gebhart/patrepeval huggingface dataset:
Total Synthesis of Pinnatoxin A (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTotal Synthesis of Pinnatoxin AJohn A. McCauley, Kazuo Nagasawa, Peter A. Lander, Steven G. Mischke, Marcus A. Semones, and Yoshito KishiView Author Information Department of Chemistry and Chemical Biology Harvard University, Cambridge, Massachusetts 02138 Cite this: J. Am. Chem. Soc. 1998, 120, 30, 7647–7648Publication Date (Web):July 15, 1998Publication History Received14 April 1998Published online15 July 1998Published inissue 1 August 1998https://pubs.acs.org/doi/10.1021/ja981257ohttps://doi.org/10.1021/ja981257orapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views2997Altmetric-Citations152LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Aldehydes,Anions,Chemical structure,Cyclization,Ketones Get e-Alerts
Functionalization of SiO2 Nanoparticles and Their Superhydrophobic Surface Coating (2012)

Silica (SiO2) nanoparticles synthesized from the gas phase in a microwave plasma reactor were dispersed in organic solvents and subsequently chemically modified with silane coupling agents (SCAs) to reduce agglomeration. A transparent and stable dispersion of silica nanoparticles in toluene could be achieved after functionalization with octyltriethoxysilane (OTES). FTIR measurements indicated that the concentration of free hydroxyl groups on the nanoparticle surface was notably decreased. Nanodispersions of functionalized silica particles with several SCAs were prepared and coated onto glass substrates. The resulting highly hydrophilic/hydrophobic glass substrates were investigated by water contact angle measurements. As a result, the hydrophobically OTES-functionalized silica nanoparticles in toluene showed an average diameter of 28 nm and remained for more than eight weeks.
ROTATIONAL SPECTRUM, STRUCTURE, AND DIPOLE MOMENT OF THE $SiF_{4}$ $NH_{3}$ SYMMETRIC TOP (1991)

It has been suggested recently that Si-F bonds are highly ionic in $character,^{1}$ and theoretical electron density analysis supports a strongly ionic Si-H bond in, for example, $SiH_{4}$.$^{2}$ Microwave spectroscopy can address to some extent the nature of the Si-F and Si-H bonds. High quality ah initio calculations indicate a strongly bound axial dimer $SiF_{4}-NH_{3}$ with a calculated well depth of 10.5 kcal and a short Si-N bond $distance.^{3}$ We have obtained the rotational spectra of various isotopically substituted $SiF_{4}-NH_{3}$ dimers (as well as of $SiH_{4}-NH_{3}$) and assigned them as symmetric tops with internal rotation present. For the main isotopic species of $SiF_{4}-NH_{3}$ we find $B_{0} = 2502.4777 MHz$. Analysis of the structure indicates that the $F_{ax}-Si-F_{eq}$ angle is about $97^{0}$ differing greatly from the tetrahedral $109.5^{0}$- This change in geometry should give a large dipole moment for the dimer if the Si-F bond dipoles are large, as one would expect for an ionic bond. Ab initio calculations indicate a dimer dipole moment of 4.2 $D,^{4}$ which exceeds the sum of monomer moments by 2.7 D. We plan to report the dipole moment, compare the experimentally derived geometry with the ab initio calculated geometry, and discuss the internal rotation of the $SiF_{4}$ and $NH_{3}$ tops. Spectra were observed with a Balle/Flygare pulsed nozzle, Fourier transform spectrometer. Assignment of the internal rotation states was aided by observing a time profile of the population of the state as the gas pulse evolves, with the internal rotor state populations remarkably dependent on whether the front, middle or end of each gas pulse is probed. This effect will also be discussed.
Direct Catalytic Enantioselective α‐Aminomethylation of Ketones (2004)

A proline-catalyzed Mannich reaction produces α-aminomethylated ketones in high yield and with excellent ee values (see scheme). The Mannich bases resulting from this highly practical one-pot three-component asymmetric reaction are of particular interest, for example, as synthetic building blocks and precursors of pharmaceutically valuable 1,3-amino alcohols.
Idiotypic Games within the Immune Network (1986)

