gebhart/patrepeval huggingface dataset:
Interfacial reaction and its effect on strength of Al18B4O33/Al composites (1999)

Aluminium alloy 6061, AC8A, Al–1Mg, Al–9Cu and pure aluminium composites reinforced with aluminium borate whiskers were fabricated by a squeeze casting process. The interfacial reaction in the composites and its effect on the bending strength are discussed, together with the results from SEM, TEM, and X-ray diffraction. A slight interfacial reaction is favourable for composite strength as it has the effect of anchoring the whiskers. A T6 treatment can enhance the strength of an Al–9Cu matrix composite, but is not efficient for magnesium containing 6061 and AC8A matrix composites. Furthermore, if heated at temperatures higher than 793 K for a long time, the composite strength drops rapidly owing to whisker damage and shortening during the interfacial reaction. It is suggested that the interface in an Al18 B4O33 /Al alloy composite is stable below 623 K which is the temperature requirement for automobile engine components.
Spine Care: Evaluation of the Efficacy and Cost of Emerging Technology (2009)

Over the last decade a number of new technologies have been introduced to the area of spine care. Although this recent explosion of innovation has brought advances to patient care, it has also brought concerns regarding overuse, increasing costs, and safety. A value-based approach to assessing and purchasing new technology depends on a shift toward comparative effectiveness analysis, transparency in pricing and potential conflicts of interest, and an alignment of incentives and goals among purchasers, consumers, and payers. How to assess the effectiveness of new technology in patient care is an unresolved issue for any cost-effectiveness analysis, as models traditionally used to assess medical therapies (ie, quality-adjusted life years) may not be directly applicable to analysis of surgical intervention. Spine surgeons must be involved in multidisciplinary collaborative efforts to develop models of efficacy analysis and to direct outcomes-based research to appropriately evaluate the benefits of surgical interventions and new technologies.
Computation-Based Discovery of Related Transcriptional Regulatory Modules and Motifs Using an Experimentally Validated Combinatorial Model (2002)

Gene expression is regulated by transcription factors that interact with cis-regulatory elements. Predicting these elements from sequence data has proven difficult. We describe here a successful computational search for elements that direct expression in a particular temporal-spatial pattern in the Drosophila embryo, based on a single well characterized enhancer model. The fly genome was searched to identify sequence elements containing the same combination of transcription factors as those found in the model. Experimental evaluation of the search results demonstrates that our method can correctly predict regulatory elements and highlights the importance of functional testing as a means of identifying false-positive results. We also show that the search results enable the identification of additional relevant sequence motifs whose functions can be empirically validated. This approach, combined with gene expression and phylogenetic sequence data, allows for genome-wide identification of related regulatory elements, an important step toward understanding the genetic regulatory networks involved in development.
A New AdvancedMRIBiomarker for Remyelinated Lesions in Multiple Sclerosis (2022)

These results provide the first evidence that it is possible to distinguish chronic MS lesions in a clinical setting, hereby supporting with new biomarkers to develop and assess remyelinating treatments. ANN NEUROL 2022;92:486-502.
Trans-Atlantic Field Trial Using High Spectral Efficiency Probabilistically Shaped 64-QAM and Single-Carrier Real-Time 250-Gb/s 16-QAM (2017)

We report the transmission of probabilistically shaped (PS) 64-ary quadrature amplitude modulation (QAM) at 7.46 b/s/Hz over a 5523-km in-service trans-Atlantic fiber-optic cable that consists of 65-89-km spans of Erbium-doped fiber amplifier only amplified fiber. Using a looped-back system configuration, we achieve 5.68 b/s/Hz over a trans-Pacific-equivalent distance of 11 046 km. Net spectral efficiencies are increased by 18% and 80% by using PS, at 5523 km and 11 046 km, respectively, compared to uniform square QAM. Throughout our experiments, we pay particular attention that our claims are backed by implementable forward error correction schemes. In addition, we demonstrate real-time coherent transmission of single-carrier 200 and 250-Gb/s uniform 8-QAM and 16-QAM at 4 b/s/Hz over the 5523-km cable.
Efficient Barriers for Persistent Object Caching in a High-Performance Java TM Virtual Machine (1999)

We implemented orthogonal persistence for the Java platform by adding persistent object caching to a high-performance virtual machine that uses exact garbage collection ##EVM&amp;quot;# 1 . This paper gives an overview of our design for the read and write barriers needed to support persistence. The key design decision we made was the choice of a pointer swizzling strategy.Pointer swizzling speeds up programs by translating persistent addresses #references to persistent objects on disk# into normal virtual memory addresses in the object cache. The swizzling technique wechose is simple #requires few source changes to the EVM# and performs well #adds acceptably low CPU overhead to the EVM#. Our integration of the new barriers was considerably simpli#ed byaninternal memory interface that the EVM consistently uses, except in its JIT, to access program runtime values. Our new persistentversion of the EVM, the PEVM, requires just 30# of the changes necessary in our previous persistent virtual machin...
Electron scattering near an itinerant to localized electronic transition (2003)

We report an unconventional temperature dependence of the resistivity in several strongly correlated systems approaching a localized to itinerant electronic transition from the itinerant electron side. The observed $(\ensuremath{\rho}\ensuremath{-}{\ensuremath{\rho}}_{0})\ensuremath{\propto}{T}^{3/2}$ behavior over the entire range of materials discussed cannot be explained within the framework of existing theories. We propose a model in which the scattering of the conduction electrons by locally cooperative bond-length fluctuations in a matrix of vibronic and Fermi-liquid electrons can account for the experimental data.
Comment on Lack of Effect of Raloxifene on Coronary Artery Atherosclerosis of Postmenopausal Monkeys (1998)

Recently, Fuller et al. (1) reported the absence of mutations in the FSH-receptor in granulosa cell tumors.These findings differed from our previous study (2), which described a Phe-to-Ser mutation in codon 591 (F591S) in the 6th transmembrane domain of the FSH-receptor in approximately two thirds of sex cord tumors, including granulosa cell tumors.Because of the discrepancy in these two studies, we analyzed additional samples of granulosa cell tumors and reanalyzed the original samples reported in our study.In our analyses of ten new specimens of granulosa cell tumors, we found that none of the new specimens had the F591S mutation.However, when we reanalyzed the DNA samples reported in our earlier study (2), the results were confirmed as originally reported.Although the F591S mutation had been confirmed multiple times and using several independent techniques, including direct DNA sequencing, oligonucleotide specific hybridization, and mutationspecific digestion with restriction endonucleases, we remained skeptical in view of our results with new specimens and in view of the findings of other groups.Therefore, all of the original paraffin blocks were reextracted, DNA was isolated, and the sequence analyses were repeated.In this case, we did not find the F591S mutation in any of the specimens.Although there are several possible explanations, contamination during the initial paraffin extraction or DNA isolation process is most likely.The source of DNA contamination remains elusive and was difficult to recognize because direct sequencing resulted in a characteristic heterozygous mutation pattern (2).Although there was no evidence of contamination in any of the more than 100 controls that were run during the sequence analyses, we did not anticipate the possibility that the original DNA specimens might be contaminated.Care was taken, for example, to use new blades for the sectioning of each specimen.How contamination occurred and the source of the contaminant remain unknown.To our knowledge, no plasmid with this sequence ever existed in the laboratory at the time of the DNA isolation.It is also unknown why the contamination affected only some of the samples.Taken together, these analyses suggest that the F591S mutation that we identified originally was due to contamination that occurred during the handling of the paraffin blocks or during DNA isolation.Contamination did not occur during the PCR analyses for mutation detectionthe step at which controls are typically introduced.In addition to the implications for our own study, this problem underscores the potential difficulties associated with mutation detection by PCR.In retrospect, this erroneous detection of the F591S mutation explains its unusual functional effects and its occurrence in tumor types with disparate histological classifications.The F591S substitution inactivated the FSHreceptor rather than causing constitutive activation as occurs with activating mutations of the TSH-receptor or the LH receptor.We regret any confusion that this error has caused.
Association of carotid intima-media thickness with cardiovascular risk factors and patient outcomes in advanced chronic kidney disease: the RRI-CKD study (2015)

In patients with advanced pre-dialysis CKD, higher maximum IMT was associated with traditional cardiovascular risk factors, CVD, and other markers of subclinical CVD and as an independent predictor of cardiovascular events and death. Additional research is needed to examine the clinical utility of IMT in the risk stratification and clinical management of patients with CKD.
A novel non-linguistic audio-visual learning paradigm to test the cognitive correlates of learning rate (2021)

Audio‐visual (AV) associative learning is central to many aspects of cognitive development and is key in reading acquisition. Most studies thus far have examined AV associative learning involving linguistic stimuli. Yet it is of importance to examine cross-modal learning free of familiarity confounds. We, therefore, designed an AV learning paradigm relying on novel, non-linguistic auditory and visual stimuli, which were both unfamiliar to participants. On top of AV learning, we collected performance in reading-related abilities, as well as in more domain-general skills, in a population of healthy Italian-speaking adults (N=57). By fitting trial-by-trial performance in our novel learning task, we demonstrate the expected variability in speed of learning (learning rate) across participants. We then show that speed of learning in our novel learning task is positively associated with working memory and replicate this result in a set of French-speaking participants (N=32), showing that it holds in another language.
Serum antibodies in young adult humans reactive with periodontitis associated treponemes (1985)

