gebhart/patrepeval huggingface dataset:
Networking for real-time control of integrated manufacturing processes (2003)

Results of experimentation at the network testbed which emulates the heterogeneous traffic in an integrated manufacturing system are reported. As the network traffic increases, the dynamic performance of the delayed control system which regulates the servomotor in the experimental facility degrades. The experimental device is representative of the drive mechanisms of machine tools which are affected by network-induced delays in a real-time manufacturing environment. The concept of transmitting real-time unacknowledged data and delayable acknowledged data packets is applicable to both manufacturing systems and to integrated voice and data communication networks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A discrete-time observer for flexible-joint manipulators (2003)

A robust observer-based control scheme is proposed for flexible joint robots. A robust observer, estimating the link acceleration and jerk from position and velocity measurements, is combined with a state feedback control law to achieve robust tracking. Both simulation and experimental results are presented to illustrate the techniques.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
61. Ascending Dose Trials of a Retroviral Replicating Vector (Toca 511) in Patients with Recurrent High-Grade Glioma: Clinical Update, Molecular Analyses, and Proposed Mechanism of Action (2016)

We have conducted Phase 1 studies in patients with high grade glioma of a retroviral replicating vector (RRV), Toca 511 (vocimagene amiretrorepvec), based on an amphotropic murine gamma retrovirus encoding an optimized cytosine deaminase. The vector appears highly selective for tumor cells. Infected cells convert the antifungal drug 5-fluorocytosine (5-FC) delivered as an orally available extended-release formulation (Toca FC), into the antineoplastic drug 5-fluorouracil (5-FU). Toca 511 has been delivered by intratumoral injection (NCT01156584), injection into the tumor bed post-resection (NCT01470794), or by IV administration (NCT01985256). In all cases the treatment is well-tolerated. In animal models extensive infection of tumors (close to 100%) leads to control of tumor growth both in xenograft and syngeneic models. Limited access to tumor tissue post Toca 511 treatment in trial subjects, and lack of good markers of human glioblastoma cells in these heterogeneous primary tumors make it difficult to determine the extent of cancer cell infection but there is good evidence of selective tumor infection by PCR, RTPCR and IHC against the CD protein. Clinical data in both the first two trials (intratumoral and resection bed administration with 39 and 43 evaluable subjects respectively) show a favorable safety profile and extended overall survival (OS) compared to historical controls. In the resection study, for example, median OS was 13.6 months compared to 7-8 months in matched historical controls, and the OS at 24 months was 32%. In addition an RNA expression signature in untreated resected tumors that predicts long term survival in trial subjects has been identified from subjects that subsequently underwent tumor bed administration of Toca 511 and Toca FC. This signature does not normally correlate with survival in available public data sets. In immune competent orthotopic animal models, Toca 511 and 5-FC treatment leads to apparent tumor elimination and induction of strong antitumor immune responses by several mechanisms, including local elimination of myeloid derived suppressor cells. Subcutaneous re-implantation of the same tumors did not lead to tumor growth in animals treated up to a year before, whereas tumors did develop in control naïve animals. Available data in the human trials are consistent with the immune response playing a significant role in the apparent clinical efficacy. Thus, clinically, treatment with Toca 511 and extended-release 5-FC (Toca FC) appears to selectively destroy tumor cells within the body, while leaving healthy cells unharmed. Toca 511 and Toca FC have been administered to more than 120 high grade glioma subjects in the three studies and, based on results from these trials, a phase 2/3 trial (Toca 5 has recently started recruitment (NCT02414165). The combination of clinical and preclinical data supporting this decision will be reviewed.
ChemInform Abstract: Oxidative S‐Dealkylation of tert‐Butyl Aryl Sulfides: A Novel Route to 3‐Substituted 3H‐1,2‐Benzodithioles. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Independent folding and conformational changes of the barnase module in the VL‐barnase immunofusion: calorimetric evidence (2003)

