gebhart/patrepeval huggingface dataset:
Establishing multimodal telepresence sessions using the Session Initiation Protocol (SIP) and advanced haptic codecs (2010)

In telepresence and telemanipulation systems, multimodal data is exchanged over a network allowing humans to experience and to operate in remote or inaccessible environments. To operate over the global Internet and connect to multiple telepresence systems, a flexible framework for initiating, handling and terminating Internet-based telerobotic sessions becomes necessary. In this work, we explore the use of standard Internet session and transport protocols in the context of telerobotic applications. Session Initiation Protocol (SIP) is widely used to handle multimedia teleconference sessions with audio, video or text, and provides many services advantageous for establishing connections between heterogeneous haptic interfaces and telerobotic systems. We apply the session paradigm to the creation and negotiation of haptic telepresence sessions and propose to extend this framework to work with the haptic modality. The notion of a ¿haptic codec¿ is introduced for transforming haptic data into a common format, applying data reduction or compression techniques and implementing teleoperation control architectures. The use of the Real-Time Transport Protocol (RTP) is explored for transport of teleoperation data. Finally, a prototype and demonstrator system is presented for evaluation of the proposed framework.
Evolution and decay of an Alice ring in a spinor Bose-Einstein condensate (2023)

We use first-principles-derived numerical simulations to investigate the long-time evolution of a half-quantum vortex ring, an Alice ring, arising from the decay dynamics of an isolated monopole in the polar phase of a dilute spin-1 Bose-Einstein condensate. In particular, we study the lifetime and decay characteristics of the Alice ring under different experimentally relevant conditions. We observe that, in a $^{87}\mathrm{Rb}$ condensate with a homogeneous external magnetic field, a well-centered Alice ring may survive for over 160 ms, and that during its lifetime it can contract back into a monopole, which again converts into an Alice ring. Interestingly, we notice an additional Alice ring, with an opposite topological charge, to emerge during the decay dynamics within the condensate, leading to the coexistence of two Alice rings in the same cloud. Shortly after this coexistence, the original Alice ring breaks into a line-like defect referred to as an Alice string. We find that the location of the initial isolated monopole correlates with the winding direction of the scalar phase in the produced vortex ring, a phenomenon which we utilize to create two Alice rings with opposite charges and opposite winding directions. Such created Alice ring and anti-Alice ring naturally annihilate each other in the subsequent evolution.
Indistinguishable single photons from a quantum dot (2003)

Abstract We report a set of experiments designed to test the quantum indistinguishability of single photons emitted by a resonantly pumped InAs/GaAs quantum dot, embedded in a microcavity. We first performed high resolution interferometric measurements on the source to infer its coherence time. By comparison with the exciton lifetime, obtained by time‐resolved spectroscopy, we found that some quantum dots were emitting almost transform‐limited photons. The measured ratio of the coherence time to the pulse duration gives a lower bound on the dephasing time which agrees well with previous studies. We then directly measured the mean overlap between wave packets of consecutive photons emitted 2 ns apart, through a Hong–Ou–Mandel type two‐photon interference experiment. For the best dot, an overlap as high as 0.81 was inferred. This result suggests that quantum dots could be a practical single photon source to perform quantum information processing experiments. We stress the importance of the microcavity for identical photon generation.
Advanced photonic hybrid nanostructures based on plasmonic nanophotopolymerization (2014)

International audience
Pacemaker‐Mediated Programmable Hypertension Control Therapy (2017)

URL: http://www.clinicaltrials.gov. Unique identifier: NCT02282033.
Optically controlled electroabsorption modulators for unconstrained wavelength conversion (2004)

We introduce a proof-of-concept, optically controlled, optical switch based on the monolithic integration of a surface-illuminated photodetector and a waveguide electroabsorption modulator. We demonstrate unconstrained wavelength conversion over the entire center telecommunication wavelength band (C band) and optical switching up to 2.5 Gbit/s with extinction ratios exceeding 10 dB. Our approach offers both high-speed, low-power, switching operation and two-dimensional array scalability for the fabrication of chip-scale reconfigurable multichannel wavelength converters.
Einfache stereoselektive Synthese von Eburnamonin (1977)

