gebhart/patrepeval huggingface dataset:
Étude des alcaloïdes de Guatteria discolor : isolement, détermination structurale, approche synthétique (1987)

La composition alcaloidique des ecorces de Guatteria discolor a ete etudiee. Dix-huit alcaloides ont ete isoles. Onze sont nouveaux : la demethyl-10 discretine, tetrahydroprotoberberine; la N-oxyatherosperminine, phenanthrene; la saxoguattine, deuxieme exemple de dimethylaminoethylbenzile; la discoguattine et l'isocalycinine, noraporphines disubstituees en 9 et 11; l'oxoisocalycinine; la guadiscine, la guadiscidine et la guadiscoline, de type original, les dimethyl-7,7 dehydro-6,6a aporphines; la guacoline et la guacolidine, hydroxy-7 methyl-7 dehydro-6,6a aporphines. Des hypotheses de biogenese de ces aporphines sont proposees. La synthese des aporphines hydroxylees en 7 et methylees en 7, isolees precedemment, a ete abordee par une nouvelle voie, celle des composes de dihydro­ REISSERT. L'etude de la reactivite de ces produits, peu developpee jusqu'alors, a ete realisee en particulier en milieu alcalin. Ces derives se comportent differemment des composes de REISSERT dont l'utilisation dans la synthese des alcaloides isoquinoleiques est usuelle. Cette reactivite particuliere a ete appliquee a la synthese des benzyl­ isoquinoleines methylees et hydroxylees sur le carbone benzylique, precurseurs synthetiques de ces aporphines. Des hypotheses de mecanisme de ces reactions sont proposees.
Self‐Sealing of Nanoporous Low Dielectric Constant Patterns Fabricated by Nanoimprint Lithography (2008)

The cross-sectional TEM image shows that line-space patterns can be directly imprinted, with high fidelity, into highly porous spin-on organosilicate materials. This publication quantifies how the porosity and distribution of pores within the patterns are affected by the nanoimprint lithography processes, including evidence for a densified pattern surface.
How do transtibial residual limbs adjust to intermittent incremental socket volume changes? (2019)

Results support the hypothesis that for people without co-morbidities, intermittent incremental socket volume enlargements are an effective accommodation strategy to increase limb fluid volume while maintaining socket fit. Intermittent incremental socket volume reductions decreased limb fluid volume but also made the socket fit tighter.
Chemical recovery of spent copper powder in laser powder bed fusion (2022)

In laser powder bed fusion (LPBF), recovered unfused powder from the powder bed often degrades upon sequential processing through mechanisms like thermal oxidation and particle satelliting from ejected weld spatters and particle-laser interactions. Given the sensitivity of LPBF performance and build quality to powder properties, spent powder is generally discarded after a few build cycles, especially for materials that are sensitive towards surface oxidation. This increases feedstock material costs, as well as costs associated with machine downtime during powder replacement. Here, a new method to chemically reprocess spent LPBF metal powder is demonstrated under ambient conditions, using a heavily oxidised Cu powder feedstock recovered from prior LPBF processing as a model material. This is compared to an equivalent virgin Cu powder. The near-surface powder chemistry has been analysed, and it is shown that surface oxide layers present on spent Cu powder can be effectively reset after rapid reprocessing (from 5 to 20 min). Diffuse reflectance changes on etching, reducing for gas-atomised virgin Cu powder due to the formation of anisotropic etch facets, and increasing for heavily oxidised spent Cu as the highly absorptive oxide layers are removed. The mechanism of powder degradation for moisture sensitive materials like Cu has been correlated to the degradation of LPBF deposits, which manifests as widespread and extensive porosity. This extensive porosity is largely eliminated after reprocessing the spent Cu powder. Chemically etched spent powder is therefore demonstrated as a practical feedstock in LPBF in which track density produced is comparable to virgin powder.
Highly sensitive asymmetric long period fiber grating over 1545 ~ 1650 nm using optical polymer on deep-ablated cladding (2007)

We demonstrate high temperature-sensitive, wideband-tunable, laser-ablated asymmetric long period fiber gratings with optical polymer overlay. The temperature sensitivity can be as high as 15.8 nm/degC over a wide spectral range from 1545 to 1650 nm.
Dual-wavelength superfluorescent fiber emitter (1997)

