gebhart/patrepeval huggingface dataset:
Using Robus In Electrical And Computer Engineering Education (2024)

Abstract NOTE: The first page of text has been automatically extracted and included below in lieu of an abstract Session 2220 Using ROBUS in Electrical and Computer Engineering Education François Michaud, Mario Lucas, Gérard Lachiver, André Clavet, Jean-Marie Dirand, Noël Boutin, Philippe Mabilleau, Jacques Descôteaux Université de Sherbrooke (Québec Canada) Abstract ROBUS (ROBot University of Sherbrooke) is an autonomous mobile robot designed to facilitate interdisciplinary engineering design in Electrical Engineering (EE) and Computer Engineering (CE). Its primary purpose is to serve as an integrated platform for a project called INGÉNIUS that introduces electrical and computer engineering simultaneously to a large group of first-year undergraduate students registered in these two distinct programs. Divided in thirty-five teams of six or seven, these students are being initiated to various aspects of electrical and computer engineering such as electric circuits, electronics, sensors and actuators, logic circuits and CPLD, microprocessors, real-time C programming, robotics, technical drawing and communication. This way, ROBUS gives hands-on technical and teamwork experiences early in the curriculum. The robot is used in six different courses, and an interdisciplinary team of professors also work together to coordinate these activities. At the end of the second semester, teams participate in a robot competition where the objective is to design an entertainment robot for children with learning disorders. For fourth-year students in EE and CE, ROBUS is used in more advanced undergraduate courses such as Microprocessor Interfaces, Real-Time Systems, Robotics Projects and also in one graduate course on Artificial Intelligence. The projects done in these courses are oriented toward giving more advanced capabilities to ROBUS, help developed complete autonomous robots and to teach specific concepts. This paper gives a description of ROBUS and how it is used in these activities. I. Introduction The Department of Electrical and Computer Engineering at the Université de Sherbrooke offers two distinct bachelor engineering degrees, one in Electrical Engineering and one in Computer Engineering (which has been initiated six years ago). Even though both programs share some activities and that students are placed in an environment that involves electrical and software considerations, students are still having difficulties integrating and applying the engineering knowledge and skills that they learn. To avoid this problem, we thought that more could be done to develop this ability early in the curricula. We also wanted to put students in situations closer to the reality of the profession by making them work on projects that involve multidisciplinary considerations, design and analysis abilities, autonomous learning, teamwork and communication skills.
High-Yielding Aqueous 18F-Labeling of Peptides via Al18F Chelation (2011)

The coordination chemistry of a new pentadentate bifunctional chelator (BFC), NODA-MPAA 1, containing the 1,4,7-triazacyclononane-1,4-diacetate (NODA) motif with a methylphenylacetic acid (MPAA) backbone, and its ability to form stable Al(18)F chelates were investigated. The organofluoroaluminates were easily accessible from the reaction of 1 and AlF(3). X-ray diffraction studies revealed aluminum at the center of a slightly distorted octahedron, with fluorine occupying one of the axial positions. The tert-butyl protected prochelator 7, which can be synthesized in one step, is useful for coupling to biomolecules on solid phase or in solution. High yield (55-89%) aqueous (18)F-labeling was achieved in 10-15 min with a tumor-targeting peptide 4 covalently linked to 1. Defluorination was not observed for at least 4 h in human serum at 37 °C. These results demonstrate the facile application of Al(18)F chelation using BFC 1 as a versatile labeling method for radiofluorinating other heat-stable peptides for positron emission imaging.
Coadministration of Telomerase Genetic Vaccine and a Novel TLR9 Agonist in Nonhuman Primates (2009)

The human telomerase reverse transcriptase (hTERT) is an attractive target for human cancer vaccination because its expression is reactivated in most human tumors. We have evaluated the ability of DNA electroporation (DNA-EP) and adenovirus serotype 6 (Ad6) to induce immune responses against hTERT in nonhuman primates (NHPs) (Macaca mulatta). Vaccination was effective in all treated animals, and the adaptive immune response remained detectable and long lasting without side effects. To further enhance the efficacy of the hTERT vaccine, we evaluated the combination of hTERT vaccine and a novel TLR9 agonist, referred to as immunomodulatory oligonucleotide (IMO). Monkeys were dosed weekly with IMO concurrently with the vaccine regimen and showed increases in cytokine secretion and activation of natural killer (NK) cells compared with the group that received vaccine alone. Using a peptide array, a specific profile of B-cell reactive epitopes was identified when hTERT vaccine was combined with IMO. The combination of IMO with hTERT genetic vaccine did not impact vaccine-induced TERT-specific cell-mediated immunity. Our results show that appropriate combination of a DNA-EP/Ad6-based cancer vaccine against hTERT with IMO induces multiple effects on innate and adaptive immune responses in NHPs.
ChemInform Abstract: Synthesis of New Perfluoroalkylamino Acid Derivatives of Lysine, Arginine, and Cysteine. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplemental Figure 1 from A Phase I Trial of a Guadecitabine (SGI-110) and Irinotecan in Metastatic Colorectal Cancer Patients Previously Exposed to Irinotecan (2023)

&lt;p&gt;LINE1 changes in circulating DNA CpG 1-3 as compared to baseline.&lt;/p&gt;
Thoracoscopic Scoliosis Surgery Affects Pulmonary Function Less Than Thoracotomy at 2 Years Postsurgery (2007)

This study shows a clear advantage to the minimally invasive thoracoscopic approach with regards to pulmonary function when compared with the open thoracotomy approaches.
Coplanar Recognition by a Rebek Cleft Is Provided by Cooperative Structural Effects Involving a Combination of O−H···O, O−H···N, and C−H···O Forces (2001)

Reaction of 2,7-di-tert-butyl-9,9-dimethyl-4,5-xanthenedicarboxylic acid (1), a Rebek cleft, with 1,2-trans-bis(2-pyridyl)ethylene (2) yields a three-component organic assembly, 2(1).2 (3), of nanoscale dimensions that is held together by 10 cooperative O-H.N, O-H.O, and C-H.O hydrogen bonds. The cleft adopts a planar conformation, by forming an intramolecular O-H.O hydrogen bond, which enables the host to recognize the guest in a coplanar orientation that facilitates the cooperativity displayed by the multiple forces.
Magnetorheological finishing: new fluids for new materials (2000)

The three primary ingredients in a magnetorheological fluid are the magnetic carbonyl iron particles, the abrasive polishing powder, and the carrier fluid. Systematic variations in all three allow magnetorheological finishing to be successfully used in the production of precision optics from water soluble crystals, optical glasses, or extremely hard glass-ceramics.
Neurotoxicity of ammonia and glutamate: molecular mechanisms and prevention. (1998)

Ammonia is a main factor in the pathogenesis of hepatic encephalopathy. We found that acute ammonia toxicity is mediated by activation of NMDA receptors. Chronic moderate hyperammonemia prevents acute ammonia toxicity in rats. Chronic exposure of cultured neurons to 1 mM ammonia leads to impaired response of the NMDA receptor to activation by its agonists (due to decreased protein kinase C-mediated phosphorylation) and prevents glutamate (Glu) neurotoxicity. Compounds that prevent ammonia toxicity in mice (e.g. carnitine) also prevent Glu toxicity in cultured neurons. These compounds did not prevent activation of NMDA receptor or the rise of Ca2+. They interfered with subsequent steps in the toxic process. The protective effect of carnitine is mediated by activation of metabotropic Glu receptors. Agonists of mGluRs, especially of mGluR5, prevent Glu toxicity. Agonists of muscarinic receptors also prevent Glu toxicity and there seems to be an interplay between muscarinic and metabotropic Glu receptors in the protective effect. We have tried to identify intracellular events involved in the process of neuronal death. It is known that the rise of Ca2+ is an essential step. Glu leads to depletion of ATP; some compounds (e.g. carnitine) prevent Glu-induced neuronal death without preventing ATP depletion: additional events are required for neuronal death. Glu induces activation of Na+/K+-ATPase, which could be involved in the toxic process. Inhibitors of protein kinase C, calcineurin or nitric oxide synthase prevent Glu toxicity. Our results indicate that Glu toxicity can be prevented at different steps or by activating receptors coupled to the transduction pathways interfering with the toxic process. Agents acting on these steps could prevent excitotoxicity in vivo in animals.
The Effects of Tonic Locus Ceruleus Output on Sensory-Evoked Responses of Ventral Posterior Medial Thalamic and Barrel Field Cortical Neurons in the Awake Rat (2004)

