gebhart/patrepeval huggingface dataset:
Quasi-Optimal Subcarrier Selection Dedicated for Localization With Multicarrier-Based Signals (2018)

The objective of this paper is to design dedicated probing signals for localization based on orthogonal multicarriers that attain the lowest value of the possible fundamental limits. The proposed scheme named Quasi-Optimal Subcarrier Selection (QOSS) attempts to generate the probing signals in positioning systems by minimizing the Cramer-Rao lower bound of range estimation in nonoverlapping multipath channels instead, which do indirectly depress the performance bounds in overlapping multipath channels to a certain extent. Based on the optimization of power allocation on orthogonal subcarriers, two kinds of QOSS signals are proposed for: 1) basestation (BS)-based localization networks where mobile station (MS) transmits to all BSs, and 2) MS-based localization networks where multiple BSs simultaneously transmit to the MS. Two adaptive search algorithms have been presented to generate the QOSS signal for MS-based localization networks. The fundamental limits of both QOSS signals are theoretically derived, the close relationship between the bound of range estimation and that of localization is disclosed and the lower bound of position dilution of precision is further obtained. Numerical results and experiments demonstrate our proposed theory.
Data from Epigenetic Reprogramming with Antisense Oligonucleotides Enhances the Effectiveness of Androgen Receptor Inhibition in Castration-Resistant Prostate Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;Advanced prostate cancer initially responds to androgen deprivation therapy (ADT), but the disease inevitably recurs as castration-resistant prostate cancer (CRPC). Although CRPC initially responds to abiraterone and enzalutamide, the disease invariably becomes nonresponsive to these agents. Novel approaches are required to circumvent resistance pathways and to extend survival, but the mechanisms underlying resistance remain poorly defined. Our group previously showed the histone lysine-&lt;i&gt;N&lt;/i&gt;-methyltransferase EZH2 to be overexpressed in prostate cancer and quantitatively associated with progression and poor prognosis. In this study, we screened a library of epigenetic inhibitors for their ability to render CRPC cells sensitive to enzalutamide and found that EZH2 inhibitors specifically potentiated enzalutamide-mediated inhibition of proliferation. Moreover, we identified antisense oligonucleotides (ASO) as a novel drug strategy to ablate EZH2 and androgen receptor (AR) expression, which may have advantageous properties in certain settings. RNA-seq, chromatin immunoprecipitation sequencing, and assay for transposase-accessible chromatin using sequencing demonstrated that EZH2 inhibition altered the AR cistrome to significantly upregulate AR signaling, suggesting an enhanced dependence of CRPC cells on this pathway following inhibition of EZH2. Combination treatment with ASO targeting EZH2 and AR transcripts inhibited prostate cancer cell growth &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; better than single agents. In sum, this study identifies EZH2 as a critical epigenetic regulator of ADT resistance and defines ASO-based cotargeting of EZH2 and AR as a promising strategy for the treatment of CRPC.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Significance:&lt;/b&gt; Simultaneous targeting of lysine methyltransferase EZH2 and the AR with ASO proves a novel and effective therapeutic strategy in patients with CRPC. &lt;i&gt;Cancer Res; 78(20); 5731–40. ©2018 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Untersuchungen über Mischkrystallbildung in Lösungen. III. Die Bildung ternärer Mischkrystalle im System K· + NH4· + Cl′ + Br′ + H2O (1944)

Abstract 1. Das vollständige Löslichkeitsdiagramm des quaternären Systems wird für 25° aufgestellt. Es zeigt sich, dass in diesem System nur zwei Bodenkörpertypen auftreten und dass daher das Diagramm aus zwei Feldern besteht, die sich in einer Zweisalzlinie schneiden.
Outcomes after major cancer surgery: Can we predict them using parsimonious models? (2018)

