gebhart/patrepeval huggingface dataset:
Beverages, Nonalcoholic (2000)

The article contains sections titled: 1. Introduction 1.1. Drinking Water 1.2. Fruit and Vegetable Juices and Derived Juice Products 1.3. Carbonated and Non-carbonated Beverages 2. Mineral Water 2.1. Definitions of Mineral Water 2.1.1. European 2.1.2. French 2.1.3. Codex Alimentarius 2.2. Development of Mineral Water 2.3. Legislation 2.4. Packaging of Mineral Water 2.5. Regulations for Labeling 2.6. Bottling 2.7. Conclusions 3. Fruit and Vegetable Juice Products 3.1. Temperate Fruits 3.1.1. Production 3.1.2. Harvesting and Transportation 3.1.3. General Fruit Quality 3.1.4. Apple Processing 3.1.5. Grape Processing 3.1.6. Nutritive and Chemical Composition 3.1.7. Regulations 3.2. Subtropical Fruits 3.2.1. Quality of Fruit for Processing 3.2.2. Processing 3.2.3. Processed Citrus Products 3.2.4. Chemical and Nutritive Data 3.3. Tropical Fruits 3.3.1. Introduction 3.3.2. Quality of Fruit for Processing 3.3.3. Processing 3.4. Vegetable Juices 4. Sweet Carbonated and Non-carbonated Beverages 4.1. Types of Beverages 4.1.1. Still Drinks 4.1.2. Carbonated Beverages 4.2. Flavoring Materials and Concentrates 4.2.1. Natural Flavoring Materials 4.2.2. Synthetic Flavoring Materials 4.2.3. Flavoring Concentrates 4.3. Beverage Production 4.3.1. Water Treatment 4.3.2. Syrup Preparation 4.3.3. Carbonation and Filling 4.3.4. Wastewater Treatment 4.3.5. Quality Control 5. Economic Aspects 5.1. Fruit Juices 5.2. Carbonated Soft Drinks 5.2.1. United States Market 5.2.2. International Markets
Clinical presentation, outcome, and prognostic markers in patients with intravascular large B‐cell lymphoma, a lymphoma study association (LYSA) retrospective study (2022)

Our study highlights the aggressive clinical picture of IVLBCL, in particular the frequency of macrophage activation syndrome, and the need for new therapies despite a response to R-CHOP-like regimen similar to non-intravascular diffuse large B-cell lymphomas.
Involvement of the plasmin system in dissociation of the insulin-like growth factor-binding protein complex. (1992)

A variety of treatments, including acid, heparin, and proteases, are known to free insulin-like growth factors (IGFs) from their binding proteins (IGFBPs). However, the physiologically relevant mechanism regulating the interaction of IGFs and IGFBPs is unknown. We report here the ability of plasmin to dissociate IGFs from IGFBPs. In chromatographic experiments, plasmin completely dissociated complexes of [125I] IGF-I-BP and [125I]IGF-II-BP formed with purified decidual IGFBP (hIGFBP-1) or IGFBPs present in medium conditioned by human osteosarcoma MG-63 cells. Plasmin dissociation of IGF-BP complexes was dose dependent. Neither plasminogen nor plasminogen activators (PAs) alone affected dissociation; however, activation of plasminogen to plasmin by either urokinase PA or tissue-type PA resulted in the dissociation of IGF-BP complexes. Plasmin dissociated immunoreactive and bioactive IGF from IGFBP equivalent to approximately 70% and approximately 60% of the acid control value, respectively. In medium conditioned by MG-63 cells, dissociation of IGF-BP complexes was catalyzed by PAs secreted by MG-63 cells, principally urokinase PA. Limited plasmin degradation of IGF was suggested by chromatographic experiments involving [125I] IGF. Treatment of uncomplexed IGF-I with plasmin concentrations equivalent to those in chromatographic experiments did not result in a significant loss of bioactivity, although a 2-fold increase in the plasmin concentration resulted in a approximately 20% loss of activity. Similar plasmin treatment of equimolar concentrations of hIGFBP-1 resulted in a marked degradation of IGFBP, with loss of IGF-binding ability. In vitro experiments confirmed plasmin dissociation of bioactive IGF-I from hIGFBP-1. In MG-63 cells, IGFBPs can form an IGF reservoir in the pericellular space surrounding the cells by combining IGFs with IGF-BP to form complexes that are incapable of binding to the IGF receptors. The secretion of PAs by osteosarcoma cells and the availability of plasminogen in the extravascular tissues indicate the possibility of a regulatory system in osteosarcoma cells in which pericellular plasmin affects the availability of IGFs to their membrane receptors.
Diabetes Gets on the Nerves of the Bone Marrow Niche (2014)

