gebhart/patrepeval huggingface dataset:
Persistent, efficient frequency doubling by poled annealed films of a chromophore-functionalized poly(p-hydroxystyrene) (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPersistent, efficient frequency doubling by poled annealed films of a chromophore-functionalized poly(p-hydroxystyrene)C. Ye, N. Minami, T. J. Marks, J. Yang, and G. K. WongCite this: Macromolecules 1988, 21, 9, 2899–2901Publication Date (Print):September 1, 1988Publication History Published online1 May 2002Published inissue 1 September 1988https://pubs.acs.org/doi/10.1021/ma00187a046https://doi.org/10.1021/ma00187a046research-articleACS PublicationsRequest reuse permissionsArticle Views90Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Augmentation of a neuroprotective myeloid state by hematopoietic cell transplantation (2023)

Multiple sclerosis (MS) is an autoimmune disease associated with inflammatory demyelination in the central nervous system (CNS). Autologous hematopoietic cell transplantation (HCT) is under investigation as a promising therapy for treatment-refractory MS. Here we identify a reactive myeloid state in chronic experimental autoimmune encephalitis (EAE) mice and MS patients that is surprisingly associated with neuroprotection and immune suppression. HCT in EAE mice leads to an enhancement of this myeloid state, as well as clinical improvement, reduction of demyelinated lesions, suppression of cytotoxic T cells, and amelioration of reactive astrogliosis reflected in reduced expression of EAE-associated gene signatures in oligodendrocytes and astrocytes. Further enhancement of myeloid cell incorporation into the CNS following a modified HCT protocol results in an even more consistent therapeutic effect corroborated by additional amplification of HCT-induced transcriptional changes, underlining myeloid-derived beneficial effects in the chronic phase of EAE. Replacement or manipulation of CNS myeloid cells thus represents an intriguing therapeutic direction for inflammatory demyelinating disease.
Endogenous tumor necrosis factor-α contributes to lymphoproliferation induced by simian immunodeficiency virus variant, SIVsmmPBj14 (1998)

The simian immunodeficiency virus (SIV) isolate, SIVsmmPBj14, contains an immunoreceptor tyrosine-based activation motif (ITAM) within its nef gene product and triggers efficient lymphoproliferation in vitro. In experimentally inoculated macaque monkeys, this virus causes acutely lethal enteropathy, which is accompanied by high levels of pro-inflammatory cytokines, including tumor necrosis factor (TNF)-alpha. Since TNF-alpha has been shown to possess weak comitogenic activity for antigen- or mitogen-induced human T-cell proliferation, experiments were conducted to examine whether TNF-alpha might also contribute to SIVsmmPBj14-induced lymphoproliferation. Addition of a dimeric soluble human TNF receptor (sTNFR):Fc fusion protein to SIVsmmPBj14-infected simian peripheral blood mononuclear cells (PBMC) resulted in a partial (> 50%) inhibition of virally-induced lymphoproliferation, but had no effect on the strong T-cell activation signal provided by phytohemagglutinin and interleukin-2. Finally, the addition of exogenous human TNF-alpha to simian PBMC infected with a non-mitogenic variant of SIVsmmPBj14 failed to result in detectable lymphoproliferation, suggesting that TNF-alpha alone is not sufficient to cause the proliferation of SIV infected T-cells. Taken together, the data suggest that endogenous TNF-alpha enhances SIVsmmPBj14-induced lymphoproliferation in simian PBMC cultures.
Inhibition of tumor necrosis factor-induced cell killing by tryptophan and indole. (1991)

