gebhart/patrepeval huggingface dataset:
LytM Proteins Play a Crucial Role in Cell Separation, Outer Membrane Composition, and Pathogenesis in Nontypeable Haemophilus influenzae (2015)

Nontypeable Haemophilus influenzae (NTHI) is an opportunistic pathogen that colonizes the human nasopharynx and can cause serious infections in children (acute otitis media) and adults (chronic obstructive pulmonary disease). Several virulence factors are well studied, but the complete scenario of NTHI pathogenesis is still unclear. We identified and characterized three NTHI LytM factors homologous to the Escherichia coli LytM proteins. Although LytM factors are reported to play a crucial role in the cell division process, in NTHI they are also involved in other bacterial functions. In particular, YebA and NlpD are fundamental for membrane stability: indeed, their absence causes an increased release of outer membrane vesicles (OMVs). On the other hand, our data suggest that EnvC could directly or indirectly affect peptidoglycan permeability and consequently, bacterial periplasmic and outer membrane protein distribution. Interestingly, by modulating the surface composition of virulence determinants, EnvC also has an impact on NTHI pathogenesis.
Fracture Toughness of Chemically Vapor‐Deposited Diamond (1991)

The fracture toughness of chemically vapor‐deposited diamond is estimated by a Vickers indentation method. Freestanding diamond films of 400‐μm thickness are produced with plasma‐enhanced chemical vapor deposition and highly polished for indentation testing. Indentation testing was performed with a microhardness tester using a load range of 5 to 8 N. The average fracture toughness is estimated as 5.3 ± 1.3 MPA · m 1/2 .
ChemInform Abstract: Investigation of Porphyrin‐Forming Reactions. Part 4. Examination of the Reaction Course in Syntheses of Porphyrins via Dipyrromethanecarbinols. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Network lifetime maximization via cooperation (2008)

Extending the lifetime of battery-operated devices is a key design issue that allows uninterrupted information exchange among distributed nodes in wireless networks. Cooperative communications enables and leverages effective resource sharing among cooperative nodes. This chapter provides a general framework for lifetime extension of battery-operated devices by exploiting cooperative diversity. The framework efficiently takes advantage of different locations and energy levels among distributed nodes. First, a lifetime maximization problem via cooperative nodes is considered and performance analysis for M-ary PSK modulation is provided. With an objective to maximize the minimum device lifetime under a constraint on bit error rate performance, the optimization problem determines which nodes should cooperate and how much power should be allocated for cooperation. Moreover, the device lifetime is further improved by a deployment of cooperative relays in order to help forward information of the distributed nodes in the network. Optimum location and power allocation for each cooperative relay are determined with an aim to maximize the minimum device lifetime. A suboptimal algorithm is presented to solve the problem with multiple cooperative relays and cooperative nodes.
OP23 Efficacy and safety of vedolizumab SC in patients with moderately to severely active Crohn’s disease: Results of the VISIBLE 2 study (2020)

