gebhart/patrepeval huggingface dataset:
Technique for total knee arthroplasty using simultaneous cementing of components (1991)

The surgical technique for total knee arthroplasty (TKA) as performed by the senior author is reviewed. Certain steps in the procedure are discussed in detail to provide insight into how these steps can be carried out more precisely with reproducible results. The method of cementing all three components with one mixture of cement is particularly helpful and time saving, which makes cemented fixation more attractive. As in any surgery, attention to detail and organization produces superior results.
SmartObjects (2018)

The emergence of smart objects has the potential to radically change the way we interact with technology. Through embedded means for input and output, such objects allow for more natural and immediate interaction.
(Digital Presentation) Characterization of Ultrafast Dynamics of Refractory Metal Nanoparticles of Interest as Photocatalysts (2022)

Plasmonic noble metal nanoparticles are of interest as photocatalysts for several reasons, including a very large absorption cross section and the creation of a greatly enhanced evanescent electromagnetic field at the surface of the nanoparticles when excited at the plasmon resonance. Furthermore, the plasmon resonance is tunable over a wide wavelength range as a function of the size, shape, and composition of the nanoparticles. When these properties are combined with the known photocatalytic activity of noble metals for technologically important targets such as solar fuels, it is not surprising that these nanoparticle systems are widely studied. Noble metals do, however, possess a weakness in that they can be easily melted upon photoexcitation, due to the fact that noble metals dissipate absorbed photon energy efficiently through ultrafast electron-phonon coupling, in roughly one picosecond, to produce heat. As a result, the study of new classes of plasmonic materials, such as refractory metals, with much higher melting points than noble metals is growing rapidly. While there are still challenges in the size-selective synthesis of refractory metal nanoparticles, characterization efforts on these materials are of strong interest. We report here a study on the time-resolved spectroscopy of electron-phonon coupling in refractory metal nanoparticles. There are very significant variations in the efficiency and time-scales of electron-phonon coupling in refractory metal nanoparticles as compared to noble metal nanoparticles. Furthermore, due to the fact that many refractory metals are oxidized under ambient conditions to create a thin oxide layer on the surface of the nanoparticles, these materials also demonstrate dynamics related to electron injection from the metal to the oxide layer that noble metals do not show. Far from being a negative, the added electron injection dynamics offer new opportunities for photocatalysis that we discuss. Use of the Center for Nanoscale Materials, an Office of Science user facility, was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357.
Wavelength Selective Coupler with Vertical Gratings on Silicon Chip (2007)

We demonstrate a wavelength selective coupler on a silicon chip using vertical grating structures, which possess simplicity in design and fabrication. The coupler can be used for add- drop filters and other functional devices.
Epimerase and Reductase Activities of Polyketide Synthase Ketoreductase Domains Utilize the Same Conserved Tyrosine and Serine Residues (2016)

The role of the conserved active site tyrosine and serine residues in epimerization catalyzed by polyketide synthase ketoreductase (PKS KR) domains has been investigated. Both mutant and wild-type forms of epimerase-active KR domains, including the intrinsically redox-inactive EryKR3° and PicKR3° as well as redox-inactive mutants of EryKR1, were incubated with [2-(2)H]-(2R,3S)-2-methyl-3-hydroxypentanoyl-SACP ([2-(2)H]-2) and 0.05 equiv of NADP(+) in the presence of the redox-active, epimerase-inactive EryKR6 domain. The residual epimerase activity of each mutant was determined by tandem equilibrium isotope exchange, in which the first-order, time-dependent washout of isotope from 2 was monitored by liquid chromatography-tandem mass spectrometry with quantitation of the deuterium content of the diagnostic pantetheinate ejection fragment (4). Replacement of the active site Tyr or Ser residues, alone or together, significantly reduced the observed epimerase activity of each KR domain with minimal effect on substrate binding. Our results demonstrate that the epimerase and reductase activities of PKS KR domains share a common active site, with both reactions utilizing the same pair of Tyr and Ser residues.
Methods to Evaluate Changes in Mitochondrial Structure and Function in Cancer (2023)

