gebhart/patrepeval huggingface dataset:
Evaluation of Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry for Rapid Detection of β-Lactam Resistance in Enterobacteriaceae Derived from Blood Cultures (2014)

The identification of pathogens directly from blood cultures by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) can be a valuable tool for improving the treatment of patients with sepsis and bacteremia. However, the increasing incidence of multidrug-resistant Gram-negative bacteria makes it difficult to predict resistance patterns based only on pathogen identification. Most therapy regimens for sepsis caused by Gram-negative rods consist of at least one β-lactam antibiotic. Thus, it would be of great benefit to have an early marker of resistance against these drugs. In the current study, we tested 100 consecutive blood cultures containing Enterobacteriaceae for resistance against 3rd-generation cephalosporins in a MALDI-TOF MS β-lactamase assay. Escherichia coli was also tested for resistance against aminopenicillins. The results of the β-lactamase assay were compared with those of conventional methods. The assay permitted discrimination between E. coli strains that were resistant or susceptible to aminopenicillins with a sensitivity and a specificity of 100%. The same was true for resistance to 3rd-generation cephalosporins in Enterobacteriaceae that constitutively produced class C β-lactamases. Discrimination was more difficult in species expressing class A β-lactamases, as these enzymes can generate false-positive results. Thus, the sensitivity and specificity for this group were 100% and 91.5%, respectively. The test permitted the prediction of resistance within 2.5 h after the blood culture was flagged as positive.
Anonymous Hierarchical Identity-Based Encryption (Without Random Oracles). (2006)

Abstract We present an identity-based cryptosystem that features fully anonymous ciphertexts andhierarchical key delegation. We give a proof of security in the standard model, based on the mild
Combinatorial methods: from groups to polynomial algebras (1997)

Combinatorial methods (or methods of elementary transformations) came to group theory from low-dimensional topology in the beginning of the century. Soon after that, combinatorial group theory became an independent area with its own powerful techniques. On the other hand, combinatorial commutative algebra emerged in the sixties, after Buchberger introduced what is now known as Gröbner bases. The purpose of this survey is to show how ideas from one of those areas contribute to the other.
Note-taking in co-located collaborative visual analytics: Analysis of an observational study (2012)

In an observational study, we noticed that record-keeping plays a critical role in the overall process of collaborative visual data analysis. Record-keeping involves recording material for later use, ranging from data about the visual analysis processes and visualization states to notes and annotations that externalize user insights, findings, and hypotheses. In our study, co-located teams worked on collaborative visual analytics tasks using large interactive wall and tabletop displays. Part of our findings is a collaborative data analysis framework that encompasses record-keeping as one of the main activities. In this paper, our primary focus is on note-taking activity. Based on our observations, we characterize notes according to their content, scope, and usage, and describe how they fit into a process of collaborative data analysis. We then discuss suggestions to improve the design of note-taking functionality for co-located collaborative visual analytics tools.
Histomorphological and torque removal comparison of 6 mm orthodontic miniscrews with and without surface treatment in New Zealand rabbits (2015)

SLA surface preparation does not increase the RTV of miniscrews. Further investigations under loading and a large sample size are required.
Prototype Robotic Masonry System (1993)

The introduction of robots and automation technology to construction operations will require considerable efforts to understand the mechanics of the many tasks better as they relate to building structures. To control arms, grippers, nozzles, and other production devices automatically, the mechanics of tools as they interact and work with the different construction materials requires extensive knowledge. One approach to learn about the behavior of all the components of an automated system for construction is to build scaled prototypes that are able to handle the actual material. This paper describes the design of an automated masonry system for prefabricating brick panels. It discusses the conditions that affect the bond strength of the masonry. It then describes the design and development of a Cartesian robot actuator and scaled‐down mortar spreader system built to test the bond strengths and accuracy of robotically placed bricks. The actual fabrication of the partially functional prototype helped the researchers to gain hands‐on familiarity with the many real‐world obstacles in using automation and robotics in construction. However, the learning experience also included an appreciation of the potentials offered by using advanced technologies in construction.
Optimized low-power synchronizer design for the IEEE 802.11a standard (2003)

