gebhart/patrepeval huggingface dataset:
Micro and nanopore structures for biological applications (2002)

The power of micromachining of structures in silicon is now begining to be fully exploited in biotechnology. The author gives three examples of what kinds of structures can be made and their applications. (1) The development of our understanding of the parameters necessary for successful separation and fabrication of sufficiently small structures for sequencing. (2) Cell fractionation from whole blood. (3) Protein folding. This is a new project. The idea is to use a combination of micron-scale structures, hydrodynamic focusing and diffusional mixing to achieve microsecond mixing times of renaturing solvents with a denatured protein solution.
A Scalable Neural Shortlisting-Reranking Approach for Large-Scale Domain Classification in Natural Language Understanding (2018)

Young-Bum Kim, Dongchan Kim, Joo-Kyung Kim, Ruhi Sarikaya. Proceedings of the 2018 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies, Volume 3 (Industry Papers). 2018.
Supplementary Methods, Table 1, Figure Legends 1-4 from SMYD3 Promotes Cancer Invasion by Epigenetic Upregulation of the Metalloproteinase <i>MMP-9</i> (2023)

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One-pair measurement system for efficient imaging performance evaluation of prototype DOI-PET detectors (2012)

DOl-PET detectors can provide good imaging performance even in the peripheral region of the PET FOV. In the development of DOl-PET detectors, one of the important steps toward their practical use is an evaluation of imaging performance such as the spatial resolution measured by using a point source and a one-pair system which simulates actual PET geometries. Because the DOl-PET detectors have an extended FOV compared with conventional detectors, evaluation including the region from the center to the periphery close to the detector ring is required to show their advanced performance for uniform spatial resolution. In this study, we proposed a one-pair system that can simulate an arbitrary ring diameter and acquire projection data efficiently by cutting unnecessary combinations according to the position of the point source. When we compared results by the full measurement scheme, the proposed system and our measuring scheme could significantly reduce the measurement time especially for a large ring size such as used in brain PET scanners. We used the system to evaluate the X'tal cube PET detector with a 2 mm crystal array arranged in a simulated PET geometry with the ring radius of 73 mm and 18 detector blocks. The results showed that uniform spatial resolution was achieved even in the peripheral region and measurements were obtained semi-automatically in a short time.
Heteroepitaxial growth of (111) 3C–SiC on well-lattice-matched (110) Si substrates by chemical vapor deposition (2004)

Heteroepitaxial growth of 3C–SiC on (110) Si substrates by chemical vapor deposition was carried out, and the grown epitaxial layers were investigated by high resolution transmission electron microscopic (HRTEM) analysis. The interface structure between 3C–SiC and Si substrates depended on the flow rate of C3H8 during the carbonization process. In the case of the growth under C3H8=0.4 sccm, the interface was flat and 3C–SiC layer was grown epitaxially on (110) Si substrate in a well-lattice-matched relationship of (110) Si//(111) 3C–SiC and [1̄10] Si//[1̄10] 3C–SiC. In contrast, the interface was rough under C3H8=1.2 sccm and polycrystalline 3C–SiC grew without epitaxial relationship to the substrate. HRTEM observations revealed that an atomically flat (110) Si substrate surface is significant in order to grow high quality 3C–SiC with suppressing the generation of stacking faults.
Preliminary assessment of safety and effectiveness in humans of ProBiora3 ™, a probiotic mouthwash (2009)

The results of this pilot human study suggest that the probiotic mouthwash product may be safe for daily use as an aid in maintaining both dental and periodontal health.
The Use of Suramin, an Antifibrotic Agent, to Improve Muscle Recovery after Strain Injury (2004)

These results may facilitate the development of strategies to enhance muscle healing after injury.
Amine‐Reactive Monolayers on Scribed Silicon with Controlled Levels of Functionality: Reaction of a Bare Silicon Surface with Mono‐ and Diepoxides (2003)

An „nackten“ Silicium-Oberflächen werden Epoxide unter Ringöffnung gebunden (siehe Schema). Mit Diepoxiden entstehen Monoschichten, die mit Aminen reagieren können. Das Ausmaß der Epoxyfunktionalisierung kann durch Verwendung von Gemischen aus 1,2-Epoxyoctan und 1,2,7,8-Diepoxyoctan eingestellt werden.
Methods of making organic compounds by metathesis (2023)

