gebhart/patrepeval huggingface dataset:
886: Chemosensitization of Gemcitabine-Resistant Human Bladder Cancer Cell Line both in vitro and in vivo Using Antisense Oligonucleotides Targetting the Anti-Apoptotic Gene, Clusterin (2007)

You have accessJournal of UrologyModerated Poster 25, Monday, May 21, 2007, 1:00 - 3:00 pm1 Apr 2007886: Chemosensitization of Gemcitabine-Resistant Human Bladder Cancer Cell Line both in vitro and in vivo Using Antisense Oligonucleotides Targetting the Anti-Apoptotic Gene, Clusterin Mototsugu Muramaki, Hideaki Miyake, Masato Fujisawa, and Martin E. Gleave Mototsugu MuramakiMototsugu Muramaki More articles by this author , Hideaki MiyakeHideaki Miyake More articles by this author , Masato FujisawaMasato Fujisawa More articles by this author , and Martin E. GleaveMartin E. Gleave More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)31114-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "886: Chemosensitization of Gemcitabine-Resistant Human Bladder Cancer Cell Line both in vitro and in vivo Using Antisense Oligonucleotides Targetting the Anti-Apoptotic Gene, Clusterin." The Journal of Urology, 177(4S), pp. 294–295 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 294-295 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Mototsugu Muramaki More articles by this author Hideaki Miyake More articles by this author Masato Fujisawa More articles by this author Martin E. Gleave More articles by this author Expand All Advertisement PDF downloadLoading ...
Write position shifts in heat-assisted magnetic recording (2017)

Micromagnetic simulations have been performed to investigate the write position shifts in heat-assisted magnetic recording (HAMR) under variation of variables including the thermal profile, write field magnitude, head velocity, media damping, and write field rise time. Simulations reveal that a larger head velocity or a larger media damping tends to shift the write positions towards the heat center. Simulation results are also compared to the predictions of an analytical model based on classical mean-field theory. It is found that, with smaller thermal gradients the analytical model tends to give write positions closer to the heat center; whereas when thermal gradients are larger it tends to shift the write positions away from the heat center. All these effects appear to be dynamic, and can be understood by recognizing the lag between spin temperature and lattice temperature that cannot be captured by the analytical model that assumes equilibrium at all times.
Inverted organic photosensitive devices (2023)

The present disclosure relates to organic photosensitive optoelectronic devices grown in an inverted manner. An inverted organic photosensitive optoelectronic device of the present disclosure comprises a reflective electrode, an organic donor-acceptor heterojunction over the reflective electrode, and a transparent electrode on top of the donor-acceptor heterojunction.
Evaluation Of Patients With Early Repolarization Syndrome. (2014)

In recent years, the early repolarization pattern has emerged as a risk factor for malignant ventricular arrhythmias and sudden cardiac death. The identification of the subset of patients who are at high risk of sudden death represents a significant challenge to the clinician. Multiple clinical and ECG features have been associated with an increased risk of sudden deathin however the majority of risk factors confer a small increase in absolute risk. The present article reviews current evidence and potential management strategies in patients with early repolarization.
<title>Three-dimensional morphology of LCPC using confocal fluorescence microscopy</title> (1998)

We have developed a new method for characterizing morphology of LCPC based on confocal fluorescence microscopy. Not only two-dimensional but also three-dimensional morphology of LCPC can be observed nondestructively by this method. The morphology of LCPC was consisted of liquid crystal and polymer phases, both of which are three-dimensionally continuous. Quantitative analysis of morphology was also made to clarify the relation between morphology and electro-optical characteristics. The local size of structure was obtained quantitatively from the perimeter of liquid crystal and polymer. It was found that the change in the value matched well with the change in morphology and it was related with the electro-optical characteristics.
Phase transition behavior of (K,Na)NbO3-based high-performance lead-free piezoelectric ceramic composite with different phase compositions depending on Na fraction (2017)

