gebhart/patrepeval huggingface dataset:
Effect of Magnetic Nanoparticles, Their Size and Functionalization on Liquid Crystal Order (2005)

We have observed the effects of adding magnetic nanoparticles with a different surface termination to smectic A 8CB liquid crystals by examining the liquid crystals both with polarized optical microscopy and by x‐ray scattering. The smectic A liquid crystal is the phase we find in cell walls and other biological components. Adding the magnetic nanoparticles improves the liquid crystals’ response to a magnetic field by at least one to two orders of magnitude. We have performed the experiments with four types of organic compounds covering the nanoparticles, using 11 nm and 2 nm FeCo nanoparticles, and have varied the applied magnetic field from 225 mT to 362 mT. There is a variation on the effect due to the size of the nanoparticles and to the concentration of the particles in the mixture. There is also a variation due to the surface functionalization covering the nanoparticles, which can affect the predicted behavior as a function of particle size. This result is important not only for liquid crystals but for biological applications, because it is the functionalization compound that identifies and targets the molecules.
New fluorescence methodology for detecting DNA adducts. Progress report, May 1, 1991--May 21, 1993 (1993)

A new reagent, BO-IMI, has been developed that achieves, single step, phosphate specific fluorescence labeling under aqueous conditions. Both 3 in. and 5 in. mononucleotides, including representative DNA adducts can be labeled. Included in this technique is a convenient procedure for postlabeling sample cleanup, leading to a practical detection of the products by capillary electrophoresis with laser fluorescencedetection. We consider that this new method will have a significant impact on the measurement of DNA adducts in human samples. This work was largely accomplished in the second half of our project. In the first half, we set up a new way to isolate DNA nucleotides from blood, worked with an initial, less specific technique for labeling DNA adducts, compared ionizing radiation vs oxidative damage to fluorescein labeled deoxyadenylic acid, and set up a capillary electrophoresis laser fluorescence detection system.
Efficient phase conjugation using Raman dark resonances in an optically dense crystal (2003)

Summary form only given. In a three-level system, optical refractive indices can be changed due to the atom-field interactions. Especially in a short time scale (t/spl Lt/ /spl gamma/), a resonant strong electromagnetic field can change the absorption coefficient strongly so that another resonant electromagnetic field which has a different frequency can pass through without experiencing any absorption in an optically dense medium. This phenomenon is called electromagnetically induced transparency (EIT). There have been many studies of EIT in atomic vapors and solids for potential applications to nonlinear optical processes such as enhanced four-wave mixing, lasers without inversion, frequency up-conversion lasers, and optical memory. We report efficient phase conjugation based on EIT in an in homogeneously broadened solid system of Pr/sup 3+/ doped yttrium silicate.
Federation in Dynamic Environments: Can Blockchain Be the Solution? (2022)

Deploying multi-domain network services is becoming a need for operators. However, achieving that in a real operational environment is not easy and requires the use of federation. Federation is a multi-domain concept that enables the use and orchestration of network services/resources to/from external administrative domains. In this article, we first characterize the federation concept and involved procedures, and then dive into the challenges that emerge when federation is performed in dynamic environments. To tackle these challenges, we propose the application of blockchain technology, identifying some associated high-level benefits. Last, we validate our proposed approach by conducting a small experimental scenario using Tendermint, an application-based blockchain.
A pilot study of immune checkpoint inhibition (tremelimumab and/or MEDI4736) in combination with radiation therapy in patients with unresectable pancreatic cancer. (2016)

