gebhart/patrepeval huggingface dataset:
Beneficial Effect of Capsaicin Application to the Nasal Mucosa in Cluster Headache (1989)

Capsaicin application to human nasal mucosa was found to induce painful sensation, sneezing, and nasal secretion. All of these factors exhibit desensitization upon repeated applications. The acute effects induced by capsaicin (300 micrograms/100 microliters) application to the nasal mucosa were studied in healthy volunteers and cluster headache patients. These effects were not different in both nostrils of cluster headache patients as well as in the single nostril of healthy controls. Likewise, the time course of desensitization to the painful sensation and nasal secretion induced by capsaicin applied for five consecutive days in control subjects was almost superimposable to those observed in the nasal mucosa of cluster headache patients. The number of spontaneously occurring attacks was significantly reduced in the 60 days after the end of capsaicin treatment. Whether the beneficial effect induced by capsaicin application to the nasal mucosa could be ascribed to a specific action on sensory neurons remains unknown.
Insecticidal plant extracts from the Greek biodiversity: Biological activity and phytochemical characterization (2015)

Plant-derived extracts and compounds have been suggested as potential alternative insecticides. The large biodiversity, followed by incredible chemodiversity, even for species of the same family, creates a pool of bioactive ingredients, very little explored by now. Opposite to the synthetic ones, biopesticides are generally considered safer, posing fewer risks to the environment, with minimal impacts on animal and human health. Furthemore, natural compounds often act at multiple target sites, reducing the potential for resistance.
Editable dynamic textures (2003)

We present a simple and efficient algorithm for modifying the temporal behavior of "dynamic textures," i.e. sequences of images that exhibit some form of temporal regularity, such as flowing water, steam, smoke, flames, foliage of trees in wind. The main goal is to design algorithms for synthesizing and editing realistic sequences of images of dynamic scenes that exhibit some form of temporal stationarity. This is an image-based rendering task, and in particular we are interested in synthesizing the temporal behavior of the scene.
Amidothionophosphates: Novel Antioxidant Molecules (1996)

Abstract This work describes the synthesis and characterization of a new family of antioxidants. The molecules have the same active group, but different oil-to-water and octanol-to-water partition coefficients due to different substituents. Three new molecules were synthesized based on the chemical structure of the primary amide attached to a thiophosphate group forming an amidothionophosphate. The amidothionophosphate molecules were exposed to the oxidative stress of hydrogen peroxide and sodium hypochlorite, and the chemical changes following the exposure were monitored by 31P NMR. The reaction constants with reactive oxygen species such as hydroxyl radical and superoxide radical were also calculated and found to be 1.5∗109 M-1 and 8.1∗102 M-1S-1, respectively. In order to elucidate the ability of amidothionophosphates to act as antioxidants in protecting lipids and proteins, we examined damage prevention in Bovine serum albumin, egg phosphatidyl choline liposomes and lipid emulsions following oxidative smss. Amidothionophosphate showed unique protection properties in these models. In contrast to other antioxidant molecules (ascorbic acid, cystine, and a-tocopherol) the new group did not have any pro-oxidative effects as measured by oxygen consumption from buffer solutions containing amidothionophosphates and cupric sulfate as a redox-active metal. Amidothionophosphates reduced significantly and in a dose-dependent manner the oxidative burst in human neutrophils as measured by luminol-dependent chemiluminescence, and they also markedly depressed the killing of human fibroblasts by mixtures of glucose oxidase and streptolysin S. The toxicity of these molecules was tested by i.p. injection of up to 1000 mg/kg to white Sabra mice. No mortality was observed 30 days after administration of up to 500 mg/kg.
The impact of a magnesium zirconate thermal barrier coating on homogeneous charge compression ignition operational variability and the formation of combustion chamber deposits (2014)

