gebhart/patrepeval huggingface dataset:
In Memoriam, Azriel Rosenfeld (1931-2004) (2004)

A brief biography of Azriel Rosenfeld (1931-2004) is given highlighting his professional achievements. Dr. Rosenfeld was widely regarded as the leading researcher in the world in the field of computer image analysis.
Aceleração de Assinaturas Baseadas em Atributos para Internet das Coisas (2019)

Antes de integrar dispositivos com restrições de recursos computacionais em domínios de IoT, deve-se garantir que possuam ferramental criptográﬁco suﬁciente para estabelecer mecanismos de segurança essenciais. Neste contexto, as Assinaturas baseadas em Atributos (ABS) mostramse uma opção elegante na implementação de um esquema de autenticação e autorização. Neste trabalho discutimos diferentes abordagens para a aceleração de (ABS) considerando-se como plataforma alvo os dispositivos com restrições de recursos computacionais em domínios de IoT.
The Activation of Metabolites of Nitric Oxide Synthase by Metals Is Both Redox and Oxygen Dependent: A New Feature of Nitrogen Oxide Signaling (2006)

Nitrite (NO(2)-), N (G)-hydroxy-L-arginine (NOHA), and hydroxylamine (NH(2)OH) are products of nitric oxide synthase (NOS) activity and can also be formed by secondary reactions of nitric oxide (NO). These compounds are commonly considered to be rather stable and as such to be dosimeters of NO biosynthesis. However, each can be converted via metal-catalyzed reactions into either NO or other reactive nitrogen oxide species (RNOS), such as nitrogen dioxide (NO(2)) and nitroxyl (HNO), which have biologic activities distinct from those of the parent molecules. Consequently, certain aspects of tissue regulation controlled by RNOS may be dictated to a significant extent by metal-dependent reactions, thereby offering unique advantages for cellular and tissue regulation. For instance, because many metal-catalyzed reactions depend on the redox and oxygen status of the cellular environment, such reactions could serve as redox indicators. Formation of RNOS by metal-mediated pathways would confine the chemistry of these species to specific cellular sites. Additionally, such mechanisms would be independent both of NO and NOS, thus increasing the lifetime of RNOS that react with NO. Thus metal-mediated conversion of nitrite, NOHA, and NH(2)OH into biologically active agents may provide a unique signaling mechanism. In this review, we discuss the biochemistry of such reactions in the context of their pharmacologic and biologic implications.
Millimeter-resolution optical time-domain reflectometry using a four-wave mixing sampling gate (1995)

We report an optical time-domain reflectometer that employs an ultrafast optical switch based on nondegenerate four-wave mixing in a semiconductor laser amplifier. Two-point spatial resolution on the order of 1 mm over 2 m is demonstrated; Fresnel reflections with optical return losses greater than 53 dB are detected. Submillimeter-resolution optical time-domain reflectometry over a 100-m range should be possible with modifications to the pulse sources.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Quality of red blood cells washed using the ACP 215 cell processor: assessment of optimal pre‐ and postwash storage times and conditions (2013)

Based on all acceptance criteria, a maximum 14-day prewash storage period and 7-day postwash storage period in SAGM preservative was found to be optimal. The longer outdate time postwashing should help lessen challenges in providing components to patients before expiry.
Medical and Dental Electronic Health Record Reporting Discrepancies in Integrated Patient Care (2019)

Our study illustrates an urgent need for policy innovation within a currently fragmented health care delivery system. Dental clinicians rely on the accuracy of health information provided by patients, which we found was misreported in ~15% to 30% of dental patient records. An integrated health care system can close these misreporting gaps. Policies that support the integration of medical and dental records can improve the quality of health care delivered, particularly for dental patients with underlying medical conditions.
Project Hubble: Multi-User XR Collaboration Tool (2022)

The work introduces Project Hubble, Unity's internal multi-user XR collaboration tool.
Nanoparticle Technology for Biorefining of Non-Food Source Feedstocks (2013)

