gebhart/patrepeval huggingface dataset:
Loss of 17p, mutation of the p53 gene, and overexpression of p53 protein in esophageal squamous cell carcinomas. (1993)

We analyzed mutations of the p53 gene by single-strand conformation polymorphism analysis of polymerase chain reaction products and direct sequencing through all coding exons and exon-intron junctions in 32 cases with esophageal squamous cell carcinoma. Mutations were detected in 15 of 32 (47%) tumor samples, in which G:C to T:A transversions were rather frequent (33%). Previously, we reported deletion of chromosome 17p where the p53 gene is located in 45% of Japanese esophageal squamous cell carcinoma, and here the relationship between mutation of the p53 gene and loss of 17p was analyzed. Mutations were observed in 12 of 16 patients with loss of 17p, whereas only 2 of 11 without loss were positive for mutations, suggesting that mutations of the p53 gene were closely associated with a 17p deletion. Furthermore, we immunohistochemically analyzed the expression of p53 protein in esophageal squamous cell carcinoma tumor tissues using a monoclonal antibody. Five of 6 tumors with missense mutations of the p53 gene were positively stained, while in tumors with nonsense mutations or without mutations of the p53 gene staining was very weak or negative. These results suggest a good correlation between mutations and abnormal expression of the p53 gene.
Octave Spanning Tunable Frequency Comb from a Microresonator (2011)

We report the generation of an octave-spanning optical frequency comb in a continuous wave laser pumped microresonator. The generated comb spectrum covers the wavelength range from 990 to 2170 nm without relying on additional external broadening. Continuous tunability of the generated frequency comb over more than an entire free spectral range is demonstrated. Moreover, the linewidth of individual optical comb components and its relation to the pump laser phase noise is studied. The ability to derive octave-spanning spectra from microresonator comb generators represents a key step towards f-2f self-referencing of microresonator-based optical frequency combs.
Dynamic QR Codes for Augmented Reality (2013)

This work proposes the use of Quick Response (QR) codes as a mechanism of simultaneous data transmission and also 2D-3D registration for marker-based augmented reality (AR) systems. The decisions regarding the chosen 2D barcode were based on an analysis of the relationship between data size and available transmission time. The developed case study showed to be successful both at the detection of QR codes under perspective distortion and at the transmission of 3D models over the codes for further rendering.
More Semantics More Robust (2016)

Automatic malware classifiers often perform badly on the detection of new malware, i.e., their robustness is poor. We study the machine-learning-based mobile malware classifiers and reveal one reason: the input features used by these classifiers can't capture general behavioural patterns of malware instances. We extract the best-performing syntax-based features like permissions and API calls, and some semantics-based features like happen-befores and unwanted behaviours, and train classifiers using popular supervised and semi-supervised learning methods. By comparing their classification performance on industrial datasets collected across several years, we demonstrate that using semantics-based features can dramatically improve robustness of malware classifiers.
P‐209: New Green Phosphorescent Host Materials (2008)

Abstract We report novel bipolar host materials for high efficiency green phosphorescent organic light emitting diode devices (PHOLEDs). Phenyl moieties were inserted in a 4,4′‐N,N′‐dicarbazolebipheyl (CBP) structure to reduce electron injection barrier and enhance electron mobility. The significant improvement of current and power efficiencies and reduction in turn‐on voltage in green light‐emitting PHOLEDs by this modification are observed. At a given constant luminance of 1000 cd/m 2 , current efficiency 53 cd/A, low driving voltage 6.5 V, and power efficiency 27 lm/W in 4,4′‐N,N′‐dicarbazoleterpheyl (CTP) host with Ir(ppy)3 dopant are reported. Results show better performance in green PHOLEDs with new host materials than CBP.
Flexible Sensors Based on Radiation-Induced Diffusion of Ag in Chalcogenide Glass (2014)

In this paper, previous work on chalcogenide-glass (ChG)-based radiation sensors is extended to include the effects of mechanical strain and temperature stress on sensors formed on a flexible polymer substrate. We demonstrate the feasibility of producing inexpensive flexible radiation sensors, which utilize radiation-induced migration of Ag <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> ions in germanium selenide ( Ge <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">20</sub> Se <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">80</sub> ) films to produce a decrease in resistance of several orders of magnitude between surface electrodes. This change in resistance can be related to total ionizing dose to give an instantaneous readout of radiation exposure. The ChG films are inherently flexible and this, along with an extremely simple device fabrication process at or near room temperature, allows inexpensive sensor structures to be fabricated on lightweight pliable polymeric substrates such as polyethylene napthalate (PEN). Test samples were irradiated with ionizing radiation (UV light and <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">60</sup> Cobalt gamma rays). Irradiated samples were subjected to both tensile and compressive stress, and elevated operating temperatures. Stress and exposure to increased ambient temperature had little effect on device resistance. Analysis of the experimental data is supported by the results of COMSOL simulations that model radiation-induced lateral Ag diffusion in ChG.
Prolonged evolution of the memory B cell response induced by a replicating adenovirus-influenza H5 vaccine (2019)

