gebhart/patrepeval huggingface dataset:
End Groups of Functionalized Siloxane Oligomers Direct Block-Copolymeric or Liquid-Crystalline Self-Assembly Behavior (2016)

Monodisperse oligodimethylsiloxanes end-functionalized with the hydrogen-bonding ureidopyrimidinone (UPy) motif undergo phase separation between their aromatic end groups and dimethylsiloxane midblocks to form ordered nanostructures with domain spacings of <5 nm. The self-assembly behavior of these well-defined oligomers resembles that of high degree of polymerization (N)-high block interaction parameter (χ) linear diblock copolymers despite their small size. Specifically, the phase morphology varies from lamellar to hexagonal to body-centered cubic with increasing asymmetry in molecular volume fraction. Mixing molecules with different molecular weights to give dispersity >1.13 results in disorder, showing importance of molecular monodispersity for ultrasmall ordered phase separation. In contrast, oligodimethylsiloxanes end-functionalized with an O-benzylated UPy derivative self-assemble into lamellar nanostructures regardless of volume fraction because of the strong preference of the end groups to aggregate in a planar geometry. Thus, these molecules display more classically liquid-crystalline self-assembly behavior where the lamellar bilayer thickness is determined by the siloxane midblock. Here the lamellar nanostructure is tolerant to molecular polydispersity. We show the importance of end groups in high χ-low N block molecules, where block-copolymer-like self-assembly in our UPy-functionalized oligodimethylsiloxanes relies upon the dominance of phase separation effects over directional end group aggregation.
Phage Libraries — A New Route to Clinically Useful Antibodies (1996)

Antibodies can bind with high affinity and specificity to molecules of virtually any shape and to antigens ranging from small organic compounds to large proteins. These characteristics have led to the widespread use of antibodies as laboratory reagents, in diagnostic tests, and for therapeutic purposes. The immune system produces antibodies by a process of natural selection. In this article we describe how the strategy of natural selection can be used in bacteria to produce antibodies with novel characteristics and binding properties. This technology is opening up new diagnostic and therapeutic applications of antibodies.Antibody Production in VivoIn vivo, antigen-driven . . .
[Clinical and genetic studies of a three-member familial isolated pituitary adenoma with homogeneous prolactinomas]. (2020)

Most pituitary adenomas are sporadic, but 3-5% can occur in a family and hereditary context. This is the case of multiple endocrine neoplasia type 1 (MEN1), Carney complex (CNC) and familial isolated pituitary adenomas (FIPA). FIPA is an infrequent condition that occurs in a family context, not associated with MEN type1 or CNC. FIPA kindred can be homogeneous (all adenomas affected in the family having the same tumor phenotype) or heterogeneous (different tumor phenotypes in the affected members). We describe a Congolese family in which two sisters and a cousin were diagnosed with a prolactinoma (homogenous FIPA) at the ages of 29, 32 and 40 years, respectively. The patients presented with macroadenomas at the time of diagnosis, non-invasive tumors and good biological response to cabergoline treatment (maximum dose of 1.5 mg/weekly). Of these two sisters, one went through a pregnancy without complications. Because no MEN1 and CNC clinical and biochemical features were detected during the 12-year follow-up, these genes were not investigated. The genetic analysis of the aryl hydrocarbon receptor interacting protein (AIP) was normal. As nearly 80% of patients with FIPA do not have a mutation in the AIP gene, future studies in these families are required to identify other affected genes involved in their physiopathology.
Hall current sensor IC with integrated Co-based alloy thin film magnetic concentrator (2013)

This work deals with a cobalt-based alloy thin film magnetic concentrator (MC) which is fully integrated on a Hall sensor integrated circuit (IC) developed in the 0.35 µm Bipolar CMOS DMOS (BCD) technology on 8” silicon wafer. An amorphous magnetic film with a thickness of 1µm, coercitive field Hc<10A/m and saturation magnetization (µ0MS) of 0.45T has been obtained with a sputtering process. The Hall sensor IC has shown sensitivity to magnetic field at room temperature of 240V/AT without concentrator and 2550V/AT with concentrator, gaining a factor of 10.5. A current sensor demonstrator has been realized showing linear response in the range -50 to 50A.
Cryotherapy as Adjunct Treatment for Fibromyalgia (2022)

