gebhart/patrepeval huggingface dataset:
rs73185306 C/T Is Not a Predisposing Risk Factor for Inherited Chromosomally Integrated Human Herpesvirus 6A/B (2019)

Approximately 1% of people worldwide carry a copy of the human herpesvirus 6A or 6B (HHV-6A/B) in every cell of their body. This condition is referred to as inherited chromosomally integrated HHV-6A/B (iciHHV-6A/B). The mechanisms leading to iciHHV-6A/B chromosomal integration are yet to be identified. A recent report suggested that the rs73185306 C/T single-nucleotide polymorphism (SNP) represents a favorable predisposing factor leading to HHV-6A/B integration. After genotype analysis of an independent cohort (N = 11 967), we report no association between the rs73185306 C/T SNP and HHV-6A/B chromosomal integration (odds ratio, 0.90 [95% confidence interval, .54-1.51]; P = .69).
A generic scheme for building overlay networks in adversarial scenarios (2004)

This paper presents a generic scheme for a central, yet untackled issue in overlay dynamic networks: maintaining stability over long life and against malicious adversaries. The generic scheme maintains desirable properties of the underlying structure including low diameter, and efficient routing mechanism, as well as balanced node dispersal. These desired properties are maintained in a decentralized manner without resorting to global updates or periodic stabilization protocols even against an adaptive adversary that controls the arrival and departure of nodes.
Recombinant human interleukin 6 is a potent inducer of the acute phase response and elevates the blood platelets in nonhuman primates. (1991)

Human interleukin 6 (IL-6) produced by molecular cloning was administered to nonhuman primates to assess its biological activities in vivo. Rhesus monkeys were treated s.c. with recombinant human (rh) IL-6 at 3 and 30 micrograms/kg body weight/day for 11 days, followed by the administration of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) at 5.5 micrograms/kg/day for 5 days. Serum levels of positively regulated acute phase proteins (APP) (C-reactive protein, alpha 1-antitrypsin, haptoglobin, and ceruloplasmin) increased, whereas negatively regulated APP (prealbumin) decreased in response to rhIL-6 treatment in a dose-dependent manner. Platelet counts rose after a latent period of 4-5 days following the start of rhIL-6 treatment, resulting in a maximum twofold increase above normal levels 2-3 days after the termination of the rhIL-6 treatment. Recombinant human IL-6 treatment induced a two to threefold rise in myeloid progenitor blood cell levels. The subsequent administration of rhGM-CSF to rhIL-6-pretreated animals did not increase the progenitor cell levels in blood above those found with rhGM-CSF treatment alone, indicating that rhIL-6 compared to recombinant human interleukin 3 (rhIL-3) has a minor proliferative effect on hematopoietic precursors in vivo. In conclusion, rhIL-6 was shown to be a potent stimulator of APP and was able to increase the number of platelets in circulation in nonhuman primates.
Structure–Activity Relationships for the N-Me- Versus N-H-Amide Modification to Macrocyclic ent-Verticilide Antiarrhythmics (2022)

The synthesis of all <i>N</i>-Me and <i>N</i>-H analogues of <i>ent</i>-verticilide is described, enabling a structure-activity relationship study based on cardiac ryanodine receptor (RyR2) calcium ion channel inhibition. The use of permeabilized cardiomyocytes allowed us to correlate the degree of <i>N</i>-methylation with activity without concern for changes in passive membrane permeability that these modifications can cause. A key hypothesis was that the minimal pharmacophore may be repeated in this cyclic oligomeric octadepsipeptide (a 24-membered macrocycle), opening the possibility that target engagement will not necessarily be lost with a single <i>N</i>-Me → <i>N</i>-H modification. The effect in the corresponding 18-membered ring oligomer (<i>ent</i>-verticilide B1) was also investigated. We report here that a high degree of <i>N</i>-methyl amide content is critical for activity in the <i>ent</i>-verticilide series but not entirely so for the <i>ent</i>-verticilide B1 series.
Status and prospect of oil recovery from oily sludge:A review (2020)

