gebhart/patrepeval huggingface dataset:
Simulation-Based Medical Planning for Cardiovascular Disease: Visualization System Foundations (2000)

AbstractA technique for visualizing computational models along with volumetric imaging data in a real-time, interactive, simulation-based medical planning system for cardiovascular disease treatment is described. This technique involves an ordered rendering of faceted geometry and volumetric image data. We have developed a software system based on this image-fusion technique that is capable of capturing and representing the inherent anatomic constraints of an individual patient. Such constraints must be represented accurately in a medical planning system to ensure the validity of a potential procedure. A hypothetical clinical scenario is described for which vascular treatment plans were constructed pre-operatively without reference to the physical anatomic smcture. These models were later embedded into patient-specific diagnostic MRA scans to establish the anatomic context for physiologic observations.Key Words: simulation-based medical planningcardiovascular disease treatmentimage fusionvolume-rendering
[N-({(R)-2-[(N-Benzylprolyl)amino]phenyl}phenylmethylene)-2(S)-(pent-4-enyl)glycinato]nickel(II) (2006)

The title compound, [Ni(C(32)H(33)N(3)O(3))], crystallized as a minor product during the purification of its 2(R)-pent-4-enyl diastereomer. Mixtures of the title compound and its enantiomer self-resolve.
Data from <i>In Vitro</i> and <i>In Vivo</i> Activity of IMGN853, an Antibody–Drug Conjugate Targeting Folate Receptor Alpha Linked to DM4, in Biologically Aggressive Endometrial Cancers (2023)

&lt;div&gt;Abstract&lt;p&gt;Grade 3 endometrioid and uterine serous carcinomas (USC) account for the vast majority of endometrial cancer deaths. The purpose of this study was to determine folic acid receptor alpha (FRα) expression in these biologically aggressive (type II) endometrial cancers and evaluate FRα as a targetable receptor for IMGN853 (mirvetuximab soravtansine). The expression of FRα was evaluated by immunohistochemistry (IHC) and flow cytometry in 90 endometrioid and USC samples. The &lt;i&gt;in vitro&lt;/i&gt; cytotoxic activity and bystander effect were studied in primary uterine cancer cell lines expressing differential levels of FRα. &lt;i&gt;In vivo&lt;/i&gt; antitumor efficacy of IMGN853 was evaluated in xenograft/patient-derived xenograft (PDX) models. Semiquantitative IHC analysis indicated that 41% of the USC patients overexpress FRα. Further, overexpression of FRα (i.e., 2+) was detected via flow cytometry in 22% (2/9) of primary endometrioid and in 27% (3/11) of primary USC cell lines. Increased cytotoxicity was seen with IMGN853 treatment compared with control in 2+ expressing uterine tumor cell lines. In contrast, tumor cell lines with low FRα showed no difference when exposed to IMGN853 versus control. IMGN853 induced bystander killing of FRα = 0 tumor cells. In an endometrioid xenograft model (END(K)265), harboring 2+ FRα, IMGN853 treatment showed complete resolution of tumors (&lt;i&gt;P&lt;/i&gt; &lt; 0.001). Treatment with IMGN853 in the USC PDX model (BIO(K)1), expressing 2+ FRα, induced twofold increase in median survival (&lt;i&gt;P&lt;/i&gt; &lt; 0.001). IMGN853 shows impressive antitumor activity in biologically aggressive FRα 2+ uterine cancers. These preclinical data suggest that patients with chemotherapy resistant/recurrent endometrial cancer overexpressing FRα may benefit from this treatment. &lt;i&gt;Mol Cancer Ther; 17(5); 1003–11. ©2018 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Unique Checkpoints During the First Cell Cycle of Fertilization After Intracytoplasmic Sperm Injection in Rhesus Monkeys (1999)

Hewitson, Laura; Dominko, Tanja; Takahashi, Diana; Martinovich, Crista; Ramalho-Santos, Joao; Sutovsky, Peter; Fanton, John; Jacob, Darla; Monteith, Daymond; Neuringer, Martha; Battaglia, David; Simerly, Cal; Schatten, Gerald Author Information
Current Water-Control Treatment Designs (1992)

