gebhart/patrepeval huggingface dataset:
The Stereochemistry of Complex Inorganic Compounds. XVII. The Stereochemistry of Hexadentate Ethylenediaminetetraacetic Acid Complexes - Correction (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Stereochemistry of Complex Inorganic Compounds. XVII. The Stereochemistry of Hexadentate Ethylenediaminetetraacetic Acid Complexes - CorrectionDaryle Busch and John Bailar, JrCite this: J. Am. Chem. Soc. 1953, 75, 24, 6363Publication Date (Print):December 1, 1953Publication History Published online10 July 2002Published inissue 1 December 1953https://pubs.acs.org/doi/10.1021/ja01120a654https://doi.org/10.1021/ja01120a654research-articleACS PublicationsRequest reuse permissionsArticle Views18Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Resistive Schmitt-Trigger Logic and High-Performance Digital Cell Library for Flexible Organic Thin-Film Transistor Technologies (2022)

&lt;p&gt;A resistive Schmitt-trigger (RST) logic is proposed. Based on this architecture, a digital cell library was designed, and basic logic-gate architectures, ring oscillators, edge-sensitive D-type flip-flops and a pad-driver cell were fabricated using low-voltage p-channel organic thin-film transistors (TFT) and integrated thin-film carbon resistors on flexible polymeric substrates. Theoretical analysis and experimental characterization of the RST logic architecture indicate improved stability against device-parameter mismatch and charge-carrier-mobility degradation. A small-signal gain of 83 dB and a noise margin of 92 % of half the supply voltage have been measured. Owing to the intrinsic positive-feedback loop of the RST logic, the design of the D-flip-flop enables a substantially smaller footprint and a considerably lower energy dissipation compared to previously reported unipolar organic-TFT-based D-flip-flops.&lt;/p&gt;
Towards 3D Human Pose Estimation in the Wild: a Weakly-supervised Approach (2017)

In this paper, we study the task of 3D human pose estimation in the wild. This task is challenging due to lack of training data, as existing datasets are either in the wild images with 2D pose or in the lab images with 3D pose. We propose a weakly-supervised transfer learning method that uses mixed 2D and 3D labels in a unified deep neutral network that presents two-stage cascaded structure. Our network augments a state-of-the-art 2D pose estimation sub-network with a 3D depth regression sub-network. Unlike previous two stage approaches that train the two sub-networks sequentially and separately, our training is end-to-end and fully exploits the correlation between the 2D pose and depth estimation sub-tasks. The deep features are better learnt through shared representations. In doing so, the 3D pose labels in controlled lab environments are transferred to in the wild images. In addition, we introduce a 3D geometric constraint to regularize the 3D pose prediction, which is effective in the absence of ground truth depth labels. Our method achieves competitive results on both 2D and 3D benchmarks.
Recovery of hemoglobin oxygen saturation and intrinsic fluorescence with a forward-adjoint model (2005)

We present two forward-adjoint models for recovering intrinsic fluorescence spectra and hemoglobin oxygen saturation of turbid samples. The first fits measured diffuse reflectance spectra to obtain the absorption and scattering spectra of the medium, and these are then used to correct distortions imposed on the fluorescence spectrum by absorption and scattering. The second fits only the measured fluorescence spectrum to determine simultaneously the amplitudes of absorption and fluorescence basis spectra and scattering parameters. Both methods are validated with Monte Carlo simulations and experimentally in scattering phantoms containing nicotinamide adenine dinucleotide and human erythrocytes. Preliminary measurements from murine tumors in vivo are presented.
EMCCD-Based Detector for Time-Resolved X-Ray Diffraction and Scattering Studies of Biological Specimens (2006)

Third generation synchrotron sources such as the Advanced Photon Source (APS), Argonne, IL, are outstanding tools for X-ray diffraction and scattering studies of non-crystalline biological materials. However, these studies are hindered by the lack of detectors that provide multiple frames of detailed structural information on the millisecond time scale at the required high spatial resolution, and large active areas. Here we report the development of a cost effective detector for time-resolved small angle X-ray scattering (SAXS) using a cooled, fiberoptically coupled electron multiplying CCD (EMCCD), whose internal gain is selectable in real-time. The performance of the detector was evaluated using a Gd <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> S:Tb scintillator and was compared to a current state-of-the-art SAXS detector developed at Brandeis University. We also report our first results on the fabrication of a novel, microcolumnar, ZnSe(Te) scintillator that has a promise to provide very high emission efficiency of over 100,000 photons/MeV, high spatial resolution in excess of 10 lp/mm, and a fast decay time with virtually absent afterglow. Development of this scintillator will complement the EMCCD design, permitting the advances of a high spatial and temporal resolution, large area detector for time resolved applications.
Combined Compression and Classification with Learning Vector Quantization (1998)

