gebhart/patrepeval huggingface dataset:
Abstract 1840:Nedd9controls glycolysis and autophagy in non-small cell lung cancer (NSCLC) (2019)

Non-small cell lung cancer (NSCLC) has a low survival rate, with metastasis contributing to the vast majority of deaths. Elevated expression of the protein NEDD9 has been reported in a large subset of lung cancers and other malignancies as a promotor of aggressive phenotypes and drug resistance. NEDD9 exerts these pro-metastatic roles by serving as a scaffold for intermediates in the integrin and receptor tyrosine kinase signaling cascades, and other pathways, with NEDD9 knockdown impairing cell migration, motility, and growth. Because scaffolds act by assembling functional complexes in precise stoichiometries, there are cases where both loss and gain result in loss of function. Through analysis of TCGA data, we identified a subset of human NSCLC with low levels of NEDD9 expression, associated with lower overall survival. Therefore, in this study, we for the first time assessed the consequences of a constitutive null genotype for Nedd9 for cancer formation in the 129S/Sv-Krastm3Tyj/Trp53tm1Brn (KP) murine model of NSCLC. Unexpectedly, we found deletion of Nedd9 (in a KPN genotype) significantly accelerated NSCLC tumorigenesis and enhanced tumor invasion. Proteomic analysis of KPN versus KP tumors confirmed these more aggressive phenotypes occurred in spite of depressed activity of the pro-proliferative Nedd9 partners Src and Fak, and surprisingly, suggested depressed expression of activity of enzymes involved in glycolysis in KPN tumors. Functional exploration confirmed a similar protein expression and activity profile, and strongly reduced glycolytic capacity, in multiple human NEDD9-depleted NSCLC cell lines, for the first time demonstrating NEDD9 regulation of glycolysis through control of hexokinase II (HK2) and other enzymes acting upstream of PGK. Compensating for these negative effects of Nedd9 loss during in vivo tumorigenesis, NSCLC tumors arising in KPN mice additionally activated AMPK, causing significantly elevated levels of autophagy, with both aggressive tumor growth and autophagy reduced by the SRC inhibitor dasatinib. Such compensatory activation of autophagy did not occur in cell lines with depleted NEDD9, distinguishing in vitro and in vivo tumor cell signaling response to NEDD9 loss. In sum, these data for the first time identify and define a role for the pro-metastatic protein NEDD9 in control of glycolytic metabolism in NSCLC setting, and establish a mechanism for this control. This data should be useful in guiding selection of patients for specific therapies targeting metabolic pathways.Citation Format: Alexander Y. Deneka, Anna Nikonova, Meghan Kopp, Anna Gaponova, Anna Kiseleva, Harvey Hensley, Erica Golemis. Nedd9 controls glycolysis and autophagy in non-small cell lung cancer (NSCLC) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1840.
Síntesis : curso intermedio de español como lengua extranjera (1995)

This is a complete coursebook for adolescents working towards an intermediate or upper-intermediate level and an exam-preparation coursebook for those aiming to take the Basic Spanish as a Foreign Language Test (Dimploma Basico de Espanol como Lengua Extranjera: DELE). The book is structured into 15 units. Every unit contains the same sections as the DELE test: an introduction to the lesson topic and vocabulary; reading comprehension; grammar and vocabulary; writing; listening comprehension; oral expression; and, notes. There is a review section every 5 lessons. The supplementary material includes the answer key to the exercises.
Information Processing, Information Networking, Cognitive Apparatuses and Sentient Software Systems (2020)

In the physical world, computing processes, message communication networks and cognitive apparatuses are the building blocks of sentient beings. Genes and neural networks provide complementary information processing models that enable execution of mechanisms dealing with “life” using physical, chemical and biological processes. A cognizing agent architecture (mind) provides the orchestration of body and the brain to manage the “life” processes to deal with fluctuations and maintain survival and sustenance. We present a new information processing architecture that enables “digital genes” and “digital neurons” with cognizing agent architecture to design and implement sentient, resilient and intelligent systems in the digital world.
Reducing Relational Database Performance Bottlenecks Using 3D XPoint Storage Technology (2018)

