gebhart/patrepeval huggingface dataset:
Chronological requirements of TDP-43 function in synaptic organization and locomotive control (2014)

Alterations in TDP-43 are commonly found in patients suffering from amyotrophic lateral sclerosis (ALS) and the genetic suppression of the conserved homologue in Drosophila (TBPH) provokes alterations in the functional organization of motoneuron synaptic terminals, resulting in locomotive defects and reduced life span. To gain more insight into this pathological process, it is of fundamental importance to establish when during the fly life cycle the lack of TBPH affects motoneuron activity and whether this is a reversible phenomenon. To achieve this, we conditionally expressed the endogenous protein in TBPH minus Drosophila neurons and found that TBPH is a short lived protein permanently required for Drosophila motility and synaptic assembly through the direct modulation of vesicular proteins, such as Syntaxin 1A, indicating that synaptic transmission defects are early pathological consequences of TBPH dysfunction in vivo. Importantly, TBPH late induction is able to recover synaptogenesis and locomotion in adult flies revealing an unexpected late-stage functional and structural neuronal plasticity. These observations suggest that late therapeutic approaches based on TDP-43 functionality may also be successful for the human pathology.
Soiling effect on photovoltaic modules performance: New experimental results (2016)

This paper presents new experimental results on the effect of soiling and its impact on the energy productivity of photovoltaic systems. Based on effective measurements, the soiling rate of photovoltaic modules has been determined and correlated with the rainfall and power generated for the same period. The experimental approach detailed in the paper aims at elaborating an efficient soiling measurement protocol for PV and CPV modules mounted on biaxial sun tracker, located in Rabat (Morocco) which is characterized by a Mediterranean climate with warm to hot dry summers and mild damp winters.
ChemInform Abstract: TOTAL SYNTHESIS OF THE C‐NUCLEOSIDE DL‐SHOWDOMYCIN BY A DIELS‐ALDER, RETROGRADE DIECKMANN STRATEGY (1981)

Abstract Die Synthese der racemischen Titelverbindung (X) ausgehend vom Diels‐Alder‐Addukt des 1,3‐Dicarboalkoxyallens (I) und Furan (II) über die aufgezeichneten Reaktionsstufen wird detailliert beschrieben.
Selective Separation of Lithium Chloride by Organogels Containing Strapped Calix[4]pyrroles (2021)

Reported herein are two functionalized crown ether strapped calix[4]pyrroles, <b>H1</b> and <b>H2</b>. As inferred from competitive salt binding experiments carried out in nitrobenzene-<i>d</i><sub>5</sub> and acetonitrile-<i>d</i><sub>3</sub>, these hosts capture LiCl selectively over four other test salts, <i>viz</i>. NaCl, KCl, MgCl<sub>2</sub>, and CaCl<sub>2</sub>. Support for the selectivity came from density functional theory (DFT) calculations carried out in a solvent continuum. These theoretical analyses revealed a higher innate affinity for LiCl in the case of <b>H1</b>, but a greater selectivity relative to NaCl in the case of <b>H2</b>, recapitulating that observed experimentally. Receptors <b>H1</b> and <b>H2</b> were outfitted with methacrylate handles and subject to copolymerization with acrylate monomers and cross-linkers to yield gels, <b>G1</b> and <b>G2</b>, respectively. These two gels were found to adsorb lithium chloride preferentially from an acetonitrile solution containing a mixture of LiCl, NaCl, KCl, MgCl<sub>2</sub>, and CaCl<sub>2</sub> and then release the lithium chloride in methanol. The gels could then be recycled for reuse in the selective adsorption of LiCl. As such, the present study highlights the use of solvent polarity switching to drive separations with potential applications in lithium purification and recycling.
Environmental control of Th17 differentiation (2009)

Abstract Th17 cells participate in the control of extracellular bacteria and fungi, but dysregulated Th17 cell activity can result in immunopathology. Thus, the generation and the activity of Th17 cells should be tightly regulated, and simultaneously it should be able to respond to the challenges presented by a changing environment. In this viewpoint, we discuss some of the mechanisms by which microbes, dietary components and environmental toxins influence the Th17 response.
A 142dB Dynamic Range CMOS Image Sensor with Multiple Exposure Time Signals (2005)

