gebhart/patrepeval huggingface dataset:
Author response: Primed Track, high-fidelity lineage tracing in mouse pre-implantation embryos using primed conversion of photoconvertible proteins (2018)

Primed Track is an image analysis tool that allows for computational correction of drifting specimen to enable accurate lineage tracing of mammalian pre-implantation development even for larger imaging time intervals.
A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system (2017)

While the immune system is essential for the maintenance of the homeostasis, health and survival of humans, aberrant immune responses can lead to chronic inflammatory and autoimmune disorders. Pharmacological modulation of drug targets in the immune system to ameliorate disease also carry a risk of immunosuppression that could lead to adverse outcomes. Therefore, it is important to understand the 'immune fingerprint' of novel therapeutics as they relate to current and, clinically used immunological therapies to better understand their potential therapeutic benefit as well as immunosuppressive ability that might lead to adverse events such as infection risks and cancer. Since the mechanistic investigation of pharmacological modulators in a drug discovery setting is largely compound- and mechanism-centric but not comprehensive in terms of immune system impact, we developed a human tissue based functional assay platform to evaluate the impact of pharmacological modulators on a range of innate and adaptive immune functions. Here, we demonstrate that it is possible to generate a qualitative and quantitative immune system impact of pharmacological modulators, which might help better understand and predict the benefit-risk profiles of these compounds in the treatment of immune disorders.
Power-Management Architecture of the Intel Microarchitecture Code-Named Sandy Bridge (2012)

Modern microprocessors are evolving into system-on-a-chip designs with high integration levels, catering to ever-shrinking form factors. Portability without compromising performance is a driving market need. An architectural approach that's adaptive to and cognizant of workload behavior and platform physical constraints is indispensable to meeting these performance and efficiency goals. This article describes power-management innovations introduced on Intel's Sandy Bridge microprocessor.
Preparation of Low Invasive Type Glucose Sensor for Continuous Glucose Monitoring (2020)

Implantable glucose sensors for a continuous glucose monitoring (CGM) system are getting more attractive, since it not only provide an instant glucose value but also its continuous value trend, which help to provide an effective medical treatment. However, the current commercialized or presented conventional CGM sensor devise are required to have about an length of 1.0 cm to be inserted inside the skin. Therefore, it is desirable to develop a lower invasive type glucose sensor to improve the quality of life of diabetic patients. We have previously proposed an unique glucose sensor, which has a sensing region at the tip of a fine tapered needle. Therefore, it only require a short tip of the sensor devise to be implanted to perform as an CGMS sensor. We attempted to implant this sensor device for a length of 1.0 mm in the skin, and the glucose monitoring was performed. As a result, we could obtain sensor response, which had a good correlation with blood glucose value trend. This result indicate that the glucose measurement in a lighter region than subcutaneous tissue, which might be in dermis, may also provide valuable information for diabetes patients’ blood glucose management. Nevertheless, low-invasive sensor, which is essential with miniaturization of sensing region, leads to a decrease of glucose response current. Therefore, the improvement of sensor sensitivity is also indispensable. In this study, we prepared glucose sensors in various procedures to develop a sensor with high sensor sensitivity.
Solution and solid state13C NMR and X-ray studies of genistein complexes with amines. Potential biological function of the C-7, C-5, and C-4′-OH groups (2003)

Parent genistein and its new amine complexes with morpholine and piperazine were studied comparatively in the solid and liquid states by X-ray crystallography and 13C and 15N NMR spectroscopy. Biochanine A and its complexes were used as reference. Secondary deuterium isotope effects on 13C chemical shifts in solution were studied in parent isoflavones and their morpholine and piperazine complexes to aid in evaluation of the electronic distribution in both systems. In addition, to quantify the extent of proton transfer as well as to establish strong hydrogen bonding of the 7-OH group in a morpholine complex, proton transfer from the 7-OH group to the piperazine nitrogen atom was also confirmed by 13C NMR in the solid state and by X-ray studies. The effect of 7-OH deprotonation yields a high frequency shift of 7-8 ppm on the C-7 carbon atom of the piperazine complex whereas it is as large as 12 ppm in the morpholine complex in the solid. The former trend is confirmed from solution state concentration studies which also show that the isoflavones have a strong tendency to form complexes with bases. Depending on the pKa difference between the isoflavones and the base this leads either to proton transfer and ion-pair formation or, in the case of a larger pKa difference, to a hydrogen bonded ion pair. The concentration studies show formation of a 1:1 genistein-piperazine complex in DMSO. Addition of water leads to formation of solvent separated ions. The C-5 OH group is involved in strong intramolecular hydrogen bonding leading to a pseudo aromatic ring extending the aromatic part of the drug pharmacophore. The analysis also suggests the way that both the C-7 and C-4' hydroxyl group of genistein may participate in stabilising the ternary inhibitor complexes of tyrosine-specific kinases or DNA topoisomerase II.
21.2 km graded-index v.a.d. fibre with low loss and wide bandwidth (1980)

