gebhart/patrepeval huggingface dataset:
Critical Role for the α-1B Adrenergic Receptor at the Sympathetic Neuroeffector Junction (2004)

The alpha-1 adrenergic receptors (alpha(1)ARs) are critical in sympathetically mediated vasoconstriction. The specific role of each alpha(1)AR subtype in regulating vasoconstriction remains highly controversial. Limited pharmacological studies suggest that differential alpha(1)AR responses may be the result of differential activation of junctional versus extrajunctional receptors. We tested the hypothesis that the alpha(1B)AR subtype is critical in mediating sympathetic junctional neurotransmission. We measured in vivo integrated cardiovascular responses to a hypotensive stimulus (induced via transient bilateral carotid occlusion [TBCO]) in alpha(1B)AR knockout (KO) mice and their wild-type (WT) littermates. In WT mice, after dissection of the carotid arteries and denervation of aortic baroreceptor buffering nerves, TBCO produced significant pressor and positive inotropic effects. Both responses were markedly attenuated in alpha(1B)AR KO mice (change systolic blood pressure 46+/-8 versus 11+/-2 mm Hg; percentage change in the end-systolic pressure-volume relationship [ESPVR] 36+/-7% versus 12+/-2%; WT versus KO; P<0.003). In vitro alpha(1)AR mesenteric microvascular contractile responses to endogenous norepinephrine (NE; elicited by electrical field stimulation 10 Hz) was markedly depressed in alpha(1B)AR KO mice compared with WT (12.4+/-1.7% versus 21.5+/-1.2%; P<0.001). In contrast, responses to exogenous NE were similar in alpha(1B)AR KO and WT mice (22.4+/-7.3% versus 33.4+/-4.3%; NS). Collectively, these results demonstrate a critical role for the alpha(1B)AR in baroreceptor-mediated adrenergic signaling at the vascular neuroeffector junction. Moreover, alpha(1B)ARs modulate inotropic responses to baroreceptor activation. The critical role for alpha(1B)AR in neuroeffector regulation of vascular tone and myocardial contractility has profound clinical implications for designing therapies for orthostatic intolerance.
Ultra-wideband communications: an idea whose time has come (2003)

Summary form only given. In February 2002, a law-and-order of the federal communications commission (FCC) gave the "green light" (spectral mask in the range 3.1-10.6 GHz) for commercial applications of ultra wideband (UWB) systems. Since this recent FCC release, UWB has emerged as an exciting technology whose "time has come" for wireless communications, and local area networking. Conveying information over ultra-short waveforms, UWB technology allows for very accurate delay estimates providing position and localization capabilities within a few centimeters. The scarcity of bandwidth resources coupled with the capability of IR to overlay existing systems, welcomes UWB connectivity in the workplace, and at home for indoor and especially short range wireless links. However, to realize these attractive features, UWB research and development has to cope with formidable challenges. This plenary will provide the fundamentals of UWB communication systems, driving applications, recent developments, and open problems.
What Gastroenterologists Should Know About the Gray Market, Herbal Remedies, and Compounded Pharmaceuticals and Their Regulation by the Food and Drug Administration (2013)

Ehrenpreis, Eli D. MD1; Kulkarni, Prasad MD2; Burke, Carol MD3 the FDA-Related Matters Committee of the American College of Gastroenterology Author Information
Threshold Switching in Amorphous Cr-Doped Vanadium Oxide for New Crossbar Selector (2016)

Symmetrical (Pt) electroded undoped (Pt/a-VO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> /Pt) and Cr-doped amorphous Vanadium Oxide (Pt/a-V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-y</sub> Cr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">y</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> /Pt) devices were fabricated and electrically analyzed. Both devices show reproducible and symmetrical threshold switching after an initial forming step. However, the kind of threshold switching was basically different. For the undoped VO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> , threshold switching was identified as a low T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">C</sub> , VO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> -type IMT, consistent with disappearance of the switching around 60 °C, whereas Cr-doped VO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> switches up to > 90 °C, with a lower OFF-state current. These properties together with the poor conduction in the initial amorphous films make this new Cr-doped amorphous VO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> material of high interest for selector material in both 2D 1S1R and a newly proposed 3D selector scheme.
ChemInform Abstract: Synthesis of an Esterase‐Sensitive Cyclic Prodrug of a Model Hexapeptide Having Enhanced Membrane Permeability and Enzymatic Stability Using an Acyloxyalkoxy Promoiety (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Neuronal Fractalkine Expression in HIV-1 Encephalitis: Roles for Macrophage Recruitment and Neuroprotection in the Central Nervous System (2000)

HIV-1 infection of the brain results in chronic inflammation, contributing to the neuropathogenesis of HIV-1 associated neurologic disease. HIV-1-infected mononuclear phagocytes (MP) present in inflammatory infiltrates produce neurotoxins that mediate inflammation, dysfunction, and neuronal apoptosis. Neurologic disease is correlated with the relative number of MP in and around inflammatory infiltrates and not viral burden. It is unclear whether these cells also play a neuroprotective role. We show that the chemokine, fractalkine (FKN), is markedly up-regulated in neurons and neuropil in brain tissue from pediatric patients with HIV-1 encephalitis (HIVE) compared with those without HIVE, or that were HIV-1 seronegative. FKN receptors are expressed on both neurons and microglia in patients with HIVE. These receptors are localized to cytoplasmic structures which are characterized by a vesicular appearance in neurons which may be in cell-to-cell contact with MPs. FKN colocalizes with glutamate in these neurons. Similar findings are observed in brain tissue from an adult patient with HIVE. FKN is able to potently induce the migration of primary human monocytes across an endothelial cell/primary human fetal astrocyte trans-well bilayer, and is neuroprotective to cultured neurons when coadministered with either the HIV-1 neurotoxin platelet activating factor (PAF) or the regulatory HIV-1 gene product Tat. Thus focal inflammation in brain tissue with HIVE may up-regulate neuronal FKN levels, which in turn may be a neuroimmune modulator recruiting peripheral macrophages into the brain, and in a paracrine fashion protecting glutamatergic neurons.
Fire Retardancy, Thermomechanical and Thermal Properties of PP/PC Blends (2005)

This work investigates the fire retardancy, the thermal and thermomechanical properties of PP/PC blends using commercially available grafted polyolefins with functional groups as compatibilizing agent. In the first part, the effect of compatibilizer on the morphology has been correlated with the thermomechanical properties. The blends, containing 75% of PP and 25% of PC or 22% PC plus 3% compatibilizer have been prepared during the melt processing in a mixer. The compatibilizers were grafted maleic anhydride polypropylene (PP‐g‐MA) and a terpolymer ethylene/acrylic ester/maleic anhydride (EBuAMA). The thermal stability was improved up to 400°C when using compatibilizer in comparison with PP/PC blend. The thermomechanical properties were improved for PP/PC/PP‐g‐MA blend. It was found that the addition of compatibilizer slightly decrease the particle size of the minor PC phase. The crystallization temperature of PP in PP/PC/PP‐g‐MA increases which may explained the improvement of the properties of the blend in comparison with PP/PC/EBuAMA. In a second part, fire retardant formulation are developed. The fire retardant properties of the blend are slowly affected by the presence of a compatibilizer.
Intravascular molecular‐structural imaging with a miniaturized integrated near‐infrared fluorescence and ultrasound catheter (2021)

Coronary artery disease (CAD) remains a leading cause of mortality and warrants new imaging approaches to better guide clinical care. We report on a miniaturized, hybrid intravascular catheter and imaging system for comprehensive coronary artery imaging in vivo. Our catheter exhibits a total diameter of 1.0 mm (3.0 French), equivalent to standalone clinical intravascular ultrasound (IVUS) catheters but enables simultaneous near-infrared fluorescence (NIRF) and IVUS molecular-structural imaging. We demonstrate NIRF-IVUS imaging in vitro in coronary stents using NIR fluorophores, and compare NIRF signal strengths for prism and ball lens sensor designs in both low and high scattering media. Next, in vivo intravascular imaging in pig coronary arteries demonstrates simultaneous, co-registered molecular-structural imaging of experimental CAD inflammation on IVUS and distance-corrected NIRF images. The obtained results suggest substantial potential for the NIRF-IVUS catheter to advance standalone IVUS, and enable comprehensive phenotyping of vascular disease to better assess and treat patients with CAD.
Time Scaling of the Rates of Produced Fluids in Laboratory Displacements (2001)

In this report, the use of an asymptotic method, based on the time scaling of the ratio of produced fluids, to infer the relative permeability exponent of the displaced phase near its residual saturation, for immiscible displacements in laboratory cores was proposed. Sufficiently large injection rates, the existence of a power law can be detected, and its exponent inferred, by plotting in an appropriate plot the ratio of the flow rates of the two fluids at the effluent for some time after breakthrough.
Influence of wall thickness on the creep rupture performance of polyethylene pipe (2007)

Abstract A thermal gradient is inherent to the solidification of extruded profiles such as pipes. Depending on the magnitude of the gradient, varying levels of residual stresses are frozen‐in during the pipe fabrication step. In this investigation, the residual stress state of a polyethylene (PE) pipe was altered by changing its wall thickness. Creep rupture testing of the subject pipes of varying wall thickness provided an insight on how residual stresses influences both ductile and brittle fracture processes. POLYM. ENG. SCI., 47:516–521, 2007. © 2007 Society of Plastics Engineers.
Toward Theoretical Guidance for Two Common Questions in Practical Cross-Validation based Hyperparameter Selection (2023)

We show, to our knowledge, the first theoretical treatments of two common questions in cross-validation based hyperparameter selection: (1) After selecting the best hyperparameter using a held-out set, we train the final model using {\em all} of the training data -- since this may or may not improve future generalization error, should one do this? (2) During optimization such as via SGD (stochastic gradient descent), we must set the optimization tolerance $ρ$ -- since it trades off predictive accuracy with computation cost, how should one set it? Toward these problems, we introduce the {\em hold-in risk} (the error due to not using the whole training data), and the {\em model class mis-specification risk} (the error due to having chosen the wrong model class) in a theoretical view which is simple, general, and suggests heuristics that can be used when faced with a dataset instance. In proof-of-concept studies in synthetic data where theoretical quantities can be controlled, we show that these heuristics can, respectively, (1) always perform at least as well as always performing retraining or never performing retraining, (2) either improve performance or reduce computational overhead by $2\times$ with no loss in predictive performance.
ChemInform Abstract: Improved Synthesis of β‐Mannopyranosides by Intramolecular Aglycon Delivery. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Greville G. Corbett, Norman M. Fraser & Scott McGlashan (eds.), Heads in grammatical theory. Cambridge: Cambridge University Press, 1992. Pp. ix + 340. (1994)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Cable-driven additive manufacturing system (2023)

A cable-driven additive manufacturing system includes an end effector configured for linear translation within a three-dimensional workspace, an aerial hoist suspending the end effector by at least one suspension cable, a plurality of base stations disposed below the aerial hoist, and control cables running from each of the base stations to the end effector.
Targeting DNGR‐1 (CLEC9A) with antibody/MUC1 peptide conjugates as a vaccine for carcinomas (2014)

DCs are the most potent APCs and are the focus of many immunotherapeutic approaches for the treatment of cancer, although most of these approaches require the ex vivo generation and pulsing of DCs. We have targeted a subset of DCs in vivo using an Ab to DNGR-1, a C-type lectin dedicated to the cross-presentation of Ag expressed by subsets of DCs. HLA-A2 epitopes from the tumour-associated Ag, MUC1, were coupled to the anti-DNGR-1 Ab, and their efficacy in generating a Th1-cell response and inhibiting tumour growth was evaluated in a clinically relevant double transgenic mouse model expressing human MUC1 and A2K/b. Using this strategy, we demonstrate that an effective immune response to MUC1 can be generated, which results in a significant delay in the growth of MUC1-expressing tumours in both prophylactic and therapeutic settings. In addition, we also show, using PBMCs isolated from healthy volunteer blood, that target an MUC1 HLA-A2 epitope to human DNGR-1 in vitro can induce an MUC1-specific CD8(+) -T-cell response, which confirms the relevance of our in vivo murine results in the human setting.
Pentalogy of Cantrell with Pentalogy of Fallot and Left Ventricular Diverticulum (2023)

Pentalogy of Cantrell is a congenital anomaly characterized by a combination of birth defects involving the sternum, diaphragm, pericardium, abdominal wall, and heart. Pentalogy of Cantrell is a rare anomaly with high mortality. This paper describes the treatment of a 9-month-old girl with pentalogy of Cantrell, pentalogy of Fallot, and left ventricular diverticulum. The patient is alive and well 13 years after surgery.
Visual analytics for inspecting the evolution of a graph over time: Pattern discovery in a communication network (2015)

We present two approaches developed to visually analyze and find patterns in a communication network. The work was done for the VAST 2015 Mini-Challenge 2 (MC2), featuring a dataset with records of timestamps as well as identification of sender and receiver of text messages. Further information included the location from which a message was sent in the fictional amusement park. In the first approach, we present the data preprocessing pipeline we used for a custom visualization. In the second approach, we present how we used available data preprocessing and visualization software to get a quick and clear overview of the problem, and how we used the generated findings to feed our custom visualizations.
Connecting Atomistic-to-Continuum Coupling and Domain Decomposition (2008)

Many atomistic/continuum coupling algorithms utilize an overlapping subdomain method, where boundary data for local solves in atomistic and discretized continuum subdomains is provided from local solves in neighboring subdomains. Such coupling algorithms are closely related to the classical alternating Schwarz domain decomposition method, although little to no convergence or error analysis exists for such methods in an atomistic/continuum framework. We consider a specific alternating Schwarz algorithm for coupling a nonlocal atomistic model with a local finite element model and carry out a convergence and error analysis along with supporting numerical experiments.
Vacuum Ultraviolet Excited State Dynamics of the Smallest Ketone: Acetone (2021)

