gebhart/patrepeval huggingface dataset:
Abnormal cross-frequency coupling in the tinnitus network (2014)

Neuroimaging studies have identified networks of brain areas and oscillations associated with tinnitus perception. However, how these regions relate to perceptual characteristics of tinnitus, and how oscillations in various frequency bands are associated with communications within the tinnitus network is still incompletely understood. Recent evidence suggests that apart from changes of the tinnitus severity the changes of tinnitus dominant pitch also have modulating effect on the underlying neuronal activity in a number of brain areas within the tinnitus network. Therefore, in a re-analysis of an existing dataset, we sought to determine how the oscillations in the tinnitus network in the various frequency bands interact. We also investigate how changes of tinnitus loudness, annoyance and pitch affect cross-frequency interaction both within and between nodes of the tinnitus network. Results of this study provide, to our knowledge, the first evidence that in tinnitus patients, aside from the previously described changes of oscillatory activity, there are also changes of cross-frequency coupling (CFC); phase-amplitude CFC was increased in tinnitus patients within the auditory cortex and the dorsolateral prefrontal regions between the phase of delta-theta and the amplitude of gamma oscillations (Modulation Index [MI] 0.17 in tinnitus patients vs. 0.08 in tinnitus free controls). Moreover, theta phase in the anterior cingulate region modulated gamma in the auditory (MI 0.1) and dorsolateral prefrontal regions (MI 0.19). Reduction of tinnitus severity after acoustic coordinated reset therapy led to a partial normalization of abnormal CFC. Also treatment induced changes in tinnitus pitch significantly modulated changes in CFC. Thus, tinnitus perception is associated with a more pronounced CFC within and between nodes of the tinnitus network. CFC can coordinate tinnitus-relevant activity in the tinnitus network providing a mechanism for effective communication between nodes of this network.
Enhancement of the NAD(P)(H) Pool in Escherichia coli for Biotransformation (2007)

Abstract In pyridine nucleotide‐dependent, reductive whole cell biotransformation with resting cells of Escherichia coli , the availability of intracellular NAD(P)(H) is a pivotal point for an efficient and highly productive substrate conversion. The question whether an increase of the intracellular NAD(P)(H) concentration could increase the productivity was discussed controversially in the past. This is the first report on an E. coli strain with an increased NAD(P)(H) pool which was tested in a reductive biotransformation system for an increased productivity. Biotransformation was performed with a strain overexpressing a gene encoding an ( R )‐specific alcohol dehydrogenase for the stereospecific, NADPH‐dependent reduction of methyl acetoacetate (MAA) to ( R )‐methyl‐3‐hydroxybutanoate (MHB). Cofactor regeneration was implemented via glucose oxidation by coexpression of a gene encoding glucose dehydrogenase. The specific MHB productivity (mmol mg –1 cell dry weight –1 h –1 ) enabled a comparison between the E. coli BL21(DE3) wild‐type and a genetically modified strain. The enhancement of the NAD(P)(H) pool was achieved by genetic manipulation of the NAD(H) biosynthetic pathways. After simultaneous overexpression of the pncB and nadE genes, encoding nicotinic acid phosphoribosyltransferase and NAD synthetase, measurements of the total NAD(P)(H) pool, sizes showed a 7‐fold and 2‐fold increased intracellular concentration of NAD(H) and NADP(H), respectively. However, the implementation of an E. coli strain carrying a genomically integrated pncB gene with an upstream T7 promoter for biotransformation did not result in reproducible increased specific cell productivity.
Développement de phases monolithiques à base de dioxyde de titane pour la séparation et l’enrichissement des produits phosphorylés (2011)

