gebhart/patrepeval huggingface dataset:
Initial results from ASSURE (E2805): Adjuvant sorafenib or sunitinib for unfavorable renal carcinoma, an ECOG-ACRIN-led, NCTN phase III trial. (2015)

403 Background: Patients (pts) with locally advanced renal cell carcinoma (RCC) are not uniformly cured by resection. The pursuit of tolerable and effective adjuvant therapies led to this investigation of two oral agents that are widely effective in the metastatic setting. Methods: 1,943 pts with completely resected RCC (pT1b high grade to pT4 any grade N any) were stratified on risk (intermediate-high or very high), clear/non-clear histology, ECOG PS, and resection approach, and randomized equally to sunitinib daily for 4 of 6 wk cycle, sorafenib daily, or placebo, then treated for up to 1 year. The primary endpoint was disease-free survival (DFS). The study was designed to detect a 25% reduction in the hazard rate, corresponding to an improvement from 5.8 to 7.7 years median DFS. After accrual of 1322 pts, the starting dose was reduced and then individually titrated to mitigate the effect of pt discontinuation from treatment intolerance. Results: At an interim analysis conducted with 62% information, although no efficacy or futility boundaries were crossed, the Data Safety Monitoring Committee recommended release of results. Using a stratified log-rank test, there were no significant differences in DFS or overall survival between either of the experimental arms and placebo. The redesign reduced the discontinuation rate on the experimental arms from about 26% in pts starting at full dose to about 14% in pts starting at reduced dose. Most common grade ≥3 adverse events were hypertension (16%/16%/4%), hand-foot reaction (15%/33%/1%), Rash (2%/15%/&lt;1%), and fatigue (17%/7%/3%) on sunitinib, sorafenib and placebo, respectively. (See Table.) Conclusions: In pts with locally advanced, resected RCC, adjuvant treatment with sorafenib or sunitinib should not be pursued. Dose titration reduced the treatment discontinuation rate; this finding may have relevance in other settings. Clinical trial information: NCT00326898. [Table: see text]
Effects of Alloying Elements of the Creep Resistance of Thixomolded Mg‐Al‐Ca‐X (X=Si, Zn, Mm, Ba, Sr) Alloys (2000)

In order to develop heat-resistant Mg alloys for the thixomolding process, we have developed Mg-Al-Ca alloys and reported a good creep resistance of the alloys. In this work, we aimed at further improving the creep resistance by the addition of other alloying elements. The paper reports creep resistance of Mg-Al-Ca-X (X = Si, Zn, Mm, Ba, Sr) alloys and discuss the effects of each alloying element.
Cover Picture: Shear‐Responsive Platelet Mimetics for Targeted Drug Delivery (Isr. J. Chem. 9‐10/2013) (2013)

The cover shows an illustration of shear-responsive platelet mimetics (large blue aggregates) breaking apart and localizing drug-carrying nanoparticles (blue dots) at regions of vascular narrowing that produce high shear stress. Read more in the Review by Korin et al. on page 610.
The accuracy of reverse genetics systems for SARS‐CoV‐2: Circular polymerase extension reaction versus bacterial artificial chromosome (2023)

We found that the accuracy of the CPER method is lower than that of the BAC method. Our findings suggest care should be used when employing the CPER method.
Omc for Poorly Conductive Products in Rechargeable Sodium-Air Batteries (2015)

