gebhart/patrepeval huggingface dataset:
Design and implementation of Abacus switch: a scalable multicast ATM switch (2002)

This paper describes a new architecture for a multicast ATM switch scalable from a few tens to a few thousands of input ports. The switch, called the Abacus switch, has a nonblocking switch fabric followed by small switch modules at the output ports and buffers at input and output ports. A novel algorithm has been proposed to resolve output port contention while achieving input buffer sharing, fairness among the input ports, and call splitting for multicasting. The channel grouping mechanism is also adopted in the switch to reduce the hardware complexity and improve the switch's throughput, while the cell sequence integrity is preserved. A key component for building the Abacus switch, the ATM routing and contention (ARC) chip has been implemented with CMOS 0.8-/spl mu/m technology and tested to operate correctly at 240 Mbit/s. The performance study of the Abacus switch in terms of the throughput, average cell delay, and cell loss rate is also presented.
Serca1 Truncated Proteins Unable to Pump Calcium Reduce the Endoplasmic Reticulum Calcium Concentration and Induce Apoptosis (2001)

By pumping calcium from the cytosol to the ER, sarco/endoplasmic reticulum calcium ATPases (SERCAs) play a major role in the control of calcium signaling. We describe two SERCA1 splice variants (S1Ts) characterized by exon 4 and/or exon 11 splicing, encoding COOH terminally truncated proteins, having only one of the seven calcium-binding residues, and thus unable to pump calcium. As shown by semiquantitative RT-PCR, S1T transcripts are differentially expressed in several adult and fetal human tissues, but not in skeletal muscle and heart. S1T proteins expression was detected by Western blot in nontransfected cell lines. In transiently transfected cells, S1T homodimers were revealed by Western blot using mildly denaturing conditions. S1T proteins were shown, by confocal scanning microscopy, to colocalize with endogenous SERCA2b into the ER membrane. Using ER-targeted aequorin (erAEQ), we have found that S1T proteins reduce ER calcium and reverse elevation of ER calcium loading induced by SERCA1 and SERCA2b. Our results also show that SERCA1 variants increase ER calcium leakage and are consistent with the hypothesis of a cation channel formed by S1T homodimers. Finally, when overexpressed in liver-derived cells, S1T proteins significantly induce apoptosis. These data reveal a further mechanism modulating Ca(2+) accumulation into the ER of nonmuscle cells and highlight the relevance of S1T proteins to the control of apoptosis.
Promoting Civil Discourse Through Search Engine Diversity (2013)

The ability of modern web services such as news aggregators and search engines to tailor their results to the tastes of individuals, together with people's preference for reading opinions which reinforce their own viewpoints, have raised concerns that people are nowadays exposed to a narrow range of view-points, a phenomenon referred to as the “filter bubble”. In this paper we focus on increasing exposure to varied political opinions with a goal of improving civil discourse. We develop a method to algorithmically encourage people to read diverse political opinions and test it when people actively seek information. First, analyzing data from a popular search engine we show that people are indeed more likely to read opinions consistent with their own. Interestingly, they are more likely to read news from opposing sites when the language model of a particular news item is close to the language model of their own political leaning. Based on this finding, we describe a method for assisting people to read divergent opinions by choosing documents of opposing viewpoints that have a language model closer to their own language model. We test our method on a number of web searchers and show that pages of the opposing side which were more similar than the average persons' own language model tended to be clicked 38% more than those below. We also describe the long-term effects of our method, showing that people who were shown more diverse results continued reading more diverse results and overall became more interested in news.
PD-1highCXCR5–CD4+ peripheral helper T cells promote CXCR3+ plasmablasts in human acute viral infection (2023)