Described are methods of making organic compounds by metathesis chemistry. The methods of the invention are particularly useful for making industrially-important organic compounds beginning with starting compositions derived from renewable feedstocks, such as natural oils. The methods make use of a cross-metathesis step with an olefin compound to produce functionalized alkene intermediates having a pre-determined double bond position. Once isolated, the functionalized alkene intermediate can be self-metathesized or cross-metathesized (e.g., with a second functionalized alkene) to produce the desired organic compound or a precursor thereto. The method may be used to make bifunctional organic compounds, such as diacids, diesters, dicarboxylate salts, acid/esters, acid/amines, acid/alcohols, acid/aldehydes, acid/ketones, acid/halides, acid/nitriles, ester/amines, ester/alcohols, ester/aldehydes, ester/ketones, ester/halides, ester/nitriles, and the like.
Design of an Electronic Upload and Reporting System aimed at Corelab Tasks and Responsibilities in Multi:center Clinical Trials (2016)

In multicenter clinical trials images are interpreted and analyzed by an imaging core laboratory (ICL) to generate consistent results with the least possible variance.
65nm CMOS Burst Generator for Ultra-Wideband Low Data Rate Systems (2007)

This paper presents a novel burst generator architecture dedicated to Ultra Wideband wireless communication systems based on Impulse Radio techniques. Bursts are generated by using an oscillator output signal controlled both in magnitude and phase with a high-speed digital circuit in order to limit output signal bandwidth in accordance with IEEE 802.15.4a standard requirements. The design has been integrated on a single-chip in the 65nm CMOS STMicroelectronics technology under a 1.2 V supply voltage and functionnal measurements are presented.
The Detergent Effect of Mesalazine Interferes with Phosphatidylcholine Binding to Mucin 2 (2018)

Mesalazine solubilizes PC and, thus, prevents the protective action of therapeutically applied delayed-release PC within mucus.
Physical model-set identification for robust control of flexible structures (1993)

An approach to dynamic system identification is presented taking into account the goal of enhancing robust control performance of flexible structures. Identification techniques are derived which take advantage of the physics of structural dynamics and can provide realistic bounds for all potential parameter uncertainties. The developed approach includes input optimization which distributes excitation energy in such a way that the influence of residual uncertainties on robust control performance is reduced.
A new pad-oriented multiple-mode ESD protection structure and layout optimization (2001)

This work reports a new multiple-mode pad-oriented electrostatic discharge (ESD) protection structure, which protects input-output pads against ESD pulses of all modes. A unique pad-based quasi-symmetric layout design is devised to improve ESD robustness. The new ESD structure features tunable triggering voltage, low holding voltage, low on-impedance, low leakage (/spl sim/pA), fast response time (/spl sim/0.18 ns), and low parasitic effect. It can be placed under a bond pad and consumes little silicon. It passed 14 kV human body model and 15 kV air-gap International Electrotechnical Commission ESD zapping. It was demonstrated in commercial BiCMOS processes and is suitable for multiple-supply mixed-signal, parasitic-sensitive RF and high-pin-count ICs.
In Vivo SPECT Imaging of Amyloid-β Deposition with Radioiodinated Imidazo[1,2-a]pyridine Derivative DRM106 in Mouse Model of Alzheimer’s Disease (2014)

