gebhart/patrepeval huggingface dataset:
Effect of balloon size and stepwise inflation technique on the acute results of inoue mitral commissurotomy (1993)

Currently percutaneous transvenous mitral commissurotomy (PTMC) is performed by most operators using stepwise inflation of the Inoue balloon beginning at a small diameter and increasing size by a sequence of inflations to nominal diameter. The effect of balloon size on procedure results using the Inoue balloon has not been evaluated. In 260 patients final balloon inflation was to nominal size in 42% of pts, larger than nominal size (overinflated) in 10%, and less than nominal size (underinflated) in 48% of pts. The average number of inflations was 3 (range 1-9). Pressure gradient and Doppler mitral regurgitation (MR) were assessed after each inflation. When MR increased, further inflations were not done. Patients in whom the balloon was overinflated underwent more balloon inflations than those in whom it was inflated to nominal size (5.0 +/- 2.1 vs. 2.9 +/- 1.4, p < 0.01). Those with balloon underinflation had fewer balloon inflations (2.4 +/- 1.2 vs. 2.9 +/- 1.4, p < 0.01). The post PTMC valve area in patients with overinflation was slightly less than those with nominal inflations (1.6 +/- 0.4 vs. 1.8 +/- 0.7), and with underinflation the valve area was no different compared to nominal inflation. Using a stepwise procedure, if mitral regurgitation was noted to increase after a balloon inflation, the procedure would be stopped even if less than an ideal result was achieved. Fewer inflations were done in patients in whom the balloon was inflated to less than nominal size because of the appearance of mitral regurgitation.(ABSTRACT TRUNCATED AT 250 WORDS)
A robot hand using electro-conjugate fluid: Imitating a palm motion of human hand using soft balloon actuator (2011)

An electro-conjugate fluid (ECF) is a kind of functional fluid, which produces a jet flow (ECF jet) when subjected to high DC voltage. It is known that a strong ECF jet is generated under nonuniform electric field, for example, the field with a pair of needle and ring electrodes. We developed in our previous study a novel five-fingered flexible robot hand using the ECF. In this study, in order to improve the ECF hand we pay our attention to the flexion of palm because human hand can grasp an object with the flexion of palm. First, we propose a concept of five fingered robot hand which has balloon actuators driven by ECF jet to produce the flexion of palm. The actuator is mainly composed of silicone rubber membrane and a rubber base with a slit, so that when the actuator is pressurized the slit is opened, resulting in making the palm of the robot hand actuate. When the actuator is pressurized with 20 kPa the rubber slit is opened with approximately 60 deg. Finally we investigate the characteristics of the actuator and introduce it into the ECF robot hand.
Preface (2010)

Twenty years ago, only a handful of laboratories, some in industry and some in academia, were interested in using enzyme-catalysed reactions (biotransformations) in organic synthesis. At best those researchers were considered to be at the margin of mainstream synthetic organic chemistry; at worst they were considered to be downright odd.
A Knowledge Representation Framework in Design Repository (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Online transfer learning for differential diagnosis determination (2015)

In this paper we present a novel online transfer learning approach to determine the set of tests to perform, and the sequence in which they need to be performed, in order to develop an accurate diagnosis while minimizing the cost of performing the tests. Our learning approach can be incorporated as part of a clinical decision support system (CDSS) with which clinicians can interact. The approach builds on a contextual bandit framework and uses online transfer learning to overcome limitations with the availability of rich training data sets that capture different conditions, context, test results as well as outcomes. We provide confidence bounds for our recommended policies, which is essential in order to build the trust of clinicians. We evaluate the algorithm against different transfer learning approaches on real-world patient alarm datasets collected from Neurological Intensive Care Units (with reduced costs by 20%).
Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling. (1998)

Membrane glycoprotein PC-1 inhibits insulin receptor (IR) tyrosine kinase activity and subsequent cellular signaling. PC-1 content is elevated in muscle and adipose tissue from insulin-resistant subjects, and its elevation correlates with in vivo insulin resistance. To determine whether elevated PC-1 content is a primary cause of insulin resistance, we have now measured PC-1 content in cultured skin fibroblasts from nonobese nondiabetic insulin-resistant subjects and found that 1) PC-1 content was significantly higher in these cells when compared with cells from insulin-sensitive subjects (6.7 +/- 0.9 vs. 3.1 +/- 0.6 ng/0.1 mg protein, mean +/- SE, P < 0.01); 2) PC-1 content in fibroblasts was highly correlated with PC-1 content in muscle tissue (r = 0.95, P = 0.01); 3) PC-1 content in fibroblasts negatively correlated with both decreased in vivo insulin sensitivity and decreased in vitro IR autophosphorylation; and 4) in cells from insulin-resistant subjects, insulin stimulation of glycogen synthetase was decreased. These studies indicate, therefore, that the elevation of PC-1 content may be a primary factor in the cause of insulin resistance.
Use of Spin Echo Magic Angle Spinning 1H NMR in Reaction Monitoring in Combinatorial Organic Synthesis (1996)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTUse of Spin Echo Magic Angle Spinning 1H NMR in Reaction Monitoring in Combinatorial Organic SynthesisRavi S. Garigipati, Bruce Adams, Jerry L. Adams, and Susanta K. SarkarView Author Information Departments of Medicinal Chemistry and Physical and Structural Chemistry, SmithKline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, and Varian Instruments, 25 Hanover Road, Florham Park, New Jersey 07932 Cite this: J. Org. Chem. 1996, 61, 8, 2911–2914Publication Date (Web):April 19, 1996Publication History Received4 December 1995Published online19 April 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jo952153ohttps://doi.org/10.1021/jo952153obrief-reportACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views243Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aromatic compounds,Hydrocarbons,Nuclear magnetic resonance spectroscopy,Organic polymers,Quantum mechanics Get e-Alerts
A New Photocaging Group for Aromatic N‐Heterocycles. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Strain-Induced Modulation of Resistive Switching Temperature in Epitaxial VO2 Thin Films on Flexible Synthetic Mica (2022)

The resistive switching temperature associated with the metal-insulator transition (MIT) of epitaxial VO<sub>2</sub> thin films grown on flexible synthetic mica was modulated by bending stress. The resistive switching temperature of polycrystalline VO<sub>2</sub> and V<sub>2</sub>O<sub>5</sub> thin films, initially grown on synthetic mica without a buffer layer, was observed not to shift with bending stress. By inserting a SnO<sub>2</sub> buffer layer, epitaxial growth of the VO<sub>2</sub> (010) thin film was achieved, and the MIT temperature was found to vary with the bending stress. Thus, it was revealed that the bending response of the VO<sub>2</sub> thin film depends on the presence or absence of the SnO<sub>2</sub> buffer layer. The bending stress applied a maximum in-plane tensile strain of 0.077%, resulting in a high-temperature shift of 2.3 °C during heating and 1.8 °C during cooling. After 10<sup>4</sup> bending cycles at a radius of curvature <i>R</i> = 10 mm, it was demonstrated that the epitaxial VO<sub>2</sub> thin film exhibits resistive switching temperature associated with MIT.
Single cell label-free probing of chromatin dynamics during B lymphocyte maturation (2021)

ABSTRACT Large-scale intracellular signalling during developmental growth or in response to environmental alterations are largely orchestrated by chromatin within the cell nuclei. Chemical and conformational modifications of the chromatin architecture are critical steps in the regulation of differential gene expression and ultimately cell fate determination. Therefore, establishing chemical properties of the nucleus could provide key markers for phenotypic characterisation of cellular processes on a scale of individual cells. Raman microscopy is a sensitive technique that is capable of probing single cell chemical composition - and sub-cellular regions - in a label-free optical manner. As such, it has great potential in both clinical and basic research. However, perceived limitations of Raman spectroscopy such as low signal intensity and the difficulty in linking alterations in vibrational signals directly with ensuing biological effects have hampered advances in the field. Here we use immune B lymphocyte development as a model to assess chromatin and transcriptional changes using confocal Raman microscopy in combination with microfluidic devices and correlative transcriptomics, thereby linking changes in chemical and structural properties to biological outcomes. Live B lymphocytes were assessed before and after maturation. Multivariate analysis was applied to distinguish cellular components within each cell. The spectral differences between non-activated and activated B lymphocytes were then identified, and their correlation with known intracellular biological changes were assessed in comparison to conventional RNA-seq analysis. Our data shows that spectral analysis provides a powerful tool to study gene activation that can complement conventional molecular biology techniques and opens the way for mapping the dynamics in the biochemical makeup of individual cells.
Asymmetrical Cylindrical Dual‐Mode Waveguide Filters with Transmission Zeros (2007)

This chapter contains sections titled: Introduction Dual-Mode Cylindrical Waveguide Filters Synthesis of Low-Pass Asymmetrical Generalized Chebyshev Filters Design Method Realizations and Measured Performance Conclusions References
Effect of heating on the optical loss in the As-Se glass fiber (2003)

