gebhart/patrepeval huggingface dataset:
The skin in disseminated intravascular coagulation. (1973)

Journal Article The skin in disseminated intravascular coagulation: PROSPECTIVE ANALYSIS OF THIRTY‐SIX CASES Get access STANLEY J. ROBBOY, STANLEY J. ROBBOY Departments of Pathology, Dermatology and Medicine, Harvard Medical School, and Massachusetts General Hospital, Boston, Department of Pathology, U.S. Ireland Army Hospital, Fort Knox, Kentucky, and the Laboratory of Biochemical Genetics, NHLI, NIH, Bethesda, MD., U.S.A Requests for reprints: Dr Robboy, Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114 U.S.A. Search for other works by this author on: Oxford Academic Google Scholar MARTIN C. MIHM, MARTIN C. MIHM Departments of Pathology, Dermatology and Medicine, Harvard Medical School, and Massachusetts General Hospital, Boston, Department of Pathology, U.S. Ireland Army Hospital, Fort Knox, Kentucky, and the Laboratory of Biochemical Genetics, NHLI, NIH, Bethesda, MD., U.S.A Search for other works by this author on: Oxford Academic Google Scholar ROBERT W. COLMAN, ROBERT W. COLMAN Departments of Pathology, Dermatology and Medicine, Harvard Medical School, and Massachusetts General Hospital, Boston, Department of Pathology, U.S. Ireland Army Hospital, Fort Knox, Kentucky, and the Laboratory of Biochemical Genetics, NHLI, NIH, Bethesda, MD., U.S.A Search for other works by this author on: Oxford Academic Google Scholar JOHN D. MINNA JOHN D. MINNA Departments of Pathology, Dermatology and Medicine, Harvard Medical School, and Massachusetts General Hospital, Boston, Department of Pathology, U.S. Ireland Army Hospital, Fort Knox, Kentucky, and the Laboratory of Biochemical Genetics, NHLI, NIH, Bethesda, MD., U.S.A Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 88, Issue 3, 1 March 1973, Pages 221–229, https://doi.org/10.1111/j.1365-2133.1973.tb07538.x Published: 01 March 1973 Article history Accepted: 29 August 1972 Published: 01 March 1973
Performance of earth pressure cell as grain pressure transducer in a model silo (2007)

Numerous methods have been proposed for determining the pressure exerted by grain at discrete locations in a storage structure, but few satisfactory solutions have been found. Earth pressure cells were tested as potential measurement devices for grain bins. Earth pressure cells are commercial transducers designed for geotechnical applications. Calibration of the earth pressure cell was performed in a pressurized chamber filled with wheat under normal load as well as shear load. The cell was tested in a model grain silo 1.83 m in diameterd with a height h c of 5.75 m. Vertical floor pressures and horizontal wall pressures were measured at different points in the model bin. The vertical floor pressure pvi was measured at two different radial locations and horizontal wall pressure p h was measured at four different wall heights. The vertical floor pressure obtained using the earth pressure cell was in good agreement with the mean floor pressure Pv calculated using load cells that supported the entire floor or the bin. Considerable variation in the vertical floor pressure along the silo floor radius was observed. The variation of the lateral-to-vertical pressure ratio, K, was monitored during each fill-unload cycle of the model silo. In the case of the maximum h/d ratio of 2, K increased during filling and stabilized after reaching a grain h/d ratio of 1.3. At the onset of discharge, the pressure ratio immediately increased up to value of approximately 0.7, and remained stable during unloading down to a h/d ratio of approximately 0.65 when K decreased rapidly.
Ablation of a Ca2+‐activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation (2009)

