gebhart/patrepeval huggingface dataset:
Development of High-efficient Compact Organic Rankine Cycle Power Generation Technology utilizing Waste Heat (2017)

As the effective utilization method of unused heat energy between 100 and 300 degree-C in the industrial field, Organic Rankine Cycle(ORC) was selected from the viewpoint of high efficiency. The prototype of air-cooled compact ORC power generation system for 1kWe class was evaluated in comparison of the two working fluids, HFO-1336mzz(Z) and HFC-365mfc. The GWP of HFO-1336mzz(Z) is about 99.7% lower than that of HFC-365mfc. In the experimental results using HFO-1336mzz(Z), the generated power by the expander is 1,000W and the gross power generation efficiency is 10.5%. The gross power generation efficiency using HFO-1336mzz(Z) is equivalent to that using HFC-365mfc.
Impact of steroids on the inflammatory response after ischemic acute kidney injury in rats (2017)

Inflammation plays a crucial role in acute kidney injury (AKI). The current study was designed to analyze the influence of prednisolone treatment on the inflammatory reaction during the first 96 h after AKI induction in a rat model. AKI was induced by unilateral clipping of the renal vessels. The treatment group received prednisolone 5 mg/kg s.c. daily. Infiltration rates of macrophages, leukocytes, and T-cells (24, 96 h) as well as plasma concentrations of the inflammatory markers intercellular adhesion molecule, interleukin-1 beta (IL-1β), IL-18, IL-6, and tumor necrosis factor-alpha (0, 6, 24, 96 h) were determined by fluorescence-activated cell sorting (FACS) analysis only. Ninety-six hours after AKI induction, the prednisolone group demonstrated significantly lower creatinine concentrations compared to the control group (<i>P</i> < 0.05). Twenty-four hours after induction of AKI, a significantly higher rate of infiltrating leukocytes was detectable with FACS analysis in the control group (<i>P</i> < 0.01) with a corresponding significantly higher rate of macrophages after 96 h (<i>P</i> < 0.01). IL-6 and IL-1β demonstrated a peak after 6 h with a significantly higher release in the control group (IL-6: <i>P</i> < 0.01; IL-1β: <i>P</i> < 0.05). In contrast to the control group, the prednisolone group demonstrated no further incline of IL-18 after 24 h. The results demonstrate the importance of stretching the observation period in an ischemia-reperfusion-induced AKI setting beyond the first 24 h. Despite the demonstrated protective effects of a continuous prednisolone application, it seems that this single anti-inflammatory agent will not be able to completely suppress the inflammatory response after an ischemia-reperfusion-induced AKI.
Plasticity of the Nickel(II) Coordination Environment in Complexes with Hemilabile Phosphino Thioether Ligands (2011)

A series of homoligated Ni(II) complexes formed from two phosphino thioether (P,S) chelating ligands has been synthesized and characterized. Interestingly, this included octahedral Ni(II) complexes which, unlike previously characterized d(8) Rh(I), Pt(II), and Pd(II) analogues, exhibit in situ exchange processes centered around chloride ligand dissociation. This was verified and studied through the controlled abstraction from and introduction of chloride ions to this system, which showed that these processes proceed through complexes with square pyramidal, tetrahedral, and square planar geometries. These complexes were studied with a variety of characterization methods, including single-crystal X-ray diffraction studies, solution (31)P{(1)H} NMR spectroscopy, UV-vis spectroscopy, and DFT calculations. A general set of synthetic procedures that involve the use of coordinating and noncoordinating counteranions, as well as different hemilabile ligands, to mediate geometry transformations are presented.
The Low-Oxygen-Induced NAC Domain Transcription Factor ANAC102 Affects Viability of Arabidopsis Seeds following Low-Oxygen Treatment (2009)

