gebhart/patrepeval huggingface dataset:
Electron spin resonance and nuclear magnetic resonance study of the reduction of rhodium/titanium dioxide systems at 298 K (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron spin resonance and nuclear magnetic resonance study of the reduction of rhodium/titanium dioxide systems at 298 KStephen J. DeCanio, Joel B. Miller, John B. Michel, and Cecil DybowskiCite this: J. Phys. Chem. 1983, 87, 23, 4619–4622Publication Date (Print):November 1, 1983Publication History Published online1 May 2002Published inissue 1 November 1983https://pubs.acs.org/doi/10.1021/j100246a017https://doi.org/10.1021/j100246a017research-articleACS PublicationsRequest reuse permissionsArticle Views80Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Purinergic Regulation of Sound Transduction and Auditory Neurotransmission (2002)

In the cochlea, extracellular ATP influences the endocochlear potential, micromechanics, and neurotransmission via P2 receptors. Evidence for this arises from studies demonstrating widespread expression of ATP-gated ion channels (assembled from P2X receptor subunits) and G protein-coupled receptors (P2Y receptors). P2X2 receptor subunits are localized to the luminal membranes of epithelial cells and hair cells lining scala media. These ion channels provide a shunt pathway for K+ ion egress. Thus, when noise exposure elevates ATP levels in this cochlear compartment, the K+ conductance through P2X receptors reduces the endocochlear potential. ATP-mediated K+ efflux from scala media is complemented by a P2Y receptor G protein-coupled pathway that provides coincident reduction of K+ transport into scala media from the stria vascularis when autocrine or paracrine ATP signalling is invoked. This purinergic signalling likely provides a basis for a reactive homoeostatic regulatory mechanism limiting cochlear sensitivity under stressor conditions. Elevation of ATP in the perilymphatic compartment under such conditions is also likely to invoke purinergic receptor-mediated changes in supporting cell micromechanics, mediated by Ca2+ influx and gating of Ca2+ stores. Independent of these humoral actions, ATP can be classified as a putative auditory neurotransmitter based on the localization of P2X receptors at the spiral ganglion neuron-hair cell synapse, and functional verification of ATP-gated currents in spiral ganglion neurons in situ. Expression of P2X receptors by type II spiral ganglion neurons supports a role for ATP as a transmitter encoding the dynamic state of the cochlear amplifier.
The Pattern Of Cell Survival In The Pig Liver Following One Freeze-thaw Cryosurgery Cycle (2022)

BACKGROUND: It is well established that in cryosurgery some cells can survive one freeze thaw cycle and that surviving cells are found at the margin of the frozen lesion. Numerous techniques are being developed to ensure the survival of frozen cells to the margin of the frozen region. OBJECTIVE: We thought that it would be of fundamental interest to observe the pattern of cell survival in a liver treated with one freeze-thaw cycle. MATERIALS AND METHODS: We performed six ultrasound-guided single freeze-thaw cryosurgery procedures on the liver of four Landrace pigs, using two cryosurgery probes separated by 25 mm inserted in parallel. Treated organs were removed 24 hours after the cryosurgery and processed for histology with hematoxylin and eosin. The tissues were analyzed with a digital slice scanner. RESULTS: We found an unexpected pattern of cell survival; sheets of live cells, about 200 μm in width, that follow the network of interlobular connective tissue septae to a distance of several millimeter from the outer edge of the one freeze-thaw cycle cryosurgery treated lesion. The sheets of live cells surround lobule cores that have undergone complete coagulative necrosis. In addition, larger blood vessels, as far as 5 mm from the outer rim of the treated lesion, have a major and complex effect on cell survival with large areas of completely necrotic and completely alive cells intermixed. CONCLUSION: This study may have value as a baseline for developing new cryosurgery protocols designed to ablate cells to the margin of the frozen lesion.
Characterization of the SOD1-G93A mouse model of Amyotrophic lateral sclerosis and a promising treatment for the disease (2018)

Background
A declarative approach to event-handling in visual programming languages (2003)

The authors address the question of event-handling for declarative visual languages. In the approach presented, system-level, interactive, and user-defined events are fully-supported, while still maintaining the property of referential transparency. An approach to time termed temporal assignment provides a unifying mechanism for events to be defined as ordinary sequences of values, and conversely for ordinary sequences of values to be defined as events. This allows event-handling without additional concepts, and in particular provides a natural means for the user to define higher-level events of any kind.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Comparison of High Order Modulation Formats for 40Gb/s and 100Gb/s (Invited) (2009)

