gebhart/patrepeval huggingface dataset:
Expectations for Manuscripts in ACS Sustainable Chemistry & Engineering: Scope Summary and Call for Creativity (2020)

status: Published
Design, Synthesis, and Biological Evaluation of Sulfonyl Acrylonitriles as Novel Inhibitors of Cancer Metastasis and Spread (2015)

The spread of intra-abdominal cancers is a vexing clinical problem for which there is no widely effective treatment. We discovered previously that (2E)-3-[(4-tert-butylphenyl)sulfonyl]acrylonitrile (1) induced cancer cell apoptosis during adhesion to normal mesothelial cells which line the peritoneum. We recently demonstrated that the sulfonylacrylonitrile portion of 1 and hydrophobic aryl substitution were essential for pro-apoptotic activity in cancer cells. Here we synthesized a diverse series of analogues of 1 in order to improve the efficacy and pharmaceutical properties. Analogues and 1 were compared in their ability to cause cancer cell death during adhesion to normal mesothelial cell monolayers. Potent analogues identified in the in vitro assay were validated and found to exhibit improved inhibition of intra-abdominal cancer in two clinically relevant murine models of ovarian and pancreatic cancer spread and metastasis, highlighting their potential clinical use as an adjunct to surgical resection of cancers.
A novel DRAM architecture as a low leakage alternative for SRAM caches in a 3D interconnect context (2009)

This paper presents a DRAM architecture that improves the DRAM performance/power trade-off to increase their usability on low power chip design using 3D interconnect technology. The use of a finer matrix subdivision and buffering the bitline signal at the localblock level allows to reduce both the energy per access and the access time. The obtained performances match those of a typical low power SRAM, while achieving a significant area and static power reduction compared to these memories. The 128 kb memory architecture proposed here achieves an access time of 1.3 ns for a dynamic energy of less than 0.2 pJ per bit. A localized refresh mechanism allows gaining a factor of 10 in static power consumption associated with the cell, and a factor of 2 in area, when compared with an equivalent SRAM.
Does COVID-19 Infection Increase the Risk of Diabetes? Current Evidence (2023)

Incident diabetes risk increased by approximately 60% compared to patients without SARS-CoV-2 infection. Risk also increased compared to non-COVID-19 respiratory infections, suggesting SARS-CoV-2-mediated mechanisms rather than general morbidity after respiratory illness. Evidence is mixed regarding the association between SARS-CoV-2 infection and T1D. SARS-CoV-2 infection is associated with an elevated risk of T2D, but it is unclear whether the incident diabetes is persistent over time or differs in severity over time. SARS-CoV-2 infection is associated with an increased risk of incident diabetes. Future studies should evaluate vaccination, viral variant, and patient- and treatment-related factors that influence risk.
A New Molecular Mechanism To Engineer Protean Agonism at a G Protein–Coupled Receptor (2020)

Protean agonists are of great pharmacological interest as their behavior may change in magnitude and direction depending on the constitutive activity of a receptor. Yet, this intriguing phenomenon has been poorly described and understood, due to the lack of stable experimental systems and design strategies. In this study, we overcome both limitations: First, we demonstrate that modulation of the ionic strength in a defined experimental set-up allows for analysis of G protein-coupled receptor activation in the absence and presence of a specific amount of spontaneous receptor activity using the muscarinic M2 acetylcholine receptor as a model. Second, we employ this assay system to show that a dualsteric design principle, that is, molecular probes, carrying two pharmacophores to simultaneously adopt orthosteric and allosteric topography within a G protein-coupled receptor, may represent a novel approach to achieve protean agonism. We pinpoint three molecular requirements within dualsteric compounds that elicit protean agonism at the muscarinic M2 acetylcholine receptor. Using radioligand-binding and functional assays, we posit that dynamic ligand binding may be the mechanism underlying protean agonism of dualsteric ligands. Our findings provide both new mechanistic insights into the still enigmatic phenomenon of protean agonism and a rationale for the design of such compounds for a G protein-coupled receptor.
LDV Measurement of Confined Parallel Jet Mixing (2000)

Laser Doppler Velocimetry (LDV) measurements were taken in a confinement, bounded by two parallel walls, into which issues a row of parallel jets. Two-component measurements were taken of two mean velocity components and three Reynolds stress components. As observed in isolated three-dimensional wall bounded jets, the transverse diffusion of the jets is quite large. The data indicate that this rapid mixing process is due to strong secondary flows, transport of large inlet intensities, and Reynolds stress anisotropy effects.
Nasal immunization of mice withLactobacillus caseiexpressing the pneumococcal surface protein C primes the immune system and decreases pneumococcal nasopharyngeal colonization in mice (2011)

