gebhart/patrepeval huggingface dataset:
Data from Association of Tissue Abiraterone Levels and <i>SLCO</i> Genotype with Intraprostatic Steroids and Pathologic Response in Men with High-Risk Localized Prostate Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Germline variation in solute carrier organic anion (&lt;i&gt;SLCO&lt;/i&gt;) genes influences cellular steroid uptake and is associated with prostate cancer outcomes. We hypothesized that, due to its steroidal structure, the CYP17A inhibitor abiraterone may undergo transport by &lt;i&gt;SLCO&lt;/i&gt;-encoded transporters and that &lt;i&gt;SLCO&lt;/i&gt; gene variation may influence intracellular abiraterone levels and outcomes.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Steroid and abiraterone levels were measured in serum and tissue from 58 men with localized prostate cancer in a clinical trial of LHRH agonist plus abiraterone acetate plus prednisone for 24 weeks prior to prostatectomy. Germline DNA was genotyped for 13 SNPs in six &lt;i&gt;SLCO&lt;/i&gt; genes.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Abiraterone levels spanned a broad range (serum median 28 ng/mL, 108 nmol/L; tissue median 77 ng/mL, 271 nmol/L) and were correlated (&lt;i&gt;r&lt;/i&gt; = 0.355, &lt;i&gt;P&lt;/i&gt; = 0.001). Levels correlated positively with steroids upstream of CYP17A (pregnenolone, progesterone), and inversely with steroids downstream of CYP17A (DHEA, AED, testosterone). Serum PSA and tumor volumes were higher in men with undetectable versus detectable tissue abiraterone at prostatectomy (median 0.10 vs. 0.03 ng/dL, &lt;i&gt;P&lt;/i&gt; = 0.02; 1.28 vs. 0.44 cc, &lt;i&gt;P&lt;/i&gt; = 0.09, respectively). SNPs in &lt;i&gt;SLCO2B1&lt;/i&gt; associated with significant differences in tissue abiraterone (rs1789693, &lt;i&gt;P&lt;/i&gt; = 0.0008; rs12422149, &lt;i&gt;P&lt;/i&gt; = 0.03) and higher rates of minimal residual disease (tumor volume &lt; 0.5 cc; rs1789693, 67% vs. 27%, &lt;i&gt;P&lt;/i&gt; = 0.009; rs1077858, 46% vs. 0%, &lt;i&gt;P&lt;/i&gt; = 0.03). LNCaP cells expressing SLCO2B1 showed two- to fourfold higher abiraterone levels compared with vector controls (&lt;i&gt;P&lt;/i&gt; &lt; 0.05).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Intraprostatic abiraterone levels and genetic variation in &lt;i&gt;SLCO&lt;/i&gt; genes are associated with pathologic responses in high-risk localized prostate cancer. Variation in &lt;i&gt;SLCO&lt;/i&gt; genes may serve as predictors of response to abiraterone treatment. &lt;i&gt;Clin Cancer Res; 23(16); 4592–601. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Exploiting on-chip inductance in high speed clock distribution networks (2005)

On-chip inductance effects. can be used to improve the performance of high speed integrated circuits. Specifically, inductance can improve the signal slew rate (the rise time), virtually eliminate short-circuit power consumption, and reduce the area of the active devices and repeaters inserted to optimize the performance of long interconnects. These positive effects suggest the development of design strategies that benefit from on-chip inductance. An example of an industrial clock distribution network is presented to illustrate the process in which inductance can be used to improve the performance of high speed integrated circuits.
X-ray study of Ta(CHCMe3)(S-2,4,6-C6H2-iso-Pr3)3(SEt2) suggests why it is inactive for metathesis of ordinary olefins (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTX-ray study of Ta(CHCMe3)(S-2,4,6-C6H2-iso-Pr3)3(SEt2) suggests why it is inactive for metathesis of ordinary olefinsKevin C. Wallace, William M. Davis, and Richard R. SchrockCite this: Inorg. Chem. 1990, 29, 5, 1104–1106Publication Date (Print):March 1, 1990Publication History Published online1 May 2002Published inissue 1 March 1990https://doi.org/10.1021/ic00330a041RIGHTS & PERMISSIONSArticle Views59Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Dielectrophoretic cell sorting via sliding cells on 3D silicon microelectrodes (2017)

This work presents an innovative design for a flow-through dielectrophoretic cell sorting based on silicon bulk microelectrodes featuring sidewall undercuts. The microelectrodes are configured into an interdigitated array with digits extending across the flow chamber at an oblique angle against the flow stream. Target cells under dielectrophoretic forces and hydrodynamic drag can slide along the digits to a dedicated outlet. The design has been showcased for continuous-flow sorting of viable and non-viable mammalian cells, achieving a throughput of 16,600 cells/min, an order of magnitude higher than those reported for existing continuous-flow cell sorting designs using thin-film or volumetric microelectrodes.
The Association Between Avulsions of the Reflected Head of the Rectus Femoris and Labral Tears (2013)

