gebhart/patrepeval huggingface dataset:
Algorithmic problems of group theory, their complexity, and applications to cryptography : AMS Special Sessions Algorithmic Problems of Group Theory and Their Complexity, January 9-10, 2013, San Diego, California : Algorithmic Problems of Group Theory and Applications to Information Security, April 6-7, 2013, Boston College, Chestnut Hill, Massachusetts (2015)

Secret sharing using non-commutative groups and the shortlex order by B. Cavallo and D. Kahrobaei An algorithm that decides conjugacy in a certain generalized free product by A. E. Clement Classification of automorphic conjugacy classes in the free group on two generators by B. Cooper and E. Rowland On elementary free groups by B. Fine, A. Gaglione, G. Rosenberger, and D. Spellman An application of a localized version of an axiom of Ian Chiswell by A. M. Gaglione, S. Lipschutz, and D. Spellman A note on Stallings' pregroups by A. M. Gaglione, S. Lipschutz, and D. Spellman A CCA secure cryptosystem using matrices over group rings by D. Kahrobaei, C. Koupparis, and V. Shpilrain The MOR cryptosystem and finite $p$-groups by A. Mahalanobis A group theoretical ElGamal cryptosystem based on a semidirect product of groups and a proposal for a signature protocol by A. I. S. Moldenhauer On some algorithmic properties of finite state automorphisms of rooted trees by B. Steinberg
Soft Electronics Manufacturing Using Microcontact Printing (2019)

Abstract This work describes a microcontact printing (µCP) process for reproducible manufacturing of liquid gallium alloy–based soft and stretchable electronics. One of the leading approaches to create soft and stretchable electronics involves embedding liquid metals (LM) into an elastomer matrix. Although the advantages of liquid metal–based electronics have been well established, their mainstream adoption and commercialization necessitates development of precise and scalable manufacturing methods. To address this need, a scalable µCP process is presented that uses surface‐functionalized, reusable rigid, or deformable stamps to transfer eutectic gallium–indium (EGaIn) patterns onto elastomer substrates. A novel approach is developed to create the surface‐functionalized stamps, enabling selective transfer of LM to desired locations on a substrate without residues or electrical shorts. To address the critical needs of precise and reproducible positioning, alignment, and stamping force application, a high‐precision automated µCP system is designed. After describing the approach, the precision of stamps is evaluated and EGaIn features (as small as 15 µm line width), as well as electrical functionality of printed circuits with and without deformation, are fabricated. The presented process addresses many of the limitations associated with the alternative fabrication processes, and thus provides an effective approach for scalable fabrication of LM‐based soft and stretchable microelectronics.
PPARgamma inhibits hepatocellular carcinoma metastases in vitro and in mice (2012)

Peroxisome proliferator-activated receptor-gamma exerts an inhibitory effect on the invasive and metastatic potential of HCC in vitro and in vivo, and is thus, a target for the prevention and treatment of HCC metastases.
Autonomous Demand Smoothing for Efficiency Improvements on Military Forward Operating Bases (2020)

This paper presents autonomous control algorithms for electrical loads like HVAC (Heating, Ventilation, and Air Conditioning) systems. These algorithms permit a load to become “aware” of the operation of neighboring loads using nonintrusive measurements of the utility voltage. Analogous to the way a good driver is aware of neighboring cars while driving, loads can use this information to become “self-driving.” For HVAC systems, this permits maintaining occupant comfort while simultaneously reducing bulk peak electrical demand. Electric energy consumption for each load occurs on a schedule, interleaved with the operation of neighboring units. The algorithms are demonstrated here using simulation models developed from nonintrusive load monitoring (NILM) data collected from the microgrid of a US Army forward operating base (FOB). The general approach, however, can be applied in many other venues, e.g., to minimize peak load on distribution transformers in a section of the conventional utility.
Corpus-based techniques in the AT&t nextgen synthesis system (2000)