Streptococcus pneumoniae colonizes the upper respiratory tract of healthy individuals, from where it can be transmitted to the community. Occasionally, bacteria invade sterile niches, causing diseases. The pneumococcal surface protein C (PspC) is a virulence factor that is important during colonization and the systemic phases of the diseases. Here, we have evaluated the effect of nasal or sublingual immunization of mice with Lactobacillus casei expressing PspC, as well as prime-boosting protocols using recombinant PspC, on nasopharyngeal pneumococcal colonization. None of the protocols tested was able to elicit significant levels of anti-PspC antibodies before challenge. However, a significant decrease in pneumococcal recovery from the nasopharynx was observed in animals immunized through the nasal route with L. casei-PspC. Immune responses evaluated after colonization challenge in this group of mice were characterized by an increase in mucosal anti-PspC immunoglobulin A (IgA) 5 days later, a time point in which the pneumococcal loads were already low. A negative correlation between the concentrations of anti-PspC IgA and pneumococcal recovery from the nasopharynx was observed, with animals with the lowest colonization levels having higher IgA concentrations. These results show that nasal immunization with L. casei-PspC primes the immune system of mice, prompting faster immune responses that result in a decrease in pneumococcal colonization.
ChemInform Abstract: Synthesis and Binding Studies of a 1‐Alkyl‐3,6‐diamino‐4‐quinolone Based Receptor for N‐Acylated Dipeptides. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Database Approach to SDN Control Plane Design (2017)

Software-defined networking (SDN) is a well-known example of a research idea that has been reduced to practice in numerous settings. Network virtualization has been successfully developed commercially using SDN techniques. This paper describes our experience in developing production-ready, multi-vendor implementations of a complex network virtualization system. Having struggled with a traditional network protocol approach (based on OpenFlow) to achieving interoperability among vendors, we adopted a new approach. We focused first on defining the control information content and then used a generic database protocol to synchronize state between the elements. Within less than nine months of starting the design, we had achieved basic interoperability between our network virtualization controller and the hardware switches of six vendors. This was a qualitative improvement on our decidedly mixed experience using OpenFlow. We found a number of benefits to the database approach, such as speed of implementation, greater hardware diversity, the ability to abstract away implementation details of the hardware, clarified state consistency model, and extensibility of the overall system.
Supplementary Figure 4 from Targeting BCL2 Overcomes Resistance and Augments Response to Aurora Kinase B Inhibition by AZD2811 in Small Cell Lung Cancer (2023)

&lt;p&gt;Supplementary Figure 4 shows the combination of AZD2811NP with venetoclax is well tolerated in mice and less efficacious in SCLC models with low BCL2 expression.&lt;/p&gt;
Optimization of polymer‐solvent interaction in a multisolvent system by the UNIFAC group‐contribution method (1986)

Abstract The solubility parameter scheme is an exceptionally useful tool for predicting the solubility behavior of simple polymer systems. However, this scheme is unable to handle well enough complicated systems, such as those involving donor‐acceptor interactions and those containing more than two solvents. More advanced thermodynamic treatments and computer techniques, such as UNIFAC, can be a key to solving these kinds of problems. The UNIFAC group‐contribution method utilizes a volume parameter and a surface‐area parameter for each structural group and a pair of interaction‐energy parameters for each pair of groups, which can be deduced from experimental activity data. The method was originally derived for mixtures of ordinary liquids and has been extended to polymer solutions by adding a free‐volume correction. The modified UNIFAC method can be used to estimate the activities of solvents in a polymer solution, even when no experimental data are available for the mixture. In the present study, the UNIFAC method was applied to optimize polymer‐solvent interactions in three‐solvent systems. A three‐dimensional plot, displaying polymer activity as a function of the solvent composition, was constructed for each polymer system. The minimum in polymer activity was used as the criterion for maximum polymer‐solvent interaction. Dissolution rate and solution clarity were used to test the polymer‐solvent interaction experimentally. Comparison of theoretical predictions with experimental results indicated that a better agreement could be obtained by using the UNIFAC method rather than the solubility parameter method.
Supporting polyrepresentation in a quantum-inspired geometrical retrieval framework (2010)

The relevance of a document has many facets, going beyond the usual topical one, which have to be considered to satisfy a user's information need. Multiple representations of documents, like user-given reviews or the actual document content, can give evidence towards certain facets of relevance. In this respect polyrepresentation of documents, where such evidence is combined, is a crucial concept to estimate the relevance of a document. In this paper, we discuss how a geometrical retrieval framework inspired by quantum mechanics can be extended to support polyrepresentation. We show by example how different representations of a document can be modelled in a Hilbert space, similar to physical systems known from quantum mechanics. We further illustrate how these representations are combined by means of the tensor product to support polyrepresentation, and discuss the case that representations of documents are not independent from a user point of view. Besides giving a principled framework for polyrepresentation, the potential of this approach is to capture and formalise the complex interdependent relationships that the different representations can have between each other.
Chest Pain without Significant Coronary Stenosis after Implantation of Sirolimus-Eluting Stents (2009)

