gebhart/patrepeval huggingface dataset:
Ileal DALM in Crohnʼs Disease: An Overlooked Entity? (2015)

Background: Patients with inflammatory bowel disease (IBD) are at an increased risk for developing neoplasia. Dysplasia associated lesions or masses (DALMs) are traditionally described in the colon and may represent underlying malignancy. Current surveillance protocols for malignancy generally require colonic biopsies. Small bowel malignancy among patients with Crohn's Disease (CD) has been described, but surveillance protocols for these patients have not been well defined. Case Report: We report here a 62 year old male with a history of umbilical hernia repair who presented with abdominal pain, nausea, and vomiting. He was previously diagnosed with mixed-pattern irritable bowel syndrome and had two episodes of small bowel obstructions (SBO) that were attributed to adhesions and managed conservatively. He had a heavy smoking and NSAID use history. The patient had never had a colonoscopy before and denied a family history of IBD or GI malignancy. Physical exam was significant for a distended abdomen. CRP was elevated at 3.82 mg/dL (normal < 0.5 mg/dL) and ESR was normal. A CT scan showed partial SBO with a long segment of ileal wall thickening. Colonoscopy showed fistulae at 45 and 55 cm from the anal verge. Abnormal polypoid lesions were seen in the terminal ileum (Fig 1) and biopsies showed tubulovillous-like lesion with low grade dysplasia, located within the distal portion of inflamed ileum compatible with DALM (Fig 3). A definitive diagnosis of CD could not be made and hence no medical therapy was started. CT enterography showed inflammation involving 20 cm of the distal ileum. A retrograde double balloon enteroscopy was performed, but the ileum could not be reached.Figure 1Figure 3As malignancy could not be ruled out, the decision was made for exploratory laparotomy that showed creeping fat and severe distal ileitis with enter-entero and entero-sigmoid fistulas. The patient underwent ileosigmoid fisula closure, and ileocolic resection with primary ileo-ascending colon anastomosis. Gross pathology confirmed severe Crohn's ileitis with tubulovillous-like lesions in TI with low grade dysplasia compatible with DALM in the distal ileum (Fig 2,3). No colitis was appreciated.Figure 2Conclusion: This case report demonstrates a DALM that affected the distal ileum in the setting of severe untreated ileal Crohn's. This brings into question the role for endoscopic surveillance and possible need for obtaining tissue to evaluate for malignancy among patients with CD with small bowel involvement.
Late Breaking Abstract - Transvenous stimulation thresholds of the left and right phrenic nerves using a single catheter via jugular access (2019)

<b>Introduction:</b> An investigational electrophrenic transvenous neurostimulation respiration (ETNR) catheter (LIVE Catheter<sup>®</sup>, Lungpacer<sup>®</sup>) and phrenic nerve stimulator device were studied for the safety and feasibility of catheter insertion/removal, and left/right ETNR. The catheter insertion point was the left jugular vein, instead of the left subclavian vein. <b>Methods:</b> 13 subjects were consented, enrolled, anesthetized and mechanically ventilated. The catheter was placed prior to the scheduled elective surgical procedure, inserted in the left internal (n=9) or external (n=4) jugular vein. Placement was confirmed by fluoroscopy. After confirming phrenic nerve capture, stimulation was delivered in the ventilator’s inspiratory phase, causing diaphragm contractions. After evaluation, the catheter was removed. Safety was assessed based on adverse events. <b>Results:</b> Phrenic nerve capture was observed in all 13 patients (n=11, left and right; n=2, right-only). Stimulation thresholds were equivalent left and right (1551±959nC, n=11; 1711±1174nC, n=13; p=0.37). The insertion point was easily accessed. Stimulation of captured phrenic nerves resulted in diaphragm contraction. The catheter was easily removed. No device- or procedure-related adverse events were noted during the study, post-procedure, or at two-week follow-up. <b>Conclusions:</b> Safety and feasibility of ETNR via jugular access were confirmed. Effective ETNR was observed in all patients evaluated. Stimulation thresholds were equivalent for the left and right phrenic nerves, indicating that there was no negative impact on left phrenic nerve capture due to the tortuosity of the catheter pathway when inserted in the left jugular vein.
Supplementary Methods, Table S1, and Figures S1-S6 from Selective and Concentrated Accretion of SN-38 with a CEACAM5-Targeting Antibody–Drug Conjugate (ADC), Labetuzumab Govitecan (IMMU-130) (2023)

&lt;p&gt;Supplementary Table S1. Extraction efficiency for isolation of SN-38 in buffer with or without human serum albumin (HSA) or from the ADC with or without acid hydrolysis followed by extraction; Supplementary Figure S1. Schematic depiction of the conjugation of CL2A-SN-38 to mildly reduced IgG yielding site-specifically coupled SN-38 to 8 well-defined sites; Supplementary Figure S2. CL2A-SN38 amide capped with N-acetylcysteine; Supplementary Figure S3. SDS-Page gels comparing profiles for labetuzumab (unconjugated hMN-14 IgG) and labetuzumab govitecan (CL2A-SN-38 conjugated hMN-14 IgG; IMMU-130); Supplementary Figure S4. In vitro cell binding assay performed on LS174T cells, evaluating the binding of unconjugated hMN-14 IgG and SN-38-conjugated hMN-14 IgG (IMMU-130); Supplementary Figure S5. Stability of IMMU-130 in serum from different sources; Supplementary Figure S6. Evaluation of lactone ring stability of the CL2A-linked SN-38 compared to SN-38 at pH 7.4.&lt;/p&gt;
p53 Mutation and Locoregional Treatment Failure in Head and Neck Squamous Cell Carcinoma (1996)

Mutation of the p53 gene is associated with an increased risk of locoregional failure in patients with invasive head and neck squamous cell carcinoma who are treated with radiation therapy.
Association between cross-reacting Escherichia coli K100 and disease caused by Haemophilus influenzae type b (1978)

An unexpected association between Haemophilus influenzae type b (HIB) disease and simultaneous intestinal colonization with cross-reacting Escherichia coli K100 strains is reported. E. coli K100 were found in 18 of 92 (19.5%) HIB patients, compared with 2.5% in healthy individuals of comparable age and in none of 21 patients with meningitis caused by other bacteria. There was no difference in disease outcome, serum antibodies, and circulating HIB antigen between the E. coli K100-positive and -negative HIB patients. Possible explanations and implications of this association are discussed.
Simulation of a Telecom-Provider Driven Reference QKD-Network (2019)

In the last 15 years different types of QKD-networks have been demonstrated in the field. These show significant advantages compared to QKD-links and utilize i.a. the following functionalities: switching [1]; trusted nodes to increase distances and resiliency by enabling dynamic routing [2]; lab-demos of star-shaped PON-structures to distribute the keys to many users [3] and star-shaped switched networks incorporating entanglement [4]. Only recently the largest QKD-network has been put into operation in China [5]. So far, all these successful technology demonstrators failed, however, to trigger real-world QKD deployment scenarios by telecom operators.
Pneumococcal colonization in older adults (2016)

Although this study included a relatively small number of subjects and has been performed in a limited geographic setting, results showed that pneumococcal colonization in older people is common, and the monitoring of carriers can offer useful information about the circulation of this pathogen among older people and the potential protective effect of pneumococcal vaccines. Because the colonization in most cases involves the strains that are included in PCV13, this vaccine could be useful in the prevention of pneumococcal infections in the overall population of older people. In subjects with respiratory allergies and in those with co-morbidities, the addition of the PPV23 to PCV13 should be recommended. Due to the low vaccination coverage, urgent educational programmes are required to inform older adults and their medical doctors of the risks of pneumococcal infection and the efficacy and safety of the available pneumococcal vaccines.
Effect of Eutectic Mixture of Local Anesthetics on Pain Response and Analgesic Requirement During Lithotripsy Procedures (1995)

Comment: I am not surprised that there was not opioid-sparing effect in these patients. Anxiety related to the procedure itself as well as ureter spasm cannot be managed with topical local anesthetic alone and requires systemic medication to manage the patient's physical and psychic discomfort. I agree with the authors' conclusion that EMLA cream cannot be recommended for use with this procedure. EMLA cream provides no benefit with respect to analgesic efficacy or time to discharge, and it is expensive and inconvenient to use.
Chirurgie de l’œil par laser femtoseconde (2017)

Depuis le LASIK (laser in situ keratomileusis), première opération de chirurgie de l’œil réalisée à l’aide d’un laser femtoseconde, les applications rendues possibles grâce à ce type de laser n’ont cessé de se développer. La sophistication des systèmes utilisés lors de ces opérations nécessite une collaboration étroite entre les praticiens et les constructeurs, notamment pour répondre aux inconforts et aux effets secondaires ressentis par certains patients.
Expanding quasiperiodicity in soft matter: Supramolecular decagonal quasicrystals by binary giant molecule blends (2022)

The quasiperiodic structures in metal alloys have been known to depend on the existence of icosahedral order in the melt. Among different phases observed in intermetallics, decagonal quasicrystal (DQC) structures have been identified in many glass-forming alloys yet remain inaccessible in bulk-state condensed soft matters. Via annealing the mixture of two giant molecules, the binary system assemblies into an axial DQC superlattice, which is identified comprehensively with meso-atomic accuracy. Analysis indicates that the DQC superlattice is composed of mesoatoms with an unusually broad volume distribution. The interplays of submesoatomic (molecular) and mesoatomic (supramolecular) local packings are found to play a crucial role in not only the formation of the metastable DQC superlattice but also its transition to dodecagonal quasicrystal and Frank-Kasper σ superlattices.
Reduction of Periodic Motion Artifacts in Photoplethysmography (2016)

Accelerometry provided a more reliable motion reference signal. The proposed algorithm can be of significance for monitoring in ADL, CPX, or CPR, by providing artifact-reduced PPG signals for improved IBI and SpO <sub>2</sub> measurements during periodic motion.
Regulation by ATP and ADP of CFTR Chloride Channels That Contain Mutant Nucleotide-Binding Domains (1992)

Regulation of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is unusual in that phosphorylated channels require cytosolic adenosine triphosphate (ATP) to open. The CFTR contains two regions predicted to be nucleotide-binding domains (NBDs); site-directed mutations in each NBD have now been shown to alter the relation between ATP concentration and channel activity, which indicates that ATP stimulates the channel by direct interaction with both NBDs. The two NBDs are not, however, functionally equivalent: adenosine diphosphate (ADP) competitively inhibited the channel by interacting with NBD2 but not by interacting with NBD1. Four cystic fibrosis-associated mutations in the NBDs reduced absolute chloride channel activity, and one mutation also decreased the potency with which ATP stimulates channel activity. Dysfunction of ATP-dependent stimulation through the NBDs may be the basis for defective CFTR chloride channel activity in some cystic fibrosis patients.
Microstructure evolution in metal forming processes: Modelling and applications, chapter Techniques for modelling microstructure in metal forming processes (2012)

International audience
A Short Synthesis of the Mould Metabolite (R)-(+)-Carolinic Acid from (S)-Lactic Acid (2016)

(<i>R</i>)-(+)-Carolinic acid was prepared in seven steps and 59% yield from inexpensive benzyl <sc>l</sc>-lactate, the configuration of which was inverted by a Mitsunobu reaction with trifluoroacetate. The resulting benzyl <sc>d</sc>-lactate was cyclised by a domino addition–Wittig alkenation reaction with Ph<sub>3</sub>PCCO. The product tetronic acid was acylated with a second equivalent of this ylide to give a 3-acylylidenetetronic acid, which was olefinated directly with <i>tert</i>-butyl glyoxylate. The product alkene was hydrogenated and deprotected to afford pure crystalline (<i>R</i>)-(+)-carolinic acid, which proved inactive against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i> mutant D21f2.
Oxide breakdown model and its impact on SRAM cell functionality (2003)

The influence of the oxide hard breakdown (HBD) in an SRAM cell on the performance of a circuit that includes the cell, together with the bit select circuit and sense amplifier for the read and write process of the cell, have been analyzed. The analysis of the impact of oxide HBD on this circuit has been performed through the variation of different parameters as the bitline differential voltage and the read and write delays of the cell for different levels of oxide HBD damage in the cell. The results show that oxide BD between gate and source of the NFETs of the SRAM cell seems to have more influence in the circuit performance than in other cell positions.
Discovery ofN-(3-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a Selective Inhibitor of Human Neuronal Nitric Oxide Synthase (nNOS) for the Treatment of Pain (2011)