Cells sensitive to the cytocidal effect of tumor necrosis factor (TNF) were protected against this effect when growth in the presence of elevated concentrations of tryptophan. Several other indole derivatives also provided protection against TNF cytotoxicity. Most effective were indole itself and its monomethyl derivatives, providing a degree of protection greatly exceeding that observed with tryptophan. Protection was also observed against the cytocidal effect of TNF applied in the presence of a protein synthesis inhibitor. The protective effect of tryptophan was largely dependent on preexposure of the cells, for several hours, to a high concentration of this amino acid. On the other hand, indole was protective also when applied to cells together with TNF, or even two hours after TNF application. The inhibition of the cytotoxicity of TNF by tryptophan and other indole derivatives may serve as a useful experimental tool in exploring the mechanisms and the physiological implications of TNF cytotoxicity.
Data from Thy1-Targeted Microbubbles for Ultrasound Molecular Imaging of Pancreatic Ductal Adenocarcinoma (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; To engineer a dual human and murine Thy1-binding single-chain-antibody ligand (Thy1-scFv) for contrast microbubble–enhanced ultrasound molecular imaging of pancreatic ductal adenocarcinoma (PDAC).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Thy1-scFv were engineered using yeast-surface-display techniques. Binding to soluble human and murine Thy1 and to Thy1-expressing cells was assessed by flow cytometry. Thy1-scFv was then attached to gas-filled microbubbles to create MB&lt;sub&gt;Thy1-scFv&lt;/sub&gt;. Thy1 binding of MB&lt;sub&gt;Thy1-scFv&lt;/sub&gt; to Thy1-expressing cells was evaluated under flow shear stress conditions in flow-chamber experiments. MB&lt;sub&gt;scFv-scrambled&lt;/sub&gt; and MB&lt;sub&gt;Non-targeted&lt;/sub&gt; were used as negative controls. All microbubble types were tested in both orthotopic human PDAC xenografts and transgenic PDAC mice &lt;i&gt;in vivo&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Thy1-scFv had a &lt;i&gt;K&lt;/i&gt;&lt;sub&gt;D&lt;/sub&gt; of 3.4 ± 0.36 nmol/L for human and 9.2 ± 1.7 nmol/L for murine Thy1 and showed binding to both soluble and cellularly expressed Thy1. MB&lt;sub&gt;Thy1-scFv&lt;/sub&gt; was attached to Thy1 with high affinity compared with negative control microbubbles (&lt;i&gt;P&lt;/i&gt; &lt; 0.01) as assessed by flow cytometry. Similarly, flow-chamber studies showed significantly (&lt;i&gt;P&lt;/i&gt; &lt; 0.01) higher binding of MB&lt;sub&gt;Thy1-scFv&lt;/sub&gt; (3.0 ± 0.81 MB/cell) to Thy1-expressing cells than MB&lt;sub&gt;scFv-scrambled&lt;/sub&gt; (0.57 ± 0.53) and MB&lt;sub&gt;Non-targeted&lt;/sub&gt; (0.43 ± 0.53). &lt;i&gt;In vivo&lt;/i&gt; ultrasound molecular imaging using MB&lt;sub&gt;Thy1-scFv&lt;/sub&gt; demonstrated significantly higher signal (&lt;i&gt;P&lt;/i&gt; &lt; 0.01) in both orthotopic (5.32 ± 1.59 a.u.) and transgenic PDAC (5.68 ± 2.5 a.u.) mice compared with chronic pancreatitis (0.84 ± 0.6 a.u.) and normal pancreas (0.67 ± 0.71 a.u.). &lt;i&gt;Ex vivo&lt;/i&gt; immunofluorescence confirmed significantly (&lt;i&gt;P&lt;/i&gt; &lt; 0.01) increased Thy1 expression in PDAC compared with chronic pancreatitis and normal pancreas tissue.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; A dual human and murine Thy1-binding scFv was designed to generate contrast microbubbles to allow PDAC detection with ultrasound. &lt;i&gt;Clin Cancer Res; 24(7); 1574–85. ©2018 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Comparison of intravesical botulinum toxin type A injections plus hydrodistention with hydrodistention alone for the treatment of refractory interstitial cystitis/painful bladder syndrome (2009)

Intravesical injections of BoNT-A followed by HD produced significantly better clinical results than HD alone in patients with IC/PBS.
Preload-responsive adhesion: effects of aspect ratio, tip shape and alignment (2013)

