gebhart/patrepeval huggingface dataset:
Energy-Efficient Classification at the Wireless Edge with Reliability Guarantees (2022)

Learning at the edge is a challenging task from several perspectives, since data must be collected by end devices (e.g. sensors), possibly pre-processed (e.g. data compression), and finally processed remotely to output the result of training and/or inference phases. This involves heterogeneous resources, such as radio, computing and learning related parameters. In this context, we propose an algorithm that dynamically selects data encoding scheme, local computing resources, uplink radio parameters, and remote computing resources, to perform a classification task with the minimum average end devices' energy consumption, under E2E delay and inference reliability constraints. Our method does not assume any prior knowledge of the statistics of time varying context parameters, while it only requires the solution of low complexity per-slot deterministic optimization problems, based on instantaneous observations of these parameters and that of properly defined state variables. Numerical results on convolutional neural network based image classification illustrate the effectiveness of our method in striking the best trade-off between energy, delay and inference reliability.
Rapid Identification of Aspergillus terreus from Bronchoalveolar Lavage Fluid by PCR and Electrospray Ionization with Mass Spectrometry (2012)

We describe the application of PCR and electrospray-ionization with mass spectrometry (PCR/ESI-MS) to culture-negative bronchoalveolar lavage (BAL) fluid in order to identify septate hyphae noted by Gomori methenamine silver (GMS) staining of the fluid that was obtained from an immunocompromised woman with neutropenia following induction chemotherapy for treatment of acute myelogenous leukemia (AML). The patient was treated with empirical antifungal therapy, including intrathecal amphotericin B, while results of fungal cultures were pending. Ultimately, Aspergillus terreus, an amphotericin-resistant mold, was cultured from bilateral brain abscesses. PCR/ESI-MS correctly identified the mold.
A facile one-pot synthesis of homopropargylic alcohols from terminal acetylenes (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleA facile one-pot synthesis of homopropargylic alcohols from terminal acetylenesMark R. Burns and James K. CowardCite this: J. Org. Chem. 1993, 58, 2, 528–532Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/jo00054a047https://doi.org/10.1021/jo00054a047research-articleACS PublicationsRequest reuse permissionsArticle Views178Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
The Cyclin-dependent Kinase Inhibitor CYC202 (R-Roscovitine) Inhibits Retinoblastoma Protein Phosphorylation, Causes Loss of Cyclin D1, and Activates the Mitogen-activated Protein Kinase Pathway (2004)

Deregulation of the cell cycle commonly occurs during tumorigenesis, resulting in unrestricted cell proliferation and independence from mitogens. Cyclin-dependent kinase inhibitors have the potential to induce cell cycle arrest and apoptosis in cancer cells. CYC202 (R-roscovitine) is a potent inhibitor of CDK2/cyclin E that is undergoing clinical trials. Drugs selected to act on a particular molecular target may exert additional or alternative effects in intact cells. We therefore studied the molecular pharmacology of CYC202 in human colon cancer cells. Treatment of HT29 and KM12 colon carcinoma cell lines with CYC202 decreased both retinoblastoma protein phosphorylation and total retinoblastoma protein. In addition, an increase in the phosphorylation of extracellular signal-regulated kinases 1/2 was observed. As a result, downstream activation of the mitogen-activated protein kinase pathway occurred, as demonstrated by an increase in ELK-1 phosphorylation and in c-FOS expression. Use of mitogen-activated protein kinase kinases 1/2 inhibitors showed that the CYC202-induced extracellular signal-regulated kinases 1/2 phosphorylation was mitogen-activated protein kinase kinases 1/2 dependent but did not contribute to the cell cycle effects of the drug, which included a reduction of cells in G(1), inhibition of bromodeoxyuridine incorporation during S-phase, and a moderate increase in G(2)-M phase. Despite activation of the mitogen-activated protein kinase pathway, cyclin D1 protein levels were decreased by CYC202, an effect that occurred simultaneously with loss of retinoblastoma protein phosphorylation and inhibition of cell cycle progression. The reduced expression of cyclin D1 protein was independent of the p38(SAPK) and phosphatidylinositol 3-kinase pathways, which are known regulators of cyclin D1 protein. Interestingly, CYC202 caused a clear reduction in cyclins D1, A, and B1 mRNA, whereas c-FOS mRNA increased by 2-fold. This was accompanied by a loss of RNA polymerase II phosphorylation and total RNA polymerase II protein, suggesting that CYC202 was inhibiting transcription, possibly via inhibition of CDK7 and CDK9 complexes. It can be concluded that although CYC202 can act as a CDK2 inhibitor, it also has the potential to inhibit CDK4 and CDK1 activities in cancer cells through the down-regulation of the corresponding cyclin partners. This provides a possible mechanism by which CYC202 can cause a reduction in retinoblastoma protein phosphorylation at multiple sites and cell cycle arrest in G(1), S, and G(2)-M phases. In addition to providing useful insights into the molecular pharmacology of CYC202 in human cancer cells, the results also suggest potential pharmacodynamic end points for use in clinical trials with the drug.
Induced polarization and pore radius — A discussion (2016)