Non-invasive determination of amyloid- peptide (Ab) deposition has important significance for early diagnosis and medical intervention for Alzheimer’s disease (AD). In the present study, we investigated the availability of radiolabeled DRM106 (123/125I-DRM106), a compound with sufficient affinity for the synthesis of human Ab fibrils and satisfactory metabolic stability, as a single photon emission computed tomography (SPECT) ligand in living brains. Method: The sensitivity of 125I-DRM106 for detecting Ab deposition was compared with 125I-IMPY, a well-known amyloid SPECT ligand, by ex vivo autoradiographic analyses in 18-month-old amyloid precursor protein transgenic (Tg) mice. To verify the sensitivity and quantitation of radiolabeled DRM106 for in vivo imaging, we compared the detectability of A plaques with 123I-DRM106 and a well-known amyloid positron emission tomography (PET) agent, 11C-labeled Pittsburgh compound B (11C-PiB), in 29-month-old Tg mice and age-matched non-Tg littermates. Additionally, we compared the binding characteristics of 125I-DRM106 with those of 11C-PiB and 11C-PBB3, which selectively bind to A plaques and preferentially to tau aggregates, respectively, in postmortem AD brain sections. Results: Ex vivo autoradiographic analysis showed that measurement with 125I-DRM106 has higher sensitivity for detecting Ab accumulation than with 125I-IMPY in Tg mice. SPECT imaging with 123I-DRM106 also successfully detected Ab deposition in living aged Tg mice, and showed strong correlation (R = 0.95, p &lt; 0.01) in quantitative analysis for Ab plaque detection by PET imaging with 11C-PiB, implying that sensitivity and quantitation of SPECT imaging with 123I-DRM106 are almost as good as 11C-PiB-PET for the detectability of Ab deposition. Further, the addition of non-radiolabeled DRM106 fully blocked the binding of 125I-DRM106 and 11C-PiB, but not 11C-PBB3, to AD brain sections, and 125I-DRM106 showed a lower binding ratio of the diffuse plaque-rich lateral temporal cortex to the dense cored/neuritic plaque-rich hippocampal CA1 area, compared to 11C-PiB. Conclusion: All of these data demonstrated the high potential of 123I-DRM106 for amyloid imaging in preclinical and clinical application, and it might more preferentially detect dense-cored/neuritic amyloid deposition, which is expected to be closely associated with neuropathological changes of AD.
Synthesis and Characterization of Single-Crystal Strontium Hexaboride Nanowires (2008)

Catalyst-assisted growth of single-crystal strontium hexaboride (SrB6) nanowires was achieved by pyrolysis of diborane (B2H6) over SrO powders at 760-800 degrees C and 400 mTorr in a quartz tube furnace. Raman spectra demonstrate that the nanowires are SrB6, and transmission electron microscopy along with selected area diffraction indicate that the nanowires consist of single crystals with a preferred [001] growth direction. Electron energy loss data combined with the TEM images indicate that the nanowires consist of crystalline SrB 6 cores with a thin (1 to 2 nm) amorphous oxide shell. The nanowires have diameters of 10-50 nm and lengths of 1-10 microm.
Effective Use of Percutaneous Stellate Ganglion Blockade in Patients With Electrical Storm (2019)

SGB effectively attenuated electrical storm in more than half of patients without procedure-related complications. Percutaneous SGB may be considered for stabilizing ventricular rhythm in patients for whom other therapies have failed.
Evidence of Antineutrinos from Distant Reactors Using Pure Water at SNO+ (2023)

The SNO+ Collaboration reports the first evidence of reactor antineutrinos in a Cherenkov detector. The nearest nuclear reactors are located 240 km away in Ontario, Canada. This analysis uses events with energies lower than in any previous analysis with a large water Cherenkov detector. Two analytical methods are used to distinguish reactor antineutrinos from background events in 190 days of data and yield consistent evidence for antineutrinos with a combined significance of 3.5σ.
Blocking of the placental immune-modulatory ferritin activates Th1 type cytokines and affects placenta development, fetal growth and the pregnancy outcome (2004)

This study provides the first in vivo evidence that PLIF plays a major role in placentation and embryonic growth.
Identifying Sn Site Heterogeneities Prevalent Among Sn‐Beta Zeolites (2016)

In recent years, various protocols on preparing Lewis acidic Sn‐ β zeolite hydrothermally and postsynthetically have been reported. However, very little is known about the effects of different synthesis protocols on the Sn( IV ) speciation in the final material. Even the effects of individual synthesis parameters within a certain preparation method have not been studied systematically. Here, we demonstrate that hydrothermally synthesized Sn‐ β zeolites prepared via very similar recipes show significantly different 119 Sn‐ NMR spectra, suggesting different Sn site speciation. Among postsynthetically prepared Sn‐ β zeolites, less variation in the resulting 119 Sn‐ NMR spectra have been observed, indicating a more reproducible synthesis procedure compared to hydrothermal synthesis in fluoride media. This work highlights the importance of 119 Sn‐ NMR measurements to elucidate the precise local geometry of the Sn heteroatoms in Sn‐ β , and the need to quantify the number of reactive Sn sites on each sample that participate in a given catalytic reaction, in order to accurately compare materials prepared by different routes.
DNA-Based Immunization Breaks Tolerance in a Hepatitis C Virus Transgenic Mouse Model (2006)

