gebhart/patrepeval huggingface dataset:
Maximum Power Point Tracking Algorithm for Gridtied Photovoltaic Cascaded Hbridge Inverter (2015)

In this article, a maximum power point tracking algorithm properly adapted for a grid­tied photovoltaic multi-level inverter is presented. The inverter structure is based on a single­phase cascaded H­bridge configuration, where each power cell is supplied by an individual photovoltaic panel. The dedicated maximum power point tracking algorithm is based on a suitable hysteresis band, which defines the proper boundaries for maximum power point tracking references to ensure both stable inverter operation and maximum photovoltaic power extraction. The inverter control method is a mixed staircase pulse-width modulation based on a sorting algorithm. Some experimental tests have been performed by using a laboratory prototype of a single­phase five­level photovoltaic cascaded H­bridge inverter, which is controlled by means of dSPACE real­time hardware platform (ds1006, dSPACE GmbH, Paderborn, Germany), where the control section is implemented on a field-programmable gate array (Xilinx Virtex5, Xilinx, Inc., San Jose, CA). The experimental results confirm that the proposed control is able to efficiently track the maximum power point while assuring good performance in terms of harmonic distortion and power factor in both standard and mismatch conditions.
<title>Report from the military sciences working group</title> (2002)

Q1: What is Nanoscience? Possible attempts at a definition: - Dimensional based definition (minimum feature size) - Pertaining to atomic or to molecular assemblages - Pertaining to interfaces: not bulk-like properties
Epithelial Cell Adhesion Molecule Regulates Tumor Initiation and Tumorigenesis via Activating Reprogramming Factors and Epithelial-Mesenchymal Transition Gene Expression in Colon Cancer (2012)

Epithelial cell adhesion molecule (EpCAM) is highly expressed in epithelial-transformed neoplasia and tumor-initiated cells (TICs), but the role that EpCAM plays in the stemness properties of TICs is still unclear. Here we show that EpCAM and reprogramming factors (c-Myc, Oct4, Nanog, and Sox2) were concomitantly elevated in TICs, which were shown to have superior self-renewal, invasiveness, and tumor-initiating abilities. Elevation of EpCAM enhanced tumorsphere formation and tumor initiation. Knockdown of EpCAM inhibited the expressions of reprogramming factors and epithelial-mesenchymal transition genes, thereby suppressing tumor initiation, self-renewal, and invasiveness. In addition, EpCAM, especially intracellular domain of EpCAM (EpICD), bound to and activated the promoter of reprogramming factors. Treatment with the inhibitor of γ-secretase (DAPT) led to the blockage of the expressions of reprogramming factors and epithelial-mesenchymal transition genes, which was accompanied by the reduction of tumor self-renewal and invasion. Furthermore, the increased release of EpEX enhanced production of EpICD and regulated the expression of reprogramming factors. Together, these findings suggest that EpCAM plays an important role in regulating cancer-initiating abilities in TICs of colon cancer. This discovery can be used in the development of new strategies for cancer therapy.
Next-generation diagnostic test for dengue virus detection using an ultrafast plasmonic colorimetric RT-PCR strategy (2023)

The current global COVID-19 pandemic once again highlighted the urgent need for a simple, cost-effective, and sensitive diagnostic platform that can be rapidly developed for distribution and easy access in resource-limited areas. Here, we present a simple and low-cost plasmonic photothermal (PPT)-reverse transcription-colorimetric polymerase chain reaction (RTcPCR) for molecular diagnosis of dengue virus (DENV) infection. The assay can be completed within 54 min with an estimated detection limit of 1.6 copies/μL of viral nucleic acid. The analytical sensitivity and specificity of PPT-RTcPCR were comparable to that of the reference RT-qPCR assay. Moreover, the clinical performance of PPT-RTcPCR was evaluated and validated using 158 plasma samples collected from patients suspected of dengue infection. The results showed a diagnostic agreement of 97.5% compared to the reference RT-qPCR and demonstrated a clinical sensitivity and specificity of 97.0% and 100%, respectively. The simplicity and reliability of our PPT-RTcPCR strategy suggest it can provide a foundation for developing a field-deployable diagnostic assay for dengue and other infectious diseases.
Isotope enrichment and stereochemistry of the products from the reaction of electronically excited iodine monochloride with cis- and trans-1,2-dibromoethylene (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsotope enrichment and stereochemistry of the products from the reaction of electronically excited iodine monochloride with cis- and trans-1,2-dibromoethyleneSaswati Datta, John I. Brauman, and Richard N. ZareCite this: J. Am. Chem. Soc. 1979, 101, 24, 7173–7176Publication Date (Print):November 1, 1979Publication History Published online1 May 2002Published inissue 1 November 1979https://pubs.acs.org/doi/10.1021/ja00518a008https://doi.org/10.1021/ja00518a008research-articleACS PublicationsRequest reuse permissionsArticle Views62Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Electrochemical spectral induced polarization modeling of artificial sulfide-sand mixtures (2014)

