gebhart/patrepeval huggingface dataset:
Differential effects of peritoneal and hemodialysis on circulating regulatory T cells one month post initiation of renal replacement therapy (2020)

Backgroundː Chronic kidney disease stage G5 (CKD G5) patients show an activated but impaired immune system. One function of the FOXP3<sup>+</sup> regulatory T (Treg) cells is to preserve tolerance to self while maintaining the ability to fight infectious agents. The aim of this pilot study is to evaluate longitudinal changes in Treg cells before and 1 month after the first dialysis treatment. Materials and methodsː CKD G5 patients not yet on dialysis were enrolled and started on hemodialysis (HD) or peritoneal dialysis (PD). Tregs were analyzed by flow cytometry at two time points: T0 (before the first dialysis treatment) and T1 (1 month after the first dialysis session). Wilcoxon test for dependent samples was used to compare the mean percentage difference between T0 and T1: Δ% = 100 × [(T1 - T0) / T0]. Resultsː 21 patients were enrolled: 8 on HD and 13 on PD. The proportion of total lymphocytes (low side scatter lymphocyte gate) and T lymphocytes (in the CD3<sup>+</sup>CD4<sup>+</sup> gate) did not change significantly 1 month after the start of dialysis in both groups. Treg cells (as CD25<sup>+</sup>FOXP3<sup>+</sup>, FOXP3<sup>+</sup>, or CD25<sup>+</sup>CD127<sup>-</sup>), analyzed as percentage of the lymphocyte gate, showed a significant increase post PD (CD25<sup>+</sup>FOXP3<sup>+</sup>: median = 35.92; p = 0.0425; FOXP3<sup>+</sup>: median = 30.85; p = 0.0479 and CD25<sup>+</sup>CD127<sup>-</sup>: median = 23.71; p = 0.0215). The same populations, did not change 1 month after the first dialysis session. Conclusionː Our study is the first to evaluate longitudinal effects of dialysis on Treg cells in uremia and suggests that PD was more effective in increasing Treg levels 1 month post initiation of dialysis and may contribute to improvement of inflammatory status. Thus, PD may contribute to better outcomes for patients with renal dysfunction, also maintaining homeostasis of peritoneal and renal tissues.
Discriminative Nonparametric Latent Feature Relational Models with Data Augmentation (2015)

We present a discriminative nonparametric latent feature relational model (LFRM) for link prediction to automatically infer the dimensionality of latent features. Under the generic RegBayes (regularized Bayesian inference) framework, we handily incorporate the prediction loss with probabilistic inference of a Bayesian model; set distinct regularization parameters for different types of links to handle the imbalance issue in real networks; and unify the analysis of both the smooth logistic log-loss and the piecewise linear hinge loss. For the nonconjugate posterior inference, we present a simple Gibbs sampler via data augmentation, without making restricting assumptions as done in variational methods. We further develop an approximate sampler using stochastic gradient Langevin dynamics to handle large networks with hundreds of thousands of entities and millions of links, orders of magnitude larger than what existing LFRM models can process. Extensive studies on various real networks show promising performance.
Association of age with left ventricular volumes, ejection fraction and concentricity: the Framingham heart study (2013)

Background Left ventricular (LV) parameters may vary with aging, but concomitant disease can obscure relationships between age and LV size, mass and function. CMR provides reproducible measures of LV volumes, mass, and ejection fraction (EF), but manual analyses are time consuming. Automated border detection (ABD) methods may decrease analytical burden. We sought to examine the effect of greater age on LV volumes, mass, EF and concentricity in a large cohort of healthy adults free of clinical cardiovascular disease and hypertension using ABDassisted methods.
Regioselective Suzuki Coupling of Benzofuran or Benzothiophene Boronic Acids and Dibromo Substituted Naphthalenes: Synthesis of a Potent Inhibitor of Plasminogen Activator Inhibitor‐1. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A T cell receptor (TCR) antagonist competitively inhibits serial TCR triggering by low‐affinity ligands, but does not affect triggering by high‐affinity anti‐CD3 antibodies (1997)