We combined tunable vacuum-ultraviolet time-resolved photoelectron spectroscopy (VUV-TRPES) with high-level quantum dynamics simulations to disentangle multistate Rydberg-valence dynamics in acetone. A femtosecond 8.09 eV pump pulse was tuned to the sharp origin of the A<sub>1</sub>(n3d<sub><i>yz</i></sub>) band. The ensuing dynamics were tracked with a femtosecond 6.18 eV probe pulse, permitting TRPES of multiple excited Rydberg and valence states. Quantum dynamics simulations reveal coherent multistate Rydberg-valence dynamics, precluding simple kinetic modeling of the TRPES spectrum. Unambiguous assignment of all involved Rydberg states was enabled via the simulation of their photoelectron spectra. The A<sub>1</sub>(<i>ππ</i>*) state, although strongly participating, is likely undetectable with probe photon energies ≤8 eV and a key intermediate, the A<sub>2</sub>(nπ*) state, is detected here for the first time. Our dynamics modeling rationalizes the temporal behavior of all photoelectron transients, allowing us to propose a mechanism for VUV-excited dynamics in acetone which confers a key role to the A<sub>2</sub>(nπ*) state.
Broadband dispersive Ge/YbF3mirrors for mid-infrared spectral range (2019)

Broadband dispersive mirrors operating in the mid-infrared spectral range of 6.5-11.5 μm are developed for the first time, to the best of our knowledge. The mirrors comprise Ge and YbF<sub>3</sub> layers, which have not been used before for manufacturing of multilayer dispersive optics. The design and production processes are described; mechanical stresses of the coatings are estimated based on experimental data; and spectral and phase properties of the produced mirrors are measured. The mirrors compensate group delay dispersion of ultrashort laser pulses accumulated by propagation through 4 mm ZnSe windows and additional residual phase modulation of an ultrashort laser pulse.
A Fluid/Solid Model for Predicting Slender Body Deflection in a Moving Fluid (2003)

An analytical solution is presented for the steady-periodic shape variation of a thin elastic beam subject to fluid mechanic forces and driven by the motion imposed on its ends. The general solution is applicable to such problems as swim fins and aerodynamic flutter, with the proper choice of boundary conditions. The general results are exemplified here by using specific boundary conditions that mimic the motion of swim fins. The calculated instantaneous shape, position, slopes, and lateral velocities of the fin are compared with corresponding measurements taken from underwater video of fins worn by divers swimming at a controlled speed. The analysis revealed new swim technique parameters that characterize the heel slope and its phase with respect to the heel motion. The calculated power, thrust, and Froude efficiency are presented in terms of these parameters.
A GPS Synchronized, Long-Range Uplink-Only Radio Designed for IoT (2018)

Targeting IoT, we have developed an efficient radio system. The system uses GPS (Global Positioning System) for time and frequency calibration. The system uses a newly designed LDPC as error correction, an efficient π/2 shift BPSK modulation and linear chirp modulation for spectrum spreading. In this system, the transmission channel is estimated using evenly-distributed sync symbols and the channel deterioration is corrected. Together with these technologies, we have experimentally confirmed that the system exhibits -144 dBm of sensitivity. We also confirmed that it could achieve long-range communication in an urban environment. Another experiment shows that signals from a fast moving object can also be decoded.
Evaluating Applicator Designs for Heating Nanoparticle Flow Chemistries Using Single-Mode Microwave Energy (2014)

A single-mode microwave system can provide an electro-magnetic field with very sharp peaks and high power densities which can heat chemical process fluids rapidly on a much shorter time scale than by convective means. This type of microwave heating provides the opportunity to reduce thermal gradients within process fluids which are important, for example, in the control of reactive precipitation processes used to produce colloidal nanomaterials. Here, the effects of flow applicator design on the thermal gradients and energy efficiency of the microwave-assisted heating is considered as a function of flow rate. A heat efficiency model is developed to simulate the single-mode microwave heating of a continuous flow process fluid over a variety of flow rates and powers. To validate the model, an experimental setup is developed involving a three kW 2450 MHz microwave processing system. The system was used to heat salt water over a range of concentrations while temperature change across a microwave heating zone was measured using in-situ fiber optic probes. Experimental results were found to be in good agreement with the model yielding an average error for all cases of 4.8% and an average error for cases with salinity of 17.3%. The model is used to evaluate the effects of applicator design on thermal gradients and energy efficiency with changes in flow rate.