the time of treatment. Transient clinical activity was observed in 17 of 21 subjects as evidenced by decreased peripheral blood blast count (8), decreased marrow infiltration (6), decreased extramedullary infiltration (3), increased platelet count (2), increased neutrophil count (1), increased reticulocyte count (1), improved PET scan (1), decreased tumor-associated pain (2), and/or peripheral blast count stabilization (5). A dose response was apparent with 6 of 12 (50%) achieving disease stabilization at or above 30 mcg/kg (vs. 0/9 at lower doses). Three subjects developed high-titer neutralizing antibodies, 1 of which had pre-existing low titer antibodies from prior pseudomonas infection. Conclusions: CD22 represents a relevant target for childhood pre-B ALL. All cases tested were CD22+ and most blasts were highly sensitive to CAT-3888 in vitro at concentrations below clinically achievable levels. CAT-3888 showed a dose response effect and prolonged leukemia free survival in murine ALL xenografts. CAT-3888 is well tolerated in children and activity has been seen in most subjects treated on the Phase I trial. A new higher affinity anti-CD22 immunotoxin (CAT-8015 or HA22) is in development.
MOBILE NETWORK MULTICAST SUPPORTED MAINTENANCE OF FREQUENCY STABILITY IN LOW INERTIA POWER GRIDS (2021)

In order to overcome decreasing grid inertia, Nordic transmission system operators introduced in 2020 a new reserve product, Fast Frequency Reserve (FFR). The FFR reserve should be capable of becoming activated within 0.7–1.3 seconds to compensate for the decreased inertia. This paper introduces and analyses a mobile (cellular) network multicast-based solution for providing FFR capabilities. A purpose-built measurement setup, including a real 4G and 5G packet core, base station and terminals, is developed to evaluate the response times. The FFR potential within one Distribution System Operator, KSS Verkko Oy, is analysed based on real grid data.