gebhart/patrepeval huggingface dataset:
Transgressive Segregation for Oleate Content in Three Soybean Populations (2005)

Increased oleate content of soybean [ Glycine max (L.) Merr.] oil may be useful for food and industrial applications requiring increased oxidative stability. The objective of this study was to determine if transgressive segregates for oleate content could be found in crosses between three mid‐oleate lines: FA22 from Iowa State University, N98‐4445A from the USDA‐ARS/North Carolina State University, and M23 from Saga University, Japan. Single‐cross populations of FA22 × M23, FA22 × N98‐4445A, and N98‐4445A × M23 were developed. Plants with significantly greater oleate than the highest oleate parent were observed in the three populations in the F 2 and F 3 generations. For the F 3:4 lines grown in Puerto Rico, there were four lines with significantly greater oleate than the highest parent in the cross FA22 × M23, one line in FA22 × N98‐4445A, and 27 lines in N98‐4445A × M23. The F 3:4 line with the greatest oleate content had 689 g kg −1 in the population FA22 × M23, 672 g kg −1 in FA22 × N98‐4445A, and 730 g kg −1 in N98‐4445A × M23 compared with 542 g kg −1 for FA22, 589 g kg −1 for N98‐4445A, and 583 g kg −1 for M23. Transgressive segregates from the populations should be useful as parents in a breeding program to develop cultivars with elevated oleate content.
Catalysis of the decomposition of hydrogen peroxide by a complex of iron(III) with a synthetic macrocyclic ligand (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalysis of the decomposition of hydrogen peroxide by a complex of iron(III) with a synthetic macrocyclic ligandAlexandra C. Melnyk, Nicholas K. Kildahl, Alan R. Rendina, and Daryle H. BuschCite this: J. Am. Chem. Soc. 1979, 101, 12, 3232–3240Publication Date (Print):June 1, 1979Publication History Published online1 May 2002Published inissue 1 June 1979https://pubs.acs.org/doi/10.1021/ja00506a017https://doi.org/10.1021/ja00506a017research-articleACS PublicationsRequest reuse permissionsArticle Views363Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Adapted Extended Baum-Welch transformations (2007)

The discrimination technique for estimating parameters of Gaussian mixtures that is based on the Extended Baum-Welch transformations (EBW) has had significant impact on the speech recognition community. &#13;\nIn this paper we introduce a general definition of a family of EBW transformations that can be associated with a weighted sum of updated and initial models. We compute a gradient steepness measurement for a family of EBW transformations that are applied to functions of Gaussian mixtures and demonstrate the growth property of these transformations. We consider EBW transformations of discriminative functions in which EBW controlled parameters are adapted to a gradient steepness measurement or to the likelihood of the data given the model. We present experimental results that show that adapted EBW transformations can significantly speed up estimating parameters of Gaussian mixtures and give better decoding results.
Neurodegeneration Within the Amygdala Is Differentially Induced by Opioid and HIV-1 Tat Exposure (2022)

