gebhart/patrepeval huggingface dataset:
QoT function and A^* routing: an optimized combination for connection search in translucent networks (2008)

&lt;p&gt;&lt;a href="http://www.osa-jon.org/virtual_issue.cfm?vid=31"&gt;Feature Issue on Transmission in Optically Transparent Core Networks&lt;/a&gt;&lt;/p&gt;We investigate a new routing algorithm able to finely consider signal quality during propagation in an optical WDM meshed network. To evaluate the quality of transmission, we propose an analytical estimator based on experimental measurements, along with an assessment of its accuracy. The proposed algorithm 'places' optoelectronic (OEO) regenerators, taking into account the wavelength occupation and the quality of transmission of the selected optical path, so it can optimize the number of required OEO operations for a connection. To validate the interest of the proposed algorithm and the quality of transmission estimator, we present dimensioning results for two different routing strategies and two different estimators of transmission quality. The performance of the proposed methods is particularly relevant compared to works in present literature where system characteristics are not ideal.
An Innovative Modelling Approach in Characterization of Autonomous Inflow Control Valve Performance to Maximizing Oil Recovery in Heavy Oil-SAGD Application (2021)

Abstract Flow control devices (FCDs) have demonstrated significant potential in improving recovery from Steam Assisted Gravity Drainage (SAGD) production wells. Passive FCDs will allow the SAGD producer well to create additional pressure drop to balance the production influx, improving overall conformance and promoting accelerated hydrocarbon production. However, passive FCDs cannot effectively restrict steam effluents once steam breakthrough at the production well occurs. The Autonomous Inflow Control Valve (AICV) actively delivers a dynamic flow restriction with the ability to choke and/or ‘shut-off’ in response to the associated viscosity and density of the fluids flowing through the AICV. This novel AICV design behaves truly autonomously based on the Hagen-Poiseuille equation and Bernoulli’s principle. The AICV utilizes the differences in flow behaviour between the laminar and turbulent flow restrictions to differentiate the pressure-drops between oil, water, gas, and steam phases. A collaborative effort has been initiated between the AICV vendor and the Computer Modelling Group to develop reservoir simulation workflows with the AICV that will allow the user to enter characteristic performance curves for a variety of SAGD and thermal fields. The development of mechanistic wellbore modelling and developed methodology to incorporate the associated complexities of AICV behaviour has shown to be an improvement to the way FCDs are currently modelled, providing insight into the potential for AICV application in SAGD and other thermal recovery operations. Such techniques allow the reservoir simulation tools to perform realistic predictions of the AICV behaviour at downhole conditions and evaluate scenarios and relative impacts of completion designs. The development of a new characterization method of AICV performance in SAGD applications, and its implementation in reservoir simulation tools, has helped to unveil the benefits of implementing AICVs in improving recovery from SAGD operations.
29Si imaging of silicone breast implants and intraocular silicone oil (1998)

Silicon-29 (29Si) imaging was investigated as a potential imaging modality for monitoring silicone prostheses in humans. The 29Si relaxation times of several silicone gels were measured and found to average T1 = 21.2 +/- 1.5 s and T2 = 207 +/- 40 ms, with no significant difference between virgin and explanted gels. A single-shot half-Fourier rapid acquisition with relaxation enhancement (RARE) and a refocused gradient-echo sequence were used for acquiring 29Si images with 5 x 5 mm2 resolution and no slice selection. Three volunteers with silicone-gel-filled breast implants and one subject with an intraocular silicone oil injection were thus examined in a total acquisition time of 10-15 min per image. On all 29Si images, the shape of the silicone object was well depicted. Although at present, conventional proton images are superior in resolution and signal-to-noise ratio, 29Si imaging has the advantage of optimal specificity, since only the silicone itself is visible.
Total synthesis of the highly oxygenated quassinoid (.+-.)-klaineanone (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of the highly oxygenated quassinoid (.+-.)-klaineanonePaul A. Grieco, Ravi P. Nargund, and David T. ParkerCite this: J. Am. Chem. Soc. 1989, 111, 16, 6287–6294Publication Date (Print):August 1, 1989Publication History Published online1 May 2002Published inissue 1 August 1989https://pubs.acs.org/doi/10.1021/ja00198a046https://doi.org/10.1021/ja00198a046research-articleACS PublicationsRequest reuse permissionsArticle Views774Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Influence of crosslinker identity and position on gas-phase dissociation of lys-lys crosslinked peptides (2006)

