gebhart/patrepeval huggingface dataset:
Simultaneous Photoacoustic Imaging and Cavitation Mapping in Shockwave Lithotripsy (2019)

Kidney stone disease is a major health problem worldwide. Shockwave lithotripsy (SWL), which uses high-energy shockwave pulses to break up kidney stones, is extensively used in clinic. However, despite its noninvasiveness, SWL can produce cavitation in vivo. The rapid expansion and violent collapse of cavitation bubbles in small blood vessels may result in renal vascular injury. To better understand the mechanism of tissue injury and improve treatment safety and efficiency, it is highly desirable to concurrently detect cavitation and vascular injury during SWL. Current imaging modalities used in SWL ( e.g. , C-arm fluoroscopy and B-mode ultrasound) are not sensitive to vascular injuries. By contrast, photoacoustic imaging is a non-invasive and non-radiative imaging modality that is sensitive to blood, by using hemoglobin as the endogenous contrast. Moreover, photoacoustic imaging is also compatible with passive cavitation detection by sharing the ultrasound detection system. Here, we have integrated shockwave treatment, photoacoustic imaging, and passive cavitation detection into a single system. Our experimental results on phantoms and in vivo small animals have collectively demonstrated that the integrated system is capable of capturing shockwave-induced cavitation and the resultant vascular injury simultaneously. We expect that the integrated system, when combined with our recently developed internal-light-illumination photoacoustic imaging, will find important applications for monitoring shockwave-induced vascular injury in deep tissues during SWL.
The effect of obesity on the mid-term survival and clinical outcome of cementless total hip replacement (2009)

The outcome of total hip replacement (THR) is potentially affected by the body mass index (BMI) of the patient. We studied the outcome of 2026 consecutive primary cementless THRs performed for osteoarthritis. The mean follow-up was 6.3 years (0 to 11.71) and no patient was lost to follow-up for survival analysis. The patients were divided into two groups according to their BMI as follows: non-obese (BMI < 30 kg/m(2)) and obese (BMI > or = 30 kg/m(2)). The obese patient undergoing surgery was found to be significantly younger (p < 0.001). The log-rank test for equality of survival showed no difference in the mid-term survival (p = 0.552) with an estimated survival at 11 years of 95.2% (95% CI 92.5 to 98.0) in the non-obese and 96.7% (95% CI 94.9 to 98.5) in the obese groups. The clinical and radiological outcome was determined in a case-matched study performed on 134 obese individuals closely matched with 134 non-obese controls. The non-obese group was found to have a significantly higher post-operative Harris hip score (p < 0.001) and an increased range of movement, but overall satisfaction with surgery was comparable with that of the obese patients. Radiological analysis of the acetabular and femoral components showed no significant differences with regard to radiolucent lines, osteolysis, ingrowth of the femoral component, the acetabular inclination angle or alignment of the femoral component. Our results suggest that the survival of cementless THR is not adversely affected by obesity. Obese patients can therefore be counselled that despite a lower clinical score, they should expect to be satisfied with the result of their THR with a mid-term survival rate equivalent to that of non-obese patients.
Fistulas of the Lower Urinary Tract: Percutaneous Approaches for the Management of a Difficult Clinical Entity (2004)

Fistulas of the lower urinary tract are uncommon conditions that may occur spontaneously or after therapy in patients with various pelvic abnormalities. When present, these fistulas are associated with urine leakage, which is often socially distressing and disabling. Unfortunately, factors that lead to the formation of genitourinary fistulas often increase their complexity or preclude surgical repair. A high failure rate is associated with surgical repair, and many patients are not optimal surgical candidates. For such patients, a percutaneous treatment approach is highly desirable. Percutaneous ureteral occlusion combined with insertion of a functioning nephrostomy tube allows complete diversion of urine in those patients in whom nephrostomy alone does not provide adequate relief. Many approaches to percutaneous ureteral occlusion have been used with variable success, including coils and gelatin sponge, isobutyl-2-cyanoacrylate, detachable balloons, radiofrequency electrocautery, ureteral clipping, and solid and soft polymer agents. Furthermore, percutaneous or retrograde ureteral stents may be used to preserve antegrade urine flow, and surgical options are also available. It is essential that the interventional radiologist involved in the care of these patients be familiar with these different techniques as well as with the limitations, pitfalls, and possible complications of their use.
Spontaneous Coronary Artery Dissection (2014)

PCI for SCAD is associated with high rates of technical failure even in those presenting with preserved vessel flow and does not protect against target vessel revascularization or recurrent SCAD. A strategy of conservative management with prolonged observation may be preferable.
Introduction (2007)

