gebhart/patrepeval huggingface dataset:
Outcome of partial reconstruction of multiple hepatic arteries in pediatric living donor liver transplantation using left liver grafts (2016)

Partial liver grafts used in living donor liver transplantation (LDLT) may have multiple hepatic artery (HA) stumps. This study was designed to validate the safety of partial reconstruction of multiple HAs in pediatric LDLT cases. From January 2000 to June 2014, 136 pediatric LDLT recipients were categorized into three groups: single HA group (Group 1, n = 74), multiple HAs with total reconstruction group (Group 2, n = 23), and multiple HAs with partial reconstruction group (Group 3, n = 39). Partial reconstruction was performed only when there was pulsatile back-bleeding after larger HA reconstruction and sufficient intrahepatic arterial flow was confirmed by Doppler ultrasound (DUS). There was no significant difference in biliary complication rate, artery complication rate, patient survival, and graft survival among these groups. Risk factor analysis revealed that the presence of multiple HAs and partial reconstruction of multiple HAs were not risk factors of biliary anastomosis stricture. In conclusion, partial reconstruction of HAs during pediatric LDLT using a left liver graft with multiple HA stumps does not increase the risk of biliary anastomosis stricture or affect graft survival when intrahepatic arterial communication is confirmed by pulsatile back-bleeding and DUS.
Persister Cells Resuscitate Using Membrane Sensors that Activate Chemotaxis, Lower cAMP Levels, and Revive Ribosomes (2018)

ABSTRACT Persistence, the stress-tolerant state, is arguably the most vital phenotype since nearly all cells experience nutrient stress, which causes a sub-population to become dormant. However, how persister cells wake to reconstitute infections is not understood well. Here, using single-cell observations, we determined that Escherichia coli persister cells resuscitate primarily when presented with specific carbon sources, rather than spontaneously. In addition, we found that the mechanism of persister cell waking is through sensing nutrients by chemotaxis and phosphotransferase membrane proteins. Furthermore, nutrient transport reduces the level of secondary messenger cAMP through enzyme IIA; this reduction in cAMP levels leads to ribosome resuscitation and rescue. Resuscitating cells also immediately commence chemotaxis toward nutrients, although flagellar motion is not required for waking. Hence, persister cells wake by perceiving nutrients via membrane receptors which relay the signal to ribosomes via the secondary messenger cAMP, and persisters wake and utilize chemotaxis to acquire nutrients.
Oral lipoic acid as a treatment for acute optic neuritis: A blinded, placebo-controlled randomized trial (P6.388) (2017)

To determine whether LA is neuroprotective in AON.
Energy-efficient Trajectory Design for UAV-enabled Wireless Communications with Latency Constraints (2019)

This paper studies a new energy-efficient unmanned aerial vehicle (UAV)-enabled wireless communications, where the UAV acts as a flying base station (BS) to serve the ground users (GUs) within some predetermined latency limitations, e.g., requested timeout (RT). Our goal is to design the UAV trajectory to minimize the total energy consumption while satisfying the RT requirement from every GU, which is accomplished via two consecutive subproblems: traveling time minimization and energy minimization problems. Firstly, we propose two exhaustive search and heuristic algorithms based on the traveling salesman problem with time window (TSPTW) in order to minimize the UAV's traveling time without violating the GUs' RT requirements. While the exhaustive algorithm achieves the best performance at a high computation cost, the heuristic algorithm achieves a trade-off between the performance and complexity. Secondly, we minimize the total energy consumption, for a given trajectory, via a joint optimization of the UAV's velocity along subsequent hops. Finally, numerical results are presented to demonstrate the effectiveness of our proposed algorithms. In particular, it is shown that the proposed solutions outperform the reference in terms of both energy consumption and outage performance.
Differential human gut microbiome assemblages during soil-transmitted helminth infections in Indonesia and Liberia (2018)

For the first time, we identify specific members of the gut microbiome that discriminate between moderately/heavily STH-infected and non-infected states across very diverse geographical regions using two different statistical methods. We also identify microbiome-encoded biological functions associated with the STH infections, which are associated potentially with STH survival strategies, and changes in the host environment. These results provide a novel insight of the cross-kingdom interactions in the human gut ecosystem by unlocking the microbiome assemblages at taxonomic, genetic, and functional levels so that advances towards key mechanistic studies can be made.
Use of a “Catalytic” Cosolvent, N,N‐Dimethyl Octanamide, Allows the Flow Synthesis of Imatinib with no Solvent Switch (2016)

