gebhart/patrepeval huggingface dataset:
Glissement Piloté d'un Système d'Embrayage - Application au Filtrage d'Acyclismes (2009)

National audience
VTMS: a Virtual Terminal Management System for RIG (1979)

Rochester's Intelligent Gateway provides its users with the facilities for communicating simultaneously with a large number of processes spread out among various computer systems. We have adopted the philosophy that the user should be able to manage any number of concurrent tasks or jobs, viewing their output on his display device as he desires. To achieve this goal a single physical terminal is converted in multiple virtual terminals, each of which may be written into or queried for user input. Virtual terminals are device-independent and provide extensive editing facilities and the capacity to maintain all output on disk. (Author)
Discovery of Potent and Selective PI3Kγ Inhibitors (2020)

The selective inhibition of the lipid signaling enzyme PI3Kγ constitutes an opportunity to mediate immunosuppression and inflammation within the tumor microenvironment but is difficult to achieve due to the high sequence homology across the class I PI3K isoforms. Here, we describe the design of a novel series of potent PI3Kγ inhibitors that attain high isoform selectivity through the divergent projection of substituents into both the "selectivity" and "alkyl-induced" pockets within the adenosine triphosphate (ATP) binding site of PI3Kγ. These efforts have culminated in the discovery of 5-[2-amino-3-(1-methyl-1<i>H</i>-pyrazol-4-yl)pyrazolo[1,5-<i>a</i>]pyrimidin-5-yl]-2-[(1<i>S</i>)-1-cyclopropylethyl]-7-(trifluoromethyl)-2,3-dihydro-1<i>H</i>-isoindol-1-one (<b>4</b>, IC<sub>50</sub> = 0.064 μM, THP-1 cells), which displays >600-fold selectivity for PI3Kγ over the other class I isoforms and is a promising step toward the identification of a clinical development candidate. The structure-activity relationships identified throughout this campaign demonstrate that greater γ-selectivity can be achieved by inhibitors that occupy an "alkyl-induced" pocket and possess bicyclic hinge-binding motifs capable of forming more than one hydrogen bond to the hinge region of PI3Kγ.
Ultra-sensitive and selective Hg2+ chemosensors derived from substituted 8-hydroxyquinoline analogues (2013)

A mercury concentration of 15 ppt can be selectively detected, in aqueous medium, thanks to a thiophosphinatylated 8-hydroxyquinoline sensor.
Response of Steroid-Refractory Acute GVHD to α1-Antitrypsin (2016)

α1-Antitrypsin (AAT) is a serine protease inhibitor with anti-inflammatory, antiapoptotic, and immunomodulatory properties. It has therapeutic efficacy in animal models of autoimmune diseases, inflammatory disorders, and transplantation. In a phase I/II open-label single-center study, we administered AAT (Glassia; Baxalta/Kamada, New Ziona, Israel) as salvage therapy to 12 patients with steroid-refractory acute graft-versus-host disease (GVHD). AAT was given i.v. at 2 dose levels over a 15-day course. All patients had grades III or IV GVHD with stage 4 gut involvement. After treatment, plasma AAT levels increased in both cohorts and remained within 2 to 4 mg/mL for the duration of treatment. No clinically relevant toxicities attributable to AAT were observed. GVHD manifestations improved in 8 of 12 patients, and 4 responses were complete. Six patients (50%) were alive at last follow-up (>104 to >820 days). These findings show that AAT is well tolerated and has efficacy in the treatment of steroid-refractory severe acute GVHD. Further studies are warranted.
Supplementary Figure 1 from Reducing TNF Receptor 2<sup>+</sup> Regulatory T Cells via the Combined Action of Azacitidine and the HDAC Inhibitor, Panobinostat for Clinical Benefit in Acute Myeloid Leukemia Patients (2023)

&lt;p&gt;PDF file - 1479K, Comparison of the absolute cell counts of T cells and Tregs.&lt;/p&gt;
Iterative Refinement of the Approximate Posterior for Directed Belief Networks (2016)