The present study was undertaken to determine whether young adults with generalized severe periodontitis (SP) or the more localized juvenile periodontitis (JP) have serum antibody reactive with a panel of periodontitis associated treponemes more frequently or at higher titer than a group of young adults with a healthy periodontium (HP). The human subjects consisted of 52 SPs, 47 JPs, and 52 HPs. The panel of treponemes included three strains of Treponema denticola and several strains of newly described treponemes, Treponema socranskii ss. socranskii, Treponema socranskii ss. buccale , and Treponema socranskii ss. paredis . The frequency and magnitude of serum antibody titers were determined using a sensitive radioimmunoassay. Subjects with JP were more frequently seropositive than were HP subjects to several strains of the treponemes tested (p&lt;0.01 for Treponema socranskii ss. buccale [D40PE2], Treponema denticola [D3A9], and Treponema socranskii ss. paredis [D28C3]). However, the most surprising result was the low level and frequent lack of antibody in SP sera reactive with these periodontitis‐associated treponemes. Excluding data where only two points above the cut off were required for seropositivity, neither the frequency of seropositivity nor the magnitude of antibody titers of SP subjects exceeded those respective values for HP subjects. The frequency of seropositivity in SP subjects to T. socranskii ss. socranskii (D43BR1) was significantly depressed as compared to HP subjects (p&lt;0.01). In short, it appeared that SP subjects either failed to mount a significant anti‐treponemal antibody response or those responses were specifically suppressed.
ChemInform Abstract: Diethoxymethyl Protected Pyrroles: Synthesis and Regioselective Transformations. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mild base-promoted conversion of tertiary cis,cis-2,4-cyclononadienols to bicyclo[4.3.1]nona-2,4-dienes. Antarafacial cyclization of coiled 8.pi.-7C conjugated anions (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMild base-promoted conversion of tertiary cis,cis-2,4-cyclononadienols to bicyclo[4.3.1]nona-2,4-dienes. Antarafacial cyclization of coiled 8.pi.-7C conjugated anionsLeo A. Paquette and Gary D. CrouseCite this: J. Am. Chem. Soc. 1981, 103, 20, 6235–6236Publication Date (Print):October 1, 1981Publication History Published online1 May 2002Published inissue 1 October 1981https://doi.org/10.1021/ja00410a052RIGHTS & PERMISSIONSArticle Views92Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (294 KB) Get e-Alerts Get e-Alerts
On the time-frequency localisation of 5G candidate waveforms (2015)

Among the requirements of the 5th generation (5G) radio access technology (RAT) is that the associated waveform be well-localised in time and frequency. Localisation characteristics of waveforms are important when considering multiplexing and duplexing of transmissions. This paper proposes a measure of time-frequency localisation (TFL) for sets of orthogonal waveforms, based on Heisenberg's well-known Uncertainty Principle, allowing for the containment of OFDM and FBMC multicarrier signals over the entire bandwidth to be determined. A theoretical bound on TFL for sets of orthogonal waveforms sharper than the general uncertainty principle is provided. Several multicarrier waveforms generated using well-defined filters are shown by simulation to approach the derived bound as the number of subcarriers increases.
iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson’s Disease (2014)

Parkinson's disease (PD) has been attributed to a combination of genetic and nongenetic factors. We studied a set of monozygotic twins harboring the heterozygous glucocerebrosidase mutation (GBA N370S) but clinically discordant for PD. We applied induced pluripotent stem cell (iPSC) technology for PD disease modeling using the twins' fibroblasts to evaluate and dissect the genetic and nongenetic contributions. Utilizing fluorescence-activated cell sorting, we obtained a homogenous population of "footprint-free" iPSC-derived midbrain dopaminergic (mDA) neurons. The mDA neurons from both twins had ∼50% GBA enzymatic activity, ∼3-fold elevated α-synuclein protein levels, and a reduced capacity to synthesize and release dopamine. Interestingly, the affected twin's neurons showed an even lower dopamine level, increased monoamine oxidase B (MAO-B) expression, and impaired intrinsic network activity. Overexpression of wild-type GBA and treatment with MAO-B inhibitors normalized α-synuclein and dopamine levels, suggesting a combination therapy for the affected twin.
Natural history and clinical outcomes of inappropriate sinus tachycardia (2019)