Abstract A general, efficient method for C−N cross‐coupling has been developed using N , N ‐dimethyloctanamide as a catalytic cosolvent for biphasic continuous‐flow applications. The described method was used to generate a variety of biarylamines and was integrated into a two‐step sequence which converted phenols into biarylamines via either triflates or tosylates. Additionally, the method was applied to a three‐step synthesis of imatinib, the API of Gleevec, in good yield without the need of solvent switches.
Deletion of 3(p14p23) in Secondary Erythroleukemia Arising in Long-Term Survivors of Small Cell Lung Cancer (1988)

Cytogenetic studies were done on the leukemia cells of two patients with small cell lung cancer (SCLC) who developed erythroleukemia (acute nonlymphocytic leukemia, French-American-British M6) after combined modality chemotherapy and radiotherapy for their lung cancer. Surprisingly, both erythroleukemias exhibited the del(3)(p14p23) predominantly found in SCLC. In four other patients who had secondary erythroleukemias associated with other cancers, no deletions of 3p were found. These findings could be accounted for by one of three possible mechanisms: (a) an inherited recessive gene (anti-oncogene or tumor suppressor gene) in this region of 3p was uncovered by the combined modality therapy, (b) an inherited predisposition to damage of both chromosomes at 3p14 leads to SCLC and erythroleukemia after exposure to carcinogens and/or chemotherapy-radiotherapy, or (c) the finding of lineage specificity for the 3p deletion with the presence of the 3p deletion in SCLC and erythroleukemia suggests a common bone marrow precursor.
Ceramic-in-Polymer Hybrid Electrolytes with Enhanced Electrochemical Performance (2022)

Polymer electrolytes are attractive candidates to boost the application of rechargeable lithium metal batteries. Single-ion conducting polymers may reduce polarization and lithium dendrite growth, though these materials could be mechanically overly rigid, thus requiring ion mobilizers such as organic solvents to foster transport of Li ions. An inhomogeneous mobilizer distribution and occurrence of preferential Li transport pathways eventually yield favored spots for Li plating, thereby imposing additional mechanical stress and even premature cell short circuits. In this work, we explored ceramic-in-polymer hybrid electrolytes consisting of polymer blends of single-ion conducting polymer and PVdF-HFP, including EC/PC as swelling agents and silane-functionalized LATP particles. The hybrid electrolyte features an oxide-rich layer that notably stabilizes the interphase toward Li metal, enabling single-side lithium deposition for over 700 h at a current density of 0.1 mA cm<sup>-2</sup>. The incorporated oxide particles significantly reduce the natural solvent uptake from 140 to 38 wt % despite maintaining reasonably high ionic conductivities. Its electrochemical performance was evaluated in LiNi<sub>0.6</sub>Co<sub>0.2</sub>Mn<sub>0.2</sub>O<sub>2</sub> (NMC622)||Li metal cells, exhibiting impressive capacity retention over 300 cycles. Notably, very thin LiNbO<sub>3</sub> coating of the cathode material further boosts the cycling stability, resulting in an overall capacity retention of 78% over more than 600 cycles, clearly highlighting the potential of hybrid electrolyte concepts.
GaN-based MIS-HEMTs with Al2O3 dielectric deposited by low-cost and environmental-friendly mist-CVD technique (2021)

Abstract We report on the fabrication and characterization of AlGaN/GaN metal-insulator-semiconductor (MIS) capacitors and high-electron-mobility transistors (MIS-HEMTs) using a 5 nm thick Al 2 O 3 dielectric deposited by cost-effective and environmental-friendly mist chemical vapor deposition (mist-CVD) technique. Practically hysteresis-free capacitance–voltage profiles were obtained from the fabricated two-terminal MIS-capacitors indicating high quality of the mist-Al 2 O 3 /AlGaN interface. Compared with reference Schottky-gate HEMTs, mist MIS-HEMTs exhibited much improved performance including higher drain current on-to-off ratio, much lower gate leakage current in both forward and reverse directions and lower subthreshold swing. These results demonstrate the potential and viability of non-vacuum mist-CVD Al 2 O 3 in the development of high-performance GaN-based MIS-HEMTs.
Lateral capillary forces between colloidal particles incorporated in liquid films or lipid bilayers (2007)

