gebhart/patrepeval huggingface dataset:
VEGFR3gene structure, regulatory region, and sequence polymorphisms (2001)

Vascular endothelial growth factor receptor 3 (VEGFR-3) is required for cardiovascular development during embryogenesis. In adults, this receptor is expressed in lymphatic endothelial cells, and mutant VEGFR3 alleles have been implicated in human hereditary lymphedema. To better understand the basis of its specific endothelial lineage-restricted expression, we have characterized the VEGFR3 gene and its regulatory 5' flanking region. The human gene contains 31 exons, of which exons 30a and 30b are alternatively spliced. The VEGFR3 proximal promoter is TATA-less and contains stretches of sequences homologous with the mouse Vegfr3 promoter region. In transfection experiments of cultured cells, the Vegfr3 promoter was shown to control endothelial cell-specific transcription of downstream reporter genes. This result was further confirmed in vivo; in a subset of transgenic mouse embryos, a 1.6 kb Vegfr3 promoter fragment directed weak lymphatic endothelial expression of the LacZ marker gene. This suggests that endothelial cell-specific elements occur in the proximal promoter, although further enhancer elements are probably located elsewhere. The sequence, organization, and variation in the VEGFR3 gene and its regulatory region provide important tools for the molecular genetic analysis of the lymphatic system and its disorders.
Supplementary Figure 5 from Lin<sup>−</sup>Sca-1<sup>+</sup>CD49f<sup>high</sup> Stem/Progenitors Are Tumor-Initiating Cells in the <i>Pten</i>-Null Prostate Cancer Model (2023)

Supplementary Figure 5 from Lin&lt;sup&gt;−&lt;/sup&gt;Sca-1&lt;sup&gt;+&lt;/sup&gt;CD49f&lt;sup&gt;high&lt;/sup&gt; Stem/Progenitors Are Tumor-Initiating Cells in the &lt;i&gt;Pten&lt;/i&gt;-Null Prostate Cancer Model
Epithelial Electrophysiology: Ion Transport by Epithelia . Papers from a symposium. Stanley G. Schultz, Ed. Raven, New York, 1981. xviii, 270 pp., illus. $32. Society of General Physiologists Series, vol. 36. (1982)

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1D profiling using highly dispersive guided waves (2015)

Corrosion is one of the industries major issues regarding the integrity of assets. Currently inspections are conducted at regular intervals to ensure a sufficient integrity level of these assets. Cost reduction while maintaining a high level of reliability and safety of installations is a major challenge. There are many situations where the actual defect location is not accessible, e.g., a pipe support or a partially buried pipe. Guided wave tomography has been developed to reconstruct the wall thickness. In case of bottom of the line corrosion, i.e., a single corrosion pit, a simpler approach may be followed. Data is collected in a pit-catch configuration at the 12 o'clock position using highly dispersive guided waves. The phase spectrum is used to invert for a wall thickness profile in the circumferential direction, assuming a Gaussian defect profile. An EMAT sensor design has been made to measure at the 12 o'clock position of a pipe. The concept is evaluated on measured data, showing good sizing capabilities on a variety simple defect profiles.
Simulated Scale-up and Cost Estimate of a Process for Alkaline Isomerization of Lactose to Lactulose Using Boric Acid as Complexation Agent (1997)

A continuous pilot plant process for converting lactose to lactulose, using boric acid as a complexation agent was previously developed. To appraise the commercial feasibility of the process, a scale-up to a commercial plant using the ERRC Food Process Simulator, a process simulator developed at the Eastern Regional Research Center was projected and a cost estimate made. The cost to produce a 55% lactulose syrup at a rate of 93 kilograms per hour (563359 kg year−1) was $5.20 per kilogram ($2.36 per pound). These costs, which do not include packaging or distribution expenses, do include a 25% return on the plant investment. © 1997 SCI.
The role of the membrane in the expression of the vitamin K-dependent enzymes. (1992)

