gebhart/patrepeval huggingface dataset:
Protocol for a randomized controlled trial of electroacupuncture in the management of patients with axial spondyloarthritis in Singapore (E‐AcuSpA) (2021)

Abstract Background Despite therapeutic advances, treatment of patients with axial spondyloarthritis (axSpA) continue to pose as a challenge as many do not respond well to conventional Western medications, such as nonsteroidal anti‐inflammatory drugs (NSAIDs) and biologic disease‐modifying antirheumatic drugs (bDMARDs). Hence, acupuncture is a possible alternative. Some studies found electroacupuncture to be better than manual acupuncture, though no trials have been conducted in patients with axSpA. This clinical trial aims to evaluate the clinical efficacy, safety, and cost‐effectiveness of electroacupuncture compared to manual acupuncture for patients with axSpA. Methods/Design This randomized controlled trial will recruit 100 patients diagnosed with axSpA, who have active disease despite NSAIDs and bDMARDs. Eligible patients will be randomized to receive either electroacupuncture or manual acupuncture in a 1:1 ratio. All participants will receive standard rheumatologic care in addition to 20 acupuncture sessions. The mean difference in Bath Ankylosing Spondylitis Disease Activity Index score between the 2 groups over 12 weeks will serve as the primary outcome. Secondary outcomes include improvements in other clinical, quality of life, and economic outcomes over 24 weeks. All adverse events will be recorded. Discussion Results from this trial may provide evidence regarding the clinical effectiveness, safety, and cost‐effectiveness of electroacupuncture compared to manual acupuncture for patients with axSpA, and guide implementation into clinical practice. Limitations of this trial include the lack of patient blinding, use of a repeated measures design, and possible variation in acupuncture technique amongst the various Traditional Chinese Medicine practitioners.
Observation of electroweak production of two jets and a $Z$-boson pair with the ATLAS detector at the LHC (2020)

Electroweak symmetry breaking explains the origin of the masses of elementary particles through their interactions with the Higgs field. Besides the measurements of the Higgs boson properties, the study of the scattering of massive vector bosons with spin 1 allows the nature of electroweak symmetry breaking to be probed. Among all processes related to vector-boson scattering, the electroweak production of two jets and a Z-boson pair is a rare and important one. Here we report the observation of this process from proton–proton collision data corresponding to an integrated luminosity of 139 fb$^{−1}$ recorded at a centre-of-mass energy of 13 TeV with the ATLAS detector at the Large Hadron Collider. We consider two different final states originating from the decays of the Z-boson pair: one containing four charged leptons and another containing two charged leptons and two neutrinos. The hypothesis of no electroweak production is rejected with a statistical significance of 5.7σ, and the measured cross-section for electroweak production is consistent with the Standard Model prediction. In addition, we report cross-sections for inclusive production of a Z-boson pair and two jets for the two final states.
Supplementary Table S4 from Immunotherapy with a HER2-Targeting <i>Listeria</i> Induces HER2-Specific Immunity and Demonstrates Potential Therapeutic Effects in a Phase I Trial in Canine Osteosarcoma (2023)

&lt;p&gt;Signalment and primary tumor characteristics of dogs in the historical control group.&lt;/p&gt;
Correction: NKp30 expression is a prognostic immune biomarker for stratification of patients with intermediate-risk acute myeloid leukemia (2019)

[This corrects the article DOI: 10.18632/oncotarget.17747.].
An agent-based approach to real-time multimedia transmission over heterogeneous environments (1998)

An Agent-based Approach to Real-time Multimedia Transmission over Heterogeneous Environments by Elan Amir Doctor of Philosophy in Computer Science University of California at Berkeley Professor Randy H. Katz, co-Chair Professor Steven R. McCanne, co-Chair An enduring trait of the Internet is its heterogeneity. Evidence of this heterogeneity includes the wide range of network transmission rates, varying across many orders of magnitude, and the vast differences in computing power, ranging from PDA&amp;apos;s to supercomputers. These heterogeneities present significant barriers to the transmission of real-time multimedia data across groups. The barriers stem from the fact that in order to accommodate the entire gamut of group member characteristics, e.g., bandwidth availability or computing power, a source is required to transmit its data with properties matching the most constrained receiver. Instead, we would like to transmit media to multiple receivers at heterogeneous rates and properties tha...
Common-Channel Optical Physical-Layer Network Coding (2014)