A 21.2 km graded-index optical fibre has been fabricated by the v.a.d. method. Special attention was paid to the temperature distribution on the growing surface of the porous preform to obtain the desired refractive-index profile. In the 21.2 km fibre, the transmission loss and 6 dB down bandwidth achieved were 0.64 dB/km and 57 MHz at 1.3 μm, respectively.
Multiqubit logic gates in NMR quantum computing (2000)

Much of the current understanding of logic gates for quantum computation relies on the application of one- and two-qubit gates in order to implement a universal set of logic gates, as well as other gates. Such ideas stem from the notion that the Hamiltonians available for quantum computation are one or two-body processes. However, present day NMR implementations of quantum information processing (QIP) rely on the internal Hamiltonian of a liquid state system in which there are many two-body processes that occur simultaneously. Such use of the internal Hamiltonian allows for the creation of `multiqubit' logic gates, i.e. logic gates that operate on many qubits simultaneously and are more efficient than a sequence of one- and two-qubit rotations that effect the same operation. Such larger qubit operations offer a universal set of gates (even when not all couplings within the internal Hamiltonian are readily accessible) as well as more convenient and efficient implementations of the Hadamard transform, the controlled-NOT gate, and a quantum Fourier transform that scales linearly (assuming all couplings can be turned on and off at will).
The Relationships between Survivals and Early Salvage Androgen Deprivation Therapy for Non-Organ Confined Prostate Cancer after Radical Prostatectomy (2020)

Androgen deprivation therapy (ADT) is one salvage treatment used when prostate-specific antigen (PSA) recurs after radical prostatectomy (RP), especially in high-risk prostate cancer (PC) patients. However, the optimal timing for salvage ADT (SADT) is still unclear. In this study, we analyzed the efficacy of early SADT for non-organ confined PC. We investigated pathologically confirmed, non-organ confined PC patients who received SADT for PSA recurrence after RP. Patients with distant metastasis, those with lymph node involvement confirmed by lymph node dissection, and those who received neo-adjuvant or adjuvant therapy were excluded. Early SADT was defined as ADT initiated before PSA levels reached 0.5 ng/ml from the nadir PSA level after RP. Univariable and multivariable Cox regression analyses were performed for distant metastasis-free, PC-specific, and overall survival. Data from 345 patients were analyzed. The median follow-up duration was 82 months. The median PSA level was 10.9 ng/ml. Patients with T3b or T4 stage cancers represented 24.9% of the cohort; those with a Gleason score ≥9 represented 15.1%. The 10-year distant metastasis-free survival, PC-specific survival and overall survival were 87.1%, 92.0%, 80.9%, respectively. In univariable and multivariable Cox regression analyses, SADT that was initiated when PSA levels were less than 0.5 ng/mL was significantly associated with improved distant metastasis-free survival, PC-specific survival, and overall survival in non-organ confined PC. Early SADT initiated in patients with PSA levels <0.5 ng/mL was associated with increased distant metastasis-free survival, PC-specific survival, and overall survival in non-organ confined PC after RP.
Stability and bias stressing of metal/insulator/metal diodes (2010)

