gebhart/patrepeval huggingface dataset:
Proceedings of the 22nd ACM international conference on Information & Knowledge Management (2013)

On behalf of the organizing committee, it is our great pleasure to welcome you to the 22nd ACM International Conference on Information and Knowledge Management (CIKM 2013) in San Francisco!

CIKM is a premier ACM conference in the areas of information retrieval, knowledge management and databases. Since 1992, it has successfully brought together leading researchers and developers from the three communities. The purpose of the conference is to identify challenging problems facing the development of future knowledge and information systems, and to shape future research directions through the publication of high quality applied and theoretical research findings. In CIKM 2013, we continue the tradition of promoting collaboration among multiple areas and providing a leading forum in which experts from academia, industry, and government gather to exchange ideas, research results, and technical developments in multidisciplinary research areas.

As one of the world's most recognized conferences in the field, this year CIKM received 848 valid full paper submissions, 233 poster submissions, and 57 demonstration submissions. Among them, we accepted 143 full papers (16.86% acceptance rate), 107 short papers, 81 posters and 21 demos. In addition to regular research tracks, CIKM 2013 features 4 keynote speakers, a panel on Big Data, dedicated Industry events featuring 10 leading industrial practitioners, 10 tutorials from nprestigious researchers and 14 workshops on cutting-edge areas of research. This is a great demonstration of the lively research areas that contribute to the CIKM area. We are proud of our final program and gratefully thank all authors, invited speakers and organizers who chose to contribute their time and research to CIKM 2013.

We are honored to present four distinguished keynote speakers to attendees: Ronald Fagin, Lee Giles, Carlos Guestrin, and Alon Halevy. Their valuable, insightful and interdisciplinary talks will guide us to a better understanding of the field.
Engineering an Alcohol-Forming Fatty Acyl-CoA Reductase for Aldehyde and Hydrocarbon Biosynthesis in Saccharomyces cerevisiae (2020)

Aldehydes are a class of highly versatile chemicals that can undergo a wide range of chemical reactions and are in high demand as starting materials for chemical manufacturing. Biologically, fatty aldehydes can be produced from fatty acyl-CoA by the action of fatty acyl-CoA reductases. The aldehydes produced can be further converted enzymatically to other valuable derivatives. Thus, metabolic engineering of microorganisms for biosynthesizing aldehydes and their derivatives could provide an economical and sustainable platform for key aldehyde precursor production and subsequent conversion to various value-added chemicals. <i>Saccharomyces cerevisiae</i> is an excellent host for this purpose because it is a robust organism that has been used extensively for industrial biochemical production. However, fatty acyl-CoA-dependent aldehyde-forming enzymes expressed in <i>S. cerevisiae</i> thus far have extremely low activities, hence limiting direct utilization of fatty acyl-CoA as substrate for aldehyde biosynthesis. Toward overcoming this challenge, we successfully engineered an alcohol-forming fatty acyl-CoA reductase for aldehyde production through rational design. We further improved aldehyde production through strain engineering by deleting competing pathways and increasing substrate availability. Subsequently, we demonstrated alkane and alkene production as one of the many possible applications of the aldehyde-producing strain. Overall, by protein engineering of a fatty acyl-CoA reductase to alter its activity and metabolic engineering of <i>S. cerevisiae</i>, we generated strains with the highest reported cytosolic aliphatic aldehyde and alkane/alkene production to date in <i>S. cerevisiae</i> from fatty acyl-CoA.
Accurate characterization and compensation of phase noise in OFDM receiver (2011)

Phase noise compensation for OFDM based wireless systems is a necessary task to be performed in order to achieve good performance using cheap components in the transceiver electronics. In this paper, we propose a decision-feedback-frequency-domain compensation method that utilizes Bayesian a priori information of the phase noise process. The a priori information is characterized in terms of the probability density functions of the spectral components of the phase noise process. We show in this work that, for reasonable ratios of phase noise 3dB bandwidth to OFDM subcarrier spacing, the density functions can be expressed as a sum of two independent random variables: The first variable follows a Gaussian distribution while the second variable has a distribution which is a weighted sum of gamma distributions. With this prior knowledge of the probability density functions, we derive the minimum mean square error estimator for spectral components of phase noise which is then used for phase noise compensation.
Fairness-Aware Scheduling in Multi-Numerology Based 5G New Radio (2018)