The structures of the main (K1−xNax)NbO3 perovskite in a high-performance lead-free piezoelectric ceramic composite (K1−xNax)0.86Ca0.04Li0.02Nb0.85O3−δ–K0.85Ti0.85Nb1.15O5–BaZrO3–MgO–Fe2O3 (x = 0.52 and 0.70) with trace amounts of LiMgFeTiO4 inverse spinel and (Li,K)2(Mg,Fe,Ti,Nb)6O13 layered structure have been investigated by transmission electron microscopy (TEM) and synchrotron powder X-ray diffractometry (XRD) with varying temperatures. The bright-field TEM images have shown tetragonal 90°-domain contrasts at 80 and 40 °C, and the XRD profile has been simulated by adding an average structure of two differently oriented tetragonal structures bound by a 90°-domain wall for the x = 0.52 sample. Aggregates of tilted NbO6 nanodomains have been observed in a high-resolution TEM image, and the crossover of P4mm–Amm2 features from 60 to 20 °C and diffuse 2 × 2 × 2 superlattice reflections of the tilted NbO6 Imm2 structure have been observed in XRD data for the x = 0.70 sample.
Implementation of Cerebral Autoregulation Into Computational Fluid Dynamics Studies of Cardiopulmonary Bypass (2012)

Peri- or postoperative neurological complications are among the main risks for patients undergoing extracorporeal circulatory support (ECC). Two of the main reasons are an increased risk for strokes and altered flow conditions leading to cerebral hypoperfusion. This is strongly affected by cerebral autoregulation, which is the body's intrinsic ability to provide sufficient cerebral blood flow (CBF) despite changes in cerebral perfusion pressure (CPP). This complex mechanism has been mainly neglected in numerical studies, which have often been applied for analysis of ECC. In this study, a mathematical model is presented to implement cerebral autoregulation into computational fluid dynamics (CFD) studies. CFD simulations of cardiopulmonary bypass (CPB) were performed in a 3D model of the cardiovascular system, with flow variations between 4.5-6 L/min. Cerebral outlets were modeled using an equation to calculate CBF based on CPP. Assuming full regulation, CBF was kept constant for CPP between 80 and 120 mm Hg. A deviation in CBF of 20% occurred for CPP between 55-80 mm Hg and 120-145 mm Hg, respectively. The level of regulation was varied to take possible impairment of cerebral autoregulation into account. Furthermore, chronic hypertension was modeled by increasing the baseline CPP. Results indicate that even for full autoregulation, CBF is decreased during CPB. It is even lower for impaired autoregulation and hypertensive patients, demonstrating the strong impact of autoregulation on CBF. It is therefore imperative to include this mechanism into CFD studies. The presented model can help to improve CPB support conditions based on patient-specific autoregulation parameters.
Ambulatory Monitoring of Heart Sounds via an Implanted Device Is Superior to Auscultation for Prediction of Heart Failure Events (2019)

S3 measured by implantable cardiac devices has stronger prognostic power to predict episodes of future HFEs than that of auscultation.
Supplementary Materials and Methods from Chemogenetic Evaluation of the Mitotic Kinesin CENP-E Reveals a Critical Role in Triple-Negative Breast Cancer (2023)

&lt;p&gt;PDF - 238K, Supplementary Materials and Methods&lt;/p&gt;
Strong Inverse Correlation Between MicroRNA-125b and Human Papillomavirus DNA in Productive Infection (2010)

