gebhart/patrepeval huggingface dataset:
Core−Shell Materials Elaboration in Supercritical Mixture CO2/Ethanol (2000)

Supercritical fluids exhibit a range of unusual properties that can be exploited for developing new processes. In this paper a new way for particle coating is presented. It consists of depositing on a core particle a thin layer of a material based on copper in a supercritical medium. Two examples are described: a deposit of Cu on nickel particles and a deposit of Cu on particles of permanent magnet SmCo5. In both cases the copper source is bis(hexafluoroacetylacetonate)copper(II), which is thermally decomposed in the supercritical mixture CO2/ethanol. This process allows one to obtain new “core−shell structures”, Ni/Cu and SmCo5/Cu. New interesting properties are expected for these structures, more particularly in the magnetic recording field.
The Optical Janus Effect: Asymmetric Structural Color Reflection Materials (2017)

Structurally colored materials are often used for their resistance to photobleaching and their complex viewing-direction-dependent optical properties. Frequently, absorption has been added to these types of materials in order to improve the color saturation by mitigating the effects of nonspecific scattering that is present in most samples due to imperfect manufacturing procedures. The combination of absorbing elements and structural coloration often yields emergent optical properties. Here, a new hybrid architecture is introduced that leads to an interesting, highly directional optical effect. By localizing absorption in a thin layer within a transparent, structurally colored multilayer material, an optical Janus effect is created, wherein the observed reflected color is different on one side of the sample than on the other. A systematic characterization of the optical properties of these structures as a function of their geometry and composition is performed. The experimental studies are coupled with a theoretical analysis that enables a precise, rational design of various optical Janus structures with highly controlled color, pattern, and fabrication approaches. These asymmetrically colored materials will open applications in art, architecture, semitransparent solar cells, and security features in anticounterfeiting materials.
IL‐4 downregulates expression of the target receptor CD30 in neoplastic canine mast cells (2016)

CD30 is a novel therapeutic target in human mast cell (MC) neoplasms. In this 'comparative oncology' study, we examined CD30 expression and regulation in neoplastic canine MC using a panel of immunomodulatory cytokines [interleukin-2 (IL-2), IL-4, IL-5, IL-6, IL-13 and stem cell factor (SCF)] and the canine mastocytoma cell lines NI-1 and C2. Of all cytokines tested IL-4 was found to downregulate expression of CD30 in NI-1 and C2 cells. We also found that the CD30-targeting antibody-conjugate brentuximab vedotin induces growth inhibition and apoptosis in both MC lines. Next, we asked whether IL-4-induced downregulation of CD30 interferes with brentuximab vedotin-effects. Indeed, pre-incubation of NI-1 cells with IL-4 decreased responsiveness towards brentuximab vedotin. To overcome IL-4-mediated resistance, we applied drug combinations and found that brentuximab vedotin synergizes with the Kit-targeting drugs masitinib and PKC412 in inhibiting growth of NI-1 and C2 cells. In summary, CD30 is a new marker and IL-4-regulated target in neoplastic canine MC.
Improved benzene production from methane dehydroaromatization over Mo/HZSM-5 catalysts via hydrogen-permselective palladium membrane reactors (2015)

Catalytic Pd membrane reactors improve C<sub>6</sub>H<sub>6</sub>yield compared to fixed-bed reactors.
In Vitro Strategies to Vascularize 3D Physiologically Relevant Models (2021)

Vascularization of 3D models represents a major challenge of tissue engineering and a key prerequisite for their clinical and industrial application. The use of prevascularized models built from dedicated materials could solve some of the actual limitations, such as suboptimal integration of the bioconstructs within the host tissue, and would provide more in vivo-like perfusable tissue and organ-specific platforms. In the last decade, the fabrication of vascularized physiologically relevant 3D constructs has been attempted by numerous tissue engineering strategies, which are classified here in microfluidic technology, 3D coculture models, namely, spheroids and organoids, and biofabrication. In this review, the recent advancements in prevascularization techniques and the increasing use of natural and synthetic materials to build physiological organ-specific models are discussed. Current drawbacks of each technology, future perspectives, and translation of vascularized tissue constructs toward clinics, pharmaceutical field, and industry are also presented. By combining complementary strategies, these models are envisioned to be successfully used for regenerative medicine and drug development in a near future.
Interaction of Droplets Separated by an Elastic Film (2016)

