gebhart/patrepeval huggingface dataset:
Antibiofilm surface functionalization of catheters by magnesium fluoride nanoparticles (2012)

The ability of bacteria to colonize catheters is a major cause of infection. In the current study, catheters were surface-modified with MgF(2) nanoparticles (NPs) using a sonochemical synthesis protocol described previously. The one-step synthesis and coating procedure yielded a homogenous MgF(2) NP layer on both the inside and outside of the catheter, as analyzed by high resolution scanning electron microscopy and energy dispersive spectroscopy. The coating thickness varied from approximately 750 nm to 1000 nm on the inner walls and from approximately 450 nm to approximately 580 nm for the outer wall. The coating consisted of spherical MgF(2) NPs with an average diameter of approximately 25 nm. These MgF(2) NP-modified catheters were investigated for their ability to restrict bacterial biofilm formation. Two bacterial strains most commonly associated with catheter infections, Escherichia coli and Staphylococcus aureus, were cultured in tryptic soy broth, artificial urine and human plasma on the modified catheters. The MgF(2) NP-coated catheters were able to significantly reduce bacterial colonization for a period of 1 week compared to the uncoated control. Finally, the potential cytotoxicity of MgF(2) NPs was also evaluated using human and mammalian cell lines and no significant reduction in the mitochondrial metabolism was observed. Taken together, our results indicate that the surface modification of catheters with MgF(2) NPs can be effective in preventing bacterial colonization and can provide catheters with long-lasting self-sterilizing properties.
Fluoro olefins. I. Synthesis of .beta.-substituted perfluoro olefins (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFluoro olefins. I. Synthesis of .beta.-substituted perfluoro olefinsFrank E. Herkes and Donald J. BurtonCite this: J. Org. Chem. 1967, 32, 5, 1311–1318Publication Date (Print):May 1, 1967Publication History Published online1 May 2002Published inissue 1 May 1967https://pubs.acs.org/doi/10.1021/jo01280a007https://doi.org/10.1021/jo01280a007research-articleACS PublicationsRequest reuse permissionsArticle Views1053Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Association between spinal stenosis and wild-type ATTR amyloidosis (2021)

Age-related cardiac amyloidosis results from deposits of wild-type tranthyretin amyloid (ATTRwt) in cardiac tissue. ATTR may play a role in carpal tunnel syndrome (CTS) and in spinal stenosis (SS), indicating or presaging systemic amyloidosis. We investigated consecutive patients undergoing surgery for SS for ATTR deposition in the resected ligamentum flavum (LF) and concomitant risk of cardiac amyloidosis. Each surgical specimen (LF) was stained with Congo red, and if positive, the amyloid deposits were typed by mass spectrometry. Patients with positive specimens underwent standard of care evaluation with fat pad aspirates, serum and urine protein electrophoresis with immunofixation, free light-chain assay, <i>TTR</i> gene sequencing and technetium 99 m-pyrophosphate-scintigraphy. In 2018-2019, 324 patients underwent surgery for SS and 43 patients (13%) had ATTR in the LF with wild-type <i>TTR</i> gene sequences. Two cases of ATTRwt cardiac amyloidosis were diagnosed and received treatment. In this large series, ATTRwt was identified in 13% of the patients undergoing laminectomy for SS. Patients with amyloid in the ligamentum flavum were older and had a higher prevalence of CTS, suggesting a systemic form of ATTR amyloidosis involving connective tissue. Further prospective study of patients with SS at risk for systemic amyloidosis is warranted.
On the Feasibility of Predicting Radiological Observations from Computational Imaging Features of Liver Lesions in CT Scans (2011)

