gebhart/patrepeval huggingface dataset:
Spindichteverteilung in freien Radikalen, V. Die Teilnahme des p‐ständigen Stickstoffatoms an der Phenoxyl‐Mesomerie (1966)

Abstract An 2.6‐Di‐tert.‐butyl‐phenoxylen ( 1a – 7a und 10a – 12a ) mit 4‐ständigem, Kern‐gebundenem Stickstoff wird gezeigt, daß das „odd”︁‐Elektron am N‐Atom eine endliche Spindichte besitzt. Sind an den Stickstoff geeignete Reste (X, Y) gebunden, dann läßt sich eine freie Spindichte auch in X und Y nachweisen. Im Falle der 4‐Dialkyl‐amino‐ bzw. 4‐Diaryl‐amino‐2.6‐ditert.‐butyl‐phenoxyle wird die freie Spindichte an den meta ‐Ringkohlenstoffatomen sehr klein. Dies kann durch die Annahme einer stärkeren Lokalisierung des freien Elektrons am N‐Atom (Betain‐Struktur) gedeutet werden.
Predicting respiratory instability in the ICU (2008)

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) contribute to the morbidity and mortality of intensive care patients worldwide, and have large associated human and financial costs. We identified a reference data set of 624 mechanically-ventilated patients in the MIMIC-II intensive care database with and without low PaO(2)/FiO(2) ratios (termed respiratory instability), and developed prediction algorithms for distinguishing these patients prior to the critical event. In the end, we had four rule sets using mean airway pressure, plateau pressure, total respiratory rate and oxygen saturation (SpO(2)), where the specificity/sensitivity rates were either 80%/60% or 90%/50%.
Performance of a Natural Gas Solid Oxide Fuel Cell System With and Without Carbon Capture (2019)

Abstract The fuel cell program at the United States Department of Energy (DOE) National Energy Technology Laboratory (NETL) is focused on the development of low-cost, highly efficient, and reliable fossil-fuel-based solid oxide fuel cell (SOFC) power systems that can generate environmentally-friendly electric power with at least 90 percent carbon capture. NETL’s SOFC technology development roadmap is aligned with near-term market opportunities in the distributed generation sector to validate and advance the technology while paving the way for utility-scale natural gas (NG)- and coal-derived synthesis gas-fueled applications via progressively larger system demonstrations. The present study represents a part of a series of system evaluations being carried out at NETL to aid in prioritizing technological advances along research pathways to the realization of utility-scale SOFC systems, a transformational goal of the fuel cell program. In particular, the system performance of utility-scale NG fuel cell (NGFC) systems with and without carbon dioxide (CO2) capture is presented. The NGFC system analyzed features an external auto-thermal reformer (ATR) feeding the fuel to the SOFC system consisting of planar anode-supported SOFC with separated anode and cathode off-gas streams. In systems with CO2 capture, an air separation unit (ASU) is used to provide the oxygen for the ATR and for the combustion of unutilized fuel in the SOFC anode exhaust along with a CO2 purification unit to provide a nearly pure CO2 stream suitable for transport for usage in enhanced oil recovery operations or for storage in underground saline formations. Remaining thermal energy in the exhaust gases is recovered in a bottoming steam Rankine cycle while supplying any process heat requirements. A reduced order model (ROM) developed at the Pacific Northwest National Laboratory (PNNL) is used to predict the SOFC performance. The ROM, while being computationally effective for system studies, provides other detailed information about the state of the stack, such as the internal temperature gradient, generally not available from simple performance models often used to represent the SOFC. Such additional information can be important in system optimization studies to preclude operation under off-design conditions that can adversely impact overall system reliability. The NGFC system performance was analyzed by varying salient system parameters, including the percent of internal (to the SOFC module) NG reformation — ranging from 0 to 100 percent — fuel utilization, and current density. The impact of advances in underlying SOFC technology on electrical performance was also explored.
Synthesis and Processing of the Haemagglutinin--esterase Glycoprotein of Bovine Coronavirus Encoded in the E3 Region of Adenovirus (1992)

