gebhart/patrepeval huggingface dataset:
Polymyxin and Bacitracin in the Irrigation Solution Provide No Benefit for Bacterial Killing in Vitro (2019)

These data suggest that the addition of polymyxin-bacitracin to saline solution irrigation has little value. Given the cost and antimicrobial resistance implications, our findings, combined with prior clinical literature, provide adequate reason to avoid widespread use of antibiotics in irrigation solutions. Povidone-iodine may be a more effective and safer option.
Dynamically Actuated Liquid‐Infused Poroelastic Film with Precise Control over Droplet Dynamics (2018)

Abstract Traditional dynamic adaptive materials rely on an atomic/molecular mechanism of phase transition to induce macroscopic switch of properties, but only a small number of these materials and a limited responsive repertoire are available. Here, liquid as the adaptive component is utilized to realize responsive functions. Paired with a porous matrix that can be put in motion by an actuated dielectric elastomer film, the uncontrolled global flow of liquid is broken down to well‐defined reconfigurable localized flow within the pores and conforms to the network deformation. A detailed theoretical and experimental study of such a dynamically actuated liquid‐infused poroelastic film is discussed. This system demonstrates its ability to generate tunable surface wettability that can precisely control droplet dynamics from complete pinning, to fast sliding, and even more complex motions such as droplet oscillation, jetting, and mixing. This system also allows for repeated and seamless switch among these different droplet manipulations. These are desired properties in many applications such as reflective display, lab‐on‐a‐chip, optical device, dynamic measurements, energy harvesting, and others.
Novel Small-Molecule Hybrid-Antibacterial Agents against S. aureus and MRSA Strains (2021)

Ongoing resistance developments against antibiotics that also affect last-resort antibiotics require novel antibacterial compounds. Strategies to discover such novel structures have been dimerization or hybridization of known antibacterial agents. We found novel antibacterial agents by dimerization of indols and hybridization with carbazoles. They were obtained in a simple one-pot reaction as bisindole tetrahydrocarbazoles. Further oxidation led to bisindole carbazoles with varied substitutions of both the indole and the carbazole scaffold. Both the tetrahydrocarbazoles and the carbazoles have been evaluated in various <i>S. aureus</i> strains, including MRSA strains. Those 5-cyano substituted derivatives showed best activities as determined by MIC values. The tetrahydrocarbazoles partly exceed the activity of the carbazole compounds and thus the activity of the used standard antibiotics. Thus, promising lead compounds could be identified for further studies.
The impact of information sharing on installation processes of offshore wind farms - process modelling and simulation-based analysis (2020)

The installation of offshore wind energy turbines is accompanied by great challenges arising from the dynamic environment, which influences logistics processes. Communication plays a major role for cost-efficient installation processes, due to the coordination needed between different partners involved in the offshore wind energy supply chain. A detailed process analysis revealed the importance of shared information about weather conditions, storage capacities and vessel availabilities. By applying a simulation study, which evaluates eight information sharing scenarios, the influence of the following execution time-related performance measures is investigated: average time in manufacturer storage, average time in port, total installation time and average vessel usage time. As a result, the simulation study verifies that sharing information between supply chain partners can contribute to more efficient logistics processes. However, the achievable prediction accuracy and the interdependencies between the information items have a major influence on the quality of results.
Selective Formation of Heteroligated Pt(II) Complexes with Bidentate Phosphine-Thioether (P,S) and Phosphine-Selenoether (P,Se) Ligands via the Halide-Induced Ligand Rearrangement Reaction (2010)