The Laplace pressure of a droplet placed on one side of an elastic thin film can cause significant deformation in the form of a bulge on its opposite side. Here, we show that this deformation can be detected by other droplets suspended on the opposite side of the film, leading to interaction between droplets separated by the solid (but deformable) film. The interaction is repulsive when the drops have a large overlap and attractive when they have a small overlap. Thus, if two identical droplets are placed right on top of each other (one on either side of the thin film), they tend to repel each other, eventually reaching an equilibrium configuration where there is a small overlap. This observation can be explained by analyzing the energy landscape of the droplets interacting via an elastically deformed film. We further demonstrate this idea by designing a pattern comprising a big central drop with satellite droplets. This phenomenon can lead to techniques for directed motion of droplets confined to one side of a thin elastic membrane by manipulations on the other side.
Targeting the MTF2–MDM2 Axis Sensitizes Refractory Acute Myeloid Leukemia to Chemotherapy (2018)

Deep sequencing has revealed that epigenetic modifiers are the most mutated genes in acute myeloid leukemia (AML). Thus, elucidating epigenetic dysregulation in AML is crucial to understand disease mechanisms. Here, we demonstrate that metal response element binding transcription factor 2/polycomblike 2 (MTF2/PCL2) plays a fundamental role in the polycomb repressive complex 2 (PRC2) and that its loss elicits an altered epigenetic state underlying refractory AML. Unbiased systems analyses identified the loss of MTF2-PRC2 repression of MDM2 as central to, and therefore a biomarker for, refractory AML. Thus, immature MTF2-deficient CD34<sup>+</sup>CD38<sup>-</sup> cells overexpress MDM2, thereby inhibiting p53 that leads to chemoresistance due to defects in cell-cycle regulation and apoptosis. Targeting this dysregulated signaling pathway by MTF2 overexpression or MDM2 inhibitors sensitized refractory patient leukemic cells to induction chemotherapeutics and prevented relapse in AML patient-derived xenograft mice. Therefore, we have uncovered a direct epigenetic mechanism by which MTF2 functions as a tumor suppressor required for AML chemotherapeutic sensitivity and identified a potential therapeutic strategy to treat refractory AML.<b>Significance:</b> MTF2 deficiency predicts refractory AML at diagnosis. MTF2 represses MDM2 in hematopoietic cells and its loss in AML results in chemoresistance. Inhibiting p53 degradation by overexpressing MTF2 <i>in vitro</i> or by using MDM2 inhibitors <i>in vivo</i> sensitizes MTF2-deficient refractory AML cells to a standard induction-chemotherapy regimen. <i>Cancer Discov; 8(11); 1376-89. ©2018 AACR.</i> <i>See related commentary by Duy and Melnick, p. 1348</i> <i>This article is highlighted in the In This Issue feature, p. 1333</i>.
A control strategy for optimizing the power flows supplied by two different storage units (2011)

The DC distribution networks can easily benefit from integration of electrical storage systems, such as batteries and supercapacitors, to manage the network operations. A proper combination of these two storage units can lead to a storage system able to satisfy power requests lasting from seconds to hours. However, the use of more than one storage unit gives rise to the problem of deciding how to split the power between the two technologies. In the paper, authors propose a control strategy to divide the power demand between the two storage units ensuring, at the same time: i) a peak shaving action for the interface converter opportunely slowed; ii) the lifetime increase of storage units by means of a proper control adapted to the dynamic performances of each storage device; iii) the keeping of the state of charge of each unit around a desired value. In the paper, the effectiveness of the proposed strategy is shown by means of numerical simulations. In particular, very good results are obtained also when the power demand is completely random.
Chiral-Auxiliary-Mediated Asymmetric Synthesis of Tris-Heteroleptic Ruthenium Polypyridyl Complexes (2009)

