gebhart/patrepeval huggingface dataset:
Negative modulation of suppressive HIV-specific regulatory T cells by IL-2 adjuvanted therapeutic vaccine (2017)

The potential benefit in using IL-2 in immunotherapy for cancer and autoimmunity has been linked to the modulation of immune responses, which partly relies on a direct effect on Tregs populations. Here, we revisited the role of IL-2 in HIV infection and investigated whether its use as an adjuvant with therapeutic vaccination, impacts on HIV-specific responses. Antiretroviral therapy treated-patients were randomized to receive 4 boosts of vaccination (ALVACHIV/Lipo-6T, weeks 0/4/8/12) followed by 3 cycles of IL-2 (weeks 16/24/32) before treatment interruption (TI) at week40. IL-2 administration increased significantly HIV-specific CD4+CD25+CD134+ T-cell responses, which inversely correlated with viral load after TI (r = -0.7, p <0.007) in the vaccine/IL-2 group. IL-2 increased global CD25+CD127lowFoxP3+Tregs (p <0.05) while it decreased HIV- but not CMV- specific CD39+FoxP3+CD25+CD134+Tregs (p <0.05). HIV-specific Tregs were inversely correlated with IFN-γ producing specific-effectors (p = 0.03) and positively correlated with viral load (r = 0.7, p = 0.01), revealing their undesired presence during chronic infection. Global Tregs, but not HIV-specific Tregs, inversely correlated with a decrease in exhausted PD1+CD95+ T-cells (p = 0.001). Altogether, our results underline the negative impact of HIV-specific Tregs on HIV-specific effectors and reveal the beneficial use of IL-2 as an adjuvant as its administration increases global Tregs that impact on T-cell exhaustion and decreases HIV-specific CD39+Tregs by shifting the balance towards effectors.
A timescale-guided microfluidic synthesis of tannic acid-FeIII network nanocapsules of hydrophobic drugs (2023)

Many drugs are poorly water-soluble and suffer from low bioavailability. Metal-phenolic network (MPN), a hydrophilic thin layer such as tannic acid (TA)-Fe<sup>III</sup> network, has been recently used to encapsulate hydrophobic drugs to improve their bioavailability. However, it remains challenging to synthesize nanocapsules of a wide variety of hydrophobic drugs and to scale up the production in a continuous manner. Here, we present a microfluidic synthesis method to continuously produce TA-Fe<sup>III</sup> network nanocapsules of hydrophobic drugs. We hypothesize that nanocapsules can continuously be formed only when the microfluidic mixing timescale is shorter than the drug's nucleation timescale. The hypothesis was tested on three hydrophobic drugs - paclitaxel, curcumin, and vitamin D with varying solubility and nucleation timescale. The proposed mechanism was validated by successfully predicting the synthesis outcomes. The microfluidically-synthesized nanocapsules had well-controlled sizes of 100-200 nm, high drug loadings of 40-70%, and a throughput of up to 70 mg hr<sup>-1</sup> per channel. The release kinetics, cellular uptake, and cytotoxicity were further evaluated. The effect of coating constituents on nanocapsule properties were characterized. Fe content of nanocapsules was reported. The stability of nanocapsules at different temperatures and pHs were also tested. The results suggest that the present method can provide a quantitative guideline to predictively design a continuous synthesis scheme for hydrophobic drug encapsulation via MPN nanocapsules with scaled-up capability.
Thermal modeling of Direct Bonded Heterogenous Integration (DBHi) MCM package with Si microcooler (2022)

with the rapid advancement of high-density packaging technology, heterogeneous integration of multi-chip module (MCM) has emerged as a viable solution to achieve increasing demands for electronic device performance. Placing the multiple dies in close proximity enables high bandwidth, low latency, and low power consumption of the system. However, thermal management of such high-performance electronic device has become critical challenge associated with ever increasing power dissipation. Insufficient heat removal and large temperature gradient over the chip will seriously affect the reliability degradation. Previous study has demonstrated stacked silicon microcooler with single-phase liquid cooling as one of the effective solutions to address such thermal challenges. The thermal performance of the silicon microcooler was measured to be ~ 32 mm2K/W at a flow rate of 25 mL/s while using single heat source with power of 600 W.This paper expands the prior work to MCM with four functional chips integrated in a single package and evaluated the cooling capability of silicon microcooler with new designs. Novel designs of stacked silicon microcooler subjected to MCM - namely inlet-centered flow cross-flow, counter-flow, and rotational-flow were developed and numerically analyzed using Computational Fluid Dynamics (CFD) simulation. Heat transfer performance and fluid flow behavior of these types of microcoolers were investigated and compared to the conventional microcooler with straight channel structure. In this work, two cases of heat source conditions were studied, (Case-A) four chips having identical power density, and (Case-B) four chips having different power density. Simulation result indicated that for Case-A, inlet-centered microcooler showed the best heat dissipation performance in terms of the maximum temperature rise and temperature uniformity of the chip. It also achieved the lowest pressure drop among the others. For Case-B, microcooler design which contains various flow directions, such as cross-flow or rotational-flow had superior thermal performance to the conventional microcooler.
Ex vivoemission of volatile organic compounds from gastric cancer and non-cancerous tissue (2018)

