gebhart/patrepeval huggingface dataset:
Increased Fibrosis and Interstitial Fluid Pressure in Two Different Types of Syngeneic Murine Carcinoma Grown in Integrin β3-Subunit Deficient Mice (2012)

Stroma properties affect carcinoma physiology and direct malignant cell development. Here we present data showing that α(V)β(3) expressed by stromal cells is involved in the control of interstitial fluid pressure (IFP), extracellular volume (ECV) and collagen scaffold architecture in experimental murine carcinoma. IFP was elevated and ECV lowered in syngeneic CT26 colon and LM3 mammary carcinomas grown in integrin β(3)-deficient compared to wild-type BALB/c mice. Integrin β(3)-deficiency had no effect on carcinoma growth rate or on vascular morphology and function. Analyses by electron microscopy of carcinomas from integrin β(3)-deficient mice revealed a coarser and denser collagen network compared to carcinomas in wild-type littermates. Collagen fibers were built from heterogeneous and thicker collagen fibrils in carcinomas from integrin β(3)-deficient mice. The fibrotic extracellular matrix (ECM) did not correlate with increased macrophage infiltration in integrin β(3)-deficient mice bearing CT26 tumors, indicating that the fibrotic phenotype was not mediated by increased inflammation. In conclusion, we report that integrin β(3)-deficiency in tumor stroma led to an elevated IFP and lowered ECV that correlated with a more fibrotic ECM, underlining the role of the collagen network for carcinoma physiology.
Tunable Q-Factor Gas-Filled RF Cavity (2018)

Fermilab is the main institution to produce the most powerful and wide-spectrum neutrino beam. From that respective, a radiation robust beam diagnostic system is a critical element in order to maintain the quality of the neutrino beam. Within this context, a novel radiation-resistive beam profile monitor based on a gas-filled RF cavity has been proposed. The goal of this measurement is to study a tunable Q-factor RF cavity to determine the accuracy of the RF signal as a function of the quality factor. Specifically, the measurement error of the Q-factor in the RF calibration is investigated. Then, the RF system will be improved to minimize signal error.
Phosphorus-31 chemical shifts of phosphonate anions (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhosphorus-31 chemical shifts of phosphonate anionsJean G. Riess, John R. Van Wazer, and John H. LetcherCite this: J. Phys. Chem. 1967, 71, 6, 1925–1927Publication Date (Print):May 1, 1967Publication History Published online1 May 2002Published inissue 1 May 1967https://pubs.acs.org/doi/10.1021/j100865a061https://doi.org/10.1021/j100865a061research-articleACS PublicationsRequest reuse permissionsArticle Views244Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Vehicle System Control for Start-Stop Powertrains with Automatic Transmissions (2013)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The 2013 Ford Fusion will be launched with an optional automatic engine start-stop feature. To realize engine start-stop on a vehicle equipped with a conventional powertrain, there are two major challenges in the vehicle system controls. First, the propulsive torque delivery from a stopped engine has to be fast. The vehicle launch delay has to be minimized such that the corporate vehicle attributes can be met. Second, the fuel economy improvement offered by this technology has to justify the cost associated with it. In pursuing fuel economy, the driver's comfort and convenience should be minimally impacted. To tackle these challenges, a vehicle system control strategy has been developed to accurately interpret the driver's intent, monitor the vehicle subsystem's power demands, schedule engine automatic stop and re-start, and coordinate the fast and smooth torque delivery to the wheels. Vehicle tests have shown that the start-stop feature provides a seamless stop-start operation while introducing minimal intrusion to the driving experience. The start-stop technology improves fuel economy by 3.5% on average.&lt;/div&gt;&lt;/div&gt;
A concerted decline in insulin secretion and action occurs across the spectrum of fasting and postchallenge glucose concentrations (2011)

Defects in insulin secretion and action interact with body composition and gender to influence postchallenge glucose concentrations. There is considerable heterogeneity of insulin secretion and action for a given fasting glucose likely because of patient subsets with isolated IFG and normal glucose tolerance.
Anomeric Oxygen to Carbon Rearrangements of Alkynyl Tributylstannane Derivatives of Furanyl (γ)‐ and Pyranyl (δ)‐Lactols. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Economic History of Early Southeast Asia (1993)

In the pre-nineteenth-century world, the Southeast Asian region was eulogized as a land of immense wealth; developments there were of crucial importance to the entirety of world history in the pre-1600 period. Writers, travelers, sailors, merchants, and officials from every continent of the eastern hemisphere knew of Southeast Asia's wealth, and by the second millennium of the Christian era, most were aware of its power and prestige. By contrast, the early history of Southeast Asia and its international significance is not appreciated in the contemporary age.
Materials for receiving, handling, and storing hydrofluoric acid (1971)

The information given in this report can be considered valid for initial design and for cost estimates of equipment to handle most commercial hydrofluoric acids. It is assumed that purchased acid will be received and stored at ambient temperatures. When temperature ranges are not indicated, the data should be considered as valid only for ambient temperatures. Limiting maximum temperatures are given when known. Corrosion rates above these limits are so high that service life may not be economical, or product contamination may be too great. Hydrofluoric acid is available in various concentrations. Anhydrous acid contains small amounts (<200 ppm). Aqueous sacid is less than 80%. This terminology indicates only the commercial ranges of concentration. Although this report is intended as a guide for handling commercial hydrofluoric acids, additional information is given to aid users of HF who encounter dilute strengths. For critical design situations, more specific information may be obtained from acid producers and from suppliers and fabricators of the various materials. Exposure to hydrofluoric acid can cause painful burns and edema of the lungs which often lead to fatalities.
Proteome profiling of spinal cord and dorsal root ganglia in rats with trinitrobenzene sulfonic acid-induced colitis (2012)

TNBS-induced colitis has a profound impact on protein profiling in the nervous system. This result helps understand the neurological pathogenesis of inflammatory bowel disease.
A Flowchart for the Translational Research of CellBased Therapy in the Treatment of Long Bone Defects (2021)

peer reviewed
Expression Levels of a Single Gene, Lymphoid Enhancer Binding Factor 1, Discriminates CLL B-Cells from Other B-Cell Malignancies. (2007)

Abstract B-cell chronic lymphocytic leukemia (CLL), the most common adult leukemia, is a clonal disease manifested by an absolute lymphocytosis. Previously we identified genes capable of sorting and predicting the B-cells of patients with CLL or monoclonal B-cell Lymphocytosis (MBL) from aged matched controls. Using gene expression profiling, we and others have identified genes transcribed at significantly different levels between CLL patients and normal subjects. From these genes RT-QPCR verification was performed, in triplicate or more, on 22 gene candidates. A gene panel of seven genes, significantly different between CLL and normal individuals was chosen: FMOD, CKAP4, PI3Kc2b, LEF1, PFTK1, Bcl2 and GPM6a (in order of Receiver Operating Characteristic [ROC] concordance). This RT-QPCR verification step was based upon the comparison of freshly isolated PBMCs from CLL patients and age matched normal subjects after enriching for B cells with negative selection. The panel was then used to blindly categorize and predict the relationship of RNA from apparently normal subjects, some with and some without MBL, to the mRNA of patients with CLL as well as normal subjects, presumably without MBL. Since the numbers of cells within the expanded clones from individuals with MBL, after positive selection was limiting, RNA was amplified utilizing an RNA whole genome amplification approach and compared to similarly amplified RNA after negative selection; CLL cells, B-cells from normal age matched controls, and cord blood-derived B1 cells, enriched further by CD5 expression with positive selection. Using the Bayesian relevance determination method, a novel computer-learning tool to provide a probabilistic model, 56 samples were identified correctly at the rate of 100%. FMOD and PI3Kc2b were determined to be optimal at predicting blinded samples. In order to make the panel more clinically feasible, a universal reference RNA standard was used as a control, eliminating the need for pairing samples with age-matched controls. Analysis of this new model led to the discovery that a single gene; lymphoid enhancer binding factor 1 (LEF1), was not only capable of sorting CLL B cells from age-matched controls at a 100% rate (n=40) but it was also capable of predicting CLL B cells from other B cell malignancies (n=15). Verification of the protein expression levels for these genes is ongoing. The RNA expression levels of the genes in this panel provides a novel way to identify cell populations and gene expression patterns that change during the transition from B-cell clonal expansions that occur physiologically from those that occur among pre-leukemic and leukemic B-cell populations. The addition of a standard reference RNA enhances the clinical application of this gene panel. These data strongly suggest a unique role for LEF1 in CLL.
Efficiency Enhancement in Hybrid P3HT/Silicon Nanocrystal Solar Cells (2018)

Hybrid organic-inorganic solar cells from poly(3-hexylthiophene) (P3HT) and freestanding silicon nanocrystals (Si-ncs) combine the advantages of silicon-based photovoltaics with the cost-efficient solution processing technique. At present, the microwave-plasma synthesis of Si-ncs that allows for a future upscaling to industrial demands is at the expense of the Si-nc surface quality and the number of charge-trapping defects. Here, we present an enhancement of the solar cell performance by identifying the major factors which are limiting the device efficiency. With the help of low-cost post-growth treatments of the Si-ncs and the optimization of various device parameters, P3HT:Si-ncs bulk heterojunction solar cells with an efficiency up to 1.1% are achieved. In particular, etching of the Si-ncs with hydrofluoric acid to remove the surface oxide shells and surface defects has a strong impact on the solar cell performance. An intermediate Si weight ratio of around 60% is found to lead to the highest current densities. For Si-ncs with very small diameters, an additional enhancement of the open circuit voltage was observed. Moreover, we show that the structural order of P3HT has a strong influence on the efficiency, which can be explained by an improved charge carrier separation at the P3HT/Si-ncs interface in combination with an enhanced charge transport in the P3HT phase.
ChemInform Abstract: Solvent as Catalyst: Computational Studies of Organic Reactions in Solution (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
DEVELOPMENT OF PRML SIMULATOR FOR MAGNETO-OPTICAL DISK SYSTEM (1998)

