gebhart/patrepeval huggingface dataset:
In Vitro Intrinsic Clearance-Based Optimization ofN3-Phenylpyrazinones as Corticotropin-Releasing Factor-1 (CRF1) Receptor Antagonists (2009)

A series of pyrazinone-based heterocycles was identified as potent and orally active corticotropin-releasing factor-1 (CRF(1)) receptor antagonists. Selected compounds proved efficacious in an anxiety model in rats; however, pharmacokinetic properties were not optimal. In this article, we describe an in vitro intrinsic clearance-based approach to the optimization of pyrazinone-based CRF(1) receptor antagonists wherein sites of metabolism were identified by incubation with human liver microsomes. It was found that the rate of metabolism could be decreased by incorporation of appropriate substituents at the primary sites of metabolism. This led to the discovery of compound 12x, a highly potent (IC(50) = 1.0 nM) and selective CRF(1) receptor antagonist with good oral bioavailability (F = 52%) in rats and efficacy in the defensive withdrawal anxiety test in rats.
Inflammatory gut as a pathologic and therapeutic target in Parkinson’s disease (2022)

Parkinson's disease (PD) remains a significant unmet clinical need. Gut dysbiosis stands as a PD pathologic source and therapeutic target. Here, we assessed the role of the gut-brain axis in PD pathology and treatment. Adult transgenic (Tg) α-synuclein-overexpressing mice served as subjects and were randomly assigned to either transplantation of vehicle or human umbilical cord blood-derived stem cells and plasma. Behavioral and immunohistochemical assays evaluated the functional outcomes following transplantation. Tg mice displayed typical motor and gut motility deficits, elevated α-synuclein levels, and dopaminergic depletion, accompanied by gut dysbiosis characterized by upregulation of microbiota and cytokines associated with inflammation in the gut and the brain. In contrast, transplanted Tg mice displayed amelioration of motor deficits, improved sparing of nigral dopaminergic neurons, and downregulation of α-synuclein and inflammatory-relevant microbiota and cytokines in both gut and brain. Parallel in vitro studies revealed that cultured dopaminergic SH-SY5Y cells exposed to homogenates of Tg mouse-derived dysbiotic gut exhibited significantly reduced cell viability and elevated inflammatory signals compared to wild-type mouse-derived gut homogenates. Moreover, treatment with human umbilical cord blood-derived stem cells and plasma improved cell viability and decreased inflammation in dysbiotic gut-exposed SH-SY5Y cells. Intravenous transplantation of human umbilical cord blood-derived stem/progenitor cells and plasma reduced inflammatory microbiota and cytokine, and dampened α-synuclein overload in the gut and the brain of adult α-synuclein-overexpressing Tg mice. Our findings advance the gut-brain axis as a key pathological origin, as well as a robust therapeutic target for PD.
Controlling the carrier recombination zone for improved color stability in a two-dopant fluorophore/phosphor white organic light-emitting diode (2009)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Unnat S. Bhansali, Huiping Jia, M. A. Quevedo Lopez, Bruce E. Gnade, Wei-Hsuan Chen, Mohammad A. Omary; Controlling the carrier recombination zone for improved color stability in a two-dopant fluorophore/phosphor white organic light-emitting diode. Appl. Phys. Lett. 18 May 2009; 94 (20): 203501. https://doi.org/10.1063/1.3089867 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioApplied Physics Letters Search Advanced Search |Citation Search
Scintillation Response of Nd-Doped LaMgAl11O19 Single Crystals Emitting NIR Photons for High-Dose Monitoring (2022)

