gebhart/patrepeval huggingface dataset:
Real-Time Noncoherent UWB Positioning Radar With Millimeter Range Accuracy: Theory and Experiment (2009)

In this paper, we propose a novel architecture for ultra-wideband (UWB) positioning systems, which combines the architectures of carrier-based UWB systems and traditional energy detection-based UWB systems. By implementing the novel architecture, we have successfully developed a standalone noncoherent system for positioning both static and dynamic targets in an indoor environment with approximately 2 and 5 mm of 3-D accuracy, respectively. The results are considered a great milestone in developing such technology. 1-D and 3-D experiments have been carried out and validated using an optical reference system, which provides better than 0.3-mm 3-D accuracy. This type of indoor high-accuracy wireless localization system has many unique applications including robot control, surgical navigation, sensitive material monitoring, and asset tracking.
Effect of Fuel Parameters on Speciated Hydrocarbon Emissions from a Direct Injection Spark Ignition Engine (2000)

&lt;div class="htmlview paragraph"&gt;A 1998 Toyota Corona passenger car with a direct injection spark ignition (DISI) engine was tested over the Federal Test Procedure (FTP) driving cycle. Speciated engine-out hydrocarbon emissions were measured. Seven fuels were used for these tests: five blended fuels and two pure hydrocarbon fuels. One of the blended fuels was CARB Phase 2 reformulated gasoline which was used as the reference fuel. The remaining four blended fuels were made from refinery components to meet specified distillation profiles. The pure hydrocarbon fuels were iso-octane and toluene - an alkane and an aromatic with essentially identical boiling points. The five blended fuels can be grouped to examine the effects of fuel volatility and MTBE. Additionally, correlations were sought between the fuel properties and the Specific Reactivity, the exhaust “toxics”, and the pass-through of unburned fuel species.&lt;/div&gt;
Sub-micron lines patterning into silica using water developable chitosan bioresist films for eco-friendly positive tone e-beam and UV lithography (2018)

International audience
Wilson disease of the brain: MR imaging. (1985)

Twenty-three patients with biochemically proved Wilson disease underwent magnetic resonance (MR) imaging of the brain. Positive findings, believed secondary to this condition, were found in 15 subjects. Findings varied among patients, but there were striking similarities between certain groups of patients. Areas of abnormal signal were seen in the lenticular, thalamic, caudate, and dentate nuclei, as well as in the brain stem; in these areas, the abnormalities were bilaterally symmetric. A smaller number of patients had asymmetric focal white-matter lesions. Correlation of the MR findings with clinical symptoms was generally good. Repeat imaging was performed on five patients at intervals ranging from 4 to 8 months; none showed significant interval change.
Atom mirror etched from a hard drive (2003)

We describe the fabrication of an atom mirror by etching of a common hard drive, and we report the observation of specular retroreflection of 11 μK cesium atoms using this mirror. The atoms were trapped and cooled above the hard drive using the mirror magneto-optical trap technique, and upon release, two full bounces were detected. The hard drive atom mirror will be a useful tool for both atom optics and quantum computation.
Chemical Synthesis of Homogeneous Glycoproteins for the Study of Glycoprotein Quality Control System (2015)

Abstract The glycoprotein quality control system exists in the endoplasmic reticulum to maintain protein homeostasis and prevent accumulation of aberrant glycoproteins. Folding sensor enzyme uridine diphosphate (UDP)glucose : glycoprotein glucosyltransferase (UGGT) plays an important role in this system through its ability to discriminate immature or misfolded glycoproteins from native ones. UGGT transfers a glucose residue to a glycoprotein containing Man 9 GlcNAc 2 (M9; Man=mannose, GlcNAc= N ‐acetyl‐ D ‐glucosamine) N ‐glycan only when the glycoprotein has not attained a native form. We chemically prepared homogeneous glycoproteins containing M9 N ‐glycan in the native form as well as in misfolded forms and examined them as substrates of UGGT. Glucose transfer to misfolded glycoproteins was clearly observed by LC‐MS, but glycoproteins in the native form were barely glucosylated. Furthermore, we constructed an in vitro glycoprotein folding system in the presence of UGGT and found out that all folding intermediates which appeared during folding were also glucosylated. Through these experiments, we demonstrated the usefulness of chemically synthesized homogeneous glycoproteins as probes to gain insights into the molecular basis of the glycoprotein quality control system.
Different Costimulatory and Growth Factor Requirements for CD4+ and CD8+ T Cell-Mediated Rejection (2004)

