gebhart/patrepeval huggingface dataset:
Alkane dehydrogenation catalyzed by rhodium(I) phosphine complexes: observation of the stoichiometric alkane-to-rhodium hydrogen-transfer step (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkane dehydrogenation catalyzed by rhodium(I) phosphine complexes: observation of the stoichiometric alkane-to-rhodium hydrogen-transfer stepKuo Chen Shih and Alan S. GoldmanCite this: Organometallics 1993, 12, 9, 3390–3392Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/om00033a005https://doi.org/10.1021/om00033a005research-articleACS PublicationsRequest reuse permissionsArticle Views373Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Efficacy of gallium maltolate againstLawsonia intracellularisinfection in a rabbit model (2014)

Antimicrobial efficacy against Lawsonia intracellularis is difficult to evaluate in vitro, thus, the effects of gallium maltolate's (GaM) were investigated in a rabbit model for equine proliferative enteropathy (EPE). Juvenile (5-6-week-old) does were infected with 3.0 × 10(8) L. intracellularis/rabbit and allocated into three groups (n = 8). One week postinfection, one group was treated with GaM, 50 mg/kg; one, with doxycycline, 5 mg/kg; and one with a sham-treatment (control). Feces and blood were collected daily and weekly, respectively, to verify presence of L. intracellularis fecal shedding using qPCR, and seroconversion using immunoperoxidase monolayer assay. Rabbits were sacrificed after 1 week of treatment to collect intestinal tissues focusing on EPE-affected sections. Intestinal lesions were confirmed via immunohistochemistry. No difference was noted between treatments regarding EPE-lesions in jejunum (P = 0.51), ileum (P = 0.74), and cecum (P = 0.35), or in L. intracellularis fecal shedding (P = 0.64). GaM and doxycycline appear to have similar efficacy against EPE in infected rabbits.
Location of Immunization and Interferon-γ Are Central to Induction of Salivary Gland Dysfunction in Ro60 Peptide Immunized Model of Sjögren's Syndrome (2011)

Effective induction of salivary gland dysfunction after Ro60 peptide immunization depended on the site of injection. Disease induction was not affected by changing the immunization conditions. However, of interest is that the mechanism of action of Ro60 peptide immunization appears to involve an increase in Th1 cytokines, resulting in the induction of SG dysfunction.
Asymptotic Analysis for Spectrum-Sharing Systems With TAS/MRC Using Extreme Value Theory: An Overlooked Aspect (2019)

We investigate the asymptotic behavior for an overlooked aspect of spectrum-sharing systems when the number of transmit antennas nt at the secondary transmitter (ST) grows to infinity. Considering imperfect channel state information (CSI), we apply the transmit antenna selection and the maximal-ratio combining techniques at the ST and the secondary receiver (SR), respectively. First, we obtain the signalto-noise ratio (SNR) distributions received by the SR under perfect and imperfect CSI conditions. Then we show that the SNR distributions are tail-equivalent in the sense that the right tails of the two distributions decay in the same rate as the number of transmit antennas nt grows to infinity. Based on the extreme value theory, when the transmit power of the ST is solely limited by the interference constraint, we show that the limiting SNR at the SR is Fréchet-distributed and the limiting rate scales as log(n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> ). When the transmit power of ST is determined by both the maximal transmit power and the interference power constraints, the limiting SNR is Gumbel-distributed and the limiting rate scales as log(log(n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> )). We further show that the average rate can be estimated by the corresponding easier-to-obtain outage rate. Numerical results indicate that the derived asymptotic rate expressions represent accurate approximations even when nt is “not-solarge”. Finally, we study the robustness of the secondary transmissions by analyzing the corresponding average symbol error rates (SER) under general modulation and coding schemes. The findings indicate that the SER is Weibull distributed, when the maximal transmit power and interference power constraints are comparable.
(VS-121)FACE DISCRIMINATION AND READING SPEED TESTED WITH SIMULATED PROSTHETIC VISION (2000)

Dagnelie, Gislin PhD1; Thompson, Robert W. MD2; Humayun, Mark S. MD, PhD2 Author Information
A bounded uncertainty approach to multi-robot localization (2004)

We offer a new approach to the multi-robot localization problem. Using an unknown-but-bounded model for sensor error, we are able to define convex polytopes in the configuration space of the robot team that represent the set of configurations consistent with all sensor measurements. Estimates for the uncertainty in various parameters of the team's configuration such as the absolute position of a single robot, or the relative positions of two or more nodes can be obtained by projecting this polytope onto appropriately chosen subspaces of the configuration space. We propose a novel approach to approximating these projections using linear programming techniques. The approach can handle both bearing and range measurements with a computational complexity scaling polynomially in the number of roots. Finally, the workload is readily distributed - requiring only the communication of sensor measurements between robots. We provide simulation results for this approach implemented on a multi-robot team.
Activation of Host-NLRP3 Inflammasome in Myeloid Cells Dictates Response to Anti-PD-1 Therapy in Metastatic Breast Cancers (2022)

Tumor-associated inflammation leads to dysregulated cytokine production that promotes tumor immune evasion and anti-tumor immunity dysfunction. In advanced stage breast cancer, the proinflammatory cytokine IL-1β is overexpressed due to large proportions of activated myeloid cells in the tumor microenvironment (TME). Here, we demonstrate the role of the host nucleotide-binding domain, leucine-rich containing family, pyrin domain-containing 3 (NLRP3) inflammasome in metastatic breast cancer. In vitro, we show that stimulation of THP-1 cells with conditioned media collected from MDA-MB-468 cells induced NLRP3 activation and increased Pdcd1l1 expression. In vivo, mice deficient in NLRP3 orthotopically implanted with metastatic breast cancer cell line (E0771) showed significant reduction in tumor growth (p < 0.05) and increased survival (p < 0.01). Inhibition of NLRP3 with the small molecule OLT1177® reduced expression of Pdcd1l1 (p < 0.001), Casp1 (p < 0.01) and Il1b (p < 0.01) in primary tumors. Furthermore, tumor-bearing mice receiving OLT1177® showed reduced infiltration of myeloid-derived suppressor cells (MDSCs) (p < 0.001) and increased CD8+ T cells (p < 0.05) and NK cells (p < 0.05) in the TME. NLRP3 inhibition in addition to anti-PD-1 treatment significantly reduced tumor growth from the monotherapies (p < 0.05). These data define NLRP3 activation as a key driver of immune suppression in metastatic breast cancers. Furthermore, this study suggests NLRP3 as a valid target to increase efficacy of immunotherapy with checkpoint inhibitor in metastatic breast cancers.
Data Supplement from Comprehensive Biomarker Analysis and Final Efficacy Results of Sorafenib in the BATTLE Trial (2023)

&lt;p&gt;Supplementary Table 4. Eight-week disease control rates by EGFR mutation status stratified by ECOG performance status (4a) and by the number of prior lines of therapy before inclusion in the trial (4b).&lt;/p&gt;
An Electronic Prosthesis Mimicking the Dynamic Vestibular Function (2006)

This paper presents a functional architecture, system level design, and electronic evaluation of a unilateral vestibular prosthesis. The sensing unit of the prosthesis is a custom-designed one-axis micro-electromechanical system (MEMS) gyroscope. Similar to the natural semicircular canal, the MEMS gyroscope senses angular motion of the head and generates voltages proportional to the corresponding angular acceleration. The voltage is then converted into electric current pulses according to the physiological data relating angular acceleration to the spike count in the vestibular nerve. The current pulses can be delivered to stimulate the corresponding vestibular nerve branch. Electronic properties of the vestibular prosthesis prototype have been systematically evaluated and found to meet the design specifications. A unique feature of the present vestibular implant prototype is the scalability: the sensing unit, pulse generator, and the current source can be potentially implemented on a single chip using integrated MEMS technology.
Towards strong-field interactions with phase-controlled few-cycle light (2001)

The evolution of the carrier-envelope phase was fully electronically controlled in a train of sub-6-fs pulses and characterized for a train of sub-5-fs pulses. Optical waveform synthesis will soon enable the control of strong field nonlinear interactions on a time scale shorter than the optical cycle.
Role of the Hydrophobic Moiety of Tumor Promoters. Synthesis and Activity of 9-Alkylated Benzolactams. (1996)

(-)-Benzolactam-V8-310 reproduces the active conformation and biological activity of teleocidins. Various sizes and shapes of alkyl groups on aromatic nucleus of BL-V8 were synthesized as optically pure forms. Structure-activity results indicate that hydrophobic substituents at C-9 position plays a critical role for the appearance of biological activities.
Protein Crystallization by Combining Laser Irradiation and Solution-Stirring Techniques (2005)

Bovine adenosine deaminase in the absence of an inhibitor (free-ADA) does not form crystals when using conventional crystallization methods. Using a solution-stirring technique, we recently succeeded in generating a small number of free-ADA crystals. In this paper, we demonstrate the combination of laser-irradiated growth and stirring (COLAS). This technique was found to be useful for controlling crystal nucleation and growth, which led to the production of a much larger number of high-quality free-ADA crystals.
Robust Transmission in Downlink Multiuser MISO Systems: A Rate-Splitting Approach (2016)

We consider a downlink multiuser MISO system with bounded errors in the channel state information at the transmitter (CSIT). We first look at the robust design problem of achieving max-min fairness amongst users (in the worst-case sense). Contrary to the conventional approach adopted in literature, we propose a rather unorthodox design based on a rate-splitting (RS) strategy. Each user's message is split into two parts, a common part and a private part. All common parts are packed into one super common message encoded using a public codebook, while private parts are independently encoded. The resulting symbol streams are linearly precoded and simultaneously transmitted, and each receiver retrieves its intended message by decoding both the common stream and its corresponding private stream. For CSIT uncertainty regions that scale with SNR (e.g., by scaling the number of feedback bits), we prove that a RS-based design achieves higher max-min (symmetric) degrees of freedom (DoF) compared with conventional designs (NoRS). For the special case of nonscaling CSIT (e.g., fixed number of feedback bits), and contrary to NoRS, RS can achieve a nonsaturating max-min rate. We propose a robust algorithm based on the cutting-set method coupled with the weighted minimum mean-square error (WMMSE) approach, and we demonstrate its performance gains over state-of-the-art designs. Finally, we extend the RS strategy to address the quality of service (QoS) constrained power minimization problem, and we demonstrate significant gains over NoRS-based designs.
Antiviral Activity of HIV gp120-Targeting Bispecific T Cell Engager Antibody Constructs (2018)

Today's gold standard in HIV therapy is combined antiretroviral therapy (cART). It requires strict adherence by patients and lifelong medication, which can lower the viral load below detection limits and prevent HIV-associated immunodeficiency but cannot cure patients. The bispecific T cell-engaging (BiTE) antibody technology has demonstrated long-term relapse-free outcomes in patients with relapsed and refractory acute lymphocytic leukemia. Here, we generated BiTE antibody constructs that target the HIV-1 envelope protein gp120 (HIV gp120) using either the scFv B12 or VRC01, the first two extracellular domains (1 + 2) of human CD4 alone or joined to the single chain variable fragment (scFv) of the antibody 17b fused to an anti-human CD3ε scFv. These engineered human BiTE antibody constructs showed engagement of T cells for redirected lysis of HIV gp120-transfected CHO cells. Furthermore, they substantially inhibited HIV-1 replication in peripheral blood mononuclear cells (PBMCs) as well as in macrophages cocultured with autologous CD8<sup>+</sup> T cells, the most potent being the human CD4(1 + 2) BiTE [termed CD(1 + 2) h BiTE] antibody construct and the CD4(1 + 2)L17b BiTE antibody construct. The CD4(1 + 2) h BiTE antibody construct promoted HIV infection of human CD4<sup>-</sup>/CD8<sup>+</sup> T cells. In contrast, the neutralizing B12 and the VRC01 BiTE antibody constructs, as well as the CD4(1 + 2)L17b BiTE antibody construct, did not. Thus, BiTE antibody constructs targeting HIV gp120 are very promising for constraining HIV and warrant further development as novel antiviral therapy with curative potential.<b>IMPORTANCE</b> HIV is a chronic infection well controlled with the current cART. However, we lack a cure for HIV, and the HIV pandemic goes on. Here, we showed <i>in vitro</i> and <i>ex vivo</i> that a BiTE antibody construct targeting HIV gp120 resulted in substantially reduced HIV replication. In addition, these BiTE antibody constructs display efficient killing of gp120-expressing cells and inhibited replication in <i>ex vivo</i> HIV-infected PBMCs or macrophages. We believe that BiTE antibody constructs recognizing HIV gp120 could be a very valuable strategy for a cure of HIV in combination with cART and compounds which reverse latency.
Tanjungides A and B: New Antitumoral Bromoindole Derived Compounds from Diazona cf formosa. Isolation and Total Synthesis (2014)

Tanjungides A (1) (Z isomer) and B (2) (E isomer), two novel dibrominated indole enamides, have been isolated from the tunicate Diazona cf formosa. Their structures were determined by spectroscopic methods including HRMS, and extensive 1D and 2D NMR. The stereochemistry of the cyclised cystine present in both compounds was determined by Marfey's analysis after chemical degradation and hydrolysis. We also report the first total synthesis of these compounds using methyl 1H-indole-3-carboxylate as starting material and a linear sequence of 11 chemical steps. Tanjungides A and B exhibit significant cytotoxicity against human tumor cell lines.
Joint Pilot Design and Uplink Power Allocation in Multi-Cell Massive MIMO Systems (2018)

This paper considers pilot design to mitigate pilot contamination and provide good service for everyone in multi-cell massive multiple-input-multiple-output systems. Instead of modeling the pilot design as a combinatorial assignment problem, as in prior works, we express the pilot signals using a pilot basis and treat the associated power coefficients as continuous optimization variables. We compute a lower bound on the uplink capacity for Rayleigh fading channels with maximum ratio detection that applies with arbitrary pilot signals. We further formulate the max-min fairness problem under power budget constraints, with the pilot signals and data powers as optimization variables. Because this optimization problem is non-deterministic polynomial-time hard due to signomial constraints, we then propose an algorithm to obtain a local optimum with polynomial complexity. Our framework serves as a benchmark for pilot design in scenarios with either ideal or non-ideal hardware. Numerical results manifest that the proposed optimization algorithms are close to the optimal solution obtained by exhaustive search for different pilot assignments and the new pilot structure and optimization bring large gains over the state-of-the-art suboptimal pilot design.
Imidazo[1,2‐c]pyrimidin‐5(6H)‐one as a novel core of cyclin‐dependent kinase 2 inhibitors: Synthesis, activity measurement, docking, and quantum mechanical scoring (2018)

We report on the synthesis, activity testing, docking, and quantum mechanical scoring of novel imidazo[1,2-c]pyrimidin-5(6H)-one scaffold for cyclin-dependent kinase 2 (CDK2) inhibition. A series of 26 compounds substituted with aromatic moieties at position 8 has been tested in in vitro enzyme assays and shown to inhibit CDK2. 2D structure-activity relationships have ascertained that small substituents at position 8 (up to the size of naphtyl or methoxyphenyl) generally lead to single-digit micromolar IC<sub>50</sub> values, whereas bigger substituents (substituted biphenyls) decreased the compounds' activities. The binding modes of the compounds obtained using Glide docking have exhibited up to 2 hinge-region hydrogen bonds to CDK2 and differed in the orientation of the inhibitor core and the placement of the 8-substituents. Semiempirical quantum mechanics-based scoring identified probable favourable binding modes, which will serve for future structure-based design and synthetic optimization of substituents of the heterocyclic core. In summary, we have identified a novel core for CDK2 inhibition and will explore it further to increase the potencies of the compounds and also monitor selectivities against other protein kinases.
Additive Manufacturing of a y0-Tetragonal Uranium-Niobium Alloy (2018)

The ability to process near-net shape structures is of particular interest in applications using rare or expensive materials. Laser powder bed fusion additive manufacturing can meet this challenge, yet also introduces significant processing and materials challenges toward achieving structural integrity. Broadly addressed aspects affecting powder bed fusion structures include surface roughness, residual stresses, and porosity. Here, we focus on materials-specific challenges—namely, the influence of multiple pass reheating during processing and post-processing homogenization on phase transformations and the role of impurities and oxides on grain morphology and mechanical behavior—with a view of adopting laser powder bed fusion processing for the shape memory alloy, uranium-6 wt.% niobium. Our observations to date on the factors influencing material behavior and post-processing requirements and recommendations for process improvement are discussed herein.
A Novel Isoform of SK2 Assembles with Other SK Subunits in Mouse Brain (2005)

The SK2 subtype of small conductance Ca2+-activated K+ channels is widely distributed throughout the central nervous system and modulates neuronal excitability by contributing to the afterhyperpolarization that follows an action potential. Western blots of brain membrane proteins prepared from wild type and SK2-null mice reveal two isoforms of SK2, a 49-kDa band corresponding to the previously reported SK2 protein (SK2-S) and a novel 78-kDa form. Complementary DNA clones from brain and Western blots probed with an antibody specific for the longer form, SK2-L, identified the larger molecular weight isoform as an N-terminally extended SK2 protein. The N-terminal extension of SK2-L is cysteine-rich and mediates disulfide bond formation between SK2-L subunits or with heterologous proteins. Immunohistochemistry revealed that in brain SK2-L and SK2-S are expressed in similar but not identical patterns. Heterologous expression of SK2-L results in functional homomeric channels with Ca2+ sensitivity similar to that of SK2-S, consistent with their shared core and intracellular C-terminal domains. In contrast to the diffuse, uniform surface distribution of SK2-S, SK2-L channels cluster into sharply defined, distinct puncta suggesting that the extended cysteine-rich N-terminal domain mediates this process. Immunoprecipitations from transfected cells and mouse brain demonstrate that SK2-L co-assembles with the other SK subunits. Taken together, the results show that the SK2 gene encodes two subunit proteins and suggest that native SK2-L subunits may preferentially partition into heteromeric channel complexes with other SK subunits.
Development of anti-ageing natural products based on biodiversity of the Greek flora by employing environmentally friendly technologies and anti-ageing biological research (2015)

Ageing is a complex process driven by diverse molecular pathways and biochemical events. It has been defined as the time-dependent decline of functional capacity and stress resistance and affects most of tissues and organs of the body. The aim of this study is the development of anti-ageing natural products by employing state-of-the art environmentally friendly technologies and anti-ageing biological research. Specifically, a high number of plants (600) from Greek flora was selected and extracted by using “green technologies” (SFE, ASE and MWE). The extracts were investigated for their chemical profile and for their in vitro antioxidant activity (DPPH· and ABTS assays). Subsequently, the most promising extracts were applied to human diploid skin fibroblast cells and their antioxidant capacity was recorded by using the DCFH-DA assay. Based on these results 25 plant extracts were selected for further investigation. Assays were mainly based on normal human cells and refer to targets known to contribute cell protection from age-related damage. Specifically, they were tested for their efficacy against UV protection, as well as for their ability to modulate the proteasome and/or the autophagy-lysosome pathways functionality. “Multi-functional” extracts that apart from exerting antioxidant activity, are also activating main cellular pathways were identified. Plants affording the most bioactive extracts were cultivated, in order to protect the Greek biodiversity, while their chemical profile and biological activity was afresh confirmed. Among others, Rosa damascena R. and Sideritis scardica L. preparations showed the ability to reduce the ROS levels (to 24% and 51% compare to the control, respectively), while at a non-toxic concentration induced the activation of the proteasome LLVY/β5 peptidase activity. Finally, the results of the aforementioned biological research revealed these extracts as promising anti-ageing agents for potential usage as cosmeceuticals.