gebhart/patrepeval huggingface dataset:
Glomerular responses to platelet-activating factor in the rat: role of thromboxane A2 (1989)

In view of its role as a pro-inflammatory mediator in glomerular injury, we investigated the renal cortical microcirculatory responses to the intrarenal arterial administration of platelet-activating factor (PAF) in the anesthetized euvolemic Munich-Wistar rat. Close arterial administration of PAF led to dose-dependent reductions in renal plasma flow rate (RPF), glomerular filtration rate (GFR), and filtration fraction (FF), in the absence of hypotension or hemoconcentration. Single-nephron (SN) plasma flow rate (QA), SNGFR and SNFF also fell [126 +/- 7 to 101 +/- 6 nl/min (P less than 0.005), 40.6 +/- 2.1 to 21.5 +/- 2.5 nl/min (P less than 0.005), and 0.33 +/- 0.03 to 0.21 +/- 0.03 (P less than 0.025)]. PAF increased pre- and postglomerular arteriolar resistances [2.32 +/- 0.14 to 2.73 +/- 0.19 (P less than 0.005) and 1.32 +/- 0.13 to 1.45 +/- 0.10(10)dyn.s.cm-5 (P less than 0.05)]. PAF infusion also led to a dramatic reduction in the mean value for the glomerular capillary ultrafiltration coefficient, Kf [0.058 +/- 0.012 to 0.020 +/- 0.003 nl.s-1.mmHg (P less than 0.025)]. PAF-induced changes in renal hemodynamics were abolished in the presence of the cyclooxygenase inhibitors, indomethacin and ibuprofen. When administered concomitantly with a thromboxane A2 (TxA2) receptor antagonist, PAF led to significant increases in RPF and GFR. In isolated glomeruli, PAF stimulated the biosynthesis of TxB2 in a dose-dependent manner. Thus PAF depresses rat glomerular function by inducing contraction of arteriolar and mesangial smooth muscle. These effects are likely mediated via the secondary release of TxA2.
KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo (2008)

Histone deacetylase (HDAC) inhibitors have garnered significant attention as cancer drugs. These therapeutic agents have recently been clinically validated with the market approval of vorinostat (SAHA, Zolinza) for treatment of cutaneous T-cell lymphoma. Like vorinostat, most of the small-molecule HDAC inhibitors in clinical development are hydroxamic acids, whose inhibitory activity stems from their ability to coordinate the catalytic Zn2+ in the active site of HDACs. We sought to identify novel, nonhydroxamate-based HDAC inhibitors with potentially distinct pharmaceutical properties via an ultra-high throughput small molecule biochemical screen against the HDAC activity in a HeLa cell nuclear extract. An alpha-mercaptoketone series was identified and chemically optimized. The lead compound, KD5170, exhibits HDAC inhibitory activity with an IC50 of 0.045 micromol/L in the screening biochemical assay and an EC50 of 0.025 micromol/L in HeLa cell-based assays that monitor histone H3 acetylation. KD5170 also exhibits broad spectrum classes I and II HDAC inhibition in assays using purified recombinant human isoforms. KD5170 shows significant antiproliferative activity against a variety of human tumor cell lines, including the NCI-60 panel. Significant tumor growth inhibition was observed after p.o. dosing in human HCT-116 (colorectal cancer), NCI-H460 (non-small cell lung carcinoma), and PC-3 (prostate cancer) s.c. xenografts in nude mice. In addition, a significant increase in antitumor activity and time to end-point occurred when KD5170 was combined with docetaxel in xenografts of the PC-3 prostate cancer cell line. The biological and pharmaceutical profile of KD5170 supports its continued preclinical and clinical development as a broad spectrum anticancer agent.
WAMS based dynamic state estimator during power system transient process (2008)

