gebhart/patrepeval huggingface dataset:
The PARIS concept: an experimental demonstration of sea surface altimetry using GPS reflected signals (2001)

This paper presents the passive reflectometry and interferometry system (PARIS) concept and how it originated in the European Space Agency (ESA), Noordwijk, The Netherlands, in 1993 as a novel method to perform mesoscale ocean altimetry. The PARIS concept uses signals of opportunity such as the signals from the global navigation satellite systems (GNSS), which are reflected off the ocean surface to perform mesoscale ocean altimetry. Essentially, the relative delay between the direct and the reflected signals received from a Low Earth Orbit satellite provides information about sea surface height. The paper describes an original experiment on sea surface altimetry using GPS-reflected signals. The objective of the experiment was to demonstrate the potential of the PARIS concept. This experiment is the first one ever published on performing sea surface height estimations using reflected navigation signals in a controlled environment. The key result of the experiment is the demonstration of a root mean squared (RMS) height accuracy within 5 s of 1% of the used code chip (3 m for C/A code). Direct extrapolation of this experimental result to the 10-times higher chip rate P-code signal allows us to predict a height error of 30 cm in 5 s, provided adequate models are used to take into account systematic effects. The paper ends presenting the potential of the PARIS concept for long term ocean altimetric observations in view of the current trends of the GNSS systems.
A Convergent Ring‐Closing Metathesis Approach to Carbohydrate‐Based Macrolides with Potential Antibiotic Activity. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
iFlorida Model Deployment Final Evaluation Report (2009)

This document is the final report for the evaluation of the USDOT-sponsored Surface Transportation Security and Reliability Information System Model Deployment, or iFlorida Model Deployment. This report discusses findings in the following areas:\n\nITS deployment and operations\n\nMaintaining a Network of Field Devices\n\nUsing Toll Tag Readers for Traffic Monitoring\n\nInterfacing TMC and FHP CAD Systems\n\nUsing Dynamic Message Signs for Traveler Information \n\nImplementing Variable Speed Limits\n\nStatewide Operations\n\nEvacuation Operations\n\nTraveler Information Operations\n\nWeather Data\n\nTransportation Security \n This document is the final report for the evaluation of the USDOT-sponsored Surface Transportation Security and Reliability Information System Model Deployment, or iFlorida Model Deployment. This report discusses findings in the following areas: ITS deployment and operations; Maintaining a Network of Field Devices; Using Toll Tag Readers for Traffic Monitoring; Interfacing TMC and FHP CAD Systems; Using Dynamic Message Signs for Traveler Information; Implementing Variable Speed Limits; Statewide Operations; Evacuation Operations; Traveler Information Operations; Weather Data; and Transportation Security. It discusses costs and benefits associated with iFlorida activities in each of these areas and lessons learned in pursuing those activities.\n
Design of a Fault-tolerant Job-flow Manager for Grid Environments Using Standard Technologies, Job-flow Patterns, and a Transparent Proxy. (2008)

The execution of job flow applications is a reality today in academic and industrial domains. Current approaches to execution of job flows often follow proprietary solutions on expressing the job flows and do not leverage recurrent job-flow patterns to address faults in Grid computing environments. In this paper, we provide a design solution to development of job-flow managers that uses standard technologies such as BPEL and JSDL to express job flows and employs a two-layer peer-to-peer architecture with interoperable protocols for crossdomain interactions among job-flow mangers. In addition, we identify a number of recurring job-flow patterns and introduce their corresponding fault-tolerant patterns to address runtime faults and exceptions. Finally, to keep the business logic of job flows separate from their fault-tolerant behavior, we use a transparent proxy that intercepts job-flow execution at runtime to handle potential faults using a growing knowledge base that contains the most recently identified job-flow patterns and their corresponding fault-tolerant patterns.
The Photoelectrochemical Oxidation of (100), (111), and (111) n ‐ InP and n ‐ GaAs (1983)

The photoelectrochemical oxidation of (100), (111), and () and in several acidic solutions has been investigated. Specific interactions between the single crystal semiconductors and solvent selectively reveal crystal faces other than those originally exposed to the solvent. The relative stability of the faces is . The first case of electron injection during the photoanodic dissolution of III–V compound semiconductors has been observed with (100) and () . Nucleophilic attack by Cl− or Br− produce intermediates whose potential and kinetics allow electron injection into the semiconductor conduction band reducing the number of photons required for the reaction from six to four. The conditions for selectively etching smooth surfaces on (100) are discussed in detail along with the conditions for maintaining polished surfaces on or A‐face, which is difficult with conventional chemical polishes.
Microstructures and Mechanical Properties of Co-Cr Dental Alloys Fabricated by Three CAD/CAM-Based Processing Techniques (2016)

The microstructures and mechanical properties of cobalt-chromium (Co-Cr) alloys produced by three CAD/CAM-based processing techniques were investigated in comparison with those produced by the traditional casting technique. Four groups of disc- (microstructures) or dumbbell- (mechanical properties) specimens made of Co-Cr alloys were prepared using casting (CS), milling (ML), selective laser melting (SLM), and milling/post-sintering (ML/PS). For each technique, the corresponding commercial alloy material was used. The microstructures of the specimens were evaluated via X-ray diffractometry, optical and scanning electron microscopy with energy-dispersive X-ray spectroscopy, and electron backscattered diffraction pattern analysis. The mechanical properties were evaluated using a tensile test according to ISO 22674 (<i>n</i> = 6). The microstructure of the alloys was strongly influenced by the manufacturing processes. Overall, the SLM group showed superior mechanical properties, the ML/PS group being nearly comparable. The mechanical properties of the ML group were inferior to those of the CS group. The microstructures and mechanical properties of Co-Cr alloys were greatly dependent on the manufacturing technique as well as the chemical composition. The SLM and ML/PS techniques may be considered promising alternatives to the Co-Cr alloy casting process.
X-ray Reflectivity of Diblock Copolymer Monolayers at the Air/Water Interface (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTX-ray Reflectivity of Diblock Copolymer Monolayers at the Air/Water InterfaceZ. Li, W. Zhao, J. Quinn, M. H. Rafailovich, J. Sokolov, R. B. Lennox, A. Eisenberg, X. Z. Wu, M. W. Kim, S. K. Sinha, and M. TolanCite this: Langmuir 1995, 11, 12, 4785–4792Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December 1995https://pubs.acs.org/doi/10.1021/la00012a033https://doi.org/10.1021/la00012a033research-articleACS PublicationsRequest reuse permissionsArticle Views351Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Synthesis and Structural Studies of SP and RP Diastereomers of Deoxyxylothymidyl‐3′‐O‐acetylthymidyl (3′,5′)‐O‐(2‐Cyanoethyl)phosphorothioate in Solution and in the Solid State. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Binding of non‐natural 3′‐nucleotides to ribonuclease A (2005)

2'-Fluoro-2'-deoxyuridine 3'-phosphate (dU(F)MP) and arabinouridine 3'-phosphate (araUMP) have non-natural furanose rings. dU(F)MP and araUMP were prepared by chemical synthesis and found to have three- to sevenfold higher affinity than uridine 3'-phosphate (3'-UMP) or 2'-deoxyuridine 3'-phosphate (dUMP) for ribonuclease A (RNase A). These differences probably arise (in part) from the phosphoryl groups of 3'-UMP, dU(F)MP, and araUMP (pK(a) = 5.9) being more anionic than that of dUMP (pK(a) = 6.3). The three-dimensional structures of the crystalline complexes of RNase A with dUMP, dU(F)MP and araUMP were determined at < 1.7 A resolution by X-ray diffraction analysis. In these three structures, the uracil nucleobases and phosphoryl groups bind to the enzyme in a nearly identical position. Unlike 3'-UMP and dU(F)MP, dUMP and araUMP bind with their furanose rings in the preferred pucker. In the RNase A.araUMP complex, the 2'-hydroxyl group is exposed to the solvent. All four 3'-nucleotides bind more tightly to wild-type RNase A than to its T45G variant, which lacks the residue that interacts most closely with the uracil nucleobase. These findings illuminate in atomic detail the interaction of RNase A and 3'-nucleotides, and indicate that non-natural furanose rings can serve as the basis for more potent inhibitors of catalysis by RNase A.
Dose-responses in rat hepatic protein modification and expression following exposure to the rat hepatocarcinogen methapyrilene (1994)

Dose-related effects of methapyrilene (MP) on protein modification and expression were examined using two-dimensional gel electrophoresis (2-D PAGE) coupled with computer analysis. Methapyrilene was administered ad libitum at doses of 0, 62.5, 125, 250 and 1000 p.p.m. to male F-344 rats for 12 weeks beginning at 8 weeks of age. Following treatment, livers were removed and frozen for 2-D PAGE analysis. Separation of hepatic proteins was conducted using ISO-DALT technology. Changes in abundance and modification of hepatic proteins were determined using the Kepler software package. Covalent modifications of three specific mitochondrial proteins were quantified using a charge modification index. Dose-response relationships were analyzed using Tukey's trend test. Results demonstrated that covalent modification of the three mitochondrial proteins was linearly related to dose and that a dose effect could be found at all dose levels in 2 out of 3 proteins. Two forms of change in protein expression were observed: (i) a dose-dependent change with effects at all doses and (ii) a change only at the toxic dose of 1000 p.p.m. MP. These results demonstrate a molecular effect of MP at doses that do not produce cellular responses including toxicity or increases in cell replication suggesting that these specific mitochondrial modifications are molecular dosimeters but are probably not direct factors and/or sufficient factors in carcinogenesis. This study also demonstrates the potential use of 2-D PAGE electrophoresis to delineate the effect of dose on expression of specific proteins.
DA PELEJA DE CEGO ADERALDO COM ZÉ PRETINHO DO TUCUM À PELEJA DE ADERALDO FILHO DO CEGO COM ALEXANDRE O NETO DE ZÉ PRETINHO (2017)

Neste artigo analisamos uma das mais cÃ©lebres pelejas brasileiras, a Peleja de cego Ade raldo com ZÃ© Pretinho do Tucum (1916), de Firmino Teixeira do Amaral, e estudamos tambÃ©m a Peleja de Aderaldo filho do cego, com Alexandre o Neto de ZÃ© Pretinho, de JoÃ£o A. de Barros. Com esta abordagem queremos mostrar que na peleja brasileira (e, em particular, na peleja de cordel) e no mundo que ela representa a lei do mais forte Ã© muitas vezes subvertida. Contra os mais fortes levantam-se os mais fracos, as mulheres, os escravos e outros oprimidos como os cegos, que, pela destreza poÃ©tica e pela forÃ§a anÃ­mica e intelectual, conseguem aproximar-se daqueles que se consideram e dizem mais fortes, e Ã frente deles desmentem e desfazem tabus, preconceitos e fobias.
Discovering Protein Interactions and Characterizing Protein Function Using HaloTag Technology (2014)

Research in proteomics has exploded in recent years with advances in mass spectrometry capabilities that have led to the characterization of numerous proteomes, including those from viruses, bacteria, and yeast. In comparison, analysis of the human proteome lags behind, partially due to the sheer number of proteins which must be studied, but also the complexity of networks and interactions these present. To specifically address the challenges of understanding the human proteome, we have developed HaloTag technology for protein isolation, particularly strong for isolation of multiprotein complexes and allowing more efficient capture of weak or transient interactions and/or proteins in low abundance. HaloTag is a genetically encoded protein fusion tag, designed for covalent, specific, and rapid immobilization or labelling of proteins with various ligands. Leveraging these properties, numerous applications for mammalian cells were developed to characterize protein function and here we present methodologies including: protein pull-downs used for discovery of novel interactions or functional assays, and cellular localization. We find significant advantages in the speed, specificity, and covalent capture of fusion proteins to surfaces for proteomic analysis as compared to other traditional non-covalent approaches. We demonstrate these and the broad utility of the technology using two important epigenetic proteins as examples, the human bromodomain protein BRD4, and histone deacetylase HDAC1. These examples demonstrate the power of this technology in enabling the discovery of novel interactions and characterizing cellular localization in eukaryotes, which will together further understanding of human functional proteomics.
Interactive Deformation Simulation of Manual Girth Measurement for Limbs (2012)

