gebhart/patrepeval huggingface dataset:
Actinomycin D binding to oligonucleotides with 5'd(GCGC)3' sequences. Definitive proton and phosphorus-31 NMR evidence for two distinct d(GC) 1:1 adducts and for adjacent site binding in a unique 2:1 adduct (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTActinomycin D binding to oligonucleotides with 5'd(GCGC)3' sequences. Definitive proton and phosphorus-31 NMR evidence for two distinct d(GC) 1:1 adducts and for adjacent site binding in a unique 2:1 adductW. David. Wilson, Robert L. Jones, Gerald. Zon, Elwood V. Scott, Debra L. Banville, and Luigi G. MarzilliCite this: J. Am. Chem. Soc. 1986, 108, 22, 7113–7114Publication Date (Print):October 1, 1986Publication History Published online1 May 2002Published inissue 1 October 1986https://doi.org/10.1021/ja00282a051RIGHTS & PERMISSIONSArticle Views74Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (301 KB) Get e-Alerts Get e-Alerts
A structure and activity relationship for single-walled carbon nanotube growth confirmed by in situ observations and modeling (2020)

The structure and phase transformation of a cobalt (Co) catalyst, during single walled carbon nanotube (SWCNT) growth, is elucidated for inactive, active and deactivated nanoparticles by in situ imaging using an environmental transmission electron microscope. During nanotube growth, the structure was analyzed using Miller indices to determine the types of planes that favor anchoring or liftoff of nanotubes from the Co catalyst. Density functional theory was further applied to model the catalyst interactions to compare the work of adhesion of the catalyst's faceted planes to understand the interactions of different Miller planes with the graphene structure. Through in-depth studies of multiple distinct Co nanoparticles, we established a dominant nanoparticle phase for SWCNT growth. In addition, we identified the preferred lattice planes and a threshold for work of adhesion to allow the anchoring and liftoff of SWCNTs.
Figure S1 from Medium-throughput Drug Screening of Patient-derived Organoids from Colorectal Peritoneal Metastases to Direct Personalized Therapy (2023)

&lt;p&gt;Characterisation of CRPM tissue and peritonoids.&lt;/p&gt;
Bulk acoustic wave resonator with suppressed energy loss using improved lateral structure (2014)

A bulk acoustic wave (BAW) resonator with suppressed energy loss is proposed. Implemented with air edge reflector and current spreading electrode along the perimeter region of the BAW, the resonator successfully suppresses the acoustic wave leakage and the electric energy loss as well. As results of optimized lateral structure, the Q-factor at anti-resonance frequency (Qa) is significantly improved to over 2100. Furthermore, the peak insertion loss exhibits as low as 0.04dB and effective electro-mechanical coupling coefficient (kt2), which is essential to achieve wide band-width of RF filters, is 6.54%.
Enhancement of room temperature magnetoresistance in double perovskite ferrimagnets (2000)

The double perovskite Sr2FeMoO6 is a half-metallic ferrimagnet exhibiting significant magnetoresistance (MR) at 300 K in a magnetic field H&amp;lt;2 kOe. A preliminary study of the influence of isovalent and aliovalent substitutions for Sr2+ on the magnitude of the room-temperature MR is reported. Of the polycrystalline samples, Sr1.9A0.1FeMoO6 (A=Ca, Ba, La or Pr), the best result was obtained with the Ba(0.1) sample, which showed a factor of 2 enhancement of the MR over that previously reported for Sr2FeMoO6.
A Gröbner-Bases Approach to Syndrome-Based Fast Chase Decoding of Reed–Solomon Codes (2022)

