gebhart/patrepeval huggingface dataset:
pRB-Dependent, J Domain-Independent Function of Simian Virus 40 Large T Antigen in Override of p53 Growth Suppression (2000)

Simian virus 40 (SV40) large T antigen (LT) can immortalize and transform many cell types. These activities are attributed in large part to the binding and functional inactivation by LT of two major tumor suppressors: p53 and the retinoblastoma protein, pRB. Most effects of LT on pRB have been shown to additionally require an intact J domain, which mediates binding to Hsc70. We show here that the J domain is not required for p53 override in full-length LT. Although LT binds p53, it was shown previously that overcoming a p53-induced cell cycle arrest requires binding to pRB family members (R. S. Quartin et al., J. Virol. 68:1334-1341). We demonstrate that an LT mutant defective for pRB family member binding (K1) can be complemented for efficient override of p53 arrest by a construct encoding the first 135 amino acids of LT with a J domain-inactivating mutation, H42Q. Hence, complementation does not require the J domain, and pRB binding by LT is important for more than dissociating pRB-E2F complexes, which is J dependent. In accordance with this notion, LT alleviates pRB small-pocket-mediated transcriptional repression independently of the J domain. The LT K1 mutant can also be complemented for p53 override by small t antigen (st) in a manner independent of its J domain. Our observations underscore the importance of multiple SV40 functions, two in LT and one in st, that act cooperatively to counteract p53 growth suppression.
Reply: Muscle Fascia Changes in Patients with Occipital Neuralgia, Headache, or Migraine (2021)

We thank the authors for their interest in this article.1 First, for this study, we did not obtain ultrasound measurements to correlate these measurements with our intraoperative findings. However, we did subsequently obtain preoperative diagnostic ultrasound imaging on patients with occipital migraine/headache/neuralgia and compared fascial thickness in these patients to that of matched healthy control patients. We presented these preliminary data at Plastic Surgery The Meeting 2020, the 89th Annual Meeting of the American Society of Plastic Surgeons, and found that the trapezius fascia is significantly thicker in patients presenting with occipital migraine/headache as compared with control subjects.2 We agree that it would be interesting to correlate trapezius fascia thickness measured on ultrasound to trapezius fascia thickness intraoperatively, which we are currently doing. Second, in terms of site of nerve decompression, all patients were operated on at the greater occipital nerve trigger site. For this study, we decompressed the occipital nerve at all the six sites described by Janis et al.3 Lastly, we would like to comment in regard to their question concerning the 10 percent of patients who showed no postdecompression improvement (0 percent Migraine Headache Index improvement). Given the small number of patients who completely failed decompression, we are unable to draw statistically significant conclusions and therefore did not include these findings in the article. We thank the authors again for their interesting comments. DISCLOSURE Neither author has a financial interest to declare in relation to the content of this communication. Lisa Gfrerer, M.D., Ph.D.William G. Austen, Jr., M.D.Division of Plastic and Reconstructive SurgeryMassachusetts General HospitalHarvard Medical SchoolBoston, Mass.
High gradient silicon carbide immersion lens ultrafast electron sources (2022)

We present two compact ultrafast electron injector designs with integrated focusing that provide high peak brightness of up to 1.9 × 1012 A/m2 Sr2 with 10’s of electrons per laser pulse using silicon carbide electrodes and silicon nanotip emitters. We demonstrate a few centimeter scale 96 keV immersion lens electron source and a 57 keV immersion lens electron source with a 19 kV/mm average acceleration gradient, nearly double the typical 10 kV/mm used in DC electron sources. The brightness of the electron sources is measured alongside start-to-end simulations including space charge effects. These sources are suitable for dielectric laser accelerator experiments, ultrafast electron diffraction, and other applications, where a compact high brightness electron source is required.
SpaRibs Geometry Parameterization for Wings with Multiple Sections using Single Design Space (2017)

