gebhart/patrepeval huggingface dataset:
Proteomic and phosphoproteomic profiling of shammah induced signaling in oral keratinocytes (2021)

Shammah is a smokeless tobacco product often mixed with lime, ash, black pepper and flavorings. Exposure to shammah has been linked with dental diseases and oral squamous cell carcinoma. There is limited literature on the prevalence of shammah and its role in pathobiology of oral cancer. In this study, we developed a cellular model to understand the effect of chronic shammah exposure on oral keratinocytes. Chronic exposure to shammah resulted in increased proliferation and invasiveness of non-transformed oral keratinocytes. Quantitative proteomics of shammah treated cells compared to untreated cells led to quantification of 4712 proteins of which 402 were found to be significantly altered. In addition, phosphoproteomics analysis of shammah treated cells compared to untreated revealed hyperphosphorylation of 36 proteins and hypophosphorylation of 83 proteins (twofold, p-value ≤ 0.05). Bioinformatics analysis of significantly altered proteins showed enrichment of proteins involved in extracellular matrix interactions, necroptosis and peroxisome mediated fatty acid oxidation. Kinase-Substrate Enrichment Analysis showed significant increase in activity of kinases such as ROCK1, RAF1, PRKCE and HIPK2 in shammah treated cells. These results provide better understanding of how shammah transforms non-neoplastic cells and warrants additional studies that may assist in improved early diagnosis and treatment of shammah induced oral cancer.
Lattice quantum codes and exotic topological phases of matter (2013)

This thesis addresses whether it is possible to build a robust memory device for quantum information. Many schemes for fault-tolerant quantum information processing have been developed so far, one of which, called topological quantum computation, makes use of degrees of freedom that are inherently insensitive to local errors. However, this scheme is not so reliable against thermal errors. Other fault-tolerant schemes achieve better reliability through active error correction, but incur a substantial overhead cost. Thus, it is of practical importance and theoretical interest to design and assess fault-tolerant schemes that work well at finite temperature without active error correction. In this thesis, a three-dimensional gapped lattice spin model is found which demonstrates for the first time that a reliable quantum memory at finite temperature is possible, at least to some extent. When quantum information is encoded into a highly entangled ground state of this model and subjected to thermal errors, the errors remain easily correctable for a long time without any active intervention, because a macroscopic energy barrier keeps the errors well localized. As a result, stored quantum information can be retrieved faithfully for a memory time which grows exponentially with the square of the inverse temperature. In contrast, for previously known types of topological quantum storage in three or fewer spatial dimensions the memory time scales exponentially with the inverse temperature, rather than its square. This spin model exhibits a previously unexpected topological quantum order, in which ground states are locally indistinguishable, pointlike excitations are immobile, and the immobility is not affected by small perturbations of the Hamiltonian. The degeneracy of the ground state, though also insensitive to perturbations, is a complicated number-theoretic function of the system size, and the system bifurcates into multiple noninteracting copies of itself under real-space renormalization group transformations. The degeneracy, the excitations, and the renormalization group flow can be analyzed using a framework that exploits the spin model's symmetry and some associated free resolutions of modules over polynomial algebras.
Appendix C Noise Correlation Matrix (2016)

