gebhart/patrepeval huggingface dataset:
A Switchable Inductively Coupled Connector for IPT Roadway Applications (2020)

A dynamic inductive power transfer (IPT) system is a safe and convenient solution to address the issues related to the limited battery capacity and travel distance of electric vehicles (EVs). In recent years, practical aspects of dynamic IPT systems have been investigated to advance various IPT technologies from laboratories to roadways. This paper suggests a configuration to mitigate some of the installation and maintenance concerns of IPT roadways by proposing a switchable inductively coupled connector. Besides providing galvanic isolation, the inductively coupled connector helps maintain a constant and load-independent current in the primary coupler. Moreover, each primary coupler is connected to a common H-bridge through a single DC switch minimizing the number of components required to energize each coupler independently. A mathematical analysis and simulation results have been provided to validate a scaled 3.3kW prototype IPT system employing the proposed configuration.
Controlled Gene Delivery Systems: Nanomaterials and Chemical Approaches (2020)

Successful gene therapy depends on the design of effective gene delivery systems. A gene delivery system is considered a powerful tool for the release of genetic material within cells resulting in a change in cell functions and protein production. The release of genes in a controlled manner by using appropriate carriers facilitates their release without side effects and increases the expression of genes at the released site. It is expected that significant changes in the combination of several genes and drugs can be provided by developing treatment systems sensitive to different stimuli such as redox potential, pH variations, temperature gradients, light irradiation, and enzyme activity. The most important advantages for the release of genes and stimuli-responsive therapeutics include delivering vectors locally, reducing side effects and causing no toxicity to distant tissues while at the same time reducing the immune response to the vectors. In this review, we aim to discuss different types of gene carriers involved in the controlled transfer of nucleic acids (non-viral inorganic and organic nanoparticles (NPs) and virus-like particles (VLPs)) as well as the simultaneous transfer of several genes and/or drugs into cells or different tissues, providing for an efficient and safe treatment of numerous diseases.
Sense and avoid radar using Data Fusion with other sensors (2011)

UAV (Unmanned Aerial Vehicle) are employed in crisis or war times. For training purposes, they must be flown in special areas called “segregated areas”. In the future, both for emerging civilian applications and for training purposes, UAV will have to be inserted into the general Air traffic. So, UAV will have to be equipped with “Sense and Avoid” systems. An interesting solution is to merge a co-operative sensor like ADS-B and a non-cooperative “all weather” one, namely Radar. In favorable cases, the Radar measurements can be improved by using additional Electro-Optical sensors, for instance video sensors.
A STREAMLINED ANAESTHETIC SYSTEM (1973)

A streamlined modification of the combined Mapleson D & E systems has been described. The main advantages of this circuit are that it is light in weight, adaptable to both adult and paediatric anaesthesia, allows complete airway control at all times, and permits the institution of positive pressure ventilation, The circuit is easily adaptable for pollution control.
Glycoprotein Erns of pestiviruses induces apoptosis in lymphocytes of several species (1997)

Classical swine fever virus and bovine virus diarrhea virus are members of the genus pestivirus, which belongs to the family of the Flaviviridae. Recently, envelope glycoprotein Erns was identified as an RNase. RNases can express different biological actions. They have been shown to be neurotoxic, antihelminthic, and immunosuppressive. We studied the immunosuppressive properties of Erns in vitro. The glycoprotein totally inhibited concanavalin A-induced proliferation of porcine, bovine, ovine, and human lymphocytes. We then studied the direct cytotoxic effects of Erns on lymphocytes and epithelial cells in protein synthesis assays. Erns strongly inhibited the protein synthesis of lymphocytes of different species, without cell membrane damage. This suggested an apoptotic process, and indeed apoptosis of lymphocytes was detected after incubation with Erns. Pestivirus infections are characterized by leukopenia and immunosuppression. Our results suggest that Erns plays an important role in the pathogenesis of pestiviruses.
LTE in unlicensed spectrum using licensed-assisted access (2014)

