gebhart/patrepeval huggingface dataset:
Perfect single-sided radiation and absorption without mirrors (2016)

Highly directional radiation from photonic structures is important for many applications, including high-power photonic crystal surface-emitting lasers, grating couplers, and light detection and ranging devices. However, previous dielectric, few-layer designs only achieved moderate asymmetry ratios, and a fundamental understanding of bounds on asymmetric radiation from arbitrary structures is still lacking. Here, we show that breaking the 180° rotational symmetry of the structure is crucial for achieving highly asymmetric radiation. We develop a general temporal coupled-mode theory formalism to derive bounds on the asymmetric decay rates to the top and bottom of a photonic crystal slab for a resonance with arbitrary in-plane wavevector. Guided by this formalism, we show that infinite asymmetry is still achievable even without the need for back-reflection mirrors, and we provide numerical examples of designs that achieve asymmetry ratios exceeding 10[superscript 4]. The emission direction can also be rapidly switched from top to bottom by tuning the wavevector or frequency. Furthermore, we show that with the addition of weak material absorption loss, such structures can be used to achieve perfect absorption with single-sided illumination, even for single-pass material absorption rates less than 0.5% and without back-reflection mirrors. Our work provides new design principles for achieving highly directional radiation and perfect absorption in photonics.
Searching surveillance video (2007)

Surveillance video is used in two key modes, watching for known threats in real-time and searching for events of interest after the fact. Typically, real-time alerting is a localized function, e.g. airport security center receives and reacts to a “perimeter breach alert”, while investigations often tend to encompass a large number of geographically distributed cameras like the London bombing, or Washington sniper incidents. Enabling effective search of surveillance video for investigation & preemption, involves indexing the video along multiple dimensions. This paper presents a framework for surveillance search which includes, video parsing, indexing and query mechanisms. It explores video parsing techniques which automatically extract index data from video, indexing which stores data in relational tables, retrieval which uses SQL queries to retrieve events of interest and the software architecture that integrates these technologies.
Modeling catalytic gauze reactors: ammonia oxidation (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModeling catalytic gauze reactors: ammonia oxidationDaniel A. Hickman and Lanny D. SchmidtCite this: Ind. Eng. Chem. Res. 1991, 30, 1, 50–55Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/ie00049a008https://doi.org/10.1021/ie00049a008research-articleACS PublicationsRequest reuse permissionsArticle Views916Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Visible‐Light‐Driven Halogen Bond Donor Based Molecular Switches: From Reversible Unwinding to Handedness Inversion in Self‐Organized Soft Helical Superstructures (2019)

Visible-light-driven molecular switches endowing reversible modulation of the functionalities of self-organized soft materials are currently highly sought after for fundamental scientific studies and technological applications. Reported herein are the design and synthesis of two novel halogen bond donor based chiral molecular switches that exhibit reversible photoisomerization upon exposure to visible light of different wavelengths. These chiral molecular switches induce photoresponsive helical superstructures, that is, cholesteric liquid crystals, when doped into the commercially available room-temperature achiral liquid crystal host 5CB, which also acts as a halogen-bond acceptor. The induced helical superstructure containing the molecular switch with terminal iodo atoms exhibits visible-light-driven reversible unwinding, that is, a cholesteric-nematic phase transition. Interestingly, the molecular switch with terminal bromo atoms confers reversible handedness inversion to the helical superstructure upon irradiation with visible light of different wavelengths. This visible-light-driven, reversible handedness inversion, enabled by a halogen bond donor molecular switch, is unprecedented.
Figure S1 from A Somatostatin Receptor Subtype-3 (SST<sub>3</sub>) Peptide Agonist Shows Antitumor Effects in Experimental Models of Nonfunctioning Pituitary Tumors (2023)

&lt;p&gt;Validation by qPCR of SSTR3 gene silencing with two specific siRNAs using the BON-1 cell line.&lt;/p&gt;
Does the turing test demonstrate intelligence or not (2006)

The Turing Test has served as a defining inspiration throughout the early history of artificial intelligence research. Its centrality arises in part because verbal behavior indistinguishable from that of humans seems like an incontrovertible criterion for intelligence, a "philosophical conversation stopper" as Dennett says. On the other hand, from the moment Turing's seminal Mind article was published, the conversation hasn't stopped; the appropriateness of the Test has been continually questioned, and current philosophical wisdom holds that the Turing Test is hopelessly flawed as a sufficient condition for attributing intelligence. In this short article, I summarize for an artificial intelligence audience an argument that I have presented at length for a philosophical audience that attempts to reconcile these two mutually contradictory but well-founded attitudes towards the Turing Test that have been under constant debate since 1950.
Interactions of the XylS regulators with the C‐terminal domain of the RNA polymerase α subunit influence the expression level from the cognate Pm promoter (2001)

