gebhart/patrepeval huggingface dataset:
Antiatheromatic and hypolipidemic activity of Chios Mastic Gum in anesthetized rabbits (2008)

Chios Mastic gum, the resin of the trunk and branches of Pistacia lentiscus var. chia (Anacardiaceae), has been used since antiquity in traditional greek medicine. The main compounds of mastic are triterpenes, both acidic and neutral. Tirucallol and butyrospermol, the main neutral components, possess phytosterolic structure. This led to the hypothesis that mastic and particularly its neutral phytosterolic fraction could possess antiatheromatic activities. Mastic Total Extract without Polymer (TMEWP) and the phytosterolic fraction (Neutral Mastic Fraction, NMF), were administered to rabbits in the form of sunflower oil solution for 6 weeks. Anesthetized rabbits were subjected to 30min regional ischemia of the heart, followed by 3 hrs of reperfusion and were randomized into 6 groups: Normal fed animals: Control group, Group A, treated with 46.3mg/(kg-d) of TMEWP, Group B, treated with 45.8mg/(kg-d) of NMF. Animals fed with cholesterol-enriched diet: CHOL group, Group C, treated with 46.3mg/(kg-d) of TMEWP, Group D, treated with 45.8mg/(kg-d) of NMF. At the end of the experiment the infarct size was determined and small segments of the ascending and descending aorta and the heart were taken for histologic examination. Blood samples were collected at several time points, for malondialdehyde (MDA) and for total cholesterol determination. NMF reduced the infarct size (18.3±3.4%, P<0.05), while the administration of TMEWP did not reduce the infarct size significantly (30.3±4.7% vs. 47.0±1.9% in the control group) in the normal fed rabbits. In the hypercholesterolemic rabbits no reduction on infarct size was observed by both treatments. There was no detection of atherogenesis in the form of subintimal accumulation of lipids and foamy macrophages in Group A and Group B. TMEWP and NMF reduced the total cholesterol concentration by 47 and 88% respectively (P<0.01). MDA levels were elevated in all study groups at the 20th min of reperfusion. Long –term treatment of Mastic Total Extract and the phytosterolic fraction possesses significant antiatheromatic and hypolipidemic activities in the hypercholesterolemic rabbits in vivo. The phytosterolic fraction reduces significant the infarct size in the normal fed rabbits.
Controlled nucleation of hydroxyapatite on alginate scaffolds for stem cell‐based bone tissue engineering (2010)

Current bone tissue engineering strategies aim to grow a tissue similar to native bone by combining cells and biologically active molecules with a scaffold material. In this study, a macroporous scaffold made from the seaweed-derived polymer alginate was synthesized and mineralized for cell-based bone tissue engineering applications. Nucleation of a bone-like hydroxyapatite mineral was achieved by incubating the scaffold in modified simulated body fluids (mSBF) for 4 weeks. Analysis using scanning electron microscopy and energy dispersive x-ray analysis indicated growth of a continuous layer of mineral primarily composed of calcium and phosphorous. X-ray diffraction analysis showed peaks associated with hydroxyapatite, the major inorganic constituent of human bone tissue. In addition to the mineral characterization, the ability to control nucleation on the surface, into the bulk of the material, or on the inner pore surfaces of scaffolds was demonstrated. Finally, human MSCs attached and proliferated on the mineralized scaffolds and cell attachment improved when seeding cells on mineral coated alginate scaffolds. This novel alginate- HAP composite material could be used in bone tissue engineering as a scaffold material to deliver cells, and perhaps also biologically active molecules.
Optics enabled networks and architectures for data center cost and power efficiency [Invited] (2021)

Bandwidth demand for data center networks continues as performance increases and is further fueled by the exploding demand for artificial intelligence and new high-performance computing workloads. Managing power and costs will require a range of solutions including new networking and workload specialized architectures, composable systems, and optical circuit switching. In this paper, we focus primarily on two topics: examining the benefits of flatter networks (enabled mainly by means of co-packaged-optics-enabled switches) and the utilization improvement potential for composable (disaggregated) systems, while discussing specialized hardware and networks, and optical circuit switching more briefly.
Emotional arousal estimation while reading comics based on physiological signal analysis (2016)

