gebhart/patrepeval huggingface dataset:
Video Codec Using Flexible Block Partitioning and Advanced Prediction, Transform and Loop Filtering Technologies (2020)

This paper describes a joint response to the Call for Proposals by Samsung, Huawei, GoPro, and HiSilicon on Video Compression with Capability beyond HEVC/H.265, jointly issued by ITU-T SG16 Q.6 (VCEG) and ISO/IEC JTC1/SC29/WG11 (MPEG). In the proposed codec, the coding framework supports hierarchical splitting with binary and ternary trees and flexible coding order representations. Additionally, novel compression tools on inter/intra prediction, in-loop filtering, and entropy coding have been proposed. The proposed compression scheme provides significantly higher compression capability than the state-of-the-art HEVC/H.265 standard for SDR (Standard Dynamic Range) category while maintaining complexity acceptable for emerging applications. When all the proposed algorithmic tools are used, the proposed video codec achieves approximately 40% bit-saving for the SDR cetegory on average compared to HEVC/H.265 anchor.
Comparative Study of 1,5-Dinitrogen Schiff Bases as Potential Ligands in Palladium-Catalyzed Allylic Alkylation (2003)

1-(2'-Pyrido and 2'-quinolino)-(1R)-arylethylamino)-ethylidenes (7-12) were prepared as potential ligands in Pd II catalytic complexes for enantioselective allylic alkylation of 1,3-diphenyl-1-acetoxy-propene-2 (15).Alkylation with palladium complexes of 7-12 yielded 1,3-diphenyl-1-dimethylmalonyl-propene-2 ( 14) with enantioselectivity up to 55 % e.e.Enantioselectivity is discussed in view of the results recently reported for structurally related 1,5-bidentate dinitrogen ligands of C 1 symmetry.Reversal of enantioselectivity observed for the ligands 10 and 11 is attributed to the inversion of steric requirements in the second coordination sphere of their catalytic complexes.
Garlic (2002)

In a large modern enterprise, information is almost inevitably distributed among several database management systems. Despite considerable attention from the research community, relatively few commercial systems have attempted to address this issue. This paper describes new technology that enables clients of IBM's DB2 Universal Database to access the data and specialized computational capabilities of a wide range of non-relational data sources. This technology, based on the Garlic prototype developed at the Almaden Research Center, complements and extends DB2's existing ability to federate relational data sources.The paper focuses on three topics. Firstly, we show how the DB2 catalogs are used as an extensible repository for the metadata needed to access remotely-stored information. Secondly, we describe how the Garlic approach to query planning, in which source-specific modules and the federated server cooperate to develop an optimized execution plan, has been realized in DB2. Lastly, we describe how DB2's query execution engine has been extended to support queries and functions that are evaluated remotely.
Impedance spectroscopic detection of binding and reactions in acid-labile dielectric polymers for biosensor applications (2018)

We synthesized previously unreported copolymers with cleavable acid-labile side chains for use as electrochemical sensing layers in order to demonstrate a novel architecture for a one-step immunosensor. This one-step system is in contrast to most antigen-capture signal amplification methods that involve complicated secondary labeling techniques, or require the addition of redox probes to achieve a sensing response. A series of novel copolymers composed of various trityl-containing monomers were synthesized and characterized to determine their dielectric properties. Results indicate that the thin films of these polymers are stable in water, but some begin to degrade under acidic conditions or upon antigen binding, causing observable changes in the phase angle.
Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity (1997)

We have purified a form of protein phosphatase 1 (PP1) from HeLa cell nuclei, in which the phosphatase is complexed to a regulatory subunit termed p99. We report here the cloning and characterisation of the p99 component. p99 mRNA is widely expressed in human tissues and immunofluorescence analysis with anti-p99 antibodies showed a punctate nucleoplasmic staining with additional accumulations within the nucleolus. The C-terminus of p99 contains seven RGG RNA-binding motifs, followed by eleven decapeptide repeats containing six or more of the following conserved residues (GHRPHEGPGG), and finally a putative zinc finger domain. Recombinant p99 suppresses the phosphorylase phosphatase activity of PP1 by > 90% and the canonical PP1-binding motif on p99 (residues 396-401) is unusual in that the phenylalanine residue is replaced by tryptophan.
ChemInform Abstract: THE REACTION OF SOME PROPARGYL ALCOHOLS WITH BENZENESELENENYL CHLORIDE (1981)