Common symptoms associated with fibromyalgia are chronic widespread pain, fatigue, sleep disturbances, depression, and cognitive dysfunction. Cryotherapy, which is commonly used in sports medicine, is used to alleviate pain and inflammation by exposing the body to cold temperatures maintained at -110°C and below. Recent evidence has shown that cryotherapy has a potential beneficial role in treating fibromyalgia. This review summarizes the unknown etiology of fibromyalgia, first-line treatment options for fibromyalgia, and how cryotherapy can be effective in reducing fibromyalgia symptoms. Cryotherapy might be useful adjunctive treatment but further research is still needed with larger sample sizes.
Effect of Polyethylene Glycol on Properties and Drug Encapsulation–Release Performance of Biodegradable/Cytocompatible Agarose–Polyethylene Glycol–Polycaprolactone Amphiphilic Co-Network Gels (2016)

We synthesized agarose-polycaprolactone (Agr-PCL) bicomponent and Agr-polyethylene glycol-PCL (Agr-PEG-PCL) tricomponent amphiphilic co-network (APCN) gels by the sequential nucleophilic substitution reaction between amine-functionalized Agr and activated halide terminated PCL or PCL-b-PEG-b-PCL copolymer for the sustained and localized delivery of hydrophilic and hydrophobic drugs. The biodegradability of the APCNs was confirmed using lipase and by hydrolytic degradation. These APCN gels displayed good cytocompatibility and blood compatibility. Importantly, these APCN gels exhibited remarkably high drug loading capacity coupled with sustained and triggered release of both hydrophilic and hydrophobic drugs. PEG in the APCNs lowered the degree of phase separation and enhanced the mechanical property of the APCN gels. The drug loading capacity and the release kinetics were also strongly influenced by the presence of PEG, the nature of release medium, and the nature of the drug. Particularly, PEG in the APCN gels significantly enhanced the 5-fluorouracil loading capacity and lowered its release rate and burst release. Release kinetics of highly water-soluble gemcitabine hydrochloride and hydrophobic prednisolone acetate depended on the extent of water swelling of the APCN gels. Cytocompatibility/blood compatibility and pH and enzyme-triggered degradation together with sustained release of drugs show great promise for the use of these APCN gels in localized drug delivery and tissue engineering applications.
Circulating Methylated DNA (2004)

Early detection of cancer would facilitate better management of patients, because survival is greatly affected by stage of presentation. Circulating nucleic acids represent a biomarker that might be used in the early detection of cancer. In addition, such biomarkers could potentially be used to follow the progression of patients with cancer. DNA methylation of the promoter region CpG islands of genes represents one such nucleic acid-based marker, and possesses some advantages over other approaches. These include the stability of DNA as a molecule, the ability to detect such changes using simple polymerase chain reaction-based approaches, and the potential for methylated DNA to be preferentially present in nucleosomes in plasma or serum. These factors are presented and their impact on the detection of methylated DNA circulating in the bloodstream is demonstrated.
Supplementary Figure 1 from Preclinical Characterization of AMG 330, a CD3/CD33-Bispecific T-Cell–Engaging Antibody with Potential for Treatment of Acute Myelogenous Leukemia (2023)

&lt;p&gt;PDF file - 83KB, Supplementary Figure S1. Characteristics of purified AMG 330.&lt;/p&gt;
Spatially variant regularization improves diffuse optical tomography (1999)

Diffuse tomography with near-infrared light has biomedical application for imaging hemoglobin, water, lipids, cytochromes, or exogenous contrast agents and is being investigated for breast cancer diagnosis. A Newton-Raphson inversion algorithm is used for image reconstruction of tissue optical absorption and transport scattering coefficients from frequency-domain measurements of modulated phase shift and light intensity. A variant of Tikhonov regularization is examined in which radial variation is allowed in the value of the regularization parameter. This method minimizes high-frequency noise in the reconstructed image near the source-detector locations and can produce constant image resolution and contrast across the image field.
Interactions Between Two Phase-Locked Loop Synchronized Grid Converters (2021)

