gebhart/patrepeval huggingface dataset:
Context Aware Conversational Understanding for Intelligent Agents With a Screen (2018)

We describe an intelligent context-aware conversational system that incorporates screen context information to service multimodal user requests. Screen content is used for disambiguation of utterances that refer to screen objects and for enabling the user to act upon screen objects using voice commands. We propose a deep learning architecture that jointly models the user utterance and the screen and incorporates detailed screen content features. Our model is trained to optimize end to end semantic accuracy across contextual and non-contextual functionality, therefore learns the desired behavior directly from the data. We show that this approach outperforms a rule-based alternative, and can be extended in a straightforward manner to new contextual use cases. We perform detailed evaluation of contextual and non-contextual use cases and show that our system displays accurate contextual behavior without degrading the performance of non-contextual user requests.
Continuous security evaluation and auditing of remote platforms by combining trusted computing and security automation techniques (2013)

In many new distributed systems paradigms such a cloud computing, Internet of Things (IoT), electronic banking, etc. the security of the host platforms is very critical which is managed by the platform owner. The platform administrators use security automation techniques such as those provided by Security Content Automation Protocol (SCAP) standards to ensure that the outsourced platforms are set up correctly and follow the security recommendations (governmental or industry). However, the remote platform users still have to trust the platform administrators. The third party security audits, used to shift the required user trust from the platform owner to a trusted entity, are scheduled and are not very frequent to deal with the daily reported vulnerabilities which can be exploited by the attackers. In this paper we propose a remote platform evaluation mechanism which can be used by the remote platform users themselves, or by the auditors to perform frequent platform security audits for the platform users. We analyze the existing SCAP and trusted computing (TCG) standards for our solution, identify their shortcomings, and suggest ways to integrate them. Our proposed platform security evaluation framework uses the synergy of TCG and SCAP to address the limitations of each technology when used separately.
A poesia popularizante de Vitorino Nemésio (2019)

Abordamos neste artigo a poesia de Festa Redonda, que, radicada nas fontes remotas da iniciação humana e literária de Vitorino Nemésio – quadras e outros géneros literários orais, com os quais conviveu desde a infância –, é uma espécie de macrodiscurso festivo que o acompanhará enquanto poeta de expressão e de conteúdos múltiplos e versáteis.
ChemInform Abstract: CHEMICAL, SPECTRAL, STRUCTURAL, AND CHARGE TRANSPORT PROPERTIES OF THE “MOLECULAR METALS” PRODUCED BY IODINATION OF NICKEL PHTHALOCYANINE (1981)

Abstract Fein gepulvertes Ni‐ "phthalocyanin NiL reagiert mit Iodlösungen oder Ioddampf zu polykristallinen Festkörpern (I) mit unterschiedlichem Iodgehalt.
Electronics Supply Chain Integrity Enabled by Blockchain (2019)

Electronic systems are ubiquitous today, playing an irreplaceable role in our personal lives as well as in critical infrastructures such as power grid, satellite communication, and public transportation. In the past few decades, the security of software running on these systems has received significant attention. However, hardware has been assumed to be trustworthy and reliable "by default" without really analyzing the vulnerabilities in the electronics supply chain. With the rapid globalization of the semiconductor industry, it has become challenging to ensure the integrity and security of hardware. In this paper, we discuss the integrity concerns associated with a globalized electronics supply chain. More specifically, we divide the supply chain into six distinct entities: IP owner/foundry (OCM), distributor, assembler, integrator, end user, and electronics recycler, and analyze the vulnerabilities and threats associated with each stage. To address the concerns of the supply chain integrity, we propose a blockchain-based certificate authority framework that can be used to manage critical chip information such as electronic chip identification (ECID), chip grade, transaction time, etc. The decentralized nature of the proposed framework can mitigate most threats of the electronics supply chain, such as recycling, remarking, cloning, and overproduction.
Interaktiv testmetodik för utvärdering av vardagsljud som upplevs obehagliga med fokus på barn med autism (2007)

Validerat; 20101217 (root)
Web-Based Data Collection: Security Is Only as Good as the Weakest Link (2005)

