gebhart/patrepeval huggingface dataset:
Low complexity and high order two-dimensional non-uniform constellations for high capacity broadcasting systems (2016)

Non uniform constellations have been recently included in the new terrestrial broadcasting system ATSC 3.0, providing better performance than the uniform ones. However, for high order constellations, the complexity in the demapper grows as the number of constellation points do, being necessary to reduce the number of degrees of freedom in the constellation design process. The goal of this paper is to present a set of optimal high order non uniform constellations which provide higher gain than the ones proposed for the ATSC 3.0 system with low demapping complexity.
Introducing pharmacogenetic testing with clinical decision support into primary care: a feasibility study (2016)

Physicians and pharmacists can collect saliva samples of sufficient quantity and quality for DNA extraction, purification and genotyping. A clinical decision support system with integrated data from pharmacogenetic tests may enable personalized prescribing within primary care. <b>Trial registration:</b> ClinicalTrials.gov, NCT02383290.
Effects of a second-generation human anti-ErbB2 ImmunoRNase on trastuzumab-resistant tumors and cardiac cells (2014)

The inhibition of ErbB2 by the use of human antibodies can be a valuable strategy for the treatment of breast and gastric cancer. Trastuzumab, a humanized anti-ErbB2 antibody in clinical use, is effective but can engender resistance as well as cardiotoxicity. ImmunoRNases, made up of a human anti-ErbB2 scFv and human pancreatic ribonucleases (HP-RNases), have been engineered to overcome the limits of other immunotoxins, such as immunogenicity and nonspecific toxicity. Here, we report that a novel anti-ErbB2 immunoRNase, called Erb-HPDDADD-RNase, obtained by fusing Erbicin, a human ErbB2-directed scFv, with an HP-RNase variant that resists the cytosolic inhibitor protein, binds with high affinity to a panel of ErbB2-positive gastric tumor cells and inhibits their growth more than does the parental immunoRNase, which is not resistant to the inhibitor. Moreover, Erb-HP-DDADD-RNase is endowed with antiproliferative activity for trastuzumab-resistant cancer cells both in vitro and in vivo that is more potent than that of the parental immunoRNase. Importantly, Erb-HP-DDADD-RNase does not show cardiotoxic effects in vitro on human cardiomyocytes and does not impair cardiac function in a mouse model. Thus, Erb-HP-DDADD-RNase could fulfil the therapeutic need of cancer patients ineligible for trastuzumab treatment due to primary or acquired trastuzumab resistance or to cardiac dysfunction.
Analysis of Two-Component Systems in Group B Streptococcus Shows That RgfAC and the Novel FspSR Modulate Virulence and Bacterial Fitness (2014)

Two-component systems have been evolved by bacteria to detect environmental changes, and they play key roles in pathogenicity. A comprehensive analysis of TCS in GBS has not been performed previously. In this work, we classify 21 TCS and present evidence for the involvement of two specific TCS in GBS virulence and colonization in vivo. Although pinpointing specific TCS stimuli is notoriously difficult, we used a combination of techniques to identify two systems with different effects on GBS pathogenesis. For one of the systems, we propose that fructose-6-phosphate, a metabolite in glycolysis, is sufficient to induce a regulatory response involving a sugar transport system. Our catalogue and classification of TCS may guide further studies into the role of TCS in GBS pathogenicity and biology.
Periodically-segmented tapered waveguide for mode-size transformation and fundamental mode excitation (1996)

Transformation of modal properties through axial tapering of the structure of a dielectric waveguide is useful in several contexts. Mode size transformation with a tapered waveguide allows independent optimization of the mode size in different portions of a waveguide to simultaneously achieve effective input and output coupling and for efficient performance of active or electrooptic devices. An adiabatic taper from a single to a multimode waveguide also allows robust coupling into the fundamental mode of a multimode waveguide, important in certain types of nonlinear waveguide devices, such as difference frequency generators, that involve interactions between modes at widely disparate wavelengths. Periodically-segmented waveguides (PSWs), investigated both theoretically1,2,3 and experimentally4,5 in the literature, allow independent control over vertical and lateral confinement, and thus can be used to tailor the size and shape of waveguide modes. In this paper we report tapers in annealed-proton-exchanged (APE) waveguides in LiNbO3 through the use of segmented waveguides with axially varying duty cycle.
Diuretics and mortality in acute renal failure* (2004)

