gebhart/patrepeval huggingface dataset:
Policy-based automated provisioning (2004)

The term “policy-based computing” refers to a software paradigm that incorporates a set of decision-making technologies into its management components in order to simplify and automate the administration of computer systems. A significant part of this simplification is achieved by allowing administrators and operators to specify management operations in terms of objectives or goals, rather than detailed instructions that need to be executed. A higher level of abstraction is thus supported, while permitting dynamic adjustment of the behavior of the running system without changing its implementation. This paper focuses on the application of the policy-based software paradigm to the automated provisioning architecture described elsewhere in this issue. We show how the use of policies can enhance utility computing services by making them more customizable and more responsive to business objectives.
Finite Element Analysis of Spinal Cord Injury in the Rat (2008)

A three-dimensional (3D) finite element model (FEM) that simulates the Impactor weight-drop experimental model of traumatic spinal cord injury (SCI) was developed. The model consists of the rat spinal cord, with distinct element sets for the gray and white matter, the cerebrospinal fluid (CSF), the dura mater, a rigid rat spinal column, and a rigid impactor. Loading conditions were taken from the average impact velocities determined from previous parallel weight-drop experiments employing a 2.5-mm-diameter, 10-g rod dropped from either 12.5 or 25 mm. The mechanical properties were calibrated by comparing the predicted displacement of the spinal cord at the impact site to that measured experimentally. Parametric studies were performed to determine the sensitivity of the model to the relevant material properties, loading conditions, and essential boundary conditions, and it was determined that the shear modulus had the greatest influence on spinal cord displacement. Additional simulations were performed where gray and white matter were prescribed different material properties. These simulations generated similar drop trajectories to the homogeneous model, but the stress and strain distributions better matched patterns of acute albumin extravasation across the blood-spinal cord barrier following weight-drop SCI, as judged by a logit analysis. A final simulation was performed where the impact site was shifted laterally by 0.35 mm. The off-center impact had little effect on the rod trajectory, but caused marked shifts in the location of stress and strain contours. Different combinations of parameter values could reproduce the impactor trajectory, which suggests that another experimental measure of the tissue response is required for validation. The FEM can be a valuable tool for understanding the injury biomechanics associated with experimental SCI to identify areas for improvement in animal models and future research to identify thresholds for injury.
Scalable 2D arrays of noise sources for stochasticretina (1997)

The design of scalable 2D arrays of Gaussian white noise sources is addressed. Two original circuits based on cellular automata are described, and the choice of the cellular automaton transition function is discussed.
Polarized Emission of Individual Self-Assembled Oligo(p-phenylenevinylene)-Based Nanofibers on a Solid Support (2005)

We have prepared 5 nm diameter, micrometer long tetra(p-phenylenevinylene) (OPV)-based nanofibers on a graphite surface. The fluorescence emission of an individual fiber shows a profound polarization over its entire length that directly corresponds to its orientation on the substrate. Quantitative analysis of the fluorescence polarization, including the depolarizing effect of the underlying graphite, evidences the high degree of organization within chiral fibers with the OPV molecules perpendicular to the fiber axis. The control of the internal order within self-assembled fibers, and the ability to measure it, is a crucial step to obtain uniform organic fibers that can be applied in nanosized electronics at room temperature.
Towards 5G-ready Security Metrics (2021)

The fifth-generation (5G) mobile telecom network has been garnering interest in both academia and industry, with better flexibility and higher performance compared to previous generations. Along with functionality improvements, new attack vectors also made way. Network operators and regulatory organizations wish to have a more precise idea about the security posture of 5G environments. Meanwhile, various security metrics for IT environments have been around and attracted the community’s attention. However, 5G-specific factors are less taken into consideration.This paper considers such 5G-specific factors to identify potential gaps if existing security metrics are to be applied to the 5G environments. In light of the layered nature and multi-ownership, the paper proposes a new approach to the modular computation of security metrics based on cross-layer projection as a means of information sharing between layers. Finally, the proposed approach is evaluated through simulation.
Ultrafast all-optical switching at 1.55 /spl mu/m using an organic multilayer device (2004)

