gebhart/patrepeval huggingface dataset:
Hydrogen bonding and molecular recognition: synthetic, complexation, and structural studies on barbiturate binding to an artificial receptor (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrogen bonding and molecular recognition: synthetic, complexation, and structural studies on barbiturate binding to an artificial receptorSuk Kyu Chang, Donna Van Engen, Erkang Fan, and Andrew D. HamiltonCite this: J. Am. Chem. Soc. 1991, 113, 20, 7640–7645Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September 1991https://pubs.acs.org/doi/10.1021/ja00020a027https://doi.org/10.1021/ja00020a027research-articleACS PublicationsRequest reuse permissionsArticle Views1382Altmetric-Citations221LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
ELIXIR‐EXCELERATE: establishing Europe's data infrastructure for the life science research of the future (2021)

A new inter-governmental research infrastructure, ELIXIR, aims to unify bioinformatics resources and life science data across Europe, thereby facilitating their mining and (re-)use.
Sub‐wavelength interference pattern from volume plasmon polaritons in a hyperbolic medium (2013)

Abstract Inside of a hyperbolic medium, the principal components of the permittivity tensor have opposite signs causing the medium to exhibit a ‘metallicbr’ type of response to light wave sin one direction, and a ‘dielectric’ response in the other. Our study shows that inside hyperbolic media, volume plasmon polaritons (VPPs) propagate along the characteristic planes, forming distinct, directionally dependent optical responses. This is similar to the propagation of conventional surface plasmon polaritons (SPPs) along the planar interfaces separating the isotropic dielectrics and metallic slabs. Interestingly, the plasmon polariton propagates along the resonance cone in a volume of hyperbolic metamaterial crossing the interfaces of the constitutive materials. The Young's double‐slit scheme is used to study the spatially‐confined diffraction in a hyperbolic slab, made of many thin planar layers of a metal and dielectric, to obtain the sub‐wavelength interference pattern at the output interface. Proof‐of‐concept systems for producing such patterns applicable to nanolithography and subwavelength probes are demonstrated.
Neutral Silicon-Vacancy Center in Diamond: Spin Polarization and Lifetimes (2017)

We demonstrate optical spin polarization of the neutrally charged silicon-vacancy defect in diamond (SiV^{0}), an S=1 defect which emits with a zero-phonon line at 946 nm. The spin polarization is found to be most efficient under resonant excitation, but nonzero at below-resonant energies. We measure an ensemble spin coherence time T_{2}>100 μs at low-temperature, and a spin relaxation limit of T_{1}>25 s. Optical spin-state initialization around 946 nm allows independent initialization of SiV^{0} and NV^{-} within the same optically addressed volume, and SiV^{0} emits within the telecoms down-conversion band to 1550 nm: when combined with its high Debye-Waller factor, our initial results suggest that SiV^{0} is a promising candidate for a long-range quantum communication technology.
Abstract Number ‐ 25: Acute Ischemic Stroke Intervention With Penumbra RED Reperfusion Catheters: Updated Subset Analysis From INSIGHT Registry (2023)

Introduction The prospective INSIGHT Registry is a multicenter ‘multi‐omic’ analysis of thrombi associated with acute hemorrhagic or ischemic stroke. This updated interim analysis evaluated the performance of Penumbra RED catheters used during aspiration thrombectomy for acute ischemic stroke (AIS). Methods All AIS cases in which Penumbra RED aspiration catheters (RED 62, 68, or 72) were utilized as a frontline treatment were included in the analysis. Retrieved clot fragments were classified based on their gross appearance. Key time metrics and procedural data were also collected, including first‐pass / post‐procedure modified Treatment in Cerebral Ischemia (mTICI) score. Results Of 400 patients enrolled across 25 US centers, 161 underwent thrombectomy with Penumbra RED catheters over ten months (Jul 2021 through Apr 2022). The mean patient age was 70.7 years, and 50.9% were female. The middle cerebral artery first segment (M1) was the most common primary occlusion site (60.4%; 96/159). IV t‐PA was administered before the procedure in 13.7% (22/161) of patients. The median time from stroke onset / last known well to mTICI≥ 2b was 5.0 hrs. [IQR 3‐11], and the median time from a puncture to mTICI≥ 2b was 23.0 mins [IQR 15‐31]. Firm‐red clots represented 45.3% (67/148), while soft‐red clots were found in 37.8% (56/148) of retrieved clots. In turn, firm‐white and soft‐white clots were seen in 11.5% (17/148) and 5.4% (8/148) of cases, respectively. Rates of the first pass and final mTICI≥ 2b scores by clot type are shown in Table 1. Conclusions Aspiration thrombectomy with Penumbra RED catheters resulted in good revascularization rates for all clot types.
Data-Retention Characteristics Comparison of 2D and 3D TLC NAND Flash Memories (2017)

Data-retention characteristics of 3-dimensional (3D) NAND flash memory have been evaluated with the optimal Vref (read reference voltage) shift in comparison with 2-dimentional (2D) (1Xnm) NAND flash memory. Bit-error rate (BER) of data-retention and write/erase (W/E) cycling in 3D NAND flash are much smaller than that in 2D NAND flash. Also, in 3D NAND flash, BER of Bottom Word-line is 1.9-times higher than Top Word-line, due to wider Vth distribution width. The data-retention lifetime of 3D NAND flash is estimated to about 10 years at 85degC, W/E=1~300 cycles by the Vth distribution margin evaluation without considering the inter-block, inter-wafer and inter-lot variations and process/voltage/temperature (PVT) variations of the read reference voltage circuit. On the other hand, the data-retention lifetime of 2D NAND flash is estimated 1000 years in W/E=1 and is rapidly degraded to 1 year in W/E=300. Therefore, 3D NAND flash is suitable to apply to Cold Flash with a few hundred times update and data center SSD with many times update. 2D NAND flash is suitable for digital archive: millennium memory with only one time write.
Crash Testing and Evaluation of the Florida/Jersey Safety-Shaped Bridge Rail (2007)

The Florida Department of Transportation (FDOT) uses the Jersey safety-shaped barrier extensively on highways today. A number of the designs from prior years have minimal reinforcement and when the current design procedure is used to evaluate the respective designs, the analysis indicates marginal performance may be anticipated when impacted by an errant vehicle. Therefore, FDOT elected to perform a full-scale crash test of the most critical design deployed in the field. This paper describes the background, objectives, study approach, and results of this FDOT research project, which ultimately demonstrated that the Florida bridge rail contained and redirected the single-unit truck used in the crash test. The truck did not penetrate, underride, or override the installation. Minimal movement of the bridge was noted during the test with no permanent deformation.
Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution (2013)

During mouse skeletal muscle development, the Nfix gene has a pivotal role in regulating fetal-specific transcription. Zebrafish and mice share related programs for muscle development, although zebrafish develops at a much faster rate. In fact, although mouse fetal muscle fibers form after 15 days of development, in fish secondary muscle fibers form by 48 hours post-fertilization in a process that until now has been poorly characterized mechanically. In this work, we studied the zebrafish ortholog Nfix (nfixa) and its role in the proper switch to the secondary myogenic wave. This allowed us to highlight evolutionarily conserved and divergent functions of Nfix. In fact, the knock down of nfixa in zebrafish blocks secondary myogenesis, as in mouse, but also alters primary slow muscle fiber formation. Moreover, whereas Nfix mutant mice are motile, nfixa knockdown zebrafish display impaired motility that probably depends upon disruption of the sarcoplasmic reticulum. We conclude that, during vertebrate evolution, the transcription factor Nfix lost some specific functions, probably as a consequence of the different environment in which teleosts and mammals develop.
Mechanism of polyoxometalate-mediated inactivation of DNA polymerases: an analysis with HIV-1 reverse transcriptase indicates specificity for the DNA-binding cleft (1996)

The anti-DNA polymerase activity of a structural family of polyoxometalates has been determined. Two representative compounds of this family, possessing a saddle-like structure [(O3POPO3)4W12O36]16- (polyoxometalate I) and [(O3PCH2PO3)4W12O36]16- (polyoxometalate II) were found to inhibit all the DNA polymerases tested, with IC50 values ranging from 2 to 10 microM. A comparative study with HIV-1 reverse transcriptase (RT) and Klenow polymerase as representative DNA polymerases indicated that protection from inactivation was achieved by inclusion of DNA but not by deoxynucleotide triphosphates (dNTPs). Kinetic analysis revealed that the mode of HIV-1 RT inhibition is competitive with respect to DNA, and non-competitive with respect to dNTP binding. Cross-linking experiments confirmed that the inhibitors interfere with the DNA-binding function of HIV-1 reverse transcriptase. Interestingly, a number of drug-resistant mutants of HIV-1 RT exhibit a sensitivity to polyoxometalate comparable to the wild-type HIV-1 RT, suggesting that these polyoxometalates interact at a novel site. Because different polymerases contain DNA-binding clefts of various dimensions, it should be possible to modify polyoxometalates or to add a link to an enzyme-specific drug so that more effective inhibitors could be developed. Using a computer model of HIV-1 RT we performed docking studies in a binary complex (enzyme-polyoxometalate I) to propose tentatively a possible interacting site in HIV-1 RT consistent with the available biochemical results as well as with the geometric and charge constraints of the two molecules.
Treatment for bilateral diaphragmatic dysfunction using phrenic nerve reconstruction and diaphragm pacemakers (2020)

