gebhart/patrepeval huggingface dataset:
Functional Analysis of CXCR3 Splicing Variants and Their Ligands Using NanoBiT-Based Molecular Interaction Assays (2023)

CXCR3 regulates leukocyte trafficking, maturation, and various pathophysiological conditions. Alternative splicing generates three CXCR3 isoforms in humans. Previous studies investigated the roles of CXCR3 isoforms, and some biochemical data are not correlated with biological relevance analyses. RT-PCR analyses indicate that most cells express all three splicing variants, suggesting that they may mutually affect the chemokine binding and cellular responses of other splicing variants. Here, we performed an integrative analysis of the functional relations among CXCR3 splicing variants and their chemokine-dependent signaling using NanoBiT live cell protein interaction assays. The results indicated that the CXCR3 N-terminal region affected cell surface expression levels and ligand-dependent activation. CXCR3A was efficiently expressed in the plasma membrane and responded to I-TAC, IP-10, and MIG chemokines. By contrast, CXCR3B had low plasma membrane expression and mediated I-TAC-stimulated cellular responses. CXCR3Alt was rarely expressed on the cell surface and did not mediate any cell responses to the tested chemokines; however, CXCR3Alt negatively affected the plasma membrane expression of CXCR3A and CXCR3B and their chemokine-stimulated cellular responses. Jurkat cells express endogenous CXCR3, and exogenous CXCR3A expression enhanced chemotactic activity in response to I-TAC, IP-10, and MIG. By contrast, exogenous expression of CXCR3B and CXCR3Alt eliminated or reduced the CXCR3A-induced chemotactic activity. The PF-4 chemokine did not activate any CXCR3-mediated cellular responses. NanoBiT technology are useful to integrative studies of CXCR3-mediated cell signaling, and expand our knowledge of the cellular responses mediated by molecular interactions among the splicing variants, including cell surface expression, ligand-dependent receptor activation, and chemotaxis.
Effect of reactant mixing on fine particle production in a tubular flow reactor (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of reactant mixing on fine particle production in a tubular flow reactorToivo T. Kodas, Sheldon K. Friedlander, and Sotiris E. PratsinisCite this: Ind. Eng. Chem. Res. 1987, 26, 10, 1999–2007Publication Date (Print):October 1, 1987Publication History Published online1 May 2002Published inissue 1 October 1987https://pubs.acs.org/doi/10.1021/ie00070a011https://doi.org/10.1021/ie00070a011research-articleACS PublicationsRequest reuse permissionsArticle Views138Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fatigue Crack Growth Curve for Austenitic Stainless Steels in BWR Environment (2000)

Fatigue crack growth data obtained in the simulated BWR water environment were analyzed to establish a formula for reference fatigue crack growth rate (FCGR) of austenitic stainless steels in BWR water. The effects of material, mechanical and environmental factors were taken into the reference curve, which was expressed as: da/dN=8.17×10−12s˙Tr0.5s˙ΔK3.0/1−R2.121≦ΔK≦50 MPam where da/dN is fatigue crack growth rate in m/cycle, Tr is load rising time in seconds, ΔK is range (double amplitude) of K–value in MPam, and R is stress ratio. Tr=1 s if Tr&lt;1 s, and Tr=1000 s if Tr cannot be defined. ΔK=Kmax−Kmin if R≧0.ΔK=Kmax if R&lt;0.R=Kmin/Kmax. The proposed formula provides conservative FCGR at low stress ratio. Although only a few data show higher FCGR than that by proposed formula at high R, these data are located in a wide scatter range of FCGR and are regarded to be invalid. The proposed formula is going to be introduced in the Japanese Plant Operation and Maintenance Standard.
Engineered second-order nonlinearity in silicon nitride (2022)