Combined compression and classification problems are becoming increasingly important in many applications with large amounts of sensory data and large sets of classes.These applications range from automatic target recognition (ATR) to medical diagnosis, speech recognition, and fault detection and identification in manufacturing systems.In this paper, we develop and analyze a learning vector quantization (LVQ) based algorithm for combined compression and classification.We show convergence of the algorithm using the ODE method from stochastic approximation.We illustrate the performance of our algorithm with some examples.
Synthesis of an Oxathiolane Drug Substance Intermediate Guided by Constraint-Driven Innovation (2020)

A new route was developed for construction of the oxathiolane intermediate used in the synthesis of lamivudine (3TC) and emtricitabine (FTC). We developed the presented route by constraining ourselves to low-cost, widely available starting materials-we refer to this as supply-centered synthesis. Sulfenyl chloride chemistry was used to construct the framework for the oxathiolane from acyclic precursors. This bond construction choice enabled the use of chloroacetic acid, vinyl acetate, sodium thiosulfate, and water to produce the oxathiolane.
Supplementary Tables 1-2 from Assessing the Clinical Role of Genetic Markers of Early-Onset Prostate Cancer among High-Risk Men Enrolled in Prostate Cancer Early Detection (2023)

&lt;p&gt;PDF file - 95K&lt;/p&gt;
Light Extraction from Organic Light Emitting Diodes Using Chemically Etched Glass Substrates (2012)

We have manufactured highly efficient OLED devices fabricated on chemically etched glass substrates. The external quantum efficiency of the OLED devices with the etched glass substrates was increased by 5-27% in comparison with the reference flat glass substrate. Surface morphology, such as indented patterns, significantly affected the external luminance efficiency. A clean surface and the presence of smooth bent edges of indented patterns were found to be important for improving the external luminous efficacy.
Microwave dissipation in arrays of single-wall carbon nanotubes (2006)

The transmission and reflection scattering parameters of arrays of single-wall carbon nanotubes (SWCNTs) directly assembled onto coplanar waveguides (CPWs) have been measured from 0.01to50GHz at room temperature. Typical arrays consisted of roughly ∼103 SWCNTs aligned parallel to the electric field polarization of the propagating field. Scattering parameters were measured on CPWs both before and after SWCNT assembly, allowing separation of SWCNT effects from the characteristics of the bare CPWs. Additional frequency-dependent power dissipation was consistently observed after assembly of SWCNT arrays.
Transient Gastric Irritation in the Neonatal Rats Leads to Changes in Hypothalamic CRF Expression, Depression- and Anxiety-Like Behavior as Adults (2011)

The present results suggest that transient gastric irritation in the neonatal period can induce a long lasting increase in depression- and anxiety-like behaviors, increased expression of CRF in the hypothalamus, and an increased sensitivity of HPA axis to stress. The depression-like behavior may be mediated by the CRF1 receptor. These findings have significant implications for the pathogenesis of psychological co-morbidity in patients with functional bowel disorders.
DAC-Less and DSP-Free 112 Gb/s PAM-4 Transmitter Using Two Parallel Electroabsorption Modulators (2018)

Four-level pulse amplitude modulation (PAM-4) is widely regarded as the modulation format of choice for the next generation of 400 gigabit Ethernet short-reach optical transceiver. However, generating and receiving PAM-4 at line rates of 112 Gb/s has proven challenging, without relying on power-hungry tools as digital signal processing and digital-to-analog converters, as it requires linearity from the E/O-components in the link and/or predistortion techniques. Moving the binary to multilevel conversion to the optical domain would greatly relax these requirements. Electroabsorption-based transceivers would be ideally suited for this type of data center interconnects as they are capable of combining low-power and high bandwidth operation with a very compact layout, removing the need for large travelling wave structures and dedicated 50 Ω terminations. In this paper, we present a novel transmitter topology for generating PAM-4 using two binary-driven electroabsorption modulators in parallel. Using this approach, we achieve superior performance with respect to a single, but identical multilevel-driven EAM. Finally, we demonstrate the first silicon-based modulator capable of transmitting single-lane 112 Gb/s PAM-4 over 2 km of standard single-mode fiber without any electrical digital-to-analog converter, DSP, or long transmission line structures and terminations.
Parallel Decreases in the Expression of Receptors for Insulin and Insulin-like Growth Factor I in a Mutant Human Fibroblast Line (1983)

