gebhart/patrepeval huggingface dataset:
3‐(4‐Carboxybenzoyl)quinoline‐2‐carboxaldehyde labeling for direct analysis of amino acids in plasma is not suitable for simultaneous quantification of tryptophan, tyrosine, valine, and isoleucine by CE/fluorescence (2021)

Capillary electrophoresis coupled to LED-induced fluorescence detection is a robust and sensitive technique used for amino acids (AA) analysis in biological media, after labeling with 3-(4-carboxybenzoyl)quinoline-2-carboxaldehyde (CBQCA). We wanted to quantitate in plasma tryptophan (Trp), tyrosine (Tyr), valine (Val), and isoleucine (Ile). Among the different labeled AA-CBQCA, Trp has the lowest fluorescence yield, which makes its detection and quantification very difficult in biological samples such as plasma. We tried to improve Trp analysis by CE/LED-induced fluorescence detection to its maximal sensitivity by using large volume sample stacking as a preconcentration step in our analytical protocol. At pH 9.5, this step caused a drop in resolution during the separation of the four AAs and it was therefore necessary to work at pH 10. We have found that Tyr, Val, Ile, and Trp are detected and well separated from the other AAs, but Trp cannot be quantified in plasma samples, mainly because of the low fluorescence yield of the Trp-CBQCA derivative. The recorded LOD is 0.18 μM for Trp-CBQCA in standard solution with a resolution between Trp and Tyr of 1.2, while the LOD is 6 μM in plasma with the same resolution. Trp, Tyr, Val, and Ile are, however, efficiently quantified when using a 3 M acetic acid electrolyte and CE associated with capacitively coupled contactless conductivity detection, which also has the advantage of not requiring derivatization or large volume sample stacking. This article demonstrates, for the CE user, that quantitative analysis of these four AA in mouse plasma can be performed by CE-fluorescence after CBQCA labeling, with the exception of Trp. It can be advantageously replaced by CE/capacitively coupled contactless conductivity detection, the only efficient one for Trp, Tyr, Val, and Ile quantification. In this case, the LOD for Trp is 2 μM. The four AAs are separated with resolution with neighbors above 1.5.
Performance Evaluation of III-V Nanowire Broken-Gap TFETs Including Electron-Phonon Scattering Using an Atomistic Mode Space NEGF Technique Enabling Million Atoms NW Simulations. (2017)

2017 International Conference on Solid State Devices and Materials,Performance Evaluation of III-V Nanowire Broken-Gap TFETs Including Electron-Phonon Scattering Using an Atomistic Mode Space NEGF Technique Enabling Million Atoms NW Simulations.
Organorhenium Oxides (1997)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganorhenium Oxides†Wolfgang A. Herrmann and Fritz E. KühnView Author Information Anorganisch-chemisches Institut der Technischen Universität München, Lichtenbergstrasse 4, D-85747 Garching b. München, GermanyCite this: Acc. Chem. Res. 1997, 30, 4, 169–180Publication Date (Web):April 15, 1997Publication History Received20 September 1996Published online15 April 1997Published inissue 1 April 1997https://pubs.acs.org/doi/10.1021/ar9601398https://doi.org/10.1021/ar9601398research-articleACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views1712Altmetric-Citations296LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Ligands,Molecules,Oxidation,Oxides,Reaction products Get e-Alerts
Development and in vivo Demonstration of CMOS-Based Multichip Retinal Stimulator With Simultaneous Multisite Stimulation Capability (2010)

A complementary metal-oxide semiconductor (CMOS)-based multichip flexible neural stimulator for retinal prostheses was developed. The multichip retinal stimulator is capable of simultaneous multisite stimulation. An on-chip stimulation generator was implemented on the "unit chip," which is the core device of the multichip retinal stimulator. The performance of the CMOS circuitry was characterized. A new device structure and packaging process was developed. The in vivo retinal stimulation on a rabbit's retina was successfully performed and the multisite stimulation functionality was confirmed.
Non-Coulombic frictional drag currents in coupled LaAlO 3 /SrTiO 3 nanowires (2017)

Frictional drag phenomena are investigated in coupled nanowires formed at LaAlO$_3$/SrTiO$_3$ heterointerfaces. The weak decay of drag resistance with increasing wire separation rules out Coulomb interactions as the coupling mechanism. The observed unidirectional current drag is explained using a simple model that invokes slight asymmetries within the nanowires. These results provide new insights into non-Coulombic electron-electron interaction effects that must be accounted for in any full description of electron transport at oxide interfaces.
Chemokine Receptor CCR1 Regulates Inflammatory Cell Infiltration after Renal Ischemia-Reperfusion Injury (2008)

