gebhart/patrepeval huggingface dataset:
Software Engineering with Microsoft Visual Studio Team System (2006)

About the Author xvii Foreword xix Preface xxi Acknowledgments xxix CHAPTER 1 A Value-Up Paradigm 1 CHAPTER 2 Value-Up Processes 27 CHAPTER 3 Requirements 49 CHAPTER 4 Project Management 79 CHAPTER 5 Architectural Design 115 CHAPTER 6 Development 133 CHAPTER 7 Testing 165 CHAPTER 8 Reporting Bugs 205 CHAPTER 9 Troubleshooting the Project 221 CHAPTER 10 Conclusion 243 Index 249
Expression of surface markers on the human monocytic leukaemia cell line, THP‐1, as indicators for the sensitizing potential of chemicals (2009)

By evaluating the expression patterns of CD54, CD86, and CD40, we could classify the chemicals as sensitizers or non-sensitizers, but CD80 and CD83 showed non-specific patterns of expression. These data suggest that the THP-1 cells are good model for screening contact sensitizers and CD40 could be a useful marker complementary to CD54 and CD86.
Randomized P hase I II S tudy o f T emozolomide V ersus Dacarbazine i n t he T reatment o f P atients W ith A dvanced Metastatic M alignant M elanoma (2000)

Purpose: To compare, in 305 patients with advanced metastatic melanoma, temozolomide and dacarbazine (DTIC) in terms of overall survival, progression-free survival (PFS), objective response, and safety, and to assess health-related quality of life (QOL) and pharmacokinetics of both drugs and their metabolite, 5-(3methyltriazen-1-yl)imidazole-4-carboximide (MTIC). Patients and Methods: Patients were randomized to receive either oral temozolomide at a starting dosage of 200 mg/m 2 /d for 5 days every 28 days or intravenous (IV) DTIC at a starting dosage of 250 mg/m 2 /d for 5 days every 21 days. Results: In the intent-to-treat population, median survival time was 7.7 months for patients treated with temozolomide and 6.4 months for those treated with DTIC (hazards ratio, 1.18; 95% confidence interval [CI], 0.92 to 1.52). Median PFS time was significantly longer in the temozolomide-treated group (1.9 months) than in the DTIC-treated group (1.5 months) (P 5 .012; hazards ratio, 1.37; 95% CI, 1.07 to 1.75). No major difference in drug safety was observed. Temozolomide was well tolerated and produced a noncumulative, transient myelosuppression late in the 28-day cycle. The most common nonhematologic toxicities were mild to moderate nausea and vomiting, which were easily managed. Temozolomide therapy improved health-related QOL; more patients showed improvement or maintenance of physical functioning at week 12. Systemic exposure (area under the curve) to the parent drug and the active metabolite, MTIC, was higher after treatment with oral temozolomide than after IV administration of DTIC. Conclusion: Temozolomide demonstrates efficacy equal to that of DTIC and is an oral alternative for patients with advanced metastatic melanoma. J Clin Oncol 18:158-166. © 2000 by American Society of Clinical Oncology.
Orthopaedic Infection: Prevention and Diagnosis (2016)

Host optimization, reduction of bacteria, and establishing proper wound environment in the preoperative, intraoperative, and postoperative periods are the traditional cornerstones of infection prevention. Most institutions have standardized a systems approach to reduce the incidence of surgical site infections. Typically, these systems-based approaches promote protocols for hand and environmental hygiene, patients risk assessment and screening, surgical delays for identifiable and modifiable risk factors, infection surveillance, antibiotic stewardship programs, communication/coordination of care, physician 360° reporting, and unit-based safety programs. Despite the institution of these prevention efforts, there remains controversy about the efficacy and cost-effectiveness of a number of these approaches.
Rewritable Printing System Using Leuco Dyes (2004)

