gebhart/patrepeval huggingface dataset:
Photovoltaic differential power converter trade-offs as a consequence of panel variation (2012)

Photovoltaic (PV) elements have inherent variation between cells and panels due to manufacturing tolerance, degradation, and situational differences. This variation increases over system lifetime and creates maximum power point current mismatch that reduces output power when PV elements are strung in series. Traditionally, mismatch loss is addressed using cascaded converters. However, this research examines a differential converter architecture that achieves higher efficiency by processing a fraction of the total power. The effect of PV maximum power point (MPP) current variance on output power is modeled and examined using Monte Carlo simulation for the series string architecture with and without bypass diodes, and the PV-to-Bus and PV-to-PV differential power processing (DPP) architectures at various power ratings. Hot spotting can be a problem that significantly reduces output power. PV elements at fault can be bypassed, passively or actively, to reduce power loss. Simulation results show that both DPP architectures employing active bypass are able to compensate mismatch over the 25-year lifetime of a PV system with converters sized at approximately 10-20% of the panel ratings.
Characterization of the novel anti‐cancer therapeutic ONC201 and related analogs as non‐competitive antagonists of the D 2 dopamine receptor (2018)

ONC201 is the first member of a new class of anti‐cancer small molecules called imipridones to be investigated in clinical trials for select advanced cancers. The anti‐cancer properties of the parent compound were first discovered in a phenotypic screen as a p53‐independent inducer of the immune cytokine TRAIL and tumor cell death. Tumor cell signaling studies revealed that ONC201 causes a dual inactivation of Akt/ERK that drives Foxo3a‐mediated TRAIL gene induction. Recent studies identified that ONC201 also selectively antagonizes D2‐like dopamine receptors (D2R, D3R, D4R) at therapeutically relevant concentrations. Notably, malignant overexpression of the D2R occurs in a variety of cancers and its antagonism imparts pro‐apoptotic and anti‐proliferative effects in tumor cells. In the current study, we sought to characterize the pharmacological properties of ONC201 and several novel analogs (ONC206 and ONC213) on D2‐like receptors. Both functional signaling (β‐arrestin recruitment and cAMP accumulation) and radioligand competition binding assays were employed. Radioligand binding assays with [ 3 H]‐methylspiperone determined that these compounds bind to D2‐like receptors with low μM affinity, consistent with their potencies for anticancer activities. When the compounds were tested in β‐arrestin recruitment assays (D2R, D3R, and D4R) and cAMP accumulation assays (D2R and D4R), all analogs were determined to be antagonists with no measurable agonist efficacy. Importantly, a resolved enantiomer of ONC201 that showed no anti‐cancer activity was found to be inactive in blocking the D2R. To gain further insight into the mode of action of ONC201 and analogs at the D2R, Schild‐like curve shift assays were performed in using the functional assays, where increasing concentrations of compound are used to shift the dopamine concentration‐response curve. Increasing concentrations of all compounds caused both a rightward shift in the dopamine concentration‐response curve and a depression of the maximum response. These data are consistent with a non‐competitive mode of action and could be fitted with an operational model of allostery. These analyses revealed a predominant modulatory effect upon dopamine efficacy and a smaller effect on dopamine potency. Further studies will aim to elucidate the nature in which these analogs interact with D2R binding pockets through site‐directed mutagenesis. Understanding the pharmacological profile of ONC201, including different signaling paradigms, may lead to a better understanding of its mechanism for anticancer targeting. Support or Funding Information NINDS IRP This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
Thermal interaction between electronic components (1996)

The thermal performance of electronic components is generally quantified in terms of thermal resistances, which are used by system designers to calculate the operational junction temperature, and hence the expected Mean Time Between Failure. However, such thermal resistance data alone is of limited use to designers, and a need exists to increase awareness of the applicability of such results to practical situations. In this study the standard industrial practice of measuring a component`s forced-air junction-to-ambient thermal resistance was applied to both a single component mounted on the recommended test printed circuit board, and to components of the same type mounted in a regular array on a larger test board. Experimental results highlight the variation of component thermal resistance with air velocity, copper tracking distribution, component position on the test board, powered adjacent components, the presence of insulation on the non-component side and on an adjacent board, with the latter creating a channel flow. The most influential parameter was powered adjacent components, with reduced copper coverage and component positional changes on the multi-component board accounting for up to a 25% increase in thermal resistance when compared with the standard value. This approach represents a necessary first step towards the development ofmore » a more accurate design tool based on standard test methods.« less
Mechanically Activated MoO3. 2. Characterization of Defect Structures (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanically Activated MoO3. 2. Characterization of Defect StructuresG. Mestl, N. F. D. Verbruggen, and H. KnoezingerCite this: Langmuir 1995, 11, 8, 3035–3041Publication Date (Print):August 1, 1995Publication History Published online1 May 2002Published inissue 1 August 1995https://pubs.acs.org/doi/10.1021/la00008a031https://doi.org/10.1021/la00008a031research-articleACS PublicationsRequest reuse permissionsArticle Views667Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
CAR T-cell therapy is effective for CD19-dim B-lymphoblastic leukemia but is impacted by prior blinatumomab therapy (2019)