Relational database systems are data-intensive applications because of their heavy I/O workload during a query execution. With more and more data being generated, database sizes are increasing significantly. As a result, database systems incur a tremendous latency to return the query results back to the clients. Using the TPC-H benchmark program, this work explores several key issues that degrade database performance, including read amplification, inefficient use of temporary tables, and higher buffer pool cache miss rates. We show that when clients execute database queries on a conventional storage device, such as a solid-state disk (SSD), the extra I/O latency resulting from the above issues leads to bottlenecks that limit overall database performance. The availability of a new generation storage device, the Optane, which uses a new 3D cross-point technology, provides a feasible approach to accelerate the overall database performance. Processing database queries on this new device produces 1.5-8.3X improvement in the I/O response time, and 1.1-6.5X improvement in the total response time, compared to an SSD-based system.
Methods for monitoring 3-D temperature distributions in power electronic modules (2018)

In this paper, an observer for spatial temperature estimation within power electronic modules is presented. It estimates the junction temperature of the power devices as well as at material interconnects within the power module with high bandwidth. These temperatures can then be monitored to estimate the damage caused by thermomechanical cycling, or even to manipulate cycles by thermal control. The observer is based on a static and dynamic loss model and a transient thermal model. The thermal real time model is derived from a 3-D finite difference model by balanced truncation, such that it can be computed on a conventional digital signal processor. Based on the models and device temperature information, a cascaded observer structure is proposed. It estimates the transient and averaged temperature spatially at various locations of the power module with nearly zero lag, even if the sensor information exhibits delays and has noisy signals. This zero lag, 3-D estimation has not been achieved in prior work Experimental results demonstrate the feasibility and performance of the proposed observer structure.
A scalable halftoning coprocessor architecture (2002)

Exact-angle superscreen dithering requires large dither tiles. Since storing precomputed screen elements for each intensity level would require too much memory, dithering must be executed on the fly at halftoning time. For this purpose a dithering coprocessor is presented which generates halftoned images at high speed. The proposed hardware architecture is based on a pipelined and scalable design which speeds up halftoning by a factor of twenty compared with modern RISC software-based solutions. We describe the architecture of the coprocessor and show to what extent it can be scaled for improving performances. The proposed coprocessor could find applications in digital color copiers which need to print scanned color images at high speed.
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. (2015)

We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct association signals at these loci, including five mapping in or near KCNQ1. 'Credible sets' of the variants most likely to drive each distinct signal mapped predominantly to noncoding sequence, implying that association with T2D is mediated through gene regulation. Credible set variants were enriched for overlap with FOXA2 chromatin immunoprecipitation binding sites in human islet and liver cells, including at MTNR1B, where fine mapping implicated rs10830963 as driving T2D association. We confirmed that the T2D risk allele for this SNP increases FOXA2-bound enhancer activity in islet- and liver-derived cells. We observed allele-specific differences in NEUROD1 binding in islet-derived cells, consistent with evidence that the T2D risk allele increases islet MTNR1B expression. Our study demonstrates how integration of genetic and genomic information can define molecular mechanisms through which variants underlying association signals exert their effects on disease.
Pilot-Based Compensation of Frequency-Selective I/Q Imbalances in Direct-Conversion OFDM Transmitters (2008)

This paper presents a pilot-based compensation algorithm for mitigation of frequency-selective I/Q imbalances in direct-conversion OFDM transmitters. By deploying a feedback loop from RF to baseband, together with a properly-designed pilot signal structure, the I/Q imbalance properties of the transmitter are efficiently estimated in a subcarrier-wise manner. Based on the obtained I/Q imbalance knowledge, the imbalance effects on the actual transmit waveform are then mitigated by baseband pre-distortion acting on the mirror-subcarrier signals. The compensation performance of the proposed structure is analyzed using extensive computer simulations, indicating that very high image rejection ratios can be achieved in practical system set-ups with reasonable pilot signal lengths.
Electrochemical impedance spectroscopy for in situ monitoring of early zeolite formation (2015)

