gebhart/patrepeval huggingface dataset:
Allergen-Specific Antibodies Regulate Secondary Allergen-Specific Immune Responses (2019)

Immunoglobulin E (IgE)-associated allergy is the most common immunologically-mediated hypersensensitivity disease. It is based on the production of IgE antibodies and T cell responses against <i>per se</i> innocuous antigens (i.e., allergens) and subsequent allergen-induced inflammation in genetically pre-disposed individuals. While allergen exposure in sensitized subjects mainly boosts IgE production and T cell activation, successful allergen-specific immunotherapy (AIT) induces the production of allergen-specific IgG antibodies and reduces T cell activity. Under both circumstances, the resulting allergen-antibody complexes play a major role in modulating secondary allergen-specific immune responses: Allergen-IgE complexes induce mast cell and basophil activation and perpetuate allergen-specific T cell responses via presentation of allergen by allergen presenting cells to T cells, a process called IgE-facilitated antigen presentation (FAP). In addition, they may induce activation of IgE memory B cells. Allergen-induced production of specific IgGs usually exerts ameliorating effects but under certain circumstances may also contribute to exacerbation. Allergen-specific IgG antibodies induced by AIT which compete with IgE for allergen binding (i.e., blocking IgG) inhibit formation of IgE-allergen complexes and reduce activation of effector cells, B cells and indirectly T cells as FAP is prevented. Experimental data provide evidence that by binding of allergen-specific IgG to epitopes different from those recognized by IgE, allergen-specific IgG may enhance IgE-mediated activation of mast cells, basophils and allergen-specific IgE<sup>+</sup> B cells. In this review we provide an overview about the role of allergen-specific antibodies in regulating secondary allergen-specific immune responses.
Lack of evidence to support present medial release methods in total knee arthroplasty (2014)

V (expert opinion).
Ester oxide intermediates in the ozonolysis of cyclic vinyl ethers (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEster oxide intermediates in the ozonolysis of cyclic vinyl ethersWilliam H. BunnelleCite this: J. Am. Chem. Soc. 1989, 111, 19, 7613–7614Publication Date (Print):September 1, 1989Publication History Published online1 May 2002Published inissue 1 September 1989https://pubs.acs.org/doi/10.1021/ja00201a052https://doi.org/10.1021/ja00201a052research-articleACS PublicationsRequest reuse permissionsArticle Views146Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pr-Based Nanofiber Cathode for Intermediate Temperature SOFCs (2021)

In this work, praseodymium based double perovskite (PrBa0.5Sr0.5Co1.5Fe0.5O5+𝛿) - PBSCF nanofibers cathodes were fabricated by electrospinning technique for intermediate-temperature solid oxide fuel cells (IT-SOFCs).The optimized three-dimensional nanofiber network cathode provides high porosity coupled with the higher interfacial contact area, leading to a faster oxygen reduction reaction (ORR) kinetics. EIS analysis of the nanofiber structured cathode resulted in a polarization resistance of ~0.025 Ω cm 2 at 750 °C. Resulted low resistance is smaller than the commercial LSCF cathode showing polarization resistance of ~0.041 Ω cm 2 at 750 °C. The peak power densities of the PBSCF fibers are ~2539, 1580 and 993 mW/ cm 2 at 750, 700, and 650 °C, respectively when compared to LSCF cathode performance of ~ 1974, 1304 and 769 mW/ cm 2 at same temperature. Such promising performance of fiber cathode IT-SOFCs in this study was achieved via careful selection of the catalyst structure and composition, electrode structure for efficient ORR, and perhaps through process optimizations. The results obtained in this study illustrates that one-dimensional nanostructures obtained by adopting nanofibers can be an appropriate cathode material choice for intermediate-temperature SOFCs suitable for automotive applications.
Novel Ti:LiNbO3 Polarization Converter with a Reversed-Electrode (2009)

