gebhart/patrepeval huggingface dataset:
Route to Stable Lead-Free Double Perovskites with the Electronic Structure of CH3NH3PbI3: A Case for Mixed-Cation [Cs/CH3NH3/CH(NH2)2]2InBiBr6 (2017)

During the past year, halide double perovskites attracted attention as potential lead-free alternatives to Pb-based halide perovskites. However, none of the compounds discovered so far can match the optoelectronic properties of MAPbI<sub>3</sub> (MA = CH<sub>3</sub>NH<sub>3</sub>). Here we argue that, from the electronic structure viewpoint, the only option to make Pb-free double perovskites retaining the remarkable properties of MAPbI<sub>3</sub> is to combine In and Bi as B<sup>+</sup> and B<sup>3+</sup> cations, respectively. While inorganic double perovskites such as Cs<sub>2</sub>InBiX<sub>6</sub> were found to be unstable due to In<sup>+</sup> oxidizing into In<sup>3+</sup>, we show that the +1 oxidation state of In becomes progressively more stable as the A-site cation changes from K to Cs. Hence, we propose the use of MA and FA [FA = CH(NH<sub>2</sub>)<sub>2</sub>] to stabilize A<sub>2</sub>InBiBr<sub>6</sub> double perovskites. We show that the optoelectronic properties of MA<sub>2</sub>InBiBr<sub>6</sub> are remarkably similar to those of MAPbI<sub>3</sub> and explore the mixed-cation (Cs/MA/FA)<sub>2</sub>InBiBr<sub>6</sub> halide double perovskites.
Spine-shaped gold protrusions improve the adherence and electrical coupling of neurons with the surface of micro-electronic devices (2009)

Interfacing neurons with micro- and nano-electronic devices has been a subject of intense study over the last decade. One of the major problems in assembling efficient neuro-electronic hybrid systems is the weak electrical coupling between the components. This is mainly attributed to the fundamental property of living cells to form and maintain an extracellular cleft between the plasma membrane and any substrate to which they adhere. This cleft shunts the current generated by propagating action potentials and thus reduces the signal-to-noise ratio. Reducing the cleft thickness, and thereby increasing the seal resistance formed between the neurons and the sensing surface, is thus a challenge and could improve the electrical coupling coefficient. Using electron microscopic analysis and field potential recordings, we examined here the use of gold micro-structures that mimic dendritic spines in their shape and dimensions to improve the adhesion and electrical coupling between neurons and micro-electronic devices. We found that neurons cultured on a gold-spine matrix, functionalized by a cysteine-terminated peptide with a number of RGD repeats, readily engulf the spines, forming tight apposition. The recorded field potentials of cultured Aplysia neurons are significantly larger using gold-spine electrodes in comparison with flat electrodes.
A facile method for the deposition of volatile natural compound-based nanoparticles on biodegradable polymer surfaces (2018)

In the current work, stable nanoparticles (NPs) of vanillin are formed in situ from an aqueous/ethanol solution and deposited on the surface of chitosan, a natural polymer, using a high-intensity ultrasonic method. The spectroscopic, physical, mechanical and morphological properties of the coated chitosan films are examined by helium-ion microscopy (HIM), atomic-force microscopy (AFM), Fourier-transform infrared spectroscopy (FTIR), UV-vis spectroscopy, X-ray diffractometry (XRD), thermal gravimetric analysis (TGA), differential scanning calorimetry (DSC) and texture analysis, and compared with the original film properties. Vanillin NPs were detected on the film surface. It was also found that the sonochemical deposition method does not affect the bulk properties of the chitosan films. All the chitosan films demonstrated antimicrobial activity against Gram-negative and Gram-positive bacteria. The deposition of vanillin NPs on the chitosan film also leads to significant antibiofilm activity, especially against the biofilm formation of Escherichia coli bacteria. The in vivo antimicrobial effect of the modified chitosan films was examined on fresh-cut watermelon, melon and strawberry. Vanillin NP-coated chitosan films led to inhibition of total microbial growth and the substantial inhibition of mold and yeast on the fruit. This research can serve as a platform for the development of a mild and effective method for the activation and modification of natural polymers for their future application in biomedical devices and biodegradable active packaging materials.
Acquisition, traitement du signal électrocardiographique et détection automatique de la fibrillation ventriculaire (1990)