Grid converters synchronized by phase-locked loops (PLLs) could suffer from stability problems, especially being connected to a weak grid or high penetration of converters. The existing literature assesses the stability of the paralleled PLL-synchronized converters at the same point of common coupling (PCC) using identical control and system parameters. However, in an actual grid, the parameters of grid converters are normally different due to different manufacturers. In this regard, this article aims to study the stability indices and margins of two PLL-synchronized converters with different parameters, particularly with different PLL bandwidths and power injections. The main purpose of this article is to provide a general design guidelines of PLL bandwidths of two converters (can be extended to two wind/solar farms) for stable operation in practical grids. The state-space model of the PLL-synchronized converter based on the component connection method is developed and eigenvalue-based analysis is used to investigate the interactions between the two converters. Moreover, the stability borders of two PLL-synchronized converters using different PLL bandwidths and power setpoints are studies. Monte Carlo simulations and experimental results are provided to validate the effectiveness of the developed model and theoretical analysis.
Rotational resonance with multiple-pulse scaling in solid-state nuclear magnetic resonance (1994)

Multiple-pulse techniques are applied to rotational resonance experiments in solid-state nuclear magnetic resonance. The usual rotational resonance condition is satisfied when an integral multiple of the magic-angle spinning speed equals the difference in isotropic chemical shifts of the two members of a homonuclear spin-1/2 pair. We show that sequences of rapid periodic radio-frequency pulses scale and rotate both the Zeeman and dipole–dipole Hamiltonians, leading to a modification of the resonance condition and to the introduction of new, single- and double-quantum, rotational resonances. Experimental results are presented which demonstrate these effects in the spectra of doubly 13C-labeled solids.
Fault-Tolerant Associative Memories Based on <formula formulatype="inline"><tex Notation="TeX">$c$</tex></formula>-Partite Graphs (2015)

Associative memories allow the retrieval of previously stored messages given a part of their content. In this paper, we are interested in associative memories based on c-partite graphs that were recently introduced. These memories are almost optimal in terms of the amount of storage they require (efficiency) and allow retrieving messages with low complexity. We propose a generic implementation model for the retrieval algorithm that can be readily mapped to an integrated circuit and study the retrieval performance when hardware components are affected by faults. We show using analytical and simulation results that these associative memories can be made resilient to circuit faults with a minor modification of the retrieval algorithm. In one example, the memory retains 88% of its efficiency when 1% of the storage cells are faulty, or 98% when 0.1% of the binary outputs of the retrieval algorithm are faulty. When considering storage faults, the fault tolerance exhibited by the proposed associative memory can be comparable to using a capacity-achieving error correction code for protecting the stored information.
Efficient Amination of Activated and Non‐Activated C(sp3)−H Bonds with a Simple Iron–Phenanthroline Catalyst (2020)

Abstract A readily available catalyst consisting of iron dichloride in combination with 1,10‐phenanthroline catalyzes the ring‐closing C−H amination of N ‐benzoyloxyurea to form imidazolidin‐2‐ones in high yields. The C−H amination reaction is very general and applicable to benzylic, allylic, propargylic, and completely non‐activated aliphatic C(sp 3 )−H bonds, and it also works for C(sp 2 )−H bonds. The surprisingly simple method can be performed under open flask conditions.
D5.2 - Data Management Plan (Dmp) (2015)

The purpose of the DMP is to provide an analysis of the main elements of the data management policy that will be used by the applications with regard to all the datasets that will be generated by the project. The DMP should ensure that most important aspects regarding data management, like metadata generation, data preservation, and responsibilities, are identified in an early stage of the project. This ensures that data is well-managed during the project and also beyond the end of the project. Data which will be generated in the course of the project include output data of random number generators, PUF output data, measurement data, and source code. As the DMP is an incremental tool, it will be adapted in the course of the project.
Abstract 4404: Comparative in vivo pharmacokinetic properties of antibody-maytansinoid conjugates with alternative non-cleavable linkers (2010)

