gebhart/patrepeval huggingface dataset:
The Effect of Cement Viscosity in Total Knee Arthroplasty (2012)

Aseptic loosening of the tibial implant remains one of the major reasons of failure in Total Knee Arthroplasty (TKA). Currently, there is no consensus on the role that cement viscosity at the time of application to the bone plays in ensuring the long-term success of the arthroplasty. The purpose of this study was to investigate the relationship between cement viscosity and aseptic loosening of tibial implants. Three cements (Depuy 2, Palacos R (high viscosity cements) and Simplex-P, a medium viscosity cement) were compared during TKA through radiographic analysis and mechanical loading tests using surrogate tibia. Cement penetration was measured from radiographs of the constructs and analyzed according to the Knee Society Total Knee Arthroplasty Roentgenographic Evaluation System. Simplex-P had the maximum cumulative penetration in seven zones in the mediolateral view, and three zones in antero-posterior view. Simplex exhibited maximum penetration in zone 7 in the antero-posterior view, and in zone 3 in the lateral view. For the mechanical tests the TKA constructs were subjected to cyclic compressive loading in the sagittal plane. Simplex-P had the smallest micro-motion in sagittal plane, the results were significant when compared to Palacos R. The consistently superior performance of Simplex-P suggests that cement viscosity does indeed play a role in arthroplasty success. These results have direct clinical relevance for TKA patients suffering from aseptic loosening.
High-Level Viremia in Adults and Children Infected with Human Immunodeficiency Virus: Relation to Disease Stage and CD4+ Lymphocyte Levels (1991)

Sixty-eight adults and nine children infected with human immunodeficiency virus type 1 (HIV-1) were evaluated consecutively for the presence and amount of cell-free infectious virus in their plasma. Viremia was detected in 18 of 68 adults and in five of nine children; titers ranged from 10 to 100,000,000 TCID/ml plasma. Among the adults, none of 19 asymptomatic patients, 4 of 34 AIDS-related complex patients, and 14 of 15 AIDS patients had cell-free infectious virus in their plasma. None of 35 adult subjects with CD4+ lymphocyte counts greater than 400/mm3 were viremic, whereas 3 of 17 with 200-400 CD4+ lymphocytes/mm3 and 15 of 16 individuals with less than 200 CD4+ lymphocytes/mm3 were plasma viremic. In contrast to adults, each of five children infected with HIV-1 in utero or during the perinatal period were plasma viremic regardless of their CD4+ lymphocytes counts (range, 42-2227/mm3), duration of infection, or clinical stage; however, children infected by HIV-1 at older ages were less frequently plasma viremic. Therapy with zidovudine led to a 10- to 10(6)-fold decline in plasma HIV-1 TCID in all eight subjects studied before and after treatment.
The founder R304*AIPmutation is prevalent in Irish acromegaly and gigantism patients as well as in the general population of Ireland (2015)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
NUIs for new worlds (2012)

Mobile phones constitute the most ubiquitous computing platform in the developing world, and for the past decade it has been focus of many research efforts within Human Computer Interaction for Development (HCI4D). HCI4D has matured through a series of previous HCI related conferences and workshops and a growing body of work have established it as subfield of its own [1][2][4][5][6].
Gabexate mesilate and antithrombin III for intraoperative anticoagulation in heparin pretreated patients (1999)

Thirty patients scheduled for elective myocardial revascularization and having undergone preoperative heparin treatment have been admitted to this prospective, randomized study. The aim of the study was to test two different strategies for preserving circulating antithrombin III (AT-III) during cardiopulmonary bypass. Patients in the control group (group C, n = 10) were treated with a standard heparinization (300 IU/kg). Patients in group A (n = 10) received the same management plus two doses of purified antithrombin III (1000 IU each). Patients in group GA received 200 IU/kg heparin and a continuous infusion of heparin (100 IU/kg/h) and gabexate mesilate (2 mg/kg/h) plus the same dose of antithrombin III as group A. Both group A and group GA demonstrated a preservation of circulating AT-III when compared to group C; this effect was more pronounced in group GA. The total heparin dosage was less in group GA than in groups A and C. Purified AT-III administration is recommended in heparin pretreated patients; the addition of gabexate mesilate to this protocol decreases the heparin requirement and increases the AT-III preservation.
STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain (2013)