We tested the adhesive response of polymer surfaces structured with arrays of cylindrical fibrils having diameters of 10-20 µm and aspect ratios 1-2.4. Fibrils had two different tip shapes of end-flaps and round edges. A preload-induced mechanical buckling instability of the fibrils was used to switch between the states of adhesion and non-adhesion. Non-adhesion in fibrils with round edges was reached at preloads that caused fibril buckling, whereas fibrils with end-flaps showed adhesion loss only at very high preloads. The round edge acted as a circumferential flaw prohibiting smooth tip contact recovery leading to an adhesion loss. In situ observations showed that, after reversal of buckling, the end-flaps unfold and re-form contact under prevailing compressive stress, retaining adhesion in spite of buckling. At very high preloads, however, end-flaps are unable to re-form contact resulting in adhesion loss. Additionally, the end-flaps showed varying contact adaptability as a function of the fibril-probe alignment, which further affects the preload for adhesion loss. The combined influence of preload, tip shape and alignment on adhesion can be used to switch adhesion in bioinspired fibrillar arrays.
An integrated segmentation and shape-based classification scheme for distinguishing adenocarcinomas from granulomas on lung CT (2017)

The major finding of this study was that certain shape features appear to differentially express between granulomas and adenocarcinomas and thus computer extracted shape cues could be used to distinguish these radiographically similar pathologies.
45.4: Wide Viewing‐Angle Polarizers Having Relaxed Manufacturing Tolerances (2006)

Abstract Improved wide viewing‐angle polarizers are proposed that employ symmetrically identical compensator designs having relaxed manufacturing tolerances relative to their orientation to the transmission axis of the polarizer. These designs can be realized in numerous ways and can comprise two A‐plates, one A‐plate and one C‐plate, or one biaxial plate.
Improvement of Hydraulic and Water Quality Renovation Functions by Intermittent Aeration of Soil Treatment Areas in Onsite Wastewater Treatment Systems (2010)

We tested intermittent aeration of the soil treatment area (STA) of onsite wastewater treatment systems (OWTS) for its ability to restore and maintain STA hydraulic flow and improve the water quality functions of conventional OWTS. Evaluation was conducted on hydraulically-failed conventional OWTS at three state-owned medical group homes in Washington County, RI, USA. Testing was conducted in two phases, with Phase I (before intermittent soil aeration (ISA)) comprising the first 6 months of the study, and Phase II (during ISA) the remaining 7 months. Intermittent soil aeration restored STA hydraulic function in all three systems despite a marked reduction in the STA total infiltrative surface. Soil pore water was collected from 30 and 90 cm below the STA during both phases and analyzed for standard wastewater parameters. Although the STA infiltrative surface was reduced—and the contaminant load per unit of area increased—after installation of the ISA system, no differences were observed between phases in concentration of total N, NO3, total P, or dissolved organic carbon (DOC). Apparent removal rates—which do not account for dilution or differences in infiltrative area—for total N, total P, and DOC remained the same or improved during Phase II relative to the pre-operation phase. Furthermore, intermittent soil aeration enhanced actual removal rates —which do account for dilution and differences in infiltrative area. The effects of ISA on actual removal of contaminants from STE increased with increasing hydraulic load—a counterintuitive phenomenon, but one that has been previously observed in laboratory studies. The results of our study suggest that intermittent soil aeration can restore and maintain hydraulic flow in the STA and enhance carbon and nutrient removal in conventional OWTS.
Nanostructured CaCO3 Thin Films Formed on the Urease Multilayers Prepared by the Layer-by-Layer Deposition (2009)

Nanostructured CaCO3 (NCC) thin films with honeycomb-shaped nanopores were obtained at the surface of urease-embedded multilayers prepared by the layer-by-layer deposition. Amorphous CaCO3 (ACC) droplets were initially nucleated from the multilayer surface, because of the enzymatic reaction of ureases to produce CO2, particularly when the saturation index of CaCO3 in the crystal-forming solution is above 1.89 based on the calcite saturation. Once ACC droplets successfully covered the entire surface of the urease multilayers, the ACC layers underwent the transformation into the crystalline {104}-faceted nanostructured calcite thin films with square pores, ∼30 nm on each side, in a humidity-controlled chamber. Furthermore, such NCC thin films were realized on various substrates (two-dimensional patterns, PS microspheres, and sawtooth-shaped three-dimensional patterns) taking full advantage of the conformal multilayer coating capability of the layer-by-layer deposition.
All-Polymer Solar Cells Incorporating Readily Accessible Naphthalene Diimide and Isoindigo Acceptor Polymers for Improved Light Harvesting (2022)