The Partial-Response Maximum-Likelihood (PRML) signal detection method is well known as an effective way to improve the recording density of a magneto-optical (MO) disk system. We have developed a PRML simulator to evaluate various PRML systems for MO recording. This report presents the performance evaluations of various PRML systems based on computer simulations to find bit error rate (BER) characteristics. Calculation of BER was made under the condition that the wave front aberration caused by tilt of the disk and defocus of the optical head is given to the readout beam.
Bidder Participation and Information in Currency Auctions (2005)

This paper studies the participation and performance of sophisticated versus unsophisticated auction participants in an environment with numerous bidders, uncertainty, and asymmetric information. We examine multi-unit, pay-as-bid, currency auctions conducted by the Central Bank of Venezuela. We find that sophisticated bidders outperform their less sophisticated rivals during periods of high volatility, apparently as a result of their superior informationgathering ability. The result is consistent across both quantity (sophisticated bidders win more market share) and price (sophisticated bidders pay lower premiums). The result is consistent with the view that a pay-as-bid auction format may be detrimental to participation by less-informed bidders.
Human Detection with Range-Doppler Signatures Using 3D Convolutional Neural Networks (2020)

Human detection is proposed based on time-varying range- Doppler signatures measured by millimeter-wave FMCW radar using deep recurrent neural networks. Human detection is a significant topic for security, surveillance, and search and rescue. When a target is measured by fast-chirp FMCW radar, a range-Doppler diagram can be constructed in real time. Because the signatures in a range-Doppler diagram are time-varying, we investigated the feasibility of classifying targets using those signatures. We measured five classes-humans, cars, cyclists, dogs, and road clutter-using millimeter-wave FMCW radar. We applied 3D-convolutional neural networks to 3D representations of time-varying signatures and achieved a classification accuracy of 97%, with a human detection rate of 100%.
Magnetic Detection of Steel Corrosion at a Buried Position Near the Ground Level Using a Magnetic Resistance Sensor (2018)

Corrosion of steel structures, such as lighting and road marker poles, located in close proximity to or buried within the ground have become a social problem. Steel corrosion has been observed to occur rather easily near the ground level. However, corrosion detection in parts of steel structures buried within the ground is very difficult. To address this concern, a magnetic resistance testing system for detecting corrosion in buried steel structures has been developed using a tilted magnetic sensor probe, and it is based on our independently developed extremely low-frequency eddy-current testing methodology. The magnetic sensor probe comprises an anisotropic magnetic resistance sensor, induction coil, and small cancellation coil. The applied magnetic field was operated at extremely low frequencies between 1 and 100 Hz, and the magnetic spectrum, which was traced using the real and imaginary parts of the detected magnetic signal at each frequency, was analyzed for estimating changes in steel thickness. Test samples comprising 4 mm thick stainless steel plates with a partial thinning zone varying in depth between 0.5 and 3.0 mm were used during measurements. Changes in thickness were detected at locations other than the thinning zone by using the differential-magnetic-intensity-subtracted magnetic vector of frequency 1 Hz from that of frequency 20 Hz detected by the tilted magnetic sensor probe. Moreover, the depth of corrosion and its corresponding location beneath the ground level were estimated via measuring techniques involving the use of magnetic sensor probes in the separated position or at different tilt angles in the same position.
Abstract B63: Cancer cell invasion determined by cell density-dependent, cytokine-mediated crosstalk (2013)

Abstract Metastatic spread of cancer cells from their primary site requires invasion into the vasculature, evasion at the distant organ site and colonization of the distant organ. Here we studied mechanisms of attachment and invasion into endothelial monolayers by cancer cells to identify driver molecules and signaling pathways that are crucial for the invasive and metastatic phenotype. In vitro studies were complemented by studies in zebrafish embryos and mouse models of cancer cell invasion and metastasis. In one approach we compared gene expression profiles across isogenic cell lines with distinct invasive behavior to identify candidate drivers and pathways. These were then subjected to functional validation. This comparison of gene expression profiles of isogenic cancer cell lines showed an upregulation of immune response cytokines associated with an endothelial invasive phenotype in human breast cancer cells. The role of the respective cytokine pathways was validated by blocking the respective receptors in in vitro assays and in a zebrafish metastasis model. Citation Format: Ghada M. Sharif, Marcel O. Schmidt, Zhang-Zhi Hu, Eric Glasgow, Anna T. Riegel, Anton Wellstein. Cancer cell invasion determined by cell density-dependent, cytokine-mediated crosstalk. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr B63.
Asphaltenes : fundamentals and applications (1995)

