gebhart/patrepeval huggingface dataset:
ChemInform Abstract: An Efficient Synthesis of Perfluoroalkyl Ketones Using Perfluoroalkyllithiums. (1988)

Abstract The esters (I) are coupled with perfluoroalkyl iodides (II) in the presence of methyllithium and LiBr to give the perfluoroalkyl ketones (IV) via the intermediates (III).
Implementation of Rx-side DSP-based fiber-longitudinal optical power profile monitoring for optical network tomography (2022)

We implemented a fiber-longitudinal optical power profile monitoring for an optical network tomography in the hardware accelerator. We experimentally confirmed the accuracy of positioning the excess loss was within ± 3km.
Host Identity Protocol Version 2 (HIPv2) (2015)

This document specifies the details of the Host Identity Protocol (HIP).HIP allows consenting hosts to securely establish and maintain shared IP-layer state, allowing separation of the identifier and locator roles of IP addresses, thereby enabling continuity of communications across IP address changes.HIP is based on a Diffie-Hellman key exchange, using public key identifiers from a new Host Identity namespace for mutual peer authentication.The protocol is designed to be resistant to denial-of-service (DoS) and man-in-themiddle (MitM) attacks.When used together with another suitable security protocol, such as the Encapsulating Security Payload (ESP), it provides integrity protection and optional encryption for upperlayer protocols, such as TCP and UDP.This document obsoletes RFC 5201 and addresses the concerns raised by the IESG, particularly that of crypto agility.It also incorporates lessons learned from the implementations of RFC 5201.
Superconducting sub-array module as T/R module for X-band active phased array antenna (2015)

We have developed a high-sensitivity superconducting sub-array module for an X-band active phased array antenna. This sub-array module can be assumed as a multichannel T/R module with 16 antenna elements. And the module also includes 16 transmitting (TX) channels and 16 receiving (RX) channels with high-Tc superconducting (HTS) filters. By means of this sub-array module, a high-sensitivity antenna can be easily available for wireless applications such as communication systems and radar systems. In this paper, we describe the newly developed X-band superconducting sub-array module that is applicable as a key component for an active phased array antenna. In particular, each Rx channel contains a cryogenic circuit that mainly consists of HTS filters and a low-noise amplifier (LNA) cooled at 77 K for low insertion loss and low internal noise. 16 cryogenic circuits are contained within a 100 mm×100 mm×36.5 mm vacuum chamber and cooled by a small cooler. By using HTS filters and cooling, noise temperature of the RX channels was reduced to less than 60 K and naturally the high-sensitivity X-band sub-array module was realized. Additionally, the features of the sub-array module, such as low amplitude deviation and good phase linearity, indicated that both TX channels and RX channels were appropriate for an active phased array antenna.
Self-Calibration of Traffic Surveillance Camera using Motion Tracking (2008)

A statistical and computer vision approach using tracked moving vehicle shapes for auto-calibrating traffic surveillance cameras is presented. Vanishing point of the traffic direction is picked up from linear regression of all tracked vehicle points. Preliminary straightening model is then built to help collect statistics of the typical vehicle class traveling in each particular scene. Analysis on this class eventually helps to compute the complete calibration parameters. Results obtained from the validation step against traditional methods in different traffic locations demonstrate its desirable accuracy with much more flexibility and reliability.
Synthesis of New Series of 1‐Aryl‐1,4‐dihydro‐4‐oxo‐6‐methyl Pyridazine‐3‐carboxylic Acid as Potential Antibacterial Agents. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Regional differences in precipitating factors of hospitalization for acute heart failure: insights from the REPORT‐HF registry (2022)

Data on global differences in precipitants for AHF highlight potential regional differences in targets for preventing hospitalization for AHF and identifying those at highest risk for early mortality.
Ultrasonic investigation of solute-solvent and solute-solute interactions in aqueous solutions of bases, nucleosides, and nucleotides. 2. pH-Dependent solute-solvent interactions (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUltrasonic investigation of solute-solvent and solute-solute interactions in aqueous solutions of bases, nucleosides, and nucleotides. 2. pH-Dependent solute-solvent interactionsV. A. Bukin, A. P. Sarvazyan, E. I. Dudchenko, and Paul HemmesCite this: J. Phys. Chem. 1980, 84, 7, 696–699Publication Date (Print):April 1, 1980Publication History Published online1 May 2002Published inissue 1 April 1980https://pubs.acs.org/doi/10.1021/j100444a003https://doi.org/10.1021/j100444a003research-articleACS PublicationsRequest reuse permissionsArticle Views75Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Bioprocess modelling for the design and optimization of lignocellulosic biomass fermentation (2016)

