gebhart/patrepeval huggingface dataset:
Editorial Comment (2016)

No AccessJournal of UrologyAdult Urology1 Feb 2017Editorial Comment Shreyas Joshi and Alexander Kutikov Shreyas JoshiShreyas Joshi More articles by this author and Alexander KutikovAlexander Kutikov More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.08.143AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial Comment." The Journal of Urology, 197(2), pp. 383–384 References 1 : Long-term functional outcomes after treatment for localized prostate cancer. N Engl J Med2013; 368: 436. Google Scholar 2 : Systematic review and meta-analysis of studies reporting urinary continence recovery after robot-assisted radical prostatectomy. Eur Urol2012; 62: 405. Google Scholar 3 : Active surveillance compared with initial treatment for men with low-risk prostate cancer: a decision analysis. JAMA2010; 304: 2373. Google Scholar © 2017 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 197Issue 2February 2017Page: 383-384 Advertisement Copyright & Permissions© 2017 by American Urological Association Education and Research, Inc.MetricsAuthor Information Shreyas Joshi More articles by this author Alexander Kutikov More articles by this author Expand All Advertisement PDF downloadLoading ...
Opaque Attribute Alignment (2012)

Ontology alignment describes a process of mapping ontological concepts, classes and attributes between different ontologies providing a way to achieve interoperability. While there has been considerable research in this area, most approaches that rely upon the alignment of attributes use labelbased string comparisons of property names. The ability to process opaque or non-interpreted attribute names is a necessary component of attribute alignment. We describe a new attribute alignment approach to support ontology alignment that uses the density estimation as a means for determining alignment among objects. Using the combination of similarity hashing, Kernel Density Estimation (KDE) and Cross entropy, we are able to show promising F-Measure scores using the standard Ontology Alignment Evaluation Initiative (OAEI) 2011 benchmark.
Single Particle Observation of SV40 VP1 Polyanion-Induced Assembly Shows That Substrate Size and Structure Modulate Capsid Geometry (2017)

Simian virus 40 capsid protein (VP1) is a unique system for studying substrate-dependent assembly of a nanoparticle. Here, we investigate a simplest case of this system where 12 VP1 pentamers and a single polyanion, e.g., RNA, form a T = 1 particle. To test the roles of polyanion substrate length and structure during assembly, we characterized the assembly products with size exclusion chromatography, transmission electron microscopy, and single-particle resistive-pulse sensing. We found that 500 and 600 nt RNAs had the optimal length and structure for assembly of uniform T = 1 particles. Longer 800 nt RNA, shorter 300 nt RNA, and a linear 600 unit poly(styrene sulfonate) (PSS) polyelectrolyte produced heterogeneous populations of products. This result was surprising as the 600mer PSS and 500-600 nt RNA have similar mass and charge. Like ssRNA, PSS also has a short 4 nm persistence length, but unlike RNA, PSS lacks a compact tertiary structure. These data indicate that even for flexible substrates, shape as well as size affect assembly and are consistent with the hypothesis that work, derived from protein-protein and protein-substrate interactions, is used to compact the substrate.
Performance Analysis of RIS-Assisted Source Mixed RF/FSO Relay Networks. (2020)

This letter proposes and evaluates the performance of reconfigurable intelligent surface (RIS)-assisted source multiuser mixed radio frequency (RF)/free space optical (FSO) relay network with opportunistic user scheduling. Closed-form analytical approximations are derived for the outage probability and average symbol error probability (ASEP) assuming Rayleigh and Gamma-Gamma fading models for the RF and FSO channels, respectively. Moreover, to gain more insight into the system behavior, the system is studied at the high signal-to-noise ratio (SNR) regime whereby the diversity order and coding gain are derived and analyzed. The results illustrate that the system performance is dominated by the worst hop and that the diversity order is equal to Gd = min(KN,alpha,beta,zeta^2), where K is the number of RF users, N is the number of reflecting elements at each user, alpha and beta are the atmospheric turbulence parameters of the FSO link, and zeta^2 is a measure for the alignment quality of the FSO link. In addition, findings show that for the same diversity order, N is more impactful on the system performance than K through the coding gain Gc.
Modulating Target Protein Biology Through the Re-mapping of Conformational Distributions Using Small Molecules (2021)

