gebhart/patrepeval huggingface dataset:
Molecular events underlying interleukin‐6 independence in a subclone of the CMA‐03 multiple myeloma cell line (2013)

We explored the molecular mechanisms involved in the establishement of CMA-03/06, an IL-6-independent variant of the multiple myeloma cell line CMA-03 previously generated in our Institution. CMA-03/06 cells grow in the absence of IL-6 with a doubling time comparable with that of CMA-03 cells; neither the addition of IL6 (IL-6) to the culture medium nor co-culture with multipotent mesenchymal stromal cells increases the proliferation rate, although they maintain the responsiveness to IL-6 stimulation as demonstrated by STAT1, STAT3, and STAT5 induction. IL-6 independence of CMA-03/06 cells is not apparently due to the development of an autocrine IL-6 loop, nor to the observed moderate constitutive activation of STAT5 and STAT3, since STAT3 silencing does not affect cell viability or proliferation. When compared to the parental cell line, CMA-03/06 cells showed an activated pattern of the NF-κB pathway. This finding is supported by gene expression profiling (GEP) analysis identifying an appreciable fraction of modulated genes (28/308) in the CMA-03/06 subclone reported to be involved in this pathway. Furthermore, although more resistant to apoptotic stimuli compared to the parental cell line, CMA-03/06 cells display a higher sensibility to NF-κB inhibition induced by bortezomib. Finally, GEP analysis suggests an involvement of a number of cytokines, which might contribute to IL-6 independence of CMA-03/06 by stimulating growth and antiapoptotic processes. In conclusion, the parental cell-line CMA-03 and its variant CMA-03/06 represent a suitable model to further investigate molecular mechanisms involved in the IL-6-independent growth of myeloma cells.
Agglomeration and dissociation of vacancies in electroless deposited Cu films studied by monoenergetic positron beams (2012)

Positron annihilation is used to probe vacancy-type defects in electroless deposited (ELD) Cu films on Ta/TaN/SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /Si. Doppler broadening spectra of the annihilation radiation and lifetime spectra of positrons are measured for ELD-Cu fabricated with different residual impurity concentrations using a novel electrolyte. For as-deposited films, the major species of vacancy-type defects are identified as vacancy complexes (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> -V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> ) and larger vacancy clusters (~V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10</sub> ). After annealing around 200°C, they diffuse toward the surface and aggregate. The same trend is observed for sulfur, suggesting the formation of complexes between sulfur and vacancies. Although the defects near the surface anneal out above 300°C, the defect concentration near the Cu/barrier-metal interface is high even after annealing above 600°C, suggesting an accumulation of vacancy-impurity complexes. The observed defect reactions are attributed to the suppression of the vacancy diffusion to sinks by the formation of impurity-vacancy complexes. Through careful control of the concentration of residual impurities and their species, these electroless Cu films have a high potential to suppress the formation of voids/hillocks caused by defect migration.
MORPHOLOGICAL STUDY OF THE SPINAL MOTONEURONS CONTROLLING THE URETHRAL SPHINCTER OF FEMALE RATS: ROLE OF ANDROGENS IN A MENOPAUSAL MODEL (2005)

The modifications of androgen receptor expression and somal morphological appearance in the pudendal motoneurons controlling the external urethral sphincter of ovariectomized female rats suggests that testosterone probably influences neurotransmission and coordination of urinary continence at the spinal level.
Performance Study of W-CDMA Adaptive Array Antennas (2006)

