gebhart/patrepeval huggingface dataset:
External diode-laser-array cavity with mode-selecting mirror (1993)

A new external optical cavity employing a mode-selecting mirror is used to tailor the amplitude and phase of the fundamental array mode and discriminate between higher-order modes. We explore the ability of this phase-coded mirror to select a particular mode and compare it with a conventional Talbot cavity. Diffraction-limited performance of the in-phase fundamental mode is shown.
Convective air, microwave, and combined drying of potato pre-treated by pulsed electric fields (2018)

The effects of pulsed electric field (PEF) treatment on drying of potato have been investigated. The convective air (CA) (T = 50 °C), microwave (MW), and combined (CA + MW or MW + CA) drying was applied. The drying curves, progression of temperature inside samples, microstructure, and capillary imbibition capacity of untreated (U) and PEF treated samples were compared. The PEF treatment noticeably affected the CA and MW drying characteristics and structure of dried samples. It reflected impact of electroporation on the heat and mass transfer processes during the different drying periods. The different progressions of temperatures inside U and PEF samples for the MW mode of drying were revealed. The highest and smallest rehydrations were observed for the U samples for individual CA and MW modes of drying, respectively. The observed behavior was explained accounting for the absence of starch gelatinization for the CA mode of drying and presence of it for the MW mode of drying.
A phase I trial of a modified, dose intensive FAMTX regimen (High dose 5‐fluorouracil + doxorubicin + high dose methotrexate + leucovorin) with oral uridine rescue (1996)

BACKGROUND Dose intensification of 5-fluorouracil (5-FU) is complicated by increased toxicity. 5-FU is a fluorine-substituted pyrimidine analog of uracil. In preclinical studies, administration of oral uridine (Ur) has been shown to allow for dose intensification of 5-FU with enhancement of its antitumor activity. Therefore, a Phase I trial was designed aimed at dose intensification of 5-FU as a component of a modified 5-FU-doxorubicin-methotrexate (FAMTX) regimen using oral Ur rescue. METHODS Methotrexate (MTX) was administered to all patients at a fixed dose of 1.5 g/m2. MTX was followed 24 hours later by escalating doses of 5-FU starting at 800 mg/m2 with leucovorin rescue. Cycles of 5-FU and MTX were repeated every 15 days. Every other cycle, patients received doxorubicin (“Adria cycles”) at a dose of 30 mg/m2. Oral Ur was administered at a dose of 8 gm/m2 every 6 hours for 12 doses. In the first phase of the study, patients received Ur only if they developed Grade 3 or 4 hematologic toxicity. In the second phase, all patients received Ur 24 hours after 5-FU on all cycles. RESULTS Without Ur rescue, the maximum tolerated dose (MTD) of 5-FU was 900 mg/m2 on the Adria cycles and 1.1 gm/m2 on the non-Adria cycles. With Ur, the MTD of 5-FU increased to 1.2 gm/m2 on the Adria cycles and to 1.6 gm/m2 on the non-Adria cycles. CONCLUSIONS In this modified FAMTX regimen, oral Ur administration allowed for dose-intensification of 5-FU, with a 33% increase in the MTD of 5-FU on the Adria cycles and a 45% increase in the MTD of 5-FU dose on the non-Adria cycles. Cancer 1997=6;78:1988-95.
Targeted sequencing of plasma cell-free DNA to predict response to PD1 inhibitors in advanced non-small cell lung cancer. (2019)

