gebhart/patrepeval huggingface dataset:
Effect of Vitamin E-Coated Dialysis Membranes on Anemia in Patients with Chronic Kidney Disease: An Italian Multicenter Study (2008)

Dialysis with VECM in stable chronic HD patients was associated with significantly improved Hb levels and lower rHuEpo requirements. These results suggest that the antioxidant properties of VECMs may impact favorably on anemia management in chronic HD patients. Possible mechanisms include enhanced membrane biocompatibility, reduced oxidative stress and inflammation with VECMs, resulting in improved red blood cell survival and/or rHuEpo responsiveness. This therapy may potentially contribute to more effective anemia management in hemodialysis patients, and merits further rigorous study.
Supplementary Figure 6 from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer <i>In Vivo</i> (2023)

&lt;p&gt;PDF file - 19K, Decrease response to CAF-derived clcf1 in cntfr-depleted tumor cells&lt;/p&gt;
Trends in silicon germanium BiCMOS integration and reliability (2002)

A base-after-gate integration scheme has been developed fora 0.25 /spl mu/m SiGe BiCMOS and the details of the approach are discussed. NPN device reliability is reviewed for high-frequency transistors. The reliability aspects associated with using SiGe for applications with high collector-base voltage with high emitter current are also explored. Finally, the ESD characteristics of the SiGe BiCMOS technology elements are summarized.
Regression of established subcutaneous B16‐F10 murine melanoma tumors after gef gene therapy associated with the mitochondrial apoptotic pathway (2009)

Novel treatment modalities, including gene therapy, are needed for patients with advanced melanoma. We evaluated whether the gef gene, a suicide gene from Escherichia coli, had a significant cytotoxic impact on melanoma in vivo. First, we used a non-viral gene delivery approach (pcDNA3.1/gef) to study the inhibition of melanoma cells (B16-F10) proliferation in vitro. Secondly, we used direct intra-tumoral injection of pcDNA3.1/gef complexed with jetPEI to deliver gef cDNA to rapidly growing murine melanomas. We demonstrated that gef gene not only has an antiproliferative effect on B16-F10 cells in vitro, but also induces an important decrease in melanoma tumor volume (77.7% in 8 days) in vivo. Interestingly, after gef gene treatment, melanoma showed apoptosis activation associated with the mitochondrial pathway, suggesting that the induction of this death mechanism may be an effective strategy for its treatment. Our in vivo results indicate that gef gene might become a suitable therapeutic strategy for patients with advanced melanoma.
Phase contrast neutron imaging of mixed phase-amplitude objects (2007)

A neutron imaging facility has been set up at the North Carolina State University (NCSU) PULSTAR reactor. Currently, work has started on tailoring the design of the facility to allow the performance of phase contrast neutron radiography. This is an imaging modality that has been extensively applied in X-ray imaging and was demonstrated using neutrons over the past few years. In this case, contrast formation in the image, especially at edges, is enhanced due to phase shifts that take place as the neutron wave passes through regions in the sample that differ in the coherent scattering length density. Usually, the pure phase object approximation is used to formulate the problem, whereas realistic samples represent mixed phase-amplitude objects. In this work, a formulation for mixed phase- amplitude objects with moderate neutron attenuation coefficients and its effect on the neutron image is being presented. Using computational simulations, it is observed that the pure phase object approximation results in over enhancement of edges for a phase-amplitude object, with significant change in the case of neutron imaging depending upon the edge forming material characteristics. The total contrast for the mixed phase-amplitude object is less than the sum of the individual attenuation and phase contrast components. The difference depends on the scalar product of the gradient of the coherent scattering length density and the attenuation coefficient. The presented formulation can aid in predicting the performance characteristics of neutron phase imaging experiments.
Robotized Stacking of the Uppsala University Wave Energy Converter Generator Stator (2014)

