gebhart/patrepeval huggingface dataset:
Zirconium Complexes of 9-Phenyl-9-borataanthracene. Synthesis, Structural Characterization, and Reactivity (1998)

Lithium 9-phenyl-9-borataanthracene (3·Li(THF)x, x = 2 or 3) is obtained quantitatively from the deprotonation of 9-phenyl-9,10-dihydro-9-borataanthracene (6) with LiTMP (TMP = 2,2,6,6-tetramethylpiperidide) in THF. A comparison of the crystallographically determined structures of 6 and 3·Li(TMEDA) (TMEDA = N,N,N‘,N‘-tetramethylethylenediamine) highlights the effects of charge and delocalization on the heterocyclic framework. The reaction of 3·Li(THF)2 with Cp*ZrCl3 (Cp* = C5Me5) and Cp*ZrMe2Cl affords the novel complexes (AnB-Ph)Cp*ZrCl2 (4) (AnB-Ph = 9-phenyl-9-borataanthracene) and (AnB-Ph)Cp*ZrMe2 (5), respectively. The crystallographically determined molecular structure of 4 resembles a bent metallocene with a tetrahedral disposition of ligands around zirconium. The borataanthracene ligand bends significantly (approx 16°) to avoid steric contacts with the Cp*ZrCl2 core. The angle of the exocyclic phenyl substituent relative to the anthracene unit remains nearly invariant at 62° for 6, 3·Li(TMEDA), and 4, suggesting that the steric envelope around boron prevents an optimum orientation for orbital overlap between boron and the π-system of the phenyl ring. Treatment of 5 with B(C6F5)3 gives [(AnB-Ph)Cp*ZrMe][MeB(C6F5)3] (7). Reaction of 4 with methylaluminoxane (MAO) and 1 atm of ethylene produces a mixture of low molecular weight 1-alkenes, 2-alkenes, and 2-alkyl-1-alkenes, whereas the reaction of 7 with ethylene gives low molecular weight polyethylene. Reactions of 4/MAO and 7 with 1-tridecene were carried out to determine the fate of 1-alkenes generated using 4/MAO/C2H4 and to delineate the role of the activator. The complex (C5H5B-Ph)Cp*ZrCl2 (8) is obtained by reaction of Cp*ZrCl3 with Li[C5H5B-Ph]. A comparison of the reactivity of 8/MAO/C2H4 against that of 4/MAO/C2H4 highlights, for the first time, the effect of sterics on the stability of catalysts supported by boratacyclic ligands.
Abstract 9250: Endocardial Electrogram Characteristics Indicating an Epicardial Origin of Focal Ventricular Arrhythmias (2011)

Introduction: While most ventricular arrhythmias (VA) can be ablated successfully using an endocardial (ENDO) approach, epicardial (EPI) mapping and ablation is sometimes required. There may be clues on the surface electrocardiogram related to intrinsicoid deflection and QRS width; however, identification of an EPI origin of VA with certainty remains problematic, and there are no reported ENDO electrogram (EGM) characteristics that may direct ablation strategy. Methods: All patients referred for ablation of ventricular tachycardia or frequent ventricular ectopy from June 2006 through July 2010 were evaluated. Only patients with completed electroanatomical activation maps of a focal VA from ENDO and EPI were included. EGMs recorded by a bipolar mapping catheter in the area of earliest ENDO activation were analyzed and compared to the area of early EPI activation. Results: There were 17 patients with completed ENDO and EPI electroanatomical maps of a focal VA identified. We identified 3 characteristics from ENDO mapping that consistently indicated an EPI VA origin: 1) Diffusely early activation (&gt; 2cm2 region of sites with equally earliest activation within 10 msec; figure); 2) Sequence of a far-field EGM followed by a near-field EGM in the region of earliest ENDO activation; and 3) Inability to capture the far-field component of the earliest ENDO EGM (stimulus-QRS &lt; egm-QRS time) or reproduce the PVC or VT QRS complex morphology with pacing at the earliest ENDO activation site. Conclusions: The presence of a diffuse area of early activation and inability to capture a far-field electrogram from the endocardium indicates an epicardial origin of a focal ventricular arrhythmia.
Cell-Mediated Immune Responses After Influenza Vaccination of Solid Organ Transplant Recipients: Secondary Outcomes Analyses of a Randomized Controlled Trial (2019)

Our study provides novel evidence that HD vaccine elicits greater cellular responses compared with the SD vaccine in SOT recipients, which provides support to preferentially consider use of HD vaccination in the SOT setting.
Diurnal sleep/wake‐related immune functions during the menstrual cycle of healthy young women (1995)

