gebhart/patrepeval huggingface dataset:
Potent Oncolytic Activity of Raccoonpox Virus in the Absence of Natural Pathogenicity (2010)

A number of oncolytic virus (OV) candidates currently in clinical trials are human viruses that have been engineered to be safer for patient administration by limiting normal cell targeting and replication. The newest OVs include viruses that cause no disease in humans, yet still have natural tumor tropism. Raccoonpox virus (RCNV) is a member of the Orthopoxvirus genus of Poxviridae and closely related to vaccinia virus, yet has no known pathogenicity in any mammalian species. A screen of cells from the NCI-60 cancer cell panel using growth curves demonstrated greater than a log increase in replication of RCNV in nearly 74% of the cell lines tested, similar to other tested OV poxviruses. In normal cell lines, pretreatment with interferon (IFN)-alpha/beta resulted in significant inhibition of RCNV replication. In both xenograft and syngeneic models of solid tumors, injection of RCNV resulted in significantly slower tumor progression and increased survival of mice. RCNV treatment also prolonged survival in treatment-resistant models of brain tumors and decreased tumor burden by systemic administration in models of lung metastasis.
Titanated Methoxyallene as Novel Homoaldol Equivalent for Diastereoselective Additions to Chiral Amino Aldehydes (1993)

The versatile building block, methoxyallene reveals another a new facet: The titanium derivative 1 derived from it reacts with aldehydes at the γ position. Thus the methoxyalkynes anti-3 arise with high anti-selectivity on reaction of 1 with α-N,N-dibenzylamino aldehydes 2. These activated carboxylic acid derivatives can be transformed into the homostatine lactones anti-4 by hydrolysis. R  CH3, CH2Ph, CH2CHMe2.
Clinical features of multiple endocrine neoplasia type 1 in children (2022)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Thin-film transistors with amorphous indium gallium oxide channel layers (2006)

Indium gallium oxide-based thin-film transistors (TFTs) are formed using rf magnetron sputtering of the channel layer. These TFTs exhibit qualitatively ideal characteristics, including excellent drain current saturation. Various deposition parameters, annealing treatments, and stoichiometries are explored. Varying the oxygen partial pressure is found to have a significant effect on device performance. Decreasing the oxygen partial pressure increases the incremental channel mobility μinc while decreasing (becomes more negative) the turn-on voltage Von. Increasing indium concentration of the channel material increases μinc, while decreasing Von. The maximum value of μinc, ∼27cm2V−1s−1, is obtained by annealing at 600°C, with corresponding Von and drain current on-to-off ratio values of approximately −14V and &amp;gt;106, respectively. Additionally, TFTs subjected to a 200°C postdeposition annealing exhibit μinc and Von of ∼19cm2V−1s−1 and 2V, respectively.
Preparation of Microporous Si–O–C Composite Material and Its Lithium Storage Capability (2008)

Abstract A microporous Si–O–C composite material was prepared by pyrolysis of a blend of polysilane, (Ph2Si)0.85(PhSi)0.15 (1) and polystyrene (1:1 in weight) at 1000 °C. This material electrochemically performed well, offering a capacity of more than 600 mA h g−1 and a good cycle life. Our 7Li NMR analysis confirmed the possibility of several electrochemical active sites for lithium storage in this new composite material.
Performance of Single-Carrier LOS-MIMO Using FDE in 3GPP TDL Channel Models (2021)

In the future cellular systems based on heterogeneous networks (HetNets), the application of line-of-sight (LOS)-multiple-input multiple-output (MIMO) to backhaul or fronthaul between a macro cell and small cells is promising from the viewpoint of low-cost deployment. For this purpose, this paper presents the bit error rate (BER) performance of single-carrier 2 ×2 LOS-MIMO using frequency domain equalization (FDE) in the 3rd generation partnership project (3GPP) tapped delay line (TDL) channel models. Computer simulation results show the effectiveness of LOS-MIMO using FDE in the 3GPP TDL based LOS channel models.
Soft volcanic sediments compound 2006 Java earthquake disaster (2007)