We have successfully fabricated a polarization converter by reversing the polarity of the electrode in coherence length along a X-cut Z-propagating Ti:LiNbO3 waveguide. 100% conversion ratio was achieved with an applied voltage of 17 V.
Adaptation of β-cell mass to substrate oversupply: enhanced function with normal gene expression (2001)

Although type 2 diabetes mellitus is associated with insulin resistance, many individuals compensate by increasing insulin secretion. Putative mechanisms underlying this compensation were assessed in the present study by use of 4-day glucose (GLC; 35% Glc, 2 ml/h) and lipid (LIH; 10% Intralipid + 20 U/ml heparin; 2 ml/h) infusions to rats. Within 2 days of beginning the infusion of either lipid or glucose, plasma glucose profiles were normalized (relative to saline-infused control rats; SAL; 0.45% 2 ml/h). During glucose infusion, plasma glucose was maintained in the normal range by an approximately twofold increase in plasma insulin and an approximately 80% increase in beta-cell mass. During LIH infusion, glucose profiles were also maintained in the normal range. Plasma insulin responses during feeding were doubled, and beta-cell mass increased 54%. For both groups, the increase in beta-cell mass was associated with increased beta-cell proliferation (98% increase during GLC and 125% increase during LIH). At the end of the 4-day infusions, no significant changes were observed in islet-specific gene transcription (i.e., the expression of islet hormone genes, glucose metabolism genes, and insulin transcription factors were unaffected). Two days after termination of the infusions, the glucose-stimulated plasma insulin response was increased approximately 67% in glucose-infused animals. No sustained effect on insulin secretory capacity was observed in the LIH animals. The increase in plasma insulin response after glucose infusion was achieved in the absence of any change in insulin clearance. We conclude that, in rats, an increase in insulin demand after an increase in glucose appearance or free fatty acid leads to an increase in beta-cell mass, mediated in part by an increase in beta-cell proliferation, and that these compensatory changes lead to increased insulin secretion, normal plasma glucose levels, and the maintenance of normal islet gene expression.
<title>Recognition and quantitation of closely related chlorinated organic vapors with acoustic-wave chemical sensor arrays</title> (1999)

An array of four acoustic wave chemical sensors has been developed and tested for recognition and quantitation of six closely related chlorinated organic vapors at low part-per- million concentrations. These vapors include PCE, TCE, VC, and DCE, cis-1,2-DCE, trans-1,2-DCE, and 1,1-DCE. The developed sensor array can detect as little as 0.2 ppm of PCE, 0.8 ppm of TCE, 1.4 ppm of cis-1,2-DCE, 1.4 ppm of trans-1,2-DCE, 3 ppm of 1,1-DCE, and 3.5 ppm of VC in air. Quantitation of TCE and cis-1,2-DCE vapor mixtures was achieved using multivariate calibration techniques. The locally weighted regression analysis provides more accurate results over the partial least squares regression.
Switching properties of SrBi2Ta2O9 thin films produced by metalorganic decomposition (2000)

The process of polarization reversal in a SrBi2Ta2O9 (SBT) thin film capacitor produced by a metalorganic decomposition method was investigated. The switching time (100–600 ns) and the reversible polarization have been measured at different voltages in the range of 0–5 V. It was found that by annealing the SBT sample in AR atmosphere at 400 °C, the switching times were significantly reduced. This indicates that oxygen vacancies in the film speed up nucleation and growth of new domains.
Probing the Role of H-Ras Lipidation for Signaling Functions in Xenopus laevis Oocytes (2003)

The small guanosine nucleotide binding proteins of the ras- gene family act as molecular switches in the transduction of many extracellular signals from cell-surface receptors to the nucleus, and are involved in a variety of cellular processes from mitosis and differentiation to apoptosis (,). A hallmark of Ras activation is the conversion of inactive (GDP-bound) Ras to the active GTP-bound form, which then can selectively activate downstream signal transduction pathways. Ras has also been implicated in the pathogenesis of cancers, since malignant transformation in mammals is often associated with mutations in ras genes, which favor the GTP-bound, active form of Ras ().
Structural and Data Science-Driven Analysis to Assess Substrate Specificity of Diketopiperazine Reverse Prenyltransferase NotF: Cascade Biocatalytic Synthesis of (–)-Eurotiumin A (2021)

