gebhart/patrepeval huggingface dataset:
376: Internet-Based Multi-Institutional Clinical Research: A Convenient and Secure Option (2004)

You have accessJournal of UrologyDiscussed Poster, Sunday, May 9, 2004, 8:00 am - 12:00 pm1 Apr 2004376: Internet-Based Multi-Institutional Clinical Research: A Convenient and Secure Option Brian K. Auge, Paul K. Pietrow, and Glenn M. Preminger Brian K. AugeBrian K. Auge More articles by this author , Paul K. PietrowPaul K. Pietrow More articles by this author , and Glenn M. PremingerGlenn M. Preminger More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)37638-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "376: Internet-Based Multi-Institutional Clinical Research: A Convenient and Secure Option." The Journal of Urology, 171(4S), p. 99 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 99 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Brian K. Auge More articles by this author Paul K. Pietrow More articles by this author Glenn M. Preminger More articles by this author Expand All Advertisement PDF downloadLoading ...
3D Scene Manipulation with 2D Devices and Constraints (2001)

Content creation for computer graphics applications is a laborious process that requires skilled personnel. One fundamental problem is that manipulation of 3D objects with 2D user interfaces is very difficult for non-experienced users. In this paper, we introduce a new system that uses constraints to restrict object motion in a 3D scene, making interaction much simpler and more intuitive. We compare three different 3D scene manipulation techniques based on a 2D user interface. We show that the presented techniques are significantly more efficient than commonly used solutions. To our knowledge, this is the first evaluation of 3D manipulation techniques with 2D devices and constraints.
Volume–outcome relationship of liver surgery: a nationwide analysis (2020)

Hospital volume and postoperative outcomes were not associated.
Synthesis and Photodynamics of 9-Mesitylacridinium Ion-Modified Gold Nanoclusters (2010)

Photoexcitation of gold nanoclusters covalently functionalized with 9-mesityl-10-methylacridinium ion (Mes-Acr(+)) resulted in the formation of the electron-transfer state (Mes(*+)-Acr(*)), which forms a pi-dimer radical cation with the neighboring Mes-Acr(+) via an intramolecular pi-pi interaction.
Implementation strategy fidelity evaluation for a multidisciplinary Chest Injury Protocol (ChIP) (2021)

Trial registered on ANZCTR. Registration number ACTRN12618001548224 , date approved 17/09/2018.
Real World Data on the Utilization Pattern and Safety Profile of Infliximab Originator Versus Biosimilars in Italy: A Multiregional Study (2018)

Our study demonstrates that, along with a rapid increase in the utilization of infliximab biosimilars across Italy, there was also an increase in reporting ADRs induced by infliximab biosimilars. Of the reported ADRs, 7.4% were considered preventable. In adjusted analyses, infliximab biosimilars were shown to have an increased probability of being reported as suspected drugs in infusion reactions and a decreased probability of being reported as suspected drugs in cases of lack of efficacy or infection. Considering the potential advantages offered by the utilization of biosimilars in clinical practice, we believe that the use of biosimilars, including those of infliximab, should be supported. In order to achieve this aim, increased knowledge on safety and efficacy of biosimilar drugs should be obtained from real world clinical practice.
Towards Overlay-based Rapid In-Circuit Tuning of Deep Learning Designs (2020)

This paper presents a novel overlay-based approach for rapid in-circuit debugging and tuning of Deep Learning (DL) designs targeting Field-Programmable Gate Array (FPGA). We first propose overlay-based instruments designed to provide profiling information of hardware to builders of deep learning applications for tuning and debugging FPGA designs. Our instrumentation is optimized to take advantage of characteristics of DL application domain-specific information. We also implement a light-weight overlay-based Deep Neural Networks (DNN) processing engine that supports rapid word length tuning for each DNN layer's datapath without requiring time-consuming compilation of FPGA designs multiple times. Combining the overlay-based instrument and DNN processing engine together, we can visualize the patterns of overflow exceptions and support rapid mixed precision tuning of DNN layers on FPGAs.
The Capacity of Memoryless Channels with Sampled Cyclostationary\n Gaussian Noise (2019)

Non-orthogonal communications play an important role in future communication\narchitectures. In such scenarios, the received signal is corrupted by an\ninterfering signal which is typically cyclostationary in continuous-time. If\nthe period of interference is synchronized with the sampling period, the\nsampled interference is a discrete-time (DT) cyclostationary process. However,\nin the common interference scenario, the period of the interference is not\nnecessarily synchronized with the sampling period. In such cases, the DT\ninterference is an almost cyclostationary process. In this work we characterize\nthe capacity of channels in which the noise arises from a sampled\ncyclostationary Gaussian process. For the case of synchronous sampling,\ncapacity can be obtained in closed form. When sampling is not synchronized with\nthe symbol rate of the interference, the resulting channel is not information\nstable, thus classic tools are not applicable. Using information spectrum\nmethods, we prove that capacity can be obtained as the limit of a sequence of\ncapacities of channels with cyclostationary noise. Our results characterize the\neffects of changes in the sampling rate and sampling time offset on the\ncapacity of the resulting DT channel. In particular, we demonstrate that minor\nvariations in the sampling period can substantially affect capacity.\n
Endocannabinoid system acts as a regulator of immune homeostasis in the gut (2017)

