gebhart/patrepeval huggingface dataset:
Transition-state pliability in nitrogen-to-nitrogen proton transfer (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTransition-state pliability in nitrogen-to-nitrogen proton transferFredric M. Menger, Judy Grossman, and Dennis C. LiottaCite this: J. Org. Chem. 1983, 48, 6, 905–907Publication Date (Print):March 1, 1983Publication History Published online1 May 2002Published inissue 1 March 1983https://pubs.acs.org/doi/10.1021/jo00154a039https://doi.org/10.1021/jo00154a039research-articleACS PublicationsRequest reuse permissionsArticle Views60Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A stretchable EMI measurement sheet with 8&#x00D7;8 coil array, 2V organic CMOS decoder, and &#x2212;70dBm EMI detection circuits in 0.18&#x00BC;m CMOS (2009)

This paper present that the electromagnetic interference (emi) is a serious issue degrading the dependability of electronic devices. The issue is complicated by the following technology trends: 1) RF signals and clock pulses of digital ICs are in the same frequency range. 2) The increase of LSI power consumption causes an increase of noise emission. 3) Electronic devices have 3D-structures and packaging is dense. These trends also make the root cause analysis of EMI difficult. For example, it is difficult to find the EMI generation points in electronic devices such as cell-phones and PDAs. To solve the problem, an EMI measurement sheet is proposed, which enables the measurement of the EMI distribution on the surface of the electronic devices by wrapping the devices with a sheet like "furoshikildquo.
Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes (2011)

For most intracellular structures with larger than molecular dimensions, little is known about the connection between underlying molecular activities and higher order organization such as size and shape. Here, we show that both the size and shape of the amphibian oocyte nucleolus ultimately arise because nucleoli behave as liquid-like droplets of RNA and protein, exhibiting characteristic viscous fluid dynamics even on timescales of < 1 min. We use these dynamics to determine an apparent nucleolar viscosity, and we show that this viscosity is ATP-dependent, suggesting a role for active processes in fluidizing internal contents. Nucleolar surface tension and fluidity cause their restructuring into spherical droplets upon imposed mechanical deformations. Nucleoli exhibit a broad distribution of sizes with a characteristic power law, which we show is a consequence of spontaneous coalescence events. These results have implications for the function of nucleoli in ribosome subunit processing and provide a physical link between activity within a macromolecular assembly and its physical properties on larger length scales.
MoS2 Field-Effect Transistor for Next-Generation Label-Free Biosensors (2014)

Biosensors based on field-effect transistors (FETs) have attracted much attention, as they offer rapid, inexpensive, and label-free detection. While the low sensitivity of FET biosensors based on bulk 3D structures has been overcome by using 1D structures (nanotubes/nanowires), the latter face severe fabrication challenges, impairing their practical applications. In this paper, we introduce and demonstrate FET biosensors based on molybdenum disulfide (MoS2), which provides extremely high sensitivity and at the same time offers easy patternability and device fabrication, due to its 2D atomically layered structure. A MoS2-based pH sensor achieving sensitivity as high as 713 for a pH change by 1 unit along with efficient operation over a wide pH range (3-9) is demonstrated. Ultrasensitive and specific protein sensing is also achieved with a sensitivity of 196 even at 100 femtomolar concentration. While graphene is also a 2D material, we show here that it cannot compete with a MoS2-based FET biosensor, which surpasses the sensitivity of that based on graphene by more than 74-fold. Moreover, we establish through theoretical analysis that MoS2 is greatly advantageous for biosensor device scaling without compromising its sensitivity, which is beneficial for single molecular detection. Furthermore, MoS2, with its highly flexible and transparent nature, can offer new opportunities in advanced diagnostics and medical prostheses. This unique fusion of desirable properties makes MoS2 a highly potential candidate for next-generation low-cost biosensors.
<title>Time-varying M<formula><sup><roman>2</roman></sup></formula> in Q-switched lasers</title> (1992)

