gebhart/patrepeval huggingface dataset:
2′,5′-Dihydroxyflavone and its 5′-Acetate — Novel Compounds from the Farinose Exudate of Primula (1988)

2′,5′-Dihydroxyflavone and its 5′-acetate were isolated from the farinose exudate of Primula japonica and P. pulverulenta. Their structures were elucidated by spectroscopic methods and confirmed by synthesis. Both flavones are novel natural products.
Biochemical sensor based on a resonant microcavity (2007)

Monoclonal antibodies, which recognize a single binding site on their target antigen, were used to sensitize the surface of ultra-high Q resonators. Experiments verifying the sensitivity and specificity of the microcavities were performed.
Synthesis and properties of waterborne polyurethane adhesives: effect of chain extender of ethylene diamine, butanediol, and fluoro-butanediol (2013)

Abstract Waterborne polyurethane (WBPU) adhesives were prepared using poly(tetramethylene oxide glycol), 4,4’-dicyclohexylmethane diisocyanate (H12MDI), hydrophilic agent dimethylol propionic acid and chain extender of 2,2,3,3-tetrafluoro-1,4-butanediol (TFBD), ethylene diamine (EDA), and 1,4-butanediol. All three chain extenders have been used as single and mixed (different ratio) content during synthesis, and the effect of chain extender and their content to the properties of tensile strength, Young’s modulus, water swelling (%), and adhesive strength was investigated. The adhesive strength value was higher using EDA as a single-chain extender; however, the potentiality of adhesive strength under water was improved using mixed-chain extenders of EDA and TFBD in WBPU adhesives. The maxima potentiality was observed with 6.31 mole% TFBD and 2.10 mole% EDA in WBPU adhesives. Keywords: polyurethaneschain extenderadhesive strengthtensile strength Acknowledgments This study was supported by Center of Research Excellence in Corrosion (CoRE-C), King Fahd University of Petroleum and Minerals (KFUPM) in the 2012 Summer Assignment program.
Prostate Cancer Transcriptomic Regulation by the Interplay of Germline Risk Alleles, Somatic Mutations, and 3D Genomic Architecture (2022)

Many prostate cancer germline risk alleles are enriched in the noncoding regions of the genome and are hypothesized to regulate transcription. We present a 3D genomics framework to unravel risk SNP function and describe the widespread germline-somatic interplay in transcription control. This article is highlighted in the In This Issue feature, p. 2711.
Reactivity of monoclonal anti‐melanoma antibodies with melanoma cells freshly isolated from primary and metastatic melanoma (1979)

Human melanoma cells, freshly obtained from nine primary and metastatic melanoma cases, were tested for binding of monoclonal anti-melanoma antibodies produced in vitro by hybridoma clones. Monoclonal anti-melanoma antibodies bind to melanoma cells but do not react with nonmalignant cells obtained from the same patients or with cells obtained from giant hairy nevus. These results confirm the existence of tumor-specific antigens. Binding of monoclonal antibodies to melanoma cells of several origins, primary or metastatic, from different patients suggests the existence of tumor antigens shared by human melanoma cells. The binding pattern of different antibodies to various cells also predicts the existence of more than one tumor-specific antigenic determinant on melanoma cells.
Verticillium rexianum (SACC.) SACC., a New Producer of Monacolin K (1998)

Abstract From the broth of submerged cultures of Verticillium rexianum (teleomorph: Nectriopsis exigua), a mycophilic fungus growing on myxomycetes, monacolin K was iso­lated as a weak inhibitor of pectate lyase. Monacolin K is the first secondary metabolite described from V. rexianum.
DC analysis technique for inductive power transfer pick-ups (2003)

Inductively coupled power transfer (ICPT) systems are now being used in applications where their efficiency and stability are critically important. In this paper, an ICPT pick-up is analyzed under conditions where the pick-up tuning is assumed to be essentially perfect, and all diodes are assumed to have continuous current flow in them. The analysis proceeds by replacing the existing parallel resonant tank and rectifier circuit with a DC source and transformer equivalent, thereby reducing the complexity of the circuit, and eliminating the diodes. The DC equivalent is shown to have the same energy storage and power capability as the original circuit and is accurate under all loadings for both transient and steady-state conditions. With this simplification, analytic transfer functions for the pick-up with respect to its excitation current and its control switch duty cycle are developed. The ICPT system model is shown to have multiple poles, with complex zeroes on the right half plane. The model allows a sophisticated controller to be designed to give the ICPT system the required stability at high efficiency.
Field Application Results of Water Permeability Modifier in Fracture Stimulation Treatments in Western Siberia (2012)

