gebhart/patrepeval huggingface dataset:
Hands-on robotic unicompartmental knee replacement (2006)

We performed a prospective, randomised controlled trial of unicompartmental knee arthroplasty comparing the performance of the Acrobot system with conventional surgery. A total of 27 patients (28 knees) awaiting unicompartmental knee arthroplasty were randomly allocated to have the operation performed conventionally or with the assistance of the Acrobot. The primary outcome measurement was the angle of tibiofemoral alignment in the coronal plane, measured by CT. Other secondary parameters were evaluated and are reported. All of the Acrobot group had tibiofemoral alignment in the coronal plane within 2 degrees of the planned position, while only 40% of the conventional group achieved this level of accuracy. While the operations took longer, no adverse effects were noted, and there was a trend towards improvement in performance with increasing accuracy based on the Western Ontario and McMaster Universities Osteoarthritis Index and American Knee Society scores at six weeks and three months. The Acrobot device allows the surgeon to reproduce a pre-operative plan more reliably than is possible using conventional techniques which may have clinical advantages.
Physical Layer Security based on Time Reversal Technique for Urban Radio Channels (2018)

This work presents experimental characterization of feasibility of physical layer security based on time reversal technique for radio channels. The investigation is for outdoor urban microcellular radio channels for both scenarios of fixed and mobile receivers. The investigation is at frequency range of 2.4 GHz and bandwidth of measurement system is 100 MHz. A metric based on difference between strongest and 2nd strongest peak on power delay profile is proposed and presented as performance indicator.
Ecological and socio‐economic impacts of invasive water hyacinth (Eichhornia crassipes): a review (2009)

Summary 1. Water hyacinth ( Eichhornia crassipes ) is one of the world’s most invasive aquatic plants and is known to cause significant ecological and socio‐economic effects. 2. Water hyacinth can alter water clarity and decrease phytoplankton production, dissolved oxygen, nitrogen, phosphorous, heavy metals and concentrations of other contaminants. 3. The effects of water hyacinth on ecological communities appear to be largely nonlinear. Abundance and diversity of aquatic invertebrates generally increase in response to increased habitat heterogeneity and structural complexity provided by water hyacinth but decrease due to decreased phytoplankton (food) availability. 4. Effects of water hyacinth on fish are largely dependent on original community composition and food‐web structure. A more diverse and abundant epiphytic invertebrate community may increase fish abundance and diversity, but a decrease in phytoplankton may decrease dissolved oxygen concentrations and planktivorous fish abundance, subsequently affecting higher trophic levels. 5. Little is known about the effects of water hyacinth on waterbird communities; however, increases in macroinvertebrate and fish abundance and diversity suggest a potentially positive interaction with waterbirds when water hyacinth is at moderate density. 6. The socio‐economic effects of water hyacinth are dependent on the extent of the invasion, the uses of the impacted waterbody, control methods and the response to control efforts. Ecosystem‐level research programmes that simultaneously monitor the effects of water hyacinth on multiple trophic‐levels are needed to further our understanding of invasive species.
Design Methodology for High-Speed Permanent Magnet Synchronous Machines (2016)

In this paper, a design methodology for surface permanent magnet (PM) synchronous machines, with special application to the case of high-speed machines, will be presented. Following a discussion of the principle and assumptions inherent in the methodology, the analytical model used in the study will be presented. This model will then be implemented to solve the problem of maximizing the power-to-volume ratio from an analytical perspective. It will be shown how this formulation serves to establish design rules, in addition to setting criteria values for the selection of magnetic materials (i.e., silicon steel sheet versus a soft magnetic material). At last, the paper will present a data test bench made of two PM machines designed since the methodology presented herein.
Cytochrome oxidase models. 3. Spin coupling across imidazolate bridges in binuclear metalloporphyrin complexes of iron and copper (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCytochrome oxidase models. 3. Spin coupling across imidazolate bridges in binuclear metalloporphyrin complexes of iron and copperSteven E. Dessens, Connie L. Merrill, Robert J. Saxton, Robert L. Ilaria Jr., John W. Lindsey, and Lon J. WilsonCite this: J. Am. Chem. Soc. 1982, 104, 16, 4357–4361Publication Date (Print):August 1, 1982Publication History Published online1 May 2002Published inissue 1 August 1982https://pubs.acs.org/doi/10.1021/ja00380a008https://doi.org/10.1021/ja00380a008research-articleACS PublicationsRequest reuse permissionsArticle Views83Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Supplementary Material from Capivasertib, an AKT Kinase Inhibitor, as Monotherapy or in Combination with Fulvestrant in Patients with <i>AKT1</i><sup>E17K</sup>-Mutant, ER-Positive Metastatic Breast Cancer (2023)

&lt;p&gt;Supplementary tables&lt;/p&gt;
Safety, Tolerability, and Pharmacokinetics of Senaparib, a Novel PARP1/2 Inhibitor, in Chinese Patients With Advanced Solid Tumors: A Phase I Trial (2023)

NCT03508011.
Abstract B106: mTORC1 inhibition is required for sensitivity to PI3K p110α inhibitors in PIK3CA-mutant breast cancer. (2013)

Abstract Activating mutations of the PIK3CA gene occur frequently in breast cancer and inhibitors that are specific for PI3K p110α, such as BYL719, are being investigated in clinical trials. In a search for correlates of sensitivity to p110α inhibition among PIK3CA-mutant breast cancer cell lines, we observed that sensitivity to BYL719 (as assessed by cell proliferation) was associated with full inhibition of signaling through the TORC1 pathway. Conversely, cancer cells that were resistant to BYL719 had persistently active mTORC1 signaling, although Akt phosphorylation was inhibited. Similarly in patients, pS6 (residues 240/4) expression (a marker of mTORC1 signaling) was associated with tumor response to BYL719, and mTORC1 was found to be reactivated in tumors from patients whose disease progressed after treatment. In PIK3CA-mutant cancer cell lines with persistent mTORC1 signaling despite PI3K p110α blockade (that is, resistance), the addition of the allosteric mTORC1 inhibitor RAD001 to the cells along with BYL719 resulted in reversal of resistance in vitro and in vivo. Finally, we found that growth factors such as IGF1 and neuregulin1 can activate mTOR and mediate resistance to BYL719. Our findings suggest that simultaneous administration of mTORC1 inhibitors may enhance the clinical activity of p110α targeted drugs and delay the appearance of resistance. Citation Information: Mol Cancer Ther 2013;12(11 Suppl):B106. Citation Format: Moshe Elkabets, Sadhna Vora, Dejan Juric, Natasha Morse, Mari Mino-Kenudson, Taru Muranen, Jessica Tao, Ana Bosch Campos, Jordi Rodon, Yasir H. Ibrahim, Violeta Serra, Vanessa Rodrik-Outmezguine, Saswati Hazra, Sharat Singh, Phillip Kim, Cornelia Quadt, Liu Manway, Alan Huang, Neal Rosen, Jeffrey A. Engelman, Maurizio Scaltriti, José Baselga. mTORC1 inhibition is required for sensitivity to PI3K p110α inhibitors in PIK3CA-mutant breast cancer. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr B106.
ER and oxidative stresses are common mediators of apoptosis in both neurodegenerative and non-neurodegenerative lysosomal storage disorders and are alleviated by chemical chaperones (2007)

It is estimated that more than 40 different lysosomal storage disorders (LSDs) cumulatively affect one in 5000 live births, and in the majority of the LSDs, neurodegeneration is a prominent feature. Neuronal ceroid lipofuscinoses (NCLs), as a group, represent one of the most common (one in 12,500 births) neurodegenerative LSDs. The infantile NCL (INCL) is the most devastating neurodegenerative LSD, which is caused by inactivating mutations in the palmitoyl-protein thioesterase-1 (PPT1) gene. We previously reported that neuronal death by apoptosis in INCL, and in the PPT1-knockout (PPT1-KO) mice that mimic INCL, is at least in part caused by endoplasmic reticulum (ER) and oxidative stresses. In the present study, we sought to determine whether ER and oxidative stresses are unique manifestations of INCL or they are common to both neurodegenerative and non-neurodegenerative LSDs. Unexpectedly, we found that ER and oxidative stresses are common manifestations in cells from both neurodegenerative and non-neurodegenerative LSDs. Moreover, all LSD cells studied show extraordinary sensitivity to brefeldin-A-induced apoptosis, which suggests pre-existing ER stress conditions. Further, we uncovered that chemical disruption of lysosomal homeostasis in normal cells causes ER stress, suggesting a cross-talk between the lysosomes and the ER. Most importantly, we found that chemical chaperones that alleviate ER and oxidative stresses are also cytoprotective in all forms of LSDs studied. We propose that ER and oxidative stresses are common mediators of apoptosis in both neurodegenerative and non-neurodegenerative LSDs and suggest that the beneficial effects of chemical/pharmacological chaperones are exerted, at least in part, by alleviating these stress conditions.
Variable Velocity Fluidized Bed for Pyrolysis of Biomass (1978)

Current interest in converting solid hydrocarbon resources to liquid and gaseous products has spawned the development of many new technologies and the resurrection of some old technologies. One such technology is pyrolysis in a fluidized bed to produce gas that can be used as fuel or as a feedstock for petrochemical products. Processes utilizing fluidized bed technology are in varying stages of development for coal gasification, oil shale gasification and biomass gasification (1, 2, 3, 4, 5). Most of these processes employ steam and air or oxygen as the fluidizing medium. In the vicinity of the distributor, part of the solid is combusted to provide the heat to pyrolyze the remaining solid. The pyrolysis zone in the reactor is generally above and separate from the combustion zone. At the top of the reactor is an expanded disengaging section to prevent excessive solids entrainment in the produced gas. A fluidized bed
The Effect of Whey Isolate and Resistance Training on Strength, Body Composition, and Plasma Glutamine (2006)

Different dietary proteins affect whole body protein anabolism and accretion and therefore, have the potential to influence results obtained from resistance training. This study examined the effects of supplementation with two proteins, hydrolyzed whey isolate (WI) and casein (C), on strength, body composition, and plasma glutamine levels during a 10 wk, supervised resistance training program. In a double-blind protocol, 13 male, recreational bodybuilders supplemented their normal diet with either WI or C (1.5 gm/kg body wt/d) for the duration of the program. Strength was assessed by 1-RM in three exercises (barbell bench press, squat, and cable pull-down). Body composition was assessed by dual energy X-ray absorptiometry. Plasma glutamine levels were determined by the enzymatic method with spectrophotometric detection. All assessments occurred in the week before and the week following 10 wk of training. Plasma glutamine levels did not change in either supplement group following the intervention. The WI group achieved a significantly greater gain (P < 0.01) in lean mass than the C group (5.0 +/- 0.3 vs. 0.8 +/- 0.4 kg for WI and C, respectively) and a significant (P < 0.05) change in fat mass (-1.5 +/- 0.5 kg) compared to the C group (+0.2 +/- 0.3 kg). The WI group also achieved significantly greater (P < 0.05) improvements in strength compared to the C group in each assessment of strength. When the strength changes were expressed relative to body weight, the WI group still achieved significantly greater (P < 0.05) improvements in strength compared to the C group.
Monte Carlo Simulation of Device Variations and Mismatch in Analog Integrated Circuits (2006)

