gebhart/patrepeval huggingface dataset:
Evaluation and Selection of Bacillus Species Based on Enzyme Production, Antimicrobial Activity, and Biofilm Synthesis as Direct-Fed Microbial Candidates for Poultry (2016)

Social concern about misuse of antibiotics as growth promoters (AGP) and generation of multidrug-resistant bacteria have restricted the dietary inclusion of antibiotics in livestock feed in several countries. Direct-fed microbials (DFM) are one of the multiple alternatives commonly evaluated as substitutes of AGP. Sporeformer bacteria from the genus <i>Bacillus</i> have been extensively investigated because of their extraordinary properties to form highly resistant endospores, produce antimicrobial compounds, and synthesize different exogenous enzymes. The purpose of the present study was to evaluate and select <i>Bacillus</i> spp. from environmental and poultry sources as DFM candidates, considering their enzyme production profile, biofilm synthesis capacity, and pathogen-inhibition activity. Thirty-one <i>Bacillus</i> isolates were screened for <i>in vitro</i> relative enzyme activity of amylase, protease, lipase, and phytase using a selective media for each enzyme, with 3/31 strains selected as superior enzyme producers. These three isolates were identified as <i>Bacillus subtilis</i> (1/3), and <i>Bacillus amyloliquefaciens</i> (2/3), based on biochemical tests and 16S rRNA sequence analysis. For evaluation of biofilm synthesis, the generation of an adherent crystal violet-stained ring was determined in polypropylene tubes, resulting in 11/31 strains showing a strong biofilm formation. Moreover, all <i>Bacillus</i> strains were evaluated for growth inhibition activity against <i>Salmonella enterica</i> serovar Enteritidis (26/31), <i>Escherichia coli</i> (28/31), and <i>Clostridioides difficile</i> (29/31). Additionally, in previous <i>in vitro</i> and <i>in vivo</i> studies, these selected <i>Bacillus</i> strains have shown to be resistant to different biochemical conditions of the gastrointestinal tract of poultry. Results of the present study suggest that the selection and consumption of <i>Bacillus</i>-DFM, producing a variable set of enzymes and antimicrobial compounds, may contribute to enhanced performance through improving nutrient digestibility, reducing intestinal viscosity, maintaining a beneficial gut microbiota, and promoting healthy intestinal integrity in poultry.
Divergence-based estimation of Rayleigh wave dispersion curves (2023)

We present a novel seismic acquisition and processing technique to efficiently evaluate the local dispersion curves of Rayleigh waves for subsequent inversion of shear velocities and near-surface characterization.The proposed approach consists of computing the ratio between the&amp;#160;(time derivated)&amp;#160;horizontal spectra H(f)=(&amp;#8706;tVx(f)2+&amp;#8706;tVy(f)2)1/2&amp;#160; and the pseudo-divergence spectra D(f), with D being the sum of the horizontal gradients of the horizontal components (i.e. D=&amp;#8706;xVx+&amp;#8706;yVy).The processing method itself is comparable to the commonly used H/V approach, except that the H/D spectral ratio provides a direct estimate of the frequency-dependent phase velocities cR(f)&amp;#160; instead of the site frequency amplification(s). This is demonstrated using synthetic data.We describe how the D component can be obtained in practice, i.e. by finite-differencing closely spaced horizontal phones or potentially using Distributed-Acoustic-Sensing (DAS) and fibre-optic deployed at the surface. Some limitations about wavelength dependency and impact of Love waves are discussed, as well as potential mitigation measures.A field test on several hours of ambient noise data collected in Germany with multi-component geophones results in realistic values of Rayleigh wave velocities ranging from ~770 m/s at 10 Hz to ~500 m/ at 30 Hz. Thanks to the local and omni-directional nature of the estimation, the minimal number of required channels and the applicability to ambient noise, we believe that the proposed H/D method can be an attractive alternative to expensive array-based techniques.
Katalytische Wasserstofffreisetzung aus Ammoniak in ionischen Flüssigkeiten und Salzschmelzen (2010)

hltnis der Edukte spielt vor allem die Reaktorgeometrie eine
Experimental model of adaptive body biasing for energy efficiency in 28nm UTBB FD-SOI (2014)