Infection by the human papillomavirus (HPV) is a cause of cervical intraepithelial neoplasia (CIN) and cancer. microRNA (miRNA) in situ analysis of the transformation zone epithelia, the site of initial cervical HPV infection, showed that miRNAs let-7c, -99a, 26a, and 125b were the most abundantly expressed. In situ testing of CIN 1 showed a dramatic reduction in miR-125b expression in the koilocytes, the cytologic marker of productive HPV infection. A marked reduction in miR-125b was likewise observed in the HPV-infected cells of the condyloma acuminatum, verruca vulgaris, and epidermodysplasia verruciformis. Reverse transcriptase in situ polymerase chain reaction (PCR) showed that the pre-miRNA 125b was present in the koilocyte, suggesting direct inactivation of the mature miRNA. HEK cells transfected with only the antimiR-125b showed perinuclear halos equivalent to HPV-infected koilocytes. NIH 3T3 cells transfected with the HPV 16 full-length genome and mimetic miR-125b showed a marked reduction in viral DNA and protein synthesis by quantitative PCR and in situ-based analyses, respectively (P=0.002). Alternatively, cotransfection with anti-miR-125b and HPV 16 markedly increased HPV DNA (P=0.002). Sequence analyses showed strong homology between L2 of different HPV genotypes and miR-125b. Transfection with HPV 16 L2 resulted in a marked reduction in miR-125b levels in the NIH 3T3 cells. HPV L2-induced inactivation of miR-125b is associated with the classic cytologic changes of the koilocyte, and the exogenous application of mimetic miR-125b markedly inhibits HPV DNA synthesis.
Mobility for heterogeneous SmallNets (2012)

In this paper we consider mobility in a network of converged small-cell gateways, each capable of aggregating cellular and unlicensed bandwidth by combining a WiFi AP and a cellular base station within a single-box. A network of such gateways must provide mobility services in a decentralized fashion and we demonstrate how this may be accomplished by taking advantage of Proxy Mobile IPv6 (PMIP) - the network-based version of the Mobile IP protocol. We also describe how the placement of the single-box allows for an improved user experience, increasing throughput and maintaining IP Flows when either the cellular or WiFi connections degrade.
MAUI (2010)

This paper presents MAUI, a system that enables fine-grained energy-aware offload of mobile code to the infrastructure. Previous approaches to these problems either relied heavily on programmer support to partition an application, or they were coarse-grained requiring full process (or full VM) migration. MAUI uses the benefits of a managed code environment to offer the best of both worlds: it supports fine-grained code offload to maximize energy savings with minimal burden on the programmer. MAUI decides at run-time which methods should be remotely executed, driven by an optimization engine that achieves the best energy savings possible under the mobile device's current connectivity constrains. In our evaluation, we show that MAUI enables: 1) a resource-intensive face recognition application that consumes an order of magnitude less energy, 2) a latency-sensitive arcade game application that doubles its refresh rate, and 3) a voice-based language translation application that bypasses the limitations of the smartphone environment by executing unsupported components remotely.
Direct multiplex assay of enzymes in dried blood spots by tandem mass spectrometry for the newborn screening of lysosomal storage disorders (2006)

Tandem mass spectrometry is currently used in newborn screening programmes to quantify the level of amino acids and acylcarnitines in dried blood spots for detection of metabolites associated with treatable diseases. We have developed assays for lysosomal enzymes in rehydrated dried blood spots in which a set of substrates is added and the set of corresponding enzymatic products are quantified using tandem mass spectrometry with the aid of mass-differentiated internal standards. We have developed a multiplex assay of the set of enzymes that, when deficient, cause the lysosomal storage disorders Fabry, Gaucher, Hurler, Krabbe, Niemann-Pick A/B and Pompe diseases. These diseases were selected because treatments are now available or expected to emerge shortly. The discovery that acarbose is a selective inhibitor of maltase glucoamylase allows the Pompe disease enzyme, acid alpha-glucosidase, to be selectively assayed in white blood cells and dried blood spots. When tested with dried blood spots from 40 unaffected individuals and 10-12 individuals with the lysosomal storage disorder, the tandem mass spectrometry assay led to the correct identification of the affected individuals with 100% sensitivity. Many of the reagents needed for the new assays are commercially available, and those that are not are being prepared under Good Manufacturing Procedures for approval by the FDA. Our newborn screening assay for Krabbe disease is currently being put in place at the Wadsworth Center in New York State for the analysis of approximately 1000 dried blood spots per day. Summary We have developed tandem mass spectrometry for the direct assay of lysosomal enzymes in rehydrated dried blood spots that can be implemented for newborn screening of lysosomal storage disorders. Several enzymes can be analysed by a single method (multiplex analysis) and in a high-throughput manner appropriate for newborn screening laboratories.
MapQuant: Open‐source software for large‐scale protein quantification (2006)

