gebhart/patrepeval huggingface dataset:
Bacterial ligands in the rehabilitation of healthcare workers after COVID-19 (2022)

Immune defense mechanisms in survivors of the COronaVIrus Disease-19 (COVID-19) and development of their rehabilitation during the pandemic both portray a great scientific and practical interest. The aim of the study was to explore effect of Immunovac-VP-4® (I-VP-4), a vaccine based on bacterial ligands, on the clinical and airway mucosal immunity parameters, along with systemic immune response in a group of medical workers in post-COVID period and in persons who did not develop the disease. Methods . 82 healthcare workers aged from 18 to 65 years were included in a prospective open controlled study. The participants were divided into 4 groups: groups 1 (n = 20) and 2 (n = 27) included those with a history of COVID-19, and groups 3 (n = 18) and 4 (n = 17) included those who did not have the disease. Volunteers in groups 1 and 3 received I-VP-4. Samples of oral fluid, induced sputum, nasopharyngeal and oropharyngeal mucosa scrapings, and venous blood were examined. The levels of total secretory immunoglobulin class A (sIgA) and immunoglobulin G (IgG) were determined by enzyme immunoassay. The phagocytic index (PI) of leukocytes was assessed by flow cytometry. Results . The group of patients who did not have COVID-19 and received IVP-4 (Group 3) showed a tendency to a smaller number of COVID-19 cases, as well as some reduction in days of incapacity for work due to the acute respiratory infections (ARI). The vaccine improved airway mucosal immunity parameters and innate immune response. sIgA increased in the induced sputum (p &lt; 0.005) and unchanged in the oropharyngeal mucosa samples in Group 1. The PI of macrophages in oral fluid doubled (p &lt; 0.05) in this group. At the same time, those parameters decreased in Group 2. In non-infected vaccinated patients (Group 3), a significant increase of PI of blood monocytes was found on the day 90 of the study (p &lt; 0.05). Also, a four-fold increase of PI of macrophages in oral fluid in comparison with Group 4 (p &lt; 0.05) was noted. Conclusion . I-VP-4 improved airway mucosal immunity mechanisms and the systemic immune response. The vaccine can be recommended for rehabilitation programs for COVID-19 survivors and for prevention of ARIs.
Software-defined Radios to Accelerate mmWave Wireless Innovation (2019)

Imagine a dystopian world in which pianists did not have access to pianos. They would dream up sheet music, and have a computer simulate a recital. They would then go to their premier conference PianoCom to present a paper on their novel sheet music; and perhaps even spend the evening arguing about whose sheet music was more pleasing to the ears.
The radiologically isolated syndrome (2008)

Neurologists frequently consult on patients who have had asymptomatic white matter T2 hyperintensities discovered incidentally on brain MRI. The consult often comes with the question “Does this person have multiple sclerosis (MS)?” Usually the patient has nothing clinically to indicate MS, the pattern of white matter changes is not suggestive of MS, and the T2 hyperintensities can be attributed to another cause.1 However, occasionally the patient has no signs or symptoms of MS but the appearance of the white matter abnormalities on MRI are highly suggestive of MS. What is our diagnosis for such patients and do we treat them for MS?

In this issue of Neurology ®, Okuda et al.2 describe a cohort of subjects who had an initial brain MRI highly suggestive of MS but no signs or symptoms of the illness. They propose calling this condition the radiologically isolated syndrome (RIS). The cohort consisted of 44 individuals. All had a baseline brain MRI with ovoid foci of white matter T2 hyperintensities and met at least three of four of the Barkhof criteria …
Chiral resolution of multichiral center racemates by different modalities of chromatography (2016)

