gebhart/patrepeval huggingface dataset:
Signal pathway profiling of ovarian cancer from human tissue specimens using reverse‐phase protein microarrays (2003)

Defects in cell signaling pathways play a central role in cancer cell growth, survival, invasion and metastasis. An important goal of proteomics is to characterize and develop "circuit maps" of these signaling pathways in normal and diseased cells. We have used reverse-phase protein array technology coupled with laser capture microdissection and phospho-specific antibodies to examine the activation status of several key molecular "gates" involved in cell survival and proliferation signaling in human ovarian tumor tissue. The levels of activated extracellular-regulated kinase (ERK1/2) varied considerably in tumors of the same histotype, but no significant differences between histotypes were observed. Advanced stage tumors had slightly higher levels of phosphorylated ERK1/2 compared to early stage tumors. The activation status of Akt and glycogen synthase kinase 3beta, key proteins and indicators of the state of the phosphatidylinositol 3-kinase/Akt pro-survival pathway also showed more variation within each histotype than between the histotypes studied. Our results demonstrate the utility of reverse phase protein microarrays for the multiplexed analysis of signal transduction from discreet cell populations of cells procured directly from human ovarian tumor specimens and suggest that patterns in signal pathway activation in ovarian tumors may be patient-specific rather than type or stage specific.
(−)-Epigallocatechin- 3 -gallate is a new inhibitor of hepatitis C virus entry (2011)

EGCG is a new, interesting anti-HCV molecule that could be used in combination with other direct-acting antivirals. Furthermore, it is a novel tool to further dissect the mechanisms of HCV entry into the hepatocyte.
Filling cavities or restoring teeth? (2011)

Teeth seldom fracture under normal functional loading. This indicates that the natural tooth design is optimized for the distribution of regular masticatory forces by means of its properties and structure. When a tooth is restored with an intracoronal restoration, however, the incidence of tooth fracture increases. Since remaining tissues do not change, the restorative actions apparently alter the original stress distributions. In this study, the effect of different restoration types (unbonded amalgam and bonded composite restorations) were compared with the original stress conditions of the intact tooth, using finite element analysis. It was shown that an unbonded amalgam restoration did not restore the original stress conditions but led to much higher stresses in the buccal and lingual enamel and to higher tensile stresses in the cavity floor. The unbonded amalgam thus filled the cavity but did not restore the tooth. In contrast, a bonded composite restoration restored the original stress pattern in the tooth if there was no polymerization shrinkage. Polymerization shrinkage causes residual tensile stresses in the dentin around the cavity and in the buccal and lingual enamel. Residual tensile stresses in the buccal and lingual enamel are momentary compensated by compressive stress components during occlusal loading. It was concluded that bonding and elimination of residual stresses are prerequisites for restoring the original tooth integrity.
Reconstruction en imagerie gamma à partir d'acquisitions multi-énergie (2007)

This article deals with the reconstruction of radionuclide distribution in emission imaging. We propose a reconstruction scheme that takes advantage of data obtained from a spectrometric CdZnTe detector, included scatter events. An example of reconstruction from multiple-energy acquisitions is presented and evaluated.
Synthesis and Supramolecular Assemblies of Bipolar Archaeal Glycolipid Analogues Containing a cis-1,3-Disubstituted Cyclopentane Ring (2004)

Unsymmetrical archaeal tetraether glycolipid analogues 1-2 incorporating a 1,3-disubstituted cyclopentane ring into the bridging chain have been synthesized. The cyclopentane has been introduced with a totally controlled cis configuration, either into the middle of the aliphatic chain or at three methylene groups from the glycerol unit linked to the bulkier disaccharide residue. Freeze-fracture and cryotransmission electron microscopy experiments clearly demonstrated unprecedented glycolipid supramolecular organizations involving two-by-two monolayer associations coupled with interconnection and fusion phenomena. Furthermore, a significant difference in the hydration properties and in the lyotropic liquid crystalline behavior of bipolar lipids 1-2 was found depending on the position of the cyclopentane residue.
Radiation standards and calibrations. FY-1981 annual report (1982)

