gebhart/patrepeval huggingface dataset:
Small non-coding RNA and cancer (2017)

The ENCODE project has reported that at least 80% of the human genome is biologically active, yet only a small part of human DNA encodes for protein. The massive amount of RNA transcribed but not translated into protein can be classified as housekeeping RNA (such as rRNA, tRNA) and regulatory RNA (such as miRNA, piRNA, lncRNA). Small non-coding RNAs, in particular, have been the focus of many studies in the last 20 years and their fundamental role in many human diseases is currently well established. Inter alia, their role in cancer development and progression, as well as in drug resistance, is being increasingly investigated. In this review, focusing our attention on recent research results, we provide an overview of the four large classes of small non-coding RNAs, namely, miRNAs, piRNAs, snoRNA and the new class of tRNA-derived fragments, highlighting their fundamental role in cancer and their potential as diagnostic and prognostic biomarkers. microRNAs microRNA are 22nt-long non-coding RNA molecules, highly conserved and present in all eukaryotic cells. As of June 2014,
Crystal Structure–Ionic Conductivity Relationships in Doped Ceria Systems (2009)

In the past, it has been suggested that the maximum ionic conductivity is achieved in ceria, when doped with an acceptor cation that causes minimum distortion in the cubic fluorite crystal lattice. In the present work, this hypothesis is tested by measuring both the ionic conductivity and elastic lattice strain of 10 mol% trivalent cation‐doped ceria systems at the same temperatures. A consistent set of ionic conductivity data is developed, where the samples are synthesized under similar experimental conditions. On comparing the grain ionic conductivity, Nd 0.10 Ce 0.90 O 2−δ exhibits the highest ionic conductivity among other doped ceria systems. The grain ionic conductivity is around 17% higher than that of Gd 0.10 Ce 0.90 O 2−δ at 500°C, in air. X‐ray diffraction profiles are collected on the sintered powder of all the compositions, from room temperature to 600°C, in air. From the lattice expansion data at high temperatures, the minimal elastic strain due to the presence of dopant is observed in Dy 0.10 Ce 0.90 O 2−δ . Nd 0.10 Ce 0.90 O 2−δ exhibits larger elastic lattice strain than Dy 0.10 Ce 0.90 O 2−δ with better ionic conductivity at intermediate temperatures. Therefore, it is shown that the previously proposed crystal structure–ionic conductivity relationship based on minimum elastic strain is not sufficient to explain the ionic conductivity behavior in ceria‐based system.
Gravitational Reflux Does Not Correlate with Clinical Status of Venous Stasis (1993)

Objective: To quantify venous reflux by a standard duplex ultrasound technique and correlate the data obtained with clinical grades of severity of venous disease. Design: A prospective study in a single group of patients with venous insufficiency. Setting: Private practice in secondary and tertiary care. Patients: 133 inpatients undergoing investigation for venous disease. Patients with known venous obstruction, arterio-venous malformations or lymphoedema were excluded from the study. Main outcome measures: Duplex ultrasound scanning was performed to measure the cross-sectional area, severity and duration of venous reflux following calf compression using a standardized technique. Results: Clinical classification assigned to each limb correlated with the presence of venous reflux, but not the quantity, velocity or duration of reflux in the veins studied. Presence of reflux and diameter of the vein studied correlated ( p&lt;0.001) in all the veins except the popliteal vein ( p &gt; 0.03). Conclusion: Quantification of venous reflux obtained by cuff deflation does not correlate with clinical severity of venous stasis, but does detect reflux accurately. This allowed greater saphenous sparing in nine limbs in 41 patients but proved the need for saphenous removal in seven limbs not previously suspected clinically of requiring this procedure.
Triazines, Tetrazines and Fused Ring Polyaza Systems (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Impact of Threading Dislocations on the Design of GaAs and InGaP/GaAs Solar Cells on Si Using Finite Element Analysis (2012)

