gebhart/patrepeval huggingface dataset:
Innovative Offshore Wind Plant Design Study (2013)

Technological advancements in the Glosten PelaStar floating wind turbine system have led to projected cost of energy (COE) reductions from today’s best-in-class offshore wind systems. The PelaStar system is projected to deliver a COE that is 35% lower than that delivered by the current offshore wind plants. Several technology developments have been achieved that directly target significant cost of energy reductions. These include: Application of state-of-the-art steel construction materials and methods, including fatigue-resistant welding techniques and technologies, to reduce hull steel weight; Advancements in synthetic fiber tendon design for the mooring system, which are made possible by laboratory analysis of full-scale sub-rope specimens; Investigations into selected anchor technologies to improve anchor installation methods; Refinement of the installation method, specifically through development of the PelaStar Support Barge design. Together, these technology developments drive down the capital cost and operating cost of offshore wind plants and enable access to superb wind resources in deep water locations. These technology developments also reduce the uncertainty of the PelaStar system costs, which increases confidence in the projected COE reductions.
Supplementary Figure S6 from Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies (2023)

&lt;p&gt;Supplementary Figure S6. A. Bulk-rna-sequencing of neutrophils purified from whole blood 4 hrs and 20 hrs following treatment with 0.2 μg/mL CD20-TCB or 0.2 μg/mL DP47-TCB for N=4 donors. B. Heat map showing the enriched hallmark pathways in neutrophils, 4 hrs and 20 hrs following treatment with CD20-TCB or DP47-TCB. C. Heat map showing the expression of TNF-α (TNF), IL-1β (IL1B), IL-6 (IL6), MCP-1 (CCL2), MIP-1α (CCL3), MIP-1β (CCL4) and IP-10 (CXCL10) genes in neutrophils, 4 hrs and 20 hrs following treatment with CD20-TCB or DP47-TCB (untargeted TCB). Volcano plots depicting the cytokine genes in neutrophils D. 4 hrs and E. 20 hrs after treatment with CD20-TCB. Each dot represents one gene. The x axis shows the logarithmic fold change and the y axis shows the negative log of the p value for each gene by comparing samples treated with CD20-TCB to samples treated with DP47-TCB (untargeted TCB).&lt;/p&gt;
EARLY POSTOPERATIVE TRANSVERSE PELVIC FRACTURE (2005)

Background: Uncemented hemispherical cups are commonly used to revise failed acetabular total hip components, even in the presence of marked acetabular bone loss. The purpose of the present study was to report a new complication of acetabular component revision with an uncemented hemispherical cup. Methods: We retrospectively reviewed the records of seven patients (seven hips) in whom an early postoperative transverse acetabular fracture had developed following the implantation of an uncemented trabecular metal cup for the revision of a failed acetabular component. All patients were female. The average age was 63.6 years. The reason for acetabular revision was aseptic loosening of the original cup in five patients and reimplantation after a previous resection arthroplasty in the remaining two. The average cup size used for revision was 58 mm. In two hips, additional modular acetabular metal augments were used to restore the acetabular rim. Results: The average postoperative time to diagnosis of a transverse acetabular fracture was eight months. Five of the seven patients presented with a marked acute increase in pain and a new displaced transverse acetabular fracture (pelvic discontinuity) that was visible on plain radiographs. Two patients were asymptomatic but had a nondisplaced transverse acetabular fracture. In all seven patients, the trabecular metal socket appeared radiographically to be well fixed to part of the pelvis. The five patients with a displaced fracture were managed with additional surgery to stabilize the fracture. Conclusions: To our knowledge, early postoperative transverse pelvic fractures following revision of the acetabular component have not been reported previously. The most likely causes of this complication are further weakening of the remaining pelvic bone stock as a result of the reaming required to obtain a secure fit of a large-diameter hemispherical socket and the cyclic stresses on the weakened bone with resumption of walking. It is unlikely that the fractures occurred intraoperatively because in each case the socket remained well fixed to one of the pelvic fragments. Level of Evidence: Therapeutic Level IV. See Instructions to Authors for a complete description of levels of evidence.
See-through Brains and Diffusion Tensor MRI Clarified Fiber Connections: A Preliminary Microstructural Study in a Mouse with Callosal Agenesis (2015)