We propose and experimentally demonstrate a coherent optical physical-layer network coding scheme on polarization-multiplexed differential quaternary phase-shift keying (PM-DQPSK) signals, in which the two PM-DQPSK signal components in the network-coded signal occupy the same channel and cannot be separated by conventional means of demultiplexing. In the scheme, network coding at intermediate nodes is realized by combining the two PM-DQPSK signals with a coupler. For network decoding at terminal nodes, one of the signal components is reconstructed and subtracted from the network-coded signal to obtain the other signal component. From its known bit sequence, waveform reconstruction of the signal to be subtracted is implemented by a lookup table. Carrier phase estimation for the reconstructed waveform utilizes the property that DQPSK signals have constant modulus at the sampling point. Experimental results show that, for 12-GBd PM-DQPSK signals, network decoding at a bit error rate of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> can be achieved, with 2.1-dB optical signal-to-noise ratio penalty relative to back-to-back transmission.
134-OR: Comparison of Glucose-Insulin Homeostasis in People with Postprandial Hypoglycemia after Gastric Bypass Surgery and Nadir Plasma Glucose &lt;50 mg/dl vs. &gt;50 mg/dl (2021)

Background: Mechanisms of postprandial hypoglycemia following gastric bypass (GB) surgery (PBH), remain incompletely understood. Thus, we aimed to assess the role of insulin secretion/beta-cell function (BCF), fractional hepatic insulin extraction (HE), insulin sensitivity (SI) and rate of glucose appearance (Ra) in patients with biochemically moderate and severe hypoglycemia.Methods: A total of 23 subjects with PBH (mean±SD age 41±12 years, BMI 28.1±6.1 kg/m2, 6.0±2.5 years since GB surgery) underwent an oral glucose tolerance test (75g of glucose), with frequent blood sampling for determination of glucose, insulin and C-peptide concentrations for up to 180minutes. Indices of BCF, HE, SI and Ra were calculated using the oral minimal model method and compared between subjects with nadir plasma glucose during the test below (severe hypo) and above 50mg/dL (moderate hypo).Results: Mean±SD nadir glucose was 43.3±6.0mg/dL in the severe hypo group and 60.1±9.1mg/dL in the moderate hypo group. Differences between the groups were found for indices of BCF, HE and Ra, whereas no significant differences were observed for SI (Figure 1).Conclusion: Present findings confirm three candidate mechanisms involved in PBH: increased BCF, diminished HE and faster Ra.View largeDownload slideView largeDownload slide DisclosureD. Herzig: None. M. Schiavon: None. A. Tripyla: None. V. Lehmann: None. J. Meier: None. S. Jainandunsing: None. C. Dalla man: Research Support; Self; Becton, Dickinson and Company, Sanofi-Aventis Deutschland GmbH. L. Bally: None.FundingSwiss National Science Foundation (PCEGP3_186978); Italian Ministry of Education, University and Research (Law 232/2016); University of Padova; Diabetes Center Berne
Optimization of the Conditions for Plasmid DNA Delivery and Transfection with Self-Assembled Hyaluronic Acid-Based Nanoparticles (2018)

Polymeric systems have been extensively studied as polyelectrolyte complexes to enhance the cellular delivery and transfection efficiency of genetic materials, such as plasmid DNA (pDNA). Here, self-assembled nanoparticles were formulated by complexation of hyaluronic acid (HA)-conjugated poly(ethylene glycol) (HA-PEG) and poly(ethylenimine) (HA-PEI), respectively, with pDNA creating relatively small, stable, and multifunctional nanoparticle complex formulations with high transfection efficiency. This formulation strategy offers high gene expression efficiency and negligible cytotoxicity in HeLa and A549 human lung cancer cell lines. To develop the ideal formulation, in vitro transfection efficiency was studied for three different nanoparticle formulations (HA-PEI/HA-PEG, HA-PEI, and HA-PEG) with different concentrations. The combination of the three polymers (HA, PEG, and PEI) was significant for the formulation to achieve the maximum gene expression results. The nanoparticles were found to be stable for up to a week at 4 °C conditions. Overall, these HA-based nanoparticles showed promising aspects that can be utilized in the designing of gene delivery vectors for cancer therapy.
DECIDE (2005)

