gebhart/patrepeval huggingface dataset:
Customer requirements on teleservice management (1995)

This paper examines some of the issues arising from customer requirements concerning the management of end-to-end services and guaranteed end-to-end quality of service. The implications of supporting the desired management capabilities both horizontally (inter-domain cooperative management) and vertically (from the service to the network elements) are discussed using as examples work currently being undertaken in two complementary projects.
Enzymatic Cyclisation of Peptides with a Transglutaminase (2010)

The ability of microbial transglutaminase to ligate two polypeptides through glutamine and lysine residues was exploited to generate cyclic peptides. Peptides with an N-terminal short glutamine-donor sequence (Ala-Leu-Gln), a variable polypeptide linker and a C-terminal lysine residue could efficiently be cyclised by the enzyme. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Effect of vaccination with a modified live porcine reproductive and respiratory syndrome virus vaccine on growth performance in fattening pigs under field conditions (2016)

Porcine reproductive and respiratory syndrome virus (PRRSV) has caused significant economic losses to the global swine industry. The present study aimed to evaluate the efficacy of a commercial PRRSV modified live virus (MLV) vaccine in conventionally reared growing/finishing pigs. Four barns were designated for groups A, B, C and D in the growing-to-finishing site. All pigs of the A barn were vaccinated with a commercial PRRSV MLV vaccine, whereas pigs of the B, C or D barn as control groups were unvaccinated. Twenty pigs randomly selected and tagged from each barn were serially bled at 0, 20, 40 and 60 day-post-vaccination, and tested for serological response with a commercial enzyme-linked immunosorbent assay kit. Body weights were measured to calculate the average-daily-weight gain (ADG). Serological assays indicated that the seropositivity of the PRRSV-vaccinated group was higher than that of the unvaccinated groups at 40 day-post-vaccination. ADG of group A was significantly higher than that of groups B and C, and the mean weights of groups A, B, C and D were 0.82 ± 0.017, 0.76 ± 0.016, 0.74 ± 0.019 and 0.81 ± 0.018 kg, respectively. In conclusion, the present study reports the serological responses and growth performance parameters by the PRRSV MLV vaccine in growing/finishing pigs under field conditions.
Graft-Versus-Leukemia Antigen CML66 Elicits Coordinated B And T Cell Immunity After Donor Lymphocyte Infusion (2010)

Donor lymphocyte infusion (DLI) is a highly effective treatment for relapsed chronic myeloid leukemia (CML) after allogeneic hematopoietic stem cell transplantation (HSCT), in which 70-80% patients achieve curative responses. Despite its clinical efficacy, the mechanism by which DLI achieves anti-tumor immunity remains incompletely understood. CML66 is a CML-associated antigen that is preferentially expressed in myeloid progenitor cells. CML66 elicited a potent antibody response in a patient with CML who achieved complete molecular remission following CD4+DLI in the absence of graft-versus-host disease. Since CD4+T cell responses often generate both antigen-specific antibody and CD8+T cell responses, we queried whether anti-CML66 antibodies were associated with the development of cytolytic T cell immunity against the same protein. CML66-reactive T cell clones were detected and found to be directed against a naturally processed and presented HLA-B∗4403-restricted epitope (HDVDALLW). This T cell epitope (at residues 459-467) is positioned in a different region of the protein compared to the B cell epitope (at residues 198-217: GFYVSLEWVTISKKNQDNK). Neither antibody nor T cell responses to CML66 were detectable in peripheral blood prior to DLI, by ELISA or ELISpot assays, respectively. However, starting as early as one month after DLI, CD8+T cells and then high-titer plasma antibody to CML66 were readily detected in peripheral blood, in close temporal correlation with disease remission. Examination of marrow by ELISpot 1 month after DLI revealed a 10 fold increased frequency of CML66-reactive CD8+T cells compared to peripheral blood. The CML66-reactive T cell clone could be also detected at low levels in vivo in patient marrow prior to DLI by ELISpot and nested PCR, in association with progressive leukemic relapse, but not in peripheral blood pre-DLI, nor in peripheral blood of the stem cell donor. These results suggest that marrow is a reservoir of donor T cells primed against patient leukemia following HSCT. Infusion of CD4+ donor T cells appears to result in the rapid expansion of pre-existing marrow-resident leukemia-specific CD8+T cells, followed by a cascade of antigen-specific immune responses detectable in the periphery. Our detailed analysis of this single antigen demonstrates that both B and T cell immunity contribute to effective tumor immunity that is directed at least in part to nonpolymorphic overexpressed leukemia antigens.
A dual-VDD boosted pulsed bus technique for low power and low leakage operation (2006)

