gebhart/patrepeval huggingface dataset:
Immunological Characterization of Tristetraprolin as a Low Abundance, Inducible, Stable Cytosolic Protein (2004)

Tristetraprolin (TTP) is a zinc finger protein that can bind to AU-rich elements within certain mRNAs, resulting in deadenylation and destabilization of those mRNAs. Its physiological targets include the mRNAs encoding the cytokines tumor necrosis factor alpha (TNF) and granulocyte-macrophage colony-stimulating factor. TTP was originally identified on the basis of its massive but transient increase in mRNA levels following mitogen stimulation of fibroblasts. It has been difficult to reconcile this transient mRNA profile with the presumed continuing "need" for TTP protein, for example, to reverse the effects of lipopolysaccharide (LPS)-stimulated TNF secretion. To investigate this and other questions concerning endogenous TTP protein in cells and tissues, we raised a high titer rabbit antiserum against full-length mouse TTP. TTP could be detected on immunoblots of mouse cytosolic tissue extracts; it was most highly expressed in spleen, but its concentration in that tissue was only about 1.5 nm. TTP could be detected readily in splenic macrophages and stromal cells from LPS-injected rats. In both LPS-treated RAW 264.7 macrophages and fetal calf serum-treated mouse embryonic fibroblasts, TTP protein was stable after induction, with minimal degradation occurring for several hours after treatment of the cells with cycloheximide. The biosynthesis of TTP was accompanied by large changes in electrophoretic mobility consistent with progressive phosphorylation. Confocal microscopy revealed that TTP accumulated in a vesicular pattern in the cytosol of the LPS-stimulated RAW 264.7 cells, and was occasionally seen in the cytosol of unstimulated dividing cells. Gel filtration of the endogenous protein suggested that its predominant structure was monomeric. TTP appears to be a low abundance, cytosolic protein in unstimulated cells and tissues, but once induced is relatively stable, in contrast to its very labile mRNA.
Improved linearity, stability, and thermal performance of multi-mesa-channel AlGaN/GaN HEMTs (2018)

With its wide bandgap of 3.4 eV, gallium nitride (GaN) is considered as a key semiconductor material for realizing ultra-low-loss power devices. However, GaN-based devices is still plagued by current collapse, which is the temporary reduction of current after application of electrical stress. In this work, we present the state-of-art Multi-Mesa-Channel (MMC) AlGaN/GaN HEMT being developed in our laboratory. The MMC HEMT is fabricated in a way to realize parallel mesa-shaped nano-channels separated by trenches. Investigations have revealed that the MMC HEMT is highly resistant to current collapse and other instabilities, making it a leading power electronics prospect.
TL and PL in BaSr(SO4)2:Eu mixed sulphate (2006)

Abstract A highly sensitive thermoluminescent (TL) phosphor based on BaSr(SO 4 ) 2 :Eu has been developed. The phosphor was recrystallized from H 2 SO 4 solution by evaporation. Photoluminescence studies of this mixed‐sulphate phosphor show that Eu is incorporated in the host in its divalent (emission at 383 nm) as well as trivalent (emissions at 575 and 731 nm) form due to 4f 6 5d → 8 S 7/2 and 5 D 0 → 7 F j transitions, respectively. The intensity of the 383 nm band increases with increasing irradiation, while that of the 731 nm band decreases, showing Eu 3+ → Eu 2+ conversion. The TL glow curve of the BaSr(SO 4 ) 2 :Eu material shows a single peak at 470 K along with a small shoulder at around 428 K. The relative intensities of these peaks are found to vary with γ‐ray exposure. The TL sensitivity of the mixed‐sulphate phosphor is nearly 2.5, 7 and 1.2 times higher than those of BaSO 4 :Eu, SrSO 4 :Eu and CaSO 4 :Dy phosphors, respectively. The annealing temperature and the impurity concentration effects are also studied. (© 2006 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Mechanism of Nicotinamide Riboside as an Aid to Weight Loss (2015)

