gebhart/patrepeval huggingface dataset:
Selective DNA Delivery to Breast Cancer Cells (2000)

Abstract : The hypothesis of this research was that specific cell-binding proteins or peptides could be used to enhance (therapeutic) DNA delivery to breast carcinomas. This hypothesis was experimentally tested, with the following results: (1) Recombinant adenovirus type 7 penton base protein (Ad7PB) was shown to mediate DNA transfer into mammalian cells, when coupled to plasm id DNA via a bifunctional peptide linker. However, the efficiency of DNA transfer was poor. (2) Since CD40 is highly expressed on some breast carcinomas, we selected for CD40-binding peptides using phage display technology. When coupled to the surface of adenovirus vectors, these peptides dramatically enhanced virally-mediated gene delivery to CD40-positive murine and human cells. (3) Since alpha v beta 3 integrin is expressed in many breast carcinomas, we generated novel alpha v beta 3-binding proteins by the directed mutagenesis of a natural integrin-binding protein, the tenth fibronectin type III domain (FNfn10). A novel derivative of FNfn10 was identified and shown to bind with high affinity and specificity to purified alpha v beta 3 integrin. It also interacted with cell surface-expressed alpha v beta 3, as determined by flow cytometry, but did not bind detectably to other cell surface integrins. Overall, these experiments have provided important tools and insights that will enhance gene transfer to breast carcinomas.
Degenerative Spine Disease : Pathologic Findings in 985 Surgical Specimens (2005)

A number of pathologic changes have been reported in spinal surgery specimens. The frequency of many of these is not well defined. We retrospectively reviewed the histologic features of 985 extradural spinal surgery specimens. Of the cases, 1.6% were identified clinically as synovial cysts. In addition, synovial tissue was seen in another 5.3% of cases, often embedded within disk material. Neovascularization of disk tissue was present in 8.1% of cases, chondrocyte clusters in 18.3%, and calcium pyrophosphate crystals in 2.8%, predominantly within disk material. With the exception of crystal deposits, all of these changes were significantly more common in the lumbar spine. A better understanding of cell-based degenerative changes will become essential with increasing research into cell-based therapies for spinal disk disease. We report data on the frequency of different pathologic changes and describe synovial metaplasia as a reactive change not previously reported.
Circadian Secretion Pattern of Copeptin, the C-Terminal Vasopressin Precursor Fragment (2010)

Copeptin, the C-terminal peptide of provasopressin, is stoichiometrically released with arginine vasopressin (AVP). In contrast to AVP, it is stable ex vivo (1) and reflects the AVP system, as shown in diabetes insipidus or the syndrome of inappropriate antidiuretic hormone secretion(2). Copeptin is a reliable marker of severe stress, with increased concentrations found in cases of critical illness, sepsis, hemorrhagic shock, and stroke(2). The serum copeptin concentration is profoundly and immediately stimulated after myocardial infarction(3). The absence of such stimulation within the first hours after the onset of symptoms has recently been proposed as an important negative predictor for excluding the likelihood of infarction in patients with unspecific chest pain(3).

Any further use of the peptide as a marker critically depends on clear cutoffs between health and disease. To better characterize the diagnostic accuracy of …
Comparing automated and human ratings of photographic aesthetics (2011)

ACQUINE has made automated rating of photographic aesthetics available on the web. We compare the influence of various factors, such as color, sharpness, and contrast, on the ratings that it gives. We also compare results with those given by human judges.
3D shape from thermal patterns: investigation of projection parameters in simulation and experiment (2019)

Structured light projection techniques based on diffuse reflection are widely used for accurate, fast, contactless, and nondestructive optical 3D shape measurements. It cannot be utilized to measure uncooperative materials, i.e., materials with optical properties such as being glossy, transparent, absorbent, or translucent. Recently, it was shown that 3D reconstruction of an uncooperative object can be performed by a two-step process for each camera image pair. In the first step, the object absorbs a projected thermal pattern, e.g., in the long-wave infrared range. In the second step, after energy conversion, the object surface reemits light according to Planck’s law. Whereas the irradiation can be performed by a CO<sub>2</sub> laser at 10.6 &mu;m, the detection of the reemitted light can be carried out by mid-wave infrared (MWIR) cameras sensitive in the wavelength range between 3 and 5 &mu;m. In order to achieve accurate 3D results in a short measurement time, the projection parameters like radiation intensity and illumination time as well as the projection patterns have to be optimized depending on optical and thermal material properties (e.g., complex spectral refractive index, thermal conductivity, specific heat capacity, emissivity). Therefore, we have developed a simulation tool based on the Beer-Lambert law (for absorption of the irradiation) and on the heat diffusion equation (for the illumination-induced thermal pattern on the object surface). In this contribution, we present our simulation tool and several simulation results. We apply our tool to investigate the projection parameters and projection patterns for a given material and a specific total measurement time. Finally, we experimentally verify the theoretical results with our MWIR 3D sensor.
Phototoxicity of the fluorescent membrane dyes PKH2 and PKH26 on the human hematopoietic KG1a progenitor cell line (1999)

