gebhart/patrepeval huggingface dataset:
Industry harmonization for Unified Standards on Autonomic Management &amp; Control (AMC) of Networks and Services, SDN and NFV (2014)

This paper presents a nutshell view of a White Paper that is being compiled by the various SDOs/Fora for use as an instrument for communicating the recently initiated SDOs/Fora harmonization efforts on standards for the emerging complementary networking paradigms. The joint White-Paper by the collaborating SDOs/Fora covers the subject of Industry Harmonization for Unified Standards on Autonomic Management & Control of Networks and Services, SDN, NFV, and 5G. Readers are encouraged to follow-up and read the joint SDOs/Fora White Paper in order to get more details on the industry efforts and adopt the outcome in research and R&D.
Cachectic Cancer Patients: Immune to Checkpoint Inhibitor Therapy? (2018)

Immune checkpoint inhibition is dramatically improving patient outcomes in diverse cancers, many of which responded poorly to traditional cytotoxic agents. Drivers of heterogeneous response to immune checkpoint therapy are poorly characterized. Cachectic cancer patients exhibit elevated pembrolizumab clearance and poor response, highlighting the immense therapeutic challenge posed by cancer cachexia.<i>See related article by Turner et al., p. 5841</i>.
Regional Cartilage Thinning Occurs First in the Walking Weight Bearing Regions of the Femur in Medial Compartment Knee Osteoarthritis (2008)

Osteoarthritis (OA) of the knee affects an estimated 20–40% of individuals over the age of 65 [1], and is nearly 10 times more common in the medial compartment than the lateral compartment [2]. Plain radiography measurements using the Kellgren and Lawrence (KL) scale have been the gold standard for diagnosis of knee osteoarthritis [3]. However, for new treatment interventions for medial compartment knee OA such as load modifying footwear, it would be important to know if the disease-related cartilage loss in the medial compartment occurs initially and predominantly in regions that are weight bearing during walking. Because walking results in highest weight bearing occurring in the anterior and middle regions of the femoral condyle and the anterior region of the tibial plateau, seeing a pattern of thinning in these areas would suggest that walking is an important activity for understanding both the cause and treatment of osteoarthritis.
Scintillator Light Source for Chemical Sensing in the Near-Ultraviolet (1997)

A novel chemical sensor based on a light source composed of a radionuclide and a scintillator is experimentally evaluated. Proper selection of a radionuclide/scintillator combination permits fabrication of a practical light source emitting in the ultraviolet (UV). Such a UV light source is critical for chemical sensors which utilize UV-excitable chromophores or fluorophores. Unlike conventional gas-filled discharge lamps, the developed UV source is compact, inexpensive, simple in design, stable, and highly reliable, and it does not require an external power source. The utility of the new source was demonstrated through construction of sensors for oxygen. This application was selected for experimental evaluation of the new light source since oxygen sensors have been characterized well with conventional light sources. Although the scintillator light source is less intense than conventional sources, its excellent short- and long-term stability provides a reproducibility of fluorescence measurements of about 0.35% RSD. The stability of the scintillator light source suggests its utility in simple single-beam detection configurations.
The definition of interoperability architectures for intelligent devices using abstract models (2002)

Defining the interoperable interface between clients and end-system devices within a distributed control system has become increasingly more difficult. Because the level of intelligence of the devices has increased, multiple vendor implementations may present widely disparate sets of capabilities and interfaces within a single class of devices. Our solution establishes an architecture that defines a common interface to the superset of capabilities for the device class and that provides well-defined mechanisms for understanding subsets of capabilities. The abstract model approach, which we describe, provides a formal methodology for developing such an interoperability architecture. The abstract model can be used to represent all aspects of the device that pertain to its control by a remote client by defining constructs within the model that represent capabilities and by layering the objects in terms of their capabilities and intelligence, the communications between objects within the model can be identified as candidates for interoperable interfaces. The complete abstract model can then be systematically mapped to a communications protocol to define a complete interoperability architecture.
Feynman-xand transverse-momentum dependence ofD±andD0,D¯0production in 250 GeVπ−-nucleon interactions (1992)

