gebhart/patrepeval huggingface dataset:
Topographical conformations of the deltorphins predicate .delta. opioid receptor affinity (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTopographical conformations of the deltorphins predicate .delta. opioid receptor affinitySharon D. Bryant, Severo Salvadori, Martti Attila, and Lawrence H. LazarusCite this: J. Am. Chem. Soc. 1993, 115, 18, 8503–8504Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/ja00071a092https://doi.org/10.1021/ja00071a092research-articleACS PublicationsRequest reuse permissionsArticle Views57Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Multifunctionality of chiton biomineralized armor with an integrated visual system (2015)

Nature provides a multitude of examples of multifunctional structural materials in which trade-offs are imposed by conflicting functional requirements. One such example is the biomineralized armor of the chiton Acanthopleura granulata, which incorporates an integrated sensory system that includes hundreds of eyes with aragonite-based lenses. We use optical experiments to demonstrate that these microscopic lenses are able to form images. Light scattering by the polycrystalline lenses is minimized by the use of relatively large, crystallographically aligned grains. Multiscale mechanical testing reveals that as the size, complexity, and functionality of the integrated sensory elements increase, the local mechanical performance of the armor decreases. However, A. granulata has evolved several strategies to compensate for its mechanical vulnerabilities to form a multipurpose system with co-optimized optical and structural functions.
ChemInform Abstract: Synthesis from D‐Mannose of 1,4‐Dideoxy‐1,4‐imino‐L‐ribitol and of the α‐Mannosidase Inhibitor 1,4‐Dideoxy‐1,4‐imino‐D‐talitol. (1988)

Abstract The synthesis of the title compounds (V) and (VII) is accomplished starting from the mannose derivative (I) which is transformed to the key precursor (II) by a known procedure and subsequent dimesylation.
Formation of chiral alkoxy dienes in Wittig/Michael reactions of 2,3,5-tri-O-benzyl-D-arabinose [Erratum to document cited in CA107(19):176331a] (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleFormation of chiral alkoxy dienes in Wittig/Michael reactions of 2,3,5-tri-O-benzyl-D-arabinose [Erratum to document cited in CA107(19):176331a]Allen B. Reitz, Alfonzo D. Jordan Jr., and Bruce E. MaryanoffCite this: J. Org. Chem. 1988, 53, 14, 3396Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://pubs.acs.org/doi/10.1021/jo00249a068https://doi.org/10.1021/jo00249a068research-articleACS PublicationsRequest reuse permissionsArticle Views40Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
TP508, a thrombin‐derived peptide, modulates TLR‐4 dependent cytokine expression in differentiated THP‐1 cells (2009)

Accelerated wound healing by TP508, a thrombin‐derived synthetic peptide, may involve inflammatory mediators. The mechanism of action for TP508 is hypothesized to be integrin binding at its RGD site. THP‐1 monocytes were differentiated to an adherent macrophage phenotype with 50 ng/mL phorbol 12‐myristate 13‐acetate (PMA). Cells were pretreated with TP508 for 30 minutes, followed by lipopolysaccharide (LPS) for 3.5 hours. TNFα, IL‐8 and IL‐1 β were analyzed via ELISA. TP508 decreased expression of TNFα and IL‐8 and increased IL‐1 β expression independently of LPS. When heparin‐sulfate was used to stimulate TLR4 receptors, TP508 again reduced TNFα expression. Given the peptide sequence of TP508, direct blocking of the TLR4 receptor is improbable, so the TP508 RGD site was explored for potential interaction with TLR4‐dependent cytokine stimulation. Variants of TP508 were used to test whether the RGD‐integrin binding was responsible for the reduction in cytokine expression in these cells. An α V β 3 integrin blocking antibody was as effective in reducing LPS‐stimulated cytokine expression as the TLR4 activity‐blocking antibody. Treatment of cells with α V β 3 integrin‐binding peptide GRGDSP also significantly reduced TNFα expression in response to LPS. This preliminary evidence suggests that TP508 may modulate cytokine expression through an integrin dependent mechanism.
The ups and downs in developing an under-ice moored profiler called the ICYCLER (2007)

The ICYCLER is a moored oceanographic profiler designed to measure surface layer water properties under mobile ice cover. The instrumentation is deployed in the Canadian Arctic Archipelago to measure the surface properties passing from the Arctic Ocean to the Atlantic Ocean. The profiler is designed to provide daily 50-meter salinity-temperature-chlorophyll profiles for a full year. A description of the ICYCLER design was presented at the ISOPE2003 conference (Fowler et al., 2004). An ICYCLER prototype was successfully used in the Canadian Arctic Archipelago during a year-long deployment. A second re-designed ICYCLER was deployed in the summer of 2004 but was not recovered until 2 years later. Simultaneous ice and oceanographic events caused the mooring to move 11miles eastwards into deeper waters where its buoyancy tank collapsed and the entire mooring sank to the bottom. Data presented showed that ice may have snagged the sensor float when it remained near the surface for a day because of excessive cable resulting from strong ocean currents.
Innate immune responses in patients treated with SBRT irradiation enhances prostate cancer remissions (2022)

