gebhart/patrepeval huggingface dataset:
Resatorvid‐based Pharmacological Antagonism of Cutaneous TLR4 Blocks UV‐induced NF‐κB and AP‐1 Signaling in Keratinocytes and Mouse Skin (2016)

Cutaneous exposure to solar ultraviolet (UV) radiation is a major causative factor in skin carcinogenesis, and improved molecular strategies for efficacious chemoprevention of nonmelanoma skin cancer (NMSC) are urgently needed. Toll-like receptor 4 (TLR4) signaling has been shown to drive skin inflammation, photoimmunosuppression, and chemical carcinogenesis. Here we have examined the feasibility of genetic and pharmacological antagonism targeting cutaneous TLR4 for the suppression of UV-induced NF-κB and AP-1 signaling in keratinocytes and mouse skin. Using immunohistochemical and proteomic microarray analysis of human skin, we demonstrate for the first time that a significant increase in expression of TLR4 occurs in keratinocytes during the progression from normal skin to actinic keratosis, also detectible during further progression to squamous cell carcinoma. Next, we demonstrate that siRNA-based genetic TLR4 inhibition blocks UV-induced stress signaling in cultured keratinocytes. Importantly, we observed that resatorvid (TAK-242), a molecularly targeted clinical TLR4 antagonist, blocks UV-induced NF-κB and MAP kinase/AP-1 activity and cytokine expression (Il-6, Il-8, and Il-10) in cultured keratinocytes and in topically treated murine skin. Taken together, our data reveal that pharmacological TLR4 antagonism can suppress UV-induced cutaneous signaling, and future experiments will explore the potential of TLR4-directed strategies for prevention of NMSC.
Noisy FitzHugh-Nagumo model: From single elements to globally coupled networks (2004)

We study the noisy FitzHugh-Nagumo model, representative of the dynamics of excitable neural elements, and derive a Fokker-Planck equation for both a single element and for a network of globally coupled elements. We introduce an efficient way to numerically solve this Fokker-Planck equation, especially for large noise levels. We show that, contrary to the single element, the network can undergo a Hopf bifurcation as the coupling strength is increased. Furthermore, we show that an external sinusoidal driving force leads to a classical resonance when its frequency matches the underlying system frequency. This resonance is also investigated analytically by exploiting the different time scales in the problem.
Learning to Rearrange with Physics-Inspired Risk Awareness (2022)

Real-world applications require a robot operating in the physical world with awareness of potential risks besides accomplishing the task. A large part of risky behaviors arises from interacting with objects in ignorance of affordance. To prevent the agent from making unsafe decisions, we propose to train a robotic agent by reinforcement learning to execute tasks with an awareness of physical properties such as mass and friction in an indoor environment. We achieve this through a novel physics-inspired reward function that encourages the agent to learn a policy discerning different masses and friction coefficients. We introduce two novel and challenging indoor rearrangement tasks -- the variable friction pushing task and the variable mass pushing task -- that allow evaluation of the learned policies in trading off performance and physics-inspired risk. Our results demonstrate that by equipping with the proposed reward, the agent is able to learn policies choosing the pushing targets or goal-reaching trajectories with minimum physical cost, which can be further utilized as a precaution to constrain the agent's behavior in a safety-critic environment.
Carbon monolith scaffolding for high volumetric capacity silicon Li-ion battery anodes (2017)

