gebhart/patrepeval huggingface dataset:
A Natural Product Telomerase Activator as Part of a Health Maintenance Program: Metabolic and Cardiovascular Response (2013)

A short average telomere length is associated with low telomerase activity and certain degenerative diseases. Studies in animals and with human cells confirm a causal mechanism for cell or tissue dysfunction triggered by critically short telomeres, suggesting that telomerase activation may be an approach to health maintenance. Previously, we reported on positive immune remodeling in humans taking a commercial health maintenance program, PattonProtocol-1, composed of TA-65® (a natural product-derived telomerase activator) and other dietary supplements. In over a 5-year period and an estimated 7000 person-years of use, no adverse events or effects have been attributed to TA-65 by physicians licensed to sell the product. Here we report on changes in metabolic markers measured at baseline (n=97-107 subjects) and every 3-6 months (n=27-59 subjects) during the first 12 months of study. Rates of change per year from baseline determined by a multi-level model were -3.72 mg/dL for fasting glucose (p=0.02), -1.32 mIU/mL for insulin (p=0.01), -13.2 and -11.8 mg/dL for total cholesterol and low-density lipoprotein cholesterol (LDL-C) (p=0.002, p=0.002, respectively), -17.3 and -4.2 mmHg for systolic and diastolic blood pressure (p=0.007 and 0.001, respectively), and -3.6 μmole/L homocysteine (p=0.001). In a subset of individuals with bone mineral density (BMD) measured at baseline and 12 months, density increased 2.0% in the spine (p=0.003). We conclude that in addition to apparent positive immune remodeling, PattonProtocol-1 may improve markers of metabolic, bone, and cardiovascular health.
Standard CMOS Hall-Sensor with Integrated Interface Electronics for a 3D Compass Sensor (2007)

A smart compass sensor has been developed in standard CMOS with integrated signal conditioning and interface electronics. The compass sensors measure the horizontal components of the earth's magnetic field, which has a typical field strength of 25muT. The sensor's offset is 4muT (3sigma), and its offset stability is less than 0.25muT/week. Due to this low offset stability, the detection level is only limited by system noise. By using an improved chopper amplifier in the front-end the system noise has been reduced to 0.12muT/radicHz. In order to measure all three components of the earth's magnetic field, each sensor is packaged in a custom SFN8 package, which enables the necessary orthogonal alignment of three sensors. The presented 3D sensor module consists of three daisy-chained sensors, and illustrates the ease-of-use of a smart sensor with integrated bus (SPI/muwire) interface. Apart from a single decoupling capacitor, no external components are necessary to read out the sensor signals, which reduces system costs.
Current Status of the Search for Melanoma-Specific Antigens (1981)

Malignant melanoma has a reputation as one of the most capricious and aggressive human cancers. The incidence and mortality have been rising in developed countries at a rate exceeding that of all other cancers except lung cancer (Lee and Carter, 1970). At present, in the United States, 10,000 individuals develop cutaneous malignant melanoma each year, an incidence slightly higher than that of Hodgkin's disease (Levin and Baranovsky, 1976). Despite its reputation, the overall survival from melanoma is better than that from most common solid tumors, with approximately 70% of patients surviving at 5 years. When metastases are not evident, i.e., stage I melanoma, 85% of patients survive 5 years or more with treatment. However, once melanoma has metastasized, more than two-thirds of patients will die from their disease. These advanced stages of disease have been particularly resistant to conventional treatments; therapy of metastatic melanoma remains at this time generally unsatisfactory. The epidemiology, clinical features, and immunology of melanoma have been extensively reviewed elsewhere (Clark et at., 1977; Lee, 1975; Kopf et at., 1977; Ferrone and Pellegrino, 1979; McCabe et at., 1979; Irie et at.,
GLYCEMIC AND INSULINEMIC RESPONSES TO SMALL REPEATED CARBOHYDRATE FEEDINGS BEFORE EXERCISE 1664 (1997)

Carbohydrate (CHO) feedings in the hour prior to exercise have been shown to result in a relative hypoglycemic response near the onset of the exercise in some cases. This investigation was undertaken to determine whether consuming several small feedings, rather than the traditional single bolus, would alter blood glucose and insulin responses during rest and exercise. Eight trained cyclists ingested either 22.5, 45, or 75 total grams of maltodextrin and dextrose dissolved in 473 ml of water or an equal volume of placebo (PL). Drinks were divided into 4 portions and consumed at 15 min intervals in the hour before a 120 min ride at 65-70% VO2max. Serum glucose values were similarly elevated by each of the CHO feedings at rest, then fell significantly (p<0.05) below baseline and PL at 15 min of exercise. Glucose concentrations immediately prior to exercise (≈5.3 mmol·l-1) and at the 15 min nadir (≈3.2 mmol·l-1) were similar in each of the CHO trials and thus, unrelated to the amount consumed. Insulin concentrations also increased rapidly during rest then fell sharply at the onset of exercise. Total area under the insulin curve was higher in the 75 g trial than both 22.5 g and PL while the 45 g trial exceeded PL. No differences were found in CHO oxidation, perceived exertion or other physiological variables among treatments. At least 2 subjects in each CHO trial expressed subjective feelings of fatigue and exhibited blood glucose values <2.9 mmol·l-1 at 15 min, but all recovered by 30 min and successfully completed the exercise. The conclusion is that CHO consumed during the hour before exercise, even when taken in several small doses, has the potential to produce transient hypoglycemia near the onset of exercise. Additionally, the magnitude of the response appears to be unrelated to the amount of CHO ingested and the insulin concentration.
Correction: Urinary Bisphenol A Concentration and Angiography-Defined Coronary Artery Stenosis (2012)

Background: Bisphenol A is widely used in food and drinks packaging. There is evidence of associations between raised urinary bisphenol A (uBPA) and increased incidence of reported cardiovascular diagnoses.
Magnetic ground and remanent states of synthetic metamagnets with perpendicular anisotropy (2011)

In this work, we summarize our theoretical results within a phenomenological micromagnetic approach for magnetic ground state and nonequilibrium states as topological magnetic defects in multilayers with strong perpendicular anisotropy and antiferromagnetic (AF) interlayer exchange coupling (IEC), e.g. [Co/Pt(Pd)]/Ru(Ir, NiO). We give detailed analysis of our model together with the most representative results which elucidate common features of such systems. We discuss phase diagrams of the magnetic ground state, and compare solutions of our model with experimental data. A model to assess the stability of so-called tiger tail patterns is presented. It is found that these modulated topological defect cannot be stabilized by an interplay between magnetostatic and IEC energies only. It is argued that tiger tail patterns arise as nuclei of ferro-stripe structure in AF domain walls and that they are stabilized by domain wall pinning.
Methane production in aerobic oligotrophic surface water in the central Arctic Ocean (2010)

Abstract. A methane surplus relative to the atmospheric equilibrium is a frequently observed feature of ocean surface water. Despite the common fact that biological processes are responsible for its origin, the formation of methane in aerobic surface water is still poorly understood. We report on methane production in the central Arctic Ocean, which was exclusively detected in Pacific derived water but not nearby in Atlantic derived water. The two water masses are distinguished by their different nitrate to phosphate ratios. We show that methane production occurs if nitrate is depleted but phosphate is available as a P source. Apparently the low N:P ratio enhances the ability of bacteria to compete for phosphate while the phytoplankton metabolite dimethylsulfoniopropionate (DMSP) is utilized as a C source. This was verified by experimentally induced methane production in DMSP spiked Arctic sea water. Accordingly we propose that methylated compounds may serve as precursors for methane and thermodynamic calculations show that methylotrophic methanogenesis can provide energy in aerobic environments.
ubiI, a New Gene in Escherichia coli Coenzyme Q Biosynthesis, Is Involved in Aerobic C5-hydroxylation (2013)

Coenzyme Q (ubiquinone or Q) is a redox-active lipid found in organisms ranging from bacteria to mammals in which it plays a crucial role in energy-generating processes. Q biosynthesis is a complex pathway that involves multiple proteins. In this work, we show that the uncharacterized conserved visC gene is involved in Q biosynthesis in Escherichia coli, and we have renamed it ubiI. Based on genetic and biochemical experiments, we establish that the UbiI protein functions in the C5-hydroxylation reaction. A strain deficient in ubiI has a low level of Q and accumulates a compound derived from the Q biosynthetic pathway, which we purified and characterized. We also demonstrate that UbiI is only implicated in aerobic Q biosynthesis and that an alternative enzyme catalyzes the C5-hydroxylation reaction in the absence of oxygen. We have solved the crystal structure of a truncated form of UbiI. This structure shares many features with the canonical FAD-dependent para-hydroxybenzoate hydroxylase and represents the first structural characterization of a monooxygenase involved in Q biosynthesis. Site-directed mutagenesis confirms that residues of the flavin binding pocket of UbiI are important for activity. With our identification of UbiI, the three monooxygenases necessary for aerobic Q biosynthesis in E. coli are known.
Towards Green Ammonia Synthesis through Plasma‐Driven Nitrogen Oxidation and Catalytic Reduction (2020)

Ammonia is an industrial large-volume chemical, with its main application in fertilizer production. It also attracts increasing attention as a green-energy vector. Over the past century, ammonia production has been dominated by the Haber-Bosch process, in which a mixture of nitrogen and hydrogen gas is converted to ammonia at high temperatures and pressures. Haber-Bosch processes with natural gas as the source of hydrogen are responsible for a significant share of the global CO<sub>2</sub> emissions. Processes involving plasma are currently being investigated as an alternative for decentralized ammonia production powered by renewable energy sources. In this work, we present the PNOCRA process (plasma nitrogen oxidation and catalytic reduction to ammonia), combining plasma-assisted nitrogen oxidation and lean NO<sub>x</sub> trap technology, adopted from diesel-engine exhaust gas aftertreatment technology. PNOCRA achieves an energy requirement of 4.6 MJ mol<sup>-1</sup> NH<sub>3</sub> , which is more than four times less than the state-of-the-art plasma-enabled ammonia synthesis from N<sub>2</sub> and H<sub>2</sub> with reasonable yield (>1 %).
Review: Model Driven Architecture (2004)

Model Driven Architecture David Frankel John Wiley & Sons ISBN 0-471-3192-01 £29.95
Dynamic reconfiguration of CPU and WebSphere on IBM pSeries servers (2004)

Abstract This paper studies the effects that dynamic reconfiguration (DR) has on a WebSphere workload while CPUs are dynamically added to and removed from the underlying AIX instance. DR is a new technology available in AIX 5.2. This study shows that the resource allocations for a complex and function‐rich middleware system such as WebSphere can be efficiently and dynamically managed by the DR technology, without WebSphere having to explicitly accommodate for the DR features of the operating system. Copyright © 2004 John Wiley &amp; Sons, Ltd.
Noninvasive measurements of body composition and body water via quantitative magnetic resonance, deuterium water, and dual-energy x-ray absorptiometry in cats (2013)

QMR was useful for determining body composition in cats; precision was improved over DXA. Quantitative magnetic resonance can be used to safely and rapidly acquire data without the need for anesthesia, facilitating frequent monitoring of weight changes in geriatric, extremely young, or ill pets. Compared with the D2O dilution method, QMR correction equations provided accurate data over a range of body compositions.
Cell-Free Data Power Control Via Scalable Multi-Objective Bayesian Optimisation (2022)

Cell-free multi-user multiple input multiple output networks are a promising alternative to classical cellular architectures, since they have the potential to provide uniform service quality and high resource utilisation over the entire coverage area of the network. To realise this potential, previous works have developed radio resource management mechanisms using various optimisation engines. In this work, we consider the problem of overall ergodic spectral efficiency maximisation in the context of uplink-downlink data power control in cell-free networks. To solve this problem in large networks, and to address convergence-time limitations, we apply scalable multi-objective Bayesian optimisation. Furthermore, we discuss how an intersection of multi-fidelity emulation and Bayesian optimisation can improve radio resource management in cell-free networks.
Context in Conversation (2012)