Abstract Antibody-maytansinoid conjugates (AMCs) are targeted anticancer agents that deliver a highly potent cytotoxic maytansinoid agent (DM1 or DM4) specifically to tumor cells displaying their target antigen. Multiple AMCs are now in clinical testing for treatment of an array of cancers. AMCs can employ either a reducible (“cleavable”) disulfide linkage or a non-reducible (“non-cleavable”) thioether linkage to tether the thiol-containing maytansinoid agent to the antibody. The most advanced AMC, trastuzumab-DM1 (T-DM1), employs a maleimide based thioether bond made using SMCC (N-succinimidyl-4-(N-maleimido-methyl)-cyclohexane-1-carboxylate) linker to tether DM1 to the trastuzumab antibody. Given the interest in AMC's with non-cleavable linkers we initiated a study to evaluate alternative non-cleavable antibody-maytansinoid linkages in vivo. This report describes the results of a pharmacokinetic study to evaluate the relative in vivo stability of antibody maytansinoid conjugates with three different non-cleavable linkers: (1) a maleimido-based thioether linkage between the antibody and the thiol-containing maytansinoid DM1 (huC242-MCC-DM1), (2) an iodoacetamido-based thioether linker (huC242-SIA-DM1), or (3) a non sulfur containing link where the maytansinoid is covalently bound directly to the antibody via an amide bond (huC242-Maytansinoid). The three well characterized conjugates were administered intravenously (10 mg/kg) to CD1 mice and plasma samples were withdrawn via retro-orbital plexus at various time points post injection for determination of concentration of intact conjugate by ELISA methods. The pharmacokinetic data describing conjugate clearance were essentially indistinguishable for all three conjugates, each of which had β phase terminal half-lives of approximately 7.5 days. We did not observe any enhanced instability of the maleimido-based thioether-linked conjugate (huC242-MCC-DM1) compared to the iodoacetamido-based thioether-linked conjugate (huC242-SIA-DM1), as has been reported for auristatin conjugates (Alley et. al. Bioconj. Chem. 2008, 19(3), 759-765). In a separate study, we show that the in vivo half-life of the tritiated conjugate, huC242-MCC-[3H]-DM1, in mouse plasma is similar to the half-life for clearance of total antibody from plasma as measured by ELISA (t1/2,β = 10.5 d vs. 12.6 d, respectively), demonstrating that the huC242-MCC-DM1 conjugate has excellent stability in vivo. We conclude that all three of the non-cleavable conjugate linkages examined here for AMCs (maleimido thioether, acetamido thioether and amide linkage) behave similarly in vivo in terms of plasma stability. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4404.
Lymphocyte migration to the kidney (2006)

The current concept of lymphocyte migration to the kidney that has resulted in a better conceptual understanding of progressive renal diseases has been briefly summarized. Our understanding of the molecules involved in the pathogenesis of various renal diseases may provide new therapeutic choices, and lead to the discovery of gene-based therapeutic options. It is likely that selective intervention of chemokines, at the appropriate phase of a particular disease, may have the therapeutic potential for site- and phase-specific intervention of lymphocyte migration and the progression of renal diseases.
Global Exponential Stabilization of an Underactuated Nonholonomic Airship (2009)

This paper considers the problem of controlling both the planar position and orientation of an underactuated airship with a reduced number of actuators. The airship is a nonholonomic system described by a set of nonlinear equations. A smooth and time-varying coordinate transformation is utilized to reduce the stabilization problem of the airship to that of a simple linear time-invariant system. A new feedback controller is presented for obtaining global exponential stabilization of both the position and orientation of an underactuated airship. The proposed design method is simple and straightforward. Some flight experiments are performed to validate the effectiveness of the proposed controller.
A Bioinspired Soft Swallowing Gripper for Universal Adaptable Grasping (2020)

This article presents the design, fabrication, modeling, and preliminary tests of a bloodworm-inspired soft gripper for universal grasping. The gripper was designed and fabricated based on a toy called water snake wiggly (WSW). The toroidal WSW can evert itself inside-out or outside-in, just like a bloodworm everting its teeth outside to hunt and inside to feed. By driving a WSW rolling itself outside-in to wrap around the items, a bloodworm-inspired gripper was achieved with a flexible and passive form-fitting grasp. To enhance the capability of the gripper, two alternative detachable modules were added to the gripper-a vacuum suction cup for handling objects with smooth nonporous surfaces and an end-needle for taking in and expelling noncorrosive liquids like a syringe. We analyzed the working principles of the gripper and derived the relationship between the gripper's holding force and the objects' scale. Preliminary experiments with a motor-driven gripper prototype were conducted to verify its performance. The experimental results conform well with our theoretical analysis and also indicate the gripper's good universal grasping capacity and reliability in handling a wide range of objects with different surface shapes, geometric dimensions, and stiffness. In addition, the gripper has the unique abilities to pick more than one object during a maneuver, grasp multiple objects in a row without releasing the former ones, and even grasp powdered objects. These have presented a challenge for the existing robotic grippers.
Connecting IT Innovation with Business Value (2012)

You will be as much value to others as you have been to yourself.
A Unified Approach to the Design of Adaptive and Repetitive Controllers for Robotic Manipulators (1990)

A unified approach, based on Lyapunov theory, for synthesis and stability analysis of adaptive and repetitive controllers for mechanical manipulators is presented. This approach utilizes the passivity properties of the manipulator dynamics to derive control laws which guarantee asymptotic trajectory following, without requiring exact knowledge of the manipulator dynamic parameters. The manipulator overall controller consists of a fixed PD action and an adaptive and/or repetitive action for feed-forward compensations. The nonlinear feedforward compensation is adjusted utilizing a linear combination of the tracking velocity and position errors. The repetitive compensator is recommended for tasks in which the desired trajectory is periodic. The repetitive control input is adjusted periodically without requiring knowledge of the explicit structure of the manipulator model. The adaptive compensator, on the other hand, may be used for more general trajectories. However, explicit information regarding the dynamic model structure is required in the parameter adaptation. For discrete time implementations, a hybrid version of the repetitive controller is derived and its global stability is proven. A simulation study is conducted to evaluate the performance of the repetitive controller, and its hybrid version. The hybrid repetitive controller is also implemented in the Berkeley/NSK SCARA type robot arm.
Progress in Interferometer and Resonator Fiber Optic Gyros (1992)

Fiber-optic gyroscopes (FOGs) have been under investigation worldwide for over fifteen years. The interferometer fiber-optic gyro (IFOG) which has received the most attention among the two most basic FOGs, has recently moved out of the purely research and development environment. Efforts now concentrate on productization of early products, environmental ruggedization, size and cost reductions, as well as further performance improvements. The resonator fiber-optic gyro (RFOG), on the other hand, is still in a purely research and development phase. RFOG development efforts, motivated by the potential for using nominally 30X less fiber to achieve comparable performance to the IFOG, are aimed at demonstrating its performance potential. Solutions to key error mechanisms such as polarization-related error mechanisms are now being demonstrated.
Acknowledgment of Reviewers (2016)

On behalf of the editors of mBio, I gratefully acknowledge the following individuals, who served as reviewers for the journal in 2015. Their time and effort in reviewing articles have been essential in ensuring the high quality of our publications, and their help is greatly appreciated.
Synthesis of carbocycles from ω-substituted α,β-unsaturated esters via radical-induced cyclizations (1987)

The intramolecular radical cyclization of ω-bromo α,β-unsaturated esters for the synthesis of carbocyclic compounds is described. The effect of carbon chain substituents, the bulk of the ester group, and the olefin geometry were examined. The highest level of stereoselectivity (trans/cis: 9/1) was achieved with the Z ester via an exo cyclization. The sequential radical cyclization of a dihalodienoate to give a cis-fused bicyclic structure is also described.