Die regioselektive Ringöffnung des Cyclopropanderivats ( 1 ), R = C 2 H 5 , ist der Schlüsselschritt bei der Synthese des Vincamin‐Alkaloids Eburnamonin ( 2 ). Bei ( 2 ) repräsentiert die cis ‐D,C‐Verknüpfung das entscheidende stereochemische Problem in dieser Serie. magnified image
Characterization of concurrent ovarian and endometrial carcinoma by copy-number analysis (CNA) and gene expression profiling (GEP) (2007)

10546 Background: Coexistence of endometrioid carcinoma at both sites, the ovary and the endometrium, is between 10–30%. Current staging relies on clinical and pathologic assessment, which is not quantitative and highly subjective. The objective of this study was to evaluate archived tissues from patients with concurrent tumors for CNA and GEP, and determine if either or both of these techniques could be used to define the primary site of the endometroid carcinoma. Methods: A gynecologic pathologist confirmed that all specimens from both sites were of endometrioid histology; grades I/II. CNA was determined by extracting DNA from both disease and non-disease tissues for hybridization to the Affymetrix 500K SNP microarrays. Illumina HumanRef8 BeadChip microarrays were used throughout to obtain GEP for 7 endometrial and 7 ovarian primary stage I tumor samples. Differentially expressed genes between both groups created a corresponding discrimination scores (DS). The performance of the discrimination scores were evaluated by the Leave-One-Out method. In a similar fashion, a test set of 16 tumor samples from patients with concurrent tumors were profiled. The prediction of these tumors’ origin based on the DS were compared with pathological assessment and copy number analysis. Results: Concurrent tumors display more copy number changes than singular tumors of either tissue, with a greater fraction of the genome involved. Analysis of the non-affected tissue assists in identifying tumor-specific changes. We identified a set of 30 differentially expressed genes between both ovarian and endometrial tumors that discriminates a tumors’ origin with about 80% confidence. For patients with concurrent tumors, comparison of their origin based on GEP, CNA, and pathological assessment shows limited concordance. Conclusion: Shared somatic copy number changes in simultaneous endometrioid carcinomas of the ovary and endometrium indicate a common origin and hence metastasis. For these relatively common concurrent tumors, clinical inferences based on CNA appear more robust than those based on GEP, and more objective than pathological assessment. No significant financial relationships to disclose.
New Developments in Defect Studies in Semiconductors (1976)

The purpose of this work is to report significant new results in defect studies and indicate the impact of these ideas on today's problems. 13 figs, 2 tables, 49 refs.
Panoramic Background Estimation from RGB-D Videos (2017)

We propose a novel hybrid framework for estimating a clean panoramic background from consumer RGB-D cameras. The method explicitly handles moving objects, eliminates distortions observed in traditional 2D stitching methods and adaptively handles errors in input depth maps to avoid errors common in 3D based schemes. It produces a panoramic output which integrates parts of the scene as captured from the different poses of the moving camera and removes moving objects by replacing them with their correct background information in color and depth. A fused and cleaned RGB-D has multiple applications such as virtual reality, video compositing and creative video editing. Existing image stitching methods rely on either color or depth information and thus suffer from perspective distortions or low RGB fidelity. A detailed comparison between traditional and state-of-the-art methods and the proposed framework demonstrates the advantages of fusing 2D and 3D information for panoramic background estimation.
Raman and fluorescence correlative microscopy in polarized light to probe local femtosecond laser-induced amorphization of the doped monoclinic crystal LYB:Eu (2013)

International audience
Abstract 2645: Advantages of polyacetal polymer-based ADCs: Application to low expression targets (2014)

Abstract The application of biodegradable polymers to antibody-drug conjugate (ADC) design can provide numerous advantages, including significantly higher drug-antibody ratios, the use of alternative payloads with potencies considered insufficient for direct conjugation, the improvement of ADC physico-chemical properties, especially for highly hydrophobic payloads, and the potential expansion of protein recognition scaffolds beyond the commonly used IgGs. The basis of the novel polymer-based conjugation system described herein is a hydrophilic, fully biodegradable polyacetal carrier, (poly(1-hydroxymethylethylene hydroxymethylformal) or PHF) modified with chemically orthogonal linkers. A bioconjugation linker is used for efficient covalent attachment of a targeting moiety to the PHF scaffold, while a second, chemically distinct linker is used to attach multiple copies of a drug payload to the polymer to control the mechanism and rate of drug release. Utilizing multiple copies of a proprietary dolastatin derivative chemically conjugated to PHF, we have developed a potent and effective drug conjugation platform for ADC application, which has been named Dolaflexin™. Here, we report the preparation and characterization of a novel trastuzumab DolaflexinTM ADC, employing a maleimide-based bioconjugation approach. The resulting ADC, with a drug-antibody ratio of 20, exhibits enhanced stability and improved pharmacokinetics, with a prolonged plasma half-life and tumor-specific accumulation. Active drug release and accumulation in tumor tissue was also confirmed by LC/MS/MS methods. The activity of this novel trastuzumab-dolaflexin ADC was evaluated in multiple tumor xenograft models with significant variations in target antigen expression levels. Models including BT474 breast cancer, NCI-N87 gastric cancer, and JIMT1 breast cancer models were utilized, and comparisons to a variety of controls and ADC reference standards were made. Significant advantages of the polyacetal polymer-based ADCs in comparison to conventional ADCs, particularly in models with low target antigen expression, were observed. Details of these studies and potential applications for the development of new ADC therapeutics based on this approach will be presented. Citation Format: Alex Yurkovetskiy, Natalya Bodyak, Mao Yin, Joshua D. Thomas, Patrick Conlon, Cheri A. Stevenson, Alex Uttard, LiuLiang Qin, Dmitry R. Gumerov, Elena Ter-Ovaneysan, Venu R. Gurijala, Dennis McGillicuddy, Roberta E. Glynn, Michael DeVit, Laura L. Poling, Peter U. Park, Timothy B. Lowinger. Advantages of polyacetal polymer-based ADCs: Application to low expression targets. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2645. doi:10.1158/1538-7445.AM2014-2645
Supplemental Table from Early Pregnancy Sex Steroids and Maternal Breast Cancer: A Nested Case–Control Study (2023)

&lt;p&gt;Doubling of Circulating Endogenous Hormones and Breast Cancer Risk, by Time Between First Birth and Diagnosis and Age at Diagnosis: Finnish Maternity Cohort (n=3,480).&lt;/p&gt;
VoIP call over WLAN with Bluetooth headset - multiradio interoperability solutions (2006)

The local wireless networking techniques are becoming more and more popular in mobile terminals nowadays. Even so that wireless LAN (e.g. IEEE 802.11b) and Bluetooth solutions operating at the 2.4 GHz ISM band can be found in the same device. This enables new kind of usage possibilities and applications from which the most challenging ones, from interoperability point of view, are those that require simultaneous real-time operation over these links. One good example of this kind of service is a voice over IP (VoIP) call over the WLAN to the terminal with a Bluetooth headset. In this paper problems regarding different receiver architectures are presented and solutions for optimized Bluetooth usage are considered
Challenges and emerging trends in liquid chromatography-based analyses of mRNA pharmaceuticals (2022)

Lipid encapsulated messenger RNA (LNP mRNA) has garnered a significant amount of interest from the pharmaceutical industry and general public alike. This attention has been catalyzed by the clinical success of LNP mRNA for SARS-CoV-2 vaccination as well as future promises that might be fulfilled by the biotechnology pipeline, such as the in vivo delivery of a CRISPR/Cas9 complex that can edit patient cells to reduce levels of low-density lipoprotein. LNP mRNAs are comprised of various chemically diverse molecules brought together in a sophisticated intermolecular complex. This can make it challenging to achieve thorough analytical characterization. Nevertheless, liquid chromatography is becoming an increasingly relied upon technique for LNP mRNA analyses. Although there have been significant advances in all types of LNP mRNA analyses, this review focuses on recent developments and the possibilities of applying anion exchange (AEX) and ion pairing reversed phase (IP-RP) liquid chromatography for intact mRNAs as well as techniques for oligo mapping analysis, 5' endcap testing and lipid compositional assays.
Development of a dual-detector system based on a-Si:H arrays and multi-element silicon detectors for diffraction-enhanced breast imaging (2002)

