gebhart/patrepeval huggingface dataset:
High Density Heat-Assisted Magnetic Recording Media and Advanced Characterization—Progress and Challenges (2015)

Heat-assisted magnetic recording (HAMR) is being developed as the next generation magnetic recording technology. Critical components of this technology, such as plasmonic near-field transducer (NFT) and high anisotropy granular FePt media, as well as the performance and reliability of fully integrated drives have been reported. This paper will focus on the progress and challenges of HAMR media, including microstructure and thermal design as well as the testing and characterization at high field and high temperature. Due to the importance of the Curie temperature distribution, σT <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">C</sub> , for HAMR, we present a newly developed temperature-dependent complex ac susceptibility method to extract σT <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">C</sub> for HAMR media. Such novel magnetic characterization methods have been used in combination with other high field magnetic metrology and spin-stand recording to provide feedback for continuous improvements of HAMR media. Together with NFT and write head design, the thermal design, σT <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">C</sub> , and microstructure of the media are key factors to reduce the transition jitter below 2 nm as demonstrated in a previously reported 1 Tb/in <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> HAMR demonstration. Here, we report the further improvements by significantly enabling higher linear density (>2500 kfci) HAMR and steady progress in areal density to 1.402 Tb/in <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Copolymerization of 1,2-Epoxycyclohexane and Carbon Dioxide Using Carbon Dioxide as Both Reactant and Solvent (1997)

The copolymerization of 1,2-epoxycyclohexane (cyclohexene oxide, CHO) and carbon dioxide was performed using no other solvent than carbon dioxide itself. A CO2-soluble, ZnO-based catalyst was synthesized and used to catalyze the polymerization. Polymerizations were conducted at different temperatures, pressures, and mole fractions of CHO giving rise to polymer yields as high as 69% with catalyst activities as high as 400 g of polymer/g of Zn. The best results were obtained at temperatures of 100−110 °C and at mole fractions of CHO above XCHO = 0.15. This polymer was >90% polycarbonate with weight average molecular weights (Mw) ranging from 50 000 to 180 000.
Loopback Signal Cancellation Scheme in the Equalization Digital On-Channel Repeater (2007)

We analyze the effect of the loopback signal on the equalization digital on-channel repeater (EDOCR) used for single frequency network (SFN), and propose a simple loopback canceller. Simulation results show that the proposed loopback canceller improves the convergence performance of the decision feedback equalizer (DFE) in the EDOCR by eliminating the loopback signal in advance instead of the DFE.
Halbzeugentwicklung und Strukturfixierung (2013)

Berthel, Andreas; Cherif, Chokri; Diestel, Olaf; Girdauskaite, Lina; Gries, Thomas; Helbig, Reinhard; Hübner, Matthias; Klingele, Josef; Krzywinski, Sybille; Küppers, Simon; Planck, Heinrich; Thielemann, Günther; Weser, Thomas
Lumen-Apposing Covered Self-Expanding Metal Stent for Management of Benign Gastrointestinal Strictures (2015)

Introduction: Self-expanding metal stents (SEMS) are safe and effective for endoscopic management of malignant gastrointestinal strictures. There is limited experience with the use of SEMS in the management of refractory benign gastrointestinal strictures. In benign strictures SEMS placement is associated with higher risk of adverse events compared to dilation therapy alone. In this report we describe the use of a new lumen-apposing covered SEMS (Axios; Xlumena, Mountain View, CA) for the management of benign gastrointestinal strictures and discuss some of the inherent advantages of this novel approach. Methods: Single-center case-series of five patients who underwent lumen-apposing covered SEMS placement for benign gastrointestinal strictures. Results: Four patients had a benign gastroduodenal stricture and one patient had a distal colonic anastomotic stricture. All patients tolerated the procedure well. None of the patients developed any immediate or delayed stent-related adverse events. In two patients the stents were left in place indefinitely. Stent removal was achieved endoscopically in the other 3 patients with successful clinical resolution of their symptoms. Conclusion: This study describes the feasibility and effective use of a novel stent for the management of select benign gastrointestinal strictures.Figure 1Figure 2
Solid electrolyte technology with rearrangeable bonds for metal and metal-ion batteries (2023)

In an embodiment, a metal or metal-ion battery cell, includes anode and cathode electrodes, a separator electrically separating the anode and the cathode, and a solid electrolyte ionically coupling the anode and the cathode, wherein the solid electrolyte comprises a material having one or more rearrangeable chalcogen-metal-hydrogen groups that are configured to transport at least one metal-ion or metal-ion mixture through the solid electrolyte, wherein the solid electrolyte exhibits a melting point below about 350° C. In an example, the solid electrolyte may be produced by mixing different dry metal-ion compositions together, arranging the mixture inside of a mold, and heating the mixture while arranged inside of the mold at least to a melting point (e.g., below about 350° C.) of the mixture so as to produce a material comprising one or more rearrangeable chalcogen-metal-hydrogen groups.
[(1S,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphine (2009)

[43077-29-8] C22H29P (MW 324.44)

InChI = 1S/C22H29P/c1-17(2)21-15-14-18(3)16-22(21)23(19-10-6-4-7-11-19)20-12-8-5-9-13-20/h4-13,17-18,21-22H,14-16H2,1-3H3/t18-,21+,22+/m1/s1

InChIKey = BEYDOEXXFGNVRZ-COPCDDAFSA-N


Phosphine, [(1R,2R,5S)-5-methyl-2-(1-methylethyl)cyclohexyl]diphenyl-, rel-[32511-22-1]

InChI = 1S/C22H29P/c1-17(2)21-15-14-18(3)16-22(21)23(19-10-6-4-7-11-19)20-12-8-5-9-13-20/h4-13,17-18,21-22H,14-16H2,1-3H3/t18-,21+,22+/m0/s1

InChIKey = BEYDOEXXFGNVRZ-VLCRHTCISA-N


Phosphine, [(1R,2R,5S)-5-methyl-2-(1-methylethyl)cyclohexyl]diphenyl-[38053-73-5]

InChI = 1S/C22H29P/c1-17(2)21-15-14-18(3)16-22(21)23(19-10-6-4-7-11-19)20-12-8-5-9-13-20/h4-13,17-18,21-22H,14-16H2,1-3H3/t18-,21+,22+/m0/s1

InChIKey = BEYDOEXXFGNVRZ-VLCRHTCISA-N


Phosphine, [(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]diphenyl-[43077-31-2]

InChI = 1S/C22H29P/c1-17(2)21-15-14-18(3)16-22(21)23(19-10-6-4-7-11-19)20-12-8-5-9-13-20/h4-13,17-18,21-22H,14-16H2,1-3H3/t18-,21+,22-/m1/s1

InChIKey = BEYDOEXXFGNVRZ-BVYCBKJFSA-N







(chiral monodentate phosphine ligand for asymmetric catalysis, resolution of organometallic complexes)



Alternative Names: (+)-(S)-NMDPP; (+)-NMDPP; (+)-neomenthyldiphenylphosphine; (S)-neomenthyldiphenylphosphine; diphenyl-(+)-neomenthylphosphine; neomenthyldiphenylphosphine; d-neomenthyldiphenylphosphine.



Physical Data: mp 98–99 °C; white crystalline solid.



Solubility: soluble in EtOAc, THF, DMI, benzene, DCM, and CHCl3; slightly soluble in MeOH and EtOH.



Form Supplied in: only the dextrorotatory antipode, (+)-NMDPP, is commercially available in variable levels of purity.



Analysis of Reagent Purity: NMDPP oxide is a tenacious impurity and is assayed by 31P NMR (300 MHz, THF) δ: 33 (NMDPP oxide), −14.9 (NMDPP).



Preparative Methods: NMDPP is prepared by the formation of diphenylphosphide from diphenylphosphine,1 diphenylphosphinous chloride,2 or triphenylphosphine,3 followed by alkylation with menthyl chloride or mesylate. (−)-Menthyldiphenylphosphine ((−)-MDPP), an epimer of (+)-NMDPP at C-1 of the menthyl ring, is prepared similarly by the displacement of neomenthylchloride with diphenylphosphide1a or, alternatively, by the displacement of diphenylphosphinous chloride with the Grignard reagent derived from menthyl chloride.4



Purification: recrystallized from MeOH or EtOH at reflux (degassed with N2) with rigorous exclusion of oxygen.



Handling, Storage, and Precautions: oxygen must be excluded to avoid formation of the phosphine oxide; reagent is stable for extended periods when stored in a glovebox.
SBPOR: Second-Order Balanced Truncation for Passive Order Reduction of RLC Circuits (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Fabrication of Multiple Slanted Microstructures on Silica Glass by Laser-Induced Backside Wet Etching (2010)

Slanted microstructures were fabricated on silica glass by laser-induced backside wet etching (LIBWE) with gradual shift of the area irradiated by normal incidence. Slanted microtrenches with tilting angles up to about 30 degrees could be fabricated by lateral shift of the irradiated area with the speed of ~5.0 nmpulse -1 under the conditions showing the vertical etching with rate of 7.0 -11 nmpulse -1 . Tilting angle could be controlled by the speed of lateral shift the irradiated area during the etching. Such structures were formed as a result of both lateral and vertical etching at the etch front. The trench structure fabricated by drastic shift of the irradiated area indicated that the etching of the sidewalls occurred at the area with height of around 400 nm.
Lung spatial profiling reveals a T cell signature in COPD patients with fatal SARS-CoV-2 infection (2022)

Abstract Rationale People with pre-existing lung diseases like chronic obstructive pulmonary disease (COPD) are more likely to get very sick from SARS-CoV-2 disease 2019 (COVID-19), but an interrogation of the immune response to COVID-19 infection, spatial throughout the lung structure is lacking in patients with COPD. Objectives To profile the immune microenvironment of lung parenchyma, airways, and vessels of never- and ever-smokers with or without COPD, whom all died of COVID-19, using spatial transcriptomic and proteomic profiling. Findings The parenchyma, airways, and vessels of COPD patients, compared to control lungs had: 1) significant enrichment for lung resident CD45RO + memory T cells; 2) downregulation of genes associated with T cell antigen-priming and memory T cell differentiation; 3) higher expression of proteins associated with SARS-CoV-2 entry and major receptor ubiquitously across the ROIs and in particular the lung parenchyma, despite similar SARS-CoV-2 structural gene expression levels. Conclusions The lung parenchyma, airways, and vessels of COPD patients have increased T-lymphocytes with a blunted memory T cell response and a more invasive SARS-CoV-2 infection pattern, and may underlie the higher death toll observed with COVID-19.
Fluorescence Fingerprint of Waters: Excitation-Emission Matrix Spectroscopy as a Tracking Tool (2000)

In this report, an optical method for tracking sources of water entering rivers and oceans is applied to the Congaree River in Columbia, South Carolina. The Congaree River forms at the confluence of two rivers, the Saluda and the Broad. Excitation-emission matrix (EEM) spectra of water samples from the rivers were constructed by scanning emission spectra from 300 to 600 nm as a function of excitation wavelength from 200 to 290 nm. The two sources of water in the Congaree River were easily distinguishable on the basis of the EEM spectra of the water samples. In addition, the average composition of water in the Congaree River and hence the relative flow rates of inflowing Saluda and Broad Rivers could be determined. In this report, the characteristic fluorescence of the river water samples and the stability of the EEM spectra of the river samples over several months are presented.
Identification of a Chemosensory Receptor from the Yellow Fever Mosquito, Aedes aegypti, that is Highly Conserved and Expressed in Olfactory and Gustatory Organs (2004)

Aedes aegypti is a highly anthropophilic mosquito responsible for the transmission of dengue and yellow fever around the world. Like other mosquitoes, the biting and host preference behaviors of this disease vector are largely influenced by its sense of smell, which is presumably facilitated by G protein-coupled receptor signaling cascades. Here, we report the identification and characterization of AaOr7, the first candidate odorant receptor from Ae. aegypti. This receptor displays extremely high primary amino acid conservation with AgOr7 another candidate odorant receptor identified in the Aftrotropical malaria vector, Anopheles gambiae as well as several previously identified candidate odorant receptors in Drosophila melanogaster and other insects. Its transcript is expressed in adult chemosensory tissues and during several stages of Ae. aegypti development. Within the adult olfactory system, AaOr7 protein is found specifically within most antennal and maxillary palp sensilla, as well as in a subset of proboscis sensilla. These results are consistent with a role for AaOr7 in olfaction and gustation supporting the hypothesis that AaOr7 and its orthologs may be of general importance to chemosensory processes throughout the lifetime of an insect.
Identification and characterization of a chromosomal virulence gene, vacJ, required for intercellular spreading of Shigella flexneri (1994)