We aim to predict radiological observations using computationally-derived imaging features extracted from CT images. Our dataset consists of 79 portal venous phase liver CT images containing lesions identified and annotated by a radiologist using a controlled vocabulary of 76 semantic terms. Computationally-derived features were extracted describing intensity, texture, shape, and edge sharpness. Linear discriminative analysis, logistic regression and LASSO were explored to predict the radiological observations using computational features. The approach was evaluated by leave one out cross-validation. Informative radiological observations such as lesion enhancement, hyper vascular attenuation, and homogeneous retention were discovered to be well-predicted by computational features. By exploiting relationships between computable and semantic features, this approach could lead to more accurate and efficient radiology reporting.
2D mixed finite element/analytical model of the mechanical coupling in ultrasonic array (2003)

The crosstalk between the elements of an acoustical array is a major cause of limitation of performance, when the pitch is around or below the wavelength. An accurate modelization of the mechanical part of the crosstalk can be obtained by finite element models. An original bidimensional mixed finite element/analytical analysis has been developed for infinite periodic arrays. The finite element method is used to analyze only one elementary transducer. Then, by expanding the electrical exitation of the array into harmonic exitations, the cross coupling is computed analytically for any combination of coupling layers including solid or fluid media. Both theoretical explanations and preliminary validations with previous analytical or numerical models are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Hybrid-integrated coherent receiver using silica-based planar lightwave circuit technology (2011)

A hybrid-integrated coherent receiver module has been achieved using flip-chip bonding technology, consisting of a silica-based 90°-hybrid planar lightwave circuit (PLC) platform, a spot-size converter integrated waveguide photodiode (SSC-WG-PD), and a dual-channel transimpedance amplifier (TIA). The receiver module shows error-free operation up to 40Gb/s and OSNR sensitivity of 11.5 dB for BER = 10−3 at 25 Gb/s.
Deep Morphological Anomaly Detection Based on Angular Margin Loss (2021)

Deep anomaly detection aims to identify “abnormal” data by utilizing a deep neural network trained on a normal training dataset. In general, industrial visual anomaly detection systems distinguish between normal and “abnormal” data through small morphological differences such as cracks and stains. Nevertheless, most existing algorithms emphasize capturing the semantic features of normal data rather than the morphological features. Therefore, they yield poor performance on real-world visual inspection, although they show their superiority in simulations with representative image classification datasets. To address this limitation, we propose a novel deep anomaly detection algorithm based on the salient morphological features of normal data. The main idea behind the proposed algorithm is to train a multiclass model to classify hundreds of morphological transformation cases applied to all the given data. To this end, the proposed algorithm utilizes a self-supervised learning strategy, making unsupervised learning straightforward. Additionally, to enhance the performance of the proposed algorithm, we replaced the cross-entropy-based loss function with the angular margin loss function. It is experimentally demonstrated that the proposed algorithm outperforms several recent anomaly detection methodologies in various datasets.
A Mild Exchange Reaction of Xanthates with Bromine (2002)

International audience
EUV resist simulation based on process parameters of pattern formation reaction (2014)

We simulated the process parameters of a pattern formation reaction that included during-the-exposure and post exposure bake (PEB) processes using an originally developed simulator. From the simulation results, the relationship between process parameters of pattern formation reaction and quencher concentration has been clarified. Moreover, we simulated the present target process parameters of extreme ultraviolet (EUV) resist for breaking the RLS trade-off. In this simulation, the process parameters were calculated from lithographic results (sensitivity, LWR, and CD) using real SEM images. This methodology was used to determine the process parameters required to break the RLS trade-off to obtain the required lithographic target of the EUV resist. We simulated the present lithography performance target using the process parameters of pattern formation reactions. These simulation results showed that a large reaction radius is necessary to break the RLS trade-off. Furthermore, we confirmed that increasing the PEB temperature leads to an improvement in the reaction radius. However, there is a discrepancy between the target radius and the controllable range of reaction radius that can be obtained by varying the PEB temperature.
<title>Noninvasive near-infrared hemoglobin spectroscopy for in vivo monitoring of tumor oxygenation and response to oxygen modifiers</title> (1997)

The shift in optical absorption of hemoglobin upon binding of oxygen provides a basis for near-infrared monitoring of hemoglobin oxygen saturation, which is an important indicator of tissue oxygenation. Tumor oxygenation has long been studied, because hypoxic cells exhibit resistance to ionizing radiation therapy. The ability to measure noninvasively the oxygenation status of tumors and their response to oxygen modifiers is important in research and clinical settings. We have implemented a steady-state diffuse reflectance method of optical spectroscopy in scattering systems based on the theory of Farrell et al. (Med. Phys., 1992). In scattering phantoms containing erythrocytes, the method recovers the hemoglobin absorption spectrum (650 - 820 nm) and accurately monitors hemoglobin oxygen saturation. We have implemented a probe that individually positions several detection fibers normal to the surface of subcutaneous rodent tumors. Near-infrared absorption spectra reconstructed from diffuse reflectance measurements indicate a hemoglobin oxygen saturation of approximately 50% in R3230AC rat mammary adenocarcinomas when the anesthetized animal breathes room air. Administration of carbogen (95% oxygen, 5% carbon dioxide) via a nose cone produces a rapid and readily detectable increase in the saturation to 75% with no increase in tumor blood volume. Several methods of determining hemoglobin oxygen saturation from absorption spectra obtained by diffuse reflectance spectroscopy are compared, including singular value decomposition, which provides the ability to reconstruct the non-hemoglobin absorbing background without a priori knowledge of its structure or absolute magnitude.
Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours (2015)

Currently available human tumour cell line panels consist of a small number of lines in each lineage that generally fail to retain the phenotype of the original patient tumour. Here we develop a cell culture medium that enables us to routinely establish cell lines from diverse subtypes of human ovarian cancers with >95% efficiency. Importantly, the 25 new ovarian tumour cell lines described here retain the genomic landscape, histopathology and molecular features of the original tumours. Furthermore, the molecular profile and drug response of these cell lines correlate with distinct groups of primary tumours with different outcomes. Thus, tumour cell lines derived using this methodology represent a significantly improved platform to study human tumour pathophysiology and response to therapy.
Arthroscopic revision rotator cuff repair of large and massive retears using an interpositional bridging dermal allograft (2022)

Interpositional bridging grafting for revision rotator cuff repair of large and massive retears leads to a significant improvement in functional outcome but is associated with a high retear rate.
Luciferins, Bioluminescent Substances (1968)

Abstract The bioluminescence of the American firefly Photinus is due to the reaction of 2‐(6‐hydroxybenzothiazol‐2‐yl)‐Δ 2 ‐1,3‐thiazoline‐4‐carboxylic acid (“firefly luciferin”) with the enzyme luciferase in the presence of ATP and magnesium ion. In the crustacean Cypridina, on the other hand, the bioluminescence is due to the reaction of a luciferase with 8‐(3‐guanidinopropyl)‐6‐indol‐3‐yl‐2‐(1‐methylpropyl)‐3,7‐dihydroimidazo[1,2‐a]‐pyrazin‐3‐one (“Cypridina luciferin”). The luciferin in Latia is 1,3,3‐trimethyl‐2‐(4‐formyloxy‐3‐methyl‐3‐butenyl)‐1‐cyclohexene and that in Renilla is a tryptamine derivative that has not yet been accurately identified; the luciferins of other luminescent organisms are not yet known. A review is given of the investigations which have been carried out on the above luciferins and the course of the luciferin‐luciferase reaction is examined. Numerous spectral data obtained during the examination of these compounds are included in the text.
Current status and future prospects of array-based comparative genomic hybridisation (2003)

The majority of human cancers as well as many developmental abnormalities harbour chromosomal imbalances, many of which result in the gain and/or loss of genomic material. Conventional comparative genomic hybridisation (CGH) has been used extensively to map DNA copy number changes to chromosomal positions. The introduction of microarray CGH provided a powerful tool to precisely detect and quantify genomic aberrations and map these directly onto the sequence of the human genome. In the past several years, a number of different approaches towards array-based CGH have been undertaken. This paper reviews these approaches and presents some of the recently-developed applications of this new technology in both research and clinical settings.
Top-coats for scalable nano-manufacturing with high-χ block copolymers in lithographic applications (2021)

