gebhart/patrepeval huggingface dataset:
Hyperacute Stroke: Simultaneous Measurement of Relative Cerebral Blood Volume, Relative Cerebral Blood Flow, and Mean Tissue Transit Time (1999)

MR imaging can delineate areas of altered blood flow, blood volume, and water mobility in hyperacute human stroke. Predictive models of tissue outcome may benefit by including computation of both relative cerebral blood flow and blood volume.
SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats (2009)

Hepatic gluconeogenesis is a major contributing factor to hyperglycemia in the fasting and postprandial states in type 2 diabetes mellitus (T2DM). Because Sirtuin 1 (SirT1) induces hepatic gluconeogenesis during fasting through the induction of phosphoenolpyruvate carboxylase kinase (PEPCK), fructose-1,6-bisphosphatase (FBPase), and glucose-6-phosphatase (G6Pase) gene transcription, we hypothesized that reducing SirT1, by using an antisense oligonucleotide (ASO), would decrease fasting hyperglycemia in a rat model of T2DM. SirT1 ASO lowered both fasting glucose concentration and hepatic glucose production in the T2DM rat model. Whole body insulin sensitivity was also increased in the SirT1 ASO treated rats as reflected by a 25% increase in the glucose infusion rate required to maintain euglycemia during the hyperinsulinemic-euglycemic clamp and could entirely be attributed to increased suppression of hepatic glucose production by insulin. The reduction in basal and clamped rates of glucose production could in turn be attributed to decreased expression of PEPCK, FBPase, and G6Pase due to increased acetylation of signal transducer and activator of transcription 3 (STAT3), forkhead box O1 (FOXO1), and peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha), known substrates of SirT1. In addition to the effects on glucose metabolism, SirT1 ASO decreased plasma total cholesterol, which was attributed to increased cholesterol uptake and export from the liver. These results indicate that inhibition of hepatic SirT1 may be an attractive approach for treatment of T2DM.
Small-Form-Factor All-InP Integrated Laser Vector Modulator Enables the Generation and Transmission of 256-Gb/s PDM-16QAM Modulation Format (2013)

We demonstrate, using a compact InP-based integrated assembly of a tunable laser and a double-nested Mach-Zehnder modulator, generation of Nyquist-prefiltered QPSK and 16-QAM signals at 32-Gbaud. We transmitted them over 8000-km and 960-km SSMF, respectively.
Appendix A: Various Diagnostic Strategies for Automating Process Fault Analysis (2012)

This appendix contains sections titled: Introduction Fault Tree Analysis Alarm Analysis Decision Tables Sign-Directed Graphs Diagnostic Strategies Based on Qualitative Models Diagnostic Strategies Based on Quantitative Models Artificial Neural Network Strategies Knowledge-Based System Strategies Methodology Choice Conclusions References
Secrecy Analysis for MISO Broadcast Systems with Regularized Zero-Forcing Precoding (2023)

As an effective way to enhance the physical layer security (PLS) for the broadcast channel (BC), regularized zero-forcing (RZF) precoding has attracted much attention. However, the reliability performance, i.e., secrecy outage probability (SOP), of RZF is not well investigated in the literature. In this paper, we characterize the secrecy performance of RZF precoding in the large multiple-input single-output (MISO) broadcast system. For this purpose, we first consider a central limit theorem (CLT) for the joint distribution of the users' signal-to-interference-plus-noise ratio (SINR) and the eavesdropper's (Eve's) signal-to-noise ratio (ESNR) by leveraging random matrix theory (RMT). The result is then utilized to obtain a closed-form approximation for the ergodic secrecy rate (ESR) and SOP of three typical scenarios: the case with only external Eves, the case with only internal Eves, and that with both. The derived results are then used to evaluate the percentage of users in secrecy outage and the required number of transmit antennas to achieve a positive secrecy rate. It is shown that, with equally-capable Eves, the secrecy loss caused by external Eves is higher than that caused by internal Eves. Numerical simulations validate the accuracy of the theoretical results.
Hybrid feature selection methods for online biomedical publication classification (2015)

