gebhart/patrepeval huggingface dataset:
Real-time Video Mosaicing using Non-rigid Registration (2012)

This paper presents a real-time incremental mosaicing method that generates a large seamless 2D image by stitching video key-frames as soon as they are detected. There are four main contributions: (1) we propose a “fast” key-frame selection procedure based solely on the distribution of the distance of matched feature descriptors. This procedure automatically selects key-frames that are used to expand the mosaics while achieving real-time performance; (2) we register key-frame images by using a non-rigid deformation model based on a triangular mesh in order to “smoothly” stitch images when scene transformations can not be expressed by homography; (3) we add a new constraint on the non-rigid deformation model that penalizes over-deformation in order to create mosaics with natural appearance; (4) we propose a fast image stitching algorithm for real-time mosaic rendering modeled as an instance of the minimum graph cut problem, applied to mesh triangles instead of the image pixels. The performance of the proposed method is validated by experiments in non-controlled conditions and by comparison with a state-of-the-art method.
Storing files in a parallel computing system using list-based index to identify replica files (2023)

Improved techniques are provided for storing files in a parallel computing system using a list-based index to identify file replicas. A file and at least one replica of the file are stored in one or more storage nodes of the parallel computing system. An index for the file comprises at least one list comprising a pointer to a storage location of the file and a storage location of the at least one replica of the file. The file comprises one or more of a complete file and one or more sub-files. The index may also comprise a checksum value for one or more of the file and the replica(s) of the file. The checksum value can be evaluated to validate the file and/or the file replica(s). A query can be processed using the list.
Expanding cross-presenting dendritic cells enhances oncolytic virotherapy and is critical for long-term anti-tumor immunity (2022)

Immunotherapies directly enhancing anti-tumor CD8<sup>+</sup> T cell responses have yielded measurable but limited success, highlighting the need for alternatives. Anti-tumor T cell responses critically depend on antigen presenting dendritic cells (DC), and enhancing mobilization, antigen loading and activation of these cells represent an attractive possibility to potentiate T cell based therapies. Here we show that expansion of DCs by Flt3L administration impacts in situ vaccination with oncolytic Newcastle Disease Virus (NDV). Mechanistically, NDV activates DCs and sensitizes them to dying tumor cells through upregulation of dead-cell receptors and synergizes with Flt3L to promote anti-tumor CD8<sup>+</sup> T cell cross-priming. In vivo, Flt3L-NDV in situ vaccination induces parallel amplification of virus- and tumor-specific T cells, including CD8<sup>+</sup> T cells reactive to newly-described neoepitopes, promoting long-term tumor control. Cross-presenting conventional Type 1 DCs are indispensable for the anti-tumor, but not anti-viral, T cell response, and type I IFN-dependent CD4<sup>+</sup> Th1 effector cells contribute to optimal anti-tumor immunity. These data demonstrate that mobilizing DCs to increase tumor antigen cross-presentation improves oncolytic virotherapy and that neoepitope-specific T cells can be induced without individualized, ex vivo manufactured vaccines.
ViBO: VCSEL with integrated backside optics for LiDAR applications (2023)

Flip-chip VCSELs with backside emission and lenses directly etched into the GaAs substrate are the most compact way to integrate optics with the VCSEL (ViBO = VCSEL with integrated Backside Optics). Beam shapes with lens structures enabling collimation as well as the uniform illumination of a defined field of view have been realized. Superior to separate optical elements the integrated optics avoids the need for individual alignment of laser die and optics and makes them an irremovable part of the chip. The realization of both contacts on the epitaxy side enables flip-chip assembly without the need for wire bonds, thus enabling ultra-short pulse operation. VCSELs are preferred for LiDAR applications due to their thermal stability and reliability. The required high brilliance can be achieved by micro-optics. Scaling the power into the kilowatt range requires stacked junctions and multi-chip concepts. This paper presents a new LiDAR system concept exploiting the potential of VCSELs with integrated optics.
Predictor based multiuser and single user detection for time varying frequency selective Rayleigh fading CDMA channels (2002)

Multiuser detection for linearly modulated signals (e.g. asynchronous code division multiple access (CDMA)) sent over a time varying, frequency selective Rayleigh fading channel is considered. The multiuser maximum likelihood sequence detector (MLSD) using linear predictors is derived assuming knowledge of the channel second order statistics only. This receiver is appropriate when there are no pilot tones and the channel's time varying impulse response cannot be accurately estimated. The receiver uses predictors to estimate the received signal and forms a weighted Euclidean distance between the predicted and the received samples. The computational complexity of this receiver grows exponentially with the number of users, hence, we propose an additional single user receiver that is constrained to track and lock to the signal of the desired user, but unlike the conventional single user receiver, it is optimised to take into account the structure of the multiple access interference (MAI). An analysis of the multiuser receiver is also provided. We obtain tight bit error probability bounds using a truncated union bound approach.
The interaction of uPAR with VEGFR2 promotes VEGF-induced angiogenesis (2015)