Chronic hepatitis C infection (HCV) is associated with high morbidity and mortality due to limited treatment options. HCV transgenic mice can be used as surrogate model of chronic HCV infection and may therefore be a small animal model for the evaluation of therapeutic vaccination strategies. We immunized transgenic mice expressing HCV structural proteins with an HCV core and a mouse IL-2 expression plasmid to study the cellular and humoral immune responses. DNA-based immunization induced a significant CD4+ T cell proliferative response and a CD8+ cytotoxic T cell response. Only low amounts of anti-HCV core antibodies were detected after genetic immunization. No liver damage was observed in the liver of immunized mice despite low level HCV core transgene expression and the presence of peripheral cellular immunity. These results demonstrate that DNA-based immunization may result in activation of previously tolerant T cells and is therefore a promising approach for treatment of chronic HCV infection.
Perovskite solar cell for photocatalytic water splitting with a TiO2/Co-doped hematite electron transport bilayer (2018)

Hydrogen production using a photoelectrochemical (PEC) route promises to be a clean and efficient way of storing solar energy for use in hydrogen-powered fuel cells. Iron oxide (α-Fe<sub>2</sub>O<sub>3</sub>) is best suited to be used as a photoelectrode in PEC cells for solar hydrogen production due to its favorable band gap of ∼2.2 eV. Herein, chemical solution deposition was used for the preparation of a series of Co-doped Fe<sub>2</sub>O<sub>3</sub> thin films on a titania buffer layer at different doping concentrations (3.0, 7.0 and 10.0 at%). The maximum anodic photocurrent reached up to 3.04 mA cm<sup>-2</sup> by optimizing the balance between the doping concentrations, enhanced donor density, light absorbance, and surface roughness. The optical properties show that the light absorbance tendency switches to the higher wavelength with the further increment of Co beyond 3.0%. Finally, synthesized photosensitive perovskite CH<sub>3</sub>NH<sub>3</sub>PbI<sub>3</sub> materials were added as a surface treatment agent on the photoelectrode to enhance the photocurrent absolute value. This inorganic nanostructured perovskite CH<sub>3</sub>NH<sub>3</sub>PbI<sub>3</sub> (MAPbI<sub>3</sub>) coated on the Co-doped hematite photoanode achieved an overall solar-to-hydrogen conversion efficiency of 2.46%. Due to its low temperature processing, stability, and enhance efficiency, this perovskite coated TiO<sub>2</sub>/Co-doped hematite multilayer thin film solar cell has high potential to be applied in industry for hydrogen production.
TEMOS: Generating diverse human motions from textual descriptions (2022)

We address the problem of generating diverse 3D human motions from textual descriptions. This challenging task requires joint modeling of both modalities: understanding and extracting useful human-centric information from the text, and then generating plausible and realistic sequences of human poses. In contrast to most previous work which focuses on generating a single, deterministic, motion from a textual description, we design a variational approach that can produce multiple diverse human motions. We propose TEMOS, a text-conditioned generative model leveraging variational autoencoder (VAE) training with human motion data, in combination with a text encoder that produces distribution parameters compatible with the VAE latent space. We show the TEMOS framework can produce both skeleton-based animations as in prior work, as well more expressive SMPL body motions. We evaluate our approach on the KIT Motion-Language benchmark and, despite being relatively straightforward, demonstrate significant improvements over the state of the art. Code and models are available on our webpage.
A new polymorphic probe on chromosome 3p: lambda LIB13-67 (D3S591). (1991)

A new polymorphic probe on chromosome 3p: λLIB37–96′ (D3S1192) F. Latif, F. Latif Search for other works by this author on: Oxford Academic PubMed Google Scholar G.M. Glenn, G.M. Glenn Search for other works by this author on: Oxford Academic PubMed Google Scholar L. Geil, L. Geil 1Biological Carcinogenesis and Development Program, Program Resources Inc., DynCorp, Frederick Cancer Research and Development CenterFrederick, MD 21701, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Delisio, J. Delisio 1Biological Carcinogenesis and Development Program, Program Resources Inc., DynCorp, Frederick Cancer Research and Development CenterFrederick, MD 21701, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar B. Zbar, B. Zbar Search for other works by this author on: Oxford Academic PubMed Google Scholar M.I. Lerman M.I. Lerman * * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 19, Issue 16, 25 August 1991, Page 4567, https://doi.org/10.1093/nar/19.16.4567-a Published: 25 August 1991
Reduction of Coactivator Expression by Antisense Oligodeoxynucleotides Inhibits ERα Transcriptional Activity and MCF-7 Proliferation (2002)

