gebhart/patrepeval huggingface dataset:
Observations of G29 - 38 at 10 microns (1990)

The white dwarf G29 - 38 was shown by Zuckerman and Becklin (1987) to have an IR excess at 1-5 microns, possibly due to a spatially unresolved brown dwarf companion. Using the NASA-MSFC 20-pixel bolometer array at the IRTF, a 10.8-micron flux density of 9.5 + or - 3.1 mJy is detected from G29 - 38. This value, combined with more recent 10-micron data obtained by others, implies that 10-micron emission from G29 - 38 is at least twice that expected from a brown dwarf having an effective temperature in the range 1100-1500 K, as previously estimated. The possibility that the IR excess is emitted by dust rather than a brown dwarf is therefore strengthened.
Compte-rendu de la matinée consacrée à l’immunologie cellulaire (2010)

La découverte du système HLA – et de son homologue H-2 chez la souris – a eu d’immenses répercussions en immunologie. Plusieurs ont été évoquées lors d’une première séance sur l’immunologie cellulaire, présidée par M. Sasportes (Paris). Les gènes codant pour les antigènes majeurs d’histocompatibilité sont très polymorphes. On connaît aujourd’hui plusieurs milliers d’allèles de gènes codant pour les antigènes « classiques » de classe I et II. Comme chaque être humain possède trois gènes de cha...
Next Generation Intel¯ Core™ Micro-Architecture (Nehalem) Clocking (2009)

This paper describes the core and I/O clocking architecture of the next generation Intel <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">reg</sup> Coretrade micro-architecture processor (Nehalem), designed on a 45 nm process technology. Local PLL placement provides modularity and power-efficient scalability by allowing independent frequency and voltage domains. Fast-locking, low-skew PLLs are used to achieve 56% lock time reduction and 30% long-tem jitter improvement. Adaptive frequency, supply, and duty cycle mechanisms combine for up to 5% core frequency gain at iso-voltage. Jitter attenuating DLLs with enhanced linearity and plusmn15% duty cycle correction drive a differential, low-swing I/O receiver clock distribution, reducing jitter by 25% and enabling 25.6 GB/s Intel <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">reg</sup> QuickPath Interconnect bandwidth and three-channel DDR3 traffic up to 32 GB/s.
Hall conductivity dominated by fluctuations near the superconducting transition in disordered thin films (2012)

We have studied the Hall effect in superconducting tantalum nitride films. We find a large contribution to the Hall conductivity near the superconducting transition, which we can track to temperatures well above ${T}_{c}$ and magnetic fields well above the upper critical field ${\text{H}}_{c2}(0)$. This contribution arises from Aslamazov-Larkin superconducting fluctuations, and we find quantitative agreement between our data and recent theoretical analysis based on time-dependent Ginzburg-Landau theory.
Perforin, a pore-forming protein detectable by monoclonal antibodies, is a functional marker for killer cells (1990)

Perforin is one of the important cytolytic factors in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. In this paper, we report rat mAbs against mouse perforin established by immunization with a recombinant mouse perforin fragment. These mAbs reacted with purified mouse perforin prepared from cytoplasmic granules of an NK-like cell line in ELISA and Western blot analysis. However, none of these mAbs blocked the hemolytic activity of mouse perforin or absorbed it when fixed in the solid phase. These results indicate that all of these mAbs react with denatured but not with native mouse perforin. By using a combination of the mAbs, we established a sandwich ELISA, for quantitating the cellular contents of perforin. These mAbs were also useful for immunohistochemical staining analysis, and perforin was detected in the cytoplasmic granules of CTL and NK cell lines. Perforin was also detected in a minor population of lymphocytes of the spleen, liver, and lymph node. In normal spleen cells of 5- to 8-week-old mice, 12-15% of asialo GM1+ cells and 7-21% of CD8+ T cells were perforin-positive, but CD4+ T cells, B cells, and macrophages were totally negative. These data clearly show that perforin is expressed in cells of a cytotoxic character in normal mice, in the same way as in primed mice.
Evidence of the Anomalous Charge StateFe4+57in the Nuclear Decay ofCo3+57 (1986)

