gebhart/patrepeval huggingface dataset:
Emicizumab‐mediated haemostatic function in patients with haemophilia A is down‐regulated by activated protein C through inactivation of activated factor V (2018)

Activated protein C (APC) inactivates activated factor V (FVa) and moderates FVIIIa by restricting FV cofactor function. Emicizumab is a humanized anti-FIXa/FX bispecific monoclonal antibody that mimicks FVIIIa cofactor function. In recent clinical trials in haemophilia A patients, once-weekly subcutaneous administration of emicizumab was remarkably effective in preventing bleeding events, but the mechanisms controlling the regulation of emicizumab-mediated haemostasis remain to be explored. We investigated the role of APC-mediated reactions in these circumstances. APC dose-dependently depressed thrombin generation (TG) initiated by emicizumab in FVIII-deficient plasmas, and in normal plasmas preincubated with an anti-FVIII antibody (FVIII-depleted). FVIIIa-independent FXa generation with emicizumab was not affected by the presence of APC, protein S and FV. The results suggested that APC-induced down-regulation of emicizumab-dependent TG was accomplished by direct inactivation of FVa. The addition of APC to emicizumab mixed with FVIII-depleted FV-deficient plasma in the presence of various concentrations of exogenous FV demonstrated similar attenuation of TG, irrespective of specific FV concentrations. Emicizumab-related TG in FVIII-depleted FV<sub>Leiden</sub> plasma was decreased by APC more than that observed with native FV<sub>Leiden</sub> plasma. The findings indicated that emicizumab-driven haemostasis was down regulated by APC-mediated FVa inactivation in plasma from haemophilia A patients without or with FV defects.
Susceptibility of Mycobacterium bovis BCG Vaccine Strains to Antituberculous Antibiotics (2008)

Mycobacterium bovis BCG is one of the most commonly administered vaccines. Complications, including disseminated BCG disease, are rare but increasingly reported in immunodeficient children. There is growing recognition of the importance of differences between BCG vaccine strains. We determined the susceptibilities of five genetically distinct BCG vaccine strains to 12 antituberculous drugs.
Evaluation of penetration of cosmetic liquids using terahertz time of flight method (2018)

The terahertz time-of-flight method was applied to evaluate the the penetration speed and the depth of the skin lotion into the skin. The result suggests that the terahertz time-of-flight method is one of useful option in this field.
Contributing Factors of Anxiety and Depressive Symptoms in a Group of Cancer Outpatients Undergoing Chemotherapy (2008)

No abstract available.
Multi-Constellation DGNSS - A Time to Revise Definitions (2020)

A paper describes a novel approach to computing DGNSS solution when multi-GNSS measurement observables are available. The approach is applicable to situations when not all the GNSS observables are accompanied with DGNSS corrections. A commonly used “classical” recommendation for such cases is to discard observables which do not have corrections. However, in challenging conditions like urban canyon this recommendation might lead to a case, when such “correct” DGNSS solution might be of poorer quality than the stand-alone one. This is especially true for SBAS, as all operating systems broadcast GPS-only corrections, while user receiver might be capable of tracking signals of GLONASS, Beidou, GALILEO, NavIC in addition to GPS. The suggested in the paper approach is based on rather straightforward methodology, according to which all observables are divided by groups, depending on GNSS type and correction data availability. In the process of computing the position several new unknowns are introduced - one for every group, to estimate clock offsets associated with every group. This approach is implemented in the newest firmware of Topcon receiver boards, which is going to be released soon. The paper provides positioning algorithm's description and results, demonstrating benefits of the suggested approach over the “classical” one. In addition, a paper touches a problem of necessity to revise a definition of “DGNSS mode”, as today there is no term for designating a solution, computed with a mixture of corrected and uncorrected observables.
Prediction of Deformation Behavior of Steel Sheets Based on Crystallographic Texture (1990)