Steroid receptor RNA activator (SRA) is a novel coactivator for steroid receptors that acts as an RNA molecule, whereas steroid receptor coactivator (SRC) family members, such as steroid receptor coactivator-1 (SRC-1) and transcriptional intermediary factor 2 (TIF2) exert their biological effects as proteins. Individual overexpression of each of these coactivators, which can form multimeric complexes in vivo, results in stimulated ERalpha transcriptional activity in transient transfection assays. However there is no information on the consequences of reducing SRC-1, TIF2, or SRA expression, singly or in combination, on ERalpha transcriptional activity. We therefore developed antisense oligodeoxynucleotides (asODNs) to SRA, SRC-1, and TIF2 mRNAs, which rapidly and specifically reduced the expression of each of these coactivators. ERalpha-dependent gene expression was reduced in a dose-dependent fashion by up to 80% in cells transfected with these oligonucleotides. Furthermore, treatment of cells with combinations of SRA, SRC-1, and TIF2 asODNs reduced ERalpha transcriptional activity to an extent greater than individual asODN treatment alone, suggesting that these coactivators cooperate, in at least an additive fashion, to activate ERalpha-dependent target gene expression. Finally, treatment of MCF-7 cells with asODN against SRC-1 and TIF2 revealed a requirement of these coactivators, but not SRA, for hormone-dependent DNA synthesis and induction of estrogen-dependent pS2 gene expression, indicating that SRA and SRC family coactivators can fulfill specific functional roles. Taken together, we have developed a rapid method to reduce endogenous coactivator expression that enables an assessment of the in vivo role of specific coactivators on ERalpha biological action and avoids potential artifacts arising from overexpression of coactivators in transient transfection assays.
Real‐time monitoring of quality attributes by in‐line Fourier transform infrared spectroscopic sensors at ultrafiltration and diafiltration of bioprocess (2020)

Technologies capable of monitoring product quality attributes and process parameters in real time are becoming popular due to the endorsement of regulatory agencies and also to support the agile development of biotherapeutic pipelines. The utility of vibrational spectroscopic techniques such as Fourier transform mid-infrared (Mid-IR) and multivariate data analysis (MVDA) models allows the prediction of multiple critical attributes simultaneously in real time. This study reports the use of Mid-IR and MVDA model sensors for monitoring of multiple attributes (excipients and protein concentrations) in real time (measurement frequency of every 40 s) at ultrafiltration and diafiltration (UF/DF) unit operation of biologics manufacturing. The platform features integration of fiber optic Mid-IR probe sensors to UF/DF set up at the bulk solution and through a flow cell at the retentate line followed by automated Mid-IR data piping into a process monitoring software platform with pre-loaded partial least square regression (PLS) chemometric models. Data visualization infrastructure is also built-in to the platform so that upon automated PLS prediction of excipients and protein concentrations, the results were projected in a graphical or numerical format in real time. The Mid-IR predicted concentrations of excipients and protein show excellent correlation with the offline measurements by traditional analytical methods. Absolute percent difference values between Mid-IR predicted results and offline reference assay results were ≤5% across all the excipients and the protein of interest; which shows a great promise as a reliable process analytical technology tool.
Real-time corneal segmentation and 3D needle tracking in intrasurgical OCT (2018)

Ophthalmic procedures demand precise surgical instrument control in depth, yet standard operating microscopes supply limited depth perception. Current commercial microscope-integrated optical coherence tomography partially meets this need with manually-positioned cross-sectional images that offer qualitative estimates of depth. In this work, we present methods for automatic quantitative depth measurement using real-time, two-surface corneal segmentation and needle tracking in OCT volumes. We then demonstrate these methods for guidance of <i>ex vivo</i> deep anterior lamellar keratoplasty (DALK) needle insertions. Surgeons using the output of these methods improved their ability to reach a target depth, and decreased their incidence of corneal perforations, both with statistical significance. We believe these methods could increase the success rate of DALK and thereby improve patient outcomes.