gebhart/patrepeval huggingface dataset:
HuC242-DM4, an antibody-maytansinoid conjugate with superior preclinical activity in human CanAg-positive tumor xenograft models in SCID mice (2005)

1429 Several anti-tumor antibody-maytansinoid conjugates, commonly called TAPs (tumor-activated prodrugs) are currently under clinical evaluation. In particular, cantuzumab mertansine (huC242-DM1), has been evaluated in three Phase I clinical trials (A.W. Tolcher et al., J Clin Oncol 2003, 21:211-22; P.R. Helft et al., Clin Cancer Res 2004, 10:4363-4368) using different dosing schedules to treat patients with tumors expressing the CanAg target antigen. The immunoconjugate could be safely administered at pharmacologically meaningful doses and evidence of anti-tumor activity was seen in several patients, which led to a recommendation for broad clinical development of the agent (A.W. Tolcher et al., J Clin Oncol 2003, 21:211-22). During the clinical evaluation, further advancement in the TAP technology led to the development of TAPs with disulfide-containing linkers with increased stability under physiological conditions. One of these new TAPs that demonstrated improved pharmacokinetic behavior and superior anti-tumor activity in murine test models is huC242-DM4, which contains the same antibody as cantuzumab mertansine and targets therefore the same CanAg-expressing tumors. HuC242-DM4 caused complete regressions in several tumor xenograft models even with single i.v. administration at doses far below its maximal tolerated dose (MTD). For example, treatment of SCID mice bearing measurable N87 human gastric tumor xenografts with a single dose of 3.4 mg/kg caused complete regression of the tumors, with significant tumor regression observed at a dose below 2 mg/kg. With a MTD in SCID mice of greater than 40 mg/kg when given as a single i.v. bolus injection, a therapeutic index of over 20 was achieved. HuC42-DM 4 was also curative in mice bearing human colon tumor xenografts of HT29 and COLO 205 cells, at doses that were non-toxic. The disulfide linkage of huC242-DM4 was approximately 2-fold more stable during circulation in mice than that of cantuzumab mertansine. While the huC242-DM4 conjugate demonstrated increased stability and efficacy in vivo compared to cantuzumab mertansine, preliminary acute toxicity studies suggest that the two conjugates have similar tolerability in normal mice. The resulting increased therapeutic window for huC242-DM4 provides a preclinical rationale for its clinical evaluation in patients with CanAg-positive tumors, such as colorectal, pancreatic, gastric, and esophageal carcinomas.
Anti‐β2‐glycoprotein I antibodies recognizing platelet factor 4–heparin complex in antiphospholipid syndrome in patient substantiated with mouse Model (2003)

The antiphospholipid syndrome is defined by the presence of antiphospholipid antibodies associated with arterial and/or venous thrombosis, and recurrent abortion accompanied often by thrombocytopenia. These antibodies are heterogeneous and react against phospholipid-binding proteins such as beta2-glycoprotein I (beta2GPI) and prothrombin. The recognition of anti-beta2-glycoprotein I (anti-beta2GPI) by platelet factor 4-heparin complex (PF4-Hc) has been previously evoked and partially confirmed by the present inhibition studies. Further, the anti-beta2-glycoprotein I antibodies were purified from a patient with primary antiphospholipid syndrome using Affi-gel-10-beta2GPI immunoaffinity chromatography. The purified anti-beta2GPI IgM as well as patient serum equally recognized PF4-Hc in ELISA mode. In order to substantiate this data and to better understand we studied an animal model using mouse active immunization with the purified human anti-beta2GPI. The mice showed a significant decrease in their platelet count. In addition the ELISA responses of the immunized mice sera were positive against both beta2GPI and PF4-Hc, substantiating the double recognition. Despite many previous reported animal model studies, this is the first time we have shown the specific recognition of anti-beta2GPI antibodies by PF4-Hc, the results in the induced mice correlating the data observed with some patients.
PRELIMINARY USE OF NONINVASIVE, NIRS-MEASURED TISSUE PERFUSION IN CRITICALLY ILL PATIENTS. (2005)

Wu, Jacqueline; Soyemi, Olusola; Walz, Matthias; Yang, Ye; Soller, Babs; Mullen, Marie Author Information
Glucocorticoids promote the proliferation and antagonize the retinoic acid–mediated growth suppression of Epstein-Barr virus–immortalized B lymphocytes (2000)

Glucocorticoids are able to release Epstein-Barr virus-immortalized (EBV-immortalized) lymphoblastoid B cell lines (LCLs) from the persistent growth arrest induced in these cells by retinoic acid (RA). Moreover, physiologic concentrations of glucocorticoids efficiently antagonized LCL growth inhibition induced by 13-cis-RA; 9-cis-RA; all-trans-RA; and Ro 40-6055, an RA alpha receptor (RAR alpha) selective agonist. RAR alpha expression levels, however, were not affected by glucocorticoids. Glucocorticoids, but not other steroid hormones, directly promote LCL proliferation, a phenomenon that was mainly mediated by down-regulation of the cyclin-dependent kinase (CDK) inhibitor p27(Kip-1). Moreover, glucocorticoids contrasted the up-regulation of p27(Kip-1), which was underlying the RA-induced LCL growth arrest, thereby indicating that glucocorticoids and RA signalings probably converge on p27(Kip-1). Both antagonism of RA-mediated growth inhibition and promotion of LCL proliferation were efficiently reversed by the glucocorticoid receptor (GR) antagonist RU486, indicating that all of these effects were mediated by GR. Of note, RU486 also proved to be effective in vivo and, in mice, was able to significantly inhibit the growth of untreated LCLs as well as LCLs growth-arrested by RA in vitro. These findings provide a rational background to further evaluate the possible role of glucocorticoids in the pathogenesis of EBV-related lymphoproliferations of immunosuppressed patients. Moreover, GR antagonists deserve further consideration for their possible efficacy in the management of these disorders, and the use of schedules, including both RA and a GR antagonist, may allow a more thorough evaluation of the therapeutic potential of RA in this setting. (Blood. 2000;96:711-718)
2<sup>nd</sup> workshop on open resilient human-aware cyber-physical systems (2013)

Cyber-physical systems (CPS) are tight integrations of computation, networking, and physical objects. Recent advances in pervasive and ubiquitous information processing, driven by major breakthroughs in cyber-physical technology are paving the way towards a more hospitable and sustainable future via a more efficient management of our environment: homes, work places, open areas, etc. Examples of relevant applications include: future automotive and transportation systems featuring intensive sensing and open data communication devices, robot-assisted communication and cooperation in search and rescue missions, enhanced situation awareness in public urban spaces, assistance and monitoring in everyday life for elderly or handicapped people, smart resilient and secure heterogeneous energy grids, etc.
Crystallisation of nematic liquid crystal mixtures (2009)

In this paper, we propose a method to accelerate the crystallisation of nematic liquid crystal mixtures based on crystallisation theory. This method is to hold a nematic liquid crystal sample at a temperature suitable for crystal growth after aging it at a temperature suitable for nucleation. After we specified these temperatures of a nematic liquid crystal mixture using differential scanning calorimetry, we demonstrate that the two-temperature aging method is effective for the crystallisation of other nematic liquid crystal mixtures in which the crystal-liquid crystal transition temperature has so far been undetectable.
Bilayer Metal-Oxide CBRAM Technology for Improved Window Margin and Reliability (2015)

In this paper, a detailed reliability analysis of metal-oxide CBRAM devices is presented. We demonstrated that the addition of a thin metal-oxide layer in the bottom of the memory stack significantly increases the ROFF and the memory window (more than 1 decade), with improved endurance performance. At the same time, high thermal stability was also achieved (window margin constant during more than 24 hours at 250°C). The origin of the window margin degradation during endurance is discussed and interpreted by means of a Trap Assisted Tunneling Model, putting in evidence the role of defect generation and Cu residual atoms in the resistive layer.
Proceedings of the 15th International Conference on emerging Networking EXperiments and Technologies (2019)

It is our great pleasure to welcome you to the 8th International Conference on emerging Networking EXperiments and Technologies (CoNEXT'12). CoNEXT started in 2005 and has now grown into one the premier venues, sponsored by ACM SIGCOMM, for the dissemination of cutting-edge research in all areas of networking. We are both thankful for the opportunity to Chair the Technical Program Committee for the conference.

Here are a few facts and figures for this year's CoNEXT program. We received a record submission of 176 papers, representing an increase of 10% over 2011. For the first time, CoNEXT will have a full 3-day program: these encouraging signs reflect the vibrant activity in our community. A highly skilled and dedicated technical program committee (TPC) of 53 researchers from academia and industry selected the papers to be included in the technical program, after a thorough reviewing process. Five papers were early rejected, because they were out of scope or did not conform to the submission guidelines. During the first round of the review process, each of the 171 papers received three reviews. The resulting 99 most competitive submissions received two additional reviews during a second round (some papers received additional reviews when the consensus among the five reviewers indicated the need for additional input). This second round was followed by an extensive on-line discussion phase over a couple of weeks, after which 59 papers were chosen to be discussed for inclusion in the final program at the TPC meeting, held at the Shannon Laboratory at AT&T Labs-Research in Florham Park, NJ on September 15, 2012. This 9-hour meeting was attended in person by 34 TPC members (other TPC members participated by phone) and resulted in 31 accepted papers that will be presented as part of this year's three-day conference in Nice. Paper notifications and reviews were emailed within hours of the end of the TPC meeting. Every paper was shepherded by a TPC member, to help authors improve the paper and incorporate the useful suggestions for improvement from the TPC.
Supplementary Fig. S2 from Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models (2023)

Supplementary Fig. S2 from Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models
Single sensor three-phase permanent magnet synchronous motor drive based on Luenberger style-observers (2012)

This paper presents a technique to estimate phase currents and rotor position in a vector-controlled PMSM drive using only dc-link current measurement. Three cascaded Luenberger style observers were used to perform this task. The first one estimates phase currents and motor back emf while the other two observers estimate the rotor position and velocity. The estimated signals were compared to the actual ones and their effects on the drive performance were reported.
Small Molecule Host Materials for Solution Processed Phosphorescent Organic Light‐Emitting Diodes (2014)

Solution processed phosphorescent organic light-emitting diodes (OLEDs) have been actively developed due to merits of high quantum efficiency of phosphorescent materials and simple fabrication processes of solution processed OLEDs. The device performances of the solution processed phosphorescent OLEDs have been greatly improved in the last 10 years and the progress of the device performances was made by the development of small molecule host materials for solution processes. A hybrid host of polymer and small molecules, a single small molecule host and a mixed host of small molecule hosts have effectively enhanced the quantum efficiency of the solution processed phosphorescent OLEDs. Therefore, this paper reviews recent developments in small molecule host materials for solution processed phosphorescent OLEDs and provides future directions for the development of the small molecule host materials.
Estimating cell specific oxygen uptake and carbon dioxide production rates for mammalian cells in perfusion culture (2011)

We present robust methods for online estimation of cell specific oxygen uptake and carbon dioxide production rates (q(O2) and q(CO2), respectively) during perfusion cultivation of mammalian cells. Perfusion system gas and liquid phase mass balance expressions for oxygen and carbon dioxide were used to estimate q(O2), q(CO2) and the respiratory quotient (RQ) for Chinese hamster ovary (CHO) cells in perfusion culture over 12 steady states with varying dissolved oxygen (DO), pH, and temperature set points. Under standard conditions (DO = 50%, pH = 6.8, T = 36.5°C), q(O2) and q(CO2) ranges were 5.14-5.77 and 5.31-6.36 pmol/cell day, respectively, resulting in RQ values of 0.98-1.14. Changes to DO had a slight reducing effect on respiration rates with q(O2) and q(CO2) values of 4.64 and 5.47, respectively, at DO = 20% and 4.57 and 5.12 at DO = 100%. Respiration rates were lower at low pH with q(O2) and q(CO2) values of 4.07 and 4.15 pmol/cell day at pH = 6.6 and 4.98 and 5.36 pmol/cell day at pH = 7. Temperature also impacted respiration rates with respective q(O2) and q(CO2) values of 3.97 and 4.02 pmol/cell day at 30.5°C and 5.53 and 6.25 pmol/cell day at 37.5°C. Despite these changes in q(O2) and q(CO2) values, the RQ values in this study ranged from 0.98 to 1.23 suggesting that RQ was close to unity. Real-time q(O2) and q(CO2) estimates obtained using the approach presented in this study provide additional quantitative information on cell physiology both during bioprocess development and commercial biotherapeutic manufacturing.
Patterning linear and nonlinear optical properties of photosensitive glasses by femtosecond structured light (2015)

We report on structured light-induced femtosecond direct laser writing (DLW) under tight focusing in non-commercial silver-containing zinc phosphate glass, which leads to original patterns of fluorescent silver clusters. These fluorescence topologies show unique features of frustrated diffusion of charged species, giving rise to distorted silver cluster spatial distributions. Fluorescence and second harmonic generation correlative microscopy demonstrate the realization of structured light-induced direct laser poling, resulting from a laser-induced permanent and stable electric field buried inside the modified glass. Thus, structured light-induced DLW remarkably enables both linear and nonlinear patterning. This work highlights the interest of optical phase engineering to obtain nontrivial beam profiles and subsequent photo-induced patterns that cannot be reached under Gaussian beam irradiation.
Chemoselektive Mehrkomponenten‐Synthese von α‐β‐ungesättigten Estern und Lactonen sowie deren Diels‐Alder‐Addukten (1985)

Die „Eintopfreaktion”︁ von Alkoholen 1 (auch chiralen), Aldehyden 2 und Ketenylidentriphenylphosphoran 3 ergibt α,β‐ungesättigte Ester 4 . Bei Verwendung von γ‐Hydroxyaldehyden resultieren makrocyclische α,β‐ungesättigte Lactone. Vierkomponenten‐Reaktionen zwischen 1,2,3 und einem Dien führen unmittelbar zu Diels‐Alder‐Addukten von 4 . magnified image
American Sign Language Alphabet Recognition Using Inertial Motion Capture System with Deep Learning (2022)

Sign language is designed as a natural communication method for the deaf community to convey messages and connect with society. In American sign language, twenty-six special sign gestures from the alphabet are used for the fingerspelling of proper words. The purpose of this research is to classify the hand gestures in the alphabet and recognize a sequence of gestures in the fingerspelling using an inertial hand motion capture system. In this work, time and time-frequency domain features and angle-based features are extracted from the raw data for classification with convolutional neural network-based classifiers. In fingerspelling recognition, we explore two kinds of models: connectionist temporal classification and encoder-decoder structured sequence recognition model. The study reveals that the classification model achieves an average accuracy of 74.8% for dynamic ASL gestures considering user independence. Moreover, the proposed two sequence recognition models achieve 55.1%, 93.4% accuracy in word-level evaluation, and 86.5%, 97.9% in the letter-level evaluation of fingerspelling. The proposed method has the potential to recognize more hand gestures of sign language with highly reliable inertial data from the device.
H2S Suppression During the Desulfation of a Lean NOx Trap with a Nickel-Containing Catalyst (2005)

&lt;div class="htmlview paragraph"&gt;Lean NO&lt;sub&gt;x&lt;/sub&gt; Traps are used to treat the NO&lt;sub&gt;x&lt;/sub&gt; emissions from lean-burn engines by storing the NO&lt;sub&gt;x&lt;/sub&gt; under lean conditions and reducing the NO&lt;sub&gt;x&lt;/sub&gt; during periodic rich excursions. However, sulfur poisons the adsorption sites of the traps. The sulfur can be removed from the NO&lt;sub&gt;x&lt;/sub&gt; trap by operating rich at high temperatures for several minutes. This results in the release of some SO&lt;sub&gt;2&lt;/sub&gt; but also large quantities of H&lt;sub&gt;2&lt;/sub&gt;S, which is a source of customer dissatisfaction that must be reduced or eliminated. This paper describes the use of a nickel-containing catalyst and air/fuel control to maximize the release of SO&lt;sub&gt;2&lt;/sub&gt; and minimize the emissions of H&lt;sub&gt;2&lt;/sub&gt;S during the desulfation of a lean NO&lt;sub&gt;x&lt;/sub&gt; trap. We present laboratory and vehicle data with a nickel-containing catalyst located downstream of a lean NO&lt;sub&gt;x&lt;/sub&gt; trap during desulfations of the trap. The nickel effectively reduced the emissions of H&lt;sub&gt;2&lt;/sub&gt;S during the desulfation while improving the robustness to fluctuations in the air/fuel control.&lt;/div&gt;
On the performance of signal detection algorithms in flat-fading and frequency-selective MIMO channels (2003)

In this work, we study a single-user MIMO transmission link in flat and frequency selective Rayleigh fading. The impact of the time dispersion in the channel on the performance of the signal separation algorithms is analyzed. We discuss the mismatch case in which the receiver assumes a flat-fading channel but is confronted actually with a frequency-selective MIMO channel. We give an analytical formula for the uncoded bit error rate in the mismatch case for zero-forcing detection. It is shown how to generalize the well known signal detection algorithms for flat-fading MIMO channels to the frequency-selective case. In particular, the performance and complexity of these algorithms is compared. A suboptimal algorithm with reduced complexity is proposed and compared to the optimal algorithms. All theoretical results are confirmed by numerical simulations.
Experimental Demonstration of an Electrodynamic Transformer (2011)

This paper explores a passive, two-port electromechanical device that employs electrodynamic transduction to yield transformer-like electrical behavior. The device-coined an “electrodynamic transformer” (ET)-comprises two coils that are coupled by their electrodynamic interaction with a strong, static magnet field, supplied by permanent magnets. A prototype structure is built and tested to explore the concept. Operating at 22 Hz, the proof-of-concept device provides a peak open-circuit voltage gain of 12, and a peak efficiency of 39%. The voltage gain is also electrically tunable within the range of ±5%.
A twenty eight-gene signature and survival in completely-resected non-small cell lung cancer (NSCLC) (2007)

10583 Background: Current staging methods are imprecise for predicting the outcome of treatment of non-small-cell lung cancer (NSCLC). We have developed a 28-gene signature that is closely associated with recurrence-free and overall survival. Methods: We used whole-genome gene expression microarrays to analyze frozen-tumor samples from 174 patients (pT1&amp;2, N0&amp;1, MO), who had undergone complete surgical resection in 5 European institutions. Randomly generated numbers were used to assign 2/3 of the samples to an algorithm training group with the remaining 1/3 set aside for independent validation. Cox proportional hazards models were used to evaluate the association between the level of expression and patient survival. We used risk scores and nearest centroid analysis to develop a gene-expression model for the prediction of treatment outcome. Leave-one-out cross validation was used to prevent model over-training. Results: 28 genes that correlated with survival were identified by analyzing microarray data and risk scores. Based on the expression of these genes, patients in training and validation groups were classified as either high (48%) or low (52%) risk. Analysis of predicted risk groups revealed significantly different survival distributions for patients in both the training set (p&lt;0.001) and independent validation set (p=0.006). Genes in our prognostic signature encode for several membrane-bound proteins with previously demonstrated involvement in cell cycle regulation and cell proliferation processes. Conclusions: Our 28-gene signature is closely associated with time to recurrence and overall survival of completely-resected NSCLC patients. [Table: see text]
Molecular Dynamics Simulations of Polyelectrolyte Solutions:  Osmotic Coefficient and Counterion Condensation (2003)

Osmotic coefficients and counterion distribution functions of rodlike and flexible polyelectrolyte chains have been studied using molecular dynamics simulations of multichain systems with explicit counterions in salt-free solutions. Using the counterion density profile, we have verified different regimes in the phase diagram of rodlike and flexible chains predicted by the two-zone model of Deshkovski et al. The agreement between our simulation results and predictions of the two-zone model is reasonably good for weakly charged rodlike chains. However, for flexible chains our results for the distance dependence of the counterion density profile in different regions of the phase diagram are only in qualitative agreement with the predictions of the two-zone model. The osmotic coefficient changes nonmonotonically with polymer concentration, in agreement with predictions of the two-zone model. The osmotic coefficient decreases with increasing polymer concentration in dilute solutions of both rodlike and flexible polyelectrolytes. In semidilute solutions of flexible chains the osmotic coefficient is an increasing function of polymer concentration. We have found that position of the minimum in the osmotic coefficient is close to the overlap concentration.
Histologically Proven Bronchial Neuroendocrine Tumors in MEN1: A GTE 51‐Case Cohort Study (2017)

Around 5% of MEN1 patients develop br-NETs. br-NETs do not decrease overall survival in MEN1 patients, but poorly differentiated and aggressive br-NETs can cause death. br-NETs must be screened carefully. A biopsy is essential to operate on patients in time.
Supplementary Figure 1 from Pancreatic Ductal Adenocarcinoma Subtyping Using the Biomarkers Hepatocyte Nuclear Factor-1A and Cytokeratin-81 Correlates with Outcome and Treatment Response (2023)

&lt;p&gt;Frequency distributions of IHC-derived subtypes of PDAC and unclassifiable cases (purple) in all cohorts investigated in this study.&lt;/p&gt;
A modern perspective on the earliest description of an intraneural ganglion cyst arising from the knee joint (2010)

A modern perspective on the earliest description of an intraneural ganglion cyst arising from the knee joint