Texte intégral accessible uniquement aux membres de l'Université de Lorraine jusqu'au 2034-06-24
Automatic Content Repurposing for Mobile Applications (2010)

The automatic content repurposing solution proposed, enables broadcasters to adapt traditional content to the specific constraints of handheld devices, both automatically and in realtime. The goal is to provide customers with the best possible viewing experience. Automatic content repurposing solution rests mainly on the dynamic reframing (also called retargeting) of content. It aims at identifying the regions of interest and zooming in on these regions. Although initially dedicated to mobile TV, this solution could also target broadcast, PDAs, portable devices, or internet and web publishing. Thanks to this new and unique approach, broadcasters and content owners now have the ability to adapt content for multiple distribution platforms in a cost-effective way. Compared to the classical approach, the proposed reframing solution delivers a superior viewing experience by focusing on the most visually interesting areas. Based on a human visual model, this unique solution dramatically reduces the repurposing tasks.
FTC: A Universal Sensor for Fault Injection Attack Detection (2022)

Over the past two decades, fault-injection methods have evolved into very effective attacks to cause integrity or con-fidentiality violations in integrated circuits or electronic systems. Fault-injection attacks (FIAs) can be carried out using clock-glitch, voltage glitch, laser, optical instruments, electromagnetic (EM) emanation, and more. One promising solution to detect FIAs is to use on-chip sensors to capture the attacks' effect. However, having different types and techniques of FIAs enforces using the custom-designed sensors for each type of attack, which is challenging and introduces a large overhead. To address this, in this paper, we propose to develop a universal Fault-to- Time Converter (FTC) sensor that can effectively detect all the above-mentioned FIAs while requiring minimal overhead. The FTC sensor converts the effect of faults injected by an FIA method into “time” that is measurable. Then, the “time” difference can be analyzed further to identify whether an attack has been carried out successfully. Our FTC sensor implementation in FPGA platforms demonstrates that the design can effectively differentiate various FIA attack scenarios with its encoded output. The FTC sensor can also be extended to cover other fault attacks that have a similar impact on the victim device (i.e., affecting circuit timing).
Unusual Presentation of Traumatic Neuroma on the Gingiva Following a Road Traffic Accident - A Case Report (2021)

Traumatic neuroma is a tumour-like swelling, characterized by localized reactive proliferation of the peripheral nerve occurring in response to transection or other damage to the nerve bundles. It represents an ineffective attempt at nerve repair following trauma that results in degeneration of the nerve followed by nerve axon regeneration and remyelination within the dense fibrous connective tissue stroma. N rarely occurs in the oral cavity; 4 however, it has been noted in the area of the mental foramen, lower lip and tongue. Only few cases of TN have been described on the palate. Tamiolakis et al have reported the prevalence of oral neural tumours to be 0.4 % out of 35,590 collected biopsies. Only 25 cases were diagnosed as traumatic neuroma out of the total number of biopsies. None of the reported TN cases were from the gingiva region. 8 To our knowledge, there have been no previous reports of a TN in the region of the gingiva with an atypical clinical appearance.
Dual-release formulation, a novel principle in l -dopa treatment of Parkinson’s disease (2001)

A single morning dose of dual-release formulation was compared with a slow-release formulation of L-dopa plus benserazide in a randomized, double-blind, cross-over study in 16 fluctuating patients with PD. The mean time to "on" was shorter with the dual-release formulation (43 +/- 31 minutes) than with the slow-release formulation (81 +/- 39 minutes) (p < 0.001), whereas the mean time to relapse to "off" was similar for both formulations. The dual-release formulation had a significantly shorter time to reach peak concentration (t(max)) and greater maximum concentration (C(max)) and area under the plasma concentration time curve (AUC(0--5 h)) than the slow-release formulation, whereas apparent elimination half-life (t(1/2)) was similar for both formulations.
Engineering dynamical control of cell fate switching using synthetic phospho-regulons (2016)