The hemostatic response to vascular damage results in the focal generation of thrombin to produce a fibrin/platelet clot at the site of vascular injury. This regulated hemostatic response derives from the assembly and activity of enzyme complexes that are localized to surfaces presented by the vascular damage. The product of each enzymatic complex provides the serine protease component required for the assembly and activity of each successive enzyme complex, ultimately leading to the formation of thrombin. When one limits attention to those complexes clearly associated with hemostatic or thrombotic risk, the significance of the vitamin K-dependent enzyme complexes becomes apparent. Each of these complexes involves a serine protease and a cofactor protein that assemble on a membrane surface in the presence of Ca++. The expression of an active complex involves, in addition to the activation of a zymogen to an enzyme, the presentation or activation of a cofactor protein and the provision of the appropriate membrane to support the reaction. The membrane plays an essential part in the formation and expression of vitamin K-dependent complexes; thus, its regulation is vital in the expression of procoagulant activity.
MPPT of Grid-Tied Dual-PV LLC Converter using Adaptive Neuro Fuzzy Interface System (2022)

This paper proposes an Adaptive Neuro- Fuzzy Interface System (ANFIS) based closed-loop model for achieving maximum efficiency of a grid-tied phase-shifted dual-input LLC converter. The algorithm can extract maximum power from Photovoltaic (PV) panels even under dynamic weather conditions. The ANFIS generates switching frequency and phase shift to regulate the power flow using both Switching Frequency Modulation (SFM) and Phase Shift Modulation (PSM). The ANFIS model uses the LLC converter's DC gain equations to train the neural network while the fuzzy rules ensure the optimum output using membership functions. A grid controller on the other hand maintains the DC link voltage to a certain level, ensuring the grid current injection with less harmonics. The simulation is performed using the MATLAB/Simulink platform and compared with other Maximum Power Point Tracking (MPPT) methods. Finally, a 400-W prototype of the converter was built and tested to verify the theoretical analysis.
High Performance Feature Detection on a Reconfigurable Co-Processor (2006)

In this paper, the authors propose a new design for feature detection used for tracking, which eliminates the need of a central computer to complete computations for the feature selection algorithm. Such a system constrains performance due to the delay in which data is transferred from camera to computer for processing. Our design suggests that feature detection computation can be done on a processor within the camera helping to reduce overall computation time for detection and increase performance for overall tracking system. However, these systems are often constrained by the processing power available to the camera. But with Benedetti and Perona's approach to Tomasi and Kanade's detection algorithm, such a design is possible to implement onto a camera system which would eliminate the delay and also improve performance over a tracking system designed on software
Design of Tracking Controller for Holographic Digital Data Storage (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Neoadjuvant accelerated MVAC (AMVAC) in patients with muscle invasive bladder cancer: Results of a multicenter phase II study. (2012)

4526 Background: Standard methotrexate, vinblastine, doxorubicin and cisplatin (MVAC) demonstrates a survival benefit in the neoadjuvant setting for patients (pts) with muscle invasive bladder cancer (MIBC). Compared with standard MVAC, AMVAC yielded higher response rates with less toxicity in the metastatic setting. Methods: Pts with MIBC, cT2-T4a, and N0-N1 with CrCl &gt;=50 and adequate hepatic and marrow function were eligible. Pts received 3 cycles of AMVAC (methotrexate 30 mg/m 2 , vinblastine 3 mg/m 2 , doxorubicin 30 mg/m 2 , cisplatin 70mg/m 2 ) on day 1, with pegfilgrastim 6 mg day 2 or 3, every 2 weeks. Pts with CrCl &lt; 60 could receive cisplatin split over 2 days. Radical cystectomy (RC) with lymph node dissection was performed 4-8 weeks after the last dose of chemotherapy. Primary endpoint was pathologic complete response (pCR) rate. Results: Accrual is complete with 44 MIBC pts enrolled at 2 institutions (FCCC, TJU) over a 25 month period. Median age 64 (range 45-83). Three withdrew from study early and are not evaluable for response (2 physician discretion, 1 withdrawal of consent). An additional 8 are currently receiving treatment on study with toxicity and response data pending. Of the 33 evaluable pts for whom final data is available, 30 received all 3 cycles of AMVAC at full dose. Three pts received &lt; 3 cycles due to grade 3 fatigue (1), low platelets (1), and disease progression precluding RC (1). 32/33 pts underwent RC, all within 8 weeks of last chemotherapy. Median time from start of chemotherapy to RC was 9.7 wks (range 4.6-13 wks). 13/33 pts (39.4%, 95% CI, 22.7-56.1%) had a pCR. An additional 3 (9.1%) were downstaged to non muscle invasive disease. For the intent to treat cohort (n=36) 8 pts had grade 3-4 AMVAC related adverse events, the most common being anemia (3), fatigue (3) and neutropenia (2) and overall pCR rate was 36.1%. (95% CI, 20.4-51.8%). All pts will have completed study treatment by April 2012. Final results will be presented. Conclusions: Neoadjuvant AMVAC is well tolerated and preliminary results show a pCR rate similar to that reported for standard 12-week MVAC, suggesting that AMVAC for three cycles (6 weeks) is a safe and efficient alternative.
Proteomic differences in the hippocampus and cortex of epilepsy brain tissue (2021)