Activation of STAT3 in cancers leads to gene expression promoting cell proliferation and resistance to apoptosis, as well as tumor angiogenesis, invasion, and migration. In the characterization of effects of ST3-H2A2, a selective inhibitor of the STAT3 N-terminal domain (ND), we observed that the compound induced apoptotic death in cancer cells associated with robust activation of proapoptotic genes. Using ChIP and tiling human promoter arrays, we found that activation of gene expression in response to ST3-H2A2 is accompanied by altered STAT3 chromatin binding. Using inhibitors of STAT3 phosphorylation and a dominant-negative STAT3 mutant, we found that the unphosphorylated form of STAT3 binds to regulatory regions of proapoptotic genes and prevents their expression in tumor cells but not normal cells. siRNA knockdown confirmed the effects of ST3-HA2A on gene expression and chromatin binding to be STAT3 dependent. The STAT3-binding region of the C/EBP-homologous protein (CHOP) promoter was found to be localized in DNaseI hypersensitive site of chromatin in cancer cells but not in nontransformed cells, suggesting that STAT3 binding and suppressive action can be chromatin structure dependent. These data demonstrate a suppressive role for the STAT3 ND in the regulation of proapoptotic gene expression in cancer cells, providing further support for targeting STAT3 ND for cancer therapy.
CD4 T Cells Promote CD8 T Cell Immunity at the Priming and Effector Site during Viral Encephalitis (2011)

CD4 T cell activation during peripheral infections not only is essential in inducing protective CD8 T cell memory but also promotes CD8 T cell function and survival. However, the contributions of CD4 T cell help to antiviral CD8 T cell immunity during central nervous system (CNS) infection are not well established. Encephalitis induced by the sublethal coronavirus JHMV was used to identify when CD4 T cells regulate CD8 T cell responses following CNS infection. Peripheral expansion of virus-specific CD8 T cells was impaired when CD4 T cells were ablated prior to infection but not at 4 days postinfection. Delayed CD4 T cell depletion abrogated CD4 T cell recruitment to the CNS but only slightly diminished CD8 T cell recruitment. Nevertheless, the absence of CNS CD4 T cells was associated with reduced gamma interferon (IFN-γ) and granzyme B expression by infiltrating CD8 T cells, increased CD8 T cell apoptosis, and impaired control of infectious virus. CD4 T cell depletion subsequent to CD4 T cell CNS migration restored CD8 T cell activity and virus control. Analysis of γc-dependent cytokine expression indicated interleukin-21 (IL-21) as a primary candidate optimizing CD8 T cell activity within the CNS. These results demonstrate that CD4 T cells play critical roles in both enhancing peripheral activation of CD8 T cells and prolonging their antiviral function within the CNS. The data highlight the necessity for temporally and spatially distinct CD4 T cell helper functions in sustaining CD8 T cell activity during CNS infection.
A novel piezoelectric driven laparoscopic instrument with multiple degree of freedom parallel kinematic structure (2009)

The development of a novel actuator driven laparoscopic instrument with parallel kinematic instrument tip serves to overcome the workspace restrictions of classic laparoscopic instruments and provides the surgeon multiple degrees of freedom (DOF) inside the patients body.
Candidate Phyla Radiation Roizmanbacteria From Hot Springs Have Novel and Unexpectedly Abundant CRISPR-Cas Systems (2019)

