gebhart/patrepeval huggingface dataset:
A Multi-view Approach to Preserve Privacy and Utility in Network Trace Anonymization (2021)

As network security monitoring grows more sophisticated, there is an increasing need for outsourcing such tasks to third-party analysts. However, organizations are usually reluctant to share their network traces due to privacy concerns over sensitive information, e.g., network and system configuration, which may potentially be exploited for attacks. In cases where data owners are convinced to share their network traces, the data are typically subjected to certain anonymization techniques, e.g., CryptoPAn, which replaces real IP addresses with prefix-preserving pseudonyms. However, most such techniques either are vulnerable to adversaries with prior knowledge about some network flows in the traces or require heavy data sanitization or perturbation, which may result in a significant loss of data utility. In this article, we aim to preserve both privacy and utility through shifting the trade-off from between privacy and utility to between privacy and computational cost. The key idea is for the analysts to generate and analyze multiple anonymized views of the original network traces: Those views are designed to be sufficiently indistinguishable even to adversaries armed with prior knowledge, which preserves the privacy, whereas one of the views will yield true analysis results privately retrieved by the data owner, which preserves the utility. We formally analyze the privacy of our solution and experimentally evaluate it using real network traces provided by a major ISP. The experimental results show that our approach can significantly reduce the level of information leakage (e.g., less than 1% of the information leaked by CryptoPAn) with comparable utility.
Laser-saturation spectroscopy with optical pumping (1980)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. S. Feld, M. M. Burns, T. U. Kühl, P. G. Pappas, and D. E. Murnick, "Laser-saturation spectroscopy with optical pumping," Opt. Lett. 5, 79-81 (1980) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Self-Supervised Viewpoint Learning From Image Collections (2020)

Training deep neural networks to estimate the viewpoint of objects requires large labeled training datasets. However, manually labeling viewpoints is notoriously hard, error-prone, and time-consuming. On the other hand, it is relatively easy to mine many unlabeled images of an object category from the internet, e.g., of cars or faces. We seek to answer the research question of whether such unlabeled collections of in-the-wild images can be successfully utilized to train viewpoint estimation networks for general object categories purely via self-supervision. Self-supervision here refers to the fact that the only true supervisory signal that the network has is the input image itself. We propose a novel learning framework which incorporates an analysis-by-synthesis paradigm to reconstruct images in a viewpoint aware manner with a generative network, along with symmetry and adversarial constraints to successfully supervise our viewpoint estimation network. We show that our approach performs competitively to fully-supervised approaches for several object categories like human faces, cars, buses, and trains. Our work opens up further research in self-supervised viewpoint learning and serves as a robust baseline for it. We open-source our code at https://github.com/NVlabs/SSV.
Immunogenic chemotherapy: discovery of a critical protein through proteomic analyses of tumor cells. (2007)

The aim of chemotherapy and radiotherapy is to eliminate tumor cells. While the outcomes of these cytotoxic treatments have previously been assigned to their direct effects on tumor cells, recent findings have shown that the host's immune system also contributes to the success of chemotherapeutic and radiotherapeutic regimens. The finding that some cytotoxic antitumor coumpounds such as anthracyclines were capable of triggering a potent T-cell-dependent antitumor response has prompted the search for molecular determinants responsible for the immunogenicity of anthracyclines. Proteomic analyses of anthracycline-treated tumor cells have recently revealed the critical involvement of calreticulin in mediating the immunogenicity of dying tumor cells. Here, we focused on the molecular study of immunogenic chemotherapy which led to the characterization of calreticulin as a critical protein in immunogenic cancer cell death.
Phase I Study of Subcutaneous Allergen Immunotherapy With Dermatophagoides Pteronyssinus in Patients With Allergic Rhinoconjunctivitis With or Without Asthma (2015)

