gebhart/patrepeval huggingface dataset:
Human CABIN1 Is a Functional Member of the Human HIRA/UBN1/ASF1a Histone H3.3 Chaperone Complex (2011)

The mammalian HIRA/UBN1/ASF1a complex is a histone chaperone complex that is conserved from yeast (Saccharomyces cerevisiae) to humans. This complex preferentially deposits the histone variant H3.3 into chromatin in a DNA replication-independent manner and is implicated in diverse chromatin regulatory events from gene activation to heterochromatinization. In yeast, the orthologous complex consists of three Hir proteins (Hir1p, Hir2p, and Hir3p), Hpc2p, and Asf1p. Yeast Hir3p has weak homology to CABIN1, a fourth member of the human complex, suggesting that Hir3p and CABIN1 may be orthologs. Here we show that HIRA and CABIN1 interact at ectopic and endogenous levels of expression in cells, and we isolate the quaternary HIRA/UBN1/CABIN1/ASF1a (HUCA) complex, assembled from recombinant proteins. Mutational analyses support the view that HIRA acts as a scaffold to bring together UBN1, ASF1a, and CABIN1 into a quaternary complex. We show that, like HIRA, UBN1, and ASF1a, CABIN1 is involved in heterochromatinization of the genome of senescent human cells. Moreover, in proliferating cells, HIRA and CABIN1 regulate overlapping sets of genes, and these genes are enriched in the histone variant H3.3. In sum, these data demonstrate that CABIN1 is a functional member of the human HUCA complex and so is the likely ortholog of yeast Hir3p.
Monostatic Backscattering Detection by Multiantenna Reader (2019)

The limitations of backscatter communication (BSC) can be overcome by exploiting advantages of the multipleinput-multiple-output (MIMO) technology at the reader. In this paper we propose a novel maximum eigenvalue based BSC detection protocol for a monostatic MIMO reader to minimize the underlying bit error rate (BER). Specifically, two orthonormal sequences for the backscattering coefficients (BC) at the single-antenna tag are used to exploit the rank-one property of the cascaded BSC channels in monostatic settings for detection at the reader without requiring any help from the low-power tag in channel estimation. Lastly, the efficacy of the proposed detection protocol is numerically quantified while shedding key insights on the impact of the key simulation parameters like rice factor, orthonormal sequence length, array size, and signal-to-noise-ratio on the achievable BER.
TU‐E‐BRB‐10: Investigation of the Water‐to‐Air Stopping Power Ratio for Carbon Ion Beam Dosimetry Based on Experimental Data and FLUKA Simulation (2011)

Purpose: Water‐to‐air stopping power ratio (Sw,air) is currently known with an uncertainty of 2% for carbon ion beams (IAEAˈs TRS‐398), and it is the main source of uncertainty in absolute dosimetry with air‐filled ionization chambers. We present here a more precise calculation of its value from measurements performed under controlled experimental conditions Methods: Sw,air is given in TRS‐398 as a particle fluence weighted average over all particles and energies, and it is derived from track‐lenght fluence of each particle in water and its mass stopping powers in water and air. All these quantities were calculated with the general‐purpose Monte Carlo code FLUKA. The input values to the code, including water and air mean ionization potentials of Iw = 75.9 ± 0.2 eV and Iair = 87 ± 3 eV, were chosen in accordance to experimental measurements of mono‐energetic carbon ion beams carried out at the Heidelberg Ion Therapy Center (HIT). The Sw,air was calculated for spread‐out Bragg Peaks (SOBPs) at different depths, and a possible dependence on the residual range was investigated. Results: For all the studied SOBPs, the uncertainty in the stopping power ratio could be reduced significantly by introducing a logarithmic dependence on the residual range. Moreover, using the fixed value of Sw,air =1.13 causes, on average, a dose underestimation of 0.1 % if used in the plateau area and of 0.4% if used n the peak (compared to Monte Carlo data), whereas using our Sw,air(z) model reduces this dose underestimation below 0.05% in all cases. Conclusions: The contribution presents a revised calculation of the water‐to‐air stopping power ratio using own experimental data that reduces significantly the uncertainty of the current reference value. The research leading to these results has received funding from the European Communityˈs Seventh Framework Programme 2007–2013 under grant agreement n° 215840‐2 (PARTNER).
ChemInform Abstract: Gastroprotective Agents for the Prevention of NSAID‐Induced Gastropathy (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Determination of Bioavailable Contaminants in the Lower Missouri River following the Flood of 1993 (1998)

