gebhart/patrepeval huggingface dataset:
Ameliorating hydroxychloroquine induced retinal toxicity through cerium oxide nanoparticle treatments (2021)

The present study investigated the potential protective effects of cerium oxide nanoparticles (CNP) on human retinal pigment epithelium (ARPE-19) cells damaged by hydroxychloroquine (HCQ). Toxicity of HCQ on the ARPE-19 cells was explored with a dose response trial. CNP rescue both a pre-treatment protocol, where CNP were applied 24 hours prior to HCQ application and a simultaneous treatment protocol where both CNP and HCQ were applied together, were used. In the dose response trial, 250 µM HCQ showed 51.84% cell viability after 24 hours and 32.75% after 48 hours time period. This was selected as model HCQ dose for rescue trials. The simultaneous treatment trials did not show a significant increase in viability compared to model toxic dose. The CNP pre-treatment trials showed a significant increase in cellular viability compared to model toxic dose with 68.03% ± 3.27 viability (p = 4.56E-05) at 24 hours and 51.85% ± 4.96 (p = 1.18E-05) at 48 hours time period. CNP pre-treatment showed significant protection of cells from HCQ induced toxicity. The difference in efficacy of simultaneous and pre-treatment is hypothesized to lie in the cellular localization of CNP. Furthermore, including the reactive oxygen species (ROS) scavenging properties of CNP seems to be responsible for protection, the effect of CNP on autophagosome and lysosome colocalization are also hypothesized to play a significant role.
Supplementary Figure Legends from Discovery and Characterization of Novel Mutant FLT3 Kinase Inhibitors (2023)

Supplementary Figure Legends from Discovery and Characterization of Novel Mutant FLT3 Kinase Inhibitors
ChemInform Abstract: ABSOLUTE RATES OF TRIPLET‐TRIPLET DIMERIZATION AND CYCLOADDITION OF TRIMETHYLENEMETHANE BIRADICALS (1977)

Abstract Die Bestrahlung einer Lösung des Diazens (I) in einem 2:1‐ Gemisch aus Isopropanol und Propanol bei l43,5°K führt in einer Reaktion 2. Ordnung zum Diradikal (II) und dessen Dimeren.
Large area transferred silicon nanomembrane photonic devices on unconventional substrates (2013)

Silicon microelectronics on unconventional substrates has led to numerous unprecedented applications. Inspired by the great success, it is a natural desire to integrate silicon photonic circuitry on unconventional substrates in the hope of extending the applicability range of silicon photonics to a multitude of novel hybrid silicon photonic devices. However, photonic devices usually have larger dimensions and more complicated morphologies. The transfer method used in electronics cannot be applied directly to transfer photonic devices. Here, we propose a low temperature transfer technique based on adhesive bonding and deep reactive ion etching. A defect-free transfer of 2 cm &times; 2 cm, 250 nm thick silicon nanomembrane onto a glass slide has been demonstrated. Single mode waveguides and splitters fabricated on the transferred SiNM exhibit comparable results to those fabricated on silicon-on-insulator. With a low process temperature, this method can be easily applied to transfer silicon nanomembranes onto various types of substrates.
Search for new phenomena in a lepton plus high jet multiplicity final state with the ATLAS experiment using s = 13 $$ \sqrt{s}=13 $$ TeV proton-proton collision data (2017)

A search for new phenomena in final states characterized by high jet multiplicity, an isolated lepton (electron or muon) and either zero or at least three b-tagged jets is presented. The search uses 36.1 fb -1 of s = 13 TeV proton-proton collision data collected by the ATLAS experiment at the Large Hadron Collider in 2015 and 2016. The dominant sources of background are estimated using parameterized extrapolations, based on observables at medium jet multiplicity, to predict the b-tagged jet multiplicity distribution at the higher jet multiplicities used in the search. No significant excess over the Standard Model expectation is observed and 95% confidence-level limits are extracted constraining four simplified models of R-parity-violating supersymmetry that feature either gluino or top-squark pair production. The exclusion limits reach as high as 2.1 TeV in gluino mass and 1.2 TeV in top-squark mass in the models considered. In addition, an upper limit is set on the cross-section for Standard Model t tt t production of 60 fb (6.5 the Standard Model prediction) at 95% confidence level. Finally, model-independent limits are set on the contribution from new phenomena to the signal-region yields.
Review of adverse reactions to injections of Chinese materia medica (2010)

