gebhart/patrepeval huggingface dataset:
Primate-specific evolution of noncoding element insertion into PLA2G4C and human preterm birth (2010)

Background The onset of birth in humans, like other apes, differs from non-primate mammals in its endocrine physiology. We hypothesize that higher primate-specific gene evolution may lead to these differences and target genes involved in human preterm birth, an area of global health significance. Methods We performed a comparative genomics screen of highly conserved noncoding elements and identified PLA2G4C, a phospholipase A isoform involved in prostaglandin biosynthesis as human accelerated. To examine whether this gene demonstrating primate-specific evolution was associated with birth timing, we genotyped and analyzed 8 common single nucleotide polymorphisms (SNPs) in PLA2G4C in US Hispanic (n = 73 preterm, 292 control), US White (n = 147 preterm, 157 control) and US Black (n = 79 preterm, 166 control) mothers. Results Detailed structural and phylogenic analysis of PLA2G4C suggested a short genomic element within the gene duplicated from a paralogous highly conserved element on chromosome 1 specifically in primates. SNPs rs8110925 and rs2307276 in US Hispanics and rs11564620 in US Whites were significant after correcting for multiple tests (p < 0.006). Additionally, rs11564620 (Thr360Pro) was associated with increased metabolite levels of the prostaglandin thromboxane in healthy individuals (p = 0.02), suggesting this variant may affect PLA2G4C activity. Conclusions Our findings suggest that variation in PLA2G4C may influence preterm birth risk by increasing levels of prostaglandins, which are known to regulate labor.
Dimensional complexity of the neuronal activity in a rat model of depression (2004)

The Flinders sensitive line of rats is a widely accepted and validated model of depression. These rats demonstrate abnormalities in limbic dopamine neurotransmission, suggesting disturbed neuronal activity in the ventral tegmental area. Interspike interval time-series were recorded from the ventral tegmental area of control Sprague-Dawley and Flinder sensitive line rats. These data were analyzed using standard measures (mean firing rate, bursting activity and spectral analysis) as well as the pointwise correlation dimension, a nonlinear measurement characterizing the complexity degree of dynamic systems. Pointwise correlation dimension, but not standard analysis revealed a significant difference between the animal lines. Our results suggest that nonlinear analyses can detect dysregulation of the mesolimbic dopaminergic system and shed light on the pathophysiology of depression.
Covalent Modification of Synthetic Hydrogels with Bioactive Proteins via Sortase-Mediated Ligation (2015)

Synthetic extracellular matrices are widely used in regenerative medicine and as tools in building in vitro physiological culture models. Synthetic hydrogels display advantageous physical properties, but are challenging to modify with large peptides or proteins. Here, a facile, mild enzymatic postgrafting approach is presented. Sortase-mediated ligation was used to conjugate human epidermal growth factor fused to a GGG ligation motif (GGG-EGF) to poly(ethylene glycol) (PEG) hydrogels containing the sortase LPRTG substrate. The reversibility of the sortase reaction was then exploited to cleave tethered EGF from the hydrogels for analysis. Analyses of the reaction supernatant and the postligation hydrogels showed that the amount of tethered EGF increases with increasing LPRTG in the hydrogel or GGG-EGF in the supernatant. Sortase-tethered EGF was biologically active, as demonstrated by stimulation of DNA synthesis in primary human hepatocytes and endometrial epithelial cells. The simplicity, specificity, and reversibility of sortase-mediated ligation and cleavage reactions make it an attractive approach for modification of hydrogels.
Production and characterization of monoclonal antibodies to Actinobacillus pleuropneumoniae serotype 5b. (1995)

Monoclonal antibodies specific for capsular polysaccharide (CPS) and lipopolysaccharide (LPS) of A. pleuropneumoniae serotype 5b were generated by hybridoma cells and selected by indirect ELISA of culture supernatants with purified and structurally defined LPS and CPS preparations and their synthetic conjugates. It was shown in this study that at least one monoclonal antibody, 3B4, presented 100% specificity and recognized all A. pleuropneumoniae serotype 5 field strains tested in a dot-ELISA assay.
FPGA Control Implementation of a Grid-Connected Current-Controlled Voltage-Source Inverter (2013)

