gebhart/patrepeval huggingface dataset:
Dicopper Complexes with a Dissymmetric Dicompartmental Schiff Base−Oxime Ligand:  Synthesis, Structure, and Magnetic Interactions (1997)

A dicopper(II) complex with an unsymmetrical dicompartmental ligand containing bridging phenolic oxygen atoms was synthesized by stepwise condensation, in the presence of copper(II) ions, of 2,6-diformyl-4-methylphenol and diaminopropane, followed by hydroxylamine. The complex was isolated and characterized as Cl-, [Cu2Cl4]2-, and ClO4- derivatives. A byproduct of the reaction, a copper(II) complex with a substituted salycilaldoxime, was also structurally characterized. The structure of the binuclear cation of major interest is nearly planar, with the copper(II) ions slightly displaced to opposite sides of the plane of the donor atoms (<0.20 Å). [Cu2Cl4]2- is an unusual anion, having been characterized previously in only five other compounds. It is flat, with both copper(I) ions in trigonal planar environments and two chlorides bridging the two copper(I) centers. X-ray structure determinations of the [Cu2Cl4]2- and ClO4- derivatives of the dicopper complex reveal a strong tendency for the formation of coordination dimers and tetramers. These aggregates arise because an oxime oxygen from one binuclear cationic complex coordinates axially to the copper atom of another such complex. In the case of the [Cu2Cl4]2- salt, the anion forms additional bridges between binuclear complexes, resulting in polymeric chains. In the ClO4- salt, however, aggregation is limited to the tetramer because of terminal axially coordinated methanol molecules. Temperature-dependent magnetic susceptibility measurements show strong antiferromagnetic interaction (ca. −700 cm-1) between the two copper(II) ions within one binuclear cationic complex. No magnetic interactions have been observed between binuclear units. Cyclic voltammograms were measured in dimethylformamide (DMF) solution and show two separate reduction waves at −1.47 and −1.04 V, as well as an oxidation wave at +0.04 V (vs Fc+/Fc). The mixed-valent CuII/CuI complex is thermodynamically stable toward disproportionation.
Fermented Oyster Extract Promotes Osteoblast Differentiation by Activating the Wnt/β-Catenin Signaling Pathway, Leading to Bone Formation (2019)

The Pacific oyster, <i>Crassostrea gigas</i>, is well-known as a nutritious food. Recently, we revealed that fermented extract of <i>C. gigas</i> (FO) inhibited ovariectomy-induced osteoporosis, resulting from suppression of osteoclastogenesis. However, since the beneficial effect of FO on osteogenesis is poorly understood, it was examined in mouse preosteoblast MC3T3-E1 cells, human osteosarcoma MG-63 osteoblast-like cells, and zebrafish larvae in this study. We found that FO increased mitochondrial activity from days 1 to 7; however, total cell number of MC3T3-E1 cells gradually decreased without any change in cell viability, which suggests that FO stimulates the differentiation of MC3T3-E1 cells. FO also promoted the expression of osteoblast marker genes, including <i>runt-related transcription factor 2 (mRUNX2)</i>, <i>alkaline phosphatase (mALP)</i>, <i>collagen type I α1 (mCol1α1)</i>, <i>osteocalcin (mOCN)</i>, <i>osterix (mOSX)</i>, <i>bone morphogenetic protein 2 (mBMP2)</i>, and <i>mBMP4</i> in MC3T3-E1 cells accompanied by a significant increase in ALP activity. FO also increased nuclear translocation of RUNX2 and OSX transcription factors, ALP activity, and calcification in vitro along with the upregulated expression of osteoblast-specific marker proteins such as RUNX2, ALP, Col1α1, OCN, OSX, and BMP4. Additionally, FO enhanced bone mineralization (calcein intensity) in zebrafish larvae at 9 days post-fertilization comparable to that in the β-glycerophosphate (GP)-treated group. All the tested osteoblast marker genes, including <i>zRUNX2a</i>, <i>zRUNX2b</i>, <i>zALP</i>, <i>zCol1a1</i>, <i>zOCN</i>, <i>zBMP2</i>, and <i>zBMP4</i>, were also remarkably upregulated in the zebrafish larvae in response to FO. It also promoted tail fin regeneration in adult zebrafish as same as the GP-treated groups. Furthermore, not only FO positively regulate β-catenin expression and Wnt/β-catenin luciferase activity, but pretreatment with a Wnt/β-catenin inhibitor (FH535) also significantly decreased FO-mediated bone mineralization in zebrafish larvae, which indicates that FO-induced osteogenesis depends on the Wnt/β-catenin pathway. Altogether, the current study suggests that the supplemental intake of FO has a beneficial effect on osteogenesis.
Management and Outcomes of Tumor Recurrence After Focal Ablation Renal Therapy (2010)

