gebhart/patrepeval huggingface dataset:
Defining Remission Using Patient-reported Outcome Components of the Crohnʼs Disease Activity Index: Post-hoc Analyses of Vedolizumab Data from the GEMINI 2 Study (2015)

Introduction: Clinical trials in Crohn's disease (CD) are evolving toward including patient (pt)-reported outcomes (PROs) to evaluate drug efficacy; however, no validated PROs are available. In post hoc analyses of data from the GEMINI 2 study,1 we evaluated different definitions of vedolizumab (VDZ)-induced remission using PRO components of the CD Activity Index (CDAI).Table 1: Definitions of RemissionMethods: Pts with moderately to severely active CD (CDAI 220-450) who responded to 6 weeks (wks) of VDZ induction therapy were re-randomized to maintenance therapy with placebo (PBO) or VDZ for 46 wks. CDAI stool frequency (SF), abdominal pain (AP), and general well-being (GWB) subscores were evaluated alone and in combination (PRO-2 [SF + AP] and PRO-3 [SF + AP + GWB]) at wks 0, 6, and 52, and their contributions to baseline and mean change from baseline CDAI total scores were analyzed. The sensitivity of PRO-based remission—defined by unweighted combined daily (PRO-2 [SF ≤3 + AP ≤1]) and weighted 7-day (PRO-2 ≤75 or PRO-3 ≤80) mean scores—to detect clinical remission (CDAI =150), their agreement with CDAI ≤150, and the percentage of GEMINI 2 pts who met PRO-based entry criteria (SF ≥4 and/or AP ≥2) were evaluated. Results: The SF, AP, and GWB subscores contributed 25%, 21%, and 31%, respectively, to the mean baseline CDAI score. PRO-2 and PRO-3 accounted for, respectively, 53% and 91% of the mean change from baseline CDAI score at wk 6, and 47% and 82% at wk 52. The PRO-based definition with the best agreement with CDAI remission at wk 6 was PRO-3 ≤80 and at wk 52 was PRO-2 ≤75 (Table). PRObased entry criteria of SF ≥4 and/or AP ≥2 were met by 86% of GEMINI 2 pts; 42% of patients had both SF ≥4 and AP ≥2. Conclusion: Of CDAI components, the PROs contributed most to baseline and treatment-induced changes in CDAI score. Different PRO-based definitions of remission (PRO-2 ≤75 or PRO-3 ≤80) had the best agreement with clinical remission at wks 6 and 52. Interpretations of these post hoc analyses are limited, but applying cutoffs used here to other data sets could clarify the reliability and clinical meaningfulness of PROs as outcome measures.
Reciprocal Learning for Energy-Eﬃcient Opportunistic Spec- trum Access in Cognitive Radio Networks (2012)

Recently, there has been extensive research on cognitive radio (CR) which bridges the enormous gulf in time and space between the regulation and the potential spectrum eﬃciency ( [1-3] and the references therein). One of the critical challenges is how to realize the coexistence of primary users (PUs) and cognitive users (CUs) accessing the same part of the authorized spectrum. The PUs have priority in accessing the frequency bands while the CUsFundamentals,opportunistically transmit when the spectrum is idle, as illustrated in Figure 5.1. To avoid colliding with the licensed network, the CUs must sense before transmission to determine whether there are PUs over the selected channel. However, the PUs’ stochastic behavior patterns challenge the selection process.
Surface‐Functionalization‐Mediated Direct Transfer of Molybdenum Disulfide for Large‐Area Flexible Devices (2018)

Abstract The transfer of synthesized large‐area 2D materials to arbitrary substrates is expected to be a vital step for the development of flexible device fabrication processes. The currently used hazardous acid‐based wet chemical etching process for transferring large‐area MoS 2 films is deemed to be unsuitable because it significantly degrades the material and damages growth substrates. Surface energy‐assisted water‐based transfer processes do not require corrosive chemicals during the transfer process; however, the concept is not investigated at the wafer scale due to a lack of both optimization and in‐depth understanding. In this study, a wafer‐scale water‐assisted transfer process for metal–organic chemical vapor‐deposited MoS 2 films based on the hydrofluoric acid treatment of a SiO 2 surface before the growth is demonstrated. Such surface treatment enhances the strongly adhering silanol groups, which allows the direct transfer of large‐area, continuous, and defect‐free MoS 2 films; it also facilitates the reuse of growth substrate. The developed transfer method allows direct fabrication of flexible devices without the need for a polymeric supporting layer. It is believed that the proposed method can be an alternative defect‐ and residue‐free transfer method for the development of MoS 2 ‐based next‐generation flexible devices.
Bell Peppers (Capsicum annuum) Express Allergens (Profilin, Pathogenesis-Related Protein P23 and Bet v 1) Depending on the Horticultural Strain (1998)

