gebhart/patrepeval huggingface dataset:
Integrated Product and Process Design of Microwave Modules Using AI Planning and Integer Programming (2002)

This paper describes the process planning techniques we developed for use in an Integrated Product and Process Design (IPPD) tool for the design and manufacture of microwave transmit/receive modules. Given a collection of data about the design of a microwave module, the IPPD tool uses a combination of AI planning and optimization-based tradeoff analysis to produce a collection of alternative designs and alternative process plans that have Pareto optimal values for manufacturing and purchasing lead time, process yield, cost, and number of suppliers. The IPPD tool provides a GUI for generating and examining these alternatives in real time, to help users modify the design to improve its cost and productivity.
Continuous induction with lenalidomide/dexamethasone versus autologous stem cell transplantation in newly diagnosed multiple myeloma: a case for response-adapted approach (2022)

Although upfront autologous stem cell transplantation (ASCT) generally improves progression-free survival (PFS) in newly diagnosed multiple myeloma (NDMM), the overall survival (OS) benefit and optimal timing of ASCT are not well established. Patients with early response may be able to safely continue induction and avoid ASCT without compromised outcomes. We report an extended follow-up analysis of a phase 2 trial that randomized transplant-eligible patients with NDMM who responded to induction (50/65 patients) to continued induction or ASCT; median follow-up was 8.0 years. Patients had similar 8-year PFS (55% vs. 43%), 8-year OS (83% vs. 72%), and rates of at least very good partial response (72% vs. 84%) whether continuing induction of lenalidomide and dexamethasone (Ld arm) or receiving ASCT (Ld + ASCT arm) (<i>p</i> = 0.5). Notably, over 50% of patients receiving continuous Ld had PFS of 5-10 years. These results suggest the need for prospective trials incorporating response-adapted therapeutic approaches to NDMM.STATEMENT OF PRIOR PRESENTATIONPresented in abstract form (interim analysis) at the 56th annual meeting of the American Society of Hematology (San Francisco, CA, 6 December 2014) and at the 57th annual meeting of the American Society of Hematology (Orlando, FL, 3 December 2015).
A narrowband interference rejection technique for DS‐CDMA system (2003)

Abstract Due to congestion in wireless frequency use, it is difficult to assign an independent frequency bandwidth to broadband wireless communication systems based on the DS‐CDMA (Direct Sequence Code Division Multiple Access) system. Therefore, operation of the DS‐CDMA system on the existing narrowband wireless system is contemplated. However, the interference of the transmitted power of the existing narrowband wireless system on the DS‐CDMA system has not been studied. There is a possibility that significant narrowband interference on the DS‐CDMA system may occur. In this paper, a narrowband interference rejection system in DS‐CDMA is proposed. By making use of prior information on the carrier frequency of the narrowband interference, a narrowband interference rejection process with little computational overhead is realized. © 2003 Wiley Periodicals, Inc. Electron Comm Jpn Pt 1, 87(3): 74–86, 2004; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/ecja.10076
Neural network pruning for biomedical image segmentation (2021)

Instead of manual segmentation, Segmentation using Artificial Neural Networks is very useful in biomedical image analysis. However, deploying artificial neural networks requires large memory footprint and computational costs. In this work, we propose a pruning approach to alleviate these requirements for the U-Net, which is the most popular segmentation neural network for biomedical image. Our approach handles upsampling layers and skip connections, which are essential components in U-Net architecture. We show that our approach achieves 2x speedup, more than 7x size reduction with less than 2% loss in average intersection-over-union (IOU) on PhC- U373 and DIC-HeLa biomedical data set.
A Dual, Systematic Approach to Malaria Diagnostic Biomarker Discovery (2021)

Overall, our results pave the way for the development of next-generation malaria RDTs based on new antigens by identifying 2 lead candidates with favorable diagnostic features and partially de-risked product development prospects.
Connectivity analysis of wireless sensor networks deployments in smart cities (2015)