Costimulatory signals and growth factor signals play a key role in commanding T cell activation and T cell effector function. However, how costimulatory signals and growth factor signals interact and integrate into the activation program of CD4(+) and CD8(+) T cells during the allograft response remains poorly defined. In the present study we found that either CD4- or CD8-deficient mice can vigorously reject the skin allografts. Blocking rapamycin-sensitive growth factor signals produced long term skin allograft survival in CD4-deficient mice (mean survival time, >120 days), but not in CD8-deficient mice (mean survival time, 20 days). Analysis of CFSE-labeled cells proliferating in the allogeneic hosts revealed that clonal expansion of CD4(+) T cells in vivo was more resistant to growth factor blockade than that of CD8(+) T cells. However, blockade or genetic absence of CD28/CD154 costimulatory molecules rendered CD4(+) T cell-mediated rejection sensitive to rapamycin, and long term skin allograft survival can be readily induced by rapamycin in the absence of CD28/CD154 signals (>100 days). Furthermore, blocking OX40 costimulation induced long term skin allograft survival in CD4-deficient mice and CD8-deficient mice when both CD28 and CD154 were transiently blocked. We conclude that CD4(+) and CD8(+) T cells exhibit distinct sensitivity to growth factor blockade in transplant rejection, and CD28/CD154-independent rejection is sensitive to rapamycin and appears to be supported by OX40 costimulation.
Evaluierung der Morbiditäten und Co-Morbiditäten von Patienten mit Diabetes, die in diabetologischen Schwerpunkt-Praxen behandelt werden (2011)

Fragestellung: Ziel dieser Evaluierung war die Charakterisierung der Morbiditäten und Co-Morbiditäten von Patienten mit Diabetes.
Patient-derived tumor xenografts in humanized NSG-SGM3 mice: A new immuno-oncology platform. (2016)

3074 Background: Humanized mice engrafted with tumors enable in vivo investigation of the interactions between the human immune system and human cancer. We have recently found that humanized NOD-scid IL2Rγnull(NSG) mice bearing patient-derived xenografts (PDX) allow efficacy studies of check-point inhibitors. Next generation NSG strains include triple transgenic NSG mice expressing human cytokines KITLG, CSF2, and IL-3 (NSG-SGM3). Methods: We provide a direct comparison of check-point inhibitors evaluation in NSG and NSG-SGM3 mice engrafted with CD34+ human hematopoietic progenitor cells (HPCs) from the same donor and implanted with PDX tumors. PDX tumors were engrafted into partially HLA-matched hu-NSG-SGM3 mice at 9 weeks post engraftment. Tumor-infiltrating myeloid cells were examined. Two PDX models and one cancer cell line with high PDL1 levels were used to test respond to anti-PD1 therapy in hu-NSG-SGM3 mice. Results: Reconstitution of human immune system in the blood was faster and more robust in NSG-SGM3 compared to NSG recipients throughout the course of the study (18 weeks). Human CD45+ cells reached 25% of total blood cells at week 4 in hu-NSG-SGM3 mice and at week 9 in hu-NSG mice. A majority of blood hCD45+ cells (55%) in hu-NSG-SGM3 at week 4 were CD33+ myeloid cells. By comparison, efficiency of human CD33+ cells (15%) in the circulation was poor in hu-NSG mice. Moreover, circulating hCD3+ T cells reached 10% at week 9 and included regulatory T cells (Tregs). Hu-NSG mice displayed comparable hCD3+ T cells in the blood only at 12-15 weeks and did not contain Tregs. Tumor-infiltrating myeloid cells will be discussed. High PD-1 expression by CD8+T cells and Tregs were present within the breast cancer microenvironment suggesting anergy and immunosuppression in hu-NSG-SGM3 mice. Treatment with the anti-PD-1 receptor antibody pembrolizumab significantly reduced tumor growth and the PD-1 expression level on lymphocytes. Conclusions: PDX-bearing hu-NSG-SGM3 mice might serve as a new and improved platform for preclinical immuno-oncology efficacy studies.
Dual Six-Port Reflectometer Systems Using Waveguide in the Frequency Range 18-50 GHz (1989)

