gebhart/patrepeval huggingface dataset:
The Plk-1 Inhibitor BI 2536 Counteracts the Growth of Neoplastic Mast Cells and Synergizes with the KIT D816V-Targeting Drug Midostaurin (PKC412) in Producing Growth-Inhibition. (2007)

Abstract Systemic mastocytosis (SM) is a myeloid neoplasm characterized by abnormal growth and accumulation of mast cells (MC) in various internal organs. In most patients, the D816V-mutated variant of c-KIT, which mediates resistance against several tyrosine kinase (TK) inhibitors like imatinib, is found. In advanced SM, the response of neoplastic MC to conventional drugs is poor and the prognosis is grave. Therefore current research is attempting to identify novel targets in neoplastic MC. Polo-like kinase 1 (Plk-1) is a serine/threonine kinase that plays an essential role in mitosis and has recently been introduced as a new target in myeloid leukemias. In the present study, we analyzed expression and function of Plk-1 in neoplastic human MC, and asked whether Plk-1 can serve as a target of therapy in SM. As determined by immunohistochemistry, primary neoplastic MC were found to display activated/phosphorylated Plk-1 in all patients examined (n=5). The human MC leukemia cell line HMC-1 was also found to exhibit activated Plk-1. In addition, we found that primary neoplastic MC as well as HMC-1 cells express Plk-1 mRNA in RT-PCR experiments. As assessed by 3H-thymidine-uptake experiments, the Plk-1-targeting drug BI 2536 (Boehringer Ingelheim GmbH, Germany) was found to inhibit the proliferation of HMC-1 cells in a dose-dependent manner (IC50 5–15 nM). The effect of BI 2536 was seen in both subclones of HMC-1, i.e. in HMC-1.1 cells displaying KIT G560V (but not KIT D816V), and HMC-1.2 cells exhibiting both KIT G560V and KIT D816V, with comparable IC50 values. Moreover, BI 2536 was found to inhibit the proliferation of primary neoplastic cells, with IC50 values ranging between 5 and 50 nM. The growth-inhibitory effects of BI 2536 on HMC-1 cells were found to be associated with mitotic arrest and G2-M cell cycle arrest as well as consecutive apoptosis. In normal bone marrow or peripheral blood mononuclear cells, neither mitotic cell arrest nor apoptosis were observed after treatment with BI 2536. In a consecutive phase of the study, we asked whether combined targeting of KIT D816V and Plk-1 would lead to synergistic drug-interactions. For this purpose, HMC-1 cells and primary neoplastic MC were coincubated with BI 2536 and midostaurin (PKC412), a multitargeted kinase inhibitor that blocks KIT D816V TK activity. In these experiments, BI 2536 was found to synergize with midostaurin in counteracting the proliferation of HMC-1 cells and primary neoplastic MC. In conclusion, our data show that activated Plk-1 is detectable in MC neoplasms and plays a role in cell cycle progression and viability of neoplastic MC. Targeting of Plk-1 with BI 2536 leads to growth inhibition and apoptosis in neoplastic MC. Furthermore, BI 2536 synergizes with midostaurin in counteracting growth of neoplastic MC. Targeting of Plk-1 may be an attractive new pharmacologic concept in advanced SM.
Exploring the Value of Open Source in SI Engine Control (2011)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The notion of open source systems has been well established in systems software and typified by the development of the Linux operating system. An open source community is a community of interest that makes use of software tools in research and development. Their ongoing development is part of the free flow of ideas on which the community. The motivation for the work reported in this paper is to provide the research community in engine controls with a ready access to a complete engine management solution and the component parts.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;The work described in this paper extends open source principles to engine control with a portable spark ignition (SI) control strategy assembled using Simulink. The underlying low level drivers are written in C and designed for portability. A calibration tool is written in C and works over a controller area network (CAN) link to the engine control unit (ECU).&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;The ECU hardware is based on the Infineon Tricore microcontroller. In the first implementation, the strategy was developed on the Infineon Powertrain Starter Kit (PSK) hardware. During the course of the work, the same strategy was implemented on the GEMS-K1, another Tricore based system developed by Tianjin University, People's Republic of China.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;The reported work has made use of the Ford Zetec 1.41 engine on which practical tests have been conducted and a simple bench top spinning rig that allowed the timing functions of the systems to be developed.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt; The paper describes three mini-projects, each of which tests the capability of our system to support short duration and technically rich developments. In the first of the projects, an implementation of an &lt;i&gt;extremum&lt;/i&gt; control has been tested in order to demonstrate the potential to automatically identify optimum spark timing on-line. In the second a knock detection algorithm and a simple control algorithm is developed that utilises the digital signal processing (DSP) functions of the target microcontroller. In the third individually estimated air to fuel ratio (AFR) values for the cylinders of a spark ignition engine are estimated from a single universal exhaust gas oxygen (UEGO) sensor output. &lt;/div&gt;&lt;/div&gt;
Time-resolved identification of modes and measurement of intermodal dispersion in optical fibers (1992)

Picosecond pulses from a tunable mode-locked visible dye laser are injected into a 603-m few-mode optical fiber. Measurements of the output power temporal profile with 35-ps resolution show six clearly resolved modes. Time-profile measurements over a two-dimensional array of points in the fiber output far field yield a picture of each mode that identifies it. Measurements as a function of wavelength and fitting to waveguide dispersion calculations are used to model the fiber core refractive-index profile. As a result for the nominal step-index fiber used in this work, the presence of an index dip at the center of the core was detected.
Cyclic failure analysis of sternal fixation techniques (2006)

The aim of this study was to test the hypothesis that sternal fixation failure occurs as a result of the repetitive cyclic loading of low loads as opposed to instantaneous loading of high forces which have been studied elsewhere. To achieve this aim, samples of bisected porcine sternum were reapproximated and fixed using wires or plates and subjected to cyclic application of low magnitude forces to simulate breathing. Cortical and cancellous screw-plate fixation systems were compared, and traditional, simple straight wiring was used as a control. A servohydraulic testing system was used to apply low forces (67N±22N,~ 15 lbs) at low frequency (2 Hz) for a high number of cycles (~50,000) and displacement between the sternal halves was monitored by an extensometer.
Halogenated adamantanes: intermolecular interactions in the solid state. X-ray structures of difluorodiiodo-, trifluoroiodo- and tetraiodoadamantane (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHalogenated adamantanes: intermolecular interactions in the solid state. X-ray structures of difluorodiiodo-, trifluoroiodo- and tetraiodoadamantaneMatthias Bremer, Peter S. Gregory, and Paul v. R. SchleyerCite this: J. Org. Chem. 1989, 54, 16, 3796–3799Publication Date (Print):August 1, 1989Publication History Published online1 May 2002Published inissue 1 August 1989https://pubs.acs.org/doi/10.1021/jo00277a012https://doi.org/10.1021/jo00277a012research-articleACS PublicationsRequest reuse permissionsArticle Views152Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Design, Synthesis, and Evaluation of Novel, Highly CO2-Soluble Chelating Agents for Removal of Metals (1996)

The environmentally benign nature of CO2 and the ever-increasing regulations on the use of conventional solvents present CO2 as a solvent of choice for extraction processes for remediation of contaminated media, as a substitute for CFCs in precision cleaning processes, etc. However, because of the low solubility of metal ions and conventional metal chelating agents, there has been only limited progress in use of CO2 as a solvent in the extraction of metals. Consequently, we have embarked on the molecular design and synthesis of several novel, highly CO2-soluble chelating agents. This paper describes the synthesis and evaluation of these chelating agents that exhibit solubilities in excess of 100 mmol/L of CO2 at room temperature and pressures of 1100−2000 psi and extract as much as 98% of metals such as mercury, lead, arsenic, chromium, and iron from various matrices in laboratory-scale extractions that use pure CO2 as the solvent.
Idiopathic Sclerosing Inflammation Presenting as Sinusitis (2012)

Idiopathic sclerosing orbital inflammation is a rare finding that is poorly delineated, immune mediated, and causes severe symptoms and disability. It has been described affecting the orbit in addition to other sites within the head and neck, but has rarely been described presenting as sinusitis. A case report and literature review were performed. A 14-year-old girl with right-sided face and eye pain and pressure for >1 month presented 3 days after endoscopic sinus surgery for presumed acute sinusitis. She subsequently developed ipsilateral vision loss and hypesthesia of the infraorbital nerve. MRI revealed a mildly enhancing soft tissue intensity lesion extending from the right maxillary sinus into the pterygopalatine fossa and orbital apex through the inferior orbital fissure. Biopsy specimens of the lesion were consistent with a sclerosing inflammatory lesion. High-dose steroids led to rapid improvement in vision and pain; however, the patient was unable to tolerate steroid weaning because of recurrence of eye pain and headache. Repeat imaging showed progression of the lesion. Rheumatology was consulted and the patient's steroid therapy was altered and her medications were expanded to include azathioprine. The patient's symptoms improved and subsequent imaging showed a reduction in the size and extent of the lesion. Idiopathic sclerosing inflammation is characterized by primary, chronic, and immunologically mediated fibrosis. Patients typically have a poor response to corticosteroid treatment or radiotherapy. Immunosuppressive therapy in addition to corticosteroids is the recommended treatment.
Expression of a beta 1-related integrin by oligodendroglia in primary culture: evidence for a functional role in myelination (1994)

We have investigated the expression of integrins by rat oligodendroglia grown in primary culture and the functional role of these proteins in myelinogenesis. Immunochemical analysis, using antibodies to a number of alpha and beta integrin subunits, revealed that oligodendrocytes express only one detectable integrin receptor complex (alpha OL beta OL). This complex is immunoprecipitated by a polyclonal anti-human beta 1 integrin subunit antibody. In contrast, astrocytes, the other major glial cell type in brain, express multiple integrins including alpha 1 beta 1, alpha 3 beta 1, and alpha 5 beta 1 complexes that are immunologically and electrophoretically indistinguishable from integrins expressed by rat fibroblasts. The beta subunit of the oligodendrocyte integrin (beta OL) and rat fibroblast beta 1 have different electrophoretic mobilities in SDS-PAGE. However, the two beta subunits appear to be highly related based on immunological cross-reactivity and one-dimensional peptide mapping. After removal of N-linked carbohydrate chains, beta OL and beta 1 comigrated in SDS-PAGE and peptide maps of the two deglycosylated subunits were identical, suggesting differential glycosylation of beta 1 and beta OL accounts entirely for their size differences. The oligodendrocyte alpha subunit, alpha OL, was not immunoprecipitated by antibodies against well characterized alpha chains which are known to associate with beta 1 (alpha 3, alpha 4, and alpha 5). However, an antibody to alpha 8, a more recently identified integrin subunit, did precipitate two integrin subunits with electrophoretic mobilities in SDS-PAGE identical to alpha OL and beta OL. Functional studies indicated that disruption of oligodendrocyte adhesion to a glial-derived matrix by an RGD-containing synthetic peptide resulted in a substantial decrease in the level of mRNAs for several myelin components including myelin basic protein (MBP), proteolipid protein (PLP), and cyclic nucleotide phosphodiesterase (CNP). These results suggest that integrin-mediated adhesion of oligodendrocytes may trigger signal(s) that induce the expression of myelin genes and thus influence oligodendrocyte differentiation.
Ka-Band, Multi-Gigabit-Per-Second Transceiver (2011)

