gebhart/patrepeval huggingface dataset:
Data from A Somatostatin Receptor Subtype-3 (SST<sub>3</sub>) Peptide Agonist Shows Antitumor Effects in Experimental Models of Nonfunctioning Pituitary Tumors (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Somatostatin analogues (SSA) are efficacious and safe treatments for a variety of neuroendocrine tumors, especially pituitary neuroendocrine tumors (PitNET). Their therapeutic effects are mainly mediated by somatostatin receptors SST&lt;sub&gt;2&lt;/sub&gt; and SST&lt;sub&gt;5&lt;/sub&gt;. Most SSAs, such as octreotide/lanreotide/pasireotide, are either nonselective or activate mainly SST&lt;sub&gt;2&lt;/sub&gt;. However, nonfunctioning pituitary tumors (NFPTs), the most common PitNET type, mainly express SST&lt;sub&gt;3&lt;/sub&gt; and finding peptides that activate this particular somatostatin receptor has been very challenging. Therefore, the main objective of this study was to identify SST&lt;sub&gt;3&lt;/sub&gt;-agonists and characterize their effects on experimental NFPT models.&lt;/p&gt;Experimental Design:&lt;p&gt;Binding to SSTs and cAMP level determinations were used to screen a peptide library and identify SST&lt;sub&gt;3&lt;/sub&gt;-agonists. Key functional parameters (cell viability/caspase activity/chromogranin-A secretion/mRNA expression/intracellular signaling pathways) were assessed on NFPT primary cell cultures in response to SST&lt;sub&gt;3&lt;/sub&gt;-agonists. Tumor growth was assessed in a preclinical PitNET mouse model treated with a SST&lt;sub&gt;3&lt;/sub&gt;-agonist.&lt;/p&gt;Results:&lt;p&gt;We successfully identified the first SST&lt;sub&gt;3&lt;/sub&gt;-agonist peptides. SST&lt;sub&gt;3&lt;/sub&gt;-agonists lowered cell viability and chromogranin-A secretion, increased apoptosis &lt;i&gt;in vitro&lt;/i&gt;, and reduced tumor growth in a preclinical PitNET model. As expected, inhibition of cell viability in response to SST&lt;sub&gt;3&lt;/sub&gt;-agonists defined two NFPT populations: responsive and unresponsive, wherein responsive NFPTs expressed more SST&lt;sub&gt;3&lt;/sub&gt; than unresponsive NFPTs and exhibited a profound reduction of MAPK, PI3K-AKT/mTOR, and JAK/STAT signaling pathways upon SST&lt;sub&gt;3&lt;/sub&gt;-agonist treatments. Concurrently, &lt;i&gt;SSTR3&lt;/i&gt; silencing increased cell viability in a subset of NFPTs.&lt;/p&gt;Conclusions:&lt;p&gt;This study demonstrates that SST&lt;sub&gt;3&lt;/sub&gt;-agonists activate signaling mechanisms that reduce NFPT cell viability and inhibit pituitary tumor growth in experimental models that expresses SST&lt;sub&gt;3&lt;/sub&gt;, suggesting that targeting this receptor could be an efficacious treatment for NFPTs.&lt;/p&gt;&lt;/div&gt;
Diseño de antenas multibanda para telefonía móvil mediante la manipulación del plano de masa (2007)

The Ground Plane used in a handset device has\na very important role in the behaviour of the antenna.\nThis study consists on a Ground Plane modification in\norder to enhance bandwidth and design a multiband\nantenna. Through this technique is possible to improve\nmatching and antenna efficiency while keeping the\noriginal volume of the PIFA antenna (Planar Inverted-F\nAntenna).
Stepwise Dosing Protocol for Increased Throughput in Label-Free Impedance-Based GPCR Assays (2020)

Label-free impedance-based assays are increasingly used to non-invasively study ligand-induced GPCR activation in cell culture experiments. The approach provides real-time cell monitoring with a device-dependent time resolution down to several tens of milliseconds and it is highly automated. However, when sample numbers get high (e.g., dose-response studies for various different ligands), the cost for the disposable electrode arrays as well as the available time resolution for sequential well-by-well recordings may become limiting. Therefore, we here present a serial agonist addition protocol which has the potential to significantly increase the output of label-free GPCR assays. Using the serial agonist addition protocol, a GPCR agonist is added sequentially in increasing concentrations to a single cell layer while continuously monitoring the sample's impedance (agonist mode). With this serial approach, it is now possible to establish a full dose-response curve for a GPCR agonist from just one single cell layer. The serial agonist addition protocol is applicable to different GPCR coupling types, Gq Gi/0 or Gs and it is compatible with recombinant and endogenous expression levels of the receptor under study. Receptor blocking by GPCR antagonists is assessable as well (antagonist mode).
The interaction between preoperative platelet count and function and its relationship with postoperative bleeding in cardiac surgery (2017)

