gebhart/patrepeval huggingface dataset:
Understanding complex IT environments using information analytics and visualization (2007)

Today's business environments are going through several major transformations. First, most business environments are increasingly dependent upon vast amount of information. However, in part because of sheer volume, effective use of information is becoming more and more difficult. Second, the IT environments that support businesses are evolving from a simple machine- and automation-centric operational model to a complex people- and interactive service-centric operational model. Where, it becomes critical to analyze and understand the relationships between people, their skills, technologies, and organizations and effectively leverage human and technological resources to drive service delivery excellence and innovation. Unfortunately, very few tools exist to leverage the available information and analyze such relationships. This paper describes a solution, called "Business Insights Workbench" (BIW), which couples a number of information analytics techniques with a unique set of visualizations to help uncover hidden relationships among the key factors of the business environment (e.g., people, their skills, technologies, and organizations). Such understanding can bring many benefits to IT organizations, e.g., effective staffing for projects, collaboration and knowledge sharing, and technology growth and innovation. We use an IT business consulting services (IT BCS) organization as an example to illustrate our approach.
Multiple Sialyl‐Lewisx‐N‐Glycopeptide: Effektive Liganden für E‐Selectin (1996)

Dreifache Fragmentkondensation des Sialyl‐Lewis x ‐Aminbausteins 1 mit Cyclopeptiden führt in einer konvergenten Synthese zu oligovalenten Glycopeptiden mit repetitiven Saccharideinheiten. Ein trivalentes Sialyl‐Lewis x ‐N‐Glycopeptid erwies sich als potenter Antagonist für E‐Selectin. magnified image
ChemInform Abstract: Reaction of the 2‐Nitroenamine in Acid. (1986)

Abstract Das Nitroenamin (Ia) lagert sich in Schwefelsäure zum Amidoxim (III) um.
The Session Description Protocol (SDP) Alternate Connectivity (ALTC) Attribute (2013)

This document proposes a mechanism that allows the same SDP offer to carry multiple IP addresses of different address families (e.g., IPv4 and IPv6). The proposed attribute, the "altc" attribute, solves the backward-compatibility problem that plagued Alternative Network Address Types (ANAT) due to their syntax.
A Solid Diagram Metaphor for Tangible Interaction (2007)

Every approach to interaction design reflects an implicit metaphor held by designers of relationships between the system and user. In the case of interactive research prototypes, as found in ubiquitous computing applications, these implicit metaphors can be inappropriate to real usage scenarios. We propose a novel metaphor of tangible interfaces as being a solid diagram to which we can apply
Spider silk foam coating of fabric (2017)

Abstract Silks are well known natural fibers used for textile applications and have got for the first time available upon sericulture of silkworms ( Bombyx mori ) several thousand years ago in China. In contrast to silkworm silk, spider silks offer better mechanical properties such as higher tensile strength and much better toughness, but natural spider silk is less accessible due to the cannibalistic behavior of spiders prohibiting large scale farming, and therefore has not been employed in textile industry yet. In this study, a biotechnologically produced spider silk protein was introduced as a new material for textile applications in form of foam coating material. The spider silk foam coating was developed to increase the abrasion behavior of natural and polymeric furniture textiles. Modern textiles are high-tech materials and optimized concerning yarn design and fabric weave to fit a wide range of applications. Often hydrofluorocarbons based coatings are used to enhance textile performances. Upon coating with sustainable spider silk, yarn fraying was significantly reduced lowering the tendency to form knots and loops. Further, the textile abrasion resistance, analyzed by pilling tests, was improved significantly (17–200%) for all tested types of fabrics, in particular long term strain pilling was minimized.
Sleep Disturbances in Children with Attention-Deficit/Hyperactivity Disorder (1998)

The sleep profiles of 13 children with attention-deficit/hyperactivity disorder (ADHD) who were treated with a fixed dose of methylphenidate for at least 1 month were compared with those of 16 healthy siblings. Sleep disturbances were assessed according to a structured sleep questionnaire, and the severity of ADHD was evaluated via the Conners Parents Teachers Rating Scale. The results indicated that significantly more children with ADHD demonstrated single or multiple sleep disturbances as well as higher rates of specific sleep disorders, such as initial and middle insomnia, compared with their siblings. No correlation was found between the severity of ADHD and disturbed sleep. Sleep duration and satisfaction with sleep were similar in the two groups. These findings raise important questions regarding the association between ADHD and disturbed sleep.
Protograph E&#x000B2;RC Codes (2008)

We propose a construction of rate-compatible punctured codes based on protographs that have a special E <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> RC structure in their parity part (E <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> RC codes were introduced in Kim, Ramamoorthy and McLaughlin '06) . The protograph representation of these codes facilitates their asymptotic performance analysis and allows the implementation of high speed decoders. The construction process starts with a good high rate protograph. The protographs of lower rate codes are derived from the higher rate protographs via the process of check-splitting. The check-splitting is done in a specific manner so that the parity nodes in the protograph have the special E <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> RC structure. We also present additional design rules that ensure that the gap to capacity remains low across the range of rates. Using our approach we exhibit protographs that have a gap of at most 0.27 dB to capacity across the range of rates 1/2 to 8/9. These conclusions are supported by our simulation results. Our work, therefore presents a systematic method for the design of E <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> RC-like codes.
Tight Bounds on Online Checkpointing Algorithms (2020)

The problem of online checkpointing is a classical problem with numerous applications that has been studied in various forms for almost 50 years. In the simplest version of this problem, a user has to maintain k memorized checkpoints during a long computation, where the only allowed operation is to move one of the checkpoints from its old time to the current time, and his goal is to keep the checkpoints as evenly spread out as possible at all times. Bringmann, Doerr, Neumann, and Sliacan studied this problem as a special case of an online/offline optimization problem in which the deviation from uniformity is measured by the natural discrepancy metric of the worst case ratio between real and ideal segment lengths. They showed this discrepancy is smaller than 1.59-o(1) for all k and smaller than ln 4-o(1)≈ 1.39 for the sparse subset of k ’s, which are powers of 2. In addition, they obtained upper bounds on the achievable discrepancy for some small values of k . In this article, we solve the main problems left open in the above-mentioned paper by proving that ln 4 is a tight upper and lower bound on the asymptotic discrepancy for all large k and by providing tight upper and lower bounds (in the form of provably optimal checkpointing algorithms, some of which are in fact better than those of Bringmann et al.) for all the small values of k ≤ 10. In the last part of the article, we describe some new applications of this online checkpointing problem.
Polymorphism of the dopamine D3 receptor gene associated with opioid dependence (1996)

S: 1996 World Congress on Psychiatric Genetics: V. GENETICS OF DRUG ABUSE (A) AND ALCOHOL (B) (A) DRUG ABUSE: PDF Only
In situ magnetic separation of antibody fragments from Escherichia coli in complex media (2013)

We could demonstrate that triazine-functionalized beads are a suitable low-cost alternative to selectively adsorb D1.3 fragments, and measured maximum loads of 0.08 g D1.3 per g of beads. Although copper-loaded metal-chelate beads did adsorb his-tagged D1.3 well during cultivation, this particle system must be optimized by minimizing metal leakage from the beads in order to avoid negative inhibitory effects on growth of the microorganisms and target production. Hereby, other types of metal chelate complexes should be tested to demonstrate biocompatibility. Such optimized particle systems can be regarded as ISMS platform technology, especially for the production of antibodies and their fragments with low stability in the medium. The proposed model can be applied to design future ISMS experiments in order to maximize the overall product yield while the amount of particles being used is minimized as well as the number of required ISMS steps.
Zinc metabolism in Ehrlich cells: properties of a metallothionein-like zinc-binding protein. (1988)

Host zinc deficiency halts the proliferation of the mouse Ehrlich ascites tumor. The major site of measurable cellular zinc depletion is a cytosolic zinc binding protein. This protein is characterized as a metallothionein on the basis of its presence as two isoproteins which behave on DEAE-Sephadex and in polyacrylamide gel electrophoresis like metallothioneins, the lack of protein absorbance at 280 nm, its sulfhydryl/zinc ratio of 3.5, and its reactivity in zinc transfer to apocarbonic anhydrase. Finally, the protein exhibits cross-reactivity with a known rat metallothionein in a radioimmunoassay. Coupled with the similarity in structure and antigenicity of rat and mouse metallothioneins, this adds strong support to the identification of the zinc-binding protein as a metallothionein. In zinc-deficient cells this metallothionein-like protein appears to exist as an apoprotein. When small amounts of dietary zinc stimulate the deficient cells to divide, zinc is not observed in metallothionein. Larger concentrations of dietary zinc support both proliferation and the steady state presence of zinc in this protein. It is demonstrated that metallothionein is the principal donor of zinc to apocarbonic anhydrase added to Ehrlich cytosol. These results are used to construct a model of zinc metabolism in which zinc metallothionein is a labile depot of zinc in the Ehrlich cell which can be mobilized under zinc-deficient conditions.
Study of Multilevel Programming in Programmable Metallization Cell (PMC) Memory (2009)

Programmable metallization cell (PMC) memory, also known as conductive bridging RAM (CBRAM), is a resistive-switching memory based on non-volatile formation and dissolution of a conductive filament (CF) in a solid electrolyte. Although ease of fabrication, promising performance and multilevel (ML) capability make the PMC a possible candidate for post-flash non-volatile memories, further physical understanding is required to better assess its true potential. In this work, we investigate the kinetics involved in the programming operation (i.e., transition from the high resistance to the low resistance state), which occurs by voltage-driven ion migration and electrochemical deposition, and results in CF formation and growth. The main kinetic parameters controlling the programming operation are extracted from our electrical data. Also, CF growth and corresponding resistance decrease is shown to be controllable with reasonable accuracy in pulse mode by employing a variable load resistance which can dynamically control the programming kinetics. A semi-analytical physical model is shown to account for experimental data and allows for the engineering of fast and reliable ML programming in one transistor-one resistor (1T-1R) devices.
On-Line Algorithms of Stride-Parameter Estimation for in-Shoe Motion-Sensor System (2022)

We propose two on-line algorithms for stride parameter estimation for an in-shoe motion-sensor system (IMS) system: one for on-line stride segmentation based on stable foot-flat detection using foot-sole angle and the other for a three-dimensional zero-velocity-update for accurate stride parameterization. We developed a small and lightweight IMS device, which consists of an inertial measurement unit, micro control unit, and peripheral electrical components, integrated with an insole so that it can be placed inside a shoe at the arch of the foot. Stride parameters, i.e., stride length, walking speed, foot height, circumduction, peak foot sole angle in the dorsiflexion and plantarflexion directions, and toe-in <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$/$ </tex-math></inline-formula> out angle, that characterize a user’s foot motion are estimated. We recruited 30 healthy participants and evaluated the precision of our IMS system by comparing the stride parameters calculated with this system with those acquired from a motion-capture system. The results indicate the precision of the system in terms of the root mean square error for stride length of 0.069 m, walking speed of 0.094 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\text{m}/\text{s}$ </tex-math></inline-formula> , foot height of 1.5 cm, circumduction of 1.0 cm, peak foot-sole angle in the dorsiflexion of 3.3 deg. and in the plantarflexion directions of 5.9 deg., and toe-in <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$/$ </tex-math></inline-formula> out angle of 2.5 deg. Our IMS system has good precision regarding all parameters and high reliability and promises to contribute to personal health and wellness services and solutions by serving as a powerful and practical tool for objective gait assessment in real-world contexts.
Performance and power evaluation of an in-line accelerator (2010)

In this paper we evaluate the performance and power of a processor-attached in-line accelerator. The accelerator provides high-performance SIMD computing and power efficiency by means of a very large register file and a set of vector multimedia extensions based on IBM's PowerPC VMX. Our experiments show significant performance improvements and power reduction, compared to a baseline vector execution unit, mainly due to the drastic decrease of memory accesses caused by the software-managed locality of the very large register file. Total execution time is, on average, reduced by 61%, while consuming 55% less energy.
FPGA implementation of impedance‐compensated phase‐locked loop for HVDC converters (2018)

The phase‐locked loop (PLL) plays a key role in HVDC systems. Recently, a new type of PLL called the impedance‐compensated phase‐locked loop (IC‐PLL) was introduced to compensate for the voltage drop across the AC network's Thevenin impedance, making the phase locking more robust against transients and harmonics. The IC‐PLL has an improved dynamic response as compared with the traditional approaches. However, earlier studies on the IC‐PLL are mainly based on off‐line simulations. In this study, an actual IC‐PLL is constructed in hardware and its performance is investigated by connecting it to a real‐time model of a line‐commutated converter‐based HVDC system on a real‐time digital simulator. The proposed IC‐PLL is constructed using a field‐programmable gate array platform. Paralleled and pipelined structures are implemented on the FPGA to achieve low latency and high speed. The performance of the IC‐PLL is tested by exposing it to different type of system disturbances such as sudden step change in power, voltage magnitude change and voltage distortion. Results are compared with the traditional trans‐vector PLL. The results show the performance of the IC‐PLL is superior.
Venezuelan field trials of vaccines against brucellosis in swine (1998)

Live attenuated B abortus RB51 or purified OPS was effective in protecting gilts against B suis infections. Dose (10(6) to 10(9) cells, 100 to 500 micrograms, respectively), number of doses (1 or 3), or route (IM or PO) made little difference. Further research is required to determine why these 2 vaccine candidates are similar in protection effectiveness and whether they can be used after infection as a treatment.
Identification of HLA-DR alpha chain residues critical for binding of the toxic shock syndrome toxin superantigen. (1992)

Staphylococcal toxic shock syndrome toxin 1 (TSST-1) binds to major histocompatibility complex class II molecules, and the toxin-class II complexes induce proliferation of T cells expressing V beta 2 sequences. To define the residues involved in TSST-1 binding, a set of transfectants expressing 21 HLA-DR alpha chain mutants were analyzed for their abilities to bind and present TSST-1 and to present an antigenic peptide. Mutations at DR alpha positions 36 and 39 markedly decreased the ability of the DR7 molecule to bind and present TSST-1 but did not affect the ability to present an antigenic peptide. These data indicate that DR alpha residues 36 and 39, predicted to be located on an outer loop, are important in the formation of the TSST-1 binding site on DR molecules.
ChemInform Abstract: Palladium‐Catalyzed α‐Arylation of Ketones. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Profile of soluble cytokine-receptors in Crohn’s disease: Serum soluble interleukin(IL)-1 receptor type II (sIL1RII) is a marker of disease activity (2005)

info:eu-repo/semantics/published
Development of devices for self-injection: using tribological analysis to optimize injection force (2016)

This article describes the use of analytical models and physical measurements to characterize and optimize the tribological behavior of pen injectors for self-administration of biopharmaceuticals. One of the main performance attributes of this kind of device is its efficiency in transmitting the external force applied by the user on to the cartridge inside the pen in order to effectuate an injection. This injection force characteristic is heavily influenced by the frictional properties of the polymeric materials employed in the mechanism. Standard friction tests are available for characterizing candidate materials, but they use geometries and conditions far removed from the actual situation inside a pen injector and thus do not always generate relevant data. A new test procedure, allowing the direct measurement of the coefficient of friction between two key parts of a pen injector mechanism using real parts under simulated use conditions, is presented. In addition to the absolute level of friction, the test method provides information on expected evolution of friction over lifetime as well as on expected consistency between individual devices. Paired with an analytical model of the pen mechanism, the frictional data allow the expected overall injection system force efficiency to be estimated. The test method and analytical model are applied to a range of polymer combinations with different kinds of lubrication. It is found that material combinations used without lubrication generally have unsatisfactory performance, that the use of silicone-based internal lubricating additives improves performance, and that the best results can be achieved with external silicone-based lubricants. Polytetrafluoroethylene-based internal lubrication and external lubrication are also evaluated but found to provide only limited benefits unless used in combination with silicone.
[Effect of compound glycyrrhizin on peripheral T-lymphocyte subset in AIDS patients]. (2006)

Compound Glycyrrhizin can lower the expression of active T-lymphocyte subset, inhibit HIV and help immune reconstitution.
The Immune Response to Herpes Simplex Virus Type 1 Infection in Susceptible Mice Is a Major Cause of Central Nervous System Pathology Resulting in Fatal Encephalitis (2008)

This study was undertaken to investigate possible immune mechanisms in fatal herpes simplex virus type 1 (HSV-1) encephalitis (HSE) after HSV-1 corneal inoculation. Susceptible 129S6 (129) but not resistant C57BL/6 (B6) mice developed intense focal inflammatory brain stem lesions of primarily F4/80(+) macrophages and Gr-1(+) neutrophils detectable by magnetic resonance imaging as early as day 6 postinfection (p.i.). Depletion of macrophages and neutrophils significantly enhanced the survival of infected 129 mice. Immunodeficient B6 (IL-7R(-/-) Kit(w41/w41)) mice lacking adaptive cells (B6-E mice) and transplanted with 129 bone marrow showed significantly accelerated fatal HSE compared to B6-E mice transplanted with B6 marrow or control nontransplanted B6-E mice. In contrast, there was no difference in ocular viral shedding in B6-E mice transplanted with 129 or B6 bone marrow. Acyclovir treatment of 129 mice beginning on day 4 p.i. (24 h after HSV-1 first reaches the brain stem) reduced nervous system viral titers to undetectable levels but did not alter brain stem inflammation or mortality. We conclude that fatal HSE in 129 mice results from widespread damage in the brain stem caused by destructive inflammatory responses initiated early in infection by massive infiltration of innate cells.
AnIn VivoOctreoScan-Negative Adrenal Pheochromocytoma Expresses Somatostatin Receptors and Responds to Somatostatin Analogs TreatmentIn Vitro (2003)

A 52-yr-old woman presented with hypertension, elevated urinary vanillylmandelic acid, metanephrines, normetanephrines, and plasma chromogranin A (CgA), but normal urinary catecholamine levels. Abdominal ultrasonography and subsequent MRI imaging showed a 3 cm nodular lesion of the right adrenal gland also visualized by 123I-meta-iodobenzylguanidine scintigraphy consistent with a pheochromocytoma (PC). Her OctreoScan was negative. The patient underwent right adrenalectomy and histological examination showed a PC. The adrenal medulla tissue was examined for somatostatin (SRIH) receptor subtypes 1 to 5 (SSTR1 to 5) expression by RT-PCR. Cultured tumor cells were treated with either SRIH, Lanreotide (Lan), or an SSTR2 (BIM-23 120) or SSTR5 (BIM-23 206) selective agonist. CgA secretion was measured in the medium by ELISA and catecholamine levels by HPLC after 6h. Cell viability was assessed after 48h. RT-PCR analysis showed that SSTR1, 2, 3 and 4 were expressed. CgA secretion was significantly reduced by SRIH (- 80 %), Lan (- 35 %), and the SSTR2 selective agonist (- 65 %). Norepinephrine secretion was reduced by SRIH (- 66 %), Lan (- 40 %), and BIM-23 120 (- 70 %). Epinephrine and dopamine secretion was also inhibited by treatment with SRIH (- 90 % and - 93 %, respectively) and BIM-23 120 (- 33 % and - 75 %, respectively) but not by Lan. Cell viability was also significantly reduced by SRIH (- 30 %), Lan (- 10 %), and the SSTR2 selective agonist (- 20 %). The SSTR5 selective agonist did not modify either CgA and catecholamine secretion or cell viability. Our data show that SSTRs may be present in a PC although OctreoScan is negative in vivo, and that SRIH and its analogs may reduce both differentiated and proliferative functions in chromaffin cells in vitro. These findings suggest that SRIH analogs with enhanced SSTR2 affinity might be useful in the medical therapy of PC, even when an OctreoScan is negative.