gebhart/patrepeval huggingface dataset:
Collaborative Trust: A Novel Paradigm of Trusted Mobile Computing (2010)

With increasing complexity of modern-day mobile devices, security of these devices in presence of myriad attacks by an intelligent adversary is becoming a major issue. The vast majority of cell phones still remain unsecured from many existing and emerging security threats. To address the security threats in mobile devices we are exploring a technology, which we refer as "Collaborative Trust". It is a technology that uses a system of devices cooperating with each other (working in a fixed or ad-hoc network) to achieve the individual security of each device. The idea is that each device is insecure by itself, since in many cases it is incapable of checking its safety by itself (e.g. when it is compromised it may lose its ability to monitor its own trustworthiness), but together, they can ensure each other's security in a collaborative manner.
Exceptional transmission of plastids and mitochondria from the transplastomic pollen parent and its impact on transgene containment (2007)

Plastids in Nicotiana tabacum are normally transmitted to the progeny by the maternal parent only. However, low-frequency paternal plastid transmission has been reported in crosses involving parents with an alien cytoplasm. Our objective was to determine whether paternal plastids are transmitted in crosses between parents with the normal cytoplasm. The transplastomic father lines carried a spectinomycin resistance (aadA) transgene incorporated in the plastid genome. The mother lines in the crosses were either (i) alloplasmic, with the Nicotiana undulata cytoplasm that confers cytoplasmic male sterility (CMS92) or (ii) normal, with the fertile N. tabacum cytoplasm. Here we report that plastids from the transplastomic father were transmitted in both cases at low (10(-4)-10(-5)) frequencies; therefore, rare paternal pollen transmission is not simply due to breakdown of normal controls caused by the alien cytoplasm. Furthermore, we have found that the entire plastid genome was transmitted by pollen rather than small plastid genome (ptDNA) fragments. Interestingly, the plants, which inherited paternal plastids, also carried paternal mitochondrial DNA, indicating cotransmission of plastids and mitochondria in the same pollen. The detection of rare paternal plastid transmission described here was facilitated by direct selection for the transplastomic spectinomycin resistance marker in tissue culture; therefore, recovery of rare paternal plastids in the germline is less likely to occur under field conditions.
Design for a robot to assist laparoscopic surgeries with optimized motion both inside and outside the abdominal cavity of a patient (2018)

Laparoscopic surgery, which is also called as a minimally invasive surgery, is a surgical technique that is associated with an accelerated post-operative recovery. However, it can only be performed by surgeons possessing advanced surgical skills. One of the main challenges in laparoscopic surgery is the restriction of the free motion of forceps because of the limited degrees of freedom imposed by a trocar. Recently, to overcome this problem, many master–slave manipulators with articulated forceps have been used in laparoscopic surgery. However, these conventional manipulators are only intended for surgical procedures within the abdominal cavity. A robot that can be used for both laparoscopic surgeries and procedures outside the patient's abdominal cavity would be widely implemented. Therefore, during the design of a robot to assist with laparoscopic surgeries, it is important to optimize its motion both inside and outside the abdominal cavity. In this study, we propose a seven-axis redundant vertical articulated manipulator with a liner axis at its distal end. The working area of the proposed manipulator was compared with that of a six-axis vertical articulated manipulator within a patient's abdominal cavity to demonstrate the effectiveness of the redundant manipulator in increasing the working area.
8 Tbps Co-Packaged FPGA and Silicon Photonics Optical IO (2021)

The first 8 Tbps co-packaged FPGA with Silicon-Photonics IO is presented paving the way for co-packaged compute and optical-IO. The Multi-Chip Package integrates Stratix® 10 FPGA with up to five optical IO chiplets.
Colloidal Polymers with Controlled Sequence and Branching Constructed from Magnetic Field Assembled Nanoparticles (2015)

The assembly of nanoparticles into polymer-like architectures is challenging and usually requires highly defined colloidal building blocks. Here, we show that the broad size-distribution of a simple dispersion of magnetic nanocolloids can be exploited to obtain various polymer-like architectures. The particles are assembled under an external magnetic field and permanently linked by thermal sintering. The remarkable variety of polymer-analogue architectures that arises from this simple process ranges from statistical and block copolymer-like sequencing to branched chains and networks. This library of architectures can be realized by controlling the sequencing of the particles and the junction points via a size-dependent self-assembly of the single building blocks.
Sátira e ironia na poesia de Manuel António Pina (2013)

Neste artigo procuramos identificar e caracterizar o trabalho de (des)construção paródica de Manuel António Pina, em cuja poesia confluem vozes e memórias (do quotidiano, da literatura, da música, do cinema…) que suscitam comentários de tipo irónico e satírico. Mas esta ironia e esta sátira, mais ou menos humorísticas, nunca são meramente destrutivas e unívocas; propõem sempre reflexões que convidam a olhar o mundo de maneira menos convencional e previsível.
Camera Imaging Lens Fabrication using Wafer-Scale UV Embossing Process (2006)

We have developed a compact and cost-effective camera module on the basis of wafer-scale-replica processing. A multiple-layered structure of several aspheric lenses in a mobile-phone camera module is first assembled by bonding multiple glass-wafers on which 2-dimensional replica arrays of identical aspheric lenses are UV-embossed, followed by dicing the stacked wafers and packaging them with image sensor chips. This wafer-scale processing leads to at least 95% yield in mass-production, and potentially to a very slim phone with camera-module less than 2 mm in thickness. We have demonstrated a VGA camera module fabricated by the wafer-scale-replica processing with various UV-curable polymers having refractive indices between 1.4 and 1.6, and with three different glass-wafers of which both surfaces are embossed as aspheric lenses having <TEX>$230{\mu}m$</TEX> sag-height and aspheric-coefficients of lens polynomials up to tenth-order. We have found that precise compensation in material shrinkage of the polymer materials is one of the most technical challenges, in orderto achieve a higher resolution in wafer-scaled lenses for mobile-phone camera modules.
Quantification of Sternal Morphology Across Ages and Genders Using Image Segmentation and Registration Techniques (2012)

Thoracic injury ranks second only to head injury in motor vehicle crash injuries in terms of the number of fatalities and serious injuries, the body region most often injured, and the overall economic cost [1, 2]. Skeletal and physiological resilience are known to decline with age, resulting in a decreased ability for the body to withstand traumatic insults [3]. Adults 65 years of age and older constitute more than 12% of the current population and with increases in life expectancy, the elderly population is projected to reach nearly 20% by 2030 [4].
Tunneling current spectroscopy of electron subbands in n-type δ-doped silicon structures grown by molecular beam epitaxy (1990)

Tunneling current measurements on n-type δ-doped Si(100) structures were carried out, with sheet doping concentrations ranging from ∼4×1012 to 2.0×1013 cm−2 at 4 K. All samples have been grown by using a low-energy ion source for antimony doping in a silicon molecular beam epitaxy system. From analysis of dI/dVg and (dI/dVg)/ (I/Vg) spectra, tunneling associated with quantized electron subbands is identified. The subband energy positions relative to the equilibrium Fermi level EF0 under zero bias were determined from the tunneling current measurements as a function of the sheet doping concentration. Self-consistent theoretical calculations of the electronic structure of δ layers have been performed, and good agreement between theory and experiment is obtained for most structures in the tunneling spectra.
A study of the phase transitions in cyclic poly(dimethylsiloxane) by Raman spectroscopy and thermal analysis (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA study of the phase transitions in cyclic poly(dimethylsiloxane) by Raman spectroscopy and thermal analysisStephen J. Clarson and John F. RaboltCite this: Macromolecules 1993, 26, 10, 2621–2623Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/ma00062a035https://doi.org/10.1021/ma00062a035research-articleACS PublicationsRequest reuse permissionsArticle Views191Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Optical Transport Network Design for 5G Fixed Wireless Access (2019)

The fifth generation (5G) of mobile technology, 5G is anticipated to be a significant leap in the evolution of mobile communication. 5G will be designed to attain 1000 times higher data volumes, 10 times lower latency, and 100 times more connected devices than its predecessor, 4G. Due to 5Gs ability to sustain high bandwidth per unit area, 5G is considered to be a cost-efficient solution to provide fixed wireless access (FWA) to households on a large scale. FWA is seen as an attractive alternative for fixed broadband access in scenarios where last mile access based on wired technologies is not economically viable. While approaches for enhancing user experience in a 5G FWA environment are investigated in the research community, the problem of providing cost-effective high capacity transport for FWA deployments still remains a major challenge. This is particularly challenging due to diverse transport network architectures and requirements imposed by different 5G deployment models. This paper addresses this problem by formulating a generalized joint-optimization framework to simultaneously plan wireless access and optical transport for 5G FWA networks in order to minimize the deployment cost while meeting various network requirements. We demonstrate the applicability of the proposed framework by applying it to a real scenario with a range of deployment options and where different types of optical x-haul solutions are considered. The results provide a cornerstone for deployment strategies that will be imperative for realizing a future-proof and cost-effective broadband access network.
Abstract P4-03-06: Microenvironmental control of breast cancer subtype elicited by paracrine growth factors signaling (2017)

Abstract During cancer progression from an indolent stage to a clinically manifested disease, the surrounding microenvironment co-evolves into an activated state through continuous and dynamic paracrine communication between all constituent cell types that collectively sustain malignant growth. Hence, from a therapeutic perspective, tumors must be regarded as multi-cellular organs. Mesenchymal cells are highly plastic entities. Normal fibroblasts are described to counteract tumorigenesis by repressing cancer initiation. However, co-evolution of the malignant epithelium and its underlying stroma instigates activation of cancer-associated fibroblasts (CAFs) into a phenotype endorsing most, if not all, hallmarks of cancer progression. Through translational studies using breast cancer patient cohorts, genetically engineered mouse models (including patient derived xenografts), and single-cell RNA sequencing, we delineate a previously unappreciated role for CAFs as determinants of breast cancer prognosis and treatment response through specification of the molecular subtype of breast cancer. Expression of paracrine growth factors mediating malignant cell-CAF crosstalk in breast cancer was found to be associated with a hormone receptor-negative state. Genetic targeting of the signaling networks governing the interactions between tumor cells and CAFs confirmed their functional importance by prompting a delay in tumor growth, impaired extra-cellular matrix deposition and reduced angiogenesis. Importantly, our work holds therapeutic implications, as genetic or therapeutic targeting of CAF subsets resulted in conversion of basal-like/triple-negative breast tumors into a luminal state that conferred sensitivity to endocrine therapy in previously impervious tumors. Additionally, to mechanistically explore the heterogeneity of mesenchymal cells in breast tumors, we have made use of single cell RNA sequencing of isolated CAFs as a guide to divide cells into transcriptionally similar groups. Distinct clusters of different CAF subtypes were identified and found to denote diverse functions in the tumor microenvironment. In conclusion, therapeutic targeting of functional subsets of CAFs may be exploited as a refined strategy to improve patient benefit from established treatments by impinging on the stimulatory crosstalk between CAFs and their surrounding malignant microenvironment. Citation Format: Bocci M, Bartoschek M, Pietras K. Microenvironmental control of breast cancer subtype elicited by paracrine growth factors signaling [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P4-03-06.
Formation of Cobalt-BTA Complexes and Their Removal from Various Surfaces Relevant to Cobalt Interconnect Applications (2018)

The use of benzotriazole (BTA) during Co film planarization leads to the undesirable formation of insoluble Co-BTA complexes, which can be observed as organic residues on various surfaces after polishing. Here, we investigated the formation of Co-BTA complexes at different pH values and their adsorption and removal from Co, TiN, SiN, and SiO2 film surfaces relevant to Co interconnect applications. The stability constant, log Keq, of Co2+-BTA complex was determined from its spectroscopic properties and log Keq was found to lie between 2.7 and 3.9 in the pH range of 6 ∼ 12, much smaller than that of Co3+-ethylenediaminetetraacetic acid (EDTA) complexes (log Keq = 36.0). Using this data, and recognizing that potassium persulfate (K2S2O8) and EDTA can lead to oxidation and ligand exchange of Co2+-BTA complexes, respectively, we were able to remove Co-BTA complexes adsorbed on all films by exposing them to aqueous solutions of 50 mM EDTA, 1.5 wt% K2S2O8, and 1 mM sodium dodecylbenzenesulfonate (SDBS) at pH 12. SDBS was helpful in lowering ΔEcorr to about 10 mV for the Co/TiN couple as well as the corrosion currents of Co film.
Evolution of flow-oriented design strategies in the continuous preparation of pharmaceuticals (2020)

