gebhart/patrepeval huggingface dataset:
Modulation of keratinocyte growth factor receptor expression in human cultured keratinocytes. (1997)

Keratinocyte growth factor (KGF) belongs to the fibroblast growth factor (FGF) family, and its activity seems to be restricted to epithelial cells. It elicits its biological effects through binding to the KGF receptor (KGFR), a splicing transcript variant of FGF receptor 2 (FGFR2). The presence of multiple isoforms of FGFR2 and the overlapping specificities of the FGFs with respect to their receptors do not allow the use of anti-FGFR antibodies as specific immunocytochemical tools. Here we used a chimeric protein recently obtained by the fusion of KGF to the HFc portion of immunoglobulin G (La Rochelle et al., J. Cell Biol., 129: 357-366, 1995) to analyze the expression and distribution of KGFRs in human keratinocytes cultured in chemically defined medium and incubated with different Ca2+ concentrations to modulate their differentiation. We observed at both immunofluorescence and electron microscopic levels and by Western blot analysis of proliferation (K6) or differentiation (K1) markers that KGFR expression is up-modulated during keratinocyte differentiation. Cytofluorimetric and Western blot analysis revealed that exposure to the high Ca2+ differentiation signal resulted in a significant increase in KGFRs. RNase protection assay using a KGFR-specific cDNA probe demonstrated that this effect was correlated with a > 4-fold increase in KGFR transcript level. Our results suggest that the expression of KGFR, unlike that of the epidermal growth factor receptor, may control the proliferative-differentiative program from basal to suprabasal cells in human skin.
Search for a pentaquark decaying to pKS0 (2006)

We present a search for a pentaquark decaying strongly to pKS0 in γN collisions at a center-of-mass energy up to 25 GeV. Finding no evidence for such a state in the mass range of 1470MeV/c2 to 2200MeV/c2, we set limits on the yield and on the cross section times branching ratio relative to Σ∗(1385)± and K∗(892)+.
Orthogonality of Separation in Two-Dimensional Liquid Chromatography (2005)

Two-dimensional liquid chromatography is often used to reduce the proteomic sample complexity prior to tandem mass spectrometry analysis. The 2D-LC performance depends on the peak capacity in both chromatographic dimensions, and separation orthogonality. The peak capacity and selectivity of many LC modes for peptides is not well known, and mathematical characterization for orthogonality is underdeveloped. Consequently, it is difficult to estimate the performance of 2D-LC for peptide separation. The goal of this paper was to investigate a selectivity of common LC modes and to identify the 2D-LC systems with a useful orthogonality. A geometric approach for orthogonality description was developed and applied for estimation of a practical peak 2D-LC capacity. Selected LC modes including various RP, SCX, SEC, and HILIC were combined in 2D-LC setups. SCX-RP, HILIC-RP, and RP-RP 2D systems were found to provide suitable orthogonality. The RP-RP system (employing significantly different pH in both RP separation dimensions) had the highest practical peak capacity of 2D-LC systems investigated.
Therapy in nephrology and hypertension : a companion to Brenner and Rector's The kidney (2003)

Part A. Clinical Trials--General Principles. Principles of Epidemiology and Their Applications to Nephrology. Design and Interpretation of Clinical Trials in Nephrology and Hypertension. A Clinician's Guide to Meta-Analysis in Nephrology. Part B. Acute Renal Failure (ARF). Prerenal ARF. Ischemic Acute Tubular Necrosis. Nephrotoxic Acute Renal Failure. Contrast Nephrology. Hepatorenal Syndrome. Acute Hemodialysis and Acute Peritoneal Dialysis. Slow Continuous Blood Purification for Treatment of ARF. Nutritional Management of Acute Renal Failure. Experimental Strategies for ARF. The Future. Part C. Diseases of Glomeruli, Microvasculature and Tubulo Interstitium. Renal Biopsy as a Guide to the Treatment of Glomerulonephritis. Immunosuppressive Therapy in Immunologic Renal Disease and Transplantation. Dietary Modulation of the Inflammatory Response. Plasmapheresis and Renal Disease. Management of Infection-Associated Glomerulonephritis Cryoglobulinemia. Lupus Nephritis. Iga Nephropathy and Henoch Schonlein Purpura. Crescentic Glomerulonephritis. Anti-GBM Antibody Disease. Treatment of ANCA-Associated Small Vessel Vasculitis. Minimal Change Disease. Primary Focal Segmental Glomerulonephritis. Glomerular Deposition Diseases. Therapy of HIV-Associated Renal Diseases. Management of Complications of Nephrotic Syndrome. Thrombotic Microangiopathies. Treatment of Allergic Interstitial Nephritis. New Horizons in Treatment of Renal Inflammation. Part D. Diabetic Nephropathy. Prevention and Management of Diabetic Nephropathy. The Diabetic Patient with ESRD. Part E. Disorders of Fluid, Electrolyte and Acid-Base Homeostasis. Therapy of Dysnatremia Disorders. Treatment of Hypokalemia and Hyperkalemia. Metabolic Acidosis. Metabolic Alkalosis. Respiratory and Mixed Acid Base Disorders. Disorders of Calcium, Phosphate and Magnesium. Homeostasis. Part F. Nephrolithiasis. Medical Management of Nephrolithiasis. The Role of Lithotripsy in the Treatment of Nephrolithiasis. Surgical Management of Renal Calculi. Part G. Genito-Urinar
Graphene Field Effect Transistors with Mica as Gate Dielectric Layers (2014)

