gebhart/patrepeval huggingface dataset:
A Data Analytics Framework for Aggregate Data Analysis (2018)

In many contexts, we have access to aggregate data, but individual level data is unavailable. For example, medical studies sometimes report only aggregate statistics about disease prevalence because of privacy concerns. Even so, many a time it is desirable, and in fact could be necessary to infer individual level characteristics from aggregate data. For instance, other researchers who want to perform more detailed analysis of disease characteristics would require individual level data. Similar challenges arise in other fields too including politics, and marketing. In this paper, we present an end-to-end pipeline for processing of aggregate data to derive individual level statistics, and then using the inferred data to train machine learning models to answer questions of interest. We describe a novel algorithm for reconstructing fine-grained data from summary statistics. This step will create multiple candidate datasets which will form the input to the machine learning models. The advantage of the highly parallel architecture we propose is that uncertainty in the generated fine-grained data will be compensated by the use of multiple candidate fine-grained datasets. Consequently, the answers derived from the machine learning models will be more valid and usable. We validate our approach using data from a challenging medical problem called Acute Traumatic Coagulopathy.
Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium (2014)

Findings from Mendelian randomisation analyses do not support a causal role of smoking heaviness in the development of depression and anxiety.
Seismic prediction of stringer sands in offshore Saudi Arabia (2008)

A 3D simultaneous inversion of angle‐stacked seismic amplitude data was used to produce a Vp/Vs volume. These data were used to validate planned well trajectories and to geosteer within sand stringers in an Arabian Gulf field producing from mid‐Cretaceous clastics. Prior to the inversion a feasibility study based on the well information was conducted. Six partial angle stacks were inverted for an optimal elastic model of P‐impedance, Vp/Vs, and density. The resulting Vp/Vs volume was converted to depth, and used to help geosteer near‐horizontal well paths within a clastic interval containing channel sand stringers. This case study illustrates how these data were used to validate a proposed well sidetrack that eventually drilled over 1800 feet of oil‐filled sand stringers from an oil production platform.
ChemInform Abstract: Preparation of Mappicine Ketones from Camptothecins: Chemistry of the Camptothecin E Ring. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Targeted Polymersome Delivery of siRNA Induces Cell Death of Breast Cancer Cells Dependent upon Orai3 Protein Expression (2012)

Polymersomes, polymeric vesicles that self-assemble in aqueous solutions from block copolymers, have been avidly investigated in recent years as potential drug delivery agents. Past work has highlighted peptide-functionalized polymersomes as a highly promising targeted delivery system. However, few reports have investigated the ability of polymersomes to operate as gene delivery agents. In this study, we report on the encapsulation and delivery of siRNA inside of peptide-functionalized polymersomes composed of poly(1,2-butadiene)-b-poly(ethylene oxide). In particular, PR_b peptide-functionalized polymer vesicles are shown to be a promising system for siRNA delivery. PR_b is a fibronectin mimetic peptide targeting specifically the α5β1 integrin. The Orai3 gene was targeted for siRNA knockdown, and PR_b-functionalized polymer vesicles encapsulating siRNA were found to specifically decrease cell viability of T47D breast cancer cells to a certain extent, while preserving viability of noncancerous MCF10A breast cells. siRNA delivery by PR_b-functionalized polymer vesicles was compared to that of a current commercial siRNA transfection agent, and produced less dramatic decreases in cancer cell viability, but compared favorably in regards to the relative toxicity of the delivery systems. Finally, delivery and vesicle release of a fluorescent encapsulate by PR_b-functionalized polymer vesicles was visualized by confocal microscopy, and colocalization with cellular endosomes and lysosomes was assessed by organelle staining. Polymersomes were observed to primarily release their encapsulate in the early endosomal intracellular compartments, and data may suggest some escape to the cytosol. These results represent a promising first generation model system for targeted delivery of siRNA.
Synthesis of Dihydroisoxazole Nucleoside and Nucleotide Analogs (1997)

The dihydroisoxazole nucleosides as well as their phosphonate derivatives were efficiently prepared via 1,3-dipolar cycloaddition reactions of nitrile oxides with corresponding vinyl nucleoside bases for antiviral studies.
Comparing directions of Acropora coral adaptive response to environmental gradients (2022)

