gebhart/patrepeval huggingface dataset:
Isolation and characterization of a candidate gene for progressive myoclonus epilepsy on 21q22.3 (1995)

The Unverricht-Lundborg type of progressive myoclonus epilepsy (EPM1) and autoimmune polyglandular disease type I (APECED) have been mapped to human chromosome 21q22.3 by genetic linkage analysis and/or linkage disequilibrium studies. In order to isolate the genes for these disorders, we have constructed BAC contigs in this region and a 14 week trisomy 21 fetal brain cDNA library. A direct cDNA selection technique, modified to permit the recovery 5' and 3' ends of cDNA, was applied to gene identification using the BAC contigs. We have isolated and characterized a novel gene defined by three overlapping but distinct cDNAs of 5, 3, and 3 kb in size all named EHOC-1 (Epilepsy, HOloprosencephaly Candidate-1). This gene maps less than 45 kb centromeric of D21S25, and spans at least 56 kb of genomic DNA. Northern analysis of the 5 kb cDNA revealed that 8, 7.5 and 5.3 kb transcripts are ubiquitously expressed in adult tissues. DNA sequence analysis of the 5 kb cDNA showed a complete coding sequence of 3570 bp that has multiple putative transmembrane domains and has partial homologies to transmembrane proteins including sodium channel proteins. This gene (EHOC-1) is a good candidate for APECED, and particularly for EPM1 because of the location, size, structure and homologies.
Stereoselective Lithiation and Carboxylation of Boc-Protected Bicyclopyrrolidine: Synthesis of a Key Building Block for HCV Protease Inhibitor Telaprevir (2014)

A stereoselective process for the manufacture of bicyclopyrrolidine 7 to 2 has been developed. The process utilizes a stereoselective lithiation/carboxylation sequence. The achiral diamine ligand DPBP induces excellent diastereocontrol, and resolution with (S)-THNA provides the corresponding salt of 8 in high er and dr. Subsequent processing of 8 gives 2 as the oxalate salt in an overall yield of 27% from 7 (based on total molar charge of 7). Compound 2 was obtained with high chemical and chiral purities. The process was successfully demonstrated on >100 kg scale.
Novel structure embedded with dual-diodes and silicon controlled rectifier for high speed I/O applications (2016)

Design trade-offs of a novel structure embedded with a silicon controlled rectifier and dual-diode (DD-SCR) for high speed I/O applications are presented. A metal-bounded DD-SCR exhibiting a high failure current (It2), small on-state resistance (Ron), low voltage overshoot and low parasitic capacitance is introduced as an optimal device for such applications in advanced CMOS processes. Comprehensive characterizations including capacitance and current vs. voltage measured using transmission line pulsing (TLP) and very-fast TLP (VFTLP) are undertaken to demonstrate the DD-SCR performance.
Application of the Rubber Panel Structure for Railway Crossings (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Immune-Mediated Cytotoxicity in Inflammatory Bowel Disease (1990)

Thirty years of research on the role of immune-mediated cytotoxic activity in the tissue injury of inflammatory bowel disease (IBD) has yielded only inconclusive data on the relevance of cytotoxic mechanisms. Two hypotheses have been advanced. One is that the destruction of target cells is mediated by direct recognition of target antigens by cytotoxic cells which in turn triggers lysis. Another hypothesis is that lysis occurs via an indirect bystander mechanism in which cells do not recognize a specific antigen on the target, but upon nonspecific activation release cytokines which are capable of lysing the target. The authors have investigated both hypotheses and studied the role of cytotoxic T cells and cytotoxic rectors released from activated T cells in the destruction of epithelial cells. Elevated levels of cytotoxic T cells were found in peripheral blood lymphocytes of patients with IBD, particularly Crohn's disease. The cytotoxic T cells were contained within the Leu 7+, CD8+ T cell subset and were detected using anti-CD3-triggered lysis. Increased cytotoxic T cell activity was also present within inflamed mucosa of patients with both Crohn's disease and ulcerative colitis. The specific targets of this activity have yet to be determined. Activation of mucosal T cells by antibodies to the T cell receptor (anti-CD3) in organ culture of normal fetal jejunum induces an enteropathy characterized by villous atrophy and crypt cell hyperplasia. This same change is seen near aphthous ulcers in patients with Crohn's disease. Soluble cytokines produced by T cells might be responsible for the mucosa! damage observed in these two models of mucosal injury. The goal of this study was to establish in vitro if cytotoxic cytokines can be released by triggering isolated colonic T cells, and what cytokine interactions are required for killing of colonic epithelial cells. These results demonstrate that human lamina propria lymphocyte T cells, triggered by addition of anti-CD3 and target cells, produce tumour necrosis factor-alpha and interferon-gamma, both of which are required for optimal killing of HT-29. Simultaneous release of these cytokines in the vicinity of epithelial cells during immune responses could play an important role in mucosal damage in IBD. The development of animal models and long term cultures of epithelial cells will allow many advances in research of the role of immune-mediated cytotoxicity in IBD.
Influence of Oral Insulin Supplementation on Carbohydrate, Lipid and Protein Metabolism in Weaned Balb/c Mice (2003)

