gebhart/patrepeval huggingface dataset:
Supplementary Tables 1-3, Figure Legend from Efficacious Immune Therapy in Chronic Myelogenous Leukemia (CML) Recognizes Antigens That Are Expressed on CML Progenitor Cells (2023)

Supplementary Tables 1-3, Figure Legend from Efficacious Immune Therapy in Chronic Myelogenous Leukemia (CML) Recognizes Antigens That Are Expressed on CML Progenitor Cells
GLP ‐1 Receptor Agonists for the Treatment of Type 2 Diabetes and Obesity (2021)

An alternative to insulin-based therapy treatments of type 2 diabetes mellitus (T2DM) is based on the intriguing peptide hormone glucagon-like-peptide-1 (GLP-1). Several decades passed from the initial discovery of GLP-1 in the 1980s to the launch of the first GLP-1 receptor agonist-based therapy. However, in the past 10 years several new products have been launched, and we continue to learn more and more about this fascinating hormone class both from a biological and structural perspective. The field is continuously growing, and just recently an oral tablet of a GLP-1 receptor agonist was approved by the American Food and Drug Administration for treatment of T2DM. This chapter will provide an overview of the pharmaceutical developments and future directions within GLP-1 receptor agonist-based therapies.
CELL BIOLOGY SYMPOSIUM: Feed efficiency: Mitochondrial function to global gene expression12 (2012)

Understanding the cellular basis of feed efficiency (FE) is instrumental to helping poultry and livestock industries continue to provide high-quality protein for an increasingly crowded world. To understand relationships of FE and gene expression, global RNA transcription was investigated in breast muscle obtained from a male broiler line fed the same diet and individually phenotyped for FE. In these studies, RNA samples obtained from broilers that exhibited either high FE (0.65 ± 0.01) or low FE (0.46 ± 0.01) were analyzed with an Agilent 44K chicken oligoarray. A 1.3-fold cutoff in expression (30% difference between groups) resulted in 782 genes that were differentially expressed (P < 0.05) in muscle between the high- and low-FE phenotypes. Ingenuity Pathway Analysis, an online software program, was used to identify genes, gene networks, and pathways associated with the phenotypic expression of FE. The results indicate that the high-FE phenotype exhibited increased expression of genes associated with 1) signal transduction pathways, 2) anabolic activities, and 3) energy-sensing and energy coordination activities, all of which would likely be favorable to cell growth and development. In contrast, the low-FE broiler phenotype exhibited upregulation of genes 1) associated with actin-myosin filaments, cytoskeletal architecture, and muscle fibers and 2) stress-related or stress-responsive genes. Because the low-FE broiler phenotype exhibits greater oxidative stress, it would appear that the low-FE phenotype is the product of inherent gene expression that is modulated by oxidative stress. The results of these studies begin to provide a comprehensive picture of gene expression in muscle, a major organ of energy demand in an animal, associated with phenotypic expression of FE.
Automatic data aggregation for software distributed shared memory systems (1997)

Automatic Data Aggregation for Software Distributed Shared Memory Systems by Karthick Rajamani Software Distributed Shared Memory (DSM) provides a shared-memory abstraction on distributed memory hardware, making a parallel programmer&amp;apos;s task easier. Unfortunately, software DSM is less efficient than the direct use of the underlying message-passing hardware. The chief reason for this is that hand-coded and compilergenerated message-passing programs typically achieve better data aggregation in their messages than programs using software DSM. Software DSM has poorer data aggregation because the system lacks the knowledge of the application&amp;apos;s behavior that a programmer or compiler analysis can provide. We propose four new techniques to perform automatic data aggregation in software DSM. Our techniques use run-time analysis of past data-fetch accesses made by a processor, to aggregate data movement for future accesses. They do not need any additional compiler support. We implemented our tec...
Adaptive space-time feedforward/feedback detection for high data rate CDMA in frequency-selective fading (2001)

