gebhart/patrepeval huggingface dataset:
Synthesis of dl-myo-inositol 1,4,5-trisphosphate (1987)

Conference Article| October 01 1987 Synthesis of dl-myo-inositol 1,4,5-trisphosphate ALLAN M. COOKE; ALLAN M. COOKE *Department of Chemistry, Leicester University, Leicester LE1 7RH, U.K. Search for other works by this author on: This Site PubMed Google Scholar ROY GIGG; ROY GIGG †Laboratory of Lipid and General Chemistry, National institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, U.K. Search for other works by this author on: This Site PubMed Google Scholar BARRY V. L. POTTER BARRY V. L. POTTER ‡ *Department of Chemistry, Leicester University, Leicester LE1 7RH, U.K. ‡To whom correspondence should be addressed Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1987) 15 (5): 904–906. https://doi.org/10.1042/bst0150904 Article history Received: March 16 1987 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation ALLAN M. COOKE, ROY GIGG, BARRY V. L. POTTER; Synthesis of dl-myo-inositol 1,4,5-trisphosphate. Biochem Soc Trans 1 October 1987; 15 (5): 904–906. doi: https://doi.org/10.1042/bst0150904 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: IP3, d-myo-inositol 1,4,5-trisphosphate This content is only available as a PDF. © 1987 Biochemical Society1987 Article PDF first page preview Close Modal You do not currently have access to this content.
Optically Heralded Entanglement of Superconducting Systems in Quantum Networks (2021)

Networking superconducting quantum computers is a longstanding challenge in quantum science. The typical approach has been to cascade transducers: converting to optical frequencies at the transmitter and to microwave frequencies at the receiver. However, the small microwave-optical coupling and added noise have proven formidable obstacles. Instead, we propose optical networking via heralding end-to-end entanglement with one detected photon and teleportation. This new protocol can be implemented on standard transduction hardware while providing significant performance improvements over transduction. In contrast to cascaded direct transduction, our scheme absorbs the low optical-microwave coupling efficiency into the heralding step, thus breaking the rate-fidelity trade-off. Moreover, this technique unifies and simplifies entanglement generation between superconducting devices and other physical modalities in quantum networks.
Supplementary Figure S1 from Predictive Biomarkers for Adjuvant Capecitabine Benefit in Early-Stage Triple-Negative Breast Cancer in the FinXX Clinical Trial (2023)

&lt;p&gt;Supplementary Figure S1 shows a CONSORT diagram of the study cohort&lt;/p&gt;
Antitumor activity of peptide fraction from traditional Korean soy sauce (2004)

Antitumor activities of a peptide fraction isolated from traditional Korean soy sauce (SSP) were investigated in vitro and in vivo using cancer cell lines and F9 teratocarcinoma-bearing BALB/c mice. SSP exerted a dose-dependent antiproliferative effect on P388D1 mouse lymphoma, F9 mouse teratocarcinoma, and DLD-1 human colon cancer cells with IC 50 values of 11, 50, and 50 μg/ml, respectively. Tumor growth in F9 teratocarcinoma-bearing BALB/c mice, orally administered with 80 and 200 mg/kg/day of SSPs, was inhibited 10.3% and 52.4%, respectively, and survival days increased by 11.9% and 22.1%, respectively, compared to the control group. The results of antitumor activities exerted by SSP in vitro and in vivo suggest the feasibility of using SSP as an antitumor agent.
Data from Comprehensive Molecular Profiling of Olfactory Neuroblastoma Identifies Potentially Targetable <i>FGFR3</i> Amplifications (2023)

&lt;div&gt;Abstract&lt;p&gt;Olfactory neuroblastomas (ONBs), also known as esthesioneuroblastomas, are malignant round-cell tumors that represent up to 5% of sinonasal malignancies. Despite their aggressive course, molecular studies of ONBs have been limited, and targeted therapies are lacking. To identify potential oncogenic drivers and targetable pathways in ONBs, we characterized 20 ONBs, including archived ONBs profiled by targeted, multiplexed PCR (mxPCR)–based DNA next-generation sequencing (NGS) of the coding sequence of over 400 cancer-relevant genes (&lt;i&gt;n&lt;/i&gt; = 16), mxPCR-based RNA NGS of 108 target genes (&lt;i&gt;n&lt;/i&gt; = 15), and 2 ONBs profiled by comprehensive hybrid-capture–based clinical grade NGS of &gt;1,500 genes. Somatic mutations were infrequent in our cohort, with 7 prioritized nonsynonymous mutations in 5 of 18 (28%) ONBs, and no genes were recurrently mutated. We detected arm/chromosome-level copy-number alterations in all tumors, most frequently gains involving all or part of chromosome 20, chromosome 5, and chromosome 11. Recurrent focal amplifications, often but not exclusively in the context of arm-level gains, included &lt;i&gt;CCND1&lt;/i&gt; [&lt;i&gt;n&lt;/i&gt; = 4/18 (22%) tumors] and the targetable receptor tyrosine kinase &lt;i&gt;FGFR3&lt;/i&gt; [&lt;i&gt;n&lt;/i&gt; = 5/18 (28%) tumors]. Targeted RNA NGS confirmed high expression of &lt;i&gt;FGFR3&lt;/i&gt; in ONB (at levels equivalent to bladder cancer), with the highest expression observed in &lt;i&gt;FGFR3&lt;/i&gt;-amplified ONB cases. Importantly, our findings suggest that FGFR3 may be a therapeutic target in a subset of these aggressive tumors.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Implications:&lt;/b&gt; ONBs harbor recurrent chromosomal copy-number changes, including &lt;i&gt;FGFR3&lt;/i&gt; amplification associated with overexpression. Hence, FGFR3 may represent a novel therapeutic target in these tumors. &lt;i&gt;Mol Cancer Res; 15(11); 1551–7. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
THE EFFECTS OF DIASPIRIN CROSS-LINKED HEMOGLOBIN IN SEPSIS (1996)

We tested the hypothesis that diaspirin cross-linked hemoglobin (DCLHb; Baxter Healthcare Corp.) would improve blood pressure, organ perfusion, and mortality during sepsis. Rats were catheterized to assess general hemodynamics (protocol 1) or regional blood flow (protocol 2). Sepsis was induced by intraperitoneal introduction of a cecal slurry (100 mg/kg). In protocol 1, rats received either 100 or 250 mg/kg DCLHb, or albumin at 1, 2, or 4 h after sepsis induction. Hemodynamics were recorded at these times and daily for 72 h. DCLHb increased blood pressure, prevented 72 h leukocytosis, and reduced mortality, but the timing of DCLHb administration was crucial. In protocol 2 only moribund septic animals received 100 mg/kg DCLHb or iso-oncotic albumin i.v. Hemodynamics and regional organ blood flows were measured at baseline, immediately before and after treatment, and at 24 h. DCLHb immediately increased blood pressure with no changes in cardiac output, heart rate, or regional perfusion. DCLHb increased regional perfusion to vital areas at 24 h (compared to albumin group). Distribution of cardiac output in albumin-treated rats was significantly skewed toward skeletal muscle at a time when cardiac output was significantly lower as compared with DCLHb treated animals. In conclusion, DCLHb safely elicited a pressor response, and improved regional perfusion to selected tissues. However, DCLHb benefits were best obtained when given within a specific time frame.
Multimodality Molecular Imaging of Cardiac Cell Transplantation: Part II. In Vivo Imaging of Bone Marrow Stromal Cells in Swine with PET/CT and MR Imaging (2016)

