gebhart/patrepeval huggingface dataset:
Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block (2005)

Congenital heart block develops in fetuses after placental transfer of Ro/SSA autoantibodies from rheumatic mothers. The condition is often fatal and the majority of live-born children require a pacemaker at an early age. The specific antibody that induces the heart block and the mechanism by which it mediates the pathogenic effect have not been elucidated. In this study, we define the cellular mechanism leading to the disease and show that maternal autoantibodies directed to a specific epitope within the leucine zipper amino acid sequence 200-239 (p200) of the Ro52 protein correlate with prolongation of fetal atrioventricular (AV) time and heart block. This finding was further confirmed experimentally in that pups born to rats immunized with p200 peptide developed AV block. p200-specific autoantibodies cloned from patients bound cultured cardiomyocytes and severely affected Ca2+ oscillations, leading to accumulating levels and overload of intracellular Ca2+ levels with subsequent loss of contractility and ultimately apoptosis. These findings suggest that passive transfer of maternal p200 autoantibodies causes congenital heart block by dysregulating Ca2+ homeostasis and inducing death in affected cells.
Explosive Pancake Bouncing on Hot Superhydrophilic Surfaces (2021)

The rapid detachment of liquid droplets from engineered surfaces in the form of complete rebound, pancake bouncing, or trampolining has been extensively studied over the past decade and is of practical importance in many industrial processes such as self-cleaning, anti-icing, energy conversion, and so on. The spontaneous trampolining of droplets needs an additional low-pressure environment and the manifestation of pancake bouncing on superhydrophobic surfaces requires meticulous control of macrotextures and impacting velocity. In this work, we report that the rapid pancake-like levitation of impinging droplets can be achieved on superhydrophilic surfaces through the application of heating. In particular, we discovered explosive pancake bouncing on hot superhydrophilic surfaces made of hierarchically non-interconnected honeycombs, which is in striking contrast to the partial levitation of droplets on the surface consisting of interconnected microposts. This enhanced droplet bouncing phenomenon, characterized by a significant reduction in contact time and increase in the bouncing height, is ascribed to the production and spatial confinement of pressurized vapor in non-interconnected structures. The manifestation of pancake bouncing on the superhydrophilic surface rendered by a bottom-to-up boiling process may find promising applications such as the removal of trapped solid particles.
The crystal and molecular structure of 2',3',5'-tri-O-acetyl-6-O-(mesitylenesulphonyl)guanosine (1978)

The structure of a 6-O-mesitylenesulphonyl derivative of 2',3',5'-tri-O-acetylguanosine, C 24 H 29 N50 10 S, has&#13;\nbeen determined by X-ray diffraction. Crystals are monoclinic, a = 26.370 (4), b = 8.200 (2), c =&#13;\n17.991 (3) A, fl = 132.77 (4) o. The solution of the structure in space group C2 was not straightforward and is&#13;\ndescribed in detail. Refinement converged at R = 0.110 for 1102 observed reflections. The guanine base&#13;\ndisplays some deviations from its usual geometry due to the loss of C(6)-O(6) double-bond character. The&#13;\nribose sugar is C(2')-endo puckered.
The effect of the adaptive devices parameters on driving (2018)

The development of a new technologies has led to a differentiation between design requirements and human physical abilities. In difficult conditions, human performance decreases and the probability of accidents and injuries increases. As a consequence, part of the driver attention is directed to overcoming unnecessary difficulties. Human-vehicle-environment system must meet certain ergonomic conditions to be able to operate effectively. The article discusses issues related to the using in vehicles selected adaptations to the needs of drivers with disabilities. Therefore, an additional element in the form of specialized adaptation is added to the above system. Attention was also drawn to the lack of legal regulations regarding proper location considering various types of motoric dysfunctions. The next step of the presented considerations is the research review regarding the impact of adaptive devices on driving and road safety. In the literature on the subject there are many questions related to ergonomics: whether such devices, their functionality or its lack can have a significant impact on convenience and thus for safety while driving. Problems arising while driving a car have been identified. The authors sought parameters which determine the discomfort of the driver that appears when using the adaptation. The considerations included in the article can be used to determine the assumptions of device design, assembly and proper use.
2.2 V Operation power heterojunction FETfor personal digital cellular telephones (1995)

The authors describe the 950 MHz power performance of a 2.2 V operation double-doped AlGaAs/lnGaAs/AlGaAs heterojunction FET(HJFET) for personal digital cellular telephones. The fabricated HJFET exhibited 600 mA/mm maximum drain current, 260 mS/mm transconductance and 9.4 V gate-to-drain breakdown voltage. A 21 mm gate-periphery device operating with a drain bias of 2.2 V, demonstrated 1.86 W (32.7 dBm) output power and 62.8% power-added efficiency with –50.5 dBc adjacent channel leakage power at 50 kHz off-centre frequency.
Use of Model Predictive Control in isolated Microgrid with a hybrid Batteries -Hydrogen Storage (2019)

International audience
Increased ion conductance across mammalian membranes modified with conjugated oligoelectrolytes (2013)

Variation in conjugated oligoelectrolyte (COE) repeat units is shown to affect the rate of COE insertion into mammalian membrane patches and membrane patch stabilities. These findings suggest that it is possible to find COE structures that do not destroy membranes while at the same time allow for more facile transmembrane movement of ions/substrates.
Early photosensitizer uptake kinetics predict optimum drug-light interval for photodynamic therapy (2015)

Photodynamic therapy (PDT) has shown promising results in targeted treatment of cancerous cells by developing localized toxicity with the help of light induced generation of reactive molecular species. The efficiency of this therapy depends on the product of the intensity of light dose and the concentration of photosensitizer (PS) in the region of interest (ROI). On account of this, the dynamic and variable nature of PS delivery and retention depends on many physiological factors that are known to be heterogeneous within and amongst tumors (e.g., blood flow, blood volume, vascular permeability, and lymph drainage rate). This presents a major challenge with respect to how the optimal time and interval of light delivery is chosen, which ideally would be when the concentration of PS molecule is at its maximum in the ROI. In this paper, a predictive algorithm is developed that takes into consideration the variability and dynamic nature of PS distribution in the body on a region-by-region basis and provides an estimate of the optimum time when the PS concentration will be maximum in the ROI. The advantage of the algorithm lies in the fact that it predicts the time in advance as it takes only a sample of initial data points (~12 min) as input. The optimum time calculated using the algorithm estimated a maximum dose that was only 0.58 &plusmn; 1.92% under the true maximum dose compared to a mean dose error of 39.85 &plusmn; 6.45% if a 1 h optimal light deliver time was assumed for patients with different efflux rate constants of the PS, assuming they have the same plasma function. Therefore, if the uptake values of PS for the blood and the ROI is known for only first 12 minutes, the entire curve along with the optimum time of light radiation can be predicted with the help of this algorithm.
xPF: packet filtering for low-cost network monitoring (2003)

The ever-increasing complexity in network infrastructures is making critical the demand for network monitoring tools. While the majority of network operators rely on low-cost open-source tools based on commodity hardware and operating systems, the increasing link speeds and complexity of network monitoring applications have revealed inefficiencies in the existing software organization, which may prohibit the use of such tools in high-speed networks. Although several new architectures have been proposed to address these problems, they require significant effort in re-engineering the existing body of applications. We present an alternative approach that addresses the primary sources of inefficiency without significantly altering the software structure. Specifically, we enhance the computational model of the Berkeley packet filter (BPF) to move much of the processing associated with monitoring into the kernel, thereby removing the overhead associated with context switching between kernel and applications. The resulting packet filter, called xPF, allows new tools to be more efficiently implemented and existing tools to be easily optimized for high-speed networks. We present the design and implementation of xPF as well as several example applications that demonstrate the efficiency of our approach.
Testing surfactants as additives for clay improvement: compaction and suction effects (2016)

This paper presents an exploratory study on surfactants as additives to improve soil properties. It is hypothesized that surfactant molecules populate the air-water interfaces reducing surface tension and suction thus allowing a control of the mechanical response of the soil. Suction measurements by means of a high suction tensiometer, compaction tests and Atterberg limits were conducted in mixtures of sand and kaolin, with and without a surfactant solution. The results revealed a prominent effect on suction, but to a lesser extent on the Atterberg limits and compaction behavior (the maximum dry density). This targeted effect of the surfactants suggests its molecules populate, not only the air-water interfaces decreasing surface tension, but may be adsorbing to the clay particles and forming micelles in the pore water as well. Therefore the interplay between the three may influence the soil behavior.
Abstract 1292: Pharmacokinetics of CPX-351: A nano-scale liposomal fixed molar ratio of cytarabine-daunorubicin (Cyt:Daun) in patients with advanced leukemia (2011)

Abstract Background: CPX-351 is a liposomal formulation that co-encapsulates Cyt and Daun enabling delivery of both drugs at a synergistic 5:1 molar ratio. A Phase I study in advanced AML patients demonstrated substantial efficacy with complete remissions (CRs) and acceptable safety. The MTD was 101 units/m2. One unit of CPX-351 contains 1 mg Cyt and 0.44mg of Daun. Here we examine the PK of CPX-351 as a function of dose, inter-patient variability and patient characteristics in order to identify potential PD relationships. Methods: 35 male and female patients with advanced hematologic malignancies were included in the PK portion of this Phase I trial and received 24, 32, 43, 57, 76, 101, or 134 units/m2 of CPX-351 by IV infusion over 90 minutes on Days 1, 3, and 5. Validated LC/MS/MS assays were used for determination of total plasma Cyt and Daun. PK parameters [Cmax, AUC, t1/2, Vss, CL, Cmax/Dose, AUC/Dose] were determined on Days 1 and 5. Results: Mean Cyt and Daun PK parameters are presented in the table below. No significant differences were observed in t1/2, Vss, CL, Cmax/Dose, or AUC/Dose among dose groups on either study day, although some drug accumulation was observed from day 1 to day 5. Cyt and Daun PK parameters were not correlated with patient gender, age or race. Incidence of non-hematologic toxicity increased with dose and systemic exposure. CRs were observed in patients receiving doses of 32-134 units/m2 of CPX-351. The responses at 101 units/m2 and above appear to be more durable. The Cyt:Daun molar ratio remained near 5:1 for up to 48 hours on both study days for all dose levels. Conclusions: Cyt and Daun delivered in CPX-351 exhibited linear single dose and multiple dose PK and low inter-patient variability in plasma concentrations within dose groups. CPX-351 provides predictable, extended systemic exposure of elevated Cyt:Daun concentrations near a 5:1 molar ratio. The 100 unit/m2 dose is undergoing testing in Phase II studies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1292. doi:10.1158/1538-7445.AM2011-1292
Free-space optical communication systems (FOCUS): a U.S. Army overview (2002)

The Army's objective is to design, develop and demonstrate its 'ability to distribute information around the battlefield.' Future Army systems will be based on a survivable, adaptable network capable of integrating commercial services and securely utilizing bandwidth for voice, data, and video applications. However, microwave bandwidth allocation has been a serious problem (given crosstalk, interference and frequency management) for a mobile, adaptive communication network. Because of the inherent advantages of the high data rate, crosstalk independence, jam - resistance, covertness and quick system setup time, the Army is looking into optical wireless communication as a means to address this communications requirement. However, development of a fielded laser communication system requires the development of enabling technologies, the understanding of physical limits and performance, and concept of operations (CONOPS).
Change of Mechanical Properties of High Strength Line Pipe by Thermal Coating Treatment (2005)

In strain-based design, the overmatch condition in the girth weld portion primarily must be maintained. The pipes may also be required to have a low yield to tensile (Y/T) ratio and a high uniform elongation (U.EL) in the longitudinal direction to achieve a high compressive buckling strain. However, change in the mechanical properties by heating during coating treatment has not been paid attention so much. Furthermore, how much the mechanical properties change is affected by production conditions is unclear. This study aims to clarify firstly the relation between the mechanical properties (Y/T ratio, U.EL etc.) and the microstructure and secondly the change in mechanical properties by thermal coating treatment. The Y/T ratio and U.EL are affected by the volume fraction of ferrite and the secondary phase, which are changed by thermomechanical control processing (TMCP) conditions. For example, use of dual phase microstructure is very effective for decreasing the Y/T ratio and increasing the U.EL as the pipe. On the other hand, yield strength (YS) rises and the U.EL does not change after coating. The increase in the YS after coating is influenced by the microstructure and TMCP conditions. Resultantly, dependence of the Y/T ratio on the microstructure and TMCP conditions is reduced for line pipes after thermal coating treatment.
A Full-Duplex Radio-over-Fiber Transport System (2008)

A full-duplex radio-over-fiber transport system based on two modes injection-locked Fabry-Perot laser diode is proposed and demonstrated. Good performance of BER was obtained over 40 km SMF transmission in our proposed systems.
高速光通信中的集成纳米硅波导与设备 (2010)

With progress in fabrication technology, integrated photonics plays an increasingly important role in highspeed optical communications, from monolithic transmitters and receivers for advanced optical modulation formats to on-chip subsystems for optical signal processing. We review our recent work on the highly tailorable physical properties of silicon waveguides for communication and signal processing applications, using slot structures. Controllable chromatic dispersion, nonlinearity, and polarization properties of the waveguides are presented, and the enabled wideband wavelength conversion, optical tunable delay, and signal processing of polarization-multiplexing data channels are discussed.
Bile acids: a potential role in the pathogenesis of pharyngeal malignancy (2016)

This is the first demonstration that bile acids induce TGF-β1 and MMP-9 in pharyngeal cells. TGF-β1 is considered a master switch for EMT, while MMP-9 is a part of the EMT proteome which degrades basement membranes. This implies a potential role for bile acids in pharyngeal carcinogenesis through the mechanism of EMT and suggests potential novel therapeutic targets.
Editorial. Special issue on Integral Biomathics: The Necessary Conjunction of the Western and Eastern Thought Traditions for Exploring the Nature of Mind and Life. (2017)

The idea about this special issue came from a paper published as an updated and upridged version of an older memorial lecture given by Brian D. Josephson and Michael Conrad at the Gujarat Vidyapith University in Ahmedabad, India on March 2, 1984. The title of this paper was “Uniting Eastern Philosophy and Western Science” (1992). We thought that this topic deserves to be revisited after 25 years to demonstrate to the scientific community which new insights and achievements were attained in this fairly broad field during this period.
Azimuth Angle Resolution Improvement Technique with Neural Network (2020)

This paper introduces a method to improve the azimuth angle resolution using MIMO-FMCW radar. When using a MIMO-FMCW radar, a 2D radar image composed of a range axis and an azimuth axis can be obtained. The range resolution is determined by the bandwidth, and the azimuth resolution is determined by the length of the virtual antenna array and the number of virtual antenna elements. To improve the azimuth angle resolution while avoiding aliasing, in this paper, the virtual antenna was placed wider with non-uniform spacing. Then, deep learning technique was applied to reduce the side lobe effect. The proposed method was verified through experiments using simulation signals and emulation signals based on measurements.
Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the Staphylococcus aureus FabI Enzyme–Product Complex (2013)

Drug-target kinetics has recently emerged as an especially important facet of the drug discovery process. In particular, prolonged drug-target residence times may confer enhanced efficacy and selectivity in the open in vivo system. However, the lack of accurate kinetic and structural data for a series of congeneric compounds hinders the rational design of inhibitors with decreased off-rates. Therefore, we chose the Staphylococcus aureus enoyl-ACP reductase (saFabI)--an important target for the development of new anti-staphylococcal drugs--as a model system to rationalize and optimize the drug-target residence time on a structural basis. Using our new, efficient, and widely applicable mechanistically informed kinetic approach, we obtained a full characterization of saFabI inhibition by a series of 20 diphenyl ethers complemented by a collection of 9 saFabI-inhibitor crystal structures. We identified a strong correlation between the affinities of the investigated saFabI diphenyl ether inhibitors and their corresponding residence times, which can be rationalized on a structural basis. Because of its favorable interactions with the enzyme, the residence time of our most potent compound exceeds 10 h. In addition, we found that affinity and residence time in this system can be significantly enhanced by modifications predictable by a careful consideration of catalysis. Our study provides a blueprint for investigating and prolonging drug-target kinetics and may aid in the rational design of long-residence-time inhibitors targeting the essential saFabI enzyme.
Transflective IPS‐LCD with improved reflective contrast ratio (2009)

Abstract— In order to improve the reflective contrast ratio of transflective IPS‐LCDs, a novel pixel design for a normally white reflective IPS has been proposed. In this design, the large‐inter‐electrode‐spacing layout using a novel driving method and a double‐layered electrode have effectively reduced the light leakage. By applying these two technologies, a transflective IPS‐LCD has been successfully demonstrated with a high contrast ratio (15:1) in the reflective mode and a wide‐viewing‐angle characteristic in the transmissive mode.
Lack of Chemokine Signaling through CXCR5 Causes Increased Mortality, Ventricular Dilatation and Deranged Matrix during Cardiac Pressure Overload (2011)

Lack of CXCR5 leads to LV dilatation and increased mortality during pressure overload, possibly via lack of an increase in SLRPs. This study demonstrates a critical role of the chemokine CXCL13 and CXCR5 in survival and maintaining of cardiac structure upon pressure overload, by regulating proteoglycans essential for correct collagen assembly.
A scalable and adaptive web client-server architecture (2000)

The World Wide Web has become the most popular way of exchanging various kinds of data and performing applications such as electronic commerce. Unfortunately, the increasing demand for Web service cannot be satisfied by the increase in the network and computer capacities. Therefore, there exists an immediate need for software solutions to improve the Web service. This thesis describes a new Web client-server architecture that aims at minimizing the average response time observed by the Web users. The proposed architecture applies an adaptive replication algorithm that brings the Web resources as close as possible to the users who access those resources frequently. It also provides mechanisms for load balancing and increasing the reliability of Web service. The servers are responsible for replication of Web resources, and informing the clients about the locations of replicas. The clients are capable of selecting the best replica location to satisfy a particular request. 
We have implemented a prototype of the proposed client-server architecture, called Web++. Web++ clients and servers can run on top of the existing Web servers and browsers, and enhance their capabilities without requiring any modifications to the existing Web infrastructure. Web++ clients can be downloaded and executed on Web browsers transparently. 
The smart clients of Web++ are capable of performing other tasks in addition to selecting the best server from which they could request a particular resource. One such task is batch transmission of Web resources which means submitting a requested resource together with all of its embedded resources in one response. Batch resources transmission reduces the response time by minimizing the number of request and response rounds between a client and a server. 
It is possible to improve the Web service performance further by using clusters (groups) of relevant resources as the unit of replication. We propose a distributed clustering algorithm that identifies relevant resources from user request patterns. The communication overhead can be reduced by using clusters as the replication unit since a client can request multiple resources from the same server through the same connection.