gebhart/patrepeval huggingface dataset:
0377 Clinical Pharmacology Of The Dual Orexin Receptor Antagonist Act-541468 In Elderly Subjects (2019)

The orexin system regulates sleep and arousal. Following single-ascending dose (SAD) morning and repeated evening administration of ACT-541468, pharmacokinetics (PK), pharmacodynamics (PD), safety, tolerability, and residual next-day effects were investigated in healthy elderly subjects. Double-blind, placebo-controlled, randomized, SAD study (5, 15, and 25 mg in the morning) in 24 male and female elderly subjects (65-80 years, 6/2 active/placebo per group, 1:1 sex ratio). In a separate study part, 10 subjects (8/2 active/placebo) received 25 mg for 7 days at bedtime. PK, PD (saccadic peak velocity (SPV), adaptive tracking, body sway, Bond and Lader visual analog scales, Karolinska Sleepiness Scale), safety, and tolerability were assessed. Absorption of ACT-541468 was quick, with median maximum plasma concentrations reached at 0.8-1.0 h across the dose range. The geometric mean elimination half-life was 8.5-9.8 h, the area under the curve, and the maximum plasma concentration increased proportionally to the dose administered. Following evening administration of 25 mg for 7 days, no relevant accumulation was observed. In the SAD part, there were no PD effects at 5 mg. At 15 mg, SPV was reduced, returning to baseline after 12 h, while other PD variables showed no effects. At 25 mg, effects on all PD parameters were observed, with an onset ≤ 1 h post-dose and a maximum mean effect at 1-2 h. PD effects returned to baseline 8-12 h post-dose. No next-day residual effects on objective and subjective PD variables were observed when assessments were performed in the next morning after evening administration. The incidence of adverse events in the elderly subjects of this study was lower when compared to young adults in previous studies. ACT-541468 in elderly subjects, both after morning and evening administration, was safe and PK and PD are compatible with a drug for the treatment of insomnia. Clemens Muehlan and Jasper Dingemanse are employees at Idorsia, the sponsor of the study. The investigators Rob Zuiker, Sander Brooks and Joop van Gerven are employees of CHDR.
Bis(4-nitrophenyl)tetrafluorosulfuranes:  Synthesis, Isomerization and Structural Characterization (1999)

Due to their octahedral symmetry, otherwise not available for carbon based chemistry, hypervalent sulfur fluorides are very attractive as structural building blocks for functional organic materials. Direct fluorination offers a convenient access to multigram quantities of highly stable bis(4-nitrophenyl)tetrafluorosulfurane. Guided by molecular modeling, a novel catalytic process was devised to isomerize the predominantly formed cis isomer to the pure trans isomer.
High-Resolution Electron Microscopy of Crystal Lattice of Titanium-Niobium Oxide (1971)

The detailed structure within the two-dimensional projection of the unit cell of a Ti2Nb10O29 crystal, showing the arrangement of the metal atoms, has been revealed by careful use of a high-resolution electron microscope. The image shows good agreement with the model of the structure deduced from x-ray diffraction studies.
Binding Sites for Epidermal Growth Factor in Human Fetal Membranes (1984)

