gebhart/patrepeval huggingface dataset:
Production performance of Niobrara and Codell: Integrating compositional modeling with 4D seismic (2017)

We developed a compositional model to evaluate the primary production and future performance of Niobrara and Codell in the Wattenberg field. Compositional modeling involves tracking (1) the whereabouts of the molecular components in the reservoir to determine their effect on production and (2) the three-phase flow of water, oil and gas in the reservoir. To build the model, an integrated workflow was developed, with input information from geology, geophysics, petrophysics, completion and production data. The simulation model was validated by history matching two and a half years of reservoir performance and rate-transient analyses. The model was further tuned by integrating with the observed reservoir seismic response. Finally, the ethane-based gas injection enhanced oil recovery (EOR) was evaluated as a potential process to increase oil recovery in the field. Presentation Date: Thursday, September 28, 2017 Start Time: 10:10 AM Location: 351F Presentation Type: ORAL
ISO/MPEG-H 3D Audio: SAOC 3D Decoding and Rendering (2015)

S.677-687
Distributed dielectric charging and its impact on RF MEMS devices (2004)

This paper gives a new insight into the problem of RF MEMS irreversible stiction due to dielectric charging. Previous reported works describing the phenomenon only account for a drift of the actuation characteristics as a whole as they consider uniform charge densities. We demonstrate how the spatial charge distribution in the dielectric layer can result in the failure of the devices. We emphasize the role of the variance of the distribution, a parameter neglected in the literature. Our model can account for a shift of the C-V actuation characteristics but also for a change in its profile. In particular, the pull-out window can be narrowed and even made to disappear as a result of the non-zero variance of the charge distribution. We identify the processing, the contact conditions and the distributed charge depths as variance- and thus failure-enhancer parameters.
Submicrometer lithography using lensless high-efficiency holographic systems (1990)

A hologram recording geometry that was total internal reflection of the reference and reconstruction beams from a photosensitive material surface is used to achieve 0.5-microm resolution at lambda = 457 nm in the readout of a reconstructed image on a photoresist. Such a geometry has demonstrated stable image quality for parallel displacement within the illuminated area and diffraction efficiency tolerance within a +/-2 degrees tilt about the axis of the reconstruction beam. The total-internal-reflection recording system provides double-fringe sets for each plane component inside the volume hologram; therefore, a diffraction efficiency as high as 80% was observed. The result is applicable to highvolume submicrometer lithography and can be expanded to a 20-cm (8-in.) semiconductor submicrometer pattern. The use of a large-aperture, well-collimated laser beam provides us with much higher throughput than that of existing lithography machines.
Correction: Imaging Trans-Cellular Neurexin-Neuroligin Interactions by Enzymatic Probe Ligation (2013)

Neurexin and neuroligin are transmembrane adhesion proteins that play an important role in organizing the neuronal synaptic cleft. Our lab previously reported a method for imaging the trans-synaptic binding of neurexin and neuroligin called BLINC (Biotin Labeling of INtercellular Contacts). In BLINC, biotin ligase (BirA) is fused to one protein while its 15-amino acid acceptor peptide substrate (AP) is fused to the binding partner. When the two fusion proteins interact across cellular junctions, BirA catalyzes the site-specific biotinylation of AP, which can be read out by staining with streptavidin-fluorophore conjugates.
Baseline and post-treatment circulating tumor cell (CTC) counts with prostate-specific membrane antigen (PSMA)-targeted radionuclide therapy (TRT) in men with metastatic castration-resistant prostate cancer (mCRPC). (2021)

158 Background: CTC counts are an independent prognostic factor in men with mCRPC; certain changes following treatment (conversion from detectable to undetectable or unfavorable to favorable) are associated with improved overall survival. Most PSMA-TRT efficacy data have focused on PSA or imaging changes. Here, we describe baseline and post-treatment CTC counts from subjects receiving PSMA-TRT. Methods: Men with mCRPC treated on prospective clinical trials of PSMA-TRT and with available CTC counts (CellSearch) were included in our analysis. Depending upon the era of the trial, post-treatment counts were performed at 4-6 (initial era) or 12 weeks (recent era) after a single cycle of PSMA-TRT (individual trial data reported elsewhere). We describe CTC counts at baseline and compare pre-treatment counts to those after PSMA-TRT. Results: 116 men treated with PSMA-TRT had baseline CTC count (90 with both pre- and post-treatment CTC). Forty-four patients (37.9%) received 177Lu-J951, 46 (39.7%) received 177Lu-PSMA-617, and 26 (22.4%) received 225Ac-J591. Median age was 71.5. Fifty-eight patients (50%) had previously received taxane chemotherapy, median PSA was 82.98 ng/mL, and 66 (56.9%) were in the high-risk Halabi (CALGB) prognostic group. Eighty-nine out of one hundred sixteen (76.7%) had detectable baseline CTC and 58/116 (50%) had unfavorable baseline CTC count. Forty-nine out of seventy (70%) had post-treatment CTC count decline, 23/70 (32.9%) converted from detectable to undetectable, and 17/47 (36.2%) converted from unfavorable to favorable. CTC changes stratified by type of PSMA-TRT are reported in the table. Conclusions: This is the largest analysis of CTC changes in patients who have received PSMA-TRT. In addition to PSA changes and other previously reported outcomes, even when low doses of radionuclide therapy as part of dose-escalation studies are included, the majority with detectable CTC counts have post-treatment CTC count decline. A significant portion of patients experience favorable CTC changes. [Table: see text]
An analytical model for the propagation of bending waves on a plant stem due to vibration of an attached insect (2016)

A mathematical model is presented to examine the propagation of bending waves on a plant stem that are induced by vibratory excitation from an attached insect. This idealized model represents the insect body as a mass and the legs as a linear spring along with a general time-varying force that is assumed to act in parallel with the spring. The spring connects the mass to a stem modeled as a beam having uniform geometric and material properties. The linearly elastic beam is assumed to undergo pure vibratory bending and to be infinitely long in each direction. The equations that govern the insect-induced, coupled motions of both the beam and the mass are solved for arbitrary time varying forces produced by the insect's legs. Solutions for the frequency response indicate that the response is dominated by frequency components near the natural resonant frequency of the attached insect while at higher frequencies the amplitude of the response is strongly influenced only by the properties of the stem.
Chemistry of acetylene exposed to alumina and alumina-supported rhodium catalysts (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of acetylene exposed to alumina and alumina-supported rhodium catalystsD. M. Hanson, Y. Udagawa, and K. TohjiCite this: J. Am. Chem. Soc. 1986, 108, 14, 3884–3888Publication Date (Print):July 1, 1986Publication History Published online1 May 2002Published inissue 1 July 1986https://pubs.acs.org/doi/10.1021/ja00274a004https://doi.org/10.1021/ja00274a004research-articleACS PublicationsRequest reuse permissionsArticle Views86Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy (2021)

Hypoxia is a key factor responsible for the failure of therapeutic response in most solid tumors and promotes the acquisition of tumor resistance to various antitumor immune effectors. Reshaping the hypoxic immune suppressive tumor microenvironment to improve cancer immunotherapy is still a relevant challenge. We investigated the impact of inhibiting HIF-1α transcriptional activity on cytotoxic immune cell infiltration into B16-F10 melanoma. We showed that tumors expressing a deleted form of HIF-1α displayed increased levels of NK and CD8<sup>+</sup> effector T cells in the tumor microenvironment, which was associated with high levels of CCL2 and CCL5 chemokines. We showed that combining acriflavine, reported as a pharmacological agent preventing HIF-1α/HIF-1β dimerization, dramatically improved the benefit of cancer immunotherapy based on TRP-2 peptide vaccination and anti-PD-1 blocking antibody. In melanoma patients, we revealed that tumors exhibiting high CCL5 are less hypoxic, and displayed high NK, CD3<sup>+</sup>, CD4<sup>+</sup> and CD8<sup>+</sup> T cell markers than those having low CCL5. In addition, melanoma patients with high CCL5 in their tumors survive better than those having low CCL5. This study provides the pre-clinical proof of concept for a novel triple combination strategy including blocking HIF-1α transcription activity along vaccination and PD-1 blocking immunotherapy.
Abstract 3603: Development of novel small molecule PIM kinase inhibitors (2011)

Abstract The PIM family of serine/threonine kinases, regulated by cytokines and growth factors, is over-expressed in multiple cancer types, including prostate tumors and hematologic malignancies. Recent reports of PIM kinase inhibitors have been implicated with anti-tumor growth activity in cancer cells and xenograft models, thus providing evidence that PIM kinases are attractive targets for anticancer drug development. Jasco Pharmaceuticals has developed a proprietary focused screening library of small molecules designed to inhibit PIM kinase activity. Kinase panel screening of the focused set identified nanomolar inhibitors from a novel chemical series. To further characterize the compounds, Jasco Pharma has established a research partnership with Crown BioScience for access to its cancer cell line and human primary tumor (HuPrime) xenograft models. The initial efforts of this partnership involved the identification of cancer cell lines which express high levels of PIM kinases for anti-proliferation studies and MOA exploration. Medicinal chemistry optimization provided a cluster of compounds with low single-digit micromolar anti-proliferation activity. These improved compounds have been demonstrated to act through a PIM driven mechanism of action, decreasing the levels of the proto-oncogene c-myc and the phosphorylation of the proteins BAD and 4E-BP1. In order to select the compounds with better in vivo drug activity, we performed in vivo PK followed by plasma protein binding assay (PPB) and drug-drug interaction (DDI) analysis instead of the whole series of in vitro ADME property assays. Four compounds were picked up for in vivo efficacy study according to their potency, in vivo pk characteristics, results of PPB and DDI. Preliminary results indicated that one compound had significant anti-tumor activity in MV-4-11 tumor models. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3603. doi:10.1158/1538-7445.AM2011-3603
MU-MIMO and CSI Feedback Performance of NR/LTE (2019)

The Re1-15 physical layer air-interface specifications for NR (5G) and LTE (4G) has been released by 3GPP in September 2018. This paper aims to study two principal gain mechanisms introduced in NR (compared to LTE) targeting spectral efficiency improvements -(i) high order MU-MIMO with up to 12 layer spatially multiplexed transmission and (ii) higher resolution of CSI feedback with Type II feedback mechanism. In order to perform a fair comparison between LTE and NR, we maintain the same overhead, sub-carrier spacing and antenna configurations among other parameters. Although it is known that NR can provide benefits over LTE in terms of deployment flexibility, spectral efficiency and latency using mechanisms like multiple numerology support, lower control channel and reference signal overhead or lower guard bands we believe that the gain mechanisms (i) and (ii) are fundamental and a quantification of this aspect is attractive to operators and vendors who may consider NR or LTE deployments in sub-6 GHz bands.
Gene transfer into skeletal muscle using novel AAV serotypes (2004)

These results show that AAV2/7 and AAV2/8 are able to transduce muscle fibers of immunocompetent mice very efficiently, offering new perspectives in gene transfer of skeletal muscle.
Randomized controlled trial comparing submucosal endoscopy with mucosal resection and endoscopic submucosal dissection in the esophagus and stomach: Animal study (2017)

SEMR and traditional ESD are comparable techniques in safety and effectiveness when carried out in the esophagus and stomach. SEMR may serve as a more appealing technical option for endoscopists who are unable to sustain a traditional ESD practice volume.
Bulk Network Data Collection System (2013)