The increase in the optical loss of the IR-transmitting arsenic-selenide glass fiber in the temperature range of 150°C /spl ges/T/spl ges/ 20°C was investigated. Between the wavelength region of 1.3 and 8 μm, there is a small increase in the loss in which the contribution of free-carrier absorption is small. At high temperature T=150°C and /spl lambda//spl ges/8 μm, both the free-carrier and multiphonon absorption contributed to the total loss. From a practical perspective, the As-Se fiber loss increases only slightly under normal operating temperatures and so can still be used for many applications.
Characterization of the Circadian System of NGFI-A and NGFI-A/NGFI-B Deficient Mice (1998)

The genes NGFI-A (also known as EGR-1, zif/268, and Krox-24) and NGFI-B (nur/77) have previously been shown to be induced in the SCN of rats and hamsters by photic stimulation during the subjective night. The purpose of this study is to determine whether these genes are also induced in the SCN of mice and, if so, to characterize the circadian system of animals in which either NGFI-A or both NGFI-A and NGFI-B were eliminated by homologous recombination. In wildtype mice, NGFI-A mRNA was found to be induced in the SCN as in other rodent species. Therefore, wheel-running activity was recorded from null mutants and wildtype controls under LD 12:12 and DD conditions. Mice of all three strains appeared to entrain normally to LD 12:12 and could re-entrain to both phase advances and phase delays of the light cycle. The response of the circadian pacemaker of all three genotypes to acute light pulses appeared to be normal. The retinal innervation of the SCN in NGFI-A-/- mice and the photic induction of Fos in the SCN of both NGFI-A-/- and NGFI-A-/-/B-/- mice were indistinguishable from wildtype mice. These results indicate that induction of NGFI-A and NGFI-B is not required for photic entrainment or phase shifting of the mouse circadian system.
Fabrication of SiCN MEMS structures using microforged molds (2002)

Ceramics and polymers are becoming attractive candidate materials for MEMS applications because of the wide range of properties that can be obtained and the promise of improved performance as compared to the existing materials set for MEMS. A challenge in the fabrication of ceramic MEMS is prohibiting cracking that can occur during processing. For example, this is significant in the development of a microcasting fabrication technique from a polymer precursor for silicon carbonitride (SiCN) MEMS. In this case, shrinkage mismatch between the SiCN structure and the microfabricated mold during thermal processes leads to significant stresses that can crack the ceramic structure. Here we propose an approach to overcome this problem that relies on demolding prior to the large shrinkage mismatch thermal processes, which itself is a nontrivial challenge. To this end, we propose a microforging process that facilitates demolding. We describe the process and show representative results for numerous SiCN ceramic microstructures.
Non-histone nuclear factor HMGB1 is phosphorylated and secreted in colon cancers (2009)

The high mobility group box 1 (HMGB1) protein, a non-histone nuclear factor, is overexpressed and localizes to the cytoplasm in some cancer cells. However, the mechanism of cytoplasmic HMGB1 transport, extracellular secretion, and its role in cancer progression is not clear. To simulate the activated state of HMGB1, we mutated serine residues of nuclear localization signals (NLSs) to glutamic acid and performed transfection assays. We carried out a kinase inhibitor study and evaluated the cell migration by invasion assay. We showed that phosphorylated HMGB1 localizes in the cytoplasm of colon cancer cells and also showed the interaction of PKC and HMGB1 by immunoprecipitation analysis. Concurrent mutations at six serine residues (35, 39, 42, 46, 53, and 181) to glutamic acid induced the nuclear to cytoplasmic transport of HMGB1, which was detected in the culture medium. We also observed that the secretion of HMGB1 correlated with increased cancer cell invasiveness. Our results suggest that phosphorylated HMGB1 is transported to the cytoplasm, is subsequently secreted from the cell, and has a role in tumor progression through the activation of genes related to cell migration.
Localized and distributed erosion triggered by the 2015 Hurricane Patricia investigated by repeated drone surveys and time lapse cameras at Volcán de Colima, Mexico (2018)