Over the last 10 years considerable progress has been made in the application of small molecules to modulating protein-protein interactions (PPIs), and the navigation from "undruggable" to a host of candidate molecules in clinical trials has been well-charted in recent, comprehensive reviews. Structure-based design has played an important role in this scientific journey, with three dimensional structures guiding medicinal chemistry efforts. However, the importance of two additional dimensions: movement and time is only now being realised, as increasing computing power, closely aligned with wet lab validation, is applied to the challenge. Protein dynamics are fundamental to biology and disease, and application to PPI drug discovery has massively widened the scope for new chemical entities to influence function from allosteric, and previously unreported, sites. In this forward-looking perspective we highlight exciting, new opportunities for small molecules to modulate disease biology, by adjusting the frequency profile of natural conformational sampling, through the stabilisation of clinically desired conformers of target proteins.
The Multipole Resonance Probe: Progression and Evaluation of a Process Compatible Plasma Sensor (2014)

A robust and sensitive plasma sensor, the multipole resonance probe (MRP), and its process compatibility are presented and discussed in this paper. Based on its innovative concept and simple model describing the system “probe-plasma”, three steps of development are introduced. 3D electromagnetic field simulations are applied as an indispensable tool for an economical and efficient investigation and optimization of different sensor layouts. Independent of the chosen sensor design, a developed pulse-based measurement device yields an economical signal generation and evaluation. Electron density profiles, determined with the MRP and the pulse-based system utilized in a capacitive coupled plasma, confirm and demonstrate the simulation results and the measurement concept, respectively.
ChemInform Abstract: PRACTICAL METHOD FOR α‐ALKENYL KETONE SYNTHESIS BASED ON A FACILE REDUCTIVE REARRANGEMENT OF ALKYNYL HALOHYDRINS (1983)

Abstract Nach einer neuen Methode werden die bisher schwierig zugänglichen α‐Alkenylalkohole (IV), (VII), (X), (XIII), (XVI) und (XIX) dargestellt sowie als weiteresAnwendungsbeispiel das makrocyclische Keton (XXIV).
Case 7 (2013)

Case presentations focus on mapping techniques, diagnosis, and proper catheter placement for successful ablation of arrhythmias. This case focuses on ventricular extrastimulation testing, failure to sense, Brugada syndrome, and sudden unexplained death syndrome.
Burst photography for high dynamic range and low-light imaging on mobile cameras (2016)

Cell phone cameras have small apertures, which limits the number of photons they can gather, leading to noisy images in low light. They also have small sensor pixels, which limits the number of electrons each pixel can store, leading to limited dynamic range. We describe a computational photography pipeline that captures, aligns, and merges a burst of frames to reduce noise and increase dynamic range. Our system has several key features that help make it robust and efficient. First, we do not use bracketed exposures. Instead, we capture frames of constant exposure, which makes alignment more robust, and we set this exposure low enough to avoid blowing out highlights. The resulting merged image has clean shadows and high bit depth, allowing us to apply standard HDR tone mapping methods. Second, we begin from Bayer raw frames rather than the demosaicked RGB (or YUV) frames produced by hardware Image Signal Processors (ISPs) common on mobile platforms. This gives us more bits per pixel and allows us to circumvent the ISP's unwanted tone mapping and spatial denoising. Third, we use a novel FFT-based alignment algorithm and a hybrid 2D/3D Wiener filter to denoise and merge the frames in a burst. Our implementation is built atop Android's Camera2 API, which provides per-frame camera control and access to raw imagery, and is written in the Halide domain-specific language (DSL). It runs in 4 seconds on device (for a 12 Mpix image), requires no user intervention, and ships on several mass-produced cell phones.
Synthesis of (alkoxymethyl)zirconocene chlorides: stereochemistry of carbon-carbon bond formation in a zirconocene-Wittig rearrangement (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of (alkoxymethyl)zirconocene chlorides: stereochemistry of carbon-carbon bond formation in a zirconocene-Wittig rearrangementStephen L. Buchwald, Ralph B. Nielsen, and John C. DewanCite this: Organometallics 1989, 8, 7, 1593–1598Publication Date (Print):July 1, 1989Publication History Published online1 May 2002Published inissue 1 July 1989https://pubs.acs.org/doi/10.1021/om00109a002https://doi.org/10.1021/om00109a002research-articleACS PublicationsRequest reuse permissionsArticle Views690Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Sharply directed emission in organic electroluminescent diodes with an optical-microcavity structure (1994)

