gebhart/patrepeval huggingface dataset:
(Invited) Controlled Chemistry of Moisture Sensitive Reagents in Ionic Liquids (2010)

Many reactions involving phosphorus reagents require highly anhydrous and inert conditions for their successful implementation. In particular, the use of PCl3 and its derivatives for synthesis is often hampered by the inherent sensitivity of the materials themselves. Ionic liquids are emerging as green alternative solvents for a range of processes, and in particular have proven to be excellent media for highly sensitive phosphorus reagents without the need for anhydrous or inert conditions. Herein, we report the use of ionic liquids as both storage and reaction media which allows difficult and sensitive chemistry to be achieved in a more accessible manner.
Diverse and pervasive subcellular distributions for both coding and long noncoding RNAs (2016)

In a previous analysis of 2300 mRNAs via whole-mount fluorescent in situ hybridization in cellularizing Drosophila embryos, we found that 70% of the transcripts exhibited some form of subcellular localization. To see whether this prevalence is unique to early Drosophila embryos, we examined ∼8000 transcripts over the full course of embryogenesis and ∼800 transcripts in late third instar larval tissues. The numbers and varieties of new subcellular localization patterns are both striking and revealing. In the much larger cells of the third instar larva, virtually all transcripts observed showed subcellular localization in at least one tissue. We also examined the prevalence and variety of localization mechanisms for >100 long noncoding RNAs. All of these were also found to be expressed and subcellularly localized. Thus, subcellular RNA localization appears to be the norm rather than the exception for both coding and noncoding RNAs. These results, which have been annotated and made available on a recompiled database, provide a rich and unique resource for functional gene analyses, some examples of which are provided.
Bone voyage—Osteoblasts remotely control tumors (2017)

Tumor-driven systemic activation of osteoblasts in the bone promotes lung tumor growth
Relapse Detection in Patients with Psychotic Disorders Using Unsupervised Learning on Smartwatch Signals (2023)

Relapse detection is a crucial component of mental disorders treatment and management. In this paper, we present our solution for the ICASSP Signal Processing Grand Challenge e-Prevention track 2 Relapse Detection. We propose an unsupervised learning approach to detect relapse in patients with mental health disorders using anomaly detection with an autoencoder. To this end, we extract features from sleep, physical activity, and physiological data recordings. We train an autoencoder exclusively on non-relapse data. To detect relapses, we calculate the reconstruction error of the autoencoder and use it as an anomaly score. Our team, Emotion, ranked second in the e-prevention challenge with a ROC-AUC score of 0.6 and a PR-AUC score of 0.63 on the testing dataset.
Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells (2013)

Accurate detection and profiling of circulating tumor cells (CTCs) is a highly sought after technology to improve cancer management. Such "liquid biopsies" could offer a non-invasive, repeatable window into each patient's tumor, facilitating early cancer diagnosis and treatment monitoring. The rarity of CTCs, approximated at 1 CTC for every billion peripheral blood cells, however, poses significant challenges to sensitive and reliable detection. We have recently developed a new micro-nuclear magnetic resonance (μNMR) platform for biosensing. Through the synergistic integration of microfabrication, nanosensors, and novel chemistries, the μNMR platform offers high detection sensitivity and point-of-care operation, overcoming technical barriers in CTC research. We herein review the μNMR technology with emphasis on its application to CTC detection. Recent advances in the sensing technology will be summarized, followed by the description of the dynamic interplay between our preclinical and clinical CTC studies.
TRAK-Bestimmung: Aktuelles für die klinische Praxis (2005)

Beim Morbus Basedow stimulieren Autoantikörper (Ak) den TSH-Rezeptor (TSH-R) und verursachen so die Hyperthyreose. Der Nachweis der Ak ist daher ein wichtiges Hilfsmittel für Nachweis bzw. Ausschluss eines Morbus Basedow. Die Bestimmung der TSH-R-Ak hat verbreitet Anwendung gefunden und wird in der klinischen Diagnostik meist mittels Radio-Rezeptor-Assays durchgeführt, die TSH-binding-inhibition-Aktivität messen, wobei Schweine-Schilddrüsen-Rezeptoren (für die pTBII-Assay) Verwendung finden. Mit einer neueren Methode, die humane rekombinante TSH-Rezeptoren verwendet, konnte in mehreren Studien, eine signifikant höhere Sensitivität bei gleich bleibend hoher Spezifität zur Diagnose des Morbus Basedow demonstriert werden. Weitere Hauptindikationen sind die Vorhersage eines Rezidivs nach thyreostatischer Therapie und die Bestimmung von Krankheitsaktivität und Schweregrad der endokrinen Orbitopathie. Die vorliegende Arbeit gibt einen Überblick über die wichtigsten methodischen Aspekte mit Darstellung der Konsequenzen für die klinische Praxis.
Evaluation of a 4.5 kW Commercial Hall Thruster System for NASA Science Missions (2006)

The readiness of commercial Hall thruster technology is evaluated for near-term use on competitively-award, cost-capped science missions like the NASA Discovery program.Scientists on these programs continue to place higher demands on mission performance that must trade against the cost and performance of propulsion system options.Solar electric propulsion (SEP) systems can provide enabling or enhancing capabilities to several missions, but the widespread and routine use of SEP will only be realized through aggressive cost and schedule risk reduction efforts.Significant cost and schedule risk reductions can potentially be realized with systems based on commercial Hall thruster technology.The abundance of commercial suppliers in the United States and abroad provides a sustainable base from which Hall thruster systems can be cost-effectively obtained through procurements from existing product lines.A Hall thruster propulsion system standard architecture for NASA science missions is proposed.The BPT-4000 from Aerojet is identified as a candidate for near-term use.Differences in qualification requirements between commercial and science missions are identified and a plan is presented for a low-cost, low-risk delta qualification effort.Mission analysis for Discovery-class reference missions are discussed comparing the relative cost and performance benefits of a BPT-4000 based system to an NSTAR ion thruster based system.The BPT-4000 system seems best suited to destinations located relatively close to the sun, inside approximately 2 AU.On a reference near Earth asteroid sample return mission, the BPT-4000 offers mass performance competitive with or superior to NSTAR at much lower cost.Additionally, it is found that a low-cost, mid-power commercial Hall thruster system may be a viable alternative to aerobraking for some missions.Suggestions for the near-and far-term implementation of commercial Hall thrusters on NASA science missions are discussed.
Safety and Efficacy of Combined Yttrium 90 Resin Radioembolization with Aflibercept and FOLFIRI in a Patient with Metastatic Colorectal Cancer (2015)

Background. When associated with isolated four or fewer liver foci, metastatic colorectal cancer is amenable to surgical resection. Alternative therapeutic methods for isolated liver metastases include radioembolization with yttrium 90 (Y90) and transarterial chemoembolization (TACE). We present here a case of a patient with two sites of liver metastatic disease from colorectal cancer who underwent Y90 radioembolization combined with aflibercept and FOLFIRI. Case Report. A 56-year-old female with history of bilateral breast cancer and metastatic colon cancer with prior hemicolectomy and 4 previous chemotherapy regimens developed liver metastasis. She was started on aflibercept and FOLFIRI and concurrently underwent two treatments of radioembolization with Y90, initially targeting the largest right lobe tumor, and then a subsequent treatment targeting the smaller left lobe tumor with retreatment of the right lobe tumor. Her liver metastases exhibited partial response on imaging utilizing the modified RECIST criteria. Interestingly, the patient CEA levels decreased after the procedure. Discussion. This is the first reported case of a patient managed with radioembolization with Y90 combined with aflibercept, an anti-VEGF treatment, and FOLFIRI. An ongoing randomized clinical trial aims to define the role of combined targeted therapy and chemotherapy with radioembolization with Y90.
동물복지 관련 산란계 농가 실태조사 (2012)

본 조사는 산란계 케이지 사육시설에 대한 대체 사육시설 등 해결방안을 모색하기 위한 기초자료를 확보하기 위하여 평사, 방사사육 및 동물복지 사육시설을 사용하는 산란계 농가를 대상으로 사육시설에 대한 실태를 조사하였다. 사육형태는 방사사육, 평사사육 및 대체 사육시설 3가지로 구분되었으며, 축사형태는 무창축...
Low Power Consumption DQPSK Demodulator Using Silica-Based Planar Lightwave Circuit (2009)

We demonstrate a low power consumption differential quadrature phase-shift keying (DQPSK) demodulator using silica-based planar lightwave circuit (PLC) technology. A reduction of the power consumption is achieved by suppressing the temperature dependence of the circuit characteristic and eliminating a thermo-electric cooler (TEC) device. The maximum power consumption of the fabricated demodulator with an operating temperature range of -5degC to 70degC is 1.4 W, which is 60% lower than that of a conventional PLC demodulator with TEC. We report experimental results that demonstrate its good demodulation performance for a 43-Gb/s DQPSK system.
Advances in electronic and electrochemical ceramics : proceedings of the 107th annual meeting of The American Ceramic Society, Baltimore, Maryland, USA (2005) (2006)

Electronic Ceramics for Extreme Environments. Extreme Environment Potential of Diamond Derived Devices (R.S. Takalkar, P. Hamari, J.L. Davidson, W.P. Kang, P. Taylor, Y.M. Wong). Dielectric Powder/Polymer Composites for High Energy Density Capacitors (L.J. Gilbert, T.P. Schuman, F. Dogan). Barium Strontium Titanate Glass Ceramics for High Energy Density Capacitors (E.P. Gorzkowski, M.-J. Pan, B. Bender, C.C.M. Wu). Improved Electronics Reliability Using Thin Film Smart Materials for Mitigating Harsh Vibrational Environment (W.D. Nothwang, M.W. Cole, J.D. Demaree, J.K. Hirvonen, S.G. Hirsch, C. Hubbard, E. Ngo). Aluminum Nitride Dielectrics for High Energy Density Capacitors (K.R. Bray, R.L.C. Wu, S. Fries-Carr, J. Weimer). High Temperature Piezoelectric La2Ti2O7 (A. Sayir, S.C. Farmer, F. Dynys). Thermophysical Properties of Perovskite Type Alkaline Earth Hafnates (T. Maekawa, K. Kurosaki, H. Muta, M. Uno, S. Yamanaka, T. Matsuda, S.-I. Kobayashi). Thermophysical Properties of Sintered SrY2O4 and the Related Compounds Applicable to Thermal Barrier Coating Materials (T. Tanaka, K. Kurosaki, T. Maekawa, H. Muta, M. Uno, S. Yamanaka). Electrical Properties of Microwave Plasma Chemical Vapor Deposited Diamond Thin Films (R. Ramamurti, R.N. Singh, P.B. Kosel). Dielectric Properties of Suspensions Containing BaTiO3 Particles (A. Manohar, F. Dogan). Enhancement of Crystal Growth in Melt Texturing Ca-Doped Y-Ba-Cu-O Superconductors (O. Jongprateep, F. Dogan). Micro-Raman Spectroscopy of a Vickers Indent on Soft PZT (J. Jones, M. Hoffman). R-Curve And Stress-Strain Behavior Of Hard And Soft PZT Ceramics (J.L. Jones, M. Hoffman, W.F. Shelley II). Fuel Cells and Related Systems. Fabrication of SOFC Electrodes by Impregnation Methods (Y. Huang, J.M. Vohs, R.J. Gorte). Investigation of Nd0.6Sr0.4Co1-yMyO3-d (M = Fe and Mn) as Cathode Materials for Intermediate Temperature Solid Oxide Fuel Cells (K.T. Lee, A. Manthiram). Anode Supported Solid Oxide Fuel Cells With Improved Cathode/Electrolyte Interface (D. Montinaro, S. Modena, S. Ceschini, M. Bertoldi, T. Zandonella, A. Tomasi, V.M. Sglavo). Long-Term Effects in Ag-CuO Brazes Under Dual Reducing/Oxidizing Gas Conditions (K.S. Weil, J.Y. Kim, J.S. Hardy). Self Healing Glass Seals for Solid Oxide Fuel Cells (S. Parihar, R.N. Singh). Novel Sol-Gel Synthesis and Characterization of High-Surface-Area Pt-Ru Catalysts as Anodes for Direct Methanol Fuel Cells (M.K. Datta, J.Y. Kim, P.N. Kumta). Grain Boundary Segregation And Conductivity In Yttria-Stabilized Zirconia (M. Backhaus-Ricoult, M. Badding, Y. Thibault). Other Electronic Ceramic Applications. Electrically Conductive Mechanisms for Al2O3-C-TiCN Ceramics (H. Unno, J. Sugawara, T. Mukai ). Dielectric Properties Of High-K LTCC Materials (J.-P. Ganne, M. Pate, O. Durand, C. Grattepai). Monolithic Integration of Nonlinear Ba1-xSrxTiO3 Thin Films with Affordable Silicon Substrates for Frequency Agile Microwave Device Applications (M.W. Cole, W.D. Nothwang, R.G. Geyer).
High‐resolution expression profiling of selected gene sets during plant immune activation (2020)

The plant immune system involves detection of pathogens via both cell-surface and intracellular receptors. Both receptor classes can induce transcriptional reprogramming that elevates disease resistance. To assess differential gene expression during plant immunity, we developed and deployed quantitative sequence capture (CAP-I). We designed and synthesized biotinylated single-strand RNA bait libraries targeted to a subset of defense genes, and generated sequence capture data from 99 RNA-seq libraries. We built a data processing pipeline to quantify the RNA-CAP-I-seq data, and visualize differential gene expression. Sequence capture in combination with quantitative RNA-seq enabled cost-effective assessment of the expression profile of a specified subset of genes. Quantitative sequence capture is not limited to RNA-seq or any specific organism and can potentially be incorporated into automated platforms for high-throughput sequencing.
Delivery of Phosphodiester Oligonucleotides:  Can DOTAP/DOPE Liposomes Do the Trick? (2006)

Delivering phosphodiester ONs (PO-ONs) remains an attractive but challenging goal in antisense therapy. Both in the literature and in our experiments, most cationic liposomes fail in generating an antisense effect with PO-ONs, while they succeed with chemically modified ONs such as phosphothioate ONs (PS-ONs). This work aims to explain the biological activity of PO- and PS-ONs delivered by DOTAP/DOPE liposomes based on a detailed understanding of their cell biological behavior by means of fluorescence correlation spectroscopy and confocal laser scanning microscopy. We conclude that DOTAP/DOPE liposomes are not suited to deliver PO-ONs due to the release of naked PO-ONs in the cytosol at the time of the endosomal escape of the liposomes and the subsequent rapid degradation of the naked PO-ONs. Carriers that would not release the PO-ONs upon endosomal escape but would continue to carry the PO-ONs until they arrive at the target mRNA could therefore be better suited to delivering PO-ONs. In the case of PS-ONs, the ONs are not degraded upon release at the time of the endosomal escape of the liposomes, creating a pool of intact, biologically active PS-ONs and thus making DOTAP/DOPE liposomes mainly suitable for delivering nuclease resistant ONs. However, the cells seemed to display an export pathway for removing intact PS-ONs from the cells, limiting the presence of naked PS-ONs in the nucleus to approximately 8 h following the delivery.
Analysis of Sensor Attacks Against Autonomous Vehicles (2023)

Fully Autonomous vehicles (AV) are estimated to reach consumers widely in the near future.The manufacturers will have to be completely sure that AVs can outperform human drivers, which first of all requires a solid model of the world surrounding the car.Emerging trends for perception models in the automobile industry seems to be towards combining the data from LiDAR and camera in Multi-Sensor Fusion (MSF).Making the perception model reliable in the event of unforeseen real world circumstances is tricky enough, but the real challenge comes from the security issue that arises when ill-intentioned people try to attack sensors.In this article, we take a deep dive into the possible attacks and countermeasures for LiDAR and camera.We discuss it in the context of MSF, and provide a simple framework for further analysis, which we conclude will be needed in order to conceptualize a truly safe AV.
Gastrin-releasing peptide is a transmitter mediating porcine gallbladder contraction (1991)

We studied the role of gastrin-releasing peptide (GRP) for porcine gallbladder motility. Immunohistochemistry visualized nerve fibers containing GRP-like immunoreactivity in muscularis. GRP concentration dependently stimulated contractions of muscularis strips (ED50, 2.9 nM). Neuromedin B was less potent (ED50, 0.1 microM), suggesting existence of GRP-preferring receptors. GRP-induced contractions were unaffected by muscarinic antagonism (1 microM atropine), axonal blockade (1 microM tetrodotoxin), cholecystokinin (CCK) receptor antagonism (10 microM MK-329), or substance P desensitization (1 microM), supporting the existence of myogenic GRP receptors. The bombesin (BN) analogue D-Phe6-BN-(6-13)propylamide (PA) stimulated contractions (ED50, 3.3 nM) with low efficacy (29% of that of GRP). D-Phe6-BN-(6-13)PA (1 microM) shifted GRP concentration-response curves one log to the right. D-Phe6-BN-(6-13)PA interacted specifically with GRP receptors; while abolishing responses to GRP (1 nM), responses to substance P (0.1 microM) and CCK-8 (1 nM) were unchanged. Electrical stimulation (10 Hz, 0.5 ms, 10 V) caused a rapid onset-slow offset, tetrodotoxin-sensitive excitation. Atropine reduced the amplitude to 58% and caused a delayed, slow onset-slow decline response. D-Phe6-BN-(6-13)PA reduced the amplitude to 59% and caused a very rapid onset-rapid decline response. Atropine plus D-Phe6-BN-(6-13)PA abolished responses to nerve stimulation. Nerve stimulation caused significant release of GRP-like immunoreactivity. Thus two neural inputs were defined: a cholinergic rapid onset-rapid offset excitation and a delayed, slow onset-slow offset excitation caused by release and subsequent binding of GRP to GRP-preferring receptors.
Detection of Waterborne and Airborne Formaldehyde: From Amperometric Chemosensing to a Visual Biosensor Based on (2014)

A laboratory prototype of a microcomputer-based analyzer was developed for quantitative determination of formaldehyde in liquid samples, based on catalytic chemosensing elements. It was shown that selectivity for the target analyte could be increased by modulating the working electrode potential. Analytical parameters of three variants of the amperometric analyzer that differed in the chemical structure/configuration of the working electrode were studied. The constructed analyzer was tested on wastewater solutions that contained formaldehyde. A simple low-cost biosensor was developed for semi-quantitative detection of airborne formaldehyde in concentrations exceeding the threshold level. This biosensor is based on a change in the color of a solution that contains a mixture of alcohol oxidase from the yeast Hansenula polymorpha, horseradish
Noninvasive assessments of liver fibrosis with transient elastography and Hui index predict survival in patients with chronic hepatitis B (2014)

Baseline and change in noninvasive parameters of liver fibrosis, LSM and Hui index, are accurate to predict hepatic event-free survival in CHB patients.
Towards high density STT-MRAM at sub-20nm nodes (2018)

STT-MRAM are attracting an increasing interest from microelectronics industry. They are about to enter in volume production with the first goal of replacing embedded Flash memory. To go towards high density STT-MRAM at sub-20nm nodes, two major issues have to be solved. One is the nanopatterning of the magnetic tunnel junctions at 1x feature size (F) and narrow pitch (pitch<2F). The other is to increase the thermal stability of the storage magnetization at sub-20nm nodes. This paper addresses these two issues and propose innovative approaches to solve these two difficulties.
Hiding patterns with daylight fluorescent inks (2011)

We propose a method for hiding patterns within printed images by making use of classical and of two daylight fluorescent magenta and yellow inks. Under the D65 illuminant we establish in the CIELAB space the gamut of a classical cmyk printer and the gamut of the same printer using a combination of classical inks with daylight fluorescent inks. These gamuts show that a significant part of the classical ink gamut can be reproduced by combining classical inks with daylight fluorescent inks. By printing parts of images with a combination of classical and daylight fluorescent inks instead of using classical inks only, we can hide security patterns within printed images. Under normal daylight, we do not see any difference between the parts printed with classical inks only and the parts printed with daylight fluorescent inks and classical inks. By changing the illumination, e.g. by viewing the printed image under a tungsten lamp or under a UV lamp, the daylight fluorescent inks change their colors and reveal the security pattern formed by combinations of classical inks and of daylight fluorescent inks.
WE‐E‐141‐11: Optical Cone Beam 3D Tomography of Radiation Beams Using Cerenkov‐Excited Fluorescence (2013)

Purpose: Here, we explore a novel medical physics application of the Cerenkov effect for the dosimetric profiling of megavoltage beams used in radiation therapy. The technology to achieve these images has recently progressed from capturing single 2D projections with an intensified charge‐coupled device, to full 3D optical tomography using parallel beam back projection and a telecentric lens. In the current study, the method is extended to 3D imaging with a standard CMOS commercial camera and lens, using cone beam tomography algorithms for the reconstruction. Methods: Projection images of the induced Cerenkov light from a 20×20 cm 2 6 MV beam operating at a dose rate of 600 MU/min incident on a water tank with a 1.0 g/L concentration of Quinine Sulfate were captured from 0–360° with a 3° angular resolution and 5.0 second exposure time, resulting in a total scan time of 10 minutes. The resulting projection images were used in a Feldkamp‐Davis‐Kress (FDK) cone beam tomography algorithm to reconstruct the imparted 3D dose distribution. An accuracy analysis was performed by comparing the reconstructed lateral profile at a depth of 10 cm and a percent depth dose curve to a reference dose distribution from the treatment planning system (TPS). Results: A 3D dose distribution was successfully reconstructed from the captured projections yielding results which were within +/− 8% of the TPS dose distribution. Conclusion: Optical cone beam 3D tomography of radiation beams using Cerenkov‐excited fluorescence has been demonstrated for the first time. The proposed technique has several advantages over alternative methods (e.g., ionization chambers, scintillation, and gel dosimetry) including speed, flexibility, and necessitates only water, which serves as a cheap, abundant, and easily standardized tissue equivalent medium. Upon future refinement and improved accuracy the proposed modality may prove to be an important dosimetric tool with both clinical and research applications.