The goal of this proposed work is to develop and optimize the synthesis of mesoporous nanoparticle materials that are able to selectively sequester fatty acids from hexane extracts from algae, and to catalyze their transformation, as well as waste oils, into biodiesel. The project involves studies of the interactions between the functionalized MSN surface and the sequestering molecules. We investigate the mechanisms of selective extraction of fatty acids and conversion of triglycerides and fatty acids into biodiesel by the produced nanoparticles. This knowledge is used to further improve the properties of the mesoporous nanoparticle materials for both tasks. Furthermore, we investigate the strategies for scaling the synthesis of the catalytic nanomaterials up from the current pilot plant scale to industrial level, such that the biodiesel obtained with this technology can successfully compete with food crop-based biodiesel and petroleum diesel.
Abstract B62: Potent single agent in vivo activity of the PARP inhibitor veliparib (ABT-888) in BRCA-deficient xenografts (MX-1 and Capan-1). (2011)

Abstract PARP's role in DNA damage recognition/repair makes PARP inhibition an attractive cancer therapeutic target. Veliparib (ABT-888) is a potent PARP inhibitor with excellent oral bioavailability that readily crosses the blood-brain barrier and is currently in Phase 2 clinical trials. Veliparib has shown significant ability to potentiate multiple DNA damaging agents (cisplatin, carboplatin, cyclophosphamide, irinotecan, radiation and temozolomide) in a spectrum of tumors from multiple histological types. In studies using cytotoxic combinations with veliparib (cisplatin, cyclophosphamide, TMZ) there was a marked increase in efficacy over cytotoxic monotherapies, especially in the MX-1 breast model. Since DNA repair deficiencies (e.g. HR-defective) are known to render cells very sensitive to PARP inhibition, we genotyped the MX-1 breast line and found it to be HR-deficient. Subsequent studies with both the MX-1 (BRCA1-deleted and BRCA2-mutated breast line) and the Capan-1 (BRCA2-deficient pancreatic cancer cell line), showed that veliparib (25 mg/kg/day, p.o., b.i.d.×5) demonstrated enhancement of TMZ (50 mg/kg/day, p.o., q.d.×5) activity, with regressions compared to TMZ alone (81–97% TGI, tumor growth inhibition). Continuous dosing at 4×-8× higher doses (100 and 200 mg/kg/day, p.o., b.i.d.×21) demonstrated a significant single agent, dose-responsive activity (26–87% TGI). Similar results were observed with single agent veliparib treatment of BRCA isogenic cell lines in vitro. Further, the combination treatment of veliparib (100 and 200 mg/kg/day, p.o., b.i.d.×21) with carboplatin, carbotaxol, radiation, gemcar, cyclophosphamide, topotecan and TMZ also demonstrated a measurable advantage over either veliparib or cytotoxic agent alone. Both high dose single agent veliparib and the cytotoxic combination therapy were well tolerated and there were no observable animal health concerns; this indicated the feasibility of using the single agent and cytotoxic combination regimen in the clinic. Analysis of tumors for the reduction of PAR after veliparib treatment demonstrated a correlative and significant reduction by western blot indicating the ability of veliparib to inhibit PARP activity in vivo. Altogether, our studies show the strong activity of veliparib as a single agent in BRCA-deficient xenografts as well as the enhanced activity and tolerability of veliparib in combination with various cytotoxic agents. These results warrant investigation of single agent therapy and cytotoxic combination regimens in BRCA-deficient patients to further the clinical development of veliparib. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2011 Nov 12-16; San Francisco, CA. Philadelphia (PA): AACR; Mol Cancer Ther 2011;10(11 Suppl):Abstract nr B62.
Subclinical Contrast-Induced Acute Kidney Injury in Patients Undergoing Cerebral Computed Tomography (2020)

This study showed that intra-arterial modern contrast media administration may have a nephrotoxic effect in a population without pre-existing chronic kidney disease. Further investigations on larger scale are warranted to confirm if Iopamidol exposed patients to increased risk of SCI-AKI compared to Iodixanol.
Lentiviral Vectors as a Vaccine Platform against Infectious Diseases (2023)

