gebhart/patrepeval huggingface dataset:
X-linked vacuolar myopathies: Two separate loci and refined genetic mapping (2000)

X-linked vacuolar myopathies can be divided into two forms: one that is associated with cardiomyopathy and mental retardation (XVCM-MR) and a second form, termed X-linked myopathy with excessive autophagy (XMEA), that spares cardiac muscle and has no central nervous system involvement. In this article, we demonstrate linkage between XMEA and markers on chromosome Xq28 and assign the XMEA gene locus to the most telomeric 10.5 cM of chromosome X. We also show that XVCM-MR is not allelic to XMEA.
"Lid-on" and "lid-off" diastereoisomers of lacunar macrobicyclic complexes as identified by carbon-13- and proton-coupled carbon-13 NMR spectroscopy (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT"Lid-on" and "lid-off" diastereoisomers of lacunar macrobicyclic complexes as identified by carbon-13- and proton-coupled carbon-13 NMR spectroscopyNorman Herron, Dennis L. Nosco, and Daryle H. BuschCite this: Inorg. Chem. 1983, 22, 20, 2970–2971Publication Date (Print):September 1, 1983Publication History Published online1 May 2002Published inissue 1 September 1983https://pubs.acs.org/doi/10.1021/ic00162a045https://doi.org/10.1021/ic00162a045research-articleACS PublicationsRequest reuse permissionsArticle Views18Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ozonation of carbamazepine and its main transformation products: product determination and reaction mechanisms (2020)

Carbamazepine (CBZ) is a recalcitrant pharmaceutical often detected in wastewater and in the environment. CBZ can be removed from wastewater through advanced oxidation treatment methods such as ozonation. In this study, CBZ and its transformation product 1-(2-benzaldehyde)-(1H,3H)-quinazoline-2,4-dione (BQD) were ozonated, and the formation and transformation of their ozonation products were investigated using liquid chromatography coupled to ion trap mass spectrometry and high-resolution mass spectrometry as well as nuclear magnetic resonance (NMR). The main products, 1-(2-benzaldehyde)-4-hydro-(1H,3H)-quinazoline-2-one (BQM) and BQD were quantified using isolated standards and LC-UV. Of the original CBZ concentration, 74% was transformed into BQM and 83% of BQM was further transformed into BQD. Both products are more stable than CBZ and could still be detected after 240 min of ozonation. Another major product, 2,2'-azanediyldibenzaldehyde (TP225) was for the first time identified using NMR. Twelve further CBZ products were identified.
Inverse Design of LCN Films for Origami Applications Using Topology Optimization (2014)

Liquid crystal polymer networks (LCNs) have unique advantages as potential constituents of origami-based smart materials due to their reversible actuations and availability of fabrication techniques to create complex strain fields. Although identifying functional designs is crucial in making use of this technology, conventional approaches have largely consisted of trial-and-error experimentation. We introduce an inverse design procedure based on a topology optimization method to map out an LCN pattern with a desired spontaneous strain field to achieve prescribed shapes. In this study, we focus on a target deformation of a film to create an improved hinge to be integrated into an origami structure. Our preliminary results indicate the potential of using computational tools to determine what designs yield desired functionalities and how to best pattern LCN films to achieve them.
Single-mode dispersion-shifted fibers with effective area over 100 μm/sup 2/ (2002)

We have designed and fabricated single-mode dispersion-shifted fibers with effective area as large as 120 /spl mu/m/sup 2/ in the 1550-nm window and good bending performance using a ring-type index profile with a depressed center. The effective area is always significant larger than the mode-field area.
Testing the Critical Size in Calvarial Bone Defects: Revisiting the Concept of a Critical-Size Defect (2010)

These results suggest that calvarial bone healing is not well described and much more data need to be collected. Also, after a review of the existing literature and a critique of the clinical applicability of the model, it is suggested that the use of the term "critical-size defect" be discontinued.
Manufacturing of perovskite thin films using liquid delivery MOCVD (1995)

