gebhart/patrepeval huggingface dataset:
Elevated intracranial venous pressure as a universal mechanism in pseudotumor cerebri of varying etiologies (1996)

Pseudotumor cerebri (PTC), or idiopathic intracranial hypertension, is a syndrome associated with multiple clinical conditions. We hypothesize that most if not all etiologies result in an increase in intracranial venous pressure as a final common pathway. We studied 10 patients with PTC. Five had dural venous outflow obstruction as demonstrated by venography, and the five remaining patients had normal venous anatomy. Pressure measurements, made during venography in eight patients, all showed elevated pressures. Pressure measurements in the superior sagittal sinus ranged from 13 to 24 mm Hg (mean, 16.6 mm HG). Patients with obstruction tended to have a high pressure gradient across the stenotic segment. Five patients with normal dural venous anatomy had elevated right atrial pressures (range, 6 to 22 mm Hg; mean, 11.8 mm Hg), which were transmitted up to the intracranial venous sinuses. Endovascular techniques, including angioplasty and infusion of thrombolytic agents in some cases, improved outlet obstruction from a hemodynamic perspective but were ineffective in consistently and reliably alleviating the clinical manifestations of PTC. Patients in both groups tended to respond well to conventional CSF diversion procedures. Our study suggests that elevated intracranial venous pressure may be a universal mechanism in PTC of different etiologies. This elevated venous pressure leads to elevation in CSF and intracranial pressure by resisting CSF absorption. Although the mechanism leading to venous hypertension in the presence of outflow obstruction is obvious, the etiology of increased intracranial and central systemic venous pressure in PTC remains obscure.
Simultaneous bilateral choroidal neovascularization associated with Staphylococcus aureus infective endocarditis: A case report (2021)

The findings from this case highlight the importance of monitoring visual symptoms in patients with infective endocarditis. CNV can result in vision loss when it involves the macula; therefore, prompt diagnosis is important. Intravitreal anti-vascular endothelial growth factor injection can be an effective treatment in such cases. To the best of our knowledge, this is the first report of simultaneous bilateral CNV associated with infective endocarditis.
Novel S1P1 Receptor Agonists – Part 1: From Pyrazoles to Thiophenes (2013)

From a high-throughput screening campaign aiming at the identification of novel S1P1 receptor agonists, the pyrazole derivative 2 emerged as a hit structure. Medicinal chemistry efforts focused not only on improving the potency of the compound but in particular also on resolving its inherent instability issue. This led to the discovery of novel bicyclo[3.1.0]hexane fused thiophene derivatives. Compounds with high affinity and selectivity for S1P1 efficiently reducing the blood lymphocyte count in the rat were identified. For instance, compound 85 showed EC50 values of 7 and 2880 nM on S1P1 and S1P3, respectively, had favorable pharmacokinetic properties in rat and dog, distributed well into brain tissue, and efficiently and dose dependently reduced the blood lymphocyte count in the rat. After oral administration to spontaneously hypertensive rats, the S1P1 selective compound 85 showed no effect on mean arterial blood pressure and affected the heart rate during the wake phase of the animals only.
Designing youth mental health services for the 21st century: examples from Australia, Ireland and the UK (2013)

Despite the evidence showing that young people aged 12-25 years have the highest incidence and prevalence of mental illness across the lifespan, and bear a disproportionate share of the burden of disease associated with mental disorder, their access to mental health services is the poorest of all age groups. A major factor contributing to this poor access is the current design of our mental healthcare system, which is manifestly inadequate for the unique developmental and cultural needs of our young people. If we are to reduce the impact of mental disorder on this most vulnerable population group, transformational change and service redesign is necessary. Here, we present three recent and rapidly evolving service structures from Australia, Ireland and the UK that have each worked within their respective healthcare contexts to reorient existing services to provide youth-specific, evidence-based mental healthcare that is both accessible and acceptable to young people.
MEMS Lubrication by Tribochemical Reaction (2007)

A means of providing replenishable lubrication to rubbing silicon surfaces is demonstrated. Alcohol at a small fraction of saturation vapor pressure is introduced in a nitrogen environment. Pin-on-flat sliding experiments in this environment reveal a friction coefficient near 0.2, and absence of wear above a critical alcohol concentration. This lubrication approach was also demonstrated in microfabricated silicon machines, where the devices operated at least a factor of 104 longer without failure when alcohol vapor was present in the nitrogen gas environment, compared to devices in dry N2 with a chemisorbed monolayer alone. When water vapor was added to the environment, vapor lubrication by alcohol was inhibited at concentration ratios of water:alcohol = 2.5:1.
A Semantic Web Management Model for Integrative Biomedical Informatics (2008)

