gebhart/patrepeval huggingface dataset:
Assembly of nuclear pore complexes and annulate lamellae promotes normal pronuclear development in fertilized mammalian oocytes (1998)

ABSTRACT In addition to functional nuclear pore complexes engaged in nucleo-cytoplasmic transport, the cytoplasmic stacks of pore complexes, called annulate lamellae, exist in numerous cell types. Although both annulate lamellae and nuclear pore complexes are present in fertilized mammalian oocytes, their relative roles in the process of fertilization and preimplantation development are not known. Using epifluorescence and electron microscopy, we explored their fate during bovine fertilization. The assembly of annulate lamellae in bovine oocytes was triggered by sperm-oocyte binding and continued concomitantly with the incorporation of the nuclear pores in the nuclear envelopes of the developing male and female pronuclei. This process was also induced by the parthenogenetic activation of metaphase-II-arrested oocytes. Depletion of Ca2+, previously implicated in oocyte activation and in the insertion of pore complexes into the nuclear envelope, prevented the formation of nuclear pore complexes, but not the assembly of annulate lamellae in oocyte cytoplasm. Injection of the nuclear pore antagonist, wheat germ agglutinin, into the cytoplasm of mature oocytes that were subsequently fertilized caused the arrest of pronuclear development, indicating the requirement of nuclear pore complexes for normal pronuclear development. Treatment of the fertilized oocytes with the microtubule inhibitor, nocodazole, prevented gathering of annulate lamellae around the developing pronuclei, insertion of nuclear pores into their nuclear envelopes, and further pronuclear development. The formation of the male pronuclei was reconstituted in Xenopus egg extracts and reflected the behavior of nuclear pores during natural fertilization. These data suggest that nuclear pore complexes are required for normal pronuclear development from its beginning up until pronuclear apposition. Annulate lamellae may be involved in the turnover of nuclear pore complexes during fertilization, which is in turn facilitated by the reorganization of oocyte microtubules and influx of Ca2+ into oocyte cytoplasm.
Recognition of a B cell leukemia-associated minor histocompatibility antigen by CTL (1997)

CTL directed against minor histocompatibility Ags (mHag) play a major role in antileukemia reactivity after HLA-identical bone marrow transplantation. Some of these mHag are restricted to hemopoietic cells, others show a broad tissue expression. Therefore, antileukemia reactivity is often associated with graft-vs-host disease. Here, we report the identification of a B cell leukemia-associated mHag, HB-1, recognized by a CD8+ CTL clone derived from peripheral blood of an acute lymphoblastic B cell leukemia patient who has been treated by HLA-matched bone marrow transplantation. Interestingly, the CTL clone that recognizes HB-1 exhibits specific cytotoxicity toward leukemic as well as EBV-transformed B cells, but not against untransformed B cells. Moreover, the CTL clone does not lyse PHA-stimulated T cell blasts, monocytes, and fibroblasts, indicating that HB-1 is mainly expressed by transformed B cells. Further analysis reveals that HB-1 is restricted by HLA-B44 (both B*4402 and B*4403) and that 28% of HLA-B44-positive individuals express HB-1. These findings demonstrate that leukemia-associated mHag with a restricted tissue distribution, such as HB-1, elicit CTL reactivity in vivo. These Ags are of potential use in immunotherapy against leukemia because they generate antileukemia reactivity that is not associated with graft-vs-host disease.
Metabolic costs and evolutionary implications of human brain development (2014)

The high energetic costs of human brain development have been hypothesized to explain distinctive human traits, including exceptionally slow and protracted preadult growth. Although widely assumed to constrain life-history evolution, the metabolic requirements of the growing human brain are unknown. We combined previously collected PET and MRI data to calculate the human brain's glucose use from birth to adulthood, which we compare with body growth rate. We evaluate the strength of brain-body metabolic trade-offs using the ratios of brain glucose uptake to the body's resting metabolic rate (RMR) and daily energy requirements (DER) expressed in glucose-gram equivalents (glucosermr% and glucoseder%). We find that glucosermr% and glucoseder% do not peak at birth (52.5% and 59.8% of RMR, or 35.4% and 38.7% of DER, for males and females, respectively), when relative brain size is largest, but rather in childhood (66.3% and 65.0% of RMR and 43.3% and 43.8% of DER). Body-weight growth (dw/dt) and both glucosermr% and glucoseder% are strongly, inversely related: soon after birth, increases in brain glucose demand are accompanied by proportionate decreases in dw/dt. Ages of peak brain glucose demand and lowest dw/dt co-occur and subsequent developmental declines in brain metabolism are matched by proportionate increases in dw/dt until puberty. The finding that human brain glucose demands peak during childhood, and evidence that brain metabolism and body growth rate covary inversely across development, support the hypothesis that the high costs of human brain development require compensatory slowing of body growth rate.
Additions and Corrections. Metal Atom Matrix Chemistry. Correlation of Bonding with Chemisorbed Molecules (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleAdditions and Corrections. Metal Atom Matrix Chemistry. Correlation of Bonding with Chemisorbed MoleculesGeoffrey OzinCite this: Acc. Chem. Res. 1977, 10, 12, 455Publication Date (Print):December 1, 1977Publication History Published online1 May 2002Published inissue 1 December 1977https://pubs.acs.org/doi/10.1021/ar50120a005https://doi.org/10.1021/ar50120a005research-articleACS PublicationsRequest reuse permissionsArticle Views35Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Table ST3 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma (2023)

&lt;p&gt;Table ST3: Differential expressed RNA transcripts between MEKi-sensitive and -resistant melanoma cell cultures.&lt;/p&gt;
The Underlying Mechanism of Preventing Facial Nerve Stimulation by Triphasic Pulse Stimulation in Cochlear Implant Users Assessed With Objective Measure (2016)

Triphasic pulse stimulation prevents from FNS because of a smaller gradient of EMG input-output function compared with biphasic pulse stimulation. The underlying mechanism can be modeled by differences in spatiotemporal spread of the electrical field.
A Framework for Dynamic Web Services Composition (2007)

Abstract. Dynamic composition of web services is a promising approach and at the same time a challenging research area for the dissemination of serviceoriented applications. It is widely recognised that service semantics is a key element for the dynamic composition of Web services, since it allows the unambiguous descriptions of a service’s capabilities and parameters. This paper introduces a framework for performing dynamic service composition by exploiting the semantic matchmaking between service parameters (i.e., outputs and inputs) to enable their interconnection and interaction. The basic assumption of the framework is that matchmaking enables finding semantic compatibilities among independently defined service descriptions. We also developed a composition algorithm that follows a semantic graph-based approach, in which a graph represents service compositions and the nodes of this graph represent semantic connections between services. Moreover, functional and non-functional properties of services are considered, to enable the computation of relevant and most suitable service compositions for some service request. The suggested end-to-end functional level service composition framework is illustrated with a realistic application scenario from the IST SPICE project. 1
Structure and effective pore size of the dehydrated forms of the molecular sieve VPI-5 (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure and effective pore size of the dehydrated forms of the molecular sieve VPI-5Johan A. Martens, Eddy Feijen, Jan L. Lievens, Piet J. Grobet, and Peter A. JacobsCite this: J. Phys. Chem. 1991, 95, 24, 10025–10031Publication Date (Print):November 1, 1991Publication History Published online1 May 2002Published inissue 1 November 1991https://pubs.acs.org/doi/10.1021/j100177a076https://doi.org/10.1021/j100177a076research-articleACS PublicationsRequest reuse permissionsArticle Views132Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Integration of a Traveling-Wave Electro-Absorption Modulator with a Widely Tunable SG-DBR Laser (2007)

A widely tunable transmitter integrating a sampled grating DBR laser and traveling wave EAM with on-chip termination is presented. The transmitter exhibits a 23 GHz bandwidth, greater than 1 mW output power, and wavelength tuning over 30 nm.
The impact of immobilization of BMP‐2 on PDO membrane for bone regeneration (2012)

Poly(dioxanone) (PDO) is colorless, crystalline, a biodegradable synthetic polymers that is used for biomedical applications, such as surgical sutures, cardiovascular applications, orthopedics, and plastic surgery. Recently, bone morphogenetic protein-2 (BMP-2) is widely used for bone tissue engineering. For the first time we report here on the in vitro performance of an electrospun PDO membrane immobilized with BMP-2. Immobilized BMP-2 on PDO membrane enhanced ALPase activity, the osteogenic differentiation gene expressions as well as cell attachment, except cell proliferation when compared to that of PDO membrane alone. These results suggest that PDO membrane with BMP-2 is helpful to promote bone healing and regeneration.
Gamma-valerolactone biorefinery: Catalyzed birch fractionation and valorization of pulping streams with solvent recovery (2023)

In this study, we propose a full gamma-valerolactone (GVL) organosolv biorefinery concept including the utilization of all pulping streams, solvent recovery, and preliminary material and energy balances. GVL is a renewable and non-toxic solvent that fractionates woody biomass. The silver birch chips were pulped (45-65 wt% GVL, 150 °C, 2 h) under a series of acid-catalyzed conditions (5-12 kg H<sub>2</sub>SO<sub>4</sub>/t), and the fully bleached pulp was spun into fibers by the IONCELL® process and knitted into the fabric. The dissolved lignin was precipitated by water from spent liquor (1:1) and processed into polyhydroxyurethane. Most of the dissolved hemicelluloses were in the form of xylose, therefore, the crystallization efficiency of xylose from spent liquor in the presence of residual GVL was studied. The GVL recovery rate in the lab column was 66%, however by increasing the number of equilibrium stages, 99% recovery could be achieved.
Controlled Release from Model Blend Multilayer Films Containing Mixtures of Strong and Weak Polyelectrolytes (2012)

We have designed the controlled release platforms based on polyelectrolyte (PE) blend multilayer films to investigate the release mode and kinetics at the nanoscale level. The model blend multilayer films are composed of positively charged layers with weak polyelectrolytes (PEs) (linear poly(ethylenimine), LPEI) and negatively charged blend layers with mixtures of strong (poly(sodium 4-styrenesulfonic acid), PSS) and weak (poly(methacrylic acid), PMAA) PEs. The blend multilayer films ([LPEI/PSS:PMAA]n) with well-defined internal structure were prepared by the spin-assisted layer-by-layer (LbL) deposition method. Release properties of the multilayer films were systematically studied as a function of blend ratio by neutron reflectivity (NR), ellipsometer, AFM, FT-IR spectroscopy, and quartz crystal microbalance with dissipation (QCM-D). Since PSS strong PEs serve as robust skeletons within the multilayer films independent of external pH variation, the burst disruption of pure weak PE multilayer films was dramatically suppressed, and the release kinetics could be accurately controlled by simply changing the PSS content within the blend films. These release properties of blend multilayer films form the basis for designing the controlled release of target active materials from surfaces.
<title>Model building, control design and practical implementation of a high precision high dynamical MEMS acceleration sensor (Invited Paper)</title> (2005)

This paper presents the whole process of building up a high precision, high dynamical MEMS acceleration sensor. The first samples have achieved a resolution of better than 500 ug and a bandwidth of more than 200 Hz. The sensor fabrication technology is shortly covered in the paper. A theoretical model is built from the physical principles of the complete sensor system, consisting of the MEMS sensor, the charge amplifier and the PWM driver for the sensor element. The mathematical modeling also covers problems during startup. A reduced order model of the entire system is used to design a robust control with the Mixed-Sensitivity H-infinity Approach. Since the system has an unstable pole, imposed by the electrostatic field and time delay, caused by A/D-D/A conversation delay and DSP computing time, limitations for the control design are given. The theoretical model might be inaccurate or lacks of completeness, because the parameters for the theoretical model building vary from sample to sample or might be not known. A new identification scheme for open or closed-loop operation is deployed to obtain directly from the samples the parameters of the mechanical system and the voltage dependent gains. The focus of this paper is the complete system development and identification process including practical tests in a DSP TI-TMS320C3000 environment.
Production of a Raw Starch Saccharifying Enzyme byCorticium rolfsii (1986)

Corticium rolfsii AHU 9627, which we isolated from a tomato stem, is one of the most promising producers of a raw starch saccharifying enzyme. The effects of the cultural conditions and medium components on the enzyme production were investigated. The enzyme production was improved by increasing both the concentrations of carbon sources and organic nutrients in the medium. Under the optimum cultural conditions, the enzyme activity of the culture supernatant against raw starch reached a maximum after 8-days incubation at 27°C and the activity reached 80 units per ml (when determined at 40°C and pH 4.0). The optimal pH and temperature for the enzyme reaction were 4.0 and 65°C, respectively. The saccharifying reaction was scarcely inhibited even with a high substrate concentration, and raw starch was rapidly hydrolyzed into glucose.
Real-time Color Ball Tracking for Augmented Reality (2008)

In this paper, we introduce a light-weight and robust tracking technique based on color balls. The algorithm builds on a variant of randomized Hough transform and is optimized for a use in real-time applications like on low-cost Augmented Reality (AR) systems. With just one conventional color camera our approach provides the ability to determine the 3D position of several color balls at interactive frame rates on a common PC workstation. It is fast enough to be easily combined with another real-time tracking engine. In contrast to popular tracking techniques based on recognition of planar fiducial markers it offers robustness to partial occlusion, which eases handling and manipulation. Furthermore, while using balls as markers a proper haptic feedback and visual metaphor is provided. The exemplary use of our technique in the context of two AR applications indicates the effectiveness of the proposed approach.
Synthesis of V, Pt and Pt-V colloidal nanoparticles (2013)

Bimetallic platinum-vanadium nanoparticles have been successfully synthesised by high temperature thermal decomposition of metal precursor salts. Vanadium is a highly reactive metal and poses considerable difficulty in synthesising metallic nanoparticles, while platinum has low reactivity where nanoparticles are easily synthesised. The difficulties associated with the reduction of vanadium salt were circumvented by the use of high boiling point solvents and selected surfactants. Co-reduction using platinum precursors compatible with the high temperature processes was required for bimetallic nanoparticle synthesis. The chemical synthesis route described is novel, robust and highly reproducible. Microstructural characterisation of nanoparticles synthesised as described, using transmission electron microscopy, reveals single-crystal particles.
Dung biomass smoke activates inflammatory signaling pathways in human small airway epithelial cells (2016)

Animal dung is a biomass fuel burned by vulnerable populations who cannot afford cleaner sources of energy, such as wood and gas, for cooking and heating their homes. Exposure to biomass smoke is the leading environmental risk for mortality, with over 4,000,000 deaths each year worldwide attributed to indoor air pollution from biomass smoke. Biomass smoke inhalation is epidemiologically associated with pulmonary diseases, including chronic obstructive pulmonary disease (COPD), lung cancer, and respiratory infections, especially in low and middle-income countries. Yet, few studies have examined the mechanisms of dung biomass smoke-induced inflammatory responses in human lung cells. Here, we tested the hypothesis that dung biomass smoke causes inflammatory responses in human lung cells through signaling pathways involved in acute and chronic lung inflammation. Primary human small airway epithelial cells (SAECs) were exposed to dung smoke at the air-liquid interface using a newly developed, automated, and reproducible dung biomass smoke generation system. The examination of inflammatory signaling showed that dung biomass smoke increased the production of several proinflammatory cytokines and enzymes in SAECs through activation of the activator protein (AP)-1 and arylhydrocarbon receptor (AhR) but not nuclear factor-κB (NF-κB) pathways. We propose that the inflammatory responses of lung cells exposed to dung biomass smoke contribute to the development of respiratory diseases.
The Mathews legacy on the $100 Laptop (2007)

The Mathews Music 4 program was the inspiration for a series of audio-processing languages by this author: Music 360 (1968), Music 11 (1973), Csound (1985), XTCsound (1997), and CsoundXO (2007). Instruments modeled in any one of these systems will run almost unmodified in any other, a testament to the long reach of Max’s original concepts. But Max’s longest reach is yet to come, for CsoundXO has been developed for the $100 Laptop—a machine designed by One Laptop Per Child (OLPC) which aims to put a laptop in the hands of every child on the planet (www.laptop.org). These machines are mesh-networked so that a child in one village can connect to a child in a neighboring village, and so on, until an international access point is reached. But CsoundXO on each machine is also designed for collaborative performance, so that a child in one country can ‘‘share’’ his/her original composition with a child in a similar or different culture. And if the work is interactive, each child can perform collaboratively with others who may be near or far. This paper will describe how all this works, along with a live demonstration.
Measurement of electrical avalanches and optical radiation near solid insulators in high pressure (up to 0.3 MPa) nitrogen gas (1991)

Electron and ion avalanches have been recorded near a variety of insulators (plexiglas, teflon, high-density polyethylene, low-density polyethylene, polypropylene, delrin, polyvinyl chloride, and nylon) in nitrogen gas at pressures of 0.1, 0.2, and 0.3 MPa. With the exception of nylon, suppression of avalanches has been observed in the presence of insulators. In addition to electron and ion avalanches, simultaneous measurement of optical radiation associated with an electron avalanche was successfully carried out. Qualitative explanations have been provided for the suppression of avalanches near most insulators and an anomalous growth of avalanches near nylon insulators. Photoemission from nylon surfaces appears to be responsible for the enhanced growth of avalanches near nylon insulators. More precise measurements of optical radiation are needed to better understand the electron-photon interactions near a solid insulator in a gaseous dielectric medium.
Fast 2D Inversion for Enhanced Real-Time Reservoir Mapping While Drilling (2016)

Abstract The new reservoir mapping-while-drilling technology provides enough data so that a real-time reservoir map can be created through inversion for a layered medium. These reservoir maps are used to optimize well placement and to improve reservoir understanding. Complex reservoirs can be imaged, but the assumption of a layered medium loses its validity when the reservoir cannot be approximated using 1D model locally, i.e., when the reservoir structure varies on the scale of the tool spacing. To improve reservoir mapping performance in such scenarios, an unbiased approximate 2D inversion is introduced that minimizes the error to the layer medium approximation of the reservoir. It is suited for any mildly 2D scenario in which the reservoir does not change abruptly. The method is validated on synthetic and field datasets.