gebhart/patrepeval huggingface dataset:
3D–Printed Tunable Helical Resonators for Miniaturized VHF Filters (2019)

In this paper, a 3D-printed miniaturized tunable helical resonator for VHF applications is presented for the first time. The cavity and the helical resonator are 3D-printed while the cavity top cover is a printed circuit board (PCB). The frequency tuning is made possible by using varactor diodes. Direct tapping is used to couple externally into the 3D-printed helical resonator. Coplanar waveguides, realized on the top PCB layer, are utilized to form transitions from the ports to the tap-lines. The proposed 3D-printed helical resonator achieved a measured unloaded quality (Q) factor of 168-239 over a tuned center frequency of 170-240 MHz.
Fibroblast stimulation in schistosomiasis. V. Egg granuloma macrophages spontaneously secrete a fibroblast-stimulating factor. (1984)

Isolated intact egg granulomas from the liver of Schistosoma mansoni-infected mice have been previously shown to elaborate factors in vitro that can stimulate fibroblasts for biological functions that are of potential importance in the pathogenesis of hepatic fibrosis in schistosomiasis. We report here that cell cultures obtained from monodispersed granuloma cell suspensions, and specifically enriched for macrophages (95% to 100%) spontaneously elaborated fibroblast proliferation-stimulating activity in vitro. These cells possessed functional and phenotyptic characteristics of activated macrophages. In contrast, control peritoneal macrophages from uninfected mice lacked such phenotypic characteristics, and did not spontaneously elaborate fibrogenic activity in vitro. The granuloma macrophage activity was present, pre-formed within the isolated cells, and was continuously elaborated during 72 hr of incubation. By gel infiltration chromatography (Sephacryl S-200 sf), fibroblast-stimulating activity was identified in two pooled fractions, one with estimated molecular radius (Mr) of 46 kd to 57 kd and the other with Mr of 10 kd to 16 kd. Preparative isoelectric focusing in granular gel of crude macrophage culture supernatants identified peak activity in fractions with pI approximately 5. Two different serine esterase inhibitors had no effect on the ability of crude granuloma macrophage supernatants to stimulate fibroblast proliferation. Whereas crude and chromatographed fractions of granuloma macrophage supernatant were active for fibroblasts, they had minimal or no interleukin 1 (IL 1) activity when tested in a thymocyte proliferation assay. In contrast, resident peritoneal macrophages from the same infected mice spontaneously secreted substantial IL 1 and fibroblast-stimulating activity in vitro. We conclude that egg granuloma macrophages are activated in vivo to secrete fibrogenic molecules functionally distinct from IL 1, which might contribute to the pathogenesis of hepatic fibrosis in schistosomiasis.
A laboratory model of the Harris magnetic field (2004)

Summary form only given. An often-used approximation to the magnetotail field and the reconnection layer magnetic fields is the modified Harris field which consists of a neutral sheet magnetic field profile B/sub x/(z)x along with a superimposed normal field B/sub z/z. We have designed a configuration of current-carrying conductors and Helmholtz coil fields aimed at producing the topological characteristics of this field. As a criterion of validity of this simulation we appeal to the energy resonance phenomenon which is an essential feature of nonlinear particle dynamics in magnetotail-like magnetic fields. The phenomenon is characterized by periodic peaks and valleys occurring in scattered particle distribution functions when plotted versus energy. The "neutral sheet" of the simulated field is not actually plasma current which self-consistently is responsible for the magnetic field, but rather the field is produced by planar arrays of current carrying wires. For this reason certain self-consistency requirements on particle orbits in such fields do not arise. Particle injection into the field region, which is formed by 4 conducting wire grids and an external constant field, is accomplished with a programmable electron gun with energies in the range 200 eV to 10 keV. The basic physics of the resonance phenomenon, which occurs if the average radius of curvature of the field and the Larmor radius of injected particles are comparable, is scalable from the experiment to the magnetotail environment and has no dimensional dependence. We have re-examined earlier particle orbit data, restricting the analysis to particles whose gyroradii are consistent with this requirement. We present details of the creation of the field in the laboratory which includes realistic design considerations related to the method of producing the field. In addition the results of test-particle simulations showing the effect of the finite thickness of conducting wires are shown. Finally we present data from experiments performed in the NRL Space Physics Simulation Chamber including the field construction and detected particle orbits.
Strength of steel fiber reinforced concrete beams in pure torsion (2018)

