gebhart/patrepeval huggingface dataset:
Gli is activated and promotes epithelial-mesenchymal transition in human esophageal adenocarcinoma (2017)

Esophageal adenocarcinoma (EAC) accounts for the most esophageal cancer cases in the US, and is notoriously aggressive. This study examines the role of Sonic Hedgehog (SHh)/Gli signaling in the regulation of epithelial-mesenchymal transition (EMT), a process tied to invasion and metastasis, in EAC. Gli/EMT protein expression levels were examined by western blot in paired EAC patient tissues (<i>n</i> = 24) and cell lines (OE19, OE33). Functional analyses were performed (siRNA, treatment with Gli-inhibitor, AKT-inhibitor, and N-Shh recombinant proteins) to investigate SHh/Gli signaling and EMT, cell cycle, and prognostic markers in EAC cell lines. MTS, luciferase reporter, qRT-PCR, western blot, wound healing, and transwell assays were executed to analyze pathway activity, cell migration, and invasion. Aberrant Gli1/2 expression was found in EAC patient tissues, and was significantly associated with increased EMT and AKT pathway activity. Stimulation of SHh/Gli resulted in EMT signaling, including expression of E-cadherin, N-cadherin, Vimentin, β-catenin, Snail, and Slug, as well as cell cycle progression at mRNA and protein levels in EAC cell lines. Gli inhibition via small molecule administration and siRNA significantly reduced EMT, decreasing cell mobility and invasion. Both Gli and AKT inhibition rescued E-cadherin expression and suppressed AKT phosphorylation. This study provides evidence for a strong association between aberrant Gli1/2 expression and AKT/EMT markers in EAC; activated SHh/Gli signaling may be a critical component in promoting cell survival, metastases, and resistance to chemotherapy, and represents a promising avenue to target tumor proliferation and mobility.
Comparison of Minimally Invasive and Conventional Open Posterolateral Lumbar Fusion Using Magnetic Resonance Imaging and Retraction Pressure Studies (2006)

The peak IMP generated by the minimally invasive retractor was significantly less than with the open retractor. Postoperatively, less muscle edema was demonstrated after the minimally invasive lumbar spinal fusion, with lower mean T2 and apparent diffusion coefficient measurements supporting the hypothesis that less damage occurs using a minimally invasive approach.
Isolation of a Promoter Region from Chromosomal DNA of Pseudomonas solanacearum for Constructing an Effective Plasmid Vector. (1995)

[in Japanese]
Automated Enhancement of 3D Models (2002)

The acquisition of a 3D model of a real environment can be accomplished using range sensors. In practice, suitable sensors to densely cover a large environment are often impractical. This paper presents ongoing work on the synthesis of 3D environment models from as little as one intensity image and sparse range data. Our method is based on interpolating the available range data using statistical inferences learned from the available intensity image and from those (sparse) regions where both range and intensity information is available. Since we compute the relationship between extisting range data and the images we start with, we do not need to make any strong assumptions about the kind of surfaces in the world (for example we do not need to assume the world exhibits only diffuse reflectance). Experimental results show the feasibility of our method.
Microstructure Formation in Catalyst Layers of PEFC: New Mechanistic Insights from Meso-scale Computer Simulations (2009)

Abstract not Available.
Regulation of CYP1A1 by Indolo[3,2-b]carbazole in Murine Hepatoma Cells (1995)