Modulation formats for 40 and 100 Gb/s transmission are compared based on OSNR tolerance. Implementation considerations are highlighted. Propagation penalty as a function of optical dispersion compensation is studied for 112 Gb/s DP-QPSK.
ChemInform Abstract: EIN STEREOCHEMISCHER RK.‐ABLAUF MIT CHIRALEM PHOSPHOR (1971)

Abstract In der Menthyl‐ und der Cholesterylreihe (I) werden verschiedene stereospezifisch ablaufende Reaktionen vorgenommen, die durchweg unter völliger Erhaltung der Konfiguration ablaufen.
Size and Surface Effects of Silicon Nanocrystals in Graphene Aerogel Composite Anodes for Lithium Ion Batteries (2018)

Silicon is recognized as a promising anode material for high-performance lithium ion batteries due to its high theoretical specific capacity and elemental abundance. Challenges related to the low electrical conductivity of Si and large volume changes during the lithiation/delithiation cycles, as well as the low rate of lithium diffusion in silicon anodes, hinder practical applications. To provide fundamental insights into these issues, silicon nanocrystal/graphene aerogel nanocomposites were synthesized by combining undecanoic acid-functionalized silicon nanocrystals of various sizes (SiX-COOH, where X represents the nanocrystal diameter of 3, 5, 8, and 15 nm) with conductive mesoporous graphene aerogels (GAs). The silicon nanocrystals are evenly dispersed throughout the graphene aerogel as shown by energy-dispersive X-ray (EDX) mapping. In terms of electrochemical performance, SiX-COOH/GA nanocomposites demonstrated a clear dependence on the size of the embedded silicon nanocrystals, with the composites comprising the larger silicon nanocrystals showing a higher initial capacity but accompanied by rapid decay of capacity retention over 100 cycles. To study the effect of thermal processing on the electrochemical performance, SiX-COOH/GA nanocomposites were annealed at 600 °C to yield annealed SiX/GA nanocomposites. The annealed nanocomposite composed of the smallest silicon nanocrystals, Si3/GA, exhibits a stable specific capacity of ∼1100 mAh/g and capacity retention of over 90% after 500 cycles when tested at a current density of 400 mA/g.
A new class of sequential and adaptive algorithms with application to noise cancellation (2003)

A class of sequential and adaptive algorithms for parameter estimation are presented that are based on the iterative estimate-maximize (EM) algorithm. In some cases sequential algorithms are derived that perform an exact EM step in each recursion; an example for these cases is given for the linear least-squares problem. In general, however, it is necessary to approximate the EM iteration in order to develop sequential algorithms. The application of this class of algorithms to the two-microphone noise cancellation problem is described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Bcl-2+ tonsillar plasma cells are rescued from apoptosis by bone marrow fibroblasts. (1996)

Plasma cells represent the final stage of B lymphocyte differentiation. Most plasma cells in secondary lymphoid tissues live for a few days, whereas those in the lamina propria of mucosa and in bone marrow live for several weeks. To investigate the regulation of human plasma cell survival, plasma cells were isolated from tonsils according to high CD38 and low CD20 expression. Tonsillar plasma cells express CD9, CD19, CD24, CD37, CD40, CD74, and HLA-DR, but not CD10, HLA-DQ, CD28, CD56, and Fas/CD95. Although plasma cells express intracytoplasmic Bcl-2, they undergo swift apoptosis in vitro and do not respond to CD40 triggering. Bone marrow fibroblasts and rheumatoid synoviocytes, however, prevented plasma cells from undergoing apoptosis in a contact-dependent fashion. These data indicate that fibroblasts may form a microenvironment favorable for plasma cell survival under normal and pathological conditions.
Characterization of deposits in patients with calcific tendinopathy of the supraspinatus. Role of phytate and osteopontin (2014)

