gebhart/patrepeval huggingface dataset:
Abstract 5606: Gallium maltolate inhibits brain tumor volume and blood volume in xenograft model. (2013)

Abstract Purpose: There are limited treatment options for glioblastomas (GBM). Tumor cells have a high requirement for iron; the latter is taken up by cells through transferrin receptor-mediated endocytosis of transferrin-iron. These receptors are highly expressed on GBM cells, which makes them an attractive target for transferrin receptor-directed therapies. Gallium is a group IIIa metal that can function as an iron mimetic by avidly binding to transferrin and incorporating into cells through the transferrin receptor. No studies have been performed to determine the efficacy of gallium-based therapies in brain tumors. Consequently, the goal of this study was to evaluate gallium maltolate in the treatment of a U87 xenograft brain tumor model. Methods: Athymc rats bearing U87 human grade IV astrocytoma cells were studied. Gallium maltolate (50 mg/kg/day, n=5) or saline (n=3) was given intravenously. via an alzet mini pump in the jugular vein. Magnetic resonance imaging (MRI) was performed on days 8 and 18 on a Bruker 9.4 T scanner. Enhancing tumor volumes were determined from the post-contrast T1w images, in all slices showing enhancing tumor. The spin and gradient echo relaxation rate changes were then determined giving estimates of microvascular and total blood volume. ((CBVmicro≈R2=R2MION-R*pre-MION CBVTotal≈ R2* = R2*MION-R2*pre-MION). Results: Gallium maltolate inhibited tumor growth (377132%), as measured by enhancing tumor volume, compared to saline controls (863481%). Treatment shows decrease of CBV micro and CBVTotal compared to the controls. The ratio of R2* /R2, which is a measure of mean vessel diameter, increased in saline treated controls but remained unchanged for the gallium maltolate treated rats. To our knowledge this is the first study performed that uses physiologic MRI measurements to investigate the effects of gallium maltolate on brain tumor xenografts. The differences shown are not statistically significant a result likely due to the small sample sizes, which is being remedied by ongoing additional studies. For the imaging studies included here tissue markers of proliferation (Ki67), hypoxia (HIF1) transferrin receptors, and vascular density (vWF) are being analyzed to provide additional information regarding mechanism of action. In general these results demonstrate, for the first time, that the novel gallium maltolate treatment holds promise for the treatment of malignant brain tumors. Citation Format: Kimberly R. Pechman, Andrew Lozen, Mona Al-Gizawiy, Kathleen Schmainda, Christopher R. Chitambar. Gallium maltolate inhibits brain tumor volume and blood volume in xenograft model. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5606. doi:10.1158/1538-7445.AM2013-5606
Opportunistic Access to PAL Channel for Multi-RAT GAA Transmission in Spectrum Access System (2017)

Spectrum Access System (SAS) is a three tier spectrum sharing framework proposed by the FCC. In this framework the aggregate interference of tier-3 General Authorised Access (GAA) users should be below a predetermined threshold anywhere within the tier-2 Priority Access Licensee (PAL) exclusion zone. GAA are expected to use a diverse range of Radio Access Technologies (RATs) with different levels of loading. We propose an optimal transmit power and probability of spectrum utilisation allocation scheme for GAA users that meets the average aggregate interference constraint within the GAA network. Most of the capacity maximisation studies consider the instantaneous aggregated interference from secondary users. In this paper we present an average aggregated interference method to optimise the capacity of GAA users in a single channel. Simulation results suggest that we can significantly increase the capacity of the channel by considering the probability spectrum utilisation of GAA users.
DCG-FGT transistor: Retention study of Floating Gate charge (2013)

A Dual Control Gate Floating Gate Transistor (DCG-FGT) is a new device used in the circuit design. This component is a floating gate transistor. In this paper, we propose a retention study of floating gate charge. We demonstrate experimentally that the floating charge loss over time is very low.
3-D integration of MQW modulators over active submicron CMOS circuits: 375 Mb/s transimpedance receiver-transmitter circuit (1995)