Many cells can sense and respond to time-varying stimuli, selectively triggering changes in cell fate only in response to inputs of a particular duration or frequency. A common motif in dynamically controlled cells is a dual-timescale regulatory network: although long-term fate decisions are ultimately controlled by a slow-timescale switch (e.g., gene expression), input signals are first processed by a fast-timescale signaling layer, which is hypothesized to filter what dynamic information is efficiently relayed downstream. Directly testing the design principles of how dual-timescale circuits control dynamic sensing, however, has been challenging, because most synthetic biology methods have focused solely on rewiring transcriptional circuits, which operate at a single slow timescale. Here, we report the development of a modular approach for flexibly engineering phosphorylation circuits using designed phospho-regulon motifs. By then linking rapid phospho-feedback with slower downstream transcription-based bistable switches, we can construct synthetic dual-timescale circuits in yeast in which the triggering dynamics and the end-state properties of the ON state can be selectively tuned. These phospho-regulon tools thus open up the possibility to engineer cells with customized dynamical control.
The endogenous danger signal, crystalline uric acid, signals for enhanced antibody immunity (2007)

Studies have shown that the immune system can recognize self-antigens under conditions (eg, cell injury) in which the self-tissue might elaborate immune-activating endogenous danger signals. Uric acid (UA) is an endogenous danger signal recently identified to be released from dying cells. Prior work has shown that UA activates immune effectors of both the innate and adaptive immune system, including neutrophils and cytotoxic T-cell immunity. However, it was unclear whether UA could enhance antibody immunity, which was examined in this study. When added to dying tumor cells or with whole protein antigen, UA increased IgG1-based humoral immunity. Further, UA blocked growth of tumor in subsequent tumor challenge experiments, which depended on CD4, but not CD8, T cells. Sera derived from UA-treated animals enhanced tumor growth, suggesting it had little role in the antitumor response. UA did not signal for T-cell expansion or altered tumor-infiltrating leukocyte populations. Consistent with the lack of T-cell expansion, when applied to dendritic cells, UA suppressed T-cell growth factors but up-regulated B cell-activating cytokines. Understanding the nature of endogenous danger signals released from dying cells may aid in a better understanding of mechanisms of immune recognition of self.
Cluster and periodic ab initio study of the ethane-ethene hydride transfer reaction catalyzed by acid chabazite. Is the cluster model able to describe accurately the host–guest interactions? (1999)

The ethane–ethene hydride transfer reaction on acid chabazite is used to test the performance of cluster calculations with respect to periodic ones for the study of bimolecular hydrocarbon reactions on acid zeolites. The following computational levels are considered: Hartree–Fock, MP2, aposteriori density functional theory (DFT) correlation using the PW91 functional, and several DFT hybrid B3PW91 procedures with different percentages of Hartree–Fock exchange. In all cases, a polarized basis set of double-zeta quality is used. Three periodic models with different numbers of acid sites and adsorbed substrates are explored to account for the effect of Si:Al ratio and coverage. Cluster and periodic calculations at different computational levels have been performed using the local geometries obtained from cluster constrained optimizations at the B3PW91 level. Our results indicate that the electrostatic field generated by the crystalline framework has only a relative influence on the stability of charged intermediates, that depends on the coverage and composition of the model, and also on the computational method used. It is noted in particular that the additional stability provided by the crystalline Madelung potential on the charged intermediate increases with the percentage of Hartree–Fock exchange in the DFT hybrid B3 scheme.
Understanding negotiation in airtime sharing in low-income microenterprises (2012)

Shared access to airtime is a prominent mode of connectivity access in the developing world. We seek to understand airtime sharing among low-income microenterprises in India (small, low-capital businesses, such as flower sellers and milkmen), that constitute 90% of the total enterprises in India. We introduce social negotiation as the foundation of airtime sharing. We highlight negotiation mechanisms in the microenterprise, showing how shared resources are used towards personal interests amidst tensions and value conflicts, by adapting, modifying, subverting, and repurposing airtime. We then explore the design space of airtime and bandwidth sharing in low-income communities, including designing for negotiation and improving readability of airtime.
The effectiveness of e-healthcare interventions for mental health of nurses (2022)

In conclusion, there was some evidence that e-healthcare interventions may improve mental health outcomes, including burnout in nurses, compared with no intervention. However, due to the poor methodological quality and wide heterogeneity of the interventions and outcomes in the included studies, we were not able to reach sufficiently reliable conclusions. E-healthcare intervention for nurses in the new coronavirus disease era was discussed. High-quality clinical trials in this area should be conducted in the future.
Ergodic Dynamics of the Coupled Quasigeostrophic Flow-Energy Balance System (2004)

The authors consider a mathematical model for the coupled atmosphere-ocean system, namely, the coupled quasigeostrophic flow-energy balance model. This model consists of the large scale quasigeostrophic oceanic flow model and the transport equation for oceanic temperature, coupled with an atmospheric energy balance model. After reformulating this coupled model as a random dynamical system (cocycle property), it is shown that the coupled quasigeostrophic-energy balance fluid system has a random attractor, and under further conditions on the physical data and the covariance of the noise, the system is ergodic, namely, for any observable of the coupled atmosphere-ocean flows, its time average approximates the statistical ensemble average, as long as the time interval is sufficiently long.
Effect of CCR3 inhibitors on allergic airway responses in ascaris-sensitized cynomolgus monkeys (2012)

Aim: CCR3 has historically been associated with the functional responses of eosinophils in various models of allergic disease. The goal of this study was to determine whether pre-treatment with CCR3 inhibitors via oral and inhaled routes attenuates asthma responses in ascaris sensitized Cynomolgus monkeys. Methods: Animals received a CCR3 antagonist given orally (AP0), or by inhalation (AR1) once or twice a day for 10 or up to 21 days prior to inhaled ascaris challenge. Changes in airway function (immediate and methacholine [MCh]) and inflammation (BAL & blood cells) were evaluated. Results: Oral (AP0 5 mg/kg; BID 10 days) or inhaled (AR1 860 μg; BID 7 days) treatment showed a trend towards a reduced immediate ascaris and MCh response but did not reach statistical significance. A longer oral treatment (AP0 3 mg/kg; QD 20 days) resulted in a significant reduction in both immediate bronchoconstriction and AHR. This was not associated with a consistent effect on BAL or blood eosinophils, but reduced the lymphocyte, macrophage and mast cell numbers. AP0 given in combination with inhaled fluticasone (79 μg BID) did not yield in a significant additive or synergistic effect on airway function but did lead to a greater reduction in BAL and blood eosinophils than AP0 or fluticasone alone. Conclusion: Treatment with a CCR3 inhibitor in the non-human primates, Ascaris model of asthma, shows that a number of critical parameters can be affected which are significantly different to alterations in the recruitment of eosinophils. Overall, these observations suggest that CCR3 inhibition may have more globally-beneficial responses in an asthmatic setting than previously appreciated.
Sex‐specific extent and severity of white matter damage in multiple sclerosis: Implications for cognitive decline (2013)

Cognitive dysfunction is common in multiple sclerosis (MS). However, the relationship between white matter (WM) damage and cognition remains insufficiently clear. This study investigates the extent and severity of WM diffusion abnormalities in MS patients and relations with cognition. Diffusion tensor imaging scans were obtained in 131 MS patients (88 women, 6 years postdiagnosis) and 49 age-matched controls (29 women). Patient groups were equal in terms of disease duration, disability, and WM lesion volume. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were compared between groups. Post hoc analyses calculated the spatial extent and severity of diffusion abnormalities to relate these to cognitive performance. In controls, 31% of WM voxels showed higher FA in men; therefore, all patient analyses were within-sex. The extent of diffusion changes was higher in male patients than in female patients for all parameters (FA: 24% in women, 53% in men), as was the severity of changes (FA: Z = -0.18 in women, Z = -0.41 in men). Especially the extent of FA abnormalities was strongly related to cognitive performance in all patients (r = -0.42, P < 0.0001). Regionally, thalamic decreases in FA were especially correlated with cognitive performance. Cognitively impaired patients showed greater extent and severity on all diffusion parameters compared to cognitively preserved patients. The WM of male patients was both more extensively and also more severely affected than that of female patients. The extent of WM FA changes, especially in the thalamus, was associated with cognitive performance in this cohort of early MS patients.
Halogen Versus Hydrogen (2008)