The AT&T text-to-speech (TTS) synthesis system has been used as a framework for experimenting with a perceptuallyguided data-driven approach t o s p e e c h s y n thesis, with primary focus on data-driven elements in the \back end".Statistical training techniques applied to a large corpus are used to make decisions about predicted speech e v ents and selected speech i n ventory units.Our recent a d v ances in automatic phonetic and prosodic labeling and a new faster harmonic plus noise model (HNM) and unit preselection implementations have signi cantly improved TTS quality and speeded up both development time and runtime.
De novo design of a β -helix tau protein scaffold: An oligomer-selective vaccine immunogen candidate for Alzheimer’s disease (2023)

Abstract Tau pathology is associated with many neurodegenetive disorders, including Alzheimer’s disease (AD), where the spatio-temporal pattern of tau neurofibrillary tangles strongly correlates with disease progression, which motivates therapeutics selective for misfolded tau. Here, we introduce a new avidity-enhanced, multi-epitope approach for protein misfolding immunogen design, which is predicted to mimic the conformational state of an exposed epitope in toxic tau oligomers. A predicted oligomer-selective tau epitope 343 KLDFK 347 was scaffolded by designing a β -helix structure that incorporated multiple instances of the 16-residue tau fragment 339 VKSEKLDFKDRVQSKI 354 . Largescale conformational ensemble analyses involving Jensen-Shannon Divergence and the embedding depth 𝒟 showed that the multi-epitope scaffolding approach, employed in designing the β -helix scaffold, was predicted to better discriminate toxic tau oligomers than other “monovalent” strategies utilizing a single instance of an epitope for vaccine immunogen design. Using Rosetta, 10,000 sequences were designed and screened for the linker portions of the β -helix scaffold, along with a C-terminal stabilizing α -helix that interacts with the linkers, to optimize the folded structure and stability of the scaffold. Structures were ranked by energy, and the lowest 1% (82 unique sequences) were verified using AlphaFold. Several selection criteria involving AlphaFold are implemented to obtain a lead designed sequence. The structure was further predicted to have free energetic stability by using Hamiltonian replica exchange molecular dynamics (MD) simulations. The synthesized β -helix scaffold showed direct binding in surface plasmon resonance (SPR) experiments to several antibodies that were raised to the structured epitope using a designed cyclic peptide. Moreover the strength of binding of these antibodies to in vitro tau oligomers correlated with the strength of binding to the β -helix construct, suggesting that the construct presents an oligomer-like conformation and may thus constitute an effective oligomer-selective immunogen.
Inhibitors of Bacterial Multidrug Efflux Pumps Potentiate Antimicrobial Photoinactivation (2008)

Antimicrobial photodynamic inactivation (APDI) combines a nontoxic photoactivatable dye or photosensitizer (PS) with harmless visible light to generate singlet oxygen and reactive oxygen species that kill microbial cells. Cationic phenothiazinium dyes, such as toluidine blue O (TBO), are the only PS used clinically for APDI, and we recently reported that this class of PS are substrates of multidrug efflux pumps in both gram-positive and gram-negative bacteria. We now report that APDI can be significantly potentiated by combining the PS with an efflux pump inhibitor (EPI). Killing of Staphylococcus aureus mediated by TBO and red light is greatly increased by coincubation with known inhibitors of the major facilitator pump (NorA): the diphenyl urea INF271, reserpine, 5'-methoxyhydnocarpin, and the polyacylated neohesperidoside, ADH7. The potentiation effect is greatest in the case of S. aureus mutants that overexpress NorA and least in NorA null cells. Addition of the EPI before TBO has a bigger effect than addition of the EPI after TBO. Cellular uptake of TBO is increased by EPI. EPI increased photodynamic inactivation killing mediated by other phenothiazinium dyes, such as methylene blue and dimethylmethylene blue, but not that mediated by nonphenothiazinium PS, such as Rose Bengal and benzoporphyrin derivative. Killing of Pseudomonas aeruginosa mediated by TBO and light was also potentiated by the resistance nodulation division pump (MexAB-OprM) inhibitor phenylalanine-arginine beta-naphthylamide but to a lesser extent than for S. aureus. These data suggest that EPI could be used in combination with phenothiazinium salts and light to enhance their antimicrobial effect against localized infections.
Preparation of Primary Thioamides from Nitriles Using Sodium Hydrogen Sulfide and Diethylamine Hydrochloride. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Design for metrology for freeform optics manufacturing (2019)

Freeform optical surfaces offer significant design opportunities but pose new challenges in metrology and manufacturing. Evolution in optics manufacturing processes have changed the surface spatial frequencies that must be measured. Optical surface definition is expected to be with respect to fiducials and datums which must be realizable at all stages of manufacture; uncertainty in that realization becomes important in some cases. Concurrent engineering is required, but appropriate data has not been collated for use by optical designers. One approach to providing such data is described.
Formulation and development of taste masked fast-disintegrating tablets (FDTs) of Chlorpheniramine maleate using ion-exchange resins (2011)

The Effective taste masking can be obtained from DRC that can be formulated as FDTs for better patient compliance.
The Immune and Inflammatory Basis of Acquired Pediatric Cardiac Disease (2021)

Children with acquired heart disease face significant health challenges, including a lifetime of strict medical management, multiple cardiac surgeries, and a high mortality risk. Though the presentation of these conditions is diverse, a unifying factor is the role of immune and inflammatory responses in their development and/or progression. For example, infectious agents have been linked to pediatric cardiovascular disease, leading to a large health burden that disproportionately affects low-income areas. Other implicated mechanisms include antibody targeting of cardiac proteins, infection of cardiac cells, and inflammation-mediated damage to cardiac structures. These changes can alter blood flow patterns, change extracellular matrix composition, and induce cardiac remodeling. Therefore, understanding the relationship between the immune system and cardiovascular disease can inform targeted diagnostic and treatment approaches. In this review, we discuss the current understanding of pediatric immune-associated cardiac diseases, challenges in the field, and areas of research with potential for clinical benefit.
Entwicklung und Etablierung einer robotischen Pankreatogastrostomie (2019)

Im Rahmen der robotischen Pankreatoduodenektomie hat sich die Pankreatikojejunostomie nach L. H. Blumgart international durchgesetzt.
Building Open Learning Environment for Software Engineering Students (2010)

The chapter discusses principles of open education and possibilities of implementing these principles for software engineering education on the base of open source software development projects. A framework of practical courses for software engineering students built on these ideas is presented. Experience of building courses on the base of this framework is discussed on the example of “Software Engineering” course provided to students of the System Programming departments of the two Russian top-ranked universities, Moscow State University and Moscow Institute of Physics and Technology.
ChemInform Abstract: Parallel Synthesis and Evaluation of N‐(1‐Phenylethyl)‐5‐phenyl‐imidazole‐2‐amines as Na+/K+ ATPase Inhibitors. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
074 S-Nitrosoglutathione Reductase (GSNOR) Protects against Western Diet Induced Reactive Oxygen Species Production and Erectile Dysfunction (2016)

Binding of nitric oxide (NO) to a cysteine thiol is termed S-nitrosylation, which is emerging as an important means of NO-mediated signal transduction independent of stimulation of soluble guanylate cyclase. However, the impact of S-nitrosylation on erectile function remains unclear. S-nitrosylation is a redox sensitive post-translational modification, which is thought to be promoted by reactive oxygen species (ROS). Protein S-nitrosylation levels are regulated in part by S-nitrosoglutatione reductase (GSNOR), which acts to de-nitrosylate protein thiols. The objectives of this study were to determine the role of GSNOR on maintenance of redox balance and erectile function in response to a Western diet (WD) high in fat and sugar. Young male wild type (WT; n = 94) and GSNOR-/- (n = 92) mice were fed either a control diet or a WD ad libitum for 3, 6, 9, or 12 weeks. Following the dietary intervention, erectile function was assessed by measuring intracavernosal pressure (ICP) and mean arterial pressure (MAP) during cavernous nerve stimulation. In separate mice, in vivo ROS production was measured in the penis utilizing a novel microdialysis approach. Microdialysis probes were inserted into the penis of anesthetized mice and perfused with saline containing 100 uM Amplex Ultrared, 1 U/ml horseradish peroxidase, and 10 U/ml superoxide dismutase. ROS convert the reagents to a fluorescent byproduct resorufin, which was measured in the outflowing dialysate.
Programming, Problem Solving, and Self-Awareness (2016)

