gebhart/patrepeval huggingface dataset:
Anti-murine CD52 Antibody Treatment Does Not Adversely Affect the Migratory Ability of Immune Cells (P1.222) (2014)

OBJECTIVE: To evaluate the migratory properties of various immune cell populations following anti-muCD52 treatment in murine models of inflammation. BACKGROUND: Alemtuzumab is an anti-CD52 humanized monoclonal antibody that causes depletion of circulating lymphocytes followed by a distinctive pattern of repopulation. Alemtuzumab showed superior efficacy vs. subcutaneous interferon beta-1a in phase 3 trials in active relapsing-remitting multiple sclerosis patients who were treatment-naïve (CARE-MS I) or had relapsed on prior therapy (CARE-MS II). An anti-muCD52 antibody was utilized to expand our understanding of anti-CD52 therapy in mouse models of immune cell migration. DESIGN/METHODS: Immune cell migration was evaluated using both in vitro and in vivo analysis. Lymphocyte migration in vitro was evaluated in transwell assays using CD4 T cells purified from anti-muCD52-treated mice. In vivo migration was assessed using an acute CNS inflammation model in which mice were injected intracerebroventricularly with lipopolysaccharide (LPS) following anti-muCD52 treatment. Similarly, migration of innate immune cell subsets was evaluated in peritonitis model of inflammation, with animals being injected intraperitoneally with thioglycollate 3 days following anti-muCD52 treatment. The numbers of CNS-infiltrating lymphocytes or peritoneum-infiltrating cells were measured by polychromatic flow cytometry. RESULTS: Immune cells from anti-muCD52-treated mice retained their ability to migrate. In vitro, CD4 T cells were able to migrate in response to SDF-1alpha as efficiently as cells from vehicle-treated animals. In vivo, lymphocytes in anti-muCD52-treated animals were able to migrate into the CNS following local induction of inflammation by LPS. Similarly, innate immune cell migration was not affected by anti-muCD52 treatment, as similar numbers and types of cells were observed in inflamed peritoneum of anti-muCD52- and vehicle-treated animals. CONCLUSIONS: These results indicate that following anti-muCD52 treatment, immune cells retain their ability to migrate. These findings suggest that anti-muCD52 treatment may not compromise immune surveillance, but further studies are required. Study Supported by: Genzyme, a Sanofi company
Lower Corneal Temperature in Neuroleptic-Treated vs. Drug-Free Schizophrenia Patients (2003)

Antipsychotic drugs (APDs) can decrease core body temperature in schizophrenia patients. Core temperature may correlate with corneal temperature and thus, we hypothesized that neuroleptic-treated schizophrenia patients would display lower corneal temperature compared with drug-free patients. Corneal temperature of 12 typical APD-treated and 9 drug-free male schizophrenia patients was assessed using a FLIR thermal imaging camera. The APD-treated patients exhibited substantially and significantly lower corneal temperature compared with the drug-free patients (31.57 +/- 0.98 degrees C vs. 34.55 +/- 1.65 degrees C; p < 0.0001). Our results suggest that APDs may decrease corneal/core temperature in schizophrenia patients. The relevance of this finding to the pathophysiology of schizophrenia or to the antipsychotic effect of neuroleptics merit further investigation.
ChemInform Abstract: The Total Synthesis of the Annonaceous Acetogenin, Muricatetrocin C. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Multi-Camera Plenoptic Particle Image Velocimetry (2013)

Recently, plenoptic or lightfield cameras have been proposed for performing single camera three-dimensional fluid velocity field measurement due to their unique nature of recording both the spatial variation and the propagation direction of the incoming light. The combination of both the spatial and angular information of the light yields the lightfield function, which in turn can be used to create three-dimensional reconstructions. Unfortunately single camera plenoptic PIV measurements suffer from the same low angular resolution problems as do the single camera defocusing PIV and holographic PIV techniques. To increase the quality of the volumetric reconstructions a multiplicative, multiple plenoptic camera reconstruction algorithm is derived and it is shown in lightray simulations that using multiple plenoptic cameras can produce three-dimensional intensity fields with much higher fidelity to the true field than the reconstructions produced by a single camera. Moreover, the intensity fields produced using multiple plenoptic cameras have comparable or higher fidelity than those produced using tomographic PIV techniques with the same number and orientation of cameras.
Monitoring Data Usage in Distributed Systems (2013)