Although stability is critical for in vivo application of immunotoxins, a thermodynamic description of their folding/stability is still lacking. We applied differential scanning calorimetry (DSC) to RNase-based immunofusion comprising barnase, cytotoxic RNase from Bacillus amyloliquefaciens, fused to the light chain variable domain (VL) of anti-human ferritin antibody F11. By analyzing DSC curves recorded with or without preheating and addition of the barnase-stabilizing ligand guanosine 3'-monophosphate, we (i). assigned two well-resolved thermal transitions to the VL and barnase modules of VL-barnase, (ii). demonstrated independent folding of these two modules, and (iii). showed altered stability of the barnase module, which resulted from the dimeric state of VL-barnase.
Carbon Nanotube Scaffolds Instruct Human Dendritic Cells: Modulating Immune Responses by Contacts at the Nanoscale (2013)

Nanomaterials interact with cells and modify their function and biology. Manufacturing this ability can provide tissue-engineering scaffolds with nanostructures able to influence tissue growth and performance. Carbon nanotube compatibility with biomolecules motivated ongoing interest in the development of biosensors and devices including such materials. More recently, carbon nanotubes have been applied in several areas of nerve tissue engineering to study cell behavior or to instruct the growth and organization of neural networks. To gather further knowledge on the true potential of future constructs, in particular to assess their immune-modulatory action, we evaluate carbon nanotubes interactions with human dendritic cells (DCs). DCs are professional antigen-presenting cells and their behavior can predict immune responses triggered by adhesion-dependent signaling. Here, we incorporate DC cultures to carbon nanotubes and we show by phenotype, microscopy, and transcriptional analysis that in vitro differentiated and activated DCs show when interfaced to carbon nanotubes a lower immunogenic profile.
ChemInform Abstract: PREPARATION AND REACTIONS OF 1‐(PHENYLTHIO)‐2‐(TRIMETHYLSILYLOXY)‐1,3‐BUTADIENES. A ONE‐POT SYNTHESIS OF SULFUR‐SUBSTITUTED 7‐HYDROXYBICYCLO(2.2.1)HEPTANONES ‐ COUPLING OF THE DIELS‐ALDER REACTION WITH THE ALDOL PROCESS (1982)

Abstract Das neue Dien (IIa) reagiert mit Maleinsäureanhydrid bzw. N‐Phenyl‐maleinimid unter Bildung der Addukte (IV).
Dependency Networks for Collaborative Filtering and Data Visualization (2013)

We describe a graphical model for probabilistic relationships---an alternative to the Bayesian network---called a dependency network. The graph of a dependency network, unlike a Bayesian network, is potentially cyclic. The probability component of a dependency network, like a Bayesian network, is a set of conditional distributions, one for each node given its parents. We identify several basic properties of this representation and describe a computationally efficient procedure for learning the graph and probability components from data. We describe the application of this representation to probabilistic inference, collaborative filtering (the task of predicting preferences), and the visualization of acausal predictive relationships.
Receiver error concealment using acknowledge preview (RECAP) - An approach to resilient video streaming (2009)

High-quality and low-latency video streaming is essential to providing a natural user experience in video conferencing. This is challenging over lossy networks since compressed video is highly fragile while the low-latency requirement limits the effectiveness of traditional error control approaches such as retransmission and forward error correction. In this paper, we advocate a practical solution for low-latency video communications over best-effort networks that employs an additional low-quality, low-resolution but robustly coded copy of the video. This approach, called RECAP, incurs minimal rate overhead, and can be combined with previously decoded frames to achieve effective concealment of isolated and burst losses even under tight delay constraints. RECAP achieves PSNR gains of 2-6 dB against complete frame loss.
P312 Efficacy in biologic failure and non-biologic-failure populations in a Phase 3 study of ustekinumab in moderate–severe ulcerative colitis: UNIFI (2019)

