gebhart/patrepeval huggingface dataset:
Streaming from the Air: Enabling High Data-rate 5G Cellular Links for Drone Streaming Applications. (2021)

Enabling high data-rate uplink cellular connectivity for drones is a challenging problem, since a flying drone has a higher likelihood of having line-of-sight propagation to base stations that terrestrial UEs normally do not have line-of-sight to. This may result in uplink inter-cell interference and uplink performance degradation for the neighboring ground UEs when drones transmit at high data-rates (e.g., video streaming). We address this problem from a cellular operator's standpoint to support drone-sourced video streaming of a point of interest. We propose a low-complexity, closed-loop control system for Open-RAN architectures that jointly optimizes the drone's location in space and its transmission directionality to support video streaming and minimize its uplink interference impact on the network. We prototype and experimentally evaluate the proposed control system on an outdoor multi-cell RAN testbed. Furthermore, we perform a large-scale simulation assessment of the proposed system on the actual cell deployment topologies and cell load profiles of a major US cellular carrier. The proposed Open-RAN-based control achieves an average 19% network capacity gain over traditional BS-constrained control solutions and satisfies the application data-rate requirements of the drone (e.g., to stream an HD video).
High activity of an affinity-matured ACE2 decoy against Omicron SARS-CoV-2 and pre-emergent coronaviruses (2022)

The viral genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), particularly its cell-binding spike protein gene, has undergone rapid evolution during the coronavirus disease 2019 (COVID-19) pandemic. Variants including Omicron BA.1 and Omicron BA.2 now seriously threaten the efficacy of therapeutic monoclonal antibodies and vaccines that target the spike protein. Viral evolution over a much longer timescale has generated a wide range of genetically distinct sarbecoviruses in animal populations, including the pandemic viruses SARS-CoV-2 and SARS-CoV-1. The genetic diversity and widespread zoonotic potential of this group complicates current attempts to develop drugs in preparation for the next sarbecovirus pandemic. Receptor-based decoy inhibitors can target a wide range of viral strains with a common receptor and may have intrinsic resistance to escape mutant generation and antigenic drift. We previously generated an affinity-matured decoy inhibitor based on the receptor target of the SARS-CoV-2 spike protein, angiotensin-converting enzyme 2 (ACE2), and deployed it in a recombinant adeno-associated virus vector (rAAV) for intranasal delivery and passive prophylaxis against COVID-19. Here, we demonstrate the exceptional binding and neutralizing potency of this ACE2 decoy against SARS-CoV-2 variants including Omicron BA.1 and Omicron BA.2. Tight decoy binding tracks with human ACE2 binding of viral spike receptor-binding domains across diverse clades of coronaviruses. Furthermore, in a coronavirus that cannot bind human ACE2, a variant that acquired human ACE2 binding was bound by the decoy with nanomolar affinity. Considering these results, we discuss a strategy of decoy-based treatment and passive protection to mitigate the ongoing COVID-19 pandemic and future airway virus threats.
Total Synthesis of 16-Desmethylepothilone B, Epothilone B10, Epothilone F, and Related Side Chain Modified Epothilone B Analogues (2000)

The macrolactonization-based strategy for the total synthesis of epothilones has been streamlined and improved to a high level of efficiency and stereoselectivity. This strategy has been applied to the construction of vinyl iodide 19 which served as a common intermediate for the synthesis of a series of natural and designed epothilones including an epothilone B10 (3), epothilone F (5), 16-desmethylepothilone B (14), pyridine epothilones 57a-57g, dimeric epothilones 59 and 61, and benzenoid epothilones 63a-63g.
Synthesis of bis(trifluoromethylated) pyrazine-containing nitrogen heterocycles from hexafluorobiacetyl and ortho-diamines. Stabilization of the covalent dihydrates of pteridines and pyrido[3,4-b]pyrazines by trifluoromethyl groups (1986)