Purpose To quantitatively determine the limit of detection of marrow stromal cells (MSC) after cardiac cell therapy (CCT) in swine by using clinical positron emission tomography (PET) reporter gene imaging and magnetic resonance (MR) imaging with cell prelabeling. Materials and Methods Animal studies were approved by the institutional administrative panel on laboratory animal care. Seven swine received 23 intracardiac cell injections that contained control MSC and cell mixtures of MSC expressing a multimodality triple fusion (TF) reporter gene (MSC-TF) and bearing superparamagnetic iron oxide nanoparticles (NP) (MSC-TF-NP) or NP alone. Clinical MR imaging and PET reporter gene molecular imaging were performed after intravenous injection of the radiotracer fluorine 18-radiolabeled 9-[4-fluoro-3-(hydroxyl methyl) butyl] guanine ((18)F-FHBG). Linear regression analysis of both MR imaging and PET data and nonlinear regression analysis of PET data were performed, accounting for multiple injections per animal. Results MR imaging showed a positive correlation between MSC-TF-NP cell number and dephasing (dark) signal (R(2) = 0.72, P = .0001) and a lower detection limit of at least approximately 1.5 × 10(7) cells. PET reporter gene imaging demonstrated a significant positive correlation between MSC-TF and target-to-background ratio with the linear model (R(2) = 0.88, P = .0001, root mean square error = 0.523) and the nonlinear model (R(2) = 0.99, P = .0001, root mean square error = 0.273) and a lower detection limit of 2.5 × 10(8) cells. Conclusion The authors quantitatively determined the limit of detection of MSC after CCT in swine by using clinical PET reporter gene imaging and clinical MR imaging with cell prelabeling. (©) RSNA, 2016 Online supplemental material is available for this article.
Towards a reliable and high-speed wireless complement to TTEthernet (2014)

TTEthernet is a general purpose communication infrastructure for applications with real-time and/or fault-tolerance requirements. It is based on Ethernet as standardized by the IEEE and allows the integration of mixed-criticality applications in a single physical network. However, currently TTEthernet only operates in wired network settings. With growing industrial demand of the design freedom that comes with wireless communication solutions we are interested in extending TTEthernet to a wireless communication paradigm. In this paper we review the state of the art in deterministic wireless communication approaches. We deduce quality criteria for wireless networks from industrial use cases and outline candidates for a wireless complement to wired TTEthernet.
An African swine fever virus gene with homology to DNA ligases (1992)

Sequence analysis of the SalI g region of the genome of a virulent isolate of ASFV (Malawi Lil 20/1) has revealed an open reading frame with the potential to encode a 48 kilodalton (kD) polypeptide which has significant homology with eukaryotic and prokaryotic DNA ligases. This ASFV encoded gene also contains the putative active site region of DNA ligases including the lysine residue which is necessary for enzyme-adenylate adduct formation, but lacks the C-terminal basic region conserved in other eukaryotic DNA ligases. A novel [32P]-labelled potential DNA ligase-adenylate adduct of M(r) 45 kD was observed upon incubation of ASFV infected cell cytoplasmic extracts with alpha-[32P]-ATP and subsequent analysis of products by SDS/PAGE. These data together suggest that ASFV encodes its own DNA ligase.
Effect of air breakdown with a focusing lens on ultrashort laser ablation (2011)

The effect of air breakdown on ultrashort laser ablation is investigated in this letter using an integrated simulation method on atomistic level. The generation of air breakdown with different laser peak power densities in the range from 1013 to 1016 W/cm2 and various focusing conditions is analyzed. Air breakdown is generated directly from laser energy absorption through avalanche ionization at a high power density (over 1014 W/cm2), while at a lower power density, air breakdown is assisted by a metal target near the focal region. The laser energy loss due to air breakdown and its effect on laser ablation are studied.
18O tracer studies of CO oxidation with O2on MoO3. Part 2.—Active sites for CO oxidation with O2and for oxygen isotope exchange between CO2and MoO3 (1994)

Oxygen isotope exchange between C 18O2 and MoO3 has been examined in connection with the catalytic oxidation of C 16O with 18O2 on MoO3. Oxide ions at mobile and immobile sites on MoO3, which oxidize CO in the catalytic oxidation, were found to work also as active sites in the oxygen isotope exchange between C 18O2 and Mo 16O3. The observed time dependences of the yields of C 18O2, C 18O 16O and C 16O2 in the exchange agreed satisfactorily with those calculated from the mobile and immobile site model. In the calculation, the number of immobile sites was estimated to be 1.8% of the total surface lattice oxide ions. The exchange rate at immobile sites was 13% of the total exchange rate.
Low-noise 650 nm-band AlGaInP visible lasers with highly-doped saturable absorbing (HDSA) layer (2002)

Self-sustained pulsating 650 nm-band AlGaInP visible laser diodes were successfully demonstrated by adopting novel structure, which has highly doped saturable absorbing layer. Short carrier lifetime, which is indispensable for pulsation, was realized by applying high doping concentration to the saturable absorbing layer. 500 /spl mu/m-long devices with 51%/51% coated facets were fabricated, resulting in the threshold current of 65 mA at room temperature. The relative intensity noise was below -134 dB/Hz in the temperature ranging from 20 to 60/spl deg/C at 5 mW.
Linker-templated structure tuning of optical response in plasmonic nanoparticle gels (2022)

Gel assemblies of functional nanoparticles, reversibly associated into percolating networks using bifunctional linking molecules, offer promise as versatile materials platforms. Molecular linkers can be customized to template interparticle spacing and modify colloidal network attributes, enabling design for structure-dependent properties. Mechanical properties of gels are commonly studied by molecular simulation, but simulating the optical response of large-scale, disordered assemblies has been computationally intractable, limiting our understanding of light-matter interactions in structurally complex plasmonic networks. Here, we use a recently developed mutual polarization method, capable of predicting optical properties for large disordered configurations of spherical particles, together with an experimentally-informed coarse-grained model to study the behavior of plasmonic linker gels. The simulation results demonstrate how blends of short and long linkers with the same average molecular weight can be chosen to deliberately modulate structure-dependent near- and far-field spectral features of the colloidal gel, while preserving gel mechanical properties. Linker selection can also be used to prepare gel networks with qualitatively different mechano-optical responses. The structural changes occurring under strain shed light on possible origins of experimentally observed red- and blue-shifting of optical extinction of plasmonic nanocomposites under uniaxial extension.
Self-assembly of low-dimensional phase-change nanomaterials for information storage (2007)

Low-dimensional phase-change nanomaterials offer advantages over their bulk counterpart in data storage due to reduced threshold energies for phase transition. These features contribute to low power, scalability, and fast write/erase. We reported synthesis approach and material studies of 1-D chalcogenide materials including GeTe, In <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> Se <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> , and Ge <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> Sb <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> Te <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> nanowires targeted for nonvolatile memories. The phase-change nanowires were synthesized via thermal evaporation under VLS mechanism. The crystal structure, morphology, and composition of the synthesized nanowires were investigated by SEM, EDX, HR-TEM and XPS. The nanowires are structurally uniform with single crystalline structures. Chalcogenide nanowires exhibit significantly reduced melting points, low activation energy and excellent morphology, making them promising nano media for data storage with low energy consumption and excellent scalability.
Comparative Investigation of Throttle-free Load Control on a 2.0 l Four Cylinder Turbocharged Gasoline Engine with Port and Direct Fuel Injection (2010)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;A 2.0 l turbocharged gasoline engine with port injection and a comparable turbocharged gasoline engine with direct injection have been investigated on a test bench at Kaiserslautern Technical University. Both engines were driven with throttle-free load control by fully mechanically variable valve actuation (CVVL). The basic series-production turbocharged engine in this comparison is the version with direct injection without the fully variable valve train. The focuses of the fired tests were investigation of the fuel consumption at part load and of maximum torque behavior at low engine speeds at full load. In both engine modes, use of fully variable valve actuation shows improvements compared with the turbocharged engine versions without CVVL. Better turbocharger response enabled the torque behavior to be optimized. The turbocharged engine with port injection and CVVL matches the torque of the basic turbocharged engine with direct injection and at low engine speeds exceeds the torque of the basic engine. The highest torque at full load and low engine speeds can be obtained with the CVVL turbocharged engine in the direct injection mode. The CVVL turbocharged gasoline engine with port injection shows the highest potential to reduce fuel consumption in this comparative investigation.&lt;/div&gt;&lt;/div&gt;
In vitro cultivation of primary intestinal cells from Eisenia fetida as basis for ecotoxicological studies (2021)