When a recurrence is suspected after CA or RFA, different options are available. This review has highlighted that active surveillance, reablation, and surgery (usually radical nephrectomy) are all viable options for the management of a failed ablative procedure.
Real-time face blending by automatic facial feature point detection (2008)

We propose a real-time ldquoface blendingrdquo method based on an automatic detection of facial feature points. The method can blend faces of two or more people and generate a morphing-like synthetic image. The proposed method is able to create natural blended images fast. First, fourteen types of facial feature points are detected automatically in both base and texture images. Then the correspondences of the feature points and those of a 3D generic facial shape model are calculated for both images. An intermediate image whose corresponding coordinates for the model are known is generated from the texture image. Finally the blended image is rendered using the generated intermediate image and the base image. The effectiveness of the proposed method is shown through experimental results.
Partial discharge theory and applications to electrical systems (2003)

Partial discharge monitoring is an effective on-line predictive maintenance test for motors and generators at 4160 volt and above, as well as other electrical distribution equipment. The benefits of online testing allow for equipment analysis and diagnostics during normal production. Corrective actions can be planned and implemented, resulting in reduced unscheduled downtime. An understanding of the theory related to partial discharge, and the relationship to early detection of insulation deterioration is required to properly evaluate this predictive maintenance tool. This paper presents a theory to promote the understanding of partial discharge technology, as well as various implementation and measurement techniques that have evolved in the industry. Data interpretation and corrective actions are reviewed, in conjunction with comprehensive predictive maintenance practices that employ partial discharge testing and analysis.
Structure Elucidation, Total Synthesis, Antibacterial In Vivo Efficacy and Biosynthesis Proposal of Myxobacterial Corramycin** (2022)

Herein, we describe the myxobacterial natural product Corramycin isolated from Corallococcus coralloides. The linear peptide structure contains an unprecedented (2R,3S)-γ-N-methyl-β-hydroxy-histidine moiety. Corramycin exhibits anti-Gram-negative activity against Escherichia coli (E. coli) and is taken up via two transporter systems, SbmA and YejABEF. Furthermore, the Corramycin biosynthetic gene cluster (BGC) was identified and a biosynthesis model was proposed involving a 12-modular non-ribosomal peptide synthetase/polyketide synthase. Bioinformatic analysis of the BGC combined with the development of a total synthesis route allowed for the elucidation of the molecule's absolute configuration. Importantly, intravenous administration of 20 mg kg<sup>-1</sup> of Corramycin in an E. coli mouse infection model resulted in 100 % survival of animals without toxic side effects. Corramycin is thus a promising starting point to develop a potent antibacterial drug against hospital-acquired infections.
Evaluation of lung recovery after static administration of three different perfluorocarbons in pigs (2014)

Of the three tested perfluorocarbons, PFOC offered the best tolerance in terms of lung function, gas exchanges and residuum in the lung. PFOC was rapidly cleared from the lungs and virtually disappeared after 4 days whereas PFOB persisted at significant levels and led to foam macrophage infiltration. PFOC could be relevant for short term total liquid ventilation with a rapid weaning.
Pathway Complexity in the Enantioselective Self-Assembly of Functional Carbonyl-Bridged Triarylamine Trisamides (2016)

Functional supramolecular systems like carbonyl-bridged triarylamine (CBT) trisamides are known for their long-range energy transport at room temperature. Understanding the complex self-assembly processes of this system allows for control over generated structures using controlled supramolecular polymerization. Here, we present two novel CBT trisamides with (S)- or (R)-chiral side chains which show a two-pathway self-assembly behavior in solution. Depending on the thermal profile during the self-assembly process, two different stable states are obtained under otherwise identical conditions. A kinetically trapped state A is reached upon cooling to 7 °C, via a proposed isodesmic process. In addition, there is a thermodynamically stable state B at 7 °C that is induced by first undercooling to -5 °C, via a nucleation-elongation mechanism. In both cases, helical supramolecular aggregates comprising H-aggregated CBTs are formed. Additionally, controlled supramolecular polymerization was achieved by mixing the two different states (A and B) from the same enantiomer, leading to a conversion of the kinetically trapped state to the thermodynamically stable state. This process is highly enantioselective, as no conversion is observed if the two states consist of opposite enantiomers. We thus show the importance and opportunities emerging from understanding the pathway complexity of functional supramolecular systems.
Retransmission Timeout Estimation for Low-Delay Applications Using Multipath RTP (2014)