This paper presents a simple yet accurate technique for determining the strength of steel fiber reinforced concrete beams loaded in pure torsion. The results of the model are compared with 21 beams found in the literature as well as two new beams tested by the authors and reported herein. The model considers the beneficial effect of the fibers in resisting tension after the concrete matrix has cracked, and it is implemented into the widely accepted space truss analogy for reinforced concrete members subjected to pure torsion. The proposed model provides good correlations to the collected test data with a test to predicted ratio of 1.10 and COV of 0.19. A simplified method of the aforementioned model, suitable for design, is also presented and is shown to provide good predictions to the test data.
Data from Routine Plasma-Based Genotyping to Comprehensively Detect Germline, Somatic, and Reversion <i>BRCA</i> Mutations among Patients with Advanced Solid Tumors (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;PARP inhibitors (PARPi) are efficacious in multiple cancers harboring germline (and possibly somatic) &lt;i&gt;BRCA1/2&lt;/i&gt; mutations. Acquired reversions can restore &lt;i&gt;BRCA1/2&lt;/i&gt; function, causing resistance to PARPi and/or platinum-based chemotherapy. The optimal method of identifying patients with germline, somatic, and/or reversion mutations in &lt;i&gt;BRCA1/2&lt;/i&gt; has not been established. Next-generation sequencing (NGS) of cell-free DNA (cfDNA) provides a platform to identify these three types of &lt;i&gt;BRCA1/2&lt;/i&gt; mutations.&lt;/p&gt;Experimental Design:&lt;p&gt;Patients with advanced breast, ovarian, prostate, or pancreatic cancer were tested using a clinically validated 73-gene cfDNA assay that evaluates single-nucleotide variants and insertion–deletion mutations (indels) in &lt;i&gt;BRCA1/2&lt;/i&gt;, and distinguishes somatic/reversion from germline mutations with high accuracy.&lt;/p&gt;Results:&lt;p&gt;Among 828 patients, one or more deleterious &lt;i&gt;BRCA1/2&lt;/i&gt; mutations were detected in 60 (7.2%) patients, including germline (&lt;i&gt;n&lt;/i&gt; = 42) and somatic (&lt;i&gt;n&lt;/i&gt; = 18) mutations. Common coexisting mutations included &lt;i&gt;TP53&lt;/i&gt; (61.6%), &lt;i&gt;MYC&lt;/i&gt; (30%), &lt;i&gt;PIK3CA&lt;/i&gt; (26.6%), &lt;i&gt;BRAF&lt;/i&gt; (15%), and &lt;i&gt;ESR1&lt;/i&gt; (11.5%). Polyclonal reversion mutations (median, 5) were detected in 9 of 42 (21.4%) germline &lt;i&gt;BRCA1/2-&lt;/i&gt;mutant patients, the majority (77.7%) of whom had prior PARPi exposure (median duration, 10 months). Serial cfDNA demonstrated emergence of reversion &lt;i&gt;BRCA&lt;/i&gt; mutations under therapeutic pressure from initial PARPi exposure, which contributed to subsequent resistance to PARPi and platinum therapy.&lt;/p&gt;Conclusions:&lt;p&gt;cfDNA NGS identified high rates of therapeutically relevant mutations without foreknowledge of germline or tissue-based testing results, including deleterious somatic &lt;i&gt;BRCA1/2&lt;/i&gt; mutations missed by germline testing and reversion mutations that can have important treatment implications. Further research is needed to confirm clinical utility of these findings to guide precision medicine approaches for patients with advanced malignancies.&lt;/p&gt;&lt;/div&gt;
Topographical Guidance of PSC-Derived Cortical Neurons (2018)

Background and Aims . Human pluripotent stem cell- (PSC-) derived neurons are increasingly used in the study of neurodevelopmental and neurodegenerative diseases. Electrophysiological activity is a crucial and defining function of these neurons. Patch clamping and the more recently developed multielectrode arrays are used to evaluate this complex function. In this study, we assess the effect of topography on PSC-derived neurons as a baseline for the development of next-generation silicon oxide substrates (in direct relation to MEA fabrication) that integrate topography as a means to guide network formation and stimulate differentiation. Methods . Human PSC was differentiated towards cortical neurons and seeded on a silicon micropatterned substrate to screen for topographic guidance and improved neurite outgrowth. We next developed customized micropillar and microgroove substrates to further assess the effect of topography on human cortical neurons. Immunocytochemistry and morphological analyses were used to track neuron differentiation and guidance. Results . Microgroove and micropillar substrates appeared to support the differentiation of human stem cell-derived cortical neurons, promoted neurite outgrowth, and facilitated contact guidance. In contrast to flat surfaces, topography also appeared to limit the number of NESTIN positive neuronal progenitor cells present in the culture. Conclusion . We describe the topographical preferences of human PSC-derived cortical neurons, on neurite outgrowth and guidance. Embedding topography in silicon substrates may be an effective approach to direct and improve neuronal network formation. We propose to integrate topography in multielectrode arrays as a practical method to shape the neuro-electronic interface.
Supplemental Figure 2 from Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer (2023)