We measure the differential cross section with respect to Feynman-x (${\mathit{x}}_{\mathit{F}}$) and transverse momentum (${\mathit{P}}_{\mathit{T}}$) for charm meson production using targets of Be, Al, Cu, and W. In the range 0.1${\mathit{x}}_{\mathit{F}}$0.7, d\ensuremath{\sigma}/${\mathit{dx}}_{\mathit{F}}$ is well fit by the form (1-${\mathit{x}}_{\mathit{F}}$${)}^{\mathit{n}}$ with n=3.9\ifmmode\pm\else\textpm\fi{}0.3. The difference between n values for ${\mathit{D}}^{\mathrm{\ensuremath{-}}}$ and ${\mathit{D}}^{+}$ is 1.1\ifmmode\pm\else\textpm\fi{}0.7. However, we find an asymmetry of 0.18\ifmmode\pm\else\textpm\fi{}0.06 favoring the production of ${\mathit{D}}^{\mathrm{\ensuremath{-}}}$ compared to ${\mathit{D}}^{+}$. In the lower ${\mathit{P}}_{\mathit{T}}$ range, 2 GeV, d\ensuremath{\sigma}/${\mathit{dP}}_{\mathit{T}}^{2}$ is well fit by the form exp(-b\ifmmode\times\else\texttimes\fi{}${\mathit{P}}_{\mathit{T}}^{2}$) with b=1.03\ifmmode\pm\else\textpm\fi{}0.06 ${\mathrm{GeV}}^{\mathrm{\ensuremath{-}}2}$, while in the higher ${\mathit{P}}_{\mathit{T}}$ range, 0.8 to 3.6 GeV, it is well fit by the form exp(-b'\ifmmode\times\else\texttimes\fi{}${\mathit{P}}_{\mathit{T}}$) with b'=2.76\ifmmode\pm\else\textpm\fi{}0.08 ${\mathrm{GeV}}^{\mathrm{\ensuremath{-}}1}$. The shape of the differential cross section has no significant dependence on atomic mass of the target material.
Asymmetry Compensation by Nonlinear Adaptive Partial Response Equalizer for 31.3 GB Blu-ray Disk ROM (2005)

We investigated a nonlinear adaptive partial response equalizer for the asymmetry compensation of a 31.3 GB higher linear density Blu-ray disc read only memory (ROM) with a 16% asymmetry. A second-order adaptive Volterra filter approximately equalizes a nonlinear signal into a linear one. We reduced its calculation complexity to design a digital circuit in optimum hardware resources by the result of computer simulations. Then we designed an adaptive Volterra filter on an FPGA evaluation board for bit error rate measurements. Finally, we determined that an adaptive Volterra filter has a capability to obtain improved bit error rates by signal linearization in a conventional Viterbi detector for PR(1221).
Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping. (1994)

In an effort to understand the mechanisms by which nonsense codons affect RNA metabolism in mammalian cells, nonsense mutations were generated within the gene for the secretory major urinary protein (MUP) of mice. The translation of MUP mRNA normally begins within exon 1 and terminates within exon 6, the penultimate exon. Through the use of Northern (RNA) blot hybridization and assays that couple reverse transcription and PCR, a nonsense mutation within codon 50 of exon 2 or codon 143 of exon 5 was found to reduce the abundance of fully spliced, nuclear MUP mRNA to 10 to 20% of normal without an additional reduction in the abundance of cytoplasmic mRNA. In contrast, a nonsense mutation within codon 172 of exon 5 was found to have no effects on the abundance of MUP mRNA. These findings suggest that a boundary between nonsense mutations that do and do not reduce the abundance of nuclear mRNA exists within the exon preceding the exon that harbors the normal site of translation termination. In this way, the boundary is analogous to the boundary that exists within the penultimate exon of the human gene for the cytosolic enzyme triosephosphate isomerase. Assays for exon skipping, i.e., the removal of an exon as a part of the flanking introns during the process of splicing, reveal that 0.1, 2.0, and 0.1% of MUP mRNA normally lack exon 5, exon 6, and exons 5 plus 6, respectively. Relative to normal, the two nonsense mutations within exon 5 increase the abundance of RNA lacking exon 5 on average 20-fold and increase the abundance of RNA lacking exons 5 plus 6 on average 5-fold. Since only one of these nonsense mutations also reduces the abundance of fully spliced nuclear mRNA to 10 to 20% of normal, the two mechanisms by which a nonsense mutation can alter nuclear RNA metabolism must be distinct. The analysis of missense mutations within codons 143 and 172, some of which retain the nonsense mutation, indicates that the reduction in the abundance of fully spliced nuclear mRNA is dependent upon the premature termination of MUP mRNA translation, whereas skipping is attributable to nonsense mutation-mediated changes in exon 5 structure rather than to the premature termination of translation. The increase in exon 5 skipping by either the nonsense or missense mutations within codon 172 correlates with a decrease in the complementarity of exon 5 to U1 snRNA. This suggests that a 5' splice site may extend as far as 12 nucleotides into the upstream exon, which is, to our knowledge, the largest extension.
Emerging issues on multimedia distribution (2001)

