gebhart/patrepeval huggingface dataset:
Association of Hypoadiponectinemia With Smoking Habit in Men (2005)

Adiponectin is emerging as an important molecule in obesity, the metabolic syndrome, and cardiovascular disease. On the other hand, smoking habit is well known to be related to cardiovascular disease and hypertension. To examine the association between adiponectin concentration and smoking habit, we performed an epidemiological survey and an acute exposure test in humans and an experiment in adipocytes to elucidate the mechanism underlying the association between adiponectin and smoking. In the epidemiological study, we enrolled a total of 331 male subjects to examine chronic smoking exposure. Plasma adiponectin was significantly lower ( P =0.01) in current smokers (5.3±0.3 μg/mL) than in never-smokers (6.5±0.4 μg/mL). A significant association between smoking and low adiponectin level was also confirmed in multiple regression analysis including age, body mass index, hypertension, diabetes, hyperlipidemia, and creatinine clearance (never-smokers 6.5±0.4 μg/mL; past smokers 5.6±0.3 μg/mL; current smokers 5.2±0.4 μg/mL; F =4.52; P =0.01). To examine the acute effect of smoking on adiponectin concentration for 12 hours, we measured plasma adiponectin level in 5 male never-smokers before smoking and 3, 6, and 12 hours after smoking, with the result that adiponectin showed a significant decrease after smoking (12 hours; −14.5±0.6%; P &lt;0.01). In cultured mouse 3T3-L1 adipocytes, H 2 O 2 and nicotine reduced the mRNA expression and secretion of adiponectin in a dose-dependent manner. Smoking habit is associated with adiponectin concentration in men, and its suppressive effect is mediated in part through direct inhibition of smoking on adiponectin expression in adipocytes.
Combustion Parameters Estimation Based on Knock Sensor for Control Purpose Using Dedicated Signal Processing Platform (2008)

&lt;div class="htmlview paragraph"&gt;HCCI or CAI engine technologies require an accurate combustion monitoring and control because there is no direct ignition trigger. The control of ignition is inherently more difficult than in standard internal combustion engines and needs additional sensors such as cylinder pressure to perform closed loop combustion control. In this paper we present a rapid prototyping platform dedicated to high frequency recording and processing. We illustrate the functionalities of the platform through an example of combustion parameters estimation from indirect measurement (knock sensor). The paper ends with a comparison of direct and indirect combustion parameters computation in real time for closed loop combustion control purpose. The presented results are carried out with knock data series recorded on HCCI and CAI engines.&lt;/div&gt;
A Mutant of Parainfluenza Type 1 Virus with Decreased Capacity for Growth at 38 C and 39 C (1970)

Journal Article A Mutant of Parainfluenza Type 1 Virus with Decreased Capacity for Growth at 38 C and 39 C Get access Louis Potash, Louis Potash Search for other works by this author on: Oxford Academic PubMed Google Scholar Ronald S. Lees, Ronald S. Lees Search for other works by this author on: Oxford Academic PubMed Google Scholar Joel L. Greenberger, Joel L. Greenberger Search for other works by this author on: Oxford Academic PubMed Google Scholar Annelise Hoyrup, Annelise Hoyrup Search for other works by this author on: Oxford Academic PubMed Google Scholar Lorraine D. Denney, Lorraine D. Denney Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert M. Chanock Robert M. Chanock Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 121, Issue 6, June 1970, Pages 640–647, https://doi.org/10.1093/infdis/121.6.640 Published: 01 June 1970 Article history Received: 21 January 1970 Revision received: 16 March 1970 Published: 01 June 1970
Chapter 9 Leadership negligence and malpractice: emotional toxicity at SkyWaves Aerospace international (2008)

This chapter presents a case which illustrates how the external management consultant may function as an organizational anthropologist and provide insights and alternative strategies for human resource professionals and leadership faced with high toxicity levels. The long-term failure to timely detect toxins and intervene in a destructive conflict results in the spread of dysfunctional behavior in the case company, pointing to leadership negligence and malpractice. The deeply entrenched “no emotions allowed” culture evokes massive turnover and plunging motivation and productivity. The case concludes with specific recommendations for avoiding or repairing a toxic workplace culture.
THE GREEN HYDRA SYMBIOSIS: ANALYSIS OF A FIELD POPULATION (1987)

