gebhart/patrepeval huggingface dataset:
Anchoring Property of a Novel Hydrophilic Lipopolymer, HDAS-SHP, Post-Inserted in Preformed Liposomes (2019)

Polyethylene glycol (PEG)-phospholipids in long-circulating liposomes cause non-specific immune reactions; mainly attributable to negatively-charged phosphoryl s at the interface of PEG and phospholipid. We investigated a novel lipopolymer, by which a superhydrophilic polymer (SHP) is conjugated to a non-phospholipid N<sup>1</sup>-(2-aminoethyl)-N<sup>4</sup>-hexadecyl-2-tetradecylsuccinamide (HDAS). The modification of preformed liposomes HDAS-SHP, HDAS-PEG<sub>2000</sub>, and DSPE-PEG<sub>2000</sub> were performed by post-insertion techniques. The efficiency of post-insertion and desorption rates, from the liposome surface, were determined. HDAS-SHP micelles showed highly positive zeta potential (+28.4 mV); zeta potentials of DSPE-PEG<sub>2000</sub> and HDAS-PEG<sub>2000</sub> micelles were -34.4 mV, and -3.7 mV, respectively. Critical micelle concentration predicted amphiphilicity of HDAS-SHP (CMC 2.58 µM) as close to that of DSPE-PEG<sub>2000</sub> (CMC 2.44 µM). Both HDAS-SHP and HDAS-PEG<sub>2000</sub> post-inserted with comparable efficiency (79%, and 73%, respectively), but noticeably lower than DSPE-PEG<sub>2000</sub> (90%). The desorption rate of HDAS-SHP was close to that of DSPE-PEG<sub>2000</sub> (0.53%/h, and 0.45%/h, respectively); the desorption rate for HDAS-PEG<sub>2000</sub> was slightly more at 0.67%/h. Compared to plain liposomes, both HDAS-SHP- and DSPE-PEG<sub>2000</sub>-liposomes showed significant leakage of encapsulated Na-fluorescein isothiocyanate (FITC) upon incubation with serum. At the same time, both modified liposomes were found to suppress serum levels of the complement proteins, Bb and C4d. We infer that HDAS-SHP is a viable alternative to commonly-used PEG-phospholipid derivatives for stealth purposes.
Tissue deposition and toxicological effects of commercially significant rare earth oxide nanomaterials: Material and physical properties (2016)

Rare earth oxide (REO) materials are found naturally in earth's crust and at the nanoscale these REO nanoparticles exhibit unique thermal, electrical, and physicochemical properties. REO nanoparticles are widely used in different industrial sectors for ceramics, glass polishing, metallurgy, lasers, and magnets. Recently, some of these REO nanoparticles have been identified for their potential application in medicine, including therapy, imaging, and diagnostics. Concurrent research into the REO nanomaterials' toxicities has also raised concern for their environmental impacts. The correlation of REO nanoparticles mediated toxicity with their physiochemical properties can help to design nanoparticles with minimal effect on the environment and living organisms. In vitro assay revealed toxicity toward Human squamous epithelial cell line (CCL30) and Human umbilical vascular endothelial cells (HUVEC) at a concentration of 100 µM and higher. In vivo results showed, with the exception of CeO<sub>2</sub> and Gd<sub>2</sub> O<sub>3</sub> , most of the naoparticles did not clear or had minimum clearance (10-20%) from the system. Elevated levels of alanine transferase were seen for animals given each different nanoparticle, however the increases were not significant for CeO<sub>2</sub> and Dy<sub>2</sub> O<sub>3</sub> . Nephrotoxicity was only seen in case of Dy<sub>2</sub> O<sub>3</sub> and Gd<sub>2</sub> O<sub>3</sub> . Lastly, histological examination revealed presence of swollen hepatocytes which further confirms toxicity of the commercial REO nanomaterials. The in vivo toxicity is mainly due to excessive tissue deposition (70-90%) due to the commercial REO nanoparticles' poor physical properties (shape, stability, and extent of agglomeration). Therefore, optimization of nanoparticles physical properties is very important. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 904-917, 2017.
Visual pattern discovery in timed event data (2011)

Publisher’s Note: This paper, originally published on 24 January 2011, was replaced with a corrected/revised version on 9 April 2015. If you downloaded the original PDF but are unable to access the revision, please contact SPIE Digital Library Customer Service for assistance. Business processes have tremendously changed the way large companies conduct their business: The integration of information systems into the workflows of their employees ensures a high service level and thus high customer satisfaction. One core aspect of business process engineering are events that steer the workflows and trigger internal processes. Strict requirements on interval-scaled temporal patterns, which are common in time series, are thereby released through the ordinal character of such events. It is this additional degree of freedom that opens unexplored possibilities for visualizing event data. In this paper, we present a flexible and novel system to find significant events, event clusters and event patterns. Each event is represented as a small rectangle, which is colored according to categorical, ordinal or intervalscaled metadata. Depending on the analysis task, different layout functions are used to highlight either the ordinal character of the data or temporal correlations. The system has built-in features for ordering customers or event groups according to the similarity of their event sequences, temporal gap alignment and stacking of co-occurring events. Two characteristically different case studies dealing with business process events and news articles demonstrate the capabilities of our system to explore event data.
Overexpression of oxytocin receptors in the hypothalamicPVNincreases baroreceptor reflex sensitivity and buffersBPvariability in conscious rats (2014)

OT receptors in PVN are involved in tonic neural control of BRS and cardiovascular short-term variability. The failure of this mechanism could critically contribute to the loss of autonomic control in cardiovascular disease.
A vibrational study of poly (L‐proline) I and II in the far infrared (1975)

Abstract The far infrared spectra of poly( L ‐proline) I (190–35 cm −1 ) and II (400–35 cm −1 ) were obtained in the solid state at both 300° and 110°K. A significant difference in the region below 100 cm −1 was observed. A very intense band located at 60 cm −1 in the infrared spectrum of form II has no counterpart in form I. This indicates the sensitivity of low‐frequency vibrations to the difference in conformation assumed by both forms in the solid state. Additional bands observed in this study are correlated with ir and Raman data previously reported and tentative assignments are made using the results of normal mode calculations (in the single‐chain approximation) which have been reported.
Semiautomatic Finite Element Mesh Generation of Biological Soft Tissue by Using 3-Dimension Internal Structure Microscope (2005)

In a dynamic analysis of biological sample using finite element method, generally biological mesh models are made of X ray CT or MN1 image data. These images resolution are about 1 mm, but some biological tissues' sizes are less than 1 mm. In this study, we proposed digitizing with 3-dimention internal structure microscope (3D-ISM). This device slices a fixed sample, and obtains a cross-sectional image that is μm order. In addition, we propose the method of generating the mesh model of high accuracy from the observation data of 3D-ISM as it is semiautomatic. Shape and quality were compared by voxel mesh and mapped mesh. As for shape mapped mesh can represent detail of each eye tissue. As for quality voxel mesh is constancy. In mapped mesh, we compared three type of shape before project, in order to examine whether it is applicable to general tissue. A coarse model is least distortion of an inner side and an outside, and considered that each individual difference of tissue is absorbable.
Modeling cellular signal processing using interacting Markov chains (2004)

Signal processing is an integral part of cell biology. The associated algorithms are implemented by signaling pathways that cell biologists are just beginning to understand and characterize. Our objective in the context of signal processing is to understand these algorithms and perhaps emulate them in other contexts such as communication and speech processing. Towards this end, the paper proposes a new framework for modeling cellular signal processing using interacting Markov chains. The model is presented and preliminary results that validate it are given. Specifically, the example of the mitogen activated protein kinase cascade is examined and model predictions are compared to experimental findings. The model is consistent with the key properties of the cascade, i.e. ultrasensitivity, adaptation, and bistability.
Modulation by 17,20S(OH)2pD of Fibrosis-Related Mediators in Dermal Fibroblast Lines from Healthy Donors and from Patients with Systemic Sclerosis (2021)

We previously demonstrated that the non-calcemic pregnacalciferol (pD) analog 17,20S (OH)<sub>2</sub>pD suppressed TGF-β1-induced type I collagen production in cultured normal human dermal fibroblasts. In the present studies, we examined fibroblasts cultured from the lesional skin of patients with systemic sclerosis (scleroderma (SSc)) and assessed the effects of 17,20S(OH)<sub>2</sub>pD on fibrosis-related mediators. Dermal fibroblast lines were established from skin biopsies from patients with SSc and healthy controls. Fibroblasts were cultured with either 17,20S(OH)<sub>2</sub>pD or 1,25(OH)<sub>2</sub>D<sub>3</sub> (positive control) with/without TGF-β1 stimulation and extracted for protein and/or mRNA for collagen synthesis and mediators of fibrosis (MMP-1, TIMP-1, PAI-1, BMP-7, PGES, GLI1, and GLI2). 1 7,20S(OH)<sub>2</sub>pD (similar to 1,25(OH)<sub>2</sub>D<sub>3</sub>) significantly suppressed net total collagen production in TGF-β1-stimulated normal donor fibroblast cultures and in cultures of SSc dermal fibroblasts. 17,20S(OH)<sub>2</sub>pD (similar to 1,25(OH)<sub>2</sub>D<sub>3</sub>) also increased MMP-1, BMP-7, and PGES and decreased TIMP-1 and PAI1 expression in SSc fibroblasts. Although 17,20S(OH)<sub>2</sub>pD had no effect on Gli1 or Gli2 in SSc fibroblasts, it increased Gli2 expression when cultured with TGF-β1 in normal fibroblasts. These studies demonstrated that 17,20S(OH)<sub>2</sub>pD modulates mediators of fibrosis to favor the reduction of fibrosis and may offer new noncalcemic secosteroidal therapeutic approaches for treating SSc and fibrosis.
Photonic crystal nanocavities and broad-area cavities (2011)

Photonic crystals, in which the refractive index changes periodically, provide an exciting tool for the manipulation of photons that have made substantial progresses in recent years. In this presentation, I will discuss the recent progress of photonic-crystals with regards to two-types of cavities: (i) nanocavities and (ii) broad area cavities.
Modeling Biology using Generic Reactive Animation (2010)

Complex biological systems involve incorporated behaviors of numerous processes, mechanisms and objects. However, experimental analysis, by its nature, divides biological systems into static interactions with little dynamics. To bridge the gap betwee
Effect of scaling copper through-silicon vias on stress and reliability for 3D interconnects (2016)

In this paper, the scaling effect on copper TSV stress and reliability is investigated, focusing on the correlation of microstructure with plasticity and extrusion for 10, 5, and 2µm diameter vias, fabricated by the via middle process. X-ray microdiffraction revealed local plasticity in the tops of the vias for all sizes, and showed that this seemed to depend on the variations in the grain structure. The microstructure showed a tight distribution of grain sizes after the post-plating anneal, but further annealing caused considerable spreads for all via diameters. This trend is consistent with the via extrusion statistics observed, where the absolute values and variation in the extrusion heights increased significantly with annealing. Overall, these results suggest that scaling down TSV dimensions may not improve the stress and reliability behavior, particularly after further annealing at 400°C. Since such annealing processes are required for via-middle fabrication, it seems that via reliability will continue to be a challenge as TSV scaling continues.
Ursodeoxycholyl Lysophosphatidylethanolamid: Ein experimenteller Phospholipid-basierter Ansatz zur Behandlung der nicht-alkoholischen Fettlebererkrankung (2010)

Einleitung: Störungen des hepatischen Lipidmetabolismus mit Fettakkumulation und veränderter Lipidkomposition sind Kennzeichen der nicht-alkoholischen Fettlebererkrankung (NAFLD). In dieser Arbeit wird die Wirkung des Gallensäure-Phospholipid-Konjugates Ursodeoxycholyl Lysophosphatidylethanolamid (UDCA-LPE) in zwei diätetischen Modellen der NAFLD untersucht.
Mechanisms of Oncolysis by Paramyxovirus Sendai (2015)

Some viral strains of the Paramyxoviridae family may be used as anti-tumor agents. Oncolytic paramyxoviruses include attenuated strains of the measles virus, Newcastle disease virus, and Sendai virus. These viral strains, and the Sendai virus in particular, can preferentially induce the death of malignant, rather than normal, cells. The death of cancer cells results from both direct killing by the virus and through virus-induced activation of anticancer immunity. Sialic-acid-containing glycoproteins that are overexpressed in cancer cells serve as receptors for some oncolytic paramyxoviruses and ensure preferential interaction of paramyxoviruses with malignant cells. Frequent genetic defects in interferon and apoptotic response systems that are common to cancer cells ensure better susceptibility of malignant cells to viruses. The Sendai virus as a Paramyxovirus is capable of inducing the formation of syncytia, multinuclear cell structures which promote viral infection spread within a tumor without virus exposure to host neutralizing antibodies. As a result, the Sendai virus can cause mass killing of malignant cells and tumor destruction. Oncolytic paramyxoviruses can also promote the immune-mediated elimination of malignant cells. In particular, they are powerful inducers of interferon and other cytokynes promoting antitumor activity of various cell components of the immune response, such as dendritic and natural killer cells, as well as cytotoxic T lymphocytes. Taken together these mechanisms explain the impressive oncolytic activity of paramyxoviruses that hold promise as future, efficient anticancer therapeutics.
Stability conditioning to enhance read stability 10x in 50nm Al<inf>x</inf>O<inf>y</inf> ReRAM (2013)

This study focuses on read stability after reset in 50nm Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">y</sub> ReRAM. Unstable behaviors are characterized and a 2-part solution to reduce instability from 64 to 6% and read error from 8 to 0.2% is proposed. After conventional reset including verify, (i) a block-level low voltage sealing operation is followed by (ii) a stability check loop.
Assuring virtual network function image integrity and host sealing in Telco cloue (2017)

In Telco cloud environment, virtual network functions (VNFs) can be shipped in the form of virtual machine images and hosted over commodity hardware. It is likely that these VNF images will contain highly sensitive data and mission critical network operations. For this reason, these VNF images are prone to malicious tampering during shipping and even after uploaded to the cloud image database. Furthermore, due to various applications, there is a requirement from mobile network operators to seal VNFs on specific platforms which satisfy certain hardware and software configurations. This requires cloud service providers to introduce some mechanisms to verify VNF image integrity and host sealing before the instantiation of VNFs. In this paper, we present a proof of concept demonstrated with the help of an experimental setup to solve the above-mentioned problems. We also evaluate the performance of the envisioned setup and present some insights on its usability.
Identification of a Microtubule-associated Motor Protein Essential for Dendritic Differentiation (1997)

The quintessential feature of the dendritic microtubule array is its nonuniform pattern of polarity orientation. During the development of the dendrite, a population of plus end-distal microtubules first appears, and these microtubules are subsequently joined by a population of oppositely oriented microtubules. Studies from our laboratory indicate that the latter microtubules are intercalated within the microtubule array by their specific transport from the cell body of the neuron during a critical stage in development (Sharp, D.J., W. Yu, and P.W. Baas. 1995. J. Cell Biol. 130:93- 104). In addition, we have established that the mitotic motor protein termed CHO1/MKLP1 has the appropriate properties to transport microtubules in this manner (Sharp, D.J., R. Kuriyama, and P.W. Baas. 1996. J. Neurosci. 16:4370-4375). In the present study we have sought to determine whether CHO1/MKLP1 continues to be expressed in terminally postmitotic neurons and whether it is required for the establishment of the dendritic microtubule array. In situ hybridization analyses reveal that CHO1/MKLP1 is expressed in postmitotic cultured rat sympathetic and hippocampal neurons. Immunofluorescence analyses indicate that the motor is absent from axons but is enriched in developing dendrites, where it appears as discrete patches associated with the microtubule array. Treatment of the neurons with antisense oligonucleotides to CHO1/MKLP1 suppresses dendritic differentiation, presumably by inhibiting the establishment of their nonuniform microtubule polarity pattern. We conclude that CHO1/MKLP1 transports microtubules from the cell body into the developing dendrite with their minus ends leading, thereby establishing the nonuniform microtubule polarity pattern of the dendrite.
Nanocrystalline Systems For Protection, Detection and Demilitarization. (1995)

Abstract : Ferritin, an ubiquitous biological iron-storage protein molecule, consists of 24 symmetrically related protein subunits forming a near-spherical hollow shell, apoferritin. The central cavity of the apoferritin shell is occupied by an iron core of ferrihydrite or 5Fe2 03. 9 H2O varying in crystallite structure (amorphous or crystalline) depending on the source of the ferritin which is widely distributed in nature (e.g., mammalian spleen, liver, heart or bacterial, plant or fungal ferritin.) Through our experimentation it has been shown not only that the iron (III) core can be photochemically reduced (Fe (II)) in presence of electron donors, but likewise that organic substrates such as oxalate and tartrate can be photo-oxidized, the ferrihydrite core acting as a catalyst, with the concomitant reduction of O2. Laser photolysis studies confirmed the reduction of cytochrome C and viologens photosensitized by ferritin via band-gap excitation. jg p2
Multiphoton microfabrication of conducting polymer-based biomaterials (2015)

We report the application of multiphoton microfabrication to prepare conducting polymer (CP)-based biomaterials that were capable of drug delivery and interacting with brain tissue ex vivo, thereby highlighting the potential of multiphoton lithography to prepare electroactive biomaterials which may function as implantable neural biointerfaces (e.g. electrodes).
Spin-reorientation transition in ɛ-In0.24Fe1.76O3 nanowires (2014)

The magnetic phase transition in ɛ-In0.24Fe1.76O3 nanowires at a temperature of 190 K, which is accompanied by a sharp decrease in the magnetization and coercive force, has been discussed. A mechanism of the observed transition associated with a change in the direction of the easy magnetization axis owing to the competition between single-ion and dipole-dipole magnetic anisotropies has been proposed.
Three Phase SEPIC Based Inverter Employing Reduced Amount of Switches for Renewable Applications (2016)

The SEPIC based inverter with reduced amount of switches has been proposed as an innovative inverter design to reduced cost and complexity.The four switch three phase (FSTP) SEPIC based inverter have less switching losses of the DC-AC conversion system. FSTP inverter operates at half the DC input voltages, so the output line voltage cannot exceed this value. The proposes a design for the FSTP overcome this problems and produced pure sinusoidal without need of filter in output side. The proposed topology produce output line voltage which can be extended up to full value of the DC line voltage. The Fuzzy control is used with proposed topology to ensure the robustness of the system. Fuzzy logic allows, solving difficult simulated problems with many inputs and output variables. The parameters, component ratings, and the operation of the proposed SEPIC inverter is described in this paper. Experiment and simulation shows the effectiveness of the proposed inverter.
A Condensable Amphiphile with a Cleavable Tail as a “Lizard” Template for the Sol−Gel Synthesis of Functionalized Mesoporous Silica (2004)

Use of a dialkoxysilane-containing, condensable alanine amphiphile with a cleavable hexadecyl ester tail (1) as a "lizard" template for sol-gel synthesis results in the formation of a mesoporous silicate (2) whose channels are filled with an organic group of the template. Treatment of 2 with aqueous HCl allows selective cleavage of the ester moiety to leave nanochannels (3) whose surface is densely covered with alanine-CO2H. According to XRD and TEM, 2, on conversion into 3, can preserve its regular hexagonal structure. 3 displays a clear N2 adsorption/desorption isotherm with a BET surface area of 536 m2 g-1. 3 can also adsorb a basic guest such as NH3 up to 0.7 mmol g-1, which is 7 times greater than that observed for mesoporous silica obtained by calcination of 2.
An integrated magnetoresistive read, inductive write high density recording head (1975)

The design, fabrication and performance of an experimental thin film recording head is described which has 25 μm and 125 μm track width magnetoresistive (MR) read elements combined with a single turn thin film inductive write head. The MR read elements are shielded to provide high linear resolution with an equivalent read gap of 1/2 μm and are internally biased by means of a permanent magnet film in the gap. The best head performance with a 0.5 μm air bearing on a high performance disk was: write current of 400 mA peak, isolated pulse readback signal of 40 mV peak per mm of track width at 10 mA sense current, with a 6 db density of 440 flux changes per mm (11 kfci).
Gas-Phase and Surface Chemistry in Electronic Materials Processing. Materials Research Society Symposium Proceedings Held in Boston, Massachusetts on November 29-December 2, 1993. Volume 334 (1994)

The papers are organized in six sections. Part I contains papers on silicon and carbon systems. In addition to papers discussing silicon and silicon oxide deposition it includes several papers on diamond film growth. The chemistry underlying the growth and doping of III-V and II-VI compound semiconductors is covered in Part II together with several studies discussing new precursors. Part III contains papers on metallization. The deposition of dielectric and transitional layers is the topic of Part IV. Par V contains papers on etching of thin films. Finally, Part VI covers special topics, such as deposition on patterned substrates, reactor design, heteroepitaxy and selective epitaxy