ABSTRACT Despite significant improvements in completion technology, water production problems associated with encroachment, channeling, and coning still prevail in' many wells. In this paper, different types of water-producing wells are classified corresponding to their onset mechanisms. Various applications of polymers and cements in minimizing water-oil ratio are reviewed. Methods and limitations of current water control processes are evaluated. A general procedure for designing water-control treatments is presented. This paper also addresses difficulties existing in design and performance of water-control treatments. These include (1) lack of an extensive production history and knowledge of prior stimulation of wells requiring treatment, (2) lack of a systematic approach in treatment design, and (3) improper recovery techniques when returning the well to production. Results of wells treated in various fields are evaluated with respect to methods and chemicals used. Information presented in this paper will provide the completion engineer a broad knowledge of water-control treatment design parameters and chemical applications currently available within the industry.
Logical Interface Support for multi-mode IP Hosts (2010)

A Logical Interface is a software semantic internal to the host
operating system. This semantic is available in all popular operating
systems and is used in various protocol implementations. The Logical
Interface support is desirable on the mobile node operating in a Proxy
Mobile IPv6 domain, for leveraging various network-based mobility
management features such as inter-technology handoffs, multihoming and
flow mobility support. This document explains the operational details
of Logical Interface construct and the specifics on how the link-layer
implementations hide the physical interfaces from the IP stack and
from the network nodes. Furthermore, this document identifies the
applicability of this approach to various link-layer technologies and
analyses the issues around it when used in context with various
mobility management features.
Addressing spatial bias in intracranial EEG functional connectivity analyses for epilepsy surgical planning (2022)

<i>Objective.</i>To determine the effect of epilepsy on intracranial electroencephalography (EEG) functional connectivity, and the ability of functional connectivity to localize the seizure onset zone (SOZ), controlling for spatial biases.<i>Approach.</i>We analyzed intracranial EEG data from patients with drug-resistant epilepsy admitted for pre-surgical planning. We calculated intracranial EEG functional networks and determined whether changes in functional connectivity lateralized the SOZ using a spatial subsampling method to control for spatial bias. We developed a 'spatial null model' to localize the SOZ electrode using only spatial sampling information, ignoring EEG data. We compared the performance of this spatial null model against models incorporating EEG functional connectivity and interictal spike rates.<i>Main results.</i>About 110 patients were included in the study, although the number of patients differed across analyses. Controlling for spatial sampling, the average connectivity was lower in the SOZ region relative to the same anatomic region in the contralateral hemisphere. A model using intra-hemispheric connectivity accurately lateralized the SOZ (average accuracy 75.5%). A spatial null model incorporating spatial sampling information alone achieved moderate accuracy in classifying SOZ electrodes (mean AUC = 0.70, 95% CI 0.63-0.77). A model incorporating intracranial EEG functional connectivity and spike rate data further outperformed this spatial null model (AUC 0.78,<i>p</i>= 0.002 compared to spatial null model). However, a model incorporating functional connectivity without spike rate data did not significantly outperform the null model (AUC 0.72,<i>p</i>= 0.38).<i>Significance.</i>Intracranial EEG functional connectivity is reduced in the SOZ region, and interictal data predict SOZ electrode localization and laterality, however a predictive model incorporating functional connectivity without interictal spike rates did not significantly outperform a spatial null model. We propose constructing a spatial null model to provide an estimate of the pre-implant hypothesis of the SOZ, and to serve as a benchmark for further machine learning algorithms in order to avoid overestimating model performance because of electrode sampling alone.
An Analytical Model of Thermal and Vapor Diffusion in Freezing of Wet Coal (1985)

An analytical study is presented for the freezing of a semi-infinite domain of wet coal particles with special attention to the role of the airborne water vapor diffusion process. The results indicate that energy transport in this multiphase system can occur by means of thermal diffusion or mass diffusion. The magnitude of the Lewis number can be used to determine the mechanism. For a Lewis number smaller than 1, water vapor will evaporate from the coal particles, condense on the wall, and increase the freezing rate in the system.
Performance of multiuser diversity in the presence of feedback errors (2005)