A strategy for the asymmetric synthesis of chiral-at-metal [Ru(pp)(pp')(pp'')](2+) complexes, where pp, pp', and pp'' are achiral 2,2'-bipyridines, is introduced. The method employs isopropyl-2-(2'-hydroxyphenyl)oxazolines as chiral auxiliaries, which serve in their deprotonated forms as strong bidentate ligands that provide excellent asymmetric induction in the course of the coordination chemistry and, importantly, can afterward become substituted with complete retention of configuration in the presence of acid.
Ultimate limit of nanoplasmonic field enhancement(Conference Presentation) (2016)

The fact that surface-induced damping rate of surface plasmon polaritons (SPPs) in metal nanoparticles increases with the decrease of particle size is well known. This damping effect introduces additional loss to that of bulk metal and results in smaller enhancement of luminescence. We show that this rate also increases with the degree of the mode confinement, hence damping of the higher order nonradiative SPP modes in spherical particles is greatly enhanced relative to damping of the fundamental (dipole) SPP mode. Since higher order modes are the ones responsible for quenching of luminescence in the vicinity of metal surfaces, the degree of quenching increases resulting in a substantial decrease in the amount of attainable enhancement of the luminescence.
Computed tomography-guided neurolytic celiac plexus block with alcohol complicated by superior mesenteric venous thrombosis (2001)

Neurolytic celiac plexus block (CPB) under radiological guidance is often performed to manage pain associated with pancreatic cancer. Serious complications related to the block are rare. Computed Tomography (CT)-guided neurolytic CPB is advocated to improve the efficacy of the block and to reduce the incidence of associated complications. We describe a case of superior mesenteric vein thrombosis associated with neurolytic CPB performed under CT guidance.
Fluoride release and dentin caries inhibition adjacent to resin-modified glass-ionomer luting cements (2005)

The objectives of this investigation were to compare the fluoride release and caries inhibition ability of resin-modified glass ionomer (RMGI) luting cements. Methods: Materials used for dentin caries inhibition were 3M ESPE RelyX(superscript TM) Luting Plus Cement (REP) paste-paste RMGI, RelyX(superscript TM) Luting Cement (RLC) powder-liquid RMGI and Filtek(superscript TM) Z250 composite/Adper(superscript TM) Single Bond adhesive (ZSB). Rectangular slots (6×2×1 mm) were prepared in 24 dentin blocks cut from 8 bovine roots, and filled with ZSB, RLC, and REP. The specimens were immersed in 10 ml acetic acid solution pH 5.0 (37℃, 3 wks) to create artificial dentin lesion, then sectioned into 400 μm slices and subjected to microradiography. Mineral loss (△Z) was calculated from mineral profiles at 0.5 and 1.0 mm from the material margin, and statistically analyzed (ANOVA, Fisher's, p＜0.05). Fluoride release from cured cement discs (20×1 mm; n=8) in distilled water was measured after 1, 7, 14, 28, 90, 180, and 365 day using F-specific electrode and TISAB buffer. A conventional GIC, Ketac(superscript TM) Cem, was used as a control for this experiment. Results: Z250 is not fluoridated and did not exhibit F release. The sustained F release from REP and REC were comparable to each other and higher than from the control conventional GIC. Both RMGIs showed pronounced inhibition zones in dentin adjacent to cement margin. △Z values at 0.5 mm and 1.0 mm from RLP and RLC were significantly less compared to ZSB. △Z values were not significantly different in RLP and RLC groups at 1.0 mm. Conclusion: Both the powder-liquid and paste-paste RMGIs, RelyX Luting and RelyX Luting Plus cements respectively, released comparable amounts of fluoride, and, in contrast to the composite, demonstrated inhibition zones at the adjacent dentin when subjected to in vitro demineralization. Both cements inhibited mineral loss in dentin compared to the composite up to 1.0 mm adjacent to the bonded interface.
Designing collective behavior in a group of humans using a real-time polling system and interactive evolution (2005)