103 Background: Tumor mutational burden is an emerging biomarker of response to immune checkpoint inhibitors (ICI), whose clinical adoption is challenging, especially in liquid biopsies. We hypothesized that targeting limited but relevant genetic alterations in plasma cell-free DNA with next generation sequencing (NGS) along with early monitoring may represent a non-invasive approach to predict response to ICI. Methods: Plasma samples from responders (PFS &gt; 6 months) and non-responders (progressive disease at first evaluation) patients collected before nivolumab (second line) initiation and at 1 month were tested using tagged amplicon sequencing of hotspots and coding regions from 36 genes, blinded to clinical outcomes and tumor genotype. Molecular profile of ctDNA, and its early kinetics (1 month) were analyzed as potential early indicators of response. Results: 98 patients were analyzed, of which 86 (39 responders, 47 non-responders) were evaluable for response. Alterations in ctDNA were detectable in 67/86 baseline samples (78%). The detection of a targetable oncogenic driver (5 EGFR, 1 ALK) was associated with progressive disease on the first CT-scan The presence of a PTEN and/or STK11 mutations (b-PS(+)) was correlated with poor outcomes (median PFS 1.5 months vs. 8 months in b-PS(-)) patients, p = 0.0007), while the presence of transversion mutations in KRAS and/or TP53 (b-KP-Tv(+)) predicted good outcomes (median PFS 11 months vs. 2 months in b-KP-Tv(-) patients, p = 0.0088). Combining these results, patients with a low “immune score” (driver and/or b-PS(+) and/or b-KP-Tv(-)) derived poor outcomes (PFS 2 months), compared with patients with a high immune score (no driver, b-PS(-) and b-KP-Tv(+), PFS 14 months, p = 0.0001, HR 2.96). Studying early changes in 65 specimens, molecular response was correlated with clinical outcomes (14 months PFS in patients with early ctDNA decrease compared to 2 months in patients with increase, p &lt; 0.0001; HR 2.7). Using cut-off of 30% and 50% of plasma response increased the ability of ctDNA to predict response (HR 4 and 4.17, respectively). Conclusions: Targeted sequencing of plasma ctDNA and its early variations can predict response to anti-PD-1. Clinical trial information: NCT02827344.
Variable spatiotemporal resolution three‐dimensional dixon sequence for rapid dynamic contrast‐enhanced breast MRI (2014)

Purpose To investigate a new variable spatiotemporal resolution dynamic contrast‐enhanced (DCE) MRI method termed DIfferential Subsampling with Cartesian Ordering (DISCO), for imaging of breast cancer. Materials and Methods DISCO combines variable density, pseudorandom k ‐space segmentation and two‐point Dixon fat–water separation for high spatiotemporal resolution breast DCE MRI. During the contrast wash‐in phase, view sharing is used to achieve high temporal resolution. Forty patients referred for breast MRI were imaged, 26 using the proposed DISCO sequence and 14 using a conventional low‐spatial‐resolution dynamic sequence (VIBRANT‐FLEX) on a 3 Tesla scanner. DISCO dynamic images from 14 patients were compared with VIBRANT‐FLEX images from 14 other patients. The image quality assessed by radiologist image ranking in a blinded manner, and the temporal characteristics of the two sequences were compared. Results A spatial resolution of 1.1 × 1.1 × 1.2 mm 3 (160 slices, 28 cm field of view) was achieved with axial bilateral coverage in 120 s. Dynamic images with ∼9 s effective temporal resolution were generated during the 2‐min contrast wash‐in phase. The image quality of DISCO dynamic images ranked significantly higher than low spatial resolution VIBRANT‐FLEX images (19.5 versus 9.5, Mann‐Whitney U ‐test P = 0.00914), with no significant differences in the maximum slope of aortic enhancement. Conclusion DISCO is a promising variable‐spatiotemporal‐resolution imaging sequence for capturing the dynamics of rapidly enhancing tumors as well as structural features postcontrast. A near 1‐mm isotropic spatial resolution was achieved with postcontrast static phase images in 120 s and dynamic phase images acquired in 9 s per phase. J. Magn. Reson. Imaging 2014;40:1392–1399 . © 2013 Wiley Periodicals, Inc .
Supplementary Figure Legends, Tables 1 - 3 from Loss of Tuberous Sclerosis Complex 2 (TSC2) Is Frequent in Hepatocellular Carcinoma and Predicts Response to mTORC1 Inhibitor Everolimus (2023)

&lt;p&gt;Supplementary Table 1. Quantification of phospho-protein levels in Figure 1B. Supplementary Table 2. Everolimus IC50 and growth inhibition at 1uM in HCC cell lines. Supplementary Table 3. Quantification of phospho-protein levels in Figure 2A.&lt;/p&gt;
The Effect of an Exogenous Fibrin Clot on the Regeneration of the Triangular Fibrocartilage Complex: An In Vivo Experimental Study in Dogs (2000)

