gebhart/patrepeval huggingface dataset:
Omalizumab for Aspirin Hypersensitivity and Leukotriene Overproduction in Aspirin-exacerbated Respiratory Disease. A Randomized Controlled Trial (2020)

<b>Rationale:</b> Aspirin-exacerbated respiratory disease is characterized by severe asthma, nonsteroidal antiinflammatory drug hypersensitivity, nasal polyposis, and leukotriene overproduction. Systemic corticosteroid therapy does not completely suppress lifelong aspirin hypersensitivity. Omalizumab efficacy against aspirin-exacerbated respiratory disease has not been investigated in a randomized manner.<b>Objectives:</b> To evaluate omalizumab efficacy against aspirin hypersensitivity, leukotriene E<sub>4</sub> overproduction, and symptoms during an oral aspirin challenge in patients with aspirin-exacerbated respiratory disease using a randomized design.<b>Methods:</b> We performed a double-blind, randomized, crossover, placebo-controlled, single-center study at Sagamihara National Hospital between August 2015 and December 2016. Atopic patients (20-79 yr old) with aspirin-exacerbated respiratory disease diagnosed by systemic aspirin challenge were randomized (1:1) to a 3-month treatment with omalizumab or placebo, followed by a >18-week washout period (crossover design). The primary endpoint was the difference in area under logarithm level of urinary leukotriene E<sub>4</sub> concentration versus time curve in the intent-to-treat population during an oral aspirin challenge.<b>Measurements and Main Results:</b> Sixteen patients completed the study and were included in the analysis. The area under the logarithm level of urinary leukotriene E<sub>4</sub> concentration versus time curve during an oral aspirin challenge was significantly lower in the omalizumab phase (median [interquartile range], 51.1 [44.5-59.8]) than in the placebo phase (80.8 [interquartile range, 65.4-87.8]) (<i>P</i> < 0.001). Ten of 16 patients (62.5%) developed oral aspirin tolerance up to cumulative doses of 930 mg in the omalizumab phase (<i>P</i> < 0.001).<b>Conclusions:</b> Omalizumab treatment inhibited urinary leukotriene E<sub>4</sub> overproduction and upper/lower respiratory tract symptoms during an oral aspirin challenge, resulting in aspirin tolerance in 62.5% of the patients with aspirin-exacerbated respiratory disease.
Killer Dendritic Cells and their Potential Role in Immunotherapy (2008)

Tumor immunosurveillance is mediated by innate and adaptive components of cellular immunity. A complex network of cellular interactions is needed to elicit protective antitumoral CD4+and CD8+T cell responses. Thereby dendritic cells (DCs) play a central role as professional antigen presenting cells (APCs) that take up antigens, process, and present them to prime naïve T cells. Recognition and lysis of tumor cells has been attributed to innate effectors such as natural killer (NK), NKT and gammadeltaT cells. Recently, novel subsets of cytotoxic DCs, called "killer DCs" (KDCs), have been reported in rodents and humans. Killer dendritic cells could directly link innate and adaptive immunity. This review aims at comparing the different KDC populations, their phenotypes, killer function, and their potential application for anticancer immunotherapy.
Activation of the human immunodeficiency virus type 2 enhancer is dependent on purine box and kappa B regulatory elements (1992)