Development of renewable energy resources requires high-efficiency energy conversion and large-scale, low-cost, high-density energy storage devices. The energy density of traditional Li ion batteries is inadequate to meet the increased requirements, especially for electric or hybrid electric vehicles. Metal air batteries 1-5 have attracted a great deal of attention mainly because of the extremely high energy density of the metal-air battery system, which is close to the energy density of fossil fuels. One advantage of Na–air batteries over Li-ion or Li–air batteries is its low material cost and its natural abundance, as sodium is 30 times cheaper than lithium. Moreover, the energy density of a Na–air battery is similar to the maximum practical energy density of a Li–air battery (1600 Wh/kg). 6 As a common challenge to be addressed for all air-based battery technologies, excessive discharge products can accumulate on the cathode surface; most of these have very low electrical conductivity, and thus tend to inactivate surface reaction sites and block oxygen diffusion channels. Hence, the over-accumulation of discharge products can lead to the increase in polarization during charging of the Na–air battery and eventual termination of the oxygen evolution reaction. 7 To reduce the accumulation of discharge products for decreased charge potential and improved cycling performance, morphological properties of the cathode (e.g. surface area, pore volume, and pore size) need to be tailored while employing different catalysts. However, to the best of our knowledge, there have been no reports of research efforts to confine the size or arrangement of discharge products in the vicinity of the cathode to decrease the charge potential and improve the cycling behavior of Na–air batteries. In the present work, OMC having 2.7 nm size pore (OMC-2.7) was employed as a cathode material to control the formation and subsequent decomposition of discharge products, and thus to reduce polarization and improve cycling behavior. References [1] Abraham K. M., Jiang Z., J. Electrochem. Soc. 1996, 143, 1−5. [2] A. Inoishi, S. Ida, S. Uratani, T. Okano, T. Ishihara, Phys. Chem. Chem. Phys. 2012, 14, 12818–12822. [3] G. Cohn, Y. Ein-Eli, J. Power Sources 2010, 195, 4963–4970. [4] J.-S. Lee, S.-T. Kim, R. Cao, N.-S. Choi, M. Liu, K. T. Lee, J. Cho, Adv. Energy Mater. 2011, 1, 34–50. [5] S. Yang, H. Knickle, J. Power Sources 2002, 112, 162–173. [6] Peled E., Golodnitsky D., Mazor H., Goor M., Avshalomov S., J. Power Sources 2011, 196, 6835-6840. [7] Pascal Hartmann, Conrad L. Bender, Joachim Sann, Anna Katharina Du¨rr, Martin Jansen, Ju¨rgen Janek, Philipp Adelhelm, Phys. Chem. Chem. Phys. 2013, 15, 11661-11672.
Reduced C9orf72 expression exacerbates polyGR toxicity in patient iPSC-derived motor neurons and a Type I protein arginine methyltransferase inhibitor reduces that toxicity (2023)

This study explores the interplay of loss-of-function and gain-of-function toxicity in C9orf72 ALS. It also implicates type I PRMT inhibitors as a possible modulator of polyGR toxicity.
New Insight in Noninvasive Rejuvenation: The Role of a Rhodamine-Intense Pulsed Light System (2019)

<b><i>Background:</i></b> Rhodamine-intense pulsed light (r-IPL) is a noncoherent, noncollimated, polychromatic light energy optimized for a double-peak wavelength emission, ranging between 550-680 and 850-1200 nm. Traditional IPL works within visible and infrared spectra, targeting hemoglobin and melanin, are effective to treat rosacea and pigmentary disorders. r-IPL, a new technology in dermatology, emits high-intensity light with a wavelength peak similar to the one of the pulsed dye lasers, showing a good safety and efficacy profile in nonablative photorejuvenation. <b><i>Objective:</i></b> Assess efficacy and safety of r-IPL on photodamaged facial skin showing hyperpigmentation, telangiectasias, fine lines, and textural changes. <b><i>Methods:</i></b> Five sessions of r-IPL treatment (fluence ranged between 13.5 and 14 J/cm<sup>2</sup>) have been performed on one 75-year-old lady affected by facial photodamaged skin. Efficacy of treatment was evaluated using the Fitzpatrick Elastosis and Wrinkles Scale (FEWS) and the Global Aesthetic Improvement (GAI) Scale assessed by an investigator, compared with baseline. Treatment safety and tolerance were also evaluated using the Visual Analog Scale (VAS). <b><i>Results:</i></b> Photographic and multispectral evaluation demonstrated relevant improvement (vascular, pigment, and texture) of photodamaged facial skin. One month after the last treatment, significant improvement in facial wrinkle and texture was noted. FEWS scores decreased significantly from 7 to 2. According to the GAI scale, the patient had an improvement in skin texture. Immediate response included mild-to-moderate erythema and only trace-mild edema in the treatment area. Pain during the treatment was minimal with a mean VAS pain score of 3/10. No other adverse events were reported. No post-treatment downtime was recorded. <b><i>Conclusions:</i></b> r-IPL may represent a valid therapeutic approach in noninvasive photorejuvenation.
Biochemical and biophysical characterization of NarE from Neisseria meningitidis (2008)