Green hydra were abundant on the alga Vaucheria taylorii in a shallow woodland stream near Lincoln, Nebraska, from March to June 1985. Green hydra were also found in low numbers throughout the winter. The algal-animal biomass characteristics of field populations of green hydra are compared to those of cultures established from the field populations and maintained under defined laboratory conditions. Although of similar protein biomass, freshly collected hydra contained greater numbers of symbiotic algae than did cultured hydra. Algae in field hydra were larger and contained more chlorophyll than algae in cultured hydra. Field populations of green hydra were highly productive; 16 µg C·h-1·mg hydra protein-1 were fixed by the endosymbiotic algae at an irradiance of 28 µE·m-2·s-1.
Tumor-induced dysfunction in interleukin-2 production and interleukin-2 receptor signaling: a mechanism of immune escape. (2000)

These findings suggest that soluble products from renal tumors may suppress T-cell responses by blocking both IL-2 production and normal IL-2 receptor signaling.
Structural properties of orexins for activation of their receptors (2005)

The closely related neuropeptides orexin A and orexin B mediate their actions, including the regulation of sleep and appetite, by the activation of the orexin 1 and 2 receptors. To elucidate the structural prerequisites for receptor activation and subtype selectivity, we performed multiple amino acid substitutions within the sequence of orexin A and human orexin B-(6-28)-peptide and analyzed their solution structures by CD spectroscopy and their activity at both receptors in Ca(2+) mobilization assays. For orexin A, we showed that the basic amino acids within the segment of residues 6-14 were important for the activation of both receptors. Furthermore, we showed that the restriction via disulfide bonds is not required to maintain the active structure of orexin A. The kink region of h orexin B has been shown to be important for Ox(2)R selectivity, which is not mediated by the restriction of the turn structure. Additionally, we showed that no particular secondary structure is required for receptor subtype selectivity.
Octreotide (Long-Acting Release Formulation) Treatment in Patients with Graves’ Orbitopathy: Clinical Results of a Four-Month, Randomized, Placebo-Controlled, Double-Blind Study (2005)

There are few effective, safe modalities for the management of Graves' ophthalmopathy (GO), a cell-mediated immune comorbidity of thyroid disease. Somatostatin analogs inhibit lymphocyte proliferation and activation, and accumulate in the orbital tissue of patients with GO. A double-blind, placebo-controlled study of a long-acting somatostatin analog [16 wk of long-acting release formulation of octreotide (octreotide-LAR)] was conducted in 51 patients with mild active GO with the aim of preventing deterioration and precluding the need for more aggressive therapeutic modalities, such as glucocorticoids or radiotherapy. No treatment effect was observed for the primary end point (a composite parameter defining the outcome as either success or failure on the basis of changes in class/grade of the severity index and Clinical Activity Scale of GO). The Clinical Activity Scale score was reduced for patients treated with octreotide-LAR, but without any significant difference with respect to patients receiving placebo. However, octreotide-LAR significantly reduced proptosis (as measured by exophthalmometry). This was associated with nonsignificant differences in favor of octreotide-LAR in a series of proptosis-related parameters: class III grade, opening of the upper eyelid, the difference in ocular pressure between primary position and upgaze, and extraocular muscle involvement. By magnetic resonance imaging evaluation the extraocular muscle volumes appeared reduced, but nonsignificantly. No significant correlation between the initial uptake of the somatostatin analog indium-labeled and the response to treatment was observed. One patient in the octreotide-LAR group developed gallstones. In this study, octreotide-LAR did not seem suitable to mitigate activity in mild GO. Surprisingly, it significantly reduced proptosis, one of the most debilitating symptoms of GO. Additional studies are warranted to define the benefit to risk ratio of the somatostatin analogs in this indication.
LAPAROSCOPIC DRAINAGE OF A POSTTRANSPLANT LYMPHOCELE (1991)

CLAYMAN, RALPH V.; SO, SAMUEL S. K.; JENDRISAK, MARTIN D.; HANTO, DOUGLAS W. Author Information
Inflammatory Bowel Disease in Primary Sclerosing Cholangitis (2013)

IBD in PSC has unique characteristics, and the clinical features of this unique presentation have remained stable over time. A shift in the timing of diagnosis of the 2 diseases has occurred in recent years, with PSC being more often diagnosed first.
Towards Probabilistic Volumetric Reconstruction Using Ray Potentials (2015)