Chemical vapor deposited monolayer graphene is transferred onto atomically flat and ultra-thin muscovite mica to study the transport characteristics of graphene with a test structure of mica-based graphene field effect transistor (GFET). The transfer curve of the 24 nm mica-based GFET shows an effective carrier mobility of 2748 cm(2)/Vs and a transconductance of 3.36 μS, a factor of 2 and 7 larger than those values obtained from 40 nm SiO2 based GFET, respectively. The results demonstrate that mica is an excellent gate dielectric material due to its high dielectric constant, high dielectric strength, and atomically flat surface.
Infection of dendritic cells with herpes simplex virus type 1 induces rapid degradation of CYTIP, thereby modulating adhesion and migration (2011)

Immune responses require spatial and temporal coordinated interactions between different cell types within distinct microenvironments. This dynamic interplay depends on the competency of the involved cells, predominantly leukocytes, to actively migrate to defined sites of cellular encounters in various tissues. Because of their unique capacity to transport antigen from the periphery to secondary lymphoid tissues for the activation of naive T cells, dendritic cells (DCs) play a key role in the initiation and orchestration of adaptive immune responses. Therefore, pathogen-mediated interference with this process is a very effective way of immune evasion. CYTIP (cytohesin-interacting protein) is a key regulator of DC motility. It has previously been described to control LFA-1 deactivation and to regulate DC adherence. CYTIP expression is up-regulated during DC maturation, enabling their transition from the sessile to the motile state. Here, we demonstrate that on infection of human monocyte-derived DCs with herpes simplex virus type 1 (HSV-1), CYTIP is rapidly degraded and as a consequence β-2 integrins, predominantly LFA-1, are activated. Furthermore, we show that the impairment of migration in HSV-1-infected DCs is in part the result of this increased integrin-mediated adhesion. Thus, we propose a new mechanism of pathogen-interference with central aspects of leukocyte biology.
(Keynote) Engineering Interfaces for Electrochemical Devices Using Atomic Layer Deposition (2022)

Meeting the world’s growing energy needs sustainably is one of the most important challenges of our time, and electrochemical devices such as fuel cells and batteries will continue to hold a significant place in sustainable energy systems. Due to the central role that interfaces have in electrochemical systems, it is critical to engineer and control these interfaces. This talk will describe our research on layer-by-layer synthetic strategies, namely atomic layer deposition (ALD), to engineer thin film materials used at electrochemical interfaces with a high level of control over composition, structure, and thickness. Both battery and electrocatalysis applications for energy storage and conversion will be described. We use ALD interfacial layers deposited on the copper current collector as a new strategy to control lithium metal morphology and improve electrochemical performance in Li metal batteries. Specifically, TiO 2 films deposited by ALD on the current collector of lithium anodes generate a lithiophilic surface layer that enables uniform and reversible Li plating, leading in turn to improvements in battery cyclability. Other metal oxide interfacial layers are also shown to influence lithium morphology and battery performance. Toward electrocatalysis, we show that nanometer thick layers of earth abundant materials deposited by ALD are active for the oxygen evolution reaction (OER), an important reaction in the conversion of sunlight to fuels. Nickel-oxide, nickel-iron-oxide, and nickel-aluminum-oxide films are synthesized with controlled composition by ALD and the promotion of the OER activity by iron and aluminum is explored. The potential of atomic layer deposition to synthesize nanoscale materials and engineer interfaces for electrochemical energy applications will be discussed.
Scalability analysis in terms of crosstalk in NZ-DSF ring networks constructed with WSS based ROADM (2007)