The semipermeable membrane device (SPMD) technology was employed to determine the presence of bioavailable organochlorine pesticides (OCs), polychlorinated biphenyls (PCBs), and polyaromatic hydrocarbons (PAHs) in the water of the main stem of the lower Missouri River and three of its tributaries. The SPMDs were deployed in 1994 following the extensive flood of 1993. Specifically, the SPMDs were deployed for 28 days at Wilson State Park, IA; Nebraska City, NE; Parkville, MO; the Kansas River in Kansas City, KS; Napoleon, MO; the Grand River; Glasgow, MO; the Missouri River upstream from the confluence of the Gasconade River; the Gasconade River; and Hermann, MO. Contaminant residues were found at all sites and at higher concentrations than found in the earlier pre-flood sampling. For example, in the present study, dieldrin was found to range from a low of 110 ng/sample in the Gasconade River to a high of 2000 ng/sample at Glasgow, while in the pre-flood sampling, dieldrin ranged from a low of 64 ng/sample at Sioux City to a high of 800 ng/sample at Glasgow. In contrast to the 1992 sampling, residues of PCBs were found at all 1994 sampling sites except the Gasconade River. Samples from Wilson State Park and the Grand River had 3100 and 2700 ng of PCBs/sample, respectively. These two concentrations are about an order of magnitude higher than the other sites and are likely indicative of point source inputs. PAHs were present in SPMD samples from three sites near Kansas City. The contaminant residues sequestered by the SPMDs represent an estimation of the bioavailable (via respiration) contaminants present in the main stem of the lower Missouri River and three of its major tributaries following an extensive flood event.
Development of Kenaf Fiber-Reinforced Polylactic Acid for Use in Electronic Products (2005)

電子機器用の植物原料の筐体材料として, ケナフ繊維で強化したポリ乳酸複合材料を開発した. ポリ乳酸に二酸化炭素固定能力の高いケナフの繊維を添加することで, ポリ乳酸の耐熱性 (熱変形温度) と剛性を大幅に向上でき (熱変形温度, 曲げ弾性率ともに1.7倍以上), さらにポリ乳酸の結晶化を促進させることで成形性も改善できた. 加えて, ケナフ繊維中の短繊維の除去や, 可とう性付与剤 (乳酸と脂肪族ポリエステルの共重合体) の添加によって, 衝撃強度の向上が可能であることを明らかにした. さらに, ケナフ中に含まれる水溶成分の除去によって, この複合材料の着色性の改良も可能になった. 本開発のケナフ繊維添加ポリ乳酸複合材料は, 既存の石油原料系筐純体用樹脂のガラス繊維強化ABS以上の主要特性を実現し, 実用可能である.
A 29-mRNA Host Response Test from Blood Accurately Distinguishes Bacterial and Viral Infections Among Emergency Department Patients (2020)

