gebhart/patrepeval huggingface dataset:
Seroma Formation in Rat Latissimus Dorsi Resection in the Presence of Biologics (2014)

This study confirms a reliable rat model of seroma formation, with most of the rats exhibiting at least subclinical seromas. There was no difference in seroma formation rate in the presence of biologic implants, and no differences in bursa character between implants. Mechanical fixation with quilting sutures decreased seroma rate significantly in all subgroups. All rats with seromas at necropsy had histological evidence of a bursa with no difference in appearance between groups.
Oligoclonal expansion of CTLs directed against a restricted number of dominant minor histocompatibility antigens in hemopoietic chimeras (1995)

To understand how T cells respond to allogeneic minor histocompatibility Ags (MiHAs), we studied the fate of Thy-1.1+ lymphocytes, as well as their TCR usage and functional activity, in irradiated LP (Thy-1.2+) recipients transplanted with a mixture of C57BL/6 (Thy-1.2+) hemopoietic progenitors supplemented with either low or high numbers of B6.PL lymphocytes (Thy-1.1+). Mice transplanted with low numbers of T cells experienced a dramatic expansion (> or = 10(5)-fold) of donor Thy-1.1+/CD8+ cells during the first 15 days post-transplant. Flow-cytometric analysis and sequencing of junctional nucleotide sequences showed that the nature of this expansion was oligoclonal and involved primarily one or a few clones using V beta 5.1 or V beta 8.1 TCR elements. Expanded T lymphocyte populations displayed MHC-restricted cytotoxicity for a restricted number of MiHAs, that were found in only two peaks following fractionation of LP MiHAs by reverse-phase HPLC. Expansion of donor T cells was limited to the spleen, and short-lived in these recipients that became healthy long-term chimeras without any signs of graft-vs-host disease (GVHD). In contrast, mice transplanted with high numbers of T cells (GVHD+) showed proliferation of Thy-1.1+ donor cells not only in the spleen, but also in the thymus, and recipients died rapidly of GVHD. These results show that: 1) in the MiHA-incompatible transplantation setting, lack of GVHD cannot be explained simply by the absence of antihost T cell responses, 2) GVHD+ recipients present a massive thymic infiltration by donor mature T lymphocytes, and 3) antihost T cell responses are oligoclonal in nature and targeted to only a few MiHAs. These findings shed new light on the pathogenetic mechanisms involved in GVHD and on the selection of the T cell repertoire involved in response to immunodominant MiHAs.
Concerted evolution of duplicated protein-coding genes (2016)

Very rapid rates of gene conversion were observed between duplicated a-amylase-coding sequences in Drosophila melanogaster. This gene conversion process was also seen in the related species Drosophila erecta. Specifically, there is virtual sequence identity between the coding regions of the two genes within each species, while the sequence divergence between species is close to that expected based on their phy- logenetic relationship. The flanking, noncoding regions are much more highly diverged and do not appear to be subject to gene conversion. Comparison of amylase sequences between the two species provides a clear demonstration that recurrent gene conversion does indeed lead to the concerted evolution of the gene pair.
Multimodal Thromboprophylaxis for Total Hip and Knee Arthroplasty Based on Risk Assessment (2007)

A multimodal thromboembolic prophylactic regimen is consistent with protecting patients while limiting adverse clinical outcomes secondary to thromboembolic, vascular, and bleeding complications.
The CNS‐MAP‐Controller hypothesis: A new mathematical model for long‐term control of mean arterial pressure (MAP) (2008)

