gebhart/patrepeval huggingface dataset:
Association of Night Sleep Duration and Ideal Cardiovascular Health in Rural China: The Henan Rural Cohort Study (2021)

<b>Introduction:</b> We aimed to explore the association between night sleep duration and ideal cardiovascular health (ICH) among Chinese rural population. <b>Methods:</b> In all, 35,094 participants were included from the Henan Rural Cohort study. Information on sleep was collected using the Pittsburgh Sleep Quality Index. The ICH scores were evaluated. The associations between night sleep duration and ICH were examined using both linear regression and logistic regression models. <b>Results:</b> The mean night sleep duration for all participants was 7.75 ± 1.28 h. Compared with those with night sleep duration of 7 to <9 h by using linear regression model, a significant decrease in ICH scores was observed for participants with shorter [-0.077 (-0.131, -0.024)] and longer [-0.079 (-0.121, -0.036)] night sleep duration. Compared with 7 to <9 h, longer sleep duration [0.919 (0.851, 0.992)] were associated with decreased odds of ideal CVH. <b>Conclusions:</b> Shorter and longer night sleep duration are negatively associated with ICH among rural population. This suggests that it may be beneficial to include night sleep duration assessment in cardiovascular risk screening.
Molecular orientation and electrical properties in tert‐butylated phthalocyanine thin film fabricated by uniaxial solution coating (2020)

Abstract Molecular orientation, molecular packing structure, and electrical properties of thermally stable phthalocyanine, tert ‐butylated phthalocyanine ( t ‐BuPcH 2 ) in the thin film fabricated by bar‐coating method were investigated. The XRD patterns indicated that the columns composed of t ‐BuPcH 2 molecules formed hexagonal structure, the axis of which was parallel to the bar‐sweep direction, and t ‐BuPcH 2 molecules were vertically aligned to the bar‐sweep direction. Uniaxially oriented thin films of t ‐BuPcH 2 were successfully fabricated on Si substrate covered with polyimide by bar‐coating method, and the field effect mobility of t ‐BuPcH 2 was estimated to be 1.32 × 10 −4 cm 2 V −1 s −1 at maximum. The field effect mobility parallel to the bar‐sweep direction was approximately three times higher than that perpendicular to the bar‐sweep direction due to high electrical conduction along the column axis of t ‐BuPcH 2 .
[A way of thinking of a MAB therapy for local/locally advanced prostate cancer: the theory and recent evaluation]. (2007)

The MAB (Maximal Androgen Blockade) therapy is a treatment to exert maximal effects of hormone therapy, inhibiting androgen activity derived from both testes and adrenal gland that promotes proliferation of prostate cancer, being proposed by Dr. Labrie et al. in 1980s. For efficacy of the MAB therapy, a meta-analysis of randomized control studies with metastatic prostate cancer realized primarily in Europe and America showed the survival benefit of MAB therapy using nonsteroidal antiandrogen agent, which have placed it as a standard therapy for metastatic prostate cancer. However, it was suggested that the better effect of MAB therapy was expected in patients without distant metastasis rather than patients with metastatic prostate cancer, and it was noted that the time to progression (TTP) was significantly improved in patients of stage C in a randomized double-blind control study on bicalutamide+LH-RH agonist vs. placebo+LH-RH agonist conducted in Japan. In addition, the clinical study conducted by Dr. Labrie et al. suggested that the patients where the cure was expected did exist by continuing long-term MAB therapy against local prostate cancer. In this discussion meeting, inviting Dr. Labrie, the importance of MAB therapy among the hormone therapy against prostate cancer, the possibility of MAB therapy as a curative treatment against local/locally advanced prostate cancer and the ideal way of application of hormone therapy were discussed, and the significance was showed to conduct a most effective hormone therapy (MAB therapy) in earlier stage where the androgen sensitivity was noted.
Optical images from pathophysiological signals within breast tissue (2007)

Near Infrared (NIR) tomography has the potential for characterization of different tissue types based upon cellular and vascular alternations. This is especially useful for characterizing cancerous regions within normal tissue. Reconstructed images from NIR light propagation measurements through the female breast hold promise of providing clinically useful information about the pathophysiologic change of the tissue. We have developed a fast three-dimensional finite element model and image reconstruction algorithm, NIRFAST and have previously tested the results extensively against simulated and phantom data. The results have shown that the reconstructed images have good accuracy in recovering optical changes within the medium under investigation, and that with appropriate constraints, the calculated quantitative values agree well with the true values. Based on these algorithms, we present true three-dimensional images of the breast, from patient data. These images, which are reconstructed using NIR measurements over a range of wavelengths, provide additional information regarding the blood content and oxygen saturation distribution within the breast.
Monoklonale Antikörper: Chemie, Funktion und Anwendungsmöglichkeiten (1985)