The first observation of the elusive ${\mathrm{Fe}}^{4+}$ charge state coming from the nuclear decay of $^{57}\mathrm{Co}^{3+}$ has been found in the M\"ossbauer emission spectra of $^{57}\mathrm{Co}$:${\mathrm{La}}_{2}$${\mathrm{Li}}_{0.5}$${\mathrm{Co}}_{0.5}$${\mathrm{O}}_{4}$. A Ti-doped sample was prepared in order to show that the ${\mathrm{Fe}}^{4+}$ fraction can be conveniently monitored. Both results were predicted on the basis of the electronic energy-band scheme of these oxides.
Spectral Narrowing and Stabilization of 10-W Broad-Area Laser With Fiber Pump Delivery System (2018)

The emission spectrum of a 10-W commercial broad-area laser operated at full power was narrowed and stabilized by coupling an off-axis portion of its far-field emission to a single-mode fiber Bragg grating. The feedback produced in this partial compound cavity configuration narrowed the FWHM linewidth of the laser by 7× compared with the free-running case and stabilized its peak wavelength over a 7° temperature range. Furthermore, the feedback improved the spectral density of the emission by 2× over a 1.5° temperature range and over most of the far-field emission angles, indicating a robust concept suitable for manufacturing. This proof-of-concept experiment can be translated into a fiber pump delivery system that can capture all the broad-area laser (BAL) output while providing feedback to improve the spectral and potentially spatial properties of BAL emission.
Preliminary thoughts on problem-oriented shared memory (1985)

Much of the work to date on distributed systems has focused on the correct choice of communication paradigm , stressing (for example) message primitives, remote procedure call, problem- oriented protocols and so on. A distributed system service is then implemented as a module executing on particular server machine that is accessed using these communication facilities. In contrast, the shared memory paradigm has been used on multiprocessor and uniprocessor systems. In the shared memory paradigm, the state of a service is stored in shared memory and implemented in a decentralization fashion across multiple processors using this shared memory.This paper describes some preliminary thoughts on applying the shared memory paradigm to distributed systems. For efficiency reasons, shared memory is not provided in its full generality, but only with the semantics required for the applications of interest. This type of application-specific memory is called a problem-oriented shared memory . The use of problem- oriented shared memory is illustrated by describing several applications we are exploring in the V distributed system. We also discuss basic requirements on a communication system to support this approach.
Functionalised zinc oxide nanotube arrays as electrochemical sensors for the selective determination of glucose (2011)

In the present study, highly oriented single-crystal zinc oxide nanotube (ZnO-NT) arrays were prepared by a trimming of ZnO nanorods along the c-axis on the gold-coated glass substrate having a diameter of 100–200 nm and a length of ∼1 µm using a low-temperature aqueous chemical growth process. The prepared (ZnO-NT) arrays were further used as electrochemical enzyme-based glucose sensors through immobilisation of glucose oxidase by the physical adsorption method in conjunction with a Nafion coating. The electrochemical response of the sensor was found to be linear over a relatively wide logarithmic concentration range from 0.5×10−6 to 12×10−3 M. The proposed sensor showed a high sensitivity of 69.12 mV/decade with R=0.9934 for sensing of glucose. A fast-response time less than 4 s with good selectivity, reproducibility and negligible response to common interferents such as ascorbic acid and uric acid prevailed.
High-sensitive troponin T in chronic heart failure correlates with severity of symptoms, left ventricular dysfunction and prognosis independently from N-terminal pro-b-type natriuretic peptide (2011)

Hs-cTnT increases stepwise with the severity of symptoms and LV dysfunction and offers important prognostic information in chronic heart failure, independently from and additive to NT-proBNP. The utility of hs-cTnT expands beyond acute myocardial ischemia and towards chronic heart failure.
4Pi-SHG imaging of mammalian myofibrillar structures (2006)

