gebhart/patrepeval huggingface dataset:
Multiobjective Design and Benchmark of Wide Voltage Range Phase Shift Full-Bridge DC/DC Converters for EV Charging Application (2023)

This article presents an analysis, multiobjective design, and benchmark of three modified 3 phase shift full-bridge (PSFB) converters that are well-suited for electric vehicle (EV) battery charging applications, covering both typical battery voltage classes (400 and 800 V). These three modified PSFB converters, denoted as the t-PSFB, r-PSFB, and i-PSFB converters, have the ability to reconfigure and provide better efficiency performance in the wide voltage range necessary for public EV battery charging applications. In this article, the characteristics and design considerations of these reconfigurable PSFB converters are discussed in detail. A multiobjective converter design process is proposed to optimize the average efficiency, normalized cost, and power density of the magnetic components and heat sinks. This design process employs the correlations between the cost and performance indexes of the key components derived based on open and accessible components’ data to estimate the design objectives. In this way, the design process is not constrained by certain component choices, making it easier to identify the most advantageous design. A benchmark study is conducted among the reconfigurable PSFB topologies and the conventional PSFB circuit using the proposed multiobjective design process. To validate the analysis, a close-to-Pareto-front 11-kW, 45-kHz r-PSFB converter prototype with 640–840-V input voltage and 250–1000-V output voltage ranges is developed and tested.
Exposures Exposed: A Measurement and User Study to Assess Mobile Data\n Privacy in Context (2020)

Mobile devices have access to personal, potentially sensitive data, and there\nis a large number of mobile applications and third-party libraries that\ntransmit this information over the network to remote servers (including app\ndeveloper servers and third party servers). In this paper, we are interested in\nbetter understanding of not just the extent of personally identifiable\ninformation (PII) exposure, but also its context i.e., functionality of the\napp, destination server, encryption used, etc.) and the risk perceived by\nmobile users today. To that end we take two steps. First, we perform a\nmeasurement study: we collect a new dataset via manual and automatic testing\nand capture the exposure of 16 PII types from 400 most popular Android apps. We\nanalyze these exposures and provide insights into the extent and patterns of\nmobile apps sharing PII, which can be later used for prediction and prevention.\nSecond, we perform a user study with 220 participants on Amazon Mechanical\nTurk: we summarize the results of the measurement study in categories, present\nthem in a realistic context, and assess users' understanding, concern, and\nwillingness to take action. To the best of our knowledge, our user study is the\nfirst to collect and analyze user input in such fine granularity and on actual\n(not just potential or permitted) privacy exposures on mobile devices. Although\nmany users did not initially understand the full implications of their PII\nbeing exposed, after being better informed through the study, they became\nappreciative and interested in better privacy practices.\n
Restoration of ASC expression sensitizes colorectal cancer cells to genotoxic stress-induced caspase-independent cell death (2013)

Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), an essential component of the inflammasome complex, is frequently silenced by epigenetic methylation in many tumor cells. Here, we demonstrate that restoration of ASC expression in human colorectal cancer DLD-1 cells, in which ASC is silenced by aberrant methylation, potentiated cell death mediated by DNA damaging agent. Contrarily, ASC knockdown in HT-29 cells rendered cells less susceptible to etoposide toxicity. The increased susceptibility of ASC-expressing DLD-1 cells to genotoxic stress was independent of inflammasome or caspase activation, but partially dependent on mitochondrial ROS production and JNK activation. Thus, our data suggest that ASC expression in cancer cells is an important factor in determining their susceptibility to chemotherapy.
9.1 A resistor-based temperature sensor with a 0.13pJ·K2 resolution FOM (2017)

Temperature sensors are often used for the temperature compensation of frequency references [1–5]. High resolution and energy efficiency are then critical requirements, the former to minimize jitter and the latter to minimize power dissipation in a given conversion time. A MEMS-resonator-based sensor meets both criteria [1], but requires two resonators. In principle, resistor-based sensors also meet these criteria, and are CMOS compatible, but previous designs have been limited by the power dissipation [2–4] or 1/f noise [6] of their readout electronics. This paper describes a CMOS temperature sensor that digitizes the temperature-dependent phase shift of an RC filter. It achieves 410µK <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</inf> resolution in a 5ms conversion time, while consuming only 160µW. This corresponds to a resolution FOM of 0.13pJ·K <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , a 5× improvement on previous CMOS sensors [6].
Measurement and modeling of multiuser multiantenna system in aircraft in the presence of electromagnetic noise and interference (2011)

