gebhart/patrepeval huggingface dataset:
Constant quality rate allocation for FGS coding using composite R-D analysis (2006)

In this correspondence, we propose a constant quality rate allocation algorithm for fine granularity scalability (FGS) coded videos. The rate allocation problem is formulated as a constrained minimization of quality fluctuation. The minimization is solved using a composite rate distortion (R-D) analysis. For a set of video frames, a composite R-D curve is first computed and then used for computing the optimal rate allocation. This algorithm is efficient because it is neither iterative nor recursive. After the composite R-D curve is computed, it can be used for optimal rate allocation of any rate budget. Moreover, the composite R-D curve can be updated efficiently over sliding windows. Experimental results have shown both the effectiveness and the efficiency of the proposed algorithm.
Safety, Biodistribution and Viral Shedding of Oncolytic Vaccinia Virus TG6002 Administered Intravenously in Healthy Beagle Dogs (2020)

Abstract Oncolytic virotherapy is an emerging strategy that uses replication-competent viruses to kill tumor cells. We have previously reported the oncolytic effects of TG6002, a novel recombinant oncolytic vaccinia virus, in various preclinical human xenograft models and canine tumor explants. To assess the safety, biodistribution and shedding of TG6002 administered by the intravenous route, we conducted a study in four immune-competent healthy dogs. Three dogs each received a single intravenous injection of TG6002 at 1 x 10 5 PFU/kg, 1 x 10 6 PFU/kg or 1 x 10 7 PFU/kg, and one dog received three intravenous injections at 1 x 10 7 PFU/kg. The injections were well tolerated without any clinical, hematological or biochemical adverse events. Viral genomes were only detected in blood one hour after injection. Post mortem analyses allowed detection of viral DNA in the spleen of one dog. Viral genomes were not detected in the urine, saliva or feces of any dogs. Seven days after the injections, a dose-dependent immune response was identified. In conclusion, intravenous administration of TG6002 shows a good safety profile, a finding that supports the initiation of clinical trials in canine cancer patients as well as further development of TG6002 as a human cancer therapy.
Abstract 18212: Von Willebrand Factor-ADAMTS13 System and Clinical Outcome in Patients With Non-valvular Atrial Fibrillation (2017)

Introduction: We previously documented a direct relationship between Von Willebrand factor (VWF) concentration/activity regulated by cleaving protease - ADAMTS13 and echocardiographic measures of l...
CD40 Agonist Targeted to Fibroblast Activation Protein α Synergizes with Radiotherapy in Murine HPV-Positive Head and Neck Tumors (2021)

Our study provides proof of concept, as well as mechanistic insights of the therapeutic efficacy of a bispecific FAP-CD40 combined with local radiotherapy in a FAP<sup>+</sup>-HNSCC model increasing overall survival and inducing long-term antitumor immunity.
Long-distance transmon coupler with CZ gate fidelity above $99.8\%$ (2022)

Tunable coupling of superconducting qubits has been widely studied due to its importance for isolated gate operations in scalable quantum processor architectures. Here, we demonstrate a tunable qubit-qubit coupler based on a floating transmon device which allows us to place qubits at least 2 mm apart from each other while maintaining over 50 MHz coupling between the coupler and the qubits. In the introduced tunable-coupler design, both the qubit-qubit and the qubit-coupler couplings are mediated by two waveguides instead of relying on direct capacitive couplings between the components, reducing the impact of the qubit-qubit distance on the couplings. This leaves space for each qubit to have an individual readout resonator and a Purcell filter needed for fast high-fidelity readout. In addition, the large qubit-qubit distance reduces unwanted non-nearest neighbor coupling and allows multiple control lines to cross over the structure with minimal crosstalk. Using the proposed flexible and scalable architecture, we demonstrate a controlled-$Z$ gate with $(99.81 \pm 0.02)\%$ fidelity.
A New Resveratrol Hexamer from Upuna borneensis (2004)

