gebhart/patrepeval huggingface dataset:
125 – IMPACT OF SURGICAL WAITLIST TIMES ON SCOLIOSIS SURGERY: SURGEON’S PERSPECTIVE (2011)

Purpose: The wait for surgical treatment of scoliosis is long in some countries, especially in those with publicly funded health care systems. Long wait times may have serious consequences if the deformity increases during the wait period. This study was undertaken to determine the surgeon’s perspective of the type and magnitude of surgery required with specific emphasis on peri – and post-operative measures, for patients with scoliosis on prolonged waitlist times (>6 months) for surgery. Method: Radiographs from 11 patients who had a Cobb angle of at least 50 degrees and had waited 6 or more months for scoliosis surgery selected from the scoliosis database. All patients had antero-posterior (AP), AP bending, and lateral radiographs taken when the primary curve magnitude was 50 degrees and at the time of pre-operative planning. 22 radiographic sets and a questionnaire were sent to three different surgeons. The surgeons were blinded to the fact that these sets contained films of the same patients at two different time points. The questionnaire requested information with regard to the type of surgery and instrumentation they would use, other peri-operative measures, and time taken to return to normal activities. Results: The mean curve progression in the 11 patients was 25 degrees over the time on the waitlist, from an average of 50 degrees to 75 degrees. The type of surgery the surgeon would likely perform changed from posterior instrumentation and fusion with a screw construct in all patients to anterior release and posterior instrumentation and fusion with a screw construct in 8 of the 11 patients, in at least one surgeon’s opinion. The mean estimated operative time increased by 2 hours. The mean estimated length of stay at the hospital increased by 1 day, and the estimated level of difficulty of surgery increased from 3/10 to 5/10. Conclusion: From a surgeon’s perspective, waits of 6 months or more for scoliosis surgery are unacceptable as they lead to the need for a second anterior procedure that probably would have not been necessary had the operation occurred earlier. It also leads to increased operative time, blood loss, length of stay, and difficulty of surgery. This, in turn, increases unwarranted risks and costs.
CERAPP: Collaborative Estrogen Receptor Activity Prediction Project (2016)

Collaborative Estrogen Receptor Activity Prediction Project. Environ Health Perspect 124:1023-1033; http://dx.doi.org/10.1289/ehp.1510267.
Zn(II), Ni(II), Cu(II), and Fe(III) Complexes of Potentially Bimetalating Tris(pyridine- and imidazole-appended) Picket-Fence Naphthylporphyrins with Benzyl Ether Spacers:  Implications for Cytochrome c Oxidase Active-Site Modeling (2001)

Two new unsymmetrical picket-fence naphthylporphyrin ligands, 1 and 2, and several of their metalated porphyrinato complexes have been synthesized as precursor model compounds for the binuclear (Fe/Cu) cytochrome c oxidase (CcO) active site. 1 and 2 have a naphthylporphyrin superstructure that has been specifically incorporated to confer long-term configurational stability to the atropisomeric products. The two picket-fence porphyrin ligands also bear covalently linked, axially offset tris(heterocycle) coordination sites for a copper ion, much like that found in the native enzyme. Monometallic porphyrin complexes [M = Zn(II), Ni(II), Cu(II), and Fe(III)] of the pyridine-appended ligand 1 have been prepared and spectroscopically and magnetically characterized. An unusual monomeric iron(III) hydroxo porphyrin complex was isolated upon workup of the compound formed under ferrous sulfate/acetic acid reflux conditions. There is general difficulty in forming binuclear complexes of 1, which is attributed to the conformational flexibility of the benzyl ether type picket spacers. The potential of ligands such as 1 and 2 for future CcO active-site modeling studies is considered.
ChemInform Abstract: Polyhalogenoheterocyclic Compounds. Part 40. Tertiary Aromatic Amines as Carbon Nucleophiles with Activated Perfluorinated Aromatic Compounds. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Identification of sulfur components enhancing the anti-Candida effect of Lactobacillus rhamnosus Lcr35 (2020)