We present a simple syndrome-based fast Chase decoding algorithm for Reed–Solomon (RS) codes. Such an algorithm was initially presented by Wu (IEEE Trans. IT, Jan. 2012), building on properties of the Berlekamp–Massey (BM) algorithm. Wu devised a fast polynomial-update algorithm to construct the error-locator polynomial (ELP) as the solution of a certain linear-feedback shift register (LFSR) synthesis problem. This results in a conceptually complicated algorithm, divided into 8 subtly different cases. Moreover, Wu’s polynomial-update algorithm is not immediately suitable for working with vectors of evaluations. Therefore, complicated modifications were required in order to achieve a true “one-pass” Chase decoding algorithm, that is, a Chase decoding algorithm requiring <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$O(n)$ </tex-math></inline-formula> operations per modified coordinate, where <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$n$ </tex-math></inline-formula> is the RS code length. The main result of the current paper is a conceptually simple syndrome-based fast Chase decoding of RS codes. Instead of developing a theory from scratch, we use the well-established theory of Gröbner bases for modules over <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mathbb {F}_{q}[X]$ </tex-math></inline-formula> (where <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mathbb {F}_{q}$ </tex-math></inline-formula> is the finite field of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$q$ </tex-math></inline-formula> elements, for <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$q$ </tex-math></inline-formula> a prime power). The basic observation is that instead of Wu’s LFSR synthesis problem, it is much simpler to consider “the right” minimization problem over a <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">module</i> . The solution to this minimization problem is a simple polynomial-update algorithm that avoids syndrome updates and works seamlessly with vectors of evaluations. As a result, we obtain a conceptually simple algorithm for one-pass Chase decoding of RS codes. Our algorithm is general enough to work with any algorithm that finds a Gröbner basis for the solution module of the key equation as the initial algorithm (including the Euclidean algorithm), and it is not tied only to the BM algorithm.
Supplementary Figure from Long-Acting Recombinant Human Interleukin-7, NT-I7, Increases Cytotoxic CD8 T Cells and Enhances Survival in Mouse Glioma Models (2023)

Supplementary Figure from Long-Acting Recombinant Human Interleukin-7, NT-I7, Increases Cytotoxic CD8 T Cells and Enhances Survival in Mouse Glioma Models
Detection of Radial and Axial Magnet Defects in PM Synchronous Motors (2022)

This paper presents a novel method for the detection of magnet cracks or defects through analysis of back electromotive force (EMF) voltage, line current and vibration signals for radial flux permanent magnet (PM) synchronous motors. An integer slot PM motor with 12 poles is used in the study. Different types of faults including both radial and axial magnet crack defects are studied in detail. Random forest based magnet defect detection is utilized and a classification scheme is proposed in order to analyze the changes in the harmonics arising from radial or axial magnet defects. The results clearly show that the harmonics is altered in such a manner that it is possible to determine not only the magnet fault but the type of the magnet defect using motor voltage, current or vibration data.
ZINC THERAPY INDUCTION OF INTESTINAL METALLOTHIONEIN IN WILSON'S DISEASE (1999)

1University of Michigan Medical School Departments of Human Genetics and Internal Medicine Ann Arbor, MI Reprint requests and correspondence: George J Brewer, MD, 1301 Catherine Street, Medical Science Bldg. II/4708, Ann Arbor, MI 48109-0618
INTRAPREDICTIONBY TEMPLATE MATCHING (2006)

Intra prediction isaneffective methodforreducing the codedinformation ofanimageoranintra framewithin a video sequence. Theconventional method today istocreate asample predictor block byextrapolating thereconstructed pixels surrounding thetarget block tobecoded. Thesample predictor blockissubtracted fromthetarget blockandthe resulting residual codedusing transformation, quantization andentropy coding. Thisisaneffective method forsample predictor blockcreation inmostsequences. Howeverthe extrapolation methodisnotabletorepresent sample prediction blocks withcomplex texture. Furthermore, pixels thatarefarfromthesurrounding pixels areusually badly predicted. Inthis paper, anewmethod forsample predictor creation bytemplate matching inaregion ofreconstructed pixels ispresented. Improvements incoding efficiency by morethan11% inbitrate wereachieved. IndexTerms- Videocoding, Imagecoding, Image generation
Sustainable thermoplastic elastomers derived from renewable cellulose, rosin and fatty acids (2013)

