gebhart/patrepeval huggingface dataset:
[Function of the right ventricle in interauricular communication in adults]. (1988)

This study was designed prospectively to analyze the influence of age and operation on right ventricular function in atrial septal defect; 17 patients were studied by means of radionuclide studies performed immediately before and approximately 6 months (5,8 +/- 2,3) after surgery. The pulmonary/systemic flow ratio (Qp/Qs) was determined by first pass technique, and right ventricular ejection fraction and peak filling rate were determined by equilibrium ventriculography. In addition, all patients had preoperative catheterization. According to age, patients were divided in group I (less than 35 years) and group II (greater than or equal to 35 years). Preoperatively, patients in group I, in comparison to group II, had better ejection fraction (48 +/- 8 vs 36 +/- 7; p less than 0.01), and better peak filling rate (3.7 +/- 0.9 vs 2.6 +/- 0.7; p less than 0.01), while Qp/Qs were not significantly different (2.5 +/- 0.8 vs 3.0 +/- 1.6) and pulmonary vascular resistances were less elevated (69 +/- 32 vs157 +/- 95 dynes/sec/cm-5; p less than 0.01). After surgery, right ventricular function did not significatively change in relation to preoperative data in both groups (ejection fraction: 44 +/- 13 and 34 +/- 5, respectively; peak filling rate: 3.3 +/- 1.4 and 2.1 +/- 0.6). We conclude that in atrial septal defect indexes of systolic and diastolic right ventricular function deteriorate with age, these changes being associated with a slight increase in pulmonary vascular resistance without changes of Qp/Qs; right ventricular dysfunction does not tend to improve postoperatively.
GaP core / TiO2 shell nanowires for water splitting (2019)

National audience
Computational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swapping (2017)

Therapeutic and diagnostic applications of monoclonal antibodies often require careful selection of binders that recognize specific epitopes on the target molecule to exert a desired modulation of biological function. Here we present a proof-of-concept application for the rational design of an epitope-specific antibody binding with the target protein Keap1, by grafting pre-defined structural interaction patterns from the native binding partner protein, Nrf2, onto geometrically matched positions of a set of antibody scaffolds. The designed antibodies bind to Keap1 and block the Keap1-Nrf2 interaction in an epitope-specific way. One resulting antibody is further optimised to achieve low-nanomolar binding affinity by in silico redesign of the CDRH3 sequences. An X-ray co-crystal structure of one resulting design reveals that the actual binding orientation and interface with Keap1 is very close to the design model, despite an unexpected CDRH3 tilt and V<sub>H</sub>/V<sub>L</sub> interface deviation, which indicates that the modelling precision may be improved by taking into account simultaneous CDR loops conformation and V<sub>H</sub>/V<sub>L</sub> orientation optimisation upon antibody sequence change. Our study confirms that, given a pre-existing crystal structure of the target protein-protein interaction, hotspots grafting with CDR loop swapping is an attractive route to the rational design of an antibody targeting a pre-selected epitope.
Predicting the response of lead selenide thin film photoconductor in circuits with a series load resistor (2023)

We compared spectral response of a PbSe thin film photoconductor using FTIR with either a current or voltage preamplifier from 77K to 340K. The voltage preamplifier had a series load resistor; the current preamplifier did not. A photoconductor’s resistance changes with incident light, thus its measured response in terms of amps or volts per watt of incident light depends on the preamplifier circuit configuration. However, commercial descriptions of spectral response often only present data for a single circuit configuration. This leads to different “apparent” spectral response curves for different circuits with the same device. We investigated how accurately we could predict the response trend of a voltage preamplifier circuit or a current preamplifier circuit using dark resistance (Rdark) and light resistance (Rlight) measurements. We were able to predict the temperature at which maximum response occurs within ~25K, suggesting that this approach can be useful to predict the response of a PbSe photoconductor in various circuits with a limited set of measurements.
Evaluation of the fermentative capacity of an indigenous Hanseniaspora sp. strain isolated from Lebanese apples for cider production (2020)

