gebhart/patrepeval huggingface dataset:
Phase I pharmacokinetic and pharmacodynamic study of the inhibitor of activation of AKT (p-Akt), triciribine phosphate monohydrate (TCN-PM), in solid malignancies (2007)

B71 Background: AKT is an important signal transduction kinase that is frequently dysregulated, and occasionally mutated, in cancer cells. Triciribine phosphase monohydrate (TCN-PM) is a tricyclic nucleoside that inhibits the levels of phosphorylated AKT (p-Akt) and suppresses selectively the growth of tumors with hyperactivated pAkt. Methods: We conducted a phase I dose escalation study of TCN-PM administered intravenously weekly over one hour days 1, 8 and 15, with treatment cycles every 28 days, in adult subjects with advanced solid tumors refractory to standard therapy, whose tumors had been demonstrated to have high levels of p-Akt by immunohistochemistry (IHC). Tumor biopsies were obtained prior to initiation of therapy and on day +16, and assessed for the presence of p-Akt by IHC and Western blot analysis. Results: Thirteen subjects have enrolled to date (M:F 5:8, mean age 60 years, range 46-81): eight subjects are evaluable for radiopgraphic response (see table below). Conclusions: Toxicity has been modest at the doses evaluated to date: accrual is ongoing. Updated pharmacokinetic and pharmacodynamic data will be presented at the meeting.
Susceptibility of melanized and nonmelanized Cryptococcus neoformans to nitrogen- and oxygen-derived oxidants (1994)

Melanized Cryptococcus neoformans cells were less susceptible than nonmelanized cells to the fungicidal effects of nitrogen- and oxygen-derived oxidants. The results support the hypothesis that the phenoloxidase enzyme system contributes to virulence by protecting C. neoformans against nitrogen- and oxygen-derived oxidative antimicrobial molecules produced by immune effector cells.
IP Exchange: I'll Show You Mine if You Show Me Yours (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Determination of defocus values using ‘Fourier images’ for high resolution electron microscopy (1979)

SUMMARY The phenomenon of Fourier images is used to calibrate defocus steps of a high resolution transmission electron microscope. Results compare well with measurements from an optical diffractogram.
Defining the Role of Donor Lymphocyte Infusion in High-Risk Hematologic Malignancies (2021)

Article Tools REVIEW ARTICLES Immunotherapy for Hematologic Malignancies Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.20.01719 Journal of Clinical Oncology - published online before print January 12, 2021 PMID: 33434060 Defining the Role of Donor Lymphocyte Infusion in High-Risk Hematologic Malignancies Christoph Schmid , MD1xChristoph SchmidSearch for articles by this author; Jürgen Kuball , MD2xJürgen KuballSearch for articles by this author; and Gesine Bug , MD3xGesine BugSearch for articles by this author Show More 1Department of Hematology and Oncology, Augsburg University Hospital, Augsburg, Germany2Department of Hematology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands3Department of Medicine 2, Goethe University, Frankfurt am Main, Germany https://doi.org/10.1200/JCO.20.01719 First Page Full Text PDF Figures and Tables Supplements © 2021 by American Society of Clinical OncologyAUTHOR CONTRIBUTIONSConception and design: All authorsCollection and assembly of data: All authorsData analysis and interpretation: All authorsManuscript writing: All authorsFinal approval of manuscript: All authorsAccountable for all aspects of the work: All authorsAUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTERESTDefining the Role of Donor Lymphocyte Infusion in High-Risk Hematologic MalignanciesThe following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/authors/author-center.Open Payments is a public database containing information reported by companies about payments made to US-licensed physicians (Open Payments).Christoph SchmidConsulting or Advisory Role: Roche, Daiichi Sankyo, NovartisSpeakers' Bureau: Jazz PharmaceuticalsExpert Testimony: KiadisTravel, Accommodations, Expenses: Neovii BiotechJürgen KuballEmployment: GadetaStock and Other Ownership Interests: GadetaConsulting or Advisory Role: Gadeta, Novartis (Inst)Speakers' Bureau: Gadeta, Miltenyi BiotechResearch Funding: Gadeta, Miltenyi Biotec, NovartisPatents, Royalties, Other Intellectual Property: Multiple patents on gdTCR sequences isolation strategies and targets in combination with dTCR sequencesTravel, Accommodations, Expenses: Gadeta, Novartis, Miltenyi BiotecGesine BugHonoraria: Jazz Pharmaceuticals, CelgeneConsulting or Advisory Role: Hexal, Novartis, Pfizer, Eurocept, Gilead Sciences, CelgeneResearch Funding: Novartis (Inst)Travel, Accommodations, Expenses: Gilead Sciences, Sanofi, Celgene, Neovii BiotechNo other potential conflicts of interest were reported.
Supplementary Figure 4 from Universal Cancer Peptide-Based Therapeutic Vaccine Breaks Tolerance against Telomerase and Eradicates Established Tumor (2023)