Human immunodeficiency virus type 2 (HIV-2) displays several features which distinguish it from HIV-1. Among the differences in these two viruses are the responses of their enhancer regions to T-cell activation. For example, stimulation of HIV-1 transcription is largely dependent on two kappa B regulatory elements. In contrast, the HIV-2 enhancer has a single kappa B site and contains additional cis-acting sequences responsive to induction. One of these sites, previously termed CD3R, is a purine-rich site, also called PuB1, which is responsive to stimulation of the CD3 component of the T-cell receptor complex and binds Elf-1, a member of the ets proto-oncogene family. In this report, we examine the interaction of the PuB1 site with other sites in the HIV-2 enhancer. We demonstrate that the PuB1 site confers responsiveness to T-cell activators only in cooperation with additional enhancer elements. Induction of the HIV-2 enhancer is dependent on at least two other cis-acting regulatory elements in addition to PuB1 and kappa B. One of these elements is another purine-rich site (PuB2), which also binds recombinant Elf-1. An adjacent region, proximal to the PuB2 ets (pets) site, shows protection in DNase footprinting experiments with extracts from Jurkat T cells. Mutation of either the kappa B, PuB1, PuB2, or pets site significantly reduces the response of the HIV-2 enhancer to T-cell stimulation, an effect which is mediated at the RNA level. Therefore, activation of the HIV-2 enhancer is dependent on at least four cis-acting elements, only one of which is found in HIV-1, which act in synergy with one another. Despite their sequence similarity, the organization and function of the HIV-2 enhancer have diverged considerably from those of HIV-1.
MASEA : Marche Assistée par Stimulation Électrique Adaptative (2010)

International audience
Statistical beam information for mmW positioning (2020)

This paper proposes to collect statistical information of beam usage from multiple base stations for user localization at mmW carrier frequencies. This information is then used to construct multidimensional histograms that capture the correlations between good beam directions from multiple base stations. The histograms can be used to reduce the complexity of the multiple beam searches required for mmW positioning. Simulation results suggest that the multidimensional histograms are sparse, with only a few dominating beam directions. In light of this insight, methods are proposed to reduce the time needed to locate a mobile terminal when the observed time difference of arrival method is used for positioning.
Spatial-Wideband Effect in Massive MIMO with Application in mmWave Systems (2018)

Massive MIMO, especially in the millimeter- wave frequency bands, has been recognized as a promising technique to enhance spectrum and energy efficiency, as well as network coverage for wireless communications. Most research in massive MIMO just uses the extended conventional MIMO channel model by directly assuming that the channel dimensionality becomes large. With massive numbers of antennas, however, there exists a non-negligible propagation delay across the large array aperture, which then causes a transmitted symbol to reach different antennas with different delays, thereby rendering conventional MIMO channel models inapplicable. Such a phenomenon is known as the spatial-wideband effect in the areas of array signal processing and radar signal processing, and introduces the beam squint effect in beamforming. However, the spatial-wideband effect and the related beam squint issue are seldom studied in massive MIMO communications. To design a practical massive MIMO system, it is important to understand when the spatial-wideband effect appears and how it affects signal transmission, how the spatial-wideband effect interacts with the frequency-wideband effect (frequency selectivity), especially for multi-carrier modulations such as orthogonal frequency- division multiplexing (OFDM), and how we should re-design the transceiver. In this article we suggest a new massive MIMO channel model that embraces both the spatial- and frequency- wideband effects, and discuss these issues.
ONTOGENESIS OF DOPAMINERGIC‐CHOLINERGIC INTERACTIONS IN THE RAT STRIATUM: A NEUROCHEMICAL STUDY (1976)

Abstract— In the striatum of the newborn rat, the activity of tyrosine hydroxylase, the concentration of dopamine and the activity of the synaptosomal high‐affinity uptake process for dopamine is 10% of that of the adult; there is a linear and closely associated increase in all three parameters during maturation, achieving 75% of adult levels by 4 weeks after birth. In contrast, the specific activity of choline acetyltransferase exhibits a more delayed developmental rise commencing 1 week after birth; the concentration of acetylcholine is disproportionately high in the neonatal striatum and precedes the developmental increase in the activity of choline acetyltransferase. At birth, the specific activity of dopamine‐sensitive adenylate cyclase is 20% of that of the adult striatum and achieves adult activity by 4 weeks after birth. Pretreatment with the neuroleptic, fluphenazinc. does not reduce the striatal content of acetylcholine until 8 days after birth. It is postulated that dopaminergic influences on cholinergic neuronal activity appear when the cholinergic neurons in the striatum cease dividing and start differentiating.
Correlation of Cholinergic Functional Stimulation by Exogenous NGF with Aged Rat Behavior (1991)

