gebhart/patrepeval huggingface dataset:
Chiral Economy with Respect to Rotational Isomerism: Rational Synthesis of Hamatine and (Optionally) Ancistrocladine from Joint Helical Precursors (1989)

on the occasion of his 70th birthday &&& -Unlike the target alkaloids la and l b , which are configurationally stable at the biaryl linkage, the helicene-like distorted cyclic precursors 2 and 7 show dramatically lowered rotational thresholds: they equilibrate at room temperature, already.In contrast to the lactones 2a/b, however, the cyclic ethers 74 and 7b interconvert slowly enough to be separated conveniently, on a preparative scale.Ring opening of the desired helimer (e.g.7b) and re-equilibrationlre-separation of the rest allows the transformation of practically the whole synthetic material, optionally into lb or lapractising "axially chiral economy".Ancistrocladine3 (la) is the most widespread representative of the naphthylisoquinoline alkaloidsa remarkable group o f meanwhile nearly 30 related, structurally intriguing compounds4.These interesting natural products are found in tropical lianas belonging to the plant families of the Ancistrocladaceae and the Dioncophyllaceae.Biomimetic syntheses of both molecular partsthe naphthalene andthe isoquinoline mietiesfrom identical 0-polycarbonyl precursors strongly suggest an unprecedented biosynthesis from acetate units5.Besides these biosynthetic aspects, the most evident structural feature of la is its highly hindered biaryl linkage, which gives rise to rotational isomers that are configurationally
Online Grid Measurement and ENS Detection for PV Inverter Running on Highly Inductive Grid (2004)

Photovoltaic (PV) and other sources of renewable energy are being used increasingly in grid-connected systems, for which stronger power quality requirements are being issued. Continuous grid monitoring should be considered so as to provide safe connections and disconnections from the grid. This letter gives an overview of the methods used for online grid measurement with PV inverters. Emphasis is placed on a method based on the injection of a noncharacteristic harmonic in the grid. Since this injection is regarded as a disturbance for the grid, different issues, i.e., the influence on total harmonic distortion (THD), the accuracy of line impedance measurement and the ENS (German abbreviation of Main Monitoring units with allocated Switching Devices) detection are studied. Laboratory results conducted on an existing PV inverter are presented to demonstrate the behavior of the PV inverter under different grid conditions. Some of the injection parameters are tuned in order to get an accurate measurement of line impedance.
Volterra series modelling and compensation of non-linear distortions caused by susceptibility difference artefacts related to the presence of ferromagnetic implants in magnetic resonance imaging (2001)

Magnetic resonance imaging is popular in medical settings due to its unique technical characteristics. However, its full potential has been limited by imaging artefacts caused by various phenomena. Previously, a methodology was proposed to characterize and reduce artefacts caused specifically by magnetic susceptibility differences. In the present work, the Volterra series approach is suggested as an alternative method for describing non-linear distortions induced by susceptibility artefacts. A second-order Volterra series is utilized for characterizing the image non-linearities using a block-by-block processing approach. Subsequently, a corresponding second-order inverse Volterra series is applied to compensate for the quantified distortions. In addition, a technique for automatic demarcation of recoverable and non-recoverable regions in magnetic resonance images is proposed to ameliorate the developed methodology. Experimental results indicate that this approach offers improved accuracy and flexibility in reducing non-linear distortions caused by magnetic susceptibility artefacts.
A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion (2013)