Describes the use of the Real Frequency Technique for designing and realizing RF/microwave amplifiers and circuits This book focuses on the authors' Real Frequency Technique (RFT) and its application to a wide variety of multi-stage microwave amplifiers and active filters, and passive equalizers for radar pulse shaping and antenna return loss applications. The first two chapters review the fundamentals of microwave amplifier design and provide a description of the RFT. Each subsequent chapter introduces a new type of amplifier or circuit design, reviews its design problems, and explains how the RFT can be adapted to solve these problems. The authors take a practical approach by summarizing the design steps and giving numerous examples of amplifier realizations and measured responses. Provides a complete description of the RFT as it is first used to design multistage lumped amplifiers using a progressive optimization of the equalizers, leading to a small umber of parameters to optimize simultaneously Presents modifications to the RFT to design trans-impedance microwave amplifiers that are used for photodiodes acting as high impedance current sources Discusses the methods using the RFT to optimize equalizers made of lossy distributed networks Covers methods and examples for designing standard linear multi-stage power amplifiers and those using arborescent structures Describes how to use the RFT to design multi?]stage active filters Shows the flexibility of the RFT to solve a variety of microwave circuit design problems like the problem of passive equalizer design for Radar receivers Examines a possible method for the synthesis of microwave antennas using the RFT Microwave Amplifier and Active Circuit Design Using the Real Frequency Technique is intended for researchers and RF and microwave engineers but is also suitable for advanced graduate students in circuit esign. Dr. Beneat and Dr. Jarry are members of the editorial board of Wiley’s International Journal of RF and Microwave Computer Aided Engineering . They have published seven books together, including Advanced Design Techniques and Realizations of Microwave and RF Filters (Wiley-IEEE 2008), Design and Realizations of Miniaturized Fractals RF and Microwave Filters (Wiley 2009), Miniaturized Microwave Fractal Filters—M2F2 (Wiley 2012),  and RF and Microwave Electromagnetism (Wiley-ISTE 2014).
Abiotic stresses, plant reactions and new approaches towards understanding stress tolerance. (2001)

Three broad categories of physiological responses to environmental stress factors are discussed: (i) the immediate (or 'downstream') reactions; (ii) stress sensing and signalling leading to adjustments for a new equilibrium; and (iii) long-term developmental changes.
Extrusion Induced Morphologies and Properties of Layered Block Copolymer/Polystyrene Mixtures (2010)

Abstract Using transmission electron microscopy (TEM) and tensile testing, we investigated the morphology and the micro‐deformation processes in a new kind of highly asymmetric polystyrene/polybutadiene based triblock copolymer and its blends with general purpose polystyrene (GPPS). The emphasis has been put on the analysis of blends morphology evolved under extrusion conditions and the impact of the later on the micromechanical behaviour of the blends. It was found that the phase separated structures were strongly oriented along the extrusion direction leading to the anisotropic mechanical behaviour. The blends showed more ductile performance and lesser strength on loading the sample perpendicular to the extrusion direction. The ductile to brittle transition was observed when the morphology of the blends was dominated by the glassy phase for 60 wt.‐% GPPS.
Converse flexoelectric coefficient f1212 in bulk Ba0.67Sr0.33TiO3 (2014)

Enhanced flexoelectricity in perovskite ceramics and single crystals has been reported before. In this letter, 3-3 ceramic-ceramic Ba0.6Sr0.4TiO3/Ni0.8Zn0.2Fe2O4 composite with a colossal permittivity was employed in the conventional pure bending experiment in order to examine the transverse flexoelectric response. The measured flexoelectric coefficient at 30 Hz is 128 μC/m and varies to 16 μC/m with the frequency increasing from 30 Hz to 120 Hz, mainly due to the inverse correlation between the permittivity and the frequency. This result reveals the permittivity dependence of flexoelectric coefficient in the frequency dispersion materials, suggesting that the giant permittivity composites can be good flexoelectric materials.
Evaluating the Cost-Effectiveness of Roadside Culvert Treatments (2011)

Roadside cross-drainage culverts have been found to affect vehicle accident injury levels. As a result, highway designers have commonly used three safety treatments to protect errant motorists from striking culvert openings. These safety treatments have included: culvert extension, guardrail installation, and the application of safety grating. However, the identification of the most appropriate safety treatment for roadside culverts may be challenging; accident costs may dramatically change under different road and traffic characteristics. The purpose of this study was to estimate accident costs for a wide range of road and traffic scenarios and then define the safest treatment (i.e., treatment with lowest accident cost) for a variety of traffic, roadway, and roadside characteristics. Over 3,000 highway scenarios were modeled using the Roadside Safety Analysis Program (RSAP). This study showed that the selection of culvert safety treatments should be flexible when considering different road and traffic characteristics. The findings demonstrated that culvert extension and grating were found to produce the lowest accident costs for all highway scenarios that were modeled, and guardrail protection was not recommended for any of the scenarios. Therefore, it is believed that the expanded adoption of culvert extension and culvert grates can improve overall highway safety.
The DHSS Mental Illness Policy Paper: A Personal View (1983)

