gebhart/patrepeval huggingface dataset:
Clinical, Molecular, and Immune Analysis of Dabrafenib-Trametinib Combination Treatment for BRAF Inhibitor–Refractory Metastatic Melanoma (2016)

clinicaltrials.gov Identifier: NCT01619774.
Examination of Interactions of Oppositely Charged Proteins in Gels (2007)

Understanding the interactions of proteins with one another serves as an important step for developing faster protein separation methods. To examine protein-protein interactions of oppositely charged proteins, fluorescently labeled albumin and poly-l-lysine were subjected to electrophoresis in agarose gels, in which the cationic albumin and the anionic poly-L-lysine were allowed to migrate toward each other and interact. Fluorescence microscopy was used to image fluorescently tagged proteins in the gel. The secondary structure of the proteins in solution was studied using conventional FTIR spectroscopy. Results showed that sharp interfaces were formed where FITC tagged albumin met poly-L-lysine and that the interfaces did not migrate after they had been formed. The position of the interface in the gel was found to be linearly dependent upon the relative concentration of the proteins. The formation of the interface also depended upon the fluorescent tag attached to the protein. The size of the aggregates at the interface, the fluorescence intensity modifications, and the mobility of the interface for different pore sizes of the gel were investigated. It was observed that the interface was made up of aggregates of about 1 microm in size. Using dynamic light scattering, it was observed that the size of the aggregates that formed due to interactions of oppositely charged proteins depended upon the fluorescent tags attached to the proteins. The addition of small amounts of poly-L-lysine to solutions containing FITC albumin decreased the zeta potential drastically. For this, we propose a model suggesting that adding small amounts of poly-L-lysine to solutions containing FITC -albumin favors the formation of macromolecular complexes having FITC albumin molecules on its surface. Although oppositely charged FITC tagged poly-L-lysine and FITC tagged albumin influence each other's migration velocities by forming aggregates, there were no observable secondary structural modifications when the proteins were mixed in solution.
HPC Programming on Intel Many-Integrated-Core Hardware with MAGMA Port to Xeon Phi (2015)

This paper presents the design and implementation of several fundamental dense linear algebra (DLA) algorithms for multicore with Intel Xeon Phi coprocessors. In particular, we consider algorithms for solving linear systems. Further, we give an overview of the MAGMA MIC library, an open source, high performance library, that incorporates the developments presented here and, more broadly, provides the DLA functionality equivalent to that of the popular LAPACK library while targeting heterogeneous architectures that feature a mix of multicore CPUs and coprocessors. The LAPACK-compliance simplifies the use of the MAGMA MIC library in applications, while providing them with portably performant DLA. High performance is obtained through the use of the high-performance BLAS, hardware-specific tuning, and a hybridization methodology whereby we split the algorithm into computational tasks of various granularities. Execution of those tasks is properly scheduled over the heterogeneous hardware by minimizing data movements and mapping algorithmic requirements to the architectural strengths of the various heterogeneous hardware components. Our methodology and programming techniques are incorporated into the MAGMA MIC API, which abstracts the application developer from the specifics of the Xeon Phi architecture and is therefore applicable to algorithms beyond the scope of DLA.
Synthesis of side chain liquid crystal polymers by living ring-opening metathesis polymerization. 5. Influence of mesogenic group and interconnecting group on the thermotropic behavior of the resulting polymers (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of side chain liquid crystal polymers by living ring-opening metathesis polymerization. 5. Influence of mesogenic group and interconnecting group on the thermotropic behavior of the resulting polymersZen Komiya and Richard R. SchrockCite this: Macromolecules 1993, 26, 6, 1393–1401Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://pubs.acs.org/doi/10.1021/ma00058a031https://doi.org/10.1021/ma00058a031research-articleACS PublicationsRequest reuse permissionsArticle Views282Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Lenvatinib Plus Pembrolizumab in Previously Treated Advanced Endometrial Cancer: Updated Efficacy and Safety From the Randomized Phase III Study 309/KEYNOTE-775 (2023)

