gebhart/patrepeval huggingface dataset:
Diplatinum(ii)-coordinated polyoxotungstate: synthesis, molecular structure, and photocatalytic performance for hydrogen evolution from water under visible-light irradiation (2012)

The synthesis and molecular structure of a monomeric diplatinum(II) complex composed of mono-lacunary α-Keggin polyoxometalate is described. The polyoxometalate, Cs(3)[α-PW(11)O(39){cis-Pt(NH(3))(2)}(2)]·8H(2)O (Cs-1), afforded by a stoichiometric reaction of mono-lacunary Keggin polyoxotungstate with cis-diamminedichloroplatinum(ii) in water, followed by crystallization from water, was obtained as analytically pure, homogeneous, yellow crystals. The compound Cs-1 was characterized by elemental analysis, thermogravimetric/differential thermal analysis (TG/DTA), Fourier transform infrared (FTIR) and UV-visible spectroscopy, solution (1)H and (31)P nuclear magnetic resonance (NMR), and X-ray crystallography. The single-crystal X-ray structure analysis revealed that the two cis-platinum(ii) moieties, [cis-Pt(NH(3))(2)](2+), were coordinated each to two oxygen atoms in a mono-vacant site of [α-PW(11)O(39)](7-) with asymmetric configuration, resulting in an overall C(1) symmetry. Furthermore, hydrogen evolution from an EDTA·2Na (ethylenediamine tetraacetic acid disodium salt) aqueous solution under visible-light irradiation (≥400 nm) was achieved by using polyoxoanion 1 and titanium dioxide.
Flt3 Ligand Promotes the Generation of a Distinct CD34+Human Natural Killer Cell Progenitor That Responds to Interleukin-15 (1998)

Interleukin-15 (IL-15) is produced by human bone marrow (BM) stromal cells and can induce CD34+ hematopoietic progenitor cells (HPCs) to differentiate into CD56+CD3−natural killer (NK) cells in the absence of stromal cells. IL-15 mediates its effects by signaling through the β and γcchains of the IL-2/15 receptor (R). The c-kit ligand (KL), also produced by stromal cells, enhances the expansion of NK cells from CD34+ HPCs in the presence of IL-15, but alone has no ability to differentiate NK cells. Mice deficient in KL do not appear to have a quantitative deficiency in NK cells, suggesting that other stromal cell factors may contribute to NK cell expansion. Flt3 ligand (FL) is also produced by BM stromal cells and has homology with KL. Furthermore, mice with a targeted disruption of the FL gene have reduced numbers of NK cells. We evaluated here the effects of FL on human NK cell development and expansion from CD34+ HPCs. Like KL, FL significantly enhanced the expansion of NK cells from CD34+ HPCs in the presence of IL-15, compared with IL-15 alone. However, FL alone had no effect on NK cell differentiation. We therefore explored the mechanism by which FL promotes IL-15–mediated NK cell development. FL was found to induce IL-2/15Rβ (CD122) expression on CD34bright HPCs. The CD34brightCD122+ cell coexpressed CD38, but lacked expression of CD7, CD56, NK cell receptors (NKRs), or cytotoxic activity in the absence of IL-15. Using limiting dilution analysis in the presence of IL-15 alone, we demonstrated that the FL-induced CD34brightCD122+ HPCs had an NK cell precursor frequency 20- to 60-fold higher than the CD34dim/negCD122− HPCs and 65- to 235-fold higher than fresh CD34+ HPCs. KL had similar effects as FL, but induced a significantly lower percentage of CD34brightCD122+ cells (P ≤ .01). Both FL and KL also increased IL-15R transcript in CD34+ HPCs. Culture of CD34+ HPCs in FL or KL, followed by culture in IL-15 alone, induced expression of both C-type lectin and Ig-superfamily NKRs on CD56+ cells. These data collectively support a role for FL in early human NK cell development. FL or KL generate a unique CD34brightCD122+CD38+ human NK cell intermediate from CD34+ HPCs that lacks NK features yet is IL-15–responsive. IL-15 is then required for the induction of CD56 and NKRs, LGL morphology, cytotoxic activity, and the ability to produce abundant cytokines and chemokines.
Improving data-flow analysis with path profiles (with retrospective) (1998)