Neutrophils and macrophages rapidly infiltrate the kidney after renal ischemia-reperfusion injury, however specific molecular recruitment mechanisms have not been fully delineated for these cell types. Here we provide genetic and pharmacologic evidence supporting a positive role for the chemokine receptor CCR1 in macrophage and neutrophil infiltration in a 7 day mouse model of renal ischemia-reperfusion injury. By day 7, injured kidneys from mice lacking CCR1 contained 35% fewer neutrophils and 45% fewer macrophages than injured kidneys from wild-type control mice. Pretreatment of wild-type mice with the specific CCR1 antagonist BX471 also suppressed neutrophil and macrophage infiltration in the model. Injured kidneys from mice lacking CCR1 also had reduced content of the CCR1 ligands CCL3 (MIP-1alpha) and CCL5 (RANTES) compared with injured kidneys from wild-type controls, suggesting a leukocyte source for these inflammatory chemokines and existence of a CCR1-dependent positive feedback loop for leukocyte infiltration in the model. Local leukocyte proliferation and apoptosis were detected after injury, but were not dependent on CCR1. Also, the extent of necrotic and fibrotic damage and decline in renal function in injured kidneys was similar in wild-type and CCR1-deficient mice. Thus, CCR1 appears to regulate trafficking of macrophages and neutrophils to kidney in a mouse model of renal ischemia-reperfusion injury, however this activity does not appear to affect tissue injury.
Characterization and Genetic Mapping of Black Root Rot Resistance in Gossypium arboreum L. (2021)

Black root rot (BRR) is an economically important disease of cotton and other crops, especially in cooler regions with short growing seasons. Symptoms include black discoloration of the roots, reduced number of lateral roots and stunted or slow plant growth. The cultivated tetraploid Gossypium species are susceptible to BRR. Resistance to BRR was identified in <i>G. arboreum</i> accession BM13H and is associated with reduced and restricted hyphal growth and less sporulation. Transcriptome analysis indicates that BM13H responds to infection at early time points 2- and 3-days post-inoculation, but by day 5, few differentially expressed genes are observed between infected and uninfected roots. Inheritance of BM13H resistance to BRR was evaluated in an F<sub>6</sub> recombinant inbred population and shows a single semi-dominant locus conferring resistance that was fine mapped to a region on chromosome 1, containing ten genes including five putative resistance-like genes.
Organosilica Nanoparticles for Gemcitabine Monophosphate Delivery in Cancer Cells (2019)

Abstract Organosilica nanoparticles hold great promise for nanomedicine applications. These nanoparticles are synthesized from polytrialkoxysilylated precursors without any silica source. In this work we present two kinds of organosilica nanoparticles with either amine or ammonium walls constituting their structure. Both types of nanoparticles are very efficient for gemcitabine monophosphate delivery, a small hydrophilic anticancer drug whose encapsulation is still a challenge. The nanoparticles are endocytosed by MCF‐7 breast cancer cells as monitored by confocal microscopy. They are efficient and lead to 60% cancer cell death.
Improved luminescence quality with an asymmetric confinement potential in Si-based type-II quantum wells grown on a graded SiGe relaxed buffer (1996)

A new class of Si-based quantum confined geometry is demonstrated using a combination of oppositely strained layers grown on a step-graded relaxed SiGe buffer. The role of heterointerfaces is revealed as the controlling mechanism of the exciton localization, which results in enhanced no-phonon transition intensity.
Introduction (2008)

We have been living with influenza as long as history can remember, and we are so used to the fact that this disease is part of life that we usually do not pay much attention to it. Even the science of influenza virus has been dormant for more than half a century. After the excitement of the initial discovery of the virus in 1933 and the development of the first vaccines by growing the virus in the allantoic cavity of embryonated hen’s eggs in the 1940s, relatively little has happened in the field: development of the first serological assays, definition of some serological correlates of protection, and little more. There was no real breakthrough until the application of reverse genetics and of novel adjuvant technology to the field. Somehow people thought that the influenza problem had been solved or was not a problem, very little money was available for research. Worldwide only a few laboratories continued to perform research on influenza. Vaccine manufacturers had no incentive to invest in improved influenza vaccines because the low price and the limited market did not justify investments in new technologies. When the 21st century arrived, with every single field was celebrating technological quantum jumps, and the excitements of the human genome permeating the globe, influenza was still happy to use the technologies of 1940s, complacent with the status quo.
SLC43A3 Is a Biomarker of Sensitivity to the Telomeric DNA Damage Mediator 6-Thio-2′-Deoxyguanosine (2020)