The performance and stability of metal/insulator/metal tunnel diodes was investigated as a function of interfacial roughness using Al, Ir, Pt, and ultra-smooth amorphous multi-metal (ZrCuAlNi) bottom electrodes with uniform Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> tunnel dielectrics deposited via atomic layer deposition. Current density versus field behavior and device yield were found to be a function of interfacial roughness with smoother electrodes exhibiting more ideal behavior and higher percentages of working devices. A preliminary investigation of DC bias stressed devices suggests that interfacial roughness plays a large role in stability and reliability as well.
Beyond Fitts' law (1997)

Article Free Access Share on Beyond Fitts' law: models for trajectory-based HCI tasks Authors: Johnny Accot Centre d'Études de la, Navigation Aérienne, 7 avenue Edouard Belin, 31055 Toulouse cedex, France and Input Research Group, CSRI, University of Toronto, Toronto, ON M5S 1A4, Canada Centre d'Études de la, Navigation Aérienne, 7 avenue Edouard Belin, 31055 Toulouse cedex, France and Input Research Group, CSRI, University of Toronto, Toronto, ON M5S 1A4, CanadaView Profile , Shumin Zhai Input Research Group, CSRI, University of Toronto, Toronto, ON M5S 1A4, Canada and IBM Almaden, Research Center, 650 Harry Road, San Jose, CA Input Research Group, CSRI, University of Toronto, Toronto, ON M5S 1A4, Canada and IBM Almaden, Research Center, 650 Harry Road, San Jose, CAView Profile Authors Info & Claims CHI '97: Proceedings of the ACM SIGCHI Conference on Human factors in computing systemsMarch 1997 Pages 295–302https://doi.org/10.1145/258549.258760Published:27 March 1997Publication History 328citation6,971DownloadsMetricsTotal Citations328Total Downloads6,971Last 12 Months602Last 6 weeks96 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Compact Optomechanical Phase Shifter for Visible Light Integrated Photonics (2018)

This paper reports on the development of a CMOS compatible capacitively actuated optomechanical phase shifter for visible light, demonstrated on a 200mm PECVD SiN photonic platform. The phase shifting was demonstrated using Mach-Zehnder interferometers.
Electrospinning of high-performance co-polyimide nanofibers (2013)

Co-polyimide nanofibers based on BPDA (3, 3′, 4, 4′-Biphenyltetracarboxylic dianhydride)/PDA (p-Phenylene-diamine)/ODA (4, 4′-Oxydianiline) are fabricated through electrospinning and imidization from its precursor polyamic acid (PAA). The resulting nanofiber bundles show high Young's moduli and tensile strengths of 38±0.3 GPa and 1630±15 MPa, respectively.
Control Barrier Functions With Unmodeled Dynamics Using Integral Quadratic Constraints (2021)

This paper presents a control design method that achieves safety for systems with unmodeled dynamics at the plant input. The proposed method combines control barrier functions (CBFs) and integral quadratic constraints (IQCs). Simplified, low-order models are often used in the design of the controller. Parasitic, unmodeled dynamics (e.g. actuator dynamics, time delays, etc) can lead to safety violations. The proposed method bounds the input-output behavior of these unmodeled dynamics in the time-domain using an alpha-IQC. The alpha-IQC is then incorporated into the CBF constraint to ensure safety. The approach is demonstrated with a simple example.
Indolo-naphthyridine-6,13-dione thiophene building block for conjugated polymer electronics: Molecular origin of ultrahigh n-type mobility (Conference Presentation) (2017)

We present the synthesis and characterization of four conjugated polymers containing a novel chromophore for organic electronics based on an indigoid structure. These polymers exhibit extremely small band gaps of ∼1.2 eV, impressive crystallinity, and extremely high n-type mobility exceeding 3 cm2 V s–1. The n-type charge carrier mobility can be correlated with the remarkably high crystallinity along the polymer backbone having a correlation length in excess of 20 nm. Theoretical analysis reveals that the novel polymers have highly rigid nonplanar geometries demonstrating that backbone planarity is not a prerequisite for either narrow band gap materials or ultrahigh mobilities. Furthermore, the variation in backbone crystallinity is dependent on the choice of comonomer. We find that electron mobility can be correlated to the degree of order along the conjugated polymer backbone. Finally, we use this novel system to begin to understand the complicated effect of alkyl chain variation on the solid state packing in all 3 dimensions.
Single-Pixel Polarimetric Detection and Discrimination in Cluttered Media (2007)