Zeolites are crystalline materials with internal pore structures finding widespread application from everyday products like laundry detergents to large scale catalytic and adsorption processes. Up to today however, zeolite formation is not fully understood. Especially the early stages of zeolite formation remain elusive. Although electrochemical impedance spectroscopy (EIS) has already proven to be a versatile tool for characterization of ionic solutions, it has, to the current knowledge of the authors, never been used before for in situ monitoring of zeolite growth. The linear relation between the measured impedance and Si/OH ratio of clear solutions shows that all added silica in taken out of solution and involved in the formation of nano-aggregates. Electrochemical impedance spectroscopy data for clear solutions has been proven to be complementary with ex situ dynamic light scattering (DLS) and small angle X-ray scattering (SAXS) data and moreover allows for quantitative monitoring of nano-aggregate formation, especially in the crucial early steps where traditional methods fail.
Accumulateurs Lithium-ion et véhicules électriques (2016)

Le comité de pilotage du symposium SGE (..) a pris la décision de reporter le symposium du 6 au 8 Juillet 2021 à la Cité des Congrès à Nantes, au vue de l'évolution actuelle de la pandémie.
Vascular Endothelial Growth Factor-Angiopoietin Chimera With Improved Properties for Therapeutic Angiogenesis (2013)

The VEGF-angiopoietin-1 chimera is a potent angiogenic factor that triggers a novel mode of VEGF receptor-2 activation, promoting less vessel leakiness, less tissue inflammation, and better perfusion in ischemic muscle than VEGF. These properties of VA1 make it an attractive therapeutic tool.
Highly Twisted Donor–Acceptor Boron Emitter and High Triplet Host Material for Highly Efficient Blue Thermally Activated Delayed Fluorescent Device (2019)

New highly efficient thermally activated delayed fluorescence (TADF) dopant materials (PXB-DI and PXB-mIC) for blue organic light-emitting diodes are reported. These materials were designed by combining highly conjugated rigid ring donor moieties and a boron acceptor with a highly twisted configuration to have high TADF performance and minimized self-quenching properties. In addition, a new high triplet energy and hole transport-type host material, 5-(5-(2,4,6-triiso-propylphenyl)pyridin-2-yl)-5 H-benzo[ d]benzo[4,5]imidazo[1,2- a]imidazole (PPBI), is also reported. This host represents deeper blue color owing to keeping the original spectra of emitters. A fabricated blue TADF device with PXB-mIC in the PPBI host exhibited maximum external quantum efficiency (EQE) of 12.5% with a CIE of (0.15, 0.08), which is close to that of the National Television System Committee blue color. The blue TADF device performances of the PPBI host was compared with the electron transport-type 2,8-bis(diphenylphosphine oxide)dibenzofuran (DBFPO) host. The blue TADF device with PXB-DI in the DBFPO host exhibited a maximum EQE of 37.4% in the sky blue region. This study demonstrates that our molecular design concept of new emitters and host is beneficial for future high-efficiency deep-blue TADF devices.
Printed soft skin electrodes for seamless bio-impedance measurements (2023)

Abstract Bio-impedance measurements are widely used to assess various physiological parameters. Contemporary skin electrodes for bio-impedance measurements are cumbersome and novel electrode designs are needed to allow fast and easy placement, long-term stability and user comfort. This investigation introduces dry, printed, bio-compatible electrode arrays, made of screen-printed carbon and inkjet-printed PEDOT:PSS that measure bio-impedance non-invasively and stably. Two contact impedance measurements yield the lowest normalized values of soft electrodes reported to date. Four contact bio-impedance measurements from the radial, ulnar, common carotid and superficial temporal arteries were performed, demonstrating the ability to capture blood pulsation in different areas with small form factor. Owing to the unique properties of the printed electrodes reported here, we were able to demonstrate for the first time blood pulsation in the face, continuous blood pulsation measurement during simultaneous muscle activation and signal stability over many hours.
Affinity, potency, efficacy, and selectivity of neurokinin A analogs at human recombinant NK2 and NK1 receptors (2018)

