gebhart/patrepeval huggingface dataset:
Genes encoding the phycobilisome rod substructure are clustered on the Anabaena chromosome: characterization of the phycoerythrocyanin operon (1992)

The phycoerythrocyanin (pec) operon, cloned from Anabaena sp. strain PCC 7120, encodes four genes, pecBACE, located upstream of the C-phycocyanin (cpc) operon. This pec-cpc cluster includes all the genes for the structural components of the phycobilisome rod. Oligonucleotide probes based on the amino-terminal sequence of the phycoerythrocyanin beta subunit were used to clone an 8.0-kbp EcoRI fragment which was determined, by sequencing, to partially overlap the previously cloned cpc operon. A 5.0-kbp EcoRI-ClaI fragment corresponding to the region upstream of the cpc operon was subsequently subcloned and sequenced. Five open reading frames whose polarity of transcription is parallel to that of the cpc genes were identified. pecB and pecA encode the beta and alpha subunits of phycoerythrocyanin, respectively. pecC encodes the phycoerythrocyanin-associated linker polypeptide LR34.5,PEC. The identities of these genes are confirmed by agreement with amino-terminal sequences determined from purified phycobilisome components. A gene homologous to cpcE, found downstream of pecC, has been designated pecE. The cpcE gene product is involved in the attachment of the phycocyanobilin chromophore to the alpha subunit of phycocyanin. Three transcripts were observed by Northern (RNA) analyses. The most abundant of these transcripts, 1.35 kbp, corresponds to the beta and alpha subunit genes, whereas the less-abundant transcripts, 2.3 and 3.1 kbp, correspond to pecBAC and pecBACE, respectively. Phycoerythrocyanin is strongly induced in cells cultured under low light. In parallel, all three transcripts were present at much higher levels in cells cultured under low light.
Constitutive Agonist-independent CCR5 Oligomerization and Antibody-mediated Clustering Occurring at Physiological Levels of Receptors (2002)

Although homo-oligomerization has been reported for several G protein-coupled receptors, this phenomenon was not studied at low concentrations of receptors. Furthermore, it is not clear whether homo-oligomerization corresponds to an intrinsic property of nascent receptors or if it is a consequence of receptor activation. Here CCR5 receptor oligomerization was studied by bioluminescence resonance energy transfer (BRET) in cells expressing physiological levels of receptors. A strong energy transfer could be observed, in the absence of ligands, in whole cells and in both endoplasmic reticulum and plasma membrane subfractions, supporting the hypothesis of a constitutive oligomerization that occurs early after biosynthesis. No change in BRET was observed upon agonist binding, indicating that the extent of oligomerization is unrelated to the activation state of the receptor. In contrast, a robust increase of BRET, induced by a monoclonal antibody known to promote receptor clustering, suggests that microaggregation of preformed receptor homo-oligomers can occur. Taken together, our data indicate that constitutive receptor homo-oligomerization has a biologically relevant significance and might be involved in the process of receptor biosynthesis.
Detection of optically distributed clock signals for very large scale integrated circuits (1985)