A nanoporous carbon monolith structure has been developed for use as a scaffold for silicon anodes for lithium batteries. This scaffold was fabricated by coating vertically aligned carbon nanotubes in a highly conformal coating of nanocrystalline carbon, applied via atmospheric pressure chemical vapor deposition. The coating increases the mechanical stability of the nanotube structure, which provides electrically conductive pathways through the anode. Silicon anodes were fabricated with the monoliths by low pressure chemical vapor infiltration of silicon. This platform allows the carbon and silicon volume fractions to be independently varied in the anode. Anodes with a low silicon content (less than 5% by volume) showed high stability in cycling against lithium with a capacity retention of 89.7% between cycles 2 and 185. Anodes with a high silicon content (∼25% by volume) showed poor capacity retention when the carbon content was low (&amp;lt;40% by volume), and transmission electron microscopy analysis indicated that the anodes failed due to the destruction of the nanocrystalline carbon coating during cycling. However, by increasing the carbon content to ∼60% volume percent in the monolith, capacity retention was substantially stabilized even for anodes with very high silicon loadings. These stabilized electrodes exhibited volumetric capacities as high as ∼1000 mA h/ml and retained over 725 mA h/ml by cycle 100.
Carbon Coating for Improvements of Electrochemical Properties of Li<sub>1.1</sub>V<sub>0.9</sub>O<sub>2</sub> Anode Active Materials for Li Secondary Batteries (2019)

Generally, Lithium Vanadium Oxide has a larger volumetric capacity anode active material than that of graphite. Unfortunately, LVO (Li1.1V0.9O2) have some critical weak points, such as low cycle life, low rate capability, low electrical conductivity. To improve those of weakness of LVO, we prepared carbon coated LVO with sucrose successfully and evaluated their electrochemical properties, such as, relatively crystallinity, small particle size, and electrical conductivity. Furthermore, charge transfer resistance and lithium ion diffusivity was measured by EIS and GITT evaluations to understand relationship coated carbon layer thickness and electrochemical properties. From this result, it is necessary to consider the electrochemical parameters such as the electric conductivity, the charge transfer resistance, and the lithium ion diffusivity depending on the amount of the carbon layer in order to improve the electrochemical property by the carbon coating.
Evaluations of scintillation properties of LiSrAlF<inf>6</inf> scintillator for thermal neutron detection (2010)

Ce 1%, Eu 1%, and Eu 2%-doped LiSrAlF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> (LiSAF) single crystals were grown by the micro-pulling-down (μ-PD) method for thermal neutron applications. The crystals were transparent, 2.0 mm in diameter and 20-40 mm in length. Neither visible inclusions nor cracks were observed. Their transmittance spectra were measured. The strong absorption lines were observed at 200, 240, and 300 nm for Ce:LiSAF due to Ce <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3+</sup> 4f-5d transition. In Eu:LiSAF, 200 (4f-5d) and 300 (4f-4f) nm absorption lines appeared. When they were irradiated by <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">241</sup> Am α-ray simulating neutron excitation, strong emission peak appeared at 300 nm in Ce:LiSAF and 370 nm in Eu:LiSAFs, respectively. Thermal neutron responses were investigated under <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">252</sup> Cf irradiation. The absolute light yield of Ce, Eu 1%, and Eu 2% samples were 3400, 18000, and 30000 ph/n, respectively. Main components of the scintillation decay time of Ce, Eu 1%, and Eu 2%-doped LiSAFs were 63, 1293, and 1205 ns.
Big power from walking (2016)

Dielectric Elastomer Generators (DEG) offer an opportunity to capture the energy otherwise wasted from human motion. By integrating a DEG into the heel of standard footwear, it is possible to harness this energy to power portable devices. DEGs require substantial auxiliary systems which are commonly large, heavy and inefficient. A unique challenge for these low power generators is the combination of high voltage and low current. A void exists in the semiconductor market for devices that can meet these requirements. Until these become available, existing devices must be used in an innovative way to produce an effective DEG system. Existing systems such as the Bi-Directional Flyback (BDFB) and Self Priming Circuit (SPC) are an excellent example of this. The BDFB allows full charging and discharging of the DEG, improving power gained. The SPC allows fully passive voltage boosting, removing the priming source and simplifying the electronics. This paper outlines the drawbacks and benefits of active and passive electronic solutions for maximizing power from walking.
Effects of combinatorial sensing on tracking algorithms for FSO systems (2020)

In free-space optical communication (FSO) photodetectors are used for both data reception and positioning. For most FSO systems, these functions are performed by two separate photodetectors. The development of a new avalanche photodiode (APD) array has allowed positioning and data reception to be done on a single device. This device takes the form of concentric cells with four cells forming a circle and a fifth cell in the center. The change from a standard quadrant cell format to a concentric cell format affects the tracking algorithm an FSO system needs to use. Analytical characterization of the effects of a combinatorial sensor of this type on an FSO tracking algorithm has been done but it has not been verified experimentally. Here we test different tracking algorithms in an existing FSO system to determine the optimal way to use a combinatorial detector for position sensing.
LANDSAT-4 Radiometric and Geometric Correction and Image Enhancement Results (1984)

Techniques were developed or improved to calibrate, enhance, and geometrically correct LANDSAT-4 satellite data. Statistical techniques to correct data radiometry were evaluated and were found to minimize striping and banding. Conventional techniques cause striping even with perfect calibration parameters. Intensity enhancement techniques were improved to display image data with large variation in intensity or brightness. Data were geometrically corrected to conform to a 1:100,000 map reference and image products produced with the map overlay. It is shown that these products can serve as accurate map products. A personal computer was experimentally used for digital image processing.
Spot Friction Welding of Aluminum to Steel (2007)

&lt;div class="htmlview paragraph"&gt;Spot friction welding (SFW) is a cost-effective spot joining technology for aluminum sheets compared with resistance spot welding (RSW) [&lt;span class="xref"&gt;1&lt;/span&gt;]. In this study, coated mild steel was spot friction welded to 6000 series aluminum using a tool with shoulder diameter of 10 mm and welding conditions of 1500-2000 rpm and time of 5 s. Testing showed that tensile shear strength increased as the solidus temperature of the coating on the steel decreased. Microstructure characterizations of steel/Al joint interfaces showed that zinc from the coatings was incorporated into the stir nuggets and that intermetallic phases may have formed but not in continuous layers. Some Al-Zn oxides that appeared to be amorphous were also found in the joint interfaces.&lt;/div&gt;
Rectified catadioptric stereo sensors (2002)

It has been previously shown how mirrors can be used to capture stereo images with a single camera, an approach termed catadioptric stereo. In this paper we present novel catadioptric sensors which use mirrors to produce rectified stereo images. The scan-line correspondence of these images benefits real-time stereo by avoiding the computational cost and image degradation due to resampling when rectification is performed after image capture. First, we develop a theory which determines the number of mirrors that must be used and the constraints on those mirrors that must be satisfied to obtain rectified stereo images with a single camera. Then we discuss in detail the use of both one and three mirrors. In addition, we show how the mirrors should be placed in order to minimize sensor size for a given baseline, an important design consideration.
Stem cell and intermittent parathyroid hormone therapy creates superior regenerate in murine mandibular distraction osteogenesis following radiation (2012)

Deshpande, Sagar Satish BS; Buchman, Steven R. MD, FACS; Donneys, Alexis MD; Gallagher, Kelly K. MD; Tchanque-Fossuo, Catherine N. MD; Sarhaddi, Deniz BA; Weiss, Daniela M. BSc(Hons); Sun, Hongli PhD; Krebsbach, Paul H. DDS DNB, PhD Author Information
Flexible antenna for UWB high-band in sensor network (2010)

An flexible antenna for UWB high-band sensor network is proposed by simulation and measurement. The proposed antenna is designed to be operated in UWB high-band, which provides advantages for emission power level limit. A Flexible circuit board is used to fabricate the proposed antenna for various sensor network environments.
Peroxisome proliferator-activated receptor-γ antagonists exhibit potent antiproliferative effects versus many hematopoietic and epithelial cancer cell lines (2007)