In this paper, we have considered the problem of selection of available repertoires. With Ab2 as immunogens, we have used the idiotypic cascade to explore potential repertoires. Our results suggest that potential idiotypic repertoires are more or less the same within a species or between different species. A given idiotype "à la Oudin" can become a recurrent one within the same outbred species or within different species. Similarly, an intrastrain crossreactive idiotype can be induced in other strains, even though there is a genetic disparity between these strains. The structural basis of this phenomenon has been explored. We next examined results showing the loss and gain of recurrent idiotypes without any intentional idiotypic manipulation. A recurrent idiotype can be lost in a syngeneic transfer and a private one can become recurrent by changing the genetic background. The change of available idiotypic repertoires at the B cell level has profound influences on the idiotypic repertoires of suppressor T cells. All these results imply that idiotypic games are played by the immune system itself, a strong suggestion that the immune system is a functional idiotypic network.
Enhancing EEG Surface Resolution by Using a Combination of Kalman Filter and Interpolation method (2016)

International audience
Characterization of anti-Z-RNA polyclonal antibodies: epitope properties and recognition of Z-DNA (1988)

Chemically brominated poly[r(C-G)] [Br-poly[r(C-G)]] containing 32% br8G and 26% br5C was recently shown to contain a 1:1 mixture of A- and Z-form unmodified nucleotides under physiological conditions of temperature, pH, and ionic strength [Hardin, C. C., Zarling, D. A., Puglisi, J. D., Trulson, M. O., Davis, P. W., & Tinoco, I., Jr. (1987) Biochemistry 26, 5191-5199]. Proton NMR results show that more extensive bromination of poly[r(C-G)] (49% br8G, 43% br5C) produces polynucleotides containing greater than 80% unmodified Z-form nucleotides. Using these polynucleotides as antigens, polyclonal antibodies were elicited in rabbits and mice specific for the Z-form of RNA. IgG fractions were purified from rabbit anti-Br-poly[r(C-G)] sera and characterized by immunoprecipitation, nitrocellulose filter binding, and ELISA. Two different anti-Z-RNA IgG specificities were observed. Decreased levels of brominated nucleotides in the immunogen correlated with an increased extent of specific cross-reactivity with Z-DNA. Inoculation of rabbits with polynucleotide immunogens containing 49% br8G and 43% of br5C produced specific anti-Z-RNA IgGs that do not recognize Z-DNA determinants. This suggests that the 2'-OH group is part of the anti-Z-RNA IgG determinant. In contrast, Br-poly[r(C-G)] immunogens containing 32% br8G and 26% br5C produced IgGs that specifically recognize both Z-RNA and Z-DNA. These results show that the bromine atoms are not required for recognition of the Z conformation by the antibodies. The affinity of these anti-Z-RNA IgGs for Z-RNA is about 10-fold higher than for Z-DNA.(ABSTRACT TRUNCATED AT 250 WORDS)
Hand eye coordination patterns in target selection (2000)

In this paper, we describe the use of eye gaze tracking and trajectory analysis in the testing of the performance of input devices for cursor control in Graphical User Interfaces (GUIs). By closely studying the behavior of test subjects performing pointing tasks, we can gain a more detailed understanding of the device design factors that may influence the overall performance with these devices. Our Results show them are many patterns of hand eye coordination at the computer interface which differ from patterns found in direct hand pointing at physical targets (Byrne, Anderson, Douglass, & Matessa, 1999).
Green Move: Towards next generation sustainable smartphone-based vehicle sharing (2012)

Abstract—This paper presents the Green Move project, which is currently ongoing at Politecnico di Milano. The goal of Green Move is to create an innovative vehicle sharing system, based on electric vehicles, which can easily be accessed by users with little required infrastructure and few intermediaries. The paper provides an overview of the project, briefly describes the architecture of the system under development, and outlines the next steps in this research. I.
Electron mobility and velocity in Al0.45Ga0.55N-channel ultra-wide bandgap HEMTs at high temperatures for RF power applications (2022)

Ultra-wide bandgap AlGaN has attracted recent attention as a promising channel material for next-generation high electron mobility transistors (HEMTs) for RF power due to its high critical field, excellent transport properties, and potential for operation in extreme environments. However, the effects of temperature on the transport properties are not fully understood. Here, Al0.62Ga0.38N/Al0.45Ga0.55N HEMTs have been fabricated and characterized up to 150 °C at DC and RF to evaluate the effect of temperature on electron mobility and carrier velocity. Measured results indicate that both mobility and carrier velocity exhibit modest dependence on temperature, suggesting that AlGaN channel HEMTs are promising for future RF power applications.
Hormonal responses to long-term converting enzyme inhibition in hypertensive patients (1981)

