gebhart/patrepeval huggingface dataset:
Adiabatic Effectiveness, Thermal Fields, and Velocity Fields for Film Cooling With Large Angle Injection (1995)

The film cooling performance and velocity field were investigated for discrete round holes inclined at an injection angle of 55°. Results are compared to typical round film cooling holes, with an injection angle of 35°. All experiments in this study were performed at a density ratio of DR = 1.6, using cryogenic cooling of the injected air. Centerline and lateral distributions of effectiveness, were obtained for a range of momentum flux ratios. Thermal field and two component mean velocity and turbulence intensity measurements were made at a momentum flux ratio which was within the range of maximum spatially averaged effectiveness. Compared to round holes with 35° injection angle, the 55° holes showed only a slight degradation in centerline effectiveness for low momentum flux ratios, while a significant reduction in effectiveness was seen at high momentum flux ratios. The thermal field for the 55° round holes indicated a faster decay of cooling capacity for the 55° round holes. The high turbulence levels for the 55° round hole coincided with the sharp velocity gradients between the jet and freestream, and the decay of turbulence levels with downstream distance was found to be similar to those for a 35° hole.
Label-Free Cytotoxicity Screening Assay by Digital Holographic Microscopy (2012)

We introduce a label-free technology based on digital holographic microscopy (DHM) with applicability for screening by imaging, and we demonstrate its capability for cytotoxicity assessment using mammalian living cells. For this first high content screening compatible application, we automatized a digital holographic microscope for image acquisition of cells using commercially available 96-well plates. Data generated through both label-free DHM imaging and fluorescence-based methods were in good agreement for cell viability identification and a Z'-factor close to 0.9 was determined, validating the robustness of DHM assay for phenotypic screening. Further, an excellent correlation was obtained between experimental cytotoxicity dose-response curves and known IC50 values for different toxic compounds. For comparable results, DHM has the major advantages of being label free and close to an order of magnitude faster than automated standard fluorescence microscopy.
Dissolution Kinetics and Polarization of Iron Whiskers (1965)

The dissolution kinetics of iron filamentary single crystals were found to obey a mechanistic analysis based on the terrace-ledge-kink surface model. At low undersaturations, dissolution-ledge propagation from edge sites of finite crystals controlled the process and the dissolution rate was found to be a linear function of the ferrous ion concentration in solution. Generation of ledges from spiral or screw dislocation sources was rate-controlling at moderate undersaturations, the rate being dependent upon the logarithm of the under saturation ratio. A linear relationship was again followed at high undersaturations because the spacing of ledges emitted from spiral sources was small, which dictated evolution to a limiting linear case. An anodic polarization curve for the dissolution of iron whiskers in 1 N sulfuric acid, obtained by varying potassium persulfate depolarizer additions in solution, agreed favorably with the literature. The Tafel curve in the active range bifurcated with increasing current density and showed a greater rate of dissolution perpendicular to {110} surfaces. As the dissolution rate was shown to depend on the logarithm of the interfacial free energy, the orientation-dependent dissolution phenomena were in accord with the mechanistic model for surface anisotropy, especially with respect to ledge-kink configurations.
Know the Flow: Non-Contact Magnetic Flow Rate Sensing for Water Meters (2020)

Positive displacement water meters are found throughout the world's water distribution networks to totalize water consumption. Containing internal permanent magnets, the water meters are underutilized sensors. Flow data from these meter locations can be used to non-intrusively identify the operation of individual water loads from an aggregate data stream at the meter. This article models these meters as nonideal magnetic encoders and presents a methodology for inexpensively retrofitting these meters with digital flow rate measurement capabilities, effectively bringing them into the growing body of smart metering devices and non-intrusive load monitoring without any contact with the water passing through them. We present a model of the magnetic field produced by these meters, discuss associated magnetic sensing hardware, and describe compensation, flow rate estimation, and post-processing algorithms for flow rate extraction. Verification is provided with experimental results.
N-Acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTN-Acyl-L-tryptophan benzyl esters: potent substance P receptor antagonistsAngus M. MacLeod, Kevin J. Merchant, Margaret A. Cascieri, Sharon Sadowski, Elzbieta Ber, Christopher J. Swain, and Raymond BakerCite this: J. Med. Chem. 1993, 36, 14, 2044–2045Publication Date (Print):July 1, 1993Publication History Published online1 May 2002Published inissue 1 July 1993https://pubs.acs.org/doi/10.1021/jm00066a015https://doi.org/10.1021/jm00066a015research-articleACS PublicationsRequest reuse permissionsArticle Views228Altmetric-Citations66LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis and Electronic Properties of Semiconducting Polymers Containing Benzodithiophene with Alkyl Phenylethynyl Substituents (2010)

