gebhart/patrepeval huggingface dataset:
PlexiChain: A Secure Blockchain-based Flexibility Aggregator Framework (2022)

Flexible resources in built environments are seen as a low-cost opportunity for delivering grid management services. Consequently, the centralised aggregator model, where the aggregator is used to bundle demand flexibility from flexible resources and deliver it to flexibility customers such as Distributed/Transmission System Operator (DSO/TSO) in flexibility markets, has been adopted. However, the aggregator role introduces various security and trust challenges. In this work, we propose a blockchain-based flexibility trading framework dubbed PlexiChain to address the security and trust challenges the aggregator poses in the centralised aggregator model. The security evaluations performed using a real-world dataset show that PlexiChain is robust against known security attacks, such as MadIoT and False Data Injection attacks. Additionally, the performance evaluations show that PlexiChain has lower computation and communication costs than other blockchain-based applications in resource-constrained environments.
Gentherapie am Beispiel der Chronischen Granulomatose (2002)

No translation.
Selective Hydrogenation of 1,3‐Butadiene and 1‐Butyne over a Rh/Chitosan Catalyst Investigated by using Parahydrogen‐Induced Polarization (2012)

Abstract Hydrogenation of 1,3‐butadiene and 1‐butyne over the Rh/chitosan catalyst in gaseous and liquid phases was investigated by using the NMR and parahydrogen‐induced polarization technique. The Rh/chitosan system was a very selective catalyst for the partial hydrogenation of 1,3‐butadiene and 1‐butyne to 1‐ and 2‐butenes. The catalyst demonstrated high activity in the hydrogenation of 1‐butyne after its activation in the hydrogenation of 1,3‐butadiene. Therefore, the Rh/chitosan catalyst was used for the catalytic removal of 1,3‐butadiene and 1‐butyne from gaseous butene streams. Moreover, the syn ‐ and anti ‐addition of the hydrogen molecule to substrates proceeded in a pairwise manner in the gas phase heterogeneous hydrogenation as was demonstrated by parahydrogen‐induced polarization. However, in the liquid phase hydrogenation of 1‐butyne, both hydrogen atoms from the same hydrogen molecule were added to 1‐butyne only through the syn ‐addition route.
Modeling and controller design of ICPT pick-ups (2003)

Inductively coupled power transfer (ICPT) systems rely on effective control and dynamic analysis of pick-up loads for stable operation. However, such analytical analysis is complex due to the presence of high order, AC resonant circuits and this makes the controller design much more difficult. This paper proposes a novel equivalent DC circuitry method to analyze the dynamic response of high frequency AC resonant converter pick-up circuits in ICPT systems. The equivalent validity is proven with Pspice simulation results. The pick-up controller is developed based on the analysis of the equivalent DC model of a parallel tuned pick-up circuit. This allows simple closed form analytical expressions to be developed for different controller options.
Characterization of mechanically induced surface damage on the implant alloy TiAl6Nb7 in quasi-physiological media (2002)

To characterize mechanically induced surface damage scratch and rotating bending tests were performed on the implant alloy TiAl6Nb7 with different surface conditions (polished, thermally oxidized, anodically oxidized) in Hank's solution and in newborn calf serum at 37°C. The surface processes taking place during repassivation or due to the fatigue loading were identified by measuring the free corrosion current and potential. Light and scanning electron microscopic investigations were used to correlate surface changes with the results of the electrochemical measurements. Charakterisierung von Oberflächemschäden der Implantatlegierung TiAI6Nb7 nach mechanischer Beansruchung in quasi-physiologischen Medien Zur Charakterisierung mechanisch induzierter Oberflächenschäden wurden Ritzversuche sowie Umlaufbiegeversuche an der Implantatlegierung TiAl6Nb7 mit unterschiedlichen Oberflächenzuständen (poliert, thermisch oxidiert, anodisch oxidiert) in Hanklösung bzw. in Kälberserum bei 37°C durchgeführt. Die während der Repassivierung bzw. aufgrund der Ermüdungsbeanspruchung an der Oberfläche ablaufenden Prozesse wurden durch Messung des freien Korrosionstroms bzw. Korrosionspotentials erfasst. Mit Hilfe licht- und rasterelektronenmikroskopischer Verfahren wurden die durch Ritzen eingebrachten bzw. ermüdungsbedingten Oberflächenveränderungen sowie deren Wechselwirkung mit den physiologischen Medien mit den Ergebnissen der elektrochemischen Messungen korreliert.
545 Tumor-specific cytolytic CD4 T cells mediate protective immunity against human cancer (2020)