Anonymity is one of the most controversial issues related to the Internet. It greatly encourages misdeeds such as piracy, defamation, and fraud. However, anonymity is important to protect the privacy of individuals and to support the freedom of speech. Identity escrow is a potential solution to achieving a balance between anonymity and identity. The basic idea is to utilize a two-tiered identity: the first-tier identity carries the minimal amount of information for normal use, and the second-tier identity bears precise information regarding the individual to be disclosed when necessary. In this paper, we introduce a decentralized identity escrow scheme called DECIDE. It has three identity tiers: anonymity, pseudonymity, and identity, and it has a high decentralization capability. We also present an analysis on three service models - online discussion community, whistleblowing, school networking - to explore the public acceptance of the proposed scheme.
Highly stable resistive switching on monocrystalline ZnO (2010)

We report on the achievement of planar memristive devices on monocrystalline ZnO substrates using Ti/Al and Pt/Au contacts with dimensions of 100 x 100 microm(2) and spacings of approximately 60 microm. Effects of both thermal and electro-forming processes on the switching characteristics are investigated. It is observed that the thermally formed devices exhibit an extremely large R(OFF)/R(ON) value of approximately 20 000. The electrically formed devices, on the other hand, demonstrate an exceptional switching stability, with R(OFF)/R(ON) variations of < 2% for durations of over 10(5) s and more than 1800 switching cycles. The dependence of the switching characteristics on the formation processes, as well as the metal electrodes, could be explained by an oxygen vacancy formation/annihilation and migration model.
4.64-bit/s/Hz 46.4-Gbps W-band direct-detection OFDM-RoF system employing two cascaded single-drive MZMs (2013)

A W-band direct-detection OFDM-RoF system with two cascaded single-drive MZM was experimentally demonstrated. With bit-loading algorithm, 46.4-Gb/s data-rate and 4.64-bit/s/Hz spectral efficiency transmission over 25-km fiber and 2-m wireless transmission was achieved.
Removing the Requirement for Deburr Runs on a Field Development Multizones Well Completion (2022)

Abstract A Metal Expandable Packer (MEP) as an Inner String Packer (ISP) that has the capability to run through multiple perforated zones, without the need for a deburr run was qualified for a BSP oil &amp; gas field development in Brunei. Four injectors and four producers will be developed across a stacked sand shale sequence, requiring zonal isolation (ZI) and flow control to maximize production. The inclusion of this MEP technology provides a robust life-of-well Cased Hole (CH) sealing system with inherent anchoring and removes the deburr run, reducing associated rig time and cost. Initial design for Shell Whale proved the sealing capability of the MEP after passing through a non-deburred 9-5/8″ perforated liner. The BSP well design and qualification required an MEP to pass through a 7″ cemented and perforated liner deployed on a 3-½" inner string comprising up to six zones – each zone with a mechanical sliding sleeve and control line for zonal Permanent Dowhole Pressure-Temperature Gauges (PDHG). Job planning was conducted to configure the MEP, PDHG and SSD to minimize the erosion risks and maximise the perforation interval. Maximum use of onshore sub-assembly and SIT was identified to improve offshore rig-up efficiency. BSP identified the worst-case load scenario with the MEP anchoring against the ID of the 7″ liner due to thermal, hydraulic, and ballooning effects by performing Wellcat simulation. Based on this simulation, the MEP product was successfully qualified in accordance with ISO 14310 V3 (and subsequent V0) including the load envelope. Thorough FEA modelling validated the design, expansion and sealing capabilities, and demonstrated that a burr height of 0.17″ generated damage within the seal will be closed and sealed post expansion. Following the FEA, a rigorous ISO 14310 qualification was completed. An estimated overall NPV improvement for the field development within the first two years compared to alternative swellable-type products, and the elimination of a further 2 days/well rig time (approximate) during well construction compared with a mechanical-type packer. Further application of the MEP on multi-zone completions will enhance the ZI (sealing) of the 7″ to 8 ½" rock face (cement assurance or cement replacement) and may ultimately lead to the multi zone completion deployed within the open hole (OH) delivering further substantial cost reduction.
Hydrodeoxygenation of C4–C6 sugar alcohols to diols or mono-alcohols with the retention of the carbon chain over a silica-supported tungsten oxide-modified platinum catalyst (2021)