Printing systems that are capable of displaying information are becoming increasing important as greater volumes of information become available in digital format. But considering that most documents are only printed for temporary use then discarded, a rewritable printing system would be useful and advantageous for the environment. We have now succeeded in developing a practical rewritable printing system that is capable of rewriting the same sheets more than 500 times. By thermally controlling the coloring reaction of leuco dyes, the system creates stable, highcontrast color images that can be quickly erased so the sheets can be reused and overwritten with new images. This is made possible by our ability to control molecular aggregation structures formed by long-chain molecules in leuco dye developer, which opened the way to our development of functional reversible media based on the supramolecular structure of leuco dye and the long-chain developer.
Reduction in pain scores and improvement in depressive symptoms in patients with hidradenitis suppurativa treated with adalimumab in a phase 2, randomized, placebo-controlled trial (2016)

Patients with moderate to severe HS had a high degree of pain and depressive symptoms at baseline. Adalimumabtherapy was associated with decreased pain and depressive symptoms compared to baseline.
Spin-exchange cross section for electron excitation of Na3S−3Pdetermined by a novel spectroscopic technique (1988)

An experimental technique is described which enables determination of the partial cross sections for electron excitation of atoms as a function of changes in spin and orbital angular momentum. This method provides a good signal-to-noise ratio in the energy region near threshold, and could be used to study long- or short-lived excited states of many atomic systems. Measurements for Na $3S\ensuremath{-}3P$, near-threshold excitation are reported here. The results are generally in good agreement with the close-coupling calculations of D. L. Moores and D. W. Norcross [J. Phys. B 5, 1482 (1972)] for the largest $\ensuremath{\Delta}{m}_{S}$ and $\ensuremath{\Delta}{m}_{L}$ components of the cross section, but not for the component with $|\ensuremath{\Delta}{m}_{S}|=1$ and $|\ensuremath{\Delta}{m}_{L}|=1$, indicating that the exchange interaction is larger than previously recognized.
Surveillance for Highly Pathogenic Avian Influenza Virus in Wild Birds during Outbreaks in Domestic Poultry, Minnesota, 2015 (2016)

In 2015, a major outbreak of highly pathogenic avian influenza virus (HPAIV) infection devastated poultry facilities in Minnesota, USA. To understand the potential role of wild birds, we tested 3,139 waterfowl fecal samples and 104 sick and dead birds during March 9-June 4, 2015. HPAIV was isolated from a Cooper's hawk but not from waterfowl fecal samples.
Imaging Techniques for Small Animal Models of Pulmonary Disease: MR Microscopy (2007)

In vivo magnetic resonance microscopy (MRM) of the small animal lung has become a valuable research tool, especially for preclinical studies. MRM offers a noninvasive and nondestructive tool for imaging small animals longitudinally and at high spatial resolution. We summarize some of the technical and biologic problems and solutions associated with imaging the small animal lung and describe several important pulmonary disease applications. A major advantage of MR is direct imaging of the gas spaces of the lung using breathable gases such as helium and xenon. When polarized, these gases become rich MR signal sources. In animals breathing hyperpolarized helium, the dynamics of gas distribution can be followed and airway constrictions and obstructions can be detected. Diffusion coefficients of helium can be calculated from diffusion-sensitive images, which can reveal micro-structural changes in the lungs associated with pathologies such as emphysema and fibrosis. Unlike helium, xenon in the lung is absorbed by blood and exhibits different frequencies in gas, tissue, or erythrocytes. Thus, with MR imaging, the movement of xenon gas can be tracked through pulmonary compartments to detect defects of gas transfer. MRM has become a valuable tool for studying morphologic and functional changes in small animal models of lung diseases.
Efficacy and safety of paliperidone palmitate in adult patients with acutely symptomatic schizophrenia: a randomized, double-blind, placebo-controlled, dose-response study (2010)

