gebhart/patrepeval huggingface dataset:
VLSI Micro- and Nanophotonics (2011)

Addressing the growing demand for larger capacity in information technology, VLSI Micro- and Nanophotonics: Science, Technology, and Applications explores issues of science and technology of micro/nano-scale photonics and integration for broad-scale and chip-scale Very Large Scale Integration photonics. This book is a game-changer in the sense that it is quite possibly the first to focus on "VLSI Photonics". Very little effort has been made to develop integration technologies for micro/nanoscale photonic devices and applications, so this reference is an important and necessary early-stage perspective on this field. New demand for VLSI photonics brings into play various technological and scientific issues, as well as evolutionary and revolutionary challenges—all of which are discussed in this book. These include topics such as miniaturization, interconnection, and integration of photonic devices at micron, submicron, and nanometer scales. With its "disruptive creativity" and unparalleled coverage of the photonics revolution in information technology, this book should greatly impact the future of micro/nano-photonics and IT as a whole. It offers a comprehensive overview of the science and engineering of micro/nanophotonics and photonic integration. Many books on micro/nanophotonics focus on understanding the properties of individual devices and their related characteristics. However, this book offers a full perspective from the point of view of integration, covering all aspects of benefits and advantages of VLSI-scale photonic integration—the key technical concept in developing a platform to make individual devices and components useful and practical for various applications.
Spatiotemporally Non-Uniform Ca2+ Dynamics of Cardiac Purkinje Fibers in Mouse Myocardial Infarct (2017)

Surviving Purkinje fibers in myocardial infarct are regarded as an important substrate in arrhythmogenesis. However, poorly understood are functional properties of Purkinje fibers in the infarcted heart. We sought to visualize intracellular Ca<sup>2+</sup> ([Ca<sup>2+</sup>]<sub>i</sub>) dynamics of Purkinje fiber networks in the mouse myocardial infarct. Using 3- to 4-day-old or 7- to 9-day-old infarcted hearts after the left coronary-artery ligation corresponding, respectively, to acute or healing phase, we conducted rapid fluo4-fluorescence imaging on the endocardial surface of the left ventricular septum by macro-zoom fluorescence microscopy and rapid-scanning confocal microscopy. In contrast with the intact heart, where uniform Ca<sup>2+</sup> transients propagated rapidly, the infarcted heart exhibited slow, non-uniform impulse propagations. On confocal microscopy, Purkinje fibers in the peri-infarct zone exhibited non-uniform [Ca<sup>2+</sup>]<sub>i</sub> dynamics: beat-to-beat alternans of the Ca<sup>2+</sup> transient amplitude in and among the individual fibers, whereas the intact fibers exhibited uniform Ca<sup>2+</sup> transients. Such non-uniform [Ca<sup>2+</sup>]<sub>i</sub> dynamics were more conspicuous in the acute infarcted hearts than in the healing ones. In accordance with [Ca<sup>2+</sup>]<sub>i</sub> dynamics, fixed fluo4-loaded heart preparations exhibited definitive connexin-40 plaques in the peri-infarct Purkinje fibers, whereas the subjacent myocardium presented coagulative necrosis and granulation tissues, respectively. The surviving Purkinje fibers in the peri-infarct zone exhibited non-uniform [Ca<sup>2+</sup>]<sub>i</sub> dynamics, which may lead to arrhythmogenesis.
All-Optical Chromatic Dispersion Monitoring for Phase-Modulated Signals Utilizing Cross-Phase Modulation in a Highly Nonlinear Fiber (2008)

We propose and experimentally demonstrate an all-optical chromatic dispersion (CD) monitoring technique for phase-modulated signals utilizing the cross-phase-modulation effect between the input signal and the inserted continuous-wave probe. The probe's optical spectrum changes with the accumulated CD on the input signal, indicating that the optical power variations can be measured for monitoring. The experimental results show that this technique can monitor up to 120 ps/nm of CD for a 40-Gb/s return-to-zero differential phase-shift keying (RZ-DPSK) transmission system, with the maximum measured optical power increment of 16.5 dB. The applicability of this monitoring technique to higher bit-rate phase-modulated signals, such as 80-Gb/s RZ differential quadrature phase-shift keying and 80-Gb/s polarization-multiplexed RZ-DPSK, is also investigated via simulation.
Real-Time Fisheye Lens Distortion Correction Using Automatically Generated Streaming Accelerators (2009)

Fisheye lenses are often used in scientific or virtual reality applications to enlarge the field of view of a conventional camera. Fisheye lens distortion correction is an image processing application which transforms the distorted fisheye images back to the natural-looking perspective space. This application is characterized by non-linear streaming memory access patterns that make main memory bandwidth a key performance limiter. We have developed a fisheye lens distortion correction system on a custom board that includes a Xilinx Virtex-4 FPGA. We express the application in a high level streaming language, and we utilize Proteus, an architectural synthesis tool, to quickly explore the design space and generate the streaming accelerator best suited for our cost and performance constraints. This paper shows that appropriate ESL tools enable rapid prototyping and design of real-life, performance critical and cost sensitive systems with complex memory access patterns and hardware-software interaction mechanisms.
Binary carbonyls of platinum, Pt(CO)n (where n = 1-4). Comparative study of the chemical and physical properties of M(CO)n (where M = nickel, palladium, or platinum; n = 1-4) (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBinary carbonyls of platinum, Pt(CO)n (where n = 1-4). Comparative study of the chemical and physical properties of M(CO)n (where M = nickel, palladium, or platinum; n = 1-4)Ernst P. Kuendig, Douglas. McIntosh, Martin. Moskovits, and Geoffrey A. OzinCite this: J. Am. Chem. Soc. 1973, 95, 22, 7234–7241Publication Date (Print):October 1, 1973Publication History Published online1 May 2002Published inissue 1 October 1973https://pubs.acs.org/doi/10.1021/ja00803a009https://doi.org/10.1021/ja00803a009research-articleACS PublicationsRequest reuse permissionsArticle Views784Altmetric-Citations110LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ocena jakościowa ekologii samochodu elektrycznego na podstawie zużycia energii w rzeczywistym ruchu miejskim (2018)

Wydawnictwo SIGMA-NOT wydaje czasopisma fachowe informujące swoich czytelników o najnowszych osiągnięciach naukowych i nowoczesnych rozwiązaniach technicznych w Polsce i na świecie, popularyzuje problemy techniczne oraz poszerza wiedzę i kulturę techniczną.
Inhibition of MDA-MB-231 cell cycle progression and cell proliferation by C-2-substituted oestradiolmono- andbis-3-O-sulphamates (2005)

A natural metabolite of oestradiol (E2), 2-methoxyoestradiol (2-MeOE2), exerts both antitumour and antiangiogenic effects. 2-MeOE2 is currently in clinical trials for the treatment of a variety of cancers. We have previously shown that a number of sulphamoylated analogues of 2-MeOE2 possess enhanced potency and bioavailability with respect to 2-MeOE2. In our study, the effects of C-2-substituted E2 derivatives, with sulphamoylation at the C-3 and/or C-17 position, on ERalpha -ve MDA-MB-231 breast cancer cells were evaluated. Sulphamoylated derivatives were potent inhibitors of cell proliferation, and these effects were irreversible when compared to growth inhibitory effects induced by 2-MeOE2. Cell cycle analysis suggested that these derivatives caused cells to arrest at the G2-M phase of the cell cycle. Sulphamoylated analogues suppressed the clonogenic potential of MDA-MB-231 cells and also their growth on Matrigel culture substratum. Immunofluorescence studies showed fragmented nuclear bodies and an abnormal microtubule cytoskeleton in cells exposed to one of the potent compounds, 2-MeOE2-bis-sulphamate. In addition, these analogues induced phosphorylation of BCL-2, a protein considered to be the guardian of microtubule integrity. In each of the assays, the sulphamoylated derivatives were at least 10-fold more potent than the parent compound 2-MeOE2. In view of the enhanced potencies associated with sulphamoylated E2 derivatives in ERalpha -ve cells, these analogues should hold considerable therapeutic potential for the treatment of hormone-independent breast cancers.
Performance analysis of hybrid forward error correction schemes in a fast and slow Rician fading wideband land-mobile satellite channel with BPSK and path diversity (2002)

The performance of combined FEC/ARQ techniques for a direct-sequence CDMA system using coherent binary phase shift keying (BPSK) modulation is investigated. Throughput and delay are analyzed for the cases of slow and fast fading, considering the application of maximal ratio combining in light and heavy shadowing environments. By calculating the packet success probability, numerical results are presented for the throughput and delay. FEC with selective-repeat ARQ is implemented using BCH codes of varying lengths.
BdcA, a Protein Important for Escherichia coli Biofilm Dispersal, Is a Short-Chain Dehydrogenase/Reductase that Binds Specifically to NADPH (2014)

The Escherichia coli protein BdcA (previously referred to as YjgI) plays a key role in the dispersal of cells from bacterial biofilms, and its constitutive activation provides an attractive therapeutic target for dismantling these communities. In order to investigate the function of BdcA at a molecular level, we integrated structural and functional studies. Our 2.05 Å structure of BdcA shows that it is a member of the NAD(P)(H)-dependent short-chain dehydrogenase/reductase (SDR) superfamily. Structural comparisons with other members of the SDR family suggested that BdcA binds NADP(H). This was demonstrated experimentally using thermal denaturation studies, which showed that BcdA binds specifically to NADPH. Subsequent ITC experiments further confirmed this result and reported a Kd of 25.9 µM. Thus, BdcA represents the newest member of the limited number of oxidoreductases shown to be involved in quorum sensing and biofilm dispersal.
DAEMON Deliverable 2.2: Initial DAEMON Network Intelligence framework and toolsets (2022)

This is the second public deliverable of WP2 of the DAEMON project. It builds upon the material of the previous deliverable of WP2, i.e., D2.1, and on activities and results achieved during the first iteration of the project in WP3, WP4 and WP5. As a result, the document describes the following content. First, it provides significant updates to the functional and non-functional requirements of the eight NI-assisted functionalities tackled by DAEMON. These updates are mainly driven by the feedback provided by the implementation and evaluation activities of the project to date, which unveiled the need for adjustments to the original requirements or the addition of completely new ones. Second, it defines novel and equivalent functional and non-functional requirements for a NI plane, which the project proposes to complement existing network planes (e.g., user, control, management), and which lay the foundations to the modelling of the NI architectural framework targeted by the project. Third, based on the aforementioned requirements, it draft a preliminary yet complete design of the DAEMON’s NI plane, detailing its organization, its interaction with complementary blocks (e.g., traditional networking planes and machine learning operations), and its functioning in terms of NI instance coordination. Fourth, set forth a first set of project’s guidelines for the pragmatic design of NI. These span along two directions. First, a NI design tailored to the needs of B5G network management, orchestration and control. Second, a NI design that does not stretch the adoption of complex data-hungry black-box models for all possible any NI use cases; instead, it considers using more traditional, simpler, or interpretable models across the functionalities addresses in the project. Fifth, it summarizes the current status of a continuous review of the literature on NI and machine learning for mobile network management. This is a live effort that aims at keeping the project activities up to date with the current state of the art in scientific research, as well as to ultimately produce a complete survey and taxonomy of solutions for NI design and integration. As a result, the content of this document will be the basis on which the rest of the second iteration of the project activities will build upon. We expect that the updated design implementation of NI-assisted functionalities throughout the second iteration will be driven by the requirements set forth in this deliverable. Similarly, the alignment of the NI algorithm for orchestration via the NI plane will be carried out respect to the representation models presented in this deliverable, Finally, all evaluations will be aimed at verifying that the proposed solutions meet the project KPIs in terms of performance, but also the functional and non-functional requirements and NI design guidelines listed in this deliverable.
Scalarane sesterterpenes from Thorectidae sponges as inhibitors of TDP-43 nuclear factor (2014)

The analysis of two Thorectidae sponge samples, Hyrtios sp. and Petrosaspongia sp., collected at Fiji Islands, led to the isolation of five new scalarane derivatives along with fifteen known compounds. Their structures were elucidated on the basis of NMR and MS spectroscopic data. The small library of natural scalarane derivatives was investigated for their ability to modulate the activity of trans-activation response DNA-binding protein of 43 kDa (TDP-43), a key factor in several neurodegenerative conditions and the study resulted in the identification of potent inhibitors of TDP-43 protein.
Accéder en 3D aux données de terrain pluridisciplinaires - un outil pour l’étude des grottes ornées. (2019)

Dans le cadre des programmes ArTaPOC et PHYT, un outil de géoréférencement 3D a été développé. Il constitue un moyen de sauvegarder les informations, mais aussi de les croiser par l’intermédiaire d’une base de données associée à la 3D des cavités.Les données générées par les différentes disciplines à l’œuvre dans l’étude et la conservation des milieux endokarstiques sont difficilement exploitables dans leur globalité de par leur hétérogénéité, mais aussi de par les difficultés d’appréhension de leur organisation spatiale.Nous avons développé une solution logicielle sous la forme d’un plug-in pour le logiciel Meshlab lié à une base de données en ligne à laquelle nous apportons de nouvelles fonctionnalités qui concernent les éléments géoréférencés. Ces derniers sont des points placés sur des maillages issus de numérisation 3D. Ils contiennent les données des chercheurs qui peuvent être un nom, un commentaire, la discipline concernée, et des données spécifiques comme les valeurs de capteurs (températures et CO2) ou les résultats d’analyse physico-chimiques sous la forme de fichiers joints.Cette base de données est directement consultable dans le modèle 3D avec des outils de filtres et de recherche.La spatialisation des données permet une nouvelle approche dans leur analyse. En effet, de façon analogue aux SIG classiques, les positions 3D des enregistrements peuvent révéler des alignements, des regroupements, ou encore des manques selon des critères d’affichage choisis sur les données elles-mêmes. Il est par exemple possible de mettre en évidence d’un simple coup d’œil des zones d’une cavité ayant subi de fortes variations de températures.Afin de rendre l’utilisation encore plus simple, la visualisation du maillage et de la base de données est possible dans un casque de réalité virtuelle. Contrairement à un écran 2D représentant l’environnement 3D, et une souris 2D permettant de se déplacer, la navigation avec le casque est facilitée par l’immersion.Des expériences sont en cours en réalité mixte et augmentée afin de tester l’adjonction de la base de données sur l’environnement réel. Sur site, les chercheurs auront ainsi accès à leurs données directement dans des lunettes.
Data from IL6 Fuels Durable Memory for Th17 Cell–Mediated Responses to Tumors (2023)

&lt;div&gt;Abstract&lt;p&gt;The accessibility of adoptive T-cell transfer therapies (ACT) is hindered by the cost and time required for product development. Here we describe a streamlined ACT protocol using Th17 cells expanded only 4 days &lt;i&gt;ex vivo&lt;/i&gt;. While shortening expansion compromised cell yield, this method licensed Th17 cells to eradicate large tumors to a greater extent than cells expanded longer term. Day 4 Th17 cells engrafted, induced release of multiple cytokines including IL6, IL17, MCP-1, and GM-CSF in the tumor-bearing host, and persisted as memory cells. IL6 was a critical component for efficacy of these therapies via its promotion of long-term immunity and resistance to tumor relapse. Mechanistically, IL6 diminished engraftment of FoxP3&lt;sup&gt;+&lt;/sup&gt; donor T cells, corresponding with robust tumor infiltration by donor effector over regulatory cells for the Day 4 Th17 cell product relative to cell products expanded longer durations &lt;i&gt;ex vivo&lt;/i&gt;. Collectively, this work describes a method to rapidly generate therapeutic T-cell products for ACT and implicates IL6 in promoting durable immunity of Th17 cells against large, established solid tumors.&lt;/p&gt;Significance:&lt;p&gt;An abbreviated, 4-day &lt;i&gt;ex vivo&lt;/i&gt; expansion method licenses Th17 cells to confer long-lived immunity against solid malignancies via induction of systemic IL6 in the host.&lt;/p&gt;&lt;p&gt;&lt;i&gt;See related commentary by Fiering and Ho, p. 3795&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
Fundamental limitations on the capacity of wireless links that use polarimetric antenna arrays (2003)

It was recently speculated that six-component polarimetric antennas $comprising six co-located electric and magnetic dipoles that generate the six components of electric and magnetic current or that measure the six components of the electric and magnetic field - could give six-fold improvements in capacity over single-component antennas in Rayleigh flat fading. Using an exact wave propagation formulation involving the plane-wave spectral decompositions of the transmitted and scattered fields, we show that the behavior of wireless links based on arrays of polarimetric antennas is qualitatively different than that of links based on single polarimetric antennas. The MIMO channel can be viewed rigorously in the wavenumber domain. For dense planar arrays, the use of polarimetric antennas yields at most a fourfold improvement in capacity, which can be realized by particular combinations of four of the six dipoles. Six-component elements, the expansion of the planar arrays into volume arrays, or spacing elements at intervals less than a half-wavelength only give additional logarithmic improvements in capacity.
Physical, Chemical, and Microbiological Water Quality Variation between City and Building and within Multistory Building (2021)

Municipal drinking water entering buildings can experience degraded water quality due to in-building water treatment devices, plumbing design, materials, and occupancy patterns. To understand water quality patterns, we installed online sensors and collected grab samples throughout a multistory university building to quantify temporal and spatial fluctuations in temperature, pH, free chlorine, dissolved copper, trihalomethanes (THMs), cellular adenosine triphosphate (cATP), and organic matter surrogate (UV254). A whole-building water softener had a detrimental impact on water quality, increasing pH, decreasing disinfectant residual, and increasing THMs. Disinfectant residual was always greatest at the building inlet, with little to no measurable free chlorine at sinks and water fountains. Cellular adenosine triphosphate levels were lowest at the building inlet and measured greater at water fountains. Copper levels were <0.2 mg/L entering the building but ranged from 0.5 to 1.5 mg/L within the building. HVAC operations resulted in less variability for in-building water temperature than at the water treatment plant with temperatures averaging 5 °C warmer inside the building than at the building inlet. Trihalomethane concentrations were influenced by chlorine residual, pH, and water demand, with consistently higher in-building measurements than at the building inlet. Trihalomethane speciation remained constant throughout the study with chloroform being the greatest contributor to speciation, followed by dichlorobromoform, dibromochloromethane, and finally bromoform.
Spin fluctuations in the antiferromagnetic metalNb12O29 (2009)

We report a comprehensive study of the monoclinic ${\text{Nb}}_{12}{\text{O}}_{29}$ that includes material synthesis, chemical and structural characterization, and measurements of physical properties as a function of temperature, magnetic field, and high pressure. The high-pressure structural study has been carried out up to 71 kbar. Critical behavior analysis of $\ensuremath{\rho}(T)$ and ${C}_{\text{p}}(T)$ as ${T}_{\text{N}}$ is approached from ${T}_{\text{N}}^{+}$ is consistent with the picture of localized spins in this metallic antiferromagnet. These results also indicate that thermally driven critical fluctuations are confined to a temperature range in the vicinity of ${T}_{\text{N}}\ensuremath{\approx}12\text{ }\text{K}$. The thermoelectric power, however, is strongly enhanced at $T&lt;70\text{ }\text{K}$. The peculiar temperature dependence of the thermoelectric-power enhancement at low temperatures is consistent with predictions based on quantum critical fluctuations. We have also shown that the enhancement is suppressed under either a magnetic field or hydrostatic pressure.
Preparation of Annulated 2,4-Dioxygenated-5-Methylfurans (1991)

Abstract A concise route from dihydropyran to the furans 12 and 13 has been developed that takes advantage of the regioselective Baeyer-Villiger oxidation of bicyclic ketone 6.