In mammals, the pontine nucleus locus ceruleus (LC) is the sole source of norepinephrine (NE) projections to the forebrain. Increasing tonic discharge of LC neurons elevates extracellular levels of NE in the cortex and thalamus. Tonic LC discharge is linked to the level of wakefulness and behavioral performance, demonstrating an optimal firing rate during sustained attention tasks. Iontophoretic application of NE to target neurons in the forebrain has been shown to produce a diverse set of neuromodulatory actions, including augmentation of synaptically evoked discharge as well as suppression of spontaneous and stimulus-evoked firing patterns. Iontophoretic studies cataloged potential NE effects; however, the context in which such actions could occur in awake behaving animals remained controversial. To address this issue, the current study examined the effects of increasing tonic LC output on spontaneous and stimulus-evoked discharge of neurons within the ventroposterior medial (VPM) thalamus and barrel field (BF) somatosensory cortex of awake animals using multichannel extracellular recording strategies. The present findings indicate two primary outcomes that result from increasing frequencies of LC stimulation, either an inverted-U facilitating response profile or monotonic suppression of sensory-evoked neuronal responses. Increased tonic LC output generally decreased neuronal response latency measures for both BF cortical and VPM thalamic cells. LC-mediated effects on target VPM and BF cortical neuron sensory processing are consistent with previous demonstrations of NE modulatory actions on central neurons but indicate that such actions are cell specific. Moreover, clear differences were observed between the modulation of VPM and BF cortical cells. These data suggest that sensory signal processing is continually altered over the range of tonic LC discharge frequencies that occur in the waking animal. Such changes may account for LC-mediated shifts in sensory network performance across multiple stages of arousal and attention.
Paramagnetic Liposomes as Magnetic Resonance Contrast Agents (1990)

UNGER, EVAN MD; TILCOCK, COLIN PHD; AHKONG, QUET FAH PHD; FRITZ, THOMAS MSC Author Information
A fifty-year odyssey: prospects for a cytomegalovirus vaccine in transplant and congenital infection (2018)

There is a concerted effort to unify separate therapeutic and prophylactic vaccine strategies into a single delivery agent that would be effective for both transplant-related and congenital infection.
Digital system to monitor the natural frequency of mechanical resonators (2013)

Mechanical resonators are often used in process or condition monitoring. They are used for liquid-level limit detection or for viscosity and density sensing. Therefore, the resonator is preferably actuated at its natural frequency. In industrial applications, this is achieved by analogue closed resonant circuits. These circuits have been established because of the low energy consumption and low component costs. Due to the future trend of microprocessors, digital systems are now an interesting alternative and can achieve better results compared to analogue realizations. In this context, this paper presents a novel digital system for monitoring the natural frequency of mechanical resonators. The system is realized with newly developed algorithms and is based on a simple signal processing procedure with minimum computational cost. This allows the use of a low-power microcontroller, thus making the system interesting for industrial use. It is shown that the natural frequency can be measured in respect of high industrial requirements on reliability, fastness and accuracy, combined with the possibility of reducing energy consumption.
Molecular Mechanisms of Serum Resistance of Human Influenza H3N2 Virus and Their Involvement in Virus Adaptation in a New Host (1998)