In endothelial cells, binding of vascular endothelial growth factor (VEGF) to the receptor VEGFR2 activates multiple signaling pathways that trigger processes such as proliferation, survival, and migration that are necessary for angiogenesis. VEGF-bound VEGFR2 becomes internalized, which is a key step in the proangiogenic signal. We showed that the urokinase plasminogen activator receptor (uPAR) interacted with VEGFR2 and described the mechanism by which this interaction mediated VEGF signaling and promoted angiogenesis. Knockdown of uPAR in human umbilical vein endothelial cells (HUVECs) impaired VEGFR2 signaling, and uPAR deficiency in mice prevented VEGF-induced angiogenesis. Upon exposure of HUVECs to VEGF, uPAR recruited the low-density lipoprotein receptor-related protein 1 (LRP-1) to VEGFR2, which induced VEGFR2 internalization. Thus, the uPAR-VEGFR2 interaction is crucial for VEGF signaling in endothelial cells.
Synthesis and antibacterial activity of C-4 substituted monobactams. (1987)

The synthesis and in vitro antibacterial profile of several novel C-4 substituted monobactam analogs are reported.
ChemInform Abstract: The Synthesis and Biological Evaluation of a Novel Series of Antimicrobials of the Oxazolidinone Class. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Compact low-cost tunable acrylate polymer arrayed-waveguidegrating multiplexer (1999)

A compact 16 × 16 channel arrayed-waveguide grating multiplexer with 1.6 nm (200 GHz) channel spacing at 1550 nm has been fabricated using acrylate polymers. The crosstalk is &lt; –25 dB, uniformity is ±0.5 dB and on-chip loss is 7.7 dB. Device sizes as small as 16.5 × 12 mm2 have been achieved.
Privacy Regulations-Aware Storage Service Selection in Multi-Cloud (2023)

Cloud computing involves the dispersal of data across several data centers which could be geographically distributed. The way in which cloud transcends data through national boundaries poses privacy and security threats. In this work, we propose a decision support framework to assist enterprises in cloud storage service selection, taking into consideration varied data regulations such as strict and sectorspecific data localization, and GDPR. We demonstrate the implications of data regulations and data distributions across multiple cloud service providers.
Human Adolescent Nephronophthisis (2001)

In a large Venezuelan kindred, a new type of nephronophthisis was recently identified: Adolescent nephronophthisis (NPH3) is a late-onset recessive renal cystic disorder of the nephronophthisis/medullary cystic group of diseases causing end-stage renal disease at a median age of 19 yr. With the use of a homozygosity mapping strategy, the gene (NPHP3) was previously localized to chromosome 3q22 within a critical interval of 2.4 cM. In the current study, the NPHP3 genetic region was cloned and seven genes, eight expressed sequence-tagged sites, and seven microsatellites were physically localized within the critical disease interval. By human-mouse synteny analysis based on expressed genes, synteny between the human NPHP3 locus on chromosome 3q and the pcy locus on mouse chromosome 9 was clearly demonstrated, thus providing the first evidence of synteny between a human and a spontaneous murine renal cystic disease. By fluorescence in situ hybridization the chromosomal assignment of NPHP3 to chromosome 3q21-q22 was refined. Renal pathology in NPH3 was found to consist of tubular basement membranes changes, tubular atrophy and dilation, and sclerosing tubulointerstitial nephropathy. This pathology clearly resembled findings observed in the recessive pcy mouse model of late-onset polycystic kidney disease. In analogy to pcy, renal cyst development at the corticomedullary junction was found to be an early sign of the disease. Through cloning of the NPH3 critical region and mapping of expressed genes, synteny between human NPH3 and murine pcy was established, thus generating the hypothesis that both diseases are caused by recessive mutations of homologous genes.
Using simulation techniques to prove timing properties (1995)

This thesis presents a methodology based on simulations and invariants for proving timing properties of real-time, distributed systems. This methodology is used to prove tight time bounds for two systems, a leader election protocol for a ring of processes, and Fischer&amp;apos;s timing-based mutual exclusion algorithm. A framework for verifying these proofs using the Larch tools is also developed, and the proof for Fischer&amp;apos;s algorithm is checked within this framework. Many formal methods have been developed for proving the correctness of untimed distributed systems. However, real-time systems often have subtle timing dependencies that are difficult to analyze and reason about. Furthermore, for many real-time systems, correctness is insufficient; it is important to satisfy certain performance requirements. It is necessary, therefore, to extend the formal models and techniques to the timed setting. We use a timed automaton model, together with simulations which establish that one automaton impl...
Voltage-tuned resonant reflectance optical filter for visible wavelengths fabricated by nanoreplica molding (2007)