Animal and human studies have related the sleeping/waking brain to the immune system. Because women are more susceptible to certain immunological illnesses, and sex steroids regulate immune functions, it was investigated whether the diurnal sleep/wake pattern of aspects of cellular immune functions and interleukin-1 (IL-1) and IL-2-like activities differed during low and high progesterone phases of the menstrual cycle. Eleven healthy women, mean age 24 y, were assessed over 24 h with serial venous blood samples. Peripheral blood monocytes were assayed for mitogen responses, i.e. phytohemagglutin (PHA) and pokeweed (PWM) and natural killer (NK) cell activities. Plasma was assayed for IL-1 and IL-2-like activities, cortisol and progesterone. Data were standardized by Z transformation and analysed by repeated-measures analysis of variance by comparing high (N = 5) vs. low (N = 6) progesterone phases. During the high progesterone phase, delayed slow-wave sleep (SWS) onset time and reduced amount of SWS was accompanied by a delay in the decline of NK cell activity, but rise in PHA activity following sleep onset. With the low progesterone phase, the pattern was similar to men with an early sleep decline in NK cell and late sleep rise in PHA activities. PWM rose during the night and plasma IL-1-like activity peaked during midday and during nocturnal sleep irrespective of the amount of progesterone. Slow-wave sleep and sleep-related NK cell and PHA activities differed over the menstrual cycle, but not PWM response. Increases in plasma IL-1 functions during midday and night are consistent with predisposition to sleepiness during these times.
Synthesis of 11,12-Bis(alkylthio)-11,12-dicyano-2,6-naphthoquinodimethanes and Their Equilibrium Polymerization Behavior (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 11,12-Bis(alkylthio)-11,12-dicyano-2,6-naphthoquinodimethanes and Their Equilibrium Polymerization BehaviorTakahito Itoh, Toshiyuki Ario, Masahiro Kido, and Shouji IwatsukiCite this: Macromolecules 1994, 27, 24, 7035–7040Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://pubs.acs.org/doi/10.1021/ma00102a005https://doi.org/10.1021/ma00102a005research-articleACS PublicationsRequest reuse permissionsArticle Views53Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Prospective for thermal energy harvesting in mobile computing systems (2010)

Micro and Nano Electro Mechanical Systems (MEMS/NEMS) are disruptive interdisciplinary technologies that can manifest in multiple components in portable systems. Such technologies will play an important role in enabling smaller, more efficient, and faster mobile computing systems. Integrated Radio Frequency MEMS components are front-runners as alternative technologies to replace bulky off chip RF time keeping and frequency control components. MEMS switches co-fabricated with MEMS resonators and filters would reduce the complexity of current mobile platform antennas and extend the reconfigurability of these antennas to operate on a wider range of frequency bands. Energy harvesting is an emerging area where MEMS is expected to play a disruptive role in extending the operational time for small Form-Factor (FF) hand held devices. This paper presents the current mobile platform usage and suggested areas for MEMS/NEMS energy harvesting with focus on thermal energy harvesting environment in mobile devices.
Mechanism of inhibition of natural killing by a glycopeptide isolated from the K562 plasma membrane. (1985)

The mechanism of lysis by cytotoxic T lymphocytes, K cells, and natural killer (NK) cells is imperfectly understood at this point. In this report, material (glycopeptide) isolated from the plasma membranes of K562 cells and fractionated on lectin affinity adsorbents which has been shown to inhibit NK lysis, was used in several specific NK assays to ascertain what stages of the NK-lytic sequence is inhibited by this substance. Results indicate that this glycopeptide (a) does not inhibit initial binding, but dissociates conjugates following initial effector target interactions; (b) inhibits NK lysis beyond Ca-dependent programming, and (c) inhibits lysis induced by NK cell-derived soluble cytotoxic factors (NKCF) in a soluble factor assay. These results suggest that this glycopeptide can effect the lethal hit stage of NK lysis and may represent structures which can associate directly with NKCF.
[()2RhH]‐ und [()2 Rh] [O2 CH]‐Komplexe als Modelle für die Katalytisch aktiven Zwischenstufen der Rh‐Katalysierten Hydrierung von CO2 zu HCOOH (1993)

Die Insertion von CO 2 in die Rh‐H‐Bindung von neutralen Hydridokomplexen unter Bildung ionisch aufgebauter Komplexe vom Typ 1 scheint nun als Schlüsselschritt der Titelreaktion festzustehen ‐ alle Zwischenstufen konnten isoliert oder spektroskopisch nachgewiesen werden. Der Einfluß der Phosphanliganden auf die Reaktivität dieser Modellkomplexe entspricht deren Einfluß auf die Aktivität der normalerweise verwendeten in‐situ‐Katalysatoren. magnified image
Development of new high resolution detectors for small animal SPECT imaging (2002)

