gebhart/patrepeval huggingface dataset:
Methyl isocyanaide isomerization. Determination of collisional deactivation parameters following carbon-hydrogen overtone excitation (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMethyl isocyanaide isomerization. Determination of collisional deactivation parameters following carbon-hydrogen overtone excitationDeanne L. Snavely, Richard N. Zare, James A. Miller, and David W. ChandlerCite this: J. Phys. Chem. 1986, 90, 16, 3544–3549Publication Date (Print):July 1, 1986Publication History Published online1 May 2002Published inissue 1 July 1986https://pubs.acs.org/doi/10.1021/j100407a018https://doi.org/10.1021/j100407a018research-articleACS PublicationsRequest reuse permissionsArticle Views129Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Structured support vector machines for noise robust continuous speech recognition (2011)

The use of discriminative models is an interesting alternative to generative models for speech recognition. This paper examines one form of these models, structured support vector machines (SVMs), for noise robust speech recognition. One important aspect of structured SVMs is the form of the joint feature space. In this work features based on generative models are used, which allows model-based compensation schemes to be applied to yield robust joint features. However, these features require the segmentation of frames into words, or subwords, to be specified. In previous work this segmentation was obtained using generative models. Here the segmentations are refined using the parameters of the structured SVM. A Viterbilike scheme for obtaining optimal segmentations, and modifications to the training algorithm to allow them to be efficiently used, are described. The performance of the approach is evaluated on a noise corrupted continuous digit task: AURORA 2. Copyright © 2011 ISCA.
Broadband precision spectroscopy using a scanning diode laser and a frequency comb (2009)

We present a versatile approach that allows for both precise and broadband measurements of transmission spectra by transferring the precision of an optical frequency comb to a mode-hop free tunable external cavity diode laser. The advantage of using a tunable diode laser compared to other methods such as direct frequency comb spectroscopy or multi-heterodyne spectroscopy is the ability to resolve spectral features that are much smaller than the repetition rate of the employed frequency combs (for instance the MHz-linewidth modes of an ultra high-Q microcavity). The potential of the technique is demonstrated by measuring for the first time the small residual dispersion of optical microcavities.
The Proteasome Inhibitor Carfilzomib Suppresses Parathyroid Hormone-induced Osteoclastogenesis through a RANKL-mediated Signaling Pathway (2015)

Parathyroid hormone (PTH) induces osteoclast formation and activity by increasing the ratio of RANKL/OPG in osteoblasts. The proteasome inhibitor carfilzomib (CFZ) has been used as an effective therapy for multiple myeloma via the inhibition of pathologic bone destruction. However, the effect of combination of PTH and CFZ on osteoclastogenesis is unknown. We now report that CFZ inhibits PTH-induced RANKL expression and secretion without affecting PTH inhibition of OPG expression, and it does so by blocking HDAC4 proteasomal degradation in osteoblasts. Furthermore, we used different types of culture systems, including co-culture, indirect co-culture, and transactivation, to assess the effect of CFZ on PTH action to induce osteoclastogenesis. Our results demonstrated that CFZ blocks PTH-induced osteoclast formation and bone resorption by its additional effect to inhibit RANKL-mediated IκB degradation and NF-κB activation in osteoclasts. This study showed for the first time that CFZ targets both osteoblasts and osteoclasts to suppress PTH-induced osteoclast differentiation and bone resorption. These findings warrant further investigation of this novel combination in animal models of osteoporosis and in patients.
Supplementary Table S2 from Individualized Systems Medicine Strategy to Tailor Treatments for Patients with Chemorefractory Acute Myeloid Leukemia (2023)

&lt;p&gt;- XLSX file 977K, Drug sensitivity profiles of AML and control samples&lt;/p&gt;
Insights into internal dynamics of 6‐phosphogluconolactonase from Trypanosoma brucei studied by nuclear magnetic resonance and molecular dynamics (2011)