GYNOPHILUS (Lcr REGENERANS) is a live biotherapeutic product (LBP) aimed at restoring the vaginal microbiome and contains the live biotherapeutic microorganism Lactobacillus rhamnosus Lcr35. In this study, the LBP formulation and manufacturing process significantly enhanced the anti-Candida activity of L. rhamnosus Lcr35, with a complete loss of viability of the yeast after 48 h of coincubation. Sodium thiosulfate (STS), one excipient of the product, was used as a potentiator of the anti-Candida spp. activity of Lactobacilli. This contact-independent phenomenon induced fungal cell disturbances, as observed by electron microscopy observations. Nonverbal sensory experiments showed clear odor dissimilarities between cocultures of L. rhamnosus Lcr35 and C. albicans in the presence and absence of STS, suggesting an impact of odor-active metabolites. A volatolomic approach allowed the identification of six odor-active compounds, including one sulfur compound that was identified as S-methyl thioacetate (MTA). MTA was associated with the antifungal effect of Lcr35, and its functional link was established in vitro. We show for the first time that the LBP GYNOPHILUS, which is a highly active product in the reduction of vulvovaginal candidiasis, requires the presence of a sulfur compound to fully achieve its antifungal effect.
Telomerase activity in human nevi and melanomas (1997)

D'Atri, S; Pagani, E; Lacal, P M; Nunziata, C; Laurenza, M; Macchini, V; Baliva, G; Faraggiana, T; Passarelli, F; Atzori, F; Bonmassar, E; Shay, J W Author Information
Reduced endothelial thioredoxin‐interacting protein protects arteries from damage induced by metabolic stress in vivo (2018)

Although thioredoxin-interacting protein (TXNIP) is involved in a variety of biologic functions, the contribution of endothelial TXNIP has not been well defined. To investigate the endothelial function of TXNIP, we generated a TXNIP knockout mouse on the Cdh5-cre background (TXNIP<sup>fl/fl</sup> cdh5<sup>cre</sup>). Control (TXNIP<sup>fl/fl</sup>) and TXNIP<sup>fl/fl</sup> cdh5<sup>cre</sup> mice were fed a high protein-low carbohydrate (HP-LC) diet for 3 mo to induce metabolic stress. We found that TXNIP<sup>fl/fl</sup> and TXNIP<sup>fl/fl</sup> cdh5<sup>cre</sup> mice on an HP-LC diet displayed impaired glucose tolerance and dyslipidemia concretizing the metabolic stress induced. We evaluated the impact of this metabolic stress on mice with reduced endothelial TXNIP expression with regard to arterial structure and function. TXNIP<sup>fl/fl</sup> cdh5<sup>cre</sup> mice on an HP-LC diet exhibited less endothelial dysfunction than littermate mice on an HP-LC diet. These mice were protected from decreased aortic medial cell content, impaired aortic distensibility, and increased plasminogen activator inhibitor 1 secretion. This protective effect came with lower oxidative stress and lower inflammation, with a reduced NLRP3 inflammasome expression, leading to a decrease in cleaved IL-1β. We also show the major role of TXNIP in inflammation with a knockdown model, using a TXNIP-specific, small interfering RNA included in a lipoplex. These findings demonstrate a key role for endothelial TXNIP in arterial impairments induced by metabolic stress, making endothelial TXNIP a potential therapeutic target.-Bedarida, T., Domingues, A., Baron, S., Ferreira, C., Vibert, F., Cottart, C.-H., Paul, J.-L., Escriou, V., Bigey, P., Gaussem, P., Leguillier, T., Nivet-Antoine, V. Reduced endothelial thioredoxin-interacting protein protects arteries from damage induced by metabolic stress in vivo.
Effectiveness of cross-platform optimizations for a java just-in-time compiler (2003)