The full control system of a grid-connected current-controlled voltage-source inverter (CC-VSI) has been designed and implemented on a field-programmable gate array (FPGA). Various control functions and implementation methods are described and discussed. The practical viability of the system is evaluated in an experimental setup, where a VSI supplies 30 kW into the local grid at 400 V. A phase-locked loop (PLL) is used for grid phase tracking and evaluated for simulated abnormal grid conditions. Power factor is kept at unity, and the implemented control system is stressed with step responses in the supplied active power. A moving-average filter is implemented to reduce the effects of noise and harmonics on the current control loops. A coupling between active and reactive power flow is observed for the step responses but may be ignored in this context. The proposed system is fully comparable with more conventional microprocessor-based control systems.
Doxorubicin and dexamethasone followed by thalidomide and dexamethasone is an effective well tolerated initial therapy for multiple myeloma (2005)

Among the drug combinations designed for the initial treatment of multiple myeloma, none has been unequivocally shown to be superior. However, a regimen leading to a high response rate and a low incidence of adverse events is highly desirable. We report the results of a phase II clinical trial involving 45 patients with Durie-Salmon stage II and III multiple myeloma. Doxorubicin and dexamethasone were given for 2 or 3 months followed by thalidomide and dexamethasone for 2 months (AD-TD regimen) with prophylactic antibiotics and daily aspirin (81 mg/d). Among the 42 patients whose response could be assessed, 38 responded to therapy (90.5%). The intent-to-treat response rate was 84.4% with seven complete responses (CR 15.5%), nine near complete responses (nCR 20.0%), and 22 partial responses (PR 48.9%). Two patients had stable disease (4.4%), and two progression of disease (4.4%). Normalization of the free light chain ratio after one or two cycles of treatment was highly predictive of achievement of CR or nCR. Patients tolerated the treatment well although five patients developed thromboembolic complications (11%). AD-TD administered with low dose aspirin for deep vein thrombosis prophylaxis was well tolerated and yielded a high response rate with minimal treatment-related morbidity.
Optimization of gain, VSWR and noise of the broadband multistage microwave MMIC amplifier by the real frequency method: synthesis in lumped and distributed elements (2002)

Up to now the simplified real-frequency technique has been applied to the design of broadband multistage microwave amplifiers where gain and voltage standing wave ratio (VSWR) are optimized. In this work, the method is extended to the optimization of the noise figure in parallel with the gain and VSWR. The synthesis of the networks is carried out in two ways, with lumped elements and distributed elements. An ultrawideband GaAs monolithic amplifier, a transimpedance amplifier for optical receivers, and a low-noise ultrawideband amplifier are described as examples of design.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The deep space quantum link: prospective fundamental physics experiments using long-baseline quantum optics (2022)

The National Aeronautics and Space Administration's Deep Space Quantum Link mission concept enables a unique set of science experiments by establishing robust quantum optical links across extremely long baselines. Potential mission configurations include establishing a quantum link between the Lunar Gateway moon-orbiting space station and nodes on or near the Earth. This publication summarizes the principal experimental goals of the Deep Space Quantum Link. These goals, identified through a multi-year design study conducted by the authors, include long-range teleportation, tests of gravitational coupling to quantum states, and advanced tests of quantum nonlocality.
Reversible Charge/Discharge Reaction of a Ternary Metal Fluoride, Pb2CuF6: A Highly Conductive Cathode Material for Fluoride-Ion Batteries (2022)

