gebhart/patrepeval huggingface dataset:
Physical and Pharmacokinetic Characterizations of trans-Resveratrol (t-Rev) Encapsulated with Self-Assembling Lecithin-based Mixed Polymeric Micelles (saLMPMs) (2017)

This study involved physical and pharmacokinetic characterizations of trans-resveratrol (t-Rev)-loaded saLMPMs which attempted to improve t-Rev's pharmacokinetic profiles and bioavailability resolving hurdles limiting its potential health benefits. The optimal formulation consisted of t-Rev, lecithin, and Pluronic<sup>®</sup> P123 at 5:2:20 (t-Rev-loaded PP123 saLMPMs) provided mean particle size <200 nm, encapsulation efficiency >90%, and drug loading >15%. Compared to t-Rev solubilized with HP-β-CD, t-Rev-loaded PP123 saLMPMs enhanced t-Rev's stability in PBS at RT, 4 °C, and 37 °C and in FBS at 37 °C, and retarded the in vitro release. Intravenous administration of t-Rev-loaded PP123 saLMPMs was able to enhance 40% absolute bioavailability and a greater portion of t-Rev was found to preferably distribute into peripheral compartment potentially establishing a therapeutic level at the targeted site. With oral administration, t-Rev-loaded LMPMs increases 2.17-fold absolute bioavailability and furnished a 3-h period of time in which the plasma concentration maintained above the desirable concentration for chemoprevention and accomplished a higher value of the dose-normalized area under the curve for potentially establishing an effective level at the target site. Therefore, intravenous and oral pharmacokinetic characteristics of t-Rev encapsulated with PP123 saLMPMs indicate that t-Rev can be translated into a clinically useful therapeutic agent.
17: Utilization and Outcomes of Intracytoplasmic Sperm Injection for Non-Male Factor Infertility (2006)

You have accessJournal of UrologyDiscussed Poster, Saturday, May 20, 2006, 1:00 - 4:00 pm1 Apr 200617: Utilization and Outcomes of Intracytoplasmic Sperm Injection for Non-Male Factor Infertility Howard H. Kim, M. Kate Bundorf, Barry Behr, and Stewart W. McCallum Howard H. KimHoward H. Kim More articles by this author , M. Kate BundorfM. Kate Bundorf More articles by this author , Barry BehrBarry Behr More articles by this author , and Stewart W. McCallumStewart W. McCallum More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)32284-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "17: Utilization and Outcomes of Intracytoplasmic Sperm Injection for Non-Male Factor Infertility." The Journal of Urology, 175(4S), pp. 6–7 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 6-7 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Howard H. Kim More articles by this author M. Kate Bundorf More articles by this author Barry Behr More articles by this author Stewart W. McCallum More articles by this author Expand All Advertisement Loading ...
Demonstration of mid and long-wavelength infrared antimonide-based focal plane arrays (2009)

We have demonstrated the use of bulk antimonide based materials and type-II antimonide based superlattices in the development of large area mid wavelength infrared (MWIR) focal plane arrays (FPAs) as well as smaller format long wavelength infrared (LWIR) arrays. Barrier infrared photodetectors (BIRDs) and superlattice-based infrared photodetectors are expected to outperform traditional III-V MWIR and LWIR imaging technologies and are expected to offer significant advantages over II-VI material based FPAs. We have used molecular beam epitaxy (MBE) technology to grow InAs/GaSb superlattice pin photodiode and bulk InAsSb structures on GaSb substrates. The coupled quantum well superlattice device offers additional control in wavelength tuning via quantum well sizes and ternary composition. Furthermore, we have fabricated mid-wavelength 1024x1024 pixels superlattice imaging FPAs, 640x512 MWIR arrays based on the BIRD concept, and 256x256 LWIR arrays based on pin superlattice structures. These initial FPA have produced excellent infrared imagery.
Continuous Path Tracking Control by Considering Voltage Saturation and Current Saturation for AC Servo Motor (2009)

Continuous path tracking control is an important technology for the position control system such as factory automation field. Particulaly, large torque is required for continuous path tracking control at its start position and its goal position. Each AC servo motor of continuous path tracking control have limitation of current and voltage. Therefore, in controlling a multi-degree-of-freedom continuous path tracking control system, even if only the motor torque of one axis has the current limitation, the actual position response is not often equal to the desired trajectory reference. In order to overcome these problems, this paper proposes a new continuous path tracking control algorithm by considering both the saturation of voltage and current. The proposed method assures the coordinated motion by considering the saturation of voltage and current. The effectiveness of the proposed method is confirmed by the experimental results in this paper.
Passive Thrust Oscillation Mitigation for the CEV Crew Pallet System (2012)

The Crew Exploration Vehicle (CEV) was intended to be the next-generation human spacecraft for the Constellation Program. The CEV Isolator Strut mechanism was designed to mitigate loads imparted to the CEV crew caused by the Thrust Oscillation (TO) phenomenon of the proposed Ares I Launch Vehicle (LV). The Isolator Strut was also designed to be compatible with Launch Abort (LA) contingencies and landing scenarios. Prototype struts were designed, built, and tested in component, sub-system, and system-level testing. The design of the strut, the results of the tests, and the conclusions and lessons learned from the program will be explored in this paper.
AlGaN channel HEMTs on AlN buffer layer with sufficiently low off-state drain leakage current (2009)

The buffer layer in AlGaN channel HEMTs to suppress the off-state drain leakage current is investigated. By employing an AlN for the buffer layer in Al0.39Ga0.61N/Al0.16Ga0.84N HEMTs, the off-state drain leakage current was sufficiently suppressed and the breakdown voltage was enhanced. It was considered that employing the AlN for the buffer layer is important for extracting the superior material properties of the AlGaN in the channel layer.
Destructive Adsorption of Carbon Tetrachloride on Alkaline Earth Metal Oxides (1998)

The destructive adsorption of CCl4 on MgO, CaO, SrO, and BaO has been studied as a function of the reaction temperature and the amount of CCl4 injected. The reaction was followed using in situ Raman spectroscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, and 13C magic angle spinning nuclear magnetic resonance spectroscopy. It was found that the activity toward CCl4 parallels the basicity of the alkaline earth metal oxide; i.e., the activity decreased in the order BaO > SrO > CaO > MgO. Barium oxide readily reacted with CCl4 at 200−300 °C, and, at these low temperatures, CO2 was the only gas-phase product that evolved from the surface. At higher reaction temperatures, other alkaline earth metal oxides, such as CaO and MgO, also became active, and COCl2 was found to be a reaction intermediate in the destruction of CCl4. Although the destruction process is initiated at the surface, the continuous O2-/Cl- exchange results in the bulk transformation of the metal oxide to the metal chloride. Barium oxide could be regenerated by dissolving the chloride in water, followed by precipitation as barium carbonate and subsequent calcination. In addition, carbon tetrachloride destruction at around 600 °C resulted in the formation of an unusual alkaline earth metal oxide chloride, viz., M4OCl6 (M = Ba, Sr, or Ca).
Nondestructive Investigation of Position Dependent $I_{\rm c}$ Variations in Multi-Meter Coated Conductors (2009)

A coated conductor wire produced by the MOD-RABiTS process was nondestructively characterized for <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> uniformity along its length. Regions of interest were identified by variations in the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> - <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</i> value relationship. These regions were investigated using <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> (B,angle) and <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> (B||c) measurements. It was found that the conductor properties vary from isotropic to anisotropic over a length of a few centimeters. Additionally, the exponent of the power law fit to the field dependence is shown to vary between 0.84 and 0.67. The position dependence of <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> was then measured at two field orientations, <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</i> ||c and <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</i> ||ab, along the conductor in a new two measuring stage system. This system allows rapid characterization of a long conductor while providing easily interpreted data on the source of variations.
Characterizing Relaxation Dynamics in Multi-Chiral Carbon Nanotube Ensembles (2013)

We measured ultrafast relaxation in a deliberately heterogeneous ensemble of carbon nanotubes. Complex differential transmission signatures revealed competition between ground state bleaching and excited state absorption from nanotubes of different chiralities.
Abstract 3604: Targeting the PIM kinases in combination with BTK inhibition is synergistic in preclinical models of B-cell malignancies (2015)

