gebhart/patrepeval huggingface dataset:
Efficient small data access for machine-type communications in LTE (2013)

In this paper, we address the emerging concept of Machine-Type Communications (MTC), where unattended wireless devices send their data over the Long Term Evolution (LTE) cellular network. In particular, we emphasize that future MTC deployments are expected to feature a very large number of devices, whereas the data from a particular device may be infrequent and small. Currently, LTE is not optimized for such traffic and its data transmission schemes are not MTC-specific. To improve the efficiency of small data access, we propose a novel contention-based LTE transmission (COBALT) mechanism and evaluate its performance with both analysis and protocol-level simulations. When compared against existing alternatives, our data access scheme is demonstrated to improve network resource consumption, device energy efficiency, and mean data access delay. We conclude that COBALT has the potential for supporting massive MTC deployments based on the future releases of the LTE technology.
Basic fibroblast growth factor-Pseudomonas exotoxin chimeric proteins; Comparison with acidic fibroblast growth factor-Pseudomonas exotoxin (1993)

We have constructed growth factor-toxin chimeric molecules composed of basic fibroblast growth factor (bFGF) and two different binding mutant forms of Pseudomonas exotoxin termed bFGF-PE40 and bFGF-PE4E KDEL. The chimeric molecules were expressed in Escherichia coli and localized to both inclusion bodies and the spheroplast cytoplasm. The bFGF-toxin fusion protein that was isolated and purified from inclusion bodies was 3-fold more active in inhibiting protein synthesis than that purified from spheroplast cytoplasm. Immunoreactivity of purified bFGF-toxin fusion protein to anti-bFGF antibodies was similar to that of native bFGF, as determined by ELISA analysis. A variety of carcinoma cell lines were sensitive to bFGF-PE40 and bFGF-PE4E KDEL, including H3396 (breast), Hep G2 (hepatocellular), and A431 (epidermoid). The concentration of chimeric toxin that inhibited protein synthesis by 50% (EC50) was 110, 70, and 18 ng/mL for bFGF-PE40 and 15, 1, and 18 ng/mL for bFGF-PE4E KDEL. In comparison with fusion-toxins composed of acidic fibroblast growth factor (aFGF) and either PE40 or PE4EKDEL, bFGF-PE40 and bFGF-PE4E KDEL were similarly cytotoxic on most cell lines tested. Human aortic smooth muscle cells were sensitive to both bFGF and aFGF toxin fusion proteins. However, human aortic endothelial cells were sensitive to the bFGF-toxins but were resistant to both aFGF-toxin forms. Time course studies showed that bFGF-PE40 needed a 4-6-h exposure to target cells for peak inhibition of protein synthesis on both MCF-7 and A431 cells, while aFGF-PE40 was almost fully active within a 2-h incubation.(ABSTRACT TRUNCATED AT 250 WORDS)
Electrode Performance Test on Single Ceramic Fuel Cells Using as Electrolyte Sr‐ and Mg‐Doped LaGaO3 (1997)

The electrode performance of a single solid oxide fuel cell was evaluated using a 500 μm thick La0.9Sr0.1Ga0.8Mg0.2O2.85 (LSGM) as the electrolyte membrane. Comparison of La0.6Sr0.4CoO3-δ (LSCo) and La0.9Sr0.1MnO3 (LSM) as cathodes showed LSCo gave an exchange current density two orders of magnitude higher than that of LSM. Comparison of CeO2/Ni and LSGM/Ni as anodes showed a degradation of the latter with time, and studies of the anode‐electrolyte interface and the reactivity of NiO and LSGM suggest better anode performances can be obtained with a buffer layer that prevents formation of LaNiO3 . The cell performance showed that, with a proper choice of electrode materials and LSGM as the electrolyte, a SOFC operating at temperatures 600°C &lt; Top &lt; 800°C is a realistic goal.
Sterol biosynthesis via cycloartenol and other biochemical features related to photosynthetic phyla in the amoebae Naegleria lovaniensis and Naegleria gruberi (1987)