Summary form only received as follows: New high-resolution gamma-ray detectors are being developed for SPECT imaging of animals. Optimal collimators, reconstruction algorithms and image processing are an important part of the development of animal SPECT. These issues and recent advances in miniature gamma-ray detectors will be presented. Two lines of technical developments are being followed for high-performance gamma-ray imaging systems: the first uses state-of-the-art position-sensitive photomultiplier tubes (PS-PMTs); the second uses silicon-based photodiode detector arrays. Each are coupled to arrays of scintillation crystals. A small system has been assembled with newly developed PS-PMTs that has 1 mm CsI(Na) crystals and was fitted with a hexagonal parallel hole collimator (1.25 mm holes, 0.25 mm septa, 2 cm long). Line spread functions (LSF) were measured with 0.5 mm line sources filled with Tc-99m. The average FWHM of the LSF curves were 2.12/spl plusmn/0.16 mm and 2.63/spl plusmn/0.15 mm for 0 cm and 1 cm source-collimator distance, respectively. A LSF was made with 1.1 mm pitch (0.85 mm CsI(Tl), 0.25 mm spacing) CsI(Tl)-PIN detector collimated with matching geometry 1 cm long collimator. Mean FWHM=1.91/spl plusmn/0.32 mm. Preliminary images from each system are presented.
Thyrotropin-Releasing Hormone as a Mediator of the Central Autonomic Pathway Controlling Ovarian Function (2003)

We studied the effect of thyrotropin-releasing hormone (TRH) applied centrally on the sympathetic activity of the ovary in female rats. Intracerebroventricular (i.c.v.) administration of a dose of 25 ng/kg weight produced an increase in noradrenaline (NA) content at the ovary after 5 days of hormone administration. However, higher doses in a range up to 500 ng/kg weight decreased NA content at the ovary. At the celiac ganglia (where the cell bodies of sympathetic neurons projecting to the ovary originate) there was an accumulation of NA in spite of a decrease in tyrosine hydroxylase activity (T-OH). After cold exposure, opposite effects on T-OH activity and no effects on NA in ganglia and in ovary were obtained. Besides, i.v. injection of TRH only induced a decrease in ovarian NA. In contrast to the increase in T(3) plasma levels obtained after the cold-stress procedure, none of the i.c.v. doses of TRH used produced changes in T(3) plasma levels, strongly suggesting that the effect on sympathetic activity is mediated by a central effect of TRH acting as a putative activator of ovarian sympathetic nerves.
Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability, and cancer in mice (2004)

BA-1 Genomes of solid tumors can be highly rearranged. Recurrent genome rearrangements are known to involve genes that mediate a wide range of tumor functions including angiogenesis, immortality, survival, metastasis, and resistance to therapy. Genes linked to these rearrangements are increasingly targets of anti-tumor therapeutics. Tumor genomes are not collinear with their normal host genome and current technologies for studying tumor genome structure are not capable of elucidating the structural organization of tumor genomes at high resolution, or of relating it to he underlying sequence. Because of these inherent limitations, the role of translocations and inversions in solid tumors is not well understood. Indeed, even the structural organization of amplicons remains largely enigmatic due to indirect methods of analysis. ESP is a sequence-based method for directly determining the structural organization of tumor genomes, and for cloning structural rearrangements such as translocations, inversions, and complex rearrangements en masse. ESP begins with construction of a BAC library from a tumor. BAC end sequences are then generated for individual BAC clones and mapped onto the normal “reference” genome sequence. This process reveals all classes of structural aberrations including copy number changes, translocations, and inversions, and, importantly, identifies BAC clones spanning associated genome breakpoints. We first demonstrated the power of ESP in an analysis of the breast cancer cell line MCF7 and have now extended it to primary tumors of the brain and breast. For copy number analysis ESP and array CGH are highly concordant although ESP is capable of much higher resolution. In contrast to array CGH, ESP provides direct evidence for the packaging of amplified DNA from multiple loci, and that the packaged DNA may be highly rearranged. ESP provides evidence for independent mechanisms of amplification operating within a single tumor genome. Approximately 80% of identified translocations and inversions tested were confirmed, and evidence for chimeric transcripts is emerging. Whole genome ESP is being combined with robust mathematical methods for tumor genome assembly enabling the formal testing of hypotheses of tumor evolution. ESP is inherently integrative and thus brings the power of genetic analysis to interpretation of complex expression microarray and proteomic data. Further, it enables construction of mice transgenic for BAC clones carrying human tumor DNA, thus preserving the nuances of transcriptional regulation and alternative splicing and allowing for the functional dissection of inversions, translocations, and amplicons in model systems. Finally, ∼ 200 tumor genomes can be effectively immortalized and exhaustively analyzed by ESP for less than the cost of sequencing a single mammalian sized genome.
Teaching and Learning Electromagnetics in 2020: Issues, trends, opportunities, and ideas for developing courses (2020)

