gebhart/patrepeval huggingface dataset:
Abstract 612: Identification of selective inhibitors of diffuse-type gastric cancer cells by screening of annotated compounds (2016)

Abstract Diffuse-type gastric cancer (DGC) exhibits rapid disease progression and a poor prognosis. We have reported an E-cadherin/p53 double conditional knockout (DCKO) mouse line as the first genetically engineered one, which morphologically and molecularly recapitulates human DGC. We have also established mouse gastric cancer (GC) cell lines from DGC of the DCKO mice, demonstrating strong resistance to cytotoxic anti-cancer agents and high tumorigenic property when subcutaneously injected to nude mice. Then, we performed a synthetic lethal screening of 1535 annotated chemical compounds, and identified 27 candidates with selective inhibitory activity against the GC cell lines. These candidate drugs were classified into some classes, and members of the most potent class specifically attenuated cell proliferation of the GC cell lines by induction of apoptosis as well as suppressing tumor growth in vivo. Expectedly, E-cadherin-mutant and -low human gastric cancer cell lines were more sensitive to them in contrast to E-cadherin-intact ones. These findings may lead to development of novel drugs and discovery of potential targets in human DGC. Citation Format: Shu Shimada, Yoshimitsu Akiyama, Hiroshi Fukamachi, Yasuhito Yuasa, Shinji Tanaka. Identification of selective inhibitors of diffuse-type gastric cancer cells by screening of annotated compounds. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 612.
Stent healing response following delivery of paclitaxel via durable polymeric matrix versus iopromide-based balloon coating in the familial hypercholesterolaemic swine model of coronary injury (2013)

In the FHS coronary injury model, BMS implantation using a PCB yields a degree of neointimal inhibition comparable to the PES. The BMS+PCB combination presented lower degrees of inflammation and fibrin deposition; however, signs of delayed healing were still present.
Structure of bis(cyclopentadienyl)methylmethylenetantalum and the estimated barrier to rotation about the tantalum-methylene bond (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure of bis(cyclopentadienyl)methylmethylenetantalum and the estimated barrier to rotation about the tantalum-methylene bondL. J. Guggenberger and R. R. SchrockCite this: J. Am. Chem. Soc. 1975, 97, 22, 6578–6579Publication Date (Print):October 1, 1975Publication History Published online1 May 2002Published inissue 1 October 1975https://pubs.acs.org/doi/10.1021/ja00855a049https://doi.org/10.1021/ja00855a049research-articleACS PublicationsRequest reuse permissionsArticle Views677Altmetric-Citations89LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An empirical study of a wide-area distributed file system (1996)

The evolution of the Andrew File System (AFS) into a wide-area distributed file system has encouraged collaboration and information dissemination on a much broader scale than ever before. We examine AFS as a provider of wide-area file services to over 100 organizations around the world. We discuss usage characteristics of AFS derived from empirical measurements of the system. Our observations indicate that AFS provides robust and efficient data access in its current configuration, thus confirming its viability as a design point for wide-area distributed file systems.
VLSI Architectures for Discrete Wavelet Transforms (2004)

In this chapter, we have presented VLSI algorithms and architectures for Discrete Wavelet Transforms. We described the traditional convolution (filtering) approach for computation of discrete wavelet transform and described how a systolic architecture can be designed for wavelet filters by exploiting the symmetric relationship of the filter coefficients. Since the lifting-based wavelet transform is a development in late 90's and new in the VLSI community, we have emphasized more on the VLSI architectures for the lifting based DWT computation in this chapter. Lifting based DWT has many advantages over the traditional convolution based approach. It requires less memory and computation for implementation compared to the convolution approach. We have reviewed and presented the VLSI architectures that have been reported very recently for lifting-based DWT. We have presented how data-dependency diagram for the lifting computation can be mapped into pipelined architectures for suitable VLSI implementation and proposed enhancement of the pipeline architectures by applying different schemes reported in the literature. We described in greater detail a highly folded VLSI architecture for computation of both one-dimensional and two-dimensional transformations.
Noisy Cryptographic Protocols for Low-Cost RFID Tags (2006)

Considering some passive eavesdropper, the feasibility of exchanging some secret data between an RFID tag and its reader through public discussion is established. No key distribution is required by our solution; the tag and the reader do not have to share any common data to form a confidential channel. For this, a natural phenomenon—the inherent noise on their communication link—is exploited. Classical protocols, consisting after an initialization step in three phases called advantage distillation, information reconciliation and privacy amplification, are then adapted to these highly constrained devices. First, the canvas of our study is presented. Next, the advantage distillation phase is discussed. Then, Brassard and Salvail's Cascade protocol is proved to be modifiable so as to reduce the hardware implementation cost while still maintaining adequate correction rate and tolerable leaked information during the reconciliation phase. Finally, as for the privacy amplification phase, the work on low-cost universal hash functions from YÜksel is pointed out, achieving to allege that public discussion under noisy environment might be an interesting possibility for low cost RFID tags.
EFFECTS OF α 1 -ADRENERGIC RECEPTOR SUBTYPE SELECTIVE ANTAGONISTS ON LOWER URINARY TRACT FUNCTION IN RATS WITH BLADDER OUTLET OBSTRUCTION (2004)

Urinary frequency is increased in rats with a bladder mass of greater than 500 mg. The combined alpha 1a/alpha 1dAR antagonist tamsulosin decreases urinary frequency more than the alpha 1aAR selective antagonist 5MU. This finding supports the hypothesis that the alpha 1dAR is important for mediating irritative symptoms.
Cumulative Gaussian Curve Fitter for Boundary Parameterization (2005)

We have previously developed an algorithm for locating boundaries in an image with sub-pixel resolution, as well as estimating boundary width and image intensity within the adjoining objects. The algorithm operates by finding the parameters of a cumulative Gaussian curve that best approximates an intensity profile taken across a boundary. If intensity is sampled along the image gradient across a boundary, it is reasonable to assume the profile approximates a finite portion of a cumulative Gaussian. Given that assumption, the first derivative of the profile should be the corresponding portion of a Gaussian, completely described by its mean, standard deviation, and amplitude. We present here a simple and rapid method to find those parameters, given that we only have a potentially skewed sample of the Gaussian. The parameters are approximated first for the finite sample, and then both ends of the Gaussian are extrapolated using the resulting parameters. New parameters are then calculated and the procedure is repeated. The optimization rapidly converges, yielding boundary location (mean) with sub-pixel accuracy as well boundary width (standard deviation). Integration then reproduces the cumulative Gaussian, and a least-squares fit is applied to estimate the constant of integration, from which intensity of the adjoining regions can be estimated.
Somatic and germinal activities of maize Activator (Ac) transposase mutants in transgenic tobacco (1995)

The properties have been investigated of two deletion derivatives of the transposase protein (TPase) of maize transposable element Ac in transgenic tobacco. The wild‐type and mutant TPases were expressed as fusions to the cauliflower mosaic virus 35S promoter. A deletion of 102 amino acids from the N‐terminus, TPase(103–807), induces Ds excisions from a SPT::Ds reporter locus with a higher frequency than the wild‐type TPase. The increased transpositional activity of TPase(103–807) is a dominant trait, as seedlings coexpressing truncated and wild‐type TPase show the characteristic TPase(103–807) variegation pheno‐type. A transpositionally inactive TPase deletion derivative lacking 188 amino acids from the N‐terminus inhibits the transpositional activity of the wild‐type TPase.
Using full reference history for efficient document replacement in web caches (1999)

With the increase in popularity of the World Wide Web, the research community has recently seen a proliferation of Web caching algorithms. This paper presents a new such algorithm, that is efficient and robust, called Least Unified-Value (LUV). LUV evaluates a Web document based on its cost normalized by the likelihood of it being re-referenced. This results in a normalized assessment of the contribution to the value of a document, leading to a fair replacement policy. LUV can conform to arbitrary cost functions of Web documents, so it can optimize any particular performance measure of interest, such as the hit rate, the byte hit rate, or the delay-savings ratio. Unlike most existing algorithms, LUV exploits complete reference history of documents, in terms of reference frequency and recency, to estimate the likelihood of being re-referenced. Nevertheless, LUV allows for an efficient implementation in both space and time complexities. The space needed to maintain the reference history of a document is only a few bytes and furthermore, the time complexity of the algorithm is O(log2n), where n is the number of documents in the cache. Trace-driven simulations show that the LUV algorithm outperforms existing algorithms for various performance measures for a wide range of cache configurations.
Crosstalk analysis applied to wavelength selective switches (2006)

We show that the tolerance to in-band crosstalk due to a slight misalignment of the filtering function can be relaxed. Such impairment may occur in case of WSS requiring accurate alignments of several optical elements
Effect of Post Growth Annealing on the Structural and Electrical Properties of ZnO/CuO Composite Nanostructures (2014)

In the present work, ZnO/CuO composite nanostructures have been grown on uorine doped tin oxide coated glass substrate by aqueous chemical growth method. To observe the eect of post growth annealing (500 C, 1 min) on the structural properties of ZnO nanorods scanning electron microscope and X-ray diraction techniques have been utilized. SEM images of post growth annealed (post growth annealed) sample reveal that the average diameter of ZnO NRs has considerably increased in comparison with as grown sample. Moreover after post growth annealing the ZnO NRs showed more clearly hexagonal wurtzite structure. Beside this the NRs are also uniform and well aligned with a high aspect ratio of 10. In XRD pattern the strongly intense (002) peak of the post growth annealing sample suggest that the crystal quality of the NRs have also been improved signicantly. Since the structural improvement have a signicant impact on charge transport properties as well, therefore the eect of post growth annealed has also been investigated by the electrical characterization of ZnO/CuO based heterojunction. The current-voltage measurements of the post growth annealed sample showed improvement in the current in comparison with as grown sample. The impedance study has also conrmed that the post growth annealed has inuence on the electrical properties. The presented post growth annealed heterojunction of ZnO/CuO may have space in applications like sensors and oxide based diodes in the devices fabrication.
A Sub-cm3 Energy-Harvesting Stacked Wireless Sensor Node Featuring a Near-Threshold Voltage IA-32 Microcontroller in 14-nm Tri-Gate CMOS for Always-ON Always-Sensing Applications (2017)

An energy-harvesting wireless sensor node (WSN) integrates a 14-nm, 0.79-mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , 32-b Intel Architecture corebased near-threshold voltage (NTV) microcontroller (MCU) that provides 17-μW/MHz always-ON, always-sensing (AOAS) capability. The MCU implements four independent voltage-frequency islands, managed by an integrated power management unit and features a subthreshold voltage capable on-die oscillator and 42-nm fin-pitch, 8.3-pA leakage-per-bit SRAM. The MCU operates across a wide frequency (voltage) range from 297 MHz (1 V) to 0.5 MHz (308 mV), dissipating 23.5 mW to 21 μW, and achieves 4.8× better energy efficiency at an optimum supply voltage (VOPT) of 370 mV, 3.5 MHz, and 17 pJ/cycle. A functional AOAS WSN incorporating the NTV MCU shows promise for sustained μW operation.
A fast robotic eye/head system: Eye design and performance (1992)

We describe here the initial stages in the design of a bin- ocular control system, to be mounted on a 3-D head controller. T his system is intended as a test-bed for the study of both robotic and biological gaze control. As in nature: (1) geometry relies on parallel actuators; (2) the visual sensor is mounted inside the eye to permit error-based control; (3) the intended use of an integrated (bilateral) control scheme to coordinate the trajectories of both eyes and the head. Results on the mechanical and sensory properties of the artificial eye are presented.
Reduction of Dispersion in Ultrasonically-Enhanced Micropacked Beds (2017)

Channeling of gas can reduce mass transfer performance in multiphase micropacked-bed reactors. Viscous and capillary forces cause this undesired and often unpredictable phenomenon in systems with catalyst particle sizes of hundreds of micrometers. In this work, we acoustically modify flow in a micropacked-bed reactor to reduce gas channeling by applying high-power sonication at low ultrasonic frequencies (∼40 kHz). Experimental residence time distributions reveal two orders of magnitude reduction in dispersion with ultrasound, allowing for nearly plug-flow behavior at high flow rates in the bed. Sonication appears to partially fluidize the packed-bed under pressurized cocurrent two-phase flow, effectively improving dispersion characteristics.
Development of biomarker genes for endocrine disruption assessment in the non-model crustacean species Gammarus fossarum (2016)

Despite the importance of invertebrates in aquatic systems, we lack specific biomarkers to assess the effects of endocrine disruption (ED) on these animals. This can be attributed to a poor knowledge of their endocrine systems and to the absence of genomic data for non-model species. The development of relevant tools for hazard assessment of ED is currently a challenge for crustacean species used in aquatic ecotoxicology. Our research teams have conducted a "proteogenomic" approach to generate a large transcriptomic and proteomic dataset for the amphipod crustacean Gammarus fossarum, a sentinel species used widely in aquatic ecotoxicology in Europe. However, among the 2257 MS-certified proteins obtained with this approach, key proteins involved in hormonal regulation that could be potential candidates for endocrine disruption biomarkers were not identified. Therefore, the aim of this study was to identify, in G. fossarum, some key players involved in the endocrine regulation of crustaceans/amphipods in order to propose candidate biomarkers of endocrine disruptions in this species. For this, we first established a list of candidate genes known to play an essential role in hormonal systems of crustaceans and insects: nuclear hormone receptors, other regulatory genes, enzymes of the hormone metabolism and hormone-regulated genes. Using sequence similarity and phylogenetic analyses, we identified similar sequences of three candidate genes in our transcriptomic G. fossarum database: the nuclear receptors RXR and E75, and the regulator broad-complex. The three genes were cloned in order to obtain reliable nucleotide sequences and primers for the subsequent expression studies. Their functional validation and relevance as biomarkers was then performed by studying gene expression during the female reproductive cycle, and after laboratory exposure to model ED chemical compounds (pyriproxyfen and tebufenozide).
Mild cognitive impairment and cognitive impairment, no dementia: Part B, therapy (2007)

Mild cognitive impairment (MCI) and cognitive impairment, no dementia (CIND) might be the optimum stage at which to intervene with preventative therapies. This article reviews recent work on the possible treatment and presents evidence-based recommendations approved at the meeting of the Third Consensus Conference on the Diagnosis and Treatment of Dementia held in Montreal in March, 2006. A number of promising nonpharmacologic interventions have been examined. Associations exist with both cognitive and physical activity that suggest that both of these, together or separately, can delay progression to dementia. Similarly, case control studies as well as prospective long-term studies suggest a number of low toxicity interventions and supplements that might significantly impact on MCI progression; folate, B(6), and B(12) to lower homocysteine levels, omega-fatty acids, and anti-oxidants (fruit juices or red wine) are good examples. In selected genotypes such as individuals with APOE e4, therapy with donepezil might slow progression. The concern, however, is that none of these therapies (including cholinesterase inhibitors) have demonstrated a clinically meaningful effect with randomized, placebo-controlled studies. Just as randomized controlled studies have failed to support primary prevention of dementia by using estrogen or nonsteroidal anti-inflammatory drugs (NSAIDs), there exists the possibility that well-designed randomized controlled trials might fail to definitively demonstrate putative or promising mild cognitive impairment interventions. Pharmacologic interventions and nonpharmacologic therapies, while tantalizing, are currently for the most part insufficiently proven to allow serious consideration by physicians. Recommendation were supported for a general "healthy lifestyle" including physical exercise, healthy nutrition, smoking cessation, and mental stimulation. Close monitoring and treatment of vascular risk factors are justified and were also supported.
High availability, elasticity, and strong consistency for massively parallel scans over relational data (2013)

An elastic and highly available data store is a key component of many cloud applications. Existing data stores with strong consistency guarantees are designed and optimized for small updates, key-value access, and (if supported) small range queries over a predefined key column. This raises performance and availability problems for applications which inherently require large updates, non-key access, and large range queries. This paper presents a solution to these problems: Crescando/RB; a distributed, scan-based, main memory, relational data store (single table) with robust performance and high availability. The system addresses a real, large-scale industry use case: the Amadeus travel management system. This paper focuses on the distribution layer of Crescando/RB, the problem and theory behind it, the rationale underlying key design decisions, and the novel multicast protocol and replication framework it is composed of. Highlighting the key features of the distribution layer, we present experimental results showing that even under permanent node failures and large-scale data repartitioning, Crescando/RB remains fully available and capable of sustaining a heavy query and update load.
A scalable systolic multiprocessor system for analysis of biological sequences (1993)

The design and implementation of an application-specific, faulttolerant, and scalable multiprocessor system called BioSCAN (Biological Sequence Comparative Analysis Node) are described. Discussed are system partitioning and integration, functional decomposition between hardware and software, the algorithm and its implementation in VLSI, the early results of using the system, and comparison with other hardware and software solutions for biological sequence analysis. 1. BIOLOGICAL SEQUENCE COMPARISON In the last decade, the field of molecular biology has seen a virtual explosion in the amount of data collected on a variety of living organisms. Much of this information identifies the primary structures of specific biopolymers of three classes: DNA + Correspondence: CB#3175, UNC-Chapel Hill, NC 27599-3175. E-mail: singh@cs.unc.edu (deoxyribonucleic acid), RNA (ribonucleic acid), and protein. Each class has its own distinct set of monomers. Members of the class are linear chains of monome...
Parallelized manipulation of adherent living cells by magnetic nanoparticles-mediated forces (2020)

Abstract The remote actuation of cellular processes such as migration or neuronal outgrowth is a challenge for future therapeutic applications in regenerative medicine. Among the different methods that have been proposed, the use of magnetic nanoparticles appears to be promising since magnetic fields can act at a distance without interactions with the surrounding biological system. To control biological processes at a subcellular spatial resolution, magnetic nanoparticles can be used either to induce biochemical reactions locally or to apply forces on different elements of the cell. Here, we show that cell migration and neurite outgrowth can be directed by the forces produced by a switchable parallelized array of micro-magnetic pillars, following passive uptake of nanoparticles. Using live cell imaging, we first demonstrate that adherent cell migration can be biased toward magnetic pillars and that cells can be reversibly trapped onto these pillars. Second, using differentiated neuronal cells we were able to induce events of neurite outgrowth in the direction of the pillars without impending cell viability. Our results show that the range of forces applied needs to be adapted precisely to the cellular process under consideration. We propose that cellular actuation is the result of the force on the plasma membrane caused by magnetically filled endo-compartments, which exert a pulling force on the cell periphery.
Adjuvant Concurrent Chemoradiation for Node-Positive Adenocarcinoma of the Duodenum (2007)

Adjuvant chemoradiation therapy after pancreaticoduodenectomy for node-positive duodenal adenocarcinoma may improve local control and median survival but does not impact 5-year overall survival.