A systematic study of the dissociation patterns of crosslinked peptides analyzed by tandem mass spectrometry is reported. A series of 11-mer peptides was designed around either a polyalanine or polyglycine scaffold with arginine at the C terminus. One or two lysine residues were included at various locations within the peptides to effect inter- or intra-molecular crosslinking, respectively. Crosslinked species were generated with four commonly used amine-specific chemical crosslinking reagents: disuccinimidyl suberate (DSS), disuccinimidyl tartarate (DST), dithiobis(succinimidylpropionate) (DSP), and disuccinimidyl glutarate (DSG). The influence of precursor charge state, location of crosslink, and specific crosslinking reagent on the MS/MS dissociation pattern was examined. Observed trends in the dissociation patterns obtained for these species will allow for improvements to software used in the automated interpretation of crosslinked peptide MS/MS data.
Peptide-specific T helper cells identified by MHC class II tetramers differentiate into several subtypes upon immunization with CAF01 adjuvanted H56 tuberculosis vaccine formulation (2015)

CD4(+) T-cell priming is an essential step in vaccination due to the key role of T helper cells in driving both effector and memory immune responses. Here we have characterized in C57BL/6 mice the T helper subtype differentiation among tetramer-specific CD4(+) T cells primed by subcutaneous immunization with the tuberculosis vaccine antigen H56 plus the adjuvant CAF01. Peptide-specific population identified by the MHC class II tetramers differentiated into several T helper subtypes upon antigen encounter, and the frequency of subpopulations differed according to their localization. Th1 (CXCR3(+)T-bet(+)), Tfh (CXCR5(+)PD-1(+)Bcl-6(+)) and RORγt(+) cells were induced in the lymph nodes draining the immunization site (dLN), while Th1 cells were the predominant subtype in the spleen. In addition, CD4(+) T cells co-expressing multiple T-cell lineage-specifying transcription factors were also detected. In the lungs, most of the tetramer-binding T cells were RORγt(+), while Tfh and Th1 cells were absent. After boosting, a higher frequency of tetramer-binding cells co-expressing the markers CD44 and CD127 was detected compared to primed cells, and cells showed a prevalent Th1 phenotype in both dLN and spleens, while Tfh cells were significantly reduced. In conclusion, these data demonstrate that parenteral immunization with H56 and CAF01 elicits a distribution of antigen-specific CD4(+) T cells in both lymphoid tissues and lungs, and gives rise to multiple T helper subtypes, that differ depending on localization and following reactivation.
Immune response proteins as predictive biomarkers of doxorubicin-induced cardiotoxicity in breast cancer patients (2017)

Cancer treatment with doxorubicin (DOX) can induce cumulative dose-dependent cardiotoxicity. Currently, there are no specific biomarkers that can identify patients at risk during the initial doses of chemotherapy. The aim of this study was to examine plasma cytokines/chemokines and potential cardiovascular biomarkers for the prediction of DOX-induced cardiotoxicity. Plasma samples were collected before (T0), and after the first (T1) and the second (T2) cycles of DOX-based chemotherapy of 27 breast cancer patients, including five patients who presented with >10% decline of left ventricular ejection fraction (LVEF), five patients with LVEF decline of 5-10%, and 17 patients who maintained normal LVEF at the end of chemotherapy (240 mg/m<sup>2</sup> cumulative dose of DOX from four cycles of treatment). Multiplex immunoassays were used to screen plasma samples for 40 distinct chemokines, nine matrix metalloproteinases, 33 potential markers of cardiovascular diseases, and the fourth-generation cardiac troponin T assay. The results showed that the patients with abnormal decline of LVEF (>10%) had lower levels of CXCL6 and sICAM-1 and higher levels of CCL23 and CCL27 at T0; higher levels of CCL23 and lower levels of CXCL5, CCL26, CXCL6, GM-CSF, CXCL1, IFN-γ, IL-2, IL-8, CXCL11, CXCL9, CCL17, and CCL25 at T1; and higher levels of MIF and CCL23 at T2 than the patients who maintained normal LVEF. Patients with LVEF decline of 5-10% had lower plasma levels of CXCL1, CCL3, GDF-15, and haptoglobin at T0; lower levels of IL-16, FABP3, and myoglobin at T1; and lower levels of myoglobin and CCL23 at T2 as compared to the patients who maintained normal LVEF. This pilot study identified potential biomarkers that may help predict which patients are vulnerable to DOX-induced cardiotoxicity although further validation is needed in a larger cohort of patients. Impact statement Drug-induced cardiotoxicity is one of the major concerns in drug development and clinical practice. It is critical to detect potential cardiotoxicity early before onset of symptomatic cardiac dysfunction or heart failure. Currently there are no qualified clinical biomarkers for the prediction of cardiotoxicity caused by cancer treatment such as doxorubicin (DOX). By using multiplex immunoassays, we identified proteins with significantly changed plasma levels in a group of breast cancer patients who were treated with DOX-based chemotherapy and produced cardiotoxicity. These proteins were associated with immune response and were identified before DOX treatment or at early doses of treatment, thus they could be potential predictive biomarkers of cardiotoxicity although further validation is required to warrant their clinical values.
Learning in Distributed Contextual Linear Bandits Without Sharing the Context (2022)