Mitochondria are regulators of key cellular processes, including energy production and redox homeostasis. Mitochondrial dysfunction is associated with various human diseases, including cancer. Importantly, both structural and functional changes can alter mitochondrial function. Morphologic and quantifiable changes in mitochondria can affect their function and contribute to disease. Structural mitochondrial changes include alterations in cristae morphology, mitochondrial DNA integrity and quantity, and dynamics, such as fission and fusion. Functional parameters related to mitochondrial biology include the production of reactive oxygen species, bioenergetic capacity, calcium retention, and membrane potential. Although these parameters can occur independently of one another, changes in mitochondrial structure and function are often interrelated. Thus, evaluating changes in both mitochondrial structure and function is crucial to understanding the molecular events involved in disease onset and progression. This review focuses on the relationship between alterations in mitochondrial structure and function and cancer, with a particular emphasis on gynecologic malignancies. Selecting methods with tractable parameters may be critical to identifying and targeting mitochondria-related therapeutic options. Methods to measure changes in mitochondrial structure and function, with the associated benefits and limitations, are summarized.
Double-coupled systems for roadway IPT systems (2014)

Dynamic powering of in-motion Electric Vehicles (EV) using Inductive Power Transfer (IPT) can potentially solve many of the problems currently faced by EVs: in particular range, cost and charging rate. However there is currently limited research focused on suitable IPT primary supply-side infrastructure for such roadway IPT systems, and most proposed systems so far have limitations which affect their usefulness and/or suitability. This paper presents a new roadway IPT system called the “double-coupled system” (DCS) which can resolve these limitations. The proposed system introduces an “intermediary coupler” (IC) circuit between the power supply primary track and each ground transmitter pad/coil arrangement. Individual power sections on the roadway can be controlled independently using the intermediary couplers and only turned on when required, and as such minimize unwanted magnetic leakage fields. The proposed system is highly reliable and fault tolerant, allows high power transfer at high frequency, and is also efficient and cost effective. It can also reduce the impact of dynamic EV charging on the electrical grid at the times of traffic congestion. A laboratory scale prototype system has been constructed and tested. The intermediary coupler achieved an efficiency of 85% at an output power of 5kW with full system operability.
Inhibition of poly(ADP-ribose) glycohydrolase activity by cyclic peptide antibiotics containing piperazic acid residues (2002)

A member of the cyclic hexadepsipeptide family, PD124,966, isolated from a fermentation product of an actinomycete, inhibited poly(ADP-ribose) glycohydrolase (Parg) with IC50 of 40 pg/ml. A novel cyclic peptide, pargamicin, isolated from a fermentation broth of Amicolatopsis sp., also inhibited Parg with IC50 of 28 pg/ml. A linear peptide containing piperazic acid residues, piperastatin A, isolated from Streptomyces lavendofoliae, did not inhibit Parg activity.
MEMS characterization with conformal imaging vibrometry (CIV) (2014)

This paper discusses a new conformal imaging fiber-optic heterodyne vibrometer developed for in-vacuum measurement of MEMS micro-resonator spatial dynamics in real time. The all-fiber optic probe design incorporates many standard fiber-optic telecommunications components, configured to enable light delivery directly to the MEMS device under test in vacuum. The CIV measures the equatorial dynamics of micro-shells currently being developed as microscale hemispherical resonant gyroscopes (HRG). The modular fiber optic design lends itself readily to other conformal configurations (e.g planar, multi-faceted) or to simultaneous measurement of shell, stem and substrate dynamics.
Patterning of substrates using surface relief structures on azobenzene functionalized polymers (2003)

The facile, all optical, single-step fabrication of surface relief structures (SRS) on azobenzene functionalized polymers has been investigated extensively due to the their potential use in a wide range of applications such as holographic image storage, polarization discrimination, waveguide couplers and fabrication of phase masks &amp; intricate surface structures (1). The photo-induced reversible trans-cis-trans isomerization of the azobenzene groups in the polymer causes the formation of SRS at a temperature substantially below the glass transition temperature. This photo-fabrication technique has been used for inscription of intricate patterns (micron to sub micron features) on polymeric films. The use of such SRS for mask-free patterning of surfaces is presented.
4 - Phase closure in optical astronomy (1985)

