gebhart/patrepeval huggingface dataset:
Broadband Bent Triangular Omnidirectional Antenna for RF Energy Harvesting (2015)

In this letter, a broadband bent triangular omnidirectional antenna is presented for RF energy harvesting. The antenna has a bandwidth for VSWR ≤ 2 from 850 MHz to 1.94 GHz. The antenna is designed to receive both horizontal and vertical polarized waves and has a stable radiation pattern over the entire bandwidth. Antenna has also been optimized for energy harvesting application and it is designed for 100 Ω input impedance to provide a passive voltage amplification and impedance matching to the rectifier. A peak efficiency of 60% and 17% is obtained for a load of 500 Ω at 980 and 1800 MHz, respectively. At a cell site while harvesting all bands simultaneously a voltage of 3.76 V for open circuit and 1.38 V across a load of 4.3 k Ω is obtained at a distance of 25 m using an array of two elements of the rectenna.
An examination of trends in antibiotic prescribing by area-level deprivation in England (2020)

Abstract Background As part of an approach to reduce antimicrobial resistance, there has been strategic focus placed on reducing antibiotic prescribing. Given these policy drivers, there is a pressing need to understand the nature of antibiotic prescribing by primary care, and to understand how this changes by socioeconomic deprivation, when controlling for confounding variables. This is crucial in order to inform future antibiotic prescribing targets to ensure such targets do not impact on people with the most health need and thus potentially widen health inequalities.Methods Antibiotic prescribing data for the years 2014-2018 were matched with the Index of Multiple Deprivation (IMD 2015) deciles and graphically presented to explore trends over time. Multi-level analysis on antibiotic use was used to assess the impact of deprivation alongside a range of other confounding variables, including health need, geographic region and GP quality rating.Results Our study highlighted three key results: (1) GP surgeries located in the most deprived areas had the highest levels of antibiotic prescribing (adjusting for health need accounted for most of this variation); (2) there was inequalities in the prescribing of broad spectrum antibiotics according to deprivation; (3) there was significant geographical variation in antibiotic prescribing.Conclusion Future antibiotic prescribing targets should account for deprivation and/or health need to ensure GP practices located in the most deprived communities are not inappropriately penalised.
A Methodological Analysis of the Plastic Surgery Cost-Utility Literature Using Established Guidelines (2014)

The identified studies manifest the potential of cost-utility analyses in plastic surgery. Nonetheless, they are inconsistent in applying established cost-utility guidelines, especially in measuring costs and conducting recommended sensitivity analysis. Following this simple scoring tool can help future studies achieve some necessary improvements.
The Australasian dingo archetype: de novo chromosome-length genome assembly, DNA methylome, and cranial morphology (2023)

These combined data support the hypothesis that the dingo Cooinda fits the spectrum of genetic and morphologic characteristics typical of the Alpine ecotype. We propose that she be considered the archetype specimen for future research investigating the evolutionary history, morphology, physiology, and ecology of dingoes. The female has been taxidermically prepared and is now at the Australian Museum, Sydney.
Effect of captopril on the release of the components of the renin-angiotensin system into plasma and lymph. (1992)

(1) all components of the renin-angiotensin system are represented in the renal interstitium, as reflected in lymph; (2) Ang II concentrations in renal lymph in vivo approximate arterial levels; (3) increased secretion of active renin into plasma during intrarenal infusion of captopril into denervated kidneys is due predominantly to renin activation; and (4) renal vascular resistance may depend on the concentration of Ang II in the renal interstitium.
Correction: Discovery and clinical introduction of first-in-class imipridone ONC201 (2021)

[This corrects the article DOI: 10.18632/oncotarget.11814.].
Interactions between LIM Domains and the LIM Domain-binding Protein Ldb1 (1998)

