gebhart/patrepeval huggingface dataset:
Association of serum levels of the growth factor GP88 with disease progression in breast cancer patients (2009)

e22021 Background: The autocrine growth factor GP88 is an important player in breast cancer. GP88 is expressed in human BC tumors in correlation with their tumorigenicity. Increased GP88 expression was associated with anti-estrogen therapy resistance in ER+ cells and Herceptin resistance in Her-2 overexpressing breast tumors. Inhibition of GP88 expression inhibited tumor incidence and growth in nude mice. Immunohistochemical studies have shown that GP88 is expressed in invasive ductal carcinomas (IDC) and that high GP88 expression correlated with increased recurrence and mortality. Since GP88 is found in serum, we hypothesized that GP88 was elevated in the sera of breast cancer patients compared to healthy individuals and that GP88 serum level increases with disease progression. Methods: An IRB approved prospective study was established at the University of Maryland Breast Clinic to determine the serum level of GP88 in breast cancer patients (BC pts). Approximately 5 ml of blood was drawn every three months. GP88 serum concentration was determined in triplicate by human GP88 enzyme immunoassay. 190 BC pts were accrued. Sera from healthy volunteers (HV) were obtained to establish GP88 baseline. BC patient characteristics: Caucasian- 91, African American-92, Asian-6; median age, 51 (range 29- 86), stage I - 48, II - 52, III - 26, IV - 63. Results: Median serum GP88 level was 28.7 ng/ml (range 16.6–38.2) in HV, 40.7 ng/ml (range 6.4–100) in early stage (stage 1 -3) BC pts (p- value = 0.007) and 45.3 ng/ml (range 9.8 to 158.4) in stage 4 BC patients (p- value= 0.0007). Statistically significant increase in serum GP88 level was found in early stages as well as in metastatic disease when compared to HV. In addition, patients that were initially diagnosed with early stage disease but recurred showed a 5 to 10 fold increase in their GP88 serum levels. Conclusions: GP88 serum level is significantly higher in the sera of BC than HV subjects. Moreover, GP88 serum level increased in association with disease recurrence and progression. This study identifies GP88 as a measurable biomarker for disease progression not only at the tissue but also at the serum level. These results are also interesting since GP88 is also a therapeutic target of malignant progression of breast carcinoma. No significant financial relationships to disclose.
Defense Mechanisms in a Community-Based Sample of Female Adolescents with Partial Eating Disorders (2003)

The combined use of immature and neurotic defenses may be associated with a greater risk to develop a partial ED in adolescent females.
Urolithiasis, Endourology and Laparoscopy (2008)

No AccessJournal of UrologyAdult Urology1 Apr 2008Urolithiasis, Endourology and Laparoscopy Ralph ClaymanM.D. Ralph ClaymanRalph Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2007.12.017AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Urolithiasis, Endourology and Laparoscopy." The Journal of Urology, 179(4), p. 1424 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4April 2008Page: 1424 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Ralph Clayman More articles by this author Expand All Advertisement PDF DownloadLoading ...
GENERALIZED DERIVATIONS FOR MIXTURES USING THE VIRIAL EQUATION: APPLICATION TO FUGACITY (1995)

Abstract Calculation of mixture properties using the virial equation of state (VEOS) becomes tedious when the expression contains more than the second virial term. This paper describes a derivation procedure which permits relatively simple extension to any number of virial terms. We have used the fugacity derivation as an example of using the new technique and provide an equation for the fugacity coefficient using any number of terms and any number of components.
Doubly Activated Cyclopropanes as Synthetic Precursors for the Preparation of 4-Nitro- and 4-Cyano-dihydropyrroles and Pyrroles (2005)

