gebhart/patrepeval huggingface dataset:
Revenue metering in the presence of distortion and unbalance: myths and reality (2002)

This paper considers some indices, both those usually measured and others recently proposed, to characterize the energy consumption and to support a tariffing strategy in the presence of harmonic distortion and unbalance. It also discusses the expected uncertainty in their measurement. The main conclusion is that a single index cannot characterize the supply and loading quality; several indices and quantities must be considered in order to identify the utility's and the customers' contributions to harmonic pollution.
A comparative analysis of structural parameters obtained by diffractometer and scanning-densitometer measurements (1976)

The structure of cytosine monohydrate has been redetermined with reflexion data obtained from
automatic digital scanning of Weissenberg films. The previous determination with diffractometer data
[McClure & Craven, Acta Cryst. (1973), B29, 1234--1238] converged to an R of 0.037, with
average estimated standard deviations of 0002 A and 015 ° in derived bond lengths and angles. The
photographic data set converged to an R of 0-0672 with e.s.d.'s of 0-004--0-005 A and 0.3-0.4 °. Normal
probability plots showed that the positional (and the derived geometric) parameters were very comparable;
the vibrational parameters were rather less so, some systematic error being apparent. The overall
conclusion from the study is that the two data sets have given essentially the same positional description
of the structure.
Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures (2022)

Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools for dentistry. Here, different scaffolds were tested for use during the pulp revascularization process, including poly(vinyl alcohol)-PVA hydrogels or resins, collagen hydrogels and poly(vinyl alcohol) PVA/Chitosan (PVA/CS) nanofibers. Based on time to degradation (21 days), nanofibers were chosen to be incorporated with ciprofloxacin and IDR-1002 (each at 50 mg/g). Nanofibers containing ciprofloxacin and IDR-1002 had anti-biofilm activity against <i>Enterococcus faecalis, Staphylococcus aureus</i> and a multispecies oral biofilm, besides anti-inflammatory activities. The <i>in vivo</i> subcutaneous tissue response to tooth fragments filled with nanofibers demonstrated a pulp-like tissue formation, when compared to empty teeth fragments. Thus, we designed a strong antimicrobial, immunomodulatory and regenerative candidate for pulp revascularization and regeneration procedures.
Gas chromatography/mass spectrometric and nuclear magnetic resonance spectrometric studies of carcinogenic polynuclear aromatic hydrocarbons in tobacco and marijuana smoke condensates (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGas chromatography/mass spectrometric and nuclear magnetic resonance spectrometric studies of carcinogenic polynuclear aromatic hydrocarbons in tobacco and marijuana smoke condensatesM. L. Lee, Milos. Novotny, and K. D. BartleCite this: Anal. Chem. 1976, 48, 2, 405–416Publication Date (Print):February 1, 1976Publication History Published online1 May 2002Published inissue 1 February 1976https://pubs.acs.org/doi/10.1021/ac60366a048https://doi.org/10.1021/ac60366a048research-articleACS PublicationsRequest reuse permissionsArticle Views1069Altmetric-Citations154LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Regional Sensitivity of Chondrocyte Gene Expression to Coactive Mechanical Load and Exogenous TNF-α Stimuli (2014)

Both mechanical load and elevated levels of proinflammatory cytokines have been associated with the risk for developing osteoarthritis (OA), yet the potential interaction of these mechanical and biological factors is not well understood. The purpose of this study was to evaluate the response of chondrocytes to the effects of dynamic unconfined compression, TNF-α, and the simultaneous effects of dynamic unconfined compression and TNF-α. The response to these three treatments was markedly different and, taken together, the response in the gene expression of chondrocytes to the different treatment conditions suggest a complex interaction between structure, biology, and mechanical loading.
Squaramides: physical properties, synthesis and applications (2011)

Squaramides are remarkable four-membered ring systems derived from squaric acid that are able to form up to four hydrogen bonds. A high affinity for hydrogen bonding is driven through a concomitant increase in aromaticity of the ring. This hydrogen bonding and aromatic switching, in combination with structural rigidity, have been exploited in many of the applications of squaramides. Substituted squaramides can be accessed via modular synthesis under relatively mild or aqueous conditions, making them ideal units for bioconjugation and supramolecular chemistry. In this tutorial review the fundamental electronic and structural properties of squaramides are explored to rationalise the geometry, conformation, reactivity and biological activity.
Practical enzymic syntheses of ribulose 1,5 bisphosphate and ribose 5-phosphate (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPractical enzymic syntheses of ribulose 1,5 bisphosphate and ribose 5-phosphateChi-Huey Wong, Stephen D. McCurry, and George M. WhitesidesCite this: J. Am. Chem. Soc. 1980, 102, 27, 7938–7939Publication Date (Print):December 1, 1980Publication History Published online1 May 2002Published inissue 1 December 1980https://pubs.acs.org/doi/10.1021/ja00547a023https://doi.org/10.1021/ja00547a023research-articleACS PublicationsRequest reuse permissionsArticle Views310Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Methods, Figures 1 - 9 from Tivantinib (ARQ 197) Exhibits Antitumor Activity by Directly Interacting with Tubulin and Overcomes ABC Transporter–Mediated Drug Resistance (2023)

&lt;p&gt;Supplementary method and Figures. Figure S1 contains expression levels of c-MET in the cells used in this paper. Figure S2 contains the photographs taken after treatment with microtubule inhibitor. Figure S3 contains Immunohistochemistry of tubulin after tivantinib treatment. Figure S4 contains the photographs indicated the effect of tivantinib on tubulin. Figure S5 contains immunoblot data of various cells treated with various microtubule inhibitors. Figure S6 contains mouse body weight change and immunoblot data of xenografts. Figure S7 contains the data of tubulin competition assay using various inhibitors. Figure S8 contains the result of docking simulation using GOLD docking program. Figure S9 contains the data of apoptotic cell after drug treatment.&lt;/p&gt;
Respiratory tract infections in Greenland: results of an audit project (2004)

The study showed that it is possible to carry out an APO audit in Greenland, and that there was a moderate difference in the diagnosis and treatment between Greenland and Denmark. An increased use of paraclinical tests may result in quality improvement.
User Behaviour Analytics (2019)

This report displays user behavior data from a credentials entry web page.
Confirmed identies of proteins from a two-dimensional map of Syrian hamster embryo cells (1999)

The Syrian hamster embryo (SHE) cell transformation assay is widely used to screen chemicals for carcinogenic potential. However, the biochemical mechanisms of transformation in SHE cells are incompletely understood relative to other rodent systems. Thus identification of proteins which change during transformation can provide clues to biochemical mechanisms. Previously, we published a map of SHE cell proteins based on comparisons to other maps. In this report we provide direct sequence analysis of numerous proteins which were previously identified solely by electrophoretic mobility. Protein sequencing verified original spot identifications and extended the range of identified proteins. The updated map will assist in evaluating biochemical mechanisms of morphological transformation in hamster cells.
Mass Transport through Nanostructured Membranes: Towards a Predictive Tool (2016)

This study proposes a new mechanism to understand the transport of solvents through nanostructured membranes from a fundamental point of view. The findings are used to develop readily applicable mathematical models to predict solvent fluxes and solute rejections through solvent resistant membranes used for nanofiltration. The new model was developed based on a pore-flow type of transport. New parameters found to be of fundamental importance were introduced to the equation, i.e., the affinity of the solute and the solvent for the membrane expressed as the hydrogen-bonding contribution of the solubility parameter for the solute, solvent and membrane. A graphical map was constructed to predict the solute rejection based on the hydrogen-bonding contribution of the solubility parameter. The model was evaluated with performance data from the literature. Both the solvent flux and the solute rejection calculated with the new approach were similar to values reported in the literature.
An Animal Model for the Study of Lung Protective Therapies During One Lung Ventilation (OLV) in Children (2008)

One-lung ventilation (OLV) is the intentional collapse of one lung during surgical procedures in the chest. The objective of this report is to demonstrate that a piglet model of pediatric OLV mimics the clinical sequelae, and thus is valid to study lung protective interventions. Pediatric pigs (n = 7; 21 ± 1 d old; 7.7 ± 0.5 kg) were instrumented and exposed to OLV (left lung collapsed) for 3 hrs, followed by 30 min of bilateral lung ventilation (BLV) before sacrifice and tissue harvest. Pulmonary compliance (Cp) and resistance (Rp) were measured half-hourly and plasma samples were drawn hourly for inflammatory cytokine analysis. Cp dropped to 86% and Rp rose to 148% of baseline with OLV, which is consistent with clinical observations given the anatomical differences of the pig thorax. Plasma levels of TNF-α and IL- 6 rose throughout the protocol, consistent with clinical observations. Lung histology showed greater atelectasis in the collapsed lungs following 30 min of BLV. The piglet model is valid for the study of OLV-induced lung injury and may be useful for the study of potential therapies to improve outcomes in the pediatric population.
Leadership and decision making (2018)