Abstract There are numerous ternary and quaternary oxides that are attractive for use in advanced IC's. These include Ba1-xSrxTiO3 (BST), Pb1-xLax(Zr1-yTiy)1-x/4O3 (PLZT) and SrBi2Ta2O9. Although each application has unique material requirements, in most cases the deposition process must have good conformality, composition control and throughput, while minimizing the thermal budget. For these reasons, metalorganic chemical vapor deposition (MOCVD) is acknowledged as the leading candidate for manufacturing. The absence of volatile (and in some cases stable) precursors has stimulated the use of the ‘‘liquid delivery technique'’ for transport of a system of precursors in liquid solution, which are vaporized simultaneously. Film composition is easily varied by mixing component solutions which contain one or more of the metalorganic compounds. The paper will focus on the role of measurement and control of film composition in the development of a manufacturing process for perovskites and related materials. Select results for BST and PZT thin films deposited using liquid delivery CVD will be discussed.
Determination of the Lumped-Capacitance Parameters of Air-Cooled Servers Through Air Temperature Measurements (2014)

Computer servers can be represented by lumped thermal capacitances for the purpose of simulating server and data center transient thermal response to changes in operating conditions or equipment failures. Two parameters are needed to characterize the transient behavior of a lumped-capacitance server: its thermal capacitance and its thermal conductance, heat transfer effectiveness, or time constant. To avoid the laborious task of obtaining these parameters from measurements or estimations of the thermal characteristics of internal components of the server, a method is proposed to derive these parameters from external measurements that can be easily obtained without performing an “autopsy” on the server. In this paper, we present the mathematical formulation underlying the proposed method and describe how the parameters are to be obtained from external air-temperature measurements using the mathematical model. We then present validation test cases using experimental data from server shut-down and inlet-temperature ramp tests. The experimentally obtained parameters are implemented into a computational fluid dynamics (CFD) case study of server shutdown in which the transient server exit air temperature is computed from the lumped-capacitance parameters via a user-defined function. The results thus obtained are in excellent agreement with the experimental data.
Incidence of symptomatic Covid‐19 infections in patients with mastocytosis and chronic myeloid leukemia: A comparison with the general Austrian population (2022)

Our data show no significant difference in the prevalence of Covid-19 infections among patients with mastocytosis, CML, and the general Austrian population and thus, in mastocytosis, the risk of a Covid-19 infection was not increased compared to the general population.
HeRO: A space-based low frequency interferometric observatory for heliophysics enabled by novel vector sensor technology (2018)

HeRO (Heliophysics Radio Observer) is a hybrid ground and space mission concept for radio interferometry of solar radio bursts. The space segment (HeRO-S) covers low frequencies, 100 kHzâ20 MHz, and is composed of 6 freeâflying Cube- Sats equipped with vector sensors. The ground segment (HeRO-G), covers higher frequencies, 15 MHzâ300 MHz. HeRO will explore conditions and disturbances in a key region of the heliosphere, from two to tens of solar radii, using interferometric observations of solar radio bursts over three decades in frequency. Spot mapping across the full frequency range will provide precise positions and basic structural information about type II and III radio bursts. The morphology of CME shock fronts will be traced via type II burst emissions, and heliospheric magnetic field geometries will be probed by measuring precise trajectories of type III bursts. Refraction in the heliospheric plasma on large and intermediate scales will be investigated throughout large volumes via the frequency dependence of accurate interferometric positional data on bursts. The HeRO data will be information rich with high resolution in time, frequency and spatial position, and high SNR, creating fertile ground for discovery of new phenomena.
[Recent advances in retinoids studies]. (1988)

