gebhart/patrepeval huggingface dataset:
MmWave channel propagation modeling in 5G high-dense wireless networks (2022)

In a near future perspective, fully connected ubiquitous smart environments will involve numerous wireless communication systems operating simultaneously in heterogeneous networks. This paradigm will require fast, reliable, and secure user services and applications, accessible anytime and anyplace, regardless the devices, networks, or systems they use. For that purpose, adequate, efficient, and effective millimeter wave channel propagation modeling for 5G high-node scenarios is pivotal, in order to prevent communication limitations such as coverage, capacity, or channel interferences due to channel restrictions at these frequency bands. In this work, the densification impact characterization of 5G FR2 communication systems operating in an indoor complex heterogeneous environment is analyzed, by means of deterministic simulation techniques and empirical validation. These results and the proposed simulation methodology can lead in an adequate millimeter wave channel characterization, which provide suitable information for the overall network performance in complex heterogeneous high-node context-aware environments.
Sustainable chemistry: how to produce better and more from less? (2017)

This review describes the rapid evolution of chemistry in the context of a sustainable development of our society. Written in collaboration between scientists from different horizons, either from public organizations or chemical companies, we aim here at providing recommendations to accelerate the emergence of eco-designed products on the market.
Ocean medium and platform effects on synthetic aperture sonar (1990)

Synthetic aperture methods have been extensively used in radar ground mapping and imaging since the 1950s. They have also been discussed and occasionally used in biomedical and nondestructive testing ultrasound, and in hydrographic sonar since the late 1960s. A recent example of a synthetic aperture sonar (SAS) is that of Gough and Hayes [J. Acoust. Soc. Am. 86, 2328-2333 (1989)]. In order for SAS to form sharp images, both the amplitude and phase content of a collection of sequential echo histories of a target, for example a point target on the ocean bottom, must be known. The collection of echo histories represent data taken over the length of a synthesized aperture, usually from a sonar platform moving at a known speed. If the phase is not accurately measured over the synthesized length, the image resulting from the signal processing will be blurred or even absent. Medium instability, multipath effects, and uncorrected platform motion may all contribute to phase errors that lead to blurred images. This paper will discuss SAS and these related ocean medium and platform influences, and show numerical examples of image degradation due to these effects. [Work supported by the Charles Stark Draper Laboratory, Cambridge, MA.]
A micromechanical thermal displacement sensor with nanometre resolution (2005)

A novel micromachined silicon displacement sensor based on the conduction of heat between two surfaces through the ambient air is described. A displacement resolution of less than 1 nm and a dynamic range of more than 100 µm was achieved in a 10 kHz bandwidth. To minimize drift, the sensors are operated in pairs, using a differential measurement configuration. The power consumption of these devices is on the order of 10 mW per sensor, and the measured time response is described by a simple exponential with a time constant of approximately 100 µs.
Hydrogen Gas Sensing using Two Type of Pressure Gauges (2005)

For safety hydrogen sensing, the pressure measurement with a capacitance manometer and a quartz friction pressure gauge (Q-gauge) were investigated. Q-gauge pressure reading decreases when hydrogen gas is introduced into air supplied from atmosphere without any change of pressure measured by a capacitance manometer. This result indicates that the present pressure measurement using two pressure gauges is possible to detect the hydrogen leakage into air. In addition, a decrease of Q-gauge pressure reading correlates with a flow rate of the hydrogen gas, and increases with hydrogen concentration in air. Then it was shown that the low detection limit of hydrogen concentration is below 1%. Response time for hydrogen introduction is faster than 30 seconds, which meets the requirements for the hydrogen gas leak sensor. As above, the present safe pressure measurement using a capacitance manometer and a Q-gauge is satisfactorily useful for the hydrogen gas leak sensing.
Characterizing Effects of Subthalamic Nucleus Deep Brain Stimulation on Methamphetamine-Induced Circling Behavior in Hemi-Parkinsonian Rats (2012)