The presence of certain volatile organic compounds (VOCs) in the breath of patients with gastric cancer has been reported by a number of research groups; however, the source of these compounds remains controversial. Comparison of VOCs emitted from gastric cancer tissue to those emitted from non-cancerous tissue would help in understanding which of the VOCs are associated with gastric cancer and provide a deeper knowledge on their generation. Gas chromatography with mass spectrometric detection (GC-MS) coupled with head-space needle trap extraction (HS-NTE) as the pre-concentration technique, was used to identify and quantify VOCs released by gastric cancer and non-cancerous tissue samples collected from 41 patients during surgery. Excluding contaminants, a total of 32 VOCs were liberated by the tissue samples. The emission of four of them (carbon disulfide, pyridine, 3-methyl-2-butanone and 2-pentanone) was significantly higher from cancer tissue, whereas three compounds (isoprene, γ-butyrolactone and dimethyl sulfide) were in greater concentration from the non-cancerous tissues (Wilcoxon signed-rank test, p < 0.05). Furthermore, the levels of three VOCs (2-methyl-1-propene, 2-propenenitrile and pyrrole) were correlated with the occurrence of H. pylori; and four compounds (acetonitrile, pyridine, toluene and 3-methylpyridine) were associated with tobacco smoking. Ex vivo analysis of VOCs emitted by human tissue samples provides a unique opportunity to identify chemical patterns associated with a cancerous state and can be considered as a complementary source of information on volatile biomarkers found in breath, blood or urine.
ChemInform Abstract: A Direct, Versatile Route to Functionalized Trialkoxysilanes. (2014)

Abstract The peroxide initiated radical addition of dithiocarbonates (I) and (VII) to trialkoxy vinylsilanes (II) leads to functionalized trialkoxysilanes (III) and (VIII), respectively.
445: Over-Expression of Heat Shock Protein 27 Confers Resistance Androgen Ablation and Chemotherapy in Prostate Cancer Lncap Xenografts (2005)

You have accessJournal of UrologyModerated Poster, Sunday, May 22, 2005, 1:00 - 3:00 pm1 Apr 2005445: Over-Expression of Heat Shock Protein 27 Confers Resistance Androgen Ablation and Chemotherapy in Prostate Cancer Lncap Xenografts Palma Rocchi, Eliana Beraldi, Susan Ettinger, and Martin E. Gleave Palma RocchiPalma Rocchi More articles by this author , Eliana BeraldiEliana Beraldi More articles by this author , Susan EttingerSusan Ettinger More articles by this author , and Martin E. GleaveMartin E. Gleave More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)34698-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "445: Over-Expression of Heat Shock Protein 27 Confers Resistance Androgen Ablation and Chemotherapy in Prostate Cancer Lncap Xenografts." The Journal of Urology, 173(4S), pp. 121–122 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 121-122 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Palma Rocchi More articles by this author Eliana Beraldi More articles by this author Susan Ettinger More articles by this author Martin E. Gleave More articles by this author Expand All Advertisement PDF DownloadLoading ...
Classification of Occupancy Sensor Anomalies in Connected Indoor Lighting Systems (2019)