ABSTRACT We examined the sensitivity of the electrochemical spectral induced polarization (SIP) model developed by Wong to the oxidation extent of pyrite and pyrrhotite minerals disseminated in silica sand. The sensitivity of this model to the oxidation of sulfide minerals was mainly related to the model parameters defining the ratio of the active to the inactive passive ions (c2/co) dissolved in the pore water, and the variation of the current reaction parameters α and β. The increase in these parameters as well as in the associated exchange current densities, io(α) and io(β) was consistent with an increase in the activation of the charge transfer at the metal-electrolyte interface, resulting in the decrease in polarization of such an interface, which was reflected by a decrease in the SIP phase response as previously argued by Wong. Under this premise, the model described fairly well measurements below 500 Hz from a laboratory experiment, being consistent with the depletion of the SIP phase response associated with the oxidation degree promoted on the disseminate sulfides analyzed here. This suggested that electrochemical modeling of SIP measurements can provide information to assess the oxidation state of sulfides and also to infer the formation of passivating layers coating the metal minerals during oxidation-dissolution processes. Our results suggested a possible alternative for the monitoring of mine waste deposits producing acid mine drainage and the stability of sequestered harmful metals during remedial treatments by means of the SIP method.
Automated generation of visual discourse (1999)

Visual presentations can help us understand information better. However, handcrafting customized, effective visual presentations requires much skill, time and effort. To present information in a timely, customized manner, we develop comprehensive and systematic methodologies to automate the visual design process. In particular, we focus on automatically creating coherent, versatile, and interactive visual discourse. We use the term visual discourse to refer to a series of connected visual displays, of which a single display or a series of static displays may be considered as special cases. A coherent visual discourse has smooth transitions between displays, consistent designs within and among displays, and effective visual unification among various components. A versatile visual discourse is capable of representing a wide range of information through different visual media and visual techniques. An interactive visual discourse encourages and supports user interactivity. 
This thesis addresses a set of research issues vital to the creation of coherent, versatile, and interactive visual discourse. We describe how to characterize presentation data, model presentation context, and classify presentation tasks. To equip presentation systems with visual design knowledge, we discuss the design and formal representation of a presentation design language, which covers a wide variety of visual patterns, visual techniques, and visual design principles at multiple levels of abstraction. We also present a powerful and efficient inferencing paradigm to reason about various conditions and infer a visual design. To demonstrate the coverage and utility of our research, we describe the design and implementation of a system called IMPROVISE (Illustrative Metaphor PROduction in VISual Environments). We have used IMPROVISE to automatically create coherent visual presentations in two different domains. In one domain, IMPROVISE is used as a stand-alone system for a computer network management application to provide users with cohesive visual explanations about network structures and behaviors. IMPROVISE is also employed as a graphics generation component in a collaborative effort with Columbia's Natural Language Processing group and Knowledge Representation group to produce multimedia summaries of patient medical records, containing coordinated text, speech, and graphics.
Engineering the optical response of nanodipole antennas using equivalent circuit representations of core-shell particle loads (2013)