Nuclear magnetic resonance is used to investigate the backbone dynamics in 6-phosphogluconolactonase from Trypanosoma brucei (Tb6PGL) with (holo-) and without (apo-) 6-phosphogluconic acid as ligand. Relaxation data were analyzed using the model-free approach and reduced spectral density mapping. Comparison of predictions, based on 77 ns molecular dynamics simulations, with the observed relaxation rates gives insight into dynamical properties of the protein and their alteration on ligand binding. Data indicate dynamics changes in the vicinity of the binding site. More interesting is the presence of perturbations located in remote regions of this well-structured globular protein in which no large-amplitude motions are involved. This suggests that delocalized changes in dynamics that occur upon binding could be a general feature of protein-target interactions.
Table S2 from Computational Staining of Pathology Images to Study the Tumor Microenvironment in Lung Cancer (2023)

&lt;p&gt;Supplemental Table S2. Image features that are significantly associated with patient overall survival outcome in univariate survival analysis in the National Lung Screening Trial (NLST) dataset. Features are dichotomized by the median value. P values are calculated using Ward test. CI, confidence interval; HR, hazard ratio.&lt;/p&gt;
In situ Measurements of Potential, Current, and Charging Rate across an Ultracapacitor Electrode (2011)

Abstract not Available.
Motion Estimation of Human Arm for Robot Teaching System using Inertial Sensors and its Application to Robot Arm (2019)

Conventional teaching methods include remote teaching and direct teaching. These teaching methods have problems in terms of difficulty teaching sensibly and safety of the teacher. In order to solve these problems, sensuous but remote teaching is ideal for the teacher. In this research, I propose a remote and sensuous teaching system by attaching inertial sensors to the arm of the teacher that estimate teaching motions．In general, optical motion capture is used as a motion measurement method. It is advantageous in that positional information can be directly obtained, but the devices that use it are large, expensive, and have dead angles. Therefore, motion measurement methods using microelectromechanical systems (MEMS) inertial sensors have been proposed. The system proposed in this study uses a downsized, reduced-price MEMS sensor. Therefore, we extracted the target position of the robot to be taught using inertial sensors and verified applying robot arm. In this paper, I proposed and verified a correction method using gravitational acceleration in arm motion estimation using inertial sensors. As a result, I showed that by correcting the mounting error, the estimation accuracy would be better than before correction. In addition, I proposed and verified a system to teach a robot arm using the proposed arm motion estimation system. As a result, it was found that teaching is possible to the robot arm if the object is large and simple grasping motion, which indicates the effectiveness of the teaching system proposed this time.
Urtica dioica agglutinin, a Vβ8.3‐specific superantigen, prevents the development of the systemic lupus erythematosus‐like pathology of MRL lpr/lpr mice (1996)

The V beta 8.3-specific superantigenic lectin Urtica dioica agglutinin (UDA) was used to delete the V beta 8.3+ T cells in MRL lpr/lpr mice. In contrast to the systemic lupus erythematosus-like pathology which progresses with age in the phosphate-buffered saline-injected MRL lpr/lpr controls, UDA-treated animals did not develop overt clinical signs of lupus and nephritis. The pathogenic T cell clones thus reside within the V beta 8.3+ T cell population, which includes an expanded T cell clone described previously. Finally, UDA alters the production of autoantibodies in a sex-dependent manner.
In vivo monitoring of the death rate of artificial murine pulmonary micrometastases. (1978)

A system is described for direct monitoring of the death rate of artificial murine pulmonary microscopic metastases in vivo. Metastatic fibrosarcoma cells or benign connective tissue cells labeled with [125I]iododeoxyuridine were injected i.v. Comparison of the long-term radioactive decay rate of these two cell types in the lung permitted identification of the portion of the decay curve reflecting the initial period of micrometastasis development and growth. About 5% of the injected tumor cells were retained in the lung in micrometastasis, and their average death rate could be monitored by loss of radioactivity from the lung. Systemic methotrexate (75.0 mg/kg) was administered as a single dose 80 hr after injection of tumor cells at a time when micrometastases had not yet become vascularized. This treatment killed about 60% of the micrometases and suppressed the appearance of gross metastases at 14 days.
ChemInform Abstract: A NEW ENANTIOSELECTIVE TOTAL SYNTHESIS OF NATURAL VINCAMINE VIA AN INTRAMOLECULAR MANNICH REACTION OF AN SILYL ENOL ETHER (1977)

