gebhart/patrepeval huggingface dataset:
A Derivative of Cationic Antimicrobial Protein Attenuates Lung Injury by Suppressing Cell Adhesion (1996)

Cationic antimicrobial protein of 18 kD (CAP18) was identified and purified from rabbit granulocytes and shown to inhibit various activities of lipopolysaccharide (LPS). We investigated the effect of a 32-amino-acid C-terminal fragment of CAP18 (CAP18-derived peptide, CDP) on the pathogenesis of acute lung injury caused by intravenous endotoxin. Guinea pigs were divided into six groups: (I) saline control (n = 8), (2) CDP-alone (n = 8), (3) LPS-alone (n = 8), (4) LPS+CDP0m (n = 8), (5) LPS+CDP10m (n = 8), and (6) LPS+CDP60m (n = 8). A CDP dose of 0.2 mg/kg was injected at various time points after LPS injection. Lung wet-to-dry weight ratio, [125I]albumin leakage in lung tissue and bronchoalveolar lavage (BAL) fluid, differential cell count in BAL fluid, and histopathologic features were examined 4 h after intravenous administration of 0.02 mg/kg of LPS. The LPS+CDP0m and the LPS+CDP10m groups showed significantly attenuated lung injury compared to that seen in the LPS-alone group, however the LPS+CDP60m group revealed no attenuation of lung injury. The accumulation of peripheral white blood cells into pulmonary vasculature was attenuated only in the LPS+CDP0m but not in the LPS+CDP10m groups. We examined the effect of CDP on the expression of adhesion molecules using human umbilical vein endothelial cells, the result of which showed that CDP suppressed the LPS-induced expression of adhesion molecules in a dose-dependent manner. We conclude that CDP attenuates inflammatory cell migration into alveoli resulting in the attenuation of lung injury.
SYNOVIAL FLUID METAL LEVELS ARE SUPERIOR TO WHOLE BLOOD AND SERUM METAL ION LEVELS IN PREDICTING LOCAL TISSUE DESTRUCTION IN FAILED HIP ARTHROPLASTY CONSTRUCTS (2018)

Serum and blood cobalt (Co) and chromium (Cr) ion levels are used to monitor patients at risk for adverse reaction to metal debris (ARMD) following metal-on-metal (MoM) total hip arthroplasty (THA)...
ChemInform Abstract: Reversible Carbon Monoxide Addition to Sol‐Gel Derived Composite Films Containing a Cationic Rhodium(I) Complex: Toward the Development of a New Class of Molecule‐Based CO Sensors. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Cardiovascular Biomarkers in Preeclampsia at Triage (2014)

Assessment of the cardiovascular plasma biomarkers MR-proANP and MR-proADM holds promise to support diagnosis of PE at triage.
A new optical method for the non-invasive detection of minimal tissue alterations (2002)

Histological analysis, which is used to detect and diagnose most tissue alterations, requires an invasive biopsy procedure and a time-consuming tissue treatment, which limit its efficiency in providing rapid, cost-effective diagnosis and hinder the longitudinal study of tissue alteration. To address these limitations, we have developed a novel procedure, using the features of elastic-scattering spectroscopy, for a real-time, non-invasive analysis of tissues. We have tested whether this approach can detect in vivo changes in mouse skin induced by a single exposure to either complete Freund's adjuvant or 12-O-tetradecanoylphorbol-13-acetate, two drugs known to induce discrete alterations of epidermis and dermis, without obvious changes on the skin surface. Here we report that the evaluation of localized absorption and reduced scattering coefficients permitted the detection of changes in skin regions that showed histological alterations, but not in regions which failed to be modified by the drugs. Results show that the optical in vivo analysis of small regions has sufficient specificity and sensitivity to detect minimal alterations of superficial tissues. In view of the prominent involvement of mucosal alterations in most human diseases, including carcinomas, the method provides a useful complement to standard biopsy, notably for the in vivo screening of early in situ epithelial alterations.
Passive millimeter wave spectrometer for remote detection of chemical plumes (2023)