Oily sludge is a kind of solid emulsified waste produced by the petroleum industry. It is generally composed of water, crude oil, and solid particulate matter. Because it contains large amounts of cycloalkanes, benzene series, polycyclic aromatic hydrocarbons, and other toxic and harmful substances, it poses a substantial threat to human health and the surrounding environment; therefore, it must be treated to reduce its toxicity. However, a large component of oily sludge is crude oil, which has great recycling value. Therefore, various crude oil recovery technologies, such as solvent extraction, pyrolysis, centrifugation, ultrasonic treatment, electronal treatment, flotation, supercritical treatment, and combined processes, have been developed for the treatment of oily sludge. The main purpose of this review is to discuss the development of these recycling technologies and to summarize and compare their advantages, disadvantages, and mechanisms of action. On this basis, the future development direction of recycling technology is prospected.
Expression of Lewisa, Lewisb, X, and Y blood group antigens in human colonic tumors and normal tissue and in human tumor-derived cell lines. (1986)

Serological and immunopathological analysis of the expression of Lea, Leb, X, and Y blood group antigens on cell lines and tissues was performed using a panel of mouse monoclonal antibodies. The distribution of the antigens was determined on 155 malignant tumor cell lines of various types and 10 short term cultures of normal fibroblasts and kidney cells. Among colon cancers, all four blood group antigens were expressed on the majority of cell lines. On lung, breast, bladder, and ovarian cancer cell lines, X and Y antigens were the main specificities found, whereas few of the renal and hematopoietic tumor cell lines demonstrated any of the four blood group antigens. No blood group antigens could be detected on astrocytoma or melanoma cell lines. The expression of the antigens was also analyzed on frozen sections of colon carcinoma and adjacent normal colon tissue from 42 patients using the immunoperoxidase method. Lea and X were detected throughout the normal colon and on most colonic tumors. In poorly differentiated colon cancer and in metastatic cancer, decrease of Lea antigen was observed. Leb and Y expression was observed in only 20-45% of normal tissue samples but in almost all colonic carcinoma tissues. A selected number of tumor and normal specimens from patients whose secretor status was known were examined in more detail. Both the staining of the tissues and the reactivity of blood group glycolipids from the same specimens were determined. These studies confirmed the above findings and demonstrated the unexpected ability of tumors of nonsecretors to express Leb and/or Y antigens. In such individuals, in whom the expression of Leb and Y antigens in normal tissues is absent or minimal, these antigens provide possible targets for immunodiagnosis and therapy.
The cellular structure of the female reproductive system of Meloidogyne spp. compared with other nematode species (2002)

Gonads from living young females, belonging to 15 Meloidogyne species and 80 other species, were extruded to study the cellular structure of the female genital structure. Within the genus Meloidogyne, the spermatheca is always spherical and formed by a variable number of thick, lobe-like cells, which makes it different from any other known nematode genus. Members of this genus are strongly unified by this characteristic anatomical feature. Nevertheless a remarkable intrageneric variability is demonstrated; most species have 16 to 18 spermatheca cells with interlaced cell boundaries while M. microtyla and M. ichinohei have more spermatheca cells with atypical cell boundaries and the spermatheca cells of the M. fallax specimens are clustered together forming lobes. While most species were studied with light microscopy, the gonads of M. incognita were studied thoroughly using scanning and transmission electron microscopy. This allowed us to exactly determine the structural separate gonoduct components and have a better insight in their action and function.
Serum IGF-1 concentrations in a sample of patients with traumatic brain injury as a diagnostic marker of growth hormone secretory response to glucagon stimulation testing (2010)

Our current findings are consistent with previous work assessing peak GH response using the insulin tolerance test (ITT) in a non-TBI sample, suggesting that diagnostic accuracy may be optimized if the GST is used when obtained serum IGF-1 concentrations are below 175 μg/l. While the decision to perform provocative testing to assess GHD in adult patients should be based on the clinician's clinical impression, the findings from this retrospective study can provide useful clinical information and serve as a guide.
CHLORBUTOL TOXICITY AND DEPENDENCE (1979)

A case of chlorbutol toxicity and dependence is presented. A very long elimination half-life (13.2 days) was found in the patient. The data suggest that chlorbutol is an unsuitable sedative to be available freely to the public.
Prevention of Bladder Cancer: A Review (2005)

