gebhart/patrepeval huggingface dataset:
Supplementary Figure 1 from Alveolar Hypoxia Promotes Murine Lung Tumor Growth through a VEGFR-2/EGFR-Dependent Mechanism (2023)

&lt;p&gt;PDF file - 1.9MB, Mice injected with urethane or MCA/BHT and exposed to normoxia or hypoxia were weighed once a week. Hematocrits were obtained at the end of the experiment. Figure 1 A and B shows body weights in the urethane and MCA/BHT model and and Figures I C and D hematocrits. Data shown is mean � SEM and * indicates p &lt; minus 0.05 for comparisons between normoxia and hypoxia.&lt;/p&gt;
Negative biomarker based male fertility evaluation: Sperm phenotypes associated with molecular-level anomalies (2015)

Biomarker-based sperm analysis elevates the treatment of human infertility and ameliorates reproductive performance in livestock. The negative biomarker-based approach focuses on proteins and ligands unique to defective spermatozoa, regardless of their morphological phenotype, lending itself to analysis by flow cytometry (FC). A prime example is the spermatid specific thioredoxin SPTRX3/TXNDC8, retained in the nuclear vacuoles and superfluous cytoplasm of defective human spermatozoa. Infertile couples with high semen SPTRX3 are less likely to conceive by assisted reproductive therapies (ART) and more prone to recurrent miscarriage while low SPTRX3 has been associated with multiple ART births. Ubiquitin, a small, proteolysis-promoting covalent posttranslational protein modifier is found on the surface of defective posttesticular spermatozoa and in the damaged protein aggregates, the aggresomes of spermiogenic origin. Semen ubiquitin content correlates negatively with fertility and conventional semen parameters, and with sperm binding of lectins LCA (Lens culinaris agglutinin; reveals altered sperm surface) and PNA (Arachis hypogaea/peanut agglutinin; reveals acrosomal malformation or damage). The Postacrosomal Sheath WWI Domain Binding Protein (PAWP), implicated in oocyte activation during fertilization, is ectopic or absent from defective human and animal spermatozoa. Consequently, FC-parameters of PAWP correlate with ART outcomes in infertile couples and with fertility in bulls. Assays based on the above biomarkers have been combined into multiplex FC semen screening protocols, and the surface expression of lectins and ubiquitin has been utilized to develop nanoparticle-based bull semen purification method validated by field artificial insemination trials. These advances go hand-in-hand with the innovation of FC-technology and genomics/proteomics-based biomarker discovery.
Impact of Experimental Hookworm Infection on the Human Gut Microbiota (2014)

The interactions between gastrointestinal parasitic helminths and commensal bacteria are likely to play a pivotal role in the establishment of host-parasite cross-talk, ultimately shaping the development of the intestinal immune system. However, little information is available on the impact of infections by gastrointestinal helminths on the bacterial communities inhabiting the human gut. We used 16S rRNA gene amplification and pyrosequencing to characterize, for the first time to our knowledge, the differences in composition and relative abundance of fecal microbial communities in human subjects prior to and following experimental infection with the blood-feeding intestinal hookworm, Necator americanus. Our data show that, although hookworm infection leads to a minor increase in microbial species richness, no detectable effect is observed on community structure, diversity or relative abundance of individual bacterial species.
A statistical methodology for wire-length prediction (2006)

In this paper, the classic wire-length estimation problem is addressed and a new statistical wire-length estimation approach that captures the probability distribution function of net lengths after placement and before routing is proposed. These types of models are highly instrumental in formalizing a complete and consistent probabilistic approach to design automation and design closure where, along with optimizing the pertinent cost function, the associated prediction error is also considered. The wire-length prediction model was developed using a combination of parametric and nonparametric statistical techniques. The model predicts not only the length of the net using input parameters extracted from the floorplan of a design, but also probability distributions that a net with given characteristics after placement will have a particular length. The model is validated using the learn-and-test and resubstitution techniques. The model can be used for a variety of purposes, including the generation of a large number of statistically sound, and therefore realistic, instances of designs. The net models were applied to the probabilistic buffer-insertion problem and substantial improvement was obtained in net delay after routing (~ 20%) when compared to a traditional bounding box (BBOX)-based buffer-insertion strategy
Transient Thermal Investigation for a SmartMOS Based Airbag Circuit Driver (2002)

A numerical study was conducted to model the transient thermal behavior of an airbag squib driver using commercially available software. The squib driver is part of an airbag deployment IC. The simulations were primarily used to predict the thermal gradient across the die for determining the optimal sensor location for thermal shutdown that would protect the device from destruction. The temperature sensor should be placed such that it gets hot enough for any electrical pulses that heat up the device close to the destruction point. The overall purpose is to provide a thermal detection circuit for disabling current prior to reaching a thermally destructive level. A preliminary wafer level study correlates the simulated and measured values and indicates that the junction temperature is lower for the case with thicker die and adiabatic boundary conditions; an opposite trend is observed for the cases with fixed temperature boundary condition attached to the domain bottom side. The study of the high IC side dissipating 80W for 5 ms indicates that the bottom and top center monitor points reach temperatures of 188.2°C and 130.5°C at the end of the 5 ms timeframe, corresponding to a peak source temperature of 294.6°C. A similar study with 30W uniform dissipation for 20 ms indicates that the peak junction temperature is lower than before (220°C vs. 294°C). The study of the low IC side reveals higher peak temperatures compared to the high side, due to the larger power density for these cases. The peak temperatures are 368.7°C for 50W/5 ms, and 301.8°C for 25W/20 ms. The left monitor point temperature ranges between 210°C–260°C while the right monitor point temperature ranges between 140°C–160°C. The thermal investigation of the package after the thermal shutdown predicted the time needed for the FETs to reach predetermined temperatures for different scenarios. The temperatures of the low side FETs drop by almost 50% within the 30 ms following the 20 ms of constant powering at 50W. When the high-side FETs are powered at 80W for 5 ms then cooled, the temperature rises then decays within 0.1 s.
Synthesis and Biophysical Properties of Constrained d-Altritol Nucleic Acids (cANA) (2013)

The first synthesis of constrained altritol nucleic acids (cANA) containing antisense oligonucleotides (ASOs) was carried out to ascertain how conformationally restricting the D-altritol backbone-containing ASO (Me-ANA) would affect their ability to form duplexes with RNA. It was found that the thermal stability was reduced (cANA/RNA -1.1 °C/modification) compared to DNA/RNA, suggesting the constrained system results in a small destabilizing perturbation in the duplex structure.
Abstract 18489: Growth Hormone Releasing Hormone Agonist (GHRH-A) Restores Cardiac Function in a Rodent Model of Heart Failure With Preserved Ejection Fraction (HFpEF) (2017)

Introduction: Roughly half of patients with heart failure (HF) have preserved EF (HFpEF) and this rate is increasing. The pathophysiology of HFpEF is unclear and treatment of HFpEF remains a critic...
Bilayer induced diastereomeric kinetic differentiation (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBilayer induced diastereomeric kinetic differentiationRussell C. Petter, John C. Mitchell, William J. Brittain, Thomas J. McIntosh, and Ned A. PorterCite this: J. Am. Chem. Soc. 1983, 105, 17, 5700–5701Publication Date (Print):August 1, 1983Publication History Published online1 May 2002Published inissue 1 August 1983https://pubs.acs.org/doi/10.1021/ja00355a035https://doi.org/10.1021/ja00355a035research-articleACS PublicationsRequest reuse permissionsArticle Views54Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Circulating Vascular Endothelial Growth Factor Correlates with Systemic Thrombin Generation in Patients with Pancreatic Carcinoma (1999)

Circulating Vascular Endothelial Growth Factor Correlates with Systemic Thrombin Generation in Patients with Pancreatic Carcinoma -
Interaction Between Peroxisome Proliferator Activated Receptor δ and Epithelial Membrane Protein 2 Polymorphisms Influences HDL‐C Levels in the Chinese Population (2016)

Peroxisome proliferator activated receptors (PPARs) are transcription factors involved in the regulation of key metabolic pathways. Numerous in vivo and in vitro studies have established their important roles in lipid metabolism. A few SNPs in PPAR genes have been reported to be associated with lipid levels. In this study, we aimed to investigate the interactive effects between single nucleotide polymorphisms (SNPs) in three PPAR isoforms α/δ/γ and other genetic variants across the genome on plasma high-density lipoprotein-cholesterol (HDL-C) levels. Study subjects (N = 2003) were genotyped using Illumina HumanOmniZhongHua-8 Beadchip. Fifty-three tag SNPs ± 100 kb of PPAR α, δ, and γ (r(2) < 0.2) were selected. The effect of interactions between PPAR SNPs and those across the genome on HDL-C was tested using linear regression models. One statistically significant interaction influencing HDL-C was detected between PPARδ SNP rs2267668 and epithelial membrane protein 2 (EMP2) downstream SNP rs7191411 (N = 1993, β = 0.74, adjusted P = 0.022). This interaction was successfully replicated in the meta-analysis of two additional Chinese cohorts (N = 3948, P = 0.01). The present study showed a novel SNP × SNP interaction between rs2267668 in PPARδ and rs7191411 in EMP2 that has significant impact on circulating HDL-C levels in the Singaporean Chinese population.
"Discovery and Development of an Oral, Small Molecule PCSK9/LDLR Antagonist" (2021)

Dyslipidemia contributes to the development of atherosclerosis, an inflammatory condition resulting from multiple and cumulative risk factors, each of which contributes in varying ways to the development and severity of the condition
High-brightness slab-coupled optical waveguide lasers (2007)

We have been developing a high power, high brightness semiconductor diode laser concept, the Slab-Coupled Optical Waveguide Laser (SCOWL). This laser concept is based upon slab coupling, in which a large, multimode waveguide is converted to a large, single mode waveguide by means of slab coupling of the higher order waveguide modes. SCOWL devices feature large, nearly circular mode sizes (&ap;4 x 4 &mgr;m and larger) and low modal loss, leading to low gain per unit length, allowing for the construction of long (&ap;1 cm cavity length) devices. These characteristics allow for high single mode output power. For 980-nm AlGaAs/InGaAs/GaAs-based SCOWL devices, we have demonstrated > 1 W CW output power in a single spatial mode, with brightness levels of > 100 MW/cm<sup>2</sup>-str. We have constructed high power arrays of SCOWL devices with bar widths of 1 cm and cavity lengths of 3 mm, and have demonstrated > 90 W under CW operation. By using the technique of wavelength beam combining (WBC), which is analogous to wavelength division multiplexing in optical communications, we have been able to combine the outputs from the elements of a SCOWL array to obtain 50 W peak power (30 W CW) with nearly diffraction-limited beam quality. These SCOWL arrays combined by WBC have demonstrated record single bar brightness levels, 3.6 GW/cm<sup>2</sup>- str. The WBC SCOWL approach is inherently scalable, and offers a route to obtaining kW-class, nearly diffraction limited output from an all-diode laser source. We have also recently extended single SCOWL devices to the multi-Watt regime, demonstrating 2.8 W CW output power from a 980-nm SCOWL with a novel design.
Why Size Matters: Feature Coding as Nystrom Sampling (2013)

Recently, the computer vision and machine learning community has been in favor of feature extraction pipelines that rely on a coding step followed by a linear classifier, due to their overall simplicity, well understood properties of linear classifiers, and their computational efficiency. In this paper we propose a novel view of this pipeline based on kernel methods and Nystrom sampling. In particular, we focus on the coding of a data point with a local representation based on a dictionary with fewer elements than the number of data points, and view it as an approximation to the actual function that would compute pair-wise similarity to all data points (often too many to compute in practice), followed by a Nystrom sampling step to select a subset of all data points. Furthermore, since bounds are known on the approximation power of Nystrom sampling as a function of how many samples (i.e. dictionary size) we consider, we can derive bounds on the approximation of the exact (but expensive to compute) kernel matrix, and use it as a proxy to predict accuracy as a function of the dictionary size, which has been observed to increase but also to saturate as we increase its size. This model may help explaining the positive effect of the codebook size and justifying the need to stack more layers (often referred to as deep learning), as flat models empirically saturate as we add more complexity.
Developing novel therapeutic strategies through biological effects of ultrasound (2006)

Ultrasound-mediated cavitation has been shown to facilitate delivery of drugs across biological barriers in cells and tissues. However, these nonthermal mechanisms can also trigger various biochemical pathways in the biological milieu, opening up doors to interesting ultrasonic therapeutic applications. For example, a brief application of ultrasound followed by treatment with quercetin (a poorly potent chemotherapeutic drug) becomes selectively cytotoxic towards prostate and skin cancer cells. As opposed to the increased delivery of drugs to cancer cells, this treatment methodology is hypothesized to be mediated through inhibition of heat shock protein-hsp72, a vital stress-protein essential for the survival of cancer cells. Additional examples demonstrating the use of ultrasound’s biological effects for therapeutic applications will be discussed. For example, ultrasound is demonstrated to work as a vaccination adjuvant by activating the Langerhans cells (immune cells present in skin) and leading to a robust immune response against tetanus toxoid. Overall, this presentation will demonstrate the increasing importance of ultrasound’s role as a biological sensitizer enabling novel therapeutic strategies, a role which is beyond its conventional use as a drug delivery tool.
Hydrogen-bonded ferroelectric liquid-crystalline complexes based on a chiral benzoic acid and stilbazoles. induction of chiral smectic C phases by molecular self-assembly (1993)

Abstract Hydrogen-bonded ferroelectric liquid-crystalline complexes have been obtained by self-assembly of S-(+)-4-(2-methylbutoxy)benzoic acid and trans-4-alkoxy-4'-stilbazoles. Chiral smectic C phases are induced by the formation of the hydrogen bonds between the chiral nonmesogenic benzoic acid and the achiral stilbazoles. The chiral smectic C phase of the complex has been characterized by X-ray measurement. The hydrogen-bonded complex shows stable ferroelectric behavior in electric fields.
Trace-based load characterization for generating performance software models (1999)

Performance models of software designs can give early warnings of problems such as resource saturation or excessive delays. However models are seldom used because of the considerable effort needed to construct them. The ANGIOTRACE/sup TM/ was developed to gather the necessary information from an executable design and develop a model in an automated fashion. It applies to distributed and concurrent software with synchronous (send-reply or RPC) communications, developing a layered queuing network model. The trace-based load characterization (TLC) technique presented here extends the ANGIOTRACE/sup TM/ to handle software with both synchronous and asynchronous interactions. TLC also detects interactions which are effectively synchronous or partly-synchronous (forwarding) but are built up from asynchronous messages. These patterns occur in telephony software and in other systems. The TLC technique can be applied throughout the software life-cycle, even after deployment.
64MeV Proton single-event evaluation of Xilinx Single Event Mitigation (XilSEM) firmware on 7nm Versal™ ACAP devices (2022)

This paper presents the single-event upset (SEU) response of the Xilinx Soft Error Mitigation (XilSEM) firmware as applied to 7nm Versal ACAP. Migrated from the soft SEM IP, XilSEM is a firmware solution run on the platform management controller (PMC) to detect and correct single event upsets (SEU) in configuration memory (CRAM) of 7nm AMD-Xilinx FPGAs. Moreover, XilSEM also scans and detects any corruptions in 7nm Versal Network-on-chip Peripheral Interface (NPI) configuration bits. Data obtained from accelerated test using a 64MeV monoenergetic proton source is compared to control static readback test data in order to evaluate the XilSEM capability to detect and correct SEU. Results show that 100% of events are detected and zero XilSEM SEFIs are observed in Proton environment.
WHEN IS A CATEGORY OF MANY-SORTED ALGEBRAS CARTESIAN CLOSED? (1992)

The category of all S-sorted Σ-algebras is Cartesian closed iff all the operation symbols in Σ are strictly unary.
<title>Optical fiber sensor for the detection of laser-generated ultrasound in arterial tissues</title> (1995)

Theoretical and experimental aspects of an extrinsic Fabry-Perot optical fiber ultrasound sensor for use in a photoacoustic-guided laser angioplasty system are described. The sensor has been characterized using laser generated thermoelastic waves as a source of wideband ultrasound. A system sensitivity of 25 mV/MPa and an acoustic noise floor of 2 Pa/Hz<SUP>1/2</SUP> are reported using a transparent polymer film as the sensing element. The system demonstrates the required bandwidth for sensing thermoelastic waves containing frequency components up to 20 MHz.
A novel IEC propulsion unit for satellite applications (1996)

An innovative electrostatic ion thruster design, based on inertial electrostatic confinement (IEC) technology, is proposed for use as a 500–800‐W satellite thruster. The IEC thruster employs a spherical configuration, wherein ions are generated and accelerated towards the center of a spherical vacuum chamber. Virtual cathode formation in a high‐density central core region, combined with a locally distorted cathode grid potential field, extracts accelerated ions in an intense quasi‐neutral ion jet. Other than the jet formation, the IEC thruster is quite analogous to a planar electrostatic ion thruster ‘‘folded’’ into spherical form. Projected advantages of the IEC thruster include competitive efficiency, compactness, low‐weight, and durability.
Wide-Sense Estimation on the Special Orthogonal Group (2008)

In this paper we consider a simple estimation problem on the special orthogonal group SO(n) and indicate a possible way to construct approximate filters which is much in the same spirit of the "wide sense" approach to linear filtering theory. Our interest is mainly motivated by applications to computer vision.
Doppler effects of a light source on a metamaterial slab: a rigorous Green's function approach (2008)

We apply a (rigorous) Green's function theory to study the Doppler effects of a light source placed on top of a metamaterial slab. When the receiver is in motion with the source and the slab, we find that, in addition to a conventional Doppler mode, there are several other frequency components that do not obey the standard frequency-shift rule. We show that such new effects are caused by the coupling between the radiated electromagnetic waves and the surface modes of the metamaterial slab, whose dispersion relation varies as a function of velocity in the moving reference frame.
Discharge model of the grid-collector region during “ (1997)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Bernard Wernsman, Mohamed S. El-Genk; Discharge model of the grid-collector region during "slow quenching" of a Cs-Ba tacitron: Preliminary results. AIP Conference Proceedings 10 January 1997; 387 (1): 1609–1612. https://doi.org/10.1063/1.51984 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Array processing in correlated noise fields using instrumental variables and subspace fitting (2003)

An improved technique for direction-of-arrival estimation of temporally correlated signals in the presence of spatially colored, but temporally uncorrelated, noise is presented. The method is particularly suited to applications in which the receiver bandwidth exceeds that of the emitter signals. A statistical performance analysis shows that the method nearly achieves the deterministic Cramer-Rao bound if the signals are sufficiently predictable. A Monte Carlo experiment suggests that the theoretical estimation error variance well predicts the empirical mean square error down to the threshold region.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Cellulite: Is there a role for injectables? (2005)

Until further studies are performed, patients considering mesotherapy for cellulite must be aware that the substances currently being injected to treat this cosmetically disturbing, but medically benign, condition have not been thoroughly evaluated for safety or efficacy.