gebhart/patrepeval huggingface dataset:
Roles of the AMP‐activated and cyclic‐AMP‐dependent protein kinases in the adrenaline‐induced inactivation of acetyl‐CoA carboxylase in rat adipocytes (1990)

1. In isolated rat adipocytes, acetyl-CoA carboxylase is inactivated by treatment of the cells with adrenaline or the beta-agonist isoproterenol, but not by the alpha-agonist phenylephrine. The inactivation is stable during purification in the presence of protein phosphatase inhibitors, and is associated with a 30-40% increase in the labelling of enzyme isolated from 32P-labelled cells. 2. Increased phosphorylation occurs within peptide T1, which was identified by sequencing to be the peptide Ser-Ser77-Met-Ser79-Gly-Leu-His-Leu-Val-Lys, containing Ser-77 (phosphorylated by cyclic-AMP-dependent protein kinase) and Ser-79 (phosphorylated by the AMP-activated protein kinase). Analysis of the release of radioactivity as free phosphate during Edman degradation of peptide T1 revealed that all of the phosphate was in Ser-79 in both basal and hormone- or agonist-stimulated cells. Treatment of adipocytes with various agents which activate cyclic-AMP-dependent protein kinase by receptor-independent mechanisms (forskolin, cyclic AMP analogues, isobutylmethylxanthine) also produced inactivation of acetyl-CoA carboxylase and increased phosphorylation at Ser-79. 3. The (Rp)-[thio]phosphate analogue of cyclic AMP, which is an antagonist of binding of cyclic AMP to the regulatory subunit of cyclic-AMP-dependent protein kinase, opposes the effect of adrenaline on phosphorylation and inactivation of acetyl-CoA carboxylase. Together with the effects of isobutylmethylxanthine and the stimulatory cyclic AMP analogues, this strongly indicates that cyclic-AMP-dependent protein kinase is an essential component of the signal transduction pathway, although clearly it does not directly phosphorylate acetyl-CoA carboxylase. 4. As shown by okadaic acid inhibition, greater than 95% of the acetyl-CoA carboxylase phosphatase activity in extracts of rat adipocytes or liver is accounted for by protein phosphatase-2A, with less than 5% attributable to protein phosphatase-1. Inhibition of protein phosphatase-1 via phosphorylation of inhibitor-1 is therefore unlikely to be the mechanism by which cyclic-AMP-dependent protein kinase indirectly increases phosphorylation of acetyl-CoA carboxylase. Various other potential mechanisms are discussed.
Development of Graded Composite Electrodes for the SOFC (1999)

The simultaneous increase of electrochemical activity (i.e fineness) and thermal stability of SOFC-electrodes is possible using eutectic microstructures. On the basis of a lamellar NiO-YSZ eutectic a microwave melting process was developed which allows crystallization in a large temperature gradient. The microstructures obtained by melting the electrodes directly onto the top of a YSZ substrate (electrolyte) consist of partially aligned lamellae perpendicular to the surface of the substrate. The thickness of the alternating NiO-YSZ lamellae is graded over the thickness of the electrode, i.e it increases with increasing distance from the substrate. In terms of functionality this means an inverse gradient of electrochemical active three phase boundaries (gas-Ni-YSZ) after reduction of NiO to Ni. During the reduction process the microstructural gradient of lamellae thickness is converted into a functional gradient of electrochemical active sites. The models taken into account show that this functionally graded microstructure should lower the overpotentials of SOFC-devices. The paper concentrates on modelling and experimental details for the preparation of partially aligned eutectic lamellae with a graded interlamellar spacing.
Magnetic transitions in double perovskiteSr2FeRe1−xSbxO6(0⩽x⩽0.9) (2006)