Using Chinese Materia Medica (CM) as injections is an innovation that is proving effective in extensive clinical use in Mainland China. However, recent reports have focused on adverse reactions, ignoring the considerable successes of these preparations. In order to achieve balance in the media and in the minds of the public, we suggest the first step is to clarify the concepts of and differences between adverse drug reactions (ADR) and adverse events (AE) for all concerned-the public, medical practitioners, government officials, and lawmakers. Second, the State Food and Drug Administration should raise the requirements for Chinese Materia Medica Injection (CMI) registration and license approval and emphasize the importance of evidence-based CMI development and evidence-based CMI license approval. Thirdly, drug companies and institutions should reinforce basic research about the quality control of herbs and CMI-drug interactions. Fourth, the Government should clarify the legal responsibilities for CMI approval agencies, CMI developers, medical doctors, and patients. Fifth, the medical association and Government should enhance training for health care professionals concerning the usage of CMIs. And finally sixth, State Food and Drug Administration should monitor the content and quality of the directions for use of CMI.
Quasi-maximum-likelihood multiple-symbol differential detection for time-varying Rayleigh fading channel (2009)

The maximum-likelihood multiple-symbol differential detector (ML-MSDD) has better bit-error-rate performance than many other detectors for differential modulation. Unfortunately, the computational complexity of ML-MSDD quickly becomes prohibitive as the observation window size grows. While low-complexity MSDD algorithms for the time-invariant Rayleigh fading channel have been considered before, there is a need for low-complexity MSDD algorithms for general time-varying Rayleigh fading channels. A polynomial-time complexity approach called semi-definite relaxation (SDR) is employed to achieve differential detection with near maximum-likelihood (ML) performance. The proposed SDR quasi-maximum-likelihood (QML) multiple-symbol differential detection (SDR-QML-MSDD) is efficient in that its complexity is polynomial in the observation window size, even in the worst case, while it exhibits almost the same performance as ML-MSDD does.
Deuteration of Non-Stabilized Phosphorus Ylides With DMSO-d6: Convenient Synthesis of Mono-Deuterated Alkenes (1983)

Abstract The use of DMSO-d6 as a solvent or cosolvent in the Wittig reaction results in the incorporation of deuterium into the phosphorus ylide and the alkene product.
Early combined immunosuppression may be effective and safe in older patients with Crohn’s disease: post hoc analysis of REACT (2019)

We observed no difference in efficacy and safety of early combined immunosuppression compared to conventional management in older and younger patients. Early combined immunosuppression may be considered as a treatment option in selected older patients with Crohn's disease with suboptimal disease control. Clinical Trial Identifier: NCT01030809.
Feed-Forward Frequency Domain Equalizer for Fast SOP Transient Tracking in Coherent Optical Modems (2023)

We propose a feed-forward frequency domain adaptive linear equalizer that can track fast state-of-polarization (SOP) transients in the fiber. In the proposed method, we rely on the pilot symbols that are inserted into the DSP frame to estimate the channel response and then compensate for it. Unlike the decision-directed least mean squares (DD-LMS) algorithm, the proposed circuit is designed in a feed-forward fashion and avoids the latencies involved in DD-LMS feedback loop in order to achieve the best possible SOP tracking capabilities. The proposed algorithm is shown to be robust against high order differential group delay (DGD) and polarization dependent loss (PDL) and offers a significant tracking improvement compared to DD-LMS.
Sterol compositions and susceptibilities to amphotericin B of environmental Cryptococcus neoformans isolates are changed by murine passage (1995)