Two series of graft copolymers, cellulose-g-poly(n-butyl acrylate-co-dehydroabietic ethyl methacrylate) (Cell-g-P(BA-co-DAEMA)) and cellulose-g-poly(lauryl methacrylate-co-dehydroabietic ethyl methacrylate) (Cell-g-P(LMA-co-DAEMA)), were prepared by “grafting from” atom transfer radical polymerization (ATRP). In these novel graft copolymers, cellulose, DAEMA (derived from rosin), and LMA (derived from fatty acids) are all sourced from renewable natural resources. The “grafting from” ATRP strategy allows the preparation of high molecular weight graft copolymers consisting of a cellulose main chain with acrylate copolymer side chains. By manipulating the monomer ratios in the P(BA-co-DAEMA) and P(LMA-co-DAEMA) side chains, graft copolymers with varying glass transition temperatures (−50–60 °C) were obtained. Tensile stress–strain and creep compliance testing were employed to characterize mechanical properties. These novel graft copolymers did not exhibit linear elastic properties above about 1% strain, but they did manifest remarkable elasticity at strains of 500% or more. These results suggest that these cellulose-based, acrylate side-chain polymers are potential candidates for service as thermoplastic elastomers materials in applications requiring high elasticity without rupture at high strains.
High transferrin saturation predicts inferior clinical outcomes in patients with myelodysplastic syndromes (2022)

Iron overload (IO) reflected by elevated ferritin is associated with increased mortality in myelodysplastic syndromes (MDS), however, ferritin is an imperfect metric. Elevated labile plasma iron correlates with clinical outcomes and transferrin saturation (TSAT) >80%, but is not readily measurable. The trajectory of TSAT, and its association with clinical outcomes remain undefined. Canadian MDS registry patients were evaluated. Mean TSAT, mean ferritin and transfusion dose density (TDD) were determined. Survival was evaluated by TSAT and ferritin (<50%, 50-80%, >80%), (≤500 μg/L, 501-800 μg/L, >800 μg/L). In 718 patients, median age was 74 years; 12%, 31%, 29%, 15% and 13% were IPSS-R very low, low, intermediate, high and very high. TSAT and ferritin were moderately correlated (r=0.63, P<0.0001). TSAT increased over time in transfusion- dependent patients (P=0.006). Higher TSAT and ferritin were associated with inferior 5-year overall (OS), progression- free (PFS), and leukemia-free survival (LFS) (P≤0.008) and higher TDD with inferior 5-year OS. TSAT >80% trended with inferior cardiac death-free survival (P=0.053). In univariate analysis, age, IPSS-R, blast percentage by Eastern Cooperative Oncology Group Performance Status, frailty, Charlson Comorbidity Index, iron chelation (Y/N), TDD, TSAT and ferritin were significantly associated with inferior OS. By multivariable analysis, TSAT >80% (P=0.007) remained significant for OS (R2 30.3%). In MDS, TSAT >80% and ferritin >800 μg/L portended inferior OS, PFS and LFS. TSAT may indicate the presence of oxidative stress, and is readily measurable in a clinical setting. The relationship between TSAT and cardiac death-free survival warrants further study.
Effects of Mn Additive on Dielectric and Piezoelectric Properties of (Na0.5K0.5)NbO3–BaZrO3–(Bi0.5K0.5)TiO3Ternary System (2012)

High-density perovskite titanate zirconate-modified potassium niobate solid solutions 0.92(Na0.5K0.5)NbO3–xBaZrO3–(0.08-x)(Bi0.5K0.5)TiO3 (BBK) and Mn-added BBK have been prepared by the solid-state reaction method. The phase diagram summarized from the dielectric measurement reveals that there exists a tetragonal–rhombohedral morphotropic phase boundary (MPB) for both solid solutions. The piezoelectric properties show enhanced behavior at around the tetragonal–rhombohedral MPB. Mn addition could increase Qm as well as kp and d33. The behavior is attributed to oxygen vacancy formation and grain size growth, respectively.
Lightning Pose: improved animal pose estimation via semi-supervised learning, Bayesian ensembling, and cloud-native open-source tools (2023)

Contemporary pose estimation methods enable precise measurements of behavior via supervised deep learning with hand-labeled video frames. Although effective in many cases, the supervised approach requires extensive labeling and often produces outputs that are unreliable for downstream analyses. Here, we introduce "Lightning Pose," an efficient pose estimation package with three algorithmic contributions. First, in addition to training on a few labeled video frames, we use many unlabeled videos and penalize the network whenever its predictions violate motion continuity, multiple-view geometry, and posture plausibility (semi-supervised learning). Second, we introduce a network architecture that resolves occlusions by predicting pose on any given frame using surrounding unlabeled frames. Third, we refine the pose predictions post-hoc by combining ensembling and Kalman smoothing. Together, these components render pose trajectories more accurate and scientifically usable. We release a cloud application that allows users to label data, train networks, and predict new videos directly from the browser.
In Situ IR Spectroscopic Investigation of Alumina ALD on Porous Silica Films: Thermal versus Plasma-Enhanced ALD (2014)