Retinoids are defined as the compounds which elicit the specific biological responses through binding or activating the specific receptor(s). Retinoids modulate the cellular differentiation and proliferation in many types of cells. A series of retinoidal benzoic acids, named retinobenzoic acids, have potent activities on human promyelocytic leukemia cells, HL-60, and other assay systems. Among them, Am80, AM580 and Ch55 are more active than retinoic acid in most cases. As these compounds possess quite different structures or physicochemical properties from retinoic acid or conventional retinoids, they are expected to be applied clinically for the treatments of the diseases in oncology and dermatology. Recently, progresses on the mechanistic studies on retinoidal actions have been reported. One of them is isolation and cloning of human retinoic acid-receptors and the mechanism of retinoidal action was concluded that the retinoid-receptor complex interact directly with DNA to regulate the expression of the gene, like steroid hormone. The other is the establishment of the presence of the retinoid-specific-binding protein (RSBP) by the use of our retinobenzoic acids as the probe.
Progressive degeneration of nonphosphorylated neurofilament protein‐enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease: Stereologic analysis of prefrontal cortex area 9 (2003)

We performed a stereologic analysis of a subset of pyramidal neurons known to be vulnerable in Alzheimer's disease (AD) and characterized by particularly high somatodendritic levels of nonphosphorylated neurofilament protein. In the neocortex, these large pyramidal neurons reside in the deep part of layer III (layer IIIc) and the superficial part of layer V (layer Va). We focused on prefrontal cortex area 9 in elderly control cases in comparison to cases with different degrees of cognitive dysfunction. The results confirmed that these neurons are preferentially vulnerable in AD, as their numbers decrease dramatically in cases with definite dementia, correlating strongly with the severity of the disease, to a nearly complete loss (>90%) in the endstages of AD. Furthermore, a triple-labeling experimental paradigm revealed that these particular neurons are far more likely to develop neurofibrillary tangles (NFT) and do so at a faster rate than other pyramidal cells. Nonphosphorylated neurofilament protein-rich neurons also shrink considerably during formation of NFT and the largest among them are preferentially affected. Laminar differences in the severity of these effects were observed, layer Va being more severely affected, possibly correlating with the involvement of specific cortical projections. These data reveal that different populations of neurons prone to NFT formation are lost at different rates in AD, and that nonphosphorylated neurofilament protein-enriched neurons emerge as a strikingly vulnerable subpopulation of neurons. Their preferential involvement suggests that neurons providing specific corticocortical connections between association areas are at high risk for degeneration in AD.
Human Renal Normal, Tumoral, and Cancer Stem Cells Express Membrane-Bound Interleukin-15 Isoforms Displaying Different Functions (2015)

Intrarenal interleukin-15 (IL-15) participates to renal pathophysiology, but the role of its different membrane-bound isoforms remains to be elucidated. In this study, we reassess the biology of membrane-bound IL-15 (mb-IL-15) isoforms by comparing primary cultures of human renal proximal tubular epithelial cells (RPTEC) to peritumoral (ptumTEC), tumoral (RCC), and cancer stem cells (CSC/CD105(+)). RPTEC express a 14 to 16 kDa mb-IL-15, whose existence has been assumed but never formally demonstrated and likely represents the isoform anchored at the cell membrane through the IL-15 receptor α (IL-15Rα) chain, because it is sensitive to acidic treatment and is not competent to deliver a reverse signal. By contrast, ptumTEC, RCC, and CSC express a novel N-hyperglycosylated, short-lived transmembrane mb-IL-15 (tmb-IL-15) isoform around 27 kDa, resistant to acidic shock, delivering a reverse signal in response to its soluble receptor (sIL-15Rα). This reverse signal triggers the down-regulation of the tumor suppressor gene E-cadherin in ptumTEC and RCC but not in CSC/CD105(+), where it promotes survival. Indeed, through the AKT pathway, tmb-IL-15 protects CSC/CD105(+) from non-programmed cell death induced by serum starvation. Finally, both mb-IL-15 and tmb-IL-15 are sensitive to metalloproteases, and the cleaved tmb-IL-15 (25 kDa) displays a powerful anti-apoptotic effect on human hematopoietic cells. Overall, our data indicate that both mb-IL-15 and tmb-IL-15 isoforms play a complex role in renal pathophysiology downregulating E-cadherin and favoring cell survival. Moreover, "apparently normal" ptumTEC cells, sharing different properties with RCC, could contribute to organize an enlarged peritumoral "preneoplastic" environment committed to favor tumor progression.
Coulomb-induced emission dynamics and self-consistent calculations of type-II Sb-containing quantum dot systems (2012)