Semiconducting polymers containing benzodithiophene with decyl phenylethynyl and hexadecyl phenylethynyl substituents have been synthesized by Stille coupling polymerization. The optoelectronic properties of the synthesized polymers have been investigated. The synthesized polymers were tested in bulk heterojunction solar cells.
Electrical and Optical Modeling of Electrode Configuration for Optimal Dust Removal in Electrodynamic Screens (EDS) (2019)

The electrodynamic screen (EDS) has been proposed as a method for mitigating energy yield loss due to natural soiling on the optical surface of photovoltaic modules. The objective of this work is to optimize EDS electrode geometry in order to maximize dust removal while maintaining an acceptable degree of optical transmission efficiency. This will provide the foundation for future research in specifying design variations for various geographical locations, where the nature of soiling may vary.
DiverseVacAAllelic Types ofHelicobacter pyloriin Korea and Clinical Correlation (2002)

Helicobacter pylori has a diversity of vacA allelic types. The purpose of this study was to correlate the vacA status and the clinical outcome. After constructing specific primers for the vacA signal sequence, H. pylori-positive antral biopsy specimens were examined for the vacA status in 25 gastric ulcers, 31 duodenal ulcers, 22 gastric cancers, 42 chronic gastritis, and 8 gastroduodenal ulcers. The relationship between the vacA allele and the clinical disease was examined. The vacA genotype s1c/m1 is predominant in Korea (71/128, 55.5%). Other strains including s1b or s2 were not found in this study. s1c/m1 was more prominent in duodenal ulcers, than in gastric ulcers (p=0.041) and cancer (p=0.029). Seven out of 8 patients with gastric and coexistent duodenal ulcers had the s1c/m1 allele. No statistical differences in the positive rates of the s1a/m1, s1a/m2, and s1c/m2 alleles among the disease groups were found. In conclusion, s1c/m1 is the main vacA allele in Korea and it is particularly associated with duodenal ulcers.
ChemInform Abstract: METHODOLOGIES FOR 2‐ALKYLIDENE‐1,3‐CYCLOPENTANEDIONES (1984)

Abstract Die Synthese von 2‐Alkyliden‐l ,3‐cyclopentandionen (VI) und (XI) sowie ihr chemisches Verhalten werden beschrieben.
116 Autologous and Heterologous Neutralizing Antibody Responses in HIV-1 Infection (2012)

We have been studying the magnitude, breadth, kinetics and epitope specificity of the neutralizing antibody (nAb) response in early and chronic HIV-1 infection. The earliest nAb response was highly specific for the early autologous virus but within 1–2 years of infection, low titers of broadly neutralizing activity were detected in a subset of subjects. High titers of broadly neutralizing activity were detected in ∼15% of chronically infected individuals (outstanding neutralizers). The earliest autologous nAb response in two HIV-1 subtype B-infected individuals targeted a novel 332-glycan-dependent epitope in a 4-stranded antiparallel sheet immediately below the base of the V3-loop, near the coreceptor binding domain of gp120. This same glycan was required for the heterologous neutralizing activity of serum samples from 3/9 of the most outstanding neutralizers in our chronic infection cohort. Additional broadly neutralizing epitopes were targeted by these 9 subjects, including MPER (3 subjects), PG9/16-like (2 subjects) and CD4bs (1 subject). Some broadly neutralizing activity could not be mapped with current technologies. Serum from a subset of outstanding neutralizers targeted multiple conserved nAb epitopes, including one subject who made both PG9-like and VRC01-like nAbs, providing proof-of-concept for polyvalent vaccine immunogens. Serum samples from 6 outstanding neutralizers examined were capable of neutralizing multiple variants in the contemporaneous viral quasispecies, suggesting that escape from broadly nAbs is limited by fitness constraints. This collective information is useful for identifying new mAbs, delineating the ontogeny of broadly nAb responses and designing novel vaccine immunogens.
Automation Etiquette in the Augmented Cognition Context (2005)