The Pseudomonas putida meta-cleavage operon encodes the enzymes for the catabolism of alkylbenzoates. Activation of meta-operon transcription is mediated by the XylS protein which, upon activation by effectors, binds two sites between -70 and -35 with respect to the main transcription initiation point at the Pm promoter. Two naturally occurring regulators, XylS and XylS1, that differ by only five amino acids, have been analyzed with regard to potential interactions of these positive regulators with the C-terminal domain of the alpha subunit of RNA polymerase (alpha-CTD). For these studies we expressed a derivative of alpha deprived of the entire C-terminal domain (alpha-Delta235) and found that expression from Pm with XylS or XylS1 was significantly decreased. To discern whether alpha-CTD activation depended on interactions with DNA and/or XylS proteins we tested a large collection of alanine substitutions within alpha-CTD. Most substitutions that had an effect on XylS and XylS1-dependent transcription were located in or adjacent to helix 1 and 4, which are known to be involved in alpha-CTD interactions with DNA. Two alanine substitutions in helix 3 (residues 287 and 291) identified a putative region of alpha-CTD/XylS regulator interactions.
Optical Magnetic Mirrors using All Dielectric Metasurfaces (2014)

Abstract not provided.
Towards energy-aware autonomic provisioning for virtualized environments (2010)

As energy efficiency and associated costs become key concerns, consolidated and virtualized data centers and clouds are attractive computing platforms for data- and compute-intensive applications. Recently, these platforms are also being considered for more traditional high-performance computing (HPC) applications. However, maximizing energy efficiency, cost-effectiveness, and utilization for these applications while ensuring performance and other Quality of Service (QoS) guarantees, requires leveraging important and extremely challenging tradeoffs. These include, for example, the tradeoff between the need to efficiently create and provision Virtual Machines (VMs) on data center resources and the need to accommodate the heterogeneous resource demands and runtimes of the applications that run on them. In this paper we propose an energy-aware online provisioning approach for HPC applications on consolidated and virtualized computing platforms. Energy efficiency is achieved using a workload-aware, just-right dynamic provisioning mechanism and the ability to power down subsystems of a host system that are not required by the VMs mapped to it. Our preliminary evaluations show that our approach can improve energy efficiency with an acceptable QoS penalty.
Assessment of the Radiochemical Design of Antibodies with a Metabolizable Linkage for Target-Selective Radioactivity Delivery (1998)

Interposition of a metabolizable linkage has been performed to reduce the hepatic radioactivity levels of radiolabeled antibodies. To estimate the validity of this strategy, a radioiodination reagent (HML) that provides a stable attachment for m-iodohippuric acid with proteins in plasma while facilitating rapid and selective release of the compound after lysosomal proteolysis in the liver was conjugated with a monoclonal antibody (mAb) against osteogenic sarcoma (OST7, IgG1). Radiolabeled OST7 conjugates with a plasma-labile ester bond for releasing m-iodohippuric acid (MIH), plasma-stable amide bonds for releasing radiometabolites of hepatobiliary excretion (MPH), or slow elimination rates from hepatocytes ([111In]EMCS-Bz-EDTA) were prepared with similar conjugation chemistry. The four radiolabeled OST7 conjugates were characterized both in vitro and in vivo. All the radiolabeled OST7 conjugates had similar radiochromatograms on size-exclusion HPLC and similar antigen binding affinities. While MIH-OST7 indicated accelerated clearance of radioactivity from the blood due to the release of m-iodohippurate, the rest of the three radiolabeled OST7 conjugates remained stable in serum incubation studies and had similar radioactivity elimination from the blood in vivo. When injected into normal mice, HML-OST7 demonstrated tissue-to-blood ratios of radioactivity similar to those of MIH-OST7 and significantly lower than those of the other two radiolabeled OST7 conjugates. In biodistribution studies in nude mice, both HML-OST7 and MIH-OST7 exhibited tumor-to-liver or tumor-to-intestine ratios of radioactivity higher than those of [111In]EMCS-Bz-EDTA-OST7 or MPH-OST7, respectively. HML-OST7, MPH-OST7, and [111In]EMCS-Bz-EDTA-OST7 indicated there were no changes in the radioactivity levels in the tumor between 24 and 48 h postinjection, whereas MIH-OST7 significantly decreased the radioactivity levels in the tumor at these time points. HML reduced the radioactivity levels in nontarget tissues without impairing the tumor radioactivity levels delivered by OST7. These findings indicated that the design of a radiolabeled mAb that is stable in plasma and liberates the radiometabolite of rapid urinary excretion constitutes an effective strategy for achieving target-selective radioactivity delivery.
A Multilevel Energy Buffer and Voltage Modulator for Grid-Interfaced Microinverters (2014)