Ultrafast all-optical switching is carried out at optical communication wavelength by adopting a layered structure of spin-coated organic films. Signal-noise ratio more than 25 dB and a sub-picosecond response time are observed at 1.55 /spl mu/m.
Pregnenolone sulphate and Zn2+ inhibit recombinant rat GABAA receptor through different channel property (2006)

Pregnenolone sulphate was a gamma2-subunit independent inhibitor in the GABA(A) receptor, whereas the Zn(2+) antagonism was profoundly influenced by the gamma2-subunit. It is likely that the 2' residue closest to the N-terminus of the protein at M(2) helix on both alpha1 and beta2 subunit are critical to the inhibitory actions of PS and the function of Cl(-) channels. These results are consistent with the hypothesis that PS behaves as a Cl(-) channel blocker that does not share with Zn(2+), the coincident channel property in the GABA(A) receptors.
Piezoelectric Bulk Mode Disk Resonator Post-Processed for Enhanced Quality Factor Performance (2016)

This paper presents a bulk-mode disk resonator utilizing a transverse piezoelectric actuation technique to drive the single crystalline silicon disk structure in its wine-glass bulk mode of resonance. The device is fabricated by post-processing dies from a commercial microelectromechanical systems process and combines high quality factor and relatively low motional resistance. Post-process fabrication steps are used to reduce the width of the anchor beam supports, and consequently reduce the anchor losses. This results in a factor of 3 increase in the quality factor. Post-processed resonators were measured to have resonance frequencies of 23 MHz and quality factors of 13000 in atmospheric pressure, increasing to 31000 in 1 mTorr vacuum. The devices also demonstrate motional resistances of 21 kQ in atmospheric pressure, reducing to 8.8 kQ in 1 mTorr vacuum without requiring any dc voltage for operation.
Doppler velocity detection limitations in spectrometer-based versus swept-source optical coherence tomography (2011)

Recent advances in Doppler techniques have enabled high sensitivity imaging of biological flow to measure blood velocities and vascular perfusion. Here we compare spectrometer-based and wavelength-swept Doppler OCT implementations theoretically and experimentally, characterizing the lower and upper observable velocity limits in each configuration. We specifically characterize the washout limit for Doppler OCT, the velocity at which signal degradation results in loss of flow information, which is valid for both quantitative and qualitative flow imaging techniques. We also clearly differentiate the washout effect from the separate phenomenon of phase wrapping. We demonstrate that the maximum detectable Doppler velocity is determined by the fringe washout limit and not phase wrapping. Both theory and experimental results from phantom flow data and retinal blood flow data demonstrate the superiority of the swept-source technique for imaging vessels with high flow rates.
Abstract 2575: Differentiation of NUT midline carcinoma by epigenomic reprogramming (2011)

Abstract NUT midline carcinoma (NMC) is a lethal tumor defined by the presence of BRD-NUT fusion proteins that act by arresting differentiation. Here, we explore the mechanisms underlying the ability of BRD4-NUT to prevent squamous differentiation. We find that overexpression of the twin bromodomains of BRD4 or a portion of NUT that binds the histone acetyltransferase (HAT) p300 induces NMC cells to differentiate, suggesting a model in which BRD4-NUT sequesters HATs in areas of acetylated chromatin. Consistent with this idea, knockdown of BRD4-NUT caused global increases in histone acetylation, whereas enforced expression of BRD4-NUT had the opposite effect. Sequestration of HATs appears to occur in nuclear BRD4-NUT foci, which correspond to specific genomic regions that are rich in acetylated histones but transcriptionally inactive. Of therapeutic interest, treatment of NMC cells with histone deacetylase inhibitors (HDACi) dispersed nuclear foci, restored histone acetylation, induced NMC cells to differentiate in vitro, and had anti-tumor effects in NMC xenograft models. The data suggest that this rational therapeutic approach merits further evaluation in patients with NMC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2575. doi:10.1158/1538-7445.AM2011-2575
Transmission System Modular Design of Production Type CMM (2015)

Based on the program modular design methodology, modulate the transmission system with CAD program design concept, the content and relationship of each module were defined. Based on the function modular design methodology and independence principle of module function structure, each specific module of the transmission system was defined. Based on this process, the conclusion showed that the Pearl Model CMM should choose two-stage non-cantilever cog belt transmission system, and the two-gears should be in opposite position. The transmission system design feature Pearl Model CMM was clarified, to show the modular design concept effectiveness and practicability.
Outcome of acute lymphoblastic leukemia in children with down syndrome—Polish pediatric leukemia and lymphoma study group report (2017)

Children with Down syndrome (DS) have a 20-fold increased risk of developing leukemia compared with the general population. The aim of the study was to analyze the outcome of patients diagnosed with Down syndrome and acute lymphoblastic leukemia (ALL) in Poland between the years 2003 and 2010. A total of 1848 children were diagnosed with ALL (810 females and 1038 males). Of those, 41 (2.2%) had DS. The children were classified into three risk groups: a standard-risk group-14 patients, an intermediate-risk group-24, a high-risk group-3. All patients were treated according to ALLIC 2002 protocol. The median observation time of all patients was 6.1 years, and in patients with DS 5.3 years. Five-year overall survival (OS) was the same in all patients (86% vs 86%, long-rank test, p = .9). The relapse-free survival (RFS) was calculated as 73% in patients with DS and 81% in patients without DS during a median observation time (long-rank test, p = .3). No statistically significant differences were found in the incidence of nonrelapse mortality between those two groups of patients (p = .72). The study was based on children with ALL and Down syndrome who were treated with an identical therapy schedule as ALL patients without DS, according to risk group. This fact can increase the value of the presented results.
ChemInform Abstract: Cycloaddition of Keteniminium with Terminal Alkynes Toward Cyclobuteniminium and Their Use in Diels—Alder Reactions. (2015)

Abstract Cyclobutinium salts react with dienes to form bicyclic compounds with high regio‐ and stereoselectivities.
Poly(Ethylene Glycol)-Supported Proline: A Versatile Catalyst for the Enantioselective Aldol and Iminoaldol Reactions (2002)

(2S,4R)-4-Hydroxyproline has been anchored to the monomethyl ether of poly(ethylene glycol), MW 5000, by means of a succinate spacer to afford a soluble, polymer-supported catalyst (PEG-Pro) for enantioselective aldol and iminoaldol condensation reactions. This organic catalyst can be considered as a minimalistic version of a type I aldolase enzyme, with the polymer chain replacing the enzyme's peptide backbone, and the proline residue acting as the enzyme's active site. In the presence of PEG-Pro (0.25–0.35 mol equiv.), acetone reacted with enolizable and non-enolizable aldehydes and imines to afford β-ketols and β-aminoketones in good yield and high enantiomeric excess (ee), comparable to those obtained using non-supported proline derivatives as the catalysts. Extension of the PEG-Pro-promoted condensation to hydroxyacetone as the aldol donor opened an access to synthetically relevant anti-α,β-dihydroxyketones and syn-α-hydroxy-β-aminoketones, that were obtained in moderate to good yields, and good to high diastereo- and enantioselectivity. Exploiting its solubility properties, the PEG-Pro catalyst was easily recovered and recycled to promote all of the above-mentioned reactions, that occurred in slowly diminishing yields but virtually unchanged ee's.
Mechanisms of Acquired Thymic Tolerance In Vivo: Intrathymic Injection of Antigen Induces Apoptosis of Thymocytes and Peripheral T Cell Anergy (1998)

Intrathymic injection of Ag induces Ag-specific tolerance in several clinically relevant experimental autoimmune and transplantation models. However, the exact mechanisms of acquired thymic tolerance in vivo remain unclear. We investigated the mechanisms of acquired thymic tolerance in mice that are transgenic for the TCR specific for peptide 323-339 of OVA. Intrathymic injection of OVA leads to apoptosis of thymocytes starting as early as 3 h after injection and persisting up to 7 days. Double positive thymocytes undergo apoptosis earlier than single positive thymocytes, and significantly higher percentages of double positive thymocytes ultimately die as compared with single positive cells. Apoptotic cells show decreased surface expression of CD4. In the periphery, T cells from intrathymically injected animals had suppressed proliferation and IL-2 production to OVA compared with T cells from control Ag-injected mice. We conclude that intrathymic injection of Ag induces apoptosis of immature thymocytes and a subpopulation of mature thymocytes and induces prolonged anergy in peripheral T cells in vivo. Understanding the mechanisms of acquired thymic tolerance may lead to development of novel clinical strategies to prevent autoimmune disease and transplant rejection.
Evaluation of the Specific Interactions between Glycodendrimeric Porphyrins, Free or Incorporated into Liposomes, and Concanavaline A by Fluorescence Spectroscopy, Surface Pressure, and QCM-D Measurements (2010)

In photodynamic therapy, the specificity of a photosensitizer and its penetration into tumor cells are crucial. We have analyzed the ability of newly synthesized meso-(tetraphenyl)porphyrins to be recognized by a model of mannose-specific proteins overexpressed at the surface of retinoblastoma cells. The specific interaction of porphyrin with Con A was studied by surface pressure measurements, fluorescence spectroscopy, dynamic light scattering, and QCM-D. The extent of porphyrins binding to Con A was highly dependent upon their chemical structure. Glycodendrimeric porphyrins showed the higher binding constant to Con A. The length of the spacer separating the sugar from the tetrapyrrolic ring appeared to be crucial in controlling the interaction of the compounds with the lectin in solution or immobilized onto a solid substrate. The methodology used proved to be efficient for the selection of potentially active compounds. The glycodendrimeric porphyrins, especially the derivative having the longer spacer, interacted more significantly with the lectin than the compound devoid of any sugar.
Assessment of pulmonary veins after atrio-pericardial anastomosis by cardiovascular magnetic resonance (2011)

Echocardiography incompletely imaged or underestimated the severity of obstruction in patients compared with CMR. Pulmonary vein stenosis remains a sizable complication after repair, even using the APA.
Large-area, uniform white light LED source on a flexible substrate (2015)

This study demonstrates the flexible white LED structure with high lumen efficiency and uniform optical performance for neutral white and warm white CCT. Flip-chip LEDs were attached on a polyimide substrate with copper strips as electrical and thermal conduction paths. Yellow phosphors are mixed with polydimenthysiloxane (PDMS) to provide mechanical support and flexibility. The light efficiency of this device can reach 120 lm/W and 85% of light output uniformity of the emission area can be achieved. Moreover, the optical simulation is employed to evaluate various designs of this flexible film in order to obtain uniform output. Both the pitch between the individual devices and the thickness of the phosphor film are calculated for optimization purpose. This flexible white LED with high lumen efficiency and good reliability is suitable for the large area fixture in the general lighting applications.
Synthesis of Febrifugine Derivatives and a Solution to the Puzzle of the Structural Determination of Febrifugine. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
The Natural History of Observed Enhancing Renal Masses: Meta-Analysis and Review of the World Literature (2006)

The majority of small enhancing renal masses grow at a slow rate when observed. Although metastatic and cancer specific death are low, serial radiographic data alone are insufficient to predict the true natural history of these lesions. Therefore, physicians and patients assume a calculated risk when following these tumors. Basic biological data are needed to assess the natural history of untreated renal masses.
Fluoropolymer Synthesis in Carbon Dioxide-Expanded Liquids: A Practical Approach to Avoid the Use of Perfluorooctanoic Acid (2009)

Successful polymerization of tetrafluoroethylene (TFE) in CO2-expanded liquids to synthesize polytetrafluoroethylene (PTFE) was demonstrated using both hydrocarbon and hydrofluorocarbon solvents. Yields were satisfactory and samples with thermal properties comparable to commercial polymer were produced. The chain transfer reaction that resulted from the use of hydrogen-containing solvents was not as severe as expected. Acetic acid was identified as a particularly promising expandable solvent. Use of this solvent lowers the pressure required for polymerization of TFE, and acetic acid is less environmentally detrimental than halogenated solvents. A wide range of solvent ratios and pressures were found to be suitable for TFE polymerization in CO2-expanded acetic acid. Colloidal PTFE samples were obtained in an emulsion-like polymerization run in CO2-expanded acetic acid. A commercially-available, conventional hydrocarbon surfactant was used in this research; the process did not require fluorinated surfactants such as perfluorooctanoic acid (PFOA) or other the specially designed surfactants for CO2 systems.
I viaggi della Memoria. Percorsi della Memoria europea per la pace (2019)

introduzione all'intervento del convegno oggetto del volume. In particolare il percorso di costruzione di processi di memoria a livello didattico educativo attraverso i viaggi nei luoghi della memoria
A Bicontinuous Double Gyroid Hybrid Solar Cell (2008)

