gebhart/patrepeval huggingface dataset:
Interoperability Between Coastal Web Atlases Using Semantic Mediation: A Case Study of the International Coastal Atlas Network (ICAN) (2009)

Coastal mapping plays an important role in informing marine spatial planning, resource management, maritime safety, hazard assessment and even national sovereignty. As such, there is now a plethora of data/metadata catalogs, pre-made maps, tabular and text information on resource availability and exploitation, and decision-making tools. A recent trend has been to encapsulate these in a special class of web-enabled geographic information systems called a coastal web atlas (CWA). While multiple benefits are derived from tailor-made atlases, there is great value added from the integration of disparate CWAs. CWAs linked to one another can query more successfully to optimize planning and decision-making. If a dataset is missing in one atlas, it may be immediately located in another. Similar datasets in two atlases may be combined to enhance study in either region. But how best to achieve semantic interoperability to mitigate vague data queries, concepts or natural language semantics when retrieving and integrating data and information?&#13;\n&#13;\nWe report on the development of a new prototype seeking to interoperate between two initial CWAs: the Marine Irish Digital Atlas (MIDA) and the Oregon Coastal Atlas (OCA). These two mature atlases are used as a testbed for more regional connections, with the intent for the OCA to use lessons learned to develop a regional network of CWAs along the west coast, and for MIDA to do the same in building and strengthening atlas networks with the UK, Belgium, and other parts of Europe.&#13;\n&#13;\nOur prototype uses semantic interoperability via services harmonization and ontology mediation, allowing local atlases to use their own data structures, and vocabularies (ontologies). We use standard technologies such as OGC Web Map Services (WMS) for delivering maps, and OGC Catalogue Service for the Web (CSW) for delivering and querying ISO-19139 metadata. The metadata records of a given CWA use a given ontology of terms called local ontology. Human or machine users formulate their requests using a common ontology of metadata terms, called global ontology. A CSW mediator rewrites the user’s request into CSW requests over local CSWs using their own (local) ontologies, collects the results and sends them back to the user.&#13;\n&#13;\nTo extend the system, we have recently added global maritime boundaries and are also considering nearshore ocean observing system data. Ongoing work includes adding WFS, error management, and exception handling, enabling Smart Searches, and writing full documentation. This prototype is a central research project of the new International Coastal Atlas Network (ICAN), a group of 30+ organizations from 14 nations (and growing) dedicated to seeking interoperability approaches to CWAs in support of coastal zone management and the translation of coastal science to coastal decision-making.
Methylglyoxal-Induced Retinal Angiogenesis in Zebrafish Embryo: A Potential Animal Model of Neovascular Retinopathy (2019)

Methylglyoxal (MG) is an intermediate of glucose metabolism and the precursor of advanced glycation end products (AGEs) found in high levels in blood or tissue of diabetic patients. MG and AGEs are thought to play a major role in the pathogenesis of diabetic retinopathy. In order to determine if zebrafish is valuable to help us understand more about retinopathy, we evaluate if MG induces abnormal vascular change and angiogenesis in zebrafish in a short incubation period. We also used an inhibitor of VEGFR (PTK787) to explore the mechanistic role of VEGF in MG-induced pathogenesis. A transgenic <i>Tg(flk1:GFP)</i> zebrafish line was used, and the embryos were incubated with MG solution and in combination with glucose (to mimic hyperglycemia). Retinal vascular structure visible with fluorescence signal was imaged using fluorescence microscopy. The percentage of vascular area was calculated and found elevated in the MG treatment groups than that in the control group (<i>p</i> < 0.01) which indicated increased angiogenesis induced by MG treatment. PTK787 blocked the proangiogenic effects of MG treatment. This study suggests that MG has a potential proangiogenic effect via VEGF signaling in the retina of zebrafish embryos. Therefore, this zebrafish model may be used to study neovascular retinopathy.
Shortest Path versus Multi-Hub Routing in Networks with Uncertain Demand (2013)