The feasibility of constructing a dual-wavelength, spatially single-mode, superfluorescent fiber emitter on the basis of erbium optical fibers with pumping by multimode semiconductor lasers is demonstrated. The emitter is fabricated by all-fiber technology and has a power output in excess of 10 mW, an average emission wavelength of 1.54 μm, and a spectral resolution of 27.5 nm at component linewidths of 3 nm and 9 nm. The depolarization of the radiation from the emitter as it propagates in an anisotropic, single-mode fiber waveguide is investigated.
Prf immune complexes of tomato are oligomeric and contain multiple Pto‐like kinases that diversify effector recognition (2009)

Cytoplasmic recognition of pathogen virulence effectors by plant NB-LRR proteins leads to strong induction of defence responses termed effector triggered immunity (ETI). In tomato, a protein complex containing the NB-LRR protein Prf and the protein kinase Pto confers recognition of the Pseudomonas syringae effectors AvrPto and AvrPtoB. Although structurally unrelated, AvrPto and AvrPtoB interact with similar residues in the Pto catalytic cleft to activate ETI via an unknown mechanism. Here we show that the Prf complex is oligomeric, containing at least two molecules of Prf. Within the complex, Prf can associate with Pto or one of several Pto family members including Fen, Pth2, Pth3, or Pth5. The dimerization surface for Prf is the novel N-terminal domain, which also coordinates an intramolecular interaction with the remainder of the molecule, and binds Pto kinase or a family member. Thus, association of two Prf N-terminal domains brings the associated kinases into close promixity. Tomato lines containing Prf complexed with Pth proteins but not Pto possessed greater immunity against P. syringae than tomatoes lacking Prf. This demonstrates that incorporation of non-Pto kinases into the Prf complex extends the number of effector proteins that can be recognized.
[Role of TGF beta 1 in the stromal reaction to human colonic tumors]. (1993)

Two types of human fibroblasts have been isolated from a patient with a colon cancer with metastasis, one type was derived from a healthy part of the colon, and the other one isolated from a metastasized lymph node close to the intestine. These fibroblasts have been characterized for their expression of collagens type I, III and IV, vimentin, fibronectin, alpha-smooth muscle actin, laminin and desmin. The effects of conditioned media of human colon cancer cell lines, HT29, SW1116, LS180 and HCT8R, on the metabolism of these fibroblasts were tested. All the conditioned media stimulate both types of fibroblasts, as reflected by their incorporation of radiolabelled methionine and proline. Normal fibroblasts were highly sensitive to the conditioned media as compared to the activated fibroblasts. Additionally, the production of TGF beta 1 by the four colorectal cancer cell lines has been quantified, and significant qualitative (production of latent and/or active form) and quantitative differences were observed. The effects of the conditioned media of the four tumoral cell lines and exogenous TGF beta 1 on the proliferation of the two types of fibroblasts were compared. Our data indicated that the two types of fibroblasts respond differently to TGF beta 1 whereas they are both growth stimulated by the conditioned media, apart from the LS180 conditioned medium. We conclude that if TGF beta 1 acts in the fibroblastic reaction, additional factors are required.
Time-, Energy-, and Phase-Resolved Second-Harmonic Generation at Semiconductor Interfaces (2014)

Interfacial charge transfer is ubiquitous in many chemical and physical processes and can occur on ultrafast time scales of femtoseconds to picoseconds. Probing dynamics on such time scales necessitates the use of ultrafast laser spectroscopies, but signatures of interfacial charge transfer can be overwhelmed by the signal from bulk materials. This problem may be alleviated in second-harmonic generation, which can be specifically sensitive to interfacial charge transfer if other bulk and interfacial contributions to the measured second-harmonic signal can be resolved. We report the development of a femtosecond spectral interferometry technique for second-harmonic generation with time, energy, and phase resolution. Using the model systems of a passivated GaAs(100) surface and copper phthalocyanine/GaAs(100) interface, we demonstrate the application of this technique in unveiling the rich dynamics of band renormalization, charge carrier motion, and interfacial charge transfer, all induced by across-bandgap optical excitation of the semiconductor.
On the Road Towards Ca-Based Batteries (2016)

