gebhart/patrepeval huggingface dataset:
Nanoscale coordination polymers exhibiting luminescence properties and NMR relaxivity (2011)

This article presents the first example of ultra-small (3-4 nm) magneto-luminescent cyano-bridged coordination polymer nanoparticles Ln0.33(3+)Gdx3+/[Mo(CN)8]3- (Ln=Eu (x=0.34), Tb (x=0.35)) enwrapped by a natural biocompatible polymer chitosan. The aqueous colloidal solutions of these nanoparticles present a luminescence characteristic of the corresponding lanthanides (5D0→7F0-4 (Eu3+) or the 5D4→7F6-2 (Tb3+)) under UV excitation and a green luminescence of the chitosan shell under excitation in the visible region. Magnetic Resonance Imaging (MRI) efficiency, i.e. the nuclear relaxivity, measurements performed for Ln0.33(3+)Gdx3+/[Mo(CN)8]3- nanoparticles show r1p and r2p relaxivities slightly higher than or comparable to the ones of the commercial paramagnetic compounds Gd-DTPA® or Omniscan® indicating that our samples may potentially be considered as a positive contrast agent for MRI. The in vitro studies performed on these nanoparticles show that they maybe internalized into human cancer and normal cells and well detected by fluorescence at the single cell level. They present high stability even at low pH and lack of cytotoxicity both in human cancer and normal cells.
TBC1D24 genotype–phenotype correlation (2016)

TBC1D24-related epilepsy syndromes show marked phenotypic pleiotropy, with multisystem involvement and severity spectrum ranging from isolated deafness (not studied here), benign myoclonic epilepsy restricted to childhood with complete seizure control and normal intellect, to early-onset epileptic encephalopathy with severe developmental delay and early death. There is no distinct correlation with mutation type or location yet, but patterns are emerging. Given the phenotypic breadth observed, TBC1D24 mutation screening is indicated in a wide variety of epilepsies. A TBC1D24 consortium was formed to develop further research on this gene and its associated phenotypes.
120. THE UNSTABLE PAINFUL SHOULDER (UPS): AS A CAUSE OF PAIN FROM UNRECOGNIZED INSTABILITY IN THE YOUNG ATHLETE (2011)

Purpose: Shoulder pain in the young athlete is often a diagnostic challenge. It is our experience that this pain can be related to a so-called “unstable painful shoulder” (UPS), defined as instability presenting in a purely painful form, without any history of instability but with anatomical (soft tissue or bony) ‘roll-over’ lesions. The objectives are to describe the epidemiology and diagnostic criteria and to report the results of surgical treatment. Method: A prospective review was performed of 20 patients (mean age 22 ± 8 years). Inclusion criteria: a painful shoulder and “roll-over lesions” on imaging or at surgery. Exclusion criteria: a dislocation/subluxation; associated pathology; previous shoulder surgery. Results: Most patients were male (60%), athletes (85%) and involved the dominant arm (80%). All patients denied a feeling of instability and only complained of deep, anterior pain. Most had a history of trauma (80%). All patients had rehabilitation without success and 30% had subacromial injections. All had to stop sports. Most (85%) had anterior or inferior hyperlaxity. All had pain with an anterior apprehension test and relieved by relocation test. ‘Roll-over’ lesions included: labrum detachment (90%), capsular distension (75%), HAGL lesion (10%), glenoid fracture (20%) or Hill-Sachs (40%). Time from symptoms to surgery was 25 ± 23 months. All patients had arthroscopic treatment. Mean follow-up was 38 ± 14 months. Eighteen patients (90%) were very satisfied/satisfied. None had pain at rest, but one (5%) had pain with apprehension test. There was no change in elevation, external or internal rotation (p>0.05). There were no cases of instability. Rowe and Duplay scores improved (p Conclusion: Instability of the shoulder can present in a purely painful form, without any history of dislocations or subluxations. Diagnosis can be difficult, and should be suspected in young patients and athletes. Most patients have deep anterior pain and pain with apprehension test. ‘Roll-over’ lesions are necessary to confirm the diagnosis. Arthroscopic repair is effective.
Audio, visual, and audio-visual egocentric distance perception in virtual environments (2011)

International audience
Hepatocyte growth factor is a novel member of the endothelium-specific growth factors: additive stimulatory effect of hepatocyte growth factor with basic fibroblast growth factor but not with vascular endothelial growth factor (1996)

These results demonstrate that HGF can exert stimulating effects on endothelial cell growth, but not on VSMC growth, in an additive manner with bFGF but not with VEGF. These characteristics of HGF as an endothelium-specific growth factor may provide the opportunity for a new therapeutic strategy for vascular diseases in which the abnormalities were vasoconstriction and pathological growth.
Cellular and wireless LAN transceivers: From systems to circuit design (2011)

RF design has matured to the point where almost any wireless standard (e.g., GSM, WiFi, Bluetooth, etc.) and/or multiple standards operating in different bands can be integrated onto a single chip in deep submicron CMOS. This course is an in-depth tutorial that discusses many of the challenges facing the designer of a single-chip radio, and their solutions. The topics addressed in the course range from the system right down to the circuit level, including: system requirements and the demands they place on transceiver circuit specs, the design of RF front-ends with >;100dB dynamic range at GHz frequencies, direct conversion architectures, autocalibration methods, sub-systems robust to substrate/supply coupling and crosstalk, fast responding PLL synthesizers with low spurious content, and the latest `more digital than analog' developments. This course is aimed at circuit designers who are familiar with the basic terminology of RF and mixed-signal/analog circuits and wish to acquire further depth in RF IC design.
Production of Valuable Lipids from Underutilized Resources and Industrial Wastes by Biorefinery System (2020)

地球環境の保全と資源・エネルギーの再生利用を両立する持続的技術として，海洋大型藻類や火力発電排出ガスを原料としたバイオリファイナリーにより，高度不飽和脂肪酸やカロテノイド，炭化水素などの有用脂質を生産する新規システムの構築を進めている。油糧微生物ラビリンチュラ類オーランチオキトリウム属の有機酸資化性を活用した二段階発酵系とゲノム育種による高機能化を統合して生産性の最大化をめざしているので，その進捗を紹介する。
Detection and quantification of marine larvae orientation in the pelagic environment (2009)

The pelagic larval phase represents a major opportunity for dispersal in benthic organisms, yet behaviors controlling and potentially limiting dispersal are still largely unknown for most larvae. Here, we present a new means of observing the orientation of larvae of all developmental stages in the pelagic environment. A cylindrical frame holding a semi‐open arena in which larvae are filmed is set to drift at a controlled depth within the natural environment. Larval trajectories are extracted from video data and used to quantify orientation behavior. Field tests with late‐stage coral reef fish larvae show that orientation can be detected from individual larval positions in the arena and can be significantly differentiated from random movement or artifactual behavior.
Step-to-Step Ankle Inversion/Eversion Torque Modulation Can Reduce Effort Associated with Balance (2017)

Below-knee amputation is associated with higher energy expenditure during walking, partially due to difficulty maintaining balance. We previously found that once-per-step push-off work control can reduce balance-related effort, both in simulation and in experiments with human participants. Simulations also suggested that changing ankle inversion/eversion torque on each step, in response to changes in body state, could assist with balance. In this study, we investigated the effects of ankle inversion/eversion torque modulation on balance-related effort among amputees (<i>N</i> = 5) using a multi-actuated ankle-foot prosthesis emulator. In stabilizing conditions, changes in ankle inversion/eversion torque were applied so as to counteract deviations in side-to-side center-of-mass acceleration at the moment of intact-limb toe off; higher acceleration toward the prosthetic limb resulted in a corrective ankle inversion torque during the ensuing stance phase. Destabilizing controllers had the opposite effect, and a zero gain controller made no changes to the nominal inversion/eversion torque. To separate the balance-related effects of step-to-step control from the potential effects of changes in average mechanics, average ankle inversion/eversion torque and prosthesis work were held constant across conditions. High-gain stabilizing control lowered metabolic cost by 13% compared to the zero gain controller (<i>p</i> = 0.05). We then investigated individual responses to subject-specific stabilizing controllers following an enforced exploration period. Four of five participants experienced reduced metabolic rate compared to the zero gain controller (-15, -14, -11, -6, and +4%) an average reduction of 9% (<i>p</i> = 0.05). Average prosthesis mechanics were unchanged across all conditions, suggesting that improvements in energy economy might have come from changes in step-to-step corrections related to balance. Step-to-step modulation of inversion/eversion torque could be used in new, active ankle-foot prostheses to reduce walking effort associated with maintaining balance.
<title>Improvements in DCT-based video coding</title> (1997)