Dermatophagoides pteronyssinus subcutaneous allergen immunotherapy in depot presentation exhibited good safety and tolerability. Group A seemed to show the best profile for further clinical development.
Systemic Safety of High-Dose Antibiotic-Loaded Cement Spacers after Resection of an Infected Total Knee Arthroplasty (2004)

The purpose of this study was to assess the systemic safety and potential adverse effects of using a high-dose antibiotic-impregnated cement spacer after resection arthroplasty of an infected total knee replacement. Between October 2000 and December 2002, 36 knees (34 patients) had a resection arthroplasty of an infected total knee prosthesis with placement of a high-dose antibiotic impregnated cement spacer. There were 24 men and 10 women with a mean age of 66.5 years (range, 48-84 years). All spacers placed contained an average of 3.4 batches of cement with an average total dose of 10.5 g of vancomycin (range, 3-16 g) and 12.5 g of gentamicin (range, 3.6-19.2 g). All patients were followed up post-operatively until reimplantation for evidence of renal failure. The preoperative creatinine ranged from 0.7 to 1.8 mg/dL. All patients were concomitantly treated with 6 weeks of intravenous organism-specific antibiotics. One patient with normal preoperative renal function (Cr 0.7 mg/dL) had a perioperative 1-day transient rise in serum creatinine (1.7 mg/dL) postoperatively that subsequently normalized. No patients showed any clinical evidence of acute renal insufficiency, failure, or other systemic side effects of the antibiotics. Treatment of patients with an infected total knee arthroplasty with high-dose vancomycin and gentamicin antibiotic spacers seems to be clinically safe.
Diabetes and Stem Cell Researchers Turn to the Lowly Spleen (2005)

The spleen gets no respect. Long seen as superfluous, the adult spleen of the mouse has recently been shown to hold stem cells that, in diabetic mice or genetically altered mice that lack a pancreas, effectively regenerate insulin-producing islet cells of the pancreas. Stem cells of the spleen express Hox11, a highly conserved transcription factor that plays a major role in the development of organs in vertebrate and invertebrate embryos. Hox11 and other members of the Hox family of genes may give stem cells of the spleen the capacity to mature into cell types other than islet cells, including neurons and bone cells. Multilineage splenic stem cells may trace to the embryogenesis and possible persistence into adulthood of a fetal stem cell region called the aorta-gonad-mesonephros (AGM). This Perspective calls for reappraisal of the lowly spleen for treating diabetes and other diseases of aging.
One-dimensional flat parabola antenna using synthesized EBG textures (2009)

This paper introduces a geometrically flat and electromagnetic parabolic surface and its application to an antenna is discussed. By tuning the individual cell of a mushroom-like EBG texture, an electromagnetic curved surface with a stepped reflection phase as a function of position is created. Using a parabolic phase gradient in the reflection coefficient along the face, the mushroom-like EBG structure is approximated to a concave curve inwards in the middle and concentrates a reflected wave. Furthermore, its ability to create an electromagnetic gradient surface on a geometrically flat structure allows it to replace commercial parabolic reflectors, offering low manufacturing cost, light weight, good tolerance, and so on.
Continuous Evolution Profiles for Electronic‐Tongue‐Based Analysis (2012)

Eine „elektronische Zunge“ entsteht durch Selbstorganisation auf der Oberfläche eines SPR-Imaging-Prismas (SPR=Oberflächenplasmonenresonanz) mit Kombinationen einfacher Bausteine. Der kombinatorische Array detektiert Proteine in Lösung (siehe Schema) unter Verwendung von SPR-Imaging zur Beobachtung der Wechselwirkungen. Das Signal von jedem Spot hängt von dessen Zusammensetzung und vom zugegebenen Protein ab und korreliert mit der Reaktion der Nachbar-Spots.
Toward Understanding Space-Charge Limited Current Measurements on Metal Halide Perovskites (2020)

