gebhart/patrepeval huggingface dataset:
Association of Leishmania heat shock protein 83 antigen and immunoglobulin G4 antibody titers in Brazilian patients with diffuse cutaneous leishmaniasis (1997)

Diffuse cutaneous leishmaniasis (DCL) is characterized by the presence of numerous nonulcerated nodules and plaques containing large numbers of Leishmania amazonensis parasites and few lymphoid elements. The immune responses of DCL patients reflect severe antigen-specific T-cell deficiencies, while the antibody response to Leishmania antigens is often accentuated. We report herein on the Leishmania antigen-specific antibody subclass distribution in DCL patients and demonstrate that a dominant antigen contributing to the biased immunoglobulin G4 antibody subclass in sera of DCL patients is Leishmania heat shock protein 83.
Progress in Development of a Converging Beam Neutron Source for Driving a Sub-Critical Fission Reactor (2002)

Several laboratories are studying the possibility of a fission reactor system based on driving a sub-critical assembly using an accelerator-spallation target neutron source. The objective is to effectively eliminate possible criticality and meltdown accidents, increasing plant safety. However, one disadvantage is the large cost projected for the accelerator-driven source. In an ICONE-8 paper we proposed to overcome this problem by use of a Converging Beam Neutron Source (CBNS) to produce 14-MeV D-T fusion neutrons to drive the sub-critical core. [1] The CBNS is analogous to an accelerator-plasma target device with built-in re-circulation of the ions. It offers the unique advantage of being small enough to allow insertion of multiple “modular” units in fuel channel locations (cf. the large single target used in accelerator-drive designs). As proposed in an ICONE-9 paper, a first important step in development of such systems might be use in low power research reactors. [2] This reduces the neutron source strength requirement to a level only slightly above that obtained with present IEC experiments. Still, a key step for CBNS development is to increase the neutron production efficiency obtained in previous small-scale experiments. To do this we have recently developed a unique RF-driven ion source so that the ion production region can be separated from the main CBNS chamber. This has the combined advantages of allowing ion production at relatively high pressure, while the CBNS chamber can be pumped to ultra-low pressure. Initial experiments with this arrangement are presented here and it is shown that a very favorable scaling to the yields required for research reactor operation are predicted.
Low temperature process for strontium bismuth tantalate thin films (2000)

Abstract As CMOS dimensions shrink so does the limitation on total thermal budget for processing. For 0.18 μm design rules, the junction depth and the salicide process requirements limit the maximum processing temperature to below 700°C, preferably down to 650°C. For FeRAMs, this results in limitation on the thermal budget available for the crystallization of ferroelectric films. SBT and SBTN films have been generally annealed at 700°C or higher. Lowering the crystallization temperature down to 650°C requires the suppression of fluorite phase in order to obtain good ferroelectric performance. We have developed a CSD based low temperature process for SBT films yielding excellent ferroelectric properties. Several materials and process parameters have been optimized to suppress the fluorite phase. These include film stoichiometry and thickness, anneal ambient and ramp rates, UV energy and precursor solvents. In this paper we present a complete 650°C process for SBT thin films, highlighting process modifications and their effect on ferroelectric performance.
Comprehensive audiological assessment system (1997)

A new approach to comprehensive audiometry is introduced. This new concept of audiological assessment makes it possible to perform a battery of tests at the same work station during a single visit of the patient. An integrated audiometric instrument, the Audiological Assessment System, is also designed. This system saves clinic space. It is easy and convenient to use due to uniformity and similarity of an operator interface to that in conventional arrangements. Maintenance, service, calibration and upgrading of the system is a one-step process. Thus it is time- and cost-effective. The system enables effective handling of clinical data.
Experimental Investigation of Laser-Assisted Thermoplastic Tape Consolidation (1988)