The lateral capillary force appears between particles protruding from a liquid film and its physical origin is the overlap of the menisci formed around the separate particles. In turn, the size and shape of a separate meniscus is determined by the wetting properties of the particle surface, i.e., by the intermolecular forces. Therefore, the lateral capillary interaction is operative between particles of size from 1 mm down to 10 nm. Here, we first report data for direct measurement of capillary forces between particles of millimeter and submillimeter size by means of a torsional balance. Next, we present theoretical calculationsd of the capillary interaction between much smaller particles confined in spherical thin liquid films (vesicles, liposomes, etc.). As a result, we obtain a strong interparticle attraction, which can bring about aggregation and ordering of the particles in consonance with the experimental observations.
Timing Definition Language (TDL) Modeling in Ptolemy II (2008)

This work presents a modeling and simulation platform for embedded control systems where real-time requirements are explicitly specified in the system model by using the Timing Definition Language (TDL). TDL employs the Logical Execution Time (LET) abstraction to specify platformindependent execution times of periodic time-triggered computational tasks, with the main aim of achieving time and value determinism of composable embedded software. For a certain execution platform, this aim is attained if the software components can be suitably scheduled for execution so that the LET specifications are satisfied. In general, an embedded control system contains also concurrent computations triggered by environment conditions (dynamic events), which share the same execution platform. This makes static schedulability analysis for the LET-based part hard to achieve. Thus, a simulation platform is needed to investigate the interaction between time-triggered components and components triggered by dynamic events. We have implemented such a simulation platform by extending the Ptolemy II framework, thus leveraging models of computation that are already available in Ptolemy II, such as the modal model and the discrete event domains.
Synthesis of Diamondoids by Supercritical Xenon Discharge Plasma (2011)

Diamondoids were synthesized by dielectric barrier discharges in supercritical xenon containing dissolved adamantane, which served as a precursor. The synthesis of diamantane was confirmed by gas chromatography mass spectrometry measurements, in addition to energy-dispersive X-ray spectroscopy and micro-Raman spectroscopy measurements. Moreover, the possible synthesis of two higher-order diamondoids, pentamantane and decamantane, with molecular weights of 330 and 456, respectively, is indicated from the selective ion monitoring mode. The largest production yield was obtained in the vicinity of the critical point.
Speech-based human-robot interaction robust to acoustic reflections in real environment (2014)

Acoustic reflection inside an enclosed environment is detrimental to human-robot interaction. Reflection may manifest as phantom sources emanating from unknown directions. In effect, a single speaker may falsely manifest as multiple speakers to the robot audition system, impeding the robot's ability to correctly associate the speech command to the actual speaker. Moreover, speech reflection smears the original speech signal due to reverberation. This degrades speech recognition and understanding performance. Conventional robot audition schemes that rely purely on acoustics and spatial information are very sensitive to acoustic reflection which ultimately leads to the failure in human-robot interaction. We propose a method for human-robot interaction robust to the effect of acoustic reflection. First, visual information is utilized and head tracking scheme is employed to reinforce the acoustic information with the visual presence of a prospect user. Second, we employ a model-based sound event identification scheme and scrutinize whether the acoustic information is likely to be speech or non-speech. Using all the information we have gathered, we create a simple rule construct to effectively discriminate the original source (actual speaker) from phantom sources (reflection). Consequently, the corresponding source identified as phantom (reflection) is used to estimate the unwanted smearing for effective suppression via speech enhancement. Experiments are conducted in human-robot interaction setting in which the proposed method outperforms the conventional method.
Supplementary Tables from AR Expression in Breast Cancer CTCs Associates with Bone Metastases (2023)

&lt;p&gt;Supplementary Table S1: Patients and clinical information. Supplementary Table S2: Genes used to determine the AR signature.&lt;/p&gt;
Supplementary Figure 1 from ICOS Is an Indicator of T-cell–Mediated Response to Cancer Immunotherapy (2023)

