gebhart/patrepeval huggingface dataset:
A wafer-level system integration technology for flexible pseudo-SOC incorporates MEMS-CMOS heterogeneous devices (2010)

A flexible pseudo-SoC which integrates electrostatic MEMS and its driver CMOS-LSI for mobile electronics device applications has been developed. From the experiments, the pseudo-SoC process has succeeded to form a fine-pitch on-chip global layer on the MEMS and CMOS-LSI embedded in the epoxy resin and to realize total thickness of 100 μm. This paper reports the pseudo-SoC that overcomes the limitation of system integration and provides the complementary advantages of SiP and SoC within the results of a highly-integrated flexible pseudo-SoC incorporating electrostatic MEMS and its driver CMOS-LSI for mobile electronics applications.
Patellar Bone-Grafting for Severe Patellar Bone Loss During Revision Total Knee Arthroplasty (2020)

Careful preoperative physical examination should document range of motion, areas of pain, and patellofemoral tracking and/or instabilityBe prepared to revise the femoral and/or tibial components if malrotated in order to optimize patellofemoral trackingRetain any autogenous bone harvested during component revision to use as patellar bone graftEnsure that allograft bone is available to ensure sufficient restoration of patellar thicknessConsider having allograft tissue available in the event that scar tissue in situ is not adequate to create an envelope for packing the bone graftA bleeding retropatellar surface prepared with a high-speed burr will increase the chance of bone incorporationA watertight closure of the soft-tissue envelope is critical to avoid loss of bone graft during knee range of motion.
NON-MELT PROCESSING OF "LOW-COST", ARMSTRONG TITANIUM AND TITANIUM ALLOY POWDERS (2007)

In the last decade, a considerable effort has been made to develop new methods for producing low cost titanium and titanium powders. The Armstrong process is a new method of producing titanium powder via reducing TiCl4 vapor in molten sodium. The process is scalable, and can be used to produce pre-alloyed powders. Non-melt processing and powder metallurgy approaches are economically viable with the commercially pure powders. In this investigation, several non-melt processing technologies, including vacuum hot pressing, extrusion, roll compaction, and forging techniques, will be evaluated using the Armstrong titanium powders. The metallurgical, chemical, and mechanical properties of the processed titanium samples will be discussed.
Prevention of pertussis across the age spectrum through the use of the combination vaccines PENTACEL™ and ADACEL™ (2006)

Acellular pertussis-containing combination vaccines are widely used in the developed world for the control of pertussis and have been successful in controlling disease in preschool-aged children. Combination vaccines formulated for use in adolescents and adults have been developed more recently and are increasingly being implemented for the control of pertussis in these age groups. One such family of products is PENTACEL (Haemophilus influenzae type b conjugate vaccine reconstituted with component pertussis vaccine and diphtheria and tetanus toxoids adsorbed combined with inactivated poliomyelitis vaccine, DTaP-IPV-Hib), for use in young children, and ADACEL (tetanus and diphtheria toxoids adsorbed combined with component pertussis vaccine, dTap) for use in adolescents and adults. These products have been demonstrated to be safe, immunogenic and effective for the control of pertussis and the other included diseases.
Label-Free Detection of G Protein–SNARE Interactions and Screening for Small Molecule Modulators (2011)

G(i/o)-coupled presynaptic GPCRs are major targets in neuropsychiatric diseases. For example, presynaptic auto- or heteroreceptors include the D(2) dopamine receptor, H(3) histamine receptor, 5HT(1) serotonin receptors, M(4) acetylcholine receptors, GABA(B) receptors, Class II and III metabotropic glutamate receptors, opioid receptors, as well as many other receptors. These GPCRs exert their influence by decreasing exocytosis of synaptic vesicles. One mechanism by which they act is through direct interaction of the Gβγ subunit with members of the SNARE complex downstream of voltage-dependent calcium channels, and specifically with the C-terminus of SNAP25 and the H3 domain of syntaxin1A(1-3). Small molecule inhibitors of the Gβγ-SNARE interaction would allow the study of the relative importance of this mechanism in more detail. We have utilized novel, label-free technology to detect this protein-protein interaction and screen for several small molecule compounds that perturb the interaction, demonstrating the viability of this approach. Interestingly, the screen also produced enhancers of the Gβγ-SNARE interaction.
Ambient Electrosynthesis of Ammonia: Electrode Porosity and Composition Engineering (2018)