H3N2 human influenza viruses that are resistant to horse, pig, or rabbit serum possess unique amino acid mutations in their hemagglutinin (HA) protein. To determine the molecular mechanisms of this resistance, we characterized the receptor-binding properties of these mutants by measuring their affinity for total serum protein inhibitors and for soluble receptor analogs. Pig serum-resistant variants displayed a markedly decreased affinity for total pig serum sialylglycoproteins (which contain predominantly 2-6 linkage between sialic acid and galactose residues) and for the sialyloligosaccharide 6'-sialyl(N-acetyllactosamine). These properties correlated with the substitution 186S-->I in HA1. The major inhibitory activity in rabbit serum was found to be a beta inhibitor with characteristics of mannose-binding lectins. Rabbit serum-resistant variants exhibited decreased sensitivity to this inhibitor due to the loss of a glycosylation sequon at positions 246 to 248 of the HA. In addition to a somewhat reduced affinity for 6'-sialyl(N-acetyllactosamine)-containing receptors, horse serum-resistant variants lost the ability to bind the viral neuraminidase-resistant 4-O-acetylated sialic acid moieties of equine alpha2-macroglobulin because of the mutation 145N-->K/D in their HA1. These results indicate that influenza viruses become resistant to serum inhibitors because their affinity for these inhibitors is reduced. To determine whether natural inhibitors play a role in viral evolution during interspecies transmission, we compared the receptor-binding properties of H3N8 avian and equine viruses, including two strains isolated during the 1989 to 1990 equine influenza outbreak, which was caused by an avian virus in China. Avian strains bound 4-O-acetylated sialic acid residues of equine alpha2-macroglobulin, whereas equine strains did not. The earliest avian-like isolate from a horse influenza outbreak bound to this sialic acid with an affinity similar to that of avian viruses; a later isolate, however, displayed binding properties more similar to those of classical equine strains. These data suggest that the neuraminidase-resistant sialylglycoconjugates present in horses exert selective pressure on the receptor-binding properties of avian virus HA after its introduction into this host.
Plasminogen activators, their inhibitors, and urokinase receptor emerge in late stages of melanocytic tumor progression. (1994)

Degradation of the extracellular matrix and other tissue barriers by proteases like plasminogen activators (PAs) is a prerequisite for neoplastic growth and metastasis. Recently, we reported that highly metastatic behavior of human melanoma cells in nude mice correlates with urokinase-type PA (u-PA) expression and activity and with PA inhibitor type 1 and 2 (PAI-1, PAI-2) expression. Here we report on the occurrence of components of the PA system in the various stages of human melanoma tumor progression in situ. We studied the protein distribution on freshly frozen lesions of common nevocellular nevi (n = 25), dysplastic (= atypical) nevi (n = 16), early primary melanomas (n = 8), advanced primary melanomas (n = 11), and melanoma metastases (n = 17). Tissue-type PA was present in endothelial cells in all lesions, whereas in metastases it could be detected in tumor cells in a minority of the lesions. u-PA, its receptor, PAI-1, and PAI-2 could not be detected in benign and in early stages but appeared frequently in advanced primary melanoma and melanoma metastasis lesions. u-PA was detected in stromal cells and in tumor cells at the invasive front, the u-PA receptor and PAI-2 in tumor cells, and PAI-1 in the extracellular matrix surrounding tumor cells. Localization of the corresponding messenger RNAs and enzyme activities revealed a similar distribution. We conclude that plasminogen activation is a late event in melanoma tumor progression.
Neuronal Release of Cytokine IL-3 Triggered by Mechanosensitive Autostimulation of the P2X7 Receptor Is Neuroprotective (2016)

