gebhart/patrepeval huggingface dataset:
Hybrid electro-refraction and electro-absorption modulators on silicon (2011)

We demonstrate high speed electro-refraction and electro-absorption modulators on the hybrid silicon platform. These modulators use distributed electrodes and have good performance for bit rates up to 40 Gb/s or more.
Optimization of the woven fibre-immersed membrane bioreactor (WF-IMBR) (2017)

In this research, the woven fibre microfiltration (WFMF) fabric which is produced locally in South Africa is used as a membrane material. It is cheaper in price in comparison with the current commercial membrane materials that are in use. The WFMF is also more robust when compared with the commercial membrane materials thus is able to withstand harsh working conditions. From previous studies on the WFMF, it has been shown that it can be used as a membrane material without any compromise to permeate quality. This research seeks to optimize the working conditions of this membrane material (WFMF) with an aim of achieving lower running costs and better anti fouling strategies in comparison to the commercial MBRs. The objectives and aims of this research was to come up with a MBR system whose running cost is lower than that for the commercial systems, which can be adapted for use in any environment, especially in the hardship regions where its robustness would be an added advantage. The performance of the WFMF submerged MBR was also optimised including antifouling operating regimes. This study was done in a pilot plant that was set up at Veolia wastewater treatment plant, Durban Metro Southern Works. The feed water for the pilot plant was pumped from the return activated sludge mixing chamber by means of a submersible pump. The MLSS concentration of the feed water was about 12 g/l. The various investigations that were conducted in the course of this research included the effect of spacing between membrane modules, relaxation steps and frequencies, evaluation of aeration rates and evaluation of coarse vs. fine bubbles which were all aimed at optimizing the performance of the immersed WFMF MBR. The permeate was checked for turbidity and COD levels to ensure that they were within the accepted water standards. From the experiments it is shown that the critical flux increased with an increase in aeration rate which is in concurrence with the literature and a starting flux of 30 LMH was chosen for the running of the pilot plant for the various experimental runs to be carried out. For the pipe diffuser height effect experimental run, the best results were achieved at a height of 5 cm below the membrane modules and the use of a pipe diffuser gave better results than the use of a disc diffuser. For the membrane module spacing effect the best results were obtained at the smallest possible width i.e. 3.5 mm. The best relaxation step sequence was found to be 9 mins on and 1 min off. COD, turbidity and DO was continuously determined during the course of the experimentation. Further studies should be done on use of the disc diffuser with increased surface area of aeration holes and also hole sizes of smaller diameters to check on its effectiveness as a means of reducing fouling on the membrane surface.
GPU accelerated multilevel fast physical optics algorithm for radiation from non-planar apertures (2015)

Acceleration of the multilevel physical optics (MLPO) algorithm using the single instruction multiple threads (SIMT) computing scheme, as implemented on a CUDA-architecture based GPU accelerator is presented. The MLPO algorithm already reduces the computing complexity (CC) of the physical optics based radiation pattern calculation algorithm to O(N <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> logN), as compared to the O(N <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> ) or O(N <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> ) CC of the straight-forward implementation (depending on the nature of the problem). Here, N=kR, R being the radius of the smallest sphere containing the radiating aperture and k - the wavenumber. By implementing on a GPU, the MLPO algorithm is accelerated tenfold, allowing fast and efficient evaluation of physical optics integrals. Performance improving optimizations of the parallel code are described. Finally, a timing model that provides estimates of the GPU computation time is presented and compared to the actual GPU run-time measurements.
Partial response or better at six months is prognostic of superior progression‐free survival in Waldenström macroglobulinaemia patients treated with ibrutinib (2020)

Ibrutinib is associated with durable responses in patients with Waldenström macroglobulinaemia (WM). We hypothesized that response depth is predictive of progression-free survival (PFS) in WM patients treated with ibrutinib. Using landmark analyses, we evaluated response depth in two cohorts of WM patients treated with ibrutinib monotherapy. The learning cohort was composed of 93 participants from two clinical trials, and the validation cohort of 190 consecutive patients treated off clinical trial. Rates of partial response (PR) or better at six months in learning and validation cohorts were 64% and 71% respectively (P = 0·29). In the learning cohort, three-year PFS rates for patients who attained PR or better at six months versus not were 81% and 57% respectively (P = 0·009). In the validation cohort, three-year PFS rates for patients who attained PR or better at six months versus not were 83% and 54% respectively (P = 0·008). In multivariate analyses, attaining PR or better at six months was associated with superior PFS in the learning [hazard ratio (HR) 0·38; P = 0·01] and validation cohorts (HR 0·18; P = 0·004). Attaining PR at six months on ibrutinib emerges as an intermediate outcome of interest and should be validated as surrogate for PFS in clinical trials evaluating Bruton tyrosine kinase inhibitors in WM.
CCDC 269776: Experimental Crystal Structure Determination (2006)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Dynamic and adaptive QoE management for OTT application sessions in LTE (2016)