The authors propose a low-power synchronizer design for the IEEE 802.11a standard capable to estimate frequency offsets in the range /spl plusmn/468 kHz (80 ppm @ 5.8 GHz) with very simple and effective frame detection and timing synchronization. The core area of the design after layout is 13 mm/sup 2/, including the CORDIC and FFT processors, with a total estimated power consumption of 140 mW.
GSH or Palmitate Preserves Mitochondrial Energetic/Redox Balance, Preventing Mechanical Dysfunction in Metabolically Challenged Myocytes/Hearts From Type 2 Diabetic Mice (2012)

In type 2 diabetes, hyperglycemia and increased sympathetic drive may alter mitochondria energetic/redox properties, decreasing the organelle's functionality. These perturbations may prompt or sustain basal low-cardiac performance and limited exercise capacity. Yet the precise steps involved in this mitochondrial failure remain elusive. Here, we have identified dysfunctional mitochondrial respiration with substrates of complex I, II, and IV and lowered thioredoxin-2/glutathione (GSH) pools as the main processes accounting for impaired state 4→3 energetic transition shown by mitochondria from hearts of type 2 diabetic db/db mice upon challenge with high glucose (HG) and the β-agonist isoproterenol (ISO). By mimicking clinically relevant conditions in type 2 diabetic patients, this regimen triggers a major overflow of reactive oxygen species (ROS) from mitochondria that directly perturbs cardiac electro-contraction coupling, ultimately leading to heart dysfunction. Exogenous GSH or, even more so, the fatty acid palmitate rescues basal and β-stimulated function in db/db myocyte/heart preparations exposed to HG/ISO. This occurs because both interventions provide the reducing equivalents necessary to counter mitochondrial ROS outburst and energetic failure. Thus, in the presence of poor glycemic control, the diabetic patient's inability to cope with increased cardiac work demand largely stems from mitochondrial redox/energetic disarrangements that mutually influence each other, leading to myocyte or whole-heart mechanical dysfunction.
Hierarchical‐Porous Ceramic Foams by a Combination of Replica and Freeze Technique (2019)

Open‐porous alumina foams with additional strut porosity are fabricated by a two‐step sponge‐replication based manufacturing process. As the first step, open cellular ceramic foams are prepared following the Schwarzwalder sponge replication technique. Therefore, organic foam templates are coated with different aqueous alumina slurries with a solid load between 20 and 40 vol% In a second step, an additional porosity is generated inside the foam struts by freezing of the foams at temperatures between −196 and −20 °C and subsequent sublimation drying. The hierarchical structure of both, cell pores and strut pores in the freeze‐dried material remains intact after drying, template removal, and sintering. Size, connectivity, and morphology of the strut pores strongly depend on the solid load of the alumina slurry and on the freezing temperature. Cellular structures with a strut porosity between 50% and 60% and a total porosity exceeding 90% are prepared, which show a compressive strength in between 0.4 to 0.6 MPa. Due to the additional strut porosity, the specific surface area of freeze‐dried replica foams increases from 70 cm 2 g −1 for conventionally prepared foams to 200 cm 2 g −1 for freeze‐dried foams, respectively.
Optimized Conformal Surface Registration with Shape-based Landmark Matching (2010)

