gebhart/patrepeval huggingface dataset:
crude bran extracts and fractions of selected traditional red rice oryza sativa l varieties of sri lanka potentiates anti inflammatory activities in human blood and cell assays (2018)

1. Abstract Crude extracts (70% ethanolic)
and fractions (hexane, dichloromethane, butanol, aqueous ) of brans of four Sri Lankan
traditional red rice varieties <span style=font-size:10.0pt;font-family:
 times= new= roman,serif;color:black;mso-themecolor:text1=>( Oryza
sativa <span style=font-size:
10.0pt;font-family: times= new= roman,serif;color:red=> L. ) <span style=font-size:
10.0pt;font-family: times= new= roman,serif;mso-fareast-font-family:onegullivera;= color:black;mso-themecolor:text1=>, namely, Sudu Heeneti, Goda Heeneti, Masuran
and Dik Wee were studied for a range of anti-inflammatory activities. The
investigated activities included oxidative burst inhibitory activity in human
whole blood, isolated human polymorphonuclear cells and mice peritoneal
macrophages and inhibition of nitric oxide and pro-inflammatory cytokines in cell assays. Further, <span style=font-size:
10.0pt;font-family: times= new= roman,serif;mso-fareast-font-family:onegullivera;= color:black;mso-themecolor:text1=>cytotoxicity <span style=font-size:
10.0pt;font-family: times= new= roman,serif;color:black;mso-themecolor:text1=>was
evaluated against
normal cell line . The <span style=font-size:10.0pt;
font-family: times= new= roman,serif;mso-fareast-font-family:onegullivera;= color:black;mso-themecolor:text1=>results showed for the first time that brans
of all the rice varieties selected for the current study had anti-inflammatory
activities in all the assays tested without inducing cytotoxicity on normal
cells. However, significant differences were observed among different varieties
and between crude extracts and fractions for investigated anti-inflammatory
activities. Partitioning of crude rice bran extracts
showed inhibitory activities in both non-polar and polar fractions. The non-pigmented
dichloromethane fractions exhibited anti-inflammatory activities in all the assays studied. Overall, the properties
observed indicate usefulness of brans of selected Sri Lankan traditional red
rices in the management of inflammation associated chronic diseases.
Indentation stress dependence of the temperature range of microscopic superelastic behavior of nickel-titanium thin films (2005)

The microscopic superelastic behavior of thin-film NiTi is investigated by instrumented indentation experiments conducted at different temperatures. The indentation-induced superelastic effect is found to be persistent to about 100K above the austenite transformation finish temperature (Af). In contrast, the upper temperature where superelastic effect exists is only around Af plus 40K in uniaxial tension and compression tests, beyond which the plasticity of the austenite phase overwhelms the transformation-induced superelasticity. By combining the Clausius-Clapeyron equation and spherical cavity model for indentation, we show that the high hydrostatic pressure under the indenter is capable of elevating the transformation temperatures and increase the upper temperature limit of indentation-induced superelastic behavior.
5G Ultra-Reliable Low-Latency Communication for Factory Automation at Millimetre Wave Bands (2019)

Utilizing the abundant bandwidth in millimeter wave frequency bands is an interesting option to enable wireless communication services with challenging latency and reliability requirements for factory automation. Nevertheless, millimeter wave bands have less favorable propagation properties compared to lower bands, which impacts the coverage negatively. In this paper, we show that millimeter wave bands can fulfill extreme latency and reliability requirements with much higher system capacity than mid-band frequencies by means of beamforming, large antenna arrays, and network densification. This makes millimeter wave bands suitable for providing ultra-reliable low-latency communication services for factory automation. However, we find that small beam misalignments due to channel state information error can degrade the system capacity substantially.
The cluster compiler---a tool for the design of time-triggered real-time systems (1995)