The Semantic Web technologies have the potential to addresses the need for distributed and evolvable representations that are critical for systems Biology and translational biomedical research. As this technology is incorporated into application development we can expect that both general purpose productivity software and domain specific software installed on our personal computers will become increasingly integrated with the relevant remote resources. In this scenario, the acquisition of a new dataset should automatically trigger the delegation of its analysis.
An XPS study of as-grown superconducting Bi-Sr-Ca-Cu-O thin film with Tc/sub 0/ of 98 K (1993)

As-grown highly oriented BiSrCaCuO 2223 single-phase films were prepared by three-target RF magnetron sputtering with a regulated shuttering technique. Using this technique, 2223 films (700 AA) were deposited on the 2201 buffer layer (70 AA) prepared on an MgO
Performance characteristics of phase-change integrated silicon nitride photonic devices in the O and C telecommunications bands (2020)

The evaluation and comparison of the optical properties in the O and C bands of silicon nitride rib waveguides with integrated Ge 2 Sb 2 Te 5 phase-change cells is reported. In straight rib waveguides, a high transmission contrast is observed in both bands when the Ge 2 Sb 2 Te 5 cell is switched between states, being up to 2.5 dB/ μ m in the C-band and 6.4 dB/ μ m in the O-band. In the case of silicon nitride ring resonator waveguides, high quality factor resonances ( Q ∼ 10 5 ) are found in both bands, leading to the provision of an ON-OFF switch characterized by an extinction ratio of 12 and 18 dB in O and C bands respectively. Finally, with the view to provide a comparison of the wavelength-dependent optical switching of the phase-change cell, a 3-dimensional finite-element method simulation is performed and a comparison of the optical-to-thermal energy conversion in both bands given.
Analysis and surface energy estimation of various model polymeric surfaces using contact angle hysteresis (2007)

Wetting of hydrophobic polymer surfaces commonly employed in electronic coatings and their interaction with surfactant-laden liquids and aqueous polymer solutions are analyzed using a contact angle hysteresis (CAH) approach developed by Chibowski and co-workers. In addition, a number of low surface tension acrylic monomer liquids, as well as common probe liquids are used to estimate solid surface energy of the coatings in order to facilitate a thorough analysis of surfactant effects in adhesion. Extensive literature data on contact angle hysteresis of surfactant-laden liquids on polymeric surfaces are available and are used here to estimate solid surface energy for further understanding and comparisons with the present experimental data. In certain cases, adhesion tension plots are utilized to interpret wetting of surfaces by surfactant and polymer solutions. Wetting of an ultra-hydrophobic surface with surfactant-laden liquids is also analyzed using the contact angle hysteresis method. Finally, a detailed analysis of the effect of probe liquid molecular structure on contact angle hysteresis is given using the detailed experiments of Timmons and Zisman on a hydrophobic self-assembled monolayer (SAM) surface. Hydrophobic surfaces used in the present experiments include an acetal resin [poly(oxymethylene), POM] surface, and silane, siloxane and fluoro-acrylic coatings. Model surfaces relevant to the literature data include paraffin wax, poly(methyl methacrylate) and a nano-textured surface. Based on the results, it is suggested that for practical coating applications in which surfactant-laden and acrylic formulations are considered, a preliminary evaluation and analysis of solid surface energy can be made using surfactant-laden probe liquids to tailor and ascertain the quality of the final coating.
Spherical Nucleic Acids with Tailored and Active Protein Coronae (2019)

Spherical nucleic acids (SNAs) are nanomaterials typically consisting of a nanoparticle core and a functional, dense, and highly oriented oligonucleotide shell with unusual biological properties that make them appealing for many applications, including sequence-specific gene silencing, mRNA quantification, and immunostimulation. When placed in biological fluids, SNAs readily interact with serum proteins, leading to the formation of ill-defined protein coronae on the surface, which can influence the targeting capabilities of the conjugate. In this work, SNAs were designed and synthesized with functional proteins, such as antibodies and serum albumin, deliberately adsorbed onto their surfaces. These particles exhibit increased resistance to protease degradation compared with native SNAs but still remain functional, as they can engage in hybridization with complementary oligonucleotides. SNAs with adsorbed targeting antibodies exhibit improved cellular selectivity within mixed cell populations. Similarly, SNAs coated with the dysopsonizing protein serum albumin show reduced macrophage uptake, providing a strategy for tailoring selective SNA delivery. Importantly, the protein coronae remain stable on the SNAs in human serum, exhibiting a less than 45% loss of protein through exchange after 12 h at 37 °C. Taken together, these results show that protein-SNA complexes and the method used to prepare them provide a new avenue for enhancing SNA stability, targeting, and biodistribution.
Measurements of second-order susceptibility at λ=1.5 μm in CdTe-based ternary alloys for efficient wavelength conversion (2000)

