gebhart/patrepeval huggingface dataset:
High-purity single photon emitter in aluminum nitride photonic integrated circuit (2017)

Efficient, on-demand, and robust single photon emitters (SPEs) are important to a wide varity of applications in quantum information processing [1]. Over the past decade, color centers in solid-state systems have emerged as excellent SPEs [2] and have also been shown to provide optical access to internal spin states at room and cyogenic temperatures. Color centers in diamond [3] and silicon carbide [4] are among the most intensively studied SPEs. Recently, other cost-efficient wide-bandgap materials have become attractive as potential host materials. Theoretical calculations show that aluminum nitride (AlN) with a bandgap of 6.015 eV can serve as a stable environment for well isolated SPEs with optically accessible spin states [5].We report on a room-temperature quantum emitter that emits in the orange visible spectrum. The temperature induced phonon broadening of the 2ero phonon line at 2.08 eV is shown in Fig. 1(a). The SPEs are hosted by AlN thin-films (200 nm) on sapphire substrates. Annealing treatments enable the control of the emitters photostability and visibility.
ChemInform Abstract: 4‐((Carboxymethyl)oxy)‐ and 4‐((Carboxymethyl)amino)‐5,7‐ dichloroquinoline‐2‐carboxylic Acid: New Antagonists of the Strychnine‐ Insensitive Glycine Binding Site on the N‐Methyl‐D‐aspartate Receptor Complex. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Aryl and Heteroaryl Acyl Sulfamide Synthesis via Microwave‐Assisted Palladium‐Catalyzed Carbonylation. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Figure Legends from Cyclooxygenase-2 Inhibition Suppresses α<sub>v</sub>β<sub>6</sub> Integrin–Dependent Oral Squamous Carcinoma Invasion (2023)

Supplementary Figure Legends from Cyclooxygenase-2 Inhibition Suppresses α&lt;sub&gt;v&lt;/sub&gt;β&lt;sub&gt;6&lt;/sub&gt; Integrin–Dependent Oral Squamous Carcinoma Invasion
Distributed space–time and space–frequency coding (2008)

The main drawback of the multi-node decode-and-forward (DF) protocol and the multinode amplify-and-forward (AF) protocol, presented in Chapter 5, is the loss in the data rate as the number of relay nodes increases. The use of orthogonal sub channels for the relay node transmissions, either through TDMA or FDMA, results in a high loss of the system spectral efficiency. This leads to the use of what is known as distributed space–time coding (DSTC) and distributed space–frequency coding (DSFC), where relay nodes are allowed to simultaneously transmit over the same channel by emulating a space–time or a space–frequency code. The term distributed comes from the fact that the virtual multi-antenna transmitter is distributed between randomly located relay nodes. Employing DSTCs or DSFCs reduces the data rate loss due to relay nodes transmissions without sacrificing the system diversity order, as will be seen in this chapter.
Candida: What Should Clinicians and Scientists Be Talking About? (2014)

Candida is often described as an “opportunistic” pathogen. While Candida has clearly coevolved with humans to persist on the mucosa and skin, disseminated candidiasis has only become common within the past 50 years, when advances in medical technology rendered patients susceptible to this disease. Animal models available to date have been extremely helpful and have generated fundamental knowledge regarding pathogenesis and treatment of disseminated candidiasis. However, for development of optimal prophylactic or therapeutic strategies, it will be necessary to increasingly study the pathogenesis and immunology of Candida infections directly in humans. The simplest conceptual means to improve morbidity and mortality from disseminated candidiasis is to create more effective antifungal therapies. Given the considerable morbidity and mortality of disseminated candidiasis even with treatment, deployment of effective prophylactic strategies is highly desirable. Simply administering Candida into the bloodstream does not necessarily result in established infection, because the reticuloendothelial system and neutrophils in normal mammalian hosts are so efficient at cleaning the blood of fungal burden. Indeed, elegant clinical studies have confirmed the role of pattern recognition receptor polymorphisms in predisposing to mucosal candidiasis or candidal colonization. The transmission dynamics, epidemiology, and ecology of Candida in the nosocomial setting are understudied. New clinical strategies, such as de-escalation therapy, infection control strategies, are critically needed to improve our prevention and treatment of Candida infections.
Prospects for frequency comparison of Sr and Hg optical lattice clocks toward 10<sup>&#x2212;18</sup> uncertainties (2012)

