gebhart/patrepeval huggingface dataset:
Multi-objective Inverse Design of Solid-state Quantum Emitter Single-photon Sources (2022)

Single solid-state quantum emitters offer considerable potential for the implementation of sources of indistinguishable single-photons, which are central to many photonic quantum information systems. Nanophotonic geometry optimization with multiple performance metrics is imperative to convert a bare quantum emitter into a single-photon source that approaches the necessary levels of purity, indistinguishability, and brightness for quantum photonics. We present an inverse design methodology that simultaneously targets two important figures-of-merit for high-performance quantum light sources: the Purcell radiative rate enhancement and the coupling efficiency into a desired light collection channel. We explicitly address geometry-dependent power emission, a critical but often overlooked aspect of gradient-based optimization of quantum emitter single-photon sources. We illustrate the efficacy of our method through the design of a single-photon source based on a quantum emitter in a GaAs nanophotonic structure that provides a Purcell factor $F_p=21$ with a 94% waveguide coupling efficiency, while respecting a geometric constraint to minimize emitter decoherence by etched sidewalls. Our results indicate that multi-objective inverse design can yield competitive performance with more favorable trade-offs than conventional approaches based on pre-established waveguide or cavity geometries.
THE IMPACT OF MOTHER’S BEHAVIOR ON INFANT’S SLEEP BEFORE AND AFTER SURGICAL INTERVENTION FOR CLEFT-LIP-PALATE (CLP) REPAIR (2008)

Objectives Next to cardiovascular and genitourinary malformations, CLP is the most common congenital defect demanding surgical repair. In Europe about one in 700 births is affected by a CLP malformation. The commonplace view is that any surgical intervention in young infants leads to heightened psychological and physiological stress in both infants and parents. However, reliable data are missing. Furthermore, if the surgical intervention was a stressful event, this should be mirrored in changes to the child’s sleep continuity. The aim of the study was therefore to assess sleep of infants with CLP before and after CLP repair, and to compare these sleep patterns descriptively with the mother’s sleep pattern. Methods The sleep of seven infants with CLP was assessed by means of actigraphy four days before and four days after surgical intervention for CLP repair. Additionally, mothers completed a sleep log for the same period of time. Results No statistically significant differences between infants’ sleep before and after surgical intervention were observed. Infants’ sleep duration decreased markedly the night before the surgical intervention. Mother’s sleep quality decreased preceding the day of the CLP repair, and sleep onset latency almost doubled. Conclusions CLP repair is not as ‘traumatic’ as the commonplace view holds, because otherwise infants sleep patterns would have been much more altered. However, comparing the patterns of mother’s and infant’s sleep suggests that infants are sensitive to their mother’s psychological tension and behavior. As a result, infants may become concerned, and this tension is reflected in reduced sleep.
Integrated closed-loop cavity of a tunable laser (2016)

In this paper, a closed-loop cavity of a tunable laser integrated onto a silicon chip is demonstrated. The closed-loop cavity consists of a semiconductor optical amplifier chip, two separated micro-ring resonators, and a U-shaped waveguide sub-loop, enabling dominating lasing in the counterclockwise direction. The lasing wavelength is tuned by varying the effective refractive index of the thermal ring-resonators. It has achieved wide tuning range (55.4 nm), high spectral purity (50-dB side mode suppression ratio), ∼1-mW output power, and 36-dB counter-propagation power suppression ratio. The integrated tunable laser has high potential in applications such as optical network, optical sensing, and integrated optoelectronic systems.
Supplementary Tables 1 through 4 and Supplementary Figures 1 through 5 from <i>In Vitro</i> and <i>In Vivo</i> Characterization of Irreversible Mutant-Selective EGFR Inhibitors That Are Wild-Type Sparing (2023)