The present study demonstrates that human fetal membranes bind 125I-epidermal growth factor (125I-EGF), with chorion binding more than amnion. The chorion binding was also higher than that by decidua, but lower than in placenta. The lower binding by chorion compared to placenta was entirely attributable to a lower number of available EGF receptors and not to lower affinity. Chorion and placenta , but not amnion or decidua, from Cesarean section bound significantly more 125I-EGF when compared to tissues obtained after vaginal delivery. The binding of 125I-EGF to chorion exhibited dependency on time, temperature of incubation, pH of the incubation media, and amount of chorion protein. The 125I-EGF was not degraded during the binding reaction with chorion. The binding was specific in that unlabeled EGF inhibited 125I-EGF binding in a dose-dependent manner, whereas very high concentrations of other unlabeled hormones and growth factors had minimal effects on 125I-EGF binding. When some of these other hormones were tested for binding as tracers (125I-hCG, [3H]prostaglandin E1 and F2 alpha), neither chorion, amnion, decidua, nor placenta specifically bound these ligands. The 125I-EGF specific binding to chorion was saturable and a Scatchard plot of this data was curvilinear, which appears to be due to negative cooperativity. The apparent dissociation constant calculated from the initial slope of the plot was 0.20 nM, which is in excellent agreement with the concentration of unlabeled EGF required for half maximal inhibition of 125I-EGF binding, 0.26 nM. Autoradiography at the light microscope level revealed the presence of silver grains in amnion and chorion only when excess unlabeled EGF addition was withheld. The quantification of grains revealed the presence of a significantly (P less than 0.01) greater number of grains in chorion than in amnion, supporting the conclusion of the binding data. The physiological significance of EGF binding to fetal membranes and decidua is not known, but the considerable amount of EGF binding reported here suggests that they are target tissues for EGF.
Factors Affecting the Damping Capacity of TiC Particle Reinforced Zinc-22 Aluminum Composites (1997)

Damping behavior of eutectoid zinc-aluminum composites was studied in the 25 to 33O°C temperature range using a low-frequency torsion pendulum. In this study the internal friction was affected by changes in microstructure and by the amount of cold work prior to testing. The highest damping was obtained for a composite with 15% titanium carbide (TiC) particles, a fine lamellar microstructure, and after being cold worked 20%. A high-temperature (HT) internal friction peak at a temperature just below the eutectoid transformation temperature was observed in the composite materials, and in the annealed base alloys cold worked prior to testing. The authors believe this HT peak is associated with recrystallization of the matrix prior to the eutectoid transformation.
Negative Bleaching Photoresist (BLEST) For Mid-UV Exposure (1988)

The design and preparation of a mid-UV negative bleaching photoresist (BLEST) are described. This two-component resist system is composed of a cresol novolac resin and 4,4&apos;-diazido-3,3&apos;-dimethoxybiphenyl. BLEST is a negative working resist which has the advantage of alleviating optical interference effects caused by reflection from the topograhic features on the substrate surface. The resist is characterized by its photobleaching controllability which helps incident UV light to penetrate more deeply, thus realizing a high aspect ratio. BLEST was exposed to mid-UV light and developed in a tetramethylammoniumhydroxide aqueous solution. The sensitivity of the resist was about 150 mJ/cm2 and contrast was 1.7. A good resist profile was obtained by printing on a Perkin-Elmer Micralign 500 system.
The importance of investment feasibility analysis (2010)

Purpose The purpose of this paper is to look at the importance of investment feasibility analysis. Design/methodology/approach The paper addresses the question of whether a planned course of action is likely to achieve individual or enterprise objectives, given the available resources and specific constraints. Key issues are the legal, physical, and financial feasibility of a project proposal. Feasibility typically addresses the issue of the most appropriate use for a particular site, the most appropriate site for a predetermined use, or the most appropriate outlet for investment funds. Findings Even though changes in the economy have increased risk or lowered returns, the investment market continues to devise innovative and attractive investment strategies and the determined investor keeps searching for profitable projects. Originality/value The paper gives investment principles that should be taken into consideration and will be of interest to those in a similar field.
Reductive deposition of Au3+(aq) on oxidized silicon surfaces (2000)

X-ray photoelectron spectroscopy (XPS) is used to determine the oxidation state of gold deposited from an aqueous solution of AuCl 4 - on to various oxidized surfaces of silicon. Although the observed Au4f signal decreased with the thickness of the oxide layer, the oxidation state of Au was determined as 0 for all the samples analyzed. From the angular dependence of the Si2p and Au4f signals it was determined that Au is deposited on top of the oxidized surfaces of metallic silicon. It is postulated that from an aqueous solution of AuCl 4 - , gold would deposit in its zerovalent form on to any surface due to its large and positive electrochemical reduction potential (ε ° red (Au 3+ /Au) = +1.50 V) and the substrate plays a role only in providing active deposition sites. To further support the proposal, it is shown that the same process takes place even in inert and hydrophobic polypropylene substrates. Similarly, it is also shown that more gold deposits if the surface of the polypropylene is made less hydrophobic (but probably more active) via the industrially used corona discharge treatment.Key words: XPS, gold, electroless deposition, oxidized silicon surface.
Coverage-driven Automated Compiler Test Suite Generation (2003)

