gebhart/patrepeval huggingface dataset:
The Scaffold Protein CNK1 Interacts with the Tumor Suppressor RASSF1A and Augments RASSF1A-induced Cell Death (2004)

The connector enhancer of KSR (CNK) is a multidomain scaffold protein discovered in Drosophila, where it is necessary for Ras activation of the Raf kinase. Recent studies have shown that CNK1 also interacts with RalA and Rho and participates in some aspects of signaling by these GTPases. Herein we demonstrate a novel aspect of CNK1 function, i.e. reexpression of CNK1 suppresses tumor cell growth and promotes apoptosis. As shown previously for apoptosis induced by Ki-Ras(G12V), CNK1-induced apoptosis is suppressed by a dominant inhibitor of the mammalian sterile 20 kinases 1 and (MST1/MST2). Immunoprecipitates of MST1 endogenous to LoVo colon cancer cells contain endogenous CNK1; however, no association of these two polypeptides can be detected in a yeast two-hybrid assay. CNK1 does, however, bind directly to the RASSF1A and RASSF1C polypeptides, constitutive binding partners of the MST1/2 kinases. Deletion of the MST1 carboxyl-terminal segment that mediates its binding to RASSF1A/C eliminates the association of MST1 with CNK1. Coexpression of CNK1 with the tumor suppressive isoform, RASSF1A, greatly augments CNK1-induced apoptosis, whereas the nonsuppressive RASSF1C isoform is without effect on CNK1-induced apoptosis. Overexpression of CNK1-(1-282), a fragment that binds RASSF1A but is not proapoptotic, blocks the apoptosis induced by CNK1 and by Ki-Ras(G12V). Thus, in addition to its positive role in the proliferative outputs of active Ras, the CNK1 scaffold protein, through its binding of a RASSF1A.MST complex, also participates in the proapoptotic signaling initiated by active Ras.
Remodeling of the Microenvironment by Aggressive Melanoma Tumor Cells (2003)

A necessity for development and tumor progression is a blood supply formed by vasculogenic and/or angiogenic events, involving the cooperative interactions of cells with their microenvironment. Based on the recent characterization of vasculogenic mimicry by aggressive melanoma cells, particularly their ability to express VE (vascular endothelial)-cadherin, TIE-1, and EphA2, current studies have focused on the molecular signals deposited by these cells as they remodel their microenvironment. The experimental approach utilizes unique three-dimensional collagen matrices preconditioned by metastatic melanoma cells, which contain laminin 5 gamma2 chain-enriched tracks with promigratory cleavage fragments produced by cooperative interactions with specific matrix metalloproteinases (MMPs). The results demonstrate that the collagen matrices preconditioned by the metastatic cells induce poorly aggressive melanoma cells to express, for the first time, key angiogenic/vasculogenic/matrix-remodeling genes. Treatment of aggressive melanoma cells with an MMP inhibitor resulted in the inhibition of vasculogenic mimicry-associated genes in these tumor cells and abrogation of the inductive effects of the preconditioned matrix on poorly aggressive melanoma cells. These observations illustrate the remarkable influence of the microenvironment on the phenotype of melanoma cells and may provide new perspectives on tumor cell plasticity and unique treatment strategies.
Solution-processed highly bright and durable cesium lead halide perovskite light-emitting diodes (2016)

Recently, CsPbBr<sub>3</sub> perovskites have been emerging as very promising green emission materials for light-emitting diodes (LEDs) due to their high color purity, low cost and high photoluminescence quantum yield (PLQY). However, the corresponding LED performance is still low and far behind CH<sub>3</sub>NH<sub>3</sub>PbBr<sub>3</sub>; it is due to the lack of proper perovskite film preparation methods and interfacial engineering. Herein, we report highly bright and durable CsPbBr<sub>3</sub>-based LEDs fabricated using a one-step solution method. The precursor solution is prepared by simply dissolving CsPbBr<sub>3</sub> powder and a CsBr additive in dimethyl sulfoxide (DMSO). We find that the CsBr additive not only significantly enhances the PLQY but also induces directional crystal growth into micro-plates, forming a smooth perovskite film for LEDs. LEDs employing such high quality films show a high luminance of 7276 cd m<sup>-2</sup> and high color purity with a full width at half maximum of 18 nm. Furthermore, the as-fabricated LEDs reveal an outstanding ambient stability with a decent luminance output (>100 cd m<sup>-2</sup>, steady increase without any degradation trend) for at least 15 h under a constant driving current density (66.7 mA cm<sup>-2</sup>). And we propose two reasons for this unique luminance increasing behavior: (1) the CsPbBr<sub>3</sub> perovskite is thermally stable and can survive from joule heat; and (2) on the other hand, the joule heating will induce interface or crystalline film annealing, reduce device resistance and then enhance the luminance output.
PYY (3-36) protects against high fat feeding induced changes of pancreatic islet and intestinal hormone content and morphometry (2023)