Intrinsic Second Harmonic Generation (SHG) signals obtained from the motor protein myosin are of particular interest for 3D-imaging of living muscle cells. In addition, the new and powerful tool of 4Pi microscopy allows to markedly enhance the optical resolution of microscopy as well as the sensitivity for small objects because of the high peak intensities due to the interference pattern created in the focus. In the present study, we report, to our knowledge for the first time, measurements of intrinsic SHG signals under 4Pi conditions of type A. These measurements on mammalian myofibrilar structures are combined with very high resolution 4Pi fluorescence data obtained from the same preparations. We have chosen myofibrillar preparations of isolated mammalian muscle fibers as they (i) possess a regular repetitive pattern of actin and myosin filaments within sarcomers 2 to 3 &#956;m in length, (ii) consist of single myofibrils of small total diameter of approximately 1 &#956;m and (iii) are ideally suited to study the biomedically important process of force generation via calcium regulated motor protein interactions. Myofibrillar preparations were obtained from murine skeletal and heart muscle by using a combined chemical and mechanical fractionation<sup>1</sup> (Both et al. 2004, JBO 9(5):882-892). BODIPY FL phallacidin has been used to fluorescently label the actin filaments. The experiments were carried out with a Leica SP2 multi photon microscope modified for 4Pi measurements using a Ti:Sa laser tuned to 850-900 nm. SHG as well as fluorescence photons were detected confocally by a counting APD detector. The approach taken our study provides new 3D-data for the analysis and simulation of the important process of excitation-contraction coupling under normal physiological as well as under pathophysiological conditions.
Alkene Based Monolayer Films as Anti-Stiction Coatings for Polysilicon MEMS (2000)

This paper describes a new class of anti-stiction coatings for silicon MEMS that is based on the free radical reaction of a primary alkene (e.g., I-octadecene, Ct6H&H=CH2) with hydrogen terminated silicon The new monolayer coating has several key advantages over the previously reported octadecyltrichlorosilane W-S) and lH, 1 H,2H,2Hperfluorodecyltrichlorosilane (FDTS) based self-assembled monolayers (SAMs) 2) The coating does not require the formation of an intervening oxide layer. 3) The film formation procedure for alkene-based monolayers is simpler than for chlorosilane-based SAMs for two main reasons. First, the surface oxidation step is eliminated.
Genomic analysis and 3-y efficacy and safety update of COMBI-d: A phase 3 study of dabrafenib (D) + trametinib (T) vs D monotherapy in patients (pts) with unresectable or metastatic BRAF V600E/K-mutant cutaneous melanoma. (2016)

9502 Background: Previous analysis of COMBI-d (NCT01584648) showed that D+T compared with D monotherapy improved ORR (69% [95% CI, 62%-75%] vs 53% [95% CI, 46%-60%]; P = 0.0014), reduced risk of progression (HR, 0.67 [95% CI, 0.53-0.84]; P = 0.0004) and death (HR, 0.71 [95% CI, 0.55-0.92]; P = 0.0107), and increased 2-y OS rate (51% vs 42%) in BRAFV600–mutant melanoma. Methods: In this phase 3, randomized, double-blind study, pts with histologically confirmed unresectable stage IIIC or IV, BRAF V600E/K–mutant melanoma were randomized 1:1 to receive frontline D 150 mg twice daily (BID) + T 2 mg once daily or D 150 mg BID only. The primary endpoint was PFS; secondary endpoints were OS, ORR, duration of response, and safety. Whole-exome sequencing was used to assess somatic mutations and copy number changes in pretreatment tumor (mean target coverage [MTC], 170×) and matched normal blood samples (MTC, 100×) collected from > 140 pts to further characterize BRAF V600–mutant melanoma and explore whether individual gene changes or genetic profiles were associated with treatment benefit. Results: A total of 423 pts were randomized to D+T (n = 211) or D (n = 212). As expected, initial genetic analysis of 130 pts showed that BRAF was the most frequently mutated gene (V600E, 83%; V600K, 15%). Additional mutations were observed in genes related to tumor suppression (TP53, PTEN, CDKND2A) and resistance to MAPK pathway inhibition (MEK1, MEK2, NRAS, NF1, RAC1), and amplifications were observed in BRAF and MITF. Overall mutation rate was higher in V600K vs V600E pts (median mutations per sample, 1701 vs 419; P< 0.0001). Updated genomic analysis, including OS and mutation rate association, and efficacy and safety results, including 3-y OS, will be presented. Conclusions: Preliminary genetic analyses showed additional mutations related to tumor suppression and MAPK inhibitor resistance were present in pts with BRAF-mutant melanoma, with a higher overall mutation rate in V600K-mutant tumors. Updated genetic analysis and 3-y efficacy and safety analysis will be presented. Clinical trial information: NCT01584648.
Compounds Isolated from Tannacetum polycephalum (2008)