This session has assembled expertise from both the industry and academia, addressing various interesting issues related to multimedia distribution. Two nicely written and well-covered overviews provide good pointers to readers on security and object-based encoding issues in streaming videos. A. Vetro and H. Sun provide a comprehensive overview of MPEG-4 object-based encoding algorithms which are readily being incorporated in emerging video products and systems. Security, the utmost concern for secured distribution and communications, has been nicely reviewed by E.J. Delp and his colleague. This session also includes two practical applications. S. Wilson and C.H. Chu develop a video system with GPS capability for environmental monitoring. F. Davoli and his colleagues at DIST-University of Genoa, Italy and CNIT, Italian National Telecommunications Consortium, present their LABNET Project, which will enable enhanced multimedia remote device control such as conducting on-line real-time experiments. Finally, H. Liu, N. Ansari and Y.Q. Shi present on-line dynamic bandwidth algorithms that are effective in reducing CLR and improving resource utilization.
Approximate linearization of a synchronous generator by static output feedback: a data-based direct design approach (2002)

Fifth-order models of synchronous machines are not I/O linearizable via static state feedback. Moreover, the measurability of their state is a questionable issue. In this paper it is shown how a 5th-order model of a synchronous machine can be approximately linearized via static output feedback, by resorting to the data-based direct design technique. Such a technique is conceptually simple and relatively cheap from a computational viewpoint.
A Novel Solar PV Inverter Topology Based on an LLC Resonant Converter (2019)

In this paper, a new topology for grid-connected solar PV inverter is proposed. The proposed topology employs an LLC resonant converter with high frequency isolation transformer in the DC-DC stage. The DC-DC converter stage is controlled to generate a rectified sine wave voltage and current at the line frequency. An unfolder inverter interfaces between this DC stage and the grid. Both phase-shift and frequency control methods are used to control the LLC resonant converter. The switching frequency is determined depending on the phase-shift angle to extend the zero-voltage switching (ZVS) region. The transformer leakage and magnetization inductances are also properly designed to provide ZVS for wide operation area. The LLC converter operates in the ZVS region except the narrow band around the zero-crossings of the inverter output current. Since the LLC resonant converter has a high frequency transformer, the line frequency transformer requirement is eliminated, and thus more compact and efficient design is obtained. The proposed topology is validated by the simulation and experimental results.
State Action Separable Reinforcement Learning (2020)

Reinforcement Learning (RL) based methods have seen their paramount successes in solving serial decision-making and control problems in recent years. For conventional RL formulations, Markov Decision Process (MDP) and state-action-value function are the basis for the problem modeling and policy evaluation. However, several challenging issues still remain. Among most cited issues, the inefficiency in utilizing training data is an important factor that causes difficulties in accurately approximating the state-action-value function. We observe that although actions directly define the agents' behaviors, for many problems the next state after a state transition matters more than the action taken, in determining the return of such a state transition. In this regard, we propose a new learning paradigm, State Action Separable Reinforcement Learning (sasRL), wherein the action space is decoupled from the value function learning process for higher learning efficiency. Then, a light-weight transition model is learned to assist the agent to determine the action that triggers the associated state transition. Our convergence analysis reveals that under certain conditions, the convergence time of sasRL is O(T <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1/k</sup> ), where T is the convergence time for updating the value function in the MDP-based formulation and k is a weighting factor. Experiments on several gaming scenarios show that sasRL outperforms state-of-the-art MDP-based RL algorithms by up to 75%.
Evaluation of a chemical library of small-molecule Dishevelled antagonists that suppress tumor growth by down-regulating T-cell factor–mediated transcription (2008)

