gebhart/patrepeval huggingface dataset:
Full-Duplex Communication for ISAC: Joint Beamforming and Power Optimization (2023)

Beamforming design has been widely investigated for integrated sensing and communication (ISAC) systems with full-duplex (FD) sensing and half-duplex (HD) communication, where the base station (BS) transmits and receives radar sensing signals simultaneously while the integrated communication operates in either downlink or uplink. To achieve higher spectral efficiency, in this paper, we extend existing ISAC beamforming design to a general case by considering the FD capability for both radar and communication. Specifically, we consider an FD ISAC system, where the BS performs target detection and communicates with multiple downlink users and uplink users reusing the same time and frequency resources. We jointly optimize the downlink dual-functional transmit signal and the uplink receive beamformers at the BS and the transmit power at the uplink users. The problems are formulated under two criteria: power consumption minimization and sum rate maximization. The downlink and uplink transmissions are tightly coupled due to both the desired target echo and the undesired interference received at the BS, making the problems challenging. To handle these issues in both cases, we first determine the optimal receive beamformers in closed forms with respect to the BS transmit beamforming and the user transmit power. Subsequently, we invoke these results to obtain equivalent optimization problems and propose iterative algorithms to solve them. In addition, we consider a special case under the power minimization criterion and propose an alternative low complexity design. Numerical results demonstrate that the optimized FD communication-based ISAC brings tremendous improvements in terms of both power efficiency and spectral efficiency compared to the conventional ISAC with HD communication.
TOTAL HIP ARTHROPLASTY FOR PERIACETABULAR TUMOURS UTILIZING POROUS TANTALUM ACETABULAR COMPONENTS (2009)

We report a series of sixteen total hip arthroplasties utilizing a porous tantalum trabecular metal acetabular component in patients with tumors of the hip. The study included eight men and eight women with an average age of 59.3 (range 22–80 years). Two patients had benign but locally recurrent disease destructive of bone (Langerhan’s Cell Histiocytosis and Rosi Dorfman Disease), while fourteen had malignant lesions. The latter included six myeloma, two lymphoma, and six metastatic carcinoma (three breast, one prostate, one lung, and one unknown site). Fifteen patients had prior radiation therapy. The technique used was determined by the extent of the lesion and the quality of remaining host bone. In eight patients major deficiencies necessitated augmentation of the porous tantalum cup with an anti-protrusio device “over -the top” a cup-cage construct. Porous tantalum augments were utilised with the cup to fill defects in the acetabulum in seven patients. Postoperative complications were seen in four cases (DVT, DIC, pneumonia, and one death from c. difficile colitis). Postoperatively, the majority of the patients had excellent pain relief and improved ambulatory status. No clinical failures have been observed at follow-up (mean 12.5 months, range twenty days-twenty-eight months). There have been no re-operations. Radiographically, no migration or evidence of implant loosening has been observed.
Fluorine‐Doped Antiperovskite Electrolyte for All‐Solid‐State Lithium‐Ion Batteries (2016)

A fluorine-doped antiperovskite Li-ion conductor Li2 (OH)X (X=Cl, Br) is shown to be a promising candidate for a solid electrolyte in an all-solid-state Li-ion rechargeable battery. Substitution of F(-) for OH(-) transforms orthorhombic Li2 OHCl to a room-temperature cubic phase, which shows electrochemical stability to 9 V versus Li(+) /Li and two orders of magnitude higher Li-ion conductivity than that of orthorhombic Li2 OHCl. An all-solid-state Li/LiFePO4 with F-doped Li2 OHCl as the solid electrolyte showed good cyclability and a high coulombic efficiency over 40 charge/discharge cycles.
Chemoenzymatic Synthesis of Both Enantiomers of Fluoxetine, Tomoxetine and Nisoxetine: Lipase‐Catalyzed Resolution of 3‐Aryl‐3‐hydroxypropanenitriles. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Relationship of Gene Expression and Chromosomal Abnormalities in Colorectal Cancer (2006)

