gebhart/patrepeval huggingface dataset:
Defect localization in museum items with traditional and electronic holographic nondestructive testing (1995)

In this paper some experimental results are presented, related to practical applications of holographic nondestructive technique for inspection of museum items condition, especially in detection of deformation, stress analysis, and defects localization. These results are obtained using the basic principles of traditional double-exposure holographic interferometry as well as electronic speckle pattern interferometry with computer image processing. In the latter case the accuracy in displacement measurements was studied on a test-object. Several museum items have been selected for their condition inspection: a 19th century oil painting, an 18th century icon on wooden panel, and an enameled terra-cotta vase of the 17th century. The described technique can give quite accurate meteorological information, and is also rather promising for rapid qualitative analysis of the object condition before and after restoration, as well as during its storage.
Pathological Roles and Clinical Usefulness of Periostin in Type 2 Inflammation and Pulmonary Fibrosis (2021)

Periostin is known to be a useful biomarker for various diseases. In this article, we focus on allergic diseases and pulmonary fibrosis, for which we and others are now developing detection systems for periostin as a biomarker. Biomarker-based precision medicine in the management of type 2 inflammation and fibrotic diseases since heterogeneity is of utmost importance. Periostin expression is induced by type 2 cytokines (interleukin-4/-13) or transforming growth factor-β, and plays a vital role in the pathogenesis of allergic inflammation or interstitial lung disease, respectively, andits serum levels are correlated disease severity, prognosis and responsiveness to the treatment. We first summarise the importance of type 2 biomarker and then describe the pathological role of periostin in the development and progression of type 2 allergic inflammation and pulmonary fibrosis. In addition, then, we summarise the recent development of assay methods for periostin detection, and analyse the diseases in which periostin concentration is elevated in serum and local biological fluids and its usefulness as a biomarker. Furthermore, we describe recent findings of periostin as a biomarker in the use of biologics or anti-fibrotic therapy. Finally, we describe the factors that influence the change in periostin concentration under the healthy conditions.
Disease mutant analysis identifies a novel function of DAXX in telomerase regulation and telomere maintenance (2014)

Most human cancers depend on the telomerase to maintain telomeres; however, about 10% of cancers are telomerase negative and utilize the alternative lengthening of telomeres (ALT) mechanism. Mutations in the DAXX gene have been found frequently in both telomerase-positive and ALT cells, and how DAXX mutations contribute to cancers remains unclear. We report here that endogenous DAXX can localize to Cajal bodies, associate with the telomerase and regulate telomerase targeting to telomeres. Furthermore, disease mutations that are located in different regions of DAXX differentially impact on its ability to interact with its binding partners and its targeting to Cajal bodies and telomeres. In addition, DAXX knockdown by RNA interference led to reduced telomerase targeting to telomeres and telomere shortening. These findings collectively support a DAXX-centric pathway for telomere maintenance, where DAXX interaction with the telomerase regulates telomerase assembly in Cajal bodies and telomerase targeting to telomeres.
Pierre Lacoste. Les mafias contre la démocratie (1992)

Hunt Charles. Pierre Lacoste. Les mafias contre la démocratie. In: Politique étrangère, n°4 - 1992 - 57ᵉannée. pp. 961-963.
Die intermolekulare Pauson‐Khand‐Reaktion (2005)

Abstract Fünfgliedrige Kohlenstoffringe sind wichtige Bausteine beim Aufbau vieler biologisch aktiver Moleküle, und insbesondere substituierte Cyclopentenone, z. B. Cyclopentenonprostaglandine, weisen eine charakteristische biologische Aktivität auf. Für die Synthese solcher Verbindungen ist die Pauson‐Khand‐Reaktion mit ihrer hohen Effizienz und Atomökonomie eine der Methoden der Wahl. Anwendungen der intermolekularen Pauson‐Khand‐Reaktion waren stets durch die geringe Reaktivität und Selektivität der Alkenkomponente eingeschränkt, auch wenn die Reaktion ursprünglich in dieser intermolekularen Form entdeckt worden war. Speziell in den vergangenen drei Jahren wurden größere Anstrengungen unternommen, um die Einsatzmöglichkeiten der Pauson‐Khand‐Reaktion zu erweitern. Wir geben hier einen umfassenden und bewertenden Überblick über die intermolekulare Pauson‐Khand‐Reaktion auf der Grundlage von Reaktivitätscharakteristiken der Alkenkomponenten. Insbesondere versuchen wir, durch Identifizierung der Reaktivitätsmuster unterschiedlicher Alkenklassen Aufschluss über Erfolge und Misserfolge auf diesem Gebiet zu erlangen.
Electrical and Thermoelectric Properties of Poly(2,7-Carbazole) Derivatives (2009)