Mechanical strain due to increased pressure or swelling activates inflammatory responses in many neural systems. As cytokines and chemokine messengers lead to both pro-inflammatory and neuroprotective actions, understanding the signaling patterns triggered by mechanical stress may help improve overall outcomes. While cytokine signaling in neural systems is often associated with glial cells like astrocytes and microglia, the contribution of neurons themselves to the cytokine response is underappreciated and has bearing on any balanced response. Mechanical stretch of isolated neurons was previously shown to trigger ATP release through pannexin hemichannels and autostimulation of P2X7 receptors (P2X7Rs) on the neural membrane. Given that P2X7Rs are linked to cytokine activation in other cells, this study investigates the link between neuronal stretch and cytokine release through a P2X7-dependent pathway. Cytokine assays showed application of a 4% strain to isolated rat retinal ganglion cells (RGCs) released multiple cytokines. The P2X7R agonist BzATP also released multiple cytokines; Interleukin 3 (IL-3), TNF-α, CXCL9, VEGF, L-selectin, IL-4, GM-CSF, IL-10, IL-1Rα, MIP and CCL20 were released by both stimuli, with the release of IL-3 greatest with either stimuli. Stretch-dependent IL-3 release was confirmed with ELISA and blocked by P2X7R antagonists A438079 and Brilliant Blue G (BBG), implicating autostimulation of the P2X7R in stretch-dependent IL-3 release. Neuronal IL-3 release triggered by BzATP required extracellular calcium. The IL-3Rα receptor was expressed on RGCs but not astrocytes, and both IL-3Rα and IL-3 itself were predominantly expressed in the retinal ganglion cell layer of adult retinal sections, implying autostimulation of receptors by released IL-3. While the number of surviving ganglion cells decreased with time in culture, the addition of IL-3 protected against this loss of neurons. Expression of mRNA for <i>IL-3</i> and <i>IL-3Rα</i> increased in rat retinas stretched with moderate intraocular pressure (IOP) elevation; BBG blocked the rise in <i>IL-3</i>, implicating a role for the P2X7R in transcriptional regulation <i>in vivo</i>. In summary, mechanical stretch triggers release of cytokines from neurons that can convey neuroprotection. The enhancement of these signals <i>in vivo</i> implicates P2X7R-mediated IL-3 signaling as an endogenous pathway that could minimize damage following neuronal exposure to chronic mechanical strain.
Experimental Study of Micro‐Scale Taylor Vortices Within a Co‐Axial Mixed‐Flow Blood Pump (2015)

Taylor vortices in a miniature mixed-flow rotodynamic blood pump were investigated using micro-scale particle image velocimetry (μ-PIV) and a tracer particle visualization technique. The pump featured a cylindrical rotor (14.9 mm diameter) within a cylindrical bore, having a radial clearance of 500 μm and operated at rotational speeds varying from 1000 to 12 000 rpm. Corresponding Taylor numbers were 700-101 800, respectively. The critical Taylor number was observed to be highly dependent on the ratio of axial to circumferential velocity, increasing from 1200 to 18 000 corresponding to Rossby numbers from 0 to 0.175. This demonstrated a dramatic stabilizing effect of the axial flow. The size of Taylor vortices was also found to be inversely related to Rossby number. It is concluded that Taylor vortices can enhance the mixing in the annular gap and decrease the dwell time of blood cells in the high-shear-rate region, which has the potential to decrease hemolysis and platelet activation within the blood pump.
Mean Field Approach for Configuring Population Dynamics on a Biohybrid\n Neuromorphic System (2019)

Real-time coupling of cell cultures to neuromorphic circuits necessitates a\nneuromorphic network that replicates biological behaviour both on a per-neuron\nand on a population basis, with a network size comparable to the culture. We\npresent a large neuromorphic system composed of 9 chips, with overall 2880\nneurons and 144M conductance-based synapses. As they are realized in a robust\nswitched-capacitor fashion, individual neurons and synapses can be configured\nto replicate with high fidelity a wide range of biologically realistic\nbehaviour. In contrast to other exploration/heuristics-based approaches, we\nemploy a theory-guided mesoscopic approach to configure the overall network to\na range of bursting behaviours, thus replicating the statistics of our targeted\nin-vitro network. The mesoscopic approach has implications beyond our proposed\nbiohybrid, as it allows a targeted exploration of the behavioural space, which\nis a non-trivial task especially in large, recurrent networks.\n
Vibronic structure in the emission spectrum of the tetranuclear copper cluster [Cu4]4(dmpp)4] (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVibronic structure in the emission spectrum of the tetranuclear copper cluster [Cu4]4(dmpp)4]Dorothy C. Lai and Jeffrey I. ZinkCite this: Inorg. Chem. 1993, 32, 11, 2594–2596Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/ic00063a064https://doi.org/10.1021/ic00063a064research-articleACS PublicationsRequest reuse permissionsArticle Views244Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts