gebhart/patrepeval huggingface dataset:
Formation of a TiO2 Micronetwork on a UV-Absorbing SiO2-Based Glass Surface by Excimer Laser Irradiation (2005)

We report on the preparation of TiO2 micronetworks on a UV-absorbing Na2O−TiO2−SiO2 glass surface by excimer laser irradiation, a technique we have called laser-induced superficial phase separation. The TiO2 micronetworks that were formed on the etched glass surface were in the rutile crystalline phase and exhibited a photocatalytic capability. We were also able to form a range of TiO2 micronetworks in an array of 20-μm holes. This flexible formation of photocatalytic TiO2 networks on a glass surface without any heat treatments could enable a new route for developing novel microdevices, such as monolithic microfluidics with light-catalyzed reactions and miniaturized solar batteries.
1-D Air-snowpack modeling of atmospheric nitrous acid at South Pole during ANTCI 2003 (2008)

Abstract. A 1-D air-snowpack model of HONO has been developed and constrained by observed chemistry and meteorology data. The 1-D model includes molecular diffusion and mechanical dispersion, windpumping in snow, gas phase to quasi-liquid layer phase HONO transfer and quasi-liquid layer nitrate and interstitial air HONO photolysis. Photolysis of nitrate is important as a dominant HONO source inside the snowpack, however, the observed HONO emission from the snowpack was triggered mainly by the equilibrium between quasi liquid layer nitrite and firn air HONO deep down the snow surface (i.e. 30 cm below snow surface). The high concentration of HONO in the firn air is subsequently transported above the snowpack by diffusion and windpumping. The model uncertainties come mainly from lack of measurements and the interpretation of the QLL properties based on the bulk snow measurements. One critical factor is the ionic strength of QLL nitrite, which is estimated here by the bulk snow pH, nitrite concentration, and QLL to bulk snow volume ratio.
Abnormal splice variants of SIVA in Waldenstrom’s macroglobulinemia (WM). (2008)

AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA

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Waldenstrom’s macroglobulinemia (WM) is an incurable B cell malignancy characterized by the accumulation of IgM secreting lymphoplasmacytic cells (LPC). Despite intense research efforts, the mechanism(s) by which WM LPC fail to undergo apoptosis remain to be defined. One potential mechanism for B-cell homeostasis is signaling of CD70 through CD27, which induces apoptosis in normal B-cells including CD27+ memory B-cells from which WM LPC are thought to derive. WM cells often show no or diminished expression of CD27, or secrete high levels of soluble CD27 which may lead to CD70 signaling blockade (Ho et al, Blood 2008). As part of these effort we sought to elaborate on intracellular mechanisms for CD70-CD27 signaling, by focusing on SIVA, a pro -apoptotic proteincontaining a death domain which interacts with the cytoplasmic tail of CD27. Two splice variants of SIVA ( SIVA1 and SIVA2) have so far been identified in humans . We therefore evaluated the expression patterns of SIVA in 25 WM patients and 6 healthy donors (HD). Through gene profiling, we detected the constitutive expression of SIVA 1 and its variant SIVA2 , which results from deletion of exon 2. However, in contrast to previous findings, we detected three novel aberrant splice variants of SIVA , which we have designated as SIVA-Va, -Vb, and -Vc, at least one of which alone or combination with each other were present in 25/25 patients with WM versus 1/6 HD (p=0.00004). The breakdown for the frequency of expression for these variants in WM patients was as follows: SIVA -Va (10/25); -Vb (6/25); -Vc (13/25), whereas in HD only SIVA-Vc was present in one individual. Cloning, sequencing and alignment analysis of SIVA variants from 4 WM patients revealed that SIVA-Va and SIVA-Vb resulted from partial intron retention, while SIVA-Vc was derived from the deletion of two exons. DNA alignment and bioinformatics analysis demonstrated that all splice variants of SIVA encoded for novel proteins. This prediction was verified by transient tranfection of GFP-SIVA-FL and DsRed-SIVA variant constructs into HeLa cells. As expected, SIVA-FL protein was expressed in the nucleus and transported to the membrane, while splice variants were localized on the membrane. Co-transfection analysis of SIVA-FL and splice variants verified their co-localization at the membrane 6 hours after proteins production. The results of these studies suggest that SIVA variants compete for CD27 binding and may therefore interfere with B-cell homeostasis regulated by CD70-CD27 interactions.
Transient photoluminescence and simultaneous amplified spontaneous emission from multiexciton states inCdSequantum dots (2004)