Im Dezember vergangenen Jahres wurde der Nobel-Preis für Medizin oder Physiologie an die Naturforscher N. K. Jerne, C. Milstein und G. Köhler verliehen. Diese drei Immunologen haben grundlegend zum Verständnis der Antikörpersynthese durch die einzelne Immunzelle beigetragen. Die in den sechziger Jahren aufgestellte Regel, aus einer Immunzelle geht nur ein Antikörpertyp hervor, wurde von ihnen allgemein bestätigt und gilt heute als Dogma. Jerne erarbeitete wesentliche Erkenntnisse über die Antikörpervielfalt, und mit seinem Jerne-Plaque-Test (1963) wurde die Darstellung und Analyse einer einzelnen, antikörperproduzierenden Immunzelle in vitro ermöglicht. Damit hatte das Studium der Immunzellinteraktion und der Kooperation von Lymphozytensubpopulationen, die zur Antikörperbildung führt, entscheidende Impulse und wichtige methodische Voraussetzungen erhalten. Köhler und Milstein gelang es 1975, die Antikörperproduktion einer schon immunologisch spezifisch geprägten, sterblichen Immunzelle durch Zellverschmelzung (Hybridisierung) mit einer unsterblichen, krebsartigen Immunzelle (Myelomzelle) auf Dauer zu stabilisieren, d.h. zu immortalisieren. Die Hybridzelle und der daraus gezüchtete Hybridzellklon erzeugen praktisch unbegrenzt und unabhängig von einem animalen Organismus in Zellkultur einen homogenen Antikörper mit der jeweils gewünschten, konstanten Bindungsspezifität, einen monoklonalen Antikörper. Dieser wissenschaftliche Durchbruch war der Anfang einer neuen und enorm stimulierenden, biotechnologischen Entwicklung, die sich mit rasantem Tempo in Laboratorien verschiedener Fachrichtungen ausbreitete und die es heute ermöglicht, naturwissenschaftliche, technische und medizinische Probleme aufzugreifen und teilweise schon zu lösen, die bisher nicht hätten analysiert werden können.
Different hematological diseases induced by type C viruses chemically activated from embryo cells of different mouse strains. (1975)

Type C RNA viruses can be induced by certain chemicals from cells of many mouse strains. Both C58 and BALB/c cells have been shown to contain endogenous viruses that are designated N-tropic because they grow preferentially in cells of NIH Swiss mouse origin. While demonstrating many similar biological and immunological properties, the C58-induced virus is around 10-fold more infectious per physical particle than the N-tropic virus of BALB/c cells. In the present studies, inoculation of these viruses into newborn NIH Swiss mice led to the development of diseases associated with splenomegaly and lymphadenopathy at similar frequency in each group. The disease induced by C58-MuLV was histophathologically diagnosed as lymphoblastic leukemia and was highly malignant following transplantation into newborn mice. The histopathological appearance of spleens from BALB/c virus-affected animals was distinguishable, demonstrating instead myeloid metaplasia or myelogenous leukemia. These findings provide evidence that different endogenous mouse type C viruses can induce distinct diseases in the same mouse strain. Furthermore, they implicate the N-tropic virus endogenous to C58 cells as a major factor in the development of lymphoblastic leukemia that occurs at high frequency in that strain.
Supplementary Appendix from Ultrasound Molecular Imaging in a Human CD276 Expression–Modulated Murine Ovarian Cancer Model (2023)

&lt;p&gt;PDF file - 86K&lt;/p&gt;
Design of an electrically small antenna using a broadside-coupled split ring resonator (2017)

An electrically small planar antenna using a broadside-coupled split ring resonator (BC-SRR) with a simple structure is presented. Due to the capacitance between the two SRRs in the BC-SRR, the resonant frequency of the antenna is lowered without increasing the size of the antenna. The proposed antenna resonates at 2.45 GHz and 7.31 GHz. At 2.45 GHz, the dimension of the SRR in the proposed antenna is as small as 0.012λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> × 0.082λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> , where λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> is the wavelength in vacuum. The radiation efficiency is 24% at 2.45 GHz.
Preliminary Performance Evaluation of the Prototype System for a Brain DOI-PET Scanner: jPET-D4 (2005)