An ultra wide dynamic range image sensor with a linear response is presented. The proposed extremely short accumulation (ESA) signal readout technique enables the dynamic range of image sensor to be expanded up to 142dB. Including the ESA signals, total of 4 different accumulation time signals are read out in one frame based on burst readout mode. To achieve the high-speed readout required for the multiple exposure signals, column parallel A/D converters are integrated at the upper and lower sides of pixel array. The improved column parallel cyclic 12-b ADC with a built-in CDS circuit has the differential non-linearity of plusmn0.3LSB
Artificial Pancreas Goes Outpatient: A New Diabetes Ecosystem (2013)

The artificial pancreas (AP) offers an ideal solution to many patients with diabetes treated by insulin because it covers the triple aim of diabetes therapy: (i) close-to-normal mean glucose control in order to prevent long-term diabetes complications, (ii) maintenance of glucose levels in a safe range in order to avoid acute brain-debilitating glucose excursions, and (iii) minimal burden in disease management thanks to a discrete wearable system, including an insulin infuser, a glucose monitor, and a diabetes controller.
Kinetic Analysis of Current Enhanced Intermetallic Growth and Its Effect on Electromigration Reliability of Solder Joints (2006)

A kinetic analysis was formulated for electromigration induced intermetallics evolution of a Cu-Sn diffusion couple. Simulation of the time dependency of intermetallic growth is consistent with experimental data showing growth and accumulation of a high concentration of vacancies and formation of Kirkendall voids at the Cu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> Sn <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> side of the Cu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> Sn/Cu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> Sn <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> interface
Analog compressed sensing for RF propagation channel sounding (2012)

Massively broadband® RF channel sounding is severely constrained by the sampling rates required for analog to digital conversion. Analog compressed sensing (CS) techniques based on Xampling have demonstrated the ability to lower sampling rates far below the Nyquist rate. Here, we show attributes of the multipath channel sounding problem appear to be well suited to CS approaches for reducing measurement acquisition time while simultaneously estimating time delays, multipath amplitudes, and angles of arrival. This paper presents results of the fusion of CS with modern channel sounding. We show measured propagation data from 60 GHz field trials and note the channel sparsity in time and space. We then propose an architecture for the first massively broadband CS channel sounder based on the Xampling framework (which we call the Channel Sounding Xampler) to exploit the sparsity, and we use field measurements to explore tradeoffs between analog and digital signal processing to perform channel impulse response (CIR) parameter estimation in real time. We also offer conceptual approaches for the Channel Sounding Xampler designed to trade off analog and digital components with the goal of improving CIR acquisition at sub-THz frequencies.
Positive Urine Paliperidone Test Results in the Absence of Prescribed Medication (2017)

The urine of a 36-year-old man tested positive for paliperidone (9-hydroxyrisperidone). The patient denied having taken risperidone or paliperidone, 2 drugs that can cause positivity for paliperidone.

This patient was diagnosed with schizoaffective disorder and is currently prescribed antipsychotic and other mental health-related medications: clomipramine (25/75 mg) and clozapine (200 mg), both at bedtime. Urine specimens were collected to monitor medication adherence. Quantitative LC-MS/MS methods developed and validated in our laboratory were used to test for various antipsychotic drugs and related metabolites in urine. Laboratory results included clomipramine, 264 ng/mL; clozapine, 990 ng/mL; n -desmethylclozapine, 4178 g/L; and paliperidone, 12 ng/mL, by LC-MS/MS. Reporting cutoffs for these medications are 200 ng/mL, 25 ng/mL, 25 ng/mL, and 5 ng/mL, respectively. Sample validity testing results included specific gravity, 1.009; pH 5.3; and creatinine, 99.1 g/L, which are all acceptable within range.

n -Desmethylclozapine is a metabolite of clozapine, and its positive result matched with the prescription for clozapine. However, the paliperidone result could be from either the parent drug (such as Invega®) or as a metabolite of risperidone (Risperdal®) use. Neither of these drugs was listed as a current prescription for the patient. A technical replicate of the urine using the same LC-MS/MS method reconfirmed the …
Current principles of design for cemented and cementless knees (1991)

Twenty years of experience with modern total knee arthroplasty have shown certain designs of prosthesis to be extremely successful. Modifications have been made to earlier designs in an attempt to improve fixation and decrease the potential for excessive wear, but new problems sometimes develop. Based on this experience, certain principles become evident which should guide surgeon/designers in the development of the next generation of knee replacement implants.
Insights into the pathophisiology of cardiorenal syndrome type II in the rat (2013)