We consider the problem of classifying anomalous occupancy sensor behavior in connected indoor lighting systems. Anomalous occupancy sensor behavior may occur in the form of either a high number of false alarms (type-1 anomalies) or missed detections (type-2 anomalies). Two anomaly discovery scenarios are considered: one, in which no anomalies exist post-deployment, and two, in which both anomaly types are found together with normally functional sensors. We address the problem of classifying anomalies that may occur subsequently using a machine learning approach. Under scenario 1, we consider a one class random forest classifier to determine whether an occupancy signal is normal or not. In scenario 2, we consider a supervised random forest classifier to determine whether the detection signal of an occupancy sensor is normal, or exhibits type-1 or type-2 anomalies. We devise occupancy signal features in time and frequency domains to perform 2-class classification in scenario 1, and 3-class classification in scenario 2. The proposed method is evaluated using motion sensor data from an office building, and is shown to have higher true positive rate and a lower false positive rate in comparison to an unsupervised k -means method and a random forest classifier with a single signal energy feature.
BurstLink: Techniques for Energy-Efficient Conventional and Virtual\n Reality Video Display (2021)

Conventional planar video streaming is the most popular application in mobile\nsystems and the rapid growth of 360 video content and virtual reality (VR)\ndevices are accelerating the adoption of VR video streaming. Unfortunately,\nvideo streaming consumes significant system energy due to the high power\nconsumption of the system components (e.g., DRAM, display interfaces, and\ndisplay panel) involved in this process.\n We propose BurstLink, a novel system-level technique that improves the energy\nefficiency of planar and VR video streaming. BurstLink is based on two key\nideas. First, BurstLink directly transfers a decoded video frame from the host\nsystem to the display panel, bypassing the host DRAM. To this end, we extend\nthe display panel with a double remote frame buffer (DRFB), instead of the\nDRAM's double frame buffer, so that the system can directly update the DRFB\nwith a new frame while updating the panel's pixels with the current frame\nstored in the DRFB. Second, BurstLink transfers a complete decoded frame to the\ndisplay panel in a single burst, using the maximum bandwidth of modern display\ninterfaces. Unlike conventional systems where the frame transfer rate is\nlimited by the pixel-update throughput of the display panel, BurstLink can\nalways take full advantage of the high bandwidth of modern display interfaces\nby decoupling the frame transfer from the pixel update as enabled by the DRFB.\nThis direct and burst frame transfer of BurstLink significantly reduces energy\nconsumption in video display by reducing access to the host DRAM and increasing\nthe system's residency at idle power states.\n We evaluate BurstLink using an analytical power model that we rigorously\nvalidate on a real modern mobile system. Our evaluation shows that BurstLink\nreduces system energy consumption for 4K planar and VR video streaming by 41%\nand 33%, respectively.\n
Calcium Channel Diversity and Neurotransmitter Release: The Omega-Conotoxins and Omega-Agatoxins (1994)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
Notice of Removal: High efficiency wireless power transfer for EV charging and other applications (2017)

Removed.
Solution‐Deposited Zinc Oxide and Zinc Oxide/Pentacene Bilayer Transistors: High Mobility n‐Channel, Ambipolar, and Nonvolatile Devices (2008)

Abstract A solution processed n‐channel zinc oxide (ZnO) field effect transistor (FET) was fabricated by simple dip coating and subsequent heat treatment of a zinc acetate film. The field effect mobility of electrons depends on ZnO grain size, controlled by changing the number of coatings and zinc acetate solution concentration. The highest electron mobility achieved by this method is 7.2 cm 2 V −1 s −1 with On/Off ratio of 70. This electron mobility is higher than for the most recently reported solution processed ZnO transistor. We also fabricated bilayer transistors where the first layer is ZnO, and the second layer is pentacene, a p‐channel organic which is deposited by thermal evaporation. By changing the ZnO grain size (or thickness) this type of bilayer transistor shows p‐channel, ambipolar and n‐channel behavior. For the ambipolar transistor, well balanced electron and hole mobilities are 7.6 × 10 −3 and 6.3 × 10 −3 cm 2 V −1 s −1 respectively. When the ZnO layer is very thin, the transistor shows p‐channel behavior with very high reversible hysteresis. The nonvolatile tuning function of this transistor was investigated.
Conformations of Silicon-Containing Rings. 5., Conformational Properties of 1-Methyl-1-silacyclohexane:  Gas Electron Diffraction, Low-Temperature NMR, and Quantum Chemical Calculations (2002)