Estimating emotions while reading enables new services such as comic recommendation. Most of existing emotion estimation systems employ bulky devices. Furthermore, few applications have been developed for analyzing the emotions while reading. The purpose of our research is to develop a method for estimating emotions while reading. As the target of reading, we select comics, which stimulate emotions often more than other types of documents. As we want our system to be easily usable, we selected sensors embedded in a wristband and an eye tracker. Emotions can be described by two dimensions called emotional valence and arousal. As a first step, we propose in this paper to estimate the emotional arousal. We analyze the electrodermal activity, blood volume pulse, heart rate, skin temperature and pupil diameter of a subject to estimate if the reader feels a high or low arousal while reading. Our experiment shows that for some participants, the arousal can be estimated accurately.
Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Tear Production in a Mouse Model of Sjögren’s Syndrome (2017)

The purpose of the present study was to test the potential of mouse bone marrow-derived mesenchymal stem cells (BD-MSCs) in improving tear production in a mouse model of Sjögren's syndrome dry eye and to investigate the underlying mechanisms involved. NOD mice (<i>n</i> = 20) were randomized to receive i.p. injection of sterile phosphate buffered saline (PBS, control) or murine BD-MSCs (1 × 10<sup>6</sup> cells). Tears production was measured at baseline and once a week after treatment using phenol red impregnated threads. Cathepsin S activity in the tears was measured at the end of treatment. After 4 weeks, animals were sacrificed and the lacrimal glands were excised and processed for histopathology, immunohistochemistry, and RNA analysis. Following BD-MSC injection, tears production increased over time when compared to both baseline and PBS injected mice. Although the number of lymphocytic foci in the lacrimal glands of treated animals did not change, the size of the foci decreased by 40.5% when compared to control animals. The mRNA level of the water channel aquaporin 5 was significantly increased following delivery of BD-MSCs. We conclude that treatment with BD-MSCs increases tear production in the NOD mouse model of Sjögren's syndrome. This is likely due to decreased inflammation and increased expression of aquaporin 5.
Make C sub 3 -C sub 4 olefins selectively (1990)

When the demand for C{sub 3} olefin, a specific C{sub 4} olefin or group of these, exceeds the amount available as byproduct from existing processes, a more selective process is preferred. The Oleflex catalytic dehydrogenation process represents an economical method to produce propylene and butenes in high selectivities from the corresponding paraffin. The process can be operated as a stand-alone unit or integrated in a new or existing olefin complex. This article outlines several different processing schemes that incorporate the Oleflex process.
Ru-Doped Wells–Dawson Polyoxometalate as Efficient Catalyst for Glycerol Hydrogenolysis to Propanediols (2019)

A Ru-doped phospho-tungstic Wells-Dawson polyoxometalate (POM) was successfully applied as homogeneous catalyst for glycerol hydrogenolysis in aqueous media. The synthesized compound showed superior catalytic activity compared to classical homogeneous/heterogeneous Ru catalysts like RuCl<sub>3</sub> and Ru/C under identical reaction conditions, whereas the analogous POM doped with Pd or Pt proved far less activity. Detailed characterization of the POMs was performed using <sup>31</sup>P-NMR to identify characteristic phosphorous peaks of the heteroatoms, infrared spectroscopy (ATR-FTIR) to confirm characteristic P-O and W-O-W vibrations, powder XRD for comparison of crystal structures, and X-ray fluorescence (XRF) and inductive-coupled plasma (ICP) analysis to determine elemental composition. Variation of the reaction parameters for the best performing Ru-doped POM catalyst showed that substrate concentration played an important role for both product selectivity and conversion. Moreover, medium hydrogen pressure and high stirring speed were key factors to obtain highly selective conversion of glycerol to 1,2-propanediol.
Oligomer Assembly of the C-Terminal DISC1 Domain (640−854) Is Controlled by Self-Association Motifs and Disease-Associated Polymorphism S704C (2009)

