gebhart/patrepeval huggingface dataset:
Effect of the host polymer on the nanomechanical and morphological properties of templated polymer films (2013)

Atomic force microscopy and nanoindentation have been applied to the study of thin molecularly templated polymer films. The template was chosen to be the readily hydrogen‐bonded cotinine molecule and three different polymer hosts, Elvamide® nylon, Nylon‐6, and poly(4‐vinylphenol) were compared. The host polymer was shown to affect the nature of the template‐host interaction resulting in varying surface morphologies and differences in the nanohardness. These observations were shown to reflect differences in the underlying interaction chemistry, specifically, whether or not the polymer may be imprinted in the film production process. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 877‐883, 2013
A continuous compact MOSFET model for SOI with automatic transitions between fully and partially depleted device behavior (2002)

A fully continuous compact SOI model for circuit simulations, that automatically accounts for the correct body depletion condition, is presented. Unlike previously reported models that are derived for either fully-depleted (FD) or partially-depleted (PD) devices, the model described here accounts for the possible transitions between FD and PD behavior during the device operation.
Agent-Based Simulation for Interconnection-Scale Renewable Integration and Demand Response Studies (2015)

This paper collects and synthesizes the technical requirements, implementation, and validation methods for quasi-steady agent-based simulations of interconnection-scale models with particular attention to the integration of renewable generation and controllable loads. Approaches for modeling aggregated controllable loads are presented and placed in the same control and economic modeling framework as generation resources for interconnection planning studies. Model performance is examined with system parameters that are typical for an interconnection approximately the size of the Western Electricity Coordinating Council (WECC) and a control area about 1/100 the size of the system. These results are used to demonstrate and validate the methods presented.
Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Leukemia Cells (2017)

Abstract Cancer cells may be addicted to DNA repair, which is supported by more selective targeting of tumor cells by recently developed novel drugs/compounds against specific DNA repair mechanisms. The success of PARP1 inhibitor olaparib in BRCA1 and BRCA2-deficient breast and/or ovarian tumors has established a proof-of-concept for personalized cancer therapy utilizing synthetic lethality. Unfortunately, therapeutic effect is usually short-lived and tumor cells become unresponsive to PARP1 inhibitors. Recently using personalized medicine approach we discovered that cohorts of acute and chronic leukemias display deficiencies in BRCA1/2-RAD51 -mediated homologous recombination (HR) repair, but these leukemia cells could not be completely eradicated by PARP1 inhibitors (Nieborowska-Skorska et al., J.Clin.Invest., 2017). Therefore, more radical elimination of BRCA1/2-deficient leukemia cells is required to prevent time-dependent emergence of PARP1 inhibitor-resistant/refractory clones. Alternative mechanisms of DNA repair may emerge in tumor cells exhibiting genetic and/or epigenetic deficiencies in the BRCA protein network to protect cells from lethal effect of DNA double strand breaks (DSBs). It has been suggested that RAD52-RAD51 provides an alternative HR pathway in BRCA1/2-deficient cells. We detected that RAD52-RAD51 mediated HR repair of DSBs remained active in PARP1 inhibitor-treated BRCA1/2-deficient tumor cells. Therefore, we hypothesized that RAD52-RAD51 pathway may be a potential escape route from PARP1 inhibitor-mediated synthetic lethality in BRCA1/2-deficient cells and that targeting RAD52 should enhance synthetic lethal effect of PARP1 inhibitor. Here we show that simultaneous short-term targeting of PARP1 and RAD52 with dominant-negative mutants or small molecule inhibitors resulted in synergistic accumulation of DSBs and/or cell death of BRCA1/2-deficient solid tumor and leukemia cells, but not BRCA/1/2-proficient cells. Moreover, long-term simultaneous treatment with PARP1 inhibitor and RAD52 inhibitor completely eradicated BRCA1/2-deficient tumor cells in vitro. Combination of PARP1 inhibitor + RAD52 inhibitor was not toxic for normal cells and tissues. Moreover, Parp1-/-;Rad52-/- double-knockout mice are indistinguishable from their wild-type littermates. SImultaneous targeting of PARP1 and RAD52 also reduced leukemia burden in vivo. BCR-ABL1-induced BRCA1-deficient Parp1-/-;Rad52-/- leukemias displayed prolonged latency when compared to Parp1-/- or Rad52-/- counterparts. Finally, the combination of PARP1 inhibitor and RAD52 inhibitor exerted synergistic activity against BRCA1/1-deficient primary leukemia xenografts in immunodeficient mice. In conclusion, we postulate that addition of RAD52 inhibitor may dramatically improve therapeutic outcome of BRCA1/2-deficient leukemias treated with PARP1 inhibitor. Disclosures Valent: Celgene: Honoraria, Research Funding; Novartis: Honoraria.
Imaging the Local Nonlinear Viscoelastic Properties of Soft Tissues: Initial Validation and Expected Benefits (2022)

Imaging tissue mechanical properties has shown promise in noninvasive assessment of numerous pathologies. Researchers have successfully measured many linear tissue mechanical properties in laboratory and clinical settings. Currently, multiple complex mechanical effects such as frequency-dependence, anisotropy, and nonlinearity are being investigated separately. However, a concurrent assessment of these complex effects may enable more complete characterization of tissue biomechanics and offer improved diagnostic sensitivity. In this work, we report for the first time a method to map the frequency-dependent nonlinear parameters of soft tissues on a local scale. We recently developed a nonlinear elastography model that combines strain measurements from arbitrary tissue compression with radiation-force-based broadband shear wave speed (WS) measurements. Here, we extended this model to incorporate local measurements of frequency-dependent shear modulus. This combined approach provides a local frequency-dependent nonlinear parameter that can be obtained with arbitrary, clinically realizable tissue compression. Initial assessments using simulations and phantoms validate the accuracy of this approach. We also observed improved contrast in nonlinearity parameter at higher frequencies. Results from ex-vivo liver experiments show 32, 25, 34, and 38 dB higher contrast in elastograms than traditional linear elasticity, elastic nonlinearity, viscosity, and strain imaging methods, respectively. A lesion, artificially created by injection of glutaraldehyde into a liver specimen, showed a 59% increase in the frequency-dependent nonlinear parameter and a 17% increase in contrast ratio.
Speed of Efficacy and Delayed Toxicity Characteristics of Fast-Acting Fire Ant (Hymenoptera: Formicidae) Baits (2006)

Efficacy and speed of action of fire ant (Hymenoptera: Formicidae) baits that claim fast control of colonies were compared with a standard bait. More than 85% of red imported fire ant, Solenopsis invicta Buren, laboratory colonies provided bait containing the active ingredient indoxacarb died within 3 d, and all colonies were dead in 6 d. Standard bait containing hydramethylnon resulted in death of 60% of the colonies in 9 d. Bait containing spinosad did not cause colony death. Under field conditions, one-half of the areas treated with the indoxacarb bait did not have any active fire ant nests within 3 d, whereas 11 d was needed to reach the same level of control with the hydramethylnon bait. Spinosad had a maximum of 17% of the treated areas without nests after 3 d. The delay in death of S. invicta adults treated in the laboratory with the indoxacarb and spinosad baits was shorter than the standard hydramethylnon bait, which had mortality similar to the traditional delayed toxicity criterion of < 15% mortality after 24 h and > 89% mortality over the test period. Indoxacarb caused mortality of 57% at 24 h and 100% at 48 h; however, visual symptoms of toxicity were not readily observed for at least 8 h before the abrupt increase in death. Spinosad caused 96% mortality by 24 h, and initial mortality became apparent at 4 h. Time required for death of 15% of a treated population (LT15) of spinosad, indoxacarb, and hydramethylnon was 3, 9, and 16 h, respectively. Delayed toxicity characteristics of the fast-acting indoxacarb bait may be useful for the development of other fast-acting ant baits.
Performance of the CMS drift tube chambers with cosmic rays (2010)

