gebhart/patrepeval huggingface dataset:
Diabetic Kidney Disease: Act Now or Pay Later (2010)

Review Articles| February 22 2010 Diabetic Kidney Disease: Act Now or Pay Later Subject Area: Nephrology Robert C. Atkins; Robert C. Atkins School of Public Health and Preventive Medicine, Monash University, Melbourne, Vic., Australia Search for other works by this author on: This Site PubMed Google Scholar Paul Zimmet Paul Zimmet School of Public Health and Preventive Medicine, Monash University, Melbourne, Vic., Australia Search for other works by this author on: This Site PubMed Google Scholar Blood Purif (2010) 29 (3): 317–320. https://doi.org/10.1159/000285529 Article history Published Online: February 22 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Robert C. Atkins, Paul Zimmet; Diabetic Kidney Disease: Act Now or Pay Later. Blood Purif 1 March 2010; 29 (3): 317–320. https://doi.org/10.1159/000285529 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBlood Purification Search Advanced Search This content is only available via PDF. © 2008 S. Karger AG, Basel2010Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Abschreckung einst und heute (2018)

Kurzfassung: In einer Zeit, in der sich die internationalen Beziehungen in eine Richtung entwickeln, die stärker von strategischer Konfrontation gekennzeichnet ist, nimmt Abschreckung wieder einen zentralen Stellenwert ein. Der Artikel gibt einen Überblick über die Kernfragen westlicher Abschreckungspolitik während des Kalten Krieges und in der heutigen Zeit. Während sich die Umstände erheblich geändert haben, bleibt auch heute das zentrale Anliegen von Abschreckung dasselbe wie im Kalten Krieg: Wie hält man angesichts von Gegnern, die ihrerseits mit verheerenden Atomangriffen Vergeltungsschläge gegen die Vereinigten Staaten ausführen können, die Glaubwürdigkeit der US-amerikanischen Drohung aufrecht, auch zur Verteidigung von Alliierten Atomwaffen einzusetzen? Es besteht kaum ein Zweifel an der Glaubwürdigkeit der Drohung der Vereinigten Staaten oder anderer Atommächte, im Fall eines Atomangriffs auf ihre eigenen Staatsgebiete Vergeltung zu üben, sofern die Vergeltungskapazitäten den Erstangriff überstehen. Das Problem liegt in der Glaubwürdigkeit der erweiterten US-amerikanischen Abschreckung.
Analysis of pulsed laser plasmon-assisted photothermal heating and bubble generation at the nanoscale (2012)

A study is presented of photothermal effects associated with nanosecond-pulsed laser-illuminated subwavelength metallic nanoparticles in aqueous solutions. Computational electromagnetic and fluid analysis are used to model fundamental aspects of the photothermal process taking into account energy conversion within the nanoparticle at plasmon resonance, heat transfer to the fluid, homogeneous bubble nucleation, and the dynamic behaviour of the bubble and surrounding fluid. Various nanoparticle geometries are modelled including spheres, nanorods and tori. The analysis demonstrates that the laser intensity and pulse duration can be tuned to achieve controllable bubble generation without exceeding the melting temperature of the particle. The analysis also shows that the particle geometry can be tuned to optimize photothermal energy conversion for bubble generation at wavelengths that span the UV to NIR spectrum. Multiparticle systems are studied and a cooperative heating effect is demonstrated for particles that are within a few radii of each other. This provides more robust bubble generation using substantially reduced laser energy as compared to single-particle systems. The modelling approach is discussed in detail and should be of considerable use in the development of new photothermal applications.
Chemical and Biological Aspects of Nutritional Immunity - Perspectives for New Anti-infectives Targeting Iron Uptake Systems : Perspectives for New Anti-infectives Targeting Iron Uptake Systems (2017)

Upon bacterial infection, one of the defense mechanisms of the host is the withdrawal of essential metal ions, in particular iron, which leads to "nutritional immunity". However, bacteria have evolved strategies to overcome iron starvation, for example, by stealing iron from the host or other bacteria through specific iron chelators with high binding affinity. Fortunately, these complex interactions between the host and pathogen that lead to metal homeostasis provide several opportunities for interception and, thus, allow the development of novel antibacterial compounds. This Review focuses on iron, discusses recent highlights, and gives some future perspectives which are relevant in the fight against antibiotic resistance.
Modular multilevel converter as a low inductance machine drive (2012)