Previous studies have shown that sequential isolates from patients with persistent Cryptococcus neoformans meningoencephalitis can vary in sterol composition and susceptibility to antifungal drugs. To investigate the potential of host factors as mediators of this phenomenon, we compared fungal susceptibilities of environmental and clinical isolates from a limited geographic area. Clinical isolates were less susceptible to amphotericin B than environmental isolates. Five environmental isolates were passaged through BALB/c murine hosts; the passaged isolates had changes in sterol composition and reduced amphotericin B susceptibilities relative to those of the parent isolates. In contrast, murine passage of these isolates did not alter their susceptibilities to fluconazole. The results confirm that changes in sterol composition and antifungal susceptibility can occur in vivo as a result of host factors and suggest that human infection can result in selection of variants with reduced susceptibilities to amphotericin B.
Immunoassay and antibody microarray analysis of the HUPO Plasma Proteome Project reference specimens: Systematic variation between sample types and calibration of mass spectrometry data (2006)

This chapter contains sections titled: Introduction Materials and methods Reference specimens DB immunoassays Antibody arrays at GNF Antibodies, reagents, microarray printing, and platform Microarray layout and processing Array imaging and data analysis Antibody microarrays at MSI Chip manufacture Rolling circle amplification (RCA) immunoassay Conversion of mean fluorescent intensity to concentration Antibody microarrays at VARI Fabrication of antibody microarrays Serum labeling Processing of antibody microarrays Analysis Retrieval and matching of IPI numbers for the analytes Results Antibody-based measurements of the HUPO reference specimens Systematic variation between the preparation methods of the PPP reference specimens Consistent alterations in specific protein abundances Linkage of MS data and antibody-based measurements Discussion References
Design automation with mixtures of proof strategies for propositional logic (2003)

Design automation problems can often be encoded in propositional logic, and solved by applying propositional logic proof methods. Unfortunately, there exists no single proof method with adequate performance for all problems of interest. It is, therefore, critical to be able to combine different approaches, and to quickly be able to test how different compositions affect overall performance. In this paper, we present a proof engine framework where individual methods are viewed as strategies-functions between different proof states. By defining our proof engine in such a way that we can compose strategies to form new, more powerful, strategies we achieve synergistic effects between the individual methods. Unlike previous approaches, our framework is flexible enough to allow users to quickly come up with specially tailored composite analyses for problems from any of the different subdomains of design automation. We show how several known analyses for solving design automation problems encoded in propositional logic can be integrated as base strategies in our framework. As a proof-of-concept, and to demonstrate the power inherent in the framework, we also present experimental results that show the performance of two default composite strategies that we have developed using the framework over a period of several years. These strategies are often one to two magnitudes faster when compared with binary decision diagram-based techniques and search-based satisfiability solvers such as ZCHAFF. The introduction of the framework was the key facilitator in the development of these default strategies.
Macrophage-HIV interaction (1990)

Viral isolates were recovered by cocultivation on macrophage colony-stimulatingfactor (MCSF)-treated monocyte target cells from peripheral blood mononuclear cells (PBMCs) in 25 out of 27 patients seropositive or at risk for HIV infection. Frequency of virus recovery was independent of the patient's age, sex, numbers of CD4+ T cells, clinical stage or zidovudine (azidothymidine) therapy. Sixteen out of 19 HIV isolates were serially passaged in MCSF- treated monocytes. Five out of five virus isolates were also passaged in phytohemagglutinin/interleukin-2 (PHA/IL-2)-treated lymphoblasts. In lymphoblasts, no qualitative or quantitative differences were observed between these isolates and human T-cell leukemia virus IIIB (HTLV-IIIB) for (1) release of p24 antigen reverse transcriptase, and infectious virus, (2) induction of typical cytopathic effects (cell syncytia in 3-10% of cells) and cell lysis, (3) frequency of infected cells (5-20% of PBMC) as detected by in situ hybridization for HIV RNA, (4) down-modulation of T cell plasma membrane CD4, and (5) site of progeny virion assembly and budding (plasma membrane only with no intracytoplasmic accumulation of virus). Progeny virus recovered from infected lymphoblasts was fully infectious for other lymphoblasts, but failed to infect MCSF-treated monocytes. Detailed analysis of target cell tropism among HIV isolates showed that HIV isolated in monocytes infected both monocytes and lymphoblasts; progeny virus isolated in lymphoblasts infected only T cells. HIV interacts differently with monocytes and T cells. Understanding this interaction may more clearly define both the pathogenesis of HIV disease and strategies for therapeutic intervention.
The Utility of Preoperative Magnetic Resonance Imaging for Determining the Flexibility of Sagittal Imbalance (2017)

