gebhart/patrepeval huggingface dataset:
Anatomic Distribution of Intravenously Injected IgG Takes Approximately 1 Week to Achieve Stratum Corneum Saturation in Vaginal Tissues (2021)

i.v. injected Abs have demonstrated protection against simian HIV infection in rhesus macaques, paving the way for the Antibody Mediated Prevention trial in which at-risk individuals for HIV received an i.v. infusion of the HIV broadly neutralizing Ab VRC01. However, the time needed for these Abs to fully distribute and elicit protection at mucosal sites is still unknown. In this study, we interrogate how long it takes for Abs to achieve peak anatomical levels at the vaginal surface following i.v. injection. Fluorescently labeled VRC01 and/or Gamunex-C were i.v. injected into 24 female rhesus macaques (<i>Macaca mulatta</i>) with vaginal tissues and plasma acquired up to 2 wk postinjection. We found that Ab delivery to the vaginal mucosa occurs in two phases. The first phase involves delivery to the submucosa, occurring within 24 h and persisting beyond 1 wk. The second phase is the delivery through the stratified squamous epithelium, needing ∼1 wk to saturate the stratum corneum. This study has important implications for the efficacy of immunoprophylaxis targeting pathogens at the mucosa.
Safety of repeated transplantations of neurotrophic factors‐secreting human mesenchymal stromal stem cells (2014)

Based on these results we conclude that repeated injections of human MSC-NTF are well tolerated in mice. The results of this study suggest that if the outcomes of additional clinical studies point to the need for repeated treatments, such option can be considered safe.
ChemInform Abstract: Palladium‐Catalyzed N‐Arylation of 2‐Aminothiazoles. (2012)

Abstract Optimized conditions are elaborated for the different types of substrates.
Practical total synthesis of (.+-.)-aklavinone and total synthesis of aklavin (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPractical total synthesis of (.+-.)-aklavinone and total synthesis of aklavinB. A. Pearlman, J. M. McNamara, I. Hasan, S. Hatakeyama, H. Sekizaki, and Y. KishiCite this: J. Am. Chem. Soc. 1981, 103, 14, 4248–4251Publication Date (Print):July 1, 1981Publication History Published online1 May 2002Published inissue 1 July 1981https://pubs.acs.org/doi/10.1021/ja00404a047https://doi.org/10.1021/ja00404a047research-articleACS PublicationsRequest reuse permissionsArticle Views790Altmetric-Citations86LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Differential Microstrip Antenna for RF Energy Harvesting (2015)

A differential microstrip antenna with improved gain for RF energy harvesting is presented in this paper. The developed antenna can be used in either center grounded or differential configuration. The antenna is designed and fabricated for GSM900 band (890-960 MHz). The antenna has a gain of 8.5 dBi at the center frequency and exhibits VSWR ≤ 2 for frequencies between 870 MHz to 1.05 GHz. The efficiency of the antenna is 80%. The developed antenna finds its application in energy harvesting, RFID tags and in wireless communication circuits, where differential inputs/outputs are needed. A complete differential RF energy harvesting system with a peak efficiency of 65.3% for a load of 3 kΩ is also developed.
Resistive Switching of Tetraaniline Films: From Ultrathin Monolayers to Robust Polymeric Blends (2013)

Oligomers of aniline and their derivatives have electrical and chemical properties that parallel those of polyaniline, while having the advantage of being available as homogeneous, chemically pure materials. Despite this advantage, little experimental data is available on the electrical transport properties of thin films of oligoanilines compared to polyaniline. Here, we investigate three types of ultrathin films (<50 nm thick) containing the emeraldine form of tetraaniline (TANI): self-assembled monolayers of the dithiocarbamate (DTC) derivative, spin-coated films of TANI, and spin-coated films of TANI/polymer blends. The electrical characteristics of these films, ranging in thickness from ∼1.4 nm (TANI-DTC monolayers), to ∼14 nm (neat TANI), to ∼40 nm (TANI/polymer blends), are obtained in junctions using Au and Hg-drop electrodes. High conductance on/off ratios between the emeraldine salt (on-state) and emeraldine base (off-state) are observed in all four systems (∼103–105 at V = +0.5 V), as demonstrated by exposing the as-prepared films to HCl vapor. Both the high electrical response toward acid doping and the mechanical robustness in TANI/polymer blends point toward oligoanilines as promising substitutes for polyaniline in next-generation molecular thin film devices.
Niobium superconducting rf cavity fabrication by electrohydraulic forming (2016)

