gebhart/patrepeval huggingface dataset:
Acylation of some 6-aminouracil derivatives (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcylation of some 6-aminouracil derivativesJaewon L. Shim, Rolf Niess, and Arthur D. BroomCite this: J. Org. Chem. 1972, 37, 4, 578–581Publication Date (Print):February 1, 1972Publication History Published online1 May 2002Published inissue 1 February 1972https://pubs.acs.org/doi/10.1021/jo00969a013https://doi.org/10.1021/jo00969a013research-articleACS PublicationsRequest reuse permissionsArticle Views391Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis of Heterofunctionalised Diamines and Triamines by Hydroaminomethylation of Diallyl Ethers, -silanes, or -amines (1999)

Starting from diallyl ethers, -silanes, or -amines various di- or triamines with potential biological activity are obtainable in one step by RhI-catalysed hydroaminomethylation of the alkene moieties in the presence of synthesis gas.
Faculty Opinions recommendation of Rare influenza A (H3N2) variants with reduced sensitivity to antiviral drugs. (2010)

In 2007 and 2008 in Myanmar, we detected influenza viruses A (H3N2) that exhibited reduced sensitivity to both zanamivir and amantadine. These rare and naturally occurring viruses harbored a novel Q136K mutation in neuraminidase and S31N mutation in M2. PMID: 20202427
Digital Implementation of Stator and Rotor Flux-Linkage Observers and a Stator-Current Observer for Deadbeat Direct Torque Control of Induction Machines (2009)

Properly formed discrete-time recursive models of a stator and rotor flux-linkage observer are presented. A model delay in the flux-linkage observer, which hindered previous work, is identified. To remove this delay, a new stationary frame current observer is developed and experimentally verified. With this new observer system, the flux linkages are properly estimated for the next sample instant, thus removing the computational delay. The improved and the delayed flux observer are evaluated in a deadbeat direct torque control algorithm.
Edited film alignment via selective Hough transform and accurate template matching (2017)

Edited film alignment is the post-production process of finding small parts of unedited footage that temporally and spatially match an edited film. The huge amount of data to be processed makes significant downsampling of the videos essential in real-life applications. Simultaneously, professional users demand that the task be achieved with frame and pixel-level accuracy. We propose a novel selective Hough transform (SHT) and an accurate template matching method to address the difficult trade-off between accuracy and scalability. For robust temporal alignment, SHT investigates the selectivity of frame-level similarities and advantageously reduces the weights of mismatches. The template matching method encompasses spatial Hough transform and sum of squared differences (SSD) minimization. SSD is efficiently approximated by exploiting the second-order derivative of image intensity. Experiments conducted on real-world data show the superiority of our methods.
Neural-like computing with populations of superparamagnetic basis\n functions (2016)

In neuroscience, population coding theory demonstrates that neural assemblies\ncan achieve fault-tolerant information processing. Mapped to nanoelectronics,\nthis strategy could allow for reliable computing with scaled-down, noisy,\nimperfect devices. Doing so requires that the population components form a set\nof basis functions in terms of their response functions to inputs, offering a\nphysical substrate for calculating. For this purpose, the responses of the\nnanodevices should be non-linear, and each tuned to different values of the\ninput. These strong requirements have prevented a demonstration of population\ncoding with nanodevices. Here, we show that nanoscale magnetic tunnel junctions\ncan be assembled to meet these requirements. We demonstrate experimentally that\na population of nine junctions can implement a basis set of functions,\nproviding the data to achieve, for example, the generation of cursive letters.\nWe design hybrid magnetic-CMOS systems based on interlinked populations of\njunctions and show that they can learn to realize non-linear\nvariability-resilient transformations with a low imprint area and low power.\n
Conformational Preferences of a Chimeric Peptide HIV-1 Immunogen from the C4−V3 Domains of gp120 Envelope Protein of HIV-1 CAN0A Based on Solution NMR:  Comparison to a Related Immunogenic Peptide from HIV-1 RF (1996)