MRI adequately determined which sagittal deformities were flexible. Furthermore, with flexible sagittal deformities, lumbar lordosis measured on MRI more accurately predicted the intraoperative lumbar lordosis than that measured on standing X-ray. The ability to preoperatively predict intraoperative lumbar lordosis with positioning helps with surgical planning and patient counseling regarding expectations and risks of surgery.
Massive MIMO: ten myths and one critical question (2016)

Wireless communications is one of the most successful technologies in modern years, given that an exponential growth rate in wireless traffic has been sustained for over a century (known as Cooper’s law). This trend will certainly continue, driven by new innovative applications; for example, augmented reality and the Internet of Things. Massive MIMO has been identified as a key technology to handle orders of magnitude more data traffic. Despite the attention it is receiving from the communication community, we have personally witnessed that Massive MIMO is subject to several widespread misunderstandings, as epitomized by following (fictional) abstract: “The Massive MIMO technology uses a nearly infinite number of high-quality antennas at the base stations. By having at least an order of magnitude more antennas than active terminals, one can exploit asymptotic behaviors that some special kinds of wireless channels have. This technology looks great at first sight, but unfortunately the signal processing complexity is off the charts and the antenna arrays would be so huge that it can only be implemented in millimeter-wave bands.” These statements are, in fact, completely false. In this overview article, we identify 10 myths and explain why they are not true. We also ask a question that is critical for the practical adoption of the technology and which will require intense future research activities to answer properly. We provide references to key technical papers that support our claims, while a further list of related overview and technical papers can be found at the Massive MIMO Info Point: http://massivemimo. eu
The Irish Potato Famine Pathogen Phytophthora infestans Translocates the CRN8 Kinase into Host Plant Cells (2012)

Phytopathogenic oomycetes, such as Phytophthora infestans, secrete an arsenal of effector proteins that modulate plant innate immunity to enable infection. We describe CRN8, a host-translocated effector of P. infestans that has kinase activity in planta. CRN8 is a modular protein of the CRN effector family. The C-terminus of CRN8 localizes to the host nucleus and triggers cell death when the protein is expressed in planta. Cell death induction by CRN8 is dependent on its localization to the plant nucleus, which requires a functional nuclear localization signal (NLS). The C-terminal sequence of CRN8 has similarity to a serine/threonine RD kinase domain. We demonstrated that CRN8 is a functional RD kinase and that its auto-phosphorylation is dependent on an intact catalytic site. Co-immunoprecipitation experiments revealed that CRN8 forms a dimer or multimer. Heterologous expression of CRN8 in planta resulted in enhanced virulence by P. infestans. In contrast, in planta expression of the dominant-negative CRN8(R469A;D470A) resulted in reduced P. infestans infection, further implicating CRN8 in virulence. Overall, our results indicate that similar to animal parasites, plant pathogens also translocate biochemically active kinase effectors inside host cells.
Mice Genetically Deficient in Vasopressin V1a and V1b Receptors Are Resistant to Jet Lag (2013)

Jet-lag symptoms arise from temporal misalignment between the internal circadian clock and external solar time. We found that circadian rhythms of behavior (locomotor activity), clock gene expression, and body temperature immediately reentrained to phase-shifted light-dark cycles in mice lacking vasopressin receptors V1a and V1b (V1a(-/-)V1b(-/-)). Nevertheless, the behavior of V1a(-/-)V1b(-/-) mice was still coupled to the internal clock, which oscillated normally under standard conditions. Experiments with suprachiasmatic nucleus (SCN) slices in culture suggested that interneuronal communication mediated by V1a and V1b confers on the SCN an intrinsic resistance to external perturbation. Pharmacological blockade of V1a and V1b in the SCN of wild-type mice resulted in accelerated recovery from jet lag, which highlights the potential of vasopressin signaling as a therapeutic target for management of circadian rhythm misalignment, such as jet lag and shift work.
Impact of Velocity and Interfacial Tension on the Performance of Horizontal Wells in Gas Condensate Reservoirs (2010)