In October 2015, Patricia, a major category 5 hurricane, made landfall in western Mexico, resulting in 500 mm cumulated rainfall and lahar generation along the southerly directed Montegrande valley of Volcán de Colima. We monitored lahar deposition and erosion using time-lapse trail cameras and conducted repeated camera drone overflights, two days before and after the hurricane. Using photogrammetric processing we derive a unique dataset of high resolution digital terrain models and study the geomorphologic impacts of a single lahar event. Results reveal different types of erosion at 8 km distance from the volcano, with overland flow and rill networks, developing into major erosion gullies exceeding a depth of 4 m, as well as bank collapse, oversteepening and marginal erosion. We find alternating deposition and erosion zones that depend on general slope and valley width, and find that the overland flow related erosion is an important contributor to the bulking process of lahars. Moreover, this study shows that camera monitoring is very useful for studying the relationship between volcano landscape evolution and hydrometeorological extremes and for rapid assessment associated with single lahar events.
Protection against Divergent Influenza H1N1 Virus by a Centralized Influenza Hemagglutinin (2011)

Influenza poses a persistent worldwide threat to the human population. As evidenced by the 2009 H1N1 pandemic, current vaccine technologies are unable to respond rapidly to this constantly diverging pathogen. We tested the utility of adenovirus (Ad) vaccines expressing centralized consensus influenza antigens. Ad vaccines were produced within 2 months and protected against influenza in mice within 3 days of vaccination. Ad vaccines were able to protect at doses as low as 10(7) virus particles/kg indicating that approximately 1,000 human doses could be rapidly generated from standard Ad preparations. To generate broadly cross-reactive immune responses, centralized consensus antigens were constructed against H1 influenza and against H1 through H5 influenza. Twenty full-length H1 HA sequences representing the main branches of the H1 HA phylogenetic tree were used to create a synthetic centralized gene, HA1-con. HA1-con minimizes the degree of sequence dissimilarity between the vaccine and existing circulating viruses. The centralized H1 gene, HA1-con, induced stronger immune responses and better protection against mismatched virus challenges as compared to two wildtype H1 genes. HA1-con protected against three genetically diverse lethal influenza challenges. When mice were challenged with 1934 influenza A/PR/8/34, HA1-con protected 100% of mice while vaccine generated from 2009 A/TX/05/09 only protected 40%. Vaccination with 1934 A/PR/8/34 and 2009 A/TX/05/09 protected 60% and 20% against 1947 influenza A/FM/1/47, respectively, whereas 80% of mice vaccinated with HA1-con were protected. Notably, 80% of mice challenged with 2009 swine flu isolate A/California/4/09 were protected by HA1-con vaccination. These data show that HA1-con in Ad has potential as a rapid and universal vaccine for H1N1 influenza viruses.
Clinical and genetic characterization of pituitary gigantism: an international collaborative study in 208 patients (2015)

Despite being a classical growth disorder, pituitary gigantism has not been studied previously in a standardized way. We performed a retrospective, multicenter, international study to characterize a large series of pituitary gigantism patients. We included 208 patients (163 males; 78.4%) with growth hormone excess and a current/previous abnormal growth velocity for age or final height >2 s.d. above country normal means. The median onset of rapid growth was 13 years and occurred significantly earlier in females than in males; pituitary adenomas were diagnosed earlier in females than males (15.8 vs 21.5 years respectively). Adenomas were ≥10 mm (i.e., macroadenomas) in 84%, of which extrasellar extension occurred in 77% and invasion in 54%. GH/IGF1 control was achieved in 39% during long-term follow-up. Final height was greater in younger onset patients, with larger tumors and higher GH levels. Later disease control was associated with a greater difference from mid-parental height (r=0.23, P=0.02). AIP mutations occurred in 29%; microduplication at Xq26.3 - X-linked acrogigantism (X-LAG) - occurred in two familial isolated pituitary adenoma kindreds and in ten sporadic patients. Tumor size was not different in X-LAG, AIP mutated and genetically negative patient groups. AIP-mutated and X-LAG patients were significantly younger at onset and diagnosis, but disease control was worse in genetically negative cases. Pituitary gigantism patients are characterized by male predominance and large tumors that are difficult to control. Treatment delay increases final height and symptom burden. AIP mutations and X-LAG explain many cases, but no genetic etiology is seen in >50% of cases.
Electronic structures of hexacyanometalate complexes (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic structures of hexacyanometalate complexesJohn J. Alexander and Harry B. GrayCite this: J. Am. Chem. Soc. 1968, 90, 16, 4260–4271Publication Date (Print):July 1, 1968Publication History Published online1 May 2002Published inissue 1 July 1968https://pubs.acs.org/doi/10.1021/ja01018a013https://doi.org/10.1021/ja01018a013research-articleACS PublicationsRequest reuse permissionsArticle Views1997Altmetric-Citations268LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts