gebhart/patrepeval huggingface dataset:
A synthesis of taxusin (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA synthesis of taxusinRobert A. Holton, R. R. Juo, Hyeong B. Kim, Andrew D. Williams, Shinya. Harusawa, Richard E. Lowenthal, and Sadamu. YogaiCite this: J. Am. Chem. Soc. 1988, 110, 19, 6558–6560Publication Date (Print):September 1, 1988Publication History Published online1 May 2002Published inissue 1 September 1988https://pubs.acs.org/doi/10.1021/ja00227a043https://doi.org/10.1021/ja00227a043research-articleACS PublicationsRequest reuse permissionsArticle Views3471Altmetric-Citations112LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Array comparative genomic hybridization identifies a heterozygous deletion of exon 3 of theRYR2gene (2015)

The aCGH method offers significant advantages over MLPA in genetic screening for heritable cardiac disorders.
4DCT image-based lung motion field extraction and analysis (2008)

Respiratory motion is a complicating factor in radiation therapy, tumor ablation, and other treatments of the thorax and upper abdomen. In most cases, the treatment requires a demanding knowledge of the location of the organ under investigation. One approach to reduce the uncertainty of organ motion caused by breathing is to use prior knowledge of the breathing motion. In this work, we extract lung motion fields of seven patients in 4DCT inhale-exhale images using an iterative shape-constrained deformable model approach. Since data was acquired for radiotherapy planning, images of the same patient over different weeks of treatment were available. Although, respiratory motion shows a repetitive character, it is well-known that patient's variability in breathing pattern impedes motion estimation. A detailed motion field analysis is performed in order to investigate the reproducibility of breathing motion over the weeks of treatment. For that purpose, parameters being significant for breathing motion are derived. The analysis of the extracted motion fields provides a basis for a further breathing motion prediction. Patient-specific motion models are derived by averaging the extracted motion fields of each individual patient. The obtained motion models are adapted to each patient in a leave-one-out test in order to simulate motion estimation to unseen data. By using patient-specific mean motion models 60% of the breathing motion can be captured on average.
45 GW pulsed-power generator (2007)

The construction of a 45 GW pulsed-power generator with an impedance of 2 Ω is presented. The generator can deliver a rectangular pulse of 300 kV with duration of 200 ns across a matched load. The generator is designed to be able to deliver a voltage of 500 kV into a 10 Ω unmatched load with an electric power of 25 GW. The primary energy storage of the generator consists of a 50 kV, 20 kJ capacitor bank. The 50 kV is discharged into a 1:12 transformer that charges a pulse-forming line to 600 kV. When charged, the pulse-forming line is discharged into the load via a spark gap. The transformer is of the type transmission-line-like where the high-voltage and low-voltage windings consists of high-voltage cables that are interleaved wounded. The pulse-forming line consists of 8x40 m long 110-kV coaxial cables, where both ends are connected to the load. Each cable is grounded at 20 m and connected in parallel. The cables have a characteristic impedance of 31 Ω and the parallel set-up makes the pulse-forming line impedance 2 Ω. The total length, height and width of the pulse generator are 4 m, 2 m and 1.2 m respectively.
Identification of a Variable Region within the Cytoplasmic Tail of the IL-2 Receptor β Chain That Is Required for Growth Signal Transduction (1995)

Interleukin-2 (IL-2) regulates numerous biological events, including T lymphocyte proliferation. Interleukin-2 receptor (IL-2R)-mediated signaling is triggered by ligand-induced heterodimerization of the IL-2R beta and gamma c subunits, which results in the activation of signaling intermediates that are associated with either IL-2R beta or gamma c. Previous mutagenesis studies of the IL-2R beta cytoplasmic tail demonstrated that the partially conserved box 1 and box 2 motifs and specific tyrosine residues are critical for growth signaling. By deletion and alanine scanning mutagenesis, another set of residues that are critical for IL-2R-mediated signaling has now been identified. These residues lie within the divergent 35-amino acid "spacer" region separating box 1 and box 2. The role of this receptor subregion in early phases of IL-2R signaling was evaluated using BA/F3 stable cell lines expressing three functionally impaired mutants from this region. All three cell lines displayed substantially diminished growth responsiveness to IL-2. Receptor-mediated STAT factor activation, IL-2R beta phosphorylation, and Janus kinase activation were also markedly impaired. These findings indicate that this variable spacer region, which we have termed the V-box, is essential for the initiation of IL-2R-mediated signal transduction.
Spatial-Motor Flexibility (SMF) and Post-Stroke Cognitive Recovery (P6.014) (2016)