We review several feature selection methods: Recursive Feature Elimination, Select K Best, and Random Forests, as elements of a processing chain for feature selection in a text mining task. The text mining task is a multi-label classification problem of label assignment; metadata that is usually applied to published scientific papers by expert curators. In the formulation of this classification task, a feature space that is dramatically larger than the available training data occurs naturally and inevitably. We explore ways to reduce the dimension of the feature space, and show that sequential feature selection does substantially improve performance for this complex type of data.
Alcohol Adducts of N-Heterocyclic Carbenes:  Latent Catalysts for the Thermally-Controlled Living Polymerization of Cyclic Esters (2006)

Alcohol adducts of the N-heterocyclic carbene, 1,3,4-triphenyl-4,5-dihydro-1H-1,2-triazol-5-ylidene (NHC), function as excellent single-component catalyst/initiators for the ring-opening polymerization of lactide and β-butyrolactone. Their reversible dissociation at elevated temperatures generates alcohol and triazolylidene carbene to provide a facile entry to polymerization of cyclic esters on demand. Under optimum conditions, adverse transesterification reactions are minimized, and importantly, upon complete consumption of monomer, a second monomer addition facilitates additional polymer growth, even after precipitation. Block copolymers were prepared by combining disparate polymerization techniques from the use of oligo-adducts and bifunctional initiators. Additionally, more complex polymer architectures were prepared from multifunctional or dendritic initiators, further demonstrating the versatility of the N-heterocyclic carbene platform.
Anti-Site Defects in Perovskite YAlO3:Ce Using Aberration-Corrected STEM (2014)

The aluminate perovskites YAlO 3 have been identified as potential scintillator materials due to their high light output and short decay time. However, the performance of YAlO 3 is still low. Despite the promising optical properties of YAlO 3 , it has been proposed that their potential as scintillators has not been fully realized Recently, the focus has been on carrier traps as the limiting factor in the performance of YAlO 3 , but the nature of these traps has not been identified. An investigation using firstprinciples calculations suggested that anti-site defects in which B-site Aluminum and A-site Yttrium are interchanged have a lower energy than Shottky or Frenkel defects Despite numerous studies, there is still no direct evidence to show the existence of anti-site defects.
Transmit Antenna Selection in MIMO-OFDM Systems: Bulk Versus Per-Tone Selection (2008)

This paper provides an exact diversity gain analysis for transmit antenna selection in MIMO-OFDM systems with linear receivers, a topic scarcely addressed in prior literature. In a frequency-selective fading (as opposed to a frequency-flat fading) channel one of either two methods of antenna selection may be applied. We name these methods bulk selection and per-tone selection. From an implementation perspective each method presents a different complexity-performance tradeoff. Through rigorous mathematical derivation, we demonstrate that both methods realize the same diversity order. Moreover, the coding gain realized by the two selection methods is also analyzed and compared through simulation. Overall, this paper confirms the advantage of antenna selection technology in MIMO-OFDM systems, and provides comprehensive guidelines for antenna selection strategies in realistic scenarios, from both the performance and complexity perspectives.
Surface morphology of spin‐coated molecularly imprinted polymer films (2009)

Abstract The surface morphology of thin molecularly imprinted polymer films has been studied using atomic force microscopy (AFM). The films were produced by spin coating onto glass substrates and examined as a function of host polymer, imprinting template, casting solvent, spin‐coater rotation speed and post‐production treatment. It was observed that the gross features of such films are template controlled. The fine structure is determined by parameters such as solvent, spin speed or subsequent treatment. The relationship between these observations, polymer–template interactions and the mechanism of film formation in spin coating is discussed. Copyright © 2009 John Wiley &amp; Sons, Ltd.
The Impact of National Culture on Strategic IT Alignment: A Multiple-case Study of Subsidiaries of Multinational Corporations (2021)

Through a multiple-case study of three subsidiaries of multinational corporations (MNCs), we examined the impact of national culture on strategic information technology (IT) alignment. We found that the headquarters and subsidiary host national cultures affect alignment indirectly, through variables in the organizational context, including intercultural communications, IT governance, management style, differences in work values and practices, and cultural conflict and mistrust. Based on the findings, we propose a model of national culture and alignment.
The Influence of Injection Strategy and Glow Plug Temperature on Cycle by Cycle Stability Under Cold Idling Conditions for a Low Compression Ratio, HPCR Diesel Engine (2012)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Experimental studies have been undertaken on a single-cylinder HPCR diesel engine with a compression ratio of 15.5:1 to explore the effect of fuel injection strategy on cycle by cycle stability. The influence of the number, separation and quantity of pilot injections on the coefficient of variation of IMEP has been investigated at -20°C, 1000 rev/min, post-start idling conditions. Injection strategy and glow plug temperature trade-off has also been investigated at a range of soak temperatures. Up to four pilot injections have been used. For timing of the main injection near to the optimum, CoV&lt;sub&gt;IMEP&lt;/sub&gt; values of 10% or better can be achieved. Closer spacing of injections improved stability and extended the range of timings to meet target stability. The best combinations of pilot number and pilot quantity varied with total fuel delivered. For a 20 mg/cycle total, twin-pilot injections delivering a total pilot fuel of 4 mg/cycle, or three or four delivering a total pilot fuel of 4 mg/cycle or 6 mg/cycle, gave best stability, but at lower total fuelling (16 mg/cycle) stability was not so good and achieved by fewer combinations.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;Target stability was not achieved through hotter glow plug temperatures alone; a multiple pilot strategy or an increase in total fuelling was necessary. Increasing the number of pilot injections and glow plug temperature produced a higher premix contribution and a following strong development of main combustion, which is generally consistent with better cycle by cycle stability. At high glow plug temperatures and using three and four pilot injections, stability improved with warmer soak temperatures. At -5°C, stability was particularly poor when single- or twin-pilot injections were used irrespective of glow plug temperature.&lt;/div&gt;&lt;/div&gt;
Antiviral effects of nisin, lysozyme, lactoferrin and their mixtures against bovine viral diarrhoea virus (2019)

The tested substances could be applied in bovine viral diarrhoea prevention and therapy, especially when used in combination.
Fluorescence-Based Ratiometric Analysis of Sperm Centrioles (FRAC) Finds Patient Age and Sperm Morphology Are Associated With Centriole Quality (2021)

A large proportion of infertility and miscarriage causes are unknown. One potential cause is a defective sperm centriole, a subcellular structure essential for sperm motility and embryonic development. Yet, the extent to which centriolar maladies contribute to male infertility is unknown due to the lack of a convenient way to assess centriole quality. We developed a robust, location-based, ratiometric assay to overcome this roadblock, the Fluorescence-based Ratiometric Assessment of Centrioles (FRAC). We performed a case series study with semen samples from 33 patients, separated using differential gradient centrifugation into higher-grade (pellet) and lower-grade (interface) sperm fractions. Using a reference population of higher-grade sperm from infertile men with morphologically standard sperm, we found that 79% of higher-grade sperm of infertile men with substandard sperm morphology have suboptimal centrioles (<i>P</i> = 0.0005). Moreover, tubulin labeling of the sperm distal centriole correlates negatively with age (<i>P</i> = 0.004, <i>R</i> = -0.66). These findings suggest that FRAC is a sensitive method and that patient age and sperm morphology are associated with centriole quality.
An inspiring introduction (2006)

Organic Photovoltaics provides a superb and comprehensive perspective on the basic concepts and latest research in this rapidly expanding field.
Regaining Rotatory Motion in the Forearm Following Injury and Immobilization (1977)

