gebhart/patrepeval huggingface dataset:
HYGAS coal-slurry mass-flow measurements using ultrasonic cross-correlation techniques (1979)

The application of ultrasonic techniques to measure coal concentration and flow velocity of coal slurries was investigated at the HYGAS pilot plant. It was found that the sound attenuation is linearly dependent on the coal concentration up to 35% by weight, and provides a direct measurement of the coal concentration with a precision of 5%. An active cross-correlation technique using an amplitude demodulation scheme can measure the flow velocity of the coal slurry with a resolution of 3%. Flow disturbances in the coal slurry, which are received by transducers separated by 12.7 cm and the cross-correlation have frequency contents primarily in the range of 20 to 50 Hz. Based on the results of the calibration test, an on-line ultrasonic mass flowmeter is proposed which measures the coal concentration based on the sound attenuation in the coal slurry and the flow velocity by means of an active cross-correlation technique.
DICTIONARY OF THE ECONOMIC PRODUCTS OF INDIA pages 297 to 318 (2014)

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Circulating tumor DNA (ctDNA) in nonmetastatic colorectal cancer (CRC): Potential role as a screening tool. (2015)

518 Background: CRC screening significantly reduces cancer incidence and mortality. Participation rates in screening, both stool based and endoscopic, are often low. The value and safety of endoscopic screening in older individuals is also uncertain. Preliminary data indicate ctDNA can be detected in a high proportion of patients with early stage CRC, suggesting promise as a screening test that should have broad community acceptance. Methods: Plasma samples were collected at diagnosis from 100 patients (pts) with newly diagnosed CRC. Surgical, clinicopathologic and outcome data were prospectively captured. All samples were sent to Johns Hopkins Kimmel Cancer Center, where tumors were sequenced using a panel of 15 genes frequently mutated in CRC to identify candidate mutations for ctDNA analysis. For each pt, one tumor mutation was selected to assess for ctDNA in plasma samples using the Safe-SeqS digital genomic assay. Results: Preliminary data is available on 68 pts. Median follow-up is 15.2 months. Candidate mutations for ctDNA analysis were identified in all cases, with a matching mutation detectable in the plasma cell-free DNA in 41 pts (60%). Median mutant allele fraction was 0.24% (range 0.11% - 8.39%). Tumor stage did not appear to have a major impact on the detection rate of ctDNA (Table), and ctDNA detection was independent of CEA levels. Five pts have recurred, all of whom had detectable ctDNA at diagnosis, whereas CEA was elevated in only 1 of these cases. Conclusions: Preliminary data suggests ctDNA is detectable at diagnosis in the majority of pts with non-metastatic CRC. The potential for ctDNA as a CRC screening tool, and as a prognostic marker for patients with early stage cancer, should be further explored. [Table: see text]
Quantum advantage for computations with limited space (2020)

Quantum computations promise the ability to solve problems intractable in the classical setting. Restricting the types of computations considered often allows to establish a provable theoretical advantage by quantum computations, and later demonstrate it experimentally. In this paper, we consider space-restricted computations, where input is a read-only memory and only one (qu)bit can be computed on. We show that $n$-bit symmetric Boolean functions can be implemented exactly through the use of quantum signal processing as restricted space quantum computations using $O(n^2)$ gates, but some of them may only be evaluated with probability $1/2 + O(n/\sqrt{2}^n)$ by analogously defined classical computations. We experimentally demonstrate computations of $3$-, $4$-, $5$-, and $6$-bit symmetric Boolean functions by quantum circuits, leveraging custom two-qubit gates, with algorithmic success probability exceeding the best possible classically. This establishes and experimentally verifies a different kind of quantum advantage -- one where quantum scrap space is more valuable than analogous classical space -- and calls for an in-depth exploration of space-time tradeoffs in quantum circuits.
The Substance P Receptor Is Necessary for a Normal Granulomatous Response in Murine Schistosomiasis Mansoni (1999)

Immune cells within the granulomas of murine schistosomiasis mansoni make the neuropeptide substance P (SP) and express neurokine 1 receptor, which is the specific receptor for substance P (SPr). It was determined if mice with deletion of the SPr (SPr-/-) would develop a normal granulomatous response to schistosome ova during the course of natural infection. Mean liver granuloma size was smaller in SPr-/- mice compared with that of wild-type control animals. Although flow analysis revealed little difference in the cellular composition of the granulomas, both splenocytes and granuloma cells from SPr-/- mice produced much less IFN-gamma and IgG2a and less IgE. The expression of Th2 cytokines (IL-4/IL-5) and IgG1 was comparable to the wild-type control. The mouse with targeted disruption of its SPr had the nonmammalian gene encoding the enzyme beta-galactosidase inserted in exon 1 of the SPr gene. There was beta-galactosidase activity in many mononuclear cells scattered throughout the schistosome granulomas of SPr-/- mice. Also, a granuloma T cell line derived from this transgenic mouse produced beta-galactosidase. These results provide further evidence that in murine schistosomiasis SPr is displayed commonly on granuloma inflammatory cells and is important for granuloma development and expression of IFN-gamma circuitry in this natural infection.
Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embryonal rhabdomyosarcoma cells (2017)

Taken together, our data suggest that altered EPH signalling plays a key role in ERMS development and that its pharmacological inhibition might represent a potential therapeutic strategy to impair stemness and to rescue myogenic program in ERMS cells.
Glenoid Bone-Grafting in Revision to a Reverse Total Shoulder Arthroplasty (2015)

Although there were relatively high rates of glenoid loosening and reoperation at mid-term follow-up, glenoid reconstruction with bone graft in the revision setting was able to relieve pain and restore shoulder function and stability.
Polarization Gratings: A Novel Polarimetric Component for Astronomical Instruments (2010)

Polarization gratings (PGs) have been recently been developed for ultraefficient liquid crystal displays, nonmechanical optical beam steering, and telecommunication devices at optical and near-infrared wavelengths (0.4-2.0 μm). A PG simultaneously acts as both a spectroscopic and polarimetric disperser for circularly polarized light. With the use of a quarter-wave retarder (or analog) to convert linearly to circularly polarized light, these devices can be used as linear polarimetric analyzers. PGs offer high throughput and high levels of birefringence and can currently be constructed inexpensively to diameters of 150 mm, and development projects are in progress to double that size. In this article we report on the characterization of a PG sample at mid-infrared wavelengths (2-40 μm), including the birefringence, throughput, spectral response, and cold cycling survivability. We discuss these devices in the context of astronomical polarimetry, especially as the polarimetric components for a conceptual study of a SOFIA-based polarimeter. © 2010. The Astronomical Society of the Pacific.
A soxRS -Constitutive Mutation Contributing to Antibiotic Resistance in a Clinical Isolate of Salmonella enterica (Serovar Typhimurium) (2001)

The soxRS regulon is activated by redox-cycling drugs such as paraquat and by nitric oxide. The >15 genes of this system provide resistance to both oxidants and multiple antibiotics. An association between clinical quinolone resistance and elevated expression of the soxRS regulon has been observed in Escherichia coli, but this association has not been explored for other enteropathogenic bacteria. Here we describe a soxRS-constitutive mutation in a clinical strain of Salmonella enterica (serovar Typhimurium) that arose with the development of resistance to quinolones during treatment. The elevated quinolone resistance in this strain derived from a point mutation in the soxR gene and could be suppressed in trans by multicopy wild-type soxRS. Multiple-antibiotic resistance was also transferred to a laboratory strain of S. enterica by introducing the cloned mutant soxR gene from the clinical strain. The results show that constitutive expression of soxRS can contribute to antibiotic resistance in clinically relevant S. enterica.
Noise Reduction and Image Enhancement Algorithms for Low-Dose X-Ray Fluoroscopy. (1996)

this paper we describe several filtering techniques for the reduction of quantum noise in low-dose X-ray images, specifically X-ray fluoroscopy images. Quantum noise occurs inherently in low-dose X-ray imaging due to the very low X-ray quantum counts. As a dynamic imaging modality, both temporal and spatial filters can be applied to fluoroscopy. After describing our quantum noise model, we first develop a new motion-adaptive temporal filter based on a recursive structure. Compared to other motion-adaptive filters, our filter is much less prone to generate artefacts known as noise tails. We then describe spatial filtering techniques derived from the concept of spectral amplitude estimation. These filters work in the spectral domain, and can conveniently be tailored to the statistical properties of quantum noise. The noise reduction performance of these filters is evaluated qualitatively as well as quantitatively
Switching Picture Added Scalable Video Coding and its Application for Video Streaming Adaptive to Dynamic Network Bandwidth (2008)

Transmission of video over Internet or wireless network requires coded stream capable of adapting to dynamic network conditions instantly. To meet this requirement, various scalable video coding schemes have been developed, among which the Scalable Video Coding (SVC) extension of the H.264/AVC is the most recent one. In comparison with the scalable profiles of previous video coding standards, the SVC achieves significant improvement on coding efficiency performance. For adapting to dynamic network bandwidth, the SVC employs inter-layer switching between different temporal, spatial or/and fidelity layers, which is currently supported with instantaneous decoding refresh (IDR) access unit. However, for real-time adaptability, the SVC has to frequently employ the IDR picture, which dramatically decreases the coding efficiency. Therefore, an extension of SP picture from the AVC to the SVC for an efficient inter-layer switching is investigated and presented in this paper. Simulations regarding the adaptability to dynamic network bandwidth are implemented. Results of experiment show that the SP picture added SVC provides an average 1.2 dB PSNR enhancement over the current SVC while providing similar adaptive functionality.
Random Beacon for Privacy and Group Security (2008)

Most contemporary security mechanisms and protocols include exchange of random or time-variant nonces as an essential means of protection against replay and other threats or as a seed for randomness. In many cases, it would be beneficial to have such nonces available from a trusted common source, such as a satellite. The goal of this paper is to present a protocol by which a loosely connected network of devices can agree on a common piece of randomness, and show how it can be applied to improve efficiency of a privacy protection system and group session key exchange for PAN/LAN devices.
Variability among Cryptosporidium parvum genotype 1 and 2 immunodominant surface glycoproteins (2002)

Published genomic differences between Cryptosporidium parvum genotype 1 (human-derived) and genotype 2 (animal and human-derived) isolates suggest that these may belong to two distinct species. This is of significant interest since genotype 1 isolates are associated with sporadic cases of human cryptosporidiosis in 30-40 % of cases in contrast to 60-70 % of cases caused by genotype 2. The lower genetic sequence similarity between genotype 1 and 2 surface glycoproteins (gp40/15) suggests that antigenic differences should also occur, a feature that was investigated in this study. Using immune and convalescent serum samples from gnotobiotic piglets previously inoculated with genotype 1 and 2 isolates, we demonstrated that C. parvum gp15 was immunodominant for both genotype 1 and 2 isolates. Lower genetic sequence similarity between genotype 1 and 2 Cpgp40/15 did correspond to gp15 protein differences as detected by Western blot. Moreover, we confirmed that gp15 contains epitopes that are also immunodominant. Deglycosylation of C. parvum proteins resulted in decreased ability of gp15, gp23 and gp900 to react with homologous polyclonal antibodies, suggesting that these proteins also express carbohydrate epitopes. Taken together, our data suggest that there is a high phenotypic variability between C. parvum genotype 1 and 2 isolates at the level of gp15. We contemplate that gp15 surface glycoprotein plays an important role in the biology of C. parvum as a potent inducer of immune response and a possible virulence factor.
Genetic Association Study of Endothelin-1 and Its Receptors EDNRA and EDNRB in Migraine with Aura (2009)

The effect of endothelin-1 and its receptors EDNRA and EDNRB in migraine with aura (MA) susceptibility is not established yet. We studied the association between the MA end-diagnosis and three migraine trait components and 32 single nucleotide polymorphisms (SNPs) capturing the variation of endothelin genes in 850 Finnish migraine patients and 890 non-migrainous individuals. The SNPs showing evidence of association were further studied in 648 German migraine patients and 651 non-migrainous individuals. No significant association was detected. However, the homozygous minor genotype (5% in cases) of the EDNRA SNP rs2048894 showed nominal association with MA both in the Finnish sample (P = 0.015) and in the pooled sample [odds ratio (OR) 1.61, 95% confidence interval (CI) 1.12-2.32, P = 0.010] when adjusted for gender and sample origin. The trait age of onset < 20 years was also associated with rs2048894 (OR 1.69, 95% CI 1.13-2.54, P = 0.011) in the pooled sample. To confirm this finding studies on even larger samples are required.
Backward Unlinkability for a VLR Group Signature Scheme with Efficient Revocation Check. (2011)

Abstract. Verifier-Local Revocation (VLR) group signatures, introduced by Boneh and Shacham in 2004, are a particular case of dynamic group signature schemes where the revocation process does not influence the activity of the signers. The verifiers use a Revocation List to check if the signers are revoked. In all known schemes, checking a signature requires a computational time linear in the number of revoked members. Usually, it requires one pairing per revoked user. Recently, Chen and Li proposed a scheme where Revocation Check uses exponentiations instead of pairings. In this paper, we first propose a correction of their scheme to enable a full proof of the traceability property. Then our main contribution is to extend this tweaked scheme to ensure Backward Unlinkability. This important property prevents the loss of anonymity of past signatures when a user is revoked. We succeed in achieving this consequent improvement with a constant additional cost only. We thus obtain the scheme with the most efficient Revocation Check among VLR schemes enabling Backward Unlinkability.
Adrenal Cortical Adenoma (2013)

The Carney triad is the combination of gastric stromal sarcoma, pulmonary chondroma, and extra-adrenal paraganglioma. Herein, we describe the clinical, imaging, pathologic, and follow-up findings from 14 patients for a fourth component of the syndrome, adrenal adenoma. The adrenal neoplasm was asymptomatic and usually a late finding. Results of adrenocortical function tests were normal. Computed tomography revealed low-density adrenal masses that were consistent with adenomas. Bilateral lesions were present in 4 patients. In 13 of the 14 patients who underwent surgery, resected adrenal glands and biopsy specimens featured 1 or more circumscribed, yellow tumors, up to 3.5 cm in diameter, composed of well-differentiated polygonal cells with clear vacuolated cytoplasm and a smaller component of eosinophilic cells. The extratumoral cortex had combinations of normal histologic features, discrete clear cell micronodules, zonal clear cell hypertrophy, and marked atrophy. The lesion in the 14th patient was different, grossly and microscopically resembling the usual sporadic cortisol-secreting adenoma. After the tumor was excised, the patient required glucocorticoid support. None of the tumors recurred or metastasized. Fourteen additional patients had unilateral or bilateral adrenal tumors consistent with adenomas detected by imaging studies.
Abstract LB-017: Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to marked dependence on PRMT5 (2016)

Abstract Metabolic genes are increasingly recognized as targets of somatic genetic alteration in human cancer often leading to profound changes in intracellular metabolite concentrations. 5-Methylthioadenosine Phosphorylase (MTAP) is a key enzyme in the methionine salvage pathway that metabolizes methylthioadenosine (MTA) to adenine and methionine. Its chromosomal position proximal to CDKN2A results in frequent collateral homozygous deletion in a wide range of human cancers. By interrogating data from a large scale deep-coverage pooled shRNA screen across 390 cancer cell line models we found that the viability of MTAP null cancer cells is strongly impaired upon shRNA-mediated depletion of the protein arginine methyltransferase PRMT5. In MTAP deleted cells there is marked accumulation of the substrate MTA and surprisingly, we find that MTA is a specific inhibitor of the catalytic activity of PRMT5. In keeping with these data, knockout of MTAP in an MTAP-proficient cell line led to increased MTA levels and rendered them sensitive to PRMT5 depletion. Moreover, reconstitution of MTAP in an MTAP-deficient cell line fully rescued PRMT5 dependence. Collectively, these findings indicate that the collateral loss of MTAP in CDNK2A deleted cancers leads to accumulation of MTA that thereby creates a hypomorphic PRMT5 state that is selectively sensitized towards further PRMT5 inhibition. Citation Format: Konstantinos Mavrakis, E Robert McDonald III, Michael R. Schlabach, Eric Billy, Gregory R. Hoffman, Antoine deWeck, David A. Ruddy, Kavitha Venkatesan, Greg McAllister, Rosalie deBeaumont, Samuel Ho, Yue Liu, Yan Yan-Neale, Guizhi Yang, Fallon Lin, Hong Yin, Hui Gao, David Randal Kipp, Songping Zhao, Joshua T. McNamara, Elizabeth R. Sprague, Young Shin Cho, Justin Gu, Ken Crawford, Vladimir Capka, Kristen Hurov, Jeffrey A. Porter, John Tallarico, Craig Mickanin, Emma Lees, Raymond Pagliarini, Nicholas Keen, Tobias Schmelzle, Francesco Hofmann, Frank Stegmeier, William R. Sellers. Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to marked dependence on PRMT5. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr LB-017.
Charging Strategies and Implications for Corporate Electric Vehicle Fleets (2018)

Employees are increasingly using electric vehicles (EVs) as their choice of company car. This means modern companies are becoming owners of EV fleets that need to charge on company premises. Without an effective charging strategy the cost of running an EV charging infrastructure for a large fleet of company EVs quickly becomes prohibitive. For this purpose, we investigate three different charging strategies: (i) a “naive” baseline strategy, (ii) intelligent charging (using an optimal schedule) and (iii) multi-location intelligent charging (i.e. allowing charging at home). Experimental results from simulations show how the selection of a charging strategy affects the number of adequately charged EVs as well as infrastructure utilization. Multi-location intelligent charging is the most effective strategy.
Roles of vasoconstrictor prostaglandins, COX-1 and -2, and AT1, AT2, and TP receptors in a rat model of early 2K,1C hypertension (2007)

Angiotensin (ANG) II activating type 1 receptors (AT(1)Rs) enhances superoxide anion (O(2)*(-)) and arachidonate (AA) formation. AA is metabolized by cyclooxygenases (COXs) to PGH(2), which is metabolized by thromboxane (Tx)A(2) synthase to TxA(2) or oxidized to 8-isoprostane PGF(2alpha) (8-Iso) by O(2)*(-). PGH(2), TxA(2), and 8-Iso activate thromboxane-prostanoid receptors (TPRs). We investigated whether blood pressure in a rat model of early (3 wk) two-kidney, one-clip (2K,1C) Goldblatt hypertension is maintained by AT(1)Rs or AT(2)Rs, driving COX-1 or -2-dependent products that activate TPRs. Compared with sham-operated rats, 2K,1C Goldblatt rats had increased mean arterial pressure (MAP; 120 +/- 4 vs. 155 +/- 3 mmHg; P < 0.001), plasma renin activity (PRA; 22 +/- 7 vs. 48 +/- 5 ng x ml(-1) x h(-1); P < 0.01), plasma malondialdehyde (1.07 +/- 0.05 vs. 1.58 +/- 0.16 nmol/l; P < 0.01), and TxB(2) excretion (26 +/- 4 vs. 51 +/- 7 ng/24 h; P < 0.01). Acute graded intravenous doses of benazeprilat (angiotensin-converting enzyme inhibitor) reduced MAP at 20 min (-36 +/- 5 mmHg; P < 0.001) and excretion of TxA(2) metabolites. Indomethacin (nonselective COX antagonist) or SC-560 (COX-1 antagonist) reduced MAP at 20 min (-25 +/- 5 and -28 +/- 7 mmHg; P < 0.001), whereas valdecoxib (COX-2 antagonist) was ineffective (-9 +/- 5 mmHg; not significant). Losartan (AT(1)R antagonist) or SQ-29548 (TPR antagonist) reduced MAP at 150 min (-24 +/- 6 and -22 +/- 3 mmHg; P < 0.001), whereas PD-123319 (AT(2)R antagonist) was ineffective. Acute blockade of TPRs, COX-1, or COX-2 did not change PRA, but TxB(2) generation by the clipped kidney was reduced by blockade of COX-1 and increased by blockade of COX-2. 2K,1C hypertension in rats activates renin, O(2)*(-), and vasoconstrictor PGs. Hypertension is maintained by AT(1)Rs and by COX-1, but not COX-2, products that activate TPRs.
Parallelizing post-placement timing optimization (2006)

This paper presents an efficient modeling scheme and a partitioning heuristic for parallelizing VLSI post-placement timing optimization. Encoding the paths with timing violations into a task graph, our novel modeling scheme provides an efficient representation of the timing and spatial relations among timing optimization tasks. Our new partitioning algorithm then assigns the task graph into multiple sessions of parallel processes, so that interprocessor communication is completely eliminated during each session. This partitioning scheme is especially useful for parallelizing processes with heavily connected tasks and, therefore, high communication requirements. For circuits with 20-130 thousand cells, the partitioning heuristic achieves speedups in excess of 5/spl times/ without degrading solution quality by dynamically utilizing 1-8 processors.