gebhart/patrepeval huggingface dataset:
Poly(sebacic acid-co-ricinoleic acid) Biodegradable Injectable in Situ Gelling Polymer (2005)

The investigated polymers, poly(sebacic acid-co-ricinoleic acid) containing > or =70% ricinoleic acid, may be injected via a 22 gauge needle and become gel upon contact with aqueous medium, both in vitro and in vivo. Various properties of the polymers including viscosity, thermal analysis, and in vivo behavior, before and after exposure to aqueous medium, were determined. These polymers were observed using scanning electron microscopy (SEM) at dry and wet states. It was found that the viscosity and melting temperature of P(SA:RA) increased after exposure to buffer. The viscosity at 37 degrees C of P(SA:RA)3:7 had the highest increase: from 4200 cP before to 8940 cP after exposure to buffer; in the case of P(SA:RA)25:75 before exposure to buffer the viscosity was 1150 cP while after it raised to 3200 cP. The viscosity of P(SA:RA)2:8 also increased from 400 cP before exposure to buffer to 1000 cP after. On the other hand polymer without sebacic acid, (poly(ricinoleic acid)), did not show gelation properties. Thermal analysis also showed an increase in the melting point of the polymers exposed to the aqueous medium during the first 24 h of incubation. Images obtained by SEM showed formation of a three-dimensional network in polymers exposed to buffers. When injected into animals, P(SA:RA) forms a solid implant in the injection site already at 8 h postinjection.
Abstract 2500: Paroxysmal Atrial Fibrillation Detected By Prolonged Ambulatory Cardiac Monitoring In Patients With Cryptogenic Stroke: A Case-Control Study (2012)

Background: Whether a significant proportion of cryptogenic stroke (CS) is caused by under-detected paroxysmal atrial fibrillation (PAF) is not known. Prolonged ambulatory cardiac monitoring may detect episodes of PAF in patients with stroke of unknown cause (cryptogenic stroke, CS). However, it is unclear whether PAF is more common in patients wtih CS compared with patients with stroke of known cause (SKC). We performed a case control study to compare the rates of detection of PAF in CS vs SKC using prolonged ambulatory cardiac rhythm monitoring. Methods and Results: We prospectively enrolled 132 patients within 3 months of a stroke (66 with CS and 66 with SKC) to undergo 3-week ambulatory cardiac rhythm monitoring using the CardioNet MCOT system. Stroke group was assigned by consensus between two vascular neurologists upon enrollment based on the Causative Classification of Stroke system. Primary endpoint was detection of PAF of any duration independently confirmed by two cardiologists blinded to the stroke group. The groups were well balanced except that patients with CS tended to be older and to have less hypertension and diabetes. Four patients (2 in each group) were excluded because of insufficient stroke evaluation or early discontinuation of monitoring. Episodes of PAF were detected in 16/64 (25%) patients with CS and 9/64 (14%) patients with SKC (p=0.12). Only 5 patients had episodes of PAF lasting &gt; 30 seconds (3 with CS and 2 with SKC). Six of the 9 patients from the SKC group with PAF had small subcortical infarctions; the other 3 had cortical strokes ascribed to artery-to-artery embolism (2 with complex aortic plaques, 1 with severe vertebrobasilar stenosis). In patients under age 65, episodes of PAF were more common in the CS group (22% vs 3; p=0.07) while in patients age 65 or older the rates of detection were very similar (29% in CS vs 28% in SKC; p=0.9). Conclusions: Very short episodes of PAF are relatively common in patients with CS and with SKC, and their pathogenic significance is unclear. However, considering only patients under 65, a greater proportion of cryptogenic stroke patients had PAF, suggesting it might be pathogenic.
Synthesis of Novel Indolo‐Spirocyclic Compounds (2015)

In the present work, we succeeded to synthesize the novel indolo‐spirocyclic compounds ( 4 , 5 , 6 , 7 and 11 ) via electrophilic condensation reactions of indoles with carbonyl compounds including different types of ketones, for example, heteroacetyl ketones (3‐acetylindole and 3‐acetylpyridine), cyclohexanone, isatin, cyclohexane‐1,4‐dione, whereas an attempt to prepare the spirocyclic 9 failed. This new idea will open a high prospective for continuous investigations related to the synthesis of novel indolo‐spirocyclic compounds.
Relations among canine intestinal motility, blood flow, and oxygenation (1986)

