gebhart/patrepeval huggingface dataset:
Bortezomib for Steroid Refractory Acute Graft Versus Host Disease (GVHD) (2012)

Steroid refractory GVHD remains a significant problem after allogeneic HSCT with a mortality rate exceeding 90% in some series and no standard for salvage treatment. Murine data suggest bortezomib inhibits acute GVHD, but preserves graft-versus-tumor effect. We sought to test whether the same activity could be demonstrated in a clinical setting. Patients were eligible for the trial if they had clinical or histological evidence of acute GVHD and had been treated with 2mg/kg/day of methylprednisolone and had 1) either a minimum of 3 days of corticosteroids with progressive disease or 2) a minimum of 7 days without a response or 3) had progression when steroids were tapered to less than 2mg/kg/day of methylprednisolone. Bortezomib was given at a dose of 1.3mg/m2 administered as a bolus intravenous injection twice weekly for 2 weeks (days 1, 4, 8, 11) followed by a 10 day rest period constituting one 21 day treatment cycle. A complete response (CR) was defined as no clinical or laboratory signs of acute GVHD in all organs, and a partial response (PR) required at least a 1 grade reduction in overall GVHD scoring in at least 1 organ system without worsening in others. Response was determined on day 21 after the first cycle and every 3 weeks until 3 months after the last cycle or death whichever came first. After the 1st cycle, patients achieving CR or PR were treated with additional cycles until they had a dose limiting toxicity or a complete response, and patients without response were taken off study and considered treatment failure. Three of 11 patients treated were not evaluable for efficacy; 1 withdrew from the study after less than 1 cycle without signs of toxicity, 1 died 1 week after receiving the 1st cycle of septic shock, and the 3rd patient developed a concomitant viral infection that could not be distinguished from possible concomitant GVHD. Of the 8 evaluable patients 4 had no response and 4 had at least a partial response. In the 4 patients with responses 2 were complete responses and 2 were partial. Ten of the 11 patients have died, 2 of progressive disease, 6 of infection, 1 of hemorrhage and 1 of pulmonary toxicity. Whether bortezomib contributed to any of these deaths was unclear. One of the partial responders was taken off the study for peripheral neuropathy and is still alive 4.5 years later. In this small study bortezomib demonstrated some activity in steroid refractory acute GVHD with some neurotoxicity.
Femto-second laser fabrication of phase change material nanostructures for novel applications (2011)

In this paper, we will demonstrate our recent results of laser lithography of nanostructures of phase change material for novel nanophotonic application.
Interkingdom Responses to Bacterial Quorum Sensing Signals Regulate Frequency and Rate of Nodulation in Legume–Rhizobia Symbiosis (2016)

Density-dependent phenotypic switching in bacteria, the phenomenon of quorum sensing (QS), is instrumental in many pathogenic and mutualistic behaviors. In many Gram-negative bacteria, QS is regulated by N-acylated-l-homoserine lactones (AHLs). Synthetic analogues of these AHLs hold significant promise for regulating QS at the host-symbiont interface. Regulation depends on refined temporal and spatial models of quorums under native conditions. Critical to this is an understanding of how the presence of these signals may affect a prospective host. We screened a library of AHL analogues for their ability to regulate the legume-rhizobia mutualistic symbiosis (nodulation) between Medicago truncatula and Sinorhizobium meliloti. Using an established QS-reporter line of S. meliloti and nodulation assays with wild-type bacteria, we identified compounds capable of increasing either the rate of nodule formation or total nodule number. Most importantly, we identified compounds with activity exclusive to either host or pathogen, underscoring the potential to generate QS modulators selective to bacteria with limited effects on a prospective host.
Liquid Crystal Alignment on the SiC Thin Film by the Ion Beam Exposure Method (2005)