The Candidate Phyla Radiation (CPR) comprises a huge group of bacteria that have small genomes that rarely encode CRISPR-Cas systems for phage defense. Consequently, questions remain about their mechanisms of phage resistance and the nature of phage that infect them. The compact CRISPR-CasY system (Cas12d) with potential value in genome editing was first discovered in these organisms. Relatively few CasY sequences have been reported to date, and little is known about the function and activity of these systems in the natural environment. Here, we conducted a genome-resolved metagenomic investigation of hot spring microbiomes and recovered CRISPR systems mostly from Roizmanbacteria that involve CasY proteins that are divergent from published sequences. Within population diversity in the spacer set indicates current <i>in situ</i> diversification of most of the loci. In addition to CasY, some Roizmanbacteria genomes also encode large type I-B and/or III-A systems that, based on spacer targeting, are used in phage defense. CRISPR targeting identified three phage represented by complete genomes and a prophage, which are the first reported for bacteria of the Microgenomates superphylum. Interestingly, one phage encodes a Cas4-like protein, a scenario that has been suggested to drive acquisition of self-targeting spacers. Consistent with this, the Roizmanbacteria population that it infects has a CRISPR locus that includes self-targeting spacers and a fragmented CasY gene (fCasY). Despite gene fragmentation, the PAM sequence is the same as that of other CasY reported in this study. Fragmentation of CasY may avoid the lethality of self-targeting spacers. However, the spacers may still have some biological role, possibly in genome regulation. The findings expand our understanding of CasY diversity, and more broadly, CRISPR-Cas systems and phage of CPR bacteria.
Multipotent Vδ2-negative γδT-cells after CMV-reactivation in allogeneic stem cell transplantation (162.36) (2012)

Abstract Human cytomegalovirus (CMV) infections and relapse of disease remain major problems after allogeneic stem cell transplantation (allo-SCT). Great promise as an alternative strategy, with a potential use for very broad patient population, arises from the non-MHC-restricted target-recognition of cancer cells and virally-infected cells by γδT-cells. Therefore, we investigated the role of γδT-cells after allo-SCT and CMV infection. An increase in selectively Vδ1-positive γδT-cells was observed in CMV-reactivating patients from CMV-positive conventional donors. Even more important, γδT-cell expansions were also observed after CMV-negative cordblood transplantation. However, in contrast to expansions from CMV-positive donors, γδT-cells from cordblood donors did not only include Vδ1-positive but also Vδ3-positive cells. Expanded Vδ2-negative γδT-cells were not only able to lyse CMV-infected fibroblasts, but also to partially mature dendritic cells (DCs) and to kill primary leukemic blasts. CMV- and leukemia-reactivity were restricted to the same clonal population and separated from DC-maturation capacities of Vδ2-negative T-cells. Vδ2-negative γδTCRs selectively mediated anti-leukemia-reactivity. This makes CMV-reactive γδT-cells e.g. from cordblood donors as well as individual Vδ2-negative γδTCRs interesting candidates for adoptive immunotherapy strategies
Supplementary Data Figure 1 from Functional Silencing of <i>HSD17B2</i> in Prostate Cancer Promotes Disease Progression (2023)

&lt;p&gt;T and DHT metabolism in MDA-Pca-2b and LAPC4 cells.&lt;/p&gt;
Characteristics of Pentacene Thin Film Transistor with Al[sub 2]O[sub 3] Gate Dielectrics on Plastic Substrate (2007)

Pentacene organic thin-film transistors (OTFTs) were fabricated on a polyethersulfone (PES) substrate with an gate dielectric grown at by plasma enhanced atomic layer deposition. Due to the roughness of the surfaces, the OTFTs with of showed better performance compared to that with of . When OTFTs with a thick layer were fabricated on PES substrate, excellent electrical characteristics were obtained, including carrier mobility as large as , a subthreshold slope as low as /dec, and on-off current ratio as large as .
Repeatability of MR Elastography of Liver: A Meta-Analysis (2017)

Purpose To perform a meta-analysis to generate an estimate of the repeatability coefficient (RC) for magnetic resonance (MR) elastography of the liver. Materials and Methods A systematic search of databases was performed for publications on MR elastography during the 10-year period between 2006 and 2015. The identified studies were screened independently and were verified reciprocally by all authors. Two reviewers independently determined the percentage RC and effective sample size from each article. A forest plot was constructed of the percentage RC estimates from the 12 studies. Bootstrap 95% confidence intervals (CIs) were constructed for the summary percentage RCs. Results Twelve studies comprising 274 patients met the eligibility criteria and were included for analysis. A flow diagram of studies included according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was prepared for the inclusion and exclusion criteria. All studies included in the meta-analysis fulfilled four or more of the seven categories of the Quality Assessment of Diagnostic Accuracy Studies (QUADAS)-2. The estimated summary RC was 22% (95% CI: 16.1%, 28.2%). The three main sources for this heterogeneity were the trained versus untrained operator drawing contours to choose regions of interest, the time between two replicate examinations, and, finally, the field strength of the MR imaging unit. The RC estimates tended to be higher for studies that did not use a well-trained operator, those with 1.5-T field strength imaging units, and those with longer time intervals between examinations. Conclusion The meta-analysis results provide the basis for the following draft longitudinal Quantitative Imaging Biomarkers Alliance MR elastography claim: A measured change in hepatic stiffness of 22% or greater, at the same site and with use of the same equipment and acquisition sequence, indicates that a true change in stiffness has occurred with 95% confidence. <sup>©</sup> RSNA, 2017.
Distributed feedback laser biosensor noise reduction (2012)