Whole-cell protein quantification using MS has proven to be a challenging task. Detection efficiency varies significantly from peptide to peptide, molecular identities are not evident a priori, and peptides are dispersed unevenly throughout the multidimensional data space. To overcome these challenges we developed an open-source software package, MapQuant, to quantify comprehensively organic species detected in large MS datasets. MapQuant treats an LC/MS experiment as an image and utilizes standard image processing techniques to perform noise filtering, watershed segmentation, peak finding, peak fitting, peak clustering, charge-state determination and carbon-content estimation. MapQuant reports abundance values that respond linearly with the amount of sample analyzed on both low- and high-resolution instruments (over a 1000-fold dynamic range). Background noise added to a sample, either as a medium-complexity peptide mixture or as a high-complexity trypsinized proteome, exerts negligible effects on the abundance values reported by MapQuant and with coefficients of variance comparable to other methods. Finally, MapQuant's ability to define accurate mass and retention time features of isotopic clusters on a high-resolution mass spectrometer can increase protein sequence coverage by assigning sequence identities to observed isotopic clusters without corresponding MS/MS data.
Sinusoidal reluctance machine with DC winding: An attractive non-permanent magnet option (2015)

Important global efforts are underway toward lowering the cost of electric machines for electric and hybrid vehicles by reducing or eliminating the use of rare earth materials which have been experiencing significant price increases and volatility. Non-permanent magnet electric machines are a potential solution and are increasingly investigated by researchers worldwide. This paper presents a DC biased reluctance machine which is structurally similar to a conventional switched reluctance machine. This type of machine has a DC field winding and an AC three phase armature winding. It uses a conventional three phase inverter for the armature and an additional auxiliary DC/DC converter for the field winding. This reluctance machine is designed to achieve hybrid vehicle traction requirements of 55kW peak at 2800 rpm and 30kW continuous over a speed range going from 2800 rpm to 14000 rpm.
Complexes of oxygen and native defects in GaAs (1992)

Series of isochronal high-temperature (1000--1225 \ifmmode^\circ\else\textdegree\fi{}C) annealing experiments followed by quenching have been performed on GaAs crystals doped with oxygen. The defect concentrations and atomic structures have been monitored by localized vibrational mode (LVM) spectroscopy. Besides well-known isolated interstitial oxygen and a complex of oxygen interstitial and arsenic vacancy, three additional centers have been observed. Based on their annealing behavior and analysis of the LVM fine structure, these additional defects have been interpreted as complexes of interstitial oxygen and thermally generated divacancies. A tentative model for each center has been proposed.
Hierarchical classification of modulation signals (2003)

This paper addresses the problem of classifying both analog and digital modulation signals. A total of 31 features were used to classify 11 modulation signals plus white noise in a hierarchical fashion. The modulation signals included carrier wave (CW), AM, FM, SSB, FSK2, FSK4, PSK2, PSK4, OOK, QAM16, and QAM32. Genetic algorithm was used to obtain the most effective set of features at each level of the hierarchy. Based on the selected features at each level, a Bayes classifier was then designed to separate the most distinct subclasses at that level. The obtained classification results indicate the effectiveness of the introduced hierarchical classification.
V 2 O 3 ‐Polymer Composite Thermistors (1987)

V 2 O 3 was incorporated into polymer matrices to produce composite materials with low room‐temperature resistivities and sizable positive temperature coefficient (PTC) resistance effects. In addition, a negative temperature coefficient effect, associated with the semiconductor‐to‐metal phase transition in V 2 O 3 , was also observed. The resistivity vs temperature curve for these composites resembles a square well with three temperature regimes in which the composite behaves like a semiconductor, a metal, and an insulator. The intensity of the PTC effect for these composites was found to be as large as 10 orders of magnitude.
Kinematic Changes After Fusion and Total Replacement of the Ankle Part 3: Talar Movement (2003)

