gebhart/patrepeval huggingface dataset:
Photocatalytic oxidation of gas-phase BTEX-contaminated waste streams (1995)

Researchers at the National Renewable Energy Laboratory (NREL) have been exploring heterogeneous photocatalytic oxidation (PCO) as a remediation technology for air streams contaminated with benzene, toluene, ethyl-benzene, and xylenes (BTEX). This research is a continuation of work performed on chlorinated organics. The photocatalytic oxidation of BTEX has been studied in the aqueous phase, however, a study by Turchi et al. showed a more economical system would involve stripping organic contaminants from the aqueous phase and treating the resulting gas stream. Another recent study by Turchi et al. indicated that PCO is cost competitive with such remediation technologies as activated carbon adsorption and catalytic incineration for some types of contaminated air streams. In this work we have examined the photocatalytic oxidation of benzene using ozone (0{sub 3}) as an additional oxidant. We varied the residence time in the PCO reactor, the initial concentration of the organic pollutant, and the initial ozone concentration in a single-pass reactor. Because aromatic hydrocarbons represent only a small fraction of the total hydrocarbons present in gasoline and other fuels, we also added octane to the reaction mixture to simulate the composition of air streams produced from soil-vapor-extraction or groundwater-stripping of sites contaminated with gasoline.
Predicting In Vivo Efficacy of Potential Restenosis Therapies by Cell Culture Studies: Species-Dependent Susceptibility of Vascular Smooth Muscle Cells (2008)

Although drug-eluting stents (DES) are successfully utilized for restenosis therapy, the development of local and systemic therapeutic means including nanoparticles (NP) continues. Lack of correlation between in vitro and in vivo studies is one of the major drawbacks in developing new drug delivery systems. The present study was designed to examine the applicability of the arterial explant outgrowth model, and of smooth muscle cells (SMC) cultures for prescreening of possible drugs. Elucidation of different species sensitivity (rat, rabbit, porcine and human) to diverse drugs (tyrphostins, heparin and bisphsophonates) and a delivery system (nanoparticles) could provide a valuable screening tool for further in vivo studies. The anticipated sensitivity ranking from the explant outgrowth model and SMC mitotic rates (porcine>rat>>rabbit>human) do not correlate with the observed relative sensitivity of those animals to antiproliferative therapy in restenosis models (rat>/=rabbit>porcine>human). Similarly, the inhibitory profile of the various antirestenotic drugs in SMC cultures (rabbit>porcine>rat>>human) do not correlate with animal studies, the rabbit- and porcine-derived SMC being highly sensitive. The validity of in vitro culture studies for the screening of controlled release delivery systems such as nanoparticles is limited. It is suggested that prescreening studies of possible drug candidates for restenosis therapy should include both SMC cell cultures of rat and human, appropriately designed with a suitable serum.
Automatic Integration of Facade Textures into 3D Building Models with a Projective Geometry Based Line Clustering (2002)

Visualization of city scenes is important for many applications including entertainment and urban mission planning. Models covering wide areas can be efficiently constructed from aerial images. However, only roof details are visible from aerial views; ground views are needed to provide details of the building facades for high quality 'fly-through' visualization or simulation applications. We present an automatic method of integrating facade textures from ground view images into 3D building models for urban site modeling. We first segment the input image into building facade regions using a hybrid feature extraction method, which combines global feature extraction with Hough transform on an adaptively tessellated Gaussian Sphere and local region segmentation. We estimate the external camera parameters by using the corner points of the extracted facade regions to integrate the facade textures into the 3D building models. We validate our approach with a set of experiments on some urban sites. Categories and Subject Descriptors (according to ACM CCS): I.3.3 [Computer Graphics]: Modeling packages
Human CD18 Is the Functional Receptor forAggregatibacter actinomycetemcomitansLeukotoxin (2007)