Radio resources in Long Term Evolution (LTE) systems are distributed among User Equipments (UE) without considering the application and content being transmitted. When the radio capacity is fully utilized, the bearer based service strategy aiming to maximize the spectral efficiency may not support good customer experience for popular Over The Top (OTT) applications where each session has an individual and highly dynamic bandwidth demand. In this paper, we argue that maximizing the system efficiency cannot be decoupled from customer experience, therefore maximized spectral efficiency does not necessarily improve the service quality perception of end users. Furthermore, we show that the existing LTE QoS architecture does not bring sufficient benefit on this matter and conclude that customer experience is a better system level target. Such operation requires a different service paradigm where resources are allocated to individual application sessions adaptively and dynamically by understanding their specific requirements. We propose a Quality of Experience (QoE) Manager that can deliver superior QoE for each session by loosening the radio efficiency targets to maximize the customer experience. Still, the radio scheduler retains sufficient freedom to optimize on channel diversity. The solution is demonstrated via simulations including the successful management of encrypted YouTube downloads.
A Multicomponent Ni‐, Zr‐, and Cu‐Catalyzed Strategy for Enantioselective Synthesis of Alkenyl‐Substituted Quaternary Carbons (2014)

Abstract The availability of enantiomerically enriched carbonyl‐containing compounds is essential to the synthesis of biologically active molecules. Since catalytic enantioselective conjugate addition (ECA) reactions directly generate the latter valuable class of molecules, the design and development of such protocols represents a compelling objective in modern chemistry. Herein, we disclose the first solution to the problem of ECA of alkenyl groups to acyclic trisubstituted enones, an advance achieved by adopting an easily modifiable and fully catalytic approach. The requisite alkenylaluminum reagents are synthesized with exceptional site‐ and/or stereoselectivity by a Ni‐catalyzed hydroalumination process, and the necessary enones are prepared through a site‐ and stereoselective zirconocene‐catalyzed carboalumination/acylation reaction. The all‐catalytic procedure is complete within four hours, furnishing the desired products in up to 77 % overall yield and 99:1 enantiomeric ratio.
A Straightforward Approach for Cellular‐Uptake Quantification (2010)

Putting a number on it: MALDI-TOF MS enabled direct quantification of the cellular uptake of cell-penetrating peptides (CPPs) by MDA-MB-231 breast cancer cells. This sensitive general strategy (see schematic representation), which requires no purification or separation steps, relies on the enhancement and discrimination of the MS signals of an α-cyano-4-hydroxycinnamic acid tag in a neutral α-cyano-4-hydroxycinnamic methyl ester matrix.
ADPKD: Prototype of Cardiorenal Syndrome Type 4 (2010)

The cardiorenal syndrome type 4 (Chronic Renocardiac Syndrome) is characterized by a condition of primary chronic kidney disease (CKD) that leads to an impairment of the cardiac function, ventricular hypertrophy, diastolic dysfunction, and/or increased risk of adverse cardiovascular events. Clinically, it is very difficult to distinguish between CRS type 2 (Chronic Cardiorenal Syndrome) and CRS type 4 (Chronic Renocardiac Syndrome) because often it is not clear whether the primary cause of the syndrome depends on the heart or the kidney. Autosomal dominant polycystic kidney disease (ADPKD), a genetic disease that causes CKD, could be viewed as an ideal prototype of CRS type 4 because it is certain that the primary cause of cardiorenal syndrome is the kidney disease. In this paper, we will briefly review the epidemiology of ADPKD, conventional and novel biomarkers which may be useful in following the disease process, and prevention and treatment strategies.
Mechanism of Induction of RNA Tumor Viruses by Halogenated Pyrimidines (1974)

Frome these studies on JLS V-9 cells, a number of conclusions can be drawn about the mechanism of MuLV induction by halogenated pyrimidines. The compounds can induce virus from otherwise healthy cells as long as deoxycytidine is present along with the inducing agent. The compounds must be present during the S phase of the cell cycle and must be incorporated into DNA in order to induce virus (Teich et al. 1973). Only one strand of DNA need be substituted by BrdU or IdU in order to induce virus, because a one-hour period of incorporation leads to induction. From these results it is possible to construct a model for how halogenated pyrimidines are able to induce viruses from otherwise uninfected cells. Because the critical period for the incorporation of the compound is a restricted segment of the S phase of the cell, there would appear to be a critical segment of the genetic information of the cell which, when substituted with BrdU or IdU, leads to a transcriptional derepression. Presumably the critical segment of DNA is either a controlling element of the integrated provirus or it is a separate gene which controls the expression of the integrated provirus. Whichever is true, these results strongly imply that the search for specific repressors of the segments of mammalian DNA is likely to be successful and that RNA tumor viruses may offer a system in which such repression systems can be identified and investigated.
The development of lhermitte's sign during cisplatin chemotherapy: Possible drug-induced toxicity causing spinal cord demyelination (1987)