Peroxisome proliferator-activated receptor-gamma ligands have preclinical and clinical anticancer activity. Most studies in this area address agonists, with relatively few reports on anticancer effects of peroxisome proliferator-activated receptor-gamma antagonists. Thus, we evaluated the two pure peroxisome proliferator-activated receptor-gamma antagonists, T0070907 and GW9662, on a panel of hematopoietic and epithelial cell lines. The peroxisome proliferator-activated receptor-gamma antagonists and a reference agonist (pioglitazone) were tested in an in-vitro proliferation assay on a panel of seven hematopoietic and nine epithelial cancer cell lines, some of which are chemoresistant. Peroxisome proliferator-activated receptor-gamma expression was measured by immunoblotting, as was the effect of treatment with these agents on peroxisome proliferator-activated receptor-gamma levels. The effect of exogenous interleukin-6, an antiapoptotic cytokine, on growth inhibition was evaluated as well as the apoptotic effects of these drugs. The peroxisome proliferator-activated receptor-gamma antagonists showed significantly greater potency on all cell lines (IC50s of 3.2-29.7 versus 26.5-78.7 micromol/l for pioglitazone) and greater maximum growth inhibition. Peroxisome proliferator-activated receptor-gamma levels did not correlate with growth inhibition in this panel of cell lines. Combinations of peroxisome proliferator-activated receptor-gamma antagonists and the agonist actually showed schedule-dependent increases in growth inhibition. Exogenous interleukin-6 did not induce resistance to these agents. Both the antagonists and the agonist induced apoptosis, but only the former drugs showed caspase dependence. These two peroxisome proliferator-activated receptor-gamma antagonists have significantly more potent in-vitro antiproliferative effects versus hematopoietic and epithelial cancer cell lines. This effect does not correlate with peroxisome proliferator-activated receptor-gamma levels, suggesting alternative mechanisms or other targets of action. These findings support further translational studies to explore the mechanism of action and therapeutic potential of this class of agents.
Recommendations for an Undergraduate Curriculum at the Interface of Operations Research and Computer Science (2012)

In March 2007, the INFORMS Computing Society formed the ICS Education Committee, charged with outlining an undergraduate curriculum that would prepare students for graduate study and/or industrial work at the interface of operations research and computer science. The result is a set of essential and recommended skills that undergraduate students should seek to acquire in order to be successful in such endeavors. This article presents the findings of the committee.
Amphiphile (2016)

In the past, aggregation and self-assembly have been associated principally with micellar and colloidal systems of molecules; however, with the advent of supramolecular chemistry, molecular self-assembly has been opened to a much wider understanding that has facilitated access to a variety of different shapes and sizes, along with the construction of new and fascinating molecular topologies. This document aims at defining more than 150 terms related to aggregation and self-assembly in the particular case of macromolecules. The list is restricted to the most commonly encountered terms.
Photoacoustic microscopy of microvascular responses to cortical electrical stimulation (2011)

Advances in the functional imaging of cortical hemodynamics have greatly facilitated the understanding of neurovascular coupling. In this study, label-free optical-resolution photoacoustic microscopy (OR-PAM) was used to monitor microvascular responses to direct electrical stimulations of the mouse somatosensory cortex through a cranial opening. The responses appeared in two forms: vasoconstriction and vasodilatation. The transition between these two forms of response was observed in single vessels by varying the stimulation intensity. Marked correlation was found between the current-dependent responses of two daughter vessels bifurcating from the same parent vessel. Statistical analysis of twenty-seven vessels from three different animals further characterized the spatial-temporal features and the current dependence of the microvascular response. Our results demonstrate that OR-PAM is a valuable tool to study neurovascular coupling at the microscopic level.
Plasmonic Nanoantenna Array with Single-Chip Integrated Metal-Organic Framework for Infrared Absorption CO2 Sensing (2017)

Surface-enhanced infrared absorption is a spectroscopic technique but unsuitable for gas spectroscopy due to the need for long absorption path lengths. We demonstrate a device using metal-organic framework integrated with plasmonic nanoantennas for CO2 sensing.
Toward a Four‐Electron Redox Quinone Polymer for High Capacity Lithium Ion Storage (2017)

Abstract Despite recent advances, current polymeric organic cathode materials have failed to incorporate a high degree of lithium storage in a small molecular framework, resulting in low capacities relative to monomers. This report discloses the development of a lithium salt polymer of dihydroxyanthraquinone (LiDHAQS) capable of storing four Li + per monomer. The combination of storing four Li + per monomer and a low molecular weight monomer results in a capacity of 330 mA h g −1 , a record for this class of material. The additional redox events responsible for added Li + storage occur between 3.0 and 3.6 V versus Li/Li + resulting in an average discharge potential of 2.5 V versus Li/Li + . These metrics combined yield a high energy density of 825 W h kg −1 which is a 55% improvement over commercial lithium cobalt oxide. The high performance of LiDHAQS makes it a promising material for next generation Li + cathodes.
Inductor design methods with low-permeability RF core materials (2010)

This paper presents a design procedure for inductors based on low-permeability magnetic materials for use in very high frequency (VHF) power conversion. The proposed procedure offers an easy and fast way to compare different magnetic materials based on Steinmetz parameters and quickly select the best among them, estimate the achievable inductor quality factor and size, and finally design the inductor. Geometry optimization of magnetic-core inductors is also investigated. The proposed design procedure and methods are verified by experiments.
Managing 5G Non-Public Networks from Industrial Automation Systems (2023)

By expanding beyond broadband capabilities of commercial mobile networks and providing novel connectivity features for a wide variety of industry verticals, 5G is becoming a key enabler for the digitalization of industry. However, unlike consumer market where users have very similar communication needs, industrial environments require direct control of security and performance aspects of an underlying networking infrastructure to achieve high communication availability and determinism for a broad range of applications and services. Similarly, it is vital to continuously monitor and verify the connectivity status and performance of devices, especially for mission-critical industrial systems. This paper investigates how to achieve fundamental management capabilities for 5G networks from industrial automation systems, which we refer to as “5G Managed from Industrial Automation”, while hiding “low-level” complexities of the technology. It presents a simplified 5G network management and monitoring solution, designed according to the functional requirements of a process control system, and based on a prototype of 5G system exposure capabilities. In addition, the paper presents details about the design and implementation of the 5G management solution in an ABB industrial automation system and its verification on a private 5G network offered by Ericsson.
A New Facile Chemoenzymatic Synthesis of Levamisole. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans (2012)

African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P<0.0071), were directionally consistent in the Replication cohort and were associated with T2DM in subjects without nephropathy (P<0.05). Meta-analysis in all cases and controls revealed a single SNP reaching genome-wide significance (P<2.5×10(-8)). SNP rs7560163 (P = 7.0×10(-9), OR (95% CI) = 0.75 (0.67-0.84)) is located intergenically between RND3 and RBM43. Four additional loci (rs7542900, rs4659485, rs2722769 and rs7107217) were associated with T2DM (P<0.05) and reached more nominal levels of significance (P<2.5×10(-5)) in the overall analysis and may represent novel loci that contribute to T2DM. We have identified novel T2DM-susceptibility variants in the African-American population. Notably, T2DM risk was associated with the major allele and implies an interesting genetic architecture in this population. These results suggest that multiple loci underlie T2DM susceptibility in the African-American population and that these loci are distinct from those identified in other ethnic populations.
Hybrid Internet Simulation Testbed (1999)

Internet technology as a widely accepted modern telecommunication standard has been widely extended to combine with numerous other technologies, e.g., satellite, ATM, wireless. This is what we term as Hybrid Internet. Along with this technology emerging, various enhancements and alterations of standard TCP/IP for different purposes have been proposed and studied intensively. More and more frequently we are facing the question of how to choose from these different schemes to design a system for a particular purpose, whichwould inevitably involve the interaction and trade-off study. We believe that simulation is a powerful tool for this type of work. In this paper, we describe our implementation of a Hybrid Internet testbed which includes a series of traffic models and TCP/IP enhancements. The goal of our work is to make a set of reusable modules upon whichwe can build complex systems to study the standard protocols and their variations. We also present application examples using these module components.