We report on a signal processing approach that enables detection of lasing wavelength shifts as small as Δλ~1.5pm from a distributed feedback laser biosensor (DFBLB) fabricated upon a plastic substrate and incorporated into microplates.
Image-Based Refocusing of Dual-Mode Ultrasound Arrays (DMUAs) in the Presence of Strongly Scattering Objects (2009)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation John R. Ballard, Andrew J. Casper, Yayun Wan, Emad S. Ebbini; Image‐Based Refocusing of Dual‐Mode Ultrasound Arrays (DMUAs) in the Presence of Strongly Scattering Objects. AIP Conf. Proc. 14 April 2009; 1113 (1): 13–17. https://doi.org/10.1063/1.3131400 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Architectural fabrication of tensile structures with flying machines (2013)

The paper presents a manufacturing process for the erection of tensile structures with flying robots. Analogies are drawn to existing methods of aerial construction and robotic fabrication in architecture. Firstly, we describe a set of aerial building instructions for the vehicles, such as an assembly of a node and the erection of a link. Secondly, we investigate combinations of these instructions as prototypical structural arrangements and identify distinct characteristics for architectural production.
Toll-like receptor 4 is a master regulator for colorectal cancer growth under high-fat diet by programming cancer metabolism (2021)

Although high-fat diet (HFD) has been implicated in the development of colorectal cancer (CRC), the critical signaling molecule that mediates the cancer growth is not well-defined. Identifying the master regulator that controls CRC growth under HFD can facilitate the development of effective therapeutics for the cancer treatment. In this study, the global lipidomics and RNA sequencing data show that, in the tumor tissues of CRC-bearing mouse models, HFD not only increases tumor weight, but also the palmitic acid level and TLR4 expression, which are reduced when HFD is replaced by control diet. These concomitant changes suggest the roles of palmitic acid and TLR4 in CRC growth. Subsequent studies show that palmitic acid regulates TLR4 expression in PU.1-dependent manner. Knockdown of PU.1 or mutations of PU.1-binding site on TLR4 promoter abolish the palmitic acid-increased TLR4 expression. The role of palmitic acid/PU.1/TLR4 axis in CRC growth is further examined in cell model and animal models that are fed either HFD or palmitic acid-rich diet. More importantly, iTRAQ proteomics data show that knockdown of TLR4 changes the metabolic enzyme profiles in the tumor tissues, which completely abolish the HFD-enhanced ATP production and cancer growth. Our data clearly demonstrate that TLR4 is a master regulator for CRC growth under HFD by programming cancer metabolism.
Farewell Wilfred (2015)

It is with great sadness that we announce the untimely death of our friend and colleague, Wilfred Röling, on September 25th. Wilfred was a truly inspirational scholar active in a range of topics within environmental microbiology and microbial biotechnology, and was one of only a handful of researchers worldwide able to effectively combine wet and in silico science. The loss to scholarly endeavour of his enormous potential is tragic. His dedication and generosity as an Editorial Board Member of this Journal was exemplary and his reviews have seriously elevated the quality of many submitted papers, accepted or not by the Journal. He was one-of-a-kind and we shall all miss him and his council. Our thoughts are with his family, friends and colleagues at this difficult time.
Safety and Efficacy of Surgical Resection of Unruptured Low-grade Arteriovenous Malformations From the Modern Decade (2015)