Diuretics are commonly prescribed in critically ill patients with acute renal failure, and their use is not associated with higher mortality. There is full equipoise for a randomized controlled trial of diuretics in critically ill patients with renal dysfunction.
Reasons for Taking a Course About the Gifted. (1975)

ABSTRACT Investigated with 110 university students taking an introductory gifted education course were the relationships between sex, three instructional levels (elementary, secondary, and special education), and reasons for taking the course. Data was collected over a 4-year period. Six reasons for taking the course were identified, which included that some students were curious about the gifted and creative; and that the major portion of the teachers were from elementary education and female. (SBH)
ChemInform Abstract: Synthesis of Compounds Active Against HIV: Preparation of 6′‐Fluorocarbocyclic AZT (AZT = 3′‐Deoxy‐3′‐azidothymidine). (1990)

Abstract Treatment of the tricyclic bromo ketone (I) with triethylamine trihydrofluoride results in rearrangement and fluorination to give the bicyclic dihalo ketone (II) which is converted into the aminocyclopentane (VIII) via the lactone (IV).
Does carotid intima media thickness indicate coronary atherosclerosis? (2002)

Increased carotid intima media thickness (IMT) is relatively simple, inexpensive, and reproducible noninvasive marker of global atherosclerotic disease. It is a frequently used experimental tool in epidemiologic studies to identify and follow cardiovascular disease. There is evidence that early detection of atherosclerotic disease processes and subsequent therapeutic interventions significantly alter the natural course of the disease. Several large prospective studies have evaluated the usefulness of ultrasonographic measurement of IMT and have demonstrated its role in predicting future cardiovascular events. This article will focus on the relation between carotid artery IMT and coronary heart disease, and its utility and limitations in predicting cardiovascular events.
Expression of Phosphophoryn Is Sufficient for the Induction of Matrix Mineralization by Mammalian Cells (2011)

Mineralized tissues such as dentin and bone assemble extracellular matrices uniquely rich in a variety of acidic phosphoproteins. Although these proteins are presumed to play a role in the process of biomineralization, key questions regarding the nature of their contributions remain unanswered. First, it is not known whether highly phosphorylated proteins alone can induce matrix mineralization, or whether this activity requires the involvement of other bone/dentin non-collagenous proteins. Second, it remains to be established whether the protein kinases that phosphorylate these acidic proteins are unique to cells responsible for producing mineralized tissues. To begin to address these questions, we consider the case of phosphophoryn (PP), due to its high content of phosphate, high affinity for Ca(2+), and its potential role in hydroxyapatite nucleation. We have created a model system of biomineralization in a cellular environment by expressing PP in NIH3T3 fibroblasts (which do not produce a mineralized matrix); as a positive control, PP was expressed in MC3T3-E1 osteoblastic cells, which normally mineralize their matrices. We show that expression of PP in NIH3T3 cells is sufficient for the induction of matrix mineralization. In addition, assessment of the phosphorylation status of PP in these cells reveals that the transfected NIH3T3 cells are able to phosphorylate PP. We suggest that the phosphorylation of PP is essential for mineral formation. The principle goal of this study is to enrich the current knowledge of mineralized tissue phosphorylation events by analyzing them in the context of a complete cellular environment.
The central body of the cyanelles of Cyanophora paradoxa: a eukaryotic carboxysome? (2005)

