gebhart/patrepeval huggingface dataset:
Table S5 from Intertumoral Heterogeneity of CD3<sup>+</sup> and CD8<sup>+</sup> T-Cell Densities in the Microenvironment of DNA Mismatch-Repair–Deficient Colon Cancers: Implications for Prognosis (2023)

&lt;p&gt;Table S5. Identification of optimal cutpoint in CD3+ T-cell densities at the invasive margin (CD3+IM) to distinguish overall survival in mismatch repair-proficient stage IIII colon cancers&lt;/p&gt;
Asynchronous Stochastic Decoding of Low-Density Parity-Check Codes (2012)

This paper presents an asynchronous scheduling algorithm for high-throughput stochastic low-density parity-check (LDPC) decoders. Stochastic computation provides ultra-low-complexity hardware and can be implemented using binary or multiple-valued logic gates. Using asynchronous control, it also eliminates a global clock signal and therefore eases the worst-case timing restrictions. A timing model of asynchronous-computation behaviours under a 90nm CMOS technology is used to demonstrate that the proposed algorithm with an optimized computation delay properly decodes a regular (1024, 512) LDPC code without the "lock-up" problem that potentially stops decoding before convergence and hence causes loss in coding gain. Based on our models, the proposed scheme achieves up to 7.37x improvement in decoding throughput with comparable BER performance in comparison with performance results of a conventional synchronous stochastic decoder.
Systemic delivery of TNF-armed myxoma virus plus immune checkpoint inhibitor eliminates lung metastatic mouse osteosarcoma (2021)

Solid cancers that metastasize to the lungs represent a major therapeutic challenge. Current treatment paradigms for lung metastases consist of radiation therapy, chemotherapies, and surgical resection, but there is no single treatment or combination that is effective for all tumor types. To address this, oncolytic myxoma virus (MYXV) engineered to express human tumor necrosis factor (vMyx-hTNF) was tested after systemic administration in an immunocompetent mouse K7M2-Luc lung metastatic osteosarcoma model. Virus therapy efficacy against pre-seeded lung metastases was assessed after systemic infusion of either naked virus or <i>ex vivo</i>-loaded autologous bone marrow leukocytes or peripheral blood mononuclear cells (PBMCs). Results of this study showed that the PBMC pre-loaded strategy was the most effective at reducing tumor burden and increasing median survival time, but sequential intravenous multi-dosing with naked virus was comparably effective to a single infusion of PBMC-loaded virus. PBMC-loaded vMyx-hTNF also potentially synergized very effectively with immune checkpoint inhibitors anti-PD-1, anti-PD-L1, and anti-cytotoxic T lymphocyte associated protein 4 (CTLA-4). Finally, in addition to the pro-immune stimulation caused by unarmed MYXV, the TNF transgene of vMyx-hTNF further induced the unique expression of numerous additional cytokines associated with the innate and adaptive immune responses in this model. We conclude that systemic <i>ex vivo</i> virotherapy with TNF-α-armed MYXV represents a new potential strategy against lung metastatic cancers like osteosarcoma and can potentially act synergistically with established checkpoint immunotherapies.
ChemInform Abstract: Cycloaddition of the Anion Derived from Homophthalic Anhydride to cis,cisoid,cis‐Tricyclo(6.3.0.02,6)undeca‐4,9‐diene‐3,11‐dione. Aromatization as a Driving Force for Intramolecular Sigmatropic Hydrogen Transfer. (1989)

Abstract The (4 + 2)cycloaddition reaction of the salt (III), derived from homophthalic anhydride (I), with the unsaturated tricyclic diketone (IV) yields the naphthol (V) via decarboxylation and subsequent intramolecular hydrogen migration.
Loss of monotonicity and anomalous scaling behavior in the passive scalar gradient (2013)

