gebhart/patrepeval huggingface dataset:
Peignes de fréquences femtosecondes pour la mesure des fréquences optiques (2013)

L'avnement des peignes de frquences, au dbut des annes 2000, a rvolutionn la mtrologie des frquences optiques (i.e. quelques centaines de trahertz), et a stimul le dveloppement d'une nouvelle gnration d'horloges atomiques, rfrences sur des transitions optiques. Ces peignes, raliss avec des lasers impulsions femtosecondes, sont aujourd'hui le moyen le plus efficace et fiable pour raliser des comparaisons de frquences entre une horloge du domaine optique et des talons primaires du domaine micro-onde, ainsi qu'entre deux horloges optiques fonctionnant des frquences diffrentes. Nous prsentons dans cet article divers travaux ayant t effectus au LNE-SYRTE pour caractriser ces dispositifs et les amener un niveau de performance tel qu'ils ne limitent pas les mesures effectues partir des horloges du laboratoire.
Flexible Construction of Executable Service Compositions from Reusable Semantic Knowledge (2016)

Most service composition approaches rely on top-down decomposition of a problem and AI-style planning to assemble service components into a meaningful whole, impeding reuse and flexibility. In this article, we propose an approach that starts from declarative knowledge about the semantics of individual service components and algorithmically constructs a full-blown service orchestration process that supports sequence, choice, and parallelism. The output of our algorithm can be mapped directly into a number of service orchestration languages such as OWL-S and BPEL. The approach consists of two steps. First, semantic links specifying data dependencies among the services are derived and organized in a flexible network. Second, based on a user request indicating the desired outcomes from the composition, an executable composition is constructed from the network that satisfies the dependencies. The approach is unique in producing complex compositions out of semantic links between services in a flexible way. It also allows reusing knowledge about semantic dependencies in the network to generate new compositions through new requests and modification of services at runtime. The approach has been implemented in a prototype that outperforms related composition prototypes in experiments.
Intranasal Absorption of the Platelet Glycoprotein IIb/IIIa Receptor Antagonist, DMP 755, and the Effect of Anesthesia on Nasal Bioavailability (1997)

Intranasal absorption and bioavailability of DMP 755, a peptidomimetic, platelet glycoprotein IIb/IIIa receptor antagonist, were examined in anesthetized and lightly sedated dogs. Nasal bioavailability was determined by measuring plasma concentrations relative to those after intravenous dosing. DMP 755 is an ester prodrug, and bioavailability reflects concentrations of the acid hydrolysis product. Nasal bioavailability in dogs anesthetized with pentobarbital was 85 +/- 4%, whereas in dogs anesthetized with the short-acting anesthetic propofol, bioavailability was 32 +/- 7%. Nasal bioavailability was greater than the reported oral bioavailability of DMP 755 in dogs, and was quite consistent. Because anesthesia affects nasal bioavailability, an effect that may depend on the absorption half-life of the test compound, a conscious or lightly sedated animal model is preferred.
Effect of orbiting resonance on the elastic differential cross sections (1975)

Abstract The effects of orbiting resonances on elastic differential cross sections are investigated for the Lennard‐Jones (12, 6) model potential. The elastic differential cross section consists of three terms: a resonance term, a potential scattering term and an interference term. The interference term has a significant effect only at small angles of the differential cross section. The importance of the potential scattering term depends proportionally upon the orbiting resonance energy. For the low‐lying orbiting resonance states, the resonance term is the dominant term, but at higher energy it appears only in the backward differential cross sections. Generally, by fitting the large angle differential cross sections, the resonance orbital angular momentum can be estimated.
Characterization of the Histo-Blood Group O<sup>2</sup> Gene and Its Protein Product (2000)

The O(2) allele has an intact reading frame encoding a protein immunologically related to A/B transferases and enzymatically inactive. Further, our data gave no indication that the O(2) allele is related to the phenomenon of incompatible A antigen expression in gastric cancer.
Non-invasive monitoring of a circadian relevant biomarker from easily accessible body fluids using hybrid aqueous–ionic buffer interfaces on flexible substrates (2019)

