gebhart/patrepeval huggingface dataset:
Different clinical features in monozygotic twins: a case of 7q — syndrome (1993)

We present male monozygotic twins who showed quite different clinical features. Blood chromosome analysis revealed 46,XY/46,XY,del(7) (q32-->qter) mosaicism in both twins. However, cultured skin fibroblasts from the twins showed different karyotypes. Twin 1, with a normal phenotype, had normal chromosomes and was 46,XY. Twin 2, on the other hand, had the characteristic manifestations of 7q- syndrome and chromosomes of 46,XY,del(7) (q32-->qter). DNA fingerprint analysis of their peripheral blood samples revealed the same pattern. However, DNA fingerprint patterns of cultured skin fibroblasts and buccal mucosal cells were different when a 7q terminal marker, probe g3, was used. These identical twins with discordant phenotypes can be explained by the occurrence of twinning and simultaneous erroneous mitosis. In addition, there might be a vascular communication which probably resulted in blood exchange and chromosomal mosaicism of the lymphocytes of the monozygotic twins.
Applications of Traveling-Wave Electroabsorption Modulators in 160 Gbit/s Systems (2004)

Abstract We review applications of traveling-wave electroabsorption modulators for OTDM gating operations and clock-recovery. It is shown that traveling-wave electrodes can provide an extra degree of freedom in the optimisation and application of the electroabsorption modulator.
Modeling SARS-CoV-2 infection in individuals with opioid use disorder with brain organoids (2021)

The COVID-19 pandemic has aggravated a preexisting epidemic: the opioid crisis. Much literature has shown that the circumstances imposed by COVID-19, such as social distancing regulations, medical and financial instability, and increased mental health issues, have been detrimental to those with opioid use disorder (OUD). In addition, unexpected neurological sequelae in COVID-19 patients suggest that COVID-19 compromises neuroimmunity, induces hypoxia, and causes respiratory depression, provoking similar effects as those caused by opioid exposure. Combined conditions of COVID-19 and OUD could lead to exacerbated complications. With limited human in vivo options to study these complications, we suggest that iPSC-derived brain organoid models may serve as a useful platform to investigate the physiological connection between COVID-19 and OUD. This mini-review highlights the advances of brain organoids in other neuropsychiatric and infectious diseases and suggests their potential utility for investigating OUD and COVID-19, respectively.
Inhibition of Chk1 by the G[subscript 2] DNA damage checkpoint inhibitor isogranulatimide (2008)

Inhibitors of the G{sub 2} DNA damage checkpoint can selectively sensitize cancer cells with mutated p53 to killing by DNA-damaging agents. Isogranulatimide is a G{sub 2} checkpoint inhibitor containing a unique indole/maleimide/imidazole skeleton identified in a phenotypic cell-based screen; however, the mechanism of action of isogranulatimide is unknown. Using natural and synthetic isogranulatimide analogues, we show that the imide nitrogen and a basic nitrogen at position 14 or 15 in the imidazole ring are important for checkpoint inhibition. Isogranulatimide shows structural resemblance to the aglycon of UCN-01, a potent bisindolemaleimide inhibitor of protein kinase C{beta} (IC{sub 50}, 0.001 micromol/L) and of the checkpoint kinase Chk1 (IC{sub 50}, 0.007 micromol/L). In vitro kinase assays show that isogranulatimide inhibits Chk1 (IC{sub 50}, 0.1 {micro}mol/L) but not protein kinase C{beta}. Of 13 additional protein kinases tested, isogranulatimide significantly inhibits only glycogen synthase kinase-3{beta} (IC{sub 50}, 0.5 {micro}mol/L). We determined the crystal structure of the Chk1 catalytic domain complexed with isogranulatimide. Like UCN-01, isogranulatimide binds in the ATP-binding pocket of Chk1 and hydrogen bonds with the backbone carbonyl oxygen of Glu{sup 85} and the amide nitrogen of Cys{sup 87}. Unlike UCN-01, the basic N15 of isogranulatimide interacts with Glu{sub 17}, causing a conformation change more » in the kinase glycine-rich loop that may contribute importantly to inhibition. The mechanism by which isogranulatimide inhibits Chk1 and its favorable kinase selectivity profile make it a promising candidate for modulating checkpoint responses in tumors for therapeutic benefit. « less
Diversity of genes involved in the metabolism of gallic acid, a dietary component, within the human gut microbiota (2018)