Purpose The purpose of this paper is to discuss some fundamental aspects regarding the anomalies in the passive scalar field advected by forced homogenous and isotropic turbulence, by inspection of the analytical properties of the governing equations and with the aid of direct numerical simulation (DNS) data. Design/methodology/approach Results from a pseudo‐spectral DNS of a unitary‐Schmidt‐ number passive scalar advected by a low Reynolds number flow field, Re λ =50 and 70 (based on the Taylor microscale λ ) allow for a preliminary assessment of the developed numerical model. Findings Manipulation of the governing equations for the scalar field (which are monotonic) reveals that the unboundedness of the scalar gradient magnitude is not ruled out by the mathematical properties of the correspondent conservation equation. Classic intermittency effects in the passive scalar field have been reproduced, such as non‐Gaussian behavior of the passive scalar statistics, loss of local isotropy, and multi‐fractal scaling of scalar structure functions. Moreover, Taylor and Richardson theories are, surprisingly, not confirmed only in the dissipation range (small‐scales anomalies). Originality/value The authors suggest that the origin of intermittency (qualitatively pictured here as violent burst in spatial gradient quantities) should be sought in the loss of monotonicity of the evolution equation of the scalar gradient.
QoS Control of Real-Time Data Services under Uncertain Workload (2007)

Real-time systems comprise computers that must generate correct results in a timely manner. This involves a wide spectrum of computing systems found in our everyday life ranging from computers in rockets to our mobile phones. The criticality of producing timely results defines the different types of realtime systems. On one hand, we have the so-called hard real-time systems, where failing to meet deadlines may result in a catastrophe. In this thesis we are, however, concerned with firm and soft real-time systems, where missing deadlines is acceptable at the expense of degraded system performance. The usage of firm and soft real-time systems has increased rapidly during the last years, mainly due to the advent of applications in multimedia, telecommunication, and e-commerce. These systems are typically data-intensive, with the data normally spanning from low-level control data, typically acquired from sensors, to high-level management and business data. In contrast to hard real-time systems, the environments in which firm and soft real-time systems operate in are typically open and highly unpredictable. For example, the workload applied on a web server or base station in telecommunication systems varies according to the needs of the users, which is hard to foresee. In this thesis we are concerned with quality of service (QoS) management of data services for firm and soft real-time systems. The approaches and solutions presented aim at providing a general understanding of how the QoS can be guaranteed according to a given specification, even if the workload varies unpredictably. The QoS specification determines the desired QoS during normal system operation, and the worst-case system performance and convergence rate toward the desired setting in the face of transient overloads. Feedback control theory is used to control QoS since little is known about the workload applied on the system. Using feedback control the difference between the measured QoS and the desired QoS is formed and fed into a controller, which computes a change to the operation of the real-time system. Experimental evaluation shows that using feedback control is highly effective in managing QoS such that a given QoS specification is satisfied. This is a key step toward automatic management of intricate systems providing real-time data services.
GSK-3b inhibition: At the crossroad between Akt and mTOR constitutive activation to enhance cyclin D1 protein stability in mantle cell lymphoma (2008)

Strategies able to downregulate the aberrant expression of cyclin D1 may prove of therapeutic relevance in cancer patients. This is particularly true for mantle cell lymphoma (MCL) in which cyclin D1 is overexpressed as a consequence of the t(11;14)(q13;q32) translocation. We have recently demonstrated that an increased cyclin D1 stability also contributes to the high levels of this protein observed in MCL cells. This effect is mediated by a constitutive activation of PI3-K/Akt, which keeps GSK-3beta inhibited. Here we show that inhibition of PI3-K/Akt induces a 40% decrease of cyclin D1 half-life as a result of accumulation of the dephosphorylated/active form of GSK-3beta within the nucleus, where this kinase can phosphorylate cyclin D1 on Thr286 thereby promoting its nuclear export. Translocation of cyclin D1 into the cytoplasm is mediated by the nuclear exportin CRM1, whose association with cyclin D1 increases following PI3-K/Akt inhibition. Notably, rapamycin downregulated GSK-3beta Ser9 phosphorylation with concurrent nuclear export of cyclin D1 only in MCL cells in which GSK-3beta is under the control of mTOR. These findings suggest that the ability to downregulate cyclin D1 through GSK-3beta may identify subsets of MCL patients who may benefit from the treatment with mTOR inhibitors and stimulate further studies to assess whether the inability to affect GSK-3beta activity may constitute a clinically relevant resistance factor to mTOR inhibitors.
Specific regions of the extracellular domain of DLK an EGF-like homeotic protein involved in differentiation participate in intramolecular interactions (2001)

The level of expression of dlk, an EGF-like protein possessing six EGF-like repeats in its extracellular region, is critical for 3T3-L1 fibroblasts to differentiate into adipocytes in response to IGF1. The mechanism of action of dlk is not well understood, but its localization on the cell membrane suggests that dlk may function as a receptor, as a ligand or as a regulatory protein modulating the binding, the signaling, or the expression of other molecules involved in cell differentiation and growth. In this work, we demonstrate, by using the Yeast Two-Hybrid system, that dlk interacts with itself through specific regions of its extracellular domain. The strongest interactions were observed between specific EGF-like repeats and between a non EFG-like region where unknown proteases act to generate soluble forms of dlk. These observations suggest that the interaction between two membrane dlk molecules belonging to the same or to different cells, or the interaction between soluble and membrane dlk variants, may be important to regulate dlk function.
Positive Tone, Polynorbornene Dielectric Crosslinking (2014)

The processing and properties of a positive-tone, aqueous develop, epoxy crosslinked permanent dielectric based on a polynorbornene (PNB) backbone and bis(diazonaphthoquinone) (DNQ) photosensitive compound were investigated. The developing and cure properties of the films were studied as a function of cure temperature, epoxy crosslinker loading and DNQ loading. Reduced modulus measurements showed that crosslinking of the polymer film occurred via reaction of the polymer with DNQ. The final modulus of the DNQ-crosslinked film was 4.0 GPa. Swelling measurements for a UV exposed film showed material leaching from the film. Residual solvent from swelling measurements was analysed by gel permeation chromatography which showed the indene carboxylic acid form of DNQ leached out of the polymer film. The unexposed film did not exhibit material loss through leaching. When developed, films showed a decline in modulus to 2.6 GPa, likely due to the reaction of DNQ with the aqueous base developer forming nonreactive byproducts that did not contribute to crosslinking. An epoxy crosslinker was added to the formulation which helped crosslink the polymer film by inhibiting uptake of the aqueous base during developing. The epoxy inhibition of the base uptake was confirmed by quartz crystal microbalance, where an increase in epoxy loading led to a decrease in base uptake of the film during developing. 19F-NMR results support the DNQ-PNB crosslinking through esterification. Electrical characterization of the cured PNB films showed a relative dielectric constant of 3.65 for a DNQ and epoxy containing film after curing at 220◦C.
TWEAK-Fn14 Signaling Activates Myofibroblasts to Drive Progression of Fibrotic Kidney Disease (2016)

The identification of the cellular origins of myofibroblasts has led to the discovery of novel pathways that potentially drive myofibroblast perpetuation in disease. Here, we further investigated the role of innate immune signaling pathways in this process. In mice, renal injury-induced activation of pericytes, which are myofibroblast precursors attached to endothelial cells, led to upregulated expression of TNF receptor superfamily member 12a, also known as fibroblast growth factor-inducible 14 (Fn14), by these cells. In live rat kidney slices, administration of the Fn14 ligand, TNF-related weak inducer of apoptosis (TWEAK), promoted pericyte-dependent vasoconstriction followed by pericyte detachment from capillaries. In vitro, administration of TWEAK activated and differentiated pericytes into cytokine-producing myofibroblasts, and further activated established myofibroblasts in a manner requiring canonical and noncanonical NF-κB signaling pathways. Deficiency of Fn14 protected mouse kidneys from fibrogenesis, inflammation, and associated vascular instability after in vivo injury, and was associated with loss of NF-κB signaling. In a genetic model of spontaneous CKD, therapeutic delivery of anti-TWEAK blocking antibodies attenuated disease progression, preserved organ function, and increased survival. These results identify the TWEAK-Fn14 signaling pathway as an important factor in myofibroblast perpetuation, fibrogenesis, and chronic disease progression.
Successful Resuscitation From Cardiac Arrest Using High-Dose Epinephrine Therapy (1988)

A patient with cardiac arrest failed to respond to prolonged standard therapy for multiple dysrhythmias. High-dose intravenous epinephrine hydrochloride was administered 22 and 26 minutes after arrest. Coarsening of ventricular fibrillation and defibrillation with subsequent return of spontaneous circulation occurred. The patient was neurologically intact when eventually discharged. In another patient, prolonged asystole failed to respond to standard advanced cardiac life-support therapy. High-dose epinephrine was given 38 minutes after arrest, and return of spontaneous circulation subsequently occurred. Intensive treatment efforts were discontinued after admission to the hospital, and the patient died. The temporal sequence in these patients suggests that high-dose epinephrine therapy caused the return of spontaneous circulation. Recent studies suggest that presently recommended epinephrine doses may be too low, and investigation of graded epinephrine doses for the treatment of cardiac arrest is indicated.
Safety and efficacy of ketoconazole (K) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC): Contemporary experience and prognostic indicators. (2011)

e15007 Background: Intracrine conversion of adrenal androgens to testosterone play an important role in CRPC progression. Treatments (tx) that block adrenal steroid synthesis have shown significant clinical benefits in mCRPC. Aim: To evaluate contemporary data on safety and efficacy associated with K in mCRPC. Methods: All/unselected mCRPC pts progressing on GnRH-a and antiandrogens (AA) treated with K were retrospectively analyzed. Pts were maintained on gonadal suppression, discontinued AA, and received K 200 - 400 mg t.i.d. until disease progression or dose-limiting toxicity (DLT). Initial 600mg/d dose was escalated to 1200mg/d if a PSA decrease was not seen at 3 months (mos) or if a subsequent disease progression was observed (optional). Follow up included hematological/chemical profile q 3 mos, scans upon clinical (physical exam/symptoms) or biochemical progression (PSA increase ≥ 25% and ≥2ng/ml from nadir). A multivariate cox regression model was used to identify variables significantly associated with disease progression. Results: From 1999-2010 (mean follow up 5-129 mos), 114 m-CRPR pts were treated with K 200mg (n=82, 72%) or 400mg (n=32, 28%) tid. Most common grade 3/4 tox events (n=23) were fatigue, abdominal discomfort, nausea, and dizziness. 9 pts (8%) had DLT (fatigue n=7, hepatotoxicity/thrombocytopenia n=1). 61/114 (54%) had ≥ 50% PSA decline. Overall median time to progression (TTP) was 8 mos (range 1-129 ). 14 pts remain progression free > 7 mos (range 7-129). Significant prognostic factors (Table) were response to prior AA (≥6 vs. <6 mos), pre-tx PSADT (≥3 vs. <3 mos) and extent of disease (limited-axial skeleton and/or nodal vs extensive- appendicular skeleton and/or visceral). Conclusions: K is effective and safe in m-CRPC. Prior response to AA, pre-tx PSADT, and extent of disease are associated with TTP and further supports a therapeutic role for suppressing adrenal androgens in m-CRPC. Factor TTP (mos), HR, p value Response to prior AA of ≥6 vs. <6 mos duration 18 vs. 3, 3.522, 0.0019 Pre-tx PSADT ≥3 vs. <3 ms 16 vs. 4, 1.725, 0.049 Limited vs. extensive metastatic disease 19 vs. 5, 2.12, 0.018
New In-pile Instrumentation to Support Fuel Cycle Research and Development (2011)