The accumulation and burn-off of combustion chamber deposits create uncontrolled shifting of the homogeneous charge compression ignition operability range. This combustion chamber deposit–created operational variability places increased control burden on a multi-mode engine. However, the operational variability can be mitigated by manipulating combustion chamber deposit accumulation. A magnesium zirconate thermal barrier coating was applied to the piston of a homogeneous charge compression ignition engine in an effort to reduce combustion chamber deposit accumulation through elevated piston surface temperatures. While reduced combustion chamber deposit thicknesses were observed on the magnesium zirconate piston periphery, combustion chamber deposit accumulation in the bowl region increased relative to aluminum piston operation. Additionally, combustion chamber deposit thicknesses on the aluminum cylinder head were reduced during operation with the magnesium zirconate coated piston. Chamber-wide alterations to combustion chamber deposit accumulation taken together with the increased burn duration and hydrocarbon emissions measured during operation with the magnesium zirconate piston indicate significant interaction between the directly injected fuel spray and thermal barrier coating porosity. The porosity and surface roughness of the magnesium zirconate thermal barrier coating are speculated to create fuel pooling/absorption within the piston bowl, increasing combustion chamber deposit accumulation in the bowl and leaning the remaining fuel–air charge. The charge leaning lengthens the magnesium zirconate burn duration and reduces cylinder head combustion chamber deposit accumulation. Furthermore, hydrocarbon emissions were increased during magnesium zirconate operation due to late desorption and subsequent incomplete burning of fuel from piston bowl and the presence of incombustibly lean areas in the remaining cylinder charge.
Dioxin-Dependent and Dioxin-Independent Gene Batteries: Comparison of Liver and Kidney in AHR-Null Mice (2009)

The aryl hydrocarbon receptor (AHR) is a widely expressed ligand-dependent transcription factor that mediates cellular responses to dioxins and other planar aromatic hydrocarbons. Ahr-null mice are refractory to the toxic effects of dioxin exposure. Although some mechanistic aspects of AHR activity are well understood, the tissue specificity of AHR effects remains unclear, both during development and following administration of exogenous ligands. To address the latter issue, we defined and compared transcriptional responses to dioxin exposure in the liver and kidney of wild-type and Ahr-null adult C57BL/6J mice treated with either 2,3,7,8-tetrachlorodibenzo-p-dioxin or corn-oil vehicle. In both tissues, essentially all effects of dioxin on hepatic mRNA levels were mediated by the AHR. Although 297 genes were altered by dioxin exposure in the liver, only 17 were changed in the kidney, including a number of well-established AHR target genes. Ahr genotype had a large effect in both tissues, profoundly remodeling both the renal and hepatic transcriptomes. Surprisingly, a large number of genes were affected by Ahr genotype in both tissues, suggesting the presence of a basal AHR gene battery. Alterations of the renal transcriptome in Ahr-null animals were associated with perturbation of specific functional pathways and enrichment of specific DNA motifs. Our results demonstrate the importance of intertissue comparisons, highlight the basal role of the AHR in liver and kidney, and support a role in development or normal physiology.
Primary Nasal Epithelial Cells as a Surrogate Cell Culture Model for Type-II Alveolar Cells to Study ABCA-3 Deficiency (2022)

ATP Binding Cassette Subfamily A Member 3 (ABCA-3) is a lipid transporter protein highly expressed in type-II alveolar (AT-II) cells. Mutations in <i>ABCA3</i> can result in severe respiratory disease in infants and children. To study ABCA-3 deficiency <i>in vitro</i>, primary AT-II cells would be the cell culture of choice although sample accessibility is limited. Our aim was to investigate the suitability of primary nasal epithelial cells, as a surrogate culture model for AT-II cells, to study ABCA-3 deficiency. Expression of <i>ABCA3</i>, and surfactant protein genes, <i>SFTPB</i> and <i>SFTPC</i>, was detected in primary nasal epithelial cells but at a significantly lower level than in AT-II cells. ABCA-3, SP-B, and SP-C were detected by immunofluorescence microscopy in primary nasal epithelial cells. However, SP-B and SP-C were undetectable in primary nasal epithelial cells using western blotting. Structurally imperfect lamellar bodies were observed in primary nasal epithelial cells using transmission electron microscopy. Functional assessment of the ABCA-3 protein demonstrated that higher concentrations of doxorubicin reduced cell viability in ABCA-3 deficient nasal epithelial cells compared to controls in an assay-dependent manner. Our results indicate that there may be a role for primary nasal epithelial cell cultures to model ABCA-3 deficiency <i>in vitro</i>, although additional cell culture models that more effectively recapitulate the AT-II phenotype may be required.
Degradation of perchloroethylene and dichlorophenol by pulsed-electric discharge and bioremediation (1998)

