gebhart/patrepeval huggingface dataset:
Multimerization Determinants Reside in Both the Catalytic Core and C Terminus of Avian Sarcoma Virus Integrase (1995)

We have shown previously that the active form of avian sarcoma virus integrase (ASV IN) is a multimer. In this report we investigate IN multimerization properties by a variety of methods that include size exclusion chromatography, chemical cross-linking, and protein overlay assays. We show that removal of the nonconserved C-terminal region of IN results in a reduced capacity for multimerization, whereas deletion of the first 38 amino acids has little effect on the oligomeric state. Binding of a full-length IN fusion protein to various IN fragments indicates that sequences in both the catalytic core (residues 50-207) and a C-terminal region (residues 201-240) contribute to IN self-association. We also observe that the isolated C-terminal fragment (residues 201-286) is capable of self-association. Finally, a single amino acid substitution in the core domain (S85G) produces a severe defect in multimerization. We conclude from these analyses that both the catalytic core and a region in the nonconserved C terminus are involved in ASV integrase multimerization. These results enhance our understanding of intergrase self-association determinants and define a major role of the C-terminal region of ASV integrase in this process.
Demonstration of Remote Management and Control in WDM-PON System for 5G Fronthaul (2018)

We successfully demonstrate the OLT protection control and ONU power saving control as remote management and control functions of WDM-PON system for 5G fronthaul application.
Making intersections safer with I2V communication (2018)

Intersections are hazardous places. Threats arise from interactions among pedestrians, bicycles and vehicles, more complicated vehicle trajectories in the absence of lane markings, phases that prevent determining who has the right of way, invisible vehicle approaches, vehicle obstructions, and illegal movements. These challenges are not fully addressed by the "road diet" and road redesign prescribed in Vision Zero plans, nor will they be completely overcome by autonomous vehicles with their many sensors and tireless attention to surroundings. Accidents can also occur because drivers, cyclists and pedestrians do not have the information they need to avoid wrong decisions. In these cases, the missing information can be computed and broadcast by an intelligent intersection. The information gives the current full signal phase, an estimate of the time when the phase will change, and the occupancy of the blind spots of the driver or autonomous vehicle. The paper develops a design of the intelligent intersection, motivated by the analysis of an accident at an intersection in Tempe, AZ, between an automated Uber Volvo and a manual Honda CRV and culminates in a proposal for an intelligent intersection infrastructure. The intelligent intersection also serves as a software-enabled version of the `protected intersection' design to improve the passage of cyclists and pedestrians through an intersection.
Improving On-Device Speaker Verification Using Federated Learning with Privacy (2020)

Information on speaker characteristics can be useful as side information in improving speaker recognition accuracy. However, such information is often private. This paper investigates how privacy-preserving learning can improve a speaker verification system, by enabling the use of privacy-sensitive speaker data to train an auxiliary classification model that predicts vocal characteristics of speakers. In particular, this paper explores the utility achieved by approaches which combine different federated learning and differential privacy mechanisms. These approaches make it possible to train a central model while protecting user privacy, with users' data remaining on their devices. Furthermore, they make learning on a large population of speakers possible, ensuring good coverage of speaker characteristics when training a model. The auxiliary model described here uses features extracted from phrases which trigger a speaker verification system. From these features, the model predicts speaker characteristic labels considered useful as side information. The knowledge of the auxiliary model is distilled into a speaker verification system using multi-task learning, with the side information labels predicted by this auxiliary model being the additional task. This approach results in a 6% relative improvement in equal error rate over a baseline system.
Dramatic osteonecrosis of the jaw associated with oral bisphosphonates, periodontitis, and dental implant removal (2014)

The aim of this report was to discuss the administration period of BP in the treatment of osteoporosis, the decision-making and clinical management of severe MRONJ and the indications for dental implant placement in these specific patients.
Preparation of .alpha., .beta.-unsaturated carboxylic acids and anhydrides (2023)