In the post-weaning period, oral insulin supplementation had a significant effect on plasma glucose levels and lipid profile, as well as on liver weight and protein content in Balb/c mice. The application of these findings in humans should be studied.
Biquadratic Exchange Coupling in Sputtered (100) Fe/Cr/Fe (1996)

We have used Brillouin light scattering, ferromagnetic resonance, magneto-optical Kerr effect, and magnetoresistance to investigate interlayer exchange coupling in $\mathrm{Fe}(40\AA{})/\mathrm{Cr}(t)/\mathrm{Fe}(40\AA{})$ trilayers grown onto MgO(100) in UHV. Unprecedented strong room-temperature biquadratic exchange coupling (BEC) was found for values of the Cr thickness $t$ corresponding to a region where Fe layers are weakly antiferromagnetically coupled. A common feature in both magnetic and transport measurements, which we take as a signature of the BEC, is the presence of sudden discontinuous jumps as the external magnetic field is varied. The results are in excellent agreement with model calculations that coherently take into account the same phenomenological parameters characterizing the anisotropy, Zeeman, and bilinear and biquadratic exchange energies.
MRI phenotypes in MS (2019)

MRI-defined MS phenotypes show high conversion rates characterized by the continuation of either predominant neurodegeneration or inflammation and support the partial independence of these 2 measures. MicroRNA signatures of these phenotypes suggest a role for blood-brain barrier integrity.
Slotted waveguide antenna for wireless applications (2013)

This paper discusses the use of slotted waveguide as antenna in wireless application. They are well suited to be integrated into the structure of the buildings. Radiation pattern is easily controlled by the geometry of the slots.
Prognostic values of L-type amino acid transporter 1 and CD98hc expression in breast cancer (2020)

LAT1 and CD98hc may possess prognostic values in invasive breast cancer. LAT1 may be linked with cancer cell activities and disease progression in breast cancer.
Nonlinear dynamics of multilayered circular microplate under electrostatic actuation (2019)

In this paper we investigate the static and dynamic behavior of an electrically actuated multilayered circular microplate. The dynamic analogue of Von Karman equation is used to model the governing equation of microplate which accounts for different sources of nonlinearities. We employ a multi-mode reduced order model (ROM) of the governing equations based on Galerkin discretization method to solve for governing and compatibility equations. The eigenvalue problem associated with the governing equation is solved numerically for first few natural frequencies and modeshapes. The microplate is then loaded with direct voltage (DC) load until instability phenomena known as static pull-in is observed. Then, the dynamic forced vibration is investigated by actuating the device with DC voltage superimposed by a small AC voltage. We investigate the transition from hardening to softening behavior near primary resonance for a combination of static and dynamic loads. A MEMS device is fabricated from a polyimide layer coated with metals from top and bottom to validate the theoretical simulation results with the experimental results. The simulated theoretical results are in good agreement with the experiments
60 GHz blockage study using phased arrays (2017)

