gebhart/patrepeval huggingface dataset:
Transient concentrations and agonist potency of PGH2 in platelet activation by endogenous arachidonate. (1989)

Human platelets were prelabelled with [14C]arachidonate and stimulated with thrombin or methyl mercury. [14C]PGH2 and the more stable of the other [14C]eicosanoids formed were rapidly extracted with organic solvent cooled to -30 degrees C and analyzed by radio-TLC. TXB2 and PGH2 were also quantified by radioimmunoassay, the latter as its index metabolite PGE2. PGH2 reached its peak concentration of 12 nmol/l after 20-30 s when it amounted to approximately 2/3 of the TXB2 concentration. In the presence of the thromboxane synthase inhibitor dazoxiben, PGH2 peaked after 60 s and afterwards declined in favour of PGE2, PGD2 and PGF2 alpha. Thirty seconds after stimulation with thrombin 1 IU/ml or methyl mercury 20 mumol/l, PGH2 amounted to 35 or 28% of the cyclooxygenase products in the absence and to 66 or 63% in the presence of dazoxiben, respectively. The platelet-activating potency of PGH2 was evaluated with purified PGH2 in platelets pretreated with acetylsalicylic acid. The EC50 values of PGH2 were 0.69 and 19 nmol/l for shape change and aggregation, respectively. U 46619 produced the same effects at 4.1 and 23 nmol/l. PGH2-induced [3H]serotonin release did not exceed 25%, whereas U 46619 was able to induce approximately 50% [3H]serotonin release. Dazoxiben enhanced the aggregation induced by PGH2. Human serum albumin inhibited the aggregating effect of PGH2, suppressed the enhancing effect of dazoxiben and shifted the metabolism of PGH2 to the inhibitory PGD2. The TXA2/PGH2 receptor antagonist daltroban suppressed the agonistic effects of endogenous or added PGH2, demonstrating that the TXA2/PGH2 receptor was its site of action.(ABSTRACT TRUNCATED AT 250 WORDS)
Adsorption and decomposition of dimethyl methylphosphonate on an aluminum oxide surface (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdsorption and decomposition of dimethyl methylphosphonate on an aluminum oxide surfaceM. K. Templeton and W. H. WeinbergCite this: J. Am. Chem. Soc. 1985, 107, 1, 97–108Publication Date (Print):January 1, 1985Publication History Published online1 May 2002Published inissue 1 January 1985https://pubs.acs.org/doi/10.1021/ja00287a018https://doi.org/10.1021/ja00287a018research-articleACS PublicationsRequest reuse permissionsArticle Views966Altmetric-Citations128LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Analysis of channel characteristics and modeling of a transformer for PLC-based loss-of-mains concept (2016)

Loss-of-mains (LoM) protection is crucial in modern smart grids (SGs), where the number of distributed generation (DG) units has increased making the grids more complex. An LoM situation means that the DG unit(s) is/are still supplying the grid while the connection to the supplying electric power distribution grid is off. This can cause fatal injuries to humans and damages to the equipment. A power line communication (PLC) based LoM concept is introduced, where continuous signaling is used as an indication for the LoM protection from the primary substation through the MV grid, the MV/LV transformers, and each low-voltage (LV) grid to the customers. However, the MV/LV transformers constitute a barrier for the PLC. Thus, in this paper, the channel characteristics and modeling of the MV/LV transformer as a function of frequency in the frequency band from 100 Hz to 1 MHz is analyzed. A model for the transformer is compiled and verified by input impedance measurements.
Retardance in three-dimensional polarization ray tracing (2009)

A three-by-three polarization ray tracing matrix P which is defined in global coordinates characterizes the polarization transformations associated with single ray through optical system. The P matrix contains both a geometrical transformation effect and the polarization characteristics of diattenuation and retardance from the optical and polarization elements. In order to separate the geometrical transformation and calculate the "physical" retardance, a non-polarizing ray tracing matrix Q is used. The diattenuation and the retardance of a dove prism are analyzed as an example.
Disease Type- and Status-Specific Alteration of CSF Metabolome Coordinated with Clinical Parameters in Inflammatory Demyelinating Diseases of CNS (2016)