<i>Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in</i> JCO <i>or elsewhere, for which the primary end point has already been reported.</i>We report the final prespecified analysis for overall survival (OS), along with updated progression-free survival (PFS) and objective response rate (ORR), and safety from the open-label, randomized, phase III Study 309/KEYNOTE-775. In total, 827 patients with advanced, recurrent, or metastatic endometrial cancer (EC) were randomly assigned to receive lenvatinib 20 mg orally once daily plus pembrolizumab 200 mg intravenously once every 3 weeks (n = 411) or chemotherapy of the treating physician's choice (doxorubicin 60 mg/m<sup>2</sup> intravenously once every 3 weeks or paclitaxel 80 mg/m<sup>2</sup> intravenously once weekly [3 weeks on; 1 week off] [n = 416]). Efficacy was reported for patients with mismatch repair proficient (pMMR) tumors and all-comers, and by subgroups (histology, prior therapy, MMR status). Updated safety was also reported.Lenvatinib plus pembrolizumab showed benefits in OS (pMMR HR, 0.70; 95% CI, 0.58 to 0.83; all-comer HR, 0.65; 95% CI, 0.55 to 0.77), PFS (pMMR HR, 0.60; 95% CI, 0.50 to 0.72; all-comer HR, 0.56; 95% CI, 0.48 to 0.66), and ORR (pMMR patients, 32.4% <i>v</i> 15.1%; all-comers, 33.8% <i>v</i> 14.7%) versus chemotherapy. OS, PFS, and ORR favored lenvatinib plus pembrolizumab in all subgroups of interest. No new safety signals were observed. Lenvatinib plus pembrolizumab continued to show improved efficacy versus chemotherapy and manageable safety in patients with previously treated advanced EC.
Fetal deaths and maternal injury in motor-vehicle crashes using NASS-CDS and CISS field data (2022)

Fetal deaths occurred 19.4-times more often than deaths of pregnant females in a 12-year sample of motor-vehicle crashes. The most common mechanism was a minor crash that resulted in a fetal death without serious injury to the pregnant female and involved side or oblique loading of the pregnant female.
2114 Proposal of a Design Method for Dismantling with Split-Lines (2nd Report) : Determination of the location of split-lines based on interference region (2014)

An important process for the reuse and recycling of end-of-life products is their disassembly. In general, manual disassembly is a labor intensive and costly process. Especially, removing fasteners takes time and cost. This paper proposes a design method for the disassembly of products with split-lines, which enable to destruct a poduct into desired shapes like pull tabs of cans and caps of PET bottles. This method supports a designer to add split-lines to the products in the design phase in order to extract a target component. Especially, this paper proposes a method for determining the location of split-lines by detecting interference regions between components. A case study shows that the dismantling of a LCD TV with split-lines reduces the number of manual operations needed for extracting a target component.
Plasma heating in a solenoid by a relativistic electron beam (1979)

The problem of using powerful relativistic electron beams for a fast heating of plasma in open solenoidal systems has arisen practically immediately after creation of the generators of such beams. As the deceleration length of relativistic electrons due to Coulomb collisions even in a very dense plasma is too large, all the prospects of effective plasma heating with the beams are associated with the collective interaction of a high-current relativistic electron beam with a plasma. The development of the small-scale two-stream instability can be one of the mechanisms for effective deceleration of the relativistic beam in the plasma.
NVMe-over-fabrics performance characterization and the path to low-overhead flash disaggregation (2017)

Storage disaggregation separates compute and storage to different nodes in order to allow for independent resource scaling and thus, better hardware resource utilization. While disaggregation of hard-drives storage is a common practice, NVMe-SSD (i.e., PCIe-based SSD) disaggregation is considered more challenging. This is because SSDs are significantly faster than hard drives, so the latency overheads (due to both network and CPU processing) as well as the extra compute cycles needed for the offloading stack become much more pronounced.
Accurate RF Electrical Characterization of CSPs Using MCM-D Thin Film Technology (2004)

The thin film multilayer multichip module-deposited (MCM-D) technology of IMEC is used for characterising the RF electrical performance of two types of chip scale packages (CSPs). The measurement technique called MCM-on-package-on-MCM (MoPoM) enables accurate measurements and de-embedding in the gigahertz (GHz) range of frequencies. Wafer processing of the MCM-D technology allows for several design structures to be integrated on a single mask. The packages chosen are a 120-pin plastic ball grid array (PBGA) and an 80-pin polymer stud grid array (PSGA). Lumped element models extracted from measurements and three-dimensional simulations show good agreement with the measurements up to 6 GHz for the BGA and the PSGA. The electrical performance of the packages is compared at 1.8 GHz (GSM), 2.4 GHz (Bluetooth), and 5.2 GHz (HiperLAN) and at 5.2 GHz both the packages exhibit a return loss of lower than -10 dB and hence cannot be used in most cases without design improvement. We also show that the influence of encapsulant is significant while transmission line detuning due to the package is not significant at microwave frequencies. We also briefly mention about the crosstalk effects. We demonstrate the significant degradation in the performance of a 5.2 GHz MCM-D low noise amplifier (LNA) after packaging. A significant improvement in package performance is observed by conjugate matching the package interconnects.
Generation of microcellular polyurethane foams via polymerization in carbon dioxide. I: Phase behavior of polyurethane precursors (1996)

Abstract On investigating the generation of microcellular polyurethane foam via reaction in carbon dioxide, we have observed that common polyurethane precursors are CO 2 miscible, whereas typically fluorinated compounds or specially designed surfactants are needed to solubilize polymers in CO 2 . Both isocyanates and polyols are CO 2 ‐miscible at workable pressures and temperatures and in useful concentrations to allow generation of polyurethane foams in CO 2 . By characterizing the phase behavior of several series of propylene oxide and ethylene oxide polyols, we have observed that the combined effects of molecular weight and hydroxyl number fix the location of the phase separation pressures. In general, lower molecular weights and lower hydroxyl mole fractions produce phase boundaries at relatively lower pressures in carbon dioxide. It also has been shown that CO 2 ‐soluble compounds may have a com̀patibilizing effect on less CO 2 ‐soluble materials.
Enzyme electrode-containing sensor for measuring the quantity of a dissolved component, especially glucose (1992)

The aim of the invention is to improve existing amperometric sensors used to measure the quantity of a component present in a solution. This aim is reached by using a sensor provided with a measuring electrode (20) having at least one current collector (37) electrically connected at one of the electric contacts (34) and coated with a mixture (38) comprising at least one oxido-reduction enzyme specific to said component and at least one mediator transfering the electrons between said enzyme et said current collector, characterized in that the mediator is selected amongst the complexes of a transition metal with at least one bipyridine, terpyridine or phenanthroline ligand substituted by at least one electron donor group. Said sensor is applicable more particularly to the detection of glucose.
Multiuser precoders for fixed receivers (2004)

We consider the problem of designing precoders for multiuser systems using fixed receivers. We first derive a precoder that minimizes the transmitted power subject to signal to interference plus noise ratio (SINR) constraints, and then derive a precoder that maximizes the worst case SINR subject to a power constraint. We show that both problems can be solved using standard optimization packages. In contrast to most of the existing precoders, our precoder design is not limited to full rank systems, and is applicable to systems in which the number of users is smaller, equal or larger than the processing gain. Simulation results in a multiuser system show that the proposed precoders can significantly outperform existing linear precoders.
Magnonic band structure in a Co/Pd stripe domain system investigated by Brillouin light scattering and micromagnetic simulations (2017)

By combining Brillouin light scattering and micromagnetic simulations, we studied the spin-wave (SW) dynamics of a Co/Pd thin film multilayer, which features a stripe domain structure at remanence. The periodic up and down domains are separated by corkscrew type domain walls. The existence of these domains causes a scattering of the otherwise bulk and surface SW modes, which form mode families, similar to a one-dimensional magnonic crystal. The dispersion relation and mode profiles of SWs are measured for the transferred wave vector parallel and perpendicular to the domain axis.
Influence of Mechanics on Tendon and Muscle Development (2000)

