gebhart/patrepeval huggingface dataset:
RESULTS FROM THE UCLA/FNPL UNDERDENSE PLASMA LENS EXPERIMENT (2007)

A gaussian underdense plasma lens with peak density 5 × 10 12 cm −3 and a full width half maximum (FWHM) length of 2.2 cm has been used to focus a relativistic electron beam. This plasma lens is equivalent in strength to a quadrupole magnet with a 150 T/m field gradient. The lens focused a 15 MeV, 16 nC electron beam with initial dimensions σ x,y ≈ 650 μ m and σ z ≈ 6.5 mm onto an optical transition radiation (OTR) screen ~2 cm downstream of the lens. The average transverse area of the plasma focused electron beam was typically demagnified by a factor of 23. The evolution of the beam envelope in the area near the beam waist was measured for both round beams and asymmetric beams with x:y aspect ratios as large as 1:5. The light from the OTR screen in the round beam case was also imaged into a streak camera in order to directly measure the correlation between z and σ r within the beam.
Crosslinked Polypeptide Films via RAFT‐Mediated Continuous Assembly of Polymers (2021)

Polypeptide coatings are a cornerstone in the field of surface modification due to their widespread biological potential. As their properties are dictated by their structural features, subsequent control thereof using unique fabrication strategies is important. Herein, we report a facile method of precisely creating densely crosslinked polypeptide films with unusually high random coil content through continuous assembly polymerization via reversible addition-fragmentation chain transfer (CAP-RAFT). CAP-RAFT was fundamentally investigated using methacrylated poly-l-lysine (PLLMA) and methacrylated poly-l-glutamic acid (PLGMA). Careful technique refinement resulted in films up to 36.1±1.1 nm thick which could be increased to 94.9±8.2 nm after using this strategy multiple times. PLLMA and PLGMA films were found to have 30-50 % random coil conformations. Degradation by enzymes present during wound healing reveals potential for applications in drug delivery and tissue engineering.
rt-me-fMRI: A task and resting state dataset for real-time, multi-echo fMRI methods development and validation (2020)

Abstract A multi-echo fMRI dataset (N=28 healthy participants) with four task-based and two resting state runs was collected, curated and made available to the community. Its main purpose is to advance the development of methods for real-time multi-echo functional magnetic resonance imaging (rt-me-fMRI) analysis with applications in neurofeedback, real-time quality control, and adaptive paradigms, although the variety of experimental task paradigms supports a multitude of use cases. Tasks include finger tapping, emotional face and shape matching, imagined finger tapping and imagined emotion processing. This work provides a detailed description of the full dataset; methods to collect, prepare, standardize and preprocess it; quality control measures; and data validation measures. A web-based application is provided as a supplementary tool with which to interactively explore, visualize and understand the data and its derivative measures: https://rt-me-fmri.herokuapp.com/ . The dataset itself can be accessed via a data use agreement on DataverseNL at https://dataverse.nl/dataverse/rt-me-fmri . Supporting information and code for reproducibility can be accessed at https://github.com/jsheunis/rt-me-fMRI .
Corticosteroids for preventing graft-versus-host disease (2004)

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To determine the effectiveness of corticosteroids used for the prevention of graft‐versus‐host disease (GvHD) after myeloablative allogenic stem cell transplantation in improving outcome, and also to assess any potential increase of undesired adverse effects (e. g. infections)
Transcription start site profiling of 15 anatomical regions of the Macaca mulatta central nervous system (2017)