Neurophysiologically triggered adaptive assistance offers many advantages over traditional approaches to automation. These systems offer the promise of leveraging the strengths of humans and machines-- augmenting human performance with automation specifically when human abilities fall short of the demands imposed by task environments. However, by delegating critical aspects of complex tasks to autonomous automation components, these systems run the risk of introducing many of the problems observed in traditional human-automation interaction contexts. This paper describes steps taken to mitigate the possibility of introducing these problems in the context of an augmented cognition system to help dismounted soldiers perform taxing cognitive tasks. It describes specific design decisions that address many of the concerns raised by automation researchers, and presents a summary of performance results that support the overall efficacy of implemented measures.
Supplementary Table 1 from Antibody-Drug Conjugates for the Treatment of Non–Hodgkin's Lymphoma: Target and Linker-Drug Selection (2023)

Supplementary Table 1 from Antibody-Drug Conjugates for the Treatment of Non–Hodgkin's Lymphoma: Target and Linker-Drug Selection
Molecular Bonding Technology - an Innovative Manufacture Technology in the 21st Century (2016)

We have developed a molecular bonding technology that forms a layer of molecules on the surface of the adherends and provides a smooth surface with strong joining force for the manufacturing of structures composed of different materials. We have applied this technology to the process of direct copper plating on a polyimide film with a smooth surface in order to manufacture flexible printed circuits (FPCs) with high performance.
Effects of NSAIDs on Bladder Function in Normal and Cystitis Rats: a Comparison Study of Aspirin, Indomethacin, and Ketoprofen (2004)

To clarify the potential usefulness of non-steroidal anti-inflammatory drugs, NSAIDs, for patients with overactive bladder, we examined the effect of NSAIDs on urodynamic parameters in normal and cystitis rats and compared their ulcerogenic activity in the gastrointestinal mucosa. Cystometry was performed after administration of the conventional NSAIDs, aspirin, indomethacin, or ketoprofen. Prostaglandin levels were measured in the bladder of cystitis rats pretreated with NSAIDs. Furthermore, the ulcerogenic responses were examined. NSAIDs increased bladder capacity without any effect on micturition pressure in normal rats in the following rank order of potency: ketoprofen > or = indomethacin > or = aspirin. In cystitis rats, bladder capacity was increased and micturition frequency was decreased. The levels of prostaglandin were significantly increased in cystitis rats. All NSAIDs inhibited the increment of prostaglandin levels at doses equal to that effective in the improvement of bladder functions. When administered intraduodenally, both ketoprofen and indomethacin induced lesions in the gastrointestinal mucosa. However, aspirin had no significant effect. We demonstrate that NSAIDs are effective in animal models of disease, most likely by suppressing by prostaglandin synthesis. Since aspirin, in contrast to ketoprofen or indomethacin, did not cause any gastrointestinal lesions, aspirin might be the NSAIDs treatment of choice for overactive bladder.
Data from Oligodendrocyte Progenitor Cells Promote Neovascularization in Glioma by Disrupting the Blood–Brain Barrier (2023)

