gebhart/patrepeval huggingface dataset:
Energy-Efficient Deployment in Wireless Edge Caching (2020)

Edge-caching has received much attention as an efficient technique to reduce delivery latency and network congestion during peak-traffic times by bringing data closer to end users. Existing works usually design caching algorithms separately from physical layer design. In this chapter, we analyze edge-caching wireless networks by taking into account the caching capability when designing the signal transmission. Particularly, we investigate multi-layer caching, where both base station (BS) and users are capable of storing content data in their local cache and analyze the performance of edge-caching wireless networks under two notable uncoded and coded caching strategies. We first calculate backhaul and access throughputs of the two caching strategies for arbitrary values of cache size. The required backhaul and access throughputs are derived as a function of the BS and user cache sizes. Then closed-form expressions for the system energy efficiency (EE) corresponding to the two caching methods are derived. Based on the derived formulas, the system EE is maximized via a precoding vectors design and optimization while satisfying a predefined user request rate. Two optimization problems are proposed to minimize the content delivery time for the two caching strategies.
1:2 Trimethylphosphine Complexes of the Group IV Tetrahalides, trans-MX4•2P(CH3)3 and trans-MX4•2P(CD3)3 (where M = Si, Ge, or Sn; X = Cl or Br); Assignment of Metal–Phosphorus modes (1973)

The vibrational spectra of some 1:2 trimethylphosphine adducts of the group IV tetrahalides, which contain ligands in a trans configuration, are examined in detail using perdeutero-trimethylphosphine to facilitate the assignment of all metal–halogen and metal–phosphorus stretching modes. Preparation of SiCl 4• 2PMe 3 with a 1:1 mixture of P(CH 3 ) 3 and P(CD 3 ) 3 enables an almost unambiguous assignment of the spectrum of this adduct. Normal coordinate calculations for all adducts are reported.
Blue diode-pumped solid-state-laser based on ytterbium doped laser crystals operating on the resonance zero-phonon transition (2023)

The invention provides an efficient, compact means of generating blue laser light at a wavelength near .about.493+/-3 nm, based on the use of a laser diode-pumped Yb-doped laser crystal emitting on its zero phonon line (ZPL) resonance transition at a wavelength near .about.986+/-6 nm, whose fundamental infrared output radiation is harmonically doubled into the blue spectral region. The invention is applied to the excitation of biofluorescent dyes (in the .about.490-496 nm spectral region) utilized in flow cytometry, immunoassay, DNA sequencing, and other biofluorescence instruments. The preferred host crystals have strong ZPL fluorecence (laser) transitions lying in the spectral range from .about.980 to .about.992 nm (so that when frequency-doubled, they produce output radiation in the spectral range from 490 to 496 nm). Alternate preferred Yb doped tungstate crystals, such as Yb:KY(WO.sub.4).sub.2, may be configured to lase on the resonant ZPL transition near 981 nm (in lieu of the normal 1025 nm transition). The laser light is then doubled in the blue at 490.5 nm.
Whole Ovary Freezing (2021)

Early detection and aggressive chemotherapy/radiotherapy treatments have improved the long-term survival rates for many young women with various types of cancer. As a consequence of these cytotoxic treatments, their reproductive future can be either short lived or eradicated. For young single women with cancer, oocyte cryopreservation offers the best potential option for achieving a future pregnancy using their own gametes. Unfortunately, the urgent need to commence cytotoxic treatment often does not permit adequate time for cryopreservation of mature oocytes. Conversely, cryopreservation of ovarian tissue eliminates the delay necessary to obtain mature oocytes, but the subsequent potential for establishing pregnancy is currently unknown. Although ovarian tissue cryopreservation is an attractive alternative and frequently used for patients with these conditions, little has been published on the efficacy of various protocols. Cryopreservation of ovarian tissue is more complex than that of gametes or embryos, requiring preservation of multiple cell types, which may vary in volume and water permeability.
Supplementary Methods from Genetic Variants Implicate Dual Oxidase-2 in Familial and Sporadic Nonmedullary Thyroid Cancer (2023)