Variational methods that rely on a recognition network to approximate the posterior of directed graphical models offer better inference and learning than previous methods. Recent advances that exploit the capacity and flexibility in this approach have expanded what kinds of models can be trained. However, as a proposal for the posterior, the capacity of the recognition network is limited, which can constrain the representational power of the generative model and increase the variance of Monte Carlo estimates. To address these issues, we introduce an iterative refinement procedure for improving the approximate posterior of the recognition network and show that training with the refined posterior is competitive with state-of-the-art methods. The advantages of refinement are further evident in an increased effective sample size, which implies a lower variance of gradient estimates.
A Design of Optical Isolator Utilizing Surface Plasmons in Co / Al<sub>2</sub>O<sub>3</sub> / AlGaAs Waveguides for Integration into Photonic Integrated Circuits (2013)

2013 International Conference on Solid State Devices and Materials,A Design of Optical Isolator Utilizing Surface Plasmons in Co / Al<sub>2</sub>O<sub>3</sub> / AlGaAs Waveguides for Integration into Photonic Integrated Circuits
The rearranged L-myc fusion gene (RLF) encodes a Zn-15 related zinc finger protein. (1995)

We have previously characterized intrachromosomal rearrangements at 1p32 fusing the first exon of the RLF gene with L-myc. Here we present the full-length cDNA sequence of the 6251 bp RLF mRNA. The predicted 1914 amino acid Rlf protein contains sixteen widely spaced zinc finger motifs, and is related to the Zn-15 transcription factor. RLF is widely expressed in fetal and adult tissues, suggesting that it has a general role in transcriptional regulation. The zinc fingers are not contained in the 79 amino acid N-terminal region of RLF involved in the RLF-L-myc fusions, and the transforming ability of the RLF-L-myc and the normal L-myc proteins is indistinguishable. These findings suggest that the role of the rearrangements fusing RLF and L-myc is to deregulate the tightly controlled expression of the L-myc gene.
Development of the Low-Emission GE-7FDL High-Power Medium-Speed Locomotive Diesel Engine (2003)

This paper summarizes the technical development of the low-emission GE-7FDL series locomotive diesel engine. The development focused on reducing the engine exhaust NOx emission significantly while reducing and curbing other visible and nonvisible emissions with minimal adverse impact on the engine fuel efficiency and minimal changes to the engine system and components. Concepts were analyzed, and were investigated using a single-cylinder 7FDL research engine. A low-emission 16-cylinder 7FDL engine and a GE locomotive prototype were built and tested for performance demonstration, function evaluation, and design optimization. The GE low-emission 7FDL engines and locomotives have been in production. The newly developed low-emission locomotive engine meets the EPA Tier-0 levels without fuel efficiency penalty. This was accomplished with minimal changes to the engine system and components. The desired engine reliability performance is retained. The engines are interchangeable with the preceding 7FDL baseline models, and the upgrade of the existing baseline engines to the low-emission version is facilitated.
Robust control of DC-DC converter by high-order approximate 2-degree-of-freedom digital controller (2005)

In many applications of DC-DC converters, loads cannot be specified in advance, i.e., their amplitudes are suddenly changed from the zero to the maximum rating. Generally, design conditions are changed for each load and then each controller is re-designed. Then, a so-called robust DC-DC converter which can cover such extensive load changes and also input voltage changes with one controller is needed. Analog control IC is used usually for the controller of DC-DC converter. Simple integral control etc. is performed with the analog control IC. However it is difficult to retain sufficient robustness of DC-DC converter by these techniques. The authors proposed the method of designing an approximate 2-degree-of-freedom (2DOF) controller of DC-AC converter. This controller has an ability to attain sufficient robustness against extensive load and DC power supply changes. For applying this approximate 2DOF controller to DC-DC converter, it is necessary to improve the degree of approximation for better robustness. In this paper, we propose a method of designing high-order approximate 2DOF digital controller which makes the control bandwidth wider, and at the same time makes a variation of the output voltage very small at a sudden change of resistive load. The proposed high-order approximate 2DOF digital controller is actually implemented on a DSP and is connected to a DC-DC converter. Experimental studies demonstrate that this type digital controller can satisfy given specifications.
Simulated measurements of optical tissue properties from Breast Tomosynthesis guided Diffuse Spectroscopy (2010)

This work studies an approach to combine tomosynthesis breast imaging with near infrared spectroscopy to determine tissue chromphore concentrations using spatial prior tomosythesis data and correlated scatter information.
Next-Generation Single-Use Ureteroscopes: An In Vitro Comparison (2017)