The Nd-doped LaMgAl<sub>11</sub>O<sub>19</sub> single crystals were synthesized by the floating zone method, and the photoluminescence and scintillation properties were evaluated. Under X-ray irradiation, several sharp emission peaks due to the 4f-4f transitions of Nd<sup>3+</sup> were observed at 900, 1060, and 1340 nm in the near-infrared range, and the decay curves show the typical decay time for Nd<sup>3+</sup>. The samples show good afterglow properties comparable with practical X-ray scintillators. The 1% and 3% Nd-doped LaMgAl<sub>11</sub>O<sub>19</sub> samples show a good linearity in the dynamic range from 6-60,000 mGy/h.
The L1 major capsid protein of HPV16 differentially modulates APC trafficking according to the vaccination or natural infection context (2010)

Human papillomavirus (HPV) infection, particularly type 16, is causally associated with cancer of the uterine cervix. The progression of cervical lesions suggests that viral antigens are not adequately presented to the immune system. The aim of this study was to determine whether HPV16 viral particles can influence the trafficking of human DC/Langerhans cells (LC), either by direct interactions with DC or following incubation with human normal keratinocytes that are in close contact with LC in the squamous epithelium. We first demonstrated that HPV16 L1 major capsid protein, when self-assembled into virus-like particles (VLP), is able to induce in DC an over-expression of CXC receptor 4 (CXCR4) via the activation of the NF-κB signaling pathway and to enhance DC motility in the presence of CXCL12, suggesting an ability to migrate towards lymph nodes. We also showed that conditioned media of HPV16 VLP-treated keratinocytes induce a lower LC migration than those from untreated keratinocytes and that prostaglandin E2 (PGE(2)), detected in HPV16 VLP-treated keratinocyte supernatants, may reduce LC recruitment into the squamous epithelium. Taken together, our data demonstrate that HPV16 VLP may differentially regulate the immune protective response according to their target cells.
<title>Excite-probe two-color Z-scan</title> (1992)

Using an excite-i,robe two-co1or Zscan technique, we investigate the dynamics of optical nonlinearites in semiconductors with picosecond pulses at 1.06 and 0.532 pm. We use the technique to obtain a direct timeresolved measurement of the nondegenerate nonlinear refraction in polycrystalline ZnSe and show how it can resolve the bound electronic and free carrier components.
High Endurance Self-Heating OTS-PCM Pillar Cell for 3D Stackable Memory (2018)

For the first time published, high endurance OTS (ovonic threshold switch, here, TeAsGeSiSe-based) is integrated with PCM (here, doped Ge2Sb2Te5) to form a 3D stackable pillar type device. With the help of an etch buffer layer and a damage-free pillar RIE process, we achieved 100% array yield without OTS/PCM composition modification. Anneal tests show this one-selector/one-resistor (1S1R) pillar device is BEOL-compatible.We report excellent electrical performance by 1S1R OTS-PCM device; selector provides the fast turn on/off speed which enables 10ns fast RESET speed, program endurance is 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">9</sup> cycles, and read endurance is higher than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sup> cycles.
Mutations in Col4a1 Cause Perinatal Cerebral Hemorrhage and Porencephaly (2005)

Porencephaly is a rare neurological disease, typically manifest in infants, which is characterized by the existence of degenerative cavities in the brain. To investigate the molecular pathogenesis of porencephaly, we studied a mouse mutant that develops porencephaly secondary to focal disruptions of vascular basement membranes. Half of the mutant mice died with cerebral hemorrhage within a day of birth, and approximately 18% of survivors had porencephaly. We show that vascular defects are caused by a semidominant mutation in the procollagen type IV alpha 1 gene (Col4a1) in mice, which inhibits the secretion of mutant and normal type IV collagen. We also show that COL4A1 mutations segregate with porencephaly in human families. Because not all mutant mice develop porencephaly, we propose that Col4a1 mutations conspire with environmental trauma in causing the disease.
Extraction error modeling and automated model debugging in high-performance custom designs (2006)

In the design cycle of high-performance integrated circuits, it is common that certain components are designed directly at the transistor level. This level of design representation may not be appropriate for test generation tools that usually require a model expressed at the gate level. Logic extraction is a key step in test model generation to produce a gate-level netlist from the transistor-level representation. This is a semi-automated process which is error-prone. Once a test model is found to be erroneous, manual debugging is required, which is a resource-intensive and time-consuming process. This paper presents an in-depth analysis of typical sets of extraction errors found in the test model representations of the pipelines in high-performance designs today. It also develops an automated debugging solution for single extraction errors for pipelines with no state equivalence information. A suite of experiments on circuits with similar architecture to that found in the industry confirms the fitness and practicality of the solution.
The Depth-to-Width Interplay in Self-Attention (2020)

Self-attention architectures, which are rapidly pushing the frontier in natural language processing, demonstrate a surprising depth-inefficient behavior: previous works indicate that increasing the internal representation (network width) is just as useful as increasing the number of self-attention layers (network depth). We theoretically predict a width-dependent transition between depth-efficiency and depth-inefficiency in self-attention. We conduct systematic empirical ablations on networks of depths 6 to 48 that clearly reveal the theoretically predicted behaviors, and provide explicit quantitative suggestions regarding the optimal depth-to-width allocation for a given self-attention network size. The race towards beyond 1-Trillion parameter language models renders informed guidelines for increasing self-attention depth and width in tandem an essential ingredient. Our guidelines elucidate the depth-to-width trade-off in self-attention networks of sizes up to the scale of GPT3 (which we project to be too deep for its size), and beyond, marking an unprecedented width of 30K as optimal for a 1-Trillion parameter network.
Virtual Intensive Care Unit (ICU): Real-Time Simulation Environment Applying Hybrid Approach Using Dynamic Bayesian Networks and ODEs (2009)

Combining deterministic (e.g. differential equations) and probabilistic (Bayesian Networks) approaches to model physiological processes in a real-time software environment leads to a novel model for simulation of human patient physiology especially relevant for intensive care units (ICU). Using dedicated HW/SW interfaces simulated patient signals are measurable with standard monitoring systems. Therefore, this system, based on realistic simulations, is very well suited for teaching and education. Additionally, the environment is usable for inferring patient-specific model structures and parameters. We introduce a hierarchical modeling approach, which allows building complex models based on aggregation of simple sub models. The simulation is controlled to run in real-time with typical sampling times of 1-10 ms (depending on model complexity) on a standard PC (Pentium 2.66 GHz CPU).
High confinement suspended micro-ring resonators in silicon-on-insulator (2006)

We demonstrate suspended micrometer-scale ring resonators with quality factors exceeding 15,000. The high quality factor is achieved by using a suspension method where the disturbance of the optical mode due to the support arms is minimized. We show an insertion loss of less than .02dB per suspension bridge.
Two competing queues with linear costs: The µc-rule is often optimal (1983)

A discrete-time model is presented for a system of two queues that compete for the service attention of a single server with infinite buffer capacity. The arrivals are modelled by an i.i.d, random sequence of a general type while the service completions are generated by independent Bernou lli streams, and the allocation of service attention is governed by feedback policies which are based on past decisions and buffer content histories. The cost of operation per unit time is a linear function of the queue sizes. Under the model assumptions, a fixed prioritization scheme, known as the µc-rule, is shown, to be optimal when the expected long-run average criterion and the expected discounted criterion, over both finite and infinite horizons, are used. The analysis is based on the Dynamic Programming methodology for Markov decision processes and takes advantage of the sample path properties of the adopted state-space model.
Biological uptake vs. coprecipitation of soluble reactive phosphorus by ‘P-enriched’ and ‘P-deficient’Najas guadalupensisin hard and soft waters (2002)

(2002). Biological uptake vs. coprecipitation of soluble reactive phosphorus by ‘P-enriched’ and ‘P-deficient’ Najas guadalupensis in hard and soft waters. SIL Proceedings, 1922-2010: Vol. 28, No. 4, pp. 1865-1870.
Fair Energy Allocation in Risk-aware Energy Communities (2023)

This work introduces a decentralized mechanism for the fair and efficient allocation of limited renewable energy sources among consumers in an energy community. In the proposed non-cooperative game, the self-interested community members independently decide whether to compete or not for access to RESs during peak hours and shift their loads analogously. In the peak hours, a proportional allocation (PA) policy is used to allocate the limited RESs among the competitors. The existence of a Nash equilibrium (NE) or dominant strategies in this non-cooperative game is shown, and closed-form expressions of the renewable energy demand and social cost are derived. Moreover, a decentralized algorithm for choosing consumers' strategies that lie on NE states is designed. The work shows that the risk attitude of the consumers can have a significant impact on the deviation of the induced social cost from the optimal. Besides, the proposed decentralized mechanism with the PA policy is shown to attain a much lower social cost than one using the naive equal sharing policy.
The Influence Of Combine Preparation Training Duration On NFL Combine Or Pro Day Performance (2019)

For collegiate football players, an outstanding performance at the NFL scouting combine or an athlete’s college pro-day may increase the likelihood of being drafted or signed to an NFL team. In recent years, it has become common for players to decline playing in bowl games to allow for additional preparation for combine and pro-day performance. PURPOSE: To determine if the duration of combine preparation training influences NFL Combine or Pro Day performance. METHODS: 23 college football players (22.6±0.51 y, 108.8±18.2 kg 1.88±0.07 m) completed a preparation training program leading up to the 2018 NFL combine and college pro-days. Prior to training, all players were assessed in the 40yd dash, 225 bench press test, 3-cone drill, pro-agility test, broad jump and vertical jump. Post-training values were obtained from the players combine or pro-day performances and athlete data were then allocated to two groups: (1) athletes who completed 9-10 weeks of training (n=11) and (2) athletes who completed 6-8 weeks of the same training program (n=12). Combine training consisted of 4 resistance training sessions per week with position and test specific training occurring 6 days a week for the duration of the program. An analysis of variance with repeated measures was used to assess differences in training outcomes for each variable. RESULTS: Significant (p < 0.05) main effects for time were observed for improvements in 40-yard dash times (p = 0.046), 3-cone drill time (p = 0.002), along with 225 bench press repetitions, vertical jump height, broad jump distance, and pro-agility drill time (p < 0.001). There were no significant group by time interactions for any of the physical performance tests. Out of the 23 participants, 3 players were drafted and were on active rosters for the 2018 NFL season, one participant was drafted and signed a practice squad contract, while 5 other participants signed undrafted free agent contracts with various NFL teams. CONCLUSION: It appears that length of combine preparation did not produce significant differences in pro day performance between the two groups. Therefore, NFL hopefuls can improve their combine performance even with a short duration combine training program.
Characterization of selective and potent PI3Kδ inhibitor (PI3KD-IN-015) for B-Cell malignances (2016)

PI3Kδ is predominately expressed in leukocytes and has been found overexpressed in B-cell related malignances such as CLL and AML. We have discovered a highly selective ATP competitive PI3Kd inhibitor PI3KD-IN-015, which exhibits a high selectivity among other PI3K isoforms in both biochemical assays and cellular assay, meanwhile did not inhibit most of other protein kinases in the kinome. PI3KD-IN-015 demonstrates moderately anti-proliferation efficacies against a variety of B-cell related cancer cell lines through down-regulate the PI3K signaling significantly. It induced both apoptosis and autophagy in B-cell malignant cell lines. In addition, combination of autophagy inhibitor Bafilomycin could potentiate the moderate anti-proliferation effect of PI3KD-IN-015. PI3KD-IN-015 shows anti-proliferation efficacy against CLL and AML patient primary cells. Collectively, these results indicate that PI3KD-IN-015 may be useful drug candidate for further development of anti-B-cell related malignances therapies.
Modeling Balanced Armature Transducers at High Amplitudes (2020)