Calcific tendinopathy of the tendons of the rotator cuff is common in adults. These calcifications tend to be reabsorbed after a period of acute pain. This study evaluated the morphologic characteristics of calcific deposits and the participation of phytate and osteopontin (OPN) in their development. Calcific deposits were removed from 21 patients with calcific tendinopathy by ultrasound-guided needle puncture under local anesthesia. The removed deposits were evaluated by scanning electron microscopy, X-ray diffraction and Fourier transform infrared spectroscopy. The amounts of calcium and phosphorus in the deposits were semi-quantitatively determined by energy dispersive X-ray analysis. Phytate was determined in 2 h urine samples, and OPN was extracted from a pool of deposits. The calcific deposits consisted of amorphous and poorly crystalline carbonated hydroxyapatite containing molecular water and organic matter. OPN was associated with the hydroxyapatite deposits. Phytate concentrations were significantly lower in the urine of patients with calcific tendinopathy than in healthy controls. The deficit in crystallization inhibitors such as phytate, and the presence of regulators such as OPN, may play important roles in the development of calcific tendinopathy.
Abstract PR15: SUZ12: A novel tumor suppressor and potential biomarker for efficacy of BRD4 inhibition (2013)

Abstract Patients with the familial cancer syndrome neurofibromatosis type I possess mutations in the NF1 tumor suppressor gene, which encodes a RasGAP. However a subset of patients carry a larger deletion that encompasses NF1 and the surrounding 13 genes. These patients develop hundreds of benign nervous system tumors, are at much higher risk for developing malignancies, and exhibit specific developmental defects. Therefore we hypothesized that a cooperating tumor suppressor must lie within this region. Notably, this entire region is frequently deleted in in a number of different cancers, including glioblastoma (GBM). To identify a potential cooperating tumor suppressor we analyzed a large number of NF1-associated malignancies by array CGH and detected homozygous loss of SUZ12, a member of the PRC2 repressor complex. Subsequent mutation analysis showed that SUZ12 was homozygously inactivated in a large subset of MPNSTs. Importantly, reintroduction of SUZ12 in SUZ12 deficient Malignant Peripheral Nerve Sheath tumors (MPNST) cell lines restored the function of the PRC2 complex and induced cell death. Conversely, RNAi mediated inactivation of SUZ12 significantly enhanced the tumorigenic properties of NF1-deficient GBMs. Additionally, we found that mice carrying compound heterozygous mutations in Nf1 and Suz12 developed a variety of tumor types and had a marked decrease in overall survival. As expected, knockdown of SUZ12 dramatically decreased the global H3K27 tri-methylation (repressive mark) and increased the global H3K27 acetylation (activation mark). This suggests that the pathogenic effect of SUZ12-loss is, at least in part, caused by an aberrant activation of genes due to an increase in H3K27 acetylation. Interestingly this H3K27 acetylation mark is read by BRD4, suggesting that inhibition of BRD4 might decrease the expression of critical targets. In vitro and in vivo studies indeed confirmed a hypersensitivity to BRD4 inhibition of cell lines and primary tumors lacking SUZ12. Additionally our preliminary data show an inverse correlation between the H3K27 tri-methylation level and the response to treatment with the BRD4 inhibitor JQ1, suggesting that SUZ12 levels, and thus H3K27 tri-methylation status, could be used as a biomarker. In conclusion, we showed that SUZ12 is a tumor suppressor in a number of different cancers, including MPNSTs and gliomas. These tumors are exquisitely sensitive to inhibition of BRD4. Loss of SUZ12 leads to complete ablation of the H3K27 tri-methylation mark, which could serve as a biomarker for treatment with the BRD4 inhibitor JQ1. This abstract is also presented as Poster B51. Citation Format: Thomas De Raedt, Eline Beert, Eric Pasmant, James E. Bradner, Pierre Wolkenstein, Eric Legius, Karen Cichowski. SUZ12: A novel tumor suppressor and potential biomarker for efficacy of BRD4 inhibition. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Jun 19-22, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2013;73(13 Suppl):Abstract nr PR15.
Proceedings of the 2nd Conference on Wireless Health (2011)

This year has brought remarkable new progress in the development of the Wireless Health field. The capability for continuous monitoring of physiological status and detailed behavior combined with individualized guidance is now having an early impact on healthcare delivery. The current time is historic in that it is now clear that the outcomes of treatment, the decisions regarding healthcare pathways, the effectiveness and accuracy of clinical trials will all be affected by this new capability and forever change healthcare, medical research and education, and related fields.