Epilepsy is a common neurological disorder affecting over 70 million people worldwide, with a high rate of pharmaco-resistance, diverse comorbidities including progressive cognitive and behavioural disorders, and increased mortality from direct (e.g. sudden unexpected death in epilepsy, accidents, drowning) or indirect effects of seizures and therapies. Extensive research with animal models and human studies provides limited insights into the mechanisms underlying seizures and epileptogenesis, and these have not translated into significant reductions in pharmaco-resistance, morbidities or mortality. To help define changes in molecular signalling networks associated with seizures in epilepsy with a broad range of aetiologies, we examined the proteome of brain samples from epilepsy and control cases. Label-free quantitative mass spectrometry was performed on the hippocampal cornu ammonis 1-3 region (CA1-3), frontal cortex and dentate gyrus microdissected from epilepsy and control cases (<i>n</i> = 14/group). Epilepsy cases had significant differences in the expression of 777 proteins in the hippocampal CA1 - 3 region, 296 proteins in the frontal cortex and 49 proteins in the dentate gyrus in comparison to control cases. Network analysis showed that proteins involved in protein synthesis, mitochondrial function, G-protein signalling and synaptic plasticity were particularly altered in epilepsy. While protein differences were most pronounced in the hippocampus, similar changes were observed in other brain regions indicating broad proteomic abnormalities in epilepsy. Among the most significantly altered proteins, G-protein subunit beta 1 (GNB1) was one of the most significantly decreased proteins in epilepsy in all regions studied, highlighting the importance of G-protein subunit signalling and G-protein-coupled receptors in epilepsy. Our results provide insights into common molecular mechanisms underlying epilepsy across various aetiologies, which may allow for novel targeted therapeutic strategies.
Fast forming of multistacked UD prepreg using a high‐pressure process (2019)

In this article, the opportunities of fast forming of multistacked UD prepreg when using high‐pressure forming were examined in an experimental study. Forming is often considered a bottleneck in manufacturing of composite aircraft parts and speeding up the process is, therefore, of great interest. A Quintus Flexform fluid cell press was used to create pressure of 100 to 400 bars. In the study, different lay‐up sequences and thicknesses were tested for manufacturing of c‐shaped coupons. Tests were performed at different temperatures and some of the samples were sandwiched with mild steel sheets referred to as a steel sheet dummy. A case study was also performed on a double‐curved spar geometry. It was found that forming at a relatively high overall pressure level combined with an elevated temperature, created squeeze flow‐related wrinkle formations, and radius thinning. With high pressure forming, material compression/compaction mechanisms showed to have great influence on the forming result. This differs to low pressure vacuum forming, where intraply shear, interply shear, and ply bending are the dominant forming mechanisms. The steel sheet dummy minimized the squeeze flow related wrinkle in the web and flanges. Instead the forming temperature was found to exert the greatest influence on radius thinning. When forming at room temperature, radius thinning was almost eliminated and instead bending‐related wrinkles in the flange below the radii appeared. POLYM. COMPOS., 40:3550–3561, 2019. © 2019 Society of Plastics Engineers
Room temperature deposition of silicon by arrayed DC microplasmas (2004)

This paper reports room temperature deposition of silicon in spatially localized areas of a micro-chip through plasma-enhanced chemical vapor deposition (PECVD) using micro-plasmas. DC microplasmas are generated on a patterned Ti arrayed electrode structure employing multiple cathodes and a single anode. At the operating pressures used, the plasma glow is confined to the region directly over the powered cathodes only. Powering these microplasmas in a silane ambient allows selected deposition of silicon to only the energized cathodes. Silicon is deposited at 6.7-15.9 nm/min. corresponding to microplasma cathode power densities of 3.65-9.35 W/cm/sup 2/, with the substrate heated to 300/spl deg/C. At room temperature deposition rates up to 7.5 nm/min. are realized. A new plasma coupling technique for creating controlled variations in a sub-array of unbiased electrodes is also described.
Down-Conversion of Microwave Optoelectronic Signals in a GaAs Microstrip Ring Resonator (1996)

We report the mixing performance of a GaAs microstrip ring resonator in which a Schottky photodetector is monolithically integrated in a coupling gap. A spectrum of down-conversion between an optically modulated RF signal and an independently applied LO (Local Oscillator) signal is demonstrated and the system conversion loss of RF to IF (Intermediate Frequency) is measured as a function of LO frequency and compared with other data.
The Extended Mid-Infrared Structure of the Circinus Galaxy (2004)

We present subarcsecond resolution mid-IR images of the Circinus galaxy at 8.74 and 18.33 μm. We resolve extended emission at both wavelengths, extending ∼2″ from each side of the nucleus in an approximate east-west direction. These extensions are spatially coincident with previously detected compact (∼30 pc) V-shaped [O III] emission extending northwest of the nucleus as well as countercone [Si vi] emission, emission at these wavelengths interpreted as delineating the interface between inflowing material and the ionization cone. We detect no extended mid-IR emission associated with the structure responsible for collimating the ionizing photons (i.e., obscuring torus or disk of material), limiting the flux density of the obscuring structure to ≤0.27 mJy or a diameter of ≤0″.20 (≤4 pc).
Electrospun Fiber Mesh for High-Resolution Measurements of Oxygen Tension in Cranial Bone Defect Repair (2019)

Tissue oxygenation is one of the key determining factors in bone repair and bone tissue engineering. Adequate tissue oxygenation is essential for survival and differentiation of the bone-forming cells and ultimately the success of bone tissue regeneration. Two-photon phosphorescence lifetime microscopy (2PLM) has been successfully applied in the past to image oxygen distributions in tissue with high spatial resolution. However, delivery of phosphorescent probes into avascular compartments, such as those formed during early bone defect healing, poses significant problems. Here, we report a multifunctional oxygen-reporting fibrous matrix fabricated through encapsulation of a hydrophilic oxygen-sensitive, two-photon excitable phosphorescent probe, PtP-C343, in the core of fibers during coaxial electrospinning. The oxygen-sensitive fibers support bone marrow stromal cell growth and differentiation and at the same time enable real-time high-resolution probing of partial pressures of oxygen via 2PLM. The hydrophilicity of the probe facilitates its gradual release into the nearby microenvironment, allowing fibers to act as a vehicle for probe delivery into the healing tissue. In conjunction with a cranial defect window chamber model, which permits simultaneous imaging of the bone and neovasculature in vivo via two-photon laser scanning microscopy, the oxygen-reporting fibers provide a useful tool for minimally invasive, high-resolution, real-time 3D mapping of tissue oxygenation during bone defect healing, facilitating studies aimed at understanding the healing process and advancing design of tissue-engineered constructs for enhanced bone repair and regeneration.
The Efficacy of Retrobulbar Block Anesthesia Only in Pars Plana Vitrectomy and Transconjunctival Sutureless Vitrectomy (2008)

Vitreoretinal surgery, particularly 25-gauge transconjunctival sutureless vitrectomy, can be safely and efficiently performed under retrobulbar block anesthesia only. Retrobulbar block anesthesia only could become a more acceptable anesthesia for vitreoretinal surgery for selected patients.
Oriented Single-Crystal LiTaO<inf>3</inf> Thin Film on Silicon for High Performances SAW Components (2018)

This paper investigates advanced piezoelectric-on-insulator (POI) substrates elaborated using the Smart Cut™ technology to transfer a thin, high uniformity, single-crystal LiTaO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> layer on top of a silicon handle wafer. These POI substrates enable the development of high quality surface acoustic wave (SAW) devices. Single-port test resonator have been built on such wafers, reaching Bode Q in excess of 1700 and coupling factors above 8 %, as the result of guided mode propagation. Resonance frequency dispersion was measured as low as 0.64 %. The thin layer stack also improves TCF down to 5.8 ppm/°C compared with conventional bulk LiTaO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> technology and can be further reduced at desired frequencies by optimizing the multi-layer stack thicknesses.
Luteolysis Induced by Prostaglandin F2agr Before and After Hysterectomy in Heifers (1977)