The YouCare single-use fiberoptic flexible ureteroscope and NeoFlex single-use digital flexible ureteroscope perform comparably to current reusable ureteroscopes, possibly making each a viable alternative in the future. Newer YouCare single-use flexible ureteroscopes with a digital platform and two-way deflection may be more competitive, while the NeoFlex devices are undergoing rapid improvement as well. Further testing is necessary to validate the clinical performance and utility of these ureteroscopes, given the wide variety of single-use devices under development.
Minuet: rethinking concurrency control in storage area networks (2009)

Clustered applications in storage area networks (SANs), widely adopted in enterprise datacenters, have traditionally relied on distributed locking protocols to coordinate concurrent access to shared storage devices. We examine the semantics of traditional lock services for SAN environments and ask whether they are sufficient to guarantee data safety at the application level. We argue that a traditional lock service design that enforces strict mutual exclusion via a globally-consistent view of locking state is neither sufficient nor strictly necessary to ensure application-level correctness in the presence of asynchrony and failures. We also argue that in many cases, strongly-consistent locking imposes an additional and unnecessary constraint on application availability. Armed with these observations, we develop a set of novel concurrency control and recovery protocols for clustered SAN applications that achieve safety and liveness in the face of arbitrary asynchrony, crash failures, and network partitions. Finally, we present and evaluate Minuet- a new synchronization primitive based on these protocols that can serve as a foundational building block for safe and highly-available SAN applications. 1
An importance-driven radiosity algorithm (1992)

We present a new radiosi[y algorithm for efficiently computing global solutions with respect to a constrained set of views. Radiosities of directly visible surfaces are computed to high accuracy, while those ot' surfaces having only an indirect effect are computed to an accuracy commensurate with their contribution. The algorithm uses an adaptive subdivision scheme that is guided by the interplay between two closely related transport processes: one propagating power from the light sources, and the other propagating imporrarwc from the visible surfaces. By simultaneously refining approximate solutions to the dud transport equations, computation is significantly reduced in areas that contribute little to the region of interest. This approach is very effective for complex environments in which only a small fraction is visible at any time. Our statistics show dramatic speedups over the fastest previous radiosity algorithms for diffuse environments with details at a wide range of scales.
In Vivo Expansion of NK Cells Stimulated with PM21 Particles Under Ultralow IL-2 (2015)

Cancer immunotherapy with NK cells is promising, but a key challenge is the development of a method that can consistently expand NK cells from a small fraction (∼5%) of unselected PBMCs to a therapeutically effective dose while using "off the shelf" reagents, not requiring long-term complex co-cultures, and with low doses of IL-2. Methods that use feeder cells do expand NK cells, but require complex procedures with prolonged ex vivo co-culture with the feeder cells, are costly, are logistically difficult, and require subsequent administration of high dose IL-2 for persistence after injection. We developed a particle-based method to specifically expand cytotoxic NK cells from unselected PBMCs. These particles, prepared from plasma membrane (PM) of engineered K562 cells that express cytokines such as IL-21 or IL-15 and 41BBL, stimulate in vitro and in vivo expansion of NK cells. In vitro, these PM-particles containing membrane bound IL-21 (PM21-particles) cause highly specific expansion of cytotoxic NK cells from unselected PBMCs by achieving >90% NK cells in 14 days and 104 fold expansion of NK in 21 days. NK cell expansion is consistent with different preparations of PM-particles or leukocyte sources, and the PM-particles retain expansion efficacy with -80°C storage. The PM21-particles also stimulate in vivo NK cell expansion in NSG mice under ultralow IL-2 (1,000 U per injection, 3 x weekly). The efficacy of ex vivo pre-activation with PM21, prior to injection, was tested by injecting PBMCs (2 x 106 PBMCs per mice, i.p., 6 mice per group), which were either activated in culture for two days with 200 μg/mL PM21 (PM21-PBMCs) or not pre-activated (PBMCs), and then the abundance of hCD56+CD3- NK cells and other hCD45+ lymphocytes were monitored in peripheral blood of mice. Clear efficacy for pre-activation was observed where the mice in the group given PM21-PBMCs had 66 fold higher human NK (hNK) cells as compared to the group injected with PBMCs. The efficacy of administering PM21-particles in vivo was examined also where 2 x 106 PM21-PBMCs, were injected i.p. into mice (4 mice per group) that then received 0, 400, 800 or 1600 μg of PM21 (i.p., 2 x weekly). The mice injected with 800 μg of PM21 had the highest amount of hNK cells averaging 890,000 hNK/mL of mouse blood on day 16 and reaching 95 ± 2% of total hCD45+ cells by day 12. By comparing the averages between day 5 and 16 in this experimental group, hNK cell increased a minimum of 390 fold in the mouse blood. Furthermore, examination of organs from mice sacrificed on day 16 after PM21-PBMC injection shows significant numbers of hNK cells in bone marrow, spleen, lung, liver and brain. The extent of NK cells observed in the peripheral blood (>50,000 NK cells/mL blood, 14 days post injection) and biodistribution to sites of disease would be relevant for clinical cancer treatment, and thus shows that PM-particle technology could be suitable for NK cell immunotherapy.
Constant Activation of the RAF-MEK-ERK Pathway As a Diagnostic and Therapeutic Target in Hairy Cell Leukemia. (2012)