Cisplatin is a recognized neurotoxic agent that commonly causes ototoxicity and peripheral neuropathy. In conjunction with characteristic peripheral neuropathy, two patients treated with high-dose cisplatin developed Lhermitte's sign, a manifestation of posterior column spinal cord pathology. After cisplatin therapy was stopped, this symptom gradually resolved. This suggests that at high doses cisplatin may also cause demyelinating central nervous system lesions involving the spinal cord.
Adaptively meshed boundary integral equation method for nonlinear magnetostatics (1990)

A general approach to the treatment of nonlinear problems in magnetostatics using boundary integral equation methods is discussed. Adaptive meshing is used to obtain a more optimal distribution of boundary elements using the dependent variable as the criterion. Permanent magnets are shown to be accurately modeled using this method. Example solutions are presented for a ring magnet in the vicinity of a ferromagnetic sphere. Forces are easily calculated using Maxwell stress and are seen to compare very well against measurement.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A Non-Parametric Bayesian Approach to Spike Sorting (2006)

In this work we present and apply infinite Gaussian mixture modeling, a non-parametric Bayesian method, to the problem of spike sorting. As this approach is Bayesian, it allows us to integrate prior knowledge about the problem in a principled way. Because it is non-parametric we are able to avoid model selection, a difficult problem that most current spike sorting methods do not address. We compare this approach to using penalized log likelihood to select the best from multiple finite mixture models trained by expectation maximization. We show favorable offline sorting results on real data and discuss ways to extend our model to online applications.
Regional Variations in Cartilage Mechanics and Composition Suggest a Sensitivity to Changes in Chronic Joint Loading Patterns (2009)

It has been suggested that variations in cartilage mechanical properties and biochemistry within a joint may be critical in understanding the implications of altered joint kinematics as a pathway to the initiation of knee osteoarthritis (OA) [1]. For example, the kinematic changes resulting from anterior cruciate ligament (ACL) injury have been suggested as a mechanism for the initiation of OA by altering chronic joint loading patterns in a tissue with low adaptation potential [1]. This mechanism would suggest that regions of cartilage subjected to different habitual post-natal mechanical loading might exhibit, among other things, differences in biochemical content and mechanical properties. The tibial plateau offers a good test bed to evaluate this mechanism since peripheral region articular cartilage (covered by the menisci) appears to experience lower contact pressures in vivo during weight-bearing activity than regions of cartilage exposed to cartilage-cartilage contact [2, 3]. Thus, the purpose of this study was to test the hypothesis that there are significant regional differences in cartilage mechanical properties (including dynamic shear modulus, phase shift angle, and equilibrium Young’s Modulus) and biochemistry (including collagen content, sulfated glycosaminoglycan (s-GAG) content, and water content) between the central and peripheral regions of the porcine tibial plateau.
Abstract CT304: Anti-prostate-specific membrane antigen (PSMA) monoclonal antibody J591 plus low-dose interleukin-2 (IL-2) in patients with recurrent prostate cancer (PC) (2014)