It is forecasted that mobile data traffic will increase 1000-fold from 2010 to 2020. As a result, the network must evolve to meet the large and rapidly growing data demand. An effective approach for increasing network capacity is to use additional spectrum. In Rel-13, LTE deployment in unlicensed spectrum is being considered. This feature is called Licensed-Assisted Access (LAA) using LTE. Unlicensed band is attractive due to the large amount of available spectrum. In this paper, we provide an overview of LAA including standardization progress and potential changes. A fairness mechanism for LAA coexistence is also presented. Downlink system performance is analyzed for multi-operator LAA deployment. Three representative scenarios are considered - indoor hotspot, indoor office, and outdoor small cell. It is shown that LAA can offer significant additional capacity to the network. Analysis shows that a co-existence mechanism such as listen-before-talk is needed in co-channel multi-operator deployment to ensure that all users can receive service. With listen-before-talk, co-existence is not an issue even in dense deployment.
Macromol. Chem. Phys. 21/2014 (2014)

Front Cover: Poly(ethylene 2,5-furandicarboxylate) (PEF), an emergent biobased polyester, is produced through direct esterification and polycondensation of purified 2,5-furan-dicarboxylic acid (FDCA), obtained from sugar derived from 1st or 2nd generation feedstocks. In-depth understanding and control over the crystallization process from the melt, as well as from the glass, are of major importance from both the academic standpoint and with regard to obtaining final manufactured products, such as bottles or T-shirts, with desired properties, since fast crystallization from the glassy state is desired for solid-state polycondensation (SSP) and industrial reprocessing, whereas slow crystallization from the melt is desired for injection stretch blow molding of preforms for bottle blowing. Further details can be found in the article by A. Codou, N. Guigo, J. van Berke, E. de Jong, and N. Sbirrazzuoli* on page 2065.
Confidentiality Breach Through Acoustic Side-Channel in Cyber-Physical Additive Manufacturing Systems (2017)

In cyber-physical systems, due to the tight integration of the computational, communication, and physical components, most of the information in the cyber-domain manifests in terms of physical actions (such as motion, temperature change, etc.). This leads to the system being prone to physical-to-cyber domain attacks that affect the confidentiality. Physical actions are governed by energy flows, which may be observed. Some of these observable energy flows unintentionally leak information about the cyber-domain and hence are known as the side-channels. Side-channels such as acoustic, thermal, and power allow attackers to acquire the information without actually leveraging the vulnerability of the algorithms implemented in the system. As a case study, we have taken cyber-physical additive manufacturing systems (fused deposition modeling-based three-dimensional (3D) printer) to demonstrate how the acoustic side-channel can be used to breach the confidentiality of the system. In 3D printers, geometry, process, and machine information are the intellectual properties, which are stored in the cyber domain (G-code). We have designed an attack model that consists of digital signal processing, machine-learning algorithms, and context-based post processing to steal the intellectual property in the form of geometry details by reconstructing the G-code and thus the test objects. We have successfully reconstructed various test objects with an average axis prediction accuracy of 86% and an average length prediction error of 11.11%.
Global phase diagram of bound states in the continuum (2022)

Bound states in the continuum (BICs) in photonic-crystal slabs have been conventionally classified into three types: single-resonance parametric, symmetry-protected, and Friedrich–Wintgen BICs. Here, we show that the single-resonance parametric BICs come from the coupling between the guided resonance (GR) and Fabry–Perot (FP) modes, and the symmetry-protected BICs from the coupling between degenerate GR modes. Hence, the three types of BICs in photonic-crystal slabs can be classified by the three different Friedrich–Wintgen origins. Based on this universal classification, a global phase diagram of BICs can be obtained with each phase identified by the indices of the three different Friedrich–Wintgen-type BICs. When BICs are created or annihilated, a phase transition occurs and is experimentally observed, in which the FP modes play a significant role. Our work shows a clear physical picture on whether BICs exist and how sensitive they are to changes in the parameter space, and enables improvements in experiment design and applications.
Increased expression of IL‐24 in chronic spontaneous urticaria (2019)

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Neurological manifestations of Erdheim–Chester Disease (2020)