In this paper, we propose a new dual-VDD bus technique that is well suited for low power operation. This technique adapts a static pulsed bus architecture to use dual-VDD power supplies. During quiescent periods, the bus system idles at the lower of the two VDD supplies, thereby lowering static power dissipation. When actively transitioning, the inverters in the bus system are temporarily boosted to the higher VDD supply to provide the needed drive strength for performance. Since the VDD boosting is done in a pulsed manner, the bus system is in a high VDD state only when required, ensuring lower power operation without sacrificing performance. This technique yields up to a 50% reduction in total power over traditional static buses and up to a 35% reduction in total power over standard static pulsed buses, with a 12-15% delay improvement.
A Low Power, Tight Seal, Polyimide Electrostatic Microvalve (1996)

Abstract An electrostatically-actuated polyimide microvalve with low power consumption (&amp;lt; 1mW) is presented in this paper. Bias voltage applied across a sub-micron gap between the sealing electrodes generates a large electrostatic force (1.3N) resulting in a tight seal for the valve. Built-in residual stress results in a curled bimorph cantilever which allows for a microactuator with large displacement. This microactuator is used to open and close a fluid path hole etched in silicon for a microvalve. The microactuator can be actuated with 25V for a displacement of 200 μm. The cantilever actuator is mainly composed of polyimide, which is flexible enough to conform over the flow hole, thereby eliminating the need for the design of a valve seat.
Alemtuzumab for patients with chronic lymphocytic leukaemia (2012)

In summary, the currently available evidence suggests an OS, CRR and PFS benefit for alemtuzumab compared with no further therapy, but an increased risk for infections in general, CMV infections and CMV reactivations. The role of alemtuzumab versus rituximab still remains unclear, further trials with longer follow-up and overall survival as primary endpoint are needed to evaluate the effects of both agents compared with each other. Alemtuzumab compared with chlorambucil seems to be favourable in terms of PFS, but a longer follow-up period and trials with overall survival as primary endpoint are needed to determine whether this effect will translate into a survival advantage.
Illusory reversal of action and sensation elicits neural conflict response (2005)

After participants adapted to a delay between their keypress and a flash, they experienced the illusory perception the flashes appearing at shorter delays preceded their keypress. When participants perceived these illusory reversals, BOLD signal increased in the dorsal anterior cingulate cortex, as compared to trials in which the participants perceived the veridical timing. This activation suggests conflict between two timing representation in the brain - one which adapts to the delay between action and effect, and one which does not. Other areas activated in this task - including the insula, inferior frontal gyrus and supramarginal gyrus - may be locations involved in time perception. We show that these areas may relate to a new psychophysical finding: humans have poor interval determination between action and effect up to 120 ms after they perform an action. That is, although motor-sensory intervals were judged accurately if the flash came from −200 to 0 ms before their keypress, interval determination of a flash from 0 to 120 ms after their keypress was impaired: all intervals in this region were reported to be close to 0 ms. The onset and offset of this 120 ms period could be shifted by adapting participants to a frequent 100 ms delay between their keypress and a flash. Collectively, these results indicate a plastic mechanism by which organisms can quickly recalibrate motor-sensory timing.
Five year outcomes of the subcutaneous implantable cardioverter-defibrillator EFFORTLESS (evaluation of factors impacting clinical outcome and cost effectiveness of the S-ICD) registry (2021)

Abstract Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): Boston Scientific OnBehalf EFFORTLESS Registry Introduction Patients (pts) implanted with transvenous (TV) implantable cardioverter-defibrillator (ICD) experience complications (Cx) associated with TV leads and inappropriate shocks (IAS) for atrial fibrillation (AF) or other supraventricular tachycardias (SVT). The EFFORTLESS S-ICD Registry is a 5-year (yr) follow-up (f/u) study of pts implanted with the subcutaneous ICD (S-ICD). Purpose To report on the 5-yr outcomes of pts with a wide range of S-ICD indications implanted with early generation devices. Methods Pts were enrolled at 43 centers February 2011-December 2014. Kaplan-Meier Cx, appropriate shock (AS), and IAS rates are reported. Results 994 pts (495 retrospective) were enrolled in the EFFORTLESS study and 984 pts (28% female, 48 ± 17 yrs, BMI 27 ± 6 kg/m2, ejection fraction 43 ± 18%) underwent S-ICD implantation. Mean study f/u was 4.4 ± 1.6 yrs. The pt cohort had diverse etiologies: 31% ischemic heart disease, 19% non-ischemic cardiomyopathy, 11% hypertrophic cardiomyopathy, 17% channelopathies, and 20% of pts miscellaneous. Total system- and procedure-related Cx (table) were 9.4% at 5 yrs. AS and IAS rates at 5 yrs were 15.9% and 16.9%, respectively and the IAS rates for AF/SVT and t wave oversensing were 3.1% and 5.8%, respectively. More pts experienced Cx and IAS in the first yr than in yrs 2-5 altogether (8.7 vs 8.2%), the most common as a result of discomfort/erosion (38%), IAS (26%), system infection (9%), and premature battery depletion (9%). Of these late Cx, 74% were experienced by retrospective pts. Spontaneous conversion efficacy for the first shock and final shocks was 89.7% and 97.7%. Of the 91 (9.2%) deaths reported, none were associated with the S-ICD system or procedure. Cause of death was cardiac for 40 pts, non-cardiac for 40 pts, other for 4 pts, and unknown for 7 pts. Only 20 (2.0%) pts had their S-ICD replaced for a TV device for pacing: 4 bradycardia, 7 anti-tachycardia, and 9 for biventricular pacing. Conclusions The EFFORTLESS registry provides 5-year follow-up for a diverse, large, multinational S-ICD registry. Complications primarily occurred in the first year but remained low through 5 years. Inappropriate shock rates were typically observed in older generation devices prior to introduction of the SMART Pass filter. Replacement for TV-ICD due to the need for pacing was rare. Outcome 30 day 1 yr 2 yr 3 yr 4 yr 5yr Annual Complications (Kaplan-Meier) 2.0 5.3 6.8 7.6 8.6 9.4 1.9 IAS, overall (Kaplan-Meier) 1.7 8.7 11.6 13.1 14.6 16.9 3.4 IAS, t wave oversensing 3.4 5.8 1.2
Fuel Economy Potential of Variable Compression Ratio for Light Duty Vehicles (2017)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Increasing compression ratio (CR) is one of the most fundamental ways to improve engine efficiency, but the CR of practical spark ignition engines is limited by knock and spark retard at high loads. A variable CR mechanism could improve efficiency by using higher CR at low loads, and lower CR (with less spark retard) at high loads.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;This paper quantifies the potential efficiency benefits of applying variable CR to a modern downsized, boosted gasoline engine. Load sweeps were conducted experimentally on a multi-cylinder gasoline turbocharged direct injection (GTDI) engine at several CRs.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;Experimental results were compared to efficiency versus CR correlations from the literature and were used to estimate the fuel economy benefits of 2-step and continuously variable CR concepts on several engine/vehicle combinations, for various drive cycles.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;For vehicles with automatic transmissions, the fuel economy benefit of 2-step variable CR was estimated to be 2.5-3.1% on the EPA Metro-Highway cycle, and 0.8-1.2% on the US06 cycle relative to a fixed 10:1 CR baseline. The benefit of continuously variable CR for the same vehicles was estimated to be 2.7-3.3% EPA Metro-Highway, and 1.7-2.1% US06. The effects of CR on exhaust gas temperature, peak cylinder pressure, burn rate, low-speed torque, and high-speed power were also examined.&lt;/div&gt;&lt;/div&gt;
(−)-Gallocatechin gallate from green tea rescues cognitive impairment through restoring hippocampal silent synapses in post-menopausal depression (2021)