The effect of the antenna geometry and the adaptive algorithm on the performance of a W-CDMA adaptive array antenna for mobile terminals is investigated experimentally. A W-CDMA receiving system for a 4-element array antenna is developed. The adaptive algorithm and the array antenna configuration are changed according to the requirement of the investigation. The performance of the system including synthesized pattern, adaptive weight and bit-error-rate (BER) characteristics are measured for the performance analysis. Results show that signal-to-interference ratio (SIR) can be greatly improved by 6 to 10 dB compared with the single antenna when BER is equal to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> . BER of the single monopole with a reflector is lower than that of the single monopole because the monopole with reflector has a higher gain in the direction of the desired wave. However, the SIR improvement of the monopole array is larger than that of the monopole array with a reflector because the array element gain of the monopole to the direction of the interference is larger. It seems that array elements which have homogeneous radiation pattern and high radiation efficiency are suitable to the adaptive array antennas
Subband Method for Multichannel Least Squares Equalization of Room Transfer Functions (2007)

Equalization of room transfer functions (RTFs) is important in many speech and audio processing applications. It is a challenging problem because RTFs are several thousand taps long and non-minimum phase and in practice only approximate measurements of the RTFs are available. In this paper, we present a subband multichannel least squares method for equalization of RTFs which is computationally efficient and less sensitive to inaccuracies in the measured RTFs compared to its fullband counterpart. Experimental results using simulated impulse responses demonstrate the performance of the algorithm.
Ion mobility spectrometry–mass spectrometry (IMS–MS) for on- and offlineanalysis of atmospheric gas and aerosol species (2016)

Abstract. Measurement techniques that provide molecular-level information are needed to elucidate the multiphase processes that produce secondary organic aerosol (SOA) species in the atmosphere. Here we demonstrate the application of ion mobility spectrometry-mass spectrometry (IMS–MS) to the simultaneous characterization of the elemental composition and molecular structures of organic species in the gas and particulate phases. Molecular ions of gas-phase organic species are measured online with IMS–MS after ionization with a custom-built nitrate chemical ionization (CI) source. This CI–IMS–MS technique is used to obtain time-resolved measurements (5 min) of highly oxidized organic molecules during the 2013 Southern Oxidant and Aerosol Study (SOAS) ambient field campaign in the forested SE US. The ambient IMS–MS signals are consistent with laboratory IMS–MS spectra obtained from single-component carboxylic acids and multicomponent mixtures of isoprene and monoterpene oxidation products. Mass-mobility correlations in the 2-D IMS–MS space provide a means of identifying ions with similar molecular structures within complex mass spectra and are used to separate and identify monoterpene oxidation products in the ambient data that are produced from different chemical pathways. Water-soluble organic carbon (WSOC) constituents of fine aerosol particles that are not resolvable with standard analytical separation methods, such as liquid chromatography (LC), are shown to be separable with IMS–MS coupled to an electrospray ionization (ESI) source. The capability to use ion mobility to differentiate between isomers is demonstrated for organosulfates derived from the reactive uptake of isomers of isoprene epoxydiols (IEPOX) onto wet acidic sulfate aerosol. Controlled fragmentation of precursor ions by collisionally induced dissociation (CID) in the transfer region between the IMS and the MS is used to validate MS peak assignments, elucidate structures of oligomers, and confirm the presence of the organosulfate functional group.
Transient thermoreflectance of thin metal films in the picosecond regime (1988)

The distributed nature of the reflection process is considered for pump-and-probe-type picosecond transient thermoreflectance (PTTR) measurements. A first-order approximation is given for the temporal dependence of the reflectivity for temperature distributions created by picosecond laser pulses. It was found that PTTR flashes back the temperature profile created by the pump pulse. The problem of determining the thermal transport properties from PTTR measurements is discussed.
Metamaterial-enabled Reflectarray Antennas for High-power Microwave Applications (2020)

Metamaterial reflectarray antennas are attractive options for reducing system SWaP (size, weight, and power) compared to conventional reflector antennas. However, it has been a long-held belief that metamaterials are unsuitable for high-power microwave applications due to their strong field enhancement behaviors. Here we demonstrate that, fortunately, this challenge can be overcome by judiciously combining state-of-the-art optimization with intelligent material selection and metamaterial geometry.
Oleanolic Acid Acetate Inhibits Mast Cell Activation in Ovalbumin-Induced Allergic Airway Inflammation (2023)

