gebhart/patrepeval huggingface dataset:
A novel HSP90 inhibitor SL-145 suppresses metastatic triple-negative breast cancer without triggering the heat shock response (2022)

Despite recent advances, there remains a significant unmet need for the development of new targeted therapies for triple-negative breast cancer (TNBC). Although the heat shock protein HSP90 is a promising target, previous inhibitors have had issues during development including undesirable induction of the heat shock response (HSR) and off-target effects leading to toxicity. SL-145 is a novel, rationally-designed C-terminal HSP90 inhibitor that induces apoptosis in TNBC cells via the suppression of oncogenic AKT, MEK/ERK, and JAK2/STAT3 signaling and does not trigger the HSR, in contrast to other inhibitors. In an orthotopic allograft model incorporating breast cancer stem cell-enriched TNBC tumors, SL-145 potently suppressed tumor growth, angiogenesis, and metastases concomitant with dysregulation of the JAK2/STAT3 signaling pathway. Our findings highlight the potential of SL-145 in suppressing metastatic TNBC independent of the HSR.
Oligonucleotide Conjugates: Synthesis and Properties (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
N -Chloramines, a Promising Class of Well-Tolerated Topical Anti-Infectives (2013)

Antibiotic resistance is a growing public health crisis. To address the development of bacterial resistance, the use of antibiotics has to be minimized for nonsystemic applications in humans, as well as in animals and plants. Possible substitutes with low potential for developing resistance are active chlorine compounds that have been in clinical use for over 180 years. These agents are characterized by pronounced differences in their chlorinating and/or oxidizing activity, with hypochlorous acid (HOCl) as the strongest and organic chloramines as the weakest members. Bacterial killing in clinical practice is often associated with unwanted side effects such as chlorine consumption, tissue irritation, and pain, increasing proportionally with the chlorinating/oxidizing potency. Since the chloramines are able to effectively kill pathogens (bacteria, fungi, viruses, protozoa), their application as anti-infectives is advisable, all the more so as they exhibit additional beneficial properties such as destruction of toxins, degradation of biofilms, and anticoagulative and anti-inflammatory activities. Within the ample field of chloramines, the stable N-chloro derivatives of β-aminosulfonic acids are most therapeutically advanced. Being available as sodium salts, they distinguish themselves by good solubility and absence of smell. Important representatives are N-chlorotaurine, a natural compound occurring in the human immune system, and novel mono- and dichloro derivatives of dimethyltaurine, which feature improved stability.
Hydrogen-induced lattice expansion in a (001)-oriented Mo/V superlattice (1996)

The hydrogen-induced lattice expansion in a Mo/V single-crystal superlattice (${\mathit{L}}_{\mathrm{V}}$/${\mathit{L}}_{\mathrm{Mo}}$=2 nm/2 nm) has been studied by x-ray diffraction in the temperature range 20--500 \ifmmode^\circ\else\textdegree\fi{}C and hydrogen pressures ranging from 5--625 torr in a vacuum x-ray furnace. For temperatures between 350--500 \ifmmode^\circ\else\textdegree\fi{}C, the lattice expansion \ensuremath{\Delta}${\mathit{d}}_{\mathrm{V}}$/${\mathit{d}}_{\mathrm{V}}$ of the vanadium lattice in the growth direction of the superlattice was found to vary linearly with the hydrogen concentration, up to concentrations of H/V=0.5 (atomic ratio) with a slope of ${\mathit{k}}_{\mathit{s}}$=0.042(3). This value is almost a factor of 5 smaller than the bulk vanadium value of ${\mathit{k}}_{\mathit{b}}$=0.19(1). The reduced lattice expansion is shown to originate from the truncation of the in-plane stress components and the change in elastic response upon clamping. \textcopyright{} 1996 The American Physical Society.
Mutations in the alpha 2 helix of HLA-A2 affect presentation but do not inhibit binding of influenza virus matrix peptide. (1988)

Previous studies have suggested that MHC class I molecules bind and present peptides to CTL in a manner that is analogous to the presentation of peptides by class II molecules to Th. Crystallographic studies of HLA-A2 have led to the assignment of a putative peptide binding site that is bordered by two alpha helices consisting of residues 50-84 and 138-180. In this study, we have investigated whether residues in the alpha 2 helix are involved in the binding and/or presentation of a peptide to CTL. We have generated CTL to type A influenza virus by stimulation of human PBL with a synthetic peptide from the influenza A virus matrix protein (M1 residues 57-68) in the presence of rIL-2. Such HLA-A2.1-restricted influenza virus-immune CTL do not recognize infected HLA-A2.3+ targets. A2.1 and A2.3 differ by three amino acids in the alpha 2 domain: Ala vs. Thr at position 149, Val vs. Glu at position 152, and Leu vs. Trp at position 156. Site-directed mutants of the A2.1 gene that encode A2 molecules that resemble A2.3 at positions 149, 152, and 156 have been constructed, transfected into human cells, and assayed for their ability to present the M1 peptide. The results demonstrate that most, but not all, A2.1-restricted M1-peptide-specific CTL fail to recognize M1 peptide-exposed transfectants with certain single amino acid substitutions at positions 152 and 156. In contrast, M1 peptide-exposed transfectants that express A2 molecules with an Ala----Thr substitution at position 149 were recognized by all CTL tested, but they exhibited an apparent difference in the kinetics of peptide binding. These results indicate that amino acid substitutions at positions 152 and 156 of the putative peptide binding site of the A2 molecule can affect presentation without eliminating binding, and indicate that the failure to recognize complexes between the peptide and the mutant A2 molecules is due to different TCR specificities and not to the failure to bind the peptide.
Small-Cell Traffic Balancing Over Licensed and Unlicensed Bands (2015)

The Third-Generation Partnership Project (3GPP) has recently started standardizing the “licensed-assisted access using LTE” for small cells, which is referred to as dual-band femtocell (DBF) in this paper, which uses the Long-Term Evolution (LTE) air interface in both the licensed and unlicensed bands based on the LTE carrier aggregation feature. Alternatively, the Small Cell Forum introduced the integrated femto-WiFi (IFW) small cell, which simultaneously accesses both the licensed band (via cellular interface) and the unlicensed band (via WiFi interface). In this paper, a practical algorithm for IFW and DBF to automatically balance their traffic in licensed and unlicensed bands, based on the real-time channel, interference, and traffic conditions of both bands, is described. The algorithm considers the fact that some “smart” devices (sDevices) have both cellular and WiFi radios, while some WiFi-only devices (wDevices) may only have WiFi radio. In addition, the algorithm considers a realistic scenario where a single small-cell user may simultaneously use multiple sDevices and wDevices via either the IFW or the DBF in conjunction with a wireless local area network. The goal is to maximize the total user satisfaction/utility of the small-cell user, while keeping the interference from small cells to macrocells below predefined thresholds. The algorithm can be implemented at the radio link control or the network layer of the IFW and DBF small-cell base stations. Results demonstrate that the proposed traffic-balancing algorithm applied to either IFW or DBF significantly increases the sum utility of all macrocell and small-cell users, compared with the current practices. Finally, various implementation issues of IFW and DBF are addressed.
Ultrasound‐Supported Catalysis (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Synthesis of two dimensional quasi-aligned carbon nanotube bundles by a catalytic chemical vapour deposition method—an inside story (2004)

A simple and novel method was developed for efficient synthesis of 2D quasi-aligned multiwalled carbon nanotubes by a catalytic chemical vapour deposition technique. The CNT alignment and in depth analysis of structures has been studied by scanning electron microscopy and transmission electron microscopy. The growth rate and the purity of the product have been found to be affected by the flow rates of the gases as well as the nature of the support used.
Functional characterisation of decoy receptor 3 in Crohn’s disease (2008)

DcR3 may promote inflammation in Crohn's disease by inhibiting CD95L-induced apoptosis of epithelial and immune cells as well as by inducing NF-kappaB activation.
Hyperleptinemia is associated with impaired pulmonary host defense (2016)