X-ray diffraction analysis of normal and diseased breast tissue specimens as well as cell lines proved that there are significant differences in measured spectra, if cancer is present, enabling us to quantify the various clinical conditions enhancing diagnosis. It was also demonstrated that the stereoscopic presentation of images of breast samples obtained by an a-Si:H-based digital imaging system provides important additional information and has potential benefits over the more traditional two-dimensional (2-D) data. Work is currently under way to build a prototype stereoscopic digital dual-sensor breast imaging system to evaluate the potential of diffraction-enhanced imaging approach and the likely increased detectability offered by this technique in comparison with current breast imaging modalities.
On the validity of the first-pass binding model for quantitative ultrasound molecular imaging: Comparison between BR55 and Sonovue (2017)

Cancer growth requires angiogenesis; imaging of angiogenesis may thus improve cancer diagnostics and therapy monitoring. Dynamic contrast enhanced ultrasound (DCE-US) permits imaging angiogenesis at the molecular level by using novel targeted ultrasound contrast agents (tUCA). These agents consist of functionalized microbubbles obtained by engineering the shell with targeting ligands able to bind specific biomarkers, over-expressed in tumor angiogenic vasculature. Quantification of binding may thus provide an indirect way of quantifying angiogenesis. Recently, we proposed the first-pass binding (FPB) model to describe the binding kinetics of tUCA. Fitting DCE-US time-intensity curves (TICs) by the FPB model enables quantification of binding by the estimation of the binding rate K <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">b</sub> [1]. After showing the feasibility of the method for angiogenesis imaging in prostate-tumor bearing rats [1], and performing a preliminary validation for anti-angiogenesis therapy monitoring in colon cancer-bearing mice [2], in this work we investigate the validity of the proposed model by comparing K <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">b</sub> estimates in rats injected with non-targeted UCAs (Sonovue) and tUCAs (BR55).
Dynamic Modeling and Simulation of Snowplow: Normal Operation and Icepack Impacts (2000)

Keywords: Dynamic Modeling, Snowplows, Multi-Unit Vehicles, Icepack Impacts, Braking Control, Steering Control.
Isothermal Crystallization of Nylon-6/Montmorillonite Nanocomposites (2004)

The isothermal crystallization of in-situ-polymerized and melt-processed nylon-6/montmorillonite nanocomposites was studied by simultaneous small- and wide-angle X-ray scattering using synchrotron radiation. The isothermal crystallization rates, in the nucleation-controlled regime, for the nanocomposites are significantly faster than that for the pristine nylon-6 and suggest that the layered silicates act as nucleating centers. Within the experimental resolution, the initial crystal phase formed between 185 and 205 °C in the presence of the layered silicate is the metastable γ-phase, whereas the α-phase develops in the pristine nylon-6 at comparable temperatures. Additionally, the strong silicate−polymer interactions present in the in-situ-polymerized nanocomposites alter the crystallization process, creating a much weaker temperature dependence for the crystallization kinetics. Finally, the presence of well-dispersed layered silicates significantly disrupts the development of lamellar structure but does not alter the overall amounts of crystallinity.
Cover Picture: Chemical Technologies for Exploiting and Recycling Carbon Dioxide into the Value Chain (ChemSusChem 9/2011) (2011)