Abstract Stereotactic body radiation therapy (SBRT) is a curative therapeutic modality employing large fractional doses of highly conformal radiation therapy for cancer treatment. To understand the mechanisms underlying clinical responses to radiation therapy, SBRT offers a unique window for high-throughput analysis of post-radiation molecular events to inform predictive biomarker discovery and strategies for multi-disciplinary therapeutics. We performed longitudinal analysis of plasma proteins and metabolites from patients treated with prostate SBRT, comparing cohorts of patients in clinical remission to cohorts experiencing PSA-determined cancer progression. We observed onset of post-SBRT DNA Damage Response (DDR), cell cycle arrest, and immune response signaling in patients within one hour of treatment and innate immune response signaling that persisted for up to three months following treatment. Furthermore, patients in remission experienced more robust immune responses and metabolite elevations consistent with a pro-inflammatory, M1-mediated innate immune activation in the short-term following SBRT, whereas patients with disease progression had less robust immune responses and M2-mediated metabolite elevations. We interpret these data to support a critical role for innate immune activation in the clinical outcomes of patients receiving radiation therapy for prostate cancer potentially improving future multidisciplinary therapeutic strategies. One Sentence Summary Following SBRT, proteomic and metabolomic profiles reveal a robust immune activation that correlates with prostate cancer remission
Coupling to Lysine-13 Promotes Electron Tunneling through Carboxylate-Terminated Alkanethiol Self-Assembled Monolayers to Cytochrome c (2003)

Electrochemistry of surface-modified cytochrome c (cyt c) bound electrostatically to carboxylate-terminated alkanethiol self-assembled monolayers (SAM) reveals highly anisotropic electronic coupling across the protein/monolayer interface. Substitution of a lysine residue with alanine at position 13 in recombinant rat cyt c (RC9-K13A) lowers the interfacial electron transfer (ET) rate more than 5 orders of magnitude, whereas ET is only slightly affected by replacement of lysine-72 or lysine-79 with alanine. The results clearly show that lysine-13 is directly involved in coupling the protein to the SAM carboxylate terminus. Interfacial ET rates for both yeast iso-1 cyt c and the mutant RC9-K13R indicate that arginine-13 couples the protein to the carboxylate interface less well than lysine-13.
Molecular properties of gp100‐reactive T‐cell receptors drive the cytokine profile and antitumor efficacy of transgenic host T cells (2018)

To study the contribution of T-cell receptors (TCR) to resulting T-cell responses, we studied three different human αβ TCRs, reactive to the same gp100-derived peptide presented in the context of HLA-A*0201. When expressed in primary CD8 T cells, all receptors elicited classic antigen-induced IFN-γ responses, which correlated with TCR affinity for peptide-MHC in the order T4H2 > R6C12 > SILv44. However, SILv44 elicited superior IL-17A release. Importantly, in vivo, SILv44-transgenic T cells mediated superior antitumor responses to 888-A2 + human melanoma tumor cells upon adoptive transfer into tumor-challenged mice while maintaining IL-17 expression. Modeling of the TCR ternary complexes suggested architectural differences between SILv44 and the other complexes, providing a potential structural basis for the observed differences. Overall, the data reveal a more prominent role for the T-cell receptor in defining host T-cell physiology than traditionally assumed, while parameters beyond IFN-γ secretion and TCR affinity ultimately determine the reactivity of tumor-reactive T cells.
The Frame Edge as an Internal Reference Line in Rotating-Mirror Framing Cameras (1965)

High-speed framing cameras, which make use of rotating mirrors acting as field stops, exhibit a changing field of view and frame size as the mirror rotates. The use of the frame edge as a reference line in data analysis from the film requires that the magnitude of these effects be known. A discussion of them and calculation of their magnitude for a Beckman & Whitley Model 189 Framing Camera are given.
Implementation of a High-Throughput Virtual Switch Port Monitoring System (2021)