Caged mice represent an attractive model system with which to dissect the mechanistic basis for dietary and activity interventions because one can control for food amounts, dietary compositions, supplementation, and exercise in addition to genotype. Here we report that oral nicotinamide riboside (NR) supplementation increases weight loss with respect to nonsupplemented C57BL/6 mice. NR‐dependent weight loss was much more effective than resistance to weight gain on high fat diet (HFD), which has been previously reported. To assess weight loss, mice were first fattened on HFD and then assigned to normal chow plus or minus NR. Supplemented and nonsupplemented mice were also randomized to 5 days/week forced exercise or not. NR and exercise promoted weight loss individually and in an additive fashion. To assess the mechanism by which NR promotes weight loss, we measured calorie intake, activity, calorie waisted, resting metabolic rate, body composition, glucose tolerance, insulin sensitivity, and a variety of biochemical and metabolomic parameters related to liver mitochondrial function. The data are consistent with a novel malabsorptive mechanism for weight loss that can be tracked by excreted biomarkers. NR analogs and proteomic analysis of mitochondrial post‐translational modifications are being used to further characterize the mechanistic basis for NR activity in weight loss.
Prognostic Significance of Interferon-γ and Its Signaling Pathway in Early Breast Cancer Depends on the Molecular Subtypes (2020)

Interferons are crucial for adaptive immunity and play an important role in the immune landscape of breast cancer. Using microarray-based gene expression analysis, we examined the subtype-specific prognostic significance of interferon-γ (IFN-γ) as a single gene as well as an IFN-γ signature covering the signaling pathway in 461 breast cancer patients. Prognostic significance of IFN-γ, as well as the IFN-γ signature for metastasis-free survival (MFS), were examined using Kaplan-Meier as well as univariate and multivariate Cox regression analyses in the whole cohort and in different molecular subtypes. The independent prognostic significance of IFN-γ as a single gene was limited to basal-like breast cancer (hazard ratio (HR) 2.779, 95% confidence interval (95% CI) 1.117-6.919, <i>p</i> = 0.028). In contrast, the IFN-γ-associated gene signature was an independent prognostic factor in the whole cohort (HR 2.287, 95% CI 1.410-3.633, <i>p</i> < 0.001) as well as in the basal-like (HR 3.458, 95% CI 1.154-10.359, <i>p</i> = 0.027) and luminal B (HR 2.690, 95% CI 1.416-5.112, <i>p</i> = 0.003) molecular subtypes. These results underline the subtype-dependent prognostic influence of the immune system in early breast cancer.
Thermal photovoltaic cells (1995)

Most current emphasis is on GaInAs alloys or GaSb for thermal photovoltaic converters operating in a band gap range between about 0.50 to 0.75 eV. In this paper the growth and fabrication of GaInAs devices with nominal band gaps of 0.6 eV are described. Yield statistics are presented for the growth of a large number of devices, and I‐V data are presented. Alternative cell structures are also described, and manufacturing issues are discussed.
Large-scale analysis of SARS-CoV-2 spike-glycoprotein mutants demonstrates the need for continuous screening of virus isolates (2021)

Abstract Due to the widespread of the COVID-19 pandemic, the SARS-CoV-2 genome is evolving in diverse human populations. Several studies already reported different strains and an increase in the mutation rate. Particularly, mutations in SARS-CoV-2 spike-glycoprotein are of great interest as it mediates infection in human and recently approved mRNA vaccines are designed to induce immune responses against it. We analyzed 146,917 SARS-CoV-2 genome assemblies and 2,393 NGS datasets from GISAID, NCBI Virus and NCBI SRA archives focusing on non-synonymous mutations in the spike protein. Only around 13.8% of the samples contained the wild-type spike protein with no variation from the reference. Among the spike protein mutants, we confirmed a low mutation rate exhibiting less than 10 non-synonymous mutations in 99.98% of the analyzed sequences, but the mean and median number of spike protein mutations per sample increased over time. 2,592 distinct variants were found in total. The majority of the observed variants were recurrent, but only nine and 23 recurrent variants were found in at least 0.5% of the mutant genome assemblies and NGS samples, respectively. Further, we found high-confidence subclonal variants in about 15.1% of the NGS data sets with mutant spike protein, which might indicate co-infection with various SARS-CoV-2 strains and/or intra-host evolution. Lastly, some variants might have an effect on antibody binding or T-cell recognition. These findings demonstrate the increasing importance of monitoring SARS-CoV-2 sequences for an early detection of variants that require adaptations in preventive and therapeutic strategies.
Quantify antibody secreting cells (ASC) by ELISPOT in fish (1993)