An off-line planning tool that supports the programmer in developing his real-time application is mandatory in the design of time-triggered real-time systems. This paper describes the architecture and the functions of such a tool, the Cluster Compiler, that is in development at our institute. We emphasize on the principle of a strict separation of the local from the global parts of a distributed system and on the consequences for the structure of the design tool arising from this principle.
A Synthesis of Logical and Probabilistic Reasoning for Program Understanding and Debugging (2013)

We describe the integration of logical and uncertain reasoning methods to identify the likely source and location of software problems. To date, software engineers have had few tools for identifying the sources of error in complex software packages. We describe a method for diagnosing software problems through combining logical and uncertain reasoning analyses. Our preliminary results suggest that such methods can be of value in directing the attention of software engineers to paths of an algorithm that have the highest likelihood of harboring a programming error.
In vivo noninvasive monitoring of microhemodynamics using optical-resolution photoacoustic microscopy (2009)

Microvascular autoregulation is an intrinsic ability of vascular beds to compensate for the fluctuation in blood flow and tissue oxygen delivery. This function is crucial to maintaining the local metabolic activity. Here, using optical-resolution photoacoustic microscopy (OR-PAM), we clearly observed vasomotion and vasodilation in the intact mouse microcirculation in vivo in response to the changes in physiological state. Our results show that a significant lowfrequency vasomotion can be seen under hyperoxia but not hypoxia. Moreover, significant vasodilation is observed when the animal status is switched from hyperoxia to hypoxia. Our data show that arterioles have more pronounced vasodilation than venules.
Tumor mutation burden: from comprehensive mutational screening to the clinic (2019)

The recent advent of immunomodulatory therapies into the clinic has demanded the identification of innovative predictive biomarkers to identify patients most likely to respond to immunotherapy and support the design of tailored clinical trials. Current molecular testing for selection of patients with gastrointestinal or pulmonary carcinomas relies on the prevalence of PD-L1 expression in tumor as well as immune cells by immunohistochemistry and/or on the evaluation of the microsatellite status. Tumor Mutational Burden (TMB) has emerged as a promising novel biomarker in this setting to further aid in patient selection. This has been facilitated by the increasing implementation of molecular pathology laboratories with comprehensive next generation sequencing (NGS) technologies. However, the significant overall costs and expertise required for the interpretation of NGS data has limited TMB evaluation in routine diagnostics, so far. This review focuses on the current use of TMB analysis in the clinical setting in the context of immune checkpoint inhibitor therapies.
Point defect geometries in inverted opal photonic crystals (2005)

We study point defect geometries in inverted opal photonic crystals that can be easily fabricated by means of colloidal self-assembly. Two broad classes of defects are considered: substitutional and interstitial. Substitutional point defects are found to introduce a usable defect band into the photonic band gap. This can be done by using a silica sphere of radius between 0.33a and 0.35a (where a is the lattice constant). The state is triply degenerate. Reflectance and local density of states calculations are performed to verify the existence and frequency of this defect. The point defect can be made by precoating shrunk silica spheres with a thin layer of silicon. Such a defect can be used as a microcavity for localizing light at a point, with a quality factor Q that is limited primarily by the proximity of the defect to the surface of the photonic crystal and other such defects.
Structure‐Based Drug Design for G Protein‐Coupled Receptors (2021)

Abstract A transformation in the structural biology of membrane‐associated receptors, particularly of G Protein‐Coupled Receptors (GPCRs), has occurred over the last 10 years and continues to build momentum today. Remarkable new protein–ligand X‐ray crystal and latterly cryo‐EM structures have been published giving a detailed appreciation of how molecules bind to a plethora of fascinating binding sites. The profound impact of these new data on design of ligands for drug discovery, a detailed consideration of the consequences to the computational chemistry community, and a description of some representative applications of Structure‐Based Drug Design (SBDD) are described in this article, with a focus on GPCRs.
Study of the effects of in‐person attendance at academic conferences on the health of the attendees under COVID‐19 pandemic (2023)