The miniaturization of integrated circuit elements by scaling in very large scale integrated circuits (VLSI) has created a great deal of interest in the timing skew associated with transmitting signals via circuit lines to remote locations on a chip. As device sizes decrease and chip sizes increase with technological advances, the speed of the circuits on a VLSI chip becomes limited by signal transmission delays rather than device switching delays. Of particular interest is the clock signal that allows the system operations to be timed synchronously with one another. Parasitic transmission line capacitance and resistance over varying path lengths for this widely distributed signal cause a skew in its arrival time at different locations on the chip. In our approach, the 3-D nature of imaging optics is utilized to distribute the clock signal to multiple detectors. The chip is divided into functional areas within which transmission line delays are negligible, and the clock signal is distributed optically to a detector in each region. In this manner, interregional skew effects are reduced to the variation of switching speeds of the detectors and amplifiers in different functional areas, and intraregional skew effects are negligible. In addition, the division of the chip into smaller areas allows the capacitive load for each clock driver to be orders of magnitude less than that typical of chip-wide clock drivers. SPICE circuit simulations show that this difference in loading allows the optical clock driver transition delay to be less than the chip-wide electronic clock driver transition delay by a factor of 4. Design and fabrication of test circuits to measure transition delay for the optical circuit and photocurrent leakage effects in 4- µ m CMOS technology are now in progress.
Synthesis and characterization of a lacunar bis(isothiocyanato)cobalt(III) cyclidene complex: a structural model for distal steric effects in hemoproteins (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and characterization of a lacunar bis(isothiocyanato)cobalt(III) cyclidene complex: a structural model for distal steric effects in hemoproteinsPatricia J. Jackson, Colin Cairns, Wang Kan Lin, Nathaniel W. Alcock, and Daryle H. BuschCite this: Inorg. Chem. 1986, 25, 22, 4015–4020Publication Date (Print):October 1, 1986Publication History Published online1 May 2002Published inissue 1 October 1986https://pubs.acs.org/doi/10.1021/ic00242a038https://doi.org/10.1021/ic00242a038research-articleACS PublicationsRequest reuse permissionsArticle Views45Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Trapping of Neutral Sodium Atoms with Radiation Pressure (1987)

We report the confinement and cooling of an optically dense cloud of neutral sodium atoms by radiation pressure. The trapping and damping forces were provided by three retroreflected laser beams propagating along orthogonal axes, with a weak magnetic field used to distinguish between the beams. We have trapped as many as ${10}^{7}$ atoms for 2 min at densities exceeding ${10}^{11}$ atoms ${\mathrm{cm}}^{\ensuremath{-}3}$. The trap was \ensuremath{\simeq}0.4 K deep and the atoms, once trapped, were cooled to less than a millikelvin and compacted into a region less than 0.5 mm in diameter.
Performance limitations in vehicle platoon control (2012)

One of the major benefits of driving vehicles in controlled, close formations such as platoons is that of reduced air drag. However, this will set hard performance requirements on the system actuators, sensors and controllers of each vehicle. This paper analyzes the effects of fundamental limitations on the longitudinal and lateral control performance of a platoon and the effects on following distance, perceived safety and fuel economy. The trade-off between minimizing fuel consumption and maintaining a safe following distance is analyzed and described. The analysis is based on fundamental properties of linear systems such as Bode's phase area relation. Design guidelines are proposed and results from vehicle testing are presented.
Symbol-Level Precoding Design Based on Distance Preserving Constructive Interference Regions (2018)

In this paper, we investigate the symbol-level precoding (SLP) design problem in the downlink of a multiuser multiple-input single-output channel. We consider generic two-dimensional constellations with any shape and size, and confine ourselves to one of the main categories of constructive interference regions (CIR), namely distance preserving CIR (DPCIR). We provide a comprehensive study of DPCIRs and derive several properties for these regions. Using these properties, we first show that any signal in a given DPCIR has a norm greater than or equal to the norm of the corresponding constellation point if and only if the convex hull of the constellation contains the origin. It is followed by proving that the power of the noise-free received signal in a DPCIR is a monotonic strictly increasing function of two parameters relating to the infinite Voronoi edges. Using the convex description of DPCIRs and their characteristics, we formulate two design problems, namely the SLP power minimization with signal-to-interference-plus-noise ratio (SINR) constraints, and the SLP SINR balancing problem under max–min fairness criterion. The SLP power minimization based on DPCIRs can straightforwardly be written as a quadratic programming. We derive a simplified reformulation of this problem, which is less computationally complex. The SLP max–min SINR, however, is non-convex in its original form, and hence difficult to tackle. We propose alternative optimization approaches, including semidefinite programming formulation and block coordinate descent optimization. We discuss and evaluate the loss due to the proposed alternative methods through extensive simulation results.
Data, Privacy, and the Greater Good (2019)

Large-scale aggregate analyses of anonymized data can yield valuable results and insights that address public health challenges and provide new avenues for scientific discovery. These methods can extend our knowledge and provide new tools for enhancing health and well-being. However, they raise questions about how to best address potential threats to privacy while reaping benefits for individuals and for society as a whole. The use of machine learning to make leaps across informational and social contexts to infer health conditions and risks from nonmedical data provides representative scenarios for reflections on directions with balancing innovation and regulation.
Extracorporeal Virus Elimination for the Treatment of Severe Ebola Virus Disease - First Experience with Lectin Affinity Plasmapheresis (2014)

