gebhart/patrepeval huggingface dataset:
A functional monoclonal antibody recognizing the human alpha 1‐integrin I‐domain (1996)

Alpha 1 beta 1 heterodimer is a member of the integrin receptor superfamily that has been described to be involved in cell-matrix binding through its interaction with collagens, fibronectin and laminin. The alpha 1 integrin belongs to a subset of I-domain containing integrins that includes alpha M, alpha L, alpha X and alpha 2. In this study we describe an anti-alpha 1 mAb (FB12) that recognizes an epitope located in the human alpha 1 I-domain, since the mAb can bind to human, but not to rat, recombinant I-domain GST fusion protein. FB12 mAb efficiently and specifically inhibits the binding of activated human lymphocytes to laminin, collagen and fibronectin. These data support the notion that the alpha 1 I-domain itself has an important role in receptor-ligand binding. In particular, we show that alpha 1 integrin-dependent lymphocyte adhesion to fibronectin is I-domain mediated, at variance with the RGD-dependent adhesion which seems to be mediated by the beta 1 rather than the alpha 1 integrin chain. Lastly, the overexpression of the alpha 1-integrin by stromal cells and blood vessels of solid tumors may suggest a role for this integrin in tumor biology.
The canonical controller and its regularity (2004)

This paper deals with properties of canonical controllers. We first specify the behavior that they implement. It follows that a canonical controller implements the desired controlled behavior if and only if the desired behavior is implementable. We subsequently investigate the regularity of the controlled behavior. We prove that a canonical controller is regular if and only if every controller is regular. In other words, canonical controllers are maximally irregular.
ChemInform Abstract: Exploration of New Superconductors and Functional Materials and Fabrication of Superconducting Tapes and Wires of Iron Pnictides (2015)

Abstract Review: 536 refs.
Computational methods for the optimisation and design of electromechanical vehicle systems (2012)

The development of advanced electromechanical vehicle systems requires the consideration of multiple physical processes including electromagnetics, fluid flow, heat transfer, and structural mechanics. Accordingly, this paper presents a suite of simulation, optimisation, and design strategies that may be applied to the research and development of modern electric and hybrid-electric vehicles. These computational methods are illustrated through three examples that involve electric motors and electronic systems. Two and three-dimensional topology optimisation studies, parametric geometry sweeps, and multi-scale models are shown to inform unique designs prior to the fabrication and testing of advanced prototypes. It is expected that such computational techniques will have a significant impact on the development of highly efficient future ground transportation systems.
Air-Heating Solar Collectors for Humidification-Dehumidification Desalination Systems (2010)

Relative to solar water heaters, solar air heaters have received relatively little investigation and have resulted in few commercial products. However, in the context of a Humidification-Dehumidification (HDH) Desalination cycle, air heating accounts for advantages in cycle performance. Solar collectors can be over 40% of an air-heated HDH system’s cost, thus design optimization is crucial. Best design practices and sensitivity to material properties for solar air heaters are investigated, and absorber solar absorptivity and glazing transmissivity are found to have the strongest effect on performance. Wind speed is also found to have an impact on performance. Additionally a well designed, and likely low cost, collector includes a double glazing and roughened absorber plates for superior heat transfer to the airstream. A collector in this configuration performs better than current collectors with an efficiency of 58% at a normalized gain of 0.06 K m2/W.
Après les régionales, 'le retour à la terre' (Interview) (2015)

Premier paragraphe :\nAprès le scrutin de dimanche, plusieurs élus, à commencer par les futurs présidents de conseils régionaux Xavier Bertrand ou Christian Estrosi, ont décidé de démissionner de leur mandat de députés et de maires. Mais, au-delà de la question du non-cumul des mandats, ce choix semble plus pragmatique que politique.\n\nDécrit comme un "plouc de province" par ses détracteurs cités par Le Parisien de mercredi, Xavier Bertrand assume. Il mange avec ses doigts, regardeIntervilles, écouteLes Enfoirés. "Populaire mais pas populiste" selon ses proches, le futur président de la région Nord-Pas-de-Calais-Picardie va démissionner de son poste de député-maire de Saint-Quentin (Aisne) et abandonner la course à la primaire de droite pour mieux se consacrer à son mandat local. Il n'est pas le seul : d'autres patrons des nouvelles régions, Christian Estrosi, Valérie Pécresse ou encore Hervé Morin, vont l'imiter. Tout comme quelques simples conseillers régionaux, comme Gérald Darmanin dans le Nord ou François Sauvadet en Côte-d'Or.
Globally optimal bilinear programming for computer vision applications (2008)