While many agents hold promise in the prevention of bladder cancer, none currently can be recommended as proven chemoprevention strategies. Improving the accuracy of patient risk assessment and identification of surrogate endpoint biomarkers are crucial to the testing of these strategies. Efficient study design will ensure rapid and substantial advances in the chemoprevention of bladder cancer.
Towards Maude 2.0 (2000)

Maude 2.0 is the new version of the Maude rewriting logic language currently under development. Maude 2.0's three main goals are: (i) greater generality and expressiveness; (ii) efficient support for a wider range of programming applications; and (iii) usability as a key component for developing internet programming and mobile computing systems. To meet these goals, a number of new features have been added. The membership equational logic of functional modules and the rewriting logic of system modules are now supported in their greatest possible generality, and the operational semantics of object-oriented modules guarantees object and message fairness. Module operations in Full Maude are also more general thanks to parameterized theories and views. Efficient support for a wider range of programming applications is provided both by the Maude compiler—which can reach up to 15 million rewrites per second on a 667MHz Xeon—and by a library of new built-in modules. Besides new built-in functional modules, a key new feature is built-in object-oriented modules that provide flexible interaction with external objects such as file systems, window systems, and internet sockets. In particular, built-in internet sockets will provide excellent support for a new declarative style of internet programming in Maude, and will be used as a key building block to implement the Mobile Maude language.
Modulation of apoptosis-associated genes bcl-2, bcl-x, and bax during rat liver regeneration. (1996)

Liver regeneration (LR) after 70% partial hepatectomy (PH) represents a unique in vivo model of cell cycle and gene regulation. This study was conducted to characterize apoptosis-associated gene expression during LR. The results indicated that transcripts for both bcl-x and bcl-2 exhibited similar patterns of expression during LR with peaks at 6 h post-PH. In contrast, the major 1.1-kb bax transcript exhibited peaks at 18 (P < 0.05) and 72 h (P < 0.001) post-PH. Nuclear run-on analyses for all three genes indicated no detectable transcription rate changes during LR. At 6 h post-PH, when bcl-x mRNA levels were increased by 25-fold (P < 0.001), bcl-x mRNA half-life was elevated 4-fold (P < 0.001). Similarly, bax transcript half-life increased from 2.8 h at 0 h to 4.3 h at 24 h (P < 0.001) and > 8 h at 40 h (P < 0.001) post-PH, coincident with increases in steady-state levels of mRNA. Western blot analyses of Bcl-2 and Bcl-x proteins showed no significant change through 96 h of LR, whereas Bax protein levels cycled in parallel with its mRNA. Interestingly, novel Bax- and Bcl-2-cross-reactive proteins of 31 and 32 kDa, respectively, were detected in nuclei isolated from quiescent liver. When liver growth was induced by the peroxisome proliferator clofibrate, transcript and protein levels were coupled for bcl-x but not for bax. In conclusion, the apoptosis-associated genes bcl-2, bcl-x and bax are modulated at the transcript and protein levels during LR, suggesting a role for these gene products in normal liver growth. The alterations in transcript levels occur posttranscriptionally and involve changes in mRNA stability. Furthermore, unlike bax, steady-state protein and transcript levels are uncoupled for both bcl-2 and bcl-x, suggesting a role for translational regulation during LR after PH.
The Epidemiology of Children Hospitalized With Herpes Zoster in Canada (2008)

Immunocompromised children represented the overwhelming majority of IMPACT hospitalized cases. Complications directly resulting from HZ were common in immunocompetent children. As varicella vaccine use becomes more widespread, the IMPACT network will continue to play an important role in monitoring the changing epidemiology of HZ in children.
ChemInform Abstract: A General Strategy for the Synthesis of Enantiomerically Pure Azetidines and Aziridines Through Nickel‐Catalyzed Cross‐Coupling. (2015)

ChemInformVolume 46, Issue 40 Heterocyclic Compounds ChemInform Abstract: A General Strategy for the Synthesis of Enantiomerically Pure Azetidines and Aziridines Through Nickel-Catalyzed Cross-Coupling. Kim L. Jensen, Kim L. Jensen Dep. Chem., MIT, Cambridge, MA 02139, USASearch for more papers by this authorDennis U. Nielsen, Dennis U. Nielsen Dep. Chem., MIT, Cambridge, MA 02139, USASearch for more papers by this authorTimothy F. Jamison, Timothy F. Jamison Dep. Chem., MIT, Cambridge, MA 02139, USASearch for more papers by this author Kim L. Jensen, Kim L. Jensen Dep. Chem., MIT, Cambridge, MA 02139, USASearch for more papers by this authorDennis U. Nielsen, Dennis U. Nielsen Dep. Chem., MIT, Cambridge, MA 02139, USASearch for more papers by this authorTimothy F. Jamison, Timothy F. Jamison Dep. Chem., MIT, Cambridge, MA 02139, USASearch for more papers by this author First published: 17 September 2015 https://doi.org/10.1002/chin.201540115Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume46, Issue40October, 2015 RelatedInformation
PML Implementation in a Nonconforming Mixed-Element DGTD Method for Periodic Structure Analysis (2019)

A nonconforming mixed-element (tetrahedral/hexahedral) discontinuous Galerkin time-domain (DGTD) method with a perfectly matched layer (PML) absorber is proposed to analyze the electromagnetic scattering from doubly periodic structures. An efficient auxiliary differential equation (ADE)-based PML implementation is presented with transformed field variables introduced by the time-domain periodic boundary conditions (PBCs). The proposed PML implementation performs well in absorbing the waves with high-order Floquet modes. Additionally, a mixed-order DGTD method is introduced to improve the proposed PML implementation's long-term stability and reduce the total computational cost. Based on the mixed tetrahedral and hexahedral grids, the nonconforming DGTD method can provide accurate field distribution near complex scattering geometries while simultaneously reducing the degrees of freedom (DoF) in the rest of the computational domain, including the open space and PML regions. Finally, electromagnetic simulations are presented to demonstrate the applicability, accuracy, and efficiency of the proposed method.
Efficient 340-nm light generation by a ridge-type waveguide in a first-order periodically poled MgO:LiNbO_3 (2003)

Quasi-phase-matched (QPM) UV second-harmonic generation (SHG) in a periodically poled MgO:LiNbO3 waveguide is presented. A ridge-type waveguide with high nonlinearity and strong resistance to photorefractive damage was achieved by use of an ultraprecision machining technique. By use of this waveguide in 1.4-microm periodically poled MgO:LiNbO3, a first-order QPM SHG device for 340-nm UV radiation was demonstrated. In a single-pass configuration, continuous-wave 22.4-mW UV light was generated for a fundamental power of 81 mW, corresponding to a normalized conversion efficiency of 340%/W.
Use Cases for DDoS Open Threat Signaling (2021)

The DDoS Open Threat Signaling (DOTS) effort is intended to provide
protocols to facilitate interoperability across disparate DDoS
mitigation solutions. This document presents use cases which describe
the interactions expected between the DOTS components as well as DOTS
messaging exchanges. These use cases are meant to identify the
interacting DOTS components, how they collaborate and what are the
typical information to be exchanged.
Low-Cost, Low-Maintenance Rearing of Maggots in Hospitals, Clinics, and Schools (1996)

With the recent resurgence in the interest and use of maggot therapy, blow fly rearing can be expected to increase. The rearing of these necrophagous flies is technically simple, but can be expensive, malodorous, and wasteful of space. Although there are numerous references to maggot rearing in the older literature, they do not adequately address these specific problems. Therefore, we describe several of the simple, low-cost, and unobtrusive strategies for rearing blow flies that have proven useful in our hospital-based insectary.
Joint Optimization of 3D Placement and Radio Resource Allocation for per-UAV Sum Rate Maximization (2023)

