gebhart/patrepeval huggingface dataset:
Abstract A90: Feedback activation of EGFR drives resistance to BRAF(V600E) inhibition in breast cancer. (2013)

Abstract Purpose: The BRAFV600E mutation has shown significant activity in the several tumor types, including breast, melanoma, and colorectal cancer. The selective inhibitor of BRAFV600, PLX4032 (vemurafenib), has shown clinical response in patients with BRAFV600Emelanoma, especially but not in 20-40% of patients despite the presence of a BRAFV600E. Thus, it is important to understand the molecular mechanisms of resistance to improve outcomes in patient with BRAF mutation. We aimed to investigate the cause of the limited therapeutic effect of PLX4032 in cancers harboring the mutant BRAFV600E gene. Experiment Design: We investigated the correlation between RTK pathway activation and sensitivity to PLX4032 in several types of cancer cell lines harboring the BRAFV600E. Cell lines were exposed to PLX4032 and pharmacologic inhibitors and in combination with each other to inhibit RTK signaling. Cell survival and apoptosis were measured using MTT assay, Annexin V/PI staining, and colony forming assay. Real-time PCR, Western blots were performed to determine possible mechanisms of resistance and predictors of synergy.Results: In a comparison with BRAFV600E cancer cells, we show that PLX4032-resistant MDA-MB breast cancer cells have the enhanced level of p-EGFR in the presence of PLX4032. PLX4032 treatment causes a rapid feedback activation of EGFR and up-regulation of AKT in MDA-MB cells, which supports continued proliferation in the presence of BRAFV600E inhibition. We show that EGFR activation acquired resistance to BRAF inhibition using EGFR inhibitor. Gefitinib, EGFR inhibitor, shows strong synergy with a BRAFV600E inhibitor in short-time and long-time treatment. In addition, we investigated that rapid feedback activation of EGFR regulates the expression of epithelial to mesenchymal transition (EMT) regulators by Real-time PCR, which resulted in high migratory potentials in invasion assay and wound healing assay. These results provide rational therapeutic strategies for clinical studies in this poor prognosis subtype of BRAFV600E inhibitor. Conclusions: Our data suggest that BRAFV600E mutant breast cancers, for which there are currently no targeted treatment options available, might benefit from combination therapy consisting of BRAF and EGFR inhibitors. Citation Information: Mol Cancer Ther 2013;12(11 Suppl):A90. Citation Format: Yj Yang, HJ Na, Ws Kim, JP Bong, SJ Beak, Jw Kim, Jk Park, Hj Hong, Dy Shin, Jh Kwon, Ej Lee, Yw Koh, Ec Choi. Feedback activation of EGFR drives resistance to BRAF(V600E) inhibition in breast cancer. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr A90.
A WBAN-based System for Health Monitoring at Home (2006)

This paper describes a prototype system for continual health monitoring at home. The system consists of an unobtrusive wireless body area network (WBAN) and a home health server. The WBAN sensors monitor user's heart rate and locomotive activity and periodically upload time-stamped information to the home server. The home server may integrate this information into a local database for user's inspection or it may forward the information further to a medical server. The prototype may be used for ambulatory monitoring of patients undergoing cardiac rehabilitation or for monitoring of elderly at home by informal caregivers.
Comparison of the proteins of bovine and ovine parainfluenza-3 viruses. (1994)

Bovine and ovine parainfluenza-3 (PI-3) virus proteins were compared using polyclonal and monoclonal antibodies in western blot analysis. Eight proteins ranging in molecular weight (MW) from 14 kD to 190 kD of bovine PI-3 virus were demonstrated in this study. The 14 kD MW protein has not been previously described for bovine PI-3 virus. Western blot analysis of ovine PI-3 virus using homologous serum produced 7 bands ranging in MW from 12 kD to 190 kD described for the first time in this paper. Using rabbit polyclonal antibodies against bovine PI-3 virus a 160 kD MW protein was demonstrated in the bovine virus strain, but not in the ovine PI-3 virus strain and a protein band appeared in the ovine PI-3 virus strain at a MW of 23 kD but not in the bovine PI-3 virus strain. Using lamb polyclonal antibodies to ovine PI-3 virus against the homologous virus, 6 protein bands were visible with a MW range from 12 kD to 175 kD; for bovine PI-3 virus 5 protein bands were resolved. There was a difference observed in the mobility of the 120 kD MW protein for ovine PI-3 viral protein but not for the bovine PI-3 viral protein. Differences were observed for ovine PI-3 viral protein at the level of the 12 kD MW protein whereas the lowest detected band for the bovine PI-3 viral protein was 37 kD MW. The monoclonal antibodies prepared against bovine PI-3 virus produced 3 distinct protein bands. Two bands of MW 110 and 140 kD were identical for both viruses whereas the third band for bovine PI-3 virus was 37 kD MW and that for ovine PI-3 virus was 55 kD MW.
Role of glucagon in intestinal hyperemia associated with early experimental diabetes mellitus (1988)