We use transient photoluminescence to spectrally resolve the emission from 1, 2, and 3 electron-hole pairs states in $\mathrm{CdSe}$ colloidal quantum dots with radii ranging between 2.3 and $5.2\phantom{\rule{0.3em}{0ex}}\mathrm{nm}$. The power dependence of the triexciton, biexciton and single exciton emission intensities are reported. We incorporate $\mathrm{CdSe}∕\mathrm{ZnS}$ core-shell nanocrystals into a ${\mathrm{TiO}}_{2}$ host matrix and observe simultaneous amplified spontaneous emission from the $1{\mathrm{S}}_{3∕2}\text{\ensuremath{-}}1\mathrm{Se}$ and $1{\mathrm{P}}_{3∕2}\text{\ensuremath{-}}1{\mathrm{P}}_{\mathrm{e}}$ quantum dot transitions. The achievement of amplified spontaneous emission from the $1{\mathrm{P}}_{\mathrm{e}}$ QD state suggests that the $1{\mathrm{P}}_{\mathrm{e}}$ state sixfold degeneracy might be lifted by the $\mathrm{e}\text{\ensuremath{-}}\mathrm{h}$ exchange interaction.
Improved Electrical Performance Thanks to Sb and N Doping in Se-Rich GeSe-Based OTS Selector Devices (2017)

In this paper, we investigate the impact of Sb and N doping in Se-rich GeSe based Ovonic Threshold Switching (OTS) selector devices, targeting crossbar memory applications. Through physico-chemical analysis and electrical characterization we demonstrate that Sb doping allows low threshold voltage switching operations, while N doping improves the OFF state resistance stability of Se-rich GeSe based selector devices. Thus, we are able to demonstrate an endurance up to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> cycles, an ON/OFF current ratio of ~ 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8</sup> and reading selectivity of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> . These values are among the best reported in the literature for an OTS selector. The described material engineering makes Se-rich GeSe based materials suitable for Back-End of Line (BEOL) selector integrations, such as resistive memory crossbar arrays up to 1Mb.
Subspace dimension estimation for equalization of underwater acoustic channels. (2011)

The use of an array of receiving elements has several advantages such as increased signal to noise ratio due to array gain and the ability form beams, which reject interference and enhance a source. One common way to integrate an array receiver into a communication system is through the use of a multichannel decision feedback equalizer (DFE), which adaptively combines the signals from the receive elements and mitigates channel effects. However, the computational complexity of a multichannel DFE is too high for implementation into real-time systems. One solution is to use a beamformer to reduce the number of channels the DFE needs to combine and thus reducing the overall complexity. While there has been some research showing the optimal number of beams if the channel is known, it is still an open question how to determine this information from a received signal. This research examines approaches for determining the number of beams to use so that the performance of a reduced complexity beamformer-DFE system is at least as good as a system, which uses multichannel DFE with all of the sensors as inputs. Results will be presented from experimental data comparing the performance of the systems in different ocean environments.
Facile promotion of oxidative dehydrogenation by iron ions and the synthesis of new complexes of iron with highly unsaturated tetraaza macrocycles (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFacile promotion of oxidative dehydrogenation by iron ions and the synthesis of new complexes of iron with highly unsaturated tetraaza macrocyclesVirgil L. Goedken and Daryle H. BuschCite this: J. Am. Chem. Soc. 1972, 94, 21, 7355–7363Publication Date (Print):October 1, 1972Publication History Published online1 May 2002Published inissue 1 October 1972https://pubs.acs.org/doi/10.1021/ja00776a016https://doi.org/10.1021/ja00776a016research-articleACS PublicationsRequest reuse permissionsArticle Views286Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On effective classification of strings with wavelets (2002)