The research program encompasses: reviewing calibration standards, regulations, and handbooks; assuring that calibration procedures used are in agreement with technically accepted methods; maintaining basic radioactive sources and instruments that serve as radiological standards; and providing traceability to the National Bureau of Standards where possible. In addition, major efforts are being expended to upgrade the 318 calibration facility. This report focuses on major accomplishments during FY-1981. However, most maintenance and quality assurance efforts involve routine support and only a summary report is provided. (PSB)
Is LiFePO[sub 4] Stable in Water? (2007)

International audience
Recursive Sandboxes: Extending Systrace to Empower Applications (2004)

The systrace system-call interposition mechanism has become a popular method for containing untrusted code through program-specific policies enforced by user-level daemons. We describe our extensions to systrace that allow sand-boxed processes to further limit their children processes by issuing dynamically constructed policies. We discuss our extensions to the systrace daemon and the OpenBSD kernel, as well as a simple API for constructing simple policies. We present two separate implementations of our scheme, and compare their perfor mance with the base systrace system. We show how our extensions can be used by processes such asftpd, sendmail, and sshd.
Computer‐assisted dental implant surgery using computed tomography (1995)

Standard planning for dental implants consists of a prosthesis simulation on diagnostic casts and radiographic examination of anatomical structures. The clinician visually locates the planned trajectory on the surgical site in the patient's mouth without direct correlation between the radiographs and the anatomy. We have developed a computer assisted technique to define the optimal position of the bone implant using computed tomography to accurately place the implant in the planned position using a guide drilled into a resin splint. J Image Guid Surg 1:53-58 (1995). © 1995 Wiley-Liss, Inc.
EFFECTSOFTHEMULTI-SWITCHEXCITATIONON THE RESPONSIVENESSOFA BLUMLEINLINE* (2005)

triggering. Alltheresults hereareproduced using CST Microwave StudiolM, a3D-electromagnetic solver. Thispaperinvestigates theeffects thatmulti-switch excitation hasontheresponse ofaparallel-plate Blumlein line. Inparticular, ittests apractical limit onthenumber II.COMPARISONS ofswitches beyondwhichnochangeisobserved. The results areshowninterms ofthepulse width, shape, and Tobetter observe theeffects ofmulti-switch excitation, themaximumelectrical field inside theline. Finally, non- weapplyittoafewmodellines ofdifferent widths. We uniform switch spacing isstudied todetermine anyfurthercomparethelineresponse toa growingnumberof benefit. switches ineachmodelinterms ofthepulse widthonthe load, andmaximumelectric field. Following that, the pulse robustness against theimperfect triggering ofthe
Supplementary Figures Legends 1-3 from <i>CMTM3</i>, Located at the Critical Tumor Suppressor Locus 16q22.1, Is Silenced by CpG Methylation in Carcinomas and Inhibits Tumor Cell Growth through Inducing Apoptosis (2023)

Supplementary Figures Legends 1-3 from &lt;i&gt;CMTM3&lt;/i&gt;, Located at the Critical Tumor Suppressor Locus 16q22.1, Is Silenced by CpG Methylation in Carcinomas and Inhibits Tumor Cell Growth through Inducing Apoptosis
A New Test for Preimplantation Genetic Testing of Aneuploidy (PGT-A) and Structural Chromosomal Imbalances (PGT-SR) Is Non-inferior to Current Platforms but Still Not Clinically Useful (2023)