As climate change progresses, reef-building corals face multiple environmental stressors that they must adapt to. Can corals adapt to all these stressors at the same time, or would some adaptations exclude others (i.e., a genetic tradeoff)? Here, we reanalyzed RNA-seq and Tag-seq data from four studies that compared gene expression in corals from tidal pools of different daily heat stress levels, with varying proximity to a CO seep, containing different kinds of algal symbionts, and separated by 15 degrees of latitude. We computed both the genetic divergence ( F ) and log-fold expression change per gene for each contrast, and then compared these results to see whether the same genes were involved in adaptation and/or acclimatization to different environmental gradients. We find that genetic divergence patterns are entirely independent from each other (with the exception of just two shared F outliers between the two cases of CO adaptation), while at the gene expression level there is significant overlap in up- and down-regulated genes among multiple environmental contrasts. These results suggest that coral populations maximize their local fitness predominantly via gene expression plasticity (involving similar pathways) rather than through selection-driven genetic divergence. Still, there remains the possibility of highly polygenic adaptation with extensive redundancy (many alternative genetic ways to achieve the same phenotype). Regardless of the mechanism, the overall lack of tradeoffs that we observed here suggests that corals have substantial capacity to withstand multiple simultaneous stressors.
Sensitivity Analysis for Causal Inference under Unmeasured Confounding and Measurement Error Problems (2013)

In this article, we present a sensitivity analysis for drawing inferences about parameters that are not estimable from observed data without additional assumptions. We present the methodology using two different examples: a causal parameter that is not identifiable due to violations of the randomization assumption, and a parameter that is not estimable in the nonparametric model due to measurement error. Existing methods for tackling these problems assume a parametric model for the type of violation to the identifiability assumption and require the development of new estimators and inference for every new model. The method we present can be used in conjunction with any existing asymptotically linear estimator of an observed data parameter that approximates the unidentifiable full data parameter and does not require the study of additional models.
Experience with an interactive attribute-based user information environment (2002)

This paper explores an attribute-based approach to storing information in the context of a file system that supports extended attributes about files and a mechanism to manipulate files based on logical queries and comparisons of attributes. The novel aspects of our system are that it is sophisticated enough to operate as a user's primary method of interaction with the operating system and that it supports derived attributes whose values are derived at look-up time. Organizational mechanisms are explored to aid in the navigation of the system. We implemented our system as a user-level NFS server that supports attribute-based naming of files and other objects. We discuss its details, our experiences with it and performance comparisons between it and a traditional hierarchical file system. Overall the work is successful by demonstrating the feasibility of an attribute-based environment that can be a user's interface to the underlying system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Bovine lactoferrin added to triple therapy increased Helicobacter pylori eradication rate (2006)

TherapeuticsSeptember 1, 2006Bovine lactoferrin added to triple therapy increased Helicobacter pylori eradication rateFrancis K.L. Chan, MD, MBChB, FRCP, FACG, Vincent W.S. Wong, MD, MBChB, MRCPFrancis K.L. Chan, MD, MBChB, FRCP, FACGChinese University of Hong Kong, Hong Kong, China (F.K.C., V.W.W.)Search for more papers by this author, Vincent W.S. Wong, MD, MBChB, MRCPChinese University of Hong Kong, Hong Kong, China (F.K.C., V.W.W.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2006-145-2-049 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareFacebookTwitterLinkedInRedditEmail Source CitationDi Mario F, Aragona G, Dal Bó N, et al. Bovine lactoferrin for Helicobacter pylorieradication: an open, randomized, multicentre study. Aliment Pharmacol Ther. 2006;23:1235-40. https://pubmed.ncbi.nlm.nih.gov/16611285Clinical Impact RatingsGastroenterology: References1 Chan FK, Chung SC, Suen BY, et al. Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen. N Engl J Med. 2001;344:967-73. [PMID: 11274623] Google Scholar2 Chan FK, Leung WK. Peptic-ulcer disease. Lancet. 2002;360:933-41. [PMID: 12354485] Google Scholar3 De Francesco V, Margiotta M, Zullo A, et al. Clarithromycin-resistant genotypes and eradication of Helicobacter pylori. Ann Intern Med. 2006;144:94-100. [PMID: 16418408] Google Scholar4 Di Mario F, Aragona G, Dal Bo N, et al. Use of bovine lactoferrin for Helicobacter pylori eradication. Dig Liver Dis. 2003;35:706-10. [PMID: 14620619] Google Scholar Author, Article, and Disclosure InformationAffiliations: Chinese University of Hong Kong, Hong Kong, China (F.K.C., V.W.W.) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails September 1, 2006Volume 145, Issue 2Page: 49KeywordsAllergic diseasesAllergy and immunologyAntibioticsAntigensCancer preventionDrugsGastritisHelicobacter pyloriHelicobacter pylori infectionLactationPeptic ulcersPopulation statisticsRenal diseasesStomachSurgeryUlcersUrea ePublished: 9 March 2020 Issue Published: September 1, 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Cross Sections for Charge Exchange and Ionization of High-Energy Ions in Noble Gases (2007)