T cell-B cell interaction is the key immune response to protect the host from severe viral infection. However, how T cells support B cells to exert protective humoral immunity in humans is not well understood. Here, we use COVID-19 as a model of acute viral infections and analyze CD4<sup>+</sup> T cell subsets associated with plasmablast expansion and clinical outcome. Peripheral helper T cells (Tph cells; denoted as PD-1<sup>high</sup>CXCR5<sup>-</sup>CD4<sup>+</sup> T cells) are significantly increased, as are plasmablasts. Tph cells exhibit "B cell help" signatures and induce plasmablast differentiation in vitro. Interestingly, expanded plasmablasts show increased CXCR3 expression, which is positively correlated with higher frequency of activated Tph cells and better clinical outcome. Mechanistically, Tph cells help B cell differentiation and produce more interferon γ (IFNγ), which induces CXCR3 expression on plasmablasts. These results elucidate a role for Tph cells in regulating protective B cell response during acute viral infection.
Simulation of the Natural Distribution of Carbon and Nutrients in the Ocean Based on the Global Ocean Carbon Cycle Model MOM4_L40 (2015)

Abstract A global ocean carbon cycle circulation model which was developed by the National Climate Center, China Meteorological Administration is presented and the basic performance of this model is analyzed and evaluated in this paper. This model is a global three‐dimensional (3D) ocean carbon cycle circulation model, with 40 layers in vertical direction, and biogeochemical processes developed on the basis of the global ocean circulation model MOM4 (Modular Ocean Model version 4) of the US Geophysical Fluid Dynamics Laboratory (GFDL), which is abbreviated as MOM4_L40 (Modular Ocean Model Version 4 with 40 Levels). This model has been integrated for over 1000 years under climate field forcing. The results indicate that, when compared with the observations, this model can more effectively simulate the surface and vertical distribution characteristics of the ocean temperature, salinity, total carbon dioxide, total alkalinity, and total phosphate levels. The simulated distribution of the total CO 2 in the ocean is basically consistent with observations, of which a low‐value zone exists on the surface, beneath which is a high‐value zone from 10°S to 60°N. However, the simulations above 2000 m are smaller than observations while simulations below 2000 m are larger than observations. In general, the MOM4_L40 model is found to be a reliable tool for the simulation and research of oceanic carbon cycle processes.
1323: Total Corpora Replacement for Erectile Dysfunction (2006)

You have accessJournal of UrologyDiscussed Poster, Tuesday, May 23, 2006, 1:00 - 4:00 pm1 Apr 20061323: Total Corpora Replacement for Erectile Dysfunction Kuo-Liang Chen, James J. Yoo, and Anthony Atala Kuo-Liang ChenKuo-Liang Chen More articles by this author , James J. YooJames J. Yoo More articles by this author , and Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)33536-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1323: Total Corpora Replacement for Erectile Dysfunction." The Journal of Urology, 175(4S), p. 426 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 426 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Kuo-Liang Chen More articles by this author James J. Yoo More articles by this author Anthony Atala More articles by this author Expand All Advertisement PDF downloadLoading ...
Versatile front-end laser system for laser fusion drivers (1993)

We present the design of a novel front end laser system suitable for a laser fusion driver.
DeepTFactor: a deep learning-based tool for the prediction of transcription factors (2020)

The prediction results of DeepTFactor for 73,873,012 protein sequences in 48,346 genomes available from the NCBI Genome database.
Validation of a noninvasive monitor to continuously trend individual responses to hypovolemia (2020)