Background: Cardiorenal Syndrome Type II (CRSII) is kidney function deterioration in the presence of Chronic Heart Failure (CHF). The mechanisms leading to kidney damage in CHF are however still obscure.We studied the development of kidney injury in a model of right CHF (monocrotaline (MC) treated rats). Methods: 10 animals were treated with MC for 4 weeks until they developed HF. 11 were taken as control. The occurrence of HF wasdemonstrated by signs of congestion, hypertrophy and dilatation of the right ventricle, and by the determination of BNP. We measured pNGAL, pCreatinine (ELISA), kidney NGAL (RT-PCR), and pTNF, IL1, IL4, IL6, IL10 (Multiplex protein microarray). Kidney cell apoptosis was assessed by TUNEL. Results: MC treated rats showed higher BNP values (MC 4.71.2, C 1.50.5 pg/mL p<0.004), marked RV Hypetrophy and dilatation (RVMass/RVVolume MC 1.460.31 C 2.40.8 p<0.01), pleural and peritoneal effusions. TNF (MC 1325.37559.95 vs C 84.4664.50 pg/ml), IL1 (MC183.7151.61 vs C 78.3126.07 pg/ml), IL4 (MC 731.67154.83 vs C 316.6212.55 pg/ml), IL6 (MC 5314.9831632.98 vs C 1754.01188.85 pg/ml), IL10 (MC 2613.10934.04 vs C 847.70152.19 pg/ml) were all increased (p<0.05) as well as Creatinine (MC 0.950.4 vs C 0.570.4 pg/ml p<0.05). Both plasma (MC 0.560.28 vs C 0.250.16 ug/mL,p<0.02) and renal NGAL (MC 70.78.7 vs C 32.19.9 AU, p<0.001) were significantly increased and a higher number of kidney apoptotic cells was found (MC 69.31.6 vs C32.22.9 cells/mm 2 , p<0.04). Conclusion: CHF in the rat is accompanied by deterioration of kidney function (CRSII). A rise of creatinine and NGAL, an early biomarker of kidney damage, was detected. Kidney cells apoptosis triggered by circulating pro-inflammatory cytokines represent the final insult to the kidney due to the CHF-induced perturbation of neuro-endocrine and inflammatory milieu
High-gain inertial confinement fusion by volume ignition, avoiding the complexities of fusion detonation fronts of spark ignition (1995)

Summary form only given, as follows. The main approach to inertial confinement fusion (ICF) uses a high-temperature, low-density core and a high-density, low-temperature outer region of the laser(or ion beam-) compressed deuterium-tritium (D-T) fuel, in order to ignite a fusion detonation wave at the interface. This is an extremely delicate, unstable configuration which is very difficult to achieve, even with a carefully programmed time dependence of the deposition of the driver energy. This approach was devised in order to reach the high gains needed for low-efficiency lasers. Since 1978, several teams have developed an alternative scheme using volume ignition, where a natural and simple adiabatic compression, starting from a low initial temperature of 3 keV or less, is used. The high gains are obtained by self-heating due to the fusion reaction products plus self-absorption of Bremsstrahlung. Fortunately, a strong deviation from LTE occurs at ion temperatures above 100 keV, with much lower electron and even lower radiation temperatures. We report here how the gains calculated by different groups are relatively large, and despite detailed differences in the stopping power models, do not differ greatly.
Prognose der österreichischen Wirtschaft 2016 – 2017: Inlandsnachfrage trägt Konjunktur (2016)

Nach 0.9 % im Vorjahr sollte die österreichische Wirtschaft 2016 um 1.5 % zulegen, wobei die Steuerreform den privaten Konsum stützt. Für 2017 wird ebenfalls ein Wachstum von 1.5 % erwartet. Damit entspricht das heimische Wachstum wieder dem Euroraum-Durchschnitt. Aufgrund des starken Arbeitskräfteangebots klettert die Arbeitslosenquote auf 9.4 % bzw. 9.8 %.
Comparative study of the toxicity between three non-steroidal anti-inflammatory drugs and their UV/Na2S2O8 degradation products on Cyprinus carpio (2018)