Abstract This article evaluates the accuracy with which the performance of a multiuser multiantenna system can be predicted with and without considering cochannel interference and noise (Gaussian, α‐stable, and Cauchy) using a site‐specific three‐dimensional (3D) ray tracing algorithm as well as with statistical models with Gaussian and Nakagami‐m channel models in small to medium sized aircraft. These models expand on previous statistical channel models such as the hyper‐Rayleigh model by including the simultaneous effects of cochannel and adjacent channel interference, antenna matching, efficiency, directivity and polarization as well as (for the 3D model) site‐specific multipath effects. Measurements and comparisons are made in a metallic‐bodied Beech Baron BE 58P and a composite structure Rockwell T‐39 Sabreliner. It was found that the 3D ray tracing model provides a mean capacity within 1% of those measured in the two aircraft in the presence of interference and noise. This was closely followed by the Nakagami‐m distribution (m = 1.4), which was within 1–3% of measured capacity in the presence of interference and within 6% for a combination of interference and noise and the Gaussian model which was within 6% of measured capacity in the presence of interference and within 11% for a combination of interference and noise. The Cauchy noise degraded the capacity more than the other types of noise in the aircraft, providing a lower bound for capacity in an aircraft system. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:1137–1144, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25939
Microscale Location, Characterization, and Association of Polycyclic Aromatic Hydrocarbons on Harbor Sediment Particles (2000)

Complementary mass spectrometric and spectroscopic techniques were employed to provide direct information at the microscale on the sequestration of polycyclic aromatic hydrocarbon (PAH) contaminants in Milwaukee Harbor sediment particles. Microprobe two-step laser desorption/laser ionization mass spectrometry was used for PAH measurements, infrared microspectroscopy was used for organic carbon measurement, and scanning electron microscopy with wavelength dispersive X-ray spectroscopy was used for elemental microanalysis. PAH concentrations on coal- and wood-derived particles were found to be several orders of magnitude higher than on silica particles. A cryomicrotome sectioning procedure was employed for particle cross-sectional investigations, and it was found that most PAHs are concentrated on external surface regions indicating near surface sorption mechanisms. The coal/wood-derived particles constitute only 5% of the sediment by weight but contain 62% of the total PAHs. The remaining 38% are mainly in a clay and silt fraction. PAH desorption kinetic studies on these separated fractions revealed a relatively low availability of PAHs from the coal/wood fractions and a high availability from the clay/silt fraction. Additionally, these PAH-bearing coal/wood-derived particles may be removed by density separation from heavier clay, silt, and sand.
Long-term survival in patients undergoing cardiac resynchronization therapy: the importance of performing atrio-ventricular junction ablation in patients with permanent atrial fibrillation (2008)

Patients with HF and AF treated with CRT have similar mortality compared with patients in SR. In AF, AVJ ablation in addition to CRT significantly improves overall survival compared with CRT alone, primarily by reducing HF death.
Cell Death and Ionic Regulation Detection with Digital Holographic Microscopy (2011)

We demonstrate the capability of digital holographic microscopy to detect cell death through the measurement of volume regulation, considered as an early indicator of cellular deregulation, leading to cell death, and link it with calcium homeostasis.
Optical synchronization system for femtosecond X-ray sources (2023)

Femtosecond pump/probe experiments using short X-Ray and optical pulses require precise synchronization between 100 meter-10 km separated lasers in a various experiments. For stabilization in the hundred femtosecond range a CW laser is amplitude modulated at 1-10 GHz, the signal retroreflected from the far end, and the relative phase used to correct the transit time with various implementations. For the sub-10 fsec range the laser frequency itself is upshifted 55 MHz with an acousto-optical modulator, retroreflected, upshifted again and phase compared at the sending end to a 110 MHz reference. Initial experiments indicate less than 1 fsec timing jitter. To lock lasers in the sub-10 fs range two single-frequency lasers separated by several teraHertz will be lock to a master modelocked fiber laser, transmit the two frequencies over fiber, and lock two comb lines of a slave laser to these frequencies, thus synchronizing the two modelocked laser envelopes.
Design for enhanced solder joint reliability of integrated passives device under board level drop test and thermal cycling test (2004)

The integrated passives device (IPD) is an advanced substrate with embedded passives. The device is mounted to the board with lead-free solder joints. Detailed solder joint reliability models are established for both drop test and thermal cycling test for IPD packages. For drop test, the critical solder joints are observed along the outermost row in the PCB length direction. For thermal cycling test, the critical solder joint is observed at the outermost package corner, with possible failure along the solder/IPD pad interface. The distance to neutral point effect is dominant for IPD structures under drop test and thermal cycling tests. However, drop test performance is more dependent on PCB geometry, compared with the thermal cycling test. Drop test and thermal cycling test have different failure mechanisms and distinct failure modes.
Wireless temperature sensor for gas turbine engine applications (2010)

