gebhart/patrepeval huggingface dataset:
Upregulation of Dorsal Root Ganglion α2δ Calcium Channel Subunit and Its Correlation with Allodynia in Spinal Nerve-Injured Rats (2001)

Peripheral nerve injury can lead to a persistent neuropathic pain state in which innocuous tactile stimulation elicits pain behavior (tactile allodynia). Spinal administration of the anticonvulsant gabapentin suppresses allodynia by an unknown mechanism. In vitro studies indicate that gabapentin binds to the alpha(2)delta-1 (hereafter referred to as alpha(2)delta) subunit of voltage-gated calcium channels. We hypothesized that nerve injury may result in altered alpha(2)delta subunit expression in spinal cord and dorsal root ganglia (DRGs) and that this change may play a role in neuropathic pain processing. Using a rat neuropathic pain model in which gabapentin-sensitive tactile allodynia develops after tight ligation of the left fifth and sixth lumbar spinal nerves, we found a >17-fold, time-dependent increase in alpha(2)delta subunit expression in DRGs ipsilateral to the nerve injury. Marked alpha(2)delta subunit upregulation was also evident in rats with unilateral sciatic nerve crush, but not dorsal rhizotomy, indicating a peripheral origin of the expression regulation. The increased alpha(2)delta subunit expression preceded the allodynia onset and diminished in rats recovering from tactile allodynia. RNase protection experiments indicated that the DRG alpha(2)delta regulation was at the mRNA level. In contrast, calcium channel alpha(1B) and beta(3) subunit expression was not co-upregulated with the alpha(2)delta subunit after nerve injury. These data suggest that DRG alpha(2)delta regulation may play an unique role in neuroplasticity after peripheral nerve injury that may contribute to allodynia development.
Generating Control Policies for Timed Discrete-Event Systems through Efficient State Space Exploration (2016)

Production systems are event driven and require knowledge of timing of events across all elements of the system particularly when developing policies for production control. A suite of time-dependent models are derived for a class of discrete systems, in particular, an N-Server, N+1-Buffer sequential line. First, time-dependent models for buffers and servers are derived. From the time-dependent server and buffer arrival and departure models the maximum number of entities any buffer in the serial line will experience across all times is derived. One assumption is then relaxed, thereby reducing the capacity of a queue. The transition and block times for all queues and servers are derived and time-dependent models for server and queue arrivals and departures are developed. Lastly, a buffer cluster concept is proposed and a time based parametric model is derived that determines the sizing of the buffer cluster. A reduced time space for which to search for the buffer cluster sizing is derived and a model that determines an optimal buffer clustering policy is presented. Real world production examples are used to illustrate where the models are utilized and discuss several additional applications and benefits of the models.
A totally synthetic (nonporphyrin) iron(II) dioxygen carrier that is fully functional under ambient conditions (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA totally synthetic (nonporphyrin) iron(II) dioxygen carrier that is fully functional under ambient conditionsNorman Herron, James H. Cameron, Gary L. Neer, and Daryle H. BuschCite this: J. Am. Chem. Soc. 1983, 105, 2, 298–301Publication Date (Print):January 1, 1983Publication History Published online1 May 2002Published inissue 1 January 1983https://pubs.acs.org/doi/10.1021/ja00340a029https://doi.org/10.1021/ja00340a029research-articleACS PublicationsRequest reuse permissionsArticle Views92Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Asymmetric Cyclopropanation of Allylic Ethers: Cleavage and Regeneration of the Chiral Auxiliary. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Gonadotropin-Releasing Hormone and Its Agonist Inhibit Testicular Luteinizing Hormone Receptor and Steroidogenesis in Immature and Adult Hypophysectomized Rats* (1980)

The direct effect of gonadotropin-releasing hormone (GnRH) and its agonist on testicular LH receptor and steroidogenesis was studied in hypophysectomized immature and adult rats. Hypophysectomized rats were treated daily with varying doses of GnRH or [des-Gly10,D-Leu6(N alpha Me)Leu7, Pro9-NHEt]GnRH(a potent agonist). Some animals were also treated concomitantly with FSH, PRL, GH and/or LH to prevent the hypophysectomy-induced loss of testicular LH receptor and steroidogenic capacity. At the end of 5 days of treatment, testicular LH/hCG receptor concentration was measured by a [125I]-hCG-binding assay and steroidogenic responsiveness was determinded by in vitro incubations. GnRH and the GnRH agonist reduced testicular LH receptor in control and FSH-treated hypophysectomized immature rats. As little as 0.5 microgram agonist/day induced a greater than 40% decrease in the LH receptor content, whereas GnRH was less potent, with 50 micrograms/day inducing about a 50% decrease. The inhibitory effect of GnRH was shown to be the result of decreases in the concentration of LH receptor rather than changes in the receptor affinity (Kd = 1.1 X 10(-10)M). GnRH did not interfere with the [125I]hCG receptor assay. Treatment with PRL, GH, and FSH, alone or in various combinations, increased the testicular LH receptor content. The stimulatory effect of these pituitary hormones was depressed by concomitant treatment with the GnRH agonist. Similar inhibitory effects of GnRH and the agonist on testicular LH receptor were demonstrated in adult hypophysectomized rats. In vitro studies demonstrated that treatment with the GnRH agonist in vivo inhibited both basal and hCG-stimulated androgen production in FSH-primed immature hypophysectomized rats. Associated with decreases in androgens (testosterone and androstenedione) and reduced androgens (dihydrotestosterone, androstanediol, and androsterone), there was marked suppression of 17 alpha-hydroxylated precursors and C-21 steroid intermediates in animals treated with the GnRH agonist, thus suggesting that the inhibitory effect of the GnRH agonist was associated with possible defects in 17 alpha-hydroxylase and side-chain cleavage enzymes. Likewise, treatment with the GnRH agonist inhibited in vitro testicular steroidogenic responses in adult hypopysectomized rats. These results demonstrate the extrapituitary inhibitory effect of GnRH on testicular LH receptor content and Leydig cell steroidogenesis in immature and adult hypophysectomized rats.
Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B (2020)

Toll-like receptor 8 (TLR8) recognizes pathogen-derived single-stranded RNA fragments to trigger innate and adaptive immune responses. Chronic hepatitis B (CHB) is associated with a dysfunctional immune response, and therefore a selective TLR8 agonist may be an effective treatment option. Structure-based optimization of a dual TLR7/8 agonist led to the identification of the selective TLR8 clinical candidate (<i>R</i>)-2-((2-amino-7-fluoropyrido[3,2-<i>d</i>]pyrimidin-4-yl)amino)-2-methylhexan-1-ol (GS-9688, (<i>R</i>)-<b>7</b>). Potent TLR8 agonism (IL-12p40 EC<sub>50</sub> = 220 nM) and >100-fold TLR7 selectivity (IFN-α EC<sub>50</sub> > 50 μM) was observed in human peripheral blood mononuclear cells (PBMCs). The TLR8-ectodomain:(<i>R</i>)-<b>7</b> complex confirmed TLR8 binding and a direct ligand interaction with TLR8 residue Asp545. Oral (<i>R</i>)-<b>7</b> had good absorption and high first pass clearance in preclinical species. A reduction in viral markers was observed in HBV-infected primary human hepatocytes treated with media from PBMCs stimulated with (<i>R</i>)-<b>7</b>, supporting the clinical development of (<i>R</i>)-<b>7</b> for the treatment of CHB.
Physiologic effects of low-level nutritional support in a mouse model of Klebsiella pneumoniae sepsis (2020)

Sepsis is an illness characterized by high morbidity and mortality, accounting for 1 in 3 hospital deaths, affecting 1 - 3 million adults in the US every year. Among sepsis cases, approximately 12% are complicated by the incidence of hyperglycemia, a condition that is associated with worsened outcomes including higher mortality. Prior work in our lab has shown the association between the provision of early enteral nutritional support with attenuated inflammatory responses, preservation of euglycemia through heightened insulin sensitivity, and improved mean arterial blood pressure in a mouse model of LPS-induced endotoxemia. As this is a sterile and some would argue, unrealistic model of sepsis, the aim of this study was to see if these results could be observed in a bacteremic model of sepsis, with a focus on mortality as one of the primary outcomes. Ten week old male B6 mice were infected with K. pneumoniae (strain ATCC 43816 2x104 CFUs) via oropharyngeal aspiration after implantation of catheters in the femoral artery and femoral vein or stomach. 24hr. post infection, mice were started on low-level infusions of either intravenous dextrose, enteral dextrose, or enteral saline. Blood was sampled at 24hr. intervals. Mice were sacrificed when blood pressure fell below 61mmHg for at least an hour, or at 72hr. post infection. BAL and tissue samples were then collected. At 72hr., mice receiving enteral dextrose had a mortality rate of 27%, compared to 78% in the enteral saline group and 100% in the IV dextrose group. Mice receiving enteral dextrose also maintained euglycemia and cardiovascular homeostasis for the duration of the experiment, compared to IV dextrose mice who became hyperglycemic and hypotensive and enteral saline mice who trended towards hypoglycemia and hypotension. Metrics of inflammation and lung injury were also significantly different between groups in some outcomes. The results of this study suggest the possible therapeutic benefits of early low-level nutritional support in cases of sepsis. Of public health significance, enteral dextrose therapy could be used to decrease the incidence and severity of post-sepsis complication development, specifically loss of muscular and neurological function. It is possible that this is clinically relevant and could have implications for treatment strategies in the future for sepsis.
Collusion-Resilient Revenue In Combinatorial Auctions (2007)

In auctions of a single good, the second-price mechanism achieves, in dominantstrategies, a revenue benchmark that is naturally high and resilient to anypossible collusion.We show how to achieve, to the maximum extent possible, the same propertiesin combinatorial auctions.
1293: Relationship between Prostate-Specific Antigen and Prostate Volume in Korean Men with Benign Prostatic Hyperplasia from Multicenter Study (2005)

You have accessJournal of UrologyModerated Poster, Tuesday, May 24, 2005, 1:00 - 3:00 pm1 Apr 20051293: Relationship between Prostate-Specific Antigen and Prostate Volume in Korean Men with Benign Prostatic Hyperplasia from Multicenter Study Jin Sean Cho, Byung Ha Chung, Se Joong Kim, Young Sig Kim, Chun Il Kim, Hong Sup Kim, Do Hwan Seong, Yun Seob Song, Won Jae Yang, Sang Hyun Cheon, In Rae Cho, Young Deuk Choi, and Sung Joon Hong Jin Sean ChoJin Sean Cho More articles by this author , Byung Ha ChungByung Ha Chung More articles by this author , Se Joong KimSe Joong Kim More articles by this author , Young Sig KimYoung Sig Kim More articles by this author , Chun Il KimChun Il Kim More articles by this author , Hong Sup KimHong Sup Kim More articles by this author , Do Hwan SeongDo Hwan Seong More articles by this author , Yun Seob SongYun Seob Song More articles by this author , Won Jae YangWon Jae Yang More articles by this author , Sang Hyun CheonSang Hyun Cheon More articles by this author , In Rae ChoIn Rae Cho More articles by this author , Young Deuk ChoiYoung Deuk Choi More articles by this author , and Sung Joon HongSung Joon Hong More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)35438-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1293: Relationship between Prostate-Specific Antigen and Prostate Volume in Korean Men with Benign Prostatic Hyperplasia from Multicenter Study." The Journal of Urology, 173(4S), p. 351 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 351 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Jin Sean Cho More articles by this author Byung Ha Chung More articles by this author Se Joong Kim More articles by this author Young Sig Kim More articles by this author Chun Il Kim More articles by this author Hong Sup Kim More articles by this author Do Hwan Seong More articles by this author Yun Seob Song More articles by this author Won Jae Yang More articles by this author Sang Hyun Cheon More articles by this author In Rae Cho More articles by this author Young Deuk Choi More articles by this author Sung Joon Hong More articles by this author Expand All Advertisement PDF downloadLoading ...
Eradication of Non-T Cell-Inflamed Tumors by in Situ Immunomodulation with PD-L1 Blockade (2020)

Oba, Takaaki MD, PhD; Keler, Tibor PhD; Marsh, Henry C. PhD; Minderman, Hans PhD; Abrams, Scott PhD; Ito, Fumito MD, PhD, FACS Author Information
Monazite Coatings on SiC Fibers II: Oxidation Protection (2006)

The effect of monazite on the oxidation of SiC was studied in laboratory and dry air. Monazite inhibited the oxidation of Tyranno‐SA™, Tyranno‐ZX™, Sylramic, and Hi‐Nicalon SiC fibers. Oxidation of pure chemical vapor deposition SiC and undoped SiC single crystals was not inhibited by monazite. Dry oxidation of both uncoated and monazite‐coated Tyranno‐SA™ fibers initially displayed parabolic kinetics with an activation energy of 180–190 kJ/mol. Subsequently, the oxidation rate of monazite‐coated fibers increased and the oxide‐scale growth rate approached that of the uncoated fibers. No differences in the composition or structure of the silica oxidation product could be detected between uncoated and coated fibers using transmission electron microscopy and energy‐dispersive spectroscopy. Possible mechanisms of the inhibition of SiC oxidation by monazite are discussed.
The Photochemistry of Benzophenone (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Analytical modeling of plasma immersion ion implantation target current using the SPICE circuit simulator (1994)

Plasma immersion ion implantation applies a series of negative high-voltage pulses to a target immersed in a plasma. An analytical model of the currents and potentials induced before, during, and after the negative bias in a planar geometry is presented. The effect of multiple pulses on the results is also studied. The model determines the time-varying ion current, electron current, total current, total dose, and sheath thickness for a piecewise linear voltage pulse. The sheath collapse is found to be important for high repetition rate pulses. Implementation of the model is done in SPICE, a circuit simulator. Comparison with experimental data has demonstrated the accuracy of the model.
Quantitative analysis of split base station processing and determination of advantageous architectures for LTE (2013)

Centralization of the baseband processing in radio access networks may reduce radio site operations costs, reduce capital costs, and ease implementation of multi-site coordination mechanisms such as coordinated multipoint transmission and reception (CoMP). However, the initial architecture proposals for a centralized Long Term Evolution (LTE) deployment using transport of radio samples require a high-bandwidth, low-latency interconnection network. This may be uneconomical, or it may only be cost effective for a limited number of sites. To mitigate that deficiency without sacrificing the benefits of centralized processing, we identified alternative interfacing options between central and remote units. To do so we analyzed possible splits of the Long Term Evolution (LTE) baseband processing chain for their bandwidth and latency requirements. Next, we analyzed the operational impacts of potential splits based on a number of criteria including ease of CoMP introduction, the possibility of realizing pooling gains, and the ability to update the system and introduce new features. Based on our results, we propose architectures that can leverage the benefits of centralization at a much-reduced cost.
A bi-directional communication paradigm between parallel NEURON and an external non-neuron process (2016)

In order to accurately model the pattern of activation due to electrical stimulation of the hippocampus, a multi-scale computational approach is necessary. At the system level, the Admittance Method (ADM) is used to calculate the extracellular voltages created by a stimulating electrode. At the network and cellular levels, a large-scale multi-compartmental neuron network is used to calculate cellular activation. This paper presents a bi-directional communication paradigm between the NEURON model and an external surrogate for the ADM solver, where at each time step, neurons share their membrane currents with the external process, and the external process shares calculated extracellular voltages with the neuronal network. This work constitutes an important first step towards a full multi-scale NEURON-ADM model with bi-directional communication.
Final report: Photochromism as a switching mechanism for electronically active organic materials (1997)

Recent discoveries in the field of conjugated polymers in environmental stability, regiochemical regularity, and electrical conductivity, particularly of polythiophene and polyaniline, have intensified interest in device applications. Present or anticipated applications include development of electrical circuitry on a molecular scale, as well as conducting and semiconducting materials for a variety of applications including thin film transistors and batteries. The authors have investigated a series of compounds comprising conjugated segments coupled to photochromic elements. The photochromic reaction in these compounds reversibly alters the conjugation length and provides a mechanism for switching both the electrical and optical properties of these materials. The authors are currently investigating the nature and scope of this switching mechanism and preparing extended materials that take advantage of this novel form of switching behavior. Preparation and photochromic behavior of several of these materials are described.
Eine Untersuchung kommerzieller Terminverwaltungs-Software im Hinblick auf die Kopplung mit natürlichsprachlichen Systemen (1995)

Das Projekt COSMA (Cooperative Schedule Management Agent) verfolgt das Ziel, einen maschinellen Sekretariatsassistenten zu erstellen, der Termine mit mehreren Teilnehmern über elektronische Post in natürlicher Sprache weitgehend selbständig vereinbart. COSMA stellt natürlichsprachlichen Service für autonome maschinelle Terminplanungs-Agenten zur Verfügung. Eine Anbindung an unterschiedliche kommerzielle Softwareprodukte zur Terminverwaltung könnte die Generalisierbarkeit der in COSMA verfolgten Ansätze nachhaltig plausibel machen.\nIn der hier dokumentierten Untersuchung wurden im Zeitraum März bis Mai 1995 auf dem deutschen Markt befindlichen Produkte untersucht und bewertet. Einige ermöglichen den Zugang zu ihren Termindaten über eine allgemeine Programmierschnittstelle; doch keines stellt Agentenfähigkeit zur Verfügung: Alle Planungs-und Entscheidungsvorgänge bleiben dem Benutzer überlassen. Eine Einbindung in COSMA ist in vielen Fällen technisch möglich, aber erst nach Entwicklung und Einbindung geeigneter Agentensysteme sinnvoll.
Adaptive debiased machine learning using data-driven model selection techniques (2023)

Debiased machine learning estimators for smooth functionals in nonparametric models can exhibit substantial variability and instability, often leading practitioners to instead rely on parametric or semiparametric working models. Such models, however, may be misspecified and can therefore introduce bias. We study how data-driven model selection can be combined with debiased machine learning to construct estimators that adapt to structure in the data-generating distribution. To this end, we propose Adaptive Debiased Machine Learning (ADML), a nonparametric framework for constructing superefficient estimators of pathwise differentiable parameters. The framework unifies a broad class of previously proposed adaptive estimators, including methods based on variable selection, learned feature representations, and collaborative targeted learning. It requires only high-level conditions and approximate validity of the selection procedure, which are implied by lower-level conditions already assumed in important settings, including sieve-based selection, sparsity-based methods such as the Lasso, and data-adaptive feature representations. We show that ADML estimators yield regular and efficient root-\(n\) inference for an oracle projection parameter induced by a data-adaptive oracle submodel. This oracle parameter coincides with the target parameter at the true distribution but typically has a smaller efficiency bound, thereby yielding superefficiency for the target parameter. As a practical illustration, we introduce a broad class of automatic ADML estimators for continuous linear functionals of the outcome regression, in which model selection is performed directly on the regression itself. Motivated by overlap challenges in causal inference, we develop new superefficient plug-in estimators for the average treatment effect based on calibration in semiparametric regression models.
Catalytic synthesis of unsaturated nitriles from NO–alkane or NO–alkene on Pt–Sn/SiO2 (1995)

The Pt–Sn/SiO2 catalysts prepared by selective bimetallic CVD reaction of SnMe4 with Pt particles on SiO2, characterized by EXAFS (extended X-ray absorption fine structure), yield acrylonitrile from NO + propene and methacrylonitrile from NO + isobutene and NO + isobutane with good selectivities, typically 70–93%, in contrast to negligible activity and selectivity (about one order of magnitude lower) with the monometallic Pt/SiO2 catalyst.
Chapter 19. How recent knowledge on furano-specific enzymes has renewed interest for the synthesis of glycofuranosyl-containing conjugates (2014)

International audience