&lt;p&gt;Figure S1: Stability of 89Zr-DFO-ICOS mAb in PBS and serum&lt;/p&gt;
Multipole shimming of permanent magnets using harmonic corrector rings (2007)

Shimming systems are required to provide sufficient field homogeneity for high resolution nuclear magnetic resonance (NMR). In certain specialized applications, such as rotating-field NMR and mobile ex situ NMR, permanent magnet-based shimming systems can provide considerable advantages. We present a simple two-dimensional shimming method based on harmonic corrector rings which can provide arbitrary multipole order shimming corrections. Results demonstrate, for example, that quadrupolar order shimming improves the linewidth by up to an order of magnitude. An additional order of magnitude reduction is in principle achievable by utilizing this shimming method for z-gradient correction and higher order xy gradients.
Compact semiconductor-based chirped-pulse amplification laser system (2004)

A compact chirped pulse amplification laser was developed based on fiber pigtailed semiconductor gain elements and chirped fiber Bragg gratings. The shoebox sized system produced 10 pJ, 1 MHz pulsetrains, amplified to 7 rJ with inclusion of EDFA.
Magnetic resonance imaging demonstrates incomplete myelination in 18q- syndrome (1997)

Magnetic resonance imaging (MRI) and MRI relaxometry were used to investigate disturbed brain myelination in 18q- syndrome, a disorder characterized by mental retardation, dysmorphic features, and growth failure. T1-weighted and dual spin-echo T2-weighted MR images were obtained, and T1 and T2 parametric image maps were created for 20 patients and 12 controls. MRI demonstrated abnormal brain white matter in all patients. White matter T1 and T2 relaxation times were significantly prolonged in patients compared to controls at all ages studied, suggesting incomplete myelination. Chromosome analysis using fluorescence in situ hybridization techniques showed that all patients with abnormal MRI scans and prolonged white matter T1 and T2 relaxation times were missing one copy of the myelin basic protein (MBP) gene. The one patient with normal-appearing white matter and normal white matter T1 and T2 relaxation times possessed two copies of the MBP gene. MRI and molecular genetic data suggest that incomplete cerebral myelination in 18q- is associated with haploinsufficiency of the gene for MBP.
Transcriptional, epigenetic and retroviral signatures identify regulatory regions involved in hematopoietic lineage commitment (2016)

Genome-wide approaches allow investigating the molecular circuitry wiring the genetic and epigenetic programs of human somatic stem cells. Hematopoietic stem/progenitor cells (HSPC) give rise to the different blood cell types; however, the molecular basis of human hematopoietic lineage commitment is poorly characterized. Here, we define the transcriptional and epigenetic profile of human HSPC and early myeloid and erythroid progenitors by a combination of Cap Analysis of Gene Expression (CAGE), ChIP-seq and Moloney leukemia virus (MLV) integration site mapping. Most promoters and transcripts were shared by HSPC and committed progenitors, while enhancers and super-enhancers consistently changed upon differentiation, indicating that lineage commitment is essentially regulated by enhancer elements. A significant fraction of CAGE promoters differentially expressed upon commitment were novel, harbored a chromatin enhancer signature, and may identify promoters and transcribed enhancers driving cell commitment. MLV-targeted genomic regions co-mapped with cell-specific active enhancers and super-enhancers. Expression analyses, together with an enhancer functional assay, indicate that MLV integration can be used to identify bona fide developmentally regulated enhancers. Overall, this study provides an overview of transcriptional and epigenetic changes associated to HSPC lineage commitment, and a novel signature for regulatory elements involved in cell identity.
Risikofaktoren für die Notwendigkeit einer invasiven Beatmung nach LISA-Verfahren (2023)

Ein weniger invasives Beatmungskonzept einschließlich Surfactantgabe via LISA-Verfahren begünstigt das Outcome bei Frühgeborenen < 29 Schwangerschaftswochen (SSW). Für eine zukünftig möglichst individualisierte Versorgung ist die Identifikation von Risikofaktoren für ein "LISA-Versagen", d.h. die Notwendigkeit der invasiven Beatmung innerhalb der ersten 72 Lebensstunden, sehr bedeutsam.
Long term herpes simplex virus type 1 infection of nerve growth factor-treated PC12 cells (1994)