Our study showed that OAA can inhibit mast cell-mediated allergic reaction. Consequently, the application of OAA to mast cells for the allergic airway inflammation facilitate a new direction of treating allergic asthma.
Curli Production and Genetic Relationships Among Escherichia coli from Cases of Bovine Mastitis (2007)

Curli are adhesive surface structures produced by some Escherichia coli and Salmonella strains that bind host proteins and activate inflammatory mediators. In this study, 61 E. coli isolates from 36 clinical cases of bovine mastitis were characterized using enterobacterial repetitive intergenic consensus-PCR and screened for their ability to produce curli. Effect of curli production on case recovery, based on a return to precase milk yield, was investigated for a subset of 43 isolates from 20 quarters of 19 cows. Thirty-five (57%) of 61 isolates were curli positive. Fifty-eight of the 61 isolates clustered into 2 clonal groups at 52% genetic similarity. Genetically diverse E. coli isolates were simultaneously cultured from individual cases. Twenty-three isolates from 13 cows were clustered in clonal group I, of which 5 cases (38%) were curli positive; 35 isolates from 22 cows were clustered in clonal group II, of which 15 cases (68%) were curli positive. No association was found between genetic similarity and phenotypic curli expression of isolates from cows with clinical E. coli mastitis cases. Phenotypic curli expression in isolates did not affect recovery of cows' milk yield to premastitis production levels.
Design rules for field plate edge termination in SiC Schottky diodes (2001)

Practical design of silicon carbide (SiC) Schottky diodes incorporating a field plate necessitates an understanding of how the addition of the field plate affects the performance parameters and the relationship between the diode structure and diode performance. In this paper, design rules are presented for SiC Schottky diodes that incorporate field plate edge termination. The use of an appropriate field plate edge termination can improve the reverse breakdown voltage of a SiC Schottky diode by a factor of two. Reverse breakdown voltage values can be obtained that are up to 88% of the theoretical maximums.
Nanoscale Interface Modification of LiCoO2by Al2O3Atomic Layer Deposition for Solid-State Li Batteries (2012)

Cycle stability of solid-state lithium batteries (SSLBs) using a LiCoO2 cathode is improved by atomic layer deposition (ALD) on active material powder with Al2O3. SSLBs with LiCoO2/Li3.15Ge0.15P0.85S4/77.5Li2S-22.5P2S5/Li structure were constructed and tested by charge-discharge cycling at a current density of 45 μA cm−2 with a voltage window of 3.3 ∼ 4.3 V (vs. Li/Li+). Capacity degradation during cycling is suppressed dramatically by employing Al2O3 ALD-coated LiCoO2 in the composite cathode. Whereas only 70% of capacity retention is achieved for uncoated LiCoO2 after 25 cycles, 90% of capacity retention is observed for LiCoO2 with ALD Al2O3 layers. Electrochemical impedance spectroscopy (EIS) and transmission electron microscopy (TEM) studies show that the presence of ALD Al2O3 layers on the surface of LiCoO2 reduces interfacial resistance development between LiCoO2 and solid state electrolyte (SSE) during cycling.
Human–Machine Interface for Robotic Surgery and Stereotaxy (2008)

While considerable technology has been integrated into the operating room, until recently, the actual performance of surgery has seen relatively few changes, relying mainly on hand-eye coordination. This paper outlines the development and composition as well as the requirements and reasoning that lead to the human-machine interface on neuroArm, a telerobotic surgical system. A critical component of the system was the workstation, where information was provided to and received from the operator. The surgeon controls the robotic system using two force-feedback hand controllers based on visual information from a stereoscopic viewing device and two liquid crystal displays. Two touch screens allow the user to monitor and control the settings of the robot and to view and manipulate 3-D MR images. Audio feedback from the surgical site and the operating room staff is also provided by a wireless communication system. The workstation components were chosen not only to recreate the sight, sound, and touch of surgery but also to facilitate the integration of surgeons with advanced imaging and robotic technologies.
Fabrication of α-Sialon Nano-Ceramics (2006)

Y- α-sialon (m=1.35, n=0.675) ceramics were prepared by high-energy mechanical milling followed by spark plasma sintering. The milling promoted not only liquid-phase sintering, but also phase transformation from β-Si3N4 to α-sialon. Under the same holding time of 5 min, milled powder could be completely densified at 1500oC, which is about 250oC lower than that required for as-received powder. The temperature where the phase transformation finished was 1600oC and 1750oC for milled and as-received powder, respectively. The grain size of obtained dense ceramics from milled powder was significantly decreased. Nano-sized dense ceramics have been obtained by sintering the milled powder at 1500oC for 5 min. Although 100 % α-sialon has not been achieved, the nano-sized ceramics can be used for superplastic deformation, taking advantage of small grain size and large amount of transient liquid phase.
Response to Neoadjuvant Targeted Therapy in Operable Head and Neck Cancer Confers Survival Benefit (2023)

Brief neoadjuvant therapy achieved pathologic downstaging in a subset of patients and was associated with significantly better DFS and OS as well as decreased circulating methylated SOX17 and TAC1.
A toolkit for policy enablement in autonomic computing (2004)

Developers of policy enabled systems need a common set of basic functionality regardless of their areas of application. This is most conveniently provided in terms of a toolkit from which they can choose those components that are needed for their particular implementations. IBM T J Watson Research Center is developing such a policy toolkit in Java. The toolkit's goal is to accelerate the adoption of policy based technologies in different products and services. The policy toolkit (PTK) is written in Java and consists of a core module plus a set of modules that perform specific functions. The policy toolkit consists of a set of components for supporting the policy enablement of computer applications. As well as providing the necessary basic functionality, it also includes advanced capabilities like policy validation, transformation, and conflict resolution. It also provides patterns for building a variety of policy enabled systems. A number of engagements have been undertaken in order to assess the usefulness of the components provided, and determining what additional capabilities might be needed. We have found that the policy toolkit has made it easier and more convenient for software developers to incorporate policy-based technologies into their applications.
AFLP-based Detection of Adulterants in Crude Drug Preparations of the ‘Safed Musli’ Complex (2007)

Safed Musli is an important aphrodisiac herb, which forms an essential ingredient of the preparation of more than one hundred Ayurvedic formulations. It has been found to be an ideal aphrodisiac, with none of the negative side effects associated with the chemical-based products. Various plants belonging to the genera Chlorophytum and Asparagus have been in use as aphrodisiacs under the common name of ‘Safed Musli’ because of their white tuberous roots. An AFLP based experiment was carried out to differentiate the members of the ‘Safed Musli’ complex and resolve the authentication problem prevailing in the herbal drug market.
Supplemental Methods and References from An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy (2023)

&lt;p&gt;Supplemental Methods and References: Description of additional methods and procedures used in the study. Also includes Supplemental References.&lt;/p&gt;
Chromophore structure in bacteriorhodopsin's O640 photointermediate (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChromophore structure in bacteriorhodopsin's O640 photointermediateSteven O. Smith, Johannes A. Pardoen, Patrick P. J. Mulder, Bo. Curry, Johan Lugtenburg, and Richard MathiesCite this: Biochemistry 1983, 22, 26, 6141–6148Publication Date (Print):December 1, 1983Publication History Published online1 May 2002Published inissue 1 December 1983https://pubs.acs.org/doi/10.1021/bi00295a016https://doi.org/10.1021/bi00295a016research-articleACS PublicationsRequest reuse permissionsArticle Views271Altmetric-Citations131LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Short term elevation in dietary protein intake does not worsen insulin resistance or lipids in older adults with metabolic syndrome: a randomized-controlled trial (2017)

