gebhart/patrepeval huggingface dataset:
The design of multidimensional FIR perfect reconstruction filter banks for arbitrary sampling lattices (2003)

Summary form only given. The design of multidimensional perfect reconstruction filter banks (PRFBs) for arbitrary sampling lattices has been addressed. Necessary and sufficient conditions have been formulated for perfect reconstruction within this general context, and the design of multidimensional finite-impulse-response (FIR) PRFBs has been shown using a method that optimizes directly over the impulse response coefficients of the analysis and synthesis filters, expressing the perfect reconstruction condition as a set of equality constraints involving the impulse response coefficients. Symmetries among various filters in the filter bank or within a single filter not only serve to reduce the number of variables in the design problem, but also manifest themselves in the form of automatically satisfied constraints and redundancies among the constraints. In both cases, the total number of constraints in the design problem is reduced. The multidimensional filter banks share some desirable properties with their one-dimensional counterparts: the analysis and synthesis filters are equal complexity FIR filters, and it is possible to design systems with any number of channels.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The Structural Basis of Gas-Responsive Transcription by the Human Nuclear Hormone Receptor REV-ERBβ (2009)

Heme is a ligand for the human nuclear receptors (NR) REV-ERBalpha and REV-ERBbeta, which are transcriptional repressors that play important roles in circadian rhythm, lipid and glucose metabolism, and diseases such as diabetes, atherosclerosis, inflammation, and cancer. Here we show that transcription repression mediated by heme-bound REV-ERBs is reversed by the addition of nitric oxide (NO), and that the heme and NO effects are mediated by the C-terminal ligand-binding domain (LBD). A 1.9 A crystal structure of the REV-ERBbeta LBD, in complex with the oxidized Fe(III) form of heme, shows that heme binds in a prototypical NR ligand-binding pocket, where the heme iron is coordinately bound by histidine 568 and cysteine 384. Under reducing conditions, spectroscopic studies of the heme-REV-ERBbeta complex reveal that the Fe(II) form of the LBD transitions between penta-coordinated and hexa-coordinated structural states, neither of which possess the Cys384 bond observed in the oxidized state. In addition, the Fe(II) LBD is also able to bind either NO or CO, revealing a total of at least six structural states of the protein. The binding of known co-repressors is shown to be highly dependent upon these various liganded states. REV-ERBs are thus highly dynamic receptors that are responsive not only to heme, but also to redox and gas. Taken together, these findings suggest new mechanisms for the systemic coordination of molecular clocks and metabolism. They also raise the possibility for gas-based therapies for the many disorders associated with REV-ERB biological functions.
Structural Studies of RSHgII Complexes Containing (-Hg-SR-)n Rings and Chains (1979)

Crystals of acetato(methanethiolato)-?-picolinemercury(11), MeSHgO2CMe,C6H7N (I), are monoclinic, P21/a, a 16.617(9), b 7.271(3), c 20.476(2) Å ß 113.31(5)º, Z 8. The structure resembles that of its pyridine analogue, being based on a polymeric (-Hg-SMe-)n chain with acetate and picoline groups coordinated at each mercury; a similar structure is found for EtSHgO2CMe,C5H5N (2), monoclinic, P21/c, a 9.344(2), b 17.917(9), c 7.179(2) Å,ß 106.24(3)º, Z 4. The structure of tetrachlorotetra(2-methylpropane-2-thiolato)di(?-picoline) tetramercury(11), (BUtS)4Cl4Hg4(C6H7N)2 (3), also resembles that of its pyridine analogue being based on an unusual tetranuclear grouping of mercury atoms linked by chloride and thiolate bridges. Crystals of (3) are monoclinic, P21/c a 12.334(7), b 17.468(9), c 9.999(5) Å, ß 91.18(4)º, Z 2. Crystals of MeSHgBr (4) are monoclinic, P21/c, a 7.770(9), b 7.500(5), c 7.945(10) Å, ß 91.71(3)º, Z 4, and contain parallel chains (-Hg-SMe-)n with neighbouring chains linked by bridging bromine atoms into parallel sheets. Each bromine is triply bridging, being coordinated to two mercury atoms in one chain, and one mercury atom in an adjacent chain. The structure of MeSHgCl appears to be isomorphous.
cag, the Pathogenicity Island ofHelicobacter pylori, Triggers Host Responses (2014)