Multi-numerology waveform based 5G New Radio (NR) systems offer great flexibility for different requirements of users and services. Providing fairness between users is not an easy task due to inter-numerology interference (INI) between multiple numerologies. This paper proposes two novel scheduling algorithms to provide fairness for all users, especially at the edges of numerologies. Signal-to-noise ratio (SIR) results for multi-numerology systems are obtained through computer simulations.
Porcine Immunoglobulin Transfer after Prepartum Treatment with Selenium or Vitamin E (1989)

Responses to prepartum injection of sows with Se and vitamin E (E) were evaluated by determining immunoglobulin (IgA, IgM, IgG) levels in the colostrum and serum of the sows and the serum of their offspring. Fifty-four sows (40 multiparous, 14 primiparous) receiving diets adequate in E and Se according to current NRC (1988) standards were randomly allotted to four treatment groups in which a single i.m. injection of saline (controls), 5 mg of Se, 1,000 IU of E, or both Se and E were given on d 100 of gestation. Sows were bled prior to and 7 d after injection, at farrowing and on d 14 and 28 of lactation. Colostral samples were collected at the initiation of farrowing. Pigs were bled 20 h postpartum and at 14 and 28 d of age. Major immunoglobulin changes in the serum of the sows due to treatment were not seen prior to parturition. Injections of Se and(or) E resulted in higher colostral IgM levels (8.4, 10.7, 9.8 and 9.6 mg/ml, respectively), but only the response from Se was significant (P less than .05). Concentrations of colostral IgA or IgG were not affected by treatment (P greater than .30). Compared with controls, all three treatments increased (P less than .10) IgM concentrations in serum from pigs at birth (28.3, 33.3, 36.0 and 33.5 mg/ml, respectively), whereas IgA and IgG concentrations were not affected (P greater than .30).(ABSTRACT TRUNCATED AT 250 WORDS)
Phonon heat conduction in Al1-xScxN thin films (2021)

Aluminum scandium nitride alloy (Al1-xScxN) is regarded as a promising material for high-performance acoustic devices used in wireless communication systems. Phonon scattering and heat conduction processes govern the energy dissipation in acoustic resonators, ultimately determining their performance quality. This work reports, for the first time, on phonon scattering processes and thermal conductivity in Al1-xScxN alloys with the Sc content (x) up to 0.26. The thermal conductivity measured presents a descending trend with increasing x. Temperature-dependent measurements show an increase in thermal conductivity as the temperature increases at temperatures below 200K, followed by a plateau at higher temperatures (T&gt; 200K). Application of a virtual crystal phonon conduction model allows us to elucidate the effects of boundary and alloy scattering on the observed thermal conductivity behaviors. We further demonstrate that the alloy scattering is caused mainly by strain-field difference, and less by the atomic mass difference between ScN and AlN, which is in contrast to the well-studied Al1-xGaxN and SixGe1-x alloy systems where atomic mass difference dominates the alloy scattering. This work studies and provides the quantitative knowledge for phonon scattering and the thermal conductivity in Al1-xScxN, paving the way for future investigation of materials and design of acoustic devices.
Iberian organ music before 1700 (1999)

Iberian organ music to c1700 is traditional, in that the principles of composition in the works of composers of the siglo de oro, such as Morales and Victoria, are essentially maintained in the various types of organ music through the seventeenth century. There is the lasting impression that, although ornamentation and registration are becoming increasingly elaborate, the musical motet style of c1500 provides the basic technical structure right up to Cabanilles; colour and elaboration are applied within this style rather than constituting a part of some new way of composing, as in French or German late seventeenth-century organ music. Iberian composers, however they may compare for progressiveness and even technical ability with their contemporaries in other European countries, show tremendous musical expressiveness and conviction in their works. It is conspicuous that composers of vocal music (e.g. Morales, Guerrero, Cebollas, Victoria) and those for organ described here are almost mutually exclusive. Organists did not always occupy the position of maestro de capilla: Cabezón was musico de cámara y capilla to Philip II, Aguilera's position in Huesca (Aragon) was designated Portionarius et organis praeceptor, while Correa de Arauxo and Cabanilles were organists in Seville and Valencia respectively. Most likely there were regional characteristics: Francisco Peraza, Diego del Castillo as well as Correa lived in Seville, while Aguilera, Jimenez and Bruna were active in Zaragoza, but because of the relatively small quantity of surviving music and instruments any definite conclusions could be misleading.
A Real-World Systematic Analysis of Driver Mutations’ Prevalence in Early- and Advanced-Stage NSCLC: Implications for Targeted Therapies in the Adjuvant Setting (2022)