Numerical simulations of the pulse build-up in a Q-switched laser reveal a considerable change in the beam spatial profile during the pulse evolution, on a nanosecond time scale. Such changes were measured experimentally, and the measured temporal evolution of the beam profile is shown to be in good agreement with the theoretical results. The time evolution of the spatial profile translates into an evolution of the beam quality parameter M<SUP>2</SUP>; for typical experimental conditions, in a Nd:YAG laser utilizing a variable reflectivity mirror resonator<SUP>1</SUP>, M<SUP>2</SUP> is very close to a value of 1 at the beginning of the pulse, and increases smoothly throughout the pulse to reach a value of approximately 2 in correspondence of the pulse trailing edge.
Biomimetic and flexible piezoelectric mobile acoustic sensors with multiresonant ultrathin structures for machine learning biometrics (2021)

Flexible resonant acoustic sensors have attracted substantial attention as an essential component for intuitive human-machine interaction (HMI) in the future voice user interface (VUI). Several researches have been reported by mimicking the basilar membrane but still have dimensional drawback due to limitation of controlling a multifrequency band and broadening resonant spectrum for full-cover phonetic frequencies. Here, highly sensitive piezoelectric mobile acoustic sensor (PMAS) is demonstrated by exploiting an ultrathin membrane for biomimetic frequency band control. Simulation results prove that resonant bandwidth of a piezoelectric film can be broadened by adopting a lead-zirconate-titanate (PZT) membrane on the ultrathin polymer to cover the entire voice spectrum. Machine learning-based biometric authentication is demonstrated by the integrated acoustic sensor module with an algorithm processor and customized Android app. Last, exceptional error rate reduction in speaker identification is achieved by a PMAS module with a small amount of training data, compared to a conventional microelectromechanical system microphone.
Registered report: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs (2016)

The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The papers, which were published between 2010 and 2012, were selected on the basis of citations and Altmetric scores (Errington et al., 2014). This Registered Report describes the proposed replication plan of key experiments from "Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous 'mRNAs' by Tay and colleagues, published in Cell in 2011 (Tay et al., 2011). The experiments to be replicated are those reported in Figures 3C, 3D, 3G, 3H, 5A and 5B, and in Supplemental Figures 3A and B. Tay and colleagues proposed a new regulatory mechanism based on competing endogenous RNAs (ceRNAs), which regulate target genes by competitive binding of shared microRNAs. They test their model by identifying and confirming ceRNAs that target PTEN. In Figure 3A and B, they report that perturbing expression of putative PTEN ceRNAs affects expression of PTEN. This effect is dependent on functional microRNA machinery (Figure 3G and H), and affects the pathway downstream of PTEN itself (Figures 5A and B). The Reproducibility Project: Cancer Biology is a collaboration between the Center for Open Science and Science Exchange, and the results of the replications will be published by eLife.
Effects of Experimental Variables in Oxidations of Alkenes (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffects of Experimental Variables in Oxidations of AlkenesDale E. Van Sickle, Frank R. Mayo, Edwin S. Gould, and Richard M. ArluckCite this: J. Am. Chem. Soc. 1967, 89, 4, 977–984Publication Date (Print):February 1, 1967Publication History Published online1 May 2002Published inissue 1 February 1967https://pubs.acs.org/doi/10.1021/ja00980a040https://doi.org/10.1021/ja00980a040research-articleACS PublicationsRequest reuse permissionsArticle Views128Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Adaptive TTL-Based Caching for Content Delivery (2017)

Content Delivery Networks (CDNs) cache and serve a majority of the user-requested content on the Internet, including web pages, videos, and software downloads. We propose two TTL-based caching algorithms that automatically adapt to the heterogeneity, burstiness, and non-stationary nature of real-world content requests. The first algorithm called d-TTL dynamically adapts a TTL parameter using a stochastic approximation approach and achieves a given feasible target hit rate. The second algorithm called f-TTL uses two caches, each with its own TTL. The lower-level cache adaptively filters out non-stationary content, while the higher-level cache stores frequently-accessed stationary content. We implement d-TTL and f-TTL and evaluate both algorithms using an extensive nine-day trace consisting of more than 500 million requests from a production CDN server. We show that both d-TTL and f-TTL converge to their hit rate targets with an error of about 1.3%. We also show that f-TTL requires a significantly smaller cache size than d-TTL to achieve the same hit rate, since it effectively filters out rarely-accessed content.
Stabilization of Proteins by Nanoencapsulation in Sugar–Glass for Tissue Engineering and Drug Delivery Applications (2011)