Congress attendees who took precautions at the congress to avoid being infected and who had a high vaccination rate did not develop significantly more health problems associated with in-person attendance at the congress.
Recurrence Rate After a First Venous Thrombosis in Patients With Familial Thrombophilia (2005)

Extra care after a first event is required for men with a deficiency in natural anticoagulants or multiple defects and women with antithrombin deficiency.
LaAlO3/SrTiO3-Based Device Concepts (2010)

This is a book chapter that covers several device concepts based on the LaAlO3/SrTiO3 interface.
ChemInform Abstract: Influence of the Structural Parameters of Y Zeolite on the Transalkylation of Alkylaromatics. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
CD45 phosphatase regulates the fate of myeloid cells in tumor microenvironment by inhibiting STAT3 activity (2016)

Abstract The abnormal differentiation of myeloid cells is one of the key features of altered immune response in cancer. Myeloid derived suppressor cells (MDSC) and tumor associated macrophages (TAM) are the major components of immune suppressive network. MDSC accumulate in large numbers in peripheral lymphoid organs and inside tumors. However, in contrast to peripheral lymphoid organs such as spleen, inside tumors, monocytic MDSC rapidly differentiate to TAM with potent immune suppressive activity. We have demonstrated that this phenomenon is mediated by dramatic down-regulation of STAT3 activity in MDSC in tumor site. In cancer patients, MDSC in tumor site also had substantially lower level of pSTAT3 than MDSC in peripheral blood. These results were unexpected, since high level of STAT3 activity is a hallmark of MDSC present in blood and lymphoid organs. The mice with constitutively active STAT3 had shown the expansion of MDSC and down-regulation of macrophage population in tumor microenvironment, emphasizing the crucial role of STAT3 in myeloid cell differentiation. Hypoxia is an intricate part of tumor microenvironment. The decreased STAT3 activity was caused by hypoxia and affected all myeloid cells but was not observed in tumor cells. We further demonstrate that the up-regulation of CD45 tyrosine phosphatase activity in MDSC exposed to hypoxia in tumor site was responsible for down-regulation of STAT3 activity. Moreover, the positive regulation of CD45 activity in hypoxia was mediated by the disruption of CD45 protein dimerization via sialylation. This suggests a novel role of STAT3 in the regulation of myeloid cells in tumors with potential implications for therapeutic targeting.
Supplemental Table 1 from Identification of Anti-CA125 Antibody Responses in Ovarian Cancer Patients by a Novel Deep Sequence–Coupled Biopanning Platform (2023)

&lt;p&gt;Supplemental Table 1. Top 25 ranked peptides from Round 2 of selection with OvCa patient IgG.&lt;/p&gt;
Methyl 3,4,6-tri-O-acetyl-2-deoxy-2-azido-α-D-galactopyranosyl-(1→2)-[3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl-(1→3)]-4-O-benzoyl-α-L-rhamnopyranosiden-hexane 0.1-solvate (2007)

The title compound, C51H56N4O21·0.1C6H14, crystallizes with two independent protected tris­accharide mol­ecules and a partially occupied hexane solvent mol­ecule in the asymmetric unit. The major conformational difference between the two tris­accharide mol­ecules involves the O-acetyl group at the exocyclic primary C atom of the galactosyl residue.
Distributed clustering and interference management in two-tier networks (2012)

Employing centralized resource management schemes is generally infeasible in large-scale networks. The deployment of heterogeneous Femtocell Access Points (FAPs) over the cellular licensed spectrum is therefore challenging. In particular, the resulting inter-node interference inhibits the network performance. In this paper, we design a hierarchical, distributed, interference management scheme that exploits the benefits of clustering. First, in order to reduce the cross-tier interference, each FAP independently identifies vacant subbands for potential transmission. Then, by exchanging some simple messages with its immediate neighbors in an iterative fashion, coalition clusters are formed. Given the small population of each group, centralized resource management is subsequently performed to avoid intra-cluster interference. Different clusters, however, may still share a fraction of common idle channels, which degrades system performance. Therefore, this paper further considers inter-cluster interference management to determine the set of privileged FAPs that can share a subband via solving a binary power control optimization problem. While the optimal solution requires prohibitive complexity, this paper provides tight bounds on the sum rate of the binary power control problem. The simulation results show that, in a high interference regime, inter-cluster coordination provides a significant performance improvement compared to the case of no coordination.
Multi-Stream Spatial Digital Predistortion for Fully-Connected Hybrid Beamforming Massive MIMO Transmitters (2021)

