gebhart/patrepeval huggingface dataset:
Abstract PO-060: Blood based metabolomic biomarker assay to predict radiation late effects in prostate cancer patients (2021)

Abstract Introduction and Objective: Radiation therapy (RT) is an effective modality as a primary treatment of cancers, or as an adjuvant to surgery or chemotherapy. However, about 10 % of treated patients experience radiation treatment related late effects that adversely affect quality of life. Availability of a blood test that can be used to predict or monitor adverse symptoms would help stratify sensitive sub-populations of patients receiving radiation therapy. We have developed a kit based assay for the measurement of a small molecule based biomarker panel that is predictive of radiation treatment related toxicities in prostate cancer patients. Methods: We performed multiple reaction monitoring based targeted metabolomic/lipidomic analyses using baseline (samples obtained before radiation therapy) from the plasma of a cohort of 100 prostate cancer patients. Pre-processed data along with clinical annotations were used for the analyses. An optimized classifier algorithm was developed, using baseline plasma samples collected prior to the initiation of radiation therapy. We compared groups of sub-sets of patients who developed adverse symptoms to those who did not (control group), over the course of a two-year follow-up interval. Feature selection for building classifiers was performed using LASSO Logistic regression to avoid over-fitting of the model through iterative selection, and cross validation of candidate markers, in compliance with FDA biomarker development guidelines. Results: We have used a combination of metabolomics and clinical data for developing a kit based assay for identification of prostate cancer patients Metabolite signatures predictive of adverse responses to radiation therapy were developed in the patient cohort treated with stereotactic body radiation therapy (SBRT) for prostate cancer. We were able to develop high accuracy, predictive algorithms for recurrence, urinary symptoms and rectal proctitis episodes in this cohort. A plasma metabolite index was developed for the evaluation of susceptibility to adverse outcomes of radiation therapy. Furthermore, a visualization software was developed to integrate clinical and biomarker data for easier clinical translation. Conclusions: We developed candidate predictive biomarker panels that can be used for identifying patients who are at increased risk for developing adverse symptoms following radiation therapy. Following analytical validation, this kit based assay is a candidate for a clinical validation study to determine clinical utility. Citation Format: Amrita K. Cheema, Scott Grindrod, Yaoxiang Li, Shivani Bansal, Simeng Suy, Sean Collins, Anatoly Dritschilo. Blood based metabolomic biomarker assay to predict radiation late effects in prostate cancer patients [abstract]. In: Proceedings of the AACR Virtual Special Conference on Radiation Science and Medicine; 2021 Mar 2-3. Philadelphia (PA): AACR; Clin Cancer Res 2021;27(8_Suppl):Abstract nr PO-060.
Cobalt−Phosphite-Catalyzed Asymmetric Pauson−Khand Reaction (2002)

A complex formed from dicobalt octacarbonyl and a chiral aryl bisphosphite served as a catalyst for the intramolecular asymmetric Pauson-Khand reaction. Bicyclic cyclopentenones were obtained in up to 75% enantiomeric excess. For a terminal 1,6-enyne, the incremental enantiomeric excess was found to increase from 4 to 26% over the course of the reaction. The scope of this process was examined for a variety of 1,6- and 1,7-enynes, and a moderate degree of enantioselectivity was maintained only in the case of aryl-substituted 1,6-enynes.
Metaphor as an Emergent Property of Machine-Readable Dictionaries (1995)

Previous computational attempts to handle non-literal word usage have been restricted to &amp;quot;toy&amp;quot; systems that combine hand-coded lexicons with restricted sets of metaphor types that can be used to sanction specific classes of semantic subcategorization violations. These hand-coded efforts are unlikely to ever scale up to the rigors of real, free text. We describe an example-based approach to metaphor interpretation which exploits a large lexical knowledge base derived from a machine-readable dictionary. We first present an extended example which is meant to demonstrate the scope of evidence about common English metaphors which is encoded in ordinary dictionaries. We then go on to demonstrate how novel instances of metaphor can be interpreted by accessing this information. A given violation of some default semantic expectation can be checked against the LKB to determine whether this violation is an instance of some more systematic mapping of English word meanings from one semantic domain to another. We argue that this approach to metaphor interpretation obviates the need for the traditional &amp;quot;metaphor-handling component &amp;quot; in natural language understanding systems, and will allow these systems to overcome the britdeness of hand-coded approaches.
Optical and Crystalline Properties of Epitaxial-Lateral-Overgrown-GaN Using Tungsten Mask by Hydride Vapor Phase Epitaxy (1999)