The development of readily accessible polymer acceptors is imperative to preserve the guiding principles of all-polymer solar cells as a low-cost and sustainable technology for alternative energy production. In this study, we report a computationally guided design and facile synthesis of new acceptor polymers comprising the alternating copolymer, PNIT, and the corresponding random copolymer, r-PNIT, which incorporate structurally simple naphthalene diimide (NDI) and isoindigo (IID) units. PNIT was prepared via direct arylation polymerization (DArP), which proceeds via C–H activation and avoids the use of toxic reagents and extended synthetic pathways for the monomer synthesis. PNIT has broad optical absorption in the 300–850 nm range and an enhanced absorption coefficient (47 × 103 cm–1) compared to r-PNIT (300–850 nm; 40 × 103 cm–1). When incorporated in all-polymer solar cells (APSCs) using PBDB-T as the donor polymer, PBDB-T:PNIT provides greater than two times the average (maximum) power conversion efficiency (PCE) of 5.18 ± 0.08 (5.32)% compared to that of PBDB-T:r-PNIT, 2.38 ± 0.16 (2.57)%, due to increased Jsc (10.36 vs 5.45 mA cm–2) and fill factor (FF) (0.58 vs 0.50) metrics. The PBDB-T:PNIT PCE is among the highest reported for an IID-based APSC and demonstrates the viability of DArP for the synthesis of new APSC acceptor polymers. Detailed morphological and microstructural investigations using atomic force microscopy (AFM) and grazing-incidence wide-angle X-ray scattering (GIWAXS), respectively, reveal enhanced texturing for PNIT, which enhances charge transport properties as supported by space-charge-limited current (SCLC) mobility measurements.
Graphene‐Based Actuators (2009)

A bilayer “paper,” composed of adjacent graphene oxide and MWCNT layers each approximately 10-µm thick, is fabricated by simple sequential filtration of an aqueous suspension of MWCNTs and then graphene oxide platelets, and demonstrated as the first case of a macroscopic graphene-based actuator. The papers curl (see image) depending on humidity and/or temperature.
Mutations in AtPS1 (Arabidopsis thaliana Parallel Spindle 1) Lead to the Production of Diploid Pollen Grains (2008)

Polyploidy has had a considerable impact on the evolution of many eukaryotes, especially angiosperms. Indeed, most--if not all-angiosperms have experienced at least one round of polyploidy during the course of their evolution, and many important crop plants are current polyploids. The occurrence of 2n gametes (diplogametes) in diploid populations is widely recognised as the major source of polyploid formation. However, limited information is available on the genetic control of diplogamete production. Here, we describe the isolation and characterisation of the first gene, AtPS1 (Arabidopsis thaliana Parallel Spindle 1), implicated in the formation of a high frequency of diplogametes in plants. Atps1 mutants produce diploid male spores, diploid pollen grains, and spontaneous triploid plants in the next generation. Female meiosis is not affected in the mutant. We demonstrated that abnormal spindle orientation at male meiosis II leads to diplogamete formation. Most of the parent's heterozygosity is therefore conserved in the Atps1 diploid gametes, which is a key issue for plant breeding. The AtPS1 protein is conserved throughout the plant kingdom and carries domains suggestive of a regulatory function. The isolation of a gene involved in diplogamete production opens the way for new strategies in plant breeding programmes and progress in evolutionary studies.
ChemInform Abstract: Photochemistry of Hydroxy Aromatic Compounds (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Navigating Performance, Portability, and Productivity (2021)

