gebhart/patrepeval huggingface dataset:
High density packaging of vertical-cavity surface-emitting laser arrays using micro-machined springs (2002)

We present a novel flip-chip packaging technology capable of interconnecting optoelectronic devices packed at very high density. The process utilizes micro-machined cantilevers for establishing electrical contact and is assembled at room temperature without solder. We have used the packaging technology to interconnect various optoelectronic devices, including 200-element arrays of independently addressable VCSELs having 4 /spl mu/m-wide pads on 6 /spl mu/m pitch to silicon CMOS driver chips with equally dense output lines.
Workshop on desktop search (2011)

The first SIGIR workshop on Desktop Search was held on 23rd July 2009 in Geneva, Switzerland. The workshop consisted of 2 industrial keynotes, 10 paper presentations in a combination of oral and poster format and several discussion sessions. This report presents an overview of the scope and contents of the workshop and outlines the major outcomes.
283. Targeted Delivery of C/EBPα-Small Activation RNA (saRNA) by RNA Aptamer Inhibits the Growth of Pancreatic Ductal Adenocarcinoma (PDAC) In Vivo (2015)

Transcriptional factor C/EBPα (CCAAT/enhancer-binding protein-a) is downregulated and silenced in pancreatic ductal adenocarcinoma (PDAC). In this study, we tested the feasibility of targeting promoter regions of transcriptional factor C/EBPα to induce transcriptional activation by small activation RNA (saRNA) for cancer therapeutics in PDAC. C/EBPα is known to up-regulate p21, a strong inhibitor of cell proliferation. C/EBPα-saRNA inhibited cell proliferation in PDAC. For the targeted delivery into cells, small structured single-stranded RNAs known as aptamers, recognizing targets specifically, were employed for the effective delivering vehicles. 2’-fluropyrimidine RNA aptamers (2’F-RNA) were selected to acquire nuclease resistance based on the whole cell SELEX. The cell internalization was evaluated through flow cytometry and confocal microscopy. The selected 2’F-RNA aptamers got internalized into a variety of pancreatic cancer cell lines. Human pancreatic cancer specimen histopathology and cell binding assays indicated that they recognized cancer cells specifically, not to normal cells. The conjugates, aptamer with C/EBPα-saRNA, were constructed for the targeted delivery. The conjugates escaped endosome and localized in nuclear. The conjugates of aptamer with C/EBPα-saRNA inhibited cell proliferation and upregulated gene expression. Xenograft mice model was used to test tumor cell growth inhibition in vivo throughout the transcriptional activation of C/EBPα. The conjugates of aptamer with C/EBPα-saRNA reduced tumor burden significantly in vivo, showing its anti-tumor effects. The aptamer target expressed on cell membrane was identified mitochondrial Hsp70. For the first time, results from these studies provide a new therapeutics strategy through transcriptional activation of C/EBPα by aptamer mediation induce anti-tumor effects in pancreatic cancer.
Location-based Initial Access for Wireless Power Transfer with Physically Large Arrays (2022)

Radio frequency (RF) wireless power transfer (WPT) is a promising technology for 6G use cases. It enables a massive yet sustainable deployment of batteryless energy neutral (EN) devices at an unprecedented scale. Recent research on 6G is exploring high operating frequencies up to the THz spectrum, where antenna arrays with large apertures are capable of forming narrow, “laser-like” beams. At sub-10 GHz frequencies, physically large antenna arrays are considered that are operating in the array near field. Transmitting spherical wavefronts, power can be focused to a focal point rather than a beam, which allows for efficient and radiation-safe WPT. We formulate a multipath channel model comprising specular components and diffuse scattering to find the WPT power budget in a realistic indoor scenario. Specular components can be predicted by means of a geometric model. This is used to transmit power via multiple beams simultaneously, increasing the available power budget and expanding the initial access distance. We show that exploiting this “beam diversity” reduces the required fading margin for the initial access to EN devices.
A multicentre randomised assessment of the DAWN AC computer-assisted oral anticoagulant dosage program (2009)

Computer-assisted oral anticoagulant dosage is being increasingly used to meet growing demands for oral anticoagulation. The DAWN AC is one of the most widely used computer-dosage programs. Evidence of its value and that of other computer programs has been based previously only on laboratory evidence of "time in target INR range" (TIR) not on clinical safety in practice. A five-year international randomised clinical study of computer assistance with the DAWN AC program compared with manual dosage in 2,631 patients has been performed at 13 centres with established expertise in oral anticoagulation mainly in the EU. Safety assessment have been based on the comparison of bleeding or thrombotic events with DAWN AC compared with manual dosage in a randomised study. Safety of the DAWN AC program has been demonstrated. Clinical events of bleeding and thrombosis were almost identical with the experienced manual dosage group. Therapeutic control improved with DAWN AC to 66.8% from 63.4% TIR. The program failed to provide a dosage recommendation on only 5.7% of occasions. At a group of experienced centres with a special interest in oral anticoagulation, the DAWN AC computer-dosage program proved as safe clinically as manual dosage by experienced medical staff. With DAWN AC, laboratory control was improved, the difference being highly significant. The results should reassure hospitals and community clinics that the DAWN AC program is safe and facilitate greater and longer provision of warfarin treatment where required.
In-system optimization of a hologram for high-stability parallel laser processing (2020)

A method for optimizing a computer-generated hologram (CGH) for high-stability laser processing is proposed. The CGH is optimized during laser processing; therefore, unpredicted dynamic changes in the laser processing system, in addition to its static imperfections, are automatically compensated for by exploiting the rewritable capability of the spatial light modulator. Consequently, the short-term and long-term stability are improved, which will contribute to the realization of high-speed, high-precision laser processing. A CGH that generated 36 parallel beams was continuously optimized, and the maximum uniformity reached 0.98, which is higher than reported in previous research. To the best of our knowledge, this is the first demonstration of gradual improvement of parallel laser processing with in-process optimization of the CGH. Furthermore, it was also demonstrated that the performance of the laser processing system against unexpected disturbances was improved.
Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis (2016)

Glioblastomas have been proposed to be maintained by highly tumorigenic glioblastoma stem cells (GSCs) that are resistant to current therapy. Therefore, targeting GSCs is critical for developing effective therapies for glioblastoma. In this study, we identify the regulatory cascade of the nuclear receptor TLX and the DNA hydroxylase Ten eleven translocation 3 (TET3) as a target for human GSCs. We show that knockdown of TLX expression inhibits human GSC tumorigenicity in mice. Treatment of human GSC-grafted mice with viral vector-delivered TLX shRNA or nanovector-delivered TLX siRNA inhibits tumour development and prolongs survival. Moreover, we identify TET3 as a potent tumour suppressor downstream of TLX to regulate the growth and self-renewal in GSCs. This study identifies the TLX-TET3 axis as a potential therapeutic target for glioblastoma.
Vertical channel devices enabled by through silicon via (TSV) technologies (2016)

Novel device structures with vertical channels gated by TSV's are demonstrated. The unique device structure is realized in a standard TSV process flow, without new material systems or processes. They can be used for both characterizing the TSV process as well as enable new functions. They can be easily integrated into product designs thus enabling field monitoring.
Compact thermal-interaction model for dynamic within chip temperature determination by circuit simulation (2012)

We report an equivalent circuit for capturing the thermal propagation from a heat source, creating thermal energy by the self-heating effect, to other devices during circuit operation. It is verified that the equivalent circuit reproduces measured transient thermal propagation characteristics for different layouts. The test structures are also applied to extract the magnitude of the elements included in the equivalent circuit.
Structure of an iron(II) complex with a novel sexadentate ligand derived from a tetraaza macrocycle (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure of an iron(II) complex with a novel sexadentate ligand derived from a tetraaza macrocycleKristin Bowman. Mertes, P. W. R. Corfield, and Daryle H. BuschCite this: Inorg. Chem. 1977, 16, 12, 3226–3230Publication Date (Print):December 1, 1977Publication History Published online1 May 2002Published inissue 1 December 1977https://doi.org/10.1021/ic50178a049RIGHTS & PERMISSIONSArticle Views69Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (596 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Some Properties of Influenza Virus Nucleocapsids (1969)

Nucleocapsids released from influenza virions by sodium deoxycholate sedimented heterogeneously in sucrose gradients. Highly infectious virus (complete) preparations yielded nucleocapsids with peak distributions at 64 and 56S; von Magnus type virus (incomplete) lacked 64S nucleocapsids. Treatment of influenza virus nucleocapsids with pancreatic ribonuclease rendered the associated viral ribonucleic acid (RNA) molecules acid-soluble, indicating that capsid proteins do not completely surround the viral RNA's. However, the capsid proteins remained associated after enzymatic hydrolysis of the RNA, as judged by persistently high sedimentation rates. Sedimentation rates of viral nucleocapsids reflected the sedimentation rates of the associated RNA's: 64S nucleocapsids contained 18S RNA, whereas 56S nucleocapsids contained 15S RNA, although in both cases RNA's sedimenting at 4 to 13S were also recovered. Furthermore, just as incomplete virions lacked 64S nucleocapsids, they also lacked 18S RNA. These findings support the hypothesis that the influenza virus genome is divided among several distinct pieces of RNA.
THE ALLOANTIBODY NETWORK FOLLOWING INTRATHYMIC IMMUNOMODULATION OF SENSITIZED RAT RECIPIENTS OF CARDIAC ALLOGRAFTS1,2 (1995)

An intrathymic injection of allogeneic spleen cells (2×107) prevents accelerated (<36 hr) rejection in sensitized LEW rats, and prolongs the survival of LBNF1 cardiac allografts to about 11 days. This effect is donor-specific, x-irradiation-sensitive and thymus-dependent, and it does not require adjunctive immunosuppressive therapy. We have recently shown that following intrathymic allo-Ag injection, host cell proliferative responses in lymphoid organs are markedly depressed as compared with untreated sensitized recipients. Little is known about how intrathymic immunomodulation may affect host humoral alloreactivity. In this work, we studied the dynamic interplay between the humoral responses, both in the circulation and at the graft site of sensitized hosts. Intrathymic allo-Ag exposure triggered a profound change in the utilization pattern of alloreactive IgM, IgG, and IgG subclasses compared with recipients receiving syngeneic cells. Administration of allo-Ag into the thymus at the time of sensitization resulted in an earlier and significantly increased systemic production of IgM, as shown by flow cytometry. Subsequently, isotype switching to IgG occurred prematurely and resulted in elevated levels of IgG1 and IgG2a. Indeed, the addition of such allo-Ab enriched serum suppressed the MLR assay in a dose-dependent manner. The binding of Ig to cardiac allografts was analyzed in eluates by flow cytometry, and by immunohistochemical staining at day 1 after transplantation. Intragraft IgM and IgG levels were consistently higher in well-functioning grafts following administration of allo-Ag, as compared with controls. IgG deposits at the graft site consisted predominantly of IgG1 and IgG2a, while significant amounts of IgG2b could only be detected in control hosts undergoing accelerated graft rejection. These data document that intrathymic injection of donor-specific allo-Ag in sensitized recipients leads to profound alterations of the host humoral alloresponses, and that such elevated allo-Ab levels interfere with the Ag reactivity or alloresponsive effector cells in vitro. These results support the notion that the pattern of allo-Ab utilization is indicative of the functional status of the alloimmune response in the transplant recipient.
Color control of multilayer stacked white polymer light-emitting diodes using a quantum dot as an interlayer (2009)

Color tunable multilayer stacked white polymer light-emitting diodes (WPLEDs) have been developed using a quantum dot as an interlayer. Multilayer WPLEDs were fabricated by a stamp transfer printing method and the charge transport of WPLEDs could be controlled by the quantum dot interlayer. The use of the quantum dot as the interlayer shifted the color coordinate of blue/yellow stacked WPLEDs from (0.34, 0.41) to (0.41, 0.48). The electron trapping effect of the quantum dot was responsible for the color shift in the multilayer stacked WPLEDs.
Size-focality-invasion in upper tract urothelial carcinoma (SFI-UTUC): A novel imaging-based score to predict survival outcomes. (2018)

475 Background: Upper tract urothelial cell carcinoma (UTUC) is an uncommon malignancy with disparate outcomes. We developed a novel morphometric scoring system for prediction of oncologic and survival outcomes before nephroureterectomy (NU). Methods: Retrospective, multicenter analysis of UTUC patients who underwent NU after negative metastatic workup. Preoperative CT-urography was used to evaluate scores, based on 3 factors (Tumor Size, Focality, Invasion of architecture) with a score of 1-3 based on degree of each factor (total score 3-9). Primary outcome was overall survival (OS). Secondary outcomes were recurrence and recurrence free survival (RFS). Multivariable (MVA) and Kaplan-Meier (KMA) analyses were utilized. Results: We analyzed 244 patients (mean age 70.9, mean follow up 29.5 months). 61% with SFI-UTUC score 3-6 and 39% were score 7-9. No difference in age, gender, comorbid conditions, surgical approach, or complications between groups. Score 7-9 had a higher rate of pN+ disease (24.2% vs. 8.1%, p=0.002) but similar nuclear grade. All-cause mortality was higher for score 7-9 (47.4% vs. 28.9%, p=0.004). On MVA for all-cause mortality, age (OR 1.1), recurrence (OR 4.4) and score 7-9 (OR 2.0) were significant (p&lt;0.05). KMA for OS demonstrated 5 year OS of 57.0% for score 3-6 and 34.1% for score 7-9 (p&lt;0.01). KMA for RFS was significant for renal UTUC location with 5 year RFS of 72.3% for score 3-6 and 54.2% for score 7-9, (p&lt;0.01). Conclusions: A novel scoring system for UTUC preoperative imaging may predict OS for tumors in renal and ureteral locations, as well as RFS for renal locations. Renal location. [Table: see text]
An alternative to push, press, and tap-tap-tap (2007)

A gestural text entry method for mobile is presented. Unlike most mobile phone text entry methods, which rely on repeatedly pressing buttons, our gestural method uses an isometric joystick and the EdgeWrite alphabet to allow users to write by making letter-like "pressure strokes." In a 15-session study comparing character-level EdgeWrite to Multitap, subjects' speeds were statistically indistinguishable, reaching about 10 WPM. In a second 15-session study comparing word-level EdgeWrite to T9, the same subjects were again statistically indistinguishable, reaching about 16 WPM. Uncorrected errors were low, around 1% or less for each method. In addition, subjective results favored EdgeWrite. Overall, results indicate that our isometric joystick-based method is highly competitive with two commercial keypad-based methods, opening the way for keypad-less designs and text entry on tiny devices. Additional results showed that a joystick on the back could be used at about 70% of the speed of the front, and the front joystick could be used eyes-free at about 80% of the speed of normal use.
Determination of Ultimate Leakage Through Rutile <formula formulatype="inline"><tex Notation="TeX">$ \hbox{TiO}_{2}$</tex></formula> and Tetragonal <formula formulatype="inline"><tex Notation="TeX">$\hbox{ZrO}_{2}$</tex></formula> From Ab Initio Complex Band Calculations (2013)

First-principle complex band structures have been computed for rutile TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and tetragonal ZrO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> insulating materials that are of current technological relevance to dynamic random access memory metal-insulator-metal (MIM) capacitors. From the magnitude of the complex wave vectors in different orientations, the most penetrating orientations have been identified. Tunneling effective masses <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">tunnel</sub> have been extracted, are shown to be a crucial parameter for the intrinsic leakage, and are identified to be an important parameter in further scaling of MIM capacitors.
Desarrollo de vacunas orales basado en las propiedades protectivas y adyuvantes de las proteínas variables de superficie (VSPS) de giardia lamblia. (2014)

El protozoario parásito intestinal Giardia lamblia es el único microorganismo que coloniza el intestino superior de vertebrados, incluyendo al hombre. Esto es posible porque el mismo está recubierto de una densa capa protectora de proteínas ricas en cisteína que evitan la “digestión” del parásito por el pH ácido del estómago y la acción de las proteasas intestinales, llamadas VSPs por su sigla en Inglés. Nuestra hipótesis de trabajo es que estas VSPs pueden ser utilizadas para transportar antígenos vacunales para su administración por vía oral. Como se sabe, la mayoría de los agentes patógenos entran al cuerpo a través de las mucosas. Por ello, ya que las VSPs son capaces de inducir una fuerte respuesta inmune mucosal se desarrollarán diferentes estrategias para verificar su potencial utilización en formulaciones vacunales orales. Se comenzará con el modelo de Influenza y luego con otras enfermedades infecciosas de relevancia social.
Role of defects in ultra-high gain in fast planar tin gallium oxide UV-C photodetector by MBE (2022)

We report ultra-high responsivity of epitaxial (SnxGa1−x)2O3 (TGO) Schottky UV-C photodetectors and experimentally identified the source of gain as deep-level defects, supported by first principles calculations. Epitaxial TGO films were grown by plasma-assisted molecular beam epitaxy on (−201) oriented n-type β-Ga2O3 substrates. Fabricated vertical Schottky devices exhibited peak responsivities as high as 3.5 ×104 A/W at −5 V applied bias under 250 nm illumination with sharp cutoff shorter than 280 nm and fast rise/fall time in milliseconds order. Hyperspectral imaging cathodoluminescence (CL) spectra were examined to find the mid-bandgap defects, the source of this high gain. Irrespective of different tin mole fractions, the TGO epilayer exhibited extra CL peaks at the green band (∼2.20 eV) not seen in β-Ga2O3 along with enhancement of the blue emission-band (∼2.64 eV) and suppression of the UV emission-band. Based on hybrid functional calculations of the optical emission expected for defects involving Sn in β-Ga2O3, VGa–Sn complexes are proposed as potential defect origins of the observed green and blue emission-bands. Such complexes behave as acceptors that can efficiently trap photogenerated holes and are predicted to be predominantly responsible for the ultra-high photoconductive gain in the Sn-alloyed Ga2O3 devices by means of thermionic emission and electron tunneling. Regenerating the VGa–Sn defect complexes by optimizing the growth techniques, we have demonstrated a planar Schottky UV-C photodetector of the highest peak responsivity.
A Wearable Skin Temperature Monitoring System for Early Detection of Infections (2021)

This paper describes a wearable, open-source wrist temperature monitoring system that enables the reliable identification of slowly-varying skin temperature patterns that may be indicative of infections. The hardware platform uses a Bluetooth Low Energy (BLE) wireless interface and includes three skin temperature sensors, a thermally-isolated ambient temperature sensor, an inertial measurement unit (IMU), and a Galvanic skin response (GSR) sensor. A template-matching algorithm is used to detect weak but long-lived anomalous temperature patterns that deviate from the normal circadian rhythm are thus may be driven by infections. Experimental and simulation results confirm that small temperature anomalies (peak value <0.4°C) extending over 2–3 weeks can be detected with a total error rate <10%.
Structural Evidence for a [4Fe‐5S] Intermediate in the Non‐Redox Desulfuration of Thiouracil (2020)

Abstract We recently discovered a [Fe‐S]‐containing protein with in vivo thiouracil desulfidase activity, dubbed TudS. The crystal structure of TudS refined at 1.5 Å resolution is reported; it harbors a [4Fe‐4S] cluster bound by three cysteines only. Incubation of TudS crystals with 4‐thiouracil trapped the cluster with a hydrosulfide ligand bound to the fourth non‐protein‐bonded iron, as established by the sulfur anomalous signal. This indicates that a [4Fe‐5S] state of the cluster is a catalytic intermediate in the desulfuration reaction. Structural data and site‐directed mutagenesis indicate that a water molecule is located next to the hydrosulfide ligand and to two catalytically important residues, Ser101 and Glu45. This information, together with modeling studies allow us to propose a mechanism for the unprecedented non‐redox enzymatic desulfuration of thiouracil, in which a [4Fe‐4S] cluster binds and activates the sulfur atom of the substrate.