gebhart/patrepeval huggingface dataset:
AN UNUSUAL PHYCOCYANOBILIN‐CONTAINING PHYCOERYTHRIN OF SEVERAL BLUISH‐COLORED, ACROCHAETIOID, FRESHWATER RED ALGAL SPECIES1 (1997)

ABSTRACT The reproductive biology and phycobiliproteins of four different culture isolates of the freshwater algae Audouinella and‘Chantransia’were investigated.‘Chantransia’sp. (3585/UTEX 2623) and Audouinella macrospora (Wood) Sheath et Burkholder (3394,3395) from California and Minnesota reproduced only by monospores. However, A. macrospora (3603/Necchi 1) reproduced by monosporangia that formed successive generations of the Audouinella phase, and Batrachospermum shoots developed from the basal and erect systems. The major light‐harvesting phycobiliprotein in all of these isolates was a phycocyanobilin‐containing phycoerythrin not previously detected in red algae or cyanobacteria. As in the commonly found R‐ and B‐phycoerythrins, Audouinella phycoerythrin had a native molecular mass of ∼ 240,000 and was made up of α, β, and γ subunits. Audouinella phycoerythrin carried two phycoerythrobilins on the α subunit; one phycourobilin, one phycoerythrobilin, and one phycocyanobilin on the β subunit; and one phycourobilin and two phycoerythrobilins on the γ subunit. With excitation at 495, 563, or 603 nm, the fluorescence emission peak of Audouinella phycoerythrin was at 626 nm, showing that phycocyanobilin was the terminal energy acceptor.
Oral hypofunction and association with need for daily assistance among older adults in long‐term care (2022)

OHF score based on the five signs can be used to determine OHF severity. OHF was common and associated with occlusal status, cognitive impairment and need for assistance in oral hygiene, moving and eating in older adults living in LTC.
Semiconductor-diode array pumped solid-state laser systems: a prospectus (1987)

We review immediate and projected uses of solid-state lasers made possible by efficient and powerful semiconductor-laser-diode arrays as pump sources.
Evidence that Mono-ADP-Ribosylation of CtBP1/BARS Regulates Lipid Storage (2007)

Mono-ADP-ribosylation is emerging as an important posttranslational modification that modulates a variety of cell signaling pathways. Here, we present evidence that mono-ADP-ribosylation of the transcriptional corepressor C terminal binding protein, brefeldin A (BFA)-induced ADP-ribosylated substrate (CtBP1/BARS) regulates neutral lipid storage in droplets that are surrounded by a monolayer of phospholipid and associated proteins. CtBP1/BARS is an NAD-binding protein that becomes ribosylated when cells are exposed to BFA. Both endogenous lipid droplets and droplets enlarged by oleate treatment are lost after 12-h exposure to BFA. Lipid loss requires new protein synthesis, and it is blocked by multiple ribosylation inhibitors, but it is not stimulated by disruption of the Golgi apparatus or the endoplasmic reticulum unfolded protein response. Small interfering RNA knockdown of CtBP1/BARS mimics the effect of BFA, and mouse embryonic fibroblasts derived from embryos that are deficient in CtBP1/BARS seem to be defective in lipid accumulation. We conclude that mono-ADP-ribosylation of CtBP1/BARS inactivates its repressor function, which leads to the activation of genes that regulate neutral lipid storage.
Controlling shear jamming in dense suspensionsviathe particle aspect ratio (2019)

Dense suspensions of particles in a liquid exhibit rich, non-Newtonian behaviors such as shear thickening (ST) and shear jamming (SJ).
Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands (2022)

JAK2 is a non-receptor tyrosine kinase that regulates hematopoiesis through the JAK-STAT pathway. The pseudokinase domain (JH2) is an important regulator of the activity of the kinase domain (JH1). V617F mutation in JH2 has been associated with the pathogenesis of various myeloproliferative neoplasms, but JAK2 JH2 has been poorly explored as a pharmacological target. In light of this, we aimed to develop JAK2 JH2 binders that could selectively target JH2 over JH1 and test their capacity to modulate JAK2 activity in cells. Toward this goal, we optimized a diaminotriazole lead compound into potent, selective, and cell-permeable JH2 binders leveraging computational design, synthesis, binding affinity measurements for the JH1, JH2 WT, and JH2 V617F domains, permeability measurements, crystallography, and cell assays. Optimized diaminotriazoles are capable of inhibiting STAT5 phosphorylation in both WT and V617F JAK2 in cells.
First experimental demonstration of self-synchronous phase locking of an optical array (2006)

