gebhart/patrepeval huggingface dataset:
Static Self-Assembly (2016)

In the past, aggregation and self-assembly have been associated principally with micellar and colloidal systems of molecules; however, with the advent of supramolecular chemistry, molecular self-assembly has been opened to a much wider understanding that has facilitated access to a variety of different shapes and sizes, along with the construction of new and fascinating molecular topologies. This document aims at defining more than 150 terms related to aggregation and self-assembly in the particular case of macromolecules. The list is restricted to the most commonly encountered terms.
Design, Synthesis, and in vitro and in vivo Evaluations of (Z)‐3,4,5‐Trimethoxystyrylbenzenesulfonamides/sulfonates as Highly Potent Tubulin Polymerization Inhibitors (2017)

Newer therapeutics can be developed in drug discovery by adopting the strategy of scaffold hopping of the privileged scaffolds from known bioactive compounds. This strategy has been widely employed in drug-discovery processes. Structure-based docking studies illustrate the basic underlying concepts and reveal that interactions of the sulfonamide group and hydrophobic interactions are crucial. On the basis of this strategy, over 60 synthetic analogues were synthesized and evaluated for their cytotoxicity against the NCI panel of 60 human cancer cell lines; the majority of these compounds exhibited promising cytotoxicity with GI<sub>50</sub> values ranging between 18 and 50 nm. Among these compounds, (Z)-N-[2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl]-4-methoxybenzenesulfonamide (7 a) and (Z)-N-[2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl]-4-methoxybenzenesulfonamide (9 a) were found to be potent. Similar results were obtained against three human cancer cell lines with IC<sub>50</sub> values ranging between 0.04 and 3.0 μm. Studies aimed at elucidating the mechanism of action of these new analogues revealed that they inhibited the in vitro polymerization of tubulin and disorganized the assembly of microtubules in HeLa and MCF-7cancer cells. Lead compounds 7 a and 9 a displayed notable in vivo antitumor activity in a HeLa tumor xenograft model. Our studies have resulted in the identification of a scaffold that can target tubulin polymerization, which should have significant potential toward the development of new antitumor drugs.
1087: Phase I Trial of an Adjuvanted Recombinant Soluble Prostate-Specific Membrane Antigen (RSPSMA) Vaccine (2004)

You have accessJournal of UrologyDiscussed Poster, Monday, May 10, 2004, 1:00 - 5:00 pm1 Apr 20041087: Phase I Trial of an Adjuvanted Recombinant Soluble Prostate-Specific Membrane Antigen (RSPSMA) Vaccine Susan F. Slovin, Jason P. Gardner, Donna M. Morrissey, Jason P. Gardner, Gerald P. Donovan, Kenneth G. Surowitz, William C. Olson, Howard I. Scher, and Robert J. Israel Susan F. SlovinSusan F. Slovin More articles by this author , Jason P. GardnerJason P. Gardner More articles by this author , Donna M. MorrisseyDonna M. Morrissey More articles by this author , Jason P. GardnerJason P. Gardner More articles by this author , Gerald P. DonovanGerald P. Donovan More articles by this author , Kenneth G. SurowitzKenneth G. Surowitz More articles by this author , William C. OlsonWilliam C. Olson More articles by this author , Howard I. ScherHoward I. Scher More articles by this author , and Robert J. IsraelRobert J. Israel More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)38324-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1087: Phase I Trial of an Adjuvanted Recombinant Soluble Prostate-Specific Membrane Antigen (RSPSMA) Vaccine." The Journal of Urology, 171(4S), pp. 286–287 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 286-287 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Susan F. Slovin More articles by this author Jason P. Gardner More articles by this author Donna M. Morrissey More articles by this author Jason P. Gardner More articles by this author Gerald P. Donovan More articles by this author Kenneth G. Surowitz More articles by this author William C. Olson More articles by this author Howard I. Scher More articles by this author Robert J. Israel More articles by this author Expand All Advertisement PDF DownloadLoading ...
ChemInform Abstract: CATALYTIC USES OF IRON PENTACARBONYL: FORMATION OF CARBOXYLIC ACID DERIVATIVES (1984)