Diabetes is one of the major risk factors of coronary artery disease and chronic heart failure in the Western world (1). Currently, there are ∼28 million patients at age 20 years and older affected by diabetes in the U.S. alone with an annual incidence of 180,000 new cases. Moreover, 186,000 individuals, younger than 20 years of age, have diabetes, and each year ∼15,000 new patients are diagnosed with type 1 diabetes (1). The systemic nature of the metabolic derangement caused by diabetes inevitably results in comorbidities in several organs. Diabetes is the most common cause of neuropathy, which, in turn, represents its most frequent complication, affecting up to 50% of diabetic patients (2,3). A particularly severe form of diabetic neuropathy consists of the impairment of the sympathetic and parasympathetic divisions of the autonomic nervous system. Diabetic autonomic neuropathy (DAN) can affect the cardiovascular, genitourinary, and gastrointestinal organs. Cardiovascular autonomic neuropathy is an early and frequent complication of diabetes, comprising 7–15% of newly diagnosed individuals and 90% of chronically ill patients (4). In the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study, cardiovascular autonomic neuropathy has been shown to double the risk of death in diabetic patients (5).

In this issue, the findings discussed in the study by Albiero et al. (6) provide novel insights for the current understanding of the biology of DAN. The impact of DAN on the bone marrow (BM) and its niches is largely unknown. Stem cell niches are anatomical compartments constituted by cellular and extracellular components, which integrate local and systemic cues for the control of stem cell fate (7). The BM niche is a functional entity with a high degree of plasticity necessary for rapid adaptation to the needs of the organism. With aging and diseases, BM niches undergo extensive remodeling, …
Direct evidence for simultaneous CO and CO2 hydrogenation over Ru-RuOx/TiO2 catalyst (1994)

Reference LPI-ARTICLE-1994-033View record in Web of Science Record created on 2006-02-21, modified on 2017-05-12
Ad-hoc Document Retrieval using Weak-Supervision with BERT and GPT2 (2020)

We describe a weakly-supervised method for training deep learning models for the task of ad-hoc document retrieval. Our method is based on generative and discriminative models that are trained using weak-supervision based solely on the documents in the corpus. We present an end-to-end retrieval system that starts with traditional information retrieval methods, followed by two deep learning re-rankers. We evaluate our method on three different datasets: a COVID-19 related scientific literature dataset and two news datasets. We show that our method outperforms state-ofthe-art methods; this without the need for the expensive process of manually labeling data.
RB-Seeker: Auto-detection of Redirection Botnets. (2009)

A Redirection Botnet (RBnet) is a vast collection of compromised computers (called bots) used as a redirection/proxy infrastructure and under the control of a botmaster. We present the design, implementation and evaluation of a system called Redirection Botnet Seeker (RB-Seeker) for automatic detection of RBnets by utilizing three cooperating subsystems. Two of the subsystems are used to generate a database of domains participating in redirection: one detects redirection bots by following links embedded in spam emails, and the other detects redirection behavior based on network traces at a large university edge router using sequential hypothesis testing. The database of redirection domains generated by these two subsystems is fed into the final subsystem, which then performs DNS query probing on the domains over time. Based on certain behavioral attributes extracted from the DNS queries, the final subsystem makes use of a 2-tier detection strategy utilizing hyperplane decision functions. This allows it to quickly identify aggressive RBnets with a low false-positive rate (&amp;lt; 0.008%), while also accurately detecting stealthy RBnets (i.e., those mimicking valid DNS behavior, such as CDNs) by monitoring their behavior over time. Using DNS behavior as a means of detecting RBnets, RB-Seeker is impervious to the botmaster’s choice of Command-and-Control (C&amp;amp;C) channel (i.e., how the botmaster communicates and controls the bots) or use of encryption. 1
Characterization and purification of a functional rat glucocorticoid receptor overexpressed in a baculovirus system (1991)