Stress-strain curves under various multiaxial stress states and yield loci of steel sheets were calculated using measured texture data and a crystallographical theory. A textured polycrystalline sheet is simplified to be an aggregate of many single crystals with various orientations. A Crystallite Orientation Distribution Function (CODF) which was calculated from measured texture data was used as a volume fraction of a certain oriented crystal. Considering restricted glide on slip systems as a deformation mode of a single crystal, a strain tensor in each crystal subjected to various multiaxial stress states was calculated. In order to calculate a strain tensor for a textured polycrystalline sheet, the calculated strain for each single crystal was weighted by the CODF and averaged over all orientations. The calculated results are compared with experimental ones for two low carbon steel sheets. The behavior of strain-hardening and a planar anisotropy of the calculated stress-strain relation are in good agreement with the experiment. The calculated yield locus can also represent a general shape of the measured one.
Multilevel Coding for the Broadcast Channel: Optimality &amp; Near-Optimal Constructions (2016)

The capacity of the AWGN broadcast is achieved by superposition coding, but superposition of individual coded modulations does not in general obey a predefined constellation. We propose a coded modulation broadcast with strict channel input modulation constraint via multilevel coding (MLC). For a degraded broadcast channel, conditions of optimality of the multilevel decomposition of a superposition code are derived. Furthermore, a constructive scheme is proposed that simplifies the superposition multilevel code and facilitates the design process, by reducing the inter-dependencies between the levels of the two component codes, and yet achieves rates very close to the constellation constrained capacity. Simulation results on several modulations verify the operation of the proposed coding scheme at or near the constellation constrained capacity.
A Knowledge Driven Policy Framework for Internet of Things (2017)

With the proliferation of technology, connected and interconnected devices (henceforth referred to as IoT) are fast becoming a viable option to automate the day-to-day interactions of users with their environment—be it manufacturing or home-care automation. However, with the explosion of IoT deployments we have observed in recent years, manually governing the interactions between humans-to-devices—and especially devices-to- devices—is an impractical task, if not an impossible task. This is because devices have their own obligations and prohibitions in context, and humans are not equip to maintain a bird’s-eye-view of the interaction space. Motivated by this observation, in this paper, we propose an end-to-end framework that (a) automatically dis- covers devices, and their associated services and capabilities w.r.t. an ontology; (b) supports representation of high-level—and expressive—user policies to govern the devices and services in the environment; (c) pro- vides efficient procedures to refine and reason about policies to automate the management of interactions; and (d) delegates similar capable devices to fulfill the interactions, when conflicts occur. We then present our initial work in instrumenting the framework and discuss its details.
Chromaffin cell survival from both young and old donors is enhanced by co-grafts of polymer-encapsulated human NGF-secreting cells (1996)

Following polymer-encapsulation, human nerve growth factor-secreting baby hamster kidney fibroblasts (BHK-hNGF) were implanted into the striatum of hemiparkinsonian rats together with unencapsulated adrenal medullary chromaffin cells from either young (2 weeks) or old (12 months) donor rats. Animals receiving both BHK-hNGF cells and chromaffin cells exhibited significant decreases (39-56%) in apomorphine-induced rotational behaviour which was equivalent regardless of the age of the donor tissue. Histological analysis revealed that while survival of chromaffin cells without hNGF support was poor, co-grafts of adrenal medulla and BHK/hNGF cells increased chromaffin cell survival by 20 times. Again, this effect was independent of the age of the donor tissue. Retrieved capsules contained numerous viable encapsulated BHK-hNGF cells which continued to release hNGF. These results further indicate the potential use of intrastriatal implantation of encapsulated hNGF-secreting cells for augmenting the survival of co-grafted chromaffin cells as well as promoting the functional recovery of hemiparkinsonian rats.
Automatic pre-processing after image robustness analysis (2005)

The characteristic response curve of an imaging system is measured, to determine the system linearity. Images to be watermarked are analyzed to check if at least a prescribed target minimum of pixels is in the linear section of the imaging system response. When this criterion is met, the image data is left unchanged. However when it is not met, a tone correction is calculated and applied to the image. The automatic preprocessing of problem images increases their robustness and reduces the variance in robustness of a set of watermarked images.
Effects of indol-3-carbinol(I3C) on tight junction activity in prostate cancer cells- LNCAP, PC3 and DU145. (2006)