Central nervous system (CNS) inflammatory demyelinating diseases (IDDs) are a group of disorders with different aetiologies, characterized by inflammatory lesions. These disorders include multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and idiopathic transverse myelitis (ITM). Differential diagnosis of the CNS IDDs still remains challenging due to frequent overlap of clinical and radiological manifestation, leading to increased demands for new biomarker discovery. Since cerebrospinal fluid (CSF) metabolites may reflect the status of CNS tissues and provide an interfacial linkage between blood and CNS tissues, we explored multi-component biomarker for different IDDs from CSF samples using gas chromatography mass spectrometry-based metabolite profiling coupled to multiplex bioinformatics approach. We successfully constructed the single model with multiple metabolite variables in coordinated regression with clinical characteristics, expanded disability status scale, oligoclonal bands, and protein levels. The multi-composite biomarker simultaneously discriminated four different immune statuses (a total of 145 samples; 54 MS, 49 NMOSD, 30 ITM, and 12 normal controls). Furthermore, systematic characterization of transitional metabolic modulation identified relapse-associated metabolites and proposed insights into the disease network underlying type-specific metabolic dysfunctionality. The comparative analysis revealed the lipids, 1-monopalmitin and 1-monostearin were common indicative for MS, NMOSD, and ITM whereas fatty acids were specific for the relapse identified in all types of IDDs.
Low noise HTS gradiometers and magnetometers constructed from YBa/sub 2/Cu/sub 3/O/sub 7-x//PrBa/sub 2/Cu/sub 3/O/sub 7-y/ thin films (1995)

D.C. SQUID based gradiometers and magnetometers have been fabricated using thin films of YBa/sub 2/Cu/sub 3/O/sub 7/ and PrBa/sub 2/Cu/sub 3/O/sub 7/ on MgO substrates. Flip-chip magnetometers with 1 cm and 6.25 cm/sup 2/ substrates have been constructed. Our device on the larger substrate with a 430 mm/sup 2/ pickup loop had a sensitivity of (42/spl plusmn/3) fT//spl radic/Hz above 3 Hz and (75/spl plusmn/7) fT//spl radic/Hz at 1 Hz. Numerical simulations of d.c. SQUIDs at 77 K have been conducted over an inductance range from 2 to 1000 pH and a critical current range from 3.2 to 322 /spl mu/A. The results emphasise the need to reduce SQUID inductances in order to obtain lower flux noise. Three layer gradiometric SQUIDs with c-axis microbridge junctions and low inductance have been fabricated. First order gradiometric flux transformers were also made with twin 20 turn spiral SQUID input coils and a pair of larger area balanced sensing coils. These were mounted with the gradiometric SQUIDs in a flip chip configuration to complete the highly symmetrical gradiometers. Measurements at 79 K on one gradiometer gave a gradient sensitivity of (49/spl plusmn/3) pT/m//spl radic/Hz at 300 Hz and (103/spl plusmn/7) pT/m//spl radic/Hz at 1 Hz.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Chemicals On Demand with Phototriggerable Microcapsules (2009)

We report the development of phototriggerable microcapsules and demonstrate the concept of protection and remote release of chemical species. Light-rupturable, liquid-filled microcapsules were prepared by coencapsulation of carbon nanotubes using a simple and robust interfacial polymerization technique. The incorporation of carbon nanotubes endows the microcapsules with the ability to respond to an external optical event. The triggered release of the liquid contents for the microcapsules may be achieved either in air or within a liquid medium via irradiation with a near-IR laser. Rupture of the impermeable shell-wall under irradiation is presumed to be due to an increase in internal pressure due to optothermal heating of the CNTs. The storage and triggered release of reactive small molecules and catalysts was demonstrated in the context of remotely initiated "click" reaction and ring-opening metathesis polymerization.
Ab Initio Materials Science and Engineering using the Molecular Dynamics Method for Total Energy Pseudopotential Calculations (1989)

Abstract A description of the total energy pseudopotential technique and of Car and Parrinello's molecular dynamics method is given. A detailed investigation of the extent to which the electronic degrees of freedom in the molecular dynamics method should be regarded as classical degrees of freedom is presented. It is shown that a cancellation of the errors in the Hellmann-Feynman forces occurs when the molecular dynamics equations of motion are used to evolve the electronic degrees of freedom during a dynamical simulation of the ionic system. Applications of the molecular dynamics method to study surface reconstructions and grain boundaries in germanium and defects in arsenic tri-selenide are briefly described and the possibility of using ab-initio methods to study problems in materials science and engineering is discussed.
Message from the Editor (2016)

The ninth volume of Transactions of The Japan Institute of Electronics Packaging (Trans.JIEP, English version) has been prepared for
ChemInform Abstract: On the Stereoselectivity of the Intramolecular Dioxenone Photocycloaddition. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Computer-augmented environments: das Büro der Zukunft (1995)