A series of alternating poly(2,7-carbazole) derivatives have been synthesized. The evaluation of their thermoelectric properties in doped films revealed high electrical conductivity (up to 500 S/cm) and a relatively high Seebeck coefficient (up to 70 μV/K). The best compromise between these two thermoelectric parameters led to a maximum value of 19 μW m−1 K−2 as the power factor. As observed from X-ray analyses, it has been observed that the high electrical conductivity was obtained with structured polymers. Good air stability was also observed with these thermoelectric polymers.
The W100 pocket on HIV-1 gp120 penetrated by b12 is not a target for other CD4bs monoclonal antibodies (2012)

Our data indicate that the b12 W100 pocket on gp120 is infrequently targeted by CD4bs mabs. This site is therefore not a priority for preservation in vaccines aiming to elicit antibodies targeting the CD4bs.
Uncooled EA/DFB laser for 100-Gbps Ethernet (2008)

Uncooled 1300-nm range 25-Gbps EA/DFB lasers that support cost-effective optical transmitter for 100-Gbps Ethernet has been realized. A wide temperature ranged 12-km transmission with over 9.6-dB dynamic extinction ratio was demonstrated.
Differential braking-based anti-rollover control for non-tilting narrow-track vehicles (2017)

This paper presents an anti-rollover control system for a non-tilting narrow-track four-wheeled vehicle. The control system relies on two independent braking actuators on the rear wheels. The control system, designed to prevent rollover while limiting the reduction of speed, has two key elements: a steady state term that handles the static roll over limits and a dynamic term that intervenes during fast transients. The control system is tuned based on a control oriented model, identified from a multi-body simulator of the vehicle. The paper validates the proposed control system for steady state and dynamic maneuvers and compares the results against an acausal optimal benchmark. This analysis shows that the control system prevents rollover for all velocities and, in the worst case, reduces the velocity of an additional 25% with respect to the acausal optimal benchmark.
Production of leading charged particles and leading charged-particle jets at small transverse momenta inppcollisions ats=8  TeV (2015)

The per-event yield of the highest transverse momentum charged particle and charged-particle jet, integrated above a given ${p}_{\mathrm{T}}^{\mathrm{min}}$ threshold starting at ${p}_{\mathrm{T}}^{\mathrm{min}}=0.8$ and 1 GeV, respectively, is studied in $pp$ collisions at $\sqrt{s}=8\text{ }\text{ }\mathrm{TeV}$. The particles and the jets are measured in the pseudorapidity ranges $|\ensuremath{\eta}|&lt;2.4$ and 1.9, respectively. The data are sensitive to the momentum scale at which parton densities saturate in the proton, to multiple partonic interactions, and to other key aspects of the transition between the soft and hard QCD regimes in hadronic collisions.
Glaucoma detection using different Stratus optical coherence tomography protocols (2006)

The abilities of four different Stratus OCT RNFL thickness protocols to distinguish between eyes with predominantly mild glaucomatous field loss and healthy eyes were very similar. Thus diagnostic accuracy did not differ between high- and regular-resolution protocols, nor between global (full circle) and localized (sector) OCT parameters, which suggests a diffuse component in early glaucomatous RNFL damage.
Synthesis and Biological Evaluation of Triazol-4-ylphenyl-Bearing Histone Deacetylase Inhibitors as Anticancer Agents (2010)

