gebhart/patrepeval huggingface dataset:
Inflammation Modulates Murine Venous Thrombosis Resolution In Vivo (2012)

Integrated fluorescence molecular-structural imaging demonstrates that the DVT-induced inflammatory response can be readily assessed in vivo and can inform the magnitude of thrombus resolution.
GaSb doping facilitates conduction band convergence and improves thermoelectric performance in n-type PbS (2023)

We improve n-type lead chalcogenides by adding GaSb to reduce lattice thermal conductivity and achieve conduction band convergence. This significantly enhances the thermoelectric performance of n-type PbS, making it comparable to its p-type counterpart.
Legume nodulation: successful symbiosis through short- and long-distance signalling (2006)

Nodulation in legumes provides a major conduit of available nitrogen into the biosphere. The development of nitrogen-fixing nodules results from a symbiotic interaction between soil bacteria, commonly called rhizobia, and legume plants. Molecular genetic analysis in both model and agriculturally important legume species has resulted in the identification of a variety of genes that are essential for the establishment, maintenance and regulation of this symbiosis. Autoregulation of nodulation (AON) is a major internal process by which nodule numbers are controlled through prior nodulation events. Characterisation of AON-deficient mutants has revealed a novel systemic signal transduction pathway controlled by a receptor-like kinase. This review reports our present level of understanding on the short- and long-distance signalling networks controlling early nodulation events and AON.
Azido/Tetrazole Tautomerism in 2‐Azidoadenine β‐D‐Pentofuranonucleoside Derivatives (2003)

Abstract The β‐ D ‐ribofuranoside derivative of 2‐azidoadenine and its 2′‐deoxy‐, 2′,3′‐dideoxy‐ and 2′,3′‐dideoxy‐2′,3′‐didehydro counterparts have been synthesized. All these compounds were obtained through the preparation of their 2‐chloro precursors. These were converted into their 2‐hydrazino derivatives, which upon treatment with sodium nitrate in acid medium gave the target nucleosides. The azido/tetrazole tautomerism observed in such nucleoside analogues was studied in detail. The compounds were also tested for their activity against HIV and HBV, but did not show significant antiviral effects. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2003)
PET IMAGING IN PATIENTS WITH BIOCHEMICAL FAILURE FOLLOWING TREATMENT FOR LOCALIZED PROSTATE CANCER (1998)

Seltzer, M. A.; Barbaric, Z.; Naitoh, J.; Silverman, D. H.S.; deKernion, J. B.; Belldegrun, A.; Rosen, P.; Phelps, M. E.; Hoh, C. K. Author Information
Physical reservoir computing based on spin torque oscillator with forced synchronization (2019)

We investigated physical reservoir computing (RC) using a vortex-type spin torque oscillator (STO) as a resource of nonlinear dynamics, which is essential for processing information in time-series data. Forced synchronization was used to suppress the thermal fluctuation of the oscillation trajectory of the STO. We examined the memory property of the STO dynamics, called short-term memory (STM), by using a virtual node technique. The STM capacity increased about twofold compared with that obtained without forced synchronization. The performance index for the nonlinear transformation of the STO also increased; it was evaluated in a parity-check task. The results prove that the synchronized STO has great potential for physical RC based on nanotechnology.
Polybutadiene content and microstructure in high impact polystyrene (1996)

The polybutadiene (PB) content and its microstructure in different grades of high impact polystyrene (HIPS) has been studied by various spectroscopic techniques. PB is characterized by deformation bands in FTIR spectroscopy at 994, 967, 912, and 729 cm−1. FT-Raman was used for higher constant resolution over the range of wave numbers. It provides reasonable signal to noise ratios in near IR excited Raman. Proton and 13C-NMR spectroscopy was utilized for the determination of polybutadiene content in HIPS and tacticity, and reactivity ratios. © 1996 John Wiley & Sons, Inc.
Computational photography and compressive holography (2010)

As lasers, photosensors, and computational imaging techniques improve, holography becomes an increasingly attractive approach for imaging applications largely reserved for photography. For the same illumination energy, we show that holography and photography have nearly identical noise performance. Because the coherent field is two dimensional outside of a source, there is ambiguity in inferring the three-dimensional structure of a source from the coherent field. Compressive holography overcomes this limitation by imposing sparsity constraints on the three-dimensional scatterer, which greatly reduces the number of possibilities allowing reliable inference of structure. We demonstrate the use of compressive holography to infer the three-dimensional structure of a scene comprising two toys.
Exome Sequencing of African-American Prostate Cancer Reveals Loss-of-Function ERF Mutations (2017)

