gebhart/patrepeval huggingface dataset:
Figure S7 from LAMC2 Regulates Key Transcriptional and Targetable Effectors to Support Pancreatic Cancer Growth (2023)

&lt;p&gt;Suppl. Figure 7. A. KRAS, TP53, SMAD4 genetic alteration in the 2 PDO characterized by DNA sequencing.&lt;/p&gt;
Tandem transducer magnet structure (1995)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Earl Geddes; Tandem transducer magnet structure. J. Acoust. Soc. Am. 1 October 1995; 98 (4): 1831. https://doi.org/10.1121/1.414406 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Subgingival Aggregatibacter actinomycetemcomitans associates with the risk of coronary artery disease (2013)

The presence of subgingival A. actinomycetemcomitans associates with an almost twofold risk of Stable CAD independently of alveolar bone loss.
Energy services for the smart grid city (2012)

The smart grid enabled city is an emerging complex system of systems where different stakeholders will have to strive towards achieving their goals while interacting with each-other. At parts of the city such as the districts, the energy signature and efforts towards its better energy efficiency will heavily depend on the utilization of availability and optimal usage of the local resources. The latter may be very dynamic and depend on several complex conditions such as weather, prosumer behavioural patterns, business interactions etc. An emergent city-wide behaviour appears when a number of simple entities i.e. the prosumers, operate in an environment, forming more complex behaviours as a collective. In order to empower the smart grid city, several energy services capturing the common needs of all stakeholders need to be made available to them. As a result of a (potentially) common platform that offers basic energy services, rapid development of applications can be realized without the need to start from scratch. Such energy services have been identified, analysed and implemented, in the context of a wider enterprise system architecture. An insight on their functionality, usage and development challenges and experiences is provided.
Glutamatergic receptor dysfunction in spinal cord contributes to the exaggerated exercise pressor reflex in heart failure (2014)

Excitatory amino acids (e.g., glutamate) released by contraction-activated skeletal muscle afferents into the dorsal horn of the spinal cord initiate the central component of the exercise pressor reflex (EPR) in physiological conditions. However, the role of glutamate and glutamate receptors in mediating the exaggerated EPR in the chronic heart failure (CHF) state remains to be determined. In the present study, we performed microinjection of glutamate receptor antagonists into ipisilateral L4/L5 dorsal horns to investigate their effects on the pressor response to static contraction induced by stimulation of the peripheral end of L4/L5 ventral roots in decerebrate sham-operated (sham) and CHF rats. Microinjection of glutamate (10 mM, 100 nl) into the L4 or L5 dorsal horn caused a greater pressor response in CHF rats compared with sham rats. Furthermore, microinjection of either the broad-spectrum glutamate receptor antagonist kynurenate (10 mM, 100 nl) or the N-methyl-d-aspartate (NMDA) receptor antagonist dl-2-amino-5-phosphonovalerate (50 mM, 100 nl) or the non-NMDA-sensitive receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (5 mM, 100 nl) into L4/5 dorsal horns decreased the pressor response to static contraction in CHF rats to a greater extent than in sham rats. Molecular evidence showed that the protein expression of glutamate receptors (both non-NMDA and NMDA) was elevated in the dorsal horn of the lumbar spinal cord in CHF rats. In addition, data from microdialysis experiments demonstrated that although basal glutamate release at the dorsal horn at rest was similar between sham and CHF rats (225 ± 50 vs. 260 ± 63 nM in sham vs. CHF rats, n = 4, P > 0.05), CHF rats exhibit greater glutamate release into the dorsal horn during muscle contraction compared with sham rats (549 ± 60 vs. 980 ± 65 nM in sham vs. CHF rats, n = 4, P < 0.01). These data indicate that the spinal glutamate system contributes to the exaggerated EPR in the CHF state.
Transplanted Adult Bone Marrow Cells Repair Myocardial Infarcts in Mice (2001)

Occlusion of the anterior descending left coronary artery leads to ischemia, infarction, and loss of function in the left ventricle. We have studied the repair of infarcted myocardium in mice using highly enriched stem/progenitor cells from adult bone marrow. The left coronary artery was ligated and 5 hours later Lin- c-kit+ bone marrow cells obtained from transgenic male mice expressing enhanced green fluorescent protein (EGFP) were injected into the healthy myocardium adjacent to the site of the infarct. After 9 days the damaged hearts were examined for regenerating myocardium. A band of new myocardium was observed in 12 surviving mice. The developing myocytes were small and resembled fetal and neonatal myocytes. They were positive for EGFP, Y chromosome, and several myocyte-specific proteins including cardiac myosin, and the transcription factors GATA-4, MEF2, and Csx/Nkx2.5. The cells were also positive for connexin 43, a gap junction/intercalated disc component indicating the onset of intercellular communication. Myocyte proliferation was demonstrated by incorporation of BrdU into the DNA of dividing cells and by the presence of the cell cycle-associated protein K167 in their nuclei. Neo-vascularization was also observed in regenerating myocardium. Endothelial and smooth muscle cells in developing capillaries and small arterioles were EGFP-positive. These cells were positive for Factor VIII and alpha smooth muscle actin, respectively. No myocardial regeneration was observed in damaged hearts transplanted with Lin- c-kit- bone marrow cells, which lack bone marrow-regenerating activity. Functional competence of the repaired left ventricle was improved for several hemodynamic parameters. These in vivo findings demonstrate the capacity of highly enriched Lin- c-kit+ adult bone marrow cells to acutely regenerate functional myocardium within an infarcted region.
DCE-MRI with free-breathing compressed sensing VIBE for predicting chemotherapy response and patient outcome in pancreatic adenocarcinoma (2023)