We investigate the impact of threading dislocation densities on the photovoltaic performance of single-junction (1J) n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> /p GaAs and dual-junction (2J) n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> /p InGaP/GaAs solar cells on Si substrate. Using our calibrated model, simulation predicts an efficiency of greater than 23% for a 1J GaAs cell on Si at AM1.5G spectrum at a threading dislocation density of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> . The design of a metamorphic 2J InGaP/GaAs solar cell on Si was optimized by tailoring the 2J cell structure on Si to achieve current matching between the subcells, taking into account a threading dislocation density of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> . Finally, we present a novel and an optimized 2J InGaP/GaAs solar cell design on Si at a threading dislocation density of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> , which exhibited a theoretical conversion efficiency of greater than 29% at AM1.5G spectrum, indicating a path for viable III-V multijunction cell technology on Si.
Multiple bonds between main-group elements and transition metals. 104. (.sigma.-Aryl)trioxorhenium(VII) complexes: syntheses, structural characterization, and properties (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple bonds between main-group elements and transition metals. 104. (.sigma.-Aryl)trioxorhenium(VII) complexes: syntheses, structural characterization, and propertiesClaude De Meric de Bellefon, Wolfgang A. Herrmann, Paul Kiprof, and Claire R. WhitakerCite this: Organometallics 1992, 11, 3, 1072–1081Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://pubs.acs.org/doi/10.1021/om00039a012https://doi.org/10.1021/om00039a012research-articleACS PublicationsRequest reuse permissionsArticle Views309Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking (2017)

These data show that procoagulant phospholipid exposure is not sufficient and that TF affinity maturation is required to generate prothrombotic microvesicles from a variety of cell types. These findings are significant for understanding TF-initiated thrombosis and should be considered in designing functional microvesicles-based diagnostic approaches.
Mutation Analysis of 3 Genes in Patients With Leber Congenital Amaurosis (2000)

Molecular diagnosis can confirm and clarify the diagnosis of LCA. As genotype data accumulate, clinical phenotypes associated with specific mutations will be established. This will facilitate the counseling of patients on their visual prognosis and the likelihood of associated systemic anomalies.
Modified Godard Algorithm Applied on a Fractional Oversampled Signal to Correct CD, Polarization, and CFO (2016)

Blind CD, polarization, and CFO correction in the frequency domain using the modified Godard algorithm is shown. The algorithm operates before clock recovery on a signal with &lt; 2 oversampling and is modulation format independent.
Novel miniature motors with lateral stator for a wide torque and speed range (2010)

For various drilling applications where the space in the tool head is limited, two motor topologies with the stator outsourced from the head are proposed, allowing for compact design and direct drive. In order to meet the high torque requirements at low speed and operate at high speed up to 200 000 rpm a finite element analysis (FEA) is carried out and the machine design is optimized for maximum torque while considering the space limitations and the loss constraints at the critical operating points. As an example, for the specifications of a high-speed micro-machining spindle covering a wide application range, FEA results are presented. Moreover, a torque ripple compensation method based on phase current profiles obtained from FEA is proposed to eliminate the torque ripple caused by the stator asymmetry and slotting.
Impact of ammonia treatment and platinum group or nickel metal decoration on the activated carbon storage of carbon dioxide and methane (2022)

Abstract Greenhouse gases, chiefly carbon dioxide (CO 2 ) and methane (CH 4 ), emission is responsible for the global warming and heat waves which strike the world causing floods and droughts everywhere with more CO 2 attributions. The adsorption and desorption capacities of CO 2 and CH 4 at room temperature and up to 5.0 and 100 bar, respectively, were investigated for the untreated and ammonia-treated activated carbons (ACs), metal-anchored (metal: Ru, Rh, Pd, Ir or Ni) samples. We merged ammonia treatment and metal decoration to discover their influences on the CO 2 and CH 4 storage capability of ACs and the potential use of such modified ACs for capturing greenhouse gases and purifying natural gas from CO 2 . The CO 2 storage capacities ranged between 25.2 and 27.7 wt% at 5.0 bar with complete regeneration upon desorption, while the uptakes for CH 4 were in the range of 9.6 − 12.6 wt% at 35 bar with hysteresis behavior of the adsorbed gas. The highest adsorption capacities were achieved for the pristine samples, showing that metal decoration reduced slightly the adsorption. Ammonia-treated samples showed minor enhancing effect on the CH 4 adsorption in comparison to the CO 2 adsorption. The higher adsorption capacities of CO 2 than those of CH 4 could be employed for upgrading the natural gas, while the 9.6 wt% (2.2 mmol g −1 ) CO 2 storage capacity would allow for its removal from the flue gases at ambient temperature and pressure. The higher adsorption capacity and preferentiality of CO 2 over CH 4 could be attributed mainly to its higher quadrupole moment and its higher clustering above the AC surfaces, while a minor effect, if any, would be attributed to the modifications of the ACs, implying that physisorption mechanism acted significantly in the adsorption process in comparison to chemisorption mechanism at the studied conditions.
Supplementary Figures 1 - 5, Methods from Globo-H Ceramide Shed from Cancer Cells Triggers Translin-Associated Factor X-Dependent Angiogenesis (2023)

&lt;p&gt;Supplementary Figure S1. Globo-H expression on breast cancer cells and shedding of GHCer from MDA-MB-157 cells into MVs. Supplementary Figure S2. Structure of TRAX, PLCβ1 and Globo-H. Supplementary Figure S3. Prediction of secondary structure of PLCβ1. Supplementary Figure S4. Amino-acid sequence alignment of PLCβ1 and PLCβ3. Supplementary Figure S5. Prediction of TRAX-PLCβ1 binding complexes.&lt;/p&gt;
Glaze (2019)

Existing Internet of Things (IoT) solutions require expensive infrastructure for sending and receiving data. Emerging technologies such as ambient backscatter help fill this gap by enabling uplink communication for IoT devices. However, there is still no efficient solution to enable low-cost and low-power downlink communication for ambient backscatter systems. In this paper we present Glaze, a system that overlays data on existing wireless signals to create a new channel of downlink communication for IoT backscatter devices. In particular, Glaze uses a new technique that introduces small perturbations to existing signals to convey data. We evaluate the performance of Glaze and show how it can be used across wireless standards such as FM, TV, or Wi-Fi to communicate with devices with minimal impact on existing data transmissions.
Analysis of Protein Target Interactions of Synthetic Mixtures by Affinity-LC/MS (2017)

Analysis of interactions between molecules is of fundamental importance in life science research. In this study, we applied weak affinity chromatography, based on high-performance liquid chromatography and mass spectrometry, as a powerful tool for direct analysis of the components of a chemical reaction mixture for their binding to a target protein. As a demonstration of the potential of this method, we analyzed the binding of the compounds of the reaction mixture to the chaperone heat shock protein 90 (Hsp90). It was possible to analyze quantitatively the binding of the components of the mixture to the target independently from each other without any preceding process such as purification. This feature has wide implications in biological sciences as crude mixtures, either natural or synthetic, can be analyzed directly for their possible binding to a target. This method could lead to savings in costs and labor through shortening chemical research project development time.
Development of a sensitive untargeted liquid chromatography–high resolution mass spectrometry screening devoted to hair analysis through a shared MS2 spectra database: A step toward early detection of new psychoactive substances (2018)

Untargeted liquid chromatography-high resolution mass spectrometry (LC-HRMS) techniques have become indispensable tools for systematic toxicological analysis. They allow the research of an almost unlimited number of drugs within a single analytical cycle, but shared mass spectra libraries are still missing to identify newly marketed compounds, along with defined analytical procedures. This article describes the optimization, validation, and application of an untargeted screening method devoted to hair analysis using data-dependent analysis (DDA) and a shared HRMS database. This method used an ultra-high performance liquid chromatography coupled to a benchtop Orbitrap. Raw MS data were processed with Compound Discoverer software coupled to the mzCloud™ library. Optimizations were performed on blank hair spiked with 19 analytes having different physical and chemical properties. To validate the effectiveness of a shared spectra database, 20 compounds spectra were added and then retrospectively screened. Sensitivity and reliability were evaluated on 317 compounds of interest in toxicology. The method was then applied to 11 hair samples. The matrix effect range by ion suppression/enhancement was 40%-110%. The method allows the detection of 284 among the 317 screened compounds, including 72 new psychoactive substances (NPS). Lower limit of identification (LLOI) and lower limit of detection (LLOD) were 1 to 1000 pg/mg and 1 to 500 pg/mg, respectively. The method was successfully applied to 11 clinical cases and 144 compounds were identified including 24 NPS including AKB48-5F for the first time in hair. We developed and validated an LC-HRMS untargeted screening of 284 compounds and successfully applied it to 11 real hair samples.
Handheld simultaneous scanning laser ophthalmoscopy and optical coherence tomography system (2013)

Scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) are widely used retinal imaging modalities that can assist in the diagnosis of retinal pathologies. The combination of SLO and OCT provides a more comprehensive imaging system and a method to register OCT images to produce motion corrected retinal volumes. While high quality, bench-top SLO-OCT systems have been discussed in the literature and are available commercially, there are currently no handheld designs. We describe the first design and fabrication of a handheld SLO/spectral domain OCT probe. SLO and OCT images were acquired simultaneously with a combined power under the ANSI limit. High signal-to-noise ratio SLO and OCT images were acquired simultaneously from a normal subject with visible motion artifacts. Fully automated motion estimation methods were performed in post-processing to correct for the inter- and intra-frame motion in SLO images and their concurrently acquired OCT volumes. The resulting set of reconstructed SLO images and the OCT volume were without visible motion artifacts. At a reduced field of view, the SLO resolved parafoveal cones without adaptive optics at a retinal eccentricity of 11Â° in subjects with good ocular optics. This system may be especially useful for imaging young children and subjects with less stable fixation.
ChemInform Abstract: Preparation, Structure and Catalytic Properties of a Binuclear Pd(0) Complex with Bridging Silylene Ligands. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Buried Solvent Determines Both Anion-Binding Selectivity and Binding Stoichiometry with Hydrogen-Bonding Receptors (2005)

[reaction: see text] The crystal structure of a tetraurea picket porphyrin-chloride anion complex has previously shown the anion to be situated between two adjacent ureas and hydrogen bonded via four NH protons (J. Am. Chem. Soc. 1998, 120, 11684-11692). The porphyrin receptor also binds a DMSO molecule and utilizes it as a participant in its anion recognition unit, in a manner similar to enzymes that bind water for use as part of their substrate recognition unit. The bound solvent molecule determines the anion-binding affinity, selectivity, and stoichiometry of binding. With a bound DMSO molecule, the tetraurea picket porphyrin is a highly selective receptor for chloride anion and binds all anions with a 1:1 binding stoichiometry. Absent the buried DMSO molecule, the receptor is selective for phosphate anion and binds chloride and phosphate anions with both 1:1 and 1:2 receptor-anion stoichiometries. Additionally, a remarkable reversal in the selectivity of anion complexation between various picket porphyrin receptors is observed, wherein the binding constant ratios change over 3 orders of magnitude as the receptor's number of urea pickets change from four to two. The latter receptor has no urea pickets available to bind to solvent after complexation with an anion. The results demonstrate that anion complexation with hydrogen-bonding receptors in a competitive solvent is enhanced when a ubiquitous solvent molecule is incorporated into the binding motif. In this way, competitive solvent adds to the overall complexation energy and thereby strengthens binding rather than weakens it, as commonly believed. The results are pertinent to drug design, for they suggest that pharmaceuticals need not be completely desolvated to selectively bind to their biological target when water can be included in the binding motif.
Burning behavior and thermal degradation kinetics of surface photografted polyamide 6.6 fabric (2012)

Surface photografting with 2‐hydroxyethyl methacrylate phosphate has been used to improve the flame retardancy of polyamide 6.6 fabrics. Limiting oxygen index tests and vertical burning tests were used to characterize the fire performance. The highest limiting oxygen index value of the grafted sample can reach up to 31.2, which is 58% higher than that of the ungrafted fabric. The thermal stability and char morphology of the polyamide 6.6 fabrics have been characterized by the thermogravimetric analysis and scanning electron microscopy analysis. Kinetic analysis on fabric samples was investigated, and the results show that the activation energy of the grafted sample is higher than that of the ungrafted fabric. Copyright © 2012 John Wiley &amp; Sons, Ltd.
Chapter 4. Glucokinase Activators in Development (2012)

Type 2 diabetes mellitus (T2DM) is a rapidly expanding public health problem affecting over 220 million people worldwide.1 The disease is characterized by elevated fasting plasma glucose (FPG), insulin resistance, abnormally elevated hepatic glucose production (HGP), and reduced glucose-stimulated i...
The phagocytosis oxidase/Bem1p (PB1) domain-containing protein PB1CP negatively regulates the NADPH oxidase RBOHD in plant immunity (2020)

Summary Perception of pathogen-associated molecular patterns (PAMPs) by surface-localized pattern-recognition receptors activates RESPIRATORY BURST OXIDASE HOMOLOG D (RBOHD) through direct phosphorylation by BOTRYTIS-INDUCED KINASE 1 (BIK1) and induces the production of reactive oxygen species (ROS). ROS have direct antimicrobial properties but also serve as signaling molecules to activate additional defense responses such as stomatal closure. RBOHD activity must be tightly controlled to avoid the detrimental effects of ROS, but little is known about RBOHD downregulation. To better understand the regulation of RBOHD, we used co-immunoprecipitation of RBOHD coupled with mass spectrometry analysis to identify RBOHD-associated proteins. Among RBOHD-associated proteins, we identified PHAGOCYTOSIS OXIDASE/ BEM1P (PB1) DOMAIN-CONTAINING PROTEIN (PB1CP). We found that PB1CP negatively regulates RBOHD and the resistance against the fungal pathogen Colletotrichum higginsianum . PB1CP directly interacts with RBOHD in vitro , and PAMP treatment increases the interaction in vivo . PB1CP is localized at the cell periphery and in cytoplasm, but PAMP treatment induces PB1CP relocalization to small endomembrane compartments. PB1CP overexpression reduces plasma membrane localization of RBOHD, suggesting that PB1CP down-regulates RBOHD function by relocalizing it away from the plasma membrane. We reveal a novel negative regulation mechanism of ROS production through the relocalization of RBOHD by PB1CP.
Computer code for fast macromodeling of large multiport systems (2008)

Vector fitting is a robust macromodeling technique for transfer function synthesis in the frequency domain. This paper introduces a new MATLAB routine, called vectfit3.m, which is an implementation of the fast relaxed vector fitting (Fast RVF) method. This routine computes a common-pole rational function approximation from tabulated frequency responses and combines the benefits of relaxation and a fast implementation of the pole-identification step. It is intended to replace the previous vectfit2.m routine, because it is significantly more efficient when fitting common-pole transfer matrices with a large number of elements.
Demonstration of efficient spin injection in a CW VECSEL at RT and dynamic control of its polarization state (2016)

We report the first efficient spin injection in a CW optically pumped VECSEL, obtained with phase anisotropy dynamic control. A threshold reduction of 1.5 % and an ellipticity of 75% are obtained at RT. Theoretical and experimental investigation of the polarization eigenstates is presented.