gebhart/patrepeval huggingface dataset:
COVID-19 and hematopoietic stem cell transplantation and immune effector cell therapy: a US cancer center experience (2021)

The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), identified in late 2019 as the causative agent of COVID-19, was declared a pandemic by the World Health Organization on 11 March 2020. Widespread community transmission in the United States triggered a nationwide shutdown, raising major challenges for administration of hematopoietic stem cell transplant (HSCT) and chimeric antigen receptor (CAR)-T cell therapies, leading many centers to delay or cancel operations. We sought to assess the impact of the COVID-19 pandemic on operations and clinical outcomes for HSCT and CAR-T cellular therapies at the Dana-Farber Cancer Institute by reviewing administration and outcomes in 127 cell therapy patients treated during the initial COVID-19 surge: 62 adult allogeneic HSCT (allo-HSCT), 38 autologous HSCT (auto-HSCT), and 27 CAR-T patients. Outcomes were compared with 66 allo-HSCT, 43 auto-HSCT, and 33 CAR-T patients treated prior to the pandemic. A second control cohort was evaluated for HSCT groups to reflect seasonal variation in infections. Although there were changes in donor selection and screening as well as cryopreservation patterns of donor products, no differences were observed across groups in 100-day overall survival, progression-free survival, rates of non-COVID-19 infections, including hospital length of stay, neutrophil engraftment, graft failure, acute graft-versus-host disease in allo-HSCT patients, or cytokine release syndrome and neurotoxicity in CAR-T patients. No HSCT patients contracted COVID-19 between days 0 and 100. One CAR-T patient contracted COVID-19 at day +51 and died of the disease. Altogether, our data indicate that cellular therapies can be safely administered throughout the ongoing COVID-19 pandemic with appropriate safeguards.
Measurement of the χ b (3P) mass and of the relative rate of χ b1(1P) and χ b2(1P) production (2014)

The production of b mesons in proton-proton collisions is studied using a data sample collected by the LHCb detector, at centre-of-mass energies of s = 7 and 8 TeV and corresponding to an integrated luminosity of 3.0 fb -1 . The b mesons are identified through their decays to (1S) and (2S) using photons that converted to e + e -pairs in the detector. The relative prompt production rate of b1 (1P ) and b2 (1P ) mesons is measured as a function of the (1S) transverse momentum in the b rapidity range 2.0 < y < 4.5. A precise measurement of the b (3P ) mass is also performed. Assuming a mass splitting between the b1 (3P ) and the b2 (3P ) states of 10.5 MeV/c 2 , the measured mass of the b1 (3P ) meson is m( b1 (3P )) = 10515.7 +2.2 -3.9 (stat) +1.5 -2.1 (syst) MeV/c 2 .
RELIABILITY AND VALIDITY OF THE FRAIL ELDERLY FUNCTIONAL ASSESSMENT QUESTIONNAIRE (1995)

Measuring functional activity for elderly at very low functional levels remains a challenge because many functional instruments have not been standardized in a frail elderly population. The Frail Elderly Functional Assessment questionnaire (FEFA) is a 19-item, interviewer-administered questionnaire designed to assess function in frail elderly at a very low activity level. The purpose of this study was to determine the reliability and validity of this instrument in a frail elderly population. Two groups of subjects over 65 yr old were selected to test the reliability and validity of this questionnaire. Test-retest reliability was determined by correlating the responses of 29 homebound (including nursing home-bound) subjects who answered the questionnaire on two occasions 2 wk apart. To assess the validity of the FEFA, the questionnaire was administered to 23 frail, homebound (including nursing home-bound) elderly subjects who had a Mini-Mental State Examination score of > or = 18. Validity was determined by correlating patient responses to direct observations by the investigators of tasks addressed in the questionnaire. Correlation was also determined against the Katz's Activity of Daily Living index, Lawton's Instrumental Activity of Daily Living index, and the Barthel index. The reliability coefficient was 0.82. Correlation between the FEFA questionnaire and direct observation of questionnaire task performance was 0.90. Construct validity against the Katz's Activity of Daily Living, Lawton's Instrumental Activity of Daily Living, and the Barthel index showed correlations of 0.86, 0.67 and 0.91, respectively. Initial data indicate that the FEFA is a valid and reliable instrument that may be useful in assessing function in frail elderly people.
An unusual peptide conformation may precipitate amyloid formation in Alzheimer's disease: application of solid-state NMR to the determination of protein secondary structure (1991)

