gebhart/patrepeval huggingface dataset:
A TEMPO-mediated ?living? free-radical approach to ABA triblock dendritic linear hybrid copolymers (1999)

Dumbbell-shaped ABA triblock copolymers composed of benzyl ether dendrons and polystyrene as the A and B blocks, respectively, were prepared using 2,2,6,6-tetramethylpiperidinyl-1-oxy (TEMPO) -mediated “living” free-radical polymerization. A new bis-dendritic unimolecular initiator, compound 3, was employed to study the efficiency of ABA triblock formation under standard TEMPO-mediated polymerization conditions. By this design, the central B block of the ABA triblock copolymer was grown into the bis-dendritic unimolecular initiator. The ABA triblock copolymer products were separated from their by-products, AB diblock copolymers, by column chromatography on silica gel. The isolated copolymers were characterized using gel permeation chromatography and proton nuclear magnetic resonance spectroscopy as complimentary techniques. That the dendritic-linear AB diblock copolymer was obtained in a mixture with ABA triblock material indicates that TEMPO-terminated dendron counter-radical 5 is an imperfect mediator of this free-radical polymerization. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 3748–3755, 1999
Online Decomposition of Compressive Streaming Data Using n-l1 Cluster-Weighted Minimization (2018)

We consider a decomposition method for compressive streaming data in the context of online compressive Robust Principle Component Analysis (RPCA). The proposed decomposition solves an n-ℓ1 cluster-weighted minimization to decompose a sequence of frames (or vectors), into sparse and low-rank components from compressive measurements. Our method processes a data vector of the stream per time instance from a small number of measurements in contrast to conventional batch RPCA, which needs to access full data. The n-ℓ1 cluster-weighted minimization leverages the sparse components along with their correlations with multiple previously-recovered sparse vectors. Moreover, the proposed minimization can exploit the structures of sparse components via clustering and re-weighting iteratively. The method outperforms the existing methods for both numerical data and actual video data.
Intentional infliximab use during pregnancy for induction or maintenance of remission in Crohn's disease (2005)

This is the first reported series of intentional infliximab use throughout pregnancy. These data, combined with other studies of inadvertent use of infliximab during pregnancy, suggest that the benefits of infliximab in achieving response and maintaining remission in mothers with Crohn's disease may outweigh the risk to the foetus of exposure to the drug. Further prospective data collection will be helpful to confirm these findings.
Clinical evaluation of HER2 molecular diagnostic assay with internal quality controls in breast cancer. (2016)

e23130 Background: Determination of HER2 status before taking therapeutic regimens plays an essential role in breast cancer. Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) are currently working assays for HER2 testing. With the advantages of cost-effectiveness and high accuracy for IHC and FISH respectively, these two assays have been recommended as the routinely-used diagnostic tool. However, several studies has been reported that false signals and lab-to-lab variations are major unsolved issues for HER2 testing. Moreover, both IHC and FISH assays do not have the internal quality control mechanism, which might be the root-causes of the issues that we’re facing. Methods: Here, we developed and evaluated a novel HER2 testing assay with built-in internal quality control mechanisms by the principle of multiplex real-time PCR. Results: Fifty FFPE samples were collected and analyzed for the evaluation. The result showed that the agreement between the developed assay and FDA certified FISH assay is over 90%, suggesting the developed Real-Time PCR is accurate and reliable for HER2 testing. Furthermore, the quality of FFPE samples can be distinguished simultaneously, which can prevent false signals or lab-to-lab variations that resulted from poor qualified samples. Conclusions: To sum up, the clinical efficacy of the developed HER2 molecular diagnostic assay shows great quality control ability and high analytical consistency with current assays for HER2 testing.
Figure S1 from An Orally Available Tubulin Inhibitor, VERU-111, Suppresses Triple-Negative Breast Cancer Tumor Growth and Metastasis and Bypasses Taxane Resistance (2023)

&lt;p&gt;Figure S1 shows that VERU-111 inhibits TNBC cell migration and invasion at 16 nM. (A) Representative images of migration assays showing MDA-MB-231 (upper panel) and MDA-MB-468 (lower panel) cells treated with VERU-111 (16 nM) for 24 h and 48 h, respectively, that have migrated through transwell membrane inserts. (B) Representative images of invasion assays showing MDA-MB-231 (upper panel) and MDA-MB-468 (lower panel) cells treated with VERU-111 (16 nM) for 24 h and 48 h, respectively, using Matrigel-coated transwell membrane inserts. All data are presented as the grand mean {plus minus} SEM of three independent experiments, with p-values determined relative to the Control group (normalized to 100%), scale bar = 100 µm.&lt;/p&gt;
Benefit of Cardiopoietic Mesenchymal Stem Cell Therapy on Left Ventricular Remodelling: Results from the Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) Study (2017)

In CHART-1, intramyocardial administration of cardiopoietic stem cells led to reverse remodelling as evidenced by significant progressive decreases in LVEDV and LVESV through the 52 weeks of follow-up. Further studies are needed to explore the dose response with regard to cell number and injected volume, and reverse remodelling.
Requirement of IL-5 for induction of autoimmune hemolytic anemia in anti-red blood cell autoantibody transgenic mice (1999)

IL-5, IL-10 and lipopolysaccharide (LPS) are known to activate B-1 cells in vivo in normal mice and anti-red blood cell autoantibody transgenic mice (HL mice). To assess the exact role of IL-5 in proliferation and activation of peritoneal B-1 cells, we analyzed IL-5 receptor alpha chain-deficient HL (IL-5Ralpha-/- x HL) mice generated by the cross between IL-5Ralpha-/- and HL mice. In IL-5Ralpha-/- x HL mice, Ig-producing B-1 cells in the peritoneal cavity were negligible, although the total number of B-1 cells in the peritoneal cavity were as many as 30% of that in HL mice. Moreover, LPS- or IL-10-induced differentiation of B-1 cells into antibody-producing cells was severely impaired in IL-5Ralpha-/- x HL mice. We also used in vivo 5-bromo-2'-deoxyuridine labeling to estimate the proliferation of B-1 cells in IL-5Ralpha-/- mice. The absence of IL-5Ralpha did not affect spontaneous proliferation of peritoneal B-1 cells. However, induced proliferation of peritoreal B-1 cells by oral administration of LPS was markedly impaired in IL-5Ralpha-/- mice. These results suggest that IL-5 is required for activation-associated proliferation of B-1 cells but not for their spontaneous proliferation and support the idea that IL-5 plays an important role on the induction of autoantibody production from B-1 cells.
DOES INCREASED BONE TURNOVER EXPLAIN HIGH BLOOD LEAD LEVELS IN END-STAGE RENAL DISEASE PATIENTS? (2007)

Higher blood lead levels, a risk factor for cardiovascular disease, have been reported among patients with end-stage renal disease. We sought to determine whether higher lead levels in end-stage renal disease patients are due to lead being released from the skeleton. Fifty-one African American patients with end-stage renal disease were recruited from three Tulane University-affiliated dialysis clinics between January and July 2005. An interviewer-administered questionnaire, blood specimen collection, and 109Cd x-ray fluorescence measurement of tibia lead occurred during a single study visit. In addition, levels of serum parathyroid hormone (PTH), calcium, phosphorus, and albumin were abstracted from patients9 charts. The distributions of tibia and blood lead were similar across levels of serum PTH. Specifically, the median tibia lead was 21 μg/g and 17 μg/g for participants with PTH levels .40). The high blood lead levels observed among end-stage renal disease patients do not appear to be the result of increased bone turnover. The causes of higher blood lead levels for these patients need to be identified and attenuated.
A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent (2020)

Plasmodium parasites kill 435 000 people around the world every year due to unavailable vaccines, a limited arsenal of antimalarial drugs, delayed treatment, and the reduced clinical effectiveness of current practices caused by drug resistance. Therefore, there is an urgent need to discover and develop new antiplasmodial candidates. In this work, we present a novel strategy to develop a multitarget metallic hybrid antimalarial agent with possible dual efficacy in both sexual and asexual erythrocytic stages. A hybrid of antimalarial drugs (chloroquine and primaquine) linked by gold(I) was synthesized and characterized by spectroscopic and analytical techniques. The CQPQ-gold(I) hybrid molecule affects essential parasite targets, it inhibits β-hematin formation and interacts moderately with the DNA minor groove. Its interaction with PfTrxR was also examined in computational modeling studies. The CQPQ-gold(I) hybrid displayed an excellent in vitro antimalarial activity against the blood-stage of Plasmodium falciparum and liver-stage of Plasmodium berghei and efficacy in vivo against P. berghei, thereby demonstrating its multiple-stage antiplasmodial activity. This metallic hybrid is a promising chemotherapeutic agent that could act in the treatment, prevention, and transmission of malaria.
Exploration of alternative scaffolds for P2Y14 receptor antagonists containing a biaryl core (2020)

Various heteroaryl and bicyclo-aliphatic analogues of zwitterionic biaryl antagonists of the P2Y<sub>14</sub> receptor (P2Y<sub>14</sub>R) were synthesized and tested for affinity in P2Y<sub>14</sub>R-expressing CHO cells by flow cytometry. Given this series’ low water solubility, various polyethylene glycol derivatives of a distally binding piperidin-4-yl moiety of moderate
Smartphone-based pathogen diagnosis in urinary sepsis patients (2018)

The smaRT-LAMP system is effective against diverse Gram-negative and -positive pathogens and biological specimens, costs less than $100 US to fabricate (in addition to the smartphone), and is configurable for the simultaneous detection of multiple pathogens. SmaRT-LAMP thus offers the potential to deliver rapid diagnosis and treatment of urinary tract infections and urinary sepsis with a simple test that can be performed at low cost at the point-of-care. FUND: National Institutes of Health, Chan-Zuckerberg Biohub, Bill and Melinda Gates Foundation.
Faster, Parametric Trajectory-based Macromodels Via Localized Linear Reductions (2006)

Trajectory-based methods offer an attractive methodology for automated, on-demand generation of macro-models for custom circuits. These models are generated by sampling the state trajectory of a circuit as it simulates in the time domain, and building macromodels by reducing and interpolating among the linearizations created at a suitably spaced subset of the time points visited during training simulations. However, a weak point in conventional trajectory models is the reliance on a single, global reduction matrix for the state space. We develop a new, faster method that generates and weaves together a larger set of smaller localized linearizations for the trajectory samples. The method not only improves speedups to 30times over SPICE, but as a side benefit also provides a platform for parametric small-signal simulation of circuits with variational device/process parameters, at a speedup of roughly 200times over SPICE
Overview and Future Challenge of Ferroelectric Random Access Memory Technologies (2007)

We have developed a low-temperature formation technique for ferroelectrics (<500 °C), which is crucial for the ferroelectric random access memory (FeRAM) to be embedded in a leading-edge complementary metal oxide semiconductor (CMOS). A 53-nm-thick Bi4Ti3O12 film was successfully formed by metalorganic chemical vapor deposition at 450 °C and subsequent annealing at 500 °C. It was found that perovskite grains preferentially orient along the (110) and (111) directions and that the fabricated Bi4Ti3O12 capacitors show a remnant polarization (2Pr) of as large as 25.7 µC/cm2. In addition, we have adopted a nondestructive readout operation (NDRO) technique to extend read cycle endurance, in which the switched polarization at reading is automatically rewritten by readout voltage removal. We have demonstrated stable readout characteristics at more than 1011 cycles for 0.18 µm NDRO FeRAMs.
Fluorescence depolarization studies of sol-gel-derived glasses using a rigidochromic probe (1992)

The rigidochromic molecule rhenium(I)chlorotricarbonyl-2,2'-bipyridine was used in fluorescence depolarization experiments to probe the gelation, aging, and drying of silica and aluminosilicate sol-gel derived materials. These studies indicate that the local environment of the probe is fluid until well after gelation has occurred. Aluminosilicate gels show an increase in local viscosity after gelation while silica gels show no increase until the drying stage is begun. These results are compared to previous studies in which the shift of the emission band was used to indicate the rigidity in the local environment of the probe.
A Synthesis Strategy Yielding Skeletally Diverse Small Molecules Combinatorially (2004)

The efficient synthesis of small molecules having many molecular skeletons is an unsolved problem in diversity-oriented synthesis (DOS). We describe the development and application of a synthesis strategy that uses common reaction conditions to transform a collection of similar substrates into a collection of products having distinct molecular skeletons. The substrates have different appendages that pre-encode skeletal information, called sigma-elements. This approach is analogous to the natural process of protein folding in which different primary sequences of amino acids are transformed into macromolecules having distinct three-dimensional structures under common folding conditions. Like sigma-elements, the amino acid sequences pre-encode structural information. An advantage of using folding processes to generate skeletal diversity in DOS is that skeletal information can be pre-encoded into substrates in a combinatorial fashion, similar to the way protein structural information is pre-encoded combinatorially in polypeptide sequences, thus making it possible to generate skeletal diversity in an efficient manner. This efficiency was realized in the context of a fully encoded, split-pool synthesis of approximately 1260 compounds potentially representing all possible combinations of building block, stereochemical, and skeletal diversity elements.
Axially Modulated Clamped-Guided Arch Resonator for Memory and Logic Applications (2017)

We experimentally demonstrate memory and logic devices based on an axially modulated clamped-guided arch resonator. The device are electrostatically actuated and capacitively sensed, while the resonance frequency modulation is achieved through an axial electrostatic force from the guided side of the clamped-guided arch microbeam. We present two case studies: first, a dynamic memory based on the nonlinear frequency response of the resonator, and second, a reprogrammable two-input logic gate based on the linear frequency modulation of the resonator. These devices show energy cost per memory/logic operation in pJ, are fully compatible with CMOS fabrication processes, have the potential for on-chip system integration, and operate at room temperature.
Data Physicalization (Dagstuhl Seminar 18441) (2019)

Data physicalization involves representing numbers and relationships using physical, tangible displays. These displays provide tactile, as well as visual metaphors for expressing and experiencing data, and can unlock new analytical insights and emotional responses. This Dagstuhl seminar brought together a diverse group of researchers and practitioners to explore the benefits and challenges of physicalization - computer scientists trained in visualization, virtual reality and human-computer interaction; architects of virtual and augmented systems; perceptual and cognitive scientists; and artists and designers. Through interactive discussions and demonstrations, we explored physicalization, as a set of methodologies for representing data, for engaging audiences, and for artistic expression.
CHANGES IN PERIPHERAL BLOOD CELLS AND SERUM FERRITIN IN LYSINURIC PROTEIN INTOLERANCE (1980)

Twenty-seven patients with lysinuric protein intolerance, an autosomal recessive disorder of diamino acid transport, have been followed at our hospital since 1965. Many of the patients had recurrent mild normochromic anaemia without apparent iron deficiency, and leuko- and/or thrombocytopenia. Serum ferritin concentrations were inappropriately high. Serum ferritin concentration appears to be a valuable index of the control of this disease.
Stress Generation and Tailoring of Electronic Properties of Expanded Graphite by Click Chemistry (2014)

The generation of stress in expanded graphite (E-GPT) due to covalent attachment of bulky side groups connected via a hetero atom is reported. Specifically, E-GPT is modified at different levels of grafting using "click" chemistry to graft 1-ethynyl-4-fluoro benzene onto graphene sheets via a triazole ring. In the range of grafting densitites examined, Raman spectroscopy indicates that the stress generated in graphene is linearly dependent on the extent of grafting. The functionalized graphene platelets with 6% functionalization transform from semi-metal behavior of the pristine material to semi-conductor behavior and indicates the ability of functionalization to change optical and electronic properties of graphene platelets similar to the deposition of thin layers of top gate oxides onto graphene.
66‐1: Invited Paper: Hole‐Transport Materials — Key Enablers for Future OLED Display Evolution (2022)

This article gives a short review on current development fields of hole transport materials for organic light emitting diodes. A special focus is set on the paradigm shift observed by an increasing relevance to control panel performance parameters beyond classical device characteristics like driving voltage, efficiency, and lifetime. This requires new material design approaches by new measurement and simulation techniques as well as new molecular properties to be considered in material design concepts.
Photochemical cleavage of a polymeric solid: details of the ultraviolet laser ablation of poly(methyl methacrylate) at 193 nm and 248 nm (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemical cleavage of a polymeric solid: details of the ultraviolet laser ablation of poly(methyl methacrylate) at 193 nm and 248 nmR. Srinivasan, B. Braren, D. E. Seeger, and R. W. DreyfusCite this: Macromolecules 1986, 19, 3, 916–921Publication Date (Print):March 1, 1986Publication History Published online1 May 2002Published inissue 1 March 1986https://pubs.acs.org/doi/10.1021/ma00157a074https://doi.org/10.1021/ma00157a074research-articleACS PublicationsRequest reuse permissionsArticle Views456Altmetric-Citations152LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Confidence of model based shape reconstruction from sparse data (2010)

Statistical shape models (SSM) are commonly applied for plausible interpolation of missing data in medical imaging. However, when fitting a shape model to sparse information, many solutions may fit the available data. In this paper we derive a constrained SSM to fit noisy sparse input landmarks and assign a confidence value to the resulting reconstructed shape. An evaluation study is performed to compare three methods used for sparse SSM fitting w.r.t. specificity, generalization ability, and correctness of estimated confidence limits with an increasing amount of input information. We find that the proposed constrained shape model outperforms the other models, is robust against the selection and amount of sparse information, and indicates the shape confidence well.
Optimisation et intégration de catalyseurs structurés en réacteurs structurés pour la conversion de CO₂ en méthane (2017)

In this doctoral study, the three dimensional fibre deposition (3DFD) technique has been applied to develop and manufacture advanced multi-channelled catalytic support structures. By using this technique, the material, the porosity, the shape and size of the channels and the thickness of the fibres can be controlled. The aim of this research is to investigate the possible benefits of 3D-designed structured supports for CO2 methanation in terms of activity, selectivity and stability and the impact of specific properties introduced in the structural design of the supports.
In-vivo measurements of axon radius and density in the corpus callosum using anomalous diffusion from diffusion MRI (2015)

Axon radius and packing density provide information on the role and performance of white-matter pathways. MRI researchers have tried to measure axon radius, however, they assumed the radius of axons follows a gamma distribution or a single axon radius was considered. From diffusion-weighted data, we mapped axon radii and packing density in the corpus callosum by fitting the parameters of the space fractional Bloch-Torrey anomalous diffusion model. We were able to calculate axon radii and packing density without any assumptions of axon radius. We found the values of axon radii to be in good agreement with previous findings.
Focal therapy for kidney cancer: a systematic review (2009)

Currently, data on the ability of interventions for SRMs to affect the natural history of these masses are lacking. Prospective randomized evaluations of available clinical approaches to SRMs are needed.
Supplementary Table 2 from Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma (2023)

&lt;p&gt;Sequences&lt;/p&gt;