Tisagenlecleucel, a chimeric antigen receptor (CAR) T-cell product targeting CD19 is approved for relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). However, the impact of pretreatment variables, such as CD19 expression level, on leukemic blasts, the presence of CD19- subpopulations, and especially prior CD19-targeted therapy, on the response to CAR T-cell therapy has not been determined. We analyzed 166 patients treated with CAR T-cell therapy at our institution. Eleven patients did not achieve a minimal residual disease (MRD)- deep remission, whereas 67 patients had a recurrence after achieving a MRD- deep remission: 28 patients with CD19+ leukemia and 39 patients with CD19- leukemia. Return of CD19+ leukemia was associated with loss of CAR T-cell function, whereas CD19- leukemia was associated with continued CAR T-cell function. There were no significant differences in efficacy of CAR T cells in CD19-dim B-ALL, compared with CD19-normal or -bright B-ALL. Consistent with this, CAR T cells recognized and lysed cells with very low levels of CD19 expression in vitro. The presence of dim CD19 or rare CD19- events by flow cytometry did not predict nonresponse or recurrence after CAR T-cell therapy. However, prior therapy with the CD19-directed, bispecific T-cell engager blinatumomab was associated with a significantly higher rate of failure to achieve MRD- remission or subsequent loss of remission with antigen escape. Finally, immunophenotypic heterogeneity and lineage plasticity were independent of underlying clonotype and cytogenetic abnormalities.
”Encanto” - Let’s Talk About Bruno’s Visions (2022)

In Walt Disney Animation Studios’ ”Encanto”, Mirabel discovers the remnants of her Uncle Bruno’s mysterious visions of the future. Developing the look and lighting for the emerald shards required close collaboration between our Visual Development, Look Development, Lighting, and Technology departments to create a holographic effect. With an innovative new teleporting holographic shader, we were able to bring a unique and unusual effect to the screen.
Cost Effective Distributed Secondary Frequency Control: A Consensus + Innovations Approach (2014)

Distributed generation resources have become significantly more prevalent in the electric power system over the past few years. This warrants a reconsideration on how the coordination of generation resources is achieved. In this paper, we particularly focus on secondary frequency control. It is assumed that the system operator first selects the resources which are expected to provide secondary frequency control by carrying out a co-optimization between energy and ancillary service markets. Two kinds of payments are taken into account for the frequency control participants: the capacity payment and the performance payment. We first restructure the participants ’ cost functions to decouple these two payments. Then, we introduce a fully distributed real time control framework based on a consensus-plus-innovations approach, providing an alternative to the centralized automatic generation control approach. A key aspect is that the objective of the real time dispatch is to choose the most cost effective real-time deployment of the secondary frequency resources. We prove that our distributed control approach performs c-close to the centralized optimal economic dispatch, where c is a positive constant depending only on the cost parameters and the communication topology. Simulation results confirm the fast convergence and the cost effectiveness of the proposed distributed control approach.
Coherently Attached Programmable Near-Memory Acceleration Platform and its application to Stencil Processing (2019)

Application and technology trends are increasingly forcing computer systems to be designed for specific workloads and application domains. Although memory is one of the key components impacting the performance and power consumption of state-of-art computer systems, its operation typically cannot be adapted to workload characteristics beyond some limited controller configuration options. In this paper, we present a novel near-memory acceleration platform based on an Access Processor that enables the main memory system operation to be programmed and adapted dynamically to the accelerated workload. The platform targets both ASIC and FPGA implementations integrated within IBM POWER systems. We show how this platform can be applied to accelerate stencil processing.
Dissolution inhibition mechanisms of naphthoquinone diazides (1989)

