gebhart/patrepeval huggingface dataset:
Kinetics of Nitric Acid Uptake by Salt (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of Nitric Acid Uptake by SaltFrederick F. Fenter, Francois Caloz, and Michel J. RossiCite this: J. Phys. Chem. 1994, 98, 39, 9801–9810Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/j100090a014https://doi.org/10.1021/j100090a014research-articleACS PublicationsRequest reuse permissionsArticle Views261Altmetric-Citations86LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Applications of compaction testing to the processability of rigid PVC compounds (1981)

Abstract A compaction test has been developed to examine the lubrication and fusion characteristics of PVC compounds. A model of the compaction process at low pressures is proposed which involves two distinct modes of compaction. Initial densification quickly reaches a plateau density, the magnitude of which is determined primarily by frictional properties and the elastic deformability. of the resin particles. A second slower rate densification is attributed to fusion within the PVC resin grains, as well as diffusion between grains. It is shown that compaction alone is insufficient for grain boundary destruction. As a result, significantly higher temperatures are needed to achieve a given state of elasticity development by compaction when compared to material produced by shear processing.
A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets (2017)

We report an automated flow chemistry platform that can efficiently perform a wide range of chemistries, including single/multi-phase and single/multi-step, with a reaction volume of just 14 μL. The breadth of compatible chemistries is successfully demonstrated and the desired products are characterized, isolated, and collected online by preparative HPLC/MS/ELSD.
Species versus Biotype Status (1999)

I was very disappointed to see that the pointless discussion regarding the species versus biotype status of Ara− and Ara+ strains of Burkholderia pseudomalleicontinues (3). My laboratory has performed a number of studies on B. pseudomallei and B. pseudomallei-like strains, and we demonstrated using well-defined criteria that these should be classified as two separate species (1). In 1998, the International Journal of Systematic Bacteriology published a manuscript, based upon peer-reviewed studies from my laboratory, indicating tht B. pseudomallei-like strains should be awarded separate species status and that this species should be named Burkholderia thailandensis (2). The awarding of species status was based upon significant differences between B. thailandensis and B. pseudomallei, including distinctive nucleotide sequence differences in 16S rRNA (15 nucleotide dissimilarities), differences in lipopolysaccharide composition [B. thailandensis synthesizes a repeating disaccharide having the structure →3)-β-d-glucopyranose-(1→3)-6-deoxy-α-l-talopyranose-(1→;B. pseudomallei strains also produce this repeating disaccharide as well as a 1,3-linked homopolymer of 2-O-acetylated 6-deoxy-β-d-manno-heptopyranosyl residues (4, 5)], differences in colonial morphology on Ashdown's selective medium (B. thailandensis colonies are smooth and glossy with a pink pigmentation, while B. pseudomallei colonies are rough and wrinkled with a dark purple pigmentation [6]), biochemical differences (B. thailandensis assimilatesl-arabinose, 5-keto-gluconate, and adonitol, and it does not utilize erythritol and dulcitol as carbon sources; B. pseudomallei does not assimilate l-arabinose, 5-keto-gluconate, and adonitol, and it does utilize erythritol and dulcitol as carbon sources [6]). B. thailandensis is not associated with human disease, and B. pseudomallei is associated with human disease (6),B. thailandensis is avirulent for Syrian golden hamsters (50% lethal dose [LD50] &gt; 105), andB. pseudomallei is virulent for Syrian golden hamsters (LD50 &lt; 100) (2).
Electrical characterization, modeling and reliability analysis of a via last TSV (2010)

In this paper we will report on full wafer electrical characterization based on resistance of various lengths of daisy chain ranging from 10 to 100 TSV's. The resistance of single TSV including metal contact is in range from 5∼20 mOhms. Thermo-mechanical model was developed to investigate the impact of processing and temperature cycling on the mechanical and delamination stresses induced in the structure. The model showed that the thermal and delamination stresses are very much dependent on the conformality of the dielectric layer. For our specific via geometry it is simulated that 75MPa is the minimum adhesion strength required to avoid delamination. After the electrical measurement, the wafers were subjected to thermal cycling from −40 to 125°C for up to 1000 cycles. Wafers were electrically yielding after the 1000 cycles with limited yield loss. The paper reports on the root causes contributing to the decrease in electrical resistance and it was identified that damage to the probing pads is one of the main cause of failure.
Graph-based Classification and Clustering of Entities in Heterogeneous Networks (2009)