We investigate linear and nonlinear space-time minimum mean-square-error (MMSE) multiuser detectors for high data rate wireless code-division multiple-access (CDMA) networks. The centralized reverse-link detectors comprise a space-time feedforward filter and a multiuser feedback filter which processes the previously detected symbols of all in-sector users. The feedforward filter processes chip-rate samples from a bank of chip-matched filters which operate on the baseband outputs from an array of antennas. We present an adaptive multiuser recursive least squares (RLS) algorithm which determines the MMSE adjusted filter coefficients with less complexity than individual adaptation for each user. We calculate the outage probabilities and isolate the effects of antenna, diversity, and interference suppression gains for linear and nonlinear filtering and for CDMA systems with varying levels of system control (e.g., timing control, code assignment, cell layout). For eight users transmitting uncoded 2-Mb/s quadrature phase-shift keying with a spreading gain of eight chips per symbol over a fading channel with a multipath delay spread of 1.25 /spl mu/s, the performance of a three-antenna feedforward/feedback detector was within 1 dB (in signal-to-noise ratio per antenna) of ideal detection in the absence of interference. By training for 10% of a 5-ms frame, RLS adaptation enabled the same detector to suffer less than a 0.5-dB penalty due to the combined effects of imperfect coefficients and error propagation. The advantage of nonlinear feedforward/feedback detection over linear feedforward detection was shown to be significantly larger for a CDMA system with enhanced system control.
Poly(di-n-pentylsilane). The spectral consequences of a helical conformation in the solid state (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPoly(di-n-pentylsilane). The spectral consequences of a helical conformation in the solid stateR. D. Miller, B. L. Farmer, W. Fleming, R. Sooriyakumaran, and J. RaboltCite this: J. Am. Chem. Soc. 1987, 109, 8, 2509–2510Publication Date (Print):April 1, 1987Publication History Published online1 May 2002Published inissue 1 April 1987https://pubs.acs.org/doi/10.1021/ja00242a044https://doi.org/10.1021/ja00242a044research-articleACS PublicationsRequest reuse permissionsArticle Views123Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Prospects for Real‐Time Raman Spectroscopy for Oesophageal Neoplasia (2013)

Raman spectroscopy can provide exquisite sensitivity for molecular analysis of degenerating pre malignant changes in the oesophagus. We are interested in the prospect of rapid endoscopic diagnosis during endoscopy using Raman. The early changes of dysplasia are invisible to white‐light inspection. If detected, the dysplastic area can then be immediately removed and the surrounding area treated. The problem has been that histopathological classification, which is very challenging in these very early abnormalities. We have built prognostic models to classify these areas of abnormality and related the spectral classification to the patient prognosis and development of invasive cancer. The hypothesis is that the Raman signature allows biochemical detection at a biochemical and molecular level prior to morphological changes within the tissue. It is becoming clear that the dependence on the histological appearance of cells to establish a diagnosis of these early changes is subject to great variation and can be highly subjective. In addition, pathological analysis of tissue is very time consuming, expensive, and requires tissue biopsy. Kerkhof et al. demonstrated a poor level of interobserver agreement between expert histopathologists (K=0.58) in the grading of low‐grade (LGD) and high‐grade (HGD) oesophageal dysplasia. This distinction has vital consequences for patient management as LGD can be monitored by serial surveillance endoscopy, whereas HGD necessitates early endoscopic therapy or even surgery, and carries a significant risk of malignant progression. As well as being difficult to classify histologically, dysplasia can be extremely difficult or even impossible to recognise at endoscopy. Raman spectroscopy (RS) could remove the subjectivity from the histopathological assessment by measuring precise biochemical information about the target tissue. A Raman fibre‐optic probe could also enable real‐time diagnosis facilitating immediate treatment of suspicious areas of tissue during endoscopy, and could be used as a surgical adjunct.
OC14.05: Hysterosalpingo‐Foam Sonography (HyFoSy); first experiences with Hysterosalpingo‐Contrast Sonography (HyCoSy) with Foam (2011)

To describe first experiences with a new technique with the use of foam for direct imaging of tubal patency during transvaginal ultrasonography. In 2007 a new technique, gel instillation sonohysterography (GIS), was introduced to improve diagnostic accuracy and to overcome disadvantages of saline infusion sonohysterography (SIS). One of the disadvantages of the use of transsonic fluids however is the poor visualization of tubal passage. A for this purpose special echogenic ultrasound contrast medium (Echovist®) was recently taken off the market. A simple and cheap alternative is presented by mixing ExEm® Gel and purified water creating a foam. This foam can be easily infused into the uterine cavity and fallopian tubes to demonstrate tubal patency. Since 2010 73 patients with a history of subfertility were examined. In 67/73 (92%) patients the procedure was successful. In 55/73 (75%) patients both tubes were open and there was no need for further examination. In 12 patients one or both tubes were blocked; in 5 of them HSG findings were discordant. In 6/73 (8%) patients no adequate uterine filling could be achieved. All procedures were uneventful. 14/67 (20%) patients conceived spontaneously within a mean of 3 months. Tubal patency can be easily recognized by HyCoSy with foam. In 75% of the cases there was no need for further examination. It seems reasonable to expect that the use of HyCoSy with Foam will be an acceptable cheap and simple first screening method for tubal patency. Supporting information can be found in the online version of this abstract. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Acellular vaccines for preventing whooping cough in children (2014)

Multi-component (≥ three) aP vaccines are effective in preventing whooping cough in children. Multi-component aP vaccines have higher efficacy than low-efficacy wP vaccines, but they may be less efficacious than the highest-efficacy wP vaccines. Acellular vaccines have fewer adverse effects than whole-cell vaccines for the primary series as well as for booster doses.
Poly(sulfonium cation) for the Synthesis of High-Molecular-Weight Poly(phenylene sulfide) (1996)