As SDN-based networking infrastructure continues to evolve, an increasing number of traditional network functions are deployed over virtualized networks. Similar to fixed function switching networks, traffic monitoring in a Software Defined Network is critical in order to ensure the security and performance of the underlying infrastructure. In the context of virtualized networks, deployment of a virtualized TAP service has been reported as an effective VNF that can provide the same monitoring capabilities as a physical TAP. For most virtual switch implementations, e.g., OvS, network device virtualization is based upon a para-virtualization technology, i.e., VIRTIO. One of the primary use cases for port mirroring is inter-VM communication, i.e., packet streams that exist between virtual network devices, which remains prohibitively expensive for TAP devices. Specifically, it has been observed that virtual TAPs can contribute up to 70% performance degradation to the source VNF(s). With reference to prior work, we previously presented a feasibility study that included a novel approach towards the reduction of port-mirroring overhead. In this paper we present our latest contributions, in which we integrate our design into OvS and develop a VLAN based filtering scheme to pass traffic from a source device to a monitoring device. In this case, both devices may reside either within the same or different switch domains. Furthermore, we present an improvement over RSPAN and discuss its feasibility in delivering mirrored traffic across switch domains, which, in contrast to ERSPAN, does not require an L3 overlay network.
<title>Comparison of wavelet- and FFT-based single-channel speech signal noise reduction techniques</title> (2004)

This paper compares wavelet and short time Fourier transform based techniques for single channel speech signal noise reduction. Despite success of wavelet denoising of images, it has not yet been widely used for removal of noise in speech signals. We explored how to extend this technique to speech denoising, and discovered some problems in this endeavor. Experimental comparison with large amount test data has been performed. Our results have shown that although the Fourier domain methods still has the superiority, wavelet based alternatives can be very close, and enormous different configurations can still be tried out for possible better solutions.
The Importance of Dopamine Deficiency Evaluation in Non-Alzheimer Disease Dementias (2023)

BACKGROUND Dementia with Lewy bodies (DLB) is a common cause of dementia. Given the similarities between the symptoms of DLB and non-DLB Alzheimer disease (AD) and related dementias, patients can sometimes be misdiagnosed with AD. To increase the sensitivity of current DLB guidelines, the DLB Consortium published its fourth revised report in 2017 with increased diagnostic weight given to dopamine transporter (DAT) uptake in the basal ganglia, demonstrated by single-photon emission computed tomography or positron emission tomography imaging. We aimed to describe the role of DAT scans in evaluating dopamine deficiency in patients with overlapping symptoms of AD and DLB. CASE REPORT We present case studies of 3 patients with memory impairment who had a diagnosis of probable AD and were being treated with cholinesterase inhibitors. During treatment, dopamine deficiency was suspected and DAT scans were performed. All 3 patients revealed severe DAT deficits in the bilateral corpus striatum. These results were consistent with probable DLB as per the current revised DLB Consortium report. All patients received treatment with carbidopa/levodopa and demonstrated improved overall function. CONCLUSIONS All 3 of our cases demonstrated the role of DAT scans in evaluating dopamine deficiency syndromes in patients with overlapping symptoms of neurocognitive disorders. Thus, a DAT scan is critical for establishing an earlier and more definitive diagnosis of DLB, which provides treatment options for dopamine replacement. It also assists providers with prognostication of dopamine deficiency syndromes and is therefore beneficial in counseling patients and caregivers.
Ultrasmall Gold Nanoparticles Anchored to Graphene and Enhanced Photothermal Effects by Laser Irradiation of Gold Nanostructures in Graphene Oxide Solutions (2012)

In this work we demonstrate the coupling of the photothermal effects of gold nanostructures of controlled size and shape with graphene oxide nanosheets dispersed in water. The enhanced photothermal effects can be tuned by controlling the shape and size of the gold nanostructures, which result in a remarkable increase in the heating efficiency of the laser-induced size reduction of gold nanostructures. The Raman spectra of the Au-graphene nanosheets provide direct evidence for the presence of more structural defects in the graphene lattice induced by laser irradiation of graphene oxide nanosheets in the presence of Au nanostructures. The large surface areas of the laser-reduced graphene oxide nanosheets with multiple defect sites and vacancies provide efficient nucleation sites for the ultrasmall gold nanoparticles with diameters of 2-4 nm to be anchored to the graphene surface. This defect filling mechanism decreases the mobility of the ultrasmall gold nanoparticles and, thus, stabilizes the particles against the Ostwald ripening process, which leads to a broad size distribution of the laser-size-reduced gold nanoparticles. The Au nanostructures/graphene oxide solutions and the ultrasmall gold-graphene nanocomposites are proposed as promising materials for photothermal therapy and for the efficient conversion of solar energy into usable heat for a variety of thermal, thermochemical, and thermomechanical applications.
ChemInform Abstract: The Effect of Propargyl Oxygen Substituents in the Carbene Chromium/Alkyne Cycloaddition. (1990)

Abstract The monosubstituted alkynes (I) react with the chromium dimethoxyarylcarbene complex (II) to give the naphthols (III), furans (IV), and indenes (V) and (VI) depending on the substitution pattern.
Fabrication of wafer-scale free-standing quantum dot/polymer nanohybrid films for white-light-emitting diodes using an electrospray method (2014)