811 Background: Major cancer surgery is associated with significant risks of morbidity/mortality. Retrospective studies have demonstrated an association between Surgical Apgar Score (SAS) and postoperative risk of serious complications (SC). This study prospectively evaluated the predictive value of SAS to predict SC, as well as other adverse postoperative outcomes and length of stay (LOS), both singly and in combination with parsimonious measures of “fitness for surgery” (American Society of Anesthesiology [ASA] classification) and surgical complexity (work relative value units [wRVU]). Methods: Demographic, comorbidity, procedure, intraoperative, and outcome data was collected prospectively for 442 cancer patients undergoing elective major surgery between 2014-17. ASA and wRVU were assigned preoperatively; SAS was calculated postoperatively. Logistic regression was used to analyze association of ASA versus (vs) wRVU vs SAS vs ASA/wRVU/SAS (combined) with perioperative outcomes, including SC, return to the operating room (ROR), not being discharged to home, and unplanned readmission; areas under receiver operator characteristic curves were calculated to assess predictive accuracy. Accelerated failure time models were used to analyze associations with LOS and compared using Harrell’s concordance index. Results: Predictive accuracy of SAS for SC was modest (AUC0.655) and not improved when controlling for ASA and wRVU (both of which had poor predictive accuracy for SC). Both wRVU (AUC 0.634) and SAS (AUC 0.663) had modest predictive accuracies for ROR, whereas the predictive accuracy of ASA (AUC 0.749) surpassed that of wRVU (AUC 0.630) for not being discharged to home. All 3 measures were poor at predicting readmission. In contrast, the predictive accuracy of ASA, wRVU, and SAS for LOS was highest when combined (AUC 0.699). Conclusions: Commonly used, simple measures of comorbidity/functional status and surgical complexity can help predict risk of ROR and not being discharged to home (respectively), whereas only SAS has sufficient (albeit modest) discriminatory ability to predict risk of SC. All three measures are too coarse to predict unplanned readmission, but when used in combination, can help predict LOS.
Multisite Technical and Clinical Performance Evaluation of Quantitative Imaging Biomarkers from 3D FDG PET Segmentations of Head and Neck Cancer Images (2020)

Quantitative imaging biomarkers (QIBs) provide medical image-derived intensity, texture, shape, and size features that may help characterize cancerous tumors and predict clinical outcomes. Successful clinical translation of QIBs depends on the robustness of their measurements. Biomarkers derived from positron emission tomography images are prone to measurement errors owing to differences in image processing factors such as the tumor segmentation method used to define volumes of interest over which to calculate QIBs. We illustrate a new Bayesian statistical approach to characterize the robustness of QIBs to different processing factors. Study data consist of 22 QIBs measured on 47 head and neck tumors in 10 positron emission tomography/computed tomography scans segmented manually and with semiautomated methods used by 7 institutional members of the NCI Quantitative Imaging Network. QIB performance is estimated and compared across institutions with respect to measurement errors and power to recover statistical associations with clinical outcomes. Analysis findings summarize the performance impact of different segmentation methods used by Quantitative Imaging Network members. Robustness of some advanced biomarkers was found to be similar to conventional markers, such as maximum standardized uptake value. Such similarities support current pursuits to better characterize disease and predict outcomes by developing QIBs that use more imaging information and are robust to different processing factors. Nevertheless, to ensure reproducibility of QIB measurements and measures of association with clinical outcomes, errors owing to segmentation methods need to be reduced.
Deep Reinforcement Learning for Adaptive Caching in Hierarchical Content Delivery Networks (2019)

Caching is envisioned to play a critical role in next-generation content delivery infrastructure, cellular networks, and Internet architectures. By smartly storing the most popular contents at the storage-enabled network entities during off-peak demand instances, caching can benefit both network infrastructure as well as end users, during on-peak periods. In this context, distributing the limited storage capacity across network entities calls for decentralized caching schemes. Many practical caching systems involve a parent caching node connected to multiple leaf nodes to serve user file requests. To model the two-way interactive influence between caching decisions at the parent and leaf nodes, a reinforcement learning (RL) framework is put forth. To handle the large continuous state space, a scalable deep RL approach is pursued. The novel approach relies on a hyper-deep Q-network to learn the Q-function, and thus the optimal caching policy, in an online fashion. Reinforcing the parent node with ability to learn-and-adapt to unknown policies of leaf nodes as well as spatio-temporal dynamic evolution of file requests, results in remarkable caching performance, as corroborated through numerical tests.
Novel Spin–Orbit Torque Generation at Room Temperature in an All‐Oxide Epitaxial La0.7Sr0.3MnO3/SrIrO3 System (2021)