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Abstract 4497: NVP-BKM120, a novel inhibitor of phosphoinosotide 3-kinase in Phase I/II clinical trials, shows significant antitumor activity in xenograft and primary tumor models (2010)

Abstract A substantial number of epidemiological and experimental studies support an important role for PI3K in the biology of human cancer. The activation of PI3K, and its downstream effectors, has been clearly validated as an essential step for the initiation and maintenance of the tumorigenic phenotype. Parallel to the clinical development of our dual pan-PI3K/mTOR modulators (e.g., NVP-BEZ235), we continued our drug discovery activities to identify PI3K inhibitors with distinct biological and pharmacological profiles. Following a structure-based design strategy, we have identified a new clinical candidate, NVP-BKM120. This 2,6-dimorpholino pyrimidine derivative is a potent pan-PI3K (e.g., IC50= 35 nM, p110α) that does not significantly inhibit other protein or lipid kinases (e.g., IC50= 4.6 μM, mTOR). The compound exhibits potent antiproliferative activity against a broad panel of tumour cell lines by specifically blocking the biological function of PI3K signaling components (e.g. IC50 = 93 nM S473P-Akt in Rat1-p110α cells). The activity of this pan-PI3K inhibitor in cellular settings translates well in in vivo models of human cancer. NVP-BKM120 shows good oral bioavailability in preclinical species and demonstrated significant antitumor activity (growth inhibition or regression) at tolerated doses in xenografts of diverse cancer lineage in mice and rat models. Consistent with its mechanism of action, transient increases in plasma insulin and glucose levels are observed in these studies. Analyses of tumor tissues after acute dosing or at the end of efficacy studies showed a good correlation between compound exposure, PI3K pathway blockade (reduction in P-Akt levels) and antitumor activity. Dose dependent tumor growth delay or regression is also observed in primary tumor models, and, as demonstrated previously with our dual pan-PI3K/mTOR inhibitor NVP-BEZ235, in vivo synergistic activity is observed when NVP-BKM120 is combined with a MEK inhibitor in K-Ras human cancer models. NVP-BKM120 is currently undergoing Phase I/II human clinical trials for the treatment of solid tumors and hematological malignancies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4497.
Inline phase-change switch material optimizations for increased reliability, RF power handling, and integration (2017)

The power handling capabilities of inline phasechange switches (IPCS's) at radio frequencies (RF) has been correlated to the DC threshold voltage (Vth) of the devices. The dependence of Vth on microheater pulsing parameters and device layout has been characterized, accompanied by observation of the size of the amorphous chalcogenide region through scanning transmission electron microscopy (STEM). Use of W-based microheaters in the IPCS processes has improved device performance and reliability, with increases in the product of cutoff-frequency (Fco) and Vth over previous IPCS devices using NiCrSi microheaters. A correlation between the peak allowed RF voltage across the OFF-state switch and the DC Vth of the OFF-device was observed, indicating the DC Vth is an accurate predictor of RF power handling. Inline phase-change switch (IPCS) devices were also fabricated on top of an AlN heat spreading layer deposited on a thick SiO2 layer. The thick SiO2 properly emulates the interlayer dielectric (ILD) thermal properties that prevent direct integration of IPCS devices at the end of a back-end-of-line (BEOL) CMOS process. The AlN acts as a heat spreading layer, enabling the proper thermal quench rate despite the poor low thermal quality conductivity of the oxide underneath such that IPCS devices can be integrated at the end of any microfabrication process - regardless of the substrate or materials underneath. This is attractive for many CMOS applications where wafer real estate is expensive, or in III-V applications where the wafer thermal properties are poor and variable vary among different technologies.
Development of a nanoparticle-based immunotherapy targeting PD-L1 and PLK1 for lung cancer treatment (2022)