An optical microcavity structure was introduced into organic three-layer electroluminescent (EL) diodes with a europium complex as an emission layer. The device structure consisted of a dielectric reflector composed of SiO2/TiO2 bilayers, an indium-tin-oxide electrode, a hole transport layer, a europium complex as an emission layer, an electron transport layer, and a MgAg electrode. The dielectric reflector and the MgAg metal electrode constituted a planer microcavity. Sharply directed emission from the europium complex was observed when operated under dc drive voltage. Both angular dependences of intensity of emitted light and emission spectra of the EL diodes with the microcavity were compared with those of conventional EL diodes without microcavity.
Circulating proteome for pulmonary nodule malignancy (2023)

Circulating protein markers can help differentiate malignant from benign pulmonary nodules. Validation with an independent computed tomographic screening study will be required before clinical implementation.
Changes in the strength of co-stimulation through the B7/CD28 pathway alter functional T cell responses to altered peptide ligands (1999)

T cells require a TCR and a co-stimulatory signal for activation. We have examined the effect of the strength of TCR and co-stimulatory signals on proliferation and production of cytokines by differentiated T cell clones. The TCR signal was varied using antigen dose and altered peptide ligands. The co-stimulatory signal was varied by using as antigen-presenting cells, Chinese hamster ovary cell transfectants that express different levels of the B7-1 molecule with similar levels of MHC class II. Our results show that the level of co-stimulation has a profound effect on the response to an antigen, and that a strong co-stimulatory signal can convert a weak agonist into a full agonist and an agonist into a superagonist. Antigenicity is not absolute but a function of the strengths of the TCR and co-stimulatory signals. Increasing the strength of co-stimulation can lower antigen concentration required for maximal proliferative responses by T cell clones by 5 log. These results show that the level of expression of co-stimulatory molecules will profoundly regulate T cell clonal expansion and effector functions.
Endosonography-guided, fine-needle aspiration cytology extending the indication for organ-preserving pancreatic surgery (2000)

Organ preserving pancreatic resections are considered whenever malignant disease is ruled out. In tumors of low malignant potential such as cystadenomas and neuroendocrine tumors, the diagnosis is rarely established preoperatively. We studied the feasibility of cytodiagnosis using endosonography-guided fine-needle aspiration in determining the operative approach.A total of 78 patients (16 female, 62 male; mean age 61.4 yr, range 31-82 yr) with focal pancreatic lesions underwent EUS-FNA. Final diagnosis was confirmed by histology, cytology, or clinical follow up (>9 months). Patients with tumors of low malignant potential were managed by customized pancreatic resections.Final diagnosis was malignant tumors in 36 patients, tumors of low malignant potential in nine (six, neuroendocrine, two, borderline mucinous cystadenomas, one, borderline adenocarcinoma), and benign in 31 (two inadequate smears). No complications occurred. With six false-negative and no false-positive results, the accuracy, sensitivity, specificity, and positive and negative predictive values were 92%, 84%, 100%, 100%, and 86%, respectively. Five patients with low malignant tumors underwent duodenum-preserving pancreatic head resection, three mid segment resection, and one pylorus-preserving pancreatoduodenectomy.EUS-FNA is useful in the preoperative cytodiagnosis of pancreatic tumors of low malignant potential. It extends the indication for organ-preserving pancreatic resections and avoids the unnecessary sacrifice of adjacent organs.
Plasticity of Hepatic Cell Differentiation: Bipotential Adult Mouse Liver Clonal Cell Lines Competent to Differentiate In Vitro and In Vivo (2006)