ClinicalTrials.gov Identifier: NCT02885935; This trial was registered retrospectively (Study start date, April 01, 2013, date of registration, August 26, 2016).
Role of CAAT/Enhancer Binding Protein Homologous Protein in Panobinostat-Mediated Potentiation of Bortezomib-Induced Lethal Endoplasmic Reticulum Stress in Mantle Cell Lymphoma Cells (2010)

These findings suggest that increased UPR and induction of CHOP are involved in enhanced anti-MCL activity of the combination of panobinostat and bortezomib.
ChemInform Abstract: Xanthic Anhydrides: A Novel and Convenient Source of Alkoxythiocarbonyl and Alkyl Radicals. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Gold nanostructures: synthesis, properties, and neurological applications (2022)

Recent advances in technology are expected to increase our current understanding of neuroscience. Nanotechnology and nanomaterials can alter and control neural functionality in both <i>in vitro</i> and <i>in vivo</i> experimental setups. The intersection between neuroscience and nanoscience may generate long-term neural interfaces adapted at the molecular level. Owing to their intrinsic physicochemical characteristics, gold nanostructures (GNSs) have received much attention in neuroscience, especially for combined diagnostic and therapeutic (theragnostic) purposes. GNSs have been successfully employed to stimulate and monitor neurophysiological signals. Hence, GNSs could provide a promising solution for the regeneration and recovery of neural tissue, novel neuroprotective strategies, and integrated implantable materials. This review covers the broad range of neurological applications of GNS-based materials to improve clinical diagnosis and therapy. Sub-topics include neurotoxicity, targeted delivery of therapeutics to the central nervous system (CNS), neurochemical sensing, neuromodulation, neuroimaging, neurotherapy, tissue engineering, and neural regeneration. It focuses on core concepts of GNSs in neurology, to circumvent the limitations and significant obstacles of innovative approaches in neurobiology and neurochemistry, including theragnostics. We will discuss recent advances in the use of GNSs to overcome current bottlenecks and tackle technical and conceptual challenges.
ChemInform Abstract: Quaternary Salts of 2‐((Hydroxyimino)methyl)imidazole. Part 5. Structure—Activity Relationships for Side‐Chain Nitro‐, Sulfone‐, Amino‐, and Aminosulfonyl‐Substituted Analogues for Therapy Against Anticholinesterase Intoxication. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Dietary phenolic acids attenuate multiple stages of protein glycation and high‐glucose‐stimulated proinflammatory IL‐1β activation by interfering with chromatin remodeling and transcription in monocytes (2010)

This study examined the effects of dietary phenolic acids on individual stages of protein glycation and utilized monocyte cultures to assess whether these phytochemicals modulate the activation of proinflammatory cytokine under high glucose (HG, 15 mmol/L) conditions mimicking diabetes. In vitro glycation assays showed that a number of phenolic acids exerted inhibitory effects on the glycation reaction and its subsequent crosslinking. Phenolic acids, especially methoxyphenolic acids, prevented increase in both levels of the interleukin-1beta (IL-1beta) and oxidative stress caused by HG. The effect appeared to be mediated by modulation of the protein kinase C/nuclear factor-kappaB axis. Chromatin immunoprecipitation demonstrated for the first time that HG increased the recruitment of nuclear factor-kappaB p65 and CREB-binding protein to the IL-1beta promoter. Interestingly, HG also increased histone acetylation and methylation within the IL-1beta promoter and decreased histone deacetylase activities in monocytes, thus facilitating chromatin remodeling and transcription. Such inappropriate inflammatory responses were found to be controlled effectively by treatment with methoxyphenolic compounds. In conclusion, this study suggests that phenolic acids could exert their anti-inflammatory activities as antiglycation agents and as modifiers of signaling pathways. It provides evidence for a novel mechanism by which phenolics supplementation might have additional protective effects against diabetic complications.