Abstract Abstract 2657 The BRAF-V600E mutation defines genetically hairy cell leukemia (HCL) among B-cell leukemias and lymhphomas. In solid tumors, BRAF-V600E is known to aberrantly activate the oncogenic MEK-ERK pathway, and targeted BRAF and/or MEK inhibitors have shown remarkable efficacy in clinical trials of melanoma patients. However, the MEK-ERK pathway status in HCL has not been thoroughly investigated so far. Therefore, as a read-out of MEK-ERK pathway activation, we assessed phospho-ERK expression in 37 HCL patients using immunohistochemistry on routine biopsies and/or Western blotting on purified leukemic cells. Beside confirming the constant presence of BRAF-V600E in all patients, we documented ubiquitous phospho-ERK expression in HCL. Conversely, all 44 HCL-like cases in parallel studied (40 splenic marginal zone lymphoma, 2 HCL-variant and 2 splenic lymphoma/leukemia unclassifiable) were devoid of BRAF-V600E and none expressed phospho-ERK. Lack of phospho-ERK expression was also documented in two exceptionally rare cases of non-HCL CD5-negative B-cell lymphoproliferative disorders not otherwise specifiable that were previously described to harbour the BRAF-V600E mutation on allele-specific PCR (Arcaini et al, Blood 2012;119:188–191), pointing to the presence of this mutation in only a small part of the leukemic clone in these cases. Our findings support the use of phospho-ERK immunohistochemistry in the differential diagnosis between HCL and HCL-like neoplasms and establish the MEK-ERK pathway as a rational therapeutic target in HCL. Disclosures: Tiacci: Not applicable: Dr. Tiacci filed a patent for the clinical use of BRAF mutations as biomarkers of HCL. Other. Inghirami:OncoEthix SA: Research Funding. Falini:Not applicable: Dr. Falini filed a patent for the clinical use of BRAF mutations as biomarkers of HCL. Other.
High-Throughput Production of Single-Cell Microparticles Using an Inkjet Printing Technology (2008)

In this study, a novel biocompatible and inexpensive method for the rapid production of single-cell based microparticles is described. Using an HP DeskJet 550C printer, alginate microparticles containing one to several insulin-producing cells (beta-TC6) were fabricated by coprinting the cells and sodium alginate suspension into a CaCl2 solution. This method is able to generate microparticles of 30–60μm in diameter at a rate as high as 55,000particles∕s. Cell survival assays showed that more than 89% of printed cells survived the fabrication process. The printed beta-TC6 cells demonstrated continuous insulin secretion over a 6day period, which suggests that the printed cells are able to maintain normal cellular function within the microparticles. We show that the printing conditions, such as cell number, alginate concentration, and ionic strengths of CaCl2, influence cellular distribution and geometry of the printed particles. This study presents a simple and high-throughput method to encapsulate single cells, and this technique may be applied in various research investigations, including single-cell analysis, high-throughput drug screening, and stem cell differentiation at the single-cell level.
Reaction between carbon monoxide and a Ti‐polyethylene bond with a MgCl2‐supported TiCl4 catalyst system (1993)

