gebhart/patrepeval huggingface dataset:
Exact and approximate polynomial decomposition methods for signal processing applications (2013)

Signal processing is a discipline in which functional composition and decomposition can potentially be utilized in a variety of creative ways. From an analysis point of view, further insight can be gained into existing signal processing systems and techniques by reinterpreting them in terms of functional composition. From a synthesis point of view, functional composition offers new algorithms and techniques with modular structure. Moreover, computations can be performed more efficiently and data can be represented more compactly in information systems represented in the context of a compositional structure. Polynomials are ubiquitous in signal processing in the form of z-transforms. In this paper, we summarize the fundamentals of functional composition and decomposition for polynomials from the perspective of exploiting them in signal processing. We compare exact polynomial decomposition algorithms for sequences that are exactly decomposable when expressed as a polynomial, and approximate decomposition algorithms for those that are not exactly decomposable. Furthermore, we identify efficiencies in using exact decomposition techniques in the context of signal processing and introduce a new approximate polynomial decomposition technique based on the use of Structured Total Least Norm (STLN) formulation.
Multicamera Information Processing: Acquisition, Collaboration, Interpretation, and Production (2010)

Reference EPFL-ARTICLE-171979doi:10.1155/2010/560927View record in Web of Science Record created on 2011-12-16, modified on 2017-05-10
Causes and consequences of child growth faltering in low- and middle-income countries (2020)

Summary Growth faltering (low length-for-age or weight-for-length) in the first 1000 days — from conception to two years of age — influences short and long-term health and survival. Interventions such as nutritional supplementation during pregnancy and the postnatal period could help prevent growth faltering, but programmatic action has been insufficient to eliminate the high burden of stunting and wasting in low- and middle-income countries. Future preventive efforts will benefit from understanding age-windows and population subgroups in which to focus. Here, we use a population intervention effects analysis of 33 longitudinal cohorts (83,671 children, 662,763 measurements) and 30 separate exposures to show that improving maternal anthropometry and child condition at birth accounted for population increases in length-for-age Z of up to 0.40 and weight-for-length Z of up to 0.15 by age 24 months. Boys had consistently higher risk of all forms of growth faltering than girls. Early post-natal growth faltering predisposed children to subsequent and persistent growth faltering. Children with multiple growth deficits had higher mortality rates from birth to two years than those without deficits (hazard ratios 1.9 to 8.7). The importance of prenatal causes, and severe consequences for children who experienced early growth faltering, support a focus on pre-conception and pregnancy as key opportunities for new preventive interventions.
Process-structure-property relationships in laser powder bed fusion of permanent magnetic Nd-Fe-B (2021)

Laser powder-bed fusion (L-PBF), as an additive manufacturing (AM) technique, has demonstrated excellent capabilities in achieving degrees of freedom in manufacturing that are otherwise unattainable. The potential of combining Nd-Fe-B as a permanent magnet and the manufacturing capabilities of L-PBF promises new prospects for functional AM in applications such as electric machines. In this study, high density L-PBF Nd-Fe-B samples (91%) with remanence of 0.65 T and maximum energy product of 62 kJ/m3 were successfully produced, comparable to the state-of-the-art in this field. A parametric study correlating the integrity of the parts to the process parameters, such as, the scan speed and hatch distance is presented. From a metallurgy perspective, the microstructure of the additively manufactured samples was different from the conventionally-sintered material. Interestingly, similarities to the microstructures of laser spot welded material were observed. The fabricated magnets mainly consisted of Nd2Fe14B with small fractions of precipitated phases and suffered from the presence of cracks at input energies sufficient for powder fusion. The relative density and integrity was constrained by the intrinsic brittle nature of the intermetallic Nd2Fe14B phase, the high energy input required to melt some phases, as well as the rapid heating and cooling rates experienced during processing.
2-Substitution of Adenine Nucleotide Analogues Containing a Bicyclo[3.1.0]hexane Ring System Locked in a Northern Conformation: Enhanced Potency as P2Y 1 Receptor Antagonists (2020)

