gebhart/patrepeval huggingface dataset:
Synthesis and Separation of the Enantiomers of the Neuropeptide S Receptor Antagonist (9R/S)-3-Oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic Acid 4-Fluoro-benzylamide (SHA 68) (2011)

This study reports the synthesis, chromatographic separation, and pharmacological evaluation of the two enantiomers of the neuropeptide S receptor (NPSR) antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68). The (9R)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (compound 10) and (9S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (compound 10a) were synthesized and their purity assessed by chiral chromatography. The absolute configuration of the enantiomer 10 has been assigned from the crystal structure of the corresponding (S)-phenyl ethyl amine derivative 8. Calcium mobilization studies performed on cells expressing the recombinant NPSR demonstrated that compound 10 is the active enantiomer while the contribution of 10a to the NPSR antagonist properties of the racemic mixture is negligible.
OC11.06: Machine learning algorithms for classification of first trimester fetal brain ultrasound images (2021)

Imaging studies comprise an ideal groundwork for utilising machine learning. The purpose of our study was to evaluate the feasibility of machine learning tools for segmenting and classifying first trimester fetal brain ultrasound images. We used first trimester fetal brain images acquired by high-resolution transvaginal transducers. The study group included fetuses with a normal and an increased nuchal translucency. We processed them by two image segmentation methods: statistical region merging (SRM) and trainable weka segmentation (TWS), with training and testing sets in the latter. We have measured the fetal cerebral cortex in the original and processed images as an accuracy index for the segmentation process. We have used mean absolute percentage error (MAPE) to evaluate prediction accuracy. The SRM plugin revealed a total MAPE of 1.71% ± 1.62SD and a MAPE of 1.4% ± 1.32SD and 2.72% ± 2.21SD for the normal and increased NT groups, respectively. The TWS plugin displayed MAPE of 1.71% ± 0.59SD (testing set). There were no significant differences between the training and testing sets after 5-fold Cross-validation. Comparison of the images obtained from normal NT fetuses and increased NT fetuses revealed a MAPE of 1.52% ± 1.02SD and 2.63% ± 1.98SD (training and testing sets together). Our study demonstrates the feasibility of using ML algorithms to classify first trimester fetal ultrasound brain images. Our findings lay the foundation for further research of early diagnosis of fetal brain abnormalities, specifically in fetuses with an increased NT that comprise a high-risk population for neurodevelopmental sequela. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Validation of cord blood split products prepared by an automated method (2012)

We conclude that the preparation of the cord blood unit by the automated process results in a homogenous distribution of stem and progenitor cells. However, our findings show that the clonogenic capacity differs between the two segments.
Concepts of Switching in the Time-Triggered Network-on-Chip (2008)

This paper presents the concepts of switching in the Time-Triggered Network-on-Chip (TTNoC), which is the communication subsystem of the Time-Triggered System on-Chip (TTSoC) architecture. This includes the design of the switching components that make up the network-on-chip (NoC), as well as the switching algorithm applied in those components. Furthermore, we focus on the implications for the operation of the TTNoC entailed by these design choices, and deal with frequently used scenarios in a NoC, particularly multi-casting. Finally, we present results of a prototype implementation based on FPGA technology.
Effect of Polythiophene Content on Thermomechanical Properties of Electroconductive Composites (2021)

The thermal, mechanical and electrical properties of polymeric composites combined using polythiophene (PT) dopped by FeCl<sub>3</sub> and polyamide 6 (PA), in the aspect of conductive constructive elements for organic solar cells, depend on the molecular structure and morphology of materials as well as the method of preparing the species. This study was focused on disclosing the impact of the polythiophene content on properties of electrospun fibers. The elements for investigation were prepared using electrospinning applying two substrates. The study revealed the impact of the substrate on the conductive properties of composites. In this study composites exhibited good thermal stability, with T<sub>5</sub> values in the range of 230-268 °C that increased with increasing PT content. The prepared composites exhibited comparable PA T<sub>g</sub> values, which indicates their suitability for processing. Instrumental analysis of polymers and composites was carried out using Fourier Transform Infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), dynamic mechanical thermal analysis (DMTA) and scanning electron microscopy (SEM).
Interfacial study of clathrates confined in reversed silica pores (2021)