The unilateral 6-hydroxydopamine (6-OHDA) lesioned rat model is frequently used to study the effects of subthalamic nucleus (STN) deep brain stimulation (DBS) for the treatment of Parkinson's disease. However, systematic knowledge of the effects of DBS parameters on behavior in this animal model is lacking. The goal of this study was to characterize the effects of DBS on methamphetamine-induced circling in the unilateral 6-OHDA lesioned rat. DBS parameters tested include stimulation amplitude, stimulation frequency, methamphetamine dose, stimulation polarity, and anatomical location of the electrode. When an appropriate stimulation amplitude and dose of methamphetamine were applied, high-frequency stimulation (> 130 Hz), but not low frequency stimulation (< 10 Hz), reversed the bias in ipsilateral circling without inhibiting movement. This characteristic frequency tuning profile was only generated when at least one electrode used during bipolar stimulation was located within the STN. No difference was found between bipolar stimulation and monopolar stimulation when the most effective electrode contact was selected, indicating that monopolar stimulation could be used in future experiments. Methamphetamine-induced circling is a simple, reliable, and sensitive behavioral test and holds potential for high-throughput study of the effects of STN DBS in unilaterally lesioned rats.
Fuels and Energy for the Future: The Role of Catalysis (2004)

Abstract There are many reasons to decrease the dependency on oil and to increase the use of other energy sources than fossil fuels. The wish for energy security is balanced by a wish for sustainable growth. Catalysis plays an important role in creating new routes and flexibility in the network of energy sources, energy carriers, and energy conversion. The process technologies resemble those applied in the large scale manufacture of commodities. This is illustrated by examples from refinery fuels, synfuels, and hydrogen and the future role of fossil fuels is discussed. Keywords: CatalysisCO2 Coal conversionDesulphurizationDMEFischer TropschFuel cellsHydrogenMethanolNatural gas conversionSteam reformingSynfuels Acknowledgments Thanks are given to Hakon Mosbech (Elkraft), and to my colleagues, John Bøgild Hansen, Ib Dybkjær, P.E. Højlund Nielsen, Thomas Rostrup‐Nielsen, and Peter Schoubye for useful suggestions.
An Unusual Papain Fragment Containing the VH Region of an IgG3 Myeloma Protein (1972)

Abstract A new enzymatic fragment resulting from papain digestion of an IgG3k myeloma cryoglobulin (protein KUP) is described. This fragment, which can be easily separated from the remainder of the Fab fragment by filtration on Sephadex G-100 in 1 N acetic acid, does not react with a panel of antisera in double diffusion experiments, has a blocked amino-terminal residue and was shown to correspond to most of the heavy chain variable region. It has been tentatively designated Fdv. Fdv is readily soluble in acidic buffers, has a molecular weight of 11,900, a sedimentation coefficient of 1.7S in 1 N acetic acid and contains about 100 residues. Attempts to isolate, under the same conditions, an analogous fragment from two additional IgG3 and one IgG1 myeloma proteins and from pooled human Cohn FII were unsuccessful. Whether production of Fdv is a unique property of protein KUP or is related to an unusual VH subgroup or other factors, remains, so far, undetermined.
Highly Oxidized Ellagitannins of Carpinus japonica and Their Oxidation–Reduction Disproportionation (2020)

In the research on ellagitannin metabolism, two unique dehydroellagitannins, carpinins E (<b>1</b>) and F (<b>2</b>), bearing dehydrohexahydroxydiphenoyl (DHHDP) and hydrated biscyclohexenetrione dicarboxyl ester (HBCHT) groups, were isolated from young leaves of <i>Carpinus japonica</i>. Upon heating in H<sub>2</sub>O or treatment with pH 6 buffer at room temperature, <b>1</b> and <b>2</b> afforded the reduction product <b>3</b>, isocarpinin A, with an (<i>R</i>)-hexahydroxydiphenoyl (HHDP) group, suggesting the occurrence of redox disproportionation of the (<i>S</i>)-DHHDP group. This was supported by the increase in production of <b>3</b> in the pH 6 buffer solution by coexistence of epigallocatechin-3-<i>O</i>-gallate (<b>15</b>), accompanied by oxidation of <b>15</b>. In contrast, treatment of <b>1</b> and <b>2</b> with ascorbic acid yielded <b>4</b>, carpinin A, with an (<i>S</i>)-HHDP group. Upon heating with ascorbic acid, the HBCHT group was also reduced to an (<i>S</i>)-HHDP group, and <b>2</b> was converted to 2,3;4,6-bis(<i>S</i>)-HHDP glucose. In leaves of <i>C. japonica</i>, the tannins <b>1</b> and <b>2</b> are dominant in young spring leaves, but compounds <b>3</b> and <b>4</b> become the major components of tannins in mature leaves. These results suggest that, in ellagitannin biosynthesis, oxidative coupling of the two galloyl groups first generates a DHHDP group, and subsequent reduction of DHHDP esters produces HHDP esters.
Characterization and Electrochemical Properties of Li+ Ion-Exchanged Products of Hollandite-Type Ky(Mn1-xCox)O2 for Lithium Battery Electrodes (2006)