More people are learning to code than ever, but most learning opportunities do not explicitly teach the problem solving skills necessary to succeed at open-ended programming problems. In this paper, we present a new approach to impart these skills, consisting of: 1) explicit instruction on programming problem solving, which frames coding as a process of translating mental representations of problems and solutions into source code, 2) a method of visualizing and monitoring progression through six problem solving stages, 3) explicit, on-demand prompts for learners to reflect on their strategies when seeking help from instructors, and 4) context-sensitive help embedded in a code editor that reinforces the problem solving instruction. We experimentally evaluated the effects of our intervention across two 2-week web development summer camps with 48 high school students, finding that the intervention increased productivity, independence, programming self-efficacy, metacognitive awareness, and growth mindset. We discuss the implications of these results on learning technologies and classroom instruction.
Methane hydroxylation using light energy by the combination of thylakoid and methane monooxygenase (2014)

We construct a photoinduced methane hydroxylation system by the combination of thylakoid and methane monooxygenase from <italic>Methylosinus trichosporium</italic> OB3b.
Design of reconfigurable electromagnetic bandgap surfaces as artificial magnetic conducting ground planes and absorbers (2006)

The research presented in this paper adapts the reconfigurable FSS technology to EBG AMC surface design, which utilizes a periodic array of fixed metallic cross-dipole elements connected by ideal switches. This structure can be reconfigured to achieve the AMC condition for various resonant frequencies. The introduction of loss into the FSS screen also allows the design of reconfigurable EBG absorbers
Overexpression of Merlin in B16F10 mouse melanoma cells reduces their metastatic activity: Role of the cell surface heparan sulfate glycosaminoglycans (2008)

Merlin, the protein product of the neurofibromatosis type 2 gene (NF2) acts as a tumor suppressor in mice and humans. In this study, melanoma B16F10 cells were engineered to overexpress the NF2 gene by establishing stable transductants. A cell line overexpressing Merlin (B16F10-M) was generated. When compared to the parental cells, the B16F10-M cells demonstrated differences in their cell surface organization. The overexpressing strain changed its ability to grow in soft agar as well as its cell motility properties. B16F10-M cells were then examined in the in vivo mouse melanoma tumor growth and tumor metastasis models. While tumor growth was marginally affected, the presence of increased Merlin severely reduced the metastastatic ability of the cells. When isolated using specific enzymes with distinct substrate specificity, the cell surface heparan sulfate glycosaminoglycans (HSGAGs) from the overexpressing B16F10-M cells, inhibited the metastatic properties of the parental B16F10 cells. The results obtained provide a causal link between the reorganization/changes to the cell surface HSGAGs by the overexpression of Merlin and the inhibition of the metastatic activity of the mouse melanoma B16F10 cells in vivo.
Fungal allergens from important allergenic fungi imperfecti. (1997)