In patients with ECD, neurologic morbidity is common and contributes significantly to disability. Since neurologic symptoms can be the presenting feature of ECD and, given the mean delay in ECD diagnosis is 4.2 years, it is critical that neurologists consider of ECD and other histiocytosis in patients with inflammatory, infectious, or neoplastic-appearing white matter. Furthermore, given the broad spectrum of neurologic involvement, neurologists have an important role in a team of specialists treating ECD patients.
Fabrication of Multilayer Pb(Zr0.53Ti0.47)O3 Film Crystallized by Laser Annealing (2013)

Crystallization of Pb(Zr 0.53 Ti 0.47 )O 3 (PZT) films derived from sol–gel precursor solutions using a continuous-wave (CW) 980 nm semiconductor laser is discussed in this paper. By using a 0.3 M precursor solution and repeating 4 times a sequence of drying, pyrolysis, and laser annealing (LA) processes, 150-nm-thick PZT films with (111)-preferred texture are obtained. By adjusting the laser power according to the variation in film thickness, PZT crystallization is induced throughout the film, which is confirmed by electron diffraction patterns. The dielectric constant and loss tangent measured with an oscillation voltage of 0.8 V at 10 kHz are 1200 and 0.078, respectively. The remanent polarization and coercive field of the LA-PZT film are 30 µC/cm 2 and 104 kV/cm, respectively. The field-induced strain property calculated from the voltage-displacement curve obtained by an atomic force microscopy measurement is comparable to that of the PZT film fabricated by rapid thermal annealing.
Role of CD37SMIP a Novel Engineered Small Modular Immunopharmaceutical in the Treatment of CLL. (2007)

Abstract CD37 is a lineage-specific B-cell antigen highly expressed on both normal and transformed B-cells. The significant B-cell selective CD37 expression makes it a valuable target for therapy against B cell malignancies including chronic lymphocytic leukemia (CLL), hairy cell leukemia (HCL), and non-Hodgkins lymphoma (B-NHL). A novel CD37-specific small modular immunopharmaceutical (CD37SMIP) was engineered to contain a single chain variable region (scFv) linked to a human IgG1 hinge, CH2 and CH3 domains. CD37SMIP induces potent apoptosis in the presence of a crosslinker and antibody dependent cellular cytotoxicity (ADCC) against primary CLL cells. Significant in vivo therapeutic efficacy was demonstrated in a SCID mouse xenograft leukemia/lymphoma model that is dependent upon NK cell function. The induced cytotoxicity in primary CLL cells was independent of activation of caspase cascade, and consistent with this, the pan-caspase inhibitor z-VAD-fmk failed to rescue CD37 SMIP drug induced cytotoxicity. In an attempt to define the CD37 mediated early signaling events and their role in cytotoxicity, we investigated protein tyrosine phosphorylation as a potential early activation event responsible for CD37 SMIP drug mediated cytotoxicity. Primary B CLL cells were stimulated with increasing concentration of CD37 SMIP with or without crosslinker. Western blot analysis of cellular lysates with anti-phosphotyrosine antibody revealed several tyrosine phosphorylated proteins including a predominant ∼65KDa protein in response to the cross-linking of CD37 SMIP within 10 minutes. Further, pre-treatment with the tyrosine kinase inhibitor herbimycin prevented tyrosine phosphorylation of the predominant 65KDa protein and inhibited CD37 SMIP induced apoptosis in a dose dependent manner. Attempts to identify the tyrosine phosphorylated proteins, using MALDI-TOF mass spectrometry, and to define the potential role of these target proteins in the apoptotic pathway are ongoing. To further examine the molecular mechanism whereby CD37 SMIP triggers cell death, we investigated the involvement of mitochondrial pathways including changes in mitochondrial potential (Δψm) and generation of reactive oxygen species. Treatment with CD37 SMIP induces a time dependent mitochondrial membrane depolarization and increased production of ROS. Further, primary B CLL cells cultured with CD37SMIP induced cleavage and mitochondrial translocation of Bax and upregulation of Bim in a time dependent manner indicating a potential role for Bim and Bax pro apoptotic proteins in CD37 induced apoptosis. These findings provide strong justification for CD37 as a therapeutic target aimed at modulation of pro apoptotic proteins and introduce small modular immunopharmaceuticals as a novel class of targeted therapies for B-cell malignancies. (SMIP trademark is owned by Trubion Pharmaceuticals).
ChemInform Abstract: A Hybrid Electrochemical/Chemical Synthesis of Supported, Luminescent Cadmium Sulfide Nanocrystals. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Temporal residual data sub-sampling in LDV representation format (2010)