This paper investigates the effects of Coulomb interactions on the emission dynamics of Sb-containing quantum dot (QD) systems under high excitation densities. Two different type-II confinements are studied: confined electrons with unconfined holes using InAs/GaAs QDs capped with a GaAsSb quantum well (type-IIa), and confined holes with unconfined electrons using GaSb/GaAs QDs capped with an InGaAs quantum well (type-IIb). Time-resolved photoluminescence experiments are compared with self-consistent numerical calculations using an 8-band k\ifmmode\cdot\else\textperiodcentered\fi{}p model. In both structures, we observe a significant blueshift of emission and wavelength-dependent radiative lifetimes, but with marked quantitative differences between the two systems: in the type-IIa, the blueshift is 12 meV with a change in lifetime from 1.4 ns to 2.0 ns, and in the type-IIb, the blueshift is 63 meV with lifetime change from 100 ps to 23 ns. We present a comprehensive explanation of all the important features of the experimental data in terms of Coulomb-induced changes to the carrier wave functions and confining potentials, with the separate confinement of the electrons and holes being a crucial factor.
ASTM B 117 Screening of Nonchromate Conversion Coatings on Aluminum Alloys 2024, 2219, 5083, and 7075 Using DoD Paint Systems (2003)

This study examines corrosion resistance of eight nonchromate conversion coatings vs. bexavalent chromium based Alodine 1200S controls on scribed coated test panels of aluminum alloys 2024, 2219, 5083, and 7075. Five representative Department of Defense primer/topcoat organic coating systems were evaluated for each of the conversion coating/alloy combinations. Scribed panels were exposed using ASTM B 117 (neutral salt fog) for 3000 hr and were photographed and measured at 1, 2, and 3 weeks. Subsequent measurements were taken every 500 hr until "3000 hr" was reached or until failures from scribe creepback and/or via blistering occurred using method ASTM D 1654. Differences in pretreatment performance based upon variation in coating type as well as alloy were noted. Relationships between data from this study and data collected from previous cyclic acceleration corrosion exposure and how they may relate with respect to implementation of nonchromate pretreatments for various military applications are discussed.
Characterization of ripplocation mobility in graphite (2019)

Recent work suggests that layered solids deform through buckling of basal planes. When isolated locally, as in graphite, these buckles, termed ripplocations, behave superficially similar to dislocations, but have no Burgers vectors. Through atomistic simulations, we demonstrate the easy transitions of ripplocations in graphite between many closely-spaced energy states, even at low temperatures. Between 60 and 350 K, their migration barrier is estimated at 32 meV, independent of segment length. Ripplocations spontaneously migrate towards vacancies and away from compressive stresses. These results shed more light on this new micromechanism and potentially explain experimental observations that evade sufficient description through dislocation-based models.
Modelling Ediacaran metazoan–microbial reef growth (2020)

Abstract Throughout the Phanerozoic, sessile metazoans grew in close association with various microbial carbonates to form reefs. The first metazoans with calcareous hard‐parts appeared in the terminal Ediacaran, ca 550 million years ago, and these also commonly grew associated with microbial mats, thrombolites and stromatolites, to form the oldest known metazoan–microbial reefs. These hard‐parts also formed the first skeletal (bioclastic) carbonate sediments, which increased to dominate shallow marine carbonate sedimentary production during the Phanerozoic. Here the growth dynamics and sedimentary interactions between Ediacaran microbial–metazoan reefs and their bioclastic products are described based on reef complexes from the Nama Group, Namibia ( ca 547 Ma), and the first three‐dimensional numerical models are constructed to parametrize these dynamics. These reefs are observed to form large domal mounds and columns neighbouring locally high rates of bioclastic sediment accumulation, and commonly evolve to flat‐topped surfaces overlain by sediment. This model is parsimonious, embodying a single dynamic rule: metazoans attach to microbialite mounds which grow radially into free space shedding bioclasts in proportion to metazoan production . Models evolve mounds into columns due to spatial competition, and produce an oscillating interplay between mound expansion and smothering that results in an inter‐fingering of microbialite mound and detrital sediment. This dynamic is shown to be non‐linear in the proportion of bioclastic sediment produced. Smothering by bioclastic sediment is also demonstrated to both reduce the rate (by volume) of subsequent mound growth, and to overwhelm the growing mat surfaces of stromatolites: after a threshold is reached in the rate of bioclastic sediment deposition, sediment terminates all stromatolite growth. These models show that the general characteristics of field observations can be explained by a single dynamic rule, and that reef‐sourced bioclasts may make an important local contribution to Ediacaran to Cambrian microbial–metazoan reef dynamics – a contribution that remains important throughout the Phanerozoic.
Experimental Demonstration of an Impairment Aware Network Planning and Operation Tool for Transparent/Translucent Optical Networks (2010)