We address the problem of multi-label classification of relational graphs by proposing a framework that models the input graph as a first order Markov random field and devises a relaxation labeling procedure to find its maximally likely labeling. We apply this framework to classification as well as clustering problems in homogeneous networks and show significant performance gains in comparison to state-of-the-art techniques.\n \nWe also address the problem of multi-label classification in heterogeneous networks where every data point is associated with a node type and has to be labeled with one or more classes from a type-specific finite set of classes. Our algorithm is based on a random walk model. We present detailed empirical studies of our model and compare it with state-of-art techniques on two social networks.\n\nAll newly proposed algorithms are robust to scarce training data and diverse linkage patterns. They improve classification or clustering quality in homogeneous and heterogeneous networks.
Back Cover: Ethylene to 2‐Butene in a Continuous Gas Phase Reaction using SILP‐Type Cationic Nickel Catalysts (ChemCatChem 1/2014) (2014)

Today's catalytic forecast: migrating front and hot spots The cover picture shows the conversion of ethylene to 1-butene and 2-butene by using a fixed-bed reactor with the catalyst bed consisting of supported ionic liquid phase (SILP) catalyst particles. In their Full Paper on p. 162 ff., P. Wasserscheid et al. describe that the applied homogeneous nickel complex exhibits a high activity and selectivity to 2-butene. The observed catalyst deactivation is attributed to a migrating reaction/deactivation front travelling through the catalyst bed in combination with hot spot formation. The time until catalyst deactivation could be heavily prolonged by optimization of catalytic and process parameters.
Effects of concurrent administration of nevirapine on the disposition of quinine in healthy volunteers (2009)

Abstract Objectives Nevirapine and quinine are likely to be administered concurrently in the treatment of patients with HIV and malaria. Both drugs are metabolised to a significant extent by cytochrome P450 (CYP)3A4 and nevirapine is also an inducer of this enzyme. This study therefore evaluated the effect of nevirapine on the pharmacokinetics of quinine. Methods Quinine (600 mg single dose) was administered either alone or with the 17th dose of nevirapine (200 mg every 12 h for 12 days) to 14 healthy volunteers in a crossover fashion. Blood samples collected at predetermined time intervals were analysed for quinine and its major metabolite, 3-hydroxquinine, using a validated HPLC method. Key findings Administration of quinine plus nevirapine resulted in significant decreases (P &amp;lt; 0.01) in the total area under the concentration–time curve (AUCT), maximum plasma concentration (Cmax) and terminal elimination half-life (T1/2β) of quinine compared with values with quinine dosing alone (AUC: 53.29 ± 4.01 vs 35.48 ± 2.01 h mg/l; Cmax: 2.83 ± 0.16 vs 1.81 ± 0.06 mg/l; T1/2β: 11.35 ± 0.72 vs 8.54 ± 0.76 h), while the oral plasma clearance markedly increased (11.32 ± 0.84 vs 16.97 ± 0.98 l/h). In the presence of nevirapine there was a pronounced increase in the ratio of AUC(metabolite)/AUC (unchanged drug) and highly significant increases in Cmax and AUC of the metabolite (P &amp;lt; 0.01). Conclusions Nevirapine significantly alters the pharmacokinetics of quinine. An increase in the dose of quinine may be necessary when the drug is co-administered with nevirapine.
N‐Type Organic Thermoelectrics: Improved Power Factor by Tailoring Host–Dopant Miscibility (2017)

In this contribution, for the first time, the polarity of fullerene derivatives is tailored to enhance the miscibility between the host and dopant molecules. A fullerene derivative with a hydrophilic triethylene glycol type side chain (PTEG-1) is used as the host and (4-(1,3-dimethyl-2,3-dihydro-1H-benzoimidazol-2-yl)phenyl)dimethylamine n-DMBI) as the dopant. Thereby, the doping efficiency can be greatly improved to around 18% (<1% for a nonpolar reference sample) with optimized electrical conductivity of 2.05 S cm<sup>-1</sup> , which represents the best result for solution-processed fullerene derivatives. An in-depth microstructural study indicates that the PTEG-1 molecules readily form layered structures parallel to the substrate after solution processing. The fullerene cage plane is alternated by the triethylene glycol side chain plane; the n-DMBI dopants are mainly incorporated in the side chain plane without disturbing the π-π packing of PTEG-1. This new microstructure, which is rarely observed for codeposited thin films from solution, formed by PTEG-1 and n-DMBI molecules explains the increased miscibility of the host/dopant system at a nanoscale level and the high electrical conductivity. Finally, a power factor of 16.7 µW m<sup>-1</sup> K<sup>-2</sup> is achieved at 40% dopant concentration. This work introduces a new strategy for improving the conductivity of solution-processed n-type organic thermoelectrics.
Optical interconnects: recent advances and future challenges (2015)

This focus issue is a collection of 17 invited papers showcasing the recent advances and the future challenges of optical interconnect technology. These papers represent multiple key areas that include the enabling devices and components, advances in the system and sub-system technologies as well as networking and its applications.
Effects of biomechanical forces on signaling in the cortical collecting duct (CCD) (2014)

