gebhart/patrepeval huggingface dataset:
The clinical outcome of minimally invasive Phase 3 Oxford unicompartmental knee arthroplasty (2015)

There have been concerns about the long-term survival of unicompartmental knee arthroplasty (UKA). This prospective study reports the 15-year survival and ten-year functional outcome of a consecutive series of 1000 minimally invasive Phase 3 Oxford medial UKAs (818 patients, 393 men, 48%, 425 women, 52%, mean age 66 years; 32 to 88). These were implanted by two surgeons involved with the design of the prosthesis to treat anteromedial osteoarthritis and spontaneous osteonecrosis of the knee, which are recommended indications. Patients were prospectively identified and followed up independently for a mean of 10.3 years (5.3 to 16.6). At ten years, the mean Oxford Knee Score was 40 (standard deviation (sd) 9; 2 to 48): 79% of knees (349) had an excellent or good outcome. There were 52 implant-related re-operations at a mean of 5.5 years (0.2 to 14.7). The most common reasons for re-operation were arthritis in the lateral compartment (2.5%, 25 knees), bearing dislocation (0.7%, seven knees) and unexplained pain (0.7%, seven knees). When all implant-related re-operations were considered as failures, the ten-year rate of survival was 94% (95% confidence interval (CI) 92 to 96) and the 15-year survival rate 91% (CI 83 to 98). When failure of the implant was the endpoint the 15-year survival was 99% (CI 96 to 100). This is the only large series of minimally invasive UKAs with 15-year survival data. The results support the continued use of minimally invasive UKA for the recommended indications.
Preparation and cation complexing properties of some macropolycyclic ligands (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and cation complexing properties of some macropolycyclic ligandsKrzysztof E. Krakowiak, Jerald S. Bradshaw, N. Kent Dalley, Chengyue Zhu, Guoliang Yi, Janet C. Curtis, Du Li, and Reed M. IzattCite this: J. Org. Chem. 1992, 57, 11, 3166–3173Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published inissue 1 May 1992https://doi.org/10.1021/jo00037a038RIGHTS & PERMISSIONSArticle Views208Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
9-02: First Report On Communicating Leadless Anti-Tachycardia Pacemaker And Subcutaneous Implantable Defibrillator - The Next Step In Cardiac Rhythm Management (2016)

Introduction: With the aim of eliminating lead and pocket related complications, we examine the next step in multi-component leadless cardiac rhythm management (CRM): feasibility of an anti-tachycardia (ATP) leadless cardiac pacemaker (LCP), commanded by an implanted S-ICD through wireless, intra-body, device-device communication.
Rate, Risk Factors and Outcomes of Recurrence of Crohnʼs Disease After Total Colectomy with Permanent Ileostomy: a Systematic Review and Meta-analysis (2016)

Introduction: Total colectomy with permanent ileostomy (TC-PI) may be a treatment option in patients with medically refractory colonic Crohn's disease (CD). We performed a systematic review and metaanalysis to evaluate the rate, risk factors and outcomes of small bowel CD recurrence after TC-PI. Methods: Through a systematic review of multiple electronic databases, through March 31, 2016, we identified 18 cohort studies including 1438 adults who underwent TC-PI for colonic CD (median follow-up, 7.4 years; IQR, 5.3-9.0 years). We estimated pooled rates (with 95% confidence interval [CI]) of clinical and surgical recurrence, reoperation for stoma complications, as well as risk factors for disease recurrence. Results: On meta-analysis, the risk of clinical recurrence was 28% (95% CI, 21.7-35.3; 14 studies, 260/1004 patients; I2=80%), with a 5- and 10-year median cumulative rate of 23.5% (range, 7-35) and 40% (range, 11-60), respectively (Figure 1). The risk of surgical recurrence was 16.0% (95% CI, 11.1-22.7; 10 studies; 183/1092 patients; I2=84%), with a 5- and 10-year median cumulative rate of 10% (range, 3-29) and 18.5% (range, 14-34), respectively (Figure 2). Rate of reoperation for stoma complication was 15.6% (95% CI, 8.5-27.0; 7 studies; 108/701 patients). Rates of clinical recurrence were similar among studies published before (prior to 1998) and after the advent of biologics (26.9% vs. 30.0%, p=0.64). Presence of ileal disease at time of TC-PI was associated with 3.2 times higher risk of disease recurrence (RR, 3.2; 95% CI, 1.8-5.6); the risk of clinical and surgical recurrence in patients without ileal disease at the time of surgery was 23.5% (95% CI, 15.7-38.3) and 10.1% (95% CI, 5.7-17.5%), respectively. Other risk factors for disease recurrence were penetrating disease and young age at disease onset.Figure 1Figure 2Conclusion: Small bowel clinical recurrence occurs in about 28% patients after TC-PI for colonic CD. Disease recurrence risk is 3.2 times higher in patients with known ileal disease at time of surgery, and continued medical therapy is advisable in this population. In patients without ileal disease at surgery, continued endoscopic surveillance may identify asymptomatic disease recurrence to guide therapy.
Nerve Stimulation (2006)