The development and evaluation of three dual six-port reflectometer systems, that use WR-42, WR-28 and WR-22 waveguide, is discussed; these cover the frequency range 18-50 GHz. The systems are capable of automated or semi-automated operation and will provide complex scattering parameter data for customer waveguide components, as well as effective efficiency data for power sensors. Some representative measurement data are presented that demonstrate that these systems yield results that do not differ significantly from those obtained using older measurement systems. Some discussion of measurement uncertainties is also included.
Generating synthetic Internet- and IP-topologies using the Stochastic-Block-Model (2017)

Developing models to generate realistic graphs of communication networks often requires a deep understanding and extensive analysis of the underlying network structure. Since deployed communication networks are dynamic, the findings a generator is based on might lose validity. We alleviate the need for extensive analysis of graphs by estimating parameters of a probabilistic model. The model parameters encode the structure of the graph, which is thus learned in an unsupervised fashion. Synthetic graphs can be generated from the model and will have the structure previously inferred. For this, we use the Stochastic-Block-Model (SBM) and the Degree-Corrected-Block-Model (DCBM), a variant allowing for heavy tailed degree distributions. The models originate in the social sciences and separate a graph into groups of nodes. To show the applicability of the models to the task of synthetic graph generation in the domain of communication networks, we use one router level and one IP-to-IP communication graph. We assert the quality of the generated models by evaluating a number of graph features and comparing our results to those obtained with the network generator Orbis. We find our approach to be on par with, or even outperforming Orbis. Furthermore, the models are able to capture large-scale structure in communication networks.
Total Synthesis of Mucocin (1998)

The synthesis of the potent antitumor agent, mucocin, 1, was efficiently achieved in 20 steps from cyclododecatriene, thus confirming the proposed structure of this unusual member of the Annonaceous acetogenins. Demonstrating the power of the “naked” carbon skeleton strategy, all seven asymmetric centers in the key fragment of the molecule were introduced by double AE reaction followed by double AD reaction. Simultaneous two ring closure reactions provided both the THP and THF rings in a single step.
Nowa architektura zabezpieczenia odległościowego w świetle obecnych wymagań systemu energetycznego (2015)

Wydawnictwo SIGMA-NOT wydaje czasopisma fachowe informujące swoich czytelników o najnowszych osiągnięciach naukowych i nowoczesnych rozwiązaniach technicznych w Polsce i na świecie, popularyzuje problemy techniczne oraz poszerza wiedzę i kulturę techniczną.
LMM: an OWL-DL MetaModel to Represent Heterogeneous Lexical Knowledge. (2008)

In this paper we present a Linguistic Meta-Model (LMM) allowing a semiotic-cognitive representation of knowledge. LMM is freely available and integrates the schemata of linguistic knowledge resources, such as WordNet and FrameNet, as well as foundational ontolo-gies, such as DOLCE and its extensions. In addition, LMM is able to deal with multilinguality and to represent individuals and facts in an open domain perspective. 1.
Avian Influenza A(H5N1) and A(H9N2) Seroprevalence and Risk Factors for Infection Among Egyptians: A Prospective, Controlled Seroepidemiological Study (2014)

Results of this study indicate that the number of humans infected with avian influenza viruses is much larger than the number of reported confirmed cases. In an area where these viruses are enzootic in the poultry, human exposure to and infection with avian influenza becomes more common.
Supplemental Tables from CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1–Dependent IGF-1 Signaling (2023)

&lt;p&gt;Table S1. qRT-PCR primers. Table S2. CRM1 expression among different cancer types patient sample tissues. Table S3. CRM1 Expression among different cancer types ( cancer cell lines from CCLE database). Table S4. patients clinical infomation and h score sorting. Table S5. Overlaps of lists of genes in EW8 and SKES1 under treatment with KPT-330. Table S6. Overlaps of lists of genes by KPT-330 and EWS-FLI1 regulation.&lt;/p&gt;
Proceedings of the third ACM SIGPLAN X10 Workshop (2013)

We are delighted to welcome you to the 2013 ACM SIGPLAN X10 Workshop | X10'13. This third edition of the workshop will provide a forum for X10 developers, researchers, and educators to interact with the larger X10 community by sharing their insights, experiences, and plans.
Fine Mapping of Leaf Trichome Density Revealed a 747-kb Region on Chromosome 1 in Cold-Hardy Hybrid Wine Grape Populations (2021)

Segregation for leaf trichome density was observed in a cold-hardy hybrid grape population GE1025 (<i>N</i> = ∼125, MN1264 × MN1246) that was previously used to detect a quantitative trait locus (QTL) underlying foliar phylloxera resistance on chromosome 14. Our hypothesis was that high trichome density was associated with resistance to phylloxera. Existing literature found trichome density QTL on chromosomes 1 and 15 using a hybrid grape population of "Horizon" × Illinois 547-1 and suggested a few candidate genes. To validate the reported QTL and our hypothesis, interval mapping was conducted in GE1025 with previous genotyping-by-sequencing (GBS) single nucleotide polymorphism (SNP) genotype data and phenotypic scores collected using a 0-6 trichome density scale at several leaf positions. Evaluations were done on replicated forced dormant cuttings in 2 years and on field-grown leaves in 1 year. There was no strong relationship between trichome density and phylloxera resistance except for a Pearson's correlation (r) of about -0.2 between a few trichome density traits and phylloxera severity traits at 2 and 3 weeks after infestation. Two genetic regions were repeatedly detected for multiple trichome density traits: from 10 to 20.7 Mbp (∼10 Mbp) on chromosome 1 for ribbon and simple density traits and from 2.4 to 8.9 Mbp on chromosome 10 for ribbon density traits, explaining 12.1-48.2 and 12.6-27.5% of phenotypic variation, respectively. To fine map, we genotyped a larger population, GE1783 (<i>N</i> = ∼1,023, MN1264 × MN1246), with conserved rhAmpSeq haplotype markers across multiple <i>Vitis</i> species and phenotyped 233 selected potential recombinants. Evaluations were conducted on field-grown leaves in a single year. The QTL for ribbon trichome density on adaxial vein and adaxial leaf and simple density on abaxial vein was fine mapped to 12.63-13.38 Mbp (747 kb) on chromosome 1. We found variations of MN1264 and MN1246 at candidate genes NAC transcription factor 29, EF-hand protein, and MYB140 in this region and three other surrounding candidate genes proposed previously. Even though no strong relationship between foliar phylloxera resistance and trichome density was found, this study validated and fine mapped a major QTL for trichome density using a cold-hardy hybrid grape population and shed light on a few candidate genes that have implications for different breeding programs.
Laser-assisted chemistry in the reaction of Mg(1S) with CO2 to yield MgO(B 1Σ+) (1988)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Joseph J. BelBruno, George A. Raiche; Laser‐assisted chemistry in the reaction of Mg(1S) with CO2 to yield MgO(B 1Σ+). AIP Conf. Proc. 1 October 1988; 172 (1): 577–579. https://doi.org/10.1063/1.37419 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Differential Quantitative Determination of Site-Specific Intact N-Glycopeptides in Serum Haptoglobin between Hepatocellular Carcinoma and Cirrhosis Using LC-EThcD-MS/MS (2018)

Intact N-glycopeptide analysis remains challenging due to the complexity of glycopeptide structures, low abundance of glycopeptides in protein digests, and difficulties in data interpretation/quantitation. Herein, we developed a workflow that involved advanced methodologies, the EThcD-MS/MS fragmentation method and data interpretation software, for differential analysis of the microheterogeneity of site-specific intact N-glycopeptides of serum haptoglobin between early hepatocellular carcinoma (HCC) and liver cirrhosis. Haptoglobin was immunopurified from 20 μL of serum in patients with early HCC, liver cirrhosis, and healthy controls, respectively, followed by trypsin/GluC digestion, glycopeptide enrichment, and LC-EThcD-MS/MS analysis. Identification and differential quantitation of site-specific N-glycopeptides were performed using a combination of Byonic and Byologic software. In total, 93, 87, and 68 site-specific N-glycopeptides were identified in early HCC, liver cirrhosis, and healthy controls, respectively, with high confidence. The increased variety of N-glycopeptides in liver diseases compared to healthy controls was due to increased branching with hyper-fucosylation and sialylation. Differential quantitation analysis showed that 5 site-specific N-glycopeptides on sites N184 and N241 were significantly elevated in early HCC compared to cirrhosis ( p < 0.05) and normal controls ( p ≤ 0.001). The result demonstrates that the workflow provides a strategy for detailed profiles of N-glycopeptides of patient samples as well as for relative quantitation to determine the level changes in site-specific N-glycopeptides between disease states.
Practical Syntheses of a CXCR3 Antagonist (2011)