Device mismatches, the small random variations in the characteristics of identically designed devices, occur during the manufacturing of integrated circuits. These mismatches result in behavioral variations of analog and digital integrated circuits. Except for very small circuits, it is difficult to analytically predict the behavior of a circuit due to the combination of the mismatch errors of individual devices. The impact of these random parameter variations on circuit behavior can be studied with Monte Carlo simulation by analyzing a large set of circuit instantiations with randomly varied devices. In this paper, a set of Perl programs that automate the Monte Carlo simulation of circuits is presented. The tool generates a user specified number of modified netlists with randomly varied device characteristics. Each circuit device is modified according to a mismatch model for the device type. A user supplied parameters file controls the magnitude of variation for each device type and the tool automatically adjusts the parameter distributions of different device types and sizes. All netlists are simulated and their results are aggregated. These results reflect the tolerance of a circuit to device mismatch errors. Currently, the programs are optimized for the Spectre simulator from Cadence Systems, but the proposed approach can be adapted for other types of circuit simulators. The use of this tool is illustrated with the Monte Carlo analyses for the DC accuracy of a cascode current mirror, the random variation of the delays of a pair of inverter strings under transient operation, the matching of the oscillation frequencies of a set of ring oscillators, and the variation of the transfer characteristics of a fifth order elliptic low pass active filter including its common-mode rejection.
Analysis of Nonlinear Residual Echo Suppressors for Telecommunications (2005)

This paper analyzes the performance of nonlinear processors (NLP) that are commonly used for attenuating residual echoes in adaptive echo cancellers for voice communications. The NLP (or residual echo suppressor) implemented as a center clipper produces undesired nonlinear distortions. In this paper, the center-clipping effects are analyzed using Fourier analysis, which decomposes the clipped signal as the summation of a set of rectangular waves and a pulse-amplitude modulated signal. The theoretical analysis shows that the clipping of a sinusoidal signal produces extra odd harmonics, which can be reduced by using the uncompressed center clippers. The analysis results can be extended to speech signals since they can be modeled as the summation of multiple sinusoidal components.
First Multicenter Study of Modified Release Phosphatidylcholine “LT-02” in Ulcerative Colitis: A Randomized, Placebo-Controlled Trial in Mesalazine-Refractory Courses (2014)

The primary end point analysis showed a statistically significant improvement in disease activity during LT-02 treatment in comparison with placebo. The drug was found to be very safe.
Conceptual design and preliminary characterization of serial array system of high-resolution MEMS accelerometers with embedded optical detection (2005)

This paper introduces a technology for robust and low maintenance cost sensor network capable to detect accelerations below a micro-g in a wide frequency bandwidth (above 1,000 Hz). Sensor networks with such performance are critical for navigation, seismology, acoustic sensing, and for the health monitoring of civil structures. The approach is based on the fabrication of an array of high sensitivity accelerometers, each utilizing Fabry-Perot cavity with wavelength-dependent reflectivity to allow embedded optical detection and serialization. The unique feature of the approach is that no local power source is required for each individual sensor. Instead one global light source is used, providing an input optical signal which propagates through an optical fiber network from sensor-to-sensor. The information from each sensor is embedded onto the transmitted light as an intrinsic wavelength division multiplexed signal. This optical "rainbow" of data is then assessed providing real-time sensing information from each sensor node in the network. This paper introduces the Fabry-Perot based accelerometer and examines its critical features, including the effects of imperfections and resolution estimates. It then presents serialization techniques for the creation of systems of arrayed sensors and examines the effects of serialization on sensor response. Finally, a fabrication process is proposed to create test structures for the critical components of the device, which are dynamically characterized.
Determination of Tissue Plasminogen Activator (t-PA) Antigen in Seminal Plasma by Modified Enzyme-Linked Immunosorbant Assay (ELISA) (2009)

