gebhart/patrepeval huggingface dataset:
Tracking and modeling non-rigid objects with rank constraints (2005)

This paper presents a novel solution for flow-based tracking and 3D reconstruction of deforming objects in monocular image sequences. A non-rigid 3D object undergoing rotation and deformation can be effectively approximated using a linear combination of 3D basis shapes. This puts a bound on the rank of the tracking matrix. The rank constraint is used to achieve robust and precise low-level optical flow estimation without prior knowledge of the 3D shape of the object. The bound on the rank is also exploited to handle occlusion at the tracking level leading to the possibility of recovering the complete trajectories of occluded/disoccluded points. Following the same low-rank principle, the resulting flow matrix can be factored to get the 3D pose, configuration coefficients, and 3D basis shapes. The flow matrix is factored in an iterative manner, looping between solving for pose, configuration, and basis shapes. The flow-based tracking is applied to several video sequences and provides the input to the 3D non-rigid reconstruction task. Additional results on synthetic data and comparisons to ground truth complete the experiments.
Depth and durability of response to ibrutinib in CLL: 5-year follow-up of a phase 2 study (2018)

The safety and efficacy of ibrutinib (420 mg) in chronic lymphocytic leukemia (CLL) were evaluated in a phase 2 study; 51 patients had <i>TP53</i> aberration (TP53 cohort) and 35 were enrolled because of age 65 years or older (elderly cohort). Both cohorts included patients with treatment-naive (TN) and relapsed/refractory (RR) CLL. With the median follow-up of 4.8 years, 49 (57.0%) of 86 patients remain on study. Treatment was discontinued for progressive disease in 20 (23.3%) patients and for adverse events in 5 (5.8%). Atrial fibrillation occurred in 18 (20.9%) patients for a rate of 6.4 per 100 patient-years. No serious bleeding occurred. The overall response rate at 6 months, the primary study endpoint, was 95.8% for the TP53 cohort (95% confidence interval, 85.7%-99.5%) and 93.9% for the elderly cohort (95% confidence interval, 79.8%-99.3%). Depth of response improved with time: at best response, 14 (29.2%) of 48 patients in the TP53 cohort and 9 (27.3%) of 33 in the elderly cohort achieved a complete response. Median minimal residual disease (MRD) in peripheral blood was 3.8 × 10<sup>-2</sup> at 4 years, with MRD-negative (<10<sup>-4</sup>) remissions in 5 (10.2%) patients. In the TP53 cohort, the estimated 5-year progression-free survival (PFS) was 74.4% in TN-CLL compared with 19.4% in RR-CLL (<i>P</i> = .0002), and overall survival (OS) was 85.3% vs 53.7%, respectively (<i>P</i> = .023). In the elderly cohort, the estimated 5-year PFS and OS in RR-CLL were 64.8% and 71.6%, respectively, and no event occurred in TN-CLL. Long-term administration of ibrutinib was well tolerated and provided durable disease control for most patients. This trial was registered at www.clinicaltrials.gov as #NCT01500733.
Special Section on Electrical Contacts (2017)

Welcome to the Special Topics Section dedicated to the 2015 Holm Conference on Electrical Contacts. This Special Section contains six high-quality papers that comprehensively describe the state of the art and potential future directions for topics of great interest to our readers. The Editor-in-Chief (EIC), in consultation with the other EICs, Associate Editors (AEs), and domain experts, selects the topics for the Special Sections, and a Guest Editor or AE (GE/AE) who is a leading expert in the technical area then directs the solicitation and peer review of the papers. In cases where the GE/AE is also an author, the EIC is responsible for the peer review to avoid any real or perceived conflicts of interest.
ChemInform Abstract: PREPARATION OF ORGANOIMIDO AND μ‐DINITROGEN COMPLEXES OF TANTALUM AND NIOBIUM FROM NEOPENTYLIDENE COMPLEXES (1982)

Abstract Die Komplexe (I) reagieren mit den Imiden (II) neben quantitativer Bildung von tBuCH=CHPh zu den Organoimidokomplexen (III), in denen die THF‐Liganden durch Phosphine austauschbar sind, wie die Bildung des cis,mer‐Derivates (IV) demonstriert.
Synthesis of Glyceroyl β-N-Acetyllactosaminide and Its Derivatives through a Condensation Reaction by Cellulase (2003)