Fluoride-ion all-solid-state batteries with high energy densities are promising replacements for lithium-ion batteries. Herein, we report Pb2CuF6, which has a fluorite-related structure, as a cathode material for use in fluoride-ion batteries. The Pb2CuF6 cathode composite reacted to charging and discharging without the addition of a solid electrolyte. It exhibited a capacity of 319 mA h cm–3 per electrode volume during the first discharge, exceeding that of the conventional CuF2 electrode. The discharge capacity of Pb2CuF6 remained at 24% of the theoretical capacity, even at 1 mA cm–2 (corresponding to a rate of 0.77C), and the Cu utilization ratio was approximately four times higher than that of a CuF2 cathode. β-PbF2, a fluoride-ion conductor, and metallic Cu were formed during the discharging process of Pb2CuF6; during the subsequent charging process, Pb2CuF6 was formed again. All products of the charge–discharge reaction were present in a nanoparticle form. Pb2CuF6 exhibited an ionic conductivity of 3.0 × 10–5 S cm–1 at 140 °C. The high-rate performance of Pb2CuF6 is attributed to both the high ionic conductivity of the reaction products and the formation of nanoparticles. These findings are beneficial for the material design to improve the charge–discharge performance of electrode materials for fluoride-ion batteries.
Flow Boiling of R134a in Circular Microtubes—Part I: Study of Heat Transfer Characteristics (2011)

An experimental study of two-phase heat transfer coefficients was carried out using R134a in uniformly heated horizontal circular microtubes with diameters from 0.50 mm to 1.60 mm over a range of mass fluxes, heat fluxes, saturation pressures, and vapor qualities. Heat transfer coefficients increased with increasing heat flux and saturation pressure but were independent of mass flux. The effects of vapor quality on heat transfer coefficients were less pronounced and varied depending on the quality. The data were compared with seven flow boiling correlations. None of the correlations predicted the experimental data very well, although they generally predicted the correct trends within limits of experimental error. A correlation was developed, which predicted the heat transfer coefficients with a mean average error of 29%. 80% of the data points were within the ±30% error limit.
Synthesis and in vitro activities of new tryptophan-modified and thiomethylene-containing pseudopeptide antagonists of the neurokinins (2009)

A series of pseudopeptide analogs of the substance P-like hexapeptide Ava-Phe-Phe-Gly-Leu-Met-NH2 was produced by N alpha-protection, introduction of the thiomethylene bond, of D- and non-proteinogenic amino acids, and alteration of the side chain of tryptophan. Synthesis of the pseudopeptides on a solid phase was successfully improved by direct formation of the CH2-S bond on the resin. However, while thiomethylene formation between leucine and norleucine led to the expected SS diastereoisomer, the major product of the similar coupling between two phenylalanines was the SR isomer. An improved resistance of the analogs to proteolysis was observed, which could be related to the structural changes. Interestingly, these modifications led to three water-soluble and potent neurokinin antagonists on classical in vitro bioassays.
Carbon Steel Thin Film Coated Optical Fiber Sensor for Corrosion Monitoring at Elevated Temperature (2020)

Abstract The ability to detect early corrosion onset in real time before structural integrity is compromised can have a significant impact on preventing catastrophic failures of components resulting from corrosion. High durability is required for corrosion sensors in extreme service conditions such as high temperature high pressure in subsurface wellbores. We have previously demonstrated a distributed corrosion sensor for early corrosion detection with the use of proxy materials integrated with the optical fiber sensing platform at ambient conditions. In this work, an optical fiber sensor functionalized with a thin-film coating of carbon steel X65 was tested at 80 °C to study corrosion monitoring capability and sensor durability. The X65 carbon steel thin film was sputter-deposited onto the optical fiber as the corrosion proxy material. The sensor was tested in CO2-saturated and N2-saturated 3.5 wt% NaCl solutions. When exposed to the corrosive solutions, broad-band light absorption of the metallic thin film decreased as the film got thinner; therefore, the light transmission through the optical fiber increased over time. The results demonstrate that X65 thin-film coated optical fiber sensor has successfully detected a higher corrosion rate in the CO2-saturated NaCl solution than that in the N2-saturated NaCl solution at 80 °C.
Facile Synthesis of Furan-3,4-diacetates (1998)

A procedure for bis-cyclopropanation of furans with ethyl diazoacetate or methyl α-diazopropionate under dirhodium-tetraacetate catalysis is presented. Treatment of the products with ethanolic HCl furnished furan-3,4-diacetates.
AIR TO AIR THERMOSYPHON HEAT EXCHANGER FOR CABINET COOLING (2014)

