gebhart/patrepeval huggingface dataset:
A Stable Nanostructured Li-Deficient Oxide Thin-Film Electrode for Advanced Lithium-Ion Batteries (2015)

Recently, lithium-ion batteries have been used heavily in consumer electronics worldwide, and their use is expanding to electric vehicles and other high power transportation applications as their prices continue to decline. However, one of the main issues for the transportation application is the need to develop high-performance cathode materials. Here we report a novel nanostructured cathode material based on air-stable Li-deficient oxide thin film (Li 0.28 Co 0.29 Ni 0.30 Mn 0.20 O 2 ) for high-energy density lithium-ion batteries. This film is preparedvia a method combining radio frequency magnetron sputtering and in-situ post-annealingusing a crystalline and stoichiometric LiCo 1/3 Ni 1/3 Mn 1/3 O 2 target. ThisLi-deficient oxide thin film has a polycrystallinenanostructure, high tap density, and higher energy and power densitiescompared to the initial stoichiometric LiCo 1/3 Ni 1/3 Mn 1/3 O 2 . It surprisingly delivers large reversible capacity (216 mA h g −1 ), good cycle performance and superior rate capability. Such a materialis a promising cathode candidate for high-energy lithium-ion batteries,especially thin-film batteries.
Defect and Interfacial Structure of Heteroepitaxial Fe3O4/BaTiO3 Bilayers (2010)

The defect and interfacial structure in a Fe3O4/BaTiO3 heteroepitaxial bilayer was investigated by scanning transmission electron microscopy. The results show that the Fe3O4 film grew epitaxially on BaTiO3. The orientation relationship between Fe3O4, BaTiO3 and MgO is [100]Fe3O4//[100]BaTi3O//[100]MgO and (010)Fe3O4//(010)BaTiO3//(010)MgO. An initial interfacial nucleation layer was formed that partially accommodated the lattice mismatch strain between BaTiO3 and MgO. This investigation indicates that the formation of this buffer layer provides a high-quality BaTiO3 surface for subsequent Fe3O4 growth, resulting in a semicoherent interface. The Fe3O4 surface is nearly atomically abrupt (roughness Rrms = 0.78 nm). The Fe3O4 film exhibits magnetic domains with a diameter in the range of 0.4-2 microm.
Plasma membrane calcium ATPase deficiency causes neuronal pathology in the spinal cord: a potential mechanism for neurodegeneration in multiple sclerosis and spinal cord injury (2004)

Dysfunction and death of spinal cord neurons are critical determinants of neurological deficits in various pathological conditions, including multiple sclerosis (MS) and spinal cord injury. Yet, the molecular mechanisms underlying neuronal/axonal damage remain undefined. Our previous studies raised the possibility that a decrease in the levels of plasma membrane calcium ATPase isoform 2 (PMCA2), a major pump extruding calcium from neurons, promotes neuronal pathology in the spinal cord during experimental autoimmune encephalomyelitis (EAE), an animal model of MS, and after spinal cord trauma. However, the causal relationship between alterations in PMCA2 levels and neuronal injury was not well established. We now report that inhibition of PMCA activity in purified spinal cord neuronal cultures delays calcium clearance, increases the number of nonphosphorylated neurofilament H (SMI-32) immunoreactive cells, and induces swelling and beading of SMI-32-positive neurites. These changes are followed by activation of caspase-3 and neuronal loss. Importantly, the number of spinal cord motor neurons is significantly decreased in PMCA2-deficient mice and the deafwaddler(2J), a mouse with a functionally null mutation in the PMCA2 gene. Our findings suggest that a reduction in PMCA2 level or activity leading to delays in calcium clearance may cause neuronal damage and loss in the spinal cord.
Geometric discretization of nonholonomic systems with symmetries (2009)