We have characterized the second-order optical nonlinear response of II-VI semiconductor ternary compounds Cd0.8Zn0.2Te and Cd0.78Mn0.22Te at λ=1.5 μm. A spectrally resolved phase-mismatch second-harmonic generation (SHG) technique has been used on bulk single crystals, exploiting 10−13 s optical pulses and multichannel detection. The nonlinear d coefficient has been measured and chromatic dispersion parameters have been validated. By normalizing SHG results in view of applications to all-optical wavelength conversion, the tested compounds prove to be interesting alternatives to more renowned AlxGa1−xAs.
Large Conductance, Calcium Activated Potassium (BK) Channels as New Therapeutic Target for Glioma (2013)

Gliomas are the most common malignant primary brain tumors that arise within the central nervous sys-tem in adults and they account for more than 80% of all brain tumors (Central Brain Tumor Registry of the United States [CBTRUS] http://www.cbtrus.org/). These tumors remain difficult to treat because of the infiltrative growth of the tumor cells, and their resist-ance to standard therapy. Glioblastoma Multiforme (WHO grade IV) is the most aggressive of the gliomas, accounts for nearly 60-70% of malignant gliomas. A common approach for the treatment of GBM involves surgery, radiation therapy, and various chemotherapeu-tic regimens [1,2]. Despite advance standard therapy, including surgical resection followed by radiation and chemotherapy, the prognosis for patients with GBM remains poor. Even patients who are optimally treated with combined multimodal treatments have a median survival of only 12 months. This is possibly because of the poor drug delivery and the correspondingly lim-ited therapeutic response caused by partly intact blood brain barrier (BBB) and blood-tumor barrier (BTB).
Expansion Mechanism of Cement Added with Expansive Additive (2003)

The model explaining the expansion mechanism of the cement added with an expansive additive is proposed on the basis of the measurement of autogenous volume change and the observation result of hydration products. It is inferred that the calcium hydroxide and ettringite generated from the expansive additive grow by entangling pores because the cement added with an expansive additive shows autogenous expansion while being accompanied by hydration shrinkage. It is suggests that calcium hydroxide forms on the surface of the expansive additive particles and ettringite on the surface of C3A and the expansive additive particles from the observation result of the hydration products. Based on these phenomena, the thickness of the hydration product layer was obtained by calculation. When a low addition-type expansive additive excellent in expansion property is used, chemical press effect is expected large compared with conventional expansive additives.
MEMS Tunable Mid-Infrared Plasmonic Spectrometer (2015)

We present a microelectromechanical systems (MEMS) tunable metamaterial, Fabry-Pérot interferometer with a widely tunable mid-infrared response. An array of subwavelength holes in a gold film is suspended above a gold reflector, forming an interferometer cavity whose length can be modulated over a range of 1.7 to 21.67 μm using MEMS electrostatic actuation. Reflectance spectra exhibit the convolution of extraordinary optical transmission through the holes and Fabry-Pérot resonances with free spectral ranges from 2900 to 230.7 cm–1. Measuring the free spectral range enables us to perform in situ interferometric calibration of the cavity length. We present a simple analytical model that describes the experimental and simulated results. This device shows promise as a surface-enhanced sensing substrate with a tunable spectral response.
Identification and Evaluations of Novel Insecticidal Proteins from Plants of the Class Polypodiopsida for Crop Protection against Key Lepidopteran Pests (2019)

Various lepidopteran insects are responsible for major crop losses worldwide. Although crop plant varieties developed to express <i>Bacillus thuringiensis</i> (Bt) proteins are effective at controlling damage from key lepidopteran pests, some insect populations have evolved to be insensitive to certain Bt proteins. Here, we report the discovery of a family of homologous proteins, two of which we have designated IPD083Aa and IPD083Cb, which are from <i>Adiantum spp</i>. Both proteins share no known peptide domains, sequence motifs, or signatures with other proteins. Transgenic soybean or corn plants expressing either IPD083Aa or IPD083Cb, respectively, show protection from feeding damage by several key pests under field conditions. The results from comparative studies with major Bt proteins currently deployed in transgenic crops indicate that the IPD083 proteins function by binding to different target sites. These results indicate that IPD083Aa and IPD083Cb can serve as alternatives to traditional Bt-based insect control traits with potential to counter insect resistance to Bt proteins.
Fréchet Audio Distance: A Metric for Evaluating Music Enhancement Algorithms (2018)

We propose the Fréchet Audio Distance (FAD), a novel, reference-free evaluation metric for music enhancement algorithms. We demonstrate how typical evaluation metrics for speech enhancement and blind source separation can fail to accurately measure the perceived effect of a wide variety of distortions. As an alternative, we propose adapting the Fréchet Inception Distance (FID) metric used to evaluate generative image models to the audio domain. FAD is validated using a wide variety of artificial distortions and is compared to the signal based metrics signal to distortion ratio (SDR), cosine distance and magnitude L2 distance. We show that, with a correlation coefficient of 0.52, FAD correlates more closely with human perception than either SDR, cosine distance or magnitude L2 distance, with correlation coefficients of 0.39, -0.15 and -0.01 respectively.
Supplementary Table 2 from Chemogenetic Evaluation of the Mitotic Kinesin CENP-E Reveals a Critical Role in Triple-Negative Breast Cancer (2023)

&lt;p&gt;PDF - 98K, Effect of PF-2771 on breast cell line proliferation and CIN index analysis.&lt;/p&gt;
Electro-optic sampling of 1.5-ps photoresponse signal from YBa2Cu3O7−δ thin films (1995)

Photoresponse signals with widths as short as 1.5 ps are observed from epitaxial YBa2Cu3O7−δ thin films using electro-optic sampling techniques. Voltage transients less than 2 ps wide are seen in 100- and 200-nm films exposed to 150-fs laser pulses and cooled to 79 K. At low bias currents, the amplitude of the fast response varies linearly with the bias current, suggesting a kinetic inductive mechanism. A negative transient about 15-ps long is also seen that may provide evidence for nonequilibrium recombination of excited quasiparticles into Cooper pairs. At high bias currents or large laser fluences, a fast tail with a decay time of about 10 ps appears in the response followed by a slow, resistive bolometric component due to sample heating. Nonequilibrium aspects of the photoresponse and the origin of the fast tail are discussed.
Block Copolymer Nanoparticles of Ethylene Oxide and Isobutyl Cyanoacrylate (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBlock Copolymer Nanoparticles of Ethylene Oxide and Isobutyl CyanoacrylateYoung Kweon Choi, You Han Bae, and Sung Wan KimCite this: Macromolecules 1995, 28, 24, 8419–8421Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/ma00128a062https://doi.org/10.1021/ma00128a062research-articleACS PublicationsRequest reuse permissionsArticle Views225Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Saliva oxytocin measures do not reflect peripheral plasma concentrations after intranasal oxytocin administration in men (2018)

Oxytocin plays an important role in social behavior. Thus, there has been significant research interest for the role of the oxytocin system in several psychiatric disorders, and the potential of intranasal oxytocin administration to treat social dysfunction. Measurement of oxytocin concentrations in saliva are sometimes used to approximate peripheral levels of oxytocin; however, the validity of this approach is unclear. In this study, saliva and plasma oxytocin was assessed after two doses of Exhalation Delivery System delivered intranasal oxytocin (8IU and 24IU), intravenous oxytocin (1IU) and placebo in a double-dummy, within-subjects design with men. We found that intranasal oxytocin (8IU and 24IU) administration increased saliva oxytocin concentrations in comparison to saliva oxytocin concentration levels after intravenous and placebo administration. Additionally, we found that saliva oxytocin concentrations were not significantly associated with plasma oxytocin concentrations after either intranasal or intravenous oxytocin administration. Altogether, we suggest that saliva oxytocin concentrations do not accurately index peripheral oxytocin after intranasal or intravenous oxytocin administration, at least in men. The data indicates that elevated oxytocin saliva levels after nasal delivery primarily reflect exogenous administered oxytocin that is cleared from the nasal cavity to the oropharynx, and is therefore a weak surrogate for peripheral blood measurements.
Solubilization of an Ionic Liquid, l-Butyl-3-methylimidazolium Hexafluorophosphate, in a Surfactant-Water System (2000)

Abstract The amphiphilic association structures were determined in the system; water, Laureth 4 (approximately C12(EO) 4), and the ionic liquid l-butyl-3-methylimidazolium hexafluorophosphate ([bmim[PF6]), using visual observation and small angle x-ray diffraction. The system showed a lamellar liquid crystal solubilizing the ionic liquid ([bmim[PF6]) to a maximum of 15%, an isotropic surfactant solution dissolving the ionic liquid to a maximum of 39%, an isotropic ionic liquid solution with less than 0.5% of water and surfactant and finally, an aqueous solution with only traces of surfactant and ionic liquid. The small angle x-ray diffraction results showed the ionic liquid to be solubilized into the lamellar liquid crystal without changing the dimensions of the amphiphile layer or the interlayer spacing dependence on the water content.