Metal halide perovskite semiconductors have sprung to the forefront of research into optoelectronic devices and materials, largely because of their remarkable photovoltaic efficiency records above 25% in single-junction devices and 28% in tandem solar cells, achieved within a decade of research. Despite this rapid progress, ionic conduction within the semiconductor still puzzles the community and can have a significant impact on all metal halide perovskite-based optoelectronic devices because of its influence upon electronic and optoelectronic processes. This phenomenon thus also makes the interpretation of electrical characterization techniques, which probe the fundamental properties of these materials, delicate and complex. For example, space-charge limited current measurements are widely used to probe defect densities and carrier mobilities in perovskites. However, the influence of mobile ions upon these measurements is significant but has yet to be considered. Here we report the effect of mobile ions upon electronic conductivity during space-charge limited current measurements of MAPbBr3 single crystals and show that conventional interpretations deliver erroneous results. We introduce a pulsed-voltage space-charge limited current procedure to achieve reproducible current–voltage characteristics without hysteresis. From this revised pulsed current–voltage sweep, we elucidate a lower bound trap-density value of 2.8 ± 1.8 × 1012 cm–3 in MAPbBr3 single crystals. This work will lead to more accurate characterization of halide perovskite semiconductors and ultimately more effective device optimization.
Investigation of The Neural Drive During Vibration Exercise by High-density Surface-electromyography (2019)

Mechanical vibration applied directly to the muscle belly or tendon has been reported to elicit a specific reflex loop named tonic vibration reflex (TVR), which involves motor unit (MU) activation synchronized and un-synchronized within the vibration cycle. Indirect application of vibration to the muscle by vibration exercise (VE) has also been suggested to evoke TVR, as evidenced by the spectral peaks observed at the vibration frequency in the surface electromyography (sEMG). However, other studies interpreted these spectral peaks as the result of motion artifacts (MAs). The aim of the present study is, therefore, to investigate MU activation patterns during VE in order to clarify the nature of those spectral peaks. To this end, low-intensity isometric contractions were executed with and without VE, and high-density sEMG measurements were performed during the contraction tasks. MU action potential (MUAP) trains were extracted by decomposing the recorded high-density sEMG signals. The spectra of the MUAP trains were then calculated and compared between vibration and no-vibration conditions. Clear MU synchronization was observed during VE, confirming the spectral peaks at the vibration frequency to be mainly due to the reflex loop rather than MAs.
LYS12 LysM receptor decelerates Phytophthora palmivora disease progression in Lotus japonicus (2017)

Phytophthora palmivora is a devastating oomycete plant pathogen. We found that P. palmivora induces disease in Lotus japonicus and used this interaction to identify cellular and molecular events in response to this oomycete, which has a broad host range. Transcript quantification revealed that Lys12 was highly and rapidly induced during P. palmivora infection. Mutants of Lys12 displayed accelerated disease progression, earlier plant death and a lower level of defence gene expression than the wild type, while the defence program after chitin, laminarin, oligogalacturonide or flg22 treatment and the root symbioses with nitrogen-fixing rhizobia and arbuscular mycorrhiza were similar to the wild type. On the microbial side, we found that P. palmivora encodes an active chitin synthase-like protein, and mycelial growth is impaired after treatment with a chitin-synthase inhibitor. However, wheat germ agglutinin-detectable N-acetyl-glucosamine (GlcNAc) epitopes were not identified when the oomycete was grown in vitro or while infecting the roots. This indicates that conventional GlcNAc-mers are unlikely to be produced and/or accumulate in P. palmivora cell walls and that LYS12 might perceive an unknown carbohydrate. The impact of Lys12 on progression of root rot disease, together with the finding that similar genes are present in other P. palmivora hosts, suggests that LYS12 might mediate a common early response to this pathogen.
Partially Shared Deep Neural Network for Sound Source Identification (2016)

This paper addresses Deep Neural Network (DNN) for Sound Source Identification (SSI) of acoustic signals recorded with a microphone array embedded in an Unmanned Aerial Vehicle (UAV), aiming at people’s voice detection quickly and widely in a disastrous situation. It is well known that training a SSI-DNN needs huge dataset to improve its performance, but building such a dataset is not often realistic owing to the cost of annotation done by human. Therefore, we propose Partially Shared Deep Neural Network (PS-DNN) training using noise-suppressed acoustic signals, which can be obtained in automatic process, in addition to label data annotated by human. This results in more accurate SSI in the situation of lack of dataset for training.
Flexible two-phase thermosyphon for power electronic cooling (2011)

A two phase thermosyphon system for power electronic cooling is presented. The designed evaporator can house multiple power electronics modules, it collects the generated vapor to a common flexible tube that drives the vapor to a plate heat exchanger condenser. The system was tested and simulated for a total power loss of 12.5 kW. The condenser was installed at a distance of 3 m from the evaporator enabling flexibility from a customer side concerning location and distance where the heat is finally dumped to ambient. The evaporator is a novel design and it consists of a bottom liquid collector (i.e. it is a pool of liquid constantly feeding the evaporator channels) and a two-phase mixture collector at the top evaporator that collects the discharged two-phase flow and separates the liquid part from the vapor allowing the vapor to travel without liquid to the condenser. The system works with gravity driven circulation. Thermal performances of the system are presented and compared to the simulation results of a dedicated two-phase code developed by ABB. The total power dissipation investigated ranges between 5 and 12.5 kW. This is attained by three power modules Econopack Plus from Infineon. The condensation is provided by means of a water cooled plate heat exchanger. Results will be presented for a cooling water temperature of 38 and 50°C. The working fluid was refrigerant R245fa.
Multiscale computational understanding and growth of 2D materials: a review (2020)

Abstract The successful discovery and isolation of graphene in 2004, and the subsequent synthesis of layered semiconductors and heterostructures beyond graphene have led to the exploding field of two-dimensional (2D) materials that explore their growth, new atomic-scale physics, and potential device applications. This review aims to provide an overview of theoretical, computational, and machine learning methods and tools at multiple length and time scales, and discuss how they can be utilized to assist/guide the design and synthesis of 2D materials beyond graphene. We focus on three methods at different length and time scales as follows: (i) nanoscale atomistic simulations including density functional theory (DFT) calculations and molecular dynamics simulations employing empirical and reactive interatomic potentials; (ii) mesoscale methods such as phase-field method; and (iii) macroscale continuum approaches by coupling thermal and chemical transport equations. We discuss how machine learning can be combined with computation and experiments to understand the correlations between structures and properties of 2D materials, and to guide the discovery of new 2D materials. We will also provide an outlook for the applications of computational approaches to 2D materials synthesis and growth in general.
Regulation of Phospholipase C-β3 Activity by Na+/H+ Exchanger Regulatory Factor 2 (2000)

Among the phospholipase C that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate, four mammalian phospholipase C-beta (PLC-beta) isotypes (isotypes 1-4) are activated through G protein-coupled receptors (GPCRs). Although the regulation of the PLC-betas by GPCRs and heterotrimeric G proteins has been extensively studied, little is known about the molecular determinants that regulate their activity. The PLC-beta isozymes carry a putative PSD-95/Dlg/ZO-1 (PDZ) binding motif (X(S/T)X(V/L)COOH) at their carboxyl terminus, which is implicated in specific interactions with anchor proteins. Using the yeast two-hybrid system, we identified Na(+)/H(+) exchanger regulatory factor 2 (NHERF2) as a protein that interacted with a C-terminal heptapeptide of PLC-beta3. Immunoprecipitation studies revealed that NHERF2 interacts specifically with PLC-beta3, but not with other PLC-beta isotypes. Furthermore, PLC-beta3 interacted with NHERF2 rather than with other PDZ-containing proteins. This interaction required the COOH-terminal NTQL sequence of PLC-beta3 and the second PDZ domain of NHERF2. Interestingly, NHERF2 potentiated the PLC-beta activation by carbachol in COS7 and HeLa cells, while mutant NHERF2, lacking the second PDZ domain, had no such effect. Taken together, the data suggest that NHERF2 may act as a modulator underlying the process of PLC-beta3-mediated signaling.
Analytic Behavior and Trust Building in Visual Analytics (2016)

