gebhart/patrepeval huggingface dataset:
1962. TRAIL Level and ImmunoXpert™ Score Complement Molecular Viral Detection in the Classification of Febrile Children: An Interim Analysis From the AutoPilotDx-Study (2018)

Differentiating between viral and bacterial etiology is essential in order to enable the adequate use of antibiotics. Previous studies showed that TNF-related apoptosis induced ligand (TRAIL) can serve as a useful biomarker for distinguishing between bacterial and viral infections when combined with IP-10 and CRP (ImmunoXpert™). Here we evaluate the potential of a new proteomic fingerprints in children with suspected viral and bacterial infections that had a confirmed viral detection. In the prospective multinational multicenter study “AutoPilot-Dx” (NCT03052088) we aim to validate the diagnostic accuracy of the ImmunoXpert™ test. Infection etiology was assigned by majority adjudication of three experts based on comprehensive clinical and laboratory investigation. Viruses were detected using multiplex-PCR applied to nasopharyngeal swabs (Allplex™, Seegene). We performed an interim analysis of the first 134 febrile children recruited that had both PCR viral detection and etiology determination. TRAIL, IP-10, CRP and ImmunoXpert™ values were measured via a Tecan EVO75 ELISA platform. Bacterial diagnoses were assigned by the experts to 29%, 29% and 25% of patients with adenovirus (ADV), rhinovirus (RV), and respiratory syncytial virus (RSV) detection, respectively. Children with a viral infection including ADV, RSV, and RV had significantly lower ImmunoXpert™ scores as compared with children with a bacterial infection. Notably, TRAIL levels were markedly increased in viral infections as compared with bacterial infection, irrespective of the detected virus. Classification of viral infections correlated significantly with elevated TRAIL levels and low ImmunoXpert™ scores. The differential expression of TRAIL in response to viral vs. bacterial infections can complement molecular viral detection, appears useful in the diagnostic workup for febrile children and may reduce antibiotic misuse. L. Etshtein, MeMed Diagnostics: Employee, Salary. N. Mastboim, MeMed Diagnostics: Employee, Salary. A. Cohen, MeMed Diagnostics: Employee, Salary. E. Simon, MeMed: Employee, Salary. O. Boico, MeMed Diagnostics: Employee, Salary. L. Shani, MeMed Diagnostics: Employee, Salary. T. Gottlieb, MeMed Diagnostics: Employee, Salary. R. Navon, MeMed Diagnostics: Employee, Salary. K. Oved, MeMed Diagnostics: Board Member, Employee and Shareholder, Salary. E. Eden, MeMed Diagnostics: Board Member, Employee and Shareholder, Salary.
Effects of diethyldithiocarbamate and nine other nucleophiles on the intersubunit protein cross-linking and inactivation of purified human alpha 2-macroglobulin by cis-diamminedichloroplatinum(II). (1984)

The cross-linking and inactivation of the plasma protein alpha 2-macroglobulin by cis-diamminedichloroplatinum(II) (cisplatin; Gonias, S. L., and Pizzo, S. V. J. Biol. Chem., 256: 12478-12484, 1981) was used to study platinum(II)-protein binding in the presence of compounds of therapeutic or biochemical significance. Diethyldithiocarbamate, potassium cyanide (KCN), sodium thiocyanate, L-methionine, N-acetyl-L-cysteine, 2-aminoethanethiol, L-cysteine, L-lysine, L-histidine, and L-arginine demonstrated variable capacity to inhibit reaction of cisplatin with protein and to reverse bidentate platinum(II)-protein binding in the in vitro model system. alpha 2-Macroglobulin lost 90% of its activity and was completely cross-linked, as determined with polyacrylamide gel electrophoresis, after reaction with cisplatin (0.6 to 1.0 mM). When diethyldithiocarbamate (4 to 15 mM) was incubated with alpha 2-macroglobulin and cisplatin, protein inactivation and cross-linking were totally prevented. In experiments with alpha 2-macroglobulin-platinum(II) complex, purified by gel filtration chromatography, 1.0 mM diethyldithiocarbamate completely reactivated the protein and eliminated nearly all of the intersubunit cross-links. Only KCN was comparably effective as an inhibitor of the reaction of cisplatin with alpha 2-macroglobulin; however, KCN was significantly less reactive with preformed platinum(II)-protein bonds than was diethyldithiocarbamate. N-Acetyl-L-cysteine, 2-aminoethanethiol, and L-cysteine were moderately reactive with free cisplatin. This group of compounds also demonstrated a low level of reactivity with the purified alpha 2-macroglobulin-platinum(II) complex. L-Methionine inhibited reaction of cisplatin with the protein, but was ineffective at reversing the reaction in the concentration range studied. The remaining compounds had little or no effect on the reaction of cisplatin with alpha 2-macroglobulin. The ability of diethyldithiocarbamate to displace nucleophilic protein groups from highly stable bonds with platinum(II) may be critical in its function as a rescue agent, limiting cisplatin toxicity towards nontumor cells.
Expanding the Process Window and Reducing the Optical Proximity Effect by Post-Exposure Delay (2001)

