gebhart/patrepeval huggingface dataset:
On the Regioselectivity of Photocycloadditions of Triplet Cyclohexenones to Alkenes (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOn the Regioselectivity of Photocycloadditions of Triplet Cyclohexenones to AlkenesJeffrey L. Broeker, John E. Eksterowicz, Anna J. Belk, and K. N. HoukCite this: J. Am. Chem. Soc. 1995, 117, 6, 1847–1848Publication Date (Print):February 1, 1995Publication History Published online1 May 2002Published inissue 1 February 1995https://doi.org/10.1021/ja00111a030RIGHTS & PERMISSIONSArticle Views301Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (926 KB) Get e-Alerts Get e-Alerts
Identification and characterization of peptidoglycan-associated proteins in Neisseria gonorrhoeae (1989)

The principal proteins associated with Neisseria gonorrhoeae peptidoglycan (PG), as identified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, are the following: two proteins at approximately 90 kilodaltons (kDa), single major species at both 60 and 44 kDa, a 34- to 36-kDa protein, and three proteins between 28 and 32 kDa. A protein analogous to Escherichia coli Braun lipoprotein was not detected with gonococcal cell wall preparations. The identity of the PG-associated proteins was confirmed immunologically with antibody generated against purified cell walls. Two types of protein species, dithiothreitol extractable (the majority) and alkylation dependent (primarily the 34- to 36-kDa protein), appeared to be associated with the N. gonorrhoeae cell wall fraction. It was found that a crucial step in the extraction of the proteins from the PG fraction was the inclusion of an acetone-water wash of the purified PG pellet. Studies with cell wall preparations obtained from N. gonorrhoeae intrinsically labeled with 32P revealed that the acetone wash was removing phospholipid from the cell wall fraction and thus facilitating protein extraction. Autoradiographic analysis with PG material derived from 125I-surface-labeled cells indicated that the 44-kDa protein is exposed on the surface of the organism even when associated with the PG layer. Radioimmunoprecipitation with anti-PG antibody confirmed these findings. Lectin analysis (wheat germ agglutinin conjugated to horseradish peroxidase) suggested that the 34- to 36-kDa protein is covalently attached to the PG layer.
Energy-efficient variable-flow liquid cooling in 3D stacked architectures (2010)

Liquid cooling has emerged as a promising solution for addressing the elevated temperatures in 3D stacked architectures. In this work, we first propose a framework for detailed thermal modeling of the microchannels embedded between the tiers of the 3D system. In multicore systems, workload varies at runtime, and the system is generally not fully utilized. Thus, it is not energy-efficient to adjust the coolant flow rate based on the worst-case conditions, as this would cause an excess in pump power. For energy-efficient cooling, we propose a novel controller to adjust the liquid flow rate to meet the desired temperature and to minimize pump energy consumption. Our technique also includes a job scheduler, which balances the temperature across the system to maximize cooling efficiency and to improve reliability. Our method guarantees operating below the target temperature while reducing the cooling energy by up to 30%, and the overall energy by up to 12% in comparison to using the highest coolant flow rate.
Targeted disruption of the Hexa gene results in mice with biochemical and pathologic features of Tay-Sachs disease. (1994)

Tay-Sachs disease, the prototype of the GM2 gangliosidoses, is a catastrophic neurodegenerative disorder of infancy. The disease is caused by mutations in the HEXA gene resulting in an absence of the lysosomal enzyme, beta-hexosaminidase A. As a consequence of the enzyme deficiency, GM2 ganglioside accumulates progressively, beginning early in fetal life, to excessive amounts in the central nervous system. Rapid mental and motor deterioration starting in the first year of life leads to death by 2-4 years of age. Through the targeted disruption of the mouse Hexa gene in embryonic stem cells, we have produced mice with biochemical and neuropathologic features of Tay-Sachs disease. The mutant mice displayed < 1% of normal beta-hexosaminidase A activity and accumulated GM2 ganglioside in their central nervous system in an age-dependent manner. The accumulated ganglioside was stored in neurons as membranous cytoplasmic bodies characteristically found in the neurons of Tay-Sachs disease patients. At 3-5 months of age, the mutant mice showed no apparent defects in motor or memory function. These beta-hexosaminidase A-deficient mice should be useful for devising strategies to introduce functional enzyme and genes into the central nervous system. This model may also be valuable for studying the biochemical and pathologic changes occurring during the course of the disease.
Improvement of write/erase cycling of memory cells with SiO/sub 2//HfO/sub 2/ tunnel dielectric (2004)

The write/erase endurance of low voltage floating gate memory cells programmed and eased by tunneling through a SiO/sub 2//HfO/sub 2/ dual layer tunnel dielectric stack is investigated. The used of fixed single pulse program and erase conditions lead to fast shifting (after /spl sim/1000 cycles) of the threshold voltage window, so that only a limited number of write/erase cycles can be achieved. Increasing the write and erase duration quickly leads to an excessive erase time so that a different erase method has to be used while the duration remains almost constant. Improvement of the erase behavior and cycling endurance has been obtained by a combination of two methods: inclusion of soft write pulses between the write pulses reduces the amount of charge trapped in the tunneling dielectric and therefore limits the increase in erase time, leading to an endurance of 10,000 cycles on the considered cells. A capacitor level pseudo cell setup has been used to perform write-only cycling up to 100,000 cycles indicating that the endurance of SiO/sub 2//HfO/sub 2/ stacks can be obtained if current transport is only required in one direction, for example when using this stack for interpoly erasing of memory cells programmed by channel hot electron injection.
Low-modulus PMMA bone cement modified with castor oil (2011)

Some of the current clinical and biomechanical data suggest that vertebroplasty causes the development of adjacent vertebral fractures shortly after augmentation. These findings have been attributed to high injection volumes as well as high Young's moduli of PMMA bone cements compared to that of the osteoporotic cancellous bone. The aim of this study was to evaluate the use of castor oil as a plasticizer for PMMA bone cements. The Young's modulus, yield strength, maximum polymerization temperature, doughing time, setting time and the complex viscosity curves during curing, were determined. The cytotoxicity of the materials extracts was assessed on cells of an osteoblast-like cell line. The addition of up to 12 wt% castor oil decreased yield strength from 88 to 15 MPa, Young's modulus from 1500 to 446 MPa and maximum polymerization temperature from 41.3 to 25.6°C, without affecting the setting time. However, castor oil seemed to interfere with the polymerization reaction, giving a negative effect on cell viability in a worst-case scenario.
Predictors of Free Flap Volume Loss in Nonosseous Reconstruction of Head and Neck Oncologic Defects (2020)

Our model predicts percent free flap volume loss in a significant fashion. Age and RF are individual predictors of free flap volume loss, the latter being a novel finding that is also modifiable through hyperfractionation radiotherapy schedules.
Mechanism of k-value Reduction of PECVD Low-k Films Treated with He/H2 Ash Plasma (2010)

The over-ash effect of He/H2 downstream plasma on various low-k materials (k = 2.3 – 2.5) is studied. The results show reduced k-value for PECVD materials. The k-value reduction mechanism of PECVD low-k materials is found to be a result of two competing phenomena: porosity increase (due to porogen residue removal) results in k-value reduction while minor silanol group incorporation results in k-value increase. Furthermore, it is shown that the k-value of the PECVD films with a lower porogen loading (k~2.5) can be reduced by the He/H2-DSP over-ash without a degradation of their mechanical properties.
Glossary of Methods and Terms Used in Surface Chemical Analysis (IUPAC Recommendations 2020) (2021)

This glossary provides a formal vocabulary of terms for concepts in surface analysis and gives clear definitions to those who utilize surface chemical analysis or need to interpret surface chemical analysis results but are not themselves surface chemists or surface spectroscopists.
Recursive MIS Computation for Streaming BDPT on the GPU (2012)

Abstract—Bidirectional Path Tracing (BDPT) is a robust unbiased rendering algorithm that samples paths by connecting eye and light paths. By optimally combining different sampling strategies using Multiple Importance Sampling (MIS), BDPT efficiently renders scenes with complex light effects. However, BDPT does not map well on a streaming architecture such as the GPU; Stochastic path lengths lead to an uneven workload between BDPT samples and a large memory footprint that depends on the maximum allowed path length. In this paper, we present a streaming alternative to BDPT, called SBDPT. We present a novel scheme for recursively computing balance heuristic MIS weights. This scheme allows for bidirectional connections to be evaluated independently, only requiring data from the light and eye vertex directly involved in the connection. Using this property, we modify the BDPT algorithm to generate a new eye path for each light vertex. The resulting SBDPT algorithm only requires temporary storage for the last vertex on both eye and light paths. Our implementation achieves high performance and has a fixed low memory footprint, independent of the maximum path length. 1
Computational proteomics analysis of HIV‐1 protease interactome (2007)

HIV-1 protease is a small homodimeric enzyme that ensures maturation of HIV virions by cleaving the viral precursor Gag and Gag-Pol polyproteins into structural and functional elements. The cleavage sites in the viral polyproteins share neither sequence homology nor binding motif and the specificity of the HIV-1 protease is therefore only partially understood. Using an extensive data set collected from 16 years of HIV proteome research we have here created a general and predictive rule-based model for HIV-1 protease specificity based on rough sets. We demonstrate that HIV-1 protease specificity is much more complex than previously anticipated, which cannot be defined based solely on the amino acids at the substrate's scissile bond or by any other single substrate amino acid position only. Our results show that the combination of at least three particular amino acids is needed in the substrate for a cleavage event to occur. Only by combining and analyzing massive amounts of HIV proteome data it was possible to discover these novel and general patterns of physico-chemical substrate cleavage determinants. Our study is an example how computational biology methods can advance the understanding of the viral interactomes.
The combined use of paclitaxel-loaded nanoparticles with a low-molecular-weight copolymer inhibitor of P-glycoprotein to overcome drug resistance (2013)

Two types of nanoparticles were prepared using the diblock copolymer methoxy poly(ethylene glycol)-block-poly(caprolactone) (MePEG-b-PCL), with either a short PCL block length, which forms micelles, or with a longer PCL block length, which forms kinetically "frozen core" structures termed nanospheres. Paclitaxel (PTX)-loaded micelles and nanospheres were evaluated for their cytotoxicity, cellular polymer uptake, and drug accumulation in drug-sensitive (Madin-Darby Canine Kidney [MDCK]II) and multidrug-resistant (MDR) P-glycoprotein (P-gp)-overexpressing (MDCKII-MDR1) cell lines. Both types of PTX-loaded nanoparticles were equally effective at inhibiting proliferation of MDCKII cells, but PTX-loaded micelles were more cytotoxic than nanospheres in MDCKII-MDR1 cells. The intracellular accumulation of both PTX and the diblock copolymers were similar for both nanoparticles, suggesting that the difference in cytotoxicity might be due to the different drug-release profiles. Furthermore, the cytotoxicity of these PTX-loaded nanoparticles was enhanced when these systems were subsequently or concurrently combined with a low-molecular-weight MePEG-b-PCL diblock copolymer, which we have previously demonstrated to be an effective P-gp inhibitor. These results suggest that the dual functionality of MePEG-b-PCL might be useful in delivering drug intracellularly and in modulating P-gp in order to optimize the cytotoxicity of PTX in multidrug-resistant cells.
The kinetics of water sorption in Nafion membranes: a small-angle neutron scattering study (2011)

The optimization of the water management in proton exchange membrane fuel cells is a major issue for the large-scale development of this technology. In addition to the operating conditions, the membrane water sorption and transport processes obviously control the water management. The main objective of this work is to provide new experimental evidence based on the use of the small-angle neutron scattering (SANS) technique in order to allow a better understanding of water sorption processes. SANS spectra were recorded for membranes equilibrated with either water vapor or liquid. Sorption kinetics data were determined and the SANS spectra were analyzed using the method developed for extracting water concentration profiles across the membrane in operating fuel cells. The water concentration profiles across the membrane are completely flat, which indicates that the water diffusion within the membrane is not the limiting process. This result provides new insight into the numerous data published on these properties. For the first time, the swelling kinetics of a Nafion membrane immersed in liquid water is studied and a complete swelling is obtained in less than 1 min.
Biological effect of orbital atherectomy and adjunctive paclitaxel-coated balloon therapy on vascular healing and drug retention: early experimental insights into the familial hypercholesterolaemic swine model of femoral artery stenosis (2014)

In the experimental setting, the combination of OAS+PCB appears to be safe by demonstrating a vascular healing profile and drug tissue levels comparable to PCB only. The vascular effect of PCB may be enhanced by the use of OAS by decreasing plaque burden and cholesterol crystals.
Contribution au développement de l'analyse non séparative d'espaces de tête spectrométrie de masse (2005)

The aim if this research was to contribute to the development of non separative analysis of headspaces by mass spectrometry. Firstly, optimisation of acquisition conditions of spectral fingerprints and pre-processing of the signal were studied. Then, new possibilities were developed : control of significant processes, typology of atmospheres and estimation of sensory characteristics. Lastly, to improve the setting up of perennial databases, the limitations related to the instability of the instrumentation were investigated. A new method of signal correction based on the introduction of an inert gas into the MS made it possible to correct the effect related to the modifications of acquisitions parameters. The obtained results demonstrated that NSA-MS offer powerful potentialities for analytical characterization provided that they would be integrated ina rigorous strategy of fingerprints acquisition and data treatment.
Phosphene perceptions and safety of chronic visual cortex stimulation in a blind subject (2019)

Stimulation of primary visual cortices has the potential to restore some degree of vision to blind individuals. Developing safe and reliable visual cortical prostheses requires assessment of the long-term stability, feasibility, and safety of generating stimulation-evoked perceptions.A NeuroPace responsive neurostimulation system was implanted in a blind individual with an 8-year history of bare light perception, and stimulation-evoked phosphenes were evaluated over 19 months (41 test sessions). Electrical stimulation was delivered via two four-contact subdural electrode strips implanted over the right medial occipital cortex. Current and charge thresholds for eliciting visual perception (phosphenes) were measured, as were the shape, size, location, and intensity of the phosphenes. Adverse events were also assessed.Stimulation of all contacts resulted in phosphene perception. Phosphenes appeared completely or partially in the left hemifield. Stimulation of the electrodes below the calcarine sulcus elicited phosphenes in the superior hemifield and vice versa. Changing the stimulation parameters of frequency, pulse width, and burst duration affected current thresholds for eliciting phosphenes, and increasing the amplitude or frequency of stimulation resulted in brighter perceptions. While stimulation thresholds decreased between an average of 5% and 12% after 19 months, spatial mapping of phosphenes remained consistent over time. Although no serious adverse events were observed, the subject experienced mild headaches and dizziness in three instances, symptoms that did not persist for more than a few hours and for which no clinical intervention was required.Using an off-the-shelf neurostimulator, the authors were able to reliably generate phosphenes in different areas of the visual field over 19 months with no serious adverse events, providing preliminary proof of feasibility and safety to proceed with visual epicortical prosthetic clinical trials. Moreover, they systematically explored the relationship between stimulation parameters and phosphene thresholds and discovered the direct relation of perception thresholds based on primary visual cortex (V1) neuronal population excitation thresholds.
Hexafluoro-2-butyne-metal atom chemistry. Stable complexes, small organometallic clusters, and metal-acetylene telomers (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHexafluoro-2-butyne-metal atom chemistry. Stable complexes, small organometallic clusters, and metal-acetylene telomersKenneth J. Klabunde, Thomas Groshens, Michael Brezinski, and William KennellyCite this: J. Am. Chem. Soc. 1978, 100, 14, 4437–4440Publication Date (Print):July 1, 1978Publication History Published online1 May 2002Published inissue 1 July 1978https://pubs.acs.org/doi/10.1021/ja00482a020https://doi.org/10.1021/ja00482a020research-articleACS PublicationsRequest reuse permissionsArticle Views65Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Characterization of the non-glycosylated protein region of pig gastric muous glycoprotein (1981)

Conference Abstract| April 01 1981 Characterization of the non-glycosylated protein region of pig gastric muous glycoprotein J. P. Pearson; J. P. Pearson 1Department of Physiology, University of Newcastle upon Tyne NE1 7RU, U.K. Search for other works by this author on: This Site PubMed Google Scholar A. Allen A. Allen 1Department of Physiology, University of Newcastle upon Tyne NE1 7RU, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1981) 9 (2): 182P. https://doi.org/10.1042/bst009182pc Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation J. P. Pearson, A. Allen; Characterization of the non-glycosylated protein region of pig gastric muous glycoprotein. Biochem Soc Trans 1 April 1981; 9 (2): 182P. doi: https://doi.org/10.1042/bst009182pc Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1981 Biochemical Society1981 Article PDF first page preview Close Modal You do not currently have access to this content.
3D inkjet printing of tablets exploiting bespoke complex geometries for controlled and tuneable drug release (2017)

A hot melt 3D inkjet printing method with the potential to manufacture formulations in complex and adaptable geometries for the controlled loading and release of medicines is presented. This first use of a precisely controlled solvent free inkjet printing to produce drug loaded solid dosage forms is demonstrated using a naturally derived FDA approved material (beeswax) as the drug carrier and fenofibrate as the drug. Tablets with bespoke geometries (honeycomb architecture) were fabricated. The honeycomb architecture was modified by control of the honeycomb cell size, and hence surface area to enable control of drug release profiles without the need to alter the formulation. Analysis of the formed tablets showed the drug to be evenly distributed within the beeswax at the bulk scale with evidence of some localization at the micron scale. An analytical model utilizing a Fickian description of diffusion was developed to allow the prediction of drug release. A comparison of experimental and predicted drug release data revealed that in addition to surface area, other factors such as the cell diameter in the case of the honeycomb geometry and material wettability must be considered in practical dosage form design. This information when combined with the range of achievable geometries could allow the bespoke production of optimized personalised medicines for a variety of delivery vehicles in addition to tablets, such as medical devices for example.