gebhart/patrepeval huggingface dataset:
Food and Market Waste–A Pathway to Sustainable Fuels and Waste Valorization (2019)

Food and market waste (FMW) is one of the most abundant unrecycled products which poses waste management issues and negative environmental impacts. Thermo-catalytic reforming (TCR) is a pyrolysis based technology which can convert a wide range of biomass wastes into energy vectors bio-oil, syngas, and char. This paper investigates the conversion potential of FMW into sustainable biofuels. The FMW was processed using a laboratory scale 2 kg/h TCR reactor. The process produced 7 wt % organic bio-oil, 53 wt % permanent gas, and 22 wt % char. The bio-oil higher heating value (HHV) was found to be 36.72 MJ/kg, comparable to biodiesel, and contained a low oxygen content (<5%) due to cracking of higher molecular weight organics. Naphthalene was detected to be the most abundant aromatic compound within the oil, with relative abundance of 12.95% measured by GC-MS. The total acid number of the oil (TAN) and viscosity were 11.7 mg KOH/g and 6.3 cSt, respectively. The gross calorific value of the produced biochar was 23.64 MJ/kg, while the permanent gas showed a higher heating value of approximately 17 MJ/Nm<sup>3</sup>. Methane (CH<sub>4</sub>) was found to be the largest fraction in the permanent gases reaching over 23%. This resulted either due to the partial methanation of biosyngas over the catalytically active FMW biochar or the hydrogenation of coke deposited on the biochar in the post reforming stage.
Inhomogeneity Localization in Scattering Media Based on an Optical Diffusion Model (2007)

A fast approach for detecting and localizing an inhomogeneity in a tissue-like scattering medium is presented. The probability of detection and sensitivity describe the capability of such a measurement system, providing information for instrument design.
Bimodal Regulation of Ceramidase by Interleukin-1β (1997)

Interleukin 1beta (IL-1beta) induces the hydrolysis of sphingomyelin (SM) to ceramide (Cer) in primary cultures of rat hepatocytes, and Cer has been proposed to play a role in the down-regulation of cytochrome P450 2C11 (CYP2C11) and induction of alpha1-acid glycoprotein (AGP) by this cytokine (Chen, J., Nikolova-Karakashian, M., Merrill, A. H. & Morgan, E. T. (1995) J. Biol. Chem. 270, 25233-25238). Nonetheless, some of the features of the down-regulation of CYP2C11 do not fit a simple model of Cer as a second messenger as follows: N-acetylsphinganine (C2-DHCer) is as potent as N-acetylsphingosine (C2-Cer) in suppression of CYP2C11; the IL-1beta concentration dependence for SM turnover is different from that for the increase in Cer; and the increase in Cer mass is not equivalent to the amount of SM hydrolyzed nor the time course of SM hydrolysis. In this article, we report that these discrepancies are due to activation of ceramidase by the low concentrations of IL-1beta ( approximately 2.5 ng/ml) that maximally down-regulate CYP2C11 expression, whereas higher IL-1beta concentrations (that induce AGP) do not activate ceramidase and allow Cer accumulation. This bimodal concentration dependence is demonstrated both by in vitro ceramidase assays and in intact hepatocytes using a fluorescence Cer analog, 6-((N-(7-nitrobenz-2-oxa-1, 3-diazol-4-yl)amino)-Cer (NBD-Cer), and following release of the NBD-fatty acid. IL-1beta increases both acid and neutral ceramidase activities, which appear to be regulated by tyrosine phosphorylation because pretreatment of hepatocytes with sodium vanadate increases (and 25 microM genistein reduces) the basal and IL-1beta-stimulated ceramidase activities. Since these findings suggested that sphingosine (and, possibly, subsequent metabolites) is the primary mediator of the down-regulation of CYP2C11 by IL-1beta, the effects of exogenous sphingosine and C2-Cer on expression of this gene were compared. Sphingosine was more potent than C2-Cer in down-regulation of CYP2C11 when added alone or with fumonisin B1 to block acylation of the exogenous sphingosine. Furthermore, the suppression of CYP2C11 by C2-Cer (and C2-DHCer) is probably mediated by free sphingoid bases, rather than the short chain Cer directly, because both are hydrolyzed by hepatocytes and increase cellular levels of sphingosine and sphinganine. From these observations we conclude that sphingosine, possibly via sphingosine 1-phosphate, is a mediator of the regulation of CYP2C11 by IL-1beta in rat hepatocytes and that ceramidase activation provides a "switch" that determines which sphingolipids are elevated by this cytokine to produce multiple intracellular responses.
Crystallographic Studies of Organosilicon Porphyrins:  Stereoelectronic Effects of Axial Groups on the Nonplanarity of the Porphyrin Ring (1998)

Organosilicon tetraphenylporphyrins (Si(TPP)R2) with alkyl, alkenyl, alkynyl, and aryl groups at the axial positions (R) were synthesized. X-ray crystallographic studies demonstrated that the porphyrin ligands are virtually “planar” in Si(TPP)(CH2CH2CH3)2 and Si(TPP)(CHCH2)2, nearly planar but slightly “waved” in Si(TPP)(CH2Si(CH3)3)2 and Si(TPP)(C⋮CC6H5)2, and moderately “ruffled” in Si(TPP)(C6H5)2.
Nanotechnology-Based Photodynamic Therapy for Neovascular Disease Using a Supramolecular Nanocarrier Loaded with a Dendritic Photosensitizer (2005)

Photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD) was evaluated using a supramolecular nanomedical device, that is, a novel dendritic photosensitizer (DP) encapsulated by a polymeric micelle formulation. The characteristic dendritic structure of the DP prevents aggregation of its core sensitizer, thereby inducing a highly effective photochemical reaction. With its highly selective accumulation on choroidal neovascularization (CNV) lesions, this treatment resulted in a remarkably efficacious CNV occlusion with minimal unfavorable phototoxicity.
Nanocrystalline Oligo(ethylene sulfide)-b-poly(ethylene glycol) Micelles: Structure and Stability (2018)

Micelle formation generally relies on hydrophobic or electrostatic interactions between distinct regions of amphiphilic molecules. In this work, a different mechanism is considered in which nanocrystalline domains are formed from short ethylene sulfide oligomers at the core of the micelles, leading to exceptionally stable, uniform micellar structures. The structure and thermodynamic properties of the resulting micelles are examined through a combination of experiments, theory, and simulations. It is found that in oligo(ethylene sulfide)-b-poly(ethylene glycol) amphiphiles as few as three ethylene sulfide monomers are sufficient to form a highly crystalline core, surrounded by a water-soluble ethylene glycol corona of arbitrary size. Sulfur–sulfur interactions induce formation of rhombohedral lattice crystalline regions, which exhibit well-defined intramolecular and intermolecular order. An atomistic model is used to determine the free energy of the micelles; the critical micelle concentration (CMC) is found to be extremely small, on the order of 10–8 mol/L. The size distribution of these micelles is nearly monodisperse. The crystalline core also includes amorphous regions that could serve as hosts for other molecules. Taken together, these properties serve to underscore that controlled crystallization provides a useful and underexploited mechanism for assembly of ultrastable micelles for applications in a variety of settings, including drug delivery and immunology.
Long-Term Prognosis of Patients Diagnosed With Brugada Syndrome (2010)

In the largest series of Brugada syndrome patients thus far, event rates in asymptomatic patients were low. Inducibility of ventricular tachyarrhythmia and family history of SCD were not predictors of cardiac events.
Novel Inhibitors of Potassium Ion Channels on Human T Lymphocytes (1995)

The in vitro biological characterization of a series of 4-(alkylamino)-1,4-dihydroquinolines is reported. These compounds are novel inhibitors of voltage-activated n-type potassium ion (K+) channels in human T lymphocytes. This series, identified from random screening, was found to inhibit [125I]charybdotoxin binding to n-type K+ channels with IC50 values ranging from 10(-6) to 10(-8) M. These analogs also inhibit whole cell n-type K+ currents with IC50 values from 10(-5) to 10(-7) M. The preparation of a series of new 4-(alkylamino)-1,4-dihydroquinolines is described. Structure-activity relationships are discussed. Naphthyl analog 7c, the best compound prepared, exhibited > 100-fold selectivity for inhibition of [125I]charybdotoxin binding to n-type K+ channels compared with inhibition of [3H]dofetilide binding to cardiac K+ channels. These compounds represent a potent and selective series of n-type K+ channel inhibitors that have the potential for further development as anti-inflammatory agents.
Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-0687) and 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-5-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-1430) (2016)

Optimization of the potency and pharmacokinetic profile of 2,3,4-trisubstituted quinoline, 4, led to the discovery of two potent, selective, and orally bioavailable PI3Kδ inhibitors, 6a (AM-0687) and 7 (AM-1430). On the basis of their improved profile, these analogs were selected for in vivo pharmacodynamic (PD) and efficacy experiments in animal models of inflammation. The in vivo PD studies, which were carried out in a mouse pAKT inhibition animal model, confirmed the observed potency of 6a and 7 in biochemical and cellular assays. Efficacy experiments in a keyhole limpet hemocyanin model in rats demonstrated that administration of either 6a or 7 resulted in a strong dose-dependent reduction of IgG and IgM specific antibodies. The excellent in vitro and in vivo profiles of these analogs make them suitable for further development.
Factory-Calibrated Continuous Glucose Sensors: The Science Behind the Technology (2017)

The use of commercially available continuous glucose monitors for diabetes management requires sensor calibrations, which until recently are exclusively performed by the patient. A new development is the implementation of factory calibration for subcutaneous glucose sensors, which eliminates the need for user calibrations and the associated blood glucose tests. Factory calibration means that the calibration process is part of the sensor manufacturing process and performed under controlled laboratory conditions. The ability to move from a user calibration to factory calibration is based on several technical requirements related to sensor stability and the robustness of the sensor manufacturing process. The main advantages of factory calibration over the conventional user calibration are: (a) more convenience for the user, since no more fingersticks are required for calibration and (b) elimination of use errors related to the execution of the calibration process, which can lead to sensor inaccuracies. The FreeStyle Libre<sup>™</sup> and FreeStyle Libre Pro<sup>™</sup> flash continuous glucose monitoring systems are the first commercially available sensor systems using factory-calibrated sensors. For these sensor systems, no user calibrations are required throughout the sensor wear duration.
Peptide-amidating Enzymes Are Expressed in the Stellate Epithelial Cells of the Thymic Medulla (1998)

C-terminal amidation is a post-translational processing step necessary to convey biological activity to a large number of regulatory peptides. In this study we have demonstrated that the peptidyl-glycine alpha-amidating monooxygenase enzyme complex (PAM) responsible for this activity is located in the medullary stellate epithelial cells of the thymus and in cultured epithelial cells bearing a medullary phenotype, using Northern blot, immunocytochemistry, in situ hybridization, and enzyme assays. Immunocytochemical localization revealed a granular pattern in the cytoplasm of the stellate cells, which were also positive for cytokeratins and a B-lymphocyte-associated antigen. The presence of PAM activity in medium conditioned by thymic epithelial cell lines suggests that PAM is a secreted product of these cells. Among the four epithelial cell lines examined, there was a direct correlation between PAM activity and content of oxytocin, an amidated peptide. Taken together, these data provide convincing evidence that thymic epithelial cells have the capacity to generate amidated peptides that may influence T-cell differentiation and suggest that the amidating enzymes could play an important role in the regulation of thymic physiology.
Micro Cu Bump Interconnection on 3D Chip Stacking Technology (2003)

The three-dimensional (3D) chip stacking LSI technology under development at the Association of Super-Advanced Electronic Technologies (ASET) is a new packaging technology to realize high-density and high-speed transmission, and superfine flip-chip bonding technologies in 20-µm-pitch microbumps on Cu through-via (TV) are substantial technologies. As for advanced bonding technology, Cu bump bonding (CBB) utilizing Sn alloy is a simple process to connect Cu TVs directly without the formation of bumps on the device back surface, and the influence of the intermetallic compound (IMC) on the minute interconnection focusing on the bondability and reliability was verified, and the following results were obtained. The IMC state formed at the bonding interface depended on bonding temperature, and was confirmed as multilayered Cu6Sn5 and Cu3Sn at 240°C, and single-layered Cu3Sn at 350°C. The IMC state is the governing factor of bondabilities of Cu bump interconnection in a 20-µm-pitch. The electroresistance value of the Cu bump interconnection was approximately 0.45 Ω, and no significant difference was confirmed under each condition. Young's modulus values of IMC (Cu6Sn5:112.6 GPa and Cu3Sn:132.7 GPa) were obtained by the nano-indentation test. The Sn-Ag layer as bonding material should be reduced to Cu-Sn IMC, and a low-rigid resin was preferable in terms of interconnection reliability based on the results of finite element method (FEM) analysis. Finally, the vertical interconnections utilizing CBB were formed, and the increase in electrical resistance by stacking one TV chip was approximately 0.03 Ω. Therefore, sufficient electrical vertical interconnection of Cu TV in a 20-µm-pitch was performed.
Dynamic Analysis of Executables to Detect and Characterize Malware (2018)

Malware detection and remediation is an on-going task for computer security and IT professionals. Here, we examine the use of neural algorithms to detect malware using the system calls generated by executables-alleviating attempts at obfuscation as the behavior is monitored. We examine several deep learning techniques, and liquid state machines baselined against a random forest. The experiments examine the effects of concept drift to understand how well the algorithms generalize to novel malware samples by testing them on data that was collected after the training data. The results suggest that each of the examined machine learning algorithms is a viable solution to detect malware-achieving between 90% and 95% class-averaged accuracy (CAA). In real-world scenarios, the performance evaluation on an operational network may not match the performance achieved in training. Namely, the CAA may be about the same, but the values for precision and recall over the malware can change significantly. We structure experiments to highlight these caveats and offer insights into expected performance in operational environments. In addition, we use the induced models to better understand what differentiates malware samples from goodware, which can further be used as a forensics tool to provide directions for investigation and remediation.
Asymmetric Lewis acid catalysis directed by octahedral rhodium centrochirality (2014)

A rhodium-based asymmetric catalyst is introduced which derives its optical activity from octahedral centrochirality. Besides providing the exclusive source of chirality, the rhodium center serves as a Lewis acid by activating 2-acyl imidazoles through two point binding and enabling a very effective asymmetric induction mediated by the propeller-like <i>C</i><sub>2</sub>-symmetrical ligand sphere. Applications to asymmetric Michael additions (electrophile activation) as well as asymmetric α-aminations (nucleophile activation) are disclosed, for which the rhodium catalyst is found to be overall superior to its iridium congener. Due to its straightforward proline-mediated synthesis, high catalytic activity (catalyst loadings down to 0.1 mol%), and tolerance towards moisture and air, this novel class of chiral-at-rhodium catalysts will likely to become of widespread use as chiral Lewis acid catalysts for a large variety of asymmetric transformations.
Flexible operation of photovoltaic electrodialysis (PV-ED) low-cost community-scale desalination systems (2019)

Although brackish groundwater desalination is a promising solution to water scarcity in rural India, powering desalination systems in remote locations where grid power is not reliable remains an issue due to the high upfront cost of solar panels and batteries. This paper focuses on photovoltaic electrodialysis (PV-ED) desalination and proposes novel, flexible operation modes to integrate more efficiently the time-dependent solar power with the ED load, and replace energy storage in batteries by water storage in tanks. By first defining an irradiance-dependent desalination schedule, and further on extending the system flexibility to adjust in real-time the system power consumption, a better matching between the energy supply and demand is proposed that directly converts solar energy into water and potentially eliminates battery needs. Coupled with a system-level optimization of the desalination and power modules, operating with a flexible schedule leads 42% capital cost reduction compared to PV-ED systems conventionally designed. Additional cost reductions are anticipated from the fully-flexible operation with close to 90% of the solar energy directly used by the system, which is twice as much as the level achieved by binary on/off control in the optimal configuration.
Synthesis of Chiral β-oxy-γ-lactones on Sugar Templates: Influence of the Substituents Around C-6 on the Conformation of the Pyranose Ring (1994)

Abstract The synthesis of β-oxy-γ-lactones, starting from the epoxy ketoses 1b and 2b and using the enolates of acetate units, is described. The effect of the substituents around C-6 on the pyranose conformation is also discussed.
Influence of the Carbon–Carbon Bond Order and Silver Loading on the Formation of Surface Species and Gas Phase Oxidation Products in Absence and Presence of NOx over Silver-Alumina Catalysts (2012)

The influence of carbon–carbon bond order, here systematically represented by prototypical C2H6, C2H4, and C2H2, on the formation of oxidation products and surface species in the absence and presence of NO has been studied for silver-alumina catalysts with different silver loadings (2 and 6 wt %). The catalysts were prepared with a sol–gel method including freeze-drying, which results in small silver species uniformly distributed throughout the alumina matrix. The performance of the catalysts was investigated by temperature programmed extinction-ignition experiments using a continuous gas flow reactor. The evolution of surface species during reactant step-response experiments was studied in situ by diffuse reflection Fourier transform infrared spectroscopy. The results show that activation for oxidation generally proceeds more easily with increasing bond order of the hydrocarbon. For example, C2H2 shows the highest conversion at low temperatures. Furthermore, the use of hydrocarbons with high bond order, that is, C2H2, as reductant for lean NOx reduction results not only in the highest peak activity but also in considerable high activity in a wide temperature range mainly thanks to high activity at low temperature. With increasing silver loading, the oxidation reactions are favored such that both the hydrocarbon and the NO activation occur at lower temperatures. Several types of adsorbates, for example, carbonate, acetate, formate, enolic and isocyanate/cyanide surface species, are present on the catalyst during reaction. Generally the nature of the surface species and likely also the surface processes are more influenced by the carbon–carbon bond order than the silver loading. This needs to be considered when designing catalysts for emission control systems. Especially for applications using homogeneous fuels with short hydrocarbons, this may provide opportunities to tailor the catalyst functionality for the needs at hand.
Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB2 Receptor Expression and Ligand Engagement in Human Cells (2018)

Chemical tools and methods that report on G protein-coupled receptor (GPCR) expression levels and receptor occupancy by small molecules are highly desirable. We report the development of LEI121 as a photoreactive probe to study the type 2 cannabinoid receptor (CB<sub>2</sub>R), a promising GPCR to treat tissue injury and inflammatory diseases. LEI121 is the first CB<sub>2</sub>R-selective bifunctional probe that covalently captures CB<sub>2</sub>R upon photoactivation. An incorporated alkyne serves as ligation handle for the introduction of reporter groups. LEI121 enables target engagement studies and visualization of endogenously expressed CB<sub>2</sub>R in HL-60 as well as primary human immune cells using flow cytometry. Our findings show that strategically functionalized probes allow monitoring of endogenous GPCR expression and engagement in human cells using tandem photoclick chemistry and hold promise as biomarkers in translational drug discovery.
ChemInform Abstract: Progress Toward an Antibody Glycosidase. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Partial Update Adaptive Transmit Beamforming with Limited Feedback (2006)

This work proposes a new partial update filtering technique tailored for adaptive transmit beamforming with low feedback rate. A signal dependent selection rule is derived that singles out one component of the beamforming vector to be updated. This provides an efficient way to perform the update, which escalates the performance with the number of available feedback bits without increasing the computational complexity. An operation count for the proposed algorithm and existing solutions is provided. Simulations show that the proposed scheme outperforms the tracking capabilities of existing codebook solutions in low mobility scenarios, while having comparable bit error probability performance and a computational complexity reduction of 90%.
Dielectric properties of layered silicate‐reinforced natural and polyurethane rubber nanocomposites (2007)

Abstract Natural rubber (NR), polyurethane rubber (PUR), and NR/PUR‐based nanocomposites were prepared by adding a pristine synthetic layered silicate (LS; sodium fluorohectorite) in 10 parts per hundred parts rubber, following the latex compounding route. The dispersion of the LS latices in the composites was studied by means of X‐ray diffraction (XRD) and transmission electron microscopy (TEM). The morphology‐dependent dielectric properties of the produced nanocomposites were examined using broadband dielectric spectroscopy (BDS) at ambient temperature. Besides the glass/rubber transition of the polymer matrices, interfacial polarization (IP) is evident in the produced nanocomposites. The α‐relaxation, as well as the β‐mode, in the PUR‐containing nanocomposites proved to be less affected by the presence of LSs. The obtained experimental data suggest that the LS is more compatible with and thus better intercalated by the PUR than by the NR which was prevulcanized in this case. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007