It has been demonstrated that modified peptides which fail to induce detectable T cell responses can act as T cell receptor (TCR) antagonists when presented together with agonist by the same antigen-presenting cell (APC). We report that a TCR antagonist competitively inhibits TCR triggering induced by low-affinity ligands such as agonistic peptides or bacterial superantigens. However, the same antagonist cannot inhibit TCR triggering and T cell activation induced by high-affinity anti-CD3 antibodies that engage most TCR at once. These results indicate that TCR antagonists inhibit T cell responses by interfering with the ongoing process of serial triggering, rather than by delivering an inhibitory signal to T cells.
Quarterly Research Performance Progress Report (2015 Q3). Ultrasonic Phased Arrays and Interactive Reflectivity Tomography for Nondestructive Inspection of Injection and Production Wells in Geothermal Energy Systems (2015)

For the past quarter, we have placed our effort in implementing the first version of the ModelBased Iterative Reconstruction (MBIR) algorithm, assembling and testing the electronics, designing transducers mounts, and defining our laboratory test samples. We have successfully developed the first implementation of MBIR for ultrasound imaging. The current algorithm was tested with synthetic data and we are currently making new modifications for the reconstruction of real ultrasound data. Beside assembling and testing the electronics, we developed a LabView graphic user interface (GUI) to fully control the ultrasonic phased array, adjust the time-delays of the transducers, and store the measured reflections. As part of preparing for a laboratory-scale demonstration, the design and fabrication of the laboratory samples has begun. Three cement blocks with embedded objects will be fabricated, characterized, and used to demonstrate the capabilities of the system. During the next quarter, we will continue to improve the current MBIR forward model and integrate the reconstruction code with the LabView GUI. In addition, we will define focal laws for the ultrasonic phased array and perform the laboratory demonstration. We expect to perform laboratory demonstration by the end of October 2015.
A 2 µm poly-gate CMOS analog/digital array (1984)

The development of a 2μm poly-gate CMOS array which combines digital gate array together with stacked-layout analog capability will be covered. Up to 10 sections of a biquadratic switched-capacitor filter can be implemented in the analog section.
1130: Combining Urine Output and Intra-Abdominal Pressures Predict Acute Kidney Injury Early (2020)

Prabhakar, Amit; Stanton, Kelly; Burnett, Daniel; Egan, Katherine; Keeling, Brent; Moll, Vanessa Author Information
Subretinal gene replacement rescues retinal phenotype in BBS10 mouse (2021)

Purpose : To assess toxicity and efficacy of subretinal gene replacement in BBS10 mice. Overexpression toxicity in BBS1 mice occurred with gene therapy;BBS1 is part of the BBSome, while BBS10 is part of the BBS/CCT chaperonin complex. Methods : A knock out mouse model of Bardet Biedl Syndrome type 10 (BBS10) was developed. AAV2/5-Bbs10FLAG and AAV2/Anc80-Bbs10FLAG vectors were created. Subretinal 2 ul injections of 1E12, 2E12 or 4E12VG/ml were performed in 62 Bbs10-/-and 12 WT mice. Immunoblotting and immunohistochemistry were utilized to assess protein production and restoration of Bbs10 gene function. ERG, OCT, and visually guided swim assay (VGSA) were used to assess efficacy. Due to COVID-19, long term data was collected only for 12 mice treated with 2E9 or 4E9 AAV2/Anc80-Bbs10FLAG and 3 controls. Results : Neither AAV2/5-Bbs10FLAG nor AAV2/Anc80-Bbs10FLAG were toxic in WT or Bbs10-/-. One month after injection, FLAG was detected in treated, but not untreated Bbs10-/-eyes, documenting presence of BBS10 protein.BBS7,undetectable or barely detectable within photoreceptor cilia in untreated Bbs10 eyes,was present in photoreceptor cilia in treated Bbs10 eyes.VGSA was partially rescued via either AAV2/5 or AAV2/Anc80 treated at P30-P60 when tested in the dark at age 3.5 months(p= 1.36E005)and in both light and dark at age 7 months (p=. <0.0001 light;p= 0.0094 dark). VGSA improvement endured in AAV2/Anc80 treated mice at 9-12 months old(p=0.0113). Treated eyes had higher amplitude ERG than untreated fellow eyes at 10-11.5 months old (highest p=0.0425). OCT at 11-14 months demonstrated presence of outer nuclear layer in 5/11 treated eyes compared to 0/11 untreated fellow eyes and 0/6 untreated control eyes. 5Hz flicker response was not present at any age in untreated Bbs10 (n=18 eyes), but developed in 9 of 12 eyes treated before 4 months old. 4 of 12 treated eyes still had recordable 5 Hz at 11-14 mos, all treated with 4E9. Histology at 11 months demonstrated robust ONL, inner and outer segments with numerous cones, and normal localization of STX3 adjacent to the injection site in 2 treated eyes. Conclusions : In the Bbs10 mouse subretinal gene therapy with AAV2/Anc80-Bbs10FLAG rescues retinal phenotype . Lack of 5 Hz flicker ERG response in untreated eyes was rescued with early high titer gene therapy suggesting that BBS10 plays an early role in cone development and/or function. Human BBS10 clinical trials are needed.
A Cooperative Defense Framework Against Application-Level DDoS Attacks on Mobile Edge Computing Services (2021)

Mobile edge computing (MEC), extending computing services from cloud to edge, is recognized as one of key pillars to facilitate real-time services and tackle backhaul bottleneck. However, it is not economically efficient to attach intensive security appliances to every MEC node to defend application-level DDoS attacks and ensure the availability of services. Thus, we explore the elasticity of security defense among MEC nodes by proposing a COoperative DEfense ( <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CODE</i> ) framework for MEC, referred to as <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CODE4MEC</i> . CODE4MEC aims to adapt to traffic changes by coordinating container-carried defensive resources among cooperative MEC nodes in an automatic way. Towards this aim, we propose four control plane functions to enable a life-cycle management for CODE4MEC, namely, CODE triggering, scheduling, coordination and releasing. However, an effective CODE4MEC requires non-trivial algorithmic schemes, in particular for CODE scheduling and coordination functions. We thus design an online combinatorial auction mechanism for real-time CODE scheduling, and prove a tighter performance bound relative to prior arts. As for CODE coordination, a flow-based traffic and context information coordination scheme is proposed to enable classical defense schemes to work properly and efficiently. Finally, using a combination of real testbed and simulation evaluations, we validate the effectiveness of CODE4MEC.
Search for B−L R-parity-violating top squarks in s=13  TeV pp collisions with the ATLAS experiment (2018)

A search is presented for the direct pair production of the stop, the supersymmetric partner of the top quark, that decays through an R-parity-violating coupling to a final state with two leptons and two jets, at least one of which is identified as a b-jet. The data set corresponds to an integrated luminosity of 36.1 fb -1 of proton-proton collisions at a center-of-mass energy of ffiffi ffi s p 13 TeV, collected in 2015 and 2016 by the ATLAS detector at the LHC. No significant excess is observed over the Standard Model background, and exclusion limits are set on stop pair production at a 95% confidence level. Lower limits on the stop mass are set between 600 GeV and 1.5 TeV for branching ratios above 10% for decays to an electron or muon and a b-quark.
Weight Sensation in Virtual Environments Using a Haptic Device With Air Jets (2003)

The research presented in this paper is the design and implementation of a force feedback hand master called AirGlove. The device uses six ports arranged in a Cartesian coordinate frame setting to apply a point force to the user’s hand. Compressed air is exhausted through the ports, creating thrust forces. The magnitude and direction of the resultant force are controlled by changing the flow rate of the air jets and by activating different ports. The AirGlove can apply an arbitrary point force to the user’s hand. However, the main goal of this research is to reflect gravitational forces to the user so that sensation of weight of a virtual object can be created. After introduction of the main concept of the AirGlove, the paper presents design and implementation details of the device. Integration of the AirGlove with a virtual assembly system called VADE is explained next. Finally, details of experiments with the device are presented and discussed. Results indicate that users wearing the AirGlove can feel a minimum mass of about 100 grams (∼1N weight) and the device can create a fairly realistic weight sensation.
Progesterone receptor modulates ERα action in breast cancer (2020)

Progesterone receptor (PR) expression is employed as a biomarker of estrogen receptor-α (ERα) function and breast cancer prognosis. We now show that PR is not merely an ERα-induced gene target, but is also an ERα-associated protein that modulates its behaviour. In the presence of agonist ligands, PR associates with ERα to direct ERα chromatin binding events within breast cancer cells, resulting in a unique gene expression programme that is associated with good clinical outcome. Progesterone inhibited estrogen-mediated growth of ERα+ cell line xenografts and primary ERα+ breast tumour explants and had increased anti-proliferative effects when coupled with an ERα antagonist. Copy number loss of PgR is a common feature in ERα+ breast cancers, explaining lower PR levels in a subset of cases. Our findings indicate that PR functions as a molecular rheostat to control ERα chromatin binding and transcriptional activity, which has important implications for prognosis and therapeutic interventions.
Time-Resolved Fluorescence Anisotropy Of Membrane Probes: Rotations Gated By Packing Fluctuations (1988)

