gebhart/patrepeval huggingface dataset:
Descending-Order Clique-Based Task Scheduling for Active Measurements (2007)

Network active measurement is a required process in high performance networks for efficient QoS provisioning. The contention of the active measurement processes in a network can jeopardize measurement and overload network and computation resources. In this paper, we propose a novel scheduling algorithm to resolve contention of measurement tasks. Our proposed scheme is based on graph-coloring theory and uses a descending order of a clique (a set of contending nodes) in a graph. We evaluate our proposed scheme under different measurement task assignment scenarios. The simulation results demonstrate that our proposed scheme produces effective contention resolution and decreases the number of assigned colors.
Homomorphic Speech Analysis-Synthesis (1978)

Abstract : This work is summarized in the following projects: homomorphic speech analysis-synthesis, enhancement of degraded speech, time-varying linear predictive coding of speech signals, and digital seismic signal processing.
Consensus Recommendations to Accelerate Clinical Trials for Neurofibromatosis Type 2 (2009)

Both phase 0 and phase II NF2 trials are near-term options for NF2 clinical trials. The number of NF2 patients in the population remains limited, and successful recruitment will require ongoing collaboration efforts between NF2 clinics.
ChemInform Abstract: Receptors That Assemble Themselves (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Oncogene Mimicry as a Mechanism of Primary Resistance to BRAF Inhibitors (2014)

Despite the development of potent RAF/mitogen-activated protein kinase (MAPK) pathway inhibitors, only a fraction of BRAF-mutant patients benefit from treatment with these drugs. Using a combined chemogenomics and chemoproteomics approach, we identify drug-induced RAS-RAF-MEK complex formation in a subset of BRAF-mutant cancer cells characterized by primary resistance to vemurafenib. In these cells, autocrine interleukin-6 (IL-6) secretion may contribute to the primary resistance phenotype via induction of JAK/STAT3 and MAPK signaling. In a subset of cell lines, combined IL-6/MAPK inhibition is able to overcome primary resistance to BRAF-targeted therapy. Overall, we show that the signaling plasticity exerted by primary resistant BRAF-mutant cells is achieved by their ability to mimic signaling features of oncogenic RAS, a strategy that we term "oncogene mimicry." This model may guide future strategies for overcoming primary resistance observed in these tumors.
Helicobacter pyloriinfection in 1st degree relatives of Chinese gastric cancer patients (2005)

This study identifies the patterns and risk factors for H. pylori in gastric cancer relatives, which may shed light on the evolving epidemiology of H. pylori infection in Chinese patients.
Abstract 19266: Identifying Patients at High Risk for Readmission following Treatment for Acute Myocardial Infarction: a Data-Centric Approach (2014)

Background: The American College of Cardiology Patient Navigator Program (ACC-PNP) was launched to address the growing need for a reduction in 30-day readmission rates following acute myocardial infarction (AMI). To facilitate identification of patients at greatest risk and target for intervention, we developed a risk score that runs in real-time based on a predictive model derived from electronic health records (EHR). Methods: To develop a comprehensive assessment of risk factors contributing to 30-day readmission following AMI, we assessed Medicare penalty eligible patients discharged from our institution with a primary diagnosis of AMI between Jan 1, 2010 and June 30, 2012. EHR-derived variables (retrospective and prospectively derived) from 780 eligible patients were used to automatically compute likelihoods of 30-day readmissions. Patients were randomly divided into a derivation (60%) and validation (40%) cohort. Logistic regression was employed, using the LASSO technique for variable selection. Mode...
Body-loss for popular thin smart phones (2013)

In this contribution, an investigation of the radio performance of recent popular phones has been done. The antenna performance has been evaluated with the newly agreed phantom head-hand measurements of the mobile antenna efficiency. It has been observed that the newer generation thin smart phones have worse performance than the classical phones and more surprisingly there is a loss in performance between generation of the same brand of smart phone. The effect of the performance variation between phones has been illustrated by calculating the coverage area for the voice service for Denmark with data from all mobile operators for the best and worst performing ones.
ChemInform Abstract: Practical Routes Toward the Synthesis of 2‐Halo‐ and 2‐Alkylamino‐4‐pyridinecarboxaldehydes. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
VALIDITY OF NORMALIZED INDEX OF HEMOLYSIS IN PEDIATRIC MECHANICAL CIRCULATORY ASSIST DEVICES (2006)

Mechanical blood trauma is one of the major concerns in development and clinical use of mechanical circulatory assist devices (MCAD). Even moderate hemolysis, which is not an immediate threat to renal function, is an important warning sign of other blood cell potential damage which can cause serious complications (platelet activation, WBC dysfunction, etc.). The common parameter used to assess the hemolytic potential of MCADs in vitro is plasma free hemoglobin (plfHb) released from overstretched or fragmented RBCs. It is often represented by a Normalized Index of Hemolysis (NIH) which is proportional to the rate of plfHb, volume of circulating blood, hematocrit, and inversely proportional to flow rate. We hypothesized that due to complex nature of cellular hemodynamics inside a MCAD, this index might not be scalable to the small MCADs required for pediatric applications, which exhibit flow rates as low as 0.2 - 0.5 L/min. We tested this hypothesis in vitro using a BioMedicus pediatric pump and bovine blood. We found that while an increase in plfHb during a given time was much lower at a flow rate of 0.3 L/min then at flow rate of 2.0 L/min, the computed NIH was several times greater for the lowest flow rate compared to the highest. In general, while the plfHb level linearly increased with an increase in flow rate, NIH increased exponentially with decreasing flow rates. This study motivates the development of revised normalization formulae that may account for small scale devices.
Gentrifying Atlanta: Investor Purchases of Rental Housing, Evictions, and the Displacement of Black Residents (2021)

Displacement of Black communities through gentrification is a major concern among policymakers, community groups, and advocates. This research investigates whether investor purchases of multifamily rental housing predict evictions and the displacement of Black residents from Atlanta, Georgia, between 2000 and 2016. In a series of quantitative analyses, we identify the financialization of rental housing and subsequent eviction-led displacement as key neighborhood-level processes in racial transition and the gentrification of Atlanta. We find that eviction judgments grew by 8% annually in the Atlanta region, and same-site apartment sale prices increased by an average of $5.5 million. Investor purchases of rental housing in a neighborhood predict a spike in eviction judgments in the same year, and presage racial transition. Neighborhoods with investor purchases of apartment buildings lose 166 Black residents and gain 109 White residents over a 6-year period compared with adjacent neighborhoods with no investor purchases.
Effect of an in vivo environment on the strength of bone cement (1979)

Bar-shaped polymethylmethacrylate test specimens removed from rabbits after implantation for times up to 26 months showed a significant change in fracture stress as determined by three-point bending in the period between 12 and 26 months. There were no adverse findings in the tissue which developed around the bone-cement test bars.
Anaesthesia and efficacy of hyperbaric oxygen in radiation therapy (1980)

We have previously reported a marked enhancement of efficacy of hyperbaric oxygen to decrease the TCD50 for fractionated irradiation of mammary carcinomas (MDAH–MCaIV) in C3H mice by pentobarbital anaesthesia (0.05 mg/g IP) (Suit et al., 1979). The mechanism for this effect has not been elucidated. In this issue Biaglow and Yau describe the results of relevant experiments which show a marked inhibition of cell respiration of V79 lung cells and Ehrlich ascites tumour cells by pentobarbital.
Alpharetroviral Self-inactivating Vectors: Long-term Transgene Expression in Murine Hematopoietic Cells and Low Genotoxicity (2012)

Comparative integrome analyses have highlighted alpharetroviral vectors with a relatively neutral, and thus favorable, integration spectrum. However, previous studies used alpharetroviral vectors harboring viral coding sequences and intact long-terminal repeats (LTRs). We recently developed self-inactivating (SIN) alpharetroviral vectors with an advanced split-packaging design. In a murine bone marrow (BM) transplantation model we now compared alpharetroviral, gammaretroviral, and lentiviral SIN vectors and showed that all vectors transduced hematopoietic stem cells (HSCs), leading to comparable, sustained multilineage transgene expression in primary and secondary transplanted mice. Alpharetroviral integrations were decreased near transcription start sites, CpG islands, and potential cancer genes compared with gammaretroviral, and decreased in genes compared with lentiviral integrations. Analyzing the transcriptome and intragenic integrations in engrafting cells, we observed stronger correlations between in-gene integration targeting and transcriptional activity for gammaretroviral and lentiviral vectors than for alpharetroviral vectors. Importantly, the relatively "extragenic" alpharetroviral integration pattern still supported long-term transgene expression upon serial transplantation. Furthermore, sensitive genotoxicity studies revealed a decreased immortalization incidence compared with gammaretroviral and lentiviral SIN vectors. We conclude that alpharetroviral SIN vectors have a favorable integration pattern which lowers the risk of insertional mutagenesis while supporting long-term transgene expression in the progeny of transplanted HSCs.
Comparison of theory and simulation for a radially symmetric transit-time oscillator (2003)

Summary form only given, as follows. The transit-time effect in a coaxial structure has been used by Arman (1996) to design low impedance high power microwave devices that use no externally-generated magnetic fields and have no confining foils. Luginsland et al. (1997) have developed simple one-dimensional (1-D) non-linear circuit equations that are solved numerically to estimate key device characteristics. This paper extends this approach to analytically estimate the values of the free parameters used in the circuit equations, compares the analytical values to similar values derived from two-dimensional (2-D) particle-in-cell simulations, and compares the results of numerical solutions of the 1-D circuit equations and 2-D simulations. It is shown that the non-linear relationship between voltage and current emission in a space charge limited diode drives an RF oscillation whose frequency is determined by the resonant characteristics of the annular diode cavity; damping and electromagnetic field saturation results from a combination of transit time effects and electron bunching due to the non-linear electron emission characteristics of the space charge limited diode. The results from the 1-D analysis and 2-D particle-in-cell simulation are shown to be in excellent agreement.
Multigenotype HCV-NS3 recombinant vaccinia viruses as a model for evaluating cross-genotype immunity induced by HCV vaccines in the mouse (2006)

Surrogate infections with HCV-recombinant vaccinia virus (HCV-rVV) are a standard method to test the efficacy of hepatitis C virus (HCV) vaccine candidates in the mouse model. We established a panel of 16 HCV-rVV expressing the nonstructural protein 3 (NS3) of HCV genotypes 1a, 1b, 2, 3 and 4. Mice immunized with recombinant NS3 protein derived from HCV genotype 1b were challenged with the rVV. rVV-titers decreased up to 54-fold after subtype 1b challenge and up to 8.5-fold after subtype 1a challenge. No changes were detected for genotyüpes 2, 3, or 4. Our model is a convenient and reliable tool to analyze the induction of cross-genotype immunity by experimental vaccination of mice.
The CoRoT satellite in flight: description and performance (2009)

Context. CoRoT is a space telescope dedicated to stellar seismology and the search for extrasolar planets. The mission is led by the CNES in association with French laboratories and has a large international participation. The European Space Agency (ESA), Austria, Belgium, and Germany contribute to the payload, and Spain and Brazil contribute to the ground segment. Development of the spacecraft, which is based on a PROTEUS low earth orbit (LEO) recurrent platform, commenced in October 2000, and the satellite was launched on December 27, 2006. Aims. The instrument and platform characteristics prior to launch have been described in ESA publication (SP-1306). In the present paper we explain the behaviour in flight, based on raw and corrected data. Methods. Five runs have been completed since January 2007. The data used here are essentially those acquired during the commissioning phase and from a long run that lasted 146 days. These enable us to give a complete overview of the instrument and platform behaviour for all environmental conditions. The ground based data processing is not described in detail because the most important method has been published elsewhere. Results. We show that the performance specifications are easily satisfied when the environmental conditions are favourable. Most of the perturbations, hence data corrections, are related to LEO perturbations: high energy particles inside the South Atlantic Anomaly (SAA), eclipses and temperature variations, and line of sight fluctuations due to the attitude control system. Straylight due to the reflected light from the earth, which is controlled by the telescope and baffle design, appears to be negligible.
Fabrication of Planar Colloidal Clusters with Template-Assisted Interfacial Assembly (2015)

The synthesis of nanoparticle clusters, also referred to as colloidal clusters or colloidal molecules, is being studied intensively as a model system for small molecule interactions as well as for the directed self-assembly of advanced materials. This paper describes a technique for the interfacial assembly of planar colloidal clusters using a combination of top-down lithographic surface modification and bottom-up Langmuir-Blodgett deposition. Micrometer sized polystyrene latex particles were deposited onto a chemically modified substrate from a decane-water interface with Langmuir-Blodgett deposition. The surface of the substrate contained hydrophilic domains of various size, spacing, and shape, while the remainder of the substrate was hydrophobic. Particles selectively deposited onto hydrophilic regions from the decane-water interface. The number of deposited particles depended on the size of each patch, thereby demonstrating that tuning cluster size is possible by engineering patch geometry. Following deposition, the clusters were permanently bonded with temperature annealing and then removed from the substrate via sonication. The permanently bonded planar colloidal clusters were stable in an aqueous environment and at a decane-water interface laden with isotropic colloidal particles. The method is a simple and fast way to synthesize colloidal clusters with few limitations on particle chemistry, composition, and shape.
B18 Human induced neural stem cells as model to study the neural development in huntington’s disease (2018)

<h3>Background</h3> Induced pluripotent stem cell (iPSC) technology offers the possibility to generate patient-specific iPS cells and to enable the development of <i>in vitro</i> HD models that more accurately reflect the human disease. HD patients’ iPSC can be propagated indefinitely and differentiated into any cell type in the human body even functional neuronal cells, holding a great potential for disease modeling and drug screening. <h3>Aims</h3> 1) obtain neuronal cell lines starting from the patient’s fibroblasts using the iPSC technology 2) study the disease development 3) find compounds able to improve the HD phenotype. <h3>Methods</h3> Patient’s skin fibroblasts were reprogrammed into iPSCs through a virus-free protocol. All iPSC lines were characterized for their stemness and pluripotency, both <i>in vitro</i> through embryoid bodies formation and <i>in vivo</i> through teratoma formation assay. A protocol was optimized for iPCs neural differentiation (Rosati et al., under revision). We may obtain a neural population of astrocytes, oligodendrocytes. <h3>Results</h3> Fibroblasts obtained from two JHD patients, two adult HD patients and one healthy donor were reprogrammed into iPSC. iPSC neuralization has been performing to obtain neurosphere lines which will be analyzed at morphological and molecular level to underline functional and biochemical differences linked with the juvenile and adult Huntington’s disease. <h3>Conclusion</h3> NPCs were obtained from one JHD and a healthy donor. These ‘induced’ NPCs differentiated in three neural lineages: neurons, astroglia and oligodendrocytes. These cells can be studied for their morphological and functional characteristics to comprehend how the development of neural cells is impaired in Huntington’s disease.
New insights in acute kidney failure in the critically ill (2012)

The term acute kidney injury (AKI) has been recently coined by a large panel of international experts in place of the former expression "acute renal failure". This change has been motivated by a double intention: first it served to definitely find a conventional definition for acute changes of renal function, previously lacking in the medical community. In fact, any attempt to compare scientific papers and different centres experiences on AKI was essentially impossible. The second aim was to remark that this syndrome is characterised by a spectrum of progressive damage, from mild creatinine increase to renal injury to a more severe form, failure: this important concept should increase clinicians awareness to every form of renal dysfunction, even milder ones, in order to improve epidemiologic analyses, potentially preventing eventual AKI progression and finally helping standardisation of medical and supportive therapy. This review will describe such "new era" of critical care nephrology by presenting current literature (and its many controversies) about AKI diagnosis, physiopathology and management.
Automatic transcription of polyphonic music using the multiresolution Fourier transform (2002)

The application of the multiresolution Fourier transform (MFT) has been investigated for the purpose of analyses of polyphonic musical signals, and its potential for achieving reliable automatic transcription has been shown. This paper presents improved transcription algorithms which use the MFT coefficients for the recognition of a single polyphonic musical instrument. The algorithms have been tested on acoustic piano signals. Results show that reliable detection can be achieved if some limitations are imposed on the playing performance. Good results are attained in more complicated performances than those reported previously.
Flap Models in the Rat: A Review and Reappraisal (1992)

The laboratory rat has long provided plastic surgical investigators a model to study many aspects of flap physiology. Clinical advances in reconstructive surgery have succeeded or preceded experimental work, setting the stage for further advances. We have critically reviewed all reports of flap models in the laboratory rat. This has begun with simple skin flaps designed on various areas of the body and continued with a review of free-tissue transfer models. Because of the multitude of as yet unanswered questions remaining, the laboratory rat will invariably continue to be widely used as an investigatory source in this area. This report should allow investigators to select more easily reliable, reproducible experimental models, and, one hopes, to streamline their investigative efforts.
Alternative Syntheses of (S)-cEt-BNA: A Key Constrained Nucleoside Component of Bioactive Antisense Gapmer Sequences (2014)

Approaches to the synthesis of the constrained 5-methyluracil nucleoside (S)-cEt-BNA, a key "gapmer" unit in a number of biologically relevant antisense oligonucleotides, are described using 5-methyluridine as starting material. In the shorter synthesis, a nine-step linear sequence afforded a O-protected (S)-cEt-BNA consisting of a [2.2.1]dioxabicycloheptane core in 7% overall yield. A competing reaction in an intramolecular cyclization of a tosylate led to a bicyclic oxetane.
Data from K562/GM-CSF Immunotherapy Reduces Tumor Burden in Chronic Myeloid Leukemia Patients with Residual Disease on Imatinib Mesylate (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Chronic myeloid leukemia (CML) can be responsive to T-cell–mediated immunity. K562/granulocyte macrophage-colony stimulating factor (GM-CSF) is a GM-CSF producing vaccine derived from a CML cell line that expresses several CML-associated antigens. A pilot study was developed to determine if K562/GM-CSF immunotherapy could improve clinical responses to imatinib mesylate (IM) in patients with chronic myeloid leukemia.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Patients with chronic phase CML who achieved at least a major cytogeneic response but remained with persistent, measurable disease despite one or more years on imatinib mesylate were eligible. Each was given a series of four vaccines administered in three-week intervals, with or without topical imiquimod, while remaining on a stable dose of imatinib mesylate. CML disease burden was measured serially before and after vaccination.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Nineteen patients were vaccinated, with a median duration of previous imatinib mesylate therapy of 37 (13–53) months. Mean PCR measurements of &lt;i&gt;BCR-ABL&lt;/i&gt; for the group declined significantly following the vaccines (&lt;i&gt;P&lt;/i&gt; = 0.03). Thirteen patients had a progressive decline in disease burden, 8 of whom had increasing disease burden before vaccination. Twelve patients achieved their lowest tumor burden measurements to date following vaccine, including seven subjects who became PCR-undetectable.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; K562/GM-CSF vaccine appears to improve molecular responses in patients on imatinib mesylate, including achieving complete molecular remissions, despite long durations of previous imatinib mesylate therapy. Clin Cancer Res; 16(1); 338–47&lt;/p&gt;&lt;/div&gt;