A passive wireless sensor has been developed that requires no power to operate and.........that has ideal characteristics for remote temperature sensing This wireless temperature sensor was designed to withstand the harsh environment of the hot section in turbine engines WTS is particularly useful in applications where the surface temperature of rotating components is desired and where the routing wires to a data acquisition system to complete the measurement is too difficult or complex.
Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal Healing (2023)

The paracaspase MALT1 is a crucial regulator of immune responses in various cellular contexts. Recently, there is increasing evidence suggesting that MALT1 might represent a novel key player in mucosal inflammation. However, the molecular mechanisms underlying this process and the targeted cell population remain unclear. In this study, we investigate the role of MALT1 proteolytic activity in the context of mucosal inflammation. We demonstrate a significant enrichment of MALT1 gene and protein expression in colonic epithelial cells of UC patients, as well as in the context of experimental colitis. Mechanistically we demonstrate that MALT1 protease function inhibits ferroptosis, a form of iron-dependent cell death, upstream of NF-κB signaling, which can promote inflammation and tissue damage in IBD. We further show that MALT1 activity contributes to STAT3 signaling, which is essential for the regeneration of the intestinal epithelium after injury. In summary, our data strongly suggests that the protease function of MALT1 plays a critical role in the regulation of immune and inflammatory responses, as well as mucosal healing. Understanding the mechanisms by which MALT1 protease function regulates these processes may offer novel therapeutic targets for the treatment of IBD and other inflammatory diseases.
KNN-LM Does Not Improve Open-ended Text Generation (2023)

In this paper, we study the generation quality of interpolation-based retrieval-augmented language models (LMs). These methods, best exemplified by the KNN-LM, interpolate the LM's predicted distribution of the next word with a distribution formed from the most relevant retrievals for a given prefix. While the KNN-LM and related methods yield impressive decreases in perplexity, we discover that they do not exhibit corresponding improvements in open-ended generation quality, as measured by both automatic evaluation metrics (e.g., MAUVE) and human evaluations. Digging deeper, we find that interpolating with a retrieval distribution actually increases perplexity compared to a baseline Transformer LM for the majority of tokens in the WikiText-103 test set, even though the overall perplexity is lower due to a smaller number of tokens for which perplexity dramatically decreases after interpolation. However, when decoding a long sequence at inference time, significant improvements on this smaller subset of tokens are washed out by slightly worse predictions on most tokens. Furthermore, we discover that the entropy of the retrieval distribution increases faster than that of the base LM as the generated sequence becomes longer, which indicates that retrieval is less reliable when using model-generated text as queries (i.e., is subject to exposure bias). We hope that our analysis spurs future work on improved decoding algorithms and interpolation strategies for retrieval-augmented language models.
Automatic classification of security messages based on text categorization (2008)

The generated messages by the security devices are the necessary data for the detection of the malicious activities in an information system. The heterogeneity of the devices and the lack of a standard for the security messages make the automatic processing of the messages difficult. The messages are short, use a very wide vocabulary and have different formats. We propose in this article the application of the text categorization technics for the automatic classification of security log files messages, in categories defined by an ontology. We develop an extraction module for the message attributes to reduce the vocabulary size. Then we apply two training algorithms: the k-nearest neighbour algorithm and the naive bayes, on two corpus of security log messages.
Acetophenetidin Nephritis and Papillary Necrosis (1964)

Before 1960 the association of interstitial nephritis and papillary necrosis with the chronic ingestion of kilogram quantities of acetophenetidin (Phenacetin) was described almost exclusively by Swiss and Scandinavian authors. Since that date a number of authors outside of Europe have drawn attention to the possible effects of acetophenetidin, and in all probability the condition is not as rare in other countries as was formerly believed. At present there is a great deal of controversy concerning various aspects of the relationship of acetophenetidin ingestion and renal disease. Thus, the exact role of acetophenetidin or its degradation products in the production of renal lesions is uncertain<sup>1</sup>; the importance of the different methods of manufacture of acetophenetidin and the resulting contaminating compounds in the pathogenesis of the renal disease is being debated<sup>2</sup>; the specificity of the histological picture produced by prolonged ingestion of acetophenetidin is open to doubt<sup>3,4</sup>; the role
Multi-objective optimization and comparative evaluation of Si soft-switched and SiC hard-switched automotive DC-DC converters (2009)