LJ001 is a lipophilic thiazolidine derivative that inhibits the entry of numerous enveloped viruses at non-cytotoxic concentrations (IC50 ≤ 0.5 µM), and was posited to exploit the physiological difference between static viral membranes and biogenic cellular membranes. We now report on the molecular mechanism that results in LJ001's specific inhibition of virus-cell fusion. The antiviral activity of LJ001 was light-dependent, required the presence of molecular oxygen, and was reversed by singlet oxygen ((1)O2) quenchers, qualifying LJ001 as a type II photosensitizer. Unsaturated phospholipids were the main target modified by LJ001-generated (1)O2. Hydroxylated fatty acid species were detected in model and viral membranes treated with LJ001, but not its inactive molecular analog, LJ025. (1)O2-mediated allylic hydroxylation of unsaturated phospholipids leads to a trans-isomerization of the double bond and concurrent formation of a hydroxyl group in the middle of the hydrophobic lipid bilayer. LJ001-induced (1)O2-mediated lipid oxidation negatively impacts on the biophysical properties of viral membranes (membrane curvature and fluidity) critical for productive virus-cell membrane fusion. LJ001 did not mediate any apparent damage on biogenic cellular membranes, likely due to multiple endogenous cytoprotection mechanisms against phospholipid hydroperoxides. Based on our understanding of LJ001's mechanism of action, we designed a new class of membrane-intercalating photosensitizers to overcome LJ001's limitations for use as an in vivo antiviral agent. Structure activity relationship (SAR) studies led to a novel class of compounds (oxazolidine-2,4-dithiones) with (1) 100-fold improved in vitro potency (IC50<10 nM), (2) red-shifted absorption spectra (for better tissue penetration), (3) increased quantum yield (efficiency of (1)O2 generation), and (4) 10-100-fold improved bioavailability. Candidate compounds in our new series moderately but significantly (p≤0.01) delayed the time to death in a murine lethal challenge model of Rift Valley Fever Virus (RVFV). The viral membrane may be a viable target for broad-spectrum antivirals that target virus-cell fusion.
“Biting the Sour Apple”: The Nietzschean Undertow in Little Eyolf (2009)

In this essay, Little Eyolf is treated as a play that offers compelling internal evidence of Ibsen's critical, intertextual engagement with Nietzche. Not only does the play invoke the Nietzschean imagery associated with lower chthonic powers and transfiguration rites, but its complex mess of dysfunctional relations articulates a starkly Nietzschean critique of the existential limitations of bourgeois consciousness. While Ibsen may appropriate the dialectical interplay of Dionysian and Apollonian principles as the shaping forces at work in the gender and identity problems of the play, his assimilation of the key metaphors of Nietzsche's philosophical poetics does not prevent him from developing a daring, proto-feminist critique of aristocratic radicalism and the übermensch fantasy of self-overcoming. The argument is designed to celebrate the rhetorical possibility that Ibsen's playful, improvisational thinking with these key Nietzschean metaphors reveals a rat-catcher of human consciousness unmatched by anything in “that old maid,” Nietzsche.
Measurement of an Excess in the Yield ofJ/ψat Very LowpTin Pb–Pb Collisions atsNN=2.76  TeV (2016)

We report on the first measurement of an excess in the yield of J/ψ at very low transverse momentum (p_{T}<0.3 GeV/c) in peripheral hadronic Pb-Pb collisions at sqrt[s_{NN}]=2.76 TeV, performed by ALICE at the CERN LHC. Remarkably, the measured nuclear modification factor of J/ψ in the rapidity range 2.5<y<4 reaches about 7 (2) in the p_{T} range 0-0.3 GeV/c in the 70%-90% (50%-70%) centrality class. The J/ψ production cross section associated with the observed excess is obtained under the hypothesis that coherent photoproduction of J/ψ is the underlying physics mechanism. If confirmed, the observation of J/ψ coherent photoproduction in Pb-Pb collisions at impact parameters smaller than twice the nuclear radius opens new theoretical and experimental challenges and opportunities. In particular, coherent photoproduction accompanying hadronic collisions may provide insight into the dynamics of photoproduction and nuclear reactions, as well as become a novel probe of the quark-gluon plasma.
SPLADE v2: Sparse Lexical and Expansion Model for Information Retrieval (2021)

In neural Information Retrieval (IR), ongoing research is directed towards improving the first retriever in ranking pipelines. Learning dense embeddings to conduct retrieval using efficient approximate nearest neighbors methods has proven to work well. Meanwhile, there has been a growing interest in learning \emph{sparse} representations for documents and queries, that could inherit from the desirable properties of bag-of-words models such as the exact matching of terms and the efficiency of inverted indexes. Introduced recently, the SPLADE model provides highly sparse representations and competitive results with respect to state-of-the-art dense and sparse approaches. In this paper, we build on SPLADE and propose several significant improvements in terms of effectiveness and/or efficiency. More specifically, we modify the pooling mechanism, benchmark a model solely based on document expansion, and introduce models trained with distillation. We also report results on the BEIR benchmark. Overall, SPLADE is considerably improved with more than $9$\% gains on NDCG@10 on TREC DL 2019, leading to state-of-the-art results on the BEIR benchmark.
Dynamic jamming of dense suspensions under tilted impact (2018)