An experimental investigation of a novel approach for manufacturing of thermoplastic matrix composites, is described. The technique is based on using laser energy as the focused heat source to melt the matrix material for subsequent consolidation, and appears to be particularly suited for thermoplastic filament winding operations. An experimental set up is defined to produce multi ply rings, and the feasibility of this technique is demon strated by discussing several samples that were produced using Ryton AC40-60 prepreg tapes. The quality of consolidation is examined through cross-sectional micrographs.
Improved Results of Surgical Management of Postinfarction Ventricular Septal Rupture (1982)

Fifty-five patients had surgical repair of postinfarction ventricular septal rupture in Massachusetts General Hospital from 1968 through 1981. In patients operated more than three weeks after infarction, hospital survival has been 93% (14/15). Before 1975 in patients operated less than three weeks after infarction, hospital survival was 41% (7/17). In this same era patents operated for septal rupture with cardiogenic shock present before operation had a hospital survival rate of only 27% (3/11). Before 1975 patients with cardiogenic shock were supported with intra-aortic balloon pumping (IABP) and vasopressors, and operation deferred pending hemodynamic stabilization. Before 1975 patients with anterior septal rupture had a hospital survival rate of 64% (9/14), while patients with posterior septal rupture had a hospital survival rate of only 38% (5/13). This difference in survival according to the location of septal rupture occurred despite comparable numbers of patients in each group requiring early operation, as well as incidence of cardiogenic shock. Since January 1, 1975 patients operated less than three weeks after infarction have had an overall hospital survival rate of 70% (16/23). Of the 10 most recent patients operated early, nine are survivors. In patients with anterior defects 85% (11/13) survived, while in patients with posterior defects 67% survived (10/15). In patients operated with cardiogenic shock present before operation, survival has been 67% (10/15). Changes in management leading to improved results include (1) immediate operation for patients with cardiogenic shock, (2) cold cardioplegic protection of the myocardium, and (3) prosthetic replacement of posterior left ventricular free wall defect, after infarctectomy and septal repair, in patients with posterior septal rupture.
860: Prostate Stem Cell Antigen (PSCA) Expression is Associated with Gleason Score, Seminal Vesicle Invasion, and Capsular Invasion in Prostate Cancer (2004)

You have accessJournal of UrologyDiscussed Poster, Monday, May 10, 2004, 8:00 am - 12:00 pm1 Apr 2004860: Prostate Stem Cell Antigen (PSCA) Expression is Associated with Gleason Score, Seminal Vesicle Invasion, and Capsular Invasion in Prostate Cancer Ken Han, David B. Seligson, Xueli Liu, Steve Horvath, Peter I. Shintaku, George V. Thomas, Jonathan W. Said, and Robert E. Reiter Ken HanKen Han More articles by this author , David B. SeligsonDavid B. Seligson More articles by this author , Xueli LiuXueli Liu More articles by this author , Steve HorvathSteve Horvath More articles by this author , Peter I. ShintakuPeter I. Shintaku More articles by this author , George V. ThomasGeorge V. Thomas More articles by this author , Jonathan W. SaidJonathan W. Said More articles by this author , and Robert E. ReiterRobert E. Reiter More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)38109-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "860: Prostate Stem Cell Antigen (PSCA) Expression is Associated with Gleason Score, Seminal Vesicle Invasion, and Capsular Invasion in Prostate Cancer." The Journal of Urology, 171(4S), pp. 227–228 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 227-228 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Ken Han More articles by this author David B. Seligson More articles by this author Xueli Liu More articles by this author Steve Horvath More articles by this author Peter I. Shintaku More articles by this author George V. Thomas More articles by this author Jonathan W. Said More articles by this author Robert E. Reiter More articles by this author Expand All Advertisement PDF downloadLoading ...
‘Race’, Housing and the City (2018)

The analysis which follows stems from a growing concern at the apparent inability of the literature, both beyond the discipline and within it, to provide a convincing theorisation of the structural position of Britain's minority populations within the housing market. This chapter seeks to add to the theoretical literature, but not through an extension of existing, ultimately arid, conceptual debates. Employing summaries of detailed analyses of 1991 Census data, it aims to demonstrate that large-scale secondary data on factors such as tenure, dwelling type, amenities and levels of overcrowding can be used to interrogate existing theoretical debates. As to the sociological agenda, there is an urgent need to theorise the sociological dimensions of economic, social and demographic change. Despite the obvious problems created both by small sample sizes and by significant differences in age structure between these groups and the first-generation migrants, a few tentative conclusions can be reached.
Producing Technology of Aluminum Foam from Machined Chip Waste (2006)

The present study focuses on the investigation of the possibility of producing aluminum foam from low cost machined chip waste. To produce highly porous aluminum, manufacturing process of precursor, the effect of TiH2 content and the effect of ceramic particle addition were examined. In the study of precursor manufacturing processes, precursors fabricated by extrusion process did not expand sufficiently and the pore morphology was very irregular. In contrast, precursors fabricated by compressive torsion processing satisfactorily expanded and the pore morphology was uniform. There was an adequate range of TiH2 addition. The increase of TiH2 content more than 3 mass% was not an effective way to produce highly porous aluminum foam. Addition of fine Al2O3 particle resulted in a significant increase in foam expansion.
ESD protection techniques for semiconductor devices (2002)

Electrostatic discharges (ESD) are everywhere-in our homes, businesses and even at the manufacturers of the electronics we buy. The discharges cause failure of these electronic components. Presented here is a two pronged approach for ESD protection: reduce the likelihood of having an ESD event and improving the robustness of the devices. The first approach focuses on reducing the charge developed and controlling the redistribution of any charges that are developed. The second approach looks at ways to improve both the processes used to build electronics as well as the devices themselves.
Fabrication of micro holographic optical elements by interference of a single pulse from femtosecond laser (2001)

Summary form only given. By fully utilizing the unique features of femtosecond pulses from a mode locked Ti:sapphire laser such as short pulse duration, high energy density and good coherency, we have encoded micro-holographic optical elements (HOEs) either on or beneath material surfaces. The materials investigated include transparent dielectrics such as single crystals of Al/sub 2/O/sub 3/, SiC, LiNbO/sub 3/, ZrO/sub 2/, ZnO, CaF/sub 2/, CdF/sub 2/, MgO, and TiO/sub 2/, glasses, plastics and metals. Both surface relief type gratings and embedded gratings (refractive index modulation type) were fabricated, respectively, due to laser ablation at surfaces and laser induced structural alterations of materials such as the crystalline to amorphous phase change and chemical bond angle changes in silica glass.
High resolution microphotonic needle for endoscopic imaging (Conference Presentation) (2017)

GRIN (Graded index) lens have revolutionized micro endoscopy enabling deep tissue imaging with high resolution. The challenges of traditional GRIN lenses are their large size (when compared with the field of view) and their limited resolution. This is because of the relatively weak NA in standard graded index lenses. Here we introduce a novel micro-needle platform for endoscopy with much higher resolution than traditional GRIN lenses and a FOV that corresponds to the whole cross section of the needle. The platform is based on polymeric (SU-8) waveguide integrated with a microlens micro fabricated on a silicon substrate using a unique molding process. Due to the high index of refraction of the material the NA of the needle is much higher than traditional GRIN lenses. We tested the probe in a fluorescent dye solution (19.6 µM Alexa Flour 647 solution) and measured a numerical aperture of 0.25, focal length of about 175 µm and minimal spot size of about 1.6 µm. We show that the platform can image a sample with the field of view corresponding to the cross sectional area of the waveguide (80x100 µm2). The waveguide size can in principle be modified to vary size of the imaging field of view. This demonstration, combined with our previous work demonstrating our ability to implant the high NA needle in a live animal, shows that the proposed system can be used for deep tissue imaging with very high resolution and high field of view.
α-Synuclein in α-helical conformation at air–water interface: implication of conformation and orientation changes during its accumulation/aggregation (2010)

α-Synuclein, a natively unstructured protein important in the neuropathology of Parkinson's disease, was found to form a Langmuir monolayer in an α-helical conformation with its helical axis parallel to the air–water interface. This study sheds light on the role of vesicles in neuronal cells in the accumulation/aggregation of α-synuclein.
Super-resolução de vídeo usando quadros chave (2009)