Abstract Study design Whether or not to administer antibiotics is a common and challenging clinical decision in patients with suspected infections presenting to the emergency department (ED). We prospectively validate InSep, a 29-mRNA blood-based host response test for the prediction of bacterial and viral infections. Methods The PROMPT trial is a prospective, non-interventional, multi-center randomized, controlled clinical trial that enrolled 397 adult patients presenting to the ED with signs of acute infection and at least one vital sign change. The infection status was adjudicated using chart review (including a syndromic molecular respiratory panel, procalcitonin and C-reactive protein) by three infectious disease physicians blinded to InSep results. InSep (version BVN-2) was performed using PAXgene Blood RNA processed and quantified on NanoString nCounter SPRINT. InSep results (likelihood of bacterial and viral infection) were compared to the adjudicated infection status. Results Subject mean age was 64 years, comorbidities were significant for diabetes (17.1%), chronic obstructive pulmonary disease (13.6%), and severe neurological disease (6.8%); 16.9% of subjects were immunocompromised. Infections were adjudicated as bacterial (14.1%), viral (11.3%) and noninfected (0.25%): 74.1% of subjects were adjudicated as indeterminate. InSep distinguished bacterial vs. viral/noninfected patients and viral vs. bacterial/noninfected patients using consensus adjudication with AUROCs of 0.94 (95% CI 0.90-0.99) and 0.90 (95% CI 0.83-0.96), respectively. AUROCs for bacterial vs. viral/noninfected patients were 0.88 (95%CI 0.79-0.96) for PCT, 0.80 (95% CI 0.72-89) for CRP and 0.78 (95% CI 0.69-0.87) for white blood cell counts (of note, the latter biomarkers were provided as part of clinical adjudication). To enable clinical actionability, InSep incorporates score cutoffs to allocate patients into interpretation bands. The Very Likely (rule in) InSep bacterial band showed a specificity of 98% compared to 94% for the corresponding PCT band (&gt;0.5 ug/L); the Very Unlikely (rule-out) band showed a sensitivity of 95% for InSep compared to 86% for PCT. For the detection of viral infections, InSep demonstrated a specificity of 93% for the Very Likely band (rule in) and a sensitivity of 96% for the Very Unlikely band (rule out). Conclusion InSep demonstrated high accuracy for predicting the presence of both bacterial and viral infections in ED patients with suspected acute infections or suspected sepsis. When translated into a rapid, point-of-care test, InSep will provide ED physicians with actionable results supporting early informed treatment decisions to improve patient outcomes while upholding antimicrobial stewardship. Take-home message InSep host response test is a point-of-care test providing with accuracy the likelihood for bacterial or viral infection for patients admitted at the emergencies InSep provided information on the likelihood of bacterial co-infection among patients with COVID-19.
Glutamine synthesis in the perfused rat kidney and in isolated rat cortical tubules: regulation by pH (1985)

The possible involvement of renal glutamine synthesis in the regulation of ammoniagenesis during metabolic acidosis has been investigated. Using an isotope dilution technique glutamine synthesis has been demonstrated in the intact perfused rat kidney, despite zero net balance for glutamine in this preparation. Inhibition of glutamine synthesis resulted in increased ammonia production in isolated cortical tubules. The rates of these processes were comparable. We conclude that recycling of nitrogen through glutamine synthesis and glutamine hydrolysis could play a quantitatively significant role in the control of ammonia excretion by the kidney, particularly in acute acidosis where the fall in pH seems to inhibit glutamine synthesis.
Structural Investigation of Silver Vanadium Phosphorus Oxide (Ag2VO2PO4) and Its Reduction Products (2021)

A combination of powder XRD, solid-state NMR, and electrochemical impedance spectroscopy (EIS) is utilized to study the high capacity primary lithium battery cathode material (Ag2VO2PO4), as well as its electrochemically reduced counterparts. EIS provides information about the reduction process, and powder XRD is useful in determining the structure of pristine SVPO and the 1 electron equivalent (1ee) reduced materials, which are crystalline and contain edge-sharing VO6 units. However, SVPO becomes increasingly paramagnetic and amorphous as reduction proceeds from 1ee up to 3ee. Here we probe the VO6 coordination environment in the parent SVPO material as well as the reduced materials using both static and magic-angle spinning solid-state 51V NMR spectroscopy. The chemical shielding anisotropy (CSA) and electric field gradient (EFG) NMR tensors were determined through fitting of the spinning side bands or via density functional theory (CASTEP), or both. These tensors provide useful insight into the structure of the reduced materials. All materials exhibit similar isotropic chemical shifts for 51V; however, other line-shape elements vary as the coordination environment changes upon reduction. We find that the 51V NMR tensor parameters (δCS and CQ) are better at indicating changes to the local environment than the isotropic chemical shift.
Supplementary Table 1 from Somatic Epigenetic Silencing of <i>RIPK3</i> Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma (2023)

&lt;p&gt;Patient background information for 27 primary pleural malignant mesothelioma (MM) samples used in this investigation.&lt;/p&gt;
Deep neural network goes lighter: A case study of deep compression techniques on automatic RF modulation recognition for Beyond 5G networks (2022)

Automatic RF modulation recognition is a primary signal intelligence (SIGINT) technique that serves as a physical layer authentication enabler and automated signal processing scheme for the beyond 5G and military networks. Most existing works rely on adopting deep neural network architectures to enable RF modulation recognition. The application of deep compression for the wireless domain, especially automatic RF modulation classification, is still in its infancy. Lightweight neural networks are key to sustain edge computation capability on resource-constrained platforms. In this letter, we provide an in-depth view of the state-of-the-art deep compression and acceleration techniques with an emphasis on edge deployment for beyond 5G networks. Finally, we present an extensive analysis of the representative acceleration approaches as a case study on automatic radar modulation classification and evaluate them in terms of the computational metrics.
Wound infiltration with liposomal bupivacaine prolongs analgesia in rats (1997)

The 8-fold increase in duration of wound analgesia and the lower plasma levels seen with the liposomal formulation are explained by gradual drug release from the liposomal depot. These results may have important implications for achieving safe and effective analgesia with wound infiltration techniques in humans.
Computational Investigations of Pore Forming Peptide Assemblies in Lipid Bilayers (2006)

This Letter presents the first application of a three-dimensional numerical molecular theory based modeling approach to study the structure and energetics of assemblies of peptides embedded in lipid bilayers. Coarse-grained models were used for both the peptides and lipids. Both barrel-stave and toroidal pore morphologies for the lipids near the peptide assemblies are found, but at different assembly sizes. The free energy of the assembly is found to have a global free energy minimum for a solution with a membrane-spanning toroidal pore. A pairwise approximation to this free energy is found to underpredict the free energy minimum associated with the membrane-spanning pores.
High-efficiency monolithic GaAs power MESFET amplifier operating with a single low voltage supply for 1.9-GHz digital mobile communication applications (2002)

A monolithic GaAs power amplifier IC using refractory WN/sub xW self-aligned gate power MESFETs has been developed for 1.9-GHz digital mobile communication systems, such as the Japanese personal handy phone system. The power amplifier operates with high efficiency and low distortion with a single low voltage supply of 2.7-3.0 V, by virtue of small drain knee voltage, high transconductance and sufficient breakdown voltage of the power MESFET. An output power of 23.7 dBm and a high power-added efficiency of 24.2% were attained at 3 V for 1.9-GHz /spl pi4-shifted QPSK (quadrature phase shift keying) modulated input when adjacent channel leakage power was -58 dBc at 600 kHz apart.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Host-guest chemistry: Combinatorial receptors (1999)

A combinatorial approach to receptor design provides an expedient method to discover the most effective host-guest complexes from within a library. Recent advances focus on generation of larger libraries, facile detection, combinatorial catalysis and the formation of dynamic receptor libraries.
Repair And Retrofit With Engineered Cementitious Composites (1998)

Peer Reviewed
Muconic acid isomers as platform chemicals and monomers in the biobased economy (2020)

A complete overview of the chemical and biotechnological synthesis of muconic acid, its isomerization, and valorization into chemicals and polymers is presented.
[15N]Alanine and [15N]ammonia metabolism: a reply (1991)

Reply| May 15 1991 [15N]Alanine and [15N]ammonia metabolism: a reply Neil Farrow; Neil Farrow 1Magnetic Resonance Spectroscopy Laboratory, Huntington Medical Research Institutes, 660 S. Fair Oaks Avenue, Pasadena, CA 91105, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Keiko Kanamori; Keiko Kanamori 1Magnetic Resonance Spectroscopy Laboratory, Huntington Medical Research Institutes, 660 S. Fair Oaks Avenue, Pasadena, CA 91105, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Brian D. Ross; Brian D. Ross 1Magnetic Resonance Spectroscopy Laboratory, Huntington Medical Research Institutes, 660 S. Fair Oaks Avenue, Pasadena, CA 91105, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Farhad Parivar Farhad Parivar 1Magnetic Resonance Spectroscopy Laboratory, Huntington Medical Research Institutes, 660 S. Fair Oaks Avenue, Pasadena, CA 91105, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1991) 276 (1): 272. https://doi.org/10.1042/bj2760272 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation Neil Farrow, Keiko Kanamori, Brian D. Ross, Farhad Parivar; [15N]Alanine and [15N]ammonia metabolism: a reply. Biochem J 15 May 1991; 276 (1): 272. doi: https://doi.org/10.1042/bj2760272 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1991 The Biochemical Society, London1991 Article PDF first page preview Close Modal You do not currently have access to this content.
Loop Transformation Methodologies for Array-Oriented Memory Management (2006)