[reaction: see text] 1-Nitro- and 1-cyano-cyclopropyl ketones have been prepared in an expedient manner from cyclopropanation reactions of alkenes by diazo compounds or in situ-generated phenyliodonium ylides catalyzed by Rh(II) carboxylates. The doubly activated cyclopropanes were used as synthetic precursors for the regiospecific synthesis of 4-nitro- and 4-cyano-dihydropyrroles upon treatment with primary amines. Oxidation of the dihydropyrroles with DDQ allows rapid access to densely functionalized pyrroles.
Electronmicroscopic observation of ultrafine particles. (1987)

Methods for the production of fine particles which are suited for electronmicroscopic observation are briefly introduced. The usefulness of the ultra-high resolution electron microscopy for the study of fine particles is emphasized, in particular, in looking into the details of crystal structures, crystalline defects, morphologies and surface structures of small particles. As some examples, structural changes of metal clusters less than 100 Å in size which are caused by the electron beam irradiation in the microscope, structural details of spherical particles of Si and alumina, and surface coatings of small particles by carbon, are described.
Grating-based holographic X-ray diffraction: theory and application to confined fluids (2009)

A grating-based holographic X-ray diffraction technique has been developed for reconstructing density profiles of nano-scale fluids confined in channel arrays. Within this approach, the reference wave is due to diffraction from the fabricated channel array, whereas the object wave is generated by the confinement-induced ordering of the fluid. The ensemble-averaged density profile of the fluid across the confining channel, which constitutes a weak phase object, is then determined in a model-independent manner from the interference between the reference and object waves by direct Fourier inversion. The validity of the linear holographic approach and its connection to the autocorrelation function, the inclusion of channel tapering, and volume-diffraction effects are discussed in detail.
Evaluation of the procoagulant properties of a newly developed platelet modified lysate product (2020)

BACKGROUND Platelet transfusion is associated with logistical problems with the national storage guidelines of platelets. This results in decreased function in vivo as a result of the platelet storage lesion, and complications such as allergic or hemolytic reactions and thrombosis. We evaluated a new, freshly prepared platelet modified lysate (PML) product designed to be more procoagulant than fresh and stored platelets. METHODS Fresh platelets were concentrated, sonicated, and centrifuged to produce PML. Samples of both washed and unwashed PML were evaluated for particle size, concentration, and activity, and then tested for clot kinetics and thrombin generation. PML samples were also stored at various temperatures for durations up to 6 months and evaluated for clot kinetics and thrombin generation throughout. RESULTS PML showed significantly higher concentration of platelet microparticles, increased procoagulant properties, and increased thrombin generation as compared to fresh and stored platelets. In addition, PML maintained its clot kinetics over a 6‐month storage period with variable storage conditions. CONCLUSIONS The newly proposed PML product is more procoagulant, stable, and has additional potential applications than currently available platelet products. Further studies will be performed to assess its functions in vivo and to assess thrombotic potential.
Prognostic Factors and Treatment Outcome in Lymphocyte Predominant and Classical Hodgkin’s Lymphoma: A Comprehensive Analysis of the German Hodgkin Study Group. (2006)