Rhesus macaque was the second non-human primate whose genome has been fully sequenced and is one of the most used model organisms to study human biology and disease, thanks to the close evolutionary relationship between the two species. But compared to human, where several previously unknown RNAs have been uncovered, the macaque transcriptome is less studied. Publicly available RNA expression resources for macaque are limited, even for brain, which is highly relevant to study human cognitive abilities. In an effort to complement those resources, FANTOM5 profiled 15 distinct anatomical regions of the aged macaque central nervous system using Cap Analysis of Gene Expression, a high-resolution, annotation-independent technology that allows monitoring of transcription initiation events with high accuracy. We identified 25,869 CAGE peaks, representing bona fide promoters. For each peak we provide detailed annotation, expanding the landscape of 'known' macaque genes, and we show concrete examples on how to use the resulting data. We believe this data represents a useful resource to understand the central nervous system in macaque.
Technical Memorandum Investigation of nonreciprocal Fin-Line devices (1984)

The paper describes a fin-line isolator using a semiconductor layer as an anisotropic media. The spectral-domain method has been extended to suit to our problem. The semiconductor layer is taken into account through its conductivity tensor. Two semiconductors, GaAs and InSb, have been considered in the calculations and experiments. The frequency range considered is the Ka-band (26–40 GHz). It is pointed out that InSb is the best choice.
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals (2022)

Mucins are functionally implicated in a range of human pathologies, including cystic fibrosis, influenza, bacterial endocarditis, gut dysbiosis, and cancer. These observations have motivated the study of mucin biosynthesis as well as the development of strategies for inhibition of mucin glycosylation. Mammalian pathways for mucin catabolism, however, have remained underexplored. The canonical view, derived from analysis of <i>N</i>-glycoproteins in human lysosomal storage disorders, is that glycan degradation and proteolysis occur sequentially. Here, we challenge this view by providing genetic and biochemical evidence supporting mammalian proteolysis of heavily <i>O</i>-glycosylated mucin domains without prior deglycosylation. Using activity screening coupled with mass spectrometry, we ascribed mucin-degrading activity in murine liver to the lysosomal protease cathepsin D. Glycoproteomics of substrates digested with purified human liver lysosomal cathepsin D provided direct evidence for proteolysis within densely <i>O</i>-glycosylated domains. Finally, knockout of cathepsin D in a murine model of the human lysosomal storage disorder neuronal ceroid lipofuscinosis 10 resulted in accumulation of mucins in liver-resident macrophages. Our findings imply that mucin-degrading activity is a component of endogenous pathways for glycoprotein catabolism in mammalian tissues.
Reaction-dispersive proton transport model for negative bias temperature instabilities (2005)

Negative bias temperature instabilities in p-channel metal-oxide-semiconductor field effect transistors are modeled by taking into account the generation of Pb0 centers at the (100)Si∕SiO2 interface, followed by the dispersive transport of protons away from the interface. It is shown that the characteristic time, oxide electric field, and temperature dependence of the threshold voltage shifts observed in these devices can be very well reproduced by the model. The general belief that the transport of positively charged species cannot explain negative bias temperature instabilities thus appears to be incorrect.
For Combat Wounded: Extremity Trauma Therapies From the USAISR (2011)

Abstract : Our focus here is on the future role of the U.S. Army Institute of Surgical Research (USAISR) in reducing the morbidity associated with extremity combat wounds. These wounds are the most frequent and debilitating suffered in Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF). There have been over 40,000 total American combat casualties in OEF and OIF, and of those severely injured on the battlefield, 82% had at least 1 musculoskeletal extremity wound. USAISR is a subordinate command of the U.S. Army Medical Research and Materiel Command (USAMRMC), and since 1947 it has been located at Fort Sam Houston, San Antonio, TX. The Army Burn Unit has been an integral part of USAISR since 1949. Research on trauma and orthopedics has been a part of USAISR's mission since 1970. The USAISR buildings are contiguous with Brooke Army Medical Center (BAMC), which enables the research organization to have a unique in-depth understanding of the combat injuries and the medical challenges faced by the clinicians who treat them. Our mission is to optimize combat casualty care (CCC). In fulfilling this mission, USAISR provides requirements-driven CCC medical solutions and products for injured warriors from self-aid through definitive care. Research is currently organized in 9 Task Areas, i.e., Extremity Trauma and Regenerative Medicine, Damage Control Resuscitation, Pain Control, Advanced Capabilities for Emergency Medical Monitoring, Critical Care Engineering, Clinical Trials, Eye Trauma, Craniomaxillofacial, and Blood (Coagulopathy), to focus on the most critical aspects of combat wound care from the battlefield to upper echelon hospitals. Our core research program is funded and supported by the USAMRMC through 2 complementary Research Area Directorates, CCC and Clinical and Rehabilitative Medicine. We also receive funding from competitive peer-reviewed grant programs and biotechnology companies.
Time course analysis of mechanical ventilation‐induced diaphragm contractile muscle dysfunction in the rat (2014)