IT systems manage increasing amounts of sensitive data and there is a growing concern that they comply with policies that regulate data usage. In this paper, we use temporal logic to express policies and runtime monitoring to check system compliance. While well-established methods for monitoring linearly ordered system behavior exist, a major challenge is monitoring distributed and concurrent systems where actions are locally observed in the different system parts. These observations can only be partially ordered, while policy compliance may depend on the actions' actual order of appearance. Technically speaking, it is in general intractable to check compliance of partially ordered traces. We identify fragments of our policy specification language for which compliance can be checked efficiently, namely, by monitoring a single representative trace in which the observed actions are totally ordered. Through a case study we show that the fragments are capable of expressing nontrivial policies and that monitoring representative traces is feasible on real-world data.
67.4: Use of a Spatial Multiresolution Visual Model with Display Characterization and Ambient Information to Adaptively Shape the Tonescales of Mobile Displays (2010)

Abstract An image‐dependent, display‐dependent, and ambient illumination‐dependent tone‐mapping operator is developed that is driven by a human vision system model. It aims to maximize visible contrast information for the full range of display devices, from e‐paper to HDR displays. The operator weights contrast distortions according to their visibility predicted by the model of the human visual system. The distortions are minimized given a display model that incorporates ambient information to enforce constraints on the solution. A scene cut algorithm is used for video content to allow rapid tonescale changes across scenes while a temporal LPF is used to avoid visible temporal fluctuations within scenes. We discuss the differences between our method and previous approaches to the tone‐mapping problem, as well as newer tone mapping approaches that do not seek to preserve image information. This paper will especially highlight the issues important for current display technology for mobile devices.
High-affinity sequence-selective DNA binding by iridium(iii) polypyridyl organometallopeptides (2015)

We demonstrate the application of solid-phase peptide synthesis methods for the straightforward assembly of polynuclear Ir(III) organometallopeptides, and show that their oligoarginine derivatives exhibit high DNA binding affinity, sequence selectivity, and high cytotoxicity towards a set of cancer cell lines.
In vitro attachment of bilins to apophycocyanin. I. Specific covalent adduct formation at cysteinyl residues involved in phycocyanobilin binding in C-phycocyanin. (1988)

Expression of cloned alpha and beta subunit genes of Synechococcus sp. PCC7002 C-phycocyanin in Escherichia coli led to the production of large amounts of apophycocyanin. The apophycocyanin was purified to homogeneity and shown to be an alpha beta monomer. The reactivity of the apoprotein toward a number of open chain and cyclic tetrapyrroles was examined. Phycocyanobilin (PCB), phycoerythrobilin, and biliverdin all formed covalent adducts with apophycocyanin in 50 mM sodium phosphate buffer at pH 7.0. Mesobiliverdin, bilirubin, PCB dimethyl ester, protoporphyrin IX, and hemin did not react with the apoprotein. None of these tetrapyrroles reacted with 2 mM 2-mercaptoethanol, cysteine, or reduced glutathione under the same conditions. The adduct with PCB was investigated in greater detail. Its visible absorption spectrum, with a maximum at 646 nm, is more similar to that of allophycocyanin than phycocyanin. Two PCBs are bound per alpha beta monomer when the reaction is performed with excess bilin. While tryptic digestion of the adduct generates numerous bilin peptides, amino acid analysis of these chromopeptides revealed that PCB reacted specifically at alpha-Cys-84 and beta-Cys-82, two of the three cysteinyl residues that serve as the attachment sites for PCB in native phycocyanin. The major bilin peptides arising from in vitro adduct formation at each of these sites differed both in chromatographic behavior and in spectroscopic properties from the corresponding PCB peptides isolated from tryptic digests of native C-phycocyanin.
A Photoacoustic Sensor System for Time Resolved Quantification of Diesel Soot Emissions (2004)