Bidentate phosphine-selenoether (P,Se) ligands were synthesized, and their heteroligated Pt(II) complexes were made and studied. The unique "P,S/P,Se" ligand coordination to Pt(II) can be realized via the halide-induced ligand rearrangement reaction. In all cases, the exclusive formation of semi-open heteroligated complexes was achieved as shown by (31)P and (77)Se NMR spectroscopy and from single crystal X-ray diffraction studies. This is the first example of the use of (77)Se NMR spectroscopy to characterize these types of structures through direct observation of the weak-link interaction with the metal center. Heteroligated structure formation is believed to be driven by the relative electron-donating ability of the substituent groups on the seleno or thioether moieties. This effect is studied by comparing the structures of corresponding "P,SMe" and "P,SeMe" complexes bearing a hemilabile "P,SCH(2)CF(3)" group, which is less sterically demanding than "P,SPh" but is similar in terms of electron withdrawing ability.
The WD40 Domain Protein MSI1 Functions in a Histone Deacetylase Complex to Fine-Tune Abscisic Acid Signaling (2015)

MSI1 belongs to a family of histone binding WD40-repeat proteins. Arabidopsis thaliana contains five genes encoding MSI1-like proteins, but their functions in diverse chromatin-associated complexes are poorly understood. Here, we show that MSI1 is part of a histone deacetylase complex. We copurified HISTONE DEACETYLASE19 (HDA19) with MSI1 and transcriptional regulatory SIN3-like proteins and provide evidence that MSI1 and HDA19 associate into the same complex in vivo. These data suggest that MSI1, HDA19, and HISTONE DEACETYLATION COMPLEX1 protein form a core complex that can integrate various SIN3-like proteins. We found that reduction of MSI1 or HDA19 causes upregulation of abscisic acid (ABA) receptor genes and hypersensitivity of ABA-responsive genes. The MSI1-HDA19 complex fine-tunes ABA signaling by binding to the chromatin of ABA receptor genes and by maintaining low levels of acetylation of histone H3 at lysine 9, thereby affecting the expression levels of ABA receptor genes. Reduced MSI1 or HDA19 levels led to increased tolerance to salt stress corresponding to the increased ABA sensitivity of gene expression. Together, our results reveal the presence of an MSI1-HDA19 complex that fine-tunes ABA signaling in Arabidopsis.
Universal Current Scaling in the Critical Region of a Two-Dimensional Superconducting Phase Transition (1979)

The transition to a superconducting state in ultrathin (\ensuremath{\sim}30 \AA{}) granular niobium nitride is found to obey scaling laws characteristic of critical regions near phase transitions. Dynamic scaling of voltage with current is theoretically suggested in analogy with magnetic phase transitions and is experimentally demonstrated. A universal function of current and temperature involving two independent critical exponents is generated.
Low cost eye surgery simulator with skill assessment component. (2007)

Ophthalmic surgeons require years of training and continuous practice to successfully manipulate the delicate tissues of the human eye. Development of the fine motor skills is a crucial component of this training. Virtual eye surgery simulators have come on the market in recent years leveraging the advantages of virtual procedures. However adoption is limited by the high initial investment and availability of models. Our approach consists of a low cost hybrid approach that employs a standard porcine model for cataract training and a platform that is instrumented to record interaction forces and video. In a preliminary study we have recorded procedure data for a small number of experts which shows good signal-to-noise ratio suitable for development of objective skill assessment models.
AiEEG: Personalized Seizure Prediction Through Partially-Reconfigurable Deep Neural Networks (2022)

With more than 65M people affected by epilepsy worldwide, early prediction and response to seizure onsets have become more important than ever. Cutting-edge research in implantable medical devices (IMDs) has shown that deep neural networks (DNNs) applied to intracranial electroencephalogram (iEEG) data can predict seizures up to an hour before onset. However, offloading of iEEG data to the edge/cloud is highly prohibitive, due to the sheer size of the generated data. Existing work either focuses on the DNN training phase only, or does not consider the severe energy/space limitations of IMDs. Moreover, the technical aspects of patient personalization, which allows for patient-specific hyper-parameter tuning, still remain unaddressed. In this paper, we propose a platform called AiEEG for in vivo early seizure prediction, whose DNN hardware circuitry can be reconfigured remotely without surgery. We prototype AiEEG on a system on chip (SoC) platform and demonstrate its end-to-end capabilities in seizure prediction with a population of 30 epileptic patients, with iEEG signals coming from a real-world dataset. Extensive experimental results shows that (i) our embedded and personalized DNN has an area under the curve (AUC) averaging at 0.97 and as low as zero false positives per hour (FPH) for over half the patients, an improvement of about 3.5x with respect to a non-personalized prediction method and the best for a dataset of this size when compared to the state-of-the-art; (ii) our AiEEG platform consumes 4.2x less energy than a cloud-based approach, leading to a 4x battery lifetime improvement; (iii) we are able to remotely fine-tune the DNN through partial reconfiguration as needed in about 10s.
Neuroendocrine Tumors (2010)