In November 1982, a conference on the provision of comprehensive, district based, psychiatric services was organized by the Community Psychiatry Research Unit of St Bartholomew's Hospital Medical College. At this conference, Lord Trefgarne, Parliamentary Under Secretary of State at the DHSS, reaffirmed the Department's policy of creating local district psychiatric services and closing those mental illness hospitals which are not well placed to provide a local service.
High average power diode-end-pumped intracavity-doubled Nd:YAG laser (1998)

A compact diode-end-pumped Nd:YAG laser was frequency-doubled to 0.532 μm with an intracavity KTP or LBO crystal using a “V” cavity configuration. Two acousto-optic Q-switches were employed at repetition rates of 10–30 kHz. Dichroic fold and end mirrors were used to output two beams with up to 140 W of 0.532 μm power using KTP and 116 W using LBO as the frequency doubling crystal. The maximum output power at 0.532 μm corresponds to 66% of the 1.064 μm power obtained with an optimized output coupler reflectivity. The minimum output pulse duration varied with repetition rate from 90 to 130 ns. The multimode output beam had a smooth profile and a beam quality of M2 = 51.
Dynamic Modeling of Partial Liquid Lift for Stripper Gas Wells (2006)

This paper presents the results of a dynamic modeling approach for prediction of the critical rate to unload stripper gas wells. Methodologies in the literature such as the ones by Turner et al1and Coleman et al2 predict critical gas rates by using force balances based on bulk properties of the liquid and gas column. Using a one-dimensional modeling of two phase flow in a vertical column, we are able to incorporate the phase behavioral effects caused by temperature and pressure changes affecting fluid density and localized conditions of liquid droplets demonstrating a more accurate way to predict critical gas rates.The dynamic prediction model allows incorporation of the formation depth and pressure, temperature gradients and tubing size. Gas composition ranges from dry gas to rich gas with potential for condensate formation. The model allows mapping and tracking the phase behavior conditions after flow stoppage under the condition of low gas rate and predicts the energy requirement to partially lighten the liquid column and resuming gas flow.
fib Bulletin 14. Externally bonded FRP reinforcement for RC structures (2001)

Externally bonded FRP reinforcement for RC structures (PDF) <i>fib</i> Bulletins N° 14. Externally bonded FRP reinforcement for RC structures. Technical report (138 pages, ISBN 978-2-88394-054-3, October 2001) - PDF format
The Detection of Cocaine in Hair Specimens Using Micro-Plate Enzyme Immunoassay (1999)

The analysis of hair for drugs of abuse is becoming increasingly popular and is under consideration by the Division of Health and Human Services as a possible alternative or adjunct to urinalysis in workplace programs. The detection of cocaine in human hair using a commercially available micro-plate enzyme immunoassay is described for the first time. Sample size and incubation time were the major variables in the optimization of the method. In order to validate the procedure, the method was applied to 105 consecutive hair samples routinely received into our laboratory. The samples were simultaneously analyzed by the Micro-Plate immunoassay (EIA), as well as our current fluorescence polarization immunoassay (FPIA) procedure and gas chromatography-mass spectrometry (GC/MS). The sensitivity of the EIA and FPIA assays were 75% and 67.8% respectively; specificity 97.4% and 80.5% respectively; and efficiency 91.4 and 77.1% respectively. The Micro-Plate EIA was shown to be a valid alternative to other immunoassay screening methods for the detection of cocaine in hair by demonstrating increased sensitivity, specificity and efficiency over our current technique.
<title>Functional monitoring of tissues using frequency-domain laser light scattering</title> (1994)