Systems and methods for the passive measurement of spectral lines from the absorption or emission by polar molecules. The system includes mmW front-end assembly, back-end electronics, and data acquisition hardware and software was assembled. The method relates to methods for processing multi-channel radiometric data from passive mmW detection systems.
Growth Hormone Receptor Antagonist Transgenic Mice Are Protected From Hyperinsulinemia and Glucose Intolerance Despite Obesity When Placed on a HF Diet (2014)

Reduced GH levels have been associated with improved glucose metabolism and increased longevity despite obesity in multiple mouse lines. However, one mouse line, the GH receptor antagonist (GHA) transgenic mouse, defies this trend because it has reduced GH action and increased adiposity, but glucose metabolism and life span are similar to controls. Slight differences in glucose metabolism and adiposity profiles can become exaggerated on a high-fat (HF) diet. Thus, in this study, male and female GHA and wild-type (WT) mice in a C57BL/6 background were placed on HF and low-fat (LF) diets for 11 weeks, starting at 10 weeks of age, to assess how GHA mice respond to additional metabolic stress of HF feeding. On a HF diet, all mice showed significant weight gain, although GHA gained weight more dramatically than WT mice, with males gaining more than females. Most of this weight gain was due to an increase in fat mass with WT mice increasing primarily in the white adipose tissue perigonadal depots, whereas GHA mice gained in both the sc and perigonadal white adipose tissue regions. Notably, GHA mice were somewhat protected from detrimental glucose metabolism changes on a HF diet because they had only modest increases in serum glucose levels, remained glucose tolerant, and did not develop hyperinsulinemia. Sex differences were observed in many measures with males reacting more dramatically to both a reduction in GH action and HF diet. In conclusion, our findings show that GHA mice, which are already obese, are susceptible to further adipose tissue expansion with HF feeding while remaining resilient to alterations in glucose homeostasis.
Deformability of cord blood vs. newborns’ red blood cells: implication for blood transfusion (2021)

This study supports the notion that treating PN with transfusion of adults' PRBC has the potential to introduce a circulatory risk to the recipients, while CB-RBC, with their superior deformability, provides a safer and more effective PN-specific transfusion therapy.
Steroids (2005)

Abstract Structure and Nomenclature Classification of Biologically Active, Natural Steroids Biosynthesis Manufacture and Synthesis Partial Syntheses Uses: Therapeutics and Toxicology Analytical Methods
Advancing carbon management through the global commoditization of CO2: the case for dual-use LNG-CO2 shipping (2020)

Rising anthropogenic CO2 emissions and global temperatures are a technological, social, and political challenge. These necessitate deep decarbonization through carbon management strategies for sustained climate action. Cost-effective transportation of CO2 from point sources to utilization and storage sites is a significant bottleneck for at-scale carbon management. A new mechanism to achieve international cooperation on carbon management through effective CO2-source and CO2-use or sequestration matching is addressed in this paper. The mechanism is founded on utilizing the growth of global LNG trade to transport CO2 over long distances via dual-use vessels that carry CO2 on their return journey following LNG delivery. A foundational carbon capture, utilization, and storage (CCUS)-based economic model for the utilization of CO2 originating in South Korea and Japan via enhanced oil recovery (EOR) in the offshore U.S. is explored. The model sets forth the objectives, scale, costs, and implications for the international trade and commoditization of CO2, as against its current status of a waste product. Further, policy frameworks that can accelerate the international trade of CO2 via this dual-use shipping model are discussed.
Fluorescence excitation and propagation through brain phantom gelatins: measurements and potential applications (2010)

