gebhart/patrepeval huggingface dataset:
First-Principles Calculations of Structural Changes Induced by Oxygen Vacancies in Tetragonal Phase BaTiO<sub>3</sub> (2011)

Structural changes induced by oxygen vacancies in tetragonal phase BaTiO 3 are studied with first principles calculations within density functional theory. In our calculations, the incorporation of oxygen vacancies greatly decreases c/a ratio of the tetragonal phase BaTiO 3 , and a phase transition from tetragonal to cubic phase occurs when the incorporation of the oxygen vacancies reaches about 4%. Our results also shows that the generation of the oxygen vacancies slightly increases the volume of BaTiO 3 , and the increases are typically less than 0.5% even in heavily reduced conditions.
Carbon Nanotubes: Synthesis of Carbon Nanotube Incorporated Metal Oxides for the Fabrication of Printable, Flexible Nickel‐Zinc Batteries (Adv. Mater. Interfaces 4/2018) (2018)

Flexible batteries are a key component for the next generation electronics such as wearable sensors and bendable screens. Printable, composite electrodes embedded with multi-walled carbon nanotubes are developed for flexible nickel-zinc batteries, where the direct loading of active ingredients on carbon nanotubes facilitates charge transport. This is reported by Somenath Mitra and co-workers in article number 1701036.
Comparison of RTV silicone rubber coatings under artificial contamination in a fog chamber (1992)

A comparison is presented of the electrical performance of room-temperature vulcanized (RTV) silicone rubber coatings for insulators under artificial contamination produced in a salt-fog chamber with DC voltage. Comparison of the RTV coatings with silicone grease coating has also been made. Correlation of the electrical parameters, such as leakage current and flashover voltage, with material degradation due to aging produced by dry band arcing is established. It is demonstrated that there are distinct differences among the RTV coatings evaluated, and between RTV coatings and silicon grease.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Ferritin heavy chain is a negative regulator of ovarian cancer stem cell expansion and epithelial to mesenchymal transition (2016)

In this paper we uncover a new function of FHC in the control of cancer stem cells.
Magnetic force microscopy study of interactions in 100 nm period nanomagnet arrays (2000)

The magnetic behavior of two different 100 nm period arrays of Ni pillars has been characterized using vibrating sample magnetometry and magnetic force microscopy. The samples have similar aspect ratios of approximately two but different particle dimensions, leading to differences in the strength of magnetostatic interactions. The experimental results were compared with a simulation based on an Ising-like simple interaction model.
Dietary Flavonoids, CYP1A1 Genetic Variants, and the Risk of Colorectal Cancer in a Korean population (2017)

The role of dietary flavonoid intake in colorectal carcinogenesis might differ according to flavonoid subclasses and individual genetic variants related to carcinogen metabolism. Therefore, we examined whether greater dietary intake of flavonoid subclasses was associated with a lower risk of colorectal cancer and whether CYP1A1 genetic variants altered this association. A semi-quantitative food frequency questionnaire was used to assess the dietary intake of six flavonoid subclasses (flavonols, flavones, flavanones, flavan-3-ols, anthocyanidins, and isoflavones) in 923 patients with colorectal cancer and 1,846 controls; furthermore, CYP1A1 genetic variants (rs4646903 and rs1048943) were genotyped. Among the subclasses of flavonoids, higher intake of flavonols and flavan-3-ols showed a stronger association with a reduced risk of colorectal cancer after adjusting for potential confounding factors. Carriers of the CYP1A1 rs4646903 CC homozygous variant showed a reduced risk of rectal cancer compared with that in TT carriers. The inverse association between dietary flavonol intake and colorectal cancer risk was stronger among carriers of the CC homozygous variant than among T allele carriers (P for interaction = 0.02), particularly for rectal cancer (P for interaction = 0.005). In conclusion, the effect of dietary flavonoid intake on colorectal cancer risk differs according to flavonoid subclasses and CYP1A1 genetic variants.
Thermal and Spectroscopic Analysis of a Fatty Acid-Layered Double-Metal Hydroxide and Its Application as a Chromatographic Stationary Phase (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermal and Spectroscopic Analysis of a Fatty Acid-Layered Double-Metal Hydroxide and Its Application as a Chromatographic Stationary PhaseMichael Jakupca and Prabir K. DuttaCite this: Chem. Mater. 1995, 7, 5, 989–994Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 May 1995https://pubs.acs.org/doi/10.1021/cm00053a027https://doi.org/10.1021/cm00053a027research-articleACS PublicationsRequest reuse permissionsArticle Views220Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Heat Exchangers for Cooling Boiler Flue Gas to Temperatures Below the Water Vapor Dewpoint (2011)

