gebhart/patrepeval huggingface dataset:
p35/Cyclin-Dependent Kinase 5 Phosphorylation of Ras Guanine Nucleotide Releasing Factor 2 (RasGRF2) Mediates Rac-Dependent Extracellular Signal-Regulated Kinase 1/2 Activity, Altering RasGRF2 and Microtubule-Associated Protein 1b Distribution in Neurons (2004)

Cyclin-dependent kinase 5 (Cdk5) is a proline-directed kinase the activity of which is dependent on association with its neuron-specific activators, p35 and p39. Cdk5 activity is critical for the proper formation of cortical structures and lamination during development. In the adult nervous system, Cdk5 function is implicated in cellular adhesion, dopamine signaling, neurotransmitter release, and synaptic activity. In addition, Cdk5 is also involved in "cross-talk" with other signal transduction pathways. To further examine its involvement in cross-talk with other pathways, we identified proteins that interacted with p35 using the yeast two-hybrid system. We report here that p35 associates with Ras guanine nucleotide releasing factor 2 (RasGRF2) in coimmunoprecipitation and colocalization studies using transfected cell lines as well as primary cortical neurons. Additionally, Cdk5 phosphorylates RasGRF2 both in vitro and in vivo, leading to a decrease in Rac-guanidine exchange factor activity and a subsequent reduction in extracellular signal-regulated kinase 1/2 activity. We show that p35/Cdk5 phosphorylates RasGRF2 on serine737, which leads to an accumulation of RasGRF2 in the neuronal cell bodies coinciding with an accumulation of microtubule-associated protein 1b. The membrane association of p35 and subsequent localization of Cdk5 activity toward RasGRF2 and Rac provide insights into important cellular signaling processes that occur at the membrane, resulting in downstream effects on signal transduction cascades.
EMI Sensing for Underwater Metallic Targets Detection and Classification (2019)

Electromagnetic induction (EMI) sensing phenomenon are investigated for a conducting and multilayer environment to aid in underwater unexploded ordnance (UXO) detection and classification. The marine environment introduces complexities, such salinity gradient, sharp conductivity changes at air-water-sediment etc., which adversely can affect targets EMI signals and make underwater targets classification more difficult problem than classifying the same buried targets on land. The sensitivity of a secondary EMI signal with respect the water/air and/or water/sediment boundaries and temporal (diffusive EM field propagation speed) variability of EMI fields in an underwater (UW) environment are studied and demonstrated using the unconditionally stable Crank-Nicolson finite different time domain method (FDTD).
Loss-Based Cross-Validated Deletion/Substitution/Addition Algorithms in Estimation (2004)

In van der Laan and Dudoit (2003) we propose and theoretically study a unified loss function based statistical methodology, which provides a road map for estimation and performance assessment. Given a parameter of interest which can be described as the minimizer of the population mean of a loss function, the road map involves as important ingredients cross-validation for estimator selection and minimizing over subsets of basis functions the empirical risk of the subset-specific estimator of the parameter of interest, where the basis functions correspond to a parameterization of a specified subspace of the complete parameter space. In this article we first review this approach. Then we propose a general deletion/substitution/addition algorithm for minimizing over subsets of variables (e.g., basis functions) the empirical risk of subset-specific estimators of the parameter of interest. In particular, in the regression context, this algorithm corresponds to minimizing over subsets of variables the sum of squared residuals of the subset-specific linear regression estimator. This algorithm provides us with a new class of loss-based cross-validated algorithms in prediction of univariate and multivariate outcomes, conditional density and hazard estimation, and we generalize it to censored outcomes such as survival. In the context of regression, using polynomial basis functions, we study the properties of the deletion/substitution/addition algorithm in simulations and apply the method to detect binding sites in yeast gene expression experiments.
A new adjustment method for the frequency-dependent IMD compensator of the digital predistortion linearizer (2006)