An investigation of the structures of the reaction products derived from perfluorobutane-2,3-dione (PFBD) and a variety of ortho-diamines has been undertaken with the aim of determining the extent to which trifluoromethyl groups stabilize covalently bound hydrates. The substituted quinoxalines as well as the pyrido[2,3-b]pyrazine (25) and the lumazines (27), (29), and (31) were all found to exist as completely dehydrated aromatic species. Depending on the reaction conditions, both the aromatic form (33) and the stable, neutral covalent dihydrate form (34) could be obtained from the reaction of PFBD with 4,5-diamino-6-hydroxypyrimidinium sulphate (32). The pyrido[3,4-b]pyrazine system (36) as well as the pteridine (38) were also found to exist as stable, neutral covalent dihydrates in which the pyrazine ring is selectively hydrated.
Diabetic kidney disease: act now or pay later. (2010)

The 21st century has the most diabetogenic environment in human history with the number of people with diabetes worldwide increasing to 380 million by 2025. The fastest rate of increase will be in developing countries. Diabetes is now the major cause of end-stage kidney disease globally; 20%-40% of people on dialysis are diabetic. In Australia, the number of people with type 2 diabetes starting dialysis increased fivefold between 1993 and 2007. We must act now at local, national and international levels to prevent type 2 diabetes; screen for early diabetic kidney disease; increase public awareness of kidney disease; treat with medications proven to reduce kidney disease progression; and promote research into and trialling of new therapies. The problem is global yet requires local action. World Kidney Day on 11 March 2010 is a time to intensify action on diabetic kidney disease and to continue to do so until this huge but largely preventable health burden is controlled.
Rational synthesis of gold-ceria catalysts supported on reduced graphene oxide with remarkable activity for CO oxidation (2023)

Abstract Gold (Au)- and ceria (CeO 2 )-based catalysts are amongst the most active catalysts for the gas phase CO oxidation reaction. Nevertheless, nanosized Au and CeO 2 catalysts may encounter heat-induced sintering in thermochemical catalytic reactions. Herein, we report on the rational one-pot synthesis of ceria-reduced graphene oxide (CeO 2 -RGO) using a facile ethylenediamine (EDA)-assisted solvothermal method. Standalone RGO and free-standing CeO 2 were also prepared using the same EDA-assisted method for comparison. We then incorporated Au into the prepared samples by colloidal reduction and evaluated the catalytic activity of the different catalysts for CO oxidation. The RGO-supported CeO 2 surpassed the free-standing CeO 2 , exhibiting a 100% CO conversion at 285 o C compared to 340 o C in the case of CeO 2 . Interestingly, the RGO-supported Au/CeO 2 catalysts outperformed the Au/CeO 2 catalysts and achieved a 100% CO conversion at 76 o C compared to 113 o C in the case of Au/CeO 2 . Additionally, the Au/CeO 2 -RGO catalyst demonstrated remarkable room-temperature activity with simultaneous 72% CO conversion. This outstanding performance was attributed to the unique dispersion and size characteristics of the RGO-supported CeO 2 and Au catalysts in the ternary Au/CeO 2 -RGO nanocomposite, as revealed by TEM and XPS, among other techniques.
Electrostatic control of DNA intersegmental translocation by the ETS transcription factor ETV6 (2017)

To find their DNA target sites in complex solution environments containing excess heterogeneous DNA, sequence-specific DNA-binding proteins execute various translocation mechanisms known collectively as facilitated diffusion. For proteins harboring a single DNA contact surface, long-range translocation occurs by jumping between widely spaced DNA segments. We have configured biosensor-based surface plasmon resonance to directly measure the affinity and kinetics of this intersegmental jumping by the ETS-family transcription factor ETS variant 6 (ETV6). To isolate intersegmental target binding in a functionally defined manner, we pre-equilibrated ETV6 with excess salmon sperm DNA, a heterogeneous polymer, before exposing the nonspecifically bound protein to immobilized oligomeric DNA harboring a high-affinity ETV6 site. In this way, the mechanism of ETV6-target association could be toggled electrostatically through varying NaCl concentration in the bulk solution. Direct measurements of association and dissociation kinetics of the site-specific complex indicated that 1) freely diffusive binding by ETV6 proceeds through a nonspecific-like intermediate, 2) intersegmental jumping is rate-limited by dissociation from the nonspecific polymer, and 3) dissociation of the specific complex is independent of the history of complex formation. These results show that target searches by proteins with an ETS domain, such as ETV6, whose single DNA-binding domain cannot contact both source and destination sites simultaneously, are nonetheless strongly modulated by intersegmental jumping in heterogeneous site environments. Our findings establish biosensors as a general technique for directly and specifically measuring target site search by DNA-binding proteins via intersegmental translocation.
Charles Baxter: un festín literario en los suburbios (2003)

The essential oil of Plectranthus rugosus (Labiatae) was investigated by GLC, NMR and mass spectrometry. Main constituents are caryophyllene, germacrene D, alpha-phellandrene, alpha-pinene, caryophyllene oxide, alpha-cadinol, delta-cadinene, limonene, beta-phellandrene, myrcene, and p-cymene.
Optimization of Application-Specific Memories (2013)

Memory access times are the primary bottleneck for many applications today. This “memory wall” is due to the performance disparity between processor cores and main memory. To address the performance gap, we propose the use of custom memory subsystems tailored to the application rather than attempting to optimize the application for a fixed memory subsystem. Custom subsystems can take advantage of application-specific properties as well as memory-specific properties to improve access times or write-backs given constraints on size or power.
The Physiology of the Grid (2003)

This chapter contains sections titled: Introduction The Need for Grid Technologies Background An Open Grid Services Architecture Application Example Technical Details Network Protocol Bindings Higher-level Services Related Work Summary Acknowledgments References
Exploiting Octahedral Stereocenters: From Enzyme Inhibition to Asymmetric Photoredox Catalysis (2017)

A simple concept, namely exploiting the structural and stereochemical complexity of octahedral metal complexes, can have unexpected impact in different areas of chemical research, from medicinal chemistry and chemical biology to asymmetric catalysis and photoredox chemistry.
Novel germline p16INK4 allele (Asp145Cys) in a family with multiple pancreatic carcinomas (1998)

As part of a search for causative genes of familial pancreatic carcinoma, the p16 genes were sequenced in members of 21 families with a phenotype of familial pancreatic carcinoma (2 or more first degree relatives affected). One family was found in which affected members carried a novel p16 allele with a G to T transversion at position 451, creating a missense amino acid change at codon 145 (Asp to Cys) and possibly disrupting the donor splice site of the exon 2/3 boundary. This coding change is not a known polymorphism, and occurs at a codon position in which another missense/splicing change has been shown to be linked to familial melanoma/pancreas cancer. Hum Mutat 12:70, 1998. © 1998 Wiley-Liss, Inc.
Using strong sustainability to optimize electricity generation fuel mixes (2008)

This work represents a contribution to the field of sustainable electricity system design by using an optimization tool to specify the final mix composition, subject to the constraints of: emissions that are within the biocapacity of the region; a diverse and robust electricity supply system; and supply that at least meets current demand. The 25-country European Union (EU-25) is used as a case study. All the goals, save diversity, can be met by re-structuring the current fuel mix, thus maintaining current consumption levels. The diversity target is only met when consumption is reduced by 10-15% and the constraint on maximum material throughput is relaxed. Re-structuring the mix and reducing consumption is insufficient to achieve a sustainable EU carbon footprint. However, the solution proposed singlehandedly allows the EU to meet its Kyoto emissions target as well as its 2007 policy of a reduction of 20% in greenhouse gas emissions by 2020.
Type I IFN Signaling Is Crucial for Host Resistance against Different Species of Pathogenic Bacteria (2007)

It is known that host cells can produce type I IFNs (IFN-alphabeta) after exposure to conserved bacterial products, but the functional consequences of such responses on the outcome of bacterial infections are incompletely understood. We show in this study that IFN-alphabeta signaling is crucial for host defenses against different bacteria, including group B streptococci (GBS), pneumococci, and Escherichia coli. In response to GBS challenge, most mice lacking either the IFN-alphabetaR or IFN-beta died from unrestrained bacteremia, whereas all wild-type controls survived. The effect of IFN-alphabetaR deficiency was marked, with mortality surpassing that seen in IFN-gammaR-deficient mice. Animals lacking both IFN-alphabetaR and IFN-gammaR displayed additive lethality, suggesting that the two IFN types have complementary and nonredundant roles in host defenses. Increased production of IFN-alphabeta was detected in macrophages after exposure to GBS. Moreover, in the absence of IFN-alphabeta signaling, a marked reduction in macrophage production of IFN-gamma, NO, and TNF-alpha was observed after stimulation with live bacteria or with purified LPS. Collectively, our data document a novel, fundamental function of IFN-alphabeta in boosting macrophage responses and host resistance against bacterial pathogens. These data may be useful to devise alternative strategies to treat bacterial infections.
An Alternative Host Material for Long‐Lifespan Blue Organic Light‐Emitting Diodes Using Thermally Activated Delayed Fluorescence (2017)

It has been challenging to find stable blue organic light emitting diodes (OLEDs) that rely on thermally activated delayed fluorescence (TADF). Lack of stable host materials well‐fitted to the TADF emitters is one of the critical reasons. The most popular host for blue TADF, bis[2‐(diphenylphosphino)phenyl] ether oxide (DPEPO), leads to unrealistically high maximum external quantum efficiency. DPEPO is however an unstable material and has a poor charge transporting ability, which in turn induces an intrinsic short OLED operating lifespan. Here, an alternative host material is introduced which educes the potential efficiency and device lifespan of given TADF emitters with the appropriateness of replacing the most popular host material, DPEPO, in developing blue TADF emitters. It simultaneously provides much longer device lifespan and higher external quantum efficiency at a practical brightness due to its high material stability and electron‐transport‐type character well‐fitted for hole‐transport‐type TADF emitters.
On controlling light transport in poor visibility environments (2008)

Poor visibility conditions due to murky water, bad weather, dust and smoke severely impede the performance of vision systems.Passive methods have been used to restore scene contrast under moderate visibility by digital postprocessing.However, these methods are ineffective when the quality of acquired images is poor to begin with.In this work, we design active lighting and sensing systems for controlling light transport before image formation, and hence obtain higher quality data.First, we present a technique of polarized light striping based on combining polarization imaging and structured light striping.We show that this technique out-performs different existing illumination and sensing methodologies.Second, we present a numerical approach for computing the optimal relative sensor-source position, which results in the best quality image.Our analysis accounts for the limits imposed by sensor noise.
Leveraging γ‐Glutamyl Transferase To Direct Cytotoxicity of Copper Dithiocarbamates against Prostate Cancer Cells (2018)

A prodrug approach is presented to direct copper-dependent cytotoxicity to prostate cancer cells. The prochelator GGTDTC requires activation by γ-glutamyl transferase (GGT) to release the metal chelator diethyldithiocarbamate from a linker that masks its thiol reactivity and metal binding properties. In vitro studies demonstrated successful masking of copper binding as well as clean liberation of the chelator by GGT. GGTDTC was stable to non-specific degradation when incubated with a series of prostate cancer and normal cell lines, with selective release of diethyldithiocarbamate only occurring in cells with measurable GGT activity. The antiproliferative efficacy of the prochelator correlated with cellular GGT activity, with 24 h inhibitory concentrations ranging from 800 nm in prostate cancer lines 22Rv1 and LNCaP to over 15 μm in normal prostate PWR-1E cells. These findings underscore a new strategy to leverage the amplified copper metabolism of prostate cancer by conditional activation of a metal-binding pharmacophore.
Towards more active biocatalysts in organic media: Increasing the activity of salt‐activated enzymes (2001)

The activation of freeze-dried subtilisin Carlsberg (SC) in hexane has been systematically studied and partially optimized with respect to the freezing method, the addition of inorganic salts and lyoprotectants, the initial concentration and final weight percent of additives, and the amount of water added to the organic solvent. Activity and water content were found to correlate directly with the kosmotropicity of the activating salt (kosmotropic salts bind water molecules strongly relative to the strength of water-water interactions in bulk solution). Combinations of kosmotropic salts with known lyoprotectants such as poly(ethylene glycol) (PEG) and sugars did not yield an appreciably more active catalyst. However, the combination of the kosmotropic sodium acetate with the strongly buffering sodium carbonate activated the enzyme more than the individual additives alone. Enzyme activity was enhanced further by the addition of small amounts of water to the organic solvent. Under optimal conditions, enzyme activity in hexane was improved over 27,000-fold relative to the salt-free enzyme, reaching a catalytic efficiency that was within one order of magnitude of k(cat)/K(m) for hydrolysis of the same substrate in aqueous buffer. Further activation to attain even higher catalytic efficiencies may be possible with additional optimization.
Selective Kv1.5 Blockers: Development of (R)-1-(Methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a Potential Treatment for Atrial Arrhythmia (2009)