Power electronics devices need active cooling to transfer heat from the enclosure to the ambient and maintain high ingress protection of the enclosure in order to protect the electronics from moisture and various dirt that would reduce its reliability. Air to air heat exchangers are widely used in the industry as they are cost-competitive, easy to install and maintain. On the other hand, they are inefficient and bulky. ABB holds a patent on a cost-effective modular compact thermosyphon based air to air heat exchanger for power electronics cabinet. This technology uses numerous multiport extruded tubes with capillary sized channels disposed in parallel to achieve the desired compactness. The experimental performance of this novel power electronics cooling system with R134a are presented in this paper for a single thermosyphon module. The influence of different parameters such as the heat load, fluid filling ratio, air temperature differences and flow rates were investigated. A numerical model was developed in order to predict the performance of the thermosyphon unit for various and changing operating conditions. Prediction shows good agreement with the experimental results.
GRANNITE: Graph Neural Network Inference for Transferable Power Estimation (2020)

This paper introduces GRANNITE, a GPU-accelerated novel graph neural network (GNN) model for fast, accurate, and transferable vector-based average power estimation. During training, GRANNITE learns how to propagate average toggle rates through combinational logic: a netlist is represented as a graph, register states and unit inputs from RTL simulation are used as features, and combinational gate toggle rates are used as labels. A trained GNN model can then infer average toggle rates on a new workload of interest or new netlists from RTL simulation results in a few seconds. Compared to traditional power analysis using gate-level simulations, GRANNITE achieves >18.7X speedup with an error of only <; 5.5% across a diverse set of benchmark circuits. Compared to a GPU-accelerated conventional probabilistic switching activity estimation approach, GRANNITE achieves much better accuracy (on average 25.9% lower error) at similar runtimes.
Photofragment Imaging of Kr2 and ArKr van der Waals Molecules following Two-Photon Excitation (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotofragment Imaging of Kr2 and ArKr van der Waals Molecules following Two-Photon ExcitationAlbert J. R. Heck, David W. Neyer, Richard N. Zare, and David W. ChandlerCite this: J. Phys. Chem. 1995, 99, 50, 17700–17710Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December 1995https://pubs.acs.org/doi/10.1021/j100050a006https://doi.org/10.1021/j100050a006research-articleACS PublicationsRequest reuse permissionsArticle Views165Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A Monte Carlo simulation study on coarse septa for scatter correction in 3-D PET (2002)

We report the usefulness of coarse septa in positron emission tomography (PET) by Monte Carlo simulation. Coarse septa result in higher sensitivity than found with the two-dimensional mode with conventional full septa and lower scatter fraction than the three-dimensional mode without septa. We propose a new scatter correction method using coarse septa, where scatter components are estimated from coincidence data for those line-of-responses that are intercepted by the coarse septa. This scatter correction potentially has the ability to cope with scatter from radioactivity outside the field of view. In addition, we show the feasibility of a lead tungstate PET scanner with coarse septa.
ChemInform Abstract: Cobalt Metallorganic Chemical Vapor Deposition and Formation of Epitaxial CoSi2 Layer on Si(100) Substrate. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Accuracy and reliability of the endoscopic classification of chronic radiation-induced proctopathy using a novel grading method. (2005)

The RTD grading scale for radiation proctopathy is reproducible among endoscopists. Hematochezia is associated with high RTD grade.
Malware Guard Extension: Using SGX to Conceal Cache Attacks (2017)