The role of glucagon as a blood-borne mediator of the intestinal hyperemia associated with experimental diabetes mellitus was assessed in anesthetized fasted (18-24 h) rats 4 wk after the administration of streptozotocin (65 mg/kg body wt) or its vehicle. Selective removal of pancreatic glucagon from the circulation was accomplished by the intravenous administration of a highly specific glucagon antiserum. Blood flow to the gastrointestinal tract and kidneys was measured with radioactive microspheres using the reference sample technique. Blood flows were increased by at least 60% in each segment of the gastrointestinal tract of diabetic animals compared with control rats. Glucagon antiserum had no effect on blood flows in the gastrointestinal tract of control animals. However, the antiserum produced a significant reduction in blood flow to the stomach (26%), duodenum (25%), jejunum (12%), and kidneys (16%) in diabetic rats. There was no change in blood flow to the ileum or colon of diabetic animals with antiserum administration. The results of this study support the hypothesis that glucagon mediates a portion of the hyperemia noted in the stomach, duodenum, and jejunum. However, glucagon does not appear to play a role in the genesis of the hyperemia noted in more distal segments of the gastrointestinal tract (ileum and colon). A possible role for glucagon in the maintenance of renal blood flow in diabetic rats is suggested.
Converting Kinetic Energy in Small Watercourses Using Direct Drive Generators (2004)

Tidal currents, ocean currents and unregulated watercourses are all large sources of energy that can be converted into electricity. Several technical and economical solutions within this research area have been demonstrated. In literature there exists two different turbine types, horizontal and vertical axis. The present paper focuses on the design of a permanent magnetized generator directly coupled to a vertical axis turbine. The proposed theoretical concept is adapted to data measurements regarding water current velocities and flow profiles from a Swedish watercourse. A high electromagnetic efficiency of 90% is obtained.
Partially Reacted Substructures Method for Thermoset Epoxies Studied Using Molecular Dynamics Simulations (2015)

We employed the “partially reacted substructure (PRS)” method to enhance the material properties of the diglycidyl ether of bisphenol A (DGEBA) epoxy thermosets. This method involves first partially curing DGEBA with a small amount of poly(oxypropylene)diamine (POPDA) and then adding DGEBA and diethyltoluenediamine (DETDA) to continue to a fully cured sample. PRS-induced DGEBA-DETDA/POPDA 2:1 epoxy-amine stoichiometric samples have consistently higher Tg’s and glassy state densities than samples created using one-step cure of a blend of DGEBA with both DETDA and POPDA. PRS-induced samples were found to be twice as tough as non-PRS samples. Because the compositions are identical, differences observed must arise from differences in the network isomers formed by the two curing protocols and the resulting differences in packing and intermolecular interactions. Molecular dynamics (MD) simulations were carried out to better understand these phenomena. The density and glass transition temperature in the simulations are in quantitative agreement with the experimental results. One reason for this Tg increase in PRS-induced samples may be related to the pendant methyl groups on POPDA, as illustrated using radial distribution functions (RDF’s) computed from the MD simulation trajectories. Methyl-methyl RDF’s for non-PRS samples did not differ significantly from those of the prepolymerized liquid, but the methyl-methyl RDF’s for the PRS-samples showed stronger methyl-methyl correlation at all distances, signifying better intra- and intermolecular POPDA packing. This results in lower POP backbone flexibility in the PRS samples and consequently higher Tg’s relative to the non-PRS samples. Further simulations aim to ultimately focus on the ductility enhancement conferred by PRS.
Vanillin: More than a flavouring agent—a potent antioxidant (1989)