Opioid use disorder (OUD) is a critical problem that contributes to the spread of HIV and may intrinsically worsen neuroHIV. Despite the advent of combined antiretroviral therapies (cART), about half of persons infected with HIV (PWH) experience cognitive and emotional deficits that can be exacerbated by opioid abuse. HIV-1 Tat is expressed in the central nervous system (CNS) of PWH on cART and is thought to contribute to neuroHIV. The amygdala regulates emotion and memories associated with fear and stress and is important in addiction behavior. Notwithstanding its importance in emotional saliency, the effects of HIV and opioids in the amygdala are underexplored. To assess Tat- and morphine-induced neuropathology within the amygdala, male Tat transgenic mice were exposed to Tat for 8 weeks and administered saline and/or escalating doses of morphine twice daily (s.c.) during the last 2 weeks of Tat exposure. Eight weeks of Tat exposure decreased the acoustic startle response and the dendritic spine density in the basolateral amygdala, but not the central nucleus of the amygdala. In contrast, repeated exposure to morphine alone, but not Tat, increased the acoustic startle response and whole amygdalar levels of amyloid-β (Aβ) monomers and oligomers and tau phosphorylation at Ser396, but not neurofilament light chain levels. Co-exposure to Tat and morphine decreased habituation and prepulse inhibition to the acoustic startle response and potentiated the morphine-induced increase in Aβ monomers. Together, our findings indicate that sustained Tat and morphine exposure differentially promote synaptodendritic degeneration within the amygdala and alter sensorimotor processing.
Model-Based Estimation of Vehicle Aerodynamic Drag and Rolling Resistance (2015)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Commercial vehicles transport the majority of the inland freight in US and a significant number of passengers. They are large fuel consumers as they operate a large number of hours per day, pulling heavy loads. The increasing fuel price and the Green House Gas emission regulation have provided a strong impetus for new technologies capable of improving the commercial vehicle fuel economy. Among others, optimized powertrain control can improve the vehicle fuel economy, particularly if it is based on accurate information about the instantaneous load demand. Furthermore, model-based online vehicle parameter estimator is critical for implementation of an adaptive vehicle controller.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;While vehicle mass estimation has been successfully demonstrated, rolling resistance and aerodynamic drag estimation has not been fully explored yet. This paper examines this problem using model-based approach with a supervisory data extraction scheme. The estimator uses signals from the standard vehicle CAN bus and accelerometer sensor to determine vehicle rolling resistance and aerodynamic drag coefficient on-the-fly. A supervisor monitors vehicle motion and extracts data only during events with high signal to noise ratio. The algorithm was tested using experimental data acquired from real-world driving cycles. The estimator is validated with a coast-down test and shows a sufficient accuracy in predicting the road load.&lt;/div&gt;&lt;/div&gt;
Impact of Gut Microbiota and Diet on the Development of Atherosclerosis in Apoe −/− Mice (2018)

Objective- To investigate the effect of gut microbiota and diet on atherogenesis. Approach and Results- Here, we investigated the interaction between the gut microbiota and diet on atherosclerosis by feeding germ-free or conventionally raised Apoe<sup>-/-</sup> mice chow or Western diet alone or supplemented with choline (which is metabolized by the gut microbiota and host enzymes to trimethylamine N-oxide) for 12 weeks. We observed smaller aortic lesions and lower plasma cholesterol levels in conventionally raised mice compared with germ-free mice on a chow diet; these differences were not observed in mice on a Western diet. Choline supplementation increased plasma trimethylamine N-oxide levels in conventionally raised mice but not in germ-free mice. However, this treatment did not affect the size of aortic lesions or plasma cholesterol levels. Gut microbiota composition was analyzed by sequencing of 16S rRNA genes. As expected, the global community structure and relative abundance of many taxa differed between mice fed chow or a Western diet. Choline supplementation had minor effects on the community structure although the relative abundance of some taxa belonging to Clostridiales was altered. Conclusions- In conclusion, the impact of the gut microbiota on atherosclerosis is dietary dependent and is associated with plasma cholesterol levels. Furthermore, the microbiota was required for trimethylamine N-oxide production from dietary choline, but this process could not be linked to increased atherosclerosis in this model.
Effect of Si on temperature dependence of non-propagation limit of small fatigue crack in a Fe-C alloy (2018)