A novel in situ infrared (IR) approach is demonstrated for investigating and identifying ALD surface reactions during both the steady state and the initial growth regime. The unique combination of reflection–absorption IR spectroscopy in grazing incidence mode with a high surface area reflecting substrate allows for ALD process monitoring with an acceptable acquisition time and a high sensitivity in the entire mid-IR spectral region. Using a mesoporous silica film deposited on a reflecting platinum layer as substrate, the thermal and plasma-enhanced ALD processes of alumina with use of trimethylaluminum (TMA) are compared. Due to the high sensitivity of the method, the relative amount of surface hydroxyl groups added or removed during the process could be determined versus the number of ALD half-cycles. These data reveal substrate-inhibited growth on the silica surface for the thermal process with use of TMA and water, as compared to direct growth for the plasma-based ALD process with use of TMA and O2 plasma. This different behavior could be linked to the formation of Si–CH3 surface groups after the first precursor pulse, as evidenced by the raw IR spectra. It is found that the oxygen radicals in the plasma can remove these surface groups during the next few ALD cycles, while the H2O molecules cannot, thus explaining the initial slower growth for the thermal process.
Diode-Pumped Tm,Ho:GdVO_4 Laser at Room Temperature (2005)

High quality Tm,Ho:GdVO4 crystal was grown by Floating-zone method.
 Diode pumped continuous wave operation in 2.05 μm was demonstrated at room
 temperature. Slope efficiency of 18 % and threshold of pump power of 600 mW were
 achieved at 20 °C.
Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu 2 /mGlu 4 receptor heterodimers (2021)

Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that regulate various aspects of central nervous system processing in normal physiology and in disease. They are thought to function as disulfide-linked homodimers, but studies have suggested that mGluRs can form functional heterodimers in cell lines. Using selective allosteric ligands, ex vivo brain slice electrophysiology, and optogenetic approaches, we found that two mGluR subtypes-mGluR2 and mGluR4 (or mGlu<sub>2</sub> and mGlu<sub>4</sub>)-exist as functional heterodimers that regulate excitatory transmission in a synapse-specific manner within the rodent medial prefrontal cortex (mPFC). Activation of mGlu<sub>2</sub>/mGlu<sub>4</sub> heterodimers inhibited glutamatergic signaling at thalamo-mPFC synapses but not at hippocampus-mPFC or amygdala-mPFC synapses. These findings raise the possibility that selectively targeting these heterodimers could be a therapeutic strategy for some neurologic and neuropsychiatric disorders involving specific brain circuits.
DOP021 Long-term effectiveness and safety of vedolizumab in patients with Crohn's disease: 5-year cumulative exposure of GEMINI 2 completers rolling into the GEMINI open-label extension study (2017)