BIOCHEMICAL AND BIOPHYSICAL CHARACTERIZATION OF NarE FROM Neisseria meningitidis\nNarE (Neisseria meningitidis ADP-ribosylating enzyme) is an ADP-ribosylating putative toxin identified in the virulent strain MC58 of N. meningitidis serogroup B by computational approach. \nMethods. NarE was expressed in E. coli as a C-terminal His-tag fusion protein and purified on nickel columns in anaerobic conditions (rNarE). \nResults. Enzymatic assays have shown that rNarE links the ADP-ribose unit from β-nicotinamide adenine dinucleotide (NAD+) to small guanidine compounds like agmatine at a rate of 6.7±0.87 nmoles hr-1 with the simultaneous release of nicotinamide (Nam). We have noticed that addition of Fe3+ in the mixtures of enzymatic assays enhanced three fold the incorporation of radioactive ADP-ribose, while the presence of o-phenanthroline, a specific iron chelator, drastically reduced the enzymatic activity. These results together with the presence of four Cys spaced as residues of iron-sulfur-cluster motif, prompted us to confirm the presence of this structure using the EPR technique, a method that evidences the presence of paramagnetic ions and identifies the type of coordination in which they are involved. EPR experiments carried out combining rNarE with FeCl3 evidenced the presence of an iron center sourrended by four Cys residues. Further, EPR signal obtained at g=4.3 indicates the presence of a single Fe3+ atom in a distorted sulfur ligands field. In order to confirm the presence of the Fe-S cluster Cys mutated forms of rNarE have already obtained and used for enzymatic assays.\nConclusion. Our experiments confirmed, as the rNarE enzymatic activity is strictly dependent by the presence of iron coordinated with the four cysteines.
Non-spherical particle size estimation using supervised machine learning (2020)

The inverse scattering problem of non-spherical particle size estimation is solved using a series of supervised machine learning models trained on a library of light scattering data. By establishing a large library with spheres and spheroids as fundamental shapes and through optimization of model hyperparameters, the trained models are able to accurately estimate a precise equivalent volume sphere radius of particles from an external database and simulations, with root mean square errors of 2.6% and 1.9% for the external and simulated particles, respectively. It was found that classification via a <i>k</i>-nearest neighbor model and refinement via a trained ensemble regression model performed best for equivalent volume measurements.
Adaptation to pollutants through modifications of sensitivities and life-history traits: a case study based on nine field Gammarus populations (2013)

The question of evolutionary processes in ecotoxicology becomes substantial in order to propose relevant ecological risk assessment. Actually, it is well admitted that pollutants can be strong selective agents which can induced adaptation in exposed populations. Our study analyses two possible ways of adaptation: first, the evolution of resistance and second, the evolution of life-history patterns. This second point is rarely tackled in ecotoxicological issues, contrary to other fields of ecology dealing with stress adaptation. \nTo answer these questions we adopted a retrospective approach based on the comparison of sensitivities and traits of exposed and unexposed field populations. To provide representative results, the choice has been made to work on an ecologically and ecotoxicologically relevant species, the freshwater amphipod, Gammarus fossarum. Particular attention was also paid to the design of the study through the sampling effort with the selection of nine field populations spread out at a regional scale. \nThe exposition of organisms from these populations to cadmium, and the measure of their life-history traits in the field and in common garden in the lab, show that organisms are not only able to respond to pollutants by increased tolerance, but also by life-history adaptation. Nevertheless, our results also demonstrate that adaptation is not automatic and seems to depend on contamination strength. In addition, these phenomenon are probably not out of unexpected outcomes since they can induced fitness costs, and changes in population dynamics can affect higher ecological scales.
Accelerated Compressed Sensing Based CT Image Reconstruction (2021)

In X-ray computed tomography (CT) an important objective is to reduce the radiation dose without significantly degrading the image quality. Compressed sensing (CS) enables the radiation dose to be reduced by producing diagnostic images from a limited number of projections. However, conventional CS-based algorithms are computationally intensive and time-consuming. We propose a new algorithm that accelerates the CS-based reconstruction by using a fast pseudopolar Fourier based Radon transform and rebinning the diverging fan beams to parallel beams. The reconstruction process is analyzed using a maximum-a-posterior approach, which is transformed into a weighted CS problem. The weights involved in the proposed model are calculated based on the statistical characteristics of the reconstruction process, which is formulated in terms of the measurement noise and rebinning interpolation error .Therefore, the proposed method not only accelerates the reconstruction, but also removes the rebinning and interpolation errors. Simulation results are shown for phantoms and a patient. For example, a 512 × 512 Shepp-Logan phantom when reconstructed from 128 rebinned projections using a conventional CS method had 10% error, whereas with the proposed method the reconstruction error was less than 1%.Moreover, computation times of less than 30 sec were obtained using a standard desktop computer without numerical optimization.
Le cartilage articulaire peut-il se régénérer ? (1ère partie) (1998)

peer reviewed
A 10-Bit current-steering FinFET D/A converter (2008)

In this paper we present the first complex mixed-signal FinFET circuit (>1500 devices). Design and implementation aspects as well as measurement results of a 10-bit current- steering D/A converter are shown. The achieved performance proves the ability of recent FinEET technology to realize competitive mixed-signal circuits with large device count and wide range of device dimensions. Moreover the promising matching and analog behavior of FinFETs enables reduced circuit area compared to planar designs.
A constant-transfer-function widely-tunable VHF modular field-programmable filter array (FPFA) with IIP3 of 38–52 dBm (2016)

A 3D modular field-programmable filter array (FPFA) with high third-order input intercept point (IIP3) capable of delivering a constant transfer function through an octave tuning range is presented in this paper. An RF design methodology to fulfill the concept of an FPFA in a modular configuration is reported for the first time. The theoretical concept and its associated practical RF design considerations for IIP3 improvement in an octave tuning range are discussed. This modular FPFA allows for hardware extension at will, addressing the needs of next generation RF front-ends with multi-standard operability. An experimental 3D four-resonator FPFA has been designed, built and measured for proof-of-concept demonstration purposes. It functionalizes transfer functions with variable: i) order, ii) center frequency and iii) bandwidth. Furthermore, within an octave tuning range (98-194 MHz), the IIP3 was measured between 38-52 dBm.
ChemInform Abstract: Actinide Polyoxometalates: Incorporation of Uranyl—Peroxo in U‐Shaped 36‐Tungsto‐8‐phosphate. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Consumo de tabaco y alcohol en adolescentes de 10 a 14 años de la ciudad de San Felipe, Chile: prevalencia y factores asociados (2016)

Tobacco and alcohol use is highly prevalent in adolescents aged 10-14 years. There were common risk factors for smoking and alcohol use such as age and having behavioral problems, while other factors were more specific such as mothers smoking, or parental alcohol use.
Nanofluidic Trapping of Faceted Colloidal Nanocrystals for Parallel Single-Particle Catalysis (2022)

Catalyst activity can depend distinctly on nanoparticle size and shape. Therefore, understanding the structure sensitivity of catalytic reactions is of fundamental and technical importance. Experiments with single-particle resolution, where ensemble-averaging is eliminated, are required to study it. Here, we implement the selective trapping of individual spherical, cubic, and octahedral colloidal Au nanocrystals in 100 parallel nanofluidic channels to determine their activity for fluorescein reduction by sodium borohydride using fluorescence microscopy. As the main result, we identify distinct structure sensitivity of the rate-limiting borohydride oxidation step originating from different edge site abundance on the three particle types, as confirmed by first-principles calculations. This advertises nanofluidic reactors for the study of structure-function correlations in catalysis and identifies nanoparticle shape as a key factor in borohydride-mediated catalytic reactions.
Supplementary Figure 1 from Mitochondrial/Cell-Surface Protein p32/gC1qR as a Molecular Target in Tumor Cells and Tumor Stroma (2023)

Supplementary Figure 1 from Mitochondrial/Cell-Surface Protein p32/gC1qR as a Molecular Target in Tumor Cells and Tumor Stroma
Improving the letter of recommendation (2010)

The selection of applicants to otolaryngology training programs is a challenging task. Applicants and their evaluators rely on objective and subjective data to facilitate the selection process. Unfortunately, data are often less helpful than either side assumes, suffering from poor validity and reliability in predicting future performance. The traditional resume-based letter of recommendation bears some responsibility in this. It is often a lengthy reiteration of already available objective data and contains nonstandardized, superlative evaluations of personal attributes. As a result, many letters are similar, describing "excellent" candidates who have done well on previous examinations and clerkships. Research has indicated improved reliability and satisfaction as well as decreased time expenditure using standardized letters of recommendation. These letters demonstrate how basic, easy-to-implement improvements can create letters that provide accurate information, separate applicants, and improve the selection process. Consideration should be given to adopting these improvements at the program director and/or educational committee level.
Research Note: Scalding Conditions Can Improve the Appearance of Broilers with Scabby-Hip Syndrome (1990)

On processed broiler carcasses, scabs and scratches have become a common cause of downgrading and trimming for commercial processors. Currently, processors may have little or no recourse in reducing the incidence of this problem in the field, but the present report indicates that scalding conditions can improve the appearance of broiler carcasses with scabby hip lesions. Soft-scalding (53.3 C, 120 s) resulted in fewer (P<.01) scab-containing scratches than subscalding at 60.6 C for either 45 or 60 s. By contrast, soft-scalding resulted in more (P<.01) scratch-related skin discolorations man either of the subscald treatments.
Feline immunodeficiency virus is a lentivirus associated with an AIDS-like disease in cats (1989)

Sparger, E. Elizabeth; Luciw, Paul A.; Elder, John H.; Yamamoto, Janet K.; Lowenstine, Linda J.; Pedersen, Niels C. Author Information
<title>PtSi infrared focal plane arrays and thermovision systems based on them</title> (1999)

This paper describes focal plane arrays and thermovision systems for the middle infrared spectral region. The focal plane arrays are monolithic platinum silicide Schottky barrier infrared charge coupled devices. They have been designed for infrared imaging application in the 1 divided by 5.5 micrometers wavelength range. The array advantages include the high thermal and spatial resolution, the low noise readout, and a high uniformity of the sensitivity. Two types of infrared focal plane arrays are being discussed and experimental characteristics of the arrays are presented. High quality thermal images of real time can be produced by using this focal plane arrays. Different design configurations of FPA-modules for Sterling cooler are being considered and the features of the information processing in thermovision systems are presented. The thermovision system based on designed arrays with the lens f/1.1, 90 mm provides a temperature resolution: NETD equals 0.07 K.
Additional file 7: Table S16. of Comprehensive promoter level expression quantitative trait loci analysis of the human frontal lobe (2016)

All identified sentinel cis eQTLs. List of possible causal variant cis eQTL based on location and lowest p value including CAGE-cluster and SNPs chromosomal positions; gene ID; biotype class according to GENCODE; FDR values and RegulomeDB scores. (XLSX 419 kb)
Aetiology, Diagnosis and Treatment of Hydrops Foetalis (2005)

Hydrops foetalis is defined as a state of excessive fluid accumulation in the extravascular compartment of the foetus, leading to widespread soft tissue oedema and / or accumulation of fluid in the foetal body cavities. The prognosis of hydrops foetalis is highly dependent on the underlying pathology and early diagnosis is essential to identify treatable cases. The classification of immune and non-immune hydrops foetalis describes the difference between Rhesus haemolytic disease of the newborn and other aetiologies leading to hydrops foetalis. With improved diagnosis and treatment of Rhesus iso-immunisation, non-immune factors have become more frequent. Distinction between anaemic and non-anaemic hydrops foetalis provides a far more useful differentiation between aetiologies. This approach is used to discuss differential diagnosis, work-up and therapeutic options in hydrops foetalis. A structured multidisciplinary work-up will facilitate early diagnosis and assist in making treatment decisions. Keywords: hydrops foetalis, classification, aetiology, diagnosis, work-up
Distributed Inertial Best-Response Dynamics (2018)

The note considers the problem of computing pure Nash equilibrium (NE) strategies in distributed (i.e., network-based) settings. The paper studies a class of inertial best-response dynamics based on the fictitious play (FP) algorithm. It is shown that inertial best-response dynamics are robust to informational limitations common in distributed settings. Fully distributed variants of FP with inertia and joint strategy FP (JSFP) with inertia are developed and convergence is proven to the set of pure NE. The distributed algorithms developed in the paper rely on consensus methods. Results are validated using numerical simulations.