gebhart/patrepeval huggingface dataset:
Supplementary Data from A Five-Gene and Corresponding Protein Signature for Stage-I Lung Adenocarcinoma Prognosis (2023)

&lt;p&gt;Supplementary Figures S1-S4; Supplementary Tables S1-S2.&lt;/p&gt;
Intelligent virtual agents for contact center automation (2005)

The explosion of multimedia data, the continuous growth in computing power, and advances in machine learning and speech and natural language processing are making it possible to create a new breed of virtual intelligent agents capable of performing sophisticated and complex tasks that are radically transforming contact centers. These virtual agents are enabling ubiquitous and personalized access to communication services from anywhere. They ultimately provide a vehicle to fully automate eContact services without agent personnel. They are not limited to multimodal, multimedia, and multilingual capabilities, but also possess learning and data-mining capabilities to enable them to scale and self-maintain as well as extract and report on business intelligence. AT&T VoiceTone is a subset of this eContact revolution focused on creating this new wave of intelligent communication services.
Substrate Modulation of the Activity of an Artificial Nanoesterase Made of Peptide‐Functionalized Gold Nanoparticles (2006)

Nanozymes with a heart of gold: A functional artificial protein has been prepared by grafting a dodecapeptide onto the surface of gold nanoparticles (see picture). The system catalyzes the hydrolysis of carboxylate esters and features enzyme-like properties. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z602581_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Relationship between the Electron Affinities and Half-Wave Reduction Potentials of Fullerenes, Aromatic Hydrocarbons, and Metal Complexes (1995)

Differences in energy for neutral molecule and negative ions upon going from the gas phase to solution, -Delta Delta G(sol), have been calculated from gas phase electron affinities and half-wave reduction potentials for a series of fullerenes, aromatic hydrocarbons, metalloporphyrins, and metal complexes in dimethylformamide (DMF). For those compounds with similar charge delocalization, the value of -Delta Delta G(sol) is constant and equal to 1.76 +/- 0.06 eV for the fullerenes, 1.99 +/- 0.05 eV for the aromatic hydrocarbons and the metalloporphyrins, and 2.19 +/- 0.14 eV for the metal acetylacetonates. The fullerenes form a new class of molecules in which the charge is highly delocalized, and this is demonstrated by the relatively low value of -Delta Delta G(sol). A procedure for determining adiabatic electron affinities from reduction potentials, and vice versa, is established. This procedure is applied to benzene to give an electron affinity of -0.7 +/- 0.14 eV, to La@C-82 to give an electron affinity of 3.21 +/- 0.06 eV, and to Y@C-82 to give an electron affinity of 3.32 +/- 0.06 eV. On the other hand, a value of E(1/2) = 0.09 +/- 0.14 V vs SCE is predicted for the reduction of Ca@C-60 in DMF based upon a reported electron affinity of 3.0 +/- 0.1 eV.
Adaptive technique for three-dimensional MR imaging of moving structures. (1990)

The authors describe an adaptive motion correction method for three-dimensional magnetic resonance (MR) imaging. Three-dimensional imaging offers many advantages over two-dimensional multisection imaging but is susceptible to image corruption due to motion. Thus, it has been of limited use in the imaging of mobile structures, and the relatively long imaging times required have hindered its use in patients who tend to move during imaging. The authors' technique uses interleaved "navigator" echoes to provide a measure of displacement for each image echo in the acquisition and then uses this information to allow correction of the image data. The theory for signal corruption due to motion and the correction scheme that follows from it are presented. This method can produce excellent results when the motion is correctly modeled.
ChemInform Abstract: Synthesis of 3‐Arylmuconolactones Using Biphenyl Metabolism in Aspergillus. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Heat-shock-protein-27(HSP27) expression in ovarian carcinoma: Relation in response to chemotherapy and prognosis (1999)

Heat-shock protein 27 (hsp27) is one of the small heat-shock proteins. Its expression in ovarian- and breast-cancer cell lines has been associated with resistance to cisplatin and doxorubicin. In addition, hsp27 expression appears to facilitate cellular growth, differentiation and motility. In several human carcinomas, hsp27 expression might also be related to worse prognosis. The aim of this study was to evaluate the prognostic value of hsp27 expression in patients with ovarian carcinoma in relation to their response to chemotherapy and overall survival. Hsp27 expression was assessed by immunohistochemistry in 77 patients with ovarian carcinoma stage IC-IV. All patients received cisplatin- and doxorubicin-based chemotherapy and had long-term follow-up. In 30 patients, paired tumour samples were available, obtained before and after chemotherapy. Hsp27 immunostaining was positive in 86% of patients before and in 72% of patients after chemotherapy. Hsp27 expression was not related to any clinicopathologic factor, including previously determined p53 expression. Univariate analysis showed that, in stage-III and -IV patients, younger age, no residual tumour after first laparotomy, < or = 1 litre ascites, response to first-line chemotherapy and absence of hsp27 expression were associated with longer median progression-free survival. However, in multivariate analysis, only age, ascites and response to chemotherapy retained independent prognostic value.
Effects of Prior Intensive Insulin Therapy and Risk Factors on Patient-Reported Visual Function Outcomes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Cohort (2015)

clinicaltrials.gov Identifiers: NCT00360815 and NCT00360893.
Sensitivity booster for DOI-PET by utilizing Compton scattering events between detector blocks (2013)

In a conventional PET scanner, coincidence events are measured with the limited energy window for detection of photoelectric events in order to reject Compton scatter events that occur in a patient, but Compton scatter events caused in detector crystals are also rejected. Scatter events within the patient cause scatter coincidences, but inter crystal scattering (ICS) events have useful information for determining an activity distribution. Some researchers have reported the feasibility of PET scanners based on a Compton camera for tracing ICS into the detector. However, these detectors require expensive semiconductor detectors for high-energy resolution. In the Anger-type block detector, single photons interacting with multiple detectors can be obtained for each interacting position and complete information can be gotten just as for photoelectric events in the single detector. ICS events in the single detector have been used to get coincidence, but single photons interacting with multiple detectors have not been used to get coincidence actively. In this work, we developed a new method to improve sensitivity using Compton kinetics in a DOI-PET scanner. The proposed method promises to improve the sensitivity using coincidence events of single photons interacting with multiple detectors, which are identified as the first interaction (FI). FI estimation accuracy can be improved to determine FI validity from the correlation between Compton scattering angles calculated on energy and coincidence LOR. We simulated animal PET scanner consisting of 42 detectors. Each detector block consisted of three types of scintillator crystals (LSO, GSO, GAGG). After the simulation, coincidence events are added as information for several DOI resolutions. From the simulation results, we concluded the proposed method promises to improve the sensitivity considerably as effective Z of the scintillator is low. Also, we showed that FI estimate accuracy is improved, as DOI resolution is high.
Experimental Automatic Lateral Control System For An Automobile - eScholarship (1992)

This report summarizes an experimental effort in integrating and testing an automated vehicle lateral control system. The project, a cooperative effort between the California Partners for Advanced Transit and Highway ( PATH) Program and IMRA America, Inc., included a discrete roadway reference system, on-vehicle magnetic sensing system, a computer control system and a hydraulic actuator.
Side Channels in Multi-Tenant Environments (2015)

Due to the massive adoption of computing platforms that consolidate potentially distrustful tenants' applications on common hardware---both large (public clouds) and small (smartphones)---the security provided by these platforms to their tenants is increasingly being scrutinized. In this talk we review highlights from the last several years of research on a long-suspected but, until recently, largely hypothetical attack vector on such platforms, namely side-channel attacks. In these attacks, one tenant learns sensitive information about another tenant simply by running on the same hardware with it, but without violating the logical access control enforced by the platform's isolation software (virtual machine monitor or operating system). We will then summarize various strategies we have explored to defend against side-channel attacks in their various forms, both inexpensive defenses against specific attacks and more holistic but expensive protections.
Serial exome analysis of disease progression in premalignant gammopathies (2014)

pressure. Accordingly, JMML clones with
Nanocomposites: general discussion (2016)

Yogesh M. Joshi opened a discussion of the paper by Marc Couty: It is indeed a very novel way of manufacturing the composite: first dissolving and swelling Styrene butadiene copolymer in styrene and subsequently crosslinking the latter. Does such assembly have any special benefits in terms of m
Structure of Amyloid A4‐(1–40)‐Peptide of Alzheimer's Disease (1995)

One of the principle peptide components of the amyloid plaque deposits of Alzheimer's disease in humans is the 40-amino-acid peptide beta-amyloid A4-(1-40)-peptide. The full-length A4-(1-40)-peptide was chemically synthesized and the solution structure determined by two-dimensional nuclear magnetic resonance spectroscopy and restrained molecular-dynamics calculations. Synthetic human A4-(1-40)-peptide was soluble and non-aggregating for several days in 40% (by vol.) trifluoroethanol/water. All spin systems could be unambiguously assigned, and a total of 203 sequential and medium-range cross-peaks were found in the NOESY (nuclear Overhauser enhancement spectroscopy) spectrum. Long-range NOE cross-peaks that would indicate tertiary structure of the peptide were absent. The main secondary-structure elements found by chemical-shift analysis, sequential and medium-range NOESY data, and NOE-based restrained molecular-dynamics calculations were two helices, Gln15-Asp23 and Ile31-Met35, whereas the rest of the peptide was in random-coil conformation. A similar secondary structure is suggested for the aggregation part of prions, the postulated causative agents of the transmissible spongiform encephalopathy. The sequence of the helical part of prion proteins was observed to be remarkably similar to the sequence of the helical part of human A4-(1-40)-peptide.
Ultrasonic Intensification Of The Chemical Degradation Of Methyl Violet: An Experimental Study (2011)

The sonochemical decolorization and degradation of azo dye Methyl violet using Fenton-s reagent in the presence of a high-frequency acoustic field has been investigated. Dyeing and textile effluents are the major sources of azo dyes, and are most troublesome among industrial wastewaters, causing imbalance in the eco-system. The effect of various operating conditions (initial concentration of dye, liquid-phase temperature, ultrasonic power and frequency and process time) on sonochemical degradation was investigated. Conversion was found to increase with increase in initial concentration, temperature, power level and frequency. Both horntype and tank-type sonicators were used, at various power levels (250W, 400W and 500W) for frequencies ranging from 20 kHz - 1000 kHz. A 'Process Intensification' parameter PI, was defined to quantify the enhancement of the degradation reaction by ultrasound when compared to control (i.e., without ultrasound). The present work clearly demonstrates that a high-frequency ultrasonic bath can be used to achieve higher process throughput and energy efficiency at a larger scale of operation.
Discovery of the HCV NS3/4A Protease Inhibitor (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key Steps in Structure-Based Optimization (2007)

The structures of both the native holo-HCV NS3/4A protease domain and the protease domain with a serine 139 to alanine (S139A) mutation were solved to high resolution. Subsequently, structures were determined for a series of ketoamide inhibitors in complex with the protease. The changes in the inhibitor potency were correlated with changes in the buried surface area upon binding the inhibitor to the active site. The largest contribution to the binding energy arises from the hydrophobic interactions of the P1 and P2 groups as they bind to the S1 and S2 pockets [the numbering of the subsites is as defined in Berger, A.; Schechter, I. Philos. Trans. R. Soc. London, Ser. B 1970, 257, 249-264]. This correlation of the changes in potency with increased buried surface area contributed directly to the design of a potent tripeptide inhibitor of the HCV NS3/4A protease that is currently in clinical trials.
3rd international workshop on collaborative information retrieval (CIR2011) (2011)

Synchronous, explicit search has some interesting characteristics that distinguish it from other types of interaction: there is much more emphasis on interaction, as the system has to not only communicate search results to the user, but also mediate some forms of communication and data sharing among its users. There are new algorithms that need to be invented that use inputs from multiple people to produce search results, and new evaluation metrics need to be invented that reflect the collaborative and interactive nature of the task. Finally, we need to integrate the expertise of library and information science researchers and practitioners by revisiting real-world information seeking situations with an eye for explicit, synchronous collaborative search.
Log-normal shadowing meets SINR: A numerical study of Capacity in Wireless Networks (2007)

The capacity of wireless multi-hop networks has been studied extensively in recent years. Most existing work tackles the problem from an asymptotic perspective and assumes a simplified physical layer model, as e.g., the protocol interference model or the path loss radio propagation. Real life network planning, provisioning and deployment can only be done with more precise statements about capacity in finite networks. With this in mind, we adopt a numerical approach based on Monte-Carlo methods to study capacity under various interference and radio propagation models, including the physical interference model and log-normal shadowing radio propagation. Our results indicate that, depending on the interference model, capacity may experience a three phase transition related to the connectivity of the network. We further show that throughput capacity increases in the presence of randomized radio propagation, even above the critical node density. Our analysis of the numerical data illustrates that log-normal shadowing creates more interference, but decreases the total amount of transmissions to be scheduled.
On-chip Timing Uncertainty Measurements on IBM Microprocessors (2008)

Timing uncertainty in microprocessors is comprised of several sources including PLL jitter, clock distribution skew and jitter, across chip device variations, and power supply noise. The on-chip measurement macro called SKITTER (SKew+jITTER) was designed to measure timing uncertainty from all combined sources by measuring the number of logic stages that complete in a cycle. This measure of completed delay stages has proven to be a very sensitive monitor of power supply noise, which has emerged as a dominant component of timing uncertainty. This paper describes the Skitter measurement experiences of several IBM microprocessors including PPC970MP, XBOX360 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TM</sup> , CELL Broadband Engine <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TM</sup> , and POWER6 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TM</sup> microprocessors running different workloads.
Partial Interferometric Processing of Reflected GNSS Signals for Ocean Altimetry (2014)

The bistatically reflected global navigation satellite systems (GNSS) signals have become an attractive tool for spaceborne ocean altimetry. The interferometric processing that can exploit the full bandwidth of the available GNSS signals without the knowledge of the actual ranging codes was proposed for the PARIS IoD mission to improve the ranging precision. This letter presents a novel on-board processing method which utilizes the interferometry of partial GNSS signal components to explore a further improvement of the altimetry precision. The scheme of extracting partial signal components and interferometry procedure, for GPS L1 band as an example, are illustrated. The assessment and comparison of achievable altimetric performance of the proposed method including the altimetric sensitivity, the resolution per pulse, the signal-to-noise ratio, and the overall altimetric precision are also introduced. The extension of the proposed method to other existing and planned GNSS systems and signals would guarantee an improvement in the overall performance of the PARIS concept.
Photoelasticity Based Dynamic Tactile Sensor (2005)

The paper presents design, construction and testing of a photoelasticity based dynamic sensor which is capable of detecting slip as well as providing normal force information. Starting with investigations into mechanism of slip, an approximate model of the sensor has been developed. This model explains the design improvements necessary to provide continuous signal during slip. The theoretical model also helps identify various sensor parameters to characterize the sensor. The developed sensor has been compared with other existing sensors and the experimental results from the sensor have been discussed for the type of signal the sensor provides. The sensor is also calibrated for normal force. The sensor is novel in the sense that it offers dynamic slip signal as well as the normal force information from a single contact location, it provides continuous signal during slip, and it has small size which can be easily incorporated into robotic fingers. The sensor has an edge over other existing sensors that its design is simple yet it provides strong signals which are largely unaffected by external disturbances.
Hyperactive Striatal Dopamine Signaling Observed in Huntington’s Disease Mouse Models Prior to Motor Symptom Onset Can be Attenuated via Activation of M 4 Receptors (2022)

Almost all Huntington’s Disease (HD) patients die within 10‐30 years after symptom onset and currently there are no available treatments to slow, stop, or reverse its progression. HD is a neurodegenerative disease that causes a biphasic signaling pattern in the striatum in which there is hyperactive signaling during the early stages, followed by hypoactive signaling later on. Among the many neurotransmitters shown to follow the biphasic signaling pattern found in HD, dopamine (DA) and its inputs from the mid‐brain to the striatum are thought to be critical for motor and action planning. However, there is currently a lack of studies that directly examine DA signaling in animal models before symptom onset, leaving room for investigation in a critical area of the disease. Here we use a combination of techniques to assess dopamine signaling and its regulation during pre‐symptomatic disease stages. We hypothesized that we would observe increased dopamine transients in YAC128 positive mice when compared to littermate controls at this time point, and that activation of the M4 receptor with the M4 selective positive allosteric modulator (PAM) VU’154 would normalize transient amplitude in YAC128 mice. Using fast scanning cyclic voltammetry (FSCV), we recorded dopamine signaling in pre‐symptomatic YAC128 mice via ex vivo preparations. We also used, fiber photometry to record dopamine signaling in vivo, in the same mouse strain. We found that indeed, DA transient amplitudes are increased in pre‐symptomatic YAC128 mice when compared to littermate controls in both ex vivo and in vivo settings. Additionally, we report that activation of the M4 receptor is able to normalize the enhanced DA signaling in HD mice. These findings are some of the first to directly show increased DA signaling in the basal ganglia in early stage HD rodent models and support previous evidence that M4 ­­­­­­­is potentially an exciting target for normalizing aberrant neurotransmission in HD.
c-Myc Antagonises the Transcriptional Activity of the Androgen Receptor in Prostate Cancer Affecting Key Gene Networks (2017)

Prostate cancer (PCa) is the most common non-cutaneous cancer in men. The androgen receptor (AR), a ligand-activated transcription factor, constitutes the main drug target for advanced cases of the disease. However, a variety of other transcription factors and signaling networks have been shown to be altered in patients and to influence AR activity. Amongst these, the oncogenic transcription factor c-Myc has been studied extensively in multiple malignancies and elevated protein levels of c-Myc are commonly observed in PCa. Its impact on AR activity, however, remains elusive. In this study, we assessed the impact of c-Myc overexpression on AR activity and transcriptional output in a PCa cell line model and validated the antagonistic effect of c-MYC on AR-targets in patient samples. We found that c-Myc overexpression partially reprogrammed AR chromatin occupancy and was associated with altered histone marks distribution, most notably H3K4me1 and H3K27me3. We found c-Myc and the AR co-occupy a substantial number of binding sites and these exhibited enhancer-like characteristics. Interestingly, c-Myc overexpression antagonised clinically relevant AR target genes. Therefore, as an example, we validated the antagonistic relationship between c-Myc and two AR target genes, KLK3 (alias PSA, prostate specific antigen), and Glycine N-Methyltransferase (GNMT), in patient samples. Our findings provide unbiased evidence that MYC overexpression deregulates the AR transcriptional program, which is thought to be a driving force in PCa.