A condensation reaction between N-acetyllactosamine and glycerol was directly catalyzed by using a commercially available cellulase preparation from Trichoderma reesei. 1-O-beta-N-Acetyllactosaminyl-(R, S)-glycerols (1) were readily synthesized in a 5% yield based on the N-acetyllactosamine added and conveniently isolated by two-step column chromatographies. The use of a partially purified enzyme increased 2.3-fold the yield of 1, compared to that of the crude enzyme containing beta-D-galactosidase activity. When various alkanols (n:2-4) were used in the condensation reaction, the corresponding alkyl beta-N-acetyllactosaminides were obtained in yields of 0.3-1.1% of the desired compounds.
On comparative concepts and descriptive categories,suchas they are (2015)

The paper claims that the comparative concepts and descriptive categories of Haspelmath are not, pace Haspelmath, entities of a different type. The point is argued with a study of the properties of the English word such and of its counterparts in Dutch and Odia. The reason for choosing such is that it has proven difficult to categorize. It is argued that it is best treated as a category of its own, which one can call ‘similative’. It is more different from categories in its own language than from categories in other languages, and this similarity is what defines the comparative concept.
Observation of sizeable ω contribution to χc1(3872)→π+π−J/ψ decays (2023)

Resonant structures in the dipion mass spectrum from ${\ensuremath{\chi}}_{c1}(3872)\ensuremath{\rightarrow}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}J/\ensuremath{\psi}$ decays, produced via ${B}^{+}\ensuremath{\rightarrow}{K}^{+}{\ensuremath{\chi}}_{c1}(3872)$ decays, are analyzed using proton-proton collision data collected by the LHCb experiment, corresponding to an integrated luminosity of $9\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$. A sizeable contribution from the isospin conserving ${\ensuremath{\chi}}_{c1}(3872)\ensuremath{\rightarrow}\ensuremath{\omega}J/\ensuremath{\psi}$ decay is established for the first time, $(21.4\ifmmode\pm\else\textpm\fi{}2.3\ifmmode\pm\else\textpm\fi{}2.0)%$, with a significance of more than $7.1\ensuremath{\sigma}$. The amplitude of isospin violating decay, ${\ensuremath{\chi}}_{c1}(3872)\ensuremath{\rightarrow}{\ensuremath{\rho}}^{0}J/\ensuremath{\psi}$, relative to isospin conserving decay, ${\ensuremath{\chi}}_{c1}(3872)\ensuremath{\rightarrow}\ensuremath{\omega}J/\ensuremath{\psi}$, is properly determined, and it is a factor of 6 larger than expected for a pure charmonium state.
Cell-Based Therapy Restores Olfactory Function in an Inducible Model of Hyposmia (2019)

Stem cell-based therapies have been proposed as a strategy to replace damaged tissues, especially in the nervous system. A primary sensory modality, olfaction, is impaired in 12% of the US population, but lacks treatment options. We report here the development of a novel mouse model of inducible hyposmia and demonstrate that purified tissue-specific stem cells delivered intranasally engraft to produce olfactory neurons, achieving recovery of function. Adult mice were rendered hyposmic by conditional deletion of the ciliopathy-related IFT88 gene in the olfactory sensory neuron lineage and following experimentally induced olfactory injury, received either vehicle or stem cell infusion intranasally. Engraftment-derived olfactory neurons were identified histologically, and functional improvements were measured via electrophysiology and behavioral assay. We further explored mechanisms in culture that promote expansion of engraftment-competent adult olfactory basal progenitor cells. These findings provide a basis for translational research on propagating adult tissue-specific sensory progenitor cells and testing their therapeutic potential.
Modified Peptides as Potent Inhibitors of the Postsynaptic Density-95/N-Methyl-d-Aspartate Receptor Interaction (2008)

