gebhart/patrepeval huggingface dataset:
Morphological Attributes Govern Carbon Dioxide Reduction on N-Doped Carbon Electrodes (2019)

The morphology of electrode materials is often overlooked when comparing different carbon-based electrocatalysts for carbon dioxide reduction. To investigate the role of morphological attributes, we studied polymer-derived, interconnected, N-doped carbon structures with uniformly sized meso or macropores, differing <i>only</i> in the pore size. We found that the carbon dioxide reduction selectivity (versus the hydrogen evolution reaction) increased around three times just by introducing the porosity into the carbon structure (with an optimal pore size of 27 nm). We attribute this change to alterations in the wetting and CO<sub>2</sub> adsorption properties of the carbon catalysts. These insights offer a new platform to advance CO<sub>2</sub> reduction performance by only morphological engineering of the electrocatalyst.
Type 4 Cardiorenal Syndrome: Diagnosis and Treatment (2015)

The clinical presentation of, and diagnostic approach taken for, a 63-year-old man with worsening dyspnea, chest heaviness and widespread lower limb edema, leading to a diagnosis of type 4 cardiorenal syndrome, is presented. The most appropriate approach at point of care is thoroughly discussed.
Adhesion energy can regulate vesicle fusion and stabilize partially fused states (2012)

Release of neurotransmitters from nerve terminals occurs by fusion of synaptic vesicles with the plasma membrane, and this process is highly regulated. Although major molecular components that control docking and fusion of vesicles to the synaptic membrane have been identified, the detailed mechanics of this process is not yet understood. We have developed a mathematical model that predicts how adhesion forces imposed by docking and fusion molecular machinery would affect the fusion process. We have computed the membrane stress that is produced by adhesion-driven vesicle bending and find that it is compressive. Further, our computations of the membrane curvature predict that strong adhesion can create a metastable state with a partially opened pore that would correspond to the 'kiss and run' release mode. Our model predicts that the larger the vesicle size, the more likely the metastable state with a transiently opened pore. These results contribute to understanding the mechanics of the fusion process, including possible clamping of the fusion by increasing molecular adhesion, and a balance between 'kiss and run' and full collapse fusion modes.
Software-Based Time-Aware Shaper for Time-Sensitive Networks (2019)

This paper presents the design, implementation, and evaluation of a time-aware shaper, which is a traffic shaper specifically designed for IEEE 802.1Qbv-compliant time-sensitive networks. The proposed design adopts a software-based approach rather than using a dedicated custom logic chip such as an ASIC or FPGA. In particular, the proposed approach includes a run-time scheduler and a network interface card (NIC) that supports a time-based transmission scheme (i.e., launch-time feature). The run-time scheduler prefetches information (i.e., gate control entry) ahead of time from a given gate control list. With the prefetched information, the scheduler determines a launch time for each frame, and the NIC controls the time at which the transmission of each frame is started in a highly punctual manner. Evaluation results show that the proposed shaper triggers transmission of multiple time-sensitive streams at their intended timings in accordance with a given gate control list, even in the presence of high-bandwidth background traffic. Furthermore, we compare the timing accuracy of frame transmission with and without use of the launch-time feature of the NIC. Results indicate that the proposed shaper significantly reduces jitter of time-sensitive streams (to less than 0.1 μs) unlike a baseline implementation that does not use the launch-time feature.
Building e-Science Portals: A Service Oriented Architecture (2006)

Grids are built by communities who need a shared cyberinfrastructure to make progress on the critical problems they are currently confronting. An e-science portal is a conventional Web portal that sits on top of a rich collection of web services that allow a community of users access to shared data and application resources without exposing them to the details of Grid computing. In this chapter we describe a service-oriented architecture to support this type of portal.
Text Messages Sent to Household Tuberculosis Contacts in Kampala, Uganda: Process Evaluation (2018)

The fidelity of a one-time text message (SMS) intervention to increase the uptake of household tuberculosis contact investigation and linkage to care was extremely low, a fact only discoverable through detailed process evaluation. This study suggests the need for systematic process monitoring and reporting of implementation fidelity in both research studies and programmatic interventions using mobile communications to improve health.
Developing Miniature Force-Sensing Technologies for Measuring the Forces Applied to a Computer Mouse (2000)

Force-sensing technologies, 1.4 − 2.5 mm thick, were developed to measure the forces applied to the button and sides of a computer mouse. A force-sensing computer mouse was developed, built and tested for force measurement accuracy. The force-sensing technology could accurately measure the forces applied to the sides of a mouse and identify the location of force application. The force-sensing technology also accurately measured the forces applied to the mouse button with slight measurement errors at low forces. The force-sensing technologies developed in this study were made from commercially available materials, were relatively low cost and will be readily exportable to different mouse designs. These force-sensing technologies should assist manufacturers, designers and researchers in better understanding how various hand held devices and tools are gripped and operated.
A Commonly Recognized Simian Immunodeficiency Virus Nef Epitope Presented to Cytotoxic T Lymphocytes of Indian-Origin Rhesus Monkeys by the Prevalent Major Histocompatibility Complex Class I Allele Mamu-A*02 (2001)