We encountered a case of exercise-induced chest pain after the implantation of sirolimus-eluting stents (SESs). She had no history of previous chest pain, and an exercise stress test just after the implantation of the SESs was negative without any symptoms. However, six months after the implantation of the SESs, she began to experience frequent episodes of severe chest pain on effort in spite of there being no significant coronary stenosis. Interestingly, severe coronary vasoconstriction was induced by an intracoronary administration of acetylcholine, and exercise stress testing revealed positive findings with chest pain and ST-T segment depression on ECG. An intensive treatment with two types of calcium channel blockers could readily and completely abolish the exercise-induced chest pain and ST-T segment depression on the ECG. In view of these findings, we presumed that coronary microvessel dysfunction and/or exercise-induced coronary vasoconstriction leading to myocardial ischemia had appeared 6 months after the implantation of the SESs. Although the pathogenesis of this phenomenon could not be completely elucidated, the anatomical and functional abnormalities of the coronary arteries associated with the implantation of the SESs may have been one of the most important mechanisms.
Design of transmission and multiplexing systems for broadband packet networks (1988)

Dynamic time-division multiplexing (DTDM) is a flexible network transport technique capable of handling both continuous and bursty traffic effectively. By using three different multiplexing architectures in the network, DTDM permits graceful evolution of the existing circuit switching network into a flexible broadband packet communications network supporting integrated voice, data, and video traffic. The first multiplexing stage uses a packet assembler to multiplex different broadband services into a common DTDM-format serial bit stream. The second multiplexing stage uses a statistical packet multiplexer to concentrate network traffic for more efficient use of transmission facilities. The third multiplexing stage uses a synchronous time-division multiplexer for high-speed point-to-point transparent transmission. The multiplexer uses a simple tributary synchronization scheme based on positive and negative block justification, which combines the concept of controlled-slip and bit-stuffing techniques while maintaining information integrity. A generic CMOS LSI chip has been designed for use in the three-stage multiplexing system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Susceptibility loci for murine HIV-associated nephropathy encode trans-regulators of podocyte gene expression (2009)

Multiple studies have linked podocyte gene variants to diverse sporadic nephropathies, including HIV-1-associated nephropathy (HIVAN). We previously used linkage analysis to identify a major HIVAN susceptibility locus in mouse, HIVAN1. We performed expression quantitative trait locus (eQTL) analysis of podocyte genes in HIV-1 transgenic mice to gain further insight into genetic susceptibility to HIVAN. In 2 independent crosses, we found that transcript levels of the podocyte gene nephrosis 2 homolog (Nphs2), were heritable and controlled by an ancestral cis-eQTL that conferred a 3-fold variation in expression and produced reactive changes in other podocyte genes. In addition, Nphs2 expression was controlled by 2 trans-eQTLs that localized to the nephropathy susceptibility intervals HIVAN1 and HIVAN2. Transregulation of podocyte genes was observed in the absence of HIV-1 or glomerulosclerosis, indicating that nephropathy susceptibility alleles induce latent perturbations in the podocyte expression network. Presence of the HIV-1 transgene interfered with transregulation, demonstrating effects of gene-environment interactions on disease. These data demonstrate that transcript levels of Nphs2 and related podocyte-expressed genes are networked and suggest that the genetic lesions introduced by HIVAN susceptibility alleles perturb this regulatory pathway and transcriptional responses to HIV-1, increasing susceptibility to nephropathy.
Monitoring of Optical Networks Using Correlation-Aided Time-Domain Reflectometry with Direct and Coherent Detection (2023)

We report on methods to monitor the transmission path in optical networks using a correlation-based OTDR technique with direct and coherent detection. A high probing symbol rate can provide picosecond-accuracy of the fiber propagation delay, while a sensitive phase detection with a high repetition rate allows the monitoring of dynamic effects in the vicinity of the fiber. We discuss various approaches to evaluate the measured traces and show the results of a few monitoring applications.
Cyber Security through Multidimensional Data Decompositions (2016)

Traditional machine learning approaches are plagued with problems for practical use in operational cyber security. The class of unsupervised learning algorithms called tensor decompositions provide a new approach for analyzing network traffic data that avoids these traditional problems. Tensors are a natural representation for multidimensional data as an array with arbitrary dimensions. Tensor decompositions factor the data into components, each of which represents a different pattern of activity from within the original data.We use ENSIGN, a tensor decomposition toolbox developed by Reservoir Labs, in the security operations center for the SCinet network at SC15 - The International Conference for High Performance Computing, Networking, Storage and Analysis. ENSIGN integrates naturally into an operational cyber security framework by extracting anomalous patterns of network traffic. In this paper, we present two case studies highlighting specific actionable results: one, discovering an external attacker and tracing the evolution of the attack over time, and the other, extracting an example of data exfiltration that the actor disguised as DNS activity and cleanly separating it from normal DNS activity. Through proof-of-concept experiments at SC15, we successfully demonstrate concrete and practical use of ENSIGN and make a critical step forward towards delivering an integrated tensor analysis engine for network security.
Perfect reconstruction nonuniform filter banks with linear phase (2000)

A nonuniform filter bank divides the band nonuniformly according to the properties of the signal, which is expected to be more effective than a uniform division filter bank in applications such as subband coding. The structure of the nonuniform filter bank, however, is complex. In particular, no investigation has been made of the linear-phase nonuniform filter bank. From such a viewpoint, this paper considers a perfect reconstruction nonuniform filter bank with linear phase, and derives the necessary and sufficient conditions for a perfect reconstruction system as well as for a linear-phase filter. Then, a design method is presented based on the amplitude distortion in the frequency domain and the elimination of aliasing. By the proposed method, the nonuniform filter bank can be designed directly without using the equivalent transformation to the uniform filter bank. © 2000 Scripta Technica, Electron Comm Jpn Pt 3, 83(8): 103–114, 2000
Factors Associated with Potential Medication-Herb/Natural Product Interactions in a Rural Community (2020)

Use of both conventional medicines and herbs/natural products are increasing in the United States (US). Consequently, individuals are more likely to be exposed to potentially harmful interactions between these products.
Assessment of current cybersecurity practices in the public domain : cyber indications and warnings domain. (2010)

This report assesses current public domain cyber security practices with respect to cyber indications and warnings. It describes cybersecurity industry and government activities, including cybersecurity tools, methods, practices, and international and government-wide initiatives known to be impacting current practice. Of particular note are the U.S. Government's Trusted Internet Connection (TIC) and 'Einstein' programs, which are serving to consolidate the Government's internet access points and to provide some capability to monitor and mitigate cyber attacks. Next, this report catalogs activities undertaken by various industry and government entities. In addition, it assesses the benchmarks of HPC capability and other HPC attributes that may lend themselves to assist in the solution of this problem. This report draws few conclusions, as it is intended to assess current practice in preparation for future work, however, no explicit references to HPC usage for the purpose of analyzing cyber infrastructure in near-real-time were found in the current practice. This report and a related SAND2010-4766 National Cyber Defense High Performance Computing and Analysis: Concepts, Planning and Roadmap report are intended to provoke discussion throughout a broad audience about developing a cohesive HPC centric solution to wide-area cybersecurity problems.
Saturation spectroscopy of NV− centers in diamond (2018)

We report saturation of NV− centers resulting in ~40% inversion level under 632nm pumping. Δk/ko kinetics revealed long recovery time of NV− centers after photoionization under 532nm pump, which involved different relaxation channels depending on the probe beam wavelengths.
Intestinal spirochaetes colonizing aborigines from communities in the remote north of Western Australia. (1992)

Intestinal spirochaetal bacteria were isolated from 59 of 181 (32.6%) faecal samples obtained from Aboriginal children and a few adults living in communities in the Kimberley region in the north of Western Australia. Colonization was more common in young Aborigines between 2 and 18 years of age than it was in adults, or in babies and children less than 2 years of age. Three of 22 Aboriginal children who were sampled on two consecutive years were colonized on both occasions. None of four other children were found to be consistently colonized with the bacteria when sampled on three sequential years, but three were positive on two consecutive visits and the other child was positive on the first and third sampling. Most Aboriginal children had abnormal or watery stools, and both abnormal and watery stool samples were significantly more likely to contain spirochaetes than were normal samples. However, it was not possible to prove that the spirochaetes were the cause of the diarrhoea. In contrast, spirochaetes were only recovered from 8 of 695 (1.2%) faecal samples that were obtained from other mainly non-Aboriginal children and adults in Western Australia or the Northern Territory of Australia, even though most of these individuals were suffering from gastrointestinal disturbances.
11C-DPA-713: A Novel Peripheral Benzodiazepine Receptor PET Ligand for In Vivo Imaging of Neuroinflammation (2007)

(11)C-DPA-713 displays a higher signal-to-noise ratio than (11)C-PK11195 because of a lower level of unspecific binding that is likely related to the lower lipophilicity of (11)C-DPA-713. Although further studies in humans are required, (11)C-DPA-713 represents a suitable alternative to (11)C-PK11195 for PET of PBR as a tracer of neuroinflammatory processes induced by neuronal stress.