<h3>Background</h3> CD4 T cells have been implicated in cancer immunity for their helper functions. However, their direct cytotoxic potential remains elusive in cancer patients. Here, we aimed at assessing the presence, rate and cytotoxic function of tumor-specific Th-CTX directly in cancer patients. <h3>Methods</h3> We capitalized on published single cell transcriptomic analyses of patient samples, integrated with the direct phenotypic and functional characterization of clonal, tumor-specific CD4 T cell populations, using peptide-MHC class II multimers and a novel high-throughput single-cell cytotoxicity assay in picowell arrays. The direct tumor cell killing by cytolytic tumor-specific CD4 T cells in the arrays was monitored in a high-throughput manner by combining multi-channel time-lapse microscopy with deep neural networks. <h3>Results</h3> By mining single-cell RNA-seq datasets of tumor infiltrating lymphocytes, we identified CD4 T cells displaying cytotoxic phenotypes in different human tumors. The cytolytic CD4 T cells formed a distinct cluster and expressed genes related to classical cytotoxic functions, largely resembling CD8 T cell gene profiles. Using the peptide MHC class II multimer technology, we confirmed directly ex vivo the presence of cytolytic tumor antigen-specific CD4 T cells, both in the circulation and in the tumors of patients. We performed an integrated phenotypic and functional characterization of cytolytic tumor-specific CD4 T cells, down to the single cell level, through a high-throughput nanobiochip consisting of massive arrays of picowells with sub-nanoliter volumes and machine learning. We demonstrated a direct, contact-dependent, granzyme-dependent cytotoxic activity against tumor cells, with delayed kinetics compared to classical cytotoxic lymphocytes. Lastly, we discovered that this cytotoxic activity was at least in part dependent on the expression of SLAMF7, a homophylic receptor known to regulate NK cell activity. <h3>Conclusions</h3> Our work provides a deep characterization of human Th-CTX in cancer and supports their role in tumor immunity. Moreover, our results showing that agonistic engagement of SLAMF7 enhances the cytolytic capacity of tumor-specific CD4 T cells, suggests that targeting these cells might prove synergistic with the use of other immunotherapies in cancer patients.
Support and Profiles of Nonoffending Mothers of Sexually Abused Children (2013)

Maternal support offered to sexually abused children following disclosure may be a crucial factor in children's recovery. A person-centered approach was used to examine how profiles of nonoffending mothers could better describe their ability to support their children after disclosure. Cluster analyses based on a total of 226 nonoffending mothers recruited from child protective services yielded four distinctive groups of mothers: resilient, avoidant-coping, traumatized, and anger-oriented reaction. These profiles differed on measures of support, parenting, and variables related to attitude following disclosure. The discussion underscores the relevance of adopting a tailored approach to intervention with mothers of sexually abused children.
AsMA Medical Guidelines for Air Travel: Airline Special Services (2015)

Medical Guidelines for Airline Travel provide information that enables healthcare providers to properly advise patients who plan to travel by air. Treating physicians should advise patients in need of special services to contact the airline well before travel to find out if the required services will be available. Ensuring the required services are available throughout a journey can be challenging, especially when different airlines and aircraft types are involved. For example, airlines carry a limited supply of oxygen for use in the event of an unexpected in-flight emergency; however, this supply is not intended for use by passengers needing supplemental oxygen. Arrangements must be made in advance with the airline. Therefore, early contact with the airline is helpful.
The fabrication of 20 nm half-pitch gratings by corrugation-directed self-assembly (2008)

