gebhart/patrepeval huggingface dataset:
Video 2 - ATMi increases the rate of mitotic catastrophe in glioma cells when p53 is knocked down. from Orally Bioavailable and Blood–Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice (2023)

&lt;p&gt;U87/Centrin2-EGFP/H2B-mCherry/puro cells were seeded on dishes with cover slip bottoms, treated with AZ32 (3 uM), and irradiated (5 Gy). Time-lapse videos were recorded intermittently (every 7 min) over 16 hrs. Treatment results in 11% aberrant mitoses (see Fig. 3F).&lt;/p&gt;
Predicting Earth magnetic anomalies from measured EMAG2 data (2016)

Magnetic anomaly maps are important for scientific and practical applications; such as they provide insight into the subsurface structure and composition of the Earth's terrestrial and oceanic crusts. These maps are widely applicable for geological exploration and detection of man-made subsurface anomalies. There is available high-resolution 2 arc-minute global Earth Magnetic Anomaly Grid data (EMAG2) at 4 km above the geoid [1], which has been created using various satellite, ship, and airborne magnetic measurements. However, many. if not all. practical applications require EMAG data at different elevations and different resolutions. To achieve this demand here EMAG2 data at 4 km elevation is remapped at different elevations and resolutions using the method of auxiliary sources. Comparisons between predicted and measured data are demonstrated.
Translocation in Bacillus subtilis: characterization of elongation factor G by peptidyl-[3H]puromycin synthesis (1976)

This communication describes the characterization of elongation factor G from Bacillus subtilis by the translocation of "native" peptide donors. Translocation was followed by elongation factor G-dependent increase in the synthesis of peptidyl-[3H]puromycin using "washed" ribosomes carrying in vivo-bound peptidyl-transfer ribonucleic acid ("native" peptidyl-transfer ribonucleic acid) molecules as peptide donors. Such ribosomes were obtained from cell extracts by washing at a high salt concentration. The use of "native" peptide donors facilitated the study of translocation under conditions that are closer to the in vivo state than those in the methods previously employed.
On the Potentials of Traffic Steering Techniques between HSDPA and LTE (2011)

In this paper traffic steering between a High-Speed Downlink Packet Access (HSDPA) network and a 3GPP Long Term Evolution (LTE) network with different carrier frequencies is investigated. First, two traffic steering algorithms, relying on static network information, are assessed from a traffic theoretical point of view and numerically. Furthermore, numerical analysis of two traffic steering algorithms, relying on dynamic information such as user SINR and cell load, is also performed. It is shown that the dynamic traffic steering algorithms outperform the static methods in terms of end user performance. Finally, it is investigated how the LTE terminal penetration affects the performance of the proposed traffic steering algorithms. For low LTE terminal penetration all LTE capable terminals should be pushed to the LTE network, and for high LTE terminal penetration a more dynamic traffic steering scheme should be used.
Methods for Improving Escalators (2008)

This paper presents several methods to search for improvements in escalator design. Escalators were invented more than a century ago. During this time several features have been developed although most of them have not show nany clear advantage over the conventional device. This mechanism is becoming a commodity product.C1TEF is using tools to simulate and to analyze the static, kinematic and dynamic behavior of this multibody system. We have used MATLAB, CATIA and SIMPACK software. In addition, a life prediction model based on dynamic results has been developed.
Méthodes de mesure de la surface équivalente radar d’antennes en bande millimétrique pour la caractérisation de transpondeurs MMID (2015)

National audience
Online Application Guidance for Heterogeneous Memory Systems (2022)