MICINN and CPAN (Spain); Swiss Funding Agencies (Switzerland); NSC (Taipei); TUBITAK and TAEK (Turkey); STFC (United Kingdom); DOE and NSF (USA). Individuals have received support from the Marie-Curie IEF program (European Union); the Leventis Foundation; the A. P. Sloan Foundation; and the Alexander von Humboldt Foundation.
Reconfigurable Solar Converter: A Single-Stage Power Conversion PV-Battery System (2012)

This paper introduces a new converter called reconfigurable solar converter (RSC) for photovoltaic (PV)-battery application, particularly utility-scale PV-battery application. The main concept of the new converter is to use a single-stage three-phase grid-tie solar PV converter to perform dc/ac and dc/dc operations. This converter solution is appealing for PV-battery application, because it minimizes the number of conversion stages, thereby improving efficiency and reducing cost, weight, and volume. In this paper, a combination of analysis and experimental tests is used to demonstrate the attractive performance characteristics of the proposed RSC.
Development of Oxygen Semipermeable Membrane Using Mixed Conductive Perovskite-Type Oxides (Part 1) (1989)

Preparation of porous substrates (discs) of La0.6Sr0.4CoO3 (LSCO) was investigated as a part of the study on an oxygen semipermeable device based on mixed conductive perovskite-type oxides. Of the several methods attempted, sintering of compacts of an LSCO powder-methylcellulose (MC) mixture and an LSCO-carbon fiber (CF) mixture gave discs with irregular macro-pores which tended to grow parallel to the disc surface or with straight penetrating channels with a uniform diameter, respectively. However, none of them exhibited sufficiently large (physical) air permeability. On the other hand, sintering of a compact of LSCO powder was far more effective if an adequate starting powder was chosen. Thus, when the LSCO powder calcined at 1400°C (LSCO (1400)) with the particle size larger than 10μm was used, the disc sintered at 1400°C showed high air permeability through penetrating channels consisting of a network of intergranular pores. Furthermore, when LSCO (1400) powder was sieved to 44-74μm, the sintered disc had uniform-sized open pores with a diameter of 20 to 30μm, which provided porous structure resistant to heat treatment and high permeability of air. The disc appeared to be suitable as a porous support on which thin membrane of oxygen semipermeable perovskite-type oxides was formed.
Heavy Si doping in AlGaAs near modulation-doped heterointerfaces (1999)

We propose that the local Fermi-level modulation that occurs at heterojunctions enables the achievement of a higher carrier concentration in a limited thin layer than that can be achieved in a thick layer. We studied heterojunctions consisting of Si-doped AlGaAs (Al=20%) (AlGaAs:Si)/InGaAs (In=20%) grown by metalorganic chemical vapor deposition to demonstrate effectiveness of our doping method. The thickness and doping concentration of the AlGaAs:Si were designed carefully not to form a neutral region in the structure. We obtained a maximum electron concentration Nd=2.4×1019 cm−3 at 300 K in AlGaAs:Si; this value is about seven times higher than that reported for AlGaAs:Si so far. We believe that the AlGaAs/InGaAs heterojunction positions the Fermi level in the AlGaAs:Si (near the heterojunction) far from the conduction-band minimum, and that this effectively suppresses creation of compensation centers in AlGaAs:Si, then all the Si donors in AlGaAs:Si are activated.
ASON/GMPLS Extension for Reservation and Time Based Automatic Bandwidth Service (2006)

The draft presents ASON/GMPLS architecture extension for reservation
and time based automatic bandwidth services. It introduces additional
service intelligence function to the control plane. It describes the
service scenarios and procedures for automatic bandwidth service. It
also discusses the potential services enabled by the service
intelligence function.
COVID‐19 risk in breast cancer patients receiving CDK4/6 inhibitors: literature data and a monocentric experience (2021)