We present a new mathematical model in which the long‐term control of MAP is dominated by the central nervous system (CNS). The circulation is modeled as 2 parallel vascular beds; “renal” and “non‐renal”. The model assumes kidney function which fully adapts to chronic changes in MAP. The output of the “CNS‐MAP Controller” regulates sympathetic nerve activity (SNA) to renal and non‐renal arteriolar resistances and venous unstressed volume. Currently, the excitatory drive of the CNS‐MAP‐Controller consists of a synergistic interaction of circulating mineralocorticoids and plasma sodium. The model does not include primary renal dysfunction or “whole body autoregulation” as proposed in the Guyton‐Coleman model. Also, in contrast to the Guyton‐Coleman model in which one hemodynamic profile is proposed to underlie all forms of hypertension, our model suggests that several hemodynamic profiles associated with increased SNA are possible with either no change or decreased total blood volume. These hemodynamic profiles are consistent with published hemodynamic studies in experimental and human essential hypertension. This model supports the hypothesis that dysregulation in the brain, rather than kidney, can be responsible for the pathogenesis of hypertension. Supported by NIH Grant HL064178
Application of Substituted 2‐(Trimethylsilyl)ethyl Esters to Suppress Diketopiperazine Formation (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Thermal fluctuation of magnetization and random telegraph noise in magnetoresistive nanostructures (2006)

The thermally activated magnetization reversals in magnetic nanodevices have been theoretically investigated. This kind of thermal fluctuations is found to be the dominant cause of intrinsic write error in magnetoresistive random access memory elements, on which our study is aimed. Calculations are performed in the Stoner–Wohlfarth model assuming a single-domain free layer magnetization. The thermal fluctuations as a form of random telegraph noise in output voltage level are systematically characterized in both the time and frequency domains. The relationship of the thermal fluctuations with the free layer magnetic property, temperature and external magnetic field has been established.
Fabrication of disconnected three-dimensional silver nanostructures in a polymer matrix (2012)

We present a simple, one-step technique for direct-writing of a structured nanocomposite material with disconnected silver nanostructures in a polymer matrix. A nonlinear optical interaction between femtosecond laser pulses and a composite material creates silver structures that are embedded inside a polymer with submicrometer resolution (300 nm). We create complex patterns of silver nanostructures in three dimensions. The key to the process is the chemical composition of the sample that provides both a support matrix and controlled growth. The technique presented in this letter may offer a cost-effective approach for the fabrication of bulk optical devices with engineered dispersion.
Qualité de l'eau par télédétection hyperspectrale aéroportée : Application au fleuve Saint-Laurent (1994)

Le spectromètre imageur CASI (Compact Airborne Spectrographic Imager) a survolé à basse (487 m) et à haute (3200 m) altitude trois sections transverses du fleuve Saint-Laurent à la hauteur de Trois-Rivières pour l'analyse de la qualité de l'eau. Les images ont été acquises en mode haute résolution spectrale entre 400 nm et 800 nm. Des mesures in situ au spectroradiomètre Spectron ont été effectuées le lendemain et deux semaines plus tard à dix stations réparties sur les sections survolées par le CASI. Ces mesures consistaient en des spectres de luminance ascendante au nadir au-dessus de la surface de l'eau, avec et sans tête flottante (pour l'élimination des effets de scintillement du ciel et du soleil), et en des mesures d'éclairement descendant (pour l'extraction de la réflectance au nadir). Des données atmosphériques optiques ont aussi été récoltées ces deux jours. Des mesures in situ de concentration de sédiments en suspension et de turbidité ont été acquises à ces dix stations. Nous avons comparé les spectres CASI, Spectron (avec et sans scintillement) et ceux d'un modèle de transfert radiatif en utilisant les données de qualité de l'eau. Les résultats obtenus montrent une bonne correspondance entre les spectres CASI et Spectron, mais ceux-ci diffèrent des spectres calculés avec le modèle. Des différences apparaissent au niveau de l'amplitude des réflectances mesurées et au niveau de la position du pic de forte diffusion due à la chlorophylle dans l'eau (à 640 nm). Les résultats sont discutés en fonction des différents facteurs qui influencent le modèle. Les images acquises aux deux altitudes ont permis de valider une méthode simple d'inversion de l'épaisseur optique des aérosols. Enfin, l'analyse des profils de luminance corrigés le long des transverses permet de caractériser les zones de végétation submergée et les zones de profondeur d'eau variable.
A porous silicon JFET gas sensor: Experimental and modeling (2008)