These observations highlight mechanisms linked to the metabolic and weight reducing benefits of PYY(3-36).
Intelligent system for predicting wireless sensor network performance in on-demand deployments (2012)

The need for advanced tools that provide efficient design and planning of on-demand deployment of wireless sensor networks (WSN) is critical for meeting our nation's demand for increased intelligence, reconnaissance, and surveillance in numerous safety-critical applications. For practical applications, WSN deployments can be time-consuming and error-prone, since they have the utmost challenge of guaranteeing connectivity and proper area coverage upon deployment. This creates an unmet demand for decision-support systems that help manage this complex process. This paper presents research-in-progress to develop an advanced decision-support system for predicting the optimal deployment of wireless sensor nodes within an area of interest. The proposed research will have significant impact on the future application of WSN technology, specifically in the emergency response, environmental quality, national security, and engineering education domains.
ChemInform Abstract: Synthesis and Biological Activity of a Novel Series of Nonsteroidal, Peripherally Selective Androgen Receptor Antagonists Derived from 1,2‐Dihydropyridono[5,6‐g]quinolines. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Necessity Is the Mother of Invention: The Development of Digital Genomics (2016)

Featured Article: Vogelstein B, Kinzler KW. Digital PCR. Proc Nat Acad Sci USA 1999;96:9236–41.3

An oft-cited proverb is that “necessity is the mother of invention,” and that is certainly the case for the development of digital PCR and the advent of digital genomics. In the early 1990s, we were exploring the use of released tumor DNA as a clinical biomarker. Tumor DNA can be readily distinguished from normal DNA by the presence of somatic driver gene mutations. We had already demonstrated that released tumor DNA could be detected in the urine or stool of patients with bladder or colorectal cancers, respectively, and sought to apply this approach to other bodily fluids, particularly plasma. However, the success of this approach was limited by the small amounts of tumor DNA and the large excess of DNA from normal cells in such clinical samples. How could one maximize the analytical specificity and sensitivity for the detection of rare mutant DNA molecules released from tumors? This question prompted the realization that maximum specificity could be achieved by genetically characterizing one molecule at a time. The featured article described the manifestation of this realization, called digital PCR. The increased signal-to-noise ratio obtained by this approach is conceptually identical to the increased signal-to-noise ratio associated with digital as compared to analog technologies in electronics.

Digital PCR introduced the concept of digital genomics. With digital PCR, individual DNA template molecules are separately amplified and genetically characterized. This was achieved by optimizing the amplification of individual DNA templates in confined spaces (initially, in wells of a 384-well plate) in …
Nuclear Factor of Activated T Cells (NFAT1‐C) Represses the Enhancer II and Pregenomic Promoter (EnII/Cp) of Hepatitis B Virus (HBV) Through its Responsive Site GGAGA and Nullifies the HBx‐Driven Transcriptional Activation (2001)

The immunosuppressant cyclosporin A (CsA)-sensitive nuclear factor of activated T cells 1 (NFAT1) has been known to be a transcriptional regulator of cytokine and viral genes during the immune response. By analyses of serial deletion, mutation, and heterologous promoter assay, we report here that the CsA-sensitive NFAT1-C represses the transcriptional activity of enhancer II and pregenomic promoter (EnII/Cp) of HBV through the NFAT1-C responsive site (GGAGA, nt 1603-1618) and nullifies the HBx-driven transcriptional activation of the EnII/Cp of HBV in a dose-dependent manner. These results suggest that a CsA-sensitive NFAT1-C may control the viral activity in HBV-infected cells by inhibiting the EII/Cp and nullifying the HBx-driven transcriptional activation.
Supercapacitors: Asymmetric Carbon Nanohorn Enabled Soft Capacitors with High Power Density and Ultra‐Low Cutoff Frequency (Adv. Mater. Technol. 9/2020) (2020)

