gebhart/patrepeval huggingface dataset:
Abstract 2907: Everolimus enhances the cytotoxic action of the immunotoxin, HA22, directed to CD22 on B-cell malignancies (2014)

Abstract Recombinant immunotoxins, antibody-toxin fusion proteins, are therapeutic proteins designed as targeted anti-cancer agents. Clinical trials of immunotoxins directed to surface CD22 or mesothelin are ongoing with a 50% complete response rate in patients with refractory Hairy Cell Leukemia as well as dramatic responses in some patients with advanced mesothelioma. To identify agents that could improve clinical efficacy further, a screen of 500 approved or near-approved compounds (MIPE-4) was conducted, revealing everolimus as a potential enhancer of Pseudomonas exotoxin-based recombinant immunotoxins. When the immunotoxin HA22 (moxetumomab pasudotox), which targets CD22, was added to various B-cell lines, everolimus enhanced cytotoxicity by 2-10-fold. Kinetic analyses indicated that combinations of HA22 and everolimus (0.25 uM) accelerated the cessation of protein synthesis in Nalm-6 and CA46 cells compared to either agent alone. Likewise, in CellTiterGlo assays of cell viability, combinations of HA22 and everolimus resulted in a greater loss of ATP from cells. Western blot analysis of key survival proteins indicated an early loss of Mcl-1 in combination treatments. Additional experiments are ongoing to extend these observations with the goal of uncovering insights in the mechanism of synergy seen with these two compounds. Citation Format: Antonella Antignani, Matteo Pasetto, Chris Choo, Evan Angelus, Lesley Mathews, Rajarshi Guha, Paul Shinn, Marc Ferrer, Craig J. Thomas, Ira Pastan, David J. Fitzgerald. Everolimus enhances the cytotoxic action of the immunotoxin, HA22, directed to CD22 on B-cell malignancies. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2907. doi:10.1158/1538-7445.AM2014-2907
Characterisation and Applications of Nematic Liquid Crystals in Microwave Devices (2011)

A method to characterise the dielectric properties of liquid crystal materials at microwave frequencies is presented that utilises a microstrip line with a layer of liquid crystal as a substrate. Accurate modelling of the liquid crystal and microwave fields is used to determine the dielectric properties of the liquid crystal from experimental measurements. The method is applied to a number of liquid crystal materials.
A microstrip patch-fed short backfire antenna for the tracking and data relay satellite system-continuation (TDRSS-C) multiple access (MA) array (2006)

A novel microstrip patch-fed short backfire antenna has been presented here for the first time as a candidate antenna element for the next generation TDRSS-C MA array. This design meets nearly all the specifications required for the enhanced MA array antenna element and promises to provide a lightweight low cost alternative over other designs presently being considered (i.e., corrugated horn, helix, waveguide-fed SBA). Simulations performed using IE3D and MWS agree with measured data, thus far, and indicate an 11% 15-dB bandwidth and a maximum directivity of 15.2 dBi. Future work involves further optimization of the radiation characteristics and the construction of the complete short backfire antenna structure to verify simulated results
Structure−Activity Relationships of 6-Methyl-benzo[b]thiophene-2-carboxylic Acid (1-{(S)-1-Benzyl-4-[4-(tetrahydropyran-4-ylmethyl)piperazin-1-yl]butylcarbamoyl}cyclopentyl)amide, Potent Antagonist of the Neurokinin-2 Receptor (2010)

As part of a project aimed at the identification of a series of small, orally available antagonists for the hNK2 receptor, starting from one of our capped dipeptide libraries, we succeeded in the chemical optimization of the first identified leads, finally producing a class of molecules with significant activity in our animal model after iv administration. We herein report the results of further chemical modifications made to reduce the overall peptide character of this series and the consequent improvement of their in vivo antagonist activity. The present work identified 6-methylbenzo[b]thiophene-2-carboxylic acid (1-{(S)-1-benzyl-4-[4-(tetrahydropyran-4-ylmethyl)piperazin-1-yl]butylcarbamoyl}cyclopentyl)amide (10i), endowed with subnanomolar potency in all the in vitro tests and being highly potent and of long duration upon in vivo testing after both iv and id dosing.
The Efficient Preparation of Radiolabeled Aromatic Amino Acids via Cu-Mediated Radiofluorination using Ni-complexes (2019)