This data collection includes data collected as part of the project Selfbuilding: the production and consumption of new homes from the perspective of households. It includes (1) survey data with self builders and potential self builders, alongside (2) transcripts for interviews conducted with key informants (KI) and (3) transcripts for interviews conducted with self builders. (1) The survey data submitted here was collected in 2012-13 via two online surveys, generated and hosted by Bristol Online Surveys. PDF copies of these surveys are included as part of this submission. (a) The first of these targeted contemporary self builders--people who were building or who had built their own homes in the last 20 years. It consisted for 54 questions, covering the desire to selfbuild; past and present residential choice; experiences of construction and self-build; planning your selfbuild; financing your self-build; details of individual self-build projects; and experience of self-building; while also collecting basic information about individual households. (b) The second of these targeted would-be self builders. A much shorter survey, this was designed to merely capture a sense of what people wanted to achieve through self-build and their motivations alongside basic information. (2) The submission to the archive include 30 transcripts of semi-structured interviews conducted with key informants--industry professionals, housing practitioners, local authority representatives and planners. These were conducted between 2013 and 2015. (3) The submission also includes transcripts from in-depth interviews conducted with 22 research participants. Where follow-up visits including recorded interviews took place, there are additional transcripts. The self-building of homes is being promoted as one solution to the shortage of affordable houses in Britain. Currently, self-build projects account for 14% of the new homes built, a percentage equivalent to or greater than that of any single house building firm. This form of housing provision is, however, understudied, with the result that there is very little understanding of who the people are who choose to build their homes, the motivations for this residential practice and experiences of self-building. This project aims to correct this lacuna of knowledge, conducting a systematic enquiry into self-building in Britain, taking seriously the need to know who is using self-build, what their characteristics are and to what extent they succeed in their aims, as well as exploring how the self-build market is structured. The project will be conducted over three years, and is comprised of several different modes of data collection and analysis, engaging self-build households, potential self-builders, industry professionals and experts, national and local planning authorities. This will be supplemented with a review of planning and housing policies, and analysis of popular representations of self-build in Britain.
ChemInform Abstract: Synthesis of Peptide Libraries for Lead Structure Screening (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Block-Based Physical Modeling with Applications in Musical Acoustics (2008)

Block-Based Physical Modeling with Applications in Musical Acoustics Block-based physical modeling is a methodology for modeling physical systems with different subsystems. Each subsystem may be modeled according to a different paradigm. Connecting systems of diverse nature in the discrete-time domain requires a unified interconnection strategy. Such a strategy is provided by the well-known wave digital principle, which had been introduced initially for the design of digital filters. It serves as a starting point for the more general idea of block-based physical modeling, where arbitrary discrete-time state space representations can communicate via wave variables. An example in musical acoustics shows the application of block-based modeling to multidimensional physical systems.
Individual-specific levels of CTG•CAG somatic instability are shared across multiple tissues in myotonic dystrophy type 1 (2022)

Myotonic dystrophy type 1 is a complex disease caused by a genetically unstable CTG repeat expansion in the 3'-untranslated region of the DMPK gene. Age-dependent, tissue-specific somatic instability has confounded genotype-phenotype associations, but growing evidence suggests that it also contributes directly toward disease progression. Using a well-characterized clinical cohort of DM1 patients from Costa Rica, we quantified somatic instability in blood, buccal cells, skin and skeletal muscle. Whilst skeletal muscle showed the largest expansions, modal allele lengths in skin were also very large and frequently exceeded 2000 CTG repeats. Similarly, the degree of somatic expansion in blood, muscle and skin were associated with each other. Notably, we found that the degree of somatic expansion in skin was highly predictive of that in skeletal muscle. More importantly, we established that individuals whose repeat expanded more rapidly than expected in one tissue (after correction for progenitor allele length and age) also expanded more rapidly than expected in other tissues. We also provide evidence suggesting that individuals in whom the repeat expanded more rapidly than expected in skeletal muscle have an earlier age at onset than expected (after correction for the progenitor allele length). Pyrosequencing analyses of the genomic DNA flanking the CTG repeat revealed that the degree of methylation in muscle was well predicted by the muscle modal allele length and age, but that neither methylation of the flanking DNA nor levels of DMPK sense and anti-sense transcripts could obviously explain individual- or tissue-specific patterns of somatic instability.
Pack Transposition: Enhancing Superword Level Parallelism Exploitation. (2005)