Therapeutic options for Ebola virus disease (EVD) are currently limited to (1) best supportive care, and (2) evolving virus-specific therapies, resulting from decades of analyzing one of the world's deadliest diseases. Supportive care ranges from oral or intravenous rehydration therapy and anti-emetics in developing countries to much more extensive life-support interventions in resource-rich countries. Current EVD-specific therapies attempt to either interfere with the earliest steps of viral replication or to elicit a strong immune response against the virus. An entirely new approach is the extracorporeal elimination of viruses and viral glycoproteins by lectin affinity plasmapheresis. Herein, we report for the first time the successful and safe use of lectin affinity plasmapheresis in a patient with severe Ebola virus disease.
A 64-state 2GHz 500Mbps 40mW Viterbi accelerator in 90nm CMOS (2004)

A 64-state Viterbi accelerator fabricated in 1.2V, 90nm dual-Vt CMOS technology is described for 2GHz operation and fastest reported 500Mbps data rate (1 Gbps decode for 1/2 rate codes). Novel radix-4 add-compare-select circuits and low-energy traceback register file techniques enable 40mW total power at 1.2V, 2GHz, and scalability to 5mW at 0.7V, 216MHz (for 802.11 a wireless baseband).
Testing the delivery of human organ transportation with drones in the real world (2022)

Last-mile transportation of human donor lungs in a densely populated urban environment has been made possible with drones.
Perfluorosulfonated Ionomer-Modified Polyethylene. A Material for Simultaneous Solid-Phase Enrichment and Enhanced Precolumn Dansylation of C-21 Ketosteroids in Human Serum (2001)

A new derivatization procedure has been developed where solid-phase catalysis is utilized to facilitate the formation of hydrazones in precolumn labeling of keto-containing compounds. This procedure has been implemented on a solid-phase enrichment and enhanced derivatization (SPEED) device, prepared from porous polyethylene that has been coated with Nafion and dansylhydrazine. The SPEED devices have been optimized using experimental design and characterized for dansylation of C-21 ketosteroids by multivariate data analysis, using progesterone as the model compound. The reaction temperature and the molar ratio between the steroid and the derivatization reagent were found to be the factors most strongly affecting the reaction. Faster reaction kinetics were achieved when the molar ratio between dansylhydrazine and the steroid was increased. Mass spectroscopic analysis showed that the four derivative peaks eluting when derivatized progesterone was separated on an octadecyl silica stationary phase were due to the syn and anti mono- and bis(hydrazones) formed in the reaction. Using optimal reaction conditions, the derivatives mainly constitute the syn and anti conformers of bis-derivatives. In contrast to solution-based acid catalysis, the SPEED device was remarkably insensitive to water in the reaction mixture. A sample volume of 400 microL was found to be the maximum, enabling sample enrichment prior derivatization. Using optimal experimental conditions, picomole amounts of ketosteroids could be derivatized in 10 min at room temperature. Analysis of spiked serum samples containing 0.4-2.0 nmol of progesterone showed overall recoveries of 52-63%. The corresponding 3delta detection limit was 1.3 pmol (n = 4, 100 microL injected), as estimated from calibration curve data.
Efficacy of Reduced-Intensity Chemotherapy With Oxaliplatin and Capecitabine on Quality of Life and Cancer Control Among Older and Frail Patients With Advanced Gastroesophageal Cancer (2021)

isrctn.org Identifier: ISRCTN44687907.
Evidence favouring the efficacy of convalescent plasma for COVID-19 therapy (2020)

To determine the effect of COVID-19 convalescent plasma on mortality, we aggregated patient outcome data from 10 randomized clinical trials (RCT), 20 matched-control studies, two dose-response studies, and 96 case-reports or case series. Studies published between January 1, 2020 to January 16, 2021 were identified through a systematic search of online PubMed and MEDLINE databases. Random effects analyses of RCT and matched-control data demonstrated that COVID-19 patients transfused with convalescent plasma exhibited a lower mortality rate compared to patients receiving standard treatments. Additional analyses showed that early transfusion (within 3 days of hospital admission) of higher titer plasma is associated with lower patient mortality. These data provide evidence favoring the efficacy of human convalescent plasma as a therapeutic agent in hospitalized COVID-19 patients.
Alkaline Earth Guests in Polyoxopalladate Chemistry: From Nanocube to Nanostar via an Open‐Shell Structure (2014)

The three novel, discrete palladium(II)-oxo clusters [CaPd12O8(PhAsO3)8](6-) (CaPd12), [SrPd12O6(OH)3(PhAsO3)6(OAc)3](4-) (SrPd12), and [BaPd15O10(PhAsO3)10](8-) (BaPd15) encapsulating alkaline earth metal ions were prepared and fully characterized by a multitude of solution and solid-state physicochemical techniques. We have discovered a structure-directing template effect induced by the respective size of the alkaline earth guest ion, which determines the detailed condensation arrangement of the peripheral Pd(II)-oxo shell. The unprecedented SrPd12 with an open-shell type structure is of particular importance and reflects a successful strategy for deliberate design of new structural classes of polyoxo-noble-metalates. Furthermore, the unusual acetate-water ligand exchange phenomenon renders SrPd12 as a promising candidate for noble-metal-based catalysis.
Insights into the Effects of Electrolyte Composition on the Performance and Stability of FeF2 Conversion‐Type Cathodes (2019)

Abstract As an alternative to commercial Ni‐ and Co‐based intercalation‐type cathode materials, conversion‐type metal fluoride (MF x ) cathodes are attracting more interest due to their promises to increase cell‐level energy density when coupled with lithium (Li) or silicon (Si)‐based anodes. Among metal fluorides, iron fluorides (FeF 2 and FeF 3 ) are regarded as some of the most promising candidates due to their high capacity, moderately high potential and the very low cost of Fe. In this study, the impacts of electrolyte composition on the performance and stability of nanostructured FeF 2 cathodes are systematically investigated. Dramatic impacts of Li salt composition, Li salt concentration, solvent composition, and cycling potential range on the cathode's most critical performance parameters—stability, capacity, rate, and voltage hysteresis are discovered. In contrast to previous beliefs, it is observed that even if the Fe 2+ cation dissolution could be avoided, the dissolution of F − anions may still negatively affect cathode performance. Formation of the more favorable cathode solid electrolyte interface (CEI) is found to minimize both processes.
Influence of SeOCl2 on the polymerization of propylene by TiCl3–Al(C2H5)3 (1967)

Abstract The influence of SeOCl 2 on the polymerization of propylene by TiCl 3 –Al(C 2 H 5 ) 3 , and the temperature dependence of the stereospecificity of the catalyst, TiCl 3 –Al(C 2 H 5 ) 3 , have been investigated. SeOCl 2 decreases the rate of polymerization and increase the stereospecificity of the catalyst, which could be explained on the basis of a decrease of the concentration of Al(C 2 H 5 ) 3 accompanied by a reaction between Al(C 2 H 5 ) 3 and SeOCl 2 . On the other hand, the stereospecificity of the catalyst, TiCl 3 –Al(C 2 H 5 ) 3 , increases gradually with a decrease in polymerization temperature from 40 to 0°C. From these results, we conclude that SeOCl 2 exerts no essential influence on the polymerization of propylene by TiCl 3 –Al(C 2 H 5 ) 3 , and that the stereospecificity of the catalyst is attributed mainly to the reducing ability of the organometallic compound.
Spatio-temporal invariants of the time reversal operator (2010)

The decomposition of the time reversal operator, known by the French acronym DORT, is a technique to extract point scatterers' monochromatic Green's functions from a medium. It is used to detect, locate, and focus on scatterers in various domains such as underwater acoustics, medical ultrasound, and nondestructive evaluation. A limitation of the method arises from its single-frequency nature, when the signals used in acoustics are often broadband. Reconstruction of the broadband Green's functions from the single-frequency Green's functions can be very difficult when numerous scatterers are present in the medium. Moreover, the method does not take advantage of the axial resolution associated with broadband signals. Time domain methods are investigated here as an answer to these problems. It is shown that the time reversal operator in the time domain takes the form of a tensor. The properties of the invariants are discussed. It is shown they do not have all the expected properties. Another method is proposed that requires a priori information on the medium.
Design of SOI wavelength filter based on multiple MMIs structures (2011)

SOI based MMIs prove to be versatile photonic structures for optical power splitting/combining, directional coupling, wavelength multiplexing/demultiplexing, etc. Such a structure benefits from relative ease of fabrication, low sensitivity to fabrication error and low temperature dependence. Whilst the majority of previous designs and optimizations investigated single MMIs, there is significant potential to combine MMIs within a single device for the realization of improved device performance. We have designed and simulated a wavelength filter device consisting of a series of MMIs with different lengths. The bandwidth, free spectral range, and extinction ratio can be controlled by changing the MMI's width and length. We have optimized our design to achieve a -3dB bandwidth of 5nm, a free spectral range of 60nm, an extinction ratio of &gt;30dB, and a side peak suppression ratio of &gt;22dB. Such a device can be used for high performance coarse wavelength filtering. The whole structure can fit into a 70&mu;m×300&mu;m area. Temperature sensitivity of the designed structures was also investigated.
Gas Phase Organic Functionalization of SiO2 with Propanoyl Chloride (2018)

The reaction mechanism of propanoyl chloride (C<sub>2</sub>H<sub>5</sub>COCl) with -SiOH-terminated SiO<sub>2</sub> films was studied using in situ surface infrared spectroscopy. We show that this surface functionalization reaction is temperature dependent. At 230 °C, C<sub>2</sub>H<sub>5</sub>COCl reacts with isolated surface -SiOH groups to form the expected ester linkage. Surprisingly, as the temperature is lowered to 70 °C, the ketone groups are transformed into the enol tautomer, but if the temperature is increased back to the starting exposure temperature of 230 °C, the ketone tautomer is not recovered, indicating that the enol form is thermally stable over a wide range of temperatures. Further, the enol form is directly formed after exposure of a SiO<sub>2</sub> surface to C<sub>2</sub>H<sub>5</sub>COCl at 70 °C. We speculate that the enol form, which is energetically unfavorable, is stabilized because of hydrogen bonding with adjacent enol groups or through hydrogen bonding with unreacted surface -SiOH groups. The surface coverage of hydrocarbon molecules is calculated as ∼6 × 10<sup>12</sup> cm<sup>-2</sup>, assuming each reacted -SiOH group contributes to one hydrocarbon linkage on the surface. At a substrate temperature of 70 °C, the enol form is unreactive with H<sub>2</sub>O, and H<sub>2</sub>O molecules simply physisorb on the surface. At higher temperatures, H<sub>2</sub>O converts the ketone to the enol tautomer and reacts with Si-O-Si bridges, forming more -SiOH reactive sites. The overall hydrocarbon coverage on the surface can then be further increased through cycling H<sub>2</sub>O and C<sub>2</sub>H<sub>5</sub>COCl doses.
Complementary inverter using high mobility air-stable perylene di-imide derivatives (2007)

The authors report the fabrication and electrical characterization of organic complementary inverters using pentacene as p-type material and our previously reported air-stable perylene di-imide derivatives tetrachloro-perylene-tetracarboxyldi-imide (TC-PTCDI) and N,N′-bis(2-phenylethyl)perylene-3,4:9:10-bis-(dicarboximide) (BPE-PTCDI) as n-type materials. Both p- and n-type thin film transistors were integrated onto the same substrate using a top contact configuration. The corresponding inverters show good performance with gains about 12 and 10 for TC-PTCDI and BPE-PTCDI inverters, respectively.
Power--bandwidth limitations of an optical resonance (2015)

We present shape-independent upper limits to the power--bandwidth product for a single resonance in an optical scatterer, with the bound depending only on the material susceptibility. We show that quasistatic metallic scatterers can nearly reach the limits, and we apply our approach to the problem of designing $N$ independent, subwavelength scatterers to achieve flat, broadband response even if they individually exhibit narrow resonant peaks.