African-American men have the highest incidence of and mortality from prostate cancer. Whether a biological basis exists for this disparity remains unclear. Exome sequencing (<i>n</i> = 102) and targeted validation (<i>n</i> = 90) of localized primary hormone-naïve prostate cancer in African-American men identified several gene mutations not previously observed in this context, including recurrent loss-of-function mutations in <i>ERF</i>, an ETS transcriptional repressor, in 5% of cases. Analysis of existing prostate cancer cohorts revealed <i>ERF</i> deletions in 3% of primary prostate cancers and mutations or deletions in <i>ERF</i> in 3% to 5% of lethal castration-resistant prostate cancers. Knockdown of <i>ERF</i> confers increased anchorage-independent growth and generates a gene expression signature associated with oncogenic ETS activation and androgen signaling. Together, these results suggest that <i>ERF</i> is a prostate cancer tumor-suppressor gene. More generally, our findings support the application of systematic cancer genomic characterization in settings of broader ancestral diversity to enhance discovery and, eventually, therapeutic applications.<b>Significance:</b> Systematic genomic sequencing of prostate cancer in African-American men revealed new insights into prostate cancer, including the identification of <i>ERF</i> as a prostate cancer gene; somatic copy-number alteration differences; and uncommon <i>PIK3CA</i> and <i>PTEN</i> alterations. This study highlights the importance of inclusion of underrepresented minorities in cancer sequencing studies. <i>Cancer Discov; 7(9); 973-83. ©2017 AACR.</i><i>This article is highlighted in the In This Issue feature, p. 920</i>.
Anisotropic nanomaterials: structure, growth, assembly, and functions (2011)

Comprehensive knowledge over the shape of nanomaterials is a critical factor in designing devices with desired functions. Due to this reason, systematic efforts have been made to synthesize materials of diverse shape in the nanoscale regime. Anisotropic nanomaterials are a class of materials in which their properties are direction-dependent and more than one structural parameter is needed to describe them. Their unique and fine-tuned physical and chemical properties make them ideal candidates for devising new applications. In addition, the assembly of ordered one-dimensional (1D), two-dimensional (2D), and three-dimensional (3D) arrays of anisotropic nanoparticles brings novel properties into the resulting system, which would be entirely different from the properties of individual nanoparticles. This review presents an overview of current research in the area of anisotropic nanomaterials in general and noble metal nanoparticles in particular. We begin with an introduction to the advancements in this area followed by general aspects of the growth of anisotropic nanoparticles. Then we describe several important synthetic protocols for making anisotropic nanomaterials, followed by a summary of their assemblies, and conclude with major applications.
Ultrafast imaging of blood flow dynamics in the myocardium (2012)

International audience
'North Sea' Progressive Myoclonus Epilepsy: Phenotype of Subjects with GOSR2 Mutation (PD4.008) (2013)

OBJECTIVE: To definitively describe the clinical and electroencephalographic features of progressive myoclonic epilepsy (PME) due to mutation of the GOSR2 gene.
Synthesis and Properties of Polyimides Containing Multiple Alkyl Side Chains (2007)

A series of diamine monomers, i.e., 2,2‘-bis{4-[3,4,5-tris(n-alkan-1-yloxy)benzoate]}-4,4‘-biphenyldiamines containing multiple alkyl side chains, were synthesized in which the length of the alkyl side chains was varied from 5 to 18 carbon atoms. Polyimides were prepared from the diamines and pyromellitic dianhydride (PMDA), 3,3‘4,4‘-biphenyltetracarboxylic dianhydride (BPDA), 2,2‘-dibromo-4,4‘,5,5‘-biphenyltetracarboxylic dianhydride (DBBPDA), and 2,2‘-bis(3,4-dicarboxyphenyl)hexafluoropropane dianhydride (6FDA), respectively, using a one-step method in 1,2-dichlorobenzene or 1-chloronaphthalene. Most of the polymers had good solubility in chlorinated solvents. Several copolyimides were prepared: BPDA, 2,2‘-bis(trifluoromethyl)benzidine (PFMB), and C14 and C16 diamines. The solubility of copolyimides was dramatically affected by different monomer addition sequences. The high-molecular-weight polyimides could be solution cast into flexible, tough films except for those based on PMDA. The side chains that contained at least 10 carbon atoms crystallized. The melting points of the crystalline regions increased as the length of the side chains increased. Variable-temperature (VT) solid state 13C nuclear magnetic resonance (NMR) showed that the polyimide containing C18 side chains crystallized at room temperature. A wide-angle X-ray diffraction (WAXD) study showed that the spacing between the main chains increased as the number of carbon atoms in the side chains increased. The diameter of aggregated backbones was 2.14 nm, indicating several polyimide main chains stacked each other to form supermolecular, nanoscale structures. Three polyimides and one copolyimide were used to prepare alignment layers. The films generated liquid crystal pretilt angles of 6, 9, 90, and 90°, respectively.
Building Blocks for n-Type Molecular and Polymeric Electronics. Perfluoroalkyl- versus Alkyl-Functionalized Oligothiophenes (nT; n = 2−6). Systematics of Thin Film Microstructure, Semiconductor Performance, and Modeling of Majority Charge Injection in Field-Effect Transistors (2004)

The solid-state properties and FET electrical behavior of several series of alpha,omega- and beta,beta'-fluorocarbon- and alkyl-substituted and unsubstituted oligothiophenes nTs (n = 2-6) are compared and contrasted. The thin films were grown by slow vacuum deposition over a range of substrate temperatures and/or by casting from solution and were investigated by X-ray diffraction and scanning electron microscopy. Our results indicate that vacuum deposition at 60-80 degrees C affords films with remarkably similar microstructures despite the extensive H --> F substitution. Trends in observed d spacing versus molecular core extension provide quantitative information on molecular orientation. Field-effect transistor measurements performed for all systems and having the same device structure, components, and fabrication conditions demonstrate that all nTs functionalized with fluorocarbon chains at the thiophene termini are n-type semiconductors, in contrast to the p-type activity of the remaining systems. One of these systems, alpha,omega-diperfluorohexyl-4T, exhibits a mobility of 0.22 cm2/(V s) and an Ion:Ioff ratio of 10(6), one of the highest so far reported for an n-type organic semiconductor. The effect of substitution regiochemistry on FET majority charge carrier was additionally studied, in the case of a 6T core, by shifting the fluorocarbon substituents from the terminal to the central thiophene units. Finally, we propose a simple theoretical model for electrode/organic interfacial carrier injection. The results suggest why modest substituent-induced changes in the injection barrier can produce working n-type materials.
Counterpropagating Pair of Superluminal Raman Lasers without Cross-Talks for Ultrasensitive Rotation Sensing (2020)

We have demonstrated a pair of counter-propagating superluminal Raman lasers without cross-talk, employing two different gain cells, each containing two isotopes of Rb, as a key step in realizing an ultrasensitive rotation sensor.
Melanoma Cells Treated with GGTI and IFN-γ Allow Murine Vaccination and Enhance Cytotoxic Response against Human Melanoma Cells (2010)

These data indicate that pharmacological treatment of melanoma cell lines with IFN-gamma and GGTI-298 stimulates their immunogenicity and could be a novel approach to produce tumor cells suitable for vaccination and for stimulation of anti-melanoma effector cells.
Engineering server-driven consistency for large scale dynamic Web services (2001)

Article Share on Engineering server-driven consistency for large scale dynamic Web services Authors: Jian Yin Department of Computer Sciences, University of Texas at Austin, yin, lorenzo Department of Computer Sciences, University of Texas at Austin, yin, lorenzoView Profile , Lorenzo Alvisi Department of Computer Sciences, University of Texas at Austin, yin, lorenzo Department of Computer Sciences, University of Texas at Austin, yin, lorenzoView Profile , Mike Dahlin Department of Computer Sciences, University of Texas at Austin, yin, lorenzo Department of Computer Sciences, University of Texas at Austin, yin, lorenzoView Profile , Arun Iyengar IBM T.J. Watson Research Center, P.O. Box 704, Yorktown Heights, NY IBM T.J. Watson Research Center, P.O. Box 704, Yorktown Heights, NYView Profile Authors Info & Claims WWW '01: Proceedings of the 10th international conference on World Wide WebMay 2001Pages 45–57https://doi.org/10.1145/371920.371935Published:01 April 2001Publication History 39citation822DownloadsMetricsTotal Citations39Total Downloads822Last 12 Months16Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Functional Characterization of a Recombinant FVIIa Drug Candidate (2010)

Abstract Abstract 4653 Human coagulation factor VII (FVII) is a vitamin-K-dependent protein with a molecular weight of 50 kDa. Activation of FVII occurs by cleavage of the arginine 152 – isoleucine 153 peptide bond resulting in two disulfide-linked peptide chains. The therapeutic utility of rFVIIa is based on its capacity to trigger hemostasis independently from factor VIII and factor IX and thus even in the presence of factor VIII or factor IX inhibitors. Baxter has developed a recombinant FVIIa (rFVIIa) that is synthesized by a genetically engineered Chinese hamster ovary (CHO) cell line. No materials of human or animal origin are employed in the manufacture, purification, or formulation of the final product, thus reducing the risk of transmission of adventitious agents. The growth medium is a chemically defined medium, and the downstream process does not use monoclonal antibodies for the purification of rFVIIa. The rFVIIa drug candidate was functionally characterized in vitro and its features were compared with those of a commercially available rFVIIa. The overall hemostatic potency of rFVIIa was assessed by its FVIII bypassing activity in a human FVIII-deficient plasma with high-titer inhibitor by measuring the kinetics of thrombin generation and fibrin formation. The thrombin-generating capacity of the rFVIIa drug candidate was similar to that of commercial rFVIIa. The time and rate of fibrin formation was measured by thromboelastography, where a dose-dependent normalization of the impaired clotting times and fibrin formation was observed. A similar FXa-generating potency was found for rFVIIa and commercial rFVIIa when measured on the surface of TF-expressing fibroblasts, suggesting a full capability to bind to TF-bearing cells and trigger hemostasis on their surfaces. rFVIIa could be inactivated by anti-thrombin III-heparin in solution with relipidated TF with no relevant difference to the comparator product. TF pathway inhibitor effectively inhibited FXa generation in a cell-based activity assay, with a similar IC50 for rFVIIa and the comparator. In summary, the functional characteristics of the rFVIIa drug candidate were very similar to those of commercially available rFVIIa. Disclosures: Turecek: Baxter Innovations GmbH: Employment. Varadi:Baxter Innovations GmbH: Employment. Vejda:Baxter Innovations GmbH: Employment. Boehm:Baxter Innovations GmbH: Employment. Rottensteiner:Baxter Innovations GmbH: Employment. Schwarz:Baxter Innovations GmbH: Employment. Reiter:Baxter Innovations GmbH: Employment. Mitterer:Baxter Innovations GmbH: Employment. Mundt:Baxter Innovations GmbH: Employment. Ehrlich:Baxter Innovations GmbH: Employment. Scheiflinger:Baxter Innovations GmbH: Employment.
Closing coronavirus spike glycoproteins by structure-guided design (2020)

The recent spillover of SARS-CoV-2 in the human population resulted in the ongoing COVID-19 pandemic which has already caused 4.9 million infections and more than 326,000 fatalities. To initiate infection the SARS-CoV-2 spike (S) glycoprotein promotes attachment to the host cell surface, determining host and tissue tropism, and fusion of the viral and host membranes. Although SARS-CoV-2 S is the main target of neutralizing antibodies and the focus of vaccine design, its stability and conformational dynamics are limiting factors for developing countermeasures against this virus. We report here the design of a prefusion SARS-CoV-2 S ectodomain trimer construct covalently stabilized in the closed conformation. Structural and antigenicity analysis showed we successfully shut S in the closed state without otherwise altering its architecture. Finally, we show that this engineering strategy is applicable to other β-coronavirus S glycoproteins and might become an important tool for vaccine design, structural biology, serology and immunology studies.
ChemInform Abstract: Synthesis and Reactions of Cyanovinyl‐Substituted Benzenediazonium Salts for Nonlinear Optics. (1989)

