gebhart/patrepeval huggingface dataset:
Thermal Conditions in Rapid Thermal Processing System Using Circular Infrared Lamp (2000)

The thermal condition in a rapid thermal processing (RTP) system using circular infrared lamps is systematically studied, for the first time, based on the direct approach model using a ray trace simulation. This study focuses specifically on the temperature profile influenced by the connector, which is the dark region inevitably occupying a small part of the circular infrared lamp. Since the rays emitted from the lamp are distributed over the concentric circle region formed by the cylindrical reflectors, the influence of no radiation from the connector is significantly decreased resulting in the formation of a very shallow valley in the temperature profile of the silicon substrate below the connector. This conclusion is consistent with the actual applicability of the RTP system using the circular infrared lamps for very large diameter silicon substrates. © 2000 The Electrochemical Society. All rights reserved.
Transcriptional Errors in Human Immunodeficiency Virus Type 1 Generate Targets for T-Cell Responses (2009)

We measured T-cell responses to human immunodeficiency virus type 1 (HIV-1) cryptic epitopes encoded by regions of the viral genome not normally translated into viral proteins. T-cell responses to cryptic epitopes and to regions normally spliced out of the HIV-1 viral proteins Rev and Tat were detected in HIV-1-infected subjects.
Smart, Connected and Electric (2013)

This article introduces opportunities that are seen at the intersection of electrification, connectivity, and smart controls in the automobile industry. Computational Intelligence provides the vehicle the ability to reason, adapt, and learn based on historical usage data, the present operating conditions, and the predicted future states. Modern automobiles continue to grow in complexity and sophistication. Electrified powertrains now provide vastly improved fuel efficiency by utilizing high-voltage systems to overcome some of the shortcomings of traditional combustion engines. Smart controls have enabled a wealth of new vehicle features ranging from automatic climate control to vehicle dynamic control. Vehicle connectivity, having already empowered the driver through infotainment and telematics, now promises new computing resources and information that can be leveraged directly for improved vehicle performance. At the intersection of these three vehicle mega trends lies a field that is rich for development. In the future, drivers will benefit in everything from enhanced drivability to more durable vehicles.
Erythrocyte adhesion is modified by alterations in cellular tonicity and volume (2005)

We tested the hypothesis that dehydration-induced alterations in red blood cell (RBC) membrane organisation or composition contribute to sickle cell adhesion in sickle cell disease (SCD). To examine the role of RBC hydration in adhesion to the subendothelial matrix protein thrombospondin-1 (TSP), normal and sickle RBCs were incubated in buffers of varying tonicity and tested for adhesion to immobilised TSP under flow conditions. Sickle RBCs exhibited a decrease in TSP binding with increasing cell hydration (P<0.005), suggesting that cellular dehydration may contribute to TSP adhesion. Consistent with this hypothesis, normal RBCs showed an increase in TSP adhesion with increasing dehydration (P<0.01). Furthermore, increased TSP adhesion of normal RBCs could also be induced by isotonic dehydration using nystatin-sucrose buffers. Finally, TSP adhesion of both sickle RBCs and dehydrated normal RBCs was inhibited by the anionic polysaccharides, chondroitin sulphate A and high molecular weight dextran sulphate, but not by competitors of CD47-, band 3-, or RBC phosphatidylserine-mediated adhesion. More importantly, we found increased adhesion of nystatin-sucrose dehydrated normal mouse RBCs to kidney capillaries following re-infusion in vivo. In summary, these findings demonstrate that changes in hydration can significantly impact adhesion, causing normal erythrocytes to display adhesive properties similar to those of sickle cells and vice versa.
1‐[3‐Aminobenzisoxazol‐5′‐yl]‐3‐trifluoromethyl‐6‐ [2′‐(3‐(R)‐hydroxy‐N‐pyrrolidinyl)methyl‐ [1,1′]‐biphen‐4‐yl]‐1,4,5,6‐tetrahydropyrazolo‐[3,4‐c]‐pyridin‐7‐on# e (I) (BMS‐740808) a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Bias and Non-Diversity of Big Data in Artificial Intelligence: Focus on Retinal Diseases (2023)

Artificial intelligence (AI) applications in healthcare will have a potentially far-reaching impact on patient care, however issues regarding algorithmic bias and fairness have recently surfaced. There is a recognized lack of diversity in the available ophthalmic datasets, with 45% of the global population having no readily accessible representative images, leading to potential misrepresentations of their unique anatomic features and ocular pathology. AI applications in retinal disease may show less accuracy with underrepresented populations that may further widen the gap of health inequality if left unaddressed. Beyond disease symptomatology, social determinants of health must be integrated into our current paradigms of disease understanding, with the goal of more personalized care. AI has the potential to decrease global healthcare inequality, but it will need to be based on a more diverse, transparent and responsible use of healthcare data.
Development and validation of a miniaturized host range screening assay for bacteriophages (2021)

