gebhart/patrepeval huggingface dataset:
Ectoderm-Derived Wnt and Hedgehog Signaling Drive Digit Tip Regeneration (2020)

Barrera, Janos MD; Maan, Zeshaan N. MBBS, MS, MRCS; Foster, Deshka MD; Henn, Dominic MD; Chen, Kellen PhD; Bonham, Clark BS; Januszyk, Michael MD, PhD; Longaker, Michael T. MD, MBA, FACS; Weissman, Irv PhD; Gurtner, Geoffrey C. MD, FACS Author Information
Forced response of bladed disk assemblies - A survey (1998)

This work surveys methods for modeling and analyzing bladed disk assemblies common to gas turbine aircraft. An introduction to symmetric (tuned) bladed disk dynamics is presented, followed by a literature review of studies modeling bladed disks, blade mistuning. and the effect of mistuning forced response. A summary of results is given, and suggestions for future work are made.
Integrative pathway enrichment analysis of multivariate omics data (2020)

Multi-omics datasets represent distinct aspects of the central dogma of molecular biology. Such high-dimensional molecular profiles pose challenges to data interpretation and hypothesis generation. ActivePathways is an integrative method that discovers significantly enriched pathways across multiple datasets using statistical data fusion, rationalizes contributing evidence and highlights associated genes. As part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumor types, we integrated genes with coding and non-coding mutations and revealed frequently mutated pathways and additional cancer genes with infrequent mutations. We also analyzed prognostic molecular pathways by integrating genomic and transcriptomic features of 1780 breast cancers and highlighted associations with immune response and anti-apoptotic signaling. Integration of ChIP-seq and RNA-seq data for master regulators of the Hippo pathway across normal human tissues identified processes of tissue regeneration and stem cell regulation. ActivePathways is a versatile method that improves systems-level understanding of cellular organization in health and disease through integration of multiple molecular datasets and pathway annotations.
Organocatalysis and CH Activation Meet Radical‐ and Electron‐Transfer Reactions (2011)

A radical outlook: Recently published “organocatalytic CH activation reactions” have now been interpreted as base-promoted homolytic substitutions. The addition of an aryl radical to an arene followed by deprotonation (see above) and electron transfer form part of the chain reaction. Although these new results are not conceptual breakthroughs, they could be experimental breakthroughs because they presage new transformations in radical (anion) chemistry.
Synthesis and Properties of Iron(II) and Manganese(II) Complexes Derived from a Topologically Constrained Pentadentate Ligand (2000)

The novel bicyclic pentadentate ligand 5-methyl-1,5,9,24,25-pentaazapentacyclo[7.7.7.5.5]pentacosane11,13,15,18(25),20,22-hexene (L1) has been synthesized. Because of its cross-bridged topology it exhibits a relatively rigid preorganized conformation especially appropriate to complex formation, as shown by the crystal structure of the monoprotonated ligand salt, HL1ClH2O [orthorhombic, P212121, a = 9.4405(5) A, b = 13.3617(5) A, c = 16.710(1) A]. The complexes of L1 with both iron(II) and manganese(II) have been characterized, including the crystal structures of [FeL1CH3CN][FeCL4] and [MnL1Cl][PF6] [monoclinic, P21/n, a = 10.0460(5) A, b = 19.237(9) A, c = 15.6254(8) A, beta = 95.97(2)degrees and a = 7.745(2) A, b = 22.786(4) A, c = 14.639(4) A, beta = 105.074(10)degrees respectively]. The manganese complex is high spin with mueff = 5.96 and theta = 2.5 +/- 0.8 cm(-1), indicating weak ferromagnetic interactions. The reactions of the complexes with tert-butyl hydroperoxide and hydrogen peroxide have been shown by ESR spectroscopy to produce the tert-butyl peroxyl and hydroperoxyl radicals, as evidenced by their spin adducts with the spin traps N,N-dimethyl-1-pyrroline-N-oxide and N-tert-butyl-phenyl-nitrone.
30 Abnormaal uterien bloedverlies (2016)

Bij klachten van abnormaal uterien bloedverlies is voor het stellen van de juiste diagnose opnieuw niet veel nodig. Een zorgvuldige anamnese en een goed uitgevoerd gynaecologisch en transvaginaal echoscopisch onderzoek leveren al veel informatie. Aan
Pyridyl and Furyl Epoxides of More Than 99% Enantiomeric Purities: The Use of a Phosphazene Base (2000)

trans-1-(2-Pyridyl)-, trans-1-(3-pyridyl)-, trans-1(2-furyl)-, and trans-1(3-furyl)-2-phenyl epoxides with enantiomeric purities ranging from 96.8 to 99.8% [in favor of the (+, EtOH)-isomer] are obtained in two steps from pure (R,R,R)-oxathiane which is recovered (85-90%) and reused. The chiral bidentate ligand 2-phenyl-(S)-1-(2-pyridyl)ethanol with 99.6% ee was obtained in three steps and 67% overall isolated yield.
Indolo[3,2‐c]quinoline G‐Quadruplex Stabilizers: a Structural Analysis of Binding to the Human Telomeric G‐Quadruplex (2015)

A library of 5-methylindolo[3,2-c]quinolones (IQc) with various substitution patterns of alkyldiamine side chains were evaluated for G-quadruplex (G4) binding mode and efficiency. Fluorescence resonance energy transfer melting assays showed that IQcs with a positive charge in the heteroaromatic nucleus and two weakly basic side chains are potent and selective human telomeric (HT) and gene promoter G4 stabilizers. Spectroscopic studies with HT G4 as a model showed that an IQc stabilizing complex involves the binding of two IQc molecules (2,9-bis{[3-(diethylamino)propyl]amino}-5-methyl-11H-indolo[3,2-c]quinolin-5-ium chloride, 3 d) per G4 unit, in two non-independent but equivalent binding sites. Molecular dynamics studies suggest that end-stacking of 3 d induces a conformational rearrangement in the G4 structure, driving the binding of a second 3 d ligand to a G4 groove. Modeling studies also suggest that 3 d, with two three-carbon side chains, has the appropriate geometry to participate in direct or water-mediated hydrogen bonding to the phosphate backbone and/or G4 loops, assisted by the terminal nitrogen atoms of the side chains. Additionally, antiproliferative studies showed that IQc compounds 2 d (2-{[3-(diethylamino)propyl]amino}-5-methyl-11H-indolo[3,2-c]quinolin-5-ium chloride) and 3 d are 7- to 12-fold more selective for human malignant cell lines than for nonmalignant fibroblasts.
NicPic: Scalable and Accurate End-Host Rate Limiting. (2013)

The degree of multiplexing in datacenters necessitates careful resource scheduling, and network bandwidth is no exception. Unfortunately, today we are left with little control to accurately schedule network traffic with low overhead on end-hosts. This paper presents NicPic, a system which enables accurate network traffic scheduling in a scalable fashion. The key insight in NicPic is to decouple the responsibility of state-management and packet scheduling between the CPU and the NIC, respectively. The CPU is only involved in classifying packets, enqueueing them in per-class queues maintained in host memory, and specifying rate limits for each traffic class. The NIC handles packet scheduling and transmission on a real-time basis. In this paper, we present the design of NicPic which offers a scalable solution for transmit scheduling in future high speed NICs. 1
Supercooled liquid, bulk glassy and nanocrystalline states of alloys : symposium held November 27-30, 2000, Boston, Massachusetts, U.S.A. (2001)

Since nanocrystallites are often formed as a product of devitrification of metallic glasses, and supercooled liquid plays an essential role in bulk glass formation, recent research pertaining to these three states of alloys were brought together for discussion into a single MRS symposium. Bulk glassy and bulk nanocrystalline alloys are important because they demonstrate exclusively good static and dynamic mechanical properties, magnetic properties, and good corrosion and wear resistance. Some of these alloys also exhibit superplasticity, including high-strain-rate flowability. The reports in this book span formation and processing methods of bulk glassy, nanocrystalline alloys; glass- forming ability and thermal stability; devitrification and phase transformations; properties; general physical, mechanical, magnetic, electrical, and corrosion resistance; structure of bulk glasses; supercooled liquid and nanomaterials; and diffusion. Topics include: atomic and electronic structure; glass-forming ability and thermal stability; crystallization and decomposition; quasicrystals; soft magnetic properties; hard magnetism and mechanical and other properties.
Oxidative modification of tropomyosin and myocardial dysfunction following coronary microembolization (2006)

Myofibrillar protein oxidation may represent a mechanistic link between inflammation and contractile dysfunction following coronary microembolization.
Ultrasonic investigation of solute-solvent and solute-solute interactions in aqueous solutions of bases, nucleosides, and nucleotides. 1. Dependence of solute-solvent interactions on the chemical structure of bases, nucleosides, and nucleotides (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUltrasonic investigation of solute-solvent and solute-solute interactions in aqueous solutions of bases, nucleosides, and nucleotides. 1. Dependence of solute-solvent interactions on the chemical structure of bases, nucleosides, and nucleotidesA. P. Sarvazyan, V. A. Bukin, and Paul HemmesCite this: J. Phys. Chem. 1980, 84, 7, 692–696Publication Date (Print):April 1, 1980Publication History Published online1 May 2002Published inissue 1 April 1980https://pubs.acs.org/doi/10.1021/j100444a002https://doi.org/10.1021/j100444a002research-articleACS PublicationsRequest reuse permissionsArticle Views104Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Experimental study of transition to turbulence in steady flow through rigid models of abdominal aortic aneurysms (2002)

As an investigation into the mechanical factors which contribute to aneurysm growth and rupture, flow field measurements for steady flow are presented for a range of Reynolds numbers. Steady flow through rigid aneurysm models with roughly elliptical geometry is studied. Data is reported for a model of length 4d and diameter 2.5d, where d is the inner diameter of the entrance tube. Flow rates were chosen such that model Reynolds numbers matched in vivo Reynolds numbers for a range of subject activity level from resting to highly active. Laser-Doppler velocimetry (LDV) was used to verify flow patterns visualized with CDFI, and to quantify the flow velocities during laminar, transition and turbulent flow regimes. A well defined core flow was observed for all Reynolds numbers studied. The observed flow as laminar at Re=450 and Re=1300, and a stable recirculation zone occurred outside the core flow. Turbulent flow was observed at Re=2800 and no recirculation was seen in this case. This investigation represents an initial step in a more extensive study of flow fields within abdominal aortic aneurysms, the results of which will have significant implications for clinical decisions concerning the treatment of aortic aneurysms.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Toward a Green and Sustainable Chemistry Education Road Map (2020)

Although principles and practices of green and sustainable chemistry have been articulated for more than 20 years, they have yet to become systemically infused into the undergraduate chemistry curriculum. The American Chemical Society Green Chemistry Institute (ACS GCI) has convened stakeholders from across the chemistry education community to develop a strategy and, subsequently, a road map for mainstreaming green and sustainable chemistry concepts and practices into the chemistry curriculum. Through this initiative, a set of core competencies were developed to guide infusion of green and sustainable chemistry knowledge and skills into the curriculum and prepare chemists to make significant contributions to sustainability in the future. The core competencies are described briefly here as well as strategic efforts to develop the road map and to aid the adoption of green and sustainable chemistry into the undergraduate chemistry curriculum.
Role of portal insulin delivery in the disappearance of intravenous glucose and assessment of insulin sensitivity. (1998)

The contribution of portal insulin delivery to the disappearance of glucose administered intravenously was assessed in the present study. Paired insulin-modified intravenous glucose tolerance tests (IVGTTs) were performed in dogs in which insulin was administered into the portal vein or into a peripheral vein. Peripheral insulin levels were matched in the paired IVGTTs by adjusting the portal insulin dose in proportion to first-pass hepatic insulin extraction. Two sets of IVGTTs were performed. In the first set, hepatic insulin extraction was assumed to be 50% (insulin doses of 0.03 U/kg portal and 0.015 U/kg peripheral; n = 6); in the second set, the assumed extraction rate was reduced to 33% (0.0225 U/kg portal and 0.015 U/kg peripheral; n = 8). In the second set of experiments, a control "zero" dose (no insulin injection) was also performed. For these latter three IVGTTs, the exogenous glucose bolus was labeled with 3-[3H]glucose (25 microCi) to separately assess insulin's effects on the rate of glucose disappearance (Rd) and endogenous glucose production (EGP). For the paired IVGTT based on 33% extraction, the area under the insulin curves after the portal insulin injection was within 2% of that observed with peripheral insulin injection (1,820 +/- 711 vs. 1,791 +/- 661 microU/ml min; P = 0.79). For these conditions, neither the glucose profiles nor the minimal model estimate of insulin sensitivity (S(I)) was significantly influenced by the higher portal insulin delivery (S(I): 3.69 +/- 0.56 vs. 3.35 +/- 0.60 10(-4) min(-1) per microU/ml; portal vs. peripheral; P > 0.05). Analysis of the 3-[3H]glucose tracer dynamics failed to reveal any differences in the portal versus peripheral insulin effect on glucose disappearance or production. We conclude that portal insulin delivery per se does not significantly affect insulin's ability to normalize plasma glucose during acute glucose challenges.
Magnetostrictive Particulate Composites for Damping (2001)

Abstract : The objective of this research effort was to develop a new passive smart damping material applicable to a wide range of aerospace structures. We believe that this innovative damping technology is defining a new standard for the field based primarily on the research conducted under this grant. The novel damping approach absorbs energy using domain wall/detwinning concepts dependent upon stress amplitude and independent of vibrational frequency. This new approach was dramatically different than either viscoelastic materials that are frequency dependent and thermally limited or active approaches that require power supplies and external control electronics. As shown in Figure 1 (from Brodt and Lakes) the new materials investigated at UCLA had both large stiffness and large tan delta unlike traditional materials that either had high stiffness with low tan delta (e.g metals or graphite epoxy composites) or low stiffness with high tan delta (e.g. elastomers). The research conducted under this grant helped the scientific community understand some basic physical properties of a wide range of materials under varying thermal-mechanical-magnetic-electrical loading conditions. This research effort was designed to develop a fundamental understanding for these new smart materials.
Sampling for unsupervised domain adaptive object detection (2013)

We explore the problem of extreme class imbalance present when performing fully unsupervised domain adaptation for object detection. The main challenge arises from the fact that images in unconstrained settings are mostly occupied by the background (negative class). Therefore, random sampling will not typically result in a sufficient number of positive samples from the target domain, which is required by domain adaptation methods. Motivated by traditional semi-supervised learning algorithms that aim for better classification using both labeled and unlabeled data, we propose a variation of co-learning technique that automatically constructs a more balanced set of samples from the target domain. We evaluate the effectiveness of our approach using a vehicle detection task in an urban surveillance dataset. Furthermore, we compare the performance of our technique with two other approaches-one based on unbiased learning on multiple training data sets and the other on self-learning.
Attenuation of Mycobacterium tuberculosis by Disruption of a mas -Like Gene or a Chalcone Synthase-Like Gene, Which Causes Deficiency in Dimycocerosyl Phthiocerol Synthesis (2003)

Tuberculosis is one of the leading preventable causes of death. Emergence of drug-resistant tuberculosis makes the discovery of new targets for antimycobacterial drugs critical. The unique mycobacterial cell wall lipids are known to play an important role in pathogenesis, and therefore the genes responsible for their biosynthesis offer potential new targets. To assess the possible role of some of the genes potentially involved in cell wall lipid synthesis, we disrupted a mas-like gene, msl7, and a chalcone synthase-like gene, pks10, with phage-mediated delivery of the disruption construct, in which the target gene was disrupted by replacement of an internal segment with the hygromycin resistance gene (hyg). Gene disruption by allelic exchange in the case of each disruptant was confirmed by PCR and Southern blot analyses. Neither msl7 nor pks10 mutants could produce dimycocerosyl phthiocerol, although both could produce mycocerosic acids. Thus, it is concluded that these gene products are involved in the biosynthesis of phthiocerol. Both mutants were found to be attenuated in a murine model, supporting the hypothesis that dimycocerosyl phthiocerol is a virulence factor and thus the many steps involved in its biosynthesis offer potential novel targets for antimycobacterial therapy.
A reasoning approach to enable abductive semantic explanation upon collected observations for forensic visual surveillance (2011)

This paper proposes an approach to enable automatic generation of probable semantic hypotheses for a given set of collected observations for forensic visual surveillance. As video analytic power exploited in visual surveillance is getting matured, the more automatically generated intermediate semantic metadata became available. In the sense of forensic reuse of such data, the majority of approaches have been focused on specific semantic query based scene analysis. However, in reality, there are often cases in which it is more natural to reason about the most probable semantic explanation of a scene given a collection of specific semantic evidences. In general, this type of diagnostic reasoning is known as abduction. To enable such a semantic reasoning, in this paper, we propose a layered reasoning pipeline that combines abductive logic programming together with backward and forward chaining based deductive logic programming. To rate derived hypotheses, we apply subjective logic. We present a conceptual case study in a distributed camera based scenario. The case study shows the potential and feasibility of the proposed approach for forensic analysis of visual surveillance data.
Chaos in microwave antenna arrays (2002)

This paper considers a chaotic microwave transmitter consisting of a quasi-optical antenna array. When the coupling strength between array elements is too small to allow phase-locking, the antenna arrays exhibit low-dimensional chaos. These arrays show potential for use in inexpensive, high-power and high-speed wireless communication channels.
Dominant B-cell epitopes from cancer/stem cell antigen SOX2 recognized by serum samples from cancer patients. (2014)

Human sex determining region Y-box 2 (SOX2) is an important transcriptional factor involved in the pluripotency and stemness of human embryonic stem cells. SOX2 plays important roles in maintaining cancer stem cell activities of melanoma and cancers of the brain, prostate, breast, and lung. SOX2 is also a lineage survival oncogene for squamous cell carcinoma of the lung and esophagus. Spontaneous cellular and humoral immune responses against SOX2 present in cancer patients classify it as a tumor-associated antigen (TAA) shared by lung cancer, glioblastoma, and prostate cancer among others. In this study, B-cell epitopes were predicted using computer-assisted algorithms. Synthetic peptides based on the prediction were screened for recognition by serum samples from cancer patients using ELISA. Two dominant B-cell epitopes, SOX2:52-87 and SOX2:98-124 were identified. Prostate cancer, glioblastoma and lung cancer serum samples that recognized the above SOX2 epitopes also recognized the full-length protein based on Western blot. These B-cell epitopes may be used in assessing humoral immune responses against SOX2 in cancer immunotherapy and stem cell-related transplantation.
Supplementary Data from Adhesive Interactions Regulate Transcriptional Diversity in Malignant B Cells (2023)

Supplementary Data from Adhesive Interactions Regulate Transcriptional Diversity in Malignant B Cells
Shared interactive video for teleconferencing (2003)

We present a system that allows remote and local participants to control devices in a meeting environment using mouse or pen based gestures "through" video windows. Unlike state-of-the-art device control interfaces that require interaction with text commands, buttons, or other artificial symbols, our approach allows users to interact with devices through live video of the environment. This naturally extends our video supported pan/tilt/zoom (PTZ) camera control system, by allowing gestures in video windows to control not only PTZ cameras, but also other devices visible in video images. For example, an authorized meeting participant can show a presentation on a screen by dragging the file on a personal laptop and dropping it on the video image of the presentation screen. This paper presents the system architecture, implementation tradeoffs, and various meeting control scenarios.
Towards cross-layer telemetry (2021)

This paper introduces Cross-Layer Telemetry (Clt), a way to combine in-band telemetry (based on In-Situ Oam) and Application Performance Management (APM, based on distributed tracing) into a single monitoring tool providing a full network stack observability. Using Clt, APM traces are correlated with network telemetry information, providing a better view and faster root cause analysis in case of issue. In this paper, we describe the Clt implementation and discuss a use case demonstrating its efficiency. All Clt source code is available as open source.