Helicobacter pylori was isolated by accidental extended incubation. It is a spiral-shaped, gram-negative, microaerophilic microorganism that colonizes and survives in the hostile environment of the human stomach, in an equilibrium that permanently links the parasite to the host. Strains isolated from patients with peptic ulcer disease (PUD) contain the cagA gene (cytotoxin-associated gene A) and express the immunodominant CagA antigen. CagA and VacA are frequently coexpressed; however, their genes are 300 kb apart and VacA expression does not require the presence of the cagA gene, since null cagA mutants still produce the VacA protein. In most industrialized countries, 70 to 80% of the clinical isolates express CagA. Clinical isolates have been grouped into two broad families, type I and type II, in which type I strains possess the cag pathogenicity island (PAI). As with the related Cag proteins of H. pylori, the Icm/Dot proteins act as an exporters for the virulence factor(s) targeted to the intracellular environment to enhance survival and to kill host macrophages. The existence of 30 different proteins all encoded within cag underscores the functional importance of specialized chaperones in macromolecular export. Recent data suggest that VirB4, VirB7, VirB9, VirBlO, and VirB 11 assemble as a complex and form the core of the transporter. The diffusion of H. pylori entails the spread of a population's culture. This was influenced by the history of parasitic association of the bacterium with the human species and the migratory expansion.
Abstract 2500: Left Ventricular Recovery in Peripartum Cardiomyopathy: Impact of Beta Blockade (2007)

Introduction : Peripartum cardiomyopathy (PPCM) remains a major cause of maternal morbidity and mortality. PPCM is associated with acute myocardial dysfunction with a high rate of spontaneous recovery. For subjects with chronic non-ischemic cardiomyopathy, beta blockade (BB) increases left ventricular ejection fraction (LVEF), reverses remodeling and improves survival. The impact of beta blockade (BB) on recovery in acute inflammatory cardiomyopathy is less certain. We investigated the impact of BB on left ventricular recovery in a single center series of women with PPCM. Method: Thirty-six subjects with PPCM referred within the first six months post partum from 1994 to 2006 to the University of Pittsburgh Heart Failure Program were retrospectively reviewed. LVEF and LV diastolic diameter (LVEDD) were assessed by echocardiography at the time of referral (entry) and at approximately 6 and 12 months post partum. Medical therapy was assessed and LV recovery compared by treatment subset. Results: The mean age was 29.7 ± 6.9 years, gravida 2.9 ± 1.9, and para 2.3 ± 0.9. LVEF at presentation was 0.23 ± 0.09. Therapy at entry included ACE inhibitors in 95% of subjects Overall 19 (53%) subjects were not on BB at entry (Group A) while 17 were treated with BB (Group B). BB use differed based on year of presentation with 12% prior to January of 2000 and 80% post on BB therapy. Significant recovery was evident by 12 months by LVEF(0.23 ± 0.09 to 0.41 ± 0.16, p = 0.03)and LVEDD( 5.8 ± 0.9 to 5.3 ± 0.9, p = 0.01). Of note, recovery did not differ significantly by year of presentation or BB therapy(table ). Conclusion : Similar recovery was evident in subjects with PPCM treated with BB and recent historical controls not on therapy. While BB clearly plays an important role in treatment of women with chronic PPCM, they do not appear to enhance the probablity of spontaneous resolution. Impact of Beta Bockade on LV remodeling in PPCM
Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: Evidence for broad based applications (2021)

Bacillus Calmette-Guerin (BCG) vaccinations improve glycemic control in juvenile-onset Type I diabetes (T1D), an effect driven by restored sugar transport through aerobic glycolysis. In a pilot clinical trial, T1D, but not latent autoimmune diabetes of adults (LADA), exhibited lower blood sugars after multidose BCG. Using a glucose transport assay, monocytes from T1D subjects showed a large stimulation index with BCG exposures; LADA subjects showed minimal BCG-induced sugar responsiveness. Monocytes from T1D, type 2 diabetes (T2D), and non-diabetic controls (NDC) were all responsive in vitro to BCG by augmented sugar utilization. Adults with prior neonatal BCG vaccination show accelerated glucose transport decades later. Finally, in vivo experiments with the NOD mouse (a T1D model) and obese db/db mice (a T2D model) confirm BCG's blood-sugar-lowering and accelerated glucose metabolism with sufficient dosing. Our results suggest that BCG's benefits for glucose metabolism may be broadly applicable to T1D and T2D, but less to LADA.
Oxidation State Determination from Chemical Shift Measurements using a Cryogen-Free Microcalorimeter X-Ray Spectrometer on an SEM (2016)