A novel sugar–glass-nanoparticle (SGnP) system is developed to stabilize biomolecules for incorporation and delivery from a drug delivery system. It yields excellent protection from process-related stresses with little or no degradation, very good encapsulation efficiency, and storage stability, as well as giving burst-free sustained release for essentially any protein and polymer system of interest. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Glutamate Carboxypeptidase II Inhibition as a Novel Therapeutic Target (2005)

ConclusionWe have shown that 2-PMPA, an inhibitor of GCP II, was neuroprotective in in vitro and in vivo models of stroke and effectively attenuated neuropathic pain in a chronic constrictive injury model. These biological effects are likely mediated by GCP II inhibition-induced decreases in extracellular glutamate and/or increases in extracellular NAAG. Therefore, GCP II inhibition may be useful in neurological disorders in which excessive glutamate transmission is pathogenic. In addition, GCP II inhibition may represent a novel glutamate regulating strategy devoid of the side effects that have hampered the development of postsynaptic glutamate receptor antagonists. A lead GCP II inhibitor is currently completing Phase I clinical testing.
INORA-a unified signaling and routing mechanism for QoS support in mobile ad hoc networks (2003)

Mobile ad hoc networks (MANET) are characterized by bandwidth constrained wireless links, multiple hops and highly dynamic topologies. Providing QoS support in MANETs is hence a challenging task. This paper presents the design, implementation and evaluation of INORA, which is a network layer QoS support mechanism that makes use of the INSIGNIA in-band signaling mechanism and TORA routing protocol for MANETs. TORA provides multiple routes between a given source and destination. We present an effective coupling between TORA and INSIGNIA to get routes that are "best-able" to provide QoS requirements for a flow. INORA also combines congestion control with routing.
Further corroboration of distinct functional features in SCN2A variants causing intellectual disability or epileptic phenotypes (2019)

Our findings support the hypothesis that complete loss-of-function variants lead to ID without seizures, small gain-of-function variants cause BFNIE and EE variants exhibit variable but profound Na<sub>v</sub>1.2 gating changes. Moreover, structural modeling was able to predict the severity of the variant impact, supporting a potential role of structural modeling as a prognostic tool. Our study on the functional consequences of SCN2A variants causing the distinct phenotypes of EE, BFNIE and ID contributes to the elucidation of mechanisms underlying the broad phenotypic variability reported for SCN2A variants.
Dorzolamide and ocular blood flow in previously untreated glaucoma patients: a controlled double‐masked study (2002)

The present study indicated no measurable vascular effects from topical dorzolamide treatment in previously untreated glaucoma eyes.
Transmission spectroscopy on sawtooth-doping superlattices (1989)

We have performed transmission experiments on sawtooth-doping superlattices of short periodicity (100--200 A\r{}). Oscillations have been observed in the transmission spectra as a function of frequency due to the size quantization effect. We present a microscopic model of the transmission which takes into account the coupling between quantum wells in the superlattices. A Kronig-Penney model for a V-shaped quantum well is presented and the dispersion is calculated. It is found that interwell tunneling is only important for high subbands. The electron impurity scattering is included within Born approximation. The random-phase-approximation density correlation function is used for the interband absorption. Excellent agreement between theory and experiment is obtained.
The UK National Quantum Technologies Hub in sensors and metrology (Keynote Paper) (2016)

The UK National Quantum Technology Hub in Sensors and Metrology is one of four flagship initiatives in the UK National of Quantum Technology Program. As part of a 20-year vision it translates laboratory demonstrations to deployable practical devices, with game-changing miniaturized components and prototypes that transform the state-ofthe-art for quantum sensors and metrology. It brings together experts from the Universities of Birmingham, Glasgow, Nottingham, Southampton, Strathclyde and Sussex, NPL and currently links to over 15 leading international academic institutions and over 70 companies to build the supply chains and routes to market needed to bring 10-1000x improvements in sensing applications. It seeks, and is open to, additional partners for new application development and creates a point of easy open access to the facilities and supply chains that it stimulates or nurtures.
Driving Force and Kinetic Studies of Iodide Ion Uptake by Triphenylpyrylium Gallate Microcapsules, (2002)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTDriving Force and Kinetic Studies of Iodide Ion Uptake by Triphenylpyrylium Gallate Microcapsules†,‡Elena Y. Komarova, Kangtai Ren, and Douglas C. NeckersView Author Information Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403 Cite this: Langmuir 2002, 18, 20, 7753–7755Publication Date (Web):August 24, 2002Publication History Received13 May 2002Revised27 June 2002Published online24 August 2002Published inissue 1 October 2002https://pubs.acs.org/doi/10.1021/la025944bhttps://doi.org/10.1021/la025944bbrief-reportACS PublicationsCopyright © 2002 American Chemical SocietyRequest reuse permissionsArticle Views94Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Adsorption,Anions,Diffusion,Microparticles,Sorption Get e-Alerts
ChemInform Abstract: The Discovery of a Novel and Potent Benzodiazepine Receptor Pharmacophore. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Highly Sensitive MoS2 Photodetectors Enabled with a Dry-Transferred Transparent Carbon Nanotube Electrode (2023)