A technology for renewable energy conversion from ocean waves has been developed at Uppsala University. The concept is intended for large Wave Energy Converter farms and thus requires large series production lines. For this technology to be competitive on the global energy market, it is necessary to keep down the manufacturing costs. Assembly automation will therefore be important, especially if the production should be kept in industrialized countries. Stacking of the stator for the Wave Energy Converter generator is an essential task during the assembly process. The operation is repetitive and time-consuming, requires high precision and large reach and can thus be suitable for industrial robot automation. This paper presents a robot cell design for robotized automation of the stator stacking for an Uppsala University Wave Energy Converter generator. Prototype equipment has been developed and validated in an experimental stacking setup. From these experiments, it has been indicated that the proposed automation solution can substantially reduce the stacking cycle time while assuring sufficient assembly accuracy. The main advantages with the proposed assembly method are the high flexibility, the ability to lift and assemble multiple stator sheets at the same time, the ability to calibrate to the exact position of the stator sheet to be lifted and the high stacking accuracy result. The suggested robot cell is likely to be possible to adjust for stacking of other stator designs as well.
Location of a faulty module in a computing system (1990)

Considering the interplay between different phases of fault tolerance, a new problem of locating a faulty module in a computing system is formulated and solved. First, the probability of each module being faulty, or faulty probability, is calculated using the likelihood principle from the model parameters for fault detection, diagnostics, error propagation, and error detection. Then, based on the faulty probabilities and a given required diagnostic coverage, the order in which modules are to be diagnosed and the maximum time allotted to diagnose each module are determined by minimizing the average total diagnostic time. An example is presented and analyzed to answer the question of whether or not a system should delay the diagnosis upon detection of an error until more errors are detected.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Online subspace learning and nonlinear classification of Big Data with misses (2015)

`Big Data' classification is hindered by the large volume of often high-dimensional data, missing or absent features and, in streaming operation, the need for real-time processing. This paper aims at learning a kernelized support-vector-machine (SVM) classifier from (generally nonlinearly separable) large-scale incomplete data `on the fly.' Leveraging the low-rank attribute of the (even incomplete) data matrix, a novel online algorithm is developed for tracking the latent linear subspace jointly with the nonlinear classifier. Tailored for big data applications, dimensionality reduction based on the learned subspace is carried out online, while at the same time seeking the classifier in the reduced dimension. Performance analysis along with preliminary tests corroborate the effectiveness of the novel approach.
Distributed Feedback Laser Biosensor Incorporating a Titanium Dioxide Nanorod Surface (2010)

A 6.6× enhancement in surface sensitivity of DFB laser biosensors is demonstrated by a device incorporating a porous titanium dioxide nanorod layer on the sensor surface, while a Q-factor of over 25, 000 is maintained.
Cellular and molecular characterization of Ca2+ currents in acutely isolated, adult rat neostriatal neurons (1994)

Ca2+ currents in acutely isolated, adult rat neostriatal neurons were studied with whole-cell voltage-clamp techniques. In the vast majority of neurons (approximately 90%, n > 250), currents were exclusively of the high-voltage-activated (HVA) type. HVA currents activated near -40 mV and reached their maximum amplitude near 0 mV. Quasi-steady-state inactivation curves in many neurons were well fitted only with a sum of Boltzmann functions, suggesting that the HVA currents were heterogeneous. Although the block of whole-cell current by Cd2+ was well fitted with a single isotherm having an IC50 of near 1 microM, experiments with organic channel antagonists suggested that at least four types of HVA channels were expressed by most cells. On average, the L-channel antagonist nifedipine (5-10 microM) blocked 31 +/- 10% of the whole-cell current (n = 20), the N-channel antagonist omega-conotoxin GVIA (omega-CgTx) (2-5 microM) blocked 27 +/- 11% (n = 20), and the P-channel antagonist omega-agatoxin IVA (100-500 nM) blocked 21 +/- 10% (n = 18). In many neurons, the block by omega-CgTx was partially or completely reversible. In cells tested with a combination of these antagonists, 34 +/- 17% of the peak Ca2+ current remained unblocked (n = 13). Single-cell expression profiling of medium-sized neurons revealed the presence of rbA and rbB Ca2+ channel alpha 1 subunit mRNAs but low or undetectable levels of rbC mRNA (n = 12). These findings suggest that although adult neostriatal projection neurons do not express significant levels of LVA Ca2+ current, they do express a pharmacologically and structurally heterogeneous population of HVA currents.
Visual Place Recognition with Repetitive Structures (2015)

Repeated structures such as building facades, fences or road markings often represent a significant challenge for place recognition. Repeated structures are notoriously hard for establishing correspondences using multi-view geometry. They violate the feature independence assumed in the bag-of-visual-words representation which often leads to over-counting evidence and significant degradation of retrieval performance. In this work we show that repeated structures are not a nuisance but, when appropriately represented, they form an important distinguishing feature for many places. We describe a representation of repeated structures suitable for scalable retrieval and geometric verification. The retrieval is based on robust detection of repeated image structures and a suitable modification of weights in the bag-of-visual-word model. We also demonstrate that the explicit detection of repeated patterns is beneficial for robust visual word matching for geometric verification. Place recognition results are shown on datasets of street-level imagery from Pittsburgh and San Francisco demonstrating significant gains in recognition performance compared to the standard bag-of-visual-words baseline as well as the more recently proposed burstiness weighting and Fisher vector encoding.
Data from Integrated Next-Generation Sequencing and Avatar Mouse Models for Personalized Cancer Treatment (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Background:&lt;/b&gt; Current technology permits an unbiased massive analysis of somatic genetic alterations from tumor DNA as well as the generation of individualized mouse xenografts (Avatar models). This work aimed to evaluate our experience integrating these two strategies to personalize the treatment of patients with cancer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Methods:&lt;/b&gt; We performed whole-exome sequencing analysis of 25 patients with advanced solid tumors to identify putatively actionable tumor-specific genomic alterations. Avatar models were used as an &lt;i&gt;in vivo&lt;/i&gt; platform to test proposed treatment strategies.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Successful exome sequencing analyses have been obtained for 23 patients. Tumor-specific mutations and copy-number variations were identified. All samples profiled contained relevant genomic alterations. Tumor was implanted to create an Avatar model from 14 patients and 10 succeeded. Occasionally, actionable alterations such as mutations in &lt;i&gt;NF1&lt;/i&gt;, &lt;i&gt;PI3KA&lt;/i&gt;, and &lt;i&gt;DDR2&lt;/i&gt; failed to provide any benefit when a targeted drug was tested in the Avatar and, accordingly, treatment of the patients with these drugs was not effective. To date, 13 patients have received a personalized treatment and 6 achieved durable partial remissions. Prior testing of candidate treatments in Avatar models correlated with clinical response and helped to select empirical treatments in some patients with no actionable mutations.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusion:&lt;/b&gt; The use of full genomic analysis for cancer care is encouraging but presents important challenges that will need to be solved for broad clinical application. Avatar models are a promising investigational platform for therapeutic decision making. While limitations still exist, this strategy should be further tested. &lt;i&gt;Clin Cancer Res; 20(9); 2476–84. ©2014 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Tumor oxygenation using with the recombinant human serum albumin incorporating synthetic heme (rHSA-FeP) and the hemoglobin-vesicle (HbV) in a rat LY80 tumor model (2004)