In a Latin Square design, each of 6 heifers was given (im) 5, 10 and 15 mg PGF20 during diestrus during three consecutive estrous cycles. Then the uterus and cervix were removed. Thirty to 45 days after surgery, each hysterectomized heifer was given 30 mg PGF3 � to induce estrus before the same experimental doses of PGF20 were resumed at 15-day intervals beginning 10 to 12 days after this induced estrus. Ten and 15 mg PGF20 were luteolytic in 10 of 12 heifers before and after hysterectomy. While 5 mg PGF3 � was not luteolyticin intactheifers,it caused luteolysis in three of four heifers after hysterectomy. Thus, the uterus is not required for luteolysis induced by exogenous PGF20 in heifers. To the contrary, the uterus may interfere with luteolysis induced by PGF20. Serum (jugular) progesterone changes were similarforthe first 6 h after 5, 10 or 15 mg PGF20 in heifers before and after hysterectomy, whether or not PGF2 � was luteolytic. After the first 6 h, progesterone remained elevated at about 60 percent of pretreatment values in heifers which did not exhibit estrous behavior, while progesterone declined to less than 1 ng/ml within 36 h in heifers which exhibited estrus. Following the initial rapid decline in progesterone, serum LH doubled within 3 h after administration of PGF20 and LH remained elevated until 6 h in all heifers; it returned to pretreatment values within 12 to 24 h when heifers exhibited no estrus, but it remained elevated when PGF20 was luteolytic. Serum estradiol increased within 18 h when PGF20 was luteolytic, and estrus began at 78 ± 5 h in these heifers. There was no rise in serum estradiol when heifers failed to exhibit estrus after PGF2 �. Thus, beginning within 18 h, elevated estrogen secretion may participate in the Iuteolysis begun by exogenous PGF2 �. Serum testosterone was unaffected by PGF20 injections before or after hysterectomy.
High-Pressure Sequence ofBa3NiSb2O9Structural Phases: NewS=1Quantum Spin Liquids Based onNi2+ (2011)

Two new gapless quantum spin-liquid candidates with S = 1 (Ni(2+)) moments: the 6H-B phase of Ba(3)NiSb(2)O(9) with a Ni(2+)-triangular lattice and the 3C phase with a Ni(2/3)Sb(1/3)-three-dimensional edge-shared tetrahedral lattice were obtained under high pressure. Both compounds show no magnetic order down to 0.35 K despite Curie-Weiss temperatures θ(CW) of -75.5 (6H-B) and -182.5 K (3C), respectively. Below ~25 K, the magnetic susceptibility of the 6H-B phase saturates to a constant value χ(0) = 0.013 emu/mol, which is followed below 7 K by a linear-temperature-dependent magnetic specific heat (C(M)) displaying a giant coefficient γ = 168 mJ/mol K(2). Both observations suggest the development of a Fermi-liquid-like ground state. For the 3C phase, the C(M) perpendicular T(2) behavior indicates a unique S = 1, 3D quantum spin-liquid ground state.
Comprehensive Cohort Analysis of Mutational Spectrum in Early Onset Breast Cancer Patients (2020)

Early onset breast cancer (EOBC), diagnosed at age ~40 or younger, is associated with a poorer prognosis and higher mortality rate compared to breast cancer diagnosed at age 50 or older. EOBC poses a serious threat to public health and requires in-depth investigation. We studied a cohort comprising 90 Taiwanese female patients, aiming to unravel the underlying mechanisms of EOBC etiopathogenesis. Sequence data generated by whole-exome sequencing (WES) and whole-genome sequencing (WGS) from white blood cell (WBC)-tumor pairs were analyzed to identify somatic missense mutations, copy number variations (CNVs) and germline missense mutations. Similar to regular breast cancer, the key somatic mutation-susceptibility genes of EOBC include <i>TP53</i> (40% prevalence), <i>PIK3CA</i> (37%), <i>GATA3</i> (17%) and <i>KMT2C</i> (17%), which are frequently reported in breast cancer; however, the structural protein-coding genes <i>MUC17</i> (19%), <i>FLG</i> (16%) and <i>NEBL</i> (11%) show a significantly higher prevalence in EOBC. Furthermore, the top 2 genes harboring EOBC germline mutations, <i>MUC16</i> (19%) and <i>KRT18</i> (19%), encode structural proteins. Compared to conventional breast cancer, an unexpectedly higher number of EOBC susceptibility genes encode structural proteins. We suspect that mutations in structural proteins may increase physical permeability to environmental hormones and carcinogens and cause breast cancer to occur at a young age.