Background . Humans are able to compensate for significant blood loss with little change in traditional vital signs, limiting early detection and intervention. We hypothesized that the Compensatory Reserve Index (CRI), a new hemodynamic parameter that trends changes in intravascular volume relative to the individual patient’s response to hypovolemia, would accurately trend each subject’s progression from normovolemia to decompensation (systolic blood pressure &lt; 80) and back to normovolemia in humans. Methods . Men and women, ages 19 years to 36 years, underwent stepwise (~333mL aliquot) removal and replacement of 20% blood volume (men, 15 mL/kg; women, 13 mL/kg) via a large bore intravenous (i. v.) line. During each experiment, subjects were monitored with four CipherOx CRI Tablets. Withdrawn blood was reinfused at the end of each experiment. Results . Forty-two subjects (24 men; 18 women) were enrolled in the study, of which 32 completed the protocol. Seven subjects became symptomatic and collapsed (systolic blood pressure &lt; 80), six never achieving maximum blood loss; each was rescued with a saline infusion followed by reinfusion of their stored blood. The mean CRI at baseline for all 42 subjects was 0.9 ± 0.04. The mean CRI for the 32 subjects while asymptomatic at maximum blood loss was 0.611 ± 0.028. For the asymptomatic subjects, the average blood loss volume was 1018 mL ± 286 mL. In comparison, the mean CRI at maximum blood loss for the seven subjects who collapsed was 0.15 ± 0.007 and their average blood loss volume was 860 ± 183 mL. Mean CRI after reinfusion of blood was 0.89 ± 0.02. In addition symptomatic subjects demonstrated three times larger average decrease in CRI per liter of blood removed, 0.85 versus 0.28 for asymptomatic subjects. Conclusion . CRI trends change in intravascular volume relative to an individual’s response to hypovolemia and is sensitive to the differing risks associated with individuals’ differing tolerance to volume loss. (J Trauma Acute Care Surg. 2017;83: S104–S111. DOI: 10.1097/TA.0000000000001511 . Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.) Level of evidence. Prognostic study, level II.
Interactions of Anti-poly[d(G-br 5 C)] IgG with Synthetic, Viral and Cellular Z DNAs (1984)

Enzymatically synthesized poly[d(G-br5C)] was used to prepare specific polyclonal and monoclonal anti-Z DNA IgGs. The binding specificities of these antibodies were characterized using left-handed polynucleotides with the sequences d(G-x5C)n and d(A-x5C)n.d(G-T)n (mean = aza, methyl, bromo, or iodo). Polyclonal anti-poly[d(G-br5C)] IgG binds the convex surface of the Z helix as evidenced by the strong requirement for a methyl or halogen group at the C5 position of cytosine. Little or no anti-poly[d(G-br5C)] IgG binding occurs to left-handed DNAs carrying a phosphorothioate substitution in the dGpdC bond or an N-5 aza substitution in the cytosine ring. Anti-poly[d(G-br5C)] IgG can stabilize transient Z DNA structures in both polymer families, thereby displacing the equilibrium in solution between the right-and left-handed DNA conformations. Anti-poly[d(G-br5C)] IgG binding sites are found in all tested covalently closed circular natural DNAs (Form I) at their extracted negative superhelical densities, but not in any of the corresponding relaxed Form II or linear Form III DNAs. Binding of anti-poly[d(G-br5-C)] IgG leads to a reduction in the electrophoretic mobility of Form I DNA (e.g. SV40, phi X174, or pBR322) and to the formation of dimers comprised of the bivalent antibody and two supercoiled Form I DNA molecules. The dimers are converted to monomers by DTT treatment. The formation of IgG-DNA complexes is dependent on external conditions (ionic strength, temperature), the properties of the DNA (torsional stress, sequence), and the immunoglobulin (specificity, valency, and concentration). Higher order oligomeric species, indicative of two or more left-handed segments per DNA molecule are formed in reactions of anti-poly[d(G-br5C)] IgG with M13 RF I DNA but not with SV40, pBR322, or phi X174 DNAs. However, oligomers of the latter are generated with other anti-Z DNA IgGs having a broader spectrum of anti-Z DNA reactivity. Conditions which destabilize natural Z sequences in deproteinized supercoiled genomes are: monovalent salt concentrations at or above the 'physiological' range, high temperature, and topological relaxation with DNA gyrase (in the absence of ATP) or with type I topoisomerases. DNA gyrase (plus ATP) catalyses an increase in DNA negative superhelical density which leads to greater anti-Z DNA IgG binding, indicating the formation of additional left-handed regions. Polytene chromosomes of insect larvae bind anti-poly[d(G-br5C)] IgG specifically and stably at Z DNA sites. The distribution of this IgG binding differs in certain regions from that displayed by anti-Z DNA IgG probes with other sequence specificities.(ABSTRACT TRUNCATED AT 400 WORDS)
Ritual Networks and Royal Power in Majapahit Java (1996)

Hall Kenneth R. Ritual Networks and Royal Power in Majapahit Java. In: Archipel, volume 52, 1996. pp. 95-118.
Transvenous Left Atrial and Left Ventricular Pacing in Ebstein's Anomaly with Severe Interatrial Conduction Block (2001)