Prenyltransfer is an early-stage carbon–hydrogen bond (C–H) functionalization prevalent in the biosynthesis of a diverse array of biologically active bacterial, fungal, plant, and metazoan diketopiperazine (DKP) alkaloids. Towards the development of a unified strategy for biocatalytic construction of prenylated DKP indole alkaloids, we sought to identify and characterize a substrate-permissive C2 reverse prenyltransferase (PT). In the biosynthesis of cytotoxic notoamide metabolites, PT NotF is responsible for catalyzing the first tailoring event of C2 reverse prenyltransfer of brevianamide F (cyclo(L-Trp-L-Pro)). Obtaining a high-resolution crystal structure of NotF (in complex with native substrate and prenyl donor mimic dimethylallyl S-thiolodiphosphate (DMSPP)) revealed a large, solvent exposed substrate binding site, intimating NotF may possess significant substrate promiscuity. To assess the full potential of NotF’s broad substrate selectivity, we synthesized a panel of 30 tryptophanyl DKPs with a suite of sterically and electronically differentiated amino acids, which were selectively prenylated by NotF in often synthetically useful conversions (2 to >99%). Quantitative representation of this substrate library enabled the development of a descriptive statistical model that provided insight into the origins of NotF’s substrate promiscuity. Through this unique approach for understanding enzyme scope, we identified key substrate descriptors such as electrophilicity, size, and flexibility, that govern enzymatic turnover by NotF. Additionally, we demonstrated the ability to couple NotF-catalyzed prenyltransfer with oxidative cyclization using recently characterized flavin monooxygenase, BvnB, from the brevianamide biosynthetic pathway. This one-pot, in vitro biocatalytic cascade proceeds with exceptional substrate recognition, and enabled the first chemoenzymatic synthesis of the marine fungal natural product, (–)-eurotiumin A, in three steps and 60% overall yield.
Assessment of Digital PCR as a Primary Reference Measurement Procedure to Support Advances in Precision Medicine (2018)

This work validates dPCR as an SI-traceable reference measurement procedure based on enumeration and demonstrates how it can be applied for assignment of copy number concentration and fractional abundance values to DNA reference materials in an aqueous solution. High-accuracy measurements using dPCR will support the implementation and traceable standardization of molecular diagnostic procedures needed for advancements in precision medicine.
Silicon Schottky Diode Power Converters Beyond 100 GHz (2007)

This paper presents circuits based on Schottky barrier diodes (SBDs) in IBM's 0.13-μm SiGe BiCMOS process. Circuits such as sub-harmonic up-conversion mixers and frequency doublers are demonstrated at frequencies beyond 100 GHz on silicon. These circuits enable power generation at millimeter wave frequencies on silicon. The frequency doublers can deliver >0 dBm output power at 110 GHz and the 2X sub-harmonic up converters exhibit peak conversion loss of <3dB up to 120 GHz.
Evaluation of IR techniques for detection of wall thinning in service water piping (1996)

Service water piping systems at electric power plants provide cooling for a variety of safety and non-safety related components and systems. Assessing integrity of the service water piping system includes detection and analysis of pipe wall thinning. Conventional inspection techniques usually involve the time-intensive process of ultrasonic thickness measurements, based on a grid system, of the entire pipe length. An alternative to this process may lie in the use of active infrared thermography techniques for detection of thin wall areas in the pipe. The EPRI NDE Center participated in a preliminary evaluation of this technology at Vermont Yankee Nuclear Power Plant. Based on the promising results of the Vermont Yankee activity, the Center worked with Thermal Wave Imaging, Inc. (TWI) in an effort to optimize the IR thermal injection technique for service water piping applications. The primary goals of this effort were to determine the practical depth resolution capabilities of the thermal injection method in carbon steel, and also to minimize the effects of pipe curvature on detection capabilities. Both of these efforts were subject to the constraint that the system be sufficiently portable for use in an electrical power plant, where space and access to the pipe surface ismore » often limited.« less
On the Applicability of the Thermal Dose Cumulative Equivalent Minutes Metric to the Denaturation of Bovine Serum Albumin in a Polyacrylamide Tissue Phantom (2009)