A critical problem to overcome on HIV vaccine design is the variability among HIV strains. One strategy to solve this problem is the construction of multicomponent immunogens reflective of common HIV motifs. Currently, it is not known if these motifs should be based primarily on amino acid sequence or higher-order structure of the viral proteins of a combination of the two. In this paper, we report NMR-derived solution conformations for a sympathetic peptide taken from the C4 and V3 domains of HIV-1 CAN0A gp120 envelope protein. This peptide, designated T1-SP10CAN0(A), is compared to a recently reported C4-V3 peptide. T1-SP10RF(A) from the HIV-1 RF strain [de Lorimier et al. (1994) Biochemistry 33, 2055-2062], in terms of conformational features and immune responses in mice [Haynes et al. (1995) AIDS Res. Hum. Retroviruses 11, 211-221]. The T1 segment of 16 amino acids from the gp120 C4 domain is identical in both peptides and exhibits nascent helical character. The SP10 region, taken from the gp120 V3 loop, differs from that of T1-SP10RF(A) in both sequence and conformations. A reverse turn is observed at the conserved GPGX sequence. The rest of the Sp10 domain is extended with the exception of the last three residues which show evidence for a helical arrangement. Modeling of the turn region of the T1-SP10CAN0(A) peptide shows exposure of a continuous apolar stretch of side chains similar to that reported in the crystal structure of a V3 peptide from HIV-1 MN complexed with a monoclonal antibody [Rini et al. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 6325-6329]. this hydrophobic patch is interrupted by a charged Lys residue in the T1-SP10RF(A) peptide. This observation suggests that the HIV-1 CAN0A and HIV-1 RF C4-V3 peptides can induce widely different anti-HIV antibodies. consistent with immunogenic results.
Variable Step Size Maximum Power Point Tracker Using a Single Variable for Stand-alone Battery Storage PV Systems (2011)

The subject of variable step size maximum power point tracking (MPPT) algorithms has been addressed in the literature. However, most of the addressed algorithms tune the variable step size according to two variables: the photovoltaic (PV) array voltage (<TEX>$V_{PV}$</TEX>) and the PV array current (<TEX>$I_{PV}$</TEX>). Therefore, both the PV array current and voltage have to be measured. Recently, maximum power point trackers that arc based on a single variable (<TEX>$I_{PV}$</TEX> or <TEX>$V_{PV}$</TEX>) have received a great deal of attention due to their simplicity and ease of implementation, when compared to other tracking techniques. In this paper, two methods have been proposed to design a variable step size MPPT algorithm using only a single current sensor for stand-alone battery storage PV systems. These methods utilize only the relationship between the PV array measured current and the converter duty cycle (D) to automatically adapt the step change in the duty cycle to reach the maximum power point (MPP) of the PV array. Detailed analyses and flowcharts of the proposed methods are included. Moreover, a comparison has been made between the proposed methods to investigate their performance in the transient and steady states. Finally, experimental results with field programmable gate arrays (FPGAs) are presented to verify the performance of the proposed methods.
VSPDT: An Optimizer for Single Point Diamond Turning (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Interoperable PKI Data Distribution in Computational Grids (2009)

One of the most successful working examples of virtual organizations, computational grids need authentication mechanisms that inter-operate across domain boundaries. Public Key Infrastructures (PKIs) provide sufficient flexibility to allow resource managers to securely grant access to their systems in such distributed environments. However, as PKIs grow and services are added to enhance both security and usability, users and applications must struggle to discover available resources-particularly when the Certification Authority (CA) is alien to the relying party. This article presents how to overcome these limitations of the current grid authentication model by integrating the PKI Resource Query Protocol (PRQP) into the Grid Security Infrastructure (GSI).
757 M9657, a novel tumor-targeted conditional anti-CD137 agonist displays MSLN-dependent anti-tumor immunity (2021)