Abstract BTK inhibitors (e.g. ibrutinib) have significantly impacted the treatment of B-cell malignancies in a positive way. Single agent response rates with ibrutinib are 65% or higher in B-cell lymphomas and chronic lymphocytic leukaemia with the majority of patients enjoying a prolonged duration of response. Continued clinical development is needed, however, as most patients achieve only a partial response from their treatment and ultimately patients become refractory to ibrutinib leading to relapse and disease progression. Targeted combinations with ibrutinib could potentially increase the number of patients undergoing complete remission and combat emergent resistant mechanisms. The PIM family (1, 2, and 3) are serine/threonine kinases that have proven to be oncogenic in-part due to their ability to suppress c-Myc induced apoptosis. The PIM kinases have emerged as important regulators of drug resistance in multiple cancer types. Tolero Pharmaceutical's second generation PIM Kinase inhibitor, TP-3654 has exhibited favorable activity in preclinical models of prostate cancer, AML, and lymphoma. Due to the signaling crosstalk between BTK and PIM through the STAT transcription factors, we hypothesized that synergies may arise through the simultaneous targeting of both kinases. Here, we report a significant increase in drug activity when a BTK inhibitor (ibrutinib) was combined with TP-3654 in various lymphoma cell lines. In Granta-519 cells, the IC50 of ibrutinib decreased 3.5-fold, from 0.7 μM to 0.2 μM, when cultured in combination with a subtoxic concentration of TP-3654 (300 nM). Similarly, the IC50 of TP-3654 decreased 6-fold, from 2.4 μM to 0.4 μM, when cells were cultured in combination with a subtoxic concentration of ibrutinib (100 nM). BTK is known to attenuate the activity of the transcription factor STAT3, a major regulator of PIM kinase levels in cells. Due to this, mechanistic studies focused on analyzing the STAT3 pathway are ongoing to determine the downstream effects of using ibrutinib and TP-3654 in combination. Several lymphoma xenograft studies are also ongoing to further explore this combination in vivo. These results provide a strong rationale that inhibitors of PIM and BTK could be used in combination for the treatment of B-cell malignancies and other B-cell mediated diseases. Citation Format: Jeremiah J. Bearss, Brigham L. Bahr, Katie K. Soh, Peter W. Peterson, Clifford J. Whatcott, Adam Siddiqui-Jain, David J. Bearss, Steven L. Warner. Targeting the PIM kinases in combination with BTK inhibition is synergistic in preclinical models of B-cell malignancies. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3604. doi:10.1158/1538-7445.AM2015-3604
Reflectance-Difference Spectroscopy: A New Look At Semiconductor Crystal Growth By MBE And OMCVD (1989)

Reflectance-difference spectroscopy (RDS) is a recently developed normal-incidence optical probe that uses symmetry to enhance the typically low sensitivity of reflectance measurements to surface phenomena. In RDS, the difference between reflectances parallel and perpendicular to the two principal optic axes in the plane of the surface are determined experimentally by modulation techniques. Contributions from the bulk and randomly oriented surface species largely cancel in subtraction, leaving those from the lower-symmetry surface. Sensitivities of 0.01 monolayer to surface species have been demonstrated with averaging times of 100 ms. Being an optical probe, RDS is well suited either to the reactive, relatively high pressure sample environments in organometallic chemical vapor deposition (OMCVD) reactors or to the ultrahigh-vacuum environment of molecular beam epitaxy (MBE) chambers. This allows comparisons of various growth chemistries to be made. Our MBE results for the (001) AlGaAs system show that reflectance-difference (RD) signals respond to either surface chemistry or surface structure depending on photon energy, and can distinguish Al- from Ga-terminated surfaces. Our OMCVD results for the (001) GaAs-trimethylgallium-arsine system follow submonolayer coverage of reacted species and provide the first microscopic information about crystal growth by OMCVD. The time, temperature, and pressure dependences of this coverage show OMCVD growth to be kinetically limited by a combination of reversible excluded-volume chemisorption (at 26 kcal/mole) and subsequent irreversible decomposition (at 39 kcal/mole) of trimethylgallium at surface lattice sites. Further work, especially in combination with a probe such as spectroellipsometry that can detect optically isotropic species, is expected to lead to new understanding of crystal growth and better control of growth processes.
HAXPES Study on Chemical States of Reaction Films Formed on Metal Surfaces by Zinc Dialkyldithiophosphate and Molybdenum Dialkyldithiocarbamate (2022)

The fuel-saving performance of automotive lubricants greatly depends on the composition and chemical structure of the reaction films that form on metal surfaces through chemical reactions between the additives in the lubricant and the metals. In this study, we prepared four kinds of reaction film on metal surfaces using lubricants formulated with ZnDTP only or with ZnDTP and MoDTC and then investigated the relationship between the lubricant formulations and the chain lengths of polyphosphates in the reaction films by angle-resolved HAXPES. The chain lengths of polyphosphates were estimated by the O1s spectra. We found that the polyphosphate chains in the reaction films formed by ZnDTP and MoDTC were shorter than those in the films formed by ZnDTP only, regardless of the length of the ZnDTP’s alkyl group. We also found that films formed by ZnDTP with a shorter alkyl group had longer polyphosphate chains, regardless of whether MoDTC was also present.
Abstract 1280: Inhibition of cellular FLICE-inhibitory protein and induction of Death Receptor 5 expression is a major component of δ- tocotrienol-induced apoptosis in pancreatic cancer cells (2010)

Abstract Background: Previous pre-clinical studies have demonstrated that δ-tocotrienol, is the most bioactive natural vitamin E compound against pancreatic cancer. δ-Tocotrienol induces growth arrest and apoptosis in several human pancreatic cancer cell lines; however, the underlying mechanism remains unknown. In this study, we evaluated the role of the extrinsic and intrinsic apoptotic signaling pathways in δ-tocotrienol-induced apoptosis. Also, we investigated the modulation of cellular FLICE-inhibitory protein (c-FLIP) and death receptor 5 (DR5) by δ-tocotrienol, and the involvement of c-FLIP down-regulation and DR5 up-regulation in δ-tocotrienol-induced apoptosis. Methods: We examined δ-tocotrienol induced apoptosis in human pancreatic cancer cell lines in vitro and in vivo. We used western blot and immunohistochemistry to determine the expression of DR4, DR5, Caspase 8, Caspase 9, Caspase 3, c-FLIP, and PARP. The effect of combination treatment with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and δ-tocotrienol was also determined. We examined the cellular effects of DR5 knockdown using small interfering RNA oligonucleotides, and c-FLIP overexpression using c-FLIP cDNA, on δ-tocotrienol-induced apoptosis using various assays. Results: Delta-tocotrienol activated caspase-8 and its downstream caspases but not caspase-9. Caspase-8 specific inhibitor abrogated δ-tocotrienol-induced apoptosis whereas caspase-9 specific inhibitor did not, indicating that δ-tocotrienol induces caspase-8 -dependent apoptosis. c-FLIP was rapidly down-regulated by δ-tocotrienol in all of the tested cell lines. Delta-tocotrienol up-regulated DR4 and DR5 significantly and enhanced TRAIL-induced apoptosis. Enforced expression of ectopic c-FLIP, and DR5 knockdown partially abolished δ-tocotrienol-induced apoptosis. δ-Tocotrienol inhibition of pancreatic tumor growth in SCID mice was associated with significant induction of apoptosis, activation of caspase 8, and down-regulation of c-FLIP expression. Conclusion: We conclude that DR5 up-regulation and c-FLIP down-regulation contributes to δ-tocotrienol-induced apoptosis in pancreatic cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1280.
Electrochemically Active Soluble Mediators from Shewanella oneidensis: Relevance to Microbial Fuel Cells and Extracellular Electron Transfer (2008)

Abstract not Available.
Modeling and characterization of the IGBT electrothermal transistor for circuit applications (2002)

An analytical model for the power Insulated Gate Bipolar Transistor (IGBT) including electrothermal interactions is developed. In this model the device's temperature becomes an interactive variable during the simulation. The model has been implemented in the Saber circuit simulator. Comparisons between simulation and measurement show that the steady-state as well as the transient analysis of the IGBT are accurately reproduced.
Human T-Cell Leukemia Virus Type I Tax Associates with and Is Negatively Regulated by the NF-κB2 p100 Gene Product: Implications for Viral Latency (1994)

Human T-cell leukemia virus type I (HTLV-I) is the etiologic agent of the adult T-cell leukemia, an aggressive and often fatal malignancy of activated human CD4 T cells. HTLV-I encodes an essential 40-kDa protein termed Tax that not only transactivates the long terminal repeat of this retrovirus but also induces an array of cellular genes. Tax-mediated transformation of T cells likely involves the deregulated expression of various cellular genes that normally regulate lymphocyte growth produced by altered activity of various endogenous host transcription factors. In particular, Tax is capable of modulating the expression or activity of various host transcription factors, including members of the NF-kappa B/Rel and CREB/ATF families, as well as the cellular factors HEB-1 and p67SRF. An additional distinguishing characteristic of HTLV-I infection is the profound state of viral latency that is present in circulating primary leukemic T cells. In this study, we demonstrate that HTLV-I Tax can physically associate with p100, the product of the Rel-related NF-kappa B2 gene, both in transfected cells and in HTLV-I-infected leukemic T-cell lines. Furthermore, the physical interaction of Tax with p100 leads to the inhibition of Tax-induced activation of the HTLV-I and human immunodeficiency virus type 1 long terminal repeats, reflecting p100-mediated cytoplasmic sequestration of the normally nuclearly expressed Tax protein. In contrast, a mutant of Tax that selectively fails to activate nuclear NF-kappa B expression does not associate with p100. Together, these results suggest that the cytoplasmic interplay of Tax and p100 may play an important role in the initiation and maintenance of HTLV-1 latency observed in adult T-cell leukemia.
A Study on Active Noise Control in 3-Dimensional Space. Active Acoustic Power Control Using Acoustic Nodal Points. (1995)

An active acoustic power control method for three-dimensional space was investigated both theoretically and experimentally. This paper focuses on the typical case of a single primary and multiple secondary point sources, and methods of minimizing the power output using the exisiting Filtered-X LMS algorithm are presented. Suitable arrangements of the sources and microphone are proposed on the basis of theoretical estimations. The authors call this the acoustic nodal point method. The power reducing performance was verified by applying the method to the noise radiating from a duct opening. Considerable noise reduction was achieved both at the error microphone and in the whole area around the noise source.