Dense particulate suspensions can not only increase their viscosity and shear thicken under external forcing, but also jam into a solid-like state that is fully reversible when the force is removed. An impact on the surface of a dense suspension can trigger this jamming process by generating a shear front that propagates into the bulk of the system. Tracking and visualizing such a front is difficult because suspensions are optically opaque and the front can propagate as fast as several meters per second. Recently, high-speed ultrasound imaging has been used to overcome this problem and extract two-dimensional sections of the flow field associated with jamming front propagation. Here we extend this method to reconstruct the three-dimensional flow field. This enables us to investigate the evolution of jamming fronts for which axisymmetry cannot be assumed, such as impact at angles tilted away from the normal to the free surface of the suspension. We find that sufficiently far from solid boundaries the resulting flow field is approximately identical to that generated by normal impact, but rotated and aligned with the angle of impact. However, once the front approaches the solid boundary at the bottom of the container, it generates a squeeze flow that deforms the front profile and causes jamming to proceed in a non-axisymmetric manner.
Passage of Classical Swine Fever Virus in Cultured Swine Kidney Cells Selects Virus Variants That Bind to Heparan Sulfate due to a Single Amino Acid Change in Envelope Protein E rns (2000)

Infection of cells with Classical swine fever virus (CSFV) is mediated by the interaction of envelope glycoprotein E(rns) and E2 with the cell surface. In this report we studied the role of the cell surface glycoaminoglycans (GAGs), chondroitin sulfates A, B, and C (CS-A, -B, and -C), and heparan sulfate (HS) in the initial binding of CSFV strain Brescia to cells. Removal of HS from the surface of swine kidney cells (SK6) by heparinase I treatment almost completely abolished infection of these cells with virus that was extensively passaged in swine kidney cells before it was cloned (clone C1.1.1). Infection with C1.1.1 was inhibited completely by heparin (a GAG chemically related to HS but sulfated to a higher extent) and by dextran sulfate (an artificial highly sulfated polysaccharide), whereas HS and CS-A, -B, and -C were unable to inhibit infection. Bound C1.1.1 virus particles were released from the cell surface by treatment with heparin. Furthermore, C1.1.1 virus particles and CSFV E(rns) purified from insect cells bound to immobilized heparin, whereas purified CSFV E2 did not. These results indicate that initial binding of this virus clone is accomplished by the interaction of E(rns) with cell surface HS. In contrast, infection of SK6 cells with virus clones isolated from the blood of an infected pig and minimally passaged in SK6 cells was not affected by heparinase I treatment of cells and the addition of heparin to the medium. However, after one additional round of amplification in SK6 cells, infection with these virus clones was affected by heparinase I treatment and heparin. Sequence analysis of the E(rns) genes of these virus clones before and after amplification in SK6 cells showed that passage in SK6 cells resulted in a change of an Ser residue to an Arg residue in the C terminus of E(rns) (amino acid 476 in the polyprotein of CSFV). Replacement of the E(rns) gene of an infectious DNA copy of C1.1.1 with the E(rns) genes of these virus variants proved that acquisition of this Arg was sufficient to alter an HS-independent virus to a virus that uses HS as an E(rns) receptor.
Dendrimer-Encapsulated Camptothecins: Increased Solubility, Cellular Uptake, and Cellular Retention Affords Enhanced Anticancer Activity In vitro (2006)

A biocompatible polyester dendrimer composed of the natural metabolites, glycerol and succinic acid, is described for the encapsulation of the antitumor camptothecins, 10-hydroxycamptothecin and 7-butyl-10-aminocamptothecin. The cytotoxicity of the dendrimer-drug complex toward four different human cancer cell lines [human breast adenocarcinoma (MCF-7), colorectal adenocarcinoma (HT-29), non-small cell lung carcinoma (NCI-H460), and glioblastoma (SF-268)] is also reported, and low nmol/L IC(50) values are measured. Cellular uptake and efflux measurements in MCF-7 cells show an increase of 16-fold for cellular uptake and an increase in drug retention within the cell when using the dendrimer vehicle.
Initial stages of calcium uptake and mineral deposition in sea urchin embryos (2013)