In optical ring networks, the impact of residual fiber dispersion on the cascadability limit of the optical add-drop systems due to in-band crosstalk is investigated. An experimentally verified re-circulating non-zero dispersion shifted fiber (NZ-DSF) loop model is used to emulate the cascade effect of multiple add-drop nodes. The nodes are implemented based on Wavelength Selective Switches (WSSs) at varying node degrees to support different network configurations. It is shown that 16 node metro rings can be constructed cost effectively using NZ-DSF, at link distances of 75 km, for fiber dispersions as high as 4.6 and 1.2 ps/nm-km at bit rates of 2.5 and 10 Gb/s, respectively, at a 1dB of crosstalk induced penalty. A modular architecture extending to large degree ROADM for mesh networks is also proposed and scalability in terms of crosstalk is reported.
An image intensifier based high resolution X-ray imaging system for mammography (2002)

The authors present the design specs of a digital X-ray imaging system for mammography. The imaging system is based on the concept of microfluoroscopy in which the maximum image intensifier spatial resolution is matched to the TV camera's resolution by a zoom lens optically coupled to the output phosphor of the detector. The system uses an image intensifier with a beryllium window for soft X-ray detection. Furthermore, the system also employs a unique dual anode X-ray tube that will have tungsten/molybdenum for target material. The authors' results obtained by simulation show that by combining the higher detection efficiency of a mammographic image intensifier with the improved X-ray production capability of the W-anode tube, in conjunction with the sensitivity and linearity of current CCD and digital technology, one should be able to reduce the dose to the breast, retain high spatial resolution over a large field of view while simultaneously shortening the exposure time. The X-ray mammography system presented in the current work should be able to detect smaller structures with improved spatial resolution due to the shorter exposure times to be used while also reducing the dose to the patient.
Boiling Study of Nanofluid on Graphene Coated Substrate (2013)

A comparative study is done to understand the effect of variation in surface energy of substrates on boiling and
dry-out characteristics of nanofluid. Droplet of TiO2 nanofluid on glass substrate shows strong pinning along
the droplet perimeter. As the droplet evaporates, boundary of nanofluid droplet recedes slowly towards the
center leaving a ring-shaped stain of concentrated nanoparticles. Surface energy of glass substrate is modified
by graphene coating, confirmed by increase in contact angle. While boiling of nanofluid on graphene coated
glass substrate shows an almost uniform dry-out pattern. Reduced wettability of nanofluid droplet on graphene
coated glass substrate is responsible for this behavior.
Polymorphisms in the promoter region of macrophage migration inhibitory factor and monocyte chemoattractant protein-1 are associated with increased risk for gastric cancer in a Chinese population (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4606 