This paper describes the system overview of our Java Just-In-Time (JIT) compiler, which is the basis for the latest production version of IBM Java JIT compiler that supports a diversity of processor architectures including both 32-bit and 64-bit modes, CISC, RISC, and VLIW architectures. In particular, we focus on the design and evaluation of the cross-platform optimizations that are common across different architectures. We studied the effectiveness of each optimization by selectively disabling it in our JIT compiler on three different platforms: IA-32, IA-64, and PowerPC. Our detailed measurements allowed us to rank the optimizations in terms of the greatest performance improvements with the smallest compilation times. The identified set includes method inlining only for tiny methods, exception check eliminations using forward dataflow analysis and partial redundancy elimination, scalar replacement for instance and class fields using dataflow analysis, optimizations for type inclusion checks, and the elimination of merge points in the control flow graphs. These optimizations can achieve 90% of the peak performance for two industry-standard benchmark programs on these platforms with only 34% of the compilation time compared to the case for using all of the optimizations.
Quelques illustrations de l’utilisation durayonnement synchrotron pour la caractérisation du procédé sol-gel (1989)

Les procédés sol-gel mettent en jeu des réactions de polymérisation inorganique. Les gels sont des réseaux d’oxyde macromoléculaires obtenus à partir de précurseurs métallo-organiques (Ti(OR)4, VO(OR)3, WClx (OR)6-x ...) ou minéraux ([math], [math]) via des réactions d’hydroxylation et de condensation. L’optimisation des propriétés physiques des matériaux obtenus (gels, xérogels, poudres pour céramiques) nécessite la caractérisation poussée de toutes les étapes de synthèse allant du précurseur moléculaire au matériau. Cet article illustre l’utilisation du XANES, de l’EXAFS et de la DPAX pour la caractérisation de composés à base d’oxydes de métaux de transition (TiO2, v2o5, wo3).
Radiological sequelae in post tuberculosis patients treated at a tertiary care center in Pakistan: A retrospective study (2020)

<b>Background:</b> Tuberculosis (TB) is a major cause of morbidity and has a great socio-economic burden on the affected population not only during the ailment but even after the disease has been cured. Post TB sequelae continue to affect the lives of sufferers hence early recognition can facilitate the management. <b>Objectives:</b> To study the radiological sequelae in post TB patients and factors associated with it. <b>Methods:</b> Retrospective study on patients treated for TB at Aga Khan University Hospital, Pakistan from January 2014 to August 2017. <b>Results:</b> During the study period a total of 541 patients presented to outpatient pulmonology clinics with a mean age of 44 ±19 years. Post treatment chest x-rays were available in 321(59.3%) patients. Out of 321 patients, 82.8% (n=266) had some post TB radiological sequelae. The most frequent abnormalities were fibrocavitatory changes 56.3% (n=150), pleural thickening 30.8% (n=82) and loss of lung volume 12.7% (n=34). Out of 266 patients, 75.9% (n= 202) had unilateral while 24% (n=64) had bilateral abnormalities. The radiological sequelae were significantly high in patients who were AFB smear positive 80.9% (n=98/109), AFB culture positive 89.2% (n=125/140), those who had drug resistant TB 100% (n=21/21) and those who had diabetes mellitus 80.9% (n=34/42). <b>Conclusion:</b> Post-treatment radiological sequelae is very high in our treated TB patients. Treating tuberculosis is not the end of the disease. The comorbidities associated with post TB sequelae continues to cripple the life of the sufferers. Early intervention can reduce morbidity in these patients.
Modification of the Poly(bisdodecylquaterthiophene) Structure for High and Predominantly Nonionic Conductivity with Matched Dopants (2017)

Four p-type polymers were synthesized by modifying poly(bisdodecylquaterthiophene) (PQT12) to increase oxidizability by p-dopants. A sulfur atom is inserted between the thiophene rings and dodecyl chains, and/or 3,4-ethylenedioxy groups are appended to thiophene rings of PQT12. Doped with NOBF4, PQTS12 (with sulfur in side chains) shows a conductivity of 350 S cm<sup>-1</sup>, the highest reported nonionic conductivity among films made from dopant-polymer solutions. Doped with tetrafluorotetracyanoquinodimethane (F4TCNQ), PDTDE12 (with 3,4-ethylenedioxy groups on thiophene rings) shows a conductivity of 140 S cm<sup>-1</sup>. The converse combinations of polymer and dopant and formulations using a polymer with both the sulfur and ethylenedioxy modifications showed lower conductivities. The conductivities are stable in air without extrinsic ion contributions associated with PEDOT:PSS that cannot support sustained current or thermoelectric voltage. Efficient charge transfer, tighter π-π stacking, and strong intermolecular coupling are responsible for the conductivity. Values of nontransient Seebeck coefficient and conductivity agree with empirical modeling for materials with these levels of pure hole conductivity; the power factor compares favorably with prior p-type polymers made by the alternative process of immersion of polymer films into dopant solutions. Models and conductivities point to significant mobility increases induced by dopants on the order of 1-5 cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup>, supported by field-effect transistor studies of slightly doped samples. The thermal conductivities were in the range of 0.2-0.5 W m<sup>-1</sup> K<sup>-1</sup>, typical for conductive polymers. The results point to further enhancements that could be obtained by increasing doped polymer mobilities.
Molecular cloning and characterization of mitogen-activated protein kinase 2 inTrypanosoma cruzi (2010)

