gebhart/patrepeval huggingface dataset:
Multiple-Cycle Production Data Analysis Using Modern Decline Type Curves (2018)

Summary In the interpretation of production data, challenges arise when the data exhibits “anomalies” caused by events such as recompletions, changes in drive mechanism, long-term shut-ins and unusual fluctuations in flow rate and pressure. The method available in literature for resolving such anomalies when using modern decline type curves (MDTCs), which employ material balance time/pseudotime functions, involves a reinitialization approach which is impractical if past production data are unavailable or of low quality. This study, therefore, examines the reliability of a new approach proposed here to reinitialization for MDTC analysis, in which the time after each shut-in period is reset, and the last estimated average reservoir pressure prior to shut-in, with the corresponding fluid properties, is used as the initial condition for the reinitialized cycle. Here historical cumulative production is not employed in the computation of the material balance time function. The approach is verified using multiple-cycle production data (i.e. series of flowing and shut-in periods) generated from 1-dimensional single-well reservoir simulation models, with particular focus on cases with long term shut-ins. The results demonstrate the practicality and reliability of the proposed simple and efficient approach for the analysis of individual production cycles to reliably estimate reservoir and well productivity parameters.
Synthesis of Carbon Nanosheets and Nitrogen-Doped Carbon Nanosheets from Perylene Derivatives for Supercapacitor Application (2018)

The development of an economical, eco-friendly, and easy method for the production of carbon nanosheets and heteroatom-doped carbon nanosheets has been a challenge for material scientists. In this study, we developed a method for the synthesis of carbon nanosheets (CNS) and nitrogen-doped carbon nanosheets (NCNS) of high quality from organic compounds. We exploited the electrostatic interaction among ionic crystals (NaCl in the present case) and polarized aromatic molecules (3,4,9,10-perylene tetracarboxylic dianhydride (PTCDA) and 3,4,9,10-perylene tetracarboxylic diimide (PTCDI) in this work) to obtain uniform coverage of the latter over the surface of the ionic crystal. This NaCl-PTCDA/PTCDI assembly, on pyrolysis at 700 °C followed by washing with water, yields high-quality CNS and NCNS depending on the aromatic precursor employed. The sheets obtained consist of minimum 2–3 layers (∼2 nm) as observed from atomic force microscopy. The process demonstrated is highly scalable, economical, eco-friendly, nonhazardous, and relatively fast. Moreover, the NCNS derived from PTCDI is applied for energy storage application by fabricating an electrochemical capacitor that exhibits an area normalized capacitance of 23 μF cm–2 in 0.5 M H2SO4, which is the same as that reported for the single-layer nitrogen-doped graphene. Furthermore, an NCNS–carbon black composite is prepared and applied to a high-performance solid-state supercapacitor that exhibited a capacitance of 300 mF cm–2.
IgG2a-producing variants of an IgG2b-producing mouse myeloma cell line. (1978)

12 variant cell lines producing an IgG2a (kappa) immunoglobulin derived via different routes from the IgG2b (kappa) synthesizing MPC 11 were studied. These variants all have the parental MPC 11 idiotype as shown by a radioimmunoassay. A comparison of the variants by charge, peptide maps, and assembly patterns has shown that most of them differ from one another, and some can be grouped. One group consists of three primary variants generated with two mutagenic agents: these three have almost indistinguishable peptide maps. Two other primary variants which arose in a similar fashion differ markedly from each other and from this group. A second group is comprised of the four secondary variants which arose from two short heavy chain producing primary variants. Other secondary variants and the one spontaneously arising variant cannot be grouped. Possible genetic mechanisms such as translocation, expression of previously silent genes and recombination are discussed.
Membrane invasion culture system (MICS). (1984)

New methods for studying the invasive properties of malignant neoplasms are being developed continually. The advantages and disadvantages associated with currently available models have been capitalized upon in the development of a new system that is versatile, reliable, fast, and simple to operate. In order for a tumor cell to metastasize, it must be capable of traversing many complex biological barriers. Because treatment metastatic neoplasms poses many problems for the clinician, the elucidation of the invasion process is of vital importance for the successful treatment of malignant disease. We have developed a system for studying the invasive properties of cells that can be performed accurately with relative ease within a short period of time. This versatile system offers extensive applications for studying invasion properties and parameters. Our model is classified as the Membrane Invasion Culture System.
Discrimination of lymph node metastases using desorption electrospray ionisation-mass spectrometry imaging (2013)