We present guidelines for the optimal use of these dyes by using a defined hardware configuration.
Purification of Boron Nitride Nanotubes (2014)

• Nitric acid treatment and thermal oxidation: • Remove significant amounts of amorphous and crystalline boron as well as any metallic precursor. • Some tubes damaged during the process. • Demonstrates evidence that centrifuging and filtering must precede any of above treatments in order to remove nanocages. • Out of the tested solvents, SDS seems to be the better candidate for suspension and isolation. • SDS leaves residue that seems to be capable of being washed away. • Centrifuging at 3000 rpm is not sufficient to separate the nanotubes from other non-tubular nanostructures. Introduction
An efficient visualization method for analyzing biometric data (2013)

We introduce a novel application for biometric data analysis. This technology can be used as part of a unique and systematic approach designed to augment existing processing chains. Our system provides image quality control and analysis capabilities. We show how analysis and efficient visualization are used as part of an automated process. The goal of this system is to provide a unified platform for the analysis of biometric images that reduce manual effort and increase the likelihood of a match being brought to an examiner’s attention from either a manual or lights-out application. We discuss the functionality of FeatureSCOPE&trade; which provides an efficient tool for feature analysis and quality control of biometric extracted features. Biometric databases must be checked for accuracy for a large volume of data attributes. Our solution accelerates review of features by a factor of up to 100 times. Review of qualitative results and cost reduction is shown by using efficient parallel visual review for quality control. Our process automatically sorts and filters features for examination, and packs these into a condensed view. An analyst can then rapidly page through screens of features and flag and annotate outliers as necessary.
Analysis of Cooperative Action generating Trajectory in a Golf Swing (2019)

In this study, we tried to analyze the relationship between cooperative action of golf swing and difference of swing trajectory. For extracting cooperative action from different swings, we conducted experiment of acquiring swing data. Subjects was an experienced golfer. In this experiment, subjects swung two types swing that differ the swing trajectory. We measured an experienced golfer’s swings by motion capture system (VICON). We built observance matrix from acquired positional data and we conducted singular value decomposition (SVD) on this observance matrix. By conducting SVD, we extracted cooperative action as some independent modes. Then, we compared cooperative action of different swing trajectory on main mode. As a result, we reached the following conclusion that we could indicate some independent modes generating trajectory.
Study of Si1−xGex/Si-MBE growth process by using anin-situellipsometric measurement (2002)

The structural investigation of AlInAs/GaAs superlattices has been performed using high resolution X-ray diffraction and X-ray reflectivity. The samples differing each other in the In content and in the number of bilayers were grown by MOCVD on GaAs (001) substrates with a miscut in the range from 0 to 3. The combination of the above mentioned X-ray techniques allows to characterise the morphology of interfaces. The system chosen provides us effects strong enough in both diffraction and reflection modes. The reciprocal space maps were obtained in both modes, in the diffraction one In reflections 004 and 002, always in various azimuths. The investigation revealed well-defined lateral periodicity of the interfaces. We suppose the interfaces are constituted from step-like objects, formed during growth through bunching of the miscut-induced monolayer steps on the substrate surface. The elementary cell of this twodimensional structure is a parallelogram. We compared the experimental results with theoretical calculations performed on the simple basis of coherent scattering by point centres lying at the interface. It follows from the results, that the shape of bunch steps depends strongly on the In concentration. This is in agreement with our experimental findings. For higher In concentration the misfit dislocations occur and relaxation takes place. The maxima of the resonance diffuse scattering appear in the reflection experiments and due to relaxation they are not observed in the diffraction mode.
Bis(pentamethylcyclopentadienyl)actinide alkyls: facile activation of carbon monoxide, carbon-carbon double bond formation, and the production of unusual oxygen-bonded migratory insertion products (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBis(pentamethylcyclopentadienyl)actinide alkyls: facile activation of carbon monoxide, carbon-carbon double bond formation, and the production of unusual oxygen-bonded migratory insertion productsJuan M. Manriquez, Paul J. Fagan, Tobin J. Marks, Cynthia Secaur Day, and Victor W. DayCite this: J. Am. Chem. Soc. 1978, 100, 22, 7112–7114Publication Date (Print):October 1, 1978Publication History Published online1 May 2002Published inissue 1 October 1978https://pubs.acs.org/doi/10.1021/ja00490a077https://doi.org/10.1021/ja00490a077research-articleACS PublicationsRequest reuse permissionsArticle Views417Altmetric-Citations97LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Human iPSC Neurons Display Activity-Dependent Neurotransmitter Secretion: Aberrant Catecholamine Levels in Schizophrenia Neurons (2014)

This study investigated human-induced pluripotent stem cell (hiPSC) -derived neurons for their ability to secrete neurotransmitters in an activity-dependent manner, the fundamental property required for chemical neurotransmission. Cultured hiPSC neurons showed KCl stimulation of activity-dependent secretion of catecholamines--dopamine (DA), norepinephrine (NE), and epinephrine (Epi)--and the peptide neurotransmitters dynorphin and enkephlain. hiPSC neurons express the biosynthetic enzymes for catecholamines and neuropeptides. Because altered neurotransmission contributes to schizophrenia (SZ), we compared SZ to control cultures of hiPSC neurons and found that SZ cases showed elevated levels of secreted DA, NE, and Epi. Consistent with increased catecholamines, the SZ neuronal cultures showed a higher percentage of tyrosine hydroxylase (TH)-positive neurons, the first enzymatic step for catecholamine biosynthesis. These findings show that hiPSC neurons possess the fundamental property of activity-dependent neurotransmitter secretion and can be advantageously utilized to examine regulation of neurotransmitter release related to brain disorders.
State of the art: Polymer chemistry. Introduction (1981)

ADVERTISEMENT RETURN TO ISSUEPREVEditorialNEXTState of the art: Polymer chemistry. IntroductionFrank W. Harris Cite this: J. Chem. Educ. 1981, 58, 11, 836Publication Date (Print):November 1, 1981Publication History Received3 August 2009Published online1 November 1981Published inissue 1 November 1981https://doi.org/10.1021/ed058p836RIGHTS & PERMISSIONSArticle Views477Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (732 KB) Get e-Alertsclose Get e-Alerts
Experimental evaluations of feasibility and bottlenecks of IP/sup 2/ mobility management (2005)

Experimental system of IP/sup 2/ mobility management was designed and implemented in order to confirm feasibility of the protocol and identify its bottlenecks. The experimental system is based on a prototype implementation of IP/sup 2/ mobility management which runs on PC servers. Series of experiments were conducted in order to check validity of protocol sequence and impact of load status on system performance. From the feasibility tests results, it was confirmed that there was no fundamental error in IP/sup 2/ mobility management and it could interwork with other IP protocols. Throughout the bottleneck tests, degradation in performance due to limitation of the transport: mechanism was observed when the MN had relatively large number of active peers. Experimental results indicated that alternate mechanism to improve reliability of signalling messages was highly needed. From user-plane viewpoint, additional processing that is specific to IP/sup 2/ mobility management put negligible effect on the packet forwarding delay of the AR.
Characterization of Gonadotropin-Releasing Hormone (GnRH) Binding to Pituitary Receptors in Goldfish (Carassius Auratus)1 (1987)

Goldfish pituitary gonadotropin-releasing hormone (GnRH) receptors were characterized by using a superagonist analog of teleost GnRH (tGnRH-A; [D-Arg6, Trp7, Leu8, Pro9-NHEt]-GnRH). Equilibrium binding of 125I-tGnRH-A to a goldfish pituitary membrane preparation was achieved after a 30-min incubation at 4 degrees C; binding was significantly reduced after increasing incubation temperature to 22 degrees C. Binding of the radioligand was a function of tissue concentration, with a linear correlation over the range of 0.5-2 pituitary per tube. Incubation of the pituitary membrane preparation with increasing concentrations of 125I-tGnRH-A indicated saturable binding at radioligand concentrations of 470 pM and above. The binding of 125I-tGnRH-A was found to be reversible after addition of the cold analog, and the dissociation curve could be resolved into two linear components; slower rates of dissociation of 125I-tGnRH-A were observed after the addition of excess unlabeled tGnRH than after the addition of tGnRH-A, indicating that the analog is more effective in displacing the label than the native peptide. Addition of the cold analog displaced bound 125I-GnRH-A, and Scatchard analysis suggested the presence of at least two classes of binding sites: a high-affinity/low-capacity site and a low-affinity/high-capacity site. Bound 125I-GnRH-A was displaced by tGnRH from both sites in parallel to that observed with tGnRH-A, indicating that both peptides bind to the same classes of binding sites; however, tGnRH-A had a greater affinity for the receptors than the native tGnRH. These results demonstrated the presence and provided characterization of GnRH receptors in goldfish pituitary.
12 W/mm recessed-gate AlGaN/GaN heterojunction field-plate FET (2004)

A recessed-gate structure was introduced to improve transconductance (gm) and gain characteristics in AlGaN/GaN field-plate (FP) FETs. A maximum gm was improved from 130 to 200 mS/mm by introducing gate recess. Recessed FP-FETs exhibited 3-7 dB higher linear gain as compared with planar FP-FETs. A 1 mm-wide recessed FP-FET biased at a drain voltage of 66 V demonstrated 12.0 W output power, 21.2 dB linear gain, and 48.8 % power added efficiency at 2 GHz. To our knowledge, the power density of 12.0 W/mm is the highest ever achieved for GaN-based FETs.
427 Manufacturing of Sandwich Panel with Porous Aluminum/Dense Steel Plate via Friction Stir Processing Route (2010)

Porous aluminum is a lightweight material with high energy absorption properties. In this study, porous aluminum / dense steel sandwich panel was fabricated by friction stir processing (FSP) route. It is expected that both mixing a blowing agent into aluminum and bonding the aluminum precursor to dense steel plate can be conducted simultaneously by FSP. It was shown that sandwich panel which had high interface strength with porosity of approximately 90% was successfully fabricated at a holding temperature of 1003 K and at a holding time of 14 min 30 sec.
Design, Synthesis, and Evaluation of Analogues of (+)-14-Normethyldiscodermolide (2004)

[Structure: see text] The design, syntheses, and biological evaluation of nine totally synthetic analogues of the microtubule-stabilizing agent (+)-14-normethyldiscodermolide (2) are reported. Simplification at the C(21)-C(24) terminal diene and at the C(1)-C(5) lactone moieties reveals significant structure-activity relationships.
Design Review Of A Unique Complete Angle Scatter Instrument (CASI) (1987)

A useful way to present scatter data is scattered light power density (dPs/dws) normalized by the incident light power and plotted as a function of angle from specular. Nicodemus pointed out that if this quantity is also normalized by the cosine of the angle between the surface normal and the direction of scatter (Os) that the resulting expression was the differential scattered radiance normalized by the incident irradiance[1]. This expression has become known as the bidirectional scattered (reflectance or transmission) distribution function (BSDF, BRDF or BTDF)[2].
Quasi one-dimensional confinement in double-well sidewall gated resonant tunneling transistors (1997)

In this paper we present gating effects in double well resonant tunneling heterostructures with sub-micron minimum feature widths. Resonant tunneling through one dimensional states in the wells is observed as the device approaches pinch-off at temperatures as high as 77 K. This is the first clear demonstration of resonant tunneling through such laterally confined one-dimensional sub-bands at 77 K.
Decode-compress and forward relay: AWGN and constellation constrained channels (2017)

Even though there exists a lot of different transmission techniques, the capacity of the general relay channel is still unknown. This paper shows that combining decode-and-forward (DF) with compress-and-forward (CF) can have a performance advantage over each of the two techniques individually. Combining the two techniques goes back to the celebrated work of Cover and El-Gamal [1], more specifically, they gave an achievable rate for the DF-CF combination. In this paper, we re-derive the achievable rate of combining DF with CF in the full-duplex discrete memoryless relay channel. We derive the achievable rate in the AWGN relay channel as well as the constrained constellation AWGN relay channel. We show that even though in the AWGN channel, DF-CF combination does not provide any advantage, under constrained constellation, combining the two techniques has an advantage.
Structure‐property relationships for styrene‐diene thermoplastic elastomers (1969)

Abstract A study has been carried out on block polymers of the A‐B‐A type, the thermoplastic elastomers, where A represents polystyrene and B polybutadiene or polyisoprene. The objective was to relate the mechanical properties of these elastomers to their molecular architecture. For this purpose a series of styrene‐butadiene and styrene‐isoprene block polymers were synthesized by means of organolithium initiators, in which the block lengths of the polystyrene and polydiene were varied. It was found that the stress‐strain properties of styrene‐butadiene polymers are mainly dependent on the polystyrene content, regardless of the block sizes, and that the center, elastic block does not appear to behave as the “molecular weight between crosslinks” of these networks. However, the monodispersity of the chain length of these elastic blocks does appear to contribute substantially to higher tensile strengths. The polystyrene appears to be aggregated in small domains, of the order of several hundred angstrom units, and these undergo an irreversible deformation under stress, which is, however, completely recoverable above the T g of the polystyrene. At high polystyrene contents (∼40%) these elastomers exhibit an irreversible yield point at very low elongations, and this is ascribed to the presence of a continuous phase of connected polystyrene domains, which can be re‐formed by raising the temperature above the T g of the polystyrene. Although the stress‐strain curves are not affected by the thermal history of the sample, the tensile strength, especially at high styrene contents, is strongly dependent on “annealing” of any frozen stresses in the polystyrene phase. The useful range of block molecular weights is about 10,000–20,000 for polystyrene and 40,000–80,000, respectively, for polybutadiene. The lower limit is probably governed by the minimum polystyrene chain length required to insure the formation of a heterogeneous phase; while the upper limit is set by the high viscosity of both blocks, which might seriously hamper domain formation.