The cyanelles of the glaucocystophyte Cyanophora paradoxa combine two prokaryotic features not found in other phototrophic eukaryotes: a peptidoglycan wall and a putative carboxysome. Both of them would be indispensable when a inorganic carbon concentrating mechanism involving high accumulation of bicarbonate in the cyanelle stroma is assumed. Two approaches were used. (i) An expressed sequence tag library was generated allowing access to interesting genes and microarray technology. Hybridization of the microarrays to RNA from cells grown at high and low CO 2 yielded 97 genes that were upregulated under CO 2 stress whereas 87 genes were found to be downregulated. (ii) Cyanelle central bodies were isolated and protein components other than Rubisco were investigated by mass spectrometry. So far, mass spectrometric analysis of putative carboxysomal proteins yielded only sequences with no match in the databases. Rubisco activase could be shown via in vitro import and Western blotting to be copackaged with Rubisco in isolated purified central bodies. While our data support the presence of an inorganic carbon concentrating mechanism in cyanelles, they do not allow us to distinguish the microcompartment as a carboxysome or pyrenoid.Key words: Cyanophora paradoxa, cyanelles, carboxysome, Rubisco activase, carbon-concentrating mechanism, microarrays.
Improved Method To Track Chlorophyll Degradation (2001)

An analytical method capable of identifying >30 chlorophyll-related compounds in plant extracts has been developed. The method employs liquid chromatography coupled to UV-vis, MS, and MS/MS detection. It can be applied without modification to analyze natural chlorophyll degradation products and other metalloporphyrines. It was successfully applied to identify chlorophyll derivatives found in rehydrated spinach powder and conventionally canned and Veri-Green-processed beans. In the Veri-Green-processed beans several degradation products were identified that are zinc-containing analogues to the chlorophyll derivatives found in vegetables after conventional canning. They have been characterized by liquid chromatography and mass spectrometry.
Self-Healing, Improved Efficiency Solid State Rechargeable Li/I 2 Based Battery (2021)

Solid state electrolytes are receiving significant interest due to the prospect of improved safety, however, addressing the incidence and consequence of internal short circuits remains an important issue. Herein, a battery based on a LiI-LiI(HPN)<sub>2</sub> solid state electrolyte demonstrated self-healing after internal shorting where the cells recovered and continued to cycle effectively. The functional rechargeable electrochemistry of the self-forming Li/I<sub>2</sub>-based battery was investigated through interfacial modification by inclusion of Li metal (at the negative interface), and/or fabricated carbon nanotube substrates at the positive interface. A cell design with lithium metal at the negative and a carbon substrate at the positive interface produced Coulombic efficiencies > 90% over 60 cycles. Finally, the beneficial effects of moderately elevated temperature were established where a 10°C temperature increase led to ~5X lower resistance.
Wireless Channel Prediction in Partially Observed Environments (2022)

Site-specific radio frequency (RF) propagation prediction increasingly relies on models built from visual data such as cameras and LIDAR sensors. When operating in dynamic settings, the environment may only be partially observed. This paper introduces a method to extract statistical channel models, given partial observations of the surrounding environment. We propose a simple heuristic algorithm that performs ray tracing on the partial environment and then uses machine-learning trained predictors to estimate the channel and its uncertainty from features extracted from the partial ray tracing results. It is shown that the proposed method can interpolate between fully statistical models when no partial information is available and fully deterministic models when the environment is completely observed. The method can also capture the degree of uncertainty of the propagation predictions depending on the amount of region that has been explored. The methodology is demonstrated in a robotic navigation application simulated on a set of indoor maps with detailed models constructed using state-of-the-art navigation, simultaneous localization and mapping (SLAM), and computer vision methods.
Continuing Education Course #1 (2010)

The continuing education course "Non-Invasive Imaging as a Problem-Solving Tool and Translational Biomarker Strategy in Toxicologic Pathology" provided a thorough overview of commonly used imaging modalities and the logistics required for integration of small animal imaging into toxicologic pathology. Non-invasive imaging (NIN) is gaining acceptance as an important modality in toxicologic pathology. This technology allows nonterminal, time-course evaluation of functional and morphologic endpoints and can be used to translate biomarkers between preclinical animal models and human patients. NIN can support drug development as well as basic research in academic or industrial environments. An initial overview of theoretical principles was followed by focused presentations on magnetic resonance imaging (MRI)/magnetic resonance microscopy (MRM), positron emission tomography (PET)/single proton emission computed tomography (SPECT), ultrasonography (US, primarily focused on echocardiography), optical (bioluminescent) imaging, and computed tomography (CT). The choice of imaging modality will depend on the research question and the needed resolution.
ChemInform Abstract: Chemoselective Methylenation with a Methylenedianion Synthon. (1986)