Spin-orbit torques (SOTs) that arise from materials with large spin-orbit coupling offer a new pathway for energy-efficient and fast magnetic information storage. SOTs in conventional heavy metals and topological insulators are explored extensively, while 5d transition metal oxides, which also host ions with strong spin-orbit coupling, are a relatively new territory in the field of spintronics. An all-oxide, SrTiO<sub>3</sub> (STO)//La<sub>0.7</sub> Sr<sub>0.3</sub> MnO<sub>3</sub> (LSMO)/SrIrO<sub>3</sub> (SIO) heterostructure with lattice-matched crystal structure is synthesized, exhibiting an epitaxial and atomically sharp interface between the ferromagnetic LSMO and the high spin-orbit-coupled metal SIO. Spin-torque ferromagnetic resonance (ST-FMR) is used to probe the effective magnetization and the SOT efficiency in LSMO/SIO heterostructures grown on STO substrates. Remarkably, epitaxial LSMO/SIO exhibits a large SOT efficiency, ξ<sub>||</sub> = 1, while retaining a reasonably low shunting factor and increasing the effective magnetization of LSMO by ≈50%. The findings highlight the significance of epitaxy as a powerful tool to achieve a high SOT efficiency, explore the rich physics at the epitaxial interface, and open up a new pathway for designing next-generation energy-efficient spintronic devices.
A novel role for the extracellular matrix glycoprotein‐Tenascin‐X in gastric function (2019)

Tenascin-X (TNX) is a glycoprotein that regulates tissue structure via anti-adhesive interactions with collagen in the extracellular matrix. TNX deficiency causes a phenotype similar to hypermobility Ehlers-Danlos syndrome involving joint hypermobility, skin hyperelasticity, pain and gastrointestinal dysfunction. Previously, we have shown that TNX is required for neural control of the bowel by a specific subtype of mainly cholinergic enteric neurones and regulates sprouting and sensitivity of nociceptive sensory endings in mouse colon. These findings correlate with symptoms shown by TNX-deficient patients and mice. We aimed to identify whether TNX is similarly present in neural structures found in mouse and human gastric tissue. We then determined whether TNX has a functional role, specifically in gastric motor and sensory function and nodose ganglia neurones. We report that TNX was present in calretinin-immunoreactive extrinsic nerve endings in mouse and human stomach. TNX deficient mice had accelerated gastric emptying and markedly increased vagal afferent responses to gastric distension that could be rescued with GABA<sub>B</sub> receptor agonist. There were no changes in nodose ganglia excitability in TNX deficient mice, suggesting that vagal afferent responses are probably the result of altered peripheral mechanosensitivity. In TNXB-deficient patients, significantly greater symptoms of reflux, indigestion and abdominal pain were reported. In the present study, we report the first role for TNX in gastric function. Further studies are required in TNX deficient patients to determine whether symptoms can be relieved using GABA<sub>B</sub> agonists.
Comparison of the "pad-open-short" and "open-short-load" deembedding techniques for accurate on-wafer RF characterization of high-quality passives (2005)

The impedance errors remaining after applying the industry standard "open-short," a "pad-open-short," and a "open-short-load" deembedding scheme on a 0.43-nH 20-GHz high-Q single-loop inductor test structure are investigated using real S-parameter data taken up to 50 GHz. Since the latter two deembedding schemes both correct for all parasitic elements of the test structures, they are, at least in principle, error free. The accuracy of the "open-short-load" deembedding scheme, however, critically depends on how well the reactive part of the load resistance is accounted for. This issue makes the more simple "pad-open-short" deembedding scheme an attractive choice because the required split between external and internal capacitances is easy to make, either based on process and layout information or from measurements done on a "pad" dummy structure
Subcritical to supercritical mixing (2008)