Wide area measurement system (WAMS) has been widely used in power system dynamic monitoring and control, such as low frequency identification and control, stability analysis and control, etc. However, as a measurement tool, WAMS has the measurement error and bad data unavoidably. If the raw data is applied directly, the unpredictable consequence will be resulted in. Aiming at this problem, a novel dynamic state estimator for generator state variables is proposed in this paper. The mathematical model of the algorithm are described. The simulation results show that the proposed method can provide the estimated trajectories of the generators in real-time, which eliminates the impact of measurement error and bad data and gives the backbone for WAMS based dynamic applications and real-time control.
ChemInform Abstract: Biomimetic Formation of Macrocyclic Spermine Alkaloids. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Data from A Clinical PET Imaging Tracer ([<sup>18</sup>F]DASA-23) to Monitor Pyruvate Kinase M2–Induced Glycolytic Reprogramming in Glioblastoma (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Pyruvate kinase M2 (PKM2) catalyzes the final step in glycolysis, a key process of cancer metabolism. PKM2 is preferentially expressed by glioblastoma (GBM) cells with minimal expression in healthy brain. We describe the development, validation, and translation of a novel PET tracer to study PKM2 in GBM. We evaluated 1-((2-fluoro-6-[&lt;sup&gt;18&lt;/sup&gt;F]fluorophenyl)sulfonyl)-4-((4-methoxyphenyl)sulfonyl)piperazine ([&lt;sup&gt;18&lt;/sup&gt;F]DASA-23) in cell culture, mouse models of GBM, healthy human volunteers, and patients with GBM.&lt;/p&gt;Experimental Design:&lt;p&gt;[&lt;sup&gt;18&lt;/sup&gt;F]DASA-23 was synthesized with a molar activity of 100.47 ± 29.58 GBq/μmol and radiochemical purity &gt;95%. We performed initial testing of [&lt;sup&gt;18&lt;/sup&gt;F]DASA-23 in GBM cell culture and human GBM xenografts implanted orthotopically into mice. Next, we produced [&lt;sup&gt;18&lt;/sup&gt;F]DASA-23 under FDA oversight, and evaluated it in healthy volunteers and a pilot cohort of patients with glioma.&lt;/p&gt;Results:&lt;p&gt;In mouse imaging studies, [&lt;sup&gt;18&lt;/sup&gt;F]DASA-23 clearly delineated the U87 GBM from surrounding healthy brain tissue and had a tumor-to-brain ratio of 3.6 ± 0.5. In human volunteers, [&lt;sup&gt;18&lt;/sup&gt;F]DASA-23 crossed the intact blood–brain barrier and was rapidly cleared. In patients with GBM, [&lt;sup&gt;18&lt;/sup&gt;F]DASA-23 successfully outlined tumors visible on contrast-enhanced MRI. The uptake of [&lt;sup&gt;18&lt;/sup&gt;F]DASA-23 was markedly elevated in GBMs compared with normal brain, and it identified a metabolic nonresponder within 1 week of treatment initiation.&lt;/p&gt;Conclusions:&lt;p&gt;We developed and translated [&lt;sup&gt;18&lt;/sup&gt;F]DASA-23 as a new tracer that demonstrated the visualization of aberrantly expressed PKM2 for the first time in human subjects. These results warrant further clinical evaluation of [&lt;sup&gt;18&lt;/sup&gt;F]DASA-23 to assess its utility for imaging therapy–induced normalization of aberrant cancer metabolism.&lt;/p&gt;&lt;/div&gt;
Characterization of strains of Neisseria meningitidis recovered from complement-sufficient and complement-deficient patients in the Western Cape Province, South Africa (1994)

Complement deficiency has been associated with increased susceptibility to meningococcal disease. In order to determine whether special meningococcal strains caused disease in complement-deficient (CD) patients, 17 Neisseria meningitidis strains recovered from patients in the Western Cape Province, South Africa, known to be CD were compared with 124 routine isolates obtained from patients living in the same area. Serogrouping of the strains from the CD subjects revealed that the common serogroups, particularly serogroup B, predominated. However, the prevalence of rare serogroups among isolates from CD subjects was significantly higher than that found among isolates from the control group. Sero- and subtyping of the class 1 and class 2 or 3 outer membrane proteins showed no significant difference between isolates from CD subjects and the routine clinical isolates. Multilocus enzyme electrophoresis of the 141 isolates revealed six clusters of electrophoretic types (ETs) and two unrelated ETs. The same degree of genetic diversity existed in ETs of isolates from CD subjects and the control group. However, the ET-5 complex, which is known to be associated with epidemic disease, was found in 22 (18%) of the routine clinical isolates but in none of the isolates from the CD subjects. This difference was marginally significant. What was highly significant was the finding that 8 of the 17 isolates from CD subjects were in one ET cluster, cluster F, which comprised a total of 20 isolates. Thus, our results show a difference in the clonal compositions of the strains that infect CD subjects in comparison with the clonal compositions of those that cause clinical infections in the population at large.
Reduced resolution MPEG-2 to H.264 transcoder (2008)

This paper describes complexity reduction in MPEG-2 to H.264 transcoding with resolution reduction. The methods
developed are applicable to transcoding any DCT based video such as MPEG-2, MPEG-4, and H.263 to the recently
standardized H.264 video at a reduced resolution. H.264 is being adopted by mobile device industry and devices such as
iPod use H.264. The mobile devices, however, need the video at a reduced resolution. The proposed transcoder
accelerates the H.264 encoding stage by performing motion estimation for only one block size as determined by the
trained decision trees. Our solution allows conversion of MPEG-2 video to the H.264 video format at a reduced
resolution with substantially less computing complexity. We use machine learning based approaches to significantly
reduce the complexity of this transcoding. Experimental results show a reduction in transcoding time of about 67% (a 3x
speedup) with a less than -0.5 dB change in PSNR.
Loading short pulses into long lifetime cavities (2022)

We demonstrate the loading of very short optical pulses into a high-Q cavity with linewidth much narrower than the pulse frequency envelope. We show that loading into the cavity is significantly enhanced if the pulse is combined with a cw-field, thus altering the pulse frequency profile to better match the cavity profile.
PipPhos and MorfPhos: Privileged Monodentate Phosphoramidite Ligands for Rhodium‐Catalyzed Asymmetric Hydrogenation. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Parsimonious sound field synthesis using compressive sampling (2009)

Reproducing a sampled sound field over a two-dimensional area using an array of loudspeakers is a problem with well-appreciated applications to acoustics and ultrasound treatment. Loudspeaker signal design has traditionally relied on a (possibly regularized) least-squares criterion. The fresh look advocated here, permeates benefits from advances in variable selection and compressive sampling by casting the sound field synthesis as a sparse linear regression problem that is solved by the least absolute shrinkage and selection operator (Lasso). Analysis and simulations demonstrate that the novel approach exhibits superb performance even for under-sampled sound fields, where least-squares methods yield inconsistent field reproduction. In addition, Lasso-based synthesis enables judicious placement of parsimonious loudspeaker arrays.
Supplementary Data from Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer (2023)

&lt;p&gt;Supplementary Table 1&lt;/p&gt;
Textpresso - an Information Retrieval and Extraction System for Biological Literature. (2008)

We developed an information retrieval and extraction system that processes the full 
text of biological papers. The system, called Textpresso, separates text into 
sentences, labels words and phrases according to an ontology (an organized lexicon), 
and allows queries to be performed on a database of labeled sentences. The current 
ontology comprises approximately one hundred categories of terms, such as A¢â‚¬A“geneA¢â‚¬Â, 
A¢â‚¬A“regulationA¢â‚¬Â, A¢â‚¬A“human diseaseA¢â‚¬Â, A¢â‚¬A“brain areaA¢â‚¬Â etc., and also contains main Gene 
Ontology (GO) categories. Extraction of particular biological facts, such as gene-A‚Â­gene 
interactions, or the curation of GO cellular components, can be accelerated 
significantly by ontologies, with Textpresso automatically performing nearly as well as 
expert curators to identify sentences. Search engine for four literatures, C. elegans, 
Drosophila, Arabidopsis and Neuroscience have been established by us, and thirteen 
systems for other literatures have been developed by other groups around the world. 
Currently, our four systems contain 112,000 papers with 40 million sentences, all 
systems worldwide contain 190,000 papers with approximately 65 million sentences.
Highly organosoluble and flexible polyimides with color lightness and transparency based on 2,2‐bis[4‐(2‐trifluoromethyl‐4‐aminophenoxy)‐3,5‐dimethylphenyl]propane (2004)