The effect of an exogenous fibrin clot on the regeneration of the triangular fibrocartilage complex (TFCC) was examined in a dog model. In 12 mature dogs, bilateral TFCC resection was performed. The resulting defect was packed with an exogenous fibrin clot (experimental) while the contralateral side was left empty (control). Tissue regeneration was evaluated grossly and histologically at 6, 12, and 26 weeks. At each time period, the regenerated tissue in the fibrin clot-filled defect appeared more mature and more congruent with the adjacent cartilaginous surfaces than did the control (empty) defect. At 26 weeks, the clot regenerated tissue had the histological appearance of a normal TFCC with a homogeneous fibrocartilaginous matrix, regularly oriented collagen fibers, and normal integration with the adjacent support structures of the joint. The results of this study indicate that an exogenous fibrin clot could be used to promote a fibrocartilaginous repair tissue for a resected TFCC. Such therapy could be used in the arthroscopic treatment of TFCC injury and resection in an effort to improve postoperative outcome.
Mesenteric lymph nodes are critical for the induction of high-dose oral tolerance in the absence of Peyer's patches (2002)

We have previously demonstrated the loss of oral tolerance (OT) in lymphotoxinalpha-/- (LTalpha-/-) and TNFalpha / lymphotoxinalpha deficient (TNFalpha / LTalpha-/-) mice which have defective Peyer's patches (PP) and lymph node (LN) development. We have now studied OT in BALB / c mice with differential defects of the gut-associated lymphoid tissue (GALT) caused by inhibition of LTbetaR signaling during fetal development. Treatment of pregnant mice with LTbetaR-IgG (LTbetaRIgG) and TNFR I55-IgG (TNFR55IgG) abrogates the formation of PP (LTbetaRIgG) or of PP and mesenteric LN (MLN) (LTbetaRIgG / TNFRIgG) without genetically deleting the respective cytokine pathways. OT was readily induced in mice without PP but retaining MLN (PP null / LN +). In contrast, OTcould not be induced in mice lacking both MLN and PP (PP null / MLN null) as shown by the inability of these mice to suppress IFN-gamma secretion or DTH reactions. We next assessed OT in 129 x B6 LTalpha-/- mice with and without MLN. Timed treatment of pregnant LTalpha-/- mice with an agonist anti-LTbetaR mAb induces formation of MLN but not of PP in LTalpha-/- mice. LN + LTalpha-/- mice developed OT while LN LTalpha-/- mice were resistant to OT induction. Taken collectively, the data show that in the presence of MLN PP are not required for OT induction and that the presence of MLN is sufficient for OT induction in the LTalpha-/- model.
An LCL-N Compensated Strongly-Coupled Wireless Power Transfer System for High-Power Applications (2019)

An LCL-none (LCL-N) topology is proposed in this paper for high-power strongly-coupled wireless charging systems. The receiver-side compensation is eliminated to achieve a compact and lightweight receiver. The efficiency is still high due to the strongly-coupled characteristic. The phase difference between the transmitter and receiver currents is larger than 90°, leading to the magnetic flux cancelation in the ferrites. Thus, the required ferrite thickness of the LCL-N topology is smaller than the fully-compensated topologies. Therefore, a compact, lightweight, and low-cost receiver is achieved. The model of the LCL-N topology is built and the output power and the efficiency are analyzed. A full-scaled system of 100 kW is designed and simulated. A downscaled 1 kW system is implemented. The simulations and experiments have verified the effectiveness of the analysis.
Practical Energy-Aware Link Adaptation for MIMO-OFDM Systems (2014)

In this paper, we present a practical link adaptation algorithm for MIMO-OFDM systems. The proposed solution is based on sounding the channel periodically and choosing the optimal mode that will maximize the throughput or energy efficiency (EE) while satisfying the application's quality of service (QoS) requirements. In addition, we address practical problems such as the computational complexity of the algorithm and determination of sounding period by novel closed form solutions and iterative algorithms. Realistic link level simulations confirm that the proposed solution achieves significant improvement over existing link adaptation algorithms when the aim is to maximize the throughput, and provides orders of magnitude gain in energy efficiency compared to poorly chosen fixed modes when used for energy efficiency maximization purposes. The resulting algorithms are implemented on a real time MIMO-OFDM testbed, and we report on the experimental results.
CubeSat Communications: Recent Advances and Future Challenges (2019)

