gebhart/patrepeval huggingface dataset:
Changing Pattern of Clinical Illness in Children with Group A Streptococcal Bacteremia (1993)

The number of cases of severe gas disease has increased in the past several years, and gas infection should be included in the differential diagnosis of seriously ill children, gas infection must be managed aggressively with vigilance for additional deep tissue involvement, even while on appropriate antimicrobial therapy.
L-Asparaginase: Clinical, Biochemical, Pharmacological, and Immunological Studies (1971)

Forty patients with acute leukemia were treated with Intravenous L-asparaginase in doses ranging from 10 to 1,000 international units/kg body weight per day for 2 to 20 days. Most had long-standing disease and had exhausted conventional therapy. The remission rate appeared to be unaffected by dose, schedule, or previous chemotherapy. There was a 66% response rate for acute lymphoblastic leukemia and an approximately 12% response rate for nonlymphocytic leukemia. Second and third remissions were obtained. Toxicity was not strictly dose related and consisted of fever, anorexia, nausea, vomiting, decreased protein synthesis, biochemical hepatic dysfunction, elevated blood ammonia, nonketotic hyperglycemia, and anaphylaxis. Although there were two deaths directly attributed to L-asparaginase, most patients tolerated the enzyme well with very little impairment of performance status. The rapid clearance of plasma enzyme and the development of passive hemagglutinating and reagin types of antibodies are correlated with the development of anaphylaxis. The relationship of plasma L-asparagine to disease status is discussed.
Novel Mitral Repair Device for the Treatment of Severe Mitral Regurgitation: Preclinical Ovine Acute and Chronic Implantation Model (2014)

Objective A project is now underway to implement a novel percutaneous mitral repair system for severe mitral regurgitation (MR). The initial phase of the project consists of proof-of-concept by testing device characteristics using open surgical implantation. When surgical proof-of-concept of the intended percutaneous design is completed, a second phase of the project will consist of in vivo testing of the percutaneous transseptal system. The device is currently being designed to fold into a 17F catheter system and to unfold within the left atrium where attachment is accomplished using a reversible anchoring system. The purpose of this study was to show functionality of the device in elimination of MR using the open surgical method. Methods We have performed surgical prototype device implantation in 5 acute and 7 chronic sheep preparations. We created a P2-flail model of severe (4+) MR in the 12 sheep. Via a minimally invasive left thoracotomy incision and open repair on cardiopulmonary bypass, the device was implanted to determine efficacy of elimination of severe MR. Implantation was considered successful if 4+ regurgitation was converted to 1+ MR or lower. Left ventriculography and epicardial 2-dimensional/3-dimensional echocardiography were used to assess repair; serial 2-dimensional/3-dimensional transthoracic echocardiography was used to assess long-term mitral repair status. Results Twelve sheep had surgical creation of severe (4+) MR by cutting all chordae to the P2 scallop of the mitral valve; this preparation was tested and was found to produce 100% acute fatality without repair of the mitral valve. Five sheep had acute implantation of the device with elimination of regurgitation in 5/5 sheep. Seven sheep had chronic (1–7 month) implantation of the device. The device was tested in the chronic model for clinical status, residual regurgitation, thrombosis, and histopathology. All sheep had mitigation of MR and survived to the intended date of death. Conclusions Proof-of-concept of a novel percutaneous mitral repair device has been completed using an ovine P2-flail severe MR model. The device has characteristics that will allow its use in posterior leaflet degenerative disease and functional/secondary MR. Open, minimally invasive, and robotic surgical implantation of the device can also be developed as an alternative to the percutaneous approach.
Prostasin: A Possible Candidate Gene for Human Hypertension (2008)

Genetic variation of the prostasin gene may be implicated in the development of hypertension in youths..
Vorticity imaging of diastolic cardiac inflow by phase-contrast MRI (2005)