Substantial changes in the management of cancer patients have been required worldwide in response to the COVID-19 pandemic. Beyond the due details on the primitive cancer site and setting at diagnosis, these latter adaptions are most commonly exemplified by a significant reduction in the screening of asymptomatic subjects, delays in elective surgery and radiotherapy for primary tumors, and dose reductions and/or delays in systemic therapy administration. Advanced breast cancer patients with hormonal receptor positive, HER2 negative tumors are usually treated with endocrine therapy combined with CDK 4/6 inhibitors as first- and second-line treatment. During the pandemic, experts' recommendations have suggested the omission or delay of CDK 4/6 inhibitors delivery, or a careful evaluation of their real need due to the hypothesized increased risk of SARS-Cov-2 infection and disease possibly related to neutropenia. The inherent literature is sparse and inconsistent. We herein present data on the use of CDK 4/6 inhibitors during the pandemic. The evidence reported punctually reflects the experience matured at our Institution, a comprehensive cancer centre, on the topic of interest.
De novo pathogenic variant in TUBB2A presenting with arthrogryposis multiplex congenita, brain abnormalities, and severe developmental delay (2017)

Disorders of brain formation can occur from pathogenic variants in various alpha and beta tubulin genes. Heterozygous pathogenic variants in the beta tubulin isotype A gene, TUBB2A, have been recently implicated in brain malformations, seizures, and developmental delay. Limited information is known regarding the phenotypic spectrum associated with pathogenic variants in this gene given the rarity of the condition. We report the sixth individual with a de novo heterozygous TUBB2A pathogenic variant, who presented with a severe neurological phenotype along with unique features of arthrogryposis multiplex congenita, optic nerve hypoplasia, dysmorphic facial features, and vocal cord paralysis, thereby expanding the gene-related phenotype.
Prognostics Framework for Power Semiconductor IGBT Modules through Monitoring of the On-State Voltage (2019)

This paper presents a literature review and an overview of original contributions on diagnostic and prognostic technologies for IGBT power modules based on the monitoring of the on-state voltage (Von). &#x0D; First, different kinds of Von sensing circuits are discussed in terms of specifications, implementation, performance and cost. A low-cost and practical circuit is experimentally demonstrated. Then, a method is presented and evaluated for estimating wire-bond degradation. Wire-bond lift-off is the most common wear-out mechanism for industrial power semiconductor IGBT modules. It is effectively detected by measuring Von at the Zero Temperature Coefficient (ZTC) current value. Next, a method is presented to estimate the die temperature. Knowing the die temperature allows estimating the thermo-mechanical stress imposed to the wire-bonds. It is demonstrated to be feasible with ±3°C accuracy/precision using after careful calibration of Von as a Temperature Sensitive Electrical Parameter (TSEP). Finally, an algorithm is presented to process the information generated from the monitoring of Von and estimate the Remaining Useful Life (RUL). It considers Von evolution prior the first wire-bond lift-off and it combines both condition-based and damage accumulation based predictions.&#x0D; The major contribution of this paper is to present, for the first time, a complete framework for diagnostics and prognostics of power semi-conductor IGBT modules.
Near-visible bright-soliton Kerr comb generation in dispersion-engineered lithium niobate coupled optical microresonators (2019)

We present an optimized, dispersion-engineered, air-clad, coupled lithium niobite optical-microresonator-based configuration for bright-soliton wideband (40 nm bandwidth at -70 dB window) Kerr-comb generation at the near-visible spectrum.
Development of Wide Angle Fovea Lens for High-Definition Imager Over 3 Mega Pixels (2018)