Small conductance Ca(2+)-activated K(+) channels (SK channels) have been reported in excitable cells, where they aid in integrating changes in intracellular Ca(2+) (Ca(2+)(i)) with membrane potential. We have recently reported the functional existence of SK2 channels in human and mouse cardiac myocytes. Moreover, we have found that the channel is predominantly expressed in atria compared to the ventricular myocytes. We hypothesize that knockout of SK2 channels may be sufficient to disrupt the intricate balance of the inward and outward currents during repolarization in atrial myocytes. We further predict that knockout of SK2 channels may predispose the atria to tachy-arrhythmias due to the fact that the late phase of the cardiac action potential is highly susceptible to aberrant excitation. We take advantage of a mouse model with genetic knockout of the SK2 channel gene. In vivo and in vitro electrophysiological studies were performed to probe the functional roles of SK2 channels in the heart. Whole-cell patch-clamp techniques show a significant prolongation of the action potential duration prominently in late cardiac repolarization in atrial myocytes from the heterozygous and homozygous null mutant animals. Moreover, in vivo electrophysiological recordings show inducible atrial fibrillation in the null mutant mice but not wild-type animals. No ventricular arrhythmias are detected in the null mutant mice or wild-type animals. In summary, our data support the important functional roles of SK2 channels in cardiac repolarization in atrial myocytes. Genetic knockout of the SK2 channels results in the delay in cardiac repolarization and atrial arrhythmias.
Antisense MDM2 oligonucleotides restore the apoptotic response of prostate cancer cells to androgen deprivation (2004)

Our results suggest that the apoptotic response of prostate cancer to AD is strongly influenced by MDM2 expression. Antisense MDM2 has broad potential as a therapeutic agent to sensitize prostate cancer cells to AD therapy by enhancing apoptotic cell death.
Protocol for the purification of protected carbohydrates: toward coupling automated synthesis to alternate-pump recycling high-performance liquid chromatography (2016)

Given recent advances in automated oligosaccharide synthesis, analytical techniques that can be coupled to a synthetic framework are needed to not just identify but also purify to homogeneity protected carbohydrate compounds at levels of ≥99.5% purity. Herein, an alternate-pump recycling high-performance liquid chromatography (R-HPLC) method has been developed to allow purification of protected carbohydrates at levels of ≥99.5% purity.
Flow Cytometric Determination of Ploidy in Prostatic Adenocarcinoma: A Comparison with Seminal Vesicle Involvement and Histopáthglogicál Grading as a Predictor of Clinical Recurrence (1988)

Flow cytometry was used to evaluate 88 deparaffinized radical prostatectomy specimens to compare deoxyribonucleic acid ploidy in prostatic adenocarcinoma as a predictor of disease progression with other well documented predictors of clinical recurrence. Aneuploidy, Gleason grade and seminal vesicle involvement were nonindependent variables, and all correlated to statistical significance with disease recurrence. The incidence of aneuploidy in the total population was 51 of 88 (58 per cent). Aneuploidy was found in 25 of 28 primary tumors (89 per cent) from patients who subsequently had recurrent disease. Aneuploidy was noted in 40 of 59 specimens (68 per cent) exhibiting seminal vesicle involvement, compared to 11 of 29 (38 per cent) without seminal vesicle involvement (p less than 0.01). The probability of an interval free of disease of 60 months was calculated by Kaplan-Meier analysis to be 85 per cent in diploid specimens compared to 9 per cent in aneuploid specimens (p less than 0.001), and 87 per cent in the absence of seminal vesicle involvement compared to 28 per cent in the presence of seminal vesicle involvement (p less than 0.003). The probability of remaining free of disease in patients exhibiting concomitant diploidy and seminal vesicle involvement (17) was 73 per cent compared to 8 per cent in those with aneuploid specimens and seminal vesicle involvement (p less than 0.004). The incidence of recurrence in patients with Gleason sums of 7 or less was 22 per cent compared to 62 per cent in patients with Gleason sums of greater than 7. There was a 29 per cent incidence of recurrence in intermediate grade tumors (Gleason sum 5 to 7) but only 5 per cent of the patients with intermediate grade diploid tumors had recurrent disease. In conclusion, the recognition of a deoxyribonucleic acid aneuploid stem line in a primary prostatic adenocarcinoma is correlated statistically with a greater likelihood of seminal vesicle invasion and subsequent development of recurrent disease. The markedly increased probability of remaining free of disease in diploid patients, even in the presence of seminal vesicle involvement, suggests that routine flow cytometric analysis in prostatic adenocarcinoma would significantly enhance prognostic stratification.
Quality of diet and food choices of Finnish young men: a sociodemographic and health behaviour approach (2010)