Abstract Die 1:1‐molare Umsetzung der Propargylalkohole (II) und Benzolselenenylchlorid (III) führen unter stereospezifischen anti‐Additionsprozessen zu den Markownikoff‐Addukten (I) und/oder den anti‐Markownikoff‐Addukten (IV).
OP23 The efficacy and safety of guselkumab induction therapy in patients with moderately to severely active Ulcerative Colitis: Phase 2b QUASAR Study results through week 12 (2022)

Abstract Background The QUASAR Induction Study 1 (NCT04033445) is a phase 2b randomized, double-blind, placebo-controlled, dose-ranging study to evaluate the efficacy and safety of guselkumab (GUS), an interleukin-23 p19 subunit antagonist, as induction therapy in patients with moderately to severely active ulcerative colitis (UC) who had an inadequate response or intolerance to conventional (ie, thiopurines or corticosteroids) or advanced therapy (ie, tumor necrosis factor alpha antagonists, vedolizumab, or tofacitinib). Methods Patients included in these analyses had moderately to severely active UC (defined as a modified Mayo score of 5 to 9, inclusive) with a Mayo rectal bleeding subscore ≥ 1 and a Mayo endoscopy subscore ≥ 2 obtained during central review of video endoscopy at baseline. Patients were randomized 1:1:1 to receive IV GUS 200 mg, 400 mg, or placebo at Weeks 0, 4, and 8. The primary endpoint was clinical response at Week 12, and major secondary endpoints included clinical remission, symptomatic remission, endoscopic improvement, histo-endoscopic mucosal improvement, and endoscopic normalization at Week 12. Type 1 error was controlled at the 0.05 significance level for the primary endpoint; no other endpoints were controlled for multiplicity. Safety was assessed through Week 12. Results Three hundred thirteen patients were randomized in the primary analysis population (mean age, 41.6 yrs; male 59.1%, mean UC duration, 7.55 yrs; mean Mayo score, 9.2; endoscopy subscore of 3 indicating severe disease, 70%; baseline oral corticosteroid use, 39.6%). Approximately 50% had a prior inadequate response or intolerance to advanced therapy for UC. The baseline demographics and disease characteristics were generally similar among treatment groups (Table 1). At Week 12, a significantly greater proportion of patients treated with GUS 200 mg and 400 mg achieved clinical response compared with placebo (61.4% and 60.7% vs 27.6%, respectively, both p&amp;lt;0.001). A greater proportion of GUS-treated patients compared with placebo-treated patients achieved the major secondary endpoints at Week 12 (Figure 1). The proportions of patients reporting adverse events, serious adverse events, and adverse events leading to discontinuation in the GUS groups were not greater compared with placebo (Table 2). No serious infections were reported for GUS. No cases of malignancy or death were reported. Conclusion In patients with moderately to severely active UC, GUS induction treatment demonstrated superior efficacy compared with placebo treatment. Overall, safety results through Week 12 were consistent with the known safety profile of GUS in approved indications. The efficacy and safety of GUS 200 mg and 400 mg were comparable.
Powder Coatings Chemistry and Technology (2019)

The 3rd and revised edition of Powder Coatings as eBook. All about powder coatings in one book - from the current market situation and REACH to the various types of powder coatings, raw materials, parameters affecting the properties of powder coatings, production technologies and application technologies. Indispensable for everyone who comes in contact with powder coatings in their daily work.
Visible-light-driven Cr(vi) reduction by ferrocene-integrated conjugated porous polymers via dual catalytic routes (2021)

Conjugated porous polymers with rapid separation of photogenerated charges and multiple catalytic pathways remain a great challenge. Herein, two ferrocene-based polymers (Fc-CPPs) with high charge separation efficiency and unique dual catalytic routes for Cr(vi) reduction were developed. They exhibited an excellent efficiency, with almost 99% of Cr(vi) readily converted to Cr(iii) under 15 min of visible light illumination (λ > 420 nm).
ChemInform Abstract: A New and Convenient Synthesis of 3(2H)‐Pyridazinones by Reacting Carbanion of Ethyl Trimethylsilylacetate with Phenylhydrazones. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
MRI Markers of Mixed Pathology and Cognitive Impairment in Multiethnic Asians (2020)