Intensity inhomogeneities and different types/levels of image noise are the two major obstacles to accurate image segmentation by region-based level set models. To provide a more general solution to these challenges, we propose a novel segmentation model that considers global and local image statistics to eliminate the influence of image noise and to compensate for intensity inhomogeneities. In our model, the global energy derived from a Gaussian model estimates the intensity distribution of the target object and background; the local energy derived from the mutual influences of neighboring pixels can eliminate the impact of image noise and intensity inhomogeneities. The robustness of our method is validated on segmenting synthetic images with/without intensity inhomogeneities, and with different types/levels of noise, including Gaussian noise, speckle noise, and salt and pepper noise, as well as images from different medical imaging modalities. Quantitative experimental comparisons demonstrate that our method is more robust and more accurate in segmenting the images with intensity inhomogeneities than the local binary fitting technique and its more recent systematic model. Our technique also outperformed the region-based Chan–Vese model when dealing with images without intensity inhomogeneities and produce better segmentation results than the graph-based algorithms including graph-cuts and random walker when segmenting noisy images.
Ternary Complexes Comprising Polyphosphoramidate Gene Carriers with Different Types of Charge Groups Improve Transfection Efficiency (2004)

To understand the influence of charge groups on transfection mediated by polymer complexes, we have synthesized a series of biodegradable and cationic polyphosphoramidates (PPAs) with an identical backbone but different side chains. Our previous study showed that PPA with a spermidine side chain (PPA-SP) showed high transfection efficiency in culture, whereas PPAs with secondary, tertiary, and quaternary amino groups were significantly less efficient. To investigate whether the coexistence of 1 degrees amino charge groups with 3 degrees and 2 degrees amino charge groups in the DNA/polymer complexes would enhance their transfection efficiency, we evaluated a ternary complex system containing DNA and PPAs with 1 degrees amino groups (PPA-SP) and 3 degrees amino groups (PPA-DMA) and a quaternary complex system containing DNA and PPAs with 1 degrees and 2 degrees and 3 degrees amino groups (PPA-EA/PPA-MEA/PPA-DMA), respectively. Ternary complexes mediated 20 and 160 times higher transfection efficiency in COS-7 cells than complexes of DNA with PPA-SP or PPA-DMA alone, respectively. Similarly, quaternary complexes exhibited 8-fold higher transfection efficiency than PPA-EA/DNA complexes. The mechanism of enhancement in transfection efficiency by the mixture carriers appears to be unrelated to the particle size, zeta potential, or DNA uptake. The titration characterization and the transfection experiments using a proton pump inhibitor suggest that the enhancement effect is unlikely due to the slightly improved buffering capacity of the mixture over PPA-SP. This approach represents a simple strategy of developing polymeric gene carriers and understanding the mechanisms of polymer-mediated gene transfer.
Pharmacokinetic parameters for D3 from noncompartmental analysis of brain. (2015)

&lt;p&gt;For abbreviations see &lt;a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0128553#sec002" target="_blank"&gt;methods&lt;/a&gt; section.&lt;/p&gt;&lt;p&gt;Pharmacokinetic parameters for D3 from noncompartmental analysis of brain.&lt;/p&gt;
On the Analysis and the Mitigation of Power Supply Noise and Power Distribution Network Impedance Variation for Scan-Based Delay Testing Techniques (2018)

In this paper, we analyze the impact of the power supply noise and the power distribution network (PDN) impedance variation on the timing margin in both modes for ICs with multiple clock domains. We investigate the so-called intermodulation products (IMPs). We show that IMPs are mainly induced by the dependent nature of the transistors. We also provide experimental results showing that scan-based delay testing can be optimistic with respect to the mission mode for maximum achievable nominal frequency prediction, even at lower clock frequencies. We also show that IMPs can induce timing margin fluctuations that can be larger than that of the ones induced by the voltage droop in the test mode. Using an improved HSpice simulation model of a PDN validated by experimental results, we also quantify the timing margin variation due to power noise in the test mode as a function of the clock frequency, including the so-called clock stretching phenomenon. Finally, we propose a robust test signal scheme for multiple clock domain chips. The simulation results reveal that this scheme is less sensitive to PDN impedance variation than that of the most popular existing test schemes, and that it provides timing margins closer to those obtained in the mission mode.
Inorganic composite materials in Japan: Status and trends (1989)

