gebhart/patrepeval huggingface dataset:
Abstract 13742: PDE3 Inhibitor, Cilostazol, Ameliorates Ischemic Hindlimb Through cAMP and PPARγ Activation (2015)

Peripheral arterial disease (PAD) is highly prevalent in the elderly and subjects with atherosclerotic risk factors. Approximately 2-4% of those affected with PAD commonly complain of intermittent claudication (IC) that is a strong indicator for the development of systemic atherosclerosis. Cilostazol (CSZ) has been shown to be of benefit in improving pain-free walking distance and quality of life in patients with IC. CSZ may be the most clinically effective pharmacologic option for IC. However, the underlying mechanism for amelioration of IC by CSZ remains largely unclear. Here, we demonstrate that CSZ increases expression of hepatocyte growth factor (HGF) in vascular smooth muscle cells (SMCs) via two distinct pathways, PPAR γ and cAMP pathway. Activation of PPAR γ and cAMP activates HGF promoter leading to increase in capillary density and improvement of perfusion in mouse ischemic hind limb model. Enhancement of angiogenesis by CSZ involves Akt/eNOS activation in endothelial cells by HGF secreted from SMCs. However, this process was essentially absent in aspirin treatment group and CSZ with HGF neutralizing antibody treatment group. As CSZ also increases HGF protein production in interstitial area of skeletal muscle where satellite cells reside, we postulated that CSZ stimulates myogenesis. To proof this hypothesis, BrdU was injected every day for 7days in mouse hind limb model, and animals were sacrificed at day 7 and 28. Embryonic form of myocyte heavy chain (eMHC), BrdU positive myocyte, and nuclear centralization was measured. As predicted, CSZ increases the number of newly formed myocyte in ischemic leg compared to control and Aspirin treated mouse. This beneficial effect of CSZ was blunted by the administration of HGF neutralizing antibody. Additionally, Heart specific HGF overexpression mouse in which serum level of HGF is 4-5 times higher than wild type mouse were generated to proof the role of HGF in angiogenesis and myogenesis. Similar to the data obtained from CSZ treated mouse, HGF Tg mouse ameliorates ischemic hind limb via both angiogenesis and myogenesis. Altogether, our date demonstrates that CSZ improves ischemic hind limb via angiogenesis and myogenesis. This results may account for the beneficial effect of CSZ in PAD patients with IC.
Correction to “A Genetically Encoded Spin Label for Electron Paramagnetic Resonance Distance Measurements (2014)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to "A Genetically Encoded Spin Label for Electron Paramagnetic Resonance Distance MeasurementsMoritz J. Schmidt, Julia Borbas, Malte Drescher*, and Daniel Summerer*Cite this: J. Am. Chem. Soc. 2014, 136, 17, 6510Publication Date (Web):April 22, 2014Publication History Published online22 April 2014Published inissue 30 April 2014https://pubs.acs.org/doi/10.1021/ja503103thttps://doi.org/10.1021/ja503103tcorrectionACS PublicationsCopyright © 2014 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views786Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (114 KB) Get e-Alertsclose Get e-Alerts
N-Heterocyclic Carbene-Au(I) Complexes Immobilized on Solid Supports (2006)

N-Heterocyclic carbene-Au(I) complexes immobilized on silica gel, ordered mesoporous silica (MCM-41), and delaminated zeolite (ITQ-2) were prepared and used as catalysts in the hydrogenation of alkenes. The reactions of N-heterocyclic carbene-Au(I) complex 1 bearing triethoxy­silyl group with silica gel, MCM-41, and ITQ-2 gave the corresponding solid-supported carbene-Au(I) complexes 2a-c (eq. 1). The hydrogenation of diethyl citraconate and diethyl benzylidenesuccinate took place in the presence of the carbene-Au(I) complexes 2 to give the hydrogenated products with high TOF (eqs. 2 and 3), where the ITQ-2-supported carbene-Au(I) complex 2c showed the highest catalytic activity. The carbene-Au(I) complex 2b was reused three times without significant loss of catalytic activity.
Posture-Dependent Variability in Wrist Ballistocardiogram-Photoplethysmogram Pulse Transit Time: Implication to Cuff-Less Blood Pressure Tracking (2021)

Understanding the physical mechanisms responsible for posture-induced BCG-PPG PTT variability may increase the versatility of the wrist BCG for cuff-less BP tracking.
Crystal and molecular structure of dibromotris(trimethylphosphine)nickel(II). Electronic structures and stereochemistries of the complexes [NiX2(PMe3)3] (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrystal and molecular structure of dibromotris(trimethylphosphine)nickel(II). Electronic structures and stereochemistries of the complexes [NiX2(PMe3)3]James W. Dawson, T. J. McLennan, Ward Robinson, Arlette Merle, Michele Dartiguenave, Yves Dartiguenave, and Harry B. GrayCite this: J. Am. Chem. Soc. 1974, 96, 14, 4428–4435Publication Date (Print):July 1, 1974Publication History Published online1 May 2002Published inissue 1 July 1974https://pubs.acs.org/doi/10.1021/ja00821a014https://doi.org/10.1021/ja00821a014research-articleACS PublicationsRequest reuse permissionsArticle Views96Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A MATLAB based occupant driven dynamic model for predicting residential power demand (2014)

This paper presents a MATLAB based dynamic model for predicting residential power demand. Markov chain based occupant behavior models developed using data gathered by the U.S. Census Bureau in the American Time Use Survey (ATUS) are used in conjunction with models of the most common residential loads to predict residential power demand on a one-second time scale. First, the methods utilized for the modeling of each residential load are presented. Next, an explanation of how these load models are combined with occupant behavior models to predict residential power demand is given. Simulation results showing the overall contribution of each load to the overall residential sector power demand are shown for both winter and summer cases. Finally, future work will involve the use of this high-resolution dynamic residential model to estimate the potential for demand response from residential loads.
Capacity Expansion in Submarine Cable Systems With Bidirectional Transmission Using 4-Core-or-More MCF and MC-EDFA (2023)

Bidirectional transmission in a multicore fiber (MCF) reduces core-to-core crosstalk, changing optimal MCF design and multicore submarine cable systems, compared with conventional unidirectional transmission systems. We first demonstrate analytically the increase in capacity with bidirectional transmission in submarine systems. From the perspective of the capacity of one MCF, we show that bidirectional transmission enables an optimum design based on a 6-core MCF with a standard cladding diameter, taking advantage of the reduction of XT. For multicore submarine cable systems, we demonstrate that 6-core MCF systems with bidirectional transmission offer the highest cable capacity for regional Asian systems in the range of 3,000 km. We further discuss a multicore erbium doped fiber amplifier (MC-EDFA) system even for bidirectional transmission to improve the energy efficiency in submarine systems, and we show that 6-core MCF systems offer the highest capacity up to 6,000 km because of MC-EDFA. We also show a 10 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$\%$</tex-math></inline-formula> larger capacity for a 3,000 km 6-core MCF system, and 43 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$\%$</tex-math></inline-formula> larger capacity for a 9,000 km 4-core MCF system in bidirectional transmission with MC-EDFA, compared with the conventional repeater amplifier in FIFO devices. In addition, we investigated the potential increase in the cable capacity with the future cable system assumption, especially concerning cable supply voltage.
Dynamic Memory Regeneration (2020)

In this paper, we examine a practical implementation of dynamic memory regeneration for the purpose of treating memory loss. Inspired by the refresh cycles in computer Dynamic Random Access Memory (DRAM) circuits, we propose a condensed audiovisual summary that refreshes a subject's memory within a specific amount of time. We explore the impact of the audiovisual refresh cycle time on the overall probability of memory loss, and examine how this refresh time is related to parameters such as refresh cycle duration, and the intrinsic memory loss time. Based on several simplifying assumptions, we propose a model for an ideal memory refresh duration that would minimize the probability of memory loss.
Systementwicklung mit C++ (1995)

So wie ein Schreiner oder Schlosser sein Handwerkszeug beherrschen muß, um seine Arbeit gut und schnell erledigen zu können, stellt sich auch an den Betriebssystem-Programmierer die Forderung, seine Entwicklungswerkzeuge genau zu kennen. In erster Linie ist damit die verwendete Computersprache gemeint. Die in diesem Buch gewählte Sprache ist C++, deren wesentliche Elemente im folgenden Kapitel in Erinnerung gerufen werden.
CD33 as a target of therapy in acute myeloid leukemia: current status and future perspectives (2005)

CD 33 is a myeloid cell surface antigen that is expressed on blast cells in acute myeloid leukemia (AML) in a majority of all patients regardless of age or subtype of disease. The antigen is also expressed on leukemic stem cells in many cases, but is not expressed on normal hematopoietic stem cells. In an attempt to improve therapy in AML, a CD 33-targeted drug has been developed. The drug, gemtucumab ozogamicin (GO; Mylotarg), consists of a humanized CD 33 antibody (hP 67.6), a pH-dependent linker, and a highly potent chemotherapy agent, calicheamicin 1,2,-dimethyl hydrazine dichloride. Based on its clinical activity, GO has been approved for application in chemotherapy-refractory AML in various countries and is effective as a mono-substance as well as in combination with conventional chemotherapy. However, despite high efficacy and a certain specificity for leukemic (as opposed to normal) stem cells, the drug does not work in all patients, and can produce significant side-effects, including veno-occlusive disease (VOD), especially in patients who undergo stem cell transplantation. These side-effects have to be balanced against the benefit of GO therapy in patients with relapsed or refractory AML.
Surfactant mediated deformation of gold particles (1994)

Ultrafine (∽ 20 nm diameter) gold particles produced by the reduction of an aqueous AuCl 3 solution with citric acid have been used as model systems for the study of structural control in systems of nanometersized colloids and for the study of sintering between such particles.Liu has observed that the final, monosized particles evolve from sintered (welded) aggregates (Fig. 1). This process is visible as the color of the gold suspension changes over time. Liu also noted that the ultimate particle size was a function of the gold/citrate ion ratio in the original solution. Similarly, Ferguson et al. have observed the low temperature welding of gold surfaces when organic adsorbates move laterally to increase metalmetal contact. Although Liu has shown that aggregation and deaggregation processes are important in the evolution of colloidal particles, no explanation has been given for the dewelding mechanism of larger aggregates to form discrete particles. In this work, we combine the techniques of electron microscopy and infrared spectroscopy to propose a chemical influence for the dewelding process.
The cationic liposome CCS/C adjuvant induces immunity to influenza independently of the adaptor protein MyD88 (2020)

Traditional non-living vaccines are often least effective in the populations that need them most, such as neonates and elderly adults. Vaccine adjuvants are one approach to boost the immunogenicity of antigens in populations with reduced immunity. Ideally, vaccine adjuvants will increase the seroconversion rates across the population, lead to stronger immune responses, and enable the administration of fewer vaccine doses. We previously demonstrated that a cationic liposomal formulation of the commercial influenza split virus vaccine (CCS/C-HA) enhanced cellular and humoral immunity to the virus, increased seroconversion rates, and improved survival after live virus challenge in a preclinical model, as compared to the commercial vaccine as is (F-HA). We now evaluated vaccine efficacy in different strains and sexes of mice and determined the role of innate immunity in the mechanism of action of the CCS/C adjuvant by testing the response of mice deficient in Toll-like receptors or the TLR/IL-1 adaptor protein MyD88 following immunization with CCS/C-HA vs. F-HA. Although TLR2- and TLR4-deficient mice responded to F-HA immunization, F-HA immunization failed to engender a significant immune response in the absence of MyD88. In contrast, immunization with the CCS/C-HA vaccine overcame the requirement for MyD88 in the response to the commercial vaccine and improved the immune responses and seroconversion rates in all strains of mice tested, including those deficient in TLR2 and TLR4.
Use of flow cytometry to develop and characterize a set of monoclonal antibodies specific for rabbit leukocyte differentiation molecules (2008)

Flow cytometry was used to identify and characterize monoclonal antibodies (mAbs) that react with rabbit leukocyte differentiation molecules (LDM). Screening sets of mAbs, developed against LDM in other species, for reactivity with rabbit LDM yielded 11 mAbs that recognize conserved epitopes on rabbit LDM orthologues and multiple mAbs that recognize epitopes expressed on the major histocompatibility class I or class II molecules. Screening of mAbs submitted to the Animal Homologues Section of the Eighth Human Leukocyte Differentiation Workshop yielded 7 additional mAbs. Screening of mAbs generated from mice immunized with leukocytes from rabbit thymus or spleen or concanavalin A activated peripheral blood and/or spleen lymphocytes has yielded 42 mAbs that recognize species restricted epitopes expressed on one or more lineages of leukocytes. Screening of the anti-rabbit mAbs against leukocytes from other species yielded one additional mAb. The studies show that screening of existing sets of mAbs for reactivity with rabbit LDM will not be productive and that a direct approach will be needed to develop mAbs for research in rabbits. The flow cytometric approach we developed to screen for mAbs of interest offers a way for individual laboratories to identify and characterize mAbs to LDM in rabbits and other species. A web-based program we developed provides a source of information that will facilitate analysis. It contains a searchable data base on known CD molecules and a data base on mAbs, known to react with LDM in one or more species of artiodactyla, equidae, carnivora, and or lagomorpha.
GaN-based distributed-feedback surface-emitting laser with embedded two-dimensional photonic crystal fabricated by mass-transport technique (2010)

We report on GaN-based distributed-feedback surface-emitting lasers on a sapphire substrate. Two-dimensional photonic crystal gratings in our device were embedded into GaN-based structures by mass-transport phenomena. We have observed room-temperature pulsed lasing at 406.0 nm.
Adenoviral Vector Driven by a Minimal Rad51 Promoter Is Selective for p53-Deficient Tumor Cells (2011)

Overall, these experiments demonstrated that a small core domain of the Rad51 promoter can be used to target selective transgene expression from adenoviral vectors to tumor cells lacking functional p53.
Shadow detection using 2D cepstrum (2009)

Shadows constitute a problem in many moving object detection and tracking algorithms in video. Usually, moving shadow regions lead to larger regions for detected objects. Shadow pixels have almost the same chromaticity as the original background pixels but they only have lower brightness values. Shadow regions usually retain the underlying texture, surface pattern, and color value. Therefore, a shadow pixel can be represented as a.x where x is the actual background color vector in 3-D RGB color space and a is a positive real number less than 1. In this paper, a shadow detection method based on two-dimensional (2-D) cepstrum is proposed.
Ohmic Heating Assisted Lye Peeling of Pears (2018)

Our work shows that lye concentrations can be greatly reduced while peeling pears, resulting in significant savings in use of caustic chemicals, reduced costs for effluent treatment and waste disposal.
Regulated and Entangled Photons from a Single Quantum Dot (2000)

We propose a new method of generating nonclassical optical field states. The method uses a semiconductor device, which consists of a single quantum dot as active medium embedded in a p- i- n junction and surrounded by a microcavity. Resonant tunneling of electrons and holes into the quantum dot ground states, together with the Pauli exclusion principle, produce regulated single photons or regulated pairs of photons. We propose that this device also has the unique potential to generate pairs of entangled photons at a well-defined repetition rate.
Extracting Model Parameters and Paradigms From Neutron Imaging of Dead-Ended Anode Operation (2009)

In a PEMFC, feeding dry hydrogen into a dead-ended anode (DEA), reduces the overall system cost, weight and volume due to reduced need for a hydrogen-grade humidification and recirculation subsystems, but requires purging to remove the accumulated water and inert gas. Although the DEA method of operation might be undesirable due to its associated high spatial variability it provides a unique perspective on the evolution of the water accumulation in the anode. Sections of the channel nearest the inlets are significantly drier than those nearest the outlet as shown in the neutron imaging of a 53 cm2 PEMFC. This method allows in-situ visualization of distinct patterns, including water front propagation along the channels. In this paper we utilize neutron imaging of the liquid water distributions and a previously developed PDE model of liquid water flow in the GDL to (a) identify a range of numerical values for the immobile saturation limit, (b) propose a gravity-driven liquid flow in the channels, and (c) derive the two-phase GDL boundary conditions associated with the presence of liquid water in the channel.
Integration of Electrochemical Microsupercapacitors with Thin Film Electronics for On‐Chip Energy Storage (2019)

The development of self-powered electronic systems requires integration of on-chip energy-storage units to interface with various types of energy harvesters, which are intermittent by nature. Most studies have involved on-chip electrochemical microsupercapacitors that have been interfaced with energy harvesters through bulky Si-based rectifiers that are difficult to integrate. This study demonstrates transistor-level integration of electrochemical microsupercapacitors and thin film transistor rectifiers. In this approach, the thin film transistors, thin film rectifiers, and electrochemical microsupercapacitors share the same electrode material for all, which allows for a highly integrated electrochemical on-chip storage solution. The thin film rectifiers are shown to be capable of rectifying AC signal input from either triboelectric nanogenerators or standard function generators. In addition, electrochemical microsupercapacitors exhibit exceptionally slow self-discharge rate (≈18.75 mV h<sup>-1</sup> ) and sufficient power to drive various electronic devices. This study opens a new avenue for developing compact on-chip electrochemical micropower units integrated with thin film electronics.
Rapid and Sensitive Detection of SARS-CoV-2 Infection Using Quantitative Peptide Enrichment LC-MS Analysis (2021)

Abstract Reliable, robust, large-scale molecular testing for SARS-CoV-2 is essential for monitoring the ongoing Covid-19 pandemic. We have developed a scalable analytical approach to detect viral proteins based on peptide immunoaffinity enrichment combined with liquid chromatography - mass spectrometry (LC-MS). This is a multiplexed strategy, based on targeted proteomics analysis and read-out by LC-MS, capable of precisely quantifying and confirming the presence of SARS-CoV-2 in PBS swab media from combined throat/nasopharynx/saliva samples. The results reveal that the levels of SARS-CoV-2 measured by LC-MS correlate well with their corresponding RT-PCR readout (r=0.79). The analytical workflow shows similar turnaround times as regular RT-PCR instrumentation with a quantitative readout of viral proteins corresponding to cycle thresholds (Ct) equivalents ranging from 21 to 34. Using RT-PCR as a reference, we demonstrate that the LC-MS-based method has 100% negative percent agreement (estimated specificity) and 95% positive percent agreement (estimated sensitivity) when analyzing clinical samples collected from asymptomatic individuals with a Ct within the limit of detection of the mass spectrometer (Ct ≤30). These results suggest that a scalable analytical method based on LC-MS has a place in future pandemic preparedness centers to complement current virus detection technologies.