gebhart/patrepeval huggingface dataset:
Determination of NMR spin coupling constants using J-cross polarization. A comment on "J-Cross polarization in silanes (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of NMR spin coupling constants using J-cross polarization. A comment on "J-Cross polarization in silanesG. C. Chingas, R. D. Bertrand, A. N. Garroway, and W. B. MonizCite this: J. Am. Chem. Soc. 1979, 101, 15, 4058–4059Publication Date (Print):July 1, 1979Publication History Published online1 May 2002Published inissue 1 July 1979https://pubs.acs.org/doi/10.1021/ja00509a007https://doi.org/10.1021/ja00509a007research-articleACS PublicationsRequest reuse permissionsArticle Views90Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Botulinum toxin: issues and applications (1999)

Botulinum toxin is becoming a useful therapeutic toll for the treatment of many diseases in several disciplines. Following its application for regional movement disorders, such as blepharospasm, strabismus, and spasmodic torticollis, this agent is now being used for the treatment of certain pain syndromes and in facial cosmetic applications. Despite the proliferation in use, issues involving the pharmocology of materials and bioeffects that are important to this therapy are only partially understood. In this review, some recent published literature on newer applications and significant issues pertinent to this important technology are outlined.
Immobilization of a Rh-based Organometallic Catalyst within Metal-Organic Framework (2015)

National @ ING+JEC:JOB:DFA
Post-Transcriptional Regulation of 5-Lipoxygenase mRNA Expression via Alternative Splicing and Nonsense-Mediated mRNA Decay (2012)

5-Lipoxygenase (5-LO) catalyzes the two initial steps in the biosynthesis of leukotrienes (LT), a group of inflammatory lipid mediators derived from arachidonic acid. Here, we investigated the regulation of 5-LO mRNA expression by alternative splicing and nonsense-mediated mRNA decay (NMD). In the present study, we report the identification of 2 truncated transcripts and 4 novel 5-LO splice variants containing premature termination codons (PTC). The characterization of one of the splice variants, 5-LOΔ3, revealed that it is a target for NMD since knockdown of the NMD factors UPF1, UPF2 and UPF3b in the human monocytic cell line Mono Mac 6 (MM6) altered the expression of 5-LOΔ3 mRNA up to 2-fold in a cell differentiation-dependent manner suggesting that cell differentiation alters the composition or function of the NMD complex. In contrast, the mature 5-LO mRNA transcript was not affected by UPF knockdown. Thus, the data suggest that the coupling of alternative splicing and NMD is involved in the regulation of 5-LO gene expression.
Immunogenic HLA-B7-restricted peptides of hTRT (2006)

Telomerase reverse transcriptase (TRT) is the first bona fide common tumor antigen. While several 9mer peptides of the human TRT have been identified for HLA-A2, little information exists on peptides for the remaining HLA types. Here, we used a multi-step approach to select and characterize a panel of HLA-B7 9mer peptides as candidate immunogens. In sequence, we used algorithm-based predictions, in vivo immunization of HLA-B7 transgenic (Tg) mice, in vitro immunization of human blood lymphocytes from two normal donors and two cancer patients, in vivo processing in HLA-B7 Tg mice and HLA-B7 supertype binding. We found a correlation between the in vivo immunogenicity and the actual HLA-B7 binding avidity of the seven predicted peptides. Furthermore, endogenous processing correlated with in vitro immunogenicity in human PBMC and HLA-B7 supertype binding. Peptide (1123)LPSDFKTIL(1131) (p1123) with the wider spectrum of supertype binding displayed the highest immunogenicity overall and was endogenously processed in several human lymphoblastoid cells. Since no single step of the screening/selection process could substitute for the whole approach, we conclude that the identification of MHC class I-restricted peptides for potential vaccination of cancer patients remains, by and large, an empirical process.
Visualization of the pH Response through Autofluorescent Poly(styrene-alt-N-maleimide) Polyelectrolyte Brushes (2023)