Two new, reliable syntheses of a pyrido[2,3-d]-pyrimidine inhibitor of the CXCR3 receptor are described. A nine-step synthesis of the CXCR3 inhibitor (1) from 2-aminonicotinic acid was demonstrated on a multikilogram scale and incorporates a classic resolution to deliver the enantioenriched active pharmaceutical ingredient (API). A second synthesis of the CXCR3 inhibitor starts from (+)-(D)-Boc alanine and 2-chloronicotinic acid and utilizes a Goldberg coupling. This second synthesis, performed on a gram scale, intersects the former route at a common intermediate thereby completing a formal synthesis of the enantioenriched API in higher overall yield without the need for a resolution.
Interaction-Aware Behavior Planning for Autonomous Vehicles Validated With Real Traffic Data (2020)

Abstract Autonomous vehicles (AVs) need to interact with other traffic participants who can be either cooperative or aggressive, attentive or inattentive. Such different characteristics can lead to quite different interactive behaviors. Hence, to achieve safe and efficient autonomous driving, AVs need to be aware of such uncertainties when they plan their own behaviors. In this paper, we formulate such a behavior planning problem as a partially observable Markov Decision Process (POMDP) where the cooperativeness of other traffic participants is treated as an unobservable state. Under different cooperativeness levels, we learn the human behavior models from real traffic data via the principle of maximum likelihood. Based on that, the POMDP problem is solved by Monte-Carlo Tree Search. We verify the proposed algorithm in both simulations and real traffic data on a lane change scenario, and the results show that the proposed algorithm can successfully finish the lane changes without collisions.
Advances in porous and nanoscale catalysts for viable biomass conversion (2019)

Heterogeneous catalysis is a promising technology for the valorization of renewable biomass to sustainable advanced fuels and fine chemicals. Porosity and nanostructure are the most versatile features of heterogeneous solid catalysts, which can greatly determine the accessibility of specific active sites, reaction mechanisms, and the selectivity of desirable products. Hence, the precise tuning of porosity and nanostructure has been a potential strategy towards developing novel solid catalysts with indispensable characteristics for efficient biomass valorization. Herein, we present a timely and comprehensive review of the recent advances in catalytic biomass conversions over microporous zeolites, mesoporous silicas, and nanostructured metals/metal oxides. This review covers the catalytic processing of both edible (lipids and starch) and non-edible (lignocellulose) biomass as well as their derived compounds, along with a systematic evaluation of catalyst reusability/kinetic/mechanistic aspects in the relevant processes. The key parameters essential for tailoring particle size, morphology, porosity, acid-base, and redox properties of solid catalysts are emphasized, while discussing the ensuing catalytic effects towards the selective conversion of biomass into desirable chemicals. Special attention has been drawn to understand the role of water in liquid phase biomass conversions as well as the hydrothermal stability and the deactivation of nanoporous catalysts. We believe this comprehensive review will provide new insights towards developing state-of-the-art solid catalysts with well-defined porosity and nanoscale properties for viable biomass conversion.
Transcriptional role of p53 in interferon-mediated antiviral immunity (2008)

Tumor suppressor p53 is activated by several stimuli, including DNA damage and oncogenic stress. Previous studies (Takaoka, A., S. Hayakawa, H. Yanai, D. Stoiber, H. Negishi, H. Kikuchi, S. Sasaki, K. Imai, T. Shibue, K. Honda, and T. Taniguchi. 2003. Nature. 424:516-523) have shown that p53 is also induced in response to viral infections as a downstream transcriptional target of type I interferon (IFN) signaling. Moreover, many viruses, including SV40, human papillomavirus, Kaposi's sarcoma herpesvirus, adenoviruses, and even RNA viruses such as polioviruses, have evolved mechanisms designated to abrogate p53 responses. We describe a novel p53 function in the activation of the IFN pathway. We observed that infected mouse and human cells with functional p53 exhibited markedly decreased viral replication early after infection. This early inhibition of viral replication was mediated both in vitro and in vivo by a p53-dependent enhancement of IFN signaling, specifically the induction of genes containing IFN-stimulated response elements. Of note, p53 also contributed to an increase in IFN release from infected cells. We established that this p53-dependent enhancement of IFN signaling is dependent to a great extent on the ability of p53 to activate the transcription of IFN regulatory factor 9, a central component of the IFN-stimulated gene factor 3 complex. Our results demonstrate that p53 contributes to innate immunity by enhancing IFN-dependent antiviral activity independent of its functions as a proapoptotic and tumor suppressor gene.