Disclosed is a process for the preparation of .alpha.,.beta.-unsaturated carboxylic acids and anhydrides thereof which comprises contacting formaldehyde or a source of formaldehyde with a carboxylic anhydride in the presence of a catalyst comprising mixed oxides of vanadium, phosphorus and, optionally, a third component selected from titanium, aluminum or, preferably silicon.
Perturbations in the auxin metabolome participate in the early response of Brassica rapa seedlings to salinity stress (2017)

Salinity is a major abiotic stress affecting Brassica crops. The early salinity stress response in Chinese cabbage seedlings was presented at the physiological and biochemical levels, with particular emphasis on the auxin metabolome. Short-term salinity treatments (24 hours exposure to 50-200 mM NaCl) caused dose- dependent reductions in fresh weight and root growth of seedlings, and increased levels of stress biomarkers (ROS, GSH, proline, Na+/K+ ratio). The physiological and biochemical effects of salinity stress are associated with changes in the levels of stress hormones: ABA and jasmonates (JA and JA-Ile) increased while SA declined upon treatments. Salinity stress modified auxin metabolome, at the biosynthesis of IAA and its catabolism, including irreversible conjugation and oxidation processes. The level of IAA increased gradually with salinity reaching significant increase (1.3 times) at the highest salinity (200 mM NaCl). Salinity stress partially suppresses the IPyA biosynthetic pathway and activates the alternative IAM and IAOx pathways that use IAM and IAN as IAA precursors. Levels of the catabolic IAA metabolite oxIAA increased (1.7- fold) in parallel with those of IAA, and salt stress induced irreversible amino acid conjugation of IAA, leading to a doubling of the concentration of IAA-Asp. Conversely, glucose conjugation was suppressed, causing significant reductions in levels of IAA-Glc and oxIAA-Glc. Further analyses of auxin metabolism in a differently tolerant Brassica species may further illuminate roles of auxins in salinity tolerance in Brassicaceae.
Elemental Behavior during Weathering and Pedogenesis of Clay-Rich Red Soils Developed in Different Lithologies in Java–Madura and Sulawesi in Indonesia (2023)

Clay-rich red soil profiles developed in different lithologies in Indonesia were assessed using geochemical evidence, the migration coefficient and elemental ratios. Our study aimed to ascertain the source of red soil materials and to investigate the elemental behavior in tropical soils. The results indicate carbonate profiles were derived from in situ weathering, while basalt profiles, even though having close affinity to their bedrock, also showed the contribution of external materials. Elemental behavior was dynamic with carbonate profiles indicating relatively constant depletion and even distribution. Basalt profiles indicated uneven distribution with enrichment and depletion. The variation in elemental behavior was linked to difference in lithologies, age and physiochemical conditions. Our findings support evidence of both residual and multiple source parent materials in red soil formation and provide insights into elemental behavior during weathering, while highlighting the influence of external materials’ contribution in deeply weathered tropical soils.
Aligning the Conflicting Needs of Privacy, Malware Detection and Network Protection (2015)

Surveillance is seen as a key tool to detect terrorist activities or to counteract attacks on critical communication infrastructure. Everybody is in those systems to some degree under suspicion. The principle of innocent till proven guilty does not seem to apply to modern surveillance technology usage. On the other hand, criminals would gain easily upper hand in communication networks that are not protected and on the outlook for attacks. This poses quite a problem for the technical implementation and handling of network communication traffic. How can a communication network provider protect user data against malicious activities without screening and loss of the human right of privacy? This article provides a classification system for data usage, privacy sensitivity and risk. With those theoretical tools, we will illustrate on a concrete example how to provide user privacy, while still enable protection against criminals or unauthorized intruders.
The effect of joint stiffness on simulation of the complete gait cycle (2002)

A computer simulation of paraplegic, walker assisted gait through multiple gait cycles is described. Computational problems associated with changing constraints during transitions between phases of gait are avoided by modeling foot-to-floor contact as an external force. Net joint torques, computed from kinematic data by inverse dynamics and transformed into sine functions, are used to drive limb motion. Model instability is overcome by emulating the effects of 'stiffness' at the joints by using proportional-derivative (PD) controllers. Maximum joint torques needed to achieve stable gait were found to be within normal physiological range. Joint kinematics and foot contact forces generally followed a normal gait pattern producing a forward displacement of approximately 0.8 m/s at a walking frequency of 0.5 Hz. The most significant deviation from a normal walking pattern was excessive hip abduction during stance phase causing a waddling (medial-lateral sway) motion. A quantitative measurement of the dynamic stability of the simulation is calculated based on Floquet theory.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Biosensors: Moving from Macro- to Micro- and Nanosensors (2020)

In this review, we consider the trend in the development of biosensors (BSs) that manifests itself in the transition from macro- to micro- and nanodevices. In the successful interaction of biochemical/biotechnological and microelectronic technologies, the use of nanomaterials is accelerating this process. A similar trend is taking place in the development of biofuel elements. Despite the fact that the BS’s dimensions are not subject to accurate quantitative assessment and are not of paramount importance, it is important to pay attention to them when planning the practical application of analytical equipment. The most effective examples are used to illustrate the reduction in the physical size of BSs since their creation in the early 1960s to the present day.
Characteristics and Hole Transporting Properties of Cyclic Oligomers Consisting of 4-Octyltriphenylamine (2022)

Cyclic oligomers including penta-, hexa-, and heptamer (COTPAs-5, 6, and 7, respectively), where 4-octyltriphenylamine units directly links together at 4,4’-positions, were isolated and characterized as hole transporting materials. With the increase of the macrocyclic size, wavelengths of absorption maximum and edge showed red-shift resulting from the increase of effective conjugation length. It is noteworthy that Stokes shift decreased with the size. SCLC hole mobilities in COTPAs-5, 6 and 7 were estimated to be 1.82 × 10-5, 1.20 × 10-4 and 5.11 × 10-5 cm2/Vs, respectively, which was higher than that of linear polymeric analogue (1.67 × 10-6 cm2/Vs).
Cost effectiveness of community pharmacy minor ailment schemes (2010)

This prospective study was undertaken across 5 primary care organisations in northern England in two clusters. Each cluster operated a minor ailment scheme across all community pharmacies. Patients attending were asked 'How did you hear about this minor ailment scheme?' and 'If the scheme were not available, what would you have done?' 1044 patients attended with a minor ailment over a 1-month period across the two clusters. Results showed that patients had become aware of the scheme from their own pharmacy (45.3%), friends or family (24.5%) or the GP practice (10.5%). If the scheme had not existed, most patients would have gone to the GP (46.8%) or bought medicines themselves (44.8%). The scheme cost GBP
4100 for these patients and is estimated to have saved GBP 14,602 over 1 month.
Reactions of vanadium and titanium with molecular hydrogen in krypton and argon matrixes at 12 K (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of vanadium and titanium with molecular hydrogen in krypton and argon matrixes at 12 KZ. L. Xiao, R. H. Hauge, and J. L. MargraveCite this: J. Phys. Chem. 1991, 95, 7, 2696–2700Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April 1991https://pubs.acs.org/doi/10.1021/j100160a015https://doi.org/10.1021/j100160a015research-articleACS PublicationsRequest reuse permissionsArticle Views268Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Molybdenum Solubility in Aluminium Nitrate Solutions (2016)

International audience
A modified form of a tumor-associated phosphorylated peptide derived from BCAR3 generates CD8 T cells that are highly crossreactive to the natural phosphopeptide and capable of recognizing tumor cells (156.13) (2011)