Póster presentado al 7th International Human Microbioime Consortium Meeting (IHMC), celebrado en Killarney (Irlanda) del 26 al 28 de junio de 2018.
Biodistribution Study of Doxorubicin Encapsulated in Liposomes: Influence of Peptide Coating and Lipid Composition (2004)

In this paper we describe the biodistribution of doxorubicin (DXR) encapsulated in three different types of liposomes. Common composition was hydrogenated phosphatidylcholine (HPC)/phosphatidylglycerol (PG) cholesterol (Chol)/X, X being either 10% N-glutaryl phosphatidylethanolamine (NGPE), 10% NGPE + 6% distearoyl-phosphatidylethanolamine-polyethyleneglycol 2000 (DSPE-PEG), or 10% NGPE + 6% DSPE-PEG-COOH. These series of vesicles were coated with an active or an inactive sequence of laminin (laminin receptors, integrins, are overexpressed in tumor cells). Single doses of these preparations were injected, i.v., into healthy mice. For biodistribution experiments, mice were sacrificed at three different time-points post-treatment. Doxorubicin and doxorubicinol (DXOH) levels were determined in plasma, heart, lung, kidney, spleen, and liver using HPLC with daunorubicin (DNR) as internal standard. The results obtained indicate that compositions containing DSPE-PEG have the longest half-lives in plasma, as was to be expected according to the data in the literature. However, the presence of the peptides on the surface of liposomes reduces concentration values in this tissue. Distribution in other organs reveals high differences, among the liposomal samples studied, depending mainly on the presence of active or inactive peptide on the surface of vesicles. Liposomes coated with the laminin active sequence show lower accumulation in studied tissues than free DXR. This indicates that heart toxicity, associated to DXR treatments, could be diminished, and open promising perspectives for its future study in tumor-bearing animals.
Predicting Solid–Liquid Equilibrium of Fatty Acid Methyl Ester and Monoglyceride Mixtures as Biodiesel Model Fuels (2017)

Abstract Fatty acid methyl esters from plant oils are the main component of biodiesel and used as a substitute for petroleum diesel. Biodiesel generally contains a small amount of monoglycerides as intermediate compounds, which have high melting points and often solidify and clog fuel filters. The prediction of the cold‐flow property of biodiesel is of great importance for practical application. In this study, a thermodynamic study was conducted for mixtures of monoglycerides and fatty acid methyl esters. Temperatures of the solid–liquid equilibrium for the mixtures were measured by differential scanning calorimetry and visual observation, while the theoretical values were calculated using the modified Universal Quasi‐chemical Functional‐group Activity Coefficients (UNIFAC) model (Dortmund). The theoretical and experimental results were in good agreement, especially for binary mixtures of monoglycerides and methyl esters. The importance of monoglycerides on the cold‐flow properties of biodiesel was determined, and the effects could be well described by the modified UNIFAC model (Dortmund).
Trusty or Rusty? Oxidation Rate of Nails (2005)

In this Activity, students investigate the process of rusting using supermarket chemicals: unflavored gelatin, table salt and backache pain reliever tablets. A gelatin mixture is prepared and steel nails are placed in the gelatin and allowed to react with atmospheric oxygen. Ferric ion produced by the oxidation is made visible as a garnet-colored complex by magnesium salicylate present in the backache tablets. Factors that accelerate or retard the rate of iron oxidation are studied.
Broad-band continuous-wave four-wave mixing in silicon wire waveguides (2007)

We demonstrate continuous-wave four-wave mixing over an extremely broad bandwidth using dispersion-engineered silicon nanowaveguides, which allow for efficient wavelength conversion across four telecommunication bands from 1477 nm to 1672 nm.
Current regulator instabilities on parallel voltage source inverters (2002)