&lt;div class="htmlview paragraph"&gt;The reduction of particulate emissions limits requires new tools for the tuning of engines and exhaust aftertreatment systems. Time-resolved monitoring of low soot emissions is a key feature for such developments. The paper describes an improved photoacoustic soot sensor, and presents its applications for the characterization of transient exhaust soot emissions before and after Diesel emission after-treatment systems. The detection limit of the unit is around 5 μg/m&lt;sup&gt;3&lt;/sup&gt; soot, which is two orders of magnitude better than conventional time-resolved transmission measurement. Additionally, a wide dynamic range of four orders of magnitude can be achieved without range switching. The photoacoustic signal is proportional to the soot mass, no significant cross-sensitivities to gaseous absorbers were detected.&lt;/div&gt;
Inositol hexakisphosphate increases the size of platelet aggregates (2018)

The inositol phosphates, InsP<sub>5</sub> and InsP<sub>6</sub>, have recently been identified as binding partners of fibrinogen, which is critically involved in hemostasis by crosslinking activated platelets at sites of vascular injury. Here, we investigated the putative physiological role of this interaction and found that platelets increase their InsP<sub>6</sub> concentration upon stimulation with the PLC-activating agonists thrombin, collagen I and ADP and present a fraction of it at the outer plasma membrane. Cone and plate analysis in whole blood revealed that InsP<sub>6</sub> specifically increases platelet aggregate size. This effect is fibrinogen-dependent, since it is inhibited by an antibody that blocks fibrinogen binding to platelets. Furthermore, InsP<sub>6</sub> has only an effect on aggregate size of washed platelets when fibrinogen is present, while it has no influence in presence of von Willebrand factor or collagen. By employing blind docking studies we predicted the binding site for InsP<sub>6</sub> at the bundle between the γ and β helical subunit of fibrinogen. Since InsP<sub>6</sub> is unable to directly activate platelets and it did not exhibit an effect on thrombin formation or fibrin structure, our data indicate that InsP<sub>6</sub> might be a hemostatic agent that is produced by platelets upon stimulation with PLC-activating agonists to promote platelet aggregation by supporting crosslinking of fibrinogen and activated platelets.
Reproducibility of Corneal Graft Thickness measurements with COLGATE in patients who have undergone DSAEK (Descemet Stripping Automated Endothelial Keratoplasty) (2012)

The analysis from the COLGATE programme can be reproducible between different observers. Care must be taken when interpreting the automated analysis as they tend to over estimate measurements.
Rh/SiO<SUB>2</SUB> Catalysts for Selective Reduction of NO with H<SUB>2</SUB> in the Presence of SO<SUB>2</SUB> and O<SUB>2</SUB> (2003)

Rh/SiO2, as well as Ir/SiO2, catalysts showed excellent activity for NO reduction with H2 in the presence of O2 and SO2. In particular, the coexistence of O2 and SO2 was essential for NO reduction to occur. FT-IR measurements of the adsorbed species on Rh/SiO2 catalyst indicated that NO adsorption was completely inhibited by SO2 in the absence of O2, but the adsorption of NO occurred on the vacant sites formed by the oxidation of SO2 to SO3 in the presence of O2. NO reduction with H2 probably proceeds via NHx intermediate species as for NH3- SCR. SiO2 was the most effective support for rhodium. Other supports such as Al2O3 were not effective, possibly because activation of H2 is hindered on more cationic rhodium (Rhδ+) due to the presence of adsorbed SO3 or NO3 species on the supports.
Feature-based similarity search in 3D object databases (2005)

The development of effective content-based multimedia search systems is an important research issue due to the growing amount of digital audio-visual information. In the case of images and video, the growth of digital data has been observed since the introduction of 2D capture devices. A similar development is expected for 3D data as acquisition and dissemination technology of 3D models is constantly improving. 3D objects are becoming an important type of multimedia data with many promising application possibilities. Defining the aspects that constitute the similarity among 3D objects and designing algorithms that implement such similarity definitions is a difficult problem. Over the last few years, a strong interest in methods for 3D similarity search has arisen, and a growing number of competing algorithms for content-based retrieval of 3D objects have been proposed. We survey feature-based methods for 3D retrieval, and we propose a taxonomy for these methods. We also present experimental results, comparing the effectiveness of some of the surveyed methods.
Generation-recombination noise in GaN/AlGaN heterostructure field effect transistors (2001)

