gebhart/patrepeval huggingface dataset:
Precursor Directed Biosynthesis of an Orthogonally Functional Erythromycin Analogue: Selectivity in the Ribosome Macrolide Binding Pocket (2012)

The macrolide antibiotic erythromycin A and its semisynthetic analogues have been among the most useful antibacterial agents for the treatment of infectious diseases. Using a recently developed chemical genetic strategy for precursor-directed biosynthesis and colony bioassay of 6-deoxyerythromycin D analogues, we identified a new class of alkynyl- and alkenyl-substituted macrolides with activities comparable to that of the natural product. Further analysis revealed a marked and unexpected dependence of antibiotic activity on the size and degree of unsaturation of the precursor. Based on these leads, we also report the precursor-directed biosynthesis of 15-propargyl erythromycin A, a novel antibiotic that not only is as potent as erythromycin A with respect to its ability to inhibit bacterial growth and cell-free ribosomal protein biosynthesis but also harbors an orthogonal functional group that is capable of facile chemical modification.
Adsorbed natural gas storage with activated carbon (1996)

Despite technical advances to reduce air pollution emissions, motor vehicles still account for 30 to 70% emissions of all urban air pollutants. The Clean Air Act Amendments of 1990 require 100 cities in the United States to reduce the amount of their smog within 5 to 15 years. Hence, auto emissions, the major cause of smog, must be reduced 30 to 60% by 1998. Natural gas con be combusted with less pollutant emissions. Adsorbed natural gas (ANG) uses adsorbents and operates with a low storage pressure which results in lower capital costs and maintenance. This paper describes the production of an activated carbon adsorbent produced from an Illinois coal for ANG.
Breath-Synchronized Nebulized Surfactant in a Porcine Model of Acute Respiratory Distress Syndrome (2021)

Breath-synchronized, nebulized bovine surfactant appears to be a safe and feasible treatment option for use in coronavirus disease 2019 and other severe forms of acute respiratory distress syndrome.
Synthesis and Characterization of Axially Chiral Molecules Containing Dendritic Substituents (1998)

Enantiomerically pure, axially chiral (S)-1,1′-bi-2-naphthol has been used as a core material to which Fréchet-type dendritic wedges of the zeroth up to the fourth generation were attached, yielding the first axially chiral dendrimers 1−5. The chiroptical features of these compounds were studied and revealed an increasing molar optical activity for higher generations of dendrimers. This effect can be explained by a larger torsional angle between the naphthyl units, caused by steric repulsions between the dendritic wedges. However, the effect is marginal, indicating a high degree of flexibility present in the axially chiral dendrimers.
Spectroscopy and dynamics of resonance Raman scattering by iodobenzene excited in the B continuum (1992)

Resonance Raman scattering in iodobenzene is studied for excitation in the region 219–233 nm (B 1A1←X 1A1). There is a rich Raman spectrum containing strong fundamentals of ring-based modes and the CI stretch. On resonance, overtones and combination bands of most modes are strongly enhanced. The modulation of the CI stretch activity as a function of wavelength is interpreted in terms of the initial dynamical evolution of the molecule in the excited state. A normal mode analysis is also made of the ground-state planar modes of iodobenzene in order to correlate the observations with the resonance Raman spectra in benzene.
Supplementary Figure 2 from p53–Pirh2 Complex Promotes Twist1 Degradation and Inhibits EMT (2023)

&lt;p&gt;TP53 mutation status and protein levels of p53 and Twist1 ovarian cancer cell lines. * u = unknown.&lt;/p&gt;
Attainment of a high-quality electron beam for Fermilab's 4.3 MeV cooler (2005)

The recent demonstration of electron cooling of antiprotons in the Recycler ring required a stable 4.3 MeV electron beam with a DC current of hundreds of mA and an angular spread in the cooling section of a fraction of a mrad. This paper describes the achieved parameters of the Fermilab cooler's electron beam and details of operation.
Silicon layer transfer by hydrogen implantation combined with wafer bonding in ultrahigh vacuum (2006)

A layer transfer method was developed by combining in situ photothermal activation of hydrogen passivated surfaces, ultrahigh vacuum bonding, and hydrogen-implantation induced splitting. Structural and electrical investigations showed that ultrathin, single crystalline silicon layers can be transferred to appropriate substrates without the involvement of an intermediate layer such as an oxide or solder. Significant current flow across such produced silicon-silicon bonded interfaces was observed, making this approach very attractive for material integration.
Prävention und Therapie der Frühgeburt. Leitlinie der DGGG, OEGGG und SGGG (S2k-Niveau, AWMF-Registernummer 015/025, Februar 2019) – Teil 2 mit Empfehlungen zur tertiären Prävention der Frühgeburt und zum Management des frühen vorzeitigen Blasensprungs (2019)