The behaviour of herpes simplex virus type 1 (HSV-1) strain 17 in tissue cultures of PC12 cells treated with nerve growth factor (NGF) was studied. PC12 cells respond to NGF by ceasing to proliferate and extending long neurites. After differentiation with NGF, cultures were infected with HSV-1 and maintained in the presence of the hormone for several weeks. These long-term infected cultures were tested for HSV DNA, transcripts and the ability to produce virus, before and after NGF removal. Before NGF removal, the cultures were characterized by little or no virus production and the presence of HSV-1 DNA in a predominantly endless form. In situ analysis of long-term infected cultures revealed latency-associated transcript expression in only a portion of the cells. However, as shown by an infectious centre assay, virus was present in almost all cells in the population. Moreover, removal of NGF from long-term cultures resulted in the appearance of significantly increased amounts of virus in the media. The degree to which this system resembles HSV latency in vivo is discussed.
Single point incremental forming of bilayer sheets made of two different thermoplastics (2018)

ABSTRACT A novel configuration of bilayer composite sheets containing different polymers is described and used for the first time in the single point incremental forming (SPIF) process. These bilayer sheets made of polypropylene (PP) and Santoprene are fabricated by hot welding, and shaped with cone‐like geometry by SPIF. The bilayer configuration is such that only one of the containing polymers is in contact with the forming tool. During the SPIF processing, the bilayer sheets show a noticeable difference in the mechanical response, depending mainly on the polymer that is not in contact with the forming tool, which is related to a lower polymer softening. The performance of the bilayer sheets is compared against the neat polymers and a blend of these with a mass ratio of 1:1. The observed effect is introduced as a dual effect of properties that brings together in a single composite sheet, properties for a better performance in SPIF and wider functionality of the fabricated parts, evidenced by a lower material softening and higher mechanical strength, in comparison with the two individual polymers, and even better than the blend of both. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 47093.
On the feasibility of full-duplex relaying in the presence of loop interference (2009)

We consider a two-hop infrastructure-based relay link with three transmit power allocation methods. Both amplify-and-forward and decode-and-forward protocols are studied. Fundamentally, a relay can operate either in a full-duplex or in a half-duplex mode. The performance in full-duplex relaying is degraded due to loop interference from the relay output to the relay input. On the other hand, the half-duplex mode eliminates the loop interference, but this reduces the end-to-end rate. In this paper, we study the feasibility of the full-duplex mode in terms of end-to-end capacity. In particular, we evaluate break-even loop interference levels, below which the full-duplex mode outperforms the half-duplex mode. The analysis shows that the full-duplex mode is feasible in the presence of reasonably high loop interference power and can offer higher capacity than the half-duplex mode.
Conditional Radioresistance of tet-Inducible Manganese Superoxide Dismutase Bone Marrow Stromal Cell Lines (2013)

Mitochondrial targeted manganese superoxide dismutase is a major antioxidant enzyme, the levels of which modulate the response of cells, tissues and organs to ionizing irradiation. We developed a Tet-regulated MnSOD mouse (MnSOD(tet)) to examine the detailed relationship between cellular MnSOD concentration and radioresistance and carried out in vitro studies using bone marrow culture derived stromal cell lines (mesenchymal stem cells). Homozygous MnSOD(tet/tet) cells had low levels of MnSOD, reduced viability and proliferation, increased radiosensitivity, elevated overall antioxidant stores, and defects in cell proliferation and DNA strand-break repair. Doxycycline (doxy) treatment of MnSOD(tet/tet) cells increased MnSOD levels and radioresistance from ñ of 2.79 ± 1.04 to 8.69 ± 1.09 (P = 0.0060) and normalized other biologic parameters. In contrast, MnSOD(tet/tet) cells showed minimal difference in baseline and radiation induced mRNA and protein levels of TGF-β, Nrf2 and NF-κB and radiation induced cell cycle arrest was not dependent upon MnSOD level. These novel MnSOD(tet/tet) mouse derived cells should be valuable for elucidating several parameters of the oxidative stress response to ionizing radiation.