The determination of tissue plasminogen activator (t-PA) antigen in semen by a new immunoenzymatic method was done in 152 men without genito urinary pathology. The seminal value is one hundred higher than the blood value with a log normal distribution. These levels are not influenced by freezing temperature, by the sequences freezing-thawing, by centrifugation. From split ejaculates a correlation has been established between t-PA antigen and zinc and not with fructose. These results indicate the major prostatic origin of the t-PA antigen.
Characterization of CF4 Plasma-Treated Indium–Tin-Oxide Surfaces Used in Organic Light-Emitting Diodes by X-ray Photoemission Spectroscopy (2007)

The CF4 plasma treatment of indium–tin-oxide (ITO) greatly improves the performance of organic light-emitting diodes (OLEDs). The effects of plasma treatment on the chemical composition change and device performance were investigated by X-ray photoemission spectroscopy (XPS). The present results suggest that fluorine directly bonded to indium or tin on the ITO surface and markedly enhanced device performance.
DEPLOYING JOINT BEAM HOPPING AND PRECODING IN MULTIBEAM SATELLITE NETWORKS WITH TIME VARIANT TRAFFIC (2018)

This paper studies the application of Beam Hopping (BH) as a key enabler to provide high level of flexibility to manage scarce on-board resources, particularly power, based on the irregular and time variant traffic requests/demands distributed within the coverage of a satellite multibeam system. However, while high throughput full frequency reuse pattern is employed among beams, the performance of BH is significantly degraded due to the generated inter-beam interference, and applying precoding is essential. In this context, we propose Joint Precoding and BH (J-PBH) in a multibeam system. The proposed J-PBH has the following functionality: serving beams follows an illumination pattern where at consecutive time instants high-demand beams are served more often than low-demand beams. Then, a Zero Forcing precoding is employed aiming at equalizing inter-beam interference. Consequently, the proposed J-PBH flexibly manage on-board power resources between high- and low-demand beams. Numerical simulations are presented which validate the proposed J-PBH benefits.
Ultra-wideband ladder filters using zero-th shear mode plate wave in ultrathin LiNbO3 plate with apodized interdigital transducers (2016)

Abstract There are two kinds of plate waves propagating in a thin plate, Lamb and shear horizontal (SH) waves. The former has a velocity higher than 15,000 m/s when the plate is very thin. On the contrary, 0th SH (SH 0 ) mode plate wave in an ultrathin LiNbO 3 plate has an electro-mechanical coupling factor larger than 50%. Authors fabricated an ultra-wideband T-type ladder filter with a relative bandwidth (BW) of 41% using the SH 0 mode plate wave. Although the BW of the filter fully covers the digital TV band in Japan, it does not have sufficient margin at the lower and higher end of BW. Besides, periodic small ripples due to transverse mode in pass-band of the filter were observed. In this study π-type ladder filters were fabricated by changing the pitch ratio of interdigital transducer (IDT) of parallel and series arm resonators (PR (IDT) ) to control the BW, and by apodizing IDTs to improve the periodic small ripples due to transverse mode. Ultra-wideband filters without periodic small transverse mode with ultrawide bandwidth from 41 to 49% were fabricated. The BWs fully cover ultrawide digital television bands in Japan and U.S.A. These filters with an ultrawide BW and a steep characteristic show the possibility to be applied to a reported cognitive radio system and other communication systems requiring an ultrawide BW.
Recent Advances in Organosiloxane Copolymers (1988)

Organosiloxane copolymers have been of great interest over the past several years due to the somewhat unique characteristics imparted by the siloxane blocks. The excellent UV and oxidative resistance of these structures together with their outstanding thermal stability and wide temperature use range make them candidates as modifiers for a multitude of applications. Organosiloxane materials have now been prepared which demonstrate a variety of interesting properties such as atomic oxygen resistance, biocompatibility, high gas permeabilities, and hydrophobic surfaces. In this paper, the synthesis and properties of functional polysiloxane oligomers which are the precursors for the copolymers are discussed. Additionally, a summary and review of the preparation and characteristics of the organosiloxane copolymers is given.