On envisage des simplifications aux techniques récemment proposées afin d'utiliser la « fermeture de phase » en&#13;\nastronomie optique, techniques visant à obtenir la limite théorique de diffraction en imagerie .&#13;\nLa méthode envisagée permet de corriger des images isolées, obtenues à courte exposition et dégradées par la&#13;\nturbulence atmosphérique, jusqu'à la limite de diffraction malgré la traversée de l'atmosphère terrestre . Elle prend&#13;\ntoute son importance lorsqu'on l'applique à obtenir des images de haute résolution à partir d'une orbite autour de la&#13;\nTerre sans qu'il soit nécessaire de disposer à bord du satellite d'une surface de haute précision optique sur une&#13;\ngrande ouverture .&#13;\nA la base de cette méthode : un interféromètre à pupilles multiples, comportant suffisament de redondances internes&#13;\npour pouvoir séparer les paramètres de l'objet de ceux de l'instrument, chacun étant déterminé alors sans introduire&#13;\nde modèles a priori .&#13;\nPour une application spatiale, le champ pourrait être dédoublé au moyen de séparateurs et de retards optiques&#13;\nautorisant des mesures à large bande. Une source de référence permet alors dans l'un des champs la stabilisation&#13;\nactive de l'instrument - une précision de 1/100 de longueur d'onde paraît accessible, en étudiant une configuration&#13;\npraticable, sur une étoile de magnitude inférieure a 12 . L'autre champ est alors disponible pour de longues&#13;\nintégrations sur des objects faibles .
The Renormalization Group and Its Applications to Generating Coarse-Grained Models of Large Biological Molecular Systems (2017)

Understanding the dynamics of biomolecules is the key to understanding their biological activities. Computational methods ranging from all-atom molecular dynamics simulations to coarse-grained normal-mode analyses based on simplified elastic networks provide a general framework to studying these dynamics. Despite recent successes in studying very large systems with up to a 100,000,000 atoms, those methods are currently limited to studying small- to medium-sized molecular systems due to computational limitations. One solution to circumvent these limitations is to reduce the size of the system under study. In this paper, we argue that coarse-graining, the standard approach to such size reduction, must define a hierarchy of models of decreasing sizes that are consistent with each other, i.e., that each model contains the information of the dynamics of its predecessor. We propose a new method, Decimate, for generating such a hierarchy within the context of elastic networks for normal-mode analysis. This method is based on the concept of the renormalization group developed in statistical physics. We highlight the details of its implementation, with a special focus on its scalability to large systems of up to millions of atoms. We illustrate its application on two large systems, the capsid of a virus and the ribosome translation complex. We show that highly decimated representations of those systems, containing down to 1% of their original number of atoms, still capture qualitatively and quantitatively their dynamics. Decimate is available as an OpenSource resource.
Effects of ECG Signal Processing on the Inverse Problem of Electrocardiography (2018)

The inverse problem of electrocardiography is ill-posed. Errors in the model such as signal noise can impact the accuracy of reconstructed cardiac electrical activity. It is currently not known how sensitive the inverse problem is to signal processing techniques. To evaluate this, experimental data from a Langendorff-perfused pig heart (n=1) suspended in a human-shaped torso-tank was used. Different signal processing methods were applied to torso potentials recorded from 128 electrodes embedded in the tank surface. Processing methods were divided into three categories i) high-frequency noise removal ii) baseline drift removal and iii) signal averaging, culminating in n=72 different signal sets. For each signal set, the inverse problem was solved and reconstructed signals were compared to those directly recorded by the sock around the heart. ECG signal processing methods had a dramatic effect on reconstruction accuracy. In particular, removal of baseline drift significantly impacts the magnitude of reconstructed electrograms, while the presence of high-frequency noise impacts the activation time derived from these signals (p<0.05).
Paper‐Based, Capacitive Touch Pads (2012)