Thermal dose has been proposed for various hyperthermic cancer treatment modalities as a measure of heat‐induced tissue damage. However, the applicability of current thermal dose metrics to tissue is not well understood, particularly at the temperatures and rates of heating relevant to ablative cancer therapy using High‐Intensity Focussed Ultrasound (HIFU). In this work, we assess whether the most widely employed thermal dose metric, Cumulative Equivalent Minutes (CEM), can adequately quantify heat‐induced denaturation in a tissue‐mimicking material (phantom) consisting of Bovine Serum Albumin (BSA) proteins embedded in a polyacrylamide matrix. The phantom is exposed to various temperature profiles and imaged under controlled lighting conditions against a black background as it denatures and becomes progressively more opaque. Under the assumption that the mean backscattered luminous intensity provides a good measure of the extent of BSA denaturation, we establish a relationship between the amount of thermal damage caused to the phantom, exposure time, and temperature. We demonstrate that, for monotonically increasing and bounded temperature profiles, the maximal degree to which the phantom can denature is dependent on the peak temperature it reaches, irrespective of exposure duration. We also show that when the CEM is computed using the commonly employed piecewise‐constant approximation of the parameter R, the CEM values corresponding to the same degree of damage delivered using different temperature profiles do not agree well with each other in general.
Clinical Implications of Mucinous Nonneoplastic Cysts of the Pancreas (2011)

This underappreciated entity belongs to the family of mucinous pancreatic cysts. However, unifying clinical characteristics that would prevent unnecessary resections in patients harboring these seemingly benign lesions are currently lacking.
Adoptive Immunotherapy with Autologous CD25-Depleted and CD3/CD28-Costimulated T-Cells (ACTC) Enhances Numeric and Functional Lymphocyte Recovery after Cyclophosphamide - Fludarabine Chemotherapy in Patients with Low-Grade Follicular Lymphoma. (2005)

Abstract Fludarabine-based chemotherapy combinations are highly effective in patients (pts) with low-grade follicular lymphoma (FL), but cause severe and long-lasting immunosuppression due to depletion of normal CD4 T-cells. Aside from increasing the risk of serious infections, this toxicity may limit the ability of the immune system to eliminate minimal residual disease. Adoptive immunotherapy using autologous CD25-depleted, CD3/CD28-costimulated T-cells expanded ex vivo (ACTC) may enhance immune reconstitution and improve disease control. We initiated a phase I study in pts with purine analog-naive relapsed/refractory FL (grades 1 and 2). After leukapheresis, pts receive 4 cycles of fludarabine (25 mg/m2) days 1–3 and cyclophosphamide (250 mg/m2) days 1–3. Four weeks after last chemotherapy, responding patients (CR, CRu, PR) receive escalating doses of ACTC prepared ex vivo from autologous T-cells collected prior to chemotherapy and depleted of regulatory CD4+/CD25+ cells, then expanded and activated using anti-CD3 and anti-CD28. Eight pts have been enrolled to date. Median age is 40.5 y (range: 32–64). Median number of prior therapies is 2 (range: 1–3). Two pts were withdrawn from the study due to hematologic toxicity related to the chemotherapy; one patient has not completed chemotherapy. Of the 5 pts completing chemotherapy, 3 pts achieved a CR and 2 pts achieved a PR; 4 pts received 5 x 109 and 1 patient received 1 x 1010 CD3+ ACTC. There have been no adverse events related to T-cell infusions. Median follow-up after ACTC infusion is 9 months (range: 2–15 months). Median time to CD4 count &amp;gt;200 /uL was 29 days following T-cell infusion (range 28–127 days). CD4 counts increased in all patients by 1 month after T-cell infusion, with a median increase of 126% from baseline (range 50 to 484%). CD8 counts also increased, with a median increase of 82% (range −4 to 976%). All 5 pts receiving ACTC were anergic to candida antigen by Delayed Type Hypersensitivity (DTH) skin testing before chemotherapy. Three pts developed a positive DTH response to candida antigen 60 days after ACTC infusion. From the start of therapy for patients receiving T-cells, median follow-up is 14 months (range 7–20 months) with median progression-free survival not reached; 4 pts remain in remission and 1 patient had progression of disease. ACTC results in significant CD4+ lymphocyte recovery in previously treated pts receiving cyclophosphamide-fludarabine chemotherapy and compares very favorably with historical controls. T-cell dose escalation is ongoing.
Design Strategy for Scale-Up of Physical Vapor Deposition of Cu(InGa) Se2 on Flexible Substrates (2006)