This study consists on the exploitation of enhanced target detection and efficient discrimination techniques utilizing novel experimental techniques, based on single-pixel polarimetric detection. The experimental results of this study indicate that enhanced target detection and discrimination can be obtained, in a variety of scenarios, by utilizing advanced single-detection polarimetric techniques combined with ultra-low noise detection techniques.
Application of the combined FibroMeter vibration‐controlled transient elastography algorithm in Chinese patients with non‐alcoholic fatty liver disease (2016)

Liver stiffness measurement alone can confidently exclude significant and advanced fibrosis in NAFLD patients. Using FM VCTE in patients with high liver stiffness can increase the positive predictive value to rule in F2-4 and F3-4.
Gender and End-User Computing (2011)

Although gender differences in a technological world are receiving significant research attention, much of the research and practice has aimed at how society and education can impact the successes and retention of female computer science professionals. The possibility of gender issues within software, however, has received almost no attention, nor has the population of female end users. However, there is relevant foundational research suggesting that gender-related factors within a software environment that supports end-user computing may have a strong impact on how effective male and female end users can be in that environment. Thus, in this article, we summarize theory-establishing results from other domains that point toward the formation of grounded hypotheses for studying gender differences in end-user computing. There has been much background research relevant to human issues of end-user computing, which we define here as problem-solving using computer software, also termed end-user programming in some of the literature (e.g., Blackwell, 2002; Green & Petre, 1996; Nardi, 1993). (See the glossary for definitions of these and related terms.) Despite this, few researchers have considered potential gender HCI issues and gender differences that may need to be accounted for in designing end-user computing environments. The most notable exception is Czerwinski’s pioneering research on the support of both genders in navigating through 3-D environments (Czerwinski, Tan, & Robertson, 2002; Tan, Czerwinski, & Robertson, 2003). Although individual differences, such as experience, cognitive style, and spatial ability, are likely to vary more than differences between gender groups, evidence from Czerwinski’s work as well as work in other domains, such as psychology and marketing, has found gender differences relevant to computer usage. In fact, some research has shown that some software is (unintentionally) designed for males (Huff, 2002). One reason gender HCI issues in end-user computing are important is that ignorance of gender issues has already proven to be dangerous: today’s low percentage of computer science females (Camp, 1997) has been directly attributed to the past unawareness of gender issues in computer science education and in the workforce. There is a risk that if gender HCI issues in end-user computing environments are ignored, a similar phenomenon could occur with female end users. Request access from your librarian to read this chapter's full text.
Persistence of Pulmonary Hypertension in Patients undergoing Ventricular Assist Devices and Orthotopic Heart Transplantation (2022)

Abstract Background Pulmonary hypertension (PH) is common in advanced heart failure which exhibits short-term improvement after left ventricular assist device (VAD) implantation or orthotopic heart transplantation (OHT), but long-term effects remain unknown. This study evaluated PH persistence after VAD as destination therapy (VAD-DT), bridge to transplant (VAD-BTT), or OHT-alone. Methods A retrospective review of patients who underwent VAD-DT (n=164), VAD-BTT (n=111), or OHT-alone (n= 138) at a single tertiary-care center. Right heart catheterization (RHC) data was collected pre-, post-intervention (VAD and/or OHT), and 1-year from final intervention (latest-RHC) to evaluate the longitudinal hemodynamic course of right ventricular (RV) function and PH. PH (Group-II and Group-I) definitions were adapted from expert guidelines. Results All groups showed significant improvements in mean pulmonary artery pressure (mPAP), pulmonary artery wedge pressure (PAWP), cardiac output (CO), and pulmonary vascular resistance (PVR) at each RHC with greatest improvement at post-intervention RHC (Post-VAD or Post-OHT). PH proportion reduced from 98% to 26% in VAD-BTT, 92% to 49% VAD-DT, and 76% to 28% from pre-intervention to latest-RHC. At latest-RHC mPAP remained elevated in all groups despite normalization of PAWP and PVR. VAD-supported patients exhibited suppressed pulmonary artery pulsatility index (PaPi&lt; 3.7) with improvement only post-transplant at latest-RHC alongside improved right atrial pressures (RAP). Furthermore, post-transplant with PH at latest-RHC (n=60) exhibited lower survival (HR: 2.1 [95%CI: 1.3-3.4], p&lt;0.001). Conclusion Despite an overall significant improvement in pulmonary pressures and PH proportion, a notable subset of patients exhibited residual RV derangements and PH persistence post-intervention. This post-intervention PH impacted post-transplant survival. Condensed Abstract This study evaluates the longitudinal hemodynamic course of right ventricular (RV) function associated with heart-failure-related Pulmonary Hypertension (PH) and the impact of advanced interventions such as ventricular assist device and/or orthotopic heart transplant on PH persistence. Patients undergoing advanced interventions exhibit differences in PH prevalence which are dependent on the intervention received. Our results highlight despite an overall improvement in pulmonary pressures and PH, a notable number of patients exhibit RV dysfunction consistent with persistent PH. Furthermore, the persistence of PH after successful cardiac transplantation in a subset of patients continues to impact mortality in the long-term.
cFLIP critically modulates apoptotic resistance in epithelial-to-mesenchymal transition (2017)

Epithelial cancers (carcinomas) comprise the top four causes of cancer-related deaths in the United States. While overall survival has been steadily improving, therapy-resistant disease continues to present a major therapeutic challenge. Carcinomas often exploit the normal developmental program, epithelial-to-mesenchymal transition (EMT), to gain a mesenchymal phenotype associated with increased invasiveness and resistance to apoptosis. We have previously shown that an isoxazole-based small molecule, ML327, partially reverses TGF-β-induced EMT in an immortalized mouse mammary epithelial cell line. Herein, we demonstrate that ML327 reverses much of the EMT gene expression program in cultured carcinoma cell lines. The reversal of EMT sensitizes these cancer cells to the apoptosis-inducing ligand TRAIL. This sensitization is independent of E-cadherin expression and rather relies on the downregulation of a major anti-apoptotic protein, cFLIP<sub>S</sub>. Loss of cFLIP<sub>S</sub> is sufficient to overcome resistance to TRAIL and exogenous overexpression of cFLIP<sub>S</sub> restores resistance to TRAIL-induced apoptosis despite EMT reversal with ML327. In summary, we have utilized an isoxazole-based small molecule that partially reverses EMT in carcinoma cells to demonstrate that cFLIP<sub>S</sub> critically regulates the apoptosis resistance phenotype associated with EMT.
A83 NOVEL ANTIPSYCHOTIC WITH DOPAMINE ANTAGONISM AND GABAERGIC ACTIVITY (2005)

1BioLineRx, Ltd., Jerusalem, Israel 2Department of Chemistry, Bar Ilan University, Ramat Gan, Israel 3Felsenstein Medical Research Center, Tel Aviv University Medical School Beilinson Campus, Petach Tikva, Israel Abstracts of the 11th Biennial EBPS Meeting
Predictive data locality optimization for higher-order tensor computations (2021)

Automating locality optimization is still an open problem for compiler writers. Compiler-based approaches, guided by analytical cost models have achieved some success in matching high performance libraries on a restricted set of computations such as general matrix multiply (GEMM). On the other hand, library-based approaches may present some open scalability concerns. Recent developments in convolutional neural networks has seen an explosion of models, each with differing combinations of parameters. Manually tuning each of these configurations can take many development months. Further, these operations are called multiple times during machine learning training, which necessitates highly optimized implementations. 2D convolutional operators are unique in that they consist of 7-deep loop nests with different loops carrying reuse for different tensors, making the problem of identifying an optimal loop ordering hard. We devise a machine learning-based compiler which learns a regression model, correlating performance with the loop order. We integrate this model with other traditional compiler analysis for transformations such as loop unrolling and vectorization, relying on the MultiLevel Intermediate Representation (MLIR) compiler framework. We achieve an average speedup of 1.67x and 1.41x against oneDNN for 2D convolution forward and weight update kernels respectively. We are also at 0.88x and 0.96x the performance of oneDNN's best performing implementation which applies additional data layout transformations.