Mitogen-activated protein kinase (MAPK) pathways are major signal transduction systems by which eukaryotic cells convert environmental cues to intracellular events such as proliferation and differentiation. We have identified a Trypanosoma cruzi homologue of the MAPK family that we have called TcMAPK2. Sequence analyses demonstrates TcMAPK2 has high homology with lower eukaryotic ERK2 but has significant differences from mammalian ERK2. Enzymatic assays of both recombinant TcMAPK2 and native protein obtained by immunoprecipitation using anti-TcMAPK2 demonstrated that both preparations of TcMAPK2 were catalytically active. Immunofluorescence analysis of the subcellular localization of TcMAPK2 determined it is mainly cytoplasmic in epimastigotes, along the flagella in trypomastigotes and on the plasma membrane of intracellular amastigotes. Phosphorylated TcMAPK2 was highest in trypomastigotes and lowest in amastigotes. Recombinant TcMAPK2 was able to phosphorylate the recombinant protein of a cAMP specific phosphodiesterase. Over-expression of TcMAPK2 in epimastigotes inhibited growth and development leading to death. TcMAPK2 has an important role in the stress response of the parasite and may be important in regulating proliferation and differentiation.
Persuasive Evidence for Electron–Nuclear Coupling in Diluted Magnetic Colloidal Nanoplatelets Using Optically Detected Magnetic Resonance Spectroscopy (2019)

The incorporation of magnetic impurities into semiconductor nanocrystals with size confinement promotes enhanced spin exchange interaction between photogenerated carriers and the guest spins. This interaction stimulates new magneto-optical properties with significant advantages for emerging spin-based technologies. Here we observe and elaborate on carrier-guest interactions in magnetically doped colloidal nanoplatelets with the chemical formula CdSe/Cd<sub>1-<i>x</i></sub>Mn<sub><i>x</i></sub>S, explored by optically detected magnetic resonance and magneto-photoluminescence spectroscopy. The host matrix, with a quasi-type II electronic configuration, introduces a dominant interaction between a photogenerated electron and a magnetic dopant. Furthermore, the data convincingly presents the interaction between an electron and nuclear spins of the doped ions located at neighboring surroundings, with consequent influence on the carrier's spin relaxation time. The nuclear spin contribution by the magnetic dopants in colloidal nanoplatelets is considered here for the first time.
Automating ITSM Incident Management Process (2008)

Service desks are used by customers to report IT issues in enterprise systems. Most of these service requests are resolved by level-1 persons (service desk attendants) by providing information/quick-fix solutions to customers. For each service request, level- 1 personnel identify important keywords and see if the incoming request is similar to any historic incident. Otherwise, an incident ticket is created and, with other related information, forwarded to incident's subject matter expert (SME). Incident management process is used for managing the life cycle of all incidents. An organization spends lots of resources to keep its IT resources incident free and, therefore, timely resolution of incoming incident is required to attain that objective. Currently, the incident management process is largely manual, error prone and time consuming. In this paper, we use information integration techniques and machine learning to automate various processes in the incident management workflow. We give a method for correlating the incoming incident with configuration items (CIs) stored in Configuration management database (CMDB). Such a correlation can be used for correctly routing the incident to SMEs, incident investigation and root cause analysis. In our technique, we discover relevant CIs by exploiting the structured and unstructured information available in the incident ticket. We present efficient algorithm which gives more than 70% improvement in accuracy of identifying the failing component by efficiently browsing relationships among CIs.
TIME SERIES FROM THE ORDINAL VIEWPOINT (2007)

Ordinal time series analysis is a new approach to the investigation of long and complex time series, which bases on ordinal patterns describing the order relations between the values of a time series. In this paper we consider ordinal time series analysis from the conceptional viewpoint. In particular, we introduce ordinal processes as models for ordinal time series analysis and discuss the structure of ordinal pattern distributions obtained from them. Special emphasis is on the relation of ordinal time series analysis to symbolic dynamics and to a transformation extracting the whole ordinal information contained in a time series. Finally, we consider invariance properties of ordinal time series analysis.
Nonlocal competition and front propagation in branching-coalescence systems (2007)

The spatial invasion of a stable into an unstable phase is studied for the branching-coalescence process with nonlocal competition. Numerical experiments show that the threshold at the front leading edge, introduced by the discreteness of the reactants, allows for the nonlocal competition to affect the front velocity. However, the front still moves ballistically after a short transient period for any finite range competition length.
Optical bench simulation for intraocular lenses using field-tracing technology (2021)

The field-tracing optical bench simulation is a reliable method to evaluate IOL performance according to the IOL misalignment. It can provide retinal image quality close to real by taking into account the wave nature of light, interference and diffraction to explain to patients having the IOL misalignment.
System design of a pulsed laser rangefinder (1991)

A pulsed GaAs laser rangefinder is analyzed and designed. Expressions for background and signal power, noise, and signal-to-noise ratio are derived. The effects of pulse rise time, receiver bandwidth, and SNR on probability of detection and range accuracy are discussed. A computer simulation is used to optimize laser power, receiver aperture, and preamplifier bandwidth. A method ofthreshold detection is presented and discussed. Experimental results include receiver preamplifier transfer function and threshold detector performance.
Cross-layer resource allocation approach for multi-hop distributed cognitive radio network (2011)

In multi-hop distributed cognitive radio network, link layer resource allocation must consider the information about number of hops packets have already traveled in the network in order to optimize the overall resource utilization. The loss of a packet after traveling some hops results in waste of all the resources allocated to it in previous hops. The existing resource allocation schemes may not provide optimal resource utilization in such network as this issue has been greatly ignored. Therefore, in this paper, we propose a scheme to allocate transmit power to different packets favoring those which have traveled more hops before reaching a particular node. We present a cross-layer approach in which link layer gets the hop-count information from network layer module. Distributed implementation is possible with the proposed scheme because each node can access this information. We formulate the power allocation problem as a convex optimization problem and obtain its analytical solution by using Lagrangian duality. Simulation results show that the proposed scheme is capable of minimizing wastage of network resources used by packets in their previous hops without any degradation in throughput and outage performance.
Tumor-Immune Partitioning and Clustering (TIPC) algorithm reveals distinct signatures of tumor-immune cell interactions within the tumor microenvironment (2020)

Abstract Growing evidence supports the importance of understanding tumor-immune spatial relationship in the tumor microenvironment in order to achieve precision cancer therapy. However, existing methods, based on oversimplistic cell-to-cell proximity, are largely confounded by immune cell density and are ineffective in capturing tumor-immune spatial patterns. Here we developed a novel computational algorithm, termed Tumor-Immune Partitioning and Clustering (TIPC), to offer an effective solution for spatially informed tumor subtyping. Our method could measure the extent of immune cell partitioning between tumor epithelial and stromal areas as well as the degree of immune cell clustering. Using a U.S. nation-wide colorectal cancer database, we showed that TIPC could determine tumor subtypes with unique tumor-immune spatial patterns that were significantly associated with patient survival and key tumor molecular features. We also demonstrated that TIPC was robust to parameter settings and readily applicable to different immune cell types. The capability of TIPC in delineating clinically relevant patient subtypes that encapsulate tumor-immune spatial relationship, immune density, and tumor morphology is expected to shed light on underlying immune mechanisms. Hence, TIPC can be a useful bioinformatics tool for effective characterization of the spatial composition of the tumor-immune microenvironment to inform precision immunotherapy.