PR and simultaneous implantation of a DP may restore functional activity and alleviate symptoms in patients with bilateral diaphragmatic dysfunction. PR plus diaphragm pacing appear to result in greater functional muscle recovery than pacing alone.
Tumor Infiltrating Lymphocytes in Multi-National Cohorts of Ductal Carcinoma In Situ (DCIS) of Breast (2022)

Tumor-infiltrating lymphocytes (TILs) are prognostic in invasive breast cancer. However, their prognostic significance in ductal carcinoma in situ (DCIS) has been controversial. To investigate the prognostic role of TILs in DCIS outcome, we used different scoring methods for TILs in multi-national cohorts from Asian and European women. Self-described race was genetically confirmed using QC Infinium array combined with radmixture software. Stromal TILs, touching TILs, circumferential TILs, and hotspots were quantified on H&E-stained slides and correlated with the development of second breast cancer events (BCE) and other clinico-pathological variables. In univariate survival analysis, age older than 50 years, hormone receptor positivity and the presence of circumferential TILs were weakly associated with the absence of BCE at the 5-year follow-up in all cohorts (p < 0.03; p < 0.02; and p < 0.02, respectively, adjusted p = 0.11). In the multivariable analysis, circumferential TILs were an independent predictor of a better outcome (Wald test p = 0.01), whereas younger age was associated with BCE. Asian patients were younger with larger, higher grade, HR negative DCIS lesions, and higher TIL variables. The spatial arrangement of TILs may serve as a better prognostic indicator in DCIS cases than stromal TILs alone and may be added in guidelines for TILs evaluation in DCIS.
Asymmetric Total Synthesis of Rollicosin. (2005)

The first total synthesis of rollicosin, a member of a rare subgroup of Annonaceous acetogenins containing two terminal γ-lactones, is\nreported. The approach features a highly regio- and stereoselective tandem ring-closing/cross-metathesis reaction for construction of the\neast-wing lactone and incorporation of the alkyl spacer. Establishment of the C4 stereocenter and addition of the west-wing lactone were\nachieved by Sharpless asymmetric dihydroxylation and enolate alkylation.
Using embedded wired and wireless seismic networks in the moment-resisting steel frame Factor building for damage identification (2006)

Abstract: Ideally both spectral and time domain data could be used to compute the total building response and to make predictions of damage patterns based on various input scenarios. The combination of frequency change information coupled with that provided by wavefield properties can pinpoint the time and location of damage more accurately, especially for densely instrumented structures such as the 17-story UCLA Factor building. The 72-sensor embedded seismic array in the Factor building, recording continuous waveforms at 500 Hz, makes it possible to observe subtle changes in dynamic characteristics between pairs of floors and to relate the measurements to system properties such as changes in stiffness due to a column failure. The high dynamic range of the 24-bit digitizers allows both strong motions and ambient vibrations to be recorded with reasonable signal-to-noise ratios. Temporary decreases in frequencies of Factor building modes of vibration have been correlated with moderate-to-strong shaking, and spectral amplitudes of ambient vibrations have clear daily and weekly patterns that correlate with working hours, wind speeds, and non-seismic vibrations. Waveform data from the Factor array are also being used in comparison with finite element calculations for predictive damage behavior. A three-dimensional model of the Factor building has been developed based on structural drawings. Observed displacements for 20 small and moderate, local and regional earthquakes were
Spark Plasma Synthesis/Sintering of Dense Ceramic, Intermetallic and Composite Materials (2006)

Spark Plasma Sintering (SPS) represents a very attractive technique for the obtainment of dense materials including nanostructured ones. SPS basically consists in the simultaneous application of a pulsed DC current and an uniaxial mechanical load through a powder compact. Other than providing rapid Joule heating and likely enhancing mass transport through electromigration, the imposed pulsed high current is also reported to generate a plasma within the voids surrounding the powder particles, thus facilitating the removal of oxides surface layers that may hinder the sintering process. Selected results obtained through SPS in our laboratory for the preparation of a wide variety of materials, i.e. TiC-TiB2, MgB2, and NbAl3, will be presented in this work. Specifically, all the chosen examples are related to the use of the SPS technique for obtaining the desired material by simultaneously performing synthesis and consolidation stages in one-step.
ChemInform Abstract: Sequential Diastereoselective Addition and Allylic Azide Isomerization of syn‐ and anti‐α‐Azido‐β‐(dimethylphenylsilyl)‐E‐hex‐4‐ enoates with Acetals: Asymmetric Synthesis of γ‐Hydroxy‐α‐ amino Acid Synthons. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Development of a Multi-Step Synthesis and Workup Sequence for an Integrated, Continuous Manufacturing Process of a Pharmaceutical (2014)