The ability to monitor vaccine-elicited CD8(+) cytotoxic T-lymphocyte (CTL) responses in simian immunodeficiency virus (SIV)- and simian-human immunodeficiency virus (SHIV)-infected rhesus monkeys has been limited by our knowledge of viral epitopes predictably presented to those lymphocytes by common rhesus monkey MHC class I alleles. We now define an SIV and SHIV Nef CTL epitope (YTSGPGIRY) that is presented to CD8(+) T lymphocytes by the common rhesus monkey MHC class I molecule Mamu-A*02. All seven infected Mamu-A*02(+) monkeys evaluated demonstrated this response, and peptide-stimulated interferon gamma Elispot assays indicated that the response represents a large proportion of the entire CD8(+) T-lymphocyte SIV- or SHIV-specific immune response of these animals. Knowledge of this epitope and MHC class I allele substantially increases the number of available rhesus monkeys that can be used for testing prototype HIV vaccines in this important animal model.
Stabilization and implementation of the fast transversal filter (2003)

A new rescue technique to stabilize the fast transversal filter (FTF) using the most efficient recursive least squares (RLS) algorithm and to implement the stabilized FTF on the commercially available DSP56000, DSP32, and TMS320C30 digital signal processors (DSPs) is presented. Long-term stability testing is performed by configuring FTF to predict second-order autoregressive process with different eigenvalue spreads of the input autocorrelation matrix. Experimental results show that the FTF works well with this rescue technique.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
APOE genotype affects the pre‐synaptic compartment of glutamatergic nerve terminals (2012)

Apolipoprotein E (APOE) genotype affects outcomes of Alzheimer's disease and other conditions of brain damage. Using APOE knock-in mice, we have previously shown that APOE-ε4 Targeted Replacement (TR) mice have fewer dendritic spines and reduced branching in cortical neurons. As dendritic spines are post-synaptic sites of excitatory neurotransmission, we used APOE TR mice to examine whether APOE genotype affected the various elements of the glutamate-glutamine cycle. We found that levels of glutamine synthetase and glutamate uptake transporters were unchanged among the APOE genotypes. However, compared with APOE-ε3 TR mice, APOE-ε4 TR mice had decreased glutaminase levels (18%, p < 0.05), suggesting decreased conversion of glutamine to glutamate. APOE-ε4 TR mice also had increased levels of the vesicular glutamate transporter 1 (20%, p < 0.05), suggesting that APOE genotype affects pre-synaptic terminal composition. To address whether these changes affected normal neurotransmission, we examined the production and metabolism of glutamate and glutamine at 4-5 months and 1 year. Using high-frequency (13)C/(1)H nuclear magnetic resonance spectroscopy, we found that APOE-ε4 TR mice have decreased production of glutamate and increased levels of glutamine. These factors may contribute to the increased risk of neurodegeneration associated with APOE-ε4, and also act as surrogate markers for Alzheimer's disease risk.
Evaluating health facility access using Bayesian spatial models and location analysis methods (2019)

The methods in this paper incorporate OHCA spatial risk factors and OHCA coverage to identify spatial regions most in need of resources. These methods can be used to help understand how AED allocation methods affect OHCA accessibility, which is of significant practical value for communities when deciding AED placements.
Immunological Characterization of an Exopolysaccharide from the Staphylococcus aureus Strain Smith Diffuse (1987)

Exopolysaccharides (EXPs) of Staphylococcus aureus are associated with virulence in animal models. An EXP from the S. aureus strain Smith diffuse was previously detected in 64.3% of S. aureus clinical isolates. EXP was isolated from culture supernatants of this strain after DNAase, RNAase, phosphodiesterase I and lysostaphin treatment, and was further purified by cation-exchange and molecular-sieve chromatography. Isoelectric focusing revealed a pI of 3.6 for the EXP while the pI of teichoic acid was less than 2.7. Crossed immunoelectrophoresis with homologous Smith diffuse antisera indicated that the EXP contained two immunological components. A major precipitin line persisted after the antisera had been absorbed with the non-EXP-producing variant strain, Smith compact, while the second component was removed. Tandem immunoelectrophoresis also demonstrated that the EXP was distinct from teichoic acid. The EXP contained 2-amino-2-deoxyglucuronic acid, glucose, mannose and galactose. No fatty acids or nucleic acids were present and total protein content was less than 2%. Teichoic acid could not be demonstrated in the EXP, thus further substantiating the immunological studies. S. aureus EXP isolated by the present method can be used for further serological and virulence studies.
Command and Control Automation - MIP and MSC2 FOSC (2001)

The Multilateral Interoperability Program's work has been the a great leap forward in the coalition arena just as the Multi-Service Command And Control Flag Officer Steering Committee's work has been instrumental in bringing the Services together to discuss tactical interoperability and work to solve the hard problems. One of the most interesting aspects of these two undertakings has been the method of defining C2 requirements. The service tradition of working Service requirements first, then joint requirements, and finally multinational requirements is a long-standing sequential process that mimics the implementation process. Through these two efforts it is clear that this long practiced sequence is a questionable method for producing true interoperability.
Breathable, Antistatic and Superhydrophobic PET/Lyocell Fabric (2015)

The objective of this study was to develop a breathable and antistatic superhydrophobic PET/lyocell fabric by simple finishing with polymeric fluorocarbon siloxane. To find an optimum concentration of the finish agent, four different concentrations of fluorocarbon finish agent were applied on three different types of fabrics; lyocell 100%, PET 100%, and PET/lyocell blend (50%/50%). Static water contact angle (WCA), shedding angle, and water repellency tests were measured to evaluate the wettability and hydrophobicity of treated fabrics. A PET/lyocell blend fabric treated with 40 g/L fluorocarbon finish agent exhibited superhydrophobic characteristics with WCA of 153.6° and shedding angle of 9.5° resulting from its lowed surface energy and multi-scale roughness. The effects of fluorocarbon finish on fabric moisture regain, electrostatic property, water vapor transmission rate (WVTR), and air permeability were evaluated as parameters for clothing comfort. PET/lyocell blend fabric treated with fluorocarbon exhibited significantly lower static electricity and higher moisture regain than the treated PET fabric. WVTR and air permeability were maintained after the finish. The blended fabric achieved noteworthy combination of antistatic and superhydrophobic properties. The functionality of finished PET and PET/lyocell fabrics, measured by WCA, shedding angle, and water repellency rate, was maintained until 10 washing cycles.
A Practical Method for the Synthesis of Sialyl α-Glycosides (1996)

Addition of 2,4-dimethylbenzenesulfenyl chloride to sialic acid glycal gives crystalline 2-chloro-3-thiosialic acid 3 in 85% yield. Reaction of 3 with sodium thiomethoxide in acetonitrile at 0 °C affords the sialic acid donor α-2-(methylthio)-3-thiosialic acid 4 in quantitative yield. Sialylation of glycosyl acceptors 9 and 10 with 4 in the presence of phenylsulfenyl triflate (PST) as promotor in CH3CN at −40 °C gives α-sialosides in good yield and excellent stereoselectivity. No β-sialosides are formed in either case. Removal of the auxiliary 3-(2,4-dimethylphenyl)thio group is achieved in high yield using Ph3SnH and AIBN in refluxing toluene. Protected GM3 trisaccharide and 6-sial-2-yllactose were obtained on a gram scale.
Novel Poly(p-xylylenes):  Thin Films with Tailored Chemical and Optical Properties (2002)

Chemical vapor deposition polymerization is used to prepare submicron thin films of poly(p-xylylenes) with distinct chemical and optical properties. The polymers are prepared from 13 different [2.2]paracyclophanes with variable degrees of substitution and functionalities including hydroxy, methoxy, amino, triflate, or trifluoroacetyl groups. The chemical composition of the poly(p-xylylenes) is in good accordance with expected chemical structures as confirmed by X-ray photoelectron spectroscopy, microanalysis, and reflection−absorption infrared spectroscopy. For all polymers, basic optical properties, such as extraordinary and ordinary indices of refraction, are reported and reveal optical anisotropy of the coatings. Experimental data correlate well with data generated by a uniaxial Cauchy dispersion model. Furthermore, a distinct correlation between refractive indices and the electronic properties of the functional groups is observed. Similarly, optical birefringence depends on the nature of the functional group as significant variation in optical birefringence was found among the reported poly(p-xylylenes).
Targeting Mitochondrial Factor Smac/DIABLO as Therapy for Multiple Myeloma (MM). (2004)