Induction of an antibody response capable of recognizing highly diverse strains is a major obstacle to the development of vaccines for viruses such as HIV and influenza. Here, we report the dynamics of B cell expansion and evolution at the single-cell level after vaccination with a replication-competent adenovirus type 4 recombinant virus expressing influenza H5 hemagglutinin. Fluorescent H1 or H5 probes were used to quantitate and isolate peripheral blood B cells and their antigen receptors. We observed increases in H5-specific antibody somatic hypermutation and potency for several months beyond the period of active viral replication that was not detectable at the serum level. Individual broad and potent antibodies could be isolated, including one stem-specific antibody that is part of a new multidonor class. These results demonstrate prolonged evolution of the B cell response for months after vaccination and should be considered in efforts to evaluate or boost vaccine-induced immunity.
Voltage Balancing Control Method Using Variable Capacitors with Simple Turn-on Adjusting Function for Multi-Stage FET Bidirectional Converter (2020)

This paper proposes a voltage balancing control method using variable capacitors with simple turn-on adjusting function for multi-stage FET bidirectional converter. The proposed voltage balancing control circuit is composed of a feedback circuit using photocouplers and a delay circuit using variable capacitors with turn-on adjusting diodes. The proposed voltage balancing circuit can reduce the drain-source voltage unbalance which occur during the turn-on and turn-off period of series-connected FETs. The theoretical discussion includes analyzing the unbalanced drain-source voltage in seriesconnected FETs using a simplified converter. Also, the principal of the proposed voltage balancing control method is clarified. The experimental results show that the proposed voltage balancing control method can reduce the drain-source voltage difference Δv <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ds</sub> of series-connected FETs from 36 V to 11 V (69% reduction in Δv <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ds</sub> ) during the turn-off and from 22 V to 11 V (50% reduction in Δv <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ds</sub> ) during the turn-on period. The multistage FET bidirectional converter can achieve a maximum power conversion efficiency of 99.2%.
Smaller Body Size Increases the Percentage of Blood Volume Lost During Posterior Spinal Arthrodesis (2015)

There is an inverse relationship between the proportion of blood volume lost during deformity correction surgery and size in patients with adolescent idiopathic scoliosis, cerebral palsy, or Scheuermann kyphosis.
Building direct and back spanning trees by automata on a graph (2014)

The paper presents a parallel graph exploration algorithm. Automaton on a graph is an analogue of the Turing machine тАФ tape cells correspond to graph vertices, where the automaton can store some data, and moves along the tape correspond to moves along graph arcs. This system can be considered also as an aggregate of finite automatons located in graph vertices and interacting by message sending. Each automaton changes its state according to the data stored in the corresponding vertex, and moves along graph arcs are replaced with messages sent by the automaton of the arcтАЩs starting vertex to the one of the ending vertex. The suggested parallel graph exploration algorithm has worst case working time bound O(n/k+D), where n is the number of vertices, and D is the graph diameter, the maximum length of simple path (non-self intersecting path). As a result the algorithm builds two spanning trees of the graph: the direct spanning tree, which has the root vertex as its tree root and is directed from the root, and the back spanning tree, directed to the root.
Subcortical amyloid load is associated with shape and volume in cognitively normal individuals (2019)

Amyloid-beta (Aβ) deposition is one of the main hallmarks of Alzheimer's disease. The study assessed the associations between cortical and subcortical <sup>11</sup> C-Pittsburgh Compound B (PiB) retention, namely, in the hippocampus, amygdala, putamen, caudate, pallidum, and thalamus, and subcortical morphology in cognitively normal individuals. We recruited 104 cognitive normal individuals who underwent extensive neuropsychological assessment, PiB-positron emission tomography (PET) scan, and 3-T magnetic resonance imaging (MRI) acquisition of T1-weighted images. Global, cortical, and subcortical regional PiB retention values were derived from each scan and subcortical morphology analyses were performed to investigate vertex-wise local surface and global volumes, including the hippocampal subfields volumes. We found that subcortical regional Aβ was associated with the surface of the hippocampus, thalamus, and pallidum, with changes being due to volume and shape. Hippocampal Aβ was marginally associated with volume of the whole hippocampus as well as with the CA1 subfield, subiculum, and molecular layer. Participants showing higher subcortical Aβ also showed worse cognitive performance and smaller hippocampal volumes. In contrast, global and cortical PiB uptake did not associate with any subcortical metrics. This study shows that subcortical Aβ is associated with subcortical surface morphology in cognitively normal individuals. This study highlights the importance of quantifying subcortical regional PiB retention values in these individuals.
AGS-16M18: A novel therapeutic human monoclonal antibody for the treatment of kidney and liver cancers (2008)

3050 Background: AGS-16 is a novel cell surface protein expressed in over 95% of kidney cancers, including clear cell and papillary carcinomas, and ∼40% of hepatocellular carcinomas. Amongst normal tissues, AGS-16 is expressed predominantly in kidney proximal tubules. In vitro validation studies using AGS-16 purified protein and AGS-16 expressing kidney and liver cancer cells have demonstrated AGS-16 involvement in tumor cell proliferation, migration and invasion, and induction of tube formation by human umbilical vein endothelial cells (HUVEC). Methods and Results: XenoMouse technology was employed to identify AGS-16M18, a fully human IgG1λ monoclonal antibody (MAb) with a Kd = 2.6 x 10-10M for cell surface AGS-16, which demonstrated potent activity in all of the in vitro assays. AGS-16M18 inhibited proliferation and survival of both RXF-393 and HepG2 tumor cell lines in a dose-dependent manner. In addition, AGS-16M18 dose-dependently inhibited AGS-16-induced HUVEC tube formation. AGS-16M18 inhibited HepG2 cell migration and invasion. Significant antitumor efficacy of AGS-16M18 in vivo was observed on well established patient-derived clear cell kidney cancer xenografts and hepatocellular carcinomas. Biomarker analysis of AGS-16M18- treated tumors revealed a significant impact of the antibody on proliferation (ERK, AKT) and apoptosis (PARP) pathways. Efficacy of AGS-16M18 was maintained after MAb de-glycosylation, indicating an intrinsic antitumor activity of the MAb without apparent contribution by immune effector functions. When AGS-16M18 was combined with targeted therapies such as bevacizumab, sunitinib malate, or rapamycin, synergistic antitumor efficacy was observed. Conclusions: These data validate AGS-16 as an attractive target for kidney and liver cancers, and establish AGS-16M18 as a potential therapeutic MAb for these cancer indications. Activities are underway to progress this promising AGS-16M18 into human clinical trials. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Agensys Agensys
How many neurons can we see with current spike sorting algorithms? (2012)

Recent studies highlighted the disagreement between the typical number of neurons observed with extracellular recordings and the ones to be expected based on anatomical and physiological considerations. This disagreement has been mainly attributed to the presence of sparsely firing neurons. However, it is also possible that this is due to limitations of the spike sorting algorithms used to process the data. To address this issue, we used realistic simulations of extracellular recordings and found a relatively poor spike sorting performance for simulations containing a large number of neurons. In fact, the number of correctly identified neurons for single-channel recordings showed an asymptotic behavior saturating at about 8-10 units, when up to 20 units were present in the data. This performance was significantly poorer for neurons with low firing rates, as these units were twice more likely to be missed than the ones with high firing rates in simulations containing many neurons. These results uncover one of the main reasons for the relatively low number of neurons found in extracellular recording and also stress the importance of further developments of spike sorting algorithms.
On Universal Variable-Rate Slepian-Wolf Coding (2008)

Lower and upper bounds on the reliability region of universal variable-rate Slepian-Wolf coding are derived.
Boron–Diindomethene (BDI) Dyes and Their Tetrahydrobicyclo Precursors—en Route to a New Class of Highly Emissive Fluorophores for the Red Spectral Range (2004)

The X-ray crystallographic, optical spectroscopic, and electrochemical properties of a newly synthesized class of boron-diindomethene (BDI) dyes and their tetrahydrobicyclo precursors (bc-BDP) are presented. The BDI chromophore was designed to show intensive absorption and strong fluorescence in an applicationary advantageous spectral range. Its modular architecture permits fusion of a second subunit, for example, a receptor moiety to the dye's core to yield directly linked yet perpendicularly prearranged composite systems. The synthesis was developed to allow facile tuning of the chromophore platform and to thus adjust its redox properties. X-ray analysis revealed a pronounced planarity of the chromophore in the case of the BDIs, which led to a remarkable close packing in the crystal of the simplest derivative. On the other hand, deviation from planarity was found for the diester-substituted bc-BDP benzocrown that exhibits a "butterfly"-like conformation in the crystal. Both families of dyes show charge- or electron-transfer-type fluorescence-quenching characteristics in polar solvents when equipped with a strong donor in the meso-position of the core. These processes can be utilized for signaling purposes if an appropriate receptor is introduced. Further modification of the chromophore can invoke such a guest-responsive intramolecular quenching process, also for receptor groups of low electron density, for example, benzocrowns. In addition to the design of various prototype molecules, a promising fluoroionophore for Na+ was obtained that absorbs and emits in the 650 nm region and shows a strong fluorescence enhancement upon analyte binding. Furthermore, investigation of the remarkable solvatokinetic fluorescence properties of the "butterfly"-like bc-BDP derivatives suggested that a second intrinsic nonradiative deactivation channel can play a role in the photophysics of boron-dipyrromethene dyes.
Outer Bounds for a Joint Communicating Radar (Comm-Radar): The Uplink Case (2021)