Several studies have verified the existence of multiple chromosomal abnormalities in colon cancer. However, the relationships between DNA copy number and gene expression have not been adequately explored nor globally monitored during the progression of the disease. In this work, three types of array-generated data (expression, single nucleotide polymorphism, and comparative genomic hybridization) were collected from a large set of colon cancer patients at various stages of the disease. Probes were annotated to specific chromosomal locations and coordinated alterations in DNA copy number and transcription levels were revealed at specific positions. We show that across many large regions of the genome, changes in expression level are correlated with alterations in DNA content. Often, large chromosomal segments, containing multiple genes, are transcriptionally affected in a coordinated way, and we show that the underlying mechanism is a corresponding change in DNA content. This implies that whereas specific chromosomal abnormalities may arise stochastically, the associated changes in expression of some or all of the affected genes are responsible for selecting cells bearing these abnormalities for clonal expansion. Indeed, particular chromosomal regions are frequently gained and overexpressed (e.g., 7p, 8q, 13q, and 20q) or lost and underexpressed (e.g., 1p, 4, 5q, 8p, 14q, 15q, and 18) in primary colon tumors, making it likely that these changes favor tumorigenicity. Furthermore, we show that these aberrations are absent in normal colon mucosa, appear in benign adenomas (albeit only in a small fraction of the samples), become more frequent as disease advances, and are found in the majority of metastatic samples.
Use of a Resorbable Sheet in Iliac Crest Reconstruction in a Sheep Model (2002)

Iliac crest bone graft harvesting can result in major complications that occur at rates of approximately 6%-8%. The objective of this study was to evaluate the postoperative regeneration of iliac crest donor defects in an animal model after harvesting a full-thickness tricortical graft. In skeletally mature sheep, a tricortical iliac crest graft was harvested. The graft sites were allowed to heal nonprotected or protected with the resorbable polylactic acid sheet material, MacroPore OS Protective Sheeting, (MacroPore Biosurgery, San Diego, Calif). After 6 months of healing, the sites were assessed by examination of undecalcified histologic sections. Histomorphometric measurements of the original defect area, the area of new bone within the defect site, and the percentage of defect filled with new bone were quantified for both control and protected groups. In all histologic sections, new bone growth within the defect sites appeared normal, with no excessive inflammatory cells observed. The developing bone tissue appeared to be remodeling normally. For the nonprotected sites, the area of new bone averaged 16.3 mm2 (+/-7.2 mm2), and the percentage of the defect area filled with bone averaged 10.7% (+/-6.5%). In the protected sites, the area of new bone averaged 64.8 mm2 (+/-11.6 mm2) and the percentage of the defect area filled with bone averaged 25.9% (+/-1.6%). Both differences in area of new bone growth and percentage of defect area filled were statistically significant. Literature review has indicated that regeneration of donor site defects is desirable. Based upon the results of the present study, MacroPore resorbable protective sheeting can improve bone regeneration significantly within the donor site following tricortical iliac crest graft harvesting.
Materials Engineering for Future Interconnects: “Catalyst-Free” Electroless Cu Deposition on Self-Assembled Monolayer Alternative Barriers (2009)

An alternative bottom-up Cu electroless deposition (ELD) method without other catalyst material activation is the focus of this paper. The process consists of reducing the Cu ions in a solution via standard reducing agents such as dimethylamine borane. The reaction pH and ionic strength values can be modulated to impart to the metallic Cu particle surface an opposite charge with respect to the deposition substrate functionalized by the 3-aminopropyltrimethoxysilane (APTS) self-assembled monolayer used as a diffusion barrier. At neutral pH, the negatively charged Cu particles are electrostatically attracted by the positively charged groups, and they can form strong interfacial complexes if the required activation energy budget is supplied. A design of the experiment is carried out to optimize the critical deposition parameters such as temperature, time, Cu ion concentration, and pH. The formed ELD Cu nuclei positioned preferentially on the APTS layer, showing a wetting behavior that is accentuated upon anneal, leading to a decrease in surface roughness that corresponds to an increase in film closure. The observed debonding energy of the ELD Cu/APTS surface is ca. before anneal, while it reaches ca. 4.5 and after a 10 min anneal under forming gas at 300 and , respectively.
Toward automatic robot instruction from perception-mapping human grasps to manipulator grasps (1997)