The protein-protein interaction between the NMDA receptor and its intracellular scaffolding protein, PSD-95, is a potential target for treatment of ischemic brain diseases. An undecapeptide corresponding to the C-terminal of the NMDA was used as a template for finding lead candidates for the inhibition of the PSD-95/NMDA receptor interaction. Initially, truncation and alanine scan studies were carried out, which resulted in a pentapeptide with wild-type affinity, as examined in a fluorescence polarization assay. Further examination was performed by systematic substitutions with natural and unnatural amino acids, which disclosed a tripeptide with micromolar affinity and N-methylated tetrapeptides with improved affinities. Molecular modeling studies guided further N-terminal modifications and introduction of a range of N-terminal substitutions dramatically improved affinity. The best compound, N-cyclohexylethyl-ETAV (56), demonstrated up to 19-fold lower K i value ( K i = 0.94 and 0.45 microM against PDZ1 and PDZ2 of PSD-95, respectively) compared to wild-type values, providing the most potent inhibitors of this interaction reported so far. These novel and potent inhibitors provide an important basis for development of small molecule inhibitors of the PSD-95/NMDA receptor interaction.
Measurement of geometrical parameters in cocontinuous polymer blends: 3D versus 2D image analysis (2010)

Formulae of stereology are used to estimate 3D geometrical parameters of cocontinuous structures measured from 2D micrographs of polymer blends. 3D images of symmetric and nonsymmetric polymer blends made of fluorescently labelled polystyrene and styrene-ran-acrylonitrile copolymer were obtained with laser scanning confocal microscopy. Geometrical parameters of the blend interface, specifically volume fraction, surface area per unit volume (S (V) ) and average of local mean curvature were measured directly from the 3D images and compared to the values estimated from analysis of a number of 2D slices combined with stereological relations. When the total length of phase boundary considered in the analysis of the 2D slices (L(Tot) ) was at least 6000 times bigger than the characteristic length of the microstructure (S(-1) (V) ), the standard deviation for all the parameters measured became negligible. However, considerable discrepancies between the average values computed from 3D and 2D images were observed for any value of L(Tot) . The mean curvature distribution was also measured from both the 3D images and the 2D slices. The distribution was estimated from the 2D slices but with a width about 2.4 times that of the true value obtained from the 3D images.
Finite Strain Elastostatics With Stiffening Materials: A Constrained Minimization Model (1997)

Finite strain elastostatics is expressed for general anisotropic, piecewise linear stiffening materials, in the form of a constrained minimization problem. The corresponding boundary value problem statement is identified with the associated necessary conditions. Total strain is represented as a superposition of variationally independent constituent fields. Net stress-strain properties in the model are implicit in terms of the parameters that define the constituents. The model accommodates specification of load fields as functions of a process parameter.
Inverter control during overload and following power interruption (2003)

A frequency control method is presented that interacts with a voltage-controlled current-regulated pulse-width modulation (CRPWM) inverter to provide operation during and after a momentary overload and reconnection to a de-energized rotating motor under load. This is accomplished without overcurrent trips, knowledge of motor parameters, or velocity feedback. In addition, a stability study of the synchronous voltage-controlled CRPWM inverter is performed that determines the effects of controller, motor, and load variations on the region of instability. Results reveal that the synchronous voltage-controlled CRPWM inverter and traditional open velocity loop PWM inverter have similar unstable regions with respect to operating frequency.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Physical constants (2006)

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Molecular genetics of X-linked mental retardation: a complex picture emerging (2001)

Mental retardation or intellectual disability is a heterogeneous group of disorders of the human brain affecting 2-3% of the general population. It is becoming evident that a large proportion of mental retardation is genetically determined, which means that it can be molecularly defined and thus precisely diagnosed. Building knowledge and understanding about molecular processes leading to 'malfunction of human brain' will clearly bring benefits to patient management, disease prevention and ultimately disease treatment and will also assist in tackling much harder questions of the molecular basis of human cognitive ability. In this review the current knowledge of the molecular genetics of X-chromosome-linked mental retardation and its nonspecific forms in particular is discussed, together with limitations affecting diagnosis and likely new approaches that need to be implemented.
Modular chip-integrated photonic control of artificial atoms in diamond waveguides (2023)