Electromagnetics (EM) and its applications have been a vital part of scientific and engineering instruction for well over a century. As approaches, applications, and curricular models evolve, educators in the field face many challenges and pressures. Here, we consider issues that face those who teach EM theory, identify some of the trends and opportunities that lie ahead, and make recommendations for the next decade of training and course development in the field of EM.
CINE MRT mit paralleler Bildgebung bei 3 Tesla: Signal Parameter und volumetrische Genauigkeit im Vergleich zu 1,5 Tesla (2006)

Ziele: Zur Evaluierung der diagnostischen Genauigkeit einer beschleunigten CINE MRT bei 3 Tesla und zur Evaluierung der Signalparameter im Vergleich zu 1,5 Tesla. Methode: 10 Patienten wurden bei 1.5T (MAGNETOM Avanto) und 3T (MAGNETOM Trio TIM) mit einer CINE SSFP Technik zur Funktionsbeurteilung untersucht. Die Datenakquisition erfolgte bei beiden Feldstärken jeweils mit einer Standard-Einzelschicht CINE Technik und einer beschleunigten CINE Mehrschichttechnik (5 Schichten/Atemanhaltephase; TSENSE, R=4). Es wurden die linksventrikulären Funktionsparameter (EDV, ESV, EF) sowie SNR und CNR analysiert. SNR und CNR der beschleunigten Datenaufnahmen wurden unter Zuhilfenahme von Phantombasierten g-Faktoren abgeschätzt. Der Auswertung der Volumetrie und der Signalmessungen erfolgte im Vergleich zur nicht-beschleunigten CINE SSFP bei 1,5T als Referenzstandard (SOR). Ergebnis: Die Einzelschicht CINE bei 3T zeigte einen~90% Anstieg des CNR im Vergleich zu 1.5T (P<0,001). Bei 3T Betrug der durch TSENSE bedingte Abfall des CNR 58±6% im Vergleich zur Einzelschichttechnik während der Abfall bei 1,5T ~71±2%. 3T TSENSE CINE zeigte ein nur ~21% niedrigeres CNR im Vergleich zum SOR (P<0,05). Die EF und ESV Ergebnisse aller Datensätze zeigten keine signifikanten Unterschiede zum SOR während für das EDV Unterschiede von -5,1±4,9ml (P=0,01), 11,0±7,8ml (P=0,002) und 1,5±11,6ml (P=0,7) für 1,5T TSENSE CINE, 3T CINE und 3T TSENSE CINE festgestellt wurden. Die Datenakquisition verkürzte sich mit TSENSE Beschleunigung signifikant (P<0,001). Schlussfolgerung: Der SNR Verlust durch 4-fache Beschleunigung mit TSENSE bei 1,5T kann durch den intrinsischen Signalanstieg bei 3T nahezu kompensiert werden. Mehrschicht CINE SSFP bei 3T ermöglicht eine adäquate LV Volumetrie bei verkürzter Untersuchungsdauer.
Soft Electronic Strain Sensor with Chipless Wireless Readout: Toward Real‐Time Monitoring of Bladder Volume (2018)

Abstract Sensing mechanical tissue deformation in vivo can provide detailed information on organ functionality and tissue states. To bridge the huge mechanical mismatch between conventional electronics and biological tissues, stretchable electronic systems have recently been developed for interfacing tissues in healthcare applications. A major challenge for wireless electronic implants is that they typically require microchips, which adds complexity and may compromise long‐term stability. Here, a chipless wireless strain sensor technology based on a novel soft conductor with high cyclic stability is reported. The composite material consists of gold‐coated titanium dioxide nanowires embedded in a soft silicone elastomer. The implantable strain sensor is based on an resonant circuit which consists of a stretchable plate capacitor and a coil for inductive readout of its resonance frequency. Successful continuous wireless readout during 50% strain cycles is demonstrated. The sensor element has a Young's modulus of 260 kPa, similar to that of the bladder in order to not impair physiological bladder expansion. A proof‐of‐principle measurement on an ex vivo porcine bladder is presented, which shows the feasibility of the presented materials and devices for continuous, wireless strain monitoring of various tissues and organs in vivo.
Percutaneous Intrarenal Electrosurgery (1984)