Japan's high performance composite research activities and applications are reviewed by six authors who teamed as a study group in September 1988 to assess selected research areas of composite activities. The article focuses on metal and ceramic matrix composites and high temperature ceramic reinforcements, excluding carbon fibers and polymer matrix composites. It is the intention of the article to capture the current trends and scientific accomplishments of university, government research laboratories and, to a lesser extent, selected industrial laboratories in the research areas. In addition, an interpretation and forecast of future directions is considered in each topic area based on current activities and perceived trends.
A configurable architecture to limit wakeup current in dynamically-controlled power-gated FPGAs (2012)

A dynamically-controlled power-gated (DCPG) FPGA architecture has recently been proposed to reduce static energy dissipation during idle periods. During a power mode transition from an off state to on state, the wakeup current drawn from power supplies causes a voltage droop on the power distribution network of a device. If not handled appropriately, this current and the associated voltage droop could cause malfunction of the design and/or the device. In DCPG FPGAs, the amount of wakeup current is not known beforehand as the structures of power-gated modules are application dependent; thus, a configurable solution is required to handle wakeup current. In this paper we propose a programmable wakeup architecture for DCPG FPGAs. The proposed solution has two levels: a fixed intra-region level and a configurable inter-region level. The architecture ensures that a power-gated module can be turned on such that the wakeup current constraints are not violated. We study the area and power overheads of the proposed solution. Our results show that the area overhead of the proposed inrush current limiting architecture is less than 2% for a power gating region of size 3x3 or 4x4 tiles, and the leakage power saved is more than 85% in a region of size 4x4 tiles.
Novel Inhibitors of Neuronal Nitric Oxide Synthase with Potent Antioxidant Properties. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
ALL-1 interacts with unr, a protein containing multiple cold shock domains. (1996)

The ALL-1 gene is involved in human acute leukemia through chromosome translocations and fusion to partner genes, or through partial tandem duplications. ALL-1 is the human homologue of Drosophila trithorax which transregulates the homeotic genes of the Antennapedia and bithorax complexes controlling body segment identity. ALL-1 encodes a very large protein of 3968 amino acids which presumably interacts with many proteins. Here we applied yeast two hybrid screening to identify proteins interacting with the N-terminal segment of ALL-1. One protein obtained in this way was the product of the unr gene. This protein consists of multiple repeats homologous to the cold shock domain (CSD), a motif common to some bacterial and eukaryotic nucleic acids-binding proteins. The minimal region on unr required for the interaction with ALL-1 included two CSD and two intervening polypeptides. The interaction was confirmed by in vitro binding studies, and by coimmunoprecipitation from COS cells overexpressing the relevant segments of the two proteins. These results suggest that unr is involved in an interaction of ALL-1 with DNA or RNA.
Synthesis and selection of DCT algorithms using behavioral synthesis-based algorithm space exploration (2002)

Numerous fast algorithms for the discrete cosine transform (DCT) have been proposed in image and video processing literature. Until recently, it has been difficult to compare different DCT algorithms and select one which is best suited for implementation under a given set of design goals and constraints. In this paper, we propose an approach for design space exploration at the algorithm and behavioral levels using high level synthesis tools. In particular, we study and compare the following nine DCT algorithms: Lee's, Wang's, DIT, DFT, QR, Givens, Arai, MCM, and direct algorithm. The main conclusion of this study is that the best choice among fast DCT algorithms depends on a particular set of design goals and constraints. Another important conclusion is that for almost all sets of implementation goals and constraints more than an order of magnitude improvement can be achieved using algorithm and behavioral design space exploration.
A New Acoustic Emission Sensor Based Gear Fault Detection Approach (2013)