Background: Vedolizumab (VDZ), a humanised monoclonal antibody that targets α4β7 integrin, is approved for moderately to severely active Crohn's disease (CD) and ulcerative colitis. The GEMINI open-label extension (OLE) trial is an ongoing study investigating the long-term safety of VDZ (NCT00790933). Here we report the 5-year exploratory analyses of effectiveness and safety in patients (pts) with CD who had completed GEMINI 2 [1] and were enrolled in GEMINI OLE. Methods: Analyses included pts who had responded to VDZ induction at Week (Wk) 6 and received VDZ maintenance (every 8 or 4 wks; data were combined) to Wk 52 of GEMINI 2, followed by VDZ every 4 wks in GEMINI OLE. Pts with 248 wks of cumulative VDZ treatment (data were collected from 22 May 2009 to 21 May 2015) were assessed for clinical response (decrease in Harvey–Bradshaw Index [HBI] of ≥3 points from baseline [BL]), clinical remission (HBI ≤4) and health-related quality of life (HRQoL), including IBD Questionnaire (IBDQ) and Euro Quality of Life-5D visual analogue scale (EQ-5D VAS). Safety was also assessed. Results: Of 308 pts in GEMINI 2 who responded to VDZ induction at Wk 6 and received VDZ in maintenance, 146 (47%) completed VDZ maintenance and were enrolled in GEMINI OLE (anti-TNFα-naïve n=81; anti-TNFα failure n=57). At the time of this analysis, 61 pts had completed 248 wks of cumulative VDZ treatment, 58 had discontinued (n=11 [19%] due to lack of continued benefit) and 27 are ongoing (have not yet reached 248 wks of treatment). Of pts with data at Wk 248 (n=61), 95% had clinical response and 89% were in remission (Table). HRQoL improvements were observed at Wk 248, with mean change from BL IBDQ and EQ-5D-VAS scores of 59.4 and 29.8, respectively. In the safety population, 134 pts had adverse events (AEs); 15 discontinued due to AEs. Serious AEs were reported in 41 pts (in 3 pts these were drug-related; 8 pts discontinued as a consequence of serious AEs). One death (not drug-related; motor accident) was reported. Table 1. Effectiveness outcomes in patients with CD and cumulative VDZ exposure for up to 248 wks Conclusions: Long-term VDZ therapy (∼5 years) was associated with clinical benefits including clinical response, clinical remission and HRQoL improvements in pts with moderately to severely active CD who responded at Wk 6, completed GEMINI 2 and enrolled in OLE. Long-term VDZ therapy was associated with no unanticipated AEs, and the safety profile was consistent with that previously observed in a 3-year interim analysis of the OLE study. References: [1] Sandborn WJ, Feagan BG, Rutgeerts P, et al., (2013), Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease, N Engl J Med, 711–21
Antenne RFID UHF pour applications en champ proche et champ lointain (2013)

National audience
Adventure of Gene Therapy Into the Brain: A New Era for Cardiovascular Gene Therapy (2000)

ene therapy is emerging as a potential strategy for the treatment of cardiovascular diseases such as peripheral arterial disease, myocardial infarction, restenosis after angioplasty, and vascular bypass graft occlusion, for which current therapy is often inadequate. The first federally approved human gene therapy protocol started on September 14, 1990, in patients with adenosine deaminase deficiency. Ten years after the commencement of the first trial, more than 30 clinical studies of gene therapy for cardiovascular disease are under investigation. First, Isner and colleagues demonstrated the potential utility of gene therapy using an angiogenic growth factor (vascular endothelial growth factor [VEGF]) for the treatment of critical limb ischemia in human patients. More recently, his group revealed the usefulness of gene therapy using VEGF to treat ischemic heart disease. Although there are still many unresolved issues, human gene therapy for cardiovascular disease is now becoming a reality.
Rational Molecular Design and EPC Synthesis of a Type VIβ-Turn Inducing Peptide Mimetic (2001)

A fruitful combination of molecular dynamics based design and modern synthetic reactions led to a conformatively rigidized cis-peptidyl proline surrogate (see picture). NMR spectroscopic experiments clearly show the existance of type VIa β-turn properties that are of interest in drug discovery. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2001/z16752_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Experiments on the transportation of a magnetized plasma stream in the GOL-3 facility (2016)

The program of the deep upgrade of the GOL-3 multiple-mirror trap is presented. The upgrade is aimed at creating a new GOL-NB open trap located at the GOL-3 site and intended to directly demonstrate the efficiency of using multiple-mirror magnetic cells to improve longitudinal plasma confinement in a gasdynamic open trap. The GOL-NB device will consist of a new central trap, adjoint cells with a multiple-mirror magnetic field, and end tanks (magnetic flux expanders). Plasma in the central trap will be heated by neutral beam injection with a power of up to 1.5 MW and duration of 1 ms. At present, physical experiments directed at developing plasma technologies that are novel for this facility are being carried out using the 6-m-long autonomous part of the GOL-3 solenoid. The aim of this work was to develop a method for filling the central trap with a low-temperature start plasma. Transportation of a plasma stream from an arc source over a distance of 3 m in a uniform magnetic field with an induction of 0.5–4.5 T is demonstrated. In these experiments, the axial plasma density was (1–4) × 1020 m–3 and the mirror ratio varied from 5 to 60. In general, the experiments confirmed the correctness of the adopted decisions for the start plasma source of the GOL-NB device.