There is a need to elucidate the combined influence of neurodegeneration and cerebrovascular disease (CeVD) on cognitive impairment, especially in diverse populations. Here, we evaluated 840 multiethnic individuals (mean age = 70.18) across the disease spectrum from the Epidemiology of Dementia in Singapore study. First, we determined whether a validated quantitative MRI score of mixed pathology is associated with clinical diagnosis and whether the score differed between ethnicities (Chinese, Malays, and Indians). We then evaluated whether the score was associated with multidomain cognitive impairment and if additional measures of CeVD were further associated with cognitive impairment. We found that lower quantitative MRI scores were associated with severity of clinical diagnosis and Chinese individuals had the highest quantitative MRI scores, followed by Indians and Malays. Lower quantitative MRI scores were also associated with lower performance in attention, language, visuoconstruction, visuomotor, visual, and verbal memory domains. Lastly, the presence of intracranial stenosis and cortical cerebral microinfarcts, but not cerebral microbleeds, were associated with memory performance beyond quantitative MRI scores. Taken together, our results demonstrate the utility of using multiple MRI markers of neurodegeneration and CeVD for identifying multiethnic Asians with the greatest cognitive impairment due to mixed pathology.
Thermal Conversion of Paper Industry Wastes and Engine Testing of Derived Pyrolysis Oils for Sustainable CHP Generation (2012)

Secondary (recycled) fibre paper mills within Europe are significant users of both heat and electricity. The cost of producing this energy is increasing year upon year. These mills are also significant producers of de¬inking sludge and reject waste material. The disposal of these waste fractions is both unsustainable and costly. The focus of this work is to utilise the waste fractions produced at secondary fibre paper mills for the on¬site production of combined heat and power (CHP) using advanced thermal conversion methods (pyrolysis and gasification). This paper summarises the most successful experimental results obtained from (i) the fixed bed downdraft gasification of blends of pre¬conditioned brown paper mill rejects with wood chips in a 10 kg/hr Imbert type gasifier, (ii) the intermediate pyrolysis of de¬inking sludge in a newly patented 20 kg/hr intermediate pyrolysis reactor and (iii) the performance, emissions and combustion characteristics of an indirect injection (IDI) multi¬cylinder CI engine fuelled with de¬inking sludge pyrolysis oil¬biodiesel blends.
Chemoresistome Mapping in Individual Breast Cancer Patients Unravels Diversity in Dynamic Transcriptional Adaptation (2023)

Abstract Emerging evidence reinforce the role of non-genetic adaptive resistance to chemotherapy, that involves rewiring of transcriptional programs in surviving tumors. We combined longitudinal transcriptomics with temporal pattern analysis to dissect patient-specific emergence of resistance in breast cancer. Matched triplets of tumor biopsies (pre-treatment, post-treatment and adjacent normal) were collected from breast cancer patients who received neo-adjuvant chemotherapy. Full transcriptome was analyzed by longitudinal pattern classification to follow patient-specific expression modulations. We found that dynamics of gene expression dictates resistance-related modulations. The results unraveled important principles in emergence of adaptive resistance: 1. Genes with resistance patterns are already dysregulated in the primary tumor, supporting a primed drug-tolerant state. 2. In each patient, multiple resistance-related genes are rewired but converge into few dysregulated modules. 3. Rewiring of diverse genes and pathway dysregulation vary among individuals who receive the same treatments. Patient-specific chemoresistome maps disclosed tumors’ acquired resistance and exposed their vulnerabilities. Mapping the complexity of dysregulated pathways in individual patients revealed important insights on adaptive resistance mechanisms. To survive the toxic drug effect, tumor cells either sustain a drug-tolerant state or intensify it, specifically bypassing the drug’s interference. Depicting an individual road map to resistance can offer personalized therapeutic strategies.
Relevance of TSH Receptor Stimulating and Blocking Autoantibody Measurement for the Prediction of Relapse in Graves’ Disease (2005)