Journal Article A New Test for Preimplantation Genetic Testing of Aneuploidy (PGT-A) and Structural Chromosomal Imbalances (PGT-SR) Is Non-inferior to Current Platforms but Still Not Clinically Useful Get access Pasquale Patrizio, Pasquale Patrizio Department of Obstetrics, Gynecology and Reproductive Sciences, University of Miami, Miller School of Medicine, Miami, FL, United States Address correspondence to this author at: Department of Obstetrics, Gynecology and Reproductive Sciences-Division of Reproductive Endocrinology and Infertility, University of Miami, Miller School of Medicine, Miami, FL, USA. E-mail: pxp612@med.miami.edu. https://orcid.org/0000-0003-4796-7078 Search for other works by this author on: Oxford Academic Google Scholar Norbert Gleicher Norbert Gleicher The Center for Human Reproduction, New York, NY, United StatesThe Brivanlou Laboratory, Rockefeller University, New York, NY, United StatesThe Foundation for Reproductive Medicine, New York, NY, United StatesDepartment of Obstetrics and Gynecology, Vienna University School of Medicine, 1009 Vienna, Austria Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 69, Issue 8, August 2023, Pages 791–792, https://doi.org/10.1093/clinchem/hvad087 Published: 17 July 2023 Article history Received: 16 May 2023 Accepted: 06 June 2023 Published: 17 July 2023
Reliability of aerodynamic analysis using a moment method (2009)

In this study, a reliability analysis was performed for the aerodynamic analysis. Among various reliability analysis methods, the moment method was used and the results were compared with other methods. The reliability of aerodynamic analysis of a 2D airfoil, a 3D wing and a wing body configuration were considered. In the case of 2D airfoil, the reliability was computed by parameterising an airfoil shape using the PARSEC function and considering uncertainties of its shape. In the case of 3D wing and wing body configuration, it was computed by considering uncertainties of flow conditions.
Curvilinear electronics: Small 23/2009 (2009)

The cover picture shows an SEM image of a curvilinear integrated circuit built using islands of monocrystalline silicon membranes electrically and mechanically interconnected by thin, arc-shaped ribbons comprising polymer and metal films. Elastomeric transfer elements enable such circuits, which are originally fabricated in planar geometries, to be conformally wrapped onto substrates with complex curvilinear shapes. Mechanics modeling reveals the underlying physics of deformation in these systems. Circuits configured into a wide variety of curvlinear layouts illustrate the versatility of the concepts, and foreshadow application possibilities that cannot be addressed using conventional technologies based on planar, rigid semiconductor wafers. For more information, please read the Full Paper “Curvilinear Electronics Formed Using Silicon Membrane Circuits and Elastomeric Transfer Elements” by J. S. Ha, Y. Huang, J. A. Rogers, et al., beginning on page 2703.
Spoken Dialog Challenge 2010: Comparison of Live and Control Test Results (2011)

The Spoken Dialog Challenge 2010 was an exercise to investigate how different spoken dialog systems perform on the same task. The existing Let's Go Pittsburgh Bus Information System was used as a task and four teams provided systems that were first tested in controlled conditions with speech researchers as users. The three most stable systems were then deployed to real callers. This paper presents the results of the live tests, and compares them with the control test results. Results show considerable variation both between systems and between the control and live tests. Interestingly, relatively high task completion for controlled tests did not always predict relatively high task completion for live tests. Moreover, even though the systems were quite different in their designs, we saw very similar correlations between word error rate and task completion for all the systems. The dialog data collected is available to the research community. © 2011 Association for Computational Linguistics.
The Reaction of LiAlH4 with 1,4-Di-tert-butyl-1,4-diazabutadiene:  Imine-Containing Aluminum Hydrides Stabilized by Lithium Coordination (1999)

The reaction of 1,4-di-tert-butyl-1,4-diazabutadiene, 1, with purified LiAlH(4) (free from Al metal) in diethyl ether has been investigated in detail, and a range of products have been isolated. The lithium diamidoaluminum dihydride [Li{N(t-Bu)CHCH(2)N-t-Bu}(2)AlH(2)], 2, the dimeric diamidoaluminum hydride [cis-{[&mgr;-N(t-Bu)CH(2)CH(2)N-t-Bu]AlH}(2)], 3, or the heteroleptic lithium tetraamidoaluminum species [(Et(2)O)Li{N(t-Bu)CH(2)}(2)(CHN-t-Bu)(2)Al], 4, can be selectively obtained depending on the order of addition or stoichiometry of the reactants. We have rationalized these results in terms of the unstable adducts which are likely to be present in solution at low temperature. The X-ray crystal structures of 2 and the dimeric lithium aluminum hydride adduct [{[HN(t-Bu)CH(t-Bu)CHN-t-Bu]Li(&mgr;-H)(2)AlH(2)}(2)], 7, are described.
Development of a chemical kinetic model for the combustion of a synthesis gas from a fluidized-bed sewage sludge gasifier in a thermal oxidizer (2014)

The need for sustainability has been on the rise. Municipalities are finding ways of reducing waste, but also finding ways to reduce energy costs. Waste-to-energy is a sustainable method that may reduce bio-solids volume while also producing energy. In this research study bio-solids enters a bubbling bed gasifier and within the gasifier a synthesis gas is produced. This synthesis gas exits through the top of the gasifier and enters a thermal oxidizer for combustion. The thermal oxidizer has an innovative method of oxidizing the synthesis gas. The thermal oxidizer has two air injection sites and the possibility for aqueous ammonia injection for further NOx reduction. Most thermal oxidizers already include an oxidizer such as air in the fuel before it enters the thermal oxidizer; thus making this research and operation different from many other thermal oxidizers and waste-to-energy plants. The reduction in waste means less volume loads to a landfill. This process significantly reduces the amount of bio-solids to a landfill. The energy produced from the synthesis is beneficial for any municipality, as it may be used to run the waste-to-energy facility. The purpose of this study is to determine methods in which operators may configure future plants to reduce NOx emissions. NOx mixed with volatile organic compounds (VOC) and sunlight, produce ozone (O3) a deadly gas at high concentrations. This study developed a model to determine the best methods to reduce NOx emissions. Results indicate that a fuel-rich then fuel-lean injection scheme results in lower NOx emissions. This is because at fuel-rich conditions not all of the ammonia in the first air ring is converted to NOx, but rather a partial of the ammonia is converted to NOx and N2 and then the second air ring operates at fuel-lean which further oxidizes the remaining ammonia which converts to NOx, but also a fraction to N2. If NOx standards reach more stringency then aqueous ammonia injection is a recommended method for NOx reduction; this method is also known as selective non-catalytic reduction (SNCR). The findings in this study will allow operators to make better judgment in the way that they operate a two air injection scheme thermal oxidizer. The goal of the operator and the organization is to meet air quality standards and this study aims at finding ways to reduce emissions, specifically NOx.
Antibacterial properties of Ro 40-6890, a broad-spectrum cephalosporin, and its novel orally absorbable ester, Ro 41-3399 (1992)

Ro 41-3399 is a novel orally active ester of Ro 40-6890, an aminothiazolyl cephalosporin with potent in vitro activities against commonly encountered aerobic gram-positive bacteria (streptococci and methicillin-susceptible staphylococci) and gram-negative bacteria (members of the family Enterobacteriaceae, haemophili, meningococci, and gonococci). In terms of the MICs determined by the methods recommended by the National Committee for Clinical Laboratory Standards, for 50 and 90% of gram-positive organisms, the water-soluble free carboxylic acid Ro 40-6890 proved to be at least as active as or two- to fourfold more active than cefpodoxime, cefuroxime, cefaclor, amoxicillin, amoxicillin-clavulanic acid, and ceftriaxone; against aerobic gram-negative organisms, Ro 40-6890 was usually two- to fourfold more active than cefpodoxime, the next most potent of the oral drugs under comparison, but remained usually two- to fourfold weaker than ceftriaxone. Ro 40-6890 showed a high affinity for the essential penicillin-binding proteins of susceptible bacteria and was resistant to hydrolysis by a broad array of beta-lactamases. Ro 41-3399 bopentil was well absorbed in mice when administered by oral gavage and proved effective in several experimental bacterial infections. Further studies with Ro 41-3399 and Ro 40-6890 are in progress.
Noninterferometric reconstruction of optical-field correlations (1994)

A noninterferometric method for reconstructing the second-order correlations of a partially coherent optical field is described. It is assumed that the field propagates close to one particular direction, so that the paraxial approximation may be used, and that the field correlations in some cross section may be well approximated by the quasihomogeneous model. Two reconstruction formulas are derived which uniquely determine the cross-spectral density function, characterizing the correlations, from knowledge of the spatial distribution of the spectral density in several parallel planes.
CVD Material Processing. Effects of Pressure and Gas Feed Rate on Growth Rate Profile of GaN Thin Film in Vertical MOCVD Reactor. (2000)