&lt;div&gt;Abstract&lt;p&gt;Enhanced platelet-derived growth factor (PDGF) signaling in glioma drives its development and progression. In this study, we define a unique role for stroma-derived PDGF signaling in maintaining tumor homeostasis within the glioma microenvironment. Large numbers of PDGF receptor-α (PDGFRα)–expressing stromal cells derived from oligodendrocytes progenitor cells (OPC) were discovered at the invasive front of high-grade gliomas, in which they exhibited a unique perivascular distribution. In PDGFRα-deficient host mice, in which orthotopic Gl261 tumors displayed reduced outgrowth, we found that tumor-associated blood vessels displayed smaller lumens and normalized vascular morphology, with tumors in host animals injected with the vascular imaging agent gadolinium also being enhanced less avidly by MRI. Notably, glioma-associated OPC promoted endothelial sprouting and tubule formation, in part by abrogating the inhibitory effect that perivascular astrocytes exert on vascular endothelial conjunctions. Stromal-derived PDGF-CC was crucial for the recruitment and activation of OPC, insofar as mice genetically deficient in PDGF-CC phenocopied the glioma/vascular defects observed in PDGFRα-deficient mice. Clinically, we showed that higher levels of PDGF-CC in glioma specimens were associated with more rapid disease recurrence and poorer overall survival. Our findings define a PDGFRα/PDGF-CC signaling axis within the glioma stromal microenvironment that contributes to vascular remodeling and aberrant tumor angiogenesis in the brain. &lt;i&gt;Cancer Res; 74(4); 1011–21. ©2013 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Identification of Distinct Prognostic Groups: Implications for Patient Selection to Targeted Therapies Among Anti-Endocrine Therapy–Resistant Early Breast Cancers (2019)

We show that aberrations of genes in these pathways are independently linked to a higher risk of relapse after endocrine treatment. Improvement of the clinical management of early breast cancers could be made by identifying those for whom current endocrine therapies are sufficient, thus reducing unnecessary treatment, and secondly, by identifying those who are at high risk for recurrence and linking molecular features that drive these cancers to treatment with targeted therapies.
The Requirements for a Computerised Database to Assist in the Efficient Management of Buildings in Use: A Healthcare Case Study (1996)

ERES:conference
Molecule Evoluator CIDRUX BV, Park Oosterspaarn 6, 2036 MB Haarlem, The Netherlands. www. cidrux.com. See Web site for pricing information. (2007)

ADVERTISEMENT RETURN TO ISSUEPREVComputer Software Re...Computer Software ReviewMolecule Evoluator CIDRUX BV, Park Oosterspaarn 6, 2036 MB Haarlem, The Netherlands. www. cidrux.com. See Web site for pricing information.Jeff ZablockiView Author Information CV TherapeuticsCite this: J. Am. Chem. Soc. 2007, 129, 41, 12586Publication Date (Web):September 20, 2007Publication History Published online20 September 2007Published inissue 1 October 2007https://pubs.acs.org/doi/10.1021/ja0769604https://doi.org/10.1021/ja0769604product-reviewACS PublicationsCopyright © 2007 American Chemical SocietyRequest reuse permissionsArticle Views101Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chemical structure,Molecular structure,Molecules,Scaffolds Get e-Alerts
Redefining the Role of Functional Testing (2006)

In this paper, we propose a new role for functional testing. We show that it can be used to optimize test sets in terms of test time and automated test equipment (ATE) memory resources, or to increase coverage. We also propose to ease the generation of functional test patterns, by reusing data sequences initially generated with system-level tools for validation purposes
Becker muscular dystrophy recombinant DNA studies in identical twins (1988)

Two identical twins with Becker Muscular Dystrophy are reported. Both twins had the same red cell types for ABO, Rh, CDE, MNSs, Kelly, Lewis, Duffy, and Kidd. HLA typing detected the same antigens in both twins: A1, A26, B8, B17, DR3, DR7. Family history was negative. The twin patients showed identical haplotypes that were different from the haplotypes of the normal male members of the family. The sister of the twins showed a recombinant X chromosome. The informative haplotype with respect to the gene of BMD, present in the twins, was ascertained in their mother as well. Our findings strongly suggest that a mutation has occurred either in the mother or in the twins.
ChemInform Abstract: A SUBSTITUENT CONSTANT ANALYSIS OF THE INTERACTION OF SUBSTITUTED NAPHTHALENE MONOIMIDES WITH DNA (1985)