The SpaRibs topology of an aircraft wing has a significant effect on its structural behavior and stability as well as the flutter performance. The development of additive manufacturing techniques like Electron Beam Free Form Fabrication (EBF3) has made it feasible to manufacture aircraft wings with curvilinear spars, ribs (SpaRibs) and stiffeners. In this article a new global-local optimization framework for wing with multiple sections using curvilinear SpaRibs is described. A single design space is used to parameterize the SpaRibs geometry. This method has been implemented using MSC-PATRAN to create a broad range of SpaRibs topologies using limited number of parameters. It ensures C0 and C1 continuities in SpaRibs geometry at the junction of two wing sections with airfoil thickness gradient discontinuity as well as mesh continuity between all structural components. This method is advantageous in complex multi-disciplinary optimization due to its potential to reduce the number of design variables. For the global-local optimization the local panels are generated by an algorithm which is totally based on a set algebra on the connectivity matrix data. The great advantage of this method is that it is completely independent of the coordinates of the nodes of the finite element model. It is also independent of the order in which the elements are distributed in the FEM. The code is verified by optimizing of the CRM Baseline model at trim condition at Mach number equal to 0.85 for five different angle of attack (-2deg, 0deg,2deg,4deg and 6deg). The final weight of the wing is 19,090.61 lb. This value is comparable to that obtained by Qiang et al. 6 (19,269 lb).
A laser-locked cavity ring-down spectrometer employing an analog detection scheme (2000)

A system is described that employs a diode-pumped Nd:YAG continuous-wave laser source servolocked to a three-mirror optical cavity and an analog detection circuit that extracts the ring-down rate from the exponentially decaying ring-down waveform. This scheme improves on traditional cavity ring-down spectroscopy setups by increasing signal acquisition rates to tens of kilohertz and reducing measurement noise sources. For example, an absorption spectrum of a weak CO2 transition at 1064 nm is obtained in less than 10 s at a spectral resolution of 75 kHz employing a cavity with an empty-cavity ring-down decay lifetime of 2.8 μs and a total roundtrip path length of 42 cm. The analog detection system enables laser frequency scan rates greater than 500 MHz/s. The long-term sensitivity of this system is 8.8×10−12 cm−1 Hz−1/2 and the short-term sensitivity is 1.0×10−12 cm−1 Hz−1/2.
Final Report: High Energy Physics Program (HEP), Physics Department, Princeton University (2013)

The activities of the Princeton Elementary particles group funded through Department of Energy Grant# DEFG02-91 ER40671 during the period October 1, 1991 through January 31, 2013 are summarized. These activities include experiments performed at Brookhaven National Lab; the CERN Lab in Geneva, Switzerland; Fermilab; KEK in Tsukuba City, Japan; the Stanford Linear Accelerator Center; as well as extensive experimental and the- oretical studies conducted on the campus of Princeton University. Funded senior personnel include: Curtis Callan, Stephen Gubser, Valerie Halyo, Daniel Marlow, Kirk McDonald, Pe- ter Meyers, James Olsen, Pierre Pirou e, Eric Prebys, A.J. Stewart Smith, Frank Shoemaker (deceased), Paul Steinhardt, David Stickland, Christopher Tully, and Liantao Wang.
Expanded viewing-angle reflection from diffuse holographic-polymer dispersed liquid crystal films (2000)

A switchable diffuse reflective film with high color purity is demonstrated using holographic-polymer dispersed liquid crystals (HPDLC). By recording a diffuse hologram directly into the LC/polymer film, the diffuse mode HPDLC exhibit viewing angles an order of magnitude larger than the conventional mode. A simple phenomenological model based on coupled-wave theory is developed to describe our observations.
Dynamic Quantized Fracture Mechanics (2005)

A new quantum action-based theory, Dynamic Quantized Fracture Mechanics (DQFM), is presented that modifies continuum-based dynamic fracture mechanics. The crack propagation is assumed as quantized in both space and time. The static limit case corresponds to Quantized Fracture Mechanics (QFM), that we have recently developed to predict the strength of nanostructures.
Role of endotoxin in intestinal reperfusion-induced expression of E-selectin (1999)