Computer-Augmented Environments streben das Ziel an, Computertechnologien mit der physikalischen Welt zu verschmelzen, anstatt eine künstliche Welt (Virtual Reality) durch den Einsatz von Computertechnologie zu erzeugen. Im Mittelpunkt der Betrachtung steht unsere alltaegliche Umgebung, die ihre derzeitige Auspraegung zwar weitestgehend beibehaelt, aber durch neue integrierte Computerfunktionalitaet erweitert oder angereichert. Auf dem Gebiet von Computer-Augmented Environments heben sich besonders die Konzepte von Ubiquitous Computing und Augmented Reality hervor. Obgleich sich ihre grundlegenden Techniken unterscheiden, verfolgen sie eine gemeinsame Philosophie: der Vorrang der physikalischen Welt und die Entwicklung geeigneter Hilfsmittel zur Komfortsteigerung unserer taeglichen Aktivitaeten. Hauptbestandteil der vorliegenden Arbeit ist die Vorstellung einiger Innovationen auf diesem noch relativ jungen Forschungsgebiet, um zu weiteren Entwicklungen in dieser Richtung anzuregen. Die Arbeit führt zu in Kapitel 2 kurz in die Thematik ein und erlaeutert dabei die wichtigsten fachspezifischen Begriffe. Danach werden im Kapitel 3 derzeitige Forschungs- und Entwicklungsprojekte vorgestellt und deren grundlegenden Konzepte beschrieben. Im Kapitel 4 werden die mittels Fragebogen erfassten Anforderungen aus den Anwendungsbereichen Manager, Sekretaerin und Wissenschaftler aufgeführt und einer anschliessenden Bewertung und Stellungnahme unterzogen. Die hieraus gewonnenen Erkenntnisse über die speziellen Anforderungen fliessen zusammen mit den zuvor vorgestellten Anwendungsmoeglichkeiten in die Gestaltung von Anwendungsszenarien ein, die in Kapitel 5 in Form eines Tagesablaufs in erzaehlender Weise dargestellt werden. Hierauf folgt in Kapitel 6 die Erstellung einer Taxonomie, welche die vorgestellten Anwendungsmoeglichkeiten klassifiziert. Abschliessend wird eine Bewertung der behandelten Thematik vorgenommen, die nahtlos in einen Ausblick über zukünftige Entwicklungen in di esem Bereich übergeht.
Navitoclax (ABT-263) Accelerates Apoptosis during Drug-Induced Mitotic Arrest by Antagonizing Bcl-xL (2011)

Combining microtubule-targeting antimitotic drugs with targeted apoptosis potentiators is a promising new chemotherapeutic strategy to treat cancer. In this study, we investigate the cellular mechanism by which navitoclax (previously called ABT-263), a Bcl-2 family inhibitor, potentiates apoptosis triggered by paclitaxel and an inhibitor of kinesin-5 (K5I, also called a KSP inhibitor), across a panel of epithelial cancer lines. By using time-lapse microscopy, we showed that navitoclax has little effect on cell death during interphase, but strongly accelerates apoptosis during mitotic arrest, and greatly increases the fraction of apoptosis-resistant cells that die. By systematically knocking down individual Bcl-2 proteins, we determined that Mcl-1 and Bcl-xL are the primary negative regulators of apoptosis during prolonged mitotic arrest. Mcl-1 levels decrease during mitotic arrest because of an imbalance between synthesis and turnover, and turnover depends in part on the MULE/HUWE1 E3 ligase. The combination of Mcl-1 loss with inhibition of Bcl-xL by navitoclax causes rapid apoptosis in all lines tested. Variation in expression levels of Mcl-1 and Bcl-xL largely determines variation in response to antimitotics alone, and antimitotics combined with navitoclax, across our panel. We concluded that Bcl-xL is a critical target of Bcl-2 family inhibitors for enhancing the lethality of antimitotic drugs in epithelial cancers, and combination treatment with navitoclax and a spindle specific antimitotic, such as a K5I, might be more effective than paclitaxel alone.
ChemInform Abstract: CHEMICAL, KINETIC, AND SPECTROSCOPIC EVIDENCE FOR THE REACTION OF 1‐NAPHTHYLCARBENE WITH ACETONITRILE TO FORM A NITRILE YLIDE (1984)

Abstract 1‐Brom‐naphthalin (I) wird in die Acetylverbindung (II) und weiter in ein Aziren (III) übergeführt.
Re: Lack of Testicular Seipin Causes Teratozoospermia Syndrome in Men (2014)

No AccessJournal of UrologyInvestigative Urology1 Jan 2015Re: Lack of Testicular Seipin Causes Teratozoospermia Syndrome in Men Anthony AtalaMD Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.10.012AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Lack of Testicular Seipin Causes Teratozoospermia Syndrome in Men." The Journal of Urology, 193(1), p. 369 © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 1January 2015Page: 369Supplementary Materials Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Anthony Atala More articles by this author Expand All Advertisement PDF downloadLoading ...
Dual diffusion model of spreading activation for content-based image retrieval (2006)