Given the increasing number of space-related applications, research in the emerging space industry is becoming more and more attractive. One compelling area of current space research is the design of miniaturized satellites, known as CubeSats, which are enticing because of their numerous applications and low design-and-deployment cost. The new paradigm of connected space through CubeSats makes possible a wide range of applications, such as Earth remote sensing, space exploration, and rural connectivity. CubeSats further provide a complementary connectivity solution to the pervasive Internet of Things (IoT) networks, leading to a globally connected cyber-physical system. This paper presents a holistic overview of various aspects of CubeSat missions and provides a thorough review of the topic from both academic and industrial perspectives. We further present recent advances in the area of CubeSat communications, with an emphasis on constellation-and-coverage issues, channel modeling, modulation and coding, and networking. Finally, we identify several future research directions for CubeSat communications, including Internet of space things, low-power long-range networks, and machine learning for CubeSat resource allocation.
Touching and Interacting with Inaccessible Cultural Heritage (2015)

The sense of touch provides a particular access to our environment, enabling a tangible relation with it. In the particular case of cultural heritage, touching the past, apart from being a universal dream, can provide essential information to analyze, understand, or restore artifacts. However, archaeological objects cannot always offer tangible access, either because they have been destroyed or are too damaged, or because they are part of a larger assembly. In other cases, it is the context of use that has become inaccessible, as it is related to an outdated activity. We propose a workflow based on a combination of computed tomography, 3D images, and 3D printing to provide concrete access to cultural heritage, and we illustrate this workflow in different contexts of inaccessibility. These technologies are already used in cultural heritage, but seldom combined, and are most often employed for exceptional artifacts. We propose to combine these technologies in case studies corresponding to relevant archaeological situations.
Structural control of self-healing silica–poly(tetrahydropyran)–poly(ε-caprolactone) hybrids (2021)

In some biomaterial applications, the device needs to resist cyclic loading. Recently, self-healing hybrid systems with interpenetrating network of organic and inorganic components have been discovered. In this work, we clarify the structure-mechanical property relations in a new series of silica-poly(tetrahydropyran)-poly(ε-caprolactone) (SiO2-PTHP-PCL) materials, which were prepared through a three-step synthesis, including one-pot cationic ring-opening polymerization, sol-gel reaction, and polymer-silica cross condensation. We applied THP as the main constituent of the organic phase and achieved successful polymerization under mild conditions, while the hybrid structures were controlled by the degree of silica-crosslinking and the organic/inorganic ratio. The thermal stabilities, densities, Young's modulus as well as hardness could also be regulated through such control. Notably, we find that the hybrid materials with organic polymer content above 73% are able to self-heal induced damages, including under body temperature conditions and the mechanical properties of the self-healed material are similar to those of the fresh samples. We ascribe this primarily to the reversible intermolecular interactions and hydrogen bonding among the polymer chains. Finally, we discover that the PTHP-SiO2 networks are stable in a simulated bio-environment although PCL underwent biodegradation. The present structural control approach could lead to the design of tailored functional hybrid materials, with potential applications within areas such as soft robotics and bone regeneration.
Automated Construction of High-Density Comparative Maps Between Rat, Human, and Mouse (2001)

Animal models have been used primarily as surrogates for humans, having similar disease-based phenotypes. Genomic organization also tends to be conserved between species, leading to the generation of comparative genome maps. The emergence of radiation hybrid (RH) maps, coupled with the large numbers of available Expressed Sequence Tags (ESTs), has revolutionized the way comparative maps can be built. We used publicly available rat, mouse, and human data to identify genes and ESTs with interspecies sequence identity (homology), identified their UniGene relationships, and incorporated their RH map positions to build integrated comparative maps with >2100 homologous UniGenes mapped in more than one species (approximately 6% of all mammalian genes). The generation of these maps is iterative and labor intensive; therefore, we developed a series of computer tools (not described here) based on our algorithm that identifies anchors between species and produces printable and on-line clickable comparative maps that link to a wide variety of useful tools and databases. The maps were constructed using sequence-based comparisons, thus creating "hooks" for further sequence-based annotation of human, mouse, and rat sequences. Currently, this map enables investigators to link the physiology of the rat with the genetics of the mouse and the clinical significance of the human.
The Catalytic Properties and Behavior of Carbon Deposition in CO2 Reforming of Methane on NiO-MgO Solid Solution Catalyst under High Pressure. (1999)