Abstract Die auf den im Formelschema beschriebenen Wegen dargestellten Verbindungen (III) werden auf Antitumor‐Wirkung untersucht.
An NMR Phased Array for Human Cardiac 31P Spectroscopy (1992)

A four-coil phased-array 31P NMR receiver was designed and tested for human cardiac applications, to determine whether the combination of relatively high signal-to-noise ratio (SNR) and large field of view produced in 1H imaging is also realized for in vivo 31P spectroscopy. Spectra were acquired in parallel from an array of four overlapping 6.5-cm surface coils using one- and two-dimensional phase-encoding pulse sequences and were optimally combined to yield composite spectroscopic images. The phased array was found to generate useful 31P spectra from a 2.5-fold wider lateral region around the anterior myocardium than a single receiver of the same size as the array elements, with no increase in imaging time. In addition, the sensitive depth was increased by up to 2 cm over that of a single coil. Spectra could be acquired in roughly 15 min from a region extending to the middle of the heart, with voxel sizes of 2 x 2 x 4 cm3. For the average heart voxel, the SNR of the combined spectrum was higher than that of the best spectrum from any one coil in the array by 30%, with some voxels showing an increase as high as 60%.
Discrimination of constructed air samples using multivariate analysis of full scan membrane introduction mass spectrometry (MIMS) data (2017)

Chemometric techniques have been evaluated using full scan MIMS spectra with a series of VOC mixtures of known composition containing known compounds, and successfully applied to samples with known sources, but unknown molecular composition. These techniques have application to source identification and apportionment in real-world environmental samples impacted by atmospheric pollutants.
Compact electro-optic modulator for direct integration into an X-band antenna array front-end (2010)

A compact electro-optic modulator comprising a waveguide grating formed on a small piece of lithium niobate can be integrated directly into an X-band antenna array element. A prototype link with this modulator was demonstrated.
Synthesis of an Oxathiolane Drug Substance Intermediate Guided by Constraint Driven Innovation (2020)

A new route was developed for construction of the oxathiolane intermediate used in the synthesis of lamivudine (3TC) and emtricitabine (FTC). We developed the presented route by constraining ourselves to low cost, widely available starting materials – we refer to this as supply centered synthesis. Sulfenyl chloride chemistry was used to construct the framework for the oxathiolane from acyclic precurors. This bond construction choice enabled the use of chloroacetic acid, vinyl acetate, sodium thiosulfate and water to produce the oxathiolane.
The immune correlates of protection for an avian influenza H5N1 vaccine in the ferret model using oil-in-water adjuvants (2017)

Because of the pathogenicity and low incidence of avian influenza virus infections in humans, the immune correlates of protection for avian influenza vaccines cannot be determined from clinical studies. Here, we used the ferret model to address this for an avian influenza H5N1 vaccine. Using oil-in-water adjuvants, we generated groups of ferrets with undetectable (geometric mean titer [GMT] < 10), low (GMT = 28.3), or high (GMT > 761.1) hemagglutination-inhibition (HAI) titers to the A/Viet Nam/1203/2004 (H5N1) virus. Ferrets were then challenged with the wild-type virus and disease severity and immunologic parameters were studied. The severity of infection and symptom profile were inversely associated with pre-challenge HAI titers in a dose-dependent manner. A vaccinated ferret with no detectable HAI-antibodies but high flu-specific IgG-antibody titers mounted rapid functional antibodies after infection and experienced milder disease compared to other ferrets in the group. Compared to naïve ferrets, all vaccinated ferrets showed improved cellular immunity in the lungs and peripheral blood. High number of IFNγ<sup>+</sup> CD8- T cells in the airways was associated with early viral clearance. Thus, while neutralizing antibodies are the best correlate of protection, non-neutralizing antibodies can also be protective. This should be taken into consideration in future avian influenza vaccine trials.