We accomplish the integration of GaAs-AlGaAs multiple quantum well modulators directly on top of active silicon CMOS circuits. This enables optoelectronic VLSI circuits to be achieved and also allows the design and optimization of the CMOS circuits to proceed independently of the placement and the bonding of surface-normal optical modulators to the circuit. Using this technique, we demonstrate operation of a 0.8 micron CMOS transimpedance receiver-transmitter circuit at 375 Mb/s.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Data from The Ovarian Cancer Chemokine Landscape Is Conducive to Homing of Vaccine-Primed and CD3/CD28–Costimulated T Cells Prepared for Adoptive Therapy (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Chemokines are implicated in T-cell trafficking. We mapped the chemokine landscape in advanced stage ovarian cancer and characterized the expression of cognate receptors in autologous dendritic cell (DC)–vaccine primed T cells in the context of cell-based immunotherapy.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; The expression of all known human chemokines in patients with primary ovarian cancer was analyzed on two independent microarray datasets and validated on tissue microarray. Peripheral blood T cells from five HLA-A2 patients with recurrent ovarian cancer, who previously received autologous tumor DC vaccine, underwent CD3/CD28 costimulation and expansion &lt;i&gt;ex vivo&lt;/i&gt;. Tumor-specific T cells were identified by HER2/neu pentamer staining and were evaluated for the expression and functionality of chemokine receptors important for homing to ovarian cancer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; The chemokine landscape of ovarian cancer is heterogeneous with high expression of known lymphocyte-recruiting chemokines (CCL2, CCL4, and CCL5) in tumors with intraepithelial T cells, whereas CXCL10, CXCL12, and CXCL16 are expressed quasi-universally, including in tumors lacking tumor-infiltrating T cells. DC-vaccine primed T cells were found to express the cognate receptors for the above chemokines. &lt;i&gt;Ex vivo&lt;/i&gt; CD3/CD28 costimulation and expansion of vaccine-primed Tcells upregulated CXCR3 and CXCR4, and enhanced their migration toward universally expressed chemokines in ovarian cancer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; DC-primed tumor-specific T cells are armed with the appropriate receptors to migrate toward universal ovarian cancer chemokines, and these receptors are further upregulated by &lt;i&gt;ex vivo&lt;/i&gt; CD3/CD28 costimulation, which render T cells more fit for migrating toward these chemokines. &lt;i&gt;Clin Cancer Res; 21(12); 2840–50. ©2015 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
NMR System for a Type II Quantum Computer (2007)

Abstract : This project was to use liquid state nuclear magnetic resonance (NMR) as a test-bed to explore the control of information for Type-II quantum computing (QC) and for quantum information processing approaches to quantum simulations. During the first stages of the project we demonstrated NMR based implementations of type-II QC algorithms including the diffusion equation and Burger's equation. These demonstrations relied on a spatial encoding of non-interacting quantum systems. One of the challenges of quantum simulations is the growth of errors during a lattice type calculation. We demonstrated that we could reduce the errors by introducing random operations that commute with the map. This improved the simulation fidelity but important errors still remained. We then attacked these errors directly by exploring both the transients in our implementation (which led to the largest errors) and a series of more robust optimal control pulses. Finally during this last period we focused on quantum simulations of exchange operations over lattices and demonstrated that quantum interference effects involving multiple paths between the exchanging qubits can lead to higher fidelity operations.
Answer Key (2012)

You have accessAdhesion and Adhesives TechnologyJun 2012Answer KeyAlphonsus V. PociusAlphonsus V. Pociushttps://doi.org/10.3139/9783446431775.bmSectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapter FiguresReferencesRelatedDetails 2012Pages: 353-370Print ISBN: 978-3-446-42748-8eISBN: 978-3-446-43177-5 Copyright & Permissions© 2012 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Human vision and electronic imaging III : 26-29 January, 1998, San Jose, California (1998)