We report the first successful application of an ordered bicontinuous gyroid semiconducting network in a hybrid bulk heterojunction solar cell. The freestanding gyroid network is fabricated by electrochemical deposition into the 10 nm wide voided channels of a self-assembled, selectively degradable block copolymer film. The highly ordered pore structure is ideal for uniform infiltration of an organic hole transporting material, and solid-state dye-sensitized solar cells only 400 nm thick exhibit up to 1.7% power conversion efficiency. This patterning technique can be readily extended to other promising heterojunction systems and is a major step toward realizing the full potential of self-assembly in the next generation of device technologies.
Flexible Needle Steering System for Percutaneous Access to Deep Zones of the Brain (2006)

The authors describe a minimally invasive flexible needle-steering system to access deep areas of the brain. The design exploits the inherent bending of a beveled-tip needle when passing through tissue. Precise control of the rotation of the needle allows for an unlimited variety of trajectories. Potential advantages to this system include the possibility of catheter-based therapy delivery within the brain with minimal trauma to surrounding structures, and the ability to navigate around critical cerebral structures to reach deep zones within the brainstem, thalamus or other subcortical regions.
A Deep-Subthreshold Variation-Aware 0.2-V Open-Loop VCO-Based ADC (2021)

This article demonstrates the potential of deep-subthreshold mixed-signal circuits in delivering medium-to-high performance to supply-constrained, energy-harvesting Internet of Things (IoT) sensing applications. This effort encapsulates the design and implementation of an ultra-low-voltage (ULV) 0.2-V open-loop VCO-based analog-to-digital converter (ADC). A replica VCO facilitates variation-aware VCO analog linearization. Analog phase-domain signal processing (APSP) techniques for beat-frequency extraction, phase-interpolation, and phase-folding relax constraints on both voltage-to-frequency analog circuitry and frequency-to-digital synchronous digital hardware. High-speed multi-phase frequency-to-digital converters (FDCs) and multi-rate digital back-end enable a sampling speed of 35 MS/s. The ADC prototype is implemented in 28-nm CMOS and achieves a peak SNDR of 64.4/59.9 dB, equivalent to an ENOB of 10.4/9.7 over 80-/160-kHz bandwidth (BW). The ADC core occupies an active area of 0.12 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and consumes 15.9 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mu \text {W}$ </tex-math></inline-formula> , resulting in a Walden and Schreier FoM of, respectively, 73.3/61.5 fJ/c-s and 161.4/159.9 dB at the corresponding BW configurations. Measurements across multiple ICs and supply voltages consolidate the value of variation-aware deep-subthreshold open-loop ADCs.
High-Extinction Linear Cascaded-Microcavity Filters (2012)

We design cascaded waveguide microcavities. Using realistic design parameters based on previously demonstrated single-stage devices, we model filters with &gt;60dB extinction, 100GHz FSR and 1GHz bandwidth. Initial experimental results are presented.
4.7 GB Phase-Change Optical Disk for an Authoring System of Digital Versatile Disc (1998)

A phase-change optical disk that has an optical phase-shift signal reproducing structure and the same physical specifications as the 4.7 GB read-only digital versatile disc (DVD) was developed. A minimum jitter of 9% and a wide tilt tolerance for the jitter were obtained under DVD reproducing conditions of λ=650 nm and N A =0.60. This new medium can be used as an inspection tool for DVD authoring. It was also confirmed that this optical disk had a potential for use as a rewritable 4.7 GB DVD medium that has compatibility with the read-only DVD.