To the Editor: I read the paper by Avidan et al. (1) with great interest because the World Wide Web is a great communication tool and it is only logical that studies involving multicenter data collection would utilize it. When comparing a web-based method to a single computer data collection method (a database, for example), the biggest difference is the remote data entry and, thus, the communication aspect to the centralized server. Many choices can be made for this communication to occur, but the most convenient and cost-efficient method is to use the Internet as the authors have done. They rightfully point out that, because of this, security is the most critical issue. However, the generally accepted concept that “security is only as good as the weakest link” (2) is not applied to their methods. The authors acknowledge that they send their clinical data via insecure (unencrypted) email to their protected (firewalled) database server. This is similar to locking all the doors to your house but leaving the bathroom window open. The risk of intercepting data from email messages is not minimal. Emails typically flow through several servers (just look at the full headers of any email for “Received:” entries) and the system administrators for each of those systems have access to the emails. In addition, if there is a problem with email delivery (even if it is temporary), bounce messages are sent, and those typically are copied to system administrators. It is relatively easy for hackers to monitor unencrypted data streams. I agree that there is a small chance that a hacker would accidentally find the data stream, but it would be relatively easy to target this setup and to get a lot of data out of it. In the United States, privacy and security of patient health information has been regulated by the Health Insurance Portability and Accountability Act (HIPAA) of 1996, Public Law 104–191. Under this law a setup as presented in this paper would be unacceptable. Electronic, web-based data collection systems can be set up in compliance with HIPAA. Data must be encrypted as it flows through the system. Typically that means a secure SSL-based connection from the web browser on the client to the web server (https connections) and a secure encrypted connection between the web server and the database server. Firewall techniques can be employed as well because the database server only needs to accept connections from the web server. Only by ensuring that data are always encrypted and by maintaining and patching the computers the data reside on can we be reasonably sure that patient health information is private and secure. J. H. van Oostrom, PhD Department of Anesthesiology University of Florida Gainesville, FL [email protected]
Synthesis of Doped/Hybrid Carbon Dots and Their Biomedical Application (2022)

Carbon dots (CDs) are a novel type of carbon-based nanomaterial that has gained considerable attention for their unique optical properties, including tunable fluorescence, stability against photobleaching and photoblinking, and strong fluorescence, which is attributed to a large number of organic functional groups (amino groups, hydroxyl, ketonic, ester, and carboxyl groups, etc.). In addition, they also demonstrate high stability and electron mobility. This article reviews the topic of doped CDs with organic and inorganic atoms and molecules. Such doping leads to their functionalization to obtain desired physical and chemical properties for biomedical applications. We have mainly highlighted modification techniques, including doping, polymer capping, surface functionalization, nanocomposite and core-shell structures, which are aimed at their applications to the biomedical field, such as bioimaging, bio-sensor applications, neuron tissue engineering, drug delivery and cancer therapy. Finally, we discuss the key challenges to be addressed, the future directions of research, and the possibilities of a complete hybrid format of CD-based materials.
Immiscible blend morphology after shear and elongation (2015)

This work examines the role of shear and extensional strain on immiscible blend morphology, namely domain size, orientation, and co-continuity. The domain size reduces with surface tension similar to what is observed with isolated droplets. The domain size is shown to increase with shear strain due to coalescence. Hence the best mixing is found with low shear strains, i.e. low rates of shear and short durations of time. Extensional strain (extrusion draw ratio DR) reduces phase width and thickness with a DR−0.5 dependence, suggesting the transformation to a fibrilar morphology. The critical draw ratio for morphology transformation is approximately 7, in agreement with observations by Grace for droplet breakup in elongation. Fibrilar morphology is also consistent with a large increase in strain-to-break in the drawn film and with observed creep and optical scattering behavior.
High-power high-repetition-rate F 2 lasers for 157-nm lithography (2002)

According to the ITRS-Roadmap, the 157nm wavelength of the F2-laser is the most likely solution to extend the optical lithography for production of ICs with critical dimensions below 70nm down to the 50nm node. The introduction of the 157nm lithography for high volume mass production requires high power, high repetition rate F2-lasers operating in the power range of more than 40W or at repetition rates of more than 4kHz. To meet the narrow time gap for an introduction of the full-field 157nm-scanner systems for real production in the year 2004/5 the community have to solve several challenging issues even in the laser section. F2-laser systems are needed which completely fulfill all specifications of a lithography light source, either for a refractive or a catadioptic projection optics. Verification and precise measurement of the key laser parameters in the VUV usually requires a specific development of the metrology, necessary for this task. In this report we present the progress which had been achieved in the development of high repetition rate high power single-line F2 lasers for catadioptic lithography application. The key features of a F2-laser > 4kHz will be demonstrated. We will also review the main parameters and the performance data from the field of the standard lithography-grade F2020 a 2kHz system which is already applied for pilot scanner tool design. Some improvements of these systems with regard to single line power, dose stability, polarization and gas life will be shown and reliability data from the field will be reviewed. Critical dependence of the spectral properties of the F2-laser emission at 2 kHz and 4 kHz will be discussed. Some new investigations on the coherence properties of the Fluorine laser are also implemented.
Use of Metal Oxide Nanoparticle Band Gap To Develop a Predictive Paradigm for Oxidative Stress and Acute Pulmonary Inflammation (2012)