In this paper, we demonstrate a hybrid flexible biosensor comprised of an aqueous and ionic interface integrated onto metallic gold microelectrodes for rapid and noninvasive monitoring of cortisol.
Pseudo-rotation in o-isopropylphenylbis(p,p'-bitolyl)phosphorane (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPseudo-rotation in o-isopropylphenylbis(p,p'-bitolyl)phosphoraneGeorge M. Whitesides and William M. BuntingCite this: J. Am. Chem. Soc. 1967, 89, 25, 6801–6802Publication Date (Print):December 1, 1967Publication History Published online1 May 2002Published inissue 1 December 1967https://pubs.acs.org/doi/10.1021/ja01001a095https://doi.org/10.1021/ja01001a095research-articleACS PublicationsRequest reuse permissionsArticle Views57Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On Single-User Interactive Beam Alignment in Millimeter Wave Systems: Impact of Feedback Delay (2021)

Narrow beams are key to wireless communications in millimeter wave frequency bands. Beam alignment (BA) allows the base station (BS) to adjust the direction and width of the beam used for communication. During BA, the BS transmits a number of scanning beams covering different angular regions. The goal is to minimize the expected width of the uncertainty region (UR) that includes the angle of departure of the user. Conventionally, in interactive BA, it is assumed that the feedback corresponding to each scanning packet is received prior to transmission of the next one. However, in practice, the feedback delay could be larger because of propagation or system constraints. This paper investigates BA strategies that operate under arbitrary fixed feedback delays. This problem is analyzed through a source coding perspective where the feedback sequences are viewed as source codewords. It is shown that these codewords form a codebook with a particular characteristic which is used to define a new class of codes called d—unimodal codes. By analyzing the properties of these codes, a lower bound on the minimum achievable expected beamwidth is provided. The results reveal potential performance improvements in terms of the BA duration it takes to achieve a fixed expected width of the UR over the state-of-the-art BA methods which do not consider the effect of delay.
Multivariate analysis (MVA) of progression-free survival (PFS) in two phase IIb, multinational, double-blind, randomized, placebo (PL)-controlled trials evaluating sorafenib (SOR) plus standard chemotherapy in patients (pts) with HER2-negative locally advanced or metastatic breast cancer (BC). (2010)

1073 Background: Two phase IIb trials in pts with advanced BC demonstrated activity for SOR plus standard chemotherapy for the primary endpoint of PFS. In Study A, median PFS for SOR + capecitabine (CAP) versus PL+CAP was 6.4 versus 4.1 mo (hazard ratio [HR] 0.58; 1-sided p=0.0006). In Study B, median PFS for SOR + paclitaxel (PAC) versus PL+PAC was 6.9 versus 5.6 mo (HR 0.79; 1-sided p=0.09). In both studies, randomization was stratified by visceral status with slight imbalances in some covariates. We performed MVA to assess the impact of imbalances and prognostic factors on PFS. Methods: Study A: Pts (N=229) with ≤1 prior chemo regimen for advanced BC were randomized to CAP (1,000 mg/m2 po, twice daily [BID], 14 of 21 days) + SOR (400 mg po, BID) or PL. Study B: Pts (N=237) with no prior chemo for advanced BC were randomized to PAC (90 mg/m2/wk IV, 3 wk on/1 wk off) + SOR (400 mg po, BID) or PL. MVA: Cox proportional hazards models of PFS stratified by visceral status were used for each study. Additional covariates were selected based on degree of imbalance between study arms and prognostic importance and retained if 1-sided p <0.15. Results: After adjusting for covariates, SOR+CAP was associated with a 36% risk reduction vs PL+CAP in Study A, and SOR+PAC with a 27% risk reduction vs PL+PAC in Study B (Table). Conclusions: Primary analysis of PFS favoring chemo with SOR versus PL in two phase IIb advanced BC trials was maintained after adjusting for imbalances. Overall survival data are pending. A large randomized phase III trial of CAP ± SOR is planned. Retained variables HR (95% CI) One-sided p value Study A Hormone status ER—/PR— vs. ER+ or PR+ 2.02 (1.38–2.96) 0.00015 Disease-free interval <2 y vs. 2 y+ 1.31 (0.92–1.87) 0.066 SOR vs. PL 0.64 (0.45–0.91) 0.006 Study B Hormone status ER—/PR— vs. ER+ or PR+ 1.73 (1.16–2.56) 0.003 Unknown vs ER+ or PR+ 1.58 (0.96–2.61) 0.04 Disease-free interval <1 y vs. 1 y+ 1.20 (0.85–1.71) 0.15 Age 50+ vs. <50 y 0.83 (0.58–1.17) 0.14 SOR vs. PL 0.73 (0.52–1.04) 0.04 Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Bayer, Onyx
Precise measurements of the properties of the B1(5721)0,+ and B 2 * (5747)0,+ states and observation of B+,0π−,+ mass structures (2015)

Invariant mass distributions of B + -and B 0 + combinations are investigated in order to study excited B mesons. The analysis is based on a data sample corresponding to 3.0 fb -1 of pp collision data, recorded by the LHCb detector at centre-of-mass energies of 7 and 8 TeV. Precise measurements of the masses and widths of the B 1 (5721) 0,+ and B * 2 (5747) 0,+ states are reported. Clear enhancements, particularly prominent at high pion transverse momentum, are seen over background in the mass range 5850-6000 MeV in both B + -and B 0 + combinations. The structures are consistent with the presence of four excited B mesons, labelled B J (5840) 0,+ and B J (5960) 0,+ , whose masses and widths are obtained under different hypotheses for their quantum numbers.
Design of a prototype system to measure the non-proportional response of scintillators using angular information (2013)

In this paper, a prototype system was designed to efficiently measure the non-proportional electron response of scintillation materials using only angular information. Similar to other measurement systems used in this type of research, our design relies on the fundamental principles of Compton scattering. All current designs measure coincident events that arise when Compton electrons are deposited in a test scintillator while the associated Compton gamma ray is detected by one or more secondary detectors. Nearly all current designs utilize the conservation of energy and a second high-resolution, linear detector in order to determine the energy of the Compton electron. In this work, we use only the angular information and the well known Compton formula which relates scattering angle and energy. By using a position sensitive BGO block detector as the secondary detector, it is possible to simultaneously collect data at multiple scattering angles. The results obtained were found to agree with both literature data and results obtained through a source library measurement. The bias introduced into the results by setup geometry deviations is also discussed.
Targeting mitochondria in cancer therapy could provide a basis for the selective anti-cancer activity (2018)

Abstract To determine the target of the recently identified lead compound NSC130362 that is responsible for its selective anti-cancer efficacy and safety in normal cells, structure-activity relationship (SAR) studies were conducted. First, NSC13062 was validated as a starting compound for the described SAR studies in a variety of cell-based viability assays. Then, a small library of 1,4-naphthoquinines (1,4-NQs) and quinoline-5,8-diones was tested in cell viability assays using pancreatic cancer MIA PaCa-2 cells and normal human hepatocytes. The obtained data allowed us to select a set of both non-toxic compounds that preferentially induced apoptosis in cancer cells and toxic compounds that induced apoptosis in both cancer and normal cells. Anti-cancer activity of the selected non-toxic compounds was confirmed in viability assays using breast cancer HCC1187 cells. Consequently, the two sets of compounds were tested in multiple cell-based and in vitro activity assays to identify key factors responsible for the observed activity. Inhibition of the mitochondrial electron transfer chain (ETC) is a key distinguishing activity between the non-toxic and toxic compounds. Finally, we developed a mathematical model that was able to distinguish these two sets of compounds. The development of this model supports our conclusion that appropriate quantitative SAR (QSAR) models have the potential to be employed to develop anticancer compounds with improved potency while maintaining non-toxicity to normal cells.
Real Time Estimation of Drivers' Behaviour (2015)

The increasing market penetration of in-vehicle sensor technology, e.g., cameras and lidars, is likely to provide more and more insights on drivers' behaviours. Real time knowledge of drivers' behaviour can be useful to a wide range of applications, such as driving assistance in traffic situations identified as critical, detection of tiredness levels or identification of drivers for insurance purposes. In situations where drivers only interact with other vehicles, for instance on highways, the drivers' behaviours can be modelled through microscopic car-following models. Those models are known to be able to capture the physical features of traffic flow, while accurately describing specific drivers' behaviour via behavioural parameters. A lot of research to date has focused on fitting the parameters of these models to real trajectory datasets using off-line techniques, with the objective to reproduce drivers variability in simulation. However very little has been published on online parameter estimation of car-following models. This paper investigates how in-vehicle sensors could help estimate car-following behavioural parameters. The focus is on the Intelligent Driver Model. A discussion of the sensitivity of the estimation is provided in light of previous work, and it is argued that, depending on the traffic state, not all the parameters need to be calibrated. An extended Kalman filter with physical inequality constraints on the behavioural parameters is then formulated for the class of time continuous car-following models. The filter exhibits systematic convergence for real trajectories of leaders and synthetic-simulated-trajectories of followers, for randomly picked parameters within the physical bounds, and for fixed and dynamic observation time steps ranging from 0.1 s up to 1 s. This demonstrates that online parameter estimation of behavioural parameters has great potential.
Naphthalenetetracarboxylic Diimides as Transparent Organic Semiconductors (2010)

This chapter contains sections titled: Introduction Initial Demonstration of NTCDI Semiconductor FETs Further Structural Elaboration of NTCDI Molecular Semiconductors Use of NTCDI Semiconductors in Multifunctional Transistors Conclusion Acknowledgements References
Aβ and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer’s disease (2006)

To date, there is no reasonable explanation as to why plaques and tangles simultaneously accumulate in Alzheimer's disease (AD). We demonstrate here by Western blotting and ELISA that a stable complex can form between tau and amyloid-beta protein (Abeta). This complex enhances tau phosphorylation by GSK3beta, but the phosphorylation then promotes dissociation of the complex. We have localized the sites of this interaction by using peptide membrane arrays. Abeta binds to multiple tau peptides, especially those in exons 7 and 9. This binding is sharply reduced or abolished by phosphorylation of specific serine and threonine residues. Conversely, tau binds to multiple Abeta peptides in the mid to C-terminal regions of Abeta. This binding is also significantly decreased by GSK3beta phosphorylation of tau. We used surface plasmon resonance to determine the binding affinity of Abeta for tau and found it to be in the low nanomolar range and almost 1,000-fold higher than tau for itself. In soluble extracts from AD and control brain tissue, we detected Abeta bound to tau in ELISAs. We also found by double immunostaining of AD brain tissue that phosphorylated tau and Abeta form separate insoluble complexes within the same neurons and their processes. We hypothesize that in AD, an initial step in the pathogenesis may be the intracellular binding of soluble Abeta to soluble nonphosphorylated tau, thus promoting tau phosphorylation and Abeta nucleation. Blocking the sites where Abeta initially binds to tau might arrest the simultaneous formation of plaques and tangles in AD.
High-Speed Silicon-Organic Hybrid (SOH) Modulator with 1.6 fJ/bit and 180 pm/V In-Device Nonlinearity (2013)

We report on a 40 Gbit/s silicon-organic hybrid (SOH) modulator with 11 dB extinction ratio.A novel electro-optic chromophore with record in-device nonlinearity of 180 pm/V leads to V  L = 0.5 Vmm and a low energy consumption of 1.6 fJ/bit at 12.5 Gbit/s.
Snap: Chlorophyll Concentration Calculator Using RAW Images of Leaves (2018)

Determination of nitrogen content, a major component of chlorophyll in plant leaves, is a demand. In this paper we propose Snap, a handheld optical sensor device that uses RAW images of leaves for determining their chlorophyll content. By skipping the pre-processing pipeline at image signal processor, RAW images help to generate a relatively linear relationship between the incident illumination and the calculated pixel value. Pixel values are used to calculate spectral parameters, which are known for their correlation with the chlorophyll concentration. Illumination on the camera lens is controlled by specific geometrical constraints, which are derived using the diffusion properties of the illumination sources. The apparatus banishes influence of external illumination. The approach, by integration with a mobile app, caters to spatial variation of nutrients in soil. A pilot implementation involving 50 cotton plants was conducted for comparing the spectral-parameter value calculated by Snap and SPAD 502 plus Chlorophyll meter. A correlation factor of 0.908 was observed, thereby proving significant similarity but at a tremendously lower cost.
Simultaneous estimation of multi-relay MIMO channels (2013)

This paper addresses training-based channel estimation in distributed amplify-and-forward (AF) multi-input multi-output (MIMO) multi-relay networks. To reduce channel estimation overhead and delay, a training algorithm that allows for simultaneous estimation of the entire MIMO cooperative network's channel parameters at the destination node is proposed. The exact Cram&#x00E9;r-Rao lower bound (CRLB) for the problem is presented in closed-form. Channel estimators that are capable of estimating the overall source-relay-destination channel parameters at the destination are also derived. Numerical results show that while reducing delay, the proposed channel estimators are close to the derived CRLB over a wide range of signal-to-noise ratio values and outperform existing channel estimation methods. Finally, extensive simulations demonstrate that the proposed training method and channel estimators can be effectively deployed in combination with cooperative optimization algorithms to significantly enhance the performance of AF relaying MIMO systems in terms of average-bit-error-rate.
ChemInform Abstract: Rapid Screening for Asymmetric Catalysts: The Efficient Connection of Two Different Catalytic Asymmetric Reactions. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Manipulating Adenovirus Hexon Hypervariable Loops Dictates Immune Neutralisation and Coagulation Factor X-dependent Cell Interaction In Vitro and In Vivo (2015)

Adenoviruses are common pathogens, mostly targeting ocular, gastrointestinal and respiratory cells, but in some cases infection disseminates, presenting in severe clinical outcomes. Upon dissemination and contact with blood, coagulation factor X (FX) interacts directly with the adenovirus type 5 (Ad5) hexon. FX can act as a bridge to bind heparan sulphate proteoglycans, leading to substantial Ad5 hepatocyte uptake. FX "coating" also protects the virus from host IgM and complement-mediated neutralisation. However, the contribution of FX in determining Ad liver transduction whilst simultaneously shielding the virus from immune attack remains unclear. In this study, we demonstrate that the FX protection mechanism is not conserved amongst Ad types, and identify the hexon hypervariable regions (HVR) of Ad5 as the capsid proteins targeted by this host defense pathway. Using genetic and pharmacological approaches, we manipulate Ad5 HVR interactions to interrogate the interplay between viral cell transduction and immune neutralisation. We show that FX and inhibitory serum components can co-compete and virus neutralisation is influenced by both the location and extent of modifications to the Ad5 HVRs. We engineered Ad5-derived HVRs into the rare, native non FX-binding Ad26 to create Ad26.HVR5C. This enabled the virus to interact with FX at high affinity, as quantified by surface plasmon resonance, FX-mediated cell binding and transduction assays. Concomitantly, Ad26.HVR5C was also sensitised to immune attack in the absence of FX, a direct consequence of the engineered HVRs from Ad5. In both immune competent and deficient animals, Ad26.HVR5C hepatic gene transfer was mediated by FX following intravenous delivery. This study gives mechanistic insight into the pivotal role of the Ad5 HVRs in conferring sensitivity to virus neutralisation by IgM and classical complement-mediated attack. Furthermore, through this gain-of-function approach we demonstrate the dual functionality of FX in protecting Ad26.HVR5C against innate immune factors whilst determining liver targeting.
Fluorogel Elastomers with Tunable Transparency, Elasticity, Shape‐Memory, and Antifouling Properties (2014)

Omniphobic fluorogel elastomers were prepared by photocuring perfluorinated acrylates and a perfluoropolyether crosslinker. By tuning either the chemical composition or the temperature that control the crystallinity of the resulting polymer chains, a broad range of optical and mechanical properties of the fluorogel can be achieved. After infusing with fluorinated lubricants, the fluorogels showed excellent resistance to wetting by various liquids and anti-biofouling behavior, while maintaining cytocompatiblity.