Abstract Antimicrobial resistance is a global health crisis, partly contributed by inappropriate use of antibiotics. The increasing emergence of multidrug resistant infections has led to the resurgent interest in bacteriophages as an alternative treatment. Current procedures assessing susceptibility and breadth of host range to bacteriophage are conducted using large-scale manual processes that are labor-intensive. The aim here was to establish and validate a scaled down methodology for high-throughput screening in order to reduce procedural footprint. Bacteriophages were isolated from wastewater samples and screened for specificity against 29 clinical Pseudomonas aeruginosa isolates and PA01 using a spot test (2 μL/ drop). Host range assessment was performed on four representative P. aeruginosa isolates using both double agar overlay assay on petri dishes and 24-well culture plates. The breadth of host range of bacteriophages that exhibited lytic activity on P. aeruginosa isolates were corroborated between the current standard practice of whole plate phage assay and 24-well phage assay. The high correlation achieved in this study confirms miniaturization as the first step in future automation that could test phage diversity and efficacy as antimicrobials.
The use of ASPEN Plus for the optimization of acid catalyzed hydrolysis polymerization process of TEOS (2019)

Sol-gel process is a flexible solution process for producing advanced materials in many industries. Odor problems caused by hydrogen sulphide also have been treated using a gel produced by sol-gel technology. While TEOS, water and nitric acid used as primary chemicals for the hydrogel, several other inhibitors and bactericides have been added to the gel in order to make the gel function properly for the requirement of suppressing Sulphur Reducing Bacteria (SRB). In this study, the main focus was to optimize the hydrolysis-polymerization process for this system using ASPEN Plus software in order to achieve efficient production at the end. The gelation time of the hydrogel reduces as the temperature of the final solution increases. To maintain a convenient residence time and to obtain the established gel, temperature control is essential in the first reactor. In order to control the temperature, thermodynamic conditions of the process has been taken into consideration. ASPEN Plus simulations have been performed in order to observe the outlet variations in the hydrolysis reactor with respect to the reactor temperature and heat duty. The kinetic coefficients have been taken from reference (1) &amp; (2) which considered similar conditions. It has been revealed that maintaining 1.5-1.66 kJ/sec heat duty generate the required temperature range of 28o C-70o C in the outflow with above 93% TEOS consumption.
Studies on the syntheses of analgesics. 41. Optical resolution of (.+-.)-N-cyclopropylmethyl-3-hydroxy-9-azamorphinan (studies on the syntheses of heterocyclic compounds. 669. (1976)

Optical resolution of (+)-N-cyclopropylmethyl-3-hydroxy-9-azamorphinan (I) was successfully effected with (+)-O, O-dibenzoyltartaric acid or (2R : 3R)-2'-nitrotartranilic acid as the resolution agent. The optically active compounds thus obtained were tested for their analgesic activity and antagonistic effect of morphine analgesia.
MERS-CoV ORF4b is a virulence factor involved in the inflammatory pathology induced in the lungs of mice (2022)

No vaccines or specific antiviral drugs are authorized against Middle East respiratory syndrome coronavirus (MERS-CoV) despite its high mortality rate and prevalence in dromedary camels. Since 2012, MERS-CoV has been causing sporadic zoonotic infections in humans, which poses a risk of genetic evolution to become a pandemic virus. MERS-CoV genome encodes five accessory proteins, 3, 4a, 4b, 5 and 8b for which limited information is available in the context of infection. This work describes 4b as a virulence factor in vivo, since the deletion mutant of a mouse-adapted MERS-CoV-Δ4b (MERS-CoV-MA-Δ4b) was completely attenuated in a humanized DPP4 knock-in mouse model, resulting in no mortality. Attenuation in the absence of 4b was associated with a significant reduction in lung pathology and chemokine expression levels at 4 and 6 days post-infection, suggesting that 4b contributed to the induction of lung inflammatory pathology. The accumulation of 4b in the nucleus in vivo was not relevant to virulence, since deletion of its nuclear localization signal led to 100% mortality. Interestingly, the presence of 4b protein was found to regulate autophagy in the lungs of mice, leading to upregulation of BECN1, ATG3 and LC3A mRNA. Further analysis in MRC-5 cell line showed that, in the context of infection, MERS-CoV-MA 4b inhibited autophagy, as confirmed by the increase of p62 and the decrease of ULK1 protein levels, either by direct or indirect mechanisms. Together, these results correlated autophagy activation in the absence of 4b with downregulation of a pathogenic inflammatory response, thus contributing to attenuation of MERS-CoV-MA-Δ4b.
Documented Rocky Mountain Spotted Fever in Wintertime (1982)

ROCKY Mountain spotted fever (RMSF) is the most severe rickettsial disease of man in North America and is generally considered to be a seasonal disease.<sup>1-3</sup>The overwhelming majority of cases occur between the months of April and October.<sup>4,5</sup>This mostly warm-weather period also happens to be the time of maximum activity of the ixodid ticks that serve as both reservoir and vector for the disease. We report a case of RMSF during a prolonged cold winter period in February 1981 in North Carolina. This case is interesting not only because of its temporal occurrence but also because the etiologic agent was isolated and there was no tick bite history associated with it. <h3>Report of a Case</h3> In early February 1981, a 6-year-old boy, a resident of rural eastern North Carolina who resides in a single-family dwelling on a partially cleared 3-acre wooded tract with his parents, two siblings
Light‐Directed Electrophoretic Deposition: A New Additive Manufacturing Technique for Arbitrarily Patterned 3D Composites (2014)

A versatile, new additive manufacturing technique based on electrophoretic deposition of colloids onto light-patterned photoelectrodes is demonstrated. Particles to be deposited move via electrophoresis and adhere to the illuminated regions of the electrode. This process is repeated with different materials and illumination patterns to fabricate arbitrarily patterned 3D multimaterial composites. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Screening for Previous Refractive Surgery in Eye Bank Corneas by Using Optical Coherence Tomography (2007)

OCT provides thickness, topography, and reflectivity maps of donor corneas without taking them out of preservation medium and container. The anterior curvature and the anterior/posterior stromal reflectivity ratio may be useful for detecting previous LASIK.
Generalized fast marching method for computing highest threatening trajectories with curvature constraints and detection ambiguities in distance and radial speed (2018)

Work presented at the 9th Conference on Curves and Surfaces, 2018, Arcachon
A Locally-Adaptive Metric for Contrast-Fusion of Noisy Multimodal Imagery (2000)

Abstract : We propose a new technique for reducing the effect of noise on contrast fusion of multimodal imagery, yielding higher quality results than can be obtained with previous methods. We rely on local non-parametric estimation of band gradient entropies as a relative measure of geometric structure. This work builds upon previous work by the author, and is exemplified with remote sensing applications. Quantitative measures of performance are given on ground-truth data, which indicate the advantages of the new technique over existing approaches.
Liver Enzyme Abnormalities in Patients With Atopic Dermatitis Treated With Mycophenolate Mofetil (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
A comparison of 18F-DCFPyL, 18F-NaF and 18F-FDG PET/CT in a prospective cohort of men with metastatic prostate cancer (2021)

<sup>18</sup>F-DCFPyL, <sup>18</sup>F-sodium fluoride (<sup>18</sup>F-NaF), and <sup>18</sup>F-FDG PET/CT were compared in a prospective cohort of men with metastatic prostate cancer (PCa). <b>Methods:</b> Sixty-seven men (group 1) with documented metastatic PCa underwent <sup>18</sup>F-DCFPyL and <sup>18</sup>F-NaF PET/CT and a subgroup of 30 men (group 2) underwent additional imaging with <sup>18</sup>F-FDG PET/CT. The tracers were compared for their detection rates, imaging concordance, associations with prostate-specific antigen (PSA), treatment at the time of imaging, and castration status. <b>Results:</b> Overall, 61 men had metastatic disease detected on one or more scans, and 6 men had no disease uptake on any of the PET/CT scans (and were subsequently excluded from the analysis). In group 1, <sup>18</sup>F-NaF detected significantly more metastatic lesions than <sup>18</sup>F-DCFPyL (median of 3 lesions vs. 2, <i>P</i> = 0.001) even after eliminating benign causes of <sup>18</sup>F-NaF uptake. This difference was particularly clear for men receiving treatment (<i>P</i> = 0.005) or who were castration-resistant (<i>P</i> = 0.014). The median percentage of bone lesions that were concordant on <sup>18</sup>F-DCFPyL and <sup>18</sup>F-NaF was 50%. In group 2, <sup>18</sup>F-DCFPyL detected more lesions than <sup>18</sup>F-FDG (median of 5 lesions vs. 2, <i>P</i> = 0.0003), regardless of PSA level, castration status, or treatment. The median percentage of lesions that were concordant on <sup>18</sup>F-DCFPyL and <sup>18</sup>F-FDG was 22.2%. This percentage was slightly higher for castration-resistant than castration-sensitive men (<i>P</i> = 0.048). <b>Conclusion:</b><sup>18</sup>F-DCFPyL PET/CT is the most versatile of the 3 PET agents for metastatic PCa; however, <sup>18</sup>F-NaF detects more bone metastases. Imaging reveals substantial tumor heterogeneity with only 50% concordance between <sup>18</sup>F-DCFPyL and <sup>18</sup>F-NaF and 22% concordance for <sup>18</sup>F-DCFPyL and <sup>18</sup>F-FDG. These findings indicate considerable phenotypic differences among metastatic lesions.
On the figure of merit of uncooled bolometers fabricated at INO (2016)

