gebhart/patrepeval huggingface dataset:
αEβ7integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis (2007)

Various T cell adhesion molecules and their cognate receptors on target cells promote T cell receptor (TCR)-mediated cell killing.In this report, we demonstrate that the interaction of epithelial cell marker E-cadherin with integrin E (CD103) 7 , often expressed by tumorinfi ltrating lymphocytes (TILs), plays a major role in effective tumor cell lysis.Indeed, we found that although tumor-specifi c CD103 + TIL-derived cytotoxic T lymphocyte (CTL) clones are able to kill E-cadherin + /intercellular adhesion molecule 1 -autologous tumor cells, CD103 -peripheral blood lymphocyte (PBL)-derived counterparts are ineffi cient.This cell killing is abrogated after treatment of the TIL clones with a blocking anti-CD103 monoclonal antibody or after targeting E-cadherin in the tumor using ribonucleic acid interference.Confocal microscopy analysis also demonstrated that E 7 is recruited at the immunological synapse and that its interaction with E-cadherin is required for cytolytic granule polarization and subsequent exocytosis.Moreover, we report that the CD103 - profi le, frequently observed in PBL-derived CTL clones and associated with poor cytotoxicity against the cognate tumor, is up-regulated upon TCR engagement and transforming growth factor 1 treatment, resulting in strong potentiation of antitumor lytic function.Thus, CD8 + /CD103 + tumor-reactive T lymphocytes infi ltrating epithelial tumors most likely play a major role in antitumor cytotoxic response through E 7 -E-cadherin interactions.
π-Conjugated Polyradicals With Poly(Phenylene-Vinylene) Skeleton and Their Through-Bond and Long-Range Interaction (1995)

Abstract The poly(phenylenevinylene) skeleton was selected as a magnetic coupler of polyradicals, because of its developed π-conjugation, coplanarity, and solvent-solubility even after substitution on the phenylene ring. By synthesizing poly(1,4- or 1,2-phenylenevinylene)-2- or -4-substituted with a stable phenoxy or nitroxy radical, an intramolecular, through-bond and long-range, but strong, ferromagnetic exchange interaction was realized for the first time. The polyradicals were chemically stable and, even at their spin concentration of ca. 0.5, displayed S values of 2/2 ∼ 4/2.
[Head and neck cancer patients' experiences with accelerated diagnostic and treatment programs]. (2010)

Repetition of information and programme continuity is important as these factors allow patients to "keep up" with the programme. Personal contact and communication between patient and staff is essential for a successful accelerated programme. Time of diagnosis, scheduling of a date for the initial treatment or the start-up of the initial treatment are crucial turning points during the programme - points at which patients started feeling more calm.
The Corrosion Resistance of Fe-Based Amorphous Metals: Fe<sub>49.7</sub>Cr<sub>17.7</sub>Mn<sub>1.9</sub>Mo<sub>7.4</sub>W<sub>1.6</sub>B<sub>15.2</sub>C<sub>3.8</sub>Si<sub>2.4</sub> and Other Compositions (2024)

Several Fe-based amorphous metals were developed with good corrosion resistance. These materials have been produced as melt-spun ribbons, ingots, and thermal-spray coatings. Cyclic polarization has been conducted in several aggressive environments, at ambient temperature, as well as temperatures approaching the boiling points of the test solutions. The hypothesis that the corrosion resistance of iron-based amorphous metals can be enhanced through application of heuristic principles related to the additions of chromium, molybdenum, tungsten has been tested and found to have merit. Chromium (Cr), molybdenum (Mo) and tungsten (W) provide corrosion resistance; boron (B) enables glass formation; and rare earths such as yttrium (Y) lower critical cooling rate (CCR). The high boron content of this particular amorphous metal makes this amorphous alloy an effective neutron absorber, and suitable for criticality control applications. In general, the corrosion resistance of such iron-based amorphous metals is maintained at operating temperatures up to the glass transition temperature.
Abstract 2776: Inhibition of Nek2 by novel small molecules affects proteasome activity (2012)