This paper introduces a content-based information retrieval method inspired by the ideas of spreading activation models. In response to a given query,the proposed approach computes document ranks as their final activation values obtained upon completion of a diffusion process. This diffusion process,in turn,is dual in the sense that it models the spreading of the query 's initial activation simultaneously in two similarity domains: low-level feature-based and high-level semantic.The formulation of the diffusion process relies on an approximation that makes it possible to compute the final activation as a solution to a linear system of differential equations via a matrix exponential without the need to resort to an iterative simulation.The latter calculation is performed efficiently by adapting a sparse routine based on Krylov sub-space projection method.The empirical performance of the described dual diffusion model has been evaluated in terms of precision and recall on the task of content-based digital image retrieval in query-by-example scenario. The obtained experimental results demonstrate that the proposed method achieves better overall performance compared to traditional feature-based approaches. This performance improvement is attained not only when both similarity domains are used, but also when a diffusion model operates only on the feature-based similarities.
Crowned in shamrocks erin't Broad Acres : the emergence of the Irish Catholic community in Yorkshire, and the evolution of the West Riding's forgotten Irish rugby clubs, 1860-c 1920 (2010)

This thesis examines the emergence of the Irish Catholic diaspora in the industrial diocese of the West Riding of Yorkshire, and the evolution of the West Riding's forgotten Irish rugby clubs, 1860-c 1920. In addition to considering the contributions of Irish immigrants in the history of rugby football this thesis explores their religious, nationalist, social and cultural experiences, set within the wider history of Irish immigration in England. The history and establishment of parochial and non-parochial Irish Catholic rugby clubs in the West Riding can be traced back to the 1870s. Diasporic Irish Catholics settled in the county have always been part of rugby football since it's inception, albeit, at a much slower and punctuated rate than that observed among English Protestant communities. The foremost aim of this thesis is to scrutinise the rugby antecedents of Irish Catholics domiciled in the manufacturing centres of the West Riding during the Victorian and early Edwardian periods. In the late nineteenth century, towns and cities across the West Riding had become the great citadels of rugby football. Rugby attracted much participation, giving rise to the Catholic Church establishing its own internalised parochial rugby clubs, which were intended to improve the spiritual and physical well-being of its poor Irish adherents. This thesis, moreover, examines the establishment of non-parochial Irish rugby clubs which acted as sporting auxiliaries to Irish nationalist clubs. Finally, this thesis investigates those opportunities which allowed some working-class Irish Catholics to participate in games of rugby league outside of their own ethno-religious clubs for some of the county's senior professional rugby clubs. Since the main objective of Irish nationalist organisations was to offer financial support and political muscle to the Irish Parliamentary Party, this thesis will argue that the establishment of non-parochial nationalist Irish rugby clubs initially centred on the sport's by products, "gate-money".
Microsecond Consensus for Microsecond Applications (2020)

We consider the problem of making apps fault-tolerant through replication, when apps operate at the microsecond scale, as in finance, embedded computing, and microservices apps. These apps need a replication scheme that also operates at the microsecond scale, otherwise replication becomes a burden. We propose Mu, a system that takes less than 1.3 microseconds to replicate a (small) request in memory, and less than a millisecond to fail-over the system - this cuts the replication and fail-over latencies of the prior systems by at least 61% and 90%. Mu implements bona fide state machine replication/consensus (SMR) with strong consistency for a generic app, but it really shines on microsecond apps, where even the smallest overhead is significant. To provide this performance, Mu introduces a new SMR protocol that carefully leverages RDMA. Roughly, in Mu a leader replicates a request by simply writing it directly to the log of other replicas using RDMA, without any additional communication. Doing so, however, introduces the challenge of handling concurrent leaders, changing leaders, garbage collecting the logs, and more - challenges that we address in this paper through a judicious combination of RDMA permissions and distributed algorithmic design. We implemented Mu and used it to replicate several systems: a financial exchange app called Liquibook, Redis, Memcached, and HERD. Our evaluation shows that Mu incurs a small replication latency, in some cases being the only viable replication system that incurs an acceptable overhead.
Supplementary Figure S1 from H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma (2023)

&lt;p&gt;H3B-6527 effects in a HCC cell line Hep3B orthotopic xenografts in female nude mice.&lt;/p&gt;
Don't settle for less than the best: use optimization to make decisions (2007)

Many systems design, configuration, runtime and management decisions must be made from a large set of possible alternatives. Ad hoc heuristics have traditionally been used to make these decisions, but they provide no guarantees of solution quality. We argue that operations research-style optimization techniques should be used to solve these problems. We provide an overview of these techniques and where they are most effective, address common myths and fears about their use in making systems decisions, give several success stories and propose systems areas that could benefit from their application. 1
Policy Statement (1998)

In the twenty-one years since its founding, the International Journal of Urban and Regional Research (IJURR) has become a well-established, successful journal with a record of having published pioneering work in the field.We, the new editors and the new editorial board, wish to express our most heartfelt appreciation for the work of our predecessors: first