When the region south of Mount Merapi volcano in central Java, Indonesia, was struck by a magnitude 6.4 earthquake, the city of Yogyakarta and its suburbs were partly devastated. The event caused severe damage to the densely inhabited area, leaving about 6000 people dead, 50,000 injured, and between 500,000 and 1 million homeless. With over 155,000 houses totally destroyed and 200,000 damaged, more houses were affected in this earthquake area than in Aceh and Nias after the earthquake‐tsunami disasters of 26 December 2004 and 28 March 2005 combined [ United Nations , 2006].
Expert-Aware Approach: A New Approach to Improve Network Security Visualization Tool (2010)

Nowadays, many computers have been infected with the computer anomalies or viruses. The availability of network security visualization tools greatly facilitate to detect, perceive and defend computer users from being affected by these anomalies. Many of the network security visualization tools are designed particularly for users with advanced network security awareness even though the tools are indispensable by various types of computer users. We proposed an expert-aware approach to designing a system which formulated with a large amount of network data or high-dimensional data and adaptive for different types of users. In the preliminary phase, we proposed and implemented initial pre-expertise classification system which provides a default setting for the expert-aware network security visualization tool. The tool will learn from continual user feedbacks in order to statistically satisfy the needs of majority tool users. The expert-aware approach looks at the users' expertise level in network security and adapts the visualization views that are best suitable for the user. Initial results of the implementation of the system show that it is capable of representing several of network security data not only on two-dimensional space on a computer but also beyond that space. Systems features, such as system effectiveness and efficiency of data visualization have been improved. Our experiments in a network lab suggest that the tool can be further improved as the tool for distribution to a wide range of computer user.
Hepatocellular carcinoma of the liver (2011)

Primary cancer of the liver, hepatocellular carcinoma (HCC), is an extremely deadly cancer, with very poor 5 year survivals, following diagnosis. The poor outcomes are believed to be due, in part, to the late times in which the cancers are usually first detected. Improved methods for early detection have thus become a top priority in the management of liver cancer. This Chapter reviews current methods of detection as well as leading new methods. Possible explanations as to why there are so many markers that are being discovered, but so few that make it to validation are discussed.
Study of Wetting of Nanostructures Using Decoration by Etching (2014)

Recent studies have shown that even inherently hydrophilic surfaces ( θ &lt; 90 ̊) can become hydrophobic as a consequence of nanopatterning (1-4). This creates an issue in semiconductor manufacturing as aqueous chemistries (e.g. dilute HF solutions) are preferred to organic chemistries for their lower cost of ownership and greener environmental profile.
Extent of load-independence of pressure-normalized stress in swine (2013)

A load-independent index of myocardial contractility provides a measure of cardiac function. Previous contractility indices have been shown to be either load-dependent or invasive. We sought to determine the extent of load (preload and afterload)-independence of d σ*/d t max ( σ* is pressure-normalized stress) in comparison with other well-established indices. Six anaesthetized pigs underwent left ventricular pressure–volume measurements under various load conditions. The average preload was decreased by 70.0 ± 15.0% (from 39.2 ± 6.4 mL to 11.7 ± 7.7 mL) and increased by 49.3 ± 5.9% (from 35.1 ± 7.4 mL to 51.7 ± 8.9 mL). The average afterload was increased by 74.3 ± 43.5% (from 3.3 ± 0.6 mmHg/mL to 5.7 ± 1.7 mmHg/mL). When preload was reduced within an average of 21.7% (39.2 ± 6.4 mL to 30.7 ± 6.2 mL) using occlusion of the inferior vena cava, d σ*/d t max did not change significantly (6.50 ± 1.10 s −1 vs 6.60 ± 0.90 s −1 , P = non-significant [NS]). When preload was increased within an average of 29.3% (35.1 ± 7.4 mL to 45.4 ± 7.3 mL) from infusion of normal saline, d σ*/d t max did not change significantly (7.04 ± 1.00 s −1 vs 7.29 ± 1.10 s −1 , P = NS). When afterload was increased within an average of 42.4% (3.3 ± 0.6 mmHg/mL to 4.7 ± 1.0 mmHg/mL) using intra-aortic balloon occlusion, d σ*/d t max did not change significantly (6.72 ± 1.18 s −1 vs 6.89 ± 1.28 s −1 , P = NS). As expected, d σ*/d t max was significantly increased with dobutamine. A linear regression showed no correlation between d σ*/d t max and preload ( r 2 = 0.02, P = 0.17) within a maximum range of −30% to +50% of preload change, or between d σ*/d t max and afterload ( r 2 = 0.03, P = 0.36) within maximum range of 0–100% of afterload increase, respectively. In conclusion, d σ*/d t max is independent of loading conditions within an average of 21.7% of preload decrease, 29.3% of preload increase, 42.4% of afterload increase, and sensitive to dobutamine infusion.
The Impact of Two-way Formative Feedback and Web-enabled Resources on Student Resource Use and Performance in Materials Courses (2015)

