gebhart/patrepeval huggingface dataset:
INVESTIGATION OF SPECTRAL SENSITIZATION. II. AN INVESTIGATION OF THE ELECTRON SPIN RESONANCE SPECTRA OF DONOR-ACCEPTOR COMPLEXES BETWEEN SENSITIZING DYES AND ACCEPTOR COMPOUNDS1 (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTINVESTIGATION OF SPECTRAL SENSITIZATION. II. AN INVESTIGATION OF THE ELECTRON SPIN RESONANCE SPECTRA OF DONOR-ACCEPTOR COMPLEXES BETWEEN SENSITIZING DYES AND ACCEPTOR COMPOUNDS1J. E. LuValle, A. Leifer, M. Koral, and M. CollinsCite this: J. Phys. Chem. 1963, 67, 12, 2635–2639Publication Date (Print):December 1, 1963Publication History Published online1 May 2002Published inissue 1 December 1963https://doi.org/10.1021/j100806a031RIGHTS & PERMISSIONSArticle Views68Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (647 KB) Get e-Alerts
In vitro assessment of heart valve bioprostheses by cardiovascular magnetic resonance: four-dimensional mapping of flow patterns and orifice area planimetry☆ (2011)

CMR allowed for a detailed interrogation of the fluid dynamics of various heart valve bioprostheses in a pulsatile flow model. It is an attractive tool to define proprietary reference values of the orifice area under standardized conditions and provides novel information regarding the flow pattern in proximity to the prosthesis.
The Pseudorandomness of Elastic Block Ciphers (2005)

We investigate elastic block ciphers, a method for constructing variable length block ciphers, from a theorectical perspective. We view the underlying structure of an elastic block cipher as a network, which we refer to as an elastic network, and analyze the network in a manner similar to the analysis performed by Luby and Rackoff on Fesitel networks. We prove that a three round elastic network is a pseudorandom permutation and a four round network is a strong pseudorandom permutation when the round functions are pseudorandom permutations.
Rapid, Wet Chemical Fabrication of Radial Junction Electroluminescent Wires (2018)

A wet chemical process involving two electrodeposition steps followed by a solution casting step, the "EESC" process, is described for the fabrication of electroluminescent, radial junction wires. EESC is demonstrated by assembling three well-studied nanocrystalline (or amorphous) materials: Au, CdSe, and poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS). The tri-layered device architecture produced by EESC minimizes the influence of an electrically resistive CdSe emitter layer by using a highly conductive gold nanowire that serves as both a current collector and a negative electrode. Hole injection, at a high barrier CdSe-PEDOT:PSS interface (ϕ<sub>h</sub> ≈ 1.1 V), is facilitated by a contact area that is 1.9-4.7-fold larger than the complimentary gold-CdSe electron-injecting contact (ϕ<sub>e</sub> ≈ 0.6 V), contributing to low-voltage thresholds (1.4-1.7 V) for electroluminescence (EL) emission. Au@CdSe@PEDOT:PSS wire EL emitters are 25 μm in length, amongst the longest so far demonstrated to our knowledge, but the EESC process is scalable to nanowires of any length, limited only by the length of the central gold nanowire that serves as a template for the fabrication process. Radial carrier transport within these multishell wires conforms to the back-to-back diode model.
Identification of three critical acidic residues of poly(ADP-ribose) glycohydrolase involved in catalysis: determining the PARG catalytic domain (2005)

PARG [poly(ADP-ribose) glycohydrolase] catalyses the hydrolysis of alpha(1''-->2') or alpha(1'''-->2'') O-glycosidic linkages of ADP-ribose polymers to produce free ADP-ribose. We investigated possible mechanistic similarities between PARG and glycosidases, which also cleave O-glycosidic linkages. Glycosidases typically utilize two acidic residues for catalysis, thus we targeted acidic residues within a conserved region of bovine PARG that has been shown to contain an inhibitor-binding site. The targeted glutamate and aspartate residues were changed to asparagine in order to minimize structural alterations. Mutants were purified and assayed for catalytic activity, as well as binding, to an immobilized PARG inhibitor to determine ability to recognize substrate. Our investigation revealed residues essential for PARG catalytic activity. Two adjacent glutamic acid residues are found in the conserved sequence Gln755-Glu-Glu757, and a third residue found in the conserved sequence Val737-Asp-Phe-Ala-Asn741. Our functional characterization of PARG residues, along with recent identification of an inhibitor-binding residue Tyr796 and a glycine-rich region Gly745-Gly-Gly747 important for PARG function, allowed us to define a PARG 'signature sequence' [vDFA-X3-GGg-X6-8-vQEEIRF-X3-PE-X14-E-X12-YTGYa], which we used to identify putative PARG sequences across a range of organisms. Sequence alignments, along with our mapping of PARG functional residues, suggest the presence of a conserved catalytic domain of approx. 185 residues which spans residues 610-795 in bovine PARG.
A vertically integrated tunable UHF filter (2010)

A novel, vertically integrated filter design is used to produce a tunable UHF filter in a polymer based substrate. The filter is a sub band of a widely tunable narrowband preselect filter array and makes use of unused substrate space within the array to increase the overall tuning range of the array while keeping the substrate volume constant. This paper will discuss the use of mixed three dimensional electromagnetic and SPICE simulation in the design of the tunable filter. The fabrication of the filter using standard PCB fabrication techniques will be described and measured performance of the filter will be compared to the simulated response. High inductor and capacitor Q's were required to meet insertion loss specifications over the entire tuning range of the filter. The design and simulation of vertically integrated coupled parallel plate inductors and the careful design of the combination of static capacitors and tuning varactors to achieve the desired tuning and filter response will be highlighted.
Figure S2 from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues (2023)

&lt;p&gt;Dissociation constants for targeted vesicle constructs.&lt;/p&gt;
Design and implementation of a multifrequency near-infrared diffuse optical tomography system (2006)

The design and implementation of a multifrequency and multispectral diffuse optical tomography system is described. Four wavelengths are utilized: 665, 785, 808, and 830 nm. The system is based on a network analyzer, which provides rf modulation signals for the laser diodes, as well as measures the amplitude and the phase of the detected signals. Six different modulation frequencies ranging from 110 to 280 MHz are used. The details of instrumentation, calibration, data acquisition, and performance of the system are given. A finite element algorithm is used to solve the diffusion equation, and an inverse solver based on this forward solver is implemented to calculate the absorption and scattering maps from the acquired data. Data acquisition for one wavelength is completed in less than 2.5 min for a single modulation frequency. The measurement repeatability is 0.5% in ac intensity and 0.2 deg in phase. The performance of the system is evaluated with phantom studies. A multifrequency reconstruction algorithm is used, in which a single absorption and scattering image pair is obtained using the whole dataset obtained at different modulation frequencies. It is shown that the multifrequency reconstruction approach provides superior image quality compared to the single frequency counterpart.
Countering DoS attacks with stateless multipath overlays (2005)

Indirection-based overlay networks (IONs) are a promising approach for countering distributed denial of service (DDoS) attacks. Such mechanisms are based on the assumption that attackers will attack a fixed and bounded set of overlay nodes causing service disruption to a small fraction of the users. In addition, attackers cannot eaves-drop on links inside the network or otherwise gain information that can help them focus their attacks on overlay nodes that are critical for specific communication flows. We develop an analytical model and a new class of attacks that considers both simple and advanced adversaries. We show that the impact of these simple attacks on IONs can severely disrupt communications. We propose a stateless spread-spectrum paradigm to create per-packet path diversity between each pair of end-nodes using a modified ION access protocol. Our system protects end-to-end communications from DoS attacks without sacrificing strong client authentication or allowing an attacker with partial connectivity information to repeatedly disrupt communications. Through analysis, we show that an Akamai-sized overlay can withstand attacks involving over 1.3M "zombie" hosts while providing uninterrupted end-to-end connectivity. By using packet replication, the system can resist attacks that render up to 40% of the nodes inoperable. Surprisingly, our experiments on PlanetLab demonstrate that in many cases end-to-end latency decreases when packet replication is used, with a worst-case increase by a factor of 2.5. Similarly, our system imposes less than 15% performance degradation in the end-to-end throughput, even when subjected to a large DDoS attack.
Improved Slope Efficiency of InAs/InP Quantum Dash Mode-Locked Lasers (2022)

This paper presents the performance of InAs/InP quantum dash (QDash) mode-locked lasers with different number of QDash layers. Decreasing the number of QDash layers leads to a markedly reduced threshold and improved slope efficiency. This provides insight toward the application of QDash mode-locked laser to the field of optical transmission for all-optical networks.
Hormonal Therapy of Cryptorchidism (1986)

RAJFER, JACOB; HANDELSMAN, DAVID J.; SWERDLOFF, RONALD S.; HURWITZ, RICHARD; KAPLAN, HAROLD; VANDERGAST, THOMAS; EHRLICH, RICHARD M. Author Information
Schäden wälzbeanspruchter DLC-Schichten auf Stahlsubstraten unterschiedlicher Härte (2005)

Paraffinöl geschmierte Wälztests wurden an extrem harten Diamantschichten auf hartem SSiC Substrat, unterschiedlichen, harten DLC-Schichten auf 100Cr6 Substraten (HRC60) sowie ausgewählten DLC-Schichten auf ungehärtetem Stahl (HRC 20) durchgeführt. Die Wälztests wurden in einem Zweischeibentribometer vom Typ Amsler bei einer anfänglichen, maximalen Flächenpressung nach Hertz von P0=2,3 GPa ausgeführt. Als Abbruchkriterium für die Tests wurde das Erreichen von n=1.000.000 Überrollungen (Langzeittests n=10.000.000 Überrollungen) oder das Auftreten einer Schädigung mit einer zusammenhängenden Fläche von A>1 mm2 festgelegt. Die Wälztests zeigten, dass das harte SSiC Substrat zwar eine stützende Wirkung auf die Diamantschicht hat, diese aber aufgrund von Rissen im Substrat versagte. Ferner gibt es wenigstens zwei DLC-Schichten, die, aufgebracht auf 100Cr6 Scheiben (HRC60), den Wälztests bis n=10.000.000 Überrollungen ohne nennenswerte Schäden widerstanden. Diese Schichten passten sich auch den Verformungen des weichen, stickstofflegierten Stahls (HRC20) an, ohne das es zu größeren Abplatzungen kam (A>1 mm2). Damages of slip-rolling tested DLC coatings on steel substrates of different hardness Extremely hard diamond coatings on hard SSiC substrates, various hard DLC coatings on 100Cr6 substrates (HRC60) as well as selected DLC coatings on unhardened steel substrates (HRC20) were tested under slip-rolling conditions. Unadditivated paraffin oil was used as a lubricant. The tests were carried out in an Amsler type twin disc tester at initial maximum pressures of P0=2.3 GPa according to Hertz. The tests were terminated after n=1.000.000 revolutions (endurance tests: n=10.000.000 revolutions) or if a coherent damaged area of A>1 mm2 occurred. The slip-rolling tests showed that the SSiC had a supportive influence on the diamond coatings which, however, failed due to fractures in the substrate. At least two of the DLC coatings on 100Cr6 substrates (HRC60) withstood the slip-rolling test for up to n=10.000.000 revolutions with nearly no visible damage. These coatings deposited onto a soft, nitrogen alloyed steel (HRC20) were able to adjust to the deformation of the substrate without major damaged areas (A>1 mm2).
Reduction of motor overvoltage fed by PWM AC drives using a universal model (2010)

An induction motor model construction and the validation of the model response to a filtering technique is analyzed in this paper. The filter is connected to the rotating machine terminals in order to suppress overvoltages due to the long cables and high frequency pulses of the inverter. With the help of high frequency measurements made by the authors on a 1.1kW induction motor, an accurate simulation with Matlab Simulink™ based on differential mode analysis, is made. The simulation shows realistic results for the determination of the filter parameters among different values of rise time and cable length.
Controlling the Adsorption and Reactivity of DNA on Gold (2003)