Wafer-scale free-standing quantum dot (QD)/polymer nanohybrid (NHB) based down-conversion (DC) phosphor films for remote-type white-light-emitting diodes (W-LEDs) are developed.
All-crystal fibers for high-power fiber lasers (2022)

Rare-earth-doped fibers with single-crystal cores have the potential for 10x higher TMI threshold than their glass counterparts and are a promising candidate for use as gain media in high-power laser systems. Their utility has been limited by parasitic optical losses and difficulty in fabrication. This paper explores methods to reduce the losses in these fibers in the core, in the cladding and at the core-cladding interface. Fabrication methods are also discussed.
Maximizing Information in Domain-Invariant Representation Improves Transfer Learning (2023)

We propose MaxDIRep, a domain adaptation method that improves the decomposition of data representations into domain-independent and domain-dependent components. Existing methods, such as Domain-Separation Networks (DSN), use a weak orthogonality constraint between these components, which can lead to label-relevant features being partially encoded in the domain-dependent representation (DDRep) rather than the domain-independent representation (DIRep). As a result, information crucial for target-domain classification may be missing from the DIRep. MaxDIRep addresses this issue by applying a Kullback-Leibler (KL) divergence constraint to minimize the information content of the DDRep, thereby encouraging the DIRep to retain features that are both domain-invariant and predictive of target labels. Through geometric analysis and an ablation study on synthetic datasets, we show why DSN's weaker constraint can lead to suboptimal adaptation. Experiments on standard image benchmarks and a network intrusion detection task demonstrate that MaxDIRep achieves strong performance, works with pretrained models, and generalizes to non-image classification tasks.
Asynchronous Communication (2010)

With the advent of digital video recorders and video-on-demand services, the way in which we consume media is undergoing a fundamental change. People today are less likely to watch shows at the same time, let alone the same place. As a result, television viewing which was once a social activity has been reduced to a passive, isolated experience. CollaboraTV was designed to address this new mode of television viewing by directly supporting asynchronous communication. We demonstrated its ability to support this communal viewing experience through a lab study and a month-long field study. Our studies show that users understand and appreciate the utility of asynchronous interaction, are enthusiastic about CollaboraTV’s engaging social communication primitives and value implicit show recommendations from friends. Our results both provide a compelling demonstration of a social television system and raise new challenges for social television communication modalities.
Transmission Electron Microscopic Observation of Layered Double Hydroxide Films Formed on Aluminum Alloys Prepared by Steam Coating Process (2019)

Microstructures and crystallographic features of layered double hydroxide (LDH) particles and the LDH film formed on the aluminum alloy sheet (alloy 7075) using the steam coating process were examined by transmission electron microscopy (TEM). The LDH powder particles exhibited a hexagonal-disc-shape morphology. Their disc plane and side planes were parallel to a basal plane and prism planes of the LDH hexagonal crystal, respectively. A cross-sectional thin TEM sample was prepared from the interface between the LDH film and the Al alloy substrate using a focused ion beam combined with pick-up technique. TEM observations revealed that the LDH film formed on the Al alloy exhibited a dual-layer structure, which consists of a continuous Zn-rich amorphous layer (including numerous nano-particles with fcc structure) on the Al substrate side and a LDH layer composed of a number of disc-shaped LDH particles.
ChemInform Abstract: Structure‐Activity Dependency of New Bacterial Tryptophanyl tRNA Synthetase Inhibitors. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Laboratory Findings on a Patient with Strongyloies Stercoralis Pulmonary Infection after Long Term Steroid Hormone and Immunosuppressive Treatment (2020)

<title>Abstract</title> <bold>Background:</bold> <italic>Strongyloies stercoralis </italic>infection is common in tropical and humid areas worldwide. However, strongyloidiasis caused by <italic>Strongyloies stercoralis </italic>infection is often neglected in clinic. We report a misdiagnosed case of <italic>Strongyloies stercoralis</italic> infected female patient who had been admitted to four different hospitals for treatment, she eventually died upon <italic>Strongyloies stercoralis</italic> hyperinfection with pulmonary infection involved.<bold>Case presentation:</bold> A <italic>Strongyloies stercoralis </italic>infected woman was misdiagnosed as community acquired pneumonia, connective tissue disease and Sjogren's syndrome, and treated by mistake.She eventually died upon <italic>Strongyloies stercoralis</italic> hyperinfection with pulmonary infection involved. The patient’s clinical presentations, imaging results of the lungs, numerous <italic>Strongyloies Stercoralis </italic>larvae and eggs found in the stool, increased eosenophil count in peripheral blood, and elevated serological IgE level were evidences of <italic>Strongyloies stercoralis </italic>hyperinfection.<bold>Conclusion:</bold> The patient was infected with <italic>Strongyloies Stercoralis </italic>and died from the hyperinfection after long term use of immunosuppressive agents.