Interactive evolutionary design, a powerful technique where one marries the exploratory capabilities of evolutionary computation with the aesthetic skills and domain knowledge of the human as selective agent, has been demonstrated to be an extremely powerful exploratory design method. One of interactive evolutions most promising uses is in discovering individual-level rules of behavior and interaction that will produce a desired collective pattern in a group of human or non-human agents. The problem of finding micro-rules that produce interesting macro-behavior poses significant challenges, all the more so when what constitutes "interesting" macro-behavior may not be known ahead of time. Here, the system at our disposal is a real-time crowd polling and display system, whose potential for generating interesting group behavior remains largely untapped. Additionally, because the system is capable of polling large crowds of people in real time, it presents an ideal framework within which to take advantage of a relatively unexplored form of interactive evolution - collective evolution, where the opinions of the entire group are taken into account in the design of the next generation. Collective evolution has a broad range of potential applications, including marketing research and logo and brand name design.
Trends in Integration for Magnetically Levitated Pump Systems (2007)

Highly compact magnetically levitated pump systems are of growing interest in semiconductor processing applications due to the increasing costs of clean room space. The need of a higher hydraulic pressure in a smaller mounting volume raises the necessity of a complete integration of the power and signal electronics together with the motor and the pump into one compact system. Thereby, the system complexity is increased in the first instance and problematic issues such as thermal interaction between the system parts and overheating have to be solved. However, the integration opens the door for an optimization of the complete system. Based on a thermal model and on analytical relations between the hydraulic, electric and mechanical system variables the integrated pump system is optimized aiming for maximum pressure density. Exemplarily, the optimum point is calculated for an existing magnetically levitated pump and the dependency of the hydraulic efficiency is discussed.
Template-Assisted Deposition of Palladium Nanoarrays (2005)

An in situ, easy, and versatile method to decorate a polymer substrate with uniformly spaced centimeter-long arrays of 5-10 nm palladium nanoparticles is reported. The electrochemical deposition of palladium nanoarrays is described as well as results from various microscopic and spectroscopic characterizations, such as transmission electron microscopy, scanning electron microscopy, optical microscopy, and electron spectroscopy for chemical analysis for their size, morphology, chemical constituent, and chemical state, respectively. The Pd nanoarrays were synthesized using a special kind of active template from an electrolyte solution of ionic strength 0.10626 mol g-1. The effect of curvature on the active template is discussed briefly. Understanding of the preferentially deposited Pd nanoparticles to form nanoarrays longitudinally under controlled conditions can lead to the preparation of low-cost, lightweight, reliable hydrogen sensors for safety monitoring applications. © 2005 The Electrochemical Society. All rights reserved.
Digital direct detection of microRNAs using single molecule arrays (2017)

MicroRNAs (miRNAs) are involved in many biological pathways, and detecting miRNAs accurately is critical for diagnosing a variety of diseases including cancer. However, most current methods for miRNA detection require lengthy sample preparation and amplification steps that can bias the results. In addition, lack of specificity and reproducibility give rise to various challenges in detection of circulating miRNAs in biological samples. In this work, we applied the Single Molecule Array (Simoa) technique to develop an ultra-sensitive sandwich assay for direct detection of multiple miRNAs without pre-amplification. We successfully detected miRNAs at femtomolar concentrations (with limits of detection [LODs] ranging from 1 to 30 fM) and high specificity (distinguishing miRNAs with a single nucleotide mismatch). This method was effective against a range of diverse target sequences, suggesting a general approach for miRNA detection. To demonstrate the practical application of this technique, we detected miRNAs in a variety of sample types including human serum and total RNA. The high sensitivity and simple workflow of the Simoa method represent excellent advantages for miRNA-based diagnostics of human diseases.
Quantification of acute myocardial injury in STEMI patients post revascularization at 3Tesla. Comparison of T1-mapping, late gadolinium and edema imaging (2011)

To quantify myocardial injury in patients with acute STelevation myocardial infarcts (STEMI) by T1-mapping using Shortened Modified Look-Locker Inversion Recovery (ShMOLLI).
Regulation of core expression during the hepatitis C virus life cycle (2014)