This 13-week, double-blind study evaluated the efficacy and safety of the atypical antipsychotic paliperidone palmitate (recently approved in the United States) versus placebo administered as monthly gluteal injections (after two initial doses given 1 week apart) in acutely symptomatic patients with schizophrenia. Patients (N=388) were randomly assigned (1 : 1 : 1 : 1) to paliperidone palmitate 50, 100, or 150 mg eq. or placebo. As the 150 mg eq. dose was administered to fewer patients (n=30) than planned, meaningful and definitive conclusions cannot be drawn from the results of this group. The change from baseline in Positive and Negative Syndrome Scale total score at endpoint showed improvement in both paliperidone palmitate 50 and 100 mg eq. groups but was significant only in the 100 mg eq. group (P=0.019). The paliperidone palmitate 50 (P=0.004) and 100 mg eq. (P<0.001) groups showed significant improvement in the Personal and Social Performance score from baseline to endpoint versus placebo. Common adverse events (in >or=2% of patients in any group) more frequent with paliperidone palmitate 50 or 100 mg eq. than placebo (>or=5% difference) were headache, vomiting, extremity pain, and injection site pain. Treatment with paliperidone palmitate (100 mg eq.) was efficacious and all doses tested were tolerable.
Mixed Viral Respiratory Infections (2014)

This chapter aims to summarize knowledge on mixed viral infections regarding epidemiological studies and to describe the potential impact of coinfection on disease outcomes. Mixed respiratory viral infections in adults have scarcely been studied, and therefore their clinical relevance remains unknown. The occurrence of viral codetections has received scarce attention, probably because the previously available detection methods lacked sensitivity. In children, according to several epidemiological studies, it may be assumed that the simultaneous presence of more than one viral pathogen would be associated with epidemiological and clinical features that differ from single infections, especially with respect to disease type and severity. The incidence of dual respiratory viral infections varies from 10% to 30% in hospitalized infants with bronchiolitis and may have an impact on the severity of the disease. The diagnosis of viral infections pursues several objectives. Most often, in a clinical setting, it is to prove the viral etiology of a suspected disease.
Fresnel Reflection Spectra at Multimode Optical Fiber Ends with Heterodyne Detection (2011)

The Fresnel reflection (FR) spectra at the ends of a step-index (SI-) multimode fiber (MMF) and a graded-index (GI-) MMF were investigated with heterodyne detection, and compared with that of a standard single-mode fiber (SMF). The FR spectra of the MMFs were found to spread broader than that of the SMF, and the FR spectrum of the SI-MMF was even broader than that of the GI-MMF. It was also demonstrated that the observation of the Brillouin gain spectrum in a polymer optical fiber (POF) is severely influenced by the FR spectrum. We believe that this information will provide a guideline for the design of robust Brillouin sensing systems using MMFs including POFs.
First observations of the rare decays B + → K + π + π − μ + μ − and B +→ ϕK + μ + μ − (2014)

First observations of the rare decays $B^+\\rightarrow K^+\\pi^+\\pi^-\\mu^+\\mu^-$ and $B^+\\rightarrow \\phi K^+\\mu^+\\mu^-$ are presented using data corresponding to an integrated luminosity of $3.0\\,{fb}^{-1}$, collected by the LHCb experiment at centre-of-mass energies of $7$ and $8\\mathrm{\\,TeV}$. The branching fractions of the decays are \\begin{eqnarray*} \\mathcal{B}(B^+\\rightarrow K^+\\pi^+\\pi^-\\mu^+\\mu^-) &amp;=&amp; (4.36\\,^{+0.29}_{-0.27}\\,\\mathrm{(stat)}\\pm 0.21\\,\\mathrm{(syst)}\\pm0.18\\,\\mathrm{(norm)})\\times10^{-7},\\\\ \\mathcal{B}(B^+\\rightarrow\\phi K^+\\mu^+\\mu^-) &amp;=&amp; (0.82 \\,^{+0.19}_{-0.17}\\,\\mathrm{(stat)}\\,^{+0.10}_{-0.04}\\,\\mathrm{(syst)}\\pm0.27\\,\\mathrm{(norm)}) \\times10^{-7},\\end{eqnarray*} where the uncertainties are statistical, systematic, and due to the uncertainty on the branching fractions of the normalisation modes. A measurement of the differential branching fraction in bins of the invariant mass squared of the dimuon system is also presented for the decay $B^+\\rightarrow K^+\\pi^+\\pi^-\\mu^{+}\\mu^{-}$.
Multimedia courseware sparks interest in the industry (1998)