Polyelectrolyte brushes can undergo reversible conformational transitions in response to changes in environmental pH and ionic strength. Therefore, they offer great potential for the design of “smart” surfaces and surface-based sensing devices. Herein, we report weak acidic polyelectrolyte brushes with pH-dependent autofluorescence based on alternating copolymers of styrene and tailor-made N-maleimides, which exhibit “clusteroluminescence” due to the through-space conjugation of π-chromophoric subfluorophores. Swelling behavior of the polyelectrolyte brushes was evaluated as a function of pH via in-solution atomic force microscopy (AFM) analyses. The correlation between the pH-induced conformational transitions and autofluorescence was confirmed with confocal laser scanning microscopy (CLSM) and two-photon laser scanning microscopy. Poly(styrene-alt-N-maleimide)-based well-defined, stable polyelectrolyte brushes, generating optical signals from conformational changes without conventional fluorophores, may enable the design of sensors and optoelectronic devices.
Synthesis, conformation, and bioactivity of novel analogues of the antiviral lipopeptide halovir A (2006)

We synthesized by solution-phase methods three analogues, [L-Leu(6)-OMe], [L-(alphaMe)Leu(3), L-Leu(6)-OMe], and [L-(alphaMe)Val(4), L-Leu(6)-OMe] of halovir A. The [L-Leu(6)-OMe] analogue is known to be biologically equipotent to its naturally occurring, antiviral, lipopentapeptide amide parent compound. The preferred conformations of the L-(alphaMe)Leu- and L-(alphaMe)Val-containing analogues, with a potentially reinforced helicity, were compared with those of [L-Leu(6)-OMe] halovir A and the natural peptide itself by use of a combination of FT-IR absorption and NMR techniques. Measurements of the antiviral activities against herpes simplex virus type-1 (HSV-1) of halovir A and its three analogues were also carried out. Interestingly, the [L-(alphaMe)Val(4), L-Leu(6)-OMe] analogue exhibits the most significant activity in reducing HSV-1 infectivity, notably higher than that of halovir A itself.
Homeoproteins and the molecular basis of neuronal morphological plasticity (1999)

The co-culturing of embryonic neurons and astrocytes derived from distinct brain regions has demonstrated that neuronal morphology and polarity can be influenced through region-specific neuro-astroglial interactions. In an attempt to search for region-specific factors capable of modulating neuronal morphologies a new strategy has been developed, aimed at antagonizing homeoprotein activity which demonstrated that homeoproteins control the morphological traits of post-mitotic neurons. In the course of the latter experiments we have observed that homeodomains and homeoproteins translocate across biological membranes and gain access to the cytoplasm and nucleus of live cells where they can interfere with the transcriptional activity of endogeneous homeoproteins. We identified the third helix of the homeodomain as the shortest structure necessary and sufficient for internalization and used it to address pharmacological substances inside the cells, in particular peptidic and phosphopeptidic antagonists of distinct signalling pathways. The internalization of full-length homeoproteins led to the investigation of the possibility that homeoproteins are secreted. It was shown that Engrailed gains access to a compartment compatible with secretion in vivo and in vitro and is secreted in vitro, thus possibly acting as a putative polypeptidic messenger. Finally, to further understand the mode of action of homeoproteins, an original gene trap strategy was developed to identify genes in the genetic pathway of homeogenes and we have identified Bullous Pemphigoid Antigen 1 as a candidate Engrailed target. Copyright © 1999 John Wiley & Sons, Ltd.
Photoreactivity Of Epoxy Resins (2007)

Work had been done to establish the photoreactivity of epoxy resins with respect to the chemical structure of their monomers. Two epoxymonomers had been choosen, both having two epoxy functional groups at each terminal ends. The difference between these two epoxy monomers being the length separating the two functional groups called the ÂÂspaceÂÂ group. Results show that the photochemical reactivity is influenced by the chemical structures of monomers, and thus their physical-chemical properties.
Insuficiencia hepática crónica y hemostasia (2017)

La insuficiencia hepática es un estado patológico que condiciona la síntesis y metabolismo de diversas biomoléculas, siendo las alteraciones a la hemostasia una de las primeras consecuencias a nivel sistémico que se hacen presentes; debido a esto y por la dimensión de los riesgos de esta situación, no es raro que las pruebas de coagulación sean indispensables para formular las escalas pronósticas en pacientes hepatópatas.Los conocimientos sobre hemostasia han avanzado en la última década; la clásica cascada de activación de los factores de la coagulación ha sido perfeccionada hasta conformarse el ahora vigente modelo celular que considera la valiosa e indispensable participación del endotelio y las plaquetas. Gracias a esto es posible comprender que, en pacientes con insuficiencia hepática, el riesgo de sangrado no obedece únicamente a la deficiencia en la producción de los factores de la coagulación y, por tanto, es cuestionable la administración de vitamina K. Más relevante aún es que, gracias a estos conocimientos, se puede comprender el a veces contradictorio riesgo de trombosis en estos pacientes, complicación potencialmente mortal.
Two Distinct Plastid Genome Configurations and Unprecedented Intraspecies Length Variation in the accD Coding Region in Medicago truncatula (2014)

We fully sequenced four and partially sequenced six additional plastid genomes of the model legume Medicago truncatula. Three accessions, Jemalong 2HA, Borung and Paraggio, belong to ssp. truncatula, and R108 to ssp. tricycla. We report here that the R108 ptDNA has a ~45-kb inversion compared with the ptDNA in ssp. truncatula, mediated by a short, imperfect repeat. DNA gel blot analyses of seven additional ssp. tricycla accessions detected only one of the two alternative genome arrangements, represented by three and four accessions each. Furthermore, we found a variable number of repeats in the essential accD and ycf1 coding regions. The repeats within accD are recombinationally active, yielding variable-length insertions and deletions in the central part of the coding region. The length of ACCD was distinct in each of the 10 sequenced ecotypes, ranging between 650 and 796 amino acids. The repeats in the ycf1 coding region are also recombinationally active, yielding short indels in 10 regions of the reading frames. Thus, the plastid genome variability we report here could be linked to repeat-mediated genome rearrangements. However, the rate of recombination was sufficiently low, so that no heterogeneity of ptDNA could be observed in populations maintained by single-seed descent.
Organocatalytic Asymmetric Domino Knoevenagel/Diels—Alder Reactions: A Bioorganic Approach to the Diastereospecific and Enantioselective Construction of Highly Substituted Spiro[5,5]undecane‐1,5,9‐triones. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Autonomic Context-Aware Wireless Sensor Networks (2015)

Autonomic Computing allows systems like wireless sensor networks (WSN) to self-manage computing resources in order to extend their autonomy as much as possible. In addition, contextualization tasks can fuse two or more different sensor data into a more meaningful information. Since these tasks usually run in a single centralized context server (e.g., sink node), the massive volume of data generated by the wireless sensors can lead to a huge information overload in such server. Here we propose DAIM, a distributed autonomic inference machine distributed which allows the sensor nodes to do self-management and contextualization tasks based on fuzzy logic. We have evaluated DAIM in a real sensor network taking into account other inference machines. Experimental results illustrate that DAIM is an energy-efficient contextualization method for WSN, reducing 48.8% of the number of messages sent to the context servers while saving 19.5% of the total amount of energy spent in the network.
The Reproducibility of Lists of Differentially Expressed Genes in Microarray Studies (2007)

Abstract Reproducibility is a fundamental requirement in scientific experiments and clinical contexts. Recent publications raise concerns about the reliability of microarray technology because of the apparent lack of agreement between lists of differentially expressed genes (DEGs). In this study we demonstrate that (1) such discordance may stem from ranking and selecting DEGs solely by statistical significance (P) derived from widely used simple t-tests; (2) when fold change (FC) is used as the ranking criterion, the lists become much more reproducible, especially when fewer genes are selected; and (3) the instability of short DEG lists based on P cutoffs is an expected mathematical consequence of the high variability of the t-values. We recommend the use of FC ranking plus a non-stringent P cutoff as a baseline practice in order to generate more reproducible DEG lists. The FC criterion enhances reproducibility while the P criterion balances sensitivity and specificity.
Breast cancer malpractice litigation in New York State. (1993)

