gebhart/patrepeval huggingface dataset:
Rationale for the clinical application of flow cytometry in patients with myelodysplastic syndromes: position paper of an International Consortium and the European LeukemiaNet Working Group (2012)

An international working group within the European LeukemiaNet gathered, aiming to determine the role of flow cytometry (FC) in myelodysplastic syndromes (MDS). It was agreed that FC has a substantial application in disease characterization, diagnosis and prognosis. FC may also be useful in predicting treatment responses and monitoring novel and standard therapeutic regimens. In this article the rationale is discussed that flow cytometry should be integrated as a part of diagnostic and prognostic scoring systems in MDS.
Positron annihilation and conductivity measurements on poly(pyrrole tosylate) and poly(pyrrole fluoride) (1990)

Positron lifetimes, Doppler broadening of the annihilation \ensuremath{\gamma} energy, and electrical conductivities have been measured for two conducting polymers, poly(pyrrole tosylate) and poly(pyrrole fluoride), as functions of temperature in the range 10--295 K. The positron-lifetime spectra have been resolved into two exponentials. Positrons are localized in shallow traps, and the lifetime data suggest thermally induced detrapping of positrons at low temperatures. The temperature dependence of the conductivity has been analyzed following the variable-range-hopping model which provides results for the density of states at the Fermi energy [N(${\mathit{E}}_{\mathit{F}}$)] and bipolaron localization length ${\mathrm{\ensuremath{\alpha}}}^{\mathrm{\ensuremath{-}}1}$. Whereas the temperature dependence of the conductivity qualitatively follows this model, it provides incorrect results for N(${\mathit{E}}_{\mathit{F}}$) and ${\mathrm{\ensuremath{\alpha}}}^{\mathrm{\ensuremath{-}}1}$. .AE
Novel Aspects of Tomato Root Colonization and Infection by Fusarium oxysporum f. sp. radicis-lycopersici Revealed by Confocal Laser Scanning Microscopic Analysis Using the Green Fluorescent Protein as a Marker (2002)

The fungus Fusarium oxysporum f. sp. radicis-lycopersici is the causal agent of tomato foot and root rot disease. The green fluorescent protein (GFP) was used to mark this fungus in order to visualize and analyze the colonization and infection processes in vivo. Transformation of F oxysporum f. sp. radicis-lycopersici was very efficient and gfp expression was stable for at least nine subcultures. Microscopic analysis of the transformants revealed homogeneity of the fluorescent signal, which was clearly visible in the hyphae as well as in the chlamydospores and conidia. To our knowledge, this is the first report in which this is shown. The transformation did not affect the pathogenicity. Using confocal laser scanning microscopy, colonization, infection, and disease development on tomato roots were visualized in detail and several new aspects of these processes were observed, such as (i) the complete colonization pattern of the tomato root system; (ii) the very first steps of contact between the fungus and the host, which takes place at the root hair zone by mingling and by the attachment of hyphae to the root hairs; (iii) the preferential colonization sites on the root surface, which are the grooves along the junctions of the epidermal cells; and (iv) the absence of specific infection sites, such as sites of emergence of secondary roots, root tips, or wounded tissue, and the absence of specific infection structures, such as appressoria. The results of this work prove that the use of GFP as a marker for F. oxysporum f. sp. radicis-lycopersici is a convenient, fast, and effective approach for studying plant-fungus interactions.
Influence of backscattered electrons on x-ray tube output (2000)

When energetic are incident on medium-to-high Atomic Number absorbers a substantial fraction are backscattered. This phenomenon is responsible for several undesirable effects in x-ray-tubes, in particular for a reduction in the x-ray output. The extend of this shortfall has been estimated by using Monte Carlo simulation by starting electrons at increasing depth inside the anode. The results indicate that output enhancements of nearly 50 percent could be achieved in principle if the electrons wasted in backscatter events could be trapped inside the anode. To test out this idea a further set of simulations were done by considering a novel anode geometry. Results showed that x-ray tube efficiencies might be substantially enhanced by this approach.
Development of ZrSiO attenuated phase-shift mask for ArF excimer laser lithography (1999)