Recent advances in the field of intelligent transportation systems have focused on the use of wireless networks to link vehicles and road infrastructure. Applications that might result from such networks range from the adaptive management of traffic lights to the detection of traffic jams and accidents. Whatever the case may be, it seems important to explore the possibilities and limitations of such networks, which the literature often portrays in a somewhat idealistic way (e.g. no packet loss, fully connected sensors, etc.). In this paper, we study the deployment of wireless sensor networks at intersections in some of the world's major cities and characterize their topologies. Using a propagation model that corresponds to a 2.4GHz IEEE 802.15.4 network interface, we focus our study on the global connectivity of graphs resulting from different networks. By deploying this type of network over 52 city and region maps extracted from OpenStreetMap, we show that cities can reasonably be classified into three network structure categories of low connectivity (i.e. a high number of connected components) and that it should be feasible to improve the networks by adding sensors. All the tools and the complete dataset are freely available online.
HEFT: Homomorphically Encrypted Fusion of Biometric Templates (2022)

This paper proposes a non-interactive end-to-end solution for secure fusion and matching of biometric templates using fully homomorphic encryption (FHE). Given a pair of encrypted feature vectors, we perform the following ciphertext operations, i) feature concatenation, ii) fusion and dimensionality reduction through a learned linear projection, iii) scale normalization to unit ℓ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> -norm, and iv) match score computation. Our method, dubbed HEFT (Homomorphi-cally Encrypted Fusion of biometric Templates), is custom-designed to overcome the unique constraint imposed by FHE, namely the lack of support for non-arithmetic operations. From an inference perspective, we systematically explore different data packing schemes for computationally efficient linear projection and introduce a polynomial approximation for scale normalization. From a training perspective, we introduce an FHE-aware algorithm for learning the linear projection matrix to mitigate errors induced by approximate normalization. Experimental evaluation for template fusion and matching of face and voice biometrics shows that HEFT (i) improves biometric verification performance by 11.07% and 9.58% AUROC compared to the respective unibiometric representations while compressing the feature vectors by a factor of 16 (512D to 32D), and (ii) fuses a pair of encrypted feature vectors and computes its match score against a gallery of size 1024 in 884 ms. Code and data are available at https://github.com/humananalysis/encrypted-biometric-fusion
Empirical projection-based basis-component decomposition method (2009)

Advances in the development of semiconductor based, photon-counting x-ray detectors stimulate research in the domain of energy-resolving pre-clinical and clinical computed tomography (CT). For counting detectors acquiring x-ray attenuation in at least three different energy windows, an extended basis component decomposition can be performed in which in addition to the conventional approach of Alvarez and Macovski a third basis component is introduced, e.g., a gadolinium based CT contrast material. After the decomposition of the measured projection data into the basis component projections, conventional filtered-backprojection reconstruction is performed to obtain the basis-component images. In recent work, this basis component decomposition was obtained by maximizing the likelihood-function of the measurements. This procedure is time consuming and often unstable for excessively noisy data or low intrinsic energy resolution of the detector. Therefore, alternative procedures are of interest. Here, we introduce a generalization of the idea of empirical dual-energy processing published by Stenner et al. to multi-energy, photon-counting CT raw data. Instead of working in the image-domain, we use prior spectral knowledge about the acquisition system (tube spectra, bin sensitivities) to parameterize the line-integrals of the basis component decomposition directly in the projection domain. We compare this empirical approach with the maximum-likelihood (ML) approach considering image noise and image bias (artifacts) and see that only moderate noise increase is to be expected for small bias in the empirical approach. Given the drastic reduction of pre-processing time, the empirical approach is considered a viable alternative to the ML approach.
Ability to Achieve Mediolateral Gap Balance with Instrumented Navigated Total Knee Arthroplasty – A Review of the First 150 Cases (2022)

Appropriate management of the soft tissue envelope at the time of the surgery is critical to the long- term success of total knee arthroplasty (TKA). In this regard, this computer-assisted orthopedic surgery ( a force-controlled intraarticular distractor. The first 150 cases performed by 16 surgeons were reported without any exclusions, and for each of these cases, the final mediolateral (ML) laxity was compared to the predicted ML laxity. The average signed ML laxity was well aligned with a neutral differential throughout the full arc of motion and ranged from -0.05mm at 35° of flexion to 0.37mm at 85° of flexion. The signed ML laxity curves tend to be surgeon specific. The average unsigned ML laxity was linear throughout the full arc motion and ranged from 1.14mm at 85° of flexion to 1.27mm at 30° of flexion. the targeted ML gap balance when using a featuring Despite data from all the users (not only design surgeons) involved with this pilot release were considered and the learning curve cases were not excluded, it was observed a high ability study evaluated the ability to achieve CAOS) system to achieve the targeted ML laxity using the proposed method.
Tunneling magnetoresistance oscillations due to charging effects in MgO double barrier magnetic tunnel junctions (2012)

We observe single-electron tunneling effect and tunneling magnetoresistance (TMR) oscillations in MgO double barrier magnetic tunnel junctions patterned with electron beam lithography and argon ion milling. The TMR oscillations are induced by the interplay of single charge effect and spin-dependent tunneling. The oscillations and its period can be well-controlled by properly engineering the thickness of MgO tunnel barriers and the size of the tunnel junctions.
Adaptive position detection of optical vortex using a Shack-Hartmann wavefront sensor (2015)

The low intensity regions existed around the singular point of optical vortex (OV) beams influence the position detection accuracy of phase singular points, especially for OVs of large topological charge. A new method using Shack-Hartmann wavefront sensor (SH-WFS) is proposed to solve this problem. In the method, we combine several phase slopes obtained at individual lenses of a lens array into one to avoid the influence of the low intensity region and use correlation matching with pre-calculated simulation data to get the accurate singular point position. The experimental results show that the position detection precision of this method is maintained less than 0.2 in unit of lens-size for OVs of charges -20 to 20.
Placental Alkaline Phosphatase (PLAP) Luminescent HTS assay - Probe 1 (2010)

Placental alkaline phosphatase (PLAP) is highly expressed in primate placental tissue. Its biological function and relevance are still unknown, but PLAP-like enzymes are detected in serum of patients with primary testicular tumors, in particular seminoma and other cancers. Consequently, the identification of PLAP-specific inhibitors with selectivity over tissue non-specific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP) may provide the necessary tools to characterize its biological role. Currently, inhibitors of PLAP lack either potency or selectivity. The small molecule probe ML085 (CID-25067483) is a biochemical inhibitor of PLAP, and will be useful to elucidate the key biological functions and natural substrates of human PLAP.
On oblique liquid curtains (2019)

In a recent paper ( J. Fluid Mech. , vol. 861, 2019, pp. 328–348), Benilov derived equations governing a laminar liquid sheet (a curtain) that emanates from a slot whose centreline is inclined to the vertical. The equations are valid for slender sheets whose characteristic length scale in the direction of flow is much larger than its cross-sectional thickness. For a liquid that leaves a slot with average speed, $u_{0}$ , volumetric flow rate per unit width, $q$ , surface tension, $\unicode[STIX]{x1D70E}$ , and density, $\unicode[STIX]{x1D70C}$ , Benilov obtains parametric equations that predict steady-state curtain shapes that bend upwards against gravity provided $\unicode[STIX]{x1D70C}qu_{0}/2\unicode[STIX]{x1D70E}&lt;1$ . Benilov’s parametric equations are shown to be identical to those derived by Finnicum, Weinstein, and Ruschak ( J. Fluid Mech. , vol. 255, 1993, pp. 647–665). In the latter form, it is straightforward to deduce an alternative solution of Benilov’s equations where a curtain falls vertically regardless of the slot’s orientation. This solution is consistent with prior experimental and theoretical results that show that a liquid curtain can emerge from a slot at an angle different from that of the slot centreline.
Cooperative nanomaterial system to sensitize, target, and treat tumors (2009)

A significant barrier to the clinical translation of systemically administered therapeutic nanoparticles is their tendency to be removed from circulation by the mononuclear phagocyte system. The addition of a targeting ligand that selectively interacts with cancer cells can improve the therapeutic efficacy of nanomaterials, although these systems have met with only limited success. Here, we present a cooperative nanosystem consisting of two discrete nanomaterials. The first component is gold nanorod (NR) "activators" that populate the porous tumor vessels and act as photothermal antennas to specify tumor heating via remote near-infrared laser irradiation. We find that local tumor heating accelerates the recruitment of the second component: a targeted nanoparticle consisting of either magnetic nanoworms (NW) or doxorubicin-loaded liposomes (LP). The targeting species employed in this work is a cyclic nine-amino acid peptide LyP-1 (Cys-Gly-Asn-Lys-Arg-Thr-Arg-Gly-Cys) that binds to the stress-related protein, p32, which we find to be upregulated on the surface of tumor-associated cells upon thermal treatment. Mice containing xenografted MDA-MB-435 tumors that are treated with the combined NR/LyP-1LP therapeutic system display significant reductions in tumor volume compared with individual nanoparticles or untargeted cooperative system.
Ultrathin glass wafer lamination and laser debonding to enable glass interposer fabrication (2015)

Interposer fabrication processes are applied in three-dimensional (3-D) integrated circuit (IC) integration to shorten the interconnection among different stacked chips and substrates. Because Si is a common material in semiconductor technology, Si interposers have been widely studied in many research activities. Compared with a Si wafer, glass substrates have the advantages of high resistivity, low dielectric constant, low insertion loss, adjustable coefficient of thermal expansion (CTE), and the possibility to use panel-size substrates as well as thin glass substrates (100 μm) to avoid the costly thinning process for realization of low-cost 2.5-D ICs. Thus, glass interposer fabrication is studied thoroughly in this paper. Thin glass wafers have reduced mechanical stiffness. Therefore, handling and shipping thin glass wafers (≤100 μm) throughout the semiconductor fabrication and packaging assembly processes are critical. Temporary wafer bonding technology is used in this study to bond a thin glass wafer to a carrier to improve the rigidity. Vacuum lamination technology is used in this study as a bonding process to enhance the costeffectiveness. After processing, the carrier is removed by laser debonding. The thin glass wafer with structures on both sides does not need to undergo a glass thinning process and saves a lot of cost compared to the traditional glass or Si interposer processes. Thin 300-mm glass wafers 100 μm thick are evaluated as: (a) blank thin glass wafers and (b) thin glass wafers with through-glass vias (TGVs) 30 μm in diameter. A UV laser with a wavelength of 308 nm, which has the benefit of less impact to the device, was adopted to laser debonding. This method also has several benefits such as high throughput, low temperature, zero-force debonding, and possible selective laser debonding. Adhesive and release layers are key enabling materials for thin glass handling. In addition, the use of a laminator for temporary bonding and laser debonding are included in this study. Based on the excellent fabrication, the thin glass interposer has great potential to be applied in 2.5-D integration applications.
Dynamics of Human Milk Oligosaccharides in early lactation and relation with growth and appetitive traits of Filipino breastfed infants (2022)

Abstract Human milk oligosaccharides (HMOs) play a key role in the maturation of the infant gut microbiome and immune system and are hypothesized to affect growth. This study examined the temporal changes of 24 HMOs and their associations to infant growth and appetitive traits in an exploratory, prospective, observational, study of 41 Filipino mother-infant dyads. Exclusively breastfed, healthy, term infants were enrolled at 21–26 days of age (≈ 0.75 mo) and followed for 6 months. Infant growth measures and appetitive traits were collected at visit 1 (V1) (≈ 0.75 mo), V2 (≈ 1.5 mo), V3 (2.5 mo), V4 (2.75 mo), V5 (4 mo), and V6 (6 mo), while HMOs were measured at V1, V2, V4 and V6. Overall exposure to each HMO was summarized as area under the curve from baseline to 4 months of age and examined in association with each measure of growth at 6 months using linear regression adjusted for maternal age at birth, infant sex, birth weight, and mode of delivery. We saw modest associations between several HMOs and infant growth parameters. Our results suggest that specific HMOs, partly as proxy for milk groups (defined by Secretor and Lewis status), may be associated with head circumference and length, increasing their relevance especially in populations at the lower end of the WHO growth curve. We did not identify the same HMOs associated with infant appetitive traits, indicating that at least in our cohort, changes in appetite were not driving the observed associations between HMOs and growth. Clinical trial registration: NCT03387124
Coordinated Resource management in a Replicated Object Server (1994)

We propose several new techniques for resource management in a replicated object server. By coordinating cache and disk usage among the replicas, these techniques increase throughput and reduce fetch latency. Cache splitting speeds up fetches by avoiding redundant cache entries, effectively increasing the cache size. Coordinated writing coordinates disk writes to ensure that one replica is always available to service fetches. We investigate the performance of a replicated server using these techniques, and we present simulation results showing that these techniques provide substantial performance improvements across a variety of workloads. 1 Introduction Traditional replicated server designs use multiple replicas to improve system availability and reliability. Although close communication between the replicas is required for transaction serialization, each replica independently manages its cache memory and disk resources. In this paper we propose new techniques that exploit a previo...
Activation of αVβ3 on Vascular Cells Controls Recognition of Prothrombin (1998)

Regulation of vascular homeostasis depends upon collaboration between cells of the vessel wall and blood coagulation system. A direct interaction between integrin alphaVbeta3 on endothelial cells and smooth muscle cells and prothrombin, the pivotal proenzyme of the blood coagulation system, is demonstrated and activation of the integrin is required for receptor engagement. Evidence that prothrombin is a ligand for alphaVbeta3 on these cells include: (a) prothrombin binds to purified alphaVbeta3 via a RGD recognition specificity; (b) prothrombin supports alphaVbeta3-mediated adhesion of stimulated endothelial cells and smooth muscle cells; and (c) endothelial cells, either in suspension and in a monolayer, recognize soluble prothrombin via alphaVbeta3. alphaVbeta3-mediated cell adhesion to prothrombin, but not to fibrinogen, required activation of the receptor. Thus, the functionality of the alphaVbeta3 receptor is ligand defined, and prothrombin and fibrinogen represent activation- dependent and activation-independent ligands. Activation of alphaVbeta3 could be induced not only by model agonists, PMA and Mn2+, but also by a physiologically relevant agonist, ADP. Inhibition of protein kinase C and calpain prevented activation of alphaVbeta3 on vascular cells, suggesting that these molecules are involved in the inside-out signaling events that activate the integrin. The capacity of alphaVbeta3 to interact with prothrombin may play a significant role in the maintenance of hemostasis; and, at a general level, ligand selection by alphaVbeta3 may be controlled by the activation state of this integrin.
Direct measurement of peptidoglycan cross-linking in bacteria by 15N nuclear magnetic resonance. (1983)

Cross-polarization magic angle spinning 9.12-MHz 15N nuclear magnetic resonance was used to measure the extent of peptidoglycan cross-linking within intact bacterial cells and isolated cell walls of Aerococcus viridans ATCC 10400 grown in the presence of L-[epsilon-15N]lysine. A value of 49% for the cross-linking index was found for normal cells, while for those grown in the presence of low levels of penicillin G (0.1 micrograms/ml), the cross-linking index was reduced to 35%.
Identification of Targets of a New Nutritional Mixture for Osteoarthritis Management Composed by Curcuminoids Extract, Hydrolyzed Collagen and Green Tea Extract (2016)

The COT mixture has beneficial effect on osteoarthritis physiopathology by regulating the synthesis of key catabolic, inflammatory and angiogenesis factors. These findings give a scientific rationale for the use of these natural ingredients in the management of osteoarthritis.