gebhart/patrepeval huggingface dataset:
ENDOR Studies of l-Arginine and NG-Hydroxy-l-Arginine Bound to All Three Holo-Nitric Oxide Synthase Isozymes  [J. Am. Chem. Soc. 2000, 122, 5405−5406]. (2000)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionENDOR Studies of l-Arginine and NG-Hydroxy-l-Arginine Bound to All Three Holo-Nitric Oxide Synthase Isozymes [J. Am. Chem. Soc.2000, 122, 5405−5406].David L. Tierney, Hui Huang, Pavel Martásek, Linda J. Roman, Richard B. Silverman, Bettie Sue Siler Masters, and Brian M. HoffmanCite this: J. Am. Chem. Soc. 2000, 122, 38, 9352Publication Date (Web):September 6, 2000Publication History Published online6 September 2000Published inissue 1 September 2000https://pubs.acs.org/doi/10.1021/ja004658ohttps://doi.org/10.1021/ja004658ocorrectionACS PublicationsCopyright © 2000 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views299Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (11 KB) Get e-Alertsclose Get e-Alerts
A data-driven approach to stochastic network optimization (2016)

This paper considers the long-term network resource allocation problem subject to queue stability. The dynamic problem is first reformulated as a static stochastic programming. To tackle the resultant static programming, we study its dual problem which contains finite number of variables in oppose to the primal problem that has infinite dimension. A novel online framework is developed by formulating the dual stochastic optimization as empirical risk minimization. We first propose an offline scheme for batch training which linearly converges to the optimal dual argument in expectation. The offline approach is further extended to the online setting which successfully converges to the statistical accuracy of the adaptive training set with high probability. It is both theoretically and numerically established that the novel approach can significantly improve delay and convergence of existing network optimization schemes.
The Chennai Pediatric Electrophysiology Symposium (TCPES 2010) Septal Accessory Pathway: Anatomy, Causes for Difficulty, and an Approach to Ablation (2010)

Accessory pathway (AP) ablation is one of the most satisfying invasive electrophysiology procedures associated with high success rates and relatively few complications. Nevertheless, when APs are found on the cardiac septum, ablative procedures become complex, and unique pitfalls need to be avoided. These difficulties with septal ablation are magnified in the pediatric population. The relatively small heart, rapid nodal conduction, and proximity of the arterial system specifically complicate septal ablation in children. The electrophysiologist must use every tool in his or her armamentarium, including exact delineation of pathway location, identification of pathway potentials, detection of the presence of pathway slant, etc. In addition, an exact knowledge of the complex anatomy of the cardiac septum, including the posteroseptal space, the aortic cusp region, and the proximity of the AV conduction system and coronary vessels, becomes mandatory. In this review, we describe the developmental anatomy and regional anatomy of septal accessory pathways. We then discuss approaches to map specific to pathways in particularly problematic regions at or near the septum, including venous and aortic cusp related accessory pathways.
Lithium‐ion Batteries and Supercapacitors for Use in Hybrid Electric Vehicles (2013)

This chapter demonstrates that the use of ionic liquids (ILs) as electrolyte components of lithium-ion batteries and supercapacitors is a powerful strategy to develop systems for power assist in full hybrid electric vehicles (HEVs). ILs are more difficult to ignite than the conventional solvents; hence, in batteries, the former increase safety and are beneficial to the evolution of a large battery market. In electrochemical double-layer carbon supercapacitors (EDLCs), ILs of wide electrochemical stability are allowed to reach high cell voltages and high specific energies, which make supercapacitors potential competitors with lithium-ion batteries for power-assisted HEVs, with the added advantage of inherently higher safety and cycle life. Therefore, whereas in batteries the use of ILs mainly promotes safety, in supercapacitors such use also demonstrates a great advantage in terms of energy.
Generalized Cuckoo Hashing with a Stash, Revisited (2020)