The neurotrophic protein known as nerve growth factor (NGF, Levi-Montalcini, 1987) has recently been shown to have profound effects on the survival and transmitter function of central cholinergic neurons in both the basal forebrain and striatum of neonatal rodents, and adult rodents and primates (Whittemore and Sciger, 1987; Williams et al., 1989, Tuszynski et al., 1990, and Koliatsos, this volume). From such animal research has evolved the clinical hypothesis that NGF therapy would ameliorate the behavioral impairments associated with age-related cholinergic dysfunction, particularly Alzheimer’s disease (AD, Hefti and Weiner, 1986; Phelps et al., 1989). Still, many questions remain concerning the mechanisms of acetylcholine (ACh) homeostasis in the brain, and the specific behaviors mediated by central cholinergic pathways that are affected by Alzheimer’s disease. Also unknown is the full extent of NGF’s effects on both cholinergic and non-cholinergic neuronal systems.
Neither azeotropic drying, nor base nor other additives: a minimalist approach to 18F-labeling (2014)

A novel, efficient, time-saving and reliable radiolabeling procedure via nucleophilic substitution with [(18)F]fluoride is described. Different radiolabeled aliphatic and aromatic compounds were prepared in high radiochemical yields simply by heating of quaternary anilinium, diaryliodonium and triarylsulfonium [(18)F]fluorides in suitable solvents. The latter were obtained via direct elution of (18)F(-) from an anion exchange resin with alcoholic solutions of onium precursors. Neither azeotropic evaporation of water, nor a base, nor any other additives like cryptands or crown ethers were necessary. Due to its simplicity this method should be highly suitable for automated radiosyntheses, especially in microfluidic devices.
Synthesis and characterization of poly[1,5-(3,7-di-tert-butyl)naphthyleneethynylene] by alkyne metathesis (2000)

The synthesis and structural characterization of the novel polynaphthylene-ethynylene system is reported. The polymer, poly[1,5-(3,7-di-tert-butyl)naphthyleneethynylene] was obtained by efficient alkyne metathesis of 1,5-dipropynyl-3,7-di-tert-butylnaphthalene, which itself is available in three steps starting from naphthtalene.
Estimation of the CoM and CoP using a 3D body scanning systems: Validation with force plate: A case study (2016)

Human body Center of Mass (CoM) and Center of Pressure (CoP) kinematics are related to stability and balance control. However their evaluation can only be performed in motion analysis lab using different techniques. One of the more accurate is based on the segmental method, in which the body is modelled as a set of rigid bodies, each of which has different mass properties. In this study, we proposed an alternative estimation of the CoM and CoP, based on the segmental method and the 3D scanning of the human body. Knowing the CoM of each segment, the position of the overall CoM and CoP for poses different from the one used during the body acquisition could be predicted. The proposed method was validated by asking to a subject to assume different postures while standing on a force platform by comparing the resulting CoP with the one estimated with the segmental model. Although the approximations introduced in the model results were comparable.
Airplanes aloft as a sensor network for wind forecasting (2014)

We explore the feasibility of using commercial aircraft as sensors for observing weather phenomena at a continental scale. We focus specifically on the problem of wind forecasting and explore the use of machine learning and inference methods to harness air and ground speeds reported by aircraft at different locations and altitudes. We validate the learned predictive model with a field study where we release an instrumented high-altitude balloon and compare the predicted trajectory with the sensed winds. The experiments show the promise of using airplane in flight as a large-scale sensor network. Beyond making predictions, we explore the guidance of sensing with value-of-information analyses, where we consider uncertainties and needs of sets of routes and maximize information value in light of the costs of acquiring data from airplanes. The methods can be used to select ideal subsets of planes to serve as sensors and also to evaluate the value of requesting shifts in trajectories of flights for sensing.
Promoter Methylation-Dependent Silencing of Cell Cycle Tumor Suppressors in Aggressive PNET Is Overcome by Perifosine and HDAC Inhibitors (S35.003) (2013)