The molecular structure of 1-methyl-1-silacyclohexane 3 has been determined by gas electron diffraction (GED). The conformational preference of the methyl group was studied experimentally in the gas phase (GED) and in solution (low-temperature (13)C NMR) and by quantum chemical calculations (HF, MP2, and B3LYP with 6-31G basis sets and mPW1PW91/6-311G(2df,p)). Both experimental methods result in a preference of the equatorial position of the methyl group, 68(7)% in the gas phase at 298 K and 74(1)% in solution at 110 K. The calculations predict 68-73% equatorial conformer at room temperature. From coalescence temperatures, Gibbs free energies of activation for ring inversion DeltaG++ (eq --> ax) = 5.81(18) and DeltaG++ (ax --> eq) = 5.56(18) kcal mol(-1) were derived. The calculated values for DeltaG++ (eq --> ax) are 5.92 (B3LYP) and 5.84 kcal mol(-1) (mPW1PW91).
Editorial. COVID-19 and spinal surgery (2020)

Author(s): Ghogawala, Zoher; Kurpad, Shekar; Falavigna, Asdrubal; Groff, Michael W; Sciubba, Daniel M; Wu, Jau-Ching; Park, Paul; Berven, Sigurd; Hoh, Daniel J; Bisson, Erica F; Steinmetz, Michael P; Wang, Marjorie C; Chou, Dean; Sansur, Charles A; Smith, Justin S; Tumialán, Luis M
Supplementary figures from <i>In Vitro</i> Priming of Adoptively Transferred T Cells with a RORγ Agonist Confers Durable Memory and Stemness <i>In Vivo</i> (2023)

&lt;p&gt;Supplementary Figure S1 shows that RORgamma agonist treatment does not impact the transduction efficiency of CAR virus. Supplementary Figure S2 shows that RORgamma agonist treatment increases IL-17A secretion from TRP-1 Th0 and Th17 cells. Included in Supplementary Figure S3 are spaghetti plots showing data of individual mice used in main Figure 3 and survival curves of TRP-1 Th17 transferred mice. Supplementary Figure S4 presents bar graphs of memory markers. Graphs in Supplementary Figure S5 showing eradication of primary tumors by Type 17 T cells and the frequency of donor cells after third tumor challenge supplement the data described in Figure 7. Supplementary Figure S6 shows that after adoptive cell transfer, RORgamma agonist primed donor T cells contain fewer Treg cells and express lower levels of PD-1.&lt;/p&gt;
Characterization of ASP8374, a fully-human, antagonistic anti-TIGIT monoclonal antibody (2021)

The T-cell immunoreceptor with Ig and immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT) is a validated immune checkpoint protein expressed on memory CD4<sup>+</sup>T-cellls, Tregs, CD8<sup>+</sup>T-cell and natural killer (NK) cells. ASP8374 is a fully human monoclonal immunoglobulin (Ig) G4 antibody designed to block the interaction of TIGIT with its ligands and inhibit TIGIT signaling. ASP8374 exhibited high affinity binding to TIGIT and increased interferon (IFN)-γ production of cultured peripheral blood mononuclear cells (PBMCs) in a titratable manner. When used in combination with pembrolizumab, an anti-programmed death-1 (PD-1) antibody, ASP8374 induced higher T-cell activation in vitro than either treatment alone. An anti-mouse TIGIT antibody surrogate, mSEC1, displayed anti-tumor efficacy in an MC38 syngeneic mouse tumor model alone and in combination with an anti-programmed death-ligand 1 (PD-L1) antibody. In an additional syngeneic mouse tumor model (CT26), while mSEC1 alone did not demonstrate anti-tumor efficacy, mSEC1 combined with an anti-PD-1 antibody enhanced anti-tumor efficacy above that of the anti-PD-1 antibody alone. These data provide evidence that ASP8374 has therapeutic potential for advanced malignancies.
Comparative study of intraperitoneal and intravenous vancomycin pharmacokinetics during continuous ambulatory peritoneal dialysis (1987)

The pharmacokinetic characteristics of vancomycin were investigated in eight patients undergoing continuous ambulatory peritoneal dialysis. A crossover design was used. Four noninfected patients received both a 15-mg/kg (body weight) intravenous dose and a 30-mg/kg intraperitoneal (i.p.) dose. Bioavailability ranged from 0.35 to 0.65 after i.p. administration. i.p. absorption was rapid, with concentrations in serum of 8.8 +/- 6 micrograms/ml noted at 1 h peak values of 30.4 +/- 7 micrograms/ml at 6 h. A slow distribution phase was apparent, with a terminal elimination phase emerging after 12 to 24 h. Vancomycin was eliminated slowly, with a mean total clearance of 5.0 +/- 1.3 ml/min, and concentrations in serum were 7.0 +/- 1.2 micrograms/ml at 168 h. The mean serum half-life was 91.7 +/- 28.1 h, and similar pharmacokinetics were noted after intravenous administration. Subsequently, four patients with catheter-related exit site or tunnel infections received a 30-mg/kg i.p. dose of vancomycin and displayed a similar kinetic pattern. This method of administering vancomycin achieved therapeutic serum and end-dwell dialysate concentrations over a 1-week period, represents a simple, cost-effective therapy which avoids the possibility of infusion-related toxicity, and deserves further investigation in patients with continuous ambulatory peritoneal dialysis-related peritonitis.
Insulin-related metabolism following hematopoietic stem cell transplantation in childhood (2008)

Attentive follow-up of insulin-related metabolism following HSCT in children is needed. The significance of the higher HbA1c values in the study group remains to be evaluated in a larger cohort of patients.
An imidazolium-substituted Pd3-cycloheptatrienyl sandwich complex (2012)

Cycloheptatrieneylidene (CHT)-palladium complexes can react with N-donor molecules, showing two different reaction pathways -Nucleophilic attack at the CHT-ligand or coordination to the metal center. A series of single crystal X-ray structures of the resulting products are presented, including an imidazolium-substitutedtripalladium-CHT sandwich complex.The latter possessesa Pd 3 -moiety, which is nearly coplanarily arrangedto each CHT-ring and h 1 -coordinated to each one of three bromine atoms.The Pd-Pd distances are within a range of 2.732 to 2.783 and the distance between the Pd 3 -and CHT-plane is 2.100 and 2.095, respectively. This structural motif has been reported only once with unsubstituted CHT-rings, indicating a formal oxidation state of Pd(I).
Fabrication of a silver nanowire-reduced graphene oxide-based electrochemical biosensor and its enhanced sensitivity in the simultaneous determination of ascorbic acid, dopamine, and uric acid (2015)

Silver nanowire/reduced graphene oxide nanocomposites (AgNW/rGO) are synthesized using a two-step process.
Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue (2018)

Assessment Of The Synaptic Interface Of Primary Human T Cells From Peripheral Blood And Lymphoid Tissue - Video. JoVE publishes peer-reviewed scientific video protocols to accelerate biological, medical, chemical and physical research. Watch our scientific video articles. JoVE is the world-leading producer and provider of science videos with the mission to improve scientific research, scientific journals, and education. Millions of scientists, educators and students at thousands of universities, colleges, hospitals and biopharmaceutical companies worldwide use JoVE for their research, teaching and learning.
The structure of baumycins A1, A2, B1, B2, C1 and C2. (1977)

In a previous paper, the isolation and physicochemical properties of new antitumor antibiotics, baumycins A1, A2, B1, B2, C1 and C2 were reported1).
Cool job allocation: measuring the power savings of placing jobs at cooling-efficient locations in the data center (2007)

Data center costs for computer power and cooling are staggering. Because certain physical locations inside the data center are more efficient to cool than others, this suggests that allocating heavy computational workloads onto those servers that are in more efficient places might bring substantial savings. This simple idea raises two critical research questions that we address: (1) How should one measure and rank the cooling efficiency of different places in a data center? (2) How substantial is the savings? We performed a set of experiments in a thermally isolated portion of a real data center, and validated that the potential savings is substantial and therefore warrants further work in this area to exploit the savings opportunity.
Greedy Feature Selection for Subspace Clustering (2013)

Unions of subspaces provide a powerful generalization to linear subspace models for collections of high-dimensional data. To learn a union of subspaces from a collection of data, sets of signals in the collection that belong to the same subspace must be identified in order to obtain accurate estimates of the subspace structures present in the data. Recently, sparse recovery methods have been shown to provide a provable and robust strategy for exact feature selection (EFS)--recovering subsets of points from the ensemble that live in the same subspace. In parallel with recent studies of EFS with L1-minimization, in this paper, we develop sufficient conditions for EFS with a greedy method for sparse signal recovery known as orthogonal matching pursuit (OMP). Following our analysis, we provide an empirical study of feature selection strategies for signals living on unions of subspaces and characterize the gap between sparse recovery methods and nearest neighbor (NN)-based approaches. In particular, we demonstrate that sparse recovery methods provide significant advantages over NN methods and the gap between the two approaches is particularly pronounced when the sampling of subspaces in the dataset is sparse. Our results suggest that OMP may be employed to reliably recover exact feature sets in a number of regimes where NN approaches fail to reveal the subspace membership of points in the ensemble.