Ustekinumab (UST), an IL12/23 blocker approved for Crohn’s disease, was effective in Ph3 induction and maintenance of moderate–severe ulcerative colitis (UC). Efficacy in biologic-failure (BF) and non-biologic-failure (NBF) populations was evaluated. Pts were randomised to a baseline IV induction UST dose (130 mg or weight-range based doses approximating 6 mg/kg (~6 mg/kg)), or PBO. Responders to UST IV induction entered maintenance and were randomised to SC 90 mg UST (q12wks or q8wks), or PBO. Primary endpoint for wk8 induction and wk44 maintenance was clinical remission. Major secondary endpoints for wk8 induction: endoscopic healing, clinical response, and change from baseline in total IBDQ score and wk44 maintenance: maintenance of clinical response, endoscopic healing, corticosteroid-free clinical remission, and maintenance of clinical remission in baseline remitters. Among patients with documented BF (51.1% of randomised patients), 98.8% had failed at least 1 anti-TNF, 32.6% had failed both anti-TNF and vedolizumab. NBF patients were predominantly bio-naïve (94.3%). In induction, for BF and NBF patients, proportions of patients who achieved clinical remission was significantly greater for UST ~6 mg/kg and 130 mg vs. PBO (BF patients-p < 0.001 for both doses; NBF patients-p < 0.05 for both doses, respectively, Table 1). For BF and NBF patients, major secondary endpoints of clinical response and endoscopic healing and change from baseline in IBDQ were significantly greater for UST ~6 mg/kg and 130 mg vs. PBO (Table 1). Though treatment differences were generally similar between BF and NBF patients, rates were consistently lower for BF patients in each treatment group. In maintenance, for BF and NBF patients, proportions of patients who achieved clinical remission was significantly greater for UST q8w and q12w vs. PBO (BF patients-p < 0.001, p = 0.044, respectively; NBF patients-p = 0.024, p = 0.020, respectively, Table 2). For BF and NBF patients, proportions of patients who achieved each major secondary endpoint was generally greater for UST q8wk and q12wk vs. PBO. In BF patients, the efficacy of UST q8wk was generally greater than UST q12wk (Table 2). UST was effective for induction and maintenance treatment of moderate–severe UC patients with a history of biologic therapy failure (ie, TNF-antagonists and/or vedolizumab) as well as patients without a history of biologic therapy failure who were predominantly bio-naive. Table 1. UNIFI Induction key endpoints at Week 8 by biologic failure vs. non-biologic failure. Table 2. UNIFI Maintenance key endpoints at Week 44 by biologic failure vs. non-biologic failure.
Molecular Dissection of Telomeric Repeat-Containing RNA Biogenesis Unveils the Presence of Distinct and Multiple Regulatory Pathways (2010)

Telomeres are transcribed into telomeric repeat-containing RNA (TERRA), large, heterogeneous, noncoding transcripts which form part of the telomeric heterochromatin. Despite a large number of functions that have been ascribed to TERRA, little is known about its biogenesis. Here, we present the first comprehensive analysis of the molecular structure of TERRA. We identify biochemically distinct TERRA complexes, and we describe TERRA regulation during the cell cycle. Moreover, we demonstrate that TERRA 5' ends contain 7-methylguanosine cap structures and that the poly(A) tail, present on a fraction of TERRA transcripts, contributes to their stability. Poly(A)(-) TERRA, but not poly(A)(+) TERRA, is associated with chromatin, possibly reflecting distinct biological roles of TERRA ribonucleoprotein complexes. In support of this idea, poly(A)(-) and poly(A)(+) TERRA molecules end with distinct sequence registers. We also determine that the bulk of 3'-terminal UUAGGG repeats have an average length of 200 bases, indicating that the length heterogeneity of TERRA likely stems from its subtelomeric regions. Finally, we find that TERRA is regulated during the cell cycle, being lowest in late S phase and peaking in early G(1). Our analyses offer the basis for investigating multiple regulatory pathways that affect TERRA synthesis, processing, turnover, and function.
Disruption of the Complement Anaphylatoxin Receptor C5L2 Exacerbates Inflammation in Allergic Contact Dermatitis (2013)

The complement anaphylatoxin C5a is a critical mediator of allergic contact dermatitis, bridging essential aspects of innate and adaptive immunity. This anaphylatoxin functions by interacting with two 7-transmembrane segment receptors, the C5aR and C5L2. The C5aR is a classical G protein coupled receptor, whereas C5L2 is deficient in coupling to G proteins because of variations in the sequence. Our previous work in human neutrophils revealed a unique role for C5L2 in negatively modulating anaphylatoxin receptor mediated cellular activation through interactions with β-arrestin. When C5L2 is deficient, C5aR-mediated β-arrestin signaling is greatly enhanced. The work described in this study was undertaken first to determine the effect of C5L2 deficiency in a murine model of contact sensitivity, and second to determine whether the resultant exacerbation of inflammatory parameters reflects a negative modulatory function of C5L2 on the C5aR. First, we find dramatic increases in inflammation in C5L2(-/-) animals compared with wild type mice. Second, these increases are completely reversed following administration of mAb against the C5aR. Thus, in allergic contact sensitivity, as in isolated human neutrophils, C5L2 functions to suppress C5a-C5aR-mediated responses, further underscoring its role as a negative regulator of anaphylatoxin activity.
From local to global coherence: a bottom-up approach to text planning (1997)

We present a new, data-driven approach to text planning, which can be used not only to map full knowledge pools into natural language texts, but also to generate texts that satisfy multiple, high-level communicative goals. The approach explains how global coherence can be achieved by exploiting the local coherence constraints of rhetorical relations. The local constraints were derived from a corpus analysis. Motivation 1 All current flexible approaches to text planning that assume that the abstract structure of text is a tree-like structure are, esentially, top-down approaches. Some of them define plan operators and exploit hierarchical planning techniques (Hovy 1993; Moore and Paris 1993; Moore and Swartout 1991; Cawsey 1991; Maybury 1992) and partial-order planning techniques (Young and Moore 1994). Others assume that plans are hierarchically organized sets of frames that can be derived through a top-down expansion process (Nirenburg et al. 1989; Meteer 1992). And the recursive app...
Kinematics of Clustering (2014)

The dynamical system for inertial particles in fluid flow has both attracting and repelling regions, the interplay of which can localize particles. In laminar flow experiments we find that particles, initially moving throughout the fluid domain, can undergo an instability and cluster into subdomains of the fluid when the flow Reynolds number exceeds a critical value that depends on particle and fluid inertia. We derive an expression for the instability boundary and for a universal curve that describes the clustering rate for all particles.
Biomechanical Comparison of Stainless Steel and Titanium Nails for Fixation of Simulated Femoral Fractures (2004)

Flexible intramedullary nails are commonly used to treat femoral fractures in children. This study evaluated the biomechanical differences between stainless steel and titanium nails when securing transverse and comminuted fractures in a synthetic femur model. Retrograde flexible stainless steel and titanium nails placed in a divergent "C" pattern were mechanically tested, and axial rotation and compression stiffness were analyzed with a two-way ANOVA. Rotational stability was significantly greater for titanium nails than stainless steel nails for both fracture patterns. Axial compression stiffness was significantly greater for titanium nails than stainless steel nails for both fracture patterns. There was no statistical difference between materials for axial "failure" load that produced 5 mm of shortening. Titanium intramedullary nails were more stable than stainless steel nails in torsion and axial compression. Both materials stabilized simulated fractures at levels beyond physiologic non-weight-bearing loads without permanent deformation.
Infrastructure Bandwidth Allocation for Social Welfare Maximization in Future Connected Autonomous Vehicular Networks (2017)

Control of conventional transportation networks aims at bringing the state of the network to the system optimal (SO) state. This optimum is characterized by the minimality of the social cost function, i.e., the total cost of travel of all drivers. On the other hand, drivers are assumed to be rational and selfish, and make their travel decisions to optimize their own travel costs, bringing the state of the network to a user equilibrium (UE). In this paper, we model the behavior of users in the future connected vehicular transportation networks, where users consider both the travel cost and the utility from data communication when making their travel decisions. We divide the users into two groups based on the kind of data network they are using. We leverage the data communication aspect of the decision making to influence the user route choices, driving the UE state to the SO state. We propose a V2I bandwidth allocation scheme, which provides a guideline on how the system operator can adjust the parameters of the communication network to achieve the optimal UE.
Die-attach Properties of Pressure-sintered Copper Joints on Adhesive Metallization Surfaces in N2 Atmosphere (2021)