We are very pleased to welcome you to the second in the series of Wireless Health conferences (Wireless Health 2011) and their Conference Proceedings. This year brings an exceptional set of contributed papers on the leading research. Also, the conference keynote addresses describe the most important new initiatives in wireless health medical research, industry, and government. Panel presentations include discussion of primary breakthroughs in wireless health from the reduction of hospital treatment readmission rate to the description of wireless health in the nation's automotive vehicles.

The Wireless Health series has been created to be the primary annual single-track conference series convening the vanguard international research communities in Wireless Health technology and medical research. As in the previous year, Wireless Health 2011 is established in-cooperation with the Association for Computing Machinery (ACM).
Effects of Probiotic Lactobacillus Paracasei Treatment on the Host Gut Tissue Metabolic Profiles Probed via Magic-Angle-Spinning NMR Spectroscopy (2007)

We have used a simplified gnotobiotic mouse model to evaluate the effects of single bacterial species, Lactobacillus paracasei NCC2461, on the metabolic profiles of intact intestinal tissues using high-resolution magic-angle-spinning 1H NMR spectroscopy (HRMAS). A total of 24 female gnotobiotic mice were divided into three groups: a control group supplemented with water and two groups supplemented with either live L. paracasei or a gamma-irradiated equivalent. HRMAS was used to characterize the biochemical components of intact epithelial tissues from the duodenum, jejunum, ileum, proximal, and distal colons in all animals and data were analyzed using chemometrics. Variations in relative concentrations of amino acids, anti-oxidant, and creatine were observed relating to different physiological properties in each intestinal tissue. Metabolic characteristics of lipogenesis and fat storage were observed in the jejunum and colon. Colonization with live L. paracasei induced region-dependent changes in the metabolic profiles of all intestinal tissues, except for the colon, consistent with modulation of intestinal digestion, absorption of nutrients, energy metabolism, lipid synthesis and protective functions. Ingestion of gamma-irradiated bacteria produced no effects on the observed metabolic profiles. 1H MAS NMR spectroscopy was able to generate characteristic metabolic signatures reflecting the structure and function of intestinal tissues. These signals acted as reference profiles with which to compare changes in response to gut microbiota manipulation at the tissue level as demonstrated by ingestion of a bacterial probiotic.
ChemInform Abstract: Organocatalytic Sequential α‐Amination/Corey—Chaykovsky Reaction of Aldehydes: A High Yield Synthesis of 4‐Hydroxypyrazolidine Derivatives. (2012)

Abstract The title reaction allows a new and highly stereoselective access to the target compounds; epoxides are not obtained.
Characterization of Wavelength Swept Laser with a Scanning Frequency at 1300 nm (2009)

광섬유 일체형으로 된 파브리-페롯 가변 필터를 레이저 공진기에 삽입하고, 1300 nm 대역의 반도체 광 증폭기를 이득매질로 이용하여 링 공진기 형태의 파장 훑음 레이저를 구현하였다. 파장 훑음 레이저의 훑음 주파수에 따른 레이저 출력 특성을 시간영역과 파장영역에서 분석하였다. 파장 훑음 주파수가 증가하면 레이저 출력이 급격하게 줄어들고, 훑음 반치폭도 감소한다. 또한 훑음 주파수 증가에 따라 전방 훑음과 후방 훑음의 광 세기가 비대칭으로 나타나며, 실제 응용 시스템에 적용할 수 있는 제한요소로 작용한다. We demonstrate a ring type wavelength swept laser incorporating a fiber Fabry-Perot tunable filter in a laser cavity using 1300 nm semiconductor optical amplifier as a gain medium. The output characteristics of the wavelength swept laser according to the applied scanning frequencies are analyzed in the temporal and spectral domain. The output of the wavelength swept laser decreases dramatically as the scanning frequency increases. And there is a significant peak power imbalance between the forward scan and the backward scan as the scanning frequency increases. Its use in practical applications might be limited.
Waveguide Evanescent Field Spectroscopy of Trace Gases (2013)

We detect trace gases at ppb levels using evanescent-field absorption spectroscopy in microring resonators coated with sorbent polymers. The overtone spectra derive from mid-infrared resonances that provide a signature of analyte toxicity.
ProstaCaid Induces G2/M Cell Cycle Arrest and Apoptosis in Human and Mouse Androgen-Dependent and-Independent Prostate Cancer Cells (2010)