Part 2 of this short version of the guideline presents Statements and Recommendations on the tertiary prevention of preterm birth and the management of preterm premature rupture of membranes.
Surgical Outcomes of 25-Gauge Transconjunctival Vitrectomy Combined With Cataract Surgery for Vitreoretinal Diseases (2006)

25-gauge vitrectomy combined with cataract surgery is a safe and effective system for the management of a variety of vitreoretinal diseases, especially cases requiring minimal intraocular manipulation. Further study is recommended to evaluate potential postoperative complications.
Three-year clinical effectiveness of four total-etch dentinal adhesive systems in cervical lesions. (1996)

A 3-year follow-up clinical trial of two experimental Bayer total-etch adhesive systems and two commercial total-etch systems. Clearfil Liner Bond System and Scotchbond Multi-Purpose, was conducted to evaluate their clinical effectiveness in Class V cervical lesions. Four hundred twenty abrasion-erosion lesions were restored randomly using the four adhesive systems. There were two experimental cavity designs, in which the adjacent enamel margins either were or were not beveled and acid etched. Clearfil Liner Bond System and Scotchbond Multi-Purpose demonstrated high retention rates in both types of cavity design at 3 years. The two experimental Bayer systems scored much lower retention rates in both cavity designs at 3 years. None of the systems guaranteed margins free of microleakage for a long time. At 3 years, superficial, localized marginal discolorations were observed, the least for Clearfil Liner Bond System, followed by Scotchbond Multi-Purpose and the two experimental systems. Small marginal defects were recorded at the cervical dentin and the incisal enamel margin. Retention of Clearfil Liner Bond and Scotchbond Multi-Purpose appears to be clearly improved over earlier systems, but marginal sealing remains problematic. The two Bayer systems were found to be clinically unreliable.
Numerical modeling of cross‐well seismic monopole sensor data (1992)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1992Numerical modeling of cross‐well seismic monopole sensor dataAuthors: A. L. KurkjianHenrik SchmidtThomas L. MarzettaJ. E. WhiteC. ChouzenouxA. L. KurkjianSchlumberger Cambridge Research, England, Henrik SchmidtM.I.T, Thomas L. MarzettaNichols Research Corp., J. E. WhiteColorado School of Mines, and C. ChouzenouxSchlumberger, Francehttps://doi.org/10.1190/1.1822022 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1822022FiguresReferencesRelatedDetailsCited ByElastic least-squares reverse time migrationZongcai Feng and Gerard T. Schuster16 February 2017 | GEOPHYSICS, Vol. 82, No. 2References16 June 2017Crosswell seismic waveguide phenomenology of reservoir sands & shales at offsets >600 m, Liaohe Oil Field, NE ChinaGeophysical Journal International, Vol. 163, No. 1Wave motion between two fluid-filled boreholes in an elastic mediumEngineering Analysis with Boundary Elements, Vol. 26, No. 2 SEG Technical Program Expanded Abstracts 1992ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1992 Pages: 1410 publication data© 1992 Copyright © 1992 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION A. L. Kurkjian, Henrik Schmidt, Thomas L. Marzetta, J. E. White, and C. Chouzenoux, (1992), "Numerical modeling of cross‐well seismic monopole sensor data," SEG Technical Program Expanded Abstracts : 141-144. https://doi.org/10.1190/1.1822022 Plain-Language Summary PDF DownloadLoading ...
Human monoclonal anti-idiotypic antibodies as an epitope vaccine against pancreatic carcinoma. (1988)

During therapeutic repetitive application of MAb BW 494 in pancreatic carcinoma patients, a human IgG anti MAb BW 494 response arose, which was analyzed on the B cell clonal level as well as in the serum of these patients 2-4 months after treatment. From 5 investigated patients 3 developed a polyclonal human IgG anti-idiotypic response in the serum and had B cells with the same specificity which could be immortalized by EBV transformation. Two out of 5 patients showed an anti-idiotypic and anti-isotypic polyclonal response which could be found on the B cell clonal level as well. The data indicated that the human IgG anti MAb BW 494 response was mainly anti-idiotypic.
Multiple polymerization – formation of hybrid materials consisting of two or more polymers from one monomer (2016)