In this investigation, a novel idea had been proposed to expand the process window and reduce the optical proximity effect (OPE) by employing post-exposure delay (PED). Our previous work presented a model to specify the resist linewidth according to PED time based on the neutralization mechanism of organic base and photogenerated acid. Based on the model, the exposure latitude and depth of focus can be extended for various pattern sizes by applying PED on linewidth broadening. Moreover, the dense-iso critical dimension bias, which is caused by OPE, can also be reduced when PED is performed. © 2001 The Electrochemical Society. All rights reserved.
Multifrequency Acousto-Optic Diffraction in Wideband Bragg Cells (1983)

A fundamental limit for the dynamic range of acousto-optic signal processor is the intermodulation products (IMPs) generated by nonlinearities in the Bragg cells when simultaneous signals are present. For wideband Bragg cells it was found the dominant contribution of the IMPS is due to acoustic nonlinearities in the Bragg cell medium. A coupled mode analysis is presented for the nonlinear interaction of multiple acoustic waves at different c arrier frequencies. Approximate truncated s eries solutions of the dominant IMPs are derived for two signals case. Experimental results obtained with Te02 and GaP cells are presented.
A New Synthesis of 1,4-Thiazin-3-ones by a Novel Rearrangement of 1,4-Oxathiins (1996)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTA New Synthesis of 1,4-Thiazin-3-ones by a Novel Rearrangement of 1,4-OxathiinsHoh-Gyu Hahn, Kee Dal Nam, Heduck Mah, and Jum Jung LeeView Author Information Organic Chemistry Laboratory, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, 136−791, Seoul, KoreaCite this: J. Org. Chem. 1996, 61, 11, 3894–3896Publication Date (Web):May 31, 1996Publication History Received20 September 1995Published online31 May 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jo951723hhttps://doi.org/10.1021/jo951723hbrief-reportACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views209Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aromatic compounds,Hydrocarbons,Lipids,Rearrangement,Solvents Get e-Alerts
(Polystyrylbipyridine)(tetracarbonyl)tungsten. An active, reusable heterogeneous catalyst for metathesis of internal olefins (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT(Polystyrylbipyridine)(tetracarbonyl)tungsten. An active, reusable heterogeneous catalyst for metathesis of internal olefinsSeizo Tamagaki, Roger J. Card, and Douglas C. NeckersCite this: J. Am. Chem. Soc. 1978, 100, 21, 6635–6639Publication Date (Print):October 1, 1978Publication History Published online1 May 2002Published inissue 1 October 1978https://pubs.acs.org/doi/10.1021/ja00489a013https://doi.org/10.1021/ja00489a013research-articleACS PublicationsRequest reuse permissionsArticle Views147Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Analysis of a 1060-nm Nd:SiO/sub 2/ superfluorescent fiber laser (1989)

This CW source is made of a single-mode Nd-doped silica fiber end-pumped near 830 nm by a dye laser, with a thin high reflector placed against its input end for enhanced conversion. At the maximum output power of 13 mW, obtained with a pump power of 75 mW, the emission linewidth is still as broad as 16 nm, and the pump-to-signal conversion efficiency approaches the quantum limit of 78%. A simple model of superfluorescence in fibers, which relates the source emission characteristics to the fiber single-pass gain, is also presented. The single-pass gain, measured to be 0.27 dB/mW, was used to fit the model to the data. A good agreement is found for the nonlinear output versus input power curves of the sources, but it appears that the emission linewidth does not narrow with increasing pump power as fast as expected. Based on these results and an existing model of gain in single-mode fibers, it is suggested that simple improvements in the fiber design may reduce the pump requirement of this source and make laser-diode pumping possible.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
ChemInform Abstract: Cu(I)‐Catalyzed Huisgen Azide—Alkyne 1,3‐Dipolar Cycloaddition Reaction in Nucleoside, Nucleotide, and Oligonucleotide Chemistry (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Étude par RPE du mouvement brownien au sein des gels de V2O5 (1985)