Several known secondary metabolites, namely lupeol (1), b-sitosterol (2), stigmasterol (3), and 2,6-dimethoxy-4-hydroxy acetophenone (4) were isolated from a folkloric medicinal plant, Tannacetum polycephalum. The structures of these compounds were elucidated on the basis of various spectroscopic methods.
ChemInform Abstract: Regioselective Proton Abstraction and 1,3‐Migration of a Phosphorus Group in 1,3‐Dienes by Iron Coordination: A New Method for the Synthesis of α‐Phosphono‐α,β‐unsaturated Ketones. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Towards a resource management and service deployment framework (2007)

Abstract Owing to the increase in both heterogeneity and complexity in today's networking systems, the need arises for new network‐based services architectures. They must provide flexibility and efficiency in the definition, deployment and execution of the services and, at the same time, handle the adaptability and evolution of such services. In this paper we present an approach that applies a Web‐service‐based resource management framework. It enables the provision of parallel applications as QoS‐aware applications, whose performance characteristics may be dynamically negotiated between a client application and service providers. Our component model allows context dependencies to be explicitly expressed and dynamically managed with respect to the hosting environment, computational resources and dependencies on other components. In such a model the resource management, in terms of representation, allocation and management of the resources, plays a vital role regarding the efficiency of the entire dynamic service deployment architecture. Copyright © 2007 John Wiley &amp; Sons, Ltd.
Design and Rationale of the Global Phase 3 NEURO-TTRansform Study of Antisense Oligonucleotide AKCEA-TTR-LRx (ION-682884-CS3) in Hereditary Transthyretin-Mediated Amyloid Polyneuropathy (2021)

The study is registered at ClinicalTrials.gov (NCT04136184) and EudraCT (2019-001698-10).
Resistance of Enlist™(AAD-12) Cotton to Glufosinate (2017)

Enlist™ cotton contains the aad-12 and pat genes that confer resistance to 2,4-D and glufosinate, respectively. Thirty-three field trials were conducted focused on Enlist cotton injury from glufosinate as affected by cotton growth stage, application rate, and single or sequential applications. Maximum injury from a single application of typical 1X (542 g ae ha -1 ) and 2X use rates was 3 and 13%, respectively, regardless of growth stage. Injury from sequential applications of 1X or 2X rates was equivalent to single applications. Similar injury was observed with four commercial formulations of glufosinate. Cotton yield was never affected by glufosinate. This research demonstrates Enlist™ cotton has robust resistance to glufosinate at rates at least twice the typical use rate when applied once or twice at growth stages ranging from 2 to 12 leaves.
The role of dilation and confining stresses in shear thickening of dense suspensions (2010)

Many densely packed suspensions and colloids exhibit a behavior known as Discontinuous Shear Thickening in which the shear stress jumps dramatically and reversibly as the shear rate is increased. We performed rheometry and video microscopy measurements on a variety of suspensions to determine the mechanism for this behavior. Shear profiles and normal stress measurements indicate that, in the shear thickening regime, stresses are transmitted through frictional rather than viscous interactions, and come to the surprising conclusion that the local constitutive relation between stress and shear rate is not necessarily shear thickening. If the suspended particles are heavy enough to settle we find the onset stress of shear thickening tau_min corresponds to a hydrostatic pressure from the weight of the particle packing where neighboring particles begin to shear relative to each other. Above tau_min, dilation is seen to cause particles to penetrate the liquid-air interface of the sheared sample. The upper stress boundary tau_max of the shear thickening regime is shown to roughly match the ratio of surface tension divided by a radius of curvature on the order of the particle size. These results suggest a new model in which the increased dissipation in the shear thickening regime comes from frictional stresses that emerge as dilation is frustrated by a confining stress from surface tension at the liquid-air interface. When instead the suspensions are confined by solid walls and have no liquid-air interface, we find tau_max is set by the stiffness of the most compliant boundary which frustrates dilation. This rheology can be described by a non-local constitutive relation in which the local relation between stress and shear rate is shear thinning, but where the stress increase comes from a normal stress term which depends on the global dilation.
2-D Self-Injection-Locked Doppler Radar for Locating Multiple People and Monitoring Their Vital Signs (2020)

