gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Bioactive Phenylethanoids and Coumarines from Basalmocitrus cameroonensis. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Gingipains of Porphyromonas gingivalis Affect the Stability and Function of Serine Protease Inhibitor of Kazal-type 6 (SPINK6), a Tissue Inhibitor of Human Kallikreins (2016)

Periodontitis, a chronic inflammation driven by dysbiotic subgingival bacterial flora, is linked on clinical levels to the development of a number of systemic diseases and to the development of oral and gastric tract tumors. A key pathogen, Porphyromonas gingivalis, secretes gingipains, cysteine proteases implicated as the main factors in the development of periodontitis. Here we hypothesize that gingipains may be linked to systemic pathologies through the deregulation of kallikrein-like proteinase (KLK) family members. KLKs are implicated in cancer development and are clinically utilized as tumor progression markers. In tissues, KLK activity is strictly controlled by a limited number of tissue-specific inhibitors, including SPINK6, an inhibitor of these proteases in skin and oral epithelium. Here we identify gingipains as the only P. gingivalis proteases responsible for SPINK6 degradation. We further show that gingipains, even at low nanomolar concentrations, cleaved SPINK6 in concentration- and time-dependent manner. The proteolysis was accompanied by loss of inhibition against KLK13. We also mapped the cleavage by Arg-specific gingipains to the reactive site loop of the SPINK6 inhibitor. Moreover, we identified a significant fraction of SPINK6-sensitive proteases in healthy saliva and confirmed the ability of gingipains to inactivate SPINK6 under ex vivo conditions. Finally, we demonstrate the double-edge action of gingipains, which, in addition, can activate KLKs because of gingipain K-mediated proteolytic processing of the zymogenic proform of KLK13. Altogether, the results indicate the potential of P. gingivalis to disrupt the control system of KLKs, providing a possible mechanistic link between periodontal disease and tumor development.
Uric Acid, Left Ventricular Mass Index, and Risk of Cardiovascular Disease in Essential Hypertension (2005)

Elevated serum uric acid (UA) is frequently encountered in individuals with hypertension, but whether the relationship between UA and cardiovascular events is circumstantial or causal remains to be answered. We examined the association between serum UA and left ventricular mass index (LVMI) and investigated prospectively whether the combination of UA and LVMI can predict the incidence of cardiovascular disease (CVD) in asymptomatic subjects with essential hypertension. A total of 619 subjects (mean age, 61 years; 52% female) free of prior CVD were included in this study. A significant association between UA and LVMI was also confirmed in multiple regression analysis (male: F=4.29, P<0.04; female: F=4.24, P<0.05). During follow-up (mean, 34 months), 28 subjects (14 female) developed CVD including myocardial infarction, angina pectoris, congestive heart failure, cerebral infarction, and transient cerebral ischemia. Sex-specific median values were used to separate the higher group from the lower group of UA and LVMI. Kaplan-Meier curves showed a significantly poorer survival rate in the group with higher UA and LVMI (LVMI, male: >126.9, female: >112.0 g/m2; UA, male: >374.7, female: >303.3 micromol/L; log-rank chi2=13.18; P<0.01). Multivariate Cox regression analysis showed that the combination of higher UA and LVMI was an independent predictor for CVD events (hazard ratio, 2.38; P<0.03). Our findings demonstrate that UA is independently associated with LVMI and suggest that the combination of hyperuricemia combined with left ventricular hypertrophy is an independent and powerful predictor for CVD. The association between UA and CVD events may be introduced in part because of a direct association of UA with LVMI.
Advertising emergency contraception using local radio: an evaluation (1996)

Emergency contraception offers considerable potential for reducing un wanted pregnancies, yet knowledge about its availability and use remains poor. This paper describes a radio advertising campaign in Rotherham and surrounding areas to promote the use of emergency contraception. The effectiveness of the campaign was evaluated by comparing the prescribing of emergency contraception in the districts participating in the campaign with a control district. It was concluded that the campaign was worthwhile and recommended that this type of initiative is repeated, ensuring that the advertisement is clear and unambiguous and bearing in mind that helplines targeting young people should be available at appropriate times.
A rapid, simple method for the genetic discrimination of intact Arabidopsis thaliana mutant seeds using metabolic profiling by direct analysis in real-time mass spectrometry (2011)