Superconducting rf (SRF) cavities are traditionally fabricated from superconducting material sheets or made of copper coated with superconducting material, followed by trim machining and electron-beam welding. An alternative technique to traditional shaping methods, such as deep-drawing and spinning, is electrohydraulic forming (EHF). In EHF, half-cells are obtained through ultrahigh-speed deformation of blank sheets, using shockwaves induced in water by a pulsed electrical discharge. With respect to traditional methods, such a highly dynamic process can yield interesting results in terms of effectiveness, repeatability, final shape precision, higher formability, and reduced springback. In this paper, the first results of EHF on high purity niobium are presented and discussed. The simulations performed in order to master the multiphysics phenomena of EHF and to adjust its process parameters are presented. The microstructures of niobium half-cells produced by EHF and by spinning have been compared in terms of damage created in the material during the forming operation. The damage was assessed through hardness measurements, residual resistivity ratio (RRR) measurements, and electron backscattered diffraction analyses. It was found that EHF does not worsen the damage of the material during forming and instead, some areas of the half-cell have shown lower damage compared to spinning. Moreover, EHF is particularly advantageous to reduce the forming time, preserve roughness, and to meet the final required shape accuracy.
Ripple correlation control, with some applications (2003)

Ripple correlation control is a nonlinear control approach applicable to power electronic circuits. It makes use of voltage, current, or power ripple and correlates this with switching functions to effect control. The technique is especially well suited to power electronics because ripple is inherent, and can be treated as an internal perturbation. Ripple correlation control directly supports cost-function minimization and maximization. It can be applied, for example, to dynamic power optimization. It has been applied to adaptive dead time adjustment, solar power processing, and motor power minimization. Potential future applications include active maximization of converter efficiency and other nonlinear functions.
Robust approximate symmetric model predictive control (2015)

In this paper we study the explicit model predictive control (MPC) design for approximately symmetric systems. The approximately symmetric system is modeled as a symmetric system plus an additive disturbance residing in a symmetric set. The explicit MPC controller is computed using symmetry to minimize the number of critical regions stored in memory while being robust to model mismatch and disturbances. We show through numerical examples that approximating an approximately symmetric systems using a full symmetric system can drastically reduce memory usage and computation time for explicit controllers while still guaranteeing feasibility and input-to-state stability.
Chronic exposure to ammonia induces isoform‐selective alterations in the intracellular distribution and NMDA receptor‐mediated translocation of protein kinase C in cerebellar neurons in culture (2004)

Hyperammonemia is responsible for most neurological alterations in patients with hepatic encephalopathy by mechanisms that remain unclear. Hyperammonemia alters phosphorylation of neuronal protein kinase C (PKC) substrates and impairs NMDA receptor-associated signal transduction. The aim of this work was to analyse the effects of hyperammonemia on the amount and intracellular distribution of PKC isoforms and on translocation of each isoform induced by NMDA receptor activation in cerebellar neurons. Chronic hyperammonemia alters differentially the intracellular distribution of PKC isoforms. The amount of all isoforms (except PKC zeta) was reduced (17-50%) in the particulate fraction. The contents of alpha, beta1, and epsilon isoforms decreased similarly in cytosol (65-78%) and membranes (66-83%), whereas gamma, delta, and theta; isoforms increased in cytosol but decreased in membranes, and zeta isoform increased in membranes and decreased in cytosol. Chronic hyperammonemia also affects differentially NMDA-induced translocation of PKC isoforms. NMDA-induced translocation of PKC alpha and beta is prevented by ammonia, whereas PKC gamma, delta, epsilon, or theta; translocation is not affected. Inhibition of phospholipase C did not affect PKC alpha translocation but reduced significantly PKC gamma translocation, indicating that NMDA-induced translocation of PKC alpha is mediated by Ca2+, whereas PKC gamma translocation is mediated by diacylglycerol. Chronic hyperammonemia reduces Ca+2-mediated but not diacylglycerol-mediated translocation of PKC isoforms induced by NMDA.
Steering Reactive Force Model of Automobile with Steering Geometry (2004)