A novel, highly accurate, all electronic technique for phase locking arrays of optical fibers is demonstrated. We report the first demonstration of the only electronic phase locking technique that doesn't require a reference beam. The measured phase error is lambda/20. Excellent phase locking has been demonstrated for fiber amplifier arrays.
Quantitative phase microscopy of red blood cells during planar trapping and propulsion (2018)

Red blood cells (RBCs) have the ability to undergo morphological deformations during microcirculation, such as changes in surface area, volume and sphericity. Optical waveguide trapping is suitable for trapping, propelling and deforming large cell populations along the length of the waveguide. Bright field microscopy employed with waveguide trapping does not provide quantitative information about structural changes. Here, we have combined quantitative phase microscopy and waveguide trapping techniques to study changes in RBC morphology during planar trapping and transportation. By using interference microscopy, time-lapsed interferometric images of trapped RBCs were recorded in real-time and subsequently utilized to reconstruct optical phase maps. Quantification of the phase differences before and after trapping enabled study of the mechanical effects during planar trapping. During planar trapping, a decrease in the maximum phase values, an increase in the surface area and a decrease in the volume and sphericity of RBCs were observed. QPM was used to analyze the phase values for two specific regions within RBCs: the annular rim and the central donut. The phase value of the annular rim decreases whereas it increases for the central donut during planar trapping. These changes correspond to a redistribution of cytosol inside the RBC during planar trapping and transportation.
Supplementary Figure S3 from <i>Nedd9</i> Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer (2023)

&lt;p&gt;Inhibition of FAK, SRC, or CAMKK in NSCLC cell lines&lt;/p&gt;
Gynecology : a practical approach (1990)

Gynecology:a practical approch , Gynecology:a practical approch , کتابخانه دانشگاه علوم پزشکی و خدمات بهداشتی درمانی کرمان
Expression of cyclins D1 and E in human colon adenocarcinomas. (1997)

Cyclins D1 and E play critical roles in the progression of cells through the G1 phase of the cell cycle. Amplification and/or overexpression of the cyclin D1 gene and aberrant expression of cyclin E have been described in several forms of human cancer. In the present study, we examined the expression of these two genes by Western, Northern and Southern blot analyses in a series of primary human colon carcinomas of various stages and degrees of differentiation and in paired adjacent normal mucosa samples, and also in a series of human colon carcinoma cell lines. About 50% of the colon carcinomas displayed a two to five fold increase in the expression of cyclin D1 mRNA and protein, when compared with the paired normal mucosa samples. Six out of eight carcinomas examined showed a four to nine fold increase in cyclin E mRNA and about 50% of the carcinomas displayed a two to three fold increase in cyclin E protein. Low molecular weight cyclin E-related proteins were observed in four out of ten carcinomas. These changes in cyclins D1 and E occurred in both early and late stage tumors. Three of the six cell lines examined displayed a high expression of cyclin D1 mRNA and protein. A very high level of cyclin E mRNA expression was seen in HCT116 cells and this was associated with the presence of low molecular weight cyclin E-related proteins. None of the primary colon carcinomas nor the six cell lines examined displayed amplification of either the cyclin D1 or cyclin E genes. Thus, an aberrant expression of both cyclins D1 and E occurs in a significant fraction of human colon carcinomas.
Low-Dose Doxazosin Improved Aortic Stiffness and Endothelial Dysfunction as Measured by Noninvasive Evaluation (2002)

