gebhart/patrepeval huggingface dataset:
A novel heuristic for topology planning and evolution of optical mesh networks (2002)

We consider the problem of determining an optimal facilities route topology for an optical mesh-restorable network. In general, there will be a set of existing rights-of-way for cable ducts etc. and a limited number of new acquisition prospects for topology evolution. The enhancement of network connectivity is of particular interest in a mesh-based transport network, but new rights-of-way can be very expensive. The interaction between the edge costs and capacity savings in a mesh network is also different than in prior topology design problems. We describe a three-stage heuristic based on a particular hypothesis about the problem. The heuristic runs quickly and produces solutions that typically cannot be improved upon by the optimal formulation in 6 to 12 hours and are within 8% of optimal in cases where the optimum reference could be solved. The heuristic also provides a fairly tight upper bound to help in solving the complete problem.
In vivo Bromodeoxyuridine Incorporation in Normal Rat Liver: Immunohistochemical Detection of Streaming Cells and Measurement of Labelling Indices. (1994)

The aim of the present study was to determine if normal liver cell kinetics can be evaluated using bromodeoxyuridene (BrdU) as the label. BrdU was injected intraperitoneally into 10 male adult rats, 5 were sacrified after 1hr, and the remainder after 30 days. The livers were fixed in 70% ethanol, embedded in paraffin and histological slides were prepared. The labelled nuclei were revealed using indirect immunoperoxidase staining and easily counted by light microscopy. One hr after labelling, labelled hepatocytes and littoral cells were detected within 164±12.3μm and 161±13μm respectively from the portal tract rim. After 30 days, both cell types reached the respective distances of 290±14.6μm and 294±17.7μm. Their respective displacement velocities were 4.2μm/d and 4.3μm/d. These results were identical to those we obtained using tritiated thymidine. This laboratory method provides a useful and simpler alternative method to tritiated thymidine.
Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis (2015)

This review did not reveal any methods for the prediction of progression in AIS that could be recommended for clinical use as diagnostic criteria.
Electrostatic Spraying of Food‐Grade Organic and Inorganic Acids and Plant Extracts to Decontaminate Escherichia coli O157:H7 on Spinach and Iceberg Lettuce (2012)

Electrostatic spraying is an emerging technique that can be adopted to improve the distribution and application of antimicrobials during fresh produce sanitation. Relatively simple and quick, the process can access most/all parts of produce surface and offer protection from food pathogens. The use of malic and lactic acids with or without grape seed extract can serve as effective antimicrobials when sprayed electrostatically, lowering the risk from postcontamination issues with spinach and iceberg lettuce. This application technology can be extended to improve the commercial food safety of other produce, fruits, poultry, and meat.
Figure S1 from Gene Copy Number Estimation from Targeted Next-Generation Sequencing of Prostate Cancer Biopsies: Analytic Validation and Clinical Qualification (2023)

&lt;p&gt;Plotting a) the median spread of coverage per-gene, from the pooled reference data and b) the per-gene standard deviations for duplicated samples shows that some genes are less reliable than others.&lt;/p&gt;
Urolithiasis, Endourology and Laparoscopy (2006)

No AccessJournal of UrologyUrological survey1 Jul 2006Urolithiasis, Endourology and Laparoscopy Ralph V. ClaymanM.D. Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2006.03.020AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 2006FiguresReferencesRelatedDetails Volume 176Issue 1July 2006Page: 146-148 Advertisement Copyright & Permissions© 2006MetricsAuthor Information Ralph V. Clayman More articles by this author Expand All Advertisement PDF DownloadLoading ...
Anthracycline metabolites from baumycin-producing Streptomyces sp. D788. II. New anthracycline metabolites produced by a blocked mutant strain RPM-5. (1993)

A daunorubicin-blocked mutant strain RPM-5 derived from a new baumycin-producing Streptomyces sp. D788 accumulated a major precursor metabolite D788-1 (10-carboxyl-13-deoxocarminomycin) and nine minor metabolites in the culture broth. Five among them were new with a substituent at C-10 or the altered side chains at C-9. Isolation, purification and identification of all anthracycline metabolites produced by strain RPM-5 are described with their antitumor activities against L1210 cells.
Efficacy of Metmyoglobin and Hemin as a Catalyst of Lipid Peroxidation Determined by Using a New Testing System (2007)

A new quantitative approach to investigate the capability of iron heme complexes (HEM), metmyoglobin and hemin, to catalyze lipid peroxidation was elaborated. The oxidation of methyl linoleate in micellar solutions was used as a testing model. The key point was the determination of the rate of free radical generation, RIN, calculated from the rate of oxygen consumption. The HEM catalytic activity was characterized by two independent parameters: by reactivity and by its resistance to degradation. Both parameters were found to be pH-dependent. The reactivity was expressed as the effective rate constant for the reaction of HEM with lipid hydroperoxide. The resistance to degradation was characterized by the rate of the decrease in RIN with time and also by the regeneration coefficient, which shows how many active free radicals can be generated by one molecule of HEM. Both Hemin and metMB were found to be very effective catalysts even at nanomolar concentrations. The effective regeneration of active forms of HEM was observed. The catalytic activity of HEM was rapidly reduced with time. The kinetic scheme of the process under consideration was suggested, and this was applied for kinetic computer simulations.
Flexible epoxy novolac coatings: Use of cardanol‐based flexibilizers (2017)

ABSTRACT Flexible epoxy novolac coatings were developed by reacting an epoxy novolac resin, poly[(phenylglycidyl ether)‐ co ‐formaldehyde] (PPGEF) with an amine curing agent, 4,4′‐diamino‐3,3′‐dimethyldicyclohexyl methane (BMCHA), cardanol based reactive diluent (Cardolite NC‐513) and two different cardanol‐based flexibilizers (Cardolite NC‐514 and Cardolite NC‐547). The flexibilizer content was varied from 5 to 10% by weight of the resin. These resins were coated onto the stainless steel panels and tested for their gloss, cross‐hatch adhesion, falling weight impact resistance, flexibility, abrasion, scratch hardness, solvent scrub resistance, and chemical resistance. The thermo‐mechanical properties of these coatings were determined by TGA, DSC, DMTA, and tensile strength measurements. The cryofractured specimens were subjected to SEM analysis. The influence of structural differences of two flexibilizers on the coating properties was investigated. These coatings exhibited excellent properties and have great potential in industrial applications. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 44920.
Detection of Enterovirus-Specific RNA Sequences in Explanted Myocardium Biopsy Specimens from Patients with Dilated or Ischemic Cardiomyopathy (1995)

Enteroviral RNA (EV-RNA) was detected in endomyocardial tissue by means of retrotranscription and polymerase chain reaction (RT-PCR) followed by slot-blot hybridization. The myocardial biopsy specimens studied were taken at the time of heart transplantation from 15 patients with dilated cardiomyopathy (DCM) and from 10 patients with ischemic cardiomyopathy (ICM). Specimens from 18 (72%) of the 25 patients were positive for EV-RNA, whereas no control specimens (myocardial specimens from 29 healthy organ donors and atrial specimens from 15 patients with acute myocardial infarction treated by anatomic bypass) yielded evidence of EV-RNA. The rates of EV-RNA detection for the two groups requiring heart transplantation did not differ significantly (66.7% vs. 80.0%; chi 2 test). Our findings support a link between enteroviral infection in both DCM and ICM and suggest a pathogenic role for the enteroviruses.
The narcissistic leader: world-renowned and quite arrogant (2009)

In a position of leadership, people suffering from this kind of disorder become fixated on power, status, prestige, and superiority. They overvalue their personal worth, arguing that, as exceptional people they deserve special privileges and prerogatives. They act in a grandiose, haughty way, expect special favors, flout conventional rules, and feel entitled; they're unempathetic, inconsiderate to others, exploitative, and unconstrained by objective reality.(Kets de Vries, 2006, p. 22)
Supplementary Table 1 from Sym004: A Novel Synergistic Anti–Epidermal Growth Factor Receptor Antibody Mixture with Superior Anticancer Efficacy (2023)

Supplementary Table 1 from Sym004: A Novel Synergistic Anti–Epidermal Growth Factor Receptor Antibody Mixture with Superior Anticancer Efficacy
Aflibercept in the Treatment of Diabetic Macular Edema: A Review and Consensus Paper (2017)

Consensus was reached among experts on how to best treat patients with DME with aflibercept.
Effect of Mg-, Zr-, and Ta-doping on scintillation properties of Gd/sub 2/SiO/sub 5/:Ce crystal (2003)

We developed Mg-, Zr-, and Ta-doped GSO:Ce scintillator materials to improve scintillation properties for medical imaging scanners such as a positron emission tomograph (PET). The crystals of (Mg, Zr or Ta)/sub y/ -doped Gd/sub 2-x/SiO/sub 5/:Ce/sub x/ (x=0.5, y=0.0002%/spl sim/0.031%) were grown. The scintillation decay curve, rise time, light output, and optical transmittance of these crystals were measured. Improvement of optical transparency was found for GSO:Ce, Zr.
Supplementary Figures from Cytosine Methylation Profiles as a Molecular Marker in Non–Small Cell Lung Cancer (2023)

Supplementary Figures from Cytosine Methylation Profiles as a Molecular Marker in Non–Small Cell Lung Cancer
Synthesis and characterization of square-planar iron(II) complexes with dianionic tetraaza macrocyclic ligands and their novel derivatives (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and characterization of square-planar iron(II) complexes with dianionic tetraaza macrocyclic ligands and their novel derivativesDennis P. Riley, John A. Stone, and Daryle H. BuschCite this: J. Am. Chem. Soc. 1977, 99, 3, 767–777Publication Date (Print):February 1, 1977Publication History Published online1 May 2002Published inissue 1 February 1977https://pubs.acs.org/doi/10.1021/ja00445a018https://doi.org/10.1021/ja00445a018research-articleACS PublicationsRequest reuse permissionsArticle Views366Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Exercise-induced electrocardiographic changes in patients with chronic respiratory diseases: differential diagnosis by 99mTc-tetrofosmin SPECT. (2003)

The incidence of myocardial ischemia as determined by perfusion SPECT was low in CRD patients with positive exercise-induced ECG changes. On the other hand, RV overload was observed in most such cases. Cardiac perfusion SPECT is a useful technique to evaluate cardiac ischemia and RV overload simultaneously. CPET with 12-lead ECG monitoring is necessary in CRD patients before respiratory rehabilitation. Further examination for ischemia should be done if positive ST depression is found.
Mechanical electrostatically actuated optic switch for N /spl times/ N cross-connect array (2001)

Summary form only given. The non-stopping growth of fiber optic networks has stimulated a great interest in optical switching. Micromachined optical switches are under thorough investigation due to their potentially low insertion losses and crosstalk. Electrostatic actuators are featured with low power consumption, high switching speed and small geometries. We propose an electrostatically driven 1 /spl times/ 2 switch by making use of planar waveguide SiON technology.
Global Meta-Analysis of Urine Microbiome: Colonization of PAH-degrading bacteria among bladder cancer patients (2022)

Abstract Background The application of next generation sequencing techniques has enabled characterization of urinary tract microbiome. Although many studies have demonstrated associations between the human microbiome and bladder cancer, they have not always reported consistent results, thereby necessitating cross-study comparisons. Thus, the fundamental questions remain how we can utilize this knowledge. The aim of our study was to examine for disease-associated changes in urine microbiome communities globally utilizing machine learning algorithm. The results were further validated using our own prospectively collected urine of bladder cancer patients. Results Our study included 129 bladder cancer urine samples, and 60 healthy controls across four different countries. At a meta-analysis false discovery rate (FDR) of 0.01, we identified a total of 97/548 genera to be differentially abundant in the BCa microbiome compared to healthy patients. Overall, while the differences in diversity metrics were clustered around the country of origin (Kruskal Wallis, P &lt; 0.001), collection methodology was a driver of microbiome composition. When assessing dataset from the China, Hungary and Croatia, ML data demonstrated no discrimination capacity to distinguish between BCa and healthy (AUC 0.577). However, inclusion of samples with catheterized urine only improved the diagnostic accuracy of prediction for BCa to AUC 0.995, with precision recall AUC = 0.994. Through elimination of contaminants associated with collection methodology among all cohorts, our study identified increased abundance of polycyclic aromatic hydrocarbon (PAHs) degrading bacteria Sphingomonas, Acinetobacter, Micrococcus, and Ralstonia consistently present in BCa patients. Conclusions The microbiota of the bladder cancer population may be a reflection of PAH exposure from smoking, environmental pollutants and ingestion. Presence of PAHs in urine of bladder cancer patients may allow for a unique metabolic niche, and provide necessary metabolic resources where other bacteria are not able to flourish. Furthermore, we found that while compositional differences associated with geography more than disease, many are driven by collection methodology.
Calcium sensing receptor gene: Analysis of polymorphism frequency (1997)

The role that the Calcium Sensing Receptor (CASR) plays in extracellular calcium regulation had been ascertained through studies of inactivating as well as activating mutations of CASR gene in a number of multiplex families. We have extended these observations to a polymorphism analysis of the intercellular domain of CASR in a cohort of healthy young women. The results demonstrate significant allelic polymorphism as a result of nonconservative changes at two specific sites. Further studies will be required to determine what, if any, relationship this may have to CASR phenotype.
ChemInform Abstract: Supported Gold Nanoparticles Catalyzed cis‐Selective Semihydrogenation of Alkynes Using Ammonium Formate as the Reductant. (2016)

Abstract An efficient procedure is developed for the gold‐catalyzed semihydrogenation of alkynes.
Improving the efficiency of the Diels–Alder process by using flow chemistry and zeolite catalysis (2016)

The industrial application of the Diels–Alder reaction for the synthesis of (hetero)cyclic compounds constitutes an important challenge. To tackle the reagent instability problems and corresponding safety issues, the use of a high-pressure and zeolite catalysed microreactor process is presented.
Conservation of the Drosophila lateral inhibition pathway in human lung cancer: A hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression (1997)

The achaete-scute genes encode essential transcription factors in normal Drosophila and vertebrate nervous system development. Human achaete-scute homolog-1 (hASH1) is constitutively expressed in a human lung cancer with neuroendocrine (NE) features, small cell lung cancer (SCLC), and is essential for development of the normal pulmonary NE cells that most resemble this neoplasm. Mechanisms regulating achaete-scute homolog expression outside of Drosophila are presently unclear, either in the context of the developing nervous system or in normal or neoplastic cells with NE features. We now provide evidence that the protein hairy-enhancer-of-split-1 (HES-1) acts in a similar manner as its Drosophila homolog, hairy, to transcriptionally repress achaete-scute expression. HES-1 protein is detected at abundant levels in most non-NE human lung cancer cell lines which lack hASH1 but is virtually absent in hASH1-expressing lung cancer cells. Moreover, induction of HES-1 in a SCLC cell line down-regulates endogenous hASH1 gene expression. The repressive effect of HES-1 is directly mediated by binding of the protein to a class C site in the hASH1 promoter. Thus, a key part of the process that determines neural fate in Drosophila is conserved in human lung cancer cells. Furthermore, modulation of this pathway may underlie the constitutive hASH1 expression seen in NE tumors such as SCLC, the most virulent human lung cancer.
Evaluation of polymer solubility and cavitation on ultrasound-polymer synergy (2002)