The efficiency of advanced oxidation processes (AOPs) for disposing of non-steroidal anti-inflammatory drugs (NSAIDs) has been widely studied, but the environmental fates and effects of the NSAIDs and their degradation products (DPs) are poorly understood. In this study, the efficiency of ultraviolet light/Na<sub>2</sub>S<sub>2</sub>O<sub>8</sub> (UV/PS) in degrading three NSAIDs-diclofenac, naproxen, and ibuprofen-and the toxicity of their DPs on Cyprinus carpio (C. carpio) was investigated. Results showed that the three NSAIDs can be completely removed (removal rate > 99.9%) by UV/PS, while the mineralization rate of the NSAIDs was only 28%. When C. carpio were exposed to 0.1 μM NSAIDs, 10 μM persulfate (PS), and 0.1 μM DPs of the NSAIDs for 96 h, respectively, the toxicity effects are as the NSAID DPs > PS > NSAIDs. Research results into the time-dependent effect of NSAID DPs on C. carpio demonstrated that obvious toxicity effects were observed in the first 48 hours, and the toxicity effects strengthened over time. NSAID DPs may have more severe toxicity effects than NSAIDs on C. carpio; therefore, the operating conditions of UV/PS must be optimized to eliminate the ecotoxicity of DPs.
Field Results on MIMO Performance in UMB Systems (2008)

The paper presents MIMO field performance results observed using a ultra mobile broadband (UMB) testbed network. We evaluate metrics such as antenna correlations and channel condition number to characterize the MIMO channel. Results show that low condition numbers, which are beneficial to MIMO, are prevalent for a majority of the coverage area in our network. We demonstrate that the use of MIMO provides gains of the order of 20-40% over SIMO transmissions. These gains are made possible by the use of cross-polarized transmit antennas and advanced UMB features that allow dynamic MIMO vs. SIMO transmission selection based on channel conditions. These results are obtained in a truly mobile, wireless wide-area deployment, which makes them unique. Our results point to the viability and value of MIMO in future mobile wireless networks.
Interaction of synthetic D‐6‐deoxy‐myo‐inositol 1,4,5‐trisphosphate with the Ca2+‐releasing D‐myo‐inositol 1,4,5‐trisphosphate receptor, and the metabolic enzymes 5‐phosphatase and 3‐kinase (1991)

The ability of D-6-deoxy-myo-inositol 1,4,5-trisphosphate [6-deoxy-Ins(1,4,5)P3], a synthetic analogue of the second messenger D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3], to mobilise intracellular Ca2+ stores in permeabilised SH-SY5Y neuroblastoma cells was investigated. 6-Deoxy-Ins(1,4,5)P3 was a full agonist (EC50 = 6.4 microM), but was some 70-fold less potent than Ins (1,4,5)P3 (EC50 = 0.09 microM), indicating that the 6-hydroxyl group of Ins(1,4,5)P3 is important for receptor binding and stimulation of Ca2+ release, but is not an essential structural feature. 6-Deoxy-Ins(1,4,5)P3 was not a substrate for Ins (1,4,5)P3 5-phosphatase, but inhibited both the hydrolysis of 5-[32P]+ Ins (1,4,5)P3 (Ki 76 microM) and the phosphorylation of [3H]Ins(1,4,5)P3 (apparent Ki 5.7 microM). 6-Deoxy-Ins (1,4,5)P3 mobilized Ca2+ with different kinetics to Ins(1,4,5)P3, indicating that it is probably a substrate for Ins (1,4,5)P3 3-kinase.
Face related features in consumer electronic (CE) device environments (2005)

The smart usage of the scattered processing power of consumer-electronics-device networks permits analytical systems to be realized capable of generating semantically meaningful meta information. A combination of 'service units' such as face detection, face tracking, face recognition and face online learning provides the basic visual descriptors for advanced facial- and human-related feature analysis. Reuse of the available computational resources of individual Philips-Nexperia-chipset-based consumer electronics devices - sufficient to enable individual service units to perform - in combination with descriptor databases facilitate the establishment of a powerful analytical system built on consumer electronics device networks.
Finding partial orders from unordered 0-1 data (2005)

In applications such as paleontology and medical genetics the 0-1 data has an underlying unknown order (the ages of the fossil sites, the locations of markers in the genome). The order might be total or partial: for example, two sites in different parts of the globe might be ecologically incomparable, or the ordering of certain markers might be different in different subgroups of the data. We consider the following problem. Given a table over a set of 0-1 variables, find a partial order for the rows minimizing a score function and being as specific as possible. The score function can be, e.g., the number of changes from 1 to 0 in a column (for paleontology) or the likelihood of the marker sequence (for genomic data). Our solution for this task first constructs small totally ordered fragments of the partial order, then finds good orientations for the fragments, and finally uses a simple and efficient heuristic method for finding a partial order that corresponds well with the collection of fragments. We describe the method, discuss its properties, and give empirical results on paleontological data demonstrating the usefulness of the method. In the application the use of the method highlighted some previously unknown properties of the data and pointed out probable errors in the data.
End user software engineering (2010)

