gebhart/patrepeval huggingface dataset:
A Memory Hierarchical Layer Assigning and Prefetching Technique to Overcome the Memory Performance/Energy Bottleneck (2007)

The memory subsystem has always been a bottleneck in performance as well as significant power contributor in memory intensive applications. Many researchers have presented multi-layered memory hierarchies as a means to design energy and performance efficient systems. However, most of the previous work do not explore trade-offs systematically. We fill this gap by proposing a formalized technique that takes into consideration data reuse, limited lifetime of the arrays of an application and application specific prefetching opportunities, and performs a thorough trade-off exploration for different memory layer sizes. This technique has been implemented on a prototype tool, which was tested successfully using nine real-life applications of industrial relevance. Following this approach we have able to reduce execution time up to 60%, and energy consumption up to 70%.
A New Ar Desorption Peak in Thermal Desorption Spectroscopy Measurement of Sputtered HfO<sub>2</sub> Accompanied by its Structural Phase Transformation (2013)

2013 International Conference on Solid State Devices and Materials,A New Ar Desorption Peak in Thermal Desorption Spectroscopy Measurement of Sputtered HfO<sub>2</sub> Accompanied by its Structural Phase Transformation
Polarization absorption spectroscopy: Determination of the direction and degree of orientation of absorption transitions (1982)

In an ordered, directional medium, such as liquid crystals or biological membranes, it is often desirable to determine both the degree of ordering (i.e., order parameters) and the directions in space which most aptly characterize it. Here, a method is presented for determining these quantities relative to a laboratory frame. It consists in measuring changes in the light absorbed by a pleochroic dye dissolved in dilute quantity in a directionally ordered medium (e.g., nematic liquid crystal or lipid bilayer) as functions of polarization and angles of incidence. The results of testing this method on a model system of dilute mixtures of dyes in a room temperature nematic liquid crystal are presented. In principle, only six such measurements are necessary to make these determinations; however, some redundancy is desirable to obtain sufficiently accurate results. We show that an accuracy of 5% or better can be obtained from nine measurements. A detailed discussion of the errors that can be expected is given.
Desenvolvimento de fármacos para tratamento da COVID-19 (2020)

A Covid-19 e uma nova doenca, causada pelo SARS-CoV-2, pandemia ainda em curso, causando mais de 450 mil obitos apos 6 meses da descoberta do virus e nao ha medicamento eficaz ou vacina ate o momento. A emergencia mundial para busca de tratamento especifico contra a COVID-19, demandou o uso de estrategias para descoberta que fossem mais rapidas, incluindo o reposicionamento de farmacos.  Este trabalho visa descrever as estrategias no desenvolvimento de farmacos para o tratamento da COVID-19, abordando os alvos terapeuticos.
Physiologic data acquisition system and database for the study of disease dynamics in the intensive care unit* (2003)

We have successfully developed a real-time, continuous physiologic data acquisition system that can capture, store, and archive data from pediatric intensive care unit patients for subsequent time series analysis of dynamic changes in physiologic state. The physiologic signal database generated from this system is available for analysis of dynamic changes caused by critical illness and injury.
Statistical Learning of Neuronal Functional Connectivity (2016)

Identifying the network structure of a neuron ensemble beyond the standard measure of pairwise correlations is critical for understanding how information is transferred within such a neural population. However, the spike train data pose significant challenges to conventional statistical methods due to not only the complexity, massive size, and large scale, but also high dimensionality. In this article, we propose a novel “structural information enhanced” (SIE) regularization method for estimating the conditional intensities under the generalized linear model (GLM) framework to better capture the functional connectivity among neurons. We study the consistency of parameter estimation of the proposed method. A new “accelerated full gradient update” algorithm is developed to efficiently handle the complex penalty in the SIE-GLM for large sparse datasets applicable to spike train data. Simulation results indicate that our proposed method outperforms existing approaches. An application of the proposed method to a real spike train dataset, obtained from the prelimbic region of the prefrontal cortex of adult male rats when performing a T-maze based delayed-alternation task of working memory, provides some insight into the neuronal network in that region.
Synthesis of the Enantiomers of 6-Deoxy-myo-Inositol 1,3,4,5-Tetrakisphosphate, Structural Analogues ofmyo-Inositol 1,3,4,5-Tetrakisphosphate (2001)