International audience
Over-expression of eNOS led to increased levels of nitrosylated proteins in the mouse livers. (2015)

&lt;p&gt;Two bands (−25 kD and 50 kD) of nitrosylated protein were detected by Western blot analysis of hepatic total proteins.&lt;/p&gt;
Numerical Analysis of Si-based Photovoltaic Modules with Different Interconnection Methods (2014)

This paper investigates the output powers of PV modules by predicting three unknown parameters: reverse saturation current, and series and shunt resistances. A theoretical model using the non-uniform physical parameters of solar cells, including the temperature coefficients, voltage, current, series and shunt resistances, is proposed to obtain the I-V characteristics of PV modules. The solar irradiation effect is included in the model to improve the accuracy of the output power. Analytical and Newton methods are implemented in MATLAB to calculate a module output. Experimental data of the non-uniform solar cells for both serial and parallel connections are used to extend the implementation of the model based on the I-V equation of the equivalent circuit of the cells and to extend the application of the model to m by n modules configuration. Moreover, the theoretical model incorporates, for the first time, the variations of series and shunt resistances, reverse saturation current and irradiation for easy implementation in real power generation. Finally, this model can be useful in predicting the degradation of a PV system because of evaluating the variations of series and shunt resistances, which are critical in the reliability analysis of PV power generation.
Distortion-Resilient Routing for Video Flows in Wireless Multi-hop Networks (2012)

Traditional routing metrics designed for wireless networks are application agnostic. In this paper, we consider a wireless network where the application flows consist of video traffic. From a user-perspective, reducing the level of video distortion is critical. We ask the question “Should the routing policies change if the end-to-end video distortion is to be minimized?” Popular link-quality based routing metrics (such as ETX) do not account for dependence (in terms of congestion) across the links of a path; as a result, they can cause video flows to converge onto a few paths and thus, cause high video distortion. To account for the evolution of the video frame loss process we construct an analytical framework to first, understand and second, assess the impact of the wireless network on video distortion. The framework allows us to formulate a routing policy for minimizing distortion, based on which we design a protocol for routing video traffic. We find via simulations and testbed experiments that our protocol is efficient in reducing video distortion and minimizing the user experience degradation. Specifically, our protocol reduces the distortion by 20% over traditional methods, which significantly improves the video quality perceived by a user.
Resonance Fluorescence from a Coherently Driven Semiconductor Quantum Dot in a Cavity (2007)

We show that resonance fluorescence, i.e., the resonant emission of a coherently driven two-level system, can be realized with a semiconductor quantum dot. The dot is embedded in a planar optical microcavity and excited in a waveguide mode so as to discriminate its emission from residual laser scattering. The transition from the weak to the strong excitation regime is characterized by the emergence of oscillations in the first-order correlation function of the fluorescence, g(tau), as measured by interferometry. The measurements correspond to a Mollow triplet with a Rabi splitting of up to 13.3 microeV. Second-order correlation measurements further confirm nonclassical light emission.
When Things Are Not as They Seem: Quantum Interference Turns Molecular Electron Transfer “Rules” Upside Down (2008)

We present an interesting consequence of the differences between cross-conjugated and linearly conjugated molecules: the breakdown of conventional understanding of trends in molecular electron transfer. Interference effects are dominant in cross-conjugated molecules with unusual results: long molecules may have faster rates of electron transfer than short molecules, saturated molecules may have faster rates of electron transfer than conjugated molecules of the same length, and the rate of electron transfer cannot be correlated with energy gaps between the donor and acceptor states and the energy levels of the bridging molecule.
Overview of QoS options for HSDPA (2006)