&lt;p&gt;PDF file - 57K, UCPs mediated helper effect on CTLs in other models of vaccinations&lt;/p&gt;
User attention oriented augmented reality on documents with document dependent dynamic overlay (2013)

When we read a document (any kind of, scientific papers, novels, etc.), we often encounter a situation that the information from the reading document is too less to comprehend what the author(s) would like to convey. In this paper, we demonstrate how the combination of a wearable eye tracker, a see-through head-mounted display (HMD) and an image based document retrieval engine enhances people's reading experiences. By using our proposed system, the reader can get supportive information in the see-through HMD when he wants. A wearable eye tracker and a document retrieval engine are used to detect which line in the document the reader is reading. We propose a method to detect the reader's attention on a word in a reading document, in order to present information at a preferable moment. Furthermore, we also propose a method to project a point of the document to a point of the HMD screen, by calculating the pose of the reading document in the camera image. This projection enables the system to overlay the information dynamically in an augmented view on the reading line. The results from the user study and the experiments show the potential of the proposed system in a practical use case.
Data from Imaging Colon Cancer Response Following Treatment with AZD1152: A Preclinical Analysis of [<sup>18</sup>F]Fluoro-2-deoxyglucose and 3′-deoxy-3′-[<sup>18</sup>F]Fluorothymidine Imaging (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; To determine whether treatment response to the Aurora B kinase inhibitor, AZD1152, could be monitored early in the course of therapy by noninvasive [&lt;sup&gt;18&lt;/sup&gt;F]-labeled fluoro-2-deoxyglucose, [&lt;sup&gt;18&lt;/sup&gt;F]FDG, and/or 3′-deoxy-3′-[&lt;sup&gt;18&lt;/sup&gt;F]fluorothymidine, [&lt;sup&gt;18&lt;/sup&gt;F]FLT, PET imaging.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental design:&lt;/b&gt; AZD1152-treated and control HCT116 and SW620 xenograft-bearing animals were monitored for tumor size and by [&lt;sup&gt;18&lt;/sup&gt;F]FDG, and [&lt;sup&gt;18&lt;/sup&gt;F]FLT PET imaging. Additional studies assessed the endogenous and exogenous contributions of thymidine synthesis in the two cell lines.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Both xenografts showed a significant volume-reduction to AZD1152. In contrast, [&lt;sup&gt;18&lt;/sup&gt;F]FDG uptake did not demonstrate a treatment response. [&lt;sup&gt;18&lt;/sup&gt;F]FLT uptake decreased to less than 20% of control values in AZD1152-treated HCT116 xenografts, whereas [&lt;sup&gt;18&lt;/sup&gt;F]FLT uptake was near background levels in both treated and untreated SW620 xenografts. The EC&lt;sub&gt;50&lt;/sub&gt; for AZD1152-HQPA was approximately 10 nmol/L in both SW620 and HCT116 cells; in contrast, SW620 cells were much more sensitive to methotrexate (MTX) and 5-Fluorouracil (5FU) than HCT116 cells. Immunoblot analysis demonstrated marginally lower expression of thymidine kinase in SW620 compared with HCT116 cells. The aforementioned results suggest that SW620 xenografts have a higher dependency on the &lt;i&gt;de novo&lt;/i&gt; pathway of thymidine utilization than HCT116 xenografts.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; AZD1152 treatment showed antitumor efficacy in both colon cancer xenografts. Although [&lt;sup&gt;18&lt;/sup&gt;F]FDG PET was inadequate in monitoring treatment response, [&lt;sup&gt;18&lt;/sup&gt;F]FLT PET was very effective in monitoring response in HCT116 xenografts, but not in SW620 xenografts. These observations suggest that &lt;i&gt;de novo&lt;/i&gt; thymidine synthesis could be a limitation and confounding factor for [&lt;sup&gt;18&lt;/sup&gt;F]FLT PET imaging and quantification of tumor proliferation, and this may apply to some clinical studies as well. &lt;i&gt;Clin Cancer Res; 17(5); 1099–110. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Amyloid neurotoxicity is attenuated by metallothionein: dual mechanisms at work (2012)

