gebhart/patrepeval huggingface dataset:
Ultrafast 1  MHz vacuum-ultraviolet source via highly cascaded harmonic generation in negative-curvature hollow-core fibers (2020)

Vacuum-ultraviolet (VUV) light is critical for the study of molecules and materials, but the generation of femtosecond pulses in the VUV region at high repetition rates has proven difficult. Here we demonstrate the efficient generation of VUV light at megahertz repetition rates using highly cascaded four-wave mixing processes in a negative-curvature hollow-core fiber. Both even- and odd-order harmonics are generated up to the 15th harmonic (69 nm, 18.0 eV), with high energy resolution of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow class="MJX-TeXAtom-ORD"><mml:mo>∼</mml:mo></mml:mrow><mml:mrow class="MJX-TeXAtom-ORD"><mml:mrow class="MJX-TeXAtom-ORD"><mml:mn>40</mml:mn></mml:mrow></mml:mrow><mml:mspace width="thickmathspace"/><mml:mrow class="MJX-TeXAtom-ORD"><mml:mrow class="MJX-TeXAtom-ORD"><mml:mi mathvariant="normal">m</mml:mi><mml:mi mathvariant="normal">e</mml:mi><mml:mi mathvariant="normal">V</mml:mi></mml:mrow></mml:mrow></mml:math> . In contrast to direct high harmonic generation, this highly cascaded harmonic generation process requires lower peak intensity and therefore can operate at higher repetition rates, driven by a robust <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow class="MJX-TeXAtom-ORD"><mml:mo>∼</mml:mo></mml:mrow><mml:mrow class="MJX-TeXAtom-ORD"><mml:mrow class="MJX-TeXAtom-ORD"><mml:mn>10</mml:mn></mml:mrow></mml:mrow><mml:mspace width="thickmathspace"/><mml:mrow class="MJX-TeXAtom-ORD"><mml:mrow class="MJX-TeXAtom-ORD"><mml:mi mathvariant="normal">W</mml:mi></mml:mrow></mml:mrow></mml:math> fiber-laser system in a compact setup. Additionally, we present numerical simulations that explore the fundamental capabilities and spatiotemporal dynamics of highly cascaded harmonic generation. This VUV source can enhance the capabilities of spectroscopies of molecular and quantum materials, such as photoionization mass spectrometry and time-, angle-, and spin-resolved photoemission.
SERVICE CREATION FOR RE-NORMALISING ESSENTIAL BUSINESS ENVIRONMENT: A PREVENTION BASED DIGITAL TECH APPROACH (2021)

Abstract This research investigates service creation in/after effect of coronavirus pandemic targeting the essential business environment. It follows prevention through design approach to facilitate business owners to maintain their business environments at low COVID contraction risks, for both customers and staff. The effectiveness of recommended prevention practices (like social distancing and hand-sanitising) is uncertain at public workplaces, simply due to inevitable workers and customers interactions. Such uncertainty, especially in cases of retail stores and hospitals, raises a need for the design of services and support systems for common/necessary public business activities to reduce the burden on people involved. This research investigates the risk-related metrics to realise such digital services, focussing on three types: congestion at the work environment, disinfection of store area/objects, and sanitisation of people and staffs involved. Based on this, a digital technology-based service COVSAFE was created and tested through a proof-of-concept implementation for a supermarket business environment. This implementation and its evaluations highlight the bottlenecks/challenges for realising this system in everyday scenarios.
Expression of interfacial Seebeck coefficient through grain boundary engineering with multi-layer graphene nanoplatelets (2020)

Expression of energy filtering to boost thermoelectric performance through grain boundary engineering utilising graphene.
Control-Oriented Physics-Based NOx Emission Model for a Diesel Engine With Exhaust Gas Recirculation (2019)

Abstract Publisher’s Note: This paper was selected for publication in ASME Letters in Dynamic Systems and Control. https://www.asmedigitalcollection.asme.org/lettersdynsys/article/doi/10.1115/1.4046450/1074858/Control-Oriented-Physics-Based-NOX-Emission-Model
Synchronization Monitoring of I/Q Data and Pulse Carving Misalignment for a Parallel-Type RZ-DQPSK Transmitter by Measuring RF Clock Tone/Low Frequency Power (2008)

We experimentally demonstrate a technique for monitoring the time misalignment of in-phase/quadrature (I/Q) data streams and pulse carver/data in a 20-Gb/s return-to-zero differential quadrature phase-shift-keying (RZ-DQPSK) transmitter. By measuring the radio-frequency clock-tone power at 10 GHz and low frequency power at 600 MHz, a monitoring power dynamic range of 18 dB is obtained for I/Q data misalignment and 6 dB is shown for carver/data misalignment. With the monitor information, a simple feedback loop is proposed to automatically align the RZ-DQPSK transmitter.
Phytochemical analysis of Petrosimonia sibirica grown in Kazakhstan (2018)

In this study, complete phytochemical analyses of the component composition of Petrosimonia sibirica was conducted for the first time. Phytochemical screening showed the presence of a variety of primary and secondary metabolites. The data for quantitative determination of biologically active compounds were presented. The qualitative composition of amino, fatty acids of the plant Petrosimonia sibirica has been studied by using the method of paper chromatography (PC) and thin-layer chromatography (TLC), their quantitative composition of amino, fatty acids have been identified by gas chromatography. The composition of 20 amino, 8 fatty acids of Petrosimonia sibirica, family Chenopodiaceae have been established. The major amino acids in studied plant were glutamic acid (2.440%), alanine (0.618%), aspartic acid (1.254%), arginine (0.405%), tyrosine (0.340%), and proline (0.306%). The dominant fatty acids in plant with respect to quantity were oleic (48.3%) and linoleic (26.7%) acids. In order to optimize the extraction process technological parameters (extracting solvent, a ratio between solvent and solid plant material and process temperature) were selected. The most suitable solvent is 70% ethyl alcohol, solid – solvent ratio (1: 6-8), extraction time (3 days), and extraction temperature (20-25 oC). In addition, Kazakh species of Petrosimonia sibirica plant are valued as a rich source of saponins and flavonoids. Quercetin 3-O-β-D-glucopyranoside (isoquercitrin) was isolated from Petrosimonia sibirica. Flavonoid glycoside was identified by 1H NMR, 13C NMR, and MS, and compared with the data in the literature. The results revealed the presence of medicinally important constituents in the studied plant. Therefore, extracts from these plants could be seen as a good source for useful drugs.
Improving Radio Frequency Transmission Properties of Graphene via Carrier Concentration Control toward High Frequency Transmission Line Applications (2019)

Abstract Graphene has been gradually studied as a high‐frequency transmission line material owing to high carrier mobility with frequency independence up to a few THz. However, the graphene‐based transmission lines have poor conductivity due to their low carrier concentration. Here, it is observed that the radio frequency (RF) transmission performance could be severely hampered by the defect‐induced scattering, even though the carrier concentration is increased. As a possible solution, the deposition of the amorphous carbon on the graphene is studied in the high‐frequency region up to 110 GHz. The DC resistance is reduced by as much as 60%, and the RF transmission property is also enhanced by 3 dB. Also, the amorphous carbon covered graphene shows stable performance under a harsh environment. These results prove that the carrier concentration control is an effective and a facile method to improve the transmission performance of graphene. It opens up the possibilities of using graphene as interconnects in the ultrahigh‐frequency region.
Incremental Testing Design on Slide Board for Speed Skaters: Comparison Between Two Different Protocols (2016)

Piucco, T, O'Connell, J, Stefanyshyn, D, and de Lucas, RD. Incremental testing design on slide board for speed skaters: comparison between two different protocols. J Strength Cond Res 30(11): 3116-3121, 2016-The aim of this study was to investigate the effect of stage duration (Long-stage-LS: 3-minute, Short-stage-SS: 1-minute) on maximal and submaximal aerobic physiological variables during a simulated skating test performed on a slide board. Ten well-trained male speed skaters performed 2 maximal incremental tests on slide board until voluntary exhaustion. The second ventilatory threshold (VT2) was determined by the ventilatory equivalent method. All participants reached the criteria for maximal oxygen uptake (V[Combining Dot Above]O2max) attainment in both protocols. Maximal cadence (CADmax), V[Combining Dot Above]O2 at VT2 and cadence at VT2 (CADVT2) were significantly higher during SS protocol, but maximal heart rate was significantly lower for the SS protocol. V[Combining Dot Above]O2max was significantly correlated with CADmax for the SS (r = 0.62) and LS protocols (r = 0.61). Strong correlations were found between CADmax and CADVT2 during the SS (r = 0.83) and LS protocols (r = 0.76). The results of the present study suggest that either SS or LS slide board incremental protocol can be used to evaluate skaters, since they elicited maximal physiological responses. Additionally, slide board incremental skating tests may be considered as a more specific and practical alternative than laboratory-based tests, especially when a large number of athletes need to be assessed.
Quality Assessment for Adaptive Virtual Reality Video Streaming: A Probabilistic Approach on the User’s Gaze (2019)

Accurately estimating the users’ perception of adaptive tile-based Virtual Reality (VR) video streaming is fundamental and is often used to determine subsequent streaming decisions. This is due to the fact that adaptive tile-based VR video streaming solutions aim to optimize the bandwidth usage by only streaming the areas (tiles) within the field of view of the user (viewport) at the highest quality, while keeping the remainder of the 360° environment at low quality levels. Thus, understanding the quality perceived by the user in real-time determines the success of the service. Current quality assessment approaches tend to map the quality of the viewport’s center (center tile) to the overall perceived quality. However, while such models enable to measure how long the user spend on each quality layer, they ignore the fact that the user’s eyes also move within the viewport. In this paper, we present a novel video quality assessment metric for adaptive tile-based VR video streaming which takes into account the distribution of eye movement within the viewport, as well as, the tiling scheme. Both elements are combined by means of a probability distribution fit from real users data. The model was evaluated in a well-known VR database and using an emulation environment, benchmarking it against state-of-the-art solutions as well as objective full reference metrics.
Use of Gibberellic Acid for Management of Bunch Rot on Chardonnay and Vignoles Grape (2010)

Harvest bunch rot of wine grape, caused primarily by Botrytis cinerea, is a perennial problem limiting the productivity of eastern vineyards, especially on cultivars with compact clusters. The aim of the present study was to evaluate the effectiveness of gibberellic acid (GA) sprays at reducing the compactness of Chardonnay and Vignoles clusters and minimizing bunch rot. Applications of GA reduced the number of berries per centimeter and the incidence and severity of bunch rots in Vignoles and, to a lesser extent, in Chardonnay over three consecutive years; however, the magnitude of GA effects often depended on the timing and rate of application. Bloom GA applications were more effective (P < 0.001) at reducing compactness and bunch rots than prebloom applications. Significantly, negative effects of GA applications on yield were negligible based on data from 4 years of trials on single vines and 2 years of data on 24-vine plots of Vignoles, provided the rates did not exceed 25 ppm. Regression analysis showed that berries per centimeter accounted for between 89 and 94% of variation in the incidence of Botrytis rot on Vignoles. On Chardonnay, compactness accounted for 53% of the variation in incidence, and the estimated compactness level at which no bunch rot would occur was 4.40 ± 1.05 (mean ± standard error) berries per centimeter. The relationship between cluster compactness and spray coverage of berries was also investigated in two separate experiments. Spray coverage of individual berries decreased linearly as cluster compactness increased within the range tested (3 to 18 berries per centimeter). Cluster compactness accounted for two-thirds of the variation in individual berry coverage, and coverage was reduced by 40 to 50% for clusters with about 18 berries per centimeter. These results strongly support the use of GA in integrated management of bunch rot on Vignoles and Chardonnay in eastern U.S. vineyards.
A transgenic mouse model of the slow‐channel syndrome (1996)