High molecular weight poly(phenylene sulfide)(PPS), Mw > 2 x 105, was synthesized via a poly(sulfonium cation) through oxidative polymerization of methyl 4-(phenylthio)phenyl sulfoxide. Polymerization proceeds in protic acid homogeneously. The poly(sulfonium cation) was soluble in common solvents such as acetonitrile, acetone, formic acid and dimethyl sulfoxide. The poly(sulfonium cation) was available as a soluble intermediate for the synthesis of high molecular weight poly(phenylene sulfide). It was feasible to convert high molecular weight poly(arylene sulfide) through the Sn2 reaction with pyridine as a nucleophile. This polymerization is applicable to the synthesis of new block copolymers such as, poly(phenylene sulfide)-block-[poly(tetrafluoroethylene-co-per-fluoro (propylvinyl ether)]}-block-poly(phenylene sulfide). The poly-sulfonium cation is isolatable as a stable salt which acts as an unique polymeric reagent for the methylation of aromatic compounds having mobile hydrogen.
Next generation geophysical sensing: exploring a new wave of geophysical technologies for the energy transition (2021)

Disclaimer Text and Data Mining. Any automated analytical technique aimed at analysing text and data in digital form in order to generate information including - but not limited to - patterns, trends and correlations (so-called Text and Data Mining) may only be applied if it is done by a research organisation or cultural heritage institution solely for the purpose of (non-commercial) scientific research as mentioned in Clause 3 of Directive (EU) 2019/790 (the Digital Single Market Directive) and Clause 15n of the Dutch Copyright Act [Auteurswet]. Text and Data Mining for commercial purposes is not allowed; all rights in this respect are reserved pursuant to Clause 4 paragraph 3 of the Digital Single Market Directive and Clause 15o paragraph 1 of the Dutch Copyright Act.
Human complement‐activating immunoglobulin (Ig)G3 antibodies are essential for porcine endothelial cell activation (2006)

Collectively, these data strengthen the hypothesis that human anti-porcine endothelial cell Abs of the IgG3 subclass are essential for endothelial cell activation in porcine-to-human species grafts and demonstrate such activation to be partly independent of Gal epitopes.
Semidilute athermal polymer solutions near a hard wall (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSemidilute athermal polymer solutions near a hard wallWan Y. Shih, Wei Heng Shih, and Ilhan A. AksayCite this: Macromolecules 1990, 23, 13, 3291–3296Publication Date (Print):June 1, 1990Publication History Published online1 May 2002Published inissue 1 June 1990https://pubs.acs.org/doi/10.1021/ma00215a015https://doi.org/10.1021/ma00215a015research-articleACS PublicationsRequest reuse permissionsArticle Views32Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A neural network approach to handprint character recognition (2002)

The authors outline OCR (optical character recognition) technology developed at AT&T Bell Laboratories, including a recognition network that learns feature extraction kernels and a custom VLSI chip that is designed for neural-net image processing. It is concluded that both high speed and high accuracy can be obtained using neural-net methods for character recognition. Networks can be designed that learn their own feature extraction kernels. Special-purpose neural-net chips combined with digital signal processors can quickly evaluate character-recognition neural nets. This high speed is particularly useful for recognition-based segmentation of character strings.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Acute In Vivo Performance Evaluation of the Fluorescence Affinity Sensor in the Intravascular and Interstitial Space in Swine (2013)

The study demonstrated that the performance level of the FAS device implanted in interstitial tissue and blood can be very high. However, under certain circumstances, exogenous insulin caused the glucose concentration in interstitial tissue to be lower than in blood, which resulted in an overall lower level of accuracy of the FAS device. How significant this physiological effect is in insulin-treated persons with diabetes remains to be seen. In contrast, the level of accuracy of the FAS device in blood was very high because of high mass transfer conditions in blood. While the use of the FAS in both body sites will need further validation, its application in critically ill patients looks particularly promising.
High-performance forensic DNA profiling using fluorescence energy transfer primers and a 96-lane microfabricated capillary array electrophoresis device (2008)