Low-oxygen stress imposed by field waterlogging is a serious impediment to plant germination and growth. Plants respond to waterlogging with a complex set of physiological responses regulated at the transcriptional, cellular, and tissue levels. The Arabidopsis (Arabidopsis thaliana) NAC domain-containing gene ANAC102 was shown to be induced under 0.1% oxygen within 30 min in both roots and shoots as well as in 0.1% oxygen-treated germinating seeds. Overexpression of ANAC102 altered the expression of a number of genes, including many previously identified as being low-oxygen responsive. Decreasing ANAC102 expression had no effect on global gene transcription in plants but did alter expression patterns in low-oxygen-stressed seeds. Increasing or decreasing the expression of ANAC102 did not affect adult plant survival of low-oxygen stress. Decreased ANAC102 expression significantly decreased germination efficiency following a 0.1% oxygen treatment, but increased expression had no effect on germination. This protective role during germination appeared to be specific to low-oxygen stress, implicating ANAC102 as an important regulator of seed germination under flooding.
Consolidation and solidification behavior of thermoplastic composites (1996)

These Ecole polytechnique federale de Lausanne EPFL, n° 1474 (1996) Reference doi:10.5075/epfl-thesis-1474Print copy in library catalog Record created on 2005-03-16, modified on 2016-08-08
Extremely low back facet feedback by quantum-confined Stark effect absorption in an edge-emitting light-emitting diode (1993)

The quantum-confined Stark effect is employed to form an integral reverse-biased absorber in a GaInAsP edge-emitting light-emitting diode. Optical low coherence reflectometry is used to measure the magnitude of reflections through this absorber. Front-facet-back-facet roundtrip reflection magnitudes are below -110 dB in devices having an antireflection coating on the front facet only. All other round trip reflections are below -80 dB. This device provides a wide usable dynamic range in optical low coherence reflectometry measurements.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Distinct Thalamic Reticular Cell Types Differentially Modulate Normal and Pathological Cortical Rhythms (2017)

Integrative brain functions depend on widely distributed, rhythmically coordinated computations. Through its long-ranging connections with cortex and most senses, the thalamus orchestrates the flow of cognitive and sensory information. Essential in this process, the nucleus reticularis thalami (nRT) gates different information streams through its extensive inhibition onto other thalamic nuclei, however, we lack an understanding of how different inhibitory neuron subpopulations in nRT function as gatekeepers. We dissociated the connectivity, physiology, and circuit functions of neurons within rodent nRT, based on parvalbumin (PV) and somatostatin (SOM) expression, and validated the existence of such populations in human nRT. We found that PV, but not SOM, cells are rhythmogenic, and that PV and SOM neurons are connected to and modulate distinct thalamocortical circuits. Notably, PV, but not SOM, neurons modulate somatosensory behavior and disrupt seizures. These results provide a conceptual framework for how nRT may gate incoming information to modulate brain-wide rhythms.
Large-scale ATP-requiring enzymic phosphorylation of creatine can be driven by enzymic ATP regeneration (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLarge-scale ATP-requiring enzymic phosphorylation of creatine can be driven by enzymic ATP regenerationYen-Shiang Shih and George M. WhitesidesCite this: J. Org. Chem. 1977, 42, 25, 4165–4166Publication Date (Print):December 1, 1977Publication History Published online1 May 2002Published inissue 1 December 1977https://pubs.acs.org/doi/10.1021/jo00445a046https://doi.org/10.1021/jo00445a046research-articleACS PublicationsRequest reuse permissionsArticle Views328Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Real time and label-free analysis of cellular activity on chip (2009)

Biochips for cellular applications are of considerable interest to both fundamental research and diagnostic fields. In this study, we demonstrate the use of Surface Plasmon Resonance imaging (SPRi) for the analysis of blood cell activity on biochip. This method previously used to detect antigen-antibody interactions was adapted for the detection of antibodies secreted from B-cell hybridoma using specific antigens grafted on the chip by electropolymerization. For the first time, living cells were maintained in culture on the biochip and the kinetic of their secretion was monitored by SPRi. Unlike traditional methods such as ELISA or ELISPOT, this novel technique permits a real-time and label-free analysis. As a result, antibodies secreted were detected only few minutes after the loading of cells on the chip. Thus, this sensor provides a promising tool for cells phenotype analysis and could be useful in analyzing other secreting cells, like T-cells, widely involved in the inflammatory response and several pathologies.
Novel bis(benzamidino) compounds with an aromatic central link. Inhibitors of thrombin, pancreatic kallikrein, trypsin, and complement (1976)