These results indicate that in early adulthood, eating habits cluster with other health behaviours among men. In this age group, education is associated with core food but not with extra food eating habits. Furthermore, seasonal variation is seen in both types of eating. When promoting healthy eating, a distinction between core foods and extra foods by using feasible indexes will be helpful in targeting the efforts.
Web to world: predicting transitions from self-diagnosis to the pursuit of local medical assistance in web search. (2010)

Many people turn to the Web for self-diagnosis and healthcare assessment based on limited knowledge of signs, symptoms, and disorders. Studies of search and browsing for healthcare information have shown that reviewing Web content can lead to escalations from concerns about common, typically benign symptoms to searches on rare and frightening disorders. We explore the potential for the Web to induce costly and potentially unnecessary engagements with health professionals. We present findings on the transition of search on common symptoms to the pursuit of in-world healthcare resources such as nearby physicians and healthcare facilities. We build models that predict the transition from searches on initial common symptoms to queries pursuing local medical expertise, using evidence about a user's stream of queries, the content on reviewed pages, and long-term medical search behaviors. Our findings have implications for reducing costly and unnecessary healthcare resource utilization through refinements of ranking algorithms and search interfaces.
Ultra‐Narrow‐Band Blue‐Emitting Oxoberyllates AELi2[Be4O6]:Eu2+ (AE=Sr,Ba) Paving the Way to Efficient RGB pc‐LEDs (2018)

Highly efficient phosphor-converted light-emitting diodes (pc-LEDs) are popular in lighting and high-tech electronics applications. The main goals of present LED research are increasing light quality, preserving color point stability and reducing energy consumption. For those purposes excellent phosphors in all spectral regions are required. Here, we report on ultra-narrow band blue emitting oxoberyllates AELi<sub>2</sub> [Be<sub>4</sub> O<sub>6</sub> ]:Eu<sup>2+</sup> (AE=Sr,Ba) exhibiting a rigid covalent network isotypic to the nitridoalumosilicate BaLi<sub>2</sub> [(Al<sub>2</sub> Si<sub>2</sub> )N<sub>6</sub> ]:Eu<sup>2+</sup> . The oxoberyllates' extremely small Stokes shift and unprecedented ultra-narrow band blue emission with fwhm ≈25 nm (≈1200 cm<sup>-1</sup> ) at λ<sub>em</sub> =454-456 nm result from its rigid, highly condensed tetrahedra network. AELi<sub>2</sub> [Be<sub>4</sub> O<sub>6</sub> ]:Eu<sup>2+</sup> allows for using short-wavelength blue LEDs (λ<sub>em</sub> <440 nm) for efficient excitation of the ultra-narrow band blue phosphor, for application in violet pumped white RGB phosphor LEDs with improved color point stability, excellent color rendering, and high energy efficiency.
Data reorganization in memory using 3D-stacked DRAM (2015)

In this paper we focus on common data reorganization operations such as shuffle, pack/unpack, swap, transpose, and layout transformations. Although these operations simply relocate the data in the memory, they are costly on conventional systems mainly due to inefficient access patterns, limited data reuse and roundtrip data traversal throughout the memory hierarchy. This paper presents a two pronged approach for efficient data reorganization, which combines (i) a proposed DRAM-aware reshape accelerator integrated within 3D-stacked DRAM, and (ii) a mathematical framework that is used to represent and optimize the reorganization operations. We evaluate our proposed system through two major use cases. First, we demonstrate the reshape accelerator in performing a physical address remapping via data layout transform to utilize the internal parallelism/locality of the 3D-stacked DRAM structure more efficiently for general purpose workloads. Then, we focus on offloading and accelerating commonly used data reorganization routines selected from the Intel Math Kernel Library package. We evaluate the energy and performance benefits of our approach by comparing it against existing optimized implementations on state-of-the-art GPUs and CPUs. For the various test cases, in-memory data reorganization provides orders of magnitude performance and energy efficiency improvements via low overhead hardware.
Rapid Circadian Entrainment in Models of Circadian Genes Regulation (2019)

