gebhart/patrepeval huggingface dataset:
Psychiatric risk gene NT5C2 regulates protein translation in human neural progenitor cells (2018)

Abstract Genome-wide significant variants associated with combined risk for major psychiatric disorders on chromosome 10q24 affect the expression of the cytosolic 5’-nucleotidase II ( NT5C2, cN-II ) in population controls, implicating it as a psychiatric susceptibility gene. Risk alleles are associated with reduced expression of this gene in the developing and adult brain, but the resulting neurobiological risk mechanisms remain elusive. In this study, we provide further evidence for the association of NT5C2 with psychiatric disorders, and use a functional genetics approach to gain a deeper understanding of the function of this risk gene in the nervous system. NT5C2 expression was significantly reduced in the post-mortem brain of schizophrenia and bipolar disorder patients, and its protein predominately expressed in neurons within the adult brain. Using human neural progenitor cells (hNPCs), we found that NT5C2 expression peaked at the neural progenitor state, where the encoded protein was ubiquitously distributed through the cell. NT5C2 knockdown in hNPCs elicited transcriptomic changes associated with protein translation, that were accompanied by regulation of adenosine monophosphate-activated protein kinase (AMPK) signalling and ribosomal protein S6 (rpS6) activity. To identify the effect of reduced neuronal NT5C2 expression at a systems level, we knockdown its homologue, CG32549 , in Drosophila melanogaster CNS. This elicited impaired climbing behaviour in the model organism. Collectively, our data implicate NT5C2 expression in risk for psychiatric disorders and in Drosophila melanogaster motility, and further suggest that risk is mediated via regulation of AMPK signalling and protein translation during early neurodevelopment.
Optimizing variable DC link voltage for an induction motor drive under dynamic conditions (2015)

Induction motor drives are conventionally operated with a fixed inverter dc-link bus voltage. However, low drive speeds will result in low modulation index and poor dc bus utilization of the inverter. Aperiodic current controllers, such as hysteresis controllers, exhibit increased switching frequencies and losses for higher dc-link voltages. These high switching frequencies can be avoided by dynamically varying the dc-link voltage according to drive operating conditions. In addition to reducing inverter switching losses, varying the dc-link voltage also reduces the switched voltage magnitude across inverter semiconductor switches, potentially increasing inverter reliability. In the proposed work, the link voltage is varied by using a front-end dc-dc buck converter. The link voltage command is derived using a loss minimization technique that uses flux and rotor speed commands to the drive. The effect of additional loss from the front-end converter on the total loss is also investigated. Simulation and experimental results indicate that a variable dc-link voltage supports substantial power electronics loss reduction in applications with highly varying speed conditions.
Development of Innovative Mechanical Flexible Solar Array Architecture (2017)

Flexible solar array architecture is proposed instead of rigid one, for high power solar array used from space tug mission to GEO satellite one, but also for specific scientific mission. THALES ALENIA SPACE has developed with Centre National d’Etudes Spatiales (CNES) support, innovative mechanical flexible solar array architecture, using 22 m long carbon tape-springs.
Wavefront orientation effects on bipolar epicardial electrograms (2002)

It is determined whether information about wavefront orientation could be extracted from electrograms recorded from bipolar electrodes with poles 2 mm apart. Wavefront orientation was measured by using the line connecting the poles of each bipolar electrode as one side of the angle and the tangent to the approaching wavefront at the center of the electrode pair as the other side. Electrograms recorded from sites with small angle wavefront orientation (0 degrees <or=angle<or=30 degrees ) had significantly lower (p<or=0.0002, Wilcoxon rank sums test) peak-to-peak amplitudes, maximum amplitudes, and maximum slopes than did electrograms recorded from sites with large angle wavefront orientations (60 degrees <or=angle<or=90 degrees ). Electrograms were also classified by shape into groups having 0, 1, 2, or 3 peaks with most electrograms characterized by a single peak (78% for large angle electrograms versus 57% for small angle ones). There were significant differences between the small and large angle groups given the shapes of the electrograms with the most significant differences occurring for electrograms with a single peak.<<ETX>>
P.008 Alzheimer’s disease biomarker testing from the perspective of patients and caregivers (2023)

