gebhart/patrepeval huggingface dataset:
Evaluation of the Respiratory Function in Intensive Care: Prospects and Hopes in Medical Instrumentation. Auswertung der Lungenfunktion auf der Intensivstation: Perspektiven und Hoffnungen der biomedizinischen Technik (1983)

Article Evaluation of the Respiratory Function in Intensive Care: Prospects and Hopes in Medical Instrumentation. Auswertung der Lungenfunktion auf der Intensivstation: Perspektiven und Hoffnungen der biomedizinischen Technik was published on January 1, 1983 in the journal Biomedical Engineering / Biomedizinische Technik (volume 28, issue 7-8).
STAT3 signaling is required for anti-OX40/TGF-β receptor blockade-mediated regression of large established tumors (2013)

Meeting abstracts OX40 (CD134, TNFRSF4), a member of the tumor necrosis factor receptor (TNFR) superfamily is expressed on activated CD4+ and CD8+ T cells. In pre-clinical tumor models, agonist OX40 antibody (αOX40) therapy is often successful at treating small tumors but is less effective once
Race Differences in the Association of Oxidative Stress With Insulin Sensitivity in African‐ and European‐American Women (2011)

Excessive metabolism of glucose and/or fatty acids may impair insulin signaling by increasing oxidative stress. The objective of this study was to examine the association between insulin sensitivity and protein carbonyls, a systemic marker of oxidative stress, in healthy, nondiabetic women, and to determine if the relationship differed with race. Subjects were 25 African-Americans (AA, BMI 28.4 ± 6.2 kg/m(2), range 18.8-42.6 kg/m(2); age 33.1 ± 13.5 years, range 18-58 years) and 28 European-Americans (EA, BMI 26.2 ± 5.9 kg/m(2), range 18.7-48.4 kg/m(2); age 31.6 ± 12.4 years, range 19-58 years). Insulin sensitivity was determined using an intravenous glucose tolerance test incorporating [6,6-(2)H(2)]-glucose, and a two-compartment mathematical model. Multiple linear regression results indicated that insulin sensitivity was inversely associated with protein carbonyls in AA (standardized regression coefficient -0.47, P < 0.05) but not EA (0.01, P = 0.945), after adjusting for %body fat. In contrast, %body fat was significantly and positively associated with insulin sensitivity in EA (-0.54, P < 0.01) but not AA (-0.24, P = 0.196). Protein carbonyls were associated with free fatty acids (FFA) in AA (r = 0.58, P < 0.01) but not EA (r = -0.11, P = 0.59). When subjects were divided based on median levels of fasting glucose and FFA, those with higher glucose/FFA concentrations had a significantly greater concentration of circulating protein carbonyls compared to those with lower glucose/FFA concentrations (P < 0.05). These results suggest that oxidative stress independently contributes to insulin sensitivity among AA women. Further, this association in AA may be mediated by circulating FFA and/or glucose.
Les politiques de la réorganisation administrative (2017)

Créer de nouvelles agences, fusionner des services, mettre en place des guichets uniques : pourquoi, en France comme à l’étranger, les gouvernants ne cessent-ils de modifier les périmètres et les juridictions des bureaucraties bouleversant ainsi la division du travail étatique ? C’est à ces questions que cherche à répondre le numéro de la Revue française de science politique “Politiques de l’organisation. Les nouvelles divisions du travail étatique”*, dirigé Philippe Bezes et Patrick Le Lidec, tous deux chercheurs au Centre d’études européennes de Sciences Po.
Data from Aristolochic Acid in the Etiology of Renal Cell Carcinoma (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Background:&lt;/b&gt;&lt;i&gt;Aristolochia&lt;/i&gt; species used in the practice of traditional herbal medicine contains aristolochic acid (AA), an established human carcinogen contributing to urothelial carcinomas of the upper urinary tract. AA binds covalently to genomic DNA, forming aristolactam (AL)–DNA adducts. Here we investigated whether AA is also an etiologic factor in clear cell renal cell carcinoma (ccRCC).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Methods:&lt;/b&gt; We conducted a population-based case–control study to investigate the linkage between &lt;i&gt;Aristolochia&lt;/i&gt; prescription history, cumulative AA consumption, and ccRCC incidence in Taiwan (5,709 cases and 22,836 matched controls). The presence and level of mutagenic dA-AL-I adducts were determined in the kidney DNA of 51 Taiwanese ccRCC patients. The whole-exome sequences of ccRCC tumors from 10 Taiwanese ccRCC patients with prior exposure to AA were determined.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Cumulative ingestion of more than 250 mg of AA increased risk of ccRCC (OR, 1.25), and we detected dA-AL-I adducts in 76% of Taiwanese ccRCC patients. Furthermore, the distinctive AA mutational signature was evident in six of 10 sequenced ccRCC exomes from Taiwanese patients.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; This study strongly suggests that AA contributes to the etiology of certain RCCs.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Impact:&lt;/b&gt; The current study offers compelling evidence implicating AA in a significant fraction of the RCC arising in Taiwan and illustrates the power of integrating epidemiologic, molecular, and genetic data in the investigation of cancer etiology. &lt;i&gt;Cancer Epidemiol Biomarkers Prev; 25(12); 1600–8. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Introduction of a Dedicated Circulation Phantom for Comprehensive In Vitro Analysis of Intravascular Contrast Material Application (2008)

We developed a flow phantom with physiologic circulation parameters for measurement of contrast enhancement. The phantom is suitable for further evaluation of CM injection protocols for pulmonary and aortic enhancement.
Susceptibility of melanized and nonmelanized Cryptococcus neoformans to the melanin-binding compounds trifluoperazine and chloroquine (1996)

Cryptococcus neoformans is an opportunistic fungal pathogen which becomes heavily melanized in the presence of phenolic substrates such as L-dopa. Various drugs are known to bind to melanin with high affinity, including the antipsychotic agent trifluoperazine and the antimalarial agent chloroquine. We hypothesized that drugs which bind melanin may have different toxicities for melanized and nonmelanized C. neoformans cells. The effects of trifluoperazine and chloroquine or C. neoformans were determined by measuring cell viability after exposure to these drugs. Cell viability was measured by CFU determination and flow cytometry with propidium iodide staining. Melanized cells were more susceptible than nonmelanized cells to the fungicidal effects of trifluoperazine. Chloroquine had no fungicidal effect on either melanized or nonmelanized C. neoformans under the conditions studied. Flow cytometry of trifluoperazine-treated C. neoformans cells stained with the mitochondrial stain dihydrorhodamine 123 revealed fluorescence changes consistent with mitochondrial damage. Our results indicate that melanized and nonmelanized C. neoformans cells can differ in susceptibility to certain drugs and suggest that strategies which target melanin may be productive for antifungal-drug discovery.
Essential Role of Vascular Endothelial Growth Factor and Flt-1 Signals in Neointimal Formation After Periadventitial Injury (2004)

Inflammatory changes mediated by VEGF and Flt-1 signals play an important role in the pathogenesis of neointimal formation after cuff-induced periadventitial injury. VEGF might promote neointimal formation by acting as a proinflammatory cytokine.
Expression of ErbB receptors and their cognate ligands in gastric and colon cancer cell lines. (2009)

This study profiles the expression of ErbB receptors and their cognate ligands in gastric and colon cancer cells. These findings might lay the basis for the development of ErbB pathway-directed therapeutics for gastrointestinal cancer.
Lactase persistence genotypes and malaria susceptibility in Fulani of Mali (2011)

Plasmodium falciparum parasitaemia in asymptomatic Fulani is more common in individuals with lactase non-persistence genotypes, but this difference is not statistically significant. The potential immunoprotective properties of dietary cow milk as a reason for the partial malaria resistance of Fulani warrant further investigation.
Synthesis of Block Copolymers Based on the Alternating Anionic Copolymerization of Styrene and 1,3-Cyclohexadiene (2004)

A series of poly(1,3-cyclohexadiene-alt-styrene)-containing block copolymers that exhibited predictable molecular weights and narrow molecular weight distributions were synthesized with various 1,3-cyclohexadiene contents (13−57 mol %). In situ FTIR spectroscopy in combination with the Mayo−Lewis graphical method was employed to determine the reactivity ratios for the anionic copolymerization of styrene and 1,3-cyclohexadiene. The reactivity ratios for 1,3-cyclohexadiene and styrene were 0.022 and 0.024, respectively, which indicated the formation of an alternating copolymer. The alternating copolymers served as suitable precursors for chemical modification and were either quantitatively aromatized or hydrogenated in a controlled fashion. The thermal stabilities of the modified copolymers were determined, and as expected, the hydrogenated copolymers exhibited improved thermal stability compared to that of poly(1,3-cyclohexadiene-alt-styrene)-containing block copolymers. However, the aromatized copolymers unexpectedly exhibited reduced thermal stability in both nitrogen and oxygen environments due to the introduction of labile benzylic hydrogens in the repeating unit.
Design and Fabrication of Optically Pumped Hybrid Silicon-AlGaInAs Evanescent Lasers (2006)

We present the design and fabrication of a novel laser structure, the hybrid silicon evanescent laser. This structure utilizes offset AlGaInAs quantum wells (QWs) bonded to a silicon waveguide. With this structure, the optical mode is predominantly confined in the passive silicon waveguide and is evanescently coupled to the AlGaInAs strained QWs. The optimal design of the optical waveguide for delivering sufficient optical gain to reach the lasing threshold, while confining most of the optical mode in the silicon waveguide, for efficiently coupling the output power into silicon passive devices, is described. The silicon waveguide is fabricated on a silicon-on-insulator (SOI) wafer using a CMOS-compatible process, and is subsequently bonded with the AlGaInAs QW structure using low temperature O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> plasma-assisted wafer bonding. We demonstrate optically pumped silicon evanescent lasers operating continuous wave (CW) up to 60degC. The lasers emit a wavelength of 1.5 mum with a minimum threshold of 23 mW and a maximum single-sided fiber-coupled CW output power of 4.5 mW at the room temperature
Grasping Mechanisms With Self-Centering and Force-Balancing Characteristics (2005)

This paper presents grasping mechanism configurations that are self-centering with balanced reaction forces, and develops the design principles, models, and analysis methods of achieving these characteristics in compliant mechanisms. The configurations emulate the self-centering and balanced actuation force characteristics exhibited by hydraulic disc-brake systems. Purely mechanical grasping systems, in which both the mechanism and the object being grasped are rigidly attached to ground, require 2 degrees of freedom in the grasping mechanism. It is shown that compliant configurations can exhibit the balanced-force behavior as well as rigid-link mechanisms.
Induction of hyperresponsivity to LPS by Porphyromonas gingivalis in gingival epithelium (2021)

Abstract Chronic periodontitis (CP) is an inflammatory disease of the tooth supporting tissue developed in response to formation of the dysbiotic biofilm on the subgingival tooth surface. Although exacerbated inflammation leads to the alveolar bone destruction and may cause tooth loss the molecular basis of CP initiation and progression remains elusive. The control over the inflammatory reaction and homeostasis can be efficiently restored by the negative regulators of TLRs signaling pathways, such as MCPIP-1, which is constitutively expressed in gingival keratinocytes and prevents the hyporesponsiveness in the gum. Here we found that inflammophilic periodontal species influence stability of MCPIP-1 leading to aggravated response of the epithelium to proinflammatory stimulation. We identified that among enzymes secreted by those pathogenic species, gingipains – cysteine proteases from Porphyromonas gingivalis play a crucial role. Their proteolytic activity leads to a rapid degradation of MCPIP-1 exacerbating inflammatory response induced by endotoxin. Taken together, we showed the novel mechanism of corruption of inflammatory signaling by periodontal pathogens indicating new possibilities for treatment of this chronic disease.
Colorimetric Detection of Catalytic Reactivity of Nanoparticles in Complex Matrices (2015)

There is a need for new methodologies to quickly assess the presence and reactivity of nanoparticles (NPs) in commercial, environmental, and biological samples since current detection techniques require expensive and complex analytical instrumentation. Here, we investigate a simple and portable colorimetric detection assay that assesses the surface reactivity of NPs, which can be used to detect the presence of NPs, in complex matrices (e.g., environmental waters, serum, urine, and in dissolved organic matter) at as low as part per billion (ppb) or ng/mL concentration levels. Surface redox reactivity is a key emerging property related to potential toxicity of NPs with living cells, and is used in our assays as a key surrogate for the presence of NPs and a first tier analytical strategy toward assessing NP exposures. We detect a wide range of metal (e.g., Ag and Au) and oxide (e.g., CeO2, SiO2, VO2) NPs with a diameter range of 5 to 400 nm and multiple capping agents (tannic acid (TA), polyvinylpyrrolidone (PVP), branched polyethylenimine (BPEI), polyethylene glycol (PEG)). This method is sufficiently sensitive (ppb levels) to measure concentrations typically used in toxicological studies, and uses inexpensive, commercially available reagents.
Weak Localization and Electron–Electron Interaction Effects in Indium Zinc Oxide Films (2007)

Electron weak localization (WL), electron–electron (el–el) interaction and electron–phonon (el–ph) scattering effects on the transport properties have been investigated for two to three-dimensional indium zinc oxide films. The temperature T dependence of the electron inelastic scattering rate 1/τ in of two-dimensional films has been deduced from magnetoconductance data. The rate 1/τ in well fits the sum of el–el and el–ph inelastic scattering rates, 1/τ in = 1/τ in,el–el + 1/τ in,el–ph . Using the free electron model to determine the diffusion constant, we have obtained the effective electron mass m * ≈0.55 m 0 by fitting the theory for 1/τ in,el–el to data at sufficiently low temperatures. Under a high magnetic field applied to suppress WL, the Hall coefficient varies, independently of the dimensionality, with temperature by about a two times larger rate than that of resistance. This result agrees well with the theory of Al'tshuler, Aronov, and Lee. At temperatures above ≈10 K, the T dependence of the inverse of mobility 1/µ is well described by the Grüneisen–Bloch formula with the use of the Debye temperature Θ D ≈750–760 K. The el–ph coupling constant λ el–ph ≈1.1–1.3 has been obtained from the combination of data on τ in ( T ), 1/µ( T ), m * , and Θ D .
Twolcatheter technique for uterine fibroid embolisation (1999)

SummaryThis paper describes a method of uterine artery embolisation (UAE) using bilateral femoral artery punc tures and two separate catheters for selective catheterisation of the uterine arteries Bilateral uterine artery catheterisation was performed from the contralateral common femoral arteries The two catheters are placed within the uterine arteries prior to arteriography Simultaneous arteriography was performed before and after embolisation In some cases, simultaneous embolisation was performed by sepa rate physician operators To date, l 15 patients have been treated The first four had unilateral femoral puncture All the subsequent patients were treated with bilateral femoral puncture The emboltsation was successful bilat erally in 113 patients Unilateral embolisation was successful in one patient, with only one patent uterine vessel The procedure failed in one patient, despite patent uterine arteries bilaterally A total of 226 femoral punctures were used in this group of patients There were no puncture-site complications We conclude that bilateral femoral puncture as a method of UAE is an effective alternative approach that may have distinct advantages over unilateral puncture.
Development of a Flex Fuel Vehicle: Impact on Powertrain's Design and Calibration (2010)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The benefits of running on ethanol-blended fuels are well known, especially global CO₂ reduction and performances increase. But using ethanol as a fuel is not drawbacks free. Cold start ability and vehicle autonomy are appreciably reduced. These two drawbacks have been tackled recently by IFP and its partners VALEO and Cristal Union. This article will focus on the second one, as IFP had the responsibility to design the powertrain of a fully flex-fuel vehicle (from 0 to 100% of ethanol) with two main targets: reduce the fuel consumption of the vehicle and maintain (at least) the vehicle performances. Using a MPI scavenging in-house concept together with turbocharging, as well as choosing the appropriate compression ratio, IFP managed to reach the goals. Thanks to the adaptation of the inlet manifold, the intake camshaft as well as the piston and con-rod coupling, the 2L engine with a compression ratio of 10.5 delivers with RON 95 unleaded fuel a maximum torque of 290 Nm constant between 2000 rpm and 3500 rpm, and 142 kW at 5500 rpm. But the output reaches with ethanol-blended fuels 350 Nm between 2000 rpm and 3500 rpm, and 150 kW at 5500 rpm, this from 20% to 100% of ethanol. Such performances made it possible to change the gearbox ratios in order to reduce the fuel consumption. The combination of intake camshaft design, variable valve timing and increased compression ratio also improves engine efficiency at part load. Compared to the standard engine, the BSFC's improvement reaches 7% at 2000 rpm and 2 bar BMEP. The complete adapted powertrain and engine control unit are now mounted in a vehicle and the calibration task is taking place, on the basis of test bench results. Vehicle results should be available for the coming autumn.&lt;/div&gt;&lt;/div&gt;
Contribution of neural elements to thoracic stability (2016)

Sectioning of canal elements was found to cause a measurable increase in ROM. Although nonviable tissues were tested, living tissues are also likely to contribute to spinal stability.
Immunogenicity of tisagenlecleucel in relapsed/ refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL) and diffuse large B-cell lymphoma (DLBCL) patients. (2018)

3044 Background: Tisagenlecleucel, a chimeric antigen receptor (CAR) T-cell therapy, contains a murine single chain variable fragment (mCAR19) binding domain. Humoral immunity to anti-mCAR19 had no impact on safety or efficacy in pediatric r/r B-ALL patients (pts) (Mueller ASH 2017); immunogenicity in r/r DLBCL has not been studied. Methods: Tisagenlecleucel immunogenicity was measured in r/r B-ALL (ELIANA [NCT02435849, n = 75]; ENSIGN [NCT02228096, n = 29]) and r/r DLBCL (JULIET [NCT02445248, n = 99]) ≤ 12 months after infusion. Cellular immunity was measured in PBMCs and tested for mCAR19 peptide-activated T cell responses by stimulated intracellular interferon-gamma production. Anti-mCAR19 antibodies (Ig) were measured by flow cytometry at baseline and after treatment. Treatment-induced Ig was defined as the ratio of postbaseline Ig levels to baseline. The impact of preexisting and treatment-induced Ig and T-cell activation on cellular kinetics, efficacy and safety were determined. Results: 84.6% of r/r B-ALL and 91.4% of r/r DLBCL pts had preexisting humoral immunogenicity. Treatment-induced humoral immunogenicity occurred in 34.6% of r/r B-ALL and 5% of r/r DLBCL pts. No relationship was found between tisagenlecleucel expansion (AUC0-28d) and preexisting humoral responses in r/r B-ALL (r2= 0.002) or r/r DLBCL (r2= 0.008), or treatment-induced humoral responses in r/r B-ALL (r2= 0.006). Results for Cmax were similar. Treatment induced humoral responses did not impact expansion or persistence of CARs in B-ALL, but sample size prevented correlation analysis in DLBCL as only 5% of pts had treatment-induced Ig. Preexisting humoral immunity did not appear to impact transgene persistence, duration of response, event-free survival or safety in either indication. T-cell responses were consistent over time with net responses < 1% at baseline and postinfusion for the majority of pts. T-cell responses did not appear to impact transgene expansion or persistence or pt outcomes. Conclusions: Preexisting/treatment-induced humoral and antigen-specific cellular immunity did not impact tisagenlecleucel expansion, persistence, efficacy or safety. Clinical trial information: NCT02435849, NCT02228096, NCT02445248.
Graph Attention Network based Pruning for Reconstructing 3D Liver Vessel Morphology from Contrasted CT Images (2020)

With the injection of contrast material into blood vessels, multi-phase contrasted CT images can enhance the visibility of vessel networks in the human body. Reconstructing the 3D geometric morphology of liver vessels from the contrasted CT images can enable multiple liver preoperative surgical planning applications. Automatic reconstruction of liver vessel morphology remains a challenging problem due to the morphological complexity of liver vessels and the inconsistent vessel intensities among different multi-phase contrasted CT images. On the other side, high integrity is required for the 3D reconstruction to avoid decision making biases. In this paper, we propose a framework for liver vessel morphology reconstruction using both a fully convolutional neural network and a graph attention network. A fully convolutional neural network is first trained to produce the liver vessel centerline heatmap. An over-reconstructed liver vessel graph model is then traced based on the heatmap using an image processing based algorithm. We use a graph attention network to prune the false-positive branches by predicting the presence probability of each segmented branch in the initial reconstruction using the aggregated CNN features. We evaluated the proposed framework on an in-house dataset consisting of 418 multi-phase abdomen CT images with contrast. The proposed graph network pruning improves the overall reconstruction F1 score by 6.4% over the baseline. It also outperformed the other state-of-the-art curvilinear structure reconstruction algorithms.
Observing Single Enzyme Molecules Interconvert between Activity States upon Heating (2014)

In this paper, we demonstrate that single enzyme molecules of β-galactosidase interconvert between different activity states upon exposure to short pulses of heat. We show that these changes in activity are the result of different enzyme conformations. Hundreds of single β-galactosidase molecules are trapped in femtoliter reaction chambers and the individual enzymes are subjected to short heating pulses. When heating pulses are introduced into the system, the enzyme molecules switch between different activity states. Furthermore, we observe that the changes in activity are random and do not correlate with the enzyme's original activity. This study demonstrates that different stable conformations play an important role in the static heterogeneity reported previously, resulting in distinct long-lived activity states of enzyme molecules in a population.