Our triazole-based histone deacetylase inhibitor (HDACI), octanedioic acid hydroxyamide[3-(1-phenyl-1H-[1,2,3]triazol-4-yl)phenyl]amide (4a), suppresses pancreatic cancer cell growth in vitro with the lowest IC(50) value of 20 nM against MiaPaca-2 cell. In this study, we continued our efforts to develop triazol-4-ylphenyl bearing hydroxamate analogues by embellishing the terminal phenyl ring of 4a with different substituents. The isoform inhibitory profile of these hydroxamate analogues was similar to those of 4a. All of these triazol-4-ylphenyl bearing hydroxamates are pan-HDACIs like SAHA. Moreover, compounds 4h and 11a were found to be very effective inhibitors of cancer cell growth in the HupT3 (IC(50) = 50 nM) and MiaPaca-2 (IC(50) = 40 nM) cancer cell lines, respectively. Compound 4a was found to reactivate the expression of CDK inhibitor proteins and to suppress pancreatic cancer cell growth in vivo. Taken together, these data further support the value of the triazol-4-ylphenyl bearing hydroxamates in identifying potential pancreatic cancer therapies.
High-Quality InAsSb Nanowires Grown by Catalyst-Free Selective-Area Metal–Organic Chemical Vapor Deposition (2015)

We report on the first demonstration of InAs1-xSbx nanowires grown by catalyst-free selective-area metal-organic chemical vapor deposition (SA-MOCVD). Antimony composition as high as 15 % is achieved, with strong photoluminescence at all compositions. The quality of the material is assessed by comparing the photoluminescence (PL) peak full-width at half-max (fwhm) of the nanowires to that of epitaxially grown InAsSb thin films on InAs. We find that the fwhm of the nanowires is only a few meV broader than epitaxial films, and a similar trend of relatively constant fwhm for increasing antimony composition is observed. Furthermore, the PL peak energy shows a strong dependence on temperature, suggesting wave-vector conserving transitions are responsible for the observed PL in spite of lattice mismatched growth on InAs substrate. This study shows that high-quality InAsSb nanowires can be grown by SA-MOCVD on lattice mismatched substrate, resulting in material suitable for infrared detectors and high-performance nanoelectronic devices.
[Development of in vivo gene transfer methods towards future gene therapy]. (1997)

More than 100 protocols have been proposed for human gene therapy in the United States, but no effective results have been reported in the gene therapy field. This failure in gene therapy mainly results from the lack of effective gene transfer vectors. As far as somatic gene therapy is concerned, it will be very hard to control systemic disorders even after a much more powerful vector system is developed. However, local disorders will be able to be better regulated by gene therapy. In this regard, cardiovascular diseases will be suitable and promising targets for future gene therapy. Fusigenic viral-liposome, called HVJ-liposome, seems to be an effective tool for gene therapy. In this system, genes, oligonucleotides and proteins can be directly introduced into the cytoplasm by virus-cell fusion. Using HVJ-liposome, restenosis after angioplasty was successfully prevented in rat carotid artery by the introduction of either antisense oligonucleotides against cell-cycle controlling factor or double-stranded oligonucleotides containing E2F binding sites as a decoy. Constitutive nitric oxide synthase gene was also effective in inhibiting of neointima formation in rat carotid artery. These results indicate the possibility of gene therapy to prevent restenosis after angioplasty. We present here novel targets for future gene therapy.
Pretreatment Diagnosis of the Small Renal Mass: Status of Renal Biopsy in the United States of America (2018)

Among members of the American Urological Association, biopsy of a small renal mass remains an underutilized diagnostic procedure, especially in light of 6000 unnecessary surgeries annually; nonuniversity-based urologists and those who see <5 renal mass cases each year infrequently perform a biopsy. Currently, interventional radiologists perform almost all small renal mass biopsies.
Wavelet filtering of magnetotelluric data (2000)

Abstract A method is described for filtering magnetotelluric (MT) data in the wavelet domain that requires a minimum of human intervention and leaves good data sections unchanged. Good data sections are preserved because data in the wavelet domain is analyzed through hierarchies, or scale levels, allowing separation of noise from signals. This is done without any assumption on the data distribution on the MT transfer function. Noisy portions of the data are discarded through thresholding wavelet coefficients. The procedure can recognize and filter out point defects that appear as a fraction of unusual observations of impulsive nature either in time domain or frequency domain. Two examples of real MT data are presented, with noise caused by both meteorological activity and power-line contribution. In the examples given in this paper, noise is better seen in time and frequency domains, respectively. Point defects are filtered out to eliminate their deleterious influence on the MT transfer function estimates. After the filtering stage, data is processed in the frequency domain, using a robust algorithm to yield two sets of reliable MT transfer functions.
Iron (III) Ion Sensor Based on the Seedless Grown ZnO Nanorods in 3 Dimensions Using Nickel Foam Substrate (2013)

In the present work, the seedless, highly aligned and vertical ZnO nanorods in 3 dimensions (3D) were grown on the nickel foam substrate. The seedless grown ZnO nanorods were characterised by field emission scanning electron microscopy (FESEM), high resolution transmission electron microscopy (HRTEM), and X-ray diffraction (XRD) techniques. The characterised seedless ZnO nanorods in 3D on nickel foam were highly dense, perpendicular to substrate, grown along the (002) crystal plane, and also composed of single crystal. In addition to this, these seedless ZnO nanorods were functionalized with trans-dinitro-dibenzo-18-6 crown ether, a selective iron (III) ion ionophore, along with other components of membrane composition such as polyvinyl chloride (PVC), 2-nitopentylphenyl ether as plasticizer (NPPE), and tetrabutyl ammonium tetraphenylborate (TBATPB) as conductivity increaser. The sensor electrode has shown high linearity with a wide range of detection of iron (III) ion concentrations from 0.005 mM to 100 mM. The low limit of detection of the proposed ion selective electrode was found to be 0.001 mM. The proposed sensor also described high storage stability, selectivity, reproducibility, and repeatability and a quick response time of less than 10 s.
Sampling-point-wise digital dynamic focusing in the receive mode of an ultrasonic linear array imaging system (1993)

An ultrasonic linear array system has been developed in which dynamic focusing in the receive mode is performed in a digital fashion at every sampling point. In order to reduce the sampling rate, the analytic signal sampling technique is employed and the required Hilbert transformer is realized by analog 90° phase shifters. An ASIC chip for digital focusing which includes variable sampling clock generators and digital delay devices and adders, has been developed. The experimental results show a proper operation of the system
Who Ate My Memory? Towards Attribution in Memory Management (2023)

To understand applications' memory usage details, engineers use instrumented builds and profiling tools. Both approaches are impractical for use in production environments or deployed mobile applications. As a result, developers can gather only high-level memory-related statistics for deployed software. In our experience, the lack of granular field data makes fixing performance and reliability-related defects complex and time-consuming. The software industry needs lightweight solutions to collect detailed data about applications' memory usage to increase developer productivity. Current research into memory attribution-related data structures, techniques, and tools is in the early stages and enables several new research avenues.
Rational Design, Synthesis, Evaluation, and Crystal Structure of a Potent Inhibitor of Human GAR Tfase:  10-(Trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic Acid, (2003)

Glycinamide ribonucleotide transformylase (GAR Tfase) has been the target of anti-neoplastic intervention for almost two decades. Here, we use a structure-based approach to design a novel folate analogue, 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid (10-CF(3)CO-DDACTHF, 1), which specifically inhibits recombinant human GAR Tfase (K(i) = 15 nM), but is inactive (K(i) > 100 microM) against other folate-dependent enzymes that have been examined. Moreover, compound 1 is a potent inhibitor of tumor cell proliferation (IC(50) = 16 nM, CCRF-CEM), which represents a 10-fold improvement over Lometrexol, a GAR Tfase inhibitor that has been in clinical trials. Thus, this folate analogue 1 is among the most potent and selective inhibitors known toward GAR Tfase. Contributing to its efficacious activity, compound 1 is effectively transported into the cell by the reduced folate carrier and intracellularly sequestered by polyglutamation. The crystal structure of human GAR Tfase with folate analogue 1 at 1.98 A resolution represents the first structure of any GAR Tfase to be determined with a cofactor or cofactor analogue without the presence of substrate. The folate-binding loop of residues 141-146, which is highly flexible in both Escherichia coli and unliganded human GAR Tfase structures, becomes highly ordered upon binding 1 in the folate-binding site. Computational docking of the natural cofactor into this and other apo or complexed structures provides a rational basis for modeling how the natural cofactor 10-formyltetrahydrofolic acid interacts with GAR Tfase, and suggests that this folate analogue-bound conformation represents the best template to date for inhibitor design.
Multichannel polarization stabilization for coherently combined fiber laser arrays (2012)