Abstract Introduction: Lymphocyte predominant Hodgkin lymphoma (LPHL) differs in histological and clinical presentation from classical Hodgkin lymphoma (cHL). Treatment of LPHL patients using standard approaches leads to complete remission (CR) in more than 95% of patients. However, differences in terms of relapse rates, overall survival (OS) and freedom from treatment failure (FFTF) between LPHL and cHL patients were suggested by a recent intergroup analysis. To obtain a more comprehensive picture, we reviewed all LPHL-cases registered in the GHSG database comparing patient characteristics and treatment outcome with cHL patients. Patients and methods: We retrospectively analyzed 8298 HL patients treated within the GHSG trials (HD4 to HD12). 394 patients had LPHL and 7904 cHL. From 394 LPHL patients, 63% were in early favorable stage, 16% in early unfavorable and 21% in advanced stage of disease. Of the 7904 cHL patients analyzed, 22% were in early favorable, 39% in early unfavorable and 39% in advanced stages. 9% of LPHL patients had B symptoms compared to 40% in cHL patients. Results: 91% LPHL vs. 86% cHL patients in early favorable stages, 86% vs. 83% in early unfavorable and 79% vs. 75% in advanced stages reached CR/CRu. 0.3% LPHL patients developed progressive disease (PD) compared to 3.7% cHL patients. The relapse rate of LPHL patients was very similar to cHL (8.1% vs. 7.9%). There were 2.5% secondary malignancies in LPHL and 3.7% in cHL patients. 4.3% LPHL patients and 8.8% cHL patients died. The FFTF rates for LPHL and cHL patients at a median observation of 41 or 48 months were 88% and 82% (p=0.0093), respectively. The OS for LPHL and cHL patients was 96% and 92%, respectively (p=0.0166). The analysis between LPHL stages showed significant differences in FFTF (p=0.0239). According to a multiple Cox-regression analysis, advanced stage (p=0.0089) and lymphocytes &amp;lt; 8% of white cell count was shown as negative prognostic factors for FFTF and age ≥ 45 years (p=0.008) as negative factor for OS in LPHL patients. Hb value &amp;lt; 10.5 g/dl was shown as negative factor for both, FFTF and OS (p=0.0125, p=0.0002). Conclusion: This is the largest analysis comparing LPHL and cHL patients. We found differences in FFTF and OS rates between both groups and differences in FFTF between LPHL stages. New treatment protocols for LPHL patients with reduced intensity schedules are to be discussed.
Double-Balloon Endoscopy in Crohn Disease: A Tertiary Referral Center Experience (2020)

We found that DBE is a safe and effective procedure in patients with suspected or established CD. Furthermore, patients undergoing dilation of strictures via DBE had an 80% surgery-free rate within the follow-up period.
Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors (2012)

Dynamic duo: The reversible reaction of boronic acids with alcohols to form boronate esters, coupled to protein mass spectrometry analyses, was used to discover potent oxygenase inhibitors. This dynamic combinatorial mass spectrometry technique could potentially be applied to the identification of other protein inhibitors.
In vivo spectral domain optical coherence tomography volumetric imaging and spectral Doppler velocimetry of early stage embryonic chicken heart development (2008)

Progress toward understanding embryonic heart development has been hampered by the inability to image embryonic heart structure and simultaneously measure blood flow dynamics in vivo. We have developed a spectral domain optical coherence tomography system for in vivo volumetric imaging of the chicken embryo heart. We have also developed a technique called spectral Doppler velocimetry (SDV) for quantitative measurement of blood flow dynamics. We present in vivo volume images of the embryonic heart from initial tube formation to development of endocardial cushions of the same embryo over several stages of development. SDV measurements reveal the influence of heart tube structure on blood flow dynamics.
Multiuser Correlation and Sum-Rate in Outdoor Measured Massive MIMO Channels (2020)

This letter analyzes the impact of interuser distance and angular separation on the channel correlation and achievable sum-rate for a massive multiple-input-multiple-output (MIMO) system in non-line-of-sight (NLOS) conditions. The investigation is based on outdoor measurements on a channel sounding system capturing the dynamic channel of two user arrays. The letter analyzes correlation and sum-rate with varying interuser distance and angular separation of dominant beams toward the users. A large span of correlation and sum-rate values are found across the range of distances and angular separation. The investigation shows a moderate link between interuser distance and correlation, but a strong impact on correlation is found only for low angular separation of the users. The results of this NLOS scenario suggest that a distance-based criteria alone is not sufficient to accurately model shared clusters and their correlation.
Low expression of CD20 and CD23 in Epstein-Barr virus-induced B cell tumors in SCID/hu mice. (1993)