We study a class of robust network design problems motivated by the need to scale core networks to meet increasingly dynamic capacity demands. Past work has focused on designing the network to support all hose matrices (all matrices not exceeding marginal bounds at the nodes). This model may be too conservative if additional information on traffic patterns is available. Another extreme is the fixed demand model, where one designs the network to support peak point-to-point demands. We introduce a capped hose model to explore a broader range of traffic matrices which includes the above two as special cases. It is known that optimal designs for the hose model are always determined by single-hub routing, and for the fixed- demand model are based on shortest-path routing. We shed light on the wider space of capped hose matrices in order to see which traffic models are more shortest path-like as opposed to hub-like. To address the space in between, we use hierarchical multi-hub routing templates, a generalization of hub and tree routing. In particular, we show that by adding peak capacities into the hose model, the single-hub tree-routing template is no longer cost-effective. This initiates the study of a class of robust network design (RND) problems restricted to these templates. Our empirical analysis is based on a heuristic for this new hierarchical RND problem. We also propose that it is possible to define a routing indicator that accounts for the strengths of the marginals and peak demands and use this information to choose the appropriate routing template. We benchmark our approach against other well-known routing templates, using representative carrier networks and a variety of different capped hose traffic demands, parameterized by the relative importance of their marginals as opposed to their point-to-point peak demands.
A Sensitive Chemotaxis Assay Using a Novel Microfluidic Device (2013)

Existing chemotaxis assays do not generate stable chemotactic gradients and thus--over time--functionally measure only nonspecific random motion (chemokinesis). In comparison, microfluidic technology has the capacity to generate a tightly controlled microenvironment that can be stably maintained for extended periods of time and is, therefore, amenable to adaptation for assaying chemotaxis. We describe here a novel microfluidic device for sensitive assay of cellular migration and show its application for evaluating the chemotaxis of smooth muscle cells in a chemokine gradient.
THE ELECTRONIC STRUCTURES AND REACTIVITIES OF Mn(CO)5X COMPLEXES (1963)

The bonding in Mn(CO) 5 X complexes is described in terms of molecular orbitals. The axial CO group is assumed to be bonded much more strongly to Mn than the other four CO groups. The molecular orbital energy level scheme thus derived successfully accounts for the principal features of the electronic spectra of Mn(CO) 5 X complexes in different solvents. The first charge transfer band is assigned as an n(Mn) → π*(CO) type transition. This n → π* assignment is supported by the fact that the maximum of the band for Mn(CO) 5 Br is shifted to higher energies on increasing the polarity of the solvents employed.Kinetic studies of Mn(CO) 5 X- 14 CO exchange reveal that the axial CO is more inert than the other four CO groups; also, the rates of 14 CO exchange of the four equivalent CO groups in Mn(CO) 5 X complexes depend strikingly on the nature of the X − ligand. A consistent interpretation of the above results and the observed kinetics of some typical substitution reactions of Mn(CO) 5 X complexes is presented in terms of the derived electronic structural description.
Power minimization in DSP application specific systems using algorithm selection (2002)

We introduce the algorithm selection problem for power minimization. After demonstrating the high impact of this synthesis task on the power consumption of the final implementation using a case study, we studied its computational complexity. We present an efficient optimization intensive algorithm for power minimization using algorithm selection. We applied the marginal utility-based algorithm for algorithm selection on three DSP examples. A table illustrates the effectiveness of the power optimization using algorithm selection on one audio (LMS DCT transform domain filter) and two video (NTSC formatter and DPCM coder) applications. On several DSP examples more than an order of magnitude reduction in power is demonstrated.
Some important properties and inequalities of the Riemannian Fisher Information Distance. (2015)

&lt;p&gt;Some important properties and inequalities of the Riemannian Fisher Information Distance.&lt;/p&gt;
Effective Rate Evaluation of RIS-Assisted Communications Using the Sums of Cascaded α-μ Random Variates (2021)