The receptors for insulin and the insulin-like growth factor (IGF) I are two structurally homologous disulfide-linked multisubunit complexes of apparent Mr = 350,000. The similar subunit structures of these two types of receptors suggested that their genetic expression might be affected by common genetic defects. We have examined this possibility in an insulin-resistant, diabetic patient who exhibits decreased insulin binding activity. The receptors for IGF-I and insulin in skin fibroblasts from this patient were affinity labeled with 125I-IGF-I and 125I-insulin, respectively, and visualized by electrophoresis and autoradiography in polyacrylamide gels. Control fibroblasts exhibited the usual affinity labeling of the disulfide-linked Mr = 350,000 insulin and IGF-I receptor structures. The intensity of labeling of both receptor types in the patient's fibroblasts was less than in control fibroblasts. Binding data indicated that this decrease is due to a decreased receptor number with little or no decrease in affinity for the respective ligands. The high-affinity IGF-II receptor in fibroblasts affinity labeled with 125I-IGF-II or 125I-IGF-I consists of a single polypeptide not disulfide linked to any other membrane component. The molecular size and intensity of labeling of the IGF-II receptor in the patient's fibroblasts were unaltered when compared with those of controls. These observations suggest that a common genetic defect alters the expression of the homologous receptor structures for insulin and IGF-I.
Supplementary Table 5 from Global Evaluation of Eph Receptors and Ephrins in Lung Adenocarcinomas Identifies EphA4 as an Inhibitor of Cell Migration and Invasion (2023)

&lt;p&gt;PDF file, 85K, Distribution of Eph receptors gene mutations in NSCLC.&lt;/p&gt;
Electronic spectroscopy of jet-cooled half-sandwich organometallic free radicals. 1. Laser-induced fluorescence study of the cyclopentadienyl complexes of zinc and cadmium (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic spectroscopy of jet-cooled half-sandwich organometallic free radicals. 1. Laser-induced fluorescence study of the cyclopentadienyl complexes of zinc and cadmiumEric S. J. Robles, Andrew M. Ellis, and Terry A. MillerCite this: J. Phys. Chem. 1992, 96, 8, 3247–3258Publication Date (Print):April 1, 1992Publication History Published online1 May 2002Published inissue 1 April 1992https://pubs.acs.org/doi/10.1021/j100187a015https://doi.org/10.1021/j100187a015research-articleACS PublicationsRequest reuse permissionsArticle Views63Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
DNA Hybrids Stabilized by Heterologies (1999)

The double D-loop DNA hybrid contains four DNA strands following hybridization of two RecA protein coated complementary single-stranded DNA probes with a homologous region of a double-stranded DNA target. A remarkable feature of the double D-loop DNA hybrids is their kinetic stabilities at internal sites within linear DNA targets after removal of RecA protein from hybrids. We report here that heterologous DNA inserts in one or both probe strands affect the kinetic stability of protein-free double D-loop hybrids. DNA heterologies normally distort DNA-DNA hybrids and consequently accelerate hybrid dissociation. In contrast, heterologous DNA inserts impede dissociation of double D-loops, especially when the insert sequences interact with each other by DNA base pairing. We propose a mechanism for this kinetic stabilization by heterologous DNA inserts based on the hypothesis that the main pathway of dissociation of double D-loop DNA hybrids is a DNA branch migration process involving the rotation of both probe-target duplexes in the hybrids. Heterologous DNA inserts constrain rotation of probe-target duplexes and consequently impede hybrid dissociation. Potential applications of the stabilized double D-loops for gene targeting are discussed.
Design and Implementation of the PULSAR Programming System for Large Scale Computing (2017)

The objective of the PULSAR project was to design a programming model suitable for large scale machines with complex memory hierarchies, and to deliver a prototype implementation of a runtime system supporting that model. PULSAR tackled the challenge by proposing a programming model based on systolic processing and virtualization. The PULSAR programming model is quite simple, with point-to-point channels as the main communication abstraction. The runtime implementation is very lightweight and fully distributed, and provides multithreading, message-passing and multi-GPU offload capabilities. Performance evaluation shows good scalability up to one thousand nodes with one thousand GPU accelerators.
Scaling of Polymer Solutions as a Quantitative Tool (2021)