Microinverters operating into the single-phase grid from solar photovoltaic (PV) panels or other low-voltage sources must buffer the twice-line-frequency variations between the energy sourced by the PV panel and that required for the grid. Moreover, in addition to operating over wide average power ranges, they inherently operate over a wide range of voltage conversion ratios as the line voltage traverses a cycle. These factors make the design of microinverters challenging. This paper presents a multilevel energy buffer and voltage modulator (MEB) that significantly reduces the range of voltage conversion ratios that the dc-ac converter portion of the microinverter must operate over by stepping its effective input voltage in pace with the line voltage. The MEB partially replaces the original bulk input capacitor, and functions as an active energy buffer to reduce the total size of the twice-line-frequency energy buffering capacitance. The small additional loss of the MEB can be compensated by the improved efficiency of the dc-ac converter stage, leading to a higher overall system efficiency. The MEB architecture can be implemented in a variety of manners, allowing different design tradeoffs to be made. A prototype microinverter incorporating an MEB, designed for 27 to 38 V dc input voltage, 230-V rms ac output voltage, and rated for a line cycle average power of 70 W, has been built and tested in a grid-connected mode. It is shown that the MEB can successfully enhance the performance of a single-phase grid-interfaced microinverter by increasing its efficiency and reducing the total size of the twice-line-frequency energy buffering capacitance.
Transcending the replacement paradigm of solid-state lighting (2008)

The field of photonics starts with the efficient generation of light. The generation of efficient yet highly controllable light can indeed be accomplished with light-emitting diodes (LEDs), which are, in principle, capable of generating white light with a 20 times greater efficiency than conventional light bulbs. Deployed on a global scale to replace conventional sources, such solid-state light sources will result in enormous benefits that, over a period of 10 years, include (1) gigantic energy savings of 1.9 x 1020 joule, (2) a very substantial reduction in global-warming CO2 emissions, (3) a strong reduction in the emission of pollutants such as acid-rain-causing SO2, mercury (Hg), and uranium (U), and (4) financial savings exceeding a trillion (10(12)) US$. These benefits can be accomplished by the "replacement paradigm" in which conventional light sources are replaced by more energy efficient, more durable, and non-toxic light sources. However, it will be shown that solid-state light sources can go beyond the replacement paradigm, by providing new capabilities including the control of spectrum, color temperature, polarization, temporal modulation, and spatial emission pattern. We will show that such future, "smart" light sources, can harness the huge potential of LEDs by offering multi-dimensional controllability that will enhance the functionality and performance of light sources in a wide range of applications. These applications include optical microscopy, imaging, display technologies, communications, networking, and transportation systems.
Photoluminescence Spectra of ZnO Films Doped with Li and Cl Atoms (2006)

ZnO films doped with Li and Cl atoms have been prepared by organometallic chemical vapor deposition method. In photoluminescence spectra of the doped ZnO films, strong emission appears at 376 nm which is slightly longer than that of free-excitons. As excitation intensity increases, a peak wavelength of the emission is shifted toward a shorter value. The emission near band-gap edge is assigned to radiative recombination via Li-Cl pairs.
A Novel GCAP1 Missense Mutation (L151F) in a Large Family with Autosomal Dominant Cone-Rod Dystrophy (adCORD) (2005)

A novel L151F mutation in the EF4 hand domain of GCAP1 is associated with adCORD. The clinical phenotype is characterized by early cone dysfunction and a progressive loss of rod function. The biochemical phenotype is best described as persistent stimulation of photoreceptor guanylate cyclase, representing a gain of function of mutant GCAP1. Although a conservative substitution, molecular dynamics suggests a significant change in Ca(2+)-binding to EF4 and EF2 and changes in the shape of L151F-GCAP1.
Unique attributes of cyanobacterial metabolism revealed by improved genome-scale metabolic modeling and essential gene analysis (2016)