Fifth AACR International Conference on Frontiers in Cancer Prevention Research, Nov 12-15, 2006

B115 

To determine whether I3C inhibits the cell motility, progression and metastasis of prostate cancer cells, this experiment was performed. Indole-3-carbinol (I3C) is a compound found in cruciferous vegetables such as cabbage, cauliflower, broccoli and Brussels sprouts. Our results indicate that I3C inhibit cell growth of LNCAP, PC3 cells in a dose(50uM, 100uM) and time(24, 48 and 72 hrs) dependent manner. Using the wound healing experiment and cell invasion study, I3C inhibits the cell motility of the prostate adenocarcinoma cell line, DU145. The TER values was increased in DU145 cells grown in transwells treated with I3C. Claudin-3 and claudin-4 have been shown to be overexpressed in prostate cancer cells and in particular, in metastatic prostate cancer cells. But I3C occurs concurrently with a significant decrease in the levels of the proteins, claudin-3 and claudin-4 in prostate cancer cells but those of PC3 were not significantly different. This result suggests that I3C may be expected to inhibit cancer progression and metastasis by restoring tight junction and their composite protein in prostate cancer.
Post-Silicon Validation of the IBM POWER8 Processor (2014)

The post-silicon validation phase in a processor's design life cycle is geared towards finding all remaining bugs in the system. It is, in fact, our last opportunity to find functional and electrical bugs in the design before shipping it to customers.
ShadowGuides (2009)

We present ShadowGuides, a system for in-situ learning of multi-touch and whole-hand gestures on interactive surfaces. ShadowGuides provides on-demand assistance to the user by combining visualizations of the user's current hand posture as interpreted by the system (feedback) and available postures and completion paths necessary to finish the gesture (feedforward). Our experiment compared participants learning gestures with ShadowGuides to those learning with video-based instruction. We found that participants learning with ShadowGuides remembered more gestures and expressed significantly higher preference for the help system.
THE INFLUENCE OF ELECTROLYTIC MASS TRANSFER ON THE PERFORMANCE OF PHOTOELECTROCHEMICAL CELLS (1987)

Abstract A one-dimensional mathematical model of a photoelectrochemical cell is developed which accounts explicitly for the transport, generation, and recombination of electrons and holes in the semiconductor, the coupling among interfacial reactions, and transport of electrolytic species by diffusion, migration, and convection. This model is used to show the degree of coupling expected between processes taking place in the semiconductor and in the electrolyte. The influence of electrolytic mass-transfer was evaluated for an n-type GaAs semiconductor in contact with a 0.80 M K2Se2, 0.10 M K2Se2, 1.0 M KOH electrolyte. Calculated current-potential curves were shown to be relatively unaffected by limitations to electrolytic mass transfer, even at large fractions of the limiting current. The magnitude of charge held within the electrolytic double layer and the space-charge region of the semi-conductor is relatively invariant for currents significantly below the limiting current, but increases as the mass-transfer-limited current is approached. The hole concentration at the semiconductor-electrolyte interface increases as kinetic and mass-transfer limitations to interfacial reactions are approached. The implications of these results for the stability of photoelectrochemical cells and for the application of photoelectrochemical techniques to semiconductor processing are discussed.
SMART: Simultaneous Multi-Agent Recurrent Trajectory Prediction (2020)

We propose advances that address two key challenges in future trajectory prediction: (i) multimodality in both training data and predictions and (ii) constant time inference regardless of number of agents. Existing trajectory predictions are fundamentally limited by lack of diversity in training data, which is difficult to acquire with sufficient coverage of possible modes. Our first contribution is an automatic method to simulate diverse trajectories in the top-view. It uses pre-existing datasets and maps as initialization, mines existing trajectories to represent realistic driving behaviors and uses a multi-agent vehicle dynamics simulator to generate diverse new trajectories that cover various modes and are consistent with scene layout constraints. Our second contribution is a novel method that generates diverse predictions while accounting for scene semantics and multi-agent interactions, with constant-time inference independent of the number of agents. We propose a convLSTM with novel state pooling operations and losses to predict scene-consistent states of multiple agents in a single forward pass, along with a CVAE for diversity. We validate our proposed multi-agent trajectory prediction approach by training and testing on the proposed simulated dataset and existing real datasets of traffic scenes. In both cases, our approach outperforms SOTA methods by a large margin, highlighting the benefits of both our diverse dataset simulation and constant-time diverse trajectory prediction methods.
Combined Anteversion Technique for Total Hip Arthroplasty (2008)