In the paper by G. Horne and B. V. L. Potter published in Chem. Eur. J. 2001, 7, 80, there is a mistake in the drawing of some regiochemistry of the structural diagrams in Schemes 1–3. The correct structures are given below.
Effects of artificial turf on performance and ground contact kinetics during a sprint acceleration (2013)

Click to increase image sizeClick to decrease image size Notes * Statistically significantly different compared to Indoor Shoe on Lab Floor + Statistically significantly different compared to Indoor Shoe on Artificial Turf
An inverse finite element minimization‐based method for solution of multi‐dimensional phase‐change and material boundary shapes (1994)

Abstract An inverse finite element method for solution of unknown multidimensional phase‐change and material boundary shapes is presented. The method is based on minimization and requires boundary shape parametrization. The unknown boundary parameters are determined by minimizing the error between a limited number of known (e.g. measured) temperatures and the temperatures associated with the iteratively altered boundary. The algorithm presented is based on the multidimensional downhill simplex minimization method. The inverse method is illustrated and verified using a model of the plasma arc welding process. In particular, it is shown that the technique is capable of accurately determining a specified weld pool capillary interface shape using a limited number of simulated thermocouple measurements. The code's ability to determine the interface shape is investigated under various interface‐thermocouple separations, using varying numbers of simulated thermocouples.
Development of MEMS Hot-Film Sensors for Use in the Integrated Wing Project (2008)

As part of a large UK project called “Integrated Wing, Flight Physics, Technology Validation Programme”, BAE Systems have been further developing their hot-film sensors constructed using silicon manufacturing techniques with the ultimate aim of making them capable of being certified for flight. Primarily, this has involved looking at aspects of the sensor design, such as the robustness of the sensors to impacts and their resistance to environmental degradation. Tests done to date have shown that provided the sensors have a thin protective coating of a few microns thickness and are not installed close to the leading-edge of a wing they should be capable of being certified for flight.
TX-RX isolation method based on polarization diversity, spatial diversity and TX beamforming (2016)

In this paper, the feasibility of an antenna isolation technique based on null-steer beamforming, polarization diversity and spatial diversity is investigated. The proposed system consists of six patch antennas which are fed by a feeding network to obtain a null-steer beamformer. To achieve spatial diversity, antenna elements are located on two layers, facing in a different direction. Moreover, the antenna elements in two layers use different polarization. The measured results of the antenna system present a high TX-RX isolation in the order of 70 dB which shows the feasibility of such a system for Full-duplex transmission.
Predicting tumor fat invasion in clinical T1 tumors (2015)

De, Sumit; Handorf, Elizabeth PhD; Uzzo, Robert G. MD, FACS; Chen, David Y. MD, FACS; Viterbo, Rosalia MD, FACS; Greenberg, Richard E. MD, FACS; Haseebuddin, Mohammed MD; Waingankar, Nikhil MD; Smaldone, Marc C. MD, MSHP; Kutikov, Alexander MD, FACS Author Information
3D Printing of Biocompatible Supramolecular Polymers and their Composites (2016)

A series of polymers capable of self-assembling into infinite networks via supramolecular interactions have been designed, synthesized, and characterized for use in 3D printing applications. The biocompatible polymers and their composites with silica nanoparticles were successfully utilized to deposit both simple cubic structures, as well as a more complex twisted pyramidal feature. The polymers were found to be not toxic to a chondrogenic cell line, according to ISO 10993-5 and 10993-12 standard tests and the cells attached to the supramolecular polymers as demonstrated by confocal microscopy. Silica nanoparticles were then dispersed within the polymer matrix, yielding a composite material which was optimized for inkjet printing. The hybrid material showed promise in preliminary tests to facilitate the 3D deposition of a more complex structure.
In vivo persistence and protective efficacy of the Bacille Calmette Guérin vaccine overexpressing the HspX latency antigen (2010)