Lentiviral vectors are among the most effective viral vectors for vaccination. In clear contrast to the reference adenoviral vectors, lentiviral vectors have a high potential for transducing dendritic cells in vivo. Within these cells, which are the most efficient at activating naive T cells, lentiviral vectors induce endogenous expression of transgenic antigens that directly access antigen presentation pathways without the need for external antigen capture or cross-presentation. Lentiviral vectors induce strong, robust, and long-lasting humoral, CD8<sup>+</sup> T-cell immunity and effective protection against several infectious diseases. There is no pre-existing immunity to lentiviral vectors in the human population and the very low pro-inflammatory properties of these vectors pave the way for their use in mucosal vaccination. In this review, we have mainly summarized the immunological aspects of lentiviral vectors, their recent optimization to induce CD4<sup>+</sup> T cells, and our recent data on lentiviral vector-based vaccination in preclinical models, including prophylaxis against flaviviruses, SARS-CoV-2, and <i>Mycobacterium tuberculosis</i>.
Local Monitoring of the Internet Network (2003)

The internet, as well as other freely evolving networks, has a topology that changes dynamically; therefore the topology is very complicated. Presently, there is an increase in dependency on the internet for several things such as communication, information traffic and many more, hence it is imperative that we prevent attackers from disrupting this network. To do this, it is essential to count on a mathematical model that can allow early detection (then ring the bell) of attacks to the network. The mathematical tool that we are looking for to accomplish that early detection is based on the use of Tomography ideas. The last statement is based on the April 28-29, 2000 workshop on the inter-face between the mathematical sciences and three areas of computer science:network traffic modeling, computer vision, and data mining and search. Thisworkshop was cosponsored by the Board on Mathematical Sciences andthe Computer Science and Telecommunications Board of the National ResearchCouncil.
Non-Invasive Experimental Identification of a Single Particle Model for LiFePO4 Cells (2023)

The rapid spread of Lithium-ions batteries (LiBs) for electric vehicles calls for the development of accurate physical models for Battery Management Systems (BMSs). In this work, the electrochemical Single Particle Model (SPM) for a high-power LiFePO4 cell is experimentally identified through a set of non-invasive tests (based on voltage-current measurements only). The SPM is identified through a two-step procedure in which the equilibrium potentials and the kinetics parameters are characterized sequentially. The proposed identification procedure is specifically tuned for LiFePO4 chemistry, which is particularly challenging to model due to the non-linearity of its open circuit voltage (OCV) characteristic. The identified SPM is compared with a second-order Equivalent Circuit Model (ECM) with State of Charge dependency. Models performance is compared on dynamic current profiles. They exhibit similar performance when discharge currents peak up to 1C (RMSE between simulation and measures smaller than 20 mV) while, increasing the discharge peaks up to 3C, ECM's performance significantly deteriorates while SPM maintains acceptable RMSE (&lt; 50 mV).
Supplementary Data from The Discovery and Preclinical Development of ASG-5ME, an Antibody–Drug Conjugate Targeting SLC44A4-Positive Epithelial Tumors Including Pancreatic and Prostate Cancer (2023)

&lt;p&gt;Figure S1. Proteolytic release of MMAE from ASG-5ME; Figure S2. SLC44A4 RNA expression in normal and tumor specimens from combined Oncomine data sets; Figure S3: Expression of SLC44A4 in OVCAR-5 cells determined by FACS.&lt;/p&gt;
<title>Noise reduction performance of smart panels incorporating piezoelectric shunt damping</title> (2002)

Performance test for transmitted noise reduction of smart panels is experimentally studied. Smart panel is a panel that is utilized a passive material at high frequencies and piezoelectric shunt damping at low frequencies. A multi-mode shunt damping is investigated by using the tuning method based on measured electrical impedance. Three configurations of smart panels are tested: single panel, single panel with sound absorbing material and double panel. The single panel consists of a host plate structure on which four piezoelectric patches are bonded and electrical shunt circuits are connected independently. The parameters for resonant shunt are determined by maximizing the dissipated energy through the circuit. The transmitted noise reduction performance of smart panels is tested in an acoustic tunnel. Sound absorbing material and air gap reduces the sound transmitted at the mid-frequency region effectively while the use of piezoelectric shunt damping can work at resonance frequencies of the panel structure. As a result, a remarkable noise reduction of 15dB was achieved in a wide band frequency region. The double panel exhibits better noise reduction than other panels. This approach was also applied to the structural acoustic problem of turbulent boundary layer (TBL) induced sound radiated from a panel, and results are discussed.
Synthesis and Evaluation of New Intramolecular Cure Intermediates. (1982)