ARUBA, A Randomized Trial of Unruptured Brain Arteriovenous MalformationsbAVM, brain arteriovenous malformationmRS, modified Rankin Scale.
Extraordinary optical transmission in the ultraviolet region through aluminum hole arrays (2006)

We investigated the extraordinary optical transmission phenomenon in the UV range by fabricating large-area, free-standing aluminum hole arrays using extreme UV interference lithography and shadow thermal evaporation. Transmission spectra show strong peaks in the UV region resulting from both surface plasmon polariton and localized surface plasmon excitations. The results indicate that the high plasmon frequency of Al is directly responsible for the presence of strong resonance peaks in the UV region, which supports the role of plasmonic phenomena in the extraordinary transmission. The simple fabrication method enables large-area production of such structures for research and industrial production purposes.
Role of circulating endotoxin and interleukin-6 in the ACTH and corticosterone response to intraperitoneal LPS (1997)

Peripheral administration of lipopolysaccharide (LPS) may activate the hypothalamus-pituitary-adrenal (HPA) axis by way of both neural and humoral mechanisms. We have investigated whether biologically active endotoxin appears in the general circulation after intraperitoneal administration of LPS (5 or 100 micrograms/kg) to rats and whether this is a prerequisite for activation of this HPA axis. Within 15 min, endotoxin appeared in the general circulation, whereas elevations of plasma adrenocorticotropic hormone (ACTH), corticosterone, and interleukin (IL)-6 concentrations were not detected until 90 min after LPS injection. At this time, a marked interindividual variation was observed in plasma concentrations of endotoxin, ACTH, corticosterone, and IL-6. Elevated levels of plasma endotoxin were associated with elevated levels of ACTH, corticosterone, and IL-6. Intravenous administration of the LPS antagonist cationic antimicrobial protein 18 (5 mg/kg), which did not affect cytokine production in the peritoneal cavity, markedly reduced plasma ACTH, corticosterone, and IL-6 levels after 5 micrograms/kg LPS. Our results suggest that circulating endotoxin is required for the activation of the HPA axis. They also favor a role for circulating IL-6 in this response.
Computer‐assisted knee anterior cruciate ligament reconstruction: First clinical tests (1995)

Anterior cruciate ligament reconstruction is a delicate task. The procedure of choice is the patellar tendon bone autograft, but an anisometric position of this tendon often leads to failure. We propose a method that allows positioning of the central part of the ligament graft at the least anisometric sites. The system uses a workstation and a three-dimensional optical localizer to create images that represent knee kinematics. The surgeon uses these images to guide the surgery. This technique has been validated on eight cadavers and 12 patients. J Image Guid Surg 1:59-64 (1995). © 1995 Wiley-Liss, Inc.
Buckling of Magnetically Formed Filler Fiber Columns Under Compression Increases Thermal Resistance of Soft Polymer Composites (2018)

Thermally conductive soft composites are in high demand, and aligning the fill material is a potential method of enhancing their thermal performance. In particular, magnetic alignment of nickel particles has previously been demonstrated as an easy and effective way to improve directional thermal conductivity of such composites. However, the effect of compression on the thermal performance of these materials has not yet been investigated. This work investigates the thermal performance of magnetically aligned nickel fibers in a soft polymer matrix under compression. The fibers orient themselves in the direction of the applied magnetic field and align into columns, resulting in a 3× increase in directional thermal conductivity over unaligned composites at a volume fraction of 0.15. Nevertheless, these aligned fiber columns buckle under strain resulting in an increase in the composite thermal resistance. These results highlight potential pitfalls of magnetic filler alignment when designing soft composites for applications where strain is expected such as thermal management of electronics.
ATM support in a transparent network (2003)

It is shown how the variable size packet, source routing design on which the plaNET system was originally based is easily extended to provide support for ATM (asynchronous transfer mode) cells. The simultaneous support of various routing modes and packet formats is examined, mostly from the point of view of the necessary additional hardware and functionality. In particular, the components and processing needed to transparently support and take advantage of ATM in a plaNET network are examined. A major conclusion is that it is possible to combine the best attributes of variable size packets, source routing, cell routing, etc., without adding significantly to the cost of the network.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>