トリメチルガリウム (TMG) とNH3を原料ガスとして用いた有機金属化学気相析出法 (MOCVD法) によるGaNエピタキシャル薄膜の製造に及ぼす, 反応器内圧力とガス流量の影響を実験とシミュレーションの両面から検討した. 実験では枚葉式の垂直型コールドウォール反応器中で1, 373Kに加熱した基板上に成膜したGaN薄膜の膜厚分布を測定した. 薄膜生成過程のシミュレーションを行うために, TMGとNH3が気相中でアダクトと重合体を生成する反応をモデル化し, これを考慮した反応器内の流速, 温度, 化学種の濃度の分布の数値計算によって成膜速度分布を予測した. 計算結果は, 反応器内の圧力を大気圧から1/8に減少させたときの成膜速度の変化, ならびに減圧下での流量の増大による膜厚分布の平坦化をうまく説明した. 計算結果の検討により, 成膜速度分布の変化は, 基板上の成膜種の濃度分布が反応器内の循環流などに影響されたことに起因していると結論づけられた.
Raman spectroscopic study of the formation of barium titanate from an oxalate precursor (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRaman spectroscopic study of the formation of barium titanate from an oxalate precursorPrabir K. Dutta, P. K. Gallagher, and Jen TwuCite this: Chem. Mater. 1993, 5, 12, 1739–1743Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/cm00036a011https://doi.org/10.1021/cm00036a011research-articleACS PublicationsRequest reuse permissionsArticle Views638Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Broadband Optical Chirality Using Ultrathin Metasurface (2013)

A metasurface layer of λ/50 thickness is developed to produce the optical rotation effect of chiral media through the use of a plasmonic nano-antenna array that generates a phase-shift between helical components of incident light.
Selective trapping of dienes by benzylideneacetoneiron tricarbonyl. Synthesis and thermal rearrangement of tricyclo[4.4.0.02,5]deca-7,9-diene and tricyclo[4.3.0.07,9]nona-2,4-diene (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelective trapping of dienes by benzylideneacetoneiron tricarbonyl. Synthesis and thermal rearrangement of tricyclo[4.4.0.02,5]deca-7,9-diene and tricyclo[4.3.0.07,9]nona-2,4-dieneGary Scholes, Charles R. Graham, and Maurice BrookhartCite this: J. Am. Chem. Soc. 1974, 96, 17, 5665–5667Publication Date (Print):August 1, 1974Publication History Published online1 May 2002Published inissue 1 August 1974https://pubs.acs.org/doi/10.1021/ja00824a106https://doi.org/10.1021/ja00824a106research-articleACS PublicationsRequest reuse permissionsArticle Views89Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Detection of prostate cancer by contrast-ultrasound dispersion imaging (2013)

Despite the development of several efficient focal therapies for prostate cancer, treatment options are often restricted to radical treatments, such as a radical prostatectomy. One of the main obstacles preventing a wider application of focal therapies is the lack of reliable imaging methods for prostate cancer.\nContrast-ultrasound dispersion imaging (CUDI) is a recently introduced method for detection and localization of prostate cancer, based on dynamic contrast-enhanced ultrasound (DCE-US) imaging. CUDI aims at localizing prostate cancer by detection of angiogenesis, i.e., the development of a chaotic dense microvascular network that has a proven correlation with prostate cancer aggressiveness. Key features of the microvascular structure, such as microvascular density and tortuosity, are characterized by the dispersion of ultrasound contrast agents (microbubbles) through the microcirculation.\nA twofold validation of CUDI is performed. The ability of CUDI to differentiate between different microvascular structures is evaluated in an animal study using two xenograft models of human prostate cancer that feature different microvascular structures. Furthermore, a preliminary clinical validation is performed to evaluate the value of CUDI for prostate cancer localization in humans.