Sugar alcohols can be converted to mono-alcohols in good yields over a Pt–WO<sub>x</sub>/SiO<sub>2</sub> catalyst without C–C dissociation, and 1,4-butanediol and 1,4-anhydroxylitol can also be produced in good yields with related systems.
New insights into redox based resistive switches (2013)

Resistive Switching Memories (RRAM) are one of the most promising candidates for future memory devices. Among other emerging RRAM concepts redox based resistive switches (ReRAM) attracted high attention to replace conventional FLASH technology. Here we show both on experimental and theoretical level new insights into nanoionic resistive switches. Of particular interest are recently discovered non equilibrium states and their potential impact on the device behavior. The strong non linear switching kinetics and redox reactions prior to the switching event in cation based memory cells will be further discussed. Moreover, the effect of quantized resistance values is shown in respect to the ultimate scalability of ReRAMs.
Hydrogenation of α-oxophosphonates with molecular hydrogen catalyzed by palladium on carbon carrier as synthesis procedure for α-hydroxyphosphonates (2007)

Hydrogenation with molecular hydrogen of substituted benzoylphosphonic acids ethyl esters provides a convenient preparation method for diethyl [hydroxy(aryl)methyl]phosphonates. Both the palladium on activated carbon and the palladium immobilized in a chitosan matrix applied on a carbon carrier sibunit can be employed as catalysts.
Woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis virus in a common host (1991)

Chronic infection with hepatitis B viruses (hepadnaviruses) is a major cause of hepatocellular carcinoma (HCC), but the incubation time varies from 1 to 2 years to several decades in different host species infected with indigenous viruses. To discern the influence of viral and host factors on the kinetics of induction of HCC, we exploited the recent observation that ground squirrel hepatitis virus (GSHV) is infectious in woodchucks (C. Seeger, P. L. Marion, D. Ganem, and H. E. Varmus, J. Virol. 61:3241-3247, 1987) to compare the pathogenic potential of GSHV and woodchuck hepatitis virus (WHV) in chronically infected woodchucks. Chronic GSHV infection in woodchucks produces mild to moderate portal hepatitis, similar to that observed in woodchucks chronically infected with WHV. However, HCC developed in GSHV carriers about 18 months later than in WHV carriers. Thus, although both viruses are oncogenic in woodchucks, GSHV and WHV differ in oncogenic determinants that can affect the kinetics of appearance of HCC in chronically infected animals.
New Intumescent Formulations of Fire-retardant Polypropylene—Discussion of the Free Radical Mechanism of the Formation of Carbonaceous Protective Material During the Thermo-oxidative Treatment of the Additives (1996)

The study compares five new intumescent additive mixtures and a carbonizing additive system with the ammonium polyphosphate–pentaerythritol system and additive formulations previously developed in laboratory in terms of fire retardancy of polypropylene-based formulations. The mixture of diammonium pyrophosphate and polyols produced by agrochemical industry xylitol and d-sorbitol (carbonization agent) are FR additive mixtures of interest for polyolefins. Moreover, the FR performance of the mixture of ammonium polyphosphate and polyamide-6 is reported. It is proposed that boric acid salts have to be developed as precursors for carbonization catalytic species. A thermal analysis study shows that FR performances and amounts of carbonaceous materials resulting from the thermal degradation of the additive mixtures are not related. An additional compilation of previous spectroscopic studies by the laboratory confirms that the intumescent process results from the formation of polyaromatic species and that FR systems maintain acidic species in a relatively high temperature range. An ESR study discusses the presence of π radicals in the protective coating formed using the additive systems. It provides information on the size of the carbonaceous structures in the materials and the presence of crystalline phases in the coating. Finally, the participation of free radicals in the formation of chemical bonds between the materials produced from the additives and the products of the degradation of the polymer is discussed.
Localisation and interaction for augmented maps (2005)

Paper-based cartographic maps provide highly detailed information visualisation with unrivalled fidelity and information density. Moreover, the physical properties of paper afford simple interactions for browsing a map or focusing on individual details, managing concurrent access for multiple users and general malleability. However, printed maps are static displays and while computer-based map displays can support dynamic information, they lack the nice properties of real maps identified above. We address these shortcomings by presenting a system to augment printed maps with digital graphical information and user interface components. These augmentations complement the properties of the printed information in that they are dynamic, permit layer selection and provide complex computer mediated interactions with geographically embedded information and user interface controls. Two methods are presented which exploit the benefits of using tangible artifacts for such interactions.
Spectroscopic and magnetic properties of an iodo CoI tripodal phosphine complex (2012)