Intercellular spreading of shigellae is a prerequisite for shigellosis, although the molecular mechanisms underlying the phenomenon are still largely obscure. To elucidate some of these mechanisms, we performed random Tn10 insertion mutagenesis in Shigella flexneri YSH6000T and found a chromosomal locus in the NotI-J segment responsible for bacterial spreading. The locus affected in the mutant, designated vacJ, was neither involved in the invasion of epithelial cells nor in intracellular movement, but was required for intercellular spread. The vacJ mutant was capable of forming bacterium-containing membranous protrusions within the infected cell, but had diminished ability to move from the protrusions into the cytoplasm of the adjacent epithelial cells. Cloning and sequencing of the vacJ region indicated that the vacJ gene encoded a 28.0 kDa protein possessing a signal peptide at the N-terminus, which contained the motif characteristic of lipoproteins. The analysis of the vacJ product indicated that VacJ was exposed on the bacterial surface. The vacJ gene was distributed among shigellae and enteroinvasive Escherichia coli, and the constructed vacJ mutants failed to spread intercellularly, indicating that vacJ is a chromosomal gene essential for the pathogenicity of shigellae.
Surface-functionalization with NFL peptide of Ferrocifen loaded Lipid NanoCapsules: preferential entry into human glioblastoma cells (2019)

International audience
Metastable Defects in Proton Implanted and Annealed Silicon (2015)

Two metastable defects with energy levels at Ec-0.28eV and Ec-0.37eV, which previously have been reported in proton implanted- and in proton implanted and annealed crystalline silicon are discussed. Recent results on the peculiar behavior of these defects upon periodical application of two different bias conditions during DLTS measurement are reviewed. Two specifically designed DLTS measurement sequences are proposed in order to further reveal the defects transformation rates and respective activation energies.
Role of p53 in the inhibitory effects of interferon-α subtypes on proliferation of hepatocellular carcinoma cells (2006)

While interferon-alpha (IFN-alpha) subtypes share a common specific receptor composed of two subunits, interferon-alpha receptor (IFNAR)-1 and IFNAR-2, their subtype activities are exhibited via several intracellular signaling pathways and thus subsequently show different biological effects. Anti-proliferative effects of single treatment with IFN-alpha subtypes or 5-fluorouracil (FU), and of combined treatment with each IFN-alpha subtype and 5-FU were examined on three hepatocellular carcinoma cell lines, HepG2, HLE and PLC/PRF/5. HepG2 and PLC/PRF/5 cells were susceptible to the combination treatment, but HLE cells were not. Proliferation of PLC/PRF/5 cells was also inhibited by the IFN-alpha subtypes singly. In addition, apoptosis was observed in HepG2 cells upon treatment with 5-FU alone and with the combination treatment, and in PLC/PRF/5 cells after single treatment with the IFN-alpha subtypes and after the combination treatment. IFN-alpha subtypes induced cell cycle arrest in the G2/M phase in HepG2 and PLC/PRF/5. Analyses by Western blotting and immunoprecipitation revealed increased p53 phosphorylation in HepG2 and PLC/PRF/5 cells but not in HLE cells after combined treatment. Single treatment with IFN-alpha subtypes promoted p53 activation only in PLC/PRF/5 cells. These results propose that IFN-alpha subtypes induce cells to undergo apoptosis through p53 activation directly and indirectly, in collaboration with 5-FU, further suggesting the presence of distinct signal pathways for IFN-alpha-induced apoptosis.
The characterization of amphibian nucleoplasmins yields new insight into their role in sperm chromatin remodeling (2006)

We have shown that these organisms, in striking contrast to their SNBPs, all contain nucleoplasmins with very similar primary structures. This result has important implications as it suggests that nucleoplasmin's role in chromatin assembly during early zygote development could have been complemented by the acquisition of a new function of non-specifically removing SNBPs in sperm chromatin remodeling. This acquired function would have been strongly determined by the constraints imposed by the appearance and differentiation of SNBPs in the sperm.
Assessing N-use efficiency, planting time and economics of fertilizer N in rose-scented geranium (Pelargonium graveolens L Herit)in Western Himalayan Region of India (2011)

A field experiment was conducted to study the effect of N levels and planting times on growth, biomass and oil yield attributes, agronomic efficiency (AE) and partial factor productivity (PFP), and economics of N application through marginal analysis. Results indicated that reducing the duration (from planting to harvesting) from December (144 days) to April (74 days) significant result in reduction in percent dry matter production, biomass, oil yield, PFP, AE and net income. Nitrogen application significantly increased dry matter production, leaf/stem ratio, biomass and oil yield in February planted crop. The AE of applied N, were also higher in February planted crop. The AE of applied nitrogen at 50, 100 and 150 kg N ha-1 were 188, 224 and 200 kg-1 kg N respectively. At 100 kg N ha-1 the crop earned a maximum profit Rs. 30.02. The quality of essential oil was not significantly influenced by application of different nitrogen levels.

	 

	Key words: Nitrogen, fertilizer, agronomic efficiency, scented geranium.
Antigenic Characteristics and Genome Composition of a Naturally Occurring Recombinant Influenza Virus Isolated from a Pig in Japan (1983)

We performed antigenic analysis of the haemagglutinin and neuraminidase subunits of a recombinant virus (A/swine/Kanagawa/2/78) isolated from a pig in Japan in 1978, using a series of monoclonal antibodies to H1 (Hsw1) haemagglutinin and N2 neuraminidases of H2N2 and H3N2 viruses. Results obtained in haemagglutination inhibition tests with five monoclonal antibodies to the haemagglutinin of A/NJ/8/76 (H1N1) revealed that the haemagglutinin of three H1N1 and the recombinant viruses were indistinguishable from that of A/NJ/8/76. The neuraminidase of A/swine/Kanagawa/2/78 was found to be antigenically similar to A/Kumamoto/22/76 (H3N2, A/Victoria/3/75-like strain). The oligonucleotide maps of the entire RNAs of H1N1, H1N2 and H3N2 viruses showed that A/swine/Kanagawa/2/78 (H1N2) virus was more similar to swine (H1N1) virus than to A/Kumamoto/22/76 (H3N2) virus. Radioactive cDNA was prepared by reverse transcription of the recombinant virus RNA using a dodecadeoxyribonucleotide primer and used in DNA-RNA hybridization experiments. The results obtained in molecular hybridization based on blotting procedures showed that all cDNA segments except gene 6 hybridized efficiently with RNAs of swine (H1N1) influenza virus. The sixth cDNA segment was homologous to the corresponding RNA segment of H3N2 virus. The genetic relatedness of A/swine/Kanagawa/2/78 (H1N2) with either A/swine/Kanagawa/4/78 (H1N1) or A/Kumamoto/22/76 (H3N2) was clearly established by hybridization between the cDNA segment probes and viral RNA. It was concluded that the neuraminidase gene of A/swine/Kanagawa/2/78 (H1N2) was derived from a human H3N2 virus, while the seven other genes were from a swine H1N1 virus.
Probabilistic Aggregated Load Forecasting with Fine-grained Smart Meter Data (2021)

Probabilistic load forecasting (PLF) has been extensively studied to characterize the uncertainties of future loads. Traditional PLF is implemented based on the historical load data itself and other relevant factors. However, the prevalence of smart meters provides more fine-grained consumption information. This paper proposes a novel probabilistic aggregated load forecasting algorithm that makes full use of fine-grained smart meter data. It first applies clustering-based methods for point aggregated load forecasting. By varying clustering algorithms, multiple point forecasts can be obtained. On this basis, different quantile regression models are implemented to combine these point forecasts in order to form the final probabilistic forecasts. Case studies on a real-world dataset demonstrate the superiority of our proposed method.
Ex vivo biomechanical properties of the female urethra in a rat model of birth trauma (2006)

Stress urinary incontinence (SUI) is the involuntary release of urine during sudden increases in abdominal pressures. SUI is common in women after vaginal delivery or pelvic trauma and may alter the biomechanical properties of the urethra. Thus we hypothesize that injury due to vaginal distension (VD) decreases urethral basal tone and passive stiffness. This study aimed to assess the biomechanical properties of the urethra after VD in the baseline state, where basal muscle tone and extracellular matrix (ECM) are present, and in the passive state, where inactive muscle and ECM are present. Female rat urethras were isolated in a rat model of acute SUI induced by simulated birth trauma. Our established ex vivo system was utilized, wherein we applied intraluminal static pressures ranging from 0 to 20 mmHg. Outer diameter was measured via a laser micrometer. Measurements were recorded via computer. Urethral thickness was assessed histologically. Stress-strain responses of the urethra were altered by VD. Quantification of biomechanical parameters indicated that VD decreased baseline stiffness. The passive peak incremental elastic modulus of the distal segment in VD urethras was less than for controls (1.84 +/- 0.67 vs. 1.19 +/- 0.70 x 10(6) dyne/cm(2), respectively; P = 0.016). An increase was noted in passive low-pressure compliance values in proximal VD urethras compared with controls (9.44 +/- 2.43 vs. 4.62 +/- 0.60 mmHg(-1), respectively; P = 0.04). Biomechanical analyses suggest that VD alters urethral basal tone, proximal urethral compliance, and distal stiffness. Lack of basal smooth muscle tone, in combination with these changes in the proximal and distal urethra, may contribute to SUI induced by VD.