The appearance of profilin in all and Bet v 1 in 50% of the tested horticultural strains indicates that bell peppers have to be considered potentially dangerous for Bet v 1- and profilin-sensitized patients. Moreover, in 4 of 8 horticultural strains of bell peppers a homologue of the osmotin-like protein P23 from tomatoes is responsible for substantial IgE binding. Contact with Bet v 1 and P23 homologues in bell peppers can therefore be minimized by avoidance of the respective horticultural strains.
HyTER: Meaning-Equivalent Semantics for Translation Evaluation (2012)

It is common knowledge that translation is an ambiguous, 1-to-n mapping process, but to date, our community has produced no empirical estimates of this ambiguity. We have developed an annotation tool that enables us to create representations that compactly encode an exponential number of correct translations for a sentence. Our findings show that naturally occurring sentences have billions of translations. Having access to such large sets of meaning-equivalent translations enables us to develop a new metric, HyTER, for translation accuracy. We show that our metric provides better estimates of machine and human translation accuracy than alternative evaluation metrics.
Duration of Nuclear NF-κB Action Regulated by Reversible Acetylation (2001)

The nuclear expression and action of the nuclear factor kappa B (NF-kappaB) transcription factor requires signal-coupled phosphorylation and degradation of the IkappaB inhibitors, which normally bind and sequester this pleiotropically active factor in the cytoplasm. The subsequent molecular events that regulate the termination of nuclear NF-kappaB action remain poorly defined, although the activation of de novo IkappaBalpha gene expression by NF-kappaB likely plays a key role. Our studies now demonstrate that the RelA subunit of NF-kappaB is subject to inducible acetylation and that acetylated forms of RelA interact weakly, if at all, with IkappaBalpha. Acetylated RelA is subsequently deacetylated through a specific interaction with histone deacetylase 3 (HDAC3). This deacetylation reaction promotes effective binding to IkappaBalpha and leads in turn to IkappaBalpha-dependent nuclear export of the complex through a chromosomal region maintenance-1 (CRM-1)-dependent pathway. Deacetylation of RelA by HDAC3 thus acts as an intranuclear molecular switch that both controls the duration of the NF-kappaB transcriptional response and contributes to the replenishment of the depleted cytoplasmic pool of latent NF-kappaB-IkappaBalpha complexes.
COMMENT (2001)

RETURN TO ISSUEPREVACS NewsNEXTCOMMENTCHEMRAWN XIV, CONGRESS ON GREEN CHEMISTRYDARYLE H. BUSCHCite this: Chem. Eng. News 2001, 79, 20, 61Publication Date (Print):May 14, 2001Publication History Published online16 November 2010Published inissue 14 May 2001https://pubs.acs.org/doi/10.1021/cen-v079n020.p061https://doi.org/10.1021/cen-v079n020.p061acs-newsACS PublicationsCopyright © 2001 American Chemical Society. This publication is available under these Terms of Use. This publication is free to access through this site. Learn MoreArticle Views74Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (552 KB) SUBJECTS:Green chemistry Get e-Alerts
Generalized correlations for the estimation of condensate power in flooded cylinders (2013)

Condensate accumulated inside dryer cylinders will produce an increased power demand and eventually the inability of the dryer drive to accelerate the section. In a previous paper these authors presented an online estimation algorithm capable of detecting the presence of condensate during a section starting. In this paper a complete set of tests is run over two experimental cylinders covering up to 40% of cylinder volumes and the complete set of power curves are reported and analyzed. Specifically, the presence of a combined cascading - rimming region in the medium to high condensate loads is confirmed. This combined mode modifies the pattern followed by the maximum power in the low condensate region. Using this data, high-order and simplified correlations are proposed for the estimation of condensate in flooded dryer cylinders. These new correlations increase the capacity of the online estimation algorithm to give good estimations of the condensate load present inside the dryer cylinders up to 55 mm of rim thickness.
Preclinical assessment of PM21-particle expanded natural killer cells for ovarian cancer treatment. (2017)