Many high performance machines are high speed, use permanent magnets, and have a low turns number in conjunction with minimal to no iron. Under these circumstances, the inductance of the machine is very low, i.e. the design of a voltage sourced power electronics drive is challenging from a current regulation/ripple perspective. Traditional approaches to correct this issue include external line reactors between the drive and machine or high switching frequencies. Implemented individually, these techniques are not optimal as external reactors may be bulky and high switching frequencies may cause additional losses in the drive and degrade the mechanical structure of the machine via parasitic coupling. This paper presents the use of a modular multilevel converter (MMC) to drive a low inductance machine. The MMC topology is unique via its ability to combine the operational characteristics of voltage and current source converter topologies to drive zero inductance loads while regulating current.
Distribution of GABA receptor ρ subunit transcripts in the rat brain (1998)

The gamma-aminobutyric acid (GABA) receptor rho subunits recently cloned from rat and human retina are thought to form GABA receptor channels belonging to a pharmacologically distinct receptor class, termed GABA(C). In this work we have examined the distribution of rho1, rho2 and rho3 subunits, and found expression of all three transcripts in several regions of the rat nervous system. In situ hybridization revealed expression of rho2 in the adult rat retina and some other parts of the visual pathways. A high local rho2 expression was seen in the superficial grey layer of the superior colliculus, and in the dorsal lateral geniculate nucleus. Expression was also detected in the 6th layer of visual cortex and in the CA1 pyramidal cell layer of hippocampus. With reverse transcriptase-polymerase chain reaction, expression of rho1 was mainly seen in the adult rat retina and dorsal root ganglia, as well as, at a significantly lower level, in the superior colliculus, hippocampus, brain stem, thalamus, postnatal day 8 (P8) superior colliculus and P8 hippocampus. Expression pattern of rho3 mRNA was clearly different from that of rho1 and rho2, being strongest in the hippocampus, and significantly lower in the retina, dorsal root ganglia and cortex. No rho3 expression was observed in adult or P8 superior colliculus or in P8 hippocampus. The present results clearly demonstrate that expression of GABA receptor rho subunits is not restricted to the retina, but significant expression can also be detected in many other brain regions, especially in those belonging to the visual pathways. The expression pattern of the rho subunits may be helpful in solving the functional significance of the receptors formed from these subunits.
Total ionizing dose effects in passivated and unpassivated AlGaN/GaN HEMTs (2016)

Significant shifts in threshold voltage have been observed during 10-keV X-ray irradiation of passivated and unpassivated AlGaN/GaN HEMTs. Oxygen and hydrogen impurities are found to contribute to differences in threshold voltage shifts and transconductance degradation for the passivated and unpassivated devices.
Dynamically pruning segformer for efficient semantic segmentation (2021)

As one of the successful Transformer-based models in computer vision tasks, SegFormer demonstrates superior performance in semantic segmentation. Nevertheless, the high computational cost greatly challenges the deployment of SegFormer on edge devices. In this paper, we seek to design a lightweight SegFormer for efficient semantic segmentation. Based on the observation that neurons in SegFormer layers exhibit large variances across different images, we propose a dynamic gated linear layer, which prunes the most uninformative set of neurons based on the input instance. To improve the dynamically pruned SegFormer, we also introduce two-stage knowledge distillation to transfer the knowledge within the original teacher to the pruned student network. Experimental results show that our method can significantly reduce the computation overhead of SegFormer without an apparent performance drop. For instance, we can achieve 36.9% mIoU with only 3.3G FLOPs on ADE20K, saving more than 60% computation with the drop of only 0.5% in mIoU
Future Directions and the Path Forward (2018)

<strong>20.1 Disappointment at Current Lack of Progress</strong> Despite the impressive accomplishments that have steadily accumulated since the 1960s that now consist of the publication of thousands of peer-reviewed papers [that can be retrieved by a PubMed search using the MeSH term “LLLT” and a new MeSH term “photobiomodulation therapy” (PBM)] and hundreds of clinical trials, many of which have been high-quality, randomized, and well-controlled, LLLT has still not reached the stage of acceptance by mainstream medicine. There remains considerable skepticism (and sometimes frank disbelief) amongst biomedical scientists, the medical profession, and the public at large. The reasons for this skepticism and disbelief are many and various, and they differ depending on the source. Biomedical scientists often refer to a lack of mechanism and the absence of agreement on dosimetry and parameters. Physicians often claim there is a lack of large clinical trials and not enough systematic reviews. Hospital and insurance administrators cannot agree on coverage and reimbursement. Finally (and regrettably), there has been marketing hype, over-promising, and frank misinformation from some of the companies that make devices (lasers, LED arrays, mixed clusters) that are used in the LLLT industry.
Stochastic Feedback Combustion Control at High Dilution Limit (2018)

Cycle-to-cycle variability in the combustion process of spark ignition engines imposes limits when operating at highly diluted conditions. When exhaust gas recirculation (EGR) is used to achieve higher fuel efficiency, the combustion variability (CV) increases due to the reduction in flame propagation speed. A tight control is required to operate close to such limit with minimum variability to maximize EGR benefits. A linear quadratic Gaussian (LQG) controller has been designed to drive the system towards a high efficiency condition with high EGR without deteriorating CV. The controller manipulates spark advance (SA) and EGR-valve opening to target a desired operating condition. The closed-loop system however does not need to be designed only for transient response but also for steady state operation. The directionality of the open-loop system at the target condition is shown to be problematic. Rejection of disturbances along the directions with low plant gain requires large control signals that could drive the system towards misfiring conditions. Moreover, such control commands could be perceived by the driver as torque fluctuations, jeop-ardizing drivability. This limitations at the high dilution limit are discussed and simulated results are provided.
Nanotechnology-Based Nucleic Acid Vaccines for Treatment of Ovarian Cancer (2022)

Anticancer vaccines represent a promising approach for effective treatment of cancer and along with recent advantages of nucleic acid-based vaccines for other diseases form a prospective and potentially efficacious direction of the research, development and clinical applications. Despite the ongoing several clinical trials of mRNA vaccines for the treatment of various types of cancer, to-date no cancer vaccines were approved by the US Food and Drug Administration. The present review analyzes and summarizes major approaches for treating of different forms of ovarian cancer including mRNA-based vaccines as well as nanotechnology-based approaches for their delivery.
Neurotrophic Factors in Parkinson’s Disease: Clinical Trials, Open Challenges and Nanoparticle-Mediated Delivery to the Brain (2021)

Neurotrophic factors (NTFs) are small secreted proteins that support the development, maturation and survival of neurons. NTFs injected into the brain rescue and regenerate certain neuronal populations lost in neurodegenerative diseases, demonstrating the potential of NTFs to cure the diseases rather than simply alleviating the symptoms. NTFs (as the vast majority of molecules) do not pass through the blood-brain barrier (BBB) and therefore, are delivered directly into the brain of patients using costly and risky intracranial surgery. The delivery efficacy and poor diffusion of some NTFs inside the brain are considered the major problems behind their modest effects in clinical trials. Thus, there is a great need for NTFs to be delivered systemically thereby avoiding intracranial surgery. Nanoparticles (NPs), particles with the size dimensions of 1-100 nm, can be used to stabilize NTFs and facilitate their transport through the BBB. Several studies have shown that NTFs can be loaded into or attached onto NPs, administered systemically and transported to the brain. To improve the NP-mediated NTF delivery through the BBB, the surface of NPs can be functionalized with specific ligands such as transferrin, insulin, lactoferrin, apolipoproteins, antibodies or short peptides that will be recognized and internalized by the respective receptors on brain endothelial cells. In this review, we elaborate on the most suitable NTF delivery methods and envision "ideal" NTF for Parkinson's disease (PD) and clinical trial thereof. We shortly summarize clinical trials of four NTFs, glial cell line-derived neurotrophic factor (GDNF), neurturin (NRTN), platelet-derived growth factor (PDGF-BB), and cerebral dopamine neurotrophic factor (CDNF), that were tested in PD patients, focusing mainly on GDNF and CDNF. We summarize current possibilities of NP-mediated delivery of NTFs to the brain and discuss whether NPs have impact in improving the properties of NTFs and delivery across the BBB. Emerging delivery approaches and future directions of NTF-based nanomedicine are also discussed.
A novel EER transmitter using two-point delta-sigma modulation scheme for WLAN and 3G applications (2003)

A novel transmitter architecture is proposed for wireless local area networks (WLAN) and 3/sup rd/ generation (3G) mobile applications. The transmitter is based on the envelope elimination and restoration (EER) architecture applied with two-point delta-sigma modulator (TPDSM). It can integrate digital modulators and power amplifiers without mixers effectively. In addition, the power amplifier can deal with non-constant envelope modulations like QPSK highly efficiently.
Novel rapid‐cure adhesives for low temperature using thiirane compound (2001)

We investigated improvement of workability (viscosity), storage stability, and curing ability of thiirane resin for adhesive applications. The viscosity of bisphenol-F thiirane resin was lower than that of bisphenol-A thiirane resin, especially at low temperatures, thus improving ease of handling. Addition of diphenyl decyl phosphite improved its storage stability to a level similar to that of bisphenol-A epoxy resin. The curing of bisphenol-F thiirane resin increased three times faster by adding 2,4,6-tris(dimethylaminomethyl)phenol (DMP-30) as a tertiary amine. In applications of this new thiirane resin as civil and architectural adhesives, a superior curing ability at low temperature was attained. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 82: 2953–2957, 2001
Forwarding and Control Element Separation (ForCES) MIB (2010)

This memo defines a Management Information Base (MIB) module for use with network management protocols in the Internet community.In particular, it defines managed objects for the Forwarding and Control Element Separation (ForCES) Network Element (NE).
Dendritic effect in polymer-supported catalysis of the intramolecular Pauson–Khand reaction (2002)

A remarkable increase in catalytic activity and selectivity in the intramolecular Pauson-Khand reaction is observed for Co complexes, immobilised on second- and third-generation dendron-functionalized polystyrene, as compared with their analogues on non-dendronized support.
Supplemental Figure 1 from CUE-101, a Novel E7-pHLA-IL2-Fc Fusion Protein, Enhances Tumor Antigen-Specific T-Cell Activation for the Treatment of HPV16-Driven Malignancies (2023)

&lt;p&gt;Supplementary Figure 1. Characterization of CUE-101 binding properties.&lt;/p&gt;
Requirements and Technologies Towards UAM: Communication, Navigation,\n and Surveillance (2020)

Urban air mobility (UAM) is a concept for creating an airborne transportation\nsystem that operates in urban settings with an on-board pilot and/or remote\npilot in command (RPIC), or with a fully autonomous architecture. Although the\npassenger traffic will be mostly in and near urban environments, UAM is also\nbeing considered for air cargo, perhaps between cities. Such capability is\npushing the current communication, navigation and surveillance (CNS) / air\ntraffic management (ATM) systems that were not designed to support these types\nof aviation scenarios. The UAM aircraft will be operating in a congested\nenvironment, where CNS and ATM systems need to provide integrity, robustness,\nsecurity, and very high availability for safety of UAM operations while\nevolving. As UAM is under research by academia and government agencies, the\nindustry is driving technology towards aircraft prototypes. Critical UAM\nrequirements are derived from command and control (C2) (particularly for RPIC\nscenario), data connectivity for passengers and flight systems, unmanned\naircraft systems (UAS) to UAS communication to avoid collision, and data\nexchange for positioning and surveillance. In this paper, we study connectivity\nchallenges and present requirements towards a robust UAM architecture through\nits concept of operations. In addition, we review the existing/potential CNS\ntechnologies towards UAM, i.e., 3rd generation partnership project (3GPP) fifth\ngeneration (5G) new radio (NR), navigation detect &amp; avoid (DAA), and satellite\nsystems and present conclusions on a future road-map for UAM CNS architecture.\n
Acute post-traumatic stress symptoms and age predict outcome in military blast concussion (2015)

High rates of adverse outcomes have been reported following blast-related concussive traumatic brain injury in US military personnel, but the extent to which such adverse outcomes can be predicted acutely after injury is unknown. We performed a prospective, observational study of US military personnel with blast-related concussive traumatic brain injury (n = 38) and controls (n = 34) enrolled between March and September 2012. Importantly all subjects returned to duty and did not require evacuation. Subjects were evaluated acutely 0-7 days after injury at two sites in Afghanistan and again 6-12 months later in the United States. Acute assessments revealed heightened post-concussive, post-traumatic stress, and depressive symptoms along with worse cognitive performance in subjects with traumatic brain injury. At 6-12 months follow-up, 63% of subjects with traumatic brain injury and 20% of controls had moderate overall disability. Subjects with traumatic brain injury showed more severe neurobehavioural, post-traumatic stress and depression symptoms along with more frequent cognitive performance deficits and more substantial headache impairment than control subjects. Logistic regression modelling using only acute measures identified that a diagnosis of traumatic brain injury, older age, and more severe post-traumatic stress symptoms provided a good prediction of later adverse global outcomes (area under the receiver-operating characteristic curve = 0.84). Thus, US military personnel with concussive blast-related traumatic brain injury in Afghanistan who returned to duty still fared quite poorly on many clinical outcome measures 6-12 months after injury. Poor global outcome seems to be largely driven by psychological health measures, age, and traumatic brain injury status. The effects of early interventions and longer term implications of these findings are unknown.