The lack of a bulk second-order nonlinearity (\c{hi}(2)) in silicon nitride (Si3N4) keeps this low-loss, CMOS-compatible platform from key active functions such as Pockels electro-optic (EO) modulation and efficient second harmonic generation (SHG). We demonstrate a successful induction of \c{hi}(2) in Si3N4 through electrical poling with an externally-applied field to align the Si-N bonds. This alignment breaks the centrosymmetry of Si3N4, and enables the bulk \c{hi}(2). The sample is heated to over 500°C to facilitate the poling. The comparison between the EO responses of poled and non-poled Si3N4, measured using a Si3N4 micro-ring modulator, shows at least a 25X enhancement in the r33 EO component. The maximum \c{hi}(2) we obtain through poling is 0.24pm/V. We observe a remarkable improvement in the speed of the measured EO responses from 3GHz to 15GHz (3dB bandwidth) after the poling, which confirms the \c{hi}(2) nature of the EO response induced by poling. This work paves the way for high-speed active functions on the Si3N4 platform.
Retrieval of Images Captured by Car Cameras Using Its Front and Side Views and GPS Data (2007)

Recently, cars are equipped with a lot of sensors for safety driving. We have been trying to store the driving-scene video with such sensor data and to detect the change of scenery of streets. Detection results can be used for building historical database of town scenery, automatic landmark updating of maps, and so forth. In order to compare images to detect changes, image retrieval taken at nearly identical locations is required as the first step. Since Global Positioning System (GPS) data essentially contain some noises, we cannot rely only on GPS data for our image retrieval. Therefore, we have developed an image retrieval algorithm employing edge-histogram-based image features in conjunction with hierarchical search. By using edge histograms projected onto the vertical and horizontal axes, the retrieval has been made robust to image variation due to weather change, clouds, obstacles, and so on. In addition, matching cost has been made small by limiting the matching candidates employing the hierarchical search. Experimental results have demonstrated that the mean retrieval accuracy has been improved from 65% to 76% for the front-view images and from 34% to 53% for the side-view images.
Efficacy and Complications of Intravitreal Rituximab Injection for Treating Primary Vitreoretinal Lymphoma (2012)

The results of this trial support IVR as one element of combined modality therapy for treating PVRL patients without CNS involvement, particularly for those who respond poorly and have side effects with IVM. (http://www.umin.ac.jp/ctr/ number, UMIN000005604).
Textual Similarity with a Bag-of-Embedded-Words Model (2013)

While words in documents are generally treated as discrete entities, they can be embedded in a Euclidean space which reflects an a priori notion of similarity between them. In such a case, a text document can be viewed as a bag-of-embedded-words (BoEW): a set of real-valued vectors. We propose a novel document representation based on such continuous word embeddings. It consists in non-linearly mapping the word-embeddings in a higher-dimensional space and in aggregating them into a document-level representation. We report retrieval experiments in the case where the word-embeddings are computed from standard topic models showing significant improvements with respect to the original topic models.
ChemInform Abstract: Intramolecular Oxidative‐Cycloaddition of Dihydropyrazolones. (1987)

Abstract The dihydropyrazolones (I) react with lead tetraacetate, yielding the tricyclic compounds (III) by intramolecular Diels‐Alder reaction of the intermediates (II).
Antenna Design for Portable Computers (2007)

A summary is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
CdSe Layers of Below Critical Thickness in ZnSe Matrix: Intrinsic Morphology and Defect Formation (1998)

Three main stages of the intrinsic morphology transformation of MBE grown CdSe fractional monolayers in ZnSe with increase in their nominal thickness w in the 0.1-3.0 monolayer range were found using both structural and optical characterization techniques. Emergence of the extended (15-30 nm) CdSe-enriched quantum-dot-like pseudomorphic islands at w > 0.7 monolayer with the density increasing up to 2.5 x 10 10 cm-2 at w = 2.8 monolayer is clearly displayed in the optical properties of CdSe fractional monolayer nanostructures. The below critical thickness CdSe fractional monolayers having extremely high quantum efficiency can be very perspective as an active region of ZnSe-based blue-green lasers.
A case study in open source innovation: developing the Tidepool Platform for interoperability in type 1 diabetes management (2015)