A system is proposed for measuring the three dimensional flow pattern of the left ventricle during filling, with sufficient spatial and temporal resolution to characterize vortex behavior. At least one vortex is known to form during diastolic filling and is thought to play a role in cardiac function. Variations in the vorticity field are hypothesized to be sensitive indicators of heart abnormalities. To test this hypothesis, new techniques were developed for high-resolution reconstruction of phase contrast (velocity encoded) MRI data, computation of vorticity from sampled velocities, and 3D display of vorticity information. In preliminary evaluations, these techniques showed an absence of the vortex in patients with congestive heart failure related to diastolic dysfunction.
Thermally Induced Nonlinearities in High-Speed p-i-n Photodetectors (2004)

Nonlinearities in the responsivity of high-speed p-i-n photodetectors at high photocurrents can limit the useful dynamic range in photonic systems. This letter describes a nonlinearity in the quantum efficiency in InGaAs photodetectors designed for applications at 1.5 μm is due to significant ohmic heating of the intrinsic region. Measured changes in responsivity of about 10% at photocurrents of 12 mA are attributed to a thermal bandgap shift, based on comparisons with temperature dependent measurements and a model of ohmic heating.
Bioluminescent assays for ADMET (2007)

Bioluminescent assays couple a limiting component of a luciferase-catalyzed photon-emitting reaction to a variable parameter of interest, while holding the other components constant or non-limiting. In this way light output varies with the parameter of interest. This review describes three bioluminescent assay types that use firefly luciferase to measure properties of drugs and other xenobiotics which affect their absorption, distribution, metabolism, elimination and toxicity. First, levels of the luciferase enzyme itself are measured in gene reporter assays that place a luciferase cDNA under the control of regulatory sequences from ADMET-related genes. This approach identifies activators of nuclear receptors that regulate expression of genes encoding drug-metabolizing enzymes and drug transporters. Second, drug effects on enzyme activities are monitored with luminogenic probe substrates that are inactive derivatives of the luciferase substrate luciferin. The enzymes of interest convert the substrates to free luciferin, which is detected in a second reaction with luciferase. This approach is used with the drug-metabolizing CYP and monoamine oxidase enzymes, apoptosis-associated caspase proteases, a marker protease for non-viable cells and with glutathione-S-transferase to measure glutathione levels in cell lysates. Third, ATP concentration is monitored as a marker of cell viability or cell death and as a way of identifying substrates for the ATP-dependent drug transporter, P-glycoprotein. Luciferase activity is measured in the presence of a sample that supplies the requisite luciferase substrate, ATP, so that light output varies with ATP concentration. The bioluminescent ADMET assays are rapid and sensitive, amenable to automated high-throughput applications and offer significant advantages over alternative methods.
Chapter 1. Semisynthesis Approach of Ecteinascidin 743 (ET-743, Yondelis®) (2012)

For thousands of years natural products obtained from terrestrial sources have played a very important role in health care and prevention of diseases. However, it was not until the nineteenth century (1804) that scientists (Friedrich Serturner) isolated active components (morphine) from various medi...
Supplementary TABLE 2 from Extracellular Vesicles from High-Grade Glioma Exchange Diverse Pro-oncogenic Signals That Maintain Intratumoral Heterogeneity (2023)

&lt;p&gt;Genes coding for protein sets that vary coherently between GSC subtypes within 89- protein signature, were retrieved from TCGA GBM dataset and identified by subtype prediction.&lt;/p&gt;
Protection of Retinal Ganglion Cells by Caspase Substrate-Binding Peptide IQACRG fromN-Methyl-d-Aspartate Receptor-Mediated Excitotoxicity (2010)

These data demonstrate that IQACRG protects RGCs from excitotoxicity in vitro and in vivo. The positive results with subconjunctival administration of P-IQACRG suggest that in the future this treatment may be useful clinically in diseases such as glaucoma and retinal ischemia.
Efficient energy solutions: Enabling smart city deployment (2016)