New strategies to control infection with Mycobacterium tuberculosis, the causative agent of tuberculosis, are urgently required, particularly in areas where acquired immunodeficiencies are prevalent. In this report we have determined if modification of the current tuberculosis vaccine, Mycobacterium bovis BCG, to constitutively express the mycobacterial HspX latency antigen altered its protective effect against challenge with virulent M. tuberculosis. Overexpression of M. tuberculosis HspX in BCG caused reduced growth in aerated cultures compared to control BCG, but growth under limited oxygen availability was not markedly altered. Upon infection of mice, BCG:HspX displayed tissue-specific attenuation compared to control BCG, with reduced growth within the lung and liver but not the spleen. Both BCG:HspX and control BCG protected mice against aerosol M. tuberculosis challenge to a similar extent, however, immunodeficient mice infected with BCG:HspX survived significantly longer than mice infected with the control BCG strain. Therefore, altering the in vivo persistence of BCG by overexpression of HspX may be one important step towards developing a new tuberculosis vaccine with an improved safety profile and suitable protective efficacy against M. tuberculosis infection.
Uremia and Hypoxia Independently Induce Eryptosis and Erythrocyte Redox Imbalance (2019)

In summary, our results indicate that the concurrent presence of hypoxia and uremia augments RBC death and may therefore, contribute to the genesis of anemia in CKD.
Realstruktur von Einkristallen und die Intensitäten von Braggreflexen (1993)

Single-crystal diffractometry can be used to characterize the defect structure of single-crystals up to the level of point defects. This paper deals with the information content of integrated Bragg intensities of weak as well as of fundamental reflections. Experimental possibilities of conventional X-rays and synchrotron radiation are compared. The integrated Bragg intensity is an objective in materials science for the development of highefficiency monochromators. The importance of berylliumbased materials for new synchrotron and neutron monochromators is discussed and first results are presented
Small Unit Operations (1998)

Abstract : DARPA requested a JASON summer study on Small Unit Operations, with the emphasis to be on the SUO vision of total situational awareness for small ground units, remote commanders and remote weapons systems. The study focused on new technologies and concepts which might lead to a dramatic improvement in battlefield situational awareness.
Effects of subthalamic deep brain stimulation on striatal metabolic connectivity in a rat hemiparkinsonian model (2019)

Deep brain stimulation (DBS) in the subthalamic nucleus (STN) has been successfully used for the treatment of advanced Parkinson's disease, although the underlying mechanisms are complex and not well understood. There are conflicting results about the effects of STN-DBS on neuronal activity of the striatum, and its impact on functional striatal connectivity is entirely unknown. We therefore investigated how STN-DBS changes cerebral metabolic activity in general and striatal connectivity in particular. We used ipsilesional STN stimulation in a hemiparkinsonian rat model in combination with [<sup>18</sup>F]FDOPA-PET, [<sup>18</sup>F]FDG-PET and metabolic connectivity analysis. STN-DBS reversed ipsilesional hypometabolism and contralesional hypermetabolism in hemiparkinsonian rats by increasing metabolic activity in the ipsilesional ventrolateral striatum and by decreasing it in the contralesional hippocampus and brainstem. Other STN-DBS effects were subject to the magnitude of dopaminergic lesion severity measured with [<sup>18</sup>F]FDOPA-PET, e.g. activation of the infralimbic cortex was negatively correlated to lesion severity. Connectivity analysis revealed that, in healthy control animals, left and right striatum formed a bilateral functional unit connected by shared cortical afferents, which was less pronounced in hemiparkinsonian rats. The healthy striatum was metabolically connected to the ipsilesional substantia nigra in hemiparkinsonian rats only (OFF condition). STN-DBS (ON condition) established a new functional striatal network, in which interhemispheric striatal connectivity was strengthened, and both the dopamine-depleted and the healthy striatum were functionally connected to the healthy substantia nigra. We conclude that both unilateral dopamine depletion and STN-DBS affect the whole brain and alter complex interhemispheric networks.
Modeling Microfabricated Multipoint Fuze Initiators Part 1: Pre-Melting Behavior (2008)