Steering reactive force of an automobile is a significant factor of human-automobile system. This paper describes an analysis model of steering reactive force on steady state cornering, which contains the information of steering geometry. In this model, forces and moments working on a wheel are formulated with direction cosine matrix, and variation of steering geometry are approximated with Euler rotation. Some running tests with a kart were carried out in order to evaluate characteristics of steering reactive force, and it was shown that the experimental results agree with the simulation results with proposed steering reactive force model.
A large-area curved pyroelectric fingerprint sensor (2019)

We show a thin, flexible and large 500 dpi fingerprint sensor for security applications providing better usability than existing sensors with a similar performance. A new process flow, using PVDF-TrFE pyroelectric capacitors on top of an IGZO TFT backplane on a flexible polyimide (PI) foil is implemented to create an active thermal fingerprint sensor. The system measurements fit well with the simulation of the thermal operation.
Numerical Simulations of the Partially Ionized Gas in a 100-A LaB<sub>6</sub> Hollow Cathode (2014)

Numerical simulations of a hollow cathode with a lanthanum hexaboride (LaB <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> ) emitter operating at 100 A have been performed using the 2-D Orificed Cathode (OrCa2D) code. Results for a variety of plasma properties are presented and compared with laboratory measurements. The large size of the device permits peak electron number densities in the cathode interior that are lower than those established in the NASA Solar Electric Propulsion Technology Application Readiness (NSTAR) hollow cathode, which operates at a 7.3× lower discharge current and 3.2× lower mass flow rate. The maximum electron current density also is lower in the LaB <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> cathode, by 4.2×, due to the larger orifice size. Simulations and direct measurements show that at 12 sccm of xenon flow the peak emitter temperature is in the range of 1630°C-1666°C. It is also found that the conditions for the excitement of current-driven streaming instabilities and ion-acoustic turbulence (IAT) are satisfied in this cathode, similarly to what was found in the past in its smaller counterparts like the NSTAR cathode. Based on numerical simulations, it has long been argued that these instabilities may be responsible for the anomalously large ion energies that have been measured in these discharges as well as for the enhancement of the plasma resistivity. Direct measurements of the turbulent spectra and confirmation of the presence of IAT in this cathode have now been completed. Interpolation of the measured anomalous collision frequency based on slightly different operating conditions than the one in the numerical simulations suggests good agreement with the computed values.
Abstract 10: Bundled Post-Conditioning Therapy Improves Hemodynamics and Post-Resuscitation Cardiac Function When Administered During the Metabolic Phase of Cardiac Arrest (2013)

Introduction: Effective therapies for the metabolic phase of cardiac arrest do not exist currently. We hypothesized that aggressively treating reperfusion injury using bundled therapy (BND) with ischemic post-conditioning (IPC) and sevoflurane plus Poloxamer 188 (P188) would improve resuscitation hemodynamics and reduce post-resuscitation LV dysfunction in a highly lethal model of prolonged cardiac arrest.

Methods: Following 15 min of VF, standard ACLS resuscitation was performed in control animals (N=8) and compared to animals that underwent 17 minutes of untreated VF followed by CPR augmented with BND (N=14), which consisted of (1) IPC: 20 seconds of chest compressions followed by a 20 second pause, repeated for a total for 3 cycles with (2) interval delivery of 2% sevoflurane breaths for 3 min, followed by (3) P188 (250 mg/kg) bolus administered IV with the same dose infused again over 4 hrs post ROSC. Both groups received 0.5 mg epinephrine prior to defibrillation. Systolic (SBP), diastolic (DBP) and right atrial pressure (RAP) were measured continuously and coronary perfusion pressure (CPP) calculated. In animals achieving ROSC, echocardiography was performed at 1 and 4 hrs to assess ejection fraction (EF). Unpaired t-tests were used for comparisons.