Results for the self-assembly of lamellar silicon-containing high-χ block copolymers (BCP) with innovative neutral top-coat design are presented. We demonstrate that these materials and associated processes are compatible with a standard lithographic process, and oriented toward a potential high volume manufacturing. We show that this dedicated technology is able to guarantee the stability and planarity of the stack even at elevated self-assembly bake temperatures, and opens new opportunity in the fields of 3D BCPs stacks. Finally, we show interesting results for the etch-transfer of a lamellar BCP in silicon.
Performance assessment of a NaI(Tl) gamma counter for PET applications with methods for improved quantitative accuracy and greater standardization (2015)

Although NaI(Tl) gamma counters play an important role in many quantitative positron emission tomography (PET) protocols, their calibration for positron-emitting samples has not been standardized across imaging sites. In this study, we characterized the operational range of a gamma counter specifically for positron-emitting radionuclides, and we assessed the role of traceable 68Ge/68Ga sources for standardizing system calibration. A NaI(Tl) gamma counter was characterized with respect to count rate performance, adequacy of detector shielding, system stability, and sample volume effects using positron-emitting radionuclides (409- to 613-keV energy window). System efficiency was measured using 18F and compared with corresponding data obtained using a long-lived 68Ge/68Ga source that was implicitly traceable to a national standard. One percent count loss was measured at 450 × 103 counts per minute. Penetration of the detector shielding by 511-keV photons gave rise to a negligible background count rate. System stability tests showed a coefficient of variation of 0.13% over 100 days. For a sample volume of 4 mL, the efficiencies relative to those at 0.1 mL were 0.96, 0.94, 0.91, 0.78, and 0.72 for 11C, 18F, 125I, 99mTc, and 51Cr, respectively. The efficiency of a traceable 68Ge/68Ga source was 30.1% ± 0.07% and was found to be in close agreement with the efficiency for 18F after consideration of the different positron fractions. Long-lived 68Ge/68Ga reference sources, implicitly traceable to a national metrology institute, can aid standardization of gamma counter calibration for 18F. A characteristic feature of positron emitters meant that accurate calibration could be maintained over a wide range of sample volumes by using a narrow energy window centered on the 511-keV peak.
Spur-Free Dynamic Range Measurements of a Traveling Wave Mach-Zehnder Carrier Depletion Silicon Modulator (2013)

Thesis (Master's)--University of Washington, 2012
Data Hiding Capacity and Embedding Techniques for Printed Text Documents (2006)

In previous publications we have demonstrated the use of laser intensity modulation to embed information in halftone and text documents. In those experiments we were able to embed and correctly decode 33 bits in a 12 point page of printed text. In this paper we will present our current work on developing a channel model for a text document. This model will allow us to define capacity bounds for the channel and to better understand the modulation and detection techniques that can be used to reach that capacity.
Separation Using Encapsulated Metal Hydride (2001)

Metal hydride particles were encapsulated in a porous silica matrix. The encapsulation process successfully converted the small metal hydride particles into large granules suitable for packing gas separation columns. The granules absorbed hydrogen readily and withstood many hydrogen absorption cycles without producing fines. The porosity of the silica matrix was optimized so that the pores were large enough to allow hydrogen to easily move within the matrix and react with the metal hydride particles, but small enough to act as a filter to prevent passage of larger molecules including harmful impurities. An experimental apparatus has been installed to test the granules for hydrogen separation from other gases using a thermal absorption process.
A &#x2211;&#x0394; based DC-DC converter with supply noise suppression (2007)