<h3>Background</h3> The costimulatory receptor CD137 (also known as 4-1BB and TNFRSF9) plays an important role in sustaining effective cytotoxic T cell immune responses and its agonism has been investigated as a cancer immunotherapy. In clinical trials, the systemic administration of the 1st generation CD137 agonist monotherapies, utomilumab and urelumab, were suspended due to either low anti-tumor efficacy or hepatotoxicity mediated by recognized epitope on CD137 and FcγR ligand-dependent clustering. <h3>Methods</h3> M9657, a bispecific antibody was engineered a tetravalent bispecific antibody (mAb2) format with the Fab portion binding to the tumor antigen Mesothelin (MSLN) and a modified CH2-CH3 domain as Fc antigen binding (Fcab) portion binding to CD137. M9657 has a human IgG1 backbone with LALA mutations to abrogate the binding to Fcγ receptor. The biological characteristics and activities of M9657 were investigated in a series of in vitro assays and the in vivo efficacy was investigated in syngeneic tumor models with FS122m, a murine-reactive surrogate with the same protein structure of M9657. <h3>Results</h3> M9657 binds efficiently to both human and Cynomolgus CD137 as well as MSLN. In the cellular functional assay, M9657 displayed MSLN- and TCR/CD3 interaction (signal 1)-dependent cytokine release and tumor cell cytotoxicity associated with Bcl-XL activation and immune memory formation. FS122m demonstrated potent MSLN- and dose- dependent in vivo anti-tumor efficacy (figure 1). Comparing with 3H3, a Urelumab surrogate Ab, FS122m displayed an improved therapeutic window with significantly lower for on-target /off-tumor toxicity. <h3>Conclusions</h3> Taken together, M9657 exhibits a promising developability profile as a tumor-targeted immune agonist with potent anti-cancer activity, but without systemic immune activation. <h3>Ethics Approval</h3> All animal experiments were performed in accordance with EMD Serono Research &amp; Development Institute (protocol 17-008, 20-005) and Wuxi AppTec Animal Care and Use Committee (IACUC) guidelines.
Molecular Characterization of the Genes pcaG and pcaH , Encoding Protocatechuate 3,4-Dioxygenase, Which Are Essential for Vanillin Catabolism in Pseudomonas sp. Strain HR199 (1999)

Pseudomonas sp. strain HR199 is able to utilize eugenol (4-allyl-2-methoxyphenol), vanillin (4-hydroxy-3-methoxybenzaldehyde), or protocatechuate as the sole carbon source for growth. Mutants of this strain which were impaired in the catabolism of vanillin but retained the ability to utilize eugenol or protocatechuate were obtained after nitrosoguanidine mutagenesis. One mutant (SK6169) was used as recipient of a Pseudomonas sp. strain HR199 genomic library in cosmid pVK100, and phenotypic complementation was achieved with a 5.8-kbp EcoRI fragment (E58). The amino acid sequences deduced from two corresponding open reading frames (ORF) identified on E58 revealed high degrees of homology to pcaG and pcaH, encoding the two subunits of protocatechuate 3,4-dioxygenase. Three additional ORF most probably encoded a 4-hydroxybenzoate 3-hydroxylase (PobA) and two putative regulatory proteins, which exhibited homology to PcaQ of Agrobacterium tumefaciens and PobR of Pseudomonas aeruginosa, respectively. Since mutant SK6169 was also complemented by a subfragment of E58 that harbored only pcaH, this mutant was most probably lacking a functional beta subunit of the protocatechuate 3, 4-dioxygenase. Since this mutant was still able to grow on protocatechuate and lacked protocatechuate 4,5-dioxygenase and protocatechuate 2,3-dioxygenase, the degradation had to be catalyzed by different enzymes. Two other mutants (SK6184 and SK6190), which were also impaired in the catabolism of vanillin, were not complemented by fragment E58. Since these mutants accumulated 3-carboxy muconolactone during cultivation on eugenol, they most probably exhibited a defect in a step of the catabolic pathway following the ortho cleavage. Moreover, in these mutants cyclization of 3-carboxymuconic acid seems to occur by a syn absolute stereochemical course, which is normally only observed for cis, cis-muconate lactonization in pseudomonads. In conclusion, vanillin is degraded through the ortho-cleavage pathway in Pseudomonas sp. strain HR199 whereas protocatechuate could also be metabolized via a different pathway in the mutants.
State-to-state dynamics of the Cl+CH3OH→HCl+CH2OH reaction (2004)