Pulsed electric discharge (PED) and bioremediation were combined to create a novel two-stage system which dechlorinates the halogenated pollutants, 2,4-dichlorophenol and perchloroethylene, with repetitive (0.1-1 kHz), short pulse ( approximately 100 ns), low voltage (40-80 kV) discharges and then mineralizes the less chlorinated products with aerobic bacteria. A 6.1 mM aqueous dichlorophenol sample was cycled through the PED reactor (60 kV of applied pulsed voltage and 300 Hz) 6 times, resulting in the release of 55% of the initial dichlorophenol chloride ions (1 mM Cl- removed each cycle). The respective average specific efficiency is 0.4-0.6 keV/(Cl- molecule). Pseudomonas mendocina KR1, which grows in minimal medium supplemented with phenol but not with dichlorophenol, increased in cell density in all cultures supplemented with the PED-treated DCP samples and yielded a maximum of two-fold additional Cl- released compared to the PED-related alone. The number of PED-treatment cycles, voltage, and frequency were also varied, showing that both cell densities and overall dichlorophenol dechlorination were highly dependent upon the number of PED-treatment cycles, rather than the tested voltages and frequencies. Using this two-stage treatment system, PED released 31% of the initial chloride ions from dichlorophenol (after three cycles at 40-45 kV and 1.2 kHz) while P. mendocina KR1 in the second stage increased dechlorination to 90%. These results were corroborated by the 35% additional chloride release found with activated sludge cultures. Perchloroethylene (0.6 mM) was similarly treated in a first-stage PED reactor (80% chloride removal after four cycles) followed by biodegradation of the dechlorinated products with a recombinant toluene o-monooxygenase-expressing Pseudomonas fluorescens strain. Gas chromatographic analysis showed that the PED reactor created less-chlorinated byproducts (i.e., trichloroethylene) that were removed (74%) upon exposure to the recombinant bacterium. Copyright 1998 John Wiley & Sons, Inc.
Reliability of Post Plasma Oxidation Processed ALD Al 2 O 3 /Hf 1-x Zr x O 2 Thin Films on Ge Substrates (2017)

In this work, we have investigated the impact of Slot-Plane Antenna Plasma Oxidation (SPAO) on TiN/Hf1-xZrxO2/Al2O3/Ge gate stack with six different Zr content (0%, 25%, 33%, 50%, 75%, and 100%) in the dielectrics. The dielectrics were subjected to SPAO after the ALD deposition process prior to metal deposition. The equivalent oxide thickness (EOT), flat-band voltage (VFB), interface state density (Dit), C-V hysteresis, and leakage current (I-V) behavior were analyzed. It was observed that EOT decreases with Zr addition in HfO2 with up to 75% of Zr incorporation. While the devices with up to 75% of Zr demonstrated lower C-V hysteresis, flat-band voltage shift and mid-gap Dit tend to increase with decrease in EOT. With 100% Zr incorporation EOT increased significantly while reducing the mid-gap Dit. This behavior is mostly dependent on GeOx–like interfacial layer formation and defects at the interface.
Is Gödelian Model-based Deductive Reasoning Computational? (1998)

Q2 Do the mathematical facts revealed by Godel I imply that people have an ability that can never be matched by machines?Rather a lot of ink has been devoted to Q2 of late (some of it flowing from my own pen).Roger Penrose (Penrose, 1989(Penrose, , 1994)), for example, has famously argued that Q2 should be answered in the affirmative.Though I've been elsewhere concerned with Q2 (the bulk of my own writing on Q2 can be found in the chapter "Godel" (Bringsjord, 1992», this question is not my concern in the present paper.I'm not concerned here with whether Godel I itself implies that minds aren't machines; I'm concerned herein, if you will, with whether the human model-based reasoning that goes into proving Godel I is beyond computation.
L’antigène codé par les vaccins vectorisés dérivés de l’adénovirus humain de sérotype 5 est présenté de manière préférentielle aux lymphocytes T CD8+ par la sous-population CD8a+ de cellules dendritiques (2011)