L'étude par RPE des xérogels V2O5, nH2O a permis de mettre en évidence la solvatation des sites V(IV) lorsque n > 1.8. Cette solvatation entraîne un mouvement des espèces paramagnétiques qui a été analysé selon le modèle de Kivelson. Ce mouvement pourrait être dû à des ions vanadyles encore fixés aux feuillets composant le gel, ou intercalés entre eux. Il se développe dès qu'une couche d'eau est intercalée et semble devenir plus complexe lorsqu on passe du gonflement discontinu au gonflement continu. Les phénomènes d'interstratification qui apparaissent alors pourraient entraîner une distribution des temps de corrélation du mouvement des espèces paramagnétiques.
The Effects of Heat Activation on Bacillus Spore Germination, with Nutrients or under High Pressure, with or without Various Germination Proteins (2015)

Nutrient germination of spores of Bacillus species occurs through germinant receptors (GRs) in spores' inner membrane (IM) in a process stimulated by sublethal heat activation. Bacillus subtilis spores maximum germination rates via different GRs required different 75 °C heat activation times: 15 min for l-valine germination via the GerA GR and 4 h for germination with the L-asparagine-glucose-fructose-K(+) mixture via the GerB and GerK GRs, with GerK requiring the most heat activation. In some cases, optimal heat activation decreased nutrient concentrations for half-maximal germination rates. Germination of spores via various GRs by high pressure (HP) of 150 MPa exhibited heat activation requirements similar to those of nutrient germination, and the loss of the GerD protein, required for optimal GR function, did not eliminate heat activation requirements for maximal germination rates. These results are consistent with heat activation acting primarily on GRs. However, (i) heat activation had no effects on GR or GerD protein conformation, as probed by biotinylation by an external reagent; (ii) spores prepared at low and high temperatures that affect spores' IM properties exhibited large differences in heat activation requirements for nutrient germination; and (iii) spore germination by 550 MPa of HP was also affected by heat activation, but the effects were relatively GR independent. The last results are consistent with heat activation affecting spores' IM and only indirectly affecting GRs. The 150- and 550-MPa HP germinations of Bacillus amyloliquefaciens spores, a potential surrogate for Clostridium botulinum spores in HP treatments of foods, were also stimulated by heat activation.
GS03 Fabrication of Sandwich Panel Consisting of ADC12 porous Al/dense ADC6 Plate (2013)

Porous aluminum is a lightweight material with high energy absorption properties. In this study, sandwich panel consisting of ADC 12 porous aluminum and dense ADC6 plates was fabricated by friction stir processing (FSP) route. In the FSP route, lightweight sandwich panel, which has ADC 12 porous aluminum core with porosity of approximately 70 %, can be successfully obtained. Also, fabricated sandwich panel has good bonding between porous aluminum core and dense ADC6 plates. From the result of tensile test of obtained sandwich panel, fracture occurred in porous aluminum core. Therefore, it was shown that the strength of bonded interface is higher than the strength of porous aluminum core with porosity of approximately 70 %.
Cryochemical studies of zerovalent copper-ethylene complexes, [C2H4]nCu and [C2H4]mCu2 [where n = 1-3; m = 4 or 6], and their use in forming copper clusters. Localized bonding models for ethylene chemisorption onto bulk copper (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCryochemical studies of zerovalent copper-ethylene complexes, [C2H4]nCu and [C2H4]mCu2 [where n = 1-3; m = 4 or 6], and their use in forming copper clusters. Localized bonding models for ethylene chemisorption onto bulk copperGeoffrey A. Ozin, Helmhut. Huber, and Douglas. McIntoshCite this: Inorg. Chem. 1977, 16, 12, 3070–3078Publication Date (Print):December 1, 1977Publication History Published online1 May 2002Published inissue 1 December 1977https://pubs.acs.org/doi/10.1021/ic50178a018https://doi.org/10.1021/ic50178a018research-articleACS PublicationsRequest reuse permissionsArticle Views105Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Solid-state light phase detector (2003)

We demonstrate a solid-state device capable of unambiguously measuring the carrier-envelope phase of ultrashort (4-femtosecond), low-energy (unamplified) laser pulses using photoelectron emission from a gold surface in the multiphoton regime.
Supplementary Video 2 from Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues (2023)

&lt;p&gt;AVI file - 1261KB, Representative 3D RENDERING HFK EETE.&lt;/p&gt;
Evidence for precursor plasma formation resulting from heterogeneous current channels in wire array loads (1996)