Ce manuscrit est consacre a l’elaboration de phases monolithiques a base de dioxyde de titane pour les techniques separatives appliquees a l’analyse des produits phosphoryles. La partie bibliographique situe d’abord l’interet des monolithes pour le developpement des techniques separatives en portant une attention particuliere a la problematique de miniaturisation. L’etat de l’art sur l’utilisation du dioxyde de titane, dans les sciences separatives, est ensuite etabli. A ce niveau, les principales caracteristiques physico-chimiques et chromatographiques de ce materiau sont revues pour les lits particulaires. Un descriptif de la synthese des monolithes de dioxyde de titane par le procede sol-gel est ensuite detaille avant d’illustrer la mise en oeuvre de ce type de colonnes dans les techniques separatives. La partie experimentale est axee d’abord sur la comprehension du comportement du dioxyde de titane particulaire en chromatographie liquide a interaction hydrophile (HILIC). Le travail experimental est ensuite oriente vers l’elaboration d’un procede sol-gel repetable, permettant d’obtenir le materiau sous le format monolithique. Dans un premier temps, le support est elabore sous forme de barreau, dont l’utilisation potentielle apres mise en colonne est illustree dans le cadre de la purification et de l’enrichissement des acides amines phosphoryles. Des adaptations de protocole sont apportees pour la synthese in situ de ces monolithes a l’interieur des capillaires afin de repondre aux contraintes des techniques separatives miniaturisees. Ces monolithes sont caracterises en HILIC, par comparaison avec les phases particulaires. Pour terminer, les proprietes chromatographiques originales de ces phases sont mises a profit pour la separation et le traitement d’echantillons, contenant des produits phosphoryles
A practical traffic management system for integrated LTE-WiFi networks (2014)

Mobile operators are leveraging WiFi to relieve the pressure posed on their networks by the surging bandwidth demand of applications. However, operators often lack intelligent mechanisms to control the way users access their WiFi networks. This lack of sophisticated control creates poor network utilization, which in turn degrades the quality of experience (QoE). To meet user traffic demands, it is evident that operators need solutions that optimally balance user traffic across cellular and WiFi networks. Motivated by the lack of practical solutions in this space, we design and implement ATOM - an end-to-end system for adaptive traffic offloading for WiFi-LTE deployments. ATOM has two novel components: (i) A network interface selection algorithm that maps user traffic across WiFi and LTE to optimize user QoE and (ii) an interface switching service that seamlessly re-directs ongoing user sessions in a cost-effective and standards-compatible manner. Our evaluations on a real LTE-WiFi testbed using YouTube traffic reveals that ATOM reduces video stalls by 3-4 times compared to naive solutions.
Conformational polymorphism in a heteromolecular single crystal leads to concerted movement akin to collective rack-and-pinion gears at the molecular level (2008)

We describe a heteromolecular single crystal that exhibits three reversible and concerted reorganizations upon heating and cooling. The products of the reorganizations are conformational polymorphs. The reorganizations are postulated to proceed through three motions: (i) alkyl translations, (ii) olefin rotations, and (iii) rotational tilts. The motions are akin to rack-and-pinion gears at the molecular level. The rack-like movement is based on expansions and compressions of alkyl chains that are coupled with pinion-like 180 degree rotations of olefins. To accommodate the movements, phenol and thiophene components undergo rotational tilts about intermolecular hydrogen bonds. The movements are collective, being propagated in close-packed repeating units. This discovery marks a step to understanding how organic solids can support the development of crystalline molecular machines and devices through correlated and collective movements.
Artificial intelligence in knowledge management for time series forecasting (1997)

