gebhart/patrepeval huggingface dataset:
Characterization of experimental mitoxantrone cardiotoxicity and its partial inhibition by ICRF-187 in cultured neonatal rat heart cells. (1993)

Mitoxantrone cardiotoxicity was investigated in isolated neonatal rat heart myocytes treated for 3 h in the presence or absence of the metal chelator ICRF-187. Electron microscopy studies of mitoxantrone-treated myocytes showed disorganized myofibrillar structures, swollen mitochondria, and extensive vacuolization. Cardiotoxicity, reflected as the ratio of intracellular ATP/protein and the loss of spontaneous beating, was only partially reduced by continuous ICRF-187 concentrations up to 50 micrograms/ml. ICRF-187 induced myocyte protection which was dependent on the dose and duration of exposure. ICRF-187 also reduced the cardiotoxicity of doxorubicin to a lesser extent and reduced the toxicity of a postulated cyclic mitoxantrone metabolite. However, the cardiotoxicity of ametantrone, a nonmetal-binding analogue of mitoxantrone, was unaltered with ICRF-187. The antitumor activity of mitoxantrone was unaltered by ICRF-187 in human tumor cells and in P-388-bearing mice. In addition, ICRF-187 allowed for 50% greater cumulative dosing in normal mice that, nonetheless, showed extensive histological heart damage 7 wk after dosing. These studies show that ICRF-187 provides partial protection from mitoxantrone cardiotoxicity in vitro without impairing the drug's antitumor activity in vitro or in vivo. This facilitates greater cumulative drug dosing in normal mice. The postulated mechanism of cardioprotection is metal chelation, because ICRF-187 did not alter the toxicity of a nonchelating mitoxantrone analogue.
Structural and chemical characterization of TiO2memristive devices by spatially-resolved NEXAFS (2009)

We used spatially-resolved NEXAFS (near-edge x-ray absorption fine structure) spectroscopy coupled with microscopy to characterize the electronic, structural and chemical properties of bipolar resistive switching devices. Metal/TiO2/metal devices were electroformed with both bias polarities and then physically opened to study the resulting material changes within the device. Soft x-ray absorption techniques allowed isolated study of the different materials present in the device with 100 nm spatial resolution. The resulting morphology and structural changes reveal a picture of localized polarity-independent heating occurring within these devices initiated by and subsequently accelerating polarity-dependent electrochemical reduction/oxidation processes.
FIGURE 2 from Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T Cells Administered Intravenously in Patients with Melanoma and Breast Carcinoma (2023)

&lt;p&gt;IHC analysis of CD8 in preinfusion and postinfusion tumor tissue. Three subjects had preinfusion and postinfusion tumor tissue available for analysis; postinfusion tumor tissue demonstrated an increase in cytoxic CD8&lt;sup&gt;+&lt;/sup&gt; cells in all 3 subjects.&lt;/p&gt;
A Micromechanics-based Study on Cracking Characteristics of Engineered Geopolymer Composite (2023)

This study aims at experimentally and analytically characterizing cracking characteristics of Engineered Geopolymer Composites (EGCs) and at identifying optimal combinations of micromechanical parameters for enhancing the composite tensile performance. Fly ash-based EGCs with different volume fractions of polyvinyl alcohol fibers are investigated. The number of cracks and residual crack widths are measured for EGC specimens uniaxially loaded to 1% and 2% tensile strain. The observed crack patterns are analyzed by a micromechanics-based model that relates matrix, fiber, and interface properties to the macroscopic composite behavior. The experimental results demonstrate the lognormal distributions of crack widths and more tightly controlled cracking compared to Engineered Cementitious Composites. The simulated fiber bridging stress-crack opening relationship (σ-δ relationship) suggests that relatively high chemical bond and low frictional bond lead to the tight crack width. The simulation results also suggest that the first-cracking strength and the subsequent micro-cracking stress during the hardening stage should be below the analytical σ-δ curve peak. Higher chemical bond is beneficial for meeting these conditions, but if it is too high, fiber rupture dominates over pull-out, which lowers the complementary energy. Lower frictional bond or slip-hardening coefficient can suppress the fiber rupture tendency.
Antibody response to embryonal carcinoma cells in syngeneic mice (1979)