Clearing methods that render the brain optically transparent allow high-resolution three-dimensional (3D) imaging of neural networks. We used diffusion tensor imaging (DTI) and two-photon imaging of cleared brains to analyze white matter in BTBR mice. We confirmed corpus callosum agenesis and identified an abnormal commissure close to the third ventricle. DTI and cleared-brain two-photon imaging revealed that these commissural fibers constituted a frontal clustering of the ventral hippocampal commissure and provided a detailed assessment of white matter structure in mice.
Genetic Markers of Cisplatin-Induced Hearing Loss in Children (2014)

This journal recently published a Commentary by Ratain and colleagues at the University of Chicago that criticizes our work on cisplatin-induced hearing loss in children. It is unfortunate that neither the authors nor the editors of Clinical Pharmacology & Therapeutics corresponded with us to provide an earlier opportunity to address these questions. Here we correct the authors' inaccuracies and provide additional analyses that further strengthen our published findings.
Exploiting the message from cancer: the diagnostic value of extracellular vesicles for clinical applications (2019)

Liquid biopsy is indispensable for the resolution of current medical issues, such as the cost of developing new drugs and predicting responses of patients to drugs. In this sense, not only the technology for liquid biopsy but also the target biomolecules for biomarkers need to be identified. Extracellular vesicles (EVs), which contain various proteins, including membrane-bound proteins, and RNAs, including mRNA and long/short noncoding RNAs, have emerged as ideal targets for liquid biopsy. These complex biomolecules are covered by a lipid bilayer, which can protect them from degradation. In this review, we review current topics regarding EVs as cancer biomarkers and introduce technologies used for these recently emerged biomolecules.
The Impact of Coherence Diversity on MIMO Relays (2022)

This paper studies MIMO relays with non-identical link coherence times, a frequently occurring condition when, e.g., the nodes in the relay channel do not all have the same mobility, or the scatterers around some nodes have different mobility compared with those around other nodes. Despite its practical relevance, this condition, known as <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">coherence diversity</i> , has not been studied in the relay channel. This paper studies the performance of MIMO relays and proposes efficient transmission strategies under coherence diversity. Since coherence times have a prominent impact on channel training, we do not assume channel state is available to the decoder for free; all channel training resources are accounted for in the calculations. A product superposition technique is employed at the source which allows a more efficient usage of degrees of freedom when the relay and the destination have different training requirements. Varying configurations of coherence times are studied. The interesting case where the different link coherence intervals are not a multiple of each other, and therefore the coherence intervals do not align, is studied. Relay scheduling is combined with the product superposition to obtain further gains in degrees of freedom. The impact of coherence diversity is further studied in the presence of multiple parallel relays.
Spin-Selective AC Stark Shifts in a Charged Quantum Dot (2019)

We demonstrate a spin-selective modification to the energy structure of a charged quantum dot using the AC Stark effect. This mechanism offers a potentially rapid, reversible, and coherent control of the energy structure. © 2019 The Author(s)
Supplementary Fig. 5 from Clinical Importance of the lncRNA <i>NEAT1</i> in Cancer Patients Treated with Immune Checkpoint Inhibitors (2023)

&lt;p&gt;Supplementary Fig. 5 Classification of single cells.&lt;/p&gt;
A Semi-Active Control Method for Pneumatic Actuators with Evolutionary Algorithm (2019)

Pneumatic actuators have been investigated for assistive technologies such as exoskeletons. Compliant and energy efficient devices are desirable to use in daily activities. This paper introduces a novel control method to make an air cylinder function as a passive nonlinear spring with controllable stiffness. The controller computes the desired pressures based on a given stiffness. The air pressures in the cylinder are tuned accordingly, and the air cylinder starts to perform as a passive spring by closing the valves. Performance of the proposed method is validated through two experiments. The proposed method satisfies the desired stiffness response of less than 20 milliseconds and within ±5% of the desired pressures.
Synthesis of novel [3,2-b]indole fused oleanolic acids as potential inhibitors of cell proliferation (2003)