Aggregatibacter (Actinobacillus) actinomycetemcomitans is the causative organism of localized aggressive periodontitis, a rapidly progressing degenerative disease of the gingival and periodontal ligaments, and is also implicated in causing subacute infective endocarditis in humans. The bacterium produces a variety of virulence factors, including an exotoxic leukotoxin (LtxA) that is a member of the repeats-in-toxin (RTX) family of bacterial cytolysins. LtxA exhibits a unique specificity to macrophages and polymorphonuclear cells of humans and other primates. Human lymphocyte function-associated antigen 1 (LFA-1) has been implicated as the putative receptor for LtxA. Human LFA-1 comprises the CD11a and CD18 subunits. It is not clear, however, which of its subunits serves as the functional receptor that confers species-specific susceptibility to LtxA. Here we demonstrate that the human CD18 is the receptor for LtxA based on experiments performed with chimeric beta2-integrins recombinantly expressed in a cell line that is resistant to LtxA effects. In addition, we show that the cysteine-rich tandem repeats encompassing integrin-epidermal growth factor-like domains 2, 3, and 4 of the extracellular region of human CD18 are critical for conferring susceptibility to LtxA-induced biological effects.
Sulcal Depth-Position Profile Is a Genetically Mediated Neuroscientific Trait: Description and Characterization in the Central Sulcus (2013)

Genetic and environmental influences on brain morphology were assessed in an extended-pedigree design by extracting depth-position profiles (DPP) of the central sulcus (CS). T1-weighted magnetic resonance images were used to measure CS length and depth in 467 human subjects from 35 extended families. Three primary forms of DPPs were observed. The most prevalent form, present in 70% of subjects, was bimodal, with peaks near hand and mouth regions. Trimodal and unimodal configurations accounted for 15 and 8%, respectively. Genetic control accounted for 56 and 66% of between-subject variance in average CS depth and length, respectively, and was not significantly influenced by environmental factors. Genetic control over CS depth ranged from 1 to 50% across the DPP. Areas of peak heritability occurred at locations corresponding to hand and mouth areas. Left and right analogous CS depth measurements were strongly pleiotropic. Shared genetic influence lessened as the distance between depth measurements was increased. We argue that DPPs are powerful phenotypes that should inform genetic influence of more complex brain regions and contribute to gene discovery efforts.
Radio resource management across multiple protocol layers in satellite networks: a tutorial overview (2005)

Abstract Satellite transmissions have an important role in telephone communications, television broadcasting, computer communications, maritime navigation, and military command and control. Moreover, in many situations they may be the only possible communication set‐up. Trends in telecommunications indicate that four major growth market/service areas are messaging and navigation services (wireless and satellite), mobility services (wireless and satellite), video delivery services (cable and satellite), and interactive multimedia services (fibre/cable, satellite). When using geostationary satellites (GEO), the long propagation delay may have great impact, given the end‐to‐end delay user's requirements of relevant applications; moreover, atmospheric conditions may seriously affect data transmission. Since satellite bandwidth is a relatively scarce resource compared to the terrestrial one (e.g. in optical transport networks), and the environment is harsher, resource management of the radio segment plays an important role in the system's efficiency and economy. The radio resource management (RMM) entity is responsible for the utilization of the air interface resources, and covers power control, handover, admission control, congestion control, bandwidth allocation, and packet scheduling. RRM functions are crucial for the best possible utilization of the capacity. RRM functions can be implemented in different ways, thus having an impact on the overall system efficiency. This tutorial aims to provide an overview of satellite transmission aspects at various OSI layers, with emphasis on the MAC layer; some cross‐layer solutions for bandwidth allocation are also indicated. Far from being an exhaustive survey (mainly due to the extensive nature of the subject), it offers the readers an extensive bibliography, which could be used for further research on specific aspects. Copyright © 2005 John Wiley &amp; Sons, Ltd.
Anthracycline metabolites from baumycin-producing Streptomyces sp. D788. III. New anthracycline metabolites produced by blocked mutants 4L-660 and YDK-18. (1993)