Parallel inverters are often used to meet system power requirements beyond the capacity of the largest single structure. They have also been used to reduce harmonics, reduce PWM switching frequency and increase available output voltage or frequency. The type of parallel structure depends on the construction of the load motor; the most prevalent are dual three-phase machines, split-phase machines, six-phase machines and a standard three-phase machine with interphase reactors. Operation of parallel structures presents areas for investigation encompassing analysis, simulation, control and design. The paper reports on the commissioning of a 775 hp dual winding three-phase motor with parallel inverters. A simple method of paralleling structures with carrier-based PWM current regulators (CRPWM) to independently regulate each inverter's current is employed. Experimental results show a loss of current control that is similar to a random event. The instability between the parallel inverters and the common motor can result in large uncontrolled currents. Simulations established the reduction in controller gain, as the regulator enters the PWM pulse dropping or overmodulation region, results in a loss of current control. Experimental results show the loss of current control is the result of an interaction between the parallel inverters through the dual wound three-phase motor. Modifications were made to the modulator and a two-phase discontinuous controller employed; the gain characteristic of the two-phase modulator in the overmodulation region extends over the dynamic range of the motor drive.
COMPARISON OF THERMAL CONDUCTIVITIES ON ABRADED AND UNTREATED CVD-DIAMOND OBTAINED BY SCANNING THERMAL MICROSCOPY (2002)

Diamond materials have become progressively significant in the fabrication of heat sinks for power devices and lasers. To investigate the influence of polishing on CVD-Diamond, the surfaces of &lt;100&gt; and &lt;110&gt; coatings were analyzed, after a first abrasive treatment on a 30μm diamond grit by scanning thermal microscopy based on a resistive platinum-probe. This technique describes in first order approximation the heat transfer of a metal-diamond interface. Through this method it was possible to diagnose a relevant reduction in thermal conductivity by a harsh sample preparation depending on the crystal orientation. The thermal conductivity of as deposited &lt;100&gt; diamond was measured at 1290 W/mK and was reduced to 250 W/mK. The thermal conductivity of as deposited &lt;110&gt; diamond was determined at 1780 W/mK whereas the same diamond surface, but abraded, shows a thermal conductivity of just 460 W/mK. Additionally the received images which represents the thermal conductivity qualitatively bring forward micro structures like e.g. grain boundaries.
Relay Selection for Buffer-Aided Non-Orthogonal Multiple Access Networks (2017)

Non-Orthogonal Multiple Access (NOMA) has the potential to increase the spectral efficiency of fifth generation (5G) networks by allowing simultaneous transmission to/from multiple users in the same wireless channel. In this work, a Buffer-Aided (BA) NOMA multiple relay network is considered, where the source transmits with fixed rate towards two users. By adopting BA relays, increased robustness can be achieved, as additional degrees of freedom are provided to relay selection. In order to increase the diversity of NOMA transmissions, two BA Half-Duplex (HD) relay selection algorithms are developed, considering the required transmission rate for each user, for Successive Interference Cancellation (SIC) at the reception and the Buffer State Information (BSI) at the relays. Then, results are provided in terms of outage probability, average throughput and average delay for the two algorithms. Finally, conclusions and possible future directions are given.
PET/MRI of metabolic activity in osteoarthritis: A feasibility study (2016)

2 Technical Efficacy: Stage 1 J. MAGN. RESON. IMAGING 2017;45:1736-1745.
An Inverse Relation Between COX-2 and E-cadherin Expression Correlates With Aggressive Histologic Features in Prostate Cancer (2006)

The identification of biomarkers in prostatic carcinoma has yielded important data regarding prognosis and has aided in increasing diagnostic accuracy. Additionally, this approach has yielded important insights into the biology of prostatic carcinoma. In this study, we report that the expression of the cyclooxygenase isoenzyme, COX-2, is significantly increased in prostatic carcinoma, whereas that of the cell adhesion molecule, E-cadherin, is decreased. The expression of COX-2 was positively correlated with higher tumor stage, and the presence of carcinoma in surgical margins at prostatectomy. Conversely, the expression of E-cadherin was inversely related to these prognostic indicators. Lastly, the expressions of COX-2 and E-cadherin were very strongly and inversely correlated. These results provide important insights into the biologic underpinnings of prostate carcinoma; and further studies into COX-2 expression in prostate core biopsies may show utility in preprostatectomy prognostication. Furthermore, these results may provide a rational basis for therapeutic intervention and chemoprevention with COX-2 inhibitor therapy in prostate carcinoma.
Apparatus and method for the determination of grain size in thin films (2023)