Seven new indole-fused oleanolic acid derivatives were synthesized from oleanolic acid for their ability to inhibit cell proliferation in NRP.152 cells.
A new sensing and digital-conversion scheme with adaptive image-quality adjustment for a fingerprint sensor chip (2002)

A new fingerprint sensing and digital-conversion scheme is proposed. In this scheme, transforming the sensed signal to a time axis widens the dynamic range of the signal, and the transformed signal is converted to the digital signal with variable range and offset. These features make it possible to sense various fingerprints clearly. We also propose a flow that adjusts the quality of the fingerprint image adaptively. The effectiveness of the scheme on sensing fingerprints clearly was confirmed by a test chip fabricated using 0.5-/spl mu/m CMOS/sensor process. This scheme assists in precise user identification for a safe and comfortable networked world.
Bicyclic Derivatives of the Potent Dual Aromatase–Steroid Sulfatase Inhibitor 2‐Bromo‐4‐{[(4‐cyanophenyl)(4H‐1,2,4‐triazol‐4‐yl)amino]methyl}phenylsulfamate: Synthesis, SAR, Crystal Structure, and in vitro and in vivo Activities (2010)

The design and synthesis of a series of bicyclic ring containing dual aromatase-sulfatase inhibitors (DASIs) based on the aromatase inhibitor (AI) 4-[(4-bromobenzyl)(4H-1,2,4-triazol-4-yl)amino]benzonitrile are reported. Biological evaluation with JEG-3 cells revealed structure-activity relationships. The X-ray crystal structure of sulfamate 23 was determined, and selected compounds were docked into the aromatase and steroid sulfatase (STS) crystal structures. In the sulfamate-containing series, compounds containing a naphthalene ring are both the most potent AI (39, IC(50 AROM)=0.25 nM) and the best STS inhibitor (31, IC(50 STS)=26 nM). The most promising DASI is 39 (IC(50 AROM)=0.25 nM, IC(50 STS)=205 nM), and this was evaluated orally in vivo at 10 mg kg(-1), showing potent inhibition of aromatase (93 %) and STS (93 %) after 3 h. Potent aromatase and STS inhibition can thus be achieved with a DASI containing a bicyclic ring system; development of such a DASI could provide an attractive new option for the treatment of hormone-dependent breast cancer.
Reducible Poly(amido ethylenimine)-Based Gene Delivery System for Improved Nucleus Trafficking of Plasmid DNA (2010)

In a nonviral gene delivery system, localization of a plasmid DNA in the nucleus is a prerequisite for expression of a desired therapeutic protein encoded in the plasmid DNA. In this study, a reducible polymer-based gene delivery system for improved intracellular trafficking and nuclear translocation of plasmid DNA is introduced. The system is consisted of two components, a plasmid DNA having repeated binding sequence for a karyophilic protein, NFkappaB, and a reducible polymer. A reducible poly(amido ethylenimine), poly(TETA-CBA), was synthesized by a Michael-type addition polymerization between cystamine bisacrylamide and triethyl tetramine. The polymer forming tight complexes with plasmid DNA could be degraded in the reductive cytosol to release the plasmid DNA. The triggered release mechanism in the cytosol could facilitate the interaction between cytosolic NFkappaB and the plasmid DNA having repeated NFkappaB biding motif. Upon activation of NFkappaB by interleukin-1beta (IL-1beta), most of the plasmid distributed in the cytoplasm was localized within the nucleus, resulting in significantly higher gene transfection efficiency than controls with nondegradable PEI. The current study suggests an alternative way of improving transfection efficiency by taking advantage of endogenous transport machinery for intracellular trafficking and nuclear translocation of a plasmid DNA.
Nanoparticles-enabled low temperature growth of carbon nanofibers and their properties for supercapacitors (2018)