Journal Article Oxidation State Determination from Chemical Shift Measurements using a Cryogen-Free Microcalorimeter X-Ray Spectrometer on an SEM Get access Robin Cantor, Robin Cantor STAR Cryoelectronics Inc., Santa Fe, NM, USA Search for other works by this author on: Oxford Academic Google Scholar Mark P Croce, Mark P Croce Los Alamos National Laboratory, Los Alamos, NM USA Search for other works by this author on: Oxford Academic Google Scholar George J Havrilla, George J Havrilla Los Alamos National Laboratory, Los Alamos, NM USA Search for other works by this author on: Oxford Academic Google Scholar Matthew Carpenter, Matthew Carpenter STAR Cryoelectronics Inc., Santa Fe, NM, USA Search for other works by this author on: Oxford Academic Google Scholar Kathryn McIntosh, Kathryn McIntosh Los Alamos National Laboratory, Los Alamos, NM USA Search for other works by this author on: Oxford Academic Google Scholar Ad Hall, Ad Hall STAR Cryoelectronics Inc., Santa Fe, NM, USA Search for other works by this author on: Oxford Academic Google Scholar Stosh A Kozimor, Stosh A Kozimor Los Alamos National Laboratory, Los Alamos, NM USA Search for other works by this author on: Oxford Academic Google Scholar Hideo Naito, Hideo Naito H.K.N. Inc., San Jose, CA, USA Search for other works by this author on: Oxford Academic Google Scholar Michael W Rabin, Michael W Rabin Los Alamos National Laboratory, Los Alamos, NM USA Search for other works by this author on: Oxford Academic Google Scholar Dan R Schmidt, Dan R Schmidt National Institute of Standards and Technology, Boulder, CO, USA Search for other works by this author on: Oxford Academic Google Scholar ... Show more Daniel Swetz, Daniel Swetz National Institute of Standards and Technology, Boulder, CO, USA Search for other works by this author on: Oxford Academic Google Scholar Joel N Ullom Joel N Ullom National Institute of Standards and Technology, Boulder, CO, USA Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 22, Issue S3, 1 July 2016, Pages 434–435, https://doi.org/10.1017/S1431927616003020 Published: 25 July 2016
CUOGP-95 RANDOMIZED COMPARATIVE STUDY OF 3 VS 8 MONTHS OF NEOADJUVANT HORMONE THERAPY PRIOR TO PROSTATECTOMY: 7 YEAR PSA RELAPSE RATES (2009)

You have accessJournal of Urology1 Apr 2009CUOGP-95 RANDOMIZED COMPARATIVE STUDY OF 3 VS 8 MONTHS OF NEOADJUVANT HORMONE THERAPY PRIOR TO PROSTATECTOMY: 7 YEAR PSA RELAPSE RATES Martin E Gleave, S Larry Goldenberg, Joseph L Chin, Fred Saad, Laurence H Klotz, Michael A s Jewett, Charles Dupont, and Canadian Uro-Oncology Group Martin E GleaveMartin E Gleave More articles by this author , S Larry GoldenbergS Larry Goldenberg More articles by this author , Joseph L ChinJoseph L Chin More articles by this author , Fred SaadFred Saad More articles by this author , Laurence H KlotzLaurence H Klotz More articles by this author , Michael A s JewettMichael A s Jewett More articles by this author , Charles DupontCharles Dupont More articles by this author , and Canadian Uro-Oncology GroupCanadian Uro-Oncology Group More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)62107-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "CUOGP-95 RANDOMIZED COMPARATIVE STUDY OF 3 VS 8 MONTHS OF NEOADJUVANT HORMONE THERAPY PRIOR TO PROSTATECTOMY: 7 YEAR PSA RELAPSE RATES." The Journal of Urology, 181(4S), p. 756 © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 4SApril 2009Page: 756 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetrics Author Information Martin E Gleave More articles by this author S Larry Goldenberg More articles by this author Joseph L Chin More articles by this author Fred Saad More articles by this author Laurence H Klotz More articles by this author Michael A s Jewett More articles by this author Charles Dupont More articles by this author Canadian Uro-Oncology Group More articles by this author Expand All Advertisement PDF downloadLoading ...
Farmbeats: an IoT platform for data-driven agriculture (2017)

Data-driven techniques help boost agricultural productivity by increasing yields, reducing losses and cutting down input costs. However, these techniques have seen sparse adoption owing to high costs of manual data collection and limited connectivity solutions. In this paper, we present FarmBeats, an end-to-end IoT platform for agriculture that enables seamless data collection from various sensors, cameras and drones. FarmBeats's system design that explicitly accounts for weather-related power and Internet outages has enabled six month long deployments in two US farms.
Serum antibody response in experimental human gonorrhoea. Immunoglobulins G, A, and M. (1969)