Knowledge of interaction parameters and Kuhn length for a polymer/solvent pair is a foundation of polymer physics of synthetic and biological macromolecules. Here, we demonstrate how to obtain these parameters from the concentration dependence of solution viscosity. The centerpiece of this approach is the scaling relationship between solution correlation length (blob size) ξ = lgν/B and the number of monomers per correlation blob g for polymers with monomer projection length l. The values of parameter B and exponent v are determined by solvent quality for the polymer backbone, chain Kuhn length, and types and strength of monomer–monomer and monomer–solvent interactions. Parameter B assumes values Bg, Bth, and 1 for exponent v = 0.588, 0.5, and 1, respectively. In particular, we take advantage of the linear relationship between specific viscosity ηsp in the unentangled (Rouse) regime and the number of correlation blobs Nw/g per chain with the weight average degree of polymerization, Nw, and g = B3/(3ν – 1)(cl3)1/(1 – 3ν) as a function of monomer concentration, c, and the corresponding B parameter. The values of the B parameters are extracted from the plateaus of normalized specific viscosity ηsp(c)/Nw(cl3)1/(3ν – 1) or their locations as a function of the monomer concentration c in different solution regimes. The extension of the approach to entangled polymer solutions provides a means to obtain the chain packing number, Pe, and to complete the set of parameters {Bg, Bth, Pe} (a system “fingerprint”) uniquely describing static and dynamic solution properties of a polymer/solvent pair. This approach is illustrated for solutions of poly(ethylene oxide) in water, poly(styrene) in tetrahydrofuran and toluene, poly(methyl methacrylate) in ionic liquids, and sodium carboxymethylcellulose in water at high salt concentrations.
Angular resolved light scattering for discriminating among marine picoplankton: modeling and experimental measurements (2006)

In order to assess the capability to optically identify small marine microbes, both simulations and experiments of angular resolved light scattering (ARLS) were performed. After calibration with 30-nm vesicles characterized by a nearly constant scattering distribution for vertically polarized light (azimuthal angle=90 degrees ), ARLS from suspensions of three types of marine picoplankton (two prokaryotes and one eukaryote) in seawater was measured with a scattering device that consisted of an elliptical mirror, a rotating aperture, and a PMT. Scattered light was recorded with adequate signal-to-noise in the 40-140 degrees . Simulations modeled the cells as prolate spheroids with independently measured dimensions. For the prokaryotes, approximated as homogeneous spheroids, simulations were performed using the RM (Rayleigh-Mie) - I method, a hybrid of the Rayleigh-Debye approximation and the generalized Lorentz-Mie theory. For the picoeukaryote, an extended RM - I method was developed for a coated spheroid with different shell thickness distributions. The picoeukaryote was then modeled as a coated sphere with a spherical core. Good overall agreements were obtained between simulations and experiments. The distinctive scattering patterns of the different species hold promise for an identification system based on ARLS.
Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ) Agonist for Use in Treating Cancer (2021)

Retinoic acid receptor-related orphan receptor γ (RORc, RORγ, or NR1F3) is the nuclear receptor master transcription factor that drives the function and development of IL-17-producing T helper cells (Th17), cytotoxic T cells (Tc17), and subsets of innate lymphoid cells. Activation of RORγ<sup>+</sup> T cells in the tumor microenvironment is hypothesized to render immune infiltrates more effective at countering tumor growth. To test this hypothesis, a family of benzoxazines was optimized to provide LYC-55716 (<b>37c</b>), a potent, selective, and orally bioavailable small-molecule RORγ agonist. LYC-55716 decreases tumor growth and enhances survival in preclinical tumor models and was nominated as a clinical development candidate for evaluation in patients with solid tumors.
Evaluation of the contamination removal capability and multilayer degradation in various cleaning methods (2010)

In this test, we evaluated the carbon contamination removal capabilities of various kinds of cleaning methods. And we also evaluated the degradation of multilayer (with capping layer) caused by the cleaning process. In the contamination removal test, the contamination was formed by a synchrotron irradiation. And in the degradation test, we evaluated Ru-capping layer and Si-capping layer. In the contamination removal test, the reflectivity recovery was confirmed in all cleaning conditions that were evaluated. However, there were differences among the reflectivity recoveries. In particular, plasma cleaning showed high removal capability. In VUV/O3 cleaning, the oxygen concentration influenced the contamination removal capability. In Si-capping layer, none of the cleaning conditions exhibited any significant reflectance change. On the other hand, in Ru-capping layer, a decrease in reflectance was noticed in VUV/O3 cleaning with an oxygen concentration of 500ppm. In a comparison between Ru-capping layer and Si-capping layer, no significant difference was noticed in SPM cleaning, VUV/O3 with oxygen concentration 45ppm, and in plasma with N2/H2 gas condition.
Deriving stopping rules for the probabilistic Hough transform by sequential analysis (2002)

In probabilistic Hough transforms computation is accelerated by polling instead of voting. A small part of the data set is selected at random and used as input to the algorithm. Most probabilistic Hough algorithms use a fixed poll size. It has been experimentally demonstrated that adaptive termination of voting can lead to improved performance in terms of the error rate versus average poll size tradeoff. However, the lack of a solid theoretical foundation made general performance evaluation and optimal design of adaptive stopping rules nearly impossible. In this paper we suggest two novel adaptive stopping rules in the framework of the statistical theory of sequential hypothesis testing. The performance of the suggested stopping rules is verified using real images. It is shown that the extension suggested in this paper to Wald's one sided alternative sequential test (1947) performs better than previously available adaptive (or fixed) stopping rules.