The approval of osimertinib for adjuvant treatment of stage I-II-III <i>EGFR</i>-mutated NSCLC (early stage) represents a paradigm shift, raising the question of whether other genotype-matched therapeutics approved for advanced-stage NSCLC can also provide clinical benefit in the adjuvant setting. However, there is a paucity of real-world data on the prevalence of actionable genomic alterations (GAs) in early-stage NSCLC. We used next-generation sequencing, complemented by immunohistochemistry and fluorescence in situ hybridization, to screen our single-institution cohort of 1961 NSCLC consecutive cases for actionable molecular targets. The prevalence of actionable GAs was comparable in early versus advanced-stage NSCLC, the only exception being <i>KRAS</i> mutations (more frequent in early-stage cases). Consistent with advanced-stage tumors being more aggressive, co-occurrence of <i>TP53</i> and <i>EGFR</i> GAs as well as copy number gains were less frequent in early-stage tumors. <i>EGFR</i> mutations and high expression of PD-L1 were inversely associated, whereas <i>KRAS</i> mutations and high PD-L1 reactivity showed positive association. Recapitulating advanced-stage tumors, early-stage NSCLC had the highest share of <i>EGFR</i> mutations in lepidic and acinar subtypes. Resected lepidic tumors contained the highest proportion of the <i>KRAS</i> G12C actionable variant. These results, obtained with routine diagnostic technologies in an unselected clinical setting, provide a significant addition of real-world data in early-stage NSCLC.
Low-temperature thermal graft copolymerization of 1-vinyl imidazole on fluorinated polyimide films with simultaneous lamination of copper foils (1999)

A simple technique of thermal graft copolymerization of 1-vinyl imidazole (VIDZ) on pristine and argon plasma pretreated fluorinated polyimide (FPI) films with simultaneous lamination of copper foils was demonstrated. The simultaneous thermal grafting and lamination process was carried out in the temperature range of 80–140°C under atmospheric conditions and in the complete absence of a polymerization initiator. Three different FPI samples of different chemical structures were employed in the present study. An optimum T-peel strength about 15 N/cm was achieved for the copper/FPI laminate. The adhesion strength, however, decreased with increasing fluorine content in the FPI film. The onset of cohesive failure occurred in the FPI film for assemblies with T-peel strength greater than 6 N/cm. The T-peel strengths are reported as a function of the argon plasma pretreatment time of the FPI films and thermal lamination temperature. The adhesion strengths were compared to that of the similarly prepared copper/polyimide (Kapton HN) laminate. Time-dependent water contact angle (Θ) measurements indicated that the surfaces of FPI films are significantly more hydrophobic and more resistant to water diffusion or hydration than the Kapton HN films. The surface compositions of the pristine FPI films, as well as the delaminated FPI films and copper foils were studied by X-ray photoelectron spectroscopy. The thickness of the graft VIDZ polymer layer was in the order of 200 nm, as derived from the cross-sectional view of the scanning electron micrograph. © 1999 John Wiley & Sons, Inc. J Appl Polym Sci 74: 1478–1489, 1999
Role of the Lipopolysaccharide-CD14 Complex for the Activity of Hemolysin from Uropathogenic Escherichia coli (2006)

Bacterial pathogens produce a variety of exotoxins, which often become associated with the bacterial outer membrane component lipopolysaccharide (LPS) during their secretion. LPS is a potent proinflammatory mediator; however, it is not known whether LPS contributes to cell signaling induced by those microbial components to which it is attached. This is partly due to the common view that LPS present in bacterial component preparations is an experimental artifact. The Escherichia coli exotoxin hemolysin (Hly) is a known inducer of proinflammatory signaling in epithelial cells, and the signal transduction pathway involves fluctuation of the intracellular-Ca(2+) concentration. Since LPS is known to interact with Hly, we investigated whether it is required as a cofactor for the activity of Hly. We found that the LPS/Hly complex exploits the CD14/LPS-binding protein recognition system to bring Hly to the cell membrane, where intracellular-Ca(2+) signaling is initiated via specific activation of the small GTPase RhoA. Hly-induced Ca(2+) signaling was found to occur independently of the LPS receptor TLR4, suggesting that the role of LPS/CD14 is to deliver Hly to the cell membrane. In contrast, the cytolytic effect triggered by exposure of cells to high Hly concentrations occurs independently of LPS/CD14. Collectively, our data reveal a novel molecular mechanism for toxin delivery in bacterial pathogenesis, where LPS-associated microbial compounds are targeted to the host cell membrane as a consequence of their association with LPS.
Supplementary Table S3 from <i>Nedd9</i> Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer (2023)

