gebhart/patrepeval huggingface dataset:
Synthesis of (±)-6β-prostaglandin I1and (±)-6β-decarboxyprostaglandin I1 (1981)

The known hydroxy-aldehyde (5) has been converted into 6β-decarboxyprostaglandin I1(19) and 6β-prostaglandin I1(3) by (i) reaction with an appropriate organometallic reagent, (ii) cyclisation via the intermediate formation of an iodonium ion, and (iii) hydrodeiodination and desilylation.
SunDown (2020)

Solar arrays often experience faults that go undetected for long periods of time, resulting in generation and revenue losses. In this paper, we present SunDown, a sensorless approach for detecting per-panel faults in solar arrays. SunDown's model-driven approach leverages correlations between the power produced by adjacent panels to detect deviations from expected behavior, can handle concurrent faults in multiple panels, and performs anomaly classification to determine probable causes. Using two years of solar data from a real home and a manually generated dataset of solar faults, we show that our approach is able to detect and classify faults, including from snow, leaves and debris, and electrical failures with 99.13% accuracy, and can detect concurrent faults with 97.2% accuracy.
Fiber Bragg grating inscription in pure-silica and Ge-doped photonic crystal fibers (2009)

We report on fiber Bragg gratings (FBGs) inscribed in pure-silica and Ge-doped photonic crystal fibers (PCFs) with a two-beam interference technique and a femtosecond or excimer laser. Such a technique enables the inscription of FBGs for different Bragg wavelengths with high flexibility. Effects of H(2)-loading and Ge doping on the efficiency of grating inscription were investigated by measuring the development of Bragg wavelength and attenuation in the transmission spectra with an increased exposure dose. H(2)-loading dramatically enhances the laser-induced index modulation not only in Ge-doped PCFs but also in pure-silica PCFs. We observed a reversible Bragg wavelength shift during femtosecond pulse irradiation, which indicates an internal temperature rise of approximately 77 degrees C.
A Specialized Lightweight Metamorphic Function for KASUMI Metamorphic Cipher and Its FPGA Implementation (2016)

To enhance the performance of the KASUMI Metamorphic Cipher, we apply a lightweight Metamorphic Structure. The proposed structure uses four lightweight bit-balanced operations in the function Meta-FO of the KASUMI Metamorphic Cipher. These operations are: XOR, INV, XNOR, and NOP for bitwise XOR, invert, XNOR, and no operation respectively building blocks of the Specialized Crypto Logic Unit (SCLU). In this work, we present a lightweight KASUMI Specialized-Metamorphic Cipher. In addition, we provide a Field Programmable Gate Array (FPGA) implementation of the proposed algorithm modification.
ARL4, an ARF-like Protein That Is Developmentally Regulated and Localized to Nuclei and Nucleoli (2000)

ADP-ribosylation factors (ARFs) are highly conserved approximately 20-kDa guanine nucleotide-binding proteins that participate in both exocytic and endocytic vesicular transport pathways via mechanisms that are only partially understood. Although several ARF-like proteins (ARLs) are known, their biological functions remain unclear. To characterize its molecular properties, we cloned mouse and human ARL4 (mARL4 and hARL4) cDNA. The appearance of mouse ARL4 mRNA during embryonic development coincided temporally with the sequential formation of somites and the establishment of brain compartmentation. Using ARL4-specific antibody for immunofluorescence microscopy, we observed that endogenous mARL4 in cultured Sertoli and neuroblastoma cells was mainly concentrated in nuclei. When expressed in COS7 cells, ARL4-T34N mutant, predicted to exist with GDP bound, was concentrated in nucleoli. Yeast two-hybrid screening and in vitro protein-interaction assays showed that hARL4 interacted with importin-alpha through its C-terminal NLS region and that the interaction was not nucleotide-dependent. Like ARL2 and -3, recombinant hARL4 did not enhance cholera toxin-catalyzed auto-ADP-ribosylation. Its binding of guanosine 5'-O-(thiotriphosphate) was modified by phospholipid and detergent, and the N terminus of hARL4, like that of ARF, was myristoylated. Our findings suggest that ARL4, with its distinctive nuclear/nucleolar localization and pattern of developmental expression, may play a unique role(s) in neurogenesis and somitogenesis during embryonic development and in the early stages of spermatogenesis in adults.
Understanding the Surface Structure of LiNi0.45Mn1.55O4 Spinel Cathodes with Aberration-Corrected HAADF STEM (2014)

Journal Article Understanding the Surface Structure of LiNi0.45Mn1.55O4 Spinel Cathodes with Aberration-Corrected HAADF STEM Get access C Amos, C Amos Materials Science and Engineering Program, The University of Texas at Austin, Austin, TX, 78712 Search for other works by this author on: Oxford Academic Google Scholar J Song, J Song Materials Science and Engineering Program, The University of Texas at Austin, Austin, TX, 78712 Search for other works by this author on: Oxford Academic Google Scholar J Goodenough, J Goodenough Materials Science and Engineering Program, The University of Texas at Austin, Austin, TX, 78712 Search for other works by this author on: Oxford Academic Google Scholar PJ Ferreira PJ Ferreira Materials Science and Engineering Program, The University of Texas at Austin, Austin, TX, 78712 Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 20, Issue S3, 1 August 2014, Pages 448–449, https://doi.org/10.1017/S1431927614003961 Published: 27 August 2014
Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS (2005)

Difficulties in understanding the mechanisms of HIV neuropathogenesis include the inability to study dynamic processes of infection, cumulative effects of the virus, and contributing host immune responses. We used H magnetic resonance spectroscopy and studied monocyte activation and progression of CNS neuronal injury in a CD8 lymphocyte depletion model of neuroAIDS in SIV-infected rhesus macaque monkeys. We found early, consistent neuronal injury coincident with viremia and SIV infection/activation of monocyte subsets and sought to define the role of plasma virus and monocytes in contributing to CNS disease. Antiretroviral therapy with essentially non-CNS-penetrating agents resulted in slightly decreased levels of plasma virus, a significant reduction in the number of activated and infected monocytes, and rapid, near-complete reversal of neuronal injury. Robust macrophage accumulation and productive virus replication were found in brains of infected and CD8 lymphocyte-depleted animals, but no detectable virus and few scattered infiltrating macrophages were observed in CD8 lymphocyte-depleted animals compared with animals not receiving antiretroviruses that were sacrificed at the same time after infection. These results underscore the role of activated monocytes and monocyte infection outside of the brain in driving CNS disease.
Procedimiento para la preparación de un aceite semejante al de jojoba utilizando zeolitas ultraestables como catalizador (1992)

Referencia OEPM: P9100429.-- Fecha de solicitud: 19/02/1991.-- Titulares: Universidad Politecnica de Valencia (UPV).
Cobalt(I)‐Catalyzed Asymmetric [2 + 2 + 2] Cycloaddition of Alkynes and Nitriles: Synthesis of Enantiomerically Enriched Atropoisomers of 2‐Arylpyridines. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
A DODAG Metric Used for DODAG Selection in Low-Power and Lossy Networks (1999)

This document extends [RFC6551] by defining a new DODAG metric called
DODAG size, which can be used for DODAG selection in Low-Power and
Lossy Networks (LLNs). DODAG size is an important metric for nodes to
decide which DODAG to join, or which DODAG to migrate. This document
proposes methods to disseminate DODAG size from the Root to all nodes
in the DODAG, so that the DODAG size can be advertised to new joining
nodes.
Deep Profiling of the CD8+ T-cell Compartment Identifies Activated Cell Subsets and Multifunctional Responses Associated With Control of Cytomegalovirus Viremia (2018)

Uncontrolled CMV viremia is associated with specific clusters of memory T-cell subsets and lower frequencies of HCMV-specific multifunctional CD8 T cells.
High precision automated alignment procedure for two-mirror telescopes (2019)

A significant challenge in the production of Earth observation satellites is the precise alignment of the telescope optical components. We have developed a strategy to perform automated alignment of two-mirror telescopes for use in a realistic factory-based setting. A Ritchey-Chrétien telescope was used as an example. The secondary mirror was mounted on a high precision hexapod and its misalignment inferred from the Zernike coefficients for tilt, defocus, and coma, as measured by a phase-shifting interferometer. The required corrections to the position of the secondary mirror were implemented using an integral controller and alignment was achieved within minutes, compared to within days when using a manual alignment process. The Zernike coefficient for each aberration was reduced to within one standard deviation of the fluctuations due to residual instability (48 nm).
Inequivalence Magnetique Due a la Presence d'un Atome de Phosphore Asymetrique ou Pseudo‐Asymetrique (1970)

Abstract Dans les phosphinates d'alcoyle RPH(O)OR′, la présence de l'atome de phosphore asymétrique induit des inéquivalences magnétiques au niveau de protons ou groupes méthyles géminés. Si le reste alcoxy OR' comporte lui aussi un atome de carbone asymétrique, la résonance magnétique de 31 P et de 1 H, permet de mettre en évidence la formation des deux diastéréoisoméres attendus, en proportions égales. Par ailleurs, la résonance magnétique de 31 P révèle le caractère de centre de pseudo‐asymétrie de l'atome de phosphore dans les esters phosphoneux de l'alcool butylique secondaire.
Ultrafast capillary electrophoresis/mass spectrometry with adjustable porous tip for a rapid analysis of protein digest in about a minute (2013)

As a proof of concept, the application of UFCE-MS was demonstrated by the analysis of a peptide mixture and a protein digest in ~1 min.
Data from Antibody-Drug Conjugates for the Treatment of Non–Hodgkin's Lymphoma: Target and Linker-Drug Selection (2023)

&lt;div&gt;Abstract&lt;p&gt;Antibody-drug conjugates (ADC), potent cytotoxic drugs covalently linked to antibodies via chemical linkers, provide a means to increase the effectiveness of chemotherapy by targeting the drug to neoplastic cells while reducing side effects. Here, we systematically examine the potential targets and linker-drug combinations that could provide an optimal ADC for the treatment for non–Hodgkin's lymphoma. We identified seven antigens (CD19, CD20, CD21, CD22, CD72, CD79b, and CD180) for potential treatment of non–Hodgkin's lymphoma with ADCs. ADCs with cleavable linkers mediated &lt;i&gt;in vivo&lt;/i&gt; efficacy via all these targets; ADCs with uncleavable linkers were only effective when targeted to CD22 and CD79b. In target-independent safety studies in rats, the uncleavable linker ADCs showed reduced toxicity, presumably due to the reduced release of free drug or other toxic metabolites into the circulation. Thus, our data suggest that ADCs with cleavable linkers work on a broad range of targets, and for specific targets, ADCs with uncleavable linkers provide a promising opportunity to improve the therapeutic window for ADCs in humans. [Cancer Res 2009;69(6):2358–64]&lt;/p&gt;&lt;/div&gt;
OBSERVATION OF $CH_{2}$ IN A PULSED SUPERSONIC EXPANSION (1979)

$^{1}$ G. Herzberg, Proc. R. Soc. (Lond.) A 262, 291 (1961); G. Herzberg and J. W. C. Johns, Proc. R. Soc. (Lond.) A 295, 107 (1966); D. Feldman, K. Meier, R. Schmiedl, and K. H. Welge, chem. Phys. Lett. 60, 30 (1978).
An Optimized On-Chip Boost-Type DC-DC Converter With an On-Board Inductance (2014)

The rapid development of portable electronic products in recent years increases demands of varied displays. With resolutions of panel sizes and pixels under current drive capability improved, this study is intended for designing an inductive DC boost converter circuit for displays, which is fully integrated with IC fabrication technology [1][2]. Most of current displays employ capacitances for voltage-boosting to supply relative high-voltage biases to displays. These booster circuits are in small sizes and with high efficiency, but limited output currents, which are inadequate for some of large-sized displays. To remedy the problem, an on-board, small-sized inductor in the forms of coils in a printed circuit board (PCB) is proposed for a superior solution. This PCB-type inductor can be incorporated into the same board with other drive chips for the displays, while offering large, adequate current, as an incapable task via an on-chip coil.
Electron Energy Dependence of Regioselective Chloride Ion Loss from Polychlorodibenzo-p-dioxins. Relationship between Resonance Electron Energies and Virtual Orbital Energies (1999)

Regiospecifically chlorine-37-labeled polychlorodibenzo-p-dioxins (PCDDs) undergo electron energy-dependent regioselective chloride ion loss when analyzed by electron capture negative ion mass spectrometry using an electron monochromator to supply the slow monoenergetic electrons. Three negative ion resonances, produced with electrons of energies <0.5, ∼1, and ∼4 eV are associated with the production of chloride ions from PCDDs. Negative ion resonances for the production of molecular ions of higher PCDDs were recorded with electrons of energies <0.2 eV. Dichlorodibenzo-p-dioxins and some trichlordibenzo-p-dioxins showed no molecular ions. A correlation was found between the experimental electron attachment energies and the virtual orbital energies calculated by modified density functional theory methods using the B3LYP/D95//B3LYP/D95 level of theory. The results from these correlations strongly suggest that all negative ion-forming processes for this class of compounds are initiated from π* states. The loss of chloride ion from transient negative PCDD ions requires π*−σ* orbital mixing.
Effect of Cationic Contaminants on Polymer Electrolyte Fuel Cell Performance (2013)

To correlate the cationic contaminant uptake of the membrane electrode assembly (MEA) with the polymer electrolyte fuel cell (PEFC) performance, MEAs were contaminated by saturating in varying concentrations of H2SO4 and Al2(SO4)3 solution to establish ex situ equilibrium cation uptake. The MEAs were then assembled and tested in a single cell hardware to determine the performance as a function of cationic contamination level. Smaller MEA coupons were also saturated at the same time as full-size MEA and were characterized to determine the cationic occupation fraction by acid site titration. It is found that the acid site occupation in the MEA increased and the cell performance decreased with increased Al ion concentration in the solution. With less than 10% occupation, the cell performance dropped from 1000 mA/cm2 to 100 mA/cm2 at 0.6 V. Upon re protonation of the MEA with H2SO4, it is found the cell performance was fully recovered.
Validation of a rapid ultra‐high‐performance liquid chromatography–tandem mass spectrometry method for quantification of chlorogenic acids in roasted coffee (2020)

Chlorogenic acids (CGAs) are a large class of esters formed between quinic acid and hydroxycinnamic acids. They are present in coffee as a complex mixture of positional and geometric isomers, where caffeoylquinic acids (CQAs) are the most abundant, followed by dicaffeoylquinic acids (diCQAs), feruloylquinic acids (FQAs), and p-coumaroylquinic acids (p-CoQAs). The aim of this work is to develop a new reliable and fast liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for simultaneous identification and quantification of total amount of 11 CGAs in roasted coffee. Regarding sample preparation step, aqueous methanol and 100% aqueous ultrasonic extractions were evaluated. For the filtration Step 4, different membranes were tested, in order to fill the void of complete evaluation of extractables recovery when using different membranes, highlighting an incomplete recovery when using nylon filters. An LC/electrospray ionization (ESI)-MS/MS method was developed and validated following the European rules in terms of specificity, linearity, concentration range, limit of detection (LOD) and limit of quantification (LOQ), precision, and trueness, in order to obtain a useful quality control tool for roasted coffee. The method was applied for quantification of CGAs of a roasted coffee sample previously characterized by an interlaboratory circuit (LVU), and results were compared with the quantitation of CGAs via UHPLC-DAD. The quantitative results were expressed as 5-CQA equivalents, and the validation of this approach opens the way to reliable, cheap, and environmental-friendly tools for quality control purposes.
The synthesis and butyllithium catalyzed polymerization of 9‐acrylylcarbazole (1964)

Abstract 9‐Acrylylcarbazole was synthesized and its polymerization with n ‐butyllithium studied. It was found that in toluene at temperatures below 0°C. high conversions were realized, but above 0°C. the yields rapidly decreased. The polymers were high melting and insoluble, indicating that stereoregular polymers were formed. Solubility, polymer melt temperature, and infrared studies suggested that the stereoregularity increases with increasing polymerization temperature. Similar polymerizations in tetrahydrofuran produced only nonstereoregular polymers. X‐ray diffraction studies indicated a very low degree of crystallinity. Glass transition temperatures and densities of a series of polymers were measured and the results interpreted by assuming that the polymers have stereoregular sequences of differing length and that these sequences affect both chain stiffness and chain packing efficiencies.
ZnNixMnxCo2–2xO4 Spinel as a High‐Voltage and High‐Capacity Cathode Material for Nonaqueous Zn‐Ion Batteries (2018)

Abstract Nonaqueous Zn‐ion batteries are regarded as one alternative for Li‐ion batteries. Such batteries not only afford attractive attributes of cost, but also embody the advantages of the high‐specific capacities of Zn anodes, as well as the wide potential window of nonaqueous electrolytes. To fully exploit these advantages, improved cathode materials are highly desired. In this manuscript, a new series of spinels, ZnNi x Mn x Co 2–2 x O 4 , are reported as cathode materials for nonaqueous Zn‐ion batteries. Full cells constructed using this new spinel ( x = 1/2) as a cathode paired with a metal anode showed capacities over 200 cycles of 174 mAh g −1 and an open circuit potential of 2.05 V. The battery exhibits an energy density of 305 Wh kg −1 , which is the highest energy density yet reported for a Zn‐intercalation cathode. The data show that the Zn 2+ ions reversibly intercalate into the spinel structure during the charge/discharge processes, a compositional transformation directly correlated with a multiply reversible conversion between Co 4+ /Co 3+ , Ni 4+ /Ni 3+ /Ni 2+ , and Mn 4+ /Mn 3+ oxidation states within the lattice. The data suggest that Mn, Ni cosubstitution for Co in ZnCo 2 O 4 is an efficient method to facilitate Zn‐deintercalation and enhance discharge capacity, which may provide some guidelines for designing more attractive multivalent cathodes materials.
The 2018 Chitranjan S. Ranawat, MD Award: Developing and Implementing a Novel Institutional Guideline Strategy Reduced Postoperative Opioid Prescribing After TKA and THA (2018)

Level II, therapeutic study.
Global Acoustic Mapping of Ocean Temperatures (GAMOT) (2002)

The Kaneohe source experiment in the 1980s demonstrated the feasibility of using sound to monitor global warming trends in the ocean with sound. This experiment used a source cabled to shore and the Navy's SOSUS stations for receivers. The GAMOT group is developing new instruments to obtain similar data in near-real time but at about one-eighth the cost of instruments cabled to shore. This approach has the potential for obtaining global ocean measurements of temperature at 500 km resolution less expensively than that routinely expended for measuring atmospheric temperatures. GAMOT is using state-of-the art models of the ocean to interpret temperature changes.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Compact Hardware Implemenations of the SHA-3 Candidates ARIRANG, BLAKE, Grøstl, and Skein (2009)

The weakening of the widely used SHA-1 hash function has also cast doubts on the strength of the related algorithms of the SHA-2 family. The US NIST has therefore initiated the SHA-3 competition in order to select a modern hash function algorithm as a “backup” for SHA-2. This algorithm should be efficiently implementable both in software and hardware under different constraints. In this paper, we present hardware implementations of the four SHA-3 candidates ARIRANG, BLAKE, Grostl, and Skein with the primary constraint of minimizing chip area.
Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11 (1998)

The lethal factor (LF) toxin that is produced by Bacillus anthracis plays an important role in the pathogenesis of anthrax. LF has mononuclear phagocyte-specific intoxicating effects that are not well understood. We have identified genetic differences in inbred mouse strains that determine whether their cultured macrophages are susceptible to the cytolytic effect of LF intoxication. Our identification of resistant and susceptible mouse strains enabled us to analyse crosses between these strains and to map a single responsible gene (called Ltx1) to chromosome 11. Ltx1 probably influences intoxication events that occur after the delivery of LF to the cytosol, as all mouse macrophages are killed by polypeptides containing the catalytic domain of Diphtheria toxin fused to the domain of LF required for cytosolic transport. Furthermore, the susceptibility phenotype is dominant to resistance, suggesting that resistance is caused by an absence of or polymorphism in a molecule that acts jointly with, or downstream of, the activity of LF. Our mapping of Ltx1 is a crucial first step in its positional cloning, which will provide more information about the mechanism of LF intoxication.
Transition metal oxo-polymers synthesised via sol-gel chemistry (1992)

International audience
Exploiting Local Orientation Similarity for Efficient Ray Traversal of Hair and Fur (2014)

Hair and fur typically consist of a large number of thin, curved, and densely packed strands which are difficult to ray trace efficiently. A tight fitting spatial data structure, such as a bounding volume hierarchy (BVH), is needed to quickly determine which hair a ray hits. However, the large number of hairs can yield a BVH with a large memory footprint (particularly when hairs are pre-tessellated), and curved or diagonal hairs cannot be tightly bounded within axis aligned bounding boxes. In this paper, we describe an approach to ray tracing hair and fur with improved efficiency, by combining parametrically defined hairs with a BVH that uses both axis-aligned and oriented bounding boxes. This BVH exploits similarity in the orientation of neighboring hairs to increase ray culling efficiency compared to purely axis-aligned BVHs. Our approach achieves about 2× the performance of ray tracing pre-tessellated hair models, while requiring significantly less memory.
Multi-Parameter Fluorescence Detection at the Single-Molecule Level : Techniques and Applications (2001)

Fluorescence-based assays using single-molecule techniques are evolving into a very important tool in science. These techniques include not only direct detection and analysis of single-molecule events, but also spectroscopic analysis through fluctuation methods such as FCS (fluorescence correlation spectroscopy) or FIDA (fluorescence intensity distribution analysis). What are the advantages of these