Abstract Nek2 is a serine/threonine kinase that has been associated with centrosome function and cell cycle progression. Nek2 overexpression has been reported in several tumor types including breast and lung cancers. We have previously shown that elevated expression of Nek2 in clinical samples of multiple myeloma (MM) correlates with bortezomib resistance. Furthermore, the overexpression of Nek2 in MM cell lines decreases sensitivity to bortezomib and knockdown with RNAi sensitizes bortezomib resistant cells. Due to the proteaseome inhibitory activity of bortezomib, we hypothesized that Nek2 overexpression may increase proteasome activity. 26S proteasomes were isolated by ultracentrifugation from stably transfected Hela cells (+Nek2 or +GFP) and Nek2 was shown to be involved in the 26S proteasome complex by western blot. Proteasome activity assays were performed both biochemically and in cell culture demonstrating that proteasome activity in Hela+Nek2 is significantly higher than in Hela+GFP. Furthermore, the isolated 26S proteasomes were incubated with novel Nek2 inhibitors (HCI-2184 and HCI-2389) resulting in a significant reduction in proteasome function when used as single agents or in combination with bortezomib. HCI-2184, a reversible inhibitor of Nek2, demonstrated an IC50 value in the range of 13-38 nM, and HCI-2389, an irreversible inhibitor of Nek2, showed an IC50 value between 8-26 nM. Similarly, both compounds significantly increased the efficacy of bortezomib in inhibiting the proteasome activity. These results were confirmed in multiple cancer cell lines, including ARP1 (human MM cell line), H299 (human lung cancer cell line) and K28 (mouse Leydig tumor cell line). The effect of inhibiting Nek2 on cell cycle was also investigated. The expression levels of cyclinB1 and cdc2, proteins degraded by the proteasome for cells to exit mitosis, were increased in HCI-2389 treated Hela+Nek2 and to a lesser extent Hela+GFP treated cells. While Nek2 overexpression leads to the down-regulation of cyclinB1 and cdc2, HCI-2389 treatment successfully rescued this effect. Flow cytometry data showed that both treatments of HCI-2184 and HCI-2389 significantly arrested Hela+Nek2 and Hela+GFP in G2/M phase after 24 hours at concentration as low as 10nM. In conclusion, we have discovered a novel biological function of Nek2 related to elevated proteasome activity. We also demonstrated that our novel Nek2 inhibitors efficiently inhibit Nek2 function, resulting in reduced proteasome activity. These Nek2 inhibitors have the potential to be applied clinically for treatment of the MM patients resistant to bortezomib. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2776. doi:1538-7445.AM2012-2776
Comparison of MRI and 18F‐NaF PET/CT in patients with patellofemoral pain (2012)

Our results suggest that (18) F-NaF PET/CT may provide additional information in patellofemoral pain patients compared to MRI.
Auditory cortex in the grey squirrel: Tonotopic organization and architectonic fields (1976)

The representation of sound frequency within auditory cortex has been investigated with microelectrode mapping techniques in grey squirrels. The cyto- and myeloarchitecture of mapped cortical surfaces was examined and related to recording data. Among the results were the following: (1) A primary field can be defined on the basis of both physiological and anatomical criteria.
Circular Coding for Data Embedding (2013)

A general two-dimensional coding means is presented that allows recovery of data with only a cropped portion of the code, and without knowledge of the carrier image. A description of both an encoding and recovery system is provided, along with an illustrative example. Our solution involves repeating a payload with a fixed number of bits assigning one bit to every symbol in the image, whether that symbol is data carrying or non-data carrying, with the goal of guaranteeing recovery of all the bits in the payload. The system uses row-to-row offset itself to communicate the value of the phase of the circular payload. The recovery system is given the number bits in the payload, evaluates each candidate shift and ranks its confidence based on the variance of the payload bits. Symbols determined to be unsuitable for recovery are labeled &#x201C;abstentions&#x201D; and not included in the decoding process; special consideration is given to the checkerboard subsampling that can occur in the case when halftone cells are used as the data-carrying symbols. This particular application is examined via tests to quantify the likelihood of unrecoverable bits and bit redundancy as a function of phase and crop window size.
High Efficiency Silver-Free Heterojunction Silicon Solar Cell (2012)