We have previously reported that obesity attenuates pulmonary inflammation in both patients with acute respiratory distress syndrome (ARDS) and in mouse models of the disease. We hypothesized that obesity-associated hyperleptinemia, and not body mass per se, drives attenuation of the pulmonary inflammatory response and that this e_ect could also impair the host response to pneumonia. We examined the correlation between circulating leptin levels and risk, severity, and outcome of pneumonia in 2 patient cohorts (NHANES III and ARDSNet-ALVEOLI) and in mouse models of diet-induced obesity and lean hyperleptinemia. Plasma leptin levels in ambulatory subjects (NHANES) correlated positively with annual risk of respiratory infection independent of BMI. In patients with severe pneumonia resulting in ARDS (ARDSNet-ALVEOLI), plasma leptin levels were found to correlate positively with subsequent mortality. In obese mice with pneumonia, plasma leptin levels were associated with pneumonia severity, and in obese mice with sterile lung injury, leptin levels were inversely related to bronchoalveolar lavage neutrophilia, as well as to plasma IL-6 and G-CSF levels. These results were recapitulated in lean mice with experimentally induced hyperleptinemia. Our findings suggest that the association between obesity and elevated risk of pulmonary infection may be driven by hyperleptinemia.
34.1: Active Matrix Displays Made with Printed Polymer Thin Film Transistors (2003)

Abstract We present a process for active matrix flat panel display manufacture by printing polymer thin film transistors. In this process, transistors are fabricated using soluble semi‐conducting and conducting materials. Accurate definition of the transistor channel and other circuit components is achieved by direct inkjet printing combined with surface energy patterning. We have used this process to create a 4,800 pixel, 50 dpi, active matrix display. This process is in principle environmentally friendly, low temperature, compatible with flexible substrates, cost effective and advantageous for short run length and large display sizes.
Patient Specific Design and 3D Printing of Pediatric Implants and Devices (2017)

Presented on February 14, 2017 from 8:30 a.m.-9:30 a.m. at the Parker H. Petit Institute for Bioengineering and Bioscience (IBB), room 1128, Georgia Tech.
Phosphorothioate oligodeoxyribonucleotides dissociate from cationic lipids before entering the nucleus (1998)

Antisense oligonucleotides complementary to specific mRNA sequences are widely used inhibitors of gene expression in vitro and in vivo . In vitro cationic lipids have been demonstrated to increase the pharmacological activity of antisense oligonucleotides by increasing cellular uptake and facilitating nuclear accumulation. We have investigated the intracellular fate of oligonucleotide/cationic lipid complexes using fluorescently labeled lipids and oligonucleotides targeted to protein kinase C-alpha. After addition to cells the lipids initially co-localized with the oligonucleotide on the cell surface and in fine punctate structures within the cytoplasm. At later times the oligonucleotide began to accumulate in the nucleus as well as the cytoplasm. In contrast, the cationic lipid remained localized to the cell surface and the cytoplasm and was never found in the nucleus. Expression of protein kinase C-alpha mRNA did not begin to decline until after oligonucleotide was seen in the nucleus. This was also coincident with the transient appearance of a smaller mRNA transcript believed to result from RNase H cleavage of protein kinase C-alpha mRNA. These data suggest that although cationic lipids facilitate uptake of oligonucleotides, the complex must disassociate before the oligonucleotide can gain access to the nucleus and induce degradation of targeted mRNA.
Diagnostic reproducibility of the 2018 Classification of Gingival Recession Defects and Gingival Phenotype: A multicenter inter‐ and intra‐examiner agreement study (2022)

The 2018 Classification of Gingival Recession Defects and Gingival Phenotype is clinically reproducible within the examiners, and when the variables forming the matrix are analyzed individually. The between-examiner agreement for the complete matrix showed lower reproducibility. The agreement was highest for KTW and RD, and least for GT.
ChemInform Abstract: Rabbit Muscle Aldolase as a Catalyst in Organic Synthesis. (1989)

Abstract The title catalyst RAMA is synthetically useful for the stereoselective aldol condensation between aldehydes having a wide range of structures and dihydroxyacetone phosphate (II).
Mapping the Impact of Terrain on Lightning Incidence and Multiple Ground Contacts in Cloud-to-ground Flashes (2014)

The climatological incidence of cloud-to-ground (CG) lightning is known to have large regional differences associated synoptic-scale variations in weather that impact the development and propagation of deep convection. At smaller spatial scales, terrain variations are known to play a significant role in the development of deep convection leading to thunderstorms. Convective clouds frequently build over the high terrain typically beginning in the late morning or early afternoon, driven by mountain-valley circulations. In addition to the enhancement of deep convection in complex terrain, there are flash-scale interactions between downward propagating leaders and terrain variations that can alter the nature and location of attachment to ground. This suggests that there may be terrain-related variations in not only the incidence (ground flash density) of CG lightning and the location of the first flash in a storm, but also in some of the physical parameters of CG lightning flashes. The work presented here focuses on demonstrating the impact of terrain on the nature of multiple ground contacts in CG flashes using data provided by the U.S. National Lightning Detection Network during the period of 2006 through 2011. A method for classifying a CG stroke as creating a new ground contact or occurring in a pre-existing channel is presented first. This method employs information that can be provided by modern lightning locating systems. This tool is then used to study the spatial distribution of the average number of ground contacts per flash and the dominant spatial separation distances, in 5x5 degree regions with differing terrain variations. These data are analyzed at sub-km spatial scales using the DTED digital elevation model dataset.
The KDK (potassium decay) experiment (2017)

Potassium-40 (${}^{40}$K) is a background in many rare-event searches and may well play a role in interpreting results from the DAMA dark-matter search. The electron-capture decay of ${}^{40}$K to the ground state of ${}^{40}$Ar has never been measured and contributes an unknown amount of background. The KDK (potassium decay) collaboration will measure this branching ratio using a ${}^{40}$K source, an X-ray detector, and the Modular Total Absorption Spectrometer at Oak Ridge National Laboratory.
A High Association of Oncogenic Human Papillomaviruses with Carcinomas of the Female Urethra: Polymerase Chain Reaction-Based Analysis of Multiple Histological Types (1994)

Using polymerase chain reaction with type-specific human papillomavirus type 16 and 18 primers, and general primers screening for 9 other genotypes, we analyzed archival surgical specimens of urethral carcinoma from 18 women (17 with invasive cancer and 1 with carcinoma in situ). Human papillomavirus was detected in invasive urethral carcinoma specimens from 10 of 17 women (59%) and in the patient with carcinoma in situ. Human papillomavirus type 16 was found in 8 patients with invasive carcinoma (47%) and 1 with carcinoma in situ, and general primer polymerase chain reaction demonstrated human papillomavirus that could not be typed in 2 patients (12%). Type 16 was detected in metastases from 4 patients; complete concordance for the presence of human papillomavirus in primary and metastatic disease was noted. Eight of 10 women with squamous cell carcinoma and both with transitional cell carcinoma harbored human papillomavirus; 5 women with undifferentiated carcinoma or adenocarcinoma were all negative for human papillomavirus. Concurrently excised cervical tissue was available from 5 patients; 1 had cervical carcinoma in situ positive for human papillomavirus of the same type as the urethral carcinoma. These findings strongly suggest that human papillomavirus, particularly type 16, is associated with a substantial number of carcinomas of the female urethra but a stratification of specific histotypes associated with human papillomavirus may exist.
Structure/permeability relationships of polyimides with branched or extended diamine moieties (1993)

Abstract Mean permeability coefficients for CO 2 , O 2 , N 2 , and CH 4 in seven types of 6FDA polyimides with branched or extended diamine moieties were determined at 35.0°C (95.0°F) and at pressures up to 10.5 atm (155 psia). In addition, solubility coefficients for CO 2 , O 2 , N 2 , and CH 4 in six of these polyimides were determined at 35.0°C and at 6.8 atm (100 psia). Mean diffusion coefficients for the six gas/polyimide systems were calculated from the permeability and solubility data. The relationships between the chemical structure of the polyimides, some of their physical properties (glass transition temperature, mean interchain spacing, specific free volume), and their gas permeability, diffusivity, and solubility behavior are discussed. The 6FDA polyimides studied here exhibit a considerably lower selectivity for the CO 2 /CH 4 and O 2 /N 2 gas pairs than 6FDA polyimides with short and stiff aromatic diamines with comparable CO 2 and O 2 permeabilities. © 1993 John Wiley &amp; Sons, Inc.
Chemicofunctional Membrane for Integrated Chemical Processes on a Microchip (2002)