No AccessInjection Mold Design EngineeringAug 2007IntroductionDavid O. KazmerDavid O. Kazmerhttps://doi.org/10.3139/9783446434196.001SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2007Pages: 1-15Print ISBN: 978-3-446-41266-8eISBN: 978-3-446-43419-6 Copyright & Permissions© 2007 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
ChemInform Abstract: A Short Synthesis of Oxazolidinone Derivatives Linezolid and Eperezolid: A New Class of Antibacterials. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Controlled Release of Diphosphonates from Synthetic Polymers to Inhibit Calcification (1987)

Calcification is the most frequent cause of the failure of bioprosthetic heart valves fabricated from glutaraldehyde pretreated porcine aortic valves or bovine pericardium. Formulation and evaluation of controlled-release drug delivery system to inhibit bioprosthetic heart valve calcification is reviewed.
Charged-hadron production in pp, p+Pb, Pb+Pb, and Xe+Xe collisions at $$ \sqrt{s_{\textrm{NN}}} $$ = 5 TeV with the ATLAS detector at the LHC (2023)

A bstract This paper presents measurements of charged-hadron spectra obtained in pp , p +Pb, and Pb+Pb collisions at $$ \sqrt{s} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> </mml:math> or $$ \sqrt{s_{\textrm{NN}}} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:msub> <mml:mi>s</mml:mi> <mml:mi>NN</mml:mi> </mml:msub> </mml:msqrt> </mml:math> = 5 . 02 TeV, and in Xe+Xe collisions at $$ \sqrt{s_{\textrm{NN}}} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:msub> <mml:mi>s</mml:mi> <mml:mi>NN</mml:mi> </mml:msub> </mml:msqrt> </mml:math> = 5 . 44 TeV. The data recorded by the ATLAS detector at the LHC have total integrated luminosities of 25 pb − 1 , 28 nb − 1 , 0.50 nb − 1 , and 3 μ b − 1 , respectively. The nuclear modification factors R p Pb and R AA are obtained by comparing the spectra in heavy-ion and pp collisions in a wide range of charged-particle transverse momenta and pseudorapidity. The nuclear modification factor R p Pb shows a moderate enhancement above unity with a maximum at p T ≈ 3 GeV; the enhancement is stronger in the Pb-going direction. The nuclear modification factors in both Pb+Pb and Xe+Xe collisions feature a significant, centrality-dependent suppression. They show a similar distinct p T -dependence with a local maximum at p T ≈ 2 GeV and a local minimum at p T ≈ 7 GeV. This dependence is more distinguishable in more central collisions. No significant | η |-dependence is found. A comprehensive comparison with several theoretical predictions is also provided. They typically describe R AA better in central collisions and in the p T range from about 10 to 100 GeV.
Enabling Autonomic Meta-Scheduling in Grid Environments (2008)

Grid computing supports workload execution on computing resources that are shared across a set of collaborative organizations. At the core of workload management for grid computing is a software component, called meta-scheduler or grid resource broker, that provides a virtual layer on top of heterogeneous grid middleware, schedulers, and resources. Meta-schedulers typically enable end-users and applications to compete over distributed shared resources through the use of one or more instances of the same meta-scheduler, in a centralized or distributed manner, respectively. We propose an approach to enabling autonomic meta-scheduling through the use of a new communication protocol that -if adopted by different meta-schedulers or by the applications using them- can improve the workload execution while avoiding potential chaos, which can be resulted from blind competition over resources. This can be made possible by allowing the meta- schedulers and/or their applications to engage in a process to negotiate their roles (e.g., consumer, provider, or both), scheduling policies, service-level agreement, etc. To show the feasibility of our approach, we developed a prototype that enables some preliminary autonomic management among three different meta-schedulers, namely, GridWay, eNANOS, andTDWB.
EchoTag (2015)

We propose a novel mobile system, called EchoTag, that enables phones to tag and remember indoor locations without requiring any additional sensors or pre-installed infrastructure. The main idea behind EchoTag is to actively generate acoustic signatures by transmitting a sound signal with a phone's speakers and sensing its reflections with the phone's microphones. This active sensing provides finer-grained control of the collected signatures than the widely-used passive sensing. For example, because the sensing signal is controlled by EchoTag, it can be intentionally chosen to enrich the sensed signatures and remove noises from useless reflections. Extensive experiments show that EchoTag distinguishes 11 tags at 1cm resolution with 98% accuracy and maintains 90% accuracy even a week after its training. With this accurate location tagging, one can realize many interesting applications, such as automatically turning on the silent mode of a phone when it is placed at a pre-defined location/area near the bed or streaming favorite songs to speakers if it is placed near a home entertainment system. Most participants of our usability study agree on the usefulness of EchoTag's potential applications and the adequacy of its sensing accuracy for supporting these applications.
Simulation of visible/infrared sensor images (1996)