Whether leading a small team or a multinational corporation, within the public or private sector, a thorough understanding of the theory and best practice of leadership is essential. Leadership: Regional and Global Perspectives provides a fresh approach to leading in contemporary business environments. The theory component is complemented by a focus on strategic application. Each chapter features case studies highlighting the practical application of key concepts by organisational leaders in the Australasian region. Case studies at the end of each chapter provide a more nuanced analysis of the theory, while accompanying questions encourage students to think critically. Learning is further supported through the inclusion of learning objectives, key terms, further readings and review questions. An extensive bank of web resources is available to lecturers to support their teaching. Written by an expert team of academics from across Australia, Leadership gives students the tools they need to navigate their leadership journey.
Supplementary Table 3 from Suppression of MicroRNA-9 by Mutant EGFR Signaling Upregulates FOXP1 to Enhance Glioblastoma Tumorigenicity (2023)

&lt;p&gt;PDF file - 85KB, The intersection of CLIP-seq data with miR-9 target sites predicted by TargetScan and PicTar yielded a list of putative miR-9 targets.&lt;/p&gt;
Exploring Cognitive Benefits as an Alternative Motivation for Engaging Older Adults in Crowdwork (2015)

Older adults are not frequent crowd workers on general purpose crowd work platforms. Prior work suggests they are not motivated to complete crowd work with existing motivational frameworks. As an alternative, we explore the cognitive benefits of online work as a potential way of engaging older adults in crowdwork. As a first step, we present survey results from experts in aging and cognitive training to assess whether common crowd work tasks might offer cognitive benefits as currently structured.so
Evolutionary Algorithm Optimized Centralized Offline Localization and Mapping (2018)

Effective exploration of hardly accessible unknown environments impacts many applications such as monitoring underground infrastructure, exploration of natural resources, e.g. oil and gas, and in-vivo exploration for diagnostic purposes. In many of these scenarios, the environment is only accessible by miniaturized agents (mm-sized or less). Consequently, miniature autonomous sensory agents (MASA) can play an imperative role. However, MASA present wide range of challenges caused by their scaled-down size. Firstly, these agents are strongly limited in energy, consequently, special design constraints must be set. Secondly, these agents are usually kinetically passive thus, the widely used Simultaneous Localization and Mapping (SLAM) techniques can not be used. As a result, a new problem definition is needed, where agents' motion is not controlled and, consequently, localization and mapping is conducted offline. In this paper, we formally introduce what we dub as the Centralized Offline Localization And Mapping (COLAM) problem, highlighting its objectives and constraints. Furthermore, we illustrate a comprehensive solution to this problem using a non-dominated sorting genetic algorithm (NSGA) based framework to optimize the agents' resources and conduct adequate localization and mapping. Finally, we apply this solution on two different environments each with different physical properties.
Table S1 from An Anti–CLL-1 Antibody–Drug Conjugate for the Treatment of Acute Myeloid Leukemia (2023)

&lt;p&gt;hydroxyl radical footprinting of hu6E7.N54A&lt;/p&gt;
Small-Molecule Antibiotics Inhibiting tRNA-Regulated Gene Expression Is a Viable Strategy for Targeting Gram-Positive Bacteria (2020)

Bacterial infections and the rise of antibiotic resistance, especially multidrug resistance, have generated a clear need for discovery of novel therapeutics. We demonstrated that a small-molecule drug, PKZ18, targets the T-box mechanism and inhibits bacterial growth. The T-box is a structurally conserved riboswitch-like gene regulator in the 5' untranslated region (UTR) of numerous essential genes of Gram-positive bacteria. T-boxes are stabilized by cognate, unacylated tRNA ligands, allowing the formation of an antiterminator hairpin in the mRNA that enables transcription of the gene. In the absence of an unacylated cognate tRNA, transcription is halted due to the formation of a thermodynamically more stable terminator hairpin. PKZ18 targets the site of the codon-anticodon interaction of the conserved stem I and reduces T-box-controlled gene expression. Here, we show that novel analogs of PKZ18 have improved MICs, bactericidal effects against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA), and increased efficacy in nutrient-limiting conditions. The analogs have reduced cytotoxicity against eukaryotic cells compared to PKZ18. The PKZ18 analogs acted synergistically with aminoglycosides to significantly enhance the efficacy of the analogs and aminoglycosides, further increasing their therapeutic windows. RNA sequencing showed that the analog PKZ18-22 affects expression of 8 of 12 T-box controlled genes in a statistically significant manner, but not other 5'-UTR regulated genes in MRSA. Very low levels of resistance further support the existence of multiple T-box targets for PKZ18 analogs in the cell. Together, the multiple targets, low resistance, and synergy make PKZ18 analogs promising drugs for development and future clinical applications.
Microstructure of Friction-Stir-Welded High-Nitrogen Stainless Steel (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Synthesis of a Potent and Selective18F-Labeled δ-Opioid Receptor Antagonist Derived from the Dmt-Tic Pharmacophore for Positron Emission Tomography Imaging (2008)