In a previous paper,1} we described isolation of a variety of blocked mutants from baumycinproducing Streptomyces sp. D788 and identification of the biosynthetically blocked anthracycline metabolites produced by some of them. This paper deals with details of the anthracyclines produced by another two blocked mutants, strains 4L-660 and YDK-18. To well define the blocked mutants, all detectable anthracycline products accumulated in their culture broths were isolated, identified and quantified for their yields. Both the two mutants were found to produce only two anthracycline metabolites without any yield of their parental daunorubicin or 1 1-deoxydaunorubicin. Mutant 4L-660 produced a new metabolite, D788-5 (7-0daunosaminyl-4-O-methyl-e-rhodomycinone), and
The reversible P2Y12antagonist ACT‐246475 causes significantly less blood loss than ticagrelor at equivalent antithrombotic efficacy in rat (2017)

The P2Y<sub>12</sub> receptor is a validated target for prevention of major adverse cardiovascular events in patients with acute coronary syndrome. The aim of this study was to compare two direct-acting, reversible P2Y<sub>12</sub> antagonists, ACT-246475 and ticagrelor, in a rat thrombosis model by simultaneous quantification of their antithrombotic efficacy and surgery-induced blood loss. Blood flow velocity was assessed in the carotid artery after FeCl<sub>3</sub> -induced thrombus formation using a Doppler flow probe. At the same time, blood loss after surgical wounding of the spleen was quantified. Continuous infusions of ACT-246475 and ticagrelor prevented the injury-induced reduction of blood flow in a dose-dependent manner. High doses of both antagonists normalized blood flow and completely abolished thrombus formation as confirmed by histology. Intermediate doses restored baseline blood flow to ≥65%. However, ACT-246475 caused significantly less increase of blood loss than ticagrelor; the difference in blood loss was 2.6-fold (P < 0.01) at high doses and 2.7-fold (P < 0.05) at intermediate doses. Potential reasons for this unexpected difference were explored by measuring the effects of ACT-246475 and ticagrelor on vascular tone. At concentrations needed to achieve maximal antithrombotic efficacy, ticagrelor compared with ACT-246475 significantly increased carotid blood flow velocity in vivo (P = 0.003), induced vasorelaxation of precontracted rat femoral arteries, and inhibited contraction of femoral artery induced by electrical field stimulation or by phenylephrine. Overall, ACT-246475 showed a significantly wider therapeutic window than ticagrelor. The absence of vasodilatory effects due to high selectivity of ACT-246475 for P2Y<sub>12</sub> provides potential arguments for the observed safety advantage of ACT-246475 over ticagrelor.
Platelets subvert T cell immunity against cancer via GARP-TGFβ axis (2017)

Cancer-associated thrombocytosis has long been linked to poor clinical outcome, but the underlying mechanism is enigmatic. We hypothesized that platelets promote malignancy and resistance to therapy by dampening host immunity. We show that genetic targeting of platelets enhances adoptive T cell therapy of cancer. An unbiased biochemical and structural biology approach established transforming growth factor β (TGFβ) and lactate as major platelet-derived soluble factors to obliterate CD4<sup>+</sup> and CD8<sup>+</sup> T cell functions. Moreover, we found that platelets are the dominant source of functional TGFβ systemically as well as in the tumor microenvironment through constitutive expression of the TGFβ-docking receptor glycoprotein A repetitions predominant (GARP) rather than secretion of TGFβ per se. Platelet-specific deletion of the GARP-encoding gene <i>Lrrc32</i> blunted TGFβ activity at the tumor site and potentiated protective immunity against both melanoma and colon cancer. Last, this study shows that T cell therapy of cancer can be substantially improved by concurrent treatment with readily available antiplatelet agents. We conclude that platelets constrain T cell immunity through a GARP-TGFβ axis and suggest a combination of immunotherapy and platelet inhibitors as a therapeutic strategy against cancer.
1P2-N06 Grasp Posture Determination for Industrial Robot by Potential Method (2015)