A guided-mode resonant filter incorporating an electro-optically tunable liquid crystal refractive index is demonstrated at a wavelength of 655nm and a tuning range of 4nm. Rigorous coupled wave analysis and finite difference time domain analysis are used to simulate the characteristics of the filter during liquid crystal reorientation. Tuning performance is demonstrated that is consistent with the device simulations. Tunable filters in the visible wavelength range that are inexpensively fabricated over large surface areas are expected to find applications in optical limiting and video display.
Generalized center of compliance and stiffness (2003)

The elastic characteristics of many robot systems can be modeled by a 6*6 stiffness or compliance matrix. Three results are presented via screw theory. First, stationary values of compliance and stiffness are determined. Second, linear and rotational properties are characterized by dual ellipsoids in three-dimensional space. Third, a generalized center-of-elasticity (compliance and stiffness) is proposed. If a compliant axis exists, it is shown to pass through the center. These elements simplify the understanding of complex elastic properties.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Reliability-Based Maintenance Strategies for Heat Exchangers Subject to Fouling (1996)

Fouling in heat exchangers is an unavoidable by-product of the heat transfer process. The decision regarding periodic maintenance (cleaning) of the exchangers subject to fouling is generally based on thermal and economic behavior of the process. In this paper, a reliability-based maintenance strategy is discussed by incorporating the risk and scatter parameters of the linear random fouling growth model. In addition, the dimensionless cost-objective function is formulated by considering various cost elements for a heat exchanger used in a crude oil preheat train. The variation in the dimensionless cost Γ with reduced time tp/(tp + tdown) is presented for different values of unit cost parameters γ1, γ2, and γ3 representing additional fuel cost, antifoulant cost, and miscellaneous costs, respectively. Furthermore, the optimal cleaning cycle of the heat exchanger recently investigated by Casado (1990) is demonstrated to be a special case of the results presented in the paper.
Development and Performance of Tungsten-Coated Graphitic Foam for Plasma-Facing Components (2019)

High-density graphitic foam is an ideal low-Z plasma-facing material for deuterium-deuterium plasma experiments where tritium codeposition is not an issue. However, like all carbon, graphitic foam suffers from a precipitous drop in thermal conductivity at high temperatures, >600°C. To mitigate these problems, functionally graded layers of tungsten can be deposited to a thickness of 2 to 4 mm onto the plasma side of the foam using chemical vapor deposition. The graphitic foam then acts as a high-conductivity heat sink at temperatures below 600°C for the thin high-Z armor coating. The overall component weighs 18 times less than a comparable volume of tungsten and lacks the coefficient of thermal expansion joining issues between the CuCrZr tubing and the tungsten. This paper discusses the coating development and characterization and presents the results of recent plasma exposures in W7-X. It also reports on computational fluid dynamics heat transfer modeling and preparations for high heat flux testing of mock-ups. This hybrid plasma-facing component (PFC) consisting of innovative engineered materials may be a cost-effective, actively cooled solution for the divertors and other PFCs in long-pulse machines like W7-X and WEST.
Inhibition of Human Glutathione Reductase by 10-Arylisoalloxazines:  Crystallographic, Kinetic, and Electrochemical Studies (1996)

A series of newly synthesized N(10)-arylisoalloxazines--some of which are known to be antimalarial agents--were studied as inhibitors of human glutathione reductase (GR;NADPH + GSSG + H(+) <==> NADP(+) + 2GSH). The flavoenzyme was inhibited with IC(50) values between </- 1 and 100 microM in the presence of 100 microM NADPH. The isoalloxazines and N(3)-methylisoalloxazines with a 4'-chlorophenyl or a 3',5'-dichlorophenyl group at N10 were found to be the most promising inhibitors of GR, although even the bulkier 10-naphthyl and -anthryl derivatives were also effective inhibitors. In contrast, at position N3 of the isoalloxazine ring, the size of the substituent was found to strongly influence the inhibitory effect. Introduction of a carboxymethyl group at N3--which markedly increased the solubility of the derivative in aqueous solutions-- caused a rise in the IC(50) values by 1 order of magnitude. 8-Fluoro- and 8-azido-10-arylisoalloxazines were potent inhibitors of GR; consequently position C8 of the benzenoid subnucleus instead of N3 should be considered for introducing substituents. No correlation was observed between the inhibitory strength of several isoalloxazines and their redox potential as measured by cyclovoltammetry. The crystallographic analysis of GR complexed with 10-(4'-chlorophenyl)-3-(carboxymethyl)isoalloxazine and 10-(3',5'-dichlorophenyl)-3-(carboxymethyl)isoalloxazine, respectively, revealed the presence of one inhibitor molecule bound at the 2-fold axis of the homodimeric protein. This location is consistent with fluorescence titration measurements and enzyme kinetic studies in solution which gave no indication for binding at the substrate sites.
A Neural Network Predictor of Lumbar Fusion Surgery Outcomes (2001)