The millimeter wave (mmWave) frequencies offer the potential for enormous capacity wireless links. However, designing robust communication systems at these frequencies requires that we understand the channel dynamics over both time and space: mmWave signals are extremely vulnerable to blocking and the channel can thus rapidly appear and disappear with small movement of obstacles and reflectors. In rich scattering environments, different paths may experience different blocking trajectories and understanding these multi-path blocking dynamics is essential for developing and assessing beamforming and beam-tracking algorithms. This paper presents the design and experimental results of a novel measurement system which uses phased arrays to perform mmWave dynamic channel measurements. Specifically, human blockage and its effects across multiple paths are investigated with only several microseconds between successive measurements. From these measurements we develop a modeling technique which uses low-rank tensor factorization to separate the available paths so that their joint statistics can be understood.
Transcriptional Profiling of CD4 T Cells Identifies Distinct Subgroups of HIV-1 Elite Controllers (2010)

Human immunodeficiency virus type 1 (HIV-1) elite controllers maintain undetectable levels of viral replication in the absence of antiretroviral therapy (ART), but their underlying immunological and virological characteristics may vary. Here, we used a whole-genome transcriptional profiling approach to characterize gene expression signatures of CD4 T cells from an unselected cohort of elite controllers. The transcriptional profiles for the majority of elite controllers were similar to those of ART-treated patients but different from those of HIV-1-negative persons. Yet, a smaller proportion of elite controllers showed an alternative gene expression pattern that was indistinguishable from that of HIV-1-negative persons but different from that of highly active antiretroviral therapy (HAART)-treated individuals. Elite controllers with the latter gene expression signature had significantly higher CD4 T cell counts and lower levels of HIV-1-specific CD8(+) T cell responses but did not significantly differ from other elite controllers in terms of HLA class I alleles, HIV-1 viral loads determined by ultrasensitive single-copy PCR assays, or chemokine receptor polymorphisms. Thus, these data identify a specific subgroup of elite controllers whose immunological and gene expression characteristics approximate those of HIV-1-negative persons.
New Functional Monomers for Well-Controlled ROMP Polymerizations (2001)

The ring-opening metathesis polymerization of cyclobutene-containing monomers based on the endo-tricyclo[4.2.2.02,5]deca-3,9-diene structure bearing cyclic anhydride and N-alkyl- or N-phenyl-substituted succinimides at the 7- and 8-positions was investigated. Well-defined molybdenum and ruthenium complexes were used as catalysts. Cl2Ru(CHPh)(PCy3)2 (III) was shown to be the most suitable catalyst as a well-controlled and even living polymerization was observed. Mainly cis stereochemistry (≈75%) was observed in the main chain. Kinetic studies with different substituted succinimide moieties indicated that the polymerization rate depended on electronic effects in the monomer. 19F NMR of fluorinated polymers suggests that through-space interactions between fluorine groups and the main polymer chain occur. These new polymers have a good thermal stability (304 °C < Td < 344 °C). Upon hydrogenation, the N-methylsuccinimide functionalized polymer exhibited a Tg at 285 °C, and the thermal stability increased by about 100 °C.
Single-Step, Spin-on Process for High Fidelity and Selective Deposition (2019)

Processes that enable selective deposition in thin films are desired for advanced patterning applications to reduce overlay demands, but conventional techniques are slow and limited in material scope. Here, we report a method that selectively deposits polymeric coatings on heterogeneous substrates (Cu/SiO2) using spin coating. Unlike traditional approaches that rely on surface pretreatments, herein, selectivity is induced by polymer design that promotes preferential dewetting from one substrate material and uniform wetting on the other. As evidenced by studies with homogeneous surfaces, poly(acrylates) containing semifluorinated pendant groups satisfy this criterion and spontaneously dewet from SiO2 but form continuous films on Cu. When spin coated onto Cu/SiO2 line–space patterns, these semifluorinated polymers selectively coat only the Cu lines without any pre- or postprocessing. Rational design rules have been elucidated that anticipate regimes of selective deposition by correlating the droplet size of dewetted features on homogeneous SiO2 with the dimensions of heterogeneous Cu/SiO2 patterns. The universality of this unique strategy is demonstrated across a library of polymers with varying molecular weights and monomer structures, providing significant advances arising from the simplicity and rapidity of spin coating. For 10–40 μm full pitch features, the entire deposition procedure involves a single step and is complete in under 1 min.
Improvement of Visible‐Light H2 Evolution Activity of Pb2Ti2O5.4F1.2 Photocatalyst by Coloading of Rh and Pd Cocatalysts (2022)