We report on recent advances in traditional DCT based video coding at low bitrates. These improvements allow either an increase in coding efficiency or an increase in other functionalities. Our investigation is conducted within the framework of the ongoing work towards the MPEG-4 video standard. The ISO moving picture experts group (MPEG) is currently developing this standard after having completed the MPEG-1 and the MPEG-2 standards. The MPEG-4 video standard is addressing a number of content based as well as traditional functionalities. The development process consists of iterative refinement of the verification model via a set of well defined core experiments. Our first experiment is on improved coding efficiency of intra and uses DC and AC predictions and optimized scanning of DCT coefficients followed by a separate optimized variable length code table. Our second experiment is the study of bidirectional coding to allow additional functionality such as temporal scalability at low bit-rates. We present results of these experiments and summarize our findings.
Mechanisms for hemodynamic instability related to renal replacement therapy: a narrative review (2019)

Hemodynamic instability related to renal replacement therapy (HIRRT) is a frequent complication of all renal replacement therapy (RRT) modalities commonly used in the intensive care unit. HIRRT is associated with increased mortality and may impair kidney recovery. Our current understanding of the physiologic basis for HIRRT comes primarily from studies of end-stage kidney disease patients on maintenance hemodialysis in whom HIRRT is referred to as 'intradialytic hypotension'. Nonetheless, there are many studies that provide additional insights into the underlying mechanisms for HIRRT specifically in critically ill patients. In particular, recent evidence challenges the notion that HIRRT is almost entirely related to excessive ultrafiltration. Although excessive ultrafiltration is a key mechanism, multiple other RRT-related mechanisms may precipitate HIRRT and this could have implications for how HIRRT should be managed (e.g., the appropriate response might not always be to reduce ultrafiltration, particularly in the context of significant fluid overload). This review briefly summarizes the incidence and adverse effects of HIRRT and reviews what is currently known regarding the mechanisms underpinning it. This includes consideration of the evidence that exists for various RRT-related interventions to prevent or limit HIRRT. An enhanced understanding of the mechanisms that underlie HIRRT, beyond just excessive ultrafiltration, may lead to more effective RRT-related interventions to mitigate its occurrence and consequences.
Rabi Lattices (2006)

We present a quantum model of two-level atoms localized in a 3D lattice, based on the Hopfield theory of exciton polaritons. In addition to a polaritonic gap at the exciton energy, a photonic bandgap opens up at the Brillouin zone boundary. Upon tuning the lattice period or angle of incidence to match the photonic gap with the exciton energy, one obtains a combined polaritonic and photonic gap as a generalization of Rabi splitting. For typical experimental parameters, the size of the combined gap is on the order of 25 cm^{-1}, up to 10^5 times the detuned gap size. The dispersion curve contains a branch supporting slow-light modes with vanishing exciton probability density.
ТЕРАПИЯ РАКА ЛЕГКОГО В ПОЖИЛОМ И СТАРЧЕСКОМ ВОЗРАСТЕ И ПРОБЛЕМЫ ЛЕЧЕНИЯ СОПУТСТВУЮЩЕЙ СОМАТИЧЕСКОЙ ПАТОЛОГИИ (2012)

Химиотерапия рака легкого является одним из важнейших компонентов лечения, но возможности ее применения у лиц пожилого и старческого возраста ограничены в связи с ее токсичностью, наличием сопутствующей патологии и общим состоянием пожилых и старых пациентов. В ходе исследования было выявлено, что на конечное решение врача о выборе специального лечения рака легкого у пациентов с наличием феномена полиморбидности влияют такие факторы, как наличие артериальной гипертензии, перенесенный инфаркт миокарда, различные формы ишемической болезни сердца, перенесенное острое нарушение мозгового кровообращения, сахарный диабет 1 и 2 типа, сопутствующая патология почек. На основании проведенного анализа было выявлено, что таргетная терапия немелкоклеточного рака легкого у лиц пожилого и старческого возраста по сравнению со «стандартной» химиотерапией сопровождается меньшей частотой усугубления течения хронической сердечной недостаточности по критерию усугубления функционального класса и случаев клинико-метаболической декомпенсации, нарастания гипергликемии и случаев, потребовавших перехода на инсулинотерапию у лиц с сахарным диабетом 2 типа.
WCDMA Uplink Parallel Interference Cancellation—System Simulations and Prototype Field Trials (2005)