A 16F nephroscope with a 5F cutting element was used for percutaneous removal of kidney stones in 10 patients in whom an open operation otherwise would have been necessary. Stone removal was accomplished via percutaneous incision of narrowed infundibula, caliceal diverticula and the ureteropelvic junction. A thorough knowledge of renal vasculature, meticulous care and fluoroscopic control are necessary for successful percutaneous intrarenal electrosurgery.
Anionic Platinum Complexes with 2-Pyridylphosphines as Ligands for Rhodium:  Synthesis of Zwitterionic Pt−Rh Organometallic Compounds (2003)

Bimetallic zwitterionic platinum(II)-rhodium(I) complexes of the type [(C(6)F(5))(3)Pt(micro-PPy(n)Ph(3)(-)(n)Rh(CO)(2))] and [(C(6)F(5))(3)Pt(micro-PPy(n)Ph(3)(-)(n)())Rh(diene))] (n = 2, 3; Py = 2-pyridyl) have been prepared. The P end of the bridging ligands (micro-PPy(n)Ph(3)(-)(n)) is always coordinated to the Pt center, while the N-donor ends chelate the Rh atom, giving metallacycles comparable to pyrazolylborate-Rh complexes. These metallacycles can adopt two conformations, either with the Pt complex in pseudoaxial position approaching the Rh center or with the Pt complex in a remote position. The preferred conformation depends on the steric hindrance at the rhodium center. In less sterically demanding Rh-carbonyl complexes the Pt moiety gets close to the Rh moiety as this brings closer the opposite charges of the zwitterion. For diene complexes mixtures of conformers are obtained. The X-ray structures of [(C(6)F(5))(3)Pt(micro-PPhPy(2))Rh(COD)] (COD = 1,5-cyclooctadiene) and [(C(6)F(5))(3)Pt(micro-PPhPy(2))Rh(CO)(2)] are reported.
N-Acetylsphingosine stimulates phosphatidylglycerolphosphate synthase activity in H9c2 cardiac cells (1999)

Cardiolipin and phosphatidylglycerol biosynthesis were examined in H9c2 cells incubated with short-chain ceramides. Incubation of cells with N-acetylsphingosine or N-hexanoylsphingosine stimulated [1,3-3H]glycerol incorporation into phosphatidylglycerol and cardiolipin, with N-acetylsphingosine having the greater effect. The mechanism for the ceramide-mediated stimulation of de novo phosphatidylglycerol and cardiolipin biosynthesis appeared to be an increase in the activity of phosphatidylglycerolphosphate synthase, the committed step of phosphatidylglycerol and cardiolipin biosynthesis. The presence of the potent protein phosphatase inhibitors calyculin A or okadaic acid attenuated the N-acetylsphingosine-mediated stimulation of phosphatidylglycerolphosphate synthase activity and of phosphatidylglycerol and cardiolipin biosynthesis, indicating the involvement of a ceramide-activated protein phosphatase(s). The presence of 8-(4-chlorophenylthio)-cAMP (CPT-cAMP) stimulated enzyme activity and [1,3-3H]glycerol incorporation into phosphatidylglycerol and cardiolipin. The effects of CPT-cAMP and N-acetylsphingosine on phosphatidylglycerol and cardiolipin biosynthesis and on phosphatidylglycerolphosphate synthase activity were additive. Phosphatidylglycerol biosynthesis from sn-[14C]glycerol 3-phosphate in permeabilized H9c2 cells was stimulated by preincubation with N-acetylsphingosine, and this was attenuated by okadaic acid. N-Acetylsphingosine treatment of cells elevated mitochondrial phospholipase A2 activity. Since the pool sizes of phosphatidylglycerol and cardiolipin were unaltered in these cells, the observed increase in phosphatidylglycerolphosphate synthase activity may be a compensatory mechanism for the N-acetylsphingosine-mediated elevation of mitochondrial phospholipase A2 activity. Finally, addition of tumour necrosis factor α to H9c2 cells resulted in an elevation of both phosphatidylglycerolphosphate synthase and phospholipase A2 activities. The results suggest that phosphatidylglycerol and cardiolipin metabolism in H9c2 cells may be regulated by intracellular ceramide signalling.
A DSP based bit-synchronization algorithm (2002)

This paper describes a software based bit-sync algorithm implemented on a fixed point digital signal processor (DSP). This implementation is used to process the audio output from a radio. It is a minimal hardware implementation. It employs a bit-sync algorithm which is a modification of the lead-lag digital phase-lock loop (LL-DPLL) algorithm of Cessna and Levy (1972).