This work illustrates the potential utility of neural networks as a decision support tool for predicting long-term outcomes of elective lumbar fusion for chronic low back pain. Sixty variables were collected on each of 79 patients who had undergone elective lumbar fusion and had at least one year follow-up. A ten fold cross-validated training and test set were randomly created that demonstrated an R2 = 0.98 and 0.89 respectively. A traditional linear regression analysis resulted in an R2= 0.28. This neural network model should allow better patient selection for this very unpredictable and expensive surgery.
Chromosome X-encoded cancer/testis antigens show distinctive expression patterns in developing gonads and in testicular seminoma (2011)

Most CT-X antigens are expressed in human fetal germ cells after they have lost stem cell characteristics, with predominant expression in pre-meiotic germ cells. Spermatocytic seminomas showed expression of all CT-X antigens except SPANX, whereas classical seminomas only express some CT-X antigens, reflecting their different origins from adult versus fetal germ cells.
State-space models for infinite-dimensional systems (1974)

Distributed effects are present in almost all physical systems. In some cases these can be safely ignored but there are many interesting problems where these effects must be taken into account. Most infinite dimensional systems which are important in control theory are specifiable in terms of a finite number of parameters and hence are, in principle, amenable to identification. The state-space theory of infinite dimensional systems has advanced greatly in the last few years and is now at a point where real applications can be contemplated. The realizability criteria provided by this work can be employed effectively in the first step of the identification procedure, i.e., in the selection of an appropriate infinite dimensional model. We show that there exists a natural classification of nonrational transfer functions, which is based on the character of their singularities. This classification has important implications for the problem of finite dimensional approximations of infinite dimensional systems. In addition, it reveals the class of transfer functions for which there exist models with spectral properties closely reflecting the properties of the singularities of the transfer functions. The study of models with infinitesimal generators having a connected resolvent sheds light on some open problems in classical frequency response methods. Finally, the methods used here allow one to see the finite dimensional theory itself more clearly as the result of placing it in the context of a larger theory.
Multifunctional Hybrid Nanopatches of Graphene Oxide and Gold Nanostars for Ultraefficient Photothermal Cancer Therapy (2014)

Multifunctional hybrid nanomaterials with enhanced therapeutic efficiency at physiologically safe dosages for externally triggered, image-guided therapy are highly attractive for nanomedicine. Here, we demonstrate a novel class of multifunctional hybrid nanopatches comprised of graphene oxide (GO) and gold nanostars for enhanced photothermal effect and image-guided therapy. The hybrid nanopatches with tunable localized surface plasmon resonance into the near-infrared therapeutic window (650-900 nm) were realized using a biofriendly method that obviates the need for toxic shape-directing agents. Internalization of the intact nanopatches into epithelial breast cancer cells was confirmed by Raman imaging, transmission electron microscopy, and inductively coupled plasma mass spectrometry. It appears that the amphipathic nature and the large surface area of the graphene oxide enable it to serve as a soft, flexible, and biocompatible intracellular carrier for the in situ grown plasmonic nanostructures and provide long-term biocompatibility with extremely low cytotoxicity. Apart from a remarkably improved photothermal effect compared to that of either of the components at very low dosages of the hybrids (10 μg/mL GO) and using a low laser power (0.75 W cm(-2)), the hybrid nanopatches exhibit strong Raman scattering, making them excellent candidates for bioimaging, diagnostics, and image-guided therapy applications.
Pulsed-Field Electrophoresis of Megabase-Sized DNA (1991)

Success in constructing a physical map of the human genome will depend on two capabilities: rapid resolution of very large DNA and identification of migration anomalies. To address these issues, a systematic exploration of pulsed-field electrophoresis conditions for separating multimegabase-sized DNA was undertaken. Conditions were found for first liberating and then separating DNA up to 6 megabases at higher field strengths and more rapidly than previously reported. In addition, some conditions for transversely pulsed fields produced mobility inversion, in which increased size was accompanied by faster rather than slower migration. Importantly, anomalous migration could be identified by the presence of lateral band spreading, in which the DNA band remained sharply defined but spread laterally while moving down the gel. These results have implications for both practical applications and theoretical models of pulsed-field electrophoresis.