A document discusses a multi-Gigabit-per-second, Ka-band transceiver with a software-defined modem (SDM) capable of digitally encoding/decoding data and compensating for linear and nonlinear distortions in the end-to-end system, including the traveling-wave tube amplifier (TWTA). This innovation can increase data rates of space-to-ground communication links, and has potential application to NASA s future spacebased Earth observation system. The SDM incorporates an extended version of the industry-standard DVB-S2, and LDPC rate 9/10 FEC codec. The SDM supports a suite of waveforms, including QPSK, 8-PSK, 16-APSK, 32- APSK, 64-APSK, and 128-QAM. The Ka-band and TWTA deliver an output power on the order of 200 W with efficiency greater than 60%, and a passband of at least 3 GHz. The modem and the TWTA together enable a data rate of 20 Gbps with a low bit error rate (BER). The payload data rates for spacecraft in NASA s integrated space communications network can be increased by an order of magnitude (>10 ) over current state-of-practice. This innovation enhances the data rate by using bandwidth-efficient modulation techniques, which transmit a higher number of bits per Hertz of bandwidth than the currently used quadrature phase shift keying (QPSK) waveforms.
Maritime Trade and Societal Transitions in the Western Indonesian Archipelago: Samudra-Pasai at the Dawn of the European Age (c. 1200-1500) (2017)

This study is the substantial update to a journal article published in 1981, focal on the first northeast Sumatra fourteenth- and fifteenthcentury Islamic Sultanate Samudra-Pasai port-of-trade. In doing so the study represents the significant transitions in Indian Ocean history that were substantially influenced by Michael Pearson’s scholarship. Samudra-Pasai was a notable eastern Indian Ocean fourteenth- and fifteenth-century Straits of Melaka international maritime stopover that competed against the west-central Malay Peninsula-based Melaka emporium for regional commercial prominence prior to Portuguese seizure of Melaka in 1511. Past histories are based on the several surviving contemporary maritime sojourner accounts, Chinese dynastic records, and the local sixteenth-century Hikayat Raja-Raja Pasai dynastic chronicle. Recent anthropological surveys of the Sumatra upstream pair with new archaeological recoveries, which include dated Arabic script inscribed dynastic tombstones, to mandate a re-evaluation of upstream downstream networking that was the basis of Samudra- Pasai’s over two-century sovereignty. This study moves beyond initially innovative 1970s conceptions of early Straits of Melaka upstreamdownstream networking in its incorporation of Michael Pearson’s adaptive characterizations of Indian Ocean port-of-trade coastline littorals, and introduces the importance of newly focal offshore communities as these are now prominent in the most recent Indian Ocean scholarship.
Long-term outcome of patients with depressed left ventricular function undergoing percutaneous transluminal coronary angioplasty. The NHLBI PTCA Registry. (1993)

PTCA is effective in selected patients with depressed left ventricular function. Initial outcome and risk-benefit ratio are excellent. Successful dilation of at least one vessel was achieved in 88% of patients with depressed left ventricular function and in 91% of patients with more normal left ventricular function. The former group, however, had a decreased incidence of successful dilation in all lesions in which dilation was attempted (76% versus 84%, p < 0.01). There was no significant difference in in-hospital complications between the two groups. During follow-up, patients with decreased left ventricular function had worse event-free survival, although 77% were alive without infarction or bypass grafting at 4 years.
First-in-Class Anticancer Nanoparticle Copper(II) Phosphorus Dendrimers as Pro-apoptotic Bax Activators (2018)

International audience
Immunohistochemical detection of terminal complement complex and S protein in normal and pre-eclamptic placentae (1990)

Terminal complement complex and S protein were searched for in term placentae obtained from 13 women with normal pregnancy and 15 patients with moderate or severe form of pre-eclampsia. Terminal complement complex was found to localize in the fibrinoid material of the decidua of the basal plate, in the stroma of the chorionic villi and in the vessel walls, as subendothelial deposits. S protein had a quite different distribution, being detected in the syncytiotrophoblast located both in the chorionic villi and in the decidua of the basal plate (DBP) and also on the endothelial cells of fetal stem vessels. Mild deposits of C3 were found in the decidua of the basal plate and also in the stroma and on the basal membranes of the villi. Reactivity for C9 neoantigen was also observed in the cytoplasm of some cells, which were recognized to be macrophages by the presence in their cytoplasm of acid phosphatase and by their reaction with a monoclonal antibody specific for macrophages. Differences in complement deposition in normal and pre-eclamptic placentae were essentially quantitative. Possible mechanisms of complement activation are discussed.
Vaccination Against COVID-19: Emerging Issues and Future Prospects (2021)

The most effective means of combating the COVID-19 pandemic s the formation of herd immunity, with the formation of an immune population to infection. Vaccination rates are continuously increasing. In early February 2021, WHO announced that the number of people vaccinated against the disease for the first time exceeded the number of infected. In early June 2021 the vaccinated number exceeded 2 billion which is more than 12 times the total number infected for the entire duration of the pandemic. The high rate of vaccination leads to the formulation of a number of questions concerning the effectiveness of vaccines currently used for mass immunization the level of herd immunity, necessary to stop the spread of the disease, the actual duration of the vaccination carried out, long-term prospects of the platforms, used in the creation of vaccines. The purpose of this paper is to substantiate reasoned answers to the questions posed.
Synthesis and Chemical Resolution of a Novel Class of Rigid 1-(1-Phenylcyclohexyl)-iperidine(PCP) Analogues (1990)

A novel class of conformationally rigidified phencyclidine (1-(1-phenylcyclohexyl)piperidine; PCP) analogues -4a-amino-1,4,4a,9a-tetrahydrofluorenes 1, 2, 5, 6 and 4a-amino-1,2,3,4,4a,9a-hexahydrofluorenes 3, 4, 7, 8 - has been prepared through a Diels-Alder approach and resolved by aid of (+)- and (-)-tartaric acid. One member of this series, the (4aR, 9aS)-4a-amino derivative 3, was found to exhibit a high affinity (IC50 = 19 nm) for the PCP recognition site in the brain, thus allowing a more rigorous assignment of the conformation of PCP relevant to binding at these sites.
<title>White LED</title> (1999)

Since several years light emitting diodes are in use to generate white light. Pixels with green, red and blue LED's are arranged to get any coordinate in the CIE--diagram with matched current for each diode. For instance Siemens Opto Semiconductor now OSRAM Opto Semiconductor offers multi chip LED's (LHGB T676) especially for the application above. A far better solution for producing white light represents luminescence conversion. The emitted light of blue diodes is used as a primary source for exciting organic or inorganic fluorescent. By conversion, `Stokes Shift', red, green, yellow and mixed colored light can be generated.
Perturbing the metal site in D-xylose isomerase. Effect of mutations of His-220 on enzyme stability. (1994)

The histidine residue at position 220 in the Streptomyces rubiginosus D-xylose isomerase is conserved in all D-xylose isomerases. The three-dimensional structure of D-xylose isomerase reveals that His-220 is part of the octahedral coordination sphere of M2, one of two metal ions (Mn2+) in the active site. This work describes the effects of replacing His-220 with Ser, Glu, Asn, and Lys. The consequences of these amino acid substitutions on enzyme activity, thermostability, and structure were analyzed by kinetic, denaturation, and crystallographic methods. The kcat values H220S, H220N, and H220E are only 0.3-0.5% of the wild-type values, and the Km for each of these mutant enzymes increased by 30-40-fold over the wild-type value. The mutant enzyme H220K did not exhibit any measurable activity. Thermal denaturation studies (Tm values) indicate that the H220S and H220N mutant enzymes are approximately 5-8 degrees C less stable than the wild-type enzyme, whereas H220E and H220K are 13-24 degrees C less stable than the wild-type enzyme. To analyze the molecular basis for this decreased thermostability, the crystal structures of the H220S, H220N, and H220E mutant enzymes complexed with Mn2+ have been determined at 1.95, 1.90, and 1.75 A, respectively. In the H220S structure, a water molecule effectively replaces the N epsilon-2 atom of the imidazole ring of His-220 and mediates the interaction between Mn2+ at the M2 site and Ser-220. A similar water-mediated interaction between the metal ion and Asn-220 is observed in H220N. No direct or water-mediated interactions between the carboxyl group of Glu-220 and the metal are observed in H220E. Whereas octahedral coordination is maintained for the metal at the M2 site in H220S and H220N, a pentahedral coordination with the metal at the M2 site is observed in H220E. Metal activation measurements support the observation that metal binding is perturbed and is responsible for thermal lability of His-220 mutants.
First Demonstration of 2.1 kW Output Power at 425 MHz Using 4H-SiC RF Power BJTs (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.