We present a 96-channel microfabricated capillary array electrophoresis (muCAE) device for fluorescence energy- transfer (ET) dye labeled short tandem repeat (STR) genotyping. The 96-channel muCAE system produced high-speed (<30 min), highly parallel DNA separations with single-base resolution. To achieve higher sensitivity of STR typing, we adapted ET dye labeling method, and the resultant ET 16-plex amplicons which are the markers used in the commercial STR typing kit PowerPlex 16 displayed 1.6-8.7 fold increased fluorescence intensities and improved limit of detection compared to those produced using the single-dye labeled multiplex kit. In addition, the ET 16-plex generated complete STR profiles with only 28 PCR cycles; this capability should improve low copy number (LCN) typing by reducing the amplification time and background, thereby providing higher successful profiling rate. To confirm the practical advantages of ET-labeled primers, six previously problematic sexual casework samples were tested and only the ET 16-plex kit was able to capture additional DNA allele data. The successful development and demonstration of ET cassette labeled primers for higher sensitivity STR typing offers a simple solution to improving current commercial multiplex typing capability. The pairing of ET cassette technology with the muCAE system illustrates not only an enhanced STR typing platform, but also a significant step toward a higher-efficiency integrated forensic system.
A General Method for the Chromosomal Amplification of Genes in Yeast (1988)

The yeast retrotransposon Ty can be used to insert multiple copies of a gene at new sites in the genome. The gene of interest is inserted into a GALI-Ty fusion construct; the entire "amplification cassette" is then introduced into yeast on a high copy number plasmid vector. Transposition of the Ty element carrying the gene occurs at multiple sites in the genome. Two genes, a bacterial neomycin phosphotransferase gene and the yeast TRPl gene, were amplified in this way. Although the amplified genes were about 1 kilobase in length, they were amplified to about the same extent as a 40-base pair segment. The benefit of this "shotgun" approach is that amplification can be achieved in one set of manipulations.
Experimental verification of an optical negative-index material (2005)

Comprehensive studies for a periodic array of gold nanorod pairs demonstrate its unique optical properties, including a negative refractive index in the optical range.
Supercapacitive microbial fuel cell: Characterization and analysis for improved charge storage/delivery performance (2016)

Supercapacitive microbial fuel cells with various anode and cathode dimensions were investigated in order to determine the effect on cell capacitance and delivered power quality. The cathode size was shown to be the limiting component of the system in contrast to anode size. By doubling the cathode area, the peak power output was improved by roughly 120% for a 10ms pulse discharge and internal resistance of the cell was decreased by ∼47%. A model was constructed in order to predict the performance of a hypothetical cylindrical MFC design with larger relative cathode size. It was found that a small device based on conventional materials with a volume of approximately 21cm(3) would be capable of delivering a peak power output of approximately 25mW at 70mA, corresponding to ∼1300Wm(-3).
Combining tandem and hybrid systems for improved speech recognition and keyword spotting on low resource languages (2014)

Copyright © 2014 ISCA. In recent years there has been significant interest in Automatic Speech Recognition (ASR) and KeyWord Spotting (KWS) systems for low resource languages. One of the driving forces for this research direction is the IARPA Babel project. This paper examines the performance gains that can be obtained by combining two forms of deep neural network ASR systems, Tandem and Hybrid, for both ASR and KWS using data released under the Babel project. Baseline systems are described for the five option period 1 languages: Assamese; Bengali; Haitian Creole; Lao; and Zulu. All the ASR systems share common attributes, for example deep neural network configurations, and decision trees based on rich phonetic questions and state-position root nodes. The baseline ASR and KWS performance of Hybrid and Tandem systems are compared for both the "full", approximately 80 hours of training data, and limited, approximately 10 hours of training data, language packs. By combining the two systems together consistent performance gains can be obtained for KWS in all configurations.
Room‐Temperature Phosphorescence from a Series of 3‐Pyridylcarbazole Derivatives (2019)

Exploration of pure metal-free organic molecules that exhibit strong room-temperature phosphorescence (RTP) is an emerging research topic. In this regard, unveiling the design principles for an efficient RTP molecule is an essential, but challenging, task. A small molecule is an ideal platform to precisely understand the fundamental role of each functional component because the parent molecule can be easily derivatized. Here, the RTP behaviors of a series of 3-pyridylcarbazole derivatives are presented. Experimental studies in combination with theoretical calculations reveal the crucial role of the n orbital on the central pyridine ring in the dramatic enhancement of the intersystem crossing between the charge-transfer-excited singlet state and the locally excited triplet states. Single-crystal X-ray crystallographic studies apparently indicate that both the pyridine ring and fluorine atom contribute to the enhancement of the RTP because of the restricted motion owing to weak C-H⋅⋅⋅N and H⋅⋅⋅F hydrogen-bonding interactions. The single crystal of the fluorine-substituted derivative shows an ultra-long phosphorescent lifetime (τ<sub>P</sub> ) of 1.1 s and a phosphorescence quantum yield (Φ<sub>P</sub> ) of 1.2 %, whereas the bromine-substituted derivative exhibits τ<sub>P</sub> of 0.15 s with a Φ<sub>P</sub> of 7.9 %. We believe that this work provides a fundamental and universal guideline for the generation of pure organic molecules exhibiting strong RTP.