gebhart/patrepeval huggingface dataset:
Monodromy zeta-function of a polynomial on a complete intersection and\n Newton polyhedra (2012)

For a generic (polynomial) one-parameter deformation of a complete\nintersection, there is defined its monodromy zeta-function. We provide explicit\nformulae for this zeta-function in terms of the corresponding Newton polyhedra\nin the case the deformation is non-degenerate with respect to its Newton\npolyhedra. Using this result we obtain the formula for the monodromy\nzeta-function at the origin of a polynomial on a complete intersection, which\nis an analog of the Libgober--Sperber theorem.\n
Effect of coating heating by high power in optical fibres at small bend diameters (2003)

The heating effect in highly bent singlemode optical fibres under high power conditions was studied. It was found that heating of the coating depends on the bend radius and the type of telecommunication fibre used. The detected heating only occurred at bend diameters much smaller than that recommended for normal deployment.
Research highlights: microfluidics meets big data (2014)

In this issue we highlight a collection of recent work in which microfluidic parallelization and automation have been employed to address the increasing need for large amounts of quantitative data concerning cellular function--from correlating microRNA levels to protein expression, increasing the throughput and reducing the noise when studying protein dynamics in single-cells, and understanding how signal dynamics encodes information. The painstaking dissection of cellular pathways one protein at a time appears to be coming to an end, leading to more rapid discoveries which will inevitably translate to better cellular control--in producing useful gene products and treating disease at the individual cell level. From these studies it is also clear that development of large scale mutant or fusion libraries, automation of microscopy, image analysis, and data extraction will be key components as microfluidics contributes its strengths to aid systems biology moving forward.
Teen Traffic Safety Campaign: Competition Is the Key (2010)

: Social pressure and poor comprehension of the risks of injury were identified as barriers to seat belt usage among teenage high school students. A friendly, competitive approach to openly discussing and educating teens about these risks led to a 20% increase in seat belt usage among teen drivers and their passengers.
Order Reduction for a Control-Oriented Model of the Water Dynamics in Fuel Cells (2006)

Predicting the water dynamics and estimating humidity and flooding conditions in a low-temperature fuel cell are critical for robust operation and long life. Previous work by McKay et al [1] shows that the fuel cell anode, cathode, and membrane water dynamics and gaseous species concentrations can be accurately modeled by discretizing the partial differential equations that describe mass transport into three segments. Avoiding sensitivities associated with over-parameterization, and allowing for the real-time computations necessary for embedded controllers, requires in-depth investigation of the model order. In this paper the model from [1] is formulated into a bond graph representation. The objective is to establish the necessary model order for the fuel cell model using the Model Order Reduction Algorithm (MORA) [2], where an energy-based metric termed the Activity is used to quantify the contribution of each element of the model. Activity is a scalar quantity that is determined from the generalized effort and flow through each element of the model. We show the degree of model order reduction and provide a guideline for appropriate discretization.
AGS16F Is a Novel Antibody Drug Conjugate Directed against ENPP3 for the Treatment of Renal Cell Carcinoma (2015)

AGS16F is a promising new therapeutic option for patients with RCC and is currently being evaluated in a phase I clinical trial.
Interpretation of isopotential points. Common intersection in families of current-potential curves (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInterpretation of isopotential points. Common intersection in families of current-potential curvesD. F. Untereker and Stanley. BruckensteinCite this: Anal. Chem. 1972, 44, 6, 1009–1020Publication Date (Print):May 1, 1972Publication History Published online1 May 2002Published inissue 1 May 1972https://doi.org/10.1021/ac60314a017RIGHTS & PERMISSIONSArticle Views179Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
Fault-locating technique for multi-staged optical distribution networks (1994)

Optical power splitters are extensively used in many fiber-optic distribution networks such as CATV and fiber-to-the-home systems. Techniques for locating any fiber link faults become more important after the installation of such distribution networks. However, today's optical time-domain reflectometer (OTDR) is unable to diagnose N-branched networks, e.g., N &gt; 4, due to lack of high spatial resolution with sufficient singleway dynamic range (SDR). To overcome this problem, we propose and demonstrate a fault-locating technique for large multistaged branched networks. The requirement of ultra-wide SDR with high resolution of an OTDR to diagnose a large distribution network can be tremendously relaxed by the introduction of optical switches and the wavelength division multiplexing technique.
Inverse surrogate modeling: output performance space sampling (2010)

The use of Surrogate Based Optimization (SBO) is widely spread in engineering design to find optimal performance characteristics of computational expensive simulation codes (i.e., the forward problem). However, often the practitioner knows a priori the desired performance and is interested in finding the associated design parameters (i.e., the inverse problem). A popular method to solve such reverse (inverse) problems is to minimize the error between the simulated performance and the desired goal performance. While this works quite well, it only allows for the identification of one design, namely, the global optimum according to the error function. In this paper, the authors propose a method to sample a whole range of performances using surrogate models. This technique, based on the probability of improvement criterion and kriging models, is successfully demonstrated on the branin function to obtain a quasi-uniform set of samples that lie in a predefined output range.
Inclusive Design (2017)