Knowledge Management (KM) is a keen topic for an organization, in particular to those that have to deal with knowledge acquired from different sources, either from its own experiences or from that of others, to decide on the effective use of that knowledge to fulfill the goals of the organization. As representative examples of KM, one may have the object-oriented data bases, hypermedia or concept maps. On the other hand, techniques developed in Artificial Intelligence for knowledge representation and discovery may be of great use in KM; in particular, it seems natural to explore the potential of the organization past data to deal with management decisions of the present. One way is to use Time Series Forecasting (TSF), where forecasts are based on pattern recognition of past observations ordered in time. Traditional TSF methods, such as the Holt-Winters and the Box-Jenkins ones, are based on particular characteristics of the Time Series (TS), such as trend or seasonal effects. These methods work with well behaved TS, but present some drawbacks on TS with noise or some unknown nonlinear relations among the TS data. An alternative approach is the use of Artificial Neural Networks (ANNs), which present two main advantages: ANNs can extrapolate patterns from past data, even in TS with noise, and may adapt their behavior as new data comes in. A problem with the use of this approach is the search time for the best ANN architecture, which involves a large searching space, demanding a huge computational effort. Other aspect of concern is that of TS data filtering. Not all lags of the TS have the same influence over the forecast. Feeding the ANN with a big time window will slow the ANN forecasting efficiency. To solve these pitfalls, one may use random search, hill climbing or genetic procedures. The last ones are known to work well on problems of combinatorial nature, obtaining good solutions where other methods seem to fail. This paper presents an integrated approach for TSF: a set of rules will create the training cases, based on some lags of the TS; these rules and the ANN parameters will be encoded on the genetic chromosomes; finally, each ANN will be trained, leading to competition.
Computer-based system for monitoring drug therapy (1988)

article Free Access Share on Computer-based system for monitoring drug therapy Authors: Stanley N. Cohen Stanford University School of Medicine Stanford University School of MedicineView Profile , Jing-Jing L. Kondo Stanford University School of Medicine Stanford University School of MedicineView Profile , Richard J. Mangini Stanford University School of Medicine Stanford University School of MedicineView Profile , Terrence N. Moore Stanford University School of Medicine Stanford University School of MedicineView Profile , Ann Barry Flood Stanford University School of Medicine Stanford University School of MedicineView Profile Authors Info & Claims ACM SIGBIO NewsletterVolume 10Issue 4Dec. 1988 pp 23–27https://doi.org/10.1145/62171.62174Online:01 December 1988Publication History 0citation50DownloadsMetricsTotal Citations0Total Downloads50Last 12 Months2Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Hereditary transthyretin amyloidosis: baseline characteristics of patients in the NEURO-TTR trial (2018)

Baseline data from the NEURO-TTR trial demonstrates ATTRm amyloidosis as a systemic disease with deficits in multiple organs and body systems, leading to decreased quality of life. We report concomitant presentation of polyneuropathy and cardiomyopathy in most patients, and early involvement of multiple body systems.
Red-Emitting Dibenzodiazepinone Derivatives as Fluorescent Dualsteric Probes for the Muscarinic Acetylcholine M2 Receptor (2020)

Fluorescently labeled dibenzodiazepinone-type muscarinic acetylcholine receptor (MR) antagonists, including dimeric ligands, were prepared using red-emitting cyanine dyes. Probes containing a fluorophore with negative charge showed high M<sub>2</sub>R affinities (p<i>K</i><sub>i</sub> (radioligand competition binding): 9.10-9.59). Binding studies at M<sub>1</sub> and M<sub>3</sub>-M<sub>5</sub> receptors indicated a M<sub>2</sub>R preference. Flow cytometric and high-content imaging saturation and competition binding (M<sub>1</sub>R, M<sub>2</sub>R, and M<sub>4</sub>R) confirmed occupation of the orthosteric site. Confocal microscopy revealed that fluorescence was located mainly at the cell membrane (CHO-hM<sub>2</sub>R cells). Results from dissociation and saturation binding experiments (M<sub>2</sub>R) in the presence of allosteric M<sub>2</sub>R modulators (dissociation: W84, LY2119620, and alcuronium; saturation binding: W84) were consistent with a competitive mode of action between the fluorescent probes and the allosteric ligands. Taken together, these lines of evidence indicate that these ligands are useful fluorescent molecular tools to label the M<sub>2</sub>R in imaging and binding studies and suggest that they have a dualsteric mode of action.
Acquisition and reversal in the procedural T-maze. (2015)