The PowerLearn approach to power engineering education is under development by a core group of faculty and students at Iowa State University (ISU) and Virginia Tech (VT), under funding from the National Science Foundation (NSF) and the Electric Power Research Institute (EPRI). Four basic features characterize the approach. Courseware modularity provides that the material is organized by topic rather than by course. A Web site provides module storage and dissemination. Interactive visualization and simulation tools are heavily used in module construction. In addition, this project is integrated with efforts at both schools to develop new introductory undergraduate courses in electric power engineering. These courses serve well to illustrate the modular approach to course design.
Exogenous β2‐microglobulin is required for antigenic peptide binding to isolated class I major histocompatibility complex molecules (1991)

Binding of antigenic peptides to purified class I major histocompatibility complex (MHC) molecules, as measured by antigen-specific cytolytic T lymphocyte (CTL) degranulation, was found to occur in the presence of serum but not in its absence. The role of soluble beta 2-microglobulin (beta 2m), a normal component of serum, in class I-peptide complex formation was therefore examined. Sera depleted of beta 2m did not support effective peptide binding to class I, but binding was restored in the presence of low concentrations of purified human beta 2m. Sequential incubation of immobilized class I with human beta 2m first, followed by peptide, resulted in antigenic complex formation, while reversing the order of pulsing could not. Similar results were obtained in experiments examining H-2Db, Kb and Kd with appropriate peptides and CTL. These results demonstrate that mature class I proteins are not able to directly bind peptide, but that interaction with exogenous beta 2m results in a structure that will subsequently bind peptide. Binding of exogenous beta 2m appears to result in "empty" class I molecules, possibly by exchange for endogenous beta 2m, with a concomitant loss of endogenous peptide.
The Upstream Enhancer Is Necessary and Sufficient for the Expression of the Pre-T Cell Receptor α Gene in Immature T Lymphocytes (2001)

The expression of the pre-T cell receptor alpha (pTa) gene occurs exclusively in immature T lymphocytes and is regulated by poorly defined mechanisms. We have analyzed the role of the upstream enhancer in pTa expression using conventional and bacterial artificial chromosome (BAC) reporter transgenes. The deletion of the enhancer completely abolished the expression of pTa BAC reporter in transgenic mice. Conversely, the combination of pTa enhancer and promoter targeted transgenes specifically to immature thymocytes, recapitulating the expression pattern of pTa. The core enhancer is conserved between mice and humans and contains a critical binding site for the transcription factor c-Myb. We also show that pTa promoter contains a conserved tandem E box site activated by E protein, HEB. These data establish the enhancer as a critical element regulating pTa gene expression and identify additional targets for c-Myb and E proteins in T cell development.
Thermal behavior of a soldered Cu-Si interface (2004)

The thermal behavior of a reactively soldered interface between a Cu heat sink and a Si die is analyzed experimentally. Two aspects are addressed, thermal fatigue of these joints, and the survival of the circuitry on the die during joining. In the reactive soldering process a multilayered reactive NanoFoil/spl trade/ acts as a heat source for melting the solder during joining. The foils consists of hundreds of alternating nanoscale layers of Ni and Al, and supports controlled self-propagating reactions that can be initiated in air and at room temperature. The nanostructured reactive multilayered foils (NanoFoils) are designed to minimize thermal exposure of the components as well as residual stress. To study thermal fatigue of reactively soldered Cu-Si joints three populations of samples are studied, one fabricated using conventional soldering techniques, and two reactively soldered populations fabricated using different solder thicknesses. Both the conventionally and reactively soldered samples consist of a stack composed of two Cu blocks with a Si die soldered between them. The difference between these two types of samples is that for the conventionally soldered joints the heat source used for melting the solder is an oven, while for the reactively soldered joints a nanostructured reactive multilayered foil is used. We show that neither the conventionally soldered samples nor the reactively soldered populations exhibit significant degradation of thermal performance after 1000 cycles between 25 /spl deg/C and 125 /spl deg/C. In addition we show that a commercially available bare-die chip package can be successfully reactively bonded with no degradation in the performance of the chip, but does offer significant reduction in die operating temperature during normal operation.
Robot Finger Using Electro-Conjugate Fluid (2012)