The immunoglobulin (Ig) classes and subclasses of the specific antibodies contained in antisera raised in male 129/Sv mice against cells of a syngeneic clonal line of embryonal carcinoma (F9) have been determined. Cytotoxic activity was found associated almost exclusively with anti-F9 IgM (micro kappa) antibodies. A large part of anti-F9 activity was found associated with IgG1 (gamma 1 kappa and presumably also gamma 1 lambda) antibodies, and was detectable only by direct immunofluorescence. Traces of specific IgG2a and IgG2b antibodies were also found. No IgG3 and IgA antibodies reacting with embryonal carcinoma cells were detectable under these conditions. The serum of F9 tumor-bearing animals had a very similar Ig composition. Furthermore, IgM and IgG1, but not IgG2 antibodies, were detected at the surface of in vivo growing F9 tumor cells.
Renal allograft failure due to recurrent dense intramembranous deposit disease. (1984)

Dense intramembranous deposit disease (DIDD) almost universally recurs in renal allografts. However, the 29 previously reported cases suggest that recurrent DIDD rarely results in graft failure. We studied the clinical course and renal histology of the 6 patients with DIDD who have received renal allografts here since 1967. All patients had characteristic findings of DIDD in their native kidneys by light, immunofluorescence and electron microscopy. Seven grafts in 4 patients failed and histological evaluation showed that 5 of these allografts in 4 patients were lost due to recurrent disease. They all demonstrated marked mesangial proliferation with crescents but minimal acute interstitial or vascular changes of rejection. Patients with graft failure due to recurrent disease were male and developed recurrent nephrotic syndrome. The 2 patients with rapidly progressive glomerulonephritis (RPGN) in their native kidneys lost the transplanted kidney due to recurrent disease within 1 year. This study suggests that recurrence of DIDD in renal allografts is a more serious problem than previously appreciated, especially in patients with RPGN.
Quality Enhancement of Compressed Video Signals (2008)

This paper presents a new method for enhancement of the visual quality of compressed video sequences. The algorithm reduces coding artifacts and enhances sharpness of image details using combined filtering that ensures low implementation cost and high quality. Parameters of the combined bilateral filter are controlled by a block grid visibility metric, local entropy value, and dynamic range of pixel values. The results of our experiments show the high efficiency of the proposed approach.
Insulin Resistance and Inflammation as Precursors of Frailty (2007)

Two physiologic components of MetS- IR-HOMA and inflammation-are associated with incident frailty. Based on these results, IR-HOMA can be considered part of a larger process that leads to generalized decline.
SRv6 Implementation and Deployment Status (1999)

This draft provides an overview of IPv6 Segment Routing (SRv6)
deployment status. It lists various SRv6 features that have been
deployed in the production networks. It also provides an overview of
SRv6 implementation and interoperability testing status.
Controlling the Sensing Properties of Silicon Nanowires via the Bonds Nearest to the Silicon Nanowire Surface (2015)

Controlling the sensing properties of a silicon nanowire field effect transistor is dependent on the surface chemistry of the silicon nanowire. A standard silicon nanowire has a passive oxide layer (native oxide), which has trap states that cause sensing inaccuracies and desensitize the surface to nonpolar molecules. In this paper, we successfully modified the silicon nanowire surface with different nonoxide C3 alkyl groups, specifically, propyl (Si-CH2-CH2-CH3), propenyl (Si-CH═CH-CH3), and propynyl (Si-C≡C-CH3) modifications. The effect of the near surface bond on the sensor sensitivity and stability was explored by comparing three C3 surface modifications. A reduction of trap-states led to greater sensor stability and accuracy. The propenyl-modified sensor was consistently the most stable and sensitive sensor, among the applied sensors. The propenyl- and propynyl-modified sensors consistently performed with the best accuracy in identifying specific analytes with similar polarity or similar molecular weights. A combination of features from different sensing surfaces led to the best rubric for specific analytes identification. These results indicate that nonoxide sensor surfaces are useful in identifying specific analytes and that a combination of sensors with different surfaces in a cross-reactive array can lead to specific analytes detection.
S? ADC with Fractional Sample Rate Conversion for Software Defined Radio Receiver (2011)