Objective: We sought to learn whether a critically important component of spatial-motor Aiming ability, spatial-motor flexibility (SMF)--defined as the ability to spatially shift, focus and direct movement--is independently associated with post-stroke functional recovery. Background:Post-stroke spatial neglect, a problem reporting, responding or orienting to contralesional space, causing functional deficits, may cause both spatial “Where” perceptual-attentional errors of, visual awareness, and spatial-motor “Aiming errors". Spatial-motor Aiming neglect is often overlooked and associated with significant functional deficits, affecting adaptive movements in daily life. Methods:We studied whether SMF, as measured by performance of the clicking test--a practical bedside test assessing the ability to execute swift movements of the ipsilesional hand in the neglected, left hemispace compared to the right hemispace--predicted the rate of functional independence recovery in 126 right stroke survivors. Results:Subjects with and without SMF deficits (hemispatial hypokinesia) had similar spatial neglect severity (mean Catherine Bergego Scale ±SD, 16 ±8 versus 14 ±8), and Functional Independence Measure (FIM)motor efficiency (0.67 versus 0.75). However, patients with greater SMF deficits demonstrated significantly slower improvement of functional cognitive independence (FIM-Cognitive efficiency; 0.14 versus 0.24, p < 0.01). Conclusions:The ability to direct movement flexibly in the side of body-centered space near impaired limbs may be needed for optimal functional stroke recovery. The clicker test provides an easy way to assess this ability and its performance may also reflect functioning of executive-action systems. Further studies examining whether SMF deficits predict cognitive recovery in stroke survivors more generally are needed.
Detecting subcellular dynamic behaviours with dynamic full-field OCT on stressed retinal pigment epithelium cell cultures (2021)

By inducing stress on Retinal Pigment Epithelium cell cultures, changes in dynamic subcellular signals were observed with Dynamic Full-Field OCT. Comparing with immunochemistry, mitochondria were identified as the main contributor of dynamic signal.
Video Relationship Reasoning Using Gated Spatio-Temporal Energy Graph (2019)

Visual relationship reasoning is a crucial yet challenging task for understanding rich interactions across visual concepts. For example, a relationship {man, open, door} involves a complex relation {open} between concrete entities {man, door}. While much of the existing work has studied this problem in the context of still images, understanding visual relationships in videos has received limited attention. Due to their temporal nature, videos enable us to model and reason about a more comprehensive set of visual relationships, such as those requiring multiple (temporal) observations (e.g., {man, lift up, box} vs. {man, put down, box}), as well as relationships that are often correlated through time (e.g., {woman, pay, money} followed by {woman, buy, coffee}). In this paper, we construct a Conditional Random Field on a fully-connected spatiotemporal graph that exploits the statistical dependency between relational entities spatially and temporally. We introduce a novel gated energy function parametrization that learns adaptive relations conditioned on visual observations. Our model optimization is computationally efficient, and its space computation complexity is significantly amortized through our proposed parameterization. Experimental results on benchmark video datasets (ImageNet Video and Charades) demonstrate state-of-the-art performance across three standard relationship reasoning tasks: Detection, Tagging, and Recognition.
Subject Identifiers for Security Event Tokens (2023)

Security events communicated within Security Event Tokens may support
a variety of identifiers to identify the subject and/or other
principals related to the event. This specification formalizes the
notion of subject identifiers as named sets of well-defined claims
describing the subject, a mechanism for representing subject
identifiers within a [JSON] object such as a JSON Web Token [JWT] or
Security Event Token [SET], and a registry for defining and allocating
names for these claim sets.
The Gel Matrix of Gastric Mucus Is Maintained by a Complex Interplay of Transient and Nontransient Associations (2003)

The gel nature of mucus is fundamental to its physiological functions; however, the structure of the mucus gel matrix is unclear. Here, small and large deformation rheology has been used to investigate the physical nature of the gel matrix and the forces that maintain this matrix in pig gastric mucus. The gelation process in mucus has been shown to be comparable with that of other polymer gel systems. Nongelling portions of mucin have been identified within the gel network, and the importance of transient, relaxable interactions to the maintenance of the mucus gel matrix has been demonstrated. The structure of the mucus gel matrix is considered in relation to the functional properties of mucus gels.
Fractionation of Zein by Size Exclusion Chromatography (2007)

Zein is a group of alcohol-soluble corn proteins, which consists of several individual proteins. A single-step gel filtration chromatography method was developed to fractionate individual zeins from ethanol extracts of whole corn. A Superdex prep 75 column was used with different mobile phases to fractionate the zeins, which were analyzed by SDS-PAGE and UV spectrophotometry. With 70% aqueous ethanol as the mobile phase, fractions containing a mixture of alpha-zein/beta-zein and alpha-zein/delta-zein were obtained. With ammonium bicarbonate added to the 70% ethanol mobile phase, it was possible to obtain beta-zein and delta-zein fractions devoid of other proteins. However, all fractions containing alpha-zein also contained minor amounts of delta-zein and/or beta-zein. Almost all fractions also contained non-protein impurities.
Evaluation of Interior PM and Surface PM Synchronous machines with distributed and concentrated windings (2008)

This paper presents a detailed evaluation and comparison of surface PM and interior PM synchronous machines with concentrated and distributed windings. The machines are compared based on optimal designs having the same stator OD, stack length, identical magnet volume, equal air-gap length and same peak current. The maximum open circuit voltage is also included in the trade-off analysis and machines with constrained and unconstrained maximum BEMF are considered. The study shows that for designs with equal maximum BEMF the IPM motor exhibits a much higher peak torque density than the SPM. This is because in an IPM motor the reluctance torque more than offsets the reduction in permanent magnet torque due to the reduction in q-axis current. The study also shows that, for the given set of design constraints, even if the maximum BEMF is not limited, the SPM outperforms the IPM by less than 2%. The use of concentrated windings yields a slightly higher torque density for very short stack length designs but a longer stack increases the weight.
The T‐type calcium channel antagonist, Z944, reduces spinal excitability and pain hypersensitivity (2021)

T-type calcium channels critically shape the excitability of lamina I pain processing neurons and inhibition of these channels by the clinical stage antagonist Z944 potently reverses pain hypersensitivity across sexes.
A Multi-criterial Decision Support System for Forest Management (1999)

We describe a research project that has as its goal development of a full-featured decision support system for managing forested land to satisfy multiple criteria represented as timber, wildlife, water, ecological, and wildlife objectives. The decision process proposed for what was originally conceived of as a Northeast Decision Model (NED) includes data acquisition, goal selection, goal satisfaction analysis, goal conflict analysis, stand modification recommendations, silvicultural method assignment, and stand treatment recommendations. NED-1 supports the first three functions. We discuss the AI techniques that are used in NED-1 and that will be used to add the remaining functions planned for later versions of NED.
Anti-endothelial cell antibodies from patients with thrombotic thrombocytopenic purpura specifically activate small vessel endothelial cells (2001)

Thrombotic thrombocytopenic purpura (TTP) is an uncommon disease of an unknown etiology, characterized by consumptive thrombocytopenia, microangiopathic hemolytic anemia, fever and acute thrombotic complications, especially within the cerebral circulation. Although anti-endothelial cell antibodies (AECA) have occasionally been shown to be present in TTP, their role in the pathogenesis of the disease has never been ascertained. In the current study we demonstrated the pathogenic activity of affinity-purified anti-endothelial cell F(ab)2 antibodies (AECA/TTP) from four consecutive patients with active TTP. These AECA/TTP bound to and activated only microvascular endothelial cells (EC) and not large vessel EC. The specificity of AECA/TTP binding to microvascular EC was confirmed by competition assay employing membranes derived from small and large vessels EC. Activation included enhanced IL-6 and von Willebrand factor release from the EC followed by increased expression of adhesion molecules P-selectin, E-selectin and vascular cell adhesion molecule-1 on the EC, as evaluated by ELISA. Increased expression of adhesion molecules was followed by an increase in monocyte adhesion to EC. The level of soluble thrombomodulin (TM) also increased in the culture medium of activated microvascular EC upon exposure to AECA/TTP antibodies and was directly correlated to a decrease in cell-associated TM. Our data suggest that AECA/TTP directed against microvascular EC could play a pathogenic role in the development of endothelial injury in TTP that leads to thrombosis.
T-Lymphocyte Variant of Hairy-Cell Leukemia (1978)

Immunohematologic studies on cells from a patient with the clinicopathologic syndrome of hairy-cell leukemia showed that the neoplastic cells had receptors for sheep erythrocytes and therefore had human T-lymphocyte characteristics. The leukemic cells did not have the membrane receptors or immunoglobulin markers of B lymphocytes or monocytes nor did they synthesize immunoglobulin. A lymphoid cell line established in vitro from the cells had the same T-lymphocyte characteristics. The lymphoid cell line is positive for tartrateresistant acid phosphatase, forms rosettes with untreated sheep erythrocytes, and reacts with an anti-T-lymphocyte antiserum. Thus the syndrome of hairy-cell leukemia may occasionally result from the neoplastic proliferation of T-lymphocytes as well as from the more usual B-lymphocyte form. This situation is analogous to that described previously in chronic lymphocytic leukemia and other lymphoproliferative disorders.
Pre-metal clean optimization for cluster defect prevention (2002)

Pre-metal clean is a critical procedure before the metal loop in the salicide process. Surface defects such as the surface native oxide or any other contamination may result in a poor adhesion of Ti/TiN, for example, and hence the poor salicide formation. HF treatment with IPA dry is a widely used methodology for surface defect removal, and results in a clean surface which is water spot free and has less chemical oxide. However, a cluster type defect is an accompaniment of this treatment in the salicide process. The aim of this work is to provide an optimized cleaning procedure at pre-metal clean for mass production.
Control of filtering bleb scarring trough tissue bioengineering (2008)