A series of peptide NK2 receptor agonists was evaluated for affinity, potency, efficacy, and selectivity at human recombinant NK2 and NK1 receptors expressed in CHO cells to identify compounds with the greatest separation between NK2 and NK1 receptor agonist activity. Binding studies were performed using displacement of [125I]-NKA binding to NK2 receptors and displacement of [3H]-Septide binding to NK1 receptors expressed in CHO cells. Functional studies examining the increase in intracellular calcium levels and cyclic AMP stimulation were performed using the same cell lines. A correlation was demonstrated between binding affinities (Ki) and potency to increase intracellular calcium (EC50) for NK2 and NK1 receptors. Ranking compounds by their relative affinity (Ki) or potency (EC50) at NK2 or NK1 receptors indicated that the most selective NK2 agonists tested were [Lys5,MeLeu9,Nle10]-NKA(4-10) (NK1/NK2 Ki ratio = 674; NK1/NK2 EC50 ratio = 105) and [Arg5,MeLeu9,Nle10]-NKA(4-10) (NK1/NK2 Ki ratio = 561; NK1/NK2 EC50 ratio = 70). The endogenous peptide, NKA, lacked selectivity with an NK1/NK2 Ki ratio = 20 and NK1/NK2 EC50 ratio = 1. Of the compounds selected for evaluation in cyclic AMP stimulation assays, [β-Ala8]-NKA(4-10) had the greatest selectivity for activation of NK2 over NK1 receptors (NK1/NK2 EC50 ratio = 244), followed by [Lys5,MeLeu9,Nle10]-NKA(4-10) (ratio = 74), and NKA exhibited marginal selectivity (ratio = 2.8).
Modified Vector Quantization for Small-Cell Access Point Placement with Inter-Cell Interference (2020)

In this paper, we explore the small-cell uplink access point (AP) placement problem in the context of throughput-optimality and provide solutions while taking into consideration inter-cell interference. First, we briefly review the vector quantization (VQ) approach and related single user throughput-optimal formulations for AP placement. Then, we investigate the small-cell case with multiple users and expose the limitations of mean squared error based VQ for solving this problem. While the Lloyd algorithm from the VQ approach is found not to strictly solve the small-cell case, based on the tractability and quality of resulting AP placement, we deem it suitable as a simple and appropriate framework to solve more complicated problems. Accordingly, to minimize ICI and consequently enhance achievable throughput, we design two Lloyd-type algorithms, namely, the Interference Lloyd algorithm and the Inter-AP Lloyd algorithm, both of which incorporate ICI in their distortion functions. Simulation results show that both of the proposed algorithms provide superior 95\%-likely rate over the traditional Lloyd algorithm and the Inter-AP Lloyd algorithm yields a significant increase of up to 36.34\% in achievable rate over the Lloyd algorithm.
High-resolution DUV inspection system for 150-nm generation masks (1999)

In order to perform mask inspection with the high reliability for 150 nm-rule and below devices, the inspection system with high resolution is indispensable. The phase shift masks like DUV HT masks must also be inspected with high sensitivity. A next generation mask inspection system MC-3000 which used DUV optics has been developed, in order to achieve these requirement. The wavelength of this optics is 257 nm that is shorter than that of current UV inspection systems, and is nearly equal to that of current DUV lithography systems. Short wavelength light and high NA optics obtain high resolution, so the defect detection of 130 nm or less is attained. The special issues for the DUV optics were solved by several new techniques. This paper reports the system configuration, basic characteristics for defect detection and inspection performances.
Electron spin resonance studies of the kinetics and mechanism of free radical polymerizations for narrow polydispersity resins (1993)