To investigate the effect of acetylcholine receptor (AChR) mutations on neuromuscular transmission and to develop a model for the human neuromuscular disease, the slow-channel syndrome, we generated transgenic mice with abnormal AChRs using a δ subunit with a mutation in the ion channel domain. In three transgenic lines, nerve-evoked end-plate currents and spontaneous miniature end-plate currents (MEPCs) had prolonged decay phases and MEPC amplitudes were reduced by 33%. Single nerve stimuli elicited repetitive compound muscle action potentials in vivo. Transgenic mice were abnormally sensitive to the neuromuscular blocker, curare. These observations demonstrate that we can predictably alter AChR function, synaptic responses, and muscle fiber excitation in vivo by overexpressing subunits containing well-defined mutations. Furthermore, these data support the hypothesis that the electrophysiological findings in the neuromuscular disorder, the slow-channel syndrome, are due to mutant AChRs. © 1996 John Wiley & Sons, Inc.
Superacid cyclodehydration of ketones in the production of tricyclic antihistamines (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSuperacid cyclodehydration of ketones in the production of tricyclic antihistaminesDoris P. Schumacher, Bruce L. Murphy, Jon E. Clark, Pete Tahbaz, and Thomas A. MannCite this: J. Org. Chem. 1989, 54, 9, 2242–2244Publication Date (Print):April 28, 1989Publication History Published online1 May 2002Published inissue 28 April 1989https://pubs.acs.org/doi/10.1021/jo00270a041https://doi.org/10.1021/jo00270a041research-articleACS PublicationsRequest reuse permissionsArticle Views1624Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Interaction semantics with refusals, divergence, and destruction (2010)

Formal methods for testing the conformance of a software system to its specification are considered. The interaction semantics determines the testing capabilities, which are reduced to the observation of actions and refusals (absence of actions). The semantics is parameterized by the families of observable and unobservable refusals. The concept of destruction as a prohibited action that should be avoided in the course of interaction is introduced. The concept of safe testing, the implementation safety hypothesis, safe conformance, and generation of a complete test suite based on the specification are defined. Equivalences of traces, specifications, safety relations, and interaction semantics are examined. A specification completion is proposed that can be used to remove from the specification irrelevant (not included in the safely testable implementations) and nonconformal specification traces is proposed. The concept of total testing that detects all the errors in the implementation (rather than at least one error as is the case in complete testing) is introduced. On the basis of the analysis of dependences between errors, a method for the minimization of test suites is proposed. The problem of preserving the conformance under composition (the monotonicity of conformance) is investigated, and a monotone transformation of the specification solving this problem is proposed.
In situ generation of hydrogen peroxide by carbohydrate oxidase and cellobiose dehydrogenase for bleaching purposes (2010)

The carbohydrate oxidase from Microdochium nivale (CAOX), heterologously expressed in Aspergillus oryzae, and cellobiose dehydrogenase from Myriococcum thermophilum (MtCDH), were assessed for their ability to generate bleaching species at a pH suitable for liquid detergents. The substrate specificities of CAOX and MtCDH were analyzed on a large variety of soluble and insoluble substrates, using oxygen as an electron receptor. Even insoluble substrates like cellulose were oxidized from both CAOX and MtCDH, but only MtCDH produced H₂O₂ on cotton as the sole substrate. To enhance the amount of cello-oligosaccharides formed from cotton as substrates for CAOX and MtCDH, various cellulases were used in combination with MtCDH or CAOX, leading to a 10-fold increase in H₂O₂. As model substrates for colored stains, the degradation of pure anthocyanins and stain removal of blueberry stains by CAOX and MtCDH was examined in the absence and presence of a horseradish peroxidase. Both enzymes were able to produce an amount of H₂O₂ sufficient to decolorize the pure anthocyanins within 2 h and showed significant cleaning benefits on the stains.
Abstract 18980: N-terminal Region of Cardiac Myosin Binding Protein-C Regulates Sarcomeric and Cardiac Function (2014)