Abstract Ammonia, a key precursor for fertilizer production, convenient hydrogen carrier, and emerging clean fuel, plays a pivotal role in sustaining life on Earth. Currently, the main route for NH 3 synthesis is by the heterogeneous catalytic Haber–Bosch process (N 2 +3 H 2 →2 NH 3 ), which proceeds under extreme conditions of temperature and pressure with a very large carbon footprint. Herein we report that a pristine nitrogen‐doped nanoporous graphitic carbon membrane (NCM) can electrochemically convert N 2 into NH 3 in an acidic aqueous solution under ambient conditions. The Faradaic efficiency and rate of production of NH 3 on the NCM electrode reach 5.2 % and 0.08 g m −2 h −1 , respectively. Functionalization of the NCM with Au nanoparticles dramatically enhances these performance metrics to 22 % and 0.36 g m −2 h −1 , respectively. As this system offers the potential to be scaled to industrial levels it is highly likely that it might displace the century‐old Haber–Bosch process.
Middle-of-line plasma dry etch challenges for buried power rail integration (2022)

Buried power rail (BPR), a novel integration approach for further device scaling, brings in new patterning needs and requirements, the most importantly, the challenging middle-of-line (MOL) patterning process steps. In this paper, some of the critical plasma dry etch development processing results for the FinFET device flow with BPR integrated are presented. Mainly, the study was focused on plasma dry etch development of high aspect ratio Via contact to BPR metal (VBPR) and Trench contact etch (M0A) to the source/drain (S/D) device region. We demonstrate the short-free M0A (no attack on the neighboring gates) contact etch to the S/D, with the high etch selectivity values obtained in case of the dielectric SiO2 trench etch to the thin Si3N4 liner (deposited over epitaxial S/D), and subsequently the high selectivity values during SiN liner etch to the underlying S/D (SiN liner etch results in 0nm epitaxial film loss). Patterning of high aspect ratio (HAR) Via consisting of the multi-stack, SiO2/SiN/SiO2/SiN dielectric, landing on the bottom BPR metal was achieved, with the target critical dimension (CD) required to avoid shorting to the adjacent gates. Additionally, we report our learnings on how choice of buried power metal (W, Ru and Mo) impacts the etch requirements, i.e., the etch challenges associated by using Ru and Mo as a replacement for standardly used W metal.
A Retrospective Evaluation of Chemotherapy Regimens in Unselected Patients with Metastatic Non-Small Cell Lung Cancer (2018)

Background: Randomized clinical trials have demonstrated the benefits of chemotherapy in carefully selected non-small cell lung cancer (NSCLC) patients. How generalizable these results are to other NSCLC patients is unresolved. Methods: The outcomes of patients treated with standard chemotherapy regimens (paclitaxel / carboplatin; gemcitabine / carboplatin; pemetrexed / carboplatin; paclitaxel / carboplatin / bevacizumab) off study as first line therapy between 2002 and 2012 at our institution were compared to the reported results of trials supporting the FDA approval of these drugs and/or regimens. Results: In our population, 38.1% of the patients had hypertension, 11.9% of the patients were diabetic, 23.7% had chronic obstructive pulmonary disease (COPD), 11.9% had coronary artery disease (CAD) and 2.1% had renal or liver disease. Notably, the presence of a single or multiple comorbidities was associated with low overall survival compared to matched patients with no comorbidities (p = 0.007). Conclusion: The presence of single or multiple comorbidities is associated with inferior overall survival compared to matched groups without such pre-existing conditions.
Absence of Significant Cellular Dilution During ADH-Stimulated Water Reabsorption (1987)