As part of the PocketArchitecture Series, this volume focuses on inclusive design and its allied fields—ergonomics, accessibility, and participatory design. This book aims for the direct application of inclusive design concepts and technical information into architectural and interior design practices, construction, facilities management, and property development. A central goal is to illustrate the aesthetic, experiential, qualitative, and economic consequences of design decisions and methods. The book is intended to be a ‘first-source’ reference—at the desk or in the field—for design professionals, contractors and builders, developers, and building owners.
Broadening the Sub-Standard-Quantum-Limit Region in Quantum Noise Limited Sensitivity for Gravitational Wave Detectors (2014)

We present schemes for gravitational wave detectors that incorporate anomalous dispersion in signal recycling, exhibiting a broad region below the standard quantum limit in the quantum noise limited sensitivity curves, which corresponds to opto-mechanical resonance.
Issues in the 2-D simulation physics of high-performance Z-pinch experiments (2003)

Summary form only given, as follows. Recent experiments conducted on the Sandia Z accelerator have continued the progress which began with the Saturn large-wire-number array implosions. Included in this progress was the discovery that total radiated energy is roughly independent of pinch length leading to improved power/length performance for short length pinches; the use of "nested" arrays to reduce instability effects, increase power and decrease pulsewidth; and the employment of on-axis cylindrical foam targets to create high-temperature (>200 eV) "dynamic hohlraums". Two-dimensional simulations have confirmed and provided an explanation for the results from short length pinches and produced good matches to measured currents, radiation powers and energies for a variety of experimental configurations. Simulations of nested array implosions and dynamic hohlraum experiments have also reproduced important results and in some cases were able to provide accurate predictions of experimental results. In other cases, the experimental performance has not matched the simulation results, at times with better experimental performance than expected. In this presentation, we will review the successful match which has been achieved of 2-D simulations to experimental data and examine the underlying physical mechanisms which appear to be important. In addition, comparisons will be made with experiments which have not been as well matched, and examine possibilities for the underlying physical mechanisms which may be responsible.
Ultra-compact broadband TE-pass polarizer based on vanadate-nanowire-integrated SOI waveguides (2017)

An ultra-compact TE-pass polarizer is numerically demonstrated at telecommunication wavelengths by integrating a vanadate nanowire with a SOI platform. Results show that a device of 15 μm in length is capable of achieving a high extinction ratio of 22 ~ 34 dB, in conjunction with a low insertion loss of 0.18 ~ 0.23 dB in a wavelength range of 1.52 ~ 1.62 μm.
Multilingual open-content signal processing laboratories in Connexions (2004)

Due to inherent factors like a small and fragmented market and rapid hardware obsolescence, the conventional textbook is inadequate for DSP laboratory education. Freely available open-content materials that enable and promote both local customization and further development by a community of educators offer a fresh approach to lab text development that can surmount these barriers. In this paper, we overview a joint effort under the aegis of the Connexions project to develop a large pool of DSP lab modules sufficient to serve as a complete, stand-alone text for several types of DSP lab courses. In addition, we introduce a pilot project whose aim is to demonstrate the suitability of using Connexions for languages other than English, such as the Japanese, Chinese and Thai languages.
ChemInform Abstract: Palladium‐Catalyzed Regio‐ and Stereoselective Synthesis of Allylic Amines. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Experiences with java/sup tm/ jit optimization (2005)

This paper presents some experiences with a Java just-in-time (JIT) compiler developed at Intel Corporation. For a few optimizations, the issues that are specific to Java programs are discussed. Furthermore, because in the context of a just-intime compilation, compile-time directly contributes to the run-time of the application, some remarks are made on how program analysis time is kept limited in our compiler. A preliminary experiment explores the impact of the presented optimizations.
Complex Buckling Instability Patterns of Nanomembranes with Encapsulated Gold Nanoparticle Arrays (2006)

The nanomechanical properties of micropatterned nanomembranes containing gold nanoparticle microarrays were investigated with the buckling instability method. An unusual, complex pattern of buckling instability was observed for the nanoscale polymeric films under compressive stresses. An intriguing two-stage wrinkling was observed for these nanoscale films with spatially correlated instabilities. Two concurrent strain-dependent buckling modes were observed above a certain critical strain. Transformation from conventional transversal buckling mode to zigzag buckling is attributed to the development of the biaxial stress along the boundary lines for micropatterned areas. The binary buckling pattern observed here allowed the "one-shot" evaluation of the elastic moduli of two compositionally different regions (with and without gold nanoparticles).
Understanding TCP dynamics in an integrated services Internet (2002)

