gebhart/patrepeval huggingface dataset:
Design, Synthesis and Discovery of Picomolar Selective α4β2 Nicotinic Acetylcholine Receptor Ligands (2013)

Developing novel and selective compounds that desensitize α4β2 nicotinic acetylcholine receptors (nAChRs) could provide new effective treatments for nicotine addiction, as well as other disorders. Here we report a new class of nAChR ligands that display high selectivity and picomolar binding affinity for α4β2 nicotinic receptors. The novel compounds have Ki values in the range of 0.031-0.26 nM and properties that should make them good candidates as drugs acting in the CNS. The selected lead compound 1 (VMY-2-95) binds with high affinity and potently desensitizes α4β2 nAChRs. At a dose of 3 mg/kg, compound 1 significantly reduced rat nicotine self-administration. The overall results support further characterizations of compound 1 and its analogues in preclinical models of nicotine addiction and perhaps other disorders involving nAChRs.
Significant Zirconium−Alkyl Group Effects on Ion Pair Formation Thermodynamics and Structural Reorganization Dynamics in Zirconocenium Alkyls (1999)

Substantial Zr−alkyl group (R) effects on ion pair thermodynamic stability as well as on ion pair solution structure and structural dynamics are reported in the [(1,2-Me2Cp)2ZrR]+[CH3B(C6F5)3]- series, where R = CH3, CH2C(CH3)3, CH2Si(CH3)3, and CH[Si(CH3)3]2. These quantitative results underscore the effects such R moieties are likely to play in group 4 metallocenemediated olefin polymerization catalysis.
1348 BDC-3042: A Dectin-2 agonistic antibody for tumor-associated macrophage-directed immunotherapy (2022)

<h3>Background</h3> Tumor-associated macrophages (TAMs) generally support tumor progression through their immunosuppressive effects on the tumor microenvironment (TME) and are the predominant immune cell population in most cancers. TAMs express the pattern recognition receptor Dectin-2 (<i>CLEC6A</i>), an activating C-type lectin receptor (CLR) that binds to high-mannose glycans on fungi and other microbes and induces protective immune responses against infectious disease. Dectin-2 ligation mediates enhanced phagocytosis, antigen processing and presentation, and proinflammatory cytokine production. Agonism of Dectin-2 on TAMs using naturally derived ligands drives potent anti-tumor immunity in syngeneic mouse tumor models. Given these findings, we developed a human Dectin-2-targeted agonistic antibody, BDC-3042, which is capable of robustly activating TAMs as a novel approach to myeloid-directed immunotherapy. <h3>Methods</h3> Dectin-2 expression was assessed by flow cytometry, immunohistochemistry, and using public databases. Human whole blood, monocyte-derived macrophages, and single-cell suspensions from dissociated human tumors were stimulated overnight with BDC-3042. Activation was assessed through cytokine analysis. Immune profiling and anti-tumor efficacy were assessed in vivo utilizing MDA-MB-231 tumor-bearing CD34+ HSC engrafted mice (huNOG-EXL, Taconic Biosciences). <h3>Results</h3> Dectin-2 is expressed by TAMs across many tumor types, including breast, colon, and lung cancers, but exhibits minimal expression in most normal tissues. BDC-3042 binds to recombinant Dectin-2 and Dectin-2-expressing cells with low-nanomolar affinity. BDC-3042 elicits robust activation of primary TAMs and in vitro-generated macrophages, leading to secretion of proinflammatory mediators characteristic of tumor-destructive “M1” macrophages, such as TNFa, IL-1b, and CCL3/4. Low levels of BDC-3042 binding are detected on blood monocytes, with minimal binding to other peripheral immune cells. Importantly, BDC-3042 elicits little to no activation of peripheral monocytes or cells in whole blood. BDC-3042 activity is dependent on both Dectin-2 and FcgRs, as indicated by the increased activation of macrophages elicited with an Fc-enhanced IgG1 backbone. Systemically administered BDC-3042 activates TAMs and mediates anti-tumor efficacy in mice with humanized immune systems. <h3>Conclusions</h3> The data presented demonstrate the therapeutic potential of targeting Dectin-2 expressed by TAMs with the agonistic antibody BDC-3042 as a novel pan-cancer approach for myeloid cell-directed tumor immunotherapy.
Hybrid full/half wave inverter designed for low cost induction heating appliances (2011)

We present a new inverter topology used for domestic induction heating purposes. The system is orientated to lower cost platforms, where price must be minimized. With regard to traditional solution for this market, proposed system does not increase cost (only adds two extra relays) and achieves better performance. The proposed system increases life-time of switching relays by ensuring zero-current switching. It also simplifies power control strategy because of full cancelation of intermodulation noise. By eliminating this problem, every inverter is completely independent to each other, and control strategy results quite simple. A full efficiency analysis was performed. Results are quite significant, obtaining a losses reduction ratio close to 30%. The complete operation and analysis, and also the design difficulties are explained in detail.
Ligand Substitution Dynamics (1968)

Substitution of a ligand in an inner sphere complex by an outside group
is the most fundamental reaction in metal ion chemistry
DQN-based Beamforming for Uplink mmWave Cellular-Connected UAVs (2021)

Unmanned aerial vehicles (UAVs) are the emerging vital components of millimeter wave (mmWave) wireless systems. Accurate beam alignment is essential for efficient beam-based mmWave communications of UAVs with base stations (BSs). Conventional beam sweeping approaches often have large overhead due to the high mobility and autonomous operation of UAVs. Learning-based approaches greatly reduce the overhead by leveraging UAV data, like position to identify optimal beam directions. In this paper, we propose a reinforcement learning (RL)-based framework for UAV-BS beam alignment using deep Q-Network (DQN) in a mmWave setting. We consider uplink communications where the UAV hovers around 5G new radio (NR) BS coverage area, with varying channel conditions. The proposed learning framework uses the location information to maximize data rate through the optimal beam-pairs efficiently, upon every communication request from UAV inside the multi-location environment. We compare our proposed framework against the Multi-Armed Bandit (MAB) learning-based approach and the traditional exhaustive approach, respectively, and also analyse the training performance of DQN-based beam alignment over different coverage area requirements and channel conditions. Our results show that the proposed DQN-based beam alignment converges faster and generic for different environmental conditions. The framework can also learn optimal beam alignment comparable to the exhaustive approach in an online manner under real-time conditions.
Wideband antenna for mobile terminals using a coupled feeding structure (2011)

A wideband antenna which consists of a planar inverted F-antenna (PIFA) with a coupled feeding structure for wireless terminals is presented. The operating bandwidth of the proposed antenna is from 820 MHz to 3 GHz, as far as we know, this is the first antenna which covers entire bands of wireless communication applications (GSM850 / GSM900 / GPS / DCS1800 / PCS1900 / WCDMA1700 / WCDMA2100 / WiBro2350 / Bluetooth (BT) / Wi-Fi / WiMAX2500 and Long Term Evolution (LTE) 2600). Therefore, it can be used as current 2G/3G/4G services as well as GPS. In addition, the antenna has small size, 20 × 40 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , and can be directly printed on no-ground region of system circuit board. The overall area of Printed Circuit Board (PCB) including antenna area is 40 × 100 × 0.8 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> . As a result, the proposed antenna is suitable for compact mobile applications and small wireless devices.
Contribution au développement d’une sonde optique pour la mesure de tension dans les circuits numériques (2001)

International audience
Does TMS Hold Promise for Generalized Anxiety Disorder (2015)

Available data suggest that transcranial magnetic stimulation holds promise as a treatment for GAD. Here: a look at what we know.
The chiral structure of 1H-indazoles in the solid state: a crystallographic, vibrational circular dichroism and computational study (2012)

A survey of the Cambridge Crystallographic Database reveals that there are 17 1H-indazoles forming dimers (7), trimers (4) and catemers or chains (6). Amongst the catemers there is one centrosymmetric compound and five non-centrosymmetric ones that crystallize in chiral helices, either M or P, including indazole itself, whose structure has been determined anew. An explanation will be provided for how an achiral molecule crystallizes in a chiral space group. The second part of the paper is devoted to the use of Vibrational Circular Dichroism (VCD) for determining the absolute configuration of a crystal of indazole. This previously needs the complete assignment of its IR and Raman spectra in solution and in the solid-state based on B3LYP/6-31G(d) calculations of indazole dimers and trimers, which are already chiral.
Targeting B cells for the treatment of rheumatoid arthritis. (2003)

The role of B cells in rheumatoid arthritis (RA) has been debated for decades. However, recent clinical trial data indicating that depletion of B cells in RA patients is of therapeutic benefit has validated the importance of this cell type in the pathogenesis of the disease. Elucidation of the molecular basis of B cell development and activation has allowed the identification of a number of possible therapeutic targets that are appealing for drug development. This review discusses briefly a number of these molecules and the rationale for targeting them for the treatment of RA.
SCLERAL BUCKLING WITH WIDE-ANGLED ENDOILLUMINATION AS A SURGICAL EDUCATIONAL TOOL (2015)

Chandelier-assisted buckling had similar outcomes compared with standard buckling. It could be used as a valuable educational tool for teaching fellows by allowing them to simultaneously view the operative steps along with the surgeon.
The Design of A Distributed Rating Scheme for Peer-to-peer Systems (2007)

There exist many successful examples of online reputation (or rating) systems, such as on-line markets and e-tailer ratings. However, for peer-to-peer applications, an explicit ratings subsystem has often been ignored in system design because of the implicit assumption of trust and altruism among P2P users. This assumption might be true (or might not matter) when a P2P network is still in its infancy and is relatively small in size. But the assumption might break down with increase in the size and diversity of the P2P network. In this paper, we discuss issues in the design of rating schemes for P2P systems. In keeping with the design philosophy of many of these system, we consider the design of distributed rating systems. As a case study, we illustrate two different approaches to a distributed rating system aimed at tackling the free-rider problem in P2P networks. A key challenge in designing such rating schemes is to make them collusion-proof: we discuss our efforts in this direction. I.
Electronic spectral study of some iron(II) magnetic isomers in solution and a spectral-structural correlation with their nickel(II) analogs (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic spectral study of some iron(II) magnetic isomers in solution and a spectral-structural correlation with their nickel(II) analogsLon J. Wilson, Danae. Georges, and Mitchell A. HoseltonCite this: Inorg. Chem. 1975, 14, 12, 2968–2975Publication Date (Print):December 1, 1975Publication History Published online1 May 2002Published inissue 1 December 1975https://pubs.acs.org/doi/10.1021/ic50154a023https://doi.org/10.1021/ic50154a023research-articleACS PublicationsRequest reuse permissionsArticle Views180Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Direct visualization and quantitative analysis of water diffusion in complex biological tissues using CARS microscopy (2013)

To date, it has not been possible to measure microscopic diffusive water movements in epithelia and in the interstitial space of complex tissues and organs. Diffusive water movements are essential for life because they convey physiologically important small molecules, e.g. nutrients and signaling ligands throughout the extracellular space of complex tissues. Here we report the development of a novel method for the direct observation and quantitative analysis of water diffusion dynamics in a biologically organized tissue using Coherent Anti-Stokes Raman Scattering (CARS) microscopy. Using a computer simulation model to analyze the CARS O-H bond vibration data during H2O/D2O exchange in a 3D epithelial cyst, we succeeded in measuring the diffusive water permeability of the individual luminal and basolateral water pathways and also their response to hormonal stimulation. Our technique will be applicable to the measurement of diffusive water movements in other structurally complex and medically important tissues and organs.
Cloning and characterization of the pyrH gene encoding UMP-kinase from Lactobacillus reuteri ATCC 55739 (2005)

From a genomic library of Lactobacillus reuteri ATCC 55739, one clone, NE347, carrying a pyrH gene encoding UMP kinase, was identified. pNE347 carried a 1.88 kb EcoRI fragment and the pyrH was located in the middle of the insert. pyrH ORF was 723 bp in size and capable of encoding UMP kinase composed of 240 amino acid residues, tsf encoding an elongation factor-Ts and frr encoding a ribosomal recycling factor were present upstream and downstream of pyrH, respectively. When introduced into E. coli KUR1244, a pyrH-negative strain, pNE347 restored the ability to grow at 42°C, indicating that pyrH from L. reuteri synthesized functional UMP kinase in E. coli. Northern blot experiment showed that pyrH and frr were cotranscribed as a 1.4 kb single transcript. pyrH was overexpressed in E. coli by using a pET26b(+) vector, and a major 25 kDa protein band appeared on SDS-polyacrylamide gel.
Multimaterial Photodetecting Fibers: a Geometric and Structural Study (2007)

We report in this communication on structure property relations, specifically focusing on geometric scaling and its effect on the performance of one dimensional distributed photodetecting fibers. Envisioned applications include large area optoelectronic systems, remote sensing and multifunctional fabrics.
[Expressions and prognostic significance of PTEN and PD-1 protein in patients with classical Hodgkin's lymphoma]. (2018)

<b>Objective:</b> To elucidate the expression levels of key immune biomarkers, phosphate and tension homology deleted on chromosome ten (PTEN) and programmed cell death protein1(PD-1),of different immune tolerance pathway in classic Hodgkin's lymphoma (CHL) to further determine their clinical role and prognostic significance. <b>Methods:</b> The clinical features and prognostic factors of 56 CHL patients, who were admitted to the TianJin Medical University Cancer Institute from February 2003 to August 2013, were retrospectively analyzed. PTEN and PD-1 protein expression levels were analyzed by immunohistochemistry, Epstein-Barr virus encoded RNA (EBER) was performed by in situ hybridization assay. Correlations between the expression of biomarkers and clinicopathologic parameters were examined and survival analyses were performed. <b>Results:</b> This cohort of 56 CHL patients included 34 males and 22 females with a median age of 25 years (ranged from 7 to 71 years). In a univariate analysis, age≥45, IPS score >2, EBER positive, high expression of PTEN protein conferred inferior 5-year OS and 5-year PFS; In a multivariate model, age≥45, IPS score >2, EBER positive, high expression of PTEN protein were identified as the independent adverse prognostic factors for CHL. <b>Conclusions:</b> This study suggested for the first time that PTEN was independent prognostic immune biomarkers in CHL, which provided the novel therapeutic strategy of immune therapy for CHL.
The svninfo package (2010)

This package is used to extract the revision and le information provided by the Subversion (http://subversion.tigris.org) and the svk (http://svk.elixus.org) revision control system.
UV Damage and Repair in the Domain of the Human c–myc Oncogene (1991)

We have used a modification of the Southern hybridization method to analyze the removal of UV-induced pyrimidine cyclobutane dimers from the domain of the c-myc oncogene. The study was performed in human COLO320HSR cells, which exhibit a 30- to 40-fold amplification of c-myc that is maintained in a marker chromosome as a homogeneously staining region. Intron 2 and the region upstream from the gene showed better dimer removal than intron 1 or the region downstream from the c-myc gene. Regions showing less repair coincide with regions that are hotspots for mutations and chromosome translocations. Therefore, it is proposed that the inefficiency of DNA repair may play an important role in the origin of c-myc rearrangements.
Direct comparison of EUV and visible-light interferometries (1999)

Recent experiments with four 10x EUV imaging systems provide the first direct comparisons of visible-light and at- wavelength EUV interferometers performed using the state-of- the-art measurement tools that will be used to assemble and align the next generation of EUV imaging systems. Measurements from four individual multilayer-coated Schwarzschild objectives are discussed. Favorable agreement has been achieved between EUV and visible-light system wavefront measurements in all four optical systems. Measurements made in the presence of surface contamination and multilayer thickness variation, however, do show expected localized differences between the two measurements.
Data from Glioblastoma Stem Cells Are Regulated by Interleukin-8 Signaling in a Tumoral Perivascular Niche (2023)

&lt;div&gt;Abstract&lt;p&gt;Glioblastoma multiforme contains a subpopulation of cancer stem–like cells (CSC) believed to underlie tumorigenesis and therapeutic resistance. Recent studies have localized CSCs in this disease adjacent to endothelial cells (EC) in what has been termed a perivascular niche, spurring investigation into the role of EC–CSC interactions in glioblastoma multiforme pathobiology. However, these studies have been limited by a lack of &lt;i&gt;in vitro&lt;/i&gt; models of three-dimensional disease that can recapitulate the relevant conditions of the niche. In this study, we engineered a scaffold-based culture system enabling brain endothelial cells to form vascular networks. Using this system, we showed that vascular assembly induces CSC maintenance and growth &lt;i&gt;in vitro&lt;/i&gt; and accelerates tumor growth &lt;i&gt;in vivo&lt;/i&gt; through paracrine interleukin (IL)-8 signaling. Relative to conventional monolayers, endothelial cells cultured in this three-dimensional system not only secreted enhanced levels of IL-8 but also induced CSCs to upregulate the IL-8 cognate receptors CXCR1 and CXCR2, which collectively enhanced CSC migration, growth, and stemness properties. CXCR2 silencing in CSCs abolished the tumor-promoting effects of endothelial cells &lt;i&gt;in vivo&lt;/i&gt;, confirming a critical role for this signaling pathway in GMB pathogenesis. Together, our results reveal synergistic interactions between endothelial cells and CSCs that promote the malignant properties of CSCs in an IL-8–dependent manner. Furthermore, our findings underscore the relevance of tissue-engineered cell culture platforms to fully analyze signaling mechanisms in the tumor microenvironment. &lt;i&gt;Cancer Res; 73(23); 7079–89. ©2013 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Proposed BioRepository platform solution for the ALS research community (2010)

ALS is a rare disorder whose cause and pathogenesis is largely unknown ( 1 ). There is a recognized need to develop biomarkers for ALS to better understand the disease, expedite diagnosis and to facilitate therapy development. Collaboration is essential to obtain a sufficient number of samples to allow statistically meaningful studies. The availability of high quality biological specimens for research purposes requires the development of standardized methods for collection, long-term storage, retrieval and distribution of specimens. The value of biological samples to scientists and clinicians correlates with the completeness and relevance of phenotypical and clinical information associated with the samples ( 2 , 3 ). While developing a secure Web-based system to manage an inventory of multi-site BioRepositories, algorithms were implemented to facilitate ad hoc parametric searches across heterogeneous data sources that contain data from clinical trials and research studies. A flexible schema for a barcode label was introduced to allow association of samples to these data. The ALSBank™ BioRepository platform solution for managing biological samples and associated data is currently deployed by the Northeast ALS Consortium (NEALS). The NEALS Consortium and the Massachusetts General Hospital (MGH) Neurology Clinical Trials Unit (NCTU) support a network of multiple BioBanks, thus allowing researchers to take advantage of a larger specimen collection than they might have at an individual institution. Standard operating procedures are utilized at all collection sites to promote common practices for biological sample integrity, quality control and associated clinical data. Utilizing this platform, we have created one of the largest virtual collections of ALS-related specimens available to investigators studying ALS.