The existing methods for automatic girth measurement are primarily based on 3D point cloud or its generated surfaces, without considering limbs' elasticity and thus the interactive deformation during manual measurement. Taking human foot as example, we propose a new method to simulate manual girth measurement using 3D triangular mesh and mass-spring model. The deformation is limited in the local deformed region consisted of tape region, propagation region and compensation region, while the latter two regions are controlled with depth parameters representing the affected ranges of limb surface from external forces. We also present a novel algorithm to dynamically calculate volume change of the deforming limb, and then repair the lost volume with compensation function. Our approach has the advantages of low computational complexity and realistic volume preserved simulation for interactive deformation in manual measurement. The proposed method is tested with experimental results, which illustrate its efficiency in many applications such as custom products making.
Information capacity of Bragg holograms in planar optics (1981)

The analysis of structural information of planar holograms (i.e., “surface” holograms in integrated optics) is presented by using Ewald’s construction and a grating vector uncertainty theorem. The influences of the geometry and the material constants of the holographic system, the modulation transfer function, and dimensions of the hologram are given. A new approach to the transfer of information, connected with multimode operation, is presented.
Heat Shock Protein Beta-1 Modifies Anterior to Posterior Purkinje Cell Vulnerability in a Mouse Model of Niemann-Pick Type C Disease (2016)

Selective neuronal vulnerability is characteristic of most degenerative disorders of the CNS, yet mechanisms underlying this phenomenon remain poorly characterized. Many forms of cerebellar degeneration exhibit an anterior-to-posterior gradient of Purkinje cell loss including Niemann-Pick type C1 (NPC) disease, a lysosomal storage disorder characterized by progressive neurological deficits that often begin in childhood. Here, we sought to identify candidate genes underlying vulnerability of Purkinje cells in anterior cerebellar lobules using data freely available in the Allen Brain Atlas. This approach led to the identification of 16 candidate neuroprotective or susceptibility genes. We demonstrate that one candidate gene, heat shock protein beta-1 (HSPB1), promoted neuronal survival in cellular models of NPC disease through a mechanism that involved inhibition of apoptosis. Additionally, we show that over-expression of wild type HSPB1 or a phosphomimetic mutant in NPC mice slowed the progression of motor impairment and diminished cerebellar Purkinje cell loss. We confirmed the modulatory effect of Hspb1 on Purkinje cell degeneration in vivo, as knockdown by Hspb1 shRNA significantly enhanced neuron loss. These results suggest that strategies to promote HSPB1 activity may slow the rate of cerebellar degeneration in NPC disease and highlight the use of bioinformatics tools to uncover pathways leading to neuronal protection in neurodegenerative disorders.
ARMC5 Variants and Risk of Hypertension in Blacks: MH‐GRID Study (2019)

Background We recently found that ARMC 5 variants may be associated with primary aldosteronism in blacks. We investigated a cohort from the MH - GRID (Minority Health Genomics and Translational Research Bio-Repository Database) and tested the association between ARMC 5 variants and blood pressure in black s. Methods and Results Whole exome sequencing data of 1377 black s were analyzed. Target single-variant and gene-based association analyses of hypertension were performed for ARMC 5, and replicated in a subset of 3015 individuals of African descent from the UK Biobank cohort. Sixteen rare variants were significantly associated with hypertension ( P=0.0402) in the gene-based (optimized sequenced kernel association test) analysis; the 16 and one other, rs116201073, together, showed a strong association ( P=0.0003) with blood pressure in this data set. The presence of the rs116201073 variant was associated with lower blood pressure. We then used human embryonic kidney 293 and adrenocortical H295R cells transfected with an ARMC 5 construct containing rs116201073 (c.*920T>C). The latter was common in both the discovery ( MH - GRID ) and replication ( UK Biobank) data and reached statistical significance ( P=0.044 [odds ratio, 0.7] and P=0.007 [odds ratio, 0.76], respectively). The allele carrying rs116201073 increased levels of ARMC5 mRNA , consistent with its protective effect in the epidemiological data. Conclusions ARMC 5 shows an association with hypertension in black s when rare variants within the gene are considered. We also identified a protective variant of the ARMC 5 gene with an effect on ARMC 5 expression confirmed in vitro. These results extend our previous report of ARMC 5's possible involvement in the determination of blood pressure in blacks.
DNA Vaccination as Anti—Human Immunodeficiency Virus Immunotherapy in Infected Chimpanzees (1997)

The role of the immune response in controlling human immunodeficiency virus type 1 (HIV-1) replication is controversial. Immunotherapeutic strategies that have the ability to broaden immune responses might play a role in slowing disease progression. DNA immunization was studied as immunotherapy in infected chimpanzees. Two HIV-1-infected chimpanzees were vaccinated with DNA plasmid vaccines, one with plasmid pCMN160, which expresses the envelope glycoprotein of HIV-1MN and rev, and the other with a control plasmid. The chimpanzee immunized with pCMN160 demonstrated enhanced humoral responses. Virus load was monitored. Virus load in the chimpanzee receiving pCMN160 decreased at week 20 and has remained at background levels. The control chimpanzee was subsequently vaccinated with pCMN160. After immunization, the antibody responses increased and, as in the first animal, the virus load decreased. These results indicate the potential of the immune response to have a direct impact on HIV-1 replication in chimpanzees.
Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct (2019)

We identified fusions in PRKACA and PRKACB genes in pancreatic and biliary IOPNs, as well as in PDACs and pancreatic cyst fluid and bile duct cells from the same patients. We did not identify these gene fusions in 126 control pancreatobiliary lesions. These fusions might be used to identify patients at risk for IOPNs and their associated invasive carcinomas.
PI3Kδ inhibition confer efficacy in experimental models of allergic airway inflammation (2015)

Uncontrolled severe asthma is characterized by the generation of allergen-responsive Th2/Th17 memory T cells in lymph nodes, their excessive cytokine production in lung tissue and consequent infiltration of eosinophils and neutrophils from the peripheral circulation. Understanding how and where a potent and selective PI3Kd inhibitor will be maximally efficacious is key to developing effective therapies for severe asthma. To elucidate the pharmacodynamic effects of our highly selective PI3Kd inhibitors on multiple targets of allergic airway inflammation, we compare topical and systemic drug exposures in chronic OVA/alum rats. In addition, we investigated the effect of PI3Kd inhibition on CD4 memory T cells in BAL fluid from the OVA specific, MHC class II restricted αβ T-cell receptor (TCR) OT.2 transgenic mice, by measuring the PI3Kd pathway signaling phosphorylation of S6 ribosomal protein (pS6RP<sup>Ser235/236)</sup>). Therapeutic intervention in the rat OVA/alum model was achieved by dosing on day 20 within the lung challenge phase. Efficacy readouts on day 23 showed elevated Th2 cytokine and granulocyte chemokine levels in BAL, which were reduced dose dependently by PI3Kd inhibition by either route of administration. Consequent influx of eosinophils was also reduced to a comparable degree by either i.t. or i.v. drug. Our results in the OT.2 mice demonstrate the utility of pS6RP<sup>Ser235/236</sup> in CD4+ T cells as a target engagement marker reflecting PI3Kd activity. We also demonstrate the importance of exposure in systemic circulation, regardless of route of administration, to inhibit Th2 signaling and optimally drive efficacy in experimental asthma-related pathophysiology.