Colloidal Properties of Asphaltenes in Organic Solvents (E.Y. Sheu, D.A. Storm). Sulfur and Nitrogen Molecular Structures in Asphaltenes and Related Materials Quantified by XANES Spectroscopy (O.C. Mullins). Solubility and Phase Behavior of Asphaltenes in Hydrocarbon Solvents (R. Cimino et al.). The Colloidal Nature of Asphaltenes as a Unifying View for the Analyses of Solubility and Interfacial Phenomena (S. Acevedo et al.). The Effects of Asphaltenes on the Chemical and Physical Characteristics of Asphalt (M.S. Lin et al.). Asphalt Emulsion for Environmental Coating and Encapsulation (H. Lian, T.F. Yen). Potential of Ultrasonic Generators for Use in Oil Wells and Heavy Crude Oil/Bitumen Transportation Facilities (M.R. Islam). A New Method of Asphaltic Crude Disposal and Utilization (M.R. Islam). Index.
Development of resist material and process for hp-2x-nm devices using EUV lithography (2010)

Extreme ultraviolet (EUV) lithography is the leading candidate for the manufacture of semiconductor devices at the hp- 22-nm technology node and beyond. The Selete program covers the evaluation of manufacturability for the EUV lithography process. So, we have begun a yield analysis of hp-2x-nm test chips using the EUV1 full-field exposure tool. However, the resist performance does not yet meet the stringent requirements for resolution limit, sensitivity, and line edge roughness. We reported on Selete standard resist 4 (SSR4) at the EUVL Symposium in 2009. Although it has better lithographic performance than SSR3 does, pattern collapse limits the resolution to hp 28 nm. To improve the resolution, we need to optimize the process so as to prevent pattern collapse. An evaluation of SSR4 for the hp-2x-nm generation revealed that a thinner resist and the use of a TBAH solution for the developer were effective in mitigating this problem. Furthermore, the use of an underlayer and an alternative rinse solution increased the exposure latitude by preventing pattern collapse when the resist is overexposed. These optimizations improved the resolution limit to hp 22 nm.
Dual microphone solution for acoustic feedback cancellation for assistive listening (2012)

The method proposed in this paper improves the identification and cancellation of the feedback path by making the adaptive canceller robust against the impact of the desired speech signal. The proposed method allows for the canceller's coefficients to be continuously adapted allowing it to track variations in the feedback path even in the presence of the desired signal. It suggests the use of dual microphones and dual adaptive filters arranged in such a way that allows the speech signal to be identified and removed from the adaptation process. This results in a more robust solution which was verified by our experiments and evaluations. The perceptual evaluation of speech quality (PESQ) measure was also used to show that the proposed method results in better signal quality.
Probiotics for treating eczema (2008)

Evidence suggests that, compared with no probiotic, currently available probiotic strains probably make little or no difference in improving patient-rated eczema symptoms. Probiotics may make little or no difference in QoL for people with eczema nor in investigator-rated eczema severity score (combined with participant scoring for eczema symptoms of itch and sleep loss); for the latter, the observed effect was small and of uncertain clinical significance. Therefore, use of probiotics for the treatment of eczema is currently not evidence-based. This update found no evidence of increased adverse effects with probiotic use during studies, but a separate adverse events search from the first review revealed that probiotic treatment carries a small risk of adverse events.Results show significant, unexplainable heterogeneity between individual trial results. Only a small number of studies measured some outcomes.Future studies should better measure QoL scores and adverse events, and should report on new probiotics. Researchers should also consider studying subgroups of patients (e.g. patients with atopy or food allergies, adults) and standardising doses/concentrations of probiotics given.
<title>Creation of second-order optical nonlinearity in polymer films by photochemical charge injection</title> (1994)

Significant asymmetry and optical nonlinearity (second harmonic generation) can be produced by injection of electric charge into dye/polymer blends. The mechanism for producing the nonlinearity is different from the usual dipolar alignment of the dye in an electrostatic field. Charge injection has been achieved by purely electrical means using `in-plane' electrodes, or photochemically, by irradiating a bilayer structure comprising a photoconductive layer and the polymer/dye layer. This latter technique allows spatial modulation by light of nonlinear optical coefficients.