The two-component ankle (AGILITY) obviously tends to restrict tremendously talar motion within the ankle mortise, whereas the three-component ankles (HINTEGRA, S.T.A.R.) seem to allow talar range of motion comparable to that in the normal ankle. It is suggested that such a restriction of talar motion results in an increase of stress forces within and around the prosthesis, leading to polyethylene wear and potential loosening at the bone-implant interfaces. Therefore, a successful prosthetic design for the ankle should consist of three components that are shaped as anatomically as possible to provide a normal range of motion and to allow the full transmission of movement transfer between foot and shank and unconstrained movement of the talus within the ankle mortise.
Quantification of Protein Kinase Enzymatic Activity in Unfractionated Cell Lysates Using CSox‐Based Sensors (2014)

Defining perturbations in protein kinase activity within biological samples can provide insight into disease mechanisms as well as potential targets for drug development. In this article, we present a method that utilizes a phosphorylation-sensitive amino acid, termed CSox, to afford kinase-selective biosensors capable of reporting on enzymatic activity directly in biological samples. These sensors produce an increase in fluorescence in response to phosphorylation of an amino acid residue adjacent to CSox. Probes can be designed for either serine/threonine or tyrosine kinases, and analysis can be performed using standard fluorescence equipment. The procedures provided herein represent our optimized protocols for the design, validation, and application of CSox-based protein kinase activity sensors.
Mus spretus LINE-1 sequences detected in the Mus musculus inbred strain C57BL/6J using LINE-1 DNA probes. (1995)

The inbred mouse strain, C57BL/6J, was derived from mice of the Mus musculus complex. C57BL/6J can be crossed in the laboratory with a closely related mouse species, M. spretus to produce fertile offspring; however there has been no previous evidence of gene flow between M. spretus and M. musculus in nature. Analysis of the repetitive sequence LINE-1, using both direct sequence analysis and genomic Southern blot hybridization to species-specific LINE-1 hybridization probes, demonstrates the presence of LINE-1 elements in C57BL/6J that were derived from the species M. spretus. These spretus-like LINE-1 elements in C57BL/6J reveal a cross to M. spretus somewhere in the history of C57BL/6J. It is unclear if the spretus-like LINE-1 elements are still embedded in flanking DNA derived from M. spretus or if they have transposed to new sites. The number of spretus-like elements detected suggests a maximum of 6.5% of the C57BL/6J genome may be derived from M. spretus.
Supp. Table S22 from Genetic Mechanisms of Immune Evasion in Colorectal Cancer (2023)

&lt;p&gt;Supplementary Table S22: Segmented b-allele deficits&lt;/p&gt;
Power-efficient mobile backhaul design for CoMP support in future wireless access systems (2011)

Base Stations (BSs) cooperation techniques, also referred to as Coordinated Multi-Point (CoMP) in the 3GPP terminology, promise significant performance gains in future 4G and beyond systems. The counterpart to such gains is represented by the challenging requirements that CoMP puts on the backhaul network, which may prevent the inclusion of certain BSs selected for the cooperative cluster. The consequences of such a failure can be relevant for the overall power consumption. Those BSs which are not eligible for cooperation would be unnecessarily included in the channel estimation process, which consumes power both at the BS side (sending of reference pilots) and on the backhaul network side (exchange of Channel State Information (CSI) between BSs). To limit the detrimental effects of such CoMP cluster “unfeasibility”, we discuss the benefits of a cross-layer approach which relates wireless CoMP requests to the backhaul network status. We show how the preemptive exclusion of the non-eligible BSs results in a considerable saving of the overall power consumption. We further complement our system by proposing optical bypass techniques aimed at improving the CoMP support from the backhaul perspective. This results, on one side, in the enhancement of the overall CoMP feasibility performance, and, on the other side, in the reduction of the consumed power thanks to the offload of IP processing to the switching layer1.