Abstract This chapter describes electrical activation of the nervous system with an emphasis on stimulation of peripheral nerve fibers. Electrical stimulation of the nervous system is a widespread method to study the form and function of the nervous system and a technique to restore function following disease or injury. The objective of this chapter is to present the fundamental principles underlying nerve fiber excitation, and the focus is on electrical stimulation of peripheral myelinated nerve fibers. The fundamental understanding provided by quantitative analysis is required for rational design and interpretation of therapies employing electrical stimulation.
Joint Communication and Computation in Hybrid Cloud/Mobile Edge Computing Networks (2022)

Facing a vast amount of connections, huge performance demands, and the need for reliable connectivity, the sixth generation of communication networks (6G) is envisioned to implement disruptive technologies that jointly spur connectivity, performance, and reliability. In this context, this paper proposes, and evaluates the benefit of, a hybrid central cloud (CC) computing and mobile edge computing (MEC) platform, especially introduced to balance the network resources required for joint communication and computation. Consider a hybrid cloud and MEC system, where several power-hungry multi-antenna unmanned aerial vehicles (UAVs) are deployed at the cell-edge to boost the CC connectivity and relieve part of its computation burden. While the multi-antenna base stations are connected to the cloud via capacity-limited fronthaul links, the UAVs serve the cell-edge users with limited power and computational capabilities. The paper then considers the problem of maximizing the weighted network sum-rate subject to per-user delay, computational capacity, and power constraints, so as to determine the beamforming vectors and computation allocations. Such intricate non-convex optimization problem is tackled using an iterative algorithm that relies on $\ell_{0}$-norm relaxation, successive convex approximation, and fractional programming, and has the compelling ability to be implemented in a distributed fashion across the multiple UAVs and the CC. The paper results illustrate the numerical prospects of the proposed algorithm for enabling joint communication and computation, and highlight the appreciable improvements of data processing delays and throughputs as compared to conventional system strategies.
Translational Research: Moving Discovery to Practice (2007)

In the first week of October, I announced the launch of a national consortium that will transform how clinical and translational research is conducted; ultimately enabling researchers to provide new treatments more efficiently and quickly to patients. This new consortium, funded through Clinical and Translational Science Awards (CTSAs), begins with 12 academic health centers (AHCs) located throughout the nation. An additional 52 AHCs are receiving planning grants to help them prepare to apply for a CTSA.
Monolithic InP 16-QAM Modulator (2008)

We propose a novel optical 16-quadrature amplitude modulation (QAM) modulator and demonstrate it at 43 Gb/s. The modulator is monolithic in InP and is only 3.1 mm long.
Amino Acid Backbone Specificity of the Escherichia coli Translation Machinery (2004)

Using a pure Escherichia coli translation system, we tested the intrinsic specificity of the protein biosynthetic machinery by determining the relative yields of peptide synthesis for incorporation of a series of acyl-%@mt;sys@%tRNA%@sx@%GAC%@be@%AsnB%@sxx@%%@mx@% 's with varied backbone structures at the sense codon GUU (Val). The results showed that different amino acids on the same tRNA adaptor give significantly different peptide yields and the potential for cross-talk between the amino acid and tRNA body/anticodon in aa-tRNA decoding by the ribosome. They further support the substrate plasticity of the ribosomal biosynthetic machinery and provide immediate candidates for ribosomally encoded polymer synthesis.
New developments in transient elastography (2006)

An ultra-high-rate ultrasonic scanner has been developed that can give 5000 ultrasonic images per second of the body. With such a high frame rate, the propagation of transient shear waves can be followed, and from the spatio-temporal evolution of the displacement fields, various inversion algorithms allow us to recover the shear modulus map. A discussion on the various inversion algorithms will be presented. In order to obtain unbiased shear elasticity map, different configurations of shear sources induced by radiation pressure of focused transducer arrays are used. Both 2-D and 3-D imaging can obtained with this technique. In vitro and in vivo results on breast will be presented that demonstrate the interest of elasticity imaging with transient elastography.
Antibody Response of Ewes and does to Chimeric Sheep-Goat Pregnancy1 (1993)