The epitaxial lateral overgrowth (ELO) of GaN with a stripe tungsten (W) mask pattern is performed by hydride vapor phase epitaxy (HVPE) and a buried structure of the W mask with a smooth surface is achieved for the stripe mask patterns of &lt;1120&gt; and &lt;1100&gt; direction. Optical and crystalline characteristics of the ELO-GaN are investigated by means of cathodoluminescence (CL) imaging and X-ray rocking curves (XRCs). It is found that the CL intensity at 133 K due to the near-band edge emission is stronger in the laterally overgrown region in comparison with that in the normal growth region. The φ-ω scan of XRCs reveals that the tilting of the c -axis is much smaller in the ELO-GaN grown with the W mask than that grown with an SiO 2 mask.
DEPENDENCE OF KIDNEY MORPHOGENESIS ON THE EXPRESSION OF NERVE GROWTH-FACTOR RECEPTOR (1991)

Nerve growth factor receptor (NGFR) serves as the binding site for the neurotrophic growth factors. Although NGFR has been found in several embryonic tissues outside the nervous system, the function of NGFR in embryogenesis of non-neuronal organs remains unknown. NGFR is transiently synthesized by embryonic rat kidney and disappears from nephrons upon their terminal differentiation. Anti-sense oligonucleotide inhibition of NGFR expression inhibits kidney morphogenesis. Therefore, NGFR is required not only for development of the nervous system, but also for differentiation of the kidney tubules.
Optimal array signal processing in the presence of coherent wavefronts (2002)

The problem of estimating the parameters of several wavefronts from the measurements of multiple sensors is often referred to as array signal processing. The maximum likelihood (ML) estimator in array signal processing for the case of non-coherent signals has been studied extensively. The focus here is on the ML estimator for the case of stochastic coherent signals which arises due to, for example, specular multipath propagation. We show the very surprising fact that the ML estimates of the signal parameters obtained by ignoring the information that the sources are coherent, coincide in large samples with the ML estimates obtained by exploiting the coherent source information. Thus, the ML signal parameter estimator derived for the non-coherent case (or its large-sample realizations such as MODE os WSF) asymptotically achieves the lowest possible estimation error variance (corresponding to the coherent Cramer-Rao bound).
Microfluidic colloidal technologies: From ICT to health applications (2015)

International audience
Municipal wireless data network in Longmont, CO (2008)

As municipalities study opportunities to build large Wi-Fi networks to cover their territory, it is interesting to compare these initiatives' coverage, performance, and cost to other existing cellular high-speed solutions. This paper examines one particular case in the city of Longmont, CO. Coverage and throughput measurements are performed in a residential area; cost analyses and consumer perceptions are examined as well.
Embedded memory and ARM Cortex-M0 core using 60-nm C-axis aligned crystalline indium-gallium-zinc oxide FET integrated with 65-nm Si CMOS (2016)

Low-power embedded memory and an ARM Cortex-M0 core that operate at 30 MHz were fabricated in combination with a 60-nm c-axis aligned crystalline indium-gallium-zinc oxide FET and a 65-nm Si CMOS. The embedded memory adopted a structure in which oxide semiconductor-based 1T1C cells are stacked on Si sense amplifiers. This memory achieved a standby power of 3 nW while retaining data and an active power of 11.7 μW/MHz by making each bitline as short as each sense amplifier. The M0 core adopted the flip-flop in which an oxide semiconductor-based 3T1C cell is stacked on the Si scan flip-flop cell without area overhead and achieved a standby power of 6 nW while retaining data. The combination of the embedded memory and the M0 core provided high-performance, low-power Internet of Things devices operating with a broad range of active standby power ratios.
Data from Randomized Phase II Trial of Polyphenon E versus Placebo in Patients at High Risk of Recurrent Colonic Neoplasia (2023)