It is a continuous chase of researchers to separate chiral racemates due to their dominance in the pharmaceutical industry, agrochemicals, and food additives. There are many analytical techniques which have been used to resolve one chiral center racemates, but, little the literature report is scanty for the resolution of multiple stereogenic center racemates. Therefore, in this article the efforts were made to describe the enantiomeric resolution of multiple stereogenic center racemates by different modalities of chromatography. The various modalities discussed are high-performance liquid chromatography, capillary electrophoretic chromatography, miceller electrokinetic chromatography, supercritical fluid chromatography, nanoliquid chromatography, and gas chromatography. Besides, the attempts have also been made to discuss the future challenges and prospectives of the enantiomeric resolution of multichiral racemates.
Development and reproduction ofSpodoptera eridania(Lepidoptera: Noctuidae) and its egg parasitoidTelenomus remus(Hymenoptera: Platygastridae) on the genetically modified soybean (Bt) MON 87701×MON 89788 (2014)

Genetically modified crops with insect resistance genes from Bacillus thuringiensis Berliner (Bt-plants) are increasingly being cultivated worldwide. Therefore, it is critical to improve our knowledge of their direct or indirect impact not only on target pests but also on non-target arthropods. Hence, this study evaluates comparative leaf consumption and performance of Spodoptera eridania (Cramer), a species that is tolerant of the Cry1Ac protein, fed with Bt soybean, MON 87701×MON 89788 or its near [corrected] non-Bt isoline. Using this species as a model, we assessed [corrected] the comparative performance of the egg parasitoid Telenomus remus Nixon on eggs of S. eridania produced from individuals that fed on these two soybean genotypes [corrected] as larvae. Results showed that Bt soybean did not affect pest foliage consumption, but did reduce larvel duration by two days despite larvae in both treatments having six instars. Nevertheless, survival of S. eridania larvae, pupal weight, sex ratio, fecundity and longevity of female moths, and egg viability did not differ between Bt and non-Bt soybeans. Adult longevity of S. eridania males was increased when caterpillars were fed with Bt soybean versus the near isoline. No adverse effects of this technology were observed for the egg parasitoid T. remus. [corrected].
C−H Bond Functionalization via Hydride Transfer: Synthesis of Dihydrobenzopyrans from ortho-Vinylaryl Akyl Ethers (2009)

The hydride transfer initiated cyclization ("HT-cyclization") of aryl alkyl ethers, which leads to direct coupling of sp(3) C-H bonds and activated alkenes, is reported. Readily available salicylaldehyde derived ethers are converted in one step to dihydrobenzopyrans, an important class of heteroarenes frequently found in biologically active compounds. This process has not been previously reported, in contrast to known HT-cyclizations of the corresponding tert-amines ("tert-amino effect" reactions).
MP20-16 68 GA-PSMA-11 PET/CT VS 18 F-FLUCICLOVINE PET/CT: A CASE SERIES IN PROSTATE CANCER PATIENTS WITH BIOCHEMICAL RECURRENCE (2018)

16.79AE4.68) lesions. However, PSMA based PET/CT was not sensitive for lung metastatic lesions compared to 18 F-FDG PET/CT. CONCLUSIONS: PSMA based PET/CT imaging provided great diagnostic value on RCC. Compared to traditional 18 F-FDG PET/CT, PSMA was more sensitive in primary lesions, bone and lymph node metastasis. But PSMA PET/CT was not as good as 18 FDG PET/CT for lung metastatic lesions.
Ceramic Plasmonic Components for Optical Metamaterials (2011)

The performance of metamaterial and transformation-optics devices is limited by losses in their plasmonic components. We show that ceramics (heavily doped-zinc oxide and titanium nitride) could help in overcoming the loss issue in the optical range.
Three-Dimensional Simulation of Warp-knitted Fabric (2009)

With detailed research on the structure of warp-knitted fabric, the spatial yarn position of a 3D loop structure was discussed, and the dimension of each parameter was ascertained. After establishing the basic control points of the loop, a 3D model of warp-knitted fabric was created. By calculating the control points of this model in reverse, a more exact control polygon was attained. By utilising the program Visual C++ and the developing tools of Open GL, using Non-Uniform Rational B-Spline surfaces, spatial yarn can be described exactly, and a virtual reality of warp-knitted fabric can be realised on a computer screen.
Dynamic operation of carrier signal injection based sensorless, direct field oriented AC drives (2003)

This paper analyzes the dynamic operation of carrier signal based sensorless, field oriented AC motor drives. The effects of the harmonics introduced by the fundamental current transients at frequencies near the carrier signal frequency are first analyzed, then compensation based on a fundamental current observer is proposed. The utilization of such a fundamental current observer provides the possibility of modifying the analog to digital conversion process to increase the number of bits effectively containing spatial information and thereby substantially increasing the accuracy of the estimated rotor position or flux angle.
ChemInform Abstract: Synthesis of Solid 2‐Pyridylzinc Reagents and Their Application in Negishi Reactions. (2014)

Abstract Two new varieties of solid, moderately air‐stable 2‐pyridylzinc reagents are explored as alternatives to unstable or unreliable 2‐pyridylboron reagents.
Electrification Annual Progress Report (FY2019) (2020)

During fiscal year 2019 (FY 2019), the U.S. Department of Energy (DOE) Vehicle Technologies Office (VTO) funded early stage research & development (R&D) projects that address Batteries and Electrification of the U.S. transportation sector. The VTO Electrification Sub-Program is composed of Electric Drive Technologies, and Grid Integration activities. The Electric Drive Technologies group conducts R&D projects that advance electric motors and power electronics technologies. The Grid and Charging Infrastructure group conducts R&D projects that advance grid modernization and electric vehicle charging technologies. This document presents a brief overview of the Electrification Sub-Program and progress reports for its R&D projects. Each of the progress reports provide a project overview and highlights of the technical results that were accomplished in FY 2019.
Investigating Therapeutic Strategies for Fragile X Syndrome in Mice (2012)

Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and a leading cause of autism. The identification of the mutation underlying the disease two decades ago has allowed the generation of a mouse model, the Fmr1 knock-out, which presents behavioral, anatomical and biochemical alterations similar to the ones observed in the human condition. The rodent disease model with strong construct and face validity has been essential for our current understanding of the pathophysiology and remains an indispensable tool for testing therapeutic hypotheses. Two interventions targeting the metabotropic glutamate receptor 5 (mGlu5) and the GABA-B receptor, respectively, have been reported to correct a broad range of FXS phenotypes in Fmr1 knockout mice. It is of great interest how these findings obtained from the FXS mouse model may translate into ongoing clinical research testing mGlu5 inhibitors and a GABA-B agonist in patients.
Effect of linear cutting energy on coloration of paper in laser cutting of paper material (2011)

Laser technology has been used in processing of paper materials for 30 years. During its development, this technology has been confronted with difficulties in industrial application for paper industry. One of the main problems in laser cutting process is coloration of paper material during and after cutting. Coloration of paper material can appear due to influence of several factors, such as heat and light, which can cause changes in chemical, physical, optical and mechanical properties of paper surface. In this study it was assumed that energy required for successful laser cutting has to be pre-calculated in order to eliminate energy oversupply. A simple mathematical model found from literature was used for calculation of required cutting energy. This model took into account such parameters as paper grade, sample thickness and specific heat of paper. Due to this, cutting energy can be calculated and estimated for paper samples of different composition and consequently with different properties. Paper samples with different composition were laser cut with different parameters. Optical characteristics, such as yellowness, changes in yellow-blue hue and green-red hue, of laser cut paper samples were measured during 12 day of storage time in controlled laboratory conditions. Paper material samples were cut by Trumpf TLF 2700 HQ CO2 laser, with clean pressured air as cutting gas. This study was carried out in Lappeenranta University of Technology (Finland).
Sjögren’s syndrome-associated SNPs increase GTF2I expression in salivary gland cells to enhance inflammation development (2021)

Sjögren's syndrome (SS) is an autoimmune disease characterized by inflammation with lymphoid infiltration and destruction of the salivary glands. Although many genome-wide association studies have revealed disease-associated risk alleles, the functions of the majority of these alleles are unclear. Here, we show previously unrecognized roles of GTF2I molecules by using two SS-associated single nucleotide polymorphisms (SNPs), rs73366469 and rs117026326 (GTF2I SNPs). We found that the risk alleles of GTF2I SNPs increased GTF2I expression and enhanced nuclear factor-kappa B (NF-κB) activation in human salivary gland cells via the NF-κB p65 subunit. Indeed, the knockdown of GTF2I suppressed inflammatory responses in mouse endothelial cells and in vivo. Conversely, the over-expression of GTF2I enhanced NF-κB reporter activity depending on its p65-binding N-terminal leucine zipper domain. GTF2I is highly expressed in the human salivary gland cells of SS patients expressing the risk alleles. Consistently, the risk alleles of GTF2I SNPs were strongly associated with activation of the IL-6 amplifier, which is hyperactivation machinery of the NF-κB pathway, and lymphoid infiltration in the salivary glands of SS patients. These results demonstrated that GTF2I expression in salivary glands is increased in the presence of the risk alleles of GTF2I SNPs, resulting in activation of the NF-κB pathway in salivary gland cells. They also suggest that GTF2I could be a new therapeutic target for SS.
Highly Effective Polymerization of Acrylate Catalyzed by a “Constrained Geometry” Titanium Complex/B(C6F5)3 System (2007)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTHighly Effective Polymerization of Acrylate Catalyzed by a "Constrained Geometry" Titanium Complex/B(C6F5)3 SystemBing Lian, Christophe M. Thomas, Christophe Navarro, and Jean-François CarpentierView Author Information Catalyse et Organométalliques, UMR 6226, University of Rennes 1, 35042 Rennes Cedex, France, and Arkema, Lacq Research Center, Po Box 34, 64170 Lacq, France Cite this: Macromolecules 2007, 40, 7, 2293–2294Publication Date (Web):March 3, 2007Publication History Received23 February 2007Published online3 March 2007Published inissue 1 April 2007https://pubs.acs.org/doi/10.1021/ma070465ahttps://doi.org/10.1021/ma070465arapid-communicationACS PublicationsCopyright © 2007 American Chemical SocietyRequest reuse permissionsArticle Views362Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Copolymerization,Copolymers,Monomers,Organic compounds,Polymerization Get e-Alerts
Synthesis of 2‐(Chlorodifluoromethyl)indoles for Nucleophilic Halogen Exchange with [18F]Fluoride (2021)

Abstract The synthesis of 2‐[ 18 F]trifluoromethylated indoles from the corresponding chlorodifluoromethyl precursors was found to proceed under milder conditions when compared to known metal‐free nucleophilic exchange reactions with [ 18 F]fluoride on chlorodifluoro‐methyl arenes. A key element in the reaction course is – most likely – a favorable elimination‐addition mechanism on the 2‐methyl position of the indole. Given the increasing interest in 18 F‐labelled compounds, this single step labeling methodology nicely complements the so far existing routes to 2‐[ 18 F]trifluoromethylated indoles.
Generation of RGB EVG stained image from hyperspectral H and E stained image using generative adversarial network (GAN) (2023)

Quantifying elastic fiber in the tissue specimen is an important aspect of diagnosing different diseases. In conventional pathology, special staining technique such as EVG (Verhoeff’s Van Gieson) is applied physically for this purpose which is expensive and time-consuming procedure. Though H&E (Hematoxylin and Eosin) staining is routinely used, less expensive and most common tissue staining technique, elastic and collagen fibers cannot be differentiated using it. This study proposes a modified CycleGAN based unsupervised method for the computerized generation of RGB EVG stained tissue from hyperspectral H&E stained one to save the time and cost of conventional EVG staining procedure. Our proposed method is designed to utilize the sufficient spectral information provided by the H&E hyperspectral image (HSI) without reducing the spectral dimension. For doing so, we have faced challenges to calculate one of the training losses (identity loss) of CycleGAN that requires reducing the channel dimension of H&E HSI to be the same as RGB EVG stained image. We have addressed the issue by adopting intentionally designed three basis functions that can reduce the channel dimension of HSI into three without losing the essential color of elastic fibers. The set of this function includes Linear Discriminant Function (LDF) and the transmittance spectrum of Eosin and Hematoxylin which has proved to best preserve the underlying important features of EVG stained image while reducing the dimensionality of hyperspectral H&E. The experimental result proves the feasibility of our proposed method to generate realistic EVG stained image from its corresponding H&E stained one.
Chemotherapy plus Rituximab versus chemotherapy alone for B-cell non-Hodgkin's lymphoma (2002)

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To determine the efficacy of a combination chemotherapy and the chimeric monoclonal anti‐CD20 antibody Rituximab versus chemotherapy alone in respect to overall survival (OS) and freedom from treatment failure (FFTF). Due to the current small yield of randomised trials in the other areas of combination regimens with immunotherapy, e.g. radio‐immunotherapy, these will not be included in this meta‐analysis. The reason being, in the opinion of the reviewers, is that it remains doubtful whether a clearer answer to the formulated clinical question will be obtained if to many different therapeutic modalities are specified in subgroups in this point in time.
Proceedings of the International Symposium on Low Power Electronics and Design (2018)

The International Symposium on Low Power Electronics and Design is the premier forum for presentation of recent advances in all aspects of low power design and technologies, ranging from process and circuit technologies, simulation and synthesis tools, to system level design and optimization.
<title>Simultaneous true-time-delay beam-forming for all angles of arrival in a phased array antenna</title> (1996)

We present on the use of coherent optical beam combining and signal processing in a fiber-optic phased-array-antenna systems. Mutually coherent links lose phase registration after the signals propagate through the fiber path lengths subject to thermal and stress-induced variations. These path length changes can be compensated with phase corrections to the optical carrier in tan AM or PM modulated signal. In a true time delay fiber optical feed subsystem, the phase corrected outputs can be coherently combined to allow a lens to collect almost all the main beam energy into a single mode output, leading to substantially improved noise figure and dynamic range.
Controlling the rotational and hyperfine state of ultracoldRb87Cs133molecules (2016)

We demonstrate coherent control of the rotational and hyperfine state of ultracold, chemically stable $^{87}\mathrm{Rb}^{133}\mathrm{Cs}$ molecules with external microwave fields. We create a sample of $\ensuremath{\sim}2000$ molecules in the lowest hyperfine level of the rovibronic ground state $N=0$. We measure the transition frequencies to eight different hyperfine levels of the $N=1$ state at two magnetic fields $\ensuremath{\sim}23$ G apart. We determine accurate values of rotational and hyperfine coupling constants that agree well with previous calculations. We observe Rabi oscillations on each transition, allowing complete population transfer to a selected hyperfine level of $N=1$. Subsequent application of a second microwave pulse allows the transfer of molecules back to a different hyperfine level of $N=0$.
Allowing Shared Libraries While Supporting Hardware Isolation in Multicore Real-Time Systems (2017)

The desire to support real-time applications on multicore platforms has led to intense recent interest in techniques for reducing memory-related hardware interference. These techniques typically rely on mechanisms that ensure per-task isolation properties with respect to cache and memory accesses. In most prior work on such techniques, any sharing of memory pages by different tasks is defined away, as sharing breaks isolation. In reality, however, sharing is common. In this paper, one source of sharing is considered, namely, the usage of shared libraries. Such sharing can be obviated by statically linking libraries, but this solution can degrade schedulability by exhausting memory capacity. An alternative approach is proposed herein that allows library pages to be shared while preserving isolation properties. This approach is presented in the context of the MC2 framework and a schedulability-based evaluation of it is presented. Such an evaluation must necessarily consider memory-capacity limits. As a secondary contribution, this paper considers such limits for the first time in the context of MC2.
An efficiency-constrained application of a modified Bernstein polynomial for conformal array amplitude excitation optimization (2005)

This paper starts by reviewing a generalized definition of aperture efficiency appropriate for conformal arrays with directional radiating elements. A modified Bernstein polynomial, defined with just five parameters, is introduced which provides a flexible method to specify a variety of smooth unimodal amplitude distributions that are shown to give good side lobe levels and aperture efficiencies. By using particle swarm optimization of the modified Bernstein polynomial parameters constrained to provide a specified aperture efficiency, a family of aperture distributions and corresponding far field patterns is produced mat allows aperture efficiency to be traded for sidelobe level for conformal arrays