Abstract An electro-conjugate fluid (ECF) is a kind of functional fluid, which produces a jet flow (ECF jet) when subjected to high DC voltage. It is known that a strong ECF jet is generated under a non-uniform electric field (e.g., a field with a pair of needle and ring electrodes (a needle–ring electrode pair)). This study introduces the ECF jet to develop a novel flexible robot finger. First, we propose a concept for a novel robot finger. The robot finger mainly consists of a bending actuator, an ECF tank and ECF jet generators, which could be a micro fluid pressure source of the robot finger. Second, we characterize each component of the robot finger (i.e., the bending actuator and the ECF jet generator). We investigate the influences of electrode parameters on ECF jet generator performance in order to design the finger prototype. Finally we clarify the characteristics of the robot finger. The length, the diameter and the mass of the robot finger are 34.2 mm, 12 mm and 3.8 g, respectively. The robot finger can generate a force of 0.28 N and bend approximately 70°.
Full Correlations across Broad NMR Spectra by Two‐Field Total Correlation Spectroscopy (2017)

Total correlation spectroscopy (TOCSY) is a key experiment to assign nuclear magnetic resonance (NMR) spectra of complex molecules. Carbon-13 TOCSY experiments are essential to assign signals of protein side chains. However, the performance of carbon-13 TOCSY deteriorates at high magnetic fields since the necessarily limited radiofrequency irradiation fails to cover the broad range of carbon-13 frequencies. Here, we introduce a new concept to overcome the limitations of TOCSY by using two-field NMR spectroscopy. In two-field TOCSY experiments, chemical shifts are labelled at high field but isotropic mixing is performed at a much lower magnetic field, where the frequency range of the spectrum is drastically reduced. We obtain complete correlations between all carbon-13 nuclei belonging to amino acids across the entire spectrum: aromatic, aliphatic and carboxylic. Two-field TOCSY should be a robust and general approach for the assignment of uniformly carbon-13 labelled molecules in high-field and ultra-high field NMR spectrometers beyond 1000 MHz.
Motivation and Context (2006)

This chapter contains sections titled: Evolution of Wireless Communication Systems Wireless Propagation Effects Parameters and Classification of Wireless Channels Providing, Enabling, and Collecting Diversity Chapter-By-Chapter Organization
Improved human islets’ viability and functionality with mesenchymal stem cells and arg-gly-asp tripeptides supplementation of alginate micro-encapsulated islets in vitro (2020)

The present findings show that bioprocessing a favorable composite environment inside the M-rich alginate capsule with both MSCs and RGD-G rich alginate improves human islets survival and functionality in vitro.
How the JSDL can exploit the parallelism? (2006)

The description of the jobs is a very important issue for the scheduling and management of grid jobs. Since there are a lot of different languages for describing grid jobs, the GGF have presented the Job Submission Description Language (JSDL) to standardize the job submission language. We believe that the JSDL is a good solution but it has some deficiencies regarding the parallelism issues. In this paper, we propose an extension of the JSDL to specify the parallelism details of grid jobs. This extension is proposed in general terms for supporting current multilevel parallel applications and incoming approaches in parallel programming models. We also discus the suitability of the multilevel parallel programming models for grids, in particular the MPI+OpenMP since our project, the eNANOS project, is based on this hybrid programming model.