A new adjustment method is proposed that controls the frequency characteristics compensator of a digital predistortion linearizer (DPDL) when modulated signals are input for digital mobile communications. The digital predistortion linearizer is equipped with an odd-order distortion generator, a vector regulator and a frequency characteristics compensator in the distortion generation paths. In order to compensate the frequency-dependent intermodulation distortion (IMD) components, the proposed method divides them into narrow bandwidth segments whose frequency characteristics can be approximated as flat. The proposed method ensures that the frequency characteristics compensator has uniform amplitude and phase in each segment and adjusts them repeatedly until the IMD components are suppressed in all segments. Experiments show that the DPDL with the proposed method can compensate frequency-dependent IMD. Adjacent channel leakage power ratios at /spl plusmn/5 MHz offset frequency are suppressed to under -45 dB at the output back-off point of 6.6 dB from the saturation output power for a root roll-off QPSK signal.
Leadership Primer for Current and Aspiring Pulmonary, Critical Care, and Sleep Medicine Academic Division Chiefs (2018)

An academic medical career traditionally revolves around patient care, teaching, and scholarly projects. Thus, when an opportunity for a leadership role arises, such as division chief, the new leader is often unprepared with little or no formal leadership training. In this focused review, academic leaders of the Association of Pulmonary, Critical Care, and Sleep Division Directors describe several leadership concepts adapted from the business sector and apply their years of experience to aid new division chiefs with their first day on the job. The first 90 days are highlighted to include achieving early wins; performing a division-wide Strengths, Weaknesses, Opportunities, Threats analysis; establishing division rapport; redefining the division infrastructure; avoiding conflicts; and managing the relationship with the department chair. The five levels of leadership applicable to academic medicine are discussed: position, permission, production, people, and pinnacle. Finally, emotional intelligence and behavior styles crucial to leadership success are reviewed.
Polysaccharide Materials: Performance by Design (2009)

Polysaccharide chemistry is at a watershed moment. We have seen once-vigorous areas of science and industry decline, such as textile and paper chemistry. Yet, simultaneously, vast new frontiers are opening before us, because of the increasing demand for and decreasing supply of petroleum, and the growing appreciation for the enormous flexibility and information content of polysaccharides. The emerging biorefinery-based economy offers almost unlimited potential for contributions from polysaccharide chemists, in order to solve difficult problems associated with the conversion of biomass into biofuels and biomaterials. It would be difficult to imagine a field with more potential for global impact. At the same time, polysaccharide scientists are challenged to solve long standing scientific problems that could aid in meeting these critical global challenges, including the determination of fine structure, controlled synthesis, and elucidation of detailed structure-property relationships for polysaccharides and derivatives. Here I present a viewpoint on the state of the art, and the major challenges ahead for polysaccharide chemistry.
Primary Total Hip Arthroplasty with Use of the Modular S-ROM Prosthesis. Four to Seven-Year Clinical and Radiographic Results* (1999)

Use of the modular S-ROM femoral prosthesis yielded excellent intermediate-term outcomes with respect to standard radiographic and clinical criteria. The issue regarding the theoretical increase in the rate of osteolysis due to metal debris generated at the modular femoral stem-sleeve junction was specifically addressed. We found that the rate of osteolysis in this series was not notably higher than that in other series reported in the orthopaedic literature. Although many possible factors may influence the rate of osteolysis in total hip arthroplasty, this finding suggests that the potential increase in osteolysis theoretically associated with this modular femoral implant was not observed at intermediate-term follow-up. Although longer follow-up is warranted so that the potential for osteolysis can be evaluated fully, no osteolytic lesions were evident distal to the stem-sleeve interface at the time of intermediate-term follow-up. This finding suggests that there is a circumferential seal at the modular junction of the stem that prevents the distal egress of wear debris.
A low-power, high-speed, 9-channel germanium-silicon electro-absorption modulator array integrated with digital CMOS driver and wavelength multiplexer (2014)

We demonstrate the first germanium-silicon C-band electro-absorption based waveguide modulator array and echelle-grating-based silicon wavelength multiplexer integrated with a digital CMOS driver circuit. A 9-channel, 10Gbps SiGe electro-absorption wavelength-multiplexed modulator array consumed a power of 5.8mW per channel while being modulated at 10.25Gbps by 40nm CMOS drivers delivering peak-to-peak voltage swings of 2V, achieving a modulation energy-efficiency of ~570fJ/bit including drivers. Performance up to 25Gbps on a single-channel SiGe modulator and CMOS driver is also reported.
WDM Transmission of 127 Gb/s PM-QPSK Signal over 3,350 km SMF-only Line with Chromatic Dispersion Compensation using Real-Time DSP-LSI (2012)