Intraperitoneal injection of immunodeficient C.B.-17/scid (SCID) mice with human peripheral blood leukocytes from Epstein-Barr virus (EBV)-seropositive donors or with peripheral blood leukocytes from EBV-seronegative donors followed by an injection of EBV results in the development of human B-cell tumors. EBV-induced oligoclonal SCID/hu tumors closely resemble the EBV-associated lymphoproliferative disorders that are complications in immunosuppressed transplant patients. Previous reports have indicated that SCID/hu tumor cells are phenotypically similar to in vitro-transformed lymphoblastoid cell lines (LCL), which express high levels of mature B-cell lineage/activation antigens (CD19, CD20, CD21, CD23, CD30, CD39). In this study, however, flow cytometric (FACS) analysis showed that expression of CD20 and CD23 by SCID/hu tumor cells was markedly reduced relative to CD20 and CD23 expression by donor-matched, in vitro-transformed LCL. Injection of LCL into SCID mice also produced tumors in which CD20 and CD23 expression was greatly reduced relative to levels expressed by the injected LCL. In addition, tumorigenesis following LCL injection was associated with the production of high levels of human Ig in the sera of SCID mice. Our data thus indicate that EBV-driven tumorigenesis in vivo is associated with significant changes in B-cell phenotype relative to EBV-infected B cells transformed in vitro.
Decentralized Ciphertext-Policy Attribute-Based Encryption: A Post-Quantum Construction (2017)

In Ciphertext Policy Attribute-Based Encryption (CP-ABE) system, a set of attributes is associated with the private keys of each user. Also, the ciphertext is attached with a policy which is defined over that set of attributes. A user can decrypt the ciphertext if the ciphertext’s policy is satisfied by the attributes associated hith her private key. Traditional CP-ABE schemes, based on number theoretic problems, rely on a trustworthy central authority. But in many distributed applications it is expected that such authorities should be decentralized to avoid the risks of single-point failure. While the number theory-based hardness problems are prone to quantum attacks, lattice-based hardness problems can resist such attacks. In this paper, we construct a Decentralized Ciphertext-Policy Attribute-Based Encryption (DCP-ABE) scheme. Under this scheme, any participating entity can act as an authority by creating a public key. The athority utilizes the users’ attributes to generate the private keys for them. Any user can encrypt data in terms of any monotone access structure over attributes issued from any chosen set of authorities. Hence the protocol does not depend on any central authority. We utilize Learning With Errors over Rings (R-LWE) as the underlying hardness assumption for te protocol. The proposed post-quantum protocol achieves security under selective-set model whereby adversaries are allowed to corrupt any authority only statically through adaptive key queries.
Synthesis of Fluoroalkyl Sulfides via Additive-Free Hydrothiolation and Sequential Functionalization Reactions (2021)

A modular synthetic method, involving a hydrothiolation, silylation, and fluoroalkylation, for the construction of highly functionalized fluoroalkyl sulfides has been developed. The use of aprotic polar solvents enables the additive-free chemoselective hydrothiolation of tetrafluoroethylene, trifluorochloroethylene, and hexafluoropropene with various thiols. The stepwise functionalization reactions convert the hydrothiolated intermediates into the tetrafluoroethyl sulfides in high efficiency. The method avoids the use of the environmental pollutant Halon-2402, which was employed as a building block in a reported synthetic route.
Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease (2023)

White matter (WM) injury is frequently observed along with dementia. Positron emission tomography with amyloid-ligands (Aβ-PET) recently gained interest for detecting WM injury. Yet, little is understood about the origin of the altered Aβ-PET signal in WM regions. Here, we investigated the relative contributions of diffusion MRI-based microstructural alterations, including free water and tissue-specific properties, to Aβ-PET in WM and to cognition. We included a unique cohort of 115 participants covering the spectrum of low-to-severe white matter hyperintensity (WMH) burden and cognitively normal to dementia. We applied a bi-tensor diffusion-MRI model that differentiates between (i) the extracellular WM compartment (represented via free water), and (ii) the fiber-specific compartment (via free water-adjusted fractional anisotropy [FA]). We observed that, in regions of WMH, a decrease in Aβ-PET related most closely to higher free water and higher WMH volume. In contrast, in normal-appearing WM, an increase in Aβ-PET related more closely to higher cortical Aβ (together with lower free water-adjusted FA). In relation to cognitive impairment, we observed a closer relationship with higher free water than with either free water-adjusted FA or WM PET. Our findings support free water and Aβ-PET as markers of WM abnormalities in patients with mixed dementia, and contribute to a better understanding of processes giving rise to the WM PET signal.
Tilted Magnetic Levitation Enables Measurement of the Complete Range of Densities of Materials with Low Magnetic Permeability (2016)