This article presents the combination of a self-injection-locked (SIL) radar with frequency-modulated continuous-wave (FMCW) and switched phased-array (SPA) techniques to locate multiple people and detect their vital signs with high resolution and high sensitivity. The proposed system utilizes a subharmonic upconverter/downconverter with a 1.675-2.175-GHz chirp local oscillator (LO) signal to convert between a 2.45-GHz SIL IF signal and a 5.8-6.8-GHz FMCW RF signal. It transmits the FMCW RF signal and receives the echo signal using a transmit (Tx) antenna and a switched receive (Rx) antenna array, respectively, and processes the SIL IF signal to produce a range-azimuth map (RAM) that displays the positions of all people, their respiration rates (RRs), and their heart rates (HRs) in the monitoring region. The key advantage of combining the FMCW and SPA techniques is the provision of higher spatial resolution than obtained using each technique alone. This article also proposes a Doppler-weighted RAM to improve the identifiability of the images that are generated by two persons close to each other. Finally, the presented system was experimentally validated by measuring the locations and vital signs of up to five seated persons at a range of more than 1.5 m, of which two persons were seated almost shoulder by shoulder.
Fixturering av pinnstång och kurvgejd till stigortshiss (2003)

Validerat; 20101217 (root)
Cooper-Pair Box as a Variable Capacitor (2005)

We calculate the effective capacitance of a Cooper-pair box and demonstrate that the Cooper-pair box can be used as a variable capacitor. The gate voltage modulates the charge transfer through the small junction in the Cooper-pair box, leading to a gate-dependent capacitance. We describe ongoing experiments to use an Al/AlO/sub x//Al Cooper-pair box as a tunable circuit element at milli-Kelvin temperatures and discuss possible applications to quantum computing as a variable coupling element between two Josephson junction qubits.
Abstract 2025: Prevention of mammary tumor progression via intraductal injection of nanoparticle-formulated siRNA. (2013)

Abstract The contribution of specific genes to the development and progression of mammary tumors has been hampered by the inability to silence these genes locally in the mammary gland. Localized intraductal chemotherapy treatments have been explored and offer significant advantages in terms of reduced toxicity and side effects. Therefore, we wanted to explore the possibility of gene knockdown using siRNA delivery via intraductal injection. FVB C3(1)-SV40Tag transgenic female mice spontaneously develop hyperplastic mammary lesions that progress to invasive mammary tumors. Hyperplastic ducts form as early as 12 weeks of age and progress into DCIS-resembling tumors by 16 weeks of age. These further develop into invasive tumors that invade locally into adipose tissue and muscle and occasionally form metastases to lung by 18 to 20 weeks of age. We intraductally injected nanoparticle-formulated siRNA targeted to the SV40 T-antigen transgene beginning at 8 weeks of age through 23 weeks of age into the mammary gland twice a month. As controls, transgenic females were either left untreated or intraductally injected with a non-targeting siRNA. Tumor formation was monitored using ultrasound technology that allows for tumor detection as early as 0.4mm in diameter. At 23 weeks of age, when 100% of the control mice developed tumors, only 1 of 8 mice that received siRNA to the transgene had developed a small tumor. Histological analysis of the mammary glands confirmed development of early lesions but tumor progression was successfully prevented. Mammary lesions were analyzed for proliferation, apoptosis and expression of various markers of differentiation, including hormone receptor status. We showed that siRNA was not detectable in any other organs of the mouse, including the liver. Furthermore, we confirmed that frequent intraductal siRNA injection did not interfere with subsequent pregnancy or lactation, a period in which the mammary gland undergoes extensive remodeling to allow for milk production. Our long-term goal is to leverage the information we uncovered through this effort to target key genes we identified through gene network analysis aiming to prevent the progression of DCIS to invasive tumors. Moreover, this new technology can be utilized to explore the role of genes during specific times during development and tumor formation. Citation Format: Silva Krause, Amy Brock, Michael Goldberg, Donald E. Ingber. Prevention of mammary tumor progression via intraductal injection of nanoparticle-formulated siRNA. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2025. doi:10.1158/1538-7445.AM2013-2025