We have investigated the utility of 0.6% agarose gels as surrogate materials for brain tissues in optical propagation studies for possible diagnostic and therapeutic applications. Centimeter-scale layers of the gel exhibited a Beer's law attenuation factor, δ, of ≈0.2 mm−1 for incident illumination via a pulsed LED (100 Hz) at 405 nm. This result was different by only about a factor of 3 from the effective penetration depth at similar wavelengths through in vitro samples of the gray (cortical) matter of human brain, as measured by others. Then, films of the thermographic phosphors La2O2S:Eu, Mg4FGeO6:Mn, YAG:Cr and variants of the latter were formed on aluminum substrates and the fluorescence of these samples was stimulated and observed through layers of the gel up to 4 cm thick. In all cases, the fluorescence was easily excited and distinguishable above the background. The results demonstrate that this gel might serve as an inexpensive and robust test bed for exploratory studies of neurological modalities involving propagation of optical signals within brain tissues.
Utility of ultrasonography in guiding modification of disease modifying anti‐rheumatic drugs and steroid therapy for inflammatory arthritis in routine clinical practice (2016)

By clarifying joint inflammation in an IA cohort with overall low ESR, ultrasonography of physician-selected joints can improve clinical assessment, resulting in treatment modification. Positive PD findings were particularly influential, while the clinical significance of GS positivity alone requires further investigation.
Adaptive processing methods for MIMO radar experimental signals (2014)

MIMO radar is a promising concept and many theoretical studies have demonstrated its interest. The colored transmission makes it possible to extract each waveform and form the transmission beam by digital processing on receive. One strong limitation of this technique is that waveforms cannot be perfectly separated in practice, because of the intrinsic lack of orthogonality of the waveforms family or hardware defaults. In case of conventional radar processing, this badly impacts the performance on target detection and localization. In this paper, we explain in which way the usual approach of adapted filter is not adapted for MIMO radar signals. Then, we introduce different approaches to estimate the target amplitude based on adaptive processing, and we deal with their performance and limitations when applied in the context of non perfectly orthogonal waveforms. We especially focus on Orthogonal Matching Pursuit (OMP) procedure which aims at detecting and cleaning each target, successively. We point out the problematic effects due to the granularity of the target amplitude grid and neighbor targets influence. To solve the problem, we propose, at each step of the OMP procedure, not only to clean the estimated position of the target, but also the close neighbor positions. We demonstrate that this “extended rejection” increases the robustness of OMP on realistic MIMO waveforms. Eventually, we apply and compare the classical, IAA (Iterative Adaptive Approach) and OMP approaches on experimental MIMO signals.
Optimizing channel coding for orthogonal multiple access schemes with correlated sources (2009)

In this paper, we consider multiple access schemes with correlated sources. Distributed source coding is not used; rather, the correlation is exploited at the access point (AP). In particular, we assume that each source uses a channel code to transmit, through an additive white Gaussian noise (AWGN) channel, its information to the AP, where component decoders, associated with the sources, iteratively exchange soft information by taking into account the correlation. The key goal of this paper is to investigate whether there exist optimized channel codes for this scenario, i.e., channel codes which guarantee a desired performance level (in terms of average bit error rate, BER) at the lowest possible signal-to-noise ratio (SNR). A two-dimensional extrinsic information transfer (EXIT) chart-inspired optimization approach is proposed. Our results suggest that by properly designing serially concatenated convolutional codes (SCCCs), the theoretical performance limits can be approached better than by using parallel concatenated convolutional codes (PCCCs) or low-density parity-check (LDPC) codes. It is also shown that irregular LDPC codes tend to perform better than regular LDPC codes, so that the design of appropriate LDPC codes remains an open issue.
SYNTHESIS OF PROTECTED SECRETIN16–27 ON A MERRIFIELD RESIN (1980)

The partially protected dodecapeptide to secretin, H-Ser(Bzl)-Ala-Arg(Tos)-Leu-Gln-Arg(Tos)-Leu-Leu-Gln-Gly-Leu-Val-NH2 (protected secretin 16-27) was prepared using a standard Merrifield resin and solid phase synthesis methods. For comparative purposes the unprotected peptide also was prepared on a benz-hydrylamine resin. Contrary to previous reports, the valine C-terminal peptide can be cleaved from the resin and the amide obtained in high yield. A variety of conditions were examined to accomplish the cleavage of the peptide from the resin in its carboxamide terminal form. The best conditions found were trans-esterification followed by ammonolysis in a mixed solvent system. A thin-layer chromatography system which clearly separates the methyl ester and carboxamide terminal secretin 16-27 was developed.
[Three-dimensional Structure of eIF2B: A Clue to Understanding the Pathogenesis of CACH/VWM Disease]. (2017)