Tendons are essentially parallel fibers of collagen, ~70 % of the dry weight, interspersed with fibroblasts that are responsible for the development and maintenance of tendon physiology. Tissue engineering of collagen structures involves the interaction of cellular and collagen mechanics and growth, providing a challenge to tendon development models. Our attempts to elucidate these interactions are based on the alignment of collagen either by physiological or mechanical means. Tendon fibroblasts in culture attempt to align isotropic collagen gels, constrained only by cross-links, and when grown alone will spontaneously form macroscopic tendon-like structures that are under cell-mediated tension.1, 2 We are currently reproducing these results with fibroblasts obtained from rat Achilles tendon to generate aligned collagenous structures. Aligned collagen gels may also be formed by creating a double network.3 The collagen network is allowed to partially crosslink under an imposed deformation, it is then placed under additional deformation during further crosslinking. The overall goal in creating these tendon structures is to combine them with self-assembling 3-dimensional muscle constructs, termed myooids, that have already been created in our lab.4 These myooids generate force spontaneously and upon the application of an electrical stimulus. Unfortunately, this force is on the scale of developing muscle, a result of a physiology that resembles muscles of embryonic and neonatal mammals. It is well known that mechanical stimuli are an important factor in muscle and tendon development. The anchors currently used with the myooid do not form a strong interface with the muscle and do not allow for the application of cyclic mechanical strength of physiological intensity. The most suitable anchor for muscle is tendon. We will next explore the bioengineering of myotendonous junctions along with a quantitative description of their mechanical function.
Wavelength multiplexing for FD-OCT speckle averaging (2012)

Quantitative analysis of OCT data can be strongly hampered by speckle. We propose a new method to reduce speckle, operating on a single Fourier-domain optical coherence tomography (FD-OCT) A-line. The full acquired spectrum is used for image generation, exhibiting fully developed speckle. By subdividing the same acquired spectrum in a number of distinct narrower windows, each with a different center frequency, several independent speckles can be generated. These can be averaged to yield a lower-resolution image with strongly reduced speckle. The full resolution image remains available for human interpretation; the low resolution version can be used for parametric imaging. We demonstrate this technique using in vivo intravascular optical frequency domain imaging (OFDI) data.
Expression and functional role of CRIPTO-1 in cutaneous melanoma (2011)

These data indicate that a significant fraction of cutaneous melanoma expresses CR-1 and that this growth factor is involved in the invasion and proliferation of melanoma cells.
Herzerkrankungen in der Schwangerschaft (2016)

Cardiovascular diseases are among the most frequent complications in pregnancies. Among them preexisting heart diseases including congenital heart disease, genetic cardiomyopathies, myocardial infarction and chemotherapy-induced cardiomyopathies display a special challenge for the mother and her physicians. Moreover, the incidence of cardiovascular disease induced by or associated with pregnancy, i.e. hypertensive disorders and peripartum cardiomyopathies, has increased over the past decades. In the present overview we explain why pregnancy is a stress model for the maternal heart and summarize the current knowledge on the influence of pregnancy on preexisting cardiomyopathies. We highlight recent advances in research with regard to hypertensive complications in pregnancy and peripartum cardiomyopathy (PPCM). Moreover, we summarize etiologies, risk factors, pathomechanisms, diagnosis, treatment, management and prognosis. Finally, interdisciplinarity between different clinical fields and basic science is a key requirement to avoid longterm damage to the cardiovascular system induced by pregnancy associated impacts and with this improve women's health in general.
Delay Division Multiplexing DFT Spread FDMA PON by Sub-Nyquist Sampling Rate Receiver (2016)

We propose time delay division DFT-S FDMA PON scheme. Each ONU can receive data by using ADCs of 1/2~1/32 Nyquist Sample Rate such that DFT and IDFT are unnecessary for de-mapping and picking out signals.
Increased Endothelial Expression of Human Soluble Epoxide Hydrolase Negatively Modulates Coronary Reactive Hyperemia in Isolated Mouse Heart (2015)