International audience
Diphenylpyridylethanamine (DPPE) Derivatives as Cholesteryl Ester Transfer Protein (CETP) Inhibitors (2012)

A series of diphenylpyridylethanamine (DPPE) derivatives was identified exhibiting potent CETP inhibition. Replacing the labile ester functionality in the initial lead 7 generated a series of amides and ureas. Further optimization of the DPPE series for potency resulted in the discovery of cyclopentylurea 15d, which demonstrated a reduction in cholesterol ester transfer activity (48% of predose level) in hCETP/apoB-100 dual transgenic mice. The PK profile of 15d was suboptimal, and further optimization of the N-terminus resulted in the discovery of amide 20 with an improved PK profile and robust efficacy in transgenic hCETP/apoB-100 mice and in hamsters. Compound 20 demonstrated no significant changes in either mean arterial blood pressure or heart rate in telemeterized rats despite sustained high exposures.
Natural-abundance two-dimensional solid-state silicon-29 NMR investigations of three-dimensional lattice connectivities in zeolite structures (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNatural-abundance two-dimensional solid-state silicon-29 NMR investigations of three-dimensional lattice connectivities in zeolite structuresColin A. Fyfe, Y. Feng, H. Gies, H. Grondey, and G. T. KokotailoCite this: J. Am. Chem. Soc. 1990, 112, 9, 3264–3270Publication Date (Print):April 1, 1990Publication History Published online1 May 2002Published inissue 1 April 1990https://doi.org/10.1021/ja00165a002RIGHTS & PERMISSIONSArticle Views330Altmetric-Citations93LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (814 KB) Get e-Alertsclose Get e-Alerts
Alignment Effects for Nematic Liquid Crystal Using a-C:H Thin Film as Working Gas at Bias Condition (2004)

We investigated the nematic liquid crystal (NLC) aligning capabilities using the new alignment material of a-C:H thin film as working gas at 30 W rf bias condition. A high pretilt angle by ion beam(IB) exposure on the a-C:H thin film surface was measured. A good LC alignment by the IB alignment method on the a-C:H thin film surface was observed at annealing temperature of 250°C, and the alignment defect was observed above annealing temperature of 300°C.
Electrodeposited Cobalt–Copper mixed oxides for supercapacitor electrodes and investigation of the Co/Cu ratio on the electrochemical performance (2023)

Abstract In this study, different Cobalt–Copper mixed oxides compositions for supercapacitor electrodes have been prepared, by means of electrodeposition and thermal annealing. The chemical–physical and electrochemical characterization of electrodes, as well as the effect of different Co/Cu in the ratios on the crystal lattice, electrode morphologies, and electrochemical performance of the electrodes, were investigated using X-ray diffraction (XRD), scanning electron microscopic (SEM) and cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and galvanostatic charge/discharge (GCD) tests. The results indicated that the electrode prepared from 0.06 M CoSO 4 ·7H 2 O + 0.04 M CuSO 4 ·5H 2 O solution (CC4) had a better electrochemical performance. The initial capacity of the CC4 electrode was 28.3 mAh/g at a scan rate of 5 mV/s with a coulombic efficiency of 94%. CC4 electrode featured capacity retention of 79.2% at a constant current density of 1 A/g after 5000 cycles.
Building confidence in system behavior (2013)

If the use of Ada (or SPARK or some other tool) increases our confidence in the behavior of high integrity software systems, why does it do so? What do we mean by confidence, and what is a justified basis for asserting some level of confidence? In this talk, I'll address some recent research on the potential value of thinking about confidence in terms of eliminative induction, assurance cases, and confidence maps.
Detaecting large-area optical fields using geometric fiber constructs (2006)

We demonstrate that two- and three-dimensional geometric constructs of flexible and lightweight photosensitive fibers may be designed to obtain the amplitude and phase of an optical field on unprecedented length scales.