Significance Exogenous cannabinoids such as marijuana exert their influence through cannabinoid receptors. Endogenous cannabinoids such as anandamide (AEA) function through the same receptors, and their physiological roles are a subject of intense study. Here, we show that AEA plays a pivotal role in maintaining immunological health in the gut. The immune system in the gut actively tolerates the foreign antigens present in the gut through mechanisms that are only partially understood. We show that AEA contributes to this critical process by promoting the presence of CX3CR1 hi macrophages, which are immunosuppressive. These results uncover a major conversation between the immune and nervous systems. In addition, with the increasing prevalence of ingestion of exogenous marijuana, our study has significant implications for public health.
A new parameter estimation for K distribution clutter (2008)

K distribution is one of the most widely applied statistical models for SAR images clutter. Now there are several approaches to estimate the parameters of K distribution. Based on Raghavan’s method, a new method named piecewise-approximation is given in this paper, where Gamma and Beta-Prime distributions are applied to piecewisely approximate K distribution. The experiment results show that the new method broadens the applicable range of parameter, and has a higher accuracy than the method of moment.
Copper-Treated Philippine Natural Zeolites for <i>Escherichia coli</i> Inactivation (2017)

We report the modification of Philippine natural zeolites by copper doping and its use in E. coli inactivation. Zeolite samples soaked in 25 wt. % Cu showed 40 mg/g uptake after 24 h. The samples were calcined at 400, 600, and 800°C for 2 h in order to prevent leaching of copper and increase its effectivity. The antibacterial efficiency was tested against E. coli by dilution of the sample in the suspension. Samples calcined at 400 and 600°C showed bacterial inhibition even at a very low concentration of 3 ppb while the sample calcined at 800°C showed no antibacterial inhibition.
<title>Quantitative Flow Estimation With Transcutaneous Doppler Ultrasound</title> (1979)

During the last 20 years, Doppler ultrasound has become widely accepted as a means for qualitative or semi-quantitative assessment of blood-flow patterns. Application to transcutaneous quantitation of volume flow (in milliliters/sec), however, has proved difficult. Generally, it has been assumed that the angle between the vessel axis and ultrasound beam must be determined precisely through imaging or triangulation. In addition, because volume flow is a product of velocity and area, the true area of the vessel lumen has been assumed to be essential to volume flow estimation. It has also been considered necessary to measure the velocity profile across the lumen on a point-by-point basis. A new approach to volume-flow measurement is being developed to avoid these problems, wherein flow is measured perpendicular to an arbitrary tomographic plane. The area of the lumen (as projected onto the measurement plane) and the area-average velocity of the fluid per-pendicular to this plane are the only two characteristics relevant to the estimation of volume flow. The product of these two quantities is, by definition, volume flow. As a result, precise measurements of vessel orientation and true diameter and details of the velocity profile are not required.
3D high-definition wide field-of-view optical coherence microscopy advancing real-time in-vivo cellular imaging (2016)

In-vivo imaging requires micron-scale resolution in 3D, ~1 mm depth of imaging and large field-of-view (≥1 mm). Optical coherence microscopy breaks the cellular lateral resolution limit of optical coherence tomography, enabling advances in biotech.
Optimizing glenoid bone preservation in reverse total shoulder arthroplasty using augmented baseplates (2022)

rTSA with augmented baseplates for glenoid bone preservation in patients with minimal or no bone loss is effective for preserving glenoid bone stock and significantly improves the range of motion and patient-reported outcomes after approximately 2 years.
Reverse Remodeling of the Left Cardiac Chambers After Catheter Ablation After 1 Year in a Series of Patients With Isolated Atrial Fibrillation (2005)

This study demonstrates reverse morphological remodeling of the LA and improvement of LV diastolic and systolic functions after restoration of sinus rhythm by ablation for isolated AF. Because patients with isolated AF have none of the traditional causes of LV diastolic dysfunction, our findings suggest that AF may be partly the cause rather than the consequence of diastolic dysfunction.
The Chemistry of Metallacyclic Alkenylcarbene Complexes, 8 Chelated Allyl‐Ironcarbene Complexes with a Centrally Tethered π‐Ligand‐Synthesis and Reactions with Nucleophiles (1997)