We demonstrate a simplified approach toward active polarization control in coherently combined laser architectures. By leveraging optical phase dithers applied by a phase controller, polarization error signals are generated for an entire laser array from a single beam sample of the combined output, enabling closed-loop polarization locking of non-polarization-maintaining fibers. The concept is shown to be compatible with both hill-climbing and synchronous multidither phase control methods. Simultaneous phase locking and polarization locking was demonstrated for a five-fiber array with >99% phasing efficiency and >20 dB polarization extinction ratio.
LADS: large-scale automated DDOS detection system (2006)

Many Denial of Service attacks use brute-force bandwidth flooding of intended victims. Such volume-based attacks aggregate at a target&amp;apos;s access router, suggesting that (i) detection and mitigation are best done by providers in their networks; and (ii) attacks are most readily detectable at access routers, where their impact is strongest. In-network detection presents a tension between scalability and accuracy. Specifically, accuracy of detection dictates fine grained traffic monitoring, but performing such monitoring for the tens or hundreds of thousands of access interfaces in a large provider network presents serious scalability issues. We investigate the design space for in-network DDoS detection and propose a triggered, multi-stage approach that addresses both scalability and accuracy. Our contribution is the design and implementation of LADS (Large-scale Automated DDoS detection System). The attractiveness of this system lies in the fact that it makes use of data that is readily available to an ISP, namely, SNMP and Netflow feeds from routers, without dependence on proprietary hardware solutions. We report our experiences using LADS to detect DDoS attacks in a tier-1 ISP.
Reactions of tin(II) and tin(IV) xanthates: crystal structure of Tetrakis(O-ethylxanthato)tin(IV) (1978)

Tin(II) xanthates form adducts with donor molecules and react with excess xanthate to form the tris-xanthato ion, Sn(EtOCS2)3-. No such reactions are observed with tin(IV) xanthates. Reaction of quinolin-8- ol with tin(IV) ethylxanthate results in the replacement of two xanthate moieties by two oxinato ions. &amp;nbsp;&amp;nbsp;&amp;nbsp; The crystal structure of [Sn(EtOCS2)4] has been determined by single-crystal X-ray diffraction at 295 K and refined by least squares to a residual of 0.038 for 2378 'observed' reflections. The tin(IV) coordination environment resembles that observed in the N,N- diethyldithiocarbamate analogue, two of the xanthate ligands being monodentate and coordinating cis [Sn-S, 2.488(2), 2.499(2) ?] in the six-coordinate coordination sphere while the other two ligands are bidentate, the Sn-S distances trans to the monodentate ligands being slightly longer [2.617(2), 2.627(2)?] than the other two [2.562(2), 2.539(2)?]. Crystals are monoclinic, P21/c, a 10.341(5), b 10.465(4), c 21.88(1) ?, ß 98.36(4)°, Z 4.
Low-voltage high-performance switched current memory cell (2002)

A new switched current (SI) memory cell is proposed in the paper. Analysis and simulations show very good properties of the cell. Layout of a sample and hold (SH) circuit composed of the memory cell is also presented. This SH circuit is a basic cell of bilinear integrators and delay lines, being components of one- and two-dimensional SI filters. The method and tools for automated design of such filters are briefly described.
Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors (2004)

4533 Angiogenesis is a complex process that depends on several growth factors including those such as VEGF that are involved in initiation of the formation of new blood vessels and those such as PDGF that are involved in vessel maintainence. Therefore, interfering with both processes may be necessary for efficient inhibition of angiogenesis and tumor growth. We designed GFB-204 a synthetic molecule that potently blocks binding of PDGF and VEGF to their receptors (200-500nM) and subsequently inhibits PDGFR and Flk-1 tyrosine phosphorylation and stimulation of the mitogen-activated kinases Erk1/2. GFB-204 is selective for PDGF and VEGF and does not inhibit EGF, IGF-1 and FGF-stimulation of Erk1/2. GFB-204 inhibits human endothelial cell migration and capillary network formation in vitro and angiogenesis in vivo. Finally, treatment of mice with GFB-204 suppresses human tumor growth and angiogenesis in nude mouse xenografts. These studies have far-reaching implications for the treatment of cancer.