Water reabsorption across many "tight" urinary epithelia is driven by large transepithelial osmotic gradients and is controlled by antidiuretic hormone (ADH). Numerous investigators have concluded that ADH-induced water reabsorption causes large apparent increases in cell volume with concomitant cytoplasmic dilution. A central question in renal physiology has been how cellular homeostasis is maintained in tight urinary epithelia during antidiuresis. Previous direct measurements of cell membrane permeability to water and the present direct measurements of cell volume in collecting tubules of rabbit kidney cortex by quantitative light microscopy show that cell volume does not change significantly during transcellular water flow. Fluid transported across the epithelium accumulated in lateral and basal intercellular spaces; the effect was an increase in cell height and tubule wall thickness accompanied by maintenance of nearly constant cell volume. The stability of cell volume is a consequence of the relatively high water permeability of the blood-facing cell membrane.
A NEW APPROACH FOR ASSESSMENT OF NARCOTIC PHYSICAL DEPENDENCE USING URINARY SEX-DEPENDENT LOW MOLECULAR WEIGHT PROTEINS IN MALE RATS (1983)

Attempts have been made to examine the relationship between urinary excretion of sex-dependent low molecular weight proteins found only in male rats (LMWP) and morphine physical dependence. Chronic administration of morphine produced a dose-related decrease in urinary LMWP excretion, which was correlated to the intensity of withdrawal signs including body weight loss and abnormal behaviors recognized after naloxone challenge. Furthermore, a statistically high correlation was obtained between the decrease in urinary LMWP excretion and the loss of body weight precipitated by naloxone challenge. LMWP was identified immunologically in the livers, kidneys, and sera using an antibody against purified LMWP. The serum level of LMWP was increased rapidly following bilateral nephrectomy. After chronic treatment with morphine, the LMWP content in the livers, kidneys, and sera were decreased. These findings indicate that the decrease in urinary LMWP excretion induced by chronic administration of morphine can be a useful parameter to assess the development of physical dependence on narcotics on the peripheral level without requiring drug withdrawal and naloxone challenge. This decrease in urinary LMWP may be caused by the inhibition of LMWP synthesis in the liver.
Matrix metalloproteinases in human wounds and epithelial cancer in the skin and oral mucosa (2004)

Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteolytic enzymes that are collectively able to degrade all components of the extracellular matrix (ECM).MMPs influence cell dissociation, death and division, angiogenesis, and the bioavailability of growth factors and cytokines, events needed in wound healing and tumor invasion.Normal cutaneous reepithelialization involves many MMPs, including MMP-1, -9, and -10 in migratory keratinocytes and MMP-3, -19 and -28 in the proliferating zone.However, many of these same MMPs as well as various others, such as MMPs-1, -2, -7, -9, -13, -14 and -26, have been implicated for various cancers.
Status of GOL-NB project (2016)

Overview of the activity on the development of the new multiple-mirror trap GOL-NB to be built in Budker Institute will be presented. This device to be build in BINP in several years as a deep conversion of the existing GOL-3 facility. The device will consist of a central trap with two 0.75 MW neutral beams, two multiple-mirror solenoids, two expander tanks and a plasma gun that creates start plasma. Plasma will be NBI-heated and confined in the central trap that is essentially a compact version of the GDT device with the well-known physics. The multiple-mirror sections should decrease the power and particle losses along the magnetic field. The main physical task of GOL-NB is the direct performance demonstration of the multiple-mirror sections that will change the escaping plasma flow and equilibrium plasma parameters in the central trap depending on the magnetic configuration chosen. In this paper, we will discuss new results in scenario modeling and progress in the hardware, including neutral beam injection system and start plasma source. First experiments on transport of a (1 – 4)×1020 m−3 cold plasma stream through the 3-meter-long solenoids with 0.5 – 4.5 T field are already completed thus demonstrating the performance of start plasma creation system.
Attenuation of gastric mucosal inflammation induced by aspirin through activation of A2Aadenosine receptor in rats (2006)