We experimentally demonstrated 127 Gb/s PM-QPSK signal transmission in 50 GHz-spacing 5-channel WDM configuration over 3,350 km SMF-only line. 56,200 ps/nm of chromatic dispersion was compensated by overlap FDE implemented on real-time DSP-LSI.
MEMS-based Angular and Spatial Light Modulation for Lidar and AR Displays (2020)

High-speed, monolithic and MEMS-based lidar and a large pixel count micro display device for AR display optics leverages a Digital Micromirror Device with a pulsed illumination that simultaneous modulates light in space and angular domain.
Laser physics of Nd3+-doped phosphate glasses (1994)

Nd-doped glasses have emerged as one of a handful of laser materials that are routinely employed in scientific and commercial applications. As a consequence, it is of interest to have access to a comprehensive evaluation of the crucial laser parameters. In this paper we present new information on the mechanisms that impact the pumping efficiency (concentration quenching and Auger upconversion) and the extraction process ( 4 I 11/2 terminal level lifetime and hole burning). Most of our results concern phosphate glasses, although fluorides and silicates are addressed as well. The relevant processes are illustrated in Fig. 1.
Evaluating Carpet Appearance Loss: Color Change (1994)

Changes in the appearance of carpet pile due to mechanical wear are usually ac companied by changes in apparent color. This paper describes the application of color image analysis to measurements of color variations. We characterize color by converting digitized RGB into HSV, XYZ, and L*a*b* systems. While color appears to change in some of the carpets we evaluated, color change is always accompanied by a cor responding change in brightness or gray level.
ChemInform Abstract: A Chemistry and Material Perspective on Lithium Redox Flow Batteries Towards High‐Density Electrical Energy Storage (2015)

Abstract Review: 281 refs.
Oral Delivery of the P2Y12Receptor Antagonist Ticagrelor Prevents Loss of Photoreceptors in an ABCA4−/−Mouse Model of Retinal Degeneration (2019)

Oral treatment with ticagrelor protected photoreceptors in the ABCA4-/- mouse, which is consistent with enhanced lysosomal function. As mouse ticagrelor exposure levels were clinically relevant, the drug may be of benefit in preventing the loss of photoreceptors in Stargardt's disease and other neurodegenerations associated with lysosomal dysfunction.
Two Valence Bond State Model for Molecular Nonlinear Optical Properties. Nonequilibrium Solvation Formulation (1998)

The two valence bond state model frequently used to describe the nonlinear optical properties of push−pull polyenes and the effect of the bond length alternation (BLA) coordinate is generalized to include the effects of nonequilibrium solvation. It is shown how a polar solvent modifies, via the diabatic gap between the valence bond free energy surfaces, the character of the electronically adiabatic ground state and consequently the BLA and the (hyper)polarizabilities. The parameters characterizing a molecule in the model can be readily extracted from experimental measurements. The model is applied to the calculation of (hyper)polarizabilities for several molecules as a function of solvent polarity, and comparison is made with both experimental and previous theoretical results. Some directions for an improved description are discussed.
Novel InGaP/AlGaAs/InGaAs heterojunction FET for X-Ku band power applications (2002)

We have successfully fabricated a novel heterojunction FET (HJFET) with an InGaP surface layer for high yield X-Ku band power applications. Standard deviation in the threshold voltage of 60 mV was achieved by using a highly-selective wet recess etching technique. The fabricated HJFET (Wg=16.8 mm) delivered an output power of 9.5 W and a power-added efficiency of 35% with a low carrier-to-third-order intermodulation distortion ratio of -29.5 dBc at 12 GHz. Moreover, the 25.2 mm HJFET delivered an output power of 12.2 W.
Correction to Design and Synthesis of Orally Bioavailable Benzimidazole Reverse Amides as Pan RAF Kinase Inhibitors (2014)

[This corrects the article DOI: 10.1021/ml5002272.].
Lambada: Interactive Data Analytics on Cold Data Using Serverless Cloud Infrastructure [Poster] (2020)

The massive, instantaneous parallelism of serverless functions has created a lot of excitement for interactive batch applications. However, due to fundamental limitations of current offerings, there was no consensus yet as to whether or not this architecture is suitable for data processing. We present Lambada, a data analytics framework designed for serverless functions that overcomes the current limitations and simultaneously achieves better performance and lower cost than commercial alternatives.
In situ reactions for synthesis of composites, ceramics, and intermetallics (1995)

This symposium was held in Las Vegas, Nevada, during the 124th TMS Annual Meeting, February 12--16, 1995, and was co-sponsored by SMD and ASM-MSD, ASTM/TMS Composites and the TMS Powder Materials Committees. It was organized in five sessions: (1) Shock and Strain Related Effects, (2) In Situ Synthesis of Composites, (3) Combustion Synthesis and Densification, (4) In Situ Synthesis of Ceramic Systems, and (5) In Situ Synthesis of Intermetallic Systems. The papers presented in each of these sessions represent significant contributions on a wide variety of fundamental and technological aspects and bring together scientists, engineers, and manufacturers, both as speakers and audience. The authors deal with physical based mathematical models, theories, and simulations; mechanisms; thermodynamics; and kinetics of in situ reactions and their applications to the synthesis of composites, ceramics, and intermetallics. During the organization of this symposium, it became evident that while some authors welcomed the publication as limited peer reviewed symposium proceedings, others preferred publication as fully peer reviewed journal papers. Thus, this book contains the full text of approximately one-half of the papers presented at the symposium, as well as abstracts of all papers. It is expected that the full text of the remaining papers will be more » published in Metallurgical Transactions. Thirty two papers have been processed separately for inclusion of the data base. « less
Evaluierung der Nano-Partikel vermittelten Thermoablation in verschiedenen Geweben (2007)

Ziele: Den Effekt der magnetischen Thermoablation mittels supraparamagnetischer Nano-Partikel in verschiedenen tierischen Geweben ex-vivo zu vergleichen. Methode: 5 Proben mit einem Volumen von je 10 Mikroliter dreier Ferrofluide mit verschiedenen Eisenkonzentrationen (171mg/ml, 192mg/ml, 214mg/ml) wurden in Schweineleber, -niere und -muskulatur injiziert. Die Gewebeproben wurden anschließend für 5 Minuten in einer zirkulären Spule platziert mit deren Hilfe ein magnetisches Wechselfeld erzeugt wurde. Die Temperaturmessung während der induzierten Erhitzung erfolgte alle 15 Sekunden über eine fiberoptische Temperatursonde die über den Punktionstrakt der Injektionsnadel in den verschiedenen Gewebeproben platziert worden war. Nach der Exposition gegenüber dem magnetischen Wechselfeld wurden die Durchmesser der induzierten Koagulationsnekrosen gemessen und die Volumina berechnet. Anschließend wurden die Ergebnisse mittels T-Test auf signifikante Unterschiede hin untersucht. Ergebnis: In Muskulatur betrugen die Koagulationsvolumina 82±14mm3 (171mg/ml), 173±152mm3 (192mg/ml) und 228±158mm3 (214mg/ml). Die Nekrosen in Nierengewebe waren 79±30mm3 (171mg/ml), 135±79mm3 (192mg/ml) und 171±76mm3 (214mg/ml) groß. In Leber wurden Koagulationsvolumina von 96±41mm3 (171mg/ml), 192±53mm3 (192mg/ml) und 229±99mm3 (214mg/ml) gemessen. Die maximal erreichten Temperaturen betrugen 64,3±8,5°C in Muskulatur (192mg/ml), 64,0±6,8°C in Nierengewebe (214mg/ml) and 75,9±10,4°C in Lebergewebe (214mg/ml). Schlussfolgerung: Die Ergebnisse zeigen die prinzipielle Machbarkeit der magnetischen Thermoablation in verschiedenen Geweben. Hinsichtlich der erzielten Koagulationsvolumina zeigen zwischen Muskulatur, Nieren- und Lebergewebe keine statistisch signifikanten Unterschiede.
Allergic Airway Disease Prevents Lethal Synergy of Influenza A Virus-Streptococcus pneumoniae Coinfection (2019)