An increase in tubular fluid flow rate (TFF) stimulates Na reabsorption and K secretion in the cortical collecting duct (CCD) and subjects cells therein to biomechanical forces including fluid shear stress (FSS) and circumferential stretch (CS). Intracellular MAPK and extracellular autocrine/paracrine PGE2 signaling regulate cation transport in the CCD and, at least in other systems, are affected by biomechanical forces. We hypothesized that FSS and CS differentially affect MAPK signaling and PGE2 release to modulate cation transport in the CCD. To validate that CS is a physiological force in vivo, we applied the intravital microscopic approach to rodent kidneys in vivo to show that saline or furosemide injection led to a 46.5 ± 2.0 or 170 ± 32% increase, respectively, in distal tubular diameter. Next, murine CCD (mpkCCD) cells were grown on glass or silicone coated with collagen type IV and subjected to 0 or 0.4 dyne/cm(2) of FSS or 10% CS, respectively, forces chosen based on prior biomechanical modeling of ex vivo microperfused CCDs. Cells exposed to FSS expressed an approximately twofold greater abundance of phospho(p)-ERK and p-p38 vs. static cells, while CS did not alter p-p38 and p-ERK expression compared with unstretched controls. FSS induced whereas CS reduced PGE2 release by ∼40%. In conclusion, FSS and CS differentially affect ERK and p38 activation and PGE2 release in a cell culture model of the CD. We speculate that TFF differentially regulates biomechanical signaling and, in turn, cation transport in the CCD.
Enhanced effect of checkpoint inhibitors when given after or together with IMM-101: significant responses in four advanced melanoma patients with no additional major toxicity (2018)

The rapid and complete clinical responses seen in these patients may suggest that IMM-101 is activating a complementary pathway which is synergistic with CPI treatment.
Drug combinations for treatment of mice infected with acyclovir-resistant herpes simplex virus (1987)

The purpose of this study was to determine whether acyclovir resistance in mice infected with herpes simplex virus could be overcome by using high doses of acyclovir or vidarabine alone or by using a combination of the two drugs. The results indicate that the mice infected intracerebrally were refractory to acyclovir alone but responded to vidarabine or a combination of vidarabine and acyclovir. These observations have major implications for the clinical management of severe herpetic infections, particularly if attempts are to be made to devise means of circumventing drug resistance.
Brachydactyly and short stature in a kindred with early‐onset parkinsonism (2004)

In a Dutch kindred we have identified a deletion of the DJ-1 gene, leading to autosomal-recessive parkinsonism. The parkinsonism patients also had short stature and brachydactyly. In the family and a control group from the same community, we used the DJ-1 deletion as a marker for the originally linked PARK7 region and found a significant association with body height (P = 0.005), which suggests a gene in linkage disequilibrium with DJ-1 to be implicated in short stature. Analysis of hand-bone length showed incomplete segregation of the PARK7 region with brachydactyly, such that a gene in PARK7 is unlikely to fully explain the brachydactyly. Since the bone length reduction was more pronounced in the homozygous parkinsonism patients than in their heterozygous relatives, however, the PARK7 region may contain a modifier gene for growth.
IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer (2022)

Immune checkpoint blockade (ICB) has heralded a new era in cancer therapy. Research into the mechanisms underlying response to ICB has predominantly focused on T cells; however, effective immune responses require tightly regulated crosstalk between innate and adaptive immune cells. Here, we combine unbiased analysis of blood and tumors from metastatic breast cancer patients treated with ICB with mechanistic studies in mouse models of breast cancer. We observe an increase in systemic and intratumoral eosinophils in patients and mice responding to ICB treatment. Mechanistically, ICB increased IL-5 production by CD4<sup>+</sup> T cells, stimulating elevated eosinophil production from the bone marrow, leading to systemic eosinophil expansion. Additional induction of IL-33 by ICB-cisplatin combination or recombinant IL-33 promotes intratumoral eosinophil infiltration and eosinophil-dependent CD8<sup>+</sup> T cell activation to enhance ICB response. This work demonstrates the critical role of eosinophils in ICB response and provides proof-of-principle for eosinophil engagement to enhance ICB efficacy.
Computer Vision Based and FPRank Based Tag Recommendation for Social Popularity Enhancement (2018)

In previous work, we have proposed Folk Popularity Rank [4], which can score text tags based on their influence to images' popularity. In this work, we have implemented a tag recommendation system which can assist users in the tagging process. And we have proved that our recommended tags can help users gain higher popularity.
Opposing actions of Fos and Jun on transcription of the phosphoenolpyruvate carboxykinase (GTP) gene. Dominant negative regulation by Fos. (1992)