Recently, we demonstrated that higher levels of autoantibodies to the human TSH receptor (TBII) predict relapse of hyperthyroidism in Graves' disease (GD). The aim of this study was to extend this outcome prediction by dividing TBII into stimulating (TSAb) and blocking (TBAb) TSH receptor autoantibodies. Altogether, ninety patients (81 female, 9 male) were retrospectively analyzed; sixty-four patients (71 %) did not go into remission or relapsed, whereas twenty-six patients (29 %) went into remission (median follow-up: 17.5 months). TSAb and TBAb measurement was performed in a CHO cell bioassay with cAMP readout at the time of their first visit in our outpatient clinic (single point measurement in median 6.5 months after initial diagnosis). In the remission group, eighteen of twenty-six patients (69 %) were TSAb-positive, whereas fifty-three of sixty-four patients (83 %) were TSAb-positive in the relapse group (p = ns). The mean stimulation indices (SI) were 4.1 in the remission group and 12.9 in the relapse group, respectively (p = 0.015). By using a threshold of 10 SI, the specificity for relapse was 96.0 %, as only one in twenty patients with an SI above 10 went into remission during follow-up (PPV 95 %). Most TSAb-positive patients also had high levels of TBII. Neither group showed any difference with respect to blocking type autoantibodies, which were mostly negative in both groups. In summary, high TSAb levels are similar but not superior to TBII for predicting relapse in GD patients. In contrast, TBAb measurement does not add any valuable information in this context. In the clinical routine, TSAb/TBAb measurement may not play an important role for diagnosis or outcome prediction of GD, since sensitive 2 (nd) generation TBII assays are easier to perform and offer similar information to the clinician. Bioassays should be reserved for special clinical questions such as Graves' disease in pregnancy.
Supplementary Figure 2 from Nitric Oxide Boosts Chemoimmunotherapy via Inhibition of Acid Sphingomyelinase in a Mouse Model of Melanoma (2023)

Supplementary Figure 2 from Nitric Oxide Boosts Chemoimmunotherapy via Inhibition of Acid Sphingomyelinase in a Mouse Model of Melanoma
Tunable Broad Light Emission from 3D “Hollow” Bromide Perovskites through Defect Engineering (2021)

Hybrid halide perovskites consisting of corner-sharing metal halide octahedra and small cuboctahedral cages filled with counter cations have proven to be prominent candidates for many high-performance optoelectronic devices. The stability limits of their three-dimensional perovskite framework are defined by the size range of the cations present in the cages of the structure. In some cases, the stability of the perovskite-type structure can be extended even when the counterions violate the size and shape requirements, as is the case in the so-called "hollow" perovskites. In this work, we engineered a new family of 3D highly defective yet crystalline "hollow" bromide perovskites with general formula (FA)<sub>1-<i>x</i></sub>(<i>en</i>)<sub><i>x</i></sub>(Pb)<sub>1-0.7<i>x</i></sub>(Br)<sub>3-0.4<i>x</i></sub> (FA = formamidinium (FA<sup>+</sup>), <i>en</i> = ethylenediammonium (<i>en</i><sup>2+</sup>), <i>x</i> = 0-0.44). Pair distribution function analysis shed light on the local structural coherence, revealing a wide distribution of Pb-Pb distances in the crystal structure as a consequence of the Pb/Br-deficient nature and <i>en</i> inclusion in the lattice. By manipulating the number of Pb/Br vacancies, we finely tune the optical properties of the pristine FAPbBr<sub>3</sub> by blue shifting the band gap from 2.20 to 2.60 eV for the <i>x</i> = 0.42 <i>en</i> sample. A most unexpected outcome was that at <i>x</i>> 0.33 <i>en</i> incorporation, the material exhibits strong broad light emission (1% photoluminescence quantum yield (PLQY)) that is maintained after exposure to air for more than a year. This is the first example of strong broad light emission from a 3D hybrid halide perovskite, demonstrating that meticulous defect engineering is an excellent tool for customizing the optical properties of these semiconductors.
Photonic Crystal Lasers (2013)

I will review progresses of photonic crystal lasers, which are now recognized as an unprecedented type of lasers that can operate coherently in broad area, produce a tailored beam on demand, realize a beam steering functionality, etc.
An End-to-End Encryption Solution for Enterprise Content Applications (2020)