Background: To enrich our understanding of the impact of Alzheimer’s disease (AD) CSF biomarker testing on patients and caregivers, we examined these perspectives within the IMPACT-AD BC study. Methods: IMPACT-AD BC (NCT05002699, impactAD.org) is an observational, longitudinal study examining the impact of AD CSF biomarker testing (i.e., amyloid-beta and tau proteoforms) on personal and medical utility, and health economics. Patients underwent AD biomarker testing as part of medical care (n=142), and for the personal utility arm, a subset of patients (n=34), and their ‘care partner’ (n=31), were interviewed post-biomarker disclosure to understand their decision-making to undergo testing and the impact of learning the test results. Results: The primary consideration in patients’ decision to undergo testing was the desire for diagnostic clarity (63%). After biomarker result disclosure, patients’ positive feelings stemmed largely from having greater diagnostic certainty (55%) and the ability to plan for the future (23%), including making financial changes (58%) and care plans (21%). Care partners conveyed that biomarker testing provided needed information to help plan for the future and spurred them to connect with community resources. Conclusions: Patients and care partners value the diagnostic clarity from AD biomarker testing and use the information to make informed future plans.
Supplementary Figures 1-3 from Taxol Increases the Amount and T Cell–Activating Ability of Self-Immune Stimulatory Multimolecular Complexes Found in Ovarian Cancer Cells (2023)

Supplementary Figures 1-3 from Taxol Increases the Amount and T Cell–Activating Ability of Self-Immune Stimulatory Multimolecular Complexes Found in Ovarian Cancer Cells
Bovine Pancreatic Ribonuclease: Fifty Years of the First Enzymatic Reaction Mechanism (2011)

Fifty years ago, the group of Tony Mathias and Bob Rabin at University College London deduced the first mechanism for catalysis by an enzyme, ribonuclease [Findlay, D., Herries, D. G., Mathias, A. P., Rabin, B. R., and Ross, C. A. (1961) Nature 190, 781-784]. Here, we celebrate this historic accomplishment by surveying knowledge of enzymology and protein science at that time, facts that led to the formulation of the mechanism, criticisms and alternative mechanisms, data that supported the proposed mechanism, and some of the refinements that have since provided a more precise picture of catalysis of RNA cleavage by ribonucleases. The Mathias and Rabin mechanism has appeared in numerous textbooks, monographs, and reviews and continues to have a profound impact on biochemistry.
Pre-clinical characterization of an HBsAg-specific monoclonal antibody preventing HBV spreading and reducing HBV, HDV and HBsAg in serum of humanized mice (2022)

Treatment using monoclonal antibodies targeting the HBV surface proteins has the potential to induce functional cure not only in chronic HBV (CHB) patients but also in individuals coinfected with HDV, which depends on HBsAg for its life cycle. HBC34, the parental molecule of VIR-3434, is a human monoclonal antibody targeting the antigenic loop present in all HBV surface proteins (L-/M-/S-HBsAg). VIR-3434 is currently in Phase 1/2 clinical development.
A Once-Through Fuel Cycle for Fast Reactors (2009)

A paradigm shift has recently altered the design targets for advanced nuclear energy systems that use a fast neutron spectrum. A previous emphasis on extending fissile fuel reserves has been supplanted by a desire for reactor technologies that are “cleaner, more efficient, less waste-intensive, and more proliferation-resistant.” [1] This shift, along with recent advances in fast-reactor designs that enable high fuel burn-up even with fuels that have been minimally enriched, creates an opportunity to employ fast reactors in an open nuclear fuel cycle. These goals now appear feasible as a result of recent design work exploiting a phenomenon, known as a traveling wave, that can attain high burn-ups without reprocessing. A traveling-wave reactor (TWR) breeds and uses its own fuel in place as it operates. Fueled almost entirely by depleted or natural uranium, such reactors would also require little initial enrichment. We have performed calculations demonstrating that TWRs can achieve burn-ups of ≥20%, which is four to five times that realized in current LWRs. Burn-ups of up to 50% appear feasible. The factors that contribute to these high burn-ups and the implications for materials design will be discussed.
3GPP NB-IOT Coverage Extension Using LEO Satellites (2018)