3,6-Disubstituted indole derivatives were designed, synthesized, and evaluated as inhibitors of human nitric oxide synthase (NOS). Bulky amine containing substitution on the 3-position of the indole ring such as an azabicyclic system showed better selectivity over 5- and 6-membered cyclic amine substitutions. Compound (-)-19 showed the best selectivity for neuronal NOS over endothelial NOS (90-fold) and inducible NOS (309-fold) among the current series. Compounds 16 and (-)-19 were shown to be either inactive or very weak inhibitors of human cytochrome P450 enzymes, indicating a low potential for drug-drug interactions. Compound 16 was shown to reverse thermal hyperalgesia in vivo in the Chung model of neuropathic pain. Compound 16 was also devoid of any significant vasoconstrictive effect in human coronary arteries, associated with the inhibition of human eNOS. These results suggest that 16 may be a useful tool for evaluating the potential role of selective nNOS inhibitors in the treatment of pain such as migraine and CTTH.
Application of Digging Control based on the Center-of-Mass Velocity of the Attachment of a Hydraulic Excavator (2019)

Superior operation skills for hydraulic excavators are learned over time. Therefore, it is difficult to improve the skills of non-expert operators quickly, and their work needs to be supported. This paper presents a control system, which realizes smooth digging (similar to that performed by expert operators), based on the Center of Mass velocity of the attachment as an index. In addition, corresponding to the system switching caused by the digging reaction force, a controller gain tuning method that uses the Fictitious Exogenous Signal is proposed. The proposed method is applied to a hydraulic excavator, and its effect is verified.
Cross-Linked Polymer−Ionic Liquid Composite Materials (2003)

A series of composites, some with permanent porosity, comprising polymers and ionic liquids have been prepared by in-situ polymerization. The characteristics of both composites and isolated polymers have been investigated. Slow mass and phase transfer characterize the interaction with a range of polymers (1−17) in the N,N‘-dialkylimidazolium ionic liquids, [emim]BF4, [bmim]PF6, or [omim]N(SO2CF3)2. Free-radical homopolymerization of 1-vinyl-2-pyrrolidinone in [bmim]PF6 or of 4-vinylpyridine in [omim]N(SO2CF3)2 gave viscous solutions from which polymer (Mw = 162 500 and 71 500 g mol-1, respectively) could be isolated. Detectable ionic liquid residues were retained in the isolated polymers despite five reprecipitations from methanol. Copolymerization of 4-vinylpyridine (VP) with >5% divinylbenzene (DVB) or trimethylolpropane trimethacrylate (TRIM) in [omim]N(SO2CF3)2, and homopolymerizations of the cross-linking monomers on their own, led with 90−100% monomer conversion to a series of gel-like composite materials, B−H, from which cross-linked polymers, B‘−H‘, could be isolated by Soxhlet extraction of the ionic liquid. Copolymers of VP with 5−30% DVB (E‘, F‘) showed a low degree of permanent porosity in the dry state. However, poly(DVB) (G‘) and poly(TRIM) (H‘) have bulk densities (<0.6 g cm-3), intrusion volumes (>0.9 cm3 g-1), BET surface areas (70−320 m2 g-1), and morphology (from SEM studies) which demonstrate the porogenic character of the ionic liquids used. Comparisons with the related products I and J obtained in toluene reveal the sensitivity of these systems both to the properties of the porogen solvent and to the monomer used.
Calphad Modeling and Experimental Validation of Multi‐component Systems for Cast Titanium Alloy Development (2016)

Computational thermodynamics and CALPHAD (CALculation of PHAse Diagram) modeling are important tools used in materials design and process development. However, the thermodynamic databases for multi-component titanium systems are not sufficient and lack experimental validation. It is essential to establish a scientific foundation of computational thermodynamics of titanium alloys to achieve accelerated design and optimization of these multi-component alloys for structural applications. In this paper, the ongoing effort to investigate the phase equilibria of Ti-Al-Mn ternary system by CALPHAD approach and experiment is presented.
Jansenismus und Irenik (2003)

info:eu-repo/semantics/published
Gas Phase Photochemical Synthesis of II/VI Metal Sulfide Films and in Situ Luminescence Spectroscopic Identification of Photofragments (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTGas Phase Photochemical Synthesis of II/VI Metal Sulfide Films and in Situ Luminescence Spectroscopic Identification of PhotofragmentsJinwoo Cheon and Jeffrey I. ZinkView Author Information Department of Chemistry and Biochemistry University of California Los Angeles, California 90095 Cite this: J. Am. Chem. Soc. 1997, 119, 16, 3838–3839Publication Date (Web):April 23, 1997Publication History Received30 December 1996Revised3 March 1997Published online23 April 1997Published inissue 1 April 1997https://pubs.acs.org/doi/10.1021/ja964452ghttps://doi.org/10.1021/ja964452grapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views331Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chemical vapor deposition,Luminescence,Materials,Precursors,Thin films Get e-Alerts
Perceptual approaches to finding features in data (2013)

Electronic imaging applications hinge on the ability to discover features in data. For example, doctors examine diagnostic images for tumors, broken bones and changes in metabolic activity. Financial analysts explore visualizations of market data to find correlations, outliers and interaction effects. Seismologists look for signatures in geological data to tell them where to drill or where an earthquake may begin. These data are very diverse, including images, numbers, graphs, 3-D graphics, and text, and are growing exponentially, largely through the rise in automatic data collection technologies such as sensors and digital imaging. This paper explores important trends in the art and science of finding features in data, such as the tension between bottom-up and top-down processing, the semantics of features, and the integration of human- and algorithm-based approaches. This story is told from the perspective of the IS and T/SPIE Conference on Human Vision and Electronic Imaging (HVEI), which has fostered research at the intersection between human perception and the evolution of new technologies.
Spectral Triangulation Molecular Contrast OCT with Indocyanine Green as the Contrast Agent (2004)

We report the use of indocyanine green (ICG), a FDA approved dye routinely used in angiography procedures, as a contrast agent for molecular contrast optical coherence tomography (MCOCT). We introduce “spectral triangulation” as an enhancement to spectroscopic OCT which acquires 3 consecutive OCT scans at three even spaced wavelength intervals centered at an absorption maximum a molecular dye of interest. We then extract a difference image based on the two scans, which reveals the distribution of the molecule within the target sample. We demonstrate the operation of this MCOCT modality in a target sample containing a mixture of 0.25% (vol. conc.) 0.1 μm latex microspheres and 60 μM of ICG.
Improved Meshless Method for Simulating Incompressible Fluids on GPU (2017)

Meshless methods to simulate fluid flows have been increasingly evolving through the years since they are a great alternative to deal with large deformations, which is where mesh-based methods fail to perform efficiently. A well known meshless method is the Moving Particle Semi-implicit (MPS) method, which was designed to simulate free-surface truly incompressible fluid flows. Many variations and refinements of the method's accuracy and precision have been proposed since its creation and, due to these, it has proved to be very useful in a wide range of naval and mechanical engineering problems. However, one of its drawbacks is high computational load and some quite time-consuming functions, which prevents it to be more used in Computer Graphics and Virtual Reality applications. Graphics Processing Units (GPU) provide unprecedented capabilities for scientific computations. To promote the GPU-acceleration, the solution of the Poisson Pressure equation was brought into focus. This work benefits from some of the techniques presented in the related work and also from the CUDA language in order to get a stable, accurate and GPU-accelerated MPS method, which is this work's main contribution. It is shown that the GPU version of the method developed can perform from, approximately, 6 to 10 times faster with the same reliability as the CPU version, both extended to three dimensions. Lastly, a simulation containing a total of 62,600 particles is fully rendered in 3D.
Supplementary Video 2 from Axon Guidance Factor SLIT2 Inhibits Neural Invasion and Metastasis in Pancreatic Cancer (2023)

&lt;p&gt;AVI file - 2043KB, Recording of unidirectional migration of MiaPaCa cells along a contacted neurite from a DRG-tumor cell co-culture assay (Example 2).&lt;/p&gt;