A large number of Internet applications are sensitive to overload conditions in the network. While these applications have been designed to adapt somewhat to the varying conditions in the Internet, they can benefit greatly from an increased level of predictability in network services. We propose minor extensions to the packet queueing and discard mechanisms used in routers, coupled with simple control mechanisms at the source that enable the network to guarantee minimal levels of throughput to different network sessions while sharing the residual network capacity in a cooperative manner. The service realized by the proposed mechanisms is an interpretation of the controlled-load service being standardized by the IETF. Although controlled-load service can be used in conjunction with any transport protocol, our focus in this paper is on understanding its interaction with TCP. Specifically, we study the dynamics of TCP traffic in an integrated services network that simultaneously supports both best-effort and controlled-load sessions. In light of this study, we propose and experiment with several variations to TCP's control mechanisms with the objective of fine-tuning them for an integrated services environment. We then investigate the overheads associated with these enhancements and the benefits they provide. Finally, we show how the service mechanisms proposed here can be embedded within more elaborate packet and link scheduling frameworks in a fully-evolved integrated services Internet.
Real-time Bacterial Detection by Single Cell Based Sensors UsingSynchrotron FTIR Spectromicroscopy (2005)

Microarrays of single macrophage cell based sensors weredeveloped and demonstrated for real time bacterium detection bysynchrotron FTIR microscopy. The cells were patterned on gold-SiO2substrates via a surface engineering technique by which the goldelectrodes were immobilized with fibronectin to mediate cell adhesion andthe silicon oxide background were passivated with PEG to resist proteinadsorption and cell adhesion. Cellular morphology and IR spectra ofsingle, double, and triple cells on gold electrodes exposed tolipopolysaccharide (LPS) of different concentrations were compared toreveal the detection capabilities of these biosensors. The single-cellbased sensors were found to generate the most significant IR wave numbervariation and thus provide the highest detection sensitivity. Changes inmorphology and IR spectrum for single cells exposed to LPS were found tobe time- and concentration-dependent and correlated with each other verywell. FTIR spectra from single cell arrays of gold electrodes withsurface area of 25 mu-m2, 100 mu-m2, and 400 mu-m2 were acquired usingboth synchrotron and conventional FTIR spectromicroscopes to study thesensitivity of detection. The results indicated that the developedsingle-cell platform can be used with conventional FTIRspectromicroscopy. This technique provides real-time, label-free, andrapid bacterial detection, and may allow for statistic and highthroughput analyses, and portability.
Fuctional organization of the outer membrane of escherichia coli: Phage and colicin receptors as components of iron uptake systems (1976)

The functional interaction of outer membrane proteins of E. coli can be studied using phage and colicin receptors which are essential components of penetration systems. The uptake of ferric iron in the form of the ferrichrome complex requires the ton A and ton B functions in the outer membrane of E. coli. The ton A gene product is the receptor protein for phage T5 and is required together with the ton B function by the phages T1 and ø80 to infect cells and by colicin M and the antibiotic albomycin, a structural analogue of ferrichrome, to kill cells. The ton B function is necessary for the uptake of ferric iron complexed by citrate. Iron complexed by enterochelin is only transported in the presence of the ton B and feu functions. Cells which have lost the feu function are resistant to the colicins B, I or V while ton B mutants are resistant to all 3 colicins. The interaction of the ton A, ton B, and feu functions apparently permits quite different "substrates" to overcome the permeability barrier of the outer membrane. It was shown for ferrichrome dependent iron uptake that the complexing agent was not altered and could be used repeatedly. Only very low amounts of 3H-labeled ferrichrome were found in the cell. It is possible that the iron is mobilized in the membrane and that desferri-ferrichrome is released into the medium without having entered the cytoplasm. Growth on ferrichrome as the sole iron source was used to select revertants of T5 resistant ton A mutants. All revertants exhibited wild-type properties with the exception of partial revertants. In these 4 strains, as in the ton A mutants, the ton A protein was not detectable by SDS polyacrylamide gel electrophoreses of outer membranes. Albomycin resistant mutants were selected and shown to fall into 5 categories: 1) ton A; 2) ton B mutants; 3) mutants with no iron transport defects and normal ton A/ton B functions, which might be target site mutants; 4) mutants which were deficient in ferrichrome-mediated iron uptake but had normal ton A/ton B functions. We tentatively consider that the defect might be located in the active transport system of the cytoplasmic membrane; 5) a variety of mutants with the following general properties: most of them were resistant to colicin M, transported iron poorly, and, like ton B mutants, contained additional proteins in the outer membrane. The outer membrane protein patterns of wild-type and ton B mutant strains were compared by slab gel electrophoresis in an attempt to identify a ton B protein. It was observed that under most growth conditions, ton B mutants overproduced 3 proteins of molecular weights 74,000-83,000. In extracted, iron-deficient medium, both the wild-type and ton B mutant strains had similar large amounts of these proteins in their outer membranes. The appearance of these proteins was suppressed by excess iron in both wild-type and mutant. From this evidence it is apparent that the proteins appear as a response to low intracellular iron rather than being controlled by the ton B gene...
Geometric and Electronic Structure Analysis of the Three-Membered Electron-Transfer Series [(μ-CNR)2[CpCo]2]n (n = 0, 1–, 2−) and Its Relevance to the Classical Bridging-Carbonyl System (2017)