LIM domains mediate protein-protein interactions and, within LIM-homeodomain proteins, act as negative regulators of the transcriptional activation function of the protein. The recently described protein Ldb1 (also known as NLI; LIM domain-binding protein) binds LIM domains in vitro and synergizes with the LIM-homeodomain protein Xlim-1 in frog embryo microinjection experiments. In this study we localized the transcriptional activation domain of Xlim-1 to its carboxyl-terminal region, and characterized the interactions of the amino-terminally located LIM domains with Ldb1. Ldb1 binds LIM domains through its carboxyl-terminal region, and can form homodimers via its amino-terminal region. Optimal binding to Ldb1 required tandem LIM domains, while single domains could bind at lower but clearly measurable efficiency. In animal explant experiments, synergism of Ldb1 with Xlim-1 in the activation of downstream genes required both the region containing the dimerization domain of Ldb1 and the region containing the LIM-binding domain. The role of Ldb1 may be to recruit other transcriptional activators depending on the promoter context and LIM-homeodomain partner involved.
Exploitation of microbial biodiversity for the discovery and development of novel cosmeceutical agents – The “MICROSMETICS” project (2014)

In the framework of the newly funded FP7 Marie Curie Program “MICROSMETICS” [1], an innovative scientific and technological platform has been built aiming to the discovery of novel cosmeceuticals originating from global biodiversity using emerging and state of the art technologies in the field of biotechnology, natural products chemistry and applied microbiology. More specifically, MICROSMETICS scientific concept involves the discovery of novel natural products originating from global microbial biodiversity. Already existing culture collections will be exploited incorporating modern high throughput platforms (in silico & in vitro) for the rational and targeted selection of the most promising strains. Advanced analytical approaches and techniques are applied for the efficient, accelerated and advantageous isolation and identification of natural constituents, as well as the quality assessment of the lead products. A broad spectrum of bioassays and novel analytical approaches are incorporated for the evaluation of anti-ageing, more specifically anti-oxidant, skin-protecting, and skin-whitening activity, of all derived products. Attention is given to the selection and optimisation of fermentation technologies used for the production of final products in order to ensure sustainability. Within this frame, core scientific knowledge and lead compounds for further development are expected to be produced creating valuable synergies.
7,8-Dihydroxyflavone attenuates the release of pro-inflammatory mediators and cytokines in lipopolysaccharide-stimulated BV2 microglial cells through the suppression of the NF-κB and MAPK signaling pathways (2014)

7,8-Dihydroxyflavone (7,8-DHF), a member of the flavonoid family, has received considerable attention as a selective tyrosine kinase receptor B agonist. However, the pharmacological mechanisms responsible for its anti-inflammatory activities in microglial cells have yet to be elucidated. In this study, we evaluated the anti-inflammatory effects of this compound on the production of inflammatory mediators and cytokines in lipopolysaccharide (LPS)-stimulated murine BV2 microglial cells. At non-toxic concentrations, 7,8-DHF attenuated the production of nitric oxide (NO) and prostaglandin E2 (PGE2), by inhibiting inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) expression, respectively. Furthermore, the release and expression of inflammatory cytokines, including tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), were inhibited by 7,8-DHF. In addition, 7,8-DHF suppressed nuclear factor-κB (NF-κB) translocation and its transcriptional activity by blocking IκB (IκB)-α degradation; in addition, it exerted suppressive effects on the phosphorylation of mitogen-activated protein kinases (MAPKs). These results indicate that 7,8-DHF possesses therapeutic potential against neurodegenerative diseases that involve microglial activation.
Optical properties and laser performances of highly neodymium-doped YAG ceramics (2000)

Summary form only given. Diode-pumped microchip solid-state lasers have such advantages as compactness, high efficiency, high power, and low numbers of longitudinal and transverse modes. A wide variety of materials have been investigated to develop more efficient and higher power microchip lasers. Although Nd:YVO/sub 4/ is a suitable material for highly efficient microchip laser owing to its large absorption cross section, high-power operation is difficult because its thermo-mechanical properties are poor. On the other hand, while Nd:YAG has good thermal properties, highly efficient microchip laser has never been reported because high doping (>1 at.%) of neodymium into the YAG crystal is impossible, limiting pump absorption. We report measurements of the absorption spectra and the fluorescence lifetime of ceramic Nd:YAG in order to show that it is a promising material as a highly efficient and high power microchip laser. Moreover, we characterized its laser performance.
Modelling of free space optical (FSO) communications and networking with low earth orbit (LEO) satellites (2021)