We present a practical algorithm that provably achieves the global optimum for a class of bilinear programs commonly arising in computer vision applications. Our approach relies on constructing tight convex relaxations of the objective function and minimizing it in a branch and bound framework. A key contribution of the paper is a novel, provably convergent branching strategy that allows us to solve large-scale problems by restricting the branching dimensions to just one set of variables constituting the bilinearity. Experiments with synthetic and real data validate our claims of optimality, speed and convergence. We contrast the optimality of our solutions with those obtained by a traditional singular value decomposition approach. Among several potential applications, we discuss two: exemplar-based face reconstruction and non-rigid structure from motion. In both cases, we compute the best bilinear fit that represents a shape, observed in a single image from an arbitrary viewpoint, as a combination of the elements of a basis.
Evaluation of (YBiCa)&lt;inf&gt;3&lt;/inf&gt;(FeSi)&lt;inf&gt;5&lt;/inf&gt;O&lt;inf&gt;12&lt;/inf&gt;epitaxial films for extended temperature range ion-implanted 4µm-period bubble devices (1982)

We report the results of wide temperature range material characterization and propagation studies on ion-implanted and annealed (Y <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1.9</inf> Bi <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.5</inf> Ca <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.6</inf> 0.6)(Fe <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4.4</inf> Si <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.6</inf> )O <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</inf> Effective uniaxial anisotropy field H <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</inf> decreases by less than a factor of 1.5 in going from -60C to +140 C compared with a factor of 8 for typical Lu-Sm garnets. Coercivity is less than 0.50e at -60C, and decreases monotonically to 0.14 Oe at 140C. Bubble propagation studies with 4μm-period ion-implanted propagation patterns and 40 Oe, 100 kHz drive field show propagation on the best type of tracks from -130 to 160C, with a bias field operating range greater than 30 Oe.
Abatacept Inhibition of T Cell Priming in Mice by Induction of a Unique Transcriptional Profile That Reduces Their Ability to Activate Antigen‐Presenting Cells (2015)

This study provides detailed insight into the mode of action of abatacept, demonstrating that its effectiveness is not due to the induction of T cell tolerance, but rather to a sustained inhibition of T cell activation that results in reduced functionality of APCs, with significant implications for its clinical application.
Localized Deposition of Coronene Molecules on Si(001)-2×1 Using a Scanning Tunneling Microscope Tip Source (2005)

The deposition of coronene molecules from scanning tunneling microscope (STM) tips onto a clean Si(001)-2x1 surface at 25 degrees C was investigated. The STM tips, contaminated with coronene, were found to deposit coronene molecules on the clean Si(001) surface, allowing patterns to be generated. Covalent Si-C chemical bonds, formed between the coronene molecules and the Si substrate, froze the flip-flop motion of the adjacent Si-Si dimers on the substrate. In most cases, the mode of coronene bonding to Si(001) is independent of whether deposition occurs from the gas phase or from the STM tip. Despite the covalent chemical bonds formed between the coronene molecule and the Si substrate, the STM tip can drag the coronene laterally on the Si substrate without inducing a chemical change in the molecule. Sharp spikes observed in the tunneling current during the coronene deposition reflect the abrupt decrease of the tip-substrate distance at the instant of transport of the molecule from tip to surface.
Enabling Adaptive Robot-Environment Interaction and Context-Aware Artificial Somatosensory Reflexes through Sensor-Embedded Fibers (2020)