Occurrence of several fungal species in the environment seems to be related to hypersensitivity disorders in humans. Fungal allergen studies reported in the literature are reviewed regarding to Aspergillus, Alternaria, Penicillium and Cladosporium genera. In this paper, we study by means of in vivo (Skin Prick Test) and in vitro (RAST and immunoblotting) the classical question of the best source of allergenic material using a population of asthmatic patients sensitized to different mould genera. In Alternaria alternata, RAST values are considerably higher in metabolic extracts (culture filtrate) than in somatic ones (myceliar). In Alternaria alternata and Penicillium chrysogenum, low molecular weight allergens (< 30 kDa) show higher IgE-binding activity in culture filtrate extracts. In Aspergillus fumigatus we find some relevant allergens in the mycellium. Different fractions have also been used in skin tests and culture filtrate extracts showing higher potency than myceliar ones, what is in agreement with the former results. We found in Penicillium chrysogenum that the 67 kDa allergen, similar to what described by Shen et al (1991), showed inespecific binding to anti-IgE conjugate used in the development of the immunoblotting technique. Whether or not this component could be a major allergen is discussed. We discuss about the importance of the biology of fungi in the sensitization and development of mould allergy.
Developmental Enhancement of Adenylate Kinase-AMPK Metabolic Signaling Axis Supports Stem Cell Cardiac Differentiation (2011)

Developmental deployment and upregulation of the adenylate kinase/AMPK tandem provides a nucleocytosolic energetic and metabolic signaling vector integral to execution of stem cell cardiac differentiation. Targeted redistribution of the adenylate kinase-AMPK circuit associated with cell cycle and asymmetric cell division uncovers a regulator for cardiogenesis and heart tissue regeneration.
Cumulative Phase Delay Imaging - a new contrast enhanced imaging modality (2015)

In chronic human schistosomiasis mansoni, the entire hepatic lobule is involved. The hepatovascular barrier is modified and shows hepatic sinusoids with hypertrophy and stratification of endothelium, basement membrane-like deposits, perisinusoidal fibrosis, diminution of hepatocellular microvilli and hepatocellular clasmatosis into the sinusoidal circulation. This transformation of an open circulation to a partly closed one may decrease the blood hepatocyte exchanges in schistosomiasis mansoni.
Mist chemical vapor deposition study of 20 and 100 nm thick undoped ferroelectric hafnium oxide films on n + -Si(100) substrates (2019)

Abstract This study effectively synthesized ferroelectric undoped ferroelectric-phase hafnium oxide (HfO 2 ) thin films on n + -Si(100) substrates without the need of any post-annealing for crystallization using mist chemical vapor deposition (CVD) techniques. Metal-ferroelectric highly doped n + -Si stacked capacitors exhibited ferroelectric polarization–electric field hysteresis at 1 kHz owing to the ferroelectric-phase HfO 2 with remnant polarization and coercive field values of approximately 7 μ C cm −2 and 1.4 MV cm −1 , respectively. The resultant endurance cycle reached 1 × 10 9 after imposing fatigue pulses of 3 MV cm −1 , which is an excellent value reported so far. These ferroelectric properties were related to the surface morphology and density of the films, compared to the post-annealed ones. A clear microcrystalline structure in the as-deposited films suggested the formation of intermediate chemical compounds containing carbon. On the contrary, the ferroelectricity was lost by post-anneal enhancing crystallization, especially for paraelectric monoclinic phase. Finally, we expect that the mist CVD HfO 2 films will be promising in developing a key technology for Si-based ferroelectric LSIs.
In the Wild Human Pose Estimation Using Explicit 2D Features and\n Intermediate 3D Representations (2019)

Convolutional Neural Network based approaches for monocular 3D human pose\nestimation usually require a large amount of training images with 3D pose\nannotations. While it is feasible to provide 2D joint annotations for large\ncorpora of in-the-wild images with humans, providing accurate 3D annotations to\nsuch in-the-wild corpora is hardly feasible in practice. Most existing 3D\nlabelled data sets are either synthetically created or feature in-studio\nimages. 3D pose estimation algorithms trained on such data often have limited\nability to generalize to real world scene diversity. We therefore propose a new\ndeep learning based method for monocular 3D human pose estimation that shows\nhigh accuracy and generalizes better to in-the-wild scenes. It has a network\narchitecture that comprises a new disentangled hidden space encoding of\nexplicit 2D and 3D features, and uses supervision by a new learned projection\nmodel from predicted 3D pose. Our algorithm can be jointly trained on image\ndata with 3D labels and image data with only 2D labels. It achieves\nstate-of-the-art accuracy on challenging in-the-wild data.\n