Level 4, retrospective case series.
Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity (2016)

Induction of trained immunity (innate immune memory) is mediated by activation of immune and metabolic pathways that result in epigenetic rewiring of cellular functional programs. Through network-level integration of transcriptomics and metabolomics data, we identify glycolysis, glutaminolysis, and the cholesterol synthesis pathway as indispensable for the induction of trained immunity by β-glucan in monocytes. Accumulation of fumarate, due to glutamine replenishment of the TCA cycle, integrates immune and metabolic circuits to induce monocyte epigenetic reprogramming by inhibiting KDM5 histone demethylases. Furthermore, fumarate itself induced an epigenetic program similar to β-glucan-induced trained immunity. In line with this, inhibition of glutaminolysis and cholesterol synthesis in mice reduced the induction of trained immunity by β-glucan. Identification of the metabolic pathways leading to induction of trained immunity contributes to our understanding of innate immune memory and opens new therapeutic avenues.
Spectroscopic Investigation on Cr3+→Nd3+ Energy Transfer in glasses (1991)

The Cr3+→Nd3+ energy transfer is not succeeded. What is the reason? S. Stokowkii attributed the reason to the back energy trnasfer from Cr3+ to Nd3+. In this paper, we investigated the processes of energy transfer and back energy transfer from Cr3−to Nd3+ and examined the possibility whether the Cr3+→Nd3+ energy transfer probability can be improved in glass.
Performance improvement in AC-AC SCR controller (2002)

Standard use of AC SCR controllers is for starting induction motors. However, the reduction of the starting torque has limited its application to no load starters. This paper uses a novel technique to expand the range of application of AC SCR controllers. The technique increases the frequency in discrete steps until the line frequency is reached. These discrete steps are sub-multiples of the line frequency. The subfrequencies are generated by the omission or inclusion of line frequency half cycles. The sequence voltages are predefined for each sub-multiple of the frequency. In order to obtain positive torque for all the sub-frequencies, the system is properly unbalanced. This strategy allows a start similar to the one achieved by the inverters, and additionally allows low speed motor operation with high torque. The system is complemented with a control of constant impedance for minimization of the reactive power when the motor operates in sub-load. Performance testing of the actual system has shown good results, confirming it as an optional and cheaper alternative for starting-loaded induction motors with low RMS current.
Magnetic Resonance Imaging of (2015)

This study explores the hypothesis that Magnetic Resonance Imaging (MRI) can image the process of electrolysis by detecting pH fronts. The study has relevance to real time control of cell ablation with electrolysis. To investigate the hypothesis we compare the following MR imaging sequences: T1 weighted, T2 weighted and Proton Density (PD), with optical images acquired using pH-sensitive dyes embedded in a physiological saline agar solution phantom treated with electrolysis and discrete measurements with a pH microprobe. We further demonstrate the biological relevance of our work using a bacterial E. Coli model, grown on the phantom. The results demonstrate the ability of MRI to image electrolysis produced pH changes in a physiological saline phantom and show that these changes correlate with cell death in the E. Coli model grown on the phantom. The results are promising and invite further experimental research. I n a biomedical context, electrolysis refers to the passage of low magnitude, direct current between two electrodes through a living tissue. Electrolytic ablation is the application of electrolysis for inducing irreversible damage to undesired tissues, and research into the biochemical/biophysical aspects of tissue electrolysis can be traced to the 19 th century 1 . In modern medicine, the tools available for tissue ablation are based on various
A New Catalyst for Highly Syndiospecific Living Olefin Polymerization:  Homopolymers and Block Copolymers from Ethylene and Propylene (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA New Catalyst for Highly Syndiospecific Living Olefin Polymerization: Homopolymers and Block Copolymers from Ethylene and PropyleneJun Tian, Phillip D. Hustad, and Geoffrey W. CoatesView Author Information Department of Chemistry and Chemical Biology Baker Laboratory, Cornell University Ithaca, New York 14853 Cite this: J. Am. Chem. Soc. 2001, 123, 21, 5134–5135Publication Date (Web):May 4, 2001Publication History Received23 February 2001Revised8 April 2001Published online4 May 2001Published inissue 1 May 2001https://pubs.acs.org/doi/10.1021/ja0157189https://doi.org/10.1021/ja0157189rapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views3622Altmetric-Citations372LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alkyls,Catalysts,Copolymers,Hydrocarbons,Polymers Get e-Alerts
Supplementary Table 2 from Whole-Genome and Transcriptional Analysis of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer Demonstrates Intraclass Heterogeneity (2023)

&lt;p&gt;Supplementary Table 2. Clinical Characteristics of the Evaluable Paired Biopsy Cohort&lt;/p&gt;
Multiuser detection in single-path fading channels (1994)

The performance analysis of maximum likelihood sequence and decorrelating multiuser detectors is developed for the single-path Rayleigh fading channel. The received signal in this multipoint-to-point channel is additively composed of white Gaussian noise and independently faded waveforms from a finite number of asynchronous users. The optimum sequence detector consists of a bank of single-user matched filters followed by a dynamic programming algorithm, has a demodulation complexity per symbol which is exponential in the number of users, and requires the knowledge of the system as well of the fading parameters. The decorrelating detector has a complexity which is polynomial in the number of users, and does not require knowledge of the signal amplitudes, which are assumed to vary slowly relative to the symbol rate. The single-user error rates are presented for both detectors and compared to conventional detection and isolated transmission, and the notion of asymptotic multiuser efficiency is developed for this channel. In contrast to conventional detection; which suffers from near-far effects due to Rayleigh fading, it is shown that the aforementioned multiuser detectors exhibit performance which rivals that of isolated transmission for sufficiently small thermal noise power. The results of the analysis are illustrated with numerical examples and indicate that the near-far problem may be alleviated by a more sophisticated receiver design.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Seed biology and technology: At the crossroads and beyond. Introduction to the Symposium on Seed Biology and Technology: Applications and Advances and a prospectus for the future (1998)

The papers in this special section of Seed Science Research are products of a symposium on Seed Biology and Technology: Applications and Advances, held in Fort Collins, Colorado, on 13–16 August, 1997. The symposium was convened as a cooperative effort of Regional Research Project W-168 within the United States Department of Agriculture (USDA) Cooperative States Research, Extension and Education Service (CSREES) system. Regional Research Projects are authorized by the Hatch Act, which established the Agricultural Experiment Station (AES) system in the United States (US Code). This is a system in which land-grant institutions in each state conduct research and education programmes relevant to agriculture, the environment and society. Regional Research projects are a mechanism ‘for cooperative research in which two or more State agricultural experiment stations are cooperating to solve problems that concern the agriculture of more than one state.’ Such projects ‘can provide the solution to a problem of fundamental importance or fill an important gap in our knowledge from the standpoint of the present and future agriculture of the region’
Messung von Nutzerinteraktion mit einem Exoskelett durch EMG und Gelenk-Drehmomente (2018)

Zusammenfassung Die Bestimmung der Bewegungsintention stellt eine Herausforderung in der Mensch-Roboter-Kooperation dar, um einen sicher und intuitvive Bedienung zu ermöglichen. Hierzu werden zwei Messprinzipen zur Nutzerintentionserkennung mit einem Oberarm-Exoskelett untersucht. Für die Antriebsachsen wird ein strukturintegrierter Drehmomentsensor entworfen und über ein dynamisches Modell unter Berücksichtigung der Schwerkraft, Trägheit und Reibung des Exoskelettes das Nutzermoment bestimmt. Das gemessene Drehmoment wird mit EMG-Signalen der beteiligten Muskeln der Schulter verglichen. Aus Probandenmessungen ist eine Verzögerung des mechanischen Drehmomentes hinter der elektrischen Muskelaktivierung von maximal 80 ms und ein linearer Zusammenhang zwischen Drehmoment und EMG Signal zu erkennen.
Genome-wide patterns of single-feature polymorphism in Arabidopsis thaliana (2007)

We used hybridization to the ATH1 gene expression array to interrogate genomic DNA diversity in 23 wild strains (accessions) of Arabidopsis thaliana (arabidopsis), in comparison with the reference strain Columbia (Col). At <1% false discovery rate, we detected 77,420 single-feature polymorphisms (SFPs) with distinct patterns of variation across the genome. Total and pair-wise diversity was higher near the centromeres and the heterochromatic knob region, but overall diversity was positively correlated with recombination rate (R(2) = 3.1%). The difference between total and pair-wise SFP diversity is a relative measure contrasting diversifying or frequency-dependent selection, similar to Tajima's D, and can be calibrated by the empirical genome-wide distribution. Each unique locus, centered on a gene, has a diversity and selection score that suggest a relative role in past evolutionary processes. Homologs of disease resistance (R) genes include members with especially high levels of diversity often showing frequency-dependent selection and occasionally evidence of a past selective sweep. Receptor-like and S-locus proteins also contained members with elevated levels of diversity and signatures of selection, whereas other gene families, bHLH, F-box, and RING finger proteins, showed more typical levels of diversity. SFPs identified with the gene expression array also provide an empirical hybridization polymorphism background for studies of gene expression polymorphism and are available through the genome browser http://signal.salk.edu/cgi-bin/AtSFP.
Functionalized DNA: A New Replicable Biopolymer We thank Dr. Andreas Marx, University of Bonn, for helpful advice and discussions. This work was supported by the Fonds der Chemischen Industrie, the Karl-Ziegler Stiftung, and the Deutsche Forschungsgemeinschaft. (2001)