As scaling of conventional memory devices has stalled, many high-end computing systems have begun to incorporate alternative memory technologies to meet performance goals. Since these technologies present distinct advantages and tradeoffs compared to conventional DDR* SDRAM, such as higher bandwidth with lower capacity or vice versa, they are typically packaged alongside conventional SDRAM in a heterogeneous memory architecture. To utilize the different types of memory efficiently, new data management strategies are needed to match application usage to the best available memory technology. However, current proposals for managing heterogeneous memories are limited, because they either (1) do not consider high-level application behavior when assigning data to different types of memory or (2) require separate program execution (with a representative input) to collect information about how the application uses memory resources. This work presents a new data management toolset to address the limitations of existing approaches for managing complex memories. It extends the application runtime layer with automated monitoring and management routines that assign application data to the best tier of memory based on previous usage, without any need for source code modification or a separate profiling run. It evaluates this approach on a state-of-the-art server platform with both conventional DDR4 SDRAM and non-volatile Intel Optane DC memory, using both memory-intensive high-performance computing (HPC) applications as well as standard benchmarks. Overall, the results show that this approach improves program performance significantly compared to a standard unguided approach across a variety of workloads and system configurations. The HPC applications exhibit the largest benefits, with speedups ranging from 1.4× to 7× in the best cases. Additionally, we show that this approach achieves similar performance as a comparable offline profiling-based approach after a short startup period, without requiring separate program execution or offline analysis steps.
The deubiquitylase USP9X controls ribosomal stalling (2020)

When a ribosome stalls during translation, it runs the risk of collision with a trailing ribosome. Such an encounter leads to the formation of a stable di-ribosome complex, which needs to be resolved by a dedicated machinery. The initial stalling and the subsequent resolution of di-ribosomal complexes requires activity of Makorin and ZNF598 ubiquitin E3 ligases, respectively, through ubiquitylation of the eS10 and uS10 subunits of the ribosome. We have developed a specific small-molecule inhibitor of the deubiquitylase USP9X. Proteomics analysis, following inhibitor treatment of HCT116 cells, confirms previous reports linking USP9X with centrosome-associated protein stability but also reveals a loss of Makorin 2 and ZNF598. We show that USP9X interacts with both these ubiquitin E3 ligases, regulating their abundance through the control of protein stability. In the absence of USP9X or following chemical inhibition of its catalytic activity, levels of Makorins and ZNF598 are diminished, and the ribosomal quality control pathway is impaired.
Quantitative stress mapping in alumina composites by optical fluorescence imaging (1996)

Internal residual stresses exist in almost all polycrystalline materials and in many cases exert a profound influence on mechanical and physical behavior. In inherently brittle ceramics and ceramic composites, toughening mechanisms often depend sensitively on localized residual stresses. However, despite their prominence few studies are available which provide a detailed characterization of the local spatial variation of residual stress fields in ceramics and their composites. In this study, we report on the spatially resolved mapping of local residual and applied stresses in polycrystalline alumina and a variety of Al2O3SiCw composites. Stress mapping is based on the well established method of measuring shifts in the characteristic optical fluorescence lines produced by Cr3+ impurities in the alumina matrix. Novel illumination and imaging optics are used to collect up to 15,000 stress measurements from an area approx. 1 mm2. Detailed stress maps are generated which produce a vivid and quantitative indication of the complex residual stress fields present in these materials. The additional effect of a non-uniform applied stress field ahead of a blunt notch is also measured. Results are discussed in the context of thermal expansion anisotropy within the alumina phase, thermal expansion differences between the SiC-reinforcement and Al2O3 matrix, and the non-uniform distribution of whiskers. The mean value and fluctuation of the resultant residual stress fields are estimated by extension of recent stochastic mechanics models and compared to measured values.
Full Characterization of the Mechanical Properties of 11–50 nm Ultrathin Films: Influence of Network Connectivity on the Poisson’s Ratio (2017)