Limited access to available spectrum motivates new age radio frequency (RF) systems to co-exist and cooperate. In this paper, we consider a joint communication and radar system (labeled Comm-Radar), that is capable of receiving and decoding communication signals while simultaneously enabling radar functionalities. Traditionally, systems that leverage principles of spectrum convergence, deemed each functions to be detrimental to the others. This has led to successive interference cancellations strategies that effectively isolate each of the functionalities. Here, in the context of Comm-Radar processing structure, we show that ambient communication transmissions actually assist in radar estimation. The insight is that communications multipath reflects off radar targets (we denote these comm-target paths) in the environment, and can be processed at the receiver to extract extra information. In this work we characterize the fundamental performance limits of such a joint system.To demonstrate the radar performance gain achievable via the processing of extra comm-target paths, the closed-form Cramér-Rao Bound (CRB) for the estimation of direction, range and velocity of a target is derived, for both the general case, and practical radar and communication signalling schemes. Based on the CRB, joint outer bounds are obtained to characterize the trade off between estimation performance and communication rate. Finally, numerical results verify the advantages of utilizing the target reflections from the communication signal to bolster radar performance.
ChemInform Abstract: Reinvestigation of the Coupling Reaction of 2‐Aryl‐1,1‐dibromo‐3,3,3‐trifluoropropenes. Preparation of Perfluoroalkylated [3]Cumulenes. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
1996 IEEE INTERNATIONAL FREQUENCY CONTROL SYMPOSIUM REDUCING THE NORMAL ACCELERATION SENSITIVITY OF SURFACE TRANSVERSE WAVE RESONATORS USING MICROMACHINED ISOLATION SYSTEMS (1996)

AMSRL-PS-ED Abstract Micromachined silicon platforms provide two methods for reducing the acceleration sensitivity of surface transverse wave resonators. First, micromachining allows precise control over the structure of the silicon mounting platform and supports. The platform can thus be shaped to apply stresses to the resonator such that the minimum acceleration sensitivity is achieved. Second, a platform supported by flexible arms acts as a vibration isolation system, thus reducing the effective acceleration applied to the resonator. A study of a silicon micromachined isolation platform has been performed. Numerical analysis has been used to determine the effect of stress on the resonator, while a mass spring model has been used to predict the effective acceleration applied to the resonator.
Kinetic studies of ligand substitution reactions and general-base catalysis in amine-ligand exchange processes for Group 6B metal carbonyl amine derivatives. Kinetic and spectroscopic evidence for hydrogen-bonded intermediates (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetic studies of ligand substitution reactions and general-base catalysis in amine-ligand exchange processes for Group 6B metal carbonyl amine derivatives. Kinetic and spectroscopic evidence for hydrogen-bonded intermediatesDonald J. Darensbourg and John A. EwenCite this: Inorg. Chem. 1981, 20, 12, 4168–4177Publication Date (Print):December 1, 1981Publication History Published online1 May 2002Published inissue 1 December 1981https://pubs.acs.org/doi/10.1021/ic50226a029https://doi.org/10.1021/ic50226a029research-articleACS PublicationsRequest reuse permissionsArticle Views186Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Transcriptional profiling identifies strain-specific effects of caloric restriction and opposite responses in human and mouse white adipose tissue (2018)

Caloric restriction (CR) has been extensively studied in rodents as an intervention to improve lifespan and healthspan. However, effects of CR can be strain- and species-specific. This study used publically available microarray data to analyze expression responses to CR in males from 7 mouse strains (C57BL/6J, BALB/c, C3H, 129, CBA, DBA, B6C3F1) and 4 tissues (epididymal white adipose tissue (eWAT), muscle, heart, cortex). In each tissue, the largest number of strain-specific CR responses was identified with respect to the C57BL/6 strain. In heart and cortex, CR responses in C57BL/6 mice were negatively correlated with responses in other strains. Strain-specific CR responses involved genes associated with olfactory receptors (<i>Olfr1184</i>, <i>Olfr910</i>) and insulin/IGF-1 signaling (<i>Igf1</i>, <i>Irs2</i>). In each strain, CR responses in eWAT were negatively correlated with those in human subcutaneous WAT (scWAT). In human scWAT, CR increased expression of genes associated with stem cell maintenance and vascularization. However, orthologous genes linked to these processes were down-regulated in mouse. These results identify strain-specific CR responses limiting generalization across mouse strains. Differential CR responses in mouse versus human WAT may be due to differences in the depots examined and/or the presence of "thrifty genes" in humans that resist adipose breakdown despite caloric deficit.