More education regarding the treatment of NETs, including pertinent studies, is needed for physicians. Additional multicenter, prospective, placebo-controlled trials are necessary to demonstrate the benefits of somatostatin analogs, including their ability to control symptoms and affect tumor growth, and their synergistic effect with other therapies. New trials should be reported consistently and include time to tumor progression and progression-free survival as primary or secondary end points.
Frequency response measurement of half-wave voltage and chirp parameter of LiNbO<inf>3</inf> intensity modulators in low frequency range (2011)

We measured frequency responses of half-wave voltage V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">π</sub> and chirp parameter α <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> of LiNbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> modulators below 1 GHz range using optical heterodyne scheme with an acousto-optic modulator. The coefficients of variation of the measured values of V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">π</sub> and α <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> are 0.2 % and 2 %, respectively. We observed strong dependency of V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">π</sub> and α <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> on the frequency.
A new heuristics for finding the delay constrained least cost path (2004)

We investigate the problem of finding the delay constrained least cost path (DCLC) in a network, which is NP-complete and has been extensively studied. Many proposed algorithms tackle this problem by transforming it into the shortest path selection problem or the k-shortest paths selection problem, which are NP-complete, with an integrated weight function that maps the delay and cost for each link into a single weight. However, they suffer from either high computational complexity or low success ratio in finding the optimal paths (the least cost path satisfying a given delay constraint). Based on the extended Bellman-Ford (EB) algorithm, we propose a high performance algorithm, dual extended Bellman-Ford (DEB) algorithm, which achieves a high success ratio in finding the least cost path subject to a delay constraint with low computational complexity. Extensive simulations show that DEB outperforms its contender on: the worst-case computational complexity; average cost of the solutions; the success ratio in finding the delay constrained least cost path.
Release behavior and toxicity profiles towards A549 cell lines of ciprofloxacin from its layered zinc hydroxide intercalation compound (2013)

Strong host-guest interactions between the LZH lattice and the CFX anion give rise to a new intercalation compound that demonstrates sustained release mode and enhanced toxicity effects towards A549 cell lines. These findings should serve as foundations towards further developments of the brucite-like host material in drug delivery systems.
Venting (2022)

No AccessInjection Mold Design EngineeringOct 2022VentingDavid O. KazmerDavid O. KazmerSearch for more papers by this authorhttps://doi.org/10.3139/9781569908921.008SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2022Pages: 269-289Print ISBN: 978-1-56990-891-4eISBN: 978-1-56990-892-1 Copyright & Permissions© 2022 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Control of the electrical and adhesion properties of metal/organic interfaces with self-assembled monolayers (2005)

With the aim of improving the electrical and adhesion properties of a noble-metal electrode (Ag)/organic interface, a SH-terminated self-assembled monolayer (SAM) that reacts with the silver atoms of the electrode was tested. Silver atoms deposited on the SH-modified surface were found to bind strongly to the terminal sulfur atoms as a result of the reaction between sulfur and silver. In contrast, silver atoms deposited onto a CH3-modified surface do not react with the SAM. The specific contact resistance of the interface between the SH-terminated surface and the silver electrode (1.31×10−2Ωcm2) was found to be much lower than that of the silver thin film deposited on the CH3-modified surface (495.58Ωcm2).
Enzymatic depletion of l‐Met using an engineered human enzyme as a novel therapeutic strategy for melanoma (2023)