In our study cohort, IST predominately affects young females with structurally normal hearts and modest coexistent psychiatric disease. In most cases of IST, a major event occurring just before or at the time of diagnosis could not be identified, although nearly 8% of patients first noted symptoms during or shortly after pregnancy. In our cohort, there was no evidence of cardiomyopathy or mortality related to IST.
Absorption Spectroscopy and Imaging from the Visible through Mid-Infrared with 20 nm Resolution (2015)

Absorption spectroscopy and mapping from visible through mid-IR wavelengths has been achieved with spatial resolution exceeding the limit imposed by diffraction via the photothermal induced resonance technique. Correlated vibrational (chemical), and electronic properties are obtained simultaneously with topography with a wavelength-independent resolution of ≈20 nm using a single laboratory-scale instrument. This marks the highest resolution reported for PTIR, as determined by comparing height and PTIR images, and its first extension to near-IR and visible wavelengths.
People With Disabilities: An Update (1989)

An update of information presented in the original article (Fagan &amp; Wallace, 1979), this article provides more recent figures on handicapping conditions in school‐age and adult populations. The title and language usage have been changed to reflect current understanding of the connection between descriptive language and attitudes toward people with disabilities. Changes in federal legislation, interpretations, and their impact are presented. To complement the original article, the update focuses more heavily on adult handicapping conditions and rehabilitation services.
A Fully Integrated 3.3–3.8-GHz Power Amplifier With Autotransformer Balun (2009)

This paper demonstrates the usage of a differential autotransformer as an output balun for an integrated power amplifier (PA) operating at low-gigahertz frequencies. In comparison with a conventional transformer balun, an autotransformer balun offers lower power losses, thereby increasing the saturated output power and reducing the gain compression at the edge of target power range. A theoretical analysis of an integrated autotransformer is given, comparison with a magnetic transformer is performed. The concept was experimentally verified in a fully integrated PA for a 3.3-3.8-GHz WiMAX band fabricated in SiGe : C bipolar technology. The active part of the amplifier implements the derivative superposition method aimed at linearizing the power transfer characteristic. Measured PA delivers saturated output power above 29 dBm. The maximum achieved power-added efficiency exceeds 40% at 3.4 GHz. At 3.5 GHz, 1-dB gain compression occurs for <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">P</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">out</sub> = 24.6 dBm.
Spectral Embedding of Graph Networks (2020)

We introduce an unsupervised graph embedding that trades off local node similarity and connectivity, and global structure. The embedding is based on a generalized graph Laplacian, whose eigenvectors compactly capture both network structure and neighborhood proximity in a single representation. The key idea is to transform the given graph into one whose weights measure the centrality of an edge by the fraction of the number of shortest paths that pass through that edge, and employ its spectral proprieties in the representation. Testing the resulting graph network representation shows significant improvement over the sate of the art in data analysis tasks including social networks and material science. We also test our method on node classification from the human-SARS CoV-2 protein-protein interactome.
Cerium Oxide Nanoparticles Sensitize Pancreatic Cancer to Radiation Therapy through Oxidative Activation of the JNK Apoptotic Pathway (2018)

Side effects of radiation therapy (RT) remain the most challenging issue for pancreatic cancer treatment. Cerium oxide nanoparticles (CONPs) are currently being tested in pre-clinical trials as an adjuvant to sensitize pancreatic cancer cells to RT and protect normal tissues from the harmful side effects. CONPs were not able to significantly affect RT-induced DNA damage in cancer cells, thereby ruling out sensitization through increased mitotic catastrophe. However, activation of c-Jun terminal kinase (JNK), a key driver of RT-induced apoptosis, was significantly enhanced by co-treatment with CONPs and RT in pancreatic cancer cells in vitro and human pancreatic tumors in nude mice in vivo compared to CONPs or RT treatment alone. Further, CONP-driven increase in RT-induced JNK activity was associated with a marked increase in Caspase 3/7 activation, indicative of apoptosis. We have previously shown that CONPs increase reactive oxygen species (ROS) production in cancer cells. ROS has been shown to drive the oxidation of thioredoxin 1 (TRX1) which results in the activation of apoptosis signaling kinase 1 (ASK1). The increase in ASK1 activation following the co-treatment with CONPs followed by RT suggests that the increased JNK activation is the result of increased TRX1 oxidation. The ability of CONPs to sensitize pancreatic cancer cells to RT was mitigated when the TRX1 oxidation was prevented by mutagenesis of a cysteine residue or when the JNK activation was blocked by an inhibitor. Taken together, these data demonstrate an important mechanism for CONPs in specifically killing cancer cells and provide novel insights into the utilization of CONPs as a radiosensitizer and therapeutic agent for pancreatic cancer.