Captopril was given alone and in combination with diuretics to 49 patients with hypertension for 1 to 12 mol Within 2 mo blood pressure reduction correlated with pretreatment plasma renin activity and response to the infusion of angiotensin II antagonist, but these effects were not present at 4 mo. Plasma and urinary aldosterone were suppressed but serum converting enzyme activity, plasma bradykinin, kallikren, and prostaglandins (E and F) were in the normal range effect of captopril. Despite sustained reduction of blood pressure, plasma catecholamines were not elevated and urinary catecholamines were suppressed in patients on captopril alone. It is concluded that another mechanism, such as enhancement of renal or local kinin-prostaglandin system, as well as suppression of the renin-angiotensin-aldosterone system may be involved in the long-term efficacy of captopril. Sympathetic activity may also be depressed and contribute to the hypotensive effect.
Non-monotonic Surface Charging Behavior of Platinum: A Paradigm Change (2016)

In electrochemical systems, metal surface charging phenomena dictate the strength of electrostatic interactions between the electrified electrode and ions in solution. These effects are of vital importance for electrochemical reactions in general. Historically, the potential of zero charge (pzc) of the metal has been employed to parametrize the surface charging relation. The structural model of the electrified interface presented in this article goes beyond the oversimplified pzc concept by accounting for the formation of surface oxide and the orientational ordering of interfacial water molecules. The analytical solution of the model reveals a peculiar non-monotonic charging behavior. The Pt surface exhibits a negative effective charge in a low potential region, a positive charge in an intermediate potential region, and a negative charge in a high potential region due to surface oxide dipoles. This non-monotonic behavior is in agreement with a seminal experimental work of Frumkin and Petrii [Electrochim. Acta 1975, 20, 347−359] that had remained hitherto unexplained.
Prediction of clinically significant weight loss with Gelesis100 in the GLOW study as early as 8 weeks post-treatment (2019)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Programmed cell death protein-1 (PD-1)-expression in the microenvironment of classical Hodgkin lymphoma at relapse during anti-PD-1-treatment (2018)

Programmed cell death protein-1 (PD-1)-expression in the microenvironment of classical Hodgkin lymphoma at relapse
Intrinsic and extrinsic Gilbert damping in exchange-biased IrMn/Cu/CoFe trilayer films (2015)

We studied the intrinsic and extrinsic Gilbert damping constants measured with an all-optical method in an exchange-biased IrMn/Cu/CoFe trilayer system with various Cu-spacer layer thicknesses. To understand the effect of the exchange bias on damping, the strength of the exchange bias was controlled by the Cu-spacer layer. When the external magnetic field is high enough compared with the exchange fields, the intrinsic Gilbert damping constant is independent of the exchange bias field. On the other hand, under a low external magnetic field, the extrinsic Gilbert damping is dominant because of the magnetic inhomogeneities, and is strongly correlated with the exchange bias field.
AMD 400G Adaptive SmartNIC SoC: Technology preview (2022)

Agenda
Charge-exchange photoproduction of thea2−(1320)in association withΔ++at 19.3 GeV/c (1990)

We examine the negative $3\ensuremath{\pi}$ final state produced in association with ${\ensuremath{\Delta}}^{++}(1232)$ in the reaction $\ensuremath{\gamma}p\ensuremath{\rightarrow}{\ensuremath{\Delta}}^{++}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}{\ensuremath{\pi}}^{\ensuremath{-}}$ at an incident photon energy of 19.3 GeV. The most prominent enhancement in the $3\ensuremath{\pi}$ spectrum occurs at a mass and with a width consistent with the parameters of the ${a}_{2}(1320)$. This identification is confirmed by the various angular distributions. The ${a}_{2}$ production cross section, corrected for efficiencies and alternate ${a}_{2}$ decay modes, is 0.45\ifmmode\pm\else\textpm\fi{}0.05 \ensuremath{\mu}b.
Abstract LB-410: A single nucleotide polymorphism in human PIGK gene associates with low PIGK expression in colorectal cancer patients (2010)