The authors believe that the Tidepool Platform can solve two current problems in the T1D device landscape: 1) limited access to T1D device data and 2) poor interoperability of data from different devices. If proven effective, Tidepool's open source, cloud model for health data interoperability is applicable to other healthcare use cases.
Modeling And Estimation Of Massive Mimo Channel Non-Reciprocity: Sparsity-Aided Approach (2018)

Publication in the conference proceedings of EUSIPCO, Kos island, Greece, 2017
Multiscale and Multifield Multiphysics of High Current Pulse Static Contact With Rough Surfaces (2013)

We are presenting a multi-field and multiscale theory leading to derivations of physical properties from surface topography and bulk material properties for the interface between two rough surfaces in contact activated by mechanical load and high current pulses. At the macro-scale our proposed model involves multi-field coupling of conduction and induction currents with heat conduction induced by Joule heating. The structural mechanics of the conducting materials are also considered. At the meso-scale and micro-scale the associated model contains an asperity based comprehensive model that leads to homogenized macro scale properties for the interface boundary. The mechanical pressure and the repulsion effect from electric current through the micro-contacts are accounted for as well. Numerical analysis results illustrate the dependence of the derived properties on the surface characteristics, external load and the electric current. Finally, the entire framework is applied to an actual conductor configuration of hollow cylinders under compression and a high current pulse to demonstrate the feasibility of the entire approach.
Near-infrared sensitive small molecule organic photovoltaic cells based on chloroaluminum phthalocyanine (2007)

The use of chloroaluminum phthalocyanine (ClAlPc) as a donor and C60 as an acceptor in planar double heterojunction organic photovoltaic cells with response extending into the near infrared is demonstrated. X-ray diffraction indicates that under the conditions used in this study ClAlPc grows as an amorphous film. Although the absorption and film morphology show no dependence on growth rate, device performance is optimized at a growth rate of 0.5Å∕s, producing cells whose best performance gives an open circuit voltage of 0.68±0.01V, a responsivity of 0.062±0.007A∕W, a fill factor of 0.50±0.04, and a power conversion efficiency of 2.1±0.1% under simulated AM1.5G, 1 sun intensity illumination. This cell also displays low dark current under reverse bias, 2.4×10−8A∕cm2 at −1V.
Primary Frequency Control of Wind-solar-storage Power Station Considering Discrete Control Nonlinearity (2023)

Abstract With the gradual advancement of dual-carbon goals, the wind-solar-storage power station has become the mainstream trend in constructing new energy stations due to their wind energy and luminous complementary characteristics. However, the current research on primary frequency control of new energy stations is still focused on a single-machine strategy. The communication delay and control period caused by long control links are not considered. It is difficult to describe the influence of the difference in dynamic characteristics of wind-solar-storage power on primary frequency control performance. Therefore, this paper takes the multi-layer control link wind-solar-storage power station as the research object, establishes the nonlinear control model considering the influence of control delay and control period, and puts forward the wind-solar-storage power plant primary frequency control method, which is suitable for participating in the frequency control of power grid.
Sliced Cramer Synaptic Consolidation for Preserving Deeply Learned Representations (2020)

Deep neural networks suffer from the inability to preserve the learned data representation (i.e., catastrophic forgetting) in domains where the input data distribution is non-stationary, and it changes during training. Various selective synaptic\nplasticity approaches have been recently proposed to preserve network parameters, which are crucial for previously learned tasks while learning new tasks.\nWe explore such selective synaptic plasticity approaches through a unifying lens\nof memory replay and show the close relationship between methods like Elastic\nWeight Consolidation (EWC) and Memory-Aware-Synapses (MAS). We then propose a fundamentally different class of preservation methods that aim at preserving the distribution of the network’s output at an arbitrary layer for previous tasks\nwhile learning a new one. We propose the sliced Cramer distance as a suitable ´\nchoice for such preservation and evaluate our Sliced Cramer Preservation (SCP) ´\nalgorithm through extensive empirical investigations on various network architectures in both supervised and unsupervised learning settings. We show that SCP\nconsistently utilizes the learning capacity of the network better than online-EWC\nand MAS methods on various incremental learning tasks.
MOCVD-grown blue-green laser diode (1995)