Abstract Diazotization of the p‐(dicyanovinyl)anilines (I) produces the diazonium salts (III) which are coupled with the anilines (IV) to give the azo dyes (V).
Multi-agent Policy Optimization for Pilot Selection in Delay-constrained Grant-free Multiple Access (2021)

Grant-free multiple access (GFMA) mitigates the uplink handshake overhead to support low-latency communication by transmitting payload data together with the pilot (preamble). However, the channel capacity with random access is limited by the number of available orthogonal pilots and the incoordination among devices. We consider a delay-constrained GFMA system, where each device with randomly generated data traffic needs to deliver its data packets before some pre-determined deadline. The pilot selection problem is formulated to minimize the average packet drop rate of the worst user. A priority-sorting based centralized policy is derived by introducing a fairness promoting function. For decentralization, we propose a multi-agent policy optimization algorithm with improved sample efficiency by exploring the model structure. Simulation results show that our proposed scheme facilitates near-optimal coordination between devices by using only partial state information.
Analysis of Massive MIMO and Base Station Cooperation in an Indoor Scenario (2018)

The performance of centralized and distributed massive MIMO deployments are analyzed for indoor office scenarios. The distributed deployments use one of the following precoding methods: (1) local precoding with local channel state information (CSI) to the user equipments (UEs) that it serves; (2) large-scale MIMO with local CSI to all UEs in the network; (3) network MIMO with global CSI. For the distributed deployments (2) and (3), it is shown that using twice as many base station antennas as data streams provides many of the massive MIMO benefits in terms of spectral efficiency and fairness. This is in contrast to the centralized deployment and the distributed deployment (1) where more antennas are needed. Two of the main conclusions are that distributing base stations helps to overcome wall penetration loss; however, a backhaul is required to mitigate inter-cell interference. The effect of estimation errors on the performance is also quantified.
Hsp27 blockade selectively inhibits growth of tumors with an activated PI3K pathway by regulating Akt and PEA-15 (2008)

3553 Hsp27 is a cytoprotective chaperone that is over-expressed in a wide range of malignancies and is associated with poor prognosis and therapeutic resistance. OGX-427, a selective inhibitor of Hsp27 expression has recently entered Phase I clinical trials for treatment of patients with prostate, breast, ovarian and lung cancers. Here we show that Hsp27 blockade selectively inhibits growth of cancer cells with an activated PI3K pathway and the Hsp27 chaperone is required for Akt stability and activity that, in turn, regulates phosphorylation and function of PEA-15. Hsp27 induces dual coordinated effects resulting in protection from Fas-induced apoptosis and promotion of cell proliferation through regulation of PEA-15 phosphorylation and function in an Akt dependent manner. Hsp27 overexpression induced activation of Akt and increased phosphorylation of its downstream target PEA15 resulting in enhanced ERK translocation to nucleus and increased Elk-1 activity which correlated with increased cyclin D1 and CDK2 expression with a concomitant decrease in p27kip1 expression and increased cell proliferation. Furthermore, Hsp27 overexpression also led to increased association of PEA-15 with FADD and decreased sensitivity of cells to Fas-induced apoptosis . Conversely, Hsp27 knockdown led to reduced Akt activity and decreased phosphorylation of PEA-15 leading to reduced association of PEA-15 with FADD and increased sensitivity of cells to Fas induced apoptosis. Significantly, siRNA mediated Hsp27 knockdown in a panel of cell lines and in PTEN Tet-ON LNCaP cells that express PTEN in a doxycycline inducible manner demonstrated selective inhibition of growth of cancer cells that have an activated PI3K pathway. Collectively, these data identify a dual role of Hsp27 in regulating cell proliferation and Fas-induced apoptosis through regulation of Akt and PEA-15 and suggest that improved clinical responsiveness to Hsp27 targeted therapy may be achieved by stratifying patient populations based on the dependence of cancer cells on the PI3K pathway.
Optimization of Single Voxel MR Spectroscopy Sequence Parameters and Data Analysis Methods for Thermometry in Deep Hyperthermia Treatments (2016)

The Lorentz peak-fitting method in MATLAB was the most reliable peak analyzing method. Measurements in homogeneous and heterogeneous phantoms resulted in optimized parameters for the magnetic resonance spectroscopy sequence for thermometry.