Machine-Type Communications are meeting a growing interest on the consumer market. Dedicated technologies arise to support more robust communications involving a massive number of low cost, low energy-consuming devices. This paper discusses the coverage extension of a Low-Powered Wide Area Network using a Low Earth Orbit satellite constellation, benefiting from the improved performance of a recent standard. The transmission complies with the user equipment specifications standardized as NB-IoT by 3GPP in Release 13. This radio technology is an update on LTE standard with enhanced performances: the supported path loss can be 20 dB higher than with legacy LTE. This improvement makes satellite- compatible the small and energy-constrained devices. A specific unidirectional system is defined, and a link budget is derived. Also, a receiver architecture is presented, that takes into consideration satellite channel specific impairments.
In-situContamination Thickness Measurement by Novel Resist Evaluation System at NewSUBARU (2011)

To reduce the influence of carbon contamination growth, which is the origin of the resist outgassing during extreme ultraviolet (EUV) exposure, it is necessary to study the relationship between the outgassing species from the resist and carbon contamination growth during EUV exposure. Thus a novel evaluation system which enable the measurement of the carbon contamination thickness on a Mo/Si multilayer witness sample by in-situ ellipsometry in the resist outgassing environment under EUV exposure was installed at the beamline in the NewSUBARU synchrotron radiation facility. The carbon contamination thickness on the witness sample measured by in-situ ellipsometry is in good agreement with those measured using an atomic microscope and by reflectivity measurement. In addition, it is found that the time dependence of the carbon growth on a witness sample is due to the difference in outgassing species from the resist samples during EUV exposure. Furthermore, for the model resist of poly(hydroxystyrene) containing the protectiive group of tertial butoxycarbonyl group with a photoacid generator (PAG) and a quencher, the time dependence of contamination thickness was mainly due to the decomposition of outgassing species of the tert-butoxycarbonyl group and the residual casting solvent, such as propyleneglycol monomethyl ether acetate. In order to evaluate the carbon contamination thickness measurement, the in-situ measurement system was moved to the 10.8-m-long undulator beamline. The EUV light intensity flux was estimated to be the same level as that required in high-volume manufacturing.
Millimeterwave Imaging Sensor Nets: A Scalable 60-GHz Wireless Sensor Network (2007)

We report first experimental results on the prototype for a novel wireless sensor network that offers both data collection and localization capability. The proposed architecture assumes minimal sensor functionality in analogy to optical imaging, and suits very large-scale sensor networks. The use of millimeterwave beacon, wide in frequency and narrow in space, enables accurate flight-time (and thus distance) and angular location measurement with the employment of noncoherent 2-D matched filtering. Design and characterization of a 60-GHz prototype system, including low-cost passive sensor, is presented.
Cyclic Failure Mechanisms of Thermal and Environmental Barrier Coating Systems Under Thermal Gradient Test Conditions (2002)

Plasma-sprayed ZrO2-8wt%Y2O3 and mullite+BSAS/Si multilayer thermal and environmental barrier coating (TBC-EBC) systems on SiC/SiC ceramic matrix composite (CMC) substrates were thermally cyclic tested under high thermal gradients using a laser high-heat-flux rig in conjunction with furnace exposure in water-vapor environments. Coating sintering and interface damage were assessed by monitoring the real-time thermal conductivity changes during the laser heat-flux tests and by examining the microstructural changes after exposure. Sintering kinetics of the coating systems were also independently characterized using a dilatometer. It was found that the coating failure involved both the time-temperature dependent sintering and the cycle frequency dependent cyclic fatigue processes. The water vapor environments not only facilitated the initial coating conductivity increases due to enhanced sintering and interface reaction, but also promoted later conductivity reductions due to the accelerated coating cracking and delamination. The failure mechanisms of the coating systems are also discussed based on the cyclic test results and are correlated to the sintering and thermal stress behavior under the thermal gradient test conditions.
Orthogonalizing Beams to Train Unscheduled Terminals (2009)

Recent work on wireless beamforming has focused on multiuser diversity effects, where terminals in a cellular system are chosen opportunistically from a pool of terminals based on their responses to test beams. Orthogonality between the test beams is typically chosen to aid subsequent interference-free transmission to the corresponding terminals. However, much of this work assumes that i) the pool of terminals on a given time-frequency resource is large enough that a subset of terminals can be found whose spatial signatures match the orthogonal test beams; ii) the responses to the test beams of the entire pool are known to the base station; iii) beamforming considerations can drive traffic scheduling and resource allocation. These conditions are not always met. Rather, we examine orthogonalizing a given set of data-carrying beams for terminals that are scheduled on distinct time-frequency resources. The scheduled terminals are not chosen for their spatial signatures, but rather for their need to receive data. Our orthogonalization is chosen to maximize the beamforming gain to the scheduled terminals, whose channels are generally not spatially orthogonal. Unscheduled terminals may then ldquoeavesdroprdquo on pilots embedded in the orthogonal beams and thereby learn their own channel state information. This process eliminates the need for separate dedicated orthogonal training signals. We show how this scheme may be deployed in frequency-division duplex and time-division duplex systems. We quantify the price in beamforming gain paid for orthogonalizing a set of beams. One result analytically shows that the average price is at most 1.4 dB in SNR.
Systems and methods for separation and purification of products (2023)

There are provided methods and systems for an electrochemical cell including an anode and a cathode where the anode is contacted with a metal ion that converts the metal ion from a lower oxidation state to a higher oxidation state. The metal ion in the higher oxidation state is reacted with an unsaturated hydrocarbon and/or a saturated hydrocarbon to form products. Separation and/or purification of the products as well as of the metal ions in the lower oxidation state and the higher oxidation state, is provided herein.
Palladium Catalyzed Suzuki Cross-Coupling Reactions in Ambient-Temperature Ionic Liquids (2002)

Palladium catalyzed Suzuki cross-coupling reactions have been investigated in the ambient temperature ionic liquid, 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim][BF4]) and have been found to exhibit unprecedented reactivities in addition to easy product isolation and catalyst recycling. Furthermore, the in situ formation of the mixed phosphine imidazolylidene palladium complex, [(PPh3)2Pd(bmimy)X] [BF4] (where: bmimy = 1-butyl-3-methylimidazolylidene, X = Cl or Br), from [bmim][BF4] has been detected under conditions similar to many ionic liquid mediated palladium catalyzed coupling reactions. Ionic liquid solutions of the independently prepared complex give rise to an extremely potent catalytic system.
The Identifiable Virtual Patient Model: Comparison of Simulation and Clinical Closed-Loop Study Results (2012)

Closed-loop simulations using an IVP model can predict clinical study outcomes in patients studied independently from those used to develop the model.
Supplementary Table 1 from Tumor Suppressor Functions of miR-133a in Colorectal Cancer (2023)

&lt;p&gt;PDF file - 48K, Characteristics of the CRC patients for miRNA array.&lt;/p&gt;
Spin-valve thermal stability: The effect of different antiferromagnets (2000)

This investigation focused on how spin-valve thermal stability is related to different antiferromagnetic materials: FeMn, IrMn, NiMn, PtMn, and PtPdMn. Measurements of the spin-valve exchange biasing field versus temperature show the following relationship in blocking temperatures: FeMn&amp;lt;IrMn&amp;lt;PtPdMn&amp;lt;PtMn&amp;lt;NiMn. Looking at the blocking temperature distributions, both FeMn and IrMn show sharp peaks, but at low temperatures (∼110 °C). In the case of the other materials, the distribution peaks at much higher temperature (&amp;gt;250 °C), but are broader. Pinned angle rotation and giant magnetoresistance versus temperature measurements give the same thermal stability hierarchy, as well as providing information about interdiffusion in these spin-valves. For comparison, synthetic antiferromagnet spin-valves (based on IrMn and PtMn) were also measured. The synthetic structures did not show significantly different blocking temperatures or giant magnetoresistance temperature dependence than standard spin-valves. However, blocking temperature distribution and pinned layer rotation measurements showed improved stability for the synthetic structures, which may be attributed to the very thin effective pinned layer which results in high exchange biasing fields in these structures.
Disease Survey of Cereal Crops in Saskatchewan in 2013. (2013)

Cereal crops in Saskatchewan can suffer a number of diseases that reduce yield and quality. A disease survey was conducted in 2013 to identify pathogenic agents and assess disease severity on oat, canaryseed, barley and winter and spring wheat. Crown rust was detected at trace levels in four of 32 oat crops and the most common leaf spotting pathogens were Pyrenophora avenae and Stagnospora avenae, similar to previous years. On canaryseed, Septoria triseti was observed from plating of leaf samples and appeared to be highest in west-central SK and lowest in the north-east. Fusarium avenaceum was identified from plating of seeds in four of 26 crops, but only at low levels. In barley, only two crops were affected by stripe rust, but leaf spots symptoms observed on most crops, most commonly caused by Cochliobolus sativus and Pyrenophora teres; Septoria passerinii was identified in a few samples. Severe stripe rust infection was observed in seven of 89 winter wheat crops, but 60 crops were stripe rust-free. In winter wheat fusarium head blight was generally low in most regions of SK, except near Outlook, where severity was much higher. In spring wheat, stripe rust infection was observed in eight of 17 crops and was severe in one crop.
Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in s=13  TeV pp collisions with the ATLAS detector (2020)

A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of ffiffi ffi s p 13 TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139 fb -1 . A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015-2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV.
Protonation sites and dissociation mechanisms of t‐butylcarbamates in tandem mass spectrometric assays for newborn screening (2011)

Structures of tert-butylcarbamate ions in the gas-phase and methanol solution were studied for simple secondary and tertiary carbamates as well as for carbamate-containing products and internal standards for lysosomal enzyme assays used in newborn screening of a α-galactosidase A deficiency (Fabry disease), mucopolysaccharidosis I (Hurler disease), and mucopolysaccharidosis II (Hunter disease). The protonation of simple t-butylcarbamates can occur at the carbonyl group, which is the preferred site in the gas phase. Protonation in methanol solution is more favorable if occurring at the carbamate nitrogen atom. The protonation of more complex t-butylcarbamates occurs at amide and carbamate carbonyl groups, and the ions are stabilized by intramolecular hydrogen bonding, which is affected by solvation. Tertiary carbamates containing aminophenol amide groups were calculated to have substantially greater gas-phase basicities than secondary carbamates containing coumarin amide groups. The main diagnostically important ion dissociation by elimination of 2-methylpropene (isobutylene, i-C(4)H(8)) and carbon dioxide is shown by experiment and theory to proceed in two steps. Energy-resolved collision-induced dissociation of the Hurler's disease enzymatic product ion, which is a coumarin-diamine linker-t-butylcarbamate conjugate (3a(+)), indicated separate energy thresholds for the loss of i-C(4)H(8) and CO(2). Computational investigation of the potential energy surface along two presumed reaction pathways indicated kinetic preference for the migration of a t-butyl hydrogen atom to the carbamate carbonyl resulting in the isobutylene loss. The consequent loss of CO(2) required further proton migrations that had to overcome energy barriers.