Abstract Using metal ion affinity chromatography and mass spectrometry, we identified a phosphopeptide (BCAR3pT130) derived from BCAR3 among numerous phosphopeptides presented by HLA-A2 on human melanoma cells. BCAR3 activates the PI3K/Akt pathway and mediates migration and estrogen resistance in breast cancer cells, processes that are associated with malignancy. In evaluating the immunotherapeutic use of BCAR3pT130, we found that BCAR3pT130 had a moderate HLA-A2 binding affinity but was nonimmunogenic in HLA-A2 transgenic mice. Substitution of the P9 anchor residue Leu with Val had no impact on HLA-A2 binding affinity but the modified BCAR3pT130 proved to be significantly immunogenic. This suggests that the modification altered the conformation of the phosphopeptide and that the immune response against the natural phosphopeptide is restricted by tolerance. CD8 T cells generated using the modified BCAR3pT130 produced IFNγ, TNFα, and were cytotoxic based on CD107a expression. The T cells were equally reactive with the natural and modified phosphopeptides. This suggests that the natural BCAR3pT130 phosphopeptide is a weak agonist and that the sequence modification creates a stronger agonist. These T cells also recognized endogenously processed BCAR3pT130 on HLA-A2 human melanoma and breast cancer cells. Thus, the association of BCAR3 with malignant processes makes BCAR3pT130 an appealing target for cancer immunotherapy that can be evaluated using the modified form of the phosphoepitope.
A Hierarchical Loss Network Model for Performance Evaluation (2000)

In this paper we present a hierarchical loss network model for estimating the end-to-end blocking probabilities for large networks.As networks grow in size, nodes tend to form clusters geographically and hierarchical routing schemes are more commonly used.Loss network and reduced load models are often used to approximate end-to-end call blocking probabilities and hence throughput.However so far all work beingdone in this area is for at networks with at routing schemes.We aim at developing a more e cient a p p r o ximation method for networks that have a natural hierarchy and or when some form of hierarchical routing policy is used.We present two hierarchical models in detail for xed hierarchical routing and dynamic hierarchical routing policies, respectively, via the notion of network abstraction, route segmentation, tra c segregation and aggregation.Computation is done separately within each cluster local and among clusters global, and the xed point is obtained by iteration between local and global computations.We also present numerical results for the rst case.
Energy Efficient Adiabatic FRAM with 0.99 PJ/Bit Write for IoT Applications (2018)

Low access energy embedded non-volatile memory is critical for low power sensing systems. This paper proposes a charge-recycling FRAM design that uses resonance between the FRAM array capacitance and an off-chip inductor to perform both write and read functions. In 130 nm, the 256×80 FRAM increases energy efficiency by 3× compared to standard operation, achieves 0.99pJ/bit write energy, 0.4pJ/bit read energy and 102Mbps at 1V.
Nonlinearity of Boolean Functions and Hyperelliptic Curves (2003)

We give a novel relationship between the nonlinearity of rational functions over $\mathbb{F}_{2^n}$ and the number of points of the associated hyperelliptic curve. Using this, we obtain a lower bound on the nonlinearity for rational functions over $\mathbb{F}_{2^n}$. Compared to previous work that provides a lower bound on the nonlinearity only for monomials of special types, our result gives a general bound applicable to all rational functions defined over $\mathbb{F}_{2^n}$. By applying this result, we get a lower bound on the nonlinearity for various n × kn S-boxes.
Figure S3 from Integrative Kinome Profiling Identifies mTORC1/2 Inhibition as Treatment Strategy in Ovarian Clear Cell Carcinoma (2023)