Abstract : Future combat systems require warheads with multi-point initiators to produce precise simultaneous detonations. Semiconductor fabrication methods, combined with MEMS-enabling process technologies at ARL, enable geometrically accurate conductors bridge wire for such multipoint initiators. To understand how our device design, material deposition, and post processing influence bridge wire performance and ultimately simultaneity, we have simulated the behavior of an exploding metal bridge. In this report we present results focusing on the thermalelectric problem of heating up to the bridge wire melting point. The results in terms of time for the center of the exploding foil to reach the material melting temperature was within 2% of a similar, published modeling study, and approximately within 20% of the experimentally observed time-to-burst for specific geometries fabricated at ARL. We also performed a sensitivity study and found the melting time to be most sensitive to bridge wire thickness, and all material properties except thermal conductivity. Simple, analytical arguments explain these results. Finally, we detail a path forward to eventually result in a predictive model allowing direct comparison between model outputs and experimental data. Such a model will greatly enhance our ability to design better bridge wire devices.
Camera-based measurement of respiratory rates is reliable (2017)

In our pilot study, we found that camera-based measurements delivered accurate and reliable results. Future studies need to show that camera-based measurements are a secure alternative for measuring RRs in clinical settings as well.
Incremental Cluster Validity Indices for Hard Partitions: Extensions and Comparative Study (2019)

Validation is one of the most important aspects of clustering, but most approaches have been batch methods. Recently, interest has grown in providing incremental alternatives. This paper extends the incremental cluster validity index (iCVI) family to include incremental versions of Calinski-Harabasz (iCH), I index and Pakhira-Bandyopadhyay-Maulik (iI and iPBM), Silhouette (iSIL), Negentropy Increment (iNI), Representative Cross Information Potential (irCIP) and Representative Cross Entropy (irH), and Conn_Index (iConn_Index). Additionally, the effect of under- and over-partitioning on the behavior of these six iCVIs, the Partition Separation (PS) index, as well as two other recently developed iCVIs (incremental Xie-Beni (iXB) and incremental Davies-Bouldin (iDB)) was examined through a comparative study. Experimental results using fuzzy adaptive resonance theory (ART)-based clustering methods showed that while evidence of most under-partitioning cases could be inferred from the behaviors of all these iCVIs, over-partitioning was found to be a more challenging scenario indicated only by the iConn_Index. The expansion of incremental validity indices provides significant novel opportunities for assessing and interpreting the results of unsupervised learning.
Psychosomatics and dentistry (1964)

The psychosomatic concept in dentistry has been approached two-fold manner: a) the interrelationship of psychological factors and dental problems as reflected in the literature has been discussed, confirming the hypothesis that psychosomatic dentistry should be acknowledged by the dental profession as integral part of the dental school curriculum; b) a second hypothesis, namely a possible correlation between dental decay and psychopathology has been tested as follows: 70 institutionalized mentally ill patients, 25 males and 45 females, were administered the MMPI (Minnesota Multiphasic Personality Inventory), ICL (Interpersonal Check List), and the following indices were determined: Russell's periodontal classification, the DMFT (Decayed, Missing and Filled Teeth) and the DMFS (Decayed, Missing and Filled Surfaces). Findings show the average number of teeth and tooth surfaces affected, using the DMFT and DMFS were found to be more for the institutionalized mentally ill than for the average non-institutionalized person. Findings also show that while the ICL did not correlate with the dental scores, some of the MMPI scores did. The MMPI, considered by psychologists a much more subtle instrument than the Interpersonal Check List, did yield some positive results in this study, thus supporting to some degree the hypothesis that there is a relationship between dental decay and psychopathology.
Structuring Time Domain Blind Source Separation Algorithms for CASA Integration (2006)

Most algorithms based on Computational Auditory Scene Analysis (CASA) for binaural speech separation do not have the ability to inhibit already localized and for a long time present sources in the auditory scene. This has the major drawback that the auditory cues of weaker and new sources are subject to interference from already localized and perceived signals and the separation performance is worse if the signals overlap in their processing domain. In this paper we outline how one can build intuitively a separation system that has this inhibition feature. The main block and starting point of our derivation is a simple cross correlation based localization system with two microphones. The inhibition is achieved by feeding back localization results to a filter and sum structure that cancels localized sounds. Interestingly, our intuitive approach leads to a special case of a well known time domain blind source separation algorithm which was derived from a statistical signal processing viewpoint and exhibits good convergence even in reverberant environments. Finally, we discuss how the insights gained from building a blind source separation this way can be used to integrate CASA techniques. 1.
A Case of Gynecomastia Induced by Use of Doxazosin (2016)

Doxazosin is an adrenergic alpha-1 receptor antagonist used to treat lower urinary tract symptoms that are common in prostatic hyperplasia. To our knowledge, few cases of gynecomastia and mastodynia, as a complication of adrenergic alpha-1 receptor antagonist, have been reported to date; no cases have been reported in Korea. We describe a case involving a 78-year-old man treated for prostatic hyperplasia with 13 months of doxazosin. He complained about unilateral gynecomstia and mastodynia. Five months after the discontinuation of doxazosin, the gynecomastia was significantly improved. This is the first reported case of gynecomastia and mastodynia associated with doxazosin use in Korea. (
Editorial: Bypassing the Biological Barriers by Means of Biocompatible Drug Delivery Systems (2021)

Passage of a drug across a biomembrane, such as the cell bilayer, a blood vessel and the 11 bowel endothelia, the skin, the blood brain barrier, is influenced by its physicochemical properties as 12 well as the characteristics of the biomembrane (Shinoda. 2016;Di Meo et al., 2016). Biomembranes 13 contain cellular material in a closed space and and provide a dynamic interface for interaction with 14 extracellular milieu. However, from pharmaceutical perspective, biomembranes can also act as a 15 barrier to drug delivery. Knowledge of these influences can provide us with a capability to localize 16 drug in specific body compartments by modifying the delivery systems, altering the route of 17 administration, incorporating the compartment-specific targeting moieties, etc. With a goal of 18 promoting drug permeation across a biomembrane, these techniques and approaches essentially hinge 19 on modulation of the interaction between the drug and the bilayer.
Chemically-inactive interfaces in thin film Ag/AgI systems for resistive switching memories (2013)

AgI nanoionics-based resistive switching memories were studied in respect to chemical stability of the Ag/AgI interface using x-ray absorption spectroscopy. The apparent dissolution of Ag films of thickness below some tens of nanometers and the loss of electrode/electrolyte contact was critically addressed. The results evidently show that there are no chemical interactions at the interface despite the high ionic mobility of Ag ions. Simulation results further show that Ag metal clusters can form in the AgI layer with intermediate-range order at least up to next-next nearest neighbors, suggesting that Ag can permeate into the AgI only in an aggregated form of metal crystallite.
The extremal properties of spatial stiffness matrices (2003)

In this paper, the structure and extremal properties of spatial stiffness matrices are investigated. From this work a better understanding of the spatial compliant behavior important in robot interaction tasks is attained. We develop a rank-1 decomposition of a spatial stiffness matrix which is independent of the coordinate frame used to describe the elastic behavior. We also identify the extremal properties associated with this decomposition. To attain better physical insight, analogies are drawn between this unique spatial stiffness matrix decomposition and the conventional eigenvalues decomposition of a translational stiffness matrix.