Abstract Post-menopausal depression (PMD) is a common psychological disorder accompanied by a cognitive deficit, which is caused by a series of uncontrolled emotional disruptions by strong environmental stressors during menopause. To overcome PMD-induced cognitive deficit, Green tea has been suggested as a dietary supplement because of its ameliorating effect on cognitive dysfunction induced by normal aging or neurodegenerative syndromes; however, its clinical use to improve PMD-accompanied cognitive deficit is still limited due to the controversy for the active ingredients and ambiguous mechanism of its action. Here, we developed modified high-temperature-processed green tea extract (HTP-GTE), which showed lower neuronal toxicity than the conventional green tea extract (GTE). We also demonstrated that HTP-GTE administration prevented the development of learned helplessness (LH) in a rat post-menopausal model. Additionally, HTP-GTE improved LH-induced cognitive impairments simultaneously with rescued the long-term synaptic plasticity. This occurred via the restoration of silent synapse formation by increasing the hippocampal BDNF-tyrosine receptor kinase B pathway in the helpless ovariectomized (OVX) rats. Likewise, we also identified that (−)-gallocatechin gallate was the main contributor of the HTP-GTE effect. Our findings suggested that HTP-GTE has a potential as a preventive nutritional supplement to ameliorate cognitive dysfunctions associated with PMD.
Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets (2021)

Together, these results suggest that several candidate genes and pathways are associated with the findings observed in PD GWAS studies.
A quantum-limited CMOS-sensor-based high-speed imaging system for time-resolved x-ray scattering (2009)

The field of ultrafast x-ray science is flourishing, driven by emerging synchrotron sources (e.g., time-slice storage rings, energy recovery linacs, free electron lasers) capable of fine time resolution. New hybrid x-ray detectors are under development in order to exploit these new capabilities. This paper describes the development of a 2160 x 2560 CMOS image sensor (CIS) system with a 6.5 µm pitch optimized for time-resolved x-ray scattering studies. The system is single photon quantum limited from 8 keV to 20 keV. It has a wide dynamic range and can operate at 100 Hz full-frame and at higher frequencies using a region-of-interest (ROI) readout. Fundamental metrics of linearity, dynamic range, spatial resolution, conversion gain, sensitivity and Detective Quantum Efficiency are estimated. Experimental time-resolved data are also presented.
SARS–CoV-2 Immuno-Pathogenesis and Potential for Diverse Vaccines and Therapies: Opportunities and Challenges (2021)

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a novel coronavirus that emerged from Wuhan, China in late 2019 causing coronavirus disease-19 (COVID-19). SARS-CoV-2 infection begins by attaching to angiotensin-converting enzyme 2 receptor (ACE2) via the spike glycoprotein, followed by cleavage by TMPRSS2, revealing the viral fusion domain. Other presumptive receptors for SARS-CoV-2 attachment include CD147, neuropilin-1 (NRP1), and Myeloid C-lectin like receptor (CLR), each of which might play a role in the systemic viral spread. The pathology of SARS-CoV-2 infection ranges from asymptomatic to severe acute respiratory distress syndrome, often displaying a cytokine storm syndrome, which can be life-threatening. Despite progress made, the detailed mechanisms underlying SARS-CoV-2 interaction with the host immune system remain unclear and are an area of very active research. The process's key players include viral non-structural proteins and open reading frame products, which have been implicated in immune antagonism. The dysregulation of the innate immune system results in reduced adaptive immune responses characterized by rapidly diminishing antibody titers. Several treatment options for COVID-19 are emerging, with immunotherapies, peptide therapies, and nucleic acid vaccines showing promise. This review discusses the advances in the immunopathology of SARS-CoV-2, vaccines and therapies under investigation to counter the effects of this virus, as well as viral variants.
Leuhistin, a new inhibitor of aminopeptidase M, produced by Bacillus laterosporus BMI156-14F1. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. (1991)

Leuhistin has been isolated from the culture broth of Bacillus laterosporus BMI156-14F1 as part of a program designed to find microorganism-produced inhibitors of aminopeptidase M (AP-M). It was purified by use of column chromatography on Sepabeads SP206, Amberlite IRC-50, MCI gel CHP-20P and Sephadex G-10 and then isolated as colorless needles. Leuhistin inhibits AP-M strongly and it also inhibits AP-A and AP-B weakly. It is competitive with the substrate, and the inhibition constant (Ki) was 2.3 x 10(-7) M.
Ultrafast Gap Dynamics and Electronic Interactions in a Photoexcited Cuprate Superconductor (2017)

New investigations of a type of high-temperature superconductor using time- and angle-resolved photoemission spectroscopy reveal new details about the nature of photoexcitation and its relation to superconductivity.
Design and Sensing Properties of a Self‐Assembled Supramolecular Oligomer (2015)

Supramolecular polymers are a class of macromolecules stabilized by weak non-covalent interactions. These self-assembled aggregates typically undergo stimuli-induced reversible assembly and disassembly. They thus hold great promise as so-called functional materials. In this work, we present the design, synthesis, and responsive behavior of a short supramolecular oligomeric system based on two hetero-complementary subunits. These "monomers" consist of a tetrathiafulvalene-functionalized calix[4]pyrrole (TTF-C[4]P) and a glycol diester-linked bis-2,5,7-trinitrodicyanomethylenefluorene-4-carboxylate (TNDCF), respectively. We show that when mixed in organic solvents, such as CHCl<sub>3</sub> , CH<sub>2</sub> ClCH<sub>2</sub> Cl, and methylcyclohexane, supramolecular aggregation takes place to produce short oligomers stabilized by hydrogen bonding and donor-acceptor charge-transfer (CT) interactions. The self-associated materials were characterized by <sup>1</sup> H NMR and UV/Vis/NIR absorption spectroscopy, as well as by concentration- and temperature-dependent absorption spectroscopy and dynamic light scattering (DLS) analyses of both the monomeric and oligomerized species. The self-associated system produced from TTF-C[4]P and TNDCF exhibits a concentration-dependent aggregation behavior typical of supramolecular polymers. Further support for the proposed self-assembly came from theoretical calculations. The fluorescence emitting properties of TNDCF are quenched under conditions that promote the formation of supramolecular aggregates containing TTF-C[4]P and TNDCF. This quenching effect has been utilized as a probe for the detection of substrates in the form of anions (i.e., chloride) and nitroaromatic explosives (i.e., 1,3,5-trinitrobenzene). Specifically, the addition of these substrates to mixtures of TTF-C[4]P and TNDCF produced a fluorescence "turn-on" response.
Experience with an efficient parallel kernel memory allocator (2001)

Abstract There has been great progress from the traditional allocation algorithms designed for small memories to more modern algorithms exemplified by McKusick's and Karels' allocator (McKusick MK, Karels MJ. Design of a general purpose memory allocator for the 4.3BSD UNIX kernel. In USENIX Conference Proceedings , Berkeley, CA, June 1988). Nonetheless, none of these algorithms have been designed to meet the needs of UNIX kernels supporting commercial data‐processing applications in a shared‐memory multiprocessor environment. On a shared‐memory multiprocessor, memory is a global resource. Therefore, allocator performance depends on synchronization primitives and manipulation of shared data as well as on raw CPU speed. Synchronization primitives and access to shared data depend on system bus interactions. The speed of system buses has not kept pace with that of CPUs, as witnessed by the ever‐larger caches found on recent systems. Thus, the performance of synchronization primitives and of memory allocators that use them have not received the full benefit of increased CPU performance. An earlier paper (McKenney PE, Slingwine J. Efficient kernel memory allocation on shared‐memory multiprocessors. In USENIX Conference Proceedings , Berkeley, CA, February 1993), describes an allocator designed to meet this situation. This article reviews the motivation for and design of the allocator and presents the experience gained during the seven years that the allocator has been in production use. Copyright © 2001 John Wiley &amp; Sons, Ltd.
Co-located group interaction design (2008)

This design theatre experience explores the use of choreographic improvisation exercises to reflect on the structures of interaction in a mobile, co-located group. The design technique is motivated by studies of clinical ward rounds, and applies analytic models from Kendon, Garfinkel and Hutchins.