The anticancer effects of ProstaCaid, a novel integrative blend of vitamins, minerals, multiherb extracts, and derivatives, were tested in human and mouse androgen-dependent (AD) and -independent (AI) prostate cancer cell lines. ProstaCaid shows growth inhibitory effects on both human and mouse AD prostate cancer cells (LNCaP and CASP 2.1) and AI prostate cancer cells (PC3 and CASP 1.1) in a dose-/time-dependent manner. Consistently, long-term treatment with ProstaCaid also reduced colony formation capacities of prostate cancer cells. Flow cytometry assays revealed that ProstaCaid induces G2/M arrest and apoptosis in LNCaP and PC3 cells after 72 hours of treatment. Immunoblotting assay demonstrated that 25 microg/mL of ProstaCaid treatment resulted in (1) the reduction of cyclin D1, cyclin B1, and Cdc2 expression in a time-dependent way; (2) increase in p21(WAF1/Cip1) as early as 12 hours after the treatments in PC3 cells and reduction to base line at the 72-hour time point; and (3) repression of Bcl-2, BclxL, and induction of Bim as well as the cleavages of caspase-3 and poly(ADP-ribose) polymerase (PARP) at 72 hours of treatment, suggesting caspase-3-dependent apoptosis. Moreover, ProstaCaid suppressed activation of AKT and MAPK signaling pathways in PC3 and LNCaP cells by reducing phosphorylation levels of AKT, its downstream target S6 ribosomal protein and GSK3beta, and ERK1/2, respectively. In summary, these findings strongly suggest that ProstaCaid may be a potential chemopreventive and therapeutic agent for both AD and, more importantly, AI prostate cancer.
Benzofurocarbazole and benzothienocarbazole as donors for improved quantum efficiency in blue thermally activated delayed fluorescent devices (2015)

Benzofurocarbazole and benzothienocarbazole were used as electron donors of thermally activated delayed fluorescence (TADF) emitters and the performances of the TADF devices were examined. The benzofurocarbazole and benzothienocarbazole donor moieties were better than carbazole as the electron donors of the TADF emitters.
Retrospective Analysis of the Treatment Outcome in Myeloid Leukemia of Down Syndrome in Polish Pediatric Leukemia and Lymphoma Study Group From 2005 to 2019 (2020)

<b>Background:</b> Children with Down syndrome (DS) have increased risk of myeloid leukemia (ML), but specific treatment protocols ensure excellent outcome. This study was a retrospective analysis of the treatment results and genetic characteristics of ML of DS (ML-DS) in Poland from 2005 to 2019. <b>Methods:</b> All 54 patients with ML-DS registered in the Polish Pediatric Leukemia and Lymphoma Study Group in analyzed period were enrolled to the study. There were 34 children treated with Acute Myeloid Leukemia-Berlin-Frankfurt-Munster 2004 Interim Protocol (group I) and 20 patients treated with ML-DS 2006 Protocol (group II). In the first protocol, there was reduction of the antracyclines doses and intrathecal treatment for ML-DS compared to non-DS patients. In the second protocol, further reduction of the treatment was introduced (omission of etoposide in the last cycle, no maintenance therapy). <b>Results:</b> Probabilities of 5-year overall survival (OS), event-free survival (EFS), and relapse-free survival in the whole analyzed group were 0.85 ± 0.05, 0.83 ± 0.05, and 0.97 ± 0.03, respectively. No significant differences were found between two protocols in the terms of OS and EFS (0.79 ± 0.07 vs. 0.95 ± 0.05, <i>p</i> = 0.14, and 0.76 ± 0.07 vs. 0.95 ± 0.05, <i>p</i> = 0.12, respectively). All deaths were caused by the treatment-related toxicities. Reduction of the treatment-related mortality was noticed (20% in group I and 5% in group II). The only one relapse in the whole cohort occurred in the patient from group I, older than 4 years, without <i>GATA1</i> gene mutation. He was treated successfully with IdaFLA cycle followed by hematopoietic stem cell transplantation from matched sibling donor. No significant prognostic factor was found in the study group probably due to low number of patients in the subgroups. <b>Conclusions:</b> The study confirms that the reduced intensity protocols are very effective in ML-DS patients. The only cause of deaths was toxicities; however, systematic decrease of the treatment-related mortality was noticed.