gebhart/patrepeval huggingface dataset:
Response surface modeling approach for the assessment of the PHEV impact on the grid (2011)

This paper proposes an approach to characterize the plug-in hybrid electric vehicle (PHEV) behavior for assessing the impact of PHEVs on the grid based on naturalistic driving information. PHEV behavior is captured by response surfaces of the amount for electric energy consumption and the amount of fuel consumption at arrival with respect to the initial SOC and the driving distance. Response surfaces are created from detailed PHEV simulation results using representative cycles synthesized based on naturalistic driving data. The proposed approach enables computationally efficient prediction of the PHEV impact on the grid with large data-sets.
Abstract SY36-03: Intraoperative molecular imaging with protease-activated fluorescent imaging agents (2015)

Abstract Intra-operative detection of residual cancer in the tumor bed can be used to decrease the risk of a positive surgical margin, reduce the rate of re-excision, and tailor adjuvant therapy. LUM015 is a pegylated protease-activated imaging agent containing a near infrared fluorophore and quencher attached by a polypeptide linker. Using mouse models of soft tissue sarcoma (STS), we showed that LUM015 selectively localizes to the tumor and upon cleavage of the linker by proteases in the tissue, the quencher is released, allowing fluorescence to be detected. We recently completed a phase I clinical trial to test the safety of LUM015 in human patients with cancer. This open-label nonrandomized trial compared 3 dose cohorts (0.5, 1.0, and 1.5 mg/kg) of LUM015 in order to determine a safe dose of LUM015 that labels tumors in humans. A total of 15 subjects, 12 with STS and 3 with breast cancer, received IV LUM015 prior to surgical resection without any adverse pharmacological activity (APA). Quantitative fluorescence imaging of the resected tissues revealed that tumor fluorescence was significantly higher than corresponding normal tissue from the same patient (p&amp;lt;0.0001) with a mean tumor to normal fluorescence ratio of 5.4. Furthermore, within the study population, the distribution of tumor fluorescence values was significantly higher than those recorded for fat or muscle (p&amp;lt;0.009). We conducted comparative analyses of LUM015 pharmacodynamics in mouse and human subjects showing that biodistribution into tumors and activation by proteases is conserved across species. These studies revealed the presence of a novel, small molecule metabolite that correlates strongly with tissue fluorescence. Additional in vivo studies in mice and in vitro studies with mouse and human tissues showed that LUM015 is selectively distributed to and accumulates in tumors to result in increased fluorescence when compared to normal tissues. Citation Format: Melodi J. Whitley, Diana M. Cardona, Dan G. Blazer, Shelley Hwang, Rachel A. Greenup, Paul J. Mosca, Joan Cahill, Jeffrey K. Mito, Kyle C. Cuneo, Nicole Larrier, Erin O'Reilly, Ivan Spasojevic, Richard F. Riedel, William C. Eward, Linda G. Griffith, Moungi G. Bawendi, Jorge Ferrer, David B. Strasfeld, W. David Lee, Brian Brigman, David G. Kirsch. Intraoperative molecular imaging with protease-activated fluorescent imaging agents. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr SY36-03. doi:10.1158/1538-7445.AM2015-SY36-03
Anatomic Fitting of Total Artificial Hearts for In Vivo Evaluation (2013)

