gebhart/patrepeval huggingface dataset:
Platelet Factor 4 (PF4) Antigenic Complexes on the Macrophage Surface: Implications for the Pathogenesis of Heparin Induced Thrombocytopenia (HIT). (2006)

Abstract HIT is the most frequent antibody-mediated drug-induced thrombocytopenia and is unique in the associated prevalence of thrombosis. HIT is caused by antibodies to a normal host protein, PF4, complexed to heparin or cellular glycosaminoglycans (GAGs). We have shown that binding of HIT antibodies and a monoclonal HIT-like antibody KKO to platelet surface chondroitin sulfate (CS) follows a bell-shaped curve with respect to PF4 concentration. At external PF4 concentrations below the peak value of &amp;lt;50 μg/mL, heparin dissociates PF4 and thereby decreases surface antigenicity, whereas at PF4 concentrations &amp;gt;50 μg/mL, heparin initially increases antigenicity. Surface GAGs on macrophages differ from those on platelets in several ways, including having a higher affinity for PF4. In addition, the binding of HIT-IgG elicits the elaboration of tissue factor. Therefore, we characterized the binding of HIT IgG antibody to macrophages exposed to different concentrations of PF4. Binding of PF4 to the surface of human/murine macrophages also followed a bell-shaped curve with peak antigenicity at the same PF4 concentration as seen on platelets. However, HIT antigenticity persisted at lower PF4 concentrations. For example at a PF4 concentration of 6 μg/mL, six times as much KKO bound to macrophages as to platelets. PF4-coated monocytes were also more resistant to the abrogation of KKO binding by heparin. At therapeutic concentrations of heparin, HIT antigenicity actually increased on macrophages exposed to optimal concentrations of PF4, while platelet surface antigenicity was nearly eliminated. Enzymatic removal of surface GAGs showed that unlike platelet surfaces, where CS is the major GAG involved in HIT antigenicity, a more complex pattern was seen on macrophages that included heparan sulfates, CS and likely dermatan sulfates. Thus, these studies show that expression of surface HIT antigenic complexes on macrophages develop at much lower concentrations of PF4 than platelets and that these complexes are more resistant to removal by heparin. The enhanced avidity of macrophages for PF4/GAG complexes may also contribute to the persistent risk of thrombosis for at least several days after heparin exposure has been stopped. Whether measurement of antigenic complexes on macrophages would identity patients at higher risk of thrombosis and whether reduction in the risk of thrombosis requires measures directed at the integrity of these complexes in addition to use of direct thrombin inhibitors are under investigation.
Iron‐Catalyzed Cross‐Coupling Reactions: Efficient Synthesis of 2,3‐Allenol Derivatives. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Off-set filtering for enhanced transmission in RSOA based WDM-PON (2013)

We present an experimental analysis on externally seeded colourless transmitters for WDM PON. We take advantage of direct modulation of a high performance MQW RSOA. Chirp is analysed as main limiting factor to SSMF propagation at 10 Gb/s. We demonstrate that off-set filtering performed by the OLT demultiplexer allows to cope with chromatic dispersion impairments and to bridge 24-km SSMF at 10 Gb/s with modest penalties with respect to back to back.
New Tetraazacrown Ethers Containing Two Pyridine, Quinoline, 8-Hydroxyquinoline, or 8-Aminoquinoline Sidearms (1999)

A series of macrocyclic tetraazacrown ethers containing two pyridine, quinoline, 8-hydroxyquinoline, or 8-aminoquinoline sidearms has been prepared. Crab-like cyclization of bis(alpha-chloroacetamide)s and diamines followed by reduction of the cyclic diamides was used to synthesize the selected crown ethers containing two unsubstituted macroring nitrogen atoms. The preparation of the macrocycles with sidearms was accomplished by reductive amination of the proper aldehydes with the crown ethers using sodium triacetoxyborohydride (NaBH(OAc)(3)) as the reducing agent. The 8-hydroxyquinoline- and 8-aminoquinoline-containing macrocycles were synthesized by reductive amination of 8-acetoxyquinoline-2-carboxaldehyde or 8-nitroquinoline-2-carboxaldehyde followed by removing the acetate groups or reducing the nitro groups to amino groups, respectively. Complexation of ligand 22 with Cu(2+), Co(2+), Ni(2+), Zn(2+), Cd(2+), and Pb(2+) was evaluated potentiometrically in aqueous solution (0.10 M Me(4)NCl) at 25 degrees C. Ligand 22 formed very stable complexes with these metal ions. The UV-vis spectra of 22 and its complexes were examined in an aqueous acetic acid buffer solution (pH 5). The 22-Cu(2+) complex provided a new absorption band at 258 nm.
HotGPT: How to Make Software Documentation More Useful with a Large Language Model? (2023)