Abstract : The objectives of this research were the synthesis of 1,4,4,7-tetraphenyl-hepta-1,6-diyne-3,5-dione, 1,3,4,6-tetraphenylhexa-3-ene-1,5-diyne, 3-amino-2-(m-aminophenylethynyl)-N-phenylbenzamide and 4-amino-2-(m-aminophenylethynyl)-N-phenylbenzamide and their evaluation as potential intramolecular cure (IMC) agents. The reaction of diphenylmalonyl dichloride with phenylacetylene in the presence of bis(triphenylphosphine)palladium(II)dichloride yields diphenylbutadiyne as the major product. The reaction of similarly substituted malonyl dichlorides with cuprous phenylacetylide yields only diphenylbutadiyne. The reaction of phenylethynylmagnesium bromide with substituted malonaldehydes followed by oxidation of the resulting diol to a diketone represents a better synthetic method if the malonaldehydes are available.
Iron Treatment in Children with Attention Deficit Hyperactivity Disorder (1997)

Iron plays a role in the regulation of dopaminergic activity. In the present study, nonanemic children with attention deficit hyperactivity disorder (ADHD) were evaluated with regard to heme and nonheme iron metabolism and the effect of short-term iron administration on behavior. The study group consisted of 14 boys aged 7-11 years. All first underwent testing to rule out other psychiatric and medical problems. The severity of the ADHD symptoms was determined by parent and teacher scores on the Connors Rating Scale. Thereafter, each patient received an iron preparation (Ferrocal), 5 mg/kg/day for 30 days. Blood samples were taken before and after drug administration. Results showed a significant increase in serum ferritin levels (from 25.9 +/- 9.2 to 44.6 +/- 18 ng/ml) and a significant decrease on the parents' Connors Rating Scale scores (from 17.6 +/- 4.5 to 12.7 +/- 5.4). There were no changes in other blood parameters or in the teachers' scores on the rating scale. The effect of iron supplementation on the behavioral and cognitive symptoms in noniron-deficient ADHD children merits further investigation using a placebo-controlled study.
Field Demonstration of Surface Human-Robotic Exploration Activity. (2006)

We demonstrated integrated technology for multiple crew and robots to work together in a planetary surface exploration scenario. Highlights include dynamic replanning, “many to many ” rover commanding, efficient human-system interaction and workflows, single cycle instrument placement, and data management.
Design Considerations for High Pressure Turbo Expanders Supported by Active Magnetic Bearings (2019)

Abstract Nowadays industrial processes are going toward high power density solutions. This can be read as a general increase in pressure (more than 200 barA) and fluid density indicating Turbo Expander (TEX) as a worthwhile solution to boost main process compressors and increasing process efficiency. On the other hand, inlet high pressure and high density fluids could lead to strong pressure pulsations on the impeller with consequences on the rotordynamic behavior, rotor stability and bearing integrity. For this purpose, a full annulus unsteady CFD analysis of the flow path through the inlet plenum, nozzles and impeller has been performed and analyzed in terms of resulting force FFT on the impeller. The force signal is used as an input of the rotor model supported by Active magnetic bearings (AMB), including their control system and transfer function. The aim of the study is the investigation of the influence of high density gas in TEX applications, coupling the results of unsteady CFD analysis with the dynamic response of the mechanical system. The control system parameters of magnetic bearings are included into the analysis and a sensitivity to different inlet nozzles numbers and inlet pressure levels is performed verifying the feasibility of the rotor.
Transient optical elements: application to near‐field microscopy (2003)

We report methods of near-field infrared microscopy with transient optically induced probes. The first technique - a transient aperture (TA) - uses photoinduced reflectivity in semiconductors to generate a relatively large transient mirror (TM) with a small aperture at its centre. We report the optical properties of the TM and TA and experiments performed on near-field imaging with the TA. The second technique is based on solid immersion microscopy, in which high resolution is achieved when light is focused inside a solid with a high refractive index. By creating a transient Fresnel lens on the surface of a semiconductor wafer via photoinduction, we were able to form a solid immersion lens (SIL) for use as a near-field probe. The use of transient probes eliminates the need for mechanical scanning of the lens or sample, and thus provides a much faster scanning rate and the possibility to work with soft and liquid objects.
Positioning in 5G Networks (2021)