Abstract Kondensation des in mehreren Stufen (konventionelle Methoden) aus dem Aldehyd (I) erhältlichen Bromids (II) mit dem Dihydrocarbolin (III) gibt ein 1:1‐Gemisch der Racemate (IVa)/(Va) und (IVb)/(Vb); über eine reversible Mannich‐Reaktion [→(VI)] kann das unerwünschte Racemat (IVb)/(Vb) weiter in (IVa)/(Va) übergeführt werden; nachfolgende Racemattrennung (mit (H‐Äpfelsäure) und Überführung des "unnatürlichen" Enantiomeren (Va) in einem erneuten Recyclisierungsprozeß [Erhitzen von (Va) mit Toluolsulfonsäure ‐ (IVa)/(Va) + (IVb)/(Vb)] liefern schließlich das gewünschte Enantiomere (IVa) in 40%iger Ausbeute.
In situ Synthesis of Supramolecular Polymers: Finding the Right Conditions when Combining Covalent and Non‐Covalent Synthesis (2022)

Abstract The combination of covalent and non‐covalent synthesis is omnipresent in nature and potentially enables access to new materials. Yet, the fundamental principles that govern such a synthesis are barely understood. Here, we demonstrate how even simple reaction mixtures behave surprisingly complex when covalent reactions are coupled to self‐assembly processes. Specifically, we study the reaction behavior of a system in which the in situ formation of discotic benzene‐1,3,5‐tricarboxamide (BTA) monomers is linked to an intertwined non‐covalent reaction network including self‐assembly into helical BTA polymers. This system shows an unexpected phase‐separation behavior in which an interplay of reactant/product concentrations, side‐products and solvent purity determines the system composition. We envision that these insights can bring us one step closer to how to design the synthesis of systems in a combined covalent/non‐covalent fashion.
Comparison of Interlocking and Noninterlocking Intramedullary Nails in Bending and Torsion (1989)

Two types of interlocking intramedullary (IM) nails and a noninterlocked IM nail were tested in bending and torsion, to compare their flexural stiffness, and torsional stability in a femoral fracture model. A Grosse-Kempf IM nail with proximal and distal cortical interlocking screws, a Brooker-Wills IM nail with proximal interlocking screw and distal cancellous interlocking fins, and a Grosse-Kempf IM nail with no interlocking screws were tested. All IM nails had similar flexural stiffnesses. The interlocked Grosse-Kempf IM nail was most stable in torsion, followed by the interlocked Brooker-Wills IM nail. The noninterlocked Grosse-Kempf IM nail was least stable in torsion.
Transient switch-off of a 4H-SiC bipolar transistor from the deep-saturation mode (2017)

The transient switch-off of a bipolar 4H-SiC transistor from the deep-saturation mode is studied by performing 1D numerical simulation. Switch-off in the zero base current mode and in the mode of switching-off with a negative base current is examined. It is shown that at quite real values of the switching-off base current, the switch-off time can be made ~40 times shorter than the switch-off time at zero base current. The delay time can also be made substantially (several times) shorter. It is noted that, in the deep saturation mode in which the conductivity of the collector layer is highly modulated by minority carriers, the bipolar transistor can operate in the continuous mode at a rather high current density.
Transient effects at a velocity discontinuity in up/down filtering (2003)

The up/down convolutional velocity filter is commonly used in vertical seismic profiling to separate an upgoing from a downgoing wave field. In the neighborhood of a velocity discontinuity one expects to see transient effects. For a simple medium containing a single velocity discontinuity it is possible to derive an explicit formula for these transients. This analysis predicts that the transients decay at a rate inversely proportional to the distance from the velocity discontinuity. Despite the slow decay rate, these transients are found to be quite insignificant.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Remote Monitoring of Internal Bleeding Based on Magnetic Induction and Cellular Phone Technology: A Potential Application in Poor Regions in México (2010)

