gebhart/patrepeval huggingface dataset:
Canadian vaccine research networks: Vaccine safety resources for Canada (2015)

The Public Health Agency of Canada / Canadian Institutes of Health Research Influenza Research Network (PCIRN), established in 2009 to undertake evaluative research to inform public health decision making in Canada, is now being replaced by the Canadian Immunization Research Network (CIRN), which will retain the mandate of PCIRN but expand it to all vaccines including influenza vaccine. CIRN is organized as a network of networks focusing on undertaking research in the areas of vaccine safety, adverse events following immunization (AEFIs), vaccine hesitancy, vaccine effectiveness, and vaccine coverage. CIRN's networks include: a clinical trial network; a laboratory network; a modelling and economics network; a network of social science and humanities researchers; a vaccine safety surveillance network; a hospital-based surveillance network; a clinic network to evaluate serious AEFIs; and a network that links vaccine research capacity in provincial health agencies and departments. PCIRN has contributed to Canada's vaccine safety surveillance system and has facilitated the translation of safety research into policy. Vaccine safety surveillance and research will remain a focus of the newly formed Canadian Immunization Research Network.
Efficient selection of focusing optics in non linear microscopy design trough THG analysis (2004)

A theoretical and experimental study of the THG signal from a reference interface in confocal microscope allows precise analysis of beam propagation and optimization of the focusing objectives.
Proton conductivity in the dry membrane of poly(sulfonic acid) and polyamine layer-by-layer complex (2007)

A layer-by-layer assembled and molecular-complexed polymer membrane was prepared by the simple combination of poly(4-styrenesulfonic acid) and poly(allylamine) on a comb-shaped gold electrode: it displayed a very high proton conductivity of 10(-3) S cm(-1) under a dry condition at 120 degrees C.
A Stochastic Optimization Approach for Cloud Elasticity (2017)

Deployment mechanisms in Cloud environments are becoming more and more attractive to developers that find them easy and convenient to deploy their applications in just few steps. These mechanisms reduced the development cycles from weeks to hours. In this context, elasticity plays an important role in coping with the dynamic nature of these environments. Elasticity mechanisms allow adding or retrieving application instances to deal with the changing number of incoming queries. Determining the optimal number of instances needed in a given horizon is really challenging, since we are dealing with a random number of incoming queries and given that the number of queries fulfilled by a single instance is random as well. Also, there is a trade-off between deploying too many instances and thus paying unnecessary deployment costs and deploying too few of them, and thus paying penalties for not being able to fulfill all in-coming queries on-time. In this paper, we propose a stochastic programming method that determines the optimal number of instances needed in a given planning horizon, putting in mind the uncertain parameters of the problem. In our approach, we learn from the historical behavior of the system to predict the probability distributions of the unknown data, and then formulate a stochastic programming model that optimizes the aforementioned trade-off and outputs the optimal provisioning plan.
Concise Enantioselective Synthesis and Attribution of the Absolute Configuration of Two-Carbon Bridge Methoxylated Cocaines and Pseudococaines (1998)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTConcise Enantioselective Synthesis and Attribution of the Absolute Configuration of Two-Carbon Bridge Methoxylated Cocaines and PseudococainesDaniele Simoni, Marinella Roberti, Vincenza Andrisano, Monica Manferdini, Riccardo Rondanin, and Alan P. KozikowskiView Author Information Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Via Fossato di Mortara 17-19, 44100-Ferrara, Italy, Dipartimento di Scienze Farmaceutiche, Università di Bologna, Italy, and Georgetown Institute of Cognitive and Computational Sciences, 3970 Reservoir Road N.W., Washington, D.C. 20007-2197 Cite this: J. Org. Chem. 1998, 63, 14, 4834–4837Publication Date (Web):June 23, 1998Publication History Received23 February 1998Published online23 June 1998Published inissue 1 July 1998https://pubs.acs.org/doi/10.1021/jo980329rhttps://doi.org/10.1021/jo980329rbrief-reportACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views233Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chromatography,Lipids,Molecular structure,Pharmaceuticals,Reaction products Get e-Alerts
Origins of the enantioselectivity observed in oxazaborolidine-catalyzed reductions of ketones (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrigins of the enantioselectivity observed in oxazaborolidine-catalyzed reductions of ketonesDeborah K. Jones, Dennis C. Liotta, Ichiro Shinkai, and David J. MathreCite this: J. Org. Chem. 1993, 58, 4, 799–801Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/jo00056a001https://doi.org/10.1021/jo00056a001research-articleACS PublicationsRequest reuse permissionsArticle Views1882Altmetric-Citations82LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
3D Fuzzy Graphene Microelectrode Array for Neurotransmitter Sensing at Sub-cellular Spatial Resolution (2020)