127 Background: Ovarian cancer has high recurrence rate and could benefit from immunotherapy with NK cells. A necessity for NK cell therapy is an efficient way to generate high doses of NK cells. The best method currently used in clinical trials is ex vivo NK cell expansion by co-culture with K562 CML cells, modified to express 41-BBL and membrane bound IL21 (K562.mb21). However feeder cell based methods are limited to ex vivo co-culture, difficult to disseminate, and not allowed in many jurisdictions. To overcome these limitations and to further improve NK cell therapy, we developed a feeder cell free particle based method for NK cell stimulation. These particles (PM21) are nano-scale, made from cell membranes of K562.mb21 cells, and efficiently stimulate NK cell expansion (mean 825 fold in 14 days, range 163–2216, n = 13). Methods: PM21 particles were prepared from K562.mb21 cells with a procedure developed by our group. NK cells were expanded by culturing CD3 depleted PBMCs with PM21 particles or by co-culture with K562.mb21 cells for 14 days as previously described. NSG mice ( ≥ 8 per group) were implanted ip with 1 x 10 6 SKOV3 ovarian tumor cells, seeded 8 days, and then treated with vehicle or NK cells expanded with PM21 or K562.mb21 cells (two doses of 10 x 10 6 , injected 6 days apart), with or without in vivo administration of PM21 particles (600 µg, 3x weekly), and IL2 (25 KU, 3x weekly), all delivered ip. Survival analysis was performed with log rank (Mantel-Cox) test. Results: Treatment of SKOV3 engrafted NSG mice with NK cells, expanded with K562.mb21 cells or with PM21 particles, allowed significant ( &lt; 0.0001) 10 day increase in survival compared to untreated animals that succumbed on average 21 days after start of treatment. Administration of ip PM21 particles enhanced survival by 5 days (p = 0.056) over no in vivo PM21 groups. Conclusions: NK cells prepared with PM21 particles or with K562.mb21 cells are equivalent in anti-SKOV3 efficacy and in vivo application of PM21 particles provides further benefit. Clinical translation is underway and clinical trials are being planned. PM21 particles can be the next step in development of NK cell therapy for enhancing both efficacy and dissemination of NK cell therapeutics for ovarian cancer.
A unifying mechanism for stimulation of mammalian pyruvate dehydrogenase(a) kinase by reduced nicotinamide adenine dinucleotide, dihydrolipoamide, acetyl coenzyme A, or pyruvate. (1978)

Marked increases in the rates of phosphorylation and inactivation of the pyruvate dehydrogenase complex by pyruvate dehydrogenase, (PDH,) kinase can be induced by NADH, acetyl-coenzyme A or, under certain conditions, pyruvate.Our results support the hypothesis that reduction (by NADH) or acetylation (by acetyl-CoA or pyruvate) of the lipoyl moiety of the dihydrolipoyl transacetylase component of the complex is required for stimulation of the PDH, kinase activity by these effecters.NADH and free dihydrolipoamide give half-maximal stimulation of PDH, kinase activity at about 4 and 7 PM, respectively.Consistent with a common mechanism for stimulation by these effecters, a combination of 50 PM NADH and 50 FM dihydrolipoamide gives no additional stimulation beyond either added individually at the same concentration.At a concentration of 50 PM, NADH or dihydrolipoamide facilitates acetyl-CoA stimulation, which does not occur in the absence of a reducing compound.At the same thiol concentration, dithiothreitol, dithioerythritol, or /3-mercaptoethanol fail either to stimulate PDH, kinase activity or to facilitate acetyl-CoA stimulation.Dihydrolipoamide (50 FM) stimulates PDH, kinase activity when added in addition to a IO-fold higher concentration of these other thiol compounds.Thus, the effects of dihydrolipoamide on PDH, kinase activity are very specific and closely parallel NADH stimulation and NADH-facilitated acetyl-CoA stimulation of PDH, kinase activity.Depending on conditions, pyruvate either stimulates or inhibits PDH, kinase activity.Acetyl-CoA and low pyruvate concentrations stimulate PDH, kinase activity to about the same level and the combination of pyruvate an.d acetyl-CoA gives no additional stimulation.Acetyl-CoA and pyruvate have parallel salt dependence with greater than 20 mM KC1 required to detect stimulation by either.These results are consistent with a common mechanism for stimulation of
A sequential two-stage dose escalation study of eltrombopag in patients with myelodysplastic syndrome and thrombocytopenia after hypomethylating agent failure (2020)