In article number 2000372, Bo Hou, Gehan A. J. Amaratunga, and co-workers present asymmetric carbon nanohorns as an active material to fabricate flexible solid-state carbon wire-based electrochemical supercapacitors, which exhibit remarkable specific length capacitance and charge-discharge stability. Furthermore, a high-pass filter for eliminating ultra-low electronic noise is demonstrated, which enables an optical Morse Code communication system to be operated.
Figure S2 from A novel class of Ribosome Modulating Agents (RMAs) exploits cancer ribosome heterogeneity to selectively target the CMS2 subtype of colorectal cancer (2023)

&lt;p&gt;Results for pSILAC Mass Spec study demonstrating ZKN-157 inhibits translation of a subset of proteins&lt;/p&gt;
Bleomycin in older early-stage favorable Hodgkin lymphoma patients: analysis of the German Hodgkin Study Group (GHSG) HD10 and HD13 trials (2016)

Doxorubicin, bleomycin, vinblastine sulfate, and dacarbazine (ABVD) is associated with severe toxicity in older patients, particularly from bleomycin-induced lung toxicity (BLT). Therefore, using bleomycin has been questioned in older Hodgkin lymphoma (HL) patients, especially in early-stage HL. We therefore analyzed feasibility, toxicity, and efficacy of ABVD or AVD in 287 older early-stage favorable HL patients. We included patients ≥60 years of age in the German Hodgkin Study Group HD10 and HD13 trials randomized to either 2 cycles of ABVD (2×ABVD; n = 137) or AVD (2×AVD; n = 82), each followed by involved-field radiotherapy (IF-RT), with patients randomized to 4×ABVD+IF-RT (n = 68). Patients' median age was 65 years (range, 60-75) with comparable patient and disease characteristics. Grade III-IV adverse event rates were similar in patients receiving 2×AVD and 2×ABVD (40% and 39%, respectively), but considerably higher in patients receiving 4×ABVD (65%). Similarly, BLT was rare in patients receiving 2×ABVD/AVD, but occurred in 7/69 (10%) of patients randomized to 4×ABVD, with 3 lethal events. In conclusion, no effects of bleomycin on toxicity rates were detectable in older patients receiving 2 cycles of chemotherapy. However, we found a high risk of severe toxicity of bleomycin in older HL patients receiving more than 2 cycles of ABVD. These trials are registered at www.clinicaltrials.gov and www.isrctn.com as #NCT00265018 (HD10) and #ISRCTN63474366 (HD13).
Impact of filtering on RZ-DPSK reception (2003)

We discuss the influence of optical and electrical filtering on the performance of beat-noise limited balanced and single-ended direct detection of return-to-zero differential phase-shift keying (DPSK). Our simulations, supported by 40-Gb/s measurements, show that balanced DPSK detection outperforms both its single-ended equivalent and ON-OFF keying by /spl sim/2.7 dB, with higher gains at narrower optical filter bandwidths.
BeSbTe stoichiometric engineering dataset (2019)

Dataset for Piccinotti, D., Gholipour, B., Yao, J., MacDonald, K. F., Hayden, B. E., &amp; Zheludev, N. I. (2019). Stoichiometric engineering of chalcogenide semiconductor alloys for nanophotonic applications. Advanced Materials, 31(14), [1807083]. DOI: 10.1002/adma.201807083
Organ-specific transcripts of different size and abundance derive from the same pyruvate, orthophosphate dikinase gene in maize. (1990)