A new resveratrol hexamer, upunaphenol A, was isolated from an acetone soluble part of stem of Upuna borneensis (Dipterocarpaceae).The structure, which has twelve asymmetric carbon atoms on the partial structures of a dibenzobicyclo[3.2.1]octadiene ring and four dihydrobenzofuran rings, was determined by spectral analysis including 1D and 2D NMR spectral experiments.Resveratrol and four known resveratrol oligomers, ampelopsin F, isoampelopsin F, vaticanols C and B, were also isolated.Upunaphenol A was found to suppress cell growth in HL60 cells through induction of apoptosis with IC 50 at 9.2 mM.
Endoplasmic reticulum stress is a target for therapy in Waldenstrom macroglobulinemia (2008)

Waldenstrom macroglobulinemia (WM) is an incurable low-grade lymphoma characterized by bone marrow (BM) involvement of IgM secreting lymphoplasmacytic cells. The induction of unfolded protein response (UPR) genes ("physiologic" UPR) enables cells to differentiate into professional secretory cells capable of production of high amounts of endoplasmic reticulum (ER)-processed proteins, such as immunoglobulins. Ultimately, the initially cytoprotective UPR triggers an apoptotic cascade if ER stress is not corrected, called proapoptotic/terminal UPR. We show that WM cells inherently express the physiologic UPR machinery compared with normal BM cells, and that increased ER stress leads to proapoptotic/terminal UPR in WM cells. We therefore examined tunicamycin, ER stress inducer, for potential antitumor effects in WM. Tunicamycin induced significant cytotoxicity, apoptosis and cell-cycle arrest, and inhibited DNA synthesis in WM cell lines and primary BM CD19(+) cells from patients with WM with an inhibitory concentration (IC(50)) of 0.5 microg/mL to 1 microg/mL, but not in healthy donor cells. Importantly, coculture of WM cells in the context of the BM microenvironment did not inhibit tunicamycin-induced cytotoxicity. Finally, we demonstrate that ER stress inducer synergizes with other agents used in the treatment of WM. These preclinical studies provide a framework for further evaluation of ER stress inducing agents as therapeutic agents in WM.
Sub-nanosecond switching of a tantalum oxide memristor (2011)

We report sub-nanosecond switching of a metal-oxide-metal memristor utilizing a broadband 20 GHz experimental setup developed to observe fast switching dynamics. Set and reset operations were successfully performed in the tantalum oxide memristor using pulses with durations of 105 and 120 ps, respectively. Reproducibility of the sub-nanosecond switching was also confirmed as the device switched over consecutive cycles.
Supplementary Figure 1 from Amplification of MDS1/EVI1 and EVI1, Located in the 3q26.2 Amplicon, Is Associated with Favorable Patient Prognosis in Ovarian Cancer (2023)

Supplementary Figure 1 from Amplification of MDS1/EVI1 and EVI1, Located in the 3q26.2 Amplicon, Is Associated with Favorable Patient Prognosis in Ovarian Cancer
Oral Presentation : Pleanary Lecture ; 1PL-1 : Biologically inspired chemistry: From discovery to technological innovation (2015)

In the course of evolution, Nature has developed strategies that endow biological processes and materials with exquisite selectivity, specificity,and adaptability. This talk will discuss how understanding some of the basic principles of biological architectures can guide us in developing new, bio-inspired chemistries that lead to advanced materials. Examples of broad implications in fields ranging from architecture to energy efficiency to medicine will be presented, reflecting on what it takes to bridge the gap between discovery and technology development on the path to commercialization.
Nephrotic syndrome: an under‐recognised immune‐mediated complication of non‐myeloablative allogeneic haematopoietic cell transplantation (2005)

Nephrotic syndrome (NS) is an extremely rare complication of myeloablative allogeneic haematopoietic cell transplantation (HCT) that usually occurs in association with chronic graft-versus-host disease (C-GVHD). We observed an unexpectedly high incidence of NS in a cohort of 163 consecutive patients undergoing non-myeloablative HCT from a related human leucocyte antigen-compatible donor. Seven patients developed NS at a median 318 d post-transplant (range 119-1203 d; cumulative incidence 6.1%). The median age at onset of NS was 46 years (range 33-59 years); three of the seven patients had no evidence of C-GVHD while four had accompanying limited C-GVHD. At diagnosis, median proteinuria was 16.5 g/24 h (range 3-24 g/24 h). Renal biopsy was performed in four cases and revealed membranous nephropathy. NS was not always associated with other symptoms of C-GVHD, and in contrast to previous reports, usually did not improve with the re-initiation of aggressive immunosuppression, resulting in progressive renal failure necessitating dialysis in three of seven cases. Membranous nephropathy resulting in NS is a previously unrecognised and clinically significant complication of non-myeloablative HCT.
Mycobacterium avium Infection in a C3HeB/FeJ Mouse Model (2019)