In Japan, the labor power is decreasing by the aging population and lower birthrate. In production fields, there is a big demand for robots to compensate for reduced manpower. To introduce them lead to such advantages as more efficient production, high quality and improvement of working conditions. Various robots have already worked in the factories. However, the functions performed by them are limited and difficult to adapt to different environments because most factory robots are only controlled by sequence control. To solve this problem, We used the pneumatic robot arm driven by pneumatic actuators. The pneumatic robot arm has 2 DOF and grasps an object from various directions because it is like a human hand. These advantages could relieve constraint condition for the posture of robot hand tip part. Therefore, We proposed grasp posture determination method that material handling system was divide into industrial robot and pneumatic robot arm. We used potential method to decide all joints angles of my system by desire position. We determined each joint angle of industrial robot and pneumatic robot arm in stages. Finally, by performing the specified task, We could verify my determined grasp posture and the validity of proposed grasp posture determination method.
Real‐time scheduling of multiple uncertain receding horizon control systems (2008)

Abstract In this paper, a new scheduling approach is proposed that considers the effect of modeling uncertainty for multiple continuous time receding horizon control (RHC) systems. This is accomplished by combining a scheduling approach with results from the continuous time nonlinear systems theory. It is shown that using a rate monotonic priority assignment method combined with analytical bounds on the prediction error, the problem of scheduling multiple uncertain plants can be cast into an appropriate constrained optimization problem. The constraints guarantee that the processes will be schedulable. The optimization provides optimized performance and balanced resource allocation in the presence of uncertainty. The proposed method was applied to a real‐time simulation of RHC trajectory tracking for two hovercraft vehicles demonstrating the validity of the approach. Copyright © 2008 John Wiley &amp; Sons, Ltd.
High temperature 4H-silicon carbide thyristors and power MOSFETs (1996)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation John W. Palmour, Scott T. Allen, Ranbir Singh, Lori A. Lipkin, Douglas G. Waltz; High temperature 4H‐silicon carbide thyristors and power MOSFETs. AIP Conf. Proc. 1 March 1996; 361 (1): 1321–1326. https://doi.org/10.1063/1.49902 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Multi-dimensional Graph Convolutional Networks (2018)

Convolutional neural networks (CNNs) leverage the great power in representation learning on regular grid data such as image and video. Recently, increasing attention has been paid on generalizing CNNs to graph or network data which is highly irregular. Some focus on graph-level representation learning while others aim to learn node-level representations. These methods have been shown to boost the performance of many graph-level tasks such as graph classification and node-level tasks such as node classification. Most of these methods have been designed for single-dimensional graphs where a pair of nodes can only be connected by one type of relation. However, many real-world graphs have multiple types of relations and they can be naturally modeled as multi-dimensional graphs with each type of relation as a dimension. Multi-dimensional graphs bring about richer interactions between dimensions, which poses tremendous challenges to the graph convolutional neural networks designed for single-dimensional graphs. In this paper, we study the problem of graph convolutional networks for multi-dimensional graphs and propose a multi-dimensional convolutional neural network model mGCN aiming to capture rich information in learning node-level representations for multi-dimensional graphs. Comprehensive experiments on real-world multi-dimensional graphs demonstrate the effectiveness of the proposed framework.
Mechanical circulatory support in patients with severe aortic stenosis and left ventricular dysfunction undergoing percutaneous coronary intervention (2017)

Management of obstructive coronary artery disease in patients with aortic stenosis and severe left ventricular dysfunction is challenging. Mechanical circulatory support at the time of percutaneous coronary interventions may be necessary in these extreme-risk patients. We present a case in which the TandemHeart was used to support a patient with severe aortic stenosis, severe protected left main and circumflex disease, and severe cardiomyopathy and review the literature on this subject.
Lithium Thiophosphate Glasses and Glass–Ceramics as Solid Electrolytes: Processing, Microstructure, and Properties (2013)