Pb<sub>2</sub> Ti<sub>2</sub> O<sub>5.4</sub> F<sub>1.2</sub> modified with various metal cocatalysts was studied as a photocatalyst for visible-light H<sub>2</sub> evolution. Although unmodified Pb<sub>2</sub> Ti<sub>2</sub> O<sub>5.4</sub> F<sub>1.2</sub> showed negligible activity, modification of its surface with Rh led to the best observed promotional effect among the Pb<sub>2</sub> Ti<sub>2</sub> O<sub>5.4</sub> F<sub>1.2</sub> samples modified with a single metal cocatalyst. The H<sub>2</sub> evolution activity was further enhanced by coloading with Pd; the Rh-Pd/Pb<sub>2</sub> Ti<sub>2</sub> O<sub>5.4</sub> F<sub>1.2</sub> photocatalyst showed 3.2 times greater activity than the previously reported Pt/Pb<sub>2</sub> Ti<sub>2</sub> O<sub>5.4</sub> F<sub>1.2</sub> . X-ray absorption fine-structure spectroscopy, photoelectrochemical, and transient absorption spectroscopy measurements indicated that the coloaded Rh and Pd species, which were partially alloyed on the Pb<sub>2</sub> Ti<sub>2</sub> O<sub>5.4</sub> F<sub>1.2</sub> surface, improved the electron-capturing ability, thereby explaining the high activity of the coloaded Rh-Pd/Pb<sub>2</sub> Ti<sub>2</sub> O<sub>5.4</sub> F<sub>1.2</sub> catalyst toward H<sub>2</sub> evolution.
Agroecology Education and Research: An Academic Platform for Organic Farming (2006)

Agroecology education and research programs are gaining prominence in universities. This emerging field provides an appropriate and convenient platform for bringing organic farming into academia. Agroecology deals with complex systems, uncertainty, and the future. Examples from organic farming and local food systems often provide valuable examples of applications of the principles of ecology in designing a sustainable agriculture. The agroecology MSc program in the NOVA network is a successful example of how organic farming can be brought into university programs, and how interdisciplinary education and research can tap into a regional faculty in agriculture.
Genetic Perturbation of the Maize Methylome (2014)

DNA methylation can play important roles in the regulation of transposable elements and genes. A collection of mutant alleles for 11 maize (Zea mays) genes predicted to play roles in controlling DNA methylation were isolated through forward- or reverse-genetic approaches. Low-coverage whole-genome bisulfite sequencing and high-coverage sequence-capture bisulfite sequencing were applied to mutant lines to determine context- and locus-specific effects of these mutations on DNA methylation profiles. Plants containing mutant alleles for components of the RNA-directed DNA methylation pathway exhibit loss of CHH methylation at many loci as well as CG and CHG methylation at a small number of loci. Plants containing loss-of-function alleles for chromomethylase (CMT) genes exhibit strong genome-wide reductions in CHG methylation and some locus-specific loss of CHH methylation. In an attempt to identify stocks with stronger reductions in DNA methylation levels than provided by single gene mutations, we performed crosses to create double mutants for the maize CMT3 orthologs, Zmet2 and Zmet5, and for the maize DDM1 orthologs, Chr101 and Chr106. While loss-of-function alleles are viable as single gene mutants, the double mutants were not recovered, suggesting that severe perturbations of the maize methylome may have stronger deleterious phenotypic effects than in Arabidopsis thaliana.
Flexible wavelet transforms using lifting (1998)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1998Flexible wavelet transforms using liftingAuthors: Roger L. ClaypooleRichard G. BaraniukRoger L. ClaypooleRice University and Richard G. BaraniukRice Universityhttps://doi.org/10.1190/1.1820329 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1820329FiguresReferencesRelatedDetailsCited ByRedundant Multiscale Haar Wavelet TransformsAlgorithm Considering Signal Correlation for Denoising of the Magnetic Flux Leakage of Wire Rope1 July 2011 | Advanced Materials Research, Vol. 291-294Beyond Wavelets2 December 2010Image enhancement via space-adaptive lifting scheme exploiting subband dependencyDigital Signal Processing, Vol. 20, No. 6A New Approach of Nonlinear Wavelet Transforms for Image Compression and Progressive Image TransmissionGradient-driven update lifting for adaptive waveletsSignal Processing: Image Communication, Vol. 20, No. 9-10 SEG Technical Program Expanded Abstracts 1998ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1998 Pages: 2092 publication data© 1998 Copyright © 1998 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 06 Jan 2005 CITATION INFORMATION Roger L. Claypoole, Jr. and Richard G. Baraniuk, (1998), "Flexible wavelet transforms using lifting," SEG Technical Program Expanded Abstracts : 1979-1982. https://doi.org/10.1190/1.1820329 Plain-Language Summary PDF DownloadLoading ...
An Experimental Apparatus for Two-phase Cooling of High Heat Flux Application using an Impinging Cold Plate and Dielectric Coolant (2020)