We demonstrate for 24 metal oxide (MOx) nanoparticles that it is possible to use conduction band energy levels to delineate their toxicological potential at cellular and whole animal levels. Among the materials, the overlap of conduction band energy (E(c)) levels with the cellular redox potential (-4.12 to -4.84 eV) was strongly correlated to the ability of Co(3)O(4), Cr(2)O(3), Ni(2)O(3), Mn(2)O(3), and CoO nanoparticles to induce oxygen radicals, oxidative stress, and inflammation. This outcome is premised on permissible electron transfers from the biological redox couples that maintain the cellular redox equilibrium to the conduction band of the semiconductor particles. Both single-parameter cytotoxic as well as multi-parameter oxidative stress assays in cells showed excellent correlation to the generation of acute neutrophilic inflammation and cytokine responses in the lungs of C57 BL/6 mice. Co(3)O(4), Ni(2)O(3), Mn(2)O(3), and CoO nanoparticles could also oxidize cytochrome c as a representative redox couple involved in redox homeostasis. While CuO and ZnO generated oxidative stress and acute pulmonary inflammation that is not predicted by E(c) levels, the adverse biological effects of these materials could be explained by their solubility, as demonstrated by ICP-MS analysis. These results demonstrate that it is possible to predict the toxicity of a large series of MOx nanoparticles in the lung premised on semiconductor properties and an integrated in vitro/in vivo hazard ranking model premised on oxidative stress. This establishes a robust platform for modeling of MOx structure-activity relationships based on band gap energy levels and particle dissolution. This predictive toxicological paradigm is also of considerable importance for regulatory decision-making about this important class of engineered nanomaterials.
Hard and Soft Capsules: From Branched Polymers to Controlled Release via Gels (2007)

Summary: Supramolecular gels, made from the combination of telechelic poly (ethyleneglycols) (PEG's) and trivalent poly(isobutylenes) with terminal matching hydrogen bonds were prepared and their rheological properties were investigated. Addition of poly(N-isopropylacrylamide) as thermosensitive polymer was included into the gel-capsules in amounts of 10 w%, producing gels with strongly thermally- responsive properties. Additionally, dansyl-dyes with two different endgroups (either an hydrophobic endgroup or a multiple hydrogen bond) were encapsulated into the gels as mimicks for pharmaceutically active substances. Monitoring their diffusion by UV-dependent measurements allowed to tune the diffusion and thus the release properties of the gel. The generated supramolecular gels will allow the selective encapsulation and triggered release of various pharmaceuticals and biologically active targets.
AuraOrb (2006)

One of the problems with notification appliances is that they can be distracting when providing information not of immediate interest to the user. In this paper, we present AuraOrb, an ambient notification appliance that deploys progressive turn taking techniques to minimize notification disruptions. AuraOrb uses eye contact sensing to detect user interest in an initially ambient light notification. Once detected, it displays a text message with a notification heading visible from 360 degrees. Touching the orb causes the associated message to be displayed on the user's computer screen.We performed an initial evaluation of AuraOrb's functionality using a set of heuristics tailored to ambient displays. Results of our evaluation suggest that progressive turn taking techniques allowed AuraOrb users to access notification headings with minimal impact on their focus task.
Maestro (2018)

Instructors of 3D design workshops for children face many challenges, including maintaining awareness of students' progress, helping students who need additional attention, and creating a fun experience while still achieving learning goals. To help address these challenges, we developed Maestro, a workshop orchestration system that visualizes students' progress, automatically detects and draws attention to common challenges faced by students, and provides mechanisms to address common student challenges as they occur. We present the design of Maestro, and the results of a case-study evaluation with an experienced facilitator and 13 children. The facilitator appreciated Maestro's real-time indications of which students were successfully following her tutorial demonstration, and recognized the system's potential to "extend her reach" while helping struggling students. Participant interaction data from the study provided support for our follow-along detection algorithm, and the capability to remind students to use 3D navigation.
The composition of the microbiota modulates allograft rejection (2016)

Transplantation is the only cure for end-stage organ failure, but without immunosuppression, T cells rapidly reject allografts. While genetic disparities between donor and recipient are major determinants of the kinetics of transplant rejection, little is known about the contribution of environmental factors. Because colonized organs have worse transplant outcome than sterile organs, we tested the influence of host and donor microbiota on skin transplant rejection. Compared with untreated conventional mice, pretreatment of donors and recipients with broad-spectrum antibiotics (Abx) or use of germ-free (GF) donors and recipients resulted in prolonged survival of minor antigen-mismatched skin grafts. Increased graft survival correlated with reduced type I IFN signaling in antigen-presenting cells (APCs) and decreased priming of alloreactive T cells. Colonization of GF mice with fecal material from untreated conventional mice, but not from Abx-pretreated mice, enhanced the ability of APCs to prime alloreactive T cells and accelerated graft rejection, suggesting that alloimmunity is modulated by the composition of microbiota rather than the quantity of bacteria. Abx pretreatment of conventional mice also delayed rejection of major antigen-mismatched skin and MHC class II-mismatched cardiac allografts. This study demonstrates that Abx pretreatment prolongs graft survival, suggesting that targeting microbial constituents is a potential therapeutic strategy for enhancing graft acceptance.
Perhaps the Rigorous Modeling of Economic Phenomena Requires Hypercomputation. (2012)

