gebhart/patrepeval huggingface dataset:
Biocompatible Nanocomposite Enhanced Osteogenic and Cementogenic Differentiation of Periodontal Ligament Stem Cells In Vitro for Periodontal Regeneration (2020)

Decays in the roots of teeth is prevalent in seniors as people live longer and retain more of their teeth to an old age, especially in patients with periodontal disease and gingival recession. The objectives of this study were to develop a biocompatible nanocomposite with nano-sized calcium fluoride particles (Nano-CaF<sub>2</sub>), and to investigate for the first time the effects on osteogenic and cementogenic induction of periodontal ligament stem cells (hPDLSCs) from human donors.Nano-CaF<sub>2</sub> particles with a mean particle size of 53 nm were produced via a spray-drying machine.Nano-CaF<sub>2</sub> was mingled into the composite at 0%, 10%, 15% and 20% by mass. Flexural strength (160 ± 10) MPa, elastic modulus (11.0 ± 0.5) GPa, and hardness (0.58 ± 0.03) GPa for Nano-CaF<sub>2</sub> composite exceeded those of a commercial dental composite (<i>p <</i> 0.05). Calcium (Ca) and fluoride (F) ions were released steadily from the composite. Osteogenic genes were elevated for hPDLSCs growing on 20% Nano-CaF<sub>2</sub>. Alkaline phosphatase (ALP) peaked at 14 days. Collagen type 1 (COL1), runt-related transcription factor 2 (RUNX2) and osteopontin (OPN) peaked at 21 days. Cementogenic genes were also enhanced on 20% Nano-CaF<sub>2</sub> composite, promoting cementum adherence protein (CAP), cementum protein 1 (CEMP1) and bone sialoprotein (BSP) expressions (<i>p <</i> 0.05). At 7, 14 and 21 days, the ALP activity of hPDLSCs on 20% Nano-CaF<sub>2</sub> composite was 57-fold, 78-fold, and 55-fold greater than those of control, respectively (<i>p <</i> 0.05). Bone mineral secretion by hPDLSCs on 20% Nano-CaF<sub>2</sub> composite was 2-fold that of control (<i>p <</i> 0.05). In conclusion, the novel Nano-CaF<sub>2</sub> composite was biocompatible and supported hPDLSCs. Nano-CaF<sub>2</sub> composite is promising to fill tooth root cavities and release Ca and F ions to enhance osteogenic and cementogenic induction of hPDLSCs and promote periodontium regeneration.
Supramolecular Chemistry of Anionic Cobalt(III) Bis(dicarbollide) and Cyclotriveratrylene in the Solid State and the Gas Phase (2000)

Polymer layers templated around [Co(C2B9H11)2]− (1) counter ions are one of the structural features of the two-dimensional coordination polymer obtained in crystalline form from Na-1 and cyclotriveratrylene (CTV). In solution the [Na(CTV)]1(CF3CH2OH)0.25 coordination polymer breaks up and [Nan(CTV)m]n+ clusters are present in the gas phase and can complex one or two [Co(C2B9H11)]− ions.
Thermal Degradation and Combustion Mechanism of EVA-Magnesium Hydroxide-Zinc Borate (2001)

The action of a zinc borate in copolymer ethylene-vinyl acetate / Mg(OH)2 formulations is studied. It is shown that zinc borate acts as a synergistic agent. The mode of action of the flame retardants is elucidated. The transformation of Mg(OH)2 to MgO leads in the first step to a decrease in the temperature of the substrate (endothermic effect of the decomposition of Mg(OH)2); this leads to an increase in the time to ignition of the material. In a second step, a protective MgO-based ceramic is formed. It is shown that zinc borate plays the role of a binder (formation of boron oxide) in the formation of the MgO-based ceramic. This material at the surface of the substrate act then as a physical/thermal barrier. The degradation of the polymeric matrix is slowed down and the flow of flammable molecules is reduced.
Demonstration by Confocal Microscopy that Unliganded Overexpressed Glucocorticoid Receptors are Distributed in a Nonrandom Manner throughout All Planes of the Nucleus (1991)