We compare the performance of three physical layer scheduling algorithms: round robin; transmit time selection diversity (TTSD); maximum SNR. With TTSD, downlink transmission is suspended if the instantaneously received SNR in the mobile station falls below a given threshold, which requires only one feedback bit per user; this considerably decreases the overhead of the feedback signaling when compared with a maximum SNR scheduler. In the case of FDD systems, TTSD and maximum SNR schedulers require a fast feedback channel from mobile to base station, like the one in the FDD WCDMA system. It is shown that, while the maximum SNR scheduler outperforms the other two schedulers when the feedback signaling is error-free, TTSD is better in the case of feedback bit errors. Furthermore, while orthogonal space-time coding does not improve the performance with channel aware schedulers when compared to single antenna transmission, it is shown that space-time coding makes the system more robust and gives gain in the case of feedback errors.
Autonomous Needle Navigation in Retinal Microsurgery: Evaluation in ex vivo Porcine Eyes (2023)

Important challenges in retinal microsurgery include prolonged operating time, inadequate force feedback, and poor depth perception due to a constrained top-down view of the surgery. The introduction of robot-assisted technology could potentially deal with such challenges and improve the surgeon's performance. Motivated by such challenges, this work develops a strategy for autonomous needle navigation in retinal microsurgery aiming to achieve precise manipulation, reduced end-to-end surgery time, and enhanced safety. This is accomplished through real-time geometry estimation and chance-constrained Model Predictive Control (MPC) resulting in high positional accuracy while keeping scleral forces within a safe level. The robotic system is validated using both open-sky and intact (with lens and partial vitreous removal) <i>ex vivo</i> porcine eyes. The experimental results demonstrate that the generation of safe control trajectories is robust to small motions associated with head drift. The mean navigation time and scleral force for MPC navigation experiments are 7.208 s and 11.97 mN, which can be considered efficient and well within acceptable safe limits. The resulting mean errors along lateral directions of the retina are below 0.06 mm, which is below the typical hand tremor amplitude in retinal microsurgery.
Insulation Design for a Compact, Medium-Voltage Transformer (2022)

The purpose of this work is to develop a compact hatchable, medium-voltage transformer for electric ship power distribution systems. To achieve this, this work proposes a new transformer design capable of operating at 500 kHz and 250 kW and providing 20 kV isolation. The proposed design separates the primary and secondary sides of the transformer with a mica insulation sheet and employs a planar winding arrangement. To distribute the electric field along the mica sheet, a pair of conductive and semiconductive layers are used. The transformer prototype is 30 x 25 x 10 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> , passes a 30 kV HiPot test, and achieves 99.5% efficiency.
High Affinity Binding of Idazoxan to a Non‐Catecholaminergic Binding Site in the Central Nervous System: Description of a Putative Idazoxan‐Receptor (1989)

Pharmacology & ToxicologyVolume 64, Issue 1 p. 152-155 High Affinity Binding of Idazoxan to a Non-Catecholaminergic Binding Site in the Central Nervous System: Description of a Putative Idazoxan-Receptor Jarl E. S. Wikberg, Jarl E. S. Wikberg Department of Pharmacology, Umeå University, S-901 87 Umeå, SwedenSearch for more papers by this author Jarl E. S. Wikberg, Jarl E. S. Wikberg Department of Pharmacology, Umeå University, S-901 87 Umeå, SwedenSearch for more papers by this author First published: January 1989 https://doi.org/10.1111/j.1600-0773.1989.tb00620.xCitations: 49AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume64, Issue1January 1989Pages 152-155 RelatedInformation
Investigation of the Effect of Graphene-encapsulation on the O2 Release Phenomenon from LixCoO2, Studied by In-situ Heating STEM/EELS (2018)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Dense pattern multiple pass cells (2023)

An optical cell and a method of operating an optical cell comprising employing a first mirror comprising a first hole therein at approximately a center of the first mirror and through which laser light enters the cell, employing a second mirror comprising a second hole therein at approximately a center of the second mirror and through which laser light exits the cell, and forming a Lissajous pattern of spots on the mirrors by repeated reflection of laser light entering the cell.
Assessment of Breast Cancer by Magnetic Resonance Elastography (1999)

Introduction Breast palpation is an important screening tool for breast cancer. Approximately one third of breast cancers in some series are detected only by palpation and not by mammography [1]. Unfortunately, many lesions are too small or too deep to detect early by physical exam. Because tumors are usually much stiffer than normal surrounding tissue, changes in tissue elasticity have been shown to be a sensitive indicator of pathology [2]. Available conventional imaging modalities can not directly measure these mechanical properties, thus providing motivation for the development of alternative imaging techniques. Previously we described a technique using magnetic resonance imaging to visualize propagating acoustic shear waves, allowing for the quantification of the elastic properties of tissues [3,4]. Previous work in normal breast volunteers has shown that this technique, called magnetic resonance elastography (MRE), is feasible in-vivo and is capable of evaluating the elastic properties of normal fatty and glandular breast tissue [5]. The objective of this work is 1) to determine if MRE is capable of delineating known breast cancer tissue from normal tissues in-vivo, and 2) to quantify the shear modulus of various breast cancers in-vivo.
Clinical Relevance of Pathogens Detected by Multiplex PCR in Blood of Very-Low-Birth Weight Infants with Suspected Sepsis – Multicentre Study of the German Neonatal Network (2016)

Multiplex-PCR results had a moderate impact on clinical management in about one third of LOS-episodes. The main advantage of multiplex-PCR was the rapid detection of pathogens from micro-volume blood samples. In VLBWI limitations include risk of contamination, lack of resistance testing and high costs. The high rate of positive PCR results in episodes of negative BC might lead to overtreatment of infants which is associated with risk of mortality, antibiotic resistance, fungal sepsis and NEC.
Impact on Performance, Positive Bias Temperature Instability, and Time-Dependent Dielectric Dreakdown of n-Type Field Effect Transistors Incorporating Mg into HfSiON Gate Dielectrics (2009)

We have investigated the effect on the device performance and reliability of incorporating Mg into the HfSiON gate dielectrics. Mg incorporation is effective for reducing the threshold voltage and gate leakage current in n-type metal–oxide–semiconductor field effect transistor. On the other hand, it may introduce interface states and degrade the mobility if the Mg atoms come close to the interface between the Si substrate and the gate oxide. Nonetheless, Mg incorporation has great potential for improving reliability, including positive bias temperature instability (PBTI) and time-dependent dielectric breakdown (TDDB). Its reliability improvement is mainly caused by gate leakage current reduction and trap density suppression as an result of Mg incorporation.
Exploring Passive Clearing for 3D Optical Imaging of Nanoparticles in Intact Tissues (2016)

The three-dimensional (3D) optical imaging of nanoparticle distribution within cells and tissues can provide insights into barriers to nanoparticle transport in vivo. However, this approach requires the preparation of optically transparent samples using harsh chemical and physical methods, which can lead to a significant loss of nanoparticles and decreased sensitivity of subsequent analyses. Here, we investigate the influence of electrophoresis and clearing time on nanoparticle retention within intact tissues and the impact of these factors on the final 3D image quality. Our findings reveal that longer clearing times lead to a loss of nanoparticles but improved transparency of tissues. We discovered that passive clearing improved nanoparticle retention 2-fold compared to results from electrophoretic clearing. Using the passive clearing approach, we were able to observe a small population of nanoparticles undergoing hepatobiliary clearance, which could not be observed in liver tissues that were prepared by electrophoretic clearing. This strategy enables researchers to visualize the interface between nanomaterials and their surrounding biological environment with high sensitivity, which enables quantitative and unbiased analysis for guiding the next generation of nanomedicine designs.
Abstract A176: RET inhibition: Development of novel compounds and a personalized medicine strategy in lung adenocarcinoma (2015)