For developing an imaging system, a computer based imaging simulator that predicts the performance of the system is desired. The simulator synthesizes images by various sensors under a wide variety of field conditions in the early design stage. The advantages of eliminating unnecessary trial manufacturing and field testing under severe environmental conditions are given herewith. In the simulator described in this paper, spectral radiance of an object is assumed as being the sum of the reflection of solar irradiance and sky radiance and the emission obtained from the emissivity and temperature of an object. Wavelength bands are selected from the visible to the far-infrared wavelength region. Spatial resolution, noise, shading, ghosts, narcissus and mechanical vibration of the optical components are considered to be image degradations by the use of sensors. This paper describes the simulation procedure and illustrates synthesized images with several objects and scenarios such as wavelength band, atmospheric conditions and degradations by the use of sensors. These images show that the presented simulator is effective in determining the specifications of a desired system.
Synergistic interactions with PI3K inhibition that induce apoptosis (2017)

Activating mutations involving the PI3K pathway occur frequently in human cancers. However, PI3K inhibitors primarily induce cell cycle arrest, leaving a significant reservoir of tumor cells that may acquire or exhibit resistance. We searched for genes that are required for the survival of PI3K mutant cancer cells in the presence of PI3K inhibition by conducting a genome scale shRNA-based apoptosis screen in a <i>PIK3CA</i> mutant human breast cancer cell. We identified 5 genes (<i>PIM2, ZAK, TACC1, ZFR, ZNF565</i>) whose suppression induced cell death upon PI3K inhibition. We showed that small molecule inhibitors of the PIM2 and ZAK kinases synergize with PI3K inhibition. In addition, using a microscale implementable device to deliver either siRNAs or small molecule inhibitors in vivo, we showed that suppressing these 5 genes with PI3K inhibition induced tumor regression. These observations identify targets whose inhibition synergizes with PI3K inhibitors and nominate potential combination therapies involving PI3K inhibition.
Energy utilization in mourning doves. (1983)

http://deepblue.lib.umich.edu/bitstream/2027.42/53584/1/2020.pdf
Unsaturated heterocyclic systems. LXX. Stereochemistry of the thermal fragmentation of .beta.-lactams. Comparison with the pyrolysis of 1-azetines (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUnsaturated heterocyclic systems. LXX. Stereochemistry of the thermal fragmentation of .beta.-lactams. Comparison with the pyrolysis of 1-azetinesLeo A. Paquette, M. J. Wyvratt, and George R. Allen Jr.Cite this: J. Am. Chem. Soc. 1970, 92, 6, 1763–1765Publication Date (Print):March 1, 1970Publication History Published online1 May 2002Published inissue 1 March 1970https://pubs.acs.org/doi/10.1021/ja00709a060https://doi.org/10.1021/ja00709a060research-articleACS PublicationsRequest reuse permissionsArticle Views145Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Virtual Reality: Current Urologic Applications and Future Developments (2001)

The concept of virtual reality (VR) involves the computer generation of environments with which a user can interact directly. Virtual reality is now being used for medical applications, especially in the area of surgical simulation. As technology advances, VR simulation will play an important training role for both residents and urologists already in practice. This paper examines the history of VR, current developments, and its future implications for the field of urology.
Role of Protons on Activity and Selectivity of Fe-N-C Electroctatalysts for Oxygen Reduction Reaction (2019)

As one of the most promising candidates to replace Pt-based electrocatalysts for oxygen reduction reaction (ORR) in proton exchange membrane fuel cell (PEMFC), iron-nitrogen-carbon (Fe-N-C) materials have attracted tremendous research interests in recent years. Different from platinum-group-metal (PGM) catalysts, Fe-N-C have several categories of active sites: Fe-Nx has 4-electron pathway; pyrrolic-N and hydrogenated pyridinic-N can partially reduce oxygen into peroxide; pyridinic-N can reduce peroxide into water. Due to this complicated environment and numerous synthesis approaches from various precursors, the electrocatalysis mechanism of Fe-N-C still needs intensive investigation. Here we report the proton independence/dependence of rate-determining step (RDS) for a specific Fe-N-C catalyst via kinetic isotope effect (KIE), in addition to the activity inhibition of proton-involved N active sites via two molecular inhibitors. It is found that Fe-N-C can behave proton independent RDS like conventional Pt electrocatalyst in kinetic-controlled region, but it undergoes proton-coupled electron transfer in mass transport-controlled region, probably attributed to N active sites. It is also discovered that two molecules, tris(hydroxymethyl)aminomethane and etidronic acid, can inhibit and transform two categories of N active sites respectively: tris can effectively poison Fe-Nx active sites and pyridinic-N, resulting in obvious increase of peroxide yielding and drop of half-wave potential; etridonic acid can readily inhibit pyrrolic-N as well as hydrogenated pyridinic-N but no damage to Fe-Nx active sites, leading to decrease of peroxide yielding and no change of half-wave potentials. These results elucidate that Fe-N-C catalysts could, in principle, compete with Pt-based ORR catalysts through careful optimization of structure and morphology. Figure 1
Abstract 8955: Cardiopulmonary Phenotyping of Sex-Based Differences in a Feline Model of HFpEF (2021)

Introduction: Approximately 50% of all heart failure (HF) diagnoses can be classified as HF with preserved ejection fraction (HFpEF), which has no FDA approved therapies. HFpEF is more prevalent in females compared to males, but the underlying mechanisms for the development as a sex-based disorder are unknown. We previously described how slow progressive pressure overload (PO) in male felines recapitulates the HFpEF phenotype but have not investigated the female phenotype. Hypothesis: Females will develop a less severe HFpEF phenotype compared to males under the same pathological stress. Methods &amp; Results: Male (m) and female (f) domestic short felines (age 2mo) underwent aortic constriction (m: n=11; f: n=10) using a customized pre-shaped band or a sham procedure (m: n=7; f: n=7). Before surgery (baseline), there was no difference in body weight (BW) between groups and lung compliance was not different. Echocardiography revealed no significant difference in the ratio of left atrium to aortic root (LA/Ao), LA ejection fraction (LA EF), left ventricle (LV) ejection fraction, LV wall-thickness, and E/A ratio. By 4mo post-surgery, both males and females had developed cardiac dysfunction and decreased lung compliance. At this time, females had significantly smaller BWs than males. Despite the difference in BW, LV wall thickness and changes in E/A ratio were similar in both sexes in banded vs. shams. Importantly, LV EF did not change in any group. There was a decrease in LA EF and increased LA/Ao in all banded animals. Invasive hemodynamics at 4mo post-surgery showed no differences between sexes for the systolic pressure gradient generated by aortic banding. Banded males had higher LV end-diastolic pressure vs. banded females (m: 15.0±2.7mmHg; f: 8.1±1.9mmHg). However, there was a trend towards prolongation of tau and lower dp/dt min in banded females, suggestive of abnormal relaxation. There were no differences between banded males and females in heart weight/BW or cardiomyocyte cross-sectional area and both developed fibrosis. Conclusions: Exposure of male and female felines to PO resulted in similar cardiac hypertrophy, fibrosis, and decreased lung compliance. Females had lower LVEDP than males suggesting they may be protected from diastolic dysfunction.
Lullabies and Simplicity: A Cross-Cultural Perspective (1992)

Pairs of folk lullabies and comparison songs from different cultures were presented to adult listeners, who were required to choose the simpler song in each pair. Adults judged the lullaby excerpts as simpler whether presented with original field recordings, low-pass filtered versions that made the words unintelligible or excerpts synthesised with a uniform (piano) timbre. Structural analyses of the songs failed to reveal musical features that differentiated lullabies from other songs. Nevertheless, such analyses revealed melodic features that predicted adults' identification of lullabies.
A Two-Stage Real-Time Optimized EV Battery Cooling Control Based on Hierarchical and Iterative Dynamic Programming and MPC (2021)

The battery thermal management (BTM) system plays an increasingly important role today in the safety of electric vehicles (EVs) and hybrid electric vehicles (HEVs) as the battery capacity and power ratings keep growing. The BTM system is commonly coupled with the vehicle passenger cabin HVAC system. This integrated thermal system is a major onboard energy consumer, and its complexity brings challenges to its control. With the planned-ahead speed profile and the corresponding power trajectory obtained from the connected and automated vehicle (CAV) technology, predictive control makes a desirable option for the integrated system to maintain battery safety and passenger comfort while lowering energy consumption. However, in order to achieve both high accuracy and low cost in a wide control range, a very long prediction horizon and high sampling rate are both necessary. This will overwhelm the processing capacity of the onboard electronic control unit (ECU) if using conventional predictive control. In this paper, a two-stage predictive control strategy for the BTM and HVAC coupled system is proposed to solve this problem. In stage 1, based on the integrated cooling system efficiency features, a hierarchical and iterative dynamic programming (HIDP) scheme is designed to derive the optimal battery temperature trajectory to reach the set point at the end of the horizon with a modest computation burden. In stage 2, a control-oriented model is constructed for the cooling system and a model predictive controller (MPC) is accordingly built to track the trajectory from Stage 1 while enforcing the energy saving. A high set-point-tracking performance and as high as 10.61% energy saving for the cooling system in the UDDS cycle are verified by simulation results. The real-time implementation capability of the proposed strategy is demonstrated by the vehicle emulator experiments based on hardware in the loop (HIL) and a rapid control prototyping (RCP) platform.