Antibody production was evaluated in 62 recipients of blastomere-aggregation sheep-goat embryos, including 23 multiparous ewes, 21 multiparous does, 16 primiparous does, and 2 virgin does. The reactivity of sera collected weekly after the embryo transfer surgery was compared to that of sera collected prior to the embryo transfer by means of 1) complement-dependent cytotoxicity tests against peripheral blood lymphocytes (PBLs) from the parents of the embryo(s) and from random-bred sheep and goats, 2) hemagglutination and hemolytic assays with red blood cells (RBCs) from the two sires of the embryo(s), and 3) assays with PBLs and RBCs following absorptions with RBCs and PBLs from the parents and offspring. Although cross-reactivity to ovine and caprine PBL antigens was present in the control sera of some recipients, xenogeneic immunization during pregnancy was detected in 20 of 30 recipients that experienced term pregnancy. The xenogeneic response involved the production of antibody that reacted with both PBLs and RBCs. Allogeneic responses to RBCs were not observed, but allogeneic responses to PBLs occurred frequently, beginning after the onset of the xenogeneic response in most recipients (98 +/- 28 vs. 57 +/- 15 days in ewes; 93 +/- 23 vs. 46 +/- 7 days in does; mean day of onset +/- SD). The onsets of the responses were examined in conjunction with data collected on fetal and placental chimerism to evaluate possible routes of immunization. The onsets of the allogeneic responses and the limited serum reactivity to third-party PBLs suggested that fetal lymphocytes leaking across the placenta immunized the recipients to parentally inherited polymorphic antigens. The xenogeneic responses were associated with placental chimerism and appeared to involve the recognition of a species-specific monomorphic antigen shared by PBLs and RBCs. Neither of the responses appeared to affect continuation of pregnancy to term.
A DNA Vaccine against Chikungunya Virus Is Protective in Mice and Induces Neutralizing Antibodies in Mice and Nonhuman Primates (2011)

Chikungunya virus (CHIKV) is an emerging mosquito-borne alphavirus indigenous to tropical Africa and Asia. Acute illness is characterized by fever, arthralgias, conjunctivitis, rash, and sometimes arthritis. Relatively little is known about the antigenic targets for immunity, and no licensed vaccines or therapeutics are currently available for the pathogen. While the Aedes aegypti mosquito is its primary vector, recent evidence suggests that other carriers can transmit CHIKV thus raising concerns about its spread outside of natural endemic areas to new countries including the U.S. and Europe. Considering the potential for pandemic spread, understanding the development of immunity is paramount to the development of effective counter measures against CHIKV. In this study, we isolated a new CHIKV virus from an acutely infected human patient and developed a defined viral challenge stock in mice that allowed us to study viral pathogenesis and develop a viral neutralization assay. We then constructed a synthetic DNA vaccine delivered by in vivo electroporation (EP) that expresses a component of the CHIKV envelope glycoprotein and used this model to evaluate its efficacy. Vaccination induced robust antigen-specific cellular and humoral immune responses, which individually were capable of providing protection against CHIKV challenge in mice. Furthermore, vaccine studies in rhesus macaques demonstrated induction of nAb responses, which mimicked those induced in convalescent human patient sera. These data suggest a protective role for nAb against CHIKV disease and support further study of envelope-based CHIKV DNA vaccines.
Non-Isocyanate Polyurethane Bio-Foam with Inherent Heat and Fire Resistance (2022)

Polyurethanes (PUs) are versatile and widespread, particularly as flexible and rigid foams. To avoid isocyanates and other toxic reagents required for synthesis, such as phosgene, alternative synthetic routes have been utilized to produce non-isocyanate polyurethanes (NIPUs). A thermally and flame-resistant rigid NIPU was produced from environmentally benign and bio-sourced ingredients, requiring no catalyst or solvents. A foamed structure was obtained by the addition of glutaraldehyde and four different carboxylic acids: malic acid, maleic acid, citric acid, and aconitic acid. The resulting morphology, thermal degradation, and flame resistance of each foam were compared. The properties vary with each carboxylic acid used, but in each case, peak thermal degradation and peak heat release are postponed by >100 °C compared to commercial rigid PU foam. Furthermore, in a butane torch test, NIPU foams exhibit an 80% higher remaining mass and a 75% reduction in afterburn time, compared to commercial polyurethane. This bio-based polyurethane eliminates the hazards of traditional PUs, while imparting inherent thermal stability and flame resistance uncharacteristic of conventional foams.
Asymmetry of pressure autoregulation after traumatic brain injury (2003)

The left-right difference in autoregulation is significantly associated with a fatal outcome. Autoregulation in the brain is worse on the side ipsilateral to the lesion and on the side of expansion in cases in which there is a midline shift.
CFD-modelling of Selective Non-Catalytic Reduction of NO<SUB align=right>x in grate-kiln plants (2010)

The overall goal of this project is to find out if Selective Non-Catalytic Reduction (SNCR) technologies can be used in grate-kiln plants for NOx reduction. The technique has, to the best knowledge of the authors, never been used in this context before, despite that it is commonly used in cement and waste incineration plants. A model for spray injection into the grate was included in the model enabling a study of the overall mixing between the injected reagent droplets and the NOx polluted air. The simulations indicate that the SNCR-technique works with urea, but not with ammonia.
Ku-Band Cascode Balanced SiGe Power Amplifier with High Robustness to Active SWR (2021)