ABSTRACT Permeability estimation from induced polarization (IP) measurements is based on a fundamental premise that the characteristic relaxation time τ is related to the effective hydraulic radius reff controlling fluid flow. The approach requires a reliable estimate of the diffusion coefficient of the ions in the electrical double layer. Others have assumed a value for the diffusion coefficient, or postulated different values for clay versus clay-free rocks. We have examined the link between a widely used single estimate of τ and reff for an extensive database of sandstone samples, in which mercury porosimetry data confirm that reff is reliably determined from a modification of the Hagen-Poiseuille equation assuming that the electrical tortuosity is equal to the hydraulic tortuosity. Our database does not support the existence of one or two distinct representative diffusion coefficients but instead demonstrates strong evidence for six orders of magnitude of variation in an apparent diffusion coefficient that is well-correlated with reff and the specific surface area per unit pore volume Spor. Two scenarios can explain our findings: (1) the length scale defined by τ is not equal to reff and is likely much longer due to the control of pore-surface roughness or (2) the range of diffusion coefficients is large and likely determined by the relative proportions of the different minerals (e.g., silica and clays) making up the rock. In either case, the estimation of reff (and hence permeability) is inherently uncertain from a single characteristic IP relaxation time as considered in this study.
Reactions of dicarbonyl compounds with dimethyl .beta.-ketoglutarate: II. Simple synthesis of compounds of the [10.3.3]- and [6.3.3]-propellane series (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of dicarbonyl compounds with dimethyl .beta.-ketoglutarate: II. Simple synthesis of compounds of the [10.3.3]- and [6.3.3]-propellane seriesDaisy Yang and James M. CookCite this: J. Org. Chem. 1976, 41, 11, 1903–1907Publication Date (Print):May 1, 1976Publication History Published online1 May 2002Published inissue 1 May 1976https://doi.org/10.1021/jo00873a004RIGHTS & PERMISSIONSArticle Views258Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (726 KB) Get e-Alerts Get e-Alerts
Optical bistability in axially modulated Omniguide fibers (2004)

Through detailed computational experiments, and an analytical model, we predict optical bistability behavior at few tens of mWs in axially modulated OmniGuide fibers, using instantaneous Kerr nonlinearity. We solve the full non-linear Maxwell's equations numerically (with minimal physical approximations) to demonstrate optical bistability in a photonic crystal (PC) fiber-device.
Equine Arteritis Virus Uses Equine CXCL16 as an Entry Receptor (2016)

Outbreaks of EVA can be a source of significant economic loss for the equine industry from high rates of abortion in pregnant mares, death in young foals, establishment of the carrier state in stallions, and trade restrictions imposed by various countries. Similar to other arteriviruses, EAV primarily targets cells of the monocyte/macrophage lineage, which, when infected, are believed to play a critical role in EVA pathogenesis. To this point, however, the host-specified molecules involved in EAV binding and entry into monocytes/macrophages have not been identified. Identification of the cellular receptors for EAV may provide insights to design antivirals and better prophylactic reagents. In this study, we have demonstrated that EqCXCL16 acts as an EAV entry receptor in EAV-susceptible cells, equine monocytes. These findings represent a significant advance in our understanding of the fundamental mechanisms associated with the entry of EAV into susceptible cells.
Relay Channels (2011)

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Flipped CMOS-diaphragm capacitive tactile sensor surface mountable on flexible and stretchable bus line (2015)

The following novel configuration has been developed for a MEMS-CMOS integrated tactile sensor on a flexible and stretchable bus for covering a social robot body: a sensing diaphragm is formed on a CMOS substrate by backside etching, and the CMOS substrate is flip-bonded to a low temperature co-fired ceramic (LTCC) substrate. By this configuration, no through-silicon vias (TSVs) are needed, simplifying the fabrication process. The flipped CMOS substrate and the LTCC substrate were bonded and electrically connected using Au-Au bonding, which also formed differential capacitive gaps. A flexible and stretchable wire was fabricated by metal etching and polyimide laser cutting. The tactile sensors, which were mounted on the surface of the flexible bus, sent coded digital signals according to applied force.
TRIFUNCTIONAL LIGANDS: A RADIOIODINATED HIGH AFFINITY ACYLATING ANTAGONIST FOR THE A1 ADENOSINE RECEPTOR. (1992)

A new xanthine (adenosine antagonist) radioligand that binds covalently to A<sub>1-</sub>adenosine receptors was prepared and used as a receptor probe. BH-DITC-XAC was synthesized via a trifunctional aryl diisothiocyanate crosslinker. containing the p-hydroxyphenylpropionyl group for radioiodination. The xanthine competed against agonist or antagonist A<sub>1</sub> receptor radioligands in bovine brain membranes with an IC<sub>50</sub>, of 40nM. <sup>125</sup>I-BH-DITC-XAC, prepared directly by the chloramine T method and purified by HPLC. bound specifically to A<sub>1</sub> receptors. This binding was inhibited in the presence of the adenosine agonists <i>R</i>-PIA, <i>S</i>-PIA. and NECA in a dose dependent manner and with the order of potency characteristic of bovine A<sub>1</sub> receptors. Incubation of affinity purified bovine A<sub>1</sub>-receptors with <sup>125</sup>I-BH-DITC-XAC (0.8 nM) for 2 hours resulted in the specific and clean labelling of a polypeptide band corresponding to MW 36,000, identical to that previously found for the A<sub>1</sub> receptor.
THz Near-Field Imaging Based On A Tapered Parallel-Plates (2012)

A Broad-band low-loss no-cut-off THz near-field imaging technique has been demonstrated experimentally. Using a tapered parallel-plate waveguide as a probe this technique is able to resolve sub-wavelength (λ ~ 600 µm-6 mm) features of size ~100 µm.
Release 11 and Outlook towards Release 12 (2012)

This chapter presents the outlook towards 3GPP Release 11 and 12 with the work on-going in 3GPP. 3GPP is complementing the first long term evolution (LTE)-Advanced version, Release 10, with large number of new study and work items in Release 11. Advanced UE receiver work follows the similar activity done earlier for HSPA UE receiver. One of the interesting areas being worked at in 3GPP TSG RAN is the features for the support of machine type communications (MTC). This type of communications does not require human interaction and can be viewed as data communications between devices and a server, or device to device. Support of inter-band carrier aggregation for TDD DL and UL includes different uplink-downlink configurations on different bands. The work on the enhanced downlink control channel is referring to the enhanced PDCCH (ePDCCH) to improve the capabilities and performance of the physical layer control signaling. Controlled Vocabulary Terms downlink; long term evolution; radio receivers
A proposal of reserved channel dynamic channel assignment algorithm for multimedia mobile communication systems (2002)

We first present a mathematical model to evaluate the effect of traffic integration of broadband and narrowband services for a multimedia mobile communication system. The mathematical model gives the blocking probability for the dynamic channel assignment (DCA) scheme with both the carrier partitioning (CP) method and the carrier sharing (CS) method assuming a multi-carrier TDMA mobile communication environment. The proposed evaluation method is effective to analyze the characteristics of traffic integration, and shows that the CS method has a better performance compared with the CP method. The problem of the CS method is that narrowband traffic may cause blocking of the broadband traffic when there are a large number of channel fractions. To reduce this effect, we next propose a dynamic channel assignment algorithm based on the self adaptive channel allocation strategy which is named the reserved channel scheme. It reserves communication channels for broadband traffic by means of the frequency hopping technique to reduce the number of channel fractions. Simulation results show that the reserved channel strategy has better performance compared with the ARP (autonomous reuse partitioning) strategy.
The Cystatin-Related Epididymal Spermatogenic Protein Inhibits the Serine Protease Prohormone Convertase 2 (2003)

The cystatin-related epididymal spermatogenic (CRES) protein is related to the family 2 cystatins of the cystatin superfamily of cysteine protease inhibitors. However, CRES lacks sequences important for cysteine protease inhibitory activity and is specifically expressed in reproductive and neuroendocrine tissues. Thus, CRES is distinct from cystatins and may perform unique tissue-specific functions. The purpose of the present study was to determine whether CRES functions as a protease inhibitor in in vitro assays. In contrast to mouse recombinant cystatin C, recombinant CRES did not inhibit the cysteine proteases papain and cathepsin B, suggesting that it probably does not function as a typical cystatin. CRES, however, inhibited the serine protease prohormone convertase 2 (PC2), a protease involved in prohormone processing in the neuroendocrine system, whereas cystatin C showed no inhibition. CRES did not inhibit subtilisin, trypsin, or the convertase family members, PC1 and furin, indicating that it selectively inhibits PC2. Kinetic analysis showed that CRES is a competitive inhibitor of PC2 with a K(i) of 25 nM. The removal of N-terminal sequences from CRES decreased its affinity for PC2, suggesting that the N terminus may be important for CRES to function as an inhibitor. These studies suggest that CRES is a cross-class inhibitor that may regulate proprotein processing within the reproductive and neuroendocrine systems.
A Study of PU/MMT Nanocomposites (2009)

The polyurethane (PU)/montmorillonite (MMT) composite prepared by in situ polymerization was a sort of intercalated nanocomposite. The silicate platelets were dispersed in the PU matrix on the nanoscale. The N,N-dimethylformamide (DMF) suspension containing the PU/MMT nanocomposite was stable for a long time, and the silicate platelets did not subside. With an increasing content of silicate, the tensile and tear strength of the PU/MMT nanocomposite increased, but the rate of increase diminished. Compared with that of pure PU, the temperature of initial weight loss of the PU/MMT nanocomposite in the first step decreased because of the acid catalytic action of the protonated silicate platelets, but the temperature of initial weight loss in the second step increased due to the barrier effect of the silicate platelets and the strong interfacial interaction between silicate platelets and the molecular chains of PU.
Bcl-2 attenuates esculetin-induced apoptosis in human leukemic U937 cells through inactivation of ERK pathway (2007)

A8 Esculetin, a coumarin derivative contained in various plants, has been shown to exhibit anti-cancer effects. However, the cellular and molecular mechanism by which esculetin induced apoptosis are poorly understood. In the present study, we determined that esculetin could inhibit the cell growth of U937 cells, which was associated with apoptotic cell death such as increased populations of apoptotic-sub G1 phase, formation of apoptotic bodies, DNA fragmentation and increased the percentage of cells with depolized mitochondrial membrane. Esculetin induced apoptosis through activation of extracellular-regulated kinase (ERK) phosphorylation, up-regulation of death receptor-4 (DR4), cleavaged Bid, induced the proteolytic activation of caspases, and a concomitant degradation and/or down-regulation of poly(ADP-ribose) polymerase (PARP) and phospholipase-γ1 (PLC-γ1). Although esculetin did not alter Bcl-2 expression, overexpression of Bcl-2 were significantly attenuated the change in mitochondrial membrane potential, ERK phosphorylation, up-regulation of DR4 and caspases activation during esculetin-induced apoptosis. Furthermore, Bcl-2 specific inhibitor, HA14-1, restored esculetin-induced apoptosis through activation of ERK phosphorylation in U937/Bcl-2 cells. Thus, our findings imply that some of the biological functions of Bcl-2 may be attributed to their ability to inhibit esculetin-induced apoptosis through inhibition of ERK activation. And esculetin can be used as a new therapeutic approach for the treatment of human monocytic leukemia cells.
Coarse-Grain Model for Glucose, Cellobiose, and Cellotetraose in Water (2011)

We present a coarse-grain (CG) simulation model for aqueous solutions of β-d-glucose, cellobiose, and cellotetraose, based on atomistic simulation data for each system. In the model, three spherical beads are used to represent glucose, and a single bead is used to represent water. For glucose, the force field is calculated using force matching by minimizing the sum of the square differences between forces calculated from atomistic and CG simulations. For cellobiose and cellotetraose, we use a hybrid method where the nonbonded interactions are obtained using force matching and the bonded interactions are obtained using Boltzmann inversion. We demonstrate excellent agreement in the structural properties between the atomistic simulations and the CG simulations. This model represents the first step in developing a CG force field for cellulose, as it is of significant interest to study cellulose behavior at much longer time and length scales relative to atomistic simulations.
The Sequential Action of a Dipeptidase and a β-Lyase Is Required for the Release of the Human Body Odorant 3-Methyl-3-sulfanylhexan-1-ol from a Secreted Cys-Gly-(S) Conjugate by Corynebacteria (2008)

Human axillary odor is formed by the action of Corynebacteria on odorless axilla secretions. Sulfanylalkanols, 3-methyl-3-sulfanylhexan-1-ol in particular, form one key class of the odoriferous compounds. A conjugate with the dipeptide Cys-Gly has been reported as the secreted precursor for 3-methyl-3-sulfanylhexan-1-ol. Here, we confirm the Cys-Gly-(S) conjugate as the major precursor of this odorant, with lower levels of the Cys-(S) conjugate being present in axilla secretions. The enzymatic release of 3-methyl-3-sulfanylhexan-1-ol from the Cys-Gly-(S) conjugate by the axilla isolate Corynebacterium Ax20 was thus investigated. Cellular extracts of Ax20 released 3-methyl-3-sulfanylhexan-1-ol from the Cys-Gly-(S) conjugate and from the Cys-(S) conjugate, whereas the previously isolated C-S lyase of this bacterial strain was only able to cleave the Cys-(S) conjugate. o-Phenanthroline blocked the release from the Cys-Gly-(S) conjugate but did not affect cleavage of the Cys-(S) conjugate, indicating that in a first step, a metal-dependent dipeptidase hydrolyzes the Cys-Gly bond. This enzyme was purified by four chromatographic steps and gel electrophoresis, and the partial amino acid sequence was determined. The corresponding gene was cloned and expressed in Escherichia coli. It codes for a novel dipeptidase with a high affinity toward the Cys-Gly-(S) conjugate of 3-methyl-3-sulfanylhexan-1-ol. Co-incubating either the synthetic Cys-Gly-(S) conjugate or fresh axilla secretions with both the C-S lyase and the novel dipeptidase did release 3-methyl-3-sulfanylhexan-1-ol, proving that the sequential action of these two enzymes from the skin bacterium Corynebacterium Ax20 does release the odorant from the key secreted precursor.