The synthesis of hybrid materials consisting of three different components from only one monomer is reported for the first time.
Technique for testing the patency of laser iridotomies (1986)

With laser iridotomy it may often be difficult to achieve total penetration of the iris, particularly in very light or very dark irides. It may be impossible to determine with the slit-lamp whether a small laser iridotomy is functionally penetrating. We describe a straightforward method to test iridotomies for aqueous flow patency. Transcorneally introduced fluorescein is used to delineate any aqueous bulk flow from the posterior to the anterior chamber.
Modeling clicks beyond the first result page (2013)

Most modern web search engines yield a list of documents of a fixed length (usually 10) in response to a user query. The next ten search results are usually available in one click. These documents either replace the current result page or are appended to the end. Hence, in order to examine more documents than the first 10 the user needs to explicitly express her intention. Although clickthrough numbers are lower for documents on the second and later result pages, they still represent a noticeable amount of traffic.
A New Single-Photon Emission Computed Tomography Imaging Agent for Serotonin Transporters:  [123I]IDAM, 5-Iodo-2-((2-((dimethylamino)methyl)phenyl)thio)benzyl Alcohol (1999)

ADVERTISEMENT RETURN TO ISSUELetterNEXTA New Single-Photon Emission Computed Tomography Imaging Agent for Serotonin Transporters: [123I]IDAM, 5-Iodo-2-((2-((dimethylamino)methyl)phenyl)thio)benzyl AlcoholShunichi Oya, Mei-Ping Kung, Paul D. Acton, Mu, Catherine Hou, and Hank F. KungView Author Information Departments of Radiology and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 Cite this: J. Med. Chem. 1999, 42, 3, 333–335Publication Date (Web):January 27, 1999Publication History Received3 December 1998Published online27 January 1999Published inissue 1 February 1999https://pubs.acs.org/doi/10.1021/jm9806751https://doi.org/10.1021/jm9806751rapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views301Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Biological imaging,Central nervous system,Neurophysiology,Screening assays,Single photon emission computed tomography Get e-Alerts
ChemInform Abstract: Oxidative Cleavage of N,N‐Dialkylhydrazones to Ketones with Magnesium Monoperoxyphthalate. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Highly Reliable Piezoelectric Actuator for Precision Stage System (2005)

A highly reliable nonresonant ultrasonic motor (NRUSM) made of cylindrical piezoelectric material is proposed in this paper. The high reliability is characterized by long lifetime and no outer gas in the vacuum environment, which are ensured by not using stack adhesives as the source of the gas emission. Positioning and tracking accuracy was better than below ±2 nm. The structural design is discussed in terms of the application to a high-speed high-precision stage system which has stable response to frequent biases without interference from resonant phenomena and the required mechanical strength.
Effect of Conductance Variability on Resistor-Logic Demultiplexers for Nanoelectronics (2006)

On a mixed-scale nanoelectronic crossbar, in which nanowires cross CMOS-scale wires at right angles, a demultiplexer circuit may be laid out using configurable resistors at the crosspoint junctions. This circuit can function as an interface between conventional CMOS microelectronic circuitry and the smaller nanocircuitry by allowing a few CMOS address lines to control a much larger number of nanowires. The voltage margin properties of these resistor-demultiplexers can be improved by basing them on error-correcting codes. In any real fabrication process, the conductances of the resistors in the demultiplexer circuit will be distributed over a range of values. Using simulation, we investigate how variability in the conductances affects the voltages on the output lines of the demultiplexer, and the related voltage margin of the overall circuit. The simulation results provide a simple quantitative relationship revealing that the voltage variability is smaller than the component variability
Computer registration of radioactive indicator-dilution curves (1983)

A system is described for recording indicator-dilution curves produced by gamma radiation-emitting tracers. The system consists of a flow-through cuvette in a well counter, appropriate commercially available gamma radiation-detecting equipment, an Apple II computer, and a two-channel pulse-counting interface of our own design. With the counting interface and the software described here, an investigator can simultaneously record two indicator-dilution curves produced by gamma emitters. Instead of having to wait hours or days for results, the investigator can watch the data being recorded and display the results in graphic form almost immediately after each injection.
Algorithms for high-level synthesis: resource utilization-based approach (1992)