The sterols and sterol precursors of two amoebae of the genus Naegleria, Naegleria lovaniensis and Naegleria gruberi were investigated. Cycloartenol, the sterol precursor in photosynthetic organisms, is present in both amoebae. In N. lovaniesis, it is accompanied by lanosterol and parkeol, as well as by the 24,25-dihydro derivatives of these triterpenes. One of the most striking features of these amoebae is the accumulation of 4 alpha-methylsterols which are present in similar amounts as those of 4,4-desmethylsterols (3-5 mg/g, dry weight). 4 alpha-Methylergosta-7,22-dienol was identified as a new compound. Ergosterol was the major 4,4-desmethylsterol, accompanied by small amounts of C27 and other C28 sterols. Treatment of N. lovaniensis with fenpropimorph modified the sterol pattern of this amoeba and inhibited its growth. This fungicide, known to inhibit steps of sterol biosynthesis in fungi and plants, induced the disappearance of 4 alpha-methyl-delta 7-sterols and the appearance of the unusual delta 6,8,22-ergostatrienol as in A. polyphaga. These results might be explained by a partial inhibition of the delta 8----delta 7 isomerase, the small amounts of delta 7-sterols formed being converted into ergosterol which is still present in fenpropimorph-exposed cells. De novo sterol biosynthesis in N. lovaniensis was shown by incorporation of [1-14C]acetate into sterols and sterol precursors, especially cycloartenol. Lanosterol and parkeol were not significantly labelled. Furthermore, [3-3H]squalene epoxide was efficiently cyclized by a cell-free system of this amoeba into cycloartenol, and again no significant radioactivity was detected in lanosterol and parkeol. This shows that cycloartenol, the sterol precursor in plants and algae, is also the sterol precursor in Naegleria species, and that these amoebae, like A. polyphaga, are related by some biosynthetic pathways to photosynthetic phyla. Lanosterol, the sterol precursor in non-photosynthetic phyla (animal and fungi) and parkeol are more likely dead-ends of this biosynthetic pathway. The peculiar phylogenetic position of these protozoa was further emphasized by the action of indole acetic acid and other auxine-like compounds on their growth. Indeed amoebic growth was enhanced in the presence of these higher plant growth hormones. The differences in the sterol composition of the protozoa we have hitherto examined is related to their sensitivity toward polyene macrolide antibiotics.(ABSTRACT TRUNCATED AT 400 WORDS)
GAME INTERFACE FOR LOCATION LEARNING (2015)

A location learning system can be used for learning layout of a geographic location like a neighborhood, city, district, state, etc. The system provides a user with a gaming application to facilitate user learning of routes from one location to another. When the user starts the game, the system displays panoramas of a starting and a target geographic location. The system provides a user interface projectile that the user can project, throw, shoot, or launch towards the target geographic location. The system receives a gesture to project the user interface projectile from the starting location towards the target geographic location. The system calculates a landing location and a trajectory based upon values like direction, ground angle, and speed associated with the gesture. The system plays an animation along the trajectory of the projectile. The animation shows panoramas of surrounding environment of the determined trajectory. In this manner, the user can learn how various locations are situated in relation to each other. PROBLEM STATEMENT With the advent of navigation applications, finding places has become quite easy. Navigation applications provide users with maps that are efficient in showing or guiding users to the target location that they wish to visit. However, users need to have a good sense of direction to understand maps. Thus, maps might not be the most helpful for users to determine where places are in relation to each other within a geographic location like a city, state, etc. Many users prefer navigating by landmarks instead of picturing a map in their head (e.g., Turn left at the
p53 associates with and targets ΔNp63 into a protein degradation pathway (2001)

A human p53 homologue, p63 (p40/p51/p73L/CUSP) that maps to the chromosomal region 3q27-29 was found to produce a variety of transcripts that encode DNA-binding proteins with and without a trans-activation domain (TA- or Delta N-, respectively). The p63 gene locus was found to be amplified in squamous cell carcinoma, and overexpression of Delta Np63 (p40) led to increased growth of transformed cells in vitro and in vivo. Moreover, p63-null mice displayed abnormal epithelial development and germ-line human mutations were found to cause ectodermal dysplasia. We now demonstrate that certain p63 isotypes form complexes with p53. p53 mutations R175H or R248W abolish the association of p53 with p63, whereas V143A or R273H has no effect. Deletion studies suggest that the DNA-binding domains of both p53 and p63 mediate the association. Overexpression of wild type but not mutant (R175H) p53 results in the caspase-dependent degradation of certain Delta Np63 proteins (p40 and Delta Np63 alpha). The association between p53 and Delta Np63 supports a previously unrecognized role for p53 in regulation of Delta Np63 stability. The ability of p53 to mediate Delta Np63 degradation may balance the capacity of Delta Np63 to accelerate tumorigenesis or to induce epithelial proliferation.
Tunable optical delay line based on Si<inf>3</inf>N<inf>4</inf> ring resonators (2017)