We are developing optical lattice clocks with a scope of attaining 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-18</sup> fractional uncertainty. Cryogenic silicon cavity targeting 2×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-17</sup> stability at 1s, will allow full utilization of the potential stability of optical lattice clocks. In order to reduce the blackbody radiation shift, which is the most serious source of uncertainties, Sr clocks in cryogenic environment and Hg clocks are underdevelopment. We discuss prospects for clock comparison, no dead time operation of the clocks and fiber link of the clocks between Riken and the University of Tokyo.
Information processing using stable and unstable oscillations: a tutorial (2002)

We review some principles for information storage and processing, based on oscillations in dynamical systems. Oscillations and chaos are present in both biological and artificial neurons. A single biological neuron has an oscillatory dynamics, and can generate chaos. At a macroscopic level however, chaos is not created by the dynamics of individual neurons, but by the interaction of large groups of neurons. These macroscopic oscillations are measured by EEG recordings that indicate the presence of chaotic attractors in the brain. Also in the visual cortex, neurons have been found to oscillate in a coherent way depending on the global stimulus. On the other hand, as recurrent artificial neural networks are non linear dynamical systems, it is possible to get different behaviours by adjusting their parameters: convergence toward equilibrium points, toward periodic solutions or chaotic trajectories. In this case, the study of oscillations is more a scientific activity than a goal for storing and processing information. In this paper, however, we explore the possibilities to make use of chaos for information storage.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Fast de-streaking method using plain neural network (2017)

Radon transform fundamentally underlies reconstructions from computed tomography. Radon transform results in a sinogram where each coefficient represents the integral of the image on one line from one angle. From a full Radon sinogram, one can rebuild the initial image with Filtered Back Projection (FBP) algorithm. However, when information from some angles are missing, streaks appear on the output image using such method. In this work, we propose a method that works exclusively on the image domain: a de-streaker based on plain neural network. The objective is not to replace reconstruction methods, but to offer a fast post-processing that reduces artifacts from the output image, particularly when sinogram is unavailable.
Synthesis of Cyclopropane Isosteres of the Antiepilepsy Drug Vigabatrin and Evaluation of their Inhibition of GABA Aminotransferase (2004)

The antiepilepsy drug vigabatrin (1; 4-aminohex-5-enoic acid; gamma-vinyl GABA) is a mechanism-based inactivator of the pyridoxal 5'-phosphate (PLP)-dependent enzyme gamma-aminobutyric acid aminotransferase (GABA-AT). Inactivation has been shown to proceed by two divergent mechanisms (Nanavati, S. M. and Silverman, R. B. (1991) J. Am. Chem. Soc. 113, 9341-9349), a Michael addition pathway (Scheme 2, pathway a) and an enamine pathway (Scheme 2, pathway b). Analogs of vigabatrin with a cyclopropyl or cyanocyclopropyl functionality in place of the vinyl group (2-5) were synthesized as potential inactivators of GABA-AT that can inactivate the enzyme only through a Michael addition pathway, but they were found to be only weak inhibitors of the enzyme.
Data from Cancer-Testis Antigens: Expression and Correlation with Survival in Human Urothelial Carcinoma (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Vaccination against human cancer is a promising therapeutic approach but the optimal antigen or antigens remain undefined. Cancer-testis antigens (CTA), a family of tumor-associated antigens, have both potent immunogenicity and restricted expression patterns in normal adult tissues, highly desirable characteristics for targets of anticancer vaccines. These antigens were evaluated for both the degree of expression and prognostic value in cancer of the urothelium.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; The expression patterns of nine CTAs (NY-ESO-1, LAGE-1, MAGE-A1, MAGE-A3, MAGE-A4, MAGE-A10, CT7, CT10, and GAGE) were examined by immunohistochemistry and reverse transcription-PCR in a panel of high-grade urothelial carcinomas of the urinary bladder. Also assessed were correlations between the expression of CTAs by immunohistochemistry and both disease-free and overall survival.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; At least one CTA was expressed in 77% of samples and 61% of these tumors expressed more than one CTA. Additionally, patients with CT10-positive tumors had an improved disease-free survival (&lt;i&gt;P&lt;/i&gt; = 0.008) and overall survival (&lt;i&gt;P&lt;/i&gt; = 0.037) compared with patients with CT10-negative tumors.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; These findings establish CTAs as potential prognostic markers and as target candidates for vaccine development for patients with urothelial carcinoma.&lt;/p&gt;&lt;/div&gt;
Are Viscoelastic Tests Clinically Useful to Identify Platelet-Dependent Bleeding in High-Risk Cardiac Surgery Patients? (2022)