He teaches in the areas of introductory materials engineering, polymers and composites, and capstone design. His research interests include evaluating conceptual knowledge, misconceptions and technologies to promote conceptual change. He has co-developed a Materials Concept Inventory and a Chemistry Concept Inventory for assessing conceptual knowledge and change for introductory materials science and chemistry classes. He is currently conducting research on NSF projects in two areas. One is studying how strategies of engagement and feedback with
Pericardial Access Through the Right Atrium in a Porcine Model (2021)

As procedures such as epicardial ventricular ablation and left atrial appendage occlusion become more commonplace, the need grows for safer techniques to access the physiologic pericardial space. Because this space contains minimal fluid for lubrication, prevailing methods of pericardial access pose considerable periprocedural risk to cardiac structures. Therefore, we devised a novel method of pericardial access in which carbon dioxide (CO2) is insufflated through a right atrial puncture under fluoroscopic guidance, enabling clear visualization of the cardiac silhouette separating from the chest wall. We performed the procedure in 8 Landrace pigs, after which transthoracic percutaneous pericardial access was obtained by conventional means. All of the animals remained hemodynamically stable during the procedure, and none showed evidence of epicardial or coronary injury. The protective layer of CO2 in the pericardial space anterior to the heart facilitated percutaneous access in our porcine model, and the absence of complications supports the potential safety of this method.
247. BIOLOGICAL MARKERS OF INFLAMMATION AND PERIPROSTHETIC FRACTURE OF THE HIP (2011)

Purpose of the study: Few data are available concerning the proper management of patients with a periprosthetic fracture of the hip who presents biological signs of inflammation (increased WBC, sedimentation rate, or C-reactive protein). The purpose of this work was to determine the prevalence of elevated biological markers in this type of patient and to determine the reliability of such markers for the diagnosis of periprosthetic infection. Material and methods: A periprosthetic hip fracture was diagnosed in 204 patients from 2000 to 2006. The WBC count, the sedimentation rate and the serum CRP level were noted at admission to the emergency ward. The diagnosis of infection was confirmed by at least two positive bacteriological samples of tissue biopsy and/or joint fluid collected at surgery. A statistical analysis was conducted to determine the prevalence of elevated biological markers of inflammation, the sensitivity, their specificity and their positive predictive value for deep infection. Results: Twenty-one patients (11.6%) developed a periprosthetic infection. Among the 204 patients, the WBC count increased in 16.2%, sedimentation rate in 33.3% and CRP in 50.5%. The sensitivity was 24% (WBC), 50% (sedimentation rate) and 83% (CRP). The specificity was 85% (WBC), 69% (sedimentation rate) and 56% (CRP). The positive predictive value was low (18, 21 and 29% respectively). Discussion: Markers of inflammation are frequently ordered before surgery to search for infection but can be elevated for various reasons. Most often, these markers are elevated because of the patient’s general status and are thus related to other co-morbid conditions and/or reaction to the new fracture. In this population, the WBC count did not contribute to the diagnosis of infection as only 24% of the infected patients had a high count. CRP and sedimentation rate and the WBC count had low positive predictive values. Conclusion: This study shows that an isolated elevation of biological markers of inflammation in a patient with a periprosthetic fracture is not a good indicator of infection.
Reversible, nitrogen-assisted migration of a phenyl group from phosphorus to iron in CpFe(CO)[PhP(OCH2CH2)2NH]+PF6- (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReversible, nitrogen-assisted migration of a phenyl group from phosphorus to iron in CpFe(CO)[PhP(OCH2CH2)2NH]+PF6-Pierre Vierling, Jean G. Riess, and Andre GrandCite this: J. Am. Chem. Soc. 1981, 103, 9, 2466–2467Publication Date (Print):May 1, 1981Publication History Published online1 May 2002Published inissue 1 May 1981https://pubs.acs.org/doi/10.1021/ja00399a080https://doi.org/10.1021/ja00399a080research-articleACS PublicationsRequest reuse permissionsArticle Views95Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
TT 33 – Tombe de Padiaménopé (Thèbes-ouest, 2021) (2022)

Suite un premier sondage limit, ralis lors de la campagne 2019, la fouille a t tendue au sol de la nef centrale et de la nef latrale sud de la premire salle hypostyle, soit environ 2/3 de sa surface, ainsi qu'aux deux passages reliant la salle au porche d'une part et la deuxime salle hypostyle d'autre part, pour une surface totale d'environ 115 m 2 pour une profondeur maximale d'une cinquantaine de centimtres (fig.
Studies in Polyphenol Chemistry and Bioactivity. 1. Preparation of Building Blocks from (+)-Catechin. Procyanidin Formation. Synthesis of the Cancer Cell Growth Inhibitor, 3-O-Galloyl-(2R,3R)-epicatechin-4β,8-[3-O-galloyl-(2R,3R)-epicatechin] (1999)

A project has been initiated to synthesize proanthocyanidin oligomers found in cocoa. Natural, readily available (+)-catechin was transformed into 5,7,3‘,4‘-tetra-O-benzyl-(−)-epicatechin (14) by (a) benzylation of the phenolic oxygens; (b) oxidation of the 3-alcohol to ketone by the Dess−Martin periodinane; and (c) reduction with lithium tri-sec-butylborohydride (l-Selectride) in the presence of LiBr. The additive diminishes the extent of ketone enolization while maintaining a stereoselectivity of ≥200:1. Oxidation of 14 with DDQ was performed best from the standpoint of product purification if ethylene glycol was used as the nucleophilic trapping agent. The resulting ether 19 was condensed with 14 using TiCl4 to give a good yield of benzyl-protected epicatechin-4β,8-epicatechin (octa-O-benzylprocyanidin B2, 20) as the sole dimeric product. Hydrogenolysis of 20 yielded procyanidin B2 in the first enantiospecific synthesis of this natural product which employs protected intermediates and thereby allows the necessary product separation after the condensation step to be performed on nonpolar, nonsensitive intermediates. Acylation of 20 with tri-O-benzylgalloyl chloride followed by hydrogenolysis gave access to the title bis-gallate (24). This constitutes the first synthesis of this natural product, a compound notable for its PKC-inhibitory and anticancer activity.
Effects of costimulation of dopamine D1- and D2-like receptors on renal function (1998)

In vitro studies have suggested that dopamine D1- and D2-like receptors interact to inhibit renal sodium transport. We used Z-1046, a dopamine receptor agonist with the rank-order potency D3 >/= D4 > D2 > D5 > D1, to test the hypothesis that D1- and D2-like receptors interact to inhibit renal sodium transport in vivo in anesthetized rats. Increasing doses of Z-1046, administered via the right renal artery, increased renal blood flow (RBF), urine flow, and absolute and fractional sodium excretion without affecting glomerular filtration rate. For determination of the dopamine receptor involved in the renal functional effects of Z-1046, another group of rats received Z-1046 at 2 microgram . kg-1 . min-1 (n = 10) in the presence or absence of the D2-like receptor antagonist domperidone and/or the D1-like antagonist SCH-23390. Domperidone alone had no effect but blocked the Z-1046-mediated increase in urine flow and sodium excretion; it enhanced the increase in RBF after Z-1046. SCH-23390 by itself decreased urine flow and sodium excretion without affecting RBF and blocked the diuretic, natriuretic, and renal vasodilatory effect of Z-1046. We conclude that the renal vasodilatory effect of Z-1046 is D1-like receptor dependent, whereas the diuretic and natriuretic effects are both D1- and D2-like receptor dependent.
Structural insights into glycine reuptake inhibition (2020)

Abstract The human glycine transporter 1 (GlyT1) regulates glycine mediated neuronal excitation and inhibition through sodium- and chloride-dependent reuptake of the neurotransmitter 1-3 . Inhibition of glycine reuptake via GlyT1 prolongs neurotransmitter signaling and has long served as a key therapeutic development strategy for treatment of a broad range of central nervous system disorders including schizophrenia and cognitive impairments 4 . Using an inhibition state-selective sybody and serial synchrotron crystallography, we determined the structure of GlyT1 in complex with a benzoylpiperazine chemotype inhibitor at 3.4 Å resolution. The inhibitor locks GlyT1 in an inward-open conformation and binds at the intracellular gate of the release pathway, overlapping with the glycine release site. The inhibitor likely reaches GlyT1 from the cytoplasmic leaflet of the plasma membrane. The study defines the mechanism of non-competitive inhibition and enables the rational design of new, clinically efficacious GlyT1 inhibitors.
Recasting the feedback debate: benefits of tutoring error detection and correction skills (2003)

Traditionally, intelligent tutoring systems have provided feedback on the basis of a so-called expert model. Expert model tutors incorporate production rules associated with error free and efficient task performance. These systems intervene with corrective feedback as soon as a student deviates from a solution path. This thesis explores the effects of providing feedback on the basis of a so-called intelligent novice cognitive model. An intelligent novice tutor allows students to make errors, and provides guidance through the exercise of error detection and correction skills. The underlying cognitive model in such a tutor includes both rules associated with solution generation, and rules relating to error detection and correction. There are two pedagogical motivations for feedback based on an intelligent novice model. First, novice performance is often error prone and students may need error detection and correction skills in order to succeed in real world tasks. Second, the opportunity to reason about the causes and consequences of errors may allow students to form a better model of the behavior of domain operators. Learning outcomes associated with the two models were experimentally evaluated. Results show that learners who receive intelligent novice feedback demonstrate better learning overall, including better retention and transfer performance than students receiving expert model based feedback.
Speech Enhancement of Movie Sound (2008)

Today, many people have problems understanding the speech content of a movie, e.g. due to hearing impairments. This paper describes a method for improving the speech intelligibility of movie sound. Speech is detected by means of a pattern recognition method; the audio signal is then attenuated during periods where speech is absent. The speech signals are further processed by a spectral weighting method aiming at the suppression of the background noise. The spectral weights are computed by means of feature extraction and a neural network regression method. The output signal finally carries all relevant speech with reduced background noise allowing the listener to follow the plot of the movie more easily. Results of numerical evaluations and of listening tests are presented.
Thermo‐chemical conversion of biomass and upgrading to biofuel: The Thermo‐Catalytic Reforming process – A review (2019)

Abstract Thermo‐catalytic reforming (TCR®) is a promising conversion technology for the production of liquid bio‐fuels. The process is a proven opportunity to convert biological wastes and residues into hydrogen‐rich syngas, high‐quality oil, and char without volatiles. Bio‐oil produced from TCR® has a high carbon content, low water content, low oxygen content, and a high heating value; it is therefore directly applicable as feed in boilers or as blend in dual fuel engines. A feasible opportunity for using bio‐oil in automotive combustion engines is a further upgrade step to bio‐fuel by hydrogenation. During this hydrotreatment, heterogeneous atoms like sulfur, nitrogen, and oxygen are removed or substituted with hydrogen. Fraunhofer UMSICHT already produces gasoline and diesel that comply with European fuel standards EN 228 and EN 590, using different catalysts like NiMo/Al 2 O 3 , CoMo/Al 2 O 3 , and Ru/C for hydrogenation at 643 K and a constant hydrogen pressure of 14 MPa. Various hydrocarbons and benzene derivatives are verified after hydrotreating. © 2019 Society of Chemical Industry and John Wiley &amp; Sons, Ltd.