Abstract Aus Alkyl‐ und Aralkyl‐halogeniden (I) erhält man bei der Behandlung mit CO und Alkoholen in Gegenwart von Eisenpentacarbonyl und Pottasche die Ester (IV).
Faltungscodes (1995)

Nachdem Verfahren der Blockcodierung von Hamming, Golay (1949) und anderen vorgeschlagen, untersucht und praktisch eingesetzt wurden, publizierte Elias 1955 erste Arbeiten zu Faltungscodes. Bei diesen Codiermethoden wird die Eingangsbitfolge in einer faltungsähnlichen Operation verarbeitet und den Nutzdaten auf diese Weise Redundanz hinzugefügt. Im Gegensatz zu Blockcodes, bei denen jeweils Codeworte der festen Länge N gebildet und den n Nachrichtenstellen jeweils k Kontrollstellen hinzugefügt werden, wird bei Faltungscodes eine kontinuierliche Verarbeitung durchgeführt. Das in dem Faltungscode entstehende Verhältnis zwischen Nutzdaten- und Redundanzanteil wird wiederum wie bei Blockcodes durch die noch zu definierende Coderate R bestimmt.
Frequency-modulated microwave photonic links for high dynamic-range antenna remoting systems (2011)

To support the need to distribute analog signals from microwave antennas dispersed throughout military aircraft, much research has been devoted to developing microwave photonic links (MPLs) with very high linearity and low noise figures. Frequency-modulated (FM) photonic links are a promising technology to provide high dynamic-range signal transmission for these airborne antenna remoting systems. FM lasers, where a phase modulator in the optical cavity varies the optical frequency with applied RF power, have been demonstrated with very high modulation efficiency. Demodulation performed using an optical filter based frequency discriminator and direct detection (FM-DD) (also called slope or interferometric detection) can be engineered for low nonlinearities by optimizing the transfer function of the filter. The combination of a high efficiency FM laser with a discriminator filter for low-distortion demodulation leads to a MPL with signal gain, low noise figure and large dynamic range.
Retinal Vessel Analysis as a Tool to Quantify Risk of Diabetic Retinopathy (2012)

Diabetic retinopathy remains a leading cause of visual impairment and blindness worldwide. Identifying high-risk asymptomatic individuals who will likely develop the sight-threatening forms of diabetic retinopathy is an important clinical goal as it allows early, targeted implementation of preventive strategies to reduce their risk of vision loss. However, diabetic retinopathy is not a linear disease. Predicting the risk of diabetic retinopathy is challenging, and the current approach simply based on an assessment of traditional risk factors lacks precision. Retinal vessel analysis may offer a novel and noninvasive tool to improve risk prediction for diabetic retinopathy. With the use of this technology, studies have shown that a spectrum of structural alterations in the retinal vasculature can now be reliably quantified. In particular, variations in retinal vessel caliber have been consistently associated with the risks of retinopathy development and progression and shown to have prognostic predictive value above and beyond the conventional risk factors. Despite the promising results, there remain several unresolved issues that need to be addressed before the research findings on retinal vessel analysis are translated into clinical application. Coupling with standard clinical assessment, the additional information obtained from this technology could potentially guide clinical decision making, patient prognostication, and possibly monitor therapeutic response.
Patterns of chemotherapy near the end of life for patients receiving palliative bone radiotherapy. (2014)