Blood flow, arteriovenous O2 difference, and lumen pressure were measured in isolated loops of canine ileum. Ileal pressure was increased by an intra-arterial infusion of either Met-enkephalin or acetylcholine. Pressures were quantitated using a motility index (MI = mean of the pressure peaks divided by number of contractions per minute). Both Met-enkephalin and acetylcholine increased MI in a dose-dependent fashion. The highest MI achieved with acetylcholine was 37.9 mmHg, while Met-enkephalin produced a maximal MI of 8.1 mmHg. Ileal oxygen uptake increased when MI reached values greater than 6. There was a direct linear relationship between oxygen uptake and MI. Distension of the lumen in the absence of motility resulted in a decrease in oxygen uptake when lumen pressure reached 15-20 mmHg. The results of these studies indicate that contractions of intestinal smooth muscle can increase intestinal oxygen uptake and may contribute to the overall oxygen demands of the gut under conditions of fasting and feeding. Furthermore, large (greater than 20 mmHg) increments in lumen pressure during enhanced motility may compromise intestinal oxygenation.
Direct observation of the formation and stabilization of metallic nanoparticles on carbon supports (2020)

Direct formation of ultra-small nanoparticles on carbon supports by rapid high temperature synthesis method offers new opportunities for scalable nanomanufacturing and the synthesis of stable multi-elemental nanoparticles. However, the underlying mechanisms affecting the dispersion and stability of nanoparticles on the supports during high temperature processing remain enigmatic. In this work, we report the observation of metallic nanoparticles formation and stabilization on carbon supports through in situ Joule heating method. We find that the formation of metallic nanoparticles is associated with the simultaneous phase transition of amorphous carbon to a highly defective turbostratic graphite (T-graphite). Molecular dynamic (MD) simulations suggest that the defective T-graphite provide numerous nucleation sites for the nanoparticles to form. Furthermore, the nanoparticles partially intercalate and take root on edge planes, leading to high binding energy on support. This interaction between nanoparticles and T-graphite substrate strengthens the anchoring and provides excellent thermal stability to the nanoparticles. These findings provide mechanistic understanding of rapid high temperature synthesis of metal nanoparticles on carbon supports and the origin of their stability.
DEOXYSPERGUALIN IN LETHAL MURINE GRAFT-VERSUS-HOST DISEASE (1991)

The beneficial effect of deoxyspergualin (DSG, NKT-01) on lethal graft-versus-host disease in mice has been studied in a major histoincompatible donor-recipient combination. Suppression of the effector mechanisms responsible for the lethal outcome in this GVHD model is also noted. This study reveals: (1) DSG has a marked potential for treatment of lethal GVHD; (2) DSG and methotrexate in combination yield longer survival times than DSG or MTX alone; (3) long-term survivors, following DSG treatment, become stable chimeras as evidenced by cell-surface analysis of spleen cells; and (4) high activity of H-2-reactive cytotoxic T lymphocytes is detected in spleens of the mice with lethal GVHD, whereas natural killer activity is only slightly increased. DSG inhibits CTL activity not only in the induction stage but also in the advanced stage of the disease. These findings indicate that DSG might be beneficial in clinical bone marrow transplantation either alone or in combination with MTX.
Identification of Monoclonal Antibodies Capable of Differentiating Antigenic Varieties of Eastern Equine Encephalitis Viruses (1990)

We have isolated and characterized 3 monoclonal antibody (Mab) reagents useful in the serological identification of varieties of eastern equine encephalitis (EEE) viruses. These antibodies were specific for the E1 glycoprotein of their homologous viruses. One Mab, 1B5C-3, reacted specifically with all North American (NA) EEE viruses isolated over a 50 year period. This antigenic stability of NA isolates was genetically confirmed by oligonucleotide fingerprinting. Evolutionary stability is a unique feature among alphaviruses. The Mab, 1C1J-4 reacted specifically with 1 South American isolate of EEE virus. A third Mab, 1B1C-4, was EEE virus complex reactive. While none of these antibodies had virus neutralizing activity, the identified reactivities could be demonstrated in the more rapid serological tests of enzyme-linked immunosorbent assay and indirect immunofluorescence.
Source Coding for a Multihop Network (2005)