This paper reports the NETD values of various uncooled bolometers fabricated at INO. They are measured using an external readout circuit that emulates the readout scheme of a commercial ROIC. The measured NETD values range between 6 and 75 mK, depending on the pixel pitch and response time. Pixel pitches of 12, 17 and 35 μm are considered. The figure of merit of the characterized detectors is below 350 mK*ms.
Diagnostic capabilities of devices for cardiac resynchronization therapy (2010)

Atrial fibrillation and chronic heart failure often coexist. Asymptomatic atrial fibrillation is common in patients with known atrial fibrillation but also in patients with no history of previous atrial fibrillation. The enhanced diagnostic capabilities of modern implantable devices for cardiac resynchronization therapy allow collecting of data on the clinical status of the patient in addition to information on device performance and cardiac rhythm. We present a paradigmatic case of newly diagnosed atrial fibrillation with hemodynamic consequences detected by the diagnostics of a biventricular implantable cardioverter-defibrillator. We discuss the clinical utility of device-based monitoring and the potential advantages of wireless remote-control systems of implantable devices in the management of heart failure patients.
Efficient bandwidth allocation and call admission control for VBR service using UPC parameters (2000)

Provision of Quality-of-Service (QoS) guarantees is an important and challenging issue in the design of Asynchronous Transfer Mode (ATM) networks. Call Admission Control (CAC) is an integral part of the challenge and is closely related to other aspects of network designs such as traffic characterization and QoS specification. Since the Usage Parameter Control (UPC) parameters are the only standardized traffic characterizations, developing efficient CAC schemes based on UPC parameters is significant for the implementation of CAC on ATM switches. In this paper, we develop a CAC algorithm called TAP (derived from TAgged Probability) as well as two other CAC algorithms using the UPC parameters. These CAC algorithms are based on our observation that the loss-probability-to-overflow-probability ratio tends to decrease as the number of sources increases. By introducing the loss-probability-to-overflow-probability ratio K, we find that this ratio sheds light on increasing resource utilization while still guaranteeing QoS. Analysis, simulation, and numerical results have shown that the proposed TAP algorithm is simple and efficient. Copyright © 2000 John Wiley & Sons, Ltd.
Le traitement des prolactinomes par un nouvel agoniste dopaminergique (le CV 205-502) : résultats chez 48 patients. (1992)

peer reviewed
<title>Imaging of subsurface regions of random media by remote sensing</title> (1991)

The ability to selectively probe a random medium, even in the limit of isotropic scattering, suggests it should be possible to reconstruct images of a dense scattering medium from the information contained in the backscatter surface emission profile. Consideration of the imaging problem also requires knowledge of the impact that localized absorption at any site in the medium would have on the response of detectors at the surface. By applying the concept of importance used in reactor theory, we have calculated this relationship for various homogeneous media. This information was subsequently incorporated into several image reconstruction algorithms which employ a backprojection strategy. The algorithms were tested by applying them to simulated surface emission profile data for homogeneous scattering media with embedded arrays of black-body absorbers. The algorithms correctly identified the size and location of the arrays, resolved internal structural features, and showed significant improvement upon iteration.
Chemotherapy Acts as an Adjuvant to Convert the Tumor Microenvironment into a Highly Permissive State for Vaccination-Induced Antitumor Immunity (2013)

Multiple classes of pharmacologic agents have the potential to induce the expression and release of proinflammatory factors from dying tumor cells. As a result, these cells can in theory elicit an immune response through various defined mechanisms to permanently eradicate disseminated cancer. However, the impact of chemotherapy on the tumor-specific immune response in the context of the tumor microenvironment is largely unknown. Within the tumor microenvironment, the immune response promoted by chemotherapy is antagonized by an immune-suppressive milieu, and the balance of these opposing forces dictates the clinical course of disease. Here, we report that high antigen exposure within the tumor microenvironment following chemotherapy is sufficient to skew this balance in favor of a productive immune response. In elevating antigen exposure, chemotherapy can achieve long-term control of tumor progression without the need of an additional adjuvant. We found that chemotherapy initiated this phenomenon in the tumor microenvironment through an accumulation of dendritic cells, which stimulated CD8(+) T cells and the type I IFN pathway. From this conceptual base, we developed a simple approach to cancer therapy combining chemotherapy and vaccination that may be widely applicable.