gebhart/patrepeval huggingface dataset:
Resistance to Phytophthora infestans in Lycopersicon pennellii (2007)

To determine if the desert tomato, Lycopersicon pennellii, possesses resistance to late blight, caused by Phytophthora infestans, two plant populations were analyzed. Resistance was identified through assessments of disease progress in an F2 mapping population (L. esculentum × L. pennellii) and in a series of introgression lines (L. pennellii into L. esculentum). Levels of resistance varied widely among individuals within each population. However, the response of individuals to different strains of P. infestans was consistent. In the mapping population, a quantitative trait locus (QTL) was detected near marker T1556 on chromosome 6. This QTL accounted for 25% of the phenotypic variance in the population. The occurrence of this QTL was confirmed from analysis of the introgression lines (ILs), where IL 6-2 (containing marker T1556) was the most resistant IL in 2002 and the second most resistant IL in 2001. The identification of an additional QTL for resistance to late blight in tomato will aid in the development of durable resistance to this devastating disease.
SPC2968—A novel Hif-1α antagonist for treatment of clear cell renal cell carcinoma (2006)

14581 Background: SPC2968 is a short (16-mer), oligonucleotide antagonist of Hif-1α mRNA in which potency has been enhanced through incorporation of Locked Nucleic Acid. Over-expression of Hif-1α has been correlated with increased vascularisation, metastatic potential and poor clinical outcome in a variety of malignancies, including Renal Cell Carcinoma (RCC) of clear cell aetiology, where Hif-1α dysregulation, brought about by mutations in the von Hippel Lindau gene, appears to play a major pathogenic role. Methods: In vitro, human cancer and endothelial cells grown under hypoxic conditions were used to evaluate the effect of SPC2968 on mRNA and protein to Hif-1α as well as phenotypic effects, measured by quantitative polymerase chain reaction (QPCR), Western blotting and biochemical/cellular assays. QPCR was also used to measure mRNA levels in SPC2968-treated mice, while the effects of the drug on tumour growth and vascularisation were evaluated in xenografts. To assess biodistribution in vivo, tritium-labelled SPC2968 was injected intravenously. Results: In vitro, SPC2968 at 1nM reduced both mRNA and protein levels of Hif-1α in cancer cell lines and downregulated two downstream targets of Hif-1, VEGF and MMP-2.Treatment also induced apoptosis in tumour cells and prevented tube formation by endothelial cells in vitro. Parenteral administration of SPC2968 in mice yielded potent inhibition of Hif-1α and VEGF mRNA in several tissues, including kidney, liver, and colon. Radioactively labelled SPC2968 distributed to kidney, liver, colon, bone marrow, lymph nodes and skin. Preclinical studies investigating acute and sub-acute toxicity and safety pharmacology of SPC2968 are completed, and SPC2968 was well tolerated. Conclusions: SPC2968 is an effective suppressor of Hif-1α mRNA and Hif-1α-regulated genes in vitro and in vivo and has shown good tissue biostability and biodistribution in rodents. Preclinical safety studies have been completed, and SPC2968 is ready for clinical testing. A phase I/II, dose-escalating study of SPC2968 in clear cell RCC in the US and the EU is planned to be submitted by mid 2006. [Table: see text]
Frequency-Reconfigurable Optical-to-Radio Signal Converter Based on Radio-over-Fiber Technology with Optical Frequency Comb (2013)

A frequency-reconfigurable radio-over-fiber (RoF) signal convertor based on an optical frequency comb is proposed for application to a millimeter-wave/terahertz/optical hybrid system. The frequency transition from the RoF signal at 83 GHz to the higher millimeter-wave and terahertz signals is successfully demonstrated.
An Initial Report on a Comprehensive, Quantitative, Screening Procedure For Volatile Compounds of Forensic and Evnironmental Interest in Human Biofluids by GC/MS (1979)

This report deals with the establishment of a comprehensive screening procedure, employing a headspace concentration technique for sample preparation and gas chromatography-mass spectrometry for detection and measurement of trapped volatile and gaseous components. An evaluation of the methodology revealed that up to thirty different gaseous and volatile toxic substances may be isolated from biospecimens and measured using this system at concentrations approaching the part per million level. Identification of a particular gas or volatile substance is accomplished by use of extracted ion profiles. Quantitation is achieved by use of the specific ion current measurement of the major component ion, modified by the corresponding ion current of a simultaneously run internal standard. Precision at either end of the chromatographic run is maintained by use of two internal standards (early versus late eluting). Data regarding extracted ion methodology, retention time estimates, and precision estimates for various commonly encountered volatile and gaseous substances are presented.
Supplementary Figure 4 from Proteasome Inhibition Causes Regression of Leukemia and Abrogates BCR-ABL–Induced Evasion of Apoptosis in Part through Regulation of Forkhead Tumor Suppressors (2023)

Supplementary Figure 4 from Proteasome Inhibition Causes Regression of Leukemia and Abrogates BCR-ABL–Induced Evasion of Apoptosis in Part through Regulation of Forkhead Tumor Suppressors
Cobalt‐Mediated Cyclotrimerization of Bis‐alkynes and Cyanamides. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
The Pierre Auger Observatory IV: Operation and Monitoring (2011)

Abstract Not Provided
Search for displaced vertices arising from decays of new heavy particles in 7 TeV pp collisions at ATLAS (2011)

We present the results of a search for new, heavy particles that decay at a significant distance from their production point into a final state containing charged hadrons in association with a high-momentum muon. The search is conducted in a pp-collision data sample with a center-of-mass energy of 7 TeV and an integrated luminosity of 33 pb−1 collected in 2010 by the ATLAS detector operating at the Large Hadron Collider. Production of such particles is expected in various scenarios of physics beyond the standard model. We observe no signal and place limits on the production cross-section of supersymmetric particles in an R-parity-violating scenario as a function of the neutralino lifetime. Limits are presented for different squark and neutralino masses, enabling extension of the limits to a variety of other models.
Evaluation of the CELL-DYN 3000 Differential (1992)

The CELL-DYN 3000 (Unipath Corp., Mountain View, CA) differential was evaluated in a tertiary care hospital using samples with a broad range of distributional and morphologic abnormalities. Particular attention was directed to the performance of the instrument-generated suspect flags that occur as an aid to identify samples with abnormal leukocytes, as well as the estimates of abnormal cells that are made by the instrument. The CELL-DYN 3000 showed excellent quantitative results for the white blood cell differential compared with a 400-cell manual differential, in which morphologic abnormalities were absent or occurred in low numbers (< or = 5%). Specificity of the BLAST, VARIANT LYMPH, NRBC, WBC, or DIFF suspect flags (with the requirement that the blast estimate and variant lymphocyte estimate by the instrument be > or = 1%) was 82.6%. Sensitivity of these flags to detection of more than 5% "abnormal" leukocytes (blasts, malignant lymphoid cells, grossly dysplastic neutrophils, nucleated red blood cells, or reactive lymphocytes) or significant platelet clumping was 81.6%. The primary deficiency was the inability of the CELL-DYN 3000 to flag samples with small numbers (< or = 5%) of nucleated erythrocytes, lymphoid blasts, or hairy cells, or more than 5% reactive lymphocytes. Specificity of the IG flag (with immature granulocyte estimate > or = 3%) for immature granulocytes (metamyelocytes, myelocytes, or promyelocytes) was 94.9%. Sensitivity of the immature granulocyte flag varied from 41.7% for identifying IG > or = 1% to 100% for the three samples with immature granulocytes > or = 3%. Calculation of sensitivity and specificity to varying percentages of bands showed poor flagging performance, with many false-positive and false-negative results at all levels.
Transgenic cyclooxygenase-2 expression and high salt enhanced susceptibility to chemical-induced gastric cancer development in mice (2008)