Infections caused by <i>Mycobacterium avium</i> complex (MAC) species are increasing worldwide, resulting in a serious public health problem. Patients with MAC lung disease face an arduous journey of a prolonged multidrug regimen that is often poorly tolerated and associated with relatively poor outcome. Identification of new animal models that demonstrate a similar pulmonary pathology as humans infected with MAC has the potential to significantly advance our understanding of nontuberculosis mycobacteria (NTM) pathogenesis as well as provide a tractable model for screening candidate compounds for therapy. One new mouse model is the C3HeB/FeJ which is similar to MAC patients in that these mice can form foci of necrosis in granulomas. In this study, we evaluated the ability of C3HeB/FeJ mice exposure to an aerosol infection of a rough strain of MAC 2285 to produce a progressive infection resulting in small necrotic foci during granuloma formation. C3HeB/FeJ mice were infected with MAC and demonstrated a progressive lung infection resulting in an increase in bacterial burden peaking around day 40, developed micronecrosis in granulomas and was associated with increased influx of CD4<sup>+</sup> Th1, Th17, and Treg lymphocytes into the lungs. However, during chronic infection around day 50, the bacterial burden plateaued and was associated with the reduced influx of CD4<sup>+</sup> Th1, Th17 cells, and increased numbers of Treg lymphocytes and necrotic foci during granuloma formation. These results suggest the C3HeB/FeJ MAC infection mouse model will be an important model to evaluate immune pathogenesis and compound efficacy.
Light Confinement at Ultrasharp Metallic Tips (2008)

In this article, two alternative experimental strategies for reaching light confinement at metallic nanotips are discussed. The first approach utilizes optical field enhancement to localize nonlinear optical signals at the tip end. The second approach employs surface plasmon polaritons propagating coherently along the tip shaft and converging at its apex.
RETRACTED: Antimicrobial Photodynamic Inactivation in Nanomedicine: Small Light Strides Against Bad Bugs (2015)

The relentless advance of drug-resistance among pathogenic microbes, mandates a search for alternative approaches that will not cause resistance. Photodynamic inactivation (PDI) involves the combination of nontoxic dyes with harmless visible light to produce reactive oxygen species that can selectively kill microbial cells. PDI can be broad-spectrum in nature and can also destroy microbial cells in biofilms. Many different kinds of nanoparticles have been studied to potentiate antimicrobial PDI by improving photosensitizer solubility, photochemistry, photophysics and targeting. This review will cover photocatalytic disinfection with titania nanoparticles, carbon nanomaterials (fullerenes, carbon nanotubes and graphene), liposomes and polymeric nanoparticles. Natural polymers (chitosan and cellulose), gold and silver plasmonic nanoparticles, mesoporous silica, magnetic and upconverting nanoparticles have all been used for PDI.
Primary sclerosing cholangitis and recognitionof bile duct cancer: problem solved? (2006)

Comment
Tumor and microenvironment response but no cytotoxic T-cell activation in classic Hodgkin lymphoma treated with anti-PD1 (2020)

Classic Hodgkin lymphoma (cHL) is the cancer type most susceptible to antibodies targeting programmed cell death protein 1 (PD1) and is characterized by scarce Hodgkin and Reed-Sternberg cells (HRSCs), perpetuating a unique tumor microenvironment (TME). Although anti-PD1 effects appear to be largely mediated by cytotoxic CD8+ T cells in solid tumors, HRSCs frequently lack major histocompatibility complex expression, and the mechanism of anti-PD1 efficacy in cHL is unclear. Rapid clinical responses and high interim complete response rates to anti-PD1 based first-line treatment were recently reported for patients with early-stage unfavorable cHL treated in the German Hodgkin Study Group phase 2 NIVAHL trial. To investigate the mechanisms underlying this very early response to anti-PD1 treatment, we analyzed paired biopsies and blood samples obtained from NIVAHL patients before and during the first days of nivolumab first-line cHL therapy. Mirroring the rapid clinical response, HRSCs had disappeared from the tissue within days after the first nivolumab application. The TME already shows a reduction in type 1 regulatory T cells and PD-L1+ tumor-associated macrophages at this early time point of treatment. Interestingly, a cytotoxic immune response and a clonal T-cell expansion were not observed in the tumors or peripheral blood. These early changes in the TME were distinct from alterations found in a separate set of cHL biopsies at relapse during anti-PD1 therapy. We identify a unique very early histologic response pattern to anti-PD1 therapy in cHL that is suggestive of withdrawal of prosurvival factors, rather than induction of an adaptive antitumor immune response, as the main mechanism of action.
Solid State Modulator for Plasma Channel Drilling (2008)

In addition to conventional mechanical and explosive drilling and demolition, drilling based on the use of pulsed electric power has been investigated intensively and recently commercial applications begin to emerge. With this method, the demolition of the rock is either performed by sonic impulses due to pulse discharges in water or by discharges directly through the rock, called plasma channel drilling (PCD). Due to the direct impact, the PCD method is more efficient. It is based on the fact that for very fast pulse rise times (<200-500 ns) the breakdown field strength of water is higher than that of rock, so that the discharge takes place in the rock. In the publications dealing with this topic plasma dynamics, the crack formation and the setup of the electrodes are mostly studied. There, modulators based on spark gaps either as single switch or in a Marx generator are utilised for generating the high voltage pulse. These modulators are basically able to generate high voltages and high currents at the same time. However, the PCD method requires the high voltage just for igniting the discharge. After the ignition the voltage across the arc is relatively small. Therefore, these modulators are basically oversized. Furthermore, the life time of the spark gaps and their reliability is limited. Therefore, a solid state modulator, which generates a high voltage pulse for ignition and thereafter a high output current, is presented in this paper. This modulator consists of a single semiconductor switch, saturable inductors and a pulse transformer.
Development and Validation of a Chromatographic Ultraviolet Method for the Simultaneous Quantification of Dolutegravir and Rilpivirine in Human Plasma (2016)

The high-performance liquid chromatography-ultraviolet method we developed showed a good analytical performance required for therapeutic drug monitoring of antiretrovirals, leading to potential improvements in HIV-infected patient care and laboratory management.
Effects of lipid emulsions on unbound bilirubin and response to phototherapy in preterm infants (2022)

IL and SMOF both increase Bf similarly, and phototherapy does not significantly affect Bf for infants receiving them.
Increasing use of allogeneic hematopoietic cell transplantation in patients aged 70 years and older in the United States (2017)

In this study, we evaluated trends and outcomes of allogeneic hematopoietic cell transplantation (HCT) in adults ≥70 years with hematologic malignancies across the United States. Adults ≥70 years with a hematologic malignancy undergoing first allogeneic HCT in the United States between 2000 and 2013 and reported to the Center for International Blood and Marrow Transplant Research were eligible. Transplant utilization and transplant outcomes, including overall survival (OS), progression-free survival (PFS), and transplant-related mortality (TRM) were studied. One thousand one hundred and six patients ≥70 years underwent HCT across 103 transplant centers. The number and proportion of allografts performed in this population rose markedly over the past decade, accounting for 0.1% of transplants in 2000 to 3.85% (N = 298) in 2013. Acute myeloid leukemia and myelodysplastic syndromes represented the most common disease indications. Two-year OS and PFS significantly improved over time (OS: 26% [95% confidence interval (CI), 21% to 33%] in 2000-2007 to 39% [95% CI, 35% to 42%] in 2008-2013, <i>P</i> < .001; PFS: 22% [16% to 28%] in 2000-2007 to 32% [95% CI, 29% to 36%] in 2008-2013, <i>P</i> = .003). Two-year TRM ranged from 33% to 35% and was unchanged over time (<i>P</i> = .54). Multivariable analysis of OS in the modern era of 2008-2013 revealed higher comorbidity by HCT comorbidity index ≥3 (hazard ratio [HR], 1.27; <i>P</i> = .006), umbilical cord blood graft (HR, 1.97; <i>P</i> = .0002), and myeloablative conditioning (HR, 1.61; <i>P</i> = .0002) as adverse factors. Over the past decade, utilization and survival after allogeneic transplant have increased in patients ≥70 years. Select adults ≥70 years with hematologic malignancies should be considered for transplant.
Injection locked oscillator arrays for spectrum analysis (2009)

Injection locked oscillator arrays are described as a means of quasi-real-time spectrum analysis. Two oscillators with closely spaced frequencies at 5.1 and 5.8 GHz were designed such that single or simultaneous injection locking may occur depending on the injected frequency and power. The locking range for a -20 dBm input is greater than 150 MHz for each oscillator and at 0 dBm the oscillators share a locking range greater than 500 MHz. Isolation higher than 14 dB was measured between both oscillators under maximum injection conditions. Injection sensitivity, isolation, and phase noise characteristics are described and measured. Single or simultaneous injection locking of two neighboring oscillators is illustrated in a 0.12 mum SiGe BiCMOS process using only NMOS devices.
TG-FTIR Study of the Influence of Potassium Chloride on Wheat Straw Pyrolysis (1998)

The interest in utilizing biomass as a CO2 neutral fuel by combustion, gasification, or pyrolysis processes is increasing due to concern about the emission of greenhouse gases from fossil fuel combustion. In thermal fuel conversion, pyrolysis is an important step which determines the split of products into char, tar, and gas. In this work, a combination of thermogravimetry and evolved gas analysis by Fourier transform infrared analysis (TG-FTIR) has been applied to study the influence of potassium chloride (KCl) on wheat straw pyrolysis. Raw straw, washed straw, and washed straw impregnated with KCl have been investigated. To facilitate interpretation of the results, pyrolysis of biopolymers (cellulose, xylan, lignin) in the presence and absence of KCl was investigated as well. The raw straw decomposed in a single broad featureless peak. By washing, two peaks appeared in the derivative weight loss curve, corresponding to the decomposition of hemicellulose and cellulose components in the straw. Washing reduced the char yield from 23 wt % (daf) to 12 wt % (daf), reduced the yields of gases, and increased the tar yield from 32 wt % (daf) to 66 wt % (daf). Adding 2 wt % (daf) KCl to the washed straw resulted in a char yield which was close to that of the raw straw, and the yields of tar and gases were between those from the raw and washed straw. Furthermore, the peaks corresponding to hemicellulose and cellulose decomposition moved to lower temperatures, from 670 to 633 K for the cellulose peak, but did not collapse to a single peak as in the raw straw. The influence of KCl on the peak temperature of hemicellulose and cellulose decomposition was not observed with the single biopolymers. This indicates that minerals in straw influence the interaction between the biopolymers in whole biomass. Combustion of the char remaining after pyrolysis showed that char combustion is catalyzed by the minerals present in wheat straw. Char from the washed straw with KCl added burned with two peaks in the derivative weight loss curve corresponding to a catalyzed and noncatalyzed part, indicating that the added salt did not behave in the same way as the inherent minerals in the straw.
Orthotopic Ferret Tracheal Transplantation Using a Recellularized Bioengineered Graft Produces Functional Epithelia (2023)

Tracheal grafts may be necessary to bridge long-segment defects after curative resection for airway obstructions. Bioengineered grafts have emerged as an appealing option, given the possibilities of altering the histologic and cellular profile of the conduit. We previously designed a bioreactor capable of luminally decellularizing and recellularizing a ferret trachea with surface airway epithelia (SAE) basal cells (BCs), and we sought to assess the fate of these grafts when transplanted in an orthotopic fashion. As adjuncts to the procedure, we investigated the use of a vascular endothelial growth factor (VEGF)-laden hydrogel and of immunosuppression (IS) in graft revascularization and viability. IS was shown to limit early graft revascularization, but this effect could be counteracted with VEGF supplementation. Submucosal gland (SMG) loss was shown to be inevitable regardless of the revascularization strategy. Lastly, the bioengineered tracheas survived one month after transplant with differentiation of our implanted BCs that then transitioned into a recipient-derived functional epithelium. The work presented in this manuscript has important implications for future cellular and regenerative therapies.