gebhart/patrepeval huggingface dataset:
Performance of a Hybrid TDD-CDMA System with Random Slot Allocation (RSA) in Comparison with an Equivalent FDD-CDMA System (2005)

This paper proposes a hybrid form of ad-hoc networking where the public network frequency and technology is re-used to establish an ad-hoc network. The proposed technology is TD-CDMA, which will be used for both public and ad-hoc in the same frequency band. In particular, this paper treats the performance difference between a hybrid public & ad-hoc TDDCDMA system employing random slot assignment, an equivalent TDD-CDMA system without any extra ad-hoc interference and an equivalent FDD-CDMA system. It will be shown that the additional interference on the hybrid system caused by the private ad-hoc network is minimal. Furthermore, it will be demonstrated that the performance of the hybrid TDD system outperforms the FDD mode.
Germline Mutation of RPS20, Encoding a Ribosomal Protein, Causes Predisposition to Hereditary Nonpolyposis Colorectal Carcinoma Without DNA Mismatch Repair Deficiency (2014)

Little is known about the genetic factors that contribute to familial colorectal cancer type X (FCCX), characterized by hereditary nonpolyposis colorectal carcinoma with no mismatch repair defects. Genetic linkage analysis, exome sequencing, tumor studies, and functional investigations of 4 generations of a FCCX family led to the identification of a truncating germline mutation in RPS20, which encodes a component (S20) of the small ribosomal subunit and is a new colon cancer predisposition gene. The mutation was associated with a defect in pre-ribosomal RNA maturation. Our findings show that mutations in a gene encoding a ribosomal protein can predispose individuals to microsatellite-stable colon cancer. Evaluation of additional FCCX families for mutations in RPS20 and other ribosome-associated genes is warranted.
Aggregability of Red Blood Cells of Schizophrenia Patients With Negative Syndrome Is Selectively Enhanced (2004)

Schizophrenia patients can be categorized into positive and negative syndromes (PS and NS) by the behavioral criteria of the Positive and Negative Syndrome Scale (PANSS), but these symptoms can also be evaluated as a continuous trait. Both types exhibit cerebral microcirculatory disorders, which are ameliorated by drug treatment in PS but not in NS patients. Red blood cell (RBC) aggregability plays a major role in the microcirculation. Previously reported changes in RBC membrane phospholipid composition indicate a difference in aggregability between RBCs of NS and PS patients. In this study the aggregability of PS RBCs and NS RBCs was analyzed using a computerized cell flow-properties analyzer, as a physiological marker of NS and PS. Results showed that while the aggregability of PS RBCs was normal, that of NS RBCs was markedly enhanced and strongly correlated with the NS score. The results exhibited stability and reproducibility over 1 to 8 weeks test-retest and were independent of gender, age at testing and onset of illness, fibrinogen levels, smoking, and current medication. NS RBCs have constitutively elevated aggregability, which can contribute to cerebral microcirculatory disorders and may be a biological marker for distinguishing between PS and NS in genetic studies of schizophrenia.
Identification of ciliary neurotrophic factor receptor α as a mediator of neurotoxicity induced by α‐synuclein (2010)

This article was originally published in Proteomics 2010, 10 , 2138–2150, DOI 10.1002/pmic.200900745
Use of relative code churn measures to predict system defect density (2005)

Software systems evolve over time due to changes in requirements, optimization of code, fixes for security and reliability bugs etc. Code churn, which measures the changes made to a component over a period of time, quantifies the extent of this change. We present a technique for early prediction of system defect density using a set of relative code churn measures that relate the amount of churn to other variables such as component size and the temporal extent of churn.Using statistical regression models, we show that while absolute measures of code churn are poor predictors of defect density, our set of relative measures of code churn is highly predictive of defect density. A case study performed on Windows Server 2003 indicates the validity of the relative code churn measures as early indicators of system defect density. Furthermore, our code churn metric suite is able to discriminate between fault and not fault-prone binaries with an accuracy of 89.0 percent.
Scalable and Interpretable Product Recommendations via Overlapping Co-Clustering (2017)