The earthworm Eisenia fetida is a commonly used model organism for unspecific soil feeders in ecotoxicological studies. Its intestinal cells are the first to encounter possible pollutants co-ingested by the earthworm, which makes them prime candidates for studies of toxic effects of environmental pollutants on the cellular as compared to the organismic level. In this context, the aim of this study was to demonstrate the suitability of preparations of primary intestinal E. fetida cells for in vitro ecotoxicological studies. For this purpose, a suitable isolation and cultivation protocol was established. Cells were isolated directly from the intestine, maintaining >85% viability during subsequent cultivations (up to 144 h). Exposure to established pollutants and soil elutriates comprising silver nanoparticles and metal ions (Cu<sup>2+</sup>, Cd<sup>2+</sup>) induced a significant decrease in the metabolic activity of the cells. In case of microplastic particles (MP particles), namely 0.2, 0.5, 2.0, and 3.0 µm diameter polystyrene (PS) beads as well as 0.5 and 2.0 µm diameter polylactic acid (PLA) beads, no active uptake was observed. Slight positive as well as negative dose and size dependent effects on the metabolism were seen, which to some extent might correlate with effects on the organismic level.
Amblyopic reading is crowded (2007)

We measure acuity, crowding, and reading in amblyopic observers to answer four questions. (1) Is reading with the amblyopic eye impaired because of larger required letter size (i.e., worse acuity) or larger required spacing (i.e., worse crowding)? The size or spacing required to read at top speed is called "critical". For each eye of seven amblyopic observers and the preferred eyes of two normal observers, we measure reading rate as a function of the center-to-center spacing of the letters in central and peripheral vision. From these results, we estimate the critical spacing for reading. We also measured traditional acuity for an isolated letter and the critical spacing for identifying a letter among other letters, which is the classic measure of crowding. For both normals and amblyopes, in both central and peripheral vision, we find that the critical spacing for reading equals the critical spacing for crowding. The identical critical spacings, and very different critical sizes, show that crowding, not acuity, limits reading. (2) Does amblyopia affect peripheral reading? No. We find that amblyopes read normally with their amblyopic eye except that abnormal crowding in the fovea prevents them from reading fine print. (3) Is the normal periphery a good model for the amblyopic fovea? No. Reading centrally, the amblyopic eye has an abnormally large critical spacing but reads all larger spacings at normal rates. This is unlike the normal periphery, in which both critical spacing and maximum reading rate are severely impaired relative to the normal fovea. (4) Can the uncrowded-span theory of reading rate explain amblyopic reading? Yes. The case of amblyopia shows that crowding limits reading solely by determining the uncrowded span: the number of characters that are not crowded. Characters are uncrowded if and only if their spacing is more than critical. The text spacing may be uniform, but the observer's critical spacing increases with distance from fixation, so the uncrowded span extends out to where the spacing is critical. Amblyopes have normal critical spacing in the periphery, so, when the uncrowded span extends into the periphery, it has normal extent, which predicts our finding that reading rate is normal too. This confirms the theory that reading rate is determined by the width of the uncrowded span, independent of the critical spacing within the span. The uncrowded-span model of normal reading fits the amblyopic results well, with a roughly fivefold increase in the critical spacing at fixation. Thus, the entire amblyopic reading deficit is accounted for by crowding.