The aim of this work was to develop a procedure for the preparation of F-18-labeled aromatic amino acids (AAA) via alcohol-enhanced Cu-mediated radiofluorination using Ni-BPX auxiliaries as easily-removable dual-protecting groups.
IBC’s International Conference on Novel Therapeutic Proteins for Oncology (Drug Discovery and Development) (1998)

It is estimated that 564,800 Americans will die of cancer in 1998. Even though earlier detection and healthier lifestyles may have led to some improvements in cancer mortality, new agents are urgently needed to treat incurable cancers. At the recent International Conference on Novel Therapeutic Proteins for Oncology, a wide range of new agents and strategies for targeting tumour cells were discussed. Many of these will be reviewed here.
Induced IL-10 Splice Altering Approach to Antiviral Drug Discovery (2014)

Ebola virus causes an acute hemorrhagic fever lethal in primates and rodents. The contribution of host immune factors to pathogenesis has yet to be determined and may reveal efficacious targets for potential treatment. In this study, we show that the interleukin (IL)-10 signaling pathway modulates Ebola pathogenesis. IL-10(-/-) mice and wild-type mice receiving antisense targeting IL-10 signaling via disrupting expression through aberrant splice altering were resistant to ebola virus infection. IL-10(-/-) mice exhibited reduced viral titers, pathology, and levels of IL-2, IL-6, keratinocyte-derived chemokine (KC), and macrophage inflammatory protein-1 α and increased interferon (IFN)-γ relative to infected wild-type mice. Furthermore, antibody depletion studies in IL-10(-/-) mice suggest a requirement for natural killer cells and IFN-γ for protection. Together, these data demonstrate that resistance to ebola infection is regulated by IL-10 and can be targeted in a prophylactic manner to protect against lethal hemorrhagic virus challenge.
On Inductive Abilities of Latent Factor Models for Relational Learning (2019)

&#x0D; &#x0D; &#x0D; Latent factor models are increasingly popular for modeling multi-relational knowledge graphs. By their vectorial nature, it is not only hard to interpret why this class of models works so well, but also to understand where they fail and how they might be improved. We conduct an experimental survey of state-of-the-art models, not towards a purely comparative end, but as a means to get insight about their inductive abilities. To assess the strengths and weaknesses of each model, we create simple tasks that exhibit first, atomic properties of binary relations, and then, common inter-relational inference through synthetic genealogies. Based on these experimental results, we propose new research directions to improve on existing models.&#x0D; &#x0D; &#x0D;
Detection and classification of objects from their radio shadows of GPS signals (2015)

The paper focuses on scientific issues related to new application of GPS in radar networks using the effect of Forward Scattering (FS) of electromagnetic waves to detect, locate and classify objects by their GPS radio shadows. The aim of the paper is to make experimental studies of GPS radio shadows of different objects irradiated by GPS signals and to develop methods and algorithms for automatic detection, estimation and classification of the shadows of these objects. The practical utility of the results obtained is to use a specific processing of the received signal in the GPS receiver, then to use the extracted information for positioning and classification of moving objects; for accurate assessment of the geographic location of fixed objects by method triangulation in systems for transport management, security of zones, subsequent identification of the detected objects from digital geographical maps.
ChemInform Abstract: Electrochemically Active Cross‐Linking Reaction for Fluorescent Labeling of Aliphatic Alkenes. (2012)

Abstract Electrochemical [3 + 2] cyclization of phenolic compounds with various alkenes provides access towards dihydrobenzofuran derivatives as fluorescent probes.
Linearized Robust Beamforming for Two-Way Relay Systems (2014)

In beamforming, channel state information (CSI) is used to design the beamforming vector (or matrix). Since in a practical system the CSI always needs to be estimated, channel estimation (CE) errors are inevitable, which could severely affect the performance of a beamforming scheme. In this paper, we present a novel beamforming method for two-way relay (TWR) systems that is robust against CE errors. The proposed method obtains a sub-optimal solution for the associated non-convex robust optimization problem by solving a set of closed-form linear equations. Simulations show a considerable performance gain over the rank-one relaxation-based semidefinite programming (SDP) solutions, especially for the cases where the relaxed problem becomes infeasible. In addition, there is significant reduction in complexity, making this method very attractive for practical implementation.
Chemotherapy in canine acute megakaryoblastic leukemia: a case report and review of the literature. (2010)

Acute myeloid leukemia (AML) in dogs is a rare disease with poor prognosis. In most subjects, palliative treatment or euthanasia is performed. A 3.5-year-old male castrated labrador with AML-M7, which was treated with induction polychemotherapy (8 cycles) using vincristine (0.5 mg/m(2)/cycle), daunorubicin (20 mg/m(2)/cycle), cytosine arabinoside (ARA-C, 100 mg/m(2)/cycle) and prednisolone (1 mg/kg/day) is reported. Treatment was well tolerated and complete remission was achieved. Postinduction chemotherapy consisted of ARA-C, daunorubicin and prednisolone. After 3, 5 and 18 months, the subject relapsed. Each relapse was treated with ARA-C (up to 1,000 mg/m(2)) and etoposide or daunorubicin. Again, no severe side-effects occurred and the disease was controlled, with 37 chemotherapy-cycles (ARA-C, 3 x 1,000 mg/m(2)/cycle), for 24 months. Based on a literature-search, this is the first report documenting a long-term response of canine AML, probably resulting from the high-dose ARA-C. Clinical trials using high-dose ARA-C are now required to confirm antileukemic efficacy in canine leukemias.
Novel blue-phosphorescent platinum(II) ternary complexes with β-diketonate and fluorinated phenylimidazole for organic light-emitting diodes (2022)

In this study, the one-pot synthesis of two novel Pt(II) β-diketonate compounds, namely Pt(tpim)(O^O) (1) and Pt(mtpim)(O^O) (2) (tpim = 1-([1,1′:3′,1′′-terphenyl]-2′-yl)-2-(4-fluorophenyl)-1 H-imidazole, mtpim = 2-(4-fluorophenyl)-1-(5′-methyl-[1,1′:3′,1′′-terphenyl]-2′-yl)-1 H-imidazole, and O^O = acetylacetonato), was achieved. Both compounds had a distorted square-planar geometry without direct intermolecular Pt(II)—Pt(II) interactions, which was attributed to the bulky terphenyl group of the C^N chelate as well as strong intermolecular Pt(II)—H(terphenyl/imidazole) interaction. Compounds 1 and 2 exhibited bright sky-blue-phosphorescent emission with a λ max = 490 nm and photoluminescence quantum yields of 0.50 and 0.47, respectively. The time-dependent density functional theory calculations revealed that the electronic transitions of both compounds were attributed to the combination of intraligand charge transfer (π (phenylimidazole) –π* (terphenyl) ) and ligand-to-ligand charge transfer (π (acac) –π* (terphenyl) ), in addition to a contribution from the metal-to-ligand charge transfer (Pt d –π* (terphenyl) ). Compounds 1 and 2, as the dopants, and 3′-di(9 H-carbazol-9-yl)-1,1′-biphenyl:9-(3'-carbazol-9-yl-5-cyano-biphenyl-3-yl)-9 H-carbazole-3-carbonitrile, as the mixed host were used to fabricate multilayer phosphorescent organic light-emitting diodes. Compound 1 doped in the emissive layer at a 10% doping level demonstrated a maximum current efficiency of 21.7 cd A −1 at 100 cd m −2 .
The Potency and Durability of DNA- and Protein-Based Vaccines Against Leishmania major Evaluated Using Low-Dose, Intradermal Challenge (2001)

DNA- and protein- based vaccines against cutaneous leishmaniasis due to Leishmania major were evaluated using a challenge model that more closely reproduces the pathology and immunity associated with sand fly-transmitted infection. C57BL/6 mice were vaccinated s.c. with a mixture of plasmid DNAs encoding the Leishmania Ags LACK, LmSTI1, and TSA (AgDNA), or with autoclaved L. major promastigotes (ALM) plus rIL-12, and the mice were challenged by inoculation of 100 metacyclic promastigotes in the ear dermis. When challenged at 2 wk postvaccination, mice receiving AgDNA or ALM/rIL-12 were completely protected against the development of dermal lesions, and both groups had a 100-fold reduction in peak dermal parasite loads compared with controls. When challenged at 12 wk, mice vaccinated with ALM/rIL-12 maintained partial protection against dermal lesions and their parasite loads were no longer significantly reduced, whereas the mice vaccinated with AgDNA remained completely protected and had a 1000-fold reduction in dermal parasite loads. Mice vaccinated with AgDNA also harbored few, if any, parasites in the skin during the chronic phase, and their ability to transmit L. major to vector sand flies was completely abrogated. The durable protection in mice vaccinated with AgDNA was associated with the recruitment of both CD8(+) and CD4(+) T cells to the site of intradermal challenge and with IFN-gamma production by CD8(+) T cells in lymph nodes draining the challenge site. These data suggest that under conditions of natural challenge, DNA vaccination has the capacity to confer complete protection against cutaneous leishmaniasis and to prevent the establishment of infection reservoirs.
2-Acetamido-N-benzyl-1,4-imino-1,2,4-trideoxy-L-ribitol (2005)

The relative configuration of the stereocentres in a potential hexosaminidase inhibitor, C 14 H 20 N 2 O 3 , prepared from d-lyxonolactone, has been established using X-ray crystallographic techniques.
FEWER T LYMPHOCYTES AND DECREASED PULMONARY INFLUENZA VIRUS BURDEN IN MICE EXPOSED TO 2,3,7,8-TETRACHLORODIBENZO-p-DIOXIN (TCDD) (2000)

The immune system is a sensitive target for the toxicity of the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In mice, immunotoxicity associated with exposure to TCDD includes suppression of humoral and cell-mediated immunity and impaired host resistance to infectious agents. However, the underlying mechanisms for these effects of TCDD are unknown. We previously reported that treatment of C57BI/6 mice with TCDD and influenza A virus increases mortality, impairs cytokine production, and suppresses T cell expansion and the generation of cytotoxic T lymphocytes (CTL) in the draining lymph node. However, the overall virus-specific cytolytic activity in the lung is unaffected. This enigmatic finding left several questions unanswered, including whether decreased CD8+ lymphocytes in the lung are the consequence of either delayed or suppressed recruitment of cells to the lung; whether exposure to TCDD affects the recruitment of CD4+ cells to the lung; and what effect TCDD treatment has on pulmonary virus burden. To compare the kinetics of the response in vehicle- and TCDD-treated mice, we examined the number of bronchoalveolar lavage (BAL) cells and CTL activity in the lung through d 10 postinfection. We found that the peak day for cellular influx and cytolytic activity in the lung is 9 d after infection. Immunophenotypic analysis of BAL cells shows that, when compared with BAL cells from infected controls, exposure to TCDD caused a 50% decrease in the percentage and number of both CD4+ and CD8+ cells. When the pulmonary virus burden was examined over time, we found that on d 1-5 postinfection, lungs from mice exposed to TCDD generally had lower virus titers than lung homogenates from vehicle-treated controls. By d 9 postinfection, no influenza virus was detected in lung homogenates from either vehicle- or TCDD-treated mice. These findings are likely not related to the observed decrease in CD4+ and CD8+ BAL cells; moreover, the diminished CD4+ population in the lung indicates that CD4+ cells are probably not compensating for the decreased CTL generation in TCDD-treated mice. Our observation that mice exposed to TCDD and infected with influenza virus do not have an increased pulmonary virus burden suggests either that TCDD treatment alters the host response to infection, creating a cellular environment that is less supportive for viral growth, or that exposure to TCDD directly affects influenza virus, leading to impaired virus replication within lung epithelial cells.
PLK1‐dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV‐infected mice (2021)

While Epstein-Barr virus (EBV) establishes a life-long latent infection in apparently healthy human immunocompetent hosts, immunodeficient individuals are at particular risk to develop lymphoproliferative B-cell malignancies caused by EBV. A key EBV protein is the transcription factor EBV nuclear antigen 2 (EBNA2), which initiates B-cell proliferation. Here, we combine biochemical, cellular, and in vivo experiments demonstrating that the mitotic polo-like kinase 1 (PLK1) binds to EBNA2, phosphorylates its transactivation domain, and thereby inhibits its biological activity. EBNA2 mutants that impair PLK1 binding or prevent EBNA2 phosphorylation are gain-of-function mutants. They exhibit enhanced transactivation capacities, accelerate the proliferation of infected B cells, and promote the development of monoclonal B-cell lymphomas in infected mice. Thus, PLK1 coordinates the activity of EBNA2 to attenuate the risk of tumor incidences in favor of the establishment of latency in the infected but healthy host.
Asynchronous Communication Fostering Social Interaction with CollaboraTV (2011)

With the advent of digital video recorders and video-on-demand services, the way in which we consume media is undergoing a fundamental change. People today are less likely to watch shows at the same time, let alone the same place. As a result, television viewing which was once a social activity has been reduced to a passive, isolated experience. CollaboraTV was designed to address this new mode of television viewing by directly supporting asynchronous communication. We demonstrated its ability to support this communal viewing experience through a lab study and a month-long field study. Our studies show that users understand and appreciate the utility of asynchronous interaction, are enthusiastic about CollaboraTV’s engaging social communication primitives and value implicit show recommendations from friends. Our results both provide a compelling demonstration of a social television system and raise new challenges for social television communication modalities.Request access from your librarian to read this chapter's full text.
A comparative metabolomic study on desi and kabuli chickpea (Cicer arietinum L.) genotypes under rainfed and irrigated field conditions (2020)

Chickpea is considered among the most important leguminous crops in the world. However, in recent years drought conditions and/or limited availability of water have significantly reduced the production of chickpea. The current study was aimed to understand the legume stress response at the metabolic level for the determination of chickpea genotypes which can resist yield losses and could be cultivated with limited water availability. Here, we have analyzed two genotypes of chickpea, desi and kabuli under rainfed condition using a GC-MS based untargeted metabolomics approach. Results revealed significant differences in several metabolite features including oxalic acid, threonic acid, inositol, maltose and L-proline between studied groups. Accumulation of plant osmoprotectants such as L-proline, sugars and sugar alcohols was higher in desi genotype than kabuli genotype of chickpea when grown under the rainfed condition. Metabolic pathway analysis suggests that the inositol phosphate metabolism was involved in plant defense mechanisms against the limited water availability.
Quantitative assessment of airway dimensions in young children with cystic fibrosis lung disease using chest computed tomography (2017)

AA-ratio differences were present in young CF patients relative to disease controls. A<sub>out</sub> A-ratio as an objective parameter for bronchiectasis could reduce sample sizes for clinical trials.
Supplementary Tables 1-5 from Development and Validation of a Gene Profile Predicting Benefit of Postmastectomy Radiotherapy in Patients with High-Risk Breast Cancer: A Study of Gene Expression in the DBCG82bc Cohort (2023)

&lt;p&gt;Supplementary Table 1: Distribution of clinico-pathological parameters among 112 patients included in the validation set. Supplementary Table 2: Assays and primers used for testing gene profile. Supplementary Table 3: Distribution of clinico-pathological parameters among 146 patients of the training set. Supplementary Table 4: Characteristics of patients included in and excluded from the technical transfer of the DBCG-RT profile to RT-qPCR and formalin fixed, paraffin embedded tissue (FFPE). Supplementary Table 5: Distribution of patients with "High LRR risk" and "Low LRR risk" within subgroups of clinical relevance for administration of PMRT.&lt;/p&gt;
Effect of Conditioning and Aging on the Bond Strength and Interfacial Morphology of Glass-ionomer Cement Bonded to Dentin. (2015)

Aging did not reduce the bond strength of the conventional glass-ionomer cement to dentin when the surface was pretreated with a polyalkenoic acid conditioner.
The effect of process and environmental changes on corrosion (1987)

Chemical and petrochemical plants producing the same chemicals, and using the same processes, often have different corrosion experiences. This can be the result of small changes in aeration, velocity of process streams, ambient or process temperatures, plant environment, the result of impurities in raw materials, or the effect of corrosion products. The quality and temperature of the available cooling water is particularly important. Guidelines are included to aid in identifying the factors that may be involved in a particular case.
Problemstellung und allgemeiner Lösungsweg (1980)

Die Auswertung der Literatur zeigt, daß zwei wesentliche Fragenkomplexe bisher noch unbeantwortet sind. Einmal geht es um konkrete Daten hinsichtlich des Einflusses der Phosphat-konzentration auf die relevanten Kriterien des Wascheffekts, die die Festlegung einer Minimalkonzentration erlauben würden, zum anderen liegt eine ausreichende Kenntnis über Zusammenhänge zwischen Buildereigenschaften und ihrer Beeinflussung der Waschwirkung noch nicht vor, die eine systematische Suche nach geeigneten Substituten erleichtern könnte.