Operation of the first blue-green laser diode grown by metal organic chemical vapour deposition (MOCVD) has been demonstrated at 77 K under pulsed current injection. The observed stimulated emission is at a wavelength of 473 nm, with threshold current ranging from 90 to 180 mA (0.9 – 1.8 kA/cm2), and threshold voltage of ~13.0 V. The emission also shows a strong transverse electric polarisation. The laser consists of a ZnCdSe single quantum-well, ZnSe optical guiding layers, and ZnMgSSe/ZnSSe dual-stacked cladding layers grown on a (100) n-GaAs substrate.
Compact Fiber Based 2.05 µm All-PM CPA System at 1 MHz and 1 MW Peak Power (2015)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text H. Hoogland and R. Holzwarth, "Compact Fiber Based 2.05 µm All-PM CPA System at 1 MHz and 1 MW Peak Power," in Advanced Solid State Lasers, OSA Technical Digest (online) (Optica Publishing Group, 2015), paper AW4A.9. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Enhanced snake-based segmentation of vocal folds (2005)

We present a system to segment the medial edges of the vocal folds from stroboscopic video. The system has two components. The first learns a color transformation that optimally discriminates, according to the Fisher linear criterion, between the trachea and vocal folds. Using this transformation, it is able to make a coarse segmentation of vocal fold boundaries. The second component uses an active contour formulation recently developed for the Insight Toolkit to refine detected contours. Rather than tune the internal energy of our active contours to bias for specific shapes, we optimize image energy so as to highlight boundaries of interest. This transformation of image energy simplifies the contour extraction process and suppresses noisy artifacts, which may confound standard implementations. We evaluate our system on stroboscopic video of sustained phonation. Our evaluation compares points on automatically extracted contours with manually supplied points at perceived vocal fold edges. Mean deviations for points located on the minor axes of the vocal folds averaged 2.2 pixels across all subjects, with a standard deviation of 3.6.
Preclinical Molecular Imaging of the Translocator Protein (TSPO) in a Metastases Model Based on Breast Cancer Xenografts Propagated in the Murine Brain (2012)

Previous studies have demonstrated the feasibility of translocator protein (TSPO) imaging to visualize and quantify human breast adenocarcinoma (MDA-MB-231) cells in vivo using a TSPO-targeted near-infrared (NIR) probe (NIR-conPK11195). This study aimed to extend the use of the TSPO-targeted probe to a more biologically relevant and clinically important tumor microenvironment as well as to assess our ability to longitudinally detect the presence and progression of breast cancer cells in the brain. The in vivo biodistribution and accumulation of NIR-conPK11195 and free (unconjugated) NIR dye were quantitatively evaluated in intracranial MDA-MB-231-bearing mice and non-tumor-bearing control mice longitudinally once a week from two to five weeks post-inoculation. The in vivo time-activity curves illustrate distinct clearance profiles for NIR-conPK11195 and free NIR dye, resulting in preferential accumulation of the TSPO-targeted probe in the intracranial tumor bearing hemisphere (TBH) with significant tumor contrast over normal muscle tissue (p
A dynamic pole-phase modulation induction machine model (2015)

Pole-phase modulation can provide performance benefits in highly dynamic applications through the electronic control of induction machine pole count. An applicable dynamic model is developed, and verified using finite element analysis. The proposed model can describe machines with an arbitrary number of electrical inputs and pole count configurations. The available degrees of freedom in polyphase vector space decomposition are used to develop decoupled energy conversion subspaces for each available pole count, allowing conventional control techniques to be directly applied. Simulation results for a smooth 2-pole/6-pole transition using field-oriented control techniques are provided.
An efficient low-complexity approach to color trapping (2007)

CMYK color separation is a technique commonly used in printing to reproduce mutli-color images. However, the color planes are generally not perfectly aligned with respect to each other when they are rendered by the imaging stations. This phenomenon, called color plane mis-registration, causes gap and halo artifacts. Trapping algorithms aim to reduce these artifacts by scanning through an image, determining the edges susceptible to mis-registration errors, and moving the edge boundaries of the lighter colorants underneath the edge boundaries of the darker colorants. In this paper, we propose a low-complexity approach to automatic color trapping which hides the effects of small color plane mis-registrations without negatively affecting the overall quality of the printed image.
Synthesis and properties of some novel high birefringence phenylacetylene liquid crystal materials with lateral substituents (2001)

Abstract We have synthesized and investigated new 3-ring phenylacetylene liquid crystals with high birefringence values (Δn) to improve the nematic temperature range while retaining a high optical anisotropy. In the case of modifying the terminal ring, the introduction of branched alkoxy chains, fluorine or methyl groups shifted the nematic phase to lower temperatures. In order to minimize the influence of the substituent on Δn, the incorporation of lateral methyl groups was chosen as the most profitable method for obtaining wide and low temperature nematic phases. With these results in mind, we studied the effect of the position of the methyl group on the physical properties. The most effective methyl position for improving the nematic temperature range was on the central ring. From the standpoint of obtaining high Δn values and low viscosity, the central ring was also the best position.
Odd–Even Effects in Charge Transport across n-Alkanethiolate-Based SAMs (2014)

This paper compares rates of charge transport across self-assembled monolayers (SAMs) of n-alkanethiolates having odd and even numbers of carbon atoms (nodd and neven) using junctions with the structure M(TS)/SAM//Ga2O3/EGaIn (M = Au or Ag). Measurements of current density, J(V), across SAMs of n-alkanethiolates on Au(TS) and Ag(TS) demonstrated a statistically significant odd-even effect on Au(TS), but not on Ag(TS), that could be detected using this technique. Statistical analysis showed the values of tunneling current density across SAMs of n-alkanethiolates on Au(TS) with nodd and neven belonging to two separate sets, and while there is a significant difference between the values of injection current density, J0, for these two series (log|J0Au,even| = 4.0 ± 0.3 and log|J0Au,odd| = 4.5 ± 0.3), the values of tunneling decay constant, β, for nodd and neven alkyl chains are indistinguishable (βAu,even = 0.73 ± 0.02 Å(-1), and βAu,odd= 0.74 ± 0.02 Å(-1)). A comparison of electrical characteristics across junctions of n-alkanethiolate SAMs on gold and silver electrodes yields indistinguishable values of β and J0 and indicates that a change that substantially alters the tilt angle of the alkyl chain (and, therefore, the thickness of the SAM) has no influence on the injection current density across SAMs of n-alkanethiolates.
Observation ofB0→D¯0K+K−and Evidence forBs0→D¯0K+K− (2012)

The first observation of the decay B0→D¯(0)K(+)K(-) is reported from an analysis of 0.62 fb(-1) of pp collision data collected with the LHCb detector. Its branching fraction is measured relative to that of the topologically similar decay B(0)→D ¯(0)π(+)π(-) to be (B(B(0)→D¯(0)K(+)K(-))/B(B(0)→D¯(0)π(+)π(-))=0.056±0.011±0.007,where the first uncertainty is statistical and the second is systematic. The significance of the signal is 5.8σ. Evidence, with 3.8σ significance, for B(s)(0)→D¯(0)K(+)K(-) decays is also presented. The relative branching fraction is measured to be B(B(s)(0)→D¯(0)K(+)K(-))/B(B(0)→D¯(0)K(+)K(-))=0.90±0.27±0.20. These channels are of interest to study the mechanisms behind hadronic B decays, and open new possibilities for CP violation analyses with larger data sets.