The formation of insoluble proteinaceous deposits is characteristic of many diseases which are collectively known as amyloidosis. There is very little molecular-level structural information available regarding the amyloid deposits due to the fact that the constituent proteins are insoluble and noncrystalline. Therefore, traditional protein structure determination methods such as solution NMR and X-ray crystallography are not applicable. We report herein the application of the solid-state NMR technique rotational resonance (R2) to the accurate measurement of carbon-to-carbon distances in the amyloid formed from a synthetic fragment (H2N-LeuMetValGlyGlyValValIleAla-CO2H) of the amyloid-forming protein of Alzheimer's disease (AD). This sequence has been implicated in the initiation of amyloid formation. Two distances measured by R2 indicate that an unusual structure, probably involving a cis amide bond, is present in the aggregated peptide amyloid. This structure is incompatible with the accepted models of fibril structure. A relationship between this structure and the stability of the amyloid is proposed.
[Paper] Time-to-Contact in Scattering Media Environments based on Statistical Priors (2017)

In this paper, we propose a novel method for estimating time-to-contact (TTC) in scattering media environments, such as fog and water. For an object moving towards another object, time-to-contact measures the time remaining until collision. Therefore, it is especially useful for safe automated vehicle navigation in the 3D space. Time-to-contact estimation is advantageous because it does not require camera calibration, freeing it from calibration errors. Earlier studies commonly used geometric features of objects such as edges and points to estimate time-to-contact. In scattering media environments, the degradation of image intensity caused by light scattering makes it diﬃcult to obtain clear geometric features. Thus, in this paper we propose a method for estimating time-to-contact in scattering media by using the photometric features in the image instead. We use statistical priors to obtain depth information from the captured image intensity and compute the time-to-contact from estimated transmission of the media.
Muscle synergies during incremental rowing VO2max test of collegiate rowers and untrained subjects. (2016)

The findings of this study showed that muscle synergies were robust during aerobic-dominant activity for collegiate rowers and untrained subjects. Rowers and coaches could utilize the findings by emphasizing on muscle coordination training, which may enhance the rowing economy.
2-Furoylglycine as a Candidate Biomarker of Coffee Consumption (2015)

Specific and sensitive food biomarkers are necessary to support dietary intake assessment and link nutritional habits to potential impact on human health. A multistep nutritional intervention study was conducted to suggest novel biomarkers for coffee consumption. (1)H NMR metabolic profiling combined with multivariate data analysis resolved 2-furoylglycine (2-FG) as a novel putative biomarker for coffee consumption. We relatively quantified 2-FG in the urine of coffee drinkers and investigated its origin, metabolism, and excretion kinetics. When searching for its potential precursors, we found different furan derivatives in coffee products, which are known to get metabolized to 2-FG. Maximal urinary excretion of 2-FG occurred 2 h after consumption (p = 0.0002) and returned to baseline after 24 h (p = 0.74). The biomarker was not excreted after consumption of coffee substitutes such as tea and chicory coffee and might therefore be a promising acute biomarker for the detection of coffee consumption in human urine.
The Genes of the Murine T Cell Receptor (1985)

T cells recognize antigen in a way fundamentally different from B cells. It has been known now for a decade (1–3) that the T cell receptor sees the antigen, not alone, but in association the major histocompatibility complex (MHC, H-2 in the mouse). As a general rule cytotoxic T (Tc) cells recognize antigen in association with Class I MHC molecules and helper T (Th) cells do so with Class II structures (4,5).
Pancreatic graft survival after arterial thrombosis in simultaneous renal‐pancreatic transplantation (1993)

