gebhart/patrepeval huggingface dataset:
Nitrite anion stimulates ischemic arteriogenesis involving NO metabolism (2012)

Nitric oxide (NO) is a potential regulator of ischemic vascular remodeling, and as such therapies augmenting its bioavailability may be useful for the treatment of ischemic tissue diseases. Here we examine the effect of administering the NO prodrug sodium nitrite on arteriogenesis activity during established tissue ischemia. Chronic hindlimb ischemia was induced by permanent unilateral femoral artery and vein ligation. Five days postligation; animals were randomized to control PBS or sodium nitrite (165 μg/kg) therapy twice daily. In situ vascular remodeling was measured longitudinally using SPY angiography and Microfil vascular casting. Delayed sodium nitrite therapy rapidly increased ischemic limb arterial vessel diameter and branching in a NO-dependent manner. SPY imaging angiography over time showed that nitrite therapy enhanced ischemic gracillis collateral vessel formation from the profunda femoris to the saphenous artery. Immunofluorescent staining of smooth muscle cell actin also confirmed that sodium nitrite therapy increased arteriogenesis in a NO-dependent manner. The NO prodrug sodium nitrite significantly increases arteriogenesis and reperfusion of established severe chronic tissue ischemia.
Glycopeptides derived from glucosaminic acid (2016)

A new class of polymers that resemble a peptidic backbone with pendant sugar side chains.
Chiral separation of calcium channel antagonists by SFC and HPLC using different immobilized chiral stationary phases (2022)

Supercritical fluid chromatography and high-performance liquid chromatography techniques are popular for the chiral separations of different drugs and pharmaceuticals. Therefore, this article describes a comparative study of the chiral separation of some calcium channel antagonists such as verapamil, gallopamil, and nisoldipine. The columns used were Chiralpak IG and Chiralpak ID (250 mm × 4.6 mm, 5.0 μm). The separation was achieved by using a variety of mobile phases in both techniques. The retention, separation, and resolution factors in SFC were in the range of 1.36-7.30, 1.09-1.72, and 1.16-3.47, while these values in the case of HPLC were 1.03-2.42, 1.12-1.35, and 0.49-2.46. The complete resolution of gallopamil and verapamil was achieved successfully. The chiral recognition was controlled by hydrogen bondings, π-π interactions, dipole induced dipole interactions, van der Waal forces, and steric effects. SFC was found to be a better technique than HPLC because of quick separation, good separation power, economic, environment-friendly, and green technology.
Colonic blood flow responses in experimental colitis: time course and underlying mechanisms (2005)

Human inflammatory bowel diseases (IBD) are associated with significant alterations in intestinal blood flow, the direction and magnitude of which change with disease progression. The objectives of this study were to determine the time course of changes in colonic blood perfusion that occur during the development of dextran-sodium-sulfate (DSS)-induced colonic inflammation and to address the mechanisms that may underlie these changes in blood flow. Intravital microscopy was used to quantify blood flow (from measurements of vessel diameter and red blood cell velocity) in different-sized submucosal arterioles of control and inflamed colons in wild-type (WT) mice. A significant (18-30%) reduction in blood flow was noted in the smallest arterioles (<40 microm diameter) on days 4-6 of DSS colitis. The arteriolar responses to bradykinin in control and DSS-treated WT mice revealed an impaired endothelium-dependent, but not endothelium-independent, vasodilation in the inflamed colon. However, this impaired vasodilatory response to bradykinin after DSS treatment was not evident in mutant mice that overexpress Cu,Zn-superoxide dismutase. Rescue of the bradykinin-induced vasodilation during DSS colitis was also observed in mice that are genetically deficient in the NAD(P)H oxidase subunit gp91(phox). These findings indicate that the decline in blood flow during experimental colitis may result from a diminished capacity of colonic arterioles to respond to endogenous endothelium-dependent vasodilators like bradykinin and that NAD(P)H oxidase-derived superoxide plays a major role in the induction of the inflammation-induced endothelium-dependent arteriolar dysfunction.
Vacancy defects in as-grown and neutron irradiated GaP studied by positrons (1986)

Positron lifetime and Doppler-broadening measurements have been used to study vacancy defects in n-type GaP. Vacancies in the P sublattice with a concentration of some 1017 cm−3 were observed in as-grwon GaP. The vacancies disappear during annealing at 500–800 °C. In neutron-irradiated GaP positrons are trapped by Ga vacancies which anneal out in two stages situated at 300–550 °C and 550–700 °C.
Evaluation of restitution slopes using a quasi-stationary exercise protocol (2010)

Cardiac electrical restitution is an important tool for evaluating risk of cardiac arrhythmias. Restitution slopes are used to quantify the rates of QT and DI (diastolic) interval adaptation in response to abrupt changes in cardiac cycle or RR intervals. These slopes can be either measured experimentally using invasive stepwise pacing procedures or assessed clinically from surface ECG. However, acquiring restitution slopes from surface ECG recordings may be complicated due to the presence of significant variations in QT and DI intervals. In this paper, we suggest a novel signal processing method, which overcomes these difficulties by implementing quasi-stationary exercise testing with modulated beat-to-beat QT/DI interval variations.
UROLITHIASIS, ENDOUROLOGY AND LAPAROSCOPIC SURGERY (2000)

No AccessJournal of UrologyUROLOGICAL SURVEY: ABSTRACTS1 May 2000UROLITHIASIS, ENDOUROLOGY AND LAPAROSCOPIC SURGERY Ralph V. ClaymanM.D. Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)67689-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail References 1 : Is stent placement following ureteroscopy for stone removal necessary?. J Urol1999; 159: 59. abstract 218. Google Scholar 2 : Early results of a prospective randomized controlled trial comparing stented versus non-stented ureteroscopic lithotripsy. J Urol1999; 161: 371. abstract 1438. Crossref, Google Scholar 1 : The “mini-perc” technique: a less invasive alternative to percutaneous nephrolithotomy. J Urol1999; 161: 372. abstract 1441. Google Scholar 2 : Mini-percutaneous nephrolitotomy: extended experience and follow-up. J Endourol1999; 13: A38. Google Scholar 3 : Irrigating fluid absorption during percutaneous nephrolithotripsy. Acta Anaesthesiol Scand1999; 43: 316. Google Scholar 1 : Variation in incidence of indinavir-associated nephrolithiasis among HIV-positive patients. AIDS1998; 12: 2433. Google Scholar © 2000 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 163Issue 5May 2000Page: 1614-1621 Advertisement Copyright & Permissions© 2000 by American Urological Association, Inc.MetricsAuthor Information Ralph V. Clayman More articles by this author Expand All Advertisement PDF downloadLoading ...
A coupled finite element/meshfreemoving boundary method for self-piercing riveting simulation (2013)

The use of lightweight materials has been steadily increasing in the automotive industry, and presents new challenges to material joining. Among many joining processes, self-piercing riveting (SPR) is particularly promising for joining lightweight materials (such as aluminum alloys) and dissimilar materials (such as steel to Al, and metal to polymer). However, to establish a process window for optimal joint performance, it often requires a long trial-and-error testing of the SPR process. This is because current state of the art in numerical analysis still cannot effectively resolve the problems of severe material distortion and separation in the SPR simulation. This paper presents a coupled meshfree/finite element with a moving boundary algorithm to overcome these numerical difficulties. The simulation results are compared with physical measurements to demonstrate the effectiveness of the present method.
REPOPULATION KINETICS OF INTESTINAL INTRAEPITHELIAL LYMPHOCYTES IN MURINE BONE MARROW RADIATION CHIMERAS (1992)

The kinetics of lymphoid cell repopulation of murine intestinal intraepithelial lymphocytes (IEL) from BM stem cells were studied in F1----parent radiation chimeras and were compared with T cell repopulation of the thymus and the spleen. T cells arising from donor bone marrow were present in the gut epithelium as early as day 5 postreconstitution in radiation chimeras. By day 7 postreconstitution, and at times thereafter, the IEL consisted of 70-95% CD3+ donor bone marrow-derived T cells, most of which were CD8+ cells with variable Thy-1 expression. CD4+8- IEL also were detected between days 7 and 14 postreconstitution; however, the CD4+8+ IEL subset did not appear within the gut epithelium until several weeks later and was followed by a progressive increase in the intensity of CD8 expression on CD4+8+ IEL. Functionally mature T cell receptor gamma/delta + and alpha/beta + IEL were present throughout repopulation of the gut epithelium. In contrast to the IEL, T cells were not detected in the thymus or the spleen until days 14 and 21 postreconstitution, respectively, and evidence of T cell function in the spleen was not detected until day 21 postreconstitution. These findings have implications for human bone marrow transplantation in that they demonstrate that T cell repopulation of the gut epithelium begins prior to T cell repopulation of the thymus and the spleen, and indicate that even in the presence of a thymus some IEL proceed through an extrathymic developmental pathway.
Ru0 or RuII: A Study on Stabilizing the “Activated” Form of Ru-PNP Complexes with Additional Phosphine Ligands in Alcohol Dehydrogenation and Ester Hydrogenation (2020)

The complex Ru-MACHO has been previously shown to undergo uncontrolled degradation subsequent to base-induced dehydrochlorination in the absence of a substrate. In this study, we report that stabilization of the dehydrochlorinated Ru-MACHO with phosphines furnishes complexes whose structures depend on the phosphines employed: while PMe<sub>3</sub> led to the expected octahedral Ru<sup>II</sup> complex, PPh<sub>3</sub> provided access to a trigonal-bipyramidal Ru<sup>0</sup> complex. Because both complexes proved to be active in base-free (de)hydrogenation reactions, thorough quantum-chemical calculations were employed to understand the reaction mechanism. The calculations show that both complexes lead to the same mechanistic scenario after phosphine dissociation and, therefore, only differ energetically in this step. According to the calculations, the typically proposed metal-ligand cooperation mechanism is not the most viable pathway. Instead, a metal-ligand-assisted pathway is preferred. Finally, experiments show that phosphine addition enhances the catalyst's performance in comparison to the PR<sub>3</sub>-free "activated" Ru-MACHO.
Arthroscopic debridement for primary elbow osteoarthritis with and without capsulectomy: a comparative cohort study (2017)

Background Arthroscopic elbow debridement for primary osteoarthritis may be performed with or without a joint capsulectomy. The purpose of this comparative cohort study was to compare range of motion (ROM) and early complications between patients with and without anterior capsulectomy. Methods In total, 110 patients with primary osteoarthritis of the elbow who underwent an arthroscopic debridement for primary osteoarthritis were reviewed with a minimum of 3 months postoperative follow-up. The first group consisted of 51 patients who had a concomitant capsulectomy and the second group consisted of 59 patients who either had a capsulotomy or did not have the capsule addressed. Results There was significantly greater pre-operative stiffness in the group who had an anterior capsulectomy versus those who did not. A greater improvement in arc of ROM occurred in patients who had a concomitant capsulectomy compared to patients without (24° versus 12°) (p &lt; 0.003); however, there were no significant differences in final ROM between groups. There were no statistically significant differences in the incidence of complications between the groups (16% capsulectomy versus 18% no capsulectomy). Conclusions Elbow arthroscopy and debridement for primary elbow osteoarthritis yields satisfactory motion at short-term follow-up with or without a capsulectomy. The incidence of early complications was low at this tertiary referral centre, with no significant differences between groups.
Clinical Outcomes and Survivorship of Contemporary Cementless Primary Total Knee Arthroplasties (2020)

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Magnesium nitrate attenuates blood pressure rise in SHR rats (2014)

The administration of magnesium supplements and nitrates/nitrites decreases arterial blood pressure and attenuates the development of hypertension-induced complications. This study was performed to examine the effects of treatment with magnesium nitrate on the development of hypertension and its complications in spontaneously hypertensive (SHR) rats. Male SHR rats with persistent hypertension at the age of 12-13 weeks were allocated to two groups according to their arterial blood pressure. Rats from the control group received purified water, while the experimental animals from the second group received magnesium nitrate dissolved in purified water at a dose of 50 mg/kg. After four weeks of treatment, blood pressure was measured, the anatomical and functional parameters of the heart were recorded using an ultrasonograph, vascular reactivity was assayed in organ bath experiments and the cardioprotective effects of magnesium nitrate administration was assayed in an ex vivo experimental heart infarction model. Treatment with magnesium nitrate significantly increased the nitrate concentration in the plasma (from 62 ± 8 μmol/l to 111 ± 8 μmol/L), and attenuated the increase in the arterial blood pressure. In the control and magnesium nitrate groups, the blood pressure rose by 21 ± 3 mmHg and 6 ± 4 mmHg, respectively. The administration of magnesium nitrate had no effect on the altered vasoreactivity, heart function or the size of the heart infarction. In conclusion, our results demonstrate that magnesium nitrate effectively attenuates the rise in arterial blood pressure. However, a longer period of administration or earlier onset of treatment might be needed to delay the development of complications due to hypertension.
1/f Noise Modelling and Characterization for CMOS Quanta Image Sensors (2019)

This work fits the measured in-pixel source-follower noise in a CMOS Quanta Image Sensor (QIS) prototype chip using physics-based 1/<i>f</i> noise models, rather than the widely-used fitting model for analog designers. This paper discusses the different origins of 1/<i>f</i> noise in QIS devices and includes correlated double sampling (CDS). The modelling results based on the Hooge mobility fluctuation, which uses one adjustable parameter, match the experimental measurements, including the variation in noise from room temperature to -70 °C. This work provides useful information for the implementation of QIS in scientific applications and suggests that even lower read noise is attainable by further cooling and may be applicable to other CMOS analog circuits and CMOS image sensors.
Compact VNIR snapshot multispectral airborne system and integration with drone system (2022)

Multispectral imaging technology analyzes for each pixel a wide spectrum of light and provides more spectral information compared to traditional RGB images. Most current Unmanned Aerial Vehicles (UAV) camera systems are limited by the number of spectral bands (≤10 bands) and are usually not fully integrated with the ground controller to provide a live view of the spectral data. We have developed a compact multispectral camera system which has two CMV2K 4x4 snapshot mosaic sensors internally, providing 31 bands in total covering the visible and near-infrared spectral range (460-860nm). It is compatible with (but not limited to) the DJI M600 and can be easily mounted to the drone. Our system is fully integrated with the drone, providing stable and consistent communication between the flight controller, the drone/UAV, and our camera payload. With our camera control application on an Android tablet connected to the flight controller, users can easily control the camera system with a live view of the data and many useful information including histogram, sensor temperature, etc. The system acquires images at a maximum framerate of 2x20 fps and saves them on an internal storage of 1T Byte. The GPS data from the drone is logged with our system automatically. After the flight, data can be easily transferred to an external hard disk. Then the data can be visualized and processed using our software into single multispectral cubes and one stitched multispectral cube with a data quality report and a stitching report.
Hollow filler based mixed matrix membranes (2010)

Micron-sized hollow spheres with zeolitic shell were used as inorganic fillers in PDMS-based mixed matrix membranes, overall enhancing solvent permeabilities as compared to traditional zeolite fillers, while selectivities were maintained.
Biphasic intracellular expression of Staphylococcus aureus virulence factors and evidence for Agr‐mediated diffusion sensing (2003)

Staphylococcus aureus invades a variety of mammalian cells and escapes from the endosome to multiply in the cytoplasm. We had previously hypothesized that the molecular events leading to escape of S. aureus from the endosome involved the Agr virulence factor regulatory system. In this report we demonstrate that temporal changes in intracellular activation of the Agr regulon correlates with expression of membrane active toxins. Also, the initial expression of Agr by even small numbers of staphylococci resulted in the permeabilization of the endosomal membrane and the eventual escape of bacteria into the cytoplasm by 3 h post invasion. After Agr downregulation, a second peak of expression coincided with increased permeability of the host cell membrane. In contrast to the parental strain, an Agr-mutant was unable to escape into the cytoplasm and was observed in intact endosomes as late as 5 h post invasion. These data provide evidence that staphylococcal virulence factor production during invasion of host cells is mediated by an Agr-dependent process that is most accurately described in the context of diffusion sensing.
On Influential Node Discovery in Dynamic Social Networks (2012)

The problem of maximizing influence spread has been widely studied in social networks, because of its tremendous number of applications in determining critical points in a social network for information dissemination. All the techniques proposed in the literature are inherently static in nature, which are designed for social networks with a fixed set of links. However, many forms of social interactions are transient in nature, with relatively short periods of interaction. Any influence spread may happen only during the period of interaction, and the probability of spread is a function of the corresponding interaction time. Furthermore, such interactions are quite fluid and evolving, as a result of which the topology of the underlying network may change rapidly, as new interactions form and others terminate. In such cases, it may be desirable to determine the influential nodes based on the dynamic interaction patterns. Alternatively, one may wish to discover the most likely starting points for a given infection pattern. We will propose methods which can be used both for optimization of information spread, as well as the backward tracing of the source of influence spread. We will present experimental results illustrating the effectiveness of our approach on a number of real data sets.
Significant improvement in recurrence-free survival (RFS) when capecitabine (X) is integrated into docetaxel (T) → 5-FU + epirubicin + cyclophosphamide (CEF) adjuvant therapy for high-risk early breast cancer (BC): interim analysis of the FinXX-trial. (2009)

Abstract Abstract #82 Background: Adding X to T extends survival in patients (pts) with metastatic BC. The primary objective of the FinXX-trial is to compare RFS with XT→CEX vs. T→CEF as adjuvant therapy in pts with early BC. Secondary objectives are comparison of overall survival, distant RFS and safety. Methods: Between Jan 2004 and May 2007, 1500 pts were randomized to receive T x 3 → CEF x 3 (T 80mg/m² d1 → C 600mg/m² d1, E 75mg/m² d1, F 600mg/m² d1, q3 wks) or XT x 3 → CEX x 3 (T 60mg/m² d1 + X 900mg/m² bid d1–15 → C 600mg/m² d1, E 75mg/m² d1, X 900mg/m² bid d115, q3 wks). Results: 1496 pts were included in the ITT analysis (two pts withdrew consent, two had metastatic disease). The study population represented a high-risk group (90% node positive, 19% HER2 positive, 88% poorly or moderately differentiated tumors). The baseline characteristics were well balanced in the two treatment arms. After median follow-up of 3 years, there have been 134 events (deaths, distant or local relapses; Table). The significantly improved RFS rate was achieved despite a higher number of study treatment discontinuations in the X-containing arm (178 vs. 23 pts in the control arm; when XT was discontinued, the remaining XT cycles were replaced with an equal number of T cycles, and CEX cycles with CEF cycles). 75% of pts in the X-containing arm received all six planned cycles of therapy compared with 96% in the control arm. The adverse effect profiles of XT→CEX and T→CEF were in part different (Gr. 3/4 neutropenic fever/infection 10.0% vs. 20.2%, hand-foot syndrome 11.1% vs. 0.3%, diarrhea 6.2% vs. 3.4%, stomatitis 4.2% vs. 1.6%, myalgia 1.9% vs. 8.0%, respectively).&amp;#x2028; &amp;#x2028; Conclusions: The primary endpoint of this trial, to demonstrate a significant improvement in RFS, was achieved after median follow-up of 3 years. The hazard ratio of 0.66 (95% CI 0.47–0.94; p=0.020) for RFS translates into a 34% reduction in the rate of recurrences or deaths in pts receiving XT→CEX. This significant benefit was seen using an X dose of 900 mg/m² bid, and with a lower T dose in the XT arm than with T monotherapy. Overall survival data are not yet mature but a trend towards improvement (hazard ratio 0.66 [95% CI 0.401.07]; p=0.089) can be seen in the XT→CEX arm. The results suggest that the risk of breast cancer recurrence can be reduced substantially with integration of capecitabine into a taxane-/anthracycline-based regimen. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 82.
Perspective of Botox for treatment of male lower urinary tract symptoms (2008)

Although the clinical series demonstrate efficacy of minimum 6 months, more studies are necessary in order to identify the mechanisms by which BTX-A affects the prostate, the ideal dose and the duration of effect. BTX-A use in prostate disease is currently 'off-label'.