gebhart/patrepeval huggingface dataset:
Temperature dependence of the properties of DBR mirrors used in surface normal optoelectronic devices (1992)

The variation in the center wavelength of distributed Bragg reflectors used in optoelectronic devices, such as surface emitting lasers and Fabry-Perot modulators, is measured as the temperature of the mirrors changes over the range 25 degrees C to 105 degrees C. An analytic expression for the shift in center wavelength with temperature is presented. The mirrors measured are made of InP/InGaAsP ( lambda /sub gap/=1.15 mu m), GaAs/AlAs, and Si/SiN/sub x/. The linear shifts in center wavelength are 0.110+or-0.003 nm/ degrees C, 0.087+or-0.003 nm/ degrees C, and 0.067+or-0.007 nm/ degrees C for the InP/InGaAsP, GaAs/AlAs, and Si/SiN mirrors, respectively. Based on these data, the change in penetration depth with temperature is calculated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Basic principles of STT-MRAM cell operation in memory arrays (2013)

For reliable operation, individual cells of an STT-MRAM memory array must meet specific requirements on their performance. In this work we review some of these requirements and discuss the fundamental physical principles of STT-MRAM operation, covering the range from device level to chip array performance, and methodology for its development.
Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder (2022)

Several large-scale whole-exome sequencing studies in patients with schizophrenia (SCZ) and autism spectrum disorder (ASD) have identified rare variants with modest or strong effect size as genetic risk factors. Dysregulation of cellular calcium homeostasis might be involved in SCZ/ASD pathogenesis, and genes encoding L-type voltage-gated calcium channel (VGCC) subunits Ca<sub>v</sub>1.1 (CACNA1S), Ca<sub>v</sub>1.2 (CACNA1C), Ca<sub>v</sub>1.3 (CACNA1D), and T-type VGCC subunit Ca<sub>v</sub>3.3 (CACNA1I) recently were identified as risk loci for psychiatric disorders. We performed a screening study, using the Ion Torrent Personal Genome Machine (PGM), of exon regions of these four candidate genes (CACNA1C, CACNA1D, CACNA1S, CACNA1I) in 370 Japanese patients with SCZ and 192 with ASD. Variant filtering was applied to identify biologically relevant mutations that were not registered in the dbSNP database or that have a minor allele frequency of less than 1% in East-Asian samples from databases; and are potentially disruptive, including nonsense, frameshift, canonical splicing site single nucleotide variants (SNVs), and non-synonymous SNVs predicted as damaging by five different in silico analyses. Each of these filtered mutations were confirmed by Sanger sequencing. If parental samples were available, segregation analysis was employed for measuring the inheritance pattern. Using our filter, we discovered one nonsense SNV (p.C1451* in CACNA1D), one de novo SNV (p.A36V in CACNA1C), one rare short deletion (p.E1675del in CACNA1D), and 14 NSstrict SNVs (non-synonymous SNV predicted as damaging by all of five in silico analyses). Neither p.A36V in CACNA1C nor p.C1451* in CACNA1D were found in 1871 SCZ cases, 380 ASD cases, or 1916 healthy controls in the independent sample set, suggesting that these SNVs might be ultra-rare SNVs in the Japanese population. The neuronal splicing isoform of Ca<sub>v</sub>1.2 with the p.A36V mutation, discovered in the present study, showed reduced Ca<sup>2+</sup>-dependent inhibition, resulting in excessive Ca<sup>2+</sup> entry through the mutant channel. These results suggested that this de novo SNV in CACNA1C might predispose to SCZ by affecting Ca<sup>2+</sup> homeostasis. Thus, our analysis successfully identified several ultra-rare and potentially disruptive gene variants, lending partial support to the hypothesis that VGCC-encoding genes may contribute to the risk of SCZ/ASD.
1-(3,4,5-Trimethoxyphenyl)naphthalene (2005)

The title compound, C19H18O3, is composed of a naphthalene ring, and a benzene ring with three substituents. The two H atoms on the benzene ring are enantiotopic; thus, one of them can be replaced with a bulky group to give an enantiomer of the resulting compound. The mean planes through the two ring systems are inclined to one another by 68.19 (10)°, with a central bridging bond of length 1.488 (3) Å.
Computer‐aided drug design of small molecule inhibitors of the ERCC1‐XPF protein–protein interaction (2019)

The heterodimer of DNA excision repair protein ERCC-1 and DNA repair endonuclease XPF (ERCC1-XPF) is a 5'-3' structure-specific endonuclease essential for the nucleotide excision repair (NER) pathway, and it is also involved in other DNA repair pathways. In cancer cells, ERCC1-XPF plays a central role in repairing DNA damage induced by chemotherapeutics including platinum-based and cross-linking agents; thus, its inhibition is a promising strategy to enhance the effect of these therapies. In this study, we rationally modified the structure of F06, a small molecule inhibitor of the ERCC1-XPF interaction (Molecular Pharmacology, 84, 2013 and 12), to improve its binding to the target. We followed a multi-step computational approach to investigate potential modification sites of F06, rationally design and rank a library of analogues, and identify candidates for chemical synthesis and in vitro testing. Our top compound, B5, showed an improved half-maximum inhibitory concentration (IC<sub>50</sub> ) value of 0.49 µM for the inhibition of ERCC1-XPF endonuclease activit, and lays the foundation for further testing and optimization. Also, the computational approach reported here can be used to develop DNA repair inhibitors targeting the ERCC1-XPF complex.
Enhanced dielectric properties of (Ba,Sr)TiO3//Ba(Zr,Ti)O3 heterostructures with optimized structure design (2013)

Environment-friendly ferroelectric Mn:BST//Mn:BZT heterostructures were epitaxially deposited on (001) MgO substrates by pulsed laser deposition with different combination ratios of Mn:BST over Mn:BZT, 2.5:7.5; 1:1; and 7.5:2.5. The microstructural studies indicate that the in-plane interface relationships between the heterostructures and the substrate are determined to be (001)Mn:BST//(001)Mn:BZT//(001)MgO and [100]Mn:BST//[100]Mn:BZT//[100]MgO. The Ku band microwave (15.5–18 GHz) dielectric property characterizations show that the dielectric constant, dielectric loss, and tunabilities of the heterostructures are highly dependent upon the sequences of Mn:BST to Mn:BZT. The optimized dielectric tunability with a low loss tangent was found to be 58.1%–74.4% under the combination ratio of 1:1 for Mn:BST to Mn:BZT, which suggests that the as-grown ferroelectric heterostructures can be developed for room temperature tunable microwave elements and related device applications.
Simultaneous cross-linking and p-doping of a polymeric semiconductor film by immersion into a phosphomolybdic acid solution for use in organic solar cells (2016)

Poly[N-9'-heptadecanyl-2,7-carbazole-alt-5,5-(4',7'-di-2-thienyl-2',1',3'-benzothiadiazole)] (PCDTBT) is shown to be simultaneously cross-linked and p-doped when immersed into a phosphomolybdic acid solution, yielding conductive films with low solubility that can withstand the solution processing of subsequent photoactive layers. Such a modified PCDTBT film serves to improve hole collection and limit carrier recombination in organic solar cells.
Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines (2016)

Blockage of more than one oncoprotein or pathway is now a standard approach in modern cancer therapy. Multiple inhibition is typically achieved with two or more drugs. Herein, we describe a pharmacophore merging strategy combining the JAK2/FLT3 inhibitor pacritnib with the pan-HDAC inhibitor, vorinostat, to create bispecific single molecules with both JAK and HDAC targeted inhibition. A preferred ether hydroxamate, 51, inhibits JAK2 and HDAC6 with low nanomolar potency, is <100 nM potent against HDACs 2 and 10, submicromolar potent against HDACs 1, 8, and 11, and >50-fold selective for JAK2 in a panel of 97 kinases. Broad cellular antiproliferative potency is supported by demonstration of JAK-STAT and HDAC pathway blockade in several hematological cell lines, inhibition of colony formation in HEL cells, and analysis of apoptosis. This study provides new tool compounds for further exploration of dual JAK-HDAC pathway inhibiton achieved with a single molecule.
Woman of Letters: A Life of Virginia Woolf by Phyllis Rose (1979)