Storing methane in clathrates is one of the most promising alternatives for transporting natural gas (NG) as it offers similar gas densities to liquefied and compressed NG while offering lower safety risks. However, the practical use of clathrates is limited given the extremely low temperatures and high pressures necessary to form these structures. Therefore, it has been suggested to confine clathrates in nanoporous materials, as this can facilitate clathrate's formation conditions while preserving its CH<sub>4</sub> volumetric storage. Yet, the choice of nanoporous materials to be employed as the clathrate growing platform is still rather arbitrary. Herein, we tackle this challenge in a systematic way by computationally exploring the stability of clathrates confined in alkyl-grafted silica materials with different pore sizes, ligand densities and ligand types. Based on our findings, we are able to propose key design criteria for nanoporous materials favoring the stability of a neighbouring clathrate phase, namely large pore sizes, high ligand densities, and smooth pore walls. We hope that the atomistic insight provided in this work will guide and facilitate the development of new nanomaterials designed to promote the formation of clathrates.
Optically Induced Damping of the Surface Plasmon Resonance in Gold Colloids (1997)

The surface plasmon damping induced by high excitation of the electron gas is studied in femtosecond pump-and-probe experiments on gold colloids embedded in a sol-gel matrix. Optical excitation of single-particle interband transitions leads to a pronounced broadening of the surface plasmon line. A similar behavior is observed for resonant excitation of the surface plasmon. This broadening is the dominant optical nonlinearity of the system, and reflects the excitation-induced damping of the surface plasmon resonance. The time evolution of the damping rate follows that of the electronic scattering rate.
Supplementary Tables 1-14 from <i>SETD2</i> Is Recurrently Mutated in Whole-Exome Sequenced Canine Osteosarcoma (2023)

&lt;p&gt;File contains supplementary tables and figures for the main article. Supplementary Table 1 - Source for tools and databases used in the methods for analysis. Supplementary Table 2 - Summary of Somatic Point and Indel Mutation across the three breeds. Supplementary Table 3 - Summary of GISTIC-defined recurrent large-scale SCNAs and gene frequency. Supplementary Table 4 - List of GISTIC classified amplification genes. See attached excel spreadsheet. Supplementary Table 5 - List of GISTIC classified deletion genes. See attached excel spreadsheet. Supplementary Table 6 - List of GISTIC genes and their predicted roles in cancer. Supplementary Table 7 - Significantly over-represented pathways for GISTIC- and MuSiC-defined genes. Supplementary Table 8 - Significantly mutated genes as identified by MuSiC and the proportion of samples per breed that show mutation in them. Supplementary Table 9 - Putative driver genes as detected by MutSigCV algorithm Supplementary Table 10 - Putative driver genes assessed by VEP high-impact mutations and their variant allele frequency. Supplementary Table 11 - Mutations and their effects on p53 protein. Supplementary Table 12 - Mutations and their effects on SETD2 protein. Supplementary Table 13 - Count of non-silent mutations per breed/per germline for OSA susceptibility genes Supplementary Table 14 - Overlap of GISTIC-defined recurrent SCNA genes between humans and dogs. See attached excel spreadsheet.&lt;/p&gt;
Photoluminescence and cathodoluminescence analyses of GaN powder doped with Eu (2006)

A high yield process to produce gallium nitride (GaN) powder doped with europium (Eu) is presented. Eu is in situ incorporated into GaN powder through the reaction between a molten alloy of Ga and Eu along with NH3 at 1000 °C using Bi as a wetting agent. This procedure provides a method to produce a GaN:Eu phosphor with high yield and low cost. Room temperature photoluminescence (PL) measurements are studied on GaN:Eu powders with different Eu concentrations. The maximum PL intensity is obtained at a Eu concentration of 1.25 at. %. Cathodoluminescence spectra at room temperature exhibit many detailed transitions in the 530–630 nm range.
LMS to Deep Learning: How DSP Analysis Adds Depth to Learning (2019)

Difficulty in analyzing deep learning systems is preventing association of its parameters and state outputs with elements that are derived from theoretic considerations. Medical and criminal justice communities are excited by the possibilities nevertheless reluctant to adopt machine learning for fear of errors and bias. There is also concern among educators that mystifying learning may have long-term adverse pedagogical implications on human learning. Deep learning techniques have not received enthusiastic attention in the realm of communication systems, either. This is in part due the effectiveness of traditional analytical solutions that render classification error rates larger that 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> unacceptable. Understanding of deep networks for communications, and ability to perform comparison tests can be useful in developing scalable methods to understand them in more complex scenarios. This paper contributes a perspective and analysis with focus on Nyquist and non-Nyquist pulse shapes for bandlimited channels. It is hoped that this fundamental presentation motivates wider consideration of neural networks and deep learning for demodulation.
A fungal metabolite, novel isocyano epoxide. (1976)

The structure of a fungal metabolite isolated from Trichoderma sp. was determined.
(Invited) III-V-On-Insulator MOSFETs on Si Substrates Fabricated by Direct Bonding Technique (2010)

The heterogeneous integration of III-V semiconductors and Ge with Si wafers is expected to provide high performance logic CMOS under future technology nodes and other novel system-on-a -chip (SoC) applications. The III-V-On-Insulator (III-V-OI) structure fabricated by the wafer bonding technique is quite promising for realizing this heterogeneous integration for future LSIs. In this paper, we introduce our fabrication of InGaAs-OI structures with buried oxides (BOX) of ECR-SiO2 and ALD-Al2O3 by the direct wafer bonding and demonstrate the InGaAs-OI MOSFET operation on the Si substrates. The importance of the interface quality between InGaAs and BOX is addressed through the electron mobility behaviors. This technique is quite promising for the fabrication of novel CMOS device application under the 15 nm technology node and beyond.
Speech and multimodal interaction in mobile search (2011)

This tutorial highlights the characteristics of mobile search comparing with its desktop counterpart, reviews the state of art technologies of speech-based mobile search, and presents opportunities for exploiting multimodal interaction to optimize the efficiency of mobile search. It is suitable for students, researchers and practitioners working in the areas of spoken language processing, multimodal and search with an emphasis on a synergistic integration of these technologies for applications on mobile devices. We will provide detailed bibliography and sufficient literature for everyone interested to jumpstart work on this topic
Diminution of Supercooling of Electrolytes by Carbon Particles (1999)

We studied the supercooling behavior of a number of solutions of in ethylene carbonate‐ethyl methyl carbonate in 1:1 weight ratio with and without the presence of one of these carbons: activated carbon, carbon black, and mesocarbon microbeads. The results of our experiments of differential scanning calorimetry (DSC) show that the supercooling of less concentrated solutions is significantly diminished by the presence of a carbon, the degree and the nature of which depends on the concentration of the electrolyte and the type of carbon present. The results of our conductivity measurement also indicate precipitation in some of the electrolytes at low temperatures, which correlates well with the DSC results. We therefore conclude that the temperature range in which an electrolyte supercools without a nucleating material is unreliable for the operation of an electrochemical device containing such an electrolyte. Instead, the liquidus temperature of an electrolyte should be used as the lower limit of operation if the possibility of its crystallization is to be excluded. © 1999 The Electrochemical Society. All rights reserved.
Wittig Reactions on Photoprotoporphyrin IX:  New Synthetic Models for the Special Pair of the Photosynthetic Reaction Center (1999)