This paper presents a novel probabilistic foundation for volumetric 3D reconstruction. We formulate the problem as inference in a Markov random field, which accurately captures the dependencies between the occupancy and appearance of each voxel, given all input images. Our main contribution is an approximate highly parallelized discrete-continuous inference algorithm to compute the marginal distributions of each voxel's occupancy and appearance. In contrast to the MAP solution, marginals encode the underlying uncertainty and ambiguity in the reconstruction. Moreover, the proposed algorithm allows for a Bayes optimal prediction with respect to a natural reconstruction loss. We compare our method to two state-of-the-art volumetric reconstruction algorithms on three challenging aerial datasets with LIDAR ground truth. Our experiments demonstrate that the proposed algorithm compares favorably in terms of reconstruction accuracy and the ability to expose reconstruction uncertainty.
Coherent phonon oscillations in micelle-suspended single-wall carbon nanotubes (2006)

We report the observation of coherent phonon oscillations of radial breathing modes in insolated single-wall carbon nanotubes in suspension. Resonantly-excited radial breathing modes are analyzed to give us a new tool for chirality assignments, complimentary to photoluminescence and CW Raman spectroscopies.
Impact of endotracheal tube biofilm and respiratory secretions on airway resistance and mechanics of breathing in a neonatal lung model (2018)

Endotracheal tube (ETT) obstruction from biofilm formation is a theoretical risk for intubated preterm neonates. The objective of this study is to determine the impact of ETT biofilm on ETT resistance and minute ventilation in a neonatal respiratory model. Postextubation 2.5- and 3.0-mm ETTs from ventilated preterm infants were matched with unused control ETTs. The pressure gradient across the ETT was measured at set flow rates and converted to airway resistance. Spontaneous breathing tests (SBTs) were performed using a virtual patient model and were considered "passed" if minute ventilation of patient ETTs was greater than 60% of control ETTs. Twenty-four 2.5-mm ETTs and sixteen 3.0-mm ETTs were analyzed. In both patient and control ETTs, as flow rate increases, the pressure gradient across the ETT also increases in a linear fashion. Resistance to flow in patient ETTs was statistically different from matched control ETTs (<i>P</i> < 0.001), and patient ETTs had 19.9 cmH<sub>2</sub>O·l<sup>-1</sup>·sec<sup>-1</sup> greater resistance than control ETTs. SBTs were performed in 27 of 40 ETTs. Twenty-six ETTs "passed" an SBT. In one obstructed 3.0-mm ETT, SBT measurements were unobtainable. The clinical impact of ETT biofilm as measured by a SBT appears to be minimal for the majority of patients in our study group. In 1 out of 27 ETTs, the presence of a biofilm significantly altered resistance to airflow and resulted in a failed SBT. Gas flow rate and ETT size had a greater impact on resistance to airflow and minute ventilation than ETT biofilm in this study sample.<b>NEW & NOTEWORTHY</b> This is the first study to our knowledge to characterize the impact of endotracheal tube (ETT) biofilm and respiratory secretions on resistance to airflow in a neonatal ETT using a simulation neonatal lung model. Results show that the clinical impact of ETT biofilm is minimal for the majority of patients in our study group, and ETT obstruction from biofilm is an uncommon cause of respiratory decompensation in a preterm neonate.
Metal-Ligand Tautomerism, Electron-Transfer, and C(sp3)-H Activation by a 4 Pyridinyl-Pincer Iridium Hydride Complex (2023)

The para-N-pyridyl-based PCP pincer ligand 3,5-bis(di-tert-butylphosphinomethyl)-2,6-dimethylpyridine (pN-tBuPCP-H) was synthesized and metalated to give the iridium complex (pN tBuPCP)IrHCl (2-H). In marked contrast with its phenyl-based congeners (tBuPCP)IrHCl and derivatives, 2-H is highly air sensitive and reacts with oxidants such as ferrocenium, trityl cation, and benzoquinone. These oxidations ultimately lead to intramolecular activation of a phosphino-t-butyl C(sp3)-H bond and cyclometalation. Considering the greater electronegativity of N than C, 2-H is expected to be less easily oxidized than simple PCP derivatives; DFT calculations of direct one-electron oxidations are in good agreement with this expectation. However, 2-H is calculated to undergo metal-ligand-proton tautomerism (MLPT) to give an N-protonated complex that can be described with resonance forms representing a zwitterionic complex (negative charge on Ir) and a p-N-pyridylidene (remote NHC) Ir(I) complex. One-electron oxidation of this tautomer is calculated to be dramatically more favorable than direct oxidation of 2-H (G° = 31.3 kcal/mol). The resulting Ir(II) oxidation product is easily deprotonated to give metalloradical 2• which is observed by NMR spectroscopy. 2• can be further oxidized to give cationic Ir(III) complex, 2+, which can oxidatively add a phosphino-t butyl C-H bond, and undergo deprotonation to give the observed cyclometalated product. DFT calculations indicate that less sterically hindered complexes would preferentially undergo intermolecular addition of C(sp3)-H bonds, for example, of n alkanes. The resulting iridium alkyl complexes could undergo facile -H elimination to afford olefin, thereby completing a catalytic cycle for alkane dehydrogenation that is driven by one-electron oxidation and deprotonation, enabled by MLPT.
A Spatio-Temporal Modeling Approach for Weather Radar Reflectivity Data and Its Applications in Tropical Southeast Asia (2016)

Weather radar echoes, correlated in both space and time, are the most important input data for short-term precipitation forecast. Motivated by real datasets, this paper is concerned with the spatio-temporal modeling of two-dimensional radar reflectivity fields from a sequence of radar images. Under a Lagrangian integration scheme, we model the radar reflectivity data by a spatio-temporal conditional autoregressive process which is driven by two hidden sub-processes. The first sub-process is the dynamic velocity field which determines the motion of the weather system, while the second sub-process governs the growth or decay of the strength of radar reflectivity. The proposed method is demonstrated, and compared with existing methods, using the real radar data collected from the tropical southeast Asia. Note that, since the tropical storms are known to be highly chaotic and extremely difficult to be predicted, we only focus on the modeling of reflectivity data within a short-period of time and consider the short-term prediction problem based on the proposed model. This is often referred to as the nowcasting issue in the meteorology society.
Nonlinear backprojection for tomographic reconstruction (2002)

This paper focuses on a tomographic image reconstruction method, which will be referred to as nonlinear backprojection (NBP). Rather than explicitly statistically modeling the forward process and the unknown image, we train an optimal NBP operator that can be implemented noniteratively. Under appropriate assumptions, the method forms its estimate by applying nonlinear filters to sinogram data, followed by conventional backprojection. The nonlinear filters are designed through off-line training. NBP shows promising results relative to both filtered backprojection and maximum a posteriori probability Bayesian methods.
Thallium solubility range in Tl2 –yBa2Can– 1CunO2n+ 4 –xsuperconductors (1994)

The Tl2 –yBa2Can– 1CunO2n+ 4 –xphases corresponding to n= 1, 2 and 3 have been synthesized at 860–880 °C under sealed-tube conditions and characterized by wet chemical analysis, X-ray diffraction and magnetic susceptibility. A lower Tl solubility limit of (2 –y)= 1.25 was found for all n, but the upper limit decreased from 1.89 for n= 1 to 1.80 for n= 2 and 1.65 for n= 3. Under our controlled synthetic conditions, which allowed variation of the Tl concentration under similar temperatures and oxygen partial pressures, the equilibrium oxygen content was found to vary with the change in Tl concentration so as to keep a constant oxidation of the CuO2 sheets. Over the entire Tl solubility ranges, the superconductive onset temperatures were nearly constant: Ton= 117 ± 1 K for n= 3, Ton= 105 ± 1 K for n= 2, and Ton= 86 ± 1 K for n= 1. The superconductive properties improve sensitively with chemical homogenization, and homogenization was achieved most easily for n= 2. Processing of Tl-2212 superconductors with a controlled Tc under sealed-tube conditions appears to be feasible.
Efficacy of Cyclooctadepsipeptides and Aminophenylamidines against Larval, Immature and Mature Adult Stages of a Parasitologically Characterized Trichurosis Model in Mice (2014)

The genus Trichuris includes parasites of major relevance in veterinary and human medicine. Despite serious economic losses and enormous impact on public health, treatment options against whipworms are very limited. Additionally, there is an obvious lack of appropriately characterized experimental infection models. Therefore, a detailed parasitological characterization of a Trichuris muris isolate was performed in C57BL/10 mice. Subsequently, the in vivo efficacies of the aminophenylamidines amidantel, deacylated amidantel (dAMD) and tribendimidine as well as the cyclooctadepsipeptides emodepside and in particular PF1022A were analyzed. This was performed using various administration routes and treatment schemes targeting histotropic and further developed larval as well as immature and mature adult stages.
Recent progress of ultra-narrow-bandgap polymer donors for NIR-absorbing organic solar cells (2021)

This review provides a comprehensive understanding of the chemical structure and overall development trend for solution-processable NIR-absorbing ultra-narrow-bandgap (UNBG; below 1.5 eV) polymer donors used in organic solar cells.
Activation of HIV-Specific CD8+ T-cells from HIV+ Donors by Vesatolimod (2019)

This study demonstrates that VES treatment can induce the activation of functional HIV-specific CD8<sup>+</sup> T-cells in donor derived PBMCs. These data support the potential use of VES to activate functional HIV-specific CD8<sup>+</sup> T-cells as part of an HIV remission strategy.
Molecular characterization of a 70 kDa heat‐shock protein of bean mitochondria (1993)

A bean cDNA clone that specifies a 70 kDa heat-shock protein (hsp70) has been isolated and sequenced. The nucleotide sequence analysis shows that the cDNA could encode a 72 kDa protein that is highly related to prokaryotic and mitochondrial members of the hsp70 family. The predicted protein was found to contain an amino-terminal extension typical of transit sequences. The in vitro transcription/translation product of the cDNA behaved as a 72 kDa polypeptide as predicted from the longest open reading frame. This polypeptide could be imported into isolated mitochondria and recovered as a 68 kDa product. The imported protein is identical in size to a mitochondrial protein that cross-reacts with hsp70-specific antibodies. The import data and Western blot analysis suggest that the cDNA clone encodes a mitochondrial member of the hsp70 family. Electrophoretic and immunoblot analysis reveal that the protein is loosely associated to the mitochondrial envelope and also exists as discrete soluble protein aggregates of about 270 and 420 kDa. Hsp70 of bean mitochondria can be in vitro phosphorylated on threonine residues in a calcium-dependent manner, and the modified protein was detected as an oligomer of about 160 kDa only. The data are discussed with respect to the chaperone function of hsp70 in mitochondria.
Long Term Animal Experiments With an Intraventricular Axial Flow Blood Pump (1997)

A miniature intraventricular axial flow blood pump (IVAP) is undergoing in vivo evaluation in calves. The IVAP system consists of a miniature (phi 13.9 mm) axial flow pump that resides within the left ventricular (LV) chamber and a brushless DC motor. The pump is fabricated from titanium alloy, and the pump weight is 170 g. It produces a flow rate of over 5 L/min against 100 mmHg pressure at 9,000 rpm with an 8 W total power consumption. The maximum total efficiency exceeds 17%. A purged lip seal system is used in prototype no. 8, and a newly developed "Cool-Seal" (a low temperature mechanical seal) is used in prototype no. 9. In the Cool-Seal system, a large amount of purge flow is introduced behind the seal faces to augment convective heat transfer, keeping the seal face temperature at a low level for prevention of heat denaturation of blood proteins. The Cool-Seal system consumes < 10 cc purge fluid per day and has greatly extended seal life. The pumps were implanted in three calves (26, 30, and 168 days of support). The pump was inserted through a left thoracotomy at the fifth intercostal space. Two pursestring sutures were placed on the LV apex, and the apex was cored with a myocardial punch. The pump was inserted into the LV with the outlet cannula smoothly passing through the aortic valve without any difficulty. Only 5 min elapsed between the time of chest opening and initiation of pumping. Pump function remained stable throughout in all experiments. No cardiac arrhythmias were detected, even at treadmill exercise tests. The plasma free hemoglobin level remained in the acceptable range. Post mortem examination did not reveal any interference between the pump and the mitral apparatus. No major thromboembolism was detected in the vital organs in Cases 1 or 2, but a few small renal infarcts were detected in Case 3.
Direct monitoring of sequential enzymatic hydrolysis of peptides by thermospray mass spectrometry (1984)

A procedure for peptide sequencing using an immobilized exopeptidase column directly coupled to a thermospray mass spectrometer is described. The amino acids sequentially released from the C-terminus of the peptide chain are directly introduced into a thermospray ion source by a flowing aqueous buffer. The buffer is essential for the direct production of ions from solution. The method eliminates the need to derivatize the amino acids for detection and, by comparison to standard injections, amino acid sequence information can be obtained in less than two minutes. With the present configuration, detection limits are typically in the low picomolar range.