Genetic studies have established a role of disrupted-in-schizophrenia-1 (DISC1) in chronic mental diseases (CMD). Limited experimental data are available on the domain structure of the DISC1 protein although multiple interaction partners are known including a self-association domain within the middle part of DISC1 (residues 403-504). The DISC1 C-terminal domain is deleted in the original Scottish pedigree where DISC1 harbors two coiled-coil domains and disease-associated polymorphisms at 607 and 704, as well as the important nuclear distribution element-like 1 (NDEL1) binding site at residues 802-839. Here, we performed mutagenesis studies of the C-terminal domain of the DISC1 protein (residues 640-854) and analyzed the expressed constructs by biochemical and biophysical methods. We identified novel DISC1 self-association motifs and the necessity of their concerted action for orderly assembly: the region 765-854 comprising a coiled-coil domain is a dimerization domain and the region 668-747 an oligomerization domain; dimerization was found to be a prerequisite for orderly assembly of oligomers. Consistent with this, disease-associated polymorphism C704 displayed a slightly higher oligomerization propensity. The heterogeneity of DISC1 multimers in vitro was confirmed with a monoclonal antibody binding exclusively to HMW multimers. We also identified C-terminal DISC1 fragments in human brains, suggesting that C-terminal fragments could carry out DISC1-dependent functions. When the DISC1 C-terminal domain was transiently expressed in cells, it assembled into a range of soluble and insoluble multimers with distinct fractions selectively binding NDEL1, indicating functionality. Our results suggest that assembly of the C-terminal domain is controlled by distinct domains including the disease-associated polymorphism 704 and is functional in vivo.
Convenient Synthesis of Functional Polyfluorenes via a Modified One-Pot Suzuki−Miyaura Condensation Reaction (2009)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTConvenient Synthesis of Functional Polyfluorenes via a Modified One-Pot Suzuki−Miyaura Condensation ReactionRyan M. Walczak†‡, Robert N. Brookins†, Alice M. Savage†, Eveline M. van der Aa†, and John R. Reynolds*†View Author Information The George and Josephine Butler Polymer Research Laboratory, Department of Chemistry, Center for Macromolecular Science and Engineering, University of Florida, Gainesville, Florida 32611, and nRadiance LLC, 18 Hunter Road, Suite 3, Hilton Head Island, South Carolina 29926* Corresponding author. E-mail: [email protected]†University of Florida.‡nRadiance LLC.Cite this: Macromolecules 2009, 42, 5, 1445–1447Publication Date (Web):February 16, 2009Publication History Received3 November 2008Revised22 January 2009Published online16 February 2009Published inissue 10 March 2009https://pubs.acs.org/doi/10.1021/ma802462vhttps://doi.org/10.1021/ma802462vrapid-communicationACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views2287Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Central nervous system,Organic compounds,Palladium,Polymerization,Polymers Get e-Alerts
Determination of the Model for the Chemical Structure of Porous PECVD Low-k Films (2014)

Scaling of Cu interconnect structures requires insulating materials with a low dielectric constant that also have adequate mechanical characteristics and good chemical resistance. These macro characteristics depend on the actual mechanical and chemical nanostructure of the porous low-k films. Unfortunately, there is no direct way to determine this exact nanostructure; e.g. neither Atom Probe nor Transmission Electron Microscopy are able to produce adequate images of an amorphous, porous low-k film. In this paper, we propose a new model for the chemical structure of PECVD low-k films: a strong hydrophobic layer, consisting of methyl groups covers the top surface of the porous film; besides, the pore walls are also covered with hydrophobic methyl groups. With this model, we are able to explain the macro characteristics of the low-k films. The model is supported by the test results obtained by modifying the top surface and immersing the pristine and modified films into diluted HF solutions.
Quorum sensing in Aliivibrio wodanis 06/09/139 and its role in controlling various phenotypic traits (2021)

<i>A. wodanis</i> 06/09/139 use QS to regulate a number of activities that may prove important for host colonization or interactions. The temperature of 6 °C that is in the temperature range at which winter ulcer occurs, plays a role in AHL production and development of CPE on a Chinook Salmon Embryo (CHSE) cell line.
Systematic Review and Individual Patient Data Meta-Analysis Of Treatment-Related Risk Of Secondary Malignant Neoplasms After Hodgkin Lymphoma (2013)

Abstract Introduction Secondary malignant neoplasms (SMN) are a major late effect of treatment for Hodgkin lymphoma (HL). Single trials have inadequate power to detect differences in SMN rates, while the many large-scale cohort-based studies of SMN after HL suffer from non-randomised, potentially biased comparisons of treatment strategies. The consequences of choice of first-line treatment for SMN risk remain unclear. We performed a Cochrane systematic review addressing this question based on our previous such review in 2000-2004. Material and methods Individual patient data (IPD) were collected from randomised controlled trials testing 5 currently relevant experimental strategies: avoidance of additional radiotherapy (RT) after chemotherapy (CT); reduction of RT field; reduction of RT dose; use of fewer CT cycles; intensification of CT regimen. All trials employed modern ABVD-like regimens and limited radiation fields, and recruited at least 50 patients per treatment group. Incidence of SMN, overall survival (OS) and progression-free survival (PFS) were analysed. Due to small numbers of events, SMN was analysed using Peto’s method. Results and Discussion Data from 16 of the 21 eligible trials were obtained, including 9498 patients. These trials recruited between 1984 and 2007 and randomised between 100 and 1351 patients each. Standard chemotherapy was predominantly ABVD, followed by COPP/ABVD and MOPP/ABV. Most frequent intensified chemotherapies were escalated BEACOPP and Stanford V. For each study question, key information and resulting odds ratios are shown in the table. Avoidance of additional RT significantly reduced the SMN risk (Peto odds ratio 0.433, 95% confidence interval (0.28; 0.82), p=0.010). Intensified chemotherapy regimens were associated with a consistent slightly higher risk but the effect was not significant. Other study questions showed no marked effects on SMN risk. Regarding solid tumors, follow-up is still too short: an update after 5 to 10 years is necessary. Disclosures: No relevant conflicts of interest to declare.
Novel Ga(NAsP)-Based Heterostructures for the Integration of Optoelectronic Functionalities on (001) Si-Substrate (2010)

The novel direct band gap, dilute nitride Ga(NAsP)-material system allows for the first time the monolithic integration of a III/V laser material lattice matched to Si substrate. This lattice-matched approach offers the possibility for a high-quality, low defect density integration of a III/V-laser material potentially leading to long-term stable laser devices on Si-substrate. The broad area laser structures consist of pseudomorphically strained active Ga(NAsP)/(BGa)(AsP) multi-quantum-well heterostructures (MQWHs) embedded in thick doped (BGa)P waveguide layers, grown by a specific low-temperature metal organic vapour phase epitaxy (MOVPE) process on (001) Si-substrate. This paper will present and discuss the current status of the material and device optimization to realise electrical injection laser diodes as a basis for Si-photonics based optoelectronic integrated circuits (OEICs) with novel functionalities.
Intensity of side effects of topical glaucoma medication and its influence on adherence behavior in patients with glaucoma (2014)

This study could not detect any significant influence of the subjectively experienced intensity of side effects on patients' adherence behavior. However, we believe that a simple and clear treatment plan with few side effects is still preferred by most patients.
Surface Micromachined Out-of-plane Electrostatic MEMS Actuator Integrated with Displacement Sensor (2021)

We propose an out-of-plane electrostatic MEMS actuator capable of sensing its displacement. A repulsive force electrostatic arm is designed to form an actuator that push a suspended plate away from the substrate. A single capacitance sensing electrode is located beneath the moveable plate to measure the actuator vertical displacement. We demonstrate that the actuator, which was fabricated using a standard surface micromachining process, can provide a vertical displacement of 1.8 µm when excited with a 50 V DC voltage. This movement results in a reduction of the sensing electrode capacitance. Hence, the displacement of the actuator can be monitored as a function of the change in capacitance at the sensing electrode. This self-sensing feature allows the actuator to be utilized in closed-loop control systems as well as self-aligned optical platforms.
Beyond Accuracy: The Role of Mental Models in Human-AI Team Performance (2019)