Différentes sous-populations de cellules dendritiques (CD) induisent des réponses immunitaires qui sontqualitativement différentes. Chez la souris, deux sous-populations des CD sédentaires qui se trouvent dans letissu lymphoïde organisé, et qui sont distinguées par l’expression ou non du marqueur CD8a, ont été impliquéesrespectivement dans l’induction des réponses T helper 1 (Th1) ou Th2. De plus, les CD CD8a+ semblent jouer unrôle majeur dans l’initiation des réponses des lymphocytes T CD8+ aux antigènes viraux au cours de diversesinfections virales. Ces considérations sont moins bien explorées pour des vecteurs vaccinaux dérivés des virus.Malgré une transduction ex vivo des CD peu efficace, les vaccins vectorisés dérivés des adénovirus humains desérotype 5 (Ad5) induisent d’excellentes réponses immunitaires, caractérisées par une forte orientation Th1, chezl’homme et chez la souris. A présent on ne sait pas si l’Ad5 interagit avec des sous-populations des CD demanière différentielle, de façon à influer sur la qualité des réponses immunitaires induites. Ces informations sontrequises pour optimiser les interactions entre les vaccins dérivés de l’Ad5 et des sous-populations de CD, defaçon à amplifier les réponses immunitaires et même à induire des effecteurs immunitaires qui sont les plusappropriés pour le pathogène ciblé.Pour aborder cette question, nous avons exploré les interactions entre des vecteurs dérivés d’Ad5 et des souspopulationsCD8a+ et CD8a- des CD de la rate murine. A l’aide de vecteurs munis des transgènes qui codent laprotéine marqueur « green fluorescent protein » ou l’antigène modèle ovalbumine, différentes étapes(attachement du vecteur, expression du transgène, présentation d’antigène par les molécules du CMH classe I etactivation des lymphocytes T CD4+ et CD8+ spécifiques d’antigène) dans la séquence d’événements qui suitl’administration d’un vecteur vaccinal et conduit à l’induction des réponses immunitaires ont été étudiées dans lessous-populations CD8a+ or CD8a- de CD murines.Bien que dans les expériences menées ex vivo et in vivo les CD CD8a+ and CD8a- aient capté un vecteur dérivéde l’Ad5 avec la même efficacité, l’expression du transgène et la présentation d’un antigène codé par letransgène par les molécules du CMH classe I ont été plus efficaces dans les CD CD8a+. De plus, aprèstransduction in vivo et ex vivo avec un vaccin dérivé d’Ad5, les lymphocytes T CD8+ spécifiques d’antigène ontété activés plus efficacement par les CD CD8a+ que par les CD CD8a-.En conclusion, une meilleure expression d’antigène et une meilleure présentation par le CMH classe I dans lesCD CD8a+ pourraient contribuer à une activation préférentielle des lymphocytes T CD8+ spécifiques d’antigènepar les CD CD8a+ transduites par l’Ad5.
Copper-catalyzed aerobic carboxygenation and N-arylation of [1,2,3]triazolo[1,5-a]pyridines towards pyridinium triazolinone ylides (2015)

Copper-catalyzed aerobic oxyarylation of [1,2,3]triazolo[1,5-a]pyridines is developed. Notably molecular oxygen was utilized as one of the reagents and the transformation resulted in the formation of novel pyridinium triazolinone ylides. A basic mechanism for the one-pot process is proposed and further functionalization of the ylidic products were also presented.
Single-Chip Multiprocessors: The Next Wave of Computer Architecture Innovation (2004)

The past 25 years have been a very exciting time for computer architecture. A lot of this excitement was due to new opportunities made available by semiconductor technology: once basic uniprocessor functionality could be implemented on a chip, additional transistor resources could be used for innovative uniprocessor microarchitectures. The net result is that the microarchitecture of a high-performance uniprocessor today barely resembles that of one from 20 years ago. Today we stand at the doorstep of a similar period of excitement for multiprocessors. Semiconductor technology currently allows us to build a small chip multiprocessor. While the microarchitecture of the initial chip multiprocessors differs little from that of a traditional multiprocessor built with multiple chips, advances in semiconductor technology will allow us to rethink the microarchitecture of multiprocessors. Now is the time to start investigating innovative ways of architecting chip multiprocessors. This talk will try to provide some initial directions towards this overall research agenda.
Directional Interference Supression Based on Blind Source Separation with Beamforming (2014)

Strong interference severely affects weak targets detection capability of the passive sonar. This paper proposes a method to cancel the directional strong interference based on blind source separation(BSS) and beamforming. The main steps proposes of the method are as follows. Firstly, it uses the steered beamforming technology to estimate the interference signals. Secondly, it uses the plural blind source separation algorithm to get the separated signals and demixing matrix from the frequency domain sub-band mixed signals transformed from the time domain received mixed signals. It uses frequency spectrum correlation to compare the separated signals and the interference signals, and the interference signals will be rejected in this step. It will also cluster the separated signals and reconstruct them back to the array domain. Finally, it uses beamforming to estimate the targets bearings. Simulator and sea trial datasets are used to verify the proposed method, and the results show that the method can suppress the directional strong interference efficiently, which enhances the detection capability of the passive sonar for weak targets.
Technical Notes on a Radiolucent Distractor for Indirect Reduction and Intramedullary Nailing (1997)

For many years, the fracture table has served as the gold standard for the application of the distraction forces necessary to indirectly reduce fractures during internal fixation procedures. However, the fracture table is expensive, often is cumbersome, requires intraoperative adjustment by "nonscrubbed" personnel, can be difficult to use in the care of multiply traumatized patients, and often is unsuitable for the morbidly obese patient. This technical note describes the application of distraction with a sterile device that is used "in the surgical field" and applies distraction from a K-wire (or Steinman pin) tensioner to either another K-wire tensioner or a "perineal post." The multiply traumatized patient who is placed on a radiolucent table for thoracoabdominal procedures can undergo intramedullary nailing using this device without requiring transfer to a fracture table (or alternatively without requiring that surgical team members apply manual distraction during the nailing procedure). Such a device also can be used to apply distraction for tibial nailing, for indirect reduction and plating, and for hip and ankle arthroscopy.
Endemic Goiter in Sarawak, Borneo Island; Prevalence and Pathogenesis (1972)

A survey for endemic goiter was carried out on Iban natives (Sea Dayak) in four districts along the Rajang River in Sarawak, Borneo Island.Among 608 subjects (271 males and 337 females) examined, 134 subjects (22 males and 112 females) were found to be goitrous, the prevalence of goiter being 8.1 for male and 33.2% for female. None were clinically hypo-or hyperthyroid, no cretinism was detected.Twenty-four hr. thyroidal 131I-uptake was 54.3±13.1 %(mean±S. D.) in goitrous subjects while 47.1±10.2% in non-goitrous (no statistical significance). Urinary excretion of iodine was 45±27μg per day in goitrous group and 49±25μg in nongoitrous group (no significance). Iodine content of drinking water was extremely low in all four districts, the lowest one being obtained from region in which the prevalence of goiter is highest. Thyroid parameters such as PBI, T3 resin sponge uptake and cholesterol were all within normal limits. Anti-thyroid antibodies were not demonstrated in sera from either goitrous or nongoitrous subjects. KSCN discharge test was positive in two cases in a single family, among 33 cases studied.Experimental feeding of cassava on our expedition members for two weeks did not show any change in thyroid parameters including KSCN discharge test.It is thought that iodine deficiency is probably a major causative factor of endemic goiter in Sarawak, Borneo Island. Other factors such as organification defect or defective thyroxine binding proteins might have some role in individual cases.
Signal and Power Integrity (2008)

This chapter contains sections titled: Introduction Interconnect Resistance, Capacitance, and Inductance Inductance Effects on an Interconnect References
The Synthesis of 1,2,3-Triazoles from Nitroalkenes - Revisited (2005)

International audience
Direct Display of Integer ACES Content for Post-Production Environments (2011)

The Image Interchange Framework (IIF), created by AMPAS with the goal of providing a unified post-production workflow, has seen increased interest in recent years. Central to the IIF is the RGB wide-gamut color space defined by the Academy Color Encoding Specification (ACES). For output device viewing, the ACES data must first be rendered through the Reference Rendering Transform (RRT) and the Output Device Transform (ODT). Recently a quasi-logarithmic 12 bit integer ACES encoding scheme was proposed, and we present initial results on the direct display of integer ACES content on a Dolby PRM-4200 monitor. Frames were delivered directly to the monitor across a 12 bit dual link SDI interface, and the decoding, as well as the RRT and device ODT were computed via 1D and 3D LUTs resident on the monitor. Several different LUT designs were considered, and the limitations of each including failure modes will be discussed.