Abstract Purpose To evaluate the effects on intraocular pressure (IOP) reduction and bleb morphology of a new biodegradable collagen implant iGen TM, a porous matrix reducing scar formation after glaucoma surgery. Methods We conducted a prospective interventional case series in 18 eyes of 18 patients with uncontrolled primary open‐angle glaucoma. We performed limbal‐based deep‐sclerectomy with implantion of the device in the scleral bed. We performed a complete ophtalmic examination, ultrasound biomicroscopy (UBM) and Visante anterior segment Optical Coherence Tomography (OCT) at each follow up visit, scheduled 1 day, 1 week, 4 and 12 weeks post‐operatively. Results Postoperative IOP decreased significantly (p &lt; 0.001) from a preoperative mean value of 25.1 ± 5.9 mm Hg (n = 2.73 glaucoma medications) to a postoperative mean value of 8.0 ± 1.1 (n = 0), 8.3 ± 1.2 (n = 0), 11.5 ± 3.0 (n = 0) and 14.1 ± 3.7 mm Hg (n = 0.28) at 1 day, 1week, 4 and 12 weeks respectively. Characteristic imaging parameters of successful bleb were frequently observed (14/18 patients): high and hypoechoic bleb with UBM; thin and hyporeflective bleb wall, multiple subconjunctival fluid spaces and hyporeflective deep bleb tissue with OCT. Bleb height and trabeculocorneal membrane thickness are correlated with low IOP (r = 0.91 p &lt; 0.01, r = 0.90 p &lt; 0.001) with UBM examination. Thin bleb wall, large subconjunctival fluid spaces and low reflectivity of bleb tissue are associated with lower IOP (r = 0.81 p &lt; 0.01, p &lt; 0.001 and p &lt; 0.001) with OCT examination. No post‐operative complications were reported. Conclusion In our series, deep‐sclerectomy with iGen TM implantation seems to be an effective and well‐tolerated method to lower IOP and avoid conjunctival scarring.
Accelerated Deactivation of Hydrotreating Catalysts by Coke Deposition (2011)

Pilot plant experiments are designed to allow for evaluation of the impact caused by increasing the severity of key operation variables on deactivation of hydrotreating (HDT) catalysts, through accelerated runs performed in short periods of time. One of the main aspects of this work is the use of a kinetic approach in order to observe the impact of accelerated deactivation conditions upon catalyst performances during hydrodesulfurization (HDS), hydrodenitrogenation (HDN), and aromatic hydrogenation (HDA) reactions. This approach allows for evaluation of catalyst deactivation for each of the analyzed reactions. Results obtained with a reference catalyst indicate that the proposed methodology is able to deactivate the catalyst effectively, leading to proper representation of actual industrial deactivation at the end of a catalyst life cycle.
Confidence Estimation of ToF and Stereo Data for 3D Data Fusion. Stima della Confidenza delle Misure Ottenute da Sensori ToF e da Sistemi Stereo per la Fusione di Dati 3D (2013)

This thesis focuses on the analysis of ToF and stereo vision systems, with the goal of extracting reliable confidence measures associated to the computed depth maps.The two families of sensors are described and after an analysis on practical issues some confidence measures are provided.Then, a framework for 3D data fusion with confidence information is presented and evaluated over a dataset of real world data.Results show that the proposed approach outperforms the performance of the two systems
Crystal Structure of RSV strain B18537 Prefusion-stabilized glycoprotein F Variant DS-Cav1 (2019)

We propose that structural differences in apical and equatorial sites-coupled to differently focused immune responses-provide a molecular explanation for observed differences in elicited subtype A and B neutralizing responses.
3D perfusion mapping in the intact mouse heart after myocardial infarction using myocardial contrast echocardiography (2005)

An intact mouse model of surgically-induced myocardial infarction (MI) caused by permanent occlusion of the Left Anterior Descending (LAD) coronary artery was studied. Normal mice with no occlusion were also studied as controls. For each mouse, contrast enhanced ultrasound images of the heart were acquired in parallel cross-sections perpendicular to the sternum at millimeter increments. For accurate 3D reconstruction, ECG gating and a tri-axial adjustable micromanipulator were used for temporal and spatial registration. Ultrasound images at steady-state of blood refilling were color-coded in each slice to show relative perfusion. Myocardial perfusion defects and necrosis were also examined postmortem by staining with Phthalo blue and TTC red dyes. Good correlation (R>0.93) in perfused area size was observed between in vivo measurements and histological staining. A 3D multi-slice model and a 3D rendering of perfusion distribution were created and showed a promising match with postmortem results, lending further credence to its use as a more comprehensive and more reliable tool for in vivo assessment of myocardial perfusion than 2D tomographic analysis.