This paper begins with the characterization of the sum of M versions of cascaded α-μ (equivalently, N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">*</sub> (α-μ)) distributed random variates (RVs), and later on, explores the feasibility and applicability of the obtained results in the recent proposed reconfigurable intelligent surface (RIS)-assisted communications. More specifically, the sum of cascaded α-μ distributed RVs is exactly characterized by the probability density function (PDF) expressed in terms of the programmable multivariate Fox's H-function, and approximated with the mixture of Gaussian (MoG) distribution. The approximation accuracy is further validated by the Kolmogorov-Smirnov (KS) goodness of fit test. Based on the obtained statistical results, a promising application, i.e., RIS-assisted communication, is considered and evaluated from the effective rate perspective. The exact, asymptotic, and approximated effective rate are derived with closed-form expressions. Finally, our analytical results are further validated using the Monte-Carlo simulation, their accuracy is confirmed with the analytical error indicator. One can conclude that (i) the exact effective rate expression is complex in the manner of mathematical representation; (ii) the MoG-based effective rate expression is simple and provides a highly tight approximation to the exact expression, besides it indeed acts as a highly tight upper bound for the exact effective rate expression; and (iii) the MoG-based solution outperforms the multivariate Fox's H-function based approach with reducing complexity.
Lightguiding in Photochromic Glasses (1975)

Lightguiding in ion-exchanged photochromic glass layers is reported. The guides were formed by ion exchange of Ag(+) for Na(+) or by outdiffusion of F. Guide attenuation was less than 0.2 dB/cm in many cases. The attenuation in the guide was varied over a range of Deltaalpha = 30 dB/cm by illuminating the guide with (1) uv radiation to darken the guide or order of seconds. (2) visible radiation to bleach the guide. Switching times were in the order of seconds.
Staying the Course (2016)

The negative effect of lapses during a behavior-change program has been shown to increase the risk of repeated lapses and, ultimately, program abandonment. In this paper, we examine the potential of system-driven lapse management -- supporting users through lapses as part of a behavior-change tool. We first review lessons from domains such as dieting and addiction research and discuss the design space of lapse management. We then explore the value of one approach to lapse management -- the use of "cheat points" -- as a way to encourage sustained participation. In an online study, we first examine interpretations of progress that was reached through using cheat points. We then present findings from a deployment of lapse management in a two-week field study with 30 participants. Our results demonstrate the potential of this approach to motivate and change users' behavior. We discuss important open questions for the design of future technology-mediated behavior change programs.
An Increased Intraovarian Synthesis of Nerve Growth Factor and Its Low Affinity Receptor Is a Principal Component of Steroid-Induced Polycystic Ovary in the Rat1 (2000)

A form of polycystic ovary (PCO) resembling some aspects of the human PCO syndrome can be induced in rats by a single injection of estradiol valerate (EV). An increase in sympathetic outflow to the ovary precedes, by several weeks, the appearance of cysts, suggesting the involvement of a neurogenic component in the pathology of this ovarian dysfunction. The present study was carried out to test the hypotheses that this change in sympathetic tone is related to an augmented production of ovarian nerve growth factor (NGF), and that this abnormally elevated production of NGF contributes to the formation of ovarian cysts induced by EV. Injection of the steroid resulted in increased intraovarian synthesis of NGF and its low affinity receptor, p75 NGFR. The increase was maximal 30 days after EV, coinciding with the elevation in sympathetic tone to the ovary and preceding the appearance of follicular cysts. Intraovarian injections of the retrograde tracer fluorogold combined with in situ hybridization to detect tyrosine hydroxylase (TH) messenger RNA-containing neurons in the celiac ganglion revealed that these changes in NGF/p75 NGFR synthesis are accompanied by selective activation of noradrenergic neurons projecting to the ovary. The levels of RBT2 messenger RNA, which encodes a beta-tubulin presumably involved in slow axonal transport, were markedly elevated, indicating that EV-induced formation of ovarian cysts is preceded by functional activation ofceliac ganglion neurons, including those innervating the ovary. Intraovarian administration of a neutralizing antiserum to NGF in conjunction with an antisense oligodeoxynucleotide to p75 NGFR, via Alzet osmotic minipumps, restored estrous cyclicity and ovulatory capacity in a majority of EV-treated rats. These functional changes were accompanied by restoration of the number of antral follicles per ovary that had been depleted by EV and a significant reduction in the number of both precystic follicles and follicular cysts. The results indicate that the hyperactivation of ovarian sympathetic nerves seen in EV-induced PCO is related to an overproduction of NGF and its low affinity receptor in the gland. They also suggest that activation of this neurotrophic-neurogenic regulatory loop is a component of the pathological process by which EV induces cyst formation and anovulation in rodents. The possibility exists that a similar alteration in neurotrophic input to the ovary contributes to the etiology and/or maintenance of the PCO syndrome in humans.
Active Interrogation Using Electronic Neutron Generators for Nuclear Safeguards Applications (2009)