Book Review| July 01 1979 Woman of Letters: A Life of Virginia Woolf by Phyllis Rose Woman of Letters: A Life of Virginia Woolf. By Rose, Phyllis. New York: Oxford University Press, 1978. Pp. xviii, 298. $12.95. Gary Davenport Gary Davenport Chapel Hill, N.C. Search for other works by this author on: This Site Google South Atlantic Quarterly (1979) 78 (3): 405–406. https://doi.org/10.1215/00382876-78-3-405 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn MailTo Permissions Search Site Citation Gary Davenport; Woman of Letters: A Life of Virginia Woolf by Phyllis Rose. South Atlantic Quarterly 1 July 1979; 78 (3): 405–406. doi: https://doi.org/10.1215/00382876-78-3-405 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsSouth Atlantic Quarterly Search Advanced Search The text of this article is only available as a PDF. Copyright © 1979 by Duke University Press1979 Article PDF first page preview Close Modal You do not currently have access to this content.
Enhanced synthesis method to prepare crystalline GaAs nanowires with high growth yield (2011)

Solid-source chemical vapor deposition method is developed for the synthesis of crystalline GaAs NWs with high growth yield using Ni thin film as catalysts on amorphous SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /Si substrates. The NW growth parameters are optimized at the source temperature of 900 °C, substrate temperature of 600 °C and H2 flow rate of 100 sccm for 30 min. The obtained NWs have a narrow distribution of diameters (21.0 ± 4.0 nm), with the length exceeding 10 μm. The NWs are grown along different crystallographic directions with low defect densities observed.
Generation of CD8+ T cell–mediated immunity against idiotype-negative lymphoma escapees (2009)

We investigated the ability of CpG-oligodeoxynucleotide to generate an anti-tumor CD8+ T-cell immune response and to synergize with passive antibody therapy. For these studies, we generated an antibody against the idiotype on the A20 B-cell lymphoma line. This antibody caused the regression of established tumors, but ultimately the tumors relapsed. The escaping surface IgG-negative tumor cells were resistant to both antibody-dependent cellular cytotoxicity and signaling-induced cell death. Addition of intratumoral CpG to antibody therapy cured large established tumors and prevented the occurrence of tumor escapees. The failure of the combination therapy in mice deficient for CD8+ T cells demonstrates the critical role of CD8+ T cells in tumor eradication. When mice were inoculated with 2 tumors and treated systemically with antibody followed by intratumoral CpG in just one tumor, both tumors regressed, indicating that a systemic immune response was generated. Although antibody therapy can eliminate tumor cells bearing the target antigen, it frequently selects for antigen loss variants. However, when a poly-specific T-cell response was generated against the tumor by intratumoral CpG, even large established tumors were cured. Such an immune response can prevent the emergence of antibody selected tumor escapees and provide long-lasting tumor protection.
Motion compensated frame rate conversion using motion scaling (2015)

This paper proposes an efficient motion compensated frame rate conversion method using scaled motion. Different from previous methods where motion estimation and motion compensated interpolation having same search range, proposed method reduces the search range of motion compensated interpolation while search range of motion estimation remains unchanged. Experimental results show that the proposed method achieves internal memory reduction for storing pixels within search range of motion compensation without significant quality degradation.
Diele ctric Resonators for High Q, Dual-Mode, Mobile Communications Filters (2001)

A new suspended and grooved dielectric resonator configuration is used for realizing high unloaded Q-factor, wide spurious-free operating window and tight coupling either to input or between dual-mode resonances. The latter couplings are obtained by inserting probes inside the dielectric resonator groove. This approach allows significant values of coupling /tuning to be obtained while metallic contacts with the dielectric resonator are avoided. Experimental results, on a three-pole filter with an asymmetric transmission zero, confirm the validity of the proposed resonator for realizing transmit filters for UMTS cellular-radio base stations.
Measurement of theBs0→μ+μ−Branching Fraction and Search forB0→μ+μ−with the CMS Experiment (2013)

Results are presented from a search for the rare decays Bs(0)→μ+ μ- and B(0)→μ+ μ- in pp collisions at sqrt[s]=7 and 8 TeV, with data samples corresponding to integrated luminosities of 5 and 20 fb(-1), respectively, collected by the CMS experiment at the LHC. An unbinned maximum-likelihood fit to the dimuon invariant mass distribution gives a branching fraction B(Bs(0)→μ+ μ-)=(3.0(-0.9)(+1.0))×10(-9), where the uncertainty includes both statistical and systematic contributions. An excess of Bs(0)→μ+ μ- events with respect to background is observed with a significance of 4.3 standard deviations. For the decay B(0)→μ+ μ- an upper limit of B(B(0)→μ+ μ-)<1.1×10(-9) at the 95% confidence level is determined. Both results are in agreement with the expectations from the standard model.
ion Time Tasks in Distribu (1996)

Task-execution times are one of the most important parameters in scheduling tasks. Most scheduling algorithms are based on the assumption that either worst-case task-execution times are known to the scheduler or no information on execution times is available at all. While scheduling tasks based on worst-case execution times can guarantee to meet their timing requirements, it may lead to severe under-utilization of CPUs because worst-case execution times could be one or two orders of magnitude larger than the corresponding actual values. Scheduling tasks based on the execution time distribution (instead of worst- case execution timvs) is known to improve system utilization significantly. In this paper, wb propose a model to predict task execution times in a distributed system. The model considers several factors which affect the execution time of each task. These factors are classified into two groups: intrinsic and extrinsic. The intrinsic factors control the flow within a task, while the extrinsic factors include communication and synchronization delays between tasks. By simplifying the extrinsic factors, we represent a distributed system with a simple queuing model. The proposed queuing model consists of two stations: one for computation and the other for communication and synchronization. Information on system utilization can be obtained by converting this queuing model to a Markov chain. The execution time of a task is then derived from the information on system utilization in the form of average and distribution. The model is extended to describe the effects of multiple tasks assigned to a single processing node. The utility of the model is demonstrated with an example.
Benchmarking state-of-the-art optical simulation methods for analyzing large nanophotonic structures (2018)

Five computational methods are benchmarked by computing quality factors and resonance wavelengths inphotonic crystal membrane L5 and L9 line defect cavities. Careful convergence studies reveal that some methods are more suitable than others for analyzing these cavities.
Molecular Detection of Bone Marrow (BM) Involvement in Primary Cutaneous B Cell Non Hodgkin’s Lymphoma (NHL) at Diagnosis. (2004)

Abstract Although the skin is the second most common site of involvement for extranodal lymphomas, only 20% of cutaneous NHL are of B cell origin. A wide range of B cell lymphomas can occur as primary cutaneous tumors and their clinical course can not always be predicted by histology alone. The incidence and significance of the presence of clonal B cell populations in the BM of affected patients at the time of diagnosis are presently unknown. On another hand, the BIOMED II primers were shown to have a high sensitivity for the detection of clonality in B cell lymphoproliferative disorders. We sought to determine the incidence of occult BM involvement in a series of twelve patients (3 women and 9 men, median age 54.5, 28 to 77 years old) diagnosed with primary cutaneous B cell lymphoma between August 2000 and May 2004, for whom skin biopsies, BM trephine biopsies and aspirates and clinical data were available for review. For that, we investigated the presence of clonal B cell populations in the BM aspirates obtained as part of the initial staging procedures by PCR (employing heteroduplex and GeneScanning analysis), using the BIOMED II primers for the immunoglobulin k light chain (IGK) and the immunoglobulin heavy chain complete and incomplete (IGH) rearrangements. At the same time, a set of amplified gene fragments of known sizes was run as a control of the DNA integrity. Patients’ diagnoses, according to the WHO classification, were marginal zone B cell lymphoma (5 cases), diffuse large B cell lymphoma (5 cases), follicular lymphoma (1 case) and NHL NOS (1 case). In all cases clinical evaluation, CT scans from the thorax, abdomen and pelvis as well as BM trephine biopsies failed to demonstrate extracutaneous involvement by NHL. Moreover, a maximum of 6% of policlonal CD19+ B cells were present in the BM aspirates as evaluated by flow cytometry. In three out of 12 cases (25%) a B cell clonal population was present in the BM, as demonstrated by the presence of an IGH clonal rearrangement detected by heteroduplex and/or GeneScanning analysis; they corresponded to two diffuse large B cell NHL cases and one marginal zone B cell lymphoma. Two of these patients are still under treatment and one (with diffuse large B cell lymphoma) remains in complete remission 9 months after first line therapy. In this small series of patients the detection of clonal B cell rearrangements in the BM analyzed at the time of diagnosis was uncommon; the clinical course of the positive cases did not differ from the whole series. Further follow-up studies are needed to define the significance and prognostic impact of those BM clones in cutaneous B cell NHL patients.
ChemInform Abstract: 5‐HT1A and 5‐HT2A Ligands with Anxiolytic and Antipanic‐Like Properties. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The hip in adults with classic bladder exstrophy: a biomechanical analysis. (2000)

We studied the untreated pelvic deformity in 14 adult patients with bladder exstrophy to determine the relative hip-joint force and stress and their effects on the clinical status of the hip. Pelvic radiographs were used for biomechanical analysis to calculate joint force and joint stress (force/area) relative to partial body weight, which allowed comparison between patients and age-matched controls. IOWA hip ratings were used for clinical evaluation, and hips were scored radiographically for degenerative joint disease. The mean relative joint force and joint stress was significantly higher for exstrophy patients (p < 0.001). In addition, the mean distance from the body center to the center of the femoral head was significantly increased (p < 0.001) in bladder exstrophy patients. An increase in diastasis correlated with an approximate 30% increase in the distance from the center of the femoral head to the body midline. The mean distance from the greater trochanter to the femoral head center was significantly less (p < 0.02) and the center-edge angle was significantly decreased in exstrophy patients (p < 0.05). Two patients' hips showed significant subluxation, and one of these showed degenerative hip disease in association with poor IOWA and radiographic scores. The force and stress on the hip joint are increased in untreated adult bladder exstrophy patients. Further longitudinal study is indicated to validate these findings and to determine whether clinically important degenerative changes are occurring. This could affect treatment recommendations in childhood.
In Vivo Neutralization of Human IL-6 (hIL-6) Achieved by Immunization of hIL-6-Transgenic Mice with a hIL-6 Receptor Antagonist (2001)

Abstract Neutralization of IL-6 represents an attractive therapeutic option in several diseases, including B cell neoplasia, osteoporosis, and autoimmunity. Therapeutic attempts in humans have shown that administration of injectable doses of a mAb to IL-6 does not provide efficient neutralization of the cytokine in vivo. Therefore, alternative approaches are needed. In this study, we evaluated whether the Ab response to human IL-6 (hIL-6) elicited by vaccination with Sant1 (a hIL-6 variant with seven amino acid substitutions) was able to fully correct in vivo the clinical and biological effects of a chronic endogenous overproduction of hIL-6 in the hIL-6-transgenic NSE/hIL-6 mice. Because of the overexpression of hIL-6, occurring since birth, with circulating levels in the nanogram per milliliter range, NSE/hIL-6 mice have a marked decrease in growth rate, associated with decrease in insulin-like growth factor I levels, and represent an animal model of the growth impairment associated with human chronic inflammatory diseases. Following immunization with Sant1, but not with hIL-6, NSE/hIL-6 mice developed high titers of polyclonal Abs to hIL-6. The Abs, acquired by transplacental transfer, effectively neutralized IL-6 activities in vivo as shown by the complete correction of the growth defect and normalization of insulin-like growth factor levels in the hIL-6-transgenic offspring. Immunization with Sant1 could therefore represent a novel and simple therapeutic approach for the specific neutralization of IL-6 in humans.
Methyl Formate Formation from Methanol Oxidation Using Supported Gold–Palladium Nanoparticles (2014)

Recent advances in the oxidation of alcohols to methyl esters using metal nanoparticles have paved the way for more environmentally benign processes, operating at lower reaction temperatures with high product selectivity. Here, we demonstrate the use of bimetallic 1 wt % Au-Pd/TiO2 catalysts that achieve high activity for the oxidation of methanol to methyl formate at low temperature. The application of a water extraction treatment to retain size-stabilized Au-Pd nanoparticles, in contrast to a more standard thermal treatment, provides the most active catalyst for this reaction. Using in situ DRIFTS, we demonstrate that in situ activation during methanol oxidation enhances the catalytic activity at low temperature and that this is a long-lived effect. Surface adsorbates, particularly formate species, build up on the catalyst surface during the reaction and are proven vital to enhancing the catalytic effect. (Chemical Equation Presented).