Visual Analytics (VA) is a collaborative process between human and computer, where analysts are performing numerous interactions and reasoning activities. This paper presents our current progress in developing a note taking environment (NTE) that can be plugged to any VA system. The NTE supports the analysis process on the one hand, and captures user interactions on the other hand. Our aim is to integrate human lower- (exploration) with higher- (verification) level analytic processes and to investigate those together related to further human factors, such as trust building. We conducted a user study to collect and investigate analytic provenance data. Our early results reveal that analysis strategies and trust building are very individual. However, we were able to identify significant correlations between trust levels and interactions of particular participants.
Cleavage of Disulfide Bonds in Mouse Spermatogenic Cell-Specific Type 1 Hexokinase Isozyme Is Associated with Increased Hexokinase Activity and Initiation of Sperm Motility1 (2020)

During epididymal transit, sperm acquire the ability to initiate rapid forward progressive motility on release into the female reproductive tract or physiological media. Glycolysis is the primary source of the ATP necessary for this motility in the mouse, and several novel glycolytic enzymes have been identified that are localized to the principal piece region of the flagellum. One of these is the spermatogenic cell-specific type 1 hexokinase isozyme (HK1S), the only member of the hexokinase enzyme family detected in sperm. Hexokinase activity was found to be lower in immotile sperm immediately after removal from the cauda epididymis (quiescent) than in sperm incubated in physiological medium for 5 min and showing rapid forward progressive motility (activated). However, incubating sperm in medium containing diamide, an inhibitor of disulfide bond reduction, resulted in lower motility and HK activity than in controls. HK1S was present in dimer and monomer forms in extracts of quiescent sperm but mainly as a monomer in motile sperm. A dimer-size band detected in quiescent sperm with phosphotyrosine antibody was not detected in activated sperm, and the monomer-size band was enhanced. In addition, the general protein oxido-reductase thioredoxin-1 was able to catalyze the in vitro conversion of HK1S dimers to the monomeric form. These results strongly suggest that cleavage of disulfide bonds in HK1S dimers contributes to the increases in HK activity and motility that occur when mouse sperm become activated.
Phase transition to the conducting state in a system of charge-transfer excitons at a donor-acceptor interface (1999)

We discuss the phase transition to the conducting state in a system of 2D charge-transfer excitons (CTEs) at a donor-acceptor interface. The phase transition arises due to strong dipole-dipole repulsion between CTEs which stimulates the population of free carriers in higher energy states even at low temperature. We use the computer simulations with the random distribution of excitons, with finite lifetime explicitly taken into account. The critical concentration of CTEs and their energy distribution are calculated. We also discuss the possibility of observing the predicted phenomena.
Supplementary Figure 1 from miR-212 Increases Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Sensitivity in Non–Small Cell Lung Cancer by Targeting the Antiapoptotic Protein PED (2023)

Supplementary Figure 1 from miR-212 Increases Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Sensitivity in Non–Small Cell Lung Cancer by Targeting the Antiapoptotic Protein PED
n→π* Interactions in Helices (2013)

We extend to you a warm and sunny Aloha in celebration of the 23 rd American Peptide Symposium and the 6 th International Symposium. The meeting theme, Peptides Across the Pacific, embraced the spirit of the scientific and social program. Peptides Across the Pacific encompassed the important role that peptide science currently plays in so many disciplines and explored the potential impact peptides can make in scientific fields that have yet to realize the utility of these wonderful molecules.