Molecular chlorine, methanol, and helium are co-expanded into a vacuum chamber using a custom designed "late-mixing" nozzle. The title reaction is initiated by photolysis of Cl2 at 355 nm, which generates monoenergetic Cl atoms that react with CH3OH at a collision energy of 1960 +/- 170 cm(-1) (0.24 +/- 0.02 eV). Rovibrational state distributions of the nascent HCl products are obtained via 2 + 1 resonance enhanced multiphoton ionization, center-of-mass scattering distributions are measured by the core-extraction technique, and the average internal energy of the CH3OH co-products is deduced by measuring the spatial anisotropy of the HCl products. The majority (84 +/- 7%) of the HCl reaction products are formed in HCl(v = 0) with an average rotational energy of [Erot] = 390 +/- 70 cm(-1). The remaining 16 +/- 7% are formed in HCl(v = 1) and have an average rotational energy of [Erot] = 190 +/- 30 cm(-1). The HCl(v = 1) products are primarily forward scattered, and they are formed in coincidence with CH2OH products that have little internal energy. In contrast, the HCl(v = 0) products are formed in coincidence with CH2OH products that have significant internal energy. These results indicate that two or more different mechanisms are responsible for the dynamics in the Cl + CH3OH reaction. We suggest that (1) the HCl(v = 1) products are formed primarily from collisions at high impact parameter via a stripping mechanism in which the CH2OH co-products act as spectators, and (2) the HCl(v = 0) products are formed from collisions over a wide range of impact parameters, resulting in both a stripping mechanism and a rebound mechanism in which the CH2OH co-products are active participants. In all cases, the reaction of fast Cl atoms with CH3OH is with the hydrogen atoms on the methyl group, not the hydrogen on the hydroxyl group.
Musashi2 sustains the mixed-lineage leukemia–driven stem cell regulatory program (2015)

Leukemia stem cells (LSCs) are found in most aggressive myeloid diseases and contribute to therapeutic resistance. Leukemia cells exhibit a dysregulated developmental program as the result of genetic and epigenetic alterations. Overexpression of the RNA-binding protein Musashi2 (MSI2) has been previously shown to predict poor survival in leukemia. Here, we demonstrated that conditional deletion of Msi2 in the hematopoietic compartment results in delayed leukemogenesis, reduced disease burden, and a loss of LSC function in a murine leukemia model. Gene expression profiling of these Msi2-deficient animals revealed a loss of the hematopoietic/leukemic stem cell self-renewal program and an increase in the differentiation program. In acute myeloid leukemia patients, the presence of a gene signature that was similar to that observed in Msi2-deficent murine LSCs correlated with improved survival. We determined that MSI2 directly maintains the mixed-lineage leukemia (MLL) self-renewal program by interacting with and retaining efficient translation of Hoxa9, Myc, and Ikzf2 mRNAs. Moreover, depletion of MLL target Ikzf2 in LSCs reduced colony formation, decreased proliferation, and increased apoptosis. Our data provide evidence that MSI2 controls efficient translation of the oncogenic LSC self-renewal program and suggest MSI2 as a potential therapeutic target for myeloid leukemia.
Natural Phosphate and Potassium Fluoride Doped Natural Phosphate as New Catalysts for the Vilsmeir–Haack type Reaction (2006)

The catalytic activity of the inexpensive natural- or potassium fluoride doped phosphates as bases was evaluated in a Vilsmeier–Haack type reaction. High efficiency, in term of chemical yields and reaction rates was found in the preparation of 2-chlor-3-cyanopyridines starting from 2-propylidene-malonitriles.
The Addition Reaction of β-Keto Carboxylic Acids to Olefinic Compounds by the Use of Mn(III) Tris(2-pyridinecarboxylate) as an Oxidant (1989)

Abstract Intermolecular addition reactions of radical species generated from β-keto carboxylic acids to olefinic compounds such as a silyl enol ether, a ketene dithioacetal and an enamine proceed selectively by the use of manganese(III) tris(2-pyridinecarboxylate) as an oxidant.
Carbon Nanotube Electrode‐Based Perovskite–Silicon Tandem Solar Cells (2020)