Decisions made by human-AI teams (e.g., AI-advised humans) are increasingly common in high-stakes domains such as healthcare, criminal justice, and finance. Achieving high team performance depends on more than just the accuracy of the AI system: Since the human and the AI may have different expertise, the highest team performance is often reached when they both know how and when to complement one another. We focus on a factor that is crucial to supporting such complementary: the human’s mental model of the AI capabilities, specifically the AI system’s error boundary (i.e. knowing “When does the AI err?”). Awareness of this lets the human decide when to accept or override the AI’s recommendation. We highlight two key properties of an AI’s error boundary, parsimony and stochasticity, and a property of the task, dimensionality. We show experimentally how these properties affect humans’ mental models of AI capabilities and the resulting team performance. We connect our evaluations to related work and propose goals, beyond accuracy, that merit consideration during model selection and optimization to improve overall human-AI team performance.
IgG immunoglobulins induce activation of the sphingomyelin cycle in HL‐60 cells (1996)

In HL-60 cells signal transduction via sphingomyelin hydrolysis (sphingomyelin cycle) is induced by binding of tumor necrosis factor alpha (TNFalpha) to cell surface TNFalpha receptor. We found that IgG immunoglobulins activate sphingomyelin hydrolysis in plasma membrane of HL-60 cells, with kinetics similar to that of activation by TNFalpha. Activation was induced by different IgG isotypes (most of which are irrelevant to known inducers of the sphingomyelin cycle) and also by Fcgamma fragments of IgG. The facts that inhibiting the binding of the antibodies to the cell surface by protein A prevents activation of sphingomyelin hydrolysis and that soluble TNF receptor of 55-kDa subtype (TBP55) inhibits activation, suggest that the mechanism of IgG-induced sphingomyelin hydrolysis involves binding of IgGs through their Fcgamma domain to Fcgamma surface receptors which mediate autocrine secretion of TNFalpha. The latter is responsible for inducing sphingomyelin hydrolysis. This study suggests that TBP55 may be an effective inhibitor of the sphingomyelin cycle.
Optical DFG-based 60 GHz signal generation by using a LiTaO<sub>3</sub> rectangular waveguide (2014)

Millimeter-wave (MMW) signal generation devices using difference frequency generation (DFG) based on the second order nonlinear optical effect in a rectangular waveguide were studied in detail theoretically and experimentally. The temporal and spatial coupling process of a generated MMW signal to a TE10 mode in a rectangular waveguide embedded with a nonlinear crystal was analyzed using the finite-difference time-domain (FDTD) method. In the experiment, 60 GHz-band signals were successfully obtained from fabricated proto-type devices using a rectangular waveguide embedded with z-cut LiTaO3 crystal.
Ureteric Stenting After Ureteroscopy for Ureteric Stones: A Prospective Randomized Study Assessing Symptoms and Complications (2005)

No AccessJournal of UrologyUrological Survey: Urolithiasis, Endourology and Laparoscopy1 Jun 2005Ureteric Stenting After Ureteroscopy for Ureteric Stones: A Prospective Randomized Study Assessing Symptoms and Complications Ralph V. ClaymanM.D. Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1097/01.ju.0000161378.79273.b3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Ureteric Stenting After Ureteroscopy for Ureteric Stones: A Prospective Randomized Study Assessing Symptoms and Complications." The Journal of Urology, 173(6), p. 2022 © 2005 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 173Issue 6June 2005Page: 2022 Advertisement Copyright & Permissions© 2005 by American Urological Association, Inc.MetricsAuthor Information Ralph V. Clayman More articles by this author Expand All Advertisement PDF DownloadLoading ...