&lt;div&gt;Abstract&lt;p&gt;Polyphenon E (Poly E) is a green tea polyphenol preparation whose most active component is epigallocatechin gallate (EGCG). We studied the cancer preventive efficacy and safety of Poly E in subjects with rectal aberrant crypt foci (ACF), which represent putative precursors of colorectal cancers. Eligible subjects had prior colorectal advanced adenomas or cancers, and had ≥5 rectal ACF at a preregistration chromoendoscopy. Subjects (&lt;i&gt;N&lt;/i&gt; = 39) were randomized to 6 months of oral Poly E (780 mg EGCG) daily or placebo. Baseline characteristics were similar by treatment arm (all P &gt;0.41); 32 of 39 (82%) subjects completed 6 months of treatment. The primary endpoint was percent reduction in rectal ACF at chromoendoscopy comparing before and after treatment. Among 32 subjects (15 Poly E, 17 placebo), percent change in rectal ACF number (baseline vs. 6 months) did not differ significantly between study arms (3.7% difference of means; &lt;i&gt;P&lt;/i&gt; = 0.28); total ACF burden was also similar (−2.3% difference of means; &lt;i&gt;P&lt;/i&gt; = 0.83). Adenoma recurrence rates at 6 months were similar by arm (&lt;i&gt;P&lt;/i&gt; &gt; 0.35). Total drug received did not differ significantly by study arm; 31 (79%) subjects received ≥70% of prescribed Poly E. Poly E was well tolerated and adverse events (AE) did not differ significantly by arm. One subject on placebo had two grade 3 AEs; one subject had grade 2 hepatic transaminase elevations attributed to treatment. In conclusion, Poly E for 6 months did not significantly reduce rectal ACF number relative to placebo. Poly E was well tolerated and without significant toxicity at the dose studied.&lt;/p&gt;Prevention Relevance:&lt;p&gt;We report a chemoprevention trial of polyphenon E in subjects at high risk of colorectal cancer. The results show that polyphenon E was well tolerated, but did not significantly reduce the number of rectal aberrant crypt foci, a surrogate endpoint biomarker of colorectal cancer.&lt;/p&gt;&lt;/div&gt;
Scalable video transmission in multiantenna broadcast systems (2008)

In this paper, we make an attempt to integrate the features of scalable video coding (SVC) into current OFDM based mobile communications systems for improving the broadcast data rates and to provide a better coverage. Several physical- and MAC-layer concepts that quality for the use in combination with SVC are evaluated. Space time coding in combination with single carrier frequency division multiplexing (SC-FDM) based on DFT precoding are promising.
Characterization of failure dynamics in SDN controllers (2017)

With Software Defined Networking (SDN) the control plane logic of forwarding devices, switches and routers, is extracted and moved to an entity called SDN controller, which acts as a broker between the network applications and physical network infrastructure. Failures of the SDN controller inhibit the network ability to respond to new application requests and react to events coming from the physical network. Despite of the huge impact that a controller has on the network performance as a whole, a comprehensive study on its failure dynamics is still missing in the state of the art literature. The goal of this paper is to analyse, model and evaluate the impact that different controller failure modes have on its availability. A model in the formalism of Stochastic Activity Networks (SAN) is proposed and applied to a case study of a hypothetical controller based on commercial controller implementations. In case study we show how the proposed model can be used to estimate the controller steady state availability, quantify the impact of different failure modes on controller outages, as well as the effects of software ageing, and impact of software reliability growth on the transient behaviour.
Generation of Recombinant Skin in Vitro by Adeno-Associated Virus Type 2 Vector Transduction (2004)

It has long been recognized that skin may be a particularly good target for pharmacologic gene therapy and as a platform for the secretion of systemically distributed molecules. Adeno-associated virus type 2 (AAV) is a useful vector for skin gene therapy because skin is the natural host tissue for AAV, in which it functions as an autonomous parvovirus. We demonstrate here that recombinant (r) AAV vectors carrying the granulocyte-macrophage colony-stimulating factor (GM-CSF), human papillomavirus E6, or green fluorescent protein (GFP) transgene could transduce primary human keratinocytes in ex vivo culture. We further demonstrate that these transduced cells could be used to form a transgene-positive recombinant skin (r-skin), using the organotypic epithelial raft culture system. Transduction of keratinocytes was demonstrated by reverse transcriptase-polymerase chain reaction (RT-PCR) for RNA expression, enzyme-linked immunosorbent assay (ELISA) for product secretion, intracellular staining for protein expression, vector-chromosomal junction PCR and Southern blot analysis of proviral sequences, in situ immunohistochemistry analysis of protein expression, and ultraviolet light fluorescence for GFP expression. AAV/GM-CSF/Neo-infected keratinocyte/raft skins secreted GM-CSF at levels as high as 25 ng/cm(2) of skin and maintained expression to 60 days postinfection. These data support the utility and efficiency of AAV-based gene delivery to produce genetically altered keratinocytes and r-skin.
Photochemical Electron Transfer Reactions of Tirapazamine¶ (2002)

The absorption and fluorescence spectra of 3-aminobenzo-1,2,4-triazine di-N-oxide (tirapazamine) have been recorded and exhibit a dependence on solvent that correlates with the Dimroth ET30 parameter. Time-dependent density functional theory calculations reveal that the transition of tirapazamine in the visible region is pi-->pi* in nature. The fluorescence lifetime is 98+/-2 ps in water. The fluorescence quantum yield is approximately 0.002 in water. The fluorescence of tirapazamine is efficiently quenched by electron donors via an electron-transfer process. Linear Stern-Volmer fluorescence quenching plots are observed with sodium azide, potassium thiocyanate, guanosine monophosphate and tryptophan (Trp) methyl ester hydrochloride. Guanosine monophosphate, tyrosine (Tyr) methyl ester hydrochloride and Trp methyl ester hydrochloride appear to quench the fluorescence at a rate greater than diffusion control implying that these substrates complex with tirapazamine in its ground state. This complexation was detected by absorption spectroscopy.
Computational analysis of solo versus ensemble performance in string quartets: intonation and dynamics (2012)

Comunicació presentada a la conferència conjunta que inclou la 12th International Conference on Music Perception and Cognition (ICMPC) i la 8th Triennial Conference of the European Society, celebrada a Tessalònica (Grècia) els dies 23 a 28 de juliol de 2012.
Field Demonstration of a Real-time Non-intrusive Monitoring System for Condition-based Maintenance (2009)

The performance of important electrical loads on mission critical systems like warships or off-shore platforms is often tracked by dedicated monitoring equipment. Individual monitoring of each load is expensive and risky. Expense occurs because of the need for individual sensors and sensor wiring for every load of interest. Reliability is compromised because detected failures or fault conditions might legitimately be due to load failure, but might also be due to errors or failure in the sensor network or recording instruments. The power distribution network on a warship could be pressed into “dual-use” service, providing not only power distribution but also a diagnostic monitoring capability based on observations of the way in which loads draw power from the distribution service. This paper describes field tests of a prototype system that monitors multiple loads using existing electrical wiring. Initial results are presented from a device that monitors a small collection of motors and two other devices that monitor an entire engine room.
Radar cross-section prediction based on shooting and bouncing rays using line tracing method (2014)

High-frequency predictions of radar cross-sections are usually performed using the well-known shooting and bouncing rays (SBR) method. SBR needs many incident ray tubes for accurate results. Therefore, its computation time is proportional to the square of the number of ray tubes, often resulting in a prohibitively large computation time, especially for electrically large and complex objects. To address this problem, a new ray tube merging scheme called line tracing SBR (LT-SBR) is proposed to reduce the number of incident rays. Simulation results reveal that the LT-SBR has a computational advantage over the conventional SBR and recently introduced beam tracing SBR.
Analysis of Silicon Germanium Standards for the Quantification of SiGe Microelectronic Devices Using AES (2015)

Four samples of well-defined silicon-germanium alloys were used as standards for calibration purposes to allow accurate quantification of silicon-germanium-on-insulator (SGOI) microelectronic devices using Auger electron spectroscopy. Narrow Si KLL and the Ge LMM, high resolution Si KL2,3L2,3 and Ge L3M4,5M4,5 together with survey spectra were collected and are presented from each sample. A matrix effect was observed for silicon in germanium and calculated as 0.85 and 0.95 for the Ge77.5Si22.5 and Ge52.4Si47.6 alloys respectively.
Exploration and Field Study of a Browser-based Password Manager using Icon-based Passwords ? (2011)