Rationale: Cardiac myosin binding protein-C (cMyBP-C) is a trans-filament protein that can bind both the thick and thin filaments and regulate contraction. Previously we showed that decreased cMyBP-C phosphorylation is directly associated with catalytic cleavage of the first 271 residues of the N-terminal (N’) and, as a consequence, contractile dysfunction. This region has been shown to be largely responsible for the actin-myosin interacting properties of cMyBP-C and was postulated to regulate sarcomere sliding velocity. However, it is unknown whether it is necessary to regulate contractile function. Hypothesis: N’-region of cMyBP-C is essential for sarcomeric and cardiac function. Methods and Results: To determine the necessity of N’-region, we generated transgenic mice (C57BL/6) expressing a truncated 110kDa cMyBP-C lacking the first 271 amino acids (Tg110). Compared to non-transgenic litter-mates (NTG), Tg110 mice demonstrate high replacement levels of native cMyBP-C (>95%). Truncated cMyBP-C localized properly to the C-zone and there were no difference in cardiac sarcomere structure between Tg110 and NTG mice. Despite normal localization and sarcomere structure, Tg110 mouse hearts displayed overt chamber dilation and depressed ejection fraction as measured by echocardiography, with little evidence of fibrosis. Cardiac permeabilized myofilament preparations demonstrate depressed maximal force generation in Tg110 compared to NTG, with unchanged Ca 2+ sensitivity and cooperativity. Interestingly, Tg110 myofilaments displayed increased rate of cross-bridge cycling, supporting the hypothesis that the N’-region is responsible for actin interaction and acts as a viscous load on myosin heads. Conclusion: We show that the N’-region of cMyBP-C is indispensable for proper cardiac function. Further, we successfully demonstrate that cMyBP-C is a regulator of cardiac contractility and specifically fulfills that role via its N’-region.
Advanced DSP for I/Q imbalance compensation in a low-IF receiver (2002)

Quadrature downconversion to a very low-IF frequency is a promising idea but it has one serious problem. Unavoidable imbalances in the analog front-end between the I- and Q-branches result in finite and usually insufficient rejection of the image frequency band which causes interference. We carry out a signal analysis of an imbalanced low-IF receiver and propose a novel baseband correction structure utilizing an adaptive interference canceller. Theoretical and simulation results are provided in order to evaluate the performance of the proposed idea. The results indicate that the I/Q imbalance can be effectively compensated during the normal operation of the receiver, even in the rapidly changing case, as long as a linear system model for the imbalance is valid.
Holistic Approach to Immune Checkpoint Inhibitor-Related Adverse Events (2022)

Immune checkpoint inhibitors (ICIs) block inhibitory molecules, such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein 1 (PD-1), or its ligand, programmed cell death protein ligand 1 (PD-L1) and enhance antitumor T-cell activity. ICIs provide clinical benefits in a percentage of patients with advanced cancers, but they are usually associated with a remarkable spectrum of immune-related adverse events (irAEs) (e.g., rash, colitis, hepatitis, pneumonitis, endocrine, cardiac and musculoskeletal dysfunctions). Particularly patients on combination therapy (e.g., anti-CTLA-4 plus anti-PD-1/PD-L1) experience some form of irAEs. Different mechanisms have been postulated to explain these adverse events. Host factors such as genotype, gut microbiome and pre-existing autoimmune disorders may affect the risk of adverse events. Fatal ICI-related irAEs are due to myocarditis, colitis or pneumonitis. irAEs usually occur within the first months after ICI initiation but can develop as early as after the first dose to years after ICI initiation. Most irAEs resolve pharmacologically, but some appear to be persistent. Glucocorticoids represent the mainstay of management of irAEs, but other immunosuppressive drugs can be used to mitigate refractory irAEs. In the absence of specific trials, several guidelines, based on data from retrospective studies and expert consensus, have been published to guide the management of ICI-related irAEs.
A Novel Pinhole-Assisted Mechanical Scanning 28-kHz Ultrasonic Device to Open the Blood-Brain Barrier (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Hao‐Li Liu, Pin‐Yuan Chen, Kuo‐Chen Wei; A Novel Pinhole‐Assisted Mechanical Scanning 28‐kHz Ultrasonic Device to Open the Blood‐Brain Barrier. AIP Conf. Proc. 12 September 2011; 1359 (1): 306–311. https://doi.org/10.1063/1.3607923 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search