Gastric cancer is the 2nd leading cause of cancer deaths in the world. Inflammatory cytokine gene polymorphisms are shown to influence the risk of gastric cancer. The cytokine macrophage migration inhibitory factor (MIF) is a constitutive element of the host antimicrobial defenses and promotes proinflammatory function of the innate and acquired immune systems. Monocyte chemoattractant protein-1 (MCP-1) is a beta-chemokine involved in the attraction and accumulation of mononuclear granulocytes toward sites of inflammation. Promoter polymorphisms in MIF (-173 G/C) and MCP-1 (-2518 A/G) affect the level of MIF and MCP-1 expression. These polymorphisms are shown to be associated with increased susceptibility to or severity of chronic inflammatory conditions such as rheumatoid arthritis, ulcerative colitis, or HCV-related liver diseases, but their association with inflammation-associated cancers such as gastric cancer is not studied. To investigate whether these polymorphisms are associated with altered risk for gastric cancer, we carried out a hospital-based case control study. Cases included 206 patients with histologically confirmed non-cardia gastric cancer diagnosed at the teaching hospitals of Sun Yat-Sen University in Guangzhou and Xi’an Medical University in Xi’an. 206 healthy individuals visiting the teaching hospitals for regular physical examinations were recruited as controls. Controls were frequency-matched to cases by gender, age (± 5 years), and the hospital. All study subjects were ethnical Han Chinese. The MIF -173 and MCP-1 -2518 polymorphisms were genotyped by PCR and sequencing of the PCR product. The mean age for cases were 60.2 years (± 11.7) and 58.2 (± 10.7) years for controls. Genotype frequencies of the MIF -173 and MCP-1 -2518 polymorphisms among healthy controls were in Hardy-Weinberg equilibrium. Compared to subjects with a GG genotype at the MIF -173 position, subjects with a GC genotype had an increased risk for gastric cancer after adjusting for age, gender, and H. Pylori infection status (OR: 1.92; 95% CI: 0.99-3.75) and subjects with a homologous CC genotype had a significantly higher risk for gastric cancer (OR: 3.01; 95% CI: 1.52-5.89). Compared to subjects with a CC genotype at the MCP-1 -2518 position, carriers with a G allele were at higher risk for gastric cancer, with an OR of 1.57 (95% CI: 1.01-2.44) for CG genotype and 1.84 (95% CI: 1.05-3.23) for GG genotype. In a combined analysis, subjects homologous for both loci (CC at MIF -173 and GG at MCP-1 -2518) had significantly increased risk for gastric cancer (OR: 8.31; 95% CI: 1.67-41.21). In conclusion, our results suggest that polymorphisms in the promoter region of MIF (G->C at -173) and MCP-1 (C->G at -2518) are associated with increased risk for gastric cancer in the Chinese population.
Development and evaluation of a connective tissue phantom model for subsurface visualization of cancers requiring wide local excision (2017)

Wide local excision (WLE) of tumors with negative margins remains a challenge because surgeons cannot directly visualize the mass. Fluorescence-guided surgery (FGS) may improve surgical accuracy; however, conventional methods with direct surface tumor visualization are not immediately applicable, and properties of tissues surrounding the cancer must be considered. We developed a phantom model for sarcoma resection with the near-infrared fluorophore IRDye 800CW and used it to iteratively define the properties of connective tissues that typically surround sarcoma tumors. We then tested the ability of a blinded surgeon to resect fluorescent tumor-simulating inclusions with ∼1-cm margins using predetermined target fluorescence intensities and a Solaris open-air fluorescence imaging system. In connective tissue-simulating phantoms, fluorescence intensity decreased with increasing blood concentration and increased with increasing intralipid concentrations. Fluorescent inclusions could be resolved at ≥1-cm depth in all inclusion concentrations and sizes tested. When inclusion depth was held constant, fluorescence intensity decreased with decreasing volume. Using targeted fluorescence intensities, a blinded surgeon was able to successfully excise inclusions with ∼1-cm margins from fat- and muscle-simulating phantoms with inclusion-to-background contrast ratios as low as 2∶1. Indirect, subsurface FGS is a promising tool for surgical resection of cancers requiring WLE.
ChemInform Abstract: Asymmetric Epoxidation of a Geminally‐Disubstituted and Some Trisubstituted Enones Catalyzed by Poly‐L‐leucine. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Methods and Materials, Figures 1-5 from AXL Is a Potential Target for Therapeutic Intervention in Breast Cancer Progression (2023)

Supplementary Methods and Materials, Figures 1-5 from AXL Is a Potential Target for Therapeutic Intervention in Breast Cancer Progression
Fundamentals of Digital Communication (2008)

This is a concise presentation of the concepts underlying the design of digital communication systems, without the detail that can overwhelm students. Many examples, from the basic to the cutting-edge, show how the theory is used in the design of modern systems and the relevance of this theory will motivate students. The theory is supported by practical algorithms so that the student can perform computations and simulations. Leading edge topics in coding and wireless communication make this an ideal text for students taking just one course on the subject. Fundamentals of Digital Communications has coverage of turbo and LDPC codes in sufficient detail and clarity to enable hands-on implementation and performance evaluation, as well as 'just enough' information theory to enable computation of performance benchmarks to compare them against. Other unique features include space-time communication and geometric insights into noncoherent communication and equalization.
RE: SOMATOSENSORY EVOKED POTENTIALS IN PATIENTS WITH PRIMARY PREMATURE EJACULATION (1998)