Abstract The title complexes 8 and 9 are easily prepared in two or three steps from iron carbonyls and isobutene diol 5 by Meerwein alkylation of the intermediate acyl complexes 6 and 7 . With carbon and heteroatom nucleophiles like enolates and triphenylphosphane they form either stable 4 ‐substituted alkene‐carbene complexes 10 and 11 , or substituted trimethylenemethane tricarbonyliron complexes like 12 . Oxidation with H 2 O 2 /NaOH both of the alkene‐carbene complexes 11 and of the less stable β‐oxo‐substituted trimethylene‐methane complexes 13 , as obtained from reaction of 8 with lithium enolates, yields the corresponding substituted allyl carbamates 15 or the allyl alcohols 14 , which are formally bis‐ and monosubstituted derivatives, respectively, of the starting isobutene diol.
Shedding Physical Synthesis Area Bloat (2011)

Area bloat in physical synthesis not only increases power dissipation, but also creates congestion problems, forces designers to enlarge the die area, rerun the whole design flow, and postpone the design deadline. As a result, it is vital for physical synthesis tools to achieve timing closure and low power consumption with intelligent area control. The major sources of area increase in a typical physical synthesis flow are from buffer insertion and gate sizing, both of which have been discussed extensively in the last two decades, where the main focus is individual optimized algorithm. However, building a practical physical synthesis flow with buffering and gate sizing to achieve the best timing/area/runtime is rarely discussed in any previous literatures. In this paper, we present two simple yet efficient buffering and gate sizing techniques and achieve a physical synthesis flow with much smaller area bloat. Compared to a traditional timing-driven flow, our work achieves 12% logic area growth reduction, 5.8% total area reduction, 10.1% wirelength reduction, and 770 ps worst slack improvement on average on 20 industrial designs in 65 nm and 45 nm.
Segmentation of Both Diseased and Healthy Skin From Clinical Photographs in a Primary Care Setting (2018)

This work presents the first segmentation study of both diseased and healthy skin in standard camera photographs from a clinical environment. Challenges arise from varied lighting conditions, skin types, backgrounds, and pathological states. For study, 400 clinical photographs (with skin segmentation masks) representing various pathological states of skin are retrospectively collected from a primary care network. 100 images are used for training and fine-tuning, and 300 are used for evaluation. This distribution between training and test partitions is chosen to reflect the difficulty in amassing large quantities of labeled data in this domain. A deep learning approach is used, and 3 public segmentation datasets of healthy skin are collected to study the potential benefits of pretraining. Two variants of U-Net are evaluated: U-Net and Dense Residual U-Net. We find that Dense Residual U-Nets have a 7.8% improvement in Jaccard, compared to classical U-Net architectures (0.55 vs. 0.51 Jaccard), for direct transfer, where fine-tuning data is not utilized. However, U-Net outperforms Dense Residual U-Net for both direct training (0.83 vs. 0.80) and fine-tuning (0.89 vs. 0.88). The stark performance improvement with fine-tuning compared to direct transfer and direct training emphasizes both the need for adequate representative data of diseased skin, and the utility of other publicly available data sources for this task.
Dynamics of Main Chain Liquid Crystalline Polysiloxanes Containing $p$-Phenyleneterephthalate Mesogens (2010)

The dynamics of three main-chain liquid crystalline polysiloxanes were investigated using broadband dielectric relaxation spectroscopy. The liquid crystalline polymers (LCP) differ regarding the substituents on the rigid mesogens, and the nature of the substituents is found to influence the relaxation behavior. Within the temperature and frequency range examined, five relaxations are observed; two glassy state processes are associated with motions of the spacer segments (γ relaxation) and the substituted phenyl rings (β relaxation). The segmental (α) relaxation time changes with the nature of the mesogen substituent. A relaxation assigned to interfacial polarization between domain boundaries was observed, which disappears at the LCPs clearing temperature.
Single Active Switch Power Electronics for Kilowatt Scale Capacitive Power Transfer (2014)

The development of capacitive power transfer (CPT) as a competitive wireless/contactless power transfer solution over short distances is proving viable in both consumer and industrial electronic products/systems. The CPT is usually applied in low-power applications, due to small coupling capacitance. Recent research has increased the coupling capacitance from the pF to the nF scale, enabling extension of CPT to kilowatt power level applications. This paper addresses the need of efficient power electronics suitable for CPT at higher power levels, while remaining cost effective. Therefore, to reduce the cost and losses single-switch-single-diode topologies are investigated. Four single active switch CPT topologies based on the canonical Ćuk, SEPIC, Zeta, and Buck-boost converters are proposed and investigated. Performance tradeoffs within the context of a CPT system are presented and corroborated with experimental results. A prototype single active switch converter demonstrates 1-kW power transfer at a frequency of 200 kHz with >90% efficiency.
ORGANICITY AND MENTAL RETARDATION: ANALYSIS OF EYE AND HEAD MOVEMENTS (1981)