Coal-fired power plants have traditionally operated with stack temperatures in the 300°F range to minimize fouling and corrosion problems due to sulfuric acid condensation and to provide a buoyancy force to assist in the transport of flue gas up the stack. However, as an alternative, there would be benefits to cooling the flue gas to temperatures below the water vapor and acid dew points, while capturing the condensed water vapor. This paper describes experimental results from a DOE and industry-funded project to develop condensing heat exchangers for application to coal-fired power plants. A system of condensing heat exchangers was designed, fabricated and tested using slip streams of boiler flue gas and experiments were performed to measure the effects of process parameters on rates of heat transfer and water vapor condensation. In addition, measurements were made to characterize the acid concentrations in the condensed water which collected on the heat exchanger tubes and to quantify the effects of the heat exchangers on flue gas mercury concentrations.
In vivo tomographic imaging of red-shifted fluorescent proteins (2011)

We have developed a spectral inversion method for three-dimensional tomography of far-red and near-infrared fluorescent proteins in animals. The method was developed in particular to address the steep light absorption transition of hemoglobin from the visible to the far-red occurring around 600 nm. Using an orthotopic mouse model of brain tumors expressing the red-shifted fluorescent protein mCherry, we demonstrate significant improvements in imaging accuracy over single-wavelength whole body reconstructions. Furthermore, we show an improvement in sensitivity of at least an order of magnitude over green fluorescent protein (GFP) for whole body imaging. We discuss how additional sensitivity gains are expected with the use of further red-shifted fluorescent proteins and we explain the differences and potential advantages of this approach over two-dimensional planar imaging methods.
Schottky-Drain Technology for AlGaN/GaN High-Electron Mobility Transistors (2010)

In this letter, we demonstrate 27% improvement in the buffer breakdown voltage of AlGaN/GaN high-electron mobility transistors (HEMTs) grown on Si substrate by using a new Schottky-drain contact technology. Schottky-drain AlGaN/GaN HEMTs with a total 2-¿m-thick GaN buffer showed a three-terminal breakdown voltage of more than 700 V, while conventional AlGaN/GaN HEMTs of the same geometry showed a maximum breakdown voltage below 600 V. The improvement of the breakdown voltage has been associated with the planar contact morphology and lack of metal spikes in the Schottky-drain metallization.
Dynamic inductive tuning of Fano-resonant meta-surfaces using plasmonic response of graphene in mid-infrared (2013)

We demonstrate theoretically and experimentally that electrically gated single-layer graphene can be used to inductively tune the infrared optical response of Fano-resonant meta-surfaces. Several implementations will be introduced: graphene of the meta-surface, graphene directly under the meta-surface, and graphene separated by a thin spacer from the meta-surface. Both electrostatic and chemical doping of graphene will be discussed and supporting experimental results presented. Finally, we will demonstrate how the spectral shifts of metamaterials resonances introduced by the graphene can be utilized to extract graphene's electronic properties such as the complex-valued resistivity.
Influences of Indium Fluctuation to carrier transport and the Current-voltage Turn-on Behavior in the InGaN Quantum Well LEDs (2012)

Most commercial c-plane InGaN quantum well (QW) LEDs show an early turn-on voltage, which is significantly lower than the value predicted by numerical simulation even with perfect contacts. To make a more realistic structure for simulations, nano-scale Indium fluctuations were included in the QWs. Simulations of current-voltage (I-V) characteristics using a 2D drift-diffusion solver showed much lower turn-on voltages than models with homogeneous layers and the calculated I-V agreed with experimental value, which may be due to the lateral fluctuations in the potential barrier due to indium fluctuation within the QWs.
Rationale and Design of the CONCERT-HF Trial (Combination of Mesenchymal and c-kit + Cardiac Stem Cells As Regenerative Therapy for Heart Failure) (2018)

URL: http://www.clinicaltrials.gov. Unique identifier: NCT02501811.
First-in-human Study of AZD5153, A Small-molecule Inhibitor of Bromodomain Protein 4, in Patients with Relapsed/Refractory Malignant Solid Tumors and Lymphoma (2023)

AZD5153, a reversible, bivalent inhibitor of the bromodomain and extraterminal family protein BRD4, has preclinical activity in multiple tumors. This first-in-human, phase I study investigated AZD5153 alone or with olaparib in patients with relapsed/refractory solid tumors or lymphoma. Adults with relapsed tumors intolerant of, or refractory to, prior therapies received escalating doses of oral AZD5153 once daily or twice daily continuously (21-day cycles), or AZD5153 once daily/twice daily continuously or intermittently plus olaparib 300 mg twice daily, until disease progression or unacceptable toxicity. Between June 30, 2017 and April 19, 2021, 34 patients received monotherapy and 15 received combination therapy. Dose-limiting toxicities were thrombocytopenia/platelet count decreased (n = 4/n = 2) and diarrhea (n = 1). The recommended phase II doses (RP2D) were AZD5153 30 mg once daily or 15 mg twice daily (monotherapy) and 10 mg once daily (intermittent schedule) with olaparib. With AZD5153 monotherapy, common treatment-emergent adverse events (TEAE) included fatigue (38.2%), thrombocytopenia, and diarrhea (each 32.4%); common grade ≥ 3 TEAEs were thrombocytopenia (14.7%) and anemia (8.8%). With the combination, common TEAEs included nausea (66.7%) and fatigue (53.3%); the most common grade ≥ 3 TEAE was thrombocytopenia (26.7%). AZD5153 had dose-dependent pharmacokinetics, with minimal accumulation, and demonstrated dose-dependent modulation of peripheral biomarkers, including upregulation of HEXIM1. One patient with metastatic pancreatic cancer receiving combination treatment had a partial response lasting 4.2 months. These results show AZD5153 was tolerable as monotherapy and in combination at the RP2Ds; common toxicities were fatigue, hematologic AEs, and gastrointestinal AEs. Strong evidence of peripheral target engagement was observed.
Azacitidine front-line in 339 patients with myelodysplastic syndromes and acute myeloid leukaemia: comparison of French-American-British and World Health Organization classifications (2016)

Our data demonstrate the validity of the WHO classification of MDS and AML, and its superiority over the former FAB classification, for patients treated with azacitidine front-line. Neither bone marrow blast count nor presence of MDS-related features had an adverse prognostic impact on survival. Patients with AML20-30 should therefore be regarded as having 'true AML' and in our opinion treatment should be initiated without delay.
The Defensive Activation Theory: REM Sleep as a Mechanism to Prevent Takeover of the Visual Cortex (2021)

Regions of the brain maintain their territory with continuous activity: if activity slows or stops (e.g., because of blindness), the territory tends to be taken over by its neighbors. A surprise in recent years has been the speed of takeover, which is measurable within an hour. These findings lead us to a new hypothesis on the origin of REM sleep. We hypothesize that the circuitry underlying REM sleep serves to amplify the visual system's activity periodically throughout the night, allowing it to defend its territory against takeover from other senses. We find that measures of plasticity across 25 species of primates correlate positively with the proportion of rapid eye movement (REM) sleep. We further find that plasticity and REM sleep increase in lockstep with evolutionary recency to humans. Finally, our hypothesis is consistent with the decrease in REM sleep and parallel decrease in neuroplasticity with aging.
Osteoarthritis in year 2021: biochemical markers (2021)