Dopamine (DA) is a monoamine neurotransmitter involved in the modulation of various physiological brain functions, including learning, motivation, reward, and motor functions. The development of a high sensitivity real-time sensor for multi-site detection of DA with high spatial resolution has critical implications for both neuroscience and clinical communities to improve understanding and treatments of neurological and neuropsychiatric disorders. Here, we present high-surface area out-of-plane grown three-dimensional (3D) fuzzy graphene (3DFG) microelectrode arrays (MEAs) for highly selective, sensitive, and stable DA electrochemical sensing. 3DFG microelectrodes present a remarkable sensitivity to DA (2.87 ± 0.25 nA/nM, withLOD of 990±15 pM), the highest reported for nanocarbon MEAs using Fast Scan Cyclic Voltammetry (FSCV). The high surface area of 3DFG allows for miniaturization of electrode down to 2 x 2 μm^2, without compromising the electrochemical performance. Moreover, 3DFG MEAs are electrochemically stable under 7.2 million scans of continuous FSCV cycling, present exceptional selectivity over the most common interferents in vitro with minimum fouling by electrochemical byproducts, and can discriminate DA and serotonin (5-HT) in response to the injection of their 50:50 mixture. These results highlight the potential of 3DFG MEAs as a promising platform for FSCV based multi-site detection of DA with high sensitivity, selectivity, and spatial resolution.
Harmonic self‐mode‐locking of optically pumped semiconductor disc laser (2014)

A saturable‐absorber‐free vertical‐external‐cavity surface‐emitting laser is presented which is harmonically modelocked. Modelocking is initiated via fine‐tuning of an aperture which is placed near one of the cavity's end mirrors. Fundamental modelocking is observed along with the second and third harmonic operations for increased optical pump powers. The system features pulse durations penetrating the femtosecond regime at a wavelength of 1014 nm.
Impairment of Fas-antigen expression in adriamycin-resistant but not TNF-resistant MCF7 tumor cells (1996)

Anti-cancer drugs and cytotoxic cytokines such as members of the TNF/Fas-ligand family play a predominant role in apoptosis induction in tumor cells, and are critical in cancer therapy. In this study we used the human breast-carcinoma cell line MCF7, its derivatives MCF7Adr (resistant to adriamycin) and R-A1 (resistant to TNF), to determine the impact of acquired drug and cytokine resistance on susceptibility to Fas-induced cytotoxicity and Fas-antigen expression. While MCF7 and R-A1 cells were killed by anti-Fas in the presence of IFN-gamma, MCF7Adr was found to be resistant to Fas-mediated apoptosis. This resistance was correlated with a loss of surface Fas-protein expression. Fas-gene transfer in MCF7Adr resulted in high sensitivity to Fas-mediated cytotoxicity, indicating that the Fas signalling pathway is virtually intact in this cell line. Over-expression of the MDR1 gene in MCF7 following gene transfer did not affect Fas expression and anti-Fas sensitivity, suggesting that the P-gp-mediated multidrug-resistance phenotype is not directly involved in the loss of Fas expression, contrary to what has been observed by others in T-cell lines. Furthermore, the down-regulation of Fas expression and subsequent resistance to anti-Fas were observed in drug-resistant human ovarian-carcinoma IGR-OV1/VCR cells and leukemic lymphoblast CEM/VLB cells, suggesting that the alteration of Fas expression following drug-resistance selection is not restricted to one cell type.
<title>Heat transfer from magneto-rheological fluid dampers</title> (2000)

This paper presents a theoretical study of heat transfer from magneto-rheological fluid (MRF) dampers. A lumped system model is developed which is capable of predicting the temperature rise for any size MRF damper. As a case study example, finned and unfinned dampers are compared for automotive-size MRF dampers. The results demonstrate that heat transfer from these devices can be enhanced considerably with the use of fins.
Measuring Barrett’s Epithelial Thickness with Volumetric Laser Endomicroscopy as a Biomarker to Guide Treatment (2019)

We developed an algorithm that improves VLE visualization of the mucosal layers of the esophageal wall and enables rapid and reliable measurement of BET. Interobserver variability measurements were significantly reduced when using contrast enhancement. Studies are underway to correlate BET with treatment response.
Event generator tunes obtained from underlying event and multiparton scattering measurements (2016)

New sets of parameters ("tunes") for the underlying-event (UE) modelling of the pythia8, pythia6 and herwig++ Monte Carlo event generators are constructed using different parton distribution functions. Combined fits to CMS UE proton-proton ([Formula: see text]) data at [Formula: see text] and to UE proton-antiproton ([Formula: see text]) data from the CDF experiment at lower [Formula: see text], are used to study the UE models and constrain their parameters, providing thereby improved predictions for proton-proton collisions at 13[Formula: see text]. In addition, it is investigated whether the values of the parameters obtained from fits to UE observables are consistent with the values determined from fitting observables sensitive to double-parton scattering processes. Finally, comparisons are presented of the UE tunes to "minimum bias" (MB) events, multijet, and Drell-Yan ([Formula: see text] lepton-antilepton+jets) observables at 7 and 8[Formula: see text], as well as predictions for MB and UE observables at 13[Formula: see text].
Thermal Evaluation of an Inductive Power Transfer Pad for Charging Electric Vehicles (2021)