Precise characterization of the mechanical properties of ultrathin films is of paramount importance for both a fundamental understanding of nanoscale materials and for continued scaling and improvement of nanotechnology. In this work, we use coherent extreme ultraviolet beams to characterize the full elastic tensor of isotropic ultrathin films down to 11 nm in thickness. We simultaneously extract the Young's modulus and Poisson's ratio of low-k a-SiC:H films with varying degrees of hardness and average network connectivity in a single measurement. Contrary to past assumptions, we find that the Poisson's ratio of such films is not constant but rather can significantly increase from 0.25 to >0.4 for a network connectivity below a critical value of ∼2.5. Physically, the strong hydrogenation required to decrease the dielectric constant k results in bond breaking, lowering the network connectivity, and Young's modulus of the material but also decreases the compressibility of the film. This new understanding of ultrathin films demonstrates that coherent EUV beams present a new nanometrology capability that can probe a wide range of novel complex materials not accessible using traditional approaches.
Study of the optimum writing field at finite temperatures. (2000)

The optimum writing field at finite temperatures was simulated by using the Langevin equation, in the conditions where the recording density was constant (= 200 kfci) and the velocity was varied from 5 m/s to 100 m/s. In the higher-frequency range over 350 MHz, the optimum writing field does not depend on the thermal effect, but is determined by the magnetic anisotropy field Hk. We also studied the dependence of the optimum writing field on the distribution of the anisotropy field (Hk) and the easy axis orientation. The optimum writing field increases with increasing variance of Hk, but does not depend on the distribution of the anisotropy axis orientation.
Local inhibition of IL-4 and IL-13 protects lung function in OVA mouse model (2011)

DARPinsTM (Designed Ankyrin Repeat Proteins) are a novel class of proteins that combine the affinity and specificity properties of antibodies with the solubility and tissue penetration properties of small molecules. The excellent biophysical properties of DARPin domains allows for simple engineering of multispecificity by linking domains that target different ligands. DARPin134 is a bispecific DARPin that inhibits binding of murine IL-13 and IL-4 to their receptors. The bispecific molecule (DARPin134) or either of the mono-specific molecules was delivered to the lungs of mice via intra-tracheal instillation during an acute ovalbumin sensitization and challenge model. Free IL-4 and IL-13 levels were reduced in the BAL following treatment with DARPin134. While the anti-IL-4 and anti-IL-13 DARPins each showed a trend towards reducing eosinophils in the lungs of mice, the bi-specific DARPin significantly reduced eosinophil infiltration. In addition, an improvement airway hyper-responsiveness in mice treated with DARPin134 was observed. A variety of studies have confirmed the unique and overlapping roles for IL-13 and IL-4 in the pathology of asthma. Molecules inhibiting IL-4 alone have failed in clinical trials of asthma and a variety of clinical studies with molecules targeting IL-13 are ongoing. In contrast, DARPin134 targets both IL-4 and IL-13 and in vitro data demonstrate the bispecific DARPin has high potency, affinity and excellent biophysical properties. Blockade of both IL-4 and IL-13 in the pulmonary compartment could provide a therapeutic option in pulmonary diseases without disruption of either cytokine systemically.
Optimal proximity correction: application for flash memory design (1998)

Proximity Correction is the technology for which the most of IC manufacturers are committed already. The final intended result of correction is affected by many factors other than the optical characteristics of the mask-stepper system, such as photoresist exposure, post-exposure bake and development parameters, etch selectivity and anisotropy, and underlying topography. The most advanced industry and research groups already reported immediate need to consider wafer topography as one of the major components during a Proximity Correction procedure. In the present work we are discussing the corners rounding effect (which eventually cause electrical leakage) observed for the elements of Poly2 layer for a Flash Memory Design. It was found that the rounding originated by three- dimensional effects due to variation of photoresist thickness resulting from the non-planar substrate. Our major goal was to understand the reasons and correct corner rounding. As a result of this work highly effective layout correction methodology was demonstrated and manufacturable Depth Of Focus was achieved. Another purpose of the work was to demonstrate complete integration flow for a Flash Memory Design based on photolithography; deposition/etch; ion implantation/oxidation/diffusion; and device simulators.
Neoantigen cancer vaccine augments anti-CTLA-4 efficacy (2022)

Immune checkpoint inhibitors (ICI) based on anti-CTLA-4 (αCTLA-4) and anti-PD1 (αPD1) are being tested in combination with different therapeutic approaches including other immunotherapies such as neoantigen cancer vaccines (NCV). Here we explored, in two cancer murine models, different therapeutic combinations of ICI with personalized DNA vaccines expressing neoantigens and delivered by electroporation (EP). Anti-cancer efficacy was evaluated using vaccines with or without CD4 epitopes. Therapeutic DNA vaccines showed synergistic effects in different therapeutic protocols including established large tumors. Flow cytometry (FC) was utilized to measure CD8, CD4, Treg, and switched B cells as well as neoantigen-specific immune responses, which were also measured by IFN-γ ELIspot. Immune responses were augmented in combination with αCTLA4 but not with αPD1 in the MC38 tumor-bearing mice, significantly impacting tumor growth. Similarly, neoantigen-specific T cell immune responses were enhanced in combined treatment with αCTLA-4 in the CT26 tumor model where large tumors regressed in all mice, while monotherapy with αCTLA-4 was less efficacious. In line with previous evidence, we observed an increased switched B cells in the spleen of mice treated with αCTLA-4 alone or in combination with NCV. These results support the use of NCV delivered by DNA-EP with αCTLA-4 and suggest a new combined therapy for clinical testing.
Modal axial group velocity in ducted swirling flows and its application to the detection of broadband acoustic modes (2022)

This paper considers the modal axial group velocity and its application to broadband (BB) acoustic mode detection in ducted swirling flows, typical of the aeroengine interstage. The normalised modal axial group velocity (ϑ_mn, normalised by the sound speed c) has so far been an analytical construct in duct acoustics and not much use has been made of it to study the modal propagation. In this paper, we begin by developing the physical interpretation of
Multicenter Clinical Trial of Bortezomib in Relapsed/Refractory Waldenstrom's Macroglobulinemia: Results of WMCTG Trial 03-248 (2007)

The results of these studies show that bortezomib is an active agent in relapsed and refractory WM.
Regularised Model Identification Improves Accuracy of Multisensor Systems for Noninvasive Continuous Glucose Monitoring in Diabetes Management (2013)

Continuous glucose monitoring (CGM) by suitable portable sensors plays a central role in the treatment of diabetes, a disease currently affecting more than 350 million people worldwide. Noninvasive CGM (NI-CGM), in particular, is appealing for reasons related to patient comfort (no needles are used) but challenging. NI-CGM prototypes exploiting multisensor approaches have been recently proposed to deal with physiological and environmental disturbances. In these prototypes, signals measured noninvasively (e.g., skin impedance, temperature, optical skin properties, etc.) are combined through a static multivariate linear model for estimating glucose levels. In this work, by exploiting a dataset of 45 experimental sessions acquired in diabetic subjects, we show that regularisation-based techniques for the identification of the model, such as the least absolute shrinkage and selection operator (better known as LASSO), Ridge regression, and Elastic-Net regression, improve the accuracy of glucose estimates with respect to techniques, such as partial least squares regression, previously used in the literature. More specifically, the Elastic-Net model (i.e., the model identified using a combination of <svg style="vertical-align:-3.276pt;width:11.0375px;" id="M1" height="16.3125" version="1.1" viewBox="0 0 11.0375 16.3125" width="11.0375" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(.017,-0,0,-.017,.062,12.162)"><path id="x1D459" d="M238 681l-124 -585q-7 -31 4 -31q10 0 37.5 18.5t49.5 41.5l16 -22q-40 -48 -89.5 -81.5t-76.5 -33.5q-42 0 -16 122l105 488q7 32 0 41t-39 9h-35l5 26q35 3 71 13t58 17.5t26 7.5q14 0 8 -31z" /></g> <g transform="matrix(.012,-0,0,-.012,4.637,16.25)"><path id="x31" d="M384 0h-275v27q67 5 81.5 18.5t14.5 68.5v385q0 38 -7.5 47.5t-40.5 10.5l-48 2v24q85 15 178 52v-521q0 -55 14.5 -68.5t82.5 -18.5v-27z" /></g> </svg> and <svg style="vertical-align:-3.276pt;width:11.0375px;" id="M2" height="16.3125" version="1.1" viewBox="0 0 11.0375 16.3125" width="11.0375" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(.017,-0,0,-.017,.062,12.162)"><use xlink:href="#x1D459"/></g> <g transform="matrix(.012,-0,0,-.012,4.637,16.25)"><path id="x32" d="M412 140l28 -9q0 -2 -35 -131h-373v23q112 112 161 170q59 70 92 127t33 115q0 63 -31 98t-86 35q-75 0 -137 -93l-22 20l57 81q55 59 135 59q69 0 118.5 -46.5t49.5 -122.5q0 -62 -29.5 -114t-102.5 -130l-141 -149h186q42 0 58.5 10.5t38.5 56.5z" /></g> </svg> norms) has the best results, according to the metrics widely accepted in the diabetes community. This model represents an important incremental step toward the development of NI-CGM devices effectively usable by patients.
Millimeter-Wave and Power Characterization for Integrated Circuits (2009)

International audience
Reactions of Acetylide Clusters Cp*WRe2(CO)9(CCR) [R = Ph, C(Me):CH2, and Cyclohexenyl] with Thiophenol. Formation of WRe2 Thiolate Alkyne and Vinylalkylidyne Derivatives (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of Acetylide Clusters Cp*WRe2(CO)9(CCR) [R = Ph, C(Me):CH2, and Cyclohexenyl] with Thiophenol. Formation of WRe2 Thiolate Alkyne and Vinylalkylidyne DerivativesJiunn-Jang Peng, Shie-Ming Peng, Gene-Hsiang Lee, and Yun ChiCite this: Organometallics 1995, 14, 2, 626–633Publication Date (Print):February 1, 1995Publication History Published online1 May 2002Published inissue 1 February 1995https://pubs.acs.org/doi/10.1021/om00002a009https://doi.org/10.1021/om00002a009research-articleACS PublicationsRequest reuse permissionsArticle Views45Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Silicon Photomultipliers Coupled to Scintillators With the Emission Maximum at 550 nm (2022)

A majority of the silicon photomultipliers (SiPMs) are sensitive to blue and near-ultraviolet (NUV) photons that are not optimized for scintillators with the emission maximum at wavelengths longer than 500 nm. The red–green–blue (RGB) SiPM is developed for the maximum photon detection efficiency (PDE) at 550 nm, which is a good match for some high-light-yield scintillators, such as CsI:Tl (CsI) and Gd <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1.5</sub> Y <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1.5</sub> Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</sub> :Ce (GYGAG). Comparisons are made for the performance of these scintillators coupled to the RGB SiPM and a blue-sensitive SiPM. Because it takes tens of nanoseconds for the microcells to recharge after registering a photon hit, the linearity of these scintillation detectors was studied for high-energy gammas where numerous scintillation photons are generated. In addition, the energy resolution of the 662-keV gamma emitted by <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">137</sup> Cs was measured for temperatures between −20 °C and 50 °C. The nonlinearity was observed above 1 MeV for all measurements, and however, it can be corrected by energy calibration using a third-degree polynomial. For CsI, the energy resolution is better with the blue-sensitive SiPM because of the lower dark count rate (DCR). In contrast, GYGAG coupled to the RGB SiPM has a better energy resolution for temperatures below 30 °C because of the well-matched emission spectrum and PDE distribution. Nevertheless, the advantage disappears for temperatures above 30 °C due to the higher DCR. It would be useful to further develop the RGB SiPM with a lower DCR and higher operating temperatures.