In order to reduce wind energy costs, prognostics and health management (PHM) of wind turbine is needed to ensure the reliability and availability of wind turbines. A gearbox is an important component of a wind turbine. Therefore, developing effective gearbox fault detection tools is important to the PHM of wind turbine. In this paper, a new acoustic emission (AE) sensor based gear fault detection approach is presented. This approach combines a heterodyne based frequency reduction technique with time synchronous average (TSA) and spectrum kurtosis (SK) to process AE sensor signals and extract features as condition indictors for gear fault detection. Heterodyne technique commonly used in communication is first employed to preprocess the AE signals before sampling. By heterodyning, the AE signal frequency is down shifted from several hundred kHz to below 50 kHz. This reduced AE signal sampling rate is comparable to that of vibration signals. The presented approach is validated using seeded gear tooth crack fault tests on a notational split torque gearbox. The approach presented in this paper is physics based and the validation results have showed that it could effectively detect the gear faults.
Age-Aware Stochastic Hybrid Systems: Stability, Solutions, and Applications (2021)

In this paper, we analyze status update systems modeled through the Stochastic Hybrid Systems (SHSs) tool. Contrary to previous works, we allow the system's transition dynamics to be polynomial functions of the Age of Information (AoI). This dependence allows us to encapsulate many applications and opens the door for more sophisticated systems to be studied. However, this same dependence on the AoI engenders technical and analytical difficulties that we address in this paper. Specifically, we first showcase several characteristics of the age processes modeled through the SHSs tool. Then, we provide a framework to establish the Lagrange stability and positive recurrence of these processes. Building on this, we provide an approach to compute the m-th moment of the age processes. Interestingly, this technique allows us to approximate the average age by solving a simple set of linear equations. Equipped with this approach, we also provide a sequential convex approximation method to optimize the average age by calibrating the parameters of the system. Finally, we consider an age-dependent CSMA environment where the backoff duration depends on the instantaneous age. By leveraging our analysis, we contrast its performance to the age-blind CSMA and showcase the age performance gain provided by the former.
Introducing 2D-FETs in Device Scaling Roadmap using DTCO (2020)

Superior electrostatic control of 2D-FETs enables continued logic power-performance-area (PPA) scaling beyond the 2nm node. Here, we show that WS <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> -based 2D devices give ~40% inverter performance boost against Si at imec 2nm node, using a process-aware DTCO approach. The DTCO is conducted based on an ab-initio calibrated, physical compact model while area scaling is based on contacted gate pitch scaling. Side contacted source/drain, vertically-stacked 2D sheets and fork-sheet architecture are highlighted as key enablers of 2D-FET technology for multiple advanced nodes, using experimentally realistic mobility and Schottky barrier height conditions.
Modeling Actuation Constraints for IoT Applications (2017)

Internet of Things (IoT) promises to bring ease of monitoring, better efficiency and innovative services across many domains with connected devices around us. With information from critical parts of infrastructure and powerful cloud-based data analytics, many applications can be developed to gain insights about IoT systems as well as transform their capabilities. Actuation applications form an essential part of these IoT systems, as they enable automation as well as fast low-level decision making. However, modern IoT systems are designed for data acquisition, and actuation applications are implemented in an ad-hoc manner. We identify modeling constraints in a systematic manner as indispensable to support actuation applications because constraints encompass high-level policies dictated by laws of physics, legal policies, user preferences. We explore data models for constraints inIoT system with the example of a home heating system and illustrate the challenges in enforcing these constraints in theIoT system architecture.
Layered Neural Rendering for Retiming People in Video (2020)