The present work studied the fermentative potential and carbon metabolism of an indigenous yeast isolated from Lebanese apples for cider production. The indigenous yeast strain was isolated from a spontaneous fermented juice of the Lebanese apple variety 'Ace spur'. The sequencing of the Internal Transcribed Spacer (ITS) domain of rRNA identified the isolated yeast strain as a member of the Hanseniaspora genus. These results suggest an intragenomic ITS sequence heterogeneity in the isolated yeast strain specifically in its ITS1 domain. The different investigations on the yeast carbon metabolism revealed that the isolated yeast is 'Crabtree positive' and can produce and accumulate ethanol from the first hours of fermentation. Thus, our findings highlight the possibility of using the isolated indigenous Hanseniaspora strain as a sole fermentative agent during cider production.
High Power Semiconductor Disk Lasers (2006)

We present high-power emission from semiconductor disk lasers. By intra-cavity frequency-doubling of multi-Watt infra-red emission, more than 0.5W of blue and green have been generated. 200 mW have been achieved directly for red emitters.
Magnetic logic functionalities and scalability of thermally assisted MRAMs (2013)

On paper, MRAMs combine non volatility, high speed, moderate power consumption, infinite endurance and radiation hardness, all at low cost and easy to embed. Since its inception in the late 90's, however, and despite numerous promising announcements from laboratories, large corporations and start-ups, MRAM has failed to live to its expectations. Large volume applications are still to be seen, with only Toggle switching-based standalone products currently available, at 180nm technology node. The recent advent of spin transfer torque, however, has shed a new light on MRAM with the promises of much improved performances and greater scalability to very advanced technology node. As a consequence, MRAM is now viewed again as a credible replacement to existing technologies for applications where the combination of non-volatility, speed, low power and endurance is key.
S1 from PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models (2023)

&lt;p&gt;A figure showing the process of generating and using PDX models.&lt;/p&gt;
Ingénierie des joints de grain dans les alliages à base de Nickel (2009)

Une voie d’optimisation des alliages à base&#13;\n de Nickel est l'ingénierie des joints de grains. Cette méthode consiste à contrôler la&#13;\n distribution du type de joints de grains. Un mécanisme de formation de joints spéciaux&#13;\n par maclage multiple lors des recuits est proposé. Les distributions de joints de grains&#13;\n issues de simulations de la recristallisation par la méthode de Monte Carlo sont&#13;\n comparées à des distributions obtenues expérimentalement.
Real-time monitoring of magnetic nanoparticle-assisted nanoplastic agglomeration and separation from water (2022)

Superparamagnetic iron oxide nanoparticles are used as remediation agents against nanoplastic pollutants. Magnetic particle spectroscopy is utilized as an advanced characterization method and limits of the approach are highlighted.
Growth-rate induced epitaxial orientation of CeO2 on Al2O3(0001) (2009)

High-quality CeO2 films were grown on Al2O3(0001) substrates using oxygen plasma-assisted molecular beam epitaxy. The epitaxial orientation of the films is found to be CeO2(100) and CeO2(111) at low (&amp;lt;8 Å/min) and higher growth rates (&amp;gt;12 Å/min), respectively. CeO2(100) film grows as three-dimensional islands, while CeO2(111) film grows as two-dimensional layers. The CeO2(100) film exhibits better epitaxial quality compared to CeO2(111) film. However, the CeO2(100) film on Al2O3(0001) shows three in-plane domains at 30° to each other. While the epitaxial quality is attributed to the close match between oxygen sublattices of CeO2(100) and Al2O3(0001), the three in-plane domains in CeO2(100) are attributed to the threefold symmetry of the substrate. The relative stability of different epitaxial orientations of CeO2 films on Al2O3(0001) obtained from molecular dynamics simulations strongly supports the experimental observations.
Demonstration of a Nonstoquastic Hamiltonian in Coupled Superconducting Flux Qubits (2020)

Demonstration of a $n\phantom{\rule{0}{0ex}}o\phantom{\rule{0}{0ex}}n\phantom{\rule{0}{0ex}}s\phantom{\rule{0}{0ex}}t\phantom{\rule{0}{0ex}}o\phantom{\rule{0}{0ex}}q\phantom{\rule{0}{0ex}}u\phantom{\rule{0}{0ex}}a\phantom{\rule{0}{0ex}}s\phantom{\rule{0}{0ex}}t\phantom{\rule{0}{0ex}}i\phantom{\rule{0}{0ex}}c$ Hamiltonian---one for which there exists no local basis in which all off-diagonal elements are nonpositive---is an important step toward the development of quantum annealers that are more computationally powerful, or even universal. (This condition is tied to the ``sign problem'' in quantum Monte Carlo techniques.) This work presents the implementation of such a Hamiltonian by coupling two flux qubits both inductively and capacitively. The signature of nonstoquastic behavior is observed through destructive interference in quantum coherent oscillations. This result would seem to bear strong implications for scalable quantum computing.
A review of high-temperature adhesives (1981)

The development of high temperature adhesives and polyphenylquinoxalines (PPQ) is reported. Thermoplastic polyimides and linear PPQ adhesive are shown to have potential for bonding both metals and composite structures. A nadic terminated addition polyimide adhesive, LARC-13, and an acetylene terminated phenylquinoxaline (ATPQ) were developed. Both of the addition type adhesives are shown to be more readily processable than linear materials but less thermooxidatively stable and more brittle. It is found that the addition type adhesives are able to perform, at elevated temperatures up to 595 C where linear systems fail thermoplastically.
Derivatives of S‐9‐fluorenylmethyl‐L‐cysteine (1982)

The 9-fluorenylmethyl (Fm) group was examined with respect to its potential for blocking the sulfhydryl function. The S-Fm group is resistant to acids and to catalytic hydrogenation but is cleaved by ammonia in methanol or by organic bases, such as a 20% solution of piperidine in dimethylformamide. Synthesis of N-tert.-butyloxycarbonyl-S-9-fluorenylmethyl-L-cysteine p-nitrophenyl ester and of cysteinyl peptides protected with the S-Fm group are described.
Human Immunodeficiency Virus (HIV) Seroprevalence in Persons Attending STD Clinics in the United States, 1985–1987 (1989)

We reviewed published and unpublished studies on seroprevalence of HIV antibody in persons attending sexually transmitted disease (STD) clinics in the United States from 1985 through 1987. We identified 23 studies from 16 states; nine studies determined risk factors for HIV. Overall, 899 (4.2%) of the 21,352 clinic attendees were seropositive; the seroprevalence rate was higher for men (5.9%) than for women (1.7%). Clinic seroprevalence ranged from 0.5% to 15.2% (median, 3.5%), reflecting in part the proportion of all attendees who were homosexual or bisexual, intravenous-drug users (IVDUs), or heterosexual partners of bisexual men or IVDUs (median proportion, 21.8% for the nine sites with this information). Most HIV-seropositive persons were at recognized risk (median for the same nine studies, 85.3%). Homosexual/bisexual men had the highest seroprevalence (median, 32.2%), followed by heterosexual IVDUs (median, 3.6%). Heterosexuals who denied intravenous-drug use had a median rate of 0.9%, which strongly correlated with rates in IVDUs in the same clinics (r = 0.88). We conclude many STD clinic attendees are infected with HIV. Because AIDS is an STD and seroprevalence has been associated with other STDs, STD clinics are important sites for HIV surveillance and risk-reduction education.
Characterization of Escherichia Coli Strains Causing Urinary Tract Infections in Patients With Transposed Intestinal Segments (2003)

This study highlights that further steps must be taken to prevent and treat urinary tract infections in this susceptible group. Particular attention should be given to the treatment of persistent infections.
Anisotropic geodesics for live‐wire mesh segmentation (2014)

Abstract We present an interactive method for mesh segmentation that is inspired by the classical live‐wire interaction for image segmentation. The core contribution of the work is the definition and computation of wires on surfaces that are likely to lie at segment boundaries. We define wires as geodesics in a new tensor‐based anisotropic metric, which improves upon previous metrics in stability and feature‐awareness. We further introduce a simple but effective mesh embedding approach that allows geodesic paths in an anisotropic path to be computed efficiently using existing algorithms designed for Euclidean geodesics. Our tool is particularly suited for delineating segmentation boundaries that are aligned with features or curvature directions, and we demonstrate its use in creating artist‐guided segmentations.
Abstract 3775: Pharmacokinetic (PK) / pharmacodynamic (PD) and efficacy relationship of selective inhibitors of nuclear export (KPT-SINE) (2012)

Abstract Chromosomal Maintenance Protein 1/Exportin 1 (CRM1/XPO1) is a key nuclear export protein whose inhibition leads to the nuclear accumulation of Tumor Suppressor Proteins (TSPs) such as p53, FOXO, PTEN, pRB and I-κB. Small molecule, KPT-SINE that block CRM1-dependent nuclear export can force the nuclear retention of TSPs, thus render cancer cells more susceptible to apoptosis and more responsive to other chemotherapies. KPT-SINE display significant in vitro and in vivo activity over a broad range of tumor cell lines and xenografts. To optimize the design of future clinical trials, we developed a pharmacodynamics assay and tested it in cell lines, leukocytes in vitro and leukocytes from animal models. Methods: We used quantitative PCR and immunoblotting to study patterns of gene expression of CRM1, Macrophage Inhibitory Cytokine 1 (MIC1), p53 and p21 in human, mouse, rat and monkey leukocytes. The selection and the validation of the four PD markers included 1. In vitro studies where expression of PD markers was determined in tumor cell lines. 2. In vitro studies where expression of PD markers was determined in purified leukocytes. 3. In vivo studies where expression of PD markers was determined in leukocytes isolated from mice, rats and monkeys that were treated with KPT-SINE in pharmacokinetic studies. Drug levels were determined in the plasma of all animals. Results: KPT-SINE treatment at 75 mg/kg QDX5 each week for 4 weeks inhibited tumor growth by more than 80% in Molt-4, Z-138, Hep3b and U87 xenograft models. In separate PK and TK studies, expression levels of the four PD markers were investigated and were found to correlate well with KPT-SINE exposure and duration. In addition, we found that the full induction of those markers was p53-dependent. However, we also observed partial p53-independent induction of CRM1 and MIC1. PK analysis in treated rats and monkeys indicated that KPT-SINE plasma concentrations above 250 nM were sufficient to induce significant changes in the mRNA expression levels of the PD markers. Those concentrations were higher than the individual cytotoxicity indexes (EC50), of each of the above cancer cell lines, that we measured in vitro by cell proliferation assay. Conclusions: The results from our studies suggest that KPT-SINE display potent in vivo efficacy in various xenograft models. We were able to identify PD markers that correlated well with in vitro and in vivo levels of KPT-SINE. Further studies investigating CRM1, p53, p21 and MIC1 as biomarkers of target inhibition and response to KPT-SINE treatment are on-going. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3775. doi:1538-7445.AM2012-3775
Many Young Children with Autism Who Use Psychotropic Medication Do Not Receive Behavior Therapy: A Multisite Case-Control Study (2023)

Objectives: To explore how many pre-school aged children with autism spectrum disorder (ASD) used psychotropic medication, child and geographic factors associated with psychotropic medication use, and how many children who used psychotropic medication did or did not ever receive behavior therapy. Study design: Children 2-5 years of age were enrolled from 2012 to 2016 in a multisite case-control study designed to investigate the development and risk factors of ASD. Children with a positive ASD screen or ASD diagnosis upon enrollment were asked to complete a comprehensive evaluation to determine ASD status and developmental level. Caregivers completed a Services and Treatments Questionnaire and multiple self-administered questionnaires to determine child use of psychotropic medication, ever receipt of behavior therapy, and presence of co-occurring symptoms. Results: There were 763 children who were classified as ASD and had data collected on the Services and Treatments Questionnaire. Of those, 62 (8.1%) used psychotropic medication to treat behavioral symptoms and 28 (3.7%) were ≤3 years of age when medication was first started. Attention problems (aOR, 7.65; 95% CI, 3.41-16.1; P < .001) and study site (aOR, 2.62; 95% CI, 1.04-6.56; P = .04) were significantly associated with psychotropic medication use after controlling for maternal race/ethnicity. More than one-half (59.7%) of those who used psychotropic medication did not ever receive behavior therapy. Conclusions: Many preschool-aged children with ASD who use psychotropic medication do not receive behavior therapy. Pediatricians are an important resource for children and families and can help facilitate behavioral treatment for children with ASD and other disorders.
Analysis of Estimation Performance of Load-side Torque and Load-side Velocity Observers for Human Interaction Control Based on Torsion Torque Control (2018)

This paper proposes a back-forward drivable control based on torsion torque control (TTC) that achieves both back-forward drivability and vibration suppression for a two-inertia system. The proposed system combines the TTC that consists of I-P controller and velocity deviation feedback and a motor-side normalization compensator (MNC) to facilitate human-robot interactions. For the velocity deviation estimation, load-side torque observer (LTOB) and load-side velocity observer (LVOB) are evaluated on estimation performance. The better observer is applied to the TTC from the analysis results. The effectiveness of the proposed control system is verified by simulation and experimental results, and the vibration of the back-forward drivable response is considerably suppressed.
Emerging Nanotechnology for Integration of Nanostructures in Nanoelectronic Devices (2010)