Determination of the optical parameters of tissues is a necessary element of laser medical diagnostics and therapy planning. In this work a mathematical model of the photon migration in tissues is considered in the assumption of the harmonic modulation of the incident laser light. The scattering coefficient and the photon's life time in virtually absorbed state can be calculated from the modulation coefficient and phase shift between incident and scattered light. Frequency-domain measurements were performed using two laser diodes (wavelengths 805 and 850 nm) as light-modulated sources and fiber-optic light guides for delivering the light to tissues surface and collecting the back scattering output. It is shown that measured difference in phase shift of scattered light intensity is proportional to difference in mean pathlength of photons at two wavelengths.
Tunable slow light device using quantum dot semiconductor laser (2006)

This investigation experimentally demonstrates a tunable slow light device using a quantum dot (QD) semiconductor laser. The QD semiconductor laser at 1.3 mum fabricated on a GaAs substrate is grown by molecular beam epitaxy. Tunable slow light can be achieved by adjusting the bias current and wavelength detuning. The slow light device operated under probe signal from 5 to 10 GHz is presented. Moreover, we also demonstrate that the tunable slow light device can be used in a subcarrier multiplexed system.
OnTheMark: Integrated Stochastic Resource Planning of Human Capital Supply Chains (2011)

In this paper, we present a suite of innovative operations research models and methods called OnTheMark (OTM). This suite supports the effective management of human capital supply chains by addressing distinct features of human talent that cannot be handled via traditional supply chain management. OTM consists of novel solutions for (1) statistical forecasting of demand and human capital requirements, (2) risk-based stochastic human-talent capacity planning, (3) stochastic modeling and optimization (control) of human capital supply evolutionary dynamics over time, (4) optimal multiskill supply-demand matching, and (5) stochastic optimization of business decisions and investments to manage human capital shortages and overages. The OTM suite was developed and deployed as an important part of the human capital management and planning process within IBM, providing support for decision making to drive better business performance. This is achieved through important contributions in the areas of stochastic models and optimization (control), and the innovative application and integration of these models and methods in human capital management applications.
Growth of very large InN microcrystals by molecular beam epitaxy using epitaxial lateral overgrowth (2015)

Very thick InN (∼40 μm) was grown by molecular beam epitaxy using the epitaxial lateral overgrowth (ELO) technique. In some regions, the ELO of InN was observed as expected, indicating an important step toward fabricating quasi-bulk InN substrates. Interestingly, most parts of the sample consist of large flat-topped microcrystals and well-faceted microstructures. This is likely due to local growth condition variations during ELO, which is supported by an experiment where ELO of InN was performed on a substrate with various stripe mask patterns. TEM characterization of a flat top InN microcrystal revealed few stacking faults and only related threading dislocations. Defect-free small faceted microcrystals were also observed. The thick InN crystals show a narrow photoluminescence spectrum with a peak at 0.679 eV and linewidth of 16.8 meV at 4 K.
High-fidelity Quantum Logic Gates with Interacting Bosons on a 1D Lattice (2015)

We present a scheme for implementing high-fidelity quantum logic gates using the quantum walk of a few interacting bosons on a one-dimensional lattice. The gate operation is carried out by a single compact lattice described by a one-dimensional Bose-Hubbard model with only nearest-neighbor hopping and on-site interactions. We find high-fidelity deterministic logic operations for a gate set (including the CNOT gate) that is universal for quantum information processing. We discuss the applicability of this scheme in light of recent developments in controlling and monitoring cold-atoms in optical lattices, as well as an implementation with realistic nonlinear quantum photonic devices.
A Semi-Autonomic Bytecode Repair Framework (2019)

The Semi-Autonomic Bytecode Repair Engine (SABRE) is a toolchain for Java Virtual Machine languages that identifies and repairs certain classes of problematic conditions that emerge over time. We describe the utility of SABRE in the context of a case study.
Unexpected Analyte Oxidation during Desorption Electrospray Ionization-Mass Spectrometry (2008)