Today's cities are constantly balancing the need to provide valuable services to their communities, while at the same time face the demand to reduce the cost of operations and maintenance of their infrastructure. The future of the smart city is explicitly tied to having a community based, economically extendable network. These networks are critical for expanding safety and security solutions, enabling other community services as well as leveraging existing infrastructure to support energy efficiency initiatives. This paper discusses the value of a Smart City Solutions platform and the capabilities of such an integrated platform in achieving (1) Energy efficient, sustainable, net zero energy streetlight networks, (2) Self-fund smart city projects, (3) Enhance public safety, and (4) Strengthen municipal resilience.
Toeprinting Assays: Mapping by Blocks to Reverse Transcriptase Primer Extension (2003)

Primer extension inhibition assays, toeprinting, have been used to examine formation of the translational initiation complex (1–16) as well as autogenous regulation of gene expression (17–27) and nucleic acid secondary structure (6, 28–33). A detailed protocol for examining complex formation between ribosome and tRNA at the mRNA ribosome-binding site (RBS) was first published by Hartz et al. (1). Modifications of the toeprint procedure to examine formation of the binary complex between ribosome and RBS were also published by Hartz et al. (6) and Ringquist et al. (7) as have protocols for examining formation of the translational initiation complex in the presence of the translational initiation factors 1, 2, and 3 (3,8,34). Recently, the toeprint method has been used to examine complex formation between RNA and RNA-binding proteins (35–37).
Cyclic Arylene Sulfides:  A Novel Synthesis and Ring-Opening Polymerization (1998)

Oxidative polymerization of aryl disulfides has been carried out under high dilution conditions for the preparation of cyclic arylene sulfides. The readily available diphenyl disulfide and dichloro disulfide with diphenyl sulfide, diphenyl ether, or p-xylene are useful monomers for the synthesis of the corresponding cyclic oligo(thio arylene)s in ∼ 69% yield. The cyclization of dichloro disulfide with p-xylene gives cyclic oligo(thio-2,5-dimethyl-1,4-phenylene) (3c) bearing a disulfide bond with the repeating units ranging from 3 to 10. The free radical ring-opening polymerization of the cyclics leads to the formation of linear poly(thio arylene)s. The obtained poly(thio-2,5-dimethyl-1,4-phenylene) (6c) has a melting temperature of 354 °C, which is 71 °C higher than that of the unsubstituted poly(thio phenylene).
Application of Solvent‐Directed Assembly of Block Copolymers to the Synthesis of Nanostructured Materials with Low Dielectric Constants (2006)

Invers oder nicht invers: Mischungen eines Poly(dimethylacrylamid)-block-polylactid-Copolymers (PDMA-b-PLA) mit Organosilicat-Oligomeren (PMSSQ), die selektiv in der PDMA-Phase eingesperrt sind, bilden je nach Lösungsmittel Micellen oder inverse Micellen. Die Micellenstrukturen sind in das resultierende ausgehärtete Organosilicat eingeprägt, sodass Monolithe bzw. Aggregate dicht gepackter Organosilicat-Nanopartikel erhalten werden. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2006/z601888_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Determining the Coefficients of Fusion and of Weld Deposition at Mechanized Mag-C Welding with Solid Wire and Cored Wires (2014)

In the case of the MAG welding of carbon and low-alloyed steels wires or hollow wires with (rutilic or basic) flux with metallic powder or self-protection are used. In indoors weldings huge quantities of smoke, gases, dust and particles in suspension, etc. get accumulated. These noxious substances produced during the welding process may severely affect the welders health. To improve the welders working conditions, on an international scale, the following are used: welding masks with self-obscurazation and air control; noxious substances vacuum cleaners fitted with filters; MAG welding pistols with gase and smoke absorbing devices. For the improvement of the welders working conditions, producers of welding materials invented hollow wires with (rutilic flux or with metallic powder) with a smoke-reduced emission [1,2,3,4,5].
The acoustic lens design and in vivo use of a multifunctional catheter combining intracardiac ultrasound imaging and electrophysiology sensing (2008)