Delay-sensitive media applications typically prioritise timeliness over reliability, therefore preferring UDP over TCP. Retransmission is a method to compensate for packet loss and requires the receiver to provide timely feedback to the sender. Delaying the retransmission request too long may result in the retransmitted media arriving late. Alternatively, aggressive error estimation, where slightly delayed packets are seen as lost, results in unnecessary bandwidth usage and may contribute to further congestion of the network. We study receiver-based retransmission timeout (RTO) estimation in the context of real-time streaming over Multipath RTP and propose a solution in which we use statistical methods to provide accurate RTO prediction which allows for timely feedback. The proposed approach allows the receiver to accurately estimate the RTO when receiving media over multiple paths irrespective of the scheduling algorithm used at the sender. This enables a sender to take advantage of multiple paths for load balancing or bandwidth aggregation by scheduling media based on dynamic path characteristics.
Design and Demonstration of A Compact Full Adder Using Micro-beam Resonators (2018)

In this work, we present the design, analytical and finite element simulations and experimental results of a full adder block using microelectromechanical resonators with multiple split electrodes. The device operation is based on modulating resonance characteristics by the digital DC inputs. The proposed full adder is implemented with only two devices, considerably less complex than standard CMOS designs which require 24 or more transistors. While the current device has a 0.1 kHz speed and energy/operation in pJ, we show that by careful optimization and scaling of the devices, the speed can be increased to MHz and the energy can be reduced to sub-fJ, which shows the potential of this technology for ultra-low power applications with moderate processing requirements. The device is fabricated using silicon-on-insulator wafer with conventional surface micromachining techniques. The implemented circuit is CMOS compatible which allows its monolithic integration with other CMOS-based circuits. The micro-beam resonator operates at room temperature and moderate pressure of 700 mTorr.
Capture, processing, and display of real-world 3D objects using digital holography (2010)

“Digital holography for 3D and 4D real-world objects' capture, processing, and display” (acronym “Real 3D”) is a research project funded under the Information and Communication Technologies theme of the European Commission's Seventh Framework Programme, and brings together nine participants from academia and industry (see www.digitalholography.eu). This three-year project marks the beginning a long-term effort to facilitate the entry of a new technology (digital holography) into the three-dimensional capture and display markets. Its progress at the end of year 2 is summarised.
Femto-second CMOS technology with high-k offset spacer and SiN gate dielectric with oxygen-enriched interface (2003)

We demonstrate 40-nm CMOS transistors for the 70-nm technology node. This transistor uses a high-k offset spacer (EOS: high-epsilon offset spacer) in achieving both a short-channel and high drivability along with SiN gate dielectrics with oxygen-enriched interface (OI-SiN) to suppress both the gate-leakage current and boron penetration. Consequently, N-MOSFET and P-MOSFET have high drive currents of 0.68 and 0.30 mA//spl mu/m, respectively, with I/sub off/=10 nA//spl mu/m, with an EOT value of 1.4 nm. The record gate delay of 280 fs (3.6 THz), for an N-MOSFET with the gate length of 19 nm, has also been achieved.
A study of the younger adult health conditions in Tono area of Gifu prefecture. (1989)

若壮年者 (20～39才) を対象に, 昭和59年から3年間にわたって, 健康診断と生活状態, 家庭歴, 既応歴, 食生活について調査した。高血圧者, 肥満者については, 20才代よりも30才代のが多く, 肝機能異常者, 高尿酸, 脂質異常者は、30才代の男性が多く, 喫煙・飲酒・過食は生活習慣による影響も考えられる。血色素量低下は、女性が高率を示していた。職業では、農業外就労者が男性の80%を占めており, 農夫症は女性の30才代の肩こり、男性の30才代の腰痛が多く, 調査時の自覚症状は気分がイライラするや, 心気症状は女性の30才代に多かった。食習慣については、満腹主義者、高塩分摂取者が男性に多く、甘い物主義者、間食等は女性に多く、牛乳摂取率が27%と低いとは, あまり良い結果ではない。
ChemInform Abstract: Enantioselective Intramolecular Cyclopropanations of Allylic and Homoallylic Diazoacetates and Diazoacetamides Using Chiral Dirhodium( II) Carboxamide Catalysts. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Design and Analysis of A High Specific Power Outer Rotor Surface Mounted Permanent Magnet Machine Equipped with Additively Manufactured Windings (2021)

Electric and hybrid propulsion systems are an important tool to reduce global CO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> emissions especially in aerospace applications. Permanent Magnet (PM) electric motors driving propellers (alone in a pure electric system or in conjunction with the engine in a hybrid system) are considered among the leading candidates in this transformation due to its relatively high Specific Power (SP). In this paper, an outer rotor surface mounted (PM) motor is targeting aerospace hybrid/electric propulsion applications and designed with asymmetrical stator teeth as well as non-uniform turns area for the stator windings. These two design features combines are a result of advancements in Additive Manufacturing (AM) as well as employing non-traditional designs. The proposed design is compared in terms of the electromagnetic performance to an inner-rotor design counterpart as well as another conventional version of the outer-rotor design. Also, a parametric study has been carried out to search for the maximum attenable SP as well as motor efficiency.
A New Coronagraph for NAOS-CONICA -- the Apodising Phase Plate (2010)

In April 2010, a new coronagraphic optical element, called an Apodising Phase Plate (APP), was installed in NAOS-CONICA (NACO). The APP coronagraph is optimised for use at 4.05 ÃÂµm with both narrow- and broadband filters. Unlike other types of coronagraph, it requires no alignment overhead and can be used immediately after switching from direct imaging for observing targets of interest where high contrast is required.
ChemInform Abstract: Continuous‐Flow Synthesis of 3,3‐Disubstituted Oxindoles by a Palladium‐Catalyzed α‐Arylation/Alkylation Sequence. (2011)

Abstract The two‐step synthesis of various methyl‐ and methoxymethyl‐protected oxindoles includes the implementation of a biphasic system with KOH as the base, a palladacycle as the rapidly activated precatalyst, and a packed bed as the microreactor that enables efficient mixing.
1 Adult Neurogenesis: A Prologue (2008)

New ideas pass through a series of stages from initial rejection to skepticism, to reluctant acceptance (without true belief in its importance), to a final casual acknowledgment of the obvious. It is fair to say that the acceptance of the idea that new neurons are generated in the adult brain of all mammals has been a slow process, and along the way, the idea has been met with skepticism and resistance. It is still not yet casually accepted as obvious. Rather, adult neurogenesis remains in the stage of reluctant acceptance, without a clear understanding of its importance, but the search for its function is in full gear. Joseph Altman’s original observations in the 1960s were met with significant reservation, as were attempted confirmations by a handful of investigators in the next 20 years. Somehow, Fernando Nottebohm and Steve Goldman’s observation of neurogenesis in the brains of adult canaries was received more positively but—because it took place in birds—was not considered as much of a threat to the prevailing belief (often even termed “dogma”) that there are no new neurons in the adult mammalian brain. Why this resistance to the capacity of the adult brain to generate new neurons? It was well accepted that other systems, like blood, liver, and skin, could generate new cells, so why not the brain? The most straightforward explanation is that the brain is not just any organ. At a philosophical and metaphysical level, the brain is thought to be the place where the...
Quantitative measurement of complex substances dissolved in an ionic liquid using IR spectroscopy and chemometrics (2016)

Abstract In the past two decades, ionic liquids have found many applications as solvents for complex solutes. Prominent examples are the dissolution of biomass and carbohydrates as well as catalytically active substances. The chemical analysis of such solutions, however, is still a challenge due to the molecular complexity. In the present work, the use of infrared spectroscopy for quantifying the concentration of different solutes dissolved in an imidazolium-based ionic liquid is investigated. Binary solutions of glucose, cellubiose, and Wilkinson's catalyst in 1-ethyl-3-methylimidazolium acetate are studied as examples. For this purpose, different chemometric approaches (principal component analysis (PCA), partial least-squares regression (PLSR), and principal component regression (PCR)) for analyzing the spectra are tested. Principal component analysis was found to be suitable for classifying the different solutions. Both regression techniques were capable of deriving accurate concentration values. The performance of PLSR was slightly better than that of PCR for the same number of components.
One-Step Synthesis of α-Chloro Acetophenones from Acid Chlorides and Aryl Precursors (2007)

A direct and efficient method was developed for the preparation of a variety of substituted acetophenone derivatives from readily available arene precursors and acid chlorides. This method has significant generality and affords access to substitution patterns on aryl rings not directly achievable by Friedel-Crafts chemistry. [reaction: see text].
Multiple release of equimolar amounts of peptides from a polymeric carrier using orthogonal linkage‐cleavage chemistry (1993)

Peptides generated on polymeric beads that are attached to the support via cleavable linkers are released into solution in equimolar amounts in several independent steps and screening of the “peptide libraries” can be performed in the usual manner used for testing peptides in solution.
Composition of component services (2004)

We consider a component to be an encapsulated hardware-software unit that can be used as a building block in the construction of a larger system and that delivers a specified service across a component interface. The problem of composition of a set of components can be broken down into the following two subproblems, the composition of the component services and the incorporation of the components into an integrated software/hardware architecture. We focus on the problem of component service composition
Living Carbocationic Copolymerizations. V. Synthesis of Isobutylene/p-Methylstyrene Copolymers with the Constant Copolymer Composition Technique in the Leidenfrost Reactor (1996)

Abstract Living copolymerization of the isobutylene (IB)-p-methylstyrene (pMeSt) monomer pair in combination with the constant copolymer composition (CCC) technique produces high molecular weight ( M n ≈ 100,000 g·mol−1) and narrow molecular weight distribution ( M w/ M n ≈ 1.45) compositionally uniform IB/pMeSt copolymer molecules in the industrially important IB/pMeSt = 97–99/3–1 mol% composition range. Syntheses were carried out with TiCl4 coinitiator in n-butyl chloride homogeneous solution at −85°C by the use of the Leidenfrost reactor (i.e., by direct cooling of the charge with liquid nitrogen). In order to carry out the CCC technique it was necessary to obtain reliable copolymerization reactivity ratios. These investigations led to rIB = 0.5 ± 0.1 and r pMeSt = 10 ± 4. The attainment of CCC and living copolymerization conditions has been quantitatively demonstrated by dedicated diagnostic plots. Specifically, the attainment of CCC conditions was proven by the analysis of composite rate plots (comonomers input and corresponding copolymer formed versus time) and composition plots (comonomer composition in feed and copolymer formed versus weight of copolymer formed, W p), and living copolymerization was proven by linearly ascending number-average molecular weight of copolymer ( M n) versus W p plots starting at the origin.
Validation of diffuse optical tomography using a bi-functional optical-MRI contrast agent and a hybrid MRI-DOT system (2013)

Since diffuse optical tomography (DOT) is a low spatial resolution modality, it is desirable to validate its quantitative accuracy with another well-established imaging modality, such as magnetic resonance imaging (MRI). In this work, we have used a polymer based bi-functional MRI-optical contrast agent (Gd-DTPA-polylysine-IR800) in collaboration with GE Global Research. This multi-modality contrast agent provided not only co-localization but also the same kinetics, to cross-validate two imaging modalities. Bi-functional agents are injected to the rats and pharmacokinetics at the bladder are recovered using both optical and MR imaging. DOT results are validated using MRI results as "gold standard"
RECENT STATUS OF THE NIRS CYCLOTRON FACILITY (2007)

Several modifications and improvements in the NIRS-930 cyclotron have been performed in past fiscal year later on 2005 to early of 2007. One of the most important in them was to replace the RF-system including Dee-electrodes, resonator, power-amplifier, and its control system. In the present the new RF-system can be provided the maximum frequency up to 21.4MHz, that covers an acceleration of proton energy of 90 MeV, and the system is successfully used. At the same time another beam extraction channel was installed in the cyclotron to extraction of a high beam current by mean of charge exchange. Almost 100% of extraction efficiency for 40MeV of H + beam had been obtained at an extraction channel. Meanwhile another new beam line has been constructed for the vertically irradiation to solid-targets.