&lt;p&gt;PDF - 252K, Supplemental Table 1. Mass spectrometry on EGFR-L858R/T790M protein. Supplemental Table 2. EGFR modulation in A431, H1975 and HCC827 cells by compound 3. Supplemental Table 3. Kinase selectivity profile of compound 3, afatinib and WZ4002 at 1 ?M. Supplemental Table 4.Multi-dose level PK/PD study in H1975 tumor-bearing mice. Supplemental Figure 1. Signaling inhibition in EGFR wild-type (A431) and mutant EGFR NSCLC cells (H1975 and HCC827). Supplemental Figure 2. Prolonged duration of action on EGFR-L858R/T790M (A) and EGFR-DelE746-A750 (B) proteins. Supplemental Figure 3. Protein degradation (t1/2) of EGFR-L858R/T790M (A) and EGFR-DelE746-A750 (B) in H1975 and HCC827 cells, respectively. Supplemental Figure 4. Prolonged duration of action on EGFR-DelE746-A750 protein by erlotinib. Supplemental Figure 5. Time-dependent inhibition in EGFR mutant H1975 (A) and HCC827 (B) cells.&lt;/p&gt;
Planning and Pricing of Service Mashups (2008)

Today's development and provision of commercially used Web services has shifted from providing static and predefined functionality to highly configurable services that can be dynamically combined by customers. This new form of composed services called service mashups integrate functionality of multiple sub-services from decentralized providers. Consequently this leads to a high configuration complexity and presents new challenges in the field of planning and pricing of service offerings such as validation of service configurations as well as price determination. Facing these challenges this paper presents an ontology framework for describing technical as well as economic interdependencies between services and shows how planning and pricing algorithms for dynamic Web scenarios can be implemented. As proof of concept we present the implementation of a service mashup planner and show how this tool can be used to construct complex services considering technical as well as economic service aspects.
ChemInform Abstract: Structural and Vibrational Characteristics of the Tetrasulfatodimolybdenum Ions with Mo‐Mo Bond Orders of 3.5 and 4.0. (1988)

Abstract The compound (III), prepared as shown in the scheme (yield in g), crystallizes in the tetragonal space group P4/mnc and is isostructural with the analogous chloride compound, whose structure has been published.
ChemInform Abstract: 1,3‐DIETHOXYCARBONYLALLENE‐ AN ACTIVE DIENOPHILE AND ETHOXYCARBONYLKETENE EQUIVALENT IN THE SYNTHESIS OF ANTIBIOTIC C‐NUCLEOSIDES (1978)

Abstract Das Allen (I) liefert mit 3‐Hydroxy‐2‐pyron oder Cyclopentadien die Cycloaddukte (IIIa) bzw. (IIIb), von denen (IIIa) mit Bortrifluorid in Dichlormethan zum Phenol (IV) isomerisiert wird.
Deep Activation Mixture Model for Speech Recognition (2017)

Deep learning approaches achieve state-of-the-art performance in a range of applications, including speech recognition.However, the parameters of the deep neural network (DNN) are hard to interpret, which makes regularisation and adaptation to speaker or acoustic conditions challenging.This paper proposes the deep activation mixture model (DAMM) to address these problems.The output of one hidden layer is modelled as the sum of a mixture and residual models.The mixture model forms an activation function contour while the residual one models fluctuations around the contour.The use of the mixture model gives two advantages: First, it introduces a novel regularisation on the DNN.Second, it allows novel adaptation schemes.The proposed approach is evaluated on a large-vocabulary U.S. English broadcast news task.It yields a slightly better performance than the DNN baselines, and on the utterance-level unsupervised adaptation, the adapted DAMM acquires further performance gains.
An actin-binding protein, CAP, is expressed in a subset of rat taste bud cells (2001)

Single cell cDNA libraries were constructed from taste bud cells of rat circumvallate papillae. Using three steps of screening, including differential hybridization, sequence analyses and in situ hybridization, a clone encoding a rat homolog of yeast adenylyl cyclase-associated protein (CAP) was identified to be highly expressed in a subset of taste bud cells.
Towards Enterprise-Ready AI Deployments Minimizing the Risk of Consuming\n AI Models in Business Applications (2019)

The stochastic nature of artificial intelligence (AI) models introduces risk\nto business applications that use AI models without careful consideration. This\npaper offers an approach to use AI techniques to gain insights on the usage of\nthe AI models and control how they are deployed to a production application.\n Keywords: artificial intelligence (AI), machine learning, microservices,\nbusiness process\n
Functionalized Organosilicate Sorbents for Air Purification (2013)

Abstract : A program was initiated in June 2009 to evaluate the potential of porous organosilicate sorbents in the capture or neutralization of light gas threats. Of primary interest were targets identified by the TIC/TIM Task Force as priority threats. A number of approaches were taken for increasing binding capacity and reactivity in the sorbent materials: grafting of metalloporphyrins, incorporation of sites for metal coordination, and incorporation of acidic and basic groups. In addition, the impact of morphological considerations, such as pore size and organization, were evaluated. Target capture by the sorbents was evaluated using microbreakthrough testing completed at the Edgewood Chemical Biological Center. Development of relevant sorbent morphologies was also pursued. Overall, the sorbents show promise, with several offering improvements in target capture and retention over state-of-the-art materials.
Clinical translation of noninvasive intracranial pressure sensing with diffuse correlation spectroscopy (2022)

The authors have shown that DCS may enable ICP monitoring with additional clinical validation. The lower risk of such monitoring would allow ICP to be estimated for a wide spectrum of indications, thereby both reducing the use of invasive monitors and increasing the types of patients who may benefit from ICP-directed therapies.
Stereoselective hydrogen-transfer reactions involving acyclic radicals. A study of radical conformations using semiempirical calculations (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereoselective hydrogen-transfer reactions involving acyclic radicals. A study of radical conformations using semiempirical calculationsK. Durkin, D. Liotta, J. Rancourt, J. F. Lavallee, L. Boisvert, and Y. GuindonCite this: J. Am. Chem. Soc. 1992, 114, 12, 4912–4914Publication Date (Print):June 1, 1992Publication History Published online1 May 2002Published inissue 1 June 1992https://pubs.acs.org/doi/10.1021/ja00038a072https://doi.org/10.1021/ja00038a072research-articleACS PublicationsRequest reuse permissionsArticle Views175Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Use of localized canonical solutions of the Hartree--Fock equations in many- body perturbation theory (1975)

The existence of localized canonical solutions of the Hartree--Fock equations is investigated. Application of a prescription proposed by Davidson provides the modification needed to settle the difficulties investigated by Brandow in the context of the theory of solid $sup 3$He.
Syntheses, Structures, Physical Properties, and Theoretical Studies of CeMxOS (M: Cu, Ag; x ≈ 0.8) and CeAgOS. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Abstract 2902: A simple blood test, evaluating the level of CD24 protein, can detect subjects with colorectal adenomas and adenocarcinomas (2010)

Abstract Background: CD24 is a cell surface protein involved in cell adhesion and metastasis. Using gene expression array we have shown that CD24 expression is associated with colorectal cancer (CRC) [1,2]. The data was confirmed by IHC staining showing expression of CD24 in ∼90% of CR adenomas and adenocarcinomas. Two genetic variants of CD24, a C to T single nucleotide polymorphism (SNP), leading to an Ala/Val exchange (A57V) and a TG deletion in the 3’-UTR have been described, may have functional relevance, and affect CD24 protein level and stability. Objectives: To evaluate CD24 protein expression in peripheral blood leukocytes (PBLs) from normal, adenoma and CRC subjects, and score the associations of CD24 genetic variants and CRC risk. Methods: The calibration trial included 150 consented subjects (CRC=63, Adenomas=19, Normal=68) attending Tel Aviv Medical Center that underwent colonoscopy. PBLs were isolated and analyzed by Western blotting using anti-CD24. The samples were externally evaluated at the Technion, Haifa. The validation trial included 73 subjects. Additional 83 subjects were recently examined. Band intensities were scanned and tested for statistical significance. Sensitivity and specificity for CD24 was determined using receiver operating characteristic (ROC) curves. The study was approved by the Israel Ministry of Health. Results: The sensitivity and specificity of the CD24 test for distinguishing CRC from normal subjects was 70.5% (95% CI, 54.8-83.2%) and 83.8% (95% CI, 74.6-92.7%), respectively, and for advanced adenomas 84.2% (95% CI, 60.4-96.4%) and 73.5% (95% CI, 61.4-83.5%), respectively. The external evaluation study varied slightly. Improved values were achieved in the validation trial. Thus, the sensitivity for the detection of CRC was 92.3% (95% CI, 63.9-98.7%), with similar specificity, whereas the specificity for detecting adenomas was higher, 89.2% (95% CI, 74.6-96.9%). No significant correlations were found between the expression of CD24 and the two SNPs examined. However, preliminary data shows that the P170 C/T variant may increase susceptibility to CR adenomas (p=0.048) while the TG/del CD24 SNP may have a protective role (NS). Conclusions: The CD24 blood test is the first of its kind to be able to detect adenomas. It can also successfully distinguish CRC from healthy subjects. CD24 may serve as a potential and promising biomarker for the early detection of CRC. Larger studies are warranted to establish the future potential of this promising test. References: 1. Sagiv E., Gastroenterology 2006 2. Sagiv E., Can Res, 2008 Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2902.
Interactive intent-based illustration: a visual language for three-dimensional worlds (1993)

The objective of this work is to devise a scheme for effective visual communication. A visual presentation can be designed to solve communicative intent; that is, both convey what we want to communicate as well as elicit, from our audience, a desired action or interpretation. In this thesis we define a visual language and a methodology for its use to both design and generate automatically 3D graphics that fulfill a specified communicative intent.
The visual language we have defined is used to capture the full cycle of communication: Given specific communicative goals, the system begins to create an illustration by choosing sets of visual effects that, in turn, specify the parameters that define a computer-generated picture. The system then examines the picture to determine if each effect is achieved, and thus evaluates how well each communicative goal is achieved. Our visual language represents an illustration on three levels: what is being conveyed, what visual effects are used, how these visual effects are achieved. Thus, we separate design or the set of visual effects selected to satisfy communicative goals, from style, or how each visual effect is accomplished.
Computer graphics need not be static; we have exploited the dynamism of the system to support four different types of interactivity: user-navigation, changing goals, changing worlds, and self-evaluation. During all phases of interaction, the illustration remains bound to the (possible changing) communicative intent, modifying the illustration to achieve violated goals. We have implemented IBIS as proof-of-concept for our ideas. IBIS generates illustrations that explain the use, maintenance and repair of objects. IBIS generates fully shaded 3D graphics that are displayed on a high resolution display for a multimedia explanation system and IBIS also generates overlaid 3D bi-level illustrations that are projected on a see-through head-mounted display that appear over the user's view of the world for an augmented reality system.
Hepsin overexpression promotes tumor growth in an orthotopic prostate cancer model (2007)

AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA

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Hepsin, a type II transmembrane serine protease, is highly upregulated in prostate cancer. Hepsin promotes tumor metastasis in a mouse model of prostate cancer, suggesting a role in the later tumor stages. However, hepsin protein levels are already high in pre-cancerous lesions and remain elevated in the carcinoma and metastasis stages. In this study, we investigated the role of hepsin in primary tumor growth in an orthotopic prostate cancer model by use of hepsin-transfected LnCaP cell lines, which also stably expressed luciferase for bioluminescence imaging. The LnCaP-34 cells stably expressed hepsin protein on the cell surface at about 5-fold higher levels than the LnCaP-17 cells, which only expressed endogenous hepsin. The higher hepsin levels on LnCaP-34 correlated with increased hepsin enzymatic activity towards pro-urokinase type plasminogen activator. 1x106 LnCaP-17 or LnCaP-34 cells were injected into the left anterior lobe of the prostate of SCID-beige mice (20 animals per group) and tumors were analyzed after 16 weeks. We found a higher tumor occurrence (80% vs 58%) and lower body weights (20.8±0.8g vs. 23.5±0.9g; p<0.05) in the LnCaP-34 group compared to the LnCaP-17 group. In addition, animals of the LnCaP-34 group had 2.4-fold higher normalized prostate tissue weights and larger tumors than the LnCaP-17 group (tumor wet weights of 2.12±0.22g and 1.20±0.27g, respectively; p<0.02). Most strikingly, histological examination revealed that the LnCaP-17 tumors were confined to the left anterior lobe of the prostate (7/7 animals), i.e. the lobe where tumor cells were injected at the start of the study, whereas the LnCaP-34 tumors had spread from the left to the right anterior lobes (7/7 animals). These results suggested that hepsin overexpression endowed LnCaP-34 cells with increased invasive capacity concomitant with enhanced tumor growth. Moreover, the in-vitro proliferation rates of LnCaP-17 and LnCaP-34 cells were identical, indicating that the prostate microenvironment was important in mediating the hepsin-driven tumor growth. Unlike the differences in primary tumor growth, the occurrence of lung metastatic lesions as determined by ex-vivo bioluminescence imaging was similar in the LnCaP-17 and LnCaP-34 groups (50% vs 44%). This is in agreement with the presence of numerous tumor cell infiltrates in the tumor vasculature in both groups. However, lymph node metastasis was increased in the LnCaP-34 animals (22% vs 0% in LnCaP-17 animals), based on periaortic lymph node bioluminescence imaging at the time of tissue harvest. In conclusion, the finding that hepsin overexpression enhances invasive tumor growth suggests that elevated hepsin expression in pre-cancerous lesions and in prostate carcinoma may contribute to tumor invasiveness and growth.
Stretchable Optical Waveguide Sensor Capable of Two-Degree-of-Freedom Strain Sensing Mediated by a Semidivided Optical Core (2022)

With the rising demand for flexible strain sensors for soft robots, optical sensing solutions have been proven to be electrically safe, stable, and precise. This study presents a highly stretchable optical waveguide sensor that extends existing solutions to two degrees of freedom while maintaining low manufacturing complexity and part count. Through casting in a 3D-printed mold, a polymer waveguide is manufactured, featuring a semidivided core cross section. The light from a near-infrared LED light source is guided to two phototransistors connected to each chamber. The connection between both core chambers makes the power throughput amplitude and ratio at the two outputs dependent on the strain amplitude as well as its location or direction. The proposed waveguide is experimentally compared with single and dual core designs in four different strain modes, to sense elongation, local deformation amplitude and position across length, twisting angle and direction, as well as bending amplitude and direction in a soft finger. While influences of the manual manufacturing process are apparent, the results verify that the presented waveguide sensor can be effectively applied in these four strain scenarios. We also demonstrate that information about superimposed strain states can be obtained from the time signal.
Transcriptomic analysis reveals the gene regulatory networks involved in leaf and root response to osmotic stress in tomato (2023)

This work shed new light on the regulatory networks occurring in tomato leaf and root under osmotic stress and set the base for an in-depth characterization of novel stress-related genes that may represent potential candidates for improving tolerance to abiotic stress in tomato.
Integrated Kerr Comb Link with Multi-Channel DWDM Silicon Photonic Receiver (2022)

We demonstrate an error free silicon photonic receiver of a frequency-comb at 16Gb/s/ λ that is the first to de-multiplex channels on-chip. These results pave the way to massively parallel links with chip-scale combs and transceivers.
Observation of the B[superscript +] → D[superscript ∗] − K[superscript +] π[superscript +] decay (2017)

The B[superscript +]→D[superscript *-]K[superscript +]π[superscript +] decay potentially provides an excellent way to investigate charm meson spectroscopy. The decay is searched for in a sample of proton-proton collision data collected with the LHCb detector at center-of-mass energies of 7 and 8 TeV, corresponding to an integrated luminosity of 3 fb[superscript -1]. A clear signal is observed, and the ratio of its branching fraction to that of the B[superscript +]→D[superscript *-]π[superscript +]π[superscript +] normalization channel is measured to be B(B[superscript +]→D[superscript *-]K[superscript +]π[superscript +])/B(B[superscript +]→[superscript *-]π[superscript +]π[superscript +])=(6.39±0.27±0.48)×10[superscript -2], where the first uncertainty is statistical and the second is systematic. This is the first observation of the B[superscript +]→D[superscript *-]K[superscript +]π[superscript +] decay.