Reaction of the tripodal phosphine ligand 1,1,1-tris((diphenylphosphino)phenyl)ethane (PhP3) with CoI(2) spontaneously generates a one-electron reduced complex, [(PhP3)Co(I)(I)] (1). The crystal structure of 1 reveals a distorted tetrahedral environment, with an apical Co-I bond distance of ~2.52 Å. Co(II/I) redox occurs at an unusually high potential (+0.38 V vs. SCE). The electronic absorption spectrum of 1 exhibits an MLCT peak at 320 nm (ε = 8790 M(-1) cm(-1)) and a d-d feature at 850 nm (ε = 840 M(-1) cm(-1)). Two more d-d bands are observed in the NIR region, 8650 (ε = 450) and 7950 cm(-1) (ε = 430 M(-1) cm(-1)). Temperature dependent magnetic measurements (SQUID) on 1 (solid state, 20-300 K) give μ(eff) = 2.99(6) μ(B), consistent with an S = 1 ground state. Magnetic susceptibilities below 20 K are consistent with a zero field splitting (zfs) |D| = 8 cm(-1). DFT calculations also support a spin-triplet ground state for 1, as optimized (6-31G*/PW91) geometries (S = 1) closely match the X-ray structure. EPR measurements performed in parallel mode (X-band; 0-15,000 G, 15 K) on polycrystalline 1 or frozen solutions of 1 (THF/toluene) exhibit a feature at g≈ 4 that arises from a (Δm = 2) transition within the M(S) = <+1,-1> manifold. Below 10 K, the EPR signal decreases significantly, consistent with a solution zfs parameter (|D|≈ 8 cm(-1)) similar to that obtained from SQUID measurements. Our work provides an EPR signature for high-spin Co(I) in trigonal ligation.
Synthesis and Characterization of High-Photoactivity Electrodeposited Cu2O Solar Absorber by Photoelectrochemistry and Ultrafast Spectroscopy (2012)

We present a systematic study on the effects of electrodeposition parameters on the photoelectrochemical properties of Cu2O. The influence of deposition variables (temperature, pH, and deposition current density) on conductivity has been widely explored in the past for this semiconductor, but the optimization of the electrodeposition process for the photoelectrochemical response in aqueous solutions under AM 1.5 illumination has received far less attention. In this work, we analyze the photoactivity of Cu2O films deposited at different conditions and correlate the photoresponse to morphology, film orientation, and electrical properties. The photoelectrochemical response was measured by linear sweep voltammetry under chopped simulated AM 1.5 illumination. The highest photocurrent obtained was −2.4 mA cm–2 at 0.25 V vs RHE for a film thickness of 1.3 μm. This is the highest reported value reached so far for this material in an aqueous electrolyte under AM 1.5 illumination. The optical and electrical properties of the most photoactive electrode were investigated by UV–vis spectroscopy and electrochemical impedance, while the minority carrier lifetime and diffusion length were measured by optical-pump THz-probe spectroscopy.
An integrated network approach identifies the isobutanol response network of Escherichia coli (2009)

Isobutanol has emerged as a potential biofuel due to recent metabolic engineering efforts. Here we used gene expression and transcription network connectivity data, genetic knockouts, and network component analysis (NCA) to map the initial isobutanol response network of Escherichia coli under aerobic conditions. NCA revealed profound perturbations to respiration. Further investigation showed ArcA as an important mediator of this response. Quinone/quinol malfunction was postulated to activate ArcA, Fur, and PhoB in this study. In support of this hypothesis, quinone-linked ArcA and Fur target expressions were significantly less perturbed by isobutanol under fermentative growth whereas quinol-linked PhoB target expressions remained activated, and isobutanol impeded growth on glycerol, which requires quinones, more than on glucose. In addition, ethanol, n-butanol, and isobutanol response networks were compared. n-Butanol and isobutanol responses were qualitatively similar, whereas ethanol had notable induction differences of pspABCDE and ndh, whose gene products manage proton motive force. The network described here could aid design and comprehension of alcohol tolerance, whereas the approach provides a general framework to characterize complex phenomena at the systems level.