This thesis presents a new high level synthesis system, HYPER. HYPER uses a single, global quality measure, called the resource utilization measure, to drive the design space exploration process. This unique approach effectively merges the allocation, assignment, scheduling, transformations, and estimation with hierarchy handling in an unified manner.
Three HYPER parts are discussed: estimations, hierarchical graph allocation, assignment and scheduling and transformations. New transformation environment has been developed. Several new transformations (including retiming and associativity, software pipelining and software retiming, commutativity, and very fast implementation of recursive programs), based on a novel learning while searching and anti-voter rejectionless techniques, are introduced.
The effectiveness of the proposed algorithms is demonstrated in multiple ways: using standard benchmarks examples, with the aid of statistical analysis and through a comparison with estimated minimal bounds. Sharp minimal bounds based on a discrete relaxation technique are used.
Automated detection of retinal disease. (2014)

Nearly 4 in 10 Americans with diabetes currently fail to undergo recommended annual retinal exams, resulting in tens of thousands of cases of blindness that could have been prevented. Advances in automated retinal disease detection could greatly reduce the burden of labor-intensive dilated retinal examinations by ophthalmologists and optometrists and deliver diagnostic services at lower cost. As the current availability of ophthalmologists and optometrists is inadequate to screen all patients at risk every year, automated screening systems deployed in primary care settings and even in patients' homes could fill the current gap in supply. Expanding screens to all patients at risk by switching to automated detection systems would in turn yield significantly higher rates of detecting and treating diabetic retinopathy per dilated retinal examination. Fewer diabetic patients would develop complications such as blindness, while ophthalmologists could focus on more complex cases.
A 2 GHz down-converter with a 3 dB bandwidth of 600 MHz using LO signal suppressing output buffer (2002)

In recent years, wide-band wireless communication systems such as IMT-2000 for mobile communication and IEEE802.11 standard for W-LAN applications have received considerable attention. These wide-band systems use a channel bandwidth up to many tens of MHz to achieve a high bit-rate data transfer. In receiver front-end for such wide-band systems, a down-converter (D/C) is required to output a wide-band IF signal whose level should be significantly flat within its channel band for sufficient BER. A D/C and other function blocks are also required not to use many external components and additional pins for a highly integrated receiver. This paper describes a single-balanced Gilbert-cell type D/C with a small number of pins, which can output a wide-band IF signal converted from a 2-GHz-band RF signal.
Extreme Ultraviolet Phase Contrast Imaging (2005)

The conclusions of this report are: (1) zone plate microscopy provides high resolution imaging of EUV masks; (2) using phase plates in the back focal plane of the objective lens can provide contrast mechanisms for measurement of the phase shift from defects on the mask; (3) the first high resolution EUV Zernike phase contrast images have been acquired; and (4) future work will include phase contrast mode in reflection from an EUV mask to directly measure the reflectivity and phase shift from defects.
Polarization selectivity of gratings written in Hi-Bi fibers by the external method (1995)

Gratings have been written in a commercially available elliptical-core fiber using the transverse holographic method. Type I and II-A dynamics have been observed as being strongly anisotropic. As a result, the grating reflectivity can be made highly polarization dependent according to the experimental conditions of the inscription.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Air pollution and IgE sensitization in 4 European birth cohorts—the MeDALL project (2020)

Air pollution exposure does not seem to increase the overall risk of allergic sensitization; however, sensitization to birch as well as grass pollen Phl p 1 and cat Fel d 1 allergen molecules may be related to specific pollutants.
Beamforming maximizes the rank one Ricean MIMO compound capacity (2005)

In this paper, we consider the optimization of the compound capacity in a rank one Ricean multiple input multiple output channels using partial channel state information at the transmitter side. We model the channel as a deterministic matrix within a known ellipsoid, and maximize the compound capacity defined as the worst case capacity within this set. We find that the optimal transmit strategy is always beamforming, and can be found using a simple one dimensional search. These results motivate the growing use of systems using simple beamforming transmit strategies.
Basis Function Sampling: A New Paradigm for Material Property Computation (2014)

Wang-Landau sampling, and the associated class of flat histogram simulation methods have been remarkably helpful for calculations of the free energy in a wide variety of physical systems. Practically, convergence of these calculations to a target free energy surface is hampered by reliance on parameters which are unknown a priori. Here, we derive and implement a method built upon orthogonal functions which is fast, parameter-free, and (importantly) geometrically robust. The method is shown to be highly effective in achieving convergence. An important feature of this method is its ability to attain arbitrary levels of description for the free energy. It is thus ideally suited to in silico measurement of elastic moduli and other material properties related to free energy perturbations. We demonstrate the utility of such applications by applying our method to calculate the Frank elastic constants of the Lebwohl-Lasher model of liquid crystals.