Evaluation of atherosclerosis is important in the treatment of hypertension. To evaluate the preventive effects of a small amount of alpha-blockade, arterial and endothelial dysfunction were measured by noninvasive tests, i.e., pulse wave velocity, acceleration plethysmography and strain-gauge plethysmography, in patients with essential hypertension. Fifteen patients (65+/-3 years old) with essential hypertension (WHO stage I or II) were analyzed in this study. We performed noninvasive evaluations to measure aortic stiffness and endothelial dysfunction, in addition to measuring blood pressure, cholesterol profile, and levels of cells adhesion molecules and nitric oxide before and 6 and 12 months after the start of doxazosin treatment (1.0 mg/day). Blood pressure and heart rate did not significantly change during treatment. The pulse wave velocity index was significantly reduced both at 6 (7.72+/-0.23 m/s; p<0.05) and 12 (7.34+/-0.26 m/s; p<0.05) months after the start of treatment compared to the pretreatment level that at baseline. There was also a significant improvement in b/a after 12 months (-0.46+/-0.04; p<0.05) and in d/a after 6 months (-0.38+/-0.03; p<0.05) and 12 months (-0.39+/-0.03; p=0.05) compared to the pretreatment values. Moreover, reactive hyperemia evaluated by strain-gauge plethysmography after 6 months (1.34+/-0.11; p<0.05) and 12 months (1.49+/-0.16; p<0.05) was significantly improved compared to that before treatment, and NOx was significantly increased after 12 months (89.7+/-15.7 micromol/l; p<0.005). These data suggest that a low dose of doxazosin may play an important role in improving arterial stiffness and endothelial dysfunction without changing cardiac hemodynamics.
System and Circuit Design for an MB-OFDM UWB Frequency Synthesizer (2008)

This paper presents a complete top-down design and experimental results for a fast-hopping 11-band 3-10-GHz frequency synthesizer. The system requirements for a synthesizer in an ultrawideband (UWB) radio are discussed. The synthesizer specifications for 480-Mb/s- and 1-Gb/s-data-rate multiband orthogonal-frequency-division-multiplexing UWB radios using quadrature phase shift keying and 16-quadrature amplitude modulation, respectively, are provided. The circuit-level implementation of this microwave system is described in detail including layout considerations. Fabricated in a 0.25-mum SiGe BiCMOS process and integrated in a receiver, the synthesizer was characterized in a quad-flat-no-leads package while being mounted on an FR-4 substrate. Measurement results and a model-hardware correlation analysis are presented.
A RANDOMIZED CLINICAL TRIAL OF DIRECT ANTERIOR APPROACH AND MINI-POSTERIOR APPROACH TOTAL HIP ARTHROPLASTY: WHICH PROVIDES BETTER EARLY FUNCTIONAL RECOVERY? (2018)

115 patients undergoing primary unilateral THA were randomized to either DAA or MPA. Groups did not differ in mean age, sex, or mean body mass index. Functional results included time to discontinue gait aids, discontinue all narcotics, and independence with various activities of daily living. Activity in study subjects was measured with 5 wearable activity monitoring sensors with tri-axial MEMS accelerometers and validated custom algorithms and conducted over three days at pre-op, 2 weeks, 8 weeks, and one year. SF-12, WOMAC, and HHS scores to one year were also tabulated. Early functional recovery slightly favoured DAA compared to MPA; time to discontinue walker (10 vs. 14.5 days), time to discontinue all gait aids (17.3 vs 23.6 days), ascend stairs with gait aid (5.4 vs. 10.3 days), and to walk 6 blocks (20.5 vs. 26.0 days). There were no other differences in early functional milestones. Activity monitoring at two weeks postoperatively slightly favoured DAA; mean steps per day were 3897 versus MPA 2,235...
Femtosecond plasma mediated laser ablation has advantages over mechanical osteotomy of cranial bone (2012)

We demonstrate accelerated bone healing after femtosecond laser ablation in a calvarial defect model compared to traditional mechanical drilling techniques. Improved rates of early regeneration make plasma-mediated ablation of the craniofacial skeleton advantageous for applications to osteotomy.
Multifunctional N-P-doped carbon dots for regulation of apoptosis and autophagy in B16F10 melanoma cancer cells and in vitro imaging applications (2020)