In this work, electrical measurements and modeling of an integrated porous silicon (PS) JFET (PSJFET) gas sensor are reported. The experimental I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DS</sub> -V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DS</sub> curves were measured for different V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">GS</sub> voltages, both in synthetic air and in presence of 300 ppb of NO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> . The modeling was carried out by taking both the PS layer and the FET structure into account. By best fitting the experimental data with the given model, a quantitative evaluation of the effect of NO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> on both the PS layer and the FET structure was performed. Firstly, an indirect estimation of the PS resistance values in air (R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">PS_AIR</sub> ~31 kOmega) and in NO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> (R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">PS_NO2</sub> ~3.2 kOmega) was achieved, in agreement with data reported in literature and acquired by direct electrical measurements on PS. Moreover, it was also estimated that exposure to 300 ppb of NO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> resulted in a reduction of the FET channel section of ~0.2 mum, with respect to air.
Improving the accuracy and robustness of carotid-femoral pulse wave velocity measurement using a simplified tube-load model (2022)

Arterial stiffness, as measured by pulse wave velocity, for the early non-invasive screening of cardiovascular disease is becoming ever more widely used and is an independent prognostic indicator for a variety of pathologies including arteriosclerosis. Carotid-femoral pulse wave velocity (cfPWV) is regarded as the gold standard for aortic stiffness. Existing algorithms for cfPWV estimation have been shown to have good repeatability and accuracy, however, further assessment is needed, especially when signal quality is compromised. We propose a method for calculating cfPWV based on a simplified tube-load model, which allows for the propagation and reflection of the pulse wave. In-vivo cfPWV measurements from 57 subjects and numerical cfPWV data based on a one-dimensional model were used to assess the method and its performance was compared to three other existing approaches (waveform matching, intersecting tangent, and cross-correlation). The cfPWV calculated using the simplified tube-load model had better repeatability than the other methods (Intra-group Correlation Coefficient, ICC = 0.985). The model was also more accurate than other methods (deviation, 0.13 ms<sup>-1</sup>) and was more robust when dealing with noisy signals. We conclude that the determination of cfPWV based on the proposed model can accurately and robustly evaluate arterial stiffness.
Figure S6 from Arginine Depletion Therapy with ADI-PEG20 Limits Tumor Growth in Argininosuccinate Synthase–Deficient Ovarian Cancer, Including Small-Cell Carcinoma of the Ovary, Hypercalcemic Type (2023)

&lt;p&gt;IC50 curves for ADI-PEG20 in ovarian cancer cell lines. A, ASS1-deficient ovarian cancer cell lines and B, ASS1-proficient ovarian cancer cell lines.&lt;/p&gt;
Sol–gel–xerogel evolution investigated by electroactive probes in silica and transition-metal oxide based gels (1992)

Electrochemical techniques, including chronoamperometry, have been used to explore the evolution of composition and structure of silica and transition-metal gels prepared by sol–gel processes. Electroactive probes have been either freely dissolved into the gels or attached to the polymeric and oligomeric species. Their diffusion kinetics have been analysed in relation to parameters such as the gelation catalyst, the gel aging and drying. The results confirm predictions made by other techniques and shed new light on the behaviour of such systems.
Arrays of Parallel Connected Coaxial Multiwall‐Carbon‐ Nanotube–Amorphous‐Silicon Solar Cells (2009)

Arrays of parallel connected coaxial multiwall-carbon-nanotube–amorphous-silicon solar cells are fabricated. In this configuration, orthogonalization of the directions of light absorption and charge-carrier collection is realized. Under simulated solar illumination (AM 1.5 G), the short-circuit current of our carbon-nanotube enhanced solar cell is ∼25% higher than that of the planar cell.
Nanopore native RNA sequencing of a human poly(A) transcriptome (2018)

ABSTRACT High throughput cDNA sequencing technologies have dramatically advanced our understanding of transcriptome complexity and regulation. However, these methods lose information contained in biological RNA because the copied reads are often short and because modifications are not carried forward in cDNA. We address these limitations using a native poly(A) RNA sequencing strategy developed by Oxford Nanopore Technologies (ONT). Our study focused on poly(A) RNA from the human cell line GM12878, generating 9.9 million aligned sequence reads. These native RNA reads had an aligned N50 length of 1294 bases, and a maximum aligned length of over 21,000 bases. A total of 78,199 high-confidence isoforms were identified by combining long nanopore reads with short higher accuracy Illumina reads. We describe strategies for assessing 3′ poly(A) tail length, base modifications and transcript haplotypes from nanopore RNA data. Together, these nanopore-based techniques are poised to deliver new insights into RNA biology. DISCLOSURES MA holds shares in Oxford Nanopore Technologies (ONT). MA is a paid consultant to ONT. REW, WT, TG, JRT, JQ, NJL, JTS, NS, AB, MA, HEO, MJ, and ML received reimbursement for travel, accommodation and conference fees to speak at events organised by ONT. NL has received an honorarium to speak at an ONT company meeting. WT has two patents (8,748,091 and 8,394,584) licensed to Oxford Nanopore. JTS, ML and MA received research funding from ONT.
A Framework for Biobank Sustainability (2014)

Each year funding agencies and academic institutions spend millions of dollars and euros on biobanking. All funding providers assume that after initial investments biobanks should be able to operate sustainably. However the topic of sustainability is challenging for the discipline of biobanking for several major reasons: the diversity in the biobanking landscape, the different purposes of biobanks, the fact that biobanks are dissimilar to other research infrastructures and the absence of universally understood or applicable value metrics for funders and other stakeholders. In this article our aim is to delineate a framework to allow more effective discussion and action around approaches for improving biobank sustainability. The term sustainability is often used to mean fiscally self-sustaining, but this restricted definition is not sufficient for biobanking. Instead we propose that biobank sustainability should be considered within a framework of three dimensions - financial, operational, and social. In each dimension, areas of focus or elements are identified that may allow different types of biobanks to distinguish and evaluate the relevance, likelihood, and impact of each element, as well as the risks to the biobank of failure to address them. Examples of practical solutions, tools and strategies to address biobank sustainability are also discussed.
Current collapse in high-Al channel AlGaN HFETs (2019)

We report the first study of current collapse in ultra-wide bandgap high-Al AlGaN channel heterostructure field-effect transistors (HFETs) using short-pulse biasing. Our results show that, under applied pulsed gate and drain voltages, the current collapse results from increased resistance of the source- gate and gate-drain regions but not from the channel under the gate. We also show that passivation of access regions of the high-Al channel HFET with SiNx results in significant reduction in current collapse.
Comparing the Device Physics and Morphology of Polymer Solar Cells Employing Fullerenes and Non‐Fullerene Acceptors (2014)

There is a need to find electron acceptors for organic photovoltaics that are not based on fullerene derivatives since fullerenes have a small band gap that limits the open‐circuit voltage ( V OC ), do not absorb strongly and are expensive. Here, a phenylimide‐based acceptor molecule, 4,7‐bis(4‐(N‐hexyl‐phthalimide)vinyl)benzo[c]1,2,5‐thiadiazole (HPI‐BT), that can be used to make solar cells with V OC values up to 1.11 V and power conversion efficiencies up to 3.7% with two thiophene polymers is demonstrated. An internal quantum efficiency of 56%, compared to 75–90% for polymer‐fullerene devices, results from less efficient separation of geminate charge pairs. While favorable energetic offsets in the polymer‐fullerene devices due to the formation of a disordered mixed phase are thought to improve charge separation, the low miscibility (&lt;5 wt%) of HPI‐BT in polymers is hypothesized to prevent the mixed phase and energetic offsets from forming, thus reducing the driving force for charges to separate into the pure donor and acceptor phases where they can be collected.
Special Section Guest Editorial: Video Surveillance and Transportation Imaging (2013)