Liquid jet injection into a quiescent gaseous environment has been experimentally and analytically studied covering subcritical to supercritical conditions. The focus was placed on the influence that the surrounding gas pressure and temperature have on the jet breakup. Under subcritical conditions, the surrounding gas inertia and surface tension forces controlled this process with ligament formation from which the material broke off and the drops, later, formed. Decreasing surface tension influenced the jet surface behavior under transcritical conditions: Ligament formation was significantly reduced under these conditions with only occasional drop formation. Further increasing the pressure and temperature led to supercritical breakup modes. This manifested through a smoothening of the liquid-gas interface. Ligament formation was not observed under supercritical conditions; this indicated that surface tension did not play any role in the supercritical jet breakup. The experimental technique, using planar laser induced fluorescence, revealed important core jet structures previously undetected. A linear jet stability analysis was, then, performed to gain physical insight into the jet breakup mechanisms. The results showed good correlation with experimental results under subcritical mixing but failed to predict the transcritical and supercritical regimes.
Integrated genomic and transcriptional profiling identifies chromosomal loci with altered gene expression in cervical cancer (2008)

For a better understanding of the consequences of recurrent chromosomal alterations in cervical carcinomas, we integrated genome-wide chromosomal and transcriptional profiles of 10 squamous cell carcinomas (SCCs), 5 adenocarcinomas (AdCAs) and 6 normal controls. Previous genomic profiling showed that gains at chromosome arms 1q, 3q, and 20q as well as losses at 8q, 10q, 11q, and 13q were common in cervical carcinomas. Altered regions spanned multiple megabases, and the extent to which expression of genes located there is affected remains unclear. Expression analysis of these previously chromosomally profiled carcinomas yielded 83 genes with significantly differential expression between carcinomas and normal epithelium. Application of differential gene locus mapping (DIGMAP) analysis and the array CGH expression integration tool (ACE-it) identified hotspots within large chromosomal alterations in which gene expression was altered as well. Chromosomal gains of the long arms of chromosome 1, 3, and 20 resulted in increased expression of genes located at 1q32.1-32.2, 3q13.32-23, 3q26.32-27.3, and 20q11.21-13.33, whereas a chromosomal loss of 11q22.3-25 was related to decreased expression of genes located in this region. Overexpression of DTX3L, PIK3R4, ATP2C1, and SLC25A36, all located at 3q21.1-23 and identified by DIGMAP, ACE-it or both, was confirmed in an independent validation sample set consisting of 12 SCCs and 13 normal ectocervical samples. In conclusion, integrated chromosomal and transcriptional profiling identified chromosomal hotspots at 1q, 3q, 11q, and 20q with altered gene expression within large commonly altered chromosomal regions in cervical cancer.
On the applicability of the Fujisaki–Okamoto transformation to the BIKE KEM (2021)

The QC-MDPC code-based KEM BIKE is one of the Round-3 candidates of the NIST PQC standardization project. Its Round-2 specification document described variants claiming to have IND-CCA security. The security proof used the Fujisaki-Okamoto transformation and a decoder targeting a Decoding Failure Rate (DFR) of 2(-128) (for Level-1 security). However, several aspects needed to be amended in order for the IND-CCA proof to hold. The main issue is that using a decoder with DFR of 2(-128) does not necessarily imply that the underlying PKE is delta-correct with delta = 2(-128), as required. In this paper, we handle the necessary aspects to ensure the security claim is correct. In particular, we close the gap in the proof by defining the notion of message-agnostic PKE. We show that the PKEs underlying the BIKE versions are message-agnostic. This implies that BIKE with a decoder that has a sufficiently low DFR is also an IND-CCA KEM.
ChemInform Abstract: Me3(OMe)tBuXPhos: A Surrogate Ligand for Me4tBuXPhos in Palladium‐Catalyzed C—N and C—O Bond‐Forming Reactions. (2012)

Abstract The new and inexpensive phosphine promotes the Pd‐catalyzed arylation of nitrogen and oxygen nucleophiles and shows the same effectivity as Me 4 tBuXPhos.
Simple and secure mobile access under the flexible organization management (2004)