Abstract Purpose J591 is a deimmunized monoclonal antibody that recognizes the extracellular domain of prostate specific membrane antigen and was engineered to induce antibody-dependent cellular cytotoxicity (ADCC). Low dose IL-2 may enhance ADCC by the clonal expansion of natural killer (NK) cells. Immunotherapy may result in survival benefits independent of immediate response. This study was designed to evaluate the efficacy of J591 plus low-dose IL-2 in men with recurrent PC. Experimental Design Men with non-castrate PSA relapse or progressive metastatic castration-resistant PC (mCRPC) received low-dose subcutaneous IL-2 (1.2 x 106 IU/m2/day) daily for 8 weeks with weekly intravenous infusions of J591 (25 mg/m2) on weeks 4-6 (considered 1 cycle). A maximum of 3 cycles of therapy was delivered. Flow cytometry was used to assess NK cell fraction and PSA changes and survival were assessed. Results Seventeen men were treated between 2001-03 with at least 1 cycle (11 PSA relapse, 6 mCRPC) with 1 mCRPC patient invaluable for PSA response due to a protocol violation (9 received 2 cycles, 2 received 3 cycles). Toxicity was mild, mainly limited to fatigue and injection site reactions. PSA declined following therapy in 7 of 16 evaluable men (2 of 5 mCRPC). Flow cytometry revealed an average increase in absolute NK cell count of 107% at week 4 and 117% at the end of cycle 1. NK cell percent change had an inverse relationship with PSA (2-tailed Pearson correlation coefficient r = -0.46; P= 0.13). The actual vs. predicted survival for 5 of the 6 men with mCRPC disease was greater than predicted by the Halabi nomogram (Spearman correlation analysis r=0.29; P=0.57, i.e. nomogram did not predict survival). Conclusions The combination of J591 with low-dose IL-2 was well tolerated in patients with biochemical relapse and mCRPC. In addition, combination therapy expanded NK cell fraction which correlated with PSA decline. Interestingly, long term follow up reveals that 83% of the mCRPC group lived significantly longer than predicted, mostly in an era prior to the approval of life-prolonging therapy. These data support further testing of the hypothesis that PSMA-directed immunotherapy influences outcome in men with advanced PC. Citation Format: Yulian Khagi, Gurveen Kaur, Paul Christos, Naveed H. Akhtar, David M. Nanus, Neil H. Bander, Scott T. Tagawa. Anti-prostate-specific membrane antigen (PSMA) monoclonal antibody J591 plus low-dose interleukin-2 (IL-2) in patients with recurrent prostate cancer (PC). [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr CT304. doi:10.1158/1538-7445.AM2014-CT304
Influence of High Pressure Sliding and Rotary Swaging on Creep Behavior of P92 Steel at 500 °C (2021)

High-pressure sliding (HPS) and rotary swaging (RS) at room temperature were used to form severely deformed microstructures in martensitic creep-resistant P92 steel. The deformed microstructures contained markedly different ratios of low- and high-angle grain boundaries (LAGBs/HAGBs). The application of the RS method, with an imposed equivalent strain of 1.4, led to the formation of a heterogeneous microstructure with a high number of LAGBs, while the HPS method, with an imposed equivalent strain of 7.8, led to the formation of a relatively homogeneous ultrafine-grained microstructure with a significant predominance of HAGBs. Microstructure analyses after creep testing showed that the microstructure of RS- and HPS-processed P92 steel is quite stable, but a slight coarsening of subgrains and grains during creep testing can be observed. Constant load tensile creep tests at 500 °C and initial stresses ranging from 300 to 900 MPa revealed that the specimens processed by HPS exhibited higher creep strength (slower minimum creep rate) and ductility compared to the coarse-grained and RS-processed P92 steel. However, the HPS-processed P92 steel also exhibited lower values of stress exponent n than the other investigated states of P92 steel. For this reason, the differences in minimum creep rates determined for different states decrease with decreasing values of applied stress, and at applied stresses lower than 500 MPa, the creep resistance of the RS-processed state is higher than the creep resistance of the HPS-processed state.
Suppression of clutter by rank adaptive reweighted sparse coding (2017)

Echocardiographic image sequences are frequently corrupted by quasi-static artifacts known as “clutter”. These artifacts are superimposed on the moving myocardium and hinder useful diagnosis. Prior work has shown the efficacy of blind source separation methods to suppress clutter while retaining underlying signal. However, the same image may be corrupted with clutter from multiple mechanisms or sources. Consequently, the spatiotemporal characteristics of the clutter vary depending on the mechanism. In this paper, a method is proposed that progressively detects and removes clutter of increasing temporal rank using sparse coding. The performance was quantified in vitro by measuring the mean squared error with respect to a ground truth dataset with no clutter. The error with respect to the ground truth was reduced from 1.3×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> ± 4.7×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> a.u. to 2.2 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> ± 9.8×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> a.u. The average clutter reduction in vivo was 11.9±0.5 dB.
FaceBlit (2021)

We present FaceBlit---a system for real-time example-based face video stylization that retains textural details of the style in a semantically meaningful manner, i.e., strokes used to depict specific features in the style are present at the appropriate locations in the target image. As compared to previous techniques, our system preserves the identity of the target subject and runs in real-time without the need for large datasets nor lengthy training phase. To achieve this, we modify the existing face stylization pipeline of Fišer et al. [2017] so that it can quickly generate a set of guiding channels that handle identity preservation of the target subject while are still compatible with a faster variant of patch-based synthesis algorithm of Sýkora et al. [2019]. Thanks to these improvements we demonstrate a first face stylization pipeline that can instantly transfer artistic style from a single portrait to the target video at interactive rates even on mobile devices.