The development of a rechargeable battery technology using light electropositive metal anodes would bring in a breakthrough in energy density, especially if it involves multivalent charge carriers. While effective electrolytes have been developed for magnesium which has enabled to achieve proof-of-concept for magnesium batteries, the electrodeposition of calcium was thought to be impossible and research restricted to non rechargeable systems. Calcium is an especially attractive alternative as it is the fifth most abundant element on earth crust and its standard reduction potential is only 170 mV above that of lithium, enabling significantly larger cell potential than that achievable with magnesium or aluminium. The talk will revisit these aspects discussing the feasibility of reversible calcium plating/stripping using conventional alkylcarbonate electrolytes which impacts the prospects of developing a new calcium based rechargeable battery technology.
Advances in Diagnostic and Intraoperative Molecular Imaging of Pancreatic Cancer (2018)

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. To improve outcomes, there is a critical need for improved tools for detection, accurate staging, and resectability assessment. This could improve patient stratification for the most optimal primary treatment modality. Molecular imaging, used in combination with tumor-specific imaging agents, can improve established imaging methods for PDAC. These novel, tumor-specific imaging agents developed to target specific biomarkers have the potential to specifically differentiate between malignant and benign diseases, such as pancreatitis. When these agents are coupled to various types of labels, this type of molecular imaging can provide integrated diagnostic, noninvasive imaging of PDAC as well as image-guided pancreatic surgery. This review provides a detailed overview of the current clinical imaging applications, upcoming molecular imaging strategies for PDAC, and potential targets for imaging, with an emphasis on intraoperative imaging applications.
Metallic Conductive Nanowires Elaborated by PVD Metal Deposition on Suspended DNA Bundles (2017)

Metallic conductive nanowires (NWs) with DNA bundle core are achieved, thanks to an original process relying on double-stranded DNA alignment and physical vapor deposition (PVD) metallization steps involving a silicon substrate. First, bundles of DNA are suspended with a repeatable process between 2 µm high parallel electrodes with separating gaps ranging from 800 nm to 2 µm. The process consists in the drop deposition of a DNA lambda-phage solution on the electrodes followed by a naturally evaporation step. The deposition process is controlled by the DNA concentration within the buffer solution, the drop volume, and the electrode hydrophobicity. The suspended bundles are finally metallized with various thicknesses of titanium and gold by a PVD e-beam evaporation process. The achieved NWs have a width ranging from a few nanometers up to 100 nm. The electrical behavior of the achieved 60 and 80 nm width metallic NWs is shown to be Ohmic and their intrinsic resistance is estimated according to different geometrical models of the NW section area. For the 80 nm width NWs, a resistance of about few ohms is established, opening exploration fields for applications in microelectronics.
Rapamycin Generates Graft-Homing Murine Suppressor CD8+T Cells That Confer Donor-Specific Graft Protection (2011)

It has been reported that rapamycin (RPM) can induce de novo conversion of the conventional CD4(+)Foxp3(-) T cells into CD4(+)Foxp3(+) regulatory T cells (iTregs) in transplantation setting. It is not clear whether RPM can similarly generate suppressor CD8(+) T cells to facilitate graft acceptance. In this study, we investigated the ability of short-term RPM treatment in promoting long-term acceptance (LTA) of MHC-mismatched skin allografts by generating a CD8(+) suppressor T-cell population. We found that CD4 knockout (KO) mice (in C57BL/6 background, H-2(b)) can promptly reject DBA/2 (H-2(d)) skin allografts with mean survival time (MST) being 13 days (p < 0.01). However, a short course RPM treatment in these animals induced LTA with graft MST longer than 100 days. Adoptive transfer of CD8(+) T cells from LTA group into recombination-activating gene 1 (Rag-1)-deficient mice provided donor-specific protection of DBA/2 skin grafts against cotransferred conventional CD8(+) T cells. Functionally active immunoregulatory CD8(+) T cells also resided in donor skin allografts. Eighteen percent of CD8(+) suppressor T cells expressed CD28 as measured by flow cytometry, and produced reduced levels of IFN-γ, IL-2, and IL-10 in comparison to CD8(+) effector T cells as measured by ELISA. It is unlikely that CD8(+) suppressor T cells mediated graft protection via IL-10, as IL-10/Fc fusion protein impaired RPM-induced LTA in CD4 KO mice. Our data supported the notion that RPM-induced suppressor CD8(+) T cells home to the allograft and exert donor-specific graft protection.
Segmentation of Knee Thermograms for Detecting Inflammation (2019)