QUANTRA PCS, ROTEM A10 PC, and Multiplate ADPtest showed a significant decrease after CPB, whereas ROTEM PC and Multiplate TRAPtest did not. Major bleeding was predicted with a moderate to good discrimination by the post-CPB viscoelastic tests (PCS, PC, and A10 PC).
Expression of an estrogen-regulated variant transcript of the peroxisomal branched chain fatty acid oxidase ACOX2 in breast carcinomas (2015)

ACOX2-i9 is specifically enriched in ER+ breast cancers where expression of the variant is associated with improved outcome. These data identify variant ACOX2 as a potential novel therapeutic biomarker in ER+ breast tumors.
Supramolecular Liquid-Crystalline Complexes Exhibiting Room-Temperature Mesophases and Electrooptic Effects. Hydrogen-Bonded Mesogens Derived from Alkylpyridines and Benzoic Acids (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSupramolecular Liquid-Crystalline Complexes Exhibiting Room-Temperature Mesophases and Electrooptic Effects. Hydrogen-Bonded Mesogens Derived from Alkylpyridines and Benzoic AcidsTakashi Kato, Mitsuo Fukumasa, and Jean M. J. FrechetCite this: Chem. Mater. 1995, 7, 2, 368–372Publication Date (Print):February 1, 1995Publication History Published online1 May 2002Published inissue 1 February 1995https://pubs.acs.org/doi/10.1021/cm00050a021https://doi.org/10.1021/cm00050a021research-articleACS PublicationsRequest reuse permissionsArticle Views475Altmetric-Citations115LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Increased .GAMMA.-aminobutyrate aminotransferase activity in brain of patients with Alzheimer's disease. (1990)

In order to search for more proximal factors in the pathogenesis of Alzheimer's disease, we studied the activities of various enzyme in the brains of patients, as well as control cases, by postmortem autopsy. In addition to the findings already known, such as the increase in prolyl endopeptidase (post-proline cleaving enzyme, PPCE) activity and the decrease in kallikrein activity, we found, anew, an increase in aminobutyrate aminotransferase (GABA-T) activity in the Alzheimer brain. This may be an important impetus for the reduction of gamma-aminobutyric acid (GABA) in the brain, one of the neurotransmitters. It has to be determined whether the former two abnormalities offer a background for such an abnormality of the neurotransmitter.
Mitoxantrone and melphalan as a conditioning regimen for autologous peripheral blood stem cell transplantation in adults with acute myelogenous leukemia (2006)