Abstract. We carry out a hybrid lab and field study of a password manager program, and report on usability and security. Our study explores iPMAN, a browser-based password manager that in addition uses a graphical password scheme for the master password. We present our findings as a set of observations and insights expected to be of interest both to those exploring password managers, and graphical passwords. Motivated by our findings, but also of independent interest, we also present a new salt generation method using blind signatures, to protect against offline attacks, decreasing user inconvenience by generating salt significantly faster than earlier work (Halderman et al. 2005).
Polar modulation-based RF power amplifiers with enhanced envelope processing technique (2004)

This research aims to develop high-eficiency Linear RF power amplifier using polar modulation technique. In our proposed architecture, the in-phase and quadraturephase components of baseband signal are transformed into the envelope and phase components in the digital domain. The envelope component is tben delta-sigma modulated to drive a DC-to-DC converter. After filtering, the analog envelope signal has been amplified to modulate the phasemodulated carrier using a saturated power amplifier. The experimental results show that such a polar modulationbased RF power amplifier with proposed envelope processing technique has great potential to deal with highpower amplification of digital modulation carriers with time-varying envelope highly efficiently.
Magnetic Separation on a New Level: Characterization and Performance Prediction of a cGMP Compliant “Rotor‐Stator” High‐Gradient Magnetic Separator (2017)

The growing market of biopharmaceuticals and the constant developments in upstream fermentation have generated a strong demand for new downstream purification methods. Magnetic separation in combination with functional magnetic particles has been known for many years as a promising candidate for a direct capturing tool in protein purification but the lack of suitable GMP-compliant purification equipment has prevented the launch of this technology in large scale bioprocessing. To tackle this bottle-neck, the principle of a "rotor-stator" high-gradient magnetic separator is fully redesigned to meet the rigorous requirements of modern cGMP biotechnology purification processes. In order to fulfill regulatory requirements, the separation chamber is reengineered to allow effective cleaning and sterilization in place while maintaining excellent separation capacities and efficiencies. Two kinds of commercially available magnetic particles are used to validate key performance data and determine system related parameters in order to calculate process performance figures for process optimization of the new magnetic separation device. With separation capacities of over 400 g of magnetic particles per liter of separation chamber volume and separation efficiencies as well as recovery rates over 99%, the system is able to process more than 200 l crude feedstock per day and capture more than 1.6 kg target compounds.
Large-scale characteristics of plate boundary deformations related to the post-seismic readjustment of a thin asthenosphere (1982)

The large-scale response of an elastic lithosphere, riding on a ‘thin’ viscoelastic asthenosphere, to periodically occurring ruptures at a transform or subduction-type plate boundary is described approximately by appropriate limit cycle solutions for a plate/foundation model introduced previously by Rice. The cyclic behaviour of thickness-averaged displacements, strains and strain rates, their decay away from the plate boundary, and a resolution into coseismic and post-seismic alterations are obtained and their dependence on repeat time and a characteristic relaxation time investigated. A comparison is made with existing periodic solutions for the surface deformations in a Nur—Mavko half-space model. This suggests important effects due to viscosity stratification on post-seismic rebound when earthquake repeat × exceed relevant relaxation × by at least one order of magnitude.
Direct Solution of Scattering Problems Using Generalized Source Integral Equations (2020)

A class of inherently compressible integral equation formulations for problems of scattering by impenetrable objects, which makes use of generalized directional sources, is presented. The new formulation effectively reduces the problem's dimensionality and, thus, allows for efficient low-rank compression of moment matrices' off-diagonal blocks. When the formulation is used with a hierarchical matrix compression and factorization algorithm, a fast direct solver is obtained. The computational bottlenecks introduced by the proposed generalized formulation, in both the matrix-fill and matrix compression stages, are alleviated by using nonuniform sampling-based techniques. These techniques are described in detail for one choice of generalized sources, which use absorbing equivalent source shields, and can be extended to other shield types. The formulation's properties and limitations are studied and its enhanced compressibility is used for the development of a fast direct solver.