Lithium solid electrolytes are of major interest for solid‐state batteries and electrochemical capacitors (ECs). Currently, the material selection space of liquid electrolytes is dominated by lithium salts paired with organics. Improved safety, as well as the need for higher temperature and high voltage operation, opens up opportunities for glass and ceramic alternatives in these important solid‐state energy storage technologies. Lithium thiophosphates in the family x Li 2 S + (1−x) P 2 S 5 (mol fraction) possess room temperature ionic conductivities greater than 10 −3 (Ω‐cm) ‐1 in crystallized x = 0.70 (almost the highest in inorganic solid‐state electrolytes). Within this review article, we address recent progress made in this class of material. We consider the role of densification on the Li‐ion conductivity, as well as our recent data on the effect of densification on the electrochemical properties of the system. We cover the processing techniques of mechanical milling and pressure‐forming, discuss microstructure, bulk versus surface conduction, and device integration. The systematic improvement in ionic conductivity with increased density suggests that bulk conduction dominates surface conduction and demonstrates that dense, rather than porous, lithium thiophosphate solid electrolytes are important in the design of solid‐state batteries and ECs.
SUN-038 Role Of The Satb 1 Gene In Growth Across Species: Findings In A Cohort Of Patients With Short Stature And In A Knockout Zebrafish Model (2019)

Background: Short stature is a common pediatric disorder, affecting 3% of the population; however, the identification of its cause is limited by its largely variable clinical presentation and genetic heterogeneity. Identification of novel genetic causes of short stature is of great importance to customize the therapeutic approach of this entity. The especial AT-rich sequence binding protein1 gene (SATB1) encodes a chromatin organizer with important roles in cell growth and immunosuppression. SATB1 is highly expressed in the pituitary gland, where it regulates the differentiation of PIT1 positive cells. Indeed, the conditional knockout of Satb1 in the mouse pituitary decreases growth hormone expression, leading to reduced growth. Aim: To investigate the putative role of SATB1 in growth in a cohort of individuals with short stature and in a zebrafish knockout (KO) model. Methods: We obtained germline DNA samples from a cohort of 287 Brazilian patients diagnosed with short stature (height <2 SDS for age and sex), including 52 patients small for gestational age (SGA), 5 cases with growth hormone deficiency (GHD), 10 cases with syndromic short stature and 220 cases with idiopathic short stature. All cases were screened for SATB1 copy number variations (CNVs) using droplet digital PCR, and 190 cases were screened for mutations via Sanger sequencing. In silico predictions were retrieved from the Varsome browser. All variants were annotated to RefSeq NM_002971.5. Using CRISPR-Cas9, we generated two lines of zebrafish satb1 bearing frameshift mutations; both lines were crossed to obtain full KOs. Growth was monitored from 3 to 12 weeks post-fertilization (wpf) and expression of pituitary hormones was analyzed at 6 wpf by quantitative PCR. Results: No variants predicted as damaging were found in the short stature cohort. Nevertheless, variants of uncertain significance (VUS, mostly intronic) were found in 11% of our cohort, in which 57% of the individuals that carry a VUS presented familial short stature while 43% were non-familial. Interestingly, the variant c.515+112G>A was identified in 3/33 (9.1%) of SGA patients, but only in 2/143 (1.4%) of ISS patients. No CNVs were observed. In the zebrafish model, satb1 knockout led to significantly smaller size at 3 wpf, compared with heterozygous and wild type controls (median standard length: 6.6, 7.4, and 7.8 cm, and mean weight: 2.7, 4.3, and 4.6 mg, respectively, P<0.05 for all comparisons). At 6 wpf, we identified a trend for lower gh1 expression in the KOs vs. heterozygous zebrafish (relative quantification: 0.68 vs. 1.79, P=0.06). Conclusion: Our results support a role for SATB1 in regulating growth hormone production across species. Although loss of SATB1 function could theoretically lead to growth hormone deficiency in humans, defects in this gene do not seem to play a crucial role in the height of individuals with short stature.