We demonstrate a tunable optical time delay line based on Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> ring resonators. A continuously tunable 1.4 ns optical delay is achieved with over 3.5 GHz bandwidth. The maximum tunable delay can be easily extended to several nanoseconds by modifying the ring coupler κ.
Thermisch gespritzte, keramische Zylinderlaufbahnen unter Misch‐/Grenzreibung (2004)

Abstract Einen großen Beitrag zur Gewichtseinsparung leistet die Substitution von Grauguss‐Legierungen durch moderne Aluminiumlegierungen für Pkw Kurbelgehäuse. Zur Erhöhung der tribologischen und thermomechanischen Belastungsgrenzen von Aluminiumoberflächen kommen thermisch gespritzte Schichten in Frage. Zielsetzung nachfolgender Untersuchungen ist es außermotorisch unter Misch‐/Grenzreibung das tribologische Potenzial von thermisch gespritzten keramischen Schichtwerkstoffen auf Basis der Stoffsysteme Cr 2 O 3 , Cr 2 O 3 /TiO 2 , Cr 3 C 2 /NiCr, TiO 2 , TiO 2 /Al 2 O 3 im Vergleich zu aktuell serienmäßig eingesetzten Graugusswerkstoffen zu ermitteln. Die Oberflächentopographien und die Schmierstoffe determinieren gegenüber GG26Cr die Verschleißsenkungspotenziale der keramischen Schichten. Eine Reduzierung der Reibungszahlen wird nicht durch keramische Oberflächenbeschichtungen, sondern durch den Einsatz von Polyglykolen als Schmiermedium erzielt.
USE OF MODULAR IMPLANTS MADE OF POROUS TANTALUM FOR THE TREATMENT OF SEVERE BONE DEFECTS IN REVISION HIP SURGEY (2008)

Purpose of the study: The majority of acetabular bone defects observed during revision hip surgery can be treated with a hemispheric implant, associated or not with a bone graft. In many patients however, loss of bone stock is so great that a more complex system must be used with a sustaining ring, multilobulated implants, or massive allografts. All have their technical difficulties or problems with fixation. The purpose of this work was to evaluate a new technique for acetabular reconstruction using modular implants fashioned with a new biomaterial, porous tantalum, which had specific properties favoring osteointegration. Material and methods: These modular implants were fashioned so as to enable reconstruction of the acetabular cavity in cases with complex loss of bone stock. The design allows simultaneous biological incorporation and mechanical support with a press-fit hemispheric cup. These implants were used for 16 hips (16 patients, 12 women and 4 men, mean age 63.6 years, age range 34–86 years). These patients were followed for 31.9 months on average (range 24–39 months). The acetabular defects were Paprosky 2A (n=1), 2B ‘n=3), 2C (n=1), 3A (n=5), 3B (n=6). On average, these patients had undergone 2.8 cup replacements (1–9) on the same hip. Results: The mean Harris hip score improved from 39.31 (range 33–52) preoperatively to 75.18 (range 52–92) at last follow-up. Preoperatively, the center of rotation of the prosthetic hip was situated a a mean horizontal distance of 18.6 mm (range −3 to 46 mm) and a mean vertical distance of 27.6 mm (range −16 to 52 mm) from the ideal center of rotation according to Ranawat. Postoperatively, the prosthetic center of rotation was situated at a mean horizontal distance of 10.5 mm (range 1–25 mm) and a mean vertical distance of 7.4 mm (range −15 to 25 mm) front the ideal center of rotation. None of the implants presented loosening or migration at last follow-up. Discussion: At short-term follow-up, this modular system for acetabular reconstruction has provided good results for acetabular reconstruction which can accept a hemispheric cup alone and which would have required use of other reconstruction methods such as structural allografts, sustaining rings or other. Conclusion: A longer follow-up will be needed to determine whether these good clinical and radiological results persist with time.
Double-Stage Spectral Broadening in Bulk Crystals of 50 W, 1.3 μJ, 250 fs pulses to a Fourier transform limit of 15 fs (2015)

Spectral broadening of 1.3-μJ, 250-fs pulses in crystalline quartz is presented. Pulse compression to 43-fs was achieved by mans of broadening in a single 15-mm crystal. A second stage reduced the transform limit to 15-fs.
Stochastic Modeling and Prediction of Experimental Seizures in Sprague-Dawley Rats (2001)