Our approach of programming a robot is by direct human demonstration. The system observes a human performing the task, recognizes the human grasp, and maps it onto the manipulator. This paper describes how an observed human grasp can be mapped to that of a given general-purpose manipulator for task replication. Planning the manipulator grasp based upon the observed human grasp is done at two levels: the functional and physical levels. Initially, at the functional level, grasp mapping is achieved at the virtual finger level; the virtual finger is a group of fingers acting against an object surface in a similar manner. Subsequently, at the physical level, the geometric properties of the object and manipulator are considered in fine-tuning the manipulator grasp. Our work concentrates on power or enveloping grasps and the fingertip precision grasps. We conclude by showing an example of an entire programming cycle from human demonstration to robot execution.
Multicast-aware power allocation in multiple spot-beam satellite communication systems (2006)

In this paper, we address the problem of user heterogeneity in satellite multicast from the perspective of resource allocation in a multiple spot-beam satellite system that supports both unicast and multicast flows. Satellite communication systems, with their wide-area coverage and direct access to large number of users, clearly have an inherent advantage in supporting multicast applications. In order to remain competitive against other broadband technologies, however, next generation satellite systems will be required to support both unicast and multicast flows and offer optimal sharing of system resources between these flows. We show that user heterogeneity across spot-beam queues may result in lower allocated session rates for active flows, and be perceived as unsatisfactory by potential users when both unicast and multicast flows are active in the system. We propose an optimization-based approach that allocates resources with the goal of smoothing user heterogeneity, and show that resulting session rates are higher on the average for both unicast and multicast flows. This is achieved through the re-distribution of system power among spot-beam queues, by taking into account the load on the queues and the channel states. We conclude that it is possible to increase the average session rates of multicast flows by 25–100%, and the rates of unicast flows by 15–40% compared to the pre-optimization levels. Copyright © 2006 John Wiley & Sons, Ltd.
Designing Ethical Personal Agents (2018)

The authors consider the problem of engineering ethical personal agents. Such an agent would understand the applicable social norms and its users preferences among values. It would act or recommend actions that promote preferred values, especially, in scenarios where the norms conflict.
Elevated risk of invasive group A streptococcal disease and host genetic variation in the human leukocyte antigen locus (2019)

Abstract Invasive group A streptococcal (GAS) disease is uncommon but carries a high case-fatality rate relative to other infectious diseases. Given the ubiquity of mild GAS infections, it remains unclear why healthy individuals will occasionally develop life-threatening infections, raising the possibility of host genetic predisposition. Here, we present the results of a case-control study including 43 invasive GAS cases and 1,540 controls. Using HLA imputation and linear mixed-models, we find each copy of the HLA-DQA1 *01:03 allele associates with a two-fold increased risk of disease (odds ratio 2.3, 95% confidence interval 1.3-4.4, P =0.009), an association which persists with classical HLA typing of a subset of cases and analysis with an alternative large control dataset with validated HLA data. Moreover, we propose the association is driven by the allele itself rather than the background haplotype. Overall this finding provides impetus for further investigation of the immunogenetic basis of this devastating bacterial disease.
Many-to-Many Invocation (2002)

Many-to-Many Invocation (M2MI) is a new paradigm for building collaborative systems that run in wireless proximal ad hoc networks M2MI provides an object oriented method call abstraction based on broadcasting. An M2MI invocation means "Every object out there that implements this interface, call this method." An M2MI-based application is built by defining one or more interfaces, creating objects that implement those interfaces in all the participating devices, and broadcasting method invocations to all the objects on all the devices.
In-situ investigation of the mineralization process of chitosan physical hydrogels by calcium phosphates (2016)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
Performance of Nanofiltration Membranes in Ethanol (2005)

Abstract Several nanofiltration membranes were tested for flux and rejection of selected solutes in ethanol. The membranes were initially conditioned with pure solvent containing increasing concentrations of ethanol. Flux decreased with increase in ethanol concentration and increased at higher temperatures and pressures. The type of solute had an influence on membrane rejection profiles. The DK membrane showed increasing rejection of polyethylene glycols (PEG) dissolved in ethanol from 29% at a molecular weight (MW) of 200 to 80% at MW 1000. However, the MW of sugars and lipids had little or no effect on rejection with the DK membrane; their rejection averaged 87%. In contrast, the TFC‐SR1 membrane showed higher rejections with higher MW compounds: lipid rejection increased from 19% to 71%, sugars from 35% to 85%, and lipids from 77% to 89%. The TFC‐SR2 membrane was much more open and showed the lowest rejections of all these compounds. Flux generally showed opposite trends, with the DK showing the lowest flux and the SR2 the highest.
A bridge-type resistive temperature sensor in CMOS technology with low stress sensitivity (2014)

CMOS resistive and bipolar temperature sensors are sensitive to mechanical stress via the piezoresistance and piezojunction effects. In this paper we present a CMOS compatible temperature sensor with differential output and low stress sensitivity. The sensor is based on 16 appropriately arranged p-well and p-poly resistors combined in a Wheatstone bridge in such a way as to provide isotropic piezoresistance for the sum of in-plane normal stress and to compensate the junction field effect. At room temperature the sensitivities with respect to temperature and stress were found to be 3.9mV/K and -29 uV /MPa, respectively. Hence, the sensor experiences a stress-related error as small as -0.0074K/MPa. In contrast to conventional bipolar approaches our sensor does not require any circuitry. Moreover, it can be placed easily at the desired location on the chip thanks to its small size of 61um × 61 um.
Figure S5 from Efficacy of Affibody-Based Ultrasound Molecular Imaging of Vascular B7-H3 for Breast Cancer Detection (2023)

&lt;p&gt;Characterization of MDA-MB-231/f-luc, MS1WT/r-luc, and MS1hB7-H3/r-luc cells.&lt;/p&gt;
Anti-cancer potency of tasquinimod is enhanced via albumin-binding facilitating increased uptake in the tumor microenvironment (2014)

Tasquinimod, an orally active quinoline-3-carboxamide, binds with high affinity to HDAC4 and S100A9 in cancer and infiltrating host cells within compromised tumor microenvironment inhibiting adaptive survival pathways needed for an angiogenic response. Clinical trials document that as low as 0.5-1mg tasquinimod/day is therapeutic against castrate resistant metastatic prostate cancer. Tasquinimod is metabolized via cytochrome P4503A4, but ketoconazole at a dose which completely inhibits CYP3A metabolism does not affect tasquinimod's ability to inhibit endothelial "sprouting" in vitro or anti-cancer efficacy against human prostate cancer xenografts in vivo. Tasquinimod's potency is facilitated by its reversible binding (Kd < 35 μM) to the IIA subdomain of albumin (Sudlow's site I). As blood vessels within the compromised cancer microenvironment are characterized by a higher degree of leakiness than those in normal tissues, this results in an enhanced uptake of tasquinimod bound to albumin in cancer tissue via a tumor specific process known as the "enhanced permeability and retention" (i.e., EPR) effect. Thus, despite plasma levels of < 1 µM, the EPR effect results in intracellular drug concentrations of 2-3 µM, levels several-fold higher than needed for inhibition of endothelial sprouting (IC50 ~ 0.5 µM) or for inhibition of HDAC4 and S100A9 mediated tumor growth.
Cross comparison of thin-film tensile-testing methods examined using single-crystal silicon, polysilicon, nickel, and titanium films (2005)