We describe the rational generation of small-molecule agents that suppress tumor cell growth by down-regulating canonical Wnt signaling. We first produced a chemical library of the derivatives of indole-2-ketones and carbinols; we then screened them by using scalable assays of biochemical antagonism of Dishevelled-1 PDZ domain interactions and cell-based assays of Dishevelled-1-driven T-cell factor-mediated transcription. Compounds showing parallel effects in these assays were tested for selective induction of apoptosis in cancer cells. A new compound (24) that met the criteria for high biochemical antagonism, T-cell factor-mediated transcription, and induction of tumor-selective apoptosis was found to significantly suppress the growth of tumor xenografts in mice.
Edge Charge Neutralization of Clay for Improved Oxygen Gas Barrier in Multilayer Nanobrick Wall Thin Films (2016)

Layer-by-layer (LbL) assembled polymer-clay multilayer thin films are known to provide transparent and flexible gas barrier. In an effort to further lower the oxygen transmission rate (OTR) of these nanobrick wall thin films, sodium chloride was introduced into montmorillonite (MMT) suspension as an "indifferent electrolyte". At pH 6.5 the amphoteric edge sites of MMT have a neutral net charge, and a moderate concentration of NaCl effectively shields the charge from neighboring platelets, allowing van der Waals forces to attract the edges to one another. This edge-to-edge bonding creates a much more tortuous path for diffusing oxygen molecules. An eight-bilayer (BL) polyethylenimine (PEI)/MMT multilayer coating (∼50 nm thick), assembled with 5 mM NaCl in the aqueous clay suspension, exhibited an order of magnitude reduction in oxygen permeability (∼4 × 10<sup>-20</sup> cm<sup>3</sup>·cm/(cm<sup>2</sup>·Pa·s)) relative to its salt-free counterpart. This result represents the best barrier among polymer-clay bilayer systems, which is also lower than SiO<sub>x</sub> or Al<sub>x</sub>O<sub>y</sub> thin films. At higher NaCl concentration, the strong charge screening causes edge-to-face bonding among MMT nanoplatelets, which leads to misalignment in assembled films and increased OTR. This "salty-clay" strategy provides an efficient way to produce better multilayer oxygen barrier thin films by altering ionic strength of the MMT suspension. This simple modification reduces the number of layers necessary for high gas barrier, potentially making these multilayer films interesting for commercial packaging applications.
(Cobaltoceniumylamido)pyridinium hexafluoridophosphate (2021)

The title compound, [Co(C<sub>5</sub>H<sub>5</sub>)(C<sub>10</sub>H<sub>9</sub>N<sub>2</sub>)]PF<sub>6</sub>, was synthesized from deproton-ated 1-amino-pyridinium iodide, followed by microwave-assisted nucleophilic aromatic substitution of iodo-cobaltocenium iodide. After anion exchange with potassium hexa-fluorido-phosphate, the title compound crystallizes as orange prisms in the space group <i>Pc</i>. This very stable pyridine nitrene adduct is the first example of a cobaltocenium derivative, formally containing a nitrene nitro-gen species.
What, Where, and When: Software Fault Localization for SDN (2012)

In this paper we leverage the structure of the SDN software stack to automate the process of troubleshooting networks. We present two techniques for programmatically localizing the root cause of network problems: cross-layer correspondence checking infers what problems exist in the network, and where in the control software the problem first developed; and simulation-based causal inference infers when the triggering event(s) occurred. We evaluated our tools on three popular SDN platforms---Frenetic, Floodlight and POX---and found or reproduced three bugs: isolation breaches and faulty failover logic between replicated controllers.
Identification and Characterization of Proteins That Are Involved in RTP1S-Dependent Transport of Olfactory Receptors (2023)