Cell membrane transporters facilitate the passage of nucleobases and nucleosides for nucleotide synthesis and metabolism, and are important for the delivery of nucleoside analogues used in anticancer drug therapy. Here, we investigated if cell membrane transporters are involved in the cellular uptake of the nucleoside analogue DNA damage mediator 6-thio-2'-deoxyguanosine (6-thio-dG). A large panel of non-small cell lung cancer (NSCLC) cell lines (73 of 77) were sensitive to 6-thio-dG; only four NSCLC lines were resistant to 6-thio-dG. When analyzed by microarray and RNA sequencing, the resistant NSCLC cell lines clustered together, providing a molecular signature for patients that may not respond to 6-thio-dG. Significant downregulation of solute carrier family 43 A3 (<i>SLC43A3</i>), an equilibrative nucleobase transporter, was identified as a candidate in this molecular resistance signature. High levels of <i>SLC43A3</i> mRNA predicted sensitivity to 6-thio-dG and therefore <i>SLC43A3</i> could serve as a promising biomarker for 6-thio-dG sensitivity in patients with NSCLC. SIGNIFICANCE: These findings identify a biomarker of resistance to the telomeric DNA damage mediator 6-thio-2'-deoxyguanosine.
Toward Creation of a Universal NMR Database for Stereochemical Assignment:  Complete Structure of the Desertomycin/Oasomycin Class of Natural Products (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTToward Creation of a Universal NMR Database for Stereochemical Assignment: Complete Structure of the Desertomycin/Oasomycin Class of Natural ProductsYoshihisa Kobayashi, Choon-Hong Tan, and Yoshito KishiView Author Information Department of Chemistry and Chemical Biology Harvard University, 12 Oxford Street Cambridge, Massachusetts 02138 Cite this: J. Am. Chem. Soc. 2001, 123, 9, 2076–2078Publication Date (Web):February 10, 2001Publication History Received4 December 2000Published online10 February 2001Published inissue 1 March 2001https://pubs.acs.org/doi/10.1021/ja004154qhttps://doi.org/10.1021/ja004154qrapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views1976Altmetric-Citations78LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alkyls,Biological databases,Degradation,Organic compounds,Stereochemistry Get e-Alerts
Impact of Autonomic Regulation Therapy in Patients with Heart Failure (2019)

URL: http://www.clinicaltrials.gov. Unique identifier: NCT03425422.
The Effect of Obesity on Direct Medical Costs in Total Knee Arthroplasty (2014)

Obesity is associated with longer hospital stays and higher costs in total knee arthroplasty. The effect of obesity on costs appears to be independent of obesity-related comorbid conditions and complications.
Structural and Compositional Characteristicsof Canaryseed (Phalaris canariensisL.) (1997)

Canaryseed (Phalaris canariensis L.) has small elliptical grains with hulls, which are covered with very fine silicious spicules that are severe skin irritants and potentially carcinogenic. Because chemical treatments and a glabrous genotype are now available for eliminating the spicules, the chemical composition of the dehulled groat was determined to evaluate its potential food and industrial applications. Canaryseed groats contained 61.0% starch, which comprised small polygonal granules with diameters of 1.5−3.5 μm. The groats averaged 18.7% protein compared to 15.0% in wheat, and the proportions of prolamin and glutelin in the protein averaged 77.7%, exceeding that in the control wheat protein of 73.5%. Canaryseed proteins were more deficient in lysine and threonine than wheat proteins but were very rich in cystine, tryptophan, and phenylalanine. For a cereal, canaryseed groats were very high in crude fat, 8.7%, and purified total lipid, 11.0%, containing 55% linoleic, 29% oleic, 11% palmitic, and 2.5% linolenic acids. The groat and roller-milled flours were low in dietary fiber, soluble sugars, and total ash. The composition of small granule starch and gluten-like proteins, rich in tryptophan, suggests unique functional and nutritional properties for canaryseed groats. Keywords: Canaryseed; seed morphology; composition; amino acids; protein fractions; fatty acids; sugars
Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional Bacillus Calmette–Guérin followed by Ipilimumab in Patients with Advanced Metastatic Melanoma (2018)

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced melanoma. The first ICI to demonstrate clinical benefit, ipilimumab, targets cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4); however, the long-term overall survival is just 22%. More than 40 years ago intralesional (IL) <i>bacillus Calmette-Guérin</i> (BCG), a living attenuated strain of <i>Mycobacterium bovis</i>, was found to induce tumor regression by stimulating cell-mediated immunity following a localized and self-limiting infection. We evaluated these two immune stimulants in combination with melanoma with the aim of developing a more effective immunotherapy and to assess toxicity. In this phase I study, patients with histologically confirmed stage III/IV metastatic melanoma received IL BCG injection followed by up to four cycles of intravenous ipilimumab (anti-CTLA-4) (ClinicalTrials.gov number NCT01838200). The trial was discontinued following treatment of the first five patients as the two patients receiving the escalation dose of BCG developed high-grade immune-related adverse events (irAEs) typical of ipilimumab monotherapy. These irAEs were characterized in both patients by profound increases in the repertoire of autoantibodies directed against both self- and cancer antigens. Interestingly, the induced autoantibodies were detected at time points that preceded the development of symptomatic toxicity. There was no overlap in the antigen specificity between patients and no evidence of clinical responses. Efforts to increase response rates through the use of novel immunotherapeutic combinations may be associated with higher rates of irAEs, thus the imperative to identify biomarkers of toxicity remains strong. While the small patient numbers in this trial do not allow for any conclusive evidence of predictive biomarkers, the observed changes warrant further examination of autoantibody repertoires in larger patient cohorts at risk of developing irAEs during their course of treatment. In summary, dose escalation of IL BCG followed by ipilimumab therapy was not well tolerated in advanced melanoma patients and showed no evidence of clinical benefit. Measuring autoantibody responses may provide early means for identifying patients at risk from developing severe irAEs during cancer immunotherapy.
Sustainable electrocatalytic water treatment : considering the use of earth-abundant materials for nitrate remediation. (2020)

International audience
Clinical trial protocol for TARDOX: a phase I study to investigate the feasibility of targeted release of lyso-thermosensitive liposomal doxorubicin (ThermoDox®) using focused ultrasound in patients with liver tumours (2017)

ClinicalTrials.gov Identifier: NCT02181075, Edura-CT Identifier: 2014-000514-61.Ethics Number: 14/NE/0124.
2 in 1 leakey coaxial cable for intrusion detection sensor (2013)

Novel leaky coaxial cable (LCX) is developed. It contains both transmitting and receiving LCX for intrusion detection sensor. While the suppression of coupling between transmitter and receiver is major theme in microwave technology, we give a solution of transmitter and receiver antenna combination. We have developed a prototype of 2 in 1 LCX and then evaluated its performance for intrusion detection sensor in field experimentation.
Construction of a recombinant bacterial plasmid containing pro-alpha 1(I) collagen DNA sequences. (1980)

A partially purified mRNA preparation enriched for chick collagen messenger RNA activity was used as template for the synthesis of double stranded cDNA. The cDNA was ligated into the HindIII site of the plasmid vector pBR322 and used to transform Escherichia coli x1776. One plasmid with an 800-base pair insert was shown to contain DNA sequences corresponding to Type I pro-alpha 1 collagen.
April 2016 Ecuador Earthquake of Moment Magnitude M<sub>w</sub>7.8: Overview and Damage Report (2017)

The northern coastal region of Ecuador was affected by a moment magnitude M w 7.8 strong earthquake on April 16, 2016, with a recorded PGA of 1.41 g close to the epicenter. The earthquake was named “Pedernales” because the epicenter was near this small town located in the coastal province of Manabí, with a hypocentral depth of 21 km. Two strong aftershocks of M w 6.7 and M w 6.9 were felt a month later and they continued the destruction caused by the main event. Ecuador is located in a seismic zone with a long history of major earthquakes that have caused a lot of destruction in the last six centuries, the main seismic source comes from the subduction of the Nazca Plate under the South American Plate, but there are also crustal earthquakes and volcanism on the Andes Mountains that cross the country from north to south. In the northern coastal province of Esmeraldas a powerful earthquake of moment magnitude M w 8.8 was recorded in 1906, with a rupture area that has caused strong earthquakes in the 20 th and 21 st centuries. This paper describes the seismological aspects and the recorded strong ground motions, the geotechnical and infrastructure performance, site amplification and liquefaction on a few places, structural damage and collapse of buildings, extensive non-structural damage (mainly large damage to masonry walls) at high-rise buildings in cities near (100 km) and far away (270 km) from the epicenter, due to local soil conditions and flexible framed reinforced concrete structures.