No AccessJournal of UrologyClinical Urology: Letters to the Editor1 Jun 1998RE: SOMATOSENSORY EVOKED POTENTIALS IN PATIENTS WITH PRIMARY PREMATURE EJACULATION Z.C. Xin, Y.D. Choi, K.H. Rha, and H.K. Choi Z.C. XinZ.C. Xin More articles by this author , Y.D. ChoiY.D. Choi More articles by this author , K.H. RhaK.H. Rha More articles by this author , and H.K. ChoiH.K. Choi More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)63281-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "RE: SOMATOSENSORY EVOKED POTENTIALS IN PATIENTS WITH PRIMARY PREMATURE EJACULATION." The Journal of Urology, 159(6), p. 2104 References 1 : The neuroanatomical basis for the protopathic sensibility of the human glans penis. Brain Res.1986; 371: 205. Google Scholar 2 : Penile sensitivity in patients with primary premature ejaculation. J. Urol.1996; 156: 979. Link, Google Scholar 3 : Somatosensory evoked potential in patients with primary premature ejaculation. J. Urol.1997; 158: 451. Abstract, Google Scholar 4 : Sensory evoked potential and effect of SS-cream in premature ejaculation. Yonsei Med. J.1995; 36: 397. Google Scholar 5 : Diseases of the peripheral nerves. In: Greenfield's Neuropathology. London: Edward Arnold1992: 1147. Google Scholar 6 : Efficacy of a topical agent SS-cream in the treatment of premature ejaculation: preliminary clinical studies. Yonsei Med. J.1997; 38: 91. Google Scholar 7 : A newly developing topical agent (SS-cream) for premature ejaculation: preliminary clinical studies. Int. J. Impotence Res.1996; 8: A53. Google Scholar © 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 159Issue 6June 1998Page: 2104 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information Z.C. Xin More articles by this author Y.D. Choi More articles by this author K.H. Rha More articles by this author H.K. Choi More articles by this author Expand All Advertisement PDF DownloadLoading ...
Organic Cage Dumbbells (2020)

Molecular dumbbells with organic cage capping units were synthesised via a multi-component imine condensation between a tri-topic amine and di- and tetra-topic aldehydes. This is an example of self-sorting, which can be rationalised by computational modelling.
Neural Paraphrase Identification of Questions with Noisy Pretraining (2017)

We present a solution to the problem of paraphrase identification of questions. We focus on a recent dataset of question pairs annotated with binary paraphrase labels and show that a variant of the decomposable attention model (Parikh et al., 2016) results in accurate performance on this task, while being far simpler than many competing neural architectures. Furthermore, when the model is pretrained on a noisy dataset of automatically collected question paraphrases, it obtains the best reported performance on the dataset.
Decrease in Angiotensin-Converting Enzyme activity but not concentration in plasma/lungs in COVID-19 patients offers clues for diagnosis/treatment (2022)

Although several therapeutics are used to treat coronavirus disease 2019 (COVID-19) patients, there is still no definitive metabolic marker to evaluate disease severity and recovery or a quantitative test to end quarantine. Because severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects human cells via the angiotensin-converting-enzyme 2 (ACE2) receptor and COVID-19 is associated with renin-angiotensin system dysregulation, we evaluated soluble ACE2 (sACE2) activity in the plasma/saliva of 80 hospitalized COVID-19 patients and 27 non-COVID-19 volunteers, and levels of ACE2/Ang (1-7) in plasma or membrane (mACE2) in lung autopsy samples. sACE2 activity was markedly reduced (p < 0.0001) in COVID-19 plasma (n = 59) compared with controls (n = 27). Nadir sACE2 activity in early hospitalization was restored during disease recovery, irrespective of patient age, demographic variations, or comorbidity; in convalescent plasma-administered patients (n = 45), restoration was statistically higher than matched controls (n = 22, p = 0.0021). ACE2 activity was also substantially reduced in the saliva of COVID-19 patients compared with controls (p = 0.0065). There is a strong inverse correlation between sACE2 concentration and sACE2 activity and Ang (1-7) levels in participant plasmas. However, there were no difference in membrane ACE2 levels in lungs of autopsy tissues of COVID-19 (n = 800) versus other conditions (n = 300). These clinical observations suggest sACE2 activity as a potential biomarker and therapeutic target for COVID-19.