This paper reports on the results of comparing different types of tensile testing methods that are used to evaluate thin-film properties. We tested the same material fabricated on a single wafer using different testing techniques at five different research institutions. The testing methods were different in the way the specimen was gripped. Materials tested were single-crystal silicon (SCS), polysilicon, nickel, and titanium films. Specimens with three different shapes were processed through the same fabrication steps. The tensile strength, fracture strain, and Young's modulus of the films were measured and compared. The measured values of the mechanical properties of all the testing methods were in good agreement with each other, thus demonstrating their accuracy.
Redox modulatory site of the NMDA receptor–channel complex: Regulation by oxidized glutathione (1991)

We monitored increases in both intracellular calcium concentration [( Ca2+]i) and whole-cell current responses induced by N-methyl-D-aspartate (NMDA), applied with co-agonist glycine, using fura-2 digital imaging and patch-clamp recording techniques. Extracellular application of oxidized glutathione (GSSG), but not reduced glutathione (GSH), inhibited responses mediated by activation of the NMDA subtype of glutamate receptor in cultures of rat cortical and retinal ganglion cell neurons. The NMDA responses were persistently inhibited by GSSG (500 microM to 10 mM) until introduction of a selective sulfhydryl reducing agent, dithiothreitol, which resulted in complete recovery of the responses. Exposure of the neurons to 5,5-dithio-bis-2-nitrobenzoic acid (DTNB), an efficacious oxidizing agent, also resulted in persistently smaller responses to NMDA. The addition of GSSG following exposure to DTNB, however, did not result in a further decrement in NMDA responses in our experimental paradigm. These findings suggest that a predominant action of GSSG is oxidation of vicinal thiol groups to form a peptide disulfide bond(s) comprising the redox modulatory site of the NMDA receptor-channel complex. Evidence for such regulatory sulfhydryl centers associated with the NMDA receptor has been presented previously. Moreover, the fact that DTNB produced little if any additional attenuation of the NMDA [Ca2+]i response when administered after GSSG implies that GSSG is also an efficacious oxidant at this site. GSSG displayed little or no effect on [Ca2+]i responses elicited by high extracellular K+ or by kainate, suggesting that, at least under the conditions of the present experiments, GSSG was somewhat selective for the NMDA redox modulatory site. Based on these observations, we suggest that GSSG exerts its NMDA-specific redox effects in a novel extracellular manner.
A Bioluminogenic HDAC Activity Assay: Validation and Screening (2011)

Histone deacetylase (HDAC) enzymes modify the acetylation state of histones and other important proteins. Aberrant HDAC enzyme function has been implicated in many diseases, and the discovery and development of drugs targeting these enzymes is becoming increasingly important. In this article, the authors report the evaluation of homogeneous, single-addition, bioluminogenic HDAC enzyme activity assays that offer less assay interference by compounds in comparison to fluorescence-based formats. The authors assessed the key operational assay properties including sensitivity, scalability, reproducibility, signal stability, robustness (Z'), DMSO tolerance, and pharmacological response to standard inhibitors against HDAC-1, HDAC-3/NcoR2, HDAC-6, and SIRT-1 enzymes. These assays were successfully miniaturized to a 10 µL assay volume, and their suitability for high-throughput screening was tested in validation experiments using 640 drugs approved by the Food and Drug Administration and the Hypha Discovery MycoDiverse natural products library, which is a collection of 10 049 extracts and fractions from fermentations of higher fungi and contains compounds that are of low molecular weight and wide chemical diversity. Both of these screening campaigns confirmed that the bioluminogenic assay was high-throughput screening compatible and yielded acceptable performance in confirmation, counter, and compound/extract and fraction concentration-response assays.
Natural and synthetic small molecule inhibitors of a phage-encoded quorum-sensing receptor affect phage-host dynamics in mixed bacterial communities (2022)

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