Dynamic strain aging improves the non-propagation limit of a fatigue crack in ferritic iron alloys containing supersaturated carbon. However, upon increasing the test temperature, the non-propagation limit of the fatigue crack decreases owing to carbide precipitation. In this study, we present a guideline to improve high-temperature fatigue resistance in ferritic steels containing supersaturated carbon via Si addition that suppresses carbide formation. Compared with an Fe-0.017C binary alloy, an Fe- 0.016C-1.0Si alloy shows higher tensile strength at 293 and 433 K. The Si addition increased the fatigue limit at both temperatures as compared with that of the Fe–C binary alloy. The higher fatigue limit than that of the binary alloy at 293 K originated from the solid solution strengthening of Si, whereas the improved fatigue limit in Fe-0.016C-1.0Si at 433 K was attributed not only to the solution hardening, but also to the suppression of carbide formation at 433 K. With an increase in the temperature from 293 to 433 K, the reduction in the fatigue limit of the Fe-0.017C alloy was 65 MPa, while that for the Fe-0.016- 1Si alloy was only 40 MPa. These results indicated that the robustness against temperature can be improved by the addition of Si.
Spasm of small coronary arteries and ischemic myocardial injury induced by hypothalamic stimulation in the rat. (1987)

Electrical stimulation of the lateral hypothalamus resulted in electrocardiographic evidence of acute myocardial ischemia in 35% of normal adult rats under anesthesia. Mean arterial blood pressure was also elevated. Study of vascular corrosion casts disclosed that spasm of smaller branches of the coronary circulation, rather than the major epicardial arteries, was the main cause of the ischemic response. The histologic changes of the same experimental treatment in a separate group of animals revealed multiple focal areas of tissue damage throughout the myocardium, which were quantitatively assessed. The results may be relevant for the clinical problem of various forms of ischemic heart disease in which little evidence is found for organic (atherosclerosis) or dynamic (spasm) stenosis involving the major coronary arteries.
The Price of Malice: A Game-Theoretic Framework for Malicious Behavior in Distributed Systems (2009)

In recent years, game theory has provided insights into the behavior of distributed systems by modeling the players as utility-maximizing agents. In particular, it has been shown that selfishness causes many systems to perform in a globally suboptimal fashion. Such systems are said to have a large _price of anarchy_. In this article, we extend this field of research by allowing some players to be malicious rather than selfish. What, we ask, is the impact of malicious players on the system consisting of otherwise selfish players? In particular, we introduce the _price of malice_ as a measure that captures how much the system's efficiency degrades in the presence of malicious players, compared to a purely selfish environment. As a specific example, we analyze the price of malice of a game that models the containment of the spread of viruses. In this game, each player or node can choose whether to install antivirus software. Then, a virus starts from a random node and recursively infects all neighboring nodes that are not inoculated. We establish various results about this game. For instance, we quantify how much the presence of malicious players can deteriorate or—in case of highly risk-averse selfish players—improve the social welfare of the distributed system.
New Aromatic tert‐Amines for Application as Photoinitiator Components in Photocurable Dental Materials (2003)

Abstract A new type of aromatic tert ‐amine with a bisphenol A (BPA) skeleton has been prepared and applied as a photoinitiator (PI) component for enhancing photosensitivity in formulations of visible light curable dental polymers. Two N , N ‐dimethylamino (DMA) groups were incorporated into BPA diglycidyl ether to make 2,2‐bis[4‐(2‐hydroxy‐3‐( p ‐ N , N ‐dimethylaminobenzoyloxy)propyloxy)phenyl]propane (DMABPA). One or two (meth)acryloyl groups were reacted with the hydroxyl groups of DMABPA to obtain the polymerizable, BPA‐based tert ‐amines DMABPA‐1M (one methacrylate), DMABPA‐2M (two methacrylates), and DMABPA‐1A (one acrylate). The aromatic tert ‐amines and ethyl p ‐( N , N ‐dimethylamino)benzoate (EDMAB) were combined with a camphorquinone sensitizer to form a photoinitiating system, which was applied in photopolymerizations of dental resin formulations, based on Bis‐GMA as a matrix prepolymer, by visible light exposure. The photoconversion of the formulations using the new aromatic tert ‐amines as PIs was determined by the spectral changes in FTIR absorption intensities of methacrylate groups in cast films. High conversion (over 70%) resulted from photopolymerizations with (meth)acrylated DMABPA‐(1M, 2M, and 1A). magnified image
Issues in the management of prisoners infected with HIV-1: the King's College Hospital HIV prison service retrospective cohort study (2001)

Concern has been raised about the quality of health care provided to prisoners in England and Wales. 1 2 The management of prisoners infected with HIV-1 is challenging: a high proportion are injecting drug users, there are issues regarding confidentiality, and administering complex antiretroviral regimens may be difficult in prison. We reviewed our experience of providing specialist HIV care to prisoners between October 1994 and July 1999.