Platelet function tests (PFTs) before cardiac surgery are predictive of postoperative bleeding and can guide a correct timing of surgery in patients under P<sub>2</sub>Y<sub>12</sub> inhibitors. Thrombocytopenia affects PFT and may determine postoperative bleeding. The present study aims to investigate the relationship between platelet count and function, and its role in determining postoperative bleeding in cardiac surgery patients pre-treated with P<sub>2</sub>Y<sub>12</sub> inhibitors. The study includes 589 consecutive cardiac surgery patients, tested before surgery with platelet count and multiple electrode aggregometry (MEA) ADPtest (investigating P<sub>2</sub>Y<sub>12</sub> receptor platelet reactivity) and TRAPtest (investigating the thrombin-dependent platelet reactivity). Platelet function was linearly associated (P = 0.001) with platelet count at the ADPtest and the TRAPtest, demonstrating a positive association in the whole spectrum of platelet count. The ADPtest (P = 0.001) and platelet count (P = 0.001) were negatively associated with postoperative bleeding, whereas the TRAPtest was not. At a multivariable analysis, the ADPtest (P = 0.026) and platelet count (P = 0.006) remained independent predictors of postoperative bleeding. The platelet transfusion rate was 5.7% in patients with ADPtest ≥30 U and platelet count ≥150 000 cells/µL, 14.3% in patients with ADPtest ≥30 U and platelet count <150 000 cells/µL, 38.9% in patients with ADPtest <30 U and platelet count ≥150 000 cells/µL, and 50% in patients with ADPtest <30 U and platelet count <150 000 cells/µL (P = 0.001). Platelet function at MEA is dependent on the platelet count not only in the case of thrombocytopenia, but also in the whole range of platelet count; preoperative platelet count and function are determinants of postoperative bleeding, with a larger effect on platelet transfusions attributable to a poor P<sub>2</sub>Y<sub>12</sub>-dependent platelet function.
Hollow nanoporous covalent triazine frameworks via acid vapor-assisted solid phase synthesis for enhanced visible light photoactivity (2016)

Herein, we report a novel trifluoromethanesulfonic acid vapor-assisted solid phase synthetic method to construct nanoporous covalent triazine frameworks with highly ordered hollow interconnected pores under mild reaction conditions.
Association of TwoBactericeraSpecies (Hemiptera: Triozidae) With NativeLyciumspp. (Solanales: Solanaceae) in the Potato Growing Regions of the Rio Grande Valley of Texas (2022)

Bactericera cockerelli (Šulc) (Hemiptera: Triozidae) is a vector of 'Candidatus Liberibacter solanacearum' (Lso), the pathogen that causes potato zebra chip. Zebra chip incidence varies regionally, perhaps because of geographic differences in species of noncrop hosts available to the vector and in susceptibility of those hosts to Lso. Native and introduced species of Lycium (Solanales: Solanaceae) are important noncrop hosts of B. cockerelli in some regions of North America. Susceptibility of native Lycium species to Lso is uncertain. We investigated the use of two native species of Lycium by B. cockerelli in South Texas and tested whether they are susceptible to Lso. Bactericera cockerelli adults and nymphs were collected frequently from L. berlandieri Dunal and L. carolinianum Walter. Greenhouse assays confirmed that B. cockerelli develops on both species and showed that Lso infects L. carolinianum. Molecular gut content analysis provided evidence that B. cockerelli adults disperse between potato and Lycium. These results demonstrate that L. berlandieri and L. carolinianum are likely noncrop sources of potato-colonizing B. cockerelli in South Texas and that L. carolinianum is a potential source of Lso-infected psyllids. We also routinely collected the congeneric psyllid, Bactericera dorsalis (Crawford), from both Lycium species. These records are the first for this psyllid in Texas. Bactericera dorsalis completed development on both native Lycium species, albeit with high rates of mortality on L. berlandieri. B. dorsalis acquired and transmitted Lso on L. carolinianum under greenhouse conditions but did not transmit Lso to potato. These results document a previously unknown vector of Lso.
Profit Driven User Association with Dual Batteries in Green Heterogeneous Cellular Networks (2017)