&lt;p&gt;In the procedural T-maze mice are trained to reach a platform on one side of the maze. After they perform correctly 6 out of 8 trials in two consecutive days, the platform position is reversed and mice are trained under the new rule. A: The proportion of mice that reached criteria during the acquisition (maximum 8 days) shows that there were no deficits in the 16p11.2 df/+ mice but Cntnap2 -/- mice learned the task faster; B: during reversal (6 days maximum) there were no deficits either. Note the reversal data for Cntnap2 WT mice are identical to that of the Cntnap2 -/- mice. Data shown are proportions of mice that started the task (Genotype Factor, Survival Analysis, Chi Square: **p &lt; .01).&lt;/p&gt;
Session 3 Device technology &#8212; Insulators and isolation (1982)

Start of the above-titled section of the conference proceedings.
A1151. PATIENT-SPECIFIC 3-D BONE MODEL RECONSTRUCTION FROM X-RAY FLUOROSCOPY (2011)

An accurate geometrical three-dimensional (3D) model of human bone is required in many medical procedures including Total Knee Arthroplasty (TKA) and computer-assisted surgical navigation. Segmentation of Computed Tomography (CT) datasets is commonly used to obtain such models. However, such a method is expensive and time consuming. We herein propose a novel method for patient specific bone model reconstruction using standard x-ray fluoroscopy, a cheaper and widely available imaging alternative. Fluoroscopic images are taken at multiple arbitrary viewpoints to provide sufficient information for bone reconstruction. The viewpoints can be obtained by either rotating the imaging source and detector or the patient’s limb of interest. The bone’s pose within the radiological scene in each of the captured images can be estimated by tracking a set of metallic calibration markers within a calibration target, rigidly attached to the limb of interest. Having acquired the required calibration data, a complex iterative scheme is executed to optimize a statistical bone atlas of the bone of interest and the relative pose between the bone and the calibration target. In order to verify our method, we performed a cadaveric study. A set of rigidly attached fiducial markers were attached to a cadaveric leg. The leg was imaged using x-ray fluoroscopy while being rotated axially to provide us with the images required for bone model reconstruction. Distal femur and proximal tibia bone models were reconstructed from the fluoroscopy images. Furthermore, the leg was CT-scanned and segmented to provide us with the ground-truth required for reconstruction accuracy assessment. Results show the adequacy of the proposed method for surgical applications.
Message passing with queues and channels (2023)

In an embodiment, a reception thread receives a source node identifier, a type, and a data pointer from an application and, in response, creates a receive request. If the source node identifier specifies a source node, the reception thread adds the receive request to a fast-post queue. If a message received from a network does not match a receive request on a posted queue, a polling thread adds a receive request that represents the message to an unexpected queue. If the fast-post queue contains the receive request, the polling thread removes the receive request from the fast-post queue. If the receive request that was removed from the fast-post queue does not match the receive request on the unexpected queue, the polling thread adds the receive request that was removed from the fast-post queue to the posted queue. The reception thread and the polling thread execute asynchronously from each other.
Modified—Hill-determinant method for the hydrogen molecular-ion problem (1983)

The problem of the ${\mathrm{H}}_{2}$ molecular ion is reinvestigated with the use of a method of truncated Hill determinants. Modified Hill determinants are found such that the truncations thereof form a convergent sequence. The wave functions obtained from the present formulation are expected to be more reliable than those reported earlier and in fact are shown to be orthonormal to one part in ${10}^{6}$. Equilibrium bond lengths (${R}_{e}$), stiffness constants, and the wave functions at ${R}_{e}$ for various states are presented.
Image quality improvement in inspection systems using double integrator illumination (2007)