Abstract Background Vedolizumab (VDZ) is a gut-selective, humanised, monoclonal α 4β 7 integrin antibody for the treatment of patients with moderately to severely active ulcerative colitis (UC) or Crohn’s disease (CD). VDZ is currently an intravenous (IV) therapy; a subcutaneous (SC) formulation is under development to provide patients with an alternative route of administration for maintenance treatment for UC and CD. Here we present the first data from the phase 3 study of VDZ SC maintenance treatment in CD. Methods VISIBLE 2 (NCT02611817; EudraCT 2015-000481-58) was a randomised, double-blind, placebo (PBO)-controlled phase 3 trial of VDZ SC as maintenance treatment in adults with moderately to severely active CD. Patients (n = 644) received open-label VDZ 300mg IV induction therapy at Weeks 0 and 2. At Week 6, clinical responders (defined as patients with a ≥70-point decrease in CD Activity Index [CDAI] from baseline) were randomly assigned to receive vedolizumab SC (108 mg every 2 weeks [Q2W]), or placebo (Q2W) for up to 52 weeks. The primary endpoint was clinical remission at Week 52 (defined as CDAI score ≤150). Rank-ordered secondary endpoints were enhanced clinical response at Week 52 (a drop of ≥100 in CDAI score), corticosteroid (CS)-free clinical remission at Week 52, and clinical remission at Week 52 in anti-tumour necrosis factor (TNF)-naïve patients. Finally, VDZ immunogenicity and predefined adverse events of special interest were assessed. Results Patients who responded to VDZ IV induction at Week 6 (n = 409) were randomised to VDZ SC (n = 275) or PBO (n = 134) maintenance and received at least 1 dose of study drug; 61% and 53%, respectively, were previously exposed to anti-TNF therapy. At Week 52, 48.0% of patients on VDZ SC vs. 34.3% on PBO were in clinical remission (p = 0.008, Figure). Enhanced clinical response at Week 52 was reached by 52.0% vs. 44.8% of patients on VDZ SC vs. PBO, respectively (p = 0.167). Among patients on concomitant CS at baseline (VDZ SC, n = 95; PBO, n = 44), 45.3% receiving VDZ SC vs. 18.2% receiving PBO achieved CS-free clinical remission at Week 52. Of anti-TNF-naïve patients (VDZ SC, n = 107; PBO, n = 63), 48.6% vs. 42.9% were in clinical remission at Week 52 in the VDZ SC and PBO arms, respectively. Injection-site reactions were reported for &amp;lt;3% of patients treated with VDZ SC. Serious infections, malignancy, and liver injury were ≤5% for both arms. Anti-VDZ antibodies were detected in 7 (2.5%) patients treated with VDZ SC arm; 4 of 7 patients developed neutralising antibodies. No new safety signals were observed. Conclusion Among VDZ IV induction responders, significantly more patients on maintenance VDZ SC than PBO achieved clinical remission at Week 52. The safety findings with VDZ SC remain in line with the known safety profile of VDZ IV in patients with CD.
The spore photoproduct lyase repairs the 5S- and not the 5R-configured spore photoproduct DNA lesion (2005)

The spore photoproduct lyase is a Fe-S/AdoMet DNA repair enzyme, which directly repairs spore lesions, induced by UV irradiation of spores, using an unknown radical mechanism. The air sensitive radical SAM enzyme was for the first time challenged with synthetically pure substrates. It was found that the enzyme recognizes a synthetic 5S-configured spore lesion without the central phosphodiester bond. The 5R-configured lesion is in contrast to current belief not a substrate.
ChemInform Abstract: Chemoenzymatic Synthesis of (‐)‐Carbovir Utilizing a Whole Cell‐ Catalyzed Resolution of 2‐Azabicyclo(2.2.1)hept‐5‐en‐3‐one. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Pulsatile pipe flow transition: Flow waveform effects (2018)

Although transition is known to exist in various hemodynamic environments, the mechanisms that govern this flow regime and their subsequent effects on biological parameters are not well understood. Previous studies have investigated transition in pulsatile pipe flow using non-physiological sinusoidal waveforms at various Womersley numbers but have produced conflicting results, and multiple input waveform shapes have yet to be explored. In this work, we investigate the effect of the input pulsatile waveform shape on the mechanisms that drive the onset and development of transition using particle image velocimetry, three pulsatile waveforms, and six mean Reynolds numbers. The turbulent kinetic energy budget including dissipation rate, production, and pressure diffusion was computed. The results show that the waveform with a longer deceleration phase duration induced the earliest onset of transition, while the waveform with a longer acceleration period delayed the onset of transition. In accord with the findings of prior studies, for all test cases, turbulence was observed to be produced at the wall and either dissipated or redistributed into the core flow by pressure waves, depending on the mean Reynolds number. Turbulent production increased with increasing temporal velocity gradients until an asymptotic limit was reached. The turbulence dissipation rate was shown to be independent of mean Reynolds number, but a relationship between the temporal gradients of the input velocity waveform and the rate of turbulence dissipation was found. In general, these results demonstrated that the shape of the input pulsatile waveform directly affected the onset and development of transition.
Characterization of a novel pesticide transporter and P-glycoprotein orthologues in Drosophila melanogaster (2022)

