gebhart/patrepeval huggingface dataset:
Generic Vehicle Architecture for the integration and sharing of in-vehicle and extra-vehicle sensors (2010)

In this paper we present a Generic Vehicle Architecture (GVA), developed as part of the UK MOD GVA programme that addresses the issues of dynamic platform re-role through modular capability integration and behaviour orchestration. The proposed architecture addresses the need for: a) easy integration with legacy and future systems, and architectures; b) scalability from individual sensors, individual human users, vehicles and patrols to battle groups and brigades; c) rapid introduction of new capabilities in response to a changing operational scenario; d) be agnostic of communications systems, devices, operating systems and computer platforms. The GVA leverages the use of research output and tools developed by the International Technology Alliance (ITA) in Network and Information Science<sup>1</sup> programme, in particular the ITA Sensor Fabric<sup>2-4</sup> developed to address the challenges in the areas of sensor identification, classification, interoperability and sensor data sharing, dissemination and consumability, commonly present in tactical ISR/ISTAR,<sup>5</sup> and the Gaian Dynamic Distributed Federated Database (DDFD)<sup>6-8</sup> developed the challenges of accessing distributed sources of data in an ad-hoc environment where the consumers do not have the knowledge of the location of the data within the network. The GVA also promotes the use of off-the-shelf hardware, and software which is advantageous from the aspect of easy of upgrading, lower cost of support and replacement, and speed of re-deploying platforms through a "fitted for but not with" approach. The GVA exploits the services orientated architecture (SOA) environment provided by the ITA Sensor Fabric to enhance the capability of legacy solutions and applications by enabling information exchange between them by, for example, providing direct near real-time communication between legacy systems. The GVA, a prototype implementation demonstrator of this architecture has demonstrated its utility to fusing, exploiting and sharing situational awareness information for force protection, and platform and device health and usage information for logistics and deployment management.
Requirements for the Development of Bacillus Anthracis Spore Reference Materials Used to Test Detection Systems (2006)

Bacillus anthracis spores have been used as biological weapons and the possibility of their further use requires surveillance systems that can accurately and reliably detect their presence in the environment. These systems must collect samples from a variety of matrices, process the samples, and detect the spores. The processing of the sample may include removal of inhibitors, concentration of the target, and extraction of the target in a form suitable for detection. Suitable reference materials will allow the testing of each of these steps to determine the sensitivity and specificity of the detection systems. The development of uniform and well-characterized reference materials will allow the comparison of different devices and technologies as well as assure the continued performance of detection systems. This paper discusses the special requirements of reference materials for Bacillus anthracis spores that could be used for testing detection systems. The detection of Bacillus anthracis spores is based on recognition of specific characteristics (markers) on either the spore surface or in the nucleic acids (DNA). We have reviewed the specific markers and their relevance to characterization of reference materials. We have also included the approach for the characterization of candidate reference materials that we are developing at the NIST laboratories. Additional applications of spore reference materials would include testing sporicidal treatments, techniques for sampling the environment, and remediation of spore-contaminated environments.
Electrical and Optical Modeling of 4H-SiC Avalanche Photodiodes (2008)

Optimal physical models and material parameters for 4H-SiC avalanche photodiodes (APDs) were studied using a two-dimensional device simulation tool. In the models, we took account of temperature-dependent impact ionization and absorption coefficient as a function of wavelength. The absorption coefficient spectra derived in this work exhibited a rapid increase below ∼300 nm, which can be qualitatively incorporated into indirect and direct band transition models. The simulated characteristics were in good agreement with the measured characteristics.
Estimation of the Arrhenius parameters for silane .dblarw. silylene + hydrogen and .DELTA.Hfo(SiH2) by a nonlinear regression analysis of the forward and reverse reaction rate data (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEstimation of the Arrhenius parameters for silane .dblarw. silylene + hydrogen and .DELTA.Hfo(SiH2) by a nonlinear regression analysis of the forward and reverse reaction rate dataHarry K. Moffat, Klavs F. Jensen, and Robert W. CarrCite this: J. Phys. Chem. 1991, 95, 1, 145–154Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/j100154a031https://doi.org/10.1021/j100154a031research-articleACS PublicationsRequest reuse permissionsArticle Views162Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Octyl Gallate Markedly Promotes Anti-Amyloidogenic Processing of APP through Estrogen Receptor-Mediated ADAM10 Activation (2013)