Use of noncovalent interactions involving halogen atoms opens up new ways to manipulate molecular recognition processes.
Sequential dual-curing of electron-deficient olefins and alcohols relying on oxa-Michael addition and anionic polymerization (2023)

Polymer networks were obtained by anionic copolymerization of diacrylates and sub-stoichiometric amounts of diols using Lewis base catalysis.
Impact and compensation of sample clock offset on up-link SC-CDMA (2005)

Single-carrier code division multiple access (SC-CDMA), also named cyclic-prefix CDMA in the literature, is a promising air interface for the up-link of the 4G cellular wireless communication systems. It enables the high capacity intrinsically offered by CDMA by making the equalization of the multi-path channels and the mitigation of the resulting interference possible at a low complexity. This paper studies the impact of multi-user sample clock offset on the performance of up-link SC-CDMA and proposes a compensation strategy at the receiver. It is shown that clock offset leads to an unacceptable degradation of the performance if it is not compensated. In a simultaneous multi-user up-link system, the sample clock offset is usually pre-compensated at the transmitters. This paper demonstrates that the compensation can also be done at the receiver. In a first step the optimal linear multi-user joint detector is designed according to the MMSE criterion, taking the effect of clock offset into account. In a second step the MMSE joint detector is simplified to a low complexity detector incurring a negligible loss of performance
Automatic categorization of diverse experimental information in the bioscience literature (2012)

Our methods are applicable to a variety of data types with training set containing several hundreds to a few thousand documents. It is completely automatic and, thus can be readily incorporated to different workflow at different literature-based databases. We believe that the work presented here can contribute greatly to the tremendous task of automating the important yet labor-intensive biocuration effort.
Data from Robust Antitumor Immunity in a Patient with Metastatic Colorectal Cancer Treated with Cytotoxic Regimens (2023)

&lt;div&gt;Abstract&lt;p&gt;Microsatellite-stable (MSS) colorectal cancers are characterized by low mutation burden and limited immune-cell infiltration and thereby respond poorly to immunotherapy. Here, we report a case of metastatic MSS colorectal cancer with a robust anticancer immune response. The primary tumor was resected in 2012, and the patient received several cycles of chemotherapy until 2017. In 2018, the patient underwent a left hepatectomy to remove a new metastasis. Analysis of the metastatic tumor revealed a strong CD8&lt;sup&gt;+&lt;/sup&gt; T-cell response. A high frequency of CD8&lt;sup&gt;+&lt;/sup&gt; T cells coexpressed CD39 and CD103, a phenotype characteristic of tumor-reactive cells. Using whole-exome sequencing, we identified somatic mutations that generated peptides recognized by CD39&lt;sup&gt;+&lt;/sup&gt;CD103&lt;sup&gt;+&lt;/sup&gt;CD8&lt;sup&gt;+&lt;/sup&gt; T cells. The observed reactivity against the tumor was dominated by the response to a single mutation that emerged in the metastasis. Somatic mutations that were not immunogenic in the primary tumor led to robust CD8&lt;sup&gt;+&lt;/sup&gt; T-cell expansion later during disease progression. Our data suggest that the cytotoxic treatment regimen received by the patient might be responsible for this effect. Hence, the capacity of cytotoxic regimens to prime the immune system in colorectal cancer patients should be investigated further and might provide a rationale for combination with immunotherapy.&lt;/p&gt;&lt;/div&gt;
Singular Points in the Impurity Induced Far Infrared Absorption in KI (1975)

Low temperature, high resolution measurements of the far infrared absorption due to Na + , Br − and Cl − substitutional impurities in KI are presented. The continuous spectra are dominated by sharp features, some of which can be related to Van Hove singularities in the phonon spectrum of KI. This is confirmed by comparing the experimental spectra with theoretical calculations using a relaxation model for the defect and a shell model based on neutron spectroscopy for the phonons. While excellent agreement between experiment and theory is found for KI:Na + , agreement is not as good for the other systems. The model cannot account for additional peaks seen in the Br − induced spectra and also fails to account for the apparent reversal of a singularity type seen in KI:Cl − spectra.