The paper develops discretization schemes for mechanical systems for integration and optimization purposes through a discrete geometric approach. We focus on systems with symmetries, controllable shape (internal variables), and nonholonomic constraints. Motivated by the abundance of important models from science and engineering with such properties, we propose numerical methods specifically designed to account for their special geometric structure. At the core of the formulation lies a discrete variational principle that respects the structure of the state space and provides a framework for constructing accurate and numerically stable integrators. The dynamics of the systems we study is derived by vertical and horizontal splitting of the variational principle with respect to a nonholonomic connection that encodes the kinematic constraints and symmetries. We formulate a discrete analog of this principle by evaluating the Lagrangian and the connection at selected points along a discretized trajectory and derive discrete momentum equation and discrete reduced Euler-Lagrange equations resulting from the splitting of this principle. A family of nonholonomic integrators that are general, yet simple and easy to implement, are then obtained and applied to two examples-the steered robotic car and the snakeboard. Their numerical advantages are confirmed through comparisons with standard methods.
Protein Identification by MALDI-TOF-MS Peptide Mapping:  A New Strategy (2002)

A new strategy for identifying proteins by MALDI-TOF-MS peptide mapping is reported. In contrast to current approaches, the strategy does not rely on a good relative or absolute mass accuracy as the criterion that discriminates false positive results. The protein sequence database is first searched for all proteins that match a minimum five of the submitted masses within the maximum expected relative errors when the default or externally determined calibration constants are used, for instance, +/-500 ppm. Typically, this search retrieves many thousand candidate sequences. Assuming initially that each of these is the correct protein, the relative errors of the matching peptide masses are calculated for each candidate sequence. Linear regression analysis is then performed of the calculated relative errors as a function of m/z for each candidate sequence, and the standard deviation to the regression is used to distinguish the correct sequence among the candidates. We show that this parameter is independent of whether the mass spectrometric data were internally or externally calibrated. The result is a search engine that renders internal spectrum calibration unnecessary and adapts to the quality of the raw data without user interference. This is made possible by a dynamic scoring algorithm, which takes into account the number of matching peptide masses, the percentage of the protein's sequence covered by these peptides and, as new parameter, the determined standard deviation. The lower the standard deviation, the less cleavage peptides are required for identification and vice versa. Performance of the new strategy is demonstrated and discussed. All necessary computing has been implemented in a computer program, free access to which is provided in the Internet.
Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension (2011)

The heritable form of pulmonary arterial hypertension (PAH) is typically caused by a mutation in bone morphogenic protein receptor type 2 (BMPR2), and mice expressing Bmpr2 mutations develop PAH with features similar to human disease. BMPR2 is known to interact with the cytoskeleton, and human array studies in PAH patients confirm alterations in cytoskeletal pathways. The goal of this study was to evaluate cytoskeletal defects in BMPR2-associated PAH. Expression arrays on our Bmpr2 mutant mouse lungs revealed cytoskeletal defects as a prominent molecular consequence of universal expression of a Bmpr2 mutation (Rosa26-Bmpr2(R899X)). Pulmonary microvascular endothelial cells cultured from these mice have histological and functional cytoskeletal defects. Stable transfection of different BMPR2 mutations into pulmonary microvascular endothelial cells revealed that cytoskeletal defects are common to multiple BMPR2 mutations and are associated with activation of the Rho GTPase, Rac1. Rac1 defects are corrected in cell culture and in vivo through administration of exogenous recombinant human angiotensin-converting enzyme 2 (rhACE2). rhACE2 reverses 77% of gene expression changes in Rosa26-Bmpr2(R899X) transgenic mice, in particular, correcting defects in cytoskeletal function. Administration of rhACE2 to Rosa26-Bmpr2(R899X) mice with established PAH normalizes pulmonary pressures. Together, these findings suggest that cytoskeletal function is central to the development of BMPR2-associated PAH and that intervention against cytoskeletal defects may reverse established disease.
Inflammatory, Hemostatic, and Other Novel Biomarkers for Diabetic Retinopathy (2009)

There were few associations of novel markers of inflammation, hemostasis, and homocysteine with diabetic retinopathy after controlling for established risk factors. These data suggest that there is limited clinical use of these biomarkers for prediction of diabetic retinopathy.
Challenges in simulating beam dynamics of dielectric laser acceleration (2019)