Lignocellulosic feedstocks, which are currently under-exploited, can be used for the production of biofuels, such as ethanol, and for biorefinery applications to produce a variety of value-added products. Although bioconversion of lignocellulose by microbial or yeast fermentation have been reported, efficient and economical lignocellulosic fermentation process is still a challenge due to multiple process parameters involved for bioprocess design, optimization and scale-up. Bioprocess modelling strategies have been proven effective for achieving high-production process* efficiency in yield, productivity or titer of desired product. Several types of bioprocess modelling for lignocellulosic application have been developed and successfully validated as a promising alternative for rapid design, optimization and scaling up of biomass-based process. This review aims to summarize the important development of bioprocess modelling for lignocellulosic bioprocess applications towards the success of biorefineries and bio-based economy. In particular, we discuss modelling relevant to lignocellulosic bioprocess including cell modelling based on kinetics, stoichiometry and integrative approaches and fermentation kinetic modelling for process performance assessment. An overview of these modelling approaches and their application for systematic design of efficient and economical lignocellulose-based bioprocesses are given.
Storage correction in cells of patients suffering from mucopolysaccharidoses types IIIA and VII after treatment with genistein and other isoflavones (2010)

Mucopolysaccharidoses are autosomal and recessive lysosomal storage disorders caused by the deficiency of a lysosomal enzyme involved in glycosaminoglycan catabolism. The Sanfilippo type A disease (MPS III A) results from sulfamidase deficiency, which leads to accumulation of heparan sulfate, whereas Sly disease (MPS VII) results from beta-glucuronidase deficiency, leading to accumulation of heparan, dermatan, and chondroitin sulfates. These syndromes are characterized by severe central nervous system degeneration, resulting in progressive mental retardation, and fatality occurs in severely affected children. To date, no effective treatment is available except for bone marrow transplantation in specific cases. Recently, the use of genistein, an isoflavone that inhibits glycosaminoglycans synthesis, has been tested as substrate reduction therapy for neuronopathic forms of these diseases.We tested five natural analogs to genistein in human fibroblasts from both Sanfilippo A and Sly patients. Four molecules were as efficient as genistein in decreasing glycosaminoglycan accumulation. Moreover, a combination of several isoflavones was more efficient than one single isoflavone, suggesting a synergistic effect. These preliminary data may offer new perspectives for treating Sly and Sanfilippo A diseases and could be relevant to other neurological forms of mucopolysaccharidoses.
Feedback control of pluripotency in embryonic stem cells: Signaling, transcription and epigenetics (2018)

Embryonic stem cells (ESCs) can proliferate and self-renew, maintaining their pluripotency status in vitro for a long period of time. Pluripotent states of ESCs in vitro are supported by a network of signaling, transcriptional and epigenetic regulatory interactions known as the pluripotency gene regulatory network (PGRN). Despite extensive investigation of the network, the exact order of regulatory links and many structural features of the network are still missing. Analysis of published data and literature reveals numerous PGRN components regulating each other in a mutual fashion, thus creating multiple regulatory feedback control circuits. Here we consider possible organizational features of PGRN and describe examples representing known feedback control loops in the context of mouse ESCs. We discuss how the feedback control interactions can contribute to learning behavior and dynamic responses of pluripotency gene network to changing environments.
Direct evidence of microscopic homogeneity in disordered solids (1982)

Nuclear spin diffusion can be utilized efficiently to gain information on the microscopic homogeneity in disordered solids. Two-dimensional NMR spectroscopy is employed for the measurement of the nuclear spin diffusion. The method is illustrated by comparing 2-dimensional 13C spin diffusion spectra of powder and melt-formed mixts. of adamantane and 2,2,3,3-tetramethylbutane. [on SciFinder (R)]
Assistance by Electrophiles in Photoinduced Alkylidyne–Carbonyl Coupling (1992)

A one-step synthesis of metal-coordinated ynols and ynol derivatives is possible by irradiation of the alkylidyne–carbonyl–tungsten complexes 1 and entrapment of the resulting ketenyl ligands with the electrophile E. Complexes 2 are obtained in good yields. R = Me, Ph; E = H, C(O)CMe3, Si(CMe3)2Ph.
Detecting cis -regulatory binding sites for cooperatively binding proteins (2008)

Several methods are available to predict cis-regulatory modules in DNA based on position weight matrices. However, the performance of these methods generally depends on a number of additional parameters that cannot be derived from sequences and are difficult to estimate because they have no physical meaning. As the best way to detect cis-regulatory modules is the way in which the proteins recognize them, we developed a new scoring method that utilizes the underlying physical binding model. This method requires no additional parameter to account for multiple binding sites; and the only necessary parameters to model homotypic cooperative interactions are the distances between adjacent protein binding sites in basepairs, and the corresponding cooperative binding constants. The heterotypic cooperative binding model requires one more parameter per cooperatively binding protein, which is the concentration multiplied by the partition function of this protein. In a case study on the bacterial ferric uptake regulator, we show that our scoring method for homotypic cooperatively binding proteins significantly outperforms other PWM-based methods where biophysical cooperativity is not taken into account.
Register file port requirements of transport triggered architectures (1994)