In fetal liver, bipotential hepatoblasts differentiate into hepatocytes and bile duct cells (cholangiocytes). The persistence of such progenitor cells in adult mouse liver is still debated. In damaged liver of adult murine animals, when hepatocyte proliferation is compromised, bipotential oval cells emerge, probably from bile ducts, proliferate, and differentiate to regenerate the liver. However, treatment to elicit oval cell proliferation is not necessary to obtain bipotential stem cells from adult mouse liver. Here, we have isolated bipotential clonal cell lines from healthy liver of 8-10-week-old C57BL/6 mice. Primary cultures established from hepatocyte-enriched suspensions were characterized by time-lapse image acquisition, immunocytology, and RNA transcript analysis. Although hepatocytes dedifferentiated with loss of apical polarity and other hepatocyte markers, they rapidly activated expression of bile duct/oval cell markers. Reversibility of these processes was achieved in part by culture under dilute Matrigel or by aging of confluent cultures. Cell lines were obtained at high frequency from mass cultures, from isolated colonies, and by primary cloning of the hepatocyte-enriched suspension. Cells of the clonal cell lines do not grow in soft agar and are nontumorigenic, and they express cytokeratin 19, A6 antigen, and alpha6 integrin, as well as a large panel of hepatocyte functions. Furthermore, they can participate in liver regeneration in albumin-urokinase-type plasminogen activator/severe combined immune-deficient mice, where they differentiate in clusters of hepatocytes and occasionally bile ducts. These results demonstrate the existence, in normal adult mouse liver, of a significant pool of clonogenic cells that are (or can become) bipotential.
Linear microbolometer arrays for space and terrestrial imaging (2006)

Linear detector array formats are suitable for applications where relative motion between the detector and scene provides an intrinsic scanning mechanism, such as industrial inspection systems and satellite-based earth and planetary observation. The linear array format facilitates the introduction readout features not available in 2-D formats and when combined with low cost packaging approaches reduces sensor cost. We present two linear uncooled detector arrays based on VO<sub>x</sub> microbolometer technology and integrated CMOS readout electronics. The IRL256B is a linear array of 256 detectors on a 52 &#956;m pitch. It includes a parallel array of 256 reference detectors to provide coarse offset correction and substrate temperature drift compensation. The IRL512A consists of 3 parallel lines of 512 pixels on a 39 &#956;m pitch. It is particularly well suited to multi-spectral pushbroom imaging applications. Each pixel includes active and reference detectors to reduce pixel offset, eliminate common mode power supply noise and increase immunity to chip temperature drift. All pixels are integrated in parallel and the data are output in 14-bit digital format on three parallel output buses. The microbolometer detector design can be customized for selected wavelength ranges from NIR to VLWIR. The IRL256B has been integrated in industrial thermal line-scan imagers and spectrometers and may also be employed in uncooled airborne imaging and scanned surveillance or inspection systems. The IRL512A has been selected as the baseline detector for a number of future earth observation satellite missions.
Wavelet Meets Actogram (2013)

A variety of methods to determine phase markers and period length from experimental data sets have traditionally assumed a rhythm of fixed period and amplitude. But most biological oscillations exhibit fluctuations in both period and amplitude, leading to the recent interest in the application of wavelet transforms that can measure how rhythms vary over time. Here we examine how wavelet-based methods can be extended to the analysis of conventional actograms, including the detection of onsets in circadian activity and temperature rhythms of rodents.
Quasi‐lumped bandpass filter with sharp transition edge and wide stopband rejection (2013)

Presented is a highly miniaturised bandpass filter (BPF) with superior passband selectivity and high rejection over a wide stopband for 2.4 GHz WLAN applications. The proposed third‐order coupled resonator design with a cross‐coupled path provides an attenuation pole that is very close to the passband. Properly setting the fractional bandwidth and the resonator Q factor yields a sharp transition edge to suppress a 2.1 GHz WCDMA signal. Furthermore, the use of quasi‐lumped LC resonators reduces the area of the BPF and generates multiple transmission zeros to enhance the desired stopband rejection.
Cross-Sectional Survey of Physicians on Providing Volunteer Care for In-Flight Medical Events (2017)