Due to its coding nature, the many chemical and enzymatic manipulations that it can undergo, and its relative stability, DNA is being used as a scaffold and a building block outside the cellular context. The mode by which the DNA is connected to a solid surface is in the heart of technological advancements, such as DNA chips and biosensors. The desire is to connect the DNA to a given surface in a predesigned manner, tailored to any device specifications. In this work, DNA molecules were adsorbed specifically on gold surfaces. The specificity of the adsorption was controlled by a novel approach, in which the gold surface was first blocked with a hydrophobic layer (C18−SH) to various extents, followed by the adsorption of thiolated DNA. The technique was applied both for short and for long strands of DNA. We show that the reactivity of the thiolated short DNA in a ligation reaction is enhanced by more than an order of magnitude by the presence of the alkylthiol layer. Due to the hydrophobic and insulating nature of the C18−SH layer, this blocking method is advantageous for electronic measurements.
CT Reveals a High Incidence of Osseous Abnormalities in Hips with Labral Tears (2010)

Level IV, diagnostic study. See Guidelines for Authors for a complete description of levels of evidence.
10 Years of SYNTAX (2023)

The SYNTAX trial randomized patients equally eligible for coronary artery bypass grafting or percutaneous coronary intervention using the Heart Team approach. The SYNTAXES study achieved a follow-up rate of 93.8% and reported the 10-year vital status. Factors associated with increased mortality at 10 years were pharmacologically treated diabetes mellitus, increased waist circumference, reduced left ventricular function, prior cerebrovascular and peripheral vascular disease, western Europe and North American descent, current smoking, chronic obstructive pulmonary disease, elevated C-reactive protein, anemia, and an increase in HbA1c. Procedural factors associated with higher 10 years mortality include periprocedural myocardial infarction, extensive stenting, small stents, ≥1 heavily calcified lesion, ≥1 bifurcation lesion, residual SYNTAX score >8, and staged percutaneous coronary intervention. Optimal medical therapy at 5 years, use of statins, on-pump coronary artery bypass grafting, multiple arterial grafts, and higher physical component score and mental component score were associated with lower mortality at 10 years. Numerous scores and prediction models were developed to help individualize risk assessment. Machine learning has emerged as a novel approach for developing risk models.
Genetic evidence and historical theories of the Asian and African origins of the present Malagasy population (2021)

The origin of the Malagasy population has been a subject of speculation since the 16th century. Contributions of African, Asian, Indian, Melanesian, Arabic and Persian populations have been suggested based on physical and cultural anthropology, oral tradition, linguistics and later also by archaeology. In the mid-20th century, increased knowledge of heredity rules and technical progress enabled the identification of African and Asian populations as main contributors. Recent access to the genomic landscape of Madagascar demonstrated pronounced regional variability in the relative contributions of these two ancestries, yet with significant presence of both African and Asian components throughout Madagascar. This article reviews the extent to which genetic results have settled historical questions concerning the origin of the Malagasy population. After an overview of the early literature, the genetic results of the 20th and 21th centuries are discussed and then complemented by the latest results in genome-wide analyses. While there is still much uncertainty regarding when, how and the circumstances under which the ancestors of the modern Malagasy population arrived on the island, we propose a scenario based on historical texts and genomic results.
Table S1 and S2 from HIF2α-Targeted RNAi Therapeutic Inhibits Clear Cell Renal Cell Carcinoma (2023)

&lt;p&gt;DPC characteristics and Clinical chemistry&lt;/p&gt;
Probing Novel 1‐Aza‐9‐oxafluorenes as Selective GSK‐3β Inhibitors (2007)