A high-performance brain PET scanner, jPET-D4, which provides depth-of-interaction (DOI) information, is under development. The scanner is designed to achieve not only high spatial resolution but also high scanner sensitivity with the DOI information obtained from multi-layered thin crystals. The scanner has 5 rings of 24 detector blocks each, and the detector block consists of 1,024 GSO crystals of 2.9 mm/spl times/2.9 mm/spl times/7.5 mm, which are arranged in 4 layers of 16/spl times/16 arrays. At this stage, a pair of detector blocks and a coincidence circuit has been assembled into an experimental prototype gantry. In this paper, as a preliminary experiment, we have investigated the performance of the jPET-D4's inherent spatial resolution and noise characteristics using the prototype system. Spatial resolution and background noise were measured by using a line source and a uniform cylinder phantom respectively. To avoid systematic error and reduce computational cost in image reconstruction, the DOI compression (DOIC) method followed by the ML-EM with accurate system modeling, that we have previously proposed, was applied. Experimental results showed that the JPET-D4 achieves less than 3 mm spatial resolution over the field-of-view. Trade-off results between spatial resolution and background noise also promise an excellent performance of the scanner.
Blockchains and Stealth Tactics for Teaching Security (2020)

Presents the introductory editorial for this issue of the publication.
TCP-Friendly Rate Control with Token Bucket for VoIP Congestion Control (2005)

TCP Friendly Rate Control (TFRC) is a congestion control algorithm that provides a smooth transmission rate for real-time network applications. TFRC refrains from halving the sending rate on every packet drop, instead it is adjusted as a function of the loss rate during a single round trip time. TFRC has been proven to be fair when competing with TCP flows over congested links, but it lacks quality-of-service parameters to improve the performance of real-time traffic. A problem with TFRC is that it uses additive increase to adjust the sending rate during periods with no congestion. This leads to short term congestion that can degrade the quality of voice applications. We propose two changes to TFRC that improve the performance of VoIP applications. Our implementation, TFRC with Token Bucket (TFRC-TB), uses discrete calculated bit rates based on audio codec bandwidth usage to increase the sending rate. Also, it uses a token bucket to control the sending rate during congestion periods. We have used ns2, the network simulator, to compare our implementation to TFRC in a wide range of network conditions. Our results suggest that TFRC-TB can provide a quality of service (QoS) mechanism to voice applications while competing fairly with other traffic over congested links.
Data from Knockdown of Oncogenic KRAS in Non–Small Cell Lung Cancers Suppresses Tumor Growth and Sensitizes Tumor Cells to Targeted Therapy (2023)

&lt;div&gt;Abstract&lt;p&gt;Oncogenic KRAS is found in more than 25% of lung adenocarcinomas, the major histologic subtype of non–small cell lung cancer (NSCLC), and is an important target for drug development. To this end, we generated four NSCLC lines with stable knockdown selective for oncogenic KRAS. As expected, stable knockdown of oncogenic KRAS led to inhibition of &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; tumor growth in the &lt;i&gt;KRAS-&lt;/i&gt;mutant NSCLC cells, but not in NSCLC cells that have wild-type &lt;i&gt;KRAS&lt;/i&gt; (but mutant &lt;i&gt;NRAS&lt;/i&gt;). Surprisingly, we did not see large-scale induction of cell death and the growth inhibitory effect was not complete. To further understand the ability of NSCLCs to grow despite selective removal of mutant KRAS expression, we conducted microarray expression profiling of NSCLC cell lines with or without mutant KRAS knockdown and isogenic human bronchial epithelial cell lines with and without oncogenic KRAS. We found that although the mitogen-activated protein kinase pathway is significantly downregulated after mutant KRAS knockdown, these NSCLCs showed increased levels of phospho-STAT3 and phospho–epidermal growth factor receptor, and variable changes in phospho-Akt. In addition, mutant KRAS knockdown sensitized the NSCLCs to p38 and EGFR inhibitors. Our findings suggest that targeting oncogenic KRAS by itself will not be sufficient treatment, but may offer possibilities of combining anti-KRAS strategies with other targeted drugs. &lt;i&gt;Mol Cancer Ther; 10(2); 336–46. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
August 2017: Two Years of Submissions (2017)

TEST 02 - Elsevier's Scopus, the largest abstract and citation database of peer-reviewed literature. Search and access research from the science, technology, medicine, social sciences and arts and humanities fields.
VASH1/2 inhibition accelerates functional recovery of injured nerves (2022)

Abstract Treatments accelerating axon regeneration in the nervous system are still unavailable in the clinic. However, in culture, parthenolide markedly promotes adult sensory neurons’ axon growth by inhibiting microtubule detyrosination. Here, we show that overexpression of vasohibins increases microtubule detyrosination in growth cones and compromises growth in culture and in vivo. Moreover, overexpression of these proteins increases the required parthenolide concentrations to promote axon regeneration, while the knockdown of vasohibins or their enhancer SVBP abolishes parthenolide’s effects, verifying them as pharmacological targets for promoting axon growth. In vivo, repeated intravenous application of parthenolide or its prodrug di-methyl-amino-parthenolide (DMAPT) markedly facilitates regeneration of sensory, motor, and sympathetic axons in injured murine and rat nerves and accelerates functional re-covery. Moreover, orally applied DMAPT was similarly effective in promoting nerve regeneration. Thus, pharmacological inhibition of vasohibins facilitates axon regeneration in different species and nerves, making parthenolide and DMAPT promising drugs for curing nerve injury.
A fast versatile instrument for dynamic optical tomography (2000)

Instrumentation suitable for acquiring fast (up to 150 Hz) multi-source, multi-detector optical measurements from tissues having arbitrary geometries is described. The design rationale and measured performance features of first- and second-generation systems are given. Also shown are representative images derived from experimental studies.
Spatially coupled LDPC codes for decode-and-forward in erasure relay channel (2011)

We consider spatially-coupled LDPC codes for the three terminal erasure relay channel. It is observed that BP threshold value of spatially-coupled LDPC codes, in particular spatially-coupled MacKay-Neal code, is close to the theoretical limit for the relay channel. Empirical results suggest that spatially-coupled LDPC codes have great potential to achieve theoretical limit of a general relay channel.
Biomolecule Electrostatic Optimization with an Implicit Hessian (2004)

Computational rational drug design is the application of computer simulation techniques to improve screening processes for new drugs or to design them de novo. The goal is to identify molecules that have high affinity and specificity for a target molecule. Optimizing the electrostatic binding free energy is tractable under certain assumptions as a quadratic optimization problem, but computationally expensive simulations have traditionally been required to determine the associated Hessian. Prior work showed that significant performance gains could be achieved by coupling physical simulation directly to the optimization process and avoiding the calculation of the Hessian. The present paper details recent improvements to this method and the implementation of a practical, full-scale code. Computational results demonstrate the code’s efficiency on large problems and accuracy solving a realistic biomolecule optimization problem.
SHBG Gene Promoter Polymorphisms in Men Are Associated with Serum Sex Hormone-Binding Globulin, Androgen and Androgen Metabolite Levels, and Hip Bone Mineral Density (2006)

Our findings demonstrate that polymorphisms in the SHBG promoter predict serum levels of SHBG, androgens, and glucuronidated androgen metabolites, and hip BMD in men.
Research in academic medical centers: Two threats to sustainable support (2015)

Reductions in federal support and clinical revenue jeopardize biomedical research and, in turn, clinical medicine.
ChemInform Abstract: GENERATION AND UTILIZATION OF COPPER(I) ATE COMPLEXES FROM DIASTEREOMERIC AND ENANTIOMERIC ALKYLMERCURY REAGENTS (1974)

Abstract Die Reaktion von Alkylquecksilberhalogeniden mit Jodo‐tributylphosphinkupfer(I) und tert.‐Butyllithium bei ‐78°C in THF liefert einen reaktiven Komplex, der alle dr Metalle zu enthalten scheint.
Search for lepton-flavor violating decays of heavy resonances and quantum black holes to eμ final states in proton-proton collisions at $$ \sqrt{s}=13 $$ TeV (2018)

