gebhart/patrepeval huggingface dataset:
Combined Treatment with Short Synthetic Anti-Lymphoma Peptide and CpG ODN; A Therapeutic Vaccine Which cures the A20 Lymphoma in Balb/C Mice. (2008)

Abstract Background. The short synthetic peptide 302 has been shown to induce rapid membrane disruption of lymphoma cells in vitro and necrosis of local tumors in the A20 lymphoma model in Balb/c mice. In order to stimulate the immune system to generate an anti-tumor response we designed a model where intra-tumor injections of peptide 302 was combined with sc injections of the Toll-like receptor 9 binding synthetic oligonucleotide CpG 1826. Methods. Balb/c mice were inoculated with A20 lymphoma cells sub-cutaneously (s.c.) on the abdomen. When the tumors reached a size of 5–7 mm, 302 peptide was administered directly into the tumors on days 1 and 6. CpG 1826 was injected s.c. on days 1–4 and 6–8. Tumor growth was measured repeatedly during follow-up. A20-specific T-cell responses were detected by culturing peripheral blood lymphocytes from treated animals for 24 hours with A20 lymphoma cells and analyzing for intracellular IFN-γ production by flow cytometry. To dissect the role of T-cell subtypes, the treatment was performed in animals depleted for CD4 or CD8 positive T-cells. In order to show A20 specific immunological memory, cured animals were re-challenged with the A20 lymphoma or the carcinoma cell line CT26. Results. Combined treatment with peptide 302 and CpG 1826 cured 8 out of 10 mice, compared to only 2 out of 10 mice who received peptide 302 alone or CpG 1826 alone. Cured mice were followed for 9 weeks without relapsing. Similar results with the combination of peptide 302 and CpG were observed in a separate experiment. The highest cure rate was achieved when injecting CpG 1826 s.c. in the tumors draining lymph node area as compared to administration of CPG 1826 in a non-draining lymph node region or intra-peritoneal. Animals treated with peptide 302 + CpG 1826 or CpG 1826 alone developed CD8-specific IFN-γ responses against A20 cells. In one separate experiment CD8 knock-out mice did not respond to the treatment, unlike animals depleted for CD4+ cells and normal mice. Only 1 out of 10 cured animals re-challenged with the A20 lymphoma developed a new tumor, a result that was reproduced in a second experiment. Conclusion: Treatment with intra-tumor injections of the anti-lymphoma peptide 302 in combination with CpG 1826 s.c. in the draining lymph node region cured established A20 tumors, induced tumor-specific CD8 positive tumor-reactive T-cells, and induced specific immunological memory. This principle represents a novel therapeutic vaccine approach.
Model predictive control of industrial loads and energy storage for demand response (2016)

With the potential to enhance the power system's operational flexibility in a cost-effective way, demand response is gaining increased attention worldwide. Industrial loads such as cement crushing plants consume large amounts of electric energy and therefore are prime candidates for the provision of significant amounts of demand response. They have the capability to turn on/off an arbitrary number of their crushers thereby adjusting their electric power consumption. However, the change in power consumption by cement crushing plants and also other industrial loads are often not granular enough to provide valuable ancillary services such as regulation and load following. In this paper, we propose a coordination method based on model predictive control to overcome the granularity restriction with the help of an energy storage.
Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design (2023)

Inhibition of NF-κB inducing kinase (NIK) has been pursued as a promising therapeutic target for autoimmune disorders due to its highly regulated role in key steps of the NF-κB signaling pathway. Previously reported NIK inhibitors from our group were shown to be potent, selective, and efficacious, but had higher human dose projections than desirable for immunology indications. Herein we report the clearance-driven optimization of a NIK inhibitor guided by metabolite identification studies and structure-based drug design. This led to the identification of an azabicyclo[3.1.0]hexanone motif that attenuated in vitro and in vivo clearance while maintaining NIK potency and increasing selectivity over other kinases, resulting in a greater than ten-fold reduction in predicted human dose.
SWOG S0919: A phase II study of idarubicin and cytarabine in combination with pravastatin for relapsed acute myeloid leukemia (AML). (2013)

7028 Background: Inhibition of cholesterol synthesis and uptake sensitizes AML blasts to chemotherapy (Blood 104: 1816, 2004). A prior Phase 1 study demonstrated the safety of high dose pravastatin given with idarubicin and cytarabine in patients with AML and also reported an encouraging response rate (Blood 109: 2999, 2007). SWOG S0919 therefore evaluated the complete remission (CR) rate in a larger number of pts with relapsed AML treated with the pravastatin dose arrived at in the Phase 1 trial. Methods: Pts were treated at SWOG institutions from Aug 2009 through Nov 2012. Pravastatin was supplied by Bristol-Meyers Squibb. The protocol was approved by each institution’s review board. Eligibility: age ≥ 18 yrs, relapsed AML, cardiac ejection fraction ≥ 45%, CR/ CR with incomplete count recovery (CRi) following most recent chemotherapy lasting ≥ 3 months, no prior hematopoietic cell transplant. Treatment: oral pravastatin 1280 mg Days 1-8, idarubicin 12 mg/m 2 /d IV Days 4-6, and cytarabine 1.5 g/m 2 /d continuous IV infusion Days 4-7. Pts achieving a CR could receive 2 cycles of consolidation. CR and CRi were defined by IWG criteria. Fifty eligible pts were to be accrued. If ≥ 21 pts achieved CR or CRi, the regimen would be considered sufficiently effective (critical level = 4.8% if true CR rate = 30% and power of 90% if true CR rate = 50%). Results: The study closed to accrual on Nov 1, 2012 after meeting the defined criterion for a positive study. Thirty-six pts with a median age of 59 yr (range 23-78) were enrolled. Seventeen pts (47%) were male and the median WBC was 2800/ uL (range 700-110,600). The median time from initial dx to registration was 18 mo (range 5-136). Relapse status: 1 st : 17 pts (47%), 2 nd : 15 (42%), 3 rd : 2 (5.5%), and 4 th : 2 (5.5%). Eighteen pts have died, 3 during treatment. The response rate was 75% (95% CI 58-88%; 20 CR, 7 CRi); and the median overall survival was 10 mo. The p-value comparing 75% to 30% (null response rate) is 3.356 x 10 -8 . Duration of last CR (≤ 6 months) and prior high dose cytarabine exposure did not affect response to protocol treatment. Conclusions: The CR/ CRi in this relapsed population is encouraging. We plan to evaluate the efficacy of this regimen in higher-risk patients. Clinical trial information: NCT00840177.
Pickering-type stabilized nanoparticles by heterophase polymerization (2013)

The preparation of nanoparticles in a soap-free system is highly attractive, as surfactants may influence and deteriorate subsequent applications. Thereby, the assembly of solid particles on droplets/particles is well known as Pickering-type stabilization. The resulting hybrid nanocomposites offer in general a rough surface and are highly intriguing for potential drug delivery systems, coating applications, and so forth. This review highlights developments in production and application of Pickering-type nanoparticles synthesized via heterophase polymerization techniques in emulsion, miniemulsion, dispersion, and suspension. We will focus our discussion on systems, wherein stabilization of the final nanometer-sized hybrids is exclusively accomplished via particle stabilizers. In case surfactants are used during preparation, they only serve as pre-treating agents to modify the surface properties of the particle stabilizer, and not being employed for the purpose of droplet/particle stabilization.
A Wide Input Range Isolated Stacked Resonant Switched-Capacitor dc-dc Converter for High Conversion Ratios (2018)

This paper presents an isolated dc-dc converter architecture for high conversion ratios using the stacked resonant switched-capacitor topology. Capacitive isolation is adopted in place of transformer isolation for saving cost and platform size. With phase shift operation, the topology can support a wide input range with a simple regulation scheme while enabling zero-voltage switching. The topology can be adapted to high conversion ratios via addition of stacking levels while keeping the same magnetics. The experimental results demonstrate a 2-Stack example achieving a peak efficiency of 92.8% and a peak power density of 283 W/inch <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> with 92% efficiency. The converter can also maintain within 3% efficiency drop over 25%-100% load range, and 50%-100% input range.
Catastrophic-optical-damage-free InGaN laser diodes with epitaxially-formed window structure (2010)

High power over 2W free from catastrophic-optical-damage is achieved in InGaN-based lasers with epitaxially-formed window structure. Epitaxial growth over a recess reduces the In composition which eliminates the undesired optical absorption only at the facet.
Synthesis of copolyamides based on PA 66 bearing lithium sulfonate groups and having unique thermal properties (2011)

International audience
Selective Hydrodeoxygenation of Glycerol to 1,2-Propanediol with the Pt/CeO2–ZrO2 Catalyst (2022)

An active and selective catalyst 1%Pt/CeO2–ZrO2 for glycerol hydrodeoxygenation to 1,2-propanediol was synthesized. The reaction was carried out in water under relatively mild conditions: a temperature of 170°C and a hydrogen pressure of 10 atm for 6 h. The glycerol conversion reached 82% with a 74% selectivity to 1,2-propanediol. The high activity and selectivity of the catalyst are due to the high degree of dispersion of supported platinum nanoparticles with a size of less than 2 nm, the optimal Ce : Zr ratio in a mixed oxide support, high specific surface area, and the presence of weak Brønsted acid sites. The presence of zirconium in the mixed oxide support not only gives rise to additional defects in the cerium oxide structure, but also stabilizes the deposited platinum nanoparticles.
Serializability Improves Parallel Execution of Production System (1995)

This paper presents a new production system architecture that uses serializability as a correctness criterion to select a set of productions to be executed in parallel. The use of serializability eliminales global synchronization. This architecture takes advantage of modern associative memory devices to allow parallel production firing, concurrent matching, and overlap among matching, selection, and firing of productions. A comprehensive event driven simulator is used to evaluate the scaling properties of the new architecture and to compare it with a parallel architecture using global synchronization before every production firing. Our results indicate that the combination of serializability and associative memories can achieve substantial improvements in speed with a very modest increase in hardware cost.
Transport studies of insulin across rat jejunum in the presence of chicken and duck ovomucoids (2001)

Our aim was to evaluate the transport of insulin across rat jejunum in the presence of ovomucoids and to assess the effect of ovomucoids on intestinal tissue by studying the permeation of a lipophilic and a hydrophilic marker. Rat jejunal segments were mounted in a side-by-side diffusion chamber filled with Krebs bicarbonate buffer, bubbled with 95% O2/5% CO2 at a fixed flow rate and maintained at 37 degrees C. The permeation of insulin, a lipophilic marker ([7- 3H] testosterone) and a hydrophilic marker (D-[1- 14C] mannitol) was evaluated in the presence of 0.5-1.5 microM duck ovomucoid (DkOVM) or chicken ovomucoid (CkOVM). For stability and permeation of insulin in the presence of alpha-chymotrypsin, an enzyme-to-inhibitor ratio of 1:1 and 1:2 was used. In the absence of alpha-chymotrypsin, the permeability coefficient (Papp) of insulin at pH 7.4 was 0.922+/- 0.168 x 10(-7) cm s(-1), which decreased with increasing concentrations of DkOVM or CkOVM. Conversely, the permeation of the hydrophilic and lipophilic marker increased with increasing concentrations of CkOVM and DkOVM. In stability studies, the percentage of drug remaining was found to be 2-fold higher at the 1:2 ratio than with the 1:1 ratio of enzyme to inhibitor. This was in agreement with the 2-fold increase in flux values of insulin in the presence of alpha-chymotrypsin and DkOVM at the 1:2 ratio of enzyme to inhibitor. The decrease in permeation of insulin in ovomucoids was unexpected. Marker transport studies indicated that ovomucoids have the potential to modulate transcellular and paracellular permeability. The flux enhancement of insulin in the presence of alpha-chymotrypsin and DkOVM is encouraging. The use of ovomucoids offers potential to enhance oral delivery of insulin and warrants further investigation.
Mechanisms of Unphosphorylated STAT3 Transcription Factor Binding to DNA (2012)

Phosphorylation of signal transducer and activator of transcription 3 (STAT3) on a single tyrosine residue in response to growth factors, cytokines, interferons, and oncogenes activates its dimerization, translocation to the nucleus, binding to the interferon γ (gamma)-activated sequence (GAS) DNA-binding site and activation of transcription of target genes. STAT3 is constitutively phosphorylated in various cancers and drives gene expression from GAS-containing promoters to promote tumorigenesis. Recently, roles for unphosphorylated STAT3 (U-STAT3) have been described in response to cytokine stimulation, in cancers, and in maintenance of heterochromatin stability. However, the mechanisms underlying U-STAT3 binding to DNA has not been fully investigated. Here, we explore STAT3-DNA interactions by atomic force microscopy (AFM) imaging. We observed that U-STAT3 molecules bind to the GAS DNA-binding site as dimers and monomers. In addition, we observed that U-STAT3 binds to AT-rich DNA sequence sites and recognizes specific DNA structures, such as 4-way junctions and DNA nodes, within negatively supercoiled plasmid DNA. These structures are important for chromatin organization and our data suggest a role for U-STAT3 as a chromatin/genome organizer. Unexpectedly, we found that a C-terminal truncated 67.5-kDa STAT3 isoform recognizes single-stranded spacers within cruciform structures that also have a role in chromatin organization and gene expression. This isoform appears to be abundant in the nuclei of cancer cells and, therefore, may have a role in regulation of gene expression. Taken together, our data highlight novel mechanisms by which U-STAT3 binds to DNA and supports U-STAT3 function as a transcriptional activator and a chromatin/genomic organizer.
Sterile Field Contamination by Elastomeric Respirators Versus Surgical Masks and N95s (2020)

Abstract Background: Elastomeric respirators are reusable and reliable protection from infectious aerosol particles such as SARS-CoV-2. There is a lack of safety data for use in sterile fields limiting application to operating room settings where high-risk aerosol generating procedures are performed. We hypothesized an equivalent reduction in sterile field contamination would be achieved using an elastomeric respirator covered by a surgical mask as compared to a standard surgical mask or N95. Methods: Randomized controlled crossover experiment with repeat measurement comparing microbial and aerosol contamination of operating room surfaces for elastomeric respirators, elastomeric respirators covered by a surgical mask, N95, surgical mask, and no mask. 80 experiments were performed by participants with randomized order and balanced crossover to all masking groups (n=16 per masking group). Participants executed droplet and aerosol generating procedures while wearing: (Group 1) elastomeric respirator with mask, (Group 2) elastomeric respirator only, (Group 3) N95, and (Group 4) surgical mask. Positive control was established with the participant unmasked (Group 5). Contamination was measured by microbial growth on settling plates and optical particle counters (0.2+ and 2 um+ particles). Results: There was a reduction in microbial contamination at the sterile field (p&lt;0.001) for all masks (Groups 1-4) compared to unmasked (Group 5). The mean colony forming units (CFU) at the sterile field was 0 CFUs for elastomeric respirator (+/- mask), N95, and surgical mask versus unmasked growing 1.875 CFUs. Compared to the unmasked control, the elastomeric respirator (+/- mask), N95, and surgical masks all resulted in a -0.75 difference in contamination (95% CI -0.91 to -0.48, p &lt; 0.001). No significant difference in contamination between the elastomeric respirator (+/- mask) and a surgical mask was detected. No significant difference in particle counts (0.2 µm+ and 2.0 µm+) between the elastomeric respirator (+/- mask) and a standard surgical mask. Conclusion and Relevance: Elastomeric respirators with or without mitigation are as effective as a surgical mask and N95 for reducing contamination at the sterile field in an operating room. Consideration should be given to expanding the use of elastomeric respirators to operating rooms during high-risk aerosol generating procedures.
Exploring the millimetre emission in nearby galaxies: Analysis of the edge-on galaxy NGC 891 (2022)

New observations of the edge-on galaxy NGC 891, at 1.15 and 2mm obtained with the IRAM 30-m telescope and the NIKA2 camera, within the framework of the IMEGIN (Interpreting the Millimetre Emission of Galaxies with IRAM and NIKA2) Large Program, are presented in this work. By using multiwavelength maps (from the mid-IR to the cm wavelengths) we perform SED fitting in order to extract the physical properties of the galaxy on both global and local (~kpc) scales. For the interpretation of the observations we make use of a state-of-the-art SED fitting code, HerBIE (HiERarchical Bayesian Inference for dust Emission). The observations indicate a galaxy morphology, at mm wavelengths, similar to that of the cold dust emission traced by submm observations and to that of the molecular gas. The contribution of the radio emission at the NIKA2 bands is very small (negligible at 1.15 mm and ~ 10% at 2 mm) while it dominates the total energy budget at longer wavelengths (beyond 5 mm). On local scales, the distribution of the free-free emission resembles that of the dust thermal emission while the distribution of the synchrotron emission shows a deficiency along the major axis of the disc of the galaxy.
XEL (1994)

Extended ephemeral logging (XEL) is a more general variation of the ephemeral logging (EL) technique for managing a log of database activity on disk; it does not require a timestamp to be maintained with each object in the database. XEL does not require periodic checkpoints and does not abort lengthy transactions as frequently as traditional firewall logging for the same amount of disk space. Therefore, it is well suited for concurrent databases and applications which have a wide distribution of transaction lifetimes.
RFID tags localization along an axis using a tunable near-field focused circular-phase array antenna (2011)

A novel concept for RFID tag localization using a tunable near-field focused circular-phase array antenna working at 5.8 GHz is presented. It serves as the reader antenna and focuses the power into a small region, in the tag vicinity. By scanning the focal spot along one axis and monitoring the differential scattered power by a tag, its position along the axis is easily computed with good accuracy. This simple localization scheme is well adapted for specific localization scheme, for example for objects placed over a conveyor belt.
Equivalent Elmore delay for RLC trees (2003)

Closed form solutions for the 50% delay, rise time, overshoots, and settling time of signals in an RLC tree are presented, These solutions have the same accuracy characteristics as the Elmore delay model for RC trees and preserves the simplicity and recursive characteristics of the Elmore delay. The solutions introduced here consider all damping conditions of an RLC circuit including the underdamped response, which is not considered by the classical Elmore delay model due to the non-monotone nature of the response. Also, the solutions have significantly improved accuracy as compared to the Elmore delay for an overdamped response. The solutions introduced here for RLC trees can be practically used for the same purposes that the Elmore delay is used for RC trees.
Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shortening (2012)

Telomere overhangs are essential for telomere end protection and telomerase extension, but how telomere overhangs are generated is unknown. Leading daughter strands synthesized by conventional semiconservation DNA replication are initially blunt, while lagging daughter strands are shorter by at least the size of the final RNA primer, which is thought to be located at extreme chromosome ends. We developed a variety of new approaches to define the steps in the processing of these overhangs. We show that the final lagging RNA primer is not terminal but is randomly positioned ~70-100 nucleotides from the ends and is not removed for more than an hour. This identifies an important intrinsic step in replicative aging. Telomeric termini are processed in two distinct phases. During the early phase, which occupies 1-2 h following replication of the duplex telomeric DNA, several steps occur on both leading and lagging daughters. Leading telomere processing remains incomplete until late S/G2, when the C-terminal nucleotide is specified-referred to as the late phase. These observations suggest the presence of previously unsuspected complexes and signaling events required for the replication of the ends of human chromosomes.
Light modulation performance control of the coating on the repaired damage sites in fused silica surface (2020)

The predecessor of China Optics was China Optics and Applied Optics Digest, which was founded in 1985. At that time, it was the only retrieval journal in the field of optics in China. At the end of 2008, China Optics and Applied Optics Digest was renamed
Capacity of Multiple One-Bit Transceivers in a Rayleigh Environment (2018)

We analyze the channel capacity of a system with a large number of one-bit transceivers in a classical Rayleigh environment with perfect channel information at the receiver. With $M$ transmitters and $N=αM$ receivers, we derive an expression of the capacity per transmitter $\mathcal{C}$, where $\mathcal{C}\leq\min(1,α)$, as a function of $α$ and signal-to-noise ratio (SNR) $ρ$, when $M\to\infty$. We show that our expression is a good approximation for small $M$, and provide simple approximations of $\mathcal{C}$ for various ranges of $α$ and SNR $ρ$. We conclude that at high SNR, $\mathcal{C}$ reaches its upper limit of one only if the ratio $α&gt;1.24$. Expressions for determining when $\mathcal{C}$ "saturates" as a function of $α$ and $ρ$ are given.
ChemInform Abstract: Efficient Syntheses of New Classes of Regiochemically Pure Benzoporphyrin Derivatives. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.