Fabricating electronic and optoelectronic devices by transferring pre-deposited metal electrodes has attracted considerable attention, owing to the improved device performance. However, the pre-deposited metal electrode typically involves complex fabrication procedures. Here, we introduce our facile electrode fabrication process which is free of lithography, lift-off, and reactive ion etching by directly press-transferring a single-walled carbon nanotube (SWCNT) film. We fabricated Schottky diodes for photodetector applications using dry-transferred SWCNT films as the transparent electrode to increase light absorption in photoactive MoS<sub>2</sub> channels. The MoS<sub>2</sub> flake vertically stacked with an SWCNT electrode can exhibit excellent photodetection performance with a responsivity of ∼2.01 × 10<sup>3</sup> A/W and a detectivity of ∼3.2 × 10<sup>12</sup> Jones. Additionally, we carried out temperature-dependent current-voltage measurement and Fowler-Nordheim (FN) plot analysis to explore the dominant charge transport mechanism. The enhanced photodetection in the vertical configuration is found to be attributed to the FN tunneling and internal photoemission of charge carriers excited from indium tin oxide across the MoS<sub>2</sub> layer. Our study provides a novel concept of using a photoactive MoS<sub>2</sub> layer as a tunneling layer itself with a dry-transferred transparent SWCNT electrode for high-performance and energy-efficient optoelectronic devices.
Functional modeling of pedaling kinematics for the Stroke patients (2020)

Understanding deficits in motor control through the analysis of pedaling biomechanics plays a key role in the treatment of stroke patients. A thorough study of the impact of different exercise patterns and workloads on the change between pre- and post-treatment movement patterns in the patients is therefore of utmost importance to the clinicians. The objective of this study was to analyze the difference between pre- and post-treatment pedaling torques when the patients are subject to different exercise groups with varying workloads. The effects of affected vs unaffected side along with the covariates age and BMI have also been accounted for in this work. Two different three-way ANOVA-based approaches have been implemented here. In the first approach, a random projection-based ANOVA technique has been performed treating the pedaling torques as functional response, whereas the second approach utilizes distance measures to summarize the difference between pre- and post-treatment torques and perform nonparametric tests on it. Bayesian bootstrap has been used here to perform tests on the median distance. A group of stroke patients have been studied in the Cleveland Clinic categorizing them into different exercise groups and workload patterns. The data obtained have been analyzed with the aforementioned techniques, and the results have been reported here. These techniques turn out to be promising and will help clinicians recommend personalized treatment to stroke patients for optimal results.
Investigations on quality factor of high frequency laterally vibrating LN on SiO<inf>2</inf> microresonators (2014)

This paper presents an investigation on the quality factor (Q) of Laterally Vibrating Resonators (LVRs) based on thin films of Y-cut ion-sliced Lithium Niobate (LN) on silicon dioxide (SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) that were first demonstrated in [1]. Devices operating between 500 MHz and 1.5 GHz were designed and fabricated to explore the dependence of Q on: (i) electrode coverage and location, (ii) air damping, (iii) temperature, (iv) frequency, and (v) vibration mode. A considerable increase in Q was attained when using smaller electrode coverage or strategically placing the electrodes at low strain locations. These results clearly indicate the impact of interfacial loss on Q. A minimal dependence of Q on pressure was found, implying that air damping has a minor effect in setting Q for these devices. Q vs. temperature of a characteristic resonator was also measured, hinting that damping mechanisms of thermoelastic nature are dominant in these devices.