Abstract Historically, hydraulic-fracture stimulation of zone zones with directly underlying waters has not been considered a practical method for improved oil recovery. This was because the stimulation treatment could result in water cuts from 90-100%. Many of the oil and gas reservoirs in Western Siberia have production zones that fall into this scenario. The zones contain high-permeability streaks of mobile water and have water bearing layers above and/or below the producing zone. When a hydraulic-fracturing treatment is performed on such production zones, unintentional stimulation of the adjacent water bearing layers occurs. As a result, high water production is observed from the high permeability streaks of water or the adjacent water-bearing layers. Over a period of time, those wells will continue to lose hydrocarbon production rate, while the water cut continues to increase. Water separation and disposal of the produced water is expensive and not always successful. Using recent water permeability modifier (WPM) chemistry advances, the hydraulic-fracture stimulation of such zones has now been shown to be an effective way to stimulate and produce the mature oil and gas fields such as those found in Western Siberia. The incorporation of a water permeability modifier with a hydrophobic backbone containing hydrophilic branches with the hydraulic fracture stimulation has proven to be very effective in obtaining oil production above what was anticipated based upon comparison with offset wells fracture stimulated without the WPM. It was further observed that not only was the produced water rate typically less than previously observed, but that it continues to decline over time instead of increasing. This paper presents the results of the implementation and analysis of 11 WPM fracture-stimulation treatments that were performed in a field in Western Siberia in 2009. Discussed will be the WPM technology, treatment design, post production analysis, and recommendation selection of candidates and successful implementation of the WPM technology in the western Siberian fields.
Unterschiedliche Beteiligung opioiderger und noradrenerger Mechanismen an der antinozizeptiven und antiallodynischen Wirksamkeit von Tapentadol in Rattenmodellen nozizeptiver und neuropathischer Schmerzen (2010)

Hintergrund: Die Aktivierung des µ-Opioidrezeptors (MOR) und die Hemmung der Noradrenalin (NA)-Wiederaufnahme (WA) sind anerkannte analgetische Prinzipien bei akuten und chronischen Schmerzzuständen. Das neuartige Analgetikum Tapentadol (TAP) kombiniert MOR-Agonismus und NA-WA-Hemmung in einem einzigen Molekül und zeigt in verschiedenen Schmerzmodellen an Nagetieren eine potente analgetische Wirkung. Diese Studie untersuchte die Beteiligung opioiderger und monoaminerger Mechanismen an der Aktivität von TAP in Rattenmodellen nozizeptiver und neuropathischer Schmerzen.
Two-year follow-up of KTE-X19, an anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, in adult patients (Pts) with relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL) in ZUMA-3. (2022)