The described DART-MS combined by multivariate analysis allows for rapid screening and metabolic characterization of lots of Arabidopsis mutant seeds without complex metabolic preparation steps. Moreover, potential novel metabolic markers can be detected and used to clarify the genetic relationship between Arabidopsis cultivars. Furthermore this technique can be applied to predict the novel gene function of metabolic mutants regardless of morphological phenotypes.
On-state reliability of solid-electrolyte switch (2008)

We examined the ON-state reliability of a solid electrolyte resistive switch,named ldquoNanoBridgerdquo, for programmable logic application. We found a trade-off between turn-off current and ON-state reliability and optimized the ON conductance. Through this optimization, we obtained high durability against DC current of ~0.2 mA at 105degC for 10 years and low turn-off current less than 5 mA. NanoBridge can thus meet the requirements for programmable logic applications.
ANALYSIS OF FREE AND FORCED VIBRATIONS IN THE TWO-STOREY BUILDING FRAME WITH CRACKS (2023)

Bài báo này phân tích dao động tự do và dao động cưỡng bức của khung nhà 2 tầng có vết nứt. Hệ khung hai tầng có vết nứt được mô hình hóa khi tồn tại nhiều tham số cấu thành như độ sâu vết nứt, vị trí vết nứt, độ cứng uốn và lực đàn hồi tham gia bởi một hàm phi tuyến. Ngoài ra, trong phân tích dao động cưỡng bức, tác dụng của tải trọng ngoài ngẫu nhiên được thực hiện để tìm các đặc trưng xác suất của chuyển vị. Kết quả của phản ứng kết cấu là giá trị bình phương trung bình của chuyển vị, tần số dao động tự nhiên và hàm mật độ xác suất của chuyển vị. Có thể thấy rằng khi các vết nứt xuất hiện ở giữa các cột thì cần phải xem xét kỹ lưỡng nhất bởi vấn đề này sẽ làm cho kết cấu trở nên rất nguy hiểm trong quá trình tồn tại. Các kết quả thu được trong bài báo này có thể được sử dụng trong tính toán thử nghiệm có xét đến ảnh hưởng của nhiều thông số khi phân tích phản ứng của hệ kết cấu.
Inducible Synthetic Growth Regulation Using the ClpXP Proteasome Enhances cis,cis-Muconic Acid and Glycolic Acid Yields in Saccharomyces cerevisiae (2023)

Engineered microbial cells can produce sustainable chemistry, but the production competes for resources with growth. Inducible synthetic control over the resource use would enable fast accumulation of sufficient biomass and then divert the resources to production. We developed inducible synthetic resource-use control over<i>Saccharomyces cerevisiae</i> by expressing a bacterial ClpXP proteasome from an inducible promoter. By individually targeting growth-essential metabolic enzymes Aro1, Hom3, and Acc1 to the ClpXP proteasome, cell growth could be efficiently repressed during cultivation. The ClpXP proteasome was specific to the target proteins, and there was no reduction in the targets when ClpXP was not induced. The inducible growth repression improved product yields from glucose (cis,cis-muconic acid) and per biomass (cis,cis-muconic acid and glycolic acid). The inducible ClpXP proteasome tackles uncertainties in strain optimization by enabling model-guided repression of competing, growth-essential, and metabolic enzymes. Most importantly, it allows improving production without compromising biomass accumulation when uninduced; therefore, it is expected to mitigate strain stability and low productivity challenges.
ChemInform Abstract: Bicyclo[3.2.0]hept‐2‐en‐6‐one Cyanohydrins: Preparations by Chemical Hydrocyanation, and Enantio‐ and Diastereoselective Biotransformation by the Hydroxynitrile Lyase from Prunus amygdalus in the Form of Almond Meal. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Profile of retinal nerve fibre layer symmetry in a multiethnic Asian population: the Singapore Epidemiology of Eye Diseases study (2019)

In non-glaucoma individuals, intereye RNFL profile is less symmetric in Malays and Indians than that in Chinese. This also suggests that current commercial optical coherence tomography's deployment of a single, universal RNFL symmetry cut-off for glaucoma detection is flawed, and ethnic-specific cut-off is warranted.
User Association in 5G mmWave Networks (2017)

The approaching 5G era of cellular communications is posing stringent performance requirements. New groundbreaking applications can be enabled only by means of multi-Gbps data rates and ultra-low latencies. The spectrum scarcity at frequencies below 6 GHz stimulated a new wave of wireless research that focuses on higher bands, namely mmWave. Directionality and high penetration loss represent the key challenges when operating with such carriers. The resulting intermittent connectivity makes the user association problem even more complex and critical than in previous generations of cellular systems, where the channel was better behaved. In this paper, we aim at deriving an optimal and fair cell selection policy that encapsulates the reallocation cost of potential handovers, and captures the erratic nature of the mmWave channel. An important conclusion is that (i) if there is no, or minimal, reallocation cost, each user associates with a single BS, while (ii) for higher handover cost values, users tend to connect to multiple base stations simultaneously.
<title>Beam shape transforming devices in high-efficiency projection systems</title> (1997)

Beam-shape transformers are used in high-efficiency projectors to match round source beams to rectangular LCD targets. Two common alternative approaches use (1) light- pipes and (2) lenslet arrays. Both approaches outperform the simple overfilling used in simpler systems. We review the two approaches conceptually and develop simple theoretical models which elucidate each approach's trade-offs between uniformity, efficiency, etendue, and compactness. For the light-pipe approach, we develop a detailed analytical theory for idealized, uniform sources, and we compare the predictions to ray-trace results. Finally, we compare the two approaches and find that the light-pipe approach offers similar performance with higher compactness. The lens array approach, however, may be favored in complex systems where multiple elements already result in long optical trains, or in systems where etendue conservation is not a priority.
In Silico ADMET Traffic Lights as a Tool for the Prioritization of HTS Hits (2006)

The need for in silico characterization of HTS hit structures as part of a data-driven hit-selection process is demonstrated. A solution is described in the form of an in silico ADMET traffic light and PhysChem scoring system. This has been extensively validated with in-house data at Bayer, published data, and a collection of launched small-molecule oral drugs.
An Optimization Method for Multi-Operator and Mixed-Traffic LTE Deployments in the Unlicensed Bands (2018)

The proliferation of multimedia applications and services increased the demand on data and the requirement by operators to improve the experience of their users. This has motivated the extension of cellular technologies, such as Long Term Evolution (LTE) toward using the unlicensed bands. However, the nature of these bands poses a challenge since there is uncontrolled interference from other coexisting transmissions. We discuss in this paper the issue of efficient coexistence of LTE operators in the unlicensed bands through an optimization framework that is based on performance metrics obtained using stochastic geometry. The proposed optimization framework allows for obtaining optimized network topologies that maximize the benefit of LTE operators looking to deploy their networks in the unlicensed bands.
Biomimetic Polymers for Cardiac Tissue Engineering (2016)

Heart failure is a morbid disorder characterized by progressive cardiomyocyte (CM) dysfunction and death. Interest in cell-based therapies is growing, but sustainability of injected CMs remains a challenge. To mitigate this, we developed an injectable biomimetic Reverse Thermal Gel (RTG) specifically engineered to support long-term CM survival. This RTG biopolymer provided a solution-based delivery vehicle of CMs, which transitioned to a gel-based matrix shortly after reaching body temperature. In this study we tested the suitability of this biopolymer to sustain CM viability. The RTG was biomolecule-functionalized with poly-l-lysine or laminin. Neonatal rat ventricular myocytes (NRVM) and adult rat ventricular myocytes (ARVM) were cultured in plain-RTG and biomolecule-functionalized-RTG both under 3-dimensional (3D) conditions. Traditional 2D biomolecule-coated dishes were used as controls. We found that the RTG-lysine stimulated NRVM to spread and form heart-like functional syncytia. Regarding cell contraction, in both RTG and RTG-lysine, beating cells were recorded after 21 days. Additionally, more than 50% (p value < 0.05; n = 5) viable ARVMs, characterized by a well-defined cardiac phenotype represented by sarcomeric cross-striations, were found in the RTG-laminin after 8 days. These results exhibit the tremendous potential of a minimally invasive CM transplantation through our designed RTG-cell therapy platform.
Effective Passivation of Nanostructured TiO2 Interfaces with PEG-Based Oligomeric Coadsorbents To Improve the Performance of Dye-Sensitized Solar Cells (2012)

A novel poly(ethylene glycol) (PEG) based oligomeric coadsorbent was employed to passivate TiO2 photoanodes resulting in the large increase in both open-circuit voltage (Voc) and short-circuit current density (Jsc) primarily because of the reduced electron recombination by the effective coverage of vacant sites as well as the negative band-edge shift of TiO2. The effective suppression of electron recombination was evidenced by electrochemical impedance spectroscopy (EIS) and by stepped light-induced transient measurements of photocurrent and voltage (SLIM-PCV). The work function measurements also showed that the existence of coadsorbents on TiO2 interfaces is capable of shifting the band-edge of TiO2 photoanodes upwardly resulting in the increase in photovoltage. In addition, the coadsorbent was proven to be effective even in the presence of common additives such as LiI, 4-tert-butylpyridine, and guanidinium thiocyanate. The effect of Li+ cation trapping by ethylene oxide units of the coadsorbent was particularly notable to significantly increase Voc at a small expense of Jsc. Consequently, the introduction of novel PEG-based oligomeric coadsorbents for TiO2 photoanodes is quite effective in the improvement of photovoltaic performance because of the simultaneous increase in both Voc and Jsc.
Towards HBV curative therapies (2018)

Tremendous progress has been made over the last 2 decades to discover and develop approaches to control hepatitis B virus (HBV) infections and to prevent the development of hepatocellular carcinoma using various interferons and small molecules as antiviral agents. However, none of these agents have significant impact on eliminating HBV from infected cells. Currently the emphasis is on silencing or eliminating cccDNA, which could lead to a cure for HBV. Various approaches are being developed including the development of capsid effectors, CRISPR/Cas9, TALENS, siRNA, entry and secretion inhibitors, as well as immunological approaches. It is very likely that a combination of these modalities will need to be employed to successfully eliminate HBV or prevent virus rebound on discontinuation of therapy. In the next 5 years clinical data will emerge which will provide insight on the safety and feasibility of these approaches and if they can be applied to eradicate HBV infections globally. In this review, we summarize current treatments and we highlight and examine recent therapeutic strategies that are currently being evaluated at the preclinical and clinical stage.
Perioperative fluid management in renal transplantation: a narrative review of the literature (2006)

Adequate volume maintenance is essential to prevent acute renal failure during major surgery or to ensure graft function after renal transplantation. The various recommendations on the optimum fluid therapy are based, at best, on sparse evidence only from observational studies. This article reviews the literature on perioperative fluid management in renal transplantation. Crystalloid solutions not exerting any specific side-effects are the first choice for volume replacement in kidney transplantation. The use of colloids should be restricted to patients with severe intravascular volume deficits necessitating high volume restoration. The routine application of albumin, dopamine, and high dose diuretics is no longer warranted. Mannitol given immediately before removal of the vessel clamps reduces the requirement of post-transplant dialysis, but has no effects on graft function in the long term. There is insufficient evidence on the best use of dialysis, but it seems peritoneal dialysis pretransplant is associated with less delayed graft function, whereas the preference of dialysis post-transplant is not yet well-founded. This review article should provide better guidance for fluid management in kidney transplantation until best-evidence guidelines can be established based upon more research.
You Haven't Heard the End of It: Telomere Loss May Link Human Aging with Cancer (1995)

RÉSUMÉ: Des mécanismes moléculaires liant le cancer à la sénescence cellulaire sont présentement explorés. Les télomères (l'extrémité des chromosomes) raccourcissent à chaque division cellulaire et il a été proposé que ce raccourcissement soit l'horloge moléculaire qui déclenche le processus de la sénescence cellulaire. La re-expression de la télomérase, une enzyme qui aide à maintenir la longueur des télomères et à prévenir leur raccourcissement, est un événement fréquemment observé dans les cellules tumorales. Cette re-expression est probablement essentielle à la formation et à la croissance soutenue de la majorité des cancers.
Influence of multidrug efflux systems on methylene blue-mediated photodynamic inactivation of Candida albicans (2011)