Core optical networks using reconfigurable optical switches and tunable lasers appear to be on the road towards widespread deployment and could evolve to all-optical mesh networks in the coming future. Considering the impact of physical layer impairments in the planning and operation of all-optical (and translucent) networks is the main focus of the Dynamic Impairment Constraint Optical Networking (DICONET) project. The impairment aware network planning and operation tool (NPOT) is the main outcome of DICONET project, which is explained in detail in this paper. The key building blocks of the NPOT, consisting of network description repositories, the physical layer performance evaluator, the impairment aware routing and wavelength assignment engines, the component placement modules, failure handling, and the integration of NPOT in the control plane are the main contributions of this study. Besides, the experimental result of DICONET proposal for centralized and distributed control plane integration schemes and the performance of the failure handling in terms of restoration time is presented in this study.
Charlson Comorbidity Index Is an Important Prognostic Factor for Long-Term Survival Outcomes in Korean Men with Prostate Cancer after Radical Prostatectomy (2014)

The CCI was independently associated with both OS and non-PCaSS after RP, but the CCI had no impact on PCaSS. The comorbidities of a patient should be considered before selecting RP as a curative modality for PCa.
Intranasal Immunization of Mice with a Bovine Respiratory Syncytial Virus Vaccine Induces Superior Immunity and Protection Compared to Those by Subcutaneous Delivery or Combinations of Intranasal and Subcutaneous Prime-Boost Strategies (2009)

Bovine respiratory syncytial virus (BRSV) infects cells of the respiratory mucosa, so it is desirable to develop a vaccination strategy that induces mucosal immunity. To achieve this, various delivery routes were compared for formalin-inactivated (FI) BRSV formulated with CpG oligodeoxynucleotide (ODN) and polyphosphazene (PP). Intranasal delivery of the FI-BRSV formulation was superior to subcutaneous delivery in terms of antibody, cell-mediated, and mucosal immune responses, as well as reduction in virus replication after BRSV challenge. Although intranasal delivery of FI-BRSV also induced higher serum and lung antibody titers and gamma interferon (IFN-gamma) production in the lungs than intranasal-subcutaneous and/or subcutaneous-intranasal prime-boost strategies, no significant differences were observed in cell-mediated immune responses or virus replication in the lungs of challenged mice. Interleukin 5 (IL-5), eotaxin, and eosinophilia were enhanced after BRSV challenge in the lungs of subcutaneously immunized mice compared to unvaccinated mice, but not in the lungs of mice immunized intranasally or through combinations of the intranasal and subcutaneous routes. These results suggest that two intranasal immunizations with FI-BRSV formulated with CpG ODN and PP are effective and safe as an approach to induce systemic and mucosal responses, as well to reduce virus replication after BRSV challenge. Furthermore, intranasal-subcutaneous and subcutaneous-intranasal prime-boost strategies were also safe and almost as efficacious. In addition to the implications for the development of a protective BRSV vaccine for cattle, formulation with CpG ODN and PP could also prove important in the development of a mucosal vaccine that induces protective immunity against human RSV.