We have reported that Zirconium Silicon Oxide (ZrSiO) film is one of the most promising materials for attenuated phase shift mask (att. PSM) for ArF excimer laser lithography. In this paper, we report on practical mask characteristics of ZrSiO att.PSM through its fabrication process. Optical constants (refractive index n/extinction coefficient k) of ZrSiO sputtered films vary continuously according to Ar/O<SUB>2</SUB> flow ratios. A reasonable solution to improve spectroscopic property including transmittance at inspection wavelength can be obtained by a bi-layer structure, consisting of two films having different optical constants, that is absorptive film (AF) and transmissive film (TF). By selecting a pair of appropriate optical constants and adjusting thickness of each layer, we developed the bi-layer structure suitable for optical and other required properties. ZrSiO films are etched by chlorine-based gases, especially AF (bottom layer) dry etching using BCl<SUB>3</SUB> gas has high selectivity to quartz substrate. By optimizing dry etching conditions, cross sectional profile has been attained to over 80 deg, moreover no remarkable residues and edge roughness can be seen. These masks are confirmed to have sufficient tolerance to conventional cleaning process by monitoring the change of transmittance or reflectance curve. Consequently, both transmittance and phase shift through fabrication process approached the required specification, plus or minus 0.3% and plus or minus 2 deg, respectively. Inspection or measurement tools for conventional masks are also applicable. In addition, ZrSiO att.PSM is proved to have sufficient durability for ArF excimer laser irradiation.
Development of PGM-free Catalysts for Hydrogen Oxidation Reaction in Alkaline Media (2018)

The goal of this project is to integrate PGM-free anodic electrocatalysts with a novel anion exchange ionomer in a highly performing MEA. The project is in an earlier stage in comparison with well-established PEMFC technology; however, achieving the goals of this project will allow the following Cost: $14/kWh net Start-up/shutdown durability: >5000 cycles Performance @ 0.8 V: 300 mA/cm2
Improved isolation of extracellular vesicles by removal of both free proteins and lipoproteins (2023)

Extracellular vesicles (EVs) are released by all cells into biofluids such as plasma. The separation of EVs from highly abundant free proteins and similarly sized lipoproteins remains technically challenging. We developed a digital ELISA assay based on Single Molecule Array (Simoa) technology for ApoB-100, the protein component of several lipoproteins. Combining this ApoB-100 assay with previously developed Simoa assays for albumin and three tetraspanin proteins found on EVs (Ter-Ovanesyan, Norman et al., 2021), we were able to measure the separation of EVs from both lipoproteins and free proteins. We used these five assays to compare EV separation from lipoproteins using size exclusion chromatography with resins containing different pore sizes. We also developed improved methods for EV isolation based on combining several types of chromatography resins in the same column. We present a simple approach to quantitatively measure the main impurities of EV isolation in plasma and apply this approach to develop novel methods for enriching EVs from human plasma. These methods will enable applications where high-purity EVs are required to both understand EV biology and profile EVs for biomarker discovery.
Evaluated Kinetic and Photochemical Data for Atmospheric Chemistry: Supplement VI. IUPAC Subcommittee on Gas Kinetic Data Evaluation for Atmospheric Chemistry (1997)

This paper updates and extends part of the previous data base of critical evaluations of the kinetics and photochemistry of gas-phase chemical reactions of neutral species involved in atmospheric chemistry [J. Phys. Chem. Ref. Data 9, 295 (1980); 11, 327 (1982); 13, 1259 (1984); 18, 881 (1989); 21, 1125 (1992); 26, 521 (1997)]. The present evaluation is limited to the following families of atmospherically important reactions: Ox, HOx, NOx, and SOx. The work has been carried out by the authors under the auspices of the IUPAC Subcommittee on Gas Phase Kinetic Data Evaluation for Atmospheric Chemistry. Data sheets have been prepared for 151 thermal and photochemical reactions, containing summaries of the available experimental data with notes giving details of the experimental procedures. For each thermal reaction, a preferred value of the rate coefficient at 298 K is given together with a temperature dependence where possible. The selection of the preferred value is discussed and estimates of the accuracies of the rate coefficients and temperature coefficients have been made for each reaction. For each photochemical reaction the data sheets list the preferred values of the photoabsorption cross-sections and the quantum yields of the photochemical reactions together with comments on how they were selected. The data sheets are intended to provide the basic physical chemical data needed as input for calculations which model atmospheric chemistry. A table summarizing the preferred rate data is provided, together with an appendix listing the available data on enthalpies of formation of the reactant and product species.
Ultrasonic Linear Motor Using Multilayer Piezoelectric Actuators (1995)