Interactions of charge exchange and ionization of fast, low-charged heavy ions are very important in heavy ion beam inertial confinement fusion. These effects are crucial indetermination of the final focusing in the chamber. However, corresponding cross section data is very limited and/or not accurate over the entire range of energies and ions of interest. This paper reports on our recent studies of cross sections for interactions of heavy ions with noble gases. Since a quantum mechanical treatment encounters a complex many-body problem, a classical trajectory Monte Carlo method is employed. The distribution of inner electrons is estimated by a modified Hartree-Fock model for the purpose of decreasing the number of electron orbits calculated, a micro-canonical ensemble for the initial electron probability distribution is introduced to describe quantum mechanical uncertainty. Cross sections are evaluated over a limited energy range; then scaling laws are developed to reflect the change probability for the beam charge state over a larger energy range.
Non-p.V600E BRAF Mutations Are Common Using a More Sensitive and Broad Detection Tool (2015)

The NGS assay demonstrated a high analytic sensitivity and a broad reportable range for clinical detection of BRAF mutations. Elucidating the spectrum of non-p. V600E BRAF mutations in different malignancies is a first step toward understanding their clinical significance.
Preparation and Agglutination of Immuno-Nanolatex for Malaria Diagnosis (2009)

International audience
Oligo(4-aminopiperidine-4-carboxylic acid): An Unusual Basic Oligopeptide with an Acid-Induced Helical Conformation (2010)

In sharp contrast with helical polypeptides carrying basic side chains, Api(8), a basic oligopeptide containing the non-natural achiral amino acid 4-aminopiperidine-4-carboxylic acid (Api), adopts a helical conformation only in acidic media. Alkaline titration of a protonated Api(8) oligomer appended with a leucine derivative at its N-terminus showed that disruption of its helical conformation occurs in a pH range of 7-10. NMR studies indicated that the piperidine groups in Api(8), when nonprotonated, possibly interact with the proximal amide protons in the peptide backbone and hamper the formation of the H-bonding network responsible for the helical conformation. The helical structure is induced not only by protonation but also by acylation of the piperidine groups.
Combination of 3des with dct algorithm in message security (2020)

Abstract In the digital era, communication through computer networks plays an important role. Through electronic communication, a person can make transactions or communication very quickly and practically. Sending data / messages from one place to another is much constrained by the issue of confidentiality. There are many ways you can hide data / messages that will be sent. First, using cryptographic techniques, namely by encoding data / messages using certain algorithms. Another technique is to insert a message that will be sent to other media, so that the message will be hidden and what will appear is other media used to insert messages.Here will be performed a Performance Analysis of the Combination of 3DES and DCT Algorithms in Securing Message Files into the Image.
Microscopic Magnetic Characteristics of CoCrPt-Patterned Media Made by Artificially Aligned Self-Organized Mask (2007)

The microscopic magnetic characteristics of CoCrPt-patterned media after magnetic recording by a ring head were investigated. The media consists of two rows of aligned CoCrPt dots with a diameter of 40 nm. The magnetization reversal of each dot is clearly observed by magnetic force microscopy (MFM). A few misreversed dots were observed in the written "bit" patterns. The distribution of coercivity Hc was investigated by MFM using dot-by-dot analysis. It was found that Hc is about 4 kOe on the average with a wide distribution ranging from 0.5 to 7.5 kOe. This large distribution of Hc causes these magnetization reversal defects. One possible origin of the large Hc distribution is the grain boundary observed in each grain of the CoCrPt layer.
Facial deblur inference to improve recognition of blurred faces (2009)

This paper proposes a novel method for deblurring facial images to recognize faces degraded by blur. The main problem is how to infer a point spread function (PSF) representing the process of blur. Inferring a PSF from a single facial image is an ill-posed problem. To make this problem more tractable, our method uses learned prior information derived from a training set of blurred facial images of several individuals. We construct a feature space such that blurred faces degraded by the same PSF are similar to one another and form a cluster. During training, we compute a statistical model of each PSF cluster in this feature space. For PSF inference we compare a query image of unknown blur with each model and select the closest one. Using the PSF corresponding to that model, the query image is deblurred, ready for recognition. Experiments on a standard face database artificially degraded by focus or motion blur show that our method substantially improves the recognition performance compared with state-of-the-art methods. We also demonstrate improved performance on real blurred images.
A fully matched LTE-A carrier aggregation quadplexer based on BAW and SAW technologies (2014)