A variety of conditioning regimens are used for autologous hematopoietic stem cell transplantation in patients with acute myelogenous leukemia (AML). High dose mitoxantrone and melphalan (Mito/Mel) has been reported as an effective and well-tolerated regimen for autologous peripheral blood stem cell transplantation (APBSCT) in patients with lymphoma. We review our experience with Mito/Mel as a conditioning regimen in 18 adult patients (12 female, 6 male) with intermediate or high risk AML who underwent APBSCT. All patients received anthracycline based induction and consolidation chemotherapy prior to APBSCT. At the time of transplantation, 16 patients were in first complete remission (CR) and 2 patients were in second CR. Median age at the time of APBSCT was 51 years (range 19–70). All patients received a conditioning regimen consisting of mitoxantrone 60 mg/m2 IV on day −4 and melphalan 180 mg/m2 IV on day −1, followed by infusion of autologous peripheral blood stem cells on day 0. Rapid hematologic recovery was observed in most patients, with values of ANC >500 and platelet >20,000 being reached at 13 and 16 days, respectively. Cardiac toxicity was monitored by echocardiogram. All patients demonstrated a normal left ventricular ejection fraction (LVEF) prior to receiving the conditioning regimen. There were no deaths attributable to heart failure. A significant decline in LVEF developed in only one patient who was over age 60 with underlying diabetes and hypertension. Ninety-four percent of patients survived the first 100 days following transplant. To date, 7 patients are alive and in remission at 2 to 7 years since disease onset, with no patients lost to follow-up. The 3-year failure-free and overall survival are 44% and 55%, respectively. We conclude that high dose mitoxantrone and melphalan is an effective and easily administered conditioning regimen with a low risk of significant cardiac toxicity despite prior treatment with anthracycline based chemotherapy, and thus is a safe regimen for APBSCT in adults with AML.
Catalytic Reduction of Dinitrogen to Ammonia at Well‐Defined Single Metal Sites (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Matrix Modulation: Low SNR Aspects (2003)

This chapter contains sections titled: Linear Matrix Modulation Examples Heuristic Design Rules at Low SNR Matched Filtering and Maximum Likelihood Metric Mutual Information Expansion around Diagonal Dominance Performance of Examples Summary
In vitro evaluation of the anti-bacterial effect of two preparations of platelet rich plasma compared with cefazolin and whole blood (2014)

The application of PRPLP and PRPHP showed a significant decrease in bacterial growth after 8 hours for S. aureus, S. epi, MRSA and P. acnes compared to the whole blood control group. S.epi, MRSA, and P. acnes also showed a significant decrease in bacterial growth after 24 hours. Despite differences in platelet concentration and WBC concentration, no difference in antibacterial activity was seen between the two preparations.
Interleukin‐10‐secreting T cells define a suppressive subset within the HIV‐1‐specific T‐cell population (2009)

Recent studies have indicated that Treg contribute to the HIV type 1 (HIV-1)-related immune pathogenesis. However, it is not clear whether T cells with suppressive properties reside within the HIV-1-specific T-cell population. Here, PBMC from HIV-1-infected individuals were stimulated with a 15-mer Gag peptide pool, and HIV-1-specific T cells were enriched by virtue of their secretion of IL-10 or IFN-gamma using immunomagnetic cell-sorting. Neither the IL-10-secreting cells nor the IFN-gamma-secreting cells expressed the Treg marker FOXP3, yet the IL-10-secreting cells potently suppressed anti-CD3/CD28-induced CD4(+) as well as CD8(+) T-cell proliferative responses. As shown by intracellular cytokine staining, IL-10- and IFN-gamma-producing T cells represent distinct subsets of the HIV-1-specific T cells. Our data collectively suggest that functionally defined HIV-1-specific T-cell subsets harbor potent immunoregulatory properties that may contribute to HIV-1-associated T-cell dysfunction.
Tissue engineering based on muscle‐derived stem cells: Potential applications for tissue regeneration (2011)

Members of my laboratory have isolated various populations of myogenic cells from the postnatal skeletal muscle of normal mice on the basis of the cells' adhesion characteristics, proliferation behavior, and myogenic and stem cell marker expression profiles. Although most of these cell populations have displayed characteristics similar to those of satellite cells, we also have identified a unique population of muscle-derived stem cells (MDSCs). MDSCs exhibit long-term proliferation and high self-renewal rates and can differentiate toward various lineages, both in vitro and in vivo. The transplantation of MDSCs, in contrast to that of other myogenic cells, has improved the efficiency of dystrophic muscle regeneration and the delivery of dystrophin to dystrophic muscle. The ability of MDSCs to proliferate in vivo for an extended period of time, combined with their capacity to exhibit self-renewal, multipotent differentiation, and transplantation. Recent studies performed by members of my laboratory have shown that transplantation of female MDSCs (F-FMSCs) rather than male MDSCs (M-MDSCs) significantly improves skeletal muscle regeneration despite the similar myogenic and stem cell marker expression by both cell types. I will explain the increased muscle regeneration efficiency exhibited by F-MDSCs. My presentation will also address the influence of environmental cues within dystrophic or injured skeletal muscle on the differentiation of MDSCs into fibrotic cells. I will discuss potential strategies by which to prevent scar tissue formation within injured muscle by blocking TGF-β1 activity. I then will discuss the use of MDSCs in gene therapy and tissue engineering applications designed to improve bone and articular cartilage healing through the genetic modification of MDSCs to express osteogenic proteins (BMP2 and −4) and the angiogenic factor VEGF. I will also outline in my presentation new results obtained with human muscle derived stem cells, which we believe will open new avenues by which researchers could use muscle stem cell-based gene therapy and tissue engineering to improve tissue regeneration.
Through silicon vias technology for CMOS image sensors packaging (2008)

In this paper a low temperature 'via-last' technology will be presented. This technology has been especially developed for CMOS image sensors wafer level packaging. The design rules of the vias will be briefly described and then, the steps of the technology will be presented : glass wafer carrier bonding onto the silicon substrate, silicon thinning and backside technology including specific steps like double side lithography, silicon deep etching, silicon side wall insulation, vias metallization and final bumping. Morphological and electrical characterizations of the vias-last technology will be showed and discussed. Finally, a picture obtained with the TSV CMOS Image Sensor (TSV CIS) will be presented.
Structure—Activity Relationships of 2‐(Benzothiazolylthio)acetamide Class of CCR3 Selective Antagonist. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
T-cell and Transcriptomic Responses to Prime-boost Strategies of 3 HIV Vaccines(MVA HIV-B; LIPO-5; GTU-MultiHIV B)-ANRS/INSERM VRI01 Trial (2018)

International audience
Abstract 9696: Long-Term Outcomes With Abandoning versus Extracting Sterile Leads: A 10-Year Population-Based Study (2022)

Background: Long-term outcomes of lead management strategies of lead abandonment (LA) or transvenous lead extraction (TLE) during cardiac implantable electronic devices (CIED) procedures requiring lead addition or replacement remain unclear. Hypothesis: We hypothesized that there is no difference in long-term (10-year) outcomes of LA versus TLE during CIED procedures requiring lead addition. Methods: We performed a retrospective cohort study of a population residing in seven adjacent counties of southeastern Minnesota with follow-up at the Mayo Clinic and its health systems. Patients who underwent LA or TLE for sterile leads from January 1, 2000, to January 1, 2011, and had follow-up for at least 10-years or until their death were included. Outcomes were identified through a detailed chart review of the electronic health record from within the Mayo Clinic system. Results: A total of 172 patients were included in the study with 153 patients who underwent LA and 19 who underwent TLE for sterile leads. In long-term follow-up, indications for subsequent lead extraction arose in 9.1% (n=14) of patients with initial LA and 5.3% (n=1) in patients with initial TLE, after an average of 7-years. Moreover, out of 14 patients, who required secondary extraction in the LA cohort, 28.6% did not proceed with the extraction. Of the remaining 10 patients, 60% had clinical success and 40% had a clinical failure with the extraction. Subsequent device upgrades or revisions were performed in 18.3% of patients in the LA group and 31.6% in the TLE group, with no significant differences in procedural challenges such as requiring balloon venoplasty or serial dilation (5.2% vs. 5.3%, P=1.0). There was no difference in 10-year survival probability among LA group and TLE group (P=0.64). Conclusion: Indications for subsequent extraction arose in 9.1% of patients with the initial LA approach for sterile leads after an average of 7.3 years and 28.6% did not proceed with the extraction. Of the patients who underwent the subsequent extraction, 60% had clinical success and 40% had a clinical failure. There was no difference in 10-year survival probability between patients with the initial LA approach or TLE approach.