Rheumatologists determine treatment plan based on the inflammation of knee joints affected by arthritis. Extraction of the inflamed region or hotspot from the knee thermogram is the prerequisite for grading of inflammation and classification of different arthritis. In this paper, we propose an automatic method for extracting the inflamed region from the knee thermograms. We propose an ensemble technique to arrive at a consensus segmentation of the hotspot region. We have used variation of information based information theoretic approach to generate consensus segmentation. The fusion of multiple segmentation maps is achieved using local search based greedy iterated conditional modes algorithm to obtain final segmentation result. Experiments show that our proposal scores significantly better in detecting hotspots in more than 50 inflammatory knee thermograms.
Tumor invasion and metastasis. (1986)

A metastatic colony is the end result of a complicated series of tumor—host interactions.1,2 Potential mechanisms underlying this complex process are outlined in Table I. In this regard, primary tumor initiation and promotion are followed by the transition from in situ to locally invasive cancer and angiogenesis.3–6 Newly formed tumor vessels are often defective and easily invaded by tumor cells within the primary mass. At the invasion front, tumor cells also invade pre-established host blood vessels. Tumor cells are discharged into the venous drainage in single cell form and in clumps. For rapidly growing tumors 1 cm in size, millions of tumor cells can be shed into the circulation every day. Fortunately for the patient, only a very small percentage (< .01%) of circulating tumor cells initiate metastatic colonies. Tumors generally lack a well-formed lymphatic network. Therefore, communication of tumor cells with lymphatic channels occurs only at the tumor periphery and not within the tumor mass. Tumor cells entering the lymphatic drainage are carried to regional lymph nodes where they arrest in the subcapsular sinus. Within 10–60 min after initial arrest in the lymph node, a significant fraction of the tumor cells detach and enter the efferent lymphatics. These tumor cells eventually end up in the regional or systemic venous drainage due to the existence of numerous lymphatic—hematogenous communications. Thus, the regional lymph node does not function as a true mechanical barrier to tumor dissemination. Lymphatic and hematogenous dissemination occurs in parallel (see also Chapter 28).
A multilevel analog storage memory using source-side injection flash array (2003)

A multilevel storage technology with resolution approaching 8-bits is developed for storing analog signals directly into a memory array of source-side injection flash EEPROM. This is achieved by devising a read and programming scheme, by optimizing a memory cell layout, and by integrating mixed-mode capabilities into the base digital flash process.
Simple Loran Cycle Error Detection Algorithms for Maritime Harbor Entrance Approach Operations (2010)

Enhanced Loran (eLoran) is designed to support maritime harbor entrance approach (HEA) operations. As a result, the Radio Technical Commission for Maritime Services (RTCM) special committee 127 (SC127) is developing minimum performance specifications (MPS) for HEA eLoran receiver. The MPS specify required algorithms and processes to ensure safe operations of the receiver. One important algorithm is the high integrity determination of the tracked Loran cycle. This paper details and examines some of the algorithms being developed and analyzed by SC127. SC 127 is developing simplified eLoran cycle error detection algorithms for the eLoran HEA MPS. Correct Loran cycle selection is needed to ensure safety as a cycle selection error results in range errors of 3 km or more. As HEA operations require accuracy levels of 10 meters, such errors pose a significant hazard. While other high integrity Loran cycle error detection algorithms have been proposed, these are require complex calculations and significant processing. The use of differential Loran in HEA supported areas can be leveraged to create a significantly simpler algorithm allowing for easier and lower cost implementation. This paper develops and examines two simplified algorithms for cycle error detection for HEA. These algorithms use receiver autonomous integrity monitoring (RAIM) basic techniques of residual error and solution separation. The paper describes the algorithms, their implementation and demonstrates its capabilities in the conterminous United States (CONUS). The goal of the work is to provide and demonstrate feasible algorithms for manufacturers to use for their MPS compliant HEA receiver.
Liquid-Nitrogen-Cooled Dry Etching of YBaCuO Thin Films (1992)

A new dry etching method has been developed for patterning YBaCuO thin films with less damage, wherein samples are cooled by liquid nitrogen. It is found that the critical current density J c of films etched by this cooling method is significantly improved, more than one order of magnitude higher than that for the films etched at 5°C. Furthermore, it is found that this technique causes less damage to the surface of the YBaCuO films, compared to the etching at 5°C. This result suggests that the dry etching process with liquid nitrogen cooling is a promising method for the fabrication of high- T c superconducting electronic devices of small dimensions.
Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors (2010)

Hepcidin is a liver-derived hormone with a key role in iron homeostasis. In addition to iron, it is regulated by inflammation and hypoxia, although mechanisms of hypoxic regulation remain unclear. In hepatocytes, hepcidin is induced by bone morphogenetic proteins (BMPs) through a receptor complex requiring hemojuvelin (HJV) as a co-receptor. Type II transmembrane serine proteinase (TMPRSS6) antagonizes hepcidin induction by BMPs by cleaving HJV from the cell membrane. Inactivating mutations in TMPRSS6 lead to elevated hepcidin levels and consequent iron deficiency anemia. Here we demonstrate that TMPRSS6 is up-regulated in hepatic cell lines by hypoxia and by other activators of hypoxia-inducible factor (HIF). We show that TMPRSS6 expression is regulated by both HIF-1α and HIF-2α. This HIF-dependent up-regulation of TMPRSS6 increases membrane HJV shedding and decreases hepcidin promoter responsiveness to BMP signaling in hepatocytes. Our results reveal a potential role for TMPRSS6 in hepcidin regulation by hypoxia and provide a new molecular link between oxygen sensing and iron homeostasis.
Metabolomics Strategy Reveals Subpopulation of Liposarcomas Sensitive to Gemcitabine Treatment (2012)

Patients with high-grade liposarcoma have poor prognoses and often fail to respond to chemotherapy. This report identifies elevated nucleoside salvage activity in a subset of liposarcomas that are identifiable using noninvasive PET imaging with FAC and that are sensitive to gemcitabine. Thus, we suggest a new treatment paradigm for liposarcoma patients that uses [18F]-FAC-PET in the clinic to delineate gemcitabine responders from nonresponders.
P-P43 Lymph Node Negative Duodenal Adenocarcinoma Is Associated with Long-term Patient Survival following Pancreaticoduodenal Resection (2021)

Abstract Background Duodenal adenocarcinoma (DA) is a rare gastrointestinal malignancy. Due to the low incidence of DA there is limited data reporting patient outcomes following radical pancreatic resection. Large retrospective single and multi-centre studies suggest that lymph node metastasis is an important factor for long-term patient survival following resection. The management of DA has tended to favour aggressive surgical resection with pancreaticoduodenectomy (PD), although a morbidity of up to 50% has been reported, mostly related to post-operative pancreatic fistulas. We assessed the disease-free (DFS) and overall survival (OS) in patients undergoing pancreaticoduodenectomy for DA in our institution. Methods We retrospectively analysed all patients undergoing pancreatic resection for DA at our institution between January 2009 – March 2020 inclusive. All DAs were cytologically or histologically proven prior to surgical resection following imaging review in a Hepato-pancreaticobiliary multidisciplinary team meeting. Patients underwent a Whipple’s with distal gastrectomy or pylorus preserving pancreaticoduodenectomy (PPPD) based on tumour size and location. Statistical analysis was performed by a Mann-Whitney U test using a p-value significance of 0.05 (SPSS, IBM, USA). DFS and OS curves were presented by Kaplan- Meier survival curves. Results 19 patients underwent pancreatic resection at our institution for DA during the study period. 12 patients underwent Whipple’s with distal gastrectomy and 9 patients underwent PPPD. The overall postoperative morbidity and mortality was 37% and 5% respectively. R0 resection was achieved in 18 patients (95%). 9 patients (47%) had no nodal involvement. Median follow up was 31 months (range 1-108 months). Median DFS was 17 months but was significantly higher in patients with no nodal metastasis [p &amp;lt; 0.001]. Median OS was 9.5 months for the whole cohort but was significantly higher in the patients with no nodal vs nodal metastasis (60 vs 17.5 months respectively) p &amp;lt; 0.003]. Conclusions DA can be resected by PD or segmental resection. PD is favoured due to improved resection margins and overall increased patient survival, despite an increased morbidity. Our series reports comparable morbidity and mortality to the published literature for DA resected by PD. This study reports a 95% R0 resection rate for DA with a 3- and 5-year survival of 50% and 30% respectively. DFS was found to be significantly higher in patients with no nodal disease, despite predominant T4 disease. This series has identified that lymph node metastasis is one of the most important prognostic determinants of long-term patient survival. Program permission yes