New DNA: By enzymatic polymerization of base-modified nucleoside triphosphates, a functionalized DNA (fDNA; see picture) was generated in which every base bears an additional amino acid like residue, thus mimicking the functional group repertoire of peptides on a nucleic acid backbone. These modified oligonucleotides can in turn serve as templates for polymerase chain reaction amplification, thus utilizing fDNA as a novel class of biopolymers for in vitro selection techniques.
Toward a Nanobioinformatics Infrastructure for Nanotechnology-based Prostate Cancer Therapeutic Response Tracking (2007)

Nanobioinformatics is an emerging field of study born out of a necessity of nanotechnology researchers in the life sciences whose work is dependent on timely access to an emerging wealth of data. It brings together the three very diverse fields of nanotechnology, molecular biology and biomedical informatics that until now have had little overlap and where major cultural gaps exist. It is critical that nanobioinformatics be embraced as an extension of biomedical informatics and not be orphaned prematurely. Because of the combinatorial nature of nanoparticle composition (core + surface modifier + payload) and the enthusiasm for this area in general, nanotechnology in biomedicine will see a rapid exponential increase in the data produced, thus making it critical to develop robust infrastructure to support data standardization and storage, modeling and simulation, symbolic reasoning and information retrieval. The goal of the multi-institutional Center for Cancer Nanotechnology Excellence focused on therapy response (CCNE-TR) at Stanford University is to develop a combined ex vivo nanosensor and in vivo molecular imaging approach toward highly sensitive tracking of prostate cancer response to therapy. As a part of this effort, we are developing an informatics platform to serve the diverse needs of this group. In particular, our data portal is designed to support electronic communication and data sharing within the center as well as data and knowledge sharing with the greater scientific community. We are developing this platform to be caBIG compatible integrating a number of different caBIG components that are each the best of breed solution for their particular area. While our approach is designed to meet the needs of our specific center, the methods and infrastructure developed should prove useful for other similar informatics efforts as well.
Introduction to the Special Issue on the 39th European Solid-State Circuits Conference (ESSCIRC) (2014)

The articles in this special issue were presented at the 39th European Solid-State Circuits Conference (ESSCIRC).
Duality of Channel Encoding and Decoding - Part II: Rate-1 Non-binary Convolutional Codes (2018)

This is the second part of a series of papers on a revisit to the bidirectional Bahl-Cocke-Jelinek-Raviv (BCJR) soft-in-soft-out (SISO) maximum a posteriori probability (MAP) decoding algorithm. Part I revisited the BCJR MAP decoding algorithm for rate-1 binary convolutional codes and proposed a linear complexity decoder using shift registers in the complex number field. Part II proposes a low complexity decoder for rate-1 non-binary convolutional codes that achieves the same error performance as the bidirectional BCJR SISO MAP decoding algorithm. We observe an explicit relationship between the encoding and decoding of rate-1 convolutional codes in $GF(q)$. Based on this relationship, the BCJR forward and backward decoding are implemented by dual encoders using shift registers whose contents are vectors of complex numbers. The input to the dual encoders is the probability mass function (pmf) of the received symbols and the output of the dual encoders is the pmf of the information symbols. The bidirectional BCJR MAP decoding is implemented by linearly combining the shift register contents of the dual encoders for forward and backward decoding. The proposed decoder significantly reduces the computational complexity of the bidirectional BCJR MAP algorithm from exponential to linear with constraint length of convolutional codes. To further reduce complexity, fast Fourier transform (FFT) is applied. Mathematical proofs and simulation results are provided to validate our proposed decoder.
Estimation of English and non-English Language Use on the WWW (2000)

The World Wide Web has grown so big, in such an anarchic fashion, that it is difficult to describe. One of the evident intrinsic characteristics of the World Wide Web is its multilinguality. Here, we present a technique for estimating the size of a language-specific corpus given the frequency of commonly occurring words in the corpus. We apply this technique to estimating the number of words available through Web browsers for given languages. Comparing data from 1996 to data from 1999 and 2000, we calculate the growth of a number of European languages on the Web. As expected, non-English languages are growing at a faster pace than English, though the position of English is still dominant.