Level II, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.
Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: Molecular basis of isozyme‐drug discrimination (1998)

Carbonic anhydrase IV (CAIV) is a membrane-associated enzyme anchored to plasma membrane surfaces by a phosphatidylinositol glycan linkage. We have determined the 2.8-angstroms resolution crystal structure of a truncated, soluble form of recombinant murine CAIV. We have also determined the structure of its complex with a drug used for glaucoma therapy, the sulfonamide inhibitor brinzolamide (Azopt). The overall structure of murine CAIV is generally similar to that of human CAIV; however, some local structural differences are found in the active site resulting from amino acid sequence differences in the "130's segment" and the residue-63 loop (these may affect the nearby catalytic proton shuttle, His-64). Similar to human CAIV, the C-terminus of murine CAIV is surrounded by a substantial electropositive surface potential that may stabilize the interaction with the phospholipid membrane. Binding interactions observed for brinzolamide rationalize the generally weaker affinity of inhibitors used in glaucoma therapy toward CAIV compared with CAII.
Podoscyphic Acid, A New Inhibitor Of Avian Myeloblastosis Virus And Moloney Murine Leukemia Virus Reverse Transcriptase From A Podoscypha Species [1] (1991)

A novel enzyme inhibitor of RNA-directed DNA-polymerases of avian myeloblastosis and murine leukemia virus was isolated from fermentations of an tasmanian Podoscypha species. Its structure was elucidated by spectroscopic methods and oxidative degradation as (E)-4,5-dioxo-2-hexadecenoic acid (1). The enzyme inhibitor, which was named podoscyphic acid, did not inhibit DNA and RNA synthesis in permeabilized L 1210 cells nor did it affect RNA synthesis in isolated nuclei of L 1210 cells. 1 inhibits protein synthesis in whole L 1210 cells and rabbit reticulocyte lysate and shows very weak antimicrobial and cytotoxic properties. The testing of ethyl (E)-4,5-dioxo-2-hexadecenoate (2) and (E)-4-oxo-2-tetradecenoic acid (11) revealed the importance of the free gamma-oxoacrylic acid unit for the biological activities of 1.
Energy Harvesting Electronics for Vibratory Devices in Self-Powered Sensors (2011)

Recent advances in energy harvesting have been intensified due to urgent needs of portable, wireless electronics with extensive life span. The idea of energy harvesting is applicable to sensors that are placed and operated on some entities for a long time, or embedded into structures or human bodies, in which it is troublesome or detrimental to replace the sensor module batteries. Such sensors are commonly called “self-powered sensors.” The energy harvester devices are capable of capturing environmental energy and supplanting the battery in a standalone module, or working along with the battery to extend substantially its life. Vibration is considered one of the most high power and efficient among other ambient energy sources, such as solar energy and temperature difference. Piezoelectric and electromagnetic devices are mostly used to convert vibration to ac electric power. For vibratory harvesting, a delicately designed power conditioning circuit is required to store as much as possible of the device-output power into a battery. The design for this power conditioning needs to be consistent with the electric characteristics of the device and battery to achieve maximum power transfer and efficiency. This study offers an overview on various power conditioning electronic circuits designed for vibratory harvester devices and their applications to self-powered sensors. Comparative comments are provided in terms of circuit topology differences, conversion efficiencies and applicability to a sensor module.
High peak power operation of a 100μm-core Yb-doped rod-type photonic crystal fiber amplifier (2010)

We report on the performance of an Yb-doped, 100&mu;m-core, rod-type photonic crystal fiber (PCF) used as the power amplifier in an actively controlled master-oscillator/power-amplifier optical (MOPA) source. Such PCF is the largestcore fiber to date to exhibit concurrent single-mode beam quality and robust linear polarization in its output. From this MOPA, we obtained peak power in excess of 1.35MW with excellent spectral brightness.
Radio Interface Protocols (2007)

This chapter contains sections titled: Introduction Protocol Architecture The Medium Access Control Protocol The Radio Link Control Protocol The Packet Data Convergence Protocol The Broadcast/Multicast Control Protocol Multimedia Broadcast Multicast Service The Radio Resource Control Protocol Early UE Handling Principles Improvements for Call Setup Time Reduction References
Pathological Concordance and Surgical Outcomes of Sporadic Synchronous Unilateral Multifocal Renal Masses Treated with Partial Nephrectomy (2012)

In what is to our knowledge the largest published report of unilateral synchronous multifocal renal masses we document low pathological concordance rates. As such, percutaneous biopsy of a single renal mass in these patients may not help inform treatment decisions. Nephron sparing surgery may be performed with acceptable oncological and functional results in patients with unilateral synchronous multifocal renal masses.
Identification of Conjugate Adducts Formed in the Reactions of Malonaldehyde-Acetaldehyde and Malonaldehyde-Formaldehyde with Cytidine (2002)

Malonaldehyde was reacted with cytidine in buffered aqueous solutions in the presence of acetaldehyde or formaldehyde. The reaction mixtures were analyzed by HPLC, and the products were isolated by preparative C18 chromatography and structurally characterized by UV absorbance, fluorescence emission, (1)H and (13)C NMR spectroscopy, and mass spectrometry. The major adducts formed in the reaction of malonaldehyde and acetaldehyde were identified as 7-(beta-D-ribofuranosyl)-4-methyl-6-oxo-6,7-dihydro-4H-pyrimido[1,6-a]pyrimidine-3-carbaldehyde (M(1)AA-Cyd) and 1-(beta-D-ribofuranosyl)-4-(3,5-diformyl-4-methyl-1,4-dihydro-1-pyridyl)pyrimidine (M(2)AA-Cyd). In the reaction of malonaldehyde and formaldehyde, the major product was identified as 7-(beta-D-ribofuranosyl)-6-oxo-6,7-dihydro-4H-pyrimido[1,6-a]pyrimidine-3-carbaldehyde (M(1)FA-Cyd). The highest yields of M(1)AA-Cyd and M(2)AA-Cyd, 3.2 and 0.5 mol %, respectively, were obtained in the reaction performed at pH 4.6 and 37 degrees C for 8 days, while M(1)FA-Cyd was produced at a yield of 0.3 mol % after 3 days of reaction at pH 4.0 and 37 degrees C. The products consist of units derived from malonaldehyde and acetaldehyde (M(1)AA-Cyd and M(2)AA-Cyd) or from malonaldehyde and formaldehyde (M(1)FA-Cyd), and are thus further examples of nucleoside modifications containing structural elements derived from aldehyde condensation reactions. Trace amounts of the adducts may be formed at physiological conditions and may be involved in the mutagenicity of the studied aldehydes.
Knowledge Graph Constraints for Multi-label Graph Classification (2016)

Graph classification methods have gained increasing attention in different domains, such as classifying functions of molecules or detection of bugs in software programs. Similarly, predicting events in manufacturing operations data can be compactly modeled as graph classification problem. Feature representations of graphs are usually found by mining discriminative sub-graph patterns that are non-uniformly distributed across class labels. However, as these feature selection approaches are computationally expensive for multiple labels, prior knowledge about label correlations should be exploited as much as possible. In this work, we introduce a new approach for mining discriminative sub-graph patterns with constraints that are extracted from links between labels in knowledge graphs which indicate label correlations. The incorporation of these constraints allows to prune the search space and ensures extraction of consistent patterns. Therefore, constraint checking remains efficient and more robust classification results can be obtained. We evaluate our approach on both, one public and one custom simulated data set. Evaluation confirms that incorporation of constraints still results in efficient pattern mining and can increase performance of state-of-the-art approaches.
Bayesian Single Channel Speech Enhancement Exploiting Sparseness In The Ica Domain (2004)

Publication in the conference proceedings of EUSIPCO, Viena, Austria, 2004