Products of enteric bacteria, including endotoxin [lipopolysaccharide (LPS)], have been implicated in the acute inflammatory responses elicited by ischemia and reperfusion (I/R) of the small intestine. The objective of this study was to assess the contribution of LPS to the increased E-selectin expression observed in the intestinal vasculature after I/R. The dual radiolabeled monoclonal antibody technique was used in LPS-sensitive (C3HeB/FeJ) and LPS-insensitive (C3H/HeJ) mice that were exposed to either exogenous LPS or to gut I/R (45 min ischemia, 5 h reperfusion). LPS elicited a dose-dependent (0.5–50 μg LPS/animal) increase in E-selectin expression (at 3 h) in LPS-sensitive mice, whereas LPS-insensitive mice were largely unresponsive. E-selectin expression was increased fivefold by I/R in the small bowel of both LPS-sensitive and -insensitive mice. These results indicate that, although exogenous LPS is capable of eliciting profound dose-dependent increases in E-selectin expression, endogenous LPS does not contribute significantly to I/R-induced expression of this endothelial cell adhesion molecule.
Nanoplasmonic imaging biosensor for digital detection of disease biomarkers (Conference Presentation) (2020)

We present a nanoparticle (NP) enhanced imaging-based plasmonic biosensing technique using gold nanohole arrays (Au-NHAs) that enables highly sensitive protein detection with single analyte resolution in a one-step sandwich immunoassay. By digital quantification of individual Au-NP bound molecules on large area plasmonic surface, the portable biosensor enables rapid and robust detection of disease biomarkers from patient serum in hospital settings. Using mass-scalable deep-UV lithography (DUVL) sensor fabrication and simple LED based imaging set-up in a microarray format, our novel technology provides a powerful tool for clinical biomarker detection in a highly multiplexed manner.
ChemInform Abstract: Accelerating Palladium‐Catalyzed C—F Bond Formation: Use of a Microflow Packed‐Bed Reactor. (2012)

Abstract The method allows an easy handling of large quantities of insoluble CsF with precise control over reaction conditions.
Induction of tier-2 neutralizing antibodies in mice with a DNA-encoded HIV envelope native like trimer (2022)

HIV Envelope (Env) is the main vaccine target for induction of neutralizing antibodies. Stabilizing Env into native-like trimer (NLT) conformations is required for recombinant protein immunogens to induce autologous neutralizing antibodies(nAbs) against difficult to neutralize HIV strains (tier-2) in rabbits and non-human primates. Immunizations of mice with NLTs have generally failed to induce tier-2 nAbs. Here, we show that DNA-encoded NLTs fold properly in vivo and induce autologous tier-2 nAbs in mice. DNA-encoded NLTs also uniquely induce both CD4 + and CD8 + T-cell responses as compared to corresponding protein immunizations. Murine neutralizing antibodies are identified with an advanced sequencing technology. The structure of an Env-Ab (C05) complex, as determined by cryo-EM, identifies a previously undescribed neutralizing Env C3/V5 epitope. Beyond potential functional immunity gains, DNA vaccines permit in vivo folding of structured antigens and provide significant cost and speed advantages for enabling rapid evaluation of new HIV vaccines.
Proactive security for mobile messaging networks (2006)

The interoperability of IM (Instant Messaging) and SMS (Short Messaging Service) networks allows users to seamlessly use a variety of computing devices from desktops to cellular phones and mobile handhelds. However, this increasing convergence has also attracted the attention of malicious software writers. In the past few years, the number of malicious codes that target messaging networks, primarily IM and SMS, has been increasing exponentially. Large message volume and number of users in these networks renders manual mitigation of malicious software nearly impossible. This paper proposes automated and proactive security models to protect messaging networks from mobile worms and viruses. First, we present an algorithm for automated identification of the most vulnerable clients in the presence of a malicious attack, based on interactions among the clients. The simplicity of our approach enables easy integration in most client-server messaging systems. Next, we describe a proactive containment framework that applies two commonly-used mechanisms---rate-limiting and quarantine---to the dynamically-generated list of vulnerable clients in a messaging network whenever a worm or virus attack is suspected. Finally, we evaluate the effectiveness of proactive security in a cellular network using data from a large real-life SMS customer network, and compare it against other existing approaches. Most messaging networks can implement our proposed framework without any major modification of their existing infrastructure.
La photographie filmique (2009)

http://cnriut09.univ-lille1.fr/articles/index.html
Ascaris in the paranasal sinuses: a reply (1997)