Die-attach properties of mechanical pressure-assisted sintered copper (pressure-sintered Cu) on some metallization layers in N2 atmosphere for high-power devices were investigated. The shear strength of pressure-sintered Cu on Ag plating increased as the bonding temperatures and bonding pressures increased. On the bonding conditions (2 MPa, 300 °C, 3 min and 60 min), the shear strength of pressure-sintered Cu on Ni and Ag plating increased with increasing bonding time, whereas that of pressure-sintered Cu on Au plating decreased. The decrease of shear strength on the Au plating was seemingly attributed to the marked interdiffusion of the interface between sintered Cu and Au plating.
ChemInform Abstract: Prussian Blue: A New Framework of Electrode Materials for Sodium Batteries. (2012)

Abstract KMFe(CN) 6 (M: Mn, Fe, Co, Nu, Zn) Prussian blue analogues are synthesized at room temperature by addition of M(II) salt solutions to K 3 Fe(CN) 6 solution (ultrasound, stirring, 2 h).
High-power GaN MMIC PA Over 40&#x2013;4000MHz (2013)

We report a high-performance GaN MMIC power amplifier operating from 40MHz to 4,000MHz. The MMIC achieved 80W pulsed (100us pulse width and 10% duty cycle) output power (P5dB) with 54% efficiency at 40MHz, 50W with about 30% efficiency across most of the mid band, and gradually decreases to 30W with 22% efficiency at 4000MHz. Power gain is 25dB across the 40–4000MHz band. This ultra wideband performance is achieved by both tailoring the device output impedance, and using a unique wide-band, circuit-matching topology. Detailed design techniques of both the device and the matching circuit will be presented.
Experimental characterization of interference in OFDMA femtocell networks (2012)

The increase in mobile data usage is pushing broadband operators towards deploying smaller cells (femtocells) and sophisticated access technologies such as OFDMA. The expected high density of deployment and uncoordinated operations of femtocells however, make interference management both critical and extremely challenging. Femtocells have to use the same access technology as traditional macrocells. Given this, understanding the impact of the system design choices (originally tailored to well-planned macrocells) on interference management, forms an essential first step towards designing efficient solutions for next-generation femtocells. This in turn is the focus of our work. With extensive measurements from our WiMAX OFDMA femtocell testbed, we characterize the impact of various system design choices on interference. Based on the insights from our measurements, we discuss several implications on how to efficiently operate a femtocell network.
Pathway-Specific Analysis of Gene Expression Data Identifies the PI3K/Akt Pathway as a Novel Therapeutic Target in Cervical Cancer (2012)

Activation of the PI3K/Akt pathway is associated with incomplete metabolic response in cervical cancer. Targeted inhibition of PI3K/Akt may improve response to chemoradiation.
VXI evaluation testbed (2002)

The scope of this work includes a system description of the VXI testbed and its intended usage and a description of problems, concerns, and recommendations to date. A description is also given of the approach being taken to get on line with VXI as quickly as possible. It is shown that the VXI testbed is proving to be a very useful tool. Not only does it provide a vehicle for training personnel in the use of VXI technology, but it provides a real means to evaluate and exercise hardware and software.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Graphene RF Transistor Performance (2010)

Recent excitement about graphene as a possible material for high-frequency electronics has lead to demonstrations of high-frequency field-effect transistors (FETs) in the last two years. Although graphene FETs operate by a different principle than silicon MOSFETs, and have different dc characteristics, their ac properties are quite similar. Hence the high intrinsic mobility of graphene leads to the expectation of high frequency operation of gated graphene FETs. Demonstrations of frequency response in the GHz regime have been shown using both exfoliated flakes and synthesized graphene. An intrinsic cut-off frequency as high as 100 GHz has been achieved in a 240-nm-gate graphene FET fabricated on a 2" wafer of epitaxially-grown graphene. This value exceeds that of Si MOSFETs at the same gate length, illustrating the potential of graphene for RF applications.