Abstract Vanillin is probably the most widely used flavouring agent for sweet foods such as biscuits, desserts, ice cream etc. It has been argued, however, that vanillin is used not only as a flavouring ingredient but also to mask undesirable off‐flavours developed during storage by products susceptible to oxidative degradation. This paper shows that vanillin not only adds its pleasant flavour note, but also acts as an antioxidant in complex foods containing polyunsaturated fatty acids. It is shown that the keeping quality of precooked dried cereal flakes was considerably increased by the addition of 0·01–0·5% (on a dry matter basis) of vanillin.
Phase I study of the safety and tolerability of the Exportin 1 (XPO1) inhibitor Selinexor (SXR) in Asian patients (pts) with advanced solid cancers. (2015)

2542 Background: SXR is an orally administered potent XPO1 inhibitor that forces nuclear retention and activation of multiple tumor suppressor proteins resulting in tumor cell death. SXR was evaluated in Asian pts with advanced cancer to assess safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PDn) and efficacy. Methods: SXR dose escalation was initiated in a 3+3 design on a twice weekly continuous 28 day cycle, schedule 1 (S1), but stopped due to persistent drug-related adverse events (AEs). Two further schedules were explored: S2, once weekly continuously every 28 days, and S3, twice weekly for 2 weeks of a 21 day cycle. Serial tumor biopsies were performed pre- and 6-8 weeks post SXR. RECIST/ Cheson lymphoma criteria for response was evaluated every 2 cycles. Results: 18 pts (median age 61 yrs; ECOG 0-1) received escalating doses of SXR across 3 schedules. In S1 no dose-limiting toxicity (DLT) occurred at expanded dose-level (DL) 1 (40mg/m2, 6pts), but was stopped due to persistent ≥ G2 AEs (fatigue [50%], hyponatremia [50%], anorexia [17%]) post cycle 1. In S2, at DL1 (50mg/m2, 3pts) and DL2 (60mg/m2, 3pts), G1/2 AEs were hyponatremia (67%), nausea (33%), fatigue (50%) and anorexia (50%) with no ≥ G3 AEs. In S3, at DL1 (40mg/m2, 3 pts) and DL2 (50mg/m2, 3 pts); AEs were hyponatremia G1/2 (50%) and ≥ G3 (50%), nausea G1/2 (33%) and ≥ G3 (17%), fatigue G1/2 (67%) and ≥ G3 (33%), anorexia G1/2 (67%). No DLTs occurred in S2/S3. PK analysis demonstrated SXR exposure with no accumulation and comparable half-life and clearance when compared with non-Asian pts. At 40mg/m2, AUC0-inf (5,222 ng*h/mL) was comparable to the anti-tumor exposure observed in mice and dogs. Mean Tmax = 2hrs and T1/2 = 5.7 hrs. Reduced cellularity and proliferation with increased fibrosis and apoptosis was seen in tumors post-SXR administration. Of 13 evaluable pts, best responses were PR in 2pts with refractory diffuse-large B-cell lymphoma, SD in 8 pts (colorectal [n = 2], pancreas, squamous cell tongue, non-small cell lung, ovarian and hepatocellular carcinoma [n = 2]), and PD in 3pts. Conclusions: Dose-escalation of SXR is ongoing on S2 and S3 with more G3 AEs seen in S3. Promising antitumor activity was observed. Clinical trial information: NCT02078349.
Initial Growth Kinetics of Luminescent Quantum Clusters of Silver within Albumin Family Protein Templates (2015)

We probed the initial growth kinetics of luminescent quantum clusters of silver (AgQCs) within two albumin family proteins, bovine serum albumin (BSA) and ovalbumin (Ova). Shorter time scale (seconds to minutes) growth of AgQCs monitored using real time photoluminescence spectroscopy has shown that, at lower concentrations of Ag+, only unstable QCs were formed. The major role of basic pH in the synthesis was not only to facilitate Ag+-BSA conjugation but also to provide well dispersed medium for controlled nucleation of QCs. Increase in the concentration of NaBH4 affects growth kinetics greatly and leads to increase in the growth rate of AgQCs; but for NaBH4 concentrations higher than the optimum value, growth rate becomes constant. Precise measurements have shown that excitation and emission of AgQCs exhibit linear red-shift with the increasing concentration of NaBH4 whereas protein excitation remains constant. Similar results were observed for both the proteins, Ova and BSA. We believe that various insights provided by this study will be helpful for further improvements in the synthetic methodology and applications of protein protected AgQCs.
Parametric analyses of vapor-anode, multitube AMTEC cells for Pluto/Express mission (1998)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Mohamed S. El-Genk, Jean-Michel Tournier; Parametric analyses of vapor-anode, multitube AMTEC cells for Pluto/Express mission. AIP Conf. Proc. 15 January 1998; 420 (1): 1461–1470. https://doi.org/10.1063/1.54774 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
El Outsourcing en la dinámica de sistemas hacia mercados extranjeros (2014)

Este trabajo recopila literatura academica relevante sobre estrategias de entrada y metodologias para la toma de decision sobre la contratacion de servicios de Outsourcing para el caso de empresas que planean expandirse hacia mercados extranjeros. La manera en que una empresa planifica su entrada a un mercado extranjero, y realiza la consideracion y evaluacion de informacion relevante y el diseno de la estrategia, determina el exito o no de la misma. De otro lado, las metodologias consideradas se concentran en el nivel estrategico de la piramide organizacional. Se parte de metodos simples para llegar a aquellos basados en la Teoria de Decision Multicriterio, tanto individuales como hibridos. Finalmente, se presenta la Dinamica de Sistemas como herramienta valiosa en el proceso, por cuanto puede combinarse con metodos multicriterio.
Predictive Score for Identifying Survival and Recurrence Risk Profiles in Patients Undergoing Ventricular Tachycardia Ablation (2018)

Our study is the first to derive and validate a decisional model that provides estimates of VT recurrence and mortality with an effective classification tree. Preprocedure risk stratification could help optimize periprocedural and postprocedural care.
The utility of three-dimensional models in complex microsurgical reconstruction (2020)

Use of 3D print model improves accuracy of preoperative planning and reduces flap harvest time with similar postoperative complications in complex microsurgical reconstruction.
5G Network (2020)

NTT DOCOMO launched its fifth-generation mobile communications system (5G) commercial service in March 2020 achieving early provision and stable quality by making maximum use of functions and coverage provided by LTE (Long Term Evolution).This article describes the development of radio base-station equipment and core network equipment for providing the 5G commercial service.
Fabrication of 3D polymer photonic crystals for near-IR applications (2008)

Photonic crystals[1, 2] have stirred enormous research interest and became a growing enterprise in the last 15 years. Generally, PhCs consist of periodic structures that possess periodicity comparable with the wavelength that the PhCs are designed to modulate. If material and periodic pattern are properly selected, PhCs can be applied to many applications based on their unique properties, including photonic band gaps (PBG)[3], self-collimation[4], super prism[5], etc. Strictly speaking, PhCs need to possess periodicity in three dimensions to maximize their advantageous capabilities. However, many current research is based on scaled two-dimensional PhCs, mainly due to the difficulty of fabrication such three-dimensional PhCs. Many approaches have been explored for the fabrication of 3D photonic crystals, including layer-by-layer surface micromachining[6], glancing angle deposition[7], 3D micro-sculpture method[8], self-assembly[9] and lithographical methods[10-12]. Among them, lithographic methods became increasingly accepted due to low costs and precise control over the photonic crystal structure. There are three mostly developed lithographical methods, namely X-ray lithography[10], holographic lithography[11] and two-photon polymerization[12]. Although significant progress has been made in developing these lithography-based technologies, these approaches still suffer from significant disadvantages. X-ray lithography relies on an expensive radiation source. Holographic lithography lacks the flexibility to create engineered defects, and multi-photon polymerization is not suitable for parallel fabrication. In our previous work, we developed a multi-layer photolithography processes[13, 14] that is based on multiple resist application and enhanced absorption upon exposure. Using a negative lift-off resist (LOR) and 254nm DUV source, we have demonstrated fabrication of 3D arbitrary structures with feature size of several microns. However, severe intermixing problem occurred as we reduced the lattice constant for near-IR applications. In this work, we address this problem by employing SU8. The exposure is vertically confined by using a mismatched 220nm DUV source. Intermixing problem is eliminated due to more densely crosslinked resist molecules. Using this method, we have demonstrated 3D "woodpile" structure with 1.55&mu;m lattice constant and a 2mm-by-2mm pattern area.
Fabrication of ion-induced carbon-cobalt nanocomposite fibers: Effect of cobalt supply rate (2010)

Graphite surfaces were irradiated by Ar <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> ions at 1 keV with a simultaneous Co supply at room temperature. Various kinds of carbon nanocomposites, such as nanocones with and without nanofibers (NFs) on top, nanorods and bean-like nanoprotrusions, formed depending on Co supply rates. The NFs, ∼1.5 µm in average length, grew on the top of the nanocones at Co supply rate of 1.0 nm/min, and with increasing the Co supply rate the formation of nanoprotrusions without NFs became prominent. As confirmed by energy-dispersive X-ray analysis, NFs and nanoprotrusions were surely composed of C and Co.
Novel non-invasive contrast agents for virtual histology and 3D quantification of soft tissues (2016)

status: Published
Hybrid array fed reflector antenna solution for broadband satellite communications (2017)

An hybrid array fed reflector antenna solution is described in this paper, combining a focused geometry in one plane and an imaging (defocused) geometry in the orthogonal plane. This doubly curved reflector geometry can be combined with a stack of linear phased arrays, introducing some re-configurability at a moderate cost when compared to more conventional imaging reflector solutions using planar phased arrays. A simple analytical formulation is derived to define the proposed doubly curved surface and numerical results are presented for a multiple beam mission at Ka-band. This hybrid antenna solution is considered of interest for broadband payloads to be embarked on future communication satellites.
Combining analytical technique and randomized algorithm in safety verification of stochastic hybrid systems (2014)

We consider the problem of probabilistic safety verification for stochastic hybrid systems. In particular, we propose a method that combines two existing approaches, namely, analytical techniques and randomized algorithms. Analytical techniques, such as using stochastic approximate bisimulation, are able to handle non-deterministic initial states. However, their practical applicability is limited to relatively simple stochastic dynamics. On the other hand, randomized algorithms are able to handle more complex dynamics. However, it typically requires running a large number of simulations, and cannot be used for non-deterministic initial states. Our combined approach basically uses an analytical technique when the stochastic dynamics is simple, and switches to a randomized algorithm when the dynamics is nonlinear. The main idea is that by using the analytical technique, we can bound the gaps between the probability density functions corresponding to the family of non-deterministic initial states. This, in turn, enables randomized algorithms that provide upperand lower-bounds on the safety and unsafety probabilities. We illustrate our approach with an example from air traffic management.
Overlapping, but Not Identical, Sites Are Involved in the Recognition of C3bi, Neutrophil Inhibitory Factor, and Adhesive Ligands by the αMβ2 Integrin (1996)

The alphaMbeta2 (CD11b/CD18, Mac-1) integrin receptor binds numerous ligands, including neutrophil inhibitory factor (NIF), C3bi, and certain immobilized protein substrates, represented by denatured ovalbumin. These ligands share no obvious structural similarities, yet their interactions with receptor are inhibited by NIF and involve the I domain, a stretch of approximately 200 amino acids in the alphaM subunit. Recombinant wild-type and mutant forms of alphaMbeta2 have been used to compare the recognition requirements of these ligands. The various constructs were expressed efficiently on the surface of human embryonic kidney 293 cells and formed alpha.beta heterodimeric complexes. The wild-type transfectants bound the three ligands in a similar fashion to naturally occurring alphaMbeta2. NIF inhibited these interactions, and deletion of the D248PLGY from within the I domain abolished binding of all three ligands, suggesting an overlapping recognition specificity. A single point mutation of Ser138 to Ala in the beta2 subunit abolished C3bi binding and cell adhesion but did not affect NIF binding. A switch of the R281QELNTI sequence in helix 6 of the alphaM I domain to the corresponding sequence in the I domain of the alphaL (QETLHKF) subunit completely abrogated adhesion while not affecting C3bi and NIF binding. The two mutant receptors also did not support activation-dependent adhesion to fibrinogen. Thus, the contact sites for NIF, C3bi, and adhesive proteins, represented by denatured ovalbumin and fibrinogen, in alphaMbeta2 are overlapping but not identical.