Abstract Background:RET is a receptor tyrosine kinase (RTK) and forms part of a macromolecular receptor complex containing dimerised RET receptor, two co-receptors and a bound ligand. Signalling networks downstream of RET play an important role in regulating cell survival, differentiation, proliferation, migration and chemotaxis. Activating mutations in RET (e.g. C634W and M918T) are known drivers in medullary thyroid carcinomas (MTC). More recently, oncogenic RET fusions (e.g. CCDC6-RET and KIF5B-RET) have been identified in 1-2% of lung adenocarcinoma patients. We are currently developing novel, selective inhibitors of RET, and at the same time, investigating a number of biomarker approaches for the stratification of RET fusion-positive lung cancer patients who might benefit from such therapy. Methods: We have undertaken collaborative studies using established techniques including immunohistochemistry (IHC) and FISH (DNA break apart and RNA). In addition, we have investigated hybrid capture DNA sequencing of both biopsy material and circulating tumour DNA in the blood. Here we, compare and contrast the benefits of each biomarker assay evaluated and consider how these approaches could be translated for use in Phase I clinical trials at The Christie. Conclusion: Our data supports the successful implementation of predictive biomarkers to identify patients who might benefit from treatment with selective RET inhibitors. Acknowledgements:This work was funded by Cancer Research UK (Grant numbers C480/A1141 and C5759/A17098). Citation Format: Mandy Watson, Helen Small, Phil Chapman, Gemma Hopkins, Habiba Begum, Ian D. Waddell, Garry Ashton, Caron Abbey, Jade Harris, Mahmood Ayub, Sumitra Mohan, Dominic Rothwell, Ged Brady, Caroline Dive, Allan Jordan, Donald Ogilvie. RET inhibition: Development of novel compounds and a personalized medicine strategy in lung adenocarcinoma. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2015 Nov 5-9; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr A176.
Molecular Simulation of Ultrathin Polymeric Films near the Glass Transition (2000)

Properties such as the glass transition temperature ( T(g)) and the diffusion coefficient of ultrathin polymeric films are shown to depend on the dimensions of the system. In this work, a hard-sphere molecular dynamics methodology has been applied to simulate such systems. We investigate the influence that substrates have on the behavior of thin polymer films; we report evidence suggesting that, depending on the strength of substrate-polymer interactions, the glass transition temperature for a thin film can be significantly lower or higher than that of the bulk.
Supplementary Figure 6 from Distinct Effects of Ligand-Induced PDGFRα and PDGFRβ Signaling in the Human Rhabdomyosarcoma Tumor Cell and Stroma Cell Compartments (2023)

&lt;p&gt;PDF file - 669K, CP-673,451 treatment does not affect growth of tumors derived from the RMS cell line. A, PDGFRβ expression in infiltrating stroma. B, RMS tumor growth in response to CP-673,451 or vehicle (n≥9 mice/group).&lt;/p&gt;
Simulation of the Anneal of Ion Implanted Boron Emitters and the Impact on the Saturation Current Density (2012)

Recently, the interest for the implementation of local ion implantation for emitter formation has been renewed, as it results in high cell efficiencies [1], while the amount of process steps is reduced. After implantation, a thermal diffusion (annealing) is necessary for the removal of the ion-induced damage, the activation of dopants and the formation of the desired profile shape. The goal is to change the implanted retrograde near surface (10-100 nm) inactive profile, into a damage free, box-like shaped, and fully active emitter (or BSF) with a low saturation current density (J0e). Here, we study different post-implantation annealing schemes, to achieve high performance boron emitters for n-type IBC solar cells. We show experimentally, that the use of oxygen gas during the boron anneal has an impact on the electrical performance (J0e) of the emitter. On the other hand, the obtained J0e values are higher than those obtained by the standard diffusion approach. Hence, in order to understand these results and optimize the implant/anneal process, the modeling of the profile shape and the damage evolution would be extremely valuable. In this work, we report on our initial simulation results, and we demonstrate the impact of oxygen on the evolution of the profile shapes of the implanted B-emitters after anneal, taking into account boron diffusion kinetics mechanisms such as Transient Enhanced Diffusion (TED) and Oxidation Enhanced Diffusion (OED). Moreover, we monitor the residual damage and we make a first effort to correlate the increase on the J0e values with the residual damage levels. Throughout this work, we adopt the process simulator tool Sentaurus Process.