&lt;p&gt;Supplemental Figure 2&lt;/p&gt;
Multilevel Security for Knowledge-Based Systems (1987)

The paper presents results of an initial investigation of multilevel security for knowledge-based systems. Knowledge-based systems are computer programs that give advice using techniques developed in artificial intelligence research. Although many apparently multilevel knowledge-based systems are now being developed, security requirements have not yet been articulated for them. We adopt the production system model as a generalization of knowledge-based systems. We apply noninterference concepts of multilevel security to the production model, and from this we suggest an approach for achieving multilevel secure production systems. Our approach puts control structures at system low, assigns a single classification to entries in the knowledge base, and provide different views both of the database and of the rule base depending upon the clearance of the user. We conclude that it will be possible to achieve multilevel security for many knowledge-based systems. We present a research agenda for further study,
A UWB through-wall radar using beam scanning array antenna (2011)

A UWB through-wall radar using novel beam scanning array antenna previously proposed by the authors is described. This antenna scanning system has two new technologies. First, each antenna element is equipped with an impulse generator. Second, the time control between the antenna elements is realized by using tapped delay lines and by transmitting trigger signals. Based upon above technology, experimental UWB through-wall radar having beam scanning capability is designed and constructed. The fabricated radar has compact size and light weight and is easy to use. The measurement results show excellent space resolution as a through-wall radar.
Application of Lumley’s Drag Reduction Model to Two-Phase Gas-Particle Flow in a Pipe (1991)

A “two-fluid model” has been incorporated with Lumley’s drag reduction model to analyze the mechanism of momentum transfer in the turbulent dilute gas-particle flow in a vertical pipe. The change of the effective viscous sublayer thickness by the presence of particles is modeled by Lumley’s theoretical model. The numerical computations of the friction factor and the pressure drop in a fully developed pipe flow are in good agreement with the corresponding experimental data for an average particle size of 15 μm. It is proved that Lumley’s model is successful in predicting the correct reduction behavior of the drag in the gas-particle flows. It has been confirmed that the effective viscous sublayer thickness for two-phase gas-particle flow is dependent on the particle relaxation time, Kolmogoroff time scale and the solids-gas loading ratio.
Zen3: The AMD 2nd-Generation 7nm x86-64 Microprocessor Core (2022)

“Zen 3” is the first major microarchitectural redesign in the AMD Zen family of microprocessors. Given the same 7nm process technology as the prior-generation “Zen 2” core [1], as well as the same platform infrastructure, the primary “Zen 3” design goals were to provide: 1) a significant instruction-per-cycle (IPC) uplift, 2) a substantial frequency uplift, and 3) continued improvement in power efficiency. The core complex unit (CCX) consists of 8 “Zen 3” cores, each with a 0.5MB private L2 cache, and a 32MB shared L3 cache. Increasing this from 4 cores and 16MB L3 in the prior generation provides additional performance uplift, in addition to the IPC and frequency improvements. The “Zen 3” CCX shown in Fig. 2.7.1 contains 4.08B transistors in 68mm2, and is used across a broad array of client, server, and embedded market segments.
Bulk micromachined angular rate sensor based on the 'butterfly'-gyro structure (2002)

The principle of the butterfly-gyro was first demonstrated with a large anisotropically etched structure in bulk silicon. Now the same principle has been used to develop a much smaller structure (9.6 mm/sup 2/). The new sensor chip is ICP-etched in bulk silicon and anodically bonded to form a triple stack (glass/Si/glass) structure. Together with an ASIC the sensor typically shows a noise level of 0.3 /sup o///sub s/ over 50 Hz bandwidth and a zero-rate offset (ZRO) less than 50 /sup o///sub s/.
Integrated bio-photonics to revolutionize health care enabled through PIX4life and PIXAPP (2018)

Photonics has become critical to life sciences. However, the field is far from benefiting fully from photonics' capabilities. Today, bulky and expensive optical systems dominate biomedical photonics, even though robust optical functionality can be realized cost-effectively on single photonic integrated circuits (PICs). Such chips are commercially available mostly for telecom applications, and at infrared wavelengths. Although proof-of-concept demonstrations for PICs in life sciences, using visible wavelengths are abundant, the gating factor for wider adoption is limited in resource capacity. Two European pilot lines, PIX4life and PIXAPP, were established to facilitate European R and D in biophotonics, by helping European companies and universities bridge the gap between research and industrial development. Through creation of an open-access model, PIX4life aims to lower barriers to entry for prototyping and validating biophotonics concepts for larger scale production. In addition, PIXAPP enables the assembly and packaging of photonic integrated circuits.
Towards Decision Support and Goal Achievement (2015)

Every day, people take actions, trying to achieve their personal, high-order goals. People decide what actions to take based on their personal experience, knowledge and gut instinct. While this leads to positive outcomes for some people, many others do not have the necessary experience, knowledge and instinct to make good decisions. What if, rather than making decisions based solely on their own personal experience, people could take advantage of the reported experiences of hundreds of millions of other people?
Extracellular Biosynthesis of Bimetallic Au–Ag Alloy Nanoparticles (2005)

The exposure of a mixture of 1 mM HAuCl4 and 1 mM AgNO3 solutions to different amounts of fungal biomass (Fusarium oxysporum) results in the formation of highly stable Au–Ag alloy nanoparticles with dimensions of 8–14 nm depending on metal molar fraction (see image). The amount of cofactor NADH released by the F. oxysporum fungus plays an important role in controlling the composition of the alloy nanoparticles. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2421/2005/z400053_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Detection Limits of a Laboratory Pulsed Gamma Neutron Activation Analysis System for the Nondestructive Assay of Mercury, Cadmium, and Lead (1998)

Detection of Hg, Cd, and Pb within concrete matrices located in 8-gal drums was successfully demonstrated using a pulsed gamma neutron activation analysis system. Real-time assays of 600 s led to the detection of these metals at concentration levels ranging, in parts per million (ppm) by weight, from 487 to 19 820 for Hg, 485 to 8181 for Cd, and 9927 to 19 950 for Pb. The measurements of Hg and Cd relied on the observation of thermal neutron-induced prompt gamma rays, whereas the Pb measurements relied on the observation of decay gamma rays from 207mPb, a product of fast neutron-induced reactions in Pb. The projected lower limits of detection of the current system for a 600-s run are 15, 170, and 8600 ppm for Cd, Hg, and Pb, respectively. Up to a one-order magnitude of improvement in sensitivity is anticipated through the enhancement of the system’s detector and neutron source. The results obtained confirm the potential of prompt and decay gamma neutron activation analysis as an effective method for the nondestructive analysis of hazardous metals in mixed-waste drums.
Focal atrial tachycardia is predominantly localized re-entry in the context of persistent AF ablation (2008)

info:eu-repo/semantics/published
Formation of a long-lived electron-transfer state of a naphthalene–quinolinium ion dyad and the π-dimer radical cation (2011)

An electron donor-quinolinium ion dyad, 2-phenyl-4-(1-naphthyl)quinolinium ion (QuPh+-NA), has been synthesized based on a rational design. The X-ray crystal structure of QuPh+-NA indicates that the dihedral angle between the NA and QuPh+ moieties of QuPh+-NA is nearly perpendicular. The one-electron reduction potential (E(red)) was observed as a well-defined reversible wave at -0.90 V versus SCE. The one-electron reduced species (QuPh*-NA) was detected by ESR. The electron self-exchange rate constant (k(ex)) between QuPh+-NA and QuPh*-NA has been determined from the ESR linewidth alternation. The reorganization energy (lambda) of the electron self-exchange was determined to be 0.42 eV from the k(ex) value. Femtosecond laser irradiation of QuPh+-NA at 355 nm results in formation of the ET state (QuPh*-NA*+) within 0.5 ps via photoinduced ET from NA to the singlet-excited state of QuPh+. The transient absorption bands at 420 nm and 700 nm are assigned to the QuPh and NA*+ moieties, respectively. The nanosecond laser excitation of QuPh+-NA affords the broad absorption band at 1000 nm and is due to the pi-dimer radical cation formed between QuPh*-NA*+ and QuPh+-NA. The intramolecular back electron-transfer process was too slow to compete with the intermolecular back electron-transfer reaction judging from the decay time profile of QuPh*-NA*+, which obeyed second-order kinetics.
Efficacy of Acetamiprid Granule against Cotton Aphid on Cucumber Plants by Various Application Methods (2001)