Pesticides remain one of the most effective ways of controlling agricultural and public health insects, but much is still unknown regarding how these compounds reach their targets. Specifically, the role of ABC transporters in pesticide absorption and excretion is poorly understood, especially compared to the detailed knowledge about mammalian systems. Here, we present a comprehensive characterization of pesticide transporters in the model insect <i>Drosophila melanogaster</i>. An RNAi screen was performed, which knocked down individual ABCs in specific epithelial tissues and examined the subsequent changes in sensitivity to the pesticides spinosad and fipronil. This implicated a novel ABC drug transporter, <i>CG4562,</i> in spinosad transport, but also highlighted the P-glycoprotein orthologue <i>Mdr65</i> as the most impactful ABC in terms of chemoprotection. Further characterization of the P-glycoprotein family was performed via transgenic overexpression and immunolocalization, finding that <i>Mdr49</i> and <i>Mdr50</i> play enigmatic roles in pesticide toxicology perhaps determined by their different subcellular localizations within the midgut. Lastly, transgenic <i>Drosophila</i> lines expressing P-glycoprotein from the major malaria vector <i>Anopheles gambiae</i> were used to establish a system for <i>in vivo</i> characterization of this transporter in non-model insects. This study provides the basis for establishing <i>Drosophila</i> as a model for toxicology research on drug transporters.
Spontaneous Emission Enhancement in Pillar-Type Microcavities (1993)

A reduction in photoluminescence decay time of pillar-type microcavities was observed with decreasing the detuning between the resonance wavelength of the cavities and the luminescence peak wavelength of the active layers. The radiative recombination time was extracted from the measured photoluminescence decay time by a diffusion equation analysis. The obtained spontaneous emission enhancement factor was between 1.6 and 1.8. This is the first observation of a spontaneous emission enhancement in three-dimensionally confined semiconductor microcavities.
Coordinated Scheduling And Beamforming For Multicell Spectrum Sharing Networks Using Branch &Amp; Bound (2012)

Publication in the conference proceedings of EUSIPCO, Bucharest, Romania, 2012
Material Selection for Heavy Liquid Fuel-Fired Supercritical Boilers (2015)

Abstract Material selection for waterwall and superheater/reheater tubing for a heavy liquid fuel-fired supercritical boiler was performed based on hot corrosion testing. This was carried out at varying temperatures through simulated firing conditions using heavy liquid fuel on bare carbon steel UNS K02599, low-alloyed steel UNS K11562, carbon steel with UNS N06022 weld overlay, and carbon steel with 50Cr-50Ni thermal spray coating for waterwall tubing; and on austenitic stainless steels UNS S34709, UNS S30432, UNS S31042, Ni-based alloys UNS N06617, Alloy 740, Ni-Cr-Fe alloys UNS S35045 and UNS N08810 for superheater/reheater tubing. Mg-based fuel additive, an inhibitor of hot corrosion, was also used in testing the superheater/reheater tubing. The results showed that carbon steel with UNS N06022 overlay and austenitic stainless steel UNS S31042 yielded the best performance for waterwall tubing and superheater/reheater tubing, respectively. The application of a Mg-based fuel additive also showed great merit in suppressing corrosion in the superheater and reheater sections. This test program constitutes part of a feasibility study for the design and construction of supercritical boilers to enhance power generation in the Kingdom.
The Metastatic Prostate Cancer project (MPCproject): Translational genomics through direct patient engagement. (2018)