The feasibility of tuning the optical response of a dipole nanoantenna using plasmonic core-shell particles is demonstrated. The proposed scheme consists of a two-step tuning process. First, it is demonstrated that when the gap between the nanodipole arms is loaded by a homogeneous dielectric sphere, the configuration exhibits effective material properties that can be described by a mixing rule, thereby allowing it to be effectively mapped onto an equivalent circuit topology. An additional degree of tunability is introduced by substituting the load consisting of a homogeneous sphere with one represented by a two-layer core-shell particle. An electrically small core-shell particle offers the advantage that it functions as a tunable nanocircuit element with properties that depend on the material constitution of the particle as well as its volume fraction. Effective medium theory is employed, and through rigorous analysis the resulting core-shell nanoparticle properties are then mapped onto an equivalent circuit topology. The complete derivation is presented for the total equivalent circuit model that corresponds to this two-step tuning process. Full-wave numerical predictions of the nanoantenna&#x2019;s extinction cross section are presented that validate the results obtained through the equivalent circuit-based representation of the loaded antenna. The proposed methodology illustrates the inherent tuning capabilities that core-shell particles can offer. Additionally, a novel compact and efficient scheme is introduced in order to map general nanoantenna loads onto equivalent circuit representations. The proposed approach permits the examination of the nanodipole antenna&#x2019;s performance in its transmitting mode; therefore it completely eliminates the need for time-consuming full-wave simulations of loaded nanoantenna structures. At the same time, it provides the optical designer with the capability to custom-engineer the nanoantenna&#x2019;s response through fast and accurate circuit-based analysis.
The role of IL-17/IL-6 axis in the development of chronic lymphocytic leukemia. (2015)

e22119 Background: The tumor microenvironment (TME) is critical to the survival of tumor B cells in chronic lymphocytic leukemia (CLL). Bone marrow mesenchymal stem cells (BMMSCs) and the cytokines they produced are important components of TME. Methods: 49 Patients with various stages of CLL were included. BMMSCs were co-cultured with human CLL cells with or without the presence of IL-17. Peripheral blood mononuclear cells from CLL patients were injected into NSG mice and IL-6/IL-17 were delivered daily. Student t test and Pearson product-moment correlation were used in statistical analysis. Results: CLL cells survived better when co-cultured with BMMSCs. ELISA array revealed a high concentration of IL-6 in co-culture system. Inhibition of IL-6 by Actemra decreased CLL cell survival in the co-culture. IL-6 production can be induced by IL-17 in both BMMSCs and CLL cells. In a xenograft animal model, BMMSCs and its culture supernatant promoted the engraftment of CLL cells via inducing IL-6. Human recombinant IL-17 administration also increased CLL engraftment through inducing IL-6. The plasma of CLL patients had elevated levels of IL-6 (16.3 ± 8.1 vs. 2.6 ± 2.1 pg/mL, p < 0.001) and IL-17 (9.2 ± 8.0 vs. 1.4 ± 1.1 pg/mL, p < 0.001), compared to healthy controls. There was a linear correlation between the levels of IL-6 and IL-17 in CLL patients (p < 0.0001), but not in the healthy controls. The patients who received Fludarabine based chemotherapy (n = 18) had higher concentration of IL-6 (21.77 ± 12.25 vs. 10.33 ± 11.51 pg/mL, p < 0.001) and IL-17 (12.78 ± 8.20 vs. 4.42 ± 5.59 pg/mL, p < 0.001) compared to those untreated (n = 13). Patients with low levels IgA or IgM (n = 14) had elevated IL-6 concentration in their plasma compared to the controls (n = 33) (22.51 ± 13.00 vs. 10.20 ± 9.10 pg/mL, p = 0.001). IL-6 and IL-17 levels were not associated with tumor cell load, CD38 expression or β2-microglobulin in our cohort of patients. Conclusions: Our study suggests an important role of IL-6 in survival of CLL cells. High levels of IL-17 in CLL patients may be responsible for the elevation of IL-6. CLL patients with higher IL-6 or IL-17 levels tend to have more aggressive diseases. IL-17/IL-6 axis could be a therapeutic target in CLL treatment.
Data from Epigenetic Silencing Affects l-Asparaginase Sensitivity and Predicts Outcome in T-ALL (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Biological explanation for discrepancies in patient-related response to chemotherapy depending on the underlying oncogenic events is a promising research area. TLX1- or TLX3-deregulated T-cell acute lymphoblastic leukemias (T-ALL; TLX1/3&lt;sup&gt;+&lt;/sup&gt;) share an immature cortical phenotype and similar transcriptional signatures. However, their prognostic impacts differ, and inconsistent clinical outcome has been reported for TLX3. We therefore hypothesized that the overlapping transcriptional profiles of TLX1&lt;sup&gt;+&lt;/sup&gt; and TLX3&lt;sup&gt;+&lt;/sup&gt; T-ALLs would allow identification of candidate genes, which might determine their distinct clinical outcomes.&lt;/p&gt;Experimental Design:&lt;p&gt;We compared TLX1&lt;sup&gt;+&lt;/sup&gt; and TLX3&lt;sup&gt;+&lt;/sup&gt; adult T-ALL outcome in the successive French national LALA-94 and GRAALL-2003/2005 multicentric trials and analyzed transcriptomic data to identify differentially expressed genes. Epigenetic regulation of asparagine synthetase (&lt;i&gt;ASNS&lt;/i&gt;) and &lt;i&gt;in vitro&lt;/i&gt; l-asparaginase sensitivity were evaluated for T-ALL cell lines and primary samples.&lt;/p&gt;Results:&lt;p&gt;We show that TLX1&lt;sup&gt;+&lt;/sup&gt; patients expressed low levels of &lt;i&gt;ASNS&lt;/i&gt; when compared with TLX3&lt;sup&gt;+&lt;/sup&gt; and TLX-negative patients, due to epigenetic silencing of &lt;i&gt;ASNS&lt;/i&gt; by both DNA methylation and a decrease of active histone marks. Promoter methylation of the &lt;i&gt;ASNS&lt;/i&gt; gene correlated with l-asparaginase sensitivity in both T-ALL cell lines and patient-derived xenografts. Finally, &lt;i&gt;ASNS&lt;/i&gt; promoter methylation was an independent prognostic factor for both event-free survival [HR, 0.42; 95% confidence interval (CI), 0.24–0.71; &lt;i&gt;P&lt;/i&gt; = 0.001] and overall survival (HR, 0.40; 95% CI, 0.23–0.70; &lt;i&gt;P&lt;/i&gt; = 0.02) in 160 GRAALL-2003/2005 T-ALL patients and also in an independent series of 47 LL03-treated T lymphoblastic lymphomas (&lt;i&gt;P&lt;/i&gt; = 0.012).&lt;/p&gt;Conclusions:&lt;p&gt;We conclude that &lt;i&gt;ASNS&lt;/i&gt; methylation status at diagnosis may allow individual adaptation of l-asparaginase dose.&lt;/p&gt;&lt;/div&gt;
Doc2-mediated superpriming supports synaptic augmentation (2018)