Abstract Dissolution inhibition mechanisms of naphthoquinone diazides in novolak based positive photoresists were investigated from three different aspects: • Dipolar interaction. • Interfacial chemical reactions. • Chemical structures of naphthoquinone diazides. The results suggest that there exists a hydrogen bonding interaction between the compounds with the matrix novolak resin and that naphthoquinone diazides would crosslink the resin in contact with an alkaline developer, both of which contribute to dissolution inhibition mechanisms. However, there seems to exist another dissolution inhibition mechanism; namely, 1,2‐naphthoquinone diazide does not inhibit dissolution of the matrix novolak resin at all while a clear dissolution inhibition effect Is observed for its derivatives containing sulfonyl groups. In the present paper, three dissolution inhibition mechanisms of naphthoquinone diazides will be proposed.
Polynomial testing of packet switching networks (1989)

A functional testing method called polynomial testing is proposed to test packet-switching networks (PSNs) used in multiprocessor systems. Focus is on applying the method to packet-switching multistage interconnection networks (PMINs). A multiple stuck-at (MSA) fault model is developed and faults are diagnosed at two different levels: network level and switch level. The former uses each processor as a tester and can test part of the network concurrently with the normal operations on the remaining part of the network; the latter uses switches in the network as testers and is inherently an autonomous testing method. To facilitate the network-level testing, the routing dynamic in a PMIN is eliminated by synchronizing switch operations. The network is then decomposed into routes, each of which is tested after transforming it into a polynomial calculator. For switch-level testing, a built-in tester (BIT) is embedded into each switch's structure to provide self-testing capabilities. Network-level testing is distributed and suitable for concurrent testing, whereas switch-level testing is done offline, and needs only a small testing time.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Effects of N-H&lt;inf&gt;2&lt;/inf&gt;doses in ion-implanted bubble memory test chips (1982)

Recently 0.5Mbit 8μm period bubble memory chips based on ion-implanted propagation patterns were reported. In these devices, made with (YSmLuCa) <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> (FeGe) <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</inf> O <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</inf> 1.7μm bubble films, 270 keV neon implantation was done. In order to use a commercial implantation system, limited to 200 kV acceleration potential, we have tried 200 keV nitrogen for the medium depth implant in place of the 270 keV neon. We prepared devices with the 200/N and 130/H <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> doses increased proportionally in four steps over 2.7-4.0(10) <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">14</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> and 2.0- 3.0(10) <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">16</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> , respectively. We also used an unpatterned 80 keV neon implant of 1.0(10) <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">14</sup> cm-2 as was done previously. This paper reports measurements on these devices of (1) perpendicular strain by x-ray diffraction and easy plane anisotropy by FMR vs annealing temperature and (2) bias ranges for propagation vs annealing temperature, drive field, and operating temperature. Annealing lowered the magnitude of the anisotropy and strain of the implanted layer. At a critical anisotropy field H <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</inf> -4πM of about -1.5 kOe, major loop propagation failed. Although the margins change with annealing, the highest dosed devices continued to propagate after anneals of at least 375°C. Functionally complete circuits were processed at temperatures below 300°C and tested in wafer form at 50 kHz. With 40 Oe drive, the major loop and minor loops on test chips overlapped in bias by 24 Oe or better at 40°C for all four doses. At the temperature extremes of 0°C and 85°C, the overlap was ≥ 21 Oe.
The secrets of speed reading (1993)

Part of the One Hour Wordplay series of word guides, this book will help the reader's language skills without the need for a grammar book. Each of the titles in the series can be read in about one hour. This title will help the reader to use foreign words and phrases with confidence.
Synthesis and Biological Evaluation of Benzo[b]furans as Inhibitors of Tubulin Polymerization and Inducers of Apoptosis (2013)