&lt;p&gt;GWAS studies of NEDD9 variants&lt;/p&gt;
Diffusion of Water Absorbed in Cellulose Fibers Studied with1H-NMR (2001)

The diffusion of water and the cross relaxation between water and cellulose in a hydrated paper system were followed with the Goldman−Shen and the pulsed-field-gradient stimulated-echo NMR pulse sequences as a function of moisture content. The diffusion coefficient measured along the plane of the paper sheet is very sensitive to the moisture content; more water leads to faster diffusion. The cross relaxation rate is independent of moisture content but high enough to severely influence the evaluation of the diffusion data. From the experiments, structural information about the porous network formed by cellulose microfibrils in the interior of the cellulose fibers is obtained.
Mobilization of extracellular Ca2+ by prostaglandin F2α can be modulated by fluoride in 3T3-L1 fibroblasts (1990)

Changes in the intracellular concentration of calcium [( Ca2+]i) have been shown to mediate the physiological effects of certain agonists. Ca2+ mobilization occurs through multiple mechanisms which involve both influx and internal release of Ca2+. Prostaglandin F2 alpha (PGF2 alpha) caused a transient mobilization of intracellular Ca2+ in 3T3-L1 fibroblasts. This effect was characterized by fluorescence measurements of trypsin-treated cells loaded with fura-2/AM. In the absence of extracellular Ca2+, the peak amount of Ca2+ mobilized by PGF2 alpha was decreased by 70%, a lag time before the onset of [Ca2+]i increase was observed, and the rate of rise of [Ca2+]i was slowed. Addition of NaF (10 mM) to fura-2-loaded 3T3-L1 cells caused a dose-dependent increase in [Ca2+]i after a brief (approximately 10 s) lag. Maximal effects (approximately 300 nM) were observed at 5-10 mM-NaF. This effect was dependent on the presence of extracellular Ca2+ and appeared to be independent of inositol phosphate production. After reaching a peak at around 40 s after fluoride addition, [Ca2+]i returned to near-baseline within 120 s. This return of [Ca2+]i to near-baseline after fluoride stimulation and the inability of the cells to respond to a subsequent addition of fluoride indicated that the response to fluoride underwent desensitization. Similarly, the pathway used by PGF2 alpha to mobilize Ca2+ underwent desensitization. Exposure of the cells to a maximally effective concentration of fluoride and subsequent addition of PGF2 alpha produced a [Ca2+]i response to PGF2 alpha which was similar in magnitude and kinetics to that seen for PGF2 alpha in the absence of extracellular Ca2+. Conversely, prior exposure of cells to PGF2 alpha diminished the ability of fluoride to mobilize Ca2+. PGF2 alpha also increased inositol phosphate formation, with a time course and dose-response consistent with its ability to increase [Ca2+]i. Prior exposure of cells to fluoride did not change the time course or dose-response characteristics of PGF2 alpha-induced generation of inositol phosphates. These data suggest that PGF2 alpha and fluoride share a common mechanism of activating Ca2+ influx in 3T3-L1 cells.
Insights into Oil Recovery Mechanism by Nothing-Alternating-Polymer NAP Concept (2021)