This chapter focuses on two emerging nanotechnologies developed to fabricate, organize and integrate nanomaterials (nanodots, nanowires) in nanoelectronics devices. The first one uses the natural properties of diblock copolymers to create (i) a hexagonal lattice array of vertical PMMA cylinders in a polystyrene (PS) matrix, or (ii) an ordered array of horizontal PMMA cylinders in a PS matrix. These films are then used as deposition and/or etching masks to produce dense lattices of 20 nm diameter nanoparticles and nanowires with a density of around 1011 cm-2. The chapter presents examples of integration with an 8-inch wafer memory technology. The second technology is based on chemical vapor deposition (CVD) of basic nanomaterial building blocks for future microelectronics. The chapter focuses on CVD growth of silicon nanostructures using a fully compatible CMOS process. The resulting nano-objects are integrated in test devices and measured electrically. Controlled Vocabulary Terms chemical vapour deposition; nanoelectronics; polymerisation
Porosity, strength, and alteration – Towards a new volcano stability assessment tool using VNIR-SWIR reflectance spectroscopy (2022)

Volcano slope stability analysis is a critical component of volcanic hazard assessments and monitoring. However, traditional methods for assessing rock strength require physical samples of rock which may be difficult to obtain or characterize in bulk. Here, visible to shortwave infrared (350–2500 nm; VNIR–SWIR) reflected light spectroscopy on laboratory-tested rock samples from Ruapehu, Ohakuri, Whakaari, and Banks Peninsula (New Zealand), Merapi (Indonesia), Chaos Crags (USA), Styrian Basin (Austria) and La Soufrière de Guadeloupe (Eastern Caribbean) volcanoes was used to design a novel rapid chemometric-based method to estimate uniaxial compressive strength (UCS) and porosity. Our Partial Least Squares Regression models return moderate accuracies for both UCS and porosity, with R2 of 0.43–0.49 and Mean Absolute Percentage Error (MAPE) of 0.2–0.4. When laboratory-measured porosity is included with spectral data, UCS prediction reaches an R2 of 0.82 and MAPE of 0.11. Our models highlight that the observed changes in the UCS are coupled with subtle mineralogical changes due to hydrothermal alteration at wavelengths of 360–438, 532–597, 1405–1455, 2179–2272, 2332–2386, and 2460–2490 nm. These mineralogical changes include mineral replacement, precipitation hydrothermal alteration processes which impact the strength of volcanic rocks, such as mineral replacement, precipitation, and/or silicification. Our approach highlights that spectroscopy can provide a first order assessment of rock strength and/or porosity or be used to complement laboratory porosity-based predictive models. VNIR-SWIR spectroscopy therefore provides an accurate non-destructive way of assessing rock strength and alteration mineralogy, even from remote sensing platforms.
A Versatile Solid‐Phase Synthesis of N‐Linked Glycopeptides (1995)

A convergent synthesis not requiring sugar protecting groups yields N‐glycopeptides. The key step is the condensation of unprotected glycosylamines with resin‐bound peptides that have activated carboxyl groups in specified positions. Twenty‐three N‐linked glycopeptides such as 1 and 2 all derived from one peptide motif were obtained. This approach should facilitate generation of glycopeptide libraries.
1A-5 Coded-Signal Imaging Using High-Frequency Annular Arrays (2006)

High-frequency (i.e., > 15 MHz) ultrasound (HFU) permits fine-resolution imaging. However, the limited depth of field (DOF) and acoustic penetration depth of HFU waves limits its clinical use to the assessment of shallow diseases such as ocular or dermatological conditions. The aim of this study is to use modern annular array transducer technology and coded signals to improve DOF and penetration depth simultaneously. Two 17-MHz, five-element annular arrays with focal lengths of 18 mm and 31 mm and total apertures of 6 mm and 10 mm were custom made using a 25-mum thick copolymer membrane. For imaging, the annular arrays were excited by coded chirp signals that linearly spanned frequency ranges between 0 and 40 MHz. Images of a phantom consisting of seven regularly spaced 25-mum wires demonstrated that DOF can be improved by a factor of 3 and that signal-to-noise ratio (SNR) can increase by more than 24 dB with coded-excitation methodologies