The evolution of the scaling of modern semiconductor devices is governed by the ability to create scalable high-resolution patterns on substrates. Since it is becoming increasingly difficult and expensive to extend to smaller dimensions using optical lithography, there is a great deal of interest in alternative patterning methods. The self-assembly of block copolymers in thin films, which provides periodic patterns of 10-50 nm length scales, has been recognized as a promising candidate for such patterning. To be practical, however, this approach must provide control over the orientation and lateral placement of the microdomains. We report here our discovery of the controlled alignment of the lamellar microdomains of a block copolymer containing hybrid material using topographic pre-patterns on substrates. We find that this hybrid material forms lamellae with a half-pitch of approximately 20 nm perpendicular to the lines of a surface corrugation.
A687V EZH2 Is a Driver of Histone H3 Lysine 27 (H3K27) Hypertrimethylation (2014)

The EZH2 methyltransferase silences gene expression through methylation of histone H3 on lysine 27 (H3K27). Recently, EZH2 mutations have been reported at Y641, A677, and A687 in non-Hodgkin lymphoma. Although the Y641F/N/S/H/C and A677G mutations exhibit clearly increased activity with substrates dimethylated at lysine 27 (H3K27me2), the A687V mutant has been shown to prefer a monomethylated lysine 27 (H3K27me1) with little gain of activity toward H3K27me2. Herein, we demonstrate that despite this unique substrate preference, A687V EZH2 still drives increased H3K27me3 when transiently expressed in cells. However, unlike the previously described mutants that dramatically deplete global H3K27me2 levels, A687V EZH2 retains normal levels of H3K27me2. Sequencing of B-cell-derived cancer cell lines identified an acute lymphoblastic leukemia cell line harboring this mutation. Similar to exogenous expression of A687V EZH2, this cell line exhibited elevated H3K27me3 while possessing H3K27me2 levels higher than Y641- or A677-mutant lines. Treatment of A687V EZH2-mutant cells with GSK126, a selective EZH2 inhibitor, was associated with a global decrease in H3K27me3, robust gene activation, caspase activation, and decreased proliferation. Structural modeling of the A687V EZH2 active site suggests that the increased catalytic activity with H3K27me1 may be due to a weakened interaction with an active site water molecule that must be displaced for dimethylation to occur. These findings suggest that A687V EZH2 likely increases global H3K27me3 indirectly through increased catalytic activity with H3K27me1 and cells harboring this mutation are highly dependent on EZH2 activity for their survival.
ChemInform Abstract: Benzotriazole‐Mediated Synthesis of N‐Alkyl‐N,N′‐diarylhydrazines. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mathematical Modeling of a Bioluminescent E. Coli Based Biosensor (2009)

In this work we present a mathematical model for the bioreporter activity of an E. coli based bioluminescent bioreporter. This bioreporter is based on a genetically modified E. coli which harbors the recA promoter, a member of the bacterial SOS response, fused to the bacterial luminescence (lux) genes. This bioreporter responds to the presence of DNA damaging agents such as heavy metals, H2O2 and Nalidixic Acid (NA) that activate the SOS response. In our mathematical model we implemented basic physiological mechanisms such as: the penetration of the NA into the biosensor; gyrase enzyme inhibition by the NA; gyrase level regulation; creation of chromosomal DNA damage; DNA repair and release of ssDNA into the cytoplasm; SOS induction and chromosomal DNA repair; activation of lux genes by the fused recA promoter carried on a plasmidal DNA; transcription and translation of the luminescence responsible enzymes; luminescence cycle; energy molecules level regulation and the regulation of the O2 consumption. The mathematical model was defined using a set of ordinary differential equations (ODE) and solved numerically. We simulated the system for different concentrations of NA in water for specific biosensors concentration, and under limited O2 conditions. The simulated results were compared to experimental data and satisfactory matching was obtained. This manuscript presents a proof of concept showing that real biosensors can be modeled and simulated. This sets the ground to the next stage of implementing a comprehensive physiological model using experimentally extracted parameters. Following the completion of the next stage, it will be possible to construct a “Computer Aided Design” tool for the simulation of the genetically engineered biosensors. We define a term “bioCAD” for a Biological System Computer Aided Design. The specific bioCAD that is described here is aimed towards whole cell biosensors which are under investigation today for functional sensing. Usage of the bioCAD will improve the biosensors design process and boost their performance. It will also reduce Non Recurring Engineering (NRE) cost and time. Finally, using a parameterized solution will allow fair and quick evaluation of whole cell biosensors for various applications.
Single vs. Dual Recycle System Requirements in the Design of High Pressure Ratio, Low Inertia Centrifugal Compressor Stations (2011)

Compression systems are designed and operated in a manner to eliminate or minimize the potential for surge, which is a dynamic instability that is very detrimental to the integrity of the compressor unit. Compressor surge can occur when compressors are subjected to rapid transients such as those occurring following an emergency shutdown (ESD) or a power failure, which in turn, requires fast reaction. To prevent this from occurring, compressor stations are designed with single or dual recycle systems with recycle valves, which are required to open upon ESD. There has been extensive debate and confusion as to whether a single recycle or a dual recycle system is required and the circumstances and the conditions under which one system or the other must be used. This paper discusses this crucial design issue in detail and highlights the parameters affecting the decision to employ either system, particularly for high pressure ratio, low inertia compressors. Parameters such as gas volume capacitance (V) in the recycle path, compressor power train inertia, compressor performance characteristics, the recycle valve coefficient (Cv), pre-stroke and stroke time, and check valve dynamic characteristic are crucial in determining the conditions for dynamic instabilities. A simple analytical methodology based on the perturbation theory is developed that provides a first-cut analysis to determine if a single recycle system is adequate for a given compression system. The concept of an inertia number is then introduced with a threshold value that determines which recycle system to use. Techniques to circumvent compressor surge following ESD are discussed and their respective effectiveness are highlighted including when and if a delay in the fuel cut-off will be effective. An example of a Case study with actual field data of a high pressure ratio centrifugal compressor employed in a natural gas compressor station is presented to illustrate the fundamental concept of single vs. dual recycle systems.
Using Semantics for News Navigation (2008)

We present a system for browsing news that is based on semantic similarity of documents. News documents get automatically annotated semantically using information extraction. Annotations are displayed to a user who can easily retrieve crosslingual semantically related documents by selecting interesting items.
A 350-MS/s Continuous-Time Delta–Sigma Modulator With a Digitally Assisted Binary-DAC and a 5-Bits Two-Step-ADC Quantizer in 130-nm CMOS (2014)

Two techniques to improve the performance of continuous-time delta-sigma (CTDS) modulators are presented. A digital calibration technique is introduced to enable the use of binary current digital-to-analog converters (DACs) without dynamic element matching. Furthermore, a high-speed two-step analog-to-digital data converter quantizer is introduced to efficiently increase the resolution of the quantizer in CTDS modulators with high-sampling rates. A proof-of-concept prototype implemented in 130-nm CMOS shows that the proposed calibration technique can compensate for up to 5% of mismatch in the DAC elements. The modulator has a measured SNDR/SFDR of 60.3/74 dB for a sampling rate of 350 MS/s and oversampling ratio of 20, translating to an 8.75-MHz bandwidth. The total power consumption is 5.5 mW from a 1.6 V supply.
Possibility of High-Temperature Evaluation of Phase Coherent Length of Hot Electrons in Triple-Barrier Resonant Tunneling Diodes (1995)

To investigate the possibility of estimating hot electron phase coherence at high temperature, the current-voltage ( I - V ) characteristic of a triple-barrier resonant tunneling diode (TBRTD) is analyzed taking phase breaking into account. When the central barrier width is larger than 7 nm in GaInAs/InP TBRTD, the width of the peak in the I - V curve is determined predominantly by the phase breaking. Therefore the peak width provides the information of the phase coherent length of the hot electrons. It is shown that the phase coherent length can be estimated up to 100 K using TBRTD.
Automatic speaker age and gender recognition in the car for tailoring dialog and mobile services (2010)

Car manufacturers are faced with a new challenge. While a new generation of “digital natives” becomes a new customer group, the problem of aging society is still increasing. This emphasizes the need of providing flexible in-car dialog that take into account the specific needs and preferences of the respective user (group). Along the lines of this year’s Interspeech motto “Spoken Language Processing for All”, we address the question how we find out which group the current user belongs to. We present a GMM/SVM-supervector system (Gaussian Mixture Model combined with Support Vector Machine) for speaker age and gender recognition, a technique that is adopted from state-of-the-art speaker recognition research. We furthermore describe an experimental study with the aim to evaluate the performance of the system as well as to explore the selection of parameters.
Modélisation thermique du soudage hybride par frottement malaxage assisté laser (poster) (2008)

National audience
Space Frequency-Comb for In-Orbit-Demonstration in Low-Earth-Orbit (2022)

We present a compact, radiation tolerant, space frequency comb that is scheduled for an in-orbit-demonstration in low-earth-orbit with a launch in 2024.
SPATIAL HETEROGENEITY AND INSECT ADAPTATION TO TOXINS (1998)

Behavioral responses of insect herbivores to toxins are examined in managed and natural systems with reference to two important but largely ignored factors: heterogeneity in toxin distributions and the nature of the relationship between behavioral responses and physiological adaptation to the same toxins. Heterogeneous toxin distributions, which provide the opportunity for behavioral responses, are ubiquitous in managed and natural systems. Insect herbivores have evolved a wide variety of behavioral responses to such toxins. The nature of behavioral responses reflects toxin apparency, mode of action, and the extent to which sublethal effects influence behavior. The interaction between these behavioral responses to heterogeneously distributed toxins and physiological mechanisms of tolerance has influenced the evolution of insecticide resistance in managed systems and the evolution of plant defensive strategies in natural systems. An understanding of this interaction could lead to more evolutionarily stable methods of crop protection.
Elliptic Curve Cryptography: The Serpentine Course of a Paradigm Shift. (2008)

Abstract. Over a period of sixteen years elliptic curve cryptography went from being an approach that many people mistrusted or misunderstood to being a public key technology that enjoys almost unquestioned acceptance. We describe the sometimes surprising twists and turns in this paradigm shift, and compare this story with the commonly accepted Ideal Model of how research and development function in cryptography. We also discuss to what extent the ideas in the literature on “social construction of technology ” can contribute to a better understanding of this history. 1.
Seamless assembly of DNA parts into functional devices and higher order multi-device systems (2019)

A new method is introduced allowing seamless assembly of independent, functionally tested, blunt-end double strand nucleic acid parts (DNA fragments not supplied in vectors such as plasmids) into more complex biological devices (e.g. protein expression vectors) and higher order multi-device systems (e.g. biochemical pathways). Individual parts include bacterial selection markers and origins of replication, promoters useful in a variety of species, transcription terminators, shuttle sequences and a variety of "N" and "C" terminal solubility/affinity protein tags. Parts are not subjected to pre-assembly manipulation with nucleic acid modifying enzymes. Instead, they are simply mixed in appropriate pre-defined combinations and concentrations and then seamlessly linked into devices employing a specialized thermostable enzyme blend. Combinatorial assembly of parts is an inherent time-saving feature of the new method, in contrast to hierarchical binary assembly ("one part at a time") methods. This feature substantially simplifies and speeds optimization of device and system development. The versatility and functionality of the new method was shown by combinatorial assembly of parts into vector devices, one of which optimally expressed protein from a model gene. Also, a four-enzyme biosynthetic pathway system was re-created by combinatorial construction from parts and devices. Concepts discussed in this paper provide synthetic biologists, chemists and bio-engineers with improved and expanded capability to create novel biological molecules and systems.
Intensification of Flow Characteristics in a Laminar Flow Stirred Tank Using Modified Impeller Designs (2010)

In this experimental study, the effect of a modified 4-alternating pitched blade turbine (4-APBT) on isolated mixing regions (IMRs) was studied using a Newtonian fluid at low Reynolds numbers. The dimensionless mixing time, Ntm, was measured using direct visualization of an acid–base reaction within the Newtonian fluid. The digital image analysis of the photographs revealed that the use of 4-APBT leads to smaller IMR structure volumes (less than 20% of total liquid volume) and reduced mixing time by 60% compared to those obtained with the 4-blade disc turbine (4-DT).
HUMAN PLATELETS ACTIVATE PORCINE ENDOTHELIAL CELLS THROUGH A CD154 DEPENDENT MECHANISM. (2000)

Xu, He1; Arnaud, Francoise1; Tadaki, Douglas K.1; Burkly, Linda C.2; Harlan, David M.1; Kirk, Allan D.1 Author Information