Magnetic levitation (MagLev) of diamagnetic or weakly paramagnetic materials suspended in a paramagnetic solution in a magnetic field gradient provides a simple method to measure the density of small samples of solids or liquids. One major limitation of this method, thus far, has been an inability to measure or manipulate materials outside of a narrow range of densities (0.8 g/cm(3) < ρ < 2.3 g/cm(3)) that are close in density to the suspending, aqueous medium. This paper explores a simple method-"tilted MagLev"-to increase the range of densities that can be levitated magnetically. Tilting the MagLev device relative to the gravitational vector enables the magnetic force to be decreased (relative to the magnetic force) along the axis of measurement. This approach enables many practical measurements over the entire range of densities observed in matter at ambient conditions-from air bubbles (ρ ≈ 0) to osmium and iridium (ρ ≈ 23 g/cm(3)). The ability to levitate, simultaneously, objects with a broad range of different densities provides an operationally simple method that may find application to forensic science (e.g., for identifying the composition of miscellaneous objects or powders), industrial manufacturing (e.g., for quality control of parts), or resource-limited settings (e.g., for identifying and separating small particles of metals and alloys).
Unexpected Pyramid Texturization of n-Type Ge (100) via Electrochemical Etching: Bridging Surface Chemistry and Morphology (2018)

We report on the (electro) chemical etching behavior, surface morphology and composition of n-type Ge (100) in acidic halide solutions using various analytical and spectroscopic techniques. The use of an integrated (electro) chemical etching chamber connected to X-ray photoelectron spectroscopy instrument to exclude the effect of oxygen from atmosphere is highlighted.
Update on endovascular management of infrarenal abdominal aortic aneurysms in 2010; what has come and gone. (2010)

The past few decades have seen a very rapid change in the manner in which infrarenal aortic disease is diagnosed and dealt with. The approach has changed from open, large incision surgery with long and complicated postoperative courses to minimally invasive techniques in which the patient can go home the next day. A large number of devices have come and gone, and techniques to deal with aortic problems are ever changing. We have reviewed the past, current, and future technology to help make the treatment options more clear.
Kinetics of amphiphilic ketone epimerizations in cleavable surfactant hosts (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of amphiphilic ketone epimerizations in cleavable surfactant hostsDavid A. Jaeger, Phillip K. Chou, Durgadas. Bolikal, Dong. Ok, Kwang Yoo. Kim, Jeffrey B. Huff, Eun. Yi, and Ned A. PorterCite this: J. Am. Chem. Soc. 1988, 110, 15, 5123–5129Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://pubs.acs.org/doi/10.1021/ja00223a035https://doi.org/10.1021/ja00223a035research-articleACS PublicationsRequest reuse permissionsArticle Views193Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Separating ISI and CCI in a two-step FIR Bezout equalizer for MIMO systems of frequency-selective channels (2004)

The use of multiple antennas at both the transmitter and the receiver in wireless communications implies a great channel capacity, but the signal detection is a crucial problem in achieving channel capacity, particularly in the general case of frequency selective channels, where both intersymbol interference (ISI) and cochannel interference (CCI) are significant. We show that ISI and CCI can be separated and then be cancelled in two different steps. We develop a two-step FIR Bezout equalizer and deduce the theoretically smallest length of its equalization filter.