Metallized paper is patterned to create touch pads of arrayed buttons that are sensitive to contact with both bare and gloved fingers. The paper-based keypad detects the change in capacitance associated with the touch of a finger to one of its buttons. Mounted on an alarmed cardboard box, the keypad requires the appropriate sequence of touches to disarm the system.
Optical Waveguides by Germanium Ion Implantation on Silicon-on-Insulator Platform (2018)

We demonstrated a new type of integrated photonic waveguides formed by Ge ion implantation in the silicon slab on silicon-on-insulator platform. They were successfully fabricated and characterised, and can be potentially erased by laser annealing.
Human pancreatic enzymes. Isolation and properties of a major form of chymotrypsin (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHuman pancreatic enzymes. Isolation and properties of a major form of chymotrypsinJames Travis, Michael H. Coan, and Ronald C. RobertsCite this: Biochemistry 1971, 10, 14, 2711–2717Publication Date (Print):July 1, 1971Publication History Published online1 May 2002Published inissue 1 July 1971https://pubs.acs.org/doi/10.1021/bi00790a009https://doi.org/10.1021/bi00790a009research-articleACS PublicationsRequest reuse permissionsArticle Views197Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Quantum Walks in Periodic and Quasiperiodic Fibonacci Fibers (2020)

Quantum walk is a key operation in quantum computing, simulation, communication and information. Here, we report for the first time the demonstration of quantum walks and localized quantum walks in a new type of optical fibers having a ring of cores constructed with both periodic and quasiperiodic Fibonacci sequences, respectively. Good agreement between theoretical and experimental results has been achieved. The new multicore ring fibers provide a new platform for experiments of quantum effects in low-loss optical fibers which is critical for scalability of real applications with large-size problems. Furthermore, our new quasiperiodic Fibonacci multicore ring fibers provide a new class of quasiperiodic photonics lattices possessing both on- and off-diagonal deterministic disorders for realizing localized quantum walks deterministically. The proposed Fibonacci fibers are simple and straightforward to fabricate and have a rich set of properties that are of potential use for quantum applications. Our simulation and experimental results show that, in contrast with randomly disordered structures, localized quantum walks in new proposed quasiperiodic photonics lattices are highly controllable due to the deterministic disordered nature of quasiperiodic systems.
Development of a Compact CO2 Instrument for Small Aerial Platforms (2019)

High accuracy CO2 instrumentation for airborne platforms would bridge the gap between land and satellite measurements. Here we present ongoing work on a novel temperature and pressure compensated sensor for measuring dry-air corrected CO2 concentrations.
Spektrale Photon-Counting Computertomografie: Anwendung für die virtuelle Koloskopie ohne Abführen (2017)

Es soll das klinische Potential der spektralen Photon-Counting Computertomografie (SPCCT) für die virtuelle Koloskopie mit elektronischem Abführen des iodmarkierten Stuhls untersucht werden, wobei die charakteristische K-Kante von Gadolinium zur Unterscheidbarkeit zwischen den Kontrastmitteln Iod (oral) und Gadolinium (intravenös) einbezogen wird.
Non-Invasive Respiration Rate Estimation Using Ultra-Wideband Distributed Cognitive Radar System (2006)

It has been shown that remote monitoring of pulmonary activity can be achieved using ultra-wideband (UWB) systems, which shows promise in home healthcare, rescue, and security applications. In this paper, a geometry-based statistical channel model is developed for simulating the reception of UWB signals in the indoor propagation environment. This model enables replication of time-varying multipath profiles due to the displacement of a human chest. Subsequently, a UWB distributed cognitive radar system (UWB-DCRS) is developed for the robust detection of chest cavity motion and the accurate estimation of respiration rate. The analytical framework can serve as a basis in the planning and evaluation of future measurement programs
Studies of dijet transverse momentum balance and pseudorapidity distributions in pPb collisions at $$\sqrt{s_{\mathrm{NN}}} = 5.02$$ s NN = 5.02 $$\,\text {TeV}$$ TeV (2014)