Permission to make digital or hard copies of portions of this work for personal or classroom use is granted provided that the copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. To copy otherwise requires prior specific permission by the publisher mentioned above.
ChemInform Abstract: Unexpected Diversity in the Coordination Chemistry of Tartrate Esters with Titanium(IV). (1987)

Abstract A tartrate ester can display a remarkably wide range of binding modes in its coordination to titanium.
TĪNĒ: the fate, behavior, and ecotoxicology of manufactured nanomaterials in terrestrial ecosystems (2012)

We have developed a life cycle perspective&#13;\ninspired conceptual model (CM) that indicates terrestrial ecosystems&#13;\nas a major repository for ZnO, TiO2, and Ag manufactured nanomaterials&#13;\n(MNMs) introduced via the land application of MNM-containing biosolids.&#13;\nIn this project we are investigating the transport, fate, behavior, bioavailability,&#13;\nand effects of MNMs in(to) agroecosystems under environmentally&#13;\nrealistic scenarios organized around three key hypotheses: Hypothesis (H1) Surface chemistry is the primary factor influencing the fate and transport&#13;\nof MNMs in the terrestrial environment as well as the bioavailability&#13;\nand effects to biological receptors; Hypothesis (H2) Once released to the&#13;\nenvironment, pristine MNM surfaces will be modified by interactions with&#13;\norganic and inorganic ligands (macromolecules) or via other biogeochemical&#13;\ntransformations (aging effects forming a-MNMs); Hypothesis (H3)&#13;\nEcoreceptors will respond to interactions with pristine metal and metal&#13;\noxide MNMs, a-MNMs, and/or dissolved constituent metal ions and bulk&#13;\noxides by specific ecological and toxicogenomic responses that will reflect&#13;\ntheir combined effects. The overall objectives are to: O1) Compare the&#13;\ntransport, fate, behavior, bioavailability, and effects of MNMs, a- MNMs,&#13;\nand/or dissolved free metals/bulk oxides to organisms with key terrestrial&#13;\necosystem functions, as well as exposure pathways involving humans; O2)&#13;\nDetermine MNM, surface modified MNM and a-MNM interactions with&#13;\nimportant biological targets relevant to the BLM and pBRM models and&#13;\nrelate these interactions to physicochemical properties; O3) Validate models&#13;\nwith information generated from experiments designed to address O1 for&#13;\nMNMs introduced through a pilot scale Waste Water Treatment Process&#13;\n(WWTP) to key terrestrial ecoreceptors, including effects of MNMs on the&#13;\nWWTP itself; O4) Determine realistic MNM emission scenarios for Tier&#13;\n1 MNMs in wastewater from the WWT pilot plant data and develop first&#13;\ngeneration Life-Cycle-Analysis-inspired Risk Assessment (LCA-RA) model&#13;\ncomponents for terrestrial effects of Tier 1 MNMs and a-MNMS based&#13;\non data generated in experiments designed to address O1, O2, &amp; O3; and&#13;\nO5) Provide tools for in situ detection, monitoring, and characterization of&#13;\npristine MNMs and a-MNMs in environmental media and biota. The key&#13;\nresults from aging and toxicity studies will be presented.
ChemInform Abstract: A General Allylation Procedure Using Trimethylallylsilane and Fluoride Catalysis. (1986)

Abstract Die Allylierung von Michael‐Systemen mit dem Reagens Trimethylallylsilan (ID/Tributylammonium?uorid (III) in HMPA/DMF wird beschrieben.
X-ray reflectivity study of an oil-water interface in equilibrium with a middle-phase microemulsion (1994)

The roughness and surface correlations of a surfactant monolayer at an oil-water interface in equilibrium with a small amount of middle-phase microemulsion were studied using x-ray scattering. High energy x rays in conjunction with tight instrumental resolution allow us to separate and quantify the specular reflectivity and surface diffuse scattering of the interface. The experimental results are explained using a height-height correlation function derived from a capillary wave model. The interface was found to have an intrinsic roughness of 85 \AA{} and an interfacial tension of 0.11 dyn/cm.