It has been observed that scale-up of the Cu(InGa)Se <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> physical vapor deposition (PVD) onto flexible substrates to wide webs and long runtimes will lead to unacceptable film qualities due to issues associated with the thermal characteristics of the source-boats and the effect of melt level reduction with time. These issues are the subject of the present paper. The difficulties encountered with the design of the sources presently in operation are addressed, and new designs are proposed that resolve the problem of thickness and composition uniformity over wider substrates (~12 inches). Simulation results are presented comparing the old source design with the proposed new one for a 12-inch wide substrate. It is shown that improved film thickness uniformity and hence composition uniformity is achieved with the proposed designs, and material utilization can be improved by an appropriate choice of system design parameters such as nozzle-to-substrate distance
Esthetic Evaluation of Implants Placed after Orthodontic Treatment in Patients with Congenitally Missing Lateral Incisors (2013)

This paper evaluates the esthetic outcome of Morse taper connection implants placed to restore congenitally missing lateral incisors after orthodontic treatment.
Expression and localization of vascular endothelial growth factor receptors in human hepatocellular carcinoma and non-HCC tissues. (2000)

Flt-1 (VEGF receptor-1) and KDR/Flk-1 (VEGF receptor-2) are the high-affinity receptors for the angiogenesis factor, vascular endothelial growth factor (VEGF). VEGF expression has been confirmed in human hepatocellular carcinoma (HCC), and VEGF is thought to be involved in the angiogenesis within HCC tissues. However, expressions of VEGF receptors in HCC have not been reported. We immunohistochemically examined expressions and localizations of Flt-1 and KDR in 28 surgically resected HCC tissues. In non-cancerous area, Flt-1 and KDR were mainly found in macrophages including Kupffer cells; both receptors were found in vascular endothelial cells in the portal veins and arteries within portal tracts; and KDR was also found in some sinusoidal endothelial cells. In cancerous area, Flt-1 and KDR were found in some macrophages, and also in the endothelial cells of intratumoral blood vessels. In 25 moderately and/or poorly differentiated HCCs, KDR expression in the blood space endothelial cells was clear and continuous in 20 cases, and focal in 5 cases. These results suggest that there would be an angiogenesis mechanism via VEGF/Flt-1 or VEGF/KDR in HCC, and the VEGF/KDR system would take a more important role.
Spectroscopic probes for hydrogen bonding, extraction impregnation and reaction in supercritical fluids (1993)

Spectroscopy is used for monitoring a number of processes relevant to solution, extraction and impregnation in supercritical CO2(scCO2). Examples include: a combined infrared (IR) and ultraviolet study of the interaction between para-hydroquinone (HQ) and tributyl phosphate in scCO2, which reveals hydrogen bonding, detected by the characteristic v(O–H) IR bands; IR measurement of the solubility of CpMn(CO)3(Cp =η5–C5H5) in scCO2 as a function of temperature and pressure; an investigation of the uniformity of supercritical impregnation of CpMn(CO)3 into 4 mm diameter pellets of polyethylene (PE) using Fourier-transform infrared (FTIR) microscopy and FTIR depth profiling by photoacoustic detection; and an IR study of the photochemical reaction of CpMn(CO)3 with N2 with PE film.