A first example of spirochlorin-chlorin dimer with fixed distances and orientations as potential model for the "special pair" of the photosynthetic reaction center is discussed. For the preparation of such a novel structure, the Wittig reagent of the desired "spacer" 5 was reacted with photoprotoporphyrin IX dimethyl ester 3 to produce the intermediate dimer 6, which on intramolecular [4 + 2] Diels-Alder cycloaddition gave an unexpected spirochlorin-chlorin dimer 9. Dehydration of dimer 6 under acid-catalyzed conditions generated the corresponding spirochlorin-porphyrin dimer 16 in quantitative yield. The asymmetry in dimer 6 caused by the biphenyl-type anisotropic effect was confirmed by NMR and model studies. The formation of dihydrobenzoporphyrin 14 by reacting chlorin 3 with the phosphonium salt of p-methylbenzylbromide 10 and isolation of 8-phenanthrenevinylporphyrin 19 from chlorin 7 further confirmed our proposed mechanism for the formation of a spirochlorin-chlorin dimer 9. Following a similar approach, chlorin 3 on reacting with bis-phosphonium salt of 4, 4'-bischloromethylbiphenyl produced conjugated chlorin dimer 25. The spectroscopic data obtained from these dimers suggest that, in these compounds, the individual chromophores are not behaving as an individual molecule, but as a single macrocycle. To examine whether the pi-pi interaction exhibited by dimer 9 resembles the structural arrangement of bacteriochlorophylls in reaction center (RC), we investigated the geometrical parameters used to characterize the pi-pi interactions in tetrapyrrolic macrocycles. Starting from the crystallographic coordinates of 9, the molecular mechanics energy minimization was performed to obtain the model dimer structure. The geometrical parameters that measure the single pyrrole ring overlap were used to compare the model structure with the crystallographic coordinates of the special pair in photosynthetic reaction center. The results indicated that the ring A of spirochlorin and the ring C of chlorin in our model dimer 9 mimic the ring A-ring A interaction found in the crystallographic special pairs, which are strategically placed by the surrounding photosynthetic reaction center protein matrix.
Glucagon-Like Peptide-1 Gene Therapy (2011)

Glucagon-like peptide 1 (GLP-1) is a small peptide component of the prohormone, proglucagon, that is produced in the gut. Exendin-4, a GLP-1 receptor agonist originally isolated from the saliva of H. suspectum or Gila monster, is a peptide that shares sequence and functional homology with GLP-1. Both peptides have been demonstrated to stimulate insulin secretion, inhibit glucagon secretion, promote satiety and slow gastric emptying. As such, GLP-1 and Exendin-4 have become attractive pharmaceutical targets as an adjunctive therapy for individuals with type II diabetes mellitus, with several products currently available clinically. Herein we summarize the cell biology leading to GLP-1 production and secretion from intestinal L-cells and the endocrine functions of this peptide and Exendin-4 in humans. Additionally, gene therapeutic applications of GLP-1 and Exendin-4 are discussed with a focus on recent work using the salivary gland as a gene therapy target organ for the treatment of diabetes mellitus.
Synthesis, Contact Printing, and Device Characterization of Ni-Catalyzed, Crystalline InAs Nanowires (2008)

InAs nanowires have been actively explored as the channel material for high performance transistors owing to their high electron mobility and ease of ohmic metal contact formation. The catalytic growth of non-epitaxial InAs nanowires, however, has often relied on the use of Au colloids which is non-CMOS compatible. Here, we demonstrate the successful synthesis of high yield of crystalline InAs nanowires with high yield and tunable diameters by using Ni nanoparticles as the catalyst material on amorphous SiO2 substrates. The nanowires show superb electrical properties with field-effect electron mobility ~2,700 cm2/Vs and ION/IOFF &gt;103. The uniformity and purity of the grown InAs nanowires are further demonstrated by large-scale assembly of parallel arrays of nanowires on substrates via the contact printing process that enables high performance, printable transistors, capable of delivering 5-10 mA ON currents (~400 nanowires).
Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing (2013)

Microphysiological systems provide a tool to simulate normal and pathological function of organs for prolonged periods. These systems must incorporate the key functions of the individual organs and enable interactions among the corresponding microphysiological units. The relative size of different microphysiological organs and their flow rates are scaled in proportion to in vivo values. We have developed a microphysiological three-dimensional engineered human skeletal muscle system connected to a circulatory system that consists of a tissue-engineered blood vessel as part of a high-pressure arterial system. The engineered human skeletal muscle tissue reproduces key mechanical behaviors of skeletal muscle in vivo. Pulsatile flow is produced using a novel computer-controlled magnetically activated ferrogel. The system is versatile and the muscle unit can be integrated with other organ systems. Periodic monitoring of biomechanical function provides a non-invasive assessment of the health of the tissue and a way to measure the response to drugs and toxins.
HIV‐1 Tropism and Survival in Vertically Infected Ugandan Infants (2008)

Complex patterns of HIV tropism were found in HIV-infected newborn infants. Subtype D infection was associated with X4 virus and with high-level replication in CCR5-bearing cells. High-level replication of R5 virus was associated with decreased infant survival.
An adaptive soft clipping method for spectrum sharing OFDMA systems (2009)

This paper proposes an adaptive soft clipping method for spectrum sharing OFDMA systems. The proposed method controls in-band and out-of-band distortion power by changing the nonlinearity parameter of soft clipping. The simulation results show that the proposed method can control the distortion power by 10 dB for a practical power amplifier. The results also show that a low-peak OFDMA transmitter can be realize with reasonable computational complexity because iterative processing for peak power reduction is unnecessary.
Supplementary Table S5 from A Clinical PET Imaging Tracer ([<sup>18</sup>F]DASA-23) to Monitor Pyruvate Kinase M2–Induced Glycolytic Reprogramming in Glioblastoma (2023)

&lt;p&gt;Hematology laboratory testing results of patients imaged with [18F]DASA-23&lt;/p&gt;
Self-Assembling, Chromogenic Receptors for the Recognition of Dicarboxylic Acids (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelf-Assembling, Chromogenic Receptors for the Recognition of Dicarboxylic AcidsM. Scott Goodman, Andrew D. Hamilton, and Jean WeissCite this: J. Am. Chem. Soc. 1995, 117, 32, 8447–8455Publication Date (Print):August 1, 1995Publication History Published online1 May 2002Published inissue 1 August 1995https://pubs.acs.org/doi/10.1021/ja00137a021https://doi.org/10.1021/ja00137a021research-articleACS PublicationsRequest reuse permissionsArticle Views1099Altmetric-Citations88LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development of an empirical large signal model for sic mesfets (2005)

We present the development of an empirical nonlinear model for silicon carbide MESFETs. The proposed channel current model is single piece, continuously differentiable and capable of accurately modeling the current-voltage characteristics of SiC MESFETs. The nonlinear model has been implemented in a commercial computer-aided-design (CAD) tool and its validity has been verified against DC I-V curves, S-parameters (up to 8 GHz) and load-pull power measurements.
Waveform design priorities in different wireless communications systems for 5G beyond (2017)

It is thought that a huge inclusive system will be achieved which includes many different wireless communications systems while 5G and beyond networks are being developed. These communications systems which can be classified according to different system requirements show a characteristic converging to a generic but flexible structure. In this study, waveform design priorities of various wireless communications systems are analyzed which include aeronautical communications, millimeter wave communications, cognitive radio, machine-to-machine communications, device-to-device communications, and vehicle-to-vehicle communications under the inclusive structures of 5G and beyond. Besides, some considerations are presented about the current waveform designs which allow flexible operations and have hybrid structures with adaptive properties for the inclusive structures of 5G beyond.