Various forms of synaptic plasticity underlie aspects of learning and memory. Synaptic augmentation is a form of short-term plasticity characterized by synaptic enhancement that persists for seconds following specific patterns of stimulation. The mechanisms underlying this form of plasticity are unclear but are thought to involve residual presynaptic Ca<sup>2+</sup> Here, we report that augmentation was reduced in cultured mouse hippocampal neurons lacking the Ca<sup>2+</sup> sensor, Doc2; other forms of short-term enhancement were unaffected. Doc2 binds Ca<sup>2+</sup> and munc13 and translocates to the plasma membrane to drive augmentation. The underlying mechanism was not associated with changes in readily releasable pool size or Ca<sup>2+</sup> dynamics, but rather resulted from superpriming a subset of synaptic vesicles. Hence, Doc2 forms part of the Ca<sup>2+</sup>-sensing apparatus for synaptic augmentation via a mechanism that is molecularly distinct from other forms of short-term plasticity.
Local saliency-inspired binary patterns for automatic recognition of multi-view facial expression (2016)

In this paper, we propose a novel scheme for automatic recognition of facial expressions captured from both fronto-parallel and non-fronto-parallel cameras i.e., multi-view facial expressions (MVFE). The proposed scheme introduce a Local Saliency-inspired Binary Pattern (LSiBP) feature to recognize MVFE. First view-specific approximated saliency likelihood map (ASLM) is derived during training of our model. ASLM is determined from the 2D structure tensor representation of faces. The distribution of saliency likelihoods of pixels along with pixel intensities are analyzed in extracting LSiBP features from a face. Such LSiBP features are utilized for training and testing of view-specific SVM classifiers. Extensive experiments are performed on datasets of both posed and unconstrained spontaneous expressions of MVFE. Our scheme outperforms state-of-the-arts by at least 1% to recognize MVFE.
Modelling of oxygen diffusion and consumption in an XLPE cableinsulation for nuclear power applications using an oxidationdependentdiffusion-reaction approach (2015)