The phrase “performance portability” is commonly used, but may mean different things to different people. Developing a better appreciation of the needs of different software developers and a framework for talking about these needs improves our ability to define goals, design experiments, and make forward progress. This article discusses a methodology for quantifying, summarizing, visualizing, and understanding application performance portability, and programmer productivity.
Nicked-sleeve interface for two-dimensional capillary electrophoresis (2013)

We report an improved interface for two-dimensional capillary electrophoresis. This interface is based on capillary tubing and a Plexiglas chip, both of which were milled using a micro-dicing saw. The interface was evaluated and compared to a traditional interface design for both pseudo one-dimensional and two-dimensional capillary electrophoresis. We observe less than 70% transfer efficiency for the traditional design and greater than 90% transfer efficiency with this new interface.
Adaptive Robust Motion and Force Tracking Control of Robot Manipulators in Contact With Stiff Surfaces (1996)

Abstract High performance robust motion and force tracking control of robot manipulators in contact with stiff surfaces is considered in this paper. The robot parameters and the stiffness of the contact surface may not be known. The system may also be subjected to uncertain nonlinearities coming from the joint friction of the robot, external disturbances, the contact surface friction model, and the unknown time-varying equilibrium position of the contact surface. An adaptive robust motion and force controller is proposed, which needs measurements of position, velocity and interaction force only. The controller achieves a guaranteed transient performance and final tracking accuracy, a desirable feature for applications and for maintaining contact. In addition, the controller achieves asymptotic motion and force tracking without resorting to high-gain feedback when the system is subjected to parametric uncertainties only.
Speech recognition performance on a voicemail transcription task (2002)

We describe a new testbed for developing speech recognition algorithms-the ARRPA-sponsored voicemail transcription task, analogous to other tasks such as the Switchboard, CallHome and the Hub 4 tasks. The task involves the transcription of voicemail conversations. Voicemail represents a very large volume of real-world speech data, which is however not particularly well represented in existing databases. For instance, the Switchboard and CallHome databases contain telephone conversations between two humans, representing telephone-bandwidth spontaneous speech; the Hub 4 database contains radio broadcasts which represents different kinds of speech data such as spontaneous speech from a well-trained speaker, conversations between two humans possibly over the telephone, etc. The voicemail database on the other hand also represents telephone bandwidth spontaneous speech, however the difference with respect to the Switchboard and CallHome tasks is that the interaction is not between two humans, but rather between a human and a machine-consequently, the speech is expected to be a little more formal in its nature, without the problems of crosstalk, barge-in etc. This eliminates some of the variables and provides more controlled conditions enabling one to concentrate on the aspects of spontaneous speech and effects of the telephone channel. We describe the modality of collection of the speech data, and some algorithmic techniques that were devised based on this data. We also describe the initial results of the transcription performance on this task.
Synthesis of Gold Square‐like Plates from Ultrathin Gold Square Sheets: The Evolution of Structure Phase and Shape (2011)

Fast quadratisch: Quadrat-ähnliche Goldplättchen mit abwechselnd hexagonal-dichtester (hcp, gelb im Bild) und kubisch-flächenzentrierter Struktur (fcc, rot) im Zentrum und defektfreier fcc-Struktur an zwei gegenüberliegenden dicken Kanten können aus quadratischen Goldplättchen durch einen sekundären Wachstumsprozess erhalten werden. Hierbei wurde erstmals ein hcp→fcc-Phasenübergang unter Formänderung in Goldnanostrukturen nachgewiesen.
Quantum and statistical mechanical studies of liquids. 10. Transferable intermolecular potential functions for water, alcohols, and ethers. Application to liquid water (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantum and statistical mechanical studies of liquids. 10. Transferable intermolecular potential functions for water, alcohols, and ethers. Application to liquid waterWilliam L. JorgensenCite this: J. Am. Chem. Soc. 1981, 103, 2, 335–340Publication Date (Print):January 1, 1981Publication History Published online1 May 2002Published inissue 1 January 1981https://pubs.acs.org/doi/10.1021/ja00392a016https://doi.org/10.1021/ja00392a016research-articleACS PublicationsRequest reuse permissionsArticle Views3920Altmetric-Citations1079LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts