gebhart/patrepeval huggingface dataset:
A 1V buck converter IC with hybrid current-mode control and a charge-pump DAC (2008)

This paper presents an integrated dc-dc converter with an output voltage of 1 V for portable applications. A hybrid peak current-mode control-scheme is demonstrated, where the voltage-loop compensation is achieved in the digital domain, while the current-regulation loop has a more traditional analog implementation. The main contribution of this work is the novel DAC architecture, which was developed specifically to achieve fast transient-response without needing clock frequencies beyond f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</sub> , or expensive signal processing. Unlike the previous approach, based on an adaptive DeltaSigma DAC, the charge-pump (CP) DAC is capable of rapidly increasing the current-command in a single-cycle during load-steps. In addition to a low steady-state current-consumption of 3 muA, the CP-DAC has a guaranteed monotonic transfer characteristic and simplifies the overall system architecture. The resulting system solution achieves dynamic response comparable to state-of-the-art analog current-mode solutions, without using a power-hungry controller, or quantizing the inductor current. A custom IC, which was fabricated in a 0.18 mum CMOS process with 5 V compatible transistors, achieves a response-time of 4 mus at f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</sub> = 3 MHz and V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">out</sub> = 1 V, for a 200 mA load-step. The active area of the controller is only 0.077 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , and the total controller current-draw, which is heavily dominated by the on-chip senseFET current-sensor, is below 0.5 % of the load current at I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">out</sub> = 50 mA.
Heterologous carotenoid production in Saccharomyces cerevisiae induces the pleiotropic drug resistance stress response (2010)

To obtain insight into the genome-wide transcriptional response of heterologous carotenoid production in Saccharomyces cerevisiae, the transcriptome of two different S. cerevisiae strains overexpressing carotenogenic genes from the yeast Xanthophyllomyces dendrorhous grown in carbon-limited chemostat cultures was analysed. The strains exhibited different absolute carotenoid levels as well as different intermediate profiles. These discrepancies were further sustained by the difference of the transcriptional response exhibited by the two strains. Transcriptome analysis of the strain producing high carotenoid levels resulted in specific induction of genes involved in pleiotropic drug resistance (PDR). These genes encode ABC-type and major facilitator transporters which are reported to be involved in secretion of toxic compounds out of cells. β-Carotene was found to be secreted when sunflower oil was added to the medium of S. cerevisiae cells producing high levels of carotenoids, which was not observed when added to X. dendrorhous cells. Deletion of pdr10, one of the induced ABC transporters, decreased the transformation efficiency of a plasmid containing carotenogenic genes. The few transformants that were obtained had decreased growth rates and lower carotenoid production levels compared to a pdr5 deletion and a reference strain transformed with the same genes. Our results suggest that production of high amounts of carotenoids in S. cerevisiae leads to membrane stress, in which Pdr10 might play an important role, and a cellular response to secrete carotenoids out of the cell.
A role for human Dicer in pre-RISC loading of siRNAs (2010)

RNA interference is a powerful mechanism for sequence-specific inhibition of gene expression. It is widely known that small interfering RNAs (siRNAs) targeting the same region of a target-messenger RNA can have widely different efficacies. In efforts to better understand the siRNA features that influence knockdown efficiency, we analyzed siRNA interactions with a high-molecular weight complex in whole cell extracts prepared from two different cell lines. Using biochemical tools to study the nature of the complex, our results demonstrate that the primary siRNA-binding protein in the whole cell extracts is Dicer. We find that Dicer is capable of discriminating highly functional versus poorly functional siRNAs by recognizing the presence of 2-nt 3' overhangs and the thermodynamic properties of 2-4 bp on both ends of effective siRNAs. Our results suggest a role for Dicer in pre-selection of effective siRNAs for handoff to Ago2. This initial selection is reflective of the overall silencing potential of an siRNA.
Mixed Preformed Particle Gel System for Water Shutoff in Fractured Carbonate Reservoir (2023)

Abstract Water shutoff from production well using particle type material is a great challenge due to the complex pressure and flow distributions near wellbore. A mixed preformed particle gel (PPG) system was developed to enhance the performance for water shutoff in fractured carbonate reservoirs. The PPG blocking behaviors in fractures and methods to improve the water flush tolerance were investigated. PPG strength dominated the water shutoff performances in fractures. PPG with medium to high strength showed better performance than other samples due to the well-adjusted properties in blocking and flush tolerance. For the selected PPG, 30 mesh sample showed the best blocking performance among single mesh samples from 20 mesh to 80 mesh in the fractured artificial metal plug. Using 30 mesh sample as base sample, the 30 mesh and 40 mesh mixture with weight ratio 2:1 produced highest pressure build-up in two-size PPG mixtures. Further increasing the particle size distribution by combining various particle size PPGs, the blocking performance was improved. An optimized combination of 30 mesh, 40 mesh, 50 mesh and 60 mesh particles with weigh ratio of 4:2:1:0.25 was developed. In addition, a fiber material, added in the PPG, significantly improved the water flush tolerance of the PPG pack. A particle size combination of PPGs mixed with the fiber material generated better blocking performances than the other combinations. This study provides insights on packing behavior of deformable gel particles in fractures with a practical PPG based system for water shutoff treatments.
Experimental evaluation of charge laws for road vehicle batteries (2002)

The efficiency of electric road vehicles is heavily dependent on electrochemical battery characteristics and performance. In the paper, charge and recharge laws are analysed by means of a model of a battery that is proposed to represent the battery behaviour. In the paper are presented some experimental results, in order to evaluate the battery's ability to recover energy during braking operation. The proposed model is validated through tests realized on a workbench which has been constructed in the Laboratory of the University of Naples. The main characteristics of the workbench are evidenced in the paper. Experimental data coming from testing procedures realized by the University of Naples are analysed and compared to data collected on the road during the activity done within the ATENA Research Project.
Haemophilus influenzae Type a Infection and Its Prevention (2007)

Haemophilus influenzae was first described by Pfeiffer in 1892 ([30][1]). Forty years later Pittman identified six capsular polysaccharides (types) of H. influenzae (a, b, c, d, e, and f) whose structures were later elucidated (Table [1][2]) ([12][3], [31][4], [40][5]). Systemic infections in
Measuring Fiber Length in the Core and Shell Regions of Injection Molded Long Fiber-Reinforced Thermoplastic Plaques (2020)

Long fiber-reinforced thermoplastics are an attractive design option for many industries due to their excellent mechanical properties and processability. Processing of these materials has a significant influence on their microstructure, which controls the properties of the final part. The microstructure is characterized by the fibers’ orientation, length, and concentration. Many characterization methods can capture the fiber orientation and concentration changes through the thickness in injection molded parts, but not the changes in fiber length. In this study, a technique for measuring fiber length in the core and shell regions of molded parts was proposed, experimentally verified, and used on injection molded 20 wt.% glass fiber-reinforced polypropylene plaques. The measured fiber length in the core was 50% higher than in the shell region. Comparison with simulation results shows disagreement in the shape of the through-thickness fiber length profile. Stiffness predictions show that the through-thickness changes in fiber length have little impact on the longitudinal and transverse Young’s modulus.
Evaluation of Arylimidamides DB1955 and DB1960 as Candidates against Visceral Leishmaniasis and Chagas' Disease: In Vivo Efficacy, Acute Toxicity, Pharmacokinetics, and Toxicology Studies (2012)