Vascular thrombosis following pancreas transplantation is one of the main causes of early graft loss. Successful thrombectomy after pancreatic graft thrombosis has not been reported yet. A patient with arterial graft thrombosis in whom the graft survived after thrombectomy is described. Different varieties of pancreatic graft thrombosis are discussed.
Neuronal Ubiquitinated Intranuclear Inclusions in Familial and Non-Familial Frontotemporal Dementia of the Motor Neuron Disease Type Associated with Amyotrophic Lateral Sclerosis (2004)

Ubiquitinated cytoplasmic inclusions (Ub-CIs) in superficial frontal cortex and dentate gyrus neurons are the hallmark of frontotemporal degeneration of the motor neuron disease-type (FTD-MND-type). To date, 2 reports have described intranuclear ubiquitinated inclusions (Ub-INIs) in 9 cases of familial FTD-MND-type (without clinical or pathologic motor neuron disease, MND). In the current study we found an additional 11 cases with Ub-INIs. We have identified for the first time among these cases 2 with a negative family history and 3 that have concomitant amyotrophic lateral sclerosis (ALS). The results of the present study i) confirm a previous report of significantly lower average brain weight and longer duration in cases with Ub-INIs, ii) reveal significantly greater striatal neuronal loss and gliosis in cases with intranuclear inclusions, and iii) demonstrate that intranuclear inclusions correlate with cytoplasmic inclusions and dystrophic neurites in frontal cortex and striatum but not in dentate gyrus. In addition, the current study confirms that Ub-INIs are found in familial FTD-MND-type, but also extends the presence of Ub-INIs to familial FTD-MND (with concomitant ALS), and probably also to non-familial FTD-MND-type.
Hydrophobic Vancomycin Derivatives with Improved ADME Properties: Discovery of Telavancin (TD‐6424). (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
ChemInform Abstract: A Facile Two‐Carbon Ring Expansion Process Based on the 2‐Cyano‐1‐vinylcycloalkanol System. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
In‐Situ Incorporation of Amoxicillin in PVA/PVAc‐co‐PMMA Particles during Suspension Polymerizations (2011)

Abstract Embolization is a radiological technique that consists in occluding a blood vessel intentionally with an embolic agent (particle). A suspension polymerization process was developed to allow for production of embolic particles with core‐shell morphology. This technology was modified to allow for the in‐situ incorporation of antibiotics (amoxicillin) in PVA/PVAc‐co‐PMMA core‐shell particles. The incorporation of amoxicillin led to modification of some of the final polymer properties, including the particle morphology, the molecular weight distribution and the characteristic transition temperatures of the polymer material. The final polymer properties depended on the antibiotic concentration and on how the drug was added into the polymerization medium.
Remarks on "Analysis of one popular group signature scheme" in Asiacrypt 2006 (2009)

At Asiacrypt 2006, Cao presented a putative framing 'attack' against the ACJT group signature scheme by Ateniese et al. This paper shows that the attack framework considered by Cao is invalid. As we clearly illustrate, there is no security weakness in the ACJT group signature scheme as long as all the detailed specifications of the original paper are being followed.
An Effective Hydrajet-Fracturing Implementation Using Coiled Tubing and Annular Stimulation Fluid Delivery (2005)

Abstract The use of coiled tubing (CT) in fracturing was uncommon until a few years ago. Its applications have usually been limited to small jobs, and in reality, CT stimulation treatments have often been limited to acid placement treatments. With the inception of hydrajet fracturing technology, the use of CT has become more popular. Historically, CT fracturing methods were limited to placement of small fractures in the formation, and in some acidizing situations, near-wellbore damage-bypass methods. CT technology has progressed until now it is used to place large fractures, some reaching over 600-ft half-lengths. Obviously, in most formations, such fracture sizes would not be possible with fluid delivery originating from the CT alone, so the use of the annulus to deliver the primary fracturing fluid becomes vital. This paper discusses the knowledge gained from recent field applications that have used this new annular path hydrajet-fracturing technology. Unique features of this technology are presented. Added benefits, such as the ability to deliver large proppant volumes, will be a focal point of this paper. Case studies involving placement of multi-fracture treatments in three wells treated with this procedure will be discussed. Production improvements experienced in these wells will also be presented.
Gynogenetic Activation of Porcine Oocytes (2014)

The possibility of fertilization without male contribution to the embryonic genome was investigated in pig oocytes. Mature oocytes were co-incubated with sperm, and in an attempt to prevent the incorporation of the sperm head into the ooplasm, the actin polymerization inhibitor cytochalasin B was added to the fertilization medium. We found that perturbing actin filament integrity did not affect the pattern of the sperm-induced Ca(2+) signal or the process of cortical granule exocytosis, and it did not alter the percentage of activated oocytes compared to the control (oocytes fertilized in the absence of the inhibitor). However, over 20% of the cytochalasin B-treated oocytes formed only a single pronucleus after fertilization, indicating that the inhibitor blocked sperm head incorporation at least in some oocytes. In most cases, cytochalasin B also prevented the integration of the male chromosomes into the embryonic genome as determined by the absence of the SRY gene in the embryonic blastomeres or by the frequency of embryos showing green fluorescence after sperm from a GFP-transgenic boar was used for fertilization. Finally, the percentage of embryos that developed beyond the four-cell stage and the total number of nuclei in the resultant blastocysts were higher when oocytes reconstructed by nuclear transfer were activated by fertilization in the presence of cytochalasin B compared to the control group, where activation was induced by electroporation. These results suggest that fertilization in the presence of cytochalasin B can induce oocyte activation while it also prevents integration of the male genome into the embryo. This method has the potential to be used as an alternative to inducing embryonic development after nuclear transfer.
Test-circuit-based extraction of inter- and intra-chip MOSFET-performance variations for analog-design reliability (2002)

We propose an efficient, test-circuit-based method to determine not only CMOS-device-parameter variations but to simultaneously separate intra-chip from inter-chip variations. The method is demonstrated by using a differential-amplifier stage with feedback coupling as the test-circuit and the drift-diffusion MOSFET model HiSIM for the circuit simulation. The result shows that the proposed test circuit, when constructed only with n-MOSFETs or p-MOSFETs, enables one to separate gate length and channel doping variations as well as their inter- and intra-chip magnitudes in a direct way.
Privacy and sharing information on spherical and large flat displays (2011)

It is important for users to understand the fundamental tradeoff between sharing information and preserving privacy in collaboration. The more information is shared about one's actions, the less privacy is preserved. Sharing information may, in fact, counter-intuitively result in increased social stress in some cases. Maintaining privacy while allowing for the sharing of information is an important consideration for successful collaboration and we believe display form factor matters for this tradeoff. New form factors such as spherical displays support privacy naturally, by limiting a user's view to at most one hemisphere. In this video we show how different types of interactive large display form factor can provide a balance between privacy and the sharing of information in a cooperative game.
New strategies for the medical treatment of prostate cancer (2005)

Androgen is a major growth factor in the normal prostate and determines the overall number of prostate cells. Metastatic prostate cancer, while initially responsive to androgen ablation, eventually becomes hormone-refractory and resistant to many treatments. Unfortunately, there are very few agents in the preclinical stage with a seemingly promising future for hormone-refractory prostate cancer (HRPC) that are actually taken through the complete drug development process, including US Food and Drug Administration approval. Many novel strategies under investigation for treating HRPC target metastatic prostate cancer cells that are neither androgen-dependent nor in the proliferative state. Examples of therapies that target this so-called "Achilles' heel" of HRPC include immune therapy, gene therapy, angiogenesis inhibition, and activation of programmed cell death. Unique properties of HRPC allow for the development of novel treatments that target prostate-specific antigen (PSA), human glandular kallikrein-2, or prostate-specific membrane antigen. An inactive prodrug with a thapsigargin analogue, a sesquiterpene lactone from the plant Thapsia garganica, is currently under investigation specifically for the targeted therapy of HRPC. Preclinical data suggest the PSA-targeting abilities of this novel therapy are associated with a nearly complete cessation of tumour growth with minimal toxicity.
Biodefense-Driven Murine Model of Pneumonic Melioidosis (2002)