In this work, we present the results of the replacement of silver screen printing on heterojunction crystalline silicon (c-Si) solar cells with a copper metallization scheme that has the potential to reduce the manufacturing cost while improving their performance. We report for the first time silver-free heterojunction c-Si solar cells on 6-in. wafers. The conversion efficiency reached is a record 22.1% for c-Si technology for this wafer size ( V oc = 729 mV, J sc = 38.3 mA/cm 2 , FF= 79.1%). The total power generated is more than 5 W for 1-sun illumination, which is a world record. Heat-damp reliability tests show comparable performance for mini-modules fabricated with copper metalized as for conventional silver screen printed heterojunction c-Si solar cells.
Polymers for drug delivery (2015)

AccessScience is an authoritative and dynamic online resource that contains incisively written, high-quality educational material covering all major scientific disciplines. An acclaimed gateway to scientific knowledge, AccessScience is continually expanding the ways it can demonstrate and explain core, trustworthy scientific information that inspires and guides users to deeper knowledge.
Submillisecond-lived photoinduced charge separation in a fully conjugated phthalocyanine–perylenebenzimidazole dyad (2014)

A fully electronically conjugated phthalocyanine–perylenemonoimidebenzimidazole system has been synthesized, in which the conjugation goes through the imide position of the perylene.
Deformable triangular surfaces using fast 1-D radial Lagrangian dynamics-segmentation of 3-D MR and CT images of the wrist (2002)

We developed a new triangulated deformable surface model, which is used to detect the boundary of the bones in three-dimensional magnetic resonance (MR) and computed tomography (CT) images of the wrist. This surface model is robust to initialization and provides wide geometrical coverage and quantitative power. The surface is deformed by applying one-dimensional (1-D) radial Lagrangian dynamics. For initialization a tetrahedron is placed within the bone to be segmented. This initial surface is inflated to a binary approximation of the boundary. During inflation, the surface is refined by the addition of vertices. After the surface is fully inflated, a detailed, accurate boundary detection is obtained by the application of radial scale-space relaxation. In this optimization stage, the image intensity is filtered with a series of 1-D second-order Gaussian filters. The resolution of the triangulated mesh is adapted to the width of the Gaussian filter. To maintain the coherence between the vertices, a resampling technique is applied which is based on collapsing and splitting of edges. We regularized the triangulated mesh by a combination of volume-preserving vertex averaging and equi-angulation of edges. In this paper, we present both qualitative and quantitative results of the surface segmentations in eight MR and ten CT images.
Une brève histoire de la mycologie lyonnaise à travers ses figures linnéennes les plus emblématiques (2009)

La Société linnéenne de Lyon a depuis son origine joué un rôle essentiel dans le développement de la mycologie dans le Lyonnais — et même au-delà — grâce aux personnalités qui ont écrit les pages de son histoire. Cette note présente quelques-uns des acteurs les plus emblématiques de notre Société et trace les grandes lignes de cette histoire de la mycologie lyonnaise.
Development, Application and Future Trends of Pyrrolidone‐ and Caprolactam‐Based Materials in the Pharmaceutical Industry (2021)

Abstract The initial success of polyvinylpyrrolidone (PVP) as a blood plasma expander in Europe and later in the United States led to further clinical investigation into the polymer's biological interactions. Pharmaceutical excipients constitute the majority ingredients of a medicine. The excipients, apart from meeting the stringent quality and safety requirements for medical usage, play a crucial role in ensuring stability and bioavailability of the active principles. Solubility and solubilization are important concepts in the pharmaceutical industry. The chapter presents the discussions on delivery of drugs by nanoparticles and amorphous solid dispersions cover aspects of molecular complex formation between drugs and pyrrolidone‐ or lactam‐based materials. Formulations based on povidone iodine continue to remain popular even decades after their first uses for wound healing and antisepsis. Stronger binding in the lower dendrimers may have utility in certain drug delivery situations, where complex stability coupled to drug delivery to the destination are deemed critical to the treatment situation.
Linkage analysis of schizophrenia controlling for population substructure (2008)

