gebhart/patrepeval huggingface dataset:
Cellular and humoral immune responses of jirds resistant to Dipetalonema viteae infection (1986)

Jirds with prepatent Dipetalonema viteae infections develop an acquired immunity to challenge infections. The objective of the present study was to observe parasite-specific and nonspecific cellular and humoral immune responses in immune jirds. Splenic hyperplasia was observed in infected jirds during the first 5 weeks of infection. Antigen-reactive spleen cells were observed in the lymphocyte transformation assay at 3 weeks postinfection. A depressed response to concanavalin A (ConA) was seen at 1 week postinfection through week 5. Mitomycin C-treated cells from infected jirds were capable of suppressing the response of normal cells to ConA. Sephadex G-10-nonadherent spleen cells from infected jirds showed elevated responses to D. viteae antigen at 1, 3, and 5 weeks and elevated responses to ConA at 3 and 5 weeks. Filaria-specific antibodies were seen at 1 week postinfection, and titers rose through week 5. Plaque-forming cell production to sheep erythrocytes was not depressed in infected jirds. It was concluded that jirds react immunologically with both cellular and humoral responses during the prepatent period of D. viteae infection. A concurrent immune depression was seen. Its effect on resistance and tolerance remains to be determined.
Printable, flexible and stretchable diamond for thermal management (2023)

Various heat-sinked components and methods of making heat-sinked components are disclosed where diamond in thermal contact with one or more heat-generating components are capable of dissipating heat, thereby providing thermally-regulated components. Thermally conductive diamond is provided in patterns capable of providing efficient and maximum heat transfer away from components that may be susceptible to damage by elevated temperatures. The devices and methods are used to cool flexible electronics, integrated circuits and other complex electronics that tend to generate significant heat. Also provided are methods of making printable diamond patterns that can be used in a range of devices and device components.
Supplementary Table S4 from Integrated Genomic Characterization of the Human Immunome in Cancer (2023)

&lt;p&gt;Table S4. Gene mutations that perturb binding of HLAs.&lt;/p&gt;
The Novel, Nicotinic Alpha7 Receptor Partial Agonist, BMS-933043, Improves Cognition and Sensory Processing in Preclinical Models of Schizophrenia (2016)

The development of alpha7 nicotinic acetylcholine receptor agonists is considered a promising approach for the treatment of cognitive symptoms in schizophrenia patients. In the present studies we characterized the novel agent, (2R)-N-(6-(1H-imidazol-1-yl)-4-pyrimidinyl)-4'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazol]-2'-amine (BMS-933043), in vitro and in rodent models of schizophrenia-like deficits in cognition and sensory processing. BMS-933043 showed potent binding affinity to native rat (Ki = 3.3 nM) and recombinant human alpha7 nicotinic acetylcholine receptors (Ki = 8.1 nM) and agonist activity in a calcium fluorescence assay (EC50 = 23.4 nM) and whole cell voltage clamp electrophysiology (EC50 = 0.14 micromolar (rat) and 0.29 micromolar (human)). BMS-933043 exhibited a partial agonist profile relative to acetylcholine; the relative efficacy for net charge crossing the cell membrane was 67% and 78% at rat and human alpha7 nicotinic acetylcholine receptors respectively. BMS-933043 showed no agonist or antagonist activity at other nicotinic acetylcholine receptor subtypes and was at least 300 fold weaker at binding to and antagonizing human 5-HT3A receptors (Ki = 2,451 nM; IC50 = 8,066 nM). BMS-933043 treatment i) improved 24 hour novel object recognition memory in mice (0.1-10 mg/kg, sc), ii) reversed MK-801-induced deficits in Y maze performance in mice (1-10 mg/kg, sc) and set shift performance in rats (1-10 mg/kg, po) and iii) reduced the number of trials required to complete the extradimensional shift discrimination in neonatal PCP treated rats performing the intra-dimensional/extradimensional set shifting task (0.1-3 mg/kg, po). BMS-933043 also improved auditory gating (0.56-3 mg/kg, sc) and mismatch negativity (0.03-3 mg/kg, sc) in rats treated with S(+)ketamine or neonatal phencyclidine respectively. Given this favorable preclinical profile BMS-933043 was selected for further development to support clinical evaluation in humans.
A 25 Gb/s 60 GHz digital power amplifier in 28nm CMOS (2017)

This paper presents a 60 GHz class-E digital power amplifier (DPA) that generates energy-efficient, non-constant envelope modulations up to 25 Gb/s. The DPA achieves a peak drain efficiency of 17.7% at a V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">sat</sub> of 7.4 dBm. By means of direct digital amplitude modulation of the 6-bit output stage, the DPA produces error-free, high-order constellations (16-QAM, 32-QAM, 64-QAM) up to 5 GSym/s with error vector magnitudes (EVMs) <;-26 dB. Compared to prior 60 GHz DPAs, >3.5X higher data rates at comparable average efficiencies is achieved.
Overexpression of SH2-SH2-SH3 Domain of Phospholipase C-γ1 Blocks PDGF -induced Inositol Phosphate Generation in NIH 3T3 Cells (1996)

Src homology (SH) 2 and 3 domains are known to be binding motifs for protein-protein interaction in signaling molecules. Among several PLC isozymes, only PLC-γ contains the SH domain between the X and Y domains, which are known to have catalytic activity. To elucidate the functional roles of the SH2-SH2-SH3 domain of PLC-γ1 in cellular signaling, we constructed a truncated cDNA encoding the SH2-SH2-SH3 domain of PLC-γ1 (p60SH2/SH3) and expressed it in NIH 3T3 cells. Cells expressing p60SH2/SH3 did not show any change in cell shape no oncogenesity. Even though in a serum depleted condition, a portion of p60SH2/SH3 existed as constitutively phosphorylated on its tyrosine residues. Furthermore, cells expressing p60SH2/SH3 did not respond to PDGF-induced IPs formation whereas vector-transfected control cells showed dose-dependent IPs generation upon PDGF stimulation. The tyrosine phosphorylation level of endogenous PLC-γ1 by PDGF, however, was comparable to that of the control cells. On the other hand, IPs accumulation by PLC-β activation occurred to a comparable level. Taken together, p60SH2/SH3 molecules selectively inhibited the IPs accumulation catalyzed by PLC-γ1. This result suggests that the SH2-SH2-SH3 domain is essential for PLC-γ1-mediated cellular signaling, including its own catalytic activity by protein-protein interaction.
Annealing of Ge nanocrystals on Si(001) at550°C: Metastability of huts and the stability of pyramids and domes (1998)

We performed a series of annealing experiments for Ge nanocrystals on Si(001) at $550\ifmmode^\circ\else\textdegree\fi{}\mathrm{C}$ in order to clarify some issues related to island stability and coarsening. We determined the nanocrystal shape and size distributions for 8 Ge equivalent monolayers as a function of annealing time for up to 80 min after terminating the depositions. Elongated islands or ``huts'' disappear within 30 s, leaving only equiaxial islands, the ``pyramids'' and ``domes.'' During the first 10 min of annealing, the nanocrystals grow further by drawing additional Ge from the wetting layer. Thereafter, the pyramid and dome size distributions are stable.
Announcing a special issue of the IEEE journal of quantum electonics on solid-state lasers (1987)

Provides upcoming special issue information of interest to practitioners and researchers.
Infrared Study of the Decomposition of Carbon Suboxide over Supported Rhodium (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfrared Study of the Decomposition of Carbon Suboxide over Supported RhodiumZ. Pei and S. D. WorleyCite this: J. Phys. Chem. 1994, 98, 19, 5135–5137Publication Date (Print):May 1, 1994Publication History Published online1 May 2002Published inissue 1 May 1994https://pubs.acs.org/doi/10.1021/j100070a032https://doi.org/10.1021/j100070a032research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Qualitative Reasoning for Decision Synthesis (2001)

Abstract A qualitative reasoning approach is presented for decision support. This approach is initiated with the generation and normalization of a qualitative model including relationship matrix, importance weightings, control limits for decision variables, and specification limits for performance attributes. An extensive Simplex method is then utilized for mapping the global feasibility of the decision problem. Finally, the approach interprets and simplifies the results from the multi-dimensional feasibility space back to the qualitative model. The paper also presents application of the approach to process tuning of multilayer sheet extrusion and concept development of a 2nd generation reusable launch vehicle to orbit. The results indicate that the developed approach is a viable alternative to currently practiced decision analysis methods. Specifically, the approach uses: 1) tightened specification limits rather than a weighted multi-attribute objective relationship, 2) determines global system feasibility from active constraints rather than local parametric optimization, and 3) establishes correlations based on dynamic Pareto-optimal frontiers rather than manual estimations. While the approach is potentially useful, further research is required to extend the methods to non-linear, stochastic, and uncharacterized engineering systems.
<title>Pipette SNOM/AFM probe applicable to any wavelength and combination with confocal microscope</title> (1999)

A novel pipette SNOM/AFM probe has been developed for its simple fabrication and applicability to wide wavelength range. The pipette probe is simply fabricated by a successive process of pulling, bending with a CO<SUB>2</SUB> laser, making a hole and coating with a metal layer. The hole is made on the tube at the back side of the tip for applying a light. The pipette probe is mounted on the SNOM/AFM system which includes a confocal microscope. The light is introduced to the hole directly by focusing from a confocal microscope or through an optical fiber. The probe provided clear topographic and optical images for a sample of a patterned chromium layer on a glass substrate and fluorescence beads. A confocal images was also obtained in a wide area of the same samples.
[Dermatoglyphic diagnosis in patients with atopic eczema]. (1992)

The purpose of this investigation was to find out whether the new Dermalog system could be used in conjunction with dermatoglyphics in patients with atopic dermatitis. For this purpose, 92 patients with atopic eczema (58 women and 34 men) were examined and were compared with two different control groups. The first control group, representing the normal population, consisted of 100 female and 100 male randomly selected subjects. The second control group (55 women and 24 men) excluded any persons with a history of atopic syndrome. First of all, hand and fingerprints were taken. The data were stored in a computer and were statistically analysed with the aid of significance and discrimination tests. Evaluation of the patients' data showed no significant difference from the first control group. Results in the second, selected, control group were better. For example, in this group, in which the probability was 93.1%, 76.4% of the women examined were found to have atopic dermatitis. The probability among the male patients examined was 99.9% and the corresponding sensitivity, 77.0%.
RDA: An Accelerated Collision Free Motion Planner for Autonomous Navigation in Cluttered Environments (2022)

Autonomous motion planning is challenging in multi-obstacle environments due to nonconvex collision avoidance constraints. Directly applying numerical solvers to these nonconvex formulations fails to exploit the constraint structures, resulting in excessive computation time. In this paper, we present an accelerated collision-free motion planner, namely regularized dual alternating direction method of multipliers (RDADMM or RDA for short), for the model predictive control (MPC) based motion planning problem. The proposed RDA addresses nonconvex motion planning via solving a smooth biconvex reformulation via duality and allows the collision avoidance constraints to be computed in parallel for each obstacle to reduce computation time significantly. We validate the performance of the RDA planner through path-tracking experiments with car-like robots in both simulation and real-world settings. Experimental results show that the proposed method generates smooth collision-free trajectories with less computation time compared with other benchmarks and performs robustly in cluttered environments. The source code is available at https://github.com/hanruihua/RDA_planner.
Evaluating the importance of routine drainage following laparoscopic pelvic lymph node dissection for gynecological malignancies (2020)

Our results suggest that routine drainage should be omitted, especially in cases involving laparoscopic surgery.
Precursor flux control through targeted chromosomal insertion of the lysine epsilon-aminotransferase (lat) gene in cephamycin C biosynthesis (1993)

Targeted gene insertion methodology was used to study the effect of perturbing alpha-aminoadipic acid precursor flux on the overall production rate of beta-lactam biosynthesis in Streptomyces clavuligerus. A high-copy-number plasmid containing the lysine epsilon-aminotransferase gene (lat) was constructed and used to transform S. clavuligerus. The resulting recombinant strain (LHM100) contained an additional complete copy of lat located adjacent to the corresponding wild-type gene in the chromosome. Biological activity and production levels of beta-lactam antibiotics were two to five times greater than in wild-type S. clavuligerus. Although levels of lysine epsilon-aminotransferase were elevated fourfold in LHM100, the level of ACV synthetase, whose gene is located just downstream of lat, remained unchanged. These data strongly support the notion that direct perturbation of alpha-aminoadipic acid precursor flux resulted in increased antibiotic production. This strategy represents a successful application of metabolic engineering based on theoretical predictions of precursor flux in a secondary metabolic pathway.
Identification of novel markers for liver fibrosis in HIV/hepatitis C virus coinfected individuals using genomics-based approach (2008)

Both models accurately predicted fibrosis with an accuracy of 87.9%, thereby sparing 83% of patients from obtaining a biopsy. DNA microarray analysis can be invaluable in identifying novel biomarkers of liver fibrosis.
Strengthened lithium for x-ray blast windows (2008)

Lithium's high x-ray transparency makes it an attractive material for windows intended to protect soft x-ray diagnostics in high energy density experiments. Pure lithium is soft and weak, but lithium mixed with lithium hydride powder becomes harder and stronger, in principle without any additional x-ray absorption. A comparison with the standard material for x-ray windows, beryllium, suggests that lithium or lithium strengthened by lithium hydride may well be an excellent option for such windows.
An investigation into perceptual hue-ordering (2008)

There are a number of problems for which colour-vectors need to be ordered: vector morphology and colour-to-greyscale conversion are two important examples. A lexicographic ordering can perform this function, but while the luminance and saturation components have clearly defined scales with fixed origins there is no such scale for the hue dimension. In this paper we tackle this problem directly using a greyscale assignment paradigm. Observers were shown pairs of iso-luminant and iso-saturation colours, and asked to assign greyscale values to them such that the assigned greyscale difference matched their perceived colour difference. From the resulting magnitudes we construct a 1D scale of hue values using multi-dimensional scaling, and the results show a sinusoid-like ordering. We also analyse the signs of the differences (i.e. which colour was assigned a brighter greylevel), and find that different observers reliably use the same sign-assignment strategy. This result can be used to fix the phase of the sinusoidal scale resulting from the magnitude experiments. This result also supplements earlier work on the Helmholtz-Kohlrausch effect, but is not the same as we have uniquely used colors that were set as iso-luminant and iso-saturation individually for each observer. Here we visualise the effect by encoding iso-luminant and iso-saturation images with the derived greyscale ordering.
Chaperone Activity of Small Heat Shock Proteins Underlies Therapeutic Efficacy in Experimental Autoimmune Encephalomyelitis (2012)

To determine whether the therapeutic activity of αB crystallin, small heat shock protein B5 (HspB5), was shared with other human sHsps, a set of seven human family members, a mutant of HspB5 G120 known to exhibit reduced chaperone activity, and a mycobacterial sHsp were expressed and purified from bacteria. Each of the recombinant proteins was shown to be a functional chaperone, capable of inhibiting aggregation of denatured insulin with varying efficiency. When injected into mice at the peak of disease, they were all effective in reducing the paralysis in experimental autoimmune encephalomyelitis. Additional structure activity correlations between chaperone activity and therapeutic function were established when linear regions within HspB5 were examined. A single region, corresponding to residues 73-92 of HspB5, forms amyloid fibrils, exhibited chaperone activity, and was an effective therapeutic for encephalomyelitis. The linkage of the three activities was further established by demonstrating individual substitutions of critical hydrophobic amino acids in the peptide resulted in the loss of all of the functions.
Identification of a two‐component regulatory system controlling methanol dehydrogenase synthesis in Paracoccus denitrificans (1993)

Upstream of the moxFJGIR genes of Paracoccus denitrificans a regulatory region involved in methanol oxidation was identified. The nucleotide sequence of this region was determined and revealed three genes, moxZ, moxY and moxX, which are transcribed opposite to moxF and which encode proteins of 16.4, 48.2 and 24.5 kDa, respectively. Computer alignment analysis revealed that the gene products of moxY and moxX have homology with the protein histidine kinases and the response regulators, respectively, forming the two-component regulatory systems. No significant homology of the moxZ gene product with any known protein, sequenced thus far, was found. The MoxZ, MoxY and MoxX proteins were identified in Escherichia coli in a heterologous expression system. Mutants with an insertion of a kanamycin-resistance marker in moxZ, moxY and moxX were isolated. These mutant strains were unable to grow on methanol while growth on methylamine was not affected. In the moxZ mutant both subunits of methanol dehydrogenase and cytochrome c551i were not synthesized, methanol dehydrogenase activity was absent, and hardly any expression of a moxZ-lacZ transcriptional fusion was found. Complementation of the mutation was observed after addition of the three genes moxZ, Y and X, in trans. This indicates that the two-component regulatory system is involved in activation of the moxF promoter. A mutant with an unmarked deletion in moxZ was isolated. This mutant showed reduced growth on methanol relative to the wild type. Expression of the moxF-lacZ transcriptional fusion gene and methanol dehydrogenase activity in this strain were also lower than those found in the wild type. Therefore, besides the two proteins of the two-component regulatory pair, a third protein, MoxZ, appears to be involved in regulation of methanol dehydrogenase synthesis.
Antioxidant and UV-Blocking Functionalized Poly(Butylene Succinate) Films (2023)

The introduction of a limited number of functional groups on poly(butylene succinate) (PBS) chains by covalent bonding can impart new properties to the polymer without modifying its thermal and mechanical properties. In pursuit of a viable approach to obtain light- and heat-stabilized PBS samples, the nitroxide radical coupling (NRC) reaction between PBS macroradicals and the 3,5-di-tert-butyl-4-hydroxybenzoyl-2,2,6,6-tetramethylpiperidine-1-oxyl radical (BHB-TEMPO), a functionalizing agent bearing a sterically-hindered antioxidant phenol moiety, is here proposed. The reaction was initiated by peroxide and carried out in solution and in a melt. The functionalized materials were characterized by UV-visible spectroscopy (UV-Vis), proton nuclear magnetic resonance (1H-NMR), and size exclusion chromatography (SEC) analysis to gain structural information and by thermal gravimetric analysis (TGA) and differential scanning calorimetry (DSC) to investigate the thermal properties. In addition, films of the samples were subjected to thermal and photo-oxidative aging to assess their resistance to degradative processes. Finally, the PBS film with the highest degree of functionalization showed the ability to protect β-carotene, a molecule found in food and drugs and that is very sensitive to UV light, from degradation. This result suggests the use of this material (either alone or blended with other biopolyesters) for biodegradable and compostable active packaging.
The Protective Role of Vitamin C on Endothelial Dysfunction (2003)

A major function of endothelium is the secretory control of smooth muscle vascular tone. The principal vasodilator substance excreted is nitric oxide (NO), a molecule that is under thorough investigation. There is sufficient evidence that its bioavailability is reduced in many diseases such as coronary artery disease, heart failure, dyslipidaemias, obesity, diabetes, renal failure, and others. The interactions of this molecule with reactive oxygen species are believed to constitute an important pathophysiological pathway. Consequently, intensive research is under way to evaluate the efficacy of various antioxidant interventions against endothelial dysfunction. Vitamin C is an outstanding hydrophilic antioxidant, which is able to scavenge many reactive oxygen species. When infused or chronically ingested in pharmacological doses it substantially improves the defective endothelium-dependent vasodilation involved in the above-mentioned clinical conditions. Several molecular mechanisms have been proposed for this protective effect including scavenging of superoxide anion, inhibition of LDL-oxidation, inhibition of inflammatory cell adhesion, stabilization of NO-synthase through reduction of tetrahydrobiopterin, NO-release from plasma nitrosothiols and preservation of guanyl cyclase activity. Although the experimental evidence is promising, further human clinical trials are necessary before preventive and therapeutic interventions using vitamin C become an established clinical practice. J Clin Basic Cardiol 2003; 6: 3–6.