Our previous studies showed that the green tea-derived polyphenolic compound (-)-epigallocatechin-3 gallate (EGCG) reduces amyloid-β (Aβ) production in both neuronal and mouse Alzheimer's disease (AD) models in concert with activation of estrogen receptor-α/phosphatidylinositide 3-kinase/protein kinase B (ERα/PI3K/Akt) signaling and anti-amyloidogenic amyloid precursor protein (APP) α-secretase (a disintegrin and metallopeptidase domain-10, ADAM10) processing. Since the gallate moiety in EGCG may correspond to the 7α position of estrogen, thereby facilitating ER binding, we extensively screened the effect of other gallate containing phenolic compounds on APP anti-amyloidogenic processing. Octyl gallate (OG; 10 µM), drastically decreased Aβ generation, in concert with increased APP α-proteolysis, in murine neuron-like cells transfected with human wild-type APP or "Swedish" mutant APP. OG markedly increased production of the neuroprotective amino-terminal APP cleavage product, soluble APP-α (sAPPα). In accord with our previous study, these cleavage events were associated with increased ADAM10 maturation and reduced by blockade of ERα/PI3k/Akt signaling. To validate these findings in vivo, we treated Aβ-overproducing Tg2576 mice with OG daily for one week by intracerebroventricular injection and found decreased Aβ levels associated with increased sAPPα. These data indicate that OG increases anti-amyloidogenic APP α-secretase processing by activation of ERα/PI3k/Akt signaling and ADAM10, suggesting that this compound may be an effective treatment for AD.
Differentiation of the Infarct Core from Ischemic Penumbra within the First 4.5 Hours, Using Diffusion Tensor Imaging-Derived Metrics: A Rat Model (2017)

Objective: To investigate whether the diffusion tensor imaging-derived metrics are capable of differentiating the ischemic penumbra (IP) from the infarct core (IC), and determining stroke onset within the first 4.5 hours. Materials and Methods: All procedures were approved by the local animal care committee. Eight of the eleven rats having permanent middle cerebral artery occlusion were included for analyses. Using a 7 tesla magnetic resonance system, the relative cerebral blood flow and apparent diffusion coefficient maps were generated to define IP and IC, half hour after surgery and then every hour, up to 6.5 hours. Relative fractional anisotropy, pure anisotropy (rq) and diffusion magnitude (rL) maps were obtained. One-way analysis of variance, receiver operating characteristic curve and nonlinear regression analyses were performed. Results: The evolutions of tensor metrics were different in ischemic regions (IC and IP) and topographic subtypes (cortical, subcortical gray matter, and white matter). The rL had a significant drop of 40% at 0.5 hour, and remained stagnant up to 6.5 hours. Significant differences (p < 0.05) in rL values were found between IP, IC, and normal tissue for all topographic subtypes. Optimal rL threshold in discriminating IP from IC was about -29%. The evolution of rq showed an exponential decrease in cortical IC, from -26.9% to -47.6%; an rq reduction smaller than 44.6% can be used to predict an acute stroke onset in less than 4.5 hours. Conclusion: Diffusion tensor metrics may potentially help discriminate IP from IC and determine the acute stroke age within the therapeutic time window.
New High- and Low-Temperature Phase Changes of ZIF-7: Elucidation and Prediction of the Thermodynamics of Transitions (2015)

We have found that the 3D zeolitic imidazolate framework ZIF-7 exhibits far more complex behavior in response to the adsorption of guest molecules and changes in temperature than previously thought. We believe that this arises from the existence of different polymorphs and different types of adsorption sites. We report that ZIF-7 undergoes a displacive, nondestructive phase change upon heating to above ∼700 °C in vacuum, or to ∼500 °C in CO2 or N2. This is the first example of a temperature-driven phase change in 3D ZIF frameworks. We predicted the occurrence of the high-temperature transition on the basis of thermodynamic arguments and analyses of the solid free-energy differences obtained from CO2 and n-butane adsorption isotherms. In addition, we found that ZIF-7 exhibits complex behavior in response to the adsorption of CO2 manifesting in double transitions on adsorption isotherms and a doubling of the adsorption capacity. We report adsorption microcalorimetry, molecular simulations, and detailed XRD investigations of the changes in the crystal structure of ZIF-7. Our results highlight mechanistic details of the phase transitions in ZIF-7 that are driven by adsorption of guest molecules at low temperature and by entropic effects at high temperature. We derived a phase diagram of CO2 in ZIF-7, which exhibits surprisingly complex re-entrant behavior and agrees with our CO2 adsorption measurements over a wide range of temperatures and pressures. We predicted phase diagrams of CH4, C3H6, and C4H10. Finally, we modeled the temperature-induced transition in ZIF-7 using molecular dynamics simulations in the isobaric-isothermal ensemble, confirming our thermodynamic arguments.
Heterologous transposon tagging of the DRL1 locus in Arabidopsis. (1993)

The development of heterologous transposon tagging systems has been an important objective for many laboratories. Here, we demonstrate the use of a Dissociation (Ds) derivative of the maize transposable element Activator (Ac) to tag the DRL1 locus of Arabidopsis. The drl1 mutant shows highly abnormal development with stunted roots, few root hairs, lanceolate leaves, and a highly enlarged, disorganized shoot apex that does not produce an inflorescence. The mutation was shown to be tightly linked to a transposed Ds, and somatic instability was observed in the presence of the transposase source. Some plants showing somatic reversion flowered and produced large numbers of wild-type progeny. These revertant progeny always inherited a DRL1 allele from which Ds had excised. Analysis of the changes in DNA sequence induced by the insertion and excision of the Ds element showed that they were typical of those induced by Ac and Ds in maize.
Ultrathin Nanosheets of Li2MSiO4 (M = Fe, Mn) as High-Capacity Li-Ion Battery Electrode (2012)

Novel ultrathin Li(2)MnSiO(4) nanosheets have been prepared in a rapid one pot supercritical fluid synthesis method. Nanosheets structured cathode material exhibits a discharge capacity of ~340 mAh/g at 45 ± 5 °C. This result shows two lithium extraction/insertion performances with good cycle ability without any structural instability up to 20 cycles. The two-dimensional nanosheets structure enables us to overcome structural instability problem in the lithium metal silicate based cathode materials and allows successful insertion/extraction of two complete lithium ions.
The expression of high molecular weight kininogen on human umbilical vein endothelial cells. (1988)

High molecular weight kininogen (HMWK) functions as a cofactor for activation of plasma serine zymogens and as an inhibitor of tissue cysteine proteases. Cell surfaces to which HMWK binds may provide sites for regulation of these systems. Localization of these HMWK-dependent processes at sites of vascular injury may depend on its binding to specific receptors on endothelial cells. In culture, passaged human umbilical vein endothelial cells (HUVEC) bind anti-HMWK antibody to the cell surface and contain 171 +/- 75 ng of HMWK/10(8) cells. [35S]Methionine-labeled HUVEC in culture synthesize a 120-kDa protein immunoisolated using an anti-kininogen antibody, and a 3500-nucleotide message for human HMWK was detected by Northern blot in RNA extracted from HUVEC. HUVEC also express unoccupied binding sites for HMWK on their surface. 125I-HMWK specifically binds to HUVEC in a reaction requiring Zn2+. 125I-HMWK binding to HUVEC is saturable at 4 degrees C but not at 23 degrees C. 125I-HMWK binds to HUVEC with equal affinity as unlabeled HMWK. Kallikrein, factor XII, fibrinogen, fibronectin, and thrombin do not inhibit 125I-HMWK binding to HUVEC. 125I-HMWK-HUVEC binding remains fully reversible at 60 min following the addition of a 50-fold molar excess HMWK. HUVEC express 9.3 +/- 2.0 X 10(5) (mean +/- S.E.) HMWK binding sites/cell (Kd = 52 +/- 13 nM). Both added and cell-bound 125I-HMWK migrate at 120 kDa on sodium dodecyl sulfate gel electrophoresis, suggesting that the protein remains uncleaved upon binding to the HUVEC surface. These studies indicate that HUVEC synthesize HMWK and the HUVEC surface has a site for its expression. By synthesizing and localizing HMWK to the cell surface, endothelial cells may contribute to the activation of plasma's contact serine zymogens and regulation of tissue cysteine proteases.
PTK 7 Is a Transforming Gene and Prognostic Marker for Breast Cancer and Nodal Metastasis Involvement (2014)