Currently, biomarkers research is focused on their use as tools to identify molecular endotypes and clinical phenotypes and to facilitate patient screening and monitoring in clinical trials. This approach should allow a more targeted management of patients suffering from osteoarthritis.
Disposable optical slide provides a snapshot of metabolic parameters from a drop of blood at the bedside (2013)

The metabolic status of critically ill patients in the intensive care unit (ICU) is of critical importance and requires frequent monitoring. Tests done outside of the ICU with slow turnaround may cause undesirable patient outcomes. The numerous disposable test strips required for patient care increase the already high costs of care in the ICU. We have developed a low-cost, reusable optical slide which can provide a metabolic snapshot of a variety of parameters at the point of care from a single drop of blood. The slide incorporates optode-based sensing zones that change color according to the concentrations of the respective analytes. The results can be read by the naked eye, or digitally with an inexpensive reader. Utilizing a single reusable slide for multiple screenings for the same patient makes the device more cost-effective than commercial devices, and improves compliance for disease management. The device is ideally suited for both developed and developing economies. In a pilot clinical trial in the ICU, the performance of the proposed tester compared favorably with parallel results obtained in the central clinical lab.
Enhanced Performance and Flexibility in Silicon Modulators Based on a Coupled-Ring-Resonator Structure (2008)

We propose a high-speed (up to 30 Gb/s) silicon-based coupled-ring modulator that requires small resonance shift and achieves high extinction ratio compared with conventional single ring modulator. Optimized chirp enables reach extension at 1 dB power penalty from 6 to 22 km for 20 Gb/s NRZ data transmission.
Towards an architecture for real-time decision support systems: challenges and solutions (2002)

In large enterprises, huge volumes of data are generated and consumed, and substantial fractions of the data change rapidly. Business managers need up-to-date information to make timely and sound business decisions. Unfortunately, conventional decision support systems do not provide the low latencies needed for decision making in this rapidly changing environment. The paper introduces the notion of real time decision support systems. It distills the requirements of such systems from two real-life IT outsourcing examples drawn from our extensive experience in developing and deploying such systems. We argue that real time decision support systems are complex because they must combine elements of several different types of technologies: enterprise integration real time systems, workflow systems, knowledge management, and data warehousing and data mining. We then describe an approach to addressing these challenges. The approach is based on the message brokering paradigm for enterprise integration, and combines this paradigm with workflow management, knowledge management, and dynamic data warehousing and analysis. We conclude with lessons learnt from building systems based on this architectural approach, and discuss some hard research problems that arise.
Tesseract: Querying Spatial Design Recordings by Manipulating Worlds in Miniature (2023)

New immersive 3D design tools enable the creation of spatial design recordings, capturing collaborative design activities. By reviewing captured spatial design sessions, which include user activities, workflows, and tool use, users can reflect on their own design processes, learn new workflows, and understand others’ design rationale. However, finding interesting moments in design activities can be challenging: they contain multimodal data (such as user motion and logged events) occurring over time which can be difficult to specify when searching, and are typically distributed over many sessions or recordings. We present Tesseract, a Worlds-in-Miniature-based system to expressively query VR spatial design recordings. Tesseract consists of the Search Cube interface acting as a centralized stage-to-search container, and four querying tools for specifying multimodal data to enable users to find interesting moments in past design activities. We studied ten participants who used Tesseract and found support for our miniature-based stage-to-search approach.
High-bandwidth high-power gradient driver for magnetic resonance imaging with digital control (2005)

Gradient coils for magnetic resonance imaging (MRI) require large currents (> 500 A) for the gradient field strength, as well as high voltage (> 1600 V) for fast slew rates. Additionally, extremely high fidelity, reproducing the command signal, is critical for image quality. A new driver topology recently proposed can provide the high power and operate at high switching frequency allowing high bandwidth control. The paper presents additional improvements to the new driver architecture, and more importantly, describes the digital control design and implementation, crucial to achieve the required performance level. The power stage and control have been build and tested with the experimental results showing that the performance achieved with the new digital control capability, more than fulfills the system requirements.
Analysis of Periodic Storage and Reduction of NOx in Catalytic Monoliths (2005)