A method for the determination of grain size in a thin film sample comprising the steps of measuring first and second changes in the optical response of the thin film, comparing the first and second changes to find the attenuation of a propagating disturbance in the film and associating the attenuation of the disturbance to the grain size of the film. The second change in optical response is time delayed from the first change in optical response.
Revealing Local Field Structure of Focused Ultrashort Pulses (2011)

We utilize the interaction of tightly focused ultrashort pulses with transparent media to imprint their local polarization in the focal region. In particular, we demonstrate that this technique allows for a subwavelength resolution diagnostic of complex polarization states including the presence of the longitudinal component of the electric field. Moreover, we demonstrate the first ever material ablation with the longitudinal electric field of femtosecond pulses.
Complexity Reduction of Perturbation-based Nonlinear Compensator by Sub-band Processing (2015)

We propose and numerically evaluate a novel sub-band processing architecture for computational complexity reduction of the perturbation-based nonlinear compensator. The complexity is reduced by a factor of 12.4 in 3000-km transmission with 0.1 dB penalty.
Research Agenda for Frailty in Older Adults: Toward a Better Understanding of Physiology and Etiology: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults (2006)

Evolving definitions of frailty, and improved understanding of molecular and physiological declines in multiple systems that may increase vulnerability in frail, older adults has encouraged investigators from many disciplines to contribute to this emerging field of research. This article reports on the results of the 2004 American Geriatrics Society/National Institute on Aging conference on a Research Agenda on Frailty in Older Adults, which brought together a diverse group of clinical and basic scientists to encourage further investigation in this area. This conference was primarily focused on physical and physiological aspects of frailty. Although social and psychological aspects of frailty are critically important and merit future research, these topics were largely beyond the scope of this meeting. Included in this article are sections on the evolving conceptualization and definitions of frailty; physiological underpinnings of frailty, including the potential contributions of inflammatory, endocrine, skeletal muscle, and neurologic system changes; potential molecular and genetic contributors; proposed animal models; and integrative, system biology approaches that may help to facilitate future frailty research. In addition, several specific recommendations as to future directions were developed from suggestions put forth by participants, including recommendations on definition and phenotype development, methodological development to perform clinical studies of individual-system and multiple-system vulnerability to stressors, development of animal and cellular models, application of population-based studies to frailty research, and the development of large collaborative networks in which populations and resources can be shared. This meeting and subsequent article were not meant to be a comprehensive review of frailty research; instead, they were and are meant to provide a more-targeted research agenda-setting process.
Suppression of Soft Tissue Sarcoma Growth by a Host Defense-Like Lytic Peptide (2011)

These findings demonstrate the in vitro and in vivo oncolytic activity of [D]-K3H3L9 in athymic and syngeneic mouse models.
Urinary Tract Infection among Renal Transplant Recipients in Yemen (2015)

Urinary tract infection (UTI) is the most common complication following kidney transplantation (KT), which could result in losing the graft. This study aims to identify the prevalence of bacterial UTI among KT recipients in Yemen and to determine the predisposing factors associated with post renal transplantation UTI. A cross sectional study included of 150 patients, who underwent KT was conducted between June 2010 and January 2011. A Morning mid-stream urine specimen was collected for culture and antibiotic susceptibility test from each recipient. Bacterial UTI was found in 50 patients (33.3%). The prevalence among females 40.3% was higher than males 29%. The UTI was higher in the age group between 41-50 years with a percentage of 28% and this result was statistically significant. Predisposing factors as diabetes mellitus, vesicoureteral reflux, neurogenic bladder and polycystic kidney showed significant association. High relative risks were found for polycystic kidney = 13.5 and neurogenic bladder = 13.5. The most prevalent bacteria to cause UTI was Escherichia coli represent 44%, followed by Staphylococcus saprophyticus 34%. Amikacin was the most effective antibiotic against gram-negative isolates while Ciprofloxacin was the most effective antibiotic against Staphylococcus saprophyticus. In conclusion, there is high prevalence of bacterial UTI among KT recipients in Yemen. Diabetes mellitus, vesicoureteral reflux, neurogenic bladder, polycystic kidney and calculi were the main predisposing factors.
Electric Field Reduction in a Covered Electrode Gap due to Ionization and Charge Accumulation (2000)

The Electric Field Reduction in a Covered Electrode Gap due to Ionization and Charge Accumulation
Allelotype analysis of early colorectal cancers with lymph node metastasis (1998)