Coronary reactive hyperemia (RH) is impaired in hypertrophic hearts. Epoxyeicosatrienoic acids (EETs) exert cardioprotective effects in ischemia / reperfusion injury. Soluble epoxide hydrolase (sEH) is the main enzyme responsible for EETs breakdown. EETs level is decreased in transgenic mice with increased endothelial expression of sEH (Tie 2‐sEH tr). We hypothesized that the isolated mouse heart with increased expression of sEH (Tie2‐sEH Tr) exhibits decreased RH through increased hydrolysis of EETs in response to no‐flow ischemia compared to wild type (WT). Coronary flow (CF) in isolated Tie2‐sEH Tr and WT mouse heart was measured using Langendorff system. Perfused isolated heart was exposed to 15 second ischemia and RH was assessed. Following ischemia, flow repayment volume (RV) (the area under the curve and normalized to heart weight (ml/g)) was significantly decreased in Tie2‐sEH Tr compared to WT(8.7 ± 0.8 in Tie2‐sEH Tr vs. 10.7 ± 0.7 in WT, p&lt;0.05). Moreover, Tie2‐sEH Tr exhibited significantly shorter repayment duration when compared to WT (2.4 ± 0.2 in Tie2‐sEH Tr vs. 3.3 ± 0.4 in WT, p&lt;0.05). At the same time, left ventricular developing pressure (LVDP) and heart rate (HR) were not significantly different between the two groups (LVDP was 168.0 ± 15.1 in Tie2‐sEH Tr vs. 133.1 ± 11.6 in WT, p&gt;0.05; HR was 397.7 ± 24.5 in Tie2‐sEH Tr vs. 387.0 ± 14.1 in WT, p&gt;0.05) Our results demonstrate that increased endothelial expression of sEH (Tie2‐sEH Tr) decreases RH compared to WT. These data suggest that increased level of sEH could have a deleterious effect on myocardial recovery from ischemia. Supported by HL‐114559 to MAN and z01‐ES025034 to DCZ
Free Electron Qubits (2019)

We show that a single relativistic free electron can carry one or multiple qubits within its wave-function in Floquet-dressed basis and implement 1-qubit gates based on the electron interaction with designed optical pulses. © 2019 The Author(s)
Data from Oncolysis of Prostate Cancers Induced by Vesicular Stomatitis Virus in PTEN Knockout Mice (2023)

&lt;div&gt;Abstract&lt;p&gt;Vesicular stomatitis virus (VSV) is an oncolytic virus which selectively infects and kills cancer cells. The goal of the present study was to determine the safety and efficacy of VSV treatment of prostate tumors that arise &lt;i&gt;in situ&lt;/i&gt; in immunocompetent, transgenic prostate-specific PTEN-null (PTEN&lt;sup&gt;−/−&lt;/sup&gt;) mice. Interferon-sensitive VSV(AV3 strain), which expresses luciferase, was injected intraprostatically into tumor-bearing PTEN&lt;sup&gt;−/−&lt;/sup&gt; and control mice and then monitored for tissue bioluminescence over 96 hours. Virus readily dispersed throughout the bodies of mice after only 3 hours; however, it persisted at high levels for &gt;72 hours in PTEN&lt;sup&gt;−/−&lt;/sup&gt; mice, but at relatively low levels and for only ∼48 hours in controls. Plaque assays provided a similar pattern, with much higher concentrations of replicating virus in prostates of PTEN&lt;sup&gt;−/−&lt;/sup&gt; mice than in controls. Transient, low levels of virus were detected in the spleens of both groups. Apoptotic analyses by terminal deoxynucleotidyl transferase–mediated dUTP nick end labeling staining revealed that VSV(AV3) is able to selectively infect and kill prostate cells in PTEN&lt;sup&gt;−/−&lt;/sup&gt; mice, while sparing normal cells in control mice. The primary mechanism for cell kill is apparently apoptotic oncolysis as opposed to neutrophil invasion as has been reported using xenograft models. These results suggest that control of locally advanced human prostate cancer may be achievable through intraprostatic injection and amplification of a safe oncolytic virus, such as VSV(AV3). Cancer Res; 70(4); 1367–76&lt;/p&gt;&lt;/div&gt;