Abstract This paper discusses the application of polymer injection in a heavy oil reservoir in the South of the Sultanate of Oman containing oil with a viscosity of 300-800cP underlain by a strong bottom-up aquifer. Due to unfavorable mobility ratio between aquifer water and oil and the development of the sharp cones significant amount of oil remains unswept. To overcome these issues, a polymer injection pilot started in 2013 with three horizontal injectors, located a few meters above the oil/water contact. Initially a polymer solution with a viscosity of 100 cP was continuously injected at high injection rates. However, it was challenging to sustain the injectivity mainly due to surface facilities, water, and polymer quality issues. This resulted in frequent shutdowns of the injectors. Interestingly, the water cut reversal and oil gain continued during the shut-in periods. This observation has led to the development of a new cyclic polymer injection strategy, in which the injection of polymer is alternated with shut-ins. The strategy is referred to as Nothing-Alternating-Polymer (NAP). This paper discusses the oil recovery mechanism from the NAP strategy. A 3D model was constructed to match the actual pilot results and capture the observed behavior. The injected polymer squeezes the cones and partly restores the barrier between the aquifer and the oil column, suppressing the aquifer flux and hence the negative affect of the cones. It was found that during polymer injection, the oil is recovered by conventional mobility and sweep enhancement mechanisms ahead of the polymer front. Additionally, during this stage the injected polymer creates a barrier between the aquifer and the oil column, suppressing the aquifer flux and hence the negative effect of the cones or water channels (blanketing mechanism). Moreover, injection of polymer pushes the oil to the depleted water cones, which is then is produced by the water coming from the aquifer during shut-in period (recharge mechanism). During the shut-in or NAP period, the aquifer water also pushes the existing polymer bank and hence leads to extra oil production. The NAP strategy reduces polymer loss into aquifer and improves the polymer utilization factor expressed in kg-polymer/bbl of oil, resulting in a favorable economic outcome.
A Fast and Accurate Automatic Gain Control for a Wireless Local Area Network Receiver (2005)

In this paper we analyze the automatic gain control (AGC) of an IEEE standard 802.11a compliant wireless local area network (WLAN) receiver. We show an efficient method to solve the problem of obtaining accurate and fast power estimates of the input signal for a huge dynamic range. In particular, we use a mixed signal approach, which has the further advantage of low power consumption. With these estimates we adjust the gains of the amplifiers to obtain the best possible signal at the analog-todigital converters (ADCs) in the WLAN receiver. We discuss the functionality of the AGC and analyze the implemented analog and digital power estimators. For the introduced components, we provide bit- and cycle-true simulation results. 1.
ChemInform Abstract: TOTAL SYNTHESIS OF (.+‐.)‐9‐ISOCYANOPUPUKEANANE (1979)

Abstract Die stereoselektive Synthese der natürlich als (+)‐Enantiomeres vorkommenden Titelverbindung (XII) aus dem Cyclohexenon (I) über die Stufen (II)‐(XI) wird beschrieben.
Synthes Spine Drill Instrumentation (1993)

Synthes Spine Drill Instrumentation. 1690 Russell Rd., P.O. Box 0548, Paoli, PA 19301-1222, phone: (215) 647-9700, fax (215) 647-5696. To order, phone: 1-800-523-0322. The following specific instruments are available from Synthes Spine: Catalog #311.48 tap, 44.5 mm (180 mm/110 mm), $51; Catalog #312.46 double-drill sleeve, 4.5 mm/3.2 mm, $137; Catalog #315.29 three-fluted drill bit, 3.2 mm (195 mm/170 mm), $48; Catalog #396.40 translaminar facet drill guide, $368. Numerous types of spinal stabilization have been developed and tested to increase the probability of obtaining a successful fusion of the lumbosacral spine. These have included a variety of anterior and posterior systems that use screws or hooks combined with plates or rods. Limitations of these systems include: 1) they are relatively time consuming; 2) they have some amount of risk associated with them to the nerve root; 3) they require a significant amount of training to become proficient in their use;...
Potential topoisomerase II DNA-binding sites at the breakpoints of a t(9;11) chromosome translocation in acute myeloid leukemia. (1993)

We have examined a t(9;11)(p22;q23) chromosome translocation in an acute myeloid leukemia of an infant. The breakpoints on the two chromosomes occurred within introns of the involved genes: AF-9 on chromosome 9, and ALL-1 on chromosome 11. Sequence analysis identified heptamers flanking the breakpoints on both chromosomes 9 and 11, suggesting that the V-D-J recombinase was involved in the translocation. The presence of an N-region between the two chromosomes supports the hypothesis that a mistake in V-D-J joining was involved in the genesis of the translocation and indicates that terminal deoxynucleotidyl transferase was expressed in the cells from which this acute myeloid leukemia originated. In addition, potential topoisomerase II DNA-binding sites were found near the breakpoints of both chromosomes, suggesting the involvement of altered topoisomerase II activity in this translocation. Altered topoisomerase II activity in the presence of an active V-D-J recombinase may be a pathogenetic mechanism of acute myeloid leukemia with rearrangements at 11q23.