The implantation of permanent pacemakers in patients with congenital heart disease can be challenging. This report describes the complexity of pacemaker implantation in a patient with Ebstein's disease, tricuspid valve replacement, and right atrial abnormalities like severe intra- and interatrial conduction block that prevented dual chamber pacing from conventional sites. This case illustrates the promising possibility to circumvent the interatrial conduction block with single left atrial pacing instead of biatrial pacing which was not suitable here.
Evolution of the IP-over-Optical Core network (2015)

We explore alternative architectures to reduce cost of IP-over-Optical Core networks. We conducted a detailed cost study of three architectures. We start with a Baseline architecture that captures present mode of operations (PMO) with future traffic projections and utilizes technologies such as Ethernet line-cards (LCs) and OTN sub-wavelength switching. The next architecture, Streamlined, replaces the hub-and-spoke topology of Baseline with a flat topology and is also more judicious in its restoration design. Our detailed study shows significant cost savings for the Streamlined architecture compared to the Baseline. We reduce the cost further in our third proposed architecture: Ethernet Enabled IP core (EEIPC) consisting of OTN switches (with and without packet switching) and without any backbone routers or MPLS switches. Our results also demonstrate that we can achieve significant reduction in switching costs but reducing cost of transport remains a significant challenge.
Recognition of ancient eolian longitudinal dunes; a case study in upper Bhander Sandstone, Son Valley, India (1999)

ABSTRACT Straight-crested and internally bipolar cross-stratified eolian dunes are common in the upper part of progradational cycles within the late Proterozoic Upper Bhander Sandstone, Son Valley, India. The Sandstone formed in a coastal setting, and it encompasses supralittoral storm, eolian sand sheet, draa, pond, and ephemeral stream deposits. Ripples of three different size and vector populations typically occur within the dune deposits. The smallest population shows migration parallel to the dune crests, and other two show migration obliquely towards the dune crests. Simple interpolation reveals only 9° deviation of the dune trend from the long-term resultant wind direction. In addition to the two primary wind vectors that control the duneforms, the sand transport ratio less than 1.2 suggests that these are longitudinal dunes. Forward computer modeling and calculation of the maximum gross bedform-normal transport direction further corroborate that the dunes were longitudinal. The dunes are smaller and architecturally simpler than most other longitudinal dunes described in the literature. The methodology adopted here is a useful approach to evaluate longitudinal dunes in the rock record.
Trends in Sensing Side impacts (1989)

&lt;div class="htmlview paragraph"&gt;Timely sensing of side impacts for the purpose of deploying inflatable crash sensing apparatus presents many differences from the problem of frontal crash sensing. These. differences are discussed and some plausible sensing schemes are proposed and reviewed.&lt;/div&gt;
Contact local CD uniformity optimization through etch shrink (2021)

As contact dimensions continue to shrink to support scaling, local CD variation (LCDU) becomes a critical driver of electrical variation and defectivity. Continued logic scaling is highly dependent on middle of line (MOL), which further amplifies the need for LCDU improvement. LCDU improvement will be critical to improving edge placement error (EPE). The same concepts can also be applied to back end of line (BEOL) vias. Since lithography tools are unable to consistently print contacts below 20 nm, it is typically necessary to shrink through etch. There are various etch techniques we can use to shrink contact dimensions each having different impacts on LCDU and defectivity. In this study we explore the impacts of various shrink methods to optimize LCDU and defect density. In this study a simple patterning stack of SiN + OPL + ARC + resist is used to simulate contact patterning. Various etch chambers and shrink techniques are used to reach a target CD range and LCDU and defect density are evaluated. The chambers evaluated include TEL’s conductor etcher and TEL’s dielectric etcher. LCDU data is collected using CDSEM. Defect density is evaluated using various etch techniques. Etch techniques such as deposition on resist, ARC and OPL, descum steps, pulsing and quasi atomic layer etch are explored. Multiple types of deposition techniques are used including selective deposition and cyclic deposition and trim. These techniques are optimized to be sensitive to open area and correct for local CD variations. On wafer LCDU performance of &lt;2.0nm is demonstrated and further optimization is done to minimize defectivity.
Multi-Scale Self-Attention for Text Classification (2020)