Sea urchin larvae have an endoskeleton consisting of two calcitic spicules. We reconstructed various stages of the formation pathway of calcium carbonate from calcium ions in sea water to mineral deposition and integration into the forming spicules. Monitoring calcium uptake with the fluorescent dye calcein shows that calcium ions first penetrate the embryo and later are deposited intracellularly. Surprisingly, calcium carbonate deposits are distributed widely all over the embryo, including in the primary mesenchyme cells and in the surface epithelial cells. Using cryo-SEM, we show that the intracellular calcium carbonate deposits are contained in vesicles of diameter 0.5-1.5 μm. Using the newly developed airSEM, which allows direct correlation between fluorescence and energy dispersive spectroscopy, we confirmed the presence of solid calcium carbonate in the vesicles. This mineral phase appears as aggregates of 20-30-nm nanospheres, consistent with amorphous calcium carbonate. The aggregates finally are introduced into the spicule compartment, where they integrate into the growing spicule.
THE ROLE OF CRAVING IN FAILURE OF DRUG DETOXIFICATION (1996)

KOOP, G F; CAINE, S B; PARSONS, L H; WEISS, F; SOKOLOFF, P; SCHWARTZ, J-C Author Information
Invisible Inks: A New Anti‐Counterfeiting Feature Relying on Invisible Luminescent Full Color Images Printed with Lanthanide‐Based Inks (Adv. Funct. Mater. 32/2014) (2014)

A.-S. Chauvin and co-workers print lanthanide complexes on paper and, by controlling and calibrating an inkjet printer, obtain accurately reproduced luminescent images that are invisible under daylight but appear to glow under UV light. On page 5029, this shining application demonstrates the potential of luminescent lanthanide complexes to build unique anti-counterfeit features that are both beautiful and difficult to reproduce. The frontispiece picture is a simple illustration of the material workflow involved in the production of such prints.
An informatics approach identifying markers of chemosensitivity in human cancer cell lines. (2000)

We have used a sensitive and reproducible method of measuring mRNA expression to compare basal levels of 10 transcripts in the 60 cell lines of the National Cancer Institute's in vitro anticancer drug screen (NCI-ACDS) under conditions of exponential growth. The strongest correlation among these target genes was between levels of CIP1/WAF1 and BAX. Levels of the three major growth arrest and DNA damage-inducible gene transcripts, (GADD34, GADD45, and GADD153), which are coordinately regulated in response to many stresses, were also correlated across the 60 cell lines. Although the stress induction of several of the transcripts studied here has been shown to be dependent on wild-type p53 status, basal levels of only CIP1/WAF1 and BAX were found to correlate with p53 status. As expected, basal expression of O6 alkyl guanine alkyl-transferase correlated well with resistance to O6-alkylating agents (r = -0.44) but not with resistance to alkylators with different mechanisms of action (r = -0.04). When basal expression levels of the 10 genes across the NCI-ACDS panel were compared with sensitivities to a panel of 122 standard chemotherapy agents, the most striking relationship was a strong negative correlation (r = -0.3) between basal BCL-X levels and sensitivity to drugs in all of the mechanistic classes except one class of antimetabolites. Sensitivities to a maximally diverse sample of 1200 from 70,000 compounds tested in the NCI-ACDS of agents were also negatively correlated with BCL-X levels. A novel application of factor analysis revealed that the newly discovered associations were independent of previously demonstrated sensitivity factors such as p53 mutation status and native population doubling time. A similar pattern of correlation was seen for Bcl-X(L) protein levels. Conversely, BAX and BCL2, two other genes associated with regulation of apoptosis, showed no overall correlation with drug sensitivities. This suggests that BCL-X may play a unique role in general resistance to cytotoxic agents, with the cell lines demonstrating relative resistance to 70,000 cytotoxic agents in the NCI-ACDS being characterized by high BCL-X expression.
Continuous Transversus Abdominis Plane Block for Primary Open Inguinal Hernia Repair: A Randomized, Double-Blind, Placebo-Controlled Trial (2019)