We studied the nematic liquid crystal (NLC) aligning capabilities using the new alignment material of the SiC (Silicon Carbide) thin film. The SiC thin film exhibits good chemical and thermal stability. The good thermal and chemical stability makes SiC an attractive candidate for electronic applications. A vertical alignment of nematic liquid crystal by ion beam exposure on the SiC thin film surface was achieved. The about <TEX>$87{\circ}$</TEX> of stable pretilt angle was achieved at the range from <TEX>$30{\circ}$</TEX> to <TEX>$45{\circ}$</TEX> of incident angle. The good LC alignment is maintained by the ion beam alignment method on the SiC thin film surface at high annealing temperatures up to <TEX>$300{\circ}C$</TEX>.
An exploration of disinfection by-products formation and governing factors in chlorinated swimming pool water (2018)

This paper investigates disinfection by-products (DBPs) formation and their relationship with governing factors in chlorinated swimming pools. The study compares concentrations of DBPs with WHO guidelines for drinking water quality recommended to screen swimming pool water quality. The statistical analysis is based on a global database of 188 swimming pools accumulated from 42 peer-reviewed journal publications from 16 countries. The mean and standard deviation of dichloroacetic acid and trichloroacetic acid were estimated as 282 ± 437 and 326 ± 517 μg L<sup>-1</sup>, respectively, which most often surpassed the WHO guidelines. Similarly, more than half of the examined pools had higher values of chloral hydrate (102 ± 128 μg L<sup>-1</sup>). The concentration of total chloramines (650 ± 490 μg L<sup>-1</sup>) was well above the WHO guidelines in all reported cases. Nevertheless, the reported values remained below the guidelines for most of the studied pools in the case of total trihalomethanes (134 ± 160 μg L<sup>-1</sup>), dichloroacetonitrile (12 ± 12 μg L<sup>-1</sup>) and dibromoacetonitrile (8 ± 11 μg L<sup>-1</sup>). Total organic carbon, free residual chlorine, temperature, pH, total nitrogen and bromide ions play a pivotal role in DBPs formation processes. Therefore, proper management of these governing factors could significantly reduce DBPs formation, thereby, contributing towards a healthy swimming pool environment.
A Novel Formulation of Elastic Interaction in Gasketed Bolted Joints (2007)

A novel mathematical model is proposed for studying elastic interaction in gasketed bolted joints. The model predicts the tension changes in tightened bolts due to the subsequent tightening of other bolts in the joint. It also predicts the final clamp load distribution after the completion of joint tightening. The model is used to investigate the effect of various factors on the elastic interaction phenomenon; factors include the gasket thickness, bolt spacing, fastener preload level, and the tightening sequence of various bolts. Experimental verification is provided for the validation of the mathematical model. Experimental and analytical results are presented and discussed. The proposed model provides good prediction of the final clamp load in the joint. Moreover, the proposed model may be used to determine the level of initial bolt tension in each bolt that would be necessary to achieve the desired level of uniform clamp load in the joint at initial assembly.
Reduced coagulation at high altitude identified by thromboelastography (2012)

The impact of hypoxaemia on blood coagulation remains unclear despite use of a variety of measures to address the issue. We report the first use of thromboelastography (TEG) at high altitude to describe the dynamics of clot formation in whole blood samples. Seventeen healthy volunteers ascended to 5,300 m following an identical ascent profile; TEG measurements at 4,250 m and 5,300 m were compared with those from sea level. Peripheral oxygen saturation (SpO2) and haematocrit were also measured. Ascent resulted in a decline in SpO2 from 97.8 (± 1.2) % at sea level to 86.9 (± 3.3) % at 4,250 m and 79.5 (± 5.8) % at 5,300 m (p<0.001); haematocrit rose from 43.7 (± 2.8) % at sea level, to 46.7 (± 3.9) % and 52.6 (± 3.2) % at 4,250 m and 5,300 m, respectively (p<0.01). TEG reaction (R)-time and kinetic (K)-time were both increased at 5,300 m compared to sea level, 8.95 (± 1.37) minutes (min) to 11.69 (± 2.91) min (p=0.016) and 2.40 (± 0.66) min to 4.99 (± 1.67) min (p<0.001), respectively. Additionally the alpha (α)-angle was decreased from 57.7 (± 8.2) to 51.6 (± 6.4) (p<0.001). There was no change in maximum amplitude (MA) on ascent to altitude. These changes are consistent with an overall pattern of slowed coagulation at high altitude.
The future of electrical I/O for microprocessors (2009)