In October 1994, King's College Hospital was contracted to provide care to male prisoners with HIV-1 and sexually transmitted diseases at Wandsworth and Brixton prisons in south London. Prisoners access the service through self referral or referral by wing officers and prison healthcare workers.

Between October 1994 and July 1999 six prisoners were newly diagnosed as positive for antibodies to HIV-1 and 121 said that they had previously tested positive for antibodies to HIV-1. Of those 121, 75 were confirmed as positive for antibodies to HIV-1 and 25 tested negative for antibodies to HIV-1. Fourteen …
Results of the X-PECT study: A phase III randomized double-blind placebo-controlled study of perifosine plus capecitabine (P-CAP) versus placebo plus capecitabine (CAP) in patients (pts) with refractory metastatic colorectal cancer (mCRC). (2012)

LBA3501 The full, final text of this abstract will be available at abstract.asco.org at 12:01 AM (EDT) on Sunday, June 3, 2012, and in the Annual Meeting Proceedings online supplement to the June 20, 2012, issue of Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Sunday edition of ASCO Daily News.
Spatio-Temporal Vector of Locally Max Pooled Features for Action Recognition in Videos (2017)

We introduce Spatio-Temporal Vector of Locally Max Pooled Features (ST-VLMPF), a super vector-based encoding method specifically designed for local deep features encoding. The proposed method addresses an important problem of video understanding: how to build a video representation that incorporates the CNN features over the entire video. Feature assignment is carried out at two levels, by using the similarity and spatio-temporal information. For each assignment we build a specific encoding, focused on the nature of deep features, with the goal to capture the highest feature responses from the highest neuron activation of the network. Our ST-VLMPF clearly provides a more reliable video representation than some of the most widely used and powerful encoding approaches (Improved Fisher Vectors and Vector of Locally Aggregated Descriptors), while maintaining a low computational complexity. We conduct experiments on three action recognition datasets: HMDB51, UCF50 and UCF101. Our pipeline obtains state-of-the-art results.
Robust set-theoretic distributed detection in diffusion networks (2012)

We propose novel set-theoretic distributed adaptive filters for cooperative signal detection in diffusion networks, a problem that has been gaining attention owing to its application to cooperative cognitive radio networks. In the proposed method, nodes in a network detect the presence of a signal of interest by means of an inner product between the current term of a series and a known reference vector. Each term of the series is computed from information fusion among neighboring nodes and projections onto closed convex sets, which are constructed with a priori knowledge of the signal of interest and measurements obtained by nodes. In particular, we show that sets based on a priori knowledge are useful to decrease the communication overhead and to provide good detection performance. Our results are rigorous in the sense that no approximations are used to prove convergence properties. In particular, we show conditions to guarantee that the series converge to a point that can reliably identify the signal of interest. Furthermore, we also show that recent results in distributed optimization for dynamic systems can be used to derive algorithms where nodes exchange not only the current vectors of their sequences (as in previous distributed set-theoretic filters), but also side information that influences the above-mentioned sets.
1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis (2021)