Arylimidamides (AIAs) have shown outstanding in vitro potency against intracellular kinetoplastid parasites, and the AIA 2,5-bis[2-(2-propoxy)-4-(2-pyridylimino)aminophenyl]furan dihydrochloride (DB766) displayed good in vivo efficacy in rodent models of visceral leishmaniasis (VL) and Chagas' disease. In an attempt to further increase the solubility and in vivo antikinetoplastid potential of DB766, the mesylate salt of this compound and that of the closely related AIA 2,5-bis[2-(2-cyclopentyloxy)-4-(2-pyridylimino)aminophenyl]furan hydrochloride (DB1852) were prepared. These two mesylate salts, designated DB1960 and DB1955, respectively, exhibited dose-dependent activity in the murine model of VL, with DB1960 inhibiting liver parasitemia by 51% at an oral dose of 100 mg/kg/day × 5 and DB1955 reducing liver parasitemia by 57% when given by the same dosing regimen. In a murine Trypanosoma cruzi infection model, DB1960 decreased the peak parasitemia levels that occurred at 8 days postinfection by 46% when given orally at 100 mg/kg/day × 5, while DB1955 had no effect on peak parasitemia levels when administered by the same dosing regimen. Distribution studies revealed that these compounds accumulated to micromolar levels in the liver, spleen, and kidneys but to a lesser extent in the heart, brain, and plasma. A 5-day repeat-dose toxicology study with DB1960 and DB1955 was also conducted with female BALB/c mice, with the compounds administered orally at 100, 200, and 500 mg/kg/day. In the high-dose groups, DB1960 caused changes in serum chemistry, with statistically significant increases in serum blood urea nitrogen, lactate dehydrogenase, aspartate aminotransferase, and alanine aminotransferase levels, and a 21% decrease in body weight was observed in this group. These changes were consistent with microscopic findings in the livers and kidneys of the treated animals. The incidences of observed clinical signs (hunched posture, tachypnea, tremors, and ruffled fur) were more frequent in DB1960-treated groups than in those treated with DB1955. However, histopathological examination of tissue samples indicated that both compounds had adverse effects at all dose levels.
State of the Art Assessment of Simulation in Advanced Materials Development (2008)

Advances in both the underlying theory and in the practical implementation of molecular modeling techniques have increased their value in the advanced materials development process. The objective is to accelerate the maturation of emerging materials by tightly integrating modeling with the other critical processes: synthesis, processing, and characterization. The aims of this report are to summarize the state of the art of existing modeling tools and to highlight a number of areas in which additional development is required. In an effort to maintain focus and limit length, this survey is restricted to classical simulation techniques including molecular dynamics and Monte Carlo simulations.
A practical synthesis of a novel PPAR alpha agonist (2010)

An efficient synthesis of a potent PPAR alpha (peroxisome proliferator-activated receptors) agonist is described.The key step in the synthesis is a palladium-catalyzed coupling reaction between a suitably substituted benzene and the anion of methyl isobutyrate.Amide formation with proline provided the drug substance in 62% overall yield based on 2.
CMOS micromechanical resonator oscillator (2002)

A completely monolithic high-Q oscillator, fabricated via a combined CMOS plus surface micromachining technology, is described, for which the oscillation frequency is controlled by a polysilicon micromechanical resonator to achieve stability and phase noise performance comparable to those of quartz crystal oscillators. It is shown that the closed-loop, steady-state oscillation amplitude of this oscillator can be controlled through the DC-bias voltage applied to the capacitively driven and sensed /spl mu/resonator. Measurements indicate a phase noise density level of -168 dBm/Hz at 5 kHz offset frequency for an oscillator carrier power of -14.5 dBm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Novel circular antenna with elliptical rings for ultra-wide-band (2016)

This Novel antenna consists mainly of conducting Circular patch with elliptical rings and partial conducting ground plane, with dimensions of 45 mm×31 mm×1.27 mm, Rogers 5880 LZ is selected as a substrate. The impedance bandwidth of the designed antenna is between 3.5 GHz to 9 GHz. The selected partial ground length is 11 mm. VSWR and S11 are obtained for the new antenna through HFSS simulation for different ground plane lengths. Antenna group delay, maximum antenna gain and radiation pattern for this novel antenna are studied and analyzed. The presented antenna achieved the desired BW and the simulated S11 and VSWR are coherent and show unique performance.
738. Towards Gene Correction of X-Linked SCID Using Engineered Zinc Finger Nucleases and Integrase Defective Lentiviral Delivery (2006)

X-linked severe combined immunodeficiency (X-SCID), a fatal disorder caused by mutations in the IL2Rγ gene, has been treated by retroviral vector (RV) mediated gene replacement in hematopoietic stem cells (HSC). A crucial factor for the success of this approach was the selective growth advantage of gene-modified cells, which allowed lymphoid repopulation from a small number of transduced HSC. Unfortunately, leukemia developed in a fraction of treated patients and its origin was linked to RV insertional mutagenesis. An alternative approach to gene replacement is correction of the endogenous gene using engineered zinc finger protein-based nucleases (ZFNs) to specifically target a DNA double stranded break at the mutation site. One mechanism the cell uses to repair these breaks is homologous recombination (HR), and specific nucleotide substitution can be made in the genome by delivering an extrachromosomal donor molecule to serve as repair template during HR. By the combined delivery of cognate ZFNs and template DNA, mutations may be corrected and normal gene function restored. Although this only occurs in a fraction of treated cells, selection of corrected cells may allow successful exploitation of this new technology for gene therapy. Moreover, because gene correction stably restores both gene function and its normal regulation, it overcomes the limitations of integrative gene replacement and its possible adverse effects. However, for gene therapy applications, both ZFNs and donor DNA must be delivered into target cells with high efficiency and without perturbing their function, a challenge for gene transfer technologies. We have developed a delivery platform based on integrase-defective lentiviral vectors (IDLV), which takes advantage of the viral proficiency to both introduce donor DNA and transiently express ZFNs in the same cell. By using this approach in model cell lines, we achieved levels of gene correction that were higher than those observed with plasmid-based delivery. These vectors were further enhanced by optimizing the ZFN expression cassette and combining them with the donor DNA in the same vector. Remarkably, when these vectors targeting a mutation hotspot in the IL2Rγ gene were transduced into hematopoietic cell lines, we found up to 40% editing of the endogenous IL2Rγ gene. Importantly, HR with the donor vector accounted for 75% of the total editing. We then transduced a panel of immortalized B-lymphocytes from both normal donors and X-SCID patients. When the treated cells were analyzed for genome editing, we found up to 8% HR in the IL2Rγ locus. We are currently following-up these studies to assess functional restoration of IL2R signalling in patient cells, and extending the application of IDLV-ZFN mediated gene editing to human HSC. Our results provide proof of principle of a new gene delivery strategy reaching an unprecedented frequency of targeted gene correction and potentially improving efficacy and safety of gene therapy. Sangamo own ZFN technology and is developing its application.
Inflammation‐inducible anti‐TNF gene expression mediated by intra‐articular injection of serotype 5 adeno‐associated virus reduces arthritis (2007)

These findings strongly support the feasibility of improving the safety of anti-TNF approaches for the treatment of arthritis by local rAAV5-mediated gene expression under an inflammation-responsive promoter, able to provide a limited, transient and therapeutically relevant expression of anti-TNF compounds.
Perkin 1 Abstracts: Natural Product Synthesis (2000)

R. Narquizian, J. Milne and D. McAurthur, J. Chem. Soc., Perkin Trans. 1, 2000, 12-ix DOI: 10.1039/B003116J
Joint transmit/ receive IQ compensation for OFDM-based communication systems (2007)

info:eu-repo/semantics/published
Dynamic Hemodialysis: A Potential Solution for Middle Molecule Removal (2011)

Better clearance of middle molecular weight solutes has been associated with improved patient outcomes. However, blood-membrane interaction during dialysis results in the development of secondary protein layers on the dialysis membrane surface, leading to impairments in middle molecular weight solute removal. The shear rate at the surface of the dialysis membrane is one of the important factors that influence blood-membrane surface interaction. In this paper, we discuss the concept of 'dynamic hemodialysis', i.e. using mechanical vibration to increase shear rate at the surface of dialysis membrane. For longitudinal and transverse vibratory motions, hemodynamic changes inside the membrane and their consequent effects on membrane morphology and dialysis efficiency are discussed. Longitudinal vibration generates a reverse flow by relative membrane motion, and transverse vibration generates a symmetric swirling flow inside the hollow fiber, which increases shear rate and enhances flow mixing. Additionally, the impulse induced by the vibration could sustain the absorption capacity of the membrane to specific uremic toxins. In conclusion, dynamic hemodialysis could enhance solute removal by minimizing the morphological changes in the dialysis membrane during hemodialysis. However, the operating conditions of dynamic hemodialysis (i.e. the amplitude and frequency of mechanical vibration) need to be optimized in terms of hemolysis and noise from the mechanical vibration.
Raman Submicron Spatial Mapping of Individual Mn-doped ZnO Nanorods (2017)

ZnO nanorods (NRs) arrays doped with a large concentration of Mn synthesized by aqueous chemical growth and were characterized by SEM, photoluminescence, Raman scattering, magnetic force microscopy (MFM). By comparison of spectra taken on pure and Mn-doped ZnO NRs, a few new Raman impurity-related phonon modes, resulting from the presence of Mn in the investigated samples. We also present a vibrational and magnetic characterization of individual lying nanorods using Raman and MFM imaging. Confocal scanning micro-Raman mapping of the spatial distribution of intensity and frequency of phonon modes in single Mn-doped ZnO NRs nanorods is presented and analyzed for the first time. Mn-related local vibrational modes are also registered in Raman spectra of the single nanorod, confirming the incorporation of Mn into the ZnO host matrix. At higher Mn concentration the structural transformation toward the spinel phase ZnMn<sub>2</sub>O<sub>4</sub> and Mn3O4 is observed mainly in 2D bottom layers. MFM images of Mn-doped ZnO NR arrays and single nanorod were studied in nanoscale at room temperature and demonstrate magnetic behavior. The circular domain magnetic pattern on top of single nanorod originated to superposition of some separate domains inside rod. This demonstrates that long-range ferromagnetic order is present at room temperature. Aligned Mn-doped ZnO NRs demonstrates that long-range ferromagnetic order and may be applied to future spintronic applications.
Effect of Dielectric Barrier Discharge Plasma on the Attachment and Proliferation of Osteoblasts Cultured over Poly(ε‐caprolactone) Scaffolds (2008)

DOI: 10.1002/ppap.200700041 The author would like to announce the following corrections: Gary Friedman has been included as co-author into the author list. The authors apologize for any inconvenience caused.
Axial-Loading Circumferential Dovetail Turbine-Blade Mount (1992)

In new configuration, retaining ring holds base of blades in circumferential dovetail slot. Blades inserted axially via loading slots into circumferential dovetail slot. Ring placed over loading slots and fastened with split ring held by arm of disk. Blades less likely to be shaken loose during operation.
Oxygen Isotopic Compositions of Asteroidal Materials Returned from Itokawa by the Hayabusa Mission (2011)

Meteorite studies suggest that each solar system object has a unique oxygen isotopic composition. Chondrites, the most primitive of meteorites, have been believed to be derived from asteroids, but oxygen isotopic compositions of asteroids themselves have not been established. We measured, using secondary ion mass spectrometry, oxygen isotopic compositions of rock particles from asteroid 25143 Itokawa returned by the Hayabusa spacecraft. Compositions of the particles are depleted in (16)O relative to terrestrial materials and indicate that Itokawa, an S-type asteroid, is one of the sources of the LL or L group of equilibrated ordinary chondrites. This is a direct oxygen-isotope link between chondrites and their parent asteroid.
The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli (2020)

Although arterial and venous thromboembolic disorders are among the most frequent causes of mortality and morbidity, there has been little description of how the composition of thrombi and emboli depends on their vascular origin and age. We quantified the structure and composition of arterial and venous thrombi and pulmonary emboli using high-resolution scanning electron microscopy. Arterial thrombi contained a surprisingly large amount of fibrin, in addition to platelets. The composition of pulmonary emboli mirrored the most distal part of venous thrombi from which they originated, which differed from the structure of the body and head of the same thrombi. All thrombi and emboli contained few biconcave red blood cells but many polyhedrocytes or related forms of compressed red blood cells, demonstrating that these structures are a signature of clot contraction in vivo. Polyhedrocytes and intermediate forms comprised the major constituents of venous thrombi and pulmonary emboli. The structures within all of the thrombi and emboli were very tightly packed, in contrast to clots formed in vitro. There are distinctive, reproducible differences among arterial and venous thrombi and emboli related to their origin, destination and duration, which may have clinical implications for the understanding and treatment of thrombotic disorders.