The functional split between the centralized radio network controller and the base station (Node-B) presents new challenges and opportunities for implementing QoS control for HSDPA. In this article we present different options for implementing QoS over HSDPA ranging from quality-based HSDPA access control algorithms to QoS-aware Node-B packet schedulers. The article concludes with network performance results for different services over HSDPA.
Bioelectronic Detection Schemes for Biomedical and Environmental Sensing (2008)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Microphone Array Beamforming With High Flexible Interference Attenuation and Noise Reduction (2022)

This paper studies the problem of microphone array beamforming to enhance a speech signal of interest in adverse acoustic environments, where interference and additive background noise coexist. The problem is formulated as one of convex optimization whose solution under a specified level of interference attenuation leads to an interference controlled maximum noise reduction (ICMR) beamformer, which can be expressed as a linear combination of two MVDR beamformers: one attempts to extract the desired source signal while the other attempts to extract the interference. The combination coefficients are functions of the array manifold vectors, noise coherence matrix, and the specified interference attenuation factor. By tuning the interference attenuation factor, the ICMR beamformer can be implemented to achieve aggressive interference attenuation or even eliminate interference completely; but this may lead to less additive noise suppression or even noise amplification. To control the maximum sacrifice in gain (SG) of the signal-to-noise ratio (SNR) that is acceptable for additive reduction, a variant of ICMR is derived, which is named as the ICMR-SG beamformer. Simulations are performed and the results show that the ICMR beamformer is able to control the amount of interference attenuation. In comparison, ICMR-SG controls the maximum SG of SNR while achieving the optimal possible level of interference attenuation.
The scientific rationale for lateral tenodesis augmentation of intra-articular ACL reconstruction using a modified ‘Lemaire’ procedure (2017)

III.
Dynamic stress-strength approach for reliability prediction (2009)

The role of reliability prediction during the design stage of a system is worldwide recognized. Simulation tools and proper experimental approaches are usually applied to get reliability properties. In this paper, an experimental method relying on the use the dynamic stress-strength approach is presented and applied on a simple electronic device. The obtained results are presented and discussed.
Structural Investigations on Enantiopure P–OP Ligands: A High‐Performing P–OP Ligand for Rhodium‐Catalysed Hydrogenations (2018)

A second generation of phosphine–phosphite (P–OP) ligands, incorporating a more sterically bulky phosphite group than previous P–OP ligand designs, gave very efficient catalysts for the Rh‐catalysed asymmetric hydrogenation of a diverse array of substrates (11 examples, 93–99 % ee ) containing structurally diverse substituents and chelating groups at the C=C double bond. The presence of the sterically bulky ( S a )‐3,3′‐diphenyl‐5,5′,6,6′,7,7′,8,8′‐octahydro‐[1,1′‐binaphthalene]‐2,2′‐diol‐derived phosphite fragment caused significant increases in enantioselectivity (up to Δ ee = 58 %), and provided improved results compared to those obtained with the first generation of P–OP‐derived rhodium catalysts {i.e., rhodium complexes incorporating phosphine–phosphite ligands with ( R a )‐ and ( S a )‐BINOL‐derived phosphite groups; BINOL = [1,1′‐binaphthalene]‐2,2′‐diol}. Overall, the optimal ligand L8 provided very high enantioselectivities for a range of structurally diverse olefins (up to 99 % ee ).
ERMP1, a novel potential oncogene involved in UPR and oxidative stress defense, is highly expressed in human cancer (2016)

Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) are highly activated in cancer and involved in tumorigenesis and resistance to anti-cancer therapy. UPR is becoming a promising target of anti-cancer therapies. Thus, the identification of UPR components that are highly expressed in cancer could offer new therapeutic opportunity.In this study, we demonstrate that Endoplasmic Reticulum Metallo Protease 1 (ERMP1) is broadly expressed in a high percentage of breast, colo-rectal, lung, and ovary cancers, regardless of their stage and grade. Moreover, we show that loss of ERMP1 expression significantly hampers proliferation, migration and invasiveness of cancer cells. Furthermore, we show that this protein is an important player in the UPR and defense against oxidative stress. ERMP1 expression is strongly affected by reticular stress induced by thapsigargin and other oxidative stresses. ERMP1 silencing during reticular stress impairs the activation of PERK, a key sensor of the UPR activation. Loss of ERMP1 also prevents the expression of GRP78/BiP, a UPR stress marker involved in the activation of the survival pathway. Finally, ERMP1 silencing in cells exposed to hypoxia leads to inhibition of the Nrf2-mediated anti-oxidant response and to reduction of accumulation of HIF-1, the master transcription factor instructing cells to respond to hypoxic stress. Our results suggest that ERMP1 could act as a molecular starter to the survival response induced by extracellular stresses. Moreover, they provide the rationale for the design of ERMP1-targeting drugs that could act by inhibiting the UPR initial adaptive response of cancer cells and impair cell survival.
Liposomale Enzym‐Nanoreaktoren auf Basis von Nanoconfinement für eine effiziente Anti‐Tumor‐Therapie (2023)