In this paper, a novel multi-stream spatial digital predistortion (DPD) technique is proposed to model and linearize the fully-connected (FC) hybrid beamforming (HBF) transmitters. The proposed scheme solves the DPD implementation issue in the FC HBF array by estimating and linearizing the beam signals instead of the individual PAs. In FC HBF systems, significant intermodulation (IMD) between different transmit signals will be generated due to the analog beamforming and combining network upstream of the power amplifiers (PAs). The IMD beams will end up being radiated in different directions and some of them might fall in the linear beam directions. Therefore, multi-input DPD blocks using a practical multi-variable model are constructed for each RF chain to eliminate the complicated inner- and cross-channel IMDs of the beam signals. Simulations on a 4-stream 64-element FC HBF array and experimental tests on a 2-stream 4-element system are carried out to benchmark the proposed DPD technique against the conventional techniques. Better than 13 dB adjacent channel power ratio (ACPR) improvement and 12 dB normalized mean square error (NMSE) improvement have been achieved by the proposed DPD technique.
Resolution-Enhanced Kendrick Mass Defect Analysis of Polycyclic Aromatic Hydrocarbons and Fullerenes in the Diffusion Flame from a Butane Torch (2018)

A modified Kendrick Mass Defect (KMD) analysis was applied to the analysis of polycyclic aromatic hydrocarbons (PAHs) and fullerenes in the diffusion flame from a handheld butane torch. Graphical Abstract ᅟ.
<title>Interferometric technique for the concurrent determination of thermo-optic and thermal expansion coefficients</title> (1991)

An interferometric technique is described that uses a Fabry-Perot type configuration to measure the coefficient of thermal expansion (CTE) and the thermo-optic coefficient (dn/dT) of transparent materials concurrently. A number of measurements of the CFE and dn/dT are made for both oxide and fluoride based glasses. These measurements show that the technique is accurate, reproducible, and is very effective in determining the temperature dependence of both the thermo-optic and thermal expansion coefficients.
31P NMR spectroscopy of the in vivo metabolism of an intracerebral glioma in the rat (1988)

The in vivo high-energy phosphorus metabolic profile and pH of an experimental intracerebral C6 glioma in rats was examined using surface coil 31P NMR spectroscopy. Initially, phosphorus-containing metabolites of the glioma were characterized by in vivo 31P surface coil spectroscopy of subcutaneously implanted tumors and by high-resolution NMR studies of perchloric acid (PCA) extracts of both freeze-clamped subcutaneous tumor tissue and cultured cells. These studies demonstrated that the C6 glioma has reduced levels of phosphocreatine (PCr) compared to the levels found in normal rat brain. Thus, reduced spectral PCr levels were useful as a metabolic indicator for monitoring the spatial selectivity of tumor metabolism distinct from that of adjacent normal brain tissue. To maximize 31P NMR signals from intracerebral tumors, tumor cells were stereotaxically placed superficially in the brain. Proton magnetic resonance imaging (1H MRI) was used to determine the size and location of the resultant brain tumors in order to preselect rats with large superficial tumors for spectroscopic study. 31P NMR spectra of the glioma tumors revealed a consistent reduction in the PCr/ATP ratio, an increase in the Pi/ATP ratio, and a slightly increased tissue pH. No correlation was found between levels of Pi/ATP and tumor pH in subcutaneous or intracerebral gliomas and the amount of necrosis as determined histologically. This study demonstrates that phosphorus metabolites of an experimental brain tumor in the rat can be monitored in vivo with minimal contributions from adjacent normal brain tissue metabolites using surface coil 31P NMR spectroscopy.
A total ordering on languages with a bipartite alphabet (2002)

We consider the Ramadge-Wonham framework for discrete event (dynamical) systems. Therein arise situations when the supervisory marking problem or the supervisory control problem is not solvable and hence, a unique minimally restrictive language does not exist. In such cases, a basis is needed for language comparison to select an appropriate alternative. We consider the case of prefix-closed regular languages containing "illegal" strings. Languages are naturally partially ordered by inclusion. The aim here is to define a measure for these languages based upon the nature of "illegal:" strings they contain. The measure should impose a total ordering on such languages and thus enable selection of better controllers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Partial purification of the epidermal G2 chalone based on an in vivo assay system (1981)

The epidermal G2 chalone was partially purified from hairless mouse skin extracts by means of chromatography and ultrafiltration and tested in vivo on hairless mouse epidermis. The active component had a molecular weight of less than 10,000 daltons. It significantly but had no effect on epidermal cells at the G1/S transition. Extracts from mouse spleen or skeletal muscle treated in the same way as the skin extracts had no inhibitory effect on epidermal G2 cells.
Cell Wall Damage-Induced Lignin Biosynthesis Is Regulated by a Reactive Oxygen Species- and Jasmonic Acid-Dependent Process in Arabidopsis (2011)

The plant cell wall is a dynamic and complex structure whose functional integrity is constantly being monitored and maintained during development and interactions with the environment. In response to cell wall damage (CWD), putatively compensatory responses, such as lignin production, are initiated. In this context, lignin deposition could reinforce the cell wall to maintain functional integrity. Lignin is important for the plant's response to environmental stress, for reinforcement during secondary cell wall formation, and for long-distance water transport. Here, we identify two stages and several components of a genetic network that regulate CWD-induced lignin production in Arabidopsis (Arabidopsis thaliana). During the early stage, calcium and diphenyleneiodonium-sensitive reactive oxygen species (ROS) production are required to induce a secondary ROS burst and jasmonic acid (JA) accumulation. During the second stage, ROS derived from the NADPH oxidase RESPIRATORY BURST OXIDASE HOMOLOG D and JA-isoleucine generated by JASMONIC ACID RESISTANT1, form a negative feedback loop that can repress each other's production. This feedback loop in turn seems to influence lignin accumulation. Our results characterize a genetic network enabling plants to regulate lignin biosynthesis in response to CWD through dynamic interactions between JA and ROS.
A DC to 110 GHz Plasma Switch (2022)

This paper demonstrates the first optically-controlled, solid-state-plasma switch from DC-110 GHz. We investigate both a single fiber and a two-fiber π-switch on a coplanar-waveguide (CPW) technology. The switch is activated when a 915-nm optical source generates active carriers in the CPW gaps. Measured results show that for the single fiber case, insertion loss is better than 0.22 dB and isolation is greater than 42 dB at 110 GHz. Further, for the two-fiber, π-match case, insertion loss is better than 0.81 dB and isolation greater than 53 dB at 110 GHz. However, the two-fiber design exhibits higher than 40 dB isolation across the entire 20–110 GHz band. The presented switch is the first demonstration of this wideband nerformance with low insertion loss and high isolation.
Author Correction: Global karst springs hydrograph dataset for research and management of the world’s fastest-flowing groundwater (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Explicit model predictive control of buck converter (2012)

This article proposes a model predictive control (MPC) design to control a fixed frequency DC-DC power converter in a defined operating domain. The prediction model used for the control synthesis is a piecewise affine approximation (PWA) that covers the whole operating range of the converter. Based on the obtained hybrid model a constrained optimal control problem is formulated and solved. The explicit form of the control law is derived offline as an affine state feedback controller. This explicit controller is stored in a look-up table for implementation. The experimental results show the potential advantages of this control approach in comparison with a static state-feedback or a classic PI controller.