We consider the problem of generating interpretable recommendations by identifying overlapping co-clusters of clients and products, based only on positive or implicit feedback. Our approach is applicable on very large datasets because it exhibits almost linear complexity in the input examples and the number of co-clusters. We show, both on real industrial data and on publicly available datasets, that the recommendation accuracy of our algorithm is competitive to that of state-of-art matrix factorization techniques. In addition, our technique has the advantage of offering recommendations that are textually and visually interpretable. Finally, we examine how to implement our technique efficiently on Graphical Processing Units (GPUs).
Evidence of molecular heterogeneity for generalised glycogenosis between and within breeds of cattle (1995)

Northern analyses revealed normal levels of acidic alpha-glucosidase mRNA in cultured fibroblasts from a Shorthorn calf affected with glycogenosis but a gross deficiency in an affected Brahman calf. Analyses of acidic alpha-glucosidase activity, relative to that of other lysosomal enzymes, in blood mononuclear cells revealed greater variation within and between Brahman herds than Shorthorn herds. A Msp1 restriction fragment length polymorphism associated with glycogenosis in Brahmans was not found in Shorthorns. These results are considered in relation to molecular heterogeneity for AAG deficiency in cattle and its implications for disease control programs.
Who Goes First? Influences of Human-AI Workflow on Decision Making in Clinical Imaging (2022)

Details of the designs and mechanisms in support of human-AI collaboration must be considered in the real-world fielding of AI technologies. A critical aspect of interaction design for AI-assisted human decision making are policies about the display and sequencing of AI inferences within larger decision-making workflows. We have a poor understanding of the influences of making AI inferences available before versus after human review of a diagnostic task at hand. We explore the effects of providing AI assistance at the start of a diagnostic session in radiology versus after the radiologist has made a provisional decision. We conducted a user study where 19 veterinary radiologists identified radiographic findings present in patients' X-ray images, with the aid of an AI tool. We employed two workflow configurations to analyze (i) anchoring effects, (ii) human-AI team diagnostic performance and agreement, (iii) time spent and confidence in decision making, and (iv) perceived usefulness of the AI. We found that participants who are asked to register provisional responses in advance of reviewing AI inferences are less likely to agree with the AI regardless of whether the advice is accurate and, in instances of disagreement with the AI, are less likely to seek the second opinion of a colleague. These participants also reported the AI advice to be less useful. Surprisingly, requiring provisional decisions on cases in advance of the display of AI inferences did not lengthen the time participants spent on the task. The study provides generalizable and actionable insights for the deployment of clinical AI tools in human-in-the-loop systems and introduces a methodology for studying alternative designs for human-AI collaboration. We make our experimental platform available as open source to facilitate future research on the influence of alternate designs on human-AI workflows.
On multiple access channels with asymmetric feedback (2008)

In multiuser systems, the downlink capacity to different users is often different due to the near-far effect. We capture this asymmetry in the feedback link by introducing an asymmetric feedback model where different users get different amount of channel feedback from the base-station. Then, we derive the outage probability for the maximum-likelihood receiver, allowing us to study the impact of feedback asymmetry on multiuser performance. Interestingly, we discover that introducing systematic asymmetry in feedback can be beneficial in some cases, where only one user can adapt its power/rate to provide systemwide performance equivalent to that obtained by global feedback to all users.
Electrochemical Behavior of Some Sodium Nickel Oxides for a Sodium-Ion Battery (2015)

Sodium-ion batteries have been considered as a cheap alternative to lithium-ion batteries. Electrode materials for a sodium-ion battery and a lithium-ion battery have interesting similarities and differences in materials characteristics and electrochemical properties. Layered lithium nickel oxide, LiNiO 2 has been developed to achieve a high capacity battery, but it shows interslab cation mixing and poor thermal stability. Li 2 NiO 2 has also been studied mainly as a cathode additive to compensate the lithium loss at the anode side owing to the SEI formation. It can provide a large irreversible charging capacity at the first cycle, but it exhibits a significant oxygen evolution upon charging. In this study, we report electrochemical properties of their sodium analogues for a sodium-ion battery. The materials were prepared via solid state reactions and characterized with powder XRD and SEM. Electrochemical properties of them are examined with coin half- and full-cells, and further characterized with ex-situ electrode XRD analysis. The experimental data was correlated to DFT+U calculations. Details on the materials and electrochemical properties will be presented at the meeting.
A software radio implementation for spectrum hole sensing in cognitive mobile networks (2013)