Most seizure prediction methods are based on nonlinear dynamic techniques, which are highly computationally expensive, thus limiting their clinical usefulness. The authors propose a different approach for prediction that uses a stochastic Markov chain model. Seizure (Ts) and interictal (Ti) durations were measured from 11 rats treated with 3-mercaptopropionic acid. The duration of a seizure Ts was used to predict the time (Ti2) to the next one. Ts and Ti were distributed bimodally into short (S) and long (L), generating four probable transitions: S --> S, S --> L, L --> S, and L --> L. The joint probability density f (Ts, Ti2) was modeled, and was used to predict Ti2 given Ts. An identical model predicted Ts given the duration Ti1 of the preceding interictal interval. The median prediction error was 3.0 +/- 3.5 seconds for Ts (given Ti1) and 6.5 +/- 2.0 seconds for Ti2 (given Ts). In comparison, ranges for observed values were 2.3 seconds < Ts < 120 seconds and 6.6 seconds < Ti < 782 seconds. These results suggest that stochastic models are potentially useful tools for the prediction of seizures. Further investigation of the probable temporal interdependence between the ictal and interictal states may provide valuable insight into the dynamics of the epileptic brain.
Domain name based network interface selection (2008)

A multi-homed host with multiple physical and/or virtual network
interfaces has to select which one of the network interfaces to use
for a new outgoing IPv4 or IPv6 connection. This document describes a
method to select an interface by using destination's fully
qualified domain name and DNS suffix information received dynamically
for each network interface. The method is useful, for example, in
split horizon DNS and walled garden scenarios, where right network
interface has to be selected even before DNS resolution is conducted.
Monolithic InGaAs-on-silicon detector with a CMOS-switched capacitor integrator (1994)

We have successfully grown InGaAs detectors on the silicon substrate using the special technique of selective epitaxy. Small diameter (50 micrometers ) selective area depositions of In<SUB>0.5</SUB>Ga<SUB>0.5</SUB>As on silicon have exhibited a lower dislocation density, and hence, better electrical performance. These InGaAs detectors are grown by Molecular Beam Epitaxy (MBE). The final goal is to monolithically integrate InGaAs detectors with a silicon CMOS switched capacitor integrator. We have designed a CMOS switched-capacitor integrator (SCI) to realize a linear current-to-voltage conversion over a wide voltage range (-5 to +5 V) with low noise characteristics. The SCI circuit consists of an operational amplifier with a feedback capacitor and a reset switch. The SCI circuit uses +/- 5 V dual power supply and one -5 to +5 V voltage pulse generator. The circuit was simulated using PSPICE and the chip layout was done with the Mentor Graphics.
Attentive Statistics Pooling for Deep Speaker Embedding (2018)

This paper proposes attentive statistics pooling for deep speaker embedding in text-independent speaker verification. In conventional speaker embedding, frame-level features are averaged over all the frames of a single utterance to form an utterance-level feature. Our method utilizes an attention mechanism to give different weights to different frames and generates not only weighted means but also weighted standard deviations. In this way, it can capture long-term variations in speaker characteristics more effectively. An evaluation on the NIST SRE 2012 and the VoxCeleb data sets shows that it reduces equal error rates (EERs) from the conventional method by 7.5% and 8.1%, respectively.
JAK‐STAT core cancer pathway: An integrative cancer interactome analysis (2022)

Through a comprehensive review and in silico analysis of reported data on STAT-linked diseases, we analysed the communication pathways and interactome of the seven STATs in major cancer categories and proposed rational targeting approaches for therapeutic intervention to disrupt critical pathways and addictions to hyperactive JAK/STAT in neoplastic states. Although all STATs follow a similar molecular activation pathway, STAT1, STAT2, STAT4 and STAT6 exert specific biological profiles associated with a more restricted pattern of activation by cytokines. STAT3 and STAT5A as well as STAT5B have pleiotropic roles in the body and can act as critical oncogenes that promote many processes involved in cancer development. STAT1, STAT3 and STAT5 also possess tumour suppressive action in certain mutational and cancer type context. Here, we demonstrated member-specific STAT activity in major cancer types. Through systems biology approaches, we found surprising roles for EGFR family members, sex steroid hormone receptor ESR1 interplay with oncogenic STAT function and proposed new drug targeting approaches of oncogenic STAT pathway addiction.
EPR and ENDOR investigation of daunomycin and adriamycin semiquinones (1988)

Abstract Electron spin resonance and ENDOR spectra of semiquinones from daunomycin, adriamycin, their derviatives and model compounds are reported. Hyperfine coupling constants were assigned with the help of TRIPLE resonance and partial deuteration. In contrast to published results, the data obtained were interpreted on the basis of a rapid conformational interconversion of ring A with participation of half chair and boat conformers.
Misconceptions and Game Form Recognition: Challenges to Theories of Revealed Preference and Framing (2014)

This study explores the tension between the standard economic theory of preference and nonstandard theories of preference that are motivated by an underlying theory of framing. A simple experiment fails to measure a known preference. The divergence of the measured preference from the known preference reflects a mistake, arising from some subjects’ misconception of the game form. We conclude that choice data should not be granted an unqualified interpretation of preference revelation. Mistakes in choices obscured by a possible error at the foundation of the theory of framing can masquerade as having been produced by nonstandard preferences.
Figures S1-S2 from Expression of Adipocyte/Macrophage Fatty Acid–Binding Protein in Tumor-Associated Macrophages Promotes Breast Cancer Progression (2023)

&lt;p&gt;Figure S1 shows PROGgene anaysis of FABP/breast cancer survival associations in TCGA dataset. Figure S2 shows immunopheotype of naive WT and A-FABP-/- mice.&lt;/p&gt;
Reactions of tetrasulfur tetranitride with aryl dibromomethyl ketones: one-pot synthesis of 3-aroylformamido-4-aryl-1,2,5-thiadiazoles and their reactions (1995)

Heating of dibromomethyl aryl ketones with tetrasulfur tetranitride (S4N4) at 115 °C without a solvent gave 3-aroylformamido-4-aryl-1,2-5-thiadiazoles 8 as major products (12–71%) and 3,5-diaroyl-1,2,4-thiadiazoles 2 as minor products in certain cases. The structures of compounds 8 were determined based on the X-ray analysis of 3-benzoylformamido-4-phenyl-1,2,5-thiadiazole 8a and comparison with an authentic sample of comound 8a, as well as all the spectroscopic and analytical data of compounds 8. Oxidation of compounds 8 with m-chloroperbenzoic acid in chloroform at room temperature gave compounds 2(0–66%), whereas reduction of compounds 8 with sodium boranuide in a mixture of chloroform–ethanol at room temperature gave 3-amino-4-aryl-1,2,5-thiadiazoles 10(71–93%). Treatment of 3-(3-nitrobenzoylformamido)-4-(3-nitrophenyl)-1,2,5-thiadiazole 8d with either sodium hydroxide in aqueous p-dioxane at reflux or sodium hydride in chloroform at room temperature gave 3-amino-4-(3-nitrophenyl)-1,2,5-thiadiazole 10d in 56 and 80% yield, respectively.
Active Surveillance for Influenza A Virus among Swine, Midwestern United States, 2009–2011 (2013)

Veterinary diagnostic laboratories identify and characterize influenza A viruses primarily through passive surveillance. However, additional surveillance programs are needed. To meet this need, an active surveillance program was conducted at pig farms throughout the midwestern United States. From June 2009 through December 2011, nasal swab samples were collected monthly from among 540 groups of growing pigs and tested for influenza A virus by real-time reverse transcription PCR. Of 16,170 samples, 746 were positive for influenza A virus; of these, 18.0% were subtype H1N1, 16.0% H1N2, 7.6% H3N2, and 14.5% (H1N1)pdm09. An influenza (H3N2) and (H1N1)pdm09 virus were identified simultaneously in 8 groups. This active influenza A virus surveillance program provided quality data and increased the understanding of the current situation of circulating viruses in the midwestern US pig population.
High-average-power Ce:LiCaF laser at 1-KHz repetition rate tunable from 280 nm to 315 nm (1998)

We report on the generation and potential applications of an UV light source tunable from 280 nm to 315 nm with an average power of more than 0.5 W and high absolute conversion efficiency. Overall conversion from the diode pumped Nd:YAG laser fundamental (1064 micrometers ) wavelength to the tunable output exceeded 6%, and an absolute efficiency of Ce:LiCaF laser to the 266 nm pump was in excess of 27%. The diode pumped Nd:YAG laser used in the experiments delivered 1.9 W of average power at 266 nm by successive doubling and quadrupling of 8 W output at 1064 mum. The advantage of using 1 kHz pulsed-diode pumped Nd:YAG laser source lies in relatively high energy per pulse, as compared to the systems with continuous diode pumping, thus allowing high conversion efficiency into fourth harmonic. The fourth harmonic output beam was slightly focused into a 5 mm long Ce(2at.%):LiCaF crystal with AR coated faces. The relatively large energy of the pump pulses resulted in a large beam cross-section in the crystal, thus allowing efficient quasicollinear longitudinal pumping. The laser was tunable from 280 nm to 315 nm. The output linewidth varied from 0.3 to 0.6 nm, depending on spectral position and the pump power. Applications in microelectronic and optoelectronic manufacturing will be discussed.