Carbon nanostructures are of great interest for a variety of applications, but their current processing throughput limits their industrial full scale deployment. This paper presents a cost effective and simple fabrication process, where vertically aligned carbon nanofibers are grown using DC-PECVD at CMOS compatible temperatures from catalytic nanoparticles, spin-coated from stable polymer-nanoparticle colloidal suspensions. Two different catalysts, Co and Cu, are investigated by growing carbon nanofibers at temperatures ranging from 390°C to 550°C, using suspensions with various concentrations of nanoparticles. The length and morphology of the grown nanofibers are examined using SEM and the electrical properties are investigated using electrochemical measurements on samples arranged as supercapacitor devices. Vertically aligned CNFs are successfully grown from both types of catalyst. The Co-derived fibers are long and arranged in a denser carpet-like structure, while the Cu-derived fibers are shorter and in a sparser formation of free-standing individual fibers. All electrochemical measurements show typical supercapacitor behaviour even at high scan rates of 200 mVs -1 , with the fibers grown from Co showing great increase in capacitance over the bare chip reference device, including the samples grown at 390°C.
Propane/Propylene Diffusion in Zeolites: Framework Dynamics (2009)

Pure silica zeolites with narrow eight-membered (8-MR) oxygen rings are good candidates for separations of olefin/paraffin mixtures based on molecular sieving effects. We have used a molecular dynamics technique to study the structural features of two pure silica 8-MR frameworks: Si-CHA and Si-SAS. CHA and SAS are framework types with 3- and 1-dimensional porous systems, respectively, with cages connected through 8-MR windows. Window size temperature fluctuations were studied from equilibrium molecular dynamics simulations by allowing full flexibility of the framework. The thermal influence on diffusional features of propane/propylene molecules adsorbed in Si-CHA and Si-SAS zeolites is studied using classical molecular dynamics simulations. Potential energy surface effects are taken into account by comparing the results from the well-known van Beest, Kramer, and van Santen potential [Phys. Rev. Lett. 1990, 64, 1995] and the Pedone, Malavasi, Menziani, Cormack, and Segre potential [J. Phys. Chem. B 2006, 24, 11780].
Advances in Cryptology - CRYPTO '98: 18th Annual International Cryptology Conference, Santa Barbara, California, USA, August 23-27, 1998, Proceedings (1998)

Chosen ciphertext attacks against protocols based on the RSA encryption standard PKCS #1.- A practical public key cryptosystem provably secure against adaptive chosen ciphertext attack.- Relations among notions of security for public-key encryption schemes.- Cryptography and the internet.- Differential collisions in SHA-0.- From differential cryptanalysis to ciphertext-only attacks.- A simplified approach to threshold and proactive RSA.- New efficient and secure protocols for verifiable signature sharing and other applications.- Trading correctness for privacy in unconditional multi-party computation.- Fast digital identity revocation.- Self-delegation with controlled propagation - or - What if you lose your laptop.- Identity escrow.- Generalized birthday attacks on unbalanced Feistel networks.- Quadratic relation of S-box and its application to the linear attack of full round DES.- Cryptanalysis of block ciphers with probabilistic non-linear relations of low degree.- Cryptanalysis of the Ajtai-Dwork cryptosystem.- Cryptanalysis of the Chor-Rivest cryptosystem.- Cryptanalysis of the oil and vinegar signature scheme.- From unpredictability to indistinguishability: A simple construction of pseudo-random functions from MACs.- Many-to-one trapdoor functions and their relation to public-key cryptosystems.- Authentication, enhanced security and error correcting codes.- An efficient discrete log pseudo random generator.- Fast RSA-type cryptosystem modulo p k q.- An elliptic curve implementation of the finite field digital signature algorithm.- Quantum bit commitment from a physical assumption.- On concrete security treatment of signatures derived from identification.- Building PRFs from PRPs.- Security amplification by composition: The case of doubly-iterated, ideal ciphers.- On the existence of 3-round zero-knowledge protocols.- Zero-knowledge proofs for finite field arithmetic, or: Can zero-knowledge be for free?.- Concurrent zero-knowledge: Reducing the need for timing constraints.- The solution of McCurley's discrete log challenge.- Optimal extension fields for fast arithmetic in public-key algorithms.- Time-stamping with binary linking schemes.- Threshold traitor tracing.
Inside Cover: Polyoxometalates Made of Gold: The Polyoxoaurate [AuIII4AsV4O20]8− (Angew. Chem. Int. Ed. 10/2010) (2010)