In order to lower operating voltage and improve the lifetime of an ultrasonic linear motor, we have developed an ultrasonic oscillator with multilayer piezoelectric actuators. Multilayer piezoelectric actuators are operable at low voltage. However, the tensile strength of the multilayer piezoelectric actuator is small. Therefore, the multilayer piezoelectric actuators are build within an elastic body to lower the tensile stress with a compressive preload. Elliptical oscillations are generated by synthesizing two degenerated modes, a first longitudinal mode and a second flexural mode, with π/2 phase difference. As a result of estimating the characteristics of the ultrasonic linear motor with the ultrasonic oscillator, the operating voltage of 10 V p - p , maximum thrust force of 8 N and lifetime of over 5000 hours have been obtained.
Observation of the associated production of a top quark and a Z boson in pp collisions at $$ \sqrt{s} $$= 13 TeV with the ATLAS detector (2020)

A bstract Single top-quark production in association with a Z boson, where the Z boson decays to a pair of charged leptons, is measured in the trilepton channel. The proton-proton collision data collected by the ATLAS experiment from 2015 to 2018 at a centre-of-mass energy of 13 TeV are used, corresponding to an integrated luminosity of 139 fb − 1 . Events containing three isolated charged leptons (electrons or muons) and two or three jets, one of which is identified as containing a b -hadron, are selected. The main backgrounds are from $$ t\overline{t}Z $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>t</mml:mi> <mml:mover> <mml:mi>t</mml:mi> <mml:mo>¯</mml:mo> </mml:mover> <mml:mi>Z</mml:mi> </mml:math> and diboson production. Neural networks are used to improve the background rejection and extract the signal. The measured cross-section for t ℓ + ℓ − q production, including non-resonant dilepton pairs with $$ {m}_{{\mathrm{\ell}}^{+}{\mathrm{\ell}}^{-}} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msub> <mml:mi>m</mml:mi> <mml:mrow> <mml:msup> <mml:mi>ℓ</mml:mi> <mml:mo>+</mml:mo> </mml:msup> <mml:msup> <mml:mi>ℓ</mml:mi> <mml:mo>−</mml:mo> </mml:msup> </mml:mrow> </mml:msub> </mml:math> &gt; 30 GeV, is 97 ± 13 (stat.) ± 7 (syst.) fb, consistent with the Standard Model prediction.
Phytochemical Profile and Biological Activity of Endemic Sideritis sipylea Boiss. in North Aegean Greek Islands (2020)

<i>Sideritis sipylea</i> Boiss. is an endemic plant of the Mediterranean basin that is distributed in the Greek islands of the North Aegean Sea, i.e., Lesvos, Chios, Samos, and Ikaria, and in the West and Middle peninsula of Turkey. It is considered an endangered species because of its uncontrolled collection from its original habitat. Although the antioxidant, anti-inflammatory and antimicrobial properties have been previously reported, the total chemical profile has not yet been explored. In this context, the chemical profiles of the water/methanol (HA), methanol (ME), and ethyl acetate (EtOAc) extracts were analyzed using ultra-performance liquid chromatography coupled with high-resolution mass spectrometry (UPLC-HRMS). In parallel, analysis by gas chromatography-mass spectrometry (GC-MS) was employed for the dichloromethane extract (DCM) as well as for the essential oil (EO) and the extract obtained by supercritical fluid extraction (SFE). Furthermore, the total phenolic content (TPC) along with the in vitro tyrosinase and elastase enzyme inhibitory activity of different extracts was evaluated, towards the discovery of new active agents for cosmetic formulations. These activities are in accordance with its well-known antioxidant and anti-inflammatory properties, confirming the importance of ethnopharmacological references for <i>S. sipylea</i> in Greece and Turkey.
Applied bias slewing in transient Wigner function simulation of resonant tunneling diodes (1997)