Immune checkpoint inhibitors (ICIs) targeting PD-L1 and PD-1 have improved survival in a subset of patients with advanced non-small cell lung cancer (NSCLC). However, only a minority of NSCLC patients respond to ICIs, highlighting the need for superior immunotherapy. Herein, we report on a nanoparticle-based immunotherapy termed ARAC (Antigen Release Agent and Checkpoint Inhibitor) designed to enhance the efficacy of PD-L1 inhibitor. ARAC is a nanoparticle co-delivering PLK1 inhibitor (volasertib) and PD-L1 antibody. PLK1 is a key mitotic kinase that is overexpressed in various cancers including NSCLC and drives cancer growth. Inhibition of PLK1 selectively kills cancer cells and upregulates PD-L1 expression in surviving cancer cells thereby providing opportunity for ARAC targeted delivery in a feedforward manner. ARAC reduces effective doses of volasertib and PD-L1 antibody by 5-fold in a metastatic lung tumor model (LLC-JSP) and the effect is mainly mediated by CD8+ T cells. ARAC also shows efficacy in another lung tumor model (KLN-205), which does not respond to CTLA-4 and PD-1 inhibitor combination. This study highlights a rational combination strategy to augment existing therapies by utilizing our nanoparticle platform that can load multiple cargo types at once.
Structure and Reactivity of an Allylpalladium N-Heterocyclic Carbene Enolate Complex (2004)

A novel anionic N-heterocyclic carbene was prepared and ligated to [Pd(allyl)Cl]2 to yield the complex (NHC-enolate)Pd(allyl). At elevated temperatures in acetonitrile, the allyl ligand undergoes a stereoselective η3−η1−η3 isomerization in an associative process that is first order in CD3CN with ΔH⧧ = 13.5 ± 0.7 kcal mol-1 and ΔS⧧ = −17 ± 2 eu. This complex reacts with electrophiles (HCl, CH3I) at the enolate position.
A novel polymorphism of FcαRI (CD89) associated with aggressive periodontitis (2004)

Immunoglobulin A Fc receptor (FcalphaRI) has been implicated in the pathogenesis of periodontitis, because increased IgA responses and FcalphaRI-bearing neutrophils are observed in the disease lesions. Inter-individual differences in susceptibility to periodontitis may be attributable to genetic variability in FcalphaRI-mediated immunity. We here identified an FcalphaRI novel polymorphism (nt 324 A-to-G transition) in the membrane-distal extracellular domain encompassing the ligand-binding site, not resulting in an amino acid change. We compared the FcalphaRI genotype distributions among 46 Japanese aggressive periodontitis (AGP) patients, 80 race-matched healthy controls (HCs), and 59 Caucasian HCs. No ethnic differences were observed in the FcalphaRI genotype distributions between Japanese and Caucasian HC. Notably, we observed a difference in the genotype distribution between the AGP and HC groups. Carriage rate of the nt 324 A allele was higher in the AGP (65.2%) than that in the HC group (42.5%) (odds ratio 2.54). Polymorphonuclear neutrophils from peripheral blood and gingival crevicular fluid exhibited a decreased phagocytosis of periodontopathic bacteria (Porphyromonas gingivalis) in the nt 324 A/A patients as compared with the nt 324 G/G patients. These results document a genetic polymorphism at the FcalphaRI ligand-binding site to be associated with susceptibility to AGP.
Power Cycling Results of Discrete Gallium Nitride Gate Injection Transistors (2021)

The reliability of discrete GaN Gate Injection Transistors (GIT) in power cycling tests (PCT) was evaluated. The investigation in this paper reveal that discrete GaN GITs achieved several times the lifetime expected by discrete power device lifetime model for Si IGBTs [1]. The large number of Au nailhead bonds, which are placed at the edge of the chip, combined with a strong lateral temperature gradient on chip level can explain this. The power cycling was also a long-time stress of the gate with DC gate current in combination with a cycling drain current. No significant change in parameters was found.
Solar fuels generation and molecular systems: is it homogeneous or heterogeneous catalysis? (2012)