Significance Genome-scale models of metabolism are important tools for metabolic engineering and production strain development. We present an experimentally validated and manually curated model of metabolism in Synechococcus elongatus PCC 7942 that ( i ) leads to discovery of unique metabolic characteristics, such as the importance of a truncated, linear TCA pathway, ( ii ) highlights poorly understood areas of metabolism as exemplified by knowledge gaps in nucleotide salvage, and ( iii ) accurately quantifies light input and self-shading. We now have a metabolic model that can be used as a basis for metabolic design in S. elongatus .
CMOS Position-Based Charge Qubits: Theoretical Analysis of Control and Entanglement (2019)

In this study, a formal definition, robustness analysis and discussion on the control of a position-based semiconductor charge qubit are presented. Such a qubit can be realized in a chain of coupled quantum dots, forming a register of charge-coupled transistor-like devices, and is intended for CMOS implementation in scalable quantum computers. We discuss the construction and operation of this qubit, its Bloch sphere, and relation with maximally localized Wannier functions which define its position-based nature. We then demonstrate how to build a tight-binding model of single and multiple interacting qubits from first principles of the Schrödinger formalism. We provide all required formulae to calculate the maximally localized functions and the entries of the Hamiltonian matrix in the presence of interaction between qubits. We use three illustrative examples to demonstrate the electrostatic interaction of electrons and discuss how to build a model for many-electron (qubit) system. To conclude this study, we show that charge qubits can be entangled through electrostatic interaction.
Genome-wide association study identifies 74 loci associated with educational attainment (2016)

Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals1. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our earlier discovery sample1, 2 of 101, 069 individuals to 293, 723 individuals, and a replication study in an independent sample of 111, 349 individuals from the UK Biobank. We identify 74 genome-wide significant loci associated with the number of years of schooling completed. Single-nucleotide polymorphisms associated with educational attainment are disproportionately found in genomic regions regulating gene expression in the fetal brain. Candidate genes are preferentially expressed in neural tissue, especially during the prenatal period, and enriched for biological pathways involved in neural development. Our findings demonstrate that, even for a behavioural phenotype that is mostly environmentally determined, a well-powered GWAS identifies replicable associated genetic variants that suggest biologically relevant pathways. Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases.
A Grounded Theory Investigation of Adaptations to Adverse Childhood Experiences (2018)

Adverse childhood experiences (ACEs) include childhood sexual abuse, physical abuse, emotional abuse, physical neglect, emotional neglect, and household dysfunction. Much has been reported about the detrimental outcomes associated with these experiences. The associated negative outcomes of ACEs can include addiction, suicide, disability, teenage pregnancy, and early death. However, it is well known that many people experience ACEs and do very well. Rather than viewing negative outcomes only as symptoms of trauma and positive outcomes only as signs of resilience, it is possible to consider adaptations. This study focused on how adults adapted to their adverse childhood experiences. Data were collected based on semistructured interviews with nine members of the ACEs Connection Social Network, an online support group. The data were analyzed using a constructivist grounded theory methodology. A grounded theory then emerged from data, supporting the adaptation construct.
Invasion of Porcine Brain Microvascular Endothelial Cells by Streptococcus suis Serotype 2 (2004)

Streptococcus suis is an important swine pathogen that mainly causes meningitis and occasionally causes other infections, such as endocarditis, arthritis, and pneumonia. The pathogenesis of S. suis infection has not been completely defined. However, in order to cause meningitis, S. suis has to cross the blood-brain barrier (BBB) made up of brain microvascular endothelial cells. The objective of this work was to study the interactions of S. suis serotype 2 with porcine brain microvascular endothelial cells (PBMEC). The ability of North American and European S. suis serotype 2 strains to adhere to PBMEC and, most importantly, to invade PBMEC was demonstrated by using an antibiotic protection assay and was confirmed by electron microscopy. The polysaccharide capsule of S. suis seemed to partially interfere with the adhesion and invasion abilities of the bacterium. Our results showed that intracellular viable S. suis could be found in PBMEC up to 7 h after antibiotic treatment. Inhibition studies demonstrated that invasion of PBMEC by S. suis required actin microfilaments but not microtubular cytoskeletal elements or active bacterial RNA or protein synthesis. At high bacterial doses, suilysin-positive strains were toxic for PBMEC. The role of suilysin in cytotoxicity was confirmed by using purified suilysin, electron microscopy, and the lack of toxicity of a suilysin-negative mutant. In swine, the invasion of endothelial cells of the BBB could play an important role in the pathogenesis of the meningitis caused by S. suis.