Many cancers, including melanoma, have a higher requirement for l-methionine in comparison with noncancerous cells. In this study, we show that administration of an engineered human methionine-γ-lyase (hMGL) significantly reduced the survival of both human and mouse melanoma cells in vitro. A multiomics approach was utilized to identify global changes in gene expression and in metabolite levels with hMGL treatment in melanoma cells. There was considerable overlap in the perturbed pathways identified in the two data sets. Common pathways were flagged for further investigation to understand their mechanistic importance. In this regard, hMGL treatment induced S and G2 phase cell cycle arrest, decreased nucleotide levels, and increased DNA double-strand breaks suggesting an important role for replication stress in the mechanism of hMGL effects on melanoma cells. Further, hMGL treatment resulted in increased cellular reactive oxygen species levels and increased apoptosis as well as uncharged transfer RNA pathway upregulation. Finally, treatment with hMGL significantly inhibited the growth of both mouse and human melanoma cells in orthotopic tumor models in vivo. Overall, the results of this study provide a strong rationale for further mechanistic evaluation and clinical development of hMGL for the treatment of melanoma skin cancer and other cancers.
Synthetic extracellular matrices and astrocytes provide a supportive microenvironment for the cultivation and investigation of primary pediatric gliomas (2022)

Our sECM culture platform provides a multipurpose tool for pediatric brain tumor researchers that enables both a wide breadth of biological assays and the cultivation of diverse tumor types.
Correction: The effect of molecular aggregation of thermally activated delayed fluorescence sensitizers for hyperfluorescence in organic light-emitting diodes (2022)

Correction for ‘The effect of molecular aggregation of thermally activated delayed fluorescence sensitizers for hyperfluorescence in organic light-emitting diodes’ by Eun Young Park et al. , J. Mater. Chem. C , 2022, 10 , 4705–4716, DOI: https://doi.org/10.1039/D1TC04712D.
Advanced Composite Materials in Flexural Members for Auto-adaptive Structural Response Modification (2002)

Peer Reviewed
Selective through-holing of anodic porous alumina membranes with large area (2018)

Anodic porous alumina membranes with site controlled through-holes were prepared by the formation of a masking layer on the surface of anodic porous alumina and subsequent selective second anodization in concentrated sulfuric acid to form a readily soluble layer. After the anodization, the residual Al substrate was removed, and the highly soluble alumina layer formed in concentrated sulfuric acid was dissolved selectively by wet etching. An advantageous point of this process is the controllability of the pattern of through-holes, and the preparation of large samples with selective through-holes is possible. The pattern of through-holes was controlled by changing the mask pattern formed on the surface of anodic porous alumina. The alumina membranes obtained by this process are expected to be used for various applications that require porous alumina membranes with site controlled through-holes.
The Limits of Linked Suppression for Regulatory T Cells (2016)

The limits of linkage appear to be quantitative and not universally determined by either the indirect pathway or by peptides of donor MHC Ags.
Food responsiveness regulates episodic behavioral states inCaenorhabditis elegans (2017)