Abstract Die Systeme CH2I2/Zn/Ti(OiPr)4 und CH2I2/Zn/AlMe3 stellen wirksame selektive Methylenierungsmittel für Aldehyde dar.
Simple Pixel Structure Using Video Data Correction Method for Nonuniform Electrical Characteristics of Polycrystalline Silicon Thin-Film Transistors and Differential Aging Phenomenon of Organic Light-Emitting Diodes (2010)

A simple pixel structure using a video data correction method is proposed to compensate for electrical characteristic variations of driving thin-film transistors (TFTs) and the degradation of organic light-emitting diodes (OLEDs) in active-matrix OLED (AMOLED) displays. The proposed method senses the electrical characteristic variations of TFTs and OLEDs and stores them in external memory. The nonuniform emission current of TFTs and the aging of OLEDs are corrected by modulating video data using the stored data. Experimental results show that the emission current error due to electrical characteristic variation of driving TFTs is in the range from -63.1 to 61.4% without compensation, but is decreased to the range from -1.9 to 1.9% with the proposed correction method. The luminance error due to the degradation of an OLED is less than 1.8% when the proposed correction method is used for a 50% degraded OLED.
Reducing synchronization overhead in parallel simulation (1996)

Synchronization is often the dominant cost in conservative parallel simulation, particularly in simulations of parallel computers, in which low-latency simulated communication requires frequent synchronization. We present and evaluate LOCAL BARRIERS and PREDICTIVE BARRIER SCHEDULING, two techniques for reducing synchronization overhead in the simulation of message-passing multicomputers. Local barriers use nearest-neighbor synchronization to reduce waiting time at synchronization points. Predictive barrier scheduling, a novel technique that schedules synchronizations using both compile-time and runtime analysis, reduces the frequency of synchronization operations. In contrast to other work in this area, both techniques reduce synchronization overhead without decreasing the accuracy of network simulation. These techniques were evaluated by comparing their performance to that of periodic global synchronization. Experiments show that local barriers improve performance by up to 24% for communication-bound applications, while predictive barrier scheduling improves performance by up to 65% for applications with long local computation phases. Because the two techniques are complementary, we advocate a combined approach. This work was done in the context of PARALLEL PROTEUS, a new parallel simulator of message-passing multicomputers.
Isolation and characterization of a maintenance DNA-methyltransferase gene from peach (Prunus persica [L.] Batsch): transcript localization in vegetative and reproductive meristems of triple buds (2003)

A cDNA coding for a DNA (cytosine-5)-methyltransferase (METase) was isolated from peach (Prunus persica [L.] Batsch) and the corresponding gene designated as PpMETI. The latter encoded a predicted polypeptide of 1564 amino acid residues and harboured all the functional domains conserved in the maintenance METases group type I. PpMETI was a single copy in the cultivar Chiripa which was used as a model in the present study. Expression analyses revealed that PpMETI transcripts were more abundant in tissues with actively proliferating cells such as apical tips, uncurled leaves, elongating herbaceous stems, and small immature fruits. Peach plants bear bud clusters (triads or triple buds), consisting of two lateral and one central bud with floral and vegetative fates, respectively. PpMETI in situ hybridization was performed in triple buds during their entire developmental cycle. High and low levels of PpMETI transcript were related to burst and quiescence of vegetative growth, respectively. Message localization distinguished lateral from central buds during the meristem switch to the floral phase. In fact, the PpMETI message was abundant in the L1 layer of protruding domes, a morphological trait marking the beginning of floral transition. The PpMETI transcript was also monitored during organ flower formation. Altogether, these data suggest a relationship between DNA replication and PpMETI gene expression.
Spreading Of Swirling Double–Concentric Jets At Low And High Pulsation Intensities (2013)