The light-based minimum-time circadian entrainment problem for mammals, Neurospora, and Drosophila is studied based on the mathematical models of their circadian gene regulation. These models contain high order nonlinear differential equations. Two model simplification methods are applied to these high-order models: the phase response curves (PRC) and the Principal Orthogonal Decomposition (POD). The variational calculus and a gradient descent algorithm are applied for solving the optimal light input in the high-order models. As the results of the gradient descent algorithm rely heavily on the initial guesses, we use the optimal control of the PRC and the simplified model to initialize the gradient descent algorithm. In this paper, we present: (1) the application of PRC and direct shooting algorithm on high-order nonlinear models; (2) a general process for solving the minimum-time optimal control problem on high-order models; (3) the impacts of minimum-time optimal light on circadian gene transcription and protein synthesis.
Modeling motor learning connectivity using coordinate-based meta-analysis and TMS/PET (2009)

BrainMap is a database of peak activation locations and metadata reported in functional neuroimaging studies, which was designed to develop and promote coordinate-based meta-analysis techniques. Here, we demonstrate the activation likelihood estimation (ALE) method in a meta-analysis of published TMS/PET studies. Using the results of this meta-analysis, we constructed a data-driven model of motor connectivity in TMS/PET data in which stimulation was delivered to RM1 before and after motor skill acquisition. A hybrid motor connectivity model of pre- and post-learning was generated to identify specific pathways most affected by the mechanisms involved in the motor learning process.
Closed-loop control for adaptive optics wavefront compensation in highly scintillated conditions (2003)

Conventional adaptive optics methods for controlling the phase control element based on least-squares reconstructions of the measured residual phase error exhibit poor performance as scintillation becomes strong. This paper compares the performance of various closed-loop control methods for different phase sensor types (self-referencing interferometer, shearing, and Shack-Hartmann interferometers), and for both conventional and segmented piston-type deformable mirrors (DMs). Significant performance improvements are demonstrated using a weighted least-squares reconstructor that adaptively optimizes the weights at each frame based on the intensities associated with each phase difference measurement and their sums around closed loops. Although the reconstructors considered do not explicitly place branch-cuts in the reconstructed residual phase, branch-cut like features can appear in both the single frame reconstructions and the closed-loop actuator commands. It is also found that at higher Rytov numbers, segmented piston-type DMs outperform conventional deformable mirrors. It is believed that conventional DMs suffer a fitting error associated with branch cuts in the actuator commands that the piston-type DMs are immune to. Performance trends corresponding to self-referencing interferometers provides a useful benchmark since, unlike Shack-Hartmann and shearing interferometers, the phase measurements are not corrupted by scintillation effects.
FDTD analysis of reflectarray radiating cells (2005)

This paper proposes an alternative method using FDTD. This method consists in illuminating a single cell of the array and calculating the reflected wave in the presence of the nearest neighbour cells (identical or not). It permits to obtain the radiation of a surrounded cell in all directions and for any incidence of the incoming wave. As an illustration, the method is applied to two resonant structures, a simple patch loaded with a slot and a triple patch loaded with two slots. These cells are proposed as test structures for the ACE (Antenna Center of Excellence, European NoE) software benchmarking.
On-demand droplet splitting using surface acoustic waves (2016)