To determine the basis for unexpected differences in CYP1A1 inducing potencies and efficacies for the diet-derived indole derivative, indolo[3,2-b]carbazole (ICZ) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), we conducted a systematic analysis of events involved in the induced expression of CYP1A1 in murine hepatoma-derived cell lines (Hepa-1). In contrast to the effects of TCDD, induction kinetics and CYP1A1 mRNA half-life were dependent on ICZ concentration, and the response from low doses of inducer was transient due to rapid clearance of ICZ. TCDD and ICZ produced the same maximum response (i.e. equal efficacies) from a TCDD-responsive CAT reporter construct in Hepa-1 cells. When measured by the immediate responses associated with CYP1A1 expression, including cellular uptake of inducer, receptor transformation and binding to DRE (gel mobility shift assay), initiation of transcription (nuclear run-on assay), and short-term accumulation of mRNA (Northern blot assay), ICZ also exhibited an efficacy equal to that of TCDD and a potency that corresponds to its receptor affinity. ICZ is a potent and selective noncompetitive inhibitor of ethoxyresorufin O-deethylase activity (Ki = 1.5 nM). Taken together these results indicate that ICZ is a bifunctional modulator of CYP1A1 expression with intrinsic efficacy equal to that of TCDD.
Reducing Computational Complexity of Eigenvalue Based Spectrum Sensing for Cognitive Radio (2013)

Spectrum sensing of primary users under very low signal-to-noise ratio (SNR) and noise uncertainty is crucial for cognitive radio (CR) systems. To overcome the drawbacks of weak signal and noise uncertainty, eigenvalue-based spectrum sensing methods have been
Insulator-to-quantum-Hall-liquid transition in an antidot lattice (1997)

Measurements are reported of the Hall resistance ${\mathrm{\ensuremath{\rho}}}_{\mathrm{xy}}$ and magnetoresistance ${\mathrm{\ensuremath{\rho}}}_{\mathrm{xx}}$ of a two-dimensional electron gas containing a triangular lattice of approximately circular depleted regions (antidots). The transition from insulator to quantum Hall liquid shows a fixed point where the longitudinal resistance is independent of temperature; scaling exponents are determined. ${\mathrm{\ensuremath{\rho}}}_{\mathrm{xx}}$ and ${\mathrm{\ensuremath{\rho}}}_{\mathrm{xy}}$ oscillate with magnetic flux through the unit cell of the antidot lattice, although the dissipation results from hopping between localized states.
Model Predictive Control of Multi-input Solar-Wind Hybrid System in DC Community with Battery Back-up (2021)

This paper proposes a multi-input hybrid DC microgrid system to combine renewable energy sources like photovoltaics (PV), wind with storage by applying fast adaptive controls based on the Model Predictive Control (MPC) method. The proposed MPC approach will be based on Maximum Power Point Tracking (MPPT) approach, which is used to regulate the DC-DC converters connecting Photovoltaic (PV) sources. Whereas, the wind energy module uses tip-speed ratio based MPPT method for switching control of converter. A back-to-back converter is added to improve the current sharing between the PV panels and wind farm. Also, to enhance the system reliability due to current sharing under varying and unpredictable weather conditions, droop based MPC is implemented to fix the dc bus voltage. The state of charge (SOC) controlled storage unit gives reliability to sustain peak load demands in the proposed DC microgrid system.
ChemInform Abstract: Synthesis, Structure, and Reactions of a Zirconocene‐Cyclohexyne Complex. (1987)

Abstract The Zr complex (IV) is prepared according to the scheme and characterized by 1 H, 13 C, 31 P NMR spectral measurements and X‐ray crystallography.
Variable-Length Constrained Coding and Kraft Conditions: The Parity-Preserving Case (2020)

Previous work by the authors on parity-preserving fixed-length constrained encoders is extended to the variable-length case. Parity-preserving variable-length encoders are formally defined, and, to this end, Kraft conditions are developed for the parity-preserving variable-length setting. Then, a necessary and sufficient condition is presented for the existence of deterministic parity-preserving variable-length encoders for a given constraint. Examples are provided that show that there are coding ratios where parity-preserving variable-length encoders exist, while fixed-length encoders do not.
Liquid mediated direct bonding and bond propagation (2016)

Room temperature and pressure bonding is shown for wafer-to-wafer (W2W) bonding but never for small chips. Usually, thermo-compression bonding (TCB) is employed for die-to-die (D2D) and die-to-wafer (D2W) bonding for 3D and MEMS application. TCB process is itself limited by tool capability and requires pressure and temperature for bonding which is not only time consuming but can induce coefficient of thermal expansion mismatch and damage to back-end-of-line (BEOL) stacks. To address these issue, we propose a liquid mediated direct bonding approach of inorganic dielectric which can be realized at low temperature and atmospheric pressure using a fast pick and place tool.
PD59-05 INCREASED NITRIC OXIDE AUGMENTS THE ACTION OF CSF-1R INHIBITION AGAINST TUMOR ASSOCIATED MACROPHAGES IN CASTRATION RESISTANT PROSTATE CANCER (2020)

targeting these newly identified AR-mediated signals with miRNA-449c-5p may help us to better suppress PCa progression via reducing the development of NED.
Direct detection of immunospecies by capacitance measurements (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDirect detection of immunospecies by capacitance measurementsPierre. Bataillard, Francoise. Gardies, Nicole. Jaffrezic-Renault, Claude. Martelet, Bruno. Colin, and Bernard. MandrandCite this: Anal. Chem. 1988, 60, 21, 2374–2379Publication Date (Print):November 1, 1988Publication History Published online1 May 2002Published inissue 1 November 1988https://doi.org/10.1021/ac00172a011RIGHTS & PERMISSIONSArticle Views468Altmetric-Citations144LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (771 KB) Get e-Alerts Get e-Alerts
Noncircularity exploitation in signal processing overview and application to radar (2008)

With new generation of Active Digital Radar Antenna, there is a renewal of waveform generation and processing approaches, and new strategies can be explored to optimize waveform design and waveform analysis and to benefit of all potential waveform diversity. Among these strategies, building and exploitation of the Noncircularity of waveforms is a promising issue. Up to the middle of the nineties, most of the signals encountered in practice are assumed to be second order (SO) circular (or proper), with a zero second correlation function. However, in numerous operational contexts such as in radio communications, the observed signals are either SO noncircular (or improper) or jointly SO noncircular with a particular signal to estimate, to detect or to demodulate, with some information contained in the second correlation function of the signals. Exploitation of this information in the processing of SO noncircular signals may generate dramatic gain in performance with respect to conventional processing and opens new perspective in signal processing. The purpose of this paper is to present a short overview of the interest of taking into account the potential SO noncircularity of the signals in signal processing and to describe the potential interest of SO noncircular waveforms for radar applications. (50 pages)
cDNA Cloning and Chromosomal mapping of a Predicted Coiled-Coil Proline-Rich Protein Immunogenic in Meningioma Patients (1997)

There is increasing evidence that tumor expressed genes induce immune responses in cancer patients. To identify meningioma expressed antigens, we established a meningioma expression library which was screened with autologous serum. Out of 20 positive cDNA clones eight share high sequence homologies as determined by sequence analysis. These eight clones can be grouped into three classes which differ in length and which are characterized by specific sequence variations. The longest open reading frame was found to be 2412 bp encoding an immunoreactive antigen termed meningioma expressed antigen 6 (MEA6). Using five sequence specific primer pairs, somatic hybrid panel mapping revealed locations of the three classes on several human chromosomes including chromosomes 2, 3, 6, 7, 9, 13 and 14. The mapping results were confirmed by fluorescence in situ hybridization. RT-PCR showed consistent expression of all classes in several meningiomas and additional tissues using the same set of primer pairs as for chromosomal mapping. The expression data were confirmed by northern blot analysis. For the predicted amino acid sequence BLASTX revealed a homology to a human C219-reactive peptide which was previously isolated by an antibody directed against p-glycoprotein. Sequence properties of the MEA protein include an acidic activation domain, a proline-rich region and two coiled-coil domains indicating protein binding and activation functions.
Bio-inspired nanofabrication of barium titanate (2010)

Complex metal oxides such as BaTiO3 are widely sought materials in the ceramic and electronic industries due to their piezoelectric, ferroelectric, and dielectric properties. The synthesis of BaTiO3 typically requires harsh reaction conditions such as high temperature and pressure that provide poor control over composition, crystal structure, and nanoscale morphology. In contrast, living organisms are able to maintain impressive regulation over the crystallization of inorganic materials during naturally occurring mineralization processes. Here, we present a few general principles from biomineralizing systems that can be harnessed for synthetic materials as well as successful bio-inspired approaches that have been demonstrated for the fabrication of BaTiO3 nanostructures.
Characterizing cellular contractility and cytoplasmic flow using spectral domain phase microscopy (2005)

The phase information inherent to spectral domain optical coherence tomography (OCT) processing can be exploited to resolve sub-coherence length displacement variations. Spectral domain phase microscopy (SDPM) is a functional extension of Fourier domain OCT whose common-path topology enables extraordinary phase sensitivity. Here we demonstrate the usefulness of SDPM in three biologically relevant applications: real-time tracking of cell surface displacements of contracting cardiac myocytes, extracting cytoplasmic flow characteristics for a single-celled organism (flow rates ~10-30&#956;m/s), and cellular mechanical responses to cytoskeletal drug treatments. The results of these experiments are corroborated by light microscopy acquired concurrently with the SDPM data.
FIGURE 1 from A Very Long-acting Exatecan and Its Synergism with DNA Damage Response Inhibitors (2023)

&lt;p&gt;PEG-Exa remaining over time at 37°C at pH 5.0–8.4.&lt;/p&gt;
Fully parallel associative memory with human memory type learning model (2007)

In this paper, fully parallel associative memory architecture with learning model is proposed. It uses a mixed digital-analog associative memory for reference pattern recognition and a learning model based on a short and long-term memory similar to that in human brain. In addition a ranking mechanism is used to manage the transition of reference vectors between two memories and an optimization algorithm is used to adjust the reference vectors components as well as their distribution continuously. The main advantage of the proposed model is no need to pre-training phase as well as its hardware-friendly structure which makes it implementable by an efficient LSI architecture without requiring a large amount of resources. The system was implemented on an FPGA platform and tested with real data of handwritten and printed English characters and the classification results found satisfactory.
PMD monitoring in WDM systems for NRZ data using a chromatic-dispersion-regenerated clock (2002)

We demonstrate a polarisation mode dispersion (PMD) monitor for NRZ signals that measures the effects of PMD on a chromatic-dispersion-generated clock tone. In NRZ transmission, no clock tone appears at a detector if the link chromatic dispersion is well compensated. In our method, we introduce fiber-Bragg based chromatic dispersion (negligible PMD) in the feedback loop of the PMD compensator to generate a 10 GHz clock tone within an NRZ signal.
The effect of network delay and media on user perceptions of web resources (2000)

This research experimentally examines the effects of network delays, document type, and various user characteristics on the perceived usability of distributed documents on the internet. Six experimental conditions were analysed: text only documents and documents including text and graphics at three levels of delay. Users were undergraduate and graduate students who reported spending zero to 50 hours per week on the internet. Usability was assessed by analysing responses to questions about ease of locating information, information organization, information quality, and navigation problems. The results showed significant interactions of network delay and document type on subjects' perceptions of quality, organization, navigation, and several additional factors that are important to organizations providing information on the internet. Both the number of hours subjects reported spending using the internet and subjects' self-reported command of the English language were significantly correlated with perceptions of various aspects of the internet sites examined. While the results indicate that internet users may prefer highly graphical web sites, it appears that they are unwilling to tolerate substantial delays. As a result, users in the study preferred plain text documents as delays increased.
Vitamin C Antagonizes the Cytotoxic Effects of Antineoplastic Drugs (2008)

Vitamin C is an antioxidant vitamin that has been hypothesized to antagonize the effects of reactive oxygen species-generating antineoplastic drugs. The therapeutic efficacy of the widely used antineoplastic drugs doxorubicin, cisplatin, vincristine, methotrexate, and imatinib were compared in leukemia (K562) and lymphoma (RL) cell lines with and without pretreatment with dehydroascorbic acid, the commonly transported form of vitamin C. The effect of vitamin C on viability, clonogenicity, apoptosis, P-glycoprotein, reactive oxygen species (ROS), and mitochondrial membrane potential was determined. Pretreatment with vitamin C caused a dose-dependent attenuation of cytotoxicity, as measured by trypan blue exclusion and colony formation after treatment with all antineoplastic agents tested. Vitamin C given before doxorubicin treatment led to a substantial reduction of therapeutic efficacy in mice with RL cell-derived xenogeneic tumors. Vitamin C treatment led to a dose-dependent decrease in apoptosis in cells treated with the antineoplastic agents that was not due to up-regulation of P-glycoprotein or vitamin C retention modulated by antineoplastics. Vitamin C had only modest effects on intracellular ROS and a more general cytoprotective profile than N-acetylcysteine, suggesting a mechanism of action that is not mediated by ROS. All antineoplastic agents tested caused mitochondrial membrane depolarization that was inhibited by vitamin C. These findings indicate that vitamin C given before mechanistically dissimilar antineoplastic agents antagonizes therapeutic efficacy in a model of human hematopoietic cancers by preserving mitochondrial membrane potential. These results support the hypothesis that vitamin C supplementation during cancer treatment may detrimentally affect therapeutic response.
Review: Computed tomographic colonography has high specificity but low-to-moderate sensitivity for detecting colorectal polyps (2005)

DiagnosisNovember 1, 2005Review: Computed tomographic colonography has high specificity but low-to-moderate sensitivity for detecting colorectal polypsManoop S. Bhutani, MD, P. Jay Pasricha, MDManoop S. Bhutani, MDUniversity of Texas Medical Branch, Galveston, Texas, USA (M.S.B., P.J.P.)Search for more papers by this author, P. Jay Pasricha, MDUniversity of Texas Medical Branch, Galveston, Texas, USA (M.S.B., P.J.P.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2005-143-3-078 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareFacebookTwitterLinkedInRedditEmail Source CitationMulhall BP, Veerappan GR, Jackson JL. Meta-analysis: computed tomographic colonography. Ann Intern Med. 2005;142:635-50. https://pubmed.ncbi.nlm.nih.gov/15838071Clinical Impact RatingsGIM/FP/GP: Gastroenterology: References1 Ashar BH, Hughes MT, Marinopoulos SS, et al. Current evidence for the use of emerging radiologic technologies for disease screening. Am J Manag Care. 2005;11:385-92. [PMID: 15974558] Google Scholar2 Sonnenberg A, Delcò F, Bauerfeind P. Is virtual colonoscopy a cost-effective option to screen for colorectal cancer? Am J Gastroenterol. 1999;94:2268-74. [PMID: 10445561] Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Texas Medical Branch, Galveston, Texas, USA (M.S.B., P.J.P.) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails November 1, 2005Volume 143, Issue 3Page: 78KeywordsAdenomasCancer screeningCarbon dioxideColonColonoscopyColorectal cancerComputed axial tomographyEndoscopyHematologic testsInformation storage and retrievalMalignant tumorsProspective studiesSpecificitySurgery ePublished: 9 March 2020 Issue Published: November 1, 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Evidence that Perutz's double-β-stranded subunit structure for β-amyloids also applies to their channel-forming structures in membranes (2006)

Although there is a growing body of evidence that different amyloidoses may have a similar molecular mechanism in common, the many details of this mechanism are not understood. In this study, we propose that there is a common molecular structure of the primary agents of these diseases, namely a small oligomer of Perutz's cylindrical double-beta-stranded subunit for polyglutamine and that this structure, which contains a central water-filled core, can spontaneously integrate into the bilayers of membranes to form aqueous pores. We suggest that this ability to produce permeable channels in appropriate neuronal membranes is a key element in the toxicity of the beta-amyloids. One strong criterion for the stability of the Perutz structure for an amyloid is that it contain approximately 40 or more amino acid residues. We show here that the neurotoxic Abeta amyloids 1-40 and 1-42, related to Alzheimer's disease, spontaneously enter the membranes of intact erythrocytes and cause their lysis but that Abeta 1-38 and Abeta 1-35, which are not neurotoxic, have no observable effects on erythrocytes, supporting our proposal. Other aspects of the proposed mechanism of cytotoxicity of the beta-amyloids are explored.