A series of benzo[b]furans was synthesized with modification at the 5-position of the benzene ring by introducing C-linked substituents (aryl, alkenyl, alkynyl, etc.). These compounds were evaluated for their antiproliferative activities, inhibition of tubulin polymerization, and cell-cycle effects. Some compounds in this series displayed excellent activity in the nanomolar range against lung cancer (A549) and renal cell carcinoma (ACHN) cancer cell lines. (6-Methoxy-5-((4-methoxyphenyl)ethynyl)-3-methylbenzofuran-2-yl)(3,4,5-trimethoxyphenyl)methanone (26) and (E)-3-(6-methoxy-3-methyl-2-(1-(3,4,5-trimethoxyphenyl)vinyl)benzofuran-5-yl)prop-2-en-1-ol (36) showed significant activity in the A549 cell line, with IC₅₀ values of 0.08 and 0.06 μM, respectively. G₂/M cell-cycle arrest and subsequent apoptosis was observed in the A549 cell line after treatment with these compounds. The most active compound in this series, 36, also inhibited tubulin polymerization with a value similar to that of combretastatin A-4 (1.95 and 1.86 μM, respectively). Furthermore, detailed biological studies such as Hoechst 33258 staining, DNA fragmentation and caspase-3 assays, and western blot analyses with the pro-apoptotic protein Bax and the anti-apoptotic protein Bcl-2 also suggested that these compounds induce cell death by apoptosis. Molecular docking studies indicated that compound 36 interacts and binds efficiently with the tubulin protein.
Cycloreversion Approach For Preparation of Large π‐Conjugated Compounds (2014)

The strategy employing the cycloreversion reaction in the final step is a very powerful method for the preparation of highly conjugated compounds, which are so far unknown, difficult to access, intractable to purify, or impossible to measure. In this chapter, successful examples of such retro-Diels-Alder (rDA) approaches as well as the cheletropic cycloreversion are discussed by sorting the types of targeted large π-systems. Topics discussed include π-system expansion of porphyrinoids, π-expansion of porphyrazines and phthalocyanines, π-fusion of porphyrin oligomers, π-fusion of porphyrin and polycyclic aromatic hydrocarbons, π-expansion and fusion of boron-dipyrromethenes (BODIPYs), π-expansion of miscellaneous compounds based on bicyclo[2.2.2]octadiene (BCOD)-fused pyrroles, and π-system construction of acenes.
Tailoring Interfaces in Solid-State Batteries Using Interfacial Thermochemistry and Band Alignment (2021)

Solid-state lithium ion batteries have enhanced thermal stability compared to batteries using liquid electrolytes. Although their practical implementation is limited by undesired side reactions between the electrode and electrolyte, different modification strategies have been proposed to stabilize these reactive interfaces. These approaches have been primarily based upon bulk materials properties, however, which may not necessarily be representative of the chemistry at the solid/solid interface. Herein, first-principles calculations and X-ray scattering experiments are used to elucidate molecular-level reactivity and develop design principles for tailored interfaces based on surface and interfacial properties. Because of its well-known instability, the interface between the Li metal anode and the lithium lanthanum titanate (LLTO) solid electrolyte is applied as a model system. Density functional theory calculations are used to describe bulk, surface, and interfacial thermochemistry of the Li/LLTO system, and interfacial reconstruction is probed using ab initio molecular dynamics. These simulations of the Li/LLTO interface demonstrate facile decomposition concomitant with reduction of Ti4+ ions. Based on further insights from computational analysis of the surface band edge positions, La2O3 is proposed as an interlayer coating and is shown to provide an energetic barrier for interfacial charge transfer and decomposition reactions from X-ray reflectivity measurements and theoretical calculations. The findings in this work suggest that design strategies based on surface and interfacial properties can be used to kinetically stabilize electrode/electrolyte interfaces in solid-state batteries.
ChemInform Abstract: Synthesis and Evaluation of Water Soluble Indole Pyrrolothiazole PAF Antagonists. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Simple Virtual Aggregation (S-VA) (2012)

All BGP routers in the Default-Free Zone (DFZ) are required to carry
all routes in the Default-Free Routing Table (DFRT). This document
describes a technique, Simple Virtual Aggregation (S-VA), that allows
some BGP routers not to install all of those routes into the
Forwarding Information Base (FIB). Some routers in an Autonomous
System (AS) announce an aggregate (the VA prefix) in addition to the
routes they already announce. This enables other routers not to
install the routes covered by the VA prefix into the FIB as long as
those routes have the same next-hop as the VA prefix. The VA prefixes
that are announced within an AS are not announced to any other AS. The
described functionality is of very low operational complexity, as it
proposes a confined BGP speaker solution without any dependency on
network-wide configuration or requirement for any form of intra-domain
tunneling. This document is not an Internet Standards Track
specification; it is published for informational purposes.