This paper presents a software radio implementation for spectrum hole sensing in cognitive mobile networks. We propose a multi-channel spectrum sensing method for spectrum hole detection, exploiting Fast Fourier Transform (FFT) filter bank (FFTFB). Our method tests multiple frequency bands at the same time, detecting multiple spectrum holes at once. We modify a recently introduced two-dwell sensing method, implementing the second stage under a software radio approach (i.e. using a digital reprogrammable hardware). In particular, a filter bank implementation varying the length of the FFT is deeply investigated. FFTs with a small number of coefficients, that can be computed with fast and low complexity algorithms (multiplication free), are exploited and their performance discussed in terms of required complexity. The obtained results have evidenced the efficiency of such an approach for cognitive mobile networks.
Magnetic Equivalent Circuit Modeling of Induction Machines Design-Oriented Approach with Extension to 3-D (2007)

Advances in power electronics technology, materials, and changing application requirements are driving advances in electric machines. But induction machines are not often considered for new design possibilities. One reason is that computer-aided design tools for induction machines are not readily available. Analytical and finite element models have significant disadvantages that limit their effectiveness for induction machine design. This paper presents a magnetic equivalent circuit modeling approach that is geared towards design. Magnetic equivalent circuits are flexible in terms of size and accuracy, have moderate computational complexity, and are easily parameterized. They can be extended readily to three-dimensional analysis. Comparisons with results from finite element models and measurements indicate that magnetic equivalent circuits, corrected for local saturation, are a promising option for a design tool.
The State of the Uniform: Attacks on Encrypted Databases Beyond the Uniform Query Distribution (2020)

Recent foundational work on leakage-abuse attacks on encrypted databases has broadened our understanding of what an adversary can accomplish with a standard leakage profile. Nevertheless, all known value reconstruction attacks succeed under strong assumptions that may not hold in the real world. The most prevalent assumption is that queries are issued uniformly at random by the client. We present the first value reconstruction attacks that succeed without any knowledge about the query or data distribution. Our approach uses the search-pattern leakage, which exists in all known structured encryption schemes but has not been fully exploited so far. At the core of our method lies a support size estimator, a technique that utilizes the repetition of search tokens with the same response to estimate distances between encrypted values without any assumptions about the underlying distribution. We develop distribution-agnostic reconstruction attacks for both range queries and k-nearest-neighbor (k-NN) queries based on information extracted from the search-pattern leakage. Our new range attack follows a different algorithmic approach than state-of-the-art attacks, which are fine-tuned to succeed under the uniformly distributed queries. Instead, we reconstruct plaintext values under a variety of skewed query distributions and even outperform the accuracy of previous approaches under the uniform query distribution. Our new k-NN attack succeeds with far fewer samples than previous attacks and scales to much larger values of k. We demonstrate the effectiveness of our attacks by experimentally testing them on a wide range of query distributions and database densities, both unknown to the adversary.
Sensitivity of Human Renal Cell Carcinoma Lines to TNF, Adriamycin, and Combination: Role of TNF mRNA Induction in Overcoming Resistance (1993)