Local levels with a large activation energy E/sub a//spl sim/0.8-1.0 eV have been observed in low-frequency noise measurements of GaN/AlGaN heterostructure field effect transistors (HFETs and MOS-HFETs) grown on 4N-SiC substrates. The noise might come from the thin (30 nm) AlGaN barrier layer. The estimates of the level parameters based on this assumption resulted in reasonable values of capture cross section /spl sigma//sub n//spl ap/(10/sup -12/-10/sup -13/) cm/sup 2/ and trap concentration N/sub t//spl ap/5-10/sup 16/ cm/sup -3/.
Work function shifts of catalytic metals under hydrogen gas visualized by terahertz chemical microscopy (2012)

Terahertz chemical microscopy (TCM) was applied to visualize the distribution of the work function shift of catalytic metals under hydrogen gas. TCM measures the chemical potential on the surface of a SiO(2)/Si/sapphire sensing plate without any contact with the plate. By controlling the bias voltage between an electrode on the SiO(2)/ surface and the Si layer, the relationship between the voltage and the THz amplitude from the sensing plate can be obtained. As a demonstration, two types of structures were fabricated on the sensing plate, and the work function shifts due to catalytic reactions were visualized.
MO816PULSE PRESSURE IS AN INDEPENDENT PREDICTOR OF THE RISK OF RECURRENT ALL-CAUSE HOSPITALIZATION IN CHRONIC HEMODIALYSIS PATIENTS (2021)

Abstract Background and Aims Pre - and peri-dialytic systolic blood pressures (SBP) have been linked to heightened cardiovascular morbidity and mortality in hemodialysis (HD) patients. High pulse pressure (PP) is clinically associated with increased arterial stiffness and atrial fibrillation, while low PP is associated with cardiac insufficiency. We studied the relationship between PP and all-cause hospitalization in patients undergoing maintenance HD. Method This retrospective cohort study was performed in HD patients from January 2015 to May 2020. To be included in the study, patients were required to be 18 or older, dialysis vintage of at least a year, and must have received treatment within the first 30 days after dialysis initiation. We developed Cox proportional hazards models with spline corrected terms for recurrent all-cause hospitalizations. 95% confidence interval (CI) were also computed. Further, we stratified the patient population into 4 SBP categories, namely: SBP &amp;lt; 120, 120 ≤ SBP &amp;lt; 150, 150 ≤ SBP &amp;lt; 180, and SBP ≥ 180 mmHg, and investigated the mediating effects of SBP on hospitalization risk. Results We studied 2453 HD patients (age 58.9±16.1 years, 58% male) dialyzed between January 2014 and October 2018 in Renal Research Institute facilities. We observe that PPs between 45 and 70 mmHg were associated with lower risk of recurrent hospitalization (Figure 1a), possibly driven by the behavior of SBPs between 120 to 180 mmHg (Figure 1c-e). No statistically significant association was seen between PP and hospitalization for patients with SPB &amp;lt;120mmHg and &amp;gt;180mm (Figures 1b-d). A decreasing trend with PP greater than 90mmHg is noted but rendered negligible, and a statistical artifact caused by a case mix at these unusually high levels. The lack of significant associations between inflammatory (NLR) and nutritional (Albumin and phosphorus) factors renders PP a significant and independent predictor of recurrent hospitalization adding to the current knowledge in the field. Conclusion Our analysis found associations between PP (with and without SBP stratification) and the risk of recurrent hospitalization and all-cause mortality. Even after adjustment for hospitalization risk and other clinical, inflammatory, and nutritional parameters at baseline PP remained an independent predictor of recurrent hospitalizations. Further investigations into the relationship are needed to better understand the mediating effects of PP as a driver of hospitalization and mortality risk.
A novel approach to oligocyclopropane structural units (1997)

A fundamentally novel approach to the synthesis of oligocyclopropane structural units based on the iterative formation and trapping of homo-allyl cationic intermediates has been accomplished. This methodology provides practical access to the diastereomically related trans-syn-trans and trans-anti-trans bis-cyclopropanes and higher homologues.
Encapsulated Solvents for Carbon Dioxide Capture (2013)

Many attractive options for carbon capture solvents suffer from high viscosity, making it difficult to generate large surface areas for fast absorption, and amine-based aqueous liquids suffer from potential environmental impacts from solvent release. As part of a US-DOE ARPA-E program, a team from the University of Illinois Urbana-Champaign, Babcock and Wilcox, and Lawrence Livermore National Laboratory have created a new encapsulated form of carbon capture solvents in which the operating fluid, amines or carbonates in our tests to date, is enclosed in a thin polymer shell forming 200-400 μm beads. While mass transport across the polymer shell is reduced compared to the neat liquid, the large surface area of the beads lessens this disadvantage. The liquid, as well as any degradation products or precipitates, remains encapsulated within the beads, which can be thermally regenerated repeatedly. Encapsulated solvents have the capacity of liquids and the physical behavior of solid sorbents. We imagine them to be useful in fairly conventional-style capture applications, as well as exotic new approaches facilitated by their high surface area. The beads appear to be both chemically and mechanically stable under typical industrial conditions. Examples of the engineering constraints that the beads must satisfy for several application strategies, including their use in fluidized beds, will be presented. To date we have encapsulated MEA, piperazine, and a variety of carbonate solutions, which appear to be optimal for this application. We have demonstrated rapid CO2 uptake and desorption using colorimetric methods, which permit rapid spectroscopic determination of the extent of CO2 uptake and release (shown to the left, loaded form is yellow). Carbonate capsules are created using a silicone polymer shell which is both rugged and permeable to CO2. Results of mechanical/thermal cycling tests demonstrate long-term stability of silicone- encapsulated carbonate.
Race, Genetic West African Ancestry, and Prostate Cancer Prediction by Prostate-Specific Antigen in Prospectively Screened High-Risk Men (2009)

"Race-specific" prostate-specific antigen (PSA) needs evaluation in men at high risk for prostate cancer for optimizing early detection. Baseline PSA and longitudinal prediction for prostate cancer were examined by self-reported race and genetic West African (WA) ancestry in the Prostate Cancer Risk Assessment Program, a prospective high-risk cohort. Eligibility criteria were age 35 to 69 years, family history of prostate cancer, African American race, or BRCA1/2 mutations. Biopsies were done at low PSA values (<4.0 ng/mL). WA ancestry was discerned by genotyping 100 ancestry informative markers. Cox proportional hazards models evaluated baseline PSA, self-reported race, and genetic WA ancestry. Cox models were used for 3-year predictions for prostate cancer. Six hundred forty-six men (63% African American) were analyzed. Individual WA ancestry estimates varied widely among self-reported African American men. Race-specific differences in baseline PSA were not found by self-reported race or genetic WA ancestry. Among men with > or =1 follow-up visit (405 total, 54% African American), 3-year prediction for prostate cancer with a PSA of 1.5 to 4.0 ng/mL was higher in African American men with age in the model (P = 0.025) compared with European American men. Hazard ratios of PSA for prostate cancer were also higher by self-reported race (1.59 for African American versus 1.32 for European American, P = 0.04). There was a trend for increasing prediction for prostate cancer with increasing genetic WA ancestry. "Race-specific" PSA may need to be redefined as higher prediction for prostate cancer at any given PSA in African American men. Large-scale studies are needed to confirm if genetic WA ancestry explains these findings to make progress in personalizing prostate cancer early detection.
BOOMERanG: balloon observations of millimetric extragalactic radiation and geophysics (1997)

The BOOMERanG experiment is an international effort to measure the Cosmic Microwave Background(CMB) anisotropy at an angular resolution of 12÷20 arcmin, with unprecedented sensitivity, sky and spectral coverage. The telescope will be flown from Antarctica by NASA-NSBF with a long duration stratospheric balloon (7 - 14 days), and is presently scheduled for a test flight in 1996 and an Antarctic flight in 1997. The experiment is designed to measure the power spectrum of the CMB anisotropies up to l ≡ 700 and to produce an image of the CMB sky with high sensitivity and angular resolution. It will be an important precursor of future space-borne missions, producing crucial cosmological data and testing new technologies which are essential to the design of a CMB mapping satellite experiment.