Atrial fibrillation is the most prevalent form of cardiac arrhythmia. Current treatments extend the atrial effective refractory period by nonselective blockade of cardiac ion channels. An alternative approach selectively targeting the Kv1.5 ion channel offers the opportunity for therapeutic benefit with decreased risk of adverse cardiovascular events. KVI-020 (4g) successfully demonstrated antiarrhythmic efficacy in a canine arrhythmia model, and these findings support its utility as an antiarrhythmic agent.
A survey of software learnability (2009)

It is well-accepted that learnability is an important aspect of usability, yet there is little agreement as to how learnability should be defined, measured, and evaluated. In this paper, we present a survey of the previous definitions, metrics, and evaluation methodologies which have been used for software learnability. Our survey of evaluation methodologies leads us to a new question-suggestion protocol, which, in a user study, was shown to expose a significantly higher number of learnability issues in comparison to a more traditional think-aloud protocol. Based on the issues identified in our study, we present a classification system of learnability issues, and demonstrate how these categories can lead to guidelines for addressing the associated challenges.
Dynamic Modeling Of Tractor-semitrailer Vehicles In Automated Highway Systems (1995)

This report is concerned with the dynamic modeling of the tractor- semitrailer vehicles in Automated Highway Systems (AHS). The objectives of the research are to characterize the dynamic response of articulated heavy-duty vehicles, identify the key system parameters, develop control algorithms to achieve automatic guidance, and conduct experiments on lateral guidance control of articulated heavy-duty vehicles. A modeling approach for roll, pitch and yaw motions of tractor-semitrailer vehicles is described.
Overview of the TREC 2022 deep learning track (2025)

This is the fourth year of the TREC Deep Learning track. As in previous years, we leverage the MS MARCO datasets that made hundreds of thousands of human annotated training labels available for both passage and document ranking tasks. In addition, this year we also leverage both the refreshed passage and document collections that were released last year leading to a nearly $16$ times increase in the size of the passage collection and nearly four times increase in the document collection size. Unlike previous years, in 2022 we mainly focused on constructing a more complete test collection for the passage retrieval task, which has been the primary focus of the track. The document ranking task was kept as a secondary task, where document-level labels were inferred from the passage-level labels. Our analysis shows that similar to previous years, deep neural ranking models that employ large scale pretraining continued to outperform traditional retrieval methods. Due to the focusing our judging resources on passage judging, we are more confident in the quality of this year's queries and judgments, with respect to our ability to distinguish between runs and reuse the dataset in future. We also see some surprises in overall outcomes. Some top-performing runs did not do dense retrieval. Runs that did single-stage dense retrieval were not as competitive this year as they were last year.
Metal-replacement studies in Bacillus stearothermophilus aldolase and a comparison of the mechanisms of class I and class II aldolases (1976)

A comparison of the product-inhibition patterns during cleavage of D-fructose 1,6-diphosphate by aldolases from yeast, rabbit muscle and Bacillus stearothermophilus shows an ordered reaction sequence for all three enzymes, with dihydroxyacetone phosphate the last-leaving product. Addition of Zn2+, Co2+, Fe2+, Mn2+ or Cd2+ ions to the inactive apo-(Bacillus stearothermophilus aldolase) restores activity to different extents, whereas Ni2+, Mg2+ or Cu2+ ions have no effect. The cleavage activity of this aldolase is not enhanced by added K+ ion. The effects of metal replacement on thermal stability, Km and Vmax. are given and the possible role of the metal is discussed in the light of these results.
Draft Genome Sequence of Tomitella biformata AHU 1821 T , Isolated from a Permafrost Ice Wedge in Alaska (2014)

Tomitella biformata AHU 1821(T) was isolated and cultured from a permafrost ice wedge, aged presumably about 25,000 years, in the Fox permafrost tunnel (64.952°N 147.617°W), Alaska. These genome data provide the basis for investigating T. biformata AHU 1821(T), identified as a long-term survivor of the extremely cold and closed environment.