We have examined 6 human renal cell carcinoma (RCC) cell lines for their sensitivity and resistance to the cytolytic effect of tumor necrosis factor (TNF) and adriamycin (ADR), alone or in combination. The results of cytotoxicity mediated by TNF and ADR showed no direct correlation as TNF resistant lines were sensitive to ADR while the TNF sensitive lines were resistant. The combination of TNF and ADR resulted in enhanced cytotoxicity against the tumor lines. Induction of TNF mRNA and protein has been suggested as a mechanism of resistance to TNF in certain tumors. Resistant and sensitive lines were capable of upregulating TNF mRNA after treatment with TNF or PMA+ionophore for periods as short as 1 hour, but only the resistant lines were able to secrete detectable levels of TNF protein. Therefore, a positive correlation existed between resistance to TNF and production and secretion of TNF by the cell lines. In the presence of the protein synthesis inhibitor cycloheximide (CHX), the TNF mRNA level in the TNF resistant lines was increased while the sensitive lines required an additional signal, such as exogenous TNF, to upregulate the mRNA. Due to the enhanced cytotoxicity seen with the combination of TNF and ADR, we determined the effect of this combination on the levels of TNF mRNA. As examined in a constitutively TNF expressing line, ADR alone reduced the constitutive mRNA level and, in combination with TNF, reduced the level of induction produced by TNF. This downregulation of TNF mRNA by ADR may play a role in the enhanced cytotoxicity seen with combined TNF and ADR treatment. The present study demonstrates that RCC cell lines differ in their sensitivity and/or resistance to TNF. Further, ADR and/or TNF resistant RCC lines can be rendered sensitive by combining TNF and ADR. The constitutive and/or inductive secretion of TNF by certain lines and its relationship to tumor pathogenesis as well as overcoming resistance are discussed.
ChemInform Abstract: A General Method for the Synthesis of Polymeric Binary Fluorides Exemplified by AgF3, NiF4, RuF4, and OsF4. (1989)

Abstract Treatment of the pentafluoroxenonmetal fluorides (I), (V), and (VII) with the fluoride ion acceptor AsF 5 at low temperatures yields the fluorides (II), (VI), and (VIII).
Toward Plasma Proteome Profiling with Ion Mobility-Mass Spectrometry (2006)

Differential, functional, and mapping proteomic analyses of complex biological mixtures suffer from a lack of component resolution. Here we describe the application of ion mobility-mass spectrometry (IMS-MS) to this problem. With this approach, components that are separated by liquid chromatography are dispersed based on differences in their mobilities through a buffer gas prior to being analyzed by MS. The inclusion of the gas-phase dispersion provides more than an order of magnitude enhancement in component resolution at no cost to data acquisition time. Additionally, the mobility separation often removes high-abundance species from spectral regions containing low-abundance species, effectively increasing measurement sensitivity and dynamic range. Finally, collision-induced dissociation of all ions can be recorded in a single experimental sequence while conventional MS methods sequentially select precursors. The approach is demonstrated in a single, rapid (3.3 h) analysis of a plasma digest sample where abundant proteins have not been removed. Protein database searches have yielded 731 high confidence peptide assignments corresponding to 438 unique proteins. Results have been compiled into an initial analytical map to be used -after further augmentation and refinement- for comparative plasma profiling studies.
Crystal structure of dimethyl 4,4'-(cyclopenta-3,5-diene-1,3-diyl)- bis(2,3,5,6-tetrafluorobenzoate), C21H10F8O4 (2009)

Article Crystal structure of dimethyl 4,4'-(cyclopenta-3,5-diene-1,3-diyl)- bis(2,3,5,6-tetrafluorobenzoate), C21H10F8O4 was published on December 1, 2009 in the journal Zeitschrift für Kristallographie - New Crystal Structures (volume 224, issue 4).
Development of low-temperature transistor modules to improve the MSFC mid-infrared array (1986)

This report describes the low-temperature transistor modules designed for use with the MSFC mid-infrared array. The modules were developed in the Space Science Laboratory at Marshall Space Flight Center with Center Director's Discretionary Funds. The transistors (JFETs), which operate at a temperature of 77 K, are epoxied to a copper surface attached to a Teflon substrate. The module substrate insulates the JFETs from the 1.5K detector work surfaces and provides a convenient mounting structure for additional components such as solder pins. These modules have maintained their structural integrity during repeated temperature cycling, and they have to be convenient during maintenance and servicing of the infrared array.
Resting-state connectivity stratifies premanifest Huntington’s disease by longitudinal cognitive decline rate (2020)