The storage requirements in data-dominant signal processing systems, whose behavior is described by arraybased, loop-organized algorithmic specifications, have an important impact on the overall energy consumption, data access latency, and chip area. Applying different loop transformations on the specification code can significantly enhance the memory management of such VLSI systems, improving all the major parameters of the design space - power, area, and performance. This paper gives a global view on existing and recently proposed memory size evaluation approaches for procedural and non-procedural specifications. Moreover, it discusses typical memory management trade-offs taken into account during the exploration of system specifications by loop transformations, that can exploit these early size evaluations.
Polarization diversity antenna with L-shaped slit for wireless sensor network (2012)

In this paper, a planar polarization diversity antenna with low correlation coefficient and low mutual coupling is developed for wireless sensor network system at UHF region. A slit, to eliminate mutual coupling between two antennas, inserted on ground plane of conventional diversity antenna is straight; this fact causes a restriction to layout of a PCB board at UHF region. To save a large area for the electric component, we employ an L-shaped slit which has an advantage of compact and same performance as straight slit. The prototype of diversity antenna has been developed and measured. The measured result obtained the very low correlation coefficient of 0.021 and very low mutual coupling about -20 dB at 1 GHz in this work.
A Facile Access to Substituted 2-Nitrosophenols and 2-NitrophenolsviaRegioselective Nitrosation of Resorcinol Monoethers (1995)

Abstract Solid sodium nitrite in anhydrous propionic acid is an effective system for regioselective nitrosation of the subject compounds. High yields of pure 2-nitroso products are obtained rapidly and efficiently. Attack at the 4-position becomes competitive if water is present in the medium. The 5-alkoxy (but not the 3,5-dialkoxy)-2-nitrosphenols can be easily oxidized with nitric acid to yield the corresponding 2-nitro compounds.
Reduced-order synchrophasor-assisted state estimation for smart grids (2012)

Phasor measurement units (PMUs) are being increasingly deployed in power systems where they are used for state estimation (SE) among other applications. In this paper, we present a computationally efficient approach to SE based on model-order reduction. The proposed algorithm operates separately on PMU measurements and on conventional measurements, using reduced-dimension matrices. This approach reduces the computational load considerably without significantly affecting accuracy. Moreover, this scheme supports distributed implementation and is numerically stable. The performance of the proposed estimation algorithm is examined with the IEEE 14-bus system and compared with existing schemes in the literature.
Report from the SWOG Radiation Oncology Committee: Research Objectives Workshop 2017 (2018)

The Radiation Therapy Committee of SWOG periodically evaluates its strategic plan in an effort to maintain a current and relevant scientific focus, and to provide a standard platform for future development of protocol concepts. Participants in the 2017 Strategic Planning Workshop included leaders in cancer basic sciences, molecular theragnostics, pharmaceutical and technology industries, clinical trial design, oncology practice, and statistical analysis. The committee discussed high-priority research areas, such as optimization of combined modality therapy, radiation oncology-specific drug design, identification of molecular profiles predictive of radiation-induced local or distant tumor responses, and methods for normal tissue-specific mitigation of radiation toxicity. The following concepts emerged as dominant questions ready for national testing: (i) what is the role of radiotherapy in the treatment of oligometastatic, oligorecurrent, and oligoprogressive disease? (ii) How can combined modality therapy be used to enhance systemic and local response? (iii) Can we validate and optimize liquid biopsy and other biomarkers (such as novel imaging) to supplement current response criteria to guide therapy and clinical trial design endpoints? (iv) How can we overcome deficiencies of randomized survival endpoint trials in an era of increasing molecular stratification factors? And (v) how can we mitigate treatment-related side effects and maximize quality of life in cancer survivors? The committee concluded that many aspects of these questions are ready for clinical evaluation and example protocol concepts are provided that could improve rates of cancer cure and quality of survival. <i>Clin Cancer Res; 24(15); 3500-9. ©2018 AACR</i>.
Additional file 2: Figure S2. of Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors (2015)

The endocytosis of NMDARs (the GluN2A and GluN2B subunits). (PDF 280 kb)