In business we often encounter a situation where two organizations in alliance organize a temporal inter-organizational group to accomplish joint-work. Ideally arbitrary subgroups of these organizations should be able to form a new subgroup with low cost even though these organizations are often run with different subnetwork management policies. In this paper, we propose simple, effortless and transparent mobile communication suitable for the cooperative working environments with protection against the outside attacks. A distinguished property of our approach is that we can achieve our goal without changing the existent router networks. Unlike Mobile IP, our system is more suitable for flexible access control among sub-networks.
Some Practical Aspects of Using VSP Interferometry in Horizontal Wells for Imaging Above and Below the Wellbore (2013)

With the increased number of horizontal wells being used to produce unconventional plays, there is a growing inventory of wells that can benefit from the use of interferometric processing methods. Seismic interferometry for VSPs in horizontal wells can move the surface shots to behave as if they are located at the positions of the receivers in the borehole. It removes the overburden travel path from the redatumed traces without using any velocity information or even surface shot statics. So an image can be made below the borehole using only the local velocity near the borehole. The added benefit of redatuming the shots into the borehole is that the upcoming reflected energy from changes in the lithology below the borehole can act like deep seismic sources allowing imaging of events above the borehole. It is also possible to redatum the receivers to the surface, making each shot into a receiver. This transforms the VSP data set into surface seismic data. I present some practical aspects of the method using synthetic examples to create a more intuitive understanding of the method.
Computationally Efficient Approaches to Simulate the Dynamics of Microbeams Under Mechanical Shock (2006)

We present computationally efficient models and approaches and utilize them to investigate the dynamics of microbeams under mechanical shock. We explore using a hybrid approach utilizing a beam model combined with the shock spectrum of a spring-mass-damper model. We conclude that this approach is computationally efficient and yields accurate results in both quasi-static and dynamic loading conditions. We utilize a reduced-order model based on the nonlinear Euler-Bernoulli beam model. We demonstrate that this model is capable of capturing accurately the dynamic behavior of microbeams under shock pulses of various amplitudes (low-g and high-g), in various damping conditions, structural boundaries (clamped-clamped and clamped-free), and can capture both linear and nonlinear behavior. We investigate high-g loading cases. We report significant increase in the computational cost of simulations when using traditional nonlinear finite-element models because of the activation of higher-order modes. We demonstrate that the developed reduced-order model can be very efficient in such cases.
Fayned News (2018)

When my students ask me, “What will be the next big thing in historical studies?,” I tell them to watch out for the history of public relations. The University of Bournemouth in the UK has a fairly new center devoted to the subject, Baruch College in Manhattan has just set up a Museum of Public Relations, and I think that’s just the beginning. Yes, plenty of work has been done on the history of advertising and propaganda, but PR is different: Dan Draper and Joseph Goebbels were perfectly upfront about what they were doing, but PR is a medium that commonly and deliberately disguises its own authorship. Let me state at the outset that everyone today uses publicists, and much of their work is entirely ethical. For publishers, they write up promotional material, send out review copies, arrange author interviews, and extract blurbs from reviews of their books—this one, for instance. But the main focus of this chapter is the kind of PR that surreptitiously plants stories in various media. It works only insofar as readers don’t recognize it, and therefore distrust of the media is in large measure a function of reader recognition of PR. The standard narrative holds that public relations was invented by Ivy Lee and Edward Bernays in the early twentieth century, but the basic concept of publicity can be traced back as far as Socrates’s Phaedrus, who observed that “an orator does not need to know what is really just, but what would seem just to the multitude who are to pass judgment, and not what is really good or noble, but what will seem to be so; for they say that persuasion comes from what seems to be true, not from the truth” (260a). One of the most brilliant PR agents of the pre-newspaper era was working before Shakespeare staged his first play.
Selective photocatalytic oxidation of benzene for the synthesis of phenol using engineered Au–Pd alloy nanoparticles supported on titanium dioxide (2014)

The selectivity of photocatalytic phenol production from the direct oxidation of benzene can be enhanced by fine adjustment of the morphology and composition of Au-Pd metal nanoparticles supported on titanium dioxide thereby suppressing the decomposition of benzene and evolution of phenolic compounds.