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive loss of memory and cognition. One of the hallmarks of AD is the accumulation of beta-amyloid (Aβ). Although endoplasmic reticulum stress, mitochondrial dysfunction, and oxidative stress have been implicated in Aβ toxicity, the molecular mechanism(s) of Aβ-induced neurotoxicity are not fully understood. In this study, we present evidence that the glia-derived stress protein metallothionein (MT) attenuates Aβ-induced neurotoxicity by unique mechanisms. MT expression was increased in brain astrocytes of a NSE-APPsw transgenic mouse model of AD. Astrocyte-derived MT protected N2a neuroblastoma cells and primary cortical neurons against Aβ toxicity with concurrent reduction of reactive oxygen species levels. MT reversed Aβ-induced down-regulation of Bcl-2 and survival signaling in neuroblastoma cells. Moreover, MT inhibited Aβ-induced proinflammatory cytokine production from microglia. The neurotoxicity of Aβ-stimulated microglia was significantly attenuated by MT-I. The results indicate that MT released from reactive astrocytes may antagonize Aβ neurotoxicity by direct inhibition of Aβ neurotoxicity and indirect suppression of neurotoxic microglial activation. These findings broaden the understanding of neurotoxic mechanisms of Aβ and the crosstalk between Aβ and MT in AD.
Contact Resistance Characteristics of Butt-Weld Joints of (Nd,Ti)3Sn Superconducting Wires. (1995)

Applicability of resistance butt welding to (Nb, Ti)3Sn multifilamentary superconducting wires was studied in both single-and seven-strand conductors, and the dominant factors for the contact resistance of those joints were investigated. Superconducting joint characteristics were partially attained in the case of welding after reaction (react & weld) and that of reaction after welding (weld & react). For react & weld joints, damaging effects on the superconducting filaments in the welding process were dominant, while for weld & react joints the degree of filament-to-filament alignment was found to be the dominant factor. In the seven-strand conductor joint case, the degree of strand-to-strand alignment at the bonding interface was found to become the dominant factor.
Dual change-of-phase in forced flow on a finite wall, with application to SLSF safety analysis (1979)

An important study related to the safety analysis of Liquid Metal Fast Breeder Reactors (LMFBRs) is to understand the phenomena of molten fuel relocation and refreezing on the core cold structures following a hypothesized loss-of-flow accident (LOFA). An assessment of molten fuel containment capability for the Sodium Loop Safety Facility (SLSF) in-pile experiments following a postulated LOFA is presented, considering the conditions of molten fuel flow, simultaneous melting in the outer duct wall, and convective cooling at the outer surface of the wall due to sodium coolant bypass flow.
Towards thrombosis-targeted zeolitenanoparticles for laser-polarized129Xe MRI (2008)

The synthesis and functionalisation of zeolite nanoparticles designed for laser-polarized 129Xe NMR experiments in solution are described. These nanoparticles were functionalized by using original synthesis pathways through semicarbazide COCHO chemistry in order to ensure anchoring of a peptide for targeting biological receptors and attachment of PEG chains for in vivo experiments. Results demonstrated that accessibility of the dissolved noble gas to the micropores was maintained after functionalization. γ Scintigraphy with 111In linked to the zeolite particles has been investigated in order to follow the behaviour of the zeolite nanoparticles in mice. These preliminary 111In scintigraphy experiments showed the localization of the nanoparticles after injection in mice and their biodistribution, as a first proof-of-concept towards in vivo129Xe MRI.
Onion Price Prediction Based on Artificial Intelligence (2020)

India being a horticulture nation, its economy prevalently relies upon horticulture yield development and agroindustry items. Information Mining is a developing examination field in onion yield investigation. Yield forecast is a significant issue in horticultural. Any rancher is keen on knowing how a lot yield he is going to anticipate. Break down the different related properties like area, pH esteem from which alkalinity of the dirt is decided. Alongside it, level of supplements like Nitrogen (N), Phosphorous (P), and Potassium (K) Location is utilized along with the utilization of outsider applications like APIs for climate and temperature, sort of soil, supplement estimation of the dirt in that locale, measure of precipitation in the district, soil organization can be decided. Every one of these traits of information will be examined, train the information with different appropriate AI calculations for making a model. The framework accompanies a model to be exact what's more, exact in foreseeing onion yield and convey the end client with appropriate proposals about required manure proportion in light of barometrical and soil parameters of the land which improve to build the harvest yield and increment rancher income.
<title>New analytical applications with UV fiber bundles</title> (2001)

Due to UV-fiber improvements within the last years, silica- based fibers with small core diameters are available for usage in fiber-bundles extending the range of applications into the deep UV-region below 250 nm. The well-known cross- section converter can be modified for usage in a capillary- holder for capillary electrophoresis. Y-assemblies for DUV- applications are tested within the thin-layer chromatography, leading to an significant improvement of this `old' technique. So, the short processing time including the preparation and low cost are advantageous, in respect to other separation-techniques. In addition to the properties of the different Y-assemblies under test, the separation results of polyaromatic hydrocarbons with the proposed TLC-method will be shown.
Electronic Refrigeration at the Quantum Limit (2009)

We demonstrate quantum-limited electronic refrigeration of a metallic island in a low-temperature microcircuit. We show that matching the impedance of the circuit enables refrigeration at a distance, of about 50 microm in our case, through superconducting leads with a cooling power determined by the quantum of thermal conductance. In a reference sample with a mismatched circuit this effect is absent. Our results are consistent with the concept of electromagnetic heat transport. We observe and analyze the crossover between electromagnetic and quasiparticle heat flux in a superconductor.
Dynamic Magnetic Resonance Imaging of the Pharynx during Deglutition (2013)

Dynamic magnetic resonance imaging of the swallow sequence is both feasible and reliable and may eventually complement currently used diagnostic methods, as it adds substantive information.
Inhibitory effect of locally administered heparin on leukocyte rolling and chemoattractant‐induced firm adhesion in rat mesenteric venules in vivo (1997)

1. Anti-inflammatory actions of heparin and related glycosaminoglycans have been described in the literature. Here, we used intravital microscopy of the rat mesentery microcirculation to examine effects of locally administered heparin on leukocyte rolling and chemoattractant-induced firm adhesion. 2. It was found that topical application of heparin reduced N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced leukocyte adhesion. Notably, the inhibitory action of heparin was not dose-dependent, but rather a biphasic dose-response was found, i.e. low (2 and 20 iu ml(-1)) and high (1000 iu ml(-1)) concentrations of heparin significantly reduced adhesion, whereas an intermediate dose (200 iu ml(-1)) was less effective. 3. Heparin, 2 and 20 iu ml(-1), decreased rolling leukocyte flux, while having no effect on blood flow or total leukocyte flux. By contrast, heparin, 200 and 1000 iu ml(-1), increased total leukocyte flux in parallel with a rise in volume blood flow resulting in recovery of the rolling leukocyte flux at these doses. Thus, the biphasic inhibitory action of heparin on fMLP-induced firm adhesion could in part be attributed to changes in leukocyte delivery (i.e. blood flow) and rolling leukocyte flux induced by heparin. 4. When compensating for the influence of different rolling levels on fMLP-evoked adhesion, a dose-related inhibitory effect of heparin on the firm adhesive response per se was revealed. Similar results were obtained in a static adhesion assay in vitro where heparin 200 and 1000 iu ml(-1) (but not 2 and 20 iu ml(-1)) significantly inhibited fMLP-induced leukocyte adhesion in the absence of any modulatory influence on changes in rolling. 5. Our data show that locally administered heparin inhibits leukocyte rolling as well as chemoattractant-induced firm adhesion in vivo which thus may contribute to the postulated anti-inflammatory activity of this compound. However, because of interference with several microvascular functions, strict dose-dependent responses to heparin treatment were not found, which illustrates the complex interplay between local blood flow, leukocyte rolling and chemoattractant-induced adhesion as determinants of leukocyte recruitment to tissues in inflammation.
Fabrication of Molecular Nanotemplates in Self‐Assembled Monolayers by Extreme‐Ultraviolet‐Induced Chemical Lithography (2007)

Extreme-UV interference lithography (EUV-IL) is applied to create chemical nanopatterns in self-assembled monolayers (SAMs) of 4'-nitro-1,1'-biphenyl-4-thiol (NBPT) on gold. X-ray photoelectron spectroscopy shows that EUV irradiation induces both the conversion of the terminal nitro groups of NBPT into amino groups and the lateral crosslinking of the underlying aromatic cores. Large-area ( approximately 2 mm(2)) nitro/amino chemical patterns with periods ranging from 2000 nm to 60 nm can be generated. Regions of pristine NBPT on the exposed samples are exchanged with protein-resistant thiol SAMs of polyethyleneglycol, resulting in the formation of molecular nanotemplates, which can serve as the basis of complex biomimetic surfaces.
Microsomal glutathione S-transferase is the predominant leukotriene C4 binding site in cellular membranes. (1994)

Dimethyl sulfoxide-differentiated U937 (dU937) cells express high affinity G-protein-coupled receptors for leukotriene (LT)D4 and LTB4 and, as described here, specific binding sites for LTC4. The specific binding of [3H]LTC4 was of low affinity (KD = 26 nM) and high abundance (Bmax = 33 pmol/mg of protein), as compared to LTD4 and LTB4 receptors. In addition, although [3H]LTC4 specific binding was enhanced by divalent cations, it was not inhibited by nonhydrolyzable GTP analogs. [3H]LTC4 specific binding to dU937 cell membranes does not have, therefore, the characteristics of binding to a G-protein-coupled receptor. Competition for [3H]LTC4 specific binding to dU937 cell membranes by leukotrienes and related analogs, including N-methylated LTC4, as well as glutathione, suggested a dependence on the presence of an arachidonic acid backbone, although varying degrees of saturation were well tolerated, and that the glutathione moiety of LTC4 in particular was important in determining affinity. The possibility that [3H]LTC4 specific binding was to a member of the glutathione S-transferase (GST) family of enzymes, such as LTC4 synthase, cytosolic GST, or microsomal GST, was therefore investigated. [3H]LTC4 specific binding sites could be separated from LTC4 synthase and cytosolic GSTs by differential detergent solubilization, but cofractionated with microsomal GST during solubilization and subsequent anion exchange chromatography. In membranes that were depleted of LTC4 synthase and cytosolic GSTs, 125I-azido-LTC4 (a photoaffinity probe based on LTC4) specifically photolabeled in a cation-dependent manner a 17-kDa polypeptide that was comparable in mass to the microsomal GST polypeptide. Furthermore, [3H]LTC4 bound specifically to purified human microsomal GST with the same characteristics as to the endogenous dU937-cell membrane specific binding sites. The principal [3H]LTC4 specific binding site present in dU937 cells, therefore, is not a G-protein-coupled receptor, LTC4 synthase, or cytosolic GSTs, but is microsomal GST. Finally, the 1:3 stoichiometry of [3H]LTC4 specific binding to purified microsomal GST is consistent with the enzyme functioning as a homotrimer.
Pulling by Pushing, Slip With Infinite Friction, and Perfectly Rough Surfaces (1995)

When one rigid object (the pusher) pushes another (the slider) across a horizontal support plane, Coulomb's law of friction admits some surprising phenomena. First, it is possible to move the slider by moving the pusher away from the slider: pulling. Second, even with an infinite coefficient of friction, it is possible to obtain slip between the two objects as the pusher moves into the slider. This contradicts the common conception that infinite friction always prevents slip. The per fectly rough contact of classical mechanics is not realized by an infinite coefficient of friction. This article shows examples of the phenomena with both quasistatic and dynamic analy ses.
Towards a Queueing-Based Framework for In-Network Function Computation (2011)

We seek to develop network algorithms for function computation in sensor networks. Specifically, we want dynamic joint aggregation, routing, and scheduling algorithms that have analytically provable performance benefits due to in-network computation as compared to simple data forwarding. To this end, we define a class of functions, the Fully-Multiplexible functions, which includes several functions such as parity, MAX, and k th -order statistics. For such functions we exactly characterize the maximum achievable refresh rate of the network in terms of an underlying graph primitive, the min-mincut. In acyclic wireline networks, we show that the maximum refresh rate is achievable by a simple algorithm that is dynamic, distributed, and only dependent on local information. In the case of wireless networks, we provide a MaxWeight-like algorithm with dynamic flow splitting, which is shown to be throughput-optimal.