Abstract Colorectal cancer (CRC) has one of the highest incidences of cancers worldwide and is the fourth most common cancer among men and women in the United States. In Israel, approximately 3000 new CRC cases are being diagnosed annually, representing 13% of all new cases. CRC ranks second in the total number of cancer cases both in the Jewish male and female population. It is uncommon in the non-Jewish (Arab) population. Phosphatidylinositol glycan, class K (PIGK) is an integral member of the Glycosylphosphatidylinositol transamidase (GPIT) protein complex that attaches a diverse group of macromolecules to the plasma membrane of eukaryotes. It is well established that PIGK catalyzes the endoproteolysis and amidation steps involved in transfer of a GPI-anchor to proteins. However, the role of PIGK in tumorigenesis remains largely unknown. Recently, we found a markedly low expression of PIGK protein in some colorectal cancer (CRC) patients. In order to understand the mechanism behind, we examined all the 10 exons of the PIGK gene by DNA sequencing and genotyping in 20 CRC patients from Israel (16 Jews and 4 Arabs). Corresponding expression of the PIGK protein was also determined by immunohistochemistry in all the above CRC patients. We found a single nucleotide polymorphism (C/C C/G or G/G; rs1048575) in the 3′UTR of the PIGK gene in 65% (13/20) of the CRC patients. Most of the patients with the altered genotype were Jews (12 vs. 1). Three out of four Arab patients (75%) exhibited the ancestral C/C genotype. We also observed a significantly low (P&amp;lt;0.002) expression of PIGK protein in all the patients with the altered allele (C/G or G/G) compared to the ancestral alleles (C/C). Similar observation was made on PIGK expression in a couple of transformed human colon cell lines with the ancestral (C/C) and altered (/C/G) genotype. Our results demonstrate for the first time a link between the SNP-1048575 and low PIGK expression in CRC patients and also suggest a possible association between altered PIGK expression and CRC susceptibility. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-410.
Pseudohypoaldosteronism type 1 due to novel variants of SCNN1B gene (2016)

PHA1 is a rare genetic condition, causing functional abnormalities of the amiloride-sensitive ENaC.PHA1 was caused by previously unreported SCNN1B gene mutations (c.1288delC and c.1466+1 G>A).Early recognition of this condition and adherence to symptomatic therapy is important, as the electrolyte abnormalities found may lead to severe dehydration, cardiac arrhythmias and even death.High doses of sodium polystyrene sulfonate, sodium chloride and sodium bicarbonate are required for symptomatic treatment.
High-speed DBPSK signal generation by low-Vπ modulator using thin LiNbO 3 substrate (2009)

We demonstrated 100-Gb/s DBPSK signal generation by using a thin-LiNbO 3 -substrate modulator. The low Vΰ and the reduction in the propagation loss of electrodes helps realize high-speed PSK operation.
Phase I/II study of the anti-CD19 maytansinoid immunoconjugate SAR3419 administered weekly to patients (pts) with relapsed/refractory B-cell non-Hodgkin lymphoma (NHL). (2011)

8017 Background: SAR3419 (huB4-DM4) is an antibody–drug conjugate composed of a humanized IgG1 monoclonal antibody, huB4, which specifically targets the CD19 antigen, conjugated through a disulfide link to the maytansinoid derivative DM4, a potent tubulin inhibitor. After binding to the CD19 antigen, SAR3419 undergoes internalization and intracellular release of DM4. Methods: In this phase I/II study SAR3419 was administered by intravenous infusion, weekly for 8 to 12 doses, to pts with relapsed/refractory B-cell NHL expressing CD19. Results: Forty-four pts were enrolled at 7 dose levels from 10 to 70 mg/m². Main histologies were follicular (18; 41%) and diffuse large B-cell (17; 39%). Median number of prior regimens was 3 (1-8) and 19 pts had received prior transplantation. Twenty-eight pts were enrolled in the dose escalation part. Of 6 pts at 70 mg/m², 1 pt had a protocol defined dose limiting toxicity of neutropenia and 2 pts had grade 2 significant toxicities with late onset: blurred vision associated with corneal deposits and left bundle branch block. The maximum tolerated dose (MTD) was defined at 55 mg/m². Of 22 pts at the MTD, 4 pts had related reversible grade 3-4 toxicities after 6-8 doses: optic neuropathy, paraesthesia, neutropenia and thrombocytopenia. Of 38 pts at doses of 20 mg/m² or higher, 12 (32%) pts achieved an objective response including 6 CR/CRu, with no obvious dose effect. Of 22 pts at the MTD (55 mg/m²), 8 (36%) had a response, including 3 CR/CRu. Of 9 pts evaluable for response duration (RD), 4 pts had a RD ranging from 6 to at least 12 months. Conclusions: These results demonstrate evidence of clinical activity and manageable safety, without significant myelosuppression. A modified schedule (4 weekly doses of 55 mg/m² followed by every 2 weeks dosing) is under evaluation. Updated clinical and pharmacokinetic data will be presented.
SYNTHESIS OF 1-(2-HYDROXY-3-METHOXYPROPYL)URACILS AND THEIR ACTIVITY AGAINST L1210 AND MACROPHAGE RAW 264.7 CELLS (2002)