During the analysis of surface-spotted analytes using desorption electrospray ionization-mass spectrometry (DESI-MS), abundant ions are sometimes observed that appear to be the result of oxygen addition reactions. In this investigation, the effect of sample aging, the ambient lab environment, spray voltage, analyte surface concentration, and surface type on this oxidative modification of spotted analytes, exemplified by tamoxifen and reserpine, during analysis by DESI-MS was studied. Simple exposure of the samples to air and to ambient lighting increased the extent of oxidation. Increased spray voltage also led to increased analyte oxidation, possibly as a result of oxidative species formed electrochemically at the emitter electrode or in the gas phase by discharge processes. These oxidative species are carried by the spray and impinge on and react with the sampled analyte during desorption/ionization. The relative abundance of oxidized species was more significant for the analysis of deposited analyte having a relatively low surface concentration. Increasing the spray solvent flow rate and the addition of hydroquinone as a redox buffer to the spray solvent were found to decrease, but not entirely eliminate, analyte oxidation during analysis. The major parameters that both minimize and maximize analyte oxidation were identified, and DESI-MS operational recommendations to avoid these unwanted reactions are suggested.
Some results on risk-sensitive control with partial information (2002)

We consider in this presentation the risk-sensitive control problem with partial observation. Risk-sensitive Zakai and Kushner equations are established and studied. They are explicitly solved in all situations where the classical Zakai and Kushner equations can be solved. In these cases the solution of the control problem can be characterized nicely. Also, the small noise case is considered. The limit problem is a differential game with output control. The full justification of all the results is still a long range plan.
Circular Waveguide Grating-Via-Grating for Interlayer Coupling (2017)

A circular waveguide grating-via-grating (GVG) coupler is designed to achieve vertical interlayer optical coupling. Interlayer coupling efficiency is simulated to be 41% (single layer efficiency is 64%) for Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> circular waveguide gratings for TE polarization at 1.55-μm wavelength, which is comparable with that of rectangular SOI gratings incorporating adjacentlayer reflectors. The grating ridges of circular gratings are relatively wide (e.g. >465 nm) and adjacent-layer reflectors are not required, both of which simplify fabrication. In-plane circular distributed Bragg reflectors are incorporated to enhance the waveguide-grating interaction. The resonance-enhanced circular gratings are relatively compact compared with the conventional Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> -based rectangular gratings, e.g., the inner grating is 20 μm in diameter. Furthermore, this GVG coupling structure is less sensitive to misalignment, works well for a wide range of wavelengths (e.g. ±100 nm), and can operate with larger interlayer separations (e.g. ~5 μm) compared with conventional rectangular gratings.
Maximizing the Benefit of Life-Saving Treatments for Pompe Disease, Spinal Muscular Atrophy, and Duchenne Muscular Dystrophy Through Newborn Screening (2019)

The availability of advanced screening methods, the emergence of effective treatment, and the support of professional organizations may facilitate the expansion of NBS, such that an increasing number of infants can be identified in the newborn period who will benefit from life-saving interventions.
Purification of TNF Binding Proteins (2004)

The finding that the two tumor necrosis factor receptors (TNFR) exist in soluble form in various body fluids not only has substantiated the paradigm of naturally existing soluble cytokine receptors but also has represented a milestone on the road to the biochemical and biological characterization of the two TNFRs. This chapter gives a simple, basic protocol for the purification of the two soluble TNFRs. The protocols found here may be easily adapted for the purification of various other soluble cytokine receptors. The purified proteins may be used in biological experiments or for the generation of specific research tools such as polyclonal or monoclonal antibodies.
Safepaths: Vaccine Diary Protocol and Decentralized Vaccine Coordination System using a Privacy Preserving User Centric Experience (2021)

In this early draft, we present an end-to-end decentralized protocol for the secure and privacy preserving workflow of vaccination, vaccination status verification, and adverse reactions or symptoms reporting. The proposed system improves the efficiency, privacy, equity, and effectiveness of the existing manual system while remaining interoperable with its capabilities. We also discuss various security concerns and alternate methodologies based on the proposed protocols.