Mouse glucocorticoid receptors (GR) that are over-expressed in Chinese hamster ovary (CHO) cells behave like progesterone receptors, in that the unliganded receptor localizes to the nucleus where it resides in a loosely bound docking complex, probably in association with the 90-kDa heat shock protein (hsp90) and hsp70. In this paper we examine the localization of the overexpressed GR within the CHO cell nucleus by confocal microscopy. In hormone-free cells the receptor distributes in a mottled pattern throughout all planes of the nucleus. The receptor is not present in nucleoli and shows no preferential localization in the periphery vs. the center of the nucleus. The mottled distribution in each plane of the nucleus demonstrates clearly that there are regions that do not contain receptor; thus, the distribution of the GR is not random. When triamcinolone acetonide is added to the CHO cells, there is no detectable change in receptor distribution. Overexpressed receptors that have either no hormone-binding activity or no DNA-binding activity because of point mutations localize in the same mottled pattern as the wild-type receptor. These observations are consistent with the proposal that the overexpressed GR can enter the nucleus in its unliganded state and proceed to loci distributed throughout the nucleus, where it is retained in an inactive docking complex until the binding of hormone triggers its progression to high affinity sites where the primary events in transcriptional activation occur. As there is no detectable change in localization with the addition of ligand, we suggest that the docking complex may be located very near or possibly at the site where the primary events in transcriptional activation occur.
Observations of Record-Keeping in Co-located Collaborative Analysis (2013)

Record-keeping is known to facilitate visual data analysis in single user and asynchronous collaborative settings. We Implemented Co Spaces, a tool for collaborative visual data analysis with a record-keeping mechanism that enables tracking of analysis history. Then we conducted an observational study with ten pairs analyzing a sales dataset, to study how collaborators use visual record-keeping during co-located work on a tabletop. We report actions on visual record-keeping and inferred key user intentions for each action. Actions and intentions varied depending on the analytical phase and collaboration style. Based on our findings, we suggest providing various views of recorded material, showing manually saved rather than automatically saved items by default, enabling people to review collaboratorsâ work unobtrusively and automatically recommending items related to a userâs analytical task.
D21S194, a jump clone from D21S16 (1990)

Journal Article D21S194, a jump clone from D21S16 Get access A.P. Walker, A.P. Walker Search for other works by this author on: Oxford Academic PubMed Google Scholar F. Collins, F. Collins Search for other works by this author on: Oxford Academic PubMed Google Scholar T. Siddique, T. Siddique Search for other works by this author on: Oxford Academic PubMed Google Scholar L.H. Yamaoka, L.H. Yamaoka Search for other works by this author on: Oxford Academic PubMed Google Scholar M.H. Herbstreith, M.H. Herbstreith Search for other works by this author on: Oxford Academic PubMed Google Scholar M.A. Pericak-Vance, M.A. Pericak-Vance Search for other works by this author on: Oxford Academic PubMed Google Scholar S.L. Secore, S.L. Secore Search for other works by this author on: Oxford Academic PubMed Google Scholar W.-Y. Hung, W.-Y. Hung Search for other works by this author on: Oxford Academic PubMed Google Scholar A.M. Goate, A.M. Goate 2St. Mary's Hospital Medical SchoolLondon W2 1 PG, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar J.A. Hardy, J.A. Hardy 2St. Mary's Hospital Medical SchoolLondon W2 1 PG, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar ... Show more D. Patterson, D. Patterson 3Eleanor Roosevelt Institute for Cancer ResearchDenver, CO 80262, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar A.D. Roses, A.D. Roses Search for other works by this author on: Oxford Academic PubMed Google Scholar R.J. Bartlett R.J. Bartlett Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 18, Issue 7, 11 April 1990, Page 1931, https://doi.org/10.1093/nar/18.7.1931-a Published: 11 April 1990
Double-arm hexagonal archimedean spiral antenna for wideband compact array (2017)

This paper proposes a spiral antenna array for wideband compact array which is composed of an Archimedean spiral antenna with double arms. It is a low profile, hexagonal spiral antenna array which can have beam scan angle of 30 degrees without grating lobe from 1.5 GHz to 6 GHz (4:1 bandwidth). When we design the wideband array, the space of elements is limited for beam-steering. However, the limitation is solved by mutual coupling between each element. It has better performance in comparison with the previous spiral antenna array method. The array performance for beam-steering is represented by radiation patterns at the certain frequencies.
Synthesis of Substituted Benzenes and Phenols by Ring‐Closing Olefin Metathesis (2008)

New synthetic approaches to substituted aromatic compounds are reported. Ring-closing olefin metathesis (RCM)/dehydration and RCM/tautomerization are the key processes in the synthesis of substituted benzenes 3 and phenols 6, respectively. Readily accessible 1,5,7-trien-4-ols 7, which are the precursors of benzenes, were prepared from beta-halo-alpha,beta-unsaturated aldehydes 11 or beta-halo-alpha,beta-unsaturated esters 19 by utilizing reliable transformations in which cross-coupling with vinylic metal reagents 12 and allylation with allylic metal reagents 13 were employed as carbon-carbon bond forming reactions. RCM of 7, followed by dehydration, afforded a wide variety of substituted benzenes 3. In addition, RCM of 1,5,7-trien-4-ones 9, which were prepared by oxidation of 7, furnished various substituted phenols 6 by automatic tautomerization.
Filtration Behavior of Diesel Particulate Filters (1) (2007)

&lt;div class="htmlview paragraph"&gt;This paper is Part-1 of two papers discussing the filtration behavior of diesel particulate filters. Results of the fundamental study are presented in Part-1, and test results for real size DPFs are reported in the supplement, Part-2. In this paper, a fundamental experimental study was performed on the effect of pore size and pore size distribution on the PM filtration efficiency of the ceramic, wall-flow Diesel Particulate Filter (DPF). Small round plates of various average mean pore sizes (4.6, 9.4, 11.7, 17.7 micro-meters) with a narrow pore size distribution were manufactured for the tests. During the DPF filtration efficiency tests, ZnCl&lt;sub&gt;2&lt;/sub&gt; particles in the range of 10 nm to 500 nm were used instead of PM from actual diesel engine exhaust. ZnCl&lt;sub&gt;2&lt;/sub&gt; particles were made using an infrared furnace and separated into monodisperse particles by DMA (Differential Mobility Analyzer). Various ZnCl&lt;sub&gt;2&lt;/sub&gt; particle sizes were introduced upstream of the test plates and particle numbers were counted at the upstream and the downstream positions to determine filtration efficiency. In addition, theoretical calculations were made for the collection mechanisms of i) diffusion, ii) interception and iii) inertia. The theoretical calculations were compared with the experimental test results. On-engine testing of a DPF, with optimum pore size distribution, demonstrated overall filtration efficiency of &amp;gt;90% during preconditioning operation of the NEDC test cycle. The potential of the deep-bed filtration model for predicting filtration efficiency of wall-flow type ceramic DPFs was confirmed. Additional vehicle tests were performed on DPFs with various pore structures. The results are shown and discussed in the Part-2.&lt;/div&gt;
[From genomics to therapeutics]. (2000)

The sequencing of the human genome will be achieved in the first years of the next century. This program is often presented as constituting a huge hope for medicine. It is sometimes expected that a disease-free world is a realistic prospect for tomorrow. Otherwise, the future of therapeutics is viewed as characterized by a personalized medicine in which each person will be preventively or curatively treated in function of its genetic make-up, assuring a maximal efficacy and the absence of toxicity. In fact, we have to be cautious, even if, indeed, progress are expected in chemotherapy and biological therapies. Expected difficulties will arise from the nature of the main diseases persisting in the developed countries, and from the economical situation in the developing ones. Fortunately for the modern doctors, their grand-grand children will still have the possibility to become themselves doctors: patients requiring treatments will still be there!
Integrated non-III-nitride/III-nitride tandem solar cell (2011)

III-nitrides have recently been demonstrated as potential photovoltaic device material particularly in the high-energy portion of the solar spectrum. The large lattice mismatch between InN and GaN however, makes it difficult to grow good quality high In-composition InGaN films for low bandgap subcells. The integration of III-N based solar cells, which have currently been demonstrated to work well above 2.0 eV, with mature IV and III-V based solar cell technologies, which work well at bandgaps ≤ 2.0 eV, has the potential to improve the efficiency of current multi-junction solar cells. In this paper, we present the first on-wafer integration of InGaN/GaN solar cells with non-III-nitride (GaAs) solar cells.
Ventricular atriopeptin. Unmasking of messenger RNA and peptide synthesis by hypertrophy or dexamethasone. (1987)

Left ventricular hypertrophy or treatment with dexamethasone caused a 2.5-fold to threefold increase in both immunoreactive atriopeptin (AP) and AP messenger RNA (mRNA), primarily in left ventricular tissue. The combined treatments increased immunoreactive AP and AP mRNA more than either treatment alone. In the animals in which cardiac hypertrophy had been produced by abdominal aortic constriction, there was a decrease in atrial levels of AP and an increase in plasma levels of immunoreactive AP. The increase in left ventricular immunoreactive AP was confirmed by immunohistochemical staining of tissue from hypertrophied and/or dexamethasone-treated rats. The mRNA accumulated in the left ventricle was identical to atrial AP mRNA, as judged by transcriptional start site and by size on Northern blots. Because the mass of ventricular tissue is substantially greater than that of atrial tissue, the induced mRNA levels may represent a total abundance approaching one third of the total AP mRNA in the atria. High performance liquid chromatographic purification of ventricular extracts primarily demonstrated the presence of the high molecular precursor and small amounts of C-terminal peptide AP. Induction of ventricular AP (mRNA and peptide) may represent regression of the tissue to an earlier developmental form. These data provide a unique example of regulation of AP biosynthesis in nonatrial tissue.
Sexual Partner Referral for HIV Testing Through Social Networking Platforms: Cross-sectional Study (2021)

Partner-elicited interviews can effectively promote referral for HIV testing and case identification via Line, and can clarify unknown sexual affiliations of MSM to facilitate the development of a tailored prevention program. Social network analysis is needed for an insightful understanding of the different network structures.
Endothelial Foxp1 Regulates Neointimal Hyperplasia Via Matrix Metalloproteinase‐9/Cyclin Dependent Kinase Inhibitor 1B Signal Pathway (2022)

Background The endothelium is essential for maintaining vascular physiological homeostasis and the endothelial injury leads to the neointimal hyperplasia because of the excessive proliferation of vascular smooth muscle cells. Endothelial Foxp1 (forkhead box P1) has been shown to control endothelial cell (EC) proliferation and migration in vitro. However, whether EC-Foxp1 participates in neointimal formation in vivo is not clear. Our study aimed to investigate the roles and mechanisms of EC-Foxp1 in neointimal hyperplasia. Methods and Results The wire injury femoral artery neointimal hyperplasia model was performed in Foxp1 EC-specific loss-of-function and gain-of-function mice. EC-Foxp1 deletion mice displayed the increased neointimal formation through elevation of vascular smooth muscle cell proliferation and migration, and the reduction of EC proliferation hence reendothelialization after injury. In contrast, EC-Foxp1 overexpression inhibited the neointimal formation. EC-Foxp1 paracrine regulated vascular smooth muscle cell proliferation and migration via targeting matrix metalloproteinase-9. Also, EC-Foxp1 deletion impaired EC repair through reduction of EC proliferation via increasing cyclin dependent kinase inhibitor 1B expression. Delivery of cyclin dependent kinase inhibitor 1B-siRNA to ECs using RGD (Arg-Gly-Asp)-peptide magnetic nanoparticle normalized the EC-Foxp1 deletion-mediated impaired EC repair and attenuated the neointimal formation. EC-Foxp1 regulates matrix metalloproteinase-9/cyclin dependent kinase inhibitor 1B signaling pathway to control injury induced neointimal formation. Conclusions Our study reveals that targeting EC-Foxp1-matrix metalloproteinase-9/cyclin dependent kinase inhibitor 1B pathway might provide future novel therapeutic interventions for restenosis.
Interlaboratory evaluation of methods to quantify skin‐sensitizing hydroperoxides of limonene and linalool (II): Analysis in cosmetic bases (2018)

Abstract The fragrant terpenes limonene and linalool can form skin‐sensitizing hydroperoxides ( HP s) upon prolonged exposure to air. Sources of exposure of consumers to sensitizing doses of HP s have not been identified, and it is not clear whether fragranced products are a relevant source. Previously this question was addressed via analytical studies on fine fragrances; however, linalool and limonene are widely used in different consumer products, especially in other leave‐on toiletries. Hence, analytical methods also need to be able to detect potential HP s in more complex consumer product matrices. Here we applied different simple extraction methods and a toolbox of analytical methods to creams and lotions. Blinded samples of a commercial skin cream and a body lotion were spiked with four different HP s at different doses. Five laboratories analysed the samples with a method based on HP reduction in the sample, followed by Extrelut ® NT extraction and GC ‐ MS to quantify the formed alcohols. This method found an average recovery of spiked levels of 80–105%, with a relative standard deviation between laboratories of 11–25% in samples spiked with 100–200 μg g −1 . Quantification was also possible in samples spiked with 20–50 μg mL −1 , with a relative standard deviation between laboratories of 11–38%. Thus, this method can indirectly detect low levels of HP s in complex bases. In parallel, the same samples were analysed with three LC ‐based methods directly detecting the parent HP s: LC coupled with chemiluminescence, LC ‐Q‐ TOF ‐ MS , and LC ‐orbitrap‐ MS . On average, the different analytes were detected with a recovery of 80–143%. No HP s were detected in the non‐spiked products, despite the fact that they do contain linalool and limonene. Results of these studies indicate that consumer exposure can now be studied routinely in different product types as the required methods are ready for roll‐out.
Polystyrene‐Supported 2‐Arylindenyl Zirconocene Catalysts for Propylene Polymerization (2002)

Abstract Mono‐ and bis 2‐arylindenyl zirconocene/methylalumoxane (MAO) catalysts are prepared on a crosslinked polystyrene resin using gel‐phase organic reactions. The 2‐arylindene ligands are bonded to the polystyrene backbone through a disiloxane linkage, and the zirconocene is prepared directly on the support in high yield. These supported 2‐arylindenylzirconocenes in the presence of MAO show high activity and yield polypropylenes with microstructures similar to those produced by the analogous solution‐phase catalysts.
Bragg grating based Fabry-Perot filters for characterizing silicon-on-insulator waveguides (2012)

Bragg grating based Fabry-Perot filters implemented on a submicron silicon waveguide and providing sub-GHz transmission notches are used to characterize the waveguide effective index, group index and propagation loss.
Light-emitting diodes operating above unity efficiency for infrared absorption spectroscopy (2012)

Recent work has experimentally demonstrated that heated infrared light-emitting diodes can absorb lattice heat to generate photons above unity efficiency. We present new record-high conversion efficiencies and use these sources for absorption spectroscopy at 2.5μm.
Supplementary Table S1 from Transcriptomic Profiling of Sequential Tumors from Breast Cancer Patients Provides a Global View of Metastatic Expression Changes Following Endocrine Therapy (2023)

&lt;p&gt;Supplementary Table S1: List of 31 genes which are upregulated in metastatic tumours relative to matched primary tumours for all three patients&lt;/p&gt;
Enabling Longitudinal Exploratory Analysis of Clinical COVID Data (2021)

As the COVID-19 pandemic continues to impact the world, data is being gathered and analyzed to better understand the disease. Recognizing the potential for visual analytics technologies to support exploratory analysis and hypothesis generation from longitudinal clinical data, a team of collaborators worked to apply existing event sequence visual analytics technologies to a longitudinal clinical data from a cohort of 998 patients with high rates of COVID-19 infection. This paper describes the initial steps toward this goal, including: (1) the data transformation and processing work required to prepare the data for visual analysis, (2) initial findings and observations, and (3) qualitative feedback and lessons learned which highlight key features as well as limitations to address in future work.
Novel approximated zero forcing pre-coding technique with threshold for diffusion based molecular communication (2020)

This letter proposes approximated zero forcing precoding with a threshold in molecular communication (MC). Frequency domain precoding for channel equalization is investigated. Owing to the restriction of a transmitter in MC the main part of an equalized waveform is extracted and a corresponding rectangular waveform is transmitted. In the proposed equalization scheme, the frequency component of the transmit signal is suppressed if a threshold exceeds the channel coefficient in the proposed scheme. Numerical results obtained through computer simulation show that approximation by a single rectangular waveform achieves almost the same performance as that with rectangular approximation that suppresses inter-symbol interference with the proposed precoding technique.