Robotic control systems have conventionally lacked context-aware sensory capabilities and rapid sensorimotor reflexes, which has limited the capability of robotic platforms to adapt to new or different environments and tasks. While nerve-replicating sensors have been prototyped, low-latency reflex action is still not feasible with control systems that process sensory inputs subsequent to operational logic. We propose a robot-environment interaction protocol in which functionalized digital fibers with embedded sensors act as modular reflexogenic ‘garments’, outsourcing reflex computation to interchangeable sensory extremities and conferring artificial somatosensory reflexes to robots for effective adaptation to different tasks, target objects, environments, or use cases. By programming application-specific digital fibers with context-aware reflex thresholds, in-fiber microcontrollers can detect stimulus magnitude and generate digital interrupt signals, causing a predetermined reflex action to be activated from a central control system. As a proof of concept, digital fibers with embedded temperature sensors were used to model a “thermal glove” attachment and integrated with a 5-degree-of-freedom robotic manipulator. This prototype offers a testbed for the evaluation of reflexory function in a robot that contracts an extended manipulator arm in response to ambient or contact exposure to high temperatures, similar to the “hot stove” reflex arc of human arm motion. Even with relatively low-speed digital communications, rapid reflexory signal transmission can be achieved: while operating at I <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> C clock cycle speeds, sensory data collection and computation, threshold checking, and motion-triggering interrupt signal transmission can be completed up to 2 orders of magnitude faster than with conventional centralized computation of sensory inputs. With this protocol, separate sensorimotor reflexes can be added as needed with independent functionalized attachments, decreasing reflex latency and minimizing the computational load that main processors need to devote to computing sensory reflex actions. Modular sensory attachments decrease the need for complex centralized sensing systems or continuous reprogramming in preparation for separate tasks; this can reduce cost and time overhead incurred during equipment turnaround in operations leveraging robotic complements to human labor. In addition, these reflex fibers can be used to improve robotic spatial and sensory awareness and facilitate more efficient interactions with the robot's environment, improving balance and other tactile reflexes in humanoid / agile robots and enabling more effective bionic prosthetics and bioinspired robotic platforms.
LB1579. A single and a two-dose regimen of MVA-BN elicit similar memory responses to a boost vaccination two years after the initial regimen, indicating potential flexibility for a delayed second dose of MVA-BN in the ongoing monkeypox emergency (2022)

Abstract Background The ongoing monkeypox outbreak, a WHO-declared PHEIC, requires fast and broad rollout of MVA-BN vaccinations among risk groups. An initial single-dose strategy, followed by a delayed second dose beyond the approved 4-week interval, could help managing tight vaccine resources. Methods Bavarian Nordic has run a study in vaccinia-naïve participants, randomized to receive either 1 MVA-BN vaccination (N = 181) or 2 MVA-BN vaccinations 4 weeks apart (N = 183). Of note, this study also evaluated participants with prior smallpox vaccination, who received 1 MVA-BN boost (N = 200). Subsets of approximately 75 participants of the vaccinia-naïve subjects having received either 1 or 2 doses of the vaccine were administered an MVA-BN boost 2 years later. Neutralizing antibodies (nAb) were measured using Vaccinia PRNT. Results The 1xMVA-BN and 2xMVA-BN groups responded as expected to the primary regimen, with modest increases in nAb GMTs at Week 2 (5.1 and 4.8, respectively) that further increased at Week 4 (7.2 and 7.5). Two weeks after the second primary vaccination (at Week 6) (2xMVA-BN) nAb GMTs peaked (45.6) before stabilizing at Week 8 (34.0). In both the 1x and 2xMVA-BN groups, the nAb levels were near baseline 2 years after primary vaccination. After the MVA-BN boost at 2 years, both groups exhibited rapid anamnestic responses with nAb GMTs that peaked 2 weeks post-boost (80.7 and 125.3), at higher levels than those observed at any timepoint following primary vaccination, remaining elevated at 6 months post-boost (25.6 and 49.3). These anamnestic responses support the presence of durable immunological memory in both groups. No safety concerns were identified and the most common adverse event following a 2-year MVA-BN boost was injection site erythema in 82.2% of participants. Conclusion A single dose of MVA-BN elicits a durable memory immune response for at least 2 years. Similarly, high nAb responses following a boost dose among subjects in the initial 1xMVA-BN or 2xMVA-BN groups indicate that the approved 4-week interval of the two-dose regimen could optionally be extended up to at least 2 years. NCT00316524 and NCT00686582 Disclosures Heinz Weidenthaler, MD, Bavarian Nordic GmbH: Employee and received warrants Florian Lienert, PhD, Bavarian Nordic GmbH: employee Employee and received warrants Daniela Reichhardt, PhD, Bavarian Nordic A/S: employee Employee and received warrants Darja Schmidt, Dr, Bavarian Nordic GmbH: Employee and received warrants Günter Silbernagl, MSc, Bavarian Nordic: Employed|Bavarian Nordic GmbH: employee Employee and received warrants Paul Chaplin, PhD, Bavarian Nordic A/S: employee (CEO)|Bavarian Nordic A/S: Stocks/Bonds.
Geometric deformable colon model for polyp detection (2000)

Virtual Colonoscopy is a minimally invasive procedure to detect polyps in the colon using three dimensional tomographic imaging. An important step in analyzing the image data is accurate localization of the lumen surface. Polyps protruding into the colon lumen can then be identified by analyzing the surface either manually or using computer assisted techniques. We have developed a method for lumen segmentation based on a 3D geometric deformable model (GDM) to provide an improved representation of the lumen surface. The results show the GDM can remove the surface holes or tunnels that can be created with thresholding techniques and demonstrates the ability to accurately locate the lumen surface in high contrast air- tissue boundaries while preserving relatively lower contrast boundaries of the houstra and polyps.© (2000) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Current progress and trends in musculoskeletal research: Highlights of NSFC-CUHK academic symposium on bone and joint degeneration and regeneration (2022)

202401 bcvc
Listening in a Noisy Environment: Integration of active noise control in audio products (2016)

Have you ever faced a situation where you really wanted to enjoy your favorite music in a very noisy environment? To overcome this problem, you can either block the noise or increase the music level to mask the annoying sounds. This begets the question, "Is there a better solution?" In recent years, the technology industry has grown enormously, especially in the areas of smart, mobile, and wearable electronic products. Many companies are trying to gain consumers' attention by developing high-quality products equipped with advanced noise reduction. Among them, several companies have successfully used active noise control (ANC) techniques to cope with noise problems.
Poly(dimethylsiloxane)‐containing thermoplastic elastomer/gold–silver alloy nanocomposites for thermally/oxidatively stable and antimicrobial coating (2014)

Polymer materials with embedded silver (Ag) nanoparticle (NP) are of considerable interest owing to their enhanced antimicrobial activity and physical properties compared to host polymer. Antimicrobial and thermally/oxidatively stable coating not only enhances the durability of the coated material but also reduces the growth of bacteria/fungus and thus reduces the chance of infection. For this purpose, we have prepared polydimethylsiloxane‐containing predominantly poly(meth)acrylates‐based pentablock thermoplastic elastomer (TPE)/gold (Au)–Ag alloy nanocomposites (NCs) with antimicrobial activity and enhanced physical properties. In situ simultaneous reduction of appropriate amount of metal salts in the presence of block copolymer produced Au–Ag NPs of size 5–10 nm. Such embedded 5–10 nm sized particles (loading, 0.1–0.2 wt%) improved the mechanical property, thermal/oxidative stability, and antimicrobial activity of the NCs. The NC films also exhibited tunable surface wetting behavior and optical properties. The NC films showed low level of Ag leaching as confirmed by inductively coupled plasma spectrometer and UV–visible spectroscopy. Improved thermal/oxidative resistance of the TPE/Au–Ag alloy NCs enhanced antimicrobial activity, together with low level of leaching characteristic of the embedded NPs deemed suitable for further use of these NCs material for antimicrobial and oxidatively stable coating applications. POLYM. COMPOS., 36:2103–2112, 2015. © 2014 Society of Plastics Engineer
Multiple actions of φ-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins (2013)

We recently reported the isolation of a scorpion toxin named U1-liotoxin-Lw1a (U1-LITX-Lw1a) that adopts an unusual 3D fold termed the disulfide-directed hairpin (DDH) motif, which is the proposed evolutionary structural precursor of the three-disulfide-containing inhibitor cystine knot (ICK) motif found widely in animals and plants. Here we reveal that U1-LITX-Lw1a targets and activates the mammalian ryanodine receptor intracellular calcium release channel (RyR) with high (fM) potency and provides a functional link between DDH and ICK scorpion toxins. Moreover, U1-LITX-Lw1a, now described as ϕ-liotoxin-Lw1a (ϕ-LITX-Lw1a), has a similar mode of action on RyRs as scorpion calcines, although with significantly greater potency, inducing full channel openings at lower (fM) toxin concentrations whereas at higher pM concentrations increasing the frequency and duration of channel openings to a submaximal state. In addition, we show that the C-terminal residue of ϕ-LITX-Lw1a is crucial for the increase in full receptor openings but not for the increase in receptor subconductance opening, thereby supporting the two-binding-site hypothesis of scorpion toxins on RyRs. ϕ-LITX-Lw1a has potential both as a pharmacological tool and as a lead molecule for the treatment of human diseases that involve RyRs, such as malignant hyperthermia and polymorphic ventricular tachycardia.
Hypoxia-induced and A2A adenosine receptor-independent T-cell suppression is short lived and easily reversible (2013)

Tissue hypoxia plays a key role in establishing an immunosuppressive environment in vivo by, among other effects, increasing the level of extracellular adenosine, which then signals through A2A adenosine receptor (A2AR) to elicit its immunosuppressive effect. Although the important role of the adenosine--A2AR interaction in limiting inflammation has been established, the current study revisited this issue by asking whether hypoxia can also exert its T-cell inhibitory effects even without A2AR. A similar degree of hypoxia-triggered inhibition was observed in wild-type and A2AR-deficient T cells both in vitro and, after exposure of mice to a hypoxic atmosphere, in vivo. This A2AR-independent hypoxic T-cell suppression was qualitatively and mechanistically different from immunosuppression by A2AR stimulation. The A2AR-independent hypoxic immunosuppression strongly reduced T-cell proliferation, while IFN-γ-producing activity was more susceptible to the A2AR-dependent inhibition. In contrast to the sustained functional impairment after A2AR-mediated T-cell inhibition, the A2AR-independent inhibition under hypoxia was short lived, as evidenced by the quick recovery of IFN-γ-producing activity upon re-stimulation. These data support the view that T-cell inhibition by hypoxia can be mediated by multiple mechanisms and that both A2AR and key molecules in the A2AR-independent T-cell inhibition should be targeted to overcome the hypoxia-related immunosuppression in infected tissues and tumors.
Tunable, rare earth-doped solid state lasers (2023)

Laser apparatus comprising combinations of an excimer pump laser and a rare earth-doped solid matrix, utilizing the 5d-4f radiative transition in a rare earth ion to produce visible and ultra-violet laser radiation with high overall efficiency in selected cases and relatively long radiative lifetimes.
Milliwatt Power Blue InGaN/GaN Light-Emitting Diodes on Semipolar GaN Templates (2005)

Growth of semipolar Group-III nitrides based devices offers a means of reducing the deleterious effects of the polarization-induced electric fields present in the polar quantum wells. We report on the fabrication of blue InGaN/GaN multiple-quantum well light-emitting diodes (LEDs) on semipolar (10-1-1) and (10-1-3) oriented GaN templates. A maximum on-wafer continuous wave output power of 190 µW was measured at 20 mA for 300×300 µm 2 devices, and output power as high as 1.53 mW was measured at 250 mA. Drive-current independent electroluminescence peak at 439 nm was observed for the LEDs grown on both the planes. The current–voltage characteristics of these LEDs showed rectifying behavior with a forward voltage of 3–4 V at 20 mA.