699 RISK OF P53 EXPRESSION IN UPPER URINARY TRACT UROTHELIAL CARCINOMA: A SYSTEMATIC REVIEW AND META-ANALYSIS (2013)

You have accessJournal of UrologyUrothelial Cancer: upper Tract Tumors (I)1 Apr 2013699 RISK OF P53 EXPRESSION IN UPPER URINARY TRACT UROTHELIAL CARCINOMA: A SYSTEMATIC REVIEW AND META-ANALYSIS Joo Yong Lee, Ki-Seok Jang, Kang Su Cho, Seung Wook Lee, Hong Sang Moon, Yong Tae Kim, Young Deuk Choi, Hae Young Park, Tchun Yong Lee, and Hong Yong Choi Joo Yong LeeJoo Yong Lee Seoul, Korea, Republic of More articles by this author , Ki-Seok JangKi-Seok Jang Seoul, Korea, Republic of More articles by this author , Kang Su ChoKang Su Cho Seoul, Korea, Republic of More articles by this author , Seung Wook LeeSeung Wook Lee Seoul, Korea, Republic of More articles by this author , Hong Sang MoonHong Sang Moon Seoul, Korea, Republic of More articles by this author , Yong Tae KimYong Tae Kim Seoul, Korea, Republic of More articles by this author , Young Deuk ChoiYoung Deuk Choi Seoul, Korea, Republic of More articles by this author , Hae Young ParkHae Young Park Seoul, Korea, Republic of More articles by this author , Tchun Yong LeeTchun Yong Lee Seoul, Korea, Republic of More articles by this author , and Hong Yong ChoiHong Yong Choi Seoul, Korea, Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.255AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The tumor suppressor gene p53 is a key inhibitor of human carcinogenesis and mutations of p53 have been identified in approximately 50% of all human cancers. Previous studies showed correlation between p53 and other factors including high grade, advanced stage or lymphovascular invasion upper urinary tract urothelial carcinoma (UUT-UC). We conducted to determine p53 as a potential risk factor in UUT-UC and systematically reviewed the available evidence. METHODS A comprehensive literature review was performed, from Jan 1991 to Aug 2012, using search engines including PubMed, EMBASE, Cochrane Library, CINAHL and KoreaMed. We manually reviewed references, and two authors independently extracted the data. To assess the quality of the studies, the Scottish Intercollegiate Guidelines Network (SIGN) Methodology Checklist for case-control studies and cohort studies were used. Heterogeneity amongst studies was explored using the Q statistics and HigginsÆs I2 statistic and Begg-Mazumdar rank-correlation test and EggerÆs regression-intercept test were used to provide evidence of publication bias, which was shown as a funnel plot. RESULTS We identified nine case-control trials that fit our criteria from 302 abstracts of original researches. Of the 9 enrolled articles, final assessment results quality was ôlowö in four articles and ômodestö in five articles according to the SIGN checklists. Pathologic stage, histologic grade and gender were evaluated between p53 and non-p53 expression groups in our meta-analysis. For pathologic stage (≥pT3 or <pT3), there was a significant difference between p53 and non-p53 group (OR =0.370, p<0.001). There was also a statistical difference between low and high histologic grade in two groups (OR=0.255, p<0.001). Female patients had significantly higher risk rate than male patients. (OR=2.736, p<0.001) (Figure 1). CONCLUSIONS This meta-analysis suggests that p53 expression in UUT-UC may be correlated with high pathologic stage, high histologic stage and female patients. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e287-e288 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Joo Yong Lee Seoul, Korea, Republic of More articles by this author Ki-Seok Jang Seoul, Korea, Republic of More articles by this author Kang Su Cho Seoul, Korea, Republic of More articles by this author Seung Wook Lee Seoul, Korea, Republic of More articles by this author Hong Sang Moon Seoul, Korea, Republic of More articles by this author Yong Tae Kim Seoul, Korea, Republic of More articles by this author Young Deuk Choi Seoul, Korea, Republic of More articles by this author Hae Young Park Seoul, Korea, Republic of More articles by this author Tchun Yong Lee Seoul, Korea, Republic of More articles by this author Hong Yong Choi Seoul, Korea, Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...