Emphasis on early diagnosis has led to the perception that purported delay in diagnosis, however short, even in the presence of a palpable mass, changes the chances for survival.
Fcγ Receptor Cross-linking Stimulates Cell Proliferation of Macrophages via the ERK Pathway (2009)

Macrophage proliferation can be stimulated by phagocytosis and by cross-linking of Fcgamma receptors (FcgammaR). In this study, we investigated the role of FcgammaR and the signaling cascades that link FcgammaR activation to cell cycle progression. This effect was mediated by the activating FcgammaR, including FcgammaRI and III, via their Fcgamma subunit. Further investigation revealed that the cell cycle machinery was activated by FcgammaR cross-linking through downstream signaling events. Specifically, we identified the extracellular signal-regulated kinase (ERK) signaling pathway as a mediator of signals from FcgammaR activation to cyclin D1 expression, because cyclin D1 expression associated with FcgammaR cross-linking was attenuated by specific inhibitors of the ERK1/2 signaling pathway, PD98059 and U0126 and the spleen tyrosine kinase (Syk) inhibitor, Piceatannol. Our findings establish a link between the ERK activation and cell cycle signaling pathways, thus providing a causal mechanism by which FcgammaR activation produces a mitogenic effect that stimulates macrophage proliferation. Macrophage mitosis following FcgammaR activation could potentially affect the outcome of macrophage interactions with intracellular pathogens. In addition, our results suggest the possibility of new treatment options for certain infectious diseases, chronic inflammatory diseases, and leukemias based on interference with FcgammaR-stimulated macrophage cell proliferation.
IL-1β Enhances CD40 Ligand-Mediated Cytokine Secretion by Human Dendritic Cells (DC): A Mechanism for T Cell-Independent DC Activation (2002)

CD40 ligand (CD40L) is a membrane-bound molecule expressed by activated T cells. CD40L potently induces dendritic cell (DC) maturation and IL-12p70 secretion and plays a critical role during T cell priming in the lymph nodes. IFN-gamma and IL-4 are required for CD40L-mediated cytokine secretion, suggesting that T cells are required for optimal CD40L activity. Because CD40L is rapidly up-regulated by non-T cells during inflammation, CD40 stimulation may also be important at the primary infection site. However, a role for T cells at the earliest stages of infection is unclear. The present study demonstrates that the innate immune cell-derived cytokine, IL-1beta, can increase CD40L-induced cytokine secretion by monocyte-derived DC, CD34(+)-derived DC, and peripheral blood DC independently of T cell-derived cytokines. Furthermore, IL-1beta is constitutively produced by monocyte-derived DC and monocytes, and is increased in response to intact Escherichia coli or CD40L, whereas neither CD34(+)-derived DC nor peripheral blood DC produce IL-1beta. Finally, DC activated with CD40L and IL-1beta induce higher levels of IFN-gamma secretion by T cells compared with DC activated with CD40L alone. Therefore, IL-1beta is the first non-T cell-derived cytokine identified that enhances CD40L-mediated activation of DC. The synergy between CD40L and IL-1beta highlights a potent, T cell-independent mechanism for DC activation during the earliest stages of inflammatory responses.
Structure Mechanical Function Relationships of the Fetal Membrane (2007)

A normal pregnancy requires physical integrity of the fetal membrane (FM) until term delivery. Timely rupture of the fetal membrane is a vital part of term labor [1]. Premature failure of the FM, prior to full gestation, accounts for one third of all premature human births and affects 3% of all pregnancies [2]. Membrane rupture is either due to the release of the amniotic fluid, frequently signaling the onset of labor, or under a pathological circumstance [3]. In order to develop a rational basis for treatment and prevention of premature FM failure, we need first to understand FM structural and mechanical behavior. This includes its constituent layers at near full term under normal physiological loading states. Once these properties are established, we can then better formulate how the tissue transitions to the ability to fail at full term.
Beamline for Surface and Interface Structures at SPring-8 (2003)