It is well known that valuable information is contained in the natural language components of software systems, like comments and manual, and such information can be used to improve system performance and reliability. Past research has attempted to extract such information through task-specific machine learning models and tool chains. Here, we investigate a general, one-model-fit-all solution through a state-of-the-art large language model (e.g., the GPT series). Our investigation covers three representative tasks: extracting locking rules from comments, synthesizing exception predicates from comments, and identifying performance-related configurations; it reveals challenges and opportunities in applying large language models to system maintenance tasks.
Met144Ala mutation of the copper‐containing nitrite reductase from Alcaligenes xylosoxidans reverses the intramolecular electron transfer (2004)

Pulse radiolysis has been employed to investigate the intramolecular electron transfer (ET) between the type 1 (T1) and type 2 (T2) copper sites in the Met144Ala Alcaligenes xylosoxidans nitrite reductase (AxCuNiR) mutant. This mutation increases the reduction potential of the T1 copper center. Kinetic results suggest that the change in driving force has a dramatic influence on the reactivity: The T2Cu(II) is initially reduced followed by ET to T1Cu(II). The activation parameters have been determined and are compared with those of the wild-type (WT) AxCuNiR. The reorganization energy of the T2 site in the latter enzyme was calculated to be 1.6+/-0.2 eV which is two-fold larger than that of the T1 copper center in the WT protein.
The Chemistry and Physical Properties of Structural Adhesives (2012)

No AccessAdhesion and Adhesives TechnologyJun 2012The Chemistry and Physical Properties of Structural AdhesivesAlphonsus V. PociusAlphonsus V. Pociushttps://doi.org/10.3139/9783446431775.008SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetailsCited byDurability of Structural Adhesive BondsAlphonsus V. Pocius24 June 2012 2012Pages: 219-258Print ISBN: 978-3-446-42748-8eISBN: 978-3-446-43177-5 Copyright & Permissions© 2012 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Tuning the Light Emission from GaAs Nanowires over 290 meV with Uniaxial Strain (2012)

Strain engineering has been used to increase the charge carrier mobility of complementary metal-oxide-semiconductor transistors as well as to boost and tune the performance of optoelectronic devices, enabling wavelength tuning, polarization selectivity and suppression of temperature drifts. Semiconducting nanowires benefit from enhanced mechanical properties, such as increased yield strength, that turn out to be beneficial to amplify strain effects. Here we use photoluminescence (PL) to study the effect of uniaxial stress on the electronic properties of GaAs/Al0.3Ga0.7As/GaAs core/shell nanowires. Both compressive and tensile mechanical stress were applied continuously and reversibly to the nanowire, resulting in a remarkable decrease of the bandgap of up to 296 meV at 3.5% of strain. Raman spectra were measured and analyzed to determine the axial strain in the nanowire and the Poisson ratio in the <111> direction. In both PL and Raman spectra, we observe fingerprints of symmetry breaking due to anisotropic deformation of the nanowire. The shifts observed in the PL and Raman spectra are well described by bulk deformation potentials for band structure and phonon energies. The fact that exceptionally high elastic strain can be applied to semiconducting nanowires makes them ideally suited for novel device applications that require a tuning of the band structure over a broad range.
Mitral Isthmus Block in a Case of Persistent Left Superior Vena Cava (2010)

Persistent left superior vena cava (LSVC), an uncommon venous anomaly, could be an arrhythmogenic source of atrial fibrillation. Multiple electrical connections were reported between the LSVC and the left atrium, which may negatively impact the achievement of conduction block during linear ablation of left mitral isthmus. We describe a case with perimitral atrial flutter (AFL) in a patient with isolated LSVC. AFL was successfully treated and complete perimitral conduction block was achieved following a lengthy epicardial radiofrequency application.
Oracle SecureFiles System (2008)