The authors describe the recent 3GPP Release 16 specification for positioning in 5G networks. Release 1 6 specifies positioning signals, measurements, procedures, and architecture to meet requirements in regulatory, commercial, and industrial use cases, extending the positioning capability of the 3GPP standard compared to what was possible with LTE. The indicative positioning performance is evaluated in agreed representative 3GPP simulation scenarios, showing a 90 percentile accuracy of a few meters down to a few decimeters depending on scenarios and assumptions.
Management: Briefs Selection of a Minimum Sample Size for Application of the Regression-Line–Percentile Technique (1996)

Proper application of the relative weight (Wr) index depends on development of a standard weight (Ws) equation for the target species. Development of Ws equations has been facilitated by the regression-line–percentile (RLP) technique, but the minimum data needed to develop a Ws equation with the RLP technique has not been investigated. We applied the bootstrap technique to data sets containing slope values from population log10 weight–log10 total length regressions for nine fish species (50–292 populations each). We randomly selected regression slopes at sequential intervals of five, and each iteration was repeated 100 times to determine the variance about the regression slope means. The sample variance for slopes was observed to decline in an exponential fashion. A minimum level of precision based on the sample variance (<0.002) provided a conservative estimate of necessary sample size (N ≥ 50). This variance benchmark is sufficient for the current level of precision required in the development and application of RLP-generated equations.
Abstract LB-093: Vaccine based immunotherapy regimen (VBIR) for the treatment of prostate cancer (2016)

Abstract A successful cancer vaccine will activate the host immune system to induce a balanced T- and B-cell response to tumor-specific antigens that can lead to tumor regression. Effective cancer vaccines will need to overcome several challenges to accomplish this goal, such as to break tolerance to the tumor associated antigens which are mostly self antigens, induce and maintain high tumor-specific T-cell titers to keep the immune pressure on the tumor as well as to overcome the immune suppressive tumor microenvironment to keep the T-cells active at the tumor site. We have applied the lessons learned in the field to the development of a multi-component cancer immunotherapy regimen that has entered clinical testing at the beginning of 2016 for the treatment of patients with prostate cancer. The vaccine regimen consists of a chimpanzee adenovirus prime vaccination administered intramuscularly followed by DNA boost vaccinations delivered with an electroporation device and with each vaccination low dose of an anti-CTLA4 antibody is administered locally, in close proximity of the vaccine draining lymph nodes. The adenovirus and DNA express the three prostate cancer antigens PSA, PSMA and PSCA. Lastly, sutent or anti-PD-1 is added to the regimen to counter the immune suppressive tumor microenvironment by lowering myeloid derived suppressor cells (by sutent doses that are lower than the approved clinical dose) or interfering with the PD-L1/PD-1 signaling pathway (by anti-PD-1). Data will be presented in tumor-bearing mice and non human primates (NHPs) demonstrating the attributes of the heterologous prime/boost vaccine with local anti-CTLA4 that induces potent, polyclonal and functional tumor-antigen specific T- and B cell responses that are maintained at high levels for up to a year in NHPs. We could also demonstrate that low dose of sutent is highly effective at lowering MDSCs in tumors and the periphery of tumor bearing mice, resulting in significantly enhanced potency of a heterologous prime/boost cancer vaccine. Lastly, our data suggest that - in the context of active vaccination - local delivery of anti-CTLA4 is superior to systemic delivery of the immune modulator at enhancing vaccine induced T-cell responses, thereby broadening the therapeutic window of the immune modulator. Citation Format: Helen Cho, Paul Cockle, Binder Joe, Weeratna Risini, Phil White, Karin Jooss. Vaccine based immunotherapy regimen (VBIR) for the treatment of prostate cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr LB-093.
Decision Tree-based Modelling for Identification of Predictors of Blood Loss and Transfusion Requirement After Adult Spinal Deformity Surgery (2020)

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Tracing the Origin of Food-borne Disease Outbreaks (2020)

Great care should be taken as to whether the underlying network model correctly captures the spreading mechanism of the outbreak in terms of spatial scale and single or multiple source outbreak.