The main components of a new beamline for surface and interface crystal structure determination at SPring-8 are briefly described. Stages for the beamline monochromator are modified for making an incident X-ray intensity more stable for surface X-ray experiments. Absolute photon flux densities were measured with an incident photon energy. A new ultrahigh vacuum system is introduced with preliminary X-ray measurements from an ordered oxygen on Pt (111) surface.
3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitors Protect Against Oxidized Low-Density Lipoprotein-Induced Endothelial Dysfunction (2003)

Endothelial dysfunction is recognized as an early event in the pathogenesis of atherosclerosis. Many risk factors cause endothelial dysfunction, such as hypercholesterolemia, hypertension, cigarette smoking, and diabetes mellitus. The precise steps leading to endothelial dysfunction are still being elucidated. Increasing evidence indicates that oxidized low-density lipoprotein (LDL) cholesterol (ox-LDL) plays an important role in endothelial dysfunction. Ox-LDL induces endothelial injury; inhibits apoptosis, monocyte adhesion, and platelet aggregation; and inhibits endothelial nitric oxide synthase (eNOS) expression/activity, all of which contribute to atherosclerotic process. Several pharmacologic agents, such as 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins), have been shown to provide endothelial stabilization through mechanisms that go beyond their primary therapeutic effect. Alteration in the endothelial function might result from increase in eNOS activity, reduction in the production of free radicals, inhibition of ox-LDL action, or other undefined mechanisms. This review will focus on the protective role and some of the mechanisms of statins in ox-LDL-induced endothelial dysfunction.
A Comprehensive Review of Power Converter Topologies and Control Methods for Electric Vehicle Fast Charging Applications (2022)

Wide-scale adoption and projected growth of electric vehicles (EVs) necessitate research and development of power electronic converters to achieve high power, low-cost, and reliable charging solutions for the EV battery. This paper presents a comprehensive review of EV off-board chargers that consist of ac-dc and dc-dc power stages from the power network to the EV battery. Although EV chargers are categorized into two types, namely, on-board and off-board chargers, it is essential to utilize off-board chargers for dc fast and ultra-fast charging so that volume and weight of EV can be reduced significantly. Here, we discuss the state-of-the-art topologies and control methods of both ac-dc and dc-dc power stages for off-board chargers, focusing on technical details, ongoing progress, and challenges. In addition, most of the recent multiport EV chargers integrating PV, energy storage, EV, and grid are presented. Moreover, comparative analysis has been carried out for the topologies and the control schemes of ac-dc rectifiers, dc-dc converters, and multiport converters in terms of architecture, power and voltage levels, efficiency, bidirectionality, control variables, advantages, and disadvantages which can be used as a guideline for future research directions in EV charging solutions.
Poliprenolu efekti un to ietekme uz atorvastatīna darbību uzvedības un analgēzijas testos in vivo (2015)

The effect of harvested lymph nodes on the pN stage
Growth and Characterization of p-InGaN/I-InGaN/n-GaN Double Heterojunction Solar Cells on Pattern Sapphire Substrates (2011)

Double heterojunction p-InGaN/i-InGaN/n-GaN solar cells have been fabricated and characterized in this study. Two kinds of sapphire substrate, including conventional sapphire substrate (CSS) and pattern sapphire substrates (PSS), were used for epitaxial growth in this experiment setup. High open-circuit (VOC) of 2.05 V and 2.08 V of double heterojunction InGaN-based solar cell grown on CSS and PSS substrate were demonstrated, respectively. Being difference with solar cell grown on CSS substrate, solar cell grwon on PSS substrate shows an improvement of 27.6% in short-circuit current. Such an improvement can be contributed to the low edge-dislocation density of epitaxial films and the increase of light absorption path due to scattering at patterned surface for solar cell grown on PSS substrate.
Table S3 from Dual Inhibition of IGF-1R and ErbB3 Enhances the Activity of Gemcitabine and Nab-Paclitaxel in Preclinical Models of Pancreatic Cancer (2023)

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Recurrence‐free survival rates after external‐beam radiotherapy for patients with clinical T1–T3 prostate carcinoma in the prostate‐specific antigen era (2004)

The most significant therapeutic factor affecting bRFS rates after RT was radiation dose, rather than AD therapy use or radiation technique.