gebhart/patrepeval huggingface dataset:
Combined Approach of NMR and Molecular Dynamics within a biphasic Membrane Mimetic: Conformation and Orientation of the Bradykinin Antagonist Hoe 140 (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCombined Approach of NMR and Molecular Dynamics within a biphasic Membrane Mimetic: Conformation and Orientation of the Bradykinin Antagonist Hoe 140Wolfgang Guba, Rainer Haessner, Gerd Breipohl, Stefan Henke, Jochen Knolle, Vincenzo Santagada, and Horst KesslerCite this: J. Am. Chem. Soc. 1994, 116, 17, 7532–7540Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/ja00096a009https://doi.org/10.1021/ja00096a009research-articleACS PublicationsRequest reuse permissionsArticle Views187Altmetric-Citations78LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis and Properties of Benzene-Fused Diporphyrins with Various Metals (2009)

Various metalloporphyrins bearing a dihydroethanoisoindole unit were prepared by the inverse-type [3+1] porphyrin synthesis of a bicyclo[2.2.2]octadiene[BCOD]-connected dipyrrole with tetrahydrotripyrrindicarbaldehyde followed by metallation. Another [3+1] porphyrin synthesis of the pyrrole-connected porphyrins followed by the second metallation afforded BCOD-connected diporphyrins with different metals. Thermal conversion of the BCOD skeleton into benzene moiety gave π-system-fused diporphyrin with the different metals in a highly pure form.
Supplemenatry Fig. S1 from The Tyrosine Kinase Inhibitor Imatinib Augments Extracellular Fluid Exchange and Reduces Average Collagen Fibril Diameter in Experimental Carcinoma (2023)

&lt;p&gt;Collagen synthesis in STI571-treated KAT-4 carcinoma&lt;/p&gt;
Meniscus Behavior of Metals and Oxides in Molten Carbonate under Oxidant and Reducing Atmospheres: I. Contact Angle and Electrolyte Displacement (1996)

The wetting of metals and oxides by molten carbonate is an important factor affecting the performance of a molten carbonate fuel cell (MCFC). The distribution of the electrolyte among electrodes and matrix in the MCFC is dominated by the pore characteristics and wetting properties of these components. However, data on wetting, especially under load (current passage), are limited. In this study, the behavior of the meniscus at a metal is used to obtain information on wetting and electrochemical reactions. Meniscus height and current were measured under varioius atmopsheres. The contact angle was calculated from the meniscus height. The electrolyte distribution in the MCFC was estimated using contact angles thus obtained in oxidant and reducing atmospheres. The results suggest that upon applicatioin of load the electrolyte moves from the anode to the cathode and that capillary effects can worsen the performance of a cell, especially if it is in an unbalanced state of electrolyte filling.
A putative processing enzyme for proenkephalin in bovine adrenal chromaffin granule membranes (1989)

A putative processing enzyme for proenkephalin, with activity directed toward basic residues, was purified over 2000-fold from washed bovine adrenal medullary chromaffin granule membranes. The molecular mass of this membrane-bound adrenal trypsin-like enzyme (mATLE) is 31 kDa as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and the enzyme is extremely basic, binding to carboxymethyl-Sephadex at pH 8.5. The pH optimum of mATLE using t-butoxycarbonyl-Glu-Lys-Lys-aminomethylcoumarin as a substrate is 8.5-8.7, and its Km value for this substrate is 2.2 mM. mATLE activity was inhibited by soybean trypsin inhibitor, lima bean trypsin inhibitor, and aprotinin but not by metal chelators or thiol-directed reagents. Sequencing of cleavage products released from Peptide B revealed that the enzyme preferentially cleaves between and following the paired basic residues at positions 23 and 24 of Peptide B (thus generating [Met-enkephalin]-Arg-Phe and Arg-[Met-enkephalin]-Arg-Phe). Dynorphin A was cleaved following a single lysine at position 11 but not at the paired arginine site. Our results suggest that mATLE is a trypsin-like serine protease with the specificity appropriate to that of a proenkephalin processing enzyme.
Power smoothing in an offshore wave energy converter array (2010)