Successful anatomic fitting of a total artificial heart (TAH) is vital to achieve optimal pump hemodynamics after device implantation. Although many anatomic fitting studies have been completed in humans prior to clinical trials, few reports exist that detail the experience in animals for in vivo device evaluation. Optimal hemodynamics are crucial throughout the in vivo phase to direct design iterations and ultimately validate device performance prior to pivotal human trials. In vivo evaluation in a sheep model allows a realistically sized representation of a smaller patient, for which smaller third-generation TAHs have the potential to treat. Our study aimed to assess the anatomic fit of a single device rotary TAH in sheep prior to animal trials and to use the data to develop a three-dimensional, computer-aided design (CAD)-operated anatomic fitting tool for future TAH development. Following excision of the native ventricles above the atrio-ventricular groove, a prototype TAH was inserted within the chest cavity of six sheep (28-40 kg). Adjustable rods representing inlet and outlet conduits were oriented toward the center of each atrial chamber and the great vessels, with conduit lengths and angles recorded for future analysis. A three-dimensional, CAD-operated anatomic fitting tool was then developed, based on the results of this study, and used to determine the inflow and outflow conduit orientation of the TAH. The mean diameters of the sheep left atrium, right atrium, aorta, and pulmonary artery were 39, 33, 12, and 11 mm, respectively. The center-to-center distance and outer-edge-to-outer-edge distance between the atria, found to be 39 ± 9 mm and 72 ± 17 mm in this study, were identified as the most critical geometries for successful TAH connection. This geometric constraint restricts the maximum separation allowable between left and right inlet ports of a TAH to ensure successful alignment within the available atrial circumference.
Proceedings of the First ACM Workshop on Cyber-Physical Systems-Security and/or PrivaCy (2015)

It is our great pleasure to welcome you to the First ACM Workshop on Cyber-Physical Systems Security and PrivaCy (CPS-SPC) in conjunction with the 22nd ACM Conference on Computer and Communications Security in Denver, Colorado, USA. Our increased dependency on cyber-physical systems (CPS) has amplified concerns of cyber attacks on these systems. These transformative attack methods require additional research into secure control systems and related architectures of CPS. The majority of the published literature addressing the security and privacy of CPS reflect a field still in its infancy; as such, the overall principles, models, and theories for securing CPS have not yet emerged. It is hoped that this workshop will provide a focal point for the research community to begin addressing the security and privacy of CPS in a comprehensive and multidisciplinary manner and, in tandem with other efforts, build a comprehensive research roadmap. As a workshop, we expect to attract papers that reflect ongoing work that are still "works in progress". This first edition of the workshop aims to lay the foundations to become one of the premier forums for presentation of interdisciplinary research results and experience reports at the interface of control theory, information security, embedded and real-time systems and human factors applied to CPS. The mission of the workshop is to create a community of researchers focusing on diverse aspects of CPS Security and Privacy, and to provide researchers and practitioners a premiere forum to share their perspectives with others interested in interdisciplinary approaches to solve the challenging security and privacy problems in CPS. We received 20 submissions, and all papers were reviewed by at least three program committee members. 11 papers were accepted leading to a 55% acceptance rate.
YB-1: oncoprotein, prognostic marker and therapeutic target? (2012)

Hanahan and Weinberg have proposed the 'hallmarks of cancer' to cover the biological changes required for the development and persistence of tumours [Hanahan and Weinberg (2011) Cell 144, 646-674]. We have noted that many of these cancer hallmarks are facilitated by the multifunctional protein YB-1 (Y-box-binding protein 1). In the present review we evaluate the literature and show how YB-1 modulates/regulates cellular signalling pathways within each of these hallmarks. For example, we describe how YB-1 regulates multiple proliferation pathways, overrides cell-cycle check points, promotes replicative immortality and genomic instability, may regulate angiogenesis, has a role in invasion and metastasis, and promotes inflammation. We also argue that there is strong and sufficient evidence to suggest that YB-1 is an excellent molecular marker of cancer progression that could be used in the clinic, and that YB-1 could be a useful target for cancer therapy.
Intrinsic Signal Amplification by Type-III CRISPR-Cas Systems Provides a Sequence-Specific Viral Diagnostic (2020)

Abstract To combat viral pandemics, there is an urgent need for inexpensive new technologies that enable fast, reliable, and scalable detection of viruses. Here we repurposed the type III CRISPR-Cas system for sensitive and sequence specific detection of SARS-CoV-2 in an assay that can be performed in one hour or less. RNA recognition by type III systems triggers Cas10-mediated polymerase activity, which simultaneously generates pyrophosphates, protons and cyclic oligonucleotides. We show that amplified products of the Cas10-polymerase are detectable using colorimetric or fluorometric readouts.
Growth Hormone Response to Growth Hormone Releasing Factor in Alzheimer’s Disease (1989)

Because of the well-established reduction in the concentration of somatostatin in several brain areas of patients with histologically verified Alzheimer's disease, we sought to determine if growth hormone (GH) secretion is altered in Alzheimer's disease. In order to study this, we assessed the GH response to growth hormone releasing factor (GRF) in 8 patients with Alzheimer's disease and 8 age-matched controls. Although there was no difference between the magnitude of the GRF-induced GH response (delta max GH response or area under the curve) between the Alzheimer's disease patients and the controls, the Alzheimer's patients exhibited a delayed GH response to GRF.
Supplementary Table 1 from The High-Mobility Group A1a/Signal Transducer and Activator of Transcription-3 Axis: An Achilles Heel for Hematopoietic Malignancies? (2023)

Supplementary Table 1 from The High-Mobility Group A1a/Signal Transducer and Activator of Transcription-3 Axis: An Achilles Heel for Hematopoietic Malignancies?
Correction to 2-Furoylglycine as a Candidate Biomarker of Coffee Consumption (2016)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to 2-Furoylglycine as a Candidate Biomarker of Coffee ConsumptionSilke S. Heinzmann*, Elaine Holmes, Sunil Kochhar, Jeremy K. Nicholson, and Philippe Schmitt-KopplinCite this: J. Agric. Food Chem. 2016, 64, 46, 8958Publication Date (Web):November 11, 2016Publication History Published online11 November 2016Published inissue 23 November 2016https://pubs.acs.org/doi/10.1021/acs.jafc.6b04833https://doi.org/10.1021/acs.jafc.6b04833correctionACS PublicationsCopyright © 2016 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views594Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (155 KB) Get e-Alertsclose Get e-Alerts
Covalent and electrostatic incorporation of amines into hypercrosslinked polymers for increased CO2 selectivity (2018)

ABSTRACT Two methods of incorporating functional groups rich in nitrogen into low cost microporous hypercrosslinked polymers (HCPs) have been evaluated and the effects on the carbon dioxide CO 2 /N 2 IAST selectivity were measured. Electrostatic incorporation of an ammonium salt into a sulfonic acid‐containing HCP polymer afforded a static CO 2 uptake of 2.5 mmol g −1 with a CO 2 /N 2 IAST selectivity of 42:1 at 1 bar and 298 K. Using column breakthrough measurements with a 15:85 CO 2 /N 2 mixture at 298 K and 1 bar, a selectivity of 17:1 was obtained. However, varying the counterion resulted in polymers with lower CO 2 /N 2 selectivity values. Decoration of the parent polymer with CO 2 ‐philic imidazole followed by electrostatic ammonium salt incorporation blocked some of the micropores reducing the selectivity which re‐emphasizes the role and importance of pore width for CO 2 /N 2 selectivity. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018 , 56, 2513–2521
Supplementary Table 9 from Somatic Mosaic Chromosomal Alterations and Death of Cardiovascular Disease Causes among Cancer Survivors (2023)

&lt;p&gt;Supplementary Table 9: The effect of mosaic loss of Y chromosome on death of cardiovascular disease causes, coronary artery disease causes, from cancer and any cause of death&lt;/p&gt;
Nomenclatural issues concerning cultured yeasts and other fungi: why it is important to avoid unneeded name changes (2021)

The unambiguous application of fungal names is important to communicate scientific findings. Names are critical for (clinical) diagnostics, legal compliance, and regulatory controls, such as biosafety, food security, quarantine regulations, and industrial applications. Consequently, the stability of the taxonomic system and the traceability of nomenclatural changes is crucial for a broad range of users and taxonomists. The unambiguous application of names is assured by the preservation of nomenclatural history and the physical organisms representing a name. Fungi are extremely diverse in terms of ecology, lifestyle, and methods of study. Predominantly unicellular fungi known as yeasts are usually investigated as living cultures. Methods to characterize yeasts include physiological (growth) tests and experiments to induce a sexual morph; both methods require viable cultures. Thus, the preservation and availability of viable reference cultures are important, and cultures representing reference material are cited in species descriptions. Historical surveys revealed drawbacks and inconsistencies between past practices and modern requirements as stated in the International Code of Nomenclature for Algae, Fungi, and Plants (ICNafp). Improper typification of yeasts is a common problem, resulting in a large number invalid yeast species names. With this opinion letter, we address the problem that culturable microorganisms, notably some fungi and algae, require specific provisions under the ICNafp. We use yeasts as a prominent example of fungi known from cultures. But viable type material is important not only for yeasts, but also for other cultivable Fungi that are characterized by particular morphological structures (a specific type of spores), growth properties, and secondary metabolites. We summarize potential proposals which, in our opinion, will improve the stability of fungal names, in particular by protecting those names for which the reference material can be traced back to the original isolate.
Saturable absorbing dynamics of GaInN multiquantum well structures (2011)

We evaluated saturation energies and absorption recovery time dependent on reverse-bias voltage for a waveguide-coupled GaInN multiquantum well saturable absorber in a bisectional laser structure. When the applied reverse-bias was increased from 5 to 20 V, the saturation energy at 405 nm monotonically increased from 5 to 14 pJ; the linear absorption coefficient at 405 nm showed the same dependence. These dependences are different from those observed in an AlGaAs multiquantum well. The absorption recovery time was shortened to 3 ps when a highly reverse-bias voltage of 20 V was applied.
A Simple Approach to Quantify Accuracy of Power Systems Inertia (2022)

Power network stability is a goal that all system operators try to achieve during their daily management. However, the recent spread of renewable energy sources obstacles such a goal. This is mainly due to the replacement of synchronous machines with static-conversion-based ones. Consequently, the grid is now experiencing (i) lower levels of inertia that help during anomalous operations; (ii) lower predictability of the power generation. As for inertia, it is becoming, day after day, a critical parameter used to assess the network's capability to sustain power/frequency variations, due to faults or disturbances. Therefore, system operators are more and more relying on such parameter for implementing their countermeasures. However, the inertia accuracy assessment is still an open issue, and it is seldom associated with the inertia estimates. To this purpose, this paper tries to quantify the uncertainty to be associated with inertia. This is done starting from its definition and the main uncertainty contributions. To achieve this goal, the Monte Carlo method is applied to realistic scenarios. From the results, it clearly emerges the importance of running rigorous uncertainty analysis. This is particularly true for those critical parameters like inertia.
LKB1 as a Gatekeeper of Hepatocyte Proliferation and Genomic Integrity during Liver Regeneration (2018)

Liver kinase B1 (LKB1) is involved in several biological processes and is a key regulator of hepatic metabolism and polarity. Here, we demonstrate that the master kinase LKB1 plays a dual role in liver regeneration, independently of its major target, AMP-activated protein kinase (AMPK). We found that the loss of hepatic Lkb1 expression promoted hepatocyte proliferation acceleration independently of metabolic/energetic balance. LKB1 regulates G<sub>0</sub>/G<sub>1</sub> progression, specifically by controlling epidermal growth factor receptor (EGFR) signaling. Furthermore, later in regeneration, LKB1 controls mitotic fidelity. The deletion of Lkb1 results in major alterations to mitotic spindle formation along the polarity axis. Thus, LKB1 deficiency alters ploidy profile at late stages of regeneration. Our findings highlight the dual role of LKB1 in liver regeneration, as a guardian of hepatocyte proliferation and genomic integrity.
Antibodies from Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis (2023)

&lt;p&gt;Antibody concentration and blocking conditions&lt;/p&gt;
Core‐shell emulsion copolymerization of styrene and acrylonitrile on polystyrene seed particles (1984)

Abstract Seeded emulsion copolymerization of an azeotropic composition of styrene (St) and an acrylinitrile (AN) comonomer mixture in polystyrene (PS) seed at different polymerization temperature of 55–75°C were investigated. The kinetic data showed a transition temperature at 65°C, above which the activation energy of polymerization is low, 6.1 Kcal/mol, compared with 9.8 Kcal/mol below it. The particle‐size results and thin layer chromatographic (TLC) data showed two types of particle of different composition and morphology in the final latex system: a smaller size of (St–AN) copolymer and a larger size of core‐PS and (St–AN) copolymer shell, with a zone of PS grafted (St–AN) copolymer in between. Various polymerization parameters, that is emulsifier concentration, type of seed particle and its size, and monomer/polymer ratio, were studied and their effects on particle size and particle morphology were examined. The percent of grafted core‐PS was 10% below a polymerization temperature of 65°C and 40% above that temperature. By adjusting the size and number of the seed particles, monomer‐polymer ratio, and emulsifier concentration conditions were established in which a final copolymer latex with “perfect” core‐shell morphology was achieved.
Reduced foreign body response at nitric oxide-releasing subcutaneous implants (2020)

The tissue response to nitric oxide (NO)-releasing subcutaneous implants is presented. Model implants were created by coating silicone elastomer with diazeniumdiolate-modified xerogel polymers capable of releasing NO. The host tissue response to such implants was evaluated at 1, 3, and 6 weeks and compared to that of uncoated silicone elastomer blanks and xerogel-coated controls incapable of releasing NO. Delivery of NO (~375 pmol/cm2 of implant surface area) reduced the foreign body collagen capsule (“scar tissue”) thickness by >50% compared to uncoated silicone elastomer after 3 weeks. The chronic inflammatory response at the tissue/implant interface was also reduced by >30% at NO-releasing implants after 3 and 6 weeks. Additionally, CD-31 immunohistochemical staining revealed ~77% more blood vessels in proximity to NO-releasing implants after 1 week compared to controls. These findings suggest that conferring NO release to subcutaneous implants may promote effective device integration into healthy vascularized tissue, diminish foreign body capsule formation, and improve the performance of indwelling medical devices that require constant mass transport of analytes (e.g., implantable sensors).
Distributed nonlinear modeling and stability analysis of axial compressor stall and surge (2005)

This paper presents a nonlinear formulation of the Moore-Greitzer rotating stall model that is suitable for control analysis and design. The model is validated by comparing stall inception experiments to simulated stall inception transients. The shape of the nonlinear compressor characteristic is shown to be a primary determinant of stall inception transient behavior. A Lyapunov stability analysis procedure is then presented. This procedure allows basins of attraction to be determined for various system operating points. Examples are given, and implications for design of rotating stall/surge control systems are discussed.
Nanoskiving Core–Shell Nanowires: A New Fabrication Method for Nano-optics (2014)

This paper describes the fabrication of functional optical devices by sectioning quantum-dot-in-nanowires systems with predefined lengths and orientations. This fabrication process requires only two steps, embedding the nanowires in epoxy and using an ultramicrotome to section them across their axis ("nanoskiving"). This work demonstrates the combination of the following four capabilities: (i) the control of the length of the nanowire sections at the nanometer scale; (ii) the ability to process the nanowires after cutting using wet etching; (iii) the possibility of modifying the geometry of the wire by varying the sectioning angle; and (iv) the generation of as many as 120 consecutive slabs bearing nanowires that have uniform size and approximately reproducible lateral patterns and that can subsequently be transferred to different substrates. The quantum dots inside the nanowires are functional and of a high optical quality after the sectioning process and exhibit photoluminescent emission with wavelengths in the range of 650-710 nm.