The double perovskites ${\mathrm{Sr}}_{2}\mathrm{Fe}M{\mathrm{O}}_{6}$ $(M=\mathrm{Re},\mathrm{Mo})$ belong to the important class of half-metallic magnetic materials. In this study we explore the effect of replacing the electronic $5d$ buffer element Re with variable valency by the main group element Sb with fixed valency. X-ray diffraction reveals ${\mathrm{Sr}}_{2}{\mathrm{FeRe}}_{1\ensuremath{-}x}{\mathrm{Sb}}_{x}{\mathrm{O}}_{6}$ $(0&lt;x&lt;0.9)$ to crystallize without antisite disorder in the tetragonally distorted perovskite structure (space group $I4∕mmm$). The ferrimagnetic behavior of the parent compound ${\mathrm{Sr}}_{2}{\mathrm{FeReO}}_{6}$ changes to antiferromagnetic upon Sb substitution as was determined by magnetic susceptibility measurements. Samples up to a doping level of 0.3 are ferrimagnetic, while Sb contents higher than 0.6 result in an overall antiferromagnetic behavior. $^{57}\mathrm{Fe}$ and $^{121}\mathrm{Sb}$ M\"ossbauer spectroscopy specifies the valence state of Sb to be $+5$ within the whole range of substitution whereas the Fe valence state changes from $+2.7$ for the parent compound to $+2.9$ for ${\mathrm{Sr}}_{2}{\mathrm{FeRe}}_{0.1}{\mathrm{Sb}}_{0.9}{\mathrm{O}}_{6}$. Accordingly, Fe adopts the role of an electronic buffer element from Re upon heavy Sb doping. Additionally, $^{57}\mathrm{Fe}$ M\"ossbauer results show a coexistence of ferri- and antiferromagnetic clusters within the same perovskite-type crystal structure in the Sb substitution range $0.3&lt;x&lt;0.8$, whereas ${\mathrm{Sr}}_{2}{\mathrm{FeReO}}_{6}$ and ${\mathrm{Sr}}_{2}{\mathrm{FeRe}}_{0.9}{\mathrm{Sb}}_{0.1}{\mathrm{O}}_{6}$ are ``purely'' ferrimagnetic and ${\mathrm{Sr}}_{2}{\mathrm{FeRe}}_{0.1}{\mathrm{Sb}}_{0.9}{\mathrm{O}}_{6}$ contains antiferromagnetically ordered Fe sites only. Consequently, a replacement of the Re atoms by a nonmagnetic main group element such as Sb blocks the superexchange pathways $\text{\ensuremath{-}}\mathrm{Fe}\text{\ensuremath{-}}\mathrm{O}\text{\ensuremath{-}}\mathrm{Re}(\mathrm{Sb})\text{\ensuremath{-}}\mathrm{O}\text{\ensuremath{-}}\mathrm{Fe}\text{\ensuremath{-}}$ along the crystallographic axis of the perovskite unit cell and destroys the itinerant magnetism of the parent compound.
Coupled dynamics of flexible cables and rigid end-effector for a cable suspended robot (2006)

An important application of cable-suspended robots is in long-reach manipulation tasks. The usual assumption of rigid cables is not valid in these situations. The flexibility of cables needs to be included during modeling of residual motion of the manipulator after a gross motion has been made. In this paper, we assume that a gross motion has already been made that brings the end-effector to its desired position. Vibrations still persist due to flexibility in cables about this desired configuration. The paper provides a model to relate the position and rotation of the end-effector and the input including the flexible cable dynamics. The derived input-output model for the system is a set of delay-differential equations. We then apply the delta flatness theory to calculate the control inputs applied by the actuators at the end of the ropes for given trajectories for the six degrees-of-freedom of the system. The approach is illustrated by mathematical simulation in this paper.
ChemInform Abstract: Synthesis of Potent Agonists of the D‐myo‐Inositol 1,4,5‐Trisphosphate Receptor Based on Clustered Disaccharide Polyphosphate Analogues of Adenophostin A. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The thermal contact resistance of a steel-ceramic interface with oxide intermediates (2020)

&lt;p&gt;Metal structures covered by refractories are widely employed in high temperature processes such as incineration and metal production. The thermal resistance in refractories used in high temperature processes is associated with different phases, phase boundaries and porosity in the refractory and with the thermal contact resistance between the refractory and the metal interface. Here, a light flash method was used to evaluate the thermal contact resistance of the ceramic/steel interface at temperatures of 25, 100, 200, 300 and 400 °C. The material combinations studied were a commonly-used reference ceramic, Pyroceram 9606, and pressure vessel steel with oxidizing treatment at 450 and 650 °C for 50 h. Thermal resistance at a ceramic/steel interface increased significantly when a porous oxide layer was formed on the steel surface. The thermal contact resistance of the interface varied from 0.1 to 0.4 × 10&lt;sup&gt;−3&lt;/sup&gt; m&lt;sup&gt;2&lt;/sup&gt;K/W, depending on the temperature and the oxidization of the steel sample.&lt;/p&gt;
Millisecond-scale molecular dynamics simulations on Anton (2009)