In recent years, the technological advances in mapping genes have made it increasingly easy to store and use a wide variety of biological data. Such data are usually in the form of very long strings for which it is difficult to determine the most relevant features for a classification task. For example, a typical DNA string may be millions of characters long, and there may be thousands of such strings in a database. In many cases, the classification behavior of the data may be hidden in the compositional behavior of certain segments of the string which cannot be easily determined apriori. Another problem which complicates the classification task is that in some cases the classification behavior is reflected in global behavior of the string, whereas in others it is reflected in local patterns. Given the enormous variation in the behavior of the strings over different data sets, it is useful to develop an approach which is sensitive to both the global and local behavior of the strings for the purpose of classification. For this purpose, we will exploit the multi-resolution property of wavelet decomposition in order to create a scheme which can mine classification characteristics at different levels of granularity. The resulting scheme turns out to be very effective in practice on a wide range of problems.
Feasibility of Auditory Cortical Stimulation for the Treatment of Tinnitus (2007)

Chronic electrical stimulation of the secondary auditory cortex seems safe and warrants further investigation as a potential therapeutic intervention for the suppression of tinnitus.
Synthesis Conditions and Electrochemical Properties of High Tap Density Spherical C-LiFePO4 via Co-Precipitation (2007)

Abstract not Available.
[C11]Methionine Quantitation in Cancer PET Studies (1992)

Quantitation of the uptake of positron emitting tracers in cancer patients is still unsettled. A uniform method is needed for comparison of results and for collecting a data base of tumor PET studies. We have measured the tumoral uptake of [11C]methionine in 46 cancer patients using four different methods of analysis. The accumulation of [11C]methionine at 35-40 min after the injection adjusted to the injected dose and body surface area turned out to give similar results as a more complicated method where the uptake rate of [11C]methionine from the plasma to the tumor was calculated (r = 0.92, p less than 0.0001). The results suggest that in clinical [11C]methionine PET studies, 40 min emission scanning with frequent blood sampling is unnecessary. Only a single 5 min emission scan 25-40 min after the injection is required for analysis if the accumulation is adjusted to the injected dose and body surface area.
Detectability of Galactic Faraday Rotation in multiwavelength CMB observations (2017)

We introduce a new cross-correlation method to detect and verify the astrophysical origin of Faraday Rotation (FR) in multiwavelength surveys. FR is well studied in radio astronomy from radio point sources but the λ2 suppression of FR makes detecting and accounting for this effect difficult at millimeter and sub-millimeter wavelengths. Therefore, statistical methods are used to attempt to detect FR in the cosmic microwave background (CMB). Most estimators of the FR power spectrum rely on single-frequency data. In contrast, we investigate the correlation of polarized CMB maps with FR measure maps from radio point sources. We show a factor of ∼30 increase in sensitivity over single-frequency estimators and predict detections exceeding 10σ significance for a CMB-S4-like experiment. Improvements in observations of FR from current and future radio polarization surveys will greatly increase the usefulness of this method.
A Freestanding Stretchable and Multifunctional Transistor with Intrinsic Self‐Healing Properties of all Device Components (2018)

A flexible and stretchable field-effect transistor (FET) is an essential element in a number of modern electronics. To realize the potential of this device in harsh real-world conditions and to extend its application spectrum, new functionalities are needed to be introduced into the device. Here, solution-processable elements based on carbon nanotubes that empower flexible and stretchable FET with high hole-mobility (µ<sub>h</sub> ≈ 10 cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup> ) and relatively low operating voltages (<8 V) and that retain self-healing properties of all FET components are reported. The device has repeatable intrinsic and autonomic self-healing ability, namely without use of any external trigger, enabling the restoration of its electrical and mechanical properties, both after microscale damage or complete cut of the device-for example by a scissor. The device can be repeatedly stretched for >200 cycles of up to 50% strain without a significant loss in its electrical properties. The device is applicable in the form of a ≈3 µm thick freestanding skin tattoo and has multifunctional sensing properties, such as detection of temperature and humidity. With this unprecedented biomimetic transistor, highly sustainable and reliable soft electronic applications can be introduced.
Survival and Feeding Rates of Four Aphid Species (Hemiptera: Aphididae) on Various Sucrose Concentrations in Diets (2017)