Controlled mechanical ventilation (CMV) plays a key role in triggering the impaired diaphragm muscle function and the concomitant delayed weaning from the respirator in critically ill intensive care unit (ICU) patients. To date, experimental and clinical studies have primarily focused on early effects on the diaphragm by CMV, or at specific time points. To improve our understanding of the mechanisms underlying the impaired diaphragm muscle function in response to mechanical ventilation, we have performed time-resolved analyses between 6 h and 14 days using an experimental rat ICU model allowing detailed studies of the diaphragm in response to long-term CMV. A rapid and early decline in maximum muscle fibre force and preceding muscle fibre atrophy was observed in the diaphragm in response to CMV, resulting in an 85% reduction in residual diaphragm fibre function after 9-14 days of CMV. A modest loss of contractile proteins was observed and linked to an early activation of the ubiquitin proteasome pathway, myosin:actin ratios were not affected and the transcriptional regulation of myosin isoforms did not show any dramatic changes during the observation period. Furthermore, small angle X-ray diffraction analyses demonstrate that myosin can bind to actin in an ATP-dependent manner even after 9-14 days of exposure to CMV. Thus, quantitative changes in muscle fibre size and contractile proteins are not the dominating factors underlying the dramatic decline in diaphragm muscle function in response to CMV, in contrast to earlier observations in limb muscles. The observed early loss of subsarcolemmal neuronal nitric oxide synthase activity, onset of oxidative stress, intracellular lipid accumulation and post-translational protein modifications strongly argue for significant qualitative changes in contractile proteins causing the severely impaired residual function in diaphragm fibres after long-term mechanical ventilation. For the first time, the present study demonstrates novel changes in the diaphragm structure/function and underlying mechanisms at the gene, protein and cellular levels in response to CMV at a high temporal resolution ranging from 6 h to 14 days.
Coherent terahertz cyclotron oscillations in a two-dimensional electron gas (2006)

Time-domain THz spectroscopy of a GaAs 2D electron gas in magnetic fields reveals long-lived (~50 ps) coherent oscillations. From the field-dependent oscillation frequency, we attribute these oscillations to the free induction decay of cyclotron resonance.
Direct Oxidative Heck Cyclizations: Intramolecular Fujiwara—Moritani Arylations for the Synthesis of Functionalized Benzofurans and Dihydrobenzofurans. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Femtosecond laser-induced nanostructures in fused silica (2005)

Self-organized nanostructures have been recently observed when femtosecond laser pulses were focused inside fused silica glass. We have shown that these nanostructures extend throughout the focal volume and their order is preserved over macroscopic distances when the focus is scanned. We discuss the present understanding of the formation of the nanostructures including a model based on transient nanoplasmonics. The model predicts the periodicity of nanoplanes to scale as &#955;/2 in the medium. This is experimentally verified at 800 nm and 400 nm light with which we obtain nanoplane spacing of 250 ± 20 nm and 140 ± 20 nm respectively, which scale as predicted. Another requirement of the model is that ionization occurs preferentially at regions that have previously been ionized. This allows an initially inhomogeneous plasma to develop into an ordered nanoplasma array. Using transmission measurements we show that the required "memory" exists in the case of fused silica.
DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma (2018)

Decrease in blood concentration of branched-chain amino acids, especially leucine, is known to promote liver carcinogenesis in patients with chronic liver disease, but the mechanism is unclear. We herein established hepatocellular carcinoma (HCC) cells knocked out for DEPDC5 by using the CRISPR/Cas9 system, and elucidated that cell viability of the DEPDC5 knockout (DEPDC5-KO) cells was higher than that of the DEPDC5 wild-type (DEPDC5-WT) under leucine starvation. Considering that autophagy deficiency might be involved in acquired resistance to leucine deprivation, we observed reduction of LC3-II followed by accumulation of p62 in the DEPDC5-KO, which induced reactive oxygen species (ROS) tolerance. DEPDC5 overexpression suppressed cell proliferation and tumorigenicity in immunocompromised mice, and triggered p62 degradation with increased ROS susceptibility. In clinical specimens of HCC patients, decreased expression of DEPDC5 was positively correlated with p62 overexpression, and the progression-free (PFS) and overall survival (OS) were worse in the DEPDC5-negative cases than in the DEPDC5-positive. Moreover, multivariate analysis demonstrated DEPDC5 was an independent prognostic factor for both PFS and OS. Thus, DEPDC5 inactivation enhanced ROS resistance in HCC under the leucine-depleted conditions of chronic liver disease, contributing to poor patient outcome. It could be a potential target for cancer therapy with oxidative stress control.
Loss of Function of DOCK4 in Myelodysplastic Syndromes Stem Cells is Restored by Inhibitors of DOCK4 Signaling Networks (2019)

LYN kinase and phosphatases SHP1 and SHIP1 are perturbed when DOCK4 expression levels are low. Inhibition of SHP1 promotes erythroid differentiation in healthy HSCs and in -7/(del)7q MDS samples with low DOCK4 expression. Inhibitors of LYN, SHP1 and SHIP1 also abrogated increased migratory properties in HSCs expressing reduced levels of DOCK4.
Additions and Corrections - Multiple Metal-Carbon Bonds. 5. The Reaction of Niobium and Tantalum Neopentylidene Complexes with the Carbonyl Function (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdditions and Corrections - Multiple Metal-Carbon Bonds. 5. The Reaction of Niobium and Tantalum Neopentylidene Complexes with the Carbonyl FunctionRichard SchrockCite this: J. Am. Chem. Soc. 1976, 98, 21, 6766Publication Date (Print):October 1, 1976Publication History Published online9 February 2004Published inissue 1 October 1976https://pubs.acs.org/doi/10.1021/ja00437a616https://doi.org/10.1021/ja00437a616research-articleACS PublicationsRequest reuse permissionsArticle Views41Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Tidal Elevations in the Yellow and East China Seas from a Data-Assimilative, Barotropic Tidal Model. (1997)

Abstract : The Yellow Sea is a very shallow water body with a strong tidal signal. Its strategic importance had led the U.S. Navy to study tidal response in the Yellow and East China Seas using the Colorado University (CU) data assimilative, barotropic tidal model. The CU model has been adapted to accept open-ocean boundary forcing from the Grenoble global tidal data base, which is considered more reliable than tides currently obtained from the CU global tidal model. Furthermore, the number and quality of the data assimilation stations utilized by the CU Yellow Sea model is improved. A detailed, semi-automated procedure for assigning data stations for assimilation into the CU model domain has been developed. Characterization of the tidal elevations in the Yellow and East China Seas from CU model simulations demonstrate that the M2 constituent is the dominant tidal frequency in the Yellow Sea with amplitudes of nearly 2 m along the coast of west Korea. K1 is the most significant diurnal component with amplitudes 1/4 of the M2 tide. A series of experiments is conducted to test the influence of the location of assimilated data on predictions of the dominant tidal constituents M2 and K1. From an analysis of four data station groupings, coastal, shallow, deep, and open boundary located stations, observations located on the continental shelf away from the coastline are most influential in the prediction of primary tides, M2 and K1 in the Yellow Sea. Coastal station data may be more influential in the prediction of nonlinear tidal interactions, since these gauges are often located in harbors or inlets where nonlinear tidal interactions are prominent and wave action may be present.
Water Distribution Systems: A Troubleshooting Manual (1990)

Identification of problems causes of problems solutions of problems analysis and selection.
Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches (2017)

The development of stabilized recombinant HIV envelope trimers that mimic the virion surface molecule has increased enthusiasm for a neutralizing antibody (nAb)-based HIV vaccine. However, there is limited experience with recombinant trimers as immunogens in nonhuman primates, which are typically used as a model for humans. Here, we tested multiple immunogens and immunization strategies head-to-head to determine their impact on the quantity, quality, and kinetics of autologous tier 2 nAb development. A bilateral, adjuvanted, subcutaneous immunization protocol induced reproducible tier 2 nAb responses after only two immunizations 8 weeks apart, and these were further enhanced by a third immunization with BG505 SOSIP trimer. We identified immunogens that minimized non-neutralizing V3 responses and demonstrated that continuous immunogen delivery could enhance nAb responses. nAb responses were strongly associated with germinal center reactions, as assessed by lymph node fine needle aspiration. This study provides a framework for preclinical and clinical vaccine studies targeting nAb elicitation.
Synthesis and antitumor activity of anthracycline disaccharide glycosides containing daunosamine. (1993)

Daunosamine, as its 4-O-acetyl-3-N-trifluoroacetyl glycosyl chloride derivative (1b), has been coupled alpha-L-glycosidically to the 3- and 4-mono-O-acetyl derivatives of L-rhamnal to afford disaccharide glycal derivatives, whose conversion into the corresponding 2-deoxyglycosides by sequential alkoxyiodination-tributylstannane reduction has been evaluated. The sequence successfully demonstrated with the methyl glycosides was successfully extended with daunomycinone as the aglycon, providing a preparative route to 7-O-[3-O-(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)- 2,6-dideoxy-alpha-L-arabino-hexopyranosyl]daunomycinone hydrochloride (15), an analogue of natural anthracycline antibiotics containing daunosamine and a 2,6-dideoxy-L-hexose.
Complications of Deep Brain Stimulation Surgery (2001)

Although technological advances have reduced device-related complications, DBS surgery still carries a significant risk of transient and permanent complications. We report our experience in 86 patients and 149 DBS implants. Patients with Parkinson's disease, essential tremor and dystonia were treated. There were 8 perioperative, 8 postoperative, 9 hardware-related complications and 4 stimulation-induced side effects. Only 5 patients (6%) sustained some persistent neurological sequelae, however, 26 of the 86 patients undergoing 149 DBS implants in this series experienced some untoward event with the procedure. Although there were no fatalities or permanent severe disabilities encountered, it is important to extend the informed consent to include all potential complications.
Audio and ultrasonic frequency response measurements using regularized inverse filtering (2019)

Skyrocketing growth in digital voice communication technology prompts inclusion of ultrasonic microphones in modern smartphones. Inaudible ultrasonic waves provide safe and effective way for ambient intelligence in indoor environments. It is important to measure microphone response over combined audio and ultrasonic range. Conservative measurements based on frequency sweep present signal equalization challenge. Most ultrasonic tweeters produce narrowband ultrasonic tones, while audio speakers resonate below 1 kHz. We present a simple methodology based on emission of specially constructed noise stimulus that overcomes this limitation. The Ole Wolf 25 x16 mm 1 W 8 Ω speaker connected to B&amp;K power amplifier delivered the stimulus. High frequency B&amp;K type 2670 reference microphone was used to record responses at 192 kHz. Experiments were performed in two stages. First, the blue noise was emitted, its response was recorded, and new stimulus with flat spectra between 15–25 kHz was derived using regularized inverse filtering technique. Second, constructed stimulus was emitted and recorded by reference microphone and device under test. The frequency response was derived and found in good agreement with conventional stepped sweep measurements.