Surface registration, which transforms different sets of surface data into one common reference space, is an important process which allows us to compare or integrate the surface data effectively. If a nonrigid transformation is required, surface registration is commonly done by parameterizing the surfaces onto a simple parameter domain, such as the unit square or sphere. In this work, we are interested in looking for meaningful registrations between surfaces through parameterizations, using prior features in the form of landmark curves on the surfaces. In particular, we generate optimized conformal parameterizations which match landmark curves exactly with shape-based correspondences between them. We propose a variational method to minimize a compound energy functional that measures the harmonic energy of the parameterization maps and the shape dissimilarity between mapped points on the landmark curves. The novelty is that the computed maps are guaranteed to align the landmark features consistently and give a shape-based diffeomorphism between the landmark curves. We achieve this by intrinsically modeling our search space of maps as flows of smooth vector fields that do not flow across the landmark curves. By using the local surface geometry on the curves to define a shape measure, we compute registrations that ensure consistent correspondences between anatomical features. We test our algorithm on synthetic surface data. An application of our model to medical imaging research is shown, using experiments on brain cortical surfaces, with anatomical (sulcal) landmarks delineated, which show that our computed maps give a shape-based alignment of the sulcal curves without significantly impairing conformality. This ensures correct averaging and comparison of data across subjects.
FACS analysis of a hyperthermia‐induced alteration in Hoechst 33342 permeability and direct measurement of its relationship to cell survival (1985)

Heat-induced alterations in CHO-10B cell Hoechst 33342 (Ho342) permeability in vitro were analyzed by flow cytometry. Immediately after 45.5 degrees C heating, uptake was decreased in a dose-dependent manner with cytotoxicity. Kinetic analysis indicated that a treatment that reduced cell survival to approximately 10%, reduced the maximal velocity, Vmax, to 53% of control and increased the dissociation constant, Km, to 156% of control. Also, little change in Ho342 efflux was found to occur from control up to 90 min after heating. Upon incubation at 37 degrees C after the heat treatment from 1 to 24 hr (depending on the severity of the dose) diffuse heterogeneity of Ho342 staining developed which was not evident immediately after heating. The altered staining was not due to the presence of trypan blue staining cells. Membrane permeabilization and nuclei isolation studies indicated that the lesion responsible was most likely a plasma membrane event. Induction of the heterogenous staining was not inhibited by either actinomycin D or hydroxyurea but was inhibited by incubation at 4 degrees C. An inverse correlation existed between Ho342 permeability and clonogenicity, with nearly a 10-fold difference in survival between the high and low fluorescence intensity sorted cells. Also, larger fractions of heat-sensitive S and G2M-phase cells were found in the highly fluorescent sorted fractions. These results are discussed in terms of the putative molecular events that may be involved in hyperthermic modulation of Ho342 permeability.
The fixed point iteration of positive concave mappings converges geometrically if a fixed point exists: implications to wireless systems (2021)

We prove that the fixed point iteration of arbitrary positive concave mappings with nonempty fixed point set converges geometrically for any starting point. We also show that positivity is crucial for this result to hold, and the concept of (nonlinear) spectral radius of asymptotic mappings provides us with information about the convergence factor. As a practical implication of the results shown here, we rigorously explain why some power control and load estimation algorithms in wireless networks, which are particular instances of the fixed point iteration, have shown geometric convergence in simulations. These algorithms have been typically derived by considering fixed point iterations of the general class of standard interference mappings, so the possibility of sublinear convergence rate could not be ruled out in previous studies, except in special cases that are often more restrictive than those considered here.
Crystalline and Optical Properties of ELO GaN by HVPE Using Tungsten Mask (2000)

The epitaxial lateral overgrowth (ELO) of GaN with a stripe tungsten (W) mask pattern is performed by hydride vapor phase epitaxy (HVPE) and the crystalline and optical properties are investigated compared with ELO GaN using SiO2 mask by characterizations of X-ray rocking curve (XRC), transmission electron microscopy (TEM) and low temperature cathodoluminescence (CL). A buried ELO structure of the W mask with a smooth surface is successfully obtained. The tilt of c-axis on the W mask in the ELO GaN is not observed, but in the case of the SiO2 mask, c-axis tilts on the mask region at 1 to 10◦ together with small angle grain boundaries. Half the way from the ELO interface to the surface, the luminescence becomes excitonic over the whole lateral extension region, which indicates the optically high crystalline quality of the material. On the other hand, different kinds of luminescence are observed depending on the position. The difference of these luminescence is caused by the defects and/or impurity incorporation on the mask region due to the tilting of c-axis. key words: epitaxial lateral overgrowth (ELO), tungsten mask,
Extracorporeal Life Support to Left Ventricular Assist Device Bridge to Heart Transplant (1999)

Background —The use of extracorporeal life support (extracorporeal membrane oxygenation [ECMO]) as a direct bridge to heart transplant in adult patients is associated with poor survival. Similarly, the use of an implantable left ventricular assist device (LVAD) to salvage patients with cardiac arrest, severe hemodynamic instability, and multiorgan failure results in poor outcome. The use of LVAD implant in patients who present with cardiogenic shock who have not been evaluated for transplantation or who have sustained a recent myocardial infarction also raises concerns. ECMO may provide reasonable short-term support to patients with severe hemodynamic instability, permit recovery of multiorgan injury, and allow time to complete a transplant evaluation before long-term circulatory support with an implantable LVAD is instituted. After acquisition of the HeartMate LVAD (Thermo Cardiosystems, Inc), we began using ECMO as a bridge to an implantable LVAD and, subsequently, to transplantation in selected high-risk patients. Methods and Results —From October 1, 1996, through September 30, 1998, 32 adult patients who presented with refractory cardiogenic shock (cardiac index &lt;2.0 L · min −1 · m −2 , with systolic blood pressure &lt;100 mm Hg and pulmonary capillary wedge pressure ≥24 mm Hg and dependent on ≥2 inotropes with or without intra-aortic balloon pump) were evaluated and accepted as candidates for mechanical assistance as a bridge to transplant. Of the 32 patients, 14 (group I) had a cardiac arrest or severe hemodynamic instability (systolic blood pressure ≤75 mm Hg) with evidence of multiorgan failure (defined as serum creatinine level &gt;3 mg/dL or oliguria; international normalized ratio &gt;1.5 or transaminases &gt;5 times normal or total bilirubin &gt;3 mg/dL; and needing mechanical ventilation). Group I patients were placed on ECMO support; 7 underwent subsequent LVAD implant and 1 was bridged directly to transplant. Six patients in group I survived to transplant hospitalization discharge. The remaining 18 patients (group II) underwent LVAD implant without ECMO support; 12 survived to transplant hospitalization discharge and 2 remained alive with ongoing LVAD support and awaited transplant. One-year actuarial survival from the initiation of circulatory support was 43% in group I and 75% in group II. One-year actuarial survival from the time of LVAD implant in group I, conditional on surviving ECMO, was 71% ( P =NS compared with group II). Conclusions —In appropriately selected high-risk patients, the rate of LVAD survival after initial ECMO support was not significantly different from the survival rate after LVAD support alone. An initial period of resuscitation with ECMO is an effective strategy to salvage patients with extreme hemodynamic instability and multiorgan injury. Use of LVAD resources is improved by avoiding LVAD implant in a very-high-risk cohort of patients who do not survive ECMO.
First cation radical mixed-valence hybrid salts of the paramagnetic octahedral cluster Nb6Cl183–. Preparation, crystal structures, and conducting and magnetic properties of pentakis(2,3,6,7-tetramethyl-1,4,5,8-tetra-selena- and -thia-fulvalenium) hexachloro(dodeca-µ2-chloro-octahedro-hexaniobate) (1987)

Electrically conducting single crystals of (D)5Nb6Cl18(CH2Cl2)0.5[D = 2,3,6,7-tetramethyl-1,4,5,8-tetra-selena- and -thia-fulvalene (TMTTF) and (TMTTF) in (1) and (2) respectively] have been grown electrochemically; their unique crystal structure shows a one-dimensional stack with a periodicity twice that of the Bechgaard salts; the observed Curie–Weiss behaviour of the magnetic susceptibility demonstrates the presence of one non-interacting spin per unit-cell; this is not purely a cluster spin as indicated by e.s.r. spectroscopy.
Impact of Diabetes Among Revascularized Patients in Japan and the U.S. (2012)