In this talk, we examine the use of free space optical (FSO) links to and from low earth orbit (LEO) satellite systems and their incorporation within larger network architecture models. FSO link models are presented to predict dynamic link quality to and from a surface terminal to a LEO terminal. We also outline the design and development of network emulation and simulation capabilities to analyze the use of dynamic FSO-LEO link models within broader communication network architectures. We present an early network emulation demonstration of FSO-LEO link models involving data transfer between two surface observers and multiple opportunistic LEO satellite events.
Inside Back Cover: Aqueous Biphasic Systems for the Synthesis of Formates by Catalytic CO2 Hydrogenation: Integrated Reaction and Catalyst Separation for CO2‐Scrubbing Solutions (ChemSusChem 6/2017) (2017)

The Inside Back Cover picture shows the direct hydrogenation of CO2saturated aqueous scrubbing solutions to formate adducts in a biphasic system using a ruthenium catalyst. More details can be found in the Full Paper by Scott et al. on page 1085 in Issue 6, 2017 (DOI: 10.1002/cssc.201601814).
Investigation of Thermally Activated Delayed Fluorescence in Donor–Acceptor Organic Emitters with Time-Resolved Absorption Spectroscopy (2022)

In this contribution, we utilize multiple time-resolved and nonlinear optical measurements and quantum chemical simulations to investigate the excited-state dynamics of organic chromophores with thermally activated delayed fluorescent (TADF) characteristics. We are most interested in probing the influence of a phenylene linker on the photophysical properties of emitters composed of carbazole-based donors linked to either a phthalonitrile (PN) or diphenyltriazine (Trz) acceptor. The PN-acceptor compounds display a near double-fluorescence quantum yield (ΦF) enhancement in oxygen-free conditions. The fluorescent lifetime measurements indicate that the Trz-acceptor compounds are more efficient fluorescence emitters and quickly go from a delocalized to localized state. They also reveal that only the PN-acceptor compounds display a long-lived emissive lifetime component associated with TADF activity. Analysis of the nanosecond transient absorption spectra and kinetics reveals long-lived excited-state absorption (ESA) bands associated with triplet states for the PN-acceptor compounds. No ESA bands were observed for the Trz-acceptor compounds, despite observing a quantum yield enhancement for the Trz-acceptor compounds after oxygen purging. From the transient absorption measurements, it was determined that the PN-acceptor compounds have reverse intersystem crossing rates (krISC) that are able to compete with other triplet decay pathways. From quantum chemical calculations, it is proposed that inclusion of the phenylene linker prevents sufficient highest occupied molecular orbital/lowest unoccupied molecular orbital separation and suppresses TADF activity and that directly linking multiple donors to the acceptor will aid in achieving TADF activity.
Reversible Silver Electrodeposition from Boron Cluster Ionic Liquid (BCIL) Electrolytes (2017)

Electrochemical systems offer a versatile means for creating adaptive devices. However, the utility of electrochemical deposition is inherently limited by the properties of the electrolyte. The development of ionic liquids enables electrodeposition in high-vacuum environments and presents opportunities for creating electrochemically adaptive and regenerative spacecraft components. In this work we developed a silver-rich, boron cluster ionic liquid (BCIL) for reversible electrodeposition of silver films. This air and moisture stable electrolyte was used to deposit metallic films in an electrochemical cell to tune the emissivity of the cell in situ, demonstrating a proof-of-concept design for spacecraft thermal control.
Synthesis of hierarchical nanocrystal-based mesoporous materials for electrochemical supercapacitors (2012)

The ability to construct well-defined and controlled hierarchical nanostructured porous architectures is desirable for enhancing the performance of electrochem. pseudocapacitors. Here, we propose design rules for improving capacitive energy storage: use of redox-active materials, high surface area for high capacity, mesoporosity for solvent diffusion, and good electronic cond. Previous work on TiO2 nanocrystal-based porous films satisfied many of these requirements. In this work, we build on those initial results using polymer templating of preformed nanocrystals to fabricate high surface area redox-active materials, including Mn3O4 and MnFe2O4. In addn. we have prepd. mesoporous nanocrystal-based films of tin-doped indium oxide (ITO) coated with V2O5. The ITO scaffold provides a conductive pathway and facilitates electron-transfer reactions throughout the V2O5 layer. In these systems, the mesoscale porosity allows facile electrolyte diffusion throughout the material, while the nanocrystals embedded in the pore walls provide a high surface area with ample redox-active sites.
Accurate design and analysis of spherical beam volume holograms for sensing applications (2003)

We present an accurate model for design and analysis of volume holograms recorded by spherical reference beams. We explain how it can be used for analysis of incoherent Raman signals in bio and environmental sensing. For such applications, conventional models based on paraxial approximations must be replaced by accurate model.
Synthesis of New High Energy Density Matter (HEDM): Extra High Energy Oxidizers and Fuels (2000)

Abstract : This program focused on the discovery and synthesis of new, extra-high energy oxidizers and fuels for the High Energy Density Matter (HEDM) program. The goals included the preparation of new compounds having unusual bonding to yield high energy, dense materials for propellant applications. The specific objectives for this program were: (1) to develop new fuels and oxidizers for propellant applications. The materials must be simple to make (cubane is difficult); be storable and usable; have significantly improved performance over conventional materials; develop burn rate accelerators to improve and accelerate combustion. (2) Invent new compositions of matter to meet needs of the program. The requirements for the new materials included simplicity of synthesis and good long-term stability to make these material candidates for propellant applications. The work was directed primarily toward the synthesis of highly energetic fuels and fuel additives because this area has been relatively unexplored, although this report discusses a new oxidizer family with great promise. A new concept of combinatorial type synthesis for energetic materials is also discussed in this report.
Transplantation of high fat fed mouse microbiota into zebrafish larvae identifies MyD88‐dependent acceleration of hyperlipidaemia by Gram‐positive cell wall components (2021)

Gut dysbiosis is an important modifier of pathologies including cardiovascular disease but our understanding of the role of individual microbes is limited. Here, we have used transplantation of mouse microbiota into microbiota-deficient zebrafish larvae to study the interaction between members of a mammalian high fat diet-associated gut microbiota with a lipid rich diet challenge in a tractable model species. We find zebrafish larvae are more susceptible to hyperlipidaemia when exposed to the mouse high fat-diet-associated microbiota and that this effect can be driven by two individual bacterial species fractionated from the mouse high fat-diet-associated microbiota. We find Stenotrophomonas maltophilia increases the hyperlipidaemic potential of chicken egg yolk to zebrafish larvae independent of direct interaction between S. maltophilia and the zebrafish host. Colonization by live, or exposure to heat-killed, Enterococcus faecalis accelerates hyperlipidaemia via host MyD88 signaling. The hyperlipidaemic effect is replicated by exposure to the Gram-positive toll-like receptor agonists peptidoglycan and lipoteichoic acid in a MyD88-dependent manner. In this work, we demonstrate the applicability of zebrafish as a tractable host for the identification of gut microbes that can induce conditional host phenotypes via microbiota transplantation and subsequent challenge with a high fat diet.
Planer frequency reconfigurable antenna for mobile terminals (2012)

We propose a novel design of a frequency reconfigurable antenna. The electrical length and return loss of the antenna are reconfigured by RF-MEMS switches. The area of the antenna element is 15 × 50 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The measured total efficiency of the antenna is higher than -3 dB at almost all frequencies between 0.78 GHz and 5.85 GHz. This antenna is suitable for future mobile terminals, which include many radio systems.
Marine Natural Products as Lead Anti-HIV Agents (2003)

Current anti-HIV drugs have extreme side effects and resistance to these drugs develops rapidly. The marine environment holds an unprecedented number of unusual chemical structural classes with activity against HIV. We review the literature on anti-HIV activity of marine natural products and discuss the efficacy of different structural classes.
A Recombinant Human Monoclonal Antibody to Human Metapneumovirus Fusion Protein That Neutralizes Virus In Vitro and Is Effective Therapeutically In Vivo (2007)

Human metapneumovirus (hMPV) is a recently discovered paramyxovirus that is a major cause of lower-respiratory-tract disease. hMPV is associated with more severe disease in infants and persons with underlying medical conditions. Animal studies have shown that the hMPV fusion (F) protein alone is capable of inducing protective immunity. Here, we report the use of phage display technology to generate a fully human monoclonal antibody fragment (Fab) with biological activity against hMPV. Phage antibody libraries prepared from human donor tissues were selected against recombinant hMPV F protein with multiple rounds of panning. Recombinant Fabs then were expressed in bacteria, and supernatants were screened by enzyme-linked immunosorbent assay and immunofluorescent assays. A number of Fabs that bound to hMPV F were isolated, and several of these exhibited neutralizing activity in vitro. Fab DS7 neutralized the parent strain of hMPV with a 60% plaque reduction activity of 1.1 mug/ml and bound to hMPV F with an affinity of 9.8 x10(-10) M, as measured by surface plasmon resonance. To test the in vivo activity of Fab DS7, groups of cotton rats were infected with hMPV and given Fab intranasally 3 days after infection. Nasal turbinates and lungs were harvested on day 4 postinfection and virus titers determined. Animals treated with Fab DS7 exhibited a >1,500-fold reduction in viral titer in the lungs, with a modest 4-fold reduction in the nasal tissues. There was a dose-response relationship between the dose of DS7 and virus titer. Human Fab DS7 may have prophylactic or therapeutic potential against severe hMPV infection.
Trade-offs in loop transformations (2009)

Nowadays, multimedia systems deal with huge amounts of memory accesses and large memory footprints. To alleviate the impact of these accesses and reduce the memory footprint, high-level memory exploration and optimization techniques have been proposed. These techniques try to more efficiently utilize the memory hierarchy. An important step in these optimization techniques are loop transformations (LT). They have a crucial effect on later data memory footprint optimization steps and code generation. However, the state-of-the-art work has focused only on individual objectives. The main one in literature involves improving the locality of data accesses, and thus reducing the data memory footprint. It does not consider the trade-offs in the LT step in relation to successive optimization steps. Therefore, it is not globally efficient in mapping the application on the target platform. In this article we will discuss several trade-offs during the loop transformations. To our knowledge, we are the first ones considering these global trade-offs. Previous work always gave mostly one solution, having the best locality and thus the optimized memory footprint, even though some research in two-dimensional trade-offs in this area exists as well. We start from this state-of-the-art solution with minimal footprint. We show that by sacrificing the footprint, we can obtain gains in data reuse (crucial for energy reduction) and reduce the control-flow complexity. We demonstrate our approach on a real-life application, namely the QSDPCM video coder. At the end, we show that considering trade-offs for this application leads to 16% energy reduction in a two-layer memory subsystem and 10% cycle reduction on the ARM platform.
Bandwidth efficient and flexible 5G fronthaul (2018)

This paper provides an overview of the numerous fronthaul interfaces specifications initiatives launched in several fora and SDO, and describes the main requirement on transport. Focus is given on Low layer interfaces, and massive MIMO.
Mass landscapes of seven scorpion species: The first analyses of Australian species with 1,5-DAN matrix. (2012)

Scorpion venoms have been studied for over fifty years; however, the majority of research has focussed primarily on medically important Buthidae species. Additionally, venoms of the estimated 200 species of scorpion native to Australia have received very little attention. The first venom mass profiles of six non-buthid and one buthid scorpion species are presented herein, four of which are endemic to Australia. While masses under 5 kDa dominated the venoms of all species, the buthid venom contained considerably more masses between 7 and 8 kDa than those of the non-buthids, corroborating the emergent trend that buthids are richer in long-chain neurotoxins than non-buthids. The Australian scorpion venom fractions were also analysed with the relatively new MALDI-ToF matrix 1,5-DAN. Over forty partial sequences were obtained, the majority of which are homologous to scorpion antimicrobials such as opistoporin and IsCT2. Overall, this study is the single most comprehensive mass spectrometric analysis of scorpion venom landscapes to date and provides an insight into untapped Australian species.