Catalysis is a key enabling technology for solar fuel generation. A number of catalytic systems, either molecular/homogeneous or solid/heterogeneous, have been developed during the last few decades for both the reductive and oxidative multi-electron reactions required for fuel production from water or CO(2) as renewable raw materials. While allowing for a fine tuning of the catalytic properties through ligand design, molecular approaches are frequently criticized because of the inherent fragility of the resulting catalysts, when exposed to extreme redox potentials. In a number of cases, it has been clearly established that the true catalytic species is heterogeneous in nature, arising from the transformation of the initial molecular species, which should rather be considered as a pre-catalyst. Whether such a situation is general or not is a matter of debate in the community. In this review, covering water oxidation and reduction catalysts, involving noble and non-noble metal ions, we limit our discussion to the cases in which this issue has been directly and properly addressed as well as those requiring more confirmation. The methodologies proposed for discriminating homogeneous and heterogeneous catalysis are inspired in part by those previously discussed by Finke in the case of homogeneous hydrogenation reaction in organometallic chemistry [J. A. Widegren and R. G. Finke, J. Mol. Catal. A, 2003, 198, 317-341].
Thymic microenvironment induces HIV expression:physiologic secretion of IL-6 by thymic epithelial cells up-regulates virus expression in chronically infected cells (1992)

The hallmark of infection with HIV-1 is progressive depletion and qualitative dysfunction of the CD4+ Th cell population in infected individuals. Clinical trials of antiretroviral agents have shown that, despite suppression of virus replication, regeneration of the T cell pool does not occur. One proposed explanation for the defective regenerative capacity of the CD4+ T cell pool is infection of early T lymphocyte progenitors or stem cells. An additional explanation could be failure of cells of the intrathymic microenvironment (thymic epithelial (TE) cells) to carry out critical nurturing functions for developing thymocytes, i.e., secretion of thymocyte-trophic cytokines and expression of adhesion molecules. This study examines the effect of HIV on cultured TE cells and determines the role of TE cells in the regulation of viral expression in chronically HIV-infected cells. We found no evidence of infection of TE cells after exposure to HIV-1. However, normal human serum induced secretion of IL-6 by TE cells; induction of TE IL-6 was partially blocked by anti-IFN-gamma antibodies. Moreover, supernatants from TE cells maintained in normal human serum up-regulated HIV replication in chronically HIV-1-infected cells. Because intrathymic T cell precursors can be infected with HIV and T cell precursors come into close contact with TE cells in the thymus, IL-6 secreted by TE cells during normal intrathymic development may induce HIV expression in infected thymocytes in vivo and promote the intrathymic spread of HIV.
Light Microscopy Module (LMM)-Emulator (2016)

The Light Microscopy Module (LMM) is a microscope facility developed at Glenn Research Center (GRC) that provides researchers with powerful imaging capability onboard the International Space Station (ISS). LMM has the ability to have its hardware recongured on-orbit to accommodate a wide variety of investigations, with the capability of remotely acquiring and downloading digital images across multiple levels of magnication.
Effects ofcycloSal-D4TMP Derivatives in H9 Cells with Induced AZT Resistance Phenotype (1999)

Cytotoxic and antiretroviral activity of cycloSal-d4TMP derivatives were tested in a new AZT-resistant H9 cell subline (H9rAZT250). The results showed, that cycloSal-d4TMP derivatives overcame resistance of HIV-1 to d4T in H9rAZT250 cells, which exert decreased thymidine kinase (TK) gene expression.
Language models for keyword search over data graphs (2012)

In keyword search over data graphs, an answer is a non-redundant subtree that includes the given keywords. This paper focuses on improving the effectiveness of that type of search. A novel approach that combines language models with structural relevance is described. The proposed approach consists of three steps. First, language models are used to assign dynamic, query-dependent weights to the graph. Those weights complement static weights that are pre-assigned to the graph. Second, an existing algorithm returns candidate answers based on their weights. Third, the candidate answers are re-ranked by creating a language model for each one. The effectiveness of the proposed approach is verified on a benchmark of three datasets: IMDB, Wikipedia and Mondial. The proposed approach outperforms all existing systems on the three datasets, which is a testament to its robustness. It is also shown that the effectiveness can be further improved by augmenting keyword queries with very basic knowledge about the structure.
Gallbladder Ejection Fraction (1994)