Abstract not Available.
Microbial Community Structure of a Leachfield Soil: Response to Intermittent Aeration and Tetracycline Addition (2013)

Soil-based wastewater treatment systems, or leachfields, rely on microbial processes for improving the quality of wastewater before it reaches the groundwater. These processes are affected by physicochemical system properties, such as O2 availability, and disturbances, such as the presence of antimicrobial compounds in wastewater. We examined the microbial community structure of leachfield mesocosms containing native soil and receiving domestic wastewater under intermittently-aerated (AIR) and unaerated (LEACH) conditions before and after dosing with tetracycline (TET). Community structure was assessed using phospholipid fatty acid analysis (PLFA), analysis of dominant phylotypes using polymerase chain reaction-denaturing gradient gel electrophoresis (PCR–DGGE), and cloning and sequencing of 16S rRNA genes. Prior to dosing, the same PLFA biomarkers were found in soil from AIR and LEACH treatments, although AIR soil had a larger active microbial population and higher concentrations for nine of 32 PLFA markers found. AIR soil also had a larger number of dominant phylotypes, most of them unique to this treatment. Dosing of mesocosms with TET had a more marked effect on AIR than LEACH soil, reducing the size of the microbial population and the number and concentration of PLFA markers. Dominant phylotypes decreased by ~15% in response to TET in both treatments, although the AIR treatment retained a higher number of phylotypes than the LEACH treatment. Fewer than 10% of clones were common to both OPEN ACCESS Water 2013, 5 506 AIR and LEACH soil, and fewer than 25% of the clones from either treatment were homologous with isolates of known genus and species. These included human pathogens, as well as bacteria involved in biogeochemical transformations of C, N, S and metals, and biodegradation of various organic contaminants. Our results show that intermittent aeration has a marked effect on the size and structure of the microbial community that develops in a native leachfield soil. In addition, there is a differential response of the microbial communities of AIR and LEACH soil to tetracycline addition which may be linked to changes in function.
UTILIZANDO ANÁLISES PARA PROPOR MELHORIAS DE USABILIDADE EM CÂMERA FOTOGRÁFICA PROFISSIONAL (2017)

Em tempos em que os produtos da indstria fotogrfica evoluem e se transformam, as cmeras profissionais no mudaram
Effects of NMDA and calcium channel antagonists on regional cerebral blood flow (1991)

N-Methyl-D-aspartate (NMDA) antagonists and voltage-dependent calcium channel antagonists were tested to determine potential effects on regional cerebral blood flow in the normal rabbit brain. Ketamine had no effects on cortical or hippocampal blood flow, but was found to significantly decrease blood flow in the inferior colliculus. MK-801 decreased blood flow in almost all regions of the brain tested. On the other hand, nimodipine significantly increased flow in the cortex, hippocampus, and tegmentum. Dextromethorphan and dextrorphan, which have been shown to act at the NMDA receptor as well as the dihydropyridine calcium channel, decreased blood flow in the inferior colliculus, but showed no effects in the cortex or hippocampus. These results suggest that the neuroprotective NMDA antagonists do not increase blood flow primarily in the normal brain.
Erratum: Evidence for inhomogeneous broadening in vibrational overtone transitions: Formation of 1,3-cyclohexadiene from c i s-1,3,5-hexatriene [J. Chem. Phys. 8 2, 4791 (1985)] (1985)

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170 Novel gene editing approach to enhance CD38-directed antitumor activity of primary human natural killer cells (2021)

<h3>Background</h3> Natural killer (NK) cells play an important role in the antitumor responses of therapeutic monoclonal antibodies (mAbs) by mediating antibody-dependent cellular cytotoxicity (ADCC). ADCC occurs when tumor-ligated mAbs trigger NK cell killing by engaging CD16 on NK cells. Further, infusions of ex vivo expanded NK cells to potentiate the antitumor effects of mAbs is a promising immunotherapeutic approach. Daratumumab (DARA) is an anti-CD38 mAb used in the treatment of multiple myeloma (MM) that efficiently induces NK-mediated ADCC. However, CD38 is also expressed on NK cells, which leads to DARA-mediated NK cell destruction and impaired ADCC against MM. Harnessing NK cells to fully exploit the ADCC mechanism of DARA has the potential to improve DARA’s efficacy. <h3>Methods</h3> We developed a novel approach to maximize DARA-mediated ADCC against MM by protecting NK cells from DARA targeting while simultaneously boosting their ADCC capacity. We designed a CRISPR/Cas9-based gene editing platform to couple the disruption of CD38 expression with site-specific insertion of a gene encoding a high-affinity variant of CD16 at the CD38 locus in ex vivo expanded NK cells. To achieve this, we delivered a ribonucleoprotein composed of a single guide RNA and Cas9 nuclease to induce a double strand break within CD38, followed by infection with engineered AAV particles to deliver a homology directed repair template encoding either a truncated CD34 reporter or a FLAG-tagged high-affinity CD16 to be integrated at the site of CD38 gene disruption. Gene editing and insertion efficiency were assessed by flow cytometry for CD38, CD34, and/or FLAG. Transgene integration was confirmed by junction PCR. <h3>Results</h3> High CD38 knockout efficiency was achieved (90.1 ± 4.1%). Using an EF-1 alpha promoter-containing CD34 donor template, stable CD34 expression was seen in 90.2 ± 5.1% NK cells. Insertion of high-affinity CD16, as assessed by FLAG expression, was observed in 47.7 ± 6.1% of edited NK cells. NK cells modified to express high-affinity CD16 also exhibited a higher number of CD16-positive NK cells compared to unedited control NK cells (10.94 ± 1.8%). Functionally, CD38 knockout NK cells expressing high-affinity CD16 demonstrated augmented degranulation in ADCC assays and killing of daratumumab-treated MM cells compared to unedited control and CD38 knockout NK cells. <h3>Conclusions</h3> Novel gene editing techniques can be successfully applied to generate NK cells with enhanced antitumor capabilities. We established an efficient gene editing platform that can be utilized to produce NK cells optimized for adoptive combination with daratumumab.
P‐156: Microcavity Structures for White RGBW OLED Displays (2009)

Abstract Microcavity OLED structures can increase on‐axis light output and color purity for colored‐light emitters. Such microcavity structures can also be effectively employed with unpatterned white‐light emitters. The relative performance of such a design is compared to a nonmicrocavity structure. Efficiency, color, and angular performance are measured and discussed.
Protein Modification by ADP-ribose via Acid-labile Linkages (1995)

As substrate for protein-mono-ADP-ribosyltransferases, NAD has been shown to be the donor of ADP-ribose to many different nucleophiles found in proteins. This post-translational modification of proteins has been implicated in the regulation of membrane-associated processes including signal transduction, muscle cell differentiation, and protein trafficking and secretion. Described here is the preparation and chemical characterization of low molecular weight conjugates that were used as models for an acetal linkage between ADP-ribose and the hydroxyl group of a protein acceptor such as serine, threonine, tyrosine, hydroxyproline, or hydroxylysine residues. Model conjugates of ADP-ribose containing an acetal linkage were prepared, their structures were established by NMR, and the chemical stability of the linkage to ADP-ribose was studied and compared to the other known ADP-ribosyl-amino acid linkages. The rapid release of intact ADP-ribose from the acetal model conjugates in 44% formic acid distinguished them chemically from all the other known ADP-ribosyl-amino acid modifications. Rat liver proteins were shown to be modified by ADP-ribose in vivo by acid-labile linkages, providing evidence for a new class of endogenous ADP-ribose modification of animal cell proteins. The amount of modification was approximately 16 pmol of ADP-ribose per mg of total protein, and proteins modified by acid-labile linkages were detected in all subcellular fractions examined, suggesting that the scope of this modification in vivo is broad.
Optical 36QAM transmitter based on two tandem IQ modulators with simplified driving electronics (2013)