A multifunctional 9F intracardiac imaging and electrophysiology mapping catheter was developed and tested to help guide diagnostic and therapeutic intracardiac electrophysiology (EP) procedures. The catheter tip includes a 7.25-MHz, 64-element, side-looking phased array for high resolution sector scanning. Multiple electrophysiology mapping sensors were mounted as ring electrodes near the array for electrocardiographic synchronization of ultrasound images. The catheter array elevation beam performance in particular was investigated. An acoustic lens for the distal tip array designed with a round cross section can produce an acceptable elevation beam shape; however, the velocity of sound in the lens material should be approximately 155 m/s slower than in tissue for the best beam shape and wide bandwidth performance. To help establish the catheter's unique ability for integration with electrophysiology interventional procedures, it was used in vivo in a porcine animal model, and demonstrated both useful intracardiac echocardiographic visualization and simultaneous 3-D positional information using integrated electroanatomical mapping techniques. The catheter also performed well in high frame rate imaging, color flow imaging, and strain rate imaging of atrial and ventricular structures.
Effects of Inhomogeneous Gain and Loss on Nitride-Based Vertical-Cavity Surface Emitting Lasers (2009)

Nitride-based vertical cavity surface emitting lasers (VCSEL) with hybrid mirror has been investigated. We further measured the as-grown samples (without top dielectric distributed Bragg reflector) by µ-photoluminescence, scanning near-field optical microscopy, and cathodoluminescence (CL). By different excitation power density, the experimental results indicated that the VCSEL devices have different lasing modes and spot sizes, represented inhomogeneous gain and loss distribution in the whole structure. The non-uniform emission intensity distribution including several bright spots of about 1 to 2 µm was observed for both VCSEL devices and as-grown samples, which was obtained from CL measurement, due to the effect of indium clusters and non-uniform micro-cavity resonant in InGaN multi-quantum wells (MQWs). The results show the significant influence on commercial applications such as light emitting diodes, lasers devices and so on.
Multi-channel partial power DC-DC converter for current balancing of LED strings (2017)

The light-emitting diode (LED) technology is reaching a high penetration in commercial applications oriented to illumination. However, there are some problems associated when the application requires a high output power. The problems are related to the connection of several LED units to reach the voltage and current levels. The voltage-current characteristic of the LEDs is not always the same, specially when a failure occurs. Therefore, when some strings are connected in parallel, the illumination is not uniform if the same voltage is applied to all strings. For that reason, in this paper a multi-channel current balancing driver is proposed. The driver is based on a partial power DC-DC converter architecture. It performs current balancing handling only a portion of the total power delivered by the source, reaching an increased efficiency. Besides, due to the modularity of the architecture, it allows the parallel connection of as many strings as required to use for high power application. Simulations are performed in order to evaluate the converter performance.
A Hardware Prototype of Wideband High-Dynamic Range ADC (2023)

Key parameters of analog-to-digital converters (ADCs) are their sampling rate and dynamic range. Power consumption and cost of an ADC are directly proportional to the sampling rate; hence, it is desirable to keep it as low as possible. The dynamic range of an ADC also plays an important role, and ideally, it should be greater than the signal's; otherwise, the signal will be clipped. To avoid clipping, modulo folding can be used before sampling, followed by an unfolding algorithm to recover the true signal. In this paper, we present a modulo hardware prototype that can be used before sampling to avoid clipping. Our modulo hardware operates prior to the sampling mechanism and can fold higher frequency signals compared to existing hardware. We present a detailed design of the hardware and also address key issues that arise during implementation. In terms of applications, we show the reconstruction of finite-rate-of-innovation signals which are beyond the dynamic range of the ADC. Our system operates at six times below the Nyquist rate of the signal and can accommodate eight-times larger signals than the ADC's dynamic range.
Caractérisation d'interface de hétérojonctions a-Si:H/c-Si par spectroscopie de capacité sous polarisation directe (2005)

National audience
Polar Loop Transmitter for GSM / GPRS / EDGE (Invited Paper) (2005)

An EDGE transmitter using a non- linear GSM type PA is presented. It is based on a Polar Loop architecture that employs separate feedback control of the amplitude and the phase of the output signal. With this approach the problems with AM-to-PM as well as AM-to-AM of the non-linear PA are essentially eliminated. There is no mode change between GMSK and EDGE, and the transmitter operates seamlessly in Multi-slot EGPRS. The polar modulation transmitter meets all the GSM type approval requirements for both EDGE and GMSK in quad band (850/900/1800/1900 MHz). It is part of an RF Subsystem which is in production.
ChemInform Abstract: Enantiomerically Pure α‐Methoxyaryl Acetaldehydes as Versatile Precursors: A Facile Chemo Enzymatic Methodology for Their Preparation. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A solitary protection measure against scan chain, fault injection, and power analysis attacks on AES (2017)