A one-dimensional two-phase model of an adsorptive catalytic monolith reactor is developed and analyzed. The model simulates the generic features of NOx storage and reduction (NSR), a periodic process involving the sequential trapping on a storage component and conversion of NOx to nitrogen under lean conditions found in the exhaust of lean burn and diesel vehicles. The reactor model includes a phenomenological microkinetic model of NSR on a bifunctional storage catalyst. We examine the effects of several design and operating parameters on the reactant conversion, including cycle timing, feed flowrate, composition, and temperature. The simulations reveal complex spatio-temporal phenomena in the form of traveling concentration and temperature waves. The extent of site blocking by oxygen of NOx adsorption is an important determinant of cyclic enhancement of the NOx conversion. The model predictions are in qualitative agreement with experimental observations reported in the literature. For example, the NOx conversion exhibits a maximum at an intermediate cycle time and increases with decreasing rich pulse duty.
Analysis of carbonaceous biomarkers with the Mars Organic Analyzer microchip capillary electrophoresis system: Aldehydes and ketones (2010)

A microchip CE method is developed for the analysis of two oxidized forms of carbon, aldehydes and ketones, with the Mars Organic Analyzer (MOA). Fluorescent derivitization is achieved in ∼ 15 min by hydrazone formation with Cascade Blue hydrazide in 30 mM borate pH 5-6. The microchip CE separation and analysis method is optimized via separation in 30 mM borate buffer, pH 9.5, at 20°C. A carbonyl standard consisting of ten aldehydes and ketones found in extraterrestrial matter is successfully separated; the resulting LOD depends on the reactivity of the compound and range from 70 pM for formaldehyde to 2 μM for benzophenone. To explore the utility of this method for analyzing complex samples, analyses of several fermented beverages are conducted, identifying ten aldehydes and ketones ranging from 30 nM to 5 mM. A Martian regolith simulant sample, consisting of a basalt matrix spiked with soluble ions and acetone, is designed and analyzed, but acetone is found to have a limited detectable lifetime under simulant Martian conditions. This work establishes the capability of the MOA for studying aldehydes and ketones, a critical class of oxidized organic molecules of interest in planetary and in terrestrial environmental and health studies.
Dataset for: Laser trimming of the operating wavelength of silicon nitride racetrack resonators (2020)

Dataset supports: De Paoli, G et a. (2020). Laser trimming of the operating wavelength of silicon nitride racetrack resonators. Photonics Research.
Resistance to a new catecholic cepbem, BO-1341, in Pseudomonas aeruginosa PAO (1992)

Two distinct types of mutant resistant to the catecholic cephem BO-1341 were isolated spontaneously from Pseudomonas aeruginosa PAO2146: (i) a mutant (CCB5-type) which produced beta-lactamase constitutively, and which appeared to result from a mutation in the regulatory gene (blaI at 41 min) controlling the structural gene (blaP at 25 min); (ii) a mutant (CCB7-type) with specific resistance to BO-1341. Induction of beta-lactamase production in strain CCB7 by BO-1341 was diminished markedly when compared with that in the parent strain. This was not the case for ceftazidime or cefoxitin, suggesting impaired uptake of BO-1341 as an explanation for the resistance. Electrophoretic analysis demonstrated increased production of a 55 kDa protein in the periplasmic space and a 84 kDa outer membrane protein. These data suggested that specific resistance to BO-1341 might involve quantitative alterations in the composition of the outer membrane and periplasmic proteins.
Supplementary Figure 1 from PI3K Inhibition Impairs BRCA1/2 Expression and Sensitizes BRCA-Proficient Triple-Negative Breast Cancer to PARP Inhibition (2023)

&lt;p&gt;PDF file - 195K, PI3K regulates BRCA expression&lt;/p&gt;