Poly(propylacrylic acid) is a pH-sensitive membrane disruptive polymer designed to release therapeutic molecules from endosomes to the cell cytoplasm before degradation. In mildly acidic environments, the polymer becomes more hydrophobic and less soluble in aqueous medium. Previous research has demonstrated the capacity of polyelectrolytes and therapeutic ultrasound to synergistically disrupt red blood cell membranes, resulting in hemolysis [Mourad (2000)]. In this investigation, the ability of therapeutic ultrasound and PPAA to disrupt cell membranes and deliver fluorescently labeled polymer to the cell cytoplasm was demonstrated. The ultrasound/polymer synergy was dependent upon the solubility of PPAA and acoustic cavitation activity. The solubility of PPAA in phosphate buffered saline was quantified by measuring variations in liquid/gas interfacial tension with polymer concentration and acidity. Reductions of surface tension up to 28% were measured using the Wilhemy plate technique. Acoustic cavitation activity was measured using a passive cavitation detection scheme, quantified, and correlated with the number of fluorescent cells. This study demonstrates the potential of combining therapeutic ultrasound and membrane-disruptive polymers for drug delivery.
ChemInform Abstract: Silyl Group‐Transfer‐Mediated Serial Michael Additions. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Au-silica core/shell hybrid nanoparticles furnished with CdTe nanocrystals for enhanced plasmon-exciton interactions (2010)

To date extensive research efforts have confirmed that optical properties of bulk semiconductors and metals are substantially modified when they are transformed into nano-dimensions. For example, metal nanoparticles with dimensions less than hundred nanometers strongly oscillate at a specific resonance frequency to generate localized surface plasmons depending on their size. This creates strongly localized electric fields in the close proximity of the metal nanoparticles under external excitation. Similarly, because of the size effect, semiconductor quantum dot nanocrystals (NCs), with dimensions less than 10 nanometers, feature highly tunable absorption and emission characteristics. High levels of brightness and photostability, and broad excitation range with sharp emission spectra make these NCs ideal candidates as active materials in light emitting diodes and solar cells, and as fluorescent labels in bioimaging. This paper presents the synthesis and characterization of a new set of CdTe NC decorated, Au-silica core/shell hybrid nanoparticles with silica shell thicknesses controlled and tuned by synthesis.This paper demonstrates that Au-silica core/shell nanoparticles can successfully assemble CdTe nanocrystals right on their silica shells for enhanced plasmon-exciton interactions, while avoiding the problems of lacking control in spacing and limited film thickness.
Building the Sun4Cast System: Improvements in Solar Power Forecasting (2017)

Abstract As integration of solar power into the national electric grid rapidly increases, it becomes imperative to improve forecasting of this highly variable renewable resource. Thus, a team of researchers from the public, private, and academic sectors partnered to develop and assess a new solar power forecasting system, Sun4Cast. The partnership focused on improving decision-making for utilities and independent system operators, ultimately resulting in improved grid stability and cost savings for consumers. The project followed a value chain approach to determine key research and technology needs to reach desired results. Sun4Cast integrates various forecasting technologies across a spectrum of temporal and spatial scales to predict surface solar irradiance. Anchoring the system is WRF-Solar, a version of the Weather Research and Forecasting (WRF) numerical weather prediction (NWP) model optimized for solar irradiance prediction. Forecasts from multiple NWP models are blended via the Dynamic Integrated Forecast (DICast) System, which forms the basis of the system beyond about 6 h. For short-range (0–6 h) forecasts, Sun4Cast leverages several observation-based nowcasting technologies. These technologies are blended via the Nowcasting Expert System Integrator (NESI). The NESI and DICast systems are subsequently blended to produce short- to midterm irradiance forecasts for solar array locations. The irradiance forecasts are translated into power with uncertainties quantified using an analog ensemble approach and are provided to the industry partners for real-time decision-making. The Sun4Cast system ran operationally throughout 2015 and results were assessed. This paper analyzes the collaborative design process, discusses the project results, and provides recommendations for best-practice solar forecasting.