An analog-to-digital converter (ADC) in a software defined radio (SDR) receiver must be able to support the specifications of various wireless standards. It should also work with the low power supply voltage of CMOS circuits. A ΣΔ ADC is one of the solutions for the SDR receiver. However, the power
Fig S5 from A Bispecific METxMET Antibody–Drug Conjugate with Cleavable Linker Is Processed in Recycling and Late Endosomes (2023)

&lt;p&gt;Rabs KO Endocytosis&lt;/p&gt;
Measurement of transverse energy–energy correlations in multi-jet events in pp collisions at s=7 TeV using the ATLAS detector and determination of the strong coupling constant αs(mZ) (2015)

Measurement of transverse energy-energy correlations in multi-jet events in pp collisions at s = 7 TeV using the ATLAS detector and determination of the strong coupling constant s (m Z )
Simultaneous 7-Core Pumped Amplification in Multicore EDF through Fibre Based Fan In/Out (2012)

We demonstrate multicore EDFA with simultaneous 7 core pump by utilizing small diameter fibre bundle fan in/out. We confirm the characteristics with the gain &gt; 15 dB, the noise figure &lt; 7 dB, and the crosstalk &lt; −40 dB in C band. Seven 10 Gbit/s NRZ data are simultaneously amplified in each core with the power penalty within 0.5 dB.
Semicrystalline Polymers via Ring-Opening Polymerization:  Preparation and Polymerization of Alkylene Phthalate Cyclic Oligomers (1998)

Preparation of cyclic oligomeric alkylene phthalates via pseudo-high dilution condensation of alkylene diols with iso- and terephthaloyl chlorides and conversion to high molecular weight polyesters via ring-opening polymerization is described. Sterically unhindered amines such as quinuclidine or 1,4-diazabicyclo[2.2.2]octane (DABCO) catalyze the condensation significantly faster than other tertiary amines and are useful for carrying out this conversion in high yield, in the first direct reaction of diol and diacid chloride to form cyclic polyesters. The mixtures of oligomeric cyclics melt at 150-200 degrees C, providing liquids of low viscosity. Ring-opening polymerization using tin or titanate catalysts affords high molecular weight polymers within minutes. Complete polymerization of PBT oligomeric cyclics can be achieved at 180-200 degreesC, significantly below the polymer's melting point of 225 degreesC, and with molecular weights as high as 445 x 10(3). Polymers formed via such a process are more crystalline than conventionally prepared polyesters.
Minor sequence modifications in temporin B cause drastic changes in antibacterial potency and selectivity by fundamentally altering membrane activity (2019)

Antimicrobial peptides (AMPs) are a potential source of new molecules to counter the increase in antimicrobial resistant infections but a better understanding of their properties is required to understand their native function and for effective translation as therapeutics. Details of the mechanism of their interaction with the bacterial plasma membrane are desired since damage or penetration of this structure is considered essential for AMPs activity. Relatively modest modifications to AMPs primary sequence can induce substantial changes in potency and/or spectrum of activity but, hitherto, have not been predicted to substantially alter the mechanism of interaction with the bacterial plasma membrane. Here we use a combination of molecular dynamics simulations, circular dichroism, solid-state NMR and patch clamp to investigate the extent to which temporin B and its analogues can be distinguished both in vitro and in silico on the basis of their interactions with model membranes. Enhancing the hydrophobicity of the N-terminus and cationicity of the C-terminus in temporin B improves its membrane activity and potency against both Gram-negative and Gram-positive bacteria. In contrast, enhancing the cationicity of the N-terminus abrogates its ability to trigger channel conductance and renders it ineffective against Gram-positive bacteria while nevertheless enhancing its potency against Escherichia coli. Our findings suggest even closely related AMPs may target the same bacterium with fundamentally differing mechanisms of action.
Characterization of the In Vivo Forces on the Sternum in Pigs (2007)