This paper presents the first efficient Ku-Band SiGe cascode power amplifier (PA) with a highly robust power combination to the active SWR. Two twisted couplers distribute 70.2um <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> emitter area in a balanced architecture to achieve reduced impedance transformation through baluns. As proof of concept, the PA was simulated with the 0.13-um SiGe BiCMOS technology. The post layout simulations show a saturated power (Psat) of 25.6dBm and a peak PAE of 30% at 18GHz and 90°C. With a 2:1 SWR the PAE and Pout drop less than 5.5% and 1.1dBm, respectively.
A generalized framework for medical image classification and recognition (2015)

In this work, we study the performance of a two-stage ensemble visual machine learning framework for classification of medical images. In the first stage, models are built for subsets of features and data, and in the second stage, models are combined. We demonstrate the performance of this framework in four contexts: 1) The public ImageCLEF (Cross Language Evaluation Forum) 2013 medical modality recognition benchmark, 2) echocardiography view and mode recognition, 3) dermatology disease recognition across two datasets, and 4) a broad medical image dataset, merged from multiple data sources into a collection of 158 categories covering both general and specific medical concepts—including modalities, body regions, views, and disease states. In the first context, the presented system achieves state-of-art performance of 82.2% multiclass accuracy. In the second context, the system attains 90.48% multiclass accuracy. In the third, state-of-art performance of 90% specificity and 90% sensitivity is obtained on a small standardized dataset of 200 images using a leave-one-out strategy. For a larger dataset of 2,761 images, 95% specificity and 98% sensitivity is obtained on a 20% held-out test set. Finally, in the fourth context, the system achieves sensitivity and specificity of 94.7% and 98.4%, respectively, demonstrating the ability to generalize over domains.
Enzyme-catalyzed organic synthesis: NAD(P)H regeneration using dihydrogen and the hydrogenase from Methanobacterium thermoautotrophicum (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnzyme-catalyzed organic synthesis: NAD(P)H regeneration using dihydrogen and the hydrogenase from Methanobacterium thermoautotrophicumChi-Huey Wong, Lacy Daniels, William H. Orme-Johnson, and George M. WhitesidesCite this: J. Am. Chem. Soc. 1981, 103, 20, 6227–6228Publication Date (Print):October 1, 1981Publication History Published online1 May 2002Published inissue 1 October 1981https://pubs.acs.org/doi/10.1021/ja00410a049https://doi.org/10.1021/ja00410a049research-articleACS PublicationsRequest reuse permissionsArticle Views241Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder (2014)

NBEA encodes neurobeachin, a scaffolding protein primarily expressed in the brain and involved in trafficking of vesicles containing neurotransmitter receptors. This locus has not previously been implicated in migraine per se. We found no evidence of association in data from the GWAS migraine meta-analysis consortium (n=118,710 participants) suggesting that the association might be specific to migraine co-morbid with bipolar disorder.
Plasminogen Activator Inhibitor-1 (PAI-1) 4G/5G Polymorphism, Coronary Thrombosis, and Myocardial Infarction in Middle-aged Finnish Men who Died Suddenly (2000)

High plasminogen activator inhibitor-1 (PAI-1) plasma levels increase future risk of myocardial infarction (MI). The 4G allele of the 4G/5G polymorphism of the PAI-1 gene has been associated with increased plasma levels of PAI-1. The association of the PAI-1 polymorphism with coronary narrowings, coronary thrombosis and myocardial infarction (MI) was studied in a prospective autopsy series of 300 middle-aged Caucasian Finnish men (33 to 69 yrs) suffering sudden out-of-hospital death (Helsinki Sudden Death Study). The 4G allele was found in 76.8% of men with sudden cardiac death (SCD) compared to 67.5% in men who died accidentally and 63.2% in men who died of other diseases (p = 0.08 and p = 0.055, respectively). Men possessing the 4G allele had more often acute MI (OR 3.5; p <0.05) and coronary thrombosis (OR 5.5. p = 0.01) compared to 5G homozygotes. 5G homozygotes, comprising one third of the men in our study, seem to be at a decreased risk of thrombosis, whereas carriers of the common 4G allele have an increased risk of thrombosis, AMI and possibly SCD compared to 5G homozygotes.
Scheme for realizing a photon number amplifier (1994)

A scheme for realizing a photon number amplifier by use of a high-quantum-efficiency photodetector and a number-state semiconductor laser is analyzed. It is found that the photon number amplifier is not significantly limited by the electronic amplifier noise or by the laser quantum efficiency for input states that are nearly classical.