279 Background: While there has been substantial advancement in the genomic understanding of metastatic prostate cancer (MPC), there is still much to be discovered. Additional progress is dependent upon obtaining a large amount of clinically-annotated genomic data. Therefore, we piloted a direct-to-patient nationwide research initiative where patients can contribute their medical records and biospecimens to accelerate research ( mpcproject.org ). Methods: In collaboration with patients and advocacy groups, we have developed a website ( mpcproject.org ). Participants are asked to complete a 17-question survey about their experiences with prostate cancer and an electronic informed consent. All participants receive a saliva kit for germline DNA and blood kit for circulating tumor DNA (ctDNA). Additionally, medical records are collected and archived tissue samples are requested if available. Ultra low pass whole genome sequencing (ULP-WGS) and whole exome sequencing (WES) are performed on the whole blood samples. WES is performed on saliva samples. Genomic, clinical, and patient-reported data will be shared widely with the research community. Aggregate study results will be reported to patients. Results: As of October 2017, 12 pilot patients aged 47-74 from 7 states, provided informed consent. 7 saliva kits, 4 blood kits, and 2 medical records were received. 4 patients were diagnosed with de novo metastatic disease, 8 reported a family history of breast and/or prostate cancer, 6 reported a secondary malignancy. All blood kits were submitted for ULP-WGS and WES. Updated genomic, clinical, and patient-reported data will be presented. Conclusions: We have provided preliminary evidence that partnering directly with MPC patients enabled the remote collection of saliva and blood samples, medical records, and patient-reported data. At the conclusion of the pilot phase, the MPC Project will open enrollment for all men with metastatic and advanced prostate cancer in the US and Canada.
Local Dispersion Map Deviations in Metro-Regional Transmission Investigated Using a Dynamically Re-Configurable Re-Circulating Loop (2007)

The performance of 40x10.7 Gb/s NRZ-OOK signals is measured in a dynamically reconfigurable recirculating loop experiment with local dispersion map variations up to +/-120 ps/nm and mean residual-dispersion per-span between 10.3-54.0 ps/nm over 28x27dB spans.
Murine myeloid cell MCPIP1 suppresses autoimmunity by regulating B-cell expansion and differentiation (2021)

Myeloid-derived cells, in particular macrophages, are increasingly recognized as critical regulators of the balance of immunity and tolerance. However, whether they initiate autoimmune disease or perpetuate disease progression in terms of epiphenomena remains undefined.Here, we show that depletion of MCPIP1 in macrophages and granulocytes (<i>Mcpip1<sup>fl/fl</sup>-LysM<sup>cre+</sup></i> C57BL/6 mice) is sufficient to trigger severe autoimmune disease. This was evidenced by the expansion of B cells and plasma cells and spontaneous production of autoantibodies, including anti-dsDNA, anti-Smith and anti-histone antibodies. Consequently, we document evidence of severe skin inflammation, pneumonitis and histopathologic evidence of glomerular IgG deposits alongside mesangioproliferative nephritis in 6-month-old mice. These phenomena are related to systemic autoinflammation, which secondarily induces a set of cytokines such as <i>Baff</i>, <i>Il5</i>, <i>Il9</i> and <i>Cd40L</i>, affecting adaptive immune responses. Therefore, abnormal macrophage activation is a key factor involved in the loss of immune tolerance.Overall, we demonstrate that deficiency of MCPIP1 solely in myeloid cells triggers systemic lupus-like autoimmunity and that the control of myeloid cell activation is a crucial checkpoint in the development of systemic autoimmunity.
Kansas State University's Autonomous Robot Borivoj: An Entry in the AAAI2002's Robot Host Competition. (2002)

A robust competitor was developed using simple approaches on an Activmedia Pioneer robot using sonars and an infrared sensor. Simple techniques were developed to sense people, serve food, sense an empty food tray, and to locate the food refilling station. Simple voice recognition and text-to-speech tools were used.
Potassium Phosphate Catalyzed Nitroaldol Reaction. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Tumors of the Stomach (2008)

This chapter contains sections titled: Gastric adenocarcinoma Other gastric tumors References
Solvent Free Synthesis of PdZn/TiO2 Catalysts for the Hydrogenation of CO2 to Methanol (2018)