This review focuses on the flow-oriented design (FOD) in the multi-step continuous-flow synthesis of active pharmaceutical ingredients.
Encoding Enantiomeric Molecular Chiralities on Graphene Basal Planes (2022)

Graphene has demonstrated broad applications due to its prominent properties. Its molecular structure makes graphene achiral. Here, we propose a direct way to prepare chiral graphene by transferring chiral structural conformation from chiral conjugated amino acids onto graphene basal plane through π-π interaction followed by thermal fusion. Using atomic resolution transmission electron microscopy, we estimated an areal coverage of the molecular imprints (chiral regions) up to 64 % on the basal plane of graphene (grown by chemical vapor deposition). The high concentration of molecular imprints in their single layer points to a close packing of the deposited amino acid molecules prior to "thermal fusion". Such "molecular chirality-encoded graphene" was tested as an electrode in electrochemical enantioselective recognition. The chirality-encoded graphene might find use for other chirality-related studies and the encoding procedure might be extended to other two-dimensional materials.
High-density mesoscopic atom clouds in a holographic atom trap (2005)

We demonstrate the production of micron-sized high-density atom clouds of interest for mesoscopic quantum information processing. We evaporate atoms from $60\phantom{\rule{0.3em}{0ex}}\ensuremath{\mu}\mathrm{K}$, $3\ifmmode\times\else\texttimes\fi{}{10}^{14}\phantom{\rule{0.3em}{0ex}}\mathrm{atoms}∕{\mathrm{cm}}^{3}$ samples contained in a highly anisotropic optical lattice formed by interfering diffracted beams from a holographic phase plate. After evaporating to $1\phantom{\rule{0.3em}{0ex}}\ensuremath{\mu}\mathrm{K}$ by lowering the confining potential, in less than a second the atom density reduces to $8\ifmmode\times\else\texttimes\fi{}{10}^{13}\phantom{\rule{0.3em}{0ex}}{\mathrm{cm}}^{\ensuremath{-}3}$ at a phase space density approaching unity. Adiabatic recompression of the atoms then increases the density to levels in excess of $1\ifmmode\times\else\texttimes\fi{}{10}^{15}\phantom{\rule{0.3em}{0ex}}{\mathrm{cm}}^{\ensuremath{-}3}$. The resulting clouds are typically $8\phantom{\rule{0.3em}{0ex}}\ensuremath{\mu}\mathrm{m}$ in the longest dimension. Such samples are small enough to enable mesoscopic quantum manipulation using the Rydberg blockade and have the high densities required to investigate collision phenomena.
Biomechanics of Volunteers Subject to Loading by a Motorized Shoulder Belt Tensioner (2008)

Occupant size has a significant effect on retraction time to reposition the torso during shoulder belt tensioning. Larger vehicle occupants require more time because of a slower retraction velocity. The results are sufficiently simple that a lumped-mass model can predict tensioning kinetics.
A retinal prosthesis device based on an 80×40 hybrid microelectronic-microwire glass array (2004)

Retinal prosthesis now appears feasible based on a number of recent experiments demonstrating electrical stimulation of human retina in blind subjects. We are completing development of a neural stimulating array that can be customized to function as a retinal prosthesis device. The microelectronic device has an image format of 80/spl times/40 unit cells interfaced to the curved retinal surface via an array of hundreds of thousands of microwires in a glass matrix. The system architecture and development issues are discussed as well as the topic of biocompatibility. The test device will enable acute human experiments in an operating room environment to demonstrate a massively parallel interface between retinal tissue and a microelectronic array.
Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas. (1994)

We analyzed 47 primary sporadic human renal cell carcinomas (39 clear cell and 8 non-clear cell) for mutations of the von Hippel-Lindau (VHL) tumor suppressor gene using the polymerase chain reaction and single strand conformational polymorphism analysis of DNA. All of the positive cases in single strand conformational polymorphism analyses were further characterized by direct sequencing. Somatic mutations were detected in 22 (56%) of 39 clear cell renal carcinomas including 15 deletions, 3 insertions, 3 missense mutations, and 1 nonsense mutation. Nineteen of these mutations predicted to produce truncation of the VHL protein. These mutations mainly occurred in the last one-third region of exons 1, 2, and 3. In addition, loss of heterozygosity of the VHL gene was observed in 16 (84%) of 19 informative clear cell renal carcinomas. No somatic mutations were detected in 8 non-clear cell carcinomas. These results show that the VHL tumor suppressor gene is one of the major tumor suppressor genes in human renal cell carcinomas, especially in the clear cell subtype renal cell carcinoma. Clear cell carcinoma might be distinguished from other pathological types of renal cell carcinomas by molecular genetic techniques.
Galidesivir, a Direct-Acting Antiviral Drug, Abrogates Viremia in Rhesus Macaques Challenged with Zika Virus (2017)

Abstract Background Zika virus (ZIKV) was first isolated from a sentinel rhesus monkey in 1947. ZIKV infection in humans is associated with serious neurological and reproductive complications. No antiviral or protective vaccine is yet available. Galidesivir an adenosine analog is a potent viral RNA-dependent RNA polymerase inhibitor with demonstrated broad-spectrum antiviral activity. Methods We have conducted four pre-clinical studies in rhesus macaques to assess the safety, antiviral efficacy and dosing strategies of galidesivir against ZIKV infection. Collectively, we have challenged 70 rhesus macaques by various routes using 1x105 TCID50of a Puerto Rican ZIKV isolate. We have evaluated galidesivir therapy administered via IM injection as early as 90 minutes and up to 72 hours after subcutaneous (SC) ZIKV challenge, and as late as 5 days after intravaginal (IVAG) challenge. In these studies, we evaluated the efficacy of a range of loading and maintence doses of galidesivir. The highest dose evaluated has been a loading dose of 100mg/kg BID followed by a maintenance dose of 25mg/kg BID for nine days. We followed multiple endpoints, including ZIKV RNA levels in plasma, urine, saliva, and cerebrospinal fluid. Immune activation, complete blood counts, chemistries and galidesivir pharmacokinetics were also monitored. Results Galidesivir was well-tolerated in all studies. All untreated controls developed high-level plasma viremia, and had readily detectable ZIKV RNA in CSF, saliva and urine post-infection. Animals treated in the first 24 hours after SC ZIKV challenge did not develop plasma viremia and were either negative or had significantly reduced ZIKV RNA in bodily fluids. Animals treated with galidesivir later (up to 72 hours) were partially protected; they had detectable plasma ZIKV RNA, but the onset was delayed and/or magnitude significantly reduced compared with controls. Animals infected IVAG were protected by galidesivir treatment up until day 5 after infection, with no blood viremia and significant reductions in ZIKV RNA in the CSF as compared with controls. Conclusion Galidesivir dosing in rhesus macaques was well-tolerated and offered significant protection against ZIKV infection. These results warrant continued study and clinical evaluation. Disclosures R. Taylor, BioCryst Pharmaceuticals: Employee, Salary; S. MacLennan, BioCryst: Employee, Salary; M. Leonard, BioCryst: Employee, Salary; E. Giuliano, BioCryst: Employee, Salary; A. Mathis, BioCryst Pharmaceuticals: Employee, Salary; E. Berger, BioCryst: Employee, Salary; Y. Babu, BioCryst: Employee, Salary; W. Sheridan, BioCryst Pharmaceuticals: Employee, Salary
Piezoelectric control of spin quantum memories in a cryogenic programmable photonic circuit platform (2022)

We demonstrate piezoelectric strain control of diamond tin vacancy defects in cryogenic photonic integrated circuits fabricated in a 200 mm CMOS platform, enabling frequency tuning and control bandwidth above 20 GHz and 2 GHz, respectively.