The specific adenosine A(2A) receptor agonist, ATL-146e, has potent anti-ulcer effects presumably mediated by its anti-inflammatory properties.
A test reaction to assess the presence of Brönsted and the softness/hardness of Lewis acid sites in palladium supported catalysts (2004)

Cyclic ethylene acetal of α-bromopropiophenone gives rise to three distinctive products, each one being specific to Brönsted, hard Lewis and soft Lewis sites, respectively. In the presence of Brönsted sites, hydrolysis of cyclic acetal forms the corresponding α-bromophenone. Hard or soft Lewis sites promote selectively a rearrangement of the phenyl or ethylenedioxy group to form 2-phenylpropionate ester or dioxine, respectively. This test reaction has been used to assess the influence of the support on the catalytic activity of palladium in zeolites. Three series of supports including alkali-exchanged faujasite, Beta zeolites and sepiolites have been tested. It has been observed that the nature of the zeolite plays an important role on the palladium selectivity, basic supports increasing the softness of the palladium Lewis sites. The catalytic test correlates well with electrochemical data about the reduction potential of supported palladium, XPS characterization of the oxidation state of palladium supported on the surface and activity in the Suzuki reaction.
FPGA implementation of a CTC decoder for H-ARQ compliant WiMAX systems (2007)

This paper presents the headlines of a turbo decoder implementation on an FPGA. Optimization techniques and performances are detailed for the implementation of an 802.16e-2005 compliant turbo code. The decoder supported data rates are 1/2, 2/3 and 3/4, the data block sizes are from 6 up to 600 bytes and the maximum number of iterations is 8. The maximum desired throughput value is 16 Mbps.
ChemInform Abstract: Total Synthesis of (.+‐.)‐Deethyleburnamonine and Vindeburnol (RU 24722) with the Corresponding Nitriles as Starting Material. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Adherence of Streptococcus suis capsular type 2 to porcine lung sections. (1991)

The present study was undertaken to evaluate the ability of 33 Streptococcus suis capsular type 2 isolates to adhere to frozen sections of porcine lung. Twenty isolates originated from diseased pigs and 13 from the nasal cavities of clinically healthy pigs. All isolates from diseased animals adhered to lung sections; isolates from pneumonia adhered, in general, in greater numbers than isolates from meningitis. Only four isolates from clinically healthy animals showed a weak adherence to lung sections. Hydrophobic surface properties were also evaluated. All isolates tested appeared to possess a hydrophilic cell surface. The thickness of the capsular material correlated well with the degree of adherence. However, when the adherence capacity of a noncapsulated mutant was compared with that of the parent strain, it was found that the mutant strain had at least the same adherence capacity as the capsulated parent strain. The data suggest that S. suis capsular type 2 isolates involved in pathological conditions can adhere to porcine lung tissue. The adherence activity does not seem to involve hydrophobic interactions. The amount of capsular material seems to influence the adherence activity, but is probably not the only mechanism involved.
26‐2: Extremely High‐Efficient OLED Achieving External Quantum Efficiency over 40% by Carrier Injection Layer with Super‐Low Refractive Index (2018)

Extremely low‐refractive‐index hole‐injection and electron‐injection layers were developed to improve the outcoupling efficiency of an organic light‐emitting diode (OLED). These layers enabled a remarkably high external quantum efficiency of 41% in a bottom‐emission phosphorescent OLED and also improved the current efficiency even in a top‐emission OLED with a microcavity structure.
Testing the Configurations of Redundant Integrated Equipment Complexes (2019)

We consider one of the tasks of managing the redundancy in a heterogeneous integrated complex of technical equipment defined by a system of linear discrete equations. The task consists in testing a predefined configuration of the complex for implementability. We formulate both sufficient and necessary and sufficient conditions for testing configurations formalized by interface matrices. We illustrate the application and efficiency of the proposed testing conditions with an example based on a redundant aircraft motion control system.
Routine single particle CryoEM sample and grid characterization by tomography (2018)

