gebhart/patrepeval huggingface dataset:
Electronic spin of the ground state of m-naphthoquinomethane, a non-Kekule molecule with nondegenerate Hueckel nonbonding molecular orbitals (NBMOs) (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic spin of the ground state of m-naphthoquinomethane, a non-Kekule molecule with nondegenerate Hueckel nonbonding molecular orbitals (NBMOs)David E. Seeger, Edwin F. Hilinski, and Jerome A. BersonCite this: J. Am. Chem. Soc. 1981, 103, 3, 720–721Publication Date (Print):February 1, 1981Publication History Published online1 May 2002Published inissue 1 February 1981https://pubs.acs.org/doi/10.1021/ja00393a062https://doi.org/10.1021/ja00393a062research-articleACS PublicationsRequest reuse permissionsArticle Views101Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Low-Volume PFC Rectifier Based on Nonsymmetric Multilevel Boost Converter (2014)

This paper introduces a digitally controlled single-phase rectifier with power factor correction (PFC) based on a modified three-level boost converter topology. In comparison with the conventional boost-based systems, the new PFC rectifier has about three times smaller inductor and significantly lower switching losses. The improvements are achieved by replacing the output capacitor of the boost converter with a nonsymmetric active capacitive divider, with a 3:1 division ratio, and by utilizing the downstream converter stage for the capacitive divider's center-tap voltage regulation. The nonsymmetric voltage divider and applied switching sequence effectively provide four-level converter behavior using the same number of components as three-level converters. As a result, a 66% reduction of the inductor compared to the conventional boost-based PFC and a 33% compared to the standard three-level solutions operating at the same effective switching frequencies are also achieved. Experimental results obtained with a 400 W, 200 kHz, universal input voltage (85 V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> -265 V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> ) PFC prototype demonstrate three times smaller inductor current ripple than that of the conventional boost converter allowing for the same inductor reduction. Efficiency improvements of up to a 6% are also demonstrated.
Recovery dynamics of a PbS quantum dot doped glass passive mode locker (2003)

Summary form only given. Recently we demonstrated that PbS quantum dot doped glasses, fabricated by thermal treatment of an oxide molten glass, can be used as intracavity saturable absorbers to obtain self-starting mode locking in infrared solid-state lasers. In particular, using these absorbers in a Cr:forsterite laser we obtained pulses as short as 4.6 ps with a time-bandwidth product of 0.35 and pulse energies up to 1 nJ. Because of the large exciton Bohr radius (18 nm) and the small band gap energy (0.4 meV at RT) these saturable absorbers are suitable for operation over a wide spectral rang from visible to 3 /spl mu/m. However, it was unclear why shorter pulses then 4.6 ps could not be obtained. Here we perform degenerate pump-probe experiments to address this point and determine the recovery time of the optical nonlinearity.
Effects of tetracycline on antibiotic resistance and removal of fecal indicator bacteria in aerated and unaerated leachfield mesocosms (2007)

Antibiotics can be present in low concentrations in domestic wastewater, but little is known about their effect on bacteria in onsite wastewater treatment systems. Mesocosms, consisting of soil-filled lysimeters representing the leachfield of a septic system under aerated (AIR) and unaerated (LEACH) conditions, were used to study the effects of tetracycline addition (5 mg L(-1)) to septic tank effluent on tetracycline resistance in the fecal indicator bacteria Escherichia coli and fecal streptococci, and on their removal. The mesocosms were dosed with antibiotic for 10 days, and effects monitored for 52 days. The fraction of resistant bacteria in mesocosm drainage water relative to that in septic tank effluent, GammaRes, for E. coli ranged from 0 to 0.66 in the AIR treatment and from 0 to 3.32 in the LEACH treatment. For fecal streptococci, GammaRes ranged from 0 to 0.41 and from 0.63 to 1.06 in the AIR and LEACH treatments, respectively. No significant differences in antibiotic resistance of fecal indicator bacteria were observed among sampling dates in soil or water from either treatment. Tetracycline had no significant effect on removal of fecal indicator bacteria, which ranged from 99.9 to 100% for E. coli and from 95.9 to 100% for fecal streptococci. Our results suggest that short-term addition of tetracycline at environmentally-relevant concentrations is likely to have minimal consequences on pathogen removal from wastewater and development of antibiotic resistance among pathogenic bacteria in leachfield soil.
Semiconductor electrodes. 13. Characterization and behavior of n-type zinc oxide, cadmium sulfide, and gallium phosphide electrodes in acetonitrile solutions (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSemiconductor electrodes. 13. Characterization and behavior of n-type zinc oxide, cadmium sulfide, and gallium phosphide electrodes in acetonitrile solutionsP. A. Kohl and A. J. BardCite this: J. Am. Chem. Soc. 1977, 99, 23, 7531–7539Publication Date (Print):November 1, 1977Publication History Published online1 May 2002Published inissue 1 November 1977https://doi.org/10.1021/ja00465a023RIGHTS & PERMISSIONSArticle Views848Altmetric-Citations96LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
Nanocall: An Open Source Basecaller for Oxford Nanopore Sequencing Data (2016)