Many physicians lack basic knowledge about IFMEs. Responders may assist more effectively if better informed about protocols and the availability of ground medical support. Education and timely information support are recommended.Chatfield E, Bond WF, McCay B, Thibeault C, Alves PM, Squillante M, Timpe J, Cook CJ, Bertino RE. Cross-Sectional Survey of Physicians on Providing Volunteer Care for In-Flight Medical Events. Aerosp Med Hum Perform. 2017; 88(9):876-879.
Do the Current Landscape Evolution Models Show Self‐Organized Criticality? (1996)

In this note we question the relevance of the self‐organized criticality concept as currently applied to landscape evolution modeling. We also express concerns about possible inference problems in testing hypotheses about landscape multifractality using simulated landscapes.
Preparation and characterization of SrBi2Ta2O9 thin films by low‐oxygen‐concentration annealing technique (1999)

SrBi2Ta2O9 thin films were successfully prepared at a low annealing temperature using a low-oxygen-concentration annealing technique. It was possible to obtain a single perovskite phase at 600 °C in 0.7% oxygen concentration and fluorite phase was observed at 600 °C in 100% oxygen. In addition, the SrBi2Ta2O9 thin films annealed at 650 °C in 0.7% oxygen were well crystallized and composed of dense crystal grains with a size of 70 nm. The remanent polarization and leakage current density of the SrBi2Ta2O9 thin film obtained using this new technique were 7 μC/cm2 and 3 × 10−9 A/cm2 (at 5 V), respectively. The final remanent polarization after 109 switching cycles was nearly constant. © 1999 Scripta Technica, Electr Eng Jpn, 129(4): 1–6, 1999
High external quantum efficiency and fill-factor InGaN/GaN heterojunction solar cells grown by NH3-based molecular beam epitaxy (2011)

High external quantum efficiency (EQE) p-i-n heterojunction solar cells grown by NH3-based molecular beam epitaxy are presented. EQE values including optical losses are greater than 50% with fill-factors over 72% when illuminated with a 1 sun AM0 spectrum. Optical absorption measurements in conjunction with EQE measurements indicate an internal quantum efficiency greater than 90% for the InGaN absorbing layer. By adjusting the thickness of the top p-type GaN window contact layer, it is shown that the short-wavelength (&amp;lt;365 nm) quantum efficiency is limited by the minority carrier diffusion length in highly Mg-doped p-GaN.
Periostin antisense oligonucleotide suppresses bleomycin‐induced formation of a lung premetastatic niche for melanoma (2018)

Metastasis is the leading cause of cancer death. A tumor-supportive microenvironment, or premetastatic niche, at potential secondary tumor sites plays an important role in metastasis, especially in tumor cell colonization. Although a fibrotic milieu is known to promote tumorigenesis and metastasis, the underlying molecular contributors to this effect have remained unclear. Here we show that periostin, a component of the extracellular matrix that functions in tissue remodeling, has a key role in formation of a fibrotic environment that promotes tumor metastatic colonization. We found that periostin was widely expressed in fibrotic lesions of mice with bleomycin-induced lung fibrosis, and that up-regulation of periostin expression coincided with activation of myofibroblasts positive for α-smooth muscle actin. We established a lung metastasis model for B16 murine melanoma cells and showed that metastatic colonization of the lung by these cells was markedly promoted by bleomycin-induced lung fibrosis. Inhibition of periostin expression by giving an intratracheal antisense oligonucleotide targeting periostin mRNA was found to suppress bleomycin-induced lung fibrosis and thereby to attenuate metastatic colonization of the lung by melanoma cells. Our results indicate that periostin is a key player in the development of bleomycin-induced fibrosis and consequent enhancement of tumor cell colonization in the lung. Our results therefore implicate periostin as a potential target for prevention or treatment of lung metastasis.