Thrombocytopenia occurs frequently in patients with myelodysplastic syndromes (MDS), and the survival of patients after failure of hypomethylating agents (HMAs) is poor. We conducted a trial of eltrombopag in patients with MDS, MDS/myeloproliferative neoplasm (MPN) or acute myeloid leukemia (AML) with 20-30% myeloblasts after HMA failure and mean baseline platelet count ≤ 50 × 10<sup>9</sup>/L. Eltrombopag was escalated from 50 mg daily up to 200 mg daily. The primary objective was to determine the maximally tolerated dose (MTD). 37 patients were enrolled, and MTD was not reached. Responses were observed in 9 patients (24%), 2 achieving marrow CR with hematologic improvement (HI), 1 marrow CR without HI, and 6 HI. Median overall survival was 7.5 months. Eltrombopag was well-tolerated and yielded modest responses in heavily treated, predominantly higher-risk MDS patients after HMA failure. Future studies should focus on determining characteristics that predict response.
Fast and accurate mobile-aided screening system of moderate diabetic retinopathy (2021)

The Diabetic Retinopathy (DR) is a worldwide eye disease that causes visual damages and can leads to blindness. Therefore, the detection of the DR in the early stages is highly recommended. However, a delay is registered for ensuring early DR diagnosis which caused by the low-rate of the ophthalmologists, the deficiency of diagnosis equipment and the lack of mobility of elderly patients. In this paper, the main objective is to provide a mobile-aided screening system of moderate DR. Within this aim, we propose a classifier-based method which is based on detecting the Hard Exudate (HE) lesions that occur in moderate DR stage. A set of features are extracted to ensure an accurate and robust detection with respect to modest quality of fundus images. Moreover, the detection is provided in a low complexity processing to be suitable for mobile device. The aimed system corresponds to the implementation of the method on a smartphone associated to an optical lens for capturing fundus image. The system reached satisfactory screening performance where an accuracy of 98.36%, a sensitivity of 100% and specificity of 96.45% are registered using the DIARETDB1 fundus image databases. Moreover, the screening is performed in an average execution time of 2.68 seconds.
Influence of ultrasonic irradiation on ozone generation in a dielectric barrier discharge (2012)

An atmospheric pressure dielectric barrier discharge (DBD) was generated in an N2/O2 gas mixture at room temperature with and without ultrasonic irradiation to investigate ozone production. Powerful ultrasonic irradiation with the sound pressure level of approximately 150 dB into the DBD can enhance ozone production especially when the DBD was driven at a frequency of 15 kHz.
Sphingosine‐1‐phosphate lyase is expressed by CD68+ cells on the parenchymal side of marginal reticular cells in human lymph nodes (2014)

Lymph nodes (LNs) form the intersection between the vascular and lymphatic systems. Lymphocytes and antigen-presenting cells (APCs) traffic between these systems, but the barriers crossed during this trafficking in human LNs are poorly defined. We identified a population of cells in human LNs that lines the boundary between the parenchyma and lymphatic sinuses, consistent with descriptions of marginal reticular cells (MRCs) in murine LNs. Human MRCs are CD141(high) podoplanin(+), CD90(+), ICAM1(+), and VCAM1(+) but lack endothelial and hematopoietic cell markers, or alpha-smooth muscle actin. We then examined expression of the enzyme sphingosine-1-phosphate (S1P) lyase (SGPL1) relative to the boundary defined by MRCs. SGPL1 expression was almost exclusively restricted to cells on the parenchymal side of MRCs, consistent with a role in maintaining the S1P gradient between the sinuses and the parenchyma. Surprisingly the cells expressing SGPL1 in the parenchyma were CD68(+) APCs. CD68(+) APCs generated from human monocytes were able to internalize and irreversibly degrade S1P, and this activity was inhibited by the S1P analogue FTY720. This work provides a map of the key structures at the boundary where human lymphocytes egress into sinuses, and identifies a novel potential mechanism for the activity of S1P analogues in humans.
Abstract 1214: Single nucleotide polymorphism in HER family members increases susceptibility to human invasive cervical cancer (2011)

Abstract Cervical cancer is the second-most common cancer among women worldwide (Parkin et al. 1999). Some studies address prognostic roles that different genes play after the development of cervical cancer. However, there is a lack of studies addressing polymorphisms in genes of normal tissues that influence susceptibility to cervical cancer prior to malignant transformation. Such studies could be pivotal in prevention and timely diagnosis. It is well-known that Human Papillomavirus (HPV) infection appears to be the primary causative factor for cervical cancer, but host factors must be crucial since only a fraction of HPV-infected women develop cervical cancer. HPV antigens are the ligands of HER family members, and the E5 protein may play a role in the early stage of HPV infection before transformation. Thus, we studied whether there are excessive parent-to-offspring transmissions of specific HER SNP variants in EGFR, ERBB2, ERBB3 and ERBB4, in cases of invasive cervical cancer (ICC) or cervical intraepithelial neoplasia grade 3 (CIN3). Based on single SNP TDT tests, we identified a significant association between ICC/CIN3 and rs11770506, which is located at intron1 of EGFR and in high linkage disequilibrium (LD) with multiple enhancers. Our study provides clues for the identification of vulnerable populations and will advance the development of early detection of ICC in appropriate populations. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1214. doi:10.1158/1538-7445.AM2011-1214
A 12-GHz, 12-W HJFET amplifier with 48% peak power-added efficiency (1995)

This letter describes a Ku-band power amplifier fabricated with a one-chip 0.45 μm×16.8 mm GaAs-based heterojunction FET (HJFET), in which a 40.9 dBm (12.3 W) output power with 48% power-added efficiency (PAE) and 10.1 dB linear gain was achieved at 12 GHz. To our knowledge, this is the highest PAE, gain and output power combination achieved by a single FET power amplifier at this frequency.
Single-cell RNA-seq identifies the neuropeptide NMU as a novel regulator of ILC2 function (2018)

Abstract Type 2 innate lymphoid cells (ILC2s) are important for both mucosal homeostasis as well as for initiation and progression of allergy and asthma. Alarmin cytokines produced by damaged or stressed epithelial cells activate ILC2s, however, the role of other pathways regulating the homeostatic versus inflammatory functions of ILC2s remain poorly defined. We generated transcriptional profiles of thousands of lung-resident ILCs isolated from mice challenged with either PBS or the alarmin cytokines IL-25 or IL-33 using massively parallel droplet-based single-cell RNA sequencing (scRNA-seq). We found significant transcriptional heterogeneity within activated ILCs and identified differentially expressed genes as potential novel regulators of ILC function. One of the genes, neuromedin U receptor 1 (NMUR1), is a receptor for the neuropeptide neuromedin U (NMU) and is specifically expressed by ILC2s and not by other immune cells. Nmur1 is particularly expressed by ILC2s at steady-state and after IL-25 treatment. In vivo NMU synergized with IL-25 to induce more severe airway inflammation than was seen with either IL-25 or NMU alone and this effect was dependent on ILCs. Mechanistically, IL-25 + NMU expanded highly proliferative and inflammatory ILCs with distinct transcriptional profiles and increased expression of IL-5 and IL-13. We observed reduced ILC2 frequency and function in NMU- or NMUR1-deficient mice after allergen challenge and found that ILCs from these mice had a lower score for an inflammatory ILC2 gene signature. Our data therefore establish a novel neuro-immune pathway that amplifies ILC2-driven airway inflammation.
P‐174: Improved Operation Lifetime of Highly Efficient Sky‐Blue TADF OLEDs using Hexaphenylbenzene‐based Hole‐transporters (2019)

We successfully develped highly efficient 5TCzBN‐based sky‐blue TADF OLEDs exhibiting maximum external quantum efficiency (EQE) of 21.6 % and operation lifetime at 50 % (LT 50 ) of approximately 1,800 hours at an initial luminance of 500 cd m –2 . Here, novel hexaphenylbenzene‐based sterically bulky hole‐transporters named 4DBTHPB and 4DBFHPB with deep I p of –5.8 eV and high E T of 2.7 eV were used to improve the operation lifetime.