Unmanned aerial vehicles (UAV) have emerged as a practical solution that provides on-demand services to users in areas where the terrestrial network is non-existent or temporarily unavailable, e.g., due to natural disasters or network congestion. In general, UAVs' user-serving capacity is typically constrained by their limited battery life and the finite communication resources that highly impact their performance. This work considers the orthogonal frequency division multiple access (OFDMA) enabled multiple unmanned aerial vehicles (multi-UAV) communication systems to provide on-demand services. The main aim of this work is to derive an efficient technique for the allocation of radio resources, $3$D placement of UAVs, and user association matrices. To achieve the desired objectives, we decoupled the original joint optimization problem into two sub-problems: (i) $3$D placement and user association and (ii) sum-rate maximization for optimal radio resource allocation, which are solved iteratively. The proposed iterative algorithm is shown via numerical results to achieve fast convergence speed after fewer than 10 iterations. The benefits of the proposed design are demonstrated via superior sum-rate performance compared to existing reference designs. Moreover, results showed that the optimal power and sub-carrier allocation help to mitigate the inter-cell interference that directly impacts the system's performance.
Lessons Learned: From Dye‐Sensitized Solar Cells to All‐Solid‐State Hybrid Devices (2014)

The field of solution-processed photovoltaic cells is currently in its second spring. The dye-sensitized solar cell is a widely studied and longstanding candidate for future energy generation. Recently, inorganic absorber-based devices have reached new record efficiencies, with the benefits of all-solid-state devices. In this rapidly changing environment, this review sheds light on recent developments in all-solid-state solar cells in terms of electrode architecture, alternative sensitizers, and hole-transporting materials. These concepts are of general applicability to many next-generation device platforms.
Skin biopsy in Lafora disease (2003)

Lafora disease is characterized by pathognomonic inclusions, Lafora bodies (LB), in neurons and other cell types. In skin, LB have been reported in either eccrine sweat glands or in apocrine sweat glands. The disease is caused by mutations in either the EPM2A gene or in a second yet-unknown gene. Here the authors determine whether a genotype-phenotype correlation exists between the genetic form of the disease and the skin cell type affected by LB formation. Also is described an important source of false positivity in the use of axillary biopsies for disease diagnosis.
Quasi-Synchronous Random Access for Massive MIMO-Based LEO Satellite Constellations (2023)

Low earth orbit (LEO) satellite constellation-enabled communication networks are expected to be an important part of many Internet of Things (IoT) deployments due to their unique advantage of providing seamless global coverage. In this paper, we investigate the random access problem in massive multiple-input multiple-output-based LEO satellite systems, where the multi-satellite cooperative processing mechanism is considered. Specifically, at edge satellite nodes, we conceive a training sequence padded multi-carrier system to overcome the issue of imperfect synchronization, where the training sequence is utilized to detect the devices' activity and estimate their channels. Considering the inherent sparsity of terrestrial-satellite links and the sporadic traffic feature of IoT terminals, we utilize the orthogonal approximate message passing-multiple measurement vector algorithm to estimate the delay coefficients and user terminal activity. To further utilize the structure of the receive array, a two-dimensional estimation of signal parameters via rotational invariance technique is performed for enhancing channel estimation. Finally, at the central server node, we propose a majority voting scheme to enhance activity detection by aggregating backhaul information from multiple satellites. Moreover, multi-satellite cooperative linear data detection and multi-satellite cooperative Bayesian dequantization data detection are proposed to cope with perfect and quantized backhaul, respectively. Simulation results verify the effectiveness of our proposed schemes in terms of channel estimation, activity detection, and data detection for quasi-synchronous random access in satellite systems.
Decoupling of Two Closely‐Spaced Planar Monopole Antennas Using Two Novel Printed‐Circuit Structures (2018)

Abstract A new approach is presented in this paper to reduce mutual coupling between two closely‐spaced planar monopole antennas. The approach employs either two parallel metallic strips or a single strip with a meander‐shaped slotted pattern symmetrically placed between the two antennas with their edges being separated by 4 mm and 8 mm, respectively. The novel aspect of our approach is that the decoupling structures are not only confined in the space shared by the two planar monopole edges but are rather extended above the partial ground plane on one end and to the edge of the substrate on the other end. The design provided measured −10 dB impedance and − 20 dB decoupling bandwidths extending from 1.65 GHz to 4 GHz, and 1.43 GHz to 3.7 GHz, respectively, and the measured realized gains at 2.45 GHz are 3.81 dBi and 2.14 dBi, respectively. The proposed arrays offer excellent MIMO performance in terms of envelope correlation coefficient and link efficiency in realistic MIMO propagation environments through the decoupled frequency regimes.