The ABC pumps are directly implicated in MB efflux from the cell cytoplasm. Both the influx and efflux of MB may be regulated by MFS systems, and blocking this gate before incubation with MB can decrease the uptake and APDI effects. An ABC inhibitor could be usefully combined with MB APDI for treating C. albicans infections.
Subcortical (thalamic) automated seizure detection: A new option for contingent therapy delivery (2015)

The feasibility of automated detection of cortical-onset epileptic seizures from subcortical structures such as the thalamus was investigated via simultaneous recording of electroencephalography (EEG) and anterior and centromedian thalamic nuclei electrical signals (electrothalamography) in nine subjects with pharmacoresistant seizures admitted to an epilepsy monitoring unit after deep brain stimulating electrode implantation. Thalamic electrical signals were analyzed using a validated seizure detection algorithm, and times of seizure onset and termination were compared to those determined through visual analysis of video-EEG. Ictal activity was recorded from the scalp and thalamic nuclei in three subjects who had seizures during the 3-4-day recording period. In the majority of seizures, ictal activity in the thalamic nuclei preceded electrographic onset as determined from the EEG or clinical onset as determined from behavioral observations. Interictal epileptiform discharges were also recorded from the thalamus and in certain instances had no scalp representation. Subcortical/thalamic detection of cortical-onset seizures is feasible. This approach would enable contingent therapy delivery and may be particularly valuable for subjects with multiple or difficult-to-localize epileptogenic regions.
Kinetics of African swine fever virus infection in Ornithodoros erraticus ticks (2006)

The kinetics of African swine fever virus (ASFV) infection in Ornithodoros erraticus ticks were investigated in specimens collected in the field at different times following an outbreak of the disease in Portugal in 1999 and in ticks infected experimentally with a virus isolated from a tick collected during this outbreak. In ticks collected from the field, initial screening for ASFV was carried out by PCR, followed by attempts to isolate the virus in macrophage cultures. Considering total numbers of ticks tested independently of developmental stages, ASFV DNA was detected in 42.3, 26.4 and 22.4% of specimens collected at weeks 0, 32 and 63 following the outbreak, respectively. Although virus was not isolated from most of these ticks, the proportion of isolations from large nymphs and adults increased between weeks 0 and 32 from 2 to 9 % and from 5 to 11.5%, respectively. These results, together with the higher virus titres at week 32, suggest that virus replication occurred. In contrast, virus isolations from small nymphs decreased over this period, from 5 to 1.3%. At week 63, infection rates decreased for all stages. Experimental infections showed the occurrence of virus replication within 4 weeks post-feeding and maintenance of high titres in almost 100% of ticks until 20 weeks post-infection. At weeks 41 and 61, a drop in virus titres and infection rates was observed. Relevant to the understanding of African swine fever epidemiology, our results show that ASFV replicates and persists in O. erraticus, but a viral clearance occurs at later times in both natural and experimental infections.
Experimental Investigation of Sampling Phase Sensitivity in Baud-Rate Sampled Coherent Receiver for Nyquist Pulse-Shaped High-Order QAM Signals (2014)

We experimentally investigate the sampling phase dependence of baud-rate sampled and equalized coherent receiver for Nyquist Pulse-shaped high-order QAM signals on the modulation format and roll-off factors.
Time-Domain-Based Measurement Technique for Pressure Measurement in a Wearable Wireless Sensor Patch (2018)

Implementation of a Pressure Ulcer Prevention System would reduce health care costs by improving pressure ulcer prevention, enabling patient treatment, monitoring outside a hospital setting, and easing workload on caregivers. In order to achieve the above said goals, it is important to be able to measure local skin pressure accurately. Disadvantages of a voltage-based resistance measurement technique include the need for a steady reference voltage and accurate ADC, each of which introduces additional error and power dissipation. This paper presents a novel interfacing technique for resistive force sensors, allowing the determination of resistance using a time-based measurement approach.