Divided into four sections, these symposium papers cover: the keynote address - perspectives in perception and electronic imaging; psychophysical models for electronic imaging; perceptual image quality models; and video image quality.
Unlocking the Hidden Capacity of the Electrical Grid Through Smart Transformer and Smart Transmission (2022)

Power systems are experiencing a rapid and dramatic transformation driven by the massive integration of nondispatchable renewable energy sources, such as wind and solar, and highly variable loads, such as electric vehicles and air conditioning. This challenges existing grid assets, eventually leading to updating them, which, in turn, increases significantly the costs of sustainable technologies. Power electronics is a pivotal technology for electrical power processing for renewable energies and sustainable transportation. By means of “smart” functionalities, power electronics converters already embedded in such applications can also contribute to guaranteeing the overall system’s stable operation. Anyway, this cooperative contribution from distributed devices may be not enough leading to the need for the voltage transformation and power transmission of “system-level” power electronics solutions. In the case of large charging stations, a smart transformer (ST), while, in the case of large solar and wind parks, integration medium- or high-voltage direct current (HVdc) transmissions are system-level solutions. This article wants to review the potential of using such infrastructures to increase the capacity of existing grid assets, avoiding or deferring their upgrade and, hence, reducing the overall costs of renewables integration and the electrification of the transport sector. In fact, the power converters embedded in ST and HVdc can provide fast frequency and voltage response, and precise control of power flow acting at the system level much more effectively and feasibly for system operators as the distributed power converters embedded in several small sources and users. This article reviews, for the first time, these two key power electronics “system-level” solutions together—ST and HVdc—starting from their basic functionalities and showings how they can go beyond them, showing how, with grid-forming functionalities, they can offer new “smart grid” tools to enhance the capability of the existing electric grid infrastructures.
Endoreduplication of nuclear DNA in the developing maize endosperm (1990)

Abstract Multiparametric flow cytometry was used to analyze the development of the endosperm in Zea mays L. during the period from 8 to 20 days after pollination (dap). Nuclear size, DNA content per nucleus, and frequencies of nuclei with varying properties were measured in preparations that included all of the endosperm nuclei of single kernels of the inbred strain Al88. Characteristics of nuclear populations from different kernels on the same ear showed minimal variation. The dynamic changes of non‐mitotic cells involved in endosperm development consisted of alternating periods of DNA replication with non‐replication. Seven rounds of DNA replication had occurred in some nuclei in the later developmental stages with the rate averaging approximately one round per 24‐hour period. Analysis of the DNA levels in the nuclei showed an exact doubling pattern indicating an endoreduplication process, that is, replication of the entire genome during each round. The loosely organized polytenization of the chromatin occurred to varying extents among the nuclei within an endosperm. A weak positive correlation existed between DNA content and size of nuclei suggesting that DNA increases and nuclear growth may not be highly coordinated in this tissue. Increased proportions of the larger nuclei occurred in the later stages of endosperm development. Considering the entire endosperm, the average DNA content per nucleus at the 15‐dap peak level was approximately 12.8 C constituting a 2.7‐fold overall increase from 8 dap.
Isolation and characterization of novel glycolipids with blood group A-related structures: galactosyl-A and sialosylgalactosyl-A. (1987)

Two glycosphingolipids with the following novel structures have been isolated from human blood cells and characterized by NMR, direct probe mass spectrometry, fast atom bombardment-mass spectrometry, and methylation analysis: (Formula: see text). Both structure i and structure ii are characterized by substitution of beta-galactosyl or sialosyl-beta-galactosyl residue at the terminal alpha-GalNAc residue of blood group A determinant and are therefore specific products associated with the blood group A phenotype.
Combination Treatment with Donor-Specific Transfusions and Cyclosporine A Induces Long-Term Survival of Cardiac Allografts in Miniature Swine (2005)