Desorption electrospray ionisation mass spectrometry imaging (DESI-MSI) has been used for the identification of cancer within lymph nodes with accurate spatial distribution in comparison to gold standard matched immuno-histopathological images. The metabolic profile of the cancerous lymph nodes was similar to that of the primary tumour site.
Periodic Finite-State Machines (2007)

Finite state machine (FSM) models are widely used to model the operations of computer systems. Since the basic FSM model is timeless, it is not possible to model within the basic FSM framework system properties that are dependent on the progression of real time, such as the duration of computations or the limited temporal validity of real-time data. To overcome these limitations, efforts have been made to modify the FSM model to include some notion of time. It is the objective of this paper to expand existing work on basic FSMs and timed automata to include the concept of a sparse global time base as a central element of the model. We call such an extended FSM model a periodic finite state machine (PFSM) model. The PFSM model also incorporates the notions of state variables, global time, periodic clock constraints, and time-triggered activities. Thereby, PFSMs enable a concise and intuitive representation of distributed control systems and reduce the gap between a modeled system and its implementation
Highly Improved Reliability of Low Threshold 1.3 μm III/V Quantum Dot Laser Epitaxially Grown on On-axis Si (2018)

InAs quantum dot Fabry-Perot lasers grown on on-axis (001) Si demonstrate record-low continuous-wave threshold current of 4.8 mA as well as excellent device reliability with extrapolated lifetimes more than ten million hours at 35 °C.
Best Papers and Star Service Awards (2020)

The Editorial Board of the IEEE Journal of Emerging and Selected Topics in Power Electronics (JESTPE) owes a depth of gratitude and appreciation to the authors who got their papers published in the 2019 editions. After an intensely competitive review of nominated papers by the members of the Editorial Board and some Associate Editors, it is a pleasure to announce the winners of the best papers among those published in the four issues of JESTPE in 2019.
In Silico Identification of Potential Allosteric Inhibitors of the SARS-CoV-2 Helicase (2020)

The COVID-19 pandemic ravages the globe causing unprecedented health and economic challenges. As the world prospects for a cure, scientists are looking critically at strategic protein targets within the SARS-CoV-2 that have therapeutic significance. One of such targets is the Helicase which is an enzyme that affects all aspects of SARS-CoV-2 RNA metabolism. The aim of this study is to identify small molecules from natural products that have strong binding affinity with and inhibitory activity against an allosteric site (Pocket 26) of SARS-CoV-2 Helicase. Pyrx was used for the in silico molecular docking simulations of SARS-CoV-2 Helicase (QHD43415-12.pdb) against a library of small molecules obtained from edible African plants. Triphenylmethane which had a docking score of -7.4 kcal/mol was chosen as a reference molecule. Virtual screening for oral bioavailability was done based on the molecular descriptors of the compounds as provided by Pubchem. SwissADME, pkCSM, and Molinspiration were used for further screening for molar refractivity, saturation, promiscuity, pharmacokinetic properties, and bioactivity respectively. The Galaxy webserver which uses the GROMACS software was used for the molecular dynamic simulation and analyses. The lead compounds are Gibberellin A12, A20 and A51 obtained from Green peas and the Okra plant. Gibberellin A20 and A51 performed better than the standard. Gibberellin A51 is predicted to show the greatest inhibitory activity against SARS-CoV-2 Helicase. It is recommended that the inhibitory activities of the lead compounds be further investigated.
Characterization of the thermal impact of Cu-Cu bonds achieved using TSVs on hot spot dissipation in 3D stacked ICs (2011)

3D-IC stacking is a promising technique for miniaturization and performance enhancement of electronic systems. The complexity of the interconnect structures, combined with the reduced thermal spreading in the thinned dies used for the stacking and the poorly thermally conductive adhesives adopted for bonding the dies in the stack complicate the modeling of the thermal behavior of 3D ICs. The same amount of energy dissipation will lead to higher temperatures and a more pronounced temperature peak in a stacked die with respect to a single die. Therefore, the thermal behavior in a 3D-IC needs to be studied thoroughly. In this paper, the impact of TSVs and the Cu-Cu bonding on the temperature profile of the top and bottom die of a 3D stack is characterized by using dedicated test chips with integrated thermal heaters and temperature sensors. A specific experimental set-up is conceived and used to evaluate and improve the thermal models for the 3D stacks.
Nanoparticle Heat Transfer and Its Application to Laser Hyperthermia (2007)

Nanoparticles-enabled laser hyperthermia holds a great promise as a new therapeutic treatment for cancer patients. This paper presents some preliminary data on the frequency tenability of nanostructures and on the heat transfer aspect of this process that results from the interaction between high frequency electromagnetic field and nanostructures. Maxwell equations are solved to predict heat generation from the surface plasma resonance excitation of a nano-sized particle or structure by a laser beam. An experimental system has also been setup to validate the concept of heat generation through particle-laser interaction. Results obtained on both model tissues and on mice are consistent with the model predictions. Experiments further show that concentrated local heating can be generated in cancerous cells for a thermal kill.
Supplementary Materials and Methods and Supplementary Figure Legends from Preclinical Efficacy of the Auristatin-Based Antibody–Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors (2023)

&lt;p&gt;Supplementary Materials and Methods and Supplementary Figure Legends&lt;/p&gt;
Simulation of protection layers for air-coupled waveguided ultrasonic phased-arrays (2021)

Waveguided air-coupled ultrasonic phased arrays offer grating-lobe-free beam forming for many applications such as obstacle detection, non-destructive testing, flow metering or tactile feedback. However, for industrial applications, the open output ports of the waveguide can be clogged due to dust, liquids or dirt leading to additional acoustic attenuation. In previous work, we presented the effectiveness of hydrophobic fabrics as a protection layer for acoustic waveguides. In this work, we created a numerical model of the waveguide including the hydrophobic fabric allowing the prediction of the insertion loss (IL). The numerical model uses the boundary element method (BEM) and the finite element method (FEM) in the frequency domain including the waveguide, the hydrophobic fabric and the finite-sized rigid baffle used in the measurements. All walls are assumed as ideal sound hard and the transducers are ideal piston transducers. The specific flow resistivity of the hydrophobic fabric, which is required for the simulation, is analyzed using a 3D-printed flow pipe. The simulations are validated with a calibrated microphone in an anechoic chamber. The IL of the simulations are within the uncertainties of the measurements. In addition, both the measurements and the simulations have no significant influence on the beamforming capabilities.
THE SHORT TERM EFFECTS OF POWERBALANCE AND SHUZIQI BRACELETS ON SPORTING PERFORMANCE (2012)

The main aim of the research was to investigate the short term effects (if any) of the PowerBalance and Shuziqi bracelets in the improvement of speed, strength, balance, power and flexibility, with the overall purpose of examining the usefulness of these aids as legal performance enhancers. Eight male Badminton players (n=8; 19.4±1.3 years; 1.8±0.1m; 70.5±11.8kg) from the Western Division 2C of the British Universities and Colleges Sporting Championships were blinded of the identity of 4 conditions being placed upon them throughout the testing procedure (No bracelet, PowerBalance bracelet, Shuzi bracelet and Placebo bracelet). All Participants completed 60m Sprint, Vertical Jump, Balance, Handgrip Dynamometer and the Sit-and-Reach Tests whilst under the 4 different conditions. Each condition was trialled 3 times of which a mean score was calculated and used for data analysis (SPSS Repeated Measures ANOVA). &#13;\nIn summary, there were no significant differences found between the conditions for the enhancement of speed, strength, balance, power and flexibility (p&gt;0.05). The findings of the present study indicate that the usefulness of both PowerBalance and Shuzi bracelets as physiological ergogenic aid is nil. However, the study concluded that the bracelets can be deemed as Psychological ergogenic aids due to the pseudo effect.
Monolithic Mode-Locked Laser and Optical Amplifier for Regenerative Pulsed Optical Clock Recovery (2007)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> We experimentally demonstrate optical clock recovery using a novel mode-locked laser (MLL) monolithically integrated with an output semiconductor optical amplifier. The laser's mirror placement is determined using lithography, allowing for mode locking and clock recovery at the exact frequency of the design (35.00 GHz), which is easily scalable to 40 GHz or higher. The design is compatible with other photonic integrated circuit components, enabling integrated signal processing with MLLs. The device generates pulses at 35.0-GHz repetition rate with 6-ps pulsewidth, over 12-dB extinction ratio (ER), and 8.3-dBm output power. Among other regenerative capabilities, the device performs optical clock recovery with 50% jitter reduction from a degraded input signal with low ER. </para>
Cyclic Tetramer of a Metalloporphyrin Based on a Quadruple Hydrogen Bond (2006)

[reaction: see text] This paper describes the selective formation of a cyclic tetramer from a readily synthesized metalloporphyrin with two self-complementary quadruple hydrogen-bonding units. The extremely strong quadruple hydrogen-bonding unit, 2-ureido-4[1H]-pyrimidinone, enabled the formation of a stable cyclic tetramer based on a tetraphenylporphyrin derivative over a wide concentration range. This hydrogen-bonded tetramer is a new functional unit for use in a higher-ordered architecture of a supramolecular porphyrin assembly.
ChemInform Abstract: PHOTO‐INDUCED OXIDATION OF CARBONATE IONS BY DUROQUINONE, A PATHWAY OF OXYGEN EVOLUTION FROM WATER BY VISIBLE LIGHT (1977)

Abstract In einer laserphotolytischen Untersuchung wird gezeigt, daß CO 3 2‐ ‐Anionen in wäßrigen Lösungen von Dodecyltrimethylammoniumchloridmizellen in der sehr schnellen Reaktion A (&lt;15 ns) durch Durochinon‐Tripletts (DQ T ) oxidiert werden.
An Improved Matrix Pencil Method based Bearing Fault detection in Three Phase Induction Motor (2020)

This paper presents an improved fault detection criteria for bearing faults in a three phase induction motor using current signature analysis. The motor current is extracted under various conditions of the machine and used for analysis in frequency domain. To overcome the resolution problems associated with current signature analysis, the signal is preprocessed using advanced signal processing tools. High resolution techniques like matrix pencil method and wavelet de-noising are implemented to estimate the fault severity. Conventional pencil method have not shown good indication for fault due to domination of pre-fault components like fundamental and harmonics. The Wiener filter cancellation is used to remove these pre-fault components and the fault indexing parameter is calculated to estimate the fault existence and its development. The proposed fault detection criteria is tested using experimental verification on 1.5kW induction motor.
Synthesis of (R)-Sibutramine (2006)

Sibutramine is an anorexic agent. The key step in its synthesis is an asymmetric reduction of the N-sulfinylketimine D derived from the readilly available N-tosyl-1,2,3-oxathiazolidine-2-oxide (C) which can be reconstituted from its hydrolysis product F.
Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes (2022)

Human coronavirus OC43 is a globally circulating common cold virus sustained by recurrent reinfections. How it persists in the population and defies existing herd immunity is unknown. Here we focus on viral glycoprotein S, the target for neutralizing antibodies, and provide an in-depth analysis of its antigenic structure. Neutralizing antibodies are directed to the sialoglycan-receptor binding site in S1<sub>A</sub> domain, but, remarkably, also to S1<sub>B</sub>. The latter block infection yet do not prevent sialoglycan binding. While two distinct neutralizing S1<sub>B</sub> epitopes are readily accessible in the prefusion S trimer, other sites are occluded such that their accessibility must be subject to conformational changes in S during cell-entry. While non-neutralizing antibodies were broadly reactive against a collection of natural OC43 variants, neutralizing antibodies generally displayed restricted binding breadth. Our data provide a structure-based understanding of protective immunity and adaptive evolution for this endemic coronavirus which emerged in humans long before SARS-CoV-2.
Direct Access to Metal or Metal Oxide Nanocrystals Integrated with One-Dimensional Nanoporous Carbons for Electrochemical Energy Storage (2010)

Metal and metal oxide nanocrystals have sparked great interest due to their excellent catalytic, magnetic, and electronic properties. Particularly, the integration of metallic nanocrystals and one-dimensional (1D) electronically conducting carbons to form metal-carbon hybrids can lead to enhanced physical and chemical properties or even the creation of new properties with respect to single component materials. However, direct access to thermally stable and structurally ordered 1D metal-carbon hybrids remains a primary challenge. We report an in situ fabrication of Co(3)O(4) or Pt nanocrystals incorporated into 1D nanoporous carbons (NPCs) via an organometallic precursor-controlled thermolysis approach. The AB(2)-type (one diene and two dienophile) 3,4-bis(4-dodecynylphenyl)-substituted cyclopentadienone and its relevant cobalt or platinum complex are first impregnated into the nanochannels of AAO (anodic alumina oxide) membranes. The intermolecular Diels-Alder reaction of these precursor molecules affords the formation of cobalt or platinum functionalized polyphenylene skeletons. Subsequent thermolysis transforms the polyphenylene backbones into 1D nanoporous carbonaceous frameworks, while the metallic moieties are reduced into Co or Pt nanocrystals, respectively. After removal of the AAO template, 1D NPCs/Co(3)O(4) or NPCs/Pt are obtained, for which structural characterizations reveal that high-quality Co(3)O(4) or Pt nanocrystals are distributed homogeneously within carbon frameworks. These unique 1D metal-carbon hybrids exhibit a promising potential in electrochemical energy storage. NPCs/Co(3)O(4) is evaluated as an electrode material in a supercapacitor, for which Co(3)O(4) nanocrystals contribute an exceptionally high gravimetric capacitance value of 1066 F g(-1). NPCs/Pt is applied as an electrocatalyst showing excellent catalytic efficiency toward methanol oxidation in comparison to commercial E-TEK (Pt/C) catalyst.
Ultrafast Intersubband Relaxation Dynamics and Coherent Nonlinearity in Bulk and Waveguide structures of GaN/AlN Multiple Quantum Wells (2007)

We have investigated the detailed ultrafast electronic relaxation dynamics and coherent nonlinearity at optical communication wavelength in GaN/AlN multiple quantum wells (MQWs), using spectral‐integrated and — resolved two‐color pump‐probe techniques in a wide energy range. First, we found that the ISBT relaxation dynamics consists of the ultrafast (∼140 fs) intersubband relaxation and slow (∼1.3 ps) carrier cooling process. Second, we have observed coherent spectrum oscillations, which show that the ISBT dephasing time is more than 100 fs at a room temperature. Finally, we have observed the polarization‐dependent absorption in waveguide structures.
ChemInform Abstract: Monomeric Tungsten(IV) Phenoxide and Thiolate Complexes. (1986)

Abstract Im Hinblick auf die mögliche Fähigkeit, kleine Moleküle zu binden und zu aktivieren, wurden die bisher nicht bekannten Titelverbindungen (II) bzw. (V) dargestellt.
Recombinant invasive Lactococcus lactis can transfer DNA vaccines either directly to dendritic cells or across an epithelial cell monolayer (2015)

Lactococcus lactis (L. lactis), a generally regarded as safe (GRAS) bacterium has recently been investigated as a mucosal delivery vehicle for DNA vaccines. Because of its GRAS status, L. lactis represents an attractive alternative to attenuated pathogens. Previous studies showed that eukaryotic expression plasmids could be delivered into intestinal epithelial cells (IECs) by L. lactis, or recombinant invasive strains of L. lactis, leading to heterologous protein expression. Although expression of antigens in IECs might lead to vaccine responses, it would be of interest to know whether uptake of L. lactis DNA vaccines by dendritic cells (DCs) could lead to antigen expression as they are unique in their ability to induce antigen-specific T cell responses. To test this, we incubated mouse bone marrow-derived DCs (BMDCs) with invasive L. lactis strains expressing either Staphylococcus aureus Fibronectin Binding Protein A (LL-FnBPA+), or Listeria monocytogenes mutated Internalin A (LL-mInlA+), both strains carrying a plasmid DNA vaccine (pValac) encoding for the cow milk allergen β-lactoglobulin (BLG). We demonstrated that they can transfect BMDCs, inducing the secretion of the pro-inflammatory cytokine IL-12. We also measured the capacity of strains to invade a polarized monolayer of IECs, mimicking the situation encountered in the gastrointestinal tract. Gentamycin survival assay in these cells showed that LL-mInlA+ is 100 times more invasive than L. lactis. The cross-talk between differentiated IECs, BMDCs and bacteria was also evaluated using an in vitro transwell co-culture model. Co-incubation of strains in this model showed that DCs incubated with LL-mInlA+ containing pValac:BLG could express significant levels of BLG. These results suggest that DCs could sample bacteria containing the DNA vaccine across the epithelial barrier and express the antigen.