Here we report a design and synthesis of a chemically functional polymer membrane by an interfacial polycondensation reaction and multilayer flow inside a microchannel. Single and parallel dual-membrane structures are successfully prepared by using organic/aqueous two-layer flow and organic/aqueous/organic three-layer flow inside the microchannel followed by an interfacial polycondensation reaction. By using the inner-channel membrane, permeation of ammonia species through the inner-channel membrane is successfully achieved. Furthermore, horseradish peroxidase is immobilized on one side of the membrane surface to integrate the chemical transform function onto the inner-channel membrane. Here substrate permeation through the membrane and subsequent chemical transformation at the membrane surface are realized. The polymer membrane prepared inside the microchannel has an important role in ensuring stable contact of different phases such as gas/liquid or liquid/ liquid and the permeation of chemical species through the membrane. Furthermore, membrane surface modification chemistry allows chemical transformation of permeated chemical species. These methods are expected to lead to development of complicated and sophisticated chemical systems involving membrane permeation and chemical reactions.
The Rules of Redaction: Identify, Protect, Review (and Repeat) (2009)

Frequent data leak reports in the press attest to the difficulty of identifying and protecting sensitive content. Redaction is particularly challenging because it seeks to protect documents by selectively removing sensitive portions of them, rather than by quarantining or encrypting the whole document. The authors review current redaction practice and technology and describe a prototype system that supports the natural redaction workflow and addresses some limitations of current technology. Their system supports all phases of the redaction process through the use of linguistic content analysis, an interactive user interface, and inference detection algorithms.
Clozapine-induced eosinophilia and switch to quetiapine in a patient with chronic schizophrenia with suicidal tendencies. (2007)

Clozapine has proven effective in reducing morbidity and suicidality in chronic non-remitting patients with schizophrenia. Occasionally, despite good therapeutic response, clozapine must be stopped due to dangerous side effects such as agranulocytosis. Drug-induced eosinophilia is a non-dose-dependent side effect of clozapine. In cases of mild increments of eosinophils and if the patient is asymptomatic, there is no need to make an immediate decision. However, if the increment is severe and producing symptoms, withdrawing the probable causative drug is warranted. There is a possible association between eosinophilia and myocarditis, a life-threatening condition. The efficacy of corticosteroid therapy in the treatment of eosinophilia has not been clearly established. We present a case report where switching from clozapine to quetiapine maintained the improvement in clinical status, after remittance of eosinophilia.
Structural and electrochemical studies of novel Na₇V₃Al(P₂O₇)₄(PO₄) and Na₇V₂Al₂(P₂O₇)₄(PO₄) high-voltage cathode materials for Na-ion batteries (2017)

A series of Na₇V₄₋ₓ³⁺Alₓ(P₂O₇)₄(PO₄) (x = 0, 1, 2, and 4) materials were synthesized by flux crystal growth. Novel Na₇V₄₋ₓAlₓ(P₂O₇)₄(PO₄) (x = 1 and 2) compositions were structurally characterized by single crystal and powder X-ray diffraction analyses using laboratory and high-resolution synchrotron X-ray sources. The investigation of the electrochemical behavior of two new mixed V/Al phases as positive electrodes in Na-based batteries was performed using charge–discharge galvanostatic tests and operando X-ray diffraction experiments. It is demonstrated that the substitution of a part of vanadium with aluminum in Na₇V₄(P₂O₇)₄(PO₄) significantly increases the gravimetric capacity of these materials: from 70.9 mA h g⁻¹ to 113.1 mA h g⁻¹ and from 48.1 mA h g⁻¹ to 92.7 mA h g⁻¹ in Na₇V₃Al(P₂O₇)₄(PO₄) and Na₇V₂A₂l(P₂O₇)₄(PO₄), respectively thanks to the activation of the V⁴⁺/V⁵⁺ redox couple. Different degrees of reversibility of the electrochemical reactions operating on the V³⁺/V⁴⁺ and V⁴⁺/V⁵⁺ redox couples in Na₇V₃Al(P₂O₇)₄(PO₄) are discussed from the analysis of operando X-ray diffraction.