Carbon dioxide, a renewable resource: The cover illustrates the vision of utilizing the greenhouse gas CO2 as feedstock for chemical production. With the implementation of carbon capture technologies, CO2 will become available in vast quantities as an economically attractive resource. On condition that an adequate supply of energy from non-fossil resources for chemical processing is ensured, the use of this CO2 would harvest nature's carbon resources most directly, without the by-pass via biomass or fossil resources and could open up a complementary strategy contributing to a closed anthropogenic carbon cycle. In a Review on page 1216, Leitner and Müller et al. discuss strategies to identify the most interesting products and chemical pathways for the utilization of CO2. The cover image was prepared by Thorsten Groetker (FairyDustInc).
Isolation, Solubilization, Refolding, and Chromatographic Purification of Human Growth Hormone from Inclusion Bodies of <I>Escherichia coli</I> Cells: A Case Study<I> (2005)

Inclusion bodies produced in Escherichia coli are composed of densely packed denatured protein molecules in the form of particles (1,2). In addition to the recombinant protein of interest, inclusion bodies contain small amounts of host protein, ribosomal components, and DNA/RNA fragments (3). It is advisable to purify the inclusion bodies from the cells to a high-degree purity before carrying out solubilization and purification. This will reduce the number of purification steps after solubilization and refolding, minimize the interference of other contaminating proteins during refolding, and result in a therapeutic protein free from other cellular contaminants, such as lipids, carbohydrate, and endotoxin (4). Isolation of inclusion bodies from E. coli occurs by cell lysis with high-pressure disruption using a French press or sonication step followed by centrifugation (5). Further purification can be achieved by washing with detergents and a low concentration of salt and/or urea (5,6). The presence of contaminants, along with the protein of interest, is mainly because of incomplete purification of the inclusion bodies following cell lysis. With proper centrifugation and washing processes, more than 95% pure inclusion bodies of recombinant proteins can be isolated from E. coli cells (7). As the inclusion bodies have a high density (approx 1.3 mg mL−1), these are easily separated by high-speed centrifugation after cell disruption (8). Centrifugal isolation, particularly sucrose gradient centrifugation, has been found to be the best method for isolating very pure inclusion bodies from E. coli cell lysate (9). Expression of recombinant human growth hormone (r-hGH) in E. coli will illustrate the methods used for isolation and purification of intact inclusion bodies. The purified inclusion bodies will then be used for solubilization and refolding to obtain bioactive protein.
Particle Size of X‐ray Pumped UVC‐Emitting Nanoparticles Defines Intracellular Localization and Biological Activity Against Cancer Cells (2020)

Abstract Effectiveness of radiation treatment for cancer is limited in hypoxic tumors. Previous data shows that UVC‐emitting nanoparticles enhance cytotoxicity of X‐ray irradiation in hypoxic tumor cells. This study examines the impact on cell killing, particle size, uptake into cells, incubation time, and UV emission intensity of LuPO 4 :Pr 3+ ,Nd 3+ . A549 cells are treated with LuPO 4 :Pr 3+ ,Nd 3+ and X‐rays. The surviving fraction is evaluated using the colony formation assay after treatment of cells with different particle sizes ( D 50 = 0.16 and 5.05 µm) and after different incubation times before X‐ray irradiation. Nanoparticle uptake into cells is verified by transmission electron microscopy and quantified by inductively coupled plasma mass spectrometry. The microparticles exhibit a five times higher emission intensity compared to nanoparticles. Both particle sizes show an increased cytotoxic effect after X‐ray excitation with prolonged incubation times. Surprisingly, the smaller nanoparticles show a significantly higher biological effect compared to the larger particles, despite their significantly lower UVC emission. Nanoparticles accumulate more quickly and closer to the nucleus than the microparticles, resulting in higher localized UVC emission and greater lethality. The results suggest that the number of intracellular particles and their proximity to the cell DNA is more important than the emission intensity of the particles.
2305 A Development of the Fall Detection Sensor on the Escalator Exits (2010)

The disaster at escalator exits draws great attention. This paper proposes a fall detection sensor on the escalator exits. The sensor watches surveillance area with infrared laser, and measures the object position and decides the fall by size and time. Fall detection algorithm finds falling human within 5 seconds while suppresses false alarm caused by crowded people, and send the message to security room. This paper describes the construction and principle of operation, and demonstrates its availability.