Fatal outcomes following influenza infection are often associated with secondary bacterial infections. Allergic airway disease (AAD) is known to influence severe complications from respiratory infections, and yet the mechanistic effect of AAD on influenza virus-<i>Streptococcus pneumoniae</i> coinfection has not been investigated previously. We examined the impact of AAD on host susceptibility to viral-bacterial coinfections. We report that AAD improved survival during coinfection when viral-bacterial challenge occurred 1 week after AAD. Counterintuitively, mice with AAD had significantly deceased proinflammatory responses during infection. Specifically, both CD4<sup>+</sup> and CD8<sup>+</sup> T cell interferon gamma (IFN-γ) responses were suppressed following AAD. Resistance to coinfection was also associated with strong transforming growth factor β1 (TGF-β1) expression and increased bacterial clearance. Treatment of AAD mice with IFN-γ or genetic deletion of TGF-β receptor II expression reversed the protective effects of AAD. Using a novel triple-challenge model system, we show for the first time that AAD can provide protection against influenza virus-<i>S. pneumoniae</i> coinfection through the production of TGF-β that suppresses the influenza virus-induced IFN-γ response, thereby preserving antibacterial immunity.<b>IMPORTANCE</b> Asthma has become one of the most common chronic diseases and has been identified as a risk factor for developing influenza. However, the impact of asthma on postinfluenza secondary bacterial infection is currently not known. Here, we developed a novel triple-challenge model of allergic airway disease, primary influenza infection, and secondary <i>Streptococcus pneumoniae</i> infection to investigate the impact of asthma on susceptibility to viral-bacterial coinfections. We report for the first time that mice recovering from acute allergic airway disease are highly resistant to influenza-pneumococcal coinfection and that this resistance is due to inhibition of influenza virus-mediated impairment of bacterial clearance. Further characterization of allergic airway disease-associated resistance against postinfluenza secondary bacterial infection may aid in the development of prophylactic and/or therapeutic treatment against coinfection.
Amicitia y relaciones clientelares durante el Bellum Hispaniense (2010)

Las relaciones de amicitia y clientela pompeyanas y cesarianas durante el Bellum Hispaniense confirman cómo son éstas las que definen en última instancia los modelos de gestión política y territorial en la península Ibérica.This paper aims to show how friendship relations and the Pompeian and Caesarian clientelae shaped the political and territorial organization in the Iberian Peninsula during the Bellum Hispaniense.
An evaluation of different setups for simulating lighting characteristics (2012)

The advance of technology continuously enables new luminaire designs and concepts. Evaluating such designs has traditionally been done using actual prototypes, in a real environment. The iterations needed to build, verify, and improve luminaire designs incur substantial costs and slow down the design process. A more attractive way is to evaluate designs using simulations, as they can be made cheaper and quicker for a wider variety of prototypes. However, the value of such simulations is determined by how closely they predict the outcome of actual perception experiments. In this paper, we discuss an actual perception experiment including several lighting settings in a normal office environment. The same office environment also has been modeled using different software tools, and photo-realistic renderings have been created of these models. These renderings were subsequently processed using various tonemapping operators in preparation for display. The total imaging chain can be considered a simulation setup, and we have executed several perception experiments on different setups. Our real interest is in finding which imaging chain gives us the best result, or in other words, which of them yields the closest match between virtual and real experiment. To answer this question, first of all an answer has to be found to the question, "which simulation setup matches the real world best?" As there is no unique, widely accepted measure to describe the performance of a certain setup, we consider a number of options and discuss the reasoning behind them along with their advantages and disadvantages.
Development of silicon photonics products for telecom and datacom (2015)

We review the work performed in Silicon Photonics at TeraXion for telecom and datacom applications. Coherent receivers and intensity modulators along with system tests arc presented. A novel approach for low-loss coupling is also demonstrated.
Perfusion and cardioplegia (1994)

The focus of the reports reviewed in the last year has shifted to "outcomes," perhaps in response to the pressures of national health care reform. With regards to the extracorporeal circulation requisite for complex cardiac repair, emphasis is placed on anticoagulation management, blood use and its systemic effects, cognitive outcome after cardiac operations, and the requirement and effects of intra-aortic balloon pumping on weaning from bypass. Additionally, interest in the systemic effects of prolonged warm perfusion consequent to the novel myocardial management strategy of warm cardioplegia is evident. Advances in cardioplegia have shifted predominantly toward additives, with specific emphasis on modulating inflammation, enhancing the metabolic substrate, and limiting toxic oxygen free radical injury and the ischemia-induced accumulation of cations.