Phenotypic whole cell high-throughput screening of a ∼150,000 diverse set of compounds against <i>Mycobacterium tuberculosis</i> (Mtb) in cholesterol-containing media identified 1,3-diarylpyrazolyl-acylsulfonamide <b>1</b> as a moderately active hit. Structure-activity relationship (SAR) studies demonstrated a clear scope to improve whole cell potency to MIC values of <0.5 μM, and a plausible pharmacophore model was developed to describe the chemical space of active compounds. Compounds are bactericidal <i>in vitro</i> against replicating Mtb and retained activity against multidrug-resistant clinical isolates. Initial biology triage assays indicated cell wall biosynthesis as a plausible mode-of-action for the series. However, no cross-resistance with known cell wall targets such as MmpL3, DprE1, InhA, and EthA was detected, suggesting a potentially novel mode-of-action or inhibition. The <i>in vitro</i> and <i>in vivo</i> drug metabolism and pharmacokinetics profiles of several active compounds from the series were established leading to the identification of a compound for <i>in vivo</i> efficacy proof-of-concept studies.
Pathogenesis, MicroRNA‐122 Gene‐Regulation, and Protective Immune Responses After Acute Equine Hepacivirus Infection (2021)

EqHV infection in horses typically has an acute resolving course, and the protective immune response lasts for at least a year and broadly attenuates subsequent infections. This could have important implications to achieve the primary goal of an HCV vaccine; to prevent chronicity while accepting acute resolving infection after virus exposure.
Investigation of protein secretion and secretion stress in Ashbya gossypii (2014)

This study provides the first insights into the secretion stress response of A. gossypii, as well as a basic understanding of its protein secretion potential, which is more similar to that of yeast than to that of other filamentous fungi. Contrary to what has been widely described for yeast and fungi, a conventional UPR was not observed in A. gossypii, but alternative protein quality control mechanisms enabled it to cope with secretion stress. These data will help provide strategies for improving heterologous protein secretion in A. gossypii.
Cellulose Nanofiber Biotemplated Palladium Composite Aerogels (2018)

Noble metal aerogels offer a wide range of catalytic applications due to their high surface area and tunable porosity. Control over monolith shape, pore size, and nanofiber diameter is desired in order to optimize electronic conductivity and mechanical integrity for device applications. However, common aerogel synthesis techniques such as solvent mediated aggregation, linker molecules, sol⁻gel, hydrothermal, and carbothermal reduction are limited when using noble metal salts. Here, we present the synthesis of palladium aerogels using carboxymethyl cellulose nanofiber (CNF) biotemplates that provide control over aerogel shape, pore size, and conductivity. Biotemplate hydrogels were formed via covalent cross linking using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) with a diamine linker between carboxymethylated cellulose nanofibers. Biotemplate CNF hydrogels were equilibrated in precursor palladium salt solutions, reduced with sodium borohydride, and rinsed with water followed by ethanol dehydration, and supercritical drying to produce freestanding aerogels. Scanning electron microscopy indicated three-dimensional nanowire structures, and X-ray diffractometry confirmed palladium and palladium hydride phases. Gas adsorption, impedance spectroscopy, and cyclic voltammetry were correlated to determine aerogel surface area. These self-supporting CNF-palladium aerogels demonstrate a simple synthesis scheme to control porosity, electrical conductivity, and mechanical robustness for catalytic, sensing, and energy applications.
SIRT1 Protects against α-Synuclein Aggregation by Activating Molecular Chaperones (2012)

α-Synuclein is a key molecule in the pathogenesis of synucleinopathy including dementia with Lewy bodies, Parkinson's disease, and multiple system atrophy. Sirtuins are NAD(+)-dependent protein deacetylases that are highly conserved and counter aging in lower organisms. We show that the life span of a mouse model with A53T α-synuclein mutation is increased by overexpressing SIRT1 and decreased by knocking out SIRT1 in brain. Furthermore, α-synuclein aggregates are reduced in the brains of mice with SIRT1 overexpression and increased by SIRT1 deletion. We show that SIRT1 deacetylates HSF1 (heat shock factor 1) and increases HSP70 RNA and protein levels, but only in the brains of mice with A53T and SIRT1 expression. Thus, SIRT1 responds to α-synuclein aggregation-induced stress by activating molecular chaperones to protect against disease.