gebhart/patrepeval huggingface dataset:
Serum Microbial- and Host-Derived Markers of Periodontal Diseases: A Review (2007)

Periodontitis is bacterial infection of tooth-supporting tissues leading to inflammation and, subsequently, to loss of teeth. It is one of the most common infections worldwide. Recent studies have shown that periodontal infection may pose a threat to general health by increasing the risk of cardiovascular and lung diseases, and preterm labour. Thus, useful markers of systemic exposure to periodontitis are needed. Markers of periodontitis in serum include those derived directly from periodontopathic pathogens and those originating from the host defence and immune mechanisms. Periodontitis is associated with endotoxemia, which can be directly measured as elevated concentrations of lipopolysaccharide (LPS) in periodontitis patients compared with healthy subjects. Also indirect methods determining endotoxemia, such as elevated concentrations of serum LPS binding protein, soluble CD14, and antibodies to LPS of periodontal pathogens have been reported. Surrogate measures of the host response against periodontal infection, such as matrix metalloproteinases, cytokines, chemokines, inflammation markers, antiphospholipid antibodies, and antibodies to periodontal pathogens, have been used. Of these, however, only antibodies to periodontal pathogens may be seen as specific markers of systemic exposure to periodontopathic pathogens. In this paper we describe and discuss serum markers of periodontitis that have been used for research purposes and/or to support diagnostics. Based on literature review, we encourage research and development of serum screening methods for periodontitis that could be used by general physicians.
Two-Step Color-Polarization Demosaicking Network (2022)

Polarization information of light in a scene is valuable for various image processing and computer vision tasks. A division-of-focal-plane polarimeter is a promising approach to capture the polarization images of different orientations in one shot, while it requires color-polarization demosaicking. In this paper, we propose a two-step color-polarization demosaicking network~(TCPDNet), which consists of two sub-tasks of color demosaicking and polarization demosaicking. We also introduce a reconstruction loss in the YCbCr color space to improve the performance of TCPDNet. Experimental comparisons demonstrate that TCPDNet outperforms existing methods in terms of the image quality of polarization images and the accuracy of Stokes parameters.
Genz-644282, a Novel Non-Camptothecin Topoisomerase I Inhibitor for Cancer Treatment (2011)

On the basis of preclinical activity and safety, Genz-644282 was selected for development and is currently undergoing phase 1 clinical trial.
Temporal Effects of Shock Wave Lithotripsy (1991)

Previous studies have demonstrated that renal parenchymal injury following extracorporeal shock wave lithotripsy is dependent upon shock wave power as well as the total number of shock waves administered. In order to determine the deleterious effects of temporal versus cumulative doses of shock wave administration, adult female rabbits were divided into five groups receiving either: 1000 shock waves in one session; 2000 shock waves in one session; 2000 shock waves in two sessions, one week apart; unilateral nephrectomy without lithotripsy; or anesthesia only as control population. One month following lithotripsy, renal functional studies for gamma glutamyl transferase and N-acetyl-beta-glucosaminidase revealed persistent enzymuria in the animals treated with 2000 shocks in one session. Pathologic studies in these animals confirmed an increased area of periglomerular and intratubular fibrosis when compared to animals managed by either 1000 shocks or 2000 shocks in divided doses (p less than 0.01). These findings suggest the importance of avoiding single treatments with large doses of shock waves and favor the administration of multiple small-doses of shock waves to minimize renal damage during the treatment of patients with hard or large calculi.
Mueller matrix roots algorithm and computational considerations (2011)

Recently, an order-independent Mueller matrix decomposition was proposed in an effort to elucidate the nine depolarization degrees of freedom [Handbook of Optics, Vol. 1 of Mueller Matrices (2009)]. This paper addresses the critical computational issues involved in applying this Mueller matrix roots decomposition, along with a review of the principal matrix root and common methods for its calculation. The calculation of the pth matrix root is optimized around p = 10(5) for a 53 digit binary double precision calculation. A matrix roots algorithm is provided which incorporates these computational results. It is applied to a statistically significant number of randomly generated physical Mueller matrices in order to gain insight on the typical ranges of the depolarizing Matrix roots parameters. Computational techniques are proposed which allow singular Mueller matrices and Mueller matrices with a half-wave of retardance to be evaluated with the matrix roots decomposition.
Accelerating Open vSwitch with Integrated GPU (2017)

With the fast development of Software Defined Networking (SDN) and network virtualization, software-based network virtual switches have emerged as a critical component to provide network services to VMs. Among virtual switches, Open vSwitch (OvS) is an open source virtual switch implementation commonly used and well-studied. Using Data Plane Development Kit (DPDK) with OvS to bypass the OS kernel and process packets in userspace provides tremendous performance benefits on general purpose platforms. Integrated GPUs, residing on the same die with the CPU on general purpose platforms, offering many advanced features such as on-chip interconnect CPU-GPU communication, and sharing physical/virtual memory, become a promising additional compute resource to further accelerate the OvS process. In this paper, we design and implement an inline GPU assisted OvS architecture, via offloading the expensive tuple space search to GPU and balancing switching processing between CPU and GPU. We evaluated the performance on an Intel® Xeon® processor of the E3-1575M v5 product family (code-name Skylake) with an integrated GT4e GPU. The results show that our proposed architecture improved the OvS throughput by 3x, compared to the optimized CPU-only OvS-DPDK implementation.
Energy-Efficient Near-Sensor Convolution using Pulsed Unary Processing (2019)

Near-sensor convolution engines have many applications in Internet-of-Things. Pulsed unary processing has been recently proposed for high-performance and energy-efficient processing of data using simple digital logic. In this work, we propose a low-cost, high-performance, and energy-efficient near-sensor convolution engine based on pulsed unary processing.
Microbubble response to dual frequency excitation for broadband contrast imaging (2016)

Contrast imaging relies on pulsing schemes like pulse inversion (PI), power-modulated pulse inversion (PMPI), and power modulation (PM) to isolate certain harmonic components. These multi-pulse schemes normally employ single frequency pulses (SFP). In this work, we propose dual frequency pulses (DFP) coupled with pulsing schemes (PI, PMPI, and PM) for microbubble imaging. The proposed DFP contain an amount b1 of a fundamental frequency f and an amount b2 of its phase-shifted (φ) second harmonic 2f. Microbubbles were excited with a variety of DFP combinations (b1, b2, φ) and their nonlinear response was compared to that from conventional SFP. All pulsing schemes benefit in terms of overall signal from the use of DFP by ~4–6 dB. PI benefits the most when coupled with DFP as it extracts an additional amount of nonlinear fundamental signal (~25 dB) something not feasible with SFP. It was observed that microbubble nonlinear response changes when the relative amount of f and 2f in DFP change, allowing the design of specific pulses for different microbubbles. In conclusion, since the use of DFP with pulsing schemes extracts harmonics more efficiently than SFP it has the potential to improve contrast imaging in terms of bubble sensitivity and image resolution.
Multilevel regulation of growth rate in yeast revealed using systems biology (2007)

The effect of changing growth rates on the transcriptome, proteome and metabolome has been systematically studied. Measurements made under varying nutrient conditions, corresponding to biochemical pathways that correlate primarily with growth rate, reveal a central role for mitochondrial metabolism and the TOR (target of rapamycin) signaling pathway.
Solid solubility and magnetism upon Mn incorporation in bulk Cr2AlC and Cr2GaC MAX phases (2014)

Herein we report on the bulk synthesis of (Cr1-xMnx)2AlC and (Cr1-yMny)2GaC MAX phases. Scanning electron and transmission electron microscopy in combination with energy dispersive X-ray spectrosco ...
Transform-domain Wiener filtering for H.264/AVC video encoding and its implementation (2005)

For coding efficiency as well as noise reduction, efficient de-noising needs to be performed prior to video encoding. This paper proposes a transform-domain Wiener filtering scheme in an H.264/AVC video encoder. We show that the generalized Wiener filtering for each integer-transformed block is equivalent to multiplication of multiplication factor (MF) in a block with a proper filter coefficient matrix in a quantization process. Also, we implement efficiently the proposed scheme by employing several predetermined modified MF's for quantization. Experimental results show that the proposed de-noising scheme provides outstanding coding efficiency as well as noise reduction in an H.264/AVC video encoder.
CuII binding sites located at His-96 and His-111 of the human prion protein: thermodynamic and spectroscopic studies on model peptides (2008)

The prion protein (PrP) is a Cu(2+)-binding cell-surface glycoprotein. Using PrP peptide fragments, by means of potentiometric, spectroscopic and thermodynamic techniques, we have shown that Cu(2+) ions bind to the region comprising His-96, His-111 and the octarepeat domain within residues 60-91. Cu(2+) may bind in different modes, which strongly depend both on His position within the peptide sequence and on the adjacent residues. We have used a series of protected oligopeptides having His at the C- or the N-terminus, inducing different binding modes to amide nitrogens around the His residue, either towards the N- or C-terminus. His imidazole acts as an anchoring site for Cu(2+) and then binding to ionized amide nitrogens follows. When it is directed towards the C-terminus the formation of a less stable seven-membered chelate ring with a {N(im), N(-)} binding mode occurs. When coordination goes towards the N-terminus the thermodynamically more stable six-membered chelate ring is formed. NMR data suggest that both the coordination modes are possible for the model peptides; however, the thermodynamic measurements show that they only slightly differ in energy and the influence of the adjacent amino acid residues can address the coordination toward the C- or the N-terminus.
Effect of Cytolethal Distending Toxin of Campylobacter jejuni on Adhesion and Internalization in Cultured Cells and in Colonization of the Chicken Gut (2006)

Campylobacter jejuni produces cytolethal distending toxin (CDT) that causes host cells to arrest during their cell cycle and that is involved in the pathogenesis of inflammatory diarrhea in humans. To assess the role of CDT in adherence and invasion of different cultured host cells (HeLa and HD-11) and in colonization of the chicken intestine, the genes of C jejuni NCTC11168 encoding the toxin subunits (cdtA, cdtB, and cdtC) were inactivated by insertional mutagenesis. No significant difference was found in adhesion of the wild-type C. jejuni and the isogenic mutants to HeLa and HD-11 cells. All of the mutants exhibited a decrease (>10-fold) in the ability to invade HeLa cells, but no significant difference was noticed for HD-11 cells. The ability of mutants to colonize birds either directly or by horizontal transfer was unchanged. These data indicated that although the production of cytotoxin does not play a role in the adherence to either human or avian cells, it may play a role in the invasion, survival, or both of C. jejuni in human cells, which are more susceptible to C. jejuni internalization. The CDT also does not seem to play a role in the colonization of poultry.
Enhanced renal function in bradykinin B2receptor transgenic mice (2000)

The tissue kallikrein-kinin system has been recognized as a paracrine and/or autocrine hormonal system that regulates arterial pressure, renal hemodynamics, and electrolyte excretion. We have created a transgenic mouse model overexpressing human bradykinin B(2) receptor, and the mice developed lifetime hypotension. With this animal model, we further analyzed the potential role of B(2) receptors in regulation of renal function. Baseline urinary excretion, urinary potassium excretion, and pH were significantly increased in transgenic mice, whereas urinary sodium excretion and serum sodium concentration were unaltered. Transgenic mice exhibited increased renal blood flow, glomerular filtration rate, and urine flow. Enhanced renal function was accompanied by significant increases in urinary nitrate/nitrite, cGMP, and cAMP levels with unaltered urinary kinin levels in transgenic mice compared with control siblings. Renal cGMP and cAMP content was also significantly increased in transgenic mice. Because the renin-angiotensin system exerts vasoconstriction buffering vasodilation of the kallikrein-kinin system, expression of renin-angiotensin components was examined by Northern blot analysis. We found a significant increase in hepatic angiotensinogen expression with no changes in renal renin and pulmonary angiotensin-converting enzyme mRNA levels in B(2) receptor transgenic mice. These studies showed that overexpression of B(2) receptors in transgenic mice resulted in hypotension and enhanced renal function through activation of nitric oxide-cGMP and cAMP signal transduction pathways.
Spleen Hemostasis Using High-Intensity Ultrasound: Survival and Healing (2002)

HIFU provides an effective and safe method of achieving hemostasis after acute splenic injury.
Hard x-ray photoelectron spectroscopy of buried Heusler compounds (2009)

This work reports on high energy photoelectron spectroscopy from the valence band of buried Heusler thin films (Co2MnSi and Co2FeAl0.5Si0.5) excited by photons of about 6 keV energy. The measurements were performed on thin films covered by MgO and SiOx with different thicknesses from 1 to 20 nm of the insulating layer and additional AlOx or Ru protective layers. It is shown that the insulating layer does not affect the high energy spectra of the Heusler compound close to the Fermi energy. The high resolution measurements of the valence band close to the Fermi energy indicate a very large electron mean free path of the electrons through the insulating layer. The spectra of the buried thin films agree well with previous measurements from bulk samples. The valence band spectra of the two different Heusler compounds exhibit clear differences in the low lying s bands as well as close to the Fermi energy.
Instigation and monitoring of inertial cavitation from nanoscale particles using a diagnostic imaging platform and passive acoustic mapping (2014)

Inertial cavitation nucleated by microbubble contrast agents has been recently shown to enhance extravasation and improve the distribution of anti-cancer agents during ultrasound (US)-enhanced delivery. However, microbubbles require frequent replenishment due to their rapid clearance and destruction upon US exposure and are unable to extravasate into tumor tissue due to their large size. A new generation of gas-stabilizing polymeric cup-shaped nanoparticles, or “nanocups” (NCs), have been formulated to a size that enables exploitation of the enhanced permeability and retention effect for intratumoral accumulation. NCs provide sustained inertial cavitation, as characterized by broadband emissions, at peak rarefactional pressures readily achievable by diagnostic ultrasound systems. This enables the use of a single low-cost system for B-mode treatment guidance, instigation of cavitation, and real-time passive acoustic mapping (PAM) of the location and extent of cavitation activity during therapy. The significant lowering of the inertial cavitation threshold in the presence of NCs as characterized by PAM is first quantified in-vitro. In-vivo and ex-vivo results in xenograft-implanted tumor bearing mice further evidence the strong presence of inertial cavitation detectable in the tumor at diagnostic levels of US intensity, as confirmed by PAM images overlaid on B-mode in real-time.
IEEE 802.11 Standards and Applications (2003)

This chapter contains sections titled: The IEEE 802.11a Task Group The IEEE 802.11b Task Group The IEEE 802.11d Task Group The IEEE 802.11e Task Group The IEEE 802.11f Task Group The IEEE 802.11g Task Group The IEEE 802.11h Task Group The IEEE 802.11i Task Group Physical Transmission Sharing Network Capacity Multipath Fading and Delay Spread Next Generation Wireless LANs Throughput versus Data Rate Cable Replacement versus Mobility Wireless LAN Components Wireless LAN Deployment Considerations Roaming and Handoff Health Concerns Site Survey Wireless Analyzers Network Management Applications Wi-Fi Deployment Summary References
Learned Vertex Descent: A New Direction for 3D Human Model Fitting (2022)

We propose a novel optimization-based paradigm for 3D human model fitting on images and scans. In contrast to existing approaches that directly regress the parameters of a low-dimensional statistical body model (e.g. SMPL) from input images, we train an ensemble of per-vertex neural fields network. The network predicts, in a distributed manner, the vertex descent direction towards the ground truth, based on neural features extracted at the current vertex projection. At inference, we employ this network, dubbed LVD, within a gradient-descent optimization pipeline until its convergence, which typically occurs in a fraction of a second even when initializing all vertices into a single point. An exhaustive evaluation demonstrates that our approach is able to capture the underlying body of clothed people with very different body shapes, achieving a significant improvement compared to state-of-the-art. LVD is also applicable to 3D model fitting of humans and hands, for which we show a significant improvement to the SOTA with a much simpler and faster method.
A new generation of polymer nanoparticles for drug delivery. (2004)

One of the main interests of using polymer nanoparticles as drug carrier systems is to control the delivery of the drugs including their biodistribution. During the last decade, it was clearly demonstrated that surface properties of nanoparticles were the key factor which determined the in vivo fate of such a carrier. Thus, the purpose of this work was to develop a new method which allows the easy fabrication of nanoparticles with versatile surface properties using polysaccharides. This preparation was based on the use of a redox radical polymerization reaction applied for the first time to the emulsion polymerization of alkylcyanoacrylates in aqueous continuous media. The dispersion of nanoparticles was very stable. The nanoparticle surfaces were coated with polysaccharides and their characteristics can be modulated by the type and the molecular weight of the polysaccharides used during the synthesis. Interestingly the biological properties of the polysaccharide immobilized on the nanoparticle surface can be preserved opening very interesting perspectives for such nanoparticles. This method also offers a new strategy for the design of modular biomimetic nanoparticles as drug carrier systems with multiple functions. One of the applications considered in this work was to use these nanoparticles coupled with haemoglobin as an oxygen carrier.
ChemInform Abstract: Vinyl Azides in Heterocyclic Synthesis. Part 2. Selectivity in the Decomposition of Azidocinnamates with Olefinic ortho‐Substituents. (1986)

Abstract The Starting compounds (I) and (II) are obtained in 28‐63% yield from the corresponding benzaldehydes by condensation with ethyl azidoacetate as described previously.
Potential impacts of agricultural chemicals on waterfowl and other wildlife inhabiting prairie wetlands: An evaluation of research needs and approaches (1986)

Acute intraoperative superior vena cava (SVC) syndrome is an exceedingly rare complication in the cardiac surgical population. We describe the case of a 71-year-old female undergoing multi-vessel coronary artery bypass grafting who developed acute intraoperative SVC syndrome following internal thoracic artery harvest retractor placement. Her symptoms included severe plethora, facial engorgement and scleral edema, which was associated with hypotension and severe elevation of central venous pressure. Transesophageal echocardiography was crucial in the diagnosis, management, and optimal retractor placement ensuring adequate SVC flow. Potential causes of intraoperative SVC syndrome are reviewed as well as management options.
Search for tRNA‐like properties in tomato aspermy virus RNA (1986)

The 3'‐terminal sequence of tomato aspermy virus (TAV, a cucumovirus) RNA can be arranged in an 'L'shaped conformation similar to that of the 3'‐tRNA‐like regions of the tyrosine‐accepting bromo‐, cucumoand hordeivirus RNAs examined to date. We report here that TAV RNA is recognized by the tRNA nucleotidyltransferase and can be adenylated nearly as efficiently as brome mosaic virus (BMV, a bromovirus) RNA. However, using tyrosyl‐tRNA synthetase from rat liver or from yeast, TAV RNA cannot be tyrosylated under conditions that allow aminoacylation of BMV RNA. Structural features in the 3'‐region could be responsible for the recognitory discrimination between the BMV and TAV RNAs by these eukaryotic tyrosyl‐tRNA synthetases.
Grain Growth Kinetics of AnBn Star Block Copolymers in Supercritical Carbon Dioxide (2005)

Using a series of AnBn miktoarm star block copolymers with different numbers of arms (n = 1, 2, 4, and 16), the effect of molecular architecture on the grain growth kinetics was investigated by ann...
Assembly of the Heparin Removal Device for patients with suspected adverse reaction to protamine sulphate (2000)

Protamine sulphate is routinely used after cardiopulmonary bypass (CPB) to restore the patient's baseline coagulatory state. However, adverse reactions are encountered, and alternative means to neutralize heparin are, therefore, necessary. The Heparin Removal Device (HRD) constitutes an extracorporeal circuit that allows ex vivo deheparinization by mean of a polycationic ligand that binds heparin molecules. This paper presents the setup of the HRD circuit. It is illustrated by the report of a 68-year-old man with a known severe crustacean allergy. The patient (78 kg, 170 cm) was admitted for elective coronary artery bypass graft surgery. It was decided that the HRD would be used as a precaution in order to avoid the risks of using protamine sulphate. The CPB time and aortic crossclamp time were 70 and 40 min, respectively. At the end of CPB, the device was inserted and processing started. Activated coagulation time values were monitored over a 130 min period and diminished from 480 to 300 s after 45 min, 220 s after 90 min, and settled at 150 s. Haemostasis was acceptable and processing stopped. The operation was terminated and the patient transferred to the intensive care unit. Clinical evolution was excellent, with minimal postoperative bleeding. The HRD presents an alternative to protamine sulphate when this drug is contraindicated for a certain patient population who might have a suspected, known or emergency adverse reaction.