The spreading characteristics of acoustically excited swirling double-concentric jets were studied experimentally. The central jet was acoustically excited at low and high pulsation intensities. A smoke wire flow visualization and a hot-wire anemometer velocity measurement results show that excitation forces a vortex ring to roll-up from the edge of the central tube during each excitation period. At low pulsation intensities, the vortex ring evolves downstream, and eventually breaks up into turbulent eddies. At high pulsation intensities, the primary vortex ring evolves and a series of trailing vortex rings form during the same period of excitation. The trailing vortex rings accelerate while evolving downstream and overtake the primary vortex ring within the same cycle. In the process, the primary vortex ring becomes unstable and breaks up early. The effect of the fast traveling trailing vortex rings combined with the swirl motion of the annular flow improve jet spreading compared with the naturally evolving jets.
Structure–activity relationships and cellular mechanism of action of small molecules that enhance the delivery of oligonucleotides (2018)

The pharmacological effects of antisense and siRNA oligonucleotides are hindered by the tendency of these molecules to become entrapped in endomembrane compartments thus failing to reach their targets in the cytosol or nucleus. We have previously used high throughput screening to identify small molecules that enhance the escape of oligonucleotides from intracellular membrane compartments and have termed such molecules OECs (oligonucleotide enhancing compounds). Here, we report on the structure-activity relationships of a family of OECs that are analogs of a hit that emerged from our original screen. These studies demonstrate key roles for the lipophilic aromatic groups, the tertiary nitrogen, and the carbamate moiety of the parent compound. We have also investigated the intracellular site of action of the OECs and have shown that activity is due to the release of oligonucleotides from intermediate endosomal compartments rather than from early endosomes or from highly acidic downstream compartments. At high concentrations of OECs toxicity occurs in a manner that is independent of caspases or of lysosomal cathepsins but instead involves increased plasma membrane permeability. Thus, in addition to describing specific characteristics of this family of OECs, the current study provides insights into basic mechanisms of oligonucleotide trafficking and their implications for oligonucleotide delivery.
Evaluation of classical NSAIDs on COX-1 and COX-2 purified enzymes and prognosis of their effects on physiological responses (1999)

peer reviewed
Traffic Lights with Auction-Based Controllers: Algorithms and Real-World Data (2017)

Real-time optimization of traffic flow addresses important practical problems: reducing a driver's wasted time, improving city-wide efficiency, reducing gas emissions and improving air quality. Much of the current research in traffic-light optimization relies on extending the capabilities of traffic lights to either communicate with each other or communicate with vehicles. However, before such capabilities become ubiquitous, opportunities exist to improve traffic lights by being more responsive to current traffic situations within the current, already deployed, infrastructure. In this paper, we introduce a traffic light controller that employs bidding within micro-auctions to efficiently incorporate traffic sensor information; no other outside sources of information are assumed. We train and test traffic light controllers on large-scale data collected from opted-in Android cell-phone users over a period of several months in Mountain View, California and the River North neighborhood of Chicago, Illinois. The learned auction-based controllers surpass (in both the relevant metrics of road-capacity and mean travel time) the currently deployed lights, optimized static-program lights, and longer-term planning approaches, in both cities, measured using real user driving data.
Internal standardization and calibration architectures for chemical sensors : 20-22 September 1999, Boston, Massachusetts (1999)

This work brings together a selection of papers dealing with various aspects of internal standardization and calibration architectures for chemical sensors.
Spectral Galerkin method for solving Helmholtz boundary integral equations on smooth screens (2021)

Abstract We solve first-kind Fredholm boundary integral equations arising from Helmholtz and Laplace problems on bounded, smooth screens in three dimensions with either Dirichlet or Neumann conditions. The proposed Galerkin–Bubnov methods take as discretization elements pushed-forward weighted azimuthal projections of standard spherical harmonics onto the unit disk. By exactly depicting edge singular behaviors we show that these spectral or high-order bases yield super-algebraic error convergence in the corresponding energy norms whenever the screen is an analytic deformation of the unit disk. Moreover, we provide a fully discrete analysis of the method, including quadrature rules, based on analytic extensions of the spectral basis to complex neighborhoods. Finally, we include numerical experiments to support our claims as well as appendices with computational details for treating the associated singular integrals.