Core plays a critical role during hepatitis C virus (HCV) assembly, not only as a structural component of the virion, but also as a regulator of the formation of assembly sites. In this study, we observed that core is expressed later than other HCV proteins in a single viral cycle assay, resulting in a relative increase of core expression during a late step of the viral life cycle. This delayed core expression results from an increase of core half-life, indicating that core is initially degraded and is stabilized at a late step of the HCV life cycle. Stabilization-mediated delayed kinetics of core expression were also observed using heterologous expression systems. Core stabilization did not depend on its interaction with non-structural proteins or lipid droplets but was correlated with its expression levels and its oligomerization status. Therefore in the course of a HCV infection, core stabilization is likely to occur when the prior amplification of the viral genome during an initial replication step allows core to be synthesized at higher levels as a stable protein, during the assembly step of the viral life cycle.
A Sliding Scale Signal Quality Metric of Photoplethysmography Applicable to Measuring Heart Rate across Clinical Contexts with Chest Mounting as a Case Study (2023)

This proof-of-concept work demonstrates an effective approach for assessing signal quality and demonstrates the effect of poor signal quality on HR measurement. Our continuous signal quality metrics allow estimations of uncertainties in other emergent metrics, such as energy expenditure that relies on multiple independent biometrics. This open-source approach increases the availability and applicability of our work in public health settings.
Update on the ESCEO recommendation for the conduct of clinical trials for drugs aiming at the treatment of sarcopenia in older adults (2020)

The working group has formulated consensus recommendations on specific aspects of trial design, and in doing so hopes to contribute to an improvement of the methodological robustness and comparability of clinical trials. Standardization of designs and outcomes would advance the field by allowing better comparison across studies, including performing individual patient-data meta-analyses, and different pro-myogenic therapies.
Perceptual Audio Coding with Adaptive Non-uniform Time/frequency Tilings Using Subband Merging and Time Domain Aliasing Reduction (2019)

In this paper, we investigate the coding efficiency of perceptual coding using an adaptive non-uniform orthogonal filter-bank based on MDCT analysis/synthesis and time domain aliasing reduction. We compare its performance to a system using a traditional adaptive uniform MDCT filterbank with window switching. The comparison is performed using a listening test at two different quantization settings. The statistical evaluation shows that the percetpual quality of the nonuniform filterbank significantly out-performs that of the uniform filterbank by 5 to 10 MUSHRA points.
Target sequences for cis-acting regulation within the dual promoter of the human c-myc gene. (1987)

Recombinant plasmids of the human c-myc promoter-leader region and the bacterial chloramphenicol acetyltransferase (cat) gene were constructed. After transfection into different rodent and human cells, the 862-base-pair (bp) PvuII fragment carrying both c-myc promoters and 350 bp of the untranslated leader conferred 1/15 to 1/30 of the CAT activity mediated by the simian virus 40 promoter. The presence of additional sequences upstream of the PvuII fragment had an overall negative effect on c-myc promoter activity detectable by titration analysis with small amounts of transfected plasmid DNA. The analysis of numerous deletion constructs in the c-myc promoter-leader region as well as S1 mapping experiments demonstrated that the high CAT activity depended largely on the presence of the second promoter. By cotransfection of c-myc-cat constructs with plasmids carrying different parts of the c-myc promoter locus, targets for positively acting cellular factors were identified. Two positive regulatory elements were mapped within the 862-bp PvuII fragment. One was localized within the 248-bp PvuII-SmaI fragment -101 to -349 bp upstream of the first cap site and the other within the 142-pb XhoI-NaeI fragment of the first exon, comprising positions -95 to +47 relative to the second cap site. We conclude that the dual promotor of the human c-myc gene represents a strong eucaryotic promotor regulated by cooperation of positively and negatively acting cellular transcription factors.
Remote timed up and go evaluation from activities of daily living reveals changing mobility after surgery (2019)

Remote TUG can be estimated in older adults using 3-days of ADLs data recorded using a wearable pendant. Remote TUG has discriminatory potential for identifying frail elderly and may provide a convenient way to monitor changes in mobility in unsupervised settings.