The structure-function relationship of the oligomeric unactivated glucocorticoid receptor is not fully understood. An essential step in the process of understanding such a relationship involves the production of large quantities of the receptor. Using a baculovirus expression system we have been able to overproduce a recombinant rat glucocorticoid receptor (rGR). A cDNA coding for the entire rGR was introduced into the genome of the wild type baculovirus, Autographa californica nuclear polyhedrosis virus, by an in vivo recombination event. Based on specific steroid binding, insect cells infected with the recombinant baculovirus expressed 1-3 x 10(6) receptor molecules/cell which is 15-45 times more than that expressed normally in a hepatocyte. The recombinant rGR expressed in insect cells is indistinguishable from the bona fide rGR with respect to immunogenic reactivity, cytoplasmic localization, sedimentation, chromatographic and electrophoretic mobility, and hormone and DNA binding. Furthermore, the recombinant rGR is expressed as a functional protein as demonstrated by its ability to specifically bind a glucocorticoid agonist, to translocate from the cytoplasm to the nucleus upon hormone-binding, and to act as a transcriptional enhancer. Pulse labeling of recombinant baculovirus-infected insect cells with 32Pi and isolation of the labeled products by immunoprecipitation demonstrated that the recombinant rGR is a phosphoprotein. Thus, the recombinant rGR expressed in insect cells is biologically active and is suitable for structural and functional analysis. A simple three-step purification procedure of the unactivated recombinant rGR is described.
DMD-Unmanaged Long-Haul SDM Transmission Over 2500-km 12-core × 3-mode MC-FMF and 6300-km 3-mode FMF Employing Intermodal Interference Cancelling Technique (2018)

We demonstrate DMD-unmanaged 2500-km 12-core × 3-mode MC-FMF and 6300-km 3-mode FMF transmission. DMD-induced pulse broadening and MDL accumulation were significantly suppressed by transmission with cyclic mode permutation. Interference cancellation mitigated MDL-impact with > 2-dB Q-factor improvement.
Data-driven selective sampling for marine vehicles using multi-scale paths (2017)

This paper addresses adaptive coverage of a spatial field without prior knowledge. Our application in this paper is to cover a region of the sea surface using a robotic boat, although the algorithmic approach has wider applicability. We propose an anytime planning technique for efficient data gathering using point-sampling based on non-uniform data-driven coverage. Our goal is to sense a particular region of interest in the environment and be able to reconstruct the measured spatial field. Since there are autonomous agents involved, there is a need to consider the costs involved in terms of energy consumed and time required to finish the task. An ideal map of the scalar field requires complete coverage of the region, but can be approximated by a good sparse coverage strategy along with an efficient interpolation technique. We propose to optimize the trade off between the environmental field mapping and the costs (energy consumed, time spent, and distance traveled) associated with sensing. We present an anytime algorithm for sampling the environment adaptively by following a multi-scale path to produce a variable resolution map of the spatial field. We compare our approach to a traditional exhaustive survey approach and show that we are able to effectively represent a spatial field spending minimum energy. We present results that indicate our sampling technique gathering most informative samples with least travel. We validate our approach through simulations and test the system on real robots in the open ocean.
Data from Proteomic Characterization of the Angiogenesis Inhibitor SU6668 Reveals Multiple Impacts on Cellular Kinase Signaling (2023)

&lt;div&gt;Abstract&lt;p&gt;Knowledge about molecular drug action is critical for the development of protein kinase inhibitors for cancer therapy. Here, we establish a chemical proteomic approach to profile the anticancer drug SU6668, which was originally designed as a selective inhibitor of receptor tyrosine kinases involved in tumor vascularization. By employing immobilized SU6668 for the affinity capture of cellular drug targets in combination with mass spectrometry, we identified previously unknown targets of SU6668 including Aurora kinases and TANK-binding kinase 1. Importantly, a cell cycle block induced by SU6668 could be attributed to inhibition of Aurora kinase activity. Moreover, SU6668 potently suppressed antiviral and inflammatory responses by interfering with TANK-binding kinase 1–mediated signal transmission. These results show the potential of chemical proteomics to provide rationales for the development of potent kinase inhibitors, which combine rather unexpected biological modes of action by simultaneously targeting defined sets of both serine/threonine and tyrosine kinases involved in cancer progression.&lt;/p&gt;&lt;/div&gt;
A Direct Approach to α-Trifluoromethylamines (2003)