Different concentrations of sucrose were used to investigate how survival and feeding was affected in four species of aphids (Hemiptera: Aphididae). Seven sucrose concentrations were evaluated in feeding chambers fitted with parafilm membranes and infested with nymphs of Aphis glycines Matsumura, Diuraphis noxia Kurdjumov, Myzus persicae Sulzer, or Schizaphis graminum Rondani at 25 °C and a photoperiod of 14:10 (L:D) h. Survival on each diet was recorded 1, 3, 5, 7, 9, and 11 d. Diet volumes (μl) consumed and amounts of honeydew produced were then determined. Aphid survival differed significantly by concentration, time (d), and aphid species. Aphis glycines survival was highest (83.8%) on 30% sucrose although percent survival in the 70's occurred on concentrations ranging from 15-25%. Diuraphis noxia survival was highest on the 15 and 20% sucrose concentrations. Survival for Myzus persicae was optimal on 20% sucrose (92%) but did not differ that much (5%) on concentrations of 15-35%. Schizaphis graminum survival (93.0-93.6%) was highest on sucrose concentrations ranging from 20-30% sucrose. Myzus persicae and S. graminum, which feed on a wide-range of host plants, were overall more adapted to feeding on a wider range of sucrose concentrations than the more host-restricted aphid species, A. glycines. Diet consumption by A. glycines did not vary on the sucrose concentrations, but D. noxia and M. persicae exhibited increased consumption on diets that provided optimal survival. Results will aid in the design of short-term studies using sucrose-only diets to evaluate effects of bioactive materials on aphid survival for up to 11 d.
Generation of Leukemia Inhibitory Factor and Basic Fibroblast Growth Factor-Dependent Induced Pluripotent Stem Cells from Canine Adult Somatic Cells (2011)

For more than thirty years, the dog has been used as a model for human diseases. Despite efforts made to develop canine embryonic stem cells, success has been elusive. Here, we report the generation of canine induced pluripotent stem cells (ciPSCs) from canine adult fibroblasts, which we accomplished by introducing human OCT4, SOX2, c-MYC, and KLF4. The ciPSCs expressed critical pluripotency markers and showed evidence of silencing the viral vectors and normal karyotypes. Microsatellite analysis indicated that the ciPSCs showed the same profile as the donor fibroblasts but differed from cells taken from other dogs. Under culture conditions favoring differentiation, the ciPSCs could form cell derivatives from the ectoderm, mesoderm, and endoderm. Further, the ciPSCs required leukemia inhibitory factor and basic fibroblast growth factor to survive, proliferate, and maintain pluripotency. Our results demonstrate an efficient method for deriving canine pluripotent stem cells, providing a powerful platform for the development of new models for regenerative medicine, as well as for the study of the onset, progression, and treatment of human and canine genetic diseases.
Parallel Enriched Algebraic Multiscale Solver (2017)

Abstract A Parallel Enriched Algebraic Multiscale Solver (PEAMS) for simulation of flow in heterogeneous formations with high contrasts is introduced. Built on the recently developed enrichment strategy for single processing algorithms, i.e., EAMS of Manea et al. (2016), the PEAMS describes an efficient parallel implementation procedure as to how to enrich a given multiscale formulation with additional local basis functions. These additional basis functions, constructed in parallel computational platform, aim to resolve large error components for a generic fine-scale system with no right-hand-side term. The design and computational overhead of the enrichment kernels in shared-memory parallel environments are discussed in detail. The robustness and scalability of PEAMS are then illustrated for highly heterogeneous and anisotropic 3D multi-milion-cell reservoir models. The presented results show that, by adding only a few locally- supported complementary basis functions, the convergence of the original multiscale method is significantly enhanced. This is achieved with incurring a marginal overhead in the complexity to the coarse-scale operator. Moreover, in shared-memory parallel environments, it is shown that both of the enrichment procedure and the resulting enriched solver are scalable. Therefore, PEAMS casts a promising framework for robust iterative multiscale formulations for real-field applications, where parallel processing architectures are essential.
The Induction of Cyclooxygenase-2 mRNA in Macrophages Is Biphasic and Requires both CCAAT Enhancer-binding protein β (C/EBPβ) and C/EBPδ Transcription Factors (2001)

Prostaglandins are important mediators of activated macrophage functions, and their inducible synthesis is mediated by cyclooxygenase-2 (COX-2). Here, we make use of the murine macrophage cells RAW264 as well as of immortalized macrophages derived from mice deficient for the transcription factor CCAAT enhancer-binding protein beta (C/EBP beta) to explore the molecular mechanisms regulating COX-2 induction in activated macrophages. We demonstrate that lipopolysaccharide-mediated COX-2 mRNA induction is biphasic. The initial phase is independent of de novo protein synthesis, correlates with cAMP-response element-binding protein (CREB) activation, is inhibited by treatments that abolish CREB phosphorylation and reduce NF-kappa B-mediated gene activation, and requires the presence of the transcription factor C/EBP beta. On the other hand, C/EBP delta appears to be essential in addition to C/EBP beta to effect the second phase of COX-2 gene transcription, which is important for maintaining the induced state and requires de novo protein synthesis. Indeed, both phases of COX-2 induction were defective in C/EBP beta-/- macrophages. Moreover, the synthesis of C/EBP delta was increased dramatically by treatment with lipopolysaccharide and, like COX-2 induction, repressed by combined inhibition of the MAPK and of the SAPK2/p38 cascades. Taken together, these data identify CREB, NF-kappa B, and both C/EBP beta and -delta as key factors in coordinately orchestrating transcription from the COX-2 promoter in activated macrophages.
Computer‐based engineering of thermostabilized antibody fragments (2019)

We used the molecular modeling program Rosetta to identify clusters of amino acid substitutions in antibody fragments (scFvs and scAbs) that improve global protein stability and resistance to thermal deactivation. Using this methodology, we increased the melting temperature (T<sub>m</sub>) and resistance to heat treatment of an antibody fragment that binds to the <i>Clostridium botulinum</i> hemagglutinin protein (anti-HA33). Two designed antibody fragment variants with two amino acid replacement clusters, designed to stabilize local regions, were shown to have both higher T<sub>m</sub> compared to the parental scFv and importantly, to retain full antigen binding activity after 2 hours of incubation at 70 °C. The crystal structure of one thermostabilized scFv variants was solved at 1.6 Å and shown to be in close agreement with the RosettaAntibody model prediction.
Mesoatom alloys via self-sorting approach of giant molecules blends (2020)

The bottom-up construction of Frank–Kasper (FK) phases in soft matter requires intricating tuning to balance entropic and enthalpic interactions. In contrast, sophisticated rules have been established in Metallurgy to dictate the packing structures of metal alloys. Inspired by alloy metallurgy, we develop a new self-sorting approach to construct nanostructures in condensed soft matters. This approach utilizes blends of nano-sized giant molecules to construct supramolecular motifs (“mesoatoms”) with controlled size heterogeneity, which is the key in rational design of diverse FK nanostructures. Especially, the scarcely observed thermodynamically stable Laves C14 and C15 phases are widely found. This approach sheds light on next-generation material engineering which allows nanostructure construction in a more predictable and straightforward way
Session Initiation Protocol (SIP) User Agent Capability Extension to Presence Information Data Format (PIDF) (2008)

Presence Information Data Format (PIDF) defines a common presence data format for Common Profile for Presence (CPP) compliant presence protocols. This memo defines a PIDF extension to represent SIP User Agent capabilities.