常圧条件下でのメタンの炭酸ガスリフォーミング反応において, 炭素析出することなく, 長時間安定した触媒活性を示すNiO-MgO (Ni0.03Mg0.97O) 固溶体触媒上の高圧 (～2.0MPa) 条件下での反応特性と炭素析出挙動について検討した。参照触媒として市販のスチームリフォーミング用触媒についても研究を行った。市販の触媒では大量に炭素析出が起こり, 主に反応器入口で進行したことから, その炭素は主にメタンに由来することが示唆された。Ni0.03Mg0.97O固溶体触媒では, 炭素析出量はそれに比較して非常に少なく, 炭素析出量は入口に比べて出口に多く析出した。メタンに由来する炭素析出が大きく抑制され, COに由来するものが主になったと考えられる。
Role of high intensity focused ultrasound induced cavitation on platelet aggregation (2001)

Our previous studies showed that high-intensity focused ultrasound (HIFU) is capable of producing ‘‘primary acoustic hemostasis’’ in the form of platelet activation, aggregation, and adhesion to a collagen-coated surface. In current studies, 1.1 MHz CW HIFU was used to investigate the role of cavitation as a mechanism for platelet aggregation in samples of platelet rich plasma. A 5 MHz passive cavitation detector was used to monitor cavitation activity, and laser aggregometry was used to measure platelet aggregation. Using spatial average intensities from 0 to 4000 W/cm2, the effects of HIFU induced cavitation on platelet aggregation were investigated by enhancing cavitation activity through use of ultrasound contrast agents, and by limiting cavitation activity through use of an overpressure system. Our results show that increased cavitation activity lowers the intensity threshold to produce platelet aggregation, and decreased cavitation activity in the overpressure system raises the intensity threshold for platelet aggregation. [Research supported by DARPA.]
ChemInform Abstract: Realumination of Dealuminated HZSM‐5 Zeolites by Acid Treatment. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Low-Frequency EPR of the Copper in Particulate Methane Monooxygenase from Methylomicrobium albus BG8 (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTLow-Frequency EPR of the Copper in Particulate Methane Monooxygenase from Methylomicrobium albus BG8Hua Yuan, Mary Lynne Perille Collins, and William E. AntholineView Author Information Biophysics Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 Department of Biological Sciences and §Center for Great Lakes Studies, The University of WisconsinMilwaukee, Milwaukee, Wisconsin 53201 Cite this: J. Am. Chem. Soc. 1997, 119, 21, 5073–5074Publication Date (Web):May 28, 1997Publication History Received21 January 1997Published online28 May 1997Published inissue 1 May 1997https://doi.org/10.1021/ja9701669Copyright © 1997 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views285Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (79 KB) Get e-AlertsSUBJECTS:Copper,Electron paramagnetic resonance spectroscopy,Free radicals,Nitrogen,Peptides and proteins Get e-Alerts
Extracellular vesicle and particle isolation from human and murine cell lines, tissues, and bodily fluids (2020)

We developed a modified protocol, based on differential ultracentrifugation (dUC), to isolate extracellular vesicles and particles (specifically exomeres) (EVPs) from various human and murine sources, including cell lines, surgically resected tumors and adjacent tissues, and bodily fluids, such as blood, lymphatic fluid, and bile. The diversity of these samples requires robust and highly reproducible protocols and refined isolation technology, such as asymmetric-flow field-flow fractionation (AF4). Our isolation protocol allows for preparation of EVPs for various downstream applications, including proteomic profiling. For complete details on the use and execution of this protocol, please refer to Hoshino et al. (2020).