To scale up the capacity and spectrum efficiency in optical transmission systems, high-order quadrature-amplitude modulation (QAM), has raised a lot of research attention. Recently, optical 32 or 36QAM has been deployed to realize high spectrum-efficient Nyquist wavelength-division multiplexing transmission with spectral efficiency of up to 8.37b/s/Hz. Usually optical 32 or 36QAM is synthesized using a single in-phase/quadrature (IQ) modulator driven by 6-level driving electronics, which is referred to as “electrical” approach here. Although the single IQ modulator solution has a simple optical hardware, it requires sophisticated technique for preparing superior-quality 6-level electronics by either combining three binary electrical signals or deploying high-speed digital-to-analog converters (DACs). The operation symbol-rate is restricted by the DACs resolution, linearity of driver amplifiers or bandwidth of electrical components. On the other hand, the tandem-modulator approach, a serial combination of IQ modulators has been utilized for synthesizing various multilevel optical signals such as 8QAM and 16QAM, where only binary electronics are deployed to drive each modulator. If extending this scheme to generate higher-order QAM, we can also benefit from the reduced complexity in driving electronics. Instead of preparing superior-quality 6-level electronics for generating 36QAM, just binary and 3-level electronics are required. In contrast to the “electrical” approach, the proposed scheme provides an alternative approach to synthesize high-order QAM with simplified driving electronics.
Field of view characterization of Arecibo radio telescope with a phased array feed (2011)

To prepare for a permanent wide-field, L-band phased array feed on the Arecibo radio telescope, a focal plane characterization experiment was conducted from July-August 2010. Experimental and numerical results indicate that a continuous field of view equivalent to 40 beams overlapping at half power is achievable.
Enhancing the Physical Properties and Lifespan of Bacterial Quorum Quenching Media through Combination of Ionic Cross-Linking and Dehydration (2017)

Quorum quenching (QQ) bacteria entrapped in a polymeric composite hydrogel (QQ medium) have been successfully applied in membrane bioreactors (MBRs) for effective biofouling control. However, in order to bring QQ technology closer to practice, the physical strength and lifetime of QQ media should be improved. In this study, enforcement of physical strength, as well as an extension of the lifetime of a previously reported QQ bacteria entrapping hollow cylinder (QQ-HC), was sought by adding a dehydration procedure following the cross-linking of the polymeric hydrogel by inorganic compounds like Ca<sup>2+</sup> and boric acid. Such prepared medium demonstrated enhanced physical strength possibly through an increased degree of physical cross-linking. As a result, a longer lifetime of QQ-HCs was confirmed, which led to improved biofouling mitigation performance of QQ-HC in an MBR. Furthermore, QQ-HCs stored under dehydrated condition showed higher QQ activity when the storage time lasted more than 90 days owing to enhanced cell viability. In addition, the dormant QQ activity after the dehydration step could be easily restored through reactivation with real wastewater, and the reduced weight of the dehydrated media is expected to make handling and transportation of QQ media highly convenient and economical in practice.
Novel syntheses of pyrido[1,2-a]pyrimidin-2-ones, 2H-quinolizin-2-ones, pyrido[1,2-a]quinolin-3-ones, and thiazolo[3,2-a]pyrimidin-7-ones (2004)

As novel 1,3-bis-electrophilic synthons, 1-benzotriazolyl-2-propynones provide access to the fused ring systems of pyrido[1,2-a]pyrimidin-2-ones and 2H-quinolizin-2-ones, known for their diverse biological activities. Reactions of N-(phenylpropioyl)benzotriazole (13a) with substituted 2-aminopyridines 14 afforded pyrido[1,2-a]pyrimidin-2-ones 16a-c in good yields (71-73%). Likewise, 2H-quinolizin-2-ones 18a-f were obtained in moderate to good yields (39-81%) from reactions of benzotriazolyl-2-propynones 13a,b with substituted 2-picolines 14. Extension of this methodology to other fused ring systems has provided 1-alkyl-and 1-arylpyrido[1,2-a]quinolin-3-ones 20a,b (40%) and 5-phenylthiazolo[3,2-a]pyrimidin-7-one (22) (54%) in moderate yields.
Data-based simultaneous design of composite feedback-feedforward controllers: A virtual input direct design approach (1997)

This paper presents a new model reference approach to the design of composite feedback-feedforward controllers using I/O data of the plant. The method is direct, as no plant-identification step is required to design the controller components. The basic idea is that of interpreting the open-loop I/O measurements on the plant as closed-loop data produced by a "virtual" reference signal that can be computed by back-propagating the measured output of the plant through the reference model; thus, the controller design reduces to a standard identification problem, in which the output signal to be matched is the measured input of the plant. Both a deterministic (noise-free) setting and a stochastic setting, for the case of noisy data due to unknown disturbances acting on the plant, are considered. In both cases, the controller designed by the new method is shown to coincide under suitable conditions with the one given by a standard (model-based) indirect method applied to the (unknown) data-generating model.