High-speed CMOS microprocessor I/O has scaled aggressively over the past decade in terms of power and performance largely due to advances in equalization and clocking techniques. With future multi-core processors expected to require >1TB/s bandwidth and dramatically improved power efficiency, there has been some question as to whether electrical I/O will continue to satisfy chip-to-chip communication requirements over the next decade. In this paper, we show that electrical signaling has the power, performance, and density scaling potential to enable the next several generations of systems and applications. Circuit innovation is aggressively pushing link power efficiency toward 1-2mW/Gb/s while departures from legacy channels to include new topologies and materials can significantly improve the power/performance/density tradeoff. Statistical link-level design tools that allow designers to rapidly quantify high-level architecture tradeoffs will enable balanced link designs that co-optimize power, performance, and channel topology.
Comparing implementations of magnetic-resonance-guided fluorescence molecular tomography for diagnostic classification of brain tumors (2010)

Fluorescence molecular tomography (FMT) systems coupled to conventional imaging modalities such as magnetic resonance imaging (MRI) and computed tomography provide unique opportunities to combine data sets and improve image quality and content. Yet, the ideal approach to combine these complementary data is still not obvious. This preclinical study compares several methods for incorporating MRI spatial prior information into FMT imaging algorithms in the context of in vivo tissue diagnosis. Populations of mice inoculated with brain tumors that expressed either high or low levels of epidermal growth factor receptor (EGFR) were imaged using an EGF-bound near-infrared dye and a spectrometer-based MRI-FMT scanner. All data were spectrally unmixed to extract the dye fluorescence from the tissue autofluorescence. Methods to combine the two data sets were compared using student's t-tests and receiver operating characteristic analysis. Bulk fluorescence measurements that made up the optical imaging data set were also considered in the comparison. While most techniques were able to distinguish EGFR(+) tumors from EGFR(-) tumors and control animals, with area-under-the-curve values=1, only a handful were able to distinguish EGFR(-) tumors from controls. Bulk fluorescence spectroscopy techniques performed as well as most imaging techniques, suggesting that complex imaging algorithms may be unnecessary to diagnose EGFR status in these tissue volumes.
Scaling Experiments On A Magnetically Insulated Thermionic Vacuum Switch (2005)

Magnetic insulation of the electron flow in a cylindrical thermionic vacuum diode has been proposed as a way to achieve a fast high-voltage high-power opening switch. The expected performance of this type of device can be derived from a set of basic scaling laws combined with empirical relationships obtained from experimental studies. Switch losses are mainly due to anode dissipation W{sub a}, which can be normalized to the transferred pulse energy. Leakage current and switch hold-off voltage depend on device geometry, materials, vacuum conditions etc and must be determined experimentally. For this purpose, the MX-1 experiment has been designed and operated. This device is basically a smooth-bore cylindrical magnetron with a 5 cm radius, 400 cm{sup 2} area thermionic dispenser cathode separated from the coaxial water-cooled anode by a few mm wide gap. This design allows pulsed operation at up to {approximately}100 kV, {approximately}4 kA and average power levels of {approximately}1 MW. The MX-1 switch is used as an opening switch to produce 1--2 {mu}s long square pulses from an inductive storage PFN. The current-voltage characteristics of the switch are determined as a function of the applied magnetic field and load condition. Plasma wave measurements are performed to investigate themore » stability of the electron flow. Results are summarized in the form of scaling diagrams for the important switch parameters, showing possible performance levels and physical and technical limitations identified as far in this work.« less
Efficacy of a novel, protein-based pneumococcal vaccine against nasopharyngeal carriage of Streptococcus pneumoniae in infants: A phase 2, randomized, controlled, observer-blind study (2017)

PATH, GlaxoSmithKline Biologicals SA. ClinicalTrials.gov identifier NCT01262872.
Semi-autonomous simulated brain tumor ablation with RAVENII Surgical Robot using behavior tree (2015)

Medical robots have been widely used to assist surgeons to carry out dexterous surgical tasks via various ways. Most of the tasks require surgeon's operation directly or indirectly. Certain level of autonomy in robotic surgery could not only free the surgeon from some tedious repetitive tasks, but also utilize the advantages of robot: high dexterity and accuracy. This paper presents a semi-autonomous neurosurgical procedure of brain tumor ablation using RAVEN Surgical Robot and stereo visual feedback. By integrating with the behavior tree framework, the whole surgical task is modeled flexibly and intelligently as nodes and leaves of a behavior tree. This paper provides three contributions mainly: (1) describing the brain tumor ablation as an ideal candidate for autonomous robotic surgery, (2) modeling and implementing the semi-autonomous surgical task using behavior tree framework, and (3) designing an experimental simulated ablation task for feasibility study and robot performance analysis.
Single-seed oxygen consumption measurements and population-based threshold models link respiration and germination rates under diverse conditions (2016)

Abstract Seed germination is responsive to diverse environmental, hormonal and chemical signals. Germination rates (i.e. speed and distribution in time) reveal information about timing, uniformity and extent of germination in seed populations and are sensitive indicators of seed vigour and stress tolerance. Population-based threshold (PBT) models have been applied to describe germination responses to temperature, water potential, hormones, ageing and oxygen. However, obtaining detailed data on germination rates of seed populations requires repeated observations at frequent times to construct germination time courses, which is labour intensive and often impractical. Recently, instruments have been developed to measure repeatedly the respiration (oxygen consumption) of individual seeds following imbibition, providing complete respiratory time courses for populations of individual seeds in an automated manner. In this study, we demonstrate a new approach that enables the use of single-seed respiratory data, rather than germination data, to characterize the responses of seed populations to diverse conditions. We applied PBT models to single-seed respiratory data and compared the results to similar analyses of germination time courses. We found consistent and quantitatively comparable relationships between seed respiratory and germination patterns in response to temperature, water potential, abscisic acid, gibberellin, respiratory inhibitors, ageing and priming. This close correspondence between seed respiration and germination time courses enables the use of semi-automated respiratory measurements to assess seed vigour and quality parameters. It also raises intriguing questions about the fundamental relationship between the respiratory capacities of seeds and the rates at which they proceed toward completion of germination.
Superadiabatic theory for Cooper pair pumping under decoherence (2011)

We introduce a method where successive coordinate transformations are applied to decrease the error in the adiabatic master equation resulting from truncation in the local adiabatic parameter. Our method reduces the nonphysical behavior stemming from the lack of complete positivity. The strong environment-induced relaxation at high Cooper pair pumping frequencies leads to adiabatic ground-state pumping only in the lowest-order approximation. We illustrate the robustness of the frequency where the adiabaticity breaks down using the high-order theory and show the emergence of an optimal environmental coupling strength, for which ideal pumping is preserved for the highest frequency. Finally, we study the effect of quantum interference on the pumped current and give an estimate for the relaxation rate of an experimentally measured system.
In situ Synthesis of Ag2S Nanosized Particles in Porous Materials Using Single-source Precursor (2005)

Abstract Ag2S nanoparticles were synthesized in situ by thermal decomposition of a single-source precursor (SSP, silver diethyldithiocarbamate) in the pores of porous Vycor glass (PVG). The precursor was incorporated into PVG by sublimation or impregnation of a solution of the precursor. The band gaps of Ag2S in PVGs were estimated to be 1.63 and 1.43 eV for the samples prepared by the decomposition of the precursor incorporated by these two methods, indicating occurrence of quantum size effect in the nanoparticles.
<title>All-solid-state continuous-wave 266-nm laser for optical disk mastering</title> (1998)

All-solid-state cw 266 nm laser operates greater than 1000 hours with diffraction-limited beam and low noise output (-130 dB/Hz), which is suitable for next-generation disk mastering.© (1998) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Instant restore after a media failure (2017)

Media failures usually leave database systems unavailable for several hours until recovery is complete, especially in applications with large devices and high transaction volume. Previous work introduced a technique called single-pass restore, which increases restore bandwidth and thus substantially decreases time to repair. Instant restore goes further as it permits read/write access to any data on a device undergoing restore--even data not yet restored--by restoring individual data segments on demand. Thus, the restore process is guided primarily by the needs of applications, and the observed mean time to repair is effectively reduced from several hours to a few seconds. This paper presents an implementation and evaluation of instant restore. The technique is incrementally implemented on a system starting with the traditional ARIES design for logging and recovery. Experiments show that the transaction latency perceived after a media failure can be cut down to less than a second and that the overhead imposed by the technique on normal processing is minimal. The net effect is that a few "nines" of availability are added to the system using simple and low-overhead software techniques.
Increased expression of the blood group‐related Lewis Y antigen on synovial fluid granulocytes of patients with arthritic joint diseases (2001)

The selective increase in LeY antigen on SF granulocytes in RA, SA and OA suggests a role of the LeY oligosaccharide in granulocyte traffic and inflammatory responses.
Human Rhinovirus 2A Proteinase Cleavage Sites in Eukaryotic Initiation Factors (eIF) 4GI and eIF4GII Are Different (2003)

Several picornaviruses shut down host cellular protein synthesis by proteolytic cleavage of the eukaryotic initiation factor (eIF) 4GI and eIF4GII isoforms. Viral RNA translation is maintained by a cap-independent mechanism. Here, we identify the human rhinovirus 2 2A(pro) cleavage site in eIF4GII in vitro as PLLNV(699)*GSR; this sequence lies seven amino acids C-terminal to the cleavage site previously identified in eIF4GI (LSTR681*GPP).
Triosephosphate isomerase catalysis is diffusion controlled. Appendix: Analysis of triose phosphate equilibria in aqueous solution by phosphorus-31 NMR (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTriosephosphate isomerase catalysis is diffusion controlled. Appendix: Analysis of triose phosphate equilibria in aqueous solution by phosphorus-31 NMRWendell A. Lim, Ronald T. Raines, and Jeremy R. KnowlesCite this: Biochemistry 1988, 27, 4, 1165–1167Publication Date (Print):February 23, 1988Publication History Published online1 May 2002Published inissue 23 February 1988https://pubs.acs.org/doi/10.1021/bi00404a014https://doi.org/10.1021/bi00404a014research-articleACS PublicationsRequest reuse permissionsArticle Views86Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Effect of Visual Information on Young Children’s Perceptual Sensitivity to Musical Beat Alignment (2015)

Recent work examined five-year-old children’s perceptual sensitivity to musical beat alignment. In this work, children watched pairs of videos of puppets drumming to music with simple or complex metre, where one puppet’s drumming sounds (and movements) were synchronized with the beat of the music and the other drummed with incorrect tempo or phase. The videos were used to maintain children’s interest in the task. Five-year-olds were better able to detect beat misalignments in simple than complex metre music. However, adults can perform poorly when attempting to detect misalignment of sound and movement in audiovisual tasks, so it is possible that the moving stimuli actually hindered children’s performance. Here we compared children’s sensitivity to beat misalignment in conditions with dynamic visual movement versus still (static) visual images. Eighty-four five-year-old children performed either the same task as described above or a task that employed identical auditory stimuli accompanied by a motionless picture of the puppet with the drum. There was a significant main effect of metre type, replicating the finding that five-year-olds are better able to detect beat misalignment in simple metre music. There was no main effect of visual condition. These results suggest that, given identical auditory information, children’s ability to judge beat misalignment in this task is not affected by the presence or absence of dynamic visual stimuli. We conclude that at five years of age, children can tell if drumming is aligned to the musical beat when the music has simple metric structure.