gebhart/patrepeval huggingface dataset:
Type 2 Diabetes Prevention Focused on Normalization of Glycemia: A Two-Year Pilot Study (2021)

The purpose of this study is to assess the effects of an alternative approach to type 2 diabetes prevention. Ninety-six patients with prediabetes (age 52 (10) years; 80% female; BMI 39.2 (7.1) kg/m<sup>2</sup>) received a continuous remote care intervention focused on reducing hyperglycemia through carbohydrate restricted nutrition therapy for two years in a single arm, prospective, longitudinal pilot study. Two-year retention was 75% (72 of 96 participants). Fifty-one percent of participants (49 of 96) met carbohydrate restriction goals as assessed by blood beta-hydroxybutyrate concentrations for more than one-third of reported measurements. Estimated cumulative incidence of normoglycemia (HbA1c <5.7% without medication) and type 2 diabetes (HbA1c ≥6.5% or <6.5% with medication other than metformin) at two years were 52.3% and 3%, respectively. Prevalence of metabolic syndrome, class II or greater obesity, and suspected hepatic steatosis significantly decreased at two years. These results demonstrate the potential utility of an alternate approach to type 2 diabetes prevention, carbohydrate restricted nutrition therapy delivered through a continuous remote care model, for normalization of glycemia and improvement in related comorbidities.
Complications Associated with the Use of Vacuum Constriction Devices for Erectile Dysfunction in the Spinal Cord Injured Population (1994)

The vacuum constriction device has generally been regarded as a safe and effective alternative to pharmacologic intracorporal injections or surgical placement of a penile prosthesis for the treatment of erectile dysfunction. This paper serves to exemplify the potential complications of the device when used to treat erectile dysfunction in the spinal cord-injured (SCI) population.Two cases of subcutaneous penile hemorrhage in patients using anticoagulant therapy (one treated with subcutaneous heparin and one with coumadin) and one case of penile gangrene occurred in three different SCI males. Physicians managing erectile dysfunction in SCI patients should be aware of these potential serious morbidities. The management and means of prevention of these complications are presented. (J Am Paraplegia Soc; 17: 136–139)
Cigarette Smoke, Inflammation, and Lung Injury: A Mechanistic Perspective (2009)

Inflammation is a common feature in the pathogenesis of cigarette smoke-associated diseases. The recruitment of inflammatory cells into the lung following cigarette smoke exposure presents a risk of tissue damage through the release of toxic mediators, including proteolytic enzymes and reactive oxygen species. This review represents a toxicological approach to investigation of cigarette smoke-induced lung injury, with a focus on laboratory studies and an emphasis on inflammatory mechanisms. The studies discussed in this review analyze the role of inflammation and inflammatory mediators in the development of injury. In cases where information relating to cigarette smoke is limited, examples are taken from other models of lung injury applicable to cigarette smoke. The primary aim of the review is to summarize published work so as to permit (1) an evaluation of chronic lung injury and inflammatory responses in animal models, (2) a discussion of inflammatory mediators in the development of chronic injury, and (3) identification of immunological mechanisms of injury. These studies discuss the currently understood roles of cytokines, cell adhesion molecules, and oxidative stress in inflammatory reactions and lung injury. A role for lipocortin 1 (annexin 1), a naturally occurring defense factor against inflammation, is discussed because of the possibility that impaired synthesis and degradation of lipocortin 1 will influence immune responses in animals exposed to cigarette smoke either by augmenting T helper cell Th1 response or by shifting Th1 to Th2 response. While Th1 augmentation will increase the risk for development of emphysema, Th1 to Th2 shift will favor development of asthma.
“S-shaped” Photoluminescence Emission Shift in Cu(In,Ga)Se2 Thin Films (2012)

We have utilized photoluminescence (PL) measurement to investigate carrier recombination mechanism in Cu(In,Ga)Se2 thin films and observed an S-shaped emission shift revealed from the corresponding PL peak of near band edge transition.
Comparative experimental study of junctionless and inversion mode nanowire transistors for analog applications (2020)

International audience
The role of conserved aspartate and serine residues in ligand binding and in function of the 5‐HT1A receptor: A site‐directed mutation study (1992)

Wild-type and mutant serotonin 1A receptors were transiently expressed in COS-7 cells using the infection-transfection variant of the vaccinia virus/T7 polymerase vector system. The amino acid substitutions in the transmembrane regions, Asp82-->Asn82, Asp116-->Asn116, and Ser198-->Ala198 all resulted in a decrease in affinity for 5-HT by 60-100-fold, without affecting the affinity for the antagonist, pindolol. The binding of agonist to the additional mutant, Thr199-->Ala199, was too weak to be measured, 5-HT induced GTPase activities for all receptors studied. These findings indicate that the residues mutated play an important role in the binding of the agonist and less critical roles in the binding of the antagonist pindolol.
Sliding-mode Control of a Twin-body System with 2-relative-RDOF to Achieve Desired Landing Postures (2007)

This study is dedicated to accomplish landing posture control of a twin-body system with 2-relative rotation degree of freedom (RDOF) using method of sliding control. The twin-body system is simplified model of a cellular phone with two relative RDOF, the inclination between two bodies and rotation through self-axis. The objective of the research is controlling the landing posture without structural damage. First, the equations governing the dynamics of the twin-body system are established based on the Lagrange-Euler formulation. The damping uncertainty caused by the actuators with bearing would be considered, and the robust controller is designed based on the sliding control and applied to achieve the control object. Finally, the controller performance is validated by MATLAB simulations. The results show that the designed controller is capable of performing lading control, and the relations between dynamics responses and control variables are discussed.
Variation in performance of candidate surgical quality measures for muscle‐invasive bladder cancer by hospital type (2014)

Patients undergoing RC at AHV hospitals were more likely to meet quality criteria. However, performance remains low across hospital types, highlighting the opportunity to improve quality of care for MIBC.
Hepatitis G virus does not cause significant liver disease after liver transplantation (1998)

The aim of this study was to determine the prevalence of infection with the newly described hepatitis G virus (HGV) in a liver transplant cohort, and to establish the frequency and nature of hepatitis in those with and without HGV infection. A reverse transcriptase-polymerase chain reaction technique was employed to determine viraemia in the patients, and liver biopsies taken at different times after transplantation were assessed histologically. Hepatitis G virus RNA was detected in 47% of the liver transplant recipients investigated. Those positive for HGV had received significantly more blood or blood products than the HGV-negative patients. The frequency of abnormal liver function tests was similar in HGV-positive and HGV-negative recipients. Bile duct epithelial cell damage was more frequently seen in those with HGV viraemia. This study indicates that almost half of the liver transplant recipients in Northern England are positive for HGV, and that infection is associated with exposure to blood and blood products. It appears that, in the immunosuppressed patient, HGV does not cause clinically significant liver disease, at least up to 2 years after transplantation. If HGV infection is associated with hepatitis outside this clinical setting, it is likely that the liver damage is immunopathologically mediated rather than as a result of direct viral cytotoxicity.
Multi-Agent Distributed Service Restoration Scheme for Distribution Systems with Embedded Microgrids (2018)

This paper presents a multi-agent system (MAS) approach for automated service restoration for futuristic distribution systems with distributed energy resources (with/without microgrid forming capabilities). The proposed algorithm provides an architecture for interchangeable agent roles which is more robust and reliable compared to other approaches with rigid agent roles. The restoration algorithm is greedy (loosely based on distributed Prim's algorithm) to form the largest possible online sections. This helps improving system stability and makes it less susceptible to changing load/demand in the system by aggregation. The performance is demonstrated for a 33-bus distribution system with and without DERs. It is seen that algorithm always results in maximum possible loads be connected.
Failure Localization & Design Debug on Mixed-Mode ICs by Using the Dynamic Laser Stimulation Techniques (2007)