These results are the first to demonstrate the ability of DST to induce operational tolerance to cardiac allografts in large animals, and they suggest that peripheral mechanisms of tolerance mediate this effect.
Octylonium bromide: a smooth muscle relaxant which interferes with calcium ions mobilization. (1983)

A series of "in vitro" experiments have been carried out to determine the mechanisms(s) responsible for the smooth muscle relaxant properties exhibited by octylonium bromide. Unlike N-butyl-scopolammonium bromide, octylonium bromide possesses both competitive and non competitive antimuscarinic and antihistaminic properties. Pretreatment of ileal segments with dibenamie, which destroyed muscarinic spare receptors, revealed the non competitive nature of octylonium bromide antagonism. The competitive antagonism toward BaCl2-induced contraction of rat ileum and aorta suggested that octylonium bromide interferes with Ca++ mobilization. As compared with verapamil a known Ca++ entry blocker and unlike it, octylonium bromide is more effective in antagonizing Ca++-induced contraction in K+ depolarized rat colon than aorta. Both octylonium bromide and verapamil reduced in a concentration-dependent manner the tonic contraction produced by exposure to high K+ of rat duodenum and rabbit ear artery. Both octylonium bromide and verapamil antagonized carbachol-induced phasic plus sustained tonic contraction of rat colon in high K+ Ca++-free medium. Unlike octylonium bromide, verapamil antagonized the phasic contraction only and inhibition of the overall contraction did not exceed 60%. Unlike verapamil, octylonium bromide antagonized norepinephrine-induced contraction of rabbit ear artery in high K+ C++-free medium. Interference with mobilization of cellular and extracellular Ca++ pools produced by different neurohormones is likely to be the mechanism responsible for octylonium bromide smooth muscle relaxant properties in both animals and humans.
Group Delay Dispersion Measurements with Resonance Scanning Interferometry (2013)

We developed a method for group delay and group delay dispersion measurements, based on location of interference resonance peaks. Using simultaneous processing of the data acquired for different spacer distances we achieved high quality results.
An AIB1 Isoform Alters Enhancer Access and Enables Progression of Early-Stage Triple-Negative Breast Cancer (2021)

AIB1Δ4 is an N-terminally truncated isoform of the oncogene amplified in breast cancer 1 (AIB1) with increased expression in high-grade human ductal carcinoma <i>in situ</i> (DCIS). However, the role of AIB1Δ4 in DCIS malignant progression has not been defined. Here we CRISPR-engineered RNA splice junctions to produce normal and early-stage DCIS breast epithelial cells that expressed only AIB1Δ4. These cells showed enhanced motility and invasion in 3D cell culture. In zebrafish, AIB1Δ4-expressing cells enabled invasion of parental cells when present in a mixed population. In mouse xenografts, a subpopulation of AIB1Δ4 cells mixed with parental cells enhanced tumor growth, recurrence, and lung metastasis. AIB1Δ4 chromatin immunoprecipitation sequencing revealed enhanced binding to regions including peroxisome proliferator-activated receptor (PPAR) and glucocorticoid receptor (GR) genomic recognition sites. H3K27ac and H3K4me1 genomic engagement patterns revealed selective activation of breast cancer-specific enhancer sites by AIB1Δ4. AIB1Δ4 cells displayed upregulated inflammatory response genes and downregulated PPAR signaling gene expression patterns. In the presence of AIB1Δ4 enabler cells, parental cells increased NF-κB and WNT signaling. Cellular cross-talk was inhibited by the PPARγ agonist efatutazone but was enhanced by treatment with the GR agonist dexamethasone. In conclusion, expression of the AIB1Δ4-selective cistrome in a small subpopulation of cells triggers an "enabler" phenotype hallmarked by an invasive transcriptional program and collective malignant progression in a heterogeneous tumor population. SIGNIFICANCE: A minor subset of early-stage breast cancer cells expressing AIB1Δ4 enables bulk tumor cells to become invasive, suggesting that selective eradication of this population could impair breast cancer metastasis.
Asymmetric Hydrogenation of Ketones with H2 and Ruthenium Catalysts Containing Chiral Tetradentate S2N2 Ligands (2013)