The development and operation of the synthesis and workup steps of a fully integrated, continuous manufacturing plant for synthesizing aliskiren, a small molecule pharmaceutical, are presented. The plant started with advanced intermediates, two synthetic steps away from the final active pharmaceutical ingredient, and ended with finished tablets. The entire process was run on several occasions, with the data presented herein corresponding to a 240 h run at a nominal throughput of 41 g h–1 of aliskiren. The first reaction was performed solvent-free in a molten condition at a high temperature, achieving high yields (90%) and avoiding solid handling and a long residence time (due to higher concentrations compared to dilute conditions when run at lower temperatures in a solvent). The resulting stream was worked-up inline using liquid–liquid extraction with membrane-based separators that were scaled-up from microfluidic designs. The second reaction involved a Boc deprotection, using aqueous HCl that was rapidly quenched with aqueous NaOH using an inline pH measurement to control NaOH addition. The reaction maintained high yields (90–95%) under closed-loop control despite process disturbances.
Dispersion-shifted and dispersion-flattened single-mode designs (1986)

Over the last few years, advances in fiber-optic technology have allowed the introduction and rapid commercialization of single-mode systems in long-haul applications. Most if not all of this growth has been in single-mode systems operating in the 1300-nm window. But the technology and applications continue to advance toward systems with higher bit rate and longer repeater spacings. In addition, trends toward using single-mode fibers in feeder and possibly even in local distribution applications seem to be evolving. To address these needs, active research and development are going on in all aspects of the fiber-optic technology including the advanced single-mode designs. A number of groups in the U.S.A. and abroad have been working on a number of these single-mode designs including silica-core,1 dispersion-shifted,2–5 and dispersion-flattened6–9 fibers. A framework for classifying and comparing the various designs will be given. Based on this, a review of these designs for telecommunications will be presented.
Machine Learning Based IoT Edge Node Security Attack and Countermeasures (2019)

Advances in technology have enabled tremendous progress in the development of a highly connected ecosystem of ubiquitous computing devices collectively called the Internet of Things (IoT). Ensuring the security of IoT devices is a high priority due to the sensitive nature of the collected data. Physically Unclonable Functions (PUFs) have emerged as critical hardware primitive for ensuring the security of IoT nodes. Malicious modeling of PUF architectures has proven to be difficult due to the inherently stochastic nature of PUF architectures. Extant approaches to malicious PUF modeling assume that a priori knowledge and physical access to the PUF architecture is available for malicious attack on the IoT node. However, many IoT networks make the underlying assumption that the PUF architecture is sufficiently tamper-proof, both physically and mathematically. In this work, we show that knowledge of the underlying PUF structure is not necessary to clone a PUF. We present a novel non-invasive, architecture independent, machine learning attack for strong PUF designs with a cloning accuracy of 93.5% and improvements of up to 48.31% over an alternative, two-stage brute force attack model. We also propose a machine-learning based countermeasure, discriminator, which can distinguish cloned PUF devices and authentic PUFs with an average accuracy of 96.01%. The proposed discriminator can be used for rapidly authenticating millions of IoT nodes remotely from the cloud server.
THE SMART CANNULA (2002)

During percutaneous cannulation, the diameter of the venous cannula is determined by the size of the access site. To limit this restriction, the Smart cannula has been developed. Its design allows self-expansion within the recipient vein. While such design provides improved flow, its impact on blood elements needs to be assessed. Twelve calves were connected to a standard CPB circuit by jugular and carotid cannulation, for 6h and with a flow of 5L/min. The venous drainage was achieved either with a Smart cannula (group 1, n = b) or a standard single stage 32Fr cannula (group 2, n = 6). Blood samples were taken at regular interval for hematological and hemolytic parameters. Results of both groups were compared with ANOVA test. Red blood cell count, corrected for hematocrit and normalized by pre-bypass value, remained stable in both groups (P=0.14): at bh, 98±2.3% in group 1 and 99±1.9% in group 2. Free hemoglobin profiles were similar (P=0.6), while no single value exceeded 14mg/dL. LDH profiles were stable in both groups (P=0.74). Thrombocyte count, corrected for hematocrit and normalized by pre-bypass value, exhibited similar profiles too (P=0.79): at 6h, 72.7±13% in group 1 and 66.6±9% in group 2. The Smart cannula, with its innovative design for improved drainage, has no impact on blood cells integrity when compared with standard single stage cannula in this model of prolonged perfusion.