Abstract Enzymatische Reaktionen können endogene Nährstoffe eines Tumors verbrauchen und zytotoxische Spezies erzeugen und sind daher vielversprechende Werkzeuge für die Behandlung bösartiger Tumore. Inspiriert von der Natur, in der Enzyme in Membranen kompartimentiert sind, um eine hohe Reaktionseffizienz zu erreichen und biologische Prozesse von der Umwelt zu trennen, entwickelten wir liposomale Nanoreaktoren, die enzymatische Kaskadenreaktionen im wässrigen Nanoconfinement des Liposoms durchführen können. Die Nanoreaktoren hemmten das Tumorwachstum in vivo effektiv, indem sie Tumornährstoffe (Glukose und Sauerstoff) verbrauchten und hochgradig zytotoxische Hydroxylradikale (⋅OH) produzierten. Die Ko‐Kompartimentierung von Glukoseoxidase (GOx) und Meerrettichperoxidase (HRP) in Liposomen konnte die lokale Konzentration des Zwischenprodukts Wasserstoffperoxid (H 2 O 2 ) sowie den Säuregrad aufgrund der Bildung von Gluconsäure durch GOx erhöhen. Sowohl H 2 O 2 als auch der Säuregehalt beschleunigten die zweite Stufe der Reaktion durch HRP und verbesserten so die Gesamteffizienz der Kaskadenreaktion. Die biomimetische Kompartimentierung enzymatischer Tandemreaktionen in biokompatiblen Liposomen ist ein vielversprechender Weg für die Entwicklung katalytischer Nanomedikamente für die Antitumortherapie.
Supplementary Figure 2 from Combination of YM155, a Survivin Suppressant, with Bendamustine and Rituximab: A New Combination Therapy to Treat Relapsed/Refractory Diffuse Large B-cell Lymphoma (2023)

&lt;p&gt;PDF file - 131KB, 18F-FLT PET imaging in a SU-DHL-8 disseminated xenograft model.&lt;/p&gt;
Smart Textiles: Position and Motion Sensing for Sport, Entertainment and Rehabilitation (2008)

Innovation in textiles and clothing has embodied various combinations of new and existing materials to meet conventional needs of comfort and fashion. Interactive and intelligent textiles are emerging as many new textile materials are being used to form sensors in garments to intimately interact with the human form. Interactive textiles typically contain sensors located within a garment to detect physiological functions that are wirelessly connected to digital infrastructure and application specific software. These devices can be realised in conventional garments and have scope for application in diverse fields including entertainment, education, sport, military and medicine. Position and Motion Sensing devices will be discussed for each application, in terms of the value proposition, performance requirements, regulations, and existing technology. A case study of an entertainment device that uses limb motion to achieve an imaginary instrument, the Wearable Instrument Shirt (WIS) will be discussed in this context. The WIS combines a wearable sensor interface with software to map gestures and audio data files to form an easy-to-use gesture driven instrument that allows real-time interactive musical performances without any need for significant instrument or computer skills.
Increased dislocation rates following total hip arthroplasty in patients with ankylosing spondylitis (2022)

Older AS patients have higher dislocation rates following THA. This effect is likely related to decreased spinopelvic motion in the sagittal plane, predisposing patients to impinge and dislocate.
How to utilize a sophisticated medical risk model in estate planning (2018)

Just as the medical profession strives to manage health and disease risks to ensure sound health, the estate planning profession strives to manage risks to ensure a client and his or her family's financial health and wellbeing.