gebhart/patrepeval huggingface dataset:
Novel Roles of Focal Adhesion Kinase in Cytoplasmic Entry and Replication of Influenza A Viruses (2014)

We found that FAK links early activation of PI3K and actin reorganization, thereby regulating influenza virus entry. Surprisingly, we also found that FAK can regulate viral RNA replication independently of its role in entry. Our study addresses a knowledge gap in the understanding of signaling events triggered by influenza virus that mediate its internalization and initiation of the infection cycle. Understanding of these fundamental molecular events will be necessary to identify novel host targets, such as FAK, and development of future anti-influenza virus therapeutics.
FPGA routing and routability estimation via Boolean satisfiability (1998)

Guaranteeing or even estimating the routability of a portion of a placed field programmable gate array (FPGA) remains difficult or impossible in most practical applications. In this paper, we develop a novel formulation of both routing and routability estimation that relies on a rendering of the routing constraints as a single large Boolean equation. Any satisfying assignment to this equation specifies a complete detailed routing. By representing the equation as a binary decision diagram (BDD), we represent all possible routes for all nets simultaneously. Routability estimation is transformed to Boolean satisfiability, which is trivial for BDD's. We use the technique in the context of a perfect routability estimator for a global router. Experimental results from a standard FPGA benchmark suite suggest the technique is feasible for realistic circuits, but refinements are needed for very large designs.
37.5L: Late‐News Paper : Investigation of Conductivity of SrO: High Gamma Material for Protective Layer of AC‐PDPs (2011)

Abstract A PDP with SrO protective layer showed a grave deterioration of static voltage margin due to a conductivity of the protective layer. The conductivity of SrO in a realistic panel was analyzed by using an LCR meter. An activation energy related to the conductivity was 0.49 eV.
Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cells (2019)

Histone deacetylases (HDACs) are involved in diverse cellular regulatory mechanisms including non-canonical functions outside the chromatin environment. Several publications have demonstrated that selective HDAC inhibitors (HDACi) can influence tumor immunogenicity and the functional activity of specific immune cells. In particular, the selective inhibition of HDAC6 has been reported to decrease tumor growth in several malignancies. However, there is still no clarity about the cellular components mediating this effect. In this study, we evaluated the HDAC6i Nexturastat A as a priming agent to facilitate the transition of the tumor microenvironment from "cold" to "hot", and potentially augment immune check-point blockade therapies. This combination modality demonstrated to significantly reduce tumor growth in syngeneic melanoma tumor models. Additionally, we observed a complete neutralization of the up-regulation of PD-L1 and other immunosuppressive pathways induced by the treatment with anti-PD-1 blockade. This combination also showed profound changes in the tumor microenvironment such as enhanced infiltration of immune cells, increased central and effector T cell memory, and a significant reduction of pro-tumorigenic M2 macrophages. The evaluation of individual components of the tumor microenvironment suggested that the in vivo anti-tumor activity of HDAC6i is mediated by its effect on tumor cells and tumor-associated macrophages, and not directly over T cells. Overall, our results indicate that selective HDAC6i could be used as immunological priming agents to sensitize immunologically "cold" tumors and subsequently improve ongoing immune check-point blockade therapies.
(Invited) Strain Engineering for Fully-Depleted SOI Devices (2010)

Limitations of conventional strain engineering methods for fully-depleted SOI structure are reviewed and methods to extend these approaches to future FDSOI devices are discussed. The application of global strain engineering combined with biaxial to uniaxial strain conversion is shown to be promising. Finally, methods to utilize oxidation-induced strain engineering are introduced.
Decreased cerebrospinal fluid secretogranin II concentrations in severe forms of bipolar disorder (2013)

This study shows that the CSF marker secretogranin II has the potential to act as a biological marker for severe forms of bipolar disorder. Our findings indicate that patients with bipolar disorder possess defects in the regulatory secretory pathway, which may be of relevance to the progressive structural brain changes seen in those with severe forms of the disease.
Oculomotor Ophthalmoplegic Migraine in an Infant (1987)

SYNOPSIS Ophthalmoplegia is a rare presentation of migraine. Ophthalmoplegic migraine is frequently encountered in children, but has rarely been observed in infancy. We report a case of an infant with paroxysmal episodes of vomiting followed by a few weeks long periods of oculomotor nerve palsy. The first episode occurred at 14 months of age and the second at two years. In both episodes full recovery of the ophthalmoplegia occurred without treatment. The differential diagnosis of painful ophthalmoplegia and the variety of therapeutic regimens are discussed.
A Novel Host-Proteome Signature for Distinguishing between Acute Bacterial and Viral Infections (2015)

Bacterial and viral infections are often clinically indistinguishable, leading to inappropriate patient management and antibiotic misuse. Bacterial-induced host proteins such as procalcitonin, C-reactive protein (CRP), and Interleukin-6, are routinely used to support diagnosis of infection. However, their performance is negatively affected by inter-patient variability, including time from symptom onset, clinical syndrome, and pathogens. Our aim was to identify novel viral-induced host proteins that can complement bacterial-induced proteins to increase diagnostic accuracy. Initially, we conducted a bioinformatic screen to identify putative circulating host immune response proteins. The resulting 600 candidates were then quantitatively screened for diagnostic potential using blood samples from 1002 prospectively recruited patients with suspected acute infectious disease and controls with no apparent infection. For each patient, three independent physicians assigned a diagnosis based on comprehensive clinical and laboratory investigation including PCR for 21 pathogens yielding 319 bacterial, 334 viral, 112 control and 98 indeterminate diagnoses; 139 patients were excluded based on predetermined criteria. The best performing host-protein was TNF-related apoptosis-inducing ligand (TRAIL) (area under the curve [AUC] of 0.89; 95% confidence interval [CI], 0.86 to 0.91), which was consistently up-regulated in viral infected patients. We further developed a multi-protein signature using logistic-regression on half of the patients and validated it on the remaining half. The signature with the highest precision included both viral- and bacterial-induced proteins: TRAIL, Interferon gamma-induced protein-10, and CRP (AUC of 0.94; 95% CI, 0.92 to 0.96). The signature was superior to any of the individual proteins (P<0.001), as well as routinely used clinical parameters and their combinations (P<0.001). It remained robust across different physiological systems, times from symptom onset, and pathogens (AUCs 0.87-1.0). The accurate differential diagnosis provided by this novel combination of viral- and bacterial-induced proteins has the potential to improve management of patients with acute infections and reduce antibiotic misuse.
Immunoglobulin Deficient Mice Generated by Gene Targeting as Models for Studying the Immune Response (1996)

B cell deficient animals obtained by various strategies of gene targeting were used to study the B cell development and examine the role of different immune compartments in the immune response to microbes. Study of muMT, JHD, lambda 5T and JHT models of B cell deficiency, was essential in order to understand the role of pre-B cell receptor in B cell development, allelic exclusion and variable gene rearrangement regulation. In the immune response to influenza virus, a protective role of T cells in a total absence of B cell compartment, was revealed by studying the JHD -/- model. Further, it was established that a T cell compartment is sufficient to mediate the recovery from influenza infection. Examination of immune response in muMT and JHD models of definitive B cell deficiency to various blood stage Plasmodia species, showed that whereas B cells are not required for recovery from infection with P. chabaudi adami, P. vinckei petteri and P. chabaudi chabaudi (CB), B cell compartment is important in the later stages of infection with P. chabaudi chabaudi (AS). Studies carried out in muMT model suggested a possible role for T gamma delta subpopulation in the immune response to blood stage malaria parasite. B cell deficiency models are valuable for understanding the normal and pathological immune response. Studies carried out in muMT model indicated that T cell responses are not significantly affected in the absence of B cells. These data can neither rule out a role for B cells in T cell priming, nor in triggering an effective T cell help for humoral response. Study of double homozygous mice deficient for B cells and FAS or IL-2 gene, pinpointed the role of B cells in pathogenesis of lupus-like nephritis and vasculitis from lpr mouse and in hemolytic anemia from IL-2 -/- mouse model, respectively.
Simulation of mallet percussion instruments by a coupled modal vibroacoustic finite element model (2021)

A three-dimensional coupled vibroacoustic finite element model for physics-based simulations of the sound generation by mallet percussion instruments in the time domain is discussed in the present paper. The mechanical model takes the orthotropic material properties of the wooden sound bars and the nonlinear nature of the interaction force between the mallet head and the sound bar into account while the acoustical model considers radiation into an unbounded domain. A direct coupling of the sound bars, acoustical cavity resonators, and the excitation by a mallet is considered with exploiting the modal basis to reduce the number of degrees of freedom of the system. Both the mechanical and acoustical models are validated by comparing them to measurements performed on an Orff xylophone. A case study shows the capabilities of the coupled model, including the analysis of the energy balance, the effect of tuning the resonator, and the excitation of the torsional modes of the sound bar.
Coherent Laser Beam Addition with Holographic Binary Phase Gratings (1986)

Single lasers are usually limited in total output power by some physical mechanism. For example, GaAs lasers suffer catastrophic facet damage at output power levels exceeding a few tens of milliwatts. Other semiconductor lasers are constrained to low power output by heat dissipation limitations. We have developed a holographic method of laser beam addition which is capable of producing large optical powers from the coherent sum of many modular laser sources. The coherent addition of six GaAlAs lasers has been demonstrated.
Resistive Switching Memory: Nanoionic Resistive Switching Memories: On the Physical Nature of the Dynamic Reset Process (Adv. Electron. Mater. 1/2016) (2016)

Marchewka et al. investigate the reset kinetics of TaOx-based nano-crossbars using time-resolved voltage-pulse measurements in the sub-μs regime and numerical simulations in article number 1500233. The advanced simulation model of nonisothermal electronic-ionic drift-diffusion allows for studying donor migration and related filament evolution in the oxide layer, thus identifying the balance between donor drift and diffusion as the root cause of the gradual reset behavior.
Polysaccharide hydrogel based 3D printed tumor models for chemotherapeutic drug screening (2021)

A series of stable and ready-to-use bioinks have been developed based on the xeno-free and tunable hydrogel (VitroGel) system. Cell laden scaffold fabrication with optimized polysaccharide-based inks demonstrated that Ink H4 and RGD modified Ink H4-RGD had excellent rheological properties. Both bioinks were printable with 25-40 kPa extrusion pressure, showed 90% cell viability, shear-thinning and rapid shear recovery properties making them feasible for extrusion bioprinting without UV curing or temperature adjustment. Ink H4-RGD showed printability between 20 and 37 °C and the scaffolds remained stable for 15 days at temperature of 37 °C. 3D printed non-small-cell lung cancer (NSCLC) patient derived xenograft cells (PDCs) showed rapid spheroid growth of size around 500 µm in diameter and tumor microenvironment formation within 7 days. IC<sub>50</sub> values demonstrated higher resistance of 3D spheroids to docetaxel (DTX), doxorubicin (DOX) and erlotinib compared to 2D monolayers of NSCLC-PDX, wild type triple negative breast cancer (MDA-MB-231 WT) and lung adenocarcinoma (HCC-827) cells. Results of flow property, shape fidelity, scaffold stability and biocompatibility of H4-RGD suggest that this hydrogel could be considered for 3D cell bioprinting and also for in-vitro tumor microenvironment development for high throughput screening of various anti-cancer drugs.
Low power RF integrated circuits (1999)

Article Free Access Share on Low power RF integrated circuits: principles and practice Authors: A. A. Abidi Electrical Engineering Department, University of California, Los Angeles, CA Electrical Engineering Department, University of California, Los Angeles, CAView Profile , H. Darabi Electrical Engineering Department, University of California, Los Angeles, CA Electrical Engineering Department, University of California, Los Angeles, CAView Profile Authors Info & Claims ISLPED '99: Proceedings of the 1999 international symposium on Low power electronics and designAugust 1999 Pages 1–6https://doi.org/10.1145/313817.313824Published:17 August 1999Publication History 4citation733DownloadsMetricsTotal Citations4Total Downloads733Last 12 Months19Last 6 weeks6 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
A Tactile SensingforHuman-Centered Robotics (2006)

Hereweshowatactile sensing forhuman-centered robotics. Oneisamulti-fingered handsystemfortelepresence basedonthetactile information. Thesoft finger withthebuilt-in compact tactile sensor isdiscussed fromabiomimetic viewpoint. Another isatactile enhancing toolthatoperates notonlyasa disturbance filter, butalso, supposedly, asamagnifier ofsurface undulation. A simple physics isutilized togenerate theenhancing effect. I.INTRODUCTION
Electron beam collector with a low back flow (2003)

Generation of a DC electron beam in the future Fermilab electron cooler employs an electrostatic acceleration and a beam energy recovery, so that electrons are decelerated from the nominal energy of 4.3 MeV they have in the cooling section to few keV in the collector. Stable performance of this scheme requires a current loss /spl delta/I below 10 /spl mu/A at the beam current up to the nominal value of I=0.5 A. One of sources of the loss is a back flow of secondary electrons from the beam collector. The paper discusses principles and performance of a collector with the low current loss.
A Precision Polyanion for High Performance Lithium-Ion Transport in Polymer Blend Electrolytes (2022)

A novel precision single ion conductor with an N -((trifluoromethyl)sulfonyl)phenylsulfonimide lithium salt covalently bound to every fifth carbon of a polyethylene backbone, p 5PhTFSI-Li, was synthesized via post polymerization modification. The conversion to a trifluoromethanesulfonimide (TFSI) anion from the parent polymer bearing a phenylsulfonate anion was highly efficient (~90%) as determined by 19 F-NMR analysis and corroborated through other spectroscopic methods. The bulky and flexible TFSI anion led to a reduced and observable glass transition temperature of ~199 °C and an improved thermal stability up to ~375 °C. Blending of p 5PhTFSI-Li with poly(ethylene oxide) at various compositions was performed to investigate electrochemical performance and transference numbers with respect to the lithium electrode using a combination of impedance and polarization methods. At 90 °C, this system displayed high conductivity up to 2.00 X 10 -4 S cm -1 and transference numbers were near unity independent of temperature, making this system highly competitive with other polyanion/polyether blend electrolytes. Investigations into the complex miscibility and phase behavior of these blends at various compositions was also probed by a combination of microscopy and differential scanning calorimetry.
Impact of low intensity millimeter-waves on cell membrane permeability (2009)

As the applications and commercial uses of millimeter- and submillimeter-waves grow, we should take a more detailed look at the impact this frequency range has on biological systems. This paper examines one specific effect of low-level (10-50 times the MPE - maximum permissible exposure) 60 GHz CW RF power on cells - the opening of voltage sensitive cation channels.
Resistance Analyses of HCV NS3/4A Protease and NS5B Polymerase from Clinical Studies of Deleobuvir and Faldaprevir (2016)

Faldaprevir and deleobuvir RAVs are more prevalent among virologic failures than at baseline. Treatment response was not compromised by common NS3 polymorphisms; however, alanine at NS5B amino acid 499 at baseline (wild-type in GT-1a, polymorphism in GT-1b) may reduce response to this deleobuvir-based regimen.
Effect of high energy electron irradiation on low frequency noise in 4H-SiC Schottky diodes (2017)

The low-frequency noise in high voltage Ni/4H-SiC Schottky diodes irradiated with high energy (0.9 MeV) electrons was studied in the frequency range from 1 Hz to 50 kHz, temperature interval 295–410 K, and irradiation dose Φ from 0.2 × 1016 cm−2 to 7 × 1016 cm−2. The noise amplitude was found monotonically increasing with the irradiation dose. With the irradiation dose increase, the noise spectra on the linear part of the current voltage characteristic transform from the 1/f noise to the generation recombination noise of at least two trap levels. One of these levels can be classified as Z1/2 with the capture cross section determined from the noise measurements to be ∼10−15 cm2.
Real-Time Finger Gaits Planning for Dexterous Manipulation (2017)

Dexterous manipulation has broad potential applications in assembly lines, warehouses and agriculture, and so on. To perform large-scale, complicated manipulation tasks, a multi-fingered robotic hand sometimes has to sequentially adjust its grasping status, i.e. the finger gaits, to deal with the workspace limits and object stability. However, realizing finger gaits planning in dexterous manipulation is challenging due to the involved hybrid dynamics, complicated grasp quality metrics, and uncertainties during the finger gaiting. In this paper, a dual-stage optimization based controller is proposed to handle these challenges. First, a velocity-level finger gaits planner is introduced by combining object grasp quality with hand kinematic limitations. The proposed finger gaits planner is computationally efficient and can be solved in real-time. Second, a manipulation controller using force optimization is presented. To deal with mass uncertainties and external disturbances, a modified impedance control is integrated into the manipulation controller. The dual-stage controller does not require the shape of the object, nor does it rely on expensive 3D/6D tactile sensors. Simulation results verify the efficacy of the proposed dual-stage controller.
Impedance Control Network-Based Inverters for High-Frequency Capacitive Wireless Power Transfer Systems (2022)

High-power large air-gap capacitive wireless power transfer (WPT) systems require paralleling either the semiconductor devices in their high-frequency inverters or paralleling the inverters themselves due to limited current rating of available gallium nitride (GaN) transistors. This paper introduces a method to parallel inverters in capacitive WPT systems suitable for electric vehicle (EV) charging based on an impedance control network (ICN) architecture. The ICN architecture helps combine power from two high-frequency inverters by effectively suppressing the impact of any mismatches between them, thereby doubling the power transfer capability of the capacitive WPT system. A comprehensive design methodology to design an ICN-based capacitive WPT system is presented. Furthermore, an auxiliary zero voltage switching (ZVS) circuit to achieve ZVS soft switching of all the inverters' transistors is also designed. The auxiliary ZVS circuit-based approach reduces the circulating currents in the matching networks and ensures equal power processing by both the inverters. For experimental validation, a 6.78-MHz 12-cm air-gap kilowatt-scale ICN-based capacitive WPT system is designed, built and tested up to 1800 W output power. The experimental results are in good agreement with the theoretical predictions.
A simple and practical 157nm and 193 nm coherent light source (2008)

We demonstrate a fully-coherent ultrafast UV light source at 193 and 157 nm using a cascaded four wave mixing technique in a hollow dielectric waveguide. We have obtained 200 nJ and 20 nJ per pulse energy at 193 nm and 157 nm respectively using pulses of 200uJ pulse energy and 50 fs pulse width from a Ti:sapphire regenerative amplifier at 5 kHz. Our technique can easily be scaled to 100 kHz repetition rate for use in defect inspection for lithography development and many ultrafast spectroscopy experiments.
Structural basis for the extended substrate spectrum of CMY‐10, a plasmid‐encoded class C β‐lactamase (2006)

The emergence and dissemination of extended-spectrum (ES) beta-lactamases induce therapeutic failure and a lack of eradication of clinical isolates even by third-generation beta-lactam antibiotics like ceftazidime. CMY-10 is a plasmid-encoded class C beta-lactamase with a wide spectrum of substrates. Unlike the well-studied class C ES beta-lactamase from Enterobacter cloacae GC1, the Omega-loop does not affect the active site conformation and the catalytic activity of CMY-10. Instead, a three-amino-acid deletion in the R2-loop appears to be responsible for the ES activity of CMY-10. According to the crystal structure solved at 1.55 A resolution, the deletion significantly widens the R2 active site, which accommodates the R2 side-chains of beta-lactam antibiotics. This observation led us to demonstrate the hydrolysing activity of CMY-10 towards imipenem with a long R2 substituent. The forced mutational analyses of P99 beta-lactamase reveal that the introduction of deletion mutations into the R2-loop is able to extend the substrate spectrum of class C non-ES beta-lactamases, which is compatible with the isolation of natural class C ES enzymes harbouring deletion mutations in the R2-loop. Consequently, the opening of the R2 active site by the deletion of some residues in the R2-loop can be considered as an operative molecular strategy of class C beta-lactamases to extend their substrate spectrum.