The present special section on Video Surveillance and Transportation Imaging was motivated by ubiquity of video surveillance in our everyday environment and transportation venues. With the advent of low-cost/high-performance video sensors, imaging platforms, and computational equipment, it has become increasingly possible to process video streams in real-time on affordable cloud computational servers, desktop systems, and various hand-held mobile devices. Major applications of these technologies span the spectrum from surveillance, transportation, remote sensing, social media, sports, retail, and biomedical to name a few.
Design and Fabrication of Cantilever for Scanning Magnetoresistance Microscope. (2000)

A variety of techniques have been proposed to measure surface magnetic properties using scanning probe microscopy. The most widely used is magnetic force microscopy (MFM). In many cases, however, it is hard to analyze MFM data quantitatively. A magnetoresistive (MR) device is also a candidate for such a sensor that can operate at room temperature with high sensitivity. Yamamoto et al. have demonstrated a scanning magnetoresistance microscope (SMRM) using a commercially available MR read-head for a hard disk. Since they held the MR head on a slider, there was no feedback system to control the distance between sample and sensor. We made a cantilever for the MR sensor to get the surface topography and magnetic properties simultaneously. Its magnetic field sensitivity with 10-mA sensing current is 90 μV/Oe, and our roughly estimated minimum field resolution is a few mOe (only Johnson noise is assumed with 10-kHz bandwidth at room temperature), which is much better than that of a scanning Hall probe microscope.
ChemInform Abstract: Radical Addition to Strained Olefins: A Flexible Access to Small Ring Derivatives. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Data from H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma (2023)

&lt;div&gt;Abstract&lt;p&gt;Activation of the fibroblast growth factor receptor FGFR4 by FGF19 drives hepatocellular carcinoma (HCC), a disease with few, if any, effective treatment options. While a number of pan-FGFR inhibitors are being clinically evaluated, their application to FGF19-driven HCC may be limited by dose-limiting toxicities mediated by FGFR1–3 receptors. To evade the potential limitations of pan-FGFR inhibitors, we generated H3B-6527, a highly selective covalent FGFR4 inhibitor, through structure-guided drug design. Studies in a panel of 40 HCC cell lines and 30 HCC PDX models showed that FGF19 expression is a predictive biomarker for H3B-6527 response. Moreover, coadministration of the CDK4/6 inhibitor palbociclib in combination with H3B-6527 could effectively trigger tumor regression in a xenograft model of HCC. Overall, our results offer preclinical proof of concept for H3B-6527 as a candidate therapeutic agent for HCC cases that exhibit increased expression of FGF19. &lt;i&gt;Cancer Res; 77(24); 6999–7013. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Developmental alterations in casein kinase 2 activity during the morphogenesis of quail secondary palate (1997)

On the basis of literature analysis and the results of the present study, it was suggested that the activity of CK 2 may be regulated along with protein kinase A to coordinate cell proliferation and the synthesis of extracellular matrices during palate development in quail.
Effects of head field and AC field on magnetization reversal for microwave assisted magnetic recording (2017)

Microwave assisted magnetic recording (MAMR) is a promising recording method for achieving high recording densities in hard disk drives. In MAMR, the AC field from a spin-torque oscillator (STO) assists the head field with magnetization reversal in a medium. Therefore, the relationship between the head field and the AC field is very important. In this study, the effects of the head field and the AC field on magnetization reversal were analyzed using a micromagnetic simulator that takes the magnetic interactions between a single-pole type (SPT) write-head, an exchange coupled composite (ECC) medium, and the STO into account. As a result, the magnetization reversal was assisted not just by the y-component of the AC field (Hstoy) but also by the y-component of the head field (Hhy) in the medium. The Hhy over 100 kA/m with a frequency of about 15.5 GHz induced the magnetic resonance. The large Hhy was produced by the field from the STO to the SPT head.