The content host services (like Dropbox, OneDrive, and Google Drive) used by enterprise customers are deployed either on premise or in cloud. Because users may store business-sensitive data (contents) in these hosting services, they may want to protect their data from disclosure to anyone else, even IT administrators. Unfortunately, even contents (files) are encrypted in the hosting services, they sometimes are still accessible to IT administrators today. The sensitive data could be exposed to public if the IT administrator turns malicious (like disgruntled employee) or his account is compromised by hackers. We propose an end-to-end encryption (E2EE) solution to address this challenge. The user data is encrypted at client side (mobile device) and remains encrypted in transit and at rest on server. Specifically, we design a new method to allow master secret recover and escrow, while protecting them from being accessed by malicious administrators. In addition, we present a content (file) encryption scheme that achieves privacy, and granular access control. And it can be seamlessly integrated with major content host services used by business users today.
Nazarov Cyclization of Bis([2.2]paracyclophane-1,9-dienyl) Ketone: First Synthesis of a Bis([2.2]paracyclophane)-Annelated Cyclopenta-1,4-diene (1998)

The annelation of five-membered rings onto the bridges of [2.2]paracyclophane-1,9-diene (1) can be achieved via Nazarov cyclization. Depending on the reaction conditions, bis([2.2]paracyclophane-1,9-dienyl) ketone (4) yielded the cy-clopentenone 8 or the α-substituted cyclopentanones 3–7 with two annelated [2.2]paracyclophane units. The synthesis of 1:2-(1:2-[2.2]paracyclophane-1,9-dieno)-4:5-(9:10-[2.2]paracyclophane-1-eno)cyclopenta-1,4-diene (10) from 8 as a potential ligand for metallocene complexes and generation of its anion 11 is also described.
A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer (2012)

The Sleeping Beauty (SB) transposon mutagenesis system is a powerful tool that facilitates the discovery of mutations that accelerate tumorigenesis. In this study, we sought to identify mutations that cooperate with MYC, one of the most commonly dysregulated genes in human malignancy. We performed a forward genetic screen with a mouse model of MYC-induced liver cancer using SB-mediated mutagenesis. We sequenced insertions in 63 liver tumor nodules and identified at least 16 genes/loci that contribute to accelerated tumor development. RNAi-mediated knockdown in a liver progenitor cell line further validate three of these genes, Ncoa2/Src-2, Zfx, and Dtnb, as tumor suppressors in liver cancer. Moreover, deletion of Ncoa2/Src-2 in mice predisposes to diethylnitrosamine-induced liver tumorigenesis. These findings reveal genes and pathways that functionally restrain MYC-mediated liver tumorigenesis and therefore may provide targets for cancer therapy.
Microendoscopic approach to far-lateral lumbar disc herniation (1999)

The purpose of this study was to determine the feasibility of performing far-lateral lumbar discectomy by using the microendoscopic discectomy (MED) technique. The authors studied 11 consecutive patients with unilateral, single-level radiculopathy secondary to far-lateral disc herniation. There were eight men and three women, with an average age of 43 years. In all patients magnetic resonance imaging and/or computerized tomography scanning documented far-lateral disc herniations. Six patients experienced motor deficits, nine patients sensory abnormalities, and five depressed reflexes. All patients complained of radicular pain, which failed to improve with conservative care. After induction of epidural anesthesia, single-level, unilateral percutaneous discectomies were performed using the MED technique. Five discectomies were performed at L3-4 and six at L4-5. There were four contained and seven sequestered disc herniations. All surgeries were performed on an outpatient basis. Follow up ranged from for 12 to 27 months. Improvement was shown in all patients postoperatively. Using modified Macnab criteria to assess results of surgery, there were 10 excellent results and one good result. None of the patients experienced residual motor deficits, four had residual decreased sensation, and one still had some degree of nonradicular pain. There were no complications. Although various open techniques exist for the treatment of far-lateral disc herniation, MED is unique in that far-lateral pathological entities can be directly visualized and removed via a 15-mm paramedian incision. The percutaneous approach avoids larger, potentially denervating and destabilizing procedures. The need for general anesthesia can be avoided, and surgery is performed on an outpatient basis, thereby reducing hospital cost and length of stay.