Analyses of genomic DNA and clones indicate that the pyruvate, orthophosphate dikinase (PPDK; ATP: pyruvate, orthophosphate phosphotransferase, EC 2.7.9.1) gene family of maize (Zea mays L. subsp. mays, line B73) contains two members. Restriction site and DNA sequence comparisons between PPDK genomic and leaf cDNA clones have revealed which gene encodes the isozyme involved in C4 photosynthesis. The region flanking the 5' end of this gene contains two 30-base-pair (bp) repetitive elements that may be involved in its light-regulated expression. Sequence analysis of genomic and leaf cDNA clones has also shown that the entire 7.3-kDa PPDK chloroplast transit peptide is encoded in the 436-bp first exon. Northern blot experiments with probes specific for the first exon and the 3' end of the gene showed that the smaller PPDK transcripts in roots and etiolated leaves [3.0 kilobases (kb) vs. the 3.5-kb green leaf transcript] lack the sequence encoding the chloroplast transit peptide. In addition, results from cDNA library screens have confirmed that the root transcript is approximately 50-fold less abundant than the green leaf transcript. Finally, sequence comparisons among cDNA clones from green leaves and roots and genomic clones representing both members of the PPDK gene family demonstrate that the green leaf transcript encoding the C4 isozyme and the root transcript are derived from the same gene.
Polymorphisms in the Human Tropoelastin Gene Modify In Vitro Self-Assembly and Mechanical Properties of Elastin-Like Polypeptides (2012)

Elastin is a major structural component of elastic fibres that provide properties of stretch and recoil to tissues such as arteries, lung and skin. Remarkably, after initial deposition of elastin there is normally no subsequent turnover of this protein over the course of a lifetime. Consequently, elastic fibres must be extremely durable, able to withstand, for example in the human thoracic aorta, billions of cycles of stretch and recoil without mechanical failure. Major defects in the elastin gene (ELN) are associated with a number of disorders including Supravalvular aortic stenosis (SVAS), Williams-Beuren syndrome (WBS) and autosomal dominant cutis laxa (ADCL). Given the low turnover of elastin and the requirement for the long term durability of elastic fibres, we examined the possibility for more subtle polymorphisms in the human elastin gene to impact the assembly and long-term durability of the elastic matrix. Surveys of genetic variation resources identified 118 mutations in human ELN, 17 being non-synonymous. Introduction of two of these variants, G422S and K463R, in elastin-like polypeptides as well as full-length tropoelastin, resulted in changes in both their assembly and mechanical properties. Most notably G422S, which occurs in up to 40% of European populations, was found to enhance some elastomeric properties. These studies reveal that even apparently minor polymorphisms in human ELN can impact the assembly and mechanical properties of the elastic matrix, effects that over the course of a lifetime could result in altered susceptibility to cardiovascular disease.
ChemInform Abstract: Pyrrole[2,3‐d]azepino Compounds as Agonists of the Farnesoid X Receptor (FXR). (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
C1 dictionaries colloquium: Collaborative dictionary making with WeSay (2011)

More and more dictionary projects today have multiple authors. This is especially the case for projects which seek to involve community members in the compilation process. But how can teams collaborate if they don't all live in the same location and they don't all have unlimited access to the Internet? This paper presents a new solution: Chorus developed by the creators of WeSay.
ChemInform Abstract: A Convenient Access to Furo[3,2‐c]pyridin‐6(5H)‐ones by the Reaction of 5‐Iodo‐4‐methoxy‐2‐pyridones with Terminal Alkynes under Microwave‐Enhanced Sonogashira Conditions. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Historia de las deficiencias. Responsible test use . Case studies for assessing human behavior (1996)

La publicacion de un nuevo libro en el campo de las deficiencias siempre es interesante e importante, pero en este caso lo es mucho mas. La relevancia que presenta esta Historia de las deficiencias procede de varios motivos.

En primer lugar, porque viene a llenar un gran vacio existente en el ambito que nos ocupa, presentando la peculiaridad de ser obra pionera en el tratamiento conjunto de todas las deficiencias. En segundo lugar, porque este texto resulta de la conjuncion de la amplia experiencia profesional y academica del autor en el campo de las deficiencias, lo que redunda en una vision mas amplia y comprehensiva del tema. En tercer lugar, porque en este recorrido historico el autor elige como criterio de demarcacion temporal las llamadas tres revoluciones en salud mental. De una lado, con la eleccion de este criterio, el profesor Aguado ha conseguido conectar el campo de las deficiencias con las corrientes dominantes en las ciencias de la salud y superar el aislamiento tradicional (la marginacion, tambien academica) con que han sido abordados sus temas y problematica.
Este libro es el resultado del trabajo realizado por dos comites del Joint Committee on Testing Practices (JCTP): The Test User Qualifications Working Group (TUQWoG) y The Test User Training Work Group (TUTWoG), cuyo objetivo es potenciar el uso adecuado de los tests. La investigacion fue patrocinada por The American Counseling Association, The American Psychological Association, The American Speech-Language-Hearing Association y The National Association of School Psychologists.
Science and mathematics teachers’ core teaching conceptions and their implications for engaging in cross-curricular innovations (1970)