Although diabetes was less prevalent in U.S. patients than in Japanese patients, U.S. patients had higher overall long-term mortality risk. This difference was more pronounced in diabetic patients.
N,N′-Dibromo-5,5-dimethylhydantoin andN-Bromosuccinimide, Chemical Sources of Singlet Molecular Oxygen: Observation of Singlet Oxygen with Ultra-sensitive Near-infrared Chemiluminescence Spectroscopy (1990)

Journal Article N,N′-Dibromo-5,5-dimethylhydantoin and N-Bromosuccinimide, Chemical Sources of Singlet Molecular Oxygen: Observation of Singlet Oxygen with Ultra-sensitive Near-infrared Chemiluminescence Spectroscopy Get access Nobutaka Suzuki, Nobutaka Suzuki Biophoton Project, Research Development Corporation of Japan (JRDC), Miyagino, Sendai 980, Japan To whom correspondence should be addressed. Search for other works by this author on: Oxford Academic Google Scholar Atsushi Takahashi, Atsushi Takahashi Biophoton Project, Research Development Corporation of Japan (JRDC), Miyagino, Sendai 980, Japan Search for other works by this author on: Oxford Academic Google Scholar Shinro Mashiko, Shinro Mashiko Biophoton Project, Research Development Corporation of Japan (JRDC), Miyagino, Sendai 980, Japan Present address: Communications Research Laboratory, Ministry of Posts and Telecommunications, Koganei, Tokyo 184, Japan. Search for other works by this author on: Oxford Academic Google Scholar Iwao Mizumoto, Iwao Mizumoto Research Institute of Electrical Communication, Tohoku University, Aoba, Sendai 980, Japan Search for other works by this author on: Oxford Academic Google Scholar Humio Inaba Humio Inaba Biophoton Project, Research Development Corporation of Japan (JRDC), Miyagino, Sendai 980, JapanResearch Institute of Electrical Communication, Tohoku University, Aoba, Sendai 980, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 54, Issue 2, 1 February 1990, Pages 459–462, https://doi.org/10.1080/00021369.1990.10869936 Published: 01 February 1990 Article history Received: 11 August 1989 Published: 01 February 1990
Nanolithography of cylinder forming block copolymers via DSA for semiconductor manufacturing (2017)

To realize the full benefit of directed self-assembly (DSA), it is necessary to understand the interplay between the target structures and the process parameters.
An Update from Flatland (2016)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTAn Update from FlatlandAndrew T. S. Wee, Mark C. Hersam, Manish Chhowalla, and Yury GogotsiCite this: ACS Nano 2016, 10, 9, 8121–8123Publication Date (Web):September 27, 2016Publication History Published online27 September 2016Published inissue 27 September 2016https://pubs.acs.org/doi/10.1021/acsnano.6b06087https://doi.org/10.1021/acsnano.6b06087editorialACS PublicationsCopyright © 2016 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views3180Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (3 MB) Get e-AlertscloseSUBJECTS:Genomics,Heterostructures,Two dimensional materials Get e-Alerts
Chemoinformatics in Lead Discovery (2005)

This chapter contains sections titled: Chemoinformatics in the Context of Pharmaceutical Research Leads in the Drug Discovery Paradigm Is There a Trend for High Activity Molecules? The Concept of Leadlikeness Conclusions
In Vivo Anisotropic Mechanical Properties of Dystrophic Skeletal Muscles Measured by Anisotropic MR Elastographic Imaging: The mdx Mouse Model of Muscular Dystrophy (2014)

The mechanical anisotropic ratio of the shear storage moduli measured by an anisotropic MR elastographic technique can distinguish between healthy muscle and dystrophic muscle.