OBJECTIVE: Previously our labs have shown that perifosine treatment of medulloblastoma and supratentorial PNET cultures and xenografts induces dramatic p21-dependent growth arrest. To better understand the mechanism of induction of p21 following treatment, studies were performed to better characterize the process of transcriptional activation of CDKN1A and CDKN2A.
Novel Pt-Tm/Carbon Nanocomposite for the Catalyst of Direct Methanol Fuel Cell (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Chain Termination and Transfer Reactions in the Acrylate Polymerization by a Monometallic Chiral Zirconocenium Catalyst System (2006)

Unlike the living polymerization of methacrylates and acrylamides by the monometallic propagating, chiral ansa-zirconocenium ester enolate rac-(EBI)Zr+(THF)[OC(OiPr)CMe2][MeB(C6F5)3]- [1; EBI = C2H4(Ind)2], the polymerization of acrylates such as n-butyl acrylate (n-BA) by 1 proceeds in an uncontrolled fashion to only moderate monomer conversions, producing poly(n-BA) with three types of chain structuresone major linear and two minor cyclic β-ketoester-terminated poly(n-BA) chains. The combined polymerization, chain structure, and model reaction studies have shown the presence of substantial chain termination processes in this system that prevent it from achieving high monomer conversions and producing only the living linear chain structure. The proposed overall three-step mechanism, involving isomerization of the cyclic reactive intermediate, backbiting cyclization to eliminate an alcohol, and chain termination by the alcohol, explains the catalyst deactivation pathways as well as the resulting polymer chain structures. Chain transfer reactions involving acidic α-protons are insignificant as compared to backbiting cyclizations involving the activated antepenultimate ester group of the growing polymer chain, which is the chief catalyst deactivation pathway for the current monometallic catalyst system.
TRAF2 plays a dual role in NF‐κB‐dependent gene activation by mediating the TNF‐induced activation of p38 MAPK and IκB kinase pathways (1998)

We previously demonstrated that p38 MAPK is a crucial mediator in the NF-kappaB-dependent gene activation induced by TNF. Here, we have studied the role of several TNF receptor-associated proteins and caspases in p38 MAPK activation by TNF. The latter appears to be dependent on TRAF2, but independent of FADD or caspases. Remarkably, p38 MAPK activation by TNF proceeds independently of the TRAF2-associated NF-kappaB-inducing kinase NIK, which is known to bind and activate two recently identified IkappaB kinases. These results demonstrate that two kinase pathways involved in NF-kappaB regulation, viz. NIK and p38 MAPK-mediated, diverge at the level of TRAF2.
Supplementary Table S2 from Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer (2023)

&lt;p&gt;ORF overexpression screen enrichment analysis&lt;/p&gt;
Dinitroxide biradical crystals with polar order (2015)

A dinitroxide biradical (dCdO) has the peculiar tendency to crystallize in non-centrosymmetric polar space groups either as a stable dichloromethane solvate or as a pure phase. The molecules arrange with no compensation of their dipolar moment resulting in net macroscopic polar order.
Separation of a target substance from a fluid or mixture using encapsulated sorbents (2023)

Method and apparatus for separating a target substance from a fluid or mixture. Capsules having a coating and stripping solvents encapsulated in the capsules are provided. The coating is permeable to the target substance. The capsules having a coating and stripping solvents encapsulated in the capsules are exposed to the fluid or mixture. The target substance migrates through the coating and is taken up by the stripping solvents. The target substance is separated from the fluid or mixture by driving off the target substance from the capsules.
Effect of prolonged second stage of labor on maternal and neonatal outcomes (2011)

Almost half of puerperas with the length of second stage of labor longer than 2 h underwent vaginal delivery. The prolonged second stage of labor can decrease the score of Apgar scale in 1 min, increase the incidence of asphyxia, but has no effect on scale in 5 min. It still need more evidence from evidence medicine to definition of time and treatment of second stage of labor.
Impact of extrinsic and intrinsic parameter fluctuations on CMOS circuit performance (2000)