Dielectric Laser Acceleration (DLA) achieves the highest gradients among structure-based electron accelerators. The use of dielectrics increases the breakdown field limit, and thus the achievable gradient, by a factor of at least 10 in comparison to metals. Experimental demonstrations of DLA in 2013 led to the Accelerator on a Chip International Program (ACHIP), funded by the Gordon and Betty Moore Foundation. In ACHIP, our main goal is to build an accelerator on a silicon chip, which can accelerate electrons from below 100 keV to above 1 MeV with a gradient of at least 100 MeV/m. For stable acceleration on the chip, magnet-only focusing techniques are insufficient to compensate the strong acceleration defocusing. Thus, spatial harmonic and Alternating Phase Focusing (APF) laser-based focusing techniques have been developed. We have also developed the simplified symplectic tracking code DLAtrack6D, which makes use of the periodicity and applies only one kick per DLA cell, which is calculated by the Fourier coefficient of the synchronous spatial harmonic. Due to coupling, the Fourier coefficients of neighboring cells are not entirely independent and a field flatness optimization (similarly as in multi-cell cavities) needs to be performed. The simulation of the entire accelerator on a chip by a Particle In Cell (PIC) code is possible, but impractical for optimization purposes. Finally, we have also outlined the treatment of wake field effects in attosecond bunches in the grating within DLAtrack6D, where the wake function is computed by an external solver.
An automated method for analysis of flow characteristics of circulating particles from in vivo video microscopy (2005)

The behavior of white and red blood cells, platelets, and circulating injected particles is one of the most studied areas of physiology. Most methods used to analyze the circulatory patterns of cells are time consuming. We describe a system named CellTrack, designed for fully automated tracking of circulating cells and micro-particles and retrieval of their behavioral characteristics. The task of automated blood cell tracking in vessels from in vivo video is particularly challenging because of the blood cells' nonrigid shapes, the instability inherent in in vivo videos, the abundance of moving objects and their frequent superposition. To tackle this, the CellTrack system operates on two levels: first, a global processing module extracts vessel borders and center lines based on color and temporal patterns. This enables the computation of the approximate direction of the blood flow in each vessel. Second, a local processing module extracts the locations and velocities of circulating cells. This is performed by artificial neural network classifiers that are designed to detect specific types of blood cells and micro-particles. The motion correspondence problem is then resolved by a novel algorithm that incorporates both the local and the global information. The system has been tested on a series of in vivo color video recordings of rat mesentery. Our results show that the synergy between the global and local information enables CellTrack to overcome many of the difficulties inherent in tracking methods that rely solely on local information. A comparison was made between manual measurements and the automatically extracted measurements of leukocytes and fluorescent microspheres circulatory velocities. This comparison revealed an accuracy of 97%. CellTrack also enabled a much larger volume of sampling in a fraction of time compared to the manual measurements. All these results suggest that our method can in fact constitute a reliable replacement for manual extraction of blood flow characteristics from in vivo videos.
The Yeast Yarrowia lipolytica as a Generic Tool for Molecular Evolution of Enzymes (2012)

It has been 20 years since strains of the yeast Yarrowia lipolytica were developed for the expression of recombinant proteins as alternative host to the commonly used yeasts, Pichia pastoris and Saccharomyces cerevisiae. Recently, a new strain, JMY1212, was engineered for protein evolution. With this new strain, a very high reproducibility in protein expression level was demonstrated, thus enabling its use for both rational and directed evolution strategies. Indeed, the coefficient of variation was shown to be of 10.7% for the whole process when all the steps are optimized, i.e. transformation of this strain with the gene of interest, cell growth, and protein production under oleic acid induction, and until activity screening assay. The object of this article is to summarize the fruit of these works and show the interest of Y. lipolytica strain JMY1212 for molecular evolution of enzymes, for both rational and directed evolution strategy. Lipase Lip2 from Y. lipolytica is taken here as an example to describe both strategies of molecular evolution. In these two methods, a first step of PCR creates either one targeted (rational design) or various random mutations (directed evolution), and is followed by the incorporation of the expression cassette in the genome of Y. lipolytica. An easy and direct comparison of variant properties is then allowed thanks to the extracellular and reproducible production of variants.
Isolation of a Unique Phosphopeptide from Skeletal-Muscle Phosphorylase Kinase, Labelled During Activation by Adenosine 3′:5′-Cyclic Monophosphate-Dependent Protein Kinase (1974)