Eye and head movements of ten mentally retarded (MR) children and ten normal school children were recorded. Each was directed to look to one side or the other in response to verbal commands, to gestural directions, or to the appearance of illuminated fixation targets. Under these conditions: 1. Large gaze movements of MR subjects were accompanied by head movements more frequently than those of the normal subjects. Furthermore, for similar gaze deviations, head movement of MR subjects tended to be larger than those of normal subjects. 2. Head movements of normal subjects rarely began before eye movement, but those of MR subjects often did so. This "abnormal" MR eye-head movement pattern was more frequent in response to verbal or gestural commands than in response elicited by illumination of fixation targets.
Development of a real-time radiological area monitoring network for emergency response at Lawrence Livermore National Laboratory (2005)

A real-time radiological sensor network for emergency response was developed and deployed at the Lawrence Livermore National Laboratory (LLNL). The real-time radiological area monitoring (RTRAM) network comprises 16 Geiger-Mueller sensors positioned on the LLNL Livermore site perimeter to continuously monitor for a radiological condition resulting from a terrorist threat to site security and the health and safety of LLNL personnel. The RTRAM network sensor locations coincide with wind sector directions to provide thorough coverage of the one-square-mile site. These low-power sensors are supported by a central command center (CCC) and transmit measurement data back to the CCC computer through the LLNL telecommunications infrastructure. Alarm conditions are identified by comparing current data with predetermined threshold parameters and are validated by comparison with plausible dispersion modeling scenarios and prevailing meteorological conditions. Emergency response personnel are notified of alarm conditions by automatic radio- and computer-based notifications. A secure intranet provides emergency response personnel with current condition assessment data that enable them to direct field response efforts remotely. The RTRAM network has proven to be a reliable system since initial deployment in August 2001, and it maintains stability during inclement weather conditions.
Testosterone Changes Bladder and Kidney Structure in Juvenile Male Rats (2014)

In juvenile male rats testosterone was associated with increased bladder and renal mass, and increased bladder smooth muscle. Testosterone associated kidneys also appeared to have fewer but larger glomeruli. These data support an important role for sex hormones in structural and functional development of the bladder and kidney.
Restrictin: a chick neural extracellular matrix protein involved in cell attachment co-purifies with the cell recognition molecule F11 (1991)

We report here the characterization of restrictin, a novel chick neural extracellular matrix glycoprotein associated with the cell recognition molecule F11. Immunoaffinity chromatography using monoclonal antibody 23-13 directed to restrictin yield a major relative molecular mass band at 170 x 10(3) and minor bands at 160, 180, 250 and 320 x 10(3) which are immunologically related to each other. Neural cells attach on immobilized restrictin in a short-term adhesion assay. This adhesion can be blocked specifically by monoclonal or polyclonal antibodies to restrictin but not by antibodies to F11 or by the peptide GRGDSP. Antibodies to restrictin do not interfere with the fasciculation of retinal axons and the isolated restrictin does not stimulate the outgrowth of axons. In the developing nervous system, restrictin is localized in very restricted regions and is found within areas of F11 expression. The timing and pattern of expression of restrictin and its cell attachment activity suggest that it participates in developmental events of the nervous system.
Discovery of LPMO activity on hemicelluloses shows the importance of oxidative processes in plant cell wall degradation (2014)

The recently discovered lytic polysaccharide monooxygenases (LPMOs) are known to carry out oxidative cleavage of glycoside bonds in chitin and cellulose, thus boosting the activity of well-known hydrolytic depolymerizing enzymes. Because biomass-degrading microorganisms tend to produce a plethora of LPMOs, and considering the complexity and copolymeric nature of the plant cell wall, it has been speculated that some LPMOs may act on other substrates, in particular the hemicelluloses that tether to cellulose microfibrils. We demonstrate that an LPMO from Neurospora crassa, NcLPMO9C, indeed degrades various hemicelluloses, in particular xyloglucan. This activity was discovered using a glycan microarray-based screening method for detection of substrate specificities of carbohydrate-active enzymes, and further explored using defined oligomeric hemicelluloses, isolated polymeric hemicelluloses and cell walls. Products generated by NcLPMO9C were analyzed using high performance anion exchange chromatography and multidimensional mass spectrometry. We show that NcLPMO9C generates oxidized products from a variety of substrates and that its product profile differs from those of hydrolytic enzymes acting on the same substrates. The enzyme particularly acts on the glucose backbone of xyloglucan, accepting various substitutions (xylose, galactose) in almost all positions. Because the attachment of xyloglucan to cellulose hampers depolymerization of the latter, it is possible that the beneficial effect of the LPMOs that are present in current commercial cellulase mixtures in part is due to hitherto undetected LPMO activities on recalcitrant hemicellulose structures.