End users create software whenever they create, for instance, interactive web pages, games, educational simulations, or spreadsheets. Researchers are working to bring the benefits of rigorous software engineering methodologies to these end users to try to make their software more reliable. Unfortunately, errors are pervasive in end-user software, and the resulting impact is sometimes enormous. This special interest group meeting will bring together the community of researchers who are addressing this topic with the companies that are creating and using end-user programming tools.
The Carbonic Anhydrase Inhibitor Dorzolamide Stimulates the Differentiation of Human Meibomian Gland Epithelial Cells (2020)

Our results support our hypothesis and demonstrate that the CAI dorzolamide does exert a direct influence on the proliferation and differentiation of iHMGECs. However, this effect is elicited only by a high, and not a therapeutic, amount of dorzolamide. <b>Abbreviations:</b> AKT: phosphoinositide 3-kinase-protein kinase B; BPE: bovine pituitary extract; CAD: cationic amphiphilic drug; DED: dry eye disease; DMEM/F12: 1:1 mixture of Dulbecco's modified Eagle's medium and Ham's F-12; EGF: epidermal growth factor; FBS: fetal bovine serum; iHMGECs: immortalized human meibomian gland epithelial cells; KSFM: keratinocyte serum-free medium; LAMP-1: lysosomal-associated membrane protein 1; LC3A: light chain 3A; MGD: meibomian gland dysfunction; SREBP-1: sterol regulatory element-binding protein 1.
Optical 8PSK Transmitter using Tandem IQ Modulators with Binary Driving Electrical Signals (2011)

We propose and demonstrate an optical 8-ary phase-shift keying (8PSK) transmitter using tandem in-phase/quadrature (IQ) modulators. A 30-Gb/s 8PSK is successfully generated through cascading a rectangular quadrature phase-shift keying (QPSK) and a square QPSK.
Reported Use of IV-Tissue Plasminogen Activator (IV-TPA) for Acute Ischemic Stroke (AIS) Worldwide: A Systematic Review (IN7-2.001) (2013)

OBJECTIVE: To report the global use of IV-TPA for AIS by country, income group, country-level health expenditure per capita, and quality of research studies.
Family-wide Analysis of the Inhibition of Arf Guanine Nucleotide Exchange Factors with Small Molecules: Evidence of Unique Inhibitory Profiles (2017)

Arf GTPases and their guanine nucleotide exchange factors (ArfGEFs) are major regulators of membrane traffic and organelle structure in cells. They are associated with a variety of diseases and are thus attractive therapeutic targets for inhibition by small molecules. Several inhibitors of unrelated chemical structures have been discovered, which have shown their potential in dissecting molecular pathways and blocking disease-related functions. However, their specificity across the ArfGEF family has remained elusive. Importantly, inhibitory responses in the context of membranes, which are critical determinants of Arf and ArfGEF cellular functions, have not been investigated. Here, we compare the efficiency and specificity of four structurally distinct ArfGEF inhibitors, Brefeldin A, SecinH3, M-COPA, and NAV-2729, toward six ArfGEFs (human ARNO, EFA6, BIG1, and BRAG2 and Legionella and Rickettsia RalF). Inhibition was assessed by fluorescence kinetics using pure proteins, and its modulation by membranes was determined with lipidated GTPases in the presence of liposomes. Our analysis shows that despite the intra-ArfGEF family resemblance, each inhibitor has a specific inhibitory profile. Notably, M-COPA is a potent pan-ArfGEF inhibitor, and NAV-2729 inhibits all GEFs, the strongest effects being against BRAG2 and Arf1. Furthermore, the presence of the membrane-binding domain in Legionella RalF reveals a strong inhibitory effect of BFA that is not measured on its GEF domain alone. This study demonstrates the value of family-wide assays with incorporation of membranes, and it should enable accurate dissection of Arf pathways by these inhibitors to best guide their use and development as therapeutic agents.
Learning to score the figure skating sports videos (2018)

This paper targets at learning to score the figure skating sports videos. To address this task, we propose a deep architecture that includes two complementary components, i.e., Self-Attentive LSTM and Multi-scale Convolutional Skip LSTM. These two components can efficiently learn the local and global sequential information in each video. Furthermore, we present a large-scale figure skating sports video dataset -- FisV dataset. This dataset includes 500 figure skating videos with the average length of 2 minutes and 50 seconds. Each video is annotated by two scores of nine different referees, i.e., Total Element Score(TES) and Total Program Component Score (PCS). Our proposed model is validated on FisV and MIT-skate datasets. The experimental results show the effectiveness of our models in learning to score the figure skating videos.