An inter-band carrier aggregation (CA) quadplexer allows doubling the download rates and is therefore an important element in upcoming mobile phone systems. In a duplexer design, both Tx and Rx filters should behave like an open-circuit for respective counter-bands at the antenna port. Additionally, they have to attain high suppression in their counter-band to get good in-band isolation. The situation gets more difficult and challenging for a CA quadplexer. Besides an open-circuit requirement for now 3 bands simultaneously, each Tx filter should achieve high suppression in the frequency range of both Rx filters in order to get high in-band and cross-isolation. The same applies for each Rx filter. Generally, it is not sufficient to simply expand the well-known topology concepts of duplexers rather a different design methodology is required. In this paper we will discuss several approaches to realize a CA quadplexer and present an implementation of a B25-B4 CA quadplexer sized 3.6×2.0×0.8mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> utilizing the company's advanced acoustic wave filtering technologies: bulk acoustic wave (BAW) and surface acoustic wave (SAW).
NASICON-type Li₁₊₂ₓZr₂₋ₓCaₓ(PO₄)₃ with high ionic conductivity at room temperature (2011)

Compounds with nominal formula Li₁₊₂ₓZr₂₋ₓCaₓ(PO₄)₃ (x = 0.1–0.4) were synthesized and the substitution effects on surface morphology, density and ionic conductivity were investigated. With the introduction of Ca²⁺, the rhombohedral NASICON structure is retained at room temperature. The maximum Li⁺-ion conductivity at room temperature is 0.49 × 10⁻⁴ S cm⁻¹ with an activation energy of 0.48 eV with x = 0.1. A Ca²⁺-rich grain boundary is formed with x > 0.1, which results in a significant decrease in density and ionic conductivity.
Certificateless aggregate signature with efficient verification (2014)

Certificateless public key cryptography CL-PKC is a cryptosystem solving the key escrow problem of identity-based cryptography. One of the applications of CL-PKC is certificateless aggregate signature CLAS that in practice can be used to efficiently verify concealed data aggregation in wireless sensor networks. CLAS is referred to as an extension of certificateless signature, which in particular performs verification for many signatures efficiently. Therefore, not only plenty of CLAS schemes have been proposed but also the security models of CLAS were introduced in the literature. Recently, some CLAS schemes are extended from specific certificateless signature CLS schemes. However, we found that two certificateless signature CLS and their corresponding CLAS schemes are not secure. In this paper, we simplify the relation of security definitions of CLS and CLAS. Then, a new CLAS scheme is proposed, which leads to the advantages of both certificateless cryptography and aggregate signature. Moreover, our scheme only depends on constant pairing operations to verify a large number of signatures per time, because pairing is a complicated operation with high cost in computations. Copyright © 2014 John Wiley & Sons, Ltd.
The challenges of emerging software eco-systems (keynote) (2013)

New opportunities for software-intensive system configurations are arriving on the market; these include cyber-physical, cyber-social, and cloud structures. Because of the convenience and cost-savings opportunities they offer, these capabilities and configurations will be adopted, most likely quickly and at large scale. Some of these configurations, however, have the potential to create (or already are creating) significant unintended problems and vulnerabilities. The author identifies a range of such unintended problems and vulnerabilities, and indicates the types of research and new insights that will be needed so as to allow society to obtain the benefits promised by these emerging opportunities.
ChemInform Abstract: Differential Binding and Dopamine Uptake Activity of Cocaine Analogues Modified at Nitrogen. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Summary Statement: Biology of Spine Fusion, Bone Graft Substitutes, and the Burden of Proof (2002)

It has been more than 35 years since the description of the osteoinductive principle by Urist and colleagues, yet this discovery still has not been translated into widespread clinical use. Paramount to translational research is the development and validation of animal models and the definition of appropriate design parameters to afford safe interpretation of data. This article reviews what is known about the biology of spine fusion and bone graft substitutes. The authors outline basic principles of use to help the practicing surgeon make decisions in the choice of a bone graft substitute. Finally, a critical review of animal models is provided to serve as a foundation for interpretation of preclinical studies on the various bone morphogenetic proteins used for spine fusion.
Perceptions of Tenured Faculty Members About the Post-tenure Review Process in Tennessee Community Colleges (1997)

The purpose of this study is to determine if differences exist between tenured faculty members perceptions about what actually occurs during the post-tenure review process and what they believe should occur in the twelve community colleges in the Tennessee Board of Regents System. This study presents the status of higher education tenure from a historical and legal basis nationally and in Tennessee. The study also presents various models of faculty evaluation and post-tenure review practices in higher education nationwide, as well as in Tennessee. The data in this study are analyzed through descriptive statistics and presented the demographic data including campus location, age, years of teaching experience, ethnicity, highest degree obtained, faculty rank, and gender. Further demographic data analysis, ANOVA and t-tests, finds no significant differences among tenured faculty concerning the post-tenure review process. The review of literature and data presented in this study implies that post-tenure review is most accepted when administrators effectively communicate the purpose of post-tenure review, routinely provide an orientation to the process, generally familiarize themselves with the concerns and perceptions of those undergoing the post-tenure review, and clearly ensure that the concept of academic freedom is not undermined.