Fluorescence emission anisotropy is a well established tool for measuring order in lipid bilayers. Coronene, a fluorescent membrane probe, with a mean fluorescence lifetime greater than 200ns, is sensitive to lipid chain disordering events that occur well after the decay of most other fluorescent probes. Further, its D6h planar symmetry provides exclusive detection of out-of-plane rotations. We have previously employed a compartmentalized gel-fluid equilibrium model to explain the time course of polarization for coronene in dimyristoylphosphatidylcholine (DMPC) and dipalmitoylphosphatidylcholine (DPPC) unilamellar vesicles (ULVs). We present here a more appropriate and complete model derived from Landau phase transition theory. A &apos;gating factor&apos; is employed, which defines the number of lipid chains close to a coronene molecule which must disorder to allow the rotation of coronene. This model predicts a distribution of rotational correlation times (0i) that change with temperature. Our results indicate excellent agreement between theoretical anisotropy decays and data taken for coronene labelled DPPC large unilamellar vesicles (LUVs) measured at several temperatures up to the lipid melt transition temperature (Tc). The model can account for depolarization both at long times and in the first few nanoseconds of decay.
Relationship between structure and biochemical phenotype of lecithin:cholesterol acyltransferase (LCAT) mutants causing fish-eye disease (2000)

In order to test the hypothesis that fish-eye disease (FED) is due to a deficient activation of lecithin:cholesterol acyltransferase (LCAT) by its co-factor apolipoprotein (apo) A-I, we overexpressed the natural mutants T123I, N131D, N391S, and other engineered mutants in Cos-1 cells. Esterase activity was measured on a monomeric phospholipid enelogue, phospholipase A(2) activity was measured on reconstituted high density lipoprotein (HDL), and acyltransferase activity was measured both on rHDL and on low density lipoprotein (LDL). The natural FED mutants have decreased phospholipase A(2) activity on rHDL, which accounts for the decreased acyltransferase activity previously reported. All mutants engineered at positions 131 and 391 had decreased esterase activity on a monomeric substrate and decreased acyltransferase activity on LDL. In contrast, mutations at position 123 preserved these activities and specifically decreased phospholipase A(2) and acyltransferase activites on rHDL. Mutations of hydrophilic residues in amphipathic helices alpha 3;-4 and alpha His to an alanine did not affect the mutants' activity on rHDL. Based upon the 3D model built for human LCAT, we designed a new mutant F382A, which had a biochemical phenotype similar to the natural T123I FED mutant. These data suggest that residues T123 and F382, located N-terminal of helices alpha 3-4 and alpha His, contribute specifically to the interaction of LCAT with HDL and possibly with its co-factor apoA-I. Residues N131 and N391 seem critical for the optimal orientation of the two amphipathic helices necessary for the recognition of a lipoprotein substrate by the enzyme.
Helicobacter pylori gastritis mimicking gastric carcinoma at CT evaluation. (1991)

The abdominal computed tomographic (CT) scans from 61 patients with biopsy-proved Helicobacter (formerly Campylobacter) pylori gastritis were retrospectively reviewed. The CT scans were interpreted on the basis of the original report of the findings at CT examination and without knowledge of the results of biopsy. Of 19 patients (31%) with gastric abnormalities at CT, 14 (74%) had inflammatory changes initially reported as suspicious for gastric malignancy; malignancy was entertained as the primary diagnosis in four of those patients. In five of the 19 abnormal cases (26%), the diagnosis with CT was gastritis. The two major patterns of severe H pylori infection identified were (a) circumferential antral wall thickening and (b) thickening of the posterior gastric wall along the greater curvature, with or without evidence of ulceration. Thickening averaged 1.5-2.0 cm in cases suspicious for malignancy. The majority of abnormalities involved the gastric antrum (68%). No cases demonstrated significant adenopathy, obliteration of fat planes, or invasion of adjacent organs.
The detection of left ventricular scar by delayed enhancement-CMR in non-ischemic cardiomyopathy is a stronger predictor of cardiovascular events than left ventricular ejection fraction (2013)