[reaction: see text] S-[1-(N-Acetylamino)-2,2,2-trifluoroethyl]-O-ethyl dithiocarbonate (6), a readily available xanthate, adds efficiently to various functionalized olefins to give the corresponding adducts 8 via a radical chain reaction initiated by a small amount of lauroyl peroxide.
ZnT8-Specific CD4+ T Cells Display Distinct Cytokine Expression Profiles between Type 1 Diabetes Patients and Healthy Adults (2013)

Determination of antigen-specific T cell repertoires in human blood has been a challenge. Here, we show a novel integrated approach that permits determination of multiple parameters of antigen-specific T cell repertoires. The approach consists of two assays: the Direct assay and the Cytokine-driven assay. Briefly, human PBMCs are first stimulated with overlapping peptides encoding a given antigen for 48 hours to measure cytokine secretion (Direct assay). Peptide-reactive T cells are further expanded by IL-2 for 5 days; and after overnight starvation, expanded cells are stimulated with the same peptides from the initial culture to analyze cytokine secretion (Cytokine-driven assay). We first applied this integrated approach to determine the type of islet-antigen-specific T cells in healthy adults. Out of ten donors, the Direct assay identified GAD65-specific CD4(+) T cells in three adults and zinc transporter 8 (ZnT8)-specific CD4(+) T cells in five adults. The intracytoplasmic cytokine staining assay showed that these islet-antigen-specific CD4(+) T cells belonged to the CD45RO(+) memory compartment. The Cytokine-driven assay further revealed that islet-antigen-specific CD4(+) T cells in healthy adults were capable of secreting various types of cytokines including type 1 and type 2 cytokines as well as IL-10. We next applied our integrated assay to determine whether the type of ZnT8-specific CD4(+) T cells is different between Type 1 diabetes patients and age/gender/HLA-matched healthy adults. We found that ZnT8-specific CD4(+) T cells were skewed towards Th1 cells in T1D patients, while Th2 and IL-10-producing cells were prevalent in healthy adults. In conclusion, the Direct assay and the Cytokine-driven assay complement each other, and the combination of the two assays provides information of antigen-specific T cell repertoires on the breadth, type, and avidity. This strategy is applicable to determine the differences in the quality of antigen-specific T cells between health and disease.
Process Optimization of CoSi2 Formation on P-Doped Poly-Si by Hot Wall-Based Rapid Thermal Annealing (2015)

To achieve low resistivity contacts, the effect of annealing temperature and time on the resulting resistivity of CoSi 2 contacts with P-doped poly-Si was investigated using a single wafer furnace-based (hot wall) rapid thermal annealing (RTA) system. The hot wall RTA resulted in significantly (&gt;20%) lower sheet resistance (Rs) from the equivalent RTA process using conventional tungsten halogen lamp-based (cold wall) RTA systems over a very wide process window. Dopant (P) depth profiling results by secondary ion mass spectroscopy (SIMS) revealed that the P atoms in the CoSi 2 film and at the CoSi 2 /P-doped poly-Si interface, redistribute very differently under different RTA conditions. The CoSi 2 formation process was optimized utilizing characteristics of P pile-up near the CoSi 2 /P-doped poly-Si interface to suppress P depletion from the P-doped poly-Si layer.
Introduction to XPS Characterization of the Materials in Novel Carbon Nanotube-Based, Microfabricated, Thin Layer Chromatography Plates (2013)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Nitesh Madaan, Matthew R. Linford; Introduction to XPS Characterization of the Materials in Novel Carbon Nanotube-Based, Microfabricated, Thin Layer Chromatography Plates. Surf. Sci. Spectra 1 December 2013; 20 (1): 35. https://doi.org/10.1116/11.20130699 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAVS: Science & Technology of Materials Interfaces and ProcessingSurface Science Spectra Search Advanced Search |Citation Search
Analysis of multimode interferometers (2016)

A general analytical formula describing the transfer function between the input and output of an arbitrary rectangular multimode interference (MMI) coupler has been derived using the elliptic theta function ϑ(x', z'). This formula provides the positions, amplitudes and relative phases of all the self-images of a given source. It is shown how the transfer function can be used as a propagation matrix for any rectangular NxM MMI. Specific simplified solutions for NxN, symmetric and paired MMIs are also derived from the general formula.
Comparison of Pneumatic Retinopexy and Scleral Buckle for Primary Rhegmatogenous Retinal Detachment Repair (2017)

This study demonstrates that SBP has a significantly higher rate of single surgery reattachment than PR, along with improved final VA. Initial success of PR may be an important predictor of final visual outcome. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:887-893.].
Diagnosis and management of mastocytosis: an emerging challenge in applied hematology (2015)

Mastocytosis is a unique and rare neoplasm defined by abnormal expansion and accumulation of clonal mast cells (MCs) in one or multiple organ systems. Most adult patients are diagnosed to have systemic mastocytosis (SM). Based on histological findings and disease-related organ damage, SM is classified into indolent SM (ISM), smoldering SM (SSM), SM with an associated hematologic non-MC-lineage disease (SM-AHNMD), aggressive SM (ASM), and MC leukemia (MCL). The clinical picture, course, and prognosis vary profoundly among these patients. Nonetheless, independent of the category of SM, neoplastic cells usually exhibit the KIT point-mutation D816V. However, in advanced SM, additional molecular defects are often detected and are considered to contribute to disease progression and drug resistance. These lesions include, among others, somatic mutations in TET2, SRSF2, ASXL1, CBL, RUNX1, and RAS. In SM-AHNMD, such mutations are often found in the "AHNMD component" of the disease. Clinical symptoms in mastocytosis result from (1) the release of proinflammatory and vasoactive mediators from MCs, and (2) SM-induced organ damage. Therapy of SM has to be adjusted to the individual patient and the SM category: in those with ISM and SSM, the goal is to control mediator secretion and/or mediator effects, to keep concomitant allergies under control, and to counteract osteoporosis, whereas in advanced SM (ASM, MCL, and SM-AHNMD) anti-neoplastic drugs are prescribed to suppress MC expansion and/or to keep AHNMD cells under control. Novel drugs directed against mutated KIT and/or other oncogenic kinase targets are tested currently in these patients. In rapidly progressing and drug-resistant cases, high-dose polychemotherapy and stem cell transplantation have to be considered.
Giant nonlinear conductivity in an organic conductor with a sharp metal-insulator transition:β″−(BEDT-TTF)3(HSO4)2 (2009)

The title organic conductor, where BEDT-TTF is bis(ethylenedithio)tetrathia-fulvalene, undergoes a sharp metal-insulator transition at ${T}_{\text{MI}}=126\text{ }\text{K}$, below which giant nonlinear conductivity accompanied by negative differential resistance (NDR) is observed. In the usual organic conductors, resistance in the high-current region decreases following the power of current, but the present system shows abrupt NDR. The extraordinary NDR is quantitatively explained by phenomenology based on the energy balance and attributed to the sharp phase transition at ${T}_{\text{MI}}$. This type of nonlinear transport is called ``transition'' type in contrast to the conventional ``activation'' type. The transition type is also characterized by the negative temperature dependence of the threshold power. It is predicted that there is a possibility that oscillating voltage emerges, but chaotic output never appears in this type. The different shapes of the two-probe current-voltage characteristics and pulse responses are also interpreted in view of the small ratio of the low-conducting and high-conducting states.
Non‐IBD immunological diseases are a risk factor for reduced survival in PSC (2012)

Patients with concomitant IDs, especially IMID, are a clinically important subgroup of PSC patients. This significant phenotype warrants further genetic and immunological studies.
Synergistic computational and experimental studies of a phosphoglycosyl transferase membrane/ligand ensemble (2023)

ABSTRACT Complex glycans serve important functions in all living systems. Many of these intricate and byzantine biomolecules are assembled employing biosynthetic pathways wherein the constituent enzymes are membrane associated. A signature feature of the stepwise assembly processes is the essentiality of unusual linear long-chain polyprenol phosphate-linked substrates, such as un-decaprenol phosphate in bacteria. In this study we focus on a small enzyme, PglC from Campylobacter , structurally characterized for the first time in 2018, as a detergent solubilized construct. PglC is a monotopic phosphoglycosyl transferase (PGT), that embodies the functional core structure of the entire enzyme superfamily and catalyzes the first membrane-committed step in a glycoprotein assembly pathway. The size of the enzyme is significant as it enables high level computation and relatively facile, for a membrane protein, experimental analysis. Our ensemble computational and experimental results reveal a specific interaction of undecaprenol phosphate with PGT cationic residues and suggest a role for critical conformational transitions and electrostatic steering in substrate recognition, overcoming significant energetic barriers to binding. The study highlights that computation, guided by fundamental chemical principles, can advance the study of biochemical processes at membrane bilayers and provide chemical insight at a molecular level that cannot be derived by experiment alone. Insert Table of Contents artwork here