gebhart/patrepeval huggingface dataset:
Bioconjugated Fluorescent Zeolite L Nanocrystals as Labels in Protein Microarrays (2011)

Zeolite L nanocrystals, as inorganic host material containing hydrophobic fluorophore N,N'-bis(2,6-dimethylphenyl)perylene-3,4,9,10-tetracarboxylic diimide in the unidirectional channels, are developed as new labels for biosensor systems. The external surface of the particles is modified with carboxylic acid groups for conjugation to primary amines of biomolecules such as antibodies. Anti-digoxigenin (anti-DIG) is selected to be immobilized on zeolite L via N-hydroxysulfosuccinimide ester linker. Together with DIG, it serves as a good universal binding pair for diverse analyte detection owing to the high binding affinity and low background noise. The conjugates are characterized by the dynamic light scattering technique for their hydrodynamic diameters and by enzyme-linked immunosorbent assay for antigen-antibody binding behavior. The characterizations prove that anti-DIG antibodies are successfully immobilized on zeolite L with their binding activities maintained. The microarray fluorescent sandwich immunoassay based on such nanocrystalline labels shows high sensitivity in a thyroid-stimulating hormone assay with the lower detection limit down to the femtomolar range. These new fluorescent labels possess great potential for in vitro diagnostics applications.
Products from Basidiomycetes (1997)

The chapter contains sections titled: Introduction Cultivation of Basidiomycetes Primary and Secondary Metabolites from Basidiomycetes—Biosyntheses and Possible Functions Screening Methods Used for the Detection of Potentially Useful Metabolites Bioactive Metabolites from Basidiomycetes Future Perspectives
Surface treatment effects on the thickness dependence of the remanent polarization of PbZr0.52Ti0.48O3 capacitors (2003)

In this letter, we report on the thickness dependence of the remanent polarization of Pt/PbZr0.52Ti0.48O3/SrRuO3 capacitors. Two different patterning techniques were used to fabricate the capacitors. For lift-off processed capacitors, the remanent polarization decreased with decreasing thickness. Ion-beam-etched capacitors, however, showed a constant remanent polarization for all PbZr0.52Ti0.48O3 film thicknesses down to 23 nm. Remarkably, this constant remanent polarization for ion-beam-etched capacitors corresponds to the spontaneous polarization expected for a stress-free bulk PbZr0.52Ti0.48O3 crystal.
Characteristics ofthegetter materials used inHigh Intensity DischargeLamps (2006)

Inthefield ofdischarge lampsmanyefforts are focused onimproving qualities andperformances ofthedevices. Itiswellknownthatgaseous impurities, possibly present inside theburner andinside theouter bulbofHighIntensity Discharge (HID)lamps, areoneofthemaincauses ofthedeterioration of their performances. Usually getter materials areadopted toabsorbthegaseous impurities thatmay begenerated by theresidues oflamp fabrication process orthatarereleased during lampoperation. Thesecanbeefficiently removedbymeansofasimple getter component, so as to createand maintain theveryclean atmosphere necessary toassure highquality characteristics ofthe lampforallitslife. Getters areusedinHID lampswithouter bulbsbothundervacuumandwithnitrogen atmosphere; inthis secondtypeoflampsitisnecessary thatthegetter works properly without being affected by,orinterfering with, thejacket filling gas.Thegetter material mustbeabletosorbvarious gaseous species generated inside thelampenvelope, suchas hydrogen, watervapour, carbon monoxide andhydrocarbons. Inthis paperwewill present anddiscuss properties andsorption characteristics ofthemaingetter materials adopted inHID lamps, suchastheZr-Al, Zr-FeandZr-Co-Rare Earths alloys. Thesorption performances ofthematerials weremeasured in experimental systemssimulating possible lampconditions. Experiments werecarried outtostudy theability ofthematerials to capturehydrogen thatisthemostdeleterious gaseous contaminant indischarge lamps. Moreover, in orderto understand thecomplexsorption mechanisms thattakeplace onthegetters whendifferent gaseous impurities arecoexisting inside thelamps, specific tests were performed todetermine thesimultaneous sorption ofdifferent gasspecies, suchassorption ofhydrogen andnitrogen, hydrogen andcarbonmonoxide, hydrogen andcarbon dioxide.
Pegvisomant, a Growth Hormone-Specific Antagonist, Undergoes Cellular Internalization (2004)