Drilling horizontal wells (HWs) has recently received renewed attentions with the increasing trend in exploitation of tight gas reservoirs. An accurate estimation of productivity of such systems using a numerical simulator is a challenging task, because its 3D simulation requires a fine grid exercise to capture the abrupt variation of fluid and flow parameters around the wellbore. This is cumbersome and impractical for field applications. In this work, Comsol mathematical package has been used to simulate 3D two-phase flow around a gas condensate HW under steady-state conditions. The model accounts for phase and composition changes and dependency of relative permeability to velocity and interfacial tension (IFT). The integrity of the model was verified by comparing some of its results with those obtained using fine grid option of a commercial compositional simulator under the same flow conditions. A sensitivity study of the impact of pertinent parameters on the HW performance was conducted with some important practical findings. The results demonstrated that for a given pressure drawdown, an increase in velocity or decrease in IFT improves HW performance at lower HW lengths, whilst the negative impact of high velocity inertial flow is more pronounced at higher total gas fractional flow rate (GTR), smaller wellbore radius and higher reservoir thickness values. Theses results also indicated that the rock properties could influence the productivity (the HW to vertical well flow rates) ratio significantly.
Continuous chiral separations in microreactors (2016)

The potential of microreactors for enantioselective liquid-liquid extraction has been explored. The experiments were performed in capillary microreactors with combined reactive extraction and phase separation, for the chiral separation of a representative racemic amino acid derivative (3,5-R,S-DNBLeu) dissolved in water by using a chiral host (a chinchona alkaloid) in the organic phase (1-octanol or 1,2-DCE). The results show that the ee is higher at short residence times of the two liquid phases in comparison with the ee at equilibrium. The performance and advantages of microreator operation in chiral separation will be further discussed.
Definition and diagnosis of cerebral palsy in genetic studies: a systematic review (2020)

Limited compliance with international consensus guidelines on phenotypic definition and mediocre reporting of CP case ascertainment hinders the comparison of results among genetic studies of CP (including meta-analyses), thereby limiting the quality, interpretability, and generalizability of study findings. Compliance with the SCPE guidelines is important for ongoing gene discovery efforts in CP, given the potential for misclassification of unrelated neurological conditions as CP.
Tyrosine phosphorylation of rasGAP and associated proteins in chronic myelogenous leukemia cell lines (1992)

Abstract The Philadelphia chromosome (Ph1), detected in virtually all cases of chronic myelogenous leukemia, is formed by a reciprocal translocation between chromosomes 9 and 22 that fuses BCR encoded sequences upstream of exon 2 of c-ABL. This oncogene produces a fusion protein (p210BCR/ABL) in which the ABL tyrosine kinase activity is elevated. This elevated kinase activity is essential for transformation, but the mechanisms involved are unknown. We report here that p21ras GTPase activating protein (rasGAP) or rasGAP-associated proteins p190 and p62 are phosphorylated on tyrosine in Ph1 (+) cell lines. Further, rasGAP coimmunoprecipitates with p210BCR/ABL in these cell lines. These results suggest that rasGAP or associated proteins are potential substrates for p210BCR/ABL kinase and thus directly link p210BCR/ABL with a signal transduction pathway known to be activated by hematopoietic growth factors (p21ras).
GAPVD1 and ANKFY1 Mutations Implicate RAB5 Regulation in Nephrotic Syndrome (2018)

Mutations in <i>GAPVD1</i> and probably in <i>ANKFY1</i> are novel monogenic causes of NS. The discovery of these genes implicates RAB5 regulation in the pathogenesis of human NS.
CENTRAL HEMODYNAMIC MONITORING IN OPEN VERSUS CLOSED CHEST CONDITIONS: IS THERE A DIFFERENCE? (2004)

SOCIETY OF CRITICAL CARE MEDICINE 34TH CRITICAL CARE CONGRESS PHOENIX, ARIZONA, USA JANUARY 15-19, 2005: Poster Presentation: Clinical Science: Cardiovascular Disease or Dysfunction (Adult) II