Etiological heterogeneity and complexity has hampered attempts to identify predisposing genes for schizophrenia. We sought to minimize the number of segregating genes involved by focusing on a population isolate with elevated disease prevalence. We exploited the well-established population history, and searched for disease susceptibility loci in families from two alternative founder lineages. We studied 28 schizophrenia pedigrees (123 nuclear families) from an outlying municipality on the eastern border of Finland. We divided the families based on their genealogy and defined two routes of immigration: southern and northern. We examined the kinship coefficients and allele frequency distributions within each group, and performed a linkage analysis based on 497 microsatellite markers across the genome. A high degree of historical relatedness was demonstrated by higher sharing of alleles than predicted by the relationships we identified within the previous four generations alone, as would be expected. Between the two subpopulations, allele frequencies were significantly different, consistent with their isolated genealogies. The southern families showed some evidence of linkage in a schizophrenia locus at 4q23 (Z = 3.3) near our previous finding with quantitative variation in verbal learning and memory [Paunio et al. (2004); Hum Mol Genet 13: 1693-1702], while the northern pedigrees gave most significant evidence on 10q21 (Z = 2.53). Joint analysis of families from both lineages suggested evidence of linkage only at 3p14 (Z = 3.18). Thus the detailed genealogical information led us to identification of distinct linkage signals for schizophrenia susceptibility loci between the three analyses we performed.
ChemInform Abstract: Preparation of Hindered Styrenes and Arylacetylenes. (1989)

Abstract The substituted trimethoxyphenyl iodides (I) are coupled with the vinylsilane (II) or the ethynylsilane (IV) in the presence of a Pd(II) phosphine catalyst, yielding the silylstyrenes (III) and the arylsilylacetylenes (V) respectively.
Endothelial cells are intrinsically defective in xenophagy of Streptococcus pyogenes (2017)

Group A Streptococcus (GAS) is deleterious pathogenic bacteria whose interaction with blood vessels leads to life-threatening bacteremia. Although xenophagy, a special form of autophagy, eliminates invading GAS in epithelial cells, we found that GAS could survive and multiply in endothelial cells. Endothelial cells were competent in starvation-induced autophagy, but failed to form double-membrane structures surrounding GAS, an essential step in xenophagy. This deficiency stemmed from reduced recruitment of ubiquitin and several core autophagy proteins in endothelial cells, as demonstrated by the fact that it could be rescued by exogenous coating of GAS with ubiquitin. The defect was associated with reduced NO-mediated ubiquitin signaling. Therefore, we propose that the lack of efficient clearance of GAS in endothelial cells is caused by their intrinsic inability to target GAS with ubiquitin to promote autophagosome biogenesis for xenophagy.
Solar system (2016)

Solar System implements smooth pursuit eye movement interactions on commercial smart glasses using electrooculography. The system requires no calibration and little to no training. We present a prototype implementation, describe initial user tests and show several application scenarios for hands-free eye gaze interactions.
Coexistence of LTE and radar system: Methodology and assessment of radar receivers (2018)

As the need to satisfy the global demand for wireless services continues, so does the pressure for valuable spectrum adjacent to radiolocation services is a topic of contention between incumbent spectrum users and national spectrum policy makers and regulators. Of particular interest and concern is the use of wireless services and the coexistence of UHF, L-, S-, and C-band radars and geo-location services. Existing studies on the coexistence of radar systems and modern LTE communications systems tend to focus on the measurements of the radar spectrum and the interference of the radar on the wireless base station receiver. In this presentation, a methodology and technique for benchmarking the radar receiver performance of cooperative radar systems in the presence of wireless systems is proposed, and some preliminary results are show for a commercial radar system.
Retroviral Scanning: Mapping MLV Integration Sites to Define Cell-specific Regulatory Regions (2017)

Moloney murine leukemia (MLV) virus-based retroviral vectors integrate predominantly in acetylated enhancers and promoters. For this reason, mLV integration sites can be used as functional markers of active regulatory elements. Here, we present a retroviral scanning tool, which allows the genome-wide identification of cell-specific enhancers and promoters. Briefly, the target cell population is transduced with an mLV-derived vector and genomic DNA is digested with a frequently cutting restriction enzyme. After ligation of genomic fragments with a compatible DNA linker, linker-mediated polymerase chain reaction (LM-PCR) allows the amplification of the virus-host genome junctions. Massive sequencing of the amplicons is used to define the mLV integration profile genome-wide. Finally, clusters of recurrent integrations are defined to identify cell-specific regulatory regions, responsible for the activation of cell-type specific transcriptional programs. The retroviral scanning tool allows the genome-wide identification of cell-specific promoters and enhancers in prospectively isolated target cell populations. Notably, retroviral scanning represents an instrumental technique for the retrospective identification of rare populations (e.g. somatic stem cells) that lack robust markers for prospective isolation.
Effects of surface termination on the band gap of ultrabrightSi29nanoparticles: Experiments and computational models (2002)

A ${\mathrm{Si}}_{29}{\mathrm{H}}_{24}$ particle, with five atoms constituting a tetrahedral core and 24 atoms constituting a H-terminated reconstructed Si surface was recently proposed as a structural prototype of ultrasmall ultrabright particles prepared by electrochemical dispersion from bulk Si. We replace the H termination with a N linkage (in butylamine) and O linkage (in pentane). The emission band for N-termination downshifts by \ensuremath{\sim}0.25 eV from that of H termination, whereas it blueshift \ensuremath{\sim}0.070 eV for C termination. We use density-functional approaches to calculate the atomic structures and correction from the quantum Monte Carlo method to estimate the highest occupied--lowest unoccupied molecular-orbital band gap. We find a downshift of 0.25 eV for N termination and very little for C termination. These features are discussed in terms of exciton penetration in the capping material.
Influence of Intravenous Perfluorocarbon Administration on the Dynamic Behavior of Lung Surfactant (1998)

Intravenous administration of perfluorocarbon (PFC) compounds can lead to pulmonary hyperinflation and respiratory distress in some mammals. This study was designed to quantify the effects of two PFC emulsions on the dynamic behavior of lung surfactant and to demonstrate that PFC is retained in the liquid lining the lung. New Zealand White rabbits received isotonic saline (3 ml/kg), Fluosol (15 ml/kg) or Oxygent (90% perfluorooctyl-bromide emulsion, 3 ml/kg). After seven days we euthanized the animals and lavaged the lungs. Surface tension-surface area relationships (sigma-A loops) were measured with the lavage fluid placed in a Wilhelmy plate-oscillating bellows apparatus. Loop hysteresis area after Fluosol administration was 334 +/- 92 dyne-cm, significantly greater than after saline (203 +/- 36 dyne-cm) but not Oxygent (274 +/- 66 dyne-cm). Loop hysteresis slope was higher with Oxygent (0.8 +/- 0.4 dyne/cm3) than after saline (0.6 +/- 0.3 dyne/cm3) or Fluosol (0.5 +/- 0.1 dyne/cm3). 282 MHz 19F NMR spectral analysis demonstrates that both PFCs tested appear only in the extracellular fraction of the lavage fluid. These results show that pulmonary elimination of intravascular PFC leads to PFC presence in the liquid lining the airways where it alters surfactant dynamic mechanical behavior.
Long-lasting complete response to imatinib in a patient with systemic mastocytosis exhibiting wild type KIT. (2014)

Systemic mastocytosis (SM) is a hematopoietic disorder characterized by abnormal expansion of mast cells (MCs) in visceral organs. The skin is involved in most cases. In adult patients the transforming KIT mutation D816V is usually present and confers resistance against imatinib. Therefore, imatinib is not recommended for patients with KIT D816V+ SM. Nonetheless, imatinib may work in patients with SM lacking KIT D816V. However, little is known about long-term efficacy and safety of this drug in SM. We report on a 62-year-old female patient with indolent SM (ISM) who suffered from severe debilitating skin involvement despite therapy with anti-mediator-type drugs, psoralen and ultraviolet-A-radiation. Although multifocal MC infiltrates were detected in the bone marrow by immunohistochemistry, no KIT mutation was found by sequencing analysis. In 2003, treatment with imatinib (induction, 400 mg/day; maintenance, 200 mg/day) was initiated. During therapy, skin lesions and tryptase levels decreased. Treatment was well tolerated without any side effects. After 10 years, skin lesions have disappeared and the tryptase level is within normal range. This case-study confirms the long-term efficacy and safety of imatinib in patients with SM lacking activating KIT mutations. Imatinib should be considered in select cases of SM in whom MCs exhibit wild-type KIT.