The title compounds were obtained from appropriate 5-substituted uracil derivatives and 1,2-oxy-3-methoxypropane in the presence of sodium hydride. Under similar conditions 5-iodouracil gave 2-methoxymethyl-2,3-dihydro-oxazolo[3,2-c]pyrimidine-5,7-dione as a result of intramolecular cine type nucleophilic substitution. Cytotoxicity of 1-(2-hydroxy-3-methoxypropyl)-5-substituted uracil derivatives against L1210 and macrophage RAW 264.7 cells in vitro was examined.
In vitropharmacological characterization of a novel p38α (MAPK14) inhibitor designed for inhaled delivery (2016)

<b>Introduction</b> The p38α (MAPK14) is a kinase which regulates the production of key inflammatory mediators, including TNF-α and IL-8. To date, losmapimod is the most advanced p38α inhibitor currently progressed to clinical trials in COPD in an oral formulation. Inhaled drug delivery may achieve pharmacologically relevant lung concentrations with limited systemic exposure. We report the <i>in vitro</i> characterization of a novel p38α inhibitor specifically designed for inhaled administration. <b>Methods and Results</b> CHI-91040 proved to be &gt;100-fold more potent in inhibiting p38α (IC<sub>50</sub>= 0.14 nM) and p38β (IC<sub>50</sub>= 0.14 nM) enzymatic activity than losmapimod (IC<sub>50</sub> values of 23 and 138 nM, respectively). CHI-91040 showed a &gt;6,000-fold selectivity against p38γ, p38δ as well as against a panel of more than 400 human kinases. By using surface plasmon resonance to measure dissociation enzyme kinetics, the calculated t<sub>1/2</sub> of CHI-91040 was &gt;24h, suggesting a potential long duration of action. In human peripheral blood mononuclear cells, CHI-91040 inhibited (IC<sub>50</sub>=1.0) LPS-stimulated TNF-α release more potently than losmapimod (IC<sub>50</sub>=27 nM). CHI-91040 also inhibited LPS-evoked release of TNF-a from rat alveolar macrophages (IC<sub>50</sub>=3.5 nM), IL-8 release from BEAS-2B airway epithelial cells (IC<sub>50</sub>=1.2 nM) and IL-8 release induced by cigarette smoke extract in bronchial smooth muscle cells (IC<sub>50</sub>=1.1 nM). <b>Conclusions</b> CHI-91040, which is currently undergoing clinical evaluation as a novel treatment for COPD and/or severe asthma, shows a robust anti-inflammatory profile which correlates with its inhibitory potency against p38α.
Short‐term effects of octreotide on blood pressure and plasma catecholamines and neuropeptide Y levels in patients with phaeochromocytoma: a placebo‐controlled trial (1995)

In the present controlled conditions, short-term administration of octreotide had no antisecretory effect in patients with phaeochromocytoma.
Energy efficient spectrum sensing and handoff strategies in cognitive radio networks (2013)

Abstract—The limited spectrum resources and dramatic growth of high data rate communications have motivated oppor-tunistic spectrum access using the promising concept of cognitive radio networks. Although this concept has emerged primarily to enhance spectrum utilization, the importance of energy con-sumption poses new challenges, because energy efficiency and communication performance can be at odds. In this paper, the existing approaches to energy efficiency spectrum sensing and handoff are classified. The tradeoff between energy consumption and throughput is established as function of the numerous design parameters of cognitive radio networks, both in the case of local and of cooperative spectrum sensing. It is argued that a number of important aspects still needs to be researched, such as fairness, dynamic behavior, reactive and proactive schemes for energy efficiency. I.