gebhart/patrepeval huggingface dataset:
Application of Rheological Analysis for Dispersion System of Fine Particles (2013)

The relationships between suspension rheology and its effect of UV-protection for various suspensions were analyzed, such as particle type, particle size, particle surface properties, and type of dispersants. The objective of this study is to achieve the effective UV-protective method by use of the accurate control of suspension rheology. The rheological properties are studied for suspension of ultra-fine TiO2 dispersed in silicone oil containing polyoxyethylene(POE) -modified silicones as dispersants. The effects of dispersion stability are evaluated through rheological methods and the flocculation mechanisms are discussed as a function of the molecular structures and HLB (Hydrophilic-lipophilic balance) of POE-modified silicones. The UV-protecting ability of suspensions of ultra-fine TiO2 particles is also discussed in relation to degree of flocculation. Furthermore, the study of rheological behavior is used complex suspensions of TiO2 and ZnO. The role of dispersants in heterogeneous flocculation behavior will be discussed in relation to their molecular structures to determine the optimum formulation of sunscreen cosmetics with high UV-protecting ability in both UVA and UVB regions. In the various cosmetics fields, the technology which formulates oil-in-water type emulsion containing fine particles in inner oil phase is the most general of them all. That can give the high UV-protection performance, smooth texture like non-powder, and natural color on the skin. The development and the application for this technology are additionally expected in cosmetic industries.
CIM-SECDED: A 40nm 64Kb Compute In-Memory RRAM Macro with ECC Enabling Reliable Operation (2021)

Resistive RAM (RRAM) is a promising candidate for compute in-memory (CIM) applications owing to its natural multiply-and-accumulate structure in a 1T-1R bitcell, high-bit density, non-volatility, and voltage and process compatibility. These properties seek to advance applications such as AI with higher throughput and bit-density. However, due to process, temperature, and write-to-write variations the resistive state of each RRAM undergoes both spatial and temporal variations. Significant effort has been made to reduce the impact of device variation using iterative write verify (IWV) or training-aware approaches [1]. Unfortunately, traditional ECC is not compatible with CIM when multiple cells are read simultaneously on the same bitline. To address this issue at the circuit level, this paper presents a 64Kb RRAM macro in 40nm CMOS supporting SECDED (single error correction, double error detection) scheme compatible with CIM for any number of parallel row accesses. Compared to prior work, our results indicate that CIM-SECDED (1) improves bit error rate (BER) by up to $69.2 \times $ for compute in-memory (2) relaxes the constraints on resistance variations and directly lowers IWV and write voltages. As a result, when applied to AI workloads we achieve (1) 24.4% (29.9%) accuracy improvement on the CIFAR10 (ImageNet) dataset (2) and consequently, improved endurance though lowering write voltage requirements [2].
An Efficient Approach for the Characterization of Mucin‐Type Glycopeptides: The Effect of O‐Glycosylation on the Conformation of Synthetic Mucin Peptides (2011)

Despite the growing importance of mucin core O-glycosylation in many biological processes including the protection of epithelial cell surfaces, the immune response, cell adhesion, inflammation, and tumorigenesis/metastasis, the regulation mechanism and conformational significance of the multiple introduction of α-GalNAc residues by UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases (ppGalNAcTs) remains unclear. Here we report an efficient approach by combining MS and NMR spectroscopy that allows for the identification of O-glycosylation site(s) and the effect of O-glycosylation on the peptide backbone structures during enzymatic mucin domain assembly by using an isoform UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T2 (ppGalNAcT2) in vitro. An electron-capture dissociation device in a linear radio-frequency quadrupole ion trap (RFQ-ECD) combined with a time-of-flight (TOF) mass spectrometer was employed for the identification of Thr/Ser residues occupied by α-GalNAc branching among multiple and potential O-glycosylation sites in the tandem repeats of human mucin glycoproteins MUC4 (Thr-Ser-Ser-Ala-Ser-Thr-Gly-His-Ala-Thr-Pro-Leu-Pro-Val-Thr-Asp) and MUC5AC (Pro-Thr-Thr-Val-Gly-Ser-Thr-Thr-Val-Gly). In the present study, O-glycosylation was initiated specifically at Thr10 in naked MUC4 peptide and additional introduction of α-GalNAc proceeded preferentially but randomly at three other Thr residues to afford densely glycosylated MUC4 containing six α-GalNAc residues at Thr1, Ser2, Ser5, Thr6, Thr10, and Thr15. On the contrary, O-glycosylation of naked MUC5AC peptide occurred predominantly at consecutive Thr residues and led to MUC5AC with four α-GalNAc residues at Thr2, Thr3, Thr7, and Thr8. The solution structures determined by NMR spectroscopic studies elicited that the preferential introduction of α-GalNAc at Thr10 of MUC4 stabilizes specifically a β-like extended backbone structure at this area, whereas other synthetic models with a single α-GalNAc residue at Thr1, Thr6, or Thr15 did not exhibit any converged three-dimensional structure at the proximal peptide moiety. Such conformational impact on the underlying peptides was proved to be remarkable in the glycosylation at the consecutive Thr residues of MUC5AC.
Quick-low-density parity check and dynamic threshold voltage optimization in 1X nm triple-level cell NAND flash memory with comprehensive analysis of endurance, retention-time, and temperature variation (2016)

Abstract NAND flash memory’s reliability degrades with increasing endurance, retention-time and/or temperature. After a comprehensive evaluation of 1X nm triple-level cell (TLC) NAND flash, two highly reliable techniques are proposed. The first proposal, quick low-density parity check (Quick-LDPC), requires only one cell read in order to accurately estimate a bit-error rate (BER) that includes the effects of temperature, write and erase (W/E) cycles and retention-time. As a result, 83% read latency reduction is achieved compared to conventional AEP-LDPC. Also, W/E cycling is extended by 100% compared with conventional Bose–Chaudhuri–Hocquenghem (BCH) error-correcting code (ECC). The second proposal, dynamic threshold voltage optimization (DVO) has two parts, adaptive V Ref shift (AVS) and V TH space control (VSC). AVS reduces read error and latency by adaptively optimizing the reference voltage ( V Ref ) based on temperature, W/E cycles and retention-time. AVS stores the optimal V Ref ’s in a table in order to enable one cell read. VSC further improves AVS by optimizing the voltage margins between V TH states. DVO reduces BER by 80%.
Heterogeneous Integration of a 300-mm Silicon Photonics-CMOS Wafer Stack by Direct Oxide Bonding and Via-Last 3-D Interconnection (2016)

A fully functional Si photonics and 65-nm complementary metal-oxide semiconductor (CMOS) heterogeneous three-dimensional (3-D) integration is demonstrated for the first time in a 300-mm production environment. Direct oxide wafer bonding was developed to eliminate voids between silicon on insulator photonics and bulk Si CMOS wafers. A via-last, Cu through-oxide via 3-D integration was developed for low capacitance electrical connections with no impact on the CMOS performance. The 3-D yield approaching 100% was demonstrated on &amp;gt;20,000 via chains.
Belief Propagation with Side Information for Recovering a Single Community (2018)

In this paper, we study the effect of side information on the recovery of a hidden community of size K inside a graph consisting of n nodes with K=o(n). We focus on side information with finite cardinality and bounded (as n→ ∝) log-likelihood ratios (LLRs). We calculate tight necessary and sufficient conditions for weak recovery of the labels subject to observation of the graph and side information under belief propagation (BP). Also, we show that BP with side information is strictly inferior to the maximum likelihood detector without side information. Finally, we validate our results through simulations on finite synthetic data-sets that shows the power of our asymptotic results in characterizing the performance even at finite n.
A vesicular stomatitis virus glycoprotein epitope-incorporated oncolytic adenovirus overcomes CAR-dependency and shows markedly enhanced cancer cell killing and suppression of tumor growth (2015)