Ascaris in the paranasal sinuses: a reply J.F. Undo, J.F. Undo 1Department of Microbiology The University of the West Indies Kingston 7 Jamaica Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Naravane, A. Naravane 2Department of Basic Medical Sciences The University of the West Indies Kingston 7 Jamaica Search for other works by this author on: Oxford Academic PubMed Google Scholar L.A.D. Williams, L.A.D. Williams 2Department of Basic Medical Sciences The University of the West Indies Kingston 7 Jamaica Search for other works by this author on: Oxford Academic PubMed Google Scholar M.T. Gardener, M.T. Gardener 2Department of Basic Medical Sciences The University of the West Indies Kingston 7 Jamaica Search for other works by this author on: Oxford Academic PubMed Google Scholar C.K. Fletcher C.K. Fletcher 2Department of Basic Medical Sciences The University of the West Indies Kingston 7 Jamaica Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 91, Issue 5, September-October 1997, Page 623, https://doi.org/10.1016/S0035-9203(97)90054-7 Published: 01 October 1997
A Compact Digital Signature Scheme Based on the Module-LWR Problem (2021)

We propose a new lattice-based digital signature scheme MLWRSign by modifying Dilithium, which is one of the second-round candidates of NIST's call for post-quantum cryptographic standards. To the best of our knowledge, our scheme MLWRSign is the first signature scheme whose security is based on the (module) learning with rounding (LWR) problem. Due to the simplicity of the LWR, the secret key size is reduced by approximately 30% in our scheme compared to Dilithium, while achieving the same level of security. Moreover, we implemented MLWRSign and observed that the running time of our scheme is comparable to that of Dilithium.
Mission Architecture to Reach and Operate at the Focal Region of the Solar Gravitational Lens (2023)

We present initial results of an engineering study on the feasibility of a space mission to the focal region of the solar gravitational lens (SGL). The mission goal is to conduct exoplanet imaging operations at heliocentric distances in the range [Formula: see text] astronomical units (AU). Starting at 547.6 AU from the sun, light from an exoplanet located behind the sun is greatly amplified by the SGL. The objective is to capture this light and use it for multipixel imaging of an exoplanet up to 100 light years distant. Using a meter-class telescope, one can capture the data needed to produce images of the exoplanet with a surface resolution measured in tens of kilometers and to identify signs of habitability. The data are acquired pixel by pixel while moving an imaging spacecraft within the image. Given the long duration of the mission, decades to reach 900 AU, we address an architecture for the fastest possible transit time while reducing mission risk and overall cost. The mission architecture implements solar sailing technologies and in-space aggregation of modularized functional units to form mission capable spacecraft. The study reveals elements of such a challenging mission, but it is nevertheless found to be feasible with technologies that are either extant or in active development.
The Risk Factors of Acute Cellular Rejection in Adult Living Donor Liver Transplantation: Doubting the Value of Positive Lymphocytotoxic Cross-match Results (2009)

Background: The influence of lymphocytotoxic cross-match results on acute cellular rejection in adult living donor liver transplantation (LDLT) has not been well examined. Therefore, in this study, we investigated the risk factors of acute rejection, including positive lymphocytotoxic cross-match results.
Toward Implementing an MRI-Based PET Attenuation-Correction Method for Neurologic Studies on the MR-PET Brain Prototype (2010)

A DUTE MRI-based AC method considering all these factors was implemented. Preliminary results suggest that this method could potentially be as accurate as the segmented CT method and could be used for quantitative neurologic MR-PET studies.
Variable frequency-controlled, zero-voltage switching, current-fed, single-ended DC-to-AC converter with output isolation (2002)

A zero-voltage switching (ZVS), current-fed, single-ended DC-to-AC power converter with output isolation, symmetrical AC output voltage and transformer volt-second balance is proposed. Using variable switching frequency control and operating its two active complementary switches at 50% duty ratio, the power converter regulates output power via an LCC resonant link circuit. ZVS is achieved by a resonant circuit mainly formed by the switch parasitic capacitance and transformer magnetizing inductance. Continuous input current and near-sinusoidal output voltage and current result in low electromagnetic interference.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
An optical method for measuring metal surface temperature in harsh environment conditions (2010)

Commercially available instruments for measuring and monitoring surface temperature of metal parts are very limited and often unsuitable for applications at harsh environment conditions. Another major challenge is to measure temperature of a rotating surface, as it is very difficult to take an electrical signal out from rotating parts. A novel optical reflectance based non-contact temperature measurement technique is discussed which can be used for temperature measurement on metal surfaces. The optical reflectivity of metals is known to depend on metal temperature and wavelength of the incident light. An increase in metal temperature resulted in the change (increase or decrease depending on particular metal properties) of reflected laser power from the metal surface. This also depends on the surface geometries of the metal surface being measured. We have shown that the sensitivity of the temperature measured depends on the angle of incidence, surface topology and surface properties of the object.
Incidence of arthritis and autoreactivity of anti-collagen antibodies after immunization of DBA/1 mice with heterologous and autologous collagen II. (1985)

Native type II collagens of rat, chick, bovine, human and murine origin have been used for immunization of male and female DBA/1 mice of different ages. The four heterologous collagens were able to induce arthritis in both male and female mice although the incidence of arthritis was higher in males. The onset of arthritis was sudden with severe lesions starting to appear 5- to 6-weeks after immunization. Mouse collagen II, on the other hand, caused arthritis exclusively in males. The onset of arthritis was in the latter case less dramatic and usually delayed until 12- to 14-weeks post immunization. Antibody production against both the immunogen and other type II collagens, including mouse collagen was seen in both arthritic and non-arthritic animals, and antibody titres against both the collagen used for immunization and mouse collagen were higher in the sera from arthritic than in identically immunized non-arthritic animals. Total amounts of auto-anticollagen II antibodies were, however, more dependent on which collagen preparation was used for immunization than on whether the immunized mice developed arthritis or not. These results indicate that arthritis induction in mice is not dependent solely on the levels of autoreactive anti-collagen II antibodies.
Use of a cytotoxic peptide as an immunotherapeutic agent in the treatment of metastatic breast cancer (VAC13P.1134) (2015)

Abstract Breast cancer is a challenge for immunotherapy because of its genetic heterogeneity and decreased immunogenicity, which impedes the use of immune checkpoint blockade. A promising approach is to generate dying cancer cells that operate like a vaccine to induce a tumor-specific immune response and eradicate residual cancer cells. This is termed immunogenic cell death (ICD) and is characterized by a unique molecular signature that stimulates immunity. To develop a novel ICD agent for cancer immunotherapy, our group discovered a therapeutic peptide, CT20p, and a nanotechnology-based platform to concentrate CT20p in breast tumors. Treatment of mice with nanomolar amounts of CT20p caused tumor regression, and dying breast cancer cells expressed markers characteristic of ICD: calreticulin (Crt) and heat shock protein (HSP)-70. The intracellular target of CT20p is a protein called chaperonin-containing T-complex (CCT) that folds actin and tubulin. CCT was overexpressed in breast cancer cells susceptible to CT20p. In contrast, normal epithelial cells, macrophages or NK cells, which have low levels of CCT, were unaffected by CT20p. Breast cancer cells treated with CT20p displayed alterations in IRE1 and PERK, mediators of the unfolded protein response (UPR) that are upstream drivers of ICD signals. Hence, CT20p-treated breast cancer cells were more effectively killed by NK cells and ingested by phagocytes, demonstrating that CT20p is a robust stimulator of innate immunity.
Optical properties and thermal characteristics of the floating zone grown Nd:LuVO4 crystals (2005)

High-quality Nd:LuVO4 crystals were successfully grown by the floating zone method. Large absorption coefficient of 64cm-1 was observed at 808nm with 1at.% Nd doped crystal. The thermal conductivity of the crystal was measured with temperature wave analysis.
Optical and electrical tuning of the frequency in self-oscillating multiple shallow quantum-well diodes (1999)

We have studied photoinduced self-oscillation characteristics in GaAs/AlGaAs multiple shallow quantum-well diodes as a function of bias voltage and laser power. Under the illumination of a laser of wavelength corresponding to the exciton absorption energy, the I–V curve of the diode revealed a large negative differential conductance region where the electrical and optical oscillations were observed in the same phase. The oscillation frequency was widely tuned by either bias voltage or laser power, and this demonstrates a large potential of the device scheme for the electrical and optical signal generators with wide frequency tunability.