Single particle cryo-electron microscopy (cryoEM) is often performed under the assumption that particles are not adsorbed to the air-water interfaces and in thin, vitreous ice. In this study, we performed fiducial-less tomography on over 50 different cryoEM grid/sample preparations to determine the particle distribution within the ice and the overall geometry of the ice in grid holes. Surprisingly, by studying particles in holes in 3D from over 1000 tomograms, we have determined that the vast majority of particles (approximately 90%) are adsorbed to an air-water interface. The implications of this observation are wide-ranging, with potential ramifications regarding protein denaturation, conformational change, and preferred orientation. We also show that fiducial-less cryo-electron tomography on single particle grids may be used to determine ice thickness, optimal single particle collection areas and strategies, particle heterogeneity, and de novo models for template picking and single particle alignment.
Optimization of Rhodium-Based Catalysts for Mixed Alcohol Synthesis (2012 Progress Report) (2012)

Pacific Northwest National Laboratory has been conducting research to investigate the feasibility of producing mixed alcohols from biomass-derived synthesis gas (syngas). In recent years, this research has primarily involved the further development of catalysts containing rhodium and manganese based on the results of earlier catalyst screening tests. Testing continued in FY 2012 to further improve the Ir-promoted RhMn catalysts on both silica and carbon supports for producing mixed oxygenates from synthesis gas. This testing re-examined selected alternative silica and carbon supports to follow up on some uncertainties in the results with previous test results. Additional tests were conducted to further optimize the total and relative concentrations of Rh, Mn, and Ir, and to examine selected promoters and promoter combinations based on earlier results. To establish optimum operating conditions, the effects of the process pressure and the feed gas composition also were evaluated.
Association of interleukin 1B gene polymorphism and gastric cancers in high and low prevalence regions in China (2003)

IL-1B -511T/T genotypes are associated with gastric cancer in China. The effect of IL-1B polymorphism is less obvious in areas of high prevalence for gastric cancer.
Abstract 19271: Resting and Post Exercise Serum Brain Natriuretic Peptide Levels Do Not Help Differentiate Heart Failure With Normal Ejection Fraction From Respiratory Limitation and Deconditioning in Patients Aged Over 60 Years (2016)

Introduction: Although diagnosis of HFnEF based on elevated resting LV diastolic pressure necessarily results in associated elevation in plasma BNP, several groups have shown that resting LVEDP may be a poor indicator of patients with a cardiac cause for exercise limitation, because of the profoundly dynamic nature of diastolic function on exercise, wrongly diagnosing cardiac limitation in some and missing others. We therefore evaluated the use of both resting and exercise BNP in the prediction of the cause of exercise limitation breathlessness in a community population of patients aged over 60. Hypothesis: Exercise BNP would better distinguish patients with normal LVEF who had a cardiac vs non cardiac cause for exercise limitation. Methods: We measured bedside BNP levels before exercise, at peak exercise, and 15 minutes after a maximal cardio-pulmonary exercise test (CPEX), in 70 elderly (over 60 years) breathless subjects (NYHA ≥2b) and in 42 healthy and 28 hypertensive-but otherwise healthy subjects. All had prior echocardiogram showing LVEF >50% and no significant valve disease. Results: The breathless subjects were classified into HFnEF, respiratory limitation and deconditioning, based on CPEX. There was no statistically significant difference in BNP levels between the three groups at rest, peak exercise and 15 minute post exercise. Furthermore, ROC curves analysis showed while BNP levels could distinguish HFnEF and healthy subjects, there was no clear distinction between the HFnEF and hypertensive groups. Conclusion: Resting, peak-exercise or post-exercise BNP levels do not help identify the cause of breathlessness in an elderly population with normal ejection fraction.
Reliability of Power Devices with Copper Wire Bond (2022)

In this study, we evaluate yield and reliability for a smart power device fabricated in 0.35 μm technology. The wire bonds are formed with 50.8 micron (2 mil) diameter Pd-coated Cu wire. For a conventional wire bond process, there is a risk of damage to interconnect layers under the bond pads, resulting in yield loss and reliability failures. In contrast, by using a segmented wire bond process, the yield loss associated with bond pad damage is eliminated and highly reliable wire bond connections are achieved.