The initial current flow in single and double wire loads exploded by current generators with dI/dt in the range of 1010–1012 A/s has been investigated using laser absorption and interferometric techniques. The results clearly show heterogeneous current channel formation with a plasma corona surrounding a predominantly neutral core. In the two wire load case, the corona is observed to separate from the core and prematurely implode on axis. Parasitic current channels were observed when material, outgassed by a low level prepulse current, is ionized to form a current carrying plasma channel that temporarily shields the wire from the main current pulse. In a complementary study on a terawatt generator, the radiation spectra from Mg coated Al wire array loads contained Mg K-shell lines 10 ns before similar Al lines were observed, confirming the load straggling effects implied by the laser imaging measurements. The results are consistent with theoretical predictions of heterogeneous current channels and precursor plasma formation that lead to a softer implosion, reduced ion density, and reduced x-ray yield.
University/Industry Research Highlights (2007)

We present a research effort to develop a photonic integrated circuit technology on silicon. We review several novel devices, including electrically pumped hybrid silicon evanescent lasers, amplifiers, and photodetectors. These devices form the basis of a low-cost, scalable solution for hybrid integration on a silicon platform.
Theoretical Analysis of Multi-Carrier Agile Phased Array Radar (2020)

Modern radar systems are expected to operate reliably in congested environments under cost and power constraints. A recent technology for realizing such systems is frequency agile radar (FAR), which transmits narrowband pulses in a frequency hopping manner. To enhance the target recovery performance of FAR in complex electromagnetic environments, and particularly, its range-Doppler recovery performance, multi-Carrier AgilE phaSed Array Radar (CAESAR) was proposed. CAESAR extends FAR to multi-carrier waveforms while introducing the notion of spatial agility. In this paper, we theoretically analyze the range-Doppler recovery capabilities of CAESAR. Particularly, we derive conditions which guarantee accurate reconstruction of these range-Doppler parameters. These conditions indicate that by increasing the number of frequencies transmitted in each pulse, CAESAR improves performance over conventional FAR, especially in complex environments where some radar measurements are severely corrupted by interference.
Measurement of defibrillation shock potential distributions and activation sequences of the heart in three dimensions (1988)

The authors note that knowledge of the extracellular potential gradient field of the defibrillation shock and the cardiac-tissue response to the shock should lead to better understanding of the mechanism of defibrillation and stimulate improvement of defibrillation techniques. By measuring the potential distribution of the defibrillation shock throughout the heart and the location of the recording electrodes, the potential gradient field may be calculated. By recording local electrograms throughout the heart immediately before and after the shock, the tissue response to the shock can be evaluated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A prototype 3D optically interconnected neural network (1994)

We report the implementation of a prototype three-dimensional (3D) optoelectronic neural network that combines free-space optical interconnects with silicon-VLSI-based optoelectronic circuits. The prototype system consists of a 16-node input, 4-neuron hidden, and a single-neuron output layer, where the denser input-to-hidden-layer connections are optical. The input layer uses PLZT light modulators to generate optical outputs which are distributed over an optoelectronic neural network chip through space-invariant holographic optical interconnects. Optical interconnections provide negligible fan-out delay and allow compact, purely on-chip electronic H-tree type fan-in structure. The small prototype system achieves a measured 8-bit electronic fan-in precision and a calculated maximum speed of 640 million interconnections per second. The system was tested using synaptic weights learned off system and was shown to distinguish any vertical line from any horizontal one in an image of 4/spl times/4 pixels. New, more efficient light detector and small-area analog synapse circuits and denser optoelectronic neuron layouts are proposed to scale up the system. A high-speed, feed-forward optoelectronic synapse implementation density of up to 10/sup 4//cm/sup 2/ seems feasible using new synapse design. A scaling analysis of the system shows that the optically interconnected neural network implementation can provide higher fan-in speed and lower power consumption characteristics than a purely electronic, crossbar-based neural network implementation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Failure detection methods to predict loss of control involving human-interface devices. II. Empirical validation (1998)

Part I, published in the same conference, addressed certain theoretical issues concerning the design of a human-interface device to help predict the loss of tracking control when a human operator is involved in a position tracking scenario. This part describes the empirical validation of such a system with human subjects within a laboratory scenario. Such an apparatus can be used to help mitigate the loss of control by giving the operator a warning a priori or possibly used to adapt a display or controller (adjust the automation level).
Rectal endoscopy findings following stereotactic body radiation therapy for clinically localized prostate cancer (2013)

The Georgetown Institutional Review Board has approved this retrospective study (IRB 2009-510).