Abstract Soft defect localization techniques based on laser stimulation have become key techniques for a wide range of FA/debug issues. In this paper, we demonstrate the ability of these techniques to solve critical design issue in mixed-mode device for automotive application which includes analog, logic, RF and power. Utilizing a wide range of laser stimulation techniques, we have determined the most efficient approach for this device to achieve the shortest cycle time. We have established a clear link between fault isolation by laser stimulation techniques and the abnormal behavior of the device with relevant and complete simulation at transistor level.
FUNDAMENTAL AND CLINICAL ASPECTS OF ANTI NEUTROPHIL CYTOPLASMIC ANTIBODIES (ANCA) (1992)

Anti-neutrophil cytoplasmic antibodies (ANCA) are associated with different forms of both primary and secondary vasculitis and glomerulonephritis. These antibodies are directed against different enzymes located in granulocyte granules. In this review ANCA-related antigens and solid phase assays for ANCA detection will be discussed. Furthermore, we will address the clinical relevance of ANCA and will deliberate on their possible pathogenic implications.
Passivity of Martensite-Based Stainless Steel Oil Country Tubular Goods in Sour Environment (2016)

Passivity of the martensite-based stainless steels for oil country tubular goods, 15Cr (15Cr-6Ni-2Mo-1Cu) and 17Cr (17Cr-4Ni-2.5Mo-1Cu-1W), in an H2S environment were investigated. The depassivation pH of the 15Cr was around 3.2 to 3.5, and that of the 17Cr was around 3.0 in a 10% H2S environment. The difference in the depassivation pH between the 15Cr and the 17Cr corresponded to the difference in the applicable pH limits of the 15Cr and the 17Cr for sulfide stress cracking (SSC). It was suggested that depassivation is one of the dominant factors that determine the applicable limit for SSC. Analyses of the passivation film were also conducted to investigate the mechanism of the depassivation. Direct observation and analysis of the passivation film were successfully performed with a high-resolution transmission electron microscope. It was revealed that sulfur, which had originated from H2S in the environment, had penetrated into the passivation film. This led to the assumption that the penetration of sulfur into the passivation film relates to the deterioration of the passivation film, which would lead to the initiation of SSC. The resistance of the passivation film to the effect of sulfur could be a crucial factor in decreasing the SSC susceptibility in terms of passivity. The phase dependence of the passivity in the 17Cr was also discussed with regard to electrochemistry.
Fibrinolytic crosstalk with endothelial cells expands murine mesenchymal stromal cells (2016)

Tissue plasminogen activator (tPA), aside from its vascular fibrinolytic action, exerts various effects within the body, ranging from synaptic plasticity to control of cell fate. Here, we observed that by activating plasminogen and matrix metalloproteinase-9, tPA expands murine bone marrow-derived CD45(-)TER119(-)Sca-1(+)PDGFRα(+) mesenchymal stromal cells (PαS-MSCs) in vivo through a crosstalk between PαS-MSCs and endothelial cells. Mechanistically, tPA induces the release of Kit ligand from PαS-MSCs, which activates c-Kit(+) endothelial cells to secrete MSC growth factors: platelet-derived growth factor-BB (PDGF-BB) and fibroblast growth factor 2 (FGF2). In synergy, FGF2 and PDGF-BB upregulate PDGFRα expression in PαS-MSCs, which ultimately leads to PαS-MSC expansion. These data show a novel mechanism by which the fibrinolytic system expands PαS-MSCs through a cytokine crosstalk between niche cells.
Unrestrained Human Gait Motion Analysis of Healthy Subjects and Trans-Femoral Amputee Using Mobile Force Plate (2013)

In human gait motion analysis, which is one useful method for efficient physical rehabilitation, ground reaction forces, kinetic and kinematic parameters are measured. Recently, it is thought that trans-femoral amputees must regain moving pattern by refined rehabilitation program using loads applied on a prosthetic limb and understanding them is indispensable for gait analysis based on the biomechanical consideration of trans-femoral amputees. For obtaining these data as the unrestrained gait measurement, a novel gait motion analysis system using mobile force plate and attitude sensor has been developed. However, it has been used at only specially-cleaned experimental laboratory. In this study, ground reaction forces and joint moments applied on the lower limb of healthy subjects and trans-femoral amputee are measured and energy consumption is calculated under a wide range of environmental conditions including slope and stairs by the developed system. As a result of the experiments, the patterns of joint moments in the sagittal plane and energy consumption by them are obtained as the remarkably different feature quantities in addition to braking and propulsive forces among the five activities. Finally, the effectiveness of the developed system to analyze human biomechanics during gait and its quantitative evaluation based on those data is validated.
Simple and sensitive technique tor determining refractive nonlinearities (1989)

Nonlinear interferometry and beam profile distortion measurements have been commonly used to study nonlinear refraction in many materials. Interferometry is potentially sensitive but requires a relatively complex experimental apparatus. Beam distortion measurements, on the other hand, require precise beam scans followed by detailed wave propagation analysis. We present a novel method which offers simplicity as well as very high sensitivity in measuring and analyzing such nonlinearities.
ChemInform Abstract: New Synthesis of 4‐Azaphenothiazine. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Proliferative and Regenerative Effect of Acetonic Extract of Feijoa sellowiana on Stem Cells (2020)

The modulatory activity of Feijoa may be responsible for its increasing effect on cell proliferation till day 3<sup>rd</sup>. Therefore, when faster proliferation during a shorter time period is targeted, Feijoa can be safely added to the culture media in the first three days.
Endpoint-based parallel data processing in a parallel active messaging interface of a parallel computer (2023)

Endpoint-based parallel data processing in a parallel active messaging interface ('PAMI') of a parallel computer, the PAMI composed of data communications endpoints, each endpoint including a specification of data communications parameters for a thread of execution on a compute node, including specifications of a client, a context, and a task, the compute nodes coupled for data communications through the PAMI, including establishing a data communications geometry, the geometry specifying, for tasks representing processes of execution of the parallel application, a set of endpoints that are used in collective operations of the PAMI including a plurality of endpoints for one of the tasks; receiving in endpoints of the geometry an instruction for a collective operation; and executing the instruction for a collective opeartion through the endpoints in dependence upon the geometry, including dividing data communications operations among the plurality of endpoints for one of the tasks.
113 Murder on the HIV Express: Insights into How CD4 T Cells Are Killed in Lymphoid Tissues (2011)

The mechanism underlying CD4 T-cell depletion in HIV-infected hosts remains poorly understood. Loss of these cells underlies subsequent clinical development of AIDS. Both direct and indirect mechanisms of CD4 T cell killing have been proposed. In ex vivo cultures of primary human tonsil tissue, CD4 T cells undergo a dramatic cytopathic response following HIV infection. Strikingly, we find that 95% of these dying lymphoid cells are not productively infected with HIV but instead correspond to bystander cells that are abortively infected. Abortive infection reflects the non-permissive state of most resting CD4 T cells where the viral life cycle is arrested prior to the completion of reverse transcription. CD4 T cell killing is prevented by HIV entry and fusion inhibitors and by inhibitors that block the initiation of reverse transcription (NNRTI's including efavirenz and nevirapine). Conversely, RT inhibitors that act later in the reverse transcription process as chain terminators (NRTI's including AZT and 3TC) or inhibitors of viral integration (raltegravir) do not rescue CD4 T cells from this form of death. The accumulation of cytoplasmic viral DNA is sensed in these cells activating an innate immune reponse that ultimately culminates in death of the host cell. The nature of this innate response will be discussed. Together, these findings highlight how a protective host response centrally contributes to the demise of CD4 T cells during HIV infection ultimately culminating in AIDS.
La signature spatiale de l'objet : une information essentielle pour la localisation de cibles dans une scène naturelle (2004)

Giraudet Guillaume, Roumes Corinne. La signature spatiale de l'objet : une information essentielle pour la localisation de cibles dans une scène naturelle. In: L'année psychologique. 2004 vol. 104, n°1. pp. 9-49.
A Highly Selective and Practical Method for Enantiopure Sulfoxides Utilizing Activated and Functionally Differentiated N‐Sulfonyl‐1,2,3‐oxathiazolidine‐2‐oxide Derivatives (2003)

New, stereoselective, and general methods for the preparation enantiopure sulfoxides by using norephedrine tosylate as a chiral auxiliary are described. The product may be obtained either stepwise, or in a one-pot reaction (see scheme). Furthermore, the chiral template can be isolated from the reaction mixture and recycled. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2003/z50644_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Association of Endodontic Lesions with Coronary Artery Disease (2016)

An endodontic lesion (EL) is a common manifestation of endodontic infection where Porphyromonas endodontalis is frequently encountered. EL may associate with increased risk for coronary artery disease (CAD) via similar pathways as marginal periodontitis. The aim of this cross-sectional study was to delineate the associations between EL and CAD. Subgingival P. endodontalis, its immune response, and serum lipopolysaccharide were examined as potential mediators between these 2 diseases. The Finnish Parogene study consists of 508 patients (mean age, 62 y) who underwent coronary angiography and extensive clinical and radiographic oral examination. The cardiovascular outcomes included no significant CAD ( n = 123), stable CAD ( n = 184), and acute coronary syndrome (ACS; n = 169). EL was determined from a panoramic tomography. We combined data of widened periapical spaces (WPSs) and apical rarefactions to a score of EL: 1, no EL ( n = 210); 2, ≥1 WPS per 1 apical rarefaction ( n = 222); 3, ≥2 apical rarefactions ( n = 76). Subgingival P. endodontalis was defined by checkerboard DNA-DNA hybridization analysis, and corresponding serum antibodies were determined by ELISA. In our population, 50.4% had WPSs, and 22.8% apical rarefactions. A total of 51.2% of all teeth with apical rarefactions had received endodontic procedures. Subgingival P. endodontalis levels and serum immunoglobulin G were associated with a higher EL score. In the multiadjusted model (age, sex, smoking, diabetes, body mass index, alveolar bone loss, and number of teeth), having WPSs associated with stable CAD (odds ratio [OR] = 1.94, 95% confidence interval [95% CI] = 1.13 to 3.32, P = 0.016) and highest EL score were associated with ACS (OR = 2.46, 95% CI = 1.09 to 5.54, P = 0.030). This association was especially notable in subjects with untreated teeth with apical rarefactions ( n = 59, OR = 2.72, 95% CI = 1.16 to 6.40, P = 0.022). Our findings support the hypothesis that ELs are independently associated with CAD and in particular with ACS. This is of high interest from a public health perspective, considering the high prevalence of ELs and CAD.
Performance analysis of switch access systems (2002)

The public Internet and corporate intranets have been growing at a phenomenal rate in recent years. Today, the public switched telephone network (PSTN) is the most common mechanism for accessing the Internet and intranets from home. Thus, much of the data traffic is transported through traditional switch access systems. Until recently, traffic engineering for these switch access systems has been based on traffic models consisting predominantly of voice traffic. The current explosion in the amount of data traffic — with differing traffic characteristics — being transported by traditional switching systems may have an adverse impact on the grades of service (GoS) unless engineering rules are modified to account for the new traffic characteristics. While this issue is important for central office switches and inter-switch trunking, it is even more important for relatively smaller access concentrators. This paper compares simulation and analytical models that help in engineering such systems for a mix of traffic.
Synthetic Studies toward Mycobacterium tuberculosis Sulfolipid-I (2008)

Sulfolipid-I (SL-I) is an abundant metabolite found in the cell wall of Mycobacterium tuberculosis that is comprised of a trehalose 2-sulfate core modified with four fatty acyl substituents. The correlation of its abundance with the virulence of clinical isolates suggests a role for SL-I in pathogenesis, although its biological functions remain unknown. Here we describe the synthesis of a SL-I analogue bearing unnatural lipid substituents. A key feature of the synthesis was application of an intramolecular aglycon delivery reaction to join two differentially protected glucose monomers, one prepared with a novel alpha-selective glycosylation. The route developed for the model compound can be readily extended to the synthesis of native SL-I as well as additional analogues for use in the investigation of SL-I's functions.