Background Left ventricular ejection fraction (LVEF) is a strong predictor of subsequent cardiovascular events in patients with ischemic and non-ischemic cardiomyopathy. CMR is an excellent technique for assessment of LVEF as well as for the detection of myocardial scar. We sought to evaluate if the presence of myocardial scarring in nonischemic cardiomyopathy could be an important predictor of cardiovascular events. Methods Inclusion criteria were absence of coronary artery disease, a diagnosis of cardiomyopathy and an LVEF ≤ 45%. Patients with a diagnosis of infiltrative disorders, hypertrophic cardiomyopathy, or tachycardia-induced cardiomyopathy were excluded. A total of 132 patients (with greater than 12 months follow up) were analyzed. Imaging was performed on a 1.5 Tesla Avanto, or 3.0 Tesla Verio MRI scanner (Siemens Medical Solutions). Cine images were performed using a steady state free precession pulse sequence. Delayed enhancement (DE) CMR was performed 10 minutes after administration of 0.15 mmol/kg Gadopentetate Dimeglumine (Bayer HealthCare) with typical in-plane resolution 18 x 2.0 mm, slice thickness 6-7 mm. LV and RV volumes and EF were analyzed by manual planimetry of endocardial contours during end-diastole and end-systole. DE-CMR images were analyzed to identify hyperenhanced myocardium (> 2 SD of remote signal intensity). The primary outcome was a combination of hospitalization for heart failure, LV assist device (LVAD) implantation, cardiac transplant, or death. Adjusted Kaplan-Meier curves were constructed for groups with and without scar by CMR with p<0.05 considered significant. Multivariate logistic regression analysis was performed. Results Patient’s demographics are shown in table. All baseline demographic data were similar between patients with and without scar by CMR. The adjusted event-free survival rate was significantly lower for patients with scar compared to patients without scar by CMR at 2-years (p=0.03) (graph). Mean scar burden was 3 ± 8% of LV. On multivariable analysis, the presence of scar was an independent predictor of events, HR 2.5(CI: 0.98-6.38, p=0.04), but LVEF was not. Conclusions In non-ischemic cardiomyopathy the presence of LV scar measured by DE-CMR is a stronger predictor of cardiovascular events than LVEF.
In vitro Anti-inflammatory Effect of Carthamus lanatus L. (2003)

The anti-inflammatory activity of four total extracts, their fractions and two main constituents (alpha-bisabolol beta-D-fucopyranoside and luteolin 7-O-glucoside) of Carthamus lanatus L. aerial parts, were assessed in vitro by determining the inhibitory effects on induced human neutrophils. The dichloromethane extract and its water-alcoholic part exhibited the most significant inhibitory effects.
A fully on-chip throughput measurement system for multi-gigabits/s on-chip interconnects (2011)

On-chip test circuits are key components for testing of sophisticated System on Chips (SoCs). This paper presents a fully on-chip test system to characterize high-speed on-chip interconnects. It measures the maximum data-rate at which an on-chip interconnect scheme can work (throughput). The proposed system is based on signature analysis technique. The components of the proposed system are chosen such that it can handle Bit Error Rate (BER) of the order of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-8</sup> . The test system is designed and laid out in 180nm CMOS technology. It can characterize the interconnect operating at data rates as high as 1.66 Gbps even in the worst process corner. Simulations using the device parameters measured from a test chip made in the same technology indicate that the measurable throughput by the proposed test system is 1.85 Gbps for that run. Even in the presence of temperature variations, the proposed system can handle highest possible throughput of the interconnects.
Influence of space-time rainfall variability on urban runoff (2006)

In small urban catchments a very high space-time rainfall resolution is needed in order to obtain with sufficient accuracy the flash flood forecasting as well as the monitoring of sewer systems. The errors in hyetograph input due to different spatial resolution are amplified by hydrological losses and flow processes so that they may produce some relevant errors in runoff volumes and peak discharges. In this paper we deal with a field investigation, carried out during an eight-year period on an urban test catchment located in the outskirts of Rome. This watershed drains a residential area and for its geomorphological and environmental characteristics, it can represent a typical situation in the Italian urban context. To link the precipitation measurements to the discharge ones a rainfall-runoff model is calibrated by the use of data with high spatial and temporal resolution; the results are shown in the paper.