Cuckoo hashing is a common hashing technique, guaranteeing constant-time lookups in the worst case. Adding a stash was proposed by Kirsch, Mitzenmacher, and Wieder at SICOMP 2010, as a way to reduce the probability of failure (i.e., the probability that a valid Cuckoo assignment fails to exist). It has since become a standard technique in areas such as cryptography, where a negligible probability of failure is often required. We focus on an extension of Cuckoo hashing that allows multiple items per bucket, which improves the load factor. That extension was also analyzed by Kirsch \emph{et al.} in the presence of a stash. In particular, letting $d$ be the number of items per bucket, and $s$ be the stash size, Kirsch \emph{et al.} showed that, for constant $d$ and $s$, the failure probability is $\mathcal{O}(n^{(s+1)(1-d)})$. In this paper, we first report a bug in the analysis by Kirsch \emph{et al.} by showing a counter-example leading to an asymptotically-larger probability of failure $Ω(n^{-d-s-1})$. Then we provide a general analysis and upper bound of the failure probability for (almost) arbitrary $d$ and $s$, instead of just constant, which is useful for applications in cryptography. We finally deduce from the general analysis a tight bound $Θ(n^{-d-s})$ for the probability of failure, for constants $d$ and $s$.
Single-mode fiber with segmented core (1983)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text V. A. Bhagavatula and P. E. Blaszyk, "Single-mode fiber with segmented core," in Optical Fiber Communication, OSA Technical Digest (Optica Publishing Group, 1983), paper MF5. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Dynamic Relative Gain Array Estimation using Local Polynomial Approximation Approach (2016)

This article presents a procedure that utilizes the local polynomial approximation approach in the estimation of the Dynamic Relative Gain Array (DRGA) matrix and its uncertainty bounds for weakly nonlinear systems. This procedure offers enhanced frequency resolution and noise reduction when random excitation is used. It also allows separation of nonlinear distortions with shorter measuring time when multisine excitation is imposed. The procedure is illustrated using the well-known quadruple tank process as a case study in simulation and in real life. Besides, a comparison with the pairing results of the static RGA, nonlinear RGA and DRGA based on linearized quadruple tank model for different simulation cases is performed.
High seroprevalence but short-lived immune response to SARS-CoV-2 infection in Paris (2020)

ABSTRACT Although the COVID-19 pandemic peaked in March/April 2020 in France, the prevalence of infection is barely known. Herein, we assessed using high-throughput methods the serological response against the SARS-CoV-2 virus of 1847 participants working in one institution in Paris. In May-July 2020, 11% (95% CI: 9.7-12.6) of serums were positive for IgG against the SARS-CoV-2 N and S proteins and 9.5% (CI:8.2-11.0) were pseudo-neutralizer. The prevalence of immunization was 11.6% (CI:10.2-13.2) considering positivity in at least one assays. In 5% (CI:3.9-7.1) of RT-qPCR positive individuals, no systemic IgGs were detected. Among immune individuals, 21% had been asymptomatic. Anosmia and ageusia occurred in 52% of the IgG-positive individuals and in 3% of the negative ones. In contrast, 30% of the anosmia-ageusia cases were seronegative suggesting that the true prevalence of infection may reach 16.6%. In sera obtained 4-8 weeks after the first sampling anti-N and anti-S IgG titers and pseudo-neutralization activity declined by 31%, 17% and 53%, respectively with half-life of 35, 87 and 28 days, respectively. The population studied is representative of active workers in Paris. The short lifespan of the serological systemic responses suggests an underestimation the true prevalence of infection.
Post-placement residual-overlap removal with minimal movement (1999)

In this paper we present a novel approach for removing residual overlaps among blocks. We start out by representing the placement in the sequence pair form and describe transformations to the sequence pair to make the placement feasible. This is followed by a distance-based slack allocation to generate a new placement with no overlaps, while being as close to the original placement as possible. Our results demonstrate the efficacy of our approach in transforming layouts with overlaps to overlap-free layouts with minimal object movement.
Sub-pJ operation of broadband asymmetric Fabry–Perot all-optical gate with coupled cavity structure (1998)