Continuous transversus abdominis plane blocks provide modest improvements in pain after open inguinal hernia repair but fail to significantly reduce opioid consumption or improve functional activity levels in the setting of multimodal analgesia use.
Hyperoxia causes decreased expression of vascular endothelial growth factor and endothelial cell apoptosis in adult retina (1999)

Mice or humans with photoreceptor degenerations experience permeability and dropout of retinal capillaries. Loss of photoreceptors results in decreased oxygen usage and thinning of the retina with increased oxygen delivery to the inner retina. To investigate the possibility that increased tissue oxygen plays a role in the vascular damage, we exposed adult mice to hyperoxia, which also increases oxygen in the retina. After 1, 2, or 3 weeks of hyperoxia, there was a statistically significant decrease in retinal vascular density that was not reversible, and endothelial cell apoptosis was demonstrated by TUNEL staining. Mice exposed to hyperoxia and mice with photoreceptor degeneration both showed decreased expression of VEGF in the retina. After complete or near-complete degeneration of photoreceptors, there was increased expression of VEGF in RPE cells, which may explain the association of photoreceptor degeneration and neovascularization in or around the RPE. Increased expression of VEGF in photoreceptors of transgenic mice failed to prevent hyperoxia-induced retinal capillary dropout. These data suggest that increased oxygen in the retina, either by increased inspired oxygen or by photoreceptor degeneration, results in endothelial cell death and dropout of capillaries. Decreased expression of VEGF may be a contributing factor, but the situation may be more complicated for mature retinal vessels than it is for immature vessels, because VEGF replacement does not rescue mature retinal vessels, suggesting that other factors may also be involved. J. Cell. Physiol. 179:149–156, 1999. © 1999 Wiley-Liss, Inc.
International Multi-Site Initiative to Develop an MRI-Inclusive Nomogram for Side-Specific Prediction of Extraprostatic Extension of Prostate Cancer (2021)

In an international, multi-site study, we developed an MRI-inclusive nomogram for the side-specific prediction of EPE of prostate cancer that demonstrated significantly greater accuracy than clinical benchmark models.
Enabling rapid X-ray CT characterisation for additive manufacturing using CAD models and deep learning-based reconstruction (2023)

Abstract Metal additive manufacturing (AM) offers flexibility and cost-effectiveness for printing complex parts but is limited to few alloys. Qualifying new alloys requires process parameter optimisation to produce consistent, high-quality components. High-resolution X-ray computed tomography (XCT) has not been effective for this task due to artifacts, slow scan speed, and costs. We propose a deep learning-based approach for rapid XCT acquisition and reconstruction of metal AM parts, leveraging computer-aided design models and physics-based simulations of nonlinear interactions between X-ray radiation and metals. This significantly reduces beam hardening and common XCT artifacts. We demonstrate high-throughput characterisation of over a hundred AlCe alloy components, quantifying improvements in characterisation time and quality compared to high-resolution microscopy and pycnometry. Our approach facilitates investigating the impact of process parameters and their geometry dependence in metal AM.
Chiral recognition in the synthesis of dimetalla-4-tert-butylcalix[8]arene complexes. The incorporation of a metal-alkoxide ligand into a molecular cavity (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChiral recognition in the synthesis of dimetalla-4-tert-butylcalix[8]arene complexes. The incorporation of a metal-alkoxide ligand into a molecular cavityGretchen E. Hofmeister, F. Ekkehardt Hahn, and Steven F. PedersenCite this: J. Am. Chem. Soc. 1989, 111, 6, 2318–2319Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://pubs.acs.org/doi/10.1021/ja00188a064https://doi.org/10.1021/ja00188a064research-articleACS PublicationsRequest reuse permissionsArticle Views308Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
ChemInform Abstract: Enantioselective, Catalytic Trichloromethylation Through Visible‐Light‐Activated Photoredox Catalysis with a Chiral Iridium Complex. (2016)

Abstract This is the first example of an enantioselective, catalytic trichloromethylation process.