Protein Tyrosin Kinase 7 (PTK7) is upregulated in several human cancers; however, its clinical implication in breast cancer (BC) and lymph node (LN) is still unclear. In order to investigate the function of PTK7 in mediating BC cell motility and invasivity, PTK7 expression in BC cell lines was determined. PTK7 signaling in highly invasive breast cancer cells was inhibited by a dominant-negative PTK7 mutant, an antibody against the extracellular domain of PTK7, and siRNA knockdown of PTK7. This resulted in decreased motility and invasivity of BC cells. We further examined PTK7 expression in BC and LN tissue of 128 BC patients by RT-PCR and its correlation with BC related genes like HER2, HER3, PAI1, MMP1, K19, and CD44. Expression profiling in BC cell lines and primary tumors showed association of PTK7 with ER/PR/HER2-negative (TNBC-triple negative BC) cancer. Oncomine data analysis confirmed this observation and classified PTK7 in a cluster with genes associated with agressive behavior of primary BC. Furthermore PTK7 expression was significantly different with respect to tumor size (ANOVA, p = 0.033) in BC and nodal involvement (ANOVA, p = 0.007) in LN. PTK7 expression in metastatic LN was related to shorter DFS (Cox Regression, p = 0.041). Our observations confirmed the transforming potential of PTK7, as well as its involvement in motility and invasivity of BC cells. PTK7 is highly expressed in TNBC cell lines. It represents a novel prognostic marker for BC patients and has potential therapeutic significance.
Molecular Characterization of Subtype H11N9 Avian Influenza Virus Isolated from Shorebirds in Brazil (2015)

Migratory aquatic birds play an important role in the maintenance and spread of avian influenza viruses (AIV). Many species of aquatic migratory birds tend to use similar migration routes, also known as flyways, which serve as important circuits for the dissemination of AIV. In recent years there has been extensive surveillance of the virus in aquatic birds in the Northern Hemisphere; however in contrast only a few studies have been attempted to detect AIV in wild birds in South America. There are major flyways connecting South America to Central and North America, whereas avian migration routes between South America and the remaining continents are uncommon. As a result, it has been hypothesized that South American AIV strains would be most closely related to the strains from North America than to those from other regions in the world. We characterized the full genome of three AIV subtype H11N9 isolates obtained from ruddy turnstones (Arenaria interpres) on the Amazon coast of Brazil. For all gene segments, all three strains consistently clustered together within evolutionary lineages of AIV that had been previously described from aquatic birds in North America. In particular, the H11N9 isolates were remarkably closely related to AIV strains from shorebirds sampled at the Delaware Bay region, on the Northeastern coast of the USA, more than 5000 km away from where the isolates were retrieved. Additionally, there was also evidence of genetic similarity to AIV strains from ducks and teals from interior USA and Canada. These findings corroborate that migratory flyways of aquatic birds play an important role in determining the genetic structure of AIV in the Western hemisphere, with a strong epidemiological connectivity between North and South America.
CT-Compatible Medical Drilling Stylet (2012)