Preference for the northern (N) ring conformation of the ribose moiety of adenine nucleotide 3′,5′-bisphosphate antagonists of P2Y1 receptors was established by using a ring-constrained methanocarba (a bicyclo[3.1.0]hexane) ring as a ribose substitute (Nandanan et al. J. Med. Chem. 2000, 43, 829–842). We have now combined the ring-constrained (N)-methanocarba modification with other functionalities at the 2-position of the adenine moiety. A new synthetic route to this series of bisphosphate derivatives was introduced, consisting of phosphorylation of the pseudoribose moiety prior to coupling with the adenine base. The activity of the newly synthesized analogues was determined by measuring antagonism of 2-methylthio-ADP-stimulated phospholipase C (PLC) activity in 1321N1 human astrocytoma cells expressing the recombinant human P2Y1 receptor and by using the radiolabeled antagonist [3H]2-chloro-N6-methyl-(N)-methanocarba-2′-deoxyadenosine 3′,5′-bisphosphate 5 in a newly developed binding assay in Sf9 cell membranes. Within the series of 2-halo analogues, the most potent molecule at the hP2Y1 receptor was an (N)-methanocarba N6-methyl-2-iodo analogue 12, which displayed a Ki value in competition for binding of [3H]5 of 0.79 nM and a KB value of 1.74 nM for inhibition of PLC. Thus, 12 is the most potent antagonist selective for the P2Y1 receptor yet reported. The 2-iodo group was substituted with trimethyltin, thus providing a parallel synthetic route for the introduction of an iodo group in this high-affinity antagonist. The (N)-methanocarba-2-methylthio, 2-methylseleno, 2-hexyl, 2-(1-hexenyl), and 2-(1-hexynyl) analogues bound less well, exhibiting micromolar affinity at P2Y1 receptors. An enzymatic method of synthesis of the 3′,5′-bisphosphate from the corresponding 3′-monophosphate, suitable for the preparation of a radiophosphorylated analogue, was explored.
Influence of hyperprolactinaemia on ovarian function in infertile women with normal menstrual rhythm [proceedings]. (1978)

Design equations for the input impedance of the asymmetric strip folded dipole, developed by Lampe, [2,3], depend, amongst others, on the characteristic impedance of an asymmetric coplanar strip (CPS) transmission line. Lampe assumes a homogeneous surrounding medium. In practice, the antenna will be realised on a dielectric slab. Employing the Lampe equations for this inhomogeneous case may lead to relative errors in the CPS characteristic impedance as much as 32% and therefore to large errors in the input impedance. Improved design equations for the input impedance are discussed for the inhomogeneous case. These improved design equations rely on an accurate calculation of the characteristic impedance of an asymmetric CPS on a dielectric slab and further employ correction factors applied to the homogeneous case dipole length and equivalent radius.
Use of the artificial larynx during airway intubation (1974)

Department of Anesthesiology, West Virginia University Medical Center, Morgantown, West Virginia 26506. The present address of Dr. Wu and Dr. Turndorf: Department of Anesthesiology, New York University Medical Center, New York, N.Y. 10016.
Design of an Ankle Rehabilitation Device Using Compliant Mechanisms (2011)

In this paper, we present the design, analysis, and testing of an ankle rehabilitation device (ARD), the purpose of which is to improve the efficacy of ankle joint complex (AJC) injury diagnosis and treatment. The ARD enables physicians to quantitatively measure the severity of an injury. This is done by measuring deficiencies in the joint’s range of motion, as well as force, torque, and power output. Evaluation of the relative degree of recovery over time can also reduce the error associated with current methodologies for rehabilitation, which rely on measurements based on the patient’s verbal response. A Wheatstone bridge circuit is used for the measurement of the various parameters as applied to the blades of complementary rotational flexures; the device is designed to measure motion about three axes of rotation in the ankle joint: pitch, roll, and yaw. A full bridge circuit is applied to each axis of rotation, and the use of multiple axes increases anatomically accurate measurement, enabling characterization of coupled motions. The device has flexibility and a range of motion such that it can be adjusted to take measurements of multiple different degrees of plantar or dorsiflexion of the AJC. The ARD is able to measure both range of motion, force, and torque output simultaneously. Experimental results show that there is significant coupled motion among the ankle joint rotations but that it is highly dependent on a subject’s own physical development.
Maternal sympathetic stress impairs follicular development and puberty of the offspring (2014)

Chronic cold stress applied to adult rats activates ovarian sympathetic innervation and develops polycystic ovary (PCO) phenotype. The PCO syndrome in humans originates during early development and is expressed before or during puberty, which suggests that the condition derived from in utero exposure to neural- or metabolic-derived insults. We studied the effects of maternal sympathetic stress on the ovarian follicular development and on the onset of puberty of female offspring. Timed pregnant rats were exposed to chronic cold stress (4 °C, 3 h/daily from 1000 to 1300 h) during the entire pregnancy. Neonatal rats exposed to sympathetic stress during gestation had a lower number of primary, primordial, and secondary follicles in the ovary and a lower recruitment of primary and secondary follicles derived from the primordial follicular pool. The expression of the FSH receptor and response of the neonatal ovary to FSH were reduced. A decrease in nerve growth factor (NGF) mRNA was found without change in the low-affinity NGF receptor. The FSH-induced development of secondary follicles was decreased. At puberty, estradiol plasma levels decreased without changes in LH plasma levels. Puberty onset (as shown by the vaginal opening) was delayed. Ovarian norepinephrine (NE) was reduced; there was no change in its metabolite, 3-methoxy-4-hydroxyphenylglycol, in stressed rats and no change in NE turnover. The changes in ovarian NE in prepubertal rats stressed during gestation could represent a lower development of sympathetic nerves as a compensatory response to the chronically increased NE levels during gestation and hence participate in delaying reproductive performance in the rat.
A Framework for Big Data Sovereignty: The European Industrial Data Space (EIDS) (2022)

Abstract The path that the European Commission foresees to leverage data in the best possible way for the sake of European citizens and the digital single market clearly addresses the need for a European Data Space. This data space must follow the rules, derived from European values. The European Data Strategy rests on four pillars: (1) Governance framework for access and use; (2) Investments in Europe’s data capabilities and infrastructures; (3) Competences and skills of individuals and SMEs; (4) Common European Data Spaces in nine strategic areas such as industrial manufacturing, mobility, health, and energy. The project BOOST 4.0 developed a prototype for the industrial manufacturing sector, called European Industrial Data Space (EIDS), an endeavour of 53 companies. The publication will show the developed architectural pattern as well as the developed components and introduce the required infrastructure that was developed for the EIDS. Additionally, the population of such a data space with Big Data enabled services and platforms is described and will be enriched with the perspective of the pilots that have been build based on EIDS.
Solid state thermal degradation products of rosaramicin. (1992)

The structures of two solid-state rearrangement products, A and B, of rosaramicin have been assigned on the basis of 13C NMR spectral data and a single-crystal X-ray analysis of the acetone solvate of product B.
Crystallization and X-ray analysis of the catalytic domain of human PDE 3B (2005)

of the HIV protease flaps and the process of inhibitor unbinding using molecular dynamics (Amber, Oral) [2] under influence of external forces (with variable magnitudes and directions) making the system pass through different conformations in a reasonable computer time. Energies of individual components of the system were monitored to judge on feasibility of the states acquired. For unliganded protease, the flaps can accommodate a large range of opened conformations allowing direct entry of inhibitor into the binding cleft. Therefore, the protease without inhibitor is in a relaxed state with its flaps in large spectrum of conformations of similar energy. On the complexation the protease flaps close over the inhibitor as necessary and thus can accommodate inhibitors of different sizes. Forced unbinding of inhibitor simulated with HIV protease in a "water box" shows that the flaps stick to the inhibitor and follow it up to a large distance from the protein. The energy profiles show that the process of unbinding has many steps and must be slow relatively to the natural movement of the flaps to keep their deformation energies low. The project was supported by GA AV CR KJB4050312 and MSMT 1K05008.
Candidate variants in DNA replication and repair genes in early-onset renal cell carcinoma patients referred for germline testing (2023)

Together, these results suggest that constitutional defects in DNA repair underlie a subset of eoRCC cases. Screening patient lymphocytes to identify these defects may provide insight into mechanisms of carcinogenesis in a subset of genetically undefined eoRCCs. Evaluation of DNA repair defects may also provide insight into the cancer initiation mechanisms for subsets of eoRCCs and lay the foundation for targeting DNA repair vulnerabilities in eoRCC.
Phase Compensated Sequential Load Modulated Balanced Amplifier Using Harmonically Tuned Control Amplifier (2022)

This paper presents a new solution for phase compensation in the sequential load modulated balanced amplifier (SLMBA). It is illustrated that, by using proper harmonic tuning in the control amplifier branch, the load trajectory of the balanced amplifier can be made close to the real axis, which is beneficial to recover peak power and efficiency at both back-off and saturation of the SLMBA in wideband operation. To validate the idea, a wideband prototype operating from 1.9 to 2.6 GHz was designed. Measured drain efficiency of 61.0% to 66.5% at peak power and 53.2% to 64.1% at 8-dB back-off are achieved. When driven with a 60-MHz long-term evolution signal with an 8-dB peak-to average power ratio, the proposed SLMBA achieves over 52% average drain efficiency, and better than −45-dBc adjacent channel power ratio with digital predistortion.
Kerfless Epitaxial Mono Crystalline Si Wafers With Built-In Junction and From Reused Substrates for High-Efficiency PERx Cells (2016)

This paper proposes a kerfless wafer structure with built-in p-n junctions in n-type silicon wafers grown using Crystal Solar's high throughput epitaxy technology. Compared with a conventional p-type emitter by boron diffusion, ion implantation, or epitaxy, the built-in p-type emitter has a reduced and uniform doping concentration and increased thickness. The epitaxially grown wafers and conventional Czochralski (CZ) n-type wafers were processed into solar cells. A best efficiency of 22.5% with epitaxially grown wafers was achieved, with a 6 mV gain in open-circuit voltage, suggesting a high wafer quality and superiority of the deep epitaxial emitter over a standard boron-diffused emitter. Substrate reuse associated with the kerfless epitaxy technology is studied as well, with respect to its impact on solar cell efficiency. The data suggest no degradation in cell efficiency due to substrate reuse.
Introducing the Journal of Chemical Theory and Computation (2004)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTIntroducing the Journal of Chemical Theory and ComputationWilliam L. JorgensenView Author Information EditorCite this: J. Chem. Theory Comput. 2005, 1, 1, 1Publication Date (Web):October 21, 2004Publication History Published online21 October 2004Published inissue 1 January 2005https://pubs.acs.org/doi/10.1021/ct040003shttps://doi.org/10.1021/ct040003seditorialACS PublicationsCopyright © 2005 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1612Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (8 KB) Get e-AlertscloseSUBJECTS:Ab initio molecular dynamics,Solvation dynamics,Surface science Get e-Alerts
Center frequency, bandwidth, and transfer function tunable bandpass filter using ring resonator and J-inverter (2009)

This paper proposes a tunable bandpass filter that can tune its center frequency, bandwidth, and transfer function. The filter comprises tunable ring resonators and tunable J-inverters. The tunable ring resonator can change its susceptance slope parameter independently of its resonant frequency. This feature helps us to change the bandwidth and transfer function of the filter while keeping the center frequency constant. The center frequency of the filter is also tuned by the tunable resonator. The tunable J-inverter maintains its phase difference between two adjacent tunable ring resonators of 90 degrees at the resonant frequency of the tunable resonator even if the tunable resonator varies its resonant frequency. This paper also presents an ideal tuning scheme for a tunable three-pole bandpass filter and the measured characteristics for the fabricated filter. Experimental results validate the feasibility of the proposed tunable filter architecture.
Final report :LDRD project 84269 supramolecular structures of peptide-wrapped carbon nanotubes. (2006)

Carbon nanotubes (CNT) are unique nanoscale building blocks for a variety of materials and applications, from nanocomposites, sensors and molecular electronics to drug and vaccine delivery. An important step towards realizing these applications is the ability to controllably self-assemble the nanotubes into larger structures. Recently, amphiphilic peptide helices have been shown to bind to carbon nanotubes and thus solubilize them in water. Furthermore, the peptides then facilitate the assembly of the peptide-wrapped nanotubes into supramolecular, well-aligned fibers. We investigate the role that molecular modeling can play in elucidating the interactions between the peptides and the carbon nanotubes in aqueous solution. Using ab initio methods, we have studied the interactions between water and CNTs. Classical simulations can be used on larger length scales. However, it is difficult to sample in atomistic detail large biomolecules such as the amphiphilic peptide of interest here. Thus, we have explored both new sampling methods using configurational-bias Monte Carlo simulations, and also coarse-grained models for peptides described in the literature. An improved capability to model these inorganichiopolymer interfaces could be used to generate improved understanding of peptide-nanotube self-assembly, eventually leading to the engineering of new peptides for specific self-assembly goals.
Model-Based Trust Assessment for Internet of Things Networks (2018)

Trust in data collected by and passing through Internt of Things (IoT) networks is paramount. The quality of decisions made based on this collected data is highly dependent upon the accuracy of the data. Currently, most trust assessment methodologies assume that collected data follows a stationary Gaussian distribution. Often, a trust score is estimated based upon the deviation from this distribution. However, the underlying state of a system monitored by an IoT network can change over time, and the data collected from the network may not consistently follow a Gaussian distribution. Further, faults that occur within the estimated Gaussian distribution may go undetected. In this study, we present a model-based trust estimation system that allows for concept drift or distributions that can change over time. The presented methodology uses data-driven models to estimate the value of the data produced by a sensor using the data produced by the other sensors in the network. We assume that an untrustworthy piece of data falls in the tails of the residual distribution, and we use this concept to assign a trust score. The method is evaluated on a smart home data set consisting of temperature, humidity, and energy sensors.
Cyclic V3‐loop‐related HIV‐1 conjugate vaccines Synthesis, conformation and immunological properties (1993)

Branched undecapeptides with sequences related to the virus glycoprotein V3 domain sequences of the MN and IIIB variants of HIV-1 were synthesized and cyclized with a peptide (amide) closure to cyclic decapeptides. Two-dimensional NMR studies allowed protons for the MN variant-related cycle (L-697,250) to be assigned. Molecular modelling with distance geometry methods permitted a conformation to be identified which showed good agreement with ROESY and 2D NMR study data. A molecular dynamics simulation showed that the highly conserved loop tip sequence (Gly-Pro-Gly-Arg) was in a conventional beta-turn less than 50% of the time. For evaluation of immunogenicity and antibody characterization studies, covalent carrier conjugates were prepared. 3-Maleimidopropionylation of the Nle amino group of the cyclic peptides gave an electrophilic tether which captured a thiol group from a thiolated carrier protein, OMPC (outer membrane protein complex of Neisseria meningitidis). Through the use of a novel co-conjugation procedure, soluble immunogen-carrier molecules were prepared which had suitable physical properties for use as a vaccine. These V3-loop-based vaccines could elicit neutralizing antibody, but not consistently in all animals. Characterization of sera showed that responses were broadly virus neutralizing.