Thirty consecutive patients with intact gallbladders and biliary pain were evaluated to determine whether gallbladder ejection fraction could identify sphincter of Oddi dysfunction. The mean gallbladder ejection fraction was 45% in patients with abdominal pain and 72% in normal controls. Gallbladder ejection fractions were then correlated with endoscopically measured sphincter of Oddi pressures in patients with abdominal pain. The mean gallbladder ejection fraction was 41% in 7 patients with elevated sphincter pressures and 46% in 23 patients with normal pressures (P = NS). Thirty-six percent of patients with elevated pressures and 33% of patients with normal pressures had abnormal gallbladder ejection fractions. Gallbladder ejection fraction had a sensitivity of 33%, a specificity of 63%, and a positive predictive value of 25% for detection of elevated pressures. Regression analysis revealed a poor correlation between sphincter pressure and gallbladder ejection fraction (r2 = 0.02). These findings suggest that gallbladder ejection fraction cannot be used to diagnose sphincter of Oddi dysfunction in patients before they undergo cholecystectomy.
Parametric study of wearable antennas with varying distances from the body and different on-body positions (2007)

The concept of being connected anywhere and everywhere and also the constant monitoring of human health and behaviour in various environments are the main drivers for developing and researching potential wireless sensor network applications. The paper presents the investigation and analysis performed to highlight the main characteristics of body-worn antennas and on-body communication. Antennas studied included planar conventional dipole and monopoles and modified and miniaturised printed structures. Numerical modelling techniques were applied as the main investigation method enabling efficient and convenient means of extracting and analysing the desired results and data. Effect of different body locations on the wearable antenna performance is highlighted by means of experimental investigations, in addition to on-body propagation measurement which resulted in path loss values in good agreement with simulation.
Age-related evolutions of the dermis: Clinical signs, fibroblast and extracellular matrix dynamics (2018)

Ageing is today a major societal concern that is intrinsically associated with the increase of life expectancy. Outside the context of severe degenerative diseases that affect the elderly populations, normal visible signs of ageing, notably skin sagging and wrinkles, influence the social and individual perception of peoples. Accordingly, there is a strong demand for researches on skin ageing. Deciphering the cellular and molecular processes of skin evolution through ageing is thus an active scientific domain, at the frontier of tissue developmental and ageing biology. The focus of the present article is to provide an overview of the current knowledge concerning the evolution of dermis characteristics at different life stages, from intra-uterine to post-natal life. The description will integrate stage-specific and age-related changes in dermis characteristics at the tissue, cell, and molecular levels.
Biodegradable Microparticles with an Entrapped Branched Octameric Peptide as a Controlled-Release HIV-1 Vaccine (1997)

Polyactide-co-glycolide microparticles, with an entrapped branched octameric peptide from human immunodeficiency virus (HIV-1), were prepared by a solvent evaporation method. The microparticles were characterized for size distribution, antigen loading level, and integrity. Mice in one group were each immunized with a single dose of a controlled-release microparticle formulation containing 300 micrograms of peptide and the serum IgG responses to the antigen were compared with those of mice from a second group that were immunized at 0, 4, and 26 weeks with 100-microgram doses of the same peptide immunogen adsorbed to alum. The controlled-release microparticles induced an antibody response comparable to that from the alum-immunized group. The subcutaneous and the intramuscular routes of administration were compared in additional groups of mice for the microparticles, and both routes induced similar responses. A suspending vehicle for the microparticles was also evaluated and did not affect the immunogenicity of the controlled-release formulation containing both small and large microparticles, although the immunogenicity of smaller microparticles immunized alone was affected.
The impact of electrode dielectric coating on the insulation integrity of GIS/GITL with metallic particle contaminants (2002)

Coating the inside surface of gas insulated switchgear (GIS) enclosures with a dielectric film reduces the deleterious effect of electrode surface roughness, impedes the development of metallic particle initiated microdischarges, increases the field required to lift particles, and reduces the charge acquired by particles, all of which help alleviate the adverse effect of contaminating metallic particles on insulation withstand. The performance of particle-contaminated compressed gas systems with dielectric coated electrodes is analyzed. Two mechanisms for the transfer of charge from electrodes to contaminating particles are considered, namely, conduction through the coating layer and microdischarges in the surrounding gas. The paper presents an electrostatic study of the particle lifting fields with dielectric covered electrodes. The overall breakdown strength of the system is evaluated and the results are discussed in the light of experimental findings.
Session details: HMDs in Augmented & Virtual Reality (2015)

No abstract available.