Abstract A new diamine containing isopropylidene, methyl substituted arylene ether, and trifluoromethyl groups, 2,2‐bis[4‐(2‐trifluoromethyl‐4‐aminophenoxy)‐3,5‐dimethylphenyl]propane (BTADP), was synthesized and used in preparation of a series of polyimides by direct polycondensation with various aromatic tetracarboxylic dianhydrides in N , N ‐dimethylacetamide (DMAc). All polymers derived from diamine (BTADP) with trifluoromethyl substituents were highly organosoluble in the solvents, like N ‐methyl‐2‐pyrrolidinone (NMP), N , N ‐dimethylacetamide, N , N ‐dimethylformamide (DMF), pyridine, chloroform, tetrahydrofuran (THF), dimethyl sulfoxide (DMSO), dichloromethane, cyclohexanone, and γ‐butyrolactone at room temperature or upon heating at 70 °C. Inherent viscosities of the polyimides were found to range between 0.58 and 0.97 dL·g −1 . These polyimides had glass transition temperatures between 256 and 307 °C, and their 10% mass loss temperatures ranged from 440 to 462 °C and 421 to 443 °C under nitrogen and air, respectively. These polyimides had low dielectric constants in the range of 2.84–3.09. All the polyimides could be cast into films from DMAc solutions and were thermally converted into color lightness, optically transparent, flexible, and tough polyimides. The polyimide films had a tensile strength in the range of 83–97 MPa and a tensile modulus in the range of 2.0–2.2 GPa. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 5766–5774, 2004
Robotic mapping and monitoring of data centers (2011)

We describe an inexpensive autonomous robot capable of navigating previously unseen data centers and monitoring key metrics such as air temperature. The robot provides real-time navigation and sensor data to commercial IBM software, thereby enabling real-time generation of the data center layout, a thermal map and other visualizations of energy dynamics. Once it has mapped a data center, the robot can efficiently monitor it for hot spots and other anomalies using intelligent sampling. We demonstrate the robot's effectiveness via experimental studies from two production data centers.
Enteroviruses and Type 1 Diabetes: Candidate Genes Linked With Innate Immune Response (2015)

In addition to HLA associated genetic predisposition, the role of exogenous factors in the development of type 1 diabetes (T1D) is well admitted. Since many decades, accumulating evidence strongly has supported an association between enteroviruses (EV) and T1D (Hober and Sauter, 2010). Moreover, the potential mechanisms underlying this enteroviral pathogenesis are getting better understood, and may also be linked to background susceptibility.
Bone marrow: ultrasmall superparamagnetic iron oxide for MR imaging. (1991)

An ultrasmall superparamagnetic iron oxide (USPIO) preparation was evaluated as a potential intravenous contrast agent for magnetic resonance (MR) imaging of bone marrow. One hour after administration of USPIO (40, 80, and 160 mumols of iron per kilogram body weight) in rats and rabbits, T1 and T2 relaxation times were, respectively, approximately 30%, 50%, and 65% lower than precontrast relaxation times. Maximum decrease in relaxation times of marrow occurred within 1-24 hours after intravenous administration; thereafter, relaxation times slowly returned to normal within 7 days. In vivo MR imaging of rabbits and rats confirmed that USPIO decreases signal intensity of red and yellow marrow. The decrease was most marked with gradient echo pulse sequences. An animal model of intramedullary tumor demonstrated the potential of USPIO to enable differentiation between tumor and normal red marrow. USPIO-enhanced MR imaging improves detection of smaller tumors and allows differentiation of tumor deposits from islands of hyperplastic or normal red marrow.
Blind Separation Of Time-Varying Signal Mixtures Using Sparseness And Zadeh''S Transform (2006)

Publication in the conference proceedings of EUSIPCO, Florence, Italy, 2006
Solid-Phase Parallel Synthesis of Phosphite Ligands (2008)

Various routes for the synthesis of polymer-bound phosphites and phosphoramidites have been investigated. In the presence of a suitable activator the supported phosphoramidites react cleanly with alcohols to give the corresponding monodentate phosphite ligands in solution. We have applied this novel solid-phase route in the parallel synthesis of several monodentate chiral and achiral phosphite ligands.
Supplementary Table 3 from Tumor Suppressor Functions of miR-133a in Colorectal Cancer (2023)

&lt;p&gt;PDF file - 49K, DNA sequences of primers used in the study.&lt;/p&gt;
Continuous wavelet representation ofGreen functions in layered media (1998)

A continuous wavelet analysis technique is applied in the spectral domain to efficiently represent the multiscale features of the spectral-domain Green functions in layered media. Numerical examples for a microstrip and a shielded microstrip are presented.
Blind Estimation of Large Carrier Frequency Offset in Wireless OFDM Systems (2007)

In this paper, a highly efficient blind band-edge filter-based technique is introduced for the estimation of carrier frequency offsets that are much larger than the subcarrier spacing in orthogonal-frequency-division-multiplexing (OFDM) systems. The proposed scheme is shown to have a high accuracy and an acquisition range that is much larger than the subcarrier spacing limitation inherent to other synchronization techniques. The performance of the proposed system as well as other well-referred techniques is assessed over additive white Gaussian noise and frequency-selective fading channels using different pulse shaping filters
The Blind Men and the Elephant as a Metaphor for Surface Analysis, as Applied to the Preparation and Analysis of New, Highly Stable Materials for Separations Science (2010)

Extended abstract of a paper presented at Microscopy and Microanalysis 2010 in Portland, Oregon, USA, August 1 – August 5, 2010.
Polymer microphotonics (2003)

We report on a polymer-based planar lightwave circuit platform that enables high levels of integration. The materials used represent the state of the art in optical polymers, and include properties such as ultra-low loss (0.1 dB/cm in single-mode waveguides at 1550 nm), widely tunable refractive index contrast (0-35%), and large thermo-optic coefficient (-3.2×10<sup>-4</sup>/&deg;C). The large index contrast values enable compact photonic microcircuits. The circuits are produced photolithographically, and can have a variety of inorganic materials integrated in them (e.g., by insertion in slots or by flip-chip mounting), resulting in a platform that can support functions that span the range of the building blocks needed in optical circuitry, while using the highest-performance material for each function. In this manuscript, we focus on the polymeric microcircuits, which provide interconnects, static routing elements such as couplers, taps, and multi/demultiplexers, as well as thermo-optically dynamic elements such as tunable couplers, switches, variable optical attenuators, and tunable notch filters. We demonstrate complex-functionality polymeric photonic microcircuits based on this technology, including fully reconfigurable optical add/drop multiplexing subsystems on a chip that perform channel switching, power monitoring, load balancing, and wavelength shuffling.
Learning to Generate with Memory (2016)

Memory units have been widely used to enrich the capabilities of deep networks on capturing long-term dependencies in reasoning and prediction tasks, but little investigation exists on deep generative models (DGMs) which are good at inferring high-level invariant representations from unlabeled data. This paper presents a deep generative model with a possibly large external memory and an attention mechanism to capture the local detail information that is often lost in the bottom-up abstraction process in representation learning. By adopting a smooth attention model, the whole network is trained end-to-end by optimizing a variational bound of data likelihood via auto-encoding variational Bayesian methods, where an asymmetric recognition network is learnt jointly to infer high-level invariant representations. The asymmetric architecture can reduce the competition between bottom-up invariant feature extraction and top-down generation of instance details. Our experiments on several datasets demonstrate that memory can significantly boost the performance of DGMs and even achieve state-of-the-art results on various tasks, including density estimation, image generation, and missing value imputation.