CACH/VWM (childhood ataxia with central nervous system hypomyelination/vanishing white matter) disease is caused by mutations in the genes encoding the subunits of eukaryotic initiation factor 2B (eIF2B), but its etiology is poorly understood. Here, we attempt to provide an explanation for the pathogenic mechanism of this disease, based on the crystal structure of eIF2B.
Modeling the imaging performance of prototype organic x‐ray imagers (2007)

A unified Monte Carlo and cascaded systems model for the simulation of active-matrix flat-panel imagers is presented. With few input parameters, the model simulated the imaging performance of previously measured flat-panel imagers with reasonable accuracy. The model is used to predict the properties of conceptual flat-panel imagers based on organic semiconductors on plastic substrates. The model suggests that significant improvements in resolution and detective quantum efficiency could be achieved by operating such a detector in a back-side illuminated configuration, or by employing two imaging arrays arranged face-to-face. The effect of semiconductor properties on the conceptual imagers is investigated. According to the model, a photodiode quantum efficiency of 25% and dark current of less than 100 pA mm(-2) would be satisfactory for a prototype imager, while a competitive imager would require a photodiode quantum efficiency of 40-50% with a dark current of less than 10 pA mm(-2) to be quantum limited over the radiographic exposure range.
ChemInform Abstract: Ruthenium‐Catalyzed Dimerization of Terminal Alkynes Initiated by a Neutral Vinylidene Complex. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Evaluation of Micronized Ilmenite as Weighting Material in Water-Based Drilling Fluids for HPHT Applications (2012)

Abstract Barite is the most common weighting material for drilling fluids, which contain several heavy components including lead, cadmium, mercury, and arsenic. Some of these heavy materials can discharge into the sea, which is not allowed especially in the case of oil-based drilling fluid. The supply of barite is geographically limited, with high transportation costs. To overcome the high cost, shortage, and common problems of barite, an alternative weighting material, ilmenite (5 µm), is introduced which is heavier than barite and more stable at high temperature. Also, the micronized ilmenite was introduced to overcome the ECD challenges in some drilling operations at reasonable cost. Extensive lab work was done in order to: 1) optimize the rheological properties of the drilling fluid, 2) determine the optimum pH that gives stable dispersion, 3) assess the thermal stability, 4) optimize the filtration parameters (filtrate volume and filter cake thickness), and 5) characterize the ilmenite-based filter cake. Zeta potential results showed that ilmenite was stable when mixed with water at a pH above 7 and it was dispersed and stable when mixed with the drilling fluid components. Drilling fluids have a density range from 100 to 120 pcf and a plastic viscosity of 28–32 cp. No phase separation was observed after hot rolling for 16 hrs at 300°F. The optimized water-based drilling fluid formula had a small filtrate volume (12 cm3) and thin filter cake (0.2 in.) under dynamic conditions. SEM analysis showed that ilmenite filter cake was heterogeneous and contained ilmenite particles in the layer closer to the rock surface. The layer closer to the drilling surface had a mixture of xanthan gum and modified starch, which were used to optimize the rheological properties at 250°F. This study will provide a complete evaluation of the drilling fluids with ilmenite as a weighting material and will help drilling engineers to better design drilling fluids for HPHT wells.
A Union Bound on the Error Probability of Binary Codes Over Block-Fading Channels (2005)

Block-fading is a popular channel model that approximates the behavior of different wireless communication systems. In this paper, a union bound on the error probability of binary-coded systems over block-fading channels is proposed. The bound is based on uniform interleaving of the coded sequence prior to transmission over the channel. The distribution of error bits over the fading blocks is computed. For a specific distribution pattern, the pairwise error probability is derived. Block-fading channels modeled as Rician and Nakagami distributions are studied. We consider coherent receivers with perfect and imperfect channel side information (SI) as well as noncoherent receivers employing square-law combining. Throughout the paper, imperfect SI is obtained using pilot-aided estimation. A lower bound on the performance of iterative receivers that perform joint decoding and channel estimation is obtained assuming the receiver knows the correct data and uses them as pilots. From this, the tradeoff between channel diversity and channel estimation is investigated and the optimal channel memory is approximated analytically. Furthermore, the optimal energy allocation for pilot signals is found for different channel memory lengths.
Sequence Kernels for Speaker and Speech Recognition (2009)

AURORA 2 small vocabulary digit string recognition task– whole-word models, 16 emitting-states with 3 components per state– clean training data for HMM training - HTK parameterisation– SVMs trained on subset of multi-style data - Set A N2-N4, 10-20dB SNR– Set A N1 and Set B and Set C unseen noise conditions– Noise estimated in a ML-fashion for each utterance
Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression (2023)

The development of transgenic mouse models that express genes of interest in specific cell types has transformed our understanding of basic biology and disease. However, generating these models is time- and resource-intensive. Here we describe a model system, SELective Expression and Controlled Transduction In Vivo (SELECTIV), that enables efficient and specific expression of transgenes by coupling adeno-associated virus (AAV) vectors with Cre-inducible overexpression of the multi-serotype AAV receptor, AAVR. We demonstrate that transgenic AAVR overexpression greatly increases the efficiency of transduction of many diverse cell types, including muscle stem cells, which are normally refractory to AAV transduction. Superior specificity is achieved by combining Cre-mediated AAVR overexpression with whole-body knockout of endogenous Aavr, which is demonstrated in heart cardiomyocytes, liver hepatocytes and cholinergic neurons. The enhanced efficacy and exquisite specificity of SELECTIV has broad utility in development of new mouse model systems and expands the use of AAV for gene delivery in vivo.
Surveiller le port : le cas de Naples au xviiie siècle (2018)

Avant le développement du chemin de fer, le port représente l’interface privilégiée des phénomènes d’échanges de toute nature dans les villes côtières. Souvent, il est le premier espace de contact terrestre pour celui qui arrive, et le dernier pour celui qui part. En outre, le port implique un système d’infrastructures (douanes, fondouks, lazarets, entrepôts, etc.) en capacité d’influencer la toponymie de la ville elle-même : en effet, « Port » est fréquemment le nom d’un quartier. Le va-et-v...
Sample path large deviations for the randomly sampled continuous-discrete Kalman filter (2010)

The paper studies the problem of optimal mean squared error (m.m.s.e.) estimation of a multidimensional linear diffusion from observations of a marked point process. It is shown that, under appropriate signal-to-noise ratio scaling, the family of random conditional error covariance processes satisfies a sample large deviation principle (LDP) with good rate function as the sampling rate γ̅ → ∞. The LDP regime considered involves increasing the observation sampling rate and a proportionate decrease in the observation signal-to-noise ratio. In particular, we show that as γ̅ → ∞, the family of continuous-discrete filters converge in distribution to a filter with continuous diffusion type observations, thus verifying the robustness of the Kalman filter with respect to (w.r.t.) the observation path. We explicitly characterize the LDP rate function, quantifying the best decay rate for rare events as γ̅ → ∞. The large deviations framework developed in this work is of independent interest and applicable to larger classes of jump processes.
A New Generation of SiC Schottky Diodes with Improved Thermal Management and Reduced Capacitive Losses (2010)

With the help of an improved die attach the Rth,jc of SiC Schottky diodes can be reduced by 40-50% at a given chip size. This enables a significant higher power density for these SiC diode chips, resulting in a chip shrink of ~ 35% for a given nominal current. This has a significant impact not only on the cost position of the device but also on the switching performance of the diodes, as their capacitive charge directly scales with the chip area. Of course these advantages are accompanied by a small penalty in static losses as the Vf of the diodes at nominal current also slightly increases by the chip shrink. However, the reduction of switching losses dominates upon the marginally increased static losses besides full load operation conditions (which are pretty exceptional in today’s SiC Schottky diode applications) combined with frequencies below 130 kHz. This allows a better competitive positioning against fast Si-based diodes and improved system efficiency at the same time.