Active interrogation, a measurement technique which uses a radiation source to probe materials and generate unique signatures useful for characterizing those materials, is a powerful tool for assaying special nuclear material. The most commonly used technique for performing active interrogation is to use an electronic neutron generator as the probe radiation source. Exploiting the unique operating characteristics of these devices, including their monoenergetic neutron emissions and their ability to operate in pulsed modes, presents a number of options for performing prompt and delayed signature analyses using both photon and neutron sensors. A review of literature in this area shows multiple applications of the active neutron interrogation technique for performing nuclear nonproliferation measurements. Some examples include measuring the plutonium content of spent fuel, assaying plutonium residue in spent fuel hull claddings, assaying plutonium in aqueous fuel reprocessing process streams, and assaying nuclear fuel reprocessing facility waste streams to detect and quantify fissile material. This paper discusses the historical use of this technique and examines its context within the scope and challenges of next‐generation nuclear fuel cycles and advanced concept nuclear fuel cycle facilities.
Accelerators for biologically-inspired attention and recognition (2013)

Video and image content has begun to play a growing role in many applications, ranging from video games to autonomous self-driving vehicles. In this paper, we present accelerators for gist-based scene recognition, saliency-based attention, and HMAX-based object recognition that have multiple uses and are based on the current understanding of the vision systems found in the visual cortex of the mammalian brain. By integrating them into a two-level hierarchical system, we improve recognition accuracy and reduce computational time. Results of our accelerator prototype on a multi-FPGA system show real-time performance and high recognition accuracy with large speedups over existing CPU, GPU and FPGA implementations.
An Efficient Multi-Beam Pattern Measurement Campaign for Millimeter-Wave Phased Arrays (2023)

The performance of millimeter-wave (mmWave) radio systems depends on accurate knowledge of mmWave phased array multi-beam patterns. However, the conventional antenna pattern measurement methods are inefficient for mmWave multi-beam measurements. To solve the problem, a fast multi-beam reconstruction method has been proposed in the literature. Based on that, this paper conducts an efficient multi-beam pattern measurement campaign for a practical 4 × 4 mmWave phased array antenna-in-package (AiP). The measurement results show that the element patterns of an active phased array AiP measured in the on-off and all-on modes might differ, especially for large-scale arrays. Furthermore, the reconstructed array multi-beam patterns by the proposed method are compared with the conventional compact antenna testing range (CATR) measurement data. The all-on reconstructed array multi-beam patterns matches better with the target array patterns than the on-off reconstructed array patterns.
Self-assembly of carbon black into nanowires that form a conductive three dimensional micronetwork (2007)

The authors have used mechanical self-assembly of carbon-black nanoparticles to fabricate a three dimensional, electrically connected micronetwork of nanowires embedded within an insulating, supporting matrix of poly(methyl methacrylate). The electrical connectivity, mean wire diameter, and morphological transitions were characterized as a function of the carbon-black mass fraction. Conductive wires were produced with mean diameters as low as 24nm with lengths up to 100μm.
Polypeptide Polymer Brushes by Light‐Induced Surface Polymerization of Amino Acid N‐Carboxyanhydrides (2018)

Silicon wafers are decorated with photoamine generator 4,5-dimethoxy-2-nitrobenzyl 3-(triethoxysilyl)propyl carbamate. UV-irradiation in the presence of benzyl-l-glutamate N-carboxyanhydride is carried out, resulting in the release of the surface-bound primary amines, making them viable N-carboxyanhydride (NCA) polymerization initiators. Successful polypeptide grafting is confirmed by water contact angle measurements as well as by ellipsometry, revealing a poly(benzyl-l-glutamate) (PBLG) layer of ≈3 nm. X-ray photoelectron spectroscopy confirms the presence of amide groups in the grafted PBLG while time-of-flight secondary ion mass spectroscopy provides additional evidence for the presence of PBLG on the surface. Evaluation of negative control samples confirms successful UV surface grafting. The approach is thus established as a viable general method for light exposure directable polypeptide functionalization of silicon surfaces.
L5-S1 SURVIVAL AFTER INTERBODY FUSION BY LATERAL APPROACH UNTIL L5 IN DEGENERATIVE DISEASE (2019)

ABSTRACT Objectives: Whether or not to include L5-S1 in multiple level lumbar fusions is not yet a consensus in the literature. The option to preserve L5-S1 maintains the mobile segment and the possibility of a natural fit to the sagittal alignment of the lumbar spine. However, a long fusion above L5-S1 may accelerate the degenerative process and an extension to the sacrum may be necessary in the future. In this study, we evaluated the survival of the L5-S1 level after lateral lumbar interbody fusion (LLIF) of 3-4 levels up to L5 and attempted to identify risk factors that could guide the selection of cases. Methods: Retrospective study in a single center. Inclusion: Patients that submitted to interbody fusion (LLIF) from 3-4 levels to L5 due to degenerative spine disease with at least 5 years of follow-up. Exclusion: L5 sacralization or L5-S1 disc ankylosis. We evaluated the reoperation rate including L5-S1 disc. We reviewed the preoperative images regarding coronal Cobb angle, lumbar lordosis, pelvic incidence; distal fractional curve; radiographic classification of DDD (modified by Weiner and Pfirrmann), as well as demographics parameters. These parameters were compared between the case group (reoperated) and the control group. Results: Forty-seven patients were included achieving a success rate of inclusion of 81%; the mean age was 69.1 years, 83% were women, and the mean of operated levels was 3.2. The survival rate of L5-S1 level was 89.6% at 5-year follow-up. No differences were found between the groups regarding the parameter evaluated. Conclusions: The L5-S1 survival rate was 896% after LLIF of 3-4 levels up to L5 at 5-year follow-up. Statistically no risk factors were found to warrant preoperative inclusion of L5-S1. Level of Evidence III; Retrospective Study.
Characterization of a conserved T cell epitope in HIV-1 gp41 recognized by vaccine-induced human cytolytic T cells (1991)

A human CTL epitope located in a region of the HIV-1 envelope protein gp41 that is highly conserved among various HIV-1 strains was identified. This epitope was recognized by CD4+ CTL clones that were induced in seronegative humans by immunization with recombinant gp160. Fusion proteins carrying portions of the HIV-1 env gene and synthetic peptides were used to localize this epitope to amino acids 584-595 of the HIV-1 BRU env sequence. Only two positions within this epitope showed variation among North American HIV-1 isolates, and the substitutions were conservative in nature. The Lys to Arg substitution at position 593 abolished recognition, probably by interfering with the peptide-MHC interactions. This epitope was recognized in association with at least one subtype of the widely distributed human class II MHC specificity DPw4, namely DPw4.2. The relatively high frequency of this allele (27.2% among Caucasians) makes it likely that a larger fraction of the population would generate a response directed at this epitope than would be the case for epitopes recognized in the context of gene products of most other class II and class I loci. Interestingly, the closely related DP beta-chain allele types 4.1 and 2.1, which differ from 4.2 by 3 and 1 amino acids, respectively, were unable to present this gp41 peptide to DPw4.2-restricted clones. Comparison of the structure of this epitope with that of other peptides recognized in the context of DPw4.2 led to the identification of a consensus sequence for DPw4.2 binding peptides. Because the gp41 CTL epitope 584-595 identified here is highly conserved and is recognized in the context of a common DP allele, it may represent an important target region for vaccine development. Our results indicate that vaccines containing this epitope may induce in a significant fraction of those immunized CTL active against at least half of all HIV-1 strains.