Interference cancellation (IC) is one identified key technology to enhance WCDMA uplink performance. The goal of this contribution is to highlight the relative uplink system capacity improvement available for WCDMA, especially in realistic typical urban radio environments when employing receiver implementations including realistic channel estimation, searcher, and so forth. The performance of the selected limited-complexity parallel IC receiver is first evaluated with link-level simulations in order to provide input to system-level simulations. The system-level methodology is explained and a 40% system-level uplink capacity increase compared to utilizing the conventional RAKE receiver is found. The limited-complexity parallel IC receiver is then evaluated in a single-cell field trial. The trials show that both the mean and the variance of the outer-loop power control is reduced, which implies an overall increased capacity and an increased battery life of the terminals. Furthermore, the observed capacity gains are in accordance with system simulations.
Laser vaporization synthesis of carbon materials in the presence of high-pressure Ar gas (2004)

Laser vaporization of graphite was carried out in the presence of high pressure Ar gas of 0.1-0.8 MPa. We compared the growth processes of three synthesized graphitic carbon particles: single-wall carbon nanohorn, multi-layer graphene, and polyhedral graphite particles. We believe graphitization processes occurred from supersaturated hot carbon vapor, dependent on resident carbon densities and their temperature gradients, lead to the growth of the three graphitic particles.
Gene Control in Germinal Differentiation: Rnf6, a Transcription Regulatory Protein in the Mouse Sertoli Cell (2002)

In mouse Sertoli cells, transcription of the Inha gene encoding the alpha subunit of inhibin, which acts locally as a tumor suppressor, is down-regulated in tumors and in normal cells during aging. Previous studies suggested that regulation of Inha transcription involves the binding of a protein(s) to a repeat of the GGGGC motif in the promoter. Expression screening identified a cDNA encoding a protein that binds this sequence. Of the RING-H2 family, it is the mouse homologue of a human protein of unknown function, RNF6. The mouse gene, Rnf6, is predominantly expressed in two interacting cell types of the testis, Sertoli cells and pachytene spermatocytes. In Sertoli cells, it colocalizes with the PML and Daxx proteins in punctate nuclear bodies. In transient and stable transfectants, Rnf6 expression from a heterologous promoter increased the expression of reporter genes driven by the Inha promoter. In a Sertoli tumor cell line in which expression of both Inha and Rnf6 was reduced, reexpression of the latter restored the level of Inha while, concomitantly, the cells reverted to normal growth control in culture.
Rheological and Mechanical Property Measurements of PMDI Foam at Elevated Temperatures (2014)

A study was undertaken to determine the viscosity of liquefied 20 lb/ft3 poly methylene diisocyanate (PMDI) foam and the stress required to puncture solid PMDI foam at elevated temperatures. For the rheological measurements the foam was a priori liquefied in a pressure vessel such that the volatiles were not lost in the liquefaction process. The viscosity of the liquefied PMDI foam was found to be Newtonian with a power law dependence on temperature log10(μ/Pa s) = 20.6 – 9.5 log10(T/°C) for temperatures below 170 °C. Above 170 °C, the viscosity was in the range of 0.3 Pa s which is close to the lower measurement limit (≈ 0.1 Pa s) of the pressurized rheometer. The mechanical pressure required to break through 20lb/ft3 foam was 500-800 psi at temperatures from room temperature up to 180 °C. The mechanical pressure required to break through 10 lb/ft3 was 170-300 psi at temperatures from room temperature up to 180 °C. We have not been able to cause gas to break through the 20 lb/ft3 PMDI foam at gas pressures up to 100 psi.
Super-finished Surfaces using Meso-micro EDM (2013)

A novel stochastic orbiting strategy combined with extremely low stray capacitance sinking EDM machine offers the capability to achieve super-finished surfaces (Ra <0.1 μm) without pre-polishing of the copper tool electrodes. Surface defects such as inhomogeneity, cracks, arc spots and black spots have been analysed and reduced, while improving material removal rate with lower tool wear. Super-finished surfaces thus generated have uniform white layer (re-solidified layer) with an average thickness below 1 μm. Unlike mirror finishing using EDM with powder mixed dielectric, absence of the additives in dielectric results in smaller gap width during finishing, delivering sub-micron accuracy of the machined features. With the tool electrodes machined using conventional machining techniques such as milling, turning or wire-EDM having surfaces with Ra ≤ 0.2 μm, advamcements of the work offers manufacturing industry an economic and energy efficient super-finishing process, especially in meso-micro scale.
VEGF siRNA Delivery by a Cancer-Specific Cell-Penetrating Peptide (2018)