Jun homodimers and Fos/Jun heterodimers bind to the gene for phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) (PEPCK) at three sites within the first 350 base pairs of the promoter. These include CRE-1 (-82 to -90), and P3(II) and P4 (-252 to -258 and -268 to -285, respectively). Over-expression of Jun in HepG2 cells resulted in a 10-15-fold increase in the level of transcription of a chimeric PEPCK (-490 to +73)-CAT gene, while expression of Fos decreased transcription and blocked the induction of transcription from the PEPCK promoter by Jun. The action of Fos and Jun on PEPCK gene transcription involved each of the Fos/Jun-binding sites and was modulated by additional transcriptional regulatory elements within the PEPCK promoter. The ability of Fos to inhibit PEPCK transcription was dependent upon P3(I), a region of the promoter which does not bind Fos/Jun heterodimers, but does bind members of the C/EBP family of transcription factors. Stimulation of PEPCK transcription by 8-Br-cAMP or by overexpression of the catalytic subunit of protein kinase A was inhibited by Fos expression. The inhibitory effects of phorbol esters and protein kinase C on PEPCK gene expression may be mediated through the action of Fos and Jun.
Tunable topology of photonic systems based on transparent conducting oxides (2018)

Precise control over topology of a photonic system is highly important for a number of applications, such as topologically protected memory/logic devices and quantum communication applications. Within this work, we show that by integrating new transparent conducting oxides (TCOs) material platforms with a photonic waveguide system it is possible to realize ultrafast optical control over topologically nontrivial photonic states.
Polymer Complexes for Electrocatalytic Oxygen Evolution (2022)

Electrocatalytic water oxidation for oxygen gas evolution has been widely studied from the perspective of sustainable technology. However, the use of organic polymers as catalyst layers for this reaction remains un-developed. We discuss, here, the prerequisites, characteristics, and advantages of π-conjugated polymers as electrochemical catalysts to modify anodic current collectors for water oxidation, including some examples by citing the previous works in literature. In section 3, we present our latest results, the use of an organic pol-ymer complex of poly(ethylenedioxythiophene) and phytic acid supported by a hydrophilic poly(hydroxy-ethyl methacrylate) platform, which efficiently generates oxygen gas through anodic water oxidation.
A Preliminary Study on Antimicrobial Edible Films from Pectin and Other Food Hydrocolloids by Extrusion Method (2008)

ABSTRACT Antimicrobial edible films were prepared from natural fiber of pectin and other food hydrocolloids for food packaging or wrapping by extrusion followed by compression or blown film method. Microscopic analysis revealed a well-mixed integrated structure of extruded pellets and an even distribution of the synthetic hydrocolloid in the biopolymers. The resultant composite films possess mechanical properties that are comparable to films cast from most natural hydrocolloids that are consumed as foods or components in processed foods. The inclusion of poly(ethylene oxide) alters the textures of the resultant composite films and therefore demonstrates a new technique for the modification of film properties. The composite films were produced in mild processing conditions, thus the films are able to protect the bioactivity of the incorporated nisin, as shown by the inhibition of Listeria monocytogenes bacterial growth by a liquid incubation method.
Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airways (2021)

Abstract Coronavirus Disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 SARS-CoV-2), which infects host cells with help from the Viral Entry (VE) proteins ACE2, TMPRSS2, and CTSL 1–4 . Proposed risk factors for viral infection, as well as the rate of disease progression, include age 5,6 , sex 7 , chronic obstructive pulmonary disease 7,8 , cancer 9 , and cigarette smoking 10–13 . To investigate whether the proposed risk factors increase viral infection by modulation of the VE genes, we examined gene expression profiles of 796 nasal and 1,673 bronchial samples across four lung cancer screening cohorts containing individuals without COVID-19. Smoking was the only clinical factor reproducibly associated with the expression of any VE gene across cohorts. ACE2 expression was significantly up-regulated with smoking in the bronchus but significantly down-regulated with smoking in the nose. Furthermore, expression of individual VE genes were not correlated between paired nasal and bronchial samples from the same patients. Single-cell RNA-seq of nasal brushings revealed that an ACE2 gene module was detected in a variety of nasal secretory cells with the highest expression in the C15orf48+ secretory cells, while a TMPRSS2 gene module was most highly expressed in nasal keratinizing epithelial cells. In contrast, single-cell RNA-seq of bronchial brushings revealed that ACE2 and TMPRSS2 gene modules were most enriched in MUC5AC+ bronchial goblet cells. The CTSL gene module was highly expressed in immune populations of both nasal and bronchial brushings. Deconvolution of bulk RNA-seq showed that the proportion of MUC5AC+ goblet cells was increased in current smokers in both the nose and bronchus but proportions of nasal keratinizing epithelial cells, C15orf48+ secretory cells, and immune cells were not associated with smoking status. The complex association between VE gene expression and smoking in the nasal and bronchial epithelium revealed by our results may partially explain conflicting reports on the association between smoking and SARS-CoV-2 infection.