A whole-body mouse model of pneumonic melioidosis was established for future evaluation of biodefense vaccine candidates. The aerosol 50% lethal doses of Burkholderia pseudomallei strain 1026b for BALB/c and C57BL/6 mice and the times to death, dissemination in organs, and tissue loads after exposure of the mice to low- and high-dose aerosols are reported. In addition, rpsL mutant backgrounds were attenuated in this acute model of disease.
Special issue on 'Interaction of electromagnetic waves with low-temperature plasmas' (2013)

Plasma Sources Science and Technologyis pleased to announce a special issue focusing on the interaction of electromagnetic waves with low-temperature plasmas, to be published in the summer of 2014.
Solid‐phase Synthesis and Cellular Localization of a C‐ and/or N‐terminal Labelled Peptide (1996)

We report the solid-phase synthesis by the Fmoc strategy of a peptide containing a cysteamide group at its C-terminus. This peptide was subjected to further modifications including the linkage of fluorophores, namely lucifer yellow and coumarin respectively, at the C- and/or N-terminals. After incubation with living cultured cells these two probes were localized and it is concluded that the post-synthesis modifications can strongly modify the localization of the peptide.
Systems genetics uncovers microbe-lipid-host connections in the murine gut (2021)

Abstract The molecular bases of how host genetic variation impact gut microbiome remain largely unknown. Here, we used a genetically diverse mouse population and systems genetics strategies to identify interactions between molecular phenotypes, including microbial functions, intestinal transcripts and cecal lipids that influence microbe-host dynamics. Quantitative trait loci (QTL) analysis identified genomic regions associated with variations in bacterial taxa, bacterial functions, including motility, sporulation and lipopolysaccharide production, and levels of bacterial- and host-derived lipids. We found overlapping QTL for the abundance of Akkermansia muciniphila and cecal levels of ornithine lipids (OL). Follow-up studies revealed that A. muciniphila is a major source of these lipids in the gut, provided evidence that OL have immunomodulatory effects and identified intestinal transcripts co-regulated with these traits. Collectively, these results suggest that OL are key players in A. muciniphila- host interactions and support the role of host genetics as a determinant of responses to gut microbes.
A High-Speed Power-Line Communication System with Band-Limited OQAM Based Multi-Carrier Transmission (2009)

As a method to realize a high-speed communication in the home network, the power-line communication (PLC) technique is known. A problem of PLC is that leakage radiation interferes with existing systems. When OFDM is used in a PLC system, the leakage radiation is not sufficiently reduced, even if the subcarriers corresponding to the frequency-band of the existing system are never used, because the signal is not strictly band-limited. To solve this problem, each subcarrier must be band-limited. In this paper, we apply the OQAM based multi-carrier transmission (OQAM-MCT) to a high-speed PLC system, where each subcarrier is individually band-limited. We also propose a pilot-symbol sequence suitable for frequency offset estimation, symbol-timing detection and channel estimation in the OQAM-MCT system. In this method, the pilot signal-sequence consists of a repeated series of the same data symbol. With this method, the pilot sequence approximately becomes equivalent to OFDM sequence and therefore existing pilot-assisted methods for OFDM are also applicable to OQAM-MCT system. Computer simulation results show that the OQAM-MCT system achieves both good transmission rate performance and low out-of-band radiation in PLC channels. It is also shown that the proposed pilot-sequence improves frequency offset estimation, symbol-timing detection and channel estimation performance as compared with the case of using pseudo-noise sequence.
Metal organic frameworks (MOF) as CO2 adsorbents (2014)

Absorption properties and their connection to the structure of new type of CO2 adsorbents underlain by Metal Organic Frameworks (MOF) are discussed. MOF are more efficient than water solutions of amines.