Exploitation of large amounts of instruction level parallelism requires a large amount of connectivity between the shared register file and the function units; this connectivity is expensive and increases the cycle time. This paper shows that the new class of transport triggered architectures requires fewer ports on the shared register file than traditional operation triggered architectures. This is achieved by programming data-transports instead of operations. Experiments with our extended basic block scheduler have shown that the reduction of the required number of register file ports is substantial. The average requirement for scalar applications is 0.50 read and 0.35 write ports per operation instead of 2 read and 1 write ports. Due to this reduction it is possible to execute 2 operations per cycle with a two-ported register file and 3.6 operations per cycle with a six-ported register file.
A preliminary study on the effects of roll dynamics in predictive vehicle stability control (2008)

A model predictive control (MPC) -based approach is presented for autonomous path following via active front steering (AFS). We start from the nonlinear MPC (NMPC) problem formulations in [2] and [4], where a simple bicycle model is used, and reformulate the same problem by using a more complex vehicle model including roll dynamics. We present and discuss simulation results of a vehicle autonomously performing high speed double lane change maneuvers, where load transfer effects due to roll dynamics become relevant. The results demonstrate that the inclusion of the roll dynamics in the prediction model of the MPC controller significantly improves the vehicle behavior at high speed on high friction surfaces, when significant lateral load transfers occur.
Abstract 2819: Suppression of NKG2A mediated inhibition in ex vivo expanded natural killer cells increases their cytotoxicity (2022)

Abstract In this study we propose to circumvent HLA-E/NKG2A mediated Natural Killer (NK) cell inhibition by suppression of NKG2A, to enhance cytotoxicity of ex vivo expanded NK cells. One mechanism employed by tumor cells to evade immunosurveillance is through induction of the surface expression of unconventional HLA ligands that agonize inhibitory receptors on immune cells. Specifically on some tumors, HLA-E is either expressed or its expression is known to be induced by IFNγ and is indicative of resistance to immunotherapy. HLA-E agonizes the CD94/NKG2A inhibitory complex on NK cells and some T cells to lessen their cytotoxicity, potentially decreasing the efficacy of cellular therapy with these immune cells. The CD94/NKG2A inhibitory complex is in balance with CD94/NKG2C stimulatory complex. HLA-E binds both of these complexes and the cytolytic activity of NK cells is influenced by the relative ratios of CD94 complexed to NKG2A or NKG2C. Thus, altering the ratio to increase NKG2C will increase NK cell cytotoxicity. In this study we show that NK cells ex vivo expanded with PM21-particle technology are highly cytotoxic and have elevated expression of NKG2A. These expanded NK cells also secrete high levels of IFNγ, inducing expression of HLA-E in tumor cells. To increase the cytotoxic potential of these ex vivo expanded NK cells, the potential to form CD94/NKG2A inhibitory complex was suppressed by either antibody blockade of NKG2A or deletion of the NKG2A gene by CRISPR/Cas9 editing. Cytotoxicity of NK cells against a lung cancer cell line stably expressing HLA-E were determined by kinetic live-cell imaging. Multiple NK cell:target (NK:T) ratios were used to show an increase in cytotoxicity over control NK cell conditions (alone or with isotype control) in the presence of NKG2A blocking antibodies with 39% increase observed at 1:10 NK:T ratio at 96h with anti-NKG2A and 56% increase with NKG2A knockout NK cells. These data suggest that blockade of CD94/NKG2A complex can improve cytotoxic activity of ex vivo expanded NK cells and could provide a promising effector population with the potential for enhanced therapeutic efficacy. Citation Format: Tayler J. Croom-Perez, Liza D. Robles-Carrillo, Thomas A. Dieffenthaller, Alicja J. Copik. Suppression of NKG2A mediated inhibition in ex vivo expanded natural killer cells increases their cytotoxicity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2819.
Elucidating the Mass Transport Properties of Additively Manufactured Electrodes Using Spatially Resolved Simulation (2020)

Flow through electrodes are the core, active component in a number of electrochemical systems including fuel cells and flow batteries. Controlling fluid flow and mass transport is a core engineering challenge in these systems and has a dramatic impact on cell power, utilization, and efficiency. Most advanced electrode materials are composed of microscale, disordered porous media. The length scales of these materials allow for very large surface area but at the cost of low flow speeds, low surface mass transfer rates, high pressure drops, and added complexity and cost from the need to use external flow distribution systems like flowfields. The multiscale control over electrode architecture enabled by using additively manufactured electrodes could provide a potential resolution to these trade-offs. To elucidate the mass transport of these electrodes, we use resolved, continuum computation to analyze the fluid flow and species transport in direct ink-write printed, carbon aerogel electrodes. We determine the mass transfer correlations (Sh ~ Pe a ) across two different lattice aerogel geometries and validate these results against the experimentally manufactured and tested flow-through electrodes operated at limiting current. In contrast to conventional electrodes, the mesoscopic length scales in our electrodes lead to finite Reynolds numbers and we find an increase in the mass correlation exponent (a) as inertial effects become important. We analyze the local mass transfer coefficients in the electrode and correlate regions of enhanced mass transfer with secondary flows in the electrode. Our work provides a promising new pathway to increased mass transfer rates in flow-through electrodes. LLNL-ABS- 810719 This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.
Synthesis of Pd-coated FeCo@Fe/C core–shell nanoparticles: microwave-induced ‘top-down’ nanostructuring and decoration (2013)

We report a novel microwave-induced fast and efficient synthesis of sub-10 nm sized palladium-decorated FeCo@Fe core-shell nanoparticles (ca. 3-7 nm) from a large-sized FeCo@Fe (0.21-1.5 μm) precursor, suggesting 'top-down' nanosizing. The high electrochemical surface area, tolerance to methanol during oxygen reduction reaction, and the excellent stability of FeCo@Fe@Pd in alkaline electrolytes indicate that this nanomaterial may find future applications in Pd-based catalysis and/or alkaline fuel cells.
ChemInform Abstract: Direct Azidation of Adamantane and Norbornane by Stable Azidoiodinanes. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Determination of Follicle Regulatory Protein Levels in Urine During the Normal Menstrual Cycle Using an Enzyme-Linked Immunosorbant Assay* (1988)

A protein from follicular fluid [referred to as follicle regulatory protein (FRP)] which inhibits aromatase activity in granulosa cells was recently isolated and partially characterized. The purified FRP was used to produce a monoclonal antibody which was used to develop an enzyme-linked immunosorbant assay suitable for quantitation of FRP in urine. Twelve normal premenopausal women underwent daily collection of blood and first morning urine samples, beginning on the 1st day of menses, as well as daily ultrasonographic evaluation of follicular diameter, beginning on the 10th day of the menstrual cycle, until the onset of the next menses. Serum estradiol, progesterone, LH, and FSH levels were determined by RIA. Urinary FRP levels increased in the midfollicular phase, reached their zenith in the midluteal phase [mean, 0.38 +/- 0.03 (+/- SE) immunoreactive units; 1 immunoreactive unit = approximately 1 ng FRP/mL.mg creatinine], and then declined to reach their nadir (not detectable) during the early follicular phase. Immunohistochemical evaluation of ovarian tissue demonstrated that anti-FRP localized to mural granulosa cells in viable follicles, to all follicular epithelial cells in atretic follicles, and to the large cells of the corpus luteum. These findings indicate that immunoreactive FRP levels in urine change during the menstrual cycle and suggest a relationship among FRP, follicular maturation, and corpus luteum formation.
Favorable effects of glycolate conjugation on the biodistribution of humanized antiTac Fab fragment. (1999)

Glyco-Fab is a promising agent because of its lower renal accumulation, higher tumor uptake and higher tumor-to-normal tissue ratio.
Differential Protein Assembly on Micropatterned Surfaces with Tailored Molecular and Surface Multivalency (2006)

Addressable protein arrays. The binding affinity of histidine-tagged proteins towards metal-chelating surfaces was tailored by combining molecular and surface multivalency. Protein immobilization onto piezo-dispensed density microarrays of mono- and bivalent chelating SAMs was monitored by imaging surface plasmon resonance (I–II). Selective protein elution from specific array elements (III) enabled selective targeting and mixing of different proteins (IV).
Ivacaftor-induced sweat chloride reductions correlate with increases in airway surface liquid pH in cystic fibrosis (2018)

Vertex Inc., the NIH (P30DK089507, 1K08HL135433, HL091842, HL136813, K24HL102246), the Cystic Fibrosis Foundation (SINGH17A0 and SINGH15R0), and the Burroughs Wellcome Fund.
Telerobotic remote handling of protein crystals (2002)

A combined university/industry team has developed a prototype system for handling protein crystals aboard the space station. This system uses a miniature direct drive robot, CCD television cameras, and a client-server computing system using Internet protocols to support the capture of protein crystals from aqueous growth solutions. The system was demonstrated between Huntsville AL. and Seattle WA. An operator in Huntsville controlled the mini robot by invoking predefined relative and absolute macro files. The operators observed results using video images sent through the Internet link using Cu-SeeMe video conferencing software. In 3 of 4 trials, the operators successfully captured 0.5 mm simulated protein crystals into a glass capillary. The system is a promising start for the development of a space-station based remote protein crystal analysis facility.