Getting more for less: In the presence of H2 and a base, air- and moisture-tolerant RuII complexes catalyze the hydrogenation of ketones and aldehydes with excellent activity and chemoselectivity, and with enantioselectivity of up to 95 % under mild conditions. The ratio of substrate to catalyst can be lowered to 106:1. The reactions tolerate scale-up and can be carried out with almost no solvent. A base-free method is available for base-sensitive substrates. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Enhancement of Spatial Sound Quality: A New Reverberation-Extraction Audio Upmixer (2007)

A system for the extraction of uncorrelated reverberation from two-channel (stereo) audio signals is proposed and evaluated. Applications for the new system vary from surround-sound multichannel loudspeaker upmixers for home-theater or automotive audio systems, to headphone-based auralization for enhancing the spatial sound quality of a listening experience. The new system uses the normalized-least-mean-square (NLMS) algorithm to equalize the two input signals with respect to both spectral magnitude and phase before differencing to remove correlated components. A theoretical model of the system based on a stochastic room impulse response model was validated by empirical measurements made in a reverberant hall with a microphone pair, and from a formal subjective evaluation the system is shown to be an effective approach to extracting reverberation from audio recordings.
Block of Purinergic P2X7R Inhibits Tumor Growth in a C6 Glioma Brain Tumor Animal Model (2010)

We examined the expression and pharmacological modulation of the purinergic receptor P2X7R in a C6 glioma model. Intrastriatal injection of C6 cells induced a time-dependent growth of tumor; at 2 weeks postinjection immunohistochemical analysis demonstrated higher levels of P2X7R in glioma-injected versus control vehicle-injected brains. P2X7R immunoreactivity colocalized with tumor cells and microglia, but not endogenous astrocytes. Intravenous administration of the P2X7R antagonist brilliant blue G (BBG) inhibited tumor growth in a spatially dependent manner from the C6 injection site. Treatment with BBG reduced tumor volume by 52% versus that in controls. Double immunostaining indicated that BBG treatment did not alter microgliosis, astrogliosis, or vasculature vessels in C6-injected animals. In vitro, BBG reduced the expression of P2X7R and glioma chemotaxis induced by the P2X7R ligand, 2',3'-O-(4-benzoyl-benzoyl)adenosine triphosphate (BzATP). Immunohistochemical staining of human glioblastoma tissue samples demonstrated greater expression of P2X7R compared to control nontumor samples. These results suggest that the efficacy of BBG in inhibiting tumor growth is primarily mediated by direct actions of the compound on P2X7R in glioma cells and that pharmacological inhibition of this purinergic receptor might serve as a strategy to slow the progression of brain tumors.
Effective Stabilization of Perovskite Cesium Lead Bromide Nanocrystals through Facile Surface Modification by Perfluorocarbon Acid (2020)

CsPbX<sub>3</sub> (X = Cl, Br, I) perovskite nanocrystals (NCs) have attracted much attention as promising materials for next-generation optoelectronic applications. However, improvement of their low stabilities against heating and humidity is needed for practical use. In this work, we focused on perfluorodecanoic acid (PFDA) as a surface ligand and investigated the thermal and chemical stabilities of the photoluminescence (PL) properties of CsPbBr<sub>3</sub> NCs. Oleic acid (OA) adsorbed on the NCs was exchanged for decanoic acid (DA) and PFDA. OA-modified and DA-modified NCs exhibited drastic fluorescence quenching to 12.9 and 21.1% of their initial PL intensities, respectively, after heating at 100 °C for 4 h. In contrast, the PFDA-modified NCs maintained 92.1% of their PL intensity after the same heating. Furthermore, the polar solvent resistance was also improved by PFDA modification. These improvements can be attributed to the strong adsorptivity and high chemical stability of the PFDA ligand.