Several studies have indicated that frequent allelic losses in some specific chromosomal regions occur during colorectal cancer (CRC) progression. To clarify the correlation between such allelic losses and metastatic potential, the allelotype of lymph node-positive early CRCs, which are small but extremely malignant cancers consisting of metastatically competent cells, were investigated. Nineteen paraffin-embedded specimens of early CRC (pT1 tumors according to TNM classification) with positive lymph nodes were collected. The tumor tissues were examined for loss of heterozygosity (LOH), using microsatellite markers on chromosomes 1p34-36, 8p21-22, 14q32, 18q21 and 22q12-13. The relationship between p53 protein expression and the metastatic status was also investigated by immunohistochemical staining. A group of 20 early CRCs with negative lymph nodes having a similar distribution of macroscopic appearance were used as controls. Among the 19 node-positive tumors, LOH at 8p21-22 and 18q21 was detected in 11 cases (57.9%) and 17 cases (89.4%), respectively. Allelic losses within these 2 regions in node-positive tumors were significantly more frequent than that in node-negative ones (p < 0.01). No significant correlation was found between LOH at 1p34-36, 14q32 or 22q12-13 and lymph node metastasis. p53 protein expression was not significantly associated with lymph node metastasis. Our results suggest that putative tumor suppressor genes, which may be involved in the metastatic process of CRC, are located on chromosomes 8p21-22 and 18q21. Allelic losses in these regions are possible risk factors for lymph node metastasis of early CRC.
Effect of Infliximab on Short-Term Complications in Patients Undergoing Operation for Chronic Ulcerative Colitis (2007)

CUC patients treated with IFX before IPAA have substantially increased the odds of postoperative pouch-related and infectious complications. Additional prospective studies are required to determine if IFX alone or other factors contribute to the observed increases in infectious complications.
ChemInform Abstract: TANTALLABICYCLOALKANE COMPLEXES AND THEIR USE AS CATALYSTS FOR THE CYCLIZATION OF α,Ω‐DIENES (1981)

Abstract Die Tantalabicycloalkan‐Komplexe (III)‐(V) werden durch Umsetzung der a,w‐Diene (II) mit den Tantal‐Komplexen (I) dargestellt.
Massive release of the histamine‐degrading enzyme diamine oxidase during severe anaphylaxis in mastocytosis patients (2018)

During severe anaphylaxis in mastocytosis patients, DAO is likely released from heparin-sensitive gastrointestinal storage sites. The measured concentrations can degrade histamine, but DAO activity is compromised compared to pregnancy samples. For accurate histamine measurements during anaphylaxis, DAO inhibition is essential to inhibit further histamine degradation after blood withdrawal. Determination of DAO antigen levels might be of clinical value to improve the diagnosis of mast cell activation.
Effect of Carbonated Water on Growth Performance of Cockerels Subjected to Constant and Cyclic Heat Stress Temperatures (1985)

Three growth trials were performed to determine the effect of carbonated water on growth performance of cockerels subjected to heat stress temperatures. In Trial 1, a 2 X 2 X 2 factorial design was used to test growth performance of Columbian crossbred cockerels between 8 and 11 weeks of age. The birds were subjected to either cyclic (day-night) heat stress (H) temperature (29 to 34 C) or cyclic (day-night) moderate (M) temperature (25 to 29 C), fed either a corn soy grower (G) diet or a 20% alfalfa diet (A), and provided with tap (TW) or carbonated (CW) drinking water. In Trial 2, a 2 X 4 X 2 factorial was used to access the effect of CW on growth performance of Hubbard cockerels between 4 and 7 weeks of age. Birds were grown in the M or H cyclic thermal environments with dietary treatments consisting of A, G, A plus 1% sodium bicarbonate (AB) and G plus 1% sodium bicarbonate (GB). In Trial 3, a 2 X 2 factorial was used to test the effect of CW on growth performance of Hubbard cockerels fed the G diet and subjected to either constant heat stress (33 C) or thermoneutral (25 C) temperatures. A 24-hr photoperiod was used in each experiment. In all three trials, heat stress reduced (P less than .05) average daily gain (ADG), feed intake, and feed efficiency (G/F).(ABSTRACT TRUNCATED AT 250 WORDS)