<b>Rationale:</b> The present study reports the multifunctional anticancer activity against B16F10 melanoma cancer cells and the bioimaging ability of fluorescent nitrogen-phosphorous-doped carbon dots (NPCDs). <b>Methods:</b> The NPCDs were synthesized using a single-step, thermal treatment and were characterized by TEM, XPS, fluorescence and UV-Vis spectroscopy, and FTIR analysis. The anticancer efficacy of NPCDs was confirmed by using cell viability assay, morphological evaluation, fluorescent live-dead cell assay, mitochondrial potential assay, ROS production, RT-PCR, western-blot analysis, siRNA transfection, and cellular bioimaging ability. <b>Results:</b> The NPCDs inhibited the proliferation of B16F10 melanoma cancer cells after 24 h of treatment and induced apoptosis, as confirmed by the presence of fragmented nuclei, reduced mitochondrial membrane potential, and elevated levels of reactive oxygen species. The NPCDs treatment further elevated the levels of pro-apoptotic factors and down-regulated the level of Bcl2 (B-cell lymphoma 2) that weakened the mitochondrial membrane, and activated proteases such as caspases. Treatment with NPCDs also resulted in dose-dependent cell cycle arrest, as indicated by reduced cyclin-dependent kinase (CDK)-2, -4, and -6 protein levels and an enhanced level of p21. More importantly, the NPCDs induced the activation of autophagy by upregulating the protein expression levels of LC3-II and ATG-5 (autophagy-related-5) and by downregulating p62 level, validated by knockdown of ATG-5. Additionally, owing to their excellent luminescence property, these NPCDs were also applicable in cellular bioimaging, as evidenced by the microscopic fluorescence imaging of B16F10 melanoma cells. <b>Conclusion:</b> Based on these findings, we conclude that our newly synthesized NPCDs induced cell cycle arrest, autophagy, and apoptosis in B16F10 melanoma cells and presented good cellular bioimaging capability.
Tailored Light-Matter Interaction through Epsilon-Near-Zero Modes (2015)

We use epsilon-near-zero modes in semiconductor nanolayers to design a system whose spectral properties are controlled by their interaction with multi-dipole resonances. This design flexibility renders our platform attractive for efficient nonlinear composite materials.
Report of the HPC Correctness Summit, January 25-26, 2017, Washington, DC (2017)

Technologies for verification and debugging have made significant strides in the context of general systems software. An investment in such technologies to make them applicable for High Performance Computing (HPC) could lead to substantial improvements in the productivity and sustainability of HPC software development. Such improvements will be essential to fully exploit new exascale computer architectures. Without such investment, there is the possibility of a substantial crisis in our ability to advance the field of HPC, as the complexity of our architectures, algorithms, and applications is moving beyond the ability of our developers. As HPC is of strategic importance to our nation, forming the bedrock of its scientific and technological capabilities, such investment is highly warranted.
IN VIVO DETERMINATION OF CONTACT STRESSES FOR SUBJECTS IMPLANTED WITH A POSTERIOR STABILIZED TKA (2008)

At present, contact stress analyses of TKA involve in vitro experimental testing. The objective of this project was to develop a parametric mathematical model that determines in vivo contact stresses for subjects implanted with a TKA, under in vivo, dynamic conditions. It is hypothesized that the results from this model will be more representative of in vivo conditions, thus leading to more accurate prediction of TKA bearing surface stresses. In vivo kinematics were determined for ten subjects implanted with a posterior stabilized TKA during gait and a deep knee bend under fluoroscopic surveillance. Three-dimensional contact positions, determined between the femoral component and the polyethylene insert, were entered into a complicated mathematical model to determine bearing surface forces. In vivo kinematics and kinetics were entered into a deformation model to predict in vivo contact areas between the medial and lateral condyles and tibial insert. The orientation of the femoral and tibial components, the predicted in vivo contact areas, and vectoral information of soft-tissue derived from MRI images were then entered into a mathematical model that predicted in vivo contact stresses between the femoral component and the tibial insert. This is the first computational model that utilizes fluoroscopy, MRI, deformation characteristics and Kane’s theory of Dynamics to predict in vivo contact stresses. Although previous models have not been validated, this model was validated by comparing the predicted foot/ ground force with the experimentally derived force. This study demonstrates that patellar motion influences forces throughout the lower extremity. The in vivo contact stress values predicted in this initial study were less than the yield strength of polyethylene.
Combining Static and Dynamic Permission Analysis for Android (2013)

on an Android device.A list of the permissions the application is requesting is presented to the user, and the user must choose either to install, accepting those permissions, or cancel, declining those permissions.However, it is not necessarily transparent to the user whether an application actually needs all of the permissions (system resources) that it requests.Underprivilege -If an application is not requesting enough permissions, then those features that require those missing permissions will not function properly and the application will generate an error which may cause the application to crash.
PROTECTING PARKING STRUCTURES FROM WATER AND CHEMICAL DAMAGE (1991)