In this article, coupled electromagnetic-thermal simulations of inductive power transfer (IPT) pads using finite-element simulations are discussed. Derivation of each electrical and thermal parameters required for the modeling process is outlined. Simulation models are used to predict the power loss and the temperature rise of an IPT pad at different ambient temperatures at steady state. Using these simulation methods, the power loss within an IPT pad operating at 50 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">${^\circ }$</tex-math></inline-formula> C ambient temperature is predicted. A 10-KW IPT system is set up within an environmental chamber to validate the predicted losses within the system.
Characterization of the complete genomic structure of the human versican gene and functional analysis of its promoter (1994)

Versican is a modular proteoglycan involved in the control of cellular growth and differentiation. To understand versican gene regulation and transcriptional control, we have isolated genomic clones spanning the entire gene locus including 5'- and 3'-flanking sequences. Versican was encoded by 15 exons encompassing over 90 kilobase pairs of continuous DNA. The exon organization corresponded to the protein subdomains encoded by homologous proteins, with a remarkable conservation of exon size and intron phase. We discovered an additional exon just proximal to the glycosaminoglycan-binding region that was identical to a recently identified splice variant of versican (Dours-Zimmermann, M.T., and Zimmermann, D.R. (1994) J. Biol. Chem. 269, 32992-32998). The versican promoter harbored a typical TATA box located approximately 16 base pairs upstream of the transcription start site and binding sites for a number of transcription factors involved in regulated gene expression. This promoter was shown to be highly functional in transiently transfected cells of both mesenchymal and epithelial origin. Stepwise 5' deletions identified a strong enhancer element between -209 and -445 base pairs and a strong negative element between -445 and -632 base pairs. This study provides the molecular basis for discerning the transcriptional control of the versican gene and offers the opportunity to investigate genetic disorders linked to this important human gene.
Texaphyrin Conjugates. Progress Towards Second Generation Diagnostic and Therapeutic Agents (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
F3: Beyond the horizon of conventional computing: From deep learning to neuromorphic systems (2017)

This forum brings together experts in software applications, system architectures, and chip designs to explore cognitive computing approaches over the near-, mid-, and long-term.
[The postvagotomy syndrome (author's transl)]. (1977)

The postvagotomy syndrome following the operative section of the vagus nerves is characterized by diarrhoea. The incidence of diarrhoea after truneal vagotomy is about 25%, after selective vagotomy 15% and after proximal selective vagotomy only 2%. The possible pathogenetic factors are accelerated passage through the gut, disturbed bile acid metabolism, the bacterical inflammation of the small intestine, and enterohormonal dysregulation. A cholongenetic diarrhoea is probable because after vagotomy the excretion of bile acids is increased and the diarrhoea is interrupted after administring cholestyramin, which absorbs the bile salts in the intestine. In addition the pathogenetic role of an impaired function of the ileocecal valve should be discussed.
Dispersion Relationship of a Split Ring Re Sonator Metamaterial Arranged in a Circular Waveguide (2020)

We developed a new design of a split ring resonator (SRR) m etamaterial (MTM) structure in a circular waveguide which is similar to a mitron [1] and we calculate its dispersion relatio nship in L-band. We propose two different arrangements of S RRs in the cylinder. One kind is the SRR in a “crab-like” con figuration arranged in the azimuthal direction and the other is a SRR interdigitally arranged in the radial direction in a cyli nder. The period in both arrangements was chosen so as to sat isfy the condition that characterizes MTMs [2]. It is shown t hat when the L-band SRR is interdigitatally arranged in the ra dial direction within a cylinder with radius 2.0 cm and height 6.5 cm, the lowest TM <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">01</inf> mode eigenmode frequency is 1.20 GHz. When the L-band SRR in a “crab-like” is arranged in th e azimuthal direction within a cylinder with a radius 2.0 cm a nd height 6.5 cm, the lowest TE <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</inf> mode eigenmode frequency is 1.45 GHz. This new design of SRRs arranged within a cyli ndrical waveguide can be referenced as a new M-type high p ower microwave generator (HPM) with more compact volume.
Abstract 2241: Possible involvement of glycolipids in anticancer drug resistance of human ovarian serous carcinoma-derived cells. (2013)