This chapter contains sections titled: Context modeling and aggregation Context-based speech applications: Conspeakuous Context-based speech applications: Responsive information architect Conclusion Bibliography
The influence of visual salience on video consumption behavior (2015)

In an increasingly competitive media environment, producers of online content need analytics that can predict the success of a video. In recent years the field of visual computation has produced a variety of mathematical models that quantify an image's salience, that is, its potential to capture attention. To test how a video's content might predict its success, we applied the standard saliency model of Itti, Koch, and Niebur [1] to more than 1000 video clips that were broadcast on a large video streaming website. We also obtained fine-grained data on the viewership of these clips. Based on a survival analysis, we find that people prefer more salient videos. The results were robust towards the inclusion of other predictors such as the genre of the video, but not to video length, which remains correlated with salience even after comparing videos only within show and genre. Our analyses suggest that visual salience provides an objective and easy-to-compute supplement to previously suggested predictors of video consumption behavior.
Robotics: The Algorithmic Perspective (1998)

This volume gathers together cutting-edge research from the Third Workshop on Algorithmic Foundations of Robotics and gives a solid overview of the state of the art in robot algorithms. The papers cover core problems in robotics, such as motion planning, sensor-based planning, manipulation, and assembly planning. They also examine the application o
Supplementary Figure 7 from A687V EZH2 Is a Driver of Histone H3 Lysine 27 (H3K27) Hypertrimethylation (2023)

&lt;p&gt;Supplementary Figure 7: Comparison of the active sites and residue numbering of multiple related lysine methyltransferases&lt;/p&gt;
r Length Model for Contact o-Layer Systems with A ayer Coupling Under the ta (1996)

An improved analytical solution to the two-layer transmission line model for determining contact resistances to semiconductor layers is presented. In contrast to previously published two-layered analyses, the present solution is valid for arbitrary strength linear coupling between the two conducting layers in the region under the contact. A comparison of limiting cases and a physical interpretation of the differences between predictions of this model and previous models are presented. The predicted resistance versus pad separation behavior ob- tained from the present model and from a two-layer model which assumed weak interlayer coupling beneath the contacts are compared for idenaical physical structures. Experimental data for contact resistance measurements on a double-barrier resonant tunneling diode structure are presented. The measured data exhibit the nonlinear resistance versus pad spacing predicted by the model and show a dependence on current level which can be modeled as a variation of the interlayer coupling strength. The values of the contact resistance, interlayer coupling resistance and sheet resistance extracted from the measured data using the present model and the weakly coupled model are presented and compared with independently measured and calculated param- eters.
Analysis of Twenty-Two Performance Properties of Diesel, Gasoline, and Jet Fuels Using a Field-Portable Near-Infrared (NIR) Analyzer (2016)

The change in custody of fuel shipments at depots, pipelines, and ports could benefit from an analyzer that could rapidly verify that properties are within specifications. To meet this need, the design requirements for a fuel analyzer based on near-infrared (NIR) spectroscopy, such as spectral region and resolution, were examined. It was found that the 1000 to 1600 nm region, containing the second CH overtone and combination vibrational modes of hydrocarbons, provided the best near-infrared to fuel property correlations when path length was taken into account, whereas 4 cm(-1) resolution provided only a modest improvement compared to 16 cm(-1) resolution when four or more latent variables were used. Based on these results, a field-portable near-infrared fuel analyzer was built that employed an incandescent light source, sample compartment optics to hold 2 mL glass sample vials with ∼1 cm path length, a transmission grating, and a 256 channel InGaAs detector that measured the above stated wavelength range with 5-6 nm (∼32 cm(-1)) resolution. The analyzer produced high signal-to-noise ratio (SNR) spectra of samples in 5 s. Twenty-two property correlation models were developed for diesel, gasoline, and jet fuels with root mean squared error of correlation - cross-validated values that compared favorably to corresponding ASTM reproducibility values. The standard deviations of predicted properties for repeat measurements at 4, 24, and 38℃ were often better than ASTM documented repeatability values. The analyzer and diesel property models were tested by measuring seven diesel samples at a local ASTM certification laboratory. The standard deviations between the analyzer determined values and the ASTM measured values for these samples were generally better than the model root mean squared error of correlation-cross-validated values for each property.
Comparison of three mathematical models of egg production (1982)

1. Egg production of four‐way crosses of seven commercial stocks of White Leghorns was summarised for each hen into 28‐d periods starting from the day of first egg. 2. The exponential models of McMillan and of Wood and a linear regression were fitted to the results for individual hens, as well as to the mean results for periods of groups of hens. 3. Overall, the McMillan model gave the best results with mean R2 of 0.71 from fitting it to the results for 223 individuals with sixteen 28‐d periods each and R2 of 0.97 from fitting it to the period means for groups. The respective R2 values were 0.68 and 0.95 for the Wood model and 0.60 and 0.90 for the linear regression.
New insights in the pathogenesis of T-cell lymphomas (2018)

Understanding of PTCL pathogenesis has substantially improved, and oncogenic events have been identified. The current challenge is to mount efficient therapeutic strategies targeting these aberrations to improve patients' outcome.
STUDYING THE ROLE OF ApoE IN ALZHEIMER'S DISEASE PATHOGENESIS USING A SYSTEMS BIOLOGY MODEL (2013)

Alzheimer's disease (AD) is the most common form of dementia. Even with its well-known symptoms of memory loss and well-characterized pathology of beta amyloid (Aβ) plaques and neurofibrillary tangles, the disease pathogenesis and initiating factors are still not well understood. To tackle this problem, a systems biology model has been developed and used to study the varying effects of variations in the ApoE allele present, as well as the effects of short term and periodic inflammation at low to moderate levels. Simulations showed a late onset peak of Aβ in the ApoE4 case that lead to localized neuron loss which could be ameliorated in part by application of short-term pro-inflammatory mediators. The model that has been developed herein represents one of the first attempts to model AD from a systems approach to study physiologically relevant parameters that may prove useful to physicians in the future.
Determination of precise X-ray diffraction angles by fast Fourier transform (1987)

A new analytical method is presented for the separation of two or more closely overlapping X-ray diffraction lines using the narrowly distributed Gaussian function and one-dimensional fast Fourier transform pair. To test the method, the diffraction lines associated with characteristic Kα1 and Kα2 rays are measured by an X-ray diffractometer using a Brazilian quartz powder as a standard sample. It is found that the observed diffraction lines can be completely separated into Kα1 and Kα2 lines and that the accuracy of those diffraction angles is better than 2 × 10-4.
Selected Contribution: Association of gender-related LMP2 inactivation with autoimmune pathogenesis (2001)

Recent results in an animal model of autoimmune diabetes, the nonobese diabetic (NOD) mouse, suggest a hypothesis to explain the role of major histocompatibility complex (MHC) in autoimmunity. The genome MHC region contains immune response genes that are important for T cell education and antigen presentation by MHC molecules. Two such genes encoding the LMP2 and LMP7 proteasome subunits are located in this high-risk MHC genomic region. Proteasome containing the LMP2 subunit is essential for T cell education and proteolytically activates transcription factor nuclear factor-kappaB. Splenocytes of NOD mouse with marked female specificity for disease expression are defective in LMP2 expression. The spontaneous defective LMP2 expression in NOD mice, which is gender biased toward female cohorts, is restricted to select lymphoid and myeloid cells and is developmentally controlled with lowered LMP2 protein and heightened tumor necrosis factor-alpha-induced apoptosis. These defects are apparent only after approximately 7 wk of age. These data suggest a proteasome role in autoimmune progression, and a gender developmental and lineage restriction of LMP2 expression may contribute to the diverse autoimmune characteristics preferentially observed in female NOD mice.