Catalytic upgrading of CO<sub>2</sub> to value-added chemicals is an important challenge within the chemical sciences. Of particular interest are catalysts which are both active and selective for the hydrogenation of CO<sub>2</sub> to methanol. PdZn alloy nanoparticles supported on TiO<sub>2</sub> via a solvent-free chemical vapour impregnation method are shown to be effective for this reaction. This synthesis technique is shown to minimise surface contaminants, which are detrimental to catalyst activity. The effect of reductive heat treatments on both structural properties of PdZn/TiO<sub>2</sub> catalysts and rates of catalytic CO<sub>2</sub> hydrogenation are investigated. PdZn nanoparticles formed upon reduction showed high stability towards particle sintering at high reduction temperature with average diameter of 3-6 nm to give 1710 mmol kg<sup>-1</sup> h of methanol. Reductive treatment at high temperature results in the formation of ZnTiO<sub>3</sub> as well as PdZn, and gives the highest methanol yield.
Predominant Expression of an Arachidonate Epoxygenase in Islets of Langerhans Cells in Human and Rat Pancreas (1997)

Our laboratory recently described a new human cytochrome P450 arachidonic acid epoxygenase (CYP2J2) and the corresponding rat homolog (CYP2J3). Immunoblotting studies using a polyclonal antibody raised against recombinant human CYP2J2 confirmed CYP2J protein expression in human and rat pancreatic tissues. Immunohistochemical staining of formalin-fixed paraffin-embedded rat and human pancreas using the anti-CYP2J2 IgG and avidin-biotin-peroxidase detection revealed that CYP2J protein expression was highly localized to cells in the islets of Langerhans, with minimal staining in pancreatic exocrine cells. Colocalization studies using antibodies to the glucagon, insulin, somatostatin, and pancreatic polypeptide as markers for α-, β-,δ -, and PP cells, respectively, showed that CYP2J protein expression was abundantly present in all four cell types, but was highest in the glucagon-producing α-cells. Direct evidence for the epoxidation of arachidonic acid by pancreatic cytochrome P450 was provided by documenting, for the first time, the presence of epoxyeicosatrienoic acids in vivo in human and rat pancreas by gas chromatography/mass spectrometry. Importantly, the levels of immunoreactive CYP2J2 in different human pancreatic tissues were highly correlated with endogenous epoxyeicosatrienoic acid concentrations. We conclude that human and rat pancreas contain an arachidonic acid epoxygenase belonging to the CYP2J subfamily that is highly localized to islet cells. These data together with previous work showing effects of epoxyeicosatrienoic acids in stimulating insulin and glucagon secretion from isolated rat pancreatic islets support the hypothesis that epoxygenase products may be involved in stimulus-secretion coupling in the pancreas.
Potential Role of Hepatocyte Growth Factor, a Novel Angiogenic Growth Factor, in Peripheral Arterial Disease : Downregulation of HGF in Response to Hypoxia in Vascular Cells (1999)

Although hepatocyte growth factor (HGF), a novel angiogenic growth factor, plays an important role in angiogenesis, regulation of local HGF production under hypoxia has not yet been clarified in vascular smooth muscle cells (VSMC) and endothelial cells (EC). Thus, we have studied the role of HGF in hypoxia-induced endothelial injury and the regulation of local vascular HGF expression in response to hypoxia.
Estimation of character diagram from open-movie databases for cultural understanding (2015)

In many movies, cultures, social conditions, and awareness of the issues of the times are depicted in any form. Even if fantasy and SF are works far from reality, the stories do mirror the real world. Therefore, we assumed to be able to understand social conditions and cultures of the real world by analyzing the movie. As a way to analyze the film, we decided to estimate the interpersonal relationships between the characters in the movies. In this paper, we propose a method of estimating interpersonal relationships of the characters using Markov Logic Network from movie script databases on the Web. Markov Logic Network is a probabilistic logic network that can describe the relationships between characters, which are not necessarily satisfied on every occasion. In experiments, we confirmed that our proposed method can estimate favors between the characters in a movie with a precision of 64.2%. Finally, by comparing the estimated relationships with social indicators, we discussed the relevance of the movie to the real world.