A series of novel aromatic diamidines was synthesized and evaluated for antiproteolytic activity. The compounds were distignuished by inclusion of an aromatic ring structure--either benzene or bisbenzene or naphthalene--in the link between two amidinobenzene moieties. A highly potent inhibitor of bovine thrombin was discovered in alph, alph'-bis(4-amidino-2-iodophenoxy)-p-xylene with a Ki value of 1.1 X 10(-7) M (pH 8.1, 37 degrees), while alpha, alpha'-bis(4-amidino-2-iodophenoxy)-m-xylene was found to be an outstanding inhibitor of porcine pancreatic kallikrein (Ki = 3.1 X 10(-8) M). Several of the compounds investigated also demonstrated a considerable blocking effect on typsin and on the complement-dependent immune lysis of red cells.
Ovarian reserve in patients with spondyloarthritis: impact of biological disease-modifying anti-rheumatic drugs on fertility status (2021)

Our results support the use of bDMARDs in female patients with SpA. AMH levels were not influenced by bDMARDs nor by disease activity. AMH could be useful to assess the quantitative aspect of ovarian reserve in female SpA patients.
Deep neural networks for non-linear model-based ultrasound\n reconstruction (2018)

Ultrasound reflection tomography is widely used to image large complex\nspecimens that are only accessible from a single side, such as well systems and\nnuclear power plant containment walls. Typical methods for inverting the\nmeasurement rely on delay-and-sum algorithms that rapidly produce\nreconstructions but with significant artifacts. Recently, model-based\nreconstruction approaches using a linear forward model have been shown to\nsignificantly improve image quality compared to the conventional approach.\nHowever, even these techniques result in artifacts for complex objects because\nof the inherent non-linearity of the ultrasound forward model.\n In this paper, we propose a non-iterative model-based reconstruction method\nfor inverting measurements that are based on non-linear forward models for\nultrasound imaging. Our approach involves obtaining an approximate estimate of\nthe reconstruction using a simple linear back-projection and training a deep\nneural network to refine this to the actual reconstruction. We apply our method\nto simulated ultrasound data and demonstrate dramatic improvements in image\nquality compared to the delay-and-sum approach and the linear model-based\nreconstruction approach.\n
Structure of the functional part of photoprotein aequorin (1986)

The structure of the functional part of photoprotein aequorin is discussed based on the 13C n.m.r. spectra of aequorins prepared by incubation of specifically 13C-enriched coelenterazines into apoaequorin in the presence of 16O2 and 18O2, respectively.
Contrasting Roles of Islet Resident Immunoregulatory Macrophages and Dendritic Cells in Experimental Autoimmune Type 1 Diabetes (2016)

The innate immune system critically shapes diabetogenic adaptive immunity during type 1 diabetes (T1D) pathogenesis. While the role of tissue-infiltrating monocyte-derived macrophages in T1D is well established, the role of their tissue-resident counterparts remains undefined. We now demonstrate that islet resident macrophages (IRMs) from non-autoimmune mice have an immunoregulatory phenotype and powerfully induce FoxP3+ Tregs in vitro. The immunoregulatory phenotype and function of IRMs is compromised by TLR4 activation in vitro. Moreover, as T1D approaches in NOD mice, the immunoregulatory phenotype of IRMs is diminished as is their relative abundance compared to immunostimulatory DCs. Our findings suggest that maintenance of IRM abundance and their immunoregulatory phenotype may constitute a novel therapeutic strategy to prevent and/or cure T1D.
Quantum Services Architecture in Softwarized Infrastructures (2019)

Quantum computing is posing new threats on our security infrastructure. This has triggered a new research field on quantum-safe methods, and those that rely on the application of quantum principles are commonly referred as quantum cryptography. The most mature development in the field of quantum cryptography is called Quantum Key Distribution (QKD). QKD is a key exchange primitive that can replace existing mechanisms that can become obsolete in the near future. Although QKD has reached a high level of maturity, there is still a long path for a mass market implementation. QKD shall overcome issues such as miniaturization, network integration and the reduction of production costs to make the technology affordable. In this direction, we foresee that QKD systems will evolve following the same path as other networking technologies, where systems will run on specific network cards, integrable in commodity chassis. This work describes part of our activity in the EU H2020 project CiViQ in which quantum technologies, as QKD systems or quantum random number generators (QRNG), will become a single network element that we define as Quantum Switch. This allows for quantum resources (keys or random numbers) to be provided as a service, while the different components are integrated to cooperate for providing the most random and secure bit streams. Furthermore, with the purpose of making our proposal closer to current networking technology, this work also proposes an abstraction logic for making our Quantum Switch suitable to become part of software-defined networking (SDN) architectures. The model fits in the architecture of the SDN quantum node architecture, that is being under standardization by the European Telecommunications Standards Institute. It permits to operate an entire quantum network using a logically centralized SDN controller, and quantum switches to generate and to forward key material and random numbers across the entire network. This scheme, demonstrated for the first time at the Madrid Quantum Network, will allow for a faster and seamless integration of quantum technologies in the telecommunications infrastructure.
Antibiotics from basidiomycetes. XXXVIII. 2-Methoxy-5-methyl-1,4-benzoquinone, a thromboxane A2 receptor antagonist from Lentinus adhaerens. (1991)

In the course of our screening for antithrombotic compounds using platelet rich plasma from bovine slaughter blood, 2-methoxy-5-methyl-1,4-benzoquinone (1) has been isolated from mycelial cultures of Lentinus adhaerens. The compound inhibits the U46619-induced aggregation of human blood platelets with an IC50 of 2.5 micrograms/ml (16.45 microM) and is a new thromboxane A2 receptor antagonist. This is the first report on an inhibitor of platelet aggregation derived from secondary metabolism of basidiomycetes.
Plasmalemmal vacuolar H+‐ATPase is decreased in microvascular endothelial cells from a diabetic model (2004)

Angiogenesis requires invasion of extracellular matrix (ECM) proteins by endothelial cells and occurs in hypoxic and acidic environments that are not conducive for cell growth and survival. We hypothesize that angiogenic cells must exhibit a unique system to regulate their cytosolic pH in order to cope with these harsh conditions. The plasmalemmal vacuolar type H(+)-ATPase (pmV-ATPase) is used by cells exhibiting an invasive phenotype. Because angiogenesis is impaired in diabetes, we hypothesized that pmV-ATPase is decreased in microvascular endothelial cells from diabetic rats. The in vitro angiogenesis assays demonstrated that endothelial cells were unable to form capillary-like structures in diabetes. The proton fluxes were slower in cells from diabetic than normal model, regardless of the presence or absence of Na(+) and HCO(3) (-) and were suppressed by V-H(+)-ATPase inhibitors. Immunocytochemical data revealed that pmV-ATPases were inconspicuous at the plasma membrane of cells from diabetic whereas in normal cells were prominent. The pmV-ATPase activity was lower in cells from diabetic than normal models. Inhibition of V-H(+)-ATPase suppresses invasion/migration of normal cells, but have minor effects in cells from diabetic models. These novel observations suggest that the angiogenic abnormalities in diabetes involve a decrease in pmV-ATPase in microvascular endothelial cells.
A yeast artificial chromosome containing the mouse homeobox cluster Hox-2. (1990)

We have isolated two genes, Hox-2.8 and Hox-2.9, from the mouse homeobox cluster Hox-2, located on chromosome 11. A 120-kilobase yeast artificial chromosome (YAC) containing a large region of the murine Hox-2 cluster, including 45 kilobases of sequence upstream of the most 5' gene, was cloned. The DNA sequence of the YAC is unrearranged relative to the genomic map. We have subcloned from the YAC insert a homeobox gene, Hox-2.8, whose homeodolmain is highly related to that of the Drosophila homeotic gene proboscopedia (pb). The expression pattern of Hox-2.8 during embryogenesis extends the trend established by genes from Hox-2.5 to -2.7 of successively anterior domains of expression in the neural tube. We have also subcloned and sequenced from a cosmid the labial (lab)-related Hox-2.9, the most 3' member of the cluster to date. These data lend further support to the idea of a common evolutionary origin of the mouse Hox and Drosophila HOM clusters. The YAC will enable us to construct modified forms of the Hox-2 cluster in yeast and to identify their effect on the phenotype of the animal in transgenic mouse strains.
Using orientation Zernike polynomials to predict the imaging performance of optical systems with birefringent and partly polarizing components (2010)

Orientation Zernike Polynomials have been shown to provide a complete and systematic description of polarized imaging using the polar decomposition of the Jones pupil. We use this concept to predict the polarization performance of high NA lithography lenses.
Optically Pure Tricarbonyl(2-Methoxycinnamaldehyde)Chromium(0) and its Application to the Synthesis of Homochiral β-Lactams. (1994)

Optically pure tricarbonyl (2-methoxycinnamaldehyde) chromium(0) was prepared and the corresponding p-anisylimine used in a highly enantioselective synthesis of beta-lactams
Tailoring Mixed-Halide, Wide-Gap Perovskites via Multistep Conversion Process (2016)

Wide-band-gap mixed-halide CH3NH3PbI3-XBrX-based solar cells have been prepared by means of a sequential spin-coating process. The spin-rate for PbI2 as well as its repetitive deposition are important in determining the cross-sectional shape and surface morphology of perovskite, and, consequently, J-V performance. A perovskite solar cell converted from PbI2 with a dense bottom layer and porous top layer achieved higher device performance than those of analogue cells with a dense PbI2 top layer. This work demonstrates a facile way to control PbI2 film configuration and morphology simply by modification of spin-coating parameters without any additional chemical or thermal post-treatment.
New Affordable Methods for Large-Scale Isolation of Major Olive Secoiridoids and Systematic Comparative Study of Their Antiproliferative/Cytotoxic Effect on Multiple Cancer Cell Lines of Different Cancer Origins (2022)

Olive oil phenols (OOPs) are associated with the prevention of many human cancers. Some of these have been shown to inhibit cell proliferation and induce apoptosis. However, no systematic comparative study exists for all the investigated compounds under the same conditions, due to difficulties in their isolation or synthesis. Herein are presented innovative methods for large-scale selective extraction of six major secoiridoids from olive oil or leaves enabling their detailed investigation. The cytotoxic/antiproliferative bioactivity of these six compounds was evaluated on sixteen human cancer cell lines originating from eight different tissues. Cell viability with half-maximal effective concentrations (EC50) was evaluated after 72 h treatments. Antiproliferative and pro-apoptotic effects were also assessed for the most bioactive compounds (EC50 ≤ 50 μM). Oleocanthal (1) showed the strongest antiproliferative/cytotoxic activity in most cancer cell lines (EC50: 9−20 μM). The relative effectiveness of the six OOPs was: oleocanthal (1) > oleuropein aglycone (3a,b) > ligstroside aglycone (4a,b) > oleacein (2) > oleomissional (6a,b,c) > oleocanthalic acid (7). This is the first detailed study comparing the bioactivity of six OOPs in such a wide array of cancer cell lines, providing a reference for their relative antiproliferative/cytotoxic effect in the investigated cancers.
Verlauf und Einflussfaktoren von Tumor-assoziierter Fatigue bei Hodgkin-Lymphom: eine longitudinale Studie der deutschen Hodgkin-Studiengruppe (2018)

Aktuelle Kombinationstherapien des Hodgkin-Lymphoms (HL) erreichen hohe Heilungsraten und viele Patienten mit HL sind jünger als 40 Jahre. Persistierende tumorassoziierte Fatigue führt in diesem jungen Kollektiv neben der hohen individuellen Belastung oft zu einer dauerhaften Beeinträchtigung des Berufslebens. Wir beschreiben hier Fatigue-Daten, die aus drei großen randomisierten Studien der GHSG stammen und sich über den Zeitraum von der Diagnose bis fünf Jahre nach Therapie erstrecken.