Carbon nanotube electrode–laminated perovskite solar cells in combination with n‐type tunnel oxide–passivated contact silicon solar cells demonstrate a high power conversion efficiency (PCE) of 24.42% when stacked in tandem. This is compared with conventional indium tin oxide/MoO x ‐deposited perovskite solar cells which give an efficiency of 22.35% when stacked in the same four‐terminal tandem system. Despite higher transmittance of the carbon nanotube electrode than that of the indium tin oxide/MoO x in the infrared range, the carbon nanotube electrode‐laminated devices show lower transmittance in the same region due to the total internal reflection and scattering as evidenced by optical simulation. Yet, the exceptionally high PCE of the carbon nanotube electrode‐laminated semitransparent devices far exceeding than that of the indium tin oxide/MoO x ‐deposited semitransparent top cell outweighs the effect of the optical transparency. Four types of silicon solar cells are compared as the bottom subcells, and the n‐type tunnel oxide‐passivated contact silicon solar cells are the best choice mainly due to their high absorption in the long‐wavelength region. The obtained 24.42% efficiency is one of the high PCEs among the reported four‐terminal perovskite–silicon solar cells, and this article is the first demonstration of the carbon nanotube electrode application in tandem solar cells.
Nonuniform microstrip lines analysis using neural networks (2010)

A technique based on an artificial neural network is presented for determining the reflection and transmission characteristics of nonuniform microstrip lines. The width of the microstrip line is expressed as a truncated Fourier series, whose coefficients are combined with the analysis frequency and input to the neural network to determine the S <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sub> and S <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">21</sub> parameters. A multilayer perceptron with two hidden layers and resilient error backpropagation training is used in this work. It was trained with 180 randomly generated microstrip lines whose S-parameters were determined by a different technique. Then, 60 randomly generated microstrip lines were used for validation. The obtained neural network results are in excellent agreement with those obtained by full-wave simulation.
Pd-Catalyzed α-Arylation of Nitriles and Esters and γ-Arylation of Unsaturated Nitriles with TMPZnCl·LiCl (2011)

Using TMPZnCl·LiCl as a kinetically highly active base, nitriles and esters undergo a Pd-catalyzed α-arylation under mild conditions. Remarkably, in the case of α,β- or β,γ-unsaturated nitriles, a regioselective γ-arylation or a γ-alkenylation is observed.
Effect of dipoles on carrier drift and diffusion of molecularly doped polymers (1997)

Drift mobilities and diffusion coefficients of molecularly doped polymers, with dipole moment as a parameter, have been measured by fitting a theoretical equation to time-of-flight photocurrent transients. The slope of the logarithm of mobility vs the square root of electric field is proportional to the dipole moment squared. A similar relationship is observed for diffusion coefficients. We analyze the results using disorder formalism and estimate the dipolar contribution ${\ensuremath{\sigma}}_{d}$ to the width of the density of states. The constant of proportionality in the relation between ${\ensuremath{\sigma}}_{d}$ and the dipole moment squared coincides with the theoretical value given by the dipole trap model. This result provides an important demonstration of the validity of both the disorder formalism and the dipole trap model.
A GaAs MESFET 16*16 crosspoint switch at 1700 Mbits/sec (1988)

A GaAs MESFET 16x16 crosspoint switch has been fabricated on a 3-mm x 4-mm chip using a 1-μm super buffer logic (SBL) design containing approximately 10000 FETs and operating at 800 mW of power. A 99% confidence bit error rate (BER) better than 1*10/sup -3/ was obtained at 1.7 Gb/s rate using a 2/sup 7/ -1 pseudorandom NRZ (nonreturn-to-zero) sequence. The BER test was done on one path using a probe card. The chip has 255 out of 256 good crosspoints. The bad crosspoint was a repeating error from a mask defect. An advanced refractory-gate MESFET process was used to fabricate the chip. A lightly doped drain structure was used to reduce parasitic gate capacitance while maintaining acceptable source resistance, to reduce short-channel effects, to increase breakdown voltage compared to devices where the heavy source/drain implant is directly self-aligned to the gate edge.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>