Electron Spin Resonance (ESR) has been used to study in situ kinetics of a new free radical polymerization process for preparing narrow polydispersity, high molecular weight resins. Initial work has focused on the kinetics and mechanism of initiation. The initiation step is a rate promoted decomposition having, for example, a solution activation energy of 40{+-}5kJ/mole in toluene, compared to 125kJ/mole for thermal decomposition. Computer simulations have been used to numerically solve the reaction kinetics. Initial ESR studies of the kinetics of styrene polymerization, to produce narrow polydispersity resin, are consistent with a proposed mechanism.
The role of accountability in dependable distributed systems (2005)

This paper promotes accountability as a rst-class de-sign principle for dependable network systems. Conven-tional techniques for dependable systems design are insuf-cient to defend against an adversary that manipulates the system covertly in order to lie, cheat, or steal. This paper treats subversion as a form of fault, and suggests that de-signing accountability into the system provides the means to detect, isolate, and tolerate such faults, and even to pre-vent them by removing incentives for malicious behavior. A key challenge for the future is to extend the repertoire of de-pendable systems design and analysis with broadly appli-cable techniques to build systems with target levels of ac-countability quantied by the probability that an attacker will be exposed. 1.
Dispersion Managed L-Band Optical Amplifiers Employing High Gain Per Unit Length Erbium Doped Fiber (2001)

We have developed the EDF whose L-band gain is as high as 1.2dB/m. Combining the newly developed EDF with the conventional one, the dispersion-managed L-band EDFAs have been demonstrated, wherein the dispersion is reduced to 0.2ps/nm.
Radar detection using Siegel distance between autoregressive processes, application to HF and X-band radar (2008)

In this paper, we present an original generalization of the CFAR technique . The technique of CFAR consists in testing two alternative assumptions ldquopresence of targetrdquo versus ldquoabsence of targetrdquo in a distance-azimuth cell called ldquocell under testrdquo. In the case where the noise is Gaussian and additive, one can show that the CFAR is equivalent to withdraw from the signal under test the average of the surrounding signal and to divide the whole by the standard deviation of the surrounding signal. The presence of a target is then decided if the resulting quantity is higher than a given threshold determinated in order to maintain false alarm ratio constant. In our article, the treated data are the In Phase-Quadrature data obtained in each distance-azimuth cell. Those are interesting because their Fourier transform makes one possible to acquire the Doppler spectrum. These data are vectorial and more exactly are regarded as the realization of circular and centered complex Gaussian vectors. In order to generalize the technique of the CFAR, we take into account the works of C. R. Rao in information geometry and the works of T. Ando and D. Petz in order to define the distance between distributions as well as the concept of average. We will decide the presence of a target if the distance from the sample under test to the mean of the surrounding samples is higher than a certain threshold.
High-Temperature Solid Particle Erosion of Environmental and Thermal Barrier Coatings (2023)

Solid particle erosion (SPE) is a common phenomenon observed in gas turbine engines. Particles entrained in the gas flow impact engine hardware, resulting in micro-scale damage that leads to deleterious effects such as material removal. For protective coatings, damage due to SPE is a key concern, since it can negatively affect the durability of the coating and subsequently the life of the underlying component. In this work, the high-temperature SPE behavior of two state-of-the-art environmental barrier coatings (EBCs) deposited via air plasma spray (APS) is investigated using alumina erodent to understand the effect of particle kinetic energy, impingement angle, and temperature. The SPE behavior of the EBCs is also compared to APS and electron beam–physical vapor deposition (EB-PVD) thermal barrier coatings (TBCs) to elucidate similarities and differences in the erosion response. The EBCs were more susceptible to SPE than the EB-PVD TBC but had greater SPE resistance compared to the APS TBC. Coating microstructure and porosity were shown to have a strong influence on the observed behavior.