The most annoying problem accompanying production of high-fidelity pattern images in mask defect inspection systems is the generation of virtual images in the imaging process. The focused image pattern on the image acquisition sensor has two images, one true and one virtual. The virtual images are generated under Kohler's illumination using an integrator. The theoretical cause of this virtual image is the periodicity of the integrator. The improvement of image quality gives the mask defect inspection system higher defect detection sensitivity. To reduce virtual images, the double integrator method is applied to the illumination optics. By adopting the double integrator illumination method, virtual images disappear in the imaging field. Further, since this also lowers the power density at bright spots, the interference of lenses in working environments at the aperture stop position between objective imaging lenses is greatly reduced. This paper reports a method by which the ill effects of image quality improvement in the mask defect inspection system can be dramatically reduced. The simulation results when this method is applied to an advanced mask defect inspection system are shown.
Supplementary Materials, Figures 1 - 2, Table 1 from The RAD51-Stimulatory Compound RS-1 Can Exploit the RAD51 Overexpression That Exists in Cancer Cells and Tumors (2023)

&lt;p&gt;PDF file - 403KB, Supplemental Figure 1. Quantifications of western blots. Supplemental Figure 2. Knockdown of RAD51 in PC3 does not protect cells from the toxicity of ionizing radiation. Supplemental Table 1. Quantifications of statistical significance are displayed for the RS-1 toxicity data that are displayed in Figure 2. Supplemental Methods. Chemical synthesis of compounds.&lt;/p&gt;
Evaluating a scatterometry-based focus monitor technique for hyper-NA lithography (2007)

This paper discusses the use of scatterometry for scanner focus control in hyper-NA lithography. A variety of techniques based on phase shift technology have been traditionally used to monitor scanner focus. Recently scatterometry has offered significant promise as an alternate technique to monitor both focus and dose. In this study, we make careful comparisons of a Scatterometry-based Focus-Dose Monitoring (SFDM) technique to Phase-grating Focus Monitoring (PGFM). We discuss the operating principles of these techniques and compare the sensitivity of SFDM to PGFM. In addition, the variation observed in characterizing intra-field and across-wafer behavior of a hyper-NA immersion scanner is described when using these different techniques.
In vivo efficacy investigations of an siRNA-containing nanoparticle formulation targeting the m2 subunit of ribonucleotide reducatse (rrm2) in tumor-bearing mice (2008)

1382 Calando Pharmaceuticals is developing siRNA-containing nanoparticle formulations and its leading formulation that will enter the clinic in 2008 contains the human transferrin protein as a targeting ligand and siRNA targeting the M2 subunit of ribonucleotide reductase (RRM2). As part of the pre-clinical investigations, a number of in vivo studies of this formulation in mice have been performed to determine the effects of dose level, dose schedule, and tumor type (e.g., HCC, melanoma, etc.) on efficacy. The results of these studies will be presented and include evidence of tumor growth delay and tumor regression. Efficacy is only obtained when the targeted version of the nanoparticles are employed. Results from numerous studies will be provided to support the claim that RRM2 inhibition by the RNAi mechanism (RACE analyses) is the cause of the tumor growth suppression rather than other off target effects.
Proposed Measured Display Characterization File for HDR Consumer Displays (2017)

The advent of wide color gamut (WCG) and high dynamic range (HDR) imaging has upended long-established standards for display monitors and changed the very definition of display calibration. With the ITU-R BT.709 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> standard, which in retrospect looks like a calm and pastoral monoculture, the nature of display calibration was straightforward: adjust the behavior of the video display until its output matched the standard as closely as possible. — The changes created by HDR can be seen most clearly by describing the way HDR color volume mapping works: An HDR TV's color volume-mapping algorithm looks at the metadata that shows how the content was mastered, compares that metadata to the definition of the HDR TV's capabilities, and applies some very intelligent mapping to make the HDR content appear as accurately as possible on the TV. — A new kind of calibration process is needed to provide color accuracy, while at the same time not affecting the intended behavior of the TV's Color Volume Remapping algorithm. No standard exists for the format or mechanism of this process. This paper proposes a standard for selfdescription in video displays that will allow mapping algorithms to best display a variety of HDR content on a variety of display devices with differing capabilities.
Erratum to: Measurement of $$\psi (2S)$$ meson production in pp collisions at $$\sqrt{s}=7\,\hbox {TeV}$$ (2020)

This erratum corrects measurements of the prompt and secondary (from- b ).