Cyclooxoygenase (COX)-2 overexpression is involved in gastric carcinogenesis. While high-salt intake is a known risk factor for gastric cancer development, we determined the effects of high salt on gastric chemical carcinogenesis in COX-2 transgenic (TG) mice. COX-2 TG mice were developed in C57/BL6 strain using the full-length human cox-2 complementary DNA construct. Six-week-old COX-2 TG and wild-type (WT) littermates were randomly allocated to receive alternate week of N-methyl-N-nitrosourea (MNU, 240 p.p.m.) in drinking water or control for 10 weeks. Two groups of mice were further treated with 10% NaCl during the initial 10 weeks. All mice were killed at the end of week 50. Both forced COX-2 overexpression and high-salt intake significantly increased the frequency of gastric cancer development in mice as compared with WT littermates treated with MNU alone. However, no additive effect was observed on the combination of high salt and COX-2 expression. We further showed that MNU and high-salt treatment increased chronic inflammatory infiltrates and induced prostaglandin E(2) (PGE(2)) production in the non-cancerous stomach. Whereas high-salt treatment markedly increased the expression of inflammatory cytokines (tumor necrosis factor-alpha, interferon-gamma, interleukin (IL)-1 beta and IL-6) in the gastric mucosa, COX-2 overexpression significantly altered the cell kinetics in the MNU-induced gastric cancer model. In conclusion, both high salt and COX-2 overexpression promote chemical-induced gastric carcinogenesis, possibly related to chronic inflammation, induction of PGE(2), disruption of cell kinetics and induction of inflammatory cytokines.
Tolerance to host minor histocompatibility antigens after allogenic bone marrow transplantation. Specific donor-host unresponsiveness is maintained by peripheral tolerizing cells (1992)

The development of graft-host tolerance after allogeneic bone marrow (BM) transplantation is more demanding than the acquisition of self-tolerance because both donor-derived mature T cells and immature thymocytes encounter host Ag. The mechanism involved in tolerization of mature T cells, contained in unmanipulated BM, remains undefined. In previous experiments, we showed in vivo unresponsiveness to host minor histocompatibility Ag (MiHA) in immunocompetent chimeras obtained after MiHA-incompatible BM transplantation. In this study, we wanted to determine: first, what was the specificity of this graft-host unresponsiveness, and second, whether peripheral cells were involved in tolerization? LP recipients were irradiated (9, 5 Gy), injected with 10(7) undepleted BM cells from B10 donors and studied 100 to 150 days later. (B10-->LP) chimeras were immunized in vivo and restimulated in vitro with cells displaying one or multiple incompatible MiHA. In bulk culture experiments, chimeras demonstrated specific CTL unresponsiveness to host MiHA but responded normally to third party MiHA. In limiting dilution analysis conditions, chimeras showed a profound deficit, but not a complete absence of anti-host CTL precursor. Studies with congenic stimulators/targets showed that graft-host tolerance was induced against both immunodominant (e.g., H-3.2) and nonimmunodominant (e.g., H-8.2) MiHA although at the CTL precursor level, it was more complete against the former. Furthermore, chimera spleen cells inhibited the generation of CTL activity against host- and donor-type MiHA but not against third party Ag. This specific suppressor activity was not T cell dependent, and was mediated by radiosensitive cells that are not found in freshly explanted organs from normal mice. Taken together, our results suggest that peripheral tolerization can be a remarkably efficient process to maintain tolerance to MiHA after BM transplantation. Thus, peripheral tolerizing mechanisms may contribute not only to the induction of tolerance to Mls superantigens or to the product of transgenes (if expressed at high levels) but also to a wide array of MiHA.
On excess current during and after partial discharge activity (2014)

Among the factors influencing partial discharge (PD) activity in insulation systems, deposition of electric charges on dielectrics significantly impact the subsequent behaviour. This work presents a measurement technique that allows studying the charge released during PD events by measuring the resulting excess current. The method, being similar to the dielectric response analysis, measures the current flowing through a test object before, during and after a PD event. By comparing the dielectric (capacitive) and the total currents, the charging process as well as its decay can be explored. The applicability of the method is demonstrated when analysing PD activity in a twistedpair test object exposed to a square voltage waveforms.
Hydrogels: Scalable High‐Throughput Production of Modular Microgels for In Situ Assembly of Microporous Tissue Scaffolds (Adv. Funct. Mater. 25/2019) (2019)

In article number 1900071, Dino Di Carlo and co-workers show that parallel drop generation in a step emulsification device leads to large scale monodisperse microgel formation following a pH transition. These microgel particles are annealed together at points of contact leading to an interconnected microporous scaffold that greatly enhances cell proliferation and growth. The scalable manufacture promises to enable translation of these scaffolds in 3D printing and regenerative medicine applications.
Building Bowls for Miscellaneous Media (2006)

The protective effects of soyasaponins-rich extract (SRE) from soybean against acute alcohol-induced hepatotoxicity were first investigated in the Institute of Cancer Research mice. Administration of SRE prior to alcohol significantly prevented the increases in serum aspartate transaminase, alanine transaminase, alkaline phosphatase, and lactate dehydrogenase caused by alcohol, as well as hepatic triglyceride, total cholesterol, and malondialdehyde levels. Mice treated with SRE showed a better profile of the antioxidant system with normal superoxide dismutase, glutathione S-transferase, and glutathione peroxidase activities, which were associated with the increase of hepatic glutathione levels relative to the acute alcohol-treated group. Supplement of SRE prevented alcohol-induced hepatic steatosis necrosis, inflammation, and swelling, as indicated by liver histopathological studies. All of these findings demonstrate that SRE has protective effects on acute alcohol-induced liver damage.
Calendar-Aware Proactive Email Recommendation (2018)

In this paper, we study how to leverage calendar information to help with email re-finding using a zero-query prototype, Calendar-Aware Proactive Email Recommender System (CAPERS). CAPERS proactively selects and displays potentially useful emails to users based on their upcoming calendar events with a particular focus on meeting preparation. We approach this problem domain through a survey, a task-based experiment, and a field experiment comparing multiple email recommenders in a large technology company. We first show that a large proportion of email access is related to meetings and then study the effects of four email recommenders on user perception and engagement taking into account four categories of factors: the amount of email content, email recency, calendar-email content match, and calendar-email people match. We demonstrate that these factors all positively predict the usefulness of emails to meeting preparation and that calendar-email content match is the most important. We study the effects of different machine learning models for predicting usefulness and find that an online-learned linear model doubles user engagement compared with the baselines, which suggests the benefit of continuous online learning.
Convenient Synthesis of Functionalized Terphenyls. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
The Hemodynamic and Neurohormonal Effects of Low Doses of Tezosentan (An Endothelin A/B Receptor Antagonist) in Patients with Acute Heart Failure (2004)

In patients admitted with AHF, tezosentan doses of 1-25 mg/h are efficacious in improving the hemodynamics and reducing BNP. Tezosentan doses beyond 1 mg/h increased plasma endothelin levels and reduced urine output, probably limiting their clinical efficacy, as compared to tezosentan 1 mg/h.
Recent progress in domain wall motion in artificially engineered racetracks driven by spinorbit torques (2015)

This paper discusses the giant current-induced domain wall velocities in artificially engineering racetracks of magnetic memory devices. It is shown that nano-second long current pulses can move domain walls in synthetic antiferromagnetic racetracks that have nearly no net magnetization and found that the domain walls can be moved even more efficiently and at much higher speeds of up to ~1,000 m/sec compared to similar racetracks in which the sub-layers are coupled ferromagnetically.
Faculty Opinions recommendation of Nitrosative stress drives heart failure with preserved ejection fraction. (2019)

Heart failure with preserved ejection fraction (HFpEF) is a common, morbid, and mortal syndrome for which there are no evidence-based therapies. Here, we report that concomitant metabolic and hypertensive stress in mice elicited by a combination of high fat diet (HFD) and constitutive nitric oxide (NO) synthase inhibition by N [w] -nitro-l-arginine methyl ester (L-NAME) recapitulates the numerous systemic and cardiovascular features of human HFpEF. One of the unfolded protein response (UPR) effectors, the spliced form of X-box binding protein 1 (Xbp1s), was reduced in the myocardium of both experimental and human HFpEF. Mechanistically, the
Supplementary Material from An Expression Signature as an Aid to the Histologic Classification of Non–Small Cell Lung Cancer (2023)

&lt;p&gt;Extended HTG EdgeSeq methodology&lt;/p&gt;
Anonymous On-Demand Position-based Routing in Mobile Ad-hoc Networks (2006)

Due to the infrastructure-less, dynamic, and broadcast nature of radio transmissions, communications in mobile ad-hoc networks, MANETs, are susceptible to malicious traffic analysis. After performing traffic analysis, an attacker conducts an intensive attack (i.e., a target-oriented attack) against a target node specified by the traffic analysis. Because of the degradation of both throughput and security of routing, traffic analysis and its subsequent target-oriented attack are known as serious problems in regards to MANETs. Basically, position information of routing nodes is very sensitive data in MANETs, where even nodes not knowing each other establish a network temporarily. It is desirable that position information is kept secret. All of these problems are especially prominent in position-based routing protocols of MANETs. Therefore a new position-based routing protocol, which keeps routing nodes anonymous, thereby preventing possible traffic analysis, is proposed. The proposed scheme uses a time-variant temporary identifier, Temp ID, which is computed from the time and position of a node and used for keeping the node anonymous. Only the position of a destination node is required for the route discovery, and the Temp ID is used for establishing a route for sending data. A receiver dynamic-handshake scheme is designed for determining the next hop on-demand by using the Temp ID. The level of anonymity and the performance of this scheme were evaluated. The evaluation results show that the proposed scheme ensures the anonymity of both route and nodes and robustness against a target-oriented attack and other attacks. Moreover, this scheme does not depend on node density as long as nodes are connected in the network.
A Method for Rapid RSA Key Generation (1990)

Abstract The RSA public key cryptosystem is one of the cryptosystems which can be applied not only to the security protection but also to the verifications of other users and messages. It is one of the most important techniques in ensuring the security of information. To construct a secure RSA public key cryptosystem, the key must be generated using primes which are robust against a “( p + 1) factorizing attack.” For this purpose, Gordon proposed a method of generating the key by sieving using known primes less than 8 bit and by employing the higher‐order exponential calculation. This paper is an extension of Gordon's approach. The range of known primes is defined optimally through an evaluation for the sieving primes less than 32 bit. The exponential calculation is simplified. The method is implemented on a program. Numerical experiment is made on a 32‐bit workstation, and the practical usefulness of the method is verified.
JEI Letters (2005)

The <i>Journal of Electronic Imaging</i> (JEI), copublished bimonthly with the Society for Imaging Science and Technology, publishes peer-reviewed papers that cover research and applications in all areas of electronic imaging science and technology.
ChemInform Abstract: Cyclopropyl Building Blocks in Organic Synthesis. Part 66. A New and Efficient Access to Thiazoline‐4‐carboxylates and Cysteine Derivatives Incorporating Cyclopropyl Groups. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Immunoregulatory properties of T‐cell lines derived from the systemic and intrathecal compartments: A phenotypic and functional study (1990)

To determine whether immune regulation can differ within the intrathecal and systemic compartments, we compared phenotypic markers and functional properties of in vitro anti-CD3 monoclonal antibody-stimulated, interleukin 2-expanded lymphoid cell lines simultaneously derived from peripheral blood and cerebrospinal fluid of individual donors (n = 9). We found that the proportions of total CD8+ T cells and of the putative CD8+ suppressor effector subset (CD28-) were lower in the cell lines derived from cerebrospinal fluid compared with cultures derived from peripheral blood (p less than 0.025 and p less than 0.005, respectively; paired t test), whereas the total CD4+ T-cell proportion was higher (p less than 0.025). For a donor subgroup with "normal" peripheral blood cell-mediated activated suppressor function (63 +/- 2%), mean suppressor cell function mediated by unfractionated or CD8(+)-enriched cells derived from cerebrospinal fluid was significantly lower (38 +/- 7%; p less than 0.01, paired t test). For a donor subgroup with "low" peripheral blood cell-mediated suppression (-1 +/- 10%), suppression mediated by cerebrospinal fluid cells was also "low" (9 +/- 12%). Our results support the postulate that the immune response may be differentially regulated between the central nervous system and peripheral blood compartments.
Commercial inverted microscope retrofitted for confocal scanning with multi-wavelength detection, spatially resolved spectroscopy, and fluorescence anisotropy (2002)

We have developed a confocal laser scanning retrofit to a commercial inverted microscope capable of multi-wavelength fluorescence detection, spatially resolved spectroscopy, and fluorescence anisotropy imaging. Examples in tumor spheroids, cells, and murine tumors are given.