9544 Background: Appropriate timing of chemotherapy (CT) cessation is important for optimizing quality of life, with consensus guidelines recommending termination of CT within the last 2-4 weeks of life. Yet CT near the end of life is used in 10-30% of patients, often with little realistic chance of benefit (Kelly R, Smith TJ. Lancet Oncology 2014). We review patterns of CT at the end of life among patients receiving palliative bone radiation (RT) at a high-volume academic institution. Methods: Electronic medical records were used to identify patients treated with palliative bone RT at 2 centers from 9/1/2007-7/15/2012. Patient demographics and last recorded systemic (hormonal, non-hormonal oral, and non-hormonal IV) therapy characteristics were collected, and rates of CT in the last 2 and 4 weeks of life were calculated. Factors were compared using χ2and ANOVA analyses. Results: Complete records were found for 210 patients, and 92% were deceased at the time of analysis. Among decedents, median age at death was 64 years (22-94), and primary was 36% lung, 15% breast, 13% prostate, 5% hematologic, and 31% other sites. 12% never received CT, and 30% and 13% received CT <4 weeks and <2 weeks from death. Primary site of disease for patients receiving CT <4 weeks from death were 25% lung, 17 % breast, 19% prostate, 8% hematological, and 31% other cancers; there was no significant difference in site between patients receiving CT <4 vs. ≥4 weeks or <2 or ≥2 weeks from death. Type of CT did not significantly vary relative to time until death; CT <4 and <2 weeks from death was 53% and 52% IV, 31% and 36% oral, and 17% and 12% hormonal, respectively. 16% and 7% of all patients received IV CT <4 weeks and <2 weeks from death, respectively. Patients referred to hospice were less likely to receive CT <4 and <2 weeks from death (χ2 p=0.003 and p=0.001, respectively). There was no difference in time-to-death from date of last CT based on cancer primary or CT type. Conclusions: Of patients receiving palliative bone RT, rates of CT at the end of life are relatively low, using the Quality Oncology Practice Initiative benchmarks. Chemotherapy use at the end of life is lowest among patients referred to hospice, supporting engagement of hospice in terminally ill patients.
Algebraic lattice alignment for K-user interference channels (2009)

This paper develops a new achievable region for the K-user symmetric interference channel using algebraic interference alignment. Our scheme uses lattice codebooks to transform the interference channel into an equivalent noiseless discrete-alphabet additive interference channel. Subsequently, algebraic alignment schemes are used to characterize the achievable rates for this channel.
Genetically Encoded Fluorescent Probe for Detecting Sirtuins in Living Cells (2017)

Sirtuins are NAD<sup>+</sup> dependent protein deacetylases, which are involved in many biological processes. We now report a novel genetically encoded fluorescent probe (EGFP-K85AcK) that responds to sirtuins in living cells. The probe design exploits a lysyl residue in EGFP that is essential for chromophore maturation, and is also an efficient deacetylation substrate for sirtuins. Analysis of activity in Escherichia coli ΔcobB revealed that the probe can respond to various human sirtuins, including SIRT1, SIRT2, SIRT3 and SIRT5. We also directly monitored SIRT1 and SIRT2 activity in HEK293T cells with an mCherry fusion of EGFP-K85AcK, and showed that this approach can be extended to other fluorescent proteins. Finally, we demonstrate that this approach can be used to examine the activity of sirtuins toward additional lysyl posttranslational modifications, and show that sirtuins can act as erasers of HibK modified proteins.
Decreased serum pyridoxal levels in schizophrenia: meta-analysis and Mendelian randomization analysis (2018)

We found decreased serum pyridoxal levels in patients with schizophrenia in this observational study. However, we failed to obtain data supporting a causal relationship between pyridoxal levels and schizophrenia risk using the MR approach.
Symbol timing estimation in ultra wideband communications (2003)

This paper takes on a cyclostationary approach to recover timing of ultra-wideband (UWB) transmissions over rich multipath environments. It is demonstrated that timing dependent cyclic statistics exist without resorting to oversampling, due to the symbol repetition pattern inherent to UWB modulation. Based on the received signal's second-order cyclic statistics, non-data-aided time offset estimation algorithms are developed. Timing acquisition relies only on frame rate samples, while low-complexity tracking utilizes pulse rate samples. Both acquisition and tracking schemes are tolerant to UWB channel fading, and additive stationary (possibly colored) noise.
WIPR Public Key Identi cation on Two Grains of Sand (2008)

We revisit a public key scheme presented by Shamir in [16] (and simultaneously by Naccache in [12]) and examine its applicability for general-purpose RFID tags in the supply chain. Using a combination of new and established space-saving methods, we present WIPR a fulledged public key identi cation scheme which is secure yet highly e cient. 1024-bit WIPR ts completely (including RAM) into 5705 gate equivalents and has a mean current consumption of 10.88μA. The main novelty in our implementation is the replacement of the long pseudorandom sequence, originally stored on EEPROM in [16], by a reversible stream cipher using less than 300 bits of RAM. We show how our scheme can be extended to o er tag-to-reader and reader-to-tag authentication and how it can be t into the existing RFID supply chain infrastructure.
Functional-Group-Dependent Formation of Bioactive Fluorescent-Plasmonic Nanohybrids (2016)