Summary form only given. In this paper, we bound the rate-distortion region for a four-node network. The results are the first known expansion of rate-distortion theory from single-hop networks (every source has a direct connection to each of its destinations), to multihop networks, which allow intermediate nodes. While single-hop network source coding solutions may be applied in multihop networks, such applications require explicit rate allocation for each source-destination pair, and the resulting solutions may be suboptimal. We therefore tackle the multihop network source coding problem directly using a diamond network.
Structures and bioactivity of alkaloids from Stemona (2007)

The roots of Stemona species (Stemonaceae) have been used as antitussive agent and insecticide for thousands of years in Traditional Chinese Medicine. Alkaloids, present as the main components in the roots of this plant, are believed to be responsible for its bioactivities. In our systematical investigation on the five main Stemona species in China, more than 60 alkaloids were isolated and structure identified. Those alkaloids, according to their structural characteristics, could be classified into seven subtypes, namely stemofoline-type, protostemonine-type, maistemonine-type, tuberostemonine-type, croomine-type, stemoninine-type and parvistemonine-type.
Real-Time High-Resolution MRI Endoscopy at up to 10 Frames per Second (2021)

<i>Objective</i>. Atherosclerosis is a leading cause of mortality and morbidity. Optical endoscopy, ultrasound, and X-ray offer minimally invasive imaging assessments but have limited sensitivity for characterizing disease and therapeutic response. Magnetic resonance imaging (MRI) endoscopy is a newer idea employing tiny catheter-mounted detectors connected to the MRI scanner. It can see through vessel walls and provide soft-tissue sensitivity, but its slow imaging speed limits practical applications. Our goal is high-resolution MRI endoscopy with real-time imaging speeds comparable to existing modalities. <i>Methods</i>. Intravascular (3 mm) transmit-receive MRI endoscopes were fabricated for highly undersampled radial-projection MRI in a clinical 3-tesla MRI scanner. Iterative nonlinear reconstruction was accelerated using graphics processor units connected via a single ethernet cable to achieve true real-time endoscopy visualization at the scanner. MRI endoscopy was performed at 6-10 frames/sec and 200-300 <i>μ</i>m resolution in human arterial specimens and porcine vessels <i>ex vivo</i> and <i>in vivo</i> and compared with fully sampled 0.3 frames/sec and three-dimensional reference scans using mutual information (MI) and structural similarity (3-SSIM) indices. <i>Results</i>. High-speed MRI endoscopy at 6-10 frames/sec was consistent with fully sampled MRI endoscopy and histology, with feasibility demonstrated <i>in vivo</i> in a large animal model. A 20-30-fold speed-up vs. 0.3 frames/sec reference scans came at a cost of ~7% in MI and ~45% in 3-SSIM, with reduced motion sensitivity. <i>Conclusion</i>. High-resolution MRI endoscopy can now be performed at frame rates comparable to those of X-ray and optical endoscopy and could provide an alternative to existing modalities, with MRI's advantages of soft-tissue sensitivity and lack of ionizing radiation.
An Agile, Ultra-Wideband Pulse Radio Transceiver With Discrete-Time Wideband-IF (2009)

A pulse-based CMOS ultra-wideband transmitter and receiver have been realized using a standard digital 90 nm CMOS process. The transceiver uses digital templates stored in high-speed memories for pulse generation on the transmit side and for correlation on the receive side. This allows fast band switching for multi-band operation and interferer avoidance without the requirement for fast-settling phase-locked loops. The receiver contains a 3.1-9.5 GHz broadband front-end and discrete-time intermediate frequency correlators that achieve a pulse rate of 100 Mpulses/s and has a die area of 1 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> while consuming 130 mA from a 1.2 V supply. The transmitter uses interleaved, intermediate frequency digital-to-analog converters followed by partial-order hold reconstruction filters that eliminate sampling images, and a quadrature RF up-converter. 1.25 nJ is spent per transmitted pulse for a pulse-repetition rate of 100 MHz while achieving a broadband image cancellation of 42 dB.
Tropane‐Based Alkaloids as Muscarinic Antagonists for the Treatment of Asthma, Obstructive Pulmonary Disease, and Motion Sickness (2012)

This chapter contains sections titled: Introduction History Synthesis Mode of Action Structure–Activity Relationships References
Identification of Functional Cell Adhesion Molecules with a Potential Role in Metastasis by a Combination of in vivo Phage Display and in silico Analysis (2007)

Organ-specific homing of malignant cells involves interactions mediated through cell adhesion molecules and their receptors on the cell surface. Identification of peptides that mimic these receptor-ligand interactions is critical for analyzing the functional role of these proteins and is therapeutically significant to target or block organ-specific homing of tumor cells. Following three cycles of in vivo biopanning using a phage display peptide library injected into mice, we identified 11 unique peptides that were specific for homing to lung, liver, bone marrow, or brain. We developed a bioinformatics strategy to identify putative cell adhesion molecules (CAM) involved in tumor cell migration, invasion, and metastasis based on identified organ-specific peptides. Structural information, including surface exposure and the binding preference of any of these residues in the identified proteins, was examined. These studies resulted in identification of Semaphorin 5A (mouse, Sema5A; human, SEMA5A) and its receptor Plexin B3. The gene expression profile of these proteins in tumors and tumor cell lines was assessed using virtual microarray and serial analysis of gene expression (SAGE) databases and was further confirmed using reverse transcriptase polymerase chain reaction (RT-PCR). Our data demonstrate an association between the expression of SEMA5A and Plexin B3 and the aggressiveness of pancreatic and prostate cancer cells. In summary, using a combined experimental and bioinformatics approach, we have identified functional tumor-specific CAMs, which may be critical for organ-specific metastasis.
A heptanucleotide sequence mediates ribosomal frameshifting in mammalian cells (1993)

Ribosomal frameshifting is an essential requirement for replication of many viruses and retrovirus-like elements. It is regarded as a potential target for antiretroviral therapy. It has been shown that the frameshifting event takes place in the -1 direction within a sequence, the slippery sequence, which is usually followed by structured RNA. To distinguish between the basic sequence requirements and the modulating elements in intact cells, we have established a sensitive assay system for quantitative determination of ribosomal frameshifting in mammalian cell culture. In this assay system, the gag and pol genes of human immunodeficiency virus type 1 are replaced by the genes for the functional enzymes beta-galactosidase and luciferase, respectively. The sensitivity of the test system allows us to demonstrate for the first time that the slippery sequence, a heptanucleotide, is sufficient to mediate a basal level of ribosomal frameshifting independent of its position within a gene. The stem-loop sequence serves only as a positive modulator. These data indicate that frameshifting could also occur during translation of cellular genes in which a slippery sequence is present within the reading frame. The resulting putative transframe proteins might have a functional importance for cellular processes.
Glass-embedded two-dimensional silicon photonic crystal devices with a broad bandwidth waveguide and a high quality nanocavity (2010)

To enhance the mechanical stability of a two-dimensional photonic crystal slab structure and maintain its excellent performance, we designed a glass-embedded silicon photonic crystal device consisting of a broad bandwidth waveguide and a nanocavity with a high quality (Q) factor, and then fabricated the structure using spin-on glass (SOG). Furthermore, we showed that the refractive index of the SOG could be tuned from 1.37 to 1.57 by varying the curing temperature of the SOG. Finally, we demonstrated a glass-embedded heterostructured cavity with an ultrahigh Q factor of 160,000 by adjusting the refractive index of the SOG.
Direct Measurement of the Fermi Energy in Graphene Using a Double Layer Structure (2011)