The Wigner function formulation of quantum mechanics has shown much promise as a basis for accurately modeling quantum electronic devices, especially under transient conditions. In this work, we demonstrate the importance of using a finite applied bias slew rate (as opposed to instantaneous switching) to better approximate experimental device conditions, and thus to produce more accurate transient Wigner function simulation results. We show that the use of instantaneous (and thus unphysical) switching can significantly impact simulation results and lead to incorrect conclusions about device operation. We also find that slewed switching can reduce the high computational demands of transient simulations. The resonant tunneling diode (RTD) is used as a test device, and simulation results are produced with SQUADS (Stanford QUAntum Device Simulator).
A Preparation-Free X-ray Imaging Capsule for Colon Cancer Screening (2016)

FigureIntroduction: Patients are often reluctant to undergo optical colonoscopy for colorectal cancer screening due to fear of discomfort and inconvenience related to the cathartic preparation, as well as the anticipated pain, discomfort, inconvenience, and potential complications related to the procedure. A novel x-ray imaging capsule that does not require bowel preparation may increase adherence to CRC screening. Methods: X-Ray based imaging capsules similar in dimensions to other approved capsules were swallowed by 54 volunteers aged 41-70 and tracked during the entire passage of the capsule through the alimentary tract using radio frequency telemetry and a capsule localization system (CPS). The system performed scans upon detecting effective capsule motion in the colon and transmitted imaging data to an external recorder unit attached to patients' lower back. Combined data from colon scans and the CPS system were used to reconstruct 3D colon segments in non-prepped colons. The video will highlight 3 cases of polyps found on both colonosocpy and x-ray imaging capsule. Results: The volunteers were exposed to an ultra-low total radiation dose 0.03 ± 0.0007 mSv (equivalent to 1 chest x-ray) for the entire procedure. The capsule detected polyps of different size, shape and location in the colon. Polyps were considered “same position” compared to colonsocopy finding if they were detected in the same colon segment. Polyps were considered “same morphology” if they presented similar features. Average total transit time was 73.2 ± 45.4 hours. There were no reports of capsule malfunction or damage which might have compromised the participants' safety. Conclusion: Safety evaluation of a novel, preparation-free, X-ray imaging capsule and correlation of clinical findings to colonoscopy has been performed. Quantitative ultra-low dose X-ray imaging and detection of polyps of different sizes and polyp types was achieved in the colon of human subjects. A multicenter study with this x-ray based imaging capsule CRC screening technology is now in progress.
Cardioactivity and solid-state structure of two 4-isoxazolyldihydropyridines related to the 4-aryldihydropyridine calcium-channel blockers (1988)

Diethyl 2,6-dimethyl-4-(5-ethyl-3-phenylisoxazol-4-yl)-1,4-dihydroyprid ine-3,5- dicarboxylate (5) and diethyl 2,6-dimethyl-4-(5-isopropyl-3-phenylisoxazol-4-yl)-1,4-dihydropyri dine-3,5- dicarboxylate (6) were synthesized, and their molecular structures were determined by X-ray crystallography. In compound 5, which has an ethyl group at the C5 position of the isoxazole ring, the deviation from planarity in the dihydropyridine (DHP) ring is the smallest of all known DHP derivatives. The dihedral angle between the aromatic ring (the isoxazole) and the DHP ring, which is approximately 90 degrees in similar biologically active dihydropyridines, is somewhat smaller (82.7 degrees and 85.2 degrees, respectively) in these two compounds. In both compounds, one of the ester groups is coplanar with the DHP ring while the other one is out of plane by 14.7 degrees (ethyl) and 18.8 degrees (isopropyl). Both 5 and 6 were found to be vasodilators in the Langendorff assay. The potency of 6 on cardiac flow was similar to that of nifedipine; however, that of 5 was considerably attenuated. Since isoxazolyl analogue 6 lacks the significant negative inotropic activity associated with nifedipine, 6 offers promise as an antihypertensive or antianginal agent.
Neuromuscular transmission as a function of motor unit size in patients with prior polimyelitis (1992)

We studied neuromuscular transmission in 16 patients with prior poliomyelitis by measuring single fiber electromyographic (SFEMG) jitter. This was compared with 3 indirect methods of assessing reinnervation: SFEMG fiber density, macro EMG, and the presence of fiber type grouping on muscle biopsy. In patients with acute poliomyelitis before the age of 10, there was a positive correlation between the extent of neuromuscular transmission impairment, demonstrated by increased SFEMG jitter, and the enlargement of the motor unit, as indicated by increased fiber density, increased macro EMG signals, and fiber type grouping on muscle biopsy. However, there was no correlation between any of these parameters and the presence or absence of new symptoms of weakness. These findings suggest that impaired neuromuscular transmission is most common in patients with prior poliomyelitis whose motor units have been maximally enlarged by axonal sprouting, but is independent of the presence or absence of new symptoms of weakness.
ChemInform Abstract: Synthesis and Evaluation of 6‐(Dibromomethyl)‐5‐nitropyrimidines as Potential Antitumor Agents. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Surgery for supraventricular tachycardia and congenital heart defects: long-term efficacy of the combined approach in adult patients (2016)

Surgical treatment of unresponsive supraventricular arrhythmia during concomitant cardiac surgery in ACHD is a safe and effective procedure. Freedom from arrhythmias recurrence is 75% after 6 years of follow-up. Long-term recurrence of arrhythmia in these patients seems to be strongly correlated to preoperative arrhythmia duration.
L-Lysine As Kidney Protectant In Targeted Alpha Therapy With 213Bi-DOTATATE (2015)

338 Objectives Kidney protectants, e.g. lysine and arginine, are generally used in peptide receptor radionuclide therapy to prevent nephrotoxicity, since the kidney is one of the most radiosensitive organs. Previous pharmacokinetic studies using 213Bi-DOTA-Tyr3-octreotate (213Bi-DOTATATE) showed high renal activity. In this study we used L-Lysine (Lys) to lower the renal activity to determine the effect of Lys on the maximum tolerated activity (MTA) after targeted alpha therapy with 213Bi-DOTATATE in non-tumor nude mice. Methods The influence of pre-treatment of Lys (35 mg, i.p. 2-10 min prior to the tracer) on renal kinetics was determined by BIOD at 10 and 60min i.v. p.i. of 213Bi-DOTATATE (4cohorts, n=5/cohort). To determine MTA, 213Bi-DOTATATE (7±1.5MBq/0.3nmol/injection) was given in multiple i.v. injections over 2, 3 and 4days, corresponding to 13MBq, 21MBq and 29MBq in animals w/wo pre-treatment of Lys, placebo received 0.3nmol DOTATATE daily for 4 consecutive days (7cohort, n=8/cohort). Animals were evaluated for 90days; blood was collected and neutrophil gelatinase-associated lipocalin (NGAL) was determined. Results Renal radioactivity following pre-treatment of Lys was 19.0±7.2%IA/g and 5.3±1.6%IA/g and without Lys was 28.9±7.2%IA/g and 16.0±2.5%IA/g at 10 and 60min p.i., respectively, leading to a 50% lower renal residence time for 213Bi-DOTATATE. The median survival in the 29MBq cohort without Lys was 24days. A median survival of >90days was found in all other cohorts. In the 21MBq with Lys cohort all animals survived, without Lys only 62.5% survived for 90days. A significant difference in NGAL levels was found between placebo and 29MBq cohort without pre-administration of Lys. Conclusions In animals pretreated with the renal protectant Lys, MTA was determined to be 18.6 to 24.2MBq 213Bi-DOTATATE. Lys is capable of reducing absorbed dose to the kidneys by 50%. Research Support This material is based upon work supported by the U.S. Department of Energy, Office of Science, Office of Biological and Environmental Research, and Dinse Stiftung.
Titanium nitride as a plasmonic material for visible and near-infrared wavelengths [erratum] (2013)

We correct an error in figure 6 of our manuscript [Opt. Mater. Express 2, 479 (2012)] showing the propagation length and confinement width of surface-plasmon-polariton on metal/air interface.