The paper presents a novel approach to automated compiler test suite generation based on the source level specification. Several coverage criteria are introduced. The application of the proposed methodology to testing the realistic programming language is discussed.
Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia (2022)

Natural killer (NK) cells are innate lymphoid cells that eliminate cancer cells, produce cytokines, and are being investigated as a nascent cellular immunotherapy. Impaired NK cell function, expansion, and persistence remain key challenges for optimal clinical translation. One promising strategy to overcome these challenges is cytokine-induced memory-like (ML) differentiation, whereby NK cells acquire enhanced antitumor function after stimulation with interleukin-12 (IL-12), IL-15, and IL-18. Here, reduced-intensity conditioning (RIC) for <i>HLA</i>-haploidentical hematopoietic cell transplantation (HCT) was augmented with same-donor ML NK cells on day +7 and 3 weeks of N-803 (IL-15 superagonist) to treat patients with relapsed/refractory acute myeloid leukemia (AML) in a clinical trial (NCT02782546). In 15 patients, donor ML NK cells were well tolerated, and 87% of patients achieved a composite complete response at day +28, which corresponded with clearing high-risk mutations, including <i>TP53</i> variants. NK cells were the major blood lymphocytes for 2 months after HCT with 1104-fold expansion (over 1 to 2 weeks). Phenotypic and transcriptional analyses identified donor ML NK cells as distinct from conventional NK cells and showed that ML NK cells persisted for over 2 months. ML NK cells expressed CD16, CD57, and high granzyme B and perforin, along with a unique transcription factor profile. ML NK cells differentiated in patients had enhanced ex vivo function compared to conventional NK cells from both patients and healthy donors. Overall, same-donor ML NK cell therapy with 3 weeks of N-803 support safely augmented RIC haplo-HCT for AML.
Die μ3‐(η3Cη2O)‐Brücke, ein neuartiger Koordinationstyp in der Strukturchemie von Carbonylmetallverbindungen (1979)

Der erste Carbonylniobcluster, zugleich das erste Beispiel für eine Verbindung mit „end on”︁ sowie doppelt „side on”︁ koordiniertem CO‐Liganden [Typ ( 1 )], wurde durch Einwirkung von Sonnenlicht auf den gut zugänglichen Komplex ( 2 ) erhalten. Die Struktur von ( 3 ) ist röntgenographisch gesichert. magnified image
Application heartbeats for software performance and health (2010)

Adaptive, or self-aware, computing has been proposed to help application programmers confront the growing complexity of multicore software development. However, existing approaches to adaptive systems are largely ad hoc and often do not manage to incorporate the true performance goals of the applications they are designed to support. This paper presents an enabling technology for adaptive computing systems: Application Heartbeats. The Application Heartbeats framework provides a simple, standard programming interface that applications can use to indicate their performance and system software (and hardware) can use to query an application's performance. The PARSEC benchmark suite is instrumented with Application Heartbeats to show the broad applicability of the interface and an external resource scheduler demonstrates the use of the interface by assigning cores to an application to maintain a designated performance goal.
A circuit construction of parallel ring-line rat-race circuit with very loose coupling utilizing CRLH-TLs (2014)