Proc Amer Assoc Cancer Res, Volume 45, 2004

4132 

Current investigations suggested that hypoxic cells within the tumor have the potential resistance against chemotherapy or radiotherapy. These observations suggest that tumor oxygenation may play the important role in cancer treatment. Recently, we have developed two different types of artificial oxygen carriers. One is an artificial hemoprotein (rHSA-FeP), recombinant human serum albumin (rHSA) incorporating synthetic hemes, the tetrakis (o-pivalamido) phenylporphinatoiron (II) derivative. The other is hemoglobin vesicle (HbV), which is the red blood cell substitute encapsulating purified concentrated Hb in a phospholipid vesicle. This research is intended as an investigation of tumor oxygenation using with these new artificial oxygen carriers. We made a rat tumor model in which ascites hepatoma LY80 was implanted to the right femoral. And we compared the efficacy of artificial oxygen carriers as shown above. The LY80 tumor cells (approximately 3000000 cells, 0.03 ml) were injected into the right thigh of a Donryu rat 1 week before experiment. At the experiment, rats were maintained by mechanical ventilation with 1% halocen and 99% oxygen. The systemic oxygen pressure level was kept at approximately 400 Torr, and there were no differences in the basal values of each measurement among the rHSA-FeP, HbV, and rHSA (control) administration groups. Each solution saturated by oxygen was injected at the rate of 2.5 ml/min/kg, via a catheter placed at the bifurcation of iliac arteries. Using with the phpsphorescence lighting system, the average partial oxygen pressure of LY80 tumor was estimated throughout and after administration every 30 seconds. The measurement was continued for 15 minutes. The oxygen pressure of the tumor before administration was obviously low (range 1.4-1.7 Torr). The administration of the rHSA-FeP solution significantly increased the oxygen pressure of the tumor up to 3.45± 1.17 Torr, which corresponds to a 2.5-fold increase compared to that of the baseline value (P = 0.014). The administration of the HbV solution also increased the oxygen pressure of the tumor up to 2.54±1.47 Torr, which corresponds to a 1.8-fold increase compared to that of the baseline value (P = 0.048). The administration of the rHSA solution did not change the oxygen pressure of the tumor. The result can be interpreted that the artificial oxygen carriers pierced the tumor vessels, where erythrocytes could not transported oxygen to the hypoxic cells within the tumor. We conclude that the rHSA-FeP and HbV were potent useful agents with regard to tumor oxygenation. Tumor oxygenation, which may have synergistic effect with other cytotoxic therapy, merits further investigation.
Intravesical instillation of human urine after oral administration of trospium, tolterodine and oxybutynin in a rat model of detrusor overactivity (2005)

This is the first report that the urine excreted after oral ingestion of trospium (20 mg, twice daily) has a significant inhibitory effect in a rat model of detrusor overactivity. This suggests that antimuscarinic agents have a local bladder effect during the bladder-storage phase in addition to the smooth muscle-mediated voiding phase.
Polymeric Optical Waveguides (1990)

The present work describes the characterization of internally developed epoxy ridge optical waveguides which exhibit low propagation loss (0.3 dB/cm at 1.3 &mu;m), high environmental stability (low sensitivity to moisture), have smooth walls (100 nm sidewall roughness), and high temperature stability (275&deg;C). The techniques used to fabricate these waveguides are compatible with the planar processes used in the manufacture of high performance electronic packages.
Benchmark networks for grid integration impact studies of large PV plants (2013)

The increased amount of Photovoltaic (PV) power installed into the power system every year places this renewable way of producing electricity on the third position in the renewable sources hierarchy after hydro and wind solutions. Having significant levels of renewable power penetration into the system led to stability concerns of the entire system affecting its reliability and availability. In consequence system operators such as the European Network of Transmission System Operators for Electricity (ENTSO-E) had an immediate response imposing strict operating regulations in order to keep the system stable and harmonize the operation of the renewable plants with the entire system. For this purpose valid grid benchmarks such as IEEE 12 bus system for High Voltage (HV) and Cigré benchmark cell model for Medium Voltage (MV) have to be developed, tested together and prove that in the future power system with large PV penetration levels on every level, the system continues to be reliable and redundant.
ChemInform Abstract: Synthesis and Structure—Activity Relationship Studies of Pyrazole‐Based Heterocycles as Antitumor Agents. (2010)

Abstract A variety of new 1,5‐diphenylpyrazole derivatives substituted by different triazole or triazole bioisosteres at position 3 is synthesized and evaluated for their anti‐estrogenic effects and their cytotoxic properties against estrogen‐dependent tumor cell lines.
Supplementary Figure 1 from Sensitive Detection of Minimal Residual Disease in Patients Treated for Early-Stage Breast Cancer (2023)

&lt;p&gt;Analysis of recurrently mutated genes. (A) Fraction of patients covered using the most frequent mutations in each cancer cohort. (B) Gene panel performance using TCGA breast cancer data.&lt;/p&gt;
The Effect of Implant Placement on Sacroiliac Joint Range of Motion (2015)

N/A.
An update on the etiology of abdominal aortic aneurysms: implications for future diagnostic testing (2015)

Abdominal aortic aneurysm (AAA) disease is multifactorial with both environmental and genetic risk factors. The current research in AAA revolves around genetic profiles and expression studies in both human and animal models. Variants in genes involved in extracellular matrix degradation, inflammation, the renin-angiotensin system, cell growth and proliferation and lipid metabolism have been associated with AAA using a variety of study designs. However, the results have been inconsistent and without a standard animal model for validation. Thus, despite the growing body of knowledge, the specific variants responsible for AAA development, progression and rupture have yet to be determined. This review explores some of the more significant genetic studies to provide an overview of past studies that have influenced the current understanding of AAA etiology. Expanding our understanding of disease pathogenesis will inform research into novel diagnostics and therapeutics and ultimately to improve outcomes for patients with AAA.
A Study on Occurrence and Prevention of Defects of Electron Bean Welding (Report No.1) (1974)

Six types of plain carbon steels were electron beam welded using a 150kV high vacuum type machine. In the preliminary testing, a set of welding parameters was selected which produced the largest amount of blow-holes and voids at 20 mm penetration. Using this condition, effects of beam oscillation (X, Y, circle) of various frequencies and double welding on defect-formation were investigated.It was found that 100 to 1000 Hz X(in line of welding) beam oscillation and double pass welding were effective to prevent above mentioned defects, and (C) × (O) showed the best coincidence with the tendency of defect-occurrence.These findings suggest that formation of CO gas during welding is the main cause of blow-holes and voids, however (Mn) contents showed the same degree of coincidence which suggest another mechanism of defect-formation as proposed by Arata et al. Conclusions are left to further studies.Spikes did not change appreciably among six materials, and this fact seems to support the theory proposed by Tong.From metallurgical investigations, the anthers propose to adopt qp=EI/vp (J/cm2, where E: accerelating voltage kV, I: beam current mA, v; welding speed cm/sec, p: depth of penetration cm) parameter for metallurgical as well as deformation and stress analysis.
Highly linearly polarized emission at telecom bands from single InAs/InP quantum dot-nanowires by geometry tailoring (2022)

International audience
Extracorporeal Techniques Based on Adsorption: Nomenclature, Hardware, and Circuit Design (2023)

Sorbents have been utilized in the past for intoxication and poisoning, but their spectrum of clinical application is now expanding. Hemoadsorption (HA) is still indicated for toxin and poison removal, but other molecules are considered appropriate targets for this blood purification modality. HA combined with hemodialysis (HA + HD) has been proposed for end-stage kidney disease patients to remove molecules that are not easily removed by classic HD or hemodiafiltration. More recently, a rationale for the use of sorbents in critical illness, sepsis, and acute kidney injury has emerged due to the proposed humoral theory behind these disorders. Pathogenetic circulating molecules in critical illness (damage- and pathogen-associated molecular patterns) cannot be sufficiently removed by classic continuous renal replacement therapies. New sorbent-based extracorporeal therapies have therefore been designed to remove these molecules, offering potential biological and clinical benefits. There is also the possibility of employing selective sorbents to target specific molecules or to perform nonspecific HA for a wide spectrum of molecules. Moreover, there is the possibility of separating plasma from blood and then applying adsorption to plasma or of combining HA with other extracorporeal therapies. Here, we describe a complete appraisal of current available techniques utilizing adsorption.