El objetivo de este estudio es introducir el fundamento teorico de un nuevo concepto en tecnologia medica basado en telefonia celular. El concepto fue concebido teniendo en mente las necesidades medicas de las regiones marginadas de Mexico y confronta el problema clinico que representan las hemorragias internas no detectadas a tiempo, tal problema es responsable de la muerte de una de cada cuatro mujeres que mueren durante el trabajo de parto asi como del 20% de muertes por accidentes traumaticos; incluyendo trauma craneoencefalico. El concepto planteado es posible debido a la amplia disponibilidad de tecnologia de telefonia celular en Mexico, la cual incluye a las regiones mas pobres en donde se carece de otro tipo de infraestructura basica. El principio biofisico de la tecnologia esta basado en la observacion de los cambios en las propiedades electromagneticas de tejido enfermo y hemorragias internas. Introducimos un nuevo paradigma de diagnostico medico en el que bobinas electromagneticas de bajo costo son empleadas en el sitio del paciente para adquirir datos volumetricos de un campo magnetico que es generado a traves del tejido u organo de interes. En lugar de procesar los datos con una computadora en el sitio remoto, los datos crudos son enviados via un telefono celular a una estacion central que procesa los datos crudos para toda una region o inclusive el pais entero. El diagnostico se envia en tiempo real al telefono celular en el lugar del paciente, reduciendo sustancialmente el costo de los dispositivos e incrementando la calidad de los diagnosticos. Se presentan los componentes y funcionalidad requerida para soportar el concepto de monitoreo a distancia mediante campos magneticos y tecnologia de telefonia celular
Experimental Study of Heat Transfer Augmentation in High Aspect-Ratio Channels Featuring Different Dimple Configurations (2015)

Transient liquid crystal technique was employed for experimental investigation of heat transfer distribution in high aspect ratio rectangular ducts featuring different dimple configurations. Four different dimple configuration shapes, viz. diamond, square, triangular and cylindrical, have been studied. This study also attempts to understand the dimple side wall heat transfer and correlate to the mechanisms of the flow inside the dimple. A brief numerical simulation study was also conducted to understand the vortex formation inside the dimples and how they affect the heat transfer on the dimple walls. Experiments were carried out at three different Reynolds number of 10,000, 16,000 and 21,000. Detailed normalized Nusselt number plots for different configurations has been presented. Pressure drop across each geometry was also recorded and a comparison of thermal–hydraulic performance is given. It was observed that heat transfer enhancement due to dimples was maximum for Re =10,000 case when compared to a flat plate scenario at the same Reynolds number. Thermal–hydraulic performance comparison showed that diamond and triangular dimples performed better due to lower pressure drop penalty.
Histology by Mass Spectrometry: Label‐Free Tissue Characterization Obtained from High‐Accuracy Bioanalytical Imaging (2010)

Next-generation imaging mass spectrometry of biological tissue on the cellular level shows excellent agreement with histochemical evaluation whilst providing a much higher discrimination capacity based on label-free molecular information (see image of a mouse urinary bladder section). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Computed Tomography in the Emergency Department Setting—Reply (2013)

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Antibody profiles and self‐reported symptoms to pollen‐related food allergens in grass pollen‐allergic patients from northern Europe (2005)

Sensitization to grass pollen alone is rare among grass pollen-allergic patients from northern Europe. The majority of patients are in addition sensitized to birch (Bet v 1), which seems to be closely related to their pollen-derived food allergy. The study highlights the advantage of using well-defined allergen molecules for the diagnosis of cross-reactivity between pollen and food allergens.
Triterpenoid Saponins in Oat Bran and Their Levels in Commercial Oat Products (2020)

Oats are commonly consumed as whole grains and generally considered as a healthy food. However, the bioactive compounds in oats have not been fully investigated. In this study, we reported for the first time the purification, structure elucidation, and chemical profile of the major triterpenoid saponins in oat bran as well as the quantification of the major triterpenoid saponins in commercial oat products. Thirteen triterpenoid saponins (<b>1</b>-<b>13</b>) were purified from oat bran. Their structures were characterized by analyzing their high-resolution mass spectrometry (MS), one-dimensional (1-D), and two-dimensional (2-D) NMR spectra. All of the purified triterpenoid saponins have been reported from oat bran for the first time, in which compounds (<b>1</b>-<b>8</b>) are newly discovered compounds and compound (<b>9</b>) is a new natural product. Using ultra-high-performance liquid chromatography with tandem mass spectrometry techniques, a complete profile of oat triterpenoid saponins was established, and the contents of the 13 purified triterpenoid saponins were quantitated in 19 different commercial oat products. The total levels of the 13 triterpenoid saponins varied from 1.77 to 18.20 μg/g in these 19 products, in which oat bran (11 samples) and oatmeal (three samples) had higher levels than cold oat cereal (five samples). Among the 11 commercial oat bran samples, the average total levels of the 13 triterpenoid saponins in the five sprouted oat samples are slightly higher than those in the regular oat bran products.
Detection and characteristics of microvascular obstruction in reperfused acute myocardial infarction using an optimized protocol for contrast-enhanced cardiovascular magnetic resonance imaging (2009)

Several cardiovascular magnetic resonance imaging (CMR) techniques are used to detect microvascular obstruction (MVO) after acute myocardial infarction (AMI). To determine the prevalence of MVO and gain more insight into the dynamic changes in appearance of MVO, we studied 84 consecutive patients with a reperfused AMI on average 5 and 104 days after admission, using an optimised single breath-hold 3D inversion recovery gradient echo pulse sequence (IR-GRE) protocol. Early MVO (2 min post-contrast) was detected in 53 patients (63%) and late MVO (10 min post-contrast) in 45 patients (54%; p = 0.008). The extent of MVO decreased from early to late imaging (4.3±3.2% vs. 1.8±1.8%, p<0.001) and showed a heterogeneous pattern. At baseline, patients without MVO (early and late) had a higher left ventricular ejection fraction (LVEF) than patients with persistent late MVO (56±7% vs. 48±7%, p<0.001) and LVEF was intermediate in patients with early MVO but late MVO disappearance (54±6%). During follow-up, LVEF improved in all three subgroups but remained intermediate in patients with late MVO disappearance. This optimised single breath-hold 3D IR-GRE technique for imaging MVO early and late after contrast administration is fast, accurate and allows detection of patients with intermediate remodelling at follow-up.
Sentifiers: Interpreting Vague Intent Modifiers in Visual Analysis using\n Word Co-occurrence and Sentiment Analysis (2020)

Natural language interaction with data visualization tools often involves the\nuse of vague subjective modifiers in utterances such as "show me the sectors\nthat are performing" and "where is a good neighborhood to buy a house?."\nInterpreting these modifiers is often difficult for these tools because their\nmeanings lack clear semantics and are in part defined by context and personal\nuser preferences. This paper presents a system called \\system that makes a\nfirst step in better understanding these vague predicates. The algorithm\nemploys word co-occurrence and sentiment analysis to determine which data\nattributes and filters ranges to associate with the vague predicates. The\nprovenance results from the algorithm are exposed to the user as interactive\ntext that can be repaired and refined. We conduct a qualitative evaluation of\nthe Sentifiers system that indicates the usefulness of the interface as well as\nopportunities for better supporting subjective utterances in visual analysis\ntasks through natural language.\n
Supplementary Figure S9 from A Clinical PET Imaging Tracer ([<sup>18</sup>F]DASA-23) to Monitor Pyruvate Kinase M2–Induced Glycolytic Reprogramming in Glioblastoma (2023)

&lt;p&gt;Imaging of IC-3&lt;/p&gt;