This paper treats parallel ring-line rat-race circuits with very loose coupling utilizing composite right-/left-handed transmission lines (CRLH-TLs). We have already reported the parallel ring-line rat-race circuits composed of four CRLH-TLs and two right-handed transmission lines (RH-TLs), and successfully designed −20dB rat-race circuits with broadband characteristics. In this paper, to reduce the number of CRLH-TLs we propose the parallel ring-line rat-race circuit composed of two CRLH-TLs with electrical length of −90 degrees and four RH-TLs with 90 degrees. As a result of designing the circuit at 4GHz, a relative bandwidth of about 27% can be obtained for the -20dB rat-race circuit. Furthermore, high power durability for the trial −20dB circuit has been also demonstrated.
Antibacterial ability and hemocompatibility of graphene functionalized germanium (2016)

Germanium (Ge), as an elemental semiconductor material, has been an attractive candidate for manufacturing semiconductor microelectronic device. In the present investigation, to improve the biocompatibility of Ge-based device, graphene film is directly deposited on the Ge surface with different coverage area by controlling the growth time. Compared to bare Ge, the presence of graphene film entitles Ge with satisfactory antibacterial ability against Staphylococcus aureus (S.aureus), and acceptable antibacterial ability against Escherichia coli (E. coli). Meanwhile, antibacterial efficiency closely correlates with coverage area of graphene film, and larger graphene coverage always leads to better antibacterial performance. The underlying mechanism is thought to be the integrative action of phospholipids disturbance and electron extraction at the interface between graphene and biomembrane. Meanwhile, the electron extraction action would further lead to the activation of platelet. This study might provide some new insights into the relationship between antibacterial ability and hemocompatibility based on graphene functionalized biomedical device.
Interactions acoustiques entre transducteurs de type flextenseur (1994)

En acoustique sous-marine, il existe actuellement un interet grandissant pour les systemes sonar actifs basse frequence, destines a la detection longue portee de sous-marins discrets. Pour ces sonars, les reseaux compacts de flextenseurs constituent un systeme d'emission interessant, car ils delivrent une forte puissance acoustique en basse frequence. Malheureusement, il se manifeste dans ces reseaux des interactions acoustiques fortes difficiles a modeliser, ce qui constitue un obstacle majeur a la conception d'antennes de flextenseurs. C'est pourquoi la recherche presentee propose une methode de calcul specifiquement adaptee aux reseaux de flextenseurs, s'appuyant sur des modeles elements finis et sur une hypothese simplificatrice originale, qui privilegie la prise en compte precise des interactions acoustiques avec les voisins immediats. La mise en œuvre du modele sur un reseau prototype prouve son interet numerique par rapport a des methodes classiques, pour une tres bonne precision de resultats
High Ethylene‐Yield Oxidative Dehydrogenation of Ethane Using Sulfur Vapor as a “Soft” Oxidant (2020)

Abstract Ethylene remains one of the most valuable chemical feedstocks. Currently the industrial conversion of ethane to ethylene is achieved largely by steam cracking. The catalytic, highly exothermic oxidative dehydrogenation (ODH) of ethane with O 2 is a challenging alternative that has been extensively studied on the laboratory scale. Here we investigate the possibility of using disulfur (S 2 ) vapor as a thermodynamically “soft” oxidant for catalytically converting ethane to ethylene (“SODH”). Investigating a series of four catalysts we report a maximum ethylene yield of 76 % over an earth‐abundant FeS x ‐based catalyst (maximum 90.2 % C 2 H 4 selectivity at 820 °C). Yield and selectivity are stable for 50 hours on stream. The SODH rate law is 1 st order in ethane and order in S 2 , supporting a proposed Mars van Krevelen‐like mechanism at temperatures &lt;700 °C. Furthermore, conversion and selectivity become insensitive to catalyst identity at temperatures &gt;860 °C, suggesting the intrusion of radical pathways.
CeO2-Doped Hf0.5Zr0.5O2 Ferroelectrics for High Endurance Embedded Memory Applications (2022)

We demonstrate ferroelectric switching in CeO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> doped Hf <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.5</inf> Zr <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.5</inf> O <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> (HZCO) thin films and their applications for back-end-of-line (BEOL) compatible embedded memories. At low cerium oxide doping concentrations (2.0 - 5.6 mol%), the polar orthorhombic phase is stabilized after annealing at temperatures below 400°C. HZCO ferroelectrics show reliable switching characteristics beyond 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sup> cycles in TiN/HZCO/TiN (MFM) capacitors, several orders magnitude higher than the identically processed Hf <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.5</inf> Zr <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.5</inf> O <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> (HZO) capacitors, without sacrificing polarization and retention. We also report enhanced endurance (> 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10</sup> cycles) in HZCO metal-ferroelectric-insulator-semiconductor (MFIS) stacks, which is promising for ferroelectric FET memory applications.
REGOLITH-LANDFORM MAPPING OF THE SHOALHAVEN RIVER DELTA AND HINTERLAND, NSW: TOWARDS A MODEL FOR LANDSCAPE CHANGE AND MANAGEMENT (2002)

Coastal landscapes are dynamic, hosting a range of ongoing regolith and landscape processes. Regolith-landform mapping has the potential to represent the landscape features and their attributes in these areas, but to date there has been little detailed regolith-landform mapping of coastal areas. As a result the applications of these maps for representing, understanding and managing these areas has been largely overlooked.
ChemInform Abstract: All‐Conjugate Block Copolymers (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Impact of extrinsic and intrinsic parameter variations on CMOS system on a chip performance (2003)

The yield of high performance CMOS digital circuits is demonstrated to be significantly influenced by the magnitude of critical path delay fluctuations due to both extrinsic and intrinsic parameter variations, as well as the number of critical paths in a system on a chip. To evaluate the impact of these parameter variations, a static CMOS critical path delay distribution is developed and analyzed by employing rigorously derived device and circuit models that enable projections for future technology generations. Increasing the supply voltage and, consequently, power dissipation, the distribution is shifted to satisfy the nominal critical path delay for a desired yield. For the 50 nm technology generation, results indicate supply voltage and power dissipation increases of 14-24% and 31-53%, respectively, for extrinsic parameter standard deviations ranging from (a) 5% for effective channel length and 0% for gate oxide thickness and channel doping concentration to (b) 10% for effective channel length and 5% for gate oxide thickness and channel doping concentration.
Novel Heparanase-Inhibiting Antibody Reduces Neointima Formation (2006)

Basic fibroblast growth factor (bFGF), stored bound to heparan sulfate proteoglycans in the extracellular matrix (ECM) of the arterial media, may initiate smooth muscle cell (SMC) proliferation after coronary intervention, thus contributing to restenosis. bFGF mobilization from ECM stores after injury may be induced by platelet degranulation products such as heparanase. Therapies aimed at the inhibition of bFGF release and activation may assist in prevention of restenosis. To test this theory, we first examined the mobilization and activation of bFGF in the arterial media by platelet-derived heparanase. Heparanase, locally delivered to the rat carotid artery, was found to release bFGF and induce substantial SMC proliferation in the absence of actual vascular injury. An antibody that neutralizes heparanase was then developed and evaluated in a rat carotid balloon injury model. Local delivery of anti-heparanase IgG was found to inhibit bFGF release by approximately 60% ( p < 0.001) at 4 d; this correlated with the significant reduction in neointima formation observed at 14 d (intimal area/medial area: control 1.3 +/- 0.3, anti-heparanase 0.35 +/- 0.12, p < 0.0001). Platelet-derived heparanase is therefore likely to be important in initiating events leading to restenosis via bFGF mobilization. Furthermore, heparanase neutralization may assist in the prevention of restenosis following vascular injury.
Infant cry classification integrated ANC system for infant incubators (2013)

The high noise level inside the infant incubator results in numerous adverse health effects for premature newborns and the active noise control (ANC) systems are developed to reduce the noise. This paper proposes an infant cry classification integrated ANC system for infant incubators. The developed system can dramatically reduce the harmful noise level, and the integrated infant cry detector and analyzer can monitor the infants' physical conditions. The infant cry signals are picked up and detected by the same microphones used by the ANC system, the cry signal's features are extracted and then recognized. The simulation and experiment results show that the cry recognition of specific infants yielded promising results.