The yield of CMOS logic circuits satisfying a specific high performance requirement is demonstrated to be significantly influenced by the magnitude of critical-path delay deviations due to both extrinsic and intrinsic parameter fluctuations. To evaluate the impact of these parameter fluctuations, a static CMOS critical-path delay distribution is calculated from rigorously derived device and circuit models that enable projections for future technology generations. Two possible options are explored to attain a desired yield: (1) reduce performance by operating at a lower clock frequency; and (2) increase the supply voltage and, consequently, power dissipation, to satisfy the nominal critical-path delay. For the 50-nm technology generation, the delay and power dissipation increases are 12%-29% and 22%-6%, respectively, for extrinsic parameter standard deviations ranging from (a) 5% for effective channel length and 0% for gate oxide thickness and channel doping concentration to (b) 10% for effective channel length and 5% for gate oxide thickness and channel doping concentration. Combining both extrinsic and intrinsic fluctuations, the delay and power dissipation increase to 18%-32% and 31%-53%, respectively, thus demonstrating the significance of including the random dopant placement effect in future CMOS logic designs.
Gradient Elution Moving Boundary Electrophoresis Enables Rapid Analysis of Acids in Complex Biomass-Derived Streams (2016)

Biomass conversion processes such as pretreatment, liquefaction, and pyrolysis often produce complex mixtures of intermediates that are a substantial challenge to analyze rapidly and reliably. To characterize these streams more comprehensively and efficiently, new techniques are needed to track species through biomass deconstruction and conversion processes. Here, we present the application of an emerging analytical method, gradient elution moving boundary electrophoresis (GEMBE), to quantify a suite of acids in a complex, biomass-derived streams from alkaline pretreatment of corn stover. GEMBE offers distinct advantages over common chromatography-spectrometry analytical approaches in terms of analysis time, sample preparation requirements, and cost of equipment. As demonstrated here, GEMBE is able to track 17 distinct compounds (oxalate, formate, succinate, malate, acetate, glycolate, protocatechuate, 3-hydroxypropanoate, lactate, glycerate, 2-hydroxybutanoate, 4-hydroxybenzoate, vanillate, p-coumarate, ferulate, sinapate, and acetovanillone). The lower limit of detection was compound dependent and ranged between 0.9 and 3.5 μmol/L. Results from GEMBE were similar to recent results from an orthogonal method based on GC×GC-TOF/MS. Overall, GEMBE offers a rapid, robust approach to analyze complex biomass-derived samples, and given the ease and convenience of deployment, may offer an analytical solution for online tracking of multiple types of biomass streams.
A comparison of analysis in DIS and HLA (1998)

As the Department of Defense (DoD) continually relies more on Modeling and Simulation (M&S) for testing, analyzing, and training, issues of interoperability have become one of the most important concerns. As such, DoD adopted the Distributed Interactive Simulation (DIS) protocol in 1991. Although successful in many aspects, DIS is limited by available information from models, memory and network requirements, and analytical tools available. Therefore, in 1996 the Defense Modeling and Simulation Office (DMSO) released the High Level Architecture (HLA), an object oriented approach to interoperability. This thesis compares these different approaches to analysis to determine functionality in terms of gathering, processing, and reporting on analytical questions in both environments. To compare DIS and HLA analysis, three simulation runs were conducted: Janus vs. Janus in DIS, HLA without an Analysis Federate, and HLA with an Analysis Federate. The Analysis Federate is an HLA compliant software package that gathers and processes information for analysis requirements. The results of the three simulation runs and subsequent analysis demonstrated the techniques and approaches for each infrastructure. The resulting comparison between them show HLA with the Analysis Federate is the easiest and most functional tool. The Analysis Federate fills an analysis void currently in HLA and by implementing it with the study question model tree methodology, an analyst will be more effective and be able to provide real time feedback.