Results: SBP, DBP, and CPP were all significantly higher during BND resuscitation (Figure). EF following ROSC was higher in BND animals (63+13 at 1 hr, 61+8 at 4 hrs) vs controls (38+12 at 1 hr, 36+18 at 4 hrs) (p<0.001 for comparisons).

Conclusion: A strategy of bundled post-ischemic conditioning therapies improves hemodynamics during CPR and eliminates post-resuscitation LV dysfunction in this model.

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A New Look at Bacteriophage λ Genetic Networks (2006)

Bacteriophage λ is a temperate bacteriophage, meaning that it can reproduce and develop either in a lytic or lysogenic state. When λ infects its bacterial host Escherichia coli , the phage may develop lytically, causing cell lysis with the release of hundreds of progeny virus, or it may abort
Modulation of Pituitary Thyrotropin Releasing Hormone Receptor Levels by Estrogens and Thyroid Hormones (1977)

The effect of estradiol and thyroid hormone treatment on pituitary TRH binding and TSH and PRL responses to the neurohormone was studied. A significant increase in the number of pituitary TRH binding sites was observed between 2 and 4 days after daily administration of estradiol benzoate with a plateau at 300% of control being reached at 7 days. Plasma PRL levels showed a similar early pattern of response. In animals rendered hypothyroid by a 2-month treatment with propylthiouracil or 1 month after surgical thyroidectomy, the level of pituitary TRH receptors was increased approximately 2-fold, this elevation being completely reversed by treatment with thyroid hormone. Estradiol-17beta administered with L-thyroxine partially reversed the inhibitory effect of thyroid hormone on TRH receptor levels in hypothyroid animals. The antagonism between estrogens and thyroid hormone is also apparent on the TSH response to TRH since estrogen administration can reverse the marked inhibition by thyroxine of the TSH response to TRH either partially or completely in intact and hypothyroid animals, respectively. The PRL response to TRH is 55 and 40% inhibited in hypothyroid and intact rats, respectively, by thyroid hormone when combined with estrogen treatment. The present data clearly show that estrogens and thyroid hormones can affect TSH and PRL secretion, the effect of estrogens being predominantly on PRL secretion while thyroid hormone affects mainly TSH. The close correlation observed between the level of TRH receptors and PRL and TSH responses to TRH suggests that estrogens and, to a lesser extent, thyroid hormones, exert their action by modulation of the level of receptors for the neurohormone in both thyrotrophs and mammotrophs.
High-quality draft genome sequence of a biofilm forming lignocellulolytic Aspergillus niger strain ATCC 10864 (2017)

Filamentous fungus <i>Aspergillus niger</i> has high industrial value due to their lignocellulolytic enzyme activities and ATCC 10864 is one of the few type strains of <i>A. niger</i> which has a unique biofilm forming capability. Here we report the first draft genome sequence of <i>A. niger</i> ATCC 10864 strain. The genome of <i>A. niger</i> ATCC 10864 is 36,172,237 bp long and comprise of 310 scaffolds with 49.5% average GC content. A total of 10,804 protein-coding genes were predicted among which 10,761 genes were with putative functions. <i>A. niger</i> ATCC 10864 genome coded for 709 putative carbohydrate active enzyme families distributed in six functional categories and among them glycoside hydrolases (GHs) represent the most number of families (279). Genes that include <i>pepA</i>, <i>brlA</i>, <i>exgA</i>, <i>LaeA</i>, <i>rodA</i>, <i>GCN</i> have also been identified in this study, which may play a role in biofilm formation. This high-quality draft genome sequence will facilitate our understanding of the mechanisms behind fungal biofilm formation and higher lignocellulolytic enzyme production.
Synthesis, Structure, and Properties of a Tetrametallic Ferrocenecarboxylato-Bridged Copper(II) Complex (1998)