This report concerns the sequential development of the immunoglobulin response to Neisseria gonorrhoeae in ten human male volunteers who were experimentally infected with virulent organisms during a study on the correlation of virulence with colonial type (Kellogg, Cohen, Norins, Schroeter, and Reising, 1968). An indirect fluorescent antibody (IFA) procedure, using fluorescent antisera specific for human IgG, IgA, and IgM (Ceppellini and others, 1964) antibodies, was used to detect the
Diffractive Optic Laser Resonator (1994)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. R. Leger, D. Chen, G. Mowry, and Z. Wang, "Diffractive Optic Laser Resonator," Optics & Photonics News 5(12), 19_1-20 (1994) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Elevated Linezolid Resistance in Clinical cfr -Positive Staphylococcus aureus Isolates Is Associated with Co-Occurring Mutations in Ribosomal Protein L3 (2010)

Resistance to linezolid (LZD) occurs through mutations in 23S rRNA and ribosomal proteins L3 and L4 or through methylation of 23S rRNA by Cfr. Here we report novel L3 mutations, ΔSer145/His146Tyr and ΔMet169-Gly174, co-occurring with cfr in LZD-resistant Staphylococcus aureus isolates recovered from a hospital outbreak in Madrid, Spain. LZD MIC values (16, 32, or 64 μg/ml) correlated with the presence and severity of the L3 mutation. All isolates had TR-700 (torezolid) MIC values of ≤ 2 μg/ml.
Structural Design Principle of Small‐Molecule Organic Semiconductors for Metal‐Free, Visible‐Light‐Promoted Photocatalysis (2016)

Herein, we report on the structural design principle of small-molecule organic semiconductors as metal-free, pure organic and visible light-active photocatalysts. Two series of electron-donor and acceptor-type organic semiconductor molecules were synthesized to meet crucial requirements, such as 1) absorption range in the visible region, 2) sufficient photoredox potential, and 3) long lifetime of photogenerated excitons. The photocatalytic activity was demonstrated in the intermolecular C-H functionalization of electron-rich heteroaromates with malonate derivatives. A mechanistic study of the light-induced electron transport between the organic photocatalyst, substrate, and the sacrificial agent are described. With their tunable absorption range and defined energy-band structure, the small-molecule organic semiconductors could offer a new class of metal-free and visible light-active photocatalysts for chemical reactions.
Synthesis of Carbon/Sulfur Nanolaminates by Electrochemical Extraction of Titanium from Ti2SC (2015)

Abstract Herein we electrochemically and selectively extract Ti from the MAX phase Ti 2 SC to form carbon/sulfur (C/S) nanolaminates at room temperature. The products are composed of multi‐layers of C/S flakes, with predominantly amorphous and some graphene‐like structures. Covalent bonding between C and S is observed in the nanolaminates, which render the latter promising candidates as electrode materials for Li‐S batteries. We also show that it is possible to extract Ti from other MAX phases, such as Ti 3 AlC 2 , Ti 3 SnC 2 , and Ti 2 GeC, suggesting that electrochemical etching can be a powerful method to selectively extract the “M” elements from the MAX phases, to produce “AX” layered structures, that cannot be made otherwise. The latter hold promise for a variety of applications, such as energy storage, catalysis, etc.
Feasibility study of Global-to-Local Tandem Method for detecting the coronary stationary period in whole-heart magnetic resonance coronary angiography (WH MRCA) (2010)

Introduction WH MRCA studies are usually performed during the stationary period of coronary arteries, which is determined using cine display and therefore depends on the operator's experience. Several automatic methods have been developed. One such method uses the global heart signal for analysis [1] and is suitable for detecting motion during all cardiac phases, but this method tends to suffer from noise. Another method employs a ROI for analysis [2] and is suitable for precise detection of the stationary period, but not for all cardiac phases. We have developed the Global-to-Local Tandem Method, in which the coronary stationary period is roughly analyzed by the global method and then precisely analyzed by the local method. We have also conducted clinical feasibility studies.
Bias-free telecommunication-compatible plasmonic photoconductive terahertz source (Conference Presentation) (2019)

High-power pulsed terahertz radiation sources are highly in demand for time-domain terahertz imaging and spectroscopy systems. A common way to generate pulsed terahertz radiation is exciting a biased ultrafast photoconductor with a femtosecond optical pulse. The photo-generated carriers drift to a terahertz radiating element under the induced bias electric field and a pulsed terahertz radiation is generated. Developing photoconductive terahertz sources operating at telecommunication wavelengths (~1550 nm) is very attractive because of the availability of high-power, narrow-pulse-width, and compact fiber lasers at these wavelengths. However, photoconductors responsive to telecommunication wavelengths often have low resistivity due to their small bandgap energy, resulting in excessive dark current levels under an applied bias voltage. As a result, telecommunication-compatible photoconductive sources experience a premature thermal breakdown under high bias voltages and cannot offer high terahertz radiation powers. To address this limitation, we introduce a new type of telecommunication-compatible photoconductive terahertz source that does not require an externally applied bias voltage and relies on a built-in electric field formed at the interface between the photoconductor and terahertz antenna contact electrodes. By eliminating the bias voltage, the device operates at a zero dark current, enabling a highly reliable operation. We use an array of plasmonic nanoantennas as the terahertz radiating elements to achieve a broad terahertz radiation bandwidth and high optical-to-terahertz conversion efficiency. We demonstrate pulsed terahertz radiation with powers exceeding 100 μW, enabling time-domain terahertz spectroscopy with a 100 dB dynamic range over a 0.1-3 THz bandwidth.
Phase 1 studies of the safety and immunogenicity of electroporated HER2/CEA DNA vaccine followed by adenoviral boost immunization in patients with solid tumors (2013)

Study 1 - ClinicalTrials.gov, NCT00250419; Study 2 - ClinicalTrials.gov, NCT00647114.
Expression and Function of Somatostatin Receptor Subtype 1 in Human Growth Hormone Secreting Pituitary Tumors Deriving from Patients Partially Responsive or Resistant to Long-Term Treatment with Somatostatin Analogs (2004)

The role of somatostatin (SS) receptor subtype 1 (SSTR(1)) in mediating the inhibitory effect of SS on growth hormone (GH) secreting pituitary tumors has been recently demonstrated. In the present study, we evaluated the effect of the selective SSTR(1) agonist BIM-23745 on in vitro GH secretion in GH-secreting pituitary tumor cells, deriving from patients resistant or partially responsive to octreotide long-acting release (octreotide-LAR) or lanreotide therapy in vivo and expressing SSTR(1) mRNA. In addition, the inhibiting effect of BIM-23745 on the GH secretion was compared with that of octreotide. Our data demonstrate that (1) SSTR(1) receptor was present in 56.25% (9/16) of the GH-secreting adenomas examined; (2) in all GH-secreting pituitary tumors that expressed SSTR(1), BIM-23745 significantly inhibited GH secretion in vitro, and (3) when SSTR(1) subtype was present in tumors from patients resistant to octreotide-LAR or lanreotide therapy, BIM-23745 was able to inhibit the in vitro GH secretion. In conclusion, the results of the current study suggest that SS analogs selective for the SSTR(1) may represent a further useful approach for the treatment of acromegaly in patients resistant or partially responsive to octreotide-LAR or lanreotide treatment in vivo.
Potassium carbonate–silica: a highly effective stationary phase for the chromatographic removal of organotin impurities (2010)

Organotin impurities in product mixtures can be reduced from stoichiometric levels to approximately 15 parts per million by column chromatography using 10% w/w anhydrous potassium carbonate-silica as a stationary phase.
An experimental 4Mb CMOS DRAM (1986)

THIS PAPER W-ILL DISCUSS the design of a 49Ib CMOS DRAM that has been fabricated to examine the feasibility of trench cells, new process and circuit technologies, and to investigate reliability problem% such as hot carrier effects and α-particle induced soft errors. The critical problems for future DRAMS and some possible solutions will be reviewed.
A Multichannel Serial Link Receiver With Dual-Loop Clock-and-Data Recovery and Channel Equalization (2013)

This paper presents a four channel receiver for high-speed signal conditioning. Each channel consists of a continuous time linear equalizer (CTLE) and a dual loop CDR with phase-interpolator. All channels share a single PLL that generates and distributes quadrature clock phases to each CDR for data recovery. Clock amplitude, phase INL and phase DNL are derived for IQ phase error and predict phase-dependent jitter contributions to the recovered clock. The multilane receiver was designed in 130-nm CMOS technology. The die occupies an area of 1930 μm by 1250 μm and consumes 67.9 mW per channel. It achieves a maximum data rate of 7 Gbps per channel for 0 and ±200 ppm clock frequency deviation.