7010 Background: Brexucabtagene autoleucel (KTE-X19) is an autologous anti-CD19 CAR T-cell therapy approved in the US to treat adult R/R B-ALL based on the ZUMA-3 study. The overall complete remission (CR) rate (CR + CR with incomplete hematologic recovery [CRi]) was 71% (95% CI, 57-82) after 16.4 mo median follow-up (N = 55; Shah et al. Lancet 2021). Here, we report updated outcomes with longer follow-up in these pts and in a larger pooled analysis of Phase (Ph) 1 and 2 pts who received the pivotal dose of KTE-X19. Methods: Eligible adults (≥18 years) had R/R B-ALL and received a single infusion of KTE-X19 at the pivotal dose (1×10 6 CAR T cells/kg) following leukapheresis and conditioning chemotherapy. The primary endpoint was CR/CRi rate by central review. Results: As of 23 July 2021, median follow-up was 26.8 mo (range, 20.7-32.6) for treated Ph 2 pts (N = 55). The CR/CRi rate per central review was 71% (95% CI, 57-82; 56% CR; 15% CRi). Eleven pts (20%; 8 CR and 2 CRi) proceeded to subsequent allogeneic stem cell transplant (alloSCT). Median duration of remission (DOR) censored at subsequent alloSCT was 14.6 mo (9.4-not estimable [NE]); not censored: 18.6 mo (9.6-NE); 6/39 responders (15%) had ongoing responses at data cutoff. Median (95% CI) relapse-free survival (RFS) was 11.6 mo (2.7-20.5) censored at subsequent alloSCT and 11.7 mo (2.8-20.5) not censored at subsequent alloSCT; 18-mo RFS rates (95% CI) were 35% (20.5-50.6) and 42% (28.0-55.0), respectively. Median (95% CI) overall survival (OS) was 25.4 mo (16.2-NE) among all KTE-X19-treated pts and not reached (25.4-NE) in pts with CR (n = 31). For Ph 1/2 pts (N = 78) who received the pivotal KTE-X19 dose (median follow-up: 29.7 mo; range 20.7-58.3), the CR/CRi rate by independent review was 73% (95% CI, 62-82). Medians (95% CI) for DOR, RFS, and OS were 18.6 mo (9.6-NE), 11.7 mo (6.1-20.5), and 25.4 mo (16.2-NE), respectively. A subgroup analysis revealed that in pts aged 18-39 (n = 36), 40-59 (n = 27), and ≥60 (n = 15) years, the CR/CRi rates (95% CI) were 69% (52-84), 70% (50-86), and 87% (60-98); 24-mo OS rates (95% CI) were 48% (30-64), 54% (33-71), and 57% (28-78), respectively. In pts with pre-KTE-X19 infusion marrow blast percentages &gt; 25 to ≤50 (n = 12), &gt; 50 to ≤75 (n = 14), and &gt; 75 to 100 (n = 30), CR/CRi rates (95% CI) were 83% (52-98), 86% (57-98), and 57% (37-75); 24-mo OS rates (95% CI) were 58% (27-80), 55% (26-77) and 37% (19-55), respectively. There were no new safety signals; the proportion of treated Ph 2 pts with Gr ≥3 treatment emergent adverse events was unchanged since prior data cutoff. One pt had an ongoing neurologic event of Gr 1 finger numbness. Conclusions: With longer follow-up and an expanded data set by independent review, outcomes remain durable in adults with R/R B-ALL, most of whom were heavily pretreated, with median OS not yet reached in pts with CR. Long-term safety was favorable. Clinical trial information: NCT02614066.
Faculty Opinions recommendation of Evolved orthogonal ribosome purification for in vitro characterization. (2010)

We developed orthogonal ribosome-mRNA pairs in which the orthogonal ribosome (O-ribosome) specifically translates the orthogonal mRNA and the orthogonal mRNA is not a substrate for cellular ribosomes. O-ribosomes have been used to create new cellular circuits to control gene expression in new ways, they have been used to provide new information about the ribosome, and they form a crucial part of foundational technologies for genetic code expansion and encoded and evolvable polymer synthesis in cells. The production of O-ribosomes in the cell makes it challenging to study the properties of O-ribosomes in vitro, because no method exists to purify functional O-ribosomes from cellular ribosomes and other cellular components. Here we present a method for the affinity purification of O-ribosomes, via tagging of the orthogonal 16S ribosomal RNA. We demonstrate that the purified O-ribosomes are pure by primer extension assays, and structurally homogenous by gel electrophoresis and sucrose gradients. We demonstrate the utility of this purification method by providing a preliminary in vitro characterization of Ribo-X, an O-ribosome previously evolved for enhanced unnatural amino acid incorporation in response to amber codons. Our data suggest that the basis of Ribo-X's in vivo activity is a decreased affinity for RF1. PMID: 20185573 Funding information This work was supported by: Medical Research Council, United Kingdom Medical Research Council, United Kingdom Grant ID: MRC_MC_UP_A024_1008 Medical Research Council, United Kingdom Grant ID: MRC_MC_U105181009
Cognitive Radio Prototyping (2008)

Future wireless systems have been evolving toward a broadband and open architecture for efficient multi-service operation, which will have a great impact on the terminal and infrastructure component design methodology for supporting multiple radio schemes. Cooperation in wireless networks, requiring cognitive radio implementations, will facilitate a new dimension in the evolution of multimedia communications. The growing price pressure requires ever increasing high levels of integration efficiency, of flexibility and of future proofness at the same time, setting out in the digital baseband domain. In this communication, the authors will illustrate a platform based prototyping process, setting out from the paradigm developed in the IST-27960 STREP URANUS (UNIVERSAL RADIO-LINK PLATFORM FOR EFFICIENT USER-CENTRIC ACCESS). URANUS investigates the design of a universal radio link platform able to be incorporated in any existing proprietary and standardized wireless system in a seamless way, to ease the introduction of future personalized communications and reconfigurable air interfaces.
Biochemical characterization and mutational studies of a chalcone synthase from yellow snapdragon (Antirrhinum majus) flowers (2006)

The 4′-O-glucosides of 2′,4,4′,6′-tetrahydroxychalcone (THC) and 2′,3,4,4′,6′-pentahydroxychalcone (PHC) are present in the yellow snapdragon (Antirrhinum majus) flowers and serve as direct precursors for the synthesis of aurones, the yellow pigments of the flowers. Despite the metabolic significance of these chalcones in aurone biosynthesis, the biochemical properties of chalcone synthase (CHS), the enzyme responsible for their synthesis, remains to be clarified. In this study, one known CHS cDNA (niv, also termed AmCHS1) and one CHS-related cDNA, AmCHS2, were isolated from yellow snapdragon buds. AmCHS1 mRNA specifically accumulated in the petals in a coloration-dependent manner, whereas AmCHS2 mRNA accumulated only negligibly in petals and other organs, corroborating the importance of AmCHS1 in chalcone synthesis in the yellow flower. Recombinant AmCHS1 that was heterologously expressed in Escherichia coli cells efficiently utilized both p-coumaroyl-CoA and caffeoyl-CoA (relative activity, 50% of the activity for p-coumaroyl-CoA) as a starting ester to produce THC and PHC, respectively. Previous studies predicted that a single Thr197Ala or the double Val196Met/Thr197Ala substitution in AmCHS1 may provide a wider space for hydroxycinnamoyl-group binding and might enhance the ability of this enzyme to produce PHC [Austin MB, Noel JP (2003) Nat Prod Rep 20: 79–110]. However, these substitutions led to a decreased PHC-producing activity, implying that other factors may also be important for the efficient utilization of caffeoyl-CoA.
An energy-conscious transport protocol for multi-hop wireless networks (2007)

We present a transport protocol whose goal is to reduce power consumption without compromising delivery requirements of applications. To meet its goal of energy efficiency, our transport protocol (1) contains mechanisms to balance end-to-end vs. local retransmissions; (2) minimizes acknowledgment traffic using receiver regulated rate-based flow control combined with selected acknowledgements and in-network caching of packets; and (3) aggressively seeks to avoid any congestion-based packet loss. Within a recently developed ultra low-power multi-hop wireless network system, extensive simulations and experimental results demonstrate that our transport protocol meets its goal of preserving the energy efficiency of the underlying network.
Realisasi Tindak Tutur Kkomisif pada Penggunaan Bahasa di Kalangan Pedagang Pasar Tradisional Kleco Kartasura (2021)

The research objectives were to 1) describe the types of commissive acts on the use&#13;\nof language among Kleco Traditional Market traders. 2) Describe the form of&#13;\ncommissive politeness in the use of language among Kleco Traditional Market&#13;\ntraders and 3) Describe buyers' perceptions of the use of politeness in language&#13;\namong Kleco Traditional Market traders. This research is a descriptive qualitative&#13;\nresearch. The data used in this study are the realization of the act of commissive&#13;\npoliteness in the use of language among Kleco Traditional Market traders. Sources&#13;\nof data in this study are traders and buyers when making buying and selling&#13;\ntransactions among Kleco Traditional Market traders. The data collection&#13;\ntechniques in this study also used record and note techniques as well as interviews,&#13;\nwhile the data validity study technique in this study used data triangulation. Then the&#13;\ndata analysis techniques in this study were data reduction, data presentation, and&#13;\ndrawing conclusions / verification. The results of this study indicate that 1) Based on&#13;\nthe results of the study, it is known that the types of commissive speech acts found in&#13;\nthe use of language among Kleco Kartasura Traditional Market traders are 10&#13;\nspeech acts including 5 promising commissive speech acts, 3 swearing commissive&#13;\nspeech acts, and 2 speech acts. commissive threatening. So it can be concluded that&#13;\nthe most common form of commissive speech act is the promise of commissive speech&#13;\nact. 2) The form of commissive politeness in the use of language among Kleco&#13;\ntraditional market traders, Kartasura found as many as 12 maxims which include 2&#13;\nwisdom maxims, 2 acceptance maxims, 4 generosity maxims, 1 humility maxims, and&#13;\n3 agreement maxims. 3) Based on the results of the interview, it is known that most&#13;\ntraders use polite language towards buyers who are shopping&#13;\n&#13;\nKeywords:Realization, commissive speech acts, traders
Deep traps in In0.3Ga0.7As nFinFETs studied by Generation-Recombination noise (2017)

The assessment of deep traps in In <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.3</inf> Ga <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.7</inf> As nFinFETs by Generation-Recombination (GR) noise spectroscopy is described in this paper. The gate voltage dependence of the corner frequency is studied for several devices with different gate lengths. Both gate-voltage-independent and gate-voltage-dependent corner frequencies are found. It is shown that the noise type turns from GR to Random Telegraph Signal (RTS) when the device size scales. For GR noise, the activation energy of the traps is extracted, which can tentatively be attributed to O-related traps and dislocations, with an effective density of these deep levels varying from 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sup> /cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</sup> /cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . For RTS, the capture and emission time constant are extracted. It could be ascribed to a single trap in the gate oxide rather than in the film, and it is concluded that the trap level is lower than the Fermi level when no bias is applied.
ChemInform Abstract: Tris(2‐(perfluorohexyl)ethyl)tin Hydride: A New Fluorous Reagent for Use in Traditional Organic Synthesis and Liquid Phase Combinatorial Synthesis. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Advanced Single-Polymer Nanofiber-Reinforced Composite - Towards Next Generation Ultralight Superstrong/Tough Structural Material (2015)

Abstract : The goals of this research were to establish feasibility of manufacturing and to evaluate performance of novel continuous polyimide nanofibers and their nanocomposites. The specific objectives were: (1) demonstrate feasibility of fabrication of continuous nanofibers from a range of specially synthesized soluble polyimides; (2) characterize their mechanical behavior and properties; and (3) fabricate and characterize polyimide nanofiber-reinforced composites. Continuous nanofibers were successfully manufactured from several specially designed polyimides and tested in the broad range of diameters. Significant simultaneous improvements in strength and toughness with the reduction of diameter were observed and analyzed. The best nanofibers were as strong as advanced conventional fibers while maintaining higher toughness. It was shown that chemical structure and processing control nanofiber properties and toughness. Polyimide nanofibers were also successfully incorporated into nanocomposites. It was demonstrated that continuous nanofibers may provide unique advantages for future structural nanocomposites.
Recent developments in metal laminated tooling by multiple laser processing (2003)

Time reduction and quick geometrical changes of complex components and tools are currently the most important demands in product development. The manufacturing process presented in this paper is based on multiple additive and subtractive technologies such as laser cutting, laser welding, direct laser metal deposition and CNC milling. The process chain is similar to layer‐based Rapid Prototyping Techniques. In the first step, the 3D CAD geometry is sliced into layers by a specially developed software. These slices are cut by high speed laser cutting and then joined together. In this way laminated tools or parts are built. To improve surface quality and to increase wear resistance a CNC machining center is used. The system consists of a CNC milling machine, in which a 3 kW Nd:YAG laser, a coaxial powder nozzle and a digitizing system are integrated.
Carrier-suppressed microwave fiber-optic source using intracavity modulation (2005)

Summary form only given. We demonstrate a carrier suppressed source that reduces the problem of relative drift between the carrier and filter wavelengths. The source consists of a ring laser cavity with an intracavity optical modulator and a frequency selective output coupler (FSOC). The FSOC transmits light at a frequency /spl omega//sub 0/ and couples light out of the cavity for frequencies outside of the narrow passband centered around /spl omega//sub 0/. When this optical signal is demodulated by a photodetector, the DC electrical power is reduced more than the RF power. Hence, optical amplification to the maximum photodetector DC power results in a net RF gain as compared to the case with the same DC power without carrier suppression. An advantage of this system is that the carrier field is passively locked to the frequency that is maximally transmitted through the FSOC.