The first tetrametallic compound containing a [Cu2{μ-O2C[(η5-C5H4)Fe(η5-C5H5)]}2]2+ core is synthesized. X-ray analysis shows π-stacking interactions between the terminal bidentate 2,2‘-bipyridine ligands. Magnetic and electrochemical properties are reported.
Coronary Artery Spasm-Related Heart Failure Syndrome: Literature Review (2023)

Although heart failure (HF) is a clinical syndrome that becomes worse over time, certain cases can be reversed with appropriate treatments. While coronary artery spasm (CAS) is still underappreciated and may be misdiagnosed, ischemia due to coronary artery disease and CAS is becoming the single most frequent cause of HF worldwide. CAS could lead to syncope, HF, arrhythmias, and myocardial ischemic syndromes such as asymptomatic ischemia, rest and/or effort angina, myocardial infarction, and sudden death. Albeit the clinical significance of asymptomatic CAS has been undervalued, affected individuals compared with those with classic Heberden's angina pectoris are at higher risk of syncope, life-threatening arrhythmias, and sudden death. As a result, a prompt diagnosis implements appropriate treatment strategies, which have significant life-changing consequences to prevent CAS-related complications, such as HF. Although an accurate diagnosis depends mainly on coronary angiography and provocative testing, clinical characteristics may help decision-making. Because the majority of CAS-related HF (CASHF) patients present with less severe phenotypes than overt HF, it underscores the importance of understanding risk factors correlated with CAS to prevent the future burden of HF. This narrative literature review summarises and discusses separately the epidemiology, clinical features, pathophysiology, and management of patients with CASHF.
E Antigen: A Cell-Surface Antigen of C57BL Leukemias (1970)

SUMMARY Antisera were prepared in (C3H/An X !)F! mice against a transplanted leukemia (E9SL2) that had arisen spontaneously in C57BL/6 mice. After removal of cytotoxic antibodies to normal alloantigens by absorption in vivo in C57BL/6 mice, the antisera detected an antigen, designated E, which is distinct from the four previously recognized cell-surface antigens (G, FMR, TL, and ML) associated with mouse leukemias. E antigen was detected on two other spontaneous leukemias of C57BL/6 origin and on the long-transplanted chemically induced leukemia, EL4. It was not found on any normal C57BL/6 tissues nor on radiation-induced or on virus-induced (Gross, Moloney, Rauscher) C57BL/6 leukemias. Thirty-nine solid tumors and leukemias from strains other than C57BL/6 lack E antigen. By the indirect immunoferritin technique, E antigen was seen to occupy discrete patches on the surface of E+ leukemia cells. Murine leukemia virus (type C or enveloped A) was not observed in E+ leukemias. Intracisternal A particles were present, but, as these are found also in Eâ€”leukemias and solid tumors, it is unlikely that they are related to E antigen. Thus, the origin of E antigen, whether from cellular genes or from viral genes, is unknown.
Excitation of discrete X-waves in nonlinear waveguide arrays (2006)

We present experimental evidence for the formation of X-waves in nonlinear AlGaAs waveguide arrays. These results agree with numerical simulations based on the discrete nonlinear Schrodinger equation with an appropriate temporal dispersion term
Phase II Clinical Research Design in Cardiology (2013)

clinical trials; phase II; research design; stem cell; therapy Clinical trials demonstrate the best of medical expertise and epidemiological elegance.From the simple building blocks of contemporaneous control groups, randomization, and blinding, they assemble a clear picture of the nature of the treatment-effect relationship.This accomplishment has earned them the star ascendant position in cardiovascular research.
Cardiac Imaging: Part 2, Normal, Variant, and Anomalous Configurations of the Coronary Vasculature (2011)

The coronary arteries generally are predictable in their origin, course, and perfusion territories. Standardized reporting systems exist for describing the location of specific lesions, and radiologists who interpret CT and MR coronary images should be aware of and should attempt to integrate these reporting schemes into clinical practice.
Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-α Cre-Mediated Neuropilin-1 Null Mice (2015)

Our findings provide new insights into the cardioprotective role of NRP-1 and its influence on global metabolism.