The paper presents an analysis on temporal residual data sub-sampling in the layered depth video format (LDV). First, the LDV format with main view and residual views or data is introduced. Then, the extraction of residual data is presented and its block wise alignment for better coding efficiency. Next, the temporal residual data sub-sampling is shown together with an advanced merging method prior to sub-sampling for preserving the necessary information for good view synthesis results. These synthesis results are shown for intermediate views, generated from the uncoded, as well as coded LDV data with different temporal sub-sampling factors and merging methods for the residual data. The results show, that temporal residual data sub-sampling with data merging can outperform regular LDV without sub-sampling for the coded and uncoded versions.
Advanced visual analytics interfaces for adverse drug event detection (2014)

Adverse reactions to drugs are a major public health care issue. Currently, the Food and Drug Administration (FDA) publishes quarterly reports that typically contain on the order of 200,000 adverse incidents. In such numerous incidents, low frequency events that are clinically highly significant often remain undetected. In this paper, we introduce a visual analytics system to solve this problem using (1) high scalable interfaces for analyzing correlations between a number of complex variables (e.g., drug and reaction); (2) enhanced statistical computations and interactive relevance filters to quickly identify significant events including those with a low frequency; and (3) a tight integration of expert knowledge for detecting and validating adverse drug events. We applied these techniques to the FDA Adverse Event Reporting System and were able to identify important adverse drug events, such as the known association of the drug Avandia with myocardial infarction and Seroquel with diabetes mellitus, as well as low frequency events such as the association of Boniva with femur fracture. In our evaluation, we found over 90% of the adverse drug events that were published in the Institute for Safe Medication Practices (ISMP) reports from 2009 to 2012. In addition, our domain expert was able to identify some previously unknown adverse drug events.
[124I]FIAU: Human dosimetry and infection imaging in patients with suspected prosthetic joint infection (2016)

[(124)I]FIAU was well-tolerated in healthy volunteers and subjects with suspected PJI, and had acceptable dosimetry. However, the utility of [(124)I]FIAU for the clinical detection of PJIs is limited by poor image quality and low specificity.
Studies of Vulcanizing Agent and Vulcanization Accelerator, Part 8. Vulcanization of Halogen-Containing Rubber with Cyclohexasulfide. (2000)

7-n-Butylamino-7-phenyl-8-thioxo-1, 2, 3, 4, 5, 6-hexa thiocane(BPTH) derivative has been prepared by treating p-substituted acetophenon, n-butyl or n-propyl amine and sulfur. The vulcanization in the presence of BPTH has been investigated for examining the ability of BPTH as valcanizing agent for NR, CR and halogen containg rubber, as compared to commomly used vulcanizing agents. BPTH was found to give good vulcanized rubber without using any vulcanization acceleators. The apparent characteristic feature of the vulcanization is disulfide type crosslinking and low free sulfur. For CR the apparent charactristic feature of the vulcanization has good heat resistance as well as EU and effect of substitute by active parameter did not find. But crosslinking was found to occur at thio-keton base and cyclohexasulfide base. More, BPTH was found to be effective as vulcanizing agent for CO, CM, ACM.
Neocortical Circuit Interrogation with Optogenetics (2013)

Optogenetic tools have gained popularity for enabling manipulation of specified populations of neurons on a precise temporal scale. These opsins, as the proteins are known, utilize retinal (Vitamin A) as a co-factor—in a form related to the same molecule used by the human retina as a light-sensing moiety; opsin function does not require (at least in vertebrates) exogenous supplementation of this molecule [1]. Taken together, these properties of optogenetic tools situate them ideally for the interrogation of neural circuits in the settings of acute slice preparations, in vivo single and multiunit recordings, and behaving animals. Robust and diverse tools now exist to allow for both gain and loss of function experiments in all of these settings; for example, recent engineering and genomic approaches have introduced diversity in the spectral properties of both excitatory and inhibitory opsins, opening the door to combinatorial optogenetic experiments and simultaneous manipulation of multiple populations of neurons in the same physical volume [2] (see Chapter 5 in this volume). Here we discuss circuit-targeting strategies with examples from the recent literature, focusing particularly on approaches and results in the study of mammalian neocortex.
Supplementary Figure Legends from The Novel Tryptamine Derivative JNJ-26854165 Induces Wild-Type p53- and E2F1-Mediated Apoptosis in Acute Myeloid and Lymphoid Leukemias (2023)