Olfaction is mediated via olfactory receptors (ORs) that are expressed on the cilia membrane of olfactory sensory neurons in the olfactory epithelium. The functional expression of most ORs requires the assistance of receptor-transporting proteins (RTPs). We examined the interactome of RTP1S and OR via proximity biotinylation. Deubiquitinating protein VCIP135, the F-actin-capping protein sub-unit alpha-2, and insulin-like growth factor 2 mRNA-binding protein 2 were biotinylated via AirID fused with OR, RTP1S-AirID biotinylated heat shock protein A6 (HSPA6), and double-stranded RNA-binding protein Staufen homolog 2 (STAU2). Co-expression of HSPA6 partially enhanced the surface expression of Olfr544. The surface expression of Olfr544 increased by 50-80%. This effect was also observed when RTP1S was co-expressed. Almost identical results were obtained from the co-expression of STAU2. The interactions of HSPA6 and STAU2 with RTP1S were examined using a NanoBit assay. The results show that the RTP1S N-terminus interacted with the C-terminal domain of HSP6A and the N-terminal domain of STAU2. In contrast, OR did not significantly interact with STAU2 and HSPA6. Thus, HSP6A and STAU2 appear to be involved in the process of OR traffic through interaction with RTP1S.
Metal-promoted ligand synthesis, preparation, and characterization of cobalt(II) and -(III) complexes with a highly unsaturated tetraaza macrocyclic ligand (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetal-promoted ligand synthesis, preparation, and characterization of cobalt(II) and -(III) complexes with a highly unsaturated tetraaza macrocyclic ligandA. Martin. Tait and Daryle H. BuschCite this: Inorg. Chem. 1976, 15, 1, 197–203Publication Date (Print):January 1, 1976Publication History Published online1 May 2002Published inissue 1 January 1976https://pubs.acs.org/doi/10.1021/ic50155a041https://doi.org/10.1021/ic50155a041research-articleACS PublicationsRequest reuse permissionsArticle Views186Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
체육분야 국가자격증의 실효성 제고방안 연구(II) : 보건의료분야에서 건강운동관리사의 효율적 활용방안 (2016)

본 연구는 건강운동관리사의 국가자격제도의 활성화를 제고할 수 있는 근거를 마련하고, 건강운동관리사가 보건의료분야에서 효율적으로 활용될 수 있도록 그 근거자료를 제공하는 것을 목적으로 한다. 연구대상자는 총 131명(남자 110명, 여자 21)이었으며, 건강운동관리사 41명, 의사 90명을 임의선정법에 의거 표집 하였다. 건강운동관리사와 의사를 대상으로 별도로 제작된 설문지를 통해 체육분야 국가자격제도의 문제점과 개선안을 조사하였으며, 건강운동관리사 중 10명을 대상으로 FGI를 실시하였다. 연구결과 보건의료 영역에서 건강운동관리사가 효율적으로 활용되기 위해서는 보건/의료 현장 기준의 검정 및 보수교육 시스템을 갖추어야 하며, 안정적인 직업 활동이 가능하도록 국민체육진흥법, 체육시설 설치·이용에 관한법률, 국민건강증진법 등의 관계 법령과 제도가 우선적으로 개선되어야 한다. 아울러 건강운동관리사의 대국민 인지도 및 신뢰도 제고를 위한 장기적인 홍보계획 수립이 시급히 요청된다.
ChemInform Abstract: [1,2]‐Aryl Migration in the Synthesis of Substituted Indoles: Scope, Mechanism, and High Throughput Experimentation. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
IODATE OXIDATION OF N-ACETYL L-CYSTEINE: APPLICATION IN DRUG DETERMINATION AND CHARACTERIZATION OF ITS OXIDATION AND DEGRADATION PRODUCT BY MASS SPECTROMETRY (2014)

A kinetic spectrophotometric method based on the initial rate measurement has been developed for the determination of N-acetyl L-cysteine.The developed method is based on the oxidation of N-acetyl L-cysteine with iodate.The reaction product was studied and characterized using the mass spectrometry and the structure of the product was proposed.From the mass spectrometric studies it was concluded that the oxidation of the drug resulted in the formation of a disulfide.The developed method was validated as per the guidelines of international conference on harmonization.The developed initial rate method was found to be linear in the concentration range of 1.25 -30 µg ml -1 .The detection and quantitation limits were found to be 0.018 and 0.056 µg ml -1 .In the current study, the degradation product of N-acetyl L cysteine was also prepared and identified using mass spectrometry.