Nuclear power plants generate a significant part of the world’s electrical power consumption. However, many plants are nearing the end of their designed lifetime, and to extend the lifetime it is important to verify that every component can withstand the added service time. This includes polymeric materials, which become brittle with time. By predicting their lifetime and monitoring their condition, unnecessary downtime of the plant can be avoided, and secure operation can be ensured. The lifetime can be predicted by extrapolating results from accelerated ageing to service conditions, or by simulation of the degradation process.In this study, lifetime predictions through extrapolation were performed on samples of a polyvinyl chloride (PVC) core insulation and an acrylonitrile butadiene rubber (NBR) membrane, which were thermally aged in air. The lifetime of the PVC cable was predicted using Arrhenius extrapolation, and using a method based on Langmuir, Clausius-Clapeyron, and Kirchhoff’s equations.The lifetime of the NBR membrane was predicted using extrapolation in the temperature domain using an Arrhenius approach coupled with an extrapolation in pressure-domain, yielding realistic lifetimes.Two cable insulations, one made from crosslinked polyethylene (XLPE) and the other from ethylene propylene rubber (EPR) were aged under the simultaneous effect of elevated temperature and γ-radiation investigated using several condition monitoring techniques. In particular, two non-destructive techniques, dielectric spectroscopy and nuclear magnetic resonance, showed promising results be developed and used in situ.Finally, a computer model simulating the diffusion and consumption of oxygen in XLPE was developed, based on assumptions that diffusion, consumption and solubility were dependent on the total degree of oxidation. The model showed promise for further development.
Symmetry-protected topological exceptional chains in non-Hermitian crystals (2023)

Abstract In non-Hermitian systems, defective band degeneracies called exceptional points can form exceptional lines (ELs) in 3D momentum space in the absence of any symmetries. However, whether the presence of symmetries can affect the EL configurations had rarely been discussed. Here we show that a natural orientation can be assigned to every EL according to the eigenenergy braiding around it, and we establish the source-free principle of ELs stating that the number of ELs ingoing and outgoing from the junction must be conserved. Based on this principle, we discover that three crystalline-symmetry-based mechanisms can stabilize the junction of ELs, resulting in the formation of various types of exceptional chains (ECs). We further demonstrate that ECs can be observed in prototypical non-Hermitian photonic crystals. Our results combine the effect of non-Hermitian spatiotemporal symmetry and topology to pave the way for understanding and manipulating the morphology of ELs in non-Hermitian crystalline systems.
Pharmacy-based management for depression in adults (2019)

We found no evidence of a difference between pharmacy-based management for depression in adults compared with treatment as usual in facilitating depression symptom change. Based on numbers of participants leaving the trials early, there may be no difference in acceptability between pharmacy-based management and controls. However, there was uncertainty due to the low-certainty evidence.
ChemInform Abstract: MULTIPHOTON DISSOCIATION OF MOLECULES WITH LOW POWER CONTINUOUS WAVE INFRARED LASER RADIATION (1978)

Abstract Durch einen 70 eV Elektronenstrahl wird in der Quellregion einer ICR‐Zelle aus Diethylether das Protonen‐gebundene Dimere Et 2 O‐H + ‐OEt 2 erzeugt.
[AEDG peptide regulates human circadian rhythms genes expression during pineal gland accelerated aging.] (2020)

Night work provides biorhythms desynchronization, disorder of melatonin-producing function and accelerated pineal gland aging. One of the promising geroprotectors restoring the pineal melatonin synthesis is the AEDG (Ala-Glu-Asp-Gly) peptide. AEDG peptide increases in 1,7 times the 6-sulfatoxymelatonin (6-SOMT) excretion in the urine of middle-aged people. Moreover, AEDG peptide normalized circadian Clock and Csnk1e genes hyper expression in leukocytes in 1,9-2,1 times and increases the Cry2 gene hypo expression in peripheral blood lymphocytes in 2 times in people with reduced melatonin-producing epiphysis function. The geroprotective effect of the AEDG peptide is based on its ability to restore the epiphysis melatonin-producing function by means regulation of human circadian genes expression.