Supplementary Figure Legends from The Novel Tryptamine Derivative JNJ-26854165 Induces Wild-Type p53- and E2F1-Mediated Apoptosis in Acute Myeloid and Lymphoid Leukemias
Relationship between heart rate variability and pulse wave velocity and their association with patient outcomes in chronic kidney disease (2020)

Background: Arterial stiffness and low heart rate variability (HRV) have each been associated with increased cardiovascular risk in a variety of patient populations. We explored the relationship between HRV and pulse wave velocity (PWV measure of arterial stiffness) in patients with chronic kidney disease (CKD prior to ESRD) along with examining their association with the outcomes of cardiovascular disease (CVD), death, and progression to end stage renal disease (ESRD). Methods: The RRI-CKD Study is a 4-center prospective cohort study of CKD stages 3 – 5 (n = 834). A subset underwent both HRV testing by 24-hour Holter and carotid-femoral PWV (n = 240). Multiple linear regression was used to assess predictors of PWV and Cox regression to investigate the association of HRV and PWV with time to first CVD event or death and ESRD. Results: Although several HRV measures were inversely correlated with PWV, this association was attenuated after adjustment for age and/or diabetes and no longer significant after adjustment for C-reactive protein. Low HRV and high PWV were individually associated with increased risk of the composite endpoint of CVD/death in multivariable analysis. The risk of the composite of CVD/death was highest for patients with both low HRV and high PWV. Conclusion: Age, diabetes, and inflammation together explained the inverse association between HRV and PWV. Inflammation may play a role in the pathogenesis of both low HRV and high PWV. The combination of low HRV and high PWV showed the strongest association with a composite CVD outcome. Mechanisms underlying abnormalities in PWV and HRV, and the role of these measures as intermediate outcomes in future trials in CKD patients, merit further study.
Teacher Profile and Factors Impacting Teacher Technology Use: A Practical Investigation (2022)

This work aims to understand teachers’ use of technology, their profiles, planning process and maturity of technology use. 15 teachers in different contexts were interviewed to understand what tools they are using, as well as why and how they were used. Data have shown that this use is still in the first stages of maturity. Teachers’ personal skills, experience with technology and circumstances at their workplace had an impact on this result.
4-Alkyloxyimino-cytosine nucleotides: tethering approaches to molecular probes for the P2Y6 receptor (2021)

4-Alkyloxyimino derivatives of pyrimidine nucleotides display high potency as agonists of certain G protein-coupled P2Y receptors (P2YRs). In an effort to functionalize a P2Y6R agonist for fluorescent labeling, we probed two positions (N4 and γ-phosphate of cytidine derivatives) with various functional groups, including alkynes for click chemistry. Functionalization of extended imino substituents at the 4 position of the pyrimidine nucleobase of CDP preserved P2Y6R potency generally better than γ-phosphoester formation in CTP derivatives. Fluorescent Alexa Fluor 488 conjugate 16 activated the human P2Y6R expressed in 1321N1 human astrocytoma cells with an EC50 of 9 nM, and exhibited high selectivity for this receptor over other uridine nucleotide-activated P2Y receptors. Flow cytometry detected specific labeling with 16 to P2Y6R-expressing but not to wild-type 1321N1 cells. Additionally, confocal microscopy indicated both internalized 16 (t1/2 of 18 min) and surface-bound fluorescence. Known P2Y6R ligands inhibited labeling. Theoretical docking of 16 to a homology model of the P2Y6R predicted electrostatic interactions between the fluorophore and extracellular portion of TM3. Thus, we have identified the N4-benzyloxy group as a structurally permissive site for synthesis of functionalized congeners leading to high affinity molecular probes for studying the P2Y6R.