With the increase in usage of low-power electronics in security critical area, demand for secure transmission of private and confidential information is on the rise. Implementation of dedicated hardware for cryptography is essential nowadays, even in the resource-constrained devices, to meet high-security concerns. However, hardware implementation of cryptographic algorithms may result in security vulnerabilities. Scan-chain-based attack (SBA), fault-injection attack (FIA), and power analysis attack (PAA) are three popular cryptanalysis techniques in exploiting vulnerabilities of crypto-chips. Employing multiple strategies for counteracting the attacks results in significant resource overheads in the cryptographic chips. In this paper, we present a novel and solitary approach to prevent either type of attacks on the hardware implementation of Advanced Encryption Standard (AES). Two additional layers, controlled by true random number generator, are introduced in the proposed technique to conceal sensitive data stored in memory bank. One layer permutes and masks intermediate state before storing in registers, and the other layer is used to reconstruct intermediate state at the start of the round operations of AES. With a two-third increase in resource overhead and negligible increase in timing overhead compared to the regular AES datapath, the proposed technique makes the system resilient against SBA, FIA as well as PAA.
Elastomeric Thermal Interface Materials with High Through‐Plane Thermal Conductivity from Carbon Fiber Fillers Vertically Aligned by Electrostatic Flocking (2014)

Electrostatic flocking is applied to create an array of aligned carbon fibers from which an elastomeric thermal interface material (TIM) can be fabricated with a high through-plane thermal conductivity of 23.3 W/mK. A high thermal conductivity can be achieved with a significantly low filler level (13.2 wt%). As a result, this material retains the intrinsic properties of the matrix, i.e., elastomeric behavior.
Sequence-Specific DNA Binding by a Rhodium Complex: Recognition Based on Sequence-Dependent Twistability (1995)

The chemical construction of small molecules targeted to DNA depends upon the sequence-dependent structure of the double helix. Here we describe a new structural element to be considered in the sequence-specific recognition of DNA, sequence-dependent DNA twistability. The importance of sequence-dependent DNA twistability is demonstrated in the DNA recognition properties of a novel synthetic rhodium intercalator, lambda-1-Rh(MGP)2phi5+. This metallointercalator, containing pendant guanidinium groups, binds in the major groove of DNA at subnanomolar concentrations to the 6 base pair sequence 5'-CATATG-3' with enantiospecificity. An essential feature of this recognition is the sequence-specific unwinding of the DNA helix, which permits direct contacts between guanidinium functionalities on the metal complex and guanine residues. Through an assay developed to test for sequence-specific DNA unwinding, a 70 +/- 10 degrees unwinding of the sequence 5'-CATATG-3' is established with specific binding by the metal complex. This sequence-dependent twistability may be an essential feature of the recognition of sequences by DNA-binding proteins and may be exploited in future design.
Immunocytochemical analysis of the secretory pathway of plant cells (1991)

The Golgi apparatus of plant cells is the site of synthesis of complex polysaccharides and glycoproteins. Following their synthesis, the glycoproteins are sorted and then delivered either to vacuoles or to the plasma membrane or the cell wall, whereas all of the complex polysaccharides are secreted into the cell wall. Little is known about how these different synthetic pathways are organized within plant Golgi stacks, and where the secreted molecules are assembled into the cell walls. To address these problems, we have 1) reexamined the structure of plant Golgi stacks in high pressure frozen and freeze-substituted root tips of Arabidopsis and Nicotiana, as well as in sycamore maple suspension culture cells, and 2) used immunocytochemical methods to localize specific types of complex polysaccharides and glycoproteins in root tip cell walls and in Golgi stacks of high pressure frozen sycamore cells.