Anton is a recently completed special-purpose supercomputer designed for molecular dynamics (MD) simulations of biomolecular systems. The machine's specialized hardware dramatically increases the speed of MD calculations, making possible for the first time the simulation of biological molecules at an atomic level of detail for periods on the order of a millisecond---about two orders of magnitude beyond the previous state of the art. Anton is now running simulations on a timescale at which many critically important, but poorly understood phenomena are known to occur, allowing the observation of aspects of protein dynamics that were previously inaccessible to both computational and experimental study. Here, we report Anton's performance when executing actual MD simulations whose accuracy has been validated against both existing MD software and experimental observations. We also discuss the manner in which novel algorithms have been coordinated with Anton's co-designed, application-specific hardware to achieve these results.
Linear system identification with derivative shift operator representations (2005)

A new operator which combines the two commonly used operators, the shift(q) and the delta(/spl delta/) operators is used in system identification. It is shown that by using this operator the condition number of the information matrix in the identification is significantly lower than that using the q or /spl delta/-operator. It is also shown that more accurate and faster converging parameter identification can be achieved by using the new operator especially for high order systems with wide bandwidth and when sampling rates are high. The numerical superiority of the new operator over the q- and /spl delta/-operator is demonstrated by simulation results.
NB-IoT Technology Overview and Experience from Cloud-RAN Implementation (2017)

The 3GPP has introduced a new narrowband radio technology called narrowband Internet of Things (NB-IoT) in Release 13. NB-IoT was designed to support very low power consumption and low-cost devices in extreme coverage conditions. NB-IoT operates in very small bandwidth and will provide connectivity to a large number of low-data-rate devices. This article highlights some of the key features introduced in NB-IoT and presents performance results from real-life experiments. The experiments were carried out using an early-standard-compliant prototype based on a software defined radio partial implementation of NB-IoT that runs on a desktop computer connected to the network. It is found that a cloud radio access network is a good candidate for NB-IoT implementation.
Aging of thin polyimide-ceramic and polycarbonate-ceramic composite membranes (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAging of thin polyimide-ceramic and polycarbonate-ceramic composite membranesMary E. Rezac, Peter H. Pfromm, Lora M. Costello, and William J. KorosCite this: Ind. Eng. Chem. Res. 1993, 32, 9, 1921–1926Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/ie00021a016https://doi.org/10.1021/ie00021a016research-articleACS PublicationsRequest reuse permissionsArticle Views307Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Figure 5 from SIRT1 Pathway Dysregulation in the Smoke-Exposed Airway Epithelium and Lung Tumor Tissue (2023)

&lt;p&gt;PDF file, 72K, SIRT1 and PI3K pathway activation in airway epithelial cells from current and formers smokers with and without lung cancer. CEL files from the training and test set samples in GSE4115 (n=129 samples, n=29 current smokers with lung cancer, n=22 current smokers without lung cancer, n=31 former smokers with lung cancer, n=26 former smokers without lung cancer) were processed as described in the methods. The pathway signature for PI3K was re-derived using the methods described above using a compendium of oncogenic signatures including BCAT, E2F3, MYC, p63, RAS, and SRC (GSE3151 and GSE12815). PI3K pathway activation probabilities for each sample were computed using the same methodology described for SIRT1. A. There is no significant difference in SIRT1 pathway activation between patients with and without lung cancer. SIRT1 is significantly activated in current smokers compared to former smokers (p&lt;0.001). B. PI3K is significantly activated in patients with lung cancer (p&lt;0.001).&lt;/p&gt;
Incongruent reaction of Cu–(InGa) intermetallic precursors in H2Se and H2S (2007)

The reaction pathways to form Cu(InGa)Se2 or Cu(InGa)S2 films at 450°C from metallic precursors were evaluated by reacting Cu–In–Ga films in H2Se or H2S for 10, 30, or 90min and characterizing the phase composition of the resulting films. A starting composition comprising Cu9(In0.64Ga0.36)4 and In phases was detected by x-ray diffraction in Cu–Ga–In precursors annealed at 450°C in an Ar atmosphere. When the precursors were reacted in H2Se, a graded Cu(InGa)Se2 film was formed with a Ga-rich composition and residual Cu–Ga intermetallics at the interface with the Mo back contact. The intermetallic compounds were observed to evolve from Cu9(In0.64Ga0.36)4 to Cu9Ga4 with increasing selenization time. Reaction in H2S formed inhomogeneous Cu(InGa)S2 with Cu–In intermetallics. The results are consistent with thermochemical predictions of the preferential reaction of In with Se, and Ga with S. These reaction preferences can explain the formation of a graded Cu(InGa)Se2 film during reaction in H2Se and provide a refined understanding of the reaction sequence in two-step H2Se∕H2S processes.
Small and High-Gain Array Antenna for WPT Over Several Meters (2019)

In this paper, an antenna is designed to generate an end-fire radiated beam of a very large gain for a PCB structure and steer the beam at an ISM-band. Different from other quasi-Yagi cases, the quasi-Yagi antenna is a flush-mounted or end-launch slot-coupled feed and is covered by two parasitic layers to increase the antenna gain. This is applied to a 1-by-8 array and the four layers of this 1D array are put in tandem. The layers are fed by a Butler matrix to steer the sharp end-fire beam. The stacked structure as a 2D array generate the titled beam moving from -35° to 35° with the antenna gain from 17 dBi to 20 dBi for a varying angle.
Blue photoluminescence from in situ Cu-doped porous silicon (2002)

We have observed weak blue photoluminescence from in situ Cu-doped porous silicon formed by electrochemical etching with a low etching current density that is aided by cuprous chloride [Cu(I)Cl]. Fourier transform infrared spectroscopy, x-ray photoelectron spectroscopy, and Auger electron spectroscopy reveal that the blue emission is associated with formation of the carbonyl group that is catalyzed by Cu on the surface of the porous silicon.
Linker Influence on the Stereochemical Outcome of Glycosylations Utilizing Solid Support-Bound Glycosyl Phosphates (2002)

[reaction: see text] Glycosyl phosphates can be readily accessed on a solid support via a three-step procedure from support-bound glycals. These resin-bound glycosyl phosphates were successfully used as glycosylating agents for coupling with a series of nucleophiles. The stereochemical outcome of disaccharide formation was dependent on the nature of the linker connecting the saccharide to the polymer. Interestingly, other glycosyl donors such as thioglycosides and trichloroacetimidates did not exhibit such a dependence, indicating a different reaction mechanism for glycosylation.
Coupling Methanol Denaturation, Immobilized Trypsin Digestion, and Accurate Mass and Time Tagging for Liquid-Chromatography-Based Shotgun Proteomics of Low Nanogram Amounts of RAW 264.7 Cell Lysate (2012)

We report the shotgun proteomic analysis of mammalian cell lysates that contain low nanogram amounts of protein. Proteins were denatured using methanol, digested using immobilized trypsin, and analyzed by UPLC-ESI-MS/MS. The approach generated more peptides and higher sequence coverage for a mixture of three standard proteins than the use of free trypsin solution digestion of heat- or urea-denatured proteins. We prepared triplicate RAW 264.7 cell lysates that contained 6, 30, 120, and 300 ng of protein. An average of 2 ± 1, 23 ± 2, 134 ± 11, and 218 ± 26 proteins were detected for each sample size, respectively. The numbers of both protein and peptide IDs scaled linearly with the amount of sample taken for analysis. Our approach also outperformed traditional methods (free trypsin digestion of heat- or urea-denatured proteins) for 6-300 ng RAW 264.7 cell protein analysis in terms of number of peptides and proteins identified. The use of accurate mass and time (AMT) tags resulted in the identification of an additional 16 proteins based on 20 peptides from the 6 ng cell lysate prepared with our approach. When AMT analysis was performed for the 6 ng cell lysate prepared with traditional methods, no reasonable peptide signal could be obtained. In all cases, roughly ∼30% of the digested sample was taken for analysis, corresponding to the analysis of a 2 ng aliquot of homogenate from the 6 ng cell lysate.
Validation of in vivo fluorochrome concentrations measured using fluorescence molecular tomography (2005)

Fluorescence molecular tomography (FMT) has emerged as a means of quantitatively imaging fluorescent molecular probes in three dimensions in living systems. To assess the accuracy of FMT in vivo, translucent plastic tubes containing a turbid solution with a known concentration of Cy 5.5 fluorescent dye are constructed and implanted subcutaneously in nude mice, simulating the presence of a tumor accumulating a fluorescent molecular reporter. Comparisons between measurements of fluorescent tubes made before and after implantation demonstrate that the accuracy of FMT reported for homogeneous phantoms extends to the in vivo situation. The sensitivity of FMT to background fluorescence is tested by imaging fluorescent tubes in mice injected with Cy 5.5-labeled Annexin V. For small tube fluorochrome concentrations, the presence of background fluorescence results in increases in the reconstructed concentration. This phenomenon is counteracted by applying a simple subtraction correction to the measured fluorescence data. The effects of varying tumor photon absorption are simulated by imaging fluorescent tubes with varying ink concentrations, and are found to be minor. These findings demonstrate the in vivo quantitative accuracy of fluorescence tomography, and encourage further development of this imaging modality as well as application of FMT in molecular imaging studies using fluorescent reporters.
Decreased Renal Function Among Adults With a History of Nephrolithiasis: A Study of NHANES III (2005)

No AccessJournal of UrologyUrological Survey: Urolithiasis, Endourology and Laparoscopy1 Aug 2005Decreased Renal Function Among Adults With a History of Nephrolithiasis: A Study of NHANES III Ralph V. ClaymanM.D. Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)68325-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Decreased Renal Function Among Adults With a History of Nephrolithiasis: A Study of NHANES III." The Journal of Urology, 174(2), pp. 600–601 © 2005 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 174Issue 2August 2005Page: 600-601 Advertisement Copyright & Permissions© 2005 by American Urological Association, Inc.MetricsAuthor Information Ralph V. Clayman More articles by this author Expand All Advertisement Loading ...
Natural materials for nano bio systems (2014)

Many papers have been published on the properties of deoxyribonucleic acid (DNA) and DNAhexadecyltrimethylammonium chloride (CTMA) and their applications in electronics and photonics. This paper is a review of some of the properties and their related applications for other types of naturally occurring materials, nucleic acid bases or nucleobases which make up the DNA molecules. Nucleobases under investigation included guanine, cytosine, adenine and thymine. Potential applications include electron blocking layers for organic light emitting diodes, gate dielectrics for organic thin film transistors and protective layers for polymer-based capacitors.
Plant Pathogenicity in Spaceflight Environments (1996)

Plants grown in microgravity are subject to many environmental stresses, which may promote microbial growth and result in pathogenicity to the plant. Recent plant experiments with super dwarf wheat aboard the NASA Space Shuttle and NASA/Russian Mir Space Station returned from the mission with severe degrees of fungal contamination. Understanding the cause of such microbial contamination and methods to eliminate it are necessary prerequisites for continued plant growth and development studies in micro gravity. A seed-borne fungal endophyte, an Acremonium species was identified in the seed used in both the spaceflight missions and was also recovered from the leaf sheaths of the symptomatic super dwarf wheat that was flown on the 8-day mission aboard U.S. Space Shuttle Discovery (CHROMEX-06, STS-63). The super dwarf wheat infected with the Acremonium endophyte was symptomless when grown under greenhouse conditions. Our data suggest that growth in spaceflight conditions (high relative humidity, high atmospheric carbon dioxide, low light and available nutrients) can induce the transition in the fungus from a symptomless to a pathogenic state on its plant host. Plant growth under spaceflight conditions enabled this Acremonium species to escape its asymptomatic endophytic existence and become pathogenic on super dwarf wheat.