Previous studies have found core teaching conceptions (CTCs) to influence teachers’ actions, i.e. how they engage with new teaching practices (e.g. Lotter, Harwood, &amp; Bonner, 2007). This study explores typical CTCs and their subject specific nature in a sample of teachers from physics, biology, and mathematics in Danish upper secondary school. Teachers’ CTCs were investigated through their essay responses to a set of open core questions, administered through a web-platform. Results demonstrate that teachers’ CTCs come in subject specific flavours, encompassing their purpose for teaching the subject, their conceptions of teaching and learning, and their conceptions of interdisciplinary teaching. It is argued that such differences shape teachers’ engagement with new cross-curricular innovations in the Danish context. Assessing and addressing typical and personal CTCs are found to be crucial to a successful implementation of current reform-initiatives, for teacher training, and for self-regulated professional development among teachers.
Synthesis of an Esterase-Sensitive Cyclic Prodrug of a Model Hexapeptide Having Enhanced Membrane Permeability and Enzymatic Stability Using a 3-(2'-Hydroxy-4',6'-Dimethylphenyl)-3,3-Dimethyl Propionic Acid Promoiety (2003)

One of the major obstacles to the development of biologically active peptides as clinically useful therapeutic agents has been their low permeation through biological barriers (e.g., intestinal mucosa, blood-brain barrier) and their metabolic lability (1,2). Overcoming these problems is a very contemporary issue for the development of peptide pharmaceuticals. In the preceding chapter, we have indicated that masking the C- and N-terminal polar functional groups of a peptide through cyclization with an acyloxyalkoxy linker can greatly enhance the membrane permeation and metabolic stability of the linear peptide (3). In this chapter, we wish to report a method for the preparation of esterase-sensitive cyclic prodrugs of peptides by taking advantage of a unique "trimethyl lock"-facilitated lactonization system (Fig. 1). Substituted phenol propionic acid derivatives such as 2, upon unmasking of the hydroxyl group, undergo a facile spontaneous intramolecular cyclization to release the moieties attached to the carboxyl functional group (Fig. 1) (4-6). The facile cyclization reaction is the result of the "trimethyl lock", which was shown earlier to increase the rate of the cyclization reaction in the order of 10(5-7) (4-7). The result of such facilitation is that compound 2 has a half-life of only approximately 100 s at room temperature in aqueous solution (8,9). Such systems have been used to develop prodrugs of amines and alcohols (8-10) and redox-sensitive protecting groups of amines (11). Fig. 1. The design of an esterase sensitive prodrug system for the cyclic deriva-tization of peptides.
Facile Synthesis of Isotactic Polyacrylonitrile via Template Polymerization in Interlayer Space for Dielectric Energy Storage (2020)

Isotactic polyacrylonitrile (iso-PAN) is synthesized via template polymerization using the two-dimensional layered space of a CoCl2 crystal as a template. Isotacticity of polyacrylonitrile reaches a meso/meso triad = 93% (mm = 0.93), which indicates a superior packing of polymer chains, leading to a high breakdown strength. Tacticity enhancement is correlated with the interatomic (metal–metal) distance of template-layered crystals. Due to a large dipole moment (4.3 D) of nitrile group and a high stereoregularity, iso-PAN demonstrates a high discharge energy density of 6.7 J/cm3 at 660 MV/m, nearly six times that of atactic polyacrylonitrile (ata-PAN) and biaxially oriented polypropylene (BOPP), a commercially available dielectric polymer film. Moreover, it exhibits a charge–discharge efficiency of ca. 90% in a wide applied electric field range, which is higher than the efficiencies of ata-PAN and BOPP. These results suggest that iso-PAN, exhibiting a large dipole moment and high stereoregularity, is a promising candidate for high energy density and low loss capacitor dielectrics.