We report on all-optical gating characteristics of a novel low-temperature-grown asymmetric Fabry–Perot (AFP) device, in which improvement of performance with respect to conventional AFP all-optical switches is achieved by a short and coupled cavity configuration. Sub-pJ (∼800 fJ) operation is realized with a high contrast ratio (&amp;gt;10 dB) over a broad wavelength range (∼7 nm). Even for 250 fJ pump pulses, a contrast ratio of &amp;gt;6 dB is obtained over a 4 nm wavelength range.
An adaptive, asymptomatic SARS-CoV-2 workforce screening program providing real-time, actionable monitoring of the COVID-19 pandemic (2022)

COVID-19 remains a challenge worldwide, and testing of asymptomatic individuals remains critical to pandemic control measures. Starting March 2020, a total of 7497 hospital employees were tested at least weekly for SARS CoV-2; the cumulative incidence of asymptomatic infections was 5.64%. Consistently over a 14-month period half of COVID-19 infections (414 of 820, total) were detected through the asymptomatic screening program, a third of whom never developed any symptoms during follow-up. Prompt detection and isolation of these cases substantially reduced the risk of potential workplace and outside of workplace transmission. COVID-19 vaccinations of the workforce were initiated in December 2020. Twenty-one individuals tested positive after being fully vaccinated (3.9 per 1000 vaccinated). Most (61.9%) remained asymptomatic and in majority (75%) the virus could not be sequenced due to low template RNA levels in swab samples. Further routine testing of vaccinated asymptomatic employees was stopped and will be redeployed if needed; routine testing for those not vaccinated continues. Asymptomatic SARS-CoV-2 testing, as a part of enhanced screening, monitors local dynamics of the COVID-19 pandemic and can provide valuable data to assess the ongoing impact of COVID-19 vaccination and SARS-CoV-2 variants, inform risk mitigation, and guide adaptive, operational planning including titration of screening strategies over time, based on infection risk modifiers such as vaccination.
ChemInform Abstract: SYNTHESIS OF 9‐METHOXY‐1,6‐DIAZAPHENALENE (1983)

Abstract Die aus dem 2‐Chinolon (I) durch Nitrierung hergestellte Nitroverbindung (II) wird durch Behandlung mit Phosphoroxychlorid und anschließende Reduktionin das Amin (IV) übergeführt, dessen Dianion mit Kohlendioxid, Schwefelkohlenstoff oder Benzoesäureethylester zum tricyclischen Diazaphenalensystem cyclisiert.
Updated results from the phase III ALTTO trial (BIG 2-06; NCCTG (Alliance) N063D) comparing one year of anti-HER2 therapy with lapatinib alone (L), trastuzumab alone (T), their sequence (T→L) or their combination (L+T) in the adjuvant treatment of HER2-positive early breast cancer. (2017)

502 Background: Pre-specified 5-year analyses of the phase III Adjuvant Lapatinib and/or Trastuzumab Treatment Optimisation (ALTTO) Trial defined in Amendments 11&amp;12. Methods: From June 2007 to July 2011, 8381 patients (pts) were randomised from 946 sites in 44 countries to receive either L+T, T→L, L, or T. In 2011, due to futility the L arm was closed and is not included in this analysis. The primary end point is disease-free survival (DFS). Secondary objectives include treatment comparisons with respect to overall survival (OS), time to recurrence (TTR), time to distant recurrence (TDR), cardiac and overall safety and tolerability. Primary analysis results of the study were published in JCO 2015 34:1034-1042. This updated analysis occurs at a 6.9 yrs median follow up (MFU). Results: All patients have reached 5-years of follow-up. 705 DFS events for L+T vs T have been observed. HR for DFS was 0.86 (95% CI, 0.74-1.00; 6-yr DFS%=85% vs 82%) for L+T vs T and 0.93 (95% CI, 0.81-1.08; 6-yr DFS%=84% vs 82%) for T→L vs. T. The 6-year OS was 93%, 92%, and 91% for L+T, T→L, and T, respectively. HR for OS was 0.86 (95% CI, 0.70-1.06) for L+T vs. T and 0.88 (95% CI, 0.71-1.08) for T→L vs. T. DFS differences for L+T vs. T were slightly higher for the hormone-receptor(ER)-negative [HR 0.80 (95% CI, 0.64-1.00; 6-yr DFS%=84% vs. 80%)] and the sequential chemotherapy [HR 0.83 (95% CI, 0.69-1.00; 6-yr DFS%=83% vs.79%)] subgroups. There were no differences in sites of first DFS events according to treatment arm for CNS, loco-regional, or distant recurrences. There were more AEs related to study treatment (L+T 93% vs T 64%). The incidence of primary cardiac end points was low: 1% for L+T, 0.5% for T→L and 0.9% for T. Conclusions: The HRs for this updated analysis are similar to those from the Primary Analysis and the event rate remains lower than anticipated (705 vs 850 planned). Cardiac toxicity remains low. This analysis suggests that HER2+/ER- tumors may have a different biology than HER2+/ER+ and may benefit more from dual HER2 blockade. Long-term follow up continues. Clinical trial information: NCT00490139.
Use of Bioluminescent Imaging to Assay the Transplantation of Immortalized Human Fetal Hepatocytes into Mice (2008)

Noninvasive serial monitoring of the fate of transplanted cells would be invaluable to evaluate the potential therapeutic use of human hepatocyte transplantation. Therefore, we assessed the feasibility of bioluminescent imaging using double or triple fusion lentiviral vectors in a NOD-SCID mouse model transplanted with immortalized human fetal hepatocytes. Lentiviral vectors driven by the CMV promoter were constructed carrying reporter genes: firefly luciferase and green fluorescence protein with or without herpes simplex virus type 1 thymidine kinase. Human fetal hepatocytes immortalized by telomerase reconstitution (FH-hTERT) were successfully transduced with either of these fusion vectors. Two million stably transduced cells selected by fluorescence-activated cell sorting were injected into the spleens of NOD-SCID mice pretreated with methylcholanthrene and monocrotaline. The transplanted mice were serially imaged with a bioluminescence charged-coupled device camera after D-luciferin injection. Bioluminescence signal intensity was highest on day 3 (6.10 +/- 2.02 x 10(5) p/s/cm2/sr, mean +/- SEM), but decreased to 2.26 +/- 1.54 x 10(5) and 7.47 +/- 3.09 x 10(4) p/s/cm2/sr on day 7 and 10, respectively (p = 0.001). ELISA for human albumin in mice sera showed that levels were similar to those of control mice on day 2 (3.25 +/- 0.92 vs. 2.84 +/- 0.59 ng/ml, mean +/- SEM), peaked at 18.04 +/- 3.11 ng/ml on day 7, and decreased to 8.93 +/- 1.40 and 3.54 +/- 0.87 ng/ml on day 14 and 21, respectively (p = 0.02). Real-time quantitative RT-PCR showed gene expression levels of human albumin, alpha1-antitrypsin, and transferrin in mouse liver were 60.7 +/- 6.5%, 26.0 +/- 1.4%, and 156.8 +/- 62.4% of those of primary human adult hepatocytes, respectively, and immunohistochemistry revealed cells with human albumin and alpha1-antitrypsin expression in the mouse liver. In conclusion, our study demonstrated that bioluminescent imaging appears to be a sensitive, noninvasive modality for serial monitoring of transplanted hepatic stem cells.
ChemInform Abstract: A Short Stereoselective Synthesis of (±)‐Carpamic Acid. (1986)

Abstract Gemäß Formelschema erhält man die im Titel genannte Verbindung (V) ausgehend von Methylacetoacetat (I) und Crotylbromid (II).
Multi-user MIMO (2013)

With MIMO based on spatial division multiplexing (SDM) in 802.11n, one device transmits multiple data streams to another device. With the inclusion of downlink multi-user MIMO (DL MU-MIMO) in 802.11ac, an access point (AP) simultaneously transmits independent data streams to multiple client devices. Consider the example illustrated in Figure 14.1, with an AP and two client devices. In the example the AP has four antennas, one client device has two antennas (device A in Figure 14.1), and the other client device has one antenna (device B in Figure 14.1). An AP can simultaneously transmit two data streams to device A and one data stream to device B.
Analysis of PLL clock jitter in high-speed serial links. (2003)

We analyze the effects of transmitter and receiver phased-locked loop (PLL) phase noise, which translates to time-domain clock/data jitter, on the performance of high-speed transceivers. Analytical expressions are derived to incorporate both transmitter and receiver clock jitter into serial link operation. A method to calculate the worst-case noise margin degradation due to clock jitter is discussed in order to obviate impractical time-domain simulations. This analysis relies on the assumption that the channel is linear and time-invariant and, hence, can be characterized by an impulse response. A simple extension to equalized serial links is also presented. The analysis is verified through behavioral simulations using a realistic/measured channel model.
A Ferroelectric-Capacitor-Based Approach to Quasistatic Electric Field Sensing (2009)

A new sensor for quasistatic electric field (E-field) measurements based on a ferroelectric capacitor (which acts as a nonlinear active dynamic element) is discussed in this paper. The device was theoretically modeled and experimentally characterized, and the data that were gathered were used to refine the model parameters. The E-field sensing strategy is based on the exploitation of a mechanism to convert the external target E-field into a perturbation on the polarization state of a ferroelectric material: a detailed analytical description of this process is given together with its experimental validation. Optimal results have been obtained with a driving (i.e., reference) signal of 10 V at 100 Hz, which was used to polarize the device. The noise floor of the device has been evaluated through an analysis of the power spectral density, which yields a value of 0.4 (V/m)/Hz <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1/2</sup> . The hysteretic capacitor in this paper is the cornerstone of an innovative system for detecting weak E-fields (assumed to be dc throughout this paper, although it can also be applied to detect time-periodic E-fields) through the exploitation of the nonlinear behavior of a coupled oscillator system wherein the active (nonlinear) elements are the ferroelectric capacitors. Our results cover the basic building blocks that were necessary for the optimal realization of this coupled circuit.
Influence of the Chemical Structure of Functional Monomers on Their Adhesive Performance (2008)

Functional monomers in adhesive systems can improve bonding by enhancing wetting and demineralization, and by chemical bonding to calcium. This study tested the hypothesis that small changes in the chemical structure of functional monomers may improve their bonding effectiveness. Three experimental phosphonate monomers (HAEPA, EAEPA, and MAEPA), with slightly different chemical structures, and 10-MDP (control) were evaluated. Adhesive performance was determined in terms of microtensile bond strength of 4 cements that differed only for the functional monomer. Based on the Adhesion-Decalcification concept, the chemical bonding potential was assessed by atomic absorption spectrophotometry of the dissolution rate of the calcium salt of the functional monomers. High bond strength of the adhesive cement corresponded to low dissolution rate of the calcium salt of the respective functional monomer. The latter is according to the Adhesion-Decalcification concept, suggestive of a high chemical bonding capacity. We conclude that the adhesive performance of an adhesive material depends on the chemical structure of the functional monomer.
Subjective assessment of consumer video summarization (2006)

The immediate availability of a vast amount of multimedia content has created a growing need for improvements in the field of content analysis and summarization. While researchers have been rapidly making contributions and improvements to the field, we must never forget that content analysis and summarization themselves are not the user's goals. Users' primary interests fall into one of two categories; they normally either want to be entertained or want to be informed (or both). Summarization is therefore just another tool for improving the entertainment value or the information gathering value of the video watching experience. In this paper, we first explore the relationship between the viewer, the interface, and the summarization algorithms. Through an understanding of the user's goals and concerns, we present means for measuring the success of the summarization tools. Guidelines for the successful use of summarization in consumer video devices are also discussed.
N-process synchronization by 4.log2N-valued shared variable (1980)

The problem of implementing mutual exclusion of N asynchronous parallel processes in a model where the primitive communication mechanism is a test-and-set operation on a shared variable, was the subject of extensive research. While a two-valued variable suffices to insure mutual exclusion, it is shown in [1] that N/2 values are necessary to avoid lockout of any process, and N + 1 values are required to insure bounded waiting time. We introduce the idea of employing randomization in the synchronization protocol and achieve a mutual exclusion, lockout-free, bounded-waiting solution using just 4(log2N+4)-valued shared variable. The protocol is extremely simple, easy to implement, and avoids certain undesirable features present in some of the other solutions.