Abstract To further characterize the molecular basis on anticancer drug-resistance of human ovarian carcinoma, we compared glycolipid and transporter gene expressions in ovarian serous carcinoma-derived KF28 and 2008 cells with those in their paclitaxel- and cisplatin-resistant cells. Lipid compositions were determined by TLC and TLC-immunostaining and gene expressions of transporter proteins and glycosyltransferases were by RT-PCR. Although the amounts of major lipids, i.e. cholesterol, ceramides and phospholipids, in the resistant cells were same with those in the sensitive cells, Gb3Cer was commonly increased in all resistant cells, irrespective of whether the resistance was to paclitaxel or cisplatin. Also, expressions of the MDR1 gene and gangliosides, GM3 for KF28, and GM1 and GD1a for 2008 cells, were enhanced in paclitaxel-resistant cells, but gangliosides were absent in cisplatin-resistant cells. In accord with the decreased amounts of gangliosides in cisplatin-resistant cells, the gene expression and specific activity of GM3 synthase were greatly decreased in cisplatin-resistant cells. One can suggest that increased amount of Gb3Cer in cisplatin-resistant cells is brought about by the metabolic shifts of LacCer-modifying pathway from GM3- to Gb3Cer-synthases. Furthermore, paclitaxel- and cisplatin-resistant cells were converted to forms more sensitive to the respective anticancer drugs on cultivation with D-PDMP, an inhibitor of GlcCer synthase, and GM3, respectively, prior to the addition of anticancer drugs. Thus, coexpression of the MDR1 gene and glycolipids including gangliosides was thought to be necessary for survival of cells in media containing paclitaxel through regulation of transporter proteins with glycolipids in membrane rafts. Also, the decreased amounts of gangliosides might contribute to the cisplatin resistance, probably by the reduced incorporation of cisplatin. Citation Format: Kyoko Tanaka, Daisuke Aoki, Seiji Isonishi, Mikio Mikami, Kazushige Kiguchi, Masao Iwamori. Possible involvement of glycolipids in anticancer drug resistance of human ovarian serous carcinoma-derived cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2241. doi:10.1158/1538-7445.AM2013-2241
Longitudinal Association of Microaneurysm Wall Characteristics with Perfusion and Local Neuroretinal Pathology (2018)

Although microaneurysms (MAs) are a hallmark lesion of diabetic retinopathy, it is unclear why some MAs result in local neural retinal pathology while others are benign. To address this issue, longitudinal follow-up of MAs with adaptive optics scanning laser ophthalmoscopy (AOSLO) and spectral domain optical coherence tomography (SDOCT) was performed. AOSLO MA images were graded for wall hyperreflectivity (WH), wall deformability (WD), cross-sectional area and perfusion percentage. SDOCT images were graded within a 500μm zone centered on each MA for disorganization of the retinal inner layers (DRIL). Fluorescein angiography evaluated leakage in a subset. A total of 457 MAs of 102 eyes (57 subjects: mean±SD age 44±12 years, DM duration 23#x00B1;10 years, 61% male, 73% type 1 DM) were assessed over 843 visits (154 MAs with ≥1 visit and mean follow-up of 0.52#x00B1;0.35 years). At baseline, MAs with WH were larger (p≤0.0001), less perfused (p≤0.0001), and associated with DRIL (p=0.002). There was a borderline trend for such MAs to leak fluorescein (p=0.05). Over time, MAs with resolved WH had greater likelihood of DRIL improvement. Conversely, MAs that developed WH had more DRIL worsening (p=0.005). WH change vs. stability was associated with decreased perfusion over time (p≤0.0001). At baseline, WD was associated with smaller MAs (p≤0.0001) and increased perfusion (p≤0.0001), but was not related to fluorescein leakage or DRIL. WD resolution and development were associated with decreased and increased perfusion, respectively (p≤0.0001), but not with change in DRIL. These data suggest that whereas WH is a feature of more mature, larger and less perfused MAs associated with local neural pathology, WD may be present in earlier-stage MAs that are smaller and more fully perfused. Future studies will determine whether these parameters can be used to predict changes in MA size, perfusion, leakage or local neural retinal pathology over time. Disclosure J.K. Sun: Other Relationship; Self; Novartis Pharmaceuticals Corporation. Research Support; Self; Genentech, Inc., Optovue, Incorporated, Boston Micromachines Corporation, Adaptive Sensory Technology, Kalvista Pharmaceuticals, Inc.. Other Relationship; Self; Novo Nordisk Inc.. O. Abu-Qamar: None. K. Sampani: None. W. Fickweiler: None. L.P. Aiello: Consultant; Self; Novo Nordisk Inc., Sanofi Genzyme. Stock/Shareholder; Self; Kalvista Pharmaceuticals, Inc.. Consultant; Self; Kalvista Pharmaceuticals, Inc..