New and enhanced nuclear fuels are a key enabler for new and improved reactor technologies. For example, the goals of the next generation nuclear plant (NGNP) will not be met without irradiations successfully demonstrating the safety and reliability of new fuels. Likewise, fuel reliability has become paramount in ensuring the competitiveness of nuclear power plants. Recently, the Office of Nuclear Energy in the Department of Energy (DOE-NE) launched a new direction in fuel research and development that emphasizes an approach relying on first principle models to develop optimized fuel designs that offer significant improvements over current fuels. To facilitate this approach, high fidelity, real-time, data are essential for characterizing the performance of new fuels during irradiation testing. A three-year strategic research program is proposed for developing the required test vehicles with sensors of unprecedented accuracy and resolution for obtaining the data needed to characterize three-dimensional changes in fuel microstructure during irradiation testing. When implemented, this strategy will yield test capsule designs that are instrumented with new sensor technologies for the Advanced Test Reactor (ATR) and other irradiation locations for the Fuel Cycle Research and Development (FC R&D) program. Prior laboratory testing, and as needed, irradiation testing, of these sensors will have been completed to give sufficient confidence that the irradiation tests will yield the required data. Obtaining these sensors must draw upon the expertise of a wide-range of organizations not currently supporting nuclear fuels research. This document defines this strategic program and provides the necessary background information related to fuel irradiation testing, desired parameters for detection, and an overview of currently available in-pile instrumentation. In addition, candidate sensor technologies are identified in this document, and a list of proposed criteria for ranking these technologies. A preliminary ranking of candidate technologies is performed to illustrate the path forward for developing real-time instrumentation that could provide the required data for the FC R&D program. This draft document is a starting point for discussion with instrumentation experts and organizations. It is anticipated that the document will be used to stimulate discussions on a wide-range of sensor technologies and to gain consensus with respect to the path forward for accomplishing the goals of this research program.
Terroir of yeasts? – Application of FTIR spectroscopy and molecular methods for strain typing of yeasts (2015)

The site specific influence on wine (Terroir) is an often by wine producers, consumers and scientists discussed topic in the world of wine. A study on grapes and (spontaneous) fermentations from six different vineyards was done to investigate the biodiversity of yeasts and to answer the question if there is a terroir of yeast and how it could be influenced. Randomly isolated yeasts were identified by FTIR-spectroscopy and molecular methods on species and strain level. Vineyard specific yeast floras would be observed but they are not such important as expected. Only a few overlapping strain patterns would be identified during both vintages. The yeast flora of the winery had a huge impact on the spontaneous fermentations, but is not really constant and influenced by different factors from outside.
Composite Consensus-Building Process: Permissible Meeting Analysis and Compromise Choice Exploration (2022)

In solving today's social issues, it is necessary to determine solutions that are acceptable to all stakeholders and collaborate to apply them. The conventional technology of "permissive meeting analysis" derives a consensusable choice that falls within everyone's permissible range through mathematical analyses; however, it tends to be biased toward the majority in a group, making it difficult to reach a consensus when a conflict arises. To support consensus building (defined here as an acceptable compromise that not everyone rejects), we developed a composite consensus-building process. The developed process addresses this issue by combining permissible meeting analysis with a new "compromise choice-exploration" technology, which presents a consensusable choice that emphasizes fairness and equality among everyone when permissible meeting analysis fails to do so. When both permissible meeting analysis and compromise choice exploration do not arrive at a consensus, a facility is provided to create a sublated choice among those provided by them. The trial experimental results confirmed that permissive meeting analysis and compromise choice exploration are sufficiently useful for deriving consensusable choices. Furthermore, we found that compromise choice exploration is characterized by its ability to derive choices that control the balance between compromise and fairness. Our proposed composite consensus-building approach could be applied in a wide range of situations, from local issues in municipalities and communities to international issues such as environmental protection and human rights issues. It could also aid in developing digital democracy and platform cooperativism.