ABSTRACT Motivation The highly portable Oxford Nanopore MinlON sequencer has enabled new applications of genome sequencing directly in the field. However, the MinlON currently relies on a cloud computing platform, Metrichor (metrichor.com), for translating locally generated sequencing data into basecalls. Results To allow offline and private analysis of MinlON data, we created Nanocall. Nanocall is the first freely-available, open-source basecaller for Oxford Nanopore sequencing data and does not require an internet connection. On two E.coli and two human samples, with natural as well as PCR-amplified DNA, Nanocall reads have ~68% identity, directly comparable to Metrichor ”1D” data. Further, Nanocall is efficient, processing ~500Kbp of sequence per core hour, and fully parallelized. Using 8 cores, Nanocall could basecall a MinlON sequencing run in real time. Metrichor provides the ability to integrate the ”1D” sequencing of template and complement strands of a single DNA molecule, and create a ”2D” read. Nanocall does not currently integrate this technology, and addition of this capability will be an important future development. In summary, Nanocall is the first open-source, freely available, off-line basecaller for Oxford Nanopore sequencing data. Availability Nanocall is available at github.com/mateidavid/nanocall , released under the MIT license. Contact matei.david at oicr.on.ca
High-performance organic field-effect transistors, textured by self-assembly (2009)

Some of these crystals also represent problem cases as the ensuing crystals are generally small and extremely prone for different kinds of twinning. Still, a first classification of such systems seems to be feasible. Results of these investigations will be reported concurrently.
Controlling Response of Polyaniline Towards Humidity by Self-Assembly Fatty Acids (2022)

Conductive polymers based sensors are potentially a powerful tool for detecting a variety of analytes in gas phase. However, the accuracy and reliability of such sensors are threatened by the humidity interference, which limits their use in demanding applications, e.g., air-quality monitoring and health care. Thus, there is an urgent need to suppress the response of conductive polymers to humidity. In this work, the surface of polyaniline (PANI) was modified by fatty acid to block the proton exchange between water molecules and PANI polymer chains and thus suppress the humidity response towards PANI based gas sensors. The results show that the humidity response suppression effect is depending on the chain length of surface modified alkyl acid. The long chain alkyl acid modified PANI sensors exhibit strong suppression of the humidity sensing response; while the short chain modified PANI sensors have weak suppression of the humidity sensing response. In specific, the Behenic acid modified PANI sensors have a concentration depend water vapor response as low as 0.008%/ppm, which is only 1/5 of the unmodified PANI sensors. This work might be a valuable example of the humid interferon suppression for other chemical sensors.
Low stroke rate and few thrombo-embolic events after HeartMate II implantation under mild anticoagulation (2012)

Compared with the literature, even a mild anticoagulation protocol does not increase the risk of thrombotic events, but reduces bleeding events in the use of an HM II LVAD.
Immune checkpoint inhibitors in oncology (2021)

Immune checkpoint inhibitors in oncology.Cancer immunotherapy has revolutionized oncology. It results from a long history that went along with that of immunology, with its hesitations and failures, and which led to two complementary approaches. One consists in manufacturing cancer-specific monoclonal antibodies or cytotoxic T cells that are injected into patients. The other consists in relieving control mechanisms that prevent normally immune effectors from being pathogenic, and thus, freeing anti-cancer immunity from its constraints. These immune checkpoint inhibitors proved markedly efficient, especially in cancers with a poor prognosis. They opened an unprecedented increase in novel immunotherapeutic approaches and clinical trials.
A minimax approach for mean square denoising (2005)

Minimax estimation aims at finding optimal estimators in the worst case situation compatible with the available information. In the present work, we consider the minimax mean square denoising of a random vector using a nonlinear estimator. The data set over which the minimax estimator is looked for takes the general form of a convex set where the correlation matrix of the data is constrained to lie. Also, additional convex constraints on the weights defining the estimator can be taken into account in the proposed approach.
[Sleep structure in relation to respiration and heart rate in children in puberty]. (1996)