TPS470 Background: Tremelimumab is a fully human monoclonal antibody that binds to CTLA-4 expressed on the surface of activated T lymphocytes and causes inhibition of B7-CTLA-4-mediated downregulation of T-cell activation. MEDI4736 is a human monoclonal antibody directed against PD-L1. Blockage of ligation between PD-L1 and PD1 induces local immune activation and prevents anergy and exhaustion of effector T-cells. Several studies have documented an increase in peripheral antitumor immunity following radiation. This effect is evidently too weak to be clinically relevant, but has the potential to be boosted by immune modulation. The underlying hypothesis of this study is that the effect of immune checkpoint inhibition (accomplished via tremelimumab and/or MEDI4736) treatment can be enhanced by radiation in patients with advanced pancreatic carcinoma. Whilst radiation treatment in pancreas cancer is commonly employed in limited or early stage disease, if radiation can enhance the effect of immune checkpoint inhibition to produce systemic anti-tumor effects the combination could become an effective treatment modality for patients with advanced disease. Methods: Patients with histologically confirmed metastatic pancreatic cancer with primary in-situ (or locally-recurrent) disease are being enrolled to this pilot study. The primary objectives are to determine the safety, tolerability and feasibility of immune checkpoint inhibition [comprising either MEDI4736 alone (Cohort A), Tremelimumab (Cohort B) or combined MEDI4736 and Tremelimumab (Cohort C)] in combination with stereotactic body radiation therapy (SBRT) in patients with unresectable pancreatic cancer. Select eligibility criteria are as follows: at least 1 measurable metastatic lesion by RECIST 1.1 criteria and accessible for biopsy. No prior radiation therapy to the pancreas allowed. There is no limit to the number of prior chemotherapy regimens received; ECOG ≤ 1; Life expectancy of greater than 3 months. Acceptable organ and bone marrow function. No active or prior documented autoimmune or inflammatory disorders. Clinical trial information: NCT02311361.
Comparison of Experimental Temperature Results With Numerical Modeling Predictions of a Real-World Compact Data Center Facility (2007)

In this paper we address the high level of validation of commercially available numerical predictive tools, namely CFD models, for data center applications. Experimental data at a real world facility is compared with computational results. Specifically, a recently developed temperature measurement tool is used to capture three dimensional temperature profiles of the facility with very fine spatial granularity. These detailed contours based on actual measurements reveal hot air recirculation patterns in the room as well as variable utilization levels of the room air-conditioning units. We compare these experimental temperature distributions measured using a novel 3D mapping tool with CFD thermal modeling results. An algorithm for generating CFD models for real world systems is proposed and demonstrated. It is found that due to the extensive inaccuracies in rapidly gathered input data as well as inherent limitations of the model, there can be significant discrepancies between predicted and actual temperatures. In addition to steady state measurements, transient data was also collected and are presented. Knowledge of the transient temperature profiles at different parts of the room allows an estimation of the temporal behavior of the data center. Transient temperature fluctuations are presented which capture the real variations in the system boundary conditions, for example the temperature of the chilled water to the air conditioning units, or the power dissipation of the servers over time.
Self-assembled hybrid metal oxide base catalysts prepared by simply mixing with organic modifiers (2015)

Multidentate materials formed by simply mixing heterogeneous and homogeneous components are promising for construction of versatile active sites on the surface of heterogeneous compounds, however, to the best of our knowledge, there are no reports on such materials. Self-assembly of hetero-hybrid catalytic materials occurs when heterogeneous catalysts having adjacent Lewis acid-Lewis base sites are mixed with an organic modifier that contains at least two Lewis base functional groups. Here we demonstrate the strategy by combining cerium oxide and 2-cyanopyridine that self-assembles to form a charge-transfer complex in methanol that exhibits a 2,000-fold increase in reaction rate for hydromethoxylation of acrylonitrile with high selectivity compared with cerium oxide or 2-cyanopyridine alone. The catalytic system is applied to the transesterification and Knoevenagel condensation affording 14-fold and 11-fold higher activity, respectively, than cerium oxide alone. These results demonstrate the potential versatility of the catalytic system and the generality of the catalyst preparation strategy.
Accurate measurement of microbubble response to ultrasound with a diagnostic ultrasound scanner (2015)

Ultrasound and microbubbles are often used to enhance drug delivery and the suggested mechanisms are extravasation and sonoporation. Drug delivery schemes with ultrasound and microbubbles at both low and high acoustic amplitudes have been suggested. A diagnostic ultrasound scanner may play a double role as both an imaging and a therapy device. It was not possible to accurately measure microbubble response with an ultrasound scanner for a large range of acoustic pressures and microbubble concentrations until now, mainly because of signal saturation issues. A method for continuously adjusting the receive gain of a scanner and limiting signal saturation was developed to accurately measure backscattered echoes from microbubbles for mechanical indexes (MIs) up to 2.1. The intensity of backscattered echoes from microbubbles increased quarticly with MI without reaching any limit. The signal intensity from microbubbles was found to be linear with concentration at both low and high MIs. However, at very high concentrations, acoustic shadowing occurs which limits the delivered acoustic pressure in deeper areas. The contrastto- tissue ratio was also measured and found to stay constant with MI. These results can be used to better guide drug delivery approaches and to also develop imaging techniques for therapy procedures.
Accurate Capacitance Modeling and Characterization of Organic Thin-Film Transistors (2014)

This paper presents analysis of the charge storage behavior in organic thin-film transistors (OTFTs) by means of admittance characterization, compact modeling, and 2-D device simulation. The measurements are performed for frequencies ranging from 100 Hz to 1 MHz and bias potentials from zero to -3 V on top-contact OTFTs that employ air-stable and high-mobility dinaphtho-thieno-thiophene as the organic semiconductor. It is demonstrated that the dependence of the intrinsic OTFT gate-source and gate-drain capacitances on the applied voltages agrees very well with Meyer's capacitance model. Furthermore, the impact of parasitic elements, including fringe current and contact impedance, is investigated. The parameters used for the simulation and modeling of all the dynamic characteristics correspond closely to those extracted from static measurements. Finally, the implications of the admittance measurements are also discussed relating to the OTFTs dynamic performance, particularly the cutoff frequency and the charge response time.
<title>Imaging with terahertz pulses</title> (2000)

Recently, a real-time imaging system based on terahertz (THz) time-domain spectroscopy has been developed. This technique offers a range of unique imaging modalities due to the broad bandwidth, sub-picosecond duration, and phase-sensitive detection of the THz pulses. This paper provides a brief introduction of the state-of-the-art in THz imaging. It also focuses on expanding the potential of this new and exciting field through two major efforts. The first concentrates on improving the experimental sensitivity of the system. We are exploring an interferometric arrangement to provide a background-free reflection imaging geometry. The second applies novel digital signal processing algorithms to extract useful information from the THz pulses. The possibility exists to combine spectroscopic characterization and/or identification with pixel-by-pixel imaging. We describe a new parameterization algorithm for both high and low refractive index materials.
ChemInform Abstract: STEREOSELECTIVE PROTONATION OF STABLE CARBANIONS DERIVED FROM 9,10‐DIHYDROPHENANTHRENES (1982)

Abstract Aus den 9‐substituierten 10‐Methyl‐phenanthrenen (I) entstehen mit Li/Ammoniak die isomeren Dihydroverbindungen (II) und (III), deren Konformationen zugeordnet werden.
Construction of a Noninfectious SARS-CoV-2 Replicon for Antiviral-Drug Testing and Gene Function Studies (2021)

The emerging coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread worldwide, resulting in global public health emergencies and economic crises. In the present study, a noninfectious and biosafety level 2 (BSL2)-compatible SARS-CoV-2 replicon expressing a nano luciferase (nLuc) reporter was constructed in a bacterial artificial chromosomal (BAC) vector by reverse genetics. The nLuc reporter is highly sensitive, easily quantifiable, and high throughput adaptable. Upon transfecting the SARS-CoV-2 replicon BAC plasmid DNA into Vero E6 cells, we could detect high levels of nLuc reporter activity and viral RNA transcript, suggesting the replication of the replicon. The replicon replication was further demonstrated by the findings that deleting nonstructural protein 15 or mutating its catalytic sites significantly reduced replicon replication, whereas providing the nucleocapsid protein in <i>trans</i> enhanced replicon replication in a dose-dependent manner. Finally, we showed that remdesivir, a U.S. Food and Drug Administration-approved antiviral drug, significantly inhibited the replication of the replicon, providing proof of principle for the application of our replicon as a useful tool for developing antivirals. Taken together, this study established a sensitive and BSL2-compatible reporter system in a single BAC plasmid for investigating the functions of SARS-CoV-2 proteins in viral replication and evaluating antiviral compounds. This should contribute to the global effort to combat this deadly viral pathogen. <b>IMPORTANCE</b> The COVID-19 pandemic caused by SARS-CoV-2 is having a catastrophic impact on human lives. Combatting the pandemic requires effective vaccines and antiviral drugs. In the present study, we developed a SARS-CoV-2 replicon system with a sensitive and easily quantifiable reporter. Unlike studies involving infectious SARS-CoV-2 virus that must be performed in a biosafety level 3 (BSL3) facility, the replicon is noninfectious and thus can be safely used in BSL2 laboratories. The replicon will provide a valuable tool for testing antiviral drugs and studying SARS-CoV-2 biology.
Disilver: spectroscopy and photoprocesses in rare-gas matrixes (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDisilver: spectroscopy and photoprocesses in rare-gas matrixesSteven A. Mitchell, Geraldine A. Kenney-Wallace, and Geoffrey A. OzinCite this: J. Am. Chem. Soc. 1981, 103, 20, 6030–6035Publication Date (Print):October 1, 1981Publication History Published online1 May 2002Published inissue 1 October 1981https://pubs.acs.org/doi/10.1021/ja00410a007https://doi.org/10.1021/ja00410a007research-articleACS PublicationsRequest reuse permissionsArticle Views76Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The relationship between root hydraulics and scion vigour across Vitis rootstocks: what role do root aquaporins play? (2012)

Vitis vinifera scions are commonly grafted onto rootstocks of other grape species to influence scion vigour and provide resistance to soil-borne pests and abiotic stress; however, the mechanisms by which rootstocks affect scion physiology remain unknown. This study characterized the hydraulic physiology of Vitis rootstocks that vary in vigour classification by investigating aquaporin (VvPIP) gene expression, fine-root hydraulic conductivity (Lp(r)), % aquaporin contribution to Lp(r), scion transpiration, and the size of root systems. Expression of several VvPIP genes was consistently greater in higher-vigour rootstocks under favourable growing conditions in a variety of media and in root tips compared to mature fine roots. Similar to VvPIP expression patterns, fine-root Lp(r) and % aquaporin contribution to Lp(r) determined under both osmotic (Lp(r)(Osm)) and hydrostatic (Lp(r)(Hyd)) pressure gradients were consistently greater in high-vigour rootstocks. Interestingly, the % aquaporin contribution was nearly identical for Lp(r)(Osm) and Lp(r)(Hyd) even though a hydrostatic gradient would induce a predominant flow across the apoplastic pathway. In common scion greenhouse experiments, leaf area-specific transpiration (E) and total leaf area increased with rootstock vigour and were positively correlated with fine-root Lp(r). These results suggest that increased canopy water demands for scion grafted onto high-vigour rootstocks are matched by adjustments in root-system hydraulic conductivity through the combination of fine-root Lp(r) and increased root surface area.
Activation of N-nitrosodialkylamines by near-ultraviolet irradiation: formation of directly-acting mutagens and DNA-damaging products. (1987)

On near-ultraviolet (UVA) irradiation in a phosphate buffer, N-nitrosomorpholine (NMOR) and N-nitrosopyrrolidine (NPYR) were converted into directly-acting mutagens. The activated NPYR was fractionated, and the active product was isolated. The compound was shown to be identical to alpha-phosphonooxy NPYR on the basis of several properties: retention times in high-performance liquid chromatograms, mutagenic specificity and potency, ultraviolet spectrum, and inactivation by phosphatase treatment. Photoactivation was inhibited by superoxide dismutase, and therefore superoxide is implicated as playing a key role in mutagen formation. N-Nitrosoproline (NPRO) and eighteen other N-nitrosodialkylamines were irradiated with UVA in the presence of phi X174 RFI DNA. The DNA underwent single-strand breaks to give RFII DNA, indicating that N-nitrosodialkylamines in general have this property. DNA chain cleavage was inhibited both by superoxide dismutase and hydroxyl-radical scavengers. These results provide new information on the genotoxic mechanism of action of N-nitrosodialkylamines.
Imaging near-field transverse modes of vertical-cavity surface-emitting lasers by near-field scanning optical microscopy. (2004)

We have characterized the oxide-confined vertical-cavity surface-emitting laser (VCSEL) using short-tip, tapping-mode tuning fork near-field scanning optical microscopy (TMTF-NSOM). The near-field radiation patterns of the VCSEL were measured. By comparing the topographic and optical images, we attribute the asymmetric transverse modes to the geometric defect outside the oxide aperture. We also performed spatially resolved spectroscopic imaging over the surface of the VCSEL by coupling NSOM to a spectrometer.
The Effect of Phase Separation on Biphasic Waveform Defibrillation (1993)

It has been hypothesized that the defibrillation efficacy of a biphasic shock is caused by the large change in voltage between the two phases. This study examined the effects of separating the two phases in time thus splitting in half the rapid voltage change at phase reversal. The study was performed in three parts each using six dogs. Part I determined defibrillation thresholds (DFTs) for two exponentially truncated biphasic waveforms (3.5/2 msec and 6/6 msec) with interphase time delays of 0, 1, 2, 3, 4, 6, 8, and 10 msec. In Part II, probability of success curves were generated using an up down method with 15 shocks for each delay for the 3.5/2 msec biphasic waveform with interphase delays of 0, 2, 3, 4, and 5 msec. In Part III, DFTs were determined using a 3.5/2 msec and 6/6 msec biphasic as well as a third waveform that consisted of two sequential 6-msec pulses of the same polarity with interphase delays of 0, 5, 10, 15, 20, 25, 50, and 100 msec. In all three parts the defibrillating cathode was a 6.17 cm2 transvenous spring electrode positioned in the RV apex and the anode was a 113 cm2 cutaneous left chest wall electrode patch. With all waveforms, the trailing edge voltage of the first phase was equal to the negative of the leading edge voltage of the second phase. There was no statistical difference in DFTs or in 50% successful defibrillation points for phase separations from 0 to 6 msec and 0 to 5 msec for Parts I and II, respectively. In Part I there was a significant increase in DFTs for phase separations of 8 and 10 msec compared to a phase separation of 0 msec. In Part III there was no significant difference for separations of 0 and 5 msec; however, there was a significant increase in DFT requirements for separations from 5 to 50 msec, which then decreased with a separation of 100 msec for all three waveforms tested. In conclusion, defibrillation efficacy was unchanged with phase separations up to 6 msec. With phase separation, the rapid voltage change during phase reversal is split in half and, thus, cannot explain the improved efficacy of biphasic waveforms.
Role of autoimmunity in contralateral delayed endolymphatic hydrops. (1994)

Contralateral delayed endolymphatic hydrops is described as the development of fluctuating hearing loss and episodic vertigo in a normal ear years following sensorineural hearing loss in the opposite ear. This condition is a variant of delayed endolymphatic hydrops in which new symptoms of severe episodic vertigo develop years later in an ear that has lost most or all of its hearing. The possible etiologies of these two conditions are unknown and may be different. This report presents seven cases of the contralateral form of this disease and experimental evidence that suggests that these patients may be suffering from the initiation of an autoimmune event directed against the remaining inner ear. In Western blot analysis, their serum was reacted against cow cochlear inner ear antigen preparations, and six of the seven cases had serum antibodies directed against a 68 or a 35-36 kilodalton (kd) molecular weight antigen in contrast to three of 43 normal controls (p < .001 Fisher's exact test), the significance of which had previously been reported for autoimmune inner ear disease.