This paper presents a high-quality wide-angle fovea lens, i.e., the WAF lens, for the autonomous robot's and vehicle's super-sensing vision system. The WAF lens is well-known in the field of robotic vision with respect to its unique design concept, biologically-inspired from a visual system of the primates. The WAF lens achieves the following two conflicting properties in imaging simultaneously: (1) wide field of view (FOV) and (2) high magnification factor (although only the central FOV achieves it partially). In this paper, the authors designs the WAF lens for the high-resolution photosensitive imaging chip more than 3M pixels. For this design, we decide the following targets on the assumption of applying this WAF lens for the stereo vision system: (1) The WAF lens can measure a very far distance over 100m ahead from the imager accurately. (2) The WAF lens can observe approximately 100-degree wide FOV on the same time. We produce a prototype of this WAF lens with much higher optical performance than our previous developments. The compound system of the prototype includes four aspherical surfaces in its front part to project enough bright images so that the WAF lens is available not only at daytime but also in dark situations at night. The authors experiment and demonstrate the projection tests using the prototype, and discuss about the results as the inspection of this challenging development.
Electrophysiological Studies of the Feasibility of Suprachoroidal-Transretinal Stimulation for Artificial Vision in Normal and RCS Rats (2004)

STS is less invasive in the retina than stimulation through epiretinal or subretinal implants. STS can generate focal excitation in retinal ganglion cells in normal animals and in those with degenerated photoreceptors, which suggests that this method of retinal stimulation is suitable for artificial vision.
High aspect ratio quarter-micron electroless copper integrated technology (1997)

We present recent results of electroless Cu line and CoWP barrier/protection layer depositions with emphasis on copper encapsulation at low temperature for on-chip wiring of very high aspect ratio. We present a profile study of barrier/seed layers covered with thin (/spl sim/100 nm) electroless Cu films by SEM cross sections and step coverage in trenches and vias as a function of aspect ratio.
Circumventing Pericyclic Reactions To Realize Insertion Polymerization of Cyclobutene Derivatives (2006)

ADVERTISEMENT RETURN TO ISSUECommunication to the...Communication to the EditorNEXTCircumventing Pericyclic Reactions To Realize Insertion Polymerization of Cyclobutene DerivativesKeitaro Seto and Bruce M. NovakView Author Information Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695 Cite this: Macromolecules 2006, 39, 20, 6785–6788Publication Date (Web):August 31, 2006Publication History Received20 July 2006Revised14 August 2006Published online31 August 2006Published inissue 1 October 2006https://pubs.acs.org/doi/10.1021/ma0616413https://doi.org/10.1021/ma0616413rapid-communicationACS PublicationsCopyright © 2006 American Chemical SocietyRequest reuse permissionsArticle Views541Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Catalysts,Hydrocarbons,Monomers,Polymerization,Polymers Get e-Alerts
VidCat: an image and video analysis service for personal media management (2013)

Cloud-based storage and consumption of personal photos and videos provides increased accessibility, functionality, and satisfaction for mobile users. One cloud service frontier that is recently growing is that of personal media management. This work presents a system called VidCat that assists users in the tagging, organization, and retrieval of their personal media by faces and visual content similarity, time, and date information. Evaluations for the effectiveness of the copy detection and face recognition algorithms on standard datasets are also discussed. Finally, the system includes a set of application programming interfaces (API’s) allowing content to be uploaded, analyzed, and retrieved on any client with simple HTTP-based methods as demonstrated with a prototype developed on the iOS and Android mobile platforms.
CNN-based super-resolution adapted to quantization parameters (2020)

In video transmission, the videos are encoded and decoded. At that time, bit control is performed by specifying the quantization parameter (QP). The video undergoes various processing to remove redundancy and then orthogonally transforms the video signal into the frequency domain. The frequency domain coefficients are then quantized and transmitted. At that time, by specifying QP, the quantization step is changed, and the amount of data can be changed. In an opinion, a codec using super-resolution is proposed. At the CNN based super-resolution of encoded images, the degradation of the input image due to encoding depends on the characteristics of the image. As a result, there is a problem that the weights of the optimal CNN for the input image changes depending on the image characteristics. In order to solve this problem, we propose a method to adaptively perform super-resolution corresponding to image degradation.