The different expression of respiratory sinus arrhythmia in REM- versus nonREM-sleep indicates a dependence of cardiorespiratory interaction on patterns of sleep. Investigations of the intensity of respiratory entrainment on heart rhythmicity during various stages of sleep will provide an insight into the coupling of cardiorespiratory interaction and sleep patterns. 42 healthy children (12 to 15 years old) were polygraphically investigated over 24 h. An ECG, EOG, and actogram were performed, respiratory movements were observed, and the skin temperature was taken. The power spectra of the instantaneous heart rate and the respirograms were calculated. The analysis of coherence was carried out to determine how pronounced the cardiorespiratory interaction is. REM-sleep, nonREM-phases, and wakefulness were compared. The spectral parameters of instantaneous heart rate show differences between both stages of sleep and the waking state. Due to a dependence of spectral power on breathing patterns, drawing quantitative conclusions is not possible. The analysis of coherence provides more information about sleep patterns within the cardiorespiratory interaction. It is very pronounced during non-REM-sleep (0.80 +/- 0.07; mean +/- standard deviation). Heart rhythmicity proceeds independent of breathing during REM-sleep (0.52 +/- 0.11). The coupling is weaker than during wakefulness (0.64 +/- 0.09).
Tandem triad systems based on FRET for two-photon induced release of glutamate (2013)

Tandem systems allowing enhanced two-photon (2P) absorption in a wavelength range permitting coupling of the primary excitation by energy transfer to an intramolecular cage known to have fragmentation properties suited to photolysis in neuroscience is demonstrated to lead to a 10-fold improvement in the 2P photolysis cross-section at experimentally compatible wavelengths.
Safety Performance of Large and High-Power Lithium-Ion Batteries with Manganese Spinel and Meso Carbon Fiber (2007)

Three different-sized lithium-ion cells for hybrid electric vehicles nominal capacity 5, 8, and , were fabricated using lithium-rich mangnese spinel (LM) as a positive active material and meso carbon fiber (MCF) as a negative active material. Overcharge tests at about 5, 16, 100 and current were carried out to estimate a safety level of LM/MCF cells. As a result of the overcharge test, all cells were not fired and did not burst and themal runaway of the 5 and cells did not occur at 1C rate. LM/MCF cells have great ability for safety under high-rate overcharge. However, thermal runaway occurred at 12C–40C rate overcharge. Thermal runaway depends strongly on the C rate at overcharge.
Haemoglobin wrapped covalently by human serum albumin mutants containing Mn(iii) protoporphyrin IX: an O2complex stable in H2O2solution (2014)

We describe the synthesis of a haemoglobin (Hb) wrapped covalently by recombinant human serum albumin mutants [HSA(Y161H)] containing Mn(III) protoporphyrin IX (MnPP), the Hb-[HSA(Y161H)-MnPP]3 cluster, highlighting the formation of its O2-complex stable even in H2O2 solution.
Superoxide dismutase 1 protects retinal cells from oxidative damage (2006)

Bolstering the endogenous oxidative damage defense system is a good strategy for development of treatments to combat neurodegenerative diseases in which oxidative damage plays a role. A first step in such treatment development is to determine the role of various components of the defense system in cells that degenerate. In this study, we sought to determine the role of superoxide dismutase 1 (SOD1) in two models of oxidative damage-induced retinal degeneration. In one model, paraquat is injected into the vitreous cavity and then enters retinal cells and generates reactive oxygen species (ROS) that cause progressive retinal damage. Assessment of retinal function with serial electroretinograms (ERGs) showed that sod1 -/- mice were much more sensitive than sod1 +/+ mice to the damaging effects of paraquat, while sod1 +/- mice showed intermediate sensitivity. Compared to sod1 +/+ mice, sod1 -/- mice showed greater paraquat-induced oxidative damage and apoptosis. In the second model, mice were exposed to hyperoxia for several weeks, and sod1 -/- mice showed significantly greater reductions in ERG amplitudes than sod1 +/+ mice. In both of these models, transgenic mice carrying a sod1 transgene driven by a beta-actin promoter showed less oxidative stress-induced reduction in ERG amplitudes. These data demonstrate that SOD1 protects retinal cells against paraquat- and hyperoxia-induced oxidative damage and suggest that overexpression of SOD1 should be considered as one component of ocular gene therapy to prevent oxidative damage-induced retinal degeneration.
A biosensor generated via high-throughput screening quantifies cell edge Src dynamics (2020)

Fluorescent biosensors for living cells currently require laborious optimization and a unique design for each target. They are limited by the availability of naturally occurring ligands with appropriate target specificity. Here we describe a biosensor based on an engineered fibronectin monobody scaffold that can be tailored to bind different targets via high throughput screening. This Src family kinase (SFK) biosensor was made by derivatizing a monobody specific for activated SFK with a bright dye whose fluorescence increases upon target binding. We identified sites for dye attachment and alterations to eliminate vesiculation in living cells, providing a generalizable scaffold for biosensor production. This approach minimizes cell perturbation because it senses endogenous, unmodified target, and because sensitivity is enhanced by direct dye excitation. Automated correlation of cell velocities and SFK activity revealed that SFK are activated specifically during protrusion. Activity correlates with velocity, and peaks 1–2 microns from the leading edge.
A systems approach to evolutionary multiobjective structural optimization and beyond (2009)

Multiobjective evolutionary algorithms (MOEAs) have shown to be effective in solving a wide range of test problems. However, it is not straightforward to apply MOEAs to complex real-world problems. This paper discusses the major challenges we face in applying MOEAs to complex structural optimization, including the involvement of time-consuming and multi-disciplinary quality evaluation processes, changing environments, vagueness in formulating criteria formulation, and the involvement of multiple sub-systems. We propose that the successful tackling of all these aspects give birth to a systems approach to evolutionary design optimization characterized by considerations at four levels, namely, the system property level, temporal level, spatial level and process level. Finally, we suggest a few promising future research topics in evolutionary structural design that consist in the necessary steps towards a life-like design approach, where design principles found in biological systems such as self-organization, self-repair and scalability play a central role.
Model-Driven Deep Learning Method for Jammer Suppression in Massive Connectivity Systems (2019)

We present a method for separating collided signals from multiple users in the presence of strong and wideband interference/jamming signal. More specifically, we consider a massive connectivity setup where few, out of a large number of users, equipped with spreading codes, synchronously transmit symbols. The received signal is a noisy mixture of symbols transmitted through users' flat fading channels, impaired by fast frequency hopping jamming signal of relatively large power. In the absence of any conventional technique suitable for the considered setup, we propose a "model-driven" deep learning method, based on convolution neural network, to suppress jamming signal from the received signal, and detect active users together with their transmitted symbols. A numerical study of the proposed method confirms its effectiveness in scenarios where classical techniques fail. As such, in a two user scenario with wideband jamming signal of power $20$ dB above the power any active user, the proposed algorithm achieves error rates $10^{-2}$ for a wide range of AWGN variances.
Mechanical Comparison of Small Interlocking Nail Systems in Torsion Using A Feline Bone Model Surrogate (2019)

Introduction: Traditionally, plate osteosynthesis was the preferred fixation method of for feline long-bone fractures. Recently, two angle-stable interlocking nails suitable for cats were introduced, but objective comparison of these nails has yet to be performed. Our null hypotheses were that for both phases, there would be no significant difference in outcome measures among groups.
Photonic Metamaterials: Introduction (2007)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Evgenii E. Narimanov, Vladimir M. Shalaev, and Azriel Z. Genack, "Photonic Metamaterials: Introduction," J. Opt. Soc. Am. B 24, PM1-PM2 (2007) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Contact and Channel 3rd-Order Nonlinearity in III-N HFETs (2011)

A novel technique to reveal the contact and channel components of third-order nonlinearities in III-nitride heterostructure field-effect transistors (HFETs) is presented. We demonstrate close correspondence between the third-order intermodulation power (IM3) obtained from dc I-V's and directly from two-tone radio-frequency measurements. The transmission-line-method patterns have been used to extract separately the contact- and channel-related sources of nonlinearity. Relative contributions of mobility-field dependence and gate-bias-induced nonlinearities are compared. Contact and channel nonlinearity coefficients are found to have opposite signs, thus allowing for HFET design with contact and channel nonlinearities mutually compensating each other, which results in improved overall device linearity.
CACHE (Critical Assessment of Computational Hit-finding Experiments): A public-private partnership benchmarking initiative to enable the development of computational methods for hit-finding (2021)

Computational approaches in drug discovery and development hold great promise, with artificial intelligence methods undergoing widespread contemporary use, but the experimental validation of these new approaches is frequently inadequate. We are initiating Critical Assessment of Computational Hit-finding Experiments (CACHE) as a public benchmarking project that aims to accelerate the development of small molecule hit-finding algorithms by competitive assessment. Compounds will be identified by participants using a wide range of computational methods for dozens of protein targets selected for different types of prediction scenarios, as well as for their potential biological or pharmaceutical relevance. Community-generated predictions will be tested centrally and rigorously in an experimental hub(s), and all data, including the chemical structures of experimentally tested compounds, will be made publicly available without restrictions. The ability of a range of computational approaches to find novel compounds will be evaluated, compared, and published. The overarching goal of CACHE is to accelerate the development of computational chemistry methods by providing rapid and unbiased feedback to those developing methods, with an ancillary and valuable benefit of identifying new compound-protein binding pairs for biologically interesting targets. The initiative builds on the power of crowd sourcing and expands the open science paradigm for drug discovery.