Within the histopathology of Alzheimer's disease (AD) certain hallmarks are beeing observed. The occurance of protein deposits belong to such characteristic features. Such deposits can be found extracellular as beta-amyloid (Abeta) plaques and intracellular as neurofibrillary tangles (NFTs). In the search for novel AD therapeutics it became of great interest to investigate the formation of NFTs and their contribution to the AD symptomatic. NFTs consist of hyperphosphorylated tau protein. Within the phosphorylation process of tau protein two kinases are of great importance: cyclin dependent kinase 5 (cdk5) and its truncated regulatory subunit p25 and glycogen synthase kinase 3beta (GSK-3beta). The role of both kinases within the NFT formation process is still under debate. To better understand the pathophysiological process highly selective inhibitors of both kinases are of value. Known inhibitors lack the necessary selectivity. We developed novel 1-aza-9-oxafluo-renes as selective GSK-3beta inhibitors. Structure-activity relationships of a series of 4-phenyl substituted derivatives are discussed. Variation of the 3-side chain led to selective carbonyl amide derivatives with selectivity factors of more than 100 at the tested ATP competitor concentrations. Such selectivities permit specific investigation of the role of GSK-3beta within the NFT formation processes.
Production of Proteins by Mammalian Cells Using Dominant Selectable and Amplifiable Markers (2020)

When one desires to produce a protein that is most likely to be successfully synthesized in a mammalian cell, the recommended process depends on several different criteria, most importantly, the amount of the protein that is required. Microgram to milligram quantities of either cytoplasmic or secreted proteins can most efficiently be produced by transient expression using virus-derived vectors that produce a lytic infection in mammalian cells. A higher percentage of stable clones can be achieved by several different methods, but this is not necessary for isolating clones with high level expression. Cells can be seeded directly following introduction of DNA into 96-well dishes, and then selected for a marker gene. If a higher level of expression is desired, a group of high level expressing clones are individually selected for gene amplification.
Plasmon-Coupled Photocapacitor Neuromodulators (2020)

Efficient transduction of optical energy to bioelectrical stimuli is an important goal for effective communication with biological systems. For that, plasmonics has a significant potential via boosting the light-matter interactions. However, plasmonics has been primarily used for heat-induced cell stimulation due to membrane capacitance change (i.e., optocapacitance). Instead, here, we demonstrate that plasmonic coupling to photocapacitor biointerfaces improves safe and efficacious neuromodulating displacement charges for an average of 185% in the entire visible spectrum while maintaining the faradic currents below 1%. Hot-electron injection dominantly leads the enhancement of displacement current in the blue spectral window, and the nanoantenna effect is mainly responsible for the improvement in the red spectral region. The plasmonic photocapacitor facilitates wireless modulation of single cells at three orders of magnitude below the maximum retinal intensity levels, corresponding to one of the most sensitive optoelectronic neural interfaces. This study introduces a new way of using plasmonics for safe and effective photostimulation of neurons and paves the way toward ultrasensitive plasmon-assisted neurostimulation devices.
Correlation of regional brain atrophy with clinical scores in Multiple Sclerosis. (P6.157) (2015)

Background: It is accepted that brain atrophy is a surrogate marker for clinical parameters in terms of disability progression in MS. But data on correlation of global brain atrophy and clinical parameters are inconsistent or missing for regional brain atrophy. One reason might be the clinical but not volumetric compensating mechanisms in the white matter (WM) in early disease stages. Materials/methods: The design is crossectional, controlled, prospective and blinded. 108 consecutive patients (32 MS patients without disease modifying therapy (DMT) and 76 with DMT) were enrolled. The cohort was subdivided in 2 groups with global WM atrophy below median (WMbelow) and above median (WMabove) respectively. A normative database of 27 healthy subjects preexisted. The clinical scores were EDSS, SDMT, DEMTEC and HADS. The brain atrophy data was aquired by a 3T MRI, high resolution T1-weighted sequence (MPRAGE), and regional voxel wise two sample T test checking each patient and the normative database for any volume deviations. Pearson correlation was performed on regional and global brain atrophy data with the clinical scores. Results: For all clinical parameters the correlation coefficients (cc) were significant higher in the WMbelow. For example the correlation of EDSS with corpus callosum is 0.25 in WMabove and 0.5 in WMbelow. For the thalamus the corresponding values were 0.2 and 0.55, for the temporal GM we found 0.02 and 0.50. The correlation of DEMTEC with cortical GM regions (frontal, temporal, parietal and occipital) were 0.0-0.2 in WMabove and 0.4-0.47 in WMbelow. Conclusion: In MS the clinical correlations with regional brain atrophy depend on the amount of WM damage. We conclude that early GM atrophy remains subclinical until loss of compensating remyelination with consecutive loss in the WM occurs.