Conference Article| February 01 1974 Isolation of a Unique Phosphopeptide from Skeletal-Muscle Phosphorylase Kinase, Labelled During Activation by Adenosine 3′:5′-Cyclic Monophosphate-Dependent Protein Kinase PHILIP COHEN PHILIP COHEN 1Department of Biochemistry, Medical Sciences Institute, University of Dundee, Dundee DD1 4HN, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1974) 2 (1): 82–83. https://doi.org/10.1042/bst0020082 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation PHILIP COHEN; Isolation of a Unique Phosphopeptide from Skeletal-Muscle Phosphorylase Kinase, Labelled During Activation by Adenosine 3′:5′-Cyclic Monophosphate-Dependent Protein Kinase. Biochem Soc Trans 1 February 1974; 2 (1): 82–83. doi: https://doi.org/10.1042/bst0020082 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1974 Biochemical Society1974 Article PDF first page preview Close Modal You do not currently have access to this content.
Detection of the plant parasite Cuscuta reflexa by a tomato cell surface receptor (2016)

Parasitic plants are a constraint on agriculture worldwide. Cuscuta reflexa is a stem holoparasite that infests most dicotyledonous plants. One exception is tomato, which is resistant to C. reflexa We discovered that tomato responds to a small peptide factor occurring in Cuscuta spp. with immune responses typically activated after perception of microbe-associated molecular patterns. We identified the cell surface receptor-like protein CUSCUTA RECEPTOR 1 (CuRe1) as essential for the perception of this parasite-associated molecular pattern. CuRe1 is sufficient to confer responsiveness to the Cuscuta factor and increased resistance to parasitic C. reflexa when heterologously expressed in otherwise susceptible host plants. Our findings reveal that plants recognize parasitic plants in a manner similar to perception of microbial pathogens.
A high speed embedded cache design with non-intrusive BIST (2002)

This paper describes a 155 MHz wide-word cache design and its test integration features. Design techniques for high speed CAM with single ended match line sensing and highly integrated RAM are described. A new cache BIST algorithm based on the SMARCH algorithm is presented. New techniques are described for the insertion of cache BIST access points into a high speed data path without compromising mission mode performance. Performance results of cache memory used for telecommunications microprocessor applications with 1 Kb of CAM referencing a 5 Kb RAM are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Inkjet printed circuits based on ambipolar and p-type carbon nanotube thin-film transistors (2017)

Ambipolar and p-type single-walled carbon nanotube (SWCNT) thin-film transistors (TFTs) are reliably integrated into various complementary-like circuits on the same substrate by inkjet printing. We describe the fabrication and characteristics of inverters, ring oscillators, and NAND gates based on complementary-like circuits fabricated with such TFTs as building blocks. We also show that complementary-like circuits have potential use as chemical sensors in ambient conditions since changes to the TFT characteristics of the p-channel TFTs in the circuit alter the overall operating characteristics of the circuit. The use of circuits rather than individual devices as sensors integrates sensing and signal processing functions, thereby simplifying overall system design.
Periprosthetic Fractures Associated with Primary Total Shoulder Arthroplasty and Primary Humeral Head Replacement (2012)

Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.
Visibility Editing For All‐Frequency Shadow Design (2010)

Abstract We present an approach for editing shadows in all‐frequency lighting environments. To support artistic control, we propose to decouple shadowing from lighting and focus on providing intuitive controls to edit the former. To accomplish this task, we precompute and store scene visibility information separately from lighting and BRDFs and allow artists to edit visibility directly, by providing operations to select shadows and edit their shape. To facilitate a wider range of editing operations, we generalize visibility from binary to three‐channel oating point quantities and introduce a novel shadow representation based on computation of visibility ratios between the original render and the edited one. We demonstrate our results for diffuse and glossy surfaces, still scenes and animations.
Acid‐Containing Tyrosine‐Derived Polycarbonates: Wettability and Surface Reactivity (2004)

Abstract Tyrosine‐derived polycarbonates having carboxylic acid pendant groups were characterized by water contact angle and X‐ray photoelectron spectroscopy (XPS). A pronounce decrease of receding angle as well as contact angle hysteresis as a function of acid composition strongly indicated that the acid groups are more accessible at the water/polymer interface after hydration. pH dependent contact angle confirmed an existence of carboxylic acid groups in the surface region. The receding angle transition appearing in the pH range of 4‐6 was a consequence of hydrophilicity change due to interconverting from carboxylic acid (‐COOH) to carboxylate ion (‐COO − ). The surface compositions of imidazole‐labeled polymers as analyzed by XPS were consistent with the bulk stoichiometry of the polymers. Reactivity of acid groups towards chemical reaction at the surface was also investigated. The acid groups at the surface of polymers were capable of adsorbing a significant amount of calcium ion from simulated body fluid and being activated by a reaction with N ‐hydroxysuccinimide.
Design and Magnetic Field Measurement of the Superconducting Magnets for the Next-Generation Rotating Gantry (2022)

This paper describes the design and reports the test results of the world's most compact rotating gantry for a heavy-ion therapy system mounted with superconducting bending and focusing magnets. A rotating gantry is cylindrical irradiation equipment with magnets for beam transport and beam scanning that delivers energetic carbon ions at up to 430 MeV/u precisely to a tumor from any direction without changing the posture of the patient. However, because of the high magnetic rigidity of therapeutic carbon ions, the rotating gantry was too big to be installed at general hospitals. Therefore, the superconducting rotating gantry had been developed in collaboration with Yamagata University. In the project, to achieve further downsizing of the rotating gantry, the length of the scanning irradiation system is reduced and the magnetic field of the superconducting magnet is increased to 3.5 T from the 2.88 T of the first superconducting gantry installed in the National Institutes for Quantum and Radiological Science and Technology (QST). As a result, the gantry is downsized to 2/3 of the first superconducting rotating gantry. This next-generation small superconducting rotating gantry has already been installed and is undergoing preclinical commissioning at Yamagata University.
Learning information release policies for preventing intersection attacks (2017)

Location Based Services in the world of mobile devices has been used widely in all sectors and in various applications. It allows one to track the location, track services and also perfom other location based operations. Although it's uses are very significant, the information related to location has opened up opportunities for adversary to misuse the mobile clients. This paper addresses one such problem with location information release and the problem addressed is mainly around Intersection Attacks. The two geo-spatial information over a period of time may be kept private but the time interval between the two specific time periods could lead to information leakage. This paper proposes two methodologies called “hierarchical signatures” and “Markov devision process” to mitigate intersection attacks. The paper also details the experimentation and results based on the tests done on two types of datasetc including reality mining datasets and telecommunication datasets.
HERPES SIMPLEX VIRUS MEDIATED NERVE GROWTH FACTOR EXPRESSION IN BLADDER AND AFFERENT NEURONS: POTENTIAL TREATMENT FOR DIABETIC BLADDER DYSFUNCTION (2001)

The NGF gene may be transferred and expressed in the bladder and bladder afferent pathways using HSV vectors. To our knowledge our study represents the first demonstration of the effectiveness of gene therapy for altering neurotrophic expression in visceral sensory neurons. This technique of gene transfer may be useful for treating certain types of neurogenic bladder dysfunction, such as diabetic cystopathy, in which decreased NGF transport may be a causative factor.
Polychromatic Diffractive Concentrators for Ultra-High Efficiency Photovoltaic Cells (2009)

I will describe an approach to achieve energy-conversion efficiencies &gt; 50via a thin nanostructured optic that not only concentrates sunlight, but also separates and assigns the solar-spectral components to photovoltaic cells with matching bandgaps. Article not available.