Utility of traditional oncolytic adenovirus (Ad) has been limited due to low expression of coxsackie and adenovirus receptor (CAR) in cancer cells which results in poor infectivity of Ads. Here with an aim of improving the efficiency of Ad's entry to the cell, we generated a novel tropism-expanded oncolytic Ad which contains the epitope of vesicular stomatitis virus glycoprotein (VSVG) at the HI-loop of Ad fiber. We generated 9 variants of oncolytic Ads with varying linkers and partial deletion to the fiber. Only one VSVG epitope-incorporated variant, RdB-1L-VSVG, which contains 1 linker and no deletion to fiber, was produced efficiently. Production of 3-dimensionaly stable fiber in RdB-1L-VSVG was confirmed by immunoblot analysis. RdB-1L-VSVG shows a remarkable improvement in cytotoxicity and total viral yield in cancer cells. RdB-1L-VSVG demonstrates enhanced cytotoxicity in cancer cells with subdued CAR-expression as it can be internalized by an alternate pathway. Competition assays with a CAR-specific antibody (Ab) or VSVG receptor, phosphatidyl serine (PS), reveals that cell internalization of RdB-1L-VSVG is mediated by both CAR and PS. Furthermore, treatment with RdB-1L-VSVG significantly enhanced anti-tumor effect in vivo. These studies demonstrate that the strategy to expand oncolytic Ad tropism may significantly improve therapeutic profile for cancer treatment.
SemI2I: Semantically Consistent Image-to-Image Translation for Domain\n Adaptation of Remote Sensing Data (2020)

Although convolutional neural networks have been proven to be an effective\ntool to generate high quality maps from remote sensing images, their\nperformance significantly deteriorates when there exists a large domain shift\nbetween training and test data. To address this issue, we propose a new data\naugmentation approach that transfers the style of test data to training data\nusing generative adversarial networks. Our semantic segmentation framework\nconsists in first training a U-net from the real training data and then\nfine-tuning it on the test stylized fake training data generated by the\nproposed approach. Our experimental results prove that our framework\noutperforms the existing domain adaptation methods.\n
ChemInform Abstract: Synthesis of gem‐Difluorinated 1,6‐Naphthyridine‐5,7‐diones. (2013)

Abstract A copper‐mediated cross‐coupling of difluoroacetate (II) with haloarenes followed by hydrolysis of the nitrile group/cyclization gives access to title compounds.
Global Transcript Profiles of Fat in Monozygotic Twins Discordant for BMI: Pathways behind Acquired Obesity (2008)

Our findings emphasize a substantial role of mitochondrial energy- and amino acid metabolism in obesity and development of insulin resistance.
Data from Unbiased Metabolic Profiling Predicts Sensitivity of High MYC-Expressing Atypical Teratoid/Rhabdoid Tumors to Glutamine Inhibition with 6-Diazo-5-Oxo-L-Norleucine (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Atypical teratoid/rhabdoid tumors (AT/RT) are aggressive infantile brain tumors with poor survival. Recent advancements have highlighted significant molecular heterogeneity in AT/RT with an aggressive subgroup featuring overexpression of the &lt;i&gt;MYC&lt;/i&gt; proto-oncogene. We perform the first comprehensive metabolic profiling of patient-derived AT/RT cell lines to identify therapeutic susceptibilities in high MYC-expressing AT/RT.&lt;/p&gt;Experimental Design:&lt;p&gt;Metabolites were extracted from AT/RT cell lines and separated in ultra-high performance liquid chromatography mass spectrometry. Glutamine metabolic inhibition with 6-diazo-5-oxo-L-norleucine (DON) was tested with growth and cell death assays and survival studies in orthotopic mouse models of AT/RT. Metabolic flux analysis was completed to identify combination therapies to act synergistically to improve survival in high MYC AT/RT.&lt;/p&gt;Results:&lt;p&gt;Unbiased metabolic profiling of AT/RT cell models identified a unique dependence of high MYC AT/RT on glutamine for survival. The glutamine analogue, DON, selectively targeted high MYC cell lines, slowing cell growth, inducing apoptosis, and extending survival in orthotopic mouse models of AT/RT. Metabolic flux experiments with isotopically labeled glutamine revealed DON inhibition of glutathione (GSH) synthesis. DON combined with carboplatin further slowed cell growth, induced apoptosis, and extended survival in orthotopic mouse models of high MYC AT/RT.&lt;/p&gt;Conclusions:&lt;p&gt;Unbiased metabolic profiling of AT/RT identified susceptibility of high MYC AT/RT to glutamine metabolic inhibition with DON therapy. DON inhibited glutamine-dependent synthesis of GSH and synergized with carboplatin to extend survival in high MYC AT/RT. These findings can rapidly translate into new clinical trials to improve survival in high MYC AT/RT.&lt;/p&gt;&lt;/div&gt;
Substituted 2-azaspiro[5.3]nonan-1-ones as potent cholesterol absorption inhibitors: defining a binding conformation for SCH 48461 (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSubstituted 2-azaspiro[5.3]nonan-1-ones as potent cholesterol absorption inhibitors: defining a binding conformation for SCH 48461Sundeep Dugar, John W. Clader, Tze-Ming Chan, and Harry Davis Jr.Cite this: J. Med. Chem. 1995, 38, 25, 4875–4877Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December 1995https://doi.org/10.1021/jm00025a002RIGHTS & PERMISSIONSArticle Views150Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (333 KB) Get e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information Get e-Alerts
High‐Speed and Low‐Energy Actuation for Pneumatic Soft Robots with Internal Exhaust Air Recirculation (2023)

Multichamber soft pneumatic actuators (m‐SPAs) are widely used in soft robotic systems to achieve versatile grasping and locomotion. However, existing m‐SPAs have slow actuation speed and are either limited by a finite air supply or require energy‐consuming hardware to continuously supply compressed air. Herein, these shortcomings by introducing an internal exhaust air recirculation (IEAR) mechanism for high‐speed and low‐energy actuation of m‐SPAs are addressed. This mechanism recirculates the exhaust compressed air and recovers the energy by harnessing the rhythmic actuation of multiple chambers. A theoretical model to guide the analysis of the IEAR mechanism, which agrees well with the experimental results, is developed. Comparative experimental results of several sets of m‐SPAs show that the IEAR mechanism significantly improves the actuation speed by more than 82.4% and reduces the energy consumption per cycle by more than 47.7% under typical conditions. The promising applications of the IEAR mechanism in various pneumatic soft machines and robots such as a robotic fin, fabric‐based finger, and quadruped robot are further demonstrated. An interactive preprint version of the article can be found at: https://doi.org/10.22541/au.166428178.80668101/v1 .
Appendix A: Nomenclature (2008)

elk eV Avogadro 's number (atoms/mole) atomic mass unit velocity of light electron charge gravitational acceleration Boltzmann's constant electron mass proton mass electron charge-to-mass ratio protron-to-electron mass ratio mass of a xenon atom permittivity of free space permeability of free space atomic cross section temperature associated with 1 electron volt energy associated with 1 electron volt 6.02214179 x loz3 1.6602176487 x ~O -* ~ kg 2.9979 x 10' d s 2 1.602176487 x C 9.
A model predictive control approach for combined braking and steering in autonomous vehicles (2007)

In this paper we present a Model Predictive Control (MPC) approach for combined braking and steering systems in autonomous vehicles. We start from the result presented in F. Borrelli et al. (2005) and P. Falcone et al. (2006), where a Model Predictive Controller (MPC) for autonomous steering systems has been presented. We formulate a predictive control problem in order to best follow a given path by controlling the front steering angle and the brakes at the four wheels independently, while fulfilling various physical and design constraints.
Softening of fused-silica capillaries during particle packing (2000)

When a semipreparative capillary electrochromatography (CEC) capillary is packed with silica particles and exposed to solvent, its mechanical strength is markedly reduced. In our studies, a fused-silica capillary (internal diameter > 200 microm and wall thickness < 150 microm) was packed under pressure (approximately 200 psi) with spherical silica particles (1.5-5 microm) suspended in water or various common organic solvents. After one hour of exposure, the capillary can be readily deformed, and it keeps its deformed shape upon release of the force causing deformation. It is suggested that capillary softening is promoted through the propagation of internal microcracks that have been caused by action of the particles during packing in the presence of solvent. Application of a protective coating to the inside of the capillary is found to reduce or eliminate capillary softening.
A Reduced-PAR Opportunistic STBC Scheme for Frequency-Selective Channels in the Presence of Frequency Offset (2008)

Opportunistic space-time block codes (STBC) have been investigated for flat-fading channels in the literature. In this paper, we present a novel scheme for integrating them with orthogonal frequency division multiplexing (OFDM) for frequency-selective channels with an unequal error protection capability making it attractive for multimedia and multicasting applications. In addition, our new scheme optimizes the tradeoff between coding gain and peak-to-average ratio (PAR) while minimizing inter-carrier interference in the presence of carrier frequency offset. We show that our scheme achieves a 2 dB reduction in PAR over the conventional scheme.
Desarrollo, optimización y validación de un método de análisis para la determinación de etanotiol en Gas Licuado de Petróleo (GLP) mediante cromatografía de gases acoplado a un detector de masas (GC-MS) (2016)

Tesis (licenciatura en quimica)--Universidad de Costa Rica. Facultad de Ciencias Basicas, Escuela de Quimica, 2016
Search for production of vector-like quark pairs and of four top quarks in the lepton-plus-jets final state in pp collisions at s = 8 $$ \sqrt{s}=8 $$ TeV with the ATLAS detector (2015)

A search for pair production of vector-like quarks, both up-type (T ) and downtype (B), as well as for four-top-quark production, is presented. The search is based on pp collisions at s = 8 TeV recorded in 2012 with the ATLAS detector at the CERN Large Hadron Collider and corresponding to an integrated luminosity of 20.3 fb -1 . Data are analysed in the lepton-plus-jets final state, characterised by an isolated electron or muon with high transverse momentum, large missing transverse momentum and multiple jets. Dedicated analyses are performed targeting three cases: a T quark with significant branching ratio to a W boson and a b-quark (T T W b+X), and both a T quark and a B quark with significant branching ratio to a Higgs boson and a third-generation quark (T T Ht+X and B B Hb+X respectively). No significant excess of events above the Standard Model expectation is observed, and 95% CL lower limits are derived on the masses of the vector-like T and B quarks under several branching ratio hypotheses assuming contributions from T W b, Zt, Ht and B W t, Zb, Hb decays. The 95% CL observed lower limits on the T quark mass range between 715 GeV and 950 GeV for all possible values of the branching ratios into the three decay modes, and are the most stringent constraints to date. Additionally, the most restrictive upper bounds on four-top-quark production are set in a number of new physics scenarios.
Hybrid polarizing solids for pure hyperpolarized liquids through dissolution dynamic nuclear polarization (2014)

Hyperpolarization of substrates for magnetic resonance spectroscopy (MRS) and imaging (MRI) by dissolution dynamic nuclear polarization (D-DNP) usually involves saturating the ESR transitions of polarizing agents (PAs; e.g., persistent radicals embedded in frozen glassy matrices). This approach has shown enormous potential to achieve greatly enhanced nuclear spin polarization, but the presence of PAs and/or glassing agents in the sample after dissolution can raise concerns for in vivo MRI applications, such as perturbing molecular interactions, and may induce the erosion of hyperpolarization in spectroscopy and MRI. We show that D-DNP can be performed efficiently with hybrid polarizing solids (HYPSOs) with 2,2,6,6-tetramethyl-piperidine-1-oxyl radicals incorporated in a mesostructured silica material and homogeneously distributed along its pore channels. The powder is wetted with a solution containing molecules of interest (for example, metabolites for MRS or MRI) to fill the pore channels (incipient wetness impregnation), and DNP is performed at low temperatures in a very efficient manner. This approach allows high polarization without the need for glass-forming agents and is applicable to a broad range of substrates, including peptides and metabolites. During dissolution, HYPSO is physically retained by simple filtration in the cryostat of the DNP polarizer, and a pure hyperpolarized solution is collected within a few seconds. The resulting solution contains the pure substrate, is free from any paramagnetic or other pollutants, and is ready for in vivo infusion.