A central goal in creating long-distance quantum networks and distributed quantum computing is the development of interconnected and individually controlled qubit nodes. Atom-like emitters in diamond have emerged as a leading system for optically networked quantum memories, motivating the development of visible-spectrum, multi-channel photonic integrated circuit (PIC) systems for scalable atom control. However, it has remained an open challenge to realize optical programmability with a qubit layer that can achieve high optical detection probability over many optical channels. Here, we address this problem by introducing a modular architecture of piezoelectrically actuated atom-control PICs (APICs) and artificial atoms embedded in diamond nanostructures designed for high-efficiency free-space collection. The high-speed four-channel APIC is based on a splitting tree mesh with triple-phase shifter Mach–Zehnder interferometers. This design simultaneously achieves optically broadband operation at visible wavelengths, high-fidelity switching (&gt;40dB) at low voltages, submicrosecond modulation timescales (&gt;30MHz), and minimal channel-to-channel crosstalk for repeatable optical pulse carving. Via a reconfigurable free-space interconnect, we use the APIC to address single silicon vacancy color centers in individual diamond waveguides with inverse tapered couplers, achieving efficient single photon detection probabilities (∼15%) and second-order autocorrelation measurements g (2) (0)&lt;0.14 for all channels. The modularity of this distributed APIC–quantum memory system simplifies the quantum control problem, potentially enabling further scaling to thousands of channels.
Computing Environments for Data Analysis I. Introduction (1985)

This is the first in a series of papers on aspects of modern computing environments that are relevant to statistical data analysis. We argue that a network of graphics workstations is far superior to conventional batch or time-sharing computers as an environment for interactive data analysis. The first paper in the series provides a general introduction and motivation for more detailed considerations of hardware and software in subsequent parts.
Independent Component Analysis for Vision-inspired Classification of Retinal Images with Age-related Macular Degeneration (2008)

The purpose of this paper is to present a novel approach for extracting image-based features for classifying age-related macular degeneration (AMD) in digital retinal images. 100 retinal images were classified by an ophthalmologist into 12 categories based on the visual characteristics of the disease. Independent Component Analysis (ICA) was used to extract features at different spatial scales to be used as input to a classifier. The classification used a type of regression, partial least squares. In this experiment ICA replicated the ophthalmologist's visual classification by correctly assigning all 12 images from two of the classes.
Fabrication of high stabilized efficiency a-Si solar cells by using SiH/sub 2/Cl/sub 2/ addition (2002)

We have applied SiH/sub 2/Cl/sub 2/ addition together with H/sub 2/ dilution to a-Si:H films and solar cells fabricated by mercury-sensitized photo-CVD. It was observed by SIMS measurements that Cl was incorporated into a-Si:H films over 10/sup 18/ atom/cm/sup 3/, even at the flow rate ratio of 0.01(SiH/sub 2/Cl/sub 2/ to SiH/sub 4/). Furthermore, it was found that excess Cl incorporated in a-Si:H films had been removed by H/sub 2/ dilution. With H/sub 2/ dilution, we could control the excess acceptor states of a-Si:H films grown by SiH/sub 2/Cl/sub 2/ addition and when we applied them to the i-layer of a-Si solar cells, quantum efficiencies increased at all wavelength region and especially at middle wavelength region which is sensible to the electric field weakening of the i-layer by light induced degradation. As a result, we have achieved a high stabilized efficiency of 9.0% for an 1 cm/sup 2/ single-junction a-Si:H solar cell.
Pre-clinical studies and phase I clinical trial of the anti-CD22 immunotoxin CAT-3888 (BL22) for pediatric acute lymphoblastic leukemia (ALL) (2007)

9560 Background: ALL is the most common childhood malignancy. Although highly curable, therapy is associated with multiple toxicities and ALL remains the most frequent cause of pediatric cancer mortality. Most ALL is CD22+ and we evaluated the anti-CD22 immunotoxin RFB4(dsFv)-PE38 (BL22 or CAT-3888) in the treatment of pediatric ALL. Methods: In vitro cytotoxicity was assessed on blasts from 42 children with CD22+ ALL. In vivo studies were performed using a xenograft model (SCID mouse - EU1 human ALL cell line). A pediatric phase I trial of CAT-3888 was initiated. Results: CAT-3888 induced in vitro cytotoxicity against most ALL samples (median IC 50 9.8 ng/ml). A dose response was observed in murine xenografts with significant prolongation of leukemia free survival (p&lt;0.05). 18 subjects (15 ALL, 3 lymphoma; 3 - 22 years of age) were treated on a Phase I trial at doses of 10 - 40 mcg/kg QOD for 3 - 6 doses with cycles repeated every 21 - 28 days. Treatment was well tolerated and no dose limiting toxicity was seen. Pharmacokinetics were influenced by disease burden and T 1/2 showed an inverse relationship to marrow blasts (r 2 =0.5) consistent with rapid drug binding by CD22+ cells. All subjects were heavily pre-treated and had progressive high burden disease at the time of treatment. Transient clinical activity was observed in 16 of 18 subjects as evidenced by decreased peripheral blast count (8), decreased marrow infiltration (3), decreased extramedullary disease (2), increased platelet count (2), increased neutrophil count (1), increased reticulocyte count (1), improved PET scan (1), decreased tumor-associated pain (2), and/or peripheral blast count stabilization (3). A dose response was apparent with 4 of 9 (44%) achieving stable disease at or above doses of 30 mcg/kg. Conclusions: The majority of pediatric ALL blasts are highly sensitive in vitro to CAT-3888 at concentrations far below clinically achievable levels. CAT-3888 is well tolerated in pediatric patients and activity has been seen in most subjects treated on the phase I trial. CD22 represents a relevant target for pediatric ALL. A new higher affinity anti-CD22 immunotoxin (HA22 or CAT-8015) is in development. No significant financial relationships to disclose.
Design of a Hyper-Spectral Imaging System for Gross Pathology of Pigmented Skin Lesions (2021)

Pigmented skin lesions (PSL) are prevalent in Asian populations and their gross pathology remains a manual, tedious task. Hyper-spectral imaging (HSI) is a non-invasive non-ionizing acquisition technique, allowing malignant tissue to be identified by its spectral signature. We set up a hyper-spectral imaging (HSI) system targeting cancer margin detection of PSL. Because classification among PSL is achieved via comparison of spectral signatures, appropriate calibration is necessary to ensure sufficient data quality. We propose a strategy for system building, calibration and pre-processing, under the requirements of fast acquisition and wide field of view. Preliminary results show that the HSI-based system is able to effectively resolve reflectance signatures of ex-vivo tissue.Clinical Relevance-The imaging system proposed in this study can recover reflectance spectra from PSL during gross pathology, providing a wide imaging area.
Near-Contact Gas Damping and Dynamic Response of High-g MEMS Accelerometer Beams (2013)

This paper introduces and experimentally validates a new model for near-contact gas damping of microbeams. The model is formulated based on numerical simulations of rarefied gas dynamics using the Boltzmann Ellipsoidal Statistical Bhatnagar-Gross-Krook (ES-BGK) equation. The result is compared with existing models by simulating the motion of beams under high-g acceleration. To experimentally validate the damping models, single crystal silicon MEMS g-switches with cantilever microbeams of various lengths were utilized. The experimental measurements of beam dynamics under peak accelerations of approximately 50,000 g and acceleration ramp rates from 600 to 3,000 g/μs are compared with simulations. Additionally, the damping coefficients are extracted from existing vibrational mode data, and the resulting values are compared to the various models. The new near-contact model was found to predict contact and release times within a root-mean-square deviation from experiment below 9 and 7 for contact and release events, respectively. The damping values for the vibrational modes away from contact were predicted within 33% error, showing a more consistent predictive capability than provided by earlier models.
New hole-transporting amorphous molecular materials with high glass-transition temperatures for organic light-emitting diodes (2007)

The synthesis and properties of new hole-transporting amorphous molecular materials with high glass-transition temperatures are described. They include 4,4',4"-tris[9,9-dimethylfluoren-2-yl(phenyl)amino]- triphenyl-benzene (TFAPB), 4,4',4"-tris[9,9-dimethylfluoren-2-yl(4-methylphenyl)amino]triphenylbenzene (MTFATB), and 4,4',4"-tris[bis(9,9-dimethylfluoren-2-yl)amino]triphenyl-benzene (TBFAPB). It is shown that they function well as hole-transporting materials in thermally stable organic light-emitting diodes.