Increasing heat transfer rates over smaller area and volumetric footprints are a challenge to electronics cooling. Conventional air-based cooling solutions require larger space for heatsink fins and impose challenges on chassis design. Those challenges of air cooling encourage a shift to a more efficient liquid cooling solution. The more efficient heat transfer performance in a small volume is attributed to high specific heat and latent heat associated with a liquid coolant. In this research, a bench level two-phase experimental setup was built to study the heat transfer and hydraulic performance of a jet impinging cold plate using a dielectric coolant HFE 7000. A copper block heater arrangement was used to mimic a computer chip with a footprint of 1“ × 1” (6.45 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ). Heat transfer performance and pressure drop were compared in single- and two-phase operation at three volumetric flow rates 1.0, 1.25, and 1.75 LPM corresponding to mass fluxes 2005, 2506, and 3509 kg/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> s respectively. The tests were carried out for heat fluxes ranging from 5 to 70 W/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . It is found that thermal resistance remains unchanged in the single-phase regime at lower heat fluxes but then decreases significantly when boiling occurs at high heat fluxes. At lower heat fluxes and high heat fluxes, thermal resistance decreases with flow rate. However, at moderate heat fluxes (27-58 w/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ), the thermal resistance is independent on flow rate. This behavior is attributed to the dominance of nucleate boiling at moderate heat fluxes. Therefore, thermal performance at moderate heat fluxes depends on cold plate design (nucleate site density) rather than flow rate. Pressure drop decreases slightly (less than 7 %) in single phase regime due to the reduction of viscosity with temperature. When two-phase boiling occurs, pressure drop is observed to rise considerably (over 70 %). A high power of 450 w was dissipated at operable base temperature (31 to 85°C) and pressure drop (7 to 24 kpa).
Review of Fast Charging for Electrified Transport: Demand, Technology, Systems, and Planning (2022)

As the number and range of electric vehicles in use increases, and the size of batteries in those vehicles increases, the demand for fast and ultra-fast charging infrastructure is also expected to increase. The growth in the fast charging infrastructure raises a number of challenges to be addressed; primarily, high peak loads and their impacts on the electricity network. This paper reviews fast and ultra-fast charging technology and systems from a number of perspectives, including the following: current and expected trends in fast charging demand; the particular temporal and spatial characteristics of electricity demand associated with fast charging; the devices and circuit technologies commonly used in fast chargers; the potential system impacts of fast charging on the electricity distribution network and methods for managing those impacts; methods for long-term planning of fast charging facilities; finally, expected future developments in fast charging technology and systems.
Anti-Inflammatory Effect of White Wine in CKD Patients and Healthy Volunteers (2015)

Plasma markers of chronic inflammation were significantly reduced in CKD patients during the combined consumption of white wine and olive oil, suggesting a possible anti-inflammatory effect of this nutritional intervention.