The haemagglutinin-esterase gene (HE) of bovine coronavirus (BCV) encodes a major viral membrane glycoprotein that elicits BCV-neutralizing antibodies. The BCV HE gene was cloned into a human adenovirus serotype 5 (Ad5) transfer vector in place of early transcription region 3, and a helper-independent recombinant virus was constructed by rescue of the transcription unit by homologous in vivo recombination between the vector and Ad5 genomic DNA. The BCV HE polypeptide expressed by this recombinant Ad was characterized in vivo and in vitro. A 65K polypeptide was identified using an anti-BCV antibody in both human (293) and bovine (MDBK) cells infected with the recombinant Ad. In the absence of a reducing agent, migration of the 65K polypeptide was shifted to 130K, indicating that the recombinant HE polypeptide existed in a dimeric form. The HE polypeptide was glycosylated, as demonstrated by labelling with [3H]glucosamine, and was immunoreactive with three distinct groups of conformation-specific anti-HE monoclonal antibodies (MAbs). Cells infected with recombinant Ad expressing BCV HE exhibited both haemadsorption activity and acetylesterase activity. In addition, the anti-HE group A MAbs HC10-5 and KD9-40 inhibited both the haemadsorption activity and esterase activity of the recombinant HE polypeptide, suggesting that the antigenic domain responsible for BCV neutralization may overlap (or is closely associated with) the domain(s) responsible for haemagglutination and/or acetylesterase activities. When mice were inoculated intraperitoneally with live recombinant Ad, a significant level of BCV-neutralizing HE-specific antibody was induced. These results indicate that the recombinant Ad replicates and directs the synthesis of the BCV HE polypeptide in vivo.
Depth and range shifting of a focal spot using a time-reversal mirror in an acoustic waveguide (2002)

We present a technique based on time reversal to focus an acoustic field at any depth and range in a waveguide. We take advantage of the signal received from an acoustic beacon in the guide to build a time-reversed modified version of the field that refocuses at a different point in the waveguide. This method is based on the application of the images theorem in the guide and, as in the classical time-reversal experiment, it does not require a priori knowledge of the waveguide characteristics. Ultrasonic laboratory experiments and underwater acoustic simulations are presented and compared to classical time-reversal focusing results.
A Clinical Photographic Method to Evaluate the Need for Helmet Therapy in Deformational Plagiocephaly (2017)

Since cast helmet manufacturing for positional plagiocephaly therapy does not require computed tomography scanning, there is no need to administer a sedative, nor does it pose any radiation exposure risk. Since the cast helmet is easier to manufacture and operate and is more cost effective, it could be used to treat more people. In addition, it would be useful for both medical professionals and patients' guardians to use clinical photographs with the acrylic sheet with the grid as a method to analyze shapes and outcomes before and after therapy, along with traditional CVA and CVAI.
Chorus: Collision Resolution for Efficient Wireless Broadcast (2010)

Traditional wireless broadcast protocols rely heavily on the 802.11-based CSMA/CA model, which avoids interference and collision by conservatively scheduling transmissions. While CSMA/CA is amenable to multiple concurrent unicasts, it tends to degrade broadcast performance, especially when there are a large number of nodes and links are lossy. In this paper, we propose a new, drastically different protocol called Chorus that improves the efficiency and scalability of broadcast service with a MAC layer that allows packet collisions. Chorus is built upon the observation that packets carrying the same data can be effectively detected and decoded, even when they overlap in time and have comparable signal strength. It performs collision resolution using symbol-level iterative decoding, and then combines the resolved symbols to reconstruct the packet. This collision-tolerant mechanism significantly improves the transmission diversity and spatial reuse in wireless broadcast, providing an asymptotic broadcast delay that is proportional to the network radius. This advantage is exploited further by Chorus's MAC-layer cognitive sensing and scheduling scheme. We evaluate Chorus with symbol-level simulation, and validate its network-level performance via ns-2, in comparison with a typical CSMA/CA broadcast protocol.
Synthesis, Characterization, and Morphology of Poly(tert-butyl vinyl ether-b-isobutylene-b-tert-butyl vinyl ether) Triblock Copolymers (2004)

The living cationic sequential block copolymerization of isobutylene (IB) with tert-butyl vinyl ether (tBVE) was studied using a one-pot procedure in hexanes/CH2Cl2 and hexanes/CH3Cl solvent systems at −80 °C. It was carried out by the so-called capping-tuning technique, involving the capping of living PIB chain ends with 1,1-ditolylethylene (DTE) followed by addition of titanium(IV) isopropoxide (Ti(OIp)4) to lower the Lewis acidity before the introduction of tBVE. Homopolymerizations/model block copolymerizations of tBVE were carried out using 2-chloro-2,4,4-trimethylpentane (TMPCl) instead of living PIB. The living nature was exhibited by the linear plots of ln([M]0/[M]) vs time and number average molecular weight (Mn) vs conversion. 13C NMR spectroscopy indicated that the PtBVE is highly isotactic with close to 80% meso dyads. Well-defined PIB-b-PtBVE diblock copolymers were synthesized by the living cationic polymerization of IB followed by capping the living PIB ends with DTE and fine-tuning the Lewis acidity to obtain 100% crossover efficiency and a desired tBVE polymerization rate. While both hexanes/CH2Cl2 and hexanes/CH3Cl solvent systems could be used, the polymerization was better controlled and the product exhibited narrower molecular weight distribution (MWD) in hexanes/CH3Cl solvent mixtures. Well-defined triblock copolymers with close to designed molecular weights and narrow MWDs (<1.1) were prepared using 5-tert-butyl-1,3-bis(1-chloro-1-methylethyl)benzene (tBuDiCumCl) as a difunctional initiator. Differential scanning calorimetry (DSC) of the block copolymers showed two glass transitions demonstrating microphase separation. The triblock copolymers with 23−39 wt % PtBVE content exhibited typical characteristics of a thermoplastic elastomer (TPE) with tensile strengths of 9−15 MPa and elongations at break of 760−1300%. Morphological studies by transmission electron microscopy (TEM), small-angle X-ray scattering (SAXS), and atomic force microscopy (AFM) revealed lamellar or cylindrical morphologies of the triblock copolymers, depending on their molecular compositions.
Non-Orthogonal Physical Layer (NOPHY) Design towards 5G Evolution and 6G (2022)

5G has achieved large-scale commercialization across the world and the global 6G research and development is accelerating. To support more new use cases, 6G mobile communication systems should satisfy extreme performance requirements far beyond 5G. The physical layer key technologies are the basis of the evolution of mobile communication systems of each generation, among which three key technologies, i.e., duplex, waveform and multiple access, are the iconic characteristics of mobile communication systems of each generation. In this paper, we systematically review the development history and trend of the three key technologies and define the Non-Orthogonal Physical Layer (NOPHY) concept for 6G, including Non-Orthogonal Duplex (NOD), Non-Orthogonal Multiple Access (NOMA) and Non-Orthogonal Waveform (NOW). Firstly, we analyze the necessity and feasibility of NOPHY from the perspective of capacity gain and implementation complexity. Then we discuss the recent progress of NOD, NOMA and NOW, and highlight several candidate technologies and their potential performance gain. Finally, combined with the new trend of 6G, we put forward a unified physical layer design based on NOPHY that well balances performance against flexibility, and point out the possible direction for the research and development of 6G physical layer key technologies.
Acoustic intensity calculations for axisymmetrically modeled fluid regions (1992)

An algorithm for calculating acoustic intensities from a time harmonic pressure field in an axisymmetric fluid region is presented. Acoustic pressures are computed in a mesh of NASTRAN triangular finite elements of revolution (TRIAAX) using an analogy between the scalar wave equation and elasticity equations. Acoustic intensities are then calculated from pressures and pressure derivatives taken over the mesh of TRIAAX elements. Intensities are displayed as vectors indicating the directions and magnitudes of energy flow at all mesh points in the acoustic field. A prolate spheroidal shell is modeled with axisymmetric shell elements (CONEAX) and submerged in a fluid region of TRIAAX elements. The model is analyzed to illustrate the acoustic intensity method and the usefulness of energy flow paths in the understanding of the response of fluid-structure interaction problems. The structural-acoustic analogy used is summarized for completeness. This study uncovered a NASTRAN limitation involving numerical precision issues in the CONEAX stiffness calculation causing large errors in the system matrices for nearly cylindrical cones.
DNA sequence dependent binding modes of 4',6-diamidino-2-phenylindole (DAPI) (1990)

The interactions of DAPI with natural DNA and synthetic polymers have been investigated by hydrodynamic, DNase I footprinting, spectroscopic, binding, and kinetic methods. Footprinting results at low ratios (compound to base pair) are similar for DAPI and distamycin. At high ratios, however, GC regions are blocked from enzyme cleavage by DAPI but not by distamycin. Both poly[d(G-C)]2 and poly[d(A-T)]2 induce hypochromism and shifts of the DAPI absorption band to longer wavelengths, but the effects are larger with the GC polymer. NMR shifts of DAPI protons in the presence of excess AT and GC polymers are significantly different, upfield for GC and mixed small shifts for AT. The dissociation rate constants and effects of salt concentration on the rate constants are also quite different for the AT and the GC polymer complexes. The DAPI dissociation rate constant is larger with the GC polymer but is less sensitive to changes in salt concentration than with the AT complex. Binding of DAPI to the GC polymer and to poly[d(A-C)].poly[d(G-T)] exhibits slight negative cooperativity, characteristic of a neighbor-exclusion binding mode. DAPI binding to the AT polymer is unusually strong and exhibits significant positive cooperativity. DAPI has very different effects on the bleomycin-catalyzed cleavage of the AT and GC polymers, a strong inhibition with the AT polymer but enhanced cleavage with the GC polymer. All of these results are consistent with two totally different DNA binding modes for DAPI in regions containing consecutive AT base pairs versus regions containing GC or mixed GC and AT base pair sequences. The binding mode at AT sites has characteristics which are similar to those of the distamycin-AT complex, and all results are consistent with a cooperative, very strong minor groove binding mode. In GC and mixed-sequence regions the results are very similar to those observed with classical intercalators such as ethidium and indicate that DAPI intercalates in DNA sequences which do not contain at least three consecutive AT base pairs.
An Interplay between Chemical Reaction of Fine Particles and Rheology of Disperse Systems (1998)

Problems spanning the boarder across the suspension rheology and fine particles reaction are discussed. Three case studies are given with regard to the change in the rheological behavior of concentrated suspension due to chemical reactions: (1) change in the aggregation morphology in the silica/silica sol suspension on aging, (2) influence of the in situ surface precipitation of indiumtin solid solution on the surface of indium oxide, and (3) effects of surface scratching and aging of soda lime glass particles on the electrorheological properties of their dispersions.
Dominant CD8+T-Lymphocyte Responses Suppress Expansion of Vaccine-Elicited Subdominant T Lymphocytes in Rhesus Monkeys Challenged with Pathogenic Simian-Human Immunodeficiency Virus (2009)

Emerging data suggest that a cytotoxic T-lymphocyte response against a diversity of epitopes confers greater protection against a human immunodeficiency virus/simian immunodeficiency virus infection than does a more focused response. To facilitate the creation of vaccine strategies that will generate cellular immune responses with the greatest breadth, it will be important to understand the mechanisms employed by the immune response to regulate the relative magnitudes of dominant and nondominant epitope-specific cellular immune responses. In this study, we generated dominant Gag p11C- and subdominant Env p41A-specific CD8(+) T-lymphocyte responses in Mamu-A*01(+) rhesus monkeys through vaccination with plasmid DNA and recombinant adenovirus encoding simian-human immunodeficiency virus (SHIV) proteins. Infection of vaccinated Mamu-A*01(+) rhesus monkeys with a SHIV Gag Deltap11C mutant virus generated a significantly increased expansion of the Env p41A-specific CD8(+) T-lymphocyte response in the absence of secondary Gag p11C-specific CD8(+) T-lymphocyte responses. These results indicate that the presence of the Gag p11C-specific CD8(+) T-lymphocyte response following virus challenge may exert suppressive effects on primed Env p41A-specific CD8(+) T-lymphocyte responses. These findings suggest that immunodomination exerted by dominant responses during SHIV infection may diminish the breadth of recall responses primed during vaccination.
A 25 mW smart CMOS wind sensor with corner heaters (2015)

A smart CMOS thermal wind sensor has been optimized for commercial use. Optimizing the sensor chip's thermal design resulted in better area efficiency and improved thermal dynamics with respect to prior work. The latter simplifies the off-chip decimation of the sensor's bitstream outputs. Moreover, by realizing more logic on-chip, the number of bond wires has been reduced by 33%, to 8, thus reducing manufacturing costs. Fabricated in a standard 0.7μm CMOS process, the sensor chip occupies 4×4mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and consumes 25mW of heating power, while achieving an inaccuracy of ±6% (speed) and ±2° (direction), for wind speeds between 4 and 25m/s.
Peptide Sequence Analysis by Electron Transfer Dissociation Mass Spectrometry: A Web-Based Tutorial (2015)

We created a web-based tutorial designed to teach manual interpretation and identification of spectra acquired using electron transfer dissociation (ETD). The tutorial provides an explanation of the ETD fragmentation process with the goal of identifying all of the significant peaks in a spectrum. We discuss determination of the precursor mass and charge state, neutral losses, electron transfer without dissociation (ETnoD), and the mechanisms by which fragment ions are created. Our hope is to provide a tool that presents the information already taught in D.F.H.'s short courses in a way that is easy for any student or researcher in the mass spectrometry community to access. The tutorial may be found at http://www.huntlab.org.
High Prevalence of Claudin 18.2 Expression in Japanese Patients with Gastric Cancer. (2017)

e15584 Background: Expression of the gastric mucosal tight junction protein, Claudin-18.2 (CLDN18.2), is altered in gastric cancer (GC). In a phase 2 clinical trial (NCT01630083; FAST), a monoclonal antibody against CLDN18.2 (IMAB362) significantly increased overall survival in European patients with CLDN18.2-positive (CLDN18.2 + ) gastric and gastroesophageal junction adenocarcinomas when added to an EOX chemotherapy regimen. As the GC occurrence is high in Japan, this study evaluated the prevalence of CLDN18.2 expression in Japanese patients with GC. Methods: CLDN18.2 expression was assessed in primary GC tumors and corresponding lymph node metastases (LNM) by cell membrane staining intensity using a validated, semi-quantitative, immunohistochemical assay for CLDN18.2 expression. Samples showing any positivity for specific staining with at least 1+ intensity were defined as CLDN18.2 + . Correlation between percentage of CLDN18.2 + cells in primary tumors and corresponding LNM was determined with Spearman’s rank correlation. Results: A total of 263 samples, including tissues from 134 primary GC tumor/LNM matched pairs, 128 primary GC tumors only, and 1 LNM only were collected at Kurume University Medical Center, Japan, between 2000 and 2012. Overall, CLDN18.2 was detected in 87% (n = 228/262) of all primary tumors and 80% (n = 108/135) of LNM. Strong CLDN18.2 expression (≥2+ membrane staining intensity in ≥40% of tumor cells; eligibility criterion in FAST) was observed in 52% (n = 135/262) of primary tumors and 45% (n = 61/135) of LNM. Individual tumor samples consisted of a mixture of tumor cells expressing CLDN18.2 at different staining intensities; samples with a high fraction of CLDN18.2 reactivity had a large proportion of tumor cells staining with 3+ intensity (Spearman r = .8413, P&lt; .0001). In matched pairs, 72% of samples were CLDN18.2 + (n = 96/134) and 9% were CLDN18.2 – (n = 12/134). The fraction of CLDN18.2 + tumor cells at any staining intensity strongly correlated in matched paired samples (Spearman r = .6942; P&lt; .0001). Conclusions: CLDN18.2 expression is highly prevalent in Japanese GC patients, making it a targetable alteration and supporting development of IMAB362 as a therapeutic agent for this patient population.
Biodegradation of Poly(alkylcyanoacrylates) (2002)

Abstract Introduction Historical Outline Synthesis and Purification of Alkylcyanoacrylate Monomers Polymer Synthesis General Considerations Bulk Polymerization Polymerization in Organic Solvents Emulsion Polymerization: Preparation of Matricial PACA Nanoparticles (Nanospheres) Interfacial Polymerization: Preparation of Reservoir‐Type PACA Nanoparticles (Nanocapsules) Synthesis of Amphiphilic Block Copolymers Containing PACA Segments World Market Characterization and Methods of Analysis Stability and Mechanism of Degradation Toxicity Application of PACA in the Design of Drug Delivery Systems Use of “Conventional” PACA Nanoparticles From “Conventional” to Targeted Systems Patent Overview Outlook and Perspectives
Transcriptome analysis in blastocyst hatching by cDNA microarray* (2005)

This work provides important information for studying the mechanisms of blastocyst hatching and implantation. These hatching-specific genes may have potential as new drug targets for controlling fertility.
Microstructure of Co–Al–O granular thin films (1997)

We have investigated the microstructures of Co–Al–O granular thin films, which were prepared by the sputter-deposition technique with various oxygen partial pressures. The constituent phases, grain sizes of granular particles, and width of insulating channels have been evaluated quantitatively. The specimen with the optimum giant magnetoresistance (GMR) is composed of nanoscale Co particles, and these are completely isolated by amorphous aluminum oxide channels. The GMR behavior observed in the Co–Al–O films has a close correlation with the width of the insulating channel and the grain size of the magnetic particles, which is consistent with the spin-dependent tunneling conduction mechanism of GMR