This paper describes the design of a compact, lightweight CT-compatible, drill-press that is designed to be used in either a hand-held or stand-alone mode to assist with percutaneous bone based interventions. Previous medical drilling tools that have been developed have a metal structure and typically have one actuator for advancing the drill (feed) and another for rotating it (speed). After defining the device functional requirements and specifications, a deterministic design process was followed to generate several design concepts that were then evaluated based on their ability to satisfy the functional requirements. A final concept that uses a custom screw-spline to achieve helical motion of a shaft that is attached to a standard orthopedic drill was selected for prototyping. The design uses a single actuator to drive both the screw and spline nuts through two different gear ratios, resulting in a fixed ratio between the feed and speed. Apart from the motor which is placed away from the central drill axis, the device is largely made from plastic materials. A custom experimental setup was developed that enabled drilling into bone inside a CT scanner to be examined. Results showed that the device was successfully able to penetrate thick cortical bone and that its structure did not appreciably distort the medical images. Keywords: medical robotics, computed tomography, X-ray, drill, interventional radiology, bone
ANGIOGRAPHIC FINDINGS IN NORMAL AND DISEASED GALLBLADDERS INCLUDING ISCHAEMIC CHOLECYSTITIS AND INFARCTION OF THE GALLBLADDER (1982)

Angiographic studies were performed on 60 normal and diseased gallbladders obtained from cholecystectomy specimens and necropsy examinations. The normal macro and microangiographic pattern was confirmed, as was the reduction in the number of blood vessels in chronic cholecystitis and cholelithiasis. Histological correlation however showed that the degree of arteriographic change paralleled the degree of histological disease. The microvascular pattern was directly related to the degree of mucosal villous atrophy, a change which may be important in the pathogenesis of some types of gallbladder disease. The most severe angiographic changes occurred in the case of ischaemic cholecystitis, and contrasted with the normal blood vessel pattern in a case of thin walled infarction of the gallbladder.
Defect Control in Zinc Oxynitride Semiconductor for High-Performance and High-Stability Thin-Film Transistors (2013)

The fabrication of thin-film transistor devices incorporating active semiconductors based on zinc oxynitride (ZnON) compound is presented. It is demonstrated that the addition of appropriate dopant, gallium, in ZnON, suppresses the formation of shallow donor, nitrogen vacancies, and significantly improves electrical characteristics of the resulting TFT. The Ga:ZnON devices with field-effect mobility values exceeding 50 cm 2 /Vs are achieved, which makes them suitable as switching or driving elements in next-generation flat-panel displays.
Eröffnungsverfahren (2004)

Die Entwicklung heuristischer Lösungsverfahren für das P | sij | Cmax-Problem sowie die Analyse ihrer Eigenschaften stehen im Mittelpunkt der Arbeit. In diesem Kapitel werden alle in die Untersuchung einbezogenen Eröffnungsverfahren dargestellt und eingeordnet, wobei sowohl auf die existierenden als auch alle neu entwickelten Lösungsansätze eingegangen wird. Dabei sind von den über 100 im folgenden vorgestellten Verfahrensvarianten, die sich auf sechs Basisverfahren zurückfuhren lassen, erst fünf auf zwei Grundstrategien basierende Eröffnungsverfahren in der Literatur beschrieben worden.1, 2 Die neu entwickelten Verfahrensansätze ergeben sich in erster Linie durch Übertragung von Lösungsideen für verwandte Problemstellungen, wobei i. d. R. lediglich geringfügige Modifikationen bzw. Erweiterungen erforderlich sind. Aufgrund der reihenfolgeabhängigen Rüstzeiten in Verbindung mit dem parallelen Maschinensystem lassen sich oftmals zusätzliche Variationen innerhalb der Verfahrensklassen entwickeln. Eine Übertragung weiterer Lösungsansätze ist dagegen häufig wegen der unterschiedlichen Zielsetzungen der anderen Problemstellungen schwierig.3