Animals optimize survival and reproduction in part through control of behavioral states, which depend on an organism's internal and external environments. In the nematode <i>Caenorhabditis elegans</i> a variety of behavioral states have been described, including roaming, dwelling, quiescence, and episodic swimming. These states have been considered in isolation under varied experimental conditions, making it difficult to establish a unified picture of how they are regulated. Using long-term imaging, we examined <i>C. elegans</i> episodic behavioral states under varied mechanical and nutritional environments. We found that animals alternate between high-activity (active) and low-activity (sedentary) episodes in any mechanical environment, while the incidence of episodes and their behavioral composition depend on food levels. During active episodes, worms primarily roam, as characterized by continuous whole body movement. During sedentary episodes, animals exhibit dwelling (slower movements confined to the anterior half of the body) and quiescence (a complete lack of movement). Roaming, dwelling, and quiescent states are manifest not only through locomotory characteristics but also in pharyngeal pumping (feeding) and in egg-laying behaviors. Next, we analyzed the genetic basis of behavioral states. We found that modulation of behavioral states depends on neuropeptides and insulin-like signaling in the nervous system. Sensory neurons and the Foraging homolog EGL-4 regulate behavior through control of active/sedentary episodes. Optogenetic stimulation of dopaminergic and serotonergic neurons induced dwelling, implicating dopamine as a dwell-promoting neurotransmitter. Our findings provide a more unified description of behavioral states and suggest that perception of nutrition is a conserved mechanism for regulating animal behavior.<b>NEW & NOTEWORTHY</b> One strategy by which animals adapt to their internal states and external environments is by adopting behavioral states. The roundworm <i>Caenorhabditis elegans</i> is an attractive model for investigating how behavioral states are genetically and neuronally controlled. Here we describe the hierarchical organization of behavioral states characterized by locomotory activity, feeding, and egg-laying. We show that decisions to engage in these behaviors are controlled by the nervous system through insulin-like signaling and the perception of food.
A reciprocity approach for determining radiation patterns of patch antennas on circularly-cylindrical platforms (2002)

There has been rapidly growing interest in conformal patch antennas that can be mounted on arbitrarily curved surfaces. One of the major factors influencing the popularity of these antennas is their potentially useful application in mobile communication systems. This has also fueled a need for more powerful and versatile computational modeling techniques for this class of antennas. We present an efficient method, based on the reciprocity theorem, for calculating the radiation patterns of patch antennas mounted on circularly cylindrical platforms when the current distribution on the patches is available from previous computations. The major advantages of this approach are that it does not require the evaluation of complicated layered media Green's functions for curved geometrics and circumvents the need to calculate time consuming Sommerfeld integrals. The technique also has the highly desirable feature that it is easily generalizable to patch antennas of arbitrary shape.
First Results of the SRF Wafer Test Cavity for the Characterization of Superconductors (2014)

The wafer test cavity was designed as a short sample test system that could create a reproducible environment for the testing of superconducting materials above the Bardeen-Cooper- Schrieffer limit of niobium. The results of the sapphire test cavity showed that the dielectric was too lossy, and thus, the original design had to be altered to make operation feasible with current hardware and achieve ~200 mT. The new design was fabricated at Thomas Jefferson National Accelerator Facility and was cryogenically tested. After four tests, the cavity was able to produce a 6.6-mT field with a Q of 3.96 * 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8</sup> . Although lower than anticipated, in comparison to other TE01 cavities, this result is quite encouraging. Multipacting and coupling were limitations, but current work is pursuing the elimination of these complications. This document will expound upon the new design, mathematical simulations, testing of the cavity, complications, results, and future work.
CD4 + T Cells and the Proinflammatory Cytokines Gamma Interferon and Interleukin-6 Contribute to Alveolar Bone Loss in Mice (1999)

In this study, we used a mouse model to examine the role of the adaptive immune response in alveolar bone loss induced by oral infection with the human gram-negative anaerobic bacterium Porphyromonas gingivalis. Severe combined immunodeficient mice, which lack B and T lymphocytes, exhibited considerably less bone loss than did immunocompetent mice after oral infection, suggesting that lymphocytes contribute to this process. Bone loss after oral infection was decreased in mice deficient in major histocompatibility complex (MHC) class II-responsive CD4(+) T cells, but no change in bone loss was observed in mice deficient in MHC class I-responsive CD8(+) T cells or NK1(+) T cells. Mice lacking the cytokine gamma interferon or interleukin-6 also demonstrated decreased bone loss. These results suggest that the adaptive immune response, and in particular CD4(+) T cells and the proinflammatory cytokines that they secrete, are important effectors of bone loss consequent to P. gingivalis oral infection. The studies also reinforce the utility of the mouse oral infection model in dissecting the pathobiology of periodontal disease.