In Ultra-Thin Body and BOX Fully Depleted Silicon-On-Insulator (UTBB FD-SOI) technology, body biasing can be used to achieve better energy efficiency. We propose a simple Time, Energy, Power (TEP) model based on Ring Oscillators (RO) measurements to predict optimal (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dd</sub> ;V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">bb</sub> ) point for complex circuits and validate it against direct experimental measurements. The model predicted Adaptive Forward Body Biasing (A-FBB) energy gain is compared to V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dd</sub> only methods: supply scaling, Vdd hopping and power gating.
Objective measures of adenomyosis on MRI and their diagnostic accuracy—a systematic review & meta‐analysis (2021)

A wide range of objective parameters for adenomyosis exist on MRI; however, in many cases their individual diagnostic performance remains uncertain. JZ characteristics remain the most widely used and investigated with acceptable diagnostic accuracy. Specific research is needed into how these objective measures of adenomyosis can be correlated to clinical outcomes.
Resiliency use cases in SPRING networks (2016)

This document identifies and describes the requirements for a set of
use cases related to network resiliency on Segment Routing (SPRING)
networks.
Risk Factors for Recurrence of Shoulder Instability After Arthroscopic Bankart Repair (2006)

In the treatment of traumatic recurrent anterior shoulder instability, patients with bone loss or with shoulder hyperlaxity are at risk for recurrent instability after arthroscopic Bankart repair. At least four anchor points should be used to obtain secure shoulder stabilization.
Security Analysis of Android Automotive (2020)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;In-vehicle infotainment (IVI) platforms are getting increasingly connected. Besides OEM apps and services, the next generation of IVI platforms are expected to offer integration of third-party apps. Under this anticipated business model, vehicular sensor and event data can be collected and shared with selected third-party apps. To accommodate this trend, Google has been pushing towards standardization among proprietary IVI operating systems with their &lt;i&gt;Android Automotive&lt;/i&gt; platform which runs natively on the vehicle’s IVI platform. Unlike &lt;i&gt;Android Auto&lt;/i&gt;’s limited functionality of display-projecting certain smartphone apps to the IVI screen, Android Automotive will have access to the in-vehicle network (IVN), and will be able to read and share various vehicular sensor data with third-party apps. This increased connectivity opens new business opportunities for both the car manufacturer as well as third-party businesses, but also introduces a new attack surface on the vehicle. Therefore, Android Automotive must have a secure system architecture to prevent any potential attacks that might compromise the security and privacy of the vehicle and the driver. In particular, malicious third-party entities could remotely compromise a vehicle’s functionalities and impact the vehicle safety, causing financial and operational damage to the vehicle, as well as compromise the driver’s privacy and safety.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;This paper presents an Android Automotive system architecture and provides guidelines for conducting a high-level security analysis. It also describes what countermeasures have already been taken by Google to prevent potential attacks, and discusses what still needs to be done in order to offer a secure and privacy-preserving Android experience for next-generation IVI platforms.&lt;/div&gt;&lt;/div&gt;
Primary blast lung injury prevalence and fatal injuries from explosions (2013)

Following IED strikes, mounted fatalities are primarily caused by head and chest injuries. Lower extremity trauma is the leading cause of death in dismounted fatalities. Mounted fatalities have a high incidence of PBLI, suggesting significant exposure to primary blast. This has not been reported previously. Further work is required to determine the incidence and clinical significance of this severe lung injury in explosive blast survivors. In addition, specific characteristics of the vehicles should be considered.
The electron detection performance of the “Icarus” hCMOS imaging sensor (2021)

Electron-based diagnostics at the National Ignition Facility use Sandia’s Icarus sensors for ultrafast imaging. However, the electron detection performance of these sensors has remained mostly unknown. Previous work characterized the singulated Common Anode photodiode structure of the ”Furi” and ”Hippogriff” but did not include the Common Cathode photodiode structure of the Icarus. Using a fully fabricated Icarus sensor, we measured the cross-sectional geometries and modeled the expected performance; then, we measured the sensor’s EQE, quantum yield, and charge gain with an electron gun. These measurements were essential to understanding the space-charge limitations of the electron-based diagnostics that use them.
Microinjection of monoclonal antibody to protein p53 inhibits serum-induced DNA synthesis in 3T3 cells. (1982)

Monoclonal antibody directed against the transformation-related protein p53 was microinjected manually into the nuclei of quiescent Swiss 3T3 mouse cells. The cells were subsequently stimulated with 10% fetal calf serum. Microinjection of p53 antibody at or around the time of serum stimulation clearly inhibited the subsequent entry of Swiss 3T3 cells into the S phase of the cell cycle. p53 antibody had no effect on serum-stimulated DNA synthesis when it was microinjected 4 hr or later after serum stimulation. Monoclonal antibody to an unrelated antigen, Lyt-2.2, had no effect on serum-stimulated DNA synthesis regardless of the time it was microinjected. Under similar experimental conditions, p53 antibody had no effect on simian virus 40- or adenovirus 2-induced DNA synthesis. These experiments add strength to the suggestion that p53 is involved in the regulation of cell proliferation.
Electrical properties of InAlAs/InGaAs modulation doped structure after SiN passivated annealing (1997)

The effect of thermal annealing on the InAlAs/InGaAs modulation-doped structure, passivated with a SiN film, was investigated. In contrast to the capless sample, the passivated modulation-doped sample exhibited negligible degradation in the two-dimensional electron gas concentration (NS) after annealing at 280 °C, indicating that SiN is an efficient passivation material to ensure good thermal stability for the InAlAs/InGaAs modulation-doped structure. In addition, partial recovery in NS was found by annealing the SiN-passivated sample that had experienced serious NS degradation. A series of secondary ion mass spectroscopy (SIMS) measurements and Hall effect measurements revealed that the recovery of NS is associated with the discharge of fluorine atoms from the Si-doped n-type InAlAs layer.
The Metabolic Syndrome and Chronic Kidney Disease in U.S. Adults (2004)

These findings suggest that the metabolic syndrome might be an important factor in the cause of chronic kidney disease.
Dispersion and Preparation of Nano-AlN/AA6061 Composites by Pressure Infiltration Method (2022)

Nanomaterials play an important role in metal matrix composites (MMC). In this study, 3.0 wt.%, 6.0 wt.%, and 9.0 wt.% nano-AlN-particles-reinforced AA6061 (nano-AlN/AA6061) composites were successfully prepared by pressure infiltration technique and then hot extruded (HE) at 500 °C. The microstructural characterization of the composites after HE show that the grain structure of the Al matrix is significantly refined, varying from 2 to 20 μm down to 1 to 3 μm. Nano-AlN particles in the composites are agglomerated around the matrix, and the distribution of nano-AlN is improved after HE. The interface between AA6061 and nano-AlN is clean and smooth, without interface reaction products. The 3.0 wt.% nano-AlN/AA6061 composite shows an uppermost yield and supreme tensile strength of 333 MPa and 445 MPa, respectively. The results show that the deformation procedure of the composite is beneficial to the further dispersion of nano-AlN particles and improves the strength of nano-AlN/AA6061 composite. At the same time, the strengthening mechanism active in the composites was discussed.
Search for new phenomena with top quark pairs in final states with one lepton, jets, and missing transverse momentum in pp collisions at $$ \sqrt{s} $$ = 13 TeV with the ATLAS detector (2021)

A bstract A search for new phenomena with top quark pairs in final states with one isolated electron or muon, multiple jets, and large missing transverse momentum is performed. Signal regions are designed to search for two-, three-, and four-body decays of the directly pair-produced supersymmetric partner of the top quark (stop). Additional signal regions are designed specifically to search for spin-0 mediators that are produced in association with a pair of top quarks and decay into a pair of dark-matter particles. The search is performed using the Large Hadron Collider proton-proton collision dataset at a centre-of-mass energy of $$ \sqrt{s} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> </mml:math> = 13 TeV recorded by the ATLAS detector from 2015 to 2018, corresponding to an integrated luminosity of 139 fb − 1 . No significant excess above the Standard Model background is observed, and limits at 95% confidence level are set in the stop-neutralino mass plane and as a function of the mediator mass or the dark-matter particle mass. Stops are excluded up to 1200 GeV (710 GeV) in the two-body (three-body) decay scenario. In the four-body scenario stops up to 640 GeV are excluded for a stop-neutralino mass difference of 60 GeV. Scalar and pseudoscalar dark-matter mediators are excluded up to 200 GeV when the coupling strengths of the mediator to Standard Model and dark-matter particles are both equal to one and when the mass of the dark-matter particle is 1 GeV.
The role of tumor biomarkers as predictors of serum PSA recurrence after radical prostatectomy. (1998)