This thesis deals with a system for operation of directly driven offshore wave energy converters. The work that has been carried out includes laboratory testing of a permanent magnet linear generator, wave energy converter mechanical design and offshore testing, and finally design, implementation, and offshore testing of an underwater collector substation. Long-term testing of a single point absorber, which was installed in March 2006, has been performed in real ocean waves in linear and in non-linear damping mode. The two different damping modes were realized by, first, a resistive load, and second, a rectifier with voltage smoothing capacitors and a resistive load in the DC-link. The loads are placed on land about 2 km east of the Lysekil wave energy research site, where the offshore experiments have been conducted. In the spring of 2009, another two wave energy converter prototypes were installed. Records of array operation were taken with two and three devices in the array. With two units, non-linear damping was used, and with three units, linear damping was employed. The point absorbers in the array are connected to the underwater substation, which is based on a 3 m3 pressure vessel standing on the seabed. In the substation, rectification of the frequency and amplitude modulated voltages from the linear generators is made. The DC voltage is smoothened by capacitors and inverted to 50 Hz electrical frequency, transformed and finally transmitted to the on-shore measuring station. Results show that the absorption is heavily dependent on the damping. It has also been shown that by increasing the damping, the standard deviation of electrical power can be reduced. The standard deviation of electrical power is reduced by array operation compared to single unit operation. Ongoing and future work include the construction and installation of a second underwater substation, which will connect the first substation and seven new WECs.
Charlatans' Web: Analysis and Application of Global IP-Usage Patterns of Fast-Flux Botnets (2011)

Abstract : Botnet-based hosting or redirection/proxy services provide botmasters with an ideal platform for hosting malicious and illegal content while affording them a high level of misdirection and protection. Because of the unreliable connectivity of the constituent bots (typically compromised home computers), domains built atop botnets require frequent updates to their DNS records, replacing the IPs of offline bots with online ones to prevent a disruption in (malicious) service. Consequently, their DNS records contain a large number of constantly-changing (i.e.. fluxy) IPs. earning them the descriptive moniker of fast-flux domains when both the content and name servers are fluxy, double fast-flux domains. In this paper, we study the global IP-usage patterns exhibited by different types of malicious and benign domains, including single and double fast-flux domains. We have deployed a lightweight DNS-probing engine, called DIGGER, on 240 PlanetLab nodes spanning 4 continents. Collecting DNS data for over 3.5 months on a plethora of domains, our global vantage points enabled us to identify distinguishing behavioral features between them based on their DNS query results.
Synthesis and color tuning of boron diiminate conjugated polymers with aggregation-induced scintillation properties (2015)

We report film-type scintillators based on conjugated polymers with aggregation-induced emission (AIE) properties and the modulation of their scintillation abilities by chemical modification.
Particle-In-Cell (Pic) Simulations of a Magnetically Insulated Coaxial Diode (MICD) Driven by the Sinus-6 Accelerator: Clarification and Explanation of PIC Electron Population Analysis by Analytically Derived “Fedosov” Solution (2022)

The growing use of magnetically insulated coaxial diodes (MICDs) driven by either high-current or high-voltage generators of pulsed power has been inspired by MICD applications in different O-type high-power microwaves and millimeter-wavelength vacuum electron devices (VEDs) built around linear slow-wave structures (SWSs). Previous studies of MICDs with cold explosive electron emission (EEE) cathodes have relied on either analytical calculations [1] or experimental measurements [2] only, and thus, the underlying physics of MICDs is still not comprehensively studied in computer simulations using modern particle-in-cell (PIC) codes. The scope of this study is to compare the results of PIC simulations of an MICD driven by the high-current pulsed-power SINUS-6 accelerator [3] with the analytically derived “Fedosov” solution [1] for the maximum space-charge-limited (SCL) electron-beam current able extracted from an MICD. In addition, the results of experiments performed using the SINUS-6 electron beam accelerator [4] will be compared. Results of PIC simulations and subsequent analyses of PIC simulation-obtained electron population in the MICD of the SINUS-6 accelerator show that the results obtained in PIC simulations for the maximum axial kinetic energy distributions of the beam electrons and total electron-beam current produced by the MICD almost perfectly correlate with, respectively, the analytically calculated “Fedosov” potential and “Fedosov” current [1] .
Dysregulation of different classes of tRNA fragments in chronic lymphocytic leukemia (2019)

Chronic lymphocytic leukemia (CLL) is the most common human leukemia, and dysregulation of tRNA-derived short noncoding RNA (tsRNA) (tRF-1) expression is an accompanying event in the development of this disease. tsRNAs are fragments originating from the 3' end of tRNA precursors and do not contain mature tRNA sequences. In contrast to tsRNAs, mature tRFs (tRF-3s, tRF-5s, and internal tRFs) are produced from mature tRNA sequences and are redundant fragments. We investigated tsRNA expression in CLL and determined tsRNA signatures in indolent CLL and aggressive CLL vs. normal B cells. We noticed that both <i>ts-43</i> and <i>ts-44</i> are derived from distinct genes of pre-tRNA<sup>His</sup>, and are down-regulated in CLL 3- to 5-fold vs. normal B cells. Thus, we investigated expression levels of tRF-5 fragments from tRNA<sup>His</sup> in CLL samples and healthy controls, and determined that such fragments are down-regulated by 5-fold in CLLs vs. normal controls. Given these results, we investigated the expression of all mature tRFs in CLLs vs. normal controls. We found a drastic dysregulation of the expression of mature tRFs in CLL. In aggressive CLL, for the top 15 up-regulated fragments, linear fold change varied from 2,053- to 622-fold. For the top 15 down-regulated fragments in CLL, linear fold change varied from 314- to 52-fold. In addition, 964 mature tRFs were up-regulated at least 2-fold in CLL, while 701 fragments were down-regulated at least 2-fold. Similar results were obtained for indolent CLL. Our results suggest that mature tRFs may have oncogenic and/or tumor suppressor function in CLL.
Lyophobized Ordered Mesoporous Silica Additives for Li-O2Battery Cathode (2014)

The surface of an ordered mesoporous silica (OMS) was functionalized using 1H,1H,2H,2H-perfluorooctyltrimethoxysilane at 20 o C and 60 o C. It was shown that only elevated temperature allows lyophobic properties on the walls of OMS, eventually preventing pore flooding with nonaqueous electrolytes. The functionalized OMSs (OMS-F) were characterized with various techniques: wettability test, N 2 sorption measurement, high-resolution transmission electron microscopy (HR-TEM). Cathodes of 10 mg/cm 2 loading were prepared with a commercial Pt/C catalyst and polyvinylidene fluoride (PVDF, 2.5 wt.%) binder using a typical doctor blade method on a commercial gas diffusion layer (GDL) in the presence or in the absence of OMS-F additives. Subsequent discharge-charge curves were taken in a 1M LiTFSI-TEGDME electrolyte at 60 o C in pure oxygen atmosphere. It was found that the discharge capacity was significantly affected by OMS-F: 5 wt.% of additive extended discharge capacity by a factor 1.5. On the other hand, a similar OMS material but synthesized at 20 o C did not show lyophobic properties and deteriorated cathode capacity.
Laser light scattering (LLS) to observe plasma impact on the adhesion of micrometer-sized particles to a surface (2023)

Laser Light Scattering (LLS) method, combined with a long-distance microscope was utilized to detect micrometer-sized particles on a smooth substrate. LLS was capable to detect individual particle release, shrink, or fragmentation during exposure to a plasma or a gas jet. In-situ monitoring of hundreds of particles was carried out to investigate the effect of hydrogen plasma exposure on particle adhesion, morphology, and composition. LLS was calibrated with monodisperse melamine resin spheres with known sizes of 2.14 um, 2.94 um, and 5.26 um in diameter. The lowest achievable noise level of approximately 3% was demonstrated for counting 5.26 um spherical melamine particles. The accuracy for melamine particle size measurements ranged from 50% for 2.14 um particles to 10% for 5.26 um particles. This scatter was taken as the imprecision of the method. Size distribution for polydisperse particles with known refractive index was obtained by interpolating to an effective scattering cross-section of a sphere using Mie theory. While the Abbe diffraction limit was about 2 um in our system, the detection limit for Si particles in LLS according to Mie approximation was assessed to about 3 um, given the limitations of the laser flux, microscope resolution, camera noise, and particle composition. Additionally, the gradual changes in forward scattering cross-sections for Si particles during the exposure to the hydrogen plasma were consistent with Si etching reported in the literature.
Increased Intra‐ and Extracellular Concentrations of γ‐Glutamylglutamate and Related Dipeptides in the Ischemic Rat Striatum: Involvement of γ‐Glutamyl Transpeptidase (1994)