アセタミプリドの非徐放性粒剤についてキュウリ寄生ワタアブラムシに対する植穴処理における処理方法の違いによる効力を比較したところ, 粒剤を植穴に均一に処理しても, また植穴の中心にのみ処理してもほぼ同等の効力を得た. 土壌表面処理では株元から粒剤処理位置までの距離が5, 10, 20cm範囲では, その距離が短いほど高い効力があった. この傾向は徐放性粒剤でも同様であり, 対照薬剤との比較では, アセフェートと同様であった. 一方, ベンフラカーブでは処理20日以降では処理位置5cmに比べ20cmのほうが優り, 前述の2薬剤とは傾向を異にした. これは, 薬剤の水溶性の違いによる土壌中での移動の差によるものと考えられた. 灌水量と効力の関係は, 植穴処理 (植え穴に粒剤を均一に処理) および土壌表面処理 (株元から10cmの位置に円状に処理) について多灌水区, 少灌水区を設けて効力を検討したところ, 植穴処理では少灌水区>多灌水区, 表面処理では多灌水区>少灌水区で, 総じて植穴処理>土壌表面処理であった. 植穴処理の多灌水区のアブラムシに対する効力が少灌水区のそれに劣ったのは, 粒剤から溶出した原体成分が根から吸収できる範囲外へも移動してしまったためと考えられた. さらに, 徐放性粒剤を用いて, 灌水量, 土壌の違いによる効力の温室内ポット試験結果から, 土壌の違いにより灌水量と効力の関係が異なることが判明した.
Towards automatic association of relevant unstructured content with structured query results (2005)

Faced with growing knowledge management needs, enterprises are increasingly realizing the importance of seamlessly integrating critical business information distributed across both structured and unstructured data sources. In existing information integration solutions, the application needs to formulate the SQL logic to retrieve the needed structured data on one hand, and identify a set of keywords to retrieve the related unstructured data on the other. This paper proposes a novel approach wherein the application specifies its information needs using only a SQL query on the structured data, and this query is automatically ``translated'' into a set of keywords that can be used to retrieve relevant unstructured data. We describe the techniques used for obtaining these keywords from (i) the query result, and (ii) additional related information in the underlying database. We further show that these techniques achieve high accuracy with very reasonable overheads.
Preparation of oriented Bi-Ca-Sr-Cu-O thin films using pulsed laser deposition (1988)

Oriented c-axis thin films of Bi-Ca-Sr-Cu-O on [100] SrTiO3 substrates have been fabricated using the pulsed excimer laser evaporation technique. Deposition at room temperature in 1 mTorr oxygen followed by an 875 °C anneal in oxygen yields superconducting films with zero resistance at 80 K and a resistivity drop near 110 K, hinting at the presence of another superconducting phase. Transmission electron microscopy shows that the films are epitaxial with the substrate, with an abrupt and planar interface boundary. The observed crystal structure is consistent with diffraction results on bulk materials.
A novel supra-annular plane to predict TAVI prosthesis anchoring in raphe-type bicuspid aortic valve disease: the LIRA plane (2020)

TAVI in bicuspid aortic valve.
Bilateral Renal Calculi: Assessment of Staged v Synchronous Percutaneous Nephrolithotomy (2004)

These results demonstrate similar stone-free rates, blood loss per operation, and transfusion rates for simultaneous and staged bilateral PCNL. The reduced total operative time, hospital stay, and total blood loss, along with the requirement for only one anesthesia, makes synchronous bilateral PCNL an attractive option for select individuals. However, in patients with larger, less easily accessible stones, excessive bleeding may be encountered more frequently on the first side, thereby delaying management of the second side to a later date. Synchronous bilateral PCNL should be considered in patients in whom the first stage of stone removal is accomplished quickly and safely.
Improved upper bound for the redundancy of fix-free codes (2003)

A variable-length code is a fix-free code if no codeword is a prefix or a suffix of any other codeword. In fix-free code any finite sequence of codewords can be decoded in both directions, which can improve robustness to channel noise and speed up the decoding process. In this paper we prove a new sufficient condition for existence of fix-free codes and improve upper bound on the redundancy of optimal fix-free codes.