We describe a technique which allows a direct measurement of the relative Fermi energy in an electron system using a double layer structure, where graphene is one of the two layers. We illustrate this method by probing the Fermi energy as a function of density in a graphene monolayer, at zero and in high magnetic fields. This technique allows us to determine the Fermi velocity, Landau level spacing, and Landau level broadening in graphene. We find that the N=0 Landau level broadening is larger by comparison to the broadening of upper and lower Landau levels.
An adaptive equalizer based on particle swarm optimization techniques (2007)

Adaptive equalization is important due to its need for reducing inter-symbol interference in digital communication. In this work, particle swarm optimization (PSO) is adopted for designing adaptive equalizers. The effectiveness of the PSO algorithms in channel equalization is investigated. Different modifications of the original PSO technique are discussed and a new modification is proposed. The performance of various PSO algorithms is compared to that of the conventional LMS algorithm. Extensive simulation work has shown the superior performance of the proposed PSO-based adaptive equalizer over its LMS-based counterpart.
A distributed differential space-time coding scheme for two-way wireless relay networks (2009)

We propose a distributed differential space-time coding scheme for two-way relaying over unknown block Rayleigh fading channels. The accent is on a two-time slots scheme, where in the first stage both terminals transmit their signals to the relays and in the second stage the relays broadcast to the terminals. Although we do not assume channel knowledge neither at the relays nor at the terminals, we show that it is possible for the terminals to subtract their contribution from the broadcasted signal and decide on the desired signal from the other terminal. The performance analysis reveals that the two-time slots differential scheme offers advantage over the traditional four-time slots differential scheme.
Actinic mask inspection using EUV microscope (2004)

EUV lithography (EUVL) will introduce as next generation lithography of 32 nm node in 2009. Defect-free mask fabrication is one of the technical issue to achieve EUVL. There are two types of defects in EUVL mask: amplitude defect and phase defect. However, phase defect due to the multilayer fabrication can not be resolved with an existing inspection tool.
Infilling of Pore Spaces in Mortar Using Electrically-Driven Solution Transport Systems (2010)

It has been widely established that all types of conventional concrete can be strengthened by reducing the porosity of the concrete matrix. Attempts to infill the pores by converting reactive phases such as calcium hydroxide into calcium carbonate have been partly successful, but the success of this approach has been limited by the amount of Ca(OH)2 produced in the hydration of the concrete and by the positions of the new crystalline phases that are formed. These limitations can be overcome by using a combination of electrophoresis to move particles into concrete pores and the use of ion transport to move new dissolved reactants into the concrete mass. Bench scale experiments have demonstrated that significant density and strength increases can be obtained by electrophoretically moving seed crystals of selected mineral phases such as calcite, aragonite, or vaterite into the larger pores in concrete and then using a low‐voltage DC current to migrate in calcium and carbonate ions to grow the selected crystalline phases in masses sufficient to fill up both large and small pores. This can be done in such a way as to leave even the reactive phases such as Ca(OH)2 unaltered. The bulk pH of the concrete is not reduced in the mineralization process as it would be in simple carbonation. Pore in‐filling using electrophoretic and electro‐transport systems can potentially be of use in creating very high‐density concrete for concrete pipes, and panels with lower porosity than can be obtained using carbonation or pressure infiltration.
μNeurocircuitry: Establishing in vitro models of neurocircuits with human neurons (2017)

Neurocircuits in the human brain govern complex behavior and involve connections from many different neuronal subtypes from different brain regions. Recent advances in stem cell biology have enabled the derivation of patient-specific human neuronal cells of various subtypes for the study of neuronal function and disease pathology. Nevertheless, one persistent challenge using these human-derived neurons is the ability to reconstruct models of human brain circuitry. To overcome this obstacle, we have developed a compartmentalized microfluidic device, which allows for spatial separation of cell bodies of different human-derived neuronal subtypes (excitatory, inhibitory and dopaminergic) but is permissive to the spreading of projecting processes. Induced neurons (iNs) cultured in the device expressed pan-neuronal markers and subtype specific markers. Morphologically, we demonstrate defined synaptic contacts between selected neuronal subtypes by synapsin staining. Functionally, we show that excitatory neuronal stimulation evoked excitatory postsynaptic current responses in the neurons cultured in a separate chamber.