Over the last decade, the nature of content stored on computer storage systems has evolved from being relational to being semi-structured, i.e., unstructured data accompanied by relational metadata. Average data volumes have increased from a few hundred megabytes to hundreds of terabytes. Simultaneously, data feed rates have also increased with increase in processor, storage and network bandwidths. Data growth trends seem to be following Moore's law and thereby imply an exponential explosion in content volumes and rates in the years to come. The near future poses requirements for data management systems to provide solutions that provide unlimited scalability in execution, availability, recoverability and storage usage of semi-structured content. Traditionally, filesystems have been preferred over database management systems for providing storage solutions for unstructured data, while databases have been the preferred choice to manage relational data. Lack of consolidated semi-structured content management architecture compromises security, availability, recoverability, and manageability among other features. We introduce a system without compromises, the Oracle SecureFiles System, designed to provide highly scalable storage and access execution of unstructured and structured content as first-class objects within the Oracle relational database management system. Oracle SecureFiles breaks the performance barrier that has kept such content out of databases. The architecture provides capability to maximize utilization of storage usage through compression and de-duplication and achieves robustness by preserving transactional atomicity, durability, availability, read-consistent query-ability and security of the database management system.
ICONE19-43273 INVESTIGATION OF CRITICAL HEAT FLUX IN THE ROD BUNDLE USING MECHANISTIC APPROACH IN CONJUNCTION WITH THE SUBCHANNEL CODE (2011)

Critical Heat Flux (CHF) is one of the important parameters for the thermal design of a rod bundle. Subchannel analysis is recommended in the absence of experimental data to determine the thermal margin of a new fuel design using empirical correlations. However, there are a large number of empirical CHF correlations available even for a simple geometry which indicates that a generic correlation with wide range of validity is not available in the literature and hence mechanistic approach could be more appropriate. A mechanistic model based on the Liquid Film Dryout approach with the constitutive models suitable for the BWR conditions have been employed in conjunction with the subchannel code COBRA-IIIC. This paper deals with the film dryout analysis of a typical BWR fuel bundle considering a simplified mechanistic approach in conjunction with the subchannel code.
Task-space/joint-space damping transformations for passive redundant manipulators (2002)

Passive mechanical wrists, capable of imparting a desired damping matrix to a grasped workpiece are discussed. The passive mechanical wrist is to be programmable-it can adopt a wide range of damping matrices-by virtue of a number of tunable dampers which interconnect the joints. The range of damping matrices that such a wrist can adopt is studied, purely by tuning its dampers. It is found that a redundant wrist has a broader range of realizable damping matrices than a non-redundant wrist. A kinematic Jacobian relates the task-space damping matrix to a similar matrix in the hydraulic space of the tunable dampers (joint-space). For redundant wrists, the transformation of damping matrices between task-space and joint-space is not straightforward. The causal directions along which the transformations are linear are identified. It is shown that the joint-space matrices which are obtained as linear transformations of desired task-space matrices are all singular. Many realizable joint-space matrices (corresponding to a desired task-space damping matrix) are shown to exist which are discovered by linear transformations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Reducing Peripheral Inflammation with Infliximab Reduces Neuroinflammation and Improves Cognition in Rats with Hepatic Encephalopathy (2016)

Inflammation contributes to cognitive impairment in patients with hepatic encephalopathy (HE). However, the process by which peripheral inflammation results in cognitive impairment remains unclear. In animal models, neuroinflammation and altered neurotransmission mediate cognitive impairment. Taking into account these data, we hypothesized that in rats with HE: (1) peripheral inflammation is a main contributor to neuroinflammation; (2) neuroinflammation in hippocampus impairs spatial learning by altering AMPA and/or NMDA receptors membrane expression; (3) reducing peripheral inflammation with infliximab (anti-TNF-a) would improve spatial learning; (4) this would be associated with reduced neuroinflammation and normalization of the membrane expression of glutamate receptors. The aims of this work were to assess these hypotheses. We analyzed in rats with portacaval shunt (PCS) and control rats, treated or not with infliximab: (a) peripheral inflammation by measuring prostaglandin E2, IL10, IL-17, and IL-6; (b) neuroinflammation in hippocampus by analyzing microglial activation and the content of TNF-a and IL-1b; (c) AMPA and NMDA receptors membrane expression in hippocampus; and (d) spatial learning in the Radial and Morris water mazes. We assessed the effects of treatment with infliximab on peripheral inflammation, on neuroinflammation and AMPA and NMDA receptors membrane expression in hippocampus and on spatial learning and memory. PCS rats show increased serum prostaglandin E2, IL-17, and IL-6 and reduced IL-10 levels, indicating increased peripheral inflammation. PCS rats also show microglial activation and increased nuclear NF-kB and expression of TNF-a and IL-1b in hippocampus. This was associated with altered AMPA and NMDA receptors membrane expression in hippocampus and impaired spatial learning and memory in the radial and Morris water maze. Treatment with infliximab reduces peripheral inflammation in PCS rats, normalizing prostaglandin E2, IL-17, IL-6, and IL-10 levels in serum. Infliximab also prevents neuroinflammation, reduces microglial activation, translocates NF-kB into nucleoli and normalizes TNF-a and IL-1b content in hippocampus. This was associated with normalization of AMPA receptors membrane expression in hippocampus and of spatial learning and memory. The results suggest that peripheral inflammation contributes to spatial learning impairment in PCS rats. Treatment with anti-TNF-a could be a new therapeutic approach to improve cognitive function in patients with HE.
Figure S5 from Detection of Promoter DNA Methylation in Urine and Plasma Aids the Detection of Non–Small Cell Lung Cancer (2023)

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Lipid nanocarriers targeting breast cancers to delivery modulators of estrogens receptors (2011)

International audience
Estimating Total Lung Volume from Pixel-level Thickness Maps of Chest Radiographs Using Deep Learning (2021)

Purpose: To estimate the total lung volume (TLV) from real and synthetic frontal chest radiographs (CXR) on a pixel level using lung thickness maps generated by a U-Net deep learning model. Methods: This retrospective study included 5,959 chest CT scans from two public datasets: the lung nodule analysis 2016 (n=656) and the Radiological Society of North America (RSNA) pulmonary embolism detection challenge 2020 (n=5,303). Additionally, 72 participants were selected from the Klinikum Rechts der Isar dataset (October 2018 to December 2019), each with a corresponding chest radiograph taken within seven days. Synthetic radiographs and lung thickness maps were generated using forward projection of CT scans and their lung segmentations. A U-Net model was trained on synthetic radiographs to predict lung thickness maps and estimate TLV. Model performance was assessed using mean squared error (MSE), Pearson correlation coefficient (r), and two-sided Student's t-distribution. Results: The study included 72 participants (45 male, 27 female, 33 healthy: mean age 62 years [range 34-80]; 39 with chronic obstructive pulmonary disease: mean age 69 years [range 47-91]). TLV predictions showed low error rates ($MSE_{Public-Synthetic}$=0.16 $L^2$, $MSE_{KRI-Synthetic}$=0.20 $L^2$, $MSE_{KRI-Real}$=0.35 $L^2$) and strong correlations with CT-derived reference standard TLV ($n_{Public-Synthetic}$=1,191, r=0.99, P&lt;0.001; $n_{KRI-Synthetic}$=72, r=0.97, P&lt;0.001; $n_{KRI-Real}$=72, r=0.91, P&lt;0.001). The Luna16 test data demonstrated the highest performance, with the lowest mean squared error (MSE = 0.09 $L^2$) and strongest correlation (r = 0.99, P &lt;0.001) for TLV estimation. Conclusion: The U-Net-generated pixel-level lung thickness maps successfully estimated TLV for both synthetic and real radiographs.
Detection of encapsulation in Staphylococcus aureus by use of antiserum agar (1984)

We examined an antiserum agar method to study its reliability in screening Staphylococcus aureus strains for capsule production. The encapsulated S. aureus Smith diffuse strain was compared with its nonencapsulated variant, Smith compact, in CCY medium containing 0.5% NaCl and 5.0% Smith diffuse rabbit antiserum. A halo was visible surrounding colonies of the Smith diffuse strain but not the Smith compact strain. On this same medium, the protein A-producing Cowan I strain possessed a halo that was visible on photographs. Single high-salt medium is known to inhibit protein A production, halo formation by the strains was also compared in 7.5% NaCl medium. The halo surrounding the Cowan I strain was not present when the salt content of the medium was increased. In contrast, the halo surrounding the Smith diffuse strain persisted in the 7.5% NaCl medium. By use of this medium, the antiserum agar technique may be valuable for the identification of encapsulated staphylococci without appreciable interference from protein A.
Dynamic high contrast reflective coloration from responsive polymer/cholesteric liquid crystal architectures (2011)

We report on high reflectivity CLC structures (R > 50%) whose wavelength can be thermally tuned reversibly by a de-swelling/re-swelling transition unique to ordered solvent-gel systems. The system contains no chiral dopant and the coloration is completely induced by a responsive chiral structured gel. The de-swelling transition, leading to blue tuning, occurs at the nematic-isotropic transition of the liquid crystal, which is a result of a mismatch in the orientational energy of the isotropic liquid crystal and the anisotropic gel. The re-swelling transition subsequently occurs at the nematic-isotropic transition of gel, due to the miscibility of the isotropic liquid crystal and the isotropic gel, which induces a red-shift in the coloration. Examination of varying clearing point liquid crystal solvents, contact angle measurements, and white light optical profilometry localized thickness measurements shed light on this de-swelling/re-swelling transition. A dynamic, high reflectivity cell was demonstrated by combining both a left-handed chiral gel with a right handed chiral gel, both of whose initial periodicities were equal. Heating of this so-called hyper-reflective cell drove reversible and large scale wavelength changes (100's of nm) while maintaining large reflectivity (R ∼ 90%).
On sensor selection in linked information networks (2011)

Sensor networks are often redundant by design in order to achieve reliability in information processing. In many cases, the relationships between the different sensors are known a-priori, and can be represented as virtual linkages among the different sensors. These virtual linkages correspond to an information network of sensors, which provides useful external input to the problem of sensor selection. In this paper, we propose the unique approach of using external linkage information in order to improve the efficiency of very large scale sensor selection. We design efficient theoretical models, including a greedy approximation algorithm and an integer programming formulation for sensor selection. Our greedy selection algorithm provides an approximation bound of (e -1)/(2 · e -1), where e is the base of the natural logarithm. We show that our approach is much more effective than baseline sampling strategies. We present experimental results that illustrate the effectiveness and efficiency of our approach.
Actual States of Corrosion and Corrosion Control Methods of Steel Structures in Marine Environments (1989)

The actual states of corrosion of steel structures in marine environments based on field investigations are introduced. Especially the states of intensive corrosion under mean low water level and the conditions in which such corrosion has a tendency to occur are shown. And the design of corrosion control methods is reviewed.
A highly selective electron affinity facilitated H2S sensor: the marriage of tris(keto-hydrazone) and an organic field-effect transistor (2020)

Conjugated polymers (CPs) are emerging as part of a promising future for gas-sensing applications. However, some of their limitations, such as poor specificity, humidity sensitivity and poor ambient stability, remain persistent. Herein, a novel combination of a polymer-monomer heterostructure, derived from a CP (PDVT-10) and a newly reported monomer [tris(keto-hydrazone)] has been integrated in an organic field-effect transistor (OFET) platform to sense H<sub>2</sub>S selectively. The hybrid heterostructure shows an unprecedented sensitivity (525% ppm<sup>-1</sup>) and high selectivity toward H<sub>2</sub>S gas. In addition, we demonstrated that the PDVT-10/tris(keto-hydrazone) OFET sensor has the lowest limit of detection (1 ppb), excellent ambient stability (∼5% current degradation after 150 days), good response-recovery behavior, and exceptional electrical behavior and gas response reproducibility. This work can help pave the way to incorporate futuristic gas sensors in a multitude of applications.
Association of epicardial fat with cardiac structure and function and cardiovascular outcomes: A protocol for systematic review and meta-analysis (2023)

INPLASY 202280109.
A 2‐DAY MLR PROCEDURE FOR MARROW DONOR SELECTION FOR ALLOGENEIC BONE MARROW TRANSPLANTATION (1993)

In this report we demonstrate the clinical application of a two‐day mixed leukocyte reaction (MLR) test for bone marrow (BM) donor selection in three patients of aplastic anaemia who needed an urgent bone marrow transplantation (BMT).