We demonstrated the operation of an acoustomicrofluidic device composed of a polydimethylsiloxane (PDMS) microchannel and a slanted-finger interdigitated transducer (SF-IDT), for the on-demand splitting of droplets in an active, accurate, rapid, and size-controllable manner. A narrow beam of surface acoustic waves (SAWs) that emanated from the SF-IDT exerted an acoustic radiation force (ARF) on the droplet's water-oil interface due to the acoustic contrast between the two fluids. The ARF split the mother droplet into two or more daughter droplets of various volumes in a split ratio that was readily controlled by varying the applied voltage or the flow rate. Theoretical estimates of the ARF acting on the droplet interface were used to investigate the mechanism underlying the droplet splitting properties and size control. The versatility of the acoustomicrofluidic device operation was demonstrated by selectively pushing/placing a suspended polystyrene particle into a specific/preferred split daughter droplet using the direct ARF acting on the particle.
Patient Opioid Requirements Are Often Far Less Than Their Discharge Prescription After Orthopaedic Surgery: the Results of a Prospective Multicenter Survey (2020)

Most patients used far fewer opioids after orthopaedic surgery than prescribed. These data have informed further improvement of our opioid prescription guidelines to more precisely align with anticipated procedure- and patient-specific requirements.
<title>Beam-monitoring system using microapertures for electron-beam lithography</title> (2000)

A new beam-monitoring system for electron-beam lithography is proposed, which can be used for the variably shaped beam (VSB) method, the character projection (CP) method and the electron- beam mask (EB mask) projection method. The system is composed of micro-apertures and a detector placed below the micro- aperture, which is installed at a focal plane of a mask writer. The micro-apertures are formed on a 1-micrometer-thick Si film on which two 200-nm-thick W layers are deposited. A shaped beam is scanning over the micro-aperture, and the electrons that pass through the micro-aperture are directly detected with the detector, so that the two-dimensional shape and size of the beam are measured. The contrast and the signal-to-noise ratio obtained by this system are greatly superior to those obtained by the conventional mark-scanning method.
Integration of reduced graphene oxide into organic field-effect transistors as conducting electrodes and as a metal modification layer (2009)

The characteristics of thin-film transistors (TFTs) with pentacene active layers and source/drain contact layers consisting of either Au, Au coated with highly reduced graphene oxide (HRG), or plain HRG, are compared. It is shown that the incorporation of HRG as an interfacial material between gold source/drain contacts and pentacene in TFT devices results in improved electrical characteristics. The effect of the HRG layer is to improve the gold/pentacene interface leading to better charge injection, lower losses at the interface, and, consequently, higher effective carrier mobility.
Human Kallikrein Gene Delivery Attenuates Hypertension, Cardiac Hypertrophy, and Renal Injury in Dahl Salt-Sensitive Rats (1998)

The tissue kallikrein-kinin system has been documented to be involved in the pathogenesis of hypertension and renal diseases. To investigate the protective effects of kallikrein gene delivery on salt-induced renal damage, cardiac dysfunction, and hypertension, adenovirus harboring the human tissue kallikrein gene under the control of the cytomegalovirus promoter Ad.CMV-cHK was delivered into Dahl salt-sensitive (Dahl-SS) rats fed to a high-salt (4% NaCl) diet. A single intravenous injection of Ad.CMV-cHK resulted in a significant reduction of blood pressure beginning 2 days post injection and the effect lasted for 4 weeks. The human kallikrein mRNA was detected in rat heart, kidney, lung, liver, and adrenal gland; immunoreactive human kallikrein can be measured in the liver, kidney, sera, and urine of rats receiving kallikrein gene delivery. Following Ad.CMV-cHK injection, a significant increase in urine excretion, urinary sodium output, kinin, and cGMP level was observed. Kallikrein gene delivery caused a significant reduction in the left ventricular mass and cardiomyocyte size as well as inhibition of glomerular sclerotic lesions and tubular dilatation. This study shows that adenovirus-mediated gene delivery in Dahl-SS rats fed a high-salt diet resulted in (i) prolonged reduction of blood pressure and increased urinary kinin and cGMP levels, consistent with blood pressure reductions mediated via kinin through a cGMP-dependent signal transduction pathway, (ii) inhibition of cardiac hypertrophy, and (iii) attenuation of renal injury. The ability of kallikrein gene transfer to produce a wide spectrum of beneficial effects makes it an excellent candidate in treating salt-related hypertension as well as cardiovascular and renal diseases.