Abstract The reaction between carbon monoxide and the Ti‐polyethylene bond was investigated by using a stopped‐flow polymerization method which can provide quasi‐living polymers with very low molecular weights. Ethylene polymerization was conducted with a typical MgCl 2 ‐supported TiCl 4 catalyst combined with triisobutylaluminium (Al(i‐C 4 H 9 ) 3 ) or Al(CH 3 ) 3 . The quasi‐living polymers were introduced into either the heptane solution saturated with carbon monoxide or the heptane solution containing 13 C‐enriched carbon monoxide at −78°C. The mixture was gradually heated up to room temperature. During this procedure, a small portion of the reaction mixture was taken out at −78°C, 0°C and at room temperature. The polymers produced were analyzed by means of Fourier‐transform infrared spectroscopy, gel‐permeation chromatography, proton nuclear magnetic resonance ( 1 H NMR) and 13 C NMR spectroscopy. The analytical data show that carbon monoxide is predominantly incorporated into the polymers as a ketonic carbonyl.
Abstract 585: A Novel LXR Ligand Reduces LDL Cholesterol in Monkey (2007)

LXRs act as a transcriptional master switch for coordinate regulation of gene expression involved in cellular cholesterol homeostasis encompassing cholesterol transport, catabolism and absorption. ...
Experimental demonstration of reconfigurable and simultaneous wavelength-division-multiplexed multiple-plane optical interconnections (1996)

We report the first experimental demonstration of using wavelength-division-multiplexing and wavelength-selective-detection to facilitate either reconfigurable or simultaneous optical interconnections between one source plane and many detector planes. We show the 10/sup -9/ BER, 155 Mb/s transmission and detection of three different wavelength-multiplexed signals at three detector planes. The reconfigurable interconnection is established with a wavelength separation of 10 nm, and the simultaneous interconnection is established with a wavelength separation of 43 nm.
Treatment of Auricular Hematomas by OK-432: How and Why It Works (2019)

OK-432 therapy is simple, easy, safe, effective, and can be used as a substitute for surgery in the treatment of auricular hematoma.
Non-uniform platinum profiles in diodes: experimental extraction and influence on the switching behaviour (2008)

The charge-carrier lifetime distribution in platinum-diffused power diodes is extracted by means of two complementary spatially-resolved measurement techniques: free-carrier absorption measurements, and deep level transient spectroscopy measurements. Details of the extracted charge-carrier lifetime profiles are discussed in terms of the applied technology process. Finally, it is shown that both the static as well as the dynamic characteristics of the power diodes are in good agreement with numerical device simulations if the platinum profile is accounted for properly.
Glucocorticoids promote the proliferation and antagonize the retinoic acid–mediated growth suppression of Epstein-Barr virus–immortalized B lymphocytes (2000)

Glucocorticoids are able to release Epstein-Barr virus–immortalized (EBV-immortalized) lymphoblastoid B cell lines (LCLs) from the persistent growth arrest induced in these cells by retinoic acid (RA). Moreover, physiologic concentrations of glucocorticoids efficiently antagonized LCL growth inhibition induced by 13-cis-RA; 9-cis-RA; all-trans-RA; and Ro 40-6055, an RA  receptor (RAR) selective agonist. RAR expression levels, however, were not affected by glucocorticoids. Glucocorticoids, but not other steroid hormones, directly promote LCL proliferation, a phenomenon that was mainly mediated by down-regulation of the cyclin-dependent kinase (CDK) inhibitor p27Kip-1. Moreover, glucocorticoids contrasted the up-regulation of p27Kip-1, which was underlying the RA-induced LCL growth arrest, thereby indicating that glucocorticoids and RA signalings probably converge on p27Kip-1. Both antagonism of RA-mediated growth inhibition and promotion of LCL proliferation were efficiently reversed by the glucocorticoid receptor (GR) antagonist RU486, indicating that all of these effects were mediated by GR. Of note, RU486 also proved to be effective in vivo and, in mice, was able to significantly inhibit the growth of untreated LCLs as well as LCLs growth-arrested by RA in vitro. These findings provide a rational background to further evaluate the possible role of glucocorticoids in the pathogenesis of EBV-related lymphoproliferations of immunosuppressed patients. Moreover, GR antagonists deserve further consideration for their possible efficacy in the management of these disorders, and the use of schedules, including both RA and a GR antagonist, may allow a more thorough evaluation of the therapeutic potential of RA in this setting.