&lt;p&gt;Supplementary Figure 3 | Mutation distribution in OCCC. (A) Nonsynonymous mutation distribution in genes involved in the frequently mutated PI3K/AKT/mTOR (blue) and MAPK pathway (yellow), ERBB family of receptor tyrosine kinases (green) and DNA repair (red) pathway is shown. In this OncoPrint, kinome sequenced OCCC tumors are depicted on the horizontal axis and ordered on mutation frequency in the subsequent altered pathways, represented vertically on the right. ARID1A mutant tumors are displayed at the top. (B) BioVenn diagrams demonstrating overlap in ARID1A mutant tumors and PI3K/AKT/mTOR, MAPK and DNA repair pathway and ERBB family of receptor tyrosine kinases mutant tumors (n=103). On the right, PI3K/AKT/mTOR and MAPK pathway, the ERBB family of receptor tyrosine kinases and DNA repair pathway mutations within only ARID1A wildtype tumors (n=49) and only ARID1A mutant tumors (n=44). All data in A and B is derived from 122 kinome-sequenced OCCC tumors, overlap in BioVenn diagram circles is proportional to group overlap.&lt;/p&gt;
Experimental Investigation of Hybrid Beams Utilizing Ultra-High Performance Concrete (UHPC) as Tension Reinforcement (2022)

Ultra-high performance concrete (UHPC) is a new generation concrete with extremely high tensile and compressive strength, high durability, and ductility. UHPC offers tremendous opportunities for use in new thin and slender structural concrete elements and repair of existing concrete structures and has an excellent potential to replace conventional steel reinforcement in normal concrete (NC) members. This paper investigated the potential application of a hybrid NC-UHPC beam using a thin UHPC layer on the tension face to cater to tensile stresses, eliminating the need for passive steel reinforcement. Four-point flexural load tests were performed on 24 composite beams with a thin UHPC layer overlaid with NC. The parameters considered include the thickness of the UHPC layer, depth, and span of the beam. A linear behavior categorizes the flexural behavior of the hybrid NC-UHPC beam up to the ultimate load, after which the hybrid beam shows a non-brittle failure, and softening ensues associated with cracking, increased deflection, and loss of load resisting capacity. The unfinished top surface of the UHPC layer and the overlying NC developed a full composite action without any slip. It was found that a two-day self-curing of the UHPC layer was found to be essential for the development of a strong bond between the layers. The random dispersion and orientation of steel fibers in the UHPC can lead to a decreased tensile response for larger hybrid NC-UHPC beams. The experimental results validate the potential of hybrid NC-UHPC beams as an attractive, structurally feasible, and alternative sound form of construction in terms of their high flexural strength and corrosion-free service life. The proposed unreinforced hybrid system could be used in the construction of precast beams and slabs for residential as well as industrial buildings. Further research, including full-scale load testing of the hybrid beam, is needed prior to practical applications.
Instrumenting a logic programming language to gather provenance from an information extraction application (2012)

Information extraction (IE) programs for the web consume and produce a lot of data. In order to better understand the program output, the developer and user often desire to know the details of how the output was created. Provenance can be used to learn about the creation of the output. We collect fine-grained provenance by leveraging ongoing work in the IE community to write IE programs in a logic programming language. The logic programming language exposes the semantics of the program, allowing us to gather fine-grained provenance during program execution. We discuss a case study using a web-based community information management system, then present results regarding the performance of queries over the provenance data gathered by our logic program interpreter. Our findings show that it is possible to gather useful fine-grained provenance during the execution of a logic based web information extraction program. Additionally, queries over this provenance information can be performed in a reasonable amount of time.
Development of superconducting tunnel junctions for ultra soft X-ray detectors (2001)

Nb-based superconducting tunnel junctions (STJs) with Al trapping layers have been developed for X-ray detectors. One applications for STJs is a low energy radiation detector having energy resolution and a high photon counting rate. STJs have good potential in the band of energies from 40 eV up to 1 keV, because STJs materials have good absorbing properties in this region. The energy resolution was measured by using the Photon Factory beamline BL-12A of High Energy Accelerator Research Organization (KEK) in Japan, and for 200 eV photon, 11 eV Full Width Half at Half Maximum (FWHM) with a 20/spl times/20 /spl mu/m/sup 2/ junction were achieved. In this article, the fabrication technique and preliminary results of measuring the response for this band of energies are reported.