This study focused on the feasibility of dynamic contrast-enhanced MRI (DCE-MRI) with motion-resolved compressed sensing T1-weighted volumetric interpolated breath-hold examination (CS-VIBE) for prediction of treatment response to chemotherapy and patient outcome in pancreatic ductal adenocarcinoma (PDAC). Our results showed tumor ve was significantly higher in the response group than in the non-response group and was an independent predictor of progression-free survival in patients with PDAC treated with chemotherapy. These results suggest that DCE-MRI obtained with CS-VIBE may be useful for predicting treatment response to chemotherapy and patient outcome in PDAC.
Theoretical and Numerical Aspects of Transmit SENSE (2004)

The ideas of parallel imaging techniques, designed to shorten the acquisition time by the simultaneous use of multiple receive coils, can be adapted for parallel transmission of a spatially selective multidimensional RF pulse. In analogy to data acquisition, a multidimensional RF pulse follows a certain trajectory in k-space. Shortening this trajectory shortens the pulse duration. The use of multiple transmit coils, each with its own time-dependent waveform and spatial sensitivity, compensates for the missing parts of k-space. This results in a maintained spatial definition of the pulse profile while its duration is reduced. This paper describes the basic equations of parallel transmission with arbitrarily shaped transmit coils ("Transmit SENSE") focusing on two-dimensional RF pulses. Results of numerical studies are presented demonstrating the theoretical feasibility of the approach.
Neural network regularization and ensembling using multi-objective evolutionary algorithms (2004)

Regularization is an essential technique to improve generalization of neural networks. Traditionally, regularization is conducted by including an additional term in the cost function of a learning algorithm. One main drawback of these regularization techniques is that a hyperparameter that determines to which extension the regularization influences the learning algorithm must be determined beforehand. This paper addresses the neural network regularization problem from a multi-objective optimization point of view. During the optimization, both structure and parameters of the neural network will be optimized. A slightly modified version of two multi-objective optimization algorithms, the dynamic weighted aggregation (DWA) method and the elitist non-dominated sorting genetic algorithm (NSGA-II) are used and compared. An evolutionary multi-objective approach to neural network regularization has a number of advantages compared to the traditional methods. First, a number of models with a spectrum of model complexity can be obtained in one optimization run instead of only one single solution. Second, an efficient new regularization term can be introduced, which is not applicable to gradient-based learning algorithms. As a natural by-product of the multi-objective optimization approach to neural network regularization, neural network ensembles can be easily constructed using the obtained networks with different levels of model complexity. Thus, the model complexity of the ensemble can be adjusted by adjusting the weight of each member network in the ensemble. Simulations are carried out on a test function to illustrate the feasibility of the proposed ideas.
Eliminating Exposure Bias and Loss-Evaluation Mismatch in Multiple Object Tracking (2018)

Identity Switching remains one of the main difficulties Multiple Object Tracking (MOT) algorithms have to deal with. Many state-of-the-art approaches now use sequence models to solve this problem but their training can be affected by biases that decrease their efficiency. In this paper, we introduce a new training procedure that confronts the algorithm to its own mistakes while explicitly attempting to minimize the number of switches, which results in better training. We propose an iterative scheme of building a rich training set and using it to learn a scoring function that is an explicit proxy for the target tracking metric. Whether using only simple geometric features or more sophisticated ones that also take appearance into account, our approach outperforms the state-of-the-art on several MOT benchmarks.
Signals (2006)

Signals are letters to the editor submitted by readers of The Leading Edge.
Subfascial Implantation of Intrathecal Baclofen Pumps in Children: Technical Note (2001)

Abstract OBJECTIVE Indwelling intrathecal drug delivery systems are becoming increasingly important as a method of neuromodulation within the nervous system. In particular, intrathecal baclofen therapy has shown efficacy and safety in the management of spasticity and dystonia in children. The most common complications leading to explantation of the pumps are skin breakdown and infection at the pump implantation site. The pediatric population poses particular challenges with regard to these complications because appropriate candidates for intrathecal baclofen therapy are often undernourished and thus have a dearth of soft tissue mass to cover a subcutaneously implanted baclofen pump. We report a technique of subfascial implantation that provides greater soft tissue coverage of the pump, thereby reducing the potential for skin breakdown and improving the cosmetic appearance of the implantation site. METHODS Eighteen consecutively treated children (average age, 8 yr, 7 mo) with spasticity and/or dystonia underwent subfascial implantation of a baclofen pump. These children's mean weight of 42.9 lb is less than the expected weight for a group of children in this age group, ranging from 4 years, 8 months, to 15 years, 7 months. In all patients, the pump was inserted into a pocket surgically constructed between the rectus abdominus and the external oblique muscles and the respective anterior fascial layers. RESULTS At an average follow-up of 13.7 months, no infection or skin breakdown had occurred at the pump surgical site in any of the 18 patients. CONCLUSION At this early follow-up, the subfascial implantation technique was associated with a reduced rate of local wound and pump infections and provided optimal cosmetic results as compared with that observed in retrospective cases.
Direction-adaptive transforms for coding prediction residuals (2010)

In this paper, we present 2-D direction-adaptive transforms for coding prediction residuals of video. These Direction-Adaptive Residual Transforms (DART) are shown to be more effective than the traditional 2-D DCT when coding residual blocks that contain directional features. After presenting the directional transform structures and improvements to their efficiency, we outline how they are used to code both Inter and Intra prediction residuals. For Intra coding, we also demonstrate the relation between the prediction mode and the optimal DART orientation. Experimental results exhibit up to 7% and 9.3% improvements in compression efficiency in JM 16.0 and JM-KTA 2.6r1 respectively, as compared to using only the conventional H.264/AVC transform.
2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure (2021)

TEST 02 - Elsevier's Scopus, the largest abstract and citation database of peer-reviewed literature. Search and access research from the science, technology, medicine, social sciences and arts and humanities fields.
Experimental investigation of IEEE802.11n reception with fractional sampling (2010)

In the IEEE802.11n WLAN standard, orthogonal frequency division multiplexing (OFDM) modulation is employed. Diversity techniques are implemented to overcome multipath fading in the OFDM systems. A fractional sampling (FS) scheme is one of the diversity techniques with a single antenna. This scheme also can be applied in a MIMO-OFDM system to increase its capacity. In this paper, the effect of FS in a WLAN system following the IEEE802.11n standard is investigated through experiments. Numerical results through the experiments indicate that diversity gain through FS can be obtained in the NLOS conditions.
Thiazoyl phosphines. Design, reactivity, and complexation (2016)

In spite of the numerous possible applications of thiazoles as ligands for catalysis and as active molecules in medicinal chemistry, only a few studies have dealt with their versatile chemistry. Several selective modifications of the structure of these derivatives and mainly of thiazoyl phosphines are detailed, thus illustrating the great possibilities to tailor at will their structures and therefore their properties. The formation of Ru and Au complexes is reported. Six of these new thiazoyl phosphines were characterized by X-ray crystallography as well as two of their gold complexes.
An architecture for TV content distributed search and retrieval using the MPEG query format (MPQF) (2008)

Traditional broadcasting of TV contents begins to coexist with new models of user aware content delivery. The definition of interoperable interfaces for precise content search and retrieval between the different involved parties is a requirement for the deployment of the new audiovisual distribution services. This paper presents the design of an architecture based on the MPEG Query Format (MPQF) for providing the necessary interoperability to deploy distributed audiovisual content search and retrieval networks between content producers, distributors, aggregators and consumer devices. A service-oriented architecture based on Web Services technology is defined. This paper also presents how the architecture can be applied to a real scenario, the XAC (Xarxa IP Audiovisual de Catalunya, Audiovisual IP Network of Catalonia). As far as we know, this is the first paper to apply MPQF to TV Content Distributed Search and Retrieval.
Chemical Insights into PbSe–x%HgSe: High Power Factor and Improved Thermoelectric Performance by Alloying with Discordant Atoms (2018)

Thermoelectric generators can convert heat directly into usable electric power but suffer from low efficiencies and high costs, which have hindered wide-scale applications. Accordingly, an important goal in the field of thermoelectricity is to develop new high performance materials that are composed of more earth-abundant elements. The best systems for midtemperature power generation rely on heavily doped PbTe, but the Te in these materials is scarce in the Earth's crust. PbSe is emerging as a less expensive alternative to PbTe, although it displays inferior performance due to a considerably smaller power factor S<sup>2</sup>σ, where S is the Seebeck coefficient and σ is electrical conductivity. Here, we present a new p-type PbSe system, Pb<sub>0.98</sub>Na<sub>0.02</sub>Se- x%HgSe, which yields a very high power factor of ∼20 μW·cm<sup>-1</sup>·K<sup>-2</sup> at 963 K when x = 2, a 15% improvement over the best performing PbSe- x%MSe materials. The enhancement is attributed to a combination of high carrier mobility and the early onset of band convergence in the Hg-alloyed samples (∼550 K), which results in a significant increase in the Seebeck coefficient. Interestingly, we find that the Hg<sup>2+</sup> cations sit at an off-centered position within the PbSe lattice, and we dub the displaced Hg atoms "discordant". DFT calculations indicate that this feature plays a role in lowering thermal conductivity, and we believe that this insight may inspire new design criteria for engineering high performance thermoelectric materials. The high power factor combined with a decrease in thermal conductivity gives a high figure of merit ZT of 1.7 at 970 K, the highest value reported for p-type PbSe to date.
Multi-objective Tracking Applied to Bat Populations (2016)

Multiple target tracking is one of the great challenges faced by the computer vision community in last years. This paper presents a solution developed in order to track bats in a clutter environment to account the population of their colony. The algorithm is able to start detections, treat wrong or lost detections and process the detections in progress. Tracked targets have their next state estimated by Kalman Filter usage. As new measurements are performed, the algorithm can identify which of them are considered noise, which are new targets and which are new states of a previously detected target. A 3D viewer was also implemented in order to help the analysis of the tracked flights by researchers in areas like biodiversity and biology. The aim of this paper is to present the operation of the developed system, collaborate with other researchers working with tracking of multiple objects and make society aware of the importance of preserving the environment, exposing some of the consequences of changing its natural characteristics. The proposed algorithm showed amazing results in the test stages, reaching to overcome the current state of the art.
Data from Differentiation of NUT Midline Carcinoma by Epigenomic Reprogramming (2023)

&lt;div&gt;Abstract&lt;p&gt;NUT midline carcinoma (NMC) is a lethal pediatric tumor defined by the presence of BRD-NUT fusion proteins that arrest differentiation. Here we explore the mechanisms underlying the ability of BRD4-NUT to prevent squamous differentiation. In both gain-of and loss-of-expression assays, we find that expression of BRD4-NUT is associated with globally decreased histone acetylation and transcriptional repression. Bulk chromatin acetylation can be restored by treatment of NMC cells with histone deacetylase inhibitors (HDACi), engaging a program of squamous differentiation and arrested growth &lt;i&gt;in vitro&lt;/i&gt; that closely mimics the effects of siRNA-mediated attenuation of BRD4-NUT expression. The potential therapeutic utility of HDACi differentiation therapy was established in three different NMC xenograft models, where it produced significant growth inhibition and a survival benefit. Based on these results and translational studies performed with patient-derived primary tumor cells, a child with NMC was treated with the FDA-approved HDAC inhibitor, vorinostat. An objective response was obtained after five weeks of therapy, as determined by positron emission tomography. These findings provide preclinical support for trials of HDACi in patients with NMC. &lt;i&gt;Cancer Res; 71(7); 2686–96. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Optical Coherence Microscopy using a Handheld Probe and Novel Phase Modulator (2002)

An optical coherence microscope is demonstrated using a hand-held probe and a reflective grating delay line for broadband phase modulation. Real time, cellular imaging with 3 um transverse resolution is achieved.
Correlation of binding of rabbit granulocyte peptides to Candida albicans with candidacidal activity (1985)

NP-1, a candidacidal peptide purified from rabbit granulocytes, bound extensively and with biphasic kinetics to Candida albicans. The primary phase of binding was temperature independent and occurred even at 0 degrees C. This primary binding was relatively specific, reversible, saturable, and of high capacity. It was inhibited by increased salt concentrations in the incubation medium, but was relatively unaffected by increasing the calcium ion concentration or by lowering the incubation temperature to 0 degrees C. The secondary phase of binding was only noted under conditions that supported candidacidal activity. Secondary binding was inhibited by millimolar concentrations of calcium, but not magnesium, ions and did not occur at 0 degrees C or when subtoxic concentrations of NP-1 were tested. NP-2 and NP-3a, other potent candidacidal peptides from rabbit granulocytes, also bound directly and extensively to C. albicans and competed for binding with NP-1. NP-4 and NP-5, less candidacidally active homologs of the aforementioned peptides, showed relatively little direct binding activity and competed poorly for binding with NP-1 or NP-2. NP-3b, another less candidacidal homolog, bound extensively to C. albicans, but did not compete effectively with NP-1 or NP-2. By comparing candidacidal and binding activity of the peptides, we conclude that the candidacidal activity of NP-1 involves primary binding to C. albicans followed by postbinding events that are temperature dependent and inhibitable by calcium ions.