GH binding to a receptor (GHR) dimer triggers signaling and internalization of the receptor/ligand complex. Pegvisomant is a specific GH antagonist developed for the treatment of acromegaly, and the basic molecule is GH with an amino acid substitution that blocks the conformational change necessary to generate functional GHR dimerization required for signal transduction. Pegvisomant has additional polyethylene glycol moieties to prolong its half-life in the circulation and improve clinical efficacy through reduced renal clearance. Pegvisomant has a long plasma half-life, and its mode of clearance has not been established. We have studied pegvisomant internalization and demonstrate that despite its size and prolonged plasma half-life, it is internalized by cells expressing the GHR. As pegvisomant does not activate intracellular signal transduction systems, our results support the concept that the conformational changes required for GHR signaling are not essential for the intracellular trafficking of the ligand and establish one potential contributing mechanism for pegvisomant clearance.
A statistical model for synthesis of detailed facial geometry (2006)

Figure 1: Synthesis of facial detail.(a) We begin with a low-resolution mesh obtained from a commercial scanner.( b) Then, we synthesize detail on it using statistics extracted from high-resolution meshes in our database.(c) Finally, we age the face by adjusting the statistics to match those of an elderly man.Note that all figures in this paper use Exaggerated Shading [Rusinkiewicz et al. 2006] to emphasize small geometric details.
Cytokine interactions in human immunodeficiency virus-infected individuals: roles of interleukin (IL)-2, IL-12, and IL-15. (1995)

Cytokines have been shown to be powerful regulators of the immune response. In this study, we analyze the effect that the newly recognized cytokine interleukin (IL)-15 has on proliferation and cytokine induction using peripheral blood mononuclear cells (PBMCs) and purified CD4+ T cells from patients infected with human immunodeficiency virus (HIV) who are at various stages in their disease. We observed that IL-15 enhances the proliferative response in a dose-dependent manner from PBMCs of HIV-infected individuals when stimulated by polyclonal mitogen, tetanus toxoid, or HIV-specific antigen. The effects of exogenous IL-15 are substantially diminished by adding a neutralizing antibody to the beta chain of the IL-2 receptor. Moreover, the ability of IL-15 to increase proliferation is enhanced by the presence of endogenous IL-2 produced in the cultures. The effect that exogenous IL-15 had on IL-2, IL-4, and interferon (IFN)-gamma induction from PBMC's or CD4+ T cells in response to mitogen or tetanus toxoid was also examined. This was compared to the effect that exogenous IL-2 and IL-12 had under the same conditions. Addition of IL-2 or IL-15 to short-term in vitro cultures of either PBMCs or CD4+ T cells had little effect on IL-2, IL-4, or IFN-gamma production. By contrast, IL-12 caused substantial enhancement of both IL-2 and IFN-gamma production from these cultures. The role that endogenous cytokines have on IFN-gamma induction was also studied. Addition of a neutralizing antibody to the alpha chain of the IL-2 receptor or IL-12 to antigen stimulated cultures caused a striking decrease in IFN-gamma production. Neutralization of endogenous IL-15 also resulted in diminished IFN-gamma production from cultures stimulated with mitogen. IL-4 and IFN-gamma protein production by PBMCs and CD4+ T cells stimulated with mitogen was assessed to see if we could detect a specific bias of cytokine production. Small amounts of IL-4 were detected from CD4+ T cells but not PBMCs from most individuals tested. IFN-gamma and IL-2, however, were also produced from these same cultures. These results further elucidate the mechanism of cytokine regulation in HIV-infected individuals, and they provide evidence that IL-15 may be a useful immune modulator.
TWEAK and Fn14 expression in the pathogenesis of joint inflammation and bone erosion in rheumatoid arthritis (2011)