A brand new line of gold jewelry has been designed in the world of polyoxometalate chemistry. In their Communication on page 1886 ff, U. Kortz et al. identify the first discrete inorganic polyoxoaurate [AuIII4AsV4O20]8− with a tetrameric structure and square-planar coordinated AuIII ions linked by oxo and arsenate bridging ligands (see structure; Au yellow, As blue, O red). The facile open-beaker synthetic procedure appears to be a convenient and general method for making a variety of gold-based inorganic oxo complexes. Mr. Rami Al-Oweini (PhD Student, Jacobs University) is thanked for his creative design.
Demonstration of Self-Aligned Flip-Chip Photonic Assembly with 1.1dB Loss and >120nm Bandwidth (2016)

We demonstrate direct flip-chip assembly of photonic dies with solder-induced self-alignment to sub-micron accuracy. We find a peak chip-to-chip transmission of -1.1 dB with 0.2 dB penalty over the 120 nm spectrum measured.
Human Cardiac Stem Cell Differentiation Is Regulated by a Mircrine Mechanism (2011)

The recognition that miR-499 promotes the differentiation of hCSCs into mechanically integrated cardiomyocytes has important clinical implications for the treatment of human heart failure.
The role of selected microelements: selenium, zinc, chromium and iron in immune system (2011)

The immune response is the process of recognition of potentially harmful agents by specialized cells of the immune system. It is expressed as cellular and humoral immunity. A number of nutrients have the ability to modulate immune response through the production of antibodies or cytokines (e.g. zinc, selenium, chromium). Moreover the elements are required for immune cells proliferation or activation (e.g. iron). The elements are also required for functioning of enzymes involved in antioxidant system (e.g. selenium) of the immune cells. It has been shown, that nutrient supplementation may enhance but may also suppress immune function.
Optimizing closed-loop adaptive-optics performance with use of multiple control bandwidths (1994)

The performance of a closed-loop adaptive-optics system may in principle be improved by selection of distinct and independently optimized control bandwidths for separate components, or modes, of the wave-front-distortion profile. We describe a method for synthesizing and optimizing a multiple-bandwidth adaptive-optics control system from performance estimates previously derived for single-bandwidth control systems operating over a range of bandwidths. The approach is applicable to adaptive-optics systems that use either one or several wave-front sensing beacons and also to systems that include multiple deformable mirrors for atmospheric-turbulence compensation across an extended field of view. Numerical results are presented for the case of an atmospheric-turbulence profile consisting of a single translating phase screen with Kolmogorov statistics, a Shack–Hartmann wave-front sensor with from 8 to 16 subapertures across the aperture of the telescope, and a continuous-face-sheet deformable mirror with actuators conjugate to the corners of the wave-front-sensor subapertures. The use of multiple control bandwidths significantly relaxes the wave-front-sensor noise level that is permitted for the adaptive-optics system to operate near the performance limit imposed by fitting error. Nearly all of this reduction is already achieved through the use of a control system that uses only two distinct bandwidths, one of which is the zero bandwidth.
Participation of Decreased Serum CholesteryI Ester Transfer Activity, Independent of Increased Serum Lipoprotein(a), in Angina Pectoris in Normolipemic Elderly Subjects (1992)

The cholesteryl ester transfer activity (CETA) is a measurement of the transfer of cholesteryl ester from HDL to VLDL, LDL or peripheral cells. Its role in the development of early coronary heart disease is not clear. In the present study, serum levels of CETA, lipoprotein(a) [Lp(a)] and other lipid-related factors were compared in 10 normal young subjects, 28 healthy elderly subjects and 14 normolipemic elderly patients with angina pectoris. Compared to the young normals and healthy elderly subjects, the elderly patients with angina pectoris showed significantly decreased mean serum CETA levels, and significantly increased mean serum levels of Lp(a) and apoprotein B. These results may indicate that decreased serum values of CETA participate in the development of angina pectoris in normolipemic elderly patients.