The dimeric bridging carbonyl complexes [(μ-CO)2[CpCo]2]n (n = 0, 1−) have occupied a central position in the understanding of metal–metal bonding interactions when bridging ligands are present. Based on simple electron-counting formalisms, these dimers have been proposed to possess formal Co–Co bond orders of 2 and 1.5, respectively. However, this simple bonding scheme has been contrasted by molecular orbital theory considerations, as well as spectroscopic data that probes M–M bonding interactions generally. While this system has received considerable attention, there has been a long-standing synthetic limitation in that the doubly reduced dianionic dimer, [(μ-CO)2[CpCo]2]2–, has not been amenable to isolation, thereby precluding an analysis of ostensible full-integer reduction in a homologous series. Accordingly, herein is presented the synthesis of a homologous, three-membered series of bridging-isocyanide [(μ-CNAr)2[CpCo]2]n dimers, including the dianionic member. Structural and spectroscopic analyses of these [(μ-CNAr)2[CpCo]2]n dimers, which feature the m-terphenyl isocyanide CNArMes2 (ArMes2 = 2,6-(2,4,6-Me3C6H2)2C6H3), reveal that this series possesses similar overall properties to the bridging carbonyl counterparts. However, high-resolution X-ray crystallographic studies have revealed important structural differences that were not discernible in older studies of the carbonyl complexes. Also presented is the synthesis of the bridging-isocyanide/η6-arene dimers [Co2((η6-Mes)(μ-CNArMes))2]n (n = 0, 1+), which are valence isoelectronic to the mono- and dianionic [(μ-CNAr)2[CpCo]2]n derivatives. Structural and spectroscopic studies of these η6-arene complexes, as well as the related neutral nickel dimer (μ-CNArMes)2[CpNi]2 provide evidence for an electronic structure environment dominated by M→(CN)π* back-bonding interactions, rather than direct M–M bonding. This conclusion is supported by DFT-derived molecular orbital analysis on the bridging-isocyanide [(μ-CNArMes2)2[CpCo]2]n dimers.
Gram‐Scale Preparation of C‐Terminal‐Modified Enkephalin Analogues by Typical Liquid‐Phase Peptide Synthesis (2019)

This article describes the gram-scale liquid-phase peptide synthesis of C-terminal-modified enkephalin analogues that possess high analgesic efficacy in animals, high potency for mu and delta opioid receptors, and high metabolic stability and potential blood-brain barrier permeability. Despite the long cycle time and tedious purification steps, liquid-phase synthesis is still a preferred method for large-scale peptide synthesis due to its cost effectiveness (i.e., amount of amino acids and reagents required), easy detection, and isolation of impurities compared with solid-phase synthesis. A robust liquid-phase synthesis protocol is described, involving BOP-assisted coupling and Boc deprotection, which has been well established in the laboratory and is a useful synthetic protocol for cost-effective production of peptide drugs. © 2019 by John Wiley & Sons, Inc.
Dual-surface substrate for in situ wearable surface-enhanced Raman spectroscopy (Conference Presentation) (2023)

Wearable sensor technology is a powerful tool, but conventional wearable sensors cannot perform simultaneous chemical sensing of multiple biomarkers in biofluids such as sweat and saliva because they are typically sensitive to only one type of chemical in an analyte at a time. Here we present a wearable dual-surface substrate for in situ surface-enhanced Raman spectroscopy (SERS). The substrate is composed of a gold nanomesh structure that can be tailored into any shape and attached to virtually any surface. Notedly, SERS can be performed on both surfaces of the substrate, highly effective for multiplexed in situ chemical sensing of biofluids.
Supplemental Table 8 from Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics (2023)

&lt;p&gt;Supplemental Table 8&lt;/p&gt;
Modification of GEM to Accommodate Changes in a Classification Scheme (2001)

Through this collaboration, we were able to integrate a proposed expansion of the National Guideline Clearinghouse (NGC) guideline classification into the XML based Guideline Elements Model (GEM).1 2 We conclude that GEM, through its utilization of XML is flexible enough to accommodate externally developed concepts. We hope to use this result to expand upon a preliminary evaluation of the guideline classification using GEM tools.