We present a method for retiming people in an ordinary, natural video -- manipulating and editing the time in which different motions of individuals in the video occur. We can temporally align different motions, change the speed of certain actions (speeding up/slowing down, or entirely "freezing" people), or "erase" selected people from the video altogether. We achieve these effects computationally via a dedicated learning-based layered video representation, where each frame in the video is decomposed into separate RGBA layers, representing the appearance of different people in the video. A key property of our model is that it not only disentangles the direct motions of each person in the input video, but also correlates each person automatically with the scene changes they generate -- e.g., shadows, reflections, and motion of loose clothing. The layers can be individually retimed and recombined into a new video, allowing us to achieve realistic, high-quality renderings of retiming effects for real-world videos depicting complex actions and involving multiple individuals, including dancing, trampoline jumping, or group running.
Clinical Effectiveness of New Stent Design: Randomized Single-Blind Comparison of Tail and Double-Pigtail Stents (2000)

In this randomized, single-blind study, the 7F Tail stent produced significantly less irritative symptoms than did the standard 7F double-pigtail stent. Obstructive symptoms tended to be less with the new stent, while flank symptoms were similar.
Optical phase locking of microwave signals and its application to waveform sampling (1991)

Electro-optic sampling technique has potential application in microwave waveform measurement up to the millimeter wave region. However, the time synchronization between microwave signals and laser pulses is very important to reproducing a high quality waveform. Any time jittering between the two signals can cause error in waveform sampling. The synchronization can be established by using a sophisticated frequency synthesizer as the microwave source and synchronizing it with the rf driver of the laser modelocker (another frequency synthesizer).1 However, this type of system is very complex and expensive, especially when applied to the millimeter wave frequency range. Moreover, use of this technique is limited and cannot be applied to measurement of the oscillator waveform on a MMIC.
The gene coding for carbamoyl-phosphate synthetase I was formed by fusion of an ancestral glutaminase gene and a synthetase gene. (1985)

A near full-length cDNA copy of rat carbamoyl-phosphate synthetase I (EC 6.3.4.16) mRNA has been cloned. The cDNA insert in the recombinant plasmid pHN234 is 5.3 kilobases long. Analysis of the sequence coding for carbamoyl-phosphate synthetase I indicates that the gene has arisen from a fusion of two ancestral genes: one homologous to Escherichia coli carA, coding for a glutaminase subunit, and the second homologous to the carB gene that codes for the synthetase subunit. A short amino acid sequence previously proposed to be part of the active site involved in glutamine amide nitrogen transfer in the E. coli and yeast carbamoyl-phosphate synthetases (EC 6.3.5.5) is also present in the rat enzyme. In the mammalian enzyme, however, the glutaminase domain lacks a cysteine residue previously shown to interact with glutamine. The cysteine is replaced by a serine residue. This substitution could, in part, account for the inability of mammalian carbamoyl-phosphate synthetase I to catalyze the hydrolysis of glutamine to glutamic acid and ammonia.
Unified Measure of Goodness and Optimal Design of Spectral (2002)

To evaluate and optimally design spectral sensitivity functions for color input devices, a metric that incorporates practical, significant requirements is desired. The candidate metrics are Vora&#x2013;Trussell's &#x3BC;-factor, a metric based on geometrical difference, and the proposed Unified Measure of Goodness, or UMG, which simultaneously considers the imaging noise and its propagation, colorimetric reproduction accuracy and multi-illuminant color correction. A systematic approach is presented to searching for an optimal set of spectral sensitivity functions from among the complete combinations of the given filter components. Comparative computation results show that &#x3BC;-factor is not a competent metric for the optimal design of camera spectral sensitivity functions while UMG is able to pick out the optimum successfully. Furthermore, the ultimate optimal set has been obtained by selecting the set with highest &#x3BC;-factor value from the sub-optimal collection obtained with UMG. This hierarchical approach comprehensively considers the advantages of both quality metrics. The candidates of the optimal sets based on the given filter components are experimentally tested and presented in the end of the article.
Spectral multiscale coverage with the feature aided CPHD tracker (2014)

A closed loop approach for surveillance was developed leveraging the Spectral Multiscale Coverage (SMC) algorithm for sensor management coupled with the Cardinalized Probability Hypothesis Density (CPHD) multitarget tracker. Additionally, the CPHD was formulated such that it is able to ingest features, if available. Simulations with fixed and mobile sensors (the latter, tasked by the SMC) providing data to the tracker underlined the benefits of sensor fusion with respect to standard metrics of performance.