Contextual linear bandits is a rich and theoretically important model that has many practical applications. Recently, this setup gained a lot of interest in applications over wireless where communication constraints can be a performance bottleneck, especially when the contexts come from a large $d$-dimensional space. In this paper, we consider a distributed memoryless contextual linear bandit learning problem, where the agents who observe the contexts and take actions are geographically separated from the learner who performs the learning while not seeing the contexts. We assume that contexts are generated from a distribution and propose a method that uses $\approx 5d$ bits per context for the case of unknown context distribution and $0$ bits per context if the context distribution is known, while achieving nearly the same regret bound as if the contexts were directly observable. The former bound improves upon existing bounds by a $\log(T)$ factor, where $T$ is the length of the horizon, while the latter achieves information theoretical tightness.
Optical mouse sensors for tracking surgical instruments (2007)

The computer mouse is a popular pointing device used to control the position of a cursor on a computer display. Sensors used in optical mice enable the contactless measuring of the changes in position over a flat surface.This article describes the application of optical mouse sensors as position sensors in a tracking system ‐ TrEndo ‐ that has been developed at Delft University of Technology and the Academic Medical Centre Amsterdam.
Binary copper carbonyls. Synthesis and characterization of tricarbonylcopper, dicarbonylcopper, monocarbonylcopper, and hexacarbonyldicopper (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBinary copper carbonyls. Synthesis and characterization of tricarbonylcopper, dicarbonylcopper, monocarbonylcopper, and hexacarbonyldicopperH. Huber, E. P. Kuendig, M. Moskovits, and G. A. OzinCite this: J. Am. Chem. Soc. 1975, 97, 8, 2097–2106Publication Date (Print):April 1, 1975Publication History Published online1 May 2002Published inissue 1 April 1975https://pubs.acs.org/doi/10.1021/ja00841a017https://doi.org/10.1021/ja00841a017research-articleACS PublicationsRequest reuse permissionsArticle Views500Altmetric-Citations114LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Online δ13C analysis of volatile fatty acids in sediment/porewater systems by liquid chromatography-isotope ratio mass spectrometry (2006)

Volatile fatty acids (VFAs) are central intermediates of anaerobic metabolism and present in aquatic environments such as marine sediments. Conceptually, the isotopic composition of volatile fatty acids is presumed to be sensitive to the specific biogeochemical processes involved in their production and consumption. However, due to generally low environmental concentrations, our knowledge on isotopic variability of VFAs is limited. We report the development and application of a new protocol for compound-specific carbon isotopic analysis of VFAs in marine porewaters and other aqueous liquids. This new protocol involves reversed-phase separation of volatile fatty acids with an aqueous mobile phase by high performance liquid chromatography (HPLC) combined with chemical oxidation of the effluents by the FinniganTM LC IsoLink interface (Krummen et al. 2004) and subsequent online transfer of the resulting CO2 into an isotope ratio mass spectrometer. We obtained reproducible and accurate results for pure Na-acetate dissolved in artificial seawater at concentrations as low as 2 µM, whereas minimum concentrations in marine porewaters were 10 µM. Our technique extends the previously accessible concentration range and the fully automated online operation allows for systematic analysis of large sample sets. These technical improvements make carbon isotopic analysis of selected VFAs a realistic perspective for many sedimentary environments. Our initial survey of acetate in porewaters and fluids obtained from incubations of marine sediments has revealed an unexpectedly large range of isotopic compositions from −5‰ to −85‰ and provides strong support for process-specific information encoded in the isotopic compositions of VFAs.
Radical Reactions with Alkyl and Fluoroalkyl (Fluorous) Tin Hydride Reagents in Supercritical CO2 (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTRadical Reactions with Alkyl and Fluoroalkyl (Fluorous) Tin Hydride Reagents in Supercritical CO2Sabine Hadida, Michael S. Super, Eric J. Beckman, and Dennis P. CurranView Author Information Department of Chemistry, University of Pittsburgh Pittsburgh, Pennsylvania 15260 Department of Chemical Engineering, University of Pittsburgh Pittsburgh, Pennsylvania 15261 Cite this: J. Am. Chem. Soc. 1997, 119, 31, 7406–7407Publication Date (Web):August 6, 1997Publication History Received8 April 1997Published online6 August 1997Published inissue 1 August 1997https://pubs.acs.org/doi/10.1021/ja971120ihttps://doi.org/10.1021/ja971120irapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views734Altmetric-Citations79LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Anions,Chemical reactions,Organic reactions,Reagents,Solvents Get e-Alerts
CD5+ B cells from individuals with systemic lupus erythematosus express granzyme B (2010)

Recently, we reported that IL-21 induces granzyme B (GzmB) and GzmB-dependent apoptosis in malignant CD5(+) B cells from patients with chronic lymphocytic leukemia. Several autoimmune diseases (AD) are associated with enhanced frequencies of CD5(+) B cells. Since AD are also associated with elevated IL-21 and GzmB levels, we postulated a link between CD5(+) B cells, IL-21 and GzmB. Here, we demonstrate that IL-21 and GzmB serum levels are highly correlated in subjects with systemic lupus erythematosus (SLE) and that freshly isolated CD5(+) SLE B cells constitutively express GzmB. IL-21 directly induced GzmB expression and secretion by CD5(+) B cells from several AD and from cord blood in vitro, and the simultaneous presence of BCR stimulation strongly enhanced this process. Furthermore, IL-21 suppressed both viability and expansion of CD5(+) B cells from SLE individuals. In summary, our study may explain the elevated levels of IL-21 and GzmB in SLE and other AD. Moreover, our data suggest that IL-21 may have disease-modifying characteristics by inducing GzmB in CD5(+) B cells and by suppressing their expansion. Our results provide the rationale for further evaluation of the therapeutic potential of IL-21 in certain AD such as SLE.
Accelerated microdroplet synthesis of benzimidazoles by nucleophilic addition to protonated carboxylic acids (2020)

We report a metal-free novel route for the accelerated synthesis of benzimidazole and its derivatives in the ambient atmosphere. The synthetic procedure involves 1,2-aromatic diamines and alkyl or aryl carboxylic acids reacting in electrostatically charged microdroplets generated using a nano-electrospray (nESI) ion source. The reactions are accelerated by orders of magnitude in comparison to the bulk. No other acid, base or catalyst is used. Online analysis of the microdroplet accelerated reaction products is performed by mass spectrometry. We provide evidence for an acid catalyzed reaction mechanism based on identification of the intermediate arylamides. Their dehydration to give benzimidazoles occurs in a subsequent thermally enhanced step. It is suggested that the extraordinary acidity at the droplet surface allows the carboxylic acid to function as a C-centered electrophile. Comparisons of this methodology with data from thin film and bulk synthesis lead to the proposal of three key steps in the reaction: (i) formation of an unusual reagent (protonated carboxylic acid) because of the extraordinary conditions at the droplet interface, (ii) accelerated bimolecular reaction because of limited solvation at the interface and (iii) thermally assisted elimination of water. Eleven examples are shown as evidence of the scope of this chemistry. The accelerated synthesis has been scaled-up to establish the substituent-dependence and to isolate products for NMR characterization.
ChemInform Abstract: Asymmetric Synthesis of Topographically Constrained Amino Acids: Synthesis of the Optically Pure Isomers of Dimethyl‐α,β‐ phenylalanine and α,β‐Dimethyl‐1,2,3,4‐ tetrahydroisoquinoline 3‐Carboxylic Acid. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.