Dijet production has been measured in pPb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV. A data sample corresponding to an integrated luminosity of 35 nb -1 was collected using the Compact Muon Solenoid detector at the Large Hadron Collider. The dijet transverse momentum balance, azimuthal angle correlations, and pseudorapidity distributions are studied as a function of the transverse energy in the forward calorimeters (E 4<||<5.2 T
In vitro comparison of burst tension and puncture pressure in commonly used organ retrieval bags (2004)

Eichel, Louis MD∗; Abdelshehid, Corollos BS∗; Lee, David I MD∗; Uribe, Carlos MD∗; McDougall, Elspeth M MD∗; Clayman, Ralph V MD, FACS∗,*,1 Author Information
The Application of Hybrid Video Theodolite for Dynamic Analysis of Human Gait Motion. (2001)

Generally, Human motion analysis has been performed under the condition that the camera position and the rotation are fixed. Furthermore, the human motion analysis is performed within the limited space. However, in order to analyze the most natural human motion, limitations for camera and space should be removed.For this ideal condition, some problems should be resolved. These problems include camera parameters while tracking, real-time imaging, auto tracking moving object, 3D data acquisition, and synchronization of video image sequences and camera rotation parameters while tracking.With this objective and for multiple applications such as 3D objects modeling and so on, Hybrid Video Theodolite (HVT) system was developed by the authors.The applications of the HVT system for dynamic analysis of human gait motion are investigated in this paper.
Removal of the Pyridine Directing Group from α-Substituted N-(Pyridin-2-yl)piperidines Obtained via Directed Ru-Catalyzed sp3 C–H Functionalization (2013)

Two strategies, "hydrogenation-hydride reduction" and "quaternization-hydride reduction", are reported that make use of mild reaction conditions (room temperature) to efficiently remove the N-pyridin-2-yl directing group from a diverse set of C-2-substituted piperidines that were synthesized through directed Ru-catalyzed sp(3) C-H functionalization. The deprotected products are obtained in moderate to good overall yields irrespective of the strategy followed, indicating that both methods are generally equally effective. Only in the case of 2,6-disubstituted piperidines, could the "quaternization-hydride reduction" strategy not be used. The "hydrogenation-hydride reduction" protocol was successfully applied to trans- and cis-2-methyl-N-(pyridin-2-yl)-6-undecylpiperidine in a short synthetic route toward (±)-solenopsin A (trans diastereoisomer) and (±)-isosolenopsin A (cis diastereoisomer). The absolute configuration of the enantiomers of these fire ant alkaloids could be determined via VCD spectroscopy.
Functional Hydrogel Surfaces: Binding Kinesin‐Based Molecular Motor Proteins to Selected Patterned Sites (2005)

Abstract Hydrogel microstructures with micrometer‐scale topography and controllable functionality have great potential for numerous nanobiotechnology applications including, for example, three‐dimensional structures that exhibit controlled interactions with proteins and cells. Taking advantage of the strong affinity of histidine (His) residues for metal‐ion–nitrilotriacetic acid (NTA) complexes, we have chemically modified hydrogels to enable protein immobilization with retention of activity by incorporating 2‐methacrylamidobutyl nitrilotriacetic acid, an NTA‐containing monomer that can be copolymerized with a series of monomers to form NTA‐containing hydrogels. By varying the NTA‐monomer composition in the hydrogels, it is possible to control the amount of protein bound to the hydrogel surface. The retention of biological activity was demonstrated by microtubule gliding assays. Normally, hydrogels are resistant to protein binding, but we have selected these materials because of their porous nature. Bringing together hydrogel functionalization and soft‐lithography patterning techniques, it was possible to create a hybrid hydrogel superstructure that possesses binding specificity to His‐tagged protein in selected sites. This type of surface and microstructure is not only advantageous for motor protein integration, but it can also be generally applied to the formation of His‐tagged molecules for sensors and biochip applications.