In this paper, we introduce the prior knowledge, multi-scale structure, into self-attention modules. We propose a Multi-Scale Transformer which uses multi-scale multi-head self-attention to capture features from different scales. Based on the linguistic perspective and the analysis of pre-trained Transformer (BERT) on a huge corpus, we further design a strategy to control the scale distribution for each layer. Results of three different kinds of tasks (21 datasets) show our Multi-Scale Transformer outperforms the standard Transformer consistently and significantly on small and moderate size datasets.
THE EFFECT OF BOVINE EPHEMERAL FEVER VIRUS ON THE BOVINE FOETUS (1975)

Six pregnant heifers that were experimentally infected with bovine ephemeral fever virus produced normal calves. Foetuses of 8 heifers that were immune to bovine ephemeral fever were inoculated with bovine ephemeral fever virus. One was aborted after 36 days, but the cause of abortion could not be determined. One was sacrificed after 28 days. The foetus and its membranes were normal and neither virus nor antibody was demonstrated. The other 6 heifers produced normal calves. One calf, 501, inoculated after 160 days gestation, contained high levels of neutralising antibody in serum before ingestion of colostrum. The others, inoculated at gestational ages of 52 days to 157 days showed no evidence of neutralising antibody in blood samples collected at birth.
Mechanism of localized electrical conduction at the onset of electroforming in TiO2 based resistive switching devices (2014)

The onset of localized current conduction during electroforming of TiO2-based resistive switching devices is investigated using a pulsed voltage method. The temperature rise at electroforming onset is found to vary from 25 to 300 °C as the pulse amplitude and the width are varied between 3–8 V and 10 ns–100 ms, respectively. The effective activation energy of the forming event is strongly electric field dependent and decreases from 0.7 eV at 3 V to almost zero at 8 V. The functional form of this dependence points toward charge trapping as the mechanism rather than oxygen vacancy motion.
Explant analysis of Utah electrode arrays implanted in human cortex for brain-computer-interfaces (2021)

Abstract Brain-computer interfaces are being developed to restore movement for people living with paralysis due to injury or disease. Although the therapeutic potential is great, long-term stability of the interface is critical for widespread clinical implementation. While many factors can affect recording and stimulation performance including electrode material stability and host tissue reaction, these factors have not been investigated in human implants. In this clinical study, we sought to characterize the material integrity and biological tissue encapsulation via explant analysis in an effort to identify factors that influence electrophysiological performance. We examined a total of six Utah arrays explanted from two human participants involved in intracortical BCI studies. Two Pt arrays were implanted for 980 days in one participant (P1) and two Pt and two iridium oxide (IrOx) arrays were implanted for 182 days in the second participant (P2). We observed that the recording quality followed a similar trend in all 6 arrays with an initial increase in peak-to-peak voltage during the first 30-40 days and gradual decline thereafter in P1. Using optical and two-photon microscopy (TPM) we observed a higher degree of tissue encapsulation on both arrays implanted for longer durations in participant P1. We then used scanning electron microscopy and energy dispersive X-ray spectroscopy to assess material degradation. All measures of material degradation for the Pt arrays were found to be more prominent in the participant with a longer implantation time. Two IrOx arrays were subjected to brief survey stimulations, and one of these arrays showed loss of iridium from majority of the stimulated sites. Recording performance appeared to be unaffected by this loss of iridium, suggesting that the adhesion of IrOx coating may have been compromised by the stimulation, but the metal layer did not detach until or after array removal. In summary, both tissue encapsulation and material degradation were more pronounced in the arrays that were implanted for a longer duration. Additionally, these arrays also had lower signal amplitude and impedance. New biomaterial strategies that minimize fibrotic encapsulation and enhance material stability should be developed to achieve high quality recording and stimulation for longer implantation periods.
ChemInform Abstract: Antitumor Activity of Brasilicardin A, a Novel Terpenoid Antibiotic from Nocardia brasiliensis. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.