Approximately 15,000 Americans suffer complications associated with inadequate sternal fixation after open-heart surgery each year [1]. Although alternative fixation methods exist, limitations of current device evaluation systems have led to uncertainty about the relative increase in stability that these novel devices provide, thereby diminishing their widespread clinical use. Sternal closure techniques are typically evaluated in situ where estimated sternal forces (180–400N) are applied to an intact chest [2] or in vitro on isolated sternal models [3]. The mechanical stability afforded by each technique is quantified as the resultant separation along the bisected sternal midline. This displacement is assumed to reflect micro-motion that would occur at the wound site under physiological loading, a critical factor during bony healing [4]. However, the loading in these studies is hardly physiological; it is generally simplified to a single direction and applied quasistatically to only a few discrete locations along the sternum without regard for the in vivo distribution of forces. It is also unclear whether the transfer of loads from sternum to fixation device during in situ tests [5](cadavers) accurately reflects loading in vivo due to the potential effects of rigor mortis and/or embalming. To improve the accuracy of current in situ and in vitro sternal fixation test methods it is essential to advance our knowledge of in vivo dynamic multi-directional sternal loading.
Synthesis of a Barium Sulfate Nanoparticle Contrast Agent for Micro‐Computed Tomography of Bone Microstructure (2006)

This chapter contains sections titled: Introduction Experimental Methods Results Discussion Acknowledgements
Atrial myxomas in young children: an alternative surgical approach. (1993)

A case report and a brief review of the literature on atrial myxomas in young children (5 years and younger) are presented. Right atrial myxomas are predominant in this age group in contrast to older children and adults. The echocardiogram alone can provide clear anatomic information for the operation. For large left atrial myxomas, wide exposure through a transverse biatrial incision is recommended to avoid tumor manipulation and facilitate en bloc resection.
Effects of Cashew Kernels Cake on the Nutritional and Sensory Quality of Hen Eggs (2023)

Cashew kernels provide fats, proteins, minerals and amino acids like soybeans. They are characterized by their richness in linoleic and oleic acids which respectively contribute up to 20% and 60% of the fat. The aim of the present study is to assess the impact of the diets of laying hens, based on of cashew nut kernels cakes, on the nutritional and sensory quality of eggs. To carry out the experiment, 20 weeks old, 96 hens of the LOHMAN-Brown strain and with an average weight of 1600 g, were used over a period of 10 weeks. Laying hens were fed four diets Rt, R10, R15 and R20 at incorporation rates of 0%, 10%, 15% and 20% cashew kernel cake, respectively. The results indicate that the R10, R15 and R20 diets, after two weeks of testing, were associated with a reduction of up to 34.50% in egg yolk cholesterol content, compared to the Rt control diet. In sensory analysis tests, panelists accepted eggs from different diets without distinction. In short, far from degrading the quality of eggs, the dietary the lipids in cashew kernel cake can contribute to the development of poultry production by providing the consumer the fatty acids recommended by the medical profession.
Géodésiques sémantiques pour la description et la labélisation automatique de parties (2014)

National audience
P‐79: Model of Freedericksz Transition and Hysteresis Effect in Polymer Stabilized Nematic Liquid Crystal Configurations for Display Applications (2002)

Abstract The critical field of the Freedericksz transition and optical hysteresis is investigated for Polymer Stabilized Nematic Liquid Crystals as a function of polymer concentration. The results are described by a simple phenomenological model, which accounts for the change in polymer network morphology as the concentration of polymer is increased.
Enolase-1 as a plasminogen receptor (2009)

In this issue of Blood, Wygrecka and colleagues assign a major role to cell-surface enolase-1 as a plasminogen receptor, mediating LPS-induced invasion of monocytes into lungs in mice and humans.
Integration of photodetectors with lasers for optical interconnects using 200 mm waferscale III-V/SOI technology (2011)

We demonstrate efficient photodetectors on top of a laser epitaxial structure completely fabricated using 200 mm wafer scale III–V/SOI technology enabling very dense integration of lasers and detectors for optical interconnect circuits.
Myeloperoxidase Inhibition in Heart Failure With Preserved or Mildly Reduced Ejection Fraction: SATELLITE Trial Results (2023)

Few treatments are available for patients with the forms of heart failure known as heart failure with preserved or mildly reduced ejection fraction. Current treatments do not target inflammation, which may play an important role in this condition. We tested a new drug called AZD4831 (mitiperstat), which decreases inflammation by inhibiting the enzyme myeloperoxidase. Among the 41 patients in our clinical trial, AZD4831 had a good safety profile and inhibited myeloperoxidase by the expected amount. Results mean we can conduct further trials to see whether AZD4831 decreases the symptoms of heart failure and improves patients' ability to participate in physical exercise.
No One's World: The West, the Rising Rest, and the Coming Global Turn. By Charles A. Kupchan. New York: Oxford University Press, 2012. 272p. $27.95. (2013)

In this provocative new book, Charles Kupchan issues a clarion call to the advanced industrial nations of the West. The global order they have built over two centuries—a system based on liberal democracy at home and free trade abroad—is meeting its demise, he warns. New nations have arisen that neither share the West's historical traditions nor aspire to its contemporary values. The advanced industrial West, Kupchan argues, cannot logically expect nations like China, India, Brazil, and Russia to voluntarily comply with an existing order that is alien to their experiences and unaccommodating to their interests. Nor can the West realistically strong-arm such nations. The fulcrum of relative power has shifted too far to make coercion possible. But the West, he asserts, must not stand idly by. Historically, power transitions—save for a few rare exceptions—have tended to engender violent conflict. This time will be no different, says the author, unless the West moves aggressively to foster a new and far more inclusive global order.
Packetised Data Communications (2016)

This chapter gives an overview of packet switching technologies and protocols. Packet-switched communication facilitates independent transmission of the data packets towards the destination. Packet-switched architectures divided the processes necessary for establishing and transmitting of data into ‘layers’. The Open Systems Interconnection (OSI) model defined seven functional layers. The OSI architecture defines the interfaces between layers and therefore different software and hardware vendors may design and develop products for data communications networking. The OSI seven-layer architecture is overtaken by the internet protocol (IP) suite in carrying most packet-switched data traffic. The chapter discusses packet-switched communications using the internet protocol (IP). Internet packets are individually and independently forwarded at each network node. Two modes exist for forwarding packets at a network node: switching; and routing.
Direct Catalytic Enantioselective Aza‐Diels–Alder Reactions (2005)

Prolin und seine Derivate katalysieren die asymmetrische Dreikomponenten-Eintopf-Aza-Diels-Alder-Reaktion zwischen α,β-ungesättigten cyclischen Ketonen, wässrigem Formaldehyd und Arylaminen mit ausgezeichneten Chemo- und Enantioselektivitäten (siehe Schema). Die Reaktion führt überdies hoch enantioselektiv zu bicyclischen nichtproteinogenen Aminosäurederivaten.
Process Development of the Synthesis and Purification of a Reactive Immuno-PET Conjugate Intermediate (2016)

We describe a practical multigram scale synthesis of the reactive immuno-PET linker-chelator GNE-605 from the commercially available starting material desferrioxamine B mesylate. A modified three-step synthetic procedure was developed that significantly reduces the amount of solvents and reagents required as compared to previous literature. Additionally, due to the unique handling challenges posed by this reactive intermediate, a liquid chromatography purification and lyophilization procedure was developed to allow for the first isolation of GNE-605 as a solid material.
Effect of a Transverse Tensile Stress on the Electric‐Field‐Induced Domain Reorientation in Soft PZT: In Situ XRD Study (2002)

The effect of a transverse tensile stress on the electric‐field‐induced 90°‐domain reorientation in tetragonal lead zirconate titanate (PZT) near the morphotropic phase boundary was investigated in situ using X‐ray diffraction (XRD). The XRD intensity ratio, I (002) / I (200) , which represents the ratio of the volume of the c ‐domains to that of the a ‐domains on the PZT surface, was examined as a function of the electric field at various stress levels. It was found that a transverse tensile stress changes the electric‐field dependence of I (002) / I (200) , especially at higher electric fields. Without a transverse tensile stress, I (002) / I (200) began to saturate at E ≈ 800 kV/m. With a transverse tensile stress of 75 MPa, I (002) / I (200) increased with an upward curvature with the electric field, indicating that the transverse tensile stress enhanced the field‐induced 90°‐domain reorientation, and increased the effective piezoelectric coefficients at larger electric fields. At E = 900 kV/m, the estimated d 31,domain changed from −200 × 10 −12 V/m at zero stress, to −350 × 10 −12 V/m at 75 MPa.