RNA interference provides an effective tool for developing antitumor therapies. Cell-penetrating peptides (CPPs) are delivery vectors widely used to efficiently transport small-interfering RNA (siRNA) to intracellular targets. In this study, we investigated the efficacy of the cancer-specific CPP carrier BR2 to specifically transport siRNA to cancer-target cells. Our results showed that BR2 formed a complex with anti-vascular endothelial growth factor siRNA (siVEGF) that exhibited the appropriate size and surface charge for in vivo treatment. Additionally, the BR2-VEGF siRNA complex exhibited significant serum stability and high levels of gene-silencing effects in vitro. Moreover, the transfection efficiency of the complex into a cancer cell line was higher than that observed in non-cancer cell lines, resulting in downregulated intracellular VEGF levels in HeLa cells and comprehensively improved antitumor efficacy in the absence of significant toxicity. These results indicated that BR2 has significant potential for the safe, efficient, and specific delivery of siRNA for diverse applications.
ForSense: Accelerating Online Research Through Sensemaking Integration and Machine Research Support (2022)

Online research is a frequent and important activity people perform on the Internet, yet current support for this task is basic, fragmented and not well integrated into web browser experiences. Guided by sensemaking theory, we present ForSense, a browser extension for accelerating people’s online research experience. The two primary sources of novelty of ForSense are the integration of multiple stages of online research and providing machine assistance to the user by leveraging recent advances in neural-driven machine reading. We use ForSense as a design probe to explore (1) the benefits of integrating multiple stages of online research, (2) the opportunities to accelerate online research using current advances in machine reading, (3) the opportunities to support online research tasks in the presence of imprecise machine suggestions, and (4) insights about the behaviors people exhibit when performing online research, the pages they visit, and the artifacts they create. Through our design probe, we observe people performing online research tasks, and see that they benefit from ForSense’s integration and machine support for online research. From the information and insights we collected, we derive and share key recommendations for designing and supporting imprecise machine assistance for research tasks.
The Use of Heptamethine Cyanine Dyes as Drug-Conjugate Systems in the Treatment of Primary and Metastatic Brain Tumors (2021)

Effective cancer therapeutics for brain tumors must be able to cross the blood-brain barrier (BBB) to reach the tumor in adequate quantities and overcome the resistance conferred by the local tumor microenvironment. Clinically approved chemotherapeutic agents have been investigated for brain neoplasms, but despite their effectiveness in peripheral cancers, failed to show therapeutic success in brain tumors. This is largely due to their poor bioavailability and specificity towards brain tumors. A targeted delivery system might improve the efficacy of the candidate compounds by increasing the retention time in the tumor tissue, and minimizing the numerous side effects associated with the non-specific distribution of the chemotherapy agent. Heptamethine cyanine dyes (HMCDs) are a class of near-infrared fluorescence (NIRF) compounds that have recently emerged as promising agents for drug delivery. Initially explored for their use in imaging and monitoring neoplasms, their tumor-targeting properties have recently been investigated for their use as drug carrier systems. This review will explore the recent developments in the tumour-targeting properties of a specific group of NIRF cyanine dyes and the preclinical evidence for their potential as drug-delivery systems in the treatment of primary and metastatic brain tumors.
Adapting a generic match algorithm to align ontologies of human anatomy (2004)

The difficulty inherent in schema matching has led to the development of several generic match algorithms. We describe how we adapted general approaches to the specific task of aligning two ontologies of human anatomy, the Foundational Model of Anatomy and the GALEN Common Reference Model. Our approach consists of three phases: lexical, structural and hierarchical, which leverage different aspects of the ontologies as they are represented in a generic meta-model. Lexical matching identifies concepts with similar names. Structural matching identifies concepts whose neighbors are similar. Finally, hierarchical matching identifies concepts with similar descendants. We conclude by reporting on the lessons we learned.