gebhart/patrepeval huggingface dataset:
Thermal Image Processing via Physics-Inspired Deep Networks (2021)

We introduce DeepIR, a new thermal image processing framework that combines physically accurate sensor modeling with deep network-based image representation. Our key enabling observations are that the images captured by thermal sensors can be factored into slowly changing, scene-independent sensor non-uniformities (that can be accurately modeled using physics) and a scene-specific radiance flux (that is well-represented using a deep network-based regularizer). DeepIR requires neither training data nor periodic ground-truth calibration with a known black body target–making it well suited for practical computer vision tasks. We demonstrate the power of going DeepIR by developing new denoising and super-resolution algorithms that exploit multiple images of the scene captured with camera jitter. Simulated and real data experiments demonstrate that DeepIR can perform high-quality non-uniformity correction with as few as three images, achieving a 10dB PSNR improvement over competing approaches.
Data from FLT3 Ligand Enhances the Cancer Therapeutic Potency of Naked RNA Vaccines (2023)

&lt;div&gt;Abstract&lt;p&gt;Intranodal immunization with antigen-encoding naked RNA may offer a simple and safe approach to induce antitumor immunity. RNA taken up by nodal dendritic cells (DC) coactivates toll-like receptor (TLR) signaling that will prime and expand antigen-specific T cells. In this study, we show that RNA vaccination can be optimized by coadministration of the DC-activating Fms-like tyrosine kinase 3 (FLT3) ligand as an effective adjuvant. Systemic administration of FLT3 ligand prior to immunization enhanced priming and expansion of antigen-specific CD8&lt;sup&gt;+&lt;/sup&gt; T cells in lymphoid organs, T-cell homing into melanoma tumors, and therapeutic activity of the intranodal RNA. Unexpectedly, plasmacytoid DCs (pDC) were found to be essential for the adjuvant effect of FLT3 ligand and they were systemically expanded together with conventional DCs after treatment. In response to FLT3 ligand, pDCs maintained an immature phenotype, internalized RNA, and presented the RNA-encoded antigen for efficient induction of antigen-specific CD8&lt;sup&gt;+&lt;/sup&gt; T-cell responses. Coadministration of FLT3 ligand with RNA vaccination achieved remarkable cure rates and survival of mice with advanced melanoma. Our findings show how to improve the simple and safe strategy offered by RNA vaccines for cancer immunotherapy. &lt;i&gt;Cancer Res; 71(19); 6132–42. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Next-generation broadband optical access network technologies [Guest editorial (2010)

Broadband access networking is an important form of basic infrastructure that supports competitive social and economic development. Emerging broadband applications such as IPTV, real-time network gaming, backhauling of broadband wireless connection data etc., demand new technological innovations to meet their ever-increasing performance-to-cost requirements. Optical fiber has been established as a future-proof medium capable of facilitating the next-generation network applications. For instance, in Feb. 2010 Google just announced the plans to build an experimental gigabit-per-second fiber-to-the-home (FTTH) network to households in North America for testing out new concepts in technologies and applications. Worldwide, FTTH deployment had surpassed thirty million users in 2009 and is still continuing to grow at a rapid pace.
Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) ORF54 encodes a functional dUTPase expressed in the lytic replication cycle. (1999)

The complete ORF54 of the Kaposi's sarcoma-associated herpesvirus (KSHV) (human herpesvirus-8; HHV-8) was cloned and expressed in E. coli. The results show that KSHV/HHV-8 ORF54 encodes a functional dUTPase which specifically hydrolyses dUTP to dUMP. Monoclonal antibodies against the HHV-8 dUTPase detected a protein with the expected molecular mass of 35 kDa in HHV-8-infected BCBL-1 cells. Induction of the lytic replication cycle of HHV-8 by treatment of BCBL-1 cells with the phorbol ester TPA resulted in an increased expression of the protein which was not inhibited by phosphonoacetic acid, indicating that the protein is expressed early in the lytic replication cycle. Moreover, the sporadic expression of the HHV-8 dUTPase in tissue sections of Kaposi's sarcoma was detected by immunohistochemistry.
Perceptual Segmentation: Combining Image Segmentation With Object Tagging (2010)

Human observers understand the content of an image intuitively. Based upon image content, they perform many image-related tasks, such as creating slide shows and photo albums, and organizing their image archives. For example, to select photos for an album, people assess image quality based upon the main objects in the image. They modify colors in an image based upon the color of important objects, such as sky, grass or skin. Serious photographers might modify each object separately. Photo applications, in contrast, use low-level descriptors to guide similar tasks. Typical descriptors, such as color histograms, noise level, JPEG artifacts and overall sharpness, can guide an imaging application and safeguard against blunders. However, there is a gap between the outcome of such operations and the same task performed by a person. We believe that the gap can be bridged by automatically understanding the content of the image. This paper presents algorithms for automatic tagging of perceptual objects in images, including sky, skin, and foliage, which constitutes an important step toward this goal.
Molecular organic thin-film solar cells deposited on fibers (2008)

We discuss a fiber-shaped organic photovoltaic (PV) cell that utilizes concentric thin films of small molecular weight compounds and metals, permitting illumination normal to the fiber axis. Individual PV fibers exhibit performance inferior to planar cells for illumination normal to the fiber axis, but are projected to have superior averaged power generation for systems without solar tracking.
Immunlymphszintigraphie: Ein neues Verfahren für nicht-invasives Lymphknoten-Staging, dargestellt am Beispiel des Mammakarzinoms (2008)

In the course of a prospective study 43 women underwent axillary immunolymphoscintigraphy (ILS) shortly before a planned operation for suspected carcinoma of the breast. The aim was to test the feasibility of this procedure for the noninvasive staging of lymph-nodes. Three antibodies were used: HMFG-1 (3 patients), HMFG-2 (13) and 3C6F9 (27). The diagnosis was confirmed in 35 patients. They underwent radical mastectomy with removal of the lymph-nodes. There were marked differences in the usefulness of HMFG-2 and 3C6F9 for ILS in these circumstances. There were too few patients to evaluate HMFG-1. Sensitivity and specificity of the test were 0.57 and 0.83, respectively, for HMFG-1 and 0.83 and 0.93 for 3C6F9.
The Amyloid Precursor Protein Interacts with GoHeterotrimeric Protein within a Cell Compartment Specialized in Signal Transduction (1999)

The function of the beta-amyloid protein precursor (betaAPP), a transmembrane molecule involved in Alzheimer pathologies, is poorly understood. We recently reported the presence of a fraction of betaAPP in cholesterol and sphingoglycolipid-enriched microdomains (CSEM), a caveolae-like compartment specialized in signal transduction. To investigate whether betaAPP actually interferes with cell signaling, we reexamined the interaction between betaAPP and Go GTPase. In strong contrast with results obtained with reconstituted phospholipid vesicles (Okamoto et al., 1995), we find that incubating total neuronal membranes with 22C11, an antibody that recognizes an N-terminal betaAPP epitope, reduces high-affinity Go GTPase activity. This inhibition is specific of Galphao and is reproduced, in the absence of 22C11, by the addition of the betaAPP C-terminal domain but not by two distinct mutated betaAPP C-terminal domains that do not bind Galphao. This inhibition of Galphao GTPase activity by either 22C11 or wild-type betaAPP cytoplasmic domain suggests that intracellular interactions between betaAPP and Galphao could be regulated by extracellular signals. To verify whether this interaction is preserved in CSEM, we first used biochemical, immunocytochemical, and ultrastructural techniques to unambiguously confirm the colocalization of Galphao and betaAPP in CSEM. We show that inhibition of basal Galphao GTPase activity also occurs within CSEM and correlates with the coimmunoprecipitation of Galphao and betaAPP. The regulation of Galphao GTPase activity by betaAPP in a compartment specialized in signaling may have important consequences for our understanding of the physiopathological functions of betaAPP.
Evaluation of the effect of azapropazone on neutrophil migration in regional myocardial ischaemia/reperfusion injury in rabbits (1990)

1. The purpose of the present study was to determine the myocardial cytoprotective efficacy of azapropazone (AZA) and its potential site of action on neutrophil infiltration into reperfused/ischaemic myocardium with or without in vivo activation of neutrophils in rabbits. 2. AZA, 100 mg kg-1, was administered i.v. 10 min after occlusion of the left circumflex (LCX) artery in rabbits with and without pretreatment with phorbol myristate acetate ester (PMA). The LCX occlusion was then released at 10 min after AZA administration. Haemodynamic parameters (heart rate, LV pressure, mean arterial blood pressure and dp/dt) were monitored throughout the experiment. After 60 min reperfusion, the area at risk was delineated and the heart was then excised and divided into epi- and endocardial pieces for analysis of myeloperoxidase activity. 3. AZA inhibited neutrophil infiltration into the reperfused/ischaemic rabbit myocardium with and without PMA treatment. The inhibition of neutrophil infiltration was more apparent in the epicardium than in the endocardium. Additionally, AZA inhibited to a similar extent the in vivo PMA-stimulated neutrophil migration into the epicardium and endocardium area at risk. AZA had no significant effect on the haemodynamic parameters as compared to control. 4. AZA administered in an anaesthetized rabbit model of LCX occlusion/reperfusion resulted in the reduction of infarct size. 5. It is concluded that AZA has significant inhibitory effects on neutrophil migration which might contribute to its myocardial cytoprotective effect.
Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3S,4S)-3-Amino-4-fluorocyclopentenecarboxylic Acid (2023)

Ornithine aminotransferase (OAT) is overexpressed in hepatocellular carcinoma (HCC), and we previously showed that inactivation of OAT inhibits the growth of HCC. Recently, we found that (3<i>S</i>,4<i>S</i>)-3-amino-4-fluorocyclopentenecarboxylic acid (<b>5</b>) was a potent inactivator of γ-aminobutyric acid aminotransferase (GABA-AT), proceeding by an enamine mechanism. Here we describe our investigations into the activity and mechanism of <b>5</b> as an inactivator of human OAT. We have found that <b>5</b> exhibits 10-fold less inactivation efficiency (<i>k</i><sub>inact</sub>/<i>K</i><sub>I</sub>) against <i>h</i>OAT than GABA-AT. A comprehensive mechanistic study was carried out to understand its inactivation mechanism with <i>h</i>OAT. p<i>K</i><sub>a</sub> and electrostatic potential calculations were performed to further support the notion that the α,β-unsaturated alkene of <b>5</b> is critical for enhancing acidity and nucleophilicity of the corresponding intermediates and ultimately responsible for the improved inactivation efficiency of <b>5</b> over the corresponding saturated analogue (<b>4</b>). Intact protein mass spectrometry and the crystal structure complex with <i>h</i>OAT provide evidence to conclude that <b>5</b> mainly inactivates <i>h</i>OAT through noncovalent interactions, and that, unlike with GABA-AT, covalent binding with <i>h</i>OAT is a minor component of the total inhibition which is unique relative to other monofluoro-substituted derivatives. Furthermore, based on the results of transient-state measurements and free energy calculations, it is suggested that the α,β-unsaturated carboxylate group of PLP-bound <b>5</b> may be directly involved in the inactivation cascade by forming an enolate intermediate. Overall, compound <b>5</b> exhibits unusual structural conversions which are catalyzed by specific residues within <i>h</i>OAT, ultimately leading to an enamine mechanism-based inactivation of <i>h</i>OAT through noncovalent interactions and covalent modification.
Development of a Miniature Five Fingered Robot Hand using Elastic Hinges as Joints (2003)

本研究では, 小型で多自由度な運動を実現するロボットハンドを開発するために, 関節に弾性ヒンジを用いたワイヤ駆動機構を提案する。提案した機構を用いて18自由度の小型ロボットハンドを開発する。
Atrioventricular Node Ablation in Langendorff-Perfused Porcine Hearts Using Carbon Ion Particle Therapy (2015)

This is the first report of the application of a (12)C beam for ablation of cardiac tissue to treat arrhythmias. Catheter-free ablation using 12C beams is feasible and merits exploration in intact animal studies as an energy source for arrhythmia elimination.
High-Spin Oxyphenylbenzo-Annelated Dehydro[12]annulene (1999)

Abstract A ground state quartet molecule, 2,8,14-trisoxyphenyltribenzotrisdehydro[12]annulene, was synthesized; the dehydroannulene acted as an effective ferromagnetic coupler for the pendant spins.
Asymmetric Hydrogenation of Indazole-Containing Enamides Relevant to the Synthesis of Zavegepant Using Neutral and Cationic Cobalt Precatalysts (2023)

The cobalt-catalyzed asymmetric hydrogenation of indazole-containing enamides relevant to the synthesis of the calcitonin gene-related peptide (CGRP) receptor antagonist, zavegepant (<b>1</b>), approved for the treatment of migraines, is described. Both neutral bis(phosphine)cobalt(II) and cationic bis(phosphine)cobalt(I) complexes served as efficient precatalysts for the enamide hydrogenation reactions, providing excellent yield and enantioselectivities (up to >99.9%) for a range of related substrates, though key reactivity differences were observed. Hydrogenation of indazole-containing enamide, methyl (<i>Z</i>)-2-acetamido-3-(7-methyl-1<i>H</i>-indazol-5-yl)acrylate, was performed on a 20 g scale.
Structural and optical properties of Eu-doped GaN nanocolumns on (111) Si substrates grown by RF-plasma-assisted molecular beam epitaxy (2016)

Abstract Eu-doped GaN (GaN:Eu) shows a sharp line emission and the thermal stability of the emission wavelength. To improve their optical properties, GaN:Eu nanocolumns were grown on GaN nanocolumn platforms with high crystalline quality by RF-plasma-assisted molecular beam epitaxy. The GaN:Eu growth temperature strongly affected the nancolumn configuration. Although a high growth temperature of more than 700 °C enhanced lateral growth, a low growth temperature of 600 °C led to independent GaN:Eu nanocolumns. Although it was revealed that an increase in Eu concentration brought about polycrystalline growth, the optically active site concentration increased with increasing Eu concentration without concentration quenching, which suggests that the nanocolumn crystal is a valuable material for developing the novel optical devices utilizing GaN:Eu.
Simulations and Experiments on Low-Pressure Permeation of Fabrics: Part II—The Variable Gap Model and Prediction of Permeability (2001)

Use of the creeping flow assumption provides a computationally efficient and accurate means of predicting flow fronts in reinforcement media in many technologically important polymer processes. In the case of fabrics, this creeping flow is shown to proceed primarily through the gaps in fabrics, with capillarity playing little if any role for commonly used materials. This finding has important implications for selection of strategy in modeling manufacturing processes of such materials. Namely, in the presence of fabric deformation which induces local shear, changes in the gap architecture greatly affect the flow patterns, and are not well predicted by tensor transformation of Darcy-type permeabilities. Asimple, classic flow model is adapted to the case of fabrics penetrated by low-pressure viscous liquids after careful analysis of fabric architecture. An applicability range of this creeping flow model, the variable gap model, is developed. The present paper gives the model assumptions, and confirmation of its agreement with more sophisticated calculations. A demonstration of the approach for an unbalanced fabric (Knytex 24 5×4 unbalanced plain-woven glass fabric) shows excellent prediction of the bounds on flow behavior, and supports our earlier experimental findings on flow front orientation. This approach also shows clear superiority to semi-empirical, geometry-based models, since no fitting parameters at all are used in the modeling: only the constituent materials’ geometry and properties are needed. This methodology is better able to predict trends in flow fronts, both qualitatively and quantitatively, than semi-empirical fitting. Extension of this work to realistic production processes is planned. 1Author to whom correspondence should be addressed. 1285 Journal ofCOMPOSITE MATERIALS, Vol. 35, No. 14/2001
Crystal structure of the complex between a single chain antibody and Neuraminidase: A basis for rational protein engineering (1993)

Crystal structure of the complex between a single chain antibody and Neuraminidase: A basis for rational protein engineering Get access Robyn L. Malby, Robyn L. Malby 1Biomolecular Research Institute and CSIRO Division of Biomolecular Engineering, Parkville. 3052. Vic. Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael C. Lawrence, Michael C. Lawrence 1Biomolecular Research Institute and CSIRO Division of Biomolecular Engineering, Parkville. 3052. Vic. Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar William A. Tulip, William A. Tulip 1Biomolecular Research Institute and CSIRO Division of Biomolecular Engineering, Parkville. 3052. Vic. Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Vincent A. Harley, Vincent A. Harley 2CSIRO Division of Biomolecular Engineering, Parkville. 3052. Vic. Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert G. Webster, Robert G. Webster 3St. Department of Virology, St. Jude Children's Research Hospital, Memphis, TN 38105. U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Peter J. Hudson, Peter J. Hudson 2CSIRO Division of Biomolecular Engineering, Parkville. 3052. Vic. Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Peter M. Colman Peter M. Colman 1Biomolecular Research Institute and CSIRO Division of Biomolecular Engineering, Parkville. 3052. Vic. Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Protein Engineering, Design and Selection, Volume 6, Issue Supplement, 1993, Page 85, https://doi.org/10.1093/protein/6.Supplement.85-a Published: 01 January 1993
Superconducting Quantum Arrays with High Spurious-Free Dynamic Range (2015)

There has been a significant progress in the development of broadband superconductor sensors / amplifiers capable of providing high Spurious-Free Dynamic Range for applications in broadband receiving systems with direct digitization of rf signals. This paper is to review our theoretical and experimental results on Superconducting Quantum Arrays suggested for broadband sensors / amplifiers including active Electrically Small Antennas.
Data from GDC-0980 Is a Novel Class I PI3K/mTOR Kinase Inhibitor with Robust Activity in Cancer Models Driven by the PI3K Pathway (2023)

&lt;div&gt;Abstract&lt;p&gt;Alterations of the phosphoinositide-3 kinase (PI3K)/Akt signaling pathway occur broadly in cancer via multiple mechanisms including mutation of the &lt;i&gt;PIK3CA&lt;/i&gt; gene, loss or mutation of phosphatase and tensin homolog (PTEN), and deregulation of mammalian target of rapamycin (mTOR) complexes. The dysregulation of this pathway has been implicated in tumor initiation, cell growth and survival, invasion and angiogenesis, thus, PI3K and mTOR are promising therapeutic targets for cancer. We discovered GDC-0980, a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2) with excellent pharmacokinetic and pharmaceutical properties. GDC-0980 potently inhibits signal transduction downstream of both PI3K and mTOR, as measured by pharmacodynamic (PD) biomarkers, thereby acting upon two key pathway nodes to produce the strongest attainable inhibition of signaling in the pathway. Correspondingly, GDC-0980 was potent across a broad panel of cancer cell lines, with the greatest potency in breast, prostate, and lung cancers and less activity in melanoma and pancreatic cancers, consistent with KRAS and BRAF acting as resistance markers. Treatment of cancer cell lines with GDC-0980 resulted in G1 cell-cycle arrest, and in contrast to mTOR inhibitors, GDC-0980 induced apoptosis in certain cancer cell lines, including those with direct pathway activation via PI3K and PTEN. Low doses of GDC-0980 potently inhibited tumor growth in xenograft models including those with activated PI3K, loss of LKB1 or PTEN, and elicited an exposure-related decrease in PD biomarkers. These preclinical data show that GDC-0980 is a potent and effective dual PI3K/mTOR inhibitor with promise for the clinic. &lt;i&gt;Mol Cancer Ther; 10(12); 2426–36. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Memory Loss in a Tantalum Oxide Memristor (2016)

The tantalum oxide memristor may have a promising future as key element in innovativevery-high speed ultra-low power extra-large density nonvolatile memories. It is therefore timely andrelevant to investigate the nonlinear dynamics of this device in view of the interesting opportunities itmay open up in the world of electronics in the years to come. In numerical simulations of an accuratemodel of the tantalum oxide memristor manufactured at Hewlett Packard Labs we observed a surprisingphenomenon which was never reported earlier. Under AC periodic excitation the memristorexhibits unique asymptotic behaviour, irrespective of the initial condition. Thus the device may bestimulated in such a way to forget its past history. This memory erase effect, unexpected in a memristordevice, is closely related to the concept of fading memory from nonlinear system theory, and wasrecently confirmed through experiments conducted on a sample device.