The application of soft-switching concepts or silicon carbide (SiC) devices are two enabling technologies to further push the efficiency, power density or specific weight of power electronics converters. For an automotive application, such as a DC-DC converter that interconnects the high voltage battery or ultra-capacitor in a hybrid electrical vehicle (HEV) or a fuel cell vehicle (FCV) to the DC-link, costs and failure rate are likewise of importance. Due to increasing requirements on multiple of these converter characteristics the comprehensive multi-objective optimization of the entire converter system gains importance. Thereto, this paper proposes an optimization method to explore the limits of power density as a function of the switching frequency and the number of phases of non-isolated bi-directional multi-phase DC-DC converters operated with soft-switching and silicon devices and hard-switched converters that take advantage of SiC devices. In addition, the optimization includes an algorithm to determine the chip size required for the semiconductor devices under consideration of the thermal characteristics and efficiency requirements. Based on detailed analytical volume, loss and cost models of the converter components as well as on measurements demonstrative results on the optimum converter designs are provided and evaluated comparatively for the different converter concepts.
High-throughput screening with micro-x-ray fluorescence (2005)

Micro-x-ray fluorescence (MXRF) is a useful characterization tool for high-throughput screening of combinatorial libraries. Due to the increasing threat of use of chemical warfare (CW) agents both in military actions and against civilians by terrorist extremists, there is a strong push to improve existing methods and develop means for the detection of a broad spectrum of CW agents in a minimal amount of time to increase national security. This paper describes a combinatorial high-throughput screening technique for CW receptor discovery to aid in sensor development. MXRF can screen materials for elemental composition at the mesoscale level (tens to hundreds of micrometers). The key aspect of this work is the use of commercial MXRF instrumentation coupled with the inherent heteroatom elements within the target molecules of the combinatorial reaction to provide rapid and specific identification of lead species. The method is demonstrated by screening an 11-mer oligopeptide library for selective binding of the degradation products of the nerve agent VX. The identified oligopeptides can be used as selective molecular receptors for sensor development. The MXRF screening method is nondestructive, requires minimal sample preparation or special tags for analysis, and the screening time depends on the desired sensitivity.
Murine Models of Hepatitis A Virus Infection (2018)

Mechanistic analyses of hepatitis A virus (HAV)-induced pathogenesis have long been thwarted by the lack of tractable small animal models that recapitulate disease observed in humans. Several approaches have shown success, including infection of chimeric mice with human liver cells. Other recent studies show that HAV can replicate to high titer in mice lacking expression of the type I interferon (IFN) receptor (IFN-α/β receptor) or mitochondrial antiviral signaling (MAVS) protein. Mice deficient in the IFN receptor show critical features of type A hepatitis in humans when challenged with human HAV, including histological evidence of liver damage, leukocyte infiltration, and the release of liver enzymes into blood. Acute pathogenesis is caused by MAVS-dependent signaling that leads to intrinsic apoptosis of hepatocytes.
Application-controlled physical memory using external page-cache management (1992)

article Free Access Share on Application-controlled physical memory using external page-cache management Authors: Kieran Harty View Profile , David R. Cheriton View Profile Authors Info & Claims ACM SIGPLAN NoticesVolume 27Issue 9Sept. 1992 pp 187–197https://doi.org/10.1145/143371.143511Published:01 September 1992Publication History 85citation1,024DownloadsMetricsTotal Citations85Total Downloads1,024Last 12 Months54Last 6 weeks15 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Role of nitric oxide in vasodilation in upstream muscle during intermittent pneumatic compression (2002)

This study investigated the dosage effects of nitric oxide synthase (NOS) inhibitor N(G)-monomethyl-L-arginine (L-NMMA) on intermittent pneumatic compression (IPC)-induced vasodilation in uncompressed upstream muscle and the effects of IPC on endothelial NOS (eNOS) expression in upstream muscle. After L-NMMA infusion, mean arterial pressure increased by 5% from baseline (99.5 +/- 18.7 mmHg; P < 0.05). Heart rate and respiratory rate were not significantly affected. One-hour IPC application on legs induced a 10% dilation from baseline in 10- to 20-microm arterioles and a 10-20% dilation in 21- to 40 microm arterioles and 41- to 70-microm arteries in uncompressed cremaster muscle. IPC-induced vasodilation was dose dependently reduced, abolished, or even reversed by concurrently infused L-NMMA. Moreover, expression of eNOS mRNA in uncompressed cremaster muscle was upregulated to 2 and 2.5 times normal at the end of 1- and 5-h IPC on legs, respectively, and the expression of eNOS protein was upregulated to 1.8 times normal. These increases returned to baseline level after cessation of IPC. The results suggest that eNOS plays an important role in regulating the microcirculation in upstream muscle during IPC.
Chimerization of mu-9 (1997)

The V-region sequence information will be used for design of humanized Mu-9, which will be evaluated for targeting gastrointestinal carcinomas.