Abstract Mitochondrial signaling is an important component of chemotherapy-induced apoptosis in cancer cells. Stress-inducers trigger the following sequence of events: Smac (second mitochondria-derived activator of caspases)/ DIABLO is released from the mitochondrial inner membrane to cytosol; activated/cytosolic Smac binds to XIAP, a protein belonging to the family of IAPs (Inhibitors of apoptosis proteins), thereby abrogating its inhibitory effects on caspase-9 and resulting in activation of caspase-9-mediated apoptotic cascade. IAPs play a key role in regulating the apoptotic signaling, and overexpression of IAPs confer chemoresistance in various tumor types. Here we show that a low molecular weight synthetic Smac mimetic (Novartis) by virtue of its ability to bind and inhibit IAPs, block the growth of MM cell lines, including those resistant to conventional agents including dexamethasone, melphalan or doxorubicin. Examination of purified patient MM cells demonstrated similar results. In contrast, no significant toxicity of Smac mimetic was noted against normal peripheral blood mononuclear cells. Moreover, Smac mimetic also did not affect viability of MM patient-derived bone marrow stromal cells (BMSCs). Treatment of MM cells overexpressing anti-apoptotic protein Bcl2 with Smac mimetic significantly decreases their viability. Importantly, combined treatment of MM cells with Smac mimetic and Tumor necrosis factor-related apoptosis inducing ligand (TRAIL, Apo-2 ligand) trigger synergistic anti-MM activity, without significant toxicity in normal cells. Finally, Smac mimetic enhances the anti-MM activity of conventional Melphalan. Collectively, these findings provide the rationale for clinical evaluation of Smac mimetic alone and in combination with Melphalan or TRAIL, to enhance MM cell killing, overcome drug-resistance, and improve patient outcome in MM.
A CMOS full-wave rectifer with threshold compensation based on inherent body-voltage control (2016)

An RF rectifier operating at 868 MHz is presented, which uses a threshold-voltage compensation based on an inherent control of the body voltage. Indeed, the proposed solution enhances circuit performance in terms of power conversion efficiency (PCE) and sensitivity, by properly driving transistor bulks without additional components. A 10-stage CMOS full-wave rectifier was implemented in a 0.13-μm CMOS technology for a typical RF harvesting application. The circuit is capable of delivering 2.4 V and 1 μA to the output load, while achieving a PCE performance of 38% with an RF input power as low as -22 dBm.
ESAT‐6 and CFP‐10 in Clinical versus Environmental Isolates ofMycobacterium kansasii (2005)

Mycobacterium kansasii consists of 5 genetically distinct groups, of which 2 are associated with human disease. Determinants of the differences in virulence are unknown. Potential genes of interest are esat-6 and cfp-10, which are associated with virulence of Mycobacterium tuberculosis and Mycobacterium bovis but are lacking in bacille Calmette-Guérin and in most environmental mycobacteria (M. kansasii is an exception). We investigated esat-6 and cfp-10 genes in 22 clinical and 14 environmental isolates of M. kansasii. Both were present in all isolates; each genetic group had its own characteristic Southern-blot pattern corresponding to a highly conserved fingerprint pattern. Nucleotide sequences of the genes differed 12.6% and 10.1%, respectively, from the M. tuberculosis homologues, but the deduced amino acid sequences were <5% different. In vitro, clinical and environmental genotypes of M. kansasii expressed CFP-10 and ESAT-6. Thus, virulence of M. kansasii is not directly related to esat-6 and cfp-10 genes or gene expression.
Poly(3,4-ethylenedioxypyrrole):  Organic Electrochemistry of a Highly Stable Electrochromic Polymer (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTPoly(3,4-ethylenedioxypyrrole): Organic Electrochemistry of a Highly Stable Electrochromic PolymerCarleton L. Gaupp, Kyukwan Zong, Philippe Schottland, Barry C. Thompson, Christopher A. Thomas, and John R. ReynoldsView Author Information Center for Macromolecular Science and Engineering, Department of Chemistry, University of Florida, Gainesville, Florida 32611 Cite this: Macromolecules 2000, 33, 4, 1132–1133Publication Date (Web):February 4, 2000Publication History Received24 September 1999Revised20 December 1999Published online4 February 2000Published inissue 1 February 2000https://pubs.acs.org/doi/10.1021/ma9916180https://doi.org/10.1021/ma9916180rapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views1934Altmetric-Citations112LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Conjugated polymers,Organic polymers,Plastics,Polymers,Redox reactions Get e-Alerts
Old Years, New Years, Welcomes, and Social Media (2017)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTOld Years, New Years, Welcomes, and Social MediaRobin D. RogersView Author Information McGill UniversityCite this: Cryst. Growth Des. 2017, 17, 1, 1–2Publication Date (Web):January 4, 2017Publication History Published online4 January 2017Published inissue 4 January 2017https://pubs.acs.org/doi/10.1021/acs.cgd.6b01873https://doi.org/10.1021/acs.cgd.6b01873editorialACS PublicationsCopyright © 2017 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views593Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (3 MB) Get e-AlertscloseSUBJECTS:Nanomaterials,Power Get e-Alerts