We detail the assembly, driven by metal-affinity coordination, of fluorescent-plasmonic hybrid constructs that are also biologically active. The hybrid constructs are prepared by first assembling polymer-encapsulated luminescent quantum dots that present amine-, carboxy-, and lipoic acid-terminated groups (QD-FG) and plasmonic gold nanoparticles capped with rather low density of lipoic acid-appended zwitterion ligands (AuNP-LA-ZW). The dual QD-AuNP constructs were then coupled to polyhistidine-appended maltose binding proteins, yielding the final trifunctional assemblies. The coordination of amine-, carboxy-, and lipoic acid-terminated QDs with AuNP-LA-ZW was characterized using steady-state and time-resolved fluorescence quenching measurements. We measured rather different coordination affinities between the functional groups on the QDs and the AuNP surfaces. This assembly mode still allowed the partially exposed AuNPs in the inorganic/polymer hybrid to bind to polyhistidine-appended proteins. This protein assembly was confirmed using amylose affinity chromatography, which also confirmed the structural integrity of the hybrid and biological activity of the bound protein. Owing to the high colloidal stability of the surface-modified QDs and AuNP-LA-ZW, combined with flexible functionalization, we anticipate that this strategy could facilitate the integration of hybrid inorganic/polymer constructs with specific photophysical properties into biological systems.
A Collision Warning Oriented Brake Lights Detection and Classification Algorithm Based on a Mono Camera Sensor (2019)

In this paper, a brake lights detection and classification algorithm based on a monocular camera and oriented to collision warning is described. First, the current driving lane is identified through a lane detection algorithm. Shrinking the search area to the actual driving lane, the preceding vehicle is detected exploiting YOLO object detector. Then, preceding vehicle lateral and third brake lights are identified in the L <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">*</sup> a <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">*</sup> b colorspace by harnessing brightness and color information, along with geometrical considerations. Finally, brake lights status is determined by means of SVMs classifiers, based on features computed both on light regions and the overall vehicle image, and the braking status of the preceding vehicle is determined. The algorithm is designed to work in different illumination conditions during day time: experimental results prove the robustness of the proposed strategy with respect to different illumination conditions and brake lights shape, with an overall algorithm precision of 96.3%.
Abstract 1209: Istiratumab (MM-141), a bispecific antibody targeting IGF-1R and ErbB3, inhibits pro-survival signaling in vitro and potentiates the activity of standard of care chemotherapy in vivo in ovarian cancer models (2016)

Abstract Insulin-like growth factor receptor 1 (IGF-1R) signaling has been implicated in the pathogenesis of ovarian cancer. However, clinical trials evaluating monospecific IGF-1R inhibitors have demonstrated limited clinical efficacy. Our data indicate that ErbB3, a member of the ErbB receptor tyrosine kinase family, can activate pro-survival AKT signaling in response to IGF-1R blockade and may represent a potential escape route in the development of resistance to therapy. Istiratumab (MM-141), an IGF-1R and ErbB3 directed bispecific antibody, inhibits ligand activation of these signaling pathways and degrades IGF-1R and ErbB3 receptor-containing complexes, leading to inhibition of downstream pro-survival signaling. Here we tested the activity of istiratumab, alone and in combination with chemotherapy, in in vitro and in vivo models of ovarian cancer. Anti-proliferative activity of istiratumab monotherapy was evaluated in a panel of ovarian cancer cell lines in vitro. The effects of istiratumab and the ligands IGF-1 and heregulin on IGF-1R- and ErbB3-mediated survival signaling were tested by ELISA and immunoblotting. Co-treatment assays with istiratumab and chemotherapy investigated mechanisms of synergy and additivity. Anti-tumor activity of istiratumab, alone and in combination with chemotherapy, was tested in in vivo ovarian xenograft tumor models. Our results indicated that istiratumab monotherapy inhibits ovarian cancer cell line proliferation in vitro. In addition, istiratumab blocked ligand-mediated resistance to chemotherapy. Co-treatment of istiratumab, ligands or chemotherapy indicated a strong correlation between drug activity and IGF-1R expression. Furthermore, co-treatment of chemotherapies and ligands potentiated AKT activation, which was inhibited by istiratumab. In vivo studies showed that istiratumab potentiates the activity of chemotherapy in ovarian xenograft tumor models. Our findings demonstrate that co-inhibition of IGF-1R and ErbB3 signaling with istiratumab can potentiate standard of care chemotherapies in ovarian tumor models and warrant further investigation of istiratumab as a potential therapy for ovarian cancer patients. Citation Format: Michael D. Curley, Gege Tan, Isabel Yannatos, Adam Camblin, Sergio Iadevaia, Chrystal Louis, Alexey Lugovskoy. Istiratumab (MM-141), a bispecific antibody targeting IGF-1R and ErbB3, inhibits pro-survival signaling in vitro and potentiates the activity of standard of care chemotherapy in vivo in ovarian cancer models. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1209.
Low Accuracy of FIB-4 and NAFLD Fibrosis Scores for Screening for Liver Fibrosis in the Population (2021)

FIB-4 and NFS are suboptimal for screening purposes due to a high risk of overdiagnosis and a non-negligible percentage of false-negatives, especially in patients with risk factors for chronic liver disease. Waist circumference emerged as a potential first step to identify patients at risk for liver fibrosis in the general population.
Overall survival in lower IPSS risk MDS by receipt of iron chelation therapy, adjusting for patient‐related factors and measuring from time of first red blood cell transfusion dependence: an MDS‐CAN analysis (2017)

Analyses suggest iron overload in red blood cell (RBC) transfusion-dependent (TD) patients with myleodysplastic syndrome (MDS) portends inferior overall survival (OS) that is attenuated by iron chelation therapy (ICT) but may be biassed by unbalanced patient-related factors. The Canadian MDS Registry prospectively measures frailty, comorbidity and disability. We analysed OS by receipt of ICT, adjusting for these patient-related factors. TD International Prognostic Scoring System (IPSS) low and intermediate-1 risk MDS, at RBC TD, were included. Predictive factors for OS were determined. A matched pair analysis considering age, revised IPSS, TD severity, time from MDS diagnosis to TD, and receipt of disease-modifying agents was conducted. Of 239 patients, 83 received ICT; frailty, comorbidity and disability did not differ from non-ICT patients. Median OS from TD was superior in ICT patients (5·2 vs. 2·1 years; P < 0·0001). By multivariate analysis, not receiving ICT independently predicted inferior OS, (hazard ratio for death 2·0, P = 0·03). In matched pair analysis, OS remained superior for ICT patients (P = 0·02). In this prospective, non-randomized analysis, receiving ICT was associated with superior OS in lower IPSS risk MDS, adjusting for age, frailty, comorbidity, disability, revised IPSS, TD severity, time to TD and receiving disease-modifying agents. This provides additional evidence that ICT may confer clinical benefit.
Additively manufactured transparent ceramic thin disk gain medium (2022)

A novel type of Yb:YAG transparent ceramic thin disk laser amplifier is demonstrated, based on fabricating a composite gain element with a paraboloidal interface between gain and no-gain regions and employing side-pumping of the thin disk. The pump-induced gain and the impact of amplified spontaneous emission on the achievable inversion are reported.
A Searchlight Factor Model Approach for Locating Shared Information in Multi-Subject fMRI Analysis (2016)

There is a growing interest in joint multi-subject fMRI analysis. The challenge of such analysis comes from inherent anatomical and functional variability across subjects. One approach to resolving this is a shared response factor model. This assumes a shared and time synchronized stimulus across subjects. Such a model can often identify shared information, but it may not be able to pinpoint with high resolution the spatial location of this information. In this work, we examine a searchlight based shared response model to identify shared information in small contiguous regions (searchlights) across the whole brain. Validation using classification tasks demonstrates that we can pinpoint informative local regions.