In modern computer systems, user processes are isolated from each other by the operating system and the hardware. Additionally, in a cloud scenario it is crucial that the hypervisor isolates tenants from other tenants that are co-located on the same physical machine. However, the hypervisor does not protect tenants against the cloud provider and thus the supplied operating system and hardware. Intel SGX provides a mechanism that addresses this scenario. It aims at protecting user-level software from attacks from other processes, the operating system, and even physical attackers. In this paper, we demonstrate fine-grained software-based side-channel attacks from a malicious SGX enclave targeting co-located enclaves. Our attack is the first malware running on real SGX hardware, abusing SGX protection features to conceal itself. Furthermore, we demonstrate our attack both in a native environment and across multiple Docker containers. We perform a Prime+Probe cache side-channel attack on a co-located SGX enclave running an up-to-date RSA implementation that uses a constant-time multiplication primitive. The attack works although in SGX enclaves there are no timers, no large pages, no physical addresses, and no shared memory. In a semi-synchronous attack, we extract 96% of an RSA private key from a single trace. We extract the full RSA private key in an automated attack from 11 traces within 5 minutes.
EBV‐positive diffuse large B‐cell lymphoma of the elderly: A case series from Peru (2011)

EBV-positive diffuse large B-cell lymphoma (DLBCL) of the elderly is an entity recently included in the WHO classification of lymphoid tumors. We have reviewed our experience and clinical outcomes of this distinct subtype of DLBCL. Between 2002 and 2009, cases of DLBCL were identified from medical records of the Hospital Nacional Edgardo Rebagliati Martins in Lima, Peru, and underwent pathological evaluation including immunohistochemistry for CD20, CD10, bcl-6, MUM1/IRF4, and EBV-encoded RNA in situ hybridization. Clinical data were gathered, tabulated, and reported descriptively. Survival analyses were performed using Kaplan-Meier estimates. Out of 199 cases of DLBCL, 28 cases of EBV-positive DLBCL of the elderly were identified. The median age was 75 years with male predominance (1.5:1). B-symptoms were present in 43%, advanced stage in 50% and International Prognostic Index (IPI) score > 2 in 57% of patients; 68% of patients had a nongerminal center (NGC) phenotype. The complete response rates to R-CHOP and CHOP were 63% and 33%, respectively. The median overall survival (OS) for the group was 5 months. In the univariate analysis, age ≥70 years, lymphocyte count <1.0 × 10(9) /L, and advanced clinical stage were associated with worse OS in patients treated with chemotherapy with and without rituximab. EBV-positive DLBCL of the elderly is a clinically aggressive entity with a short OS and typically presents with advanced stage, high IPI score, and a NGC phenotype. Further studies are needed to investigate if rituximab-containing regimens are associated with better response and OS rates in EBV-positive DLBCL of the elderly.
Translation from Cryptic Reading Frames of DNA Vaccines Generates an Extended Repertoire of Immunogenic, MHC Class I-Restricted Epitopes (2005)

To test whether simple expression units used in DNA vaccines can generate immunogenic, MHC class I-binding epitopes by translating other than the primary open reading frame (ORF), we constructed a vector (pCI/SX) that encodes the small hepatitis B surface Ag in the primary ORF, and a C-terminal fragment (residue 344-832) of the polymerase (Pol) in an alternative (out-of-frame) reading frame. pCI/SX efficiently primed multispecific, HLA-A2-restricted CD8+ T cell responses to epitopes of hepatitis B surface Ag and of Pol (Pol3, Pol(803-811)). Pol3-containing products generated from pCI/SX were detected only by T cell assays, but not by biochemical assays. Priming Pol-specific T cell responses to epitopes generated from alternative ORFs depended on promoter sequences that drive transcription in the DNA vaccine (human CMV-derived promoter sequences being more efficient than SV40-derived promoter sequences). Human CMV promoter-driven Pol constructs encoding different Pol fragments in primary or alternative reading frames elicited comparable levels of Pol3-specific T cell responses. We confirmed efficient T cell priming to epitopes from alternative ORFs by constructing DNA vaccines that encode an SV40-derived cT(1-272) protein fused either in frame or out of frame with an immunogenic OVA fragment (OVA(18-385)). Similar OVA-specific CD8+ T cell responses were primed by both alternative vaccine constructs. Hence, DNA vaccine-stimulated T cell responses to epitopes generated from alternative ORFs seem to be a regular event, although its biological role and risks are largely unexplored.