A bstract A search is reported for heavy resonances decaying into e μ final states in proton-proton collisions recorded by the CMS experiment at the CERN LHC at $$ \sqrt{s}=13 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>13</mml:mn> </mml:math> TeV, corresponding to an integrated luminosity of 35.9 fb −1 . The search focuses on resonance masses above 200 GeV. With no evidence found for physics beyond the standard model in the e μ mass spectrum, upper limits are set at 95% confidence level on the product of the cross section and branching fraction for this lepton-flavor violating signal. Based on these results, resonant τ sneutrino production in R-parity violating supersymmetric models is excluded for masses below 1.7 TeV, for couplings λ 132 = λ 231 = λ 311 ′ = 0.01. Heavy Z ′ gauge bosons with lepton-flavor violating transitions are excluded for masses up to 4.4 TeV. The e μ mass spectrum is also interpreted in terms of non-resonant contributions from quantum black-hole production in models with one to six extra spatial dimensions, and lower mass limits are found between 3.6 and 5.6 TeV. In all interpretations used in this analysis, the results of this search improve previous limits by about 1 TeV. These limits correspond to the most sensitive values obtained at colliders.
Analysis of candidate target genes for mononucleotide repeat mutation in microsatellite instability-high (MSI-H) endometrial cancer (2009)

Microsatellite instability (MSI) is an indicator of DNA instability and is caused by abnormalities in DNA mismatch repair (MMR) genes such as hMLH1, hMSH2 and hMSH6. MSI occurs frequently in endometrial cancer (in approximately 30% of cases), and accumulation of gene mutations due to MSI may therefore have a major role in the mechanism of malignant transformation. However, a responsible target gene has not been identified in endometrial cancer. In this study, we analyzed mutations in 11 cancer-related genes with mononucleotide repeats susceptible to MSI in a coding region [hMSH3 (A8), hMSH6 (C8), TGF-beta RII (A10), MBD4 (A10), BAX (G8), PTEN (A6 in exon 7), HDAC2 (A9), EPHB2 (A9), Caspase-5 (A10), TCF-4 (A9) and Axin2 (G7)] in 22 patients with MSI-H sporadic endometrial cancer. Mutations in hMSH6 (C8) and TGF-beta RII (A10) were found most frequently, at rates of 36.3% (8/22) each. Mutations of BAX (G8) and TCF-4 (A9), which are common in MSI-positive colorectal cancer, occurred at rates of 22.7 and 0%, respectively, which suggests that the MSI target gene may differ between endometrial and colorectal cancers. Mutations in hMSH6 (C8) were correlated with reduced protein expression (p=0.042) and patients with these mutations had significantly more mutations in mononucleotide repeats in other cancer-related genes compared to patients without hMSH6 (C8) mutations (p=0.042). This suggests the possibility of a novel cascade in carcinogenesis of endometrial cancer in which MSI mutates hMSH6 (C8), increases gene instability, and leads to accumulation of mutations in other cancer-related genes. To our knowledge, this is the first report to show that hMSH6 (C8) has an important role as an MSI target gene in sporadic endometrial cancer.
Risk Factors for Colorectal Neoplasia in Inflammatory Bowel Disease: A Nested Case?Control Study From Copenhagen County, Denmark and Olmsted County, Minnesota (2007)

Subgroups of IBD patients-those with PSC, severe long-standing disease, and exposure to x-ray-were at greater risk of colorectal neoplasia. The protective effect of close follow-up, colonoscopy, and treatment with 5-aminosalicylates was questionable.
Up-Regulation of Angiopoetic Signaling and Markers of Cardiopathy after Arteriovenous Loop Placement in Patients with Microsurgical Lower Extremity Reconstructions (2019)

Henn, Dominic MD; Abu-Halima, Masood PhD; Kahraman, Mustafa MS; Falkner, Florian MD; Keller, Andreas PhD; Kneser, Ulrich MD; Meese, Eckart PhD; Schmidt, Volker J. MD Author Information
RTMIDI, RTAUDIO, AND A SYNTHESIS TOOLKIT (STK) UPDATE (2005)

This paper presents new and ongoing development efforts directed toward open-source, cross-platform C++ “tools” for music and audio programming. RtMidi provides a common application programming interface (API) for realtime MIDI input and output on Linux, Windows, Macintosh, and SGI computer systems. RtAudio provides complementary functionality for realtime audio input and output streaming. The Synthesis ToolKit in C++ (STK) is a set of audio signal processing and algorithmic synthesis classes designed to facilitate rapid development of music synthesis and audio processing software. 1.