Owing to the impact of greenhouse gases on the environment and climate change, the on-grid energy consumption of Information and Communications Technology (ICT) has received much attention in recent years. Cellular networks are among the major energy guzzlers in ICT, and their contributions to the global energy consumption increase rapidly. In cellular networks, base stations (BSs) account for more than 50 percent of the energy consumption. Utilizing green energy to power BSs is essential to save the on-grid energy and reduce the electricity expenditure of the network providers. However, in order to furthest save on-gird energy, most existing works only focus on maximizing the green energy utilization, while compromising the services received by the mobile users. In fact, dissatisfaction of services eventually leads to loss of market shares and profits of the network providers. Therefore, we propose a novel profit driven user association scheme for green heterogeneous cellular networks by jointly considering the green energy utilization and traffic delivery latency to maximize the profit of the network providers. Since this profit driven user association problem is NP-hard, we further propose some heuristics to maximize the profit with low computational complexity. Finally, we validate the performance of the proposed algorithm through extensive simulations.
Abstract A081: Phase I study of mesothelin-targeted immunotoxin LMB-100 given as a long infusion (2019)

Abstract Purpose: LMB-100 recombinant immunotoxin consists of a mesothelin-binding Fab for targeting and a modified Pseudomonas exotoxin A payload. Previous Phase 1 clinical testing of a 30-minute LMB-100 infusion format identified dose-limiting toxicity (DLT) of capillary leak syndrome (CLS) and a serum half-life of ~60 minutes. Pre-clinical data suggested that extending infusion time could improve anti-tumor efficacy by increasing tumor cell duration of exposure to LMB-100. The primary objective of this study was to determine the safety and tolerability of administering LMB-100 over a longer infusion time. We hypothesized that reduced CMAX would result in decreased severity of off-target toxicities like CLS without decreasing anti-tumor activity. Patients and Methods: Patients (n = 15) with pancreatic adenocarcinoma and other mesothelin-expressing solid tumors (n = 3; mesothelioma, colon adenocarcinoma, ampullary carcinoma) treated on 3 dose levels received long infusion (24-48 hours) LMB-100 (65 or 100 mcg/kg/day) with or without a loading dose (40 mcg/kg over 30 minutes) for up to 2 cycles. Safety and tolerability, pharmacokinetics, immunogenicity and anti-tumor activity were assessed. Results: DLT of proteinuria (grade 3) was observed in 1 of 6 patients receiving 100 mcg/kg/day over 48 hours with pre-load. Three of 6 patients at this dose level developed significant CLS (&amp;gt;5 kg weight gain from fluid edema) that was not dose-limiting. No CLS was observed in the 6 patients who received 100 mcg/kg over 24 hours on days 1 and 4 with pre-load. Increased immunogenicity was observed with the long infusion compared to standard administration format: 8 of 9 patients receiving 2nd cycle treatment had undetectable plasma LMB-100 concentration during this cycle that was associated with the development of high titer anti-LMB-100 antibodies. Progressive disease was observed in 11 of 12 evaluable patients, and none of 8 evaluable patients with pancreatic adenocarcinoma had a clinically significant decline in CA 19-9 tumor marker. Conclusions: Long infusion format of delivery for LMB-100 can reduce CLS but increases immunogenicity. No anti-tumor activity was observed. Citation Format: Christine Alewine, Mehwish Iqra Ahmad, Cody J Peer, Seth Steinberg, William D Figg, Raffit Hassan, Ira Pastan. Phase I study of mesothelin-targeted immunotoxin LMB-100 given as a long infusion [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics; 2019 Oct 26-30; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2019;18(12 Suppl):Abstract nr A081. doi:10.1158/1535-7163.TARG-19-A081
Novel roles of complement in systemic lupus erythematosus--hypothesis for a pathogenetic vicious circle. (2000)

We propose that impaired complement function enhances a pathogenetic vicious circle in SLE. In this process, induction and clearance of apoptotic cells is central. Apoptosis could be triggered by various etiological factors, such as infection, UV light, and drug reactions. Clearance of apoptotic material is reduced when complement function is impaired. Apoptosis leads to increased exposure of nuclear antigens to the immune system, to which estrogenic hormones could contribute. This could in turn lead to activation of autoreactive B cells, autoantibody production, and immune complex formation, all of which is accelerated by hypocomplementemia. Immune complexes may, at least partly via complement dependent mechanisms, accelerate apoptosis.
Using Cross Stamping to Test Zinc Sheets Formability (2012)

Sheet metal formability has been studied for a half century. The sheet formability is mostly described by the Forming Limit Diagram (FLD). A prediction of this FLD is a source of interest for industrial companies. Indeed knowing the FLD of a material allows optimization of the production processes which leads to money saving. Nevertheless, the formability tests (tensile, bulge and Nakazima tests) which give the experimental FLD do not really represent the process that the sheet will undergo in industrial conditions. The paper therefore focuses on a cross stamping test. The material of interest is a Zinc sheet. FLD prediction is reported for a wide variety of metals [1] but literature about Zinc is nearly non existent. The studied Zinc sheets exhibit a highly anisotropic mechanical behaviour due to the hcp lattice structure and the inherited rolling texture. This anisotropic behaviour results in an anisotropic formability. The Zinc sheet FLD is influenced by the orientation of the rolling direction during the process. Experimental cross stamping of this material allows describing the studied material behaviour in a large range of mechanical solicitations from tensile to biaxial tension. The experimental results are compared with the finite element simulation and permit to understand where and why failures appear, which leads to a better understanding of Zinc anisotropic formability.
Comparison of Healing after Cystotomy and Repair with Fibrin Glue and Sutured Closure in the Porcine Model (2008)

Purpose: We compared healing after laparoscopic cystotomy using fibrin glue, sutures, or a combination to determine whether fibrin glue can obviate the need for sutures and whether there is any detriment when glue is used in the presence of sutures. Materials and Methods: In 24 Yorkshire pigs, a 3.5 cm vertical cystotomy was created laparoscopically and repaired as follows: Group 1—no closure; group 2—fibrin glue closure; group 3—suture repair; group 4— combined fibrin glue and suture repair. All animals had a Foley catheter for 1 week. In each group, three animals were harvested at 1 week (acute) and three animals were harvested at 6 weeks (chronic). Results: Acute: Group 1—all pigs had an unhealed defect that leaked when evaluated by cystography. Groups 2, 3, 4—mean leak pressures were 80, 97, and 60 cm H2O (P = 0.36), respectively. Mean bladder capacity was not significantly different between groups. Chronic: No leakage seen on a cystogram at 1 week; at 6 weeks, bladders were filled at ≥95 to 100 cm H2O without leakage. Histologically, there was more inflammation in the acute group v chronic group pigs. In the acute group pigs repaired with glue or suture + glue, there was more inflammation and less epithelial continuity than in the suture alone group. At 6 weeks, there was no difference between groups. Conclusion: Fibrin glue provoked an intense inflammatory response that might have delayed healing acutely, resulting in a lower burst pressure in both scenarios in which it was used (i.e., alone or in combination with sutures). However, by 6 weeks, there did not seem to be any difference between groups either clinically or histopathologically.
Expression of the Human Germinal Center Associated Lymphoma (HGAL) Protein Identifies a Subset of Classical Hodgkin Lymphoma of Germinal Center Derivation and Improved Outcome. (2005)

Abstract Classical Hodgkin lymphoma (CHL) exhibit crippled somatic mutations in rearranged Ig genes and an immunophenotype unlike any other hematolymphoid malignancy. Expression profiles of CHL cell lines show that CHL is most closely related to EBV-transformed peripheral blood B-cells with marked loss of B lineage-specific gene expression. The Human Germinal center-Associated Lymphoma (HGAL) gene was identified as a candidate molecule that predicted improved outcome in diffuse large B-cell lymphoma. Previously, we showed that HGAL mRNA and protein are expressed specifically in germinal centers (GC), GC-derived lymphomas and a substantial proportion of CHL. Here, we sought to investigate whether HGAL protein expression could serve to distinguish biologically distinct subgroups of CHL. Ninety informative cases of CHL on a tissue microarray of 1.0 mm representative cores of paraffin embedded tissue were used. Staining was performed and the percent of stained Hodgkin cells was scored on a 3-tiered scale as negative (0%), weak (&amp;lt;30%), and strong (&amp;gt;30%), as previously described (Natkunam et al. Blood 2005, 105:3979–86). These cutoffs were chosen before results were correlated with clinical endpoints. Twenty-five patients (28%) showed no staining for HGAL and 25 patients (28%) had weak staining; HGAL was strongly expressed in 40 patients (44%). Thirteen of the 90 patients had died and 19 had failed (i.e. relapsed or died). The overall 5-year survival (OS) and failure-free survival (FFS) rates were 87% + 4% and 79% + 4%, respectively. HGAL expression was associated with improved OS in univariate analysis (p=0.04, no vs weak/strong staining), as were age &amp;lt; 45 years (p&amp;lt;0.001), stage I or II (p=0.02), and possibly histology (nodular sclerosing vs other, p=0.09). However, in multivariate analysis with age, stage and histology, HGAL expression no longer had an impact (p=0.93). HGAL did not impact FFS in either univariate (p=0.13) or multivariate analysis (p=0.87). The expression of the GC-specific marker HGAL in a subset of CHL suggests that a substantial proportion of CHL retain characteristics of lymphomas of GC derivation. The association with improved OS in univariate but not multivariate analysis suggests HGAL may be a biologic marker related to known clinical parameters of improved OS and FFS. Comparative studies with well-characterized GC markers, BCL6 and CD10, and with BCL2, MUM1 and Blimp-1 are underway to further define biologically distinct subsets of CHL. Analysis of additional cases of CHL is also on-going to substantiate these findings in multivariate analysis.
Curcuma longa and Boswellia serrata extract combination for hand osteoarthritis: an open-label pre-post trial (2022)

This is the first clinical trial showing that <i>C. longa</i> and <i>B. serrata</i> resin can relieve symptoms in patients with hand osteoarthritis. The study provides useful information for the design of a clinical trial including a broader population.
Radiative collision-induced electron continuum-continuum scattering (1983)

The photoionization of an atom is examined in the presence of a foreign atom. We find that a two-photon radiative collision process induces large cross sections for electron continuum-continuum scattering. The enhancement is caused by an intensity-induced collisional shift which, when used to cancel out the collisional dephasing between the initial and final scattering states at wide range of internuclear separations, enhances the electron continuum-continuum scattering process.
The Change in Your Pocket (2021)

In recounting her experience of being asked the ‘Bitcoin Question’, Lana Swartz reveals that her response to friends and family enquiring about the risks of getting in on the cryptocurrency game is to ask what they want to achieve through their acquisition.1 Simply put: what are all the Bitcoins for? The typical answers to Swartz’s provocation are both achingly dull and easily anticipated. People have heard of others making decent returns by speculating on Bitcoin rallies and want to get in on the action. In other words, the primary motivation of those who want to acquire Bitcoins is to use them to acquire more Bitcoins, which at some point in the future will have risen to a price deemed high enough to ‘cash out’ via a fiat currency of choice. At the exit point of sale, after all, nobody imagines selling their Bitcoins for more Bitcoins. The more imaginative would-be speculators answer in ways that reveal a growing sense of existential threat. As political, social and economic institutions lurch from one catastrophe to the next, at least they are providing a distraction from the impending world-ending breakdown of the climate. In short, if Bitcoin is to be the only non-institutionalized global currency within a matter of decades, doesn’t it make sense to start hoarding them now? In both responses, we can see the same instincts that drive people to save money. A desire to have more of it stored up against an uncertain future makes a good deal of sense from one point of view.
An exploration strategy improves the diversity of de novo ligands using deep reinforcement learning: a case for the adenosine A2A receptor (2019)

Over the last 5 years deep learning has progressed tremendously in both image recognition and natural language processing. Now it is increasingly applied to other data rich fields. In drug discovery, recurrent neural networks (RNNs) have been shown to be an effective method to generate novel chemical structures in the form of SMILES. However, ligands generated by current methods have so far provided relatively low diversity and do not fully cover the whole chemical space occupied by known ligands. Here, we propose a new method (DrugEx) to discover de novo drug-like molecules. DrugEx is an RNN model (generator) trained through reinforcement learning which was integrated with a special exploration strategy. As a case study we applied our method to design ligands against the adenosine A<sub>2A</sub> receptor. From ChEMBL data, a machine learning model (predictor) was created to predict whether generated molecules are active or not. Based on this predictor as the reward function, the generator was trained by reinforcement learning without any further data. We then compared the performance of our method with two previously published methods, REINVENT and ORGANIC. We found that candidate molecules our model designed, and predicted to be active, had a larger chemical diversity and better covered the chemical space of known ligands compared to the state-of-the-art.