An architecture that reduces the effects of supply noise on the regulated output of a DC-DC converter has been proposed. The structure consists of a Sigma-Delta modulator which drives the half bridge switches directly. The output of the quantizer is taken as the feedback for the Sigma-Delta as usual, but this feedback signal goes to a one-bit digital-to-analog converter that uses the noisy voltage supply as a reference to suppress the supply noise at the output. The proposed structure, designed and simulated using a 2.5V TSMC 0.25u process, shows supply ripple suppression.
Dicyanocarbodiimide and Trinitreno‐s‐triazine Generated by Consecutive Photolysis of Triazido‐s‐triazine in a Low‐Temperature Nitrogen Matrix (2003)

Carbon nitride molecules: Photolysis (λ=266 nm) of triazido-s-triazine (C3N12, 1) in a nitrogen matrix at 20 K yielded a succession of reactive species (see scheme), including, in order, an apparent trinitrene, NCN, and a novel C3N4 isomer, dicyanocarbodiimide NCNCNCN. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2003/z51879_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
The kingdoms of Carl Woese (2013)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Development of Innovative Application Films for Silicon Solar Cells Using a Copper–Phosphorus Alloy by an Atmospheric Sintering Process (2013)

In this paper we aim to develop copper (Cu)-based backside soldering tabs/pads for crystalline silicon (Si) solar cells using atmospheric sintering. In our previous study, we found that a Cu network can be formed in an application film (AF) by self-deoxidization when the AF consisting of copper-phosphorus (Cu-P) alloy paste is sintered in an atmospheric environment, and the Cu AF showed low electrical resistivity that satisfied the criteria for backside soldering tabs/pads. In this study, Si solar cells using Cu AF for front-side contacts were evaluated to confirm that Cu AF is applicable to Si solar cells in principle. The Cu-P alloy paste using Cu-7 mass%P particles was printed on an Si wafer and, finally, sintered at 640 °C in atmosphere. The resulting AF showed low electrical resistivity of 2.96 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-5</sup> Ωcm. The solar cell using the Cu AF and conductive glass layer had conversion efficiency (η) of 6.6%. We demonstrated the need for a barrier layer to prevent the formation of Cu 3Si compound on the Si wafer surface when applying it to Cu AF on the solar cells. Our results may improve the potential for the widespread use of an atmospheric sintered Cu AF as backside soldering tabs/pads for Si solar cells.
The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells (2012)

CLEC9A is a recently discovered C-type lectin receptor involved in sensing necrotic cells. In humans, this receptor is selectively expressed by BDCA3(+) myeloid dendritic cells (mDCs), which have been proposed to be the main human cross-presenting mDCs and may represent the human homologue of murine CD8(+) DCs. In mice, it was demonstrated that antigens delivered with antibodies to CLEC9A are presented by CD8(+) DCs to both CD4(+) and CD8(+) T cells and induce antitumor immunity in a melanoma model. Here we assessed the ability of CLEC9A to mediate antigen presentation by human BDCA3(+) mDCs, which represent < 0.05% of peripheral blood leukocytes. We demonstrate that CLEC9A is only expressed on immature BDCA3(+) mDCs and that cell surface expression is lost after TLR-mediated maturation. CLEC9A triggering via antibody binding rapidly induces receptor internalization but does not affect TLR-induced cytokine production or expression of costimulatory molecules. More importantly, antigens delivered via CLEC9A antibodies to BDCA3(+) mDCs are presented by both MHC class I (cross-presentation) and MHC class II to antigen-specific T cells. We conclude that CLEC9A is a promising target for in vivo antigen delivery in humans to increase the efficiency of vaccines against infectious or malignant diseases.
Supplementary Data S3a and S3b from Optimizing Precision Medicine for Breast Cancer Brain Metastases with Functional Drug Response Assessment (2023)

&lt;p&gt;Genomic comparison across the different metastatic sites compared to the matched primary. A. Genomic alterations across metastatic sites compared to matched primary B. Copy number variations across metastatic sites compared to matched primary&lt;/p&gt;