5 Economic Planning and Prediction via Turing-level Actors 9 5.1 Description of Hutter’s AIXI model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 Preliminaries . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 The AIXI Model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 Properties of AIXI . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 5.2 Generalized Economic Planning is an Enriched AIXI Problem . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11
Tumor-targeted delivery of childhood vaccine recall antigens by attenuated Listeria reduces pancreatic cancer (2019)

ABSTRACT Pancreatic ductal adenocarcinoma is highly metastatic, poorly immunogenic, and immune suppression prevents T cell activation in the tumor microenvironment. We developed a microbial-based immunotherapeutic concept for selective delivery of a highly immunogenic tetanus toxoid protein (TT 856-1313 ), into tumor cells by attenuated Listeria monocytogenes , and reactivation of pre-existing TT-specific memory T cells (generated during childhood) to kill infected tumor cells. Thus, TT here functions as an alternative for neoantigens. Treatment of KPC mice with Listeria -TT resulted in TT accumulation in tumors and inside tumor cells, and attraction of predominantly TT-specific memory CD4 T cells. Moreover, gemcitabine (GEM) combined with Listeria-TT significantly improved the migration of CD4 T cells into tumors and the production of perforin and granzyme B, turning cold tumors into immunological hot tumors. In vivo depletion of T cells in Listeria-TT+GEM-treated mice demonstrated CD4 T cell-mediated eradication of tumors and metastases (Mann-Whitney p&lt;0.05). In addition, peritumoral lymph node like structures (LNS) were observed in close contact with the pancreatic tumors displaying CD4 T cells and CD8 T cells of KPC mice treated with Listeria -TT or Listeria -TT+GEM. The production of perforin and granzyme B was observed in LNS of KPC mice that received Listeria -TT+GEM. This combination not only reduced tumor burden (80%) and metastases (87%) significantly (p&lt;0.05, Mann-Whitney), but also improved the survival time of KPC mice with advanced pancreatic cancer substantially (Mantel-Cox p&lt;0.0001). Our results unveil new mechanisms of Listeria and GEM improving immunotherapy for PDAC.
Characterization of a 54-kilodalton human protein kinase recognized by an antiserum raised against the myotonin kinase (1998)

We characterized a 54-kDa human protein kinase recognized by an antiserum raised against the human myotonin protein kinase. This protein kinase displays a serine/threonine kinase activity in the heart and a tyrosine kinase activity in the skeletal muscle. Both kinase activities were attributed to the same 54-kDa protein based on the identity of one-dimensional peptide maps. We showed that the tyrosine kinase activity observed in the skeletal muscle results from a phosphorylation of this protein kinase on tyrosine residues by a tyrosine kinase specifically expressed in this tissue. The tyrosine dephosphorylation of the skeletal muscle 54-kDa protein kinase allowed it to phosphorylate with the highest activity the same peptide substrates as those phosphorylated by the human recombinant myotonin kinase. These results show that a muscle-specific tyrosine phosphorylation event converts a serine/threonine kinase to a tyrosine kinase. They also suggest that the 54-kDa protein kinase is a member of the myotonin kinase family.
IN SITU DETECTION OF THE EPSTEIN-BARR VIRUS-ENCODED NUCLEAR ANTIGEN 1 IN ORAL HAIRY LEUKOPLAKIA AND VIRUS-ASSOCIATED CARCINOMAS (1996)

A new monoclonal antibody has been used to examine immunohistochemically the expression of the Epstein-Barr virus (EBV)-encoded nuclear antigen (EBNA) 1 in virus-associated epithelial lesions. EBNA1 was detected in the tumour cell nuclei of 10/13 undifferentiated nasopharyngeal carcinomas and of 10/10 EBV-associated gastric carcinomas. EBNA1 was also detected in 13 of 16 oral hairy leukoplakia (HL) samples, where its expression was confined to nuclei in the upper epithelial cell layers whilst basal epithelial cells were negative. This observation is in agreement with previous studies demonstrating the absence of latent EBV infection in the basal cell compartment of HL and suggests an essential role for EBNA1, not only in latent EBV infection but also in virus replication.
ASNTR 2018 Abstracts (2018)

Open accessAbstractFirst published online June 1, 2018ASNTR 2018 AbstractsAll Articleshttps://doi.org/10.1177/0963689718765742