Article discusses methods for protection of parking structures from water and chemical damage. Topics elaborated upon include the following: traffic type and volume; age of structure; climatic conditions; choosing a contractor; selecting a protective system; and common protective systems (water repellant sealers, waterproofing membranes).
The force acting on a superparamagnetic bead due to an applied magnetic field (2007)

This paper describes a model of the motion of superparamagnetic beads in a microfluidic channel under the influence of a weak magnetic field produced by an electric current passing through a coplanar metal wire. The model based on the conventional expression for the magnetic force experienced by a superparamagnetic bead (suspended in a biologically relevant medium) and the parameters provided by the manufacturer failed to match the experimental data. To fit the data to the model, it was necessary to modify the conventional expression for the force to account for the non-zero initial magnetization of the beads, and to use the initial magnetization and the magnetic susceptibility of the beads as adjustable parameters. The best-fit value of susceptibility deviated significantly from the value provided by the manufacturer, but was in good agreement with the value computed using the magnetization curves measured independently for the beads from the same vial as those used in the experiment. The results of this study will be useful to researchers who need an accurate prediction of the behavior of superparamagnetic beads in aqueous suspensions under the influence of weak magnetic fields. The derivation of the force on a magnetic bead due to a magnetic field also identifies the correct treatment to use for this interaction, and resolves discrepancies present throughout the literature.
A Short Introduction to WinBUGS (2004)

1 Why Bayesian analysis using MCMC is good for you 1. Has a very solid decision-theoretical framework 2. It is intuitive: a. Combines the prior distribution (prior beliefs and/or experience) with the likelihood (experiment) to obtain the posterior distribution (accumulated information). b. In this context knowledge is equivalent to distribution and knowledge precision can be quantified by the precision parameter. 3. It is exact. Asymptotic approximations are not used. The “plug–in” principle is avoided. 4. Newly developed numerical methods (MCMC) make computations tractable for practically all models. 5. Focus shifts from model estimation to model correctness. 6. WinBUGS
Optimum Channel Selection of Dual Radar for Respiration Detection - A Time Domain Approach (2019)

Doppler radars can detect respiration rate of a human being without compromising the safety and privacy of the person. The small angle approximation techniques of phase demodulation of continuous wave (CW) Doppler radar for detecting very minute respiratory-chest wall movements suffer from inherent optimum-null point problem. This in turn hinders accurate respiration rate (BR) computations. In this work, we present a novel time domain approach of extracting BR from a dual CW radar (10.525 GHz) setup, by automated selection of optimum channel. The proposed system efficiently computes BR with an mean accuracy of 98.53 ± 0.9%.
Novel PIFA with polarization and frequency agility (2007)

A compact PIFA with polarization and frequency agility was presented. It was shown that using groups of pin diodes the polarization can be switched between two orthogonal linear polarizations. This antenna is devoted to RF front-end of wireless systems using polarization diversity at the reception. Switching between two frequencies can also be achieved. The antenna presented can cover the entire 2.4 GHz ISM band or can be used for WiMax applications at 3.5 GHz.
Functional gut disorders and health care seeking behavior in an Italian non-patient population. (1989)

We conducted a survey on functional gut disorders and health care seeking behavior in a large non-patient population of an Italian region (Umbria). 533 subjects were interviewed by means of a specific questionnaire. 44 (8.5%) reported symptoms compatible with the irritable bowel syndrome, 30 (5.8%) had non-colonic pain, 48 (9.2%) chronic constipation, and 20 (3.8%) dyspepsia. It is concluded that in our region there is a relatively high percentage of subjects that do not commonly seek health care, although affected by functional gut disorders.
Behavioral model of a 1.8 V 6b CMOS flash ADC based on device parameters (2002)

A hierarchical behavioral model of a submicron 6 bit CMOS flash analog to digital converter is presented. Circuit parameters are extracted from process dependent device data using an extension of the g/sub m//I/sub D/ methodology for use in the behavioral model. In using this approach, the model will track changes in physical device geometries without the need for re-characterization. The comparator model is validated against SPICE and system level simulation results are presented for the full converter.