The present work relates to the possibility that the ATP-independent enzyme gamma-glutamyl transpeptidase (EC 2.3.2.2), which has been postulated to be part of an amino acid uptake system, is active during cerebral ischemia. This was evaluated in the ischemic rat striatum by determination of intra- and extracellular concentrations of gamma-glutamyl dipeptides (the products of the transpeptidation) and glutathione (the physiological gamma-glutamyl donor). An ischemic period (0-30 and 31-60 min) resulted in prominent increases in the respective concentration of extracellular gamma-glutamylglutamate (24- and 67-fold), gamma-glutamyltaurine + gamma-glutamylglycine (5.8- and 19-fold), and gamma-glutamylglutamine (2.6- and 6.8-fold) as revealed using in vivo microdialysis. The changes coincided with increased respective extracellular concentrations of glutamate (83- and 115-fold), taurine (17- and 25-fold), glycine (4.6- and 6.1-fold), and glutamine (1.7- and 2.1-fold). Furthermore, under anoxic conditions in vitro (0-30 and 0-60 min), respective striatal tissue concentrations were increased for gamma-glutamylglutamate (20- and 17-fold), gamma-glutamyltaurine (6.7- and 11-fold), gamma-glutamylglutamine (1.7- and 1.2-fold), and gamma-glutamylglycine (14- and 18-fold), whereas glutathione levels were, on an average, decreased by approximately 350 microM. In summary, gamma-glutamyl transpeptidase is involved in de novo dipeptide synthesis in the mammalian brain during anoxic conditions, indicating transport of amino acids such as glutamate.
Longitudinal assessment of cervical spinal cord compartments in multiple sclerosis (2023)

MS patients with clinical disease progression demonstrate subtle signs of a more pronounced tissue loss at the level of cSC enlargement. Future studies should consider larger sample sizes and more extended observation periods.
Supplementary Figure S6 from Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions (2023)

Supplementary Figure S6 from Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions
Supplementary Figures and Tables from Orally Bioavailable Androgen Receptor Degrader, Potential Next-Generation Therapeutic for Enzalutamide-Resistant Prostate Cancer (2023)

&lt;p&gt;Supplementary Figures and Tables&lt;/p&gt;
Performance of Noncoherent MFSK Channels with Coding (1974)

International Telemetering Conference Proceedings / October 15-17, 1974 / International Hotel, Los Angeles, California
Torn from the Headlines: AstraZeneca Fined For Illegal Marketing of SEROQUEL (2010)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTTorn from the Headlines: AstraZeneca Fined For Illegal Marketing of SEROQUELCraig W. LindsleyCite this: ACS Chem. Neurosci. 2010, 1, 5, 343Publication Date (Web):May 19, 2010Publication History Published online19 May 2010Published inissue 19 May 2010https://pubs.acs.org/doi/10.1021/cn100043nhttps://doi.org/10.1021/cn100043neditorialACS PublicationsCopyright © 2010 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1014Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (626 KB) Get e-AlertscloseSUBJECTS:Amines,Diseases and disorders,Pharmaceuticals,Receptors,Schizophrenia Get e-Alerts
Half-Sandwich Titanium Complexes Stabilized by a Novel Silsesquioxane Ligand:  Soluble Model Systems for Silica-Grafted Olefin Polymerization Catalysts (1998)

The cuboctameric silsesquioxane silanol (c-C5H9)7Si8O12(OH) has been applied as a model support for silica-grafted olefin polymerization catalysts. Complexes of the type Cp‘‘[(c-C5H9)7Si8O13]TiX2 (Cp‘‘ = 1,3-C5H3(SiMe3)2; X = Cl, CH2Ph) form active α-olefin polymerization catalysts.
Evolution of Water Distribution in PEMFC during On/Off Cycling (2011)

Abstract The evolution of membrane water concentration profile has been studied by small angle neutron scattering during on/off cycling PEMFC operation with fully humidified air in co‐flow configuration. The water concentration profiles during on/off cycling evolve in opposite ways close to the gas inlet and outlet. Whereas the global membrane water content increases at the gas inlet as the fuel cell delivers current, the membranes are dried out at the gas outlet. The balance between the diffusion of water from cathode to anode and the electroosmostic drag from anode to cathode gives a net flow which is different close to the gas inlet and gas outlet. The equilibrium is reached in less than 15 min and it is faster when the fuel cell is switched on that is to say when a proton flows is imposed. Moreoever, the time to equilibrium decreases as the membrane content is increased.
Adverse Events Related to Transcranial Electric Stimulation for Motor-evoked Potential Monitoring in High-risk Spinal Surgery (2019)

4.
The Organometallic Chemistry of Zirconium on an Oxo Surface Provided by p‐tert‐Butylcalix[4]arene (1996)

Distorted into an ellipse, the calix[4]arene units in novel complexes of type 1 bind the hexacoordinate Zr center. In complex 1, which is prepared in two steps by reaction of BuLi, calixarene, and ZrCl4, the ZrCl2 unit can be replaced by Zr(alkyl)2, Zr(alkyl), Zr(butadiene), and Zr(ketone) moieties. These reactions provide access to organometallic fragments bonded to a polyoxo matrix.
The Relationship Among Carbon Dioxide Pneumoperitoneum, Vasopressin Release, and Hemodynamic Changes (1999)

We assessed the role of vasopressin (VP) for the hemodynamic response to pneumoperitoneum in pigs. Four groups of anesthetized pigs were investigated. Nine pigs were intraabdominally insufflated with CO2 and eight were intraabdominally insufflated with argon; eight pigs received an i.v. injection of 1 mg/kg SR 49059, a VP antagonist, before CO2 insufflation; and six pigs received SR 49059 alone. Hemodynamics, plasma concentrations of VP and vasoactive hormones, and Paco2 were measured. Data were analyzed by using analysis of variance, Student's t-test, and Mann-Whitney U-test. Five minutes after insufflation, changes in systemic vascular resistance (SVR) were significantly correlated with changes in VP (r = 0.72; P = 0.005) but not with changes in epinephrine, norepinephrine, renin activity, or Paco2. SVR increased during CO2 insufflation but not during argon insufflation or CO2 insufflation with a preceding infusion of SR 49059. The SR 49059 injection itself resulted in increases in heart rate and cardiac output and decreases in blood pressure and SVR. We conclude that, during CO2 pneumoperitoneum in pigs, absorbed CO2 initiates a pathophysiological process that stimulates VP release. Hence, VP most likely plays a key role in the hemodynamic response to a CO2-induced pneumoperitoneum.Intraabdominal insufflation of CO2 is associated with hemodynamic and hormonal changes. Investigating CO2 and argon-insufflated pigs and using a vasopressin antagonist, we found that CO2 insufflation released vasopressin, which, in turn, induced hemodynamic perturbances.
A novel microfluidic cell-chip for single cell analysis and manipulation (2003)

A flow-through microfluidic single cell analysis and manipulation chip is designed, fabricated, and characterized. This paper presents detailed information on the chip's design, fabrication, and characterization. The novel cell-chip is capable of electrically interfacing and interacting with single cells, thus performing precise analysis and manipulation on cell membrane permeability, which is highly important for analyzing and altering biochemical state of cells. Individual cells can either be immobilized in the chip under continuous examination to test cellular responses to specific reagents, or handled in a flow-through fashion for high-throughput cell assays, such as gene transfer and viability determination.