Identification and pharmacological characterization of two new selective delta-opioid receptor antagonists, derived from the Dmt-Tic pharmacophore, of potential utility in positron emission tomography (PET) imaging are described. On the basis of its high delta selectivity, H-Dmt-Tic--Lys(Z)-OH (reference compound 1) is a useful starting point for the synthesis of (18)F-labeled compounds prepared by the coupling of N-succinimidyl 4-[ (18)F]fluorobenzoate ([(18)F]SFB) with Boc-Dmt-Tic--Lys(Z)-OH under slightly basic conditions at 37 degrees C for 15 min, deprotection with TFA, and HPLC purification. The total synthesis time was 120 min, and the decay-corrected radiochemical yield of [(18)F]- 1 was about 25-30% ( n = 5) starting from [(18)F]SFB ( n = 5) with an effective specific activity about 46 GBq/micromol. In vitro autoradiography studies showed prominent uptake of [ (18)F]- 1 in the striatum and cortex with significant blocking by 1 and UFP-501 (selective delta-opioid receptor antagonist), suggesting high specific binding of [(18)F]- 1 to delta-opioid receptors. Noninvasive microPET imaging studies revealed the absence of [(18)F]- 1 in rat brain, since it fails to cross the blood-brain barrier. This study demonstrates the suitability of [ (18)F]- 1 for imaging peripheral delta-opioid receptors.
Pain Intensity Estimation from Mobile Video Using 2D and 3D Facial Keypoints (2020)

Managing post-surgical pain is critical for successful surgical outcomes. One of the challenges of pain management is accurately assessing the pain level of patients. Self-reported numeric pain ratings are limited because they are subjective, can be affected by mood, and can influence the patient's perception of pain when making comparisons. In this paper, we introduce an approach that analyzes 2D and 3D facial keypoints of post-surgical patients to estimate their pain intensity level. Our approach leverages the previously unexplored capabilities of a smartphone to capture a dense 3D representation of a person's face as input for pain intensity level estimation. Our contributions are adata collection study with post-surgical patients to collect ground-truth labeled sequences of 2D and 3D facial keypoints for developing a pain estimation algorithm, a pain estimation model that uses multiple instance learning to overcome inherent limitations in facial keypoint sequences, and the preliminary results of the pain estimation model using 2D and 3D features with comparisons of alternate approaches.
Discrimination of Sleep Spindles in Ear-EEG (2019)

Sleep spindles are brief oscillatory events observed in EEG measurements during sleep, related to both sleep staging and basic neuroscience. The objective of this study was to investigate to which extent sleep spindles are observable from ear-EEG. The analysis was based on single-night recordings from 12 subjects, wearing both a polysomnography setup and two light-weight mobile EEG devices (ear-EEG). By introducing a sleep spindle index capable of discriminating between epochs with distinct spindles and distinctly spindle-free epochs, we describe to which extent the most clear cut sleep spindles (as labeled using scalp EEG) can be detected using ear-EEG. We find that ear-EEG can be used to detect sleep spindles, at a performance level similar to scalp derivations. We speculate that part of the observed discrepancy between ear-EEG and the gold standard (scalp EEG) could be caused by the visibility of different spindles in the ear-EEG.
Nanoparticle Optics:  The Importance of Radiative Dipole Coupling in Two-Dimensional Nanoparticle Arrays (2003)

In this paper, the electromagnetic interactions between noble metal nanoparticles are studied by measuring the extinction spectra of two-dimensional arrays of Au and Ag cylinders and trigonal prisms that have been fabricated with electron beam lithography. The nanoparticles are typically 200 nm in diameter and 35 nm in height; both hexagonal and square array patterns have been considered with lattice spacings that vary from 230 to 500 nm. The extinction spectra typically have a maximum in the 700−800 nm region of the spectrum, and this maximum blue shifts as lattice spacing is reduced, having typically a 40 nm decrease in λmax for a 100 nm decrease in lattice spacing. The results are similar for the different noble metals, array patterns, and nanoparticle shapes. The extinction spectra have been modeled using coupled dipole calculations, and the observed spectral variations are in good qualitative agreement with experimental data. Moreover, the computational analysis indicates that the blue shifts are due to radiative dipolar coupling between the nanoparticles and retardation effects. These effects result in a net depolarization of the dipole couplings for lattice spacings of 200−500 nm.