Collecting large amounts of data from network infrastructure devices
has never been very easy. Existing methods generate CPU and memory
loads that may be unacceptable, the output varies across
implementations and can be difficult to parse, and these methods are
often difficult to scale. I2RS programmatic interfacing with the
routing system may exacerbate this problem: state needs to be
collected from nodes and fed to consumers participating in the control
plane that may not be physically close to the nodes. This state
includes not only control plane information, but elements of the data
plane that have a direct impact on control plane behavior, like
traffic engineering. This document outlines a set of use cases
requiring a flexible framework to collect routing system data, and the
features and functionality needed to make such a framework useful for
these use cases.
Influence of sex hormones on coxsackie virus group B, type 3 induced myocarditis in Balb/c mice (1987)

Susceptibility to coxsackie virus group B, type 3 (CVB3) induced myocarditis changes with age. Very young (< 4 weeks) Balb/c mice show minimal cardiac injury after infection, while young adult males (6–12 weeks) develop severe myocarditis. Age-matched females remain largely protected. As the mice continue to age, susceptibility in females gradually increases while that in males decreases, ultimately resulting in equal myocardial damage between the sexes by 40 weeks of age. Enhanced myocarditis in old females correlates withincreased humoral and cellular immunity to the virus and heart antigens and results from decreased oestrogen levels in these animals.
Multicasting in UMTS (2002)

Future third generation wireless network operators, such as those holding UMTS (Universal Mobile Telecommunications System) licenses will be able to deliver higher bandwidth content rich services over new infrastructure to end-users of innovative new terminal equipment. In order to reduce the risk of potential network overload, it is envisaged that in future, multimedia of mass interest will be multicast simultaneously to multiple users in the network. Applications such as those becoming more widely deployed on the Internet, (video/audio streaming) will provide the revenue pull to compel UMTS operators to consider re-using them in their networks. The Internet Engineering Task Force, (IETF) has accounted for these traffic requirements by introducing optional protocols that would avoid the replication of packets so that applications could be transported in a more cost effective way, (IP Multicast). In order to allow similar one-to-many services to be used in UMTS, the Third Generation Partnership Project, (3GPP) has begun optimising the future global standards for UMTS. In future UMTS networks, high bit rate services could be transported over bearers in a more resource efficient manner, (broadcast/multicast applications) addressing the issues that are unique to wide area wireless environment. This paper provides an overview of the potential architectural design challenges that would allow more efficient distribution of unidirectional point-to-multipoint multimedia to multiple subscribers, whilst conserving network resources both in the core-network and the radio access network.
Enhancing Traditional Process SCADA and Historians for Industrial and Commercial Power Systems With Energy (Via IEC 61850) (2015)

The coordination of large-scale distributed measurement and control systems, such as supervisory control and data acquisition (SCADA) and other process control system implementations, require reliable and robust networks that can connect thousands of remote devices from multiple remote locations. Additionally, many heavy industries have ever-increasing demands for their infrastructure to handle more network services and deliver a full spectrum of the control and monitoring of thousands and even tens of thousands of points within their global business operations. This paper will outline a novel method of providing a convergent use of the International Electrotechnical Commission 61850 protocol within process control networks to provide a more deterministic type of process control, monitoring, and energy management. The benefits of the real-time archiving of process values, process messages, the intelligent electronic device status, and alarm data, along with process batch data, can be achieved in an advancement of traditional historian-based systems. This new approach provides traditional downtime reports and alarm summaries for maintenance purposes and the added benefits of providing the opportunity for highly accurate and time-synchronized energy consumption and energy balance data, along with efficiency reports of various production or process operations.
Degradation Mechanisms of Supported Pt Nanocatalysts in Proton Exchange Membrane Fuel Cells: An Operando Study through Liquid Cell Transmission Electron Microscopy (2020)

Nanocatalysts’ degradation is a limiting factor for the development of polymer electrolyte membrane for fuel cells (PEMFCs). In this work, a dedicated sample holder has been used to mimic the cathode of a PEMFC at the earliest stages of the aging process, i.e., under accelerated stress test after up to 500 cycles. The mechanisms of surface area loss of supported platinum nanoparticles (Pt NPs) have been monitored in real-time and operando conditions by coupling liquid cell transmission electron microscopy (LTEM) to energy-filtered transmission electron microscopy (EFTEM), while cyclic voltammograms (CVs) were simultaneously recorded. The study has been performed using an ink made of a commercial catalyst (Tanaka-TEC10V50E) containing Pt NPs intended for automotive applications (3.0 ± 0.4 nm). First, a protocol has been set up to mitigate the electron-beam-induced radiolysis effects to a level that related artifacts are hindered or at least not appreciably detected during the duration of the experiment. At the same time, the resolution limit of the microscope has been pushed below 1 nm. Afterward, several degradation pathways were first identified and categorized and then correlated to the evolution of both the electrochemical active surface area (ECSA) and the Pt oxide reduction peak. We analyze reported evidence that the electrochemical aging favors the dissolution of the smaller Pt NPs. Dissolved cations are then observed to redispose onto larger supported Pt particles (electrochemical Ostwald ripening) or to be transported within the electrolyte, being either the aqueous acidic solution or the ionomer where they can precipitate (dissolution/precipitation process).
An evaluation framework for 360-degree video compression (2017)

360-degree video is emerging as a new way of offering immersive visual experience. 360-degree video can be viewed on dedicated head mounted devices as well as on conventional 2D displays. Due to increased resolution to support wide field of view, efficient compression of 360-degree video becomes crucial. Whereas it is of significant interest to evaluate how different projection formats impact the compression efficiency of 360-degree video, a main technical challenge is that the input video is captured in a given native projection format, and that the native format has an obvious edge over other projection formats. In this paper, an evaluation framework is proposed to reduce the bias towards the native projection format when comparing different projection formats and their impact on 360-degree video compression. Additionally, a quality metric called area weighted spherical PSNR (AW-SPSNR) is proposed for objective 360-degree video quality evaluation. The proposed evaluation framework was included in the common test conditions defined for the exploration work of 360-degree video compression technologies under the Joint Video Exploration Team (JVET).
Maternal and female fetal testosterone levels are associated with maternal age and gestational weight gain (2017)

Young maternal age and excessive maternal weight gain may increase the prenatal androgen exposure of female fetuses. Further studies are needed to explore this finding.
LONGITUDINAL MONITORING OF CYCLOSPORINE USING A RADIOIMMUNOASSAY SPECIFIC FOR THE PARENT DRUG (1989)

Copeland, Kenneth R.; Yatscoff, Randall W.; Jeffery, John; Rush, David Author Information
MiR-29 MicroRNAs Regulate IGF-1R Expression and Contribute Mantle Cell Lymphoma Growth and Survival. (2009)

Abstract Abstract 1957 Poster Board I-980 Mantle cell lymphoma (MCL) is now recognized as a distinct clinicopathologic subtype of B-cell lymphomas and carries the poorest prognosis among NHL subtypes with a median survival is 3 to 4 years. Clearly better understanding of MCL oncogenesis and novel therapeutic approaches to treating MCL are needed. Mounting evidence now shows that small noncoding microRNAs (miRNAs) can play roles as oncogenes or tumor suppressor genes, suggesting their contribution to cancer development and progression. Here, we for the first time, demonstrated that that miR-29a-c is frequently deleted or down-regulated and IGF-1R is often over-expressed in primary mantle cell lymphoma cells. Expression of miR-29 inversely correlates with the expression of IGF-1R. Consistent with these results, 1) overexpression of miR-29-c down-regulated IGF-R1, 2) overexpression of miR-29c inhibited cell growth, colony formation and induced cell cycle arrest in MCL cells, 3) depletion of miR-29-c by anti-miR29-c increased the threshold for apoptosis, 4) enforced expression of miR-29c suppressed MCL growth and tumor progression in NOD/SCID mouse xenograft models, 5) miR-29 directly regulates IGF-1R expression . Furthermore cell cycle arrest induced by these miRNAs depends on the expression of IGF-1R. Our results indicate that miR-29a-c are implicated in MCL cell cycle control, survival and likely contribute to the tumorigenesis of MCL. Disclosures: No relevant conflicts of interest to declare.