Patient stratification is critical for the sensitivity of clinical trials at early stages of neurodegenerative disorders. In Huntington's disease (HD), genetic tests make cognitive, motor and brain imaging measurements possible before symptom manifestation (pre-HD). We evaluated pre-HD stratification models based on single visit resting-state functional MRI (rs-fMRI) data that assess observed longitudinal motor and cognitive change rates from the multisite Track-On HD cohort (74 pre-HD, 79 control participants). We computed longitudinal performance change on 10 tasks (including visits from the preceding TRACK-HD study when available), as well as functional connectivity density (FCD) maps in single rs-fMRI visits, which showed high test-retest reliability. We assigned pre-HD subjects to subgroups of fast, intermediate, and slow change along single tasks or combinations of them, correcting for expectations based on aging; and trained FCD-based classifiers to distinguish fast- from slow-progressing individuals. For robustness, models were validated across imaging sites. Stratification models distinguished fast- from slow-changing participants and provided continuous assessments of decline applicable to the whole pre-HD population, relying on previously-neglected white matter functional signals. These results suggest novel correlates of early deterioration and a robust stratification strategy where a single MRI measurement provides an estimate of multiple ongoing longitudinal changes.
Spinal 5‐HT2 receptor‐mediated facilitation of pudendal nerve reflexes in the anaesthetized cat (1996)

1. 5-Hydroxytryptamine (5-HT) is intimately associated with central sympathetic and somatic control of the lower urinary tract. The sympathetic and somatic innervation of the lower urinary tract is conveyed through efferent axons of the hypogastric and pudendal nerves, respectively. 2. The present study examined the effects of 2,5-dimethoxy-4-iodophenylisopropylamine (DOI), a 5-HT2 receptor subtype-selective agonist, on evoked potentials recorded from the central ends of the hypogastric and pudendal nerves in response to electrical stimulation of afferent fibres in the pelvic and pudendal nerves, respectively. Various spinalization paradigms were employed to localize the site of action. All cats were pretreated with xylamidine (1 mg kg-1), a peripherally-restricted 5-HT2 receptor antagonist. 3. In acute spinal cats, DOI (0.01-3 mg kg-1, i.v.) reliably produced dose-dependent increases in the pudendal nerve reflex (to 228 +/- 31% of control). These increases were reversed by the 5-HT2 receptor-selective antagonist, LY53857 (0.3-3 mg kg-1, i.v.). On the other hand, in spinally-intact cats, DOI produced no significant changes in the pudendal reflex. However, within minutes of spinalization of DOI-pretreated cats, a marked increase (to 221 +/- 16% of control) in the pudendal reflex was observed which could be reversed by LY53857. No significant effects were observed on hypogastric reflexes in either acute spinal or spinally-intact cats following DOI administration. No effects were seen in either spinally-intact or acute spinal animals when LY53857 was administered as the initial drug. 4. These results indicate that activation of spinal 5-HT2 receptors facilitates pudendal reflexes. In spinally-intact cats, it is hypothesized that DOI activates supraspinal pathways that mediate inhibition of the pudendal reflexes and counteracts the facilitatory effects of spinal 5-HT2 receptor activation.
QWIP research and development of 320 x 256 QWIP arrays in ElOp (1997)

As second generation FLIR systems become a reality the need for a reliable, high performance, moderately priced matrix arrays in the 8 - 12 micron atmospheric window becomes a real demand. At the same time, the remarkable advancement of QWIP technology over the past few years makes it one of the best candidates for such applications that suffice in the resolution provided by 320 by 256 pixel arrays. According to its fast advancement it could be expected that in the near future also the requirements of high-end applications will be met by QWIP technology. In light of this potential, the QWIP program in EL-OP was recently started in order to develop in- house QWIP technology and demonstrate 320 by 256 pixel image. Additionally we take part in scientific activities in a joint project with leading Israeli university groups. Preliminary results are presented, including the fabrication of QWIP arrays and measurement of single detectors. Measurement results show D* greater than 5 X 10<SUP>10</SUP> Jones and responsivity approximately equals 0.5 A/W. Additionally, an optimization method for quasi-random scattering arrays is briefly presented.