Resumo-Diferentes sistemas de codificac o de vdeo com escalabilidade espacial codificam os quadros em distintas resoluc es para que possam ser obtidas diferentes camadas de decodificac o. Alguns desses sistemas tambm se utilizam da decimac o de quadros para reduzir complexidade, permitindo o uso de camadas de realce. Nesse contexto, mtodos de super-resoluc o de quadros associados a processos eficientes de interpolac o podem ajudar a melhorar a qualidade dos quadros codificados em baixa resoluc o espacial. Este trabalho apresenta uma tcnica de superresoluc o a partir de quadros chave. O objetivo recuperar a alta freq ncia dos quadros decimados a partir de quadros chaves codificados em alta resoluc o. Os quadros resultantes do processo de super-resoluc o
An Occupant Classification System Eigen Shapes or Knowledge-Based Features (2006)

This paper describes an occupant classification system based on Eigen shapes and support vector machines classification using 3D data. The occupant classification system is used to classify an occupant type into an adult, a child, a child seat, or an object. The inputs are depth images from a time-of-flight based depth camera. The images are first segmented from the background and normalized for threedimensional translations. The segmented images are projected into Eigen shapes that are constructed from a training set. The projections are used as feature vectors for a support vector machines classification algorithm. The Eigen features and support vector machines complement each other since the former is a linear transformation to reduce the dimensionality of the space, while the latter can deduce the non-linear aspects of these lower-dimensional features. Our experiments lead to several conclusions. First, we compare between Eigen shapes and knowledge based features, e.g. computer generated versus human generated features. The Eigen shapes provides better results compared to various combinations of knowledge-based features. The combination of Eigen shapes and knowledge-based features provide the best results, since both of these features capture different characteristics of images. The Comparison with intensity based analysis shows that the depth images are more suitable for this application. The support vector machines have also been shown to be superior to several other classification algorithms. The system provides more than 98 percent recognition rate with depth images as input. The failure cases include extreme deformations of the occupant that were not part of the training set.
URBANopt: An Open-Source Software Development Kit for Community and Urban District Energy Modeling: Preprint (2021)

Urban building modeling tools are developing rapidly; these tools use emerging simulation workflows for specific urban environmental design tasks, such as assessing the impacts of energy efficiency technologies at a district scale. However, with the emergence of new environmental design tasks, addressing all possible use cases and tasks is challenging and cannot be covered by a single tool. Urban-scale analysis at this level of complexity often requires linking multiple emerging tools, rather than using a single tool, to adequately evaluate a variety of possible fields in urban environmental design. To achieve this, flexible platforms are needed to support multiple input formats (e.g., geometric and non-geometric building properties), enabling the mapping of such inputs to underlying simulation engines. This paper provides an overview of the open-source URBANopt Software Development Kit (SDK) for modeling high-performance buildings and energy systems at a district scale. URBANopt's flexible SDK is composed of several modules that can be customized to integrate with other tools and generate new workflows to perform urban environmental design tasks, such as capturing interactions between individual buildings, district energy systems, distributed energy resources, and the electric distribution grid. We describe the functionality of the core SDK modules in URBANopt (called Core Gem, GeoJSON Gem, and Scenario Gem) and discuss the flexibility of these modules as a means of integration with a variety of tools. We also document and demonstrate technical details of writing and combining new modules to create customized workflows. Finally, we present a case study that uses the URBANopt SDK to model a hypothetical mixed-use urban project and simulate various scenarios to meet district energy performance goals.
Directed self-assembly patterning for forming fin field effect transistors (2016)

Silicon fins with a pitch less than 30nm and suitable critical dimensions for advanced field effect transistors are formed by directed self-assembly patterning via chemoepitaxy or self-aligned customization.
The Tick Salivary Protein Sialostatin L2 Inhibits Caspase-1-Mediated Inflammation during Anaplasma phagocytophilum Infection (2014)

Saliva from arthropod vectors facilitates blood feeding by altering host inflammation. Whether arthropod saliva counters inflammasome signaling, a protein scaffold that regulates the activity of caspase-1 and cleavage of interleukin-1β (IL-1β) and IL-18 into mature molecules, remains elusive. In this study, we provide evidence that a tick salivary protein, sialostatin L2, inhibits inflammasome formation during pathogen infection. We show that sialostatin L2 targets caspase-1 activity during host stimulation with the rickettsial agent Anaplasma phagocytophilum. A. phagocytophilum causes macrophage activation and hemophagocytic syndrome features. The effect of sialostatin L2 in macrophages was not due to direct caspase-1 enzymatic inhibition, and it did not rely on nuclear factor κB or cathepsin L signaling. Reactive oxygen species from NADPH oxidase and the Loop2 domain of sialostatin L2 were important for the regulatory process. Altogether, our data expand the knowledge of immunoregulatory pathways of tick salivary proteins and unveil an important finding in inflammasome biology.
Quantitative Analysis of Ellipsoid Zone in Acute Posterior Multifocal Placoid Pigment Epitheliopathy (2020)

Purpose: Quantitative end points for uveitis are needed. Here we quantify the rate of ellipsoid zone (EZ) recovery on optical coherence tomography (OCT) and correlate it with visual acuity (VA) improvement in patients with acute posterior multifocal placoid pigmented epitheliopathy (APMPPE). We use automated and manually graded EZ area analysis to assess EZ recovery in APMPPE. Methods: We performed a retrospective review of 9 APMPPE cases (18 eyes) that had characteristic clinical examination and fluorescein angiography findings, outer retinal disruption on spectral-domain OCT, and treatment with systemic steroids after an unambiguous laboratory workup. The EZ was delineated using custom software to perform automated analysis and manual grading by 2 independent physicians. Quantitation of EZ changes was performed in ImageJ (National Institutes of Health). EZ maps were compared with equivalent findings from EZ en face OCT segmentation. Results: The 9 cases in our study were followed for an average of 198 days. Symptomatic improvement occurred in all eyes. VA recovery occurred in 83% of eyes and depended on presenting foveal involvement. Positive slopes of EZ area over time demonstrated recovery. EZ recovery profiles determined by manual and automated software demonstrated high Pearson correlation coefficients (0.78-0.94). Slab en face EZ analysis demonstrated moderate agreement. Conclusions: EZ recovery correlates with symptomatic and VA recovery. Automated EZ analysis shows strong agreement with manually graded EZ analysis in APMPPE. EZ recovery in patients with APMPPE provides a biomarker for recovery and may be applied to other diseases affecting the outer retina.
Lack of lymphatic vessel phenotype in LYVE‐1/CD44 double knockout mice (2009)

Lymphatic vessels play a key role in maintaining tissue-fluid homeostasis, immune surveillance and metastasis. The hyaluronan receptor, LYVE-1, is widely used as a molecular marker for adult and embryonic lymphatic endothelium, but its physiological functions have not yet been established in vivo. In agreement with a recent report, LYVE-1(-/-) mice, which are healthy and fertile, do not display any defects related to congenital abnormalities of the lymphatic system. One hypothesis for the absence of a phenotype in LYVE-1 null mice is that other hyaluronan receptors, such as CD44, may compensate for LYVE-1. To test this hypothesis, we created LYVE-1/CD44 double knockout mice with appropriate littermate controls. Lymphatic vessel structure and function, as determined by histological methods and intravital microscopy, show that LYVE-1(-/-), CD44(-/-) and LYVE-1(-/-)/CD44(-/-) mice are indistinguishable from wild-type mice under normal conditions. Furthermore, resolution of carrageenan-induced paw edema is comparable in all genotypes. However, LYVE-1(-/-)/CD44(-/-) mice exhibit increased edema formation in a carrageenan-induced paw inflammation model compared to wild-type mice, but not to LYVE(-/-) or CD44(-/-) mice. These data suggest that LYVE-1 and CD44 are not required for the formation or function of lymphatics, but do not rule out a role for LYVE-1 in inflammation.