Tumor biomarkers (p53, bcl-2, Ki-67, and RT-PCR) were reviewed in the literature for their ability to predict prostate-specific antigen (PSA) biological recurrence after radical prostatectomy. All of them are strongly associated with PSA recurrence on univariate analysis. p53 seems to be better than current predictors, such as stage, grade, and positive surgical margins on multivariable analysis; further studies need to confirm bcl-2 and Ki-67 as better predictors of PSA recurrence. However, most of these studies were performed on radical prostatectomy specimens and will need to be confirmed on the preoperative prostate biopsy. The RT-PCR assay was strongly correlated with PSA recurrence and was one of the two best preoperative PSA recurrence predictors with serum PSA.
In Situ Electron Holography of Grain Boundary Schottky Barrier Dynamics in 0.5 Wt% NB Doped SrTiO3 36.8° Symmetric Tilt Bicrystals (1998)

Abstract Electrical phenomena such as positive temperature coefficient of resistance (PTCR), grain boundary layer capacitance, and varistors are controlled by Schottky barriers to current transport formed in grain boundary regions. These grain boundary potential barriers are a result of charged defect accumulation, either through equilibrium segregation or kinetic diffusion processes. Recent work on Nb and Mn doped BaTiO3 highlights the importance of substitutional defects which activate grain boundary trap states and give rise to the PTCR effect. The dynamic interaction of charge carriers with such trap states also produces the rapid electrical breakdown characteristic of varistors. This study explores the issues of defect species, space charge, and electrical transport in donor doped SrTi03 by electron holography and electron energy loss spectroscopy. The specific defect species and mechanisms of current transport through donor doped SrTiO3 remain unresolved because of the difficulty in connecting defect distributions (structural information) and resultant Schottky barrier effects (chemical information).
Different Roles for Caveolin-1 in the Development of Non-Small Cell Lung Cancer versus Small Cell Lung Cancer (2004)

Caveolin-1 (CAV1), an essential structural constituent of caveolae that plays an important role in cellular processes such as transport and signaling, has been implicated in the development of human cancers. However, it is unclear whether CAV1 is acting like an oncogene or tumor suppressor gene. We found that CAV1 expression was reduced or absent in 95% of small cell lung cancers (SCLCs; n = 21 lines), whereas it was retained in 76% of non-small cell lung cancers (NSCLCs; n = 25 lines) compared with normal human lung epithelial cultures, where it was abundantly expressed. CAV1 expression was tightly linked to the ability to grow attached to the plastic cell culture surface, whereas CAV1-nonexpressing lung cancers of both SCLC and NSCLC type grew as suspension cultures. In addition, attached lung cancer cultures expressed phosphorylated focal adhesion kinase, whereas suspension cultures did not. Lack of CAV1 expression was tightly associated with CAV1 promoter methylation (P < 0.0001) such that CAV1 methylation was found in 93% of SCLCs (n = 15) and 9% of NSCLCs (n = 11), whereas 5-aza-2'deoxycytidine treatment restored CAV1 expression in SCLCs. Exogenous CAV1 expression in SCLCs significantly inhibited soft-agar colony formation but did not lead to attachment. By contrast, CAV1 knockdown in NSCLCs mediated by small interfering RNA against CAV1 led to inhibition of cellular proliferation and soft-agar and liquid colony formation. Importantly, CAV1 knockdown led to reduced phospho-focal adhesion kinase and RalA, but not RalB, levels in NSCLC cells. These results suggest different roles for CAV1 in SCLC, where CAV1 acts like a tumor suppressor gene, and NSCLC, where it appears required for survival and growth.
Experimental Demonstrations of Compressive Holography (2009)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text S. Lim, R. Horisaki, K. Choi, D. L. Marks, and D. J. Brady, "Experimental Demonstrations of Compressive Holography," in Frontiers in Optics 2009/Laser Science XXV/Fall 2009 OSA Optics & Photonics Technical Digest, OSA Technical Digest (CD) (Optica Publishing Group, 2009), paper CThA6. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Cellular prion protein localization in rodent and primate brain (1998)

The presence of an abnormal, protease-resistant form of the prion protein (PrP) is the hallmark of various forms of transmissible spongiform encephalopathies (TSE) which can affect a number of mammalian species, including humans. The normal, cellular form of this protein, PrPc, while abundant in brain is also present in many tissues and a number of species. In order to address the unresolved question of the precise localization of normal cerebral PrPc, we used a free-floating immunohistochemistry procedure to localize the protein at both the light and the electron microscopic levels in the brain of three TSE-sensitive species: hamster, macaque and humans. This method shows that PrPc is abundant in synaptic terminal fields in olfactory bulb, limbic-associated structures and in the striato-nigral complex, whereas many other regions of the hamster brain are essentially devoid of immunoreactivity. With the striking exception of the olfactory nerve, in which axons are continually growing throughout life, PrPc is not abundant in fibre pathways. PrPc distribution in the primate hippocampus and cortex is very similar to the distribution observed in hamster. PrPc was present at synaptic profiles as shown by immunoelectron microscopy, but was not detectable in neuronal perikaryon either by light or electron microscopy. Our results show that PrPc is abundant in a number of brain structures known for ongoing plasticity, and are consistent with the hypothesis that the protein also plays a role in synaptic function.
The Complexity of Tumor Vascularity (2003)

Synthetic retinoid-related molecules (RRMs) have been described that show strong antiproliferative activity and induce apoptosis in cancer cells. These RRMs induce caspase activity independently of the retinoid receptors in Jurkat T cells. We observed that the inhibitor of cathepsins B and L Z-FA-fmk blocks the induction of DEVDase activity, DNA fragmentation, and externalization of phosphatidylserine by selective RRMs. Z-FA-fmk can inhibit caspase activity in vitro and selectively inhibits recombinant effector caspases 2, -3, -6, and -7. In contrast, purified initiator caspases 8 and 10 are not affected, whereas the apoptosome-associated caspase 9 is only partially inhibited by Z-FA-fmk in vitro. These data correlate with the covalent binding of biotinylated Z-FA-fmk to the active large subunit of effector caspases. This selective targeting of effector caspases is also observed in Jurkat cells and has been used to demonstrate that RRMs induce apoptosis through the mitochondrial pathway and activate caspase 8 in a Z-FA-fmk-sensitive manner. Thus, Z-FA-fmk fails to inhibit Fas-mediated activation of caspase 8, but completely inhibits RRM-induced processing of caspase 8. Z-FA-fmk does not prevent the autoproteolytic cleavage of caspase 9 in Jurkat cells and partially inhibits the processing and full maturation of effector caspases induced by the RRMs. Moreover, Z-VAD-fmk and Z-FA-fmk have no effect on the release of cytochrome c induced by the RRMs. Other cathepsin inhibitors elicit no effect on RRM-induced apoptosis in Jurkat cells, suggesting that caspases are the major effectors of RRM action.
Elucidating the Rimosamide-Detoxin Natural Product Families and Their Biosynthesis Using Metabolite/Gene Cluster Correlations (2016)

As microbial genome sequencing becomes more widespread, the capacity of microorganisms to produce an immense number of metabolites has come into better view. Utilizing a metabolite/gene cluster correlation platform, the biosynthetic origins of a new family of natural products, the rimosamides, were discovered. The rimosamides were identified in Streptomyces rimosus and associated with their NRPS/PKS-type gene cluster based upon their high frequency of co-occurrence across 179 strains of actinobacteria. This also led to the discovery of the related detoxin gene cluster. The core of each of these families of natural products contains a depsipeptide bond at the point of bifurcation in their unusual branched structures, the origins of which are definitively assigned to nonlinear biosynthetic pathways via heterologous expression in Streptomyces lividans. The rimosamides were found to antagonize the antibiotic activity of blasticidin S against Bacillus cereus.