The expression of TWEAK by CD22+ B cells and CD38+ plasma cells in RA synovium represents a novel potential pathogenic pathway. High levels of sTWEAK in active RA synovial fluid and of TWEAK and Fn14 in active RA tissue, together with the effect of TWEAK to induce osteoblastic RANKL expression, is consistent with TWEAK/Fn14 signalling being important in the pathogenesis of inflammation and bone erosion in RA.
In-service monitoring of PMD induced optical signal degradation using SOP vector trajectory on the Poincare Sphere for high-speed reconfigurable optical networks (2009)

We studied an in-service signal quality estimation method by using wavelength resolved SOP vector trajectories on Poincare Sphere and successfully distinguished PMD induced signal degradation with sufficient accuracy from the other signal degradation factors.
Configuration space impedance control for continuum manipulators (2015)

Despite their intrinsic structural compliance, a safe interaction of continuum robots with their environment requires a control strategy that is able to manage the compliant motion properly. This paper presents a peculiar strategy of application of the impedance control based on kinematic and dynamic models of the manipulator's sections. The control approach is able to deal with unpredicted contacts which can occur in unknown locations along the whole manipulator while the resulting contact forces don't need to be measured or estimated. The control concept is applied to a single section of the Bionic Handling Assistant, but its application can be extended to all the continuum robots modeled with the piecewise constant curvature approach.
Activation of PPARγ prevents ferroptosis-induced damage through Nrf2/Gpx4 signaling pathway in rat hippocampus following epilepsy (2023)

Wang, Ming-Jian; Liu, Xue; Chi, Song; Wang, Fei-Yu; Zhang, Liang; Yao, Min-Yi; Liu, Tao; Gao, Jing Author Information
Studies on the Role of Nitrogen in the Feed for Fischer-Tropsch Synthesis Under Fixed-Bed Reactor System (2015)

In this study, Co/Al203 catalyst for Fischer-Tropsch synthesis was prepared via slurry impregnation method and the catalyst was characterized by various techniques such as TPR, XRD, TGA and N2 physisorption. To dissolve the wax, after-reaction catalyst was dewaxed using n-Hexane at 60 *C. The experiments were performed in a bench-scale fixed-bed reactor, under the reaction condition of 230 degrees C, 20 bar and feed volume ratio of H2:CO:N2 = 2:1:0.5-1.5. The methane selectivity and the ratio of olefin to paraffin among C2-C4 hydrocarbons were increased with higher contents of nitrogen in feed gas which result in higher partial pressure ratio of H2 to CO, and also affect methane selectivity which has a significant role in increased CO conversion.
P‐175: Profile of Heterostructured Host for Phosphorescent OLED and its Application to the White Lighting Devices with Low Driving Voltage (2011)

Abstract The electrophosphorescent OLED with heterostructured (mixed) light emission layer was characterized. Base on the best combination profile of mixed emitter obtained, we have fabricated the white OLEDs, where the selective cross‐patterning technique was employed for the spatial variation of emitting layer thickness. The corresponding lower driving voltage and stable color characteristics were investigated.
Progress on the Microwave-Assisted Recycling of Spent Lithium Battery Graphite (2023)

The robust development of electric vehicles has driven a surging decommission stream of lithium-ion batteries (LIBs) owing to their limited service life. The recycling of spent LIBs has become an urgent and essential task for the sustainable development of the LIB industry. However, the prevailing recycling methods focus only on recycling valuable metal, whilst the graphite anode materials are usually discarded or burned as fuels, leading to great waste of valuable carbon material. A facile strategy to obtain value-added products in an efficient manner is of great significance for the recycling of spent graphite. As graphite has excellent microwave absorption capability and electrical conductivity, microwave radiation on spent graphite can induce a Joule heat–discharge–plasma coupled effect, leading to a rapid heating process, especially when discharge occurs, exhibiting a thermal shock effect with the generation of a large number of high-energy electrons and active materials. This special feature facilitates microwave heating that is tailored for assisting the removal of impurities, structure repair, and graphite intercalation and exfoliation in an efficient manner. Therefore, different from the conventional graphite recycling route that is associated with energy/solution-intensive processes, this paper reviews the progress on microwave-assisted removal of impurities, repair of damaged graphite structure, and innovatively discusses the breakthroughs in microwave-assisted preparation of graphite intercalation compounds, expanded graphite, graphene and graphene-based materials, and porous graphene, with an aim to provide a scientific reference for the value-added resource utilization of spent graphite and preparation of new energy storage materials.
EPR of a defect in CVD diamond involving both silicon and hydrogen that shows preferential alignment (2010)

A defect involving both silicon and hydrogen has been characterized using multifrequency electron paramagnetic resonance. The defect, denoted WAR3, was observed in a single-crystal chemical-vapor deposition diamond, which was homoepitaxially grown on a {110}-oriented substrate and doped with isotopically enriched silicon (90% $^{29}\text{S}\text{i}$). The obtained data are explained by a silicon divacancy structure which is decorated by a hydrogen atom and is in the neutral charge state, ${({\text{Si-V}}_{2}:\text{H})}^{0}$ $(S=\frac{1}{2})$. The experimentally derived $^{29}\text{S}\text{i}$ and $^{1}\text{H}$ hyperfine parameters are in agreement with values calculated using the spin-density-functional technique, ruling out a nonplanar structure. Defects are usually randomly oriented such that there is an equal probability for the symmetry axis of the defect to lie along each of the crystallographically equivalent directions. However, the WAR3 defect shows preferential alignment with respect to the {110} growth plane of the sample. Approximately four times as many WAR3 centers were aligned with their mirror planes lying perpendicular to the growth plane, compared to a statistical distribution. This indicates that the majority of WAR3 defects grew in as units rather than by the diffusion and aggregation of constituents. Analysis of the increase in the WAR3 concentration and the decrease in preferential alignment upon annealing the sample at $1400\text{ }\ifmmode^\circ\else\textdegree\fi{}\text{C}$ shows that WAR3 can also be created post growth.
Platelet derived growth factor receptor alpha mediates nodal metastases in papillary thyroid cancer by driving the epithelial-mesenchymal transition (2016)

Recently platelet derived growth factor receptor-alpha (PDGFRα) was recognized as a potential target to treat aggressive papillary thyroid cancer given its strong association with lymph node metastases. However, it is unclear how PDGFRα potentiates metastases and if it works through the canonical MAPK pathway traditionally linked to PTC oncogenesis. We explored the phenotypic changes driven by PDGFRα activation in human papillary thyroid cancer (PTC) cells and the downstream signalling cascades through which they are effected. We demonstrate that PDGFRα drives an impressive phenotypic change in PTC cell lines as documented by significant cytoskeletal rearrangement, increased migratory potential, and the formation of invadopodia. Cells lacking PDGFRα formed compact and dense spheroids, whereas cells expressing active PDGFRα exhibited invadopodia in three-dimensional culture. To achieve this, active PDGFRα provoked downstream activation of the MAPK/Erk, PI3K/Akt and STAT3 pathways. We further confirmed the role of PDGFRα as a transformative agent promoting the epithelial to mesenchymal transition of PTC cells, through the augmentation of Snail and Slug expression. Crenolanib, a small molecule inhibitor of PDGFRα, suppressed the levels of Snail and Slug and almost completely reversed all the phenotypic changes. We demonstrate that PDGFRα activation is an essential component that drives aggressiveness in PTC cells, and that the signaling pathways are complex, involving not only the MAPK/Erk but also the PI3K/Akt and STAT3 pathways. This argues for upstream targeting of the PDGFRα given the redundancy of oncogenic pathways in PTC, especially in patients whose tumors over-express this tyrosine kinase receptor.
Atkins、Zone、Ornish和LEARN饮食对超重绝经前女性体重改变及相关危险因素影响的比较:一项随机试验(A～Z减肥研究) (2007)

背景:大众化饮食,尤其是低碳水化合物饮食,向当前所提倡的低脂高碳水化合物饮食的减肥推荐方案提出了挑战,但其可能的获益和风险尚未得到充分验证。目的:比较4种代表由低至高水平碳水化合物摄入的减肥饮食对体重减轻及相关代谢变量的影响。设计、机构和参与者:2003年2月至2005年10月间在美国开展一项为期12个月的随机化试验,纳入311例生活自主、超重/肥胖(体重指数27～40)、无糖尿病的绝经前女性。
ChemInform Abstract: Addition of Olefins to Aromatic Ketones Catalyzed by Rh(I) Olefin Complexes. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
321: No Differences in Biochemical Recurrence between NO and NX Patients Subjected to Radical Prostatectomy: A Matched Analyses on 5977 Patients (2007)

You have accessJournal of UrologyPodium 11, Sunday, May 20, 2007 10:00 am - 12:00 pm1 Apr 2007321: No Differences in Biochemical Recurrence between NO and NX Patients Subjected to Radical Prostatectomy: A Matched Analyses on 5977 Patients Alexander Haese, Andrea Gallina, Jochen Walz, Diane Weber, Hans Heinzer, Eric A. Klein, Alwyn M. Reuther, James A. Eastham, Luigi F. Da Pozzo, Francesco Montorsi, Markus Graefen, Hartwig Huland, Fred Saad, and Pierre I. Karakiewicz Alexander HaeseAlexander Haese More articles by this author , Andrea GallinaAndrea Gallina More articles by this author , Jochen WalzJochen Walz More articles by this author , Diane WeberDiane Weber More articles by this author , Hans HeinzerHans Heinzer More articles by this author , Eric A. KleinEric A. Klein More articles by this author , Alwyn M. ReutherAlwyn M. Reuther More articles by this author , James A. EasthamJames A. Eastham More articles by this author , Luigi F. Da PozzoLuigi F. Da Pozzo More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , Markus GraefenMarkus Graefen More articles by this author , Hartwig HulandHartwig Huland More articles by this author , Fred SaadFred Saad More articles by this author , and Pierre I. KarakiewiczPierre I. Karakiewicz More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)30586-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "321: No Differences in Biochemical Recurrence between NO and NX Patients Subjected to Radical Prostatectomy: A Matched Analyses on 5977 Patients." The Journal of Urology, 177(4S), pp. 108–109 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 108-109 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Alexander Haese More articles by this author Andrea Gallina More articles by this author Jochen Walz More articles by this author Diane Weber More articles by this author Hans Heinzer More articles by this author Eric A. Klein More articles by this author Alwyn M. Reuther More articles by this author James A. Eastham More articles by this author Luigi F. Da Pozzo More articles by this author Francesco Montorsi More articles by this author Markus Graefen More articles by this author Hartwig Huland More articles by this author Fred Saad More articles by this author Pierre I. Karakiewicz More articles by this author Expand All Advertisement Loading ...
Application of full-system simulation in exploratory system design and development (2006)

This paper describes the design and application of a full-system simulation environment that has been widely used in the exploration of the IBM PowerPC® processor and system design. The IBM full-system simulator has been developed to meet the needs of hardware and software designers for fast, accurate, execution-driven simulation of complete systems, incorporating parameterized architectural models. This environment enables the development and tuning of production-level operating systems, compilers, and critical software support well in advance of hardware availability, which can significantly shorten the critical path of system development. The ability to develop early versions of software can benefit hardware development by identifying design issues that may affect functionality and performance far earlier in the development cycle, when they are much less costly to correct. In this paper, we describe features of the simulation environment and present examples of its application in the context of the Sony-Toshiba-IBM Cell Broadband Engine™ and IBM PERCS development projects.
Etching of ZnO Films with Hexafluoroacetylacetone (1998)

A dry route to etching metal oxides at low temperatures (<200°C) using gaseous β-diketones is described. The Figure is an SEM micrograph of a ZnO film after etching. This method is a promising alternative to current wet-etching and cleaning methods as easily desorbed, volatile, low-molecular-weight metal–organic products are produced.
Teaching silicon photonics using new technologies (2021)

To improve student learning experience in several photonics modules we teach at the University of Southampton, we use software packages for photonic circuit simulation and design, our cleanroom complex for the fabrication of the designed circuits, and experimental labs that we have developed for the characterisation.
ChemInform Abstract: The First Stable Zirconium Alkylidene Complex Formed via α‐ Hydrogen Abstraction: Synthesis and X‐Ray Crystal Structure of (η5‐ C5H3‐1,3‐(SiMe2CH2P(iPr)2)2)Zr=CHPh(Cl). (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.