gebhart/patrepeval huggingface dataset:
Autoexamen de mamas en estudiantes de una Universidad Pública del Caribe Colombiano (2023)

Introducción: el autoexamen de mamas (AEM) es considerado el método más relevante, simple, asequible para prevenir y diagnosticar tempranamente cáncer de mama. Objetivo: Evaluar conocimientos, actitudes y prácticas sobre autoexamen de mama en universitarias del área de la salud. Métodos: Estudio de corte transversal realizado en 400 estudiantes de sexo femenino de una universidad pública. Se aplicó cuestionario anónimo ad-hoc de auto reporte, que incluía variables sociodemográficas y relacionadas con conocimientos, actitudes y prácticas sobre AEM. Datos analizados a partir de proporciones, regresión de Poisson estimando razones de prevalencias y asociaciones con intervalo de confianza de 95%. Resultados: 55,7%, 51,0% y 54,5 % presentaban adecuados conocimientos, actitudes y prácticas hacia AEM, respectivamente. En análisis multivariado el modelo que mejor explica conocimientos inadecuados fue ser adolescentes (RP=1,36), procedencia rural (RP=1,30), estudiar en programas no relacionados con AEM (RP=1,92) y consumir alcohol (RP= 1,28); actitudes inadecuadas: pertenecer a programas no relacionados con AEM (RP=1,44) y consumir alcohol (RP=1,48) y prácticas inadecuadas con ser adolescente (RP= 1,74) y pertenecer a programas no relacionados con AEM (RP=1,37). Conclusiones: Conocimientos, actitudes y prácticas inadecuadas sobre AEM en universitarias se encuentran asociados con edad, procedencia, consumo de alcohol y estudiar en programa académico no relacionado con AEM, ofreciendo luces específicas a intervenir desde la promoción en salud.
Recent Advances in Peroxisome Proliferator- Activated Receptor Science (2005)

The peroxisome proliferator-activated receptor (PPAR) family of nuclear receptors, a set of three receptor sub-types encoded by distinct genes, function as lipid sensors to regulate a broad range of genes in many metabolically active tissues. Synthetic PPAR agonists have exhibited therapeutic benefits in treating diabetes and cardiovascular diseases. The discovery of PPAR-specific ligands has led to significant advancement in our understanding of the structure of these receptor proteins and the molecular mechanism of their ligand-dependent activation. Herein, we present both recent progress in the functional analysis of these orphan receptors and the confirmation of the PPARs as molecular targets for the development of new medicines to treat human metabolic disease.
Laser Raman spectroscopy used to study the ocean at 3600‐m depth (2002)

Making geochemical measurements in the deep ocean is fundamentally difficult. For this reason, century‐old technologies using water bottles and cores for sample recovery still provide the basic tools. With the development of research submersibles and remotely operated vehicles (ROVs), however, new opportunities for sophisticated sampling and analysis have arisen.
Abstract 161 (2014)

AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK
An experimentally-informed coarse-grained 3-site-per-nucleotide model of DNA: Structure, thermodynamics, and dynamics of hybridization (2013)

A new 3-Site-Per-Nucleotide coarse-grained model for DNA is presented. The model includes anisotropic potentials between bases involved in base stacking and base pair interactions that enable the description of relevant structural properties, including the major and minor grooves. In an improvement over available coarse-grained models, the correct persistence length is recovered for both ssDNA and dsDNA, allowing for simulation of non-canonical structures such as hairpins. DNA melting temperatures, measured for duplexes and hairpins by integrating over free energy surfaces generated using metadynamics simulations, are shown to be in quantitative agreement with experiment for a variety of sequences and conditions. Hybridization rate constants, calculated using forward-flux sampling, are also shown to be in good agreement with experiment. The coarse-grained model presented here is suitable for use in biological and engineering applications, including nucleosome positioning and DNA-templated engineering.
Planning and Optimization of Cellular Networks through Centroidal Voronoi Tessellations (2015)

The fifth generation (5G) of wireless networks will connect not only persons but also things, in a massive and previously unheard-of scale. Therefore, engineers and researchers need to develop methods and solutions to 1) satisfy the increasing demand, and 2) plan, maintain, and optimize networks that are envisioned to provide services to a highly dynamic, diverse, and heterogeneous traffic, both in time and space. This paper makes a contribution to the second goal by introducing an idea for planning and/or optimization of cellular networks based on the use of Centroidal Voronoi Tessellations. The framework allows obtaining (deterministically) network topologies that are compatible with the service demand, described statistically in terms of its spatial distribution and volume. While the method provides by itself a first network performance assessment, site locations and cell areas, are key references for planning and optimization.
Geomagnetism for Smartphone-Based Indoor Localization (2017)

Geomagnetism has recently attracted considerable attention for indoor localization due to its pervasiveness and independence from extra infrastructure. Its location signature has been observed to be temporally stable and spatially discernible for localization purposes. This survey examines and analyzes the recent challenges and advances in geomagnetism-based indoor localization using smartphones. We first study smartphone-based geomagnetism measurements. We then review recent efforts in database construction and computation reduction, followed by state-of-the-art schemes in localizing the target. For each category, we identify practical deployment challenges and compare related studies. Finally, we summarize future directions and provide a guideline for new researchers in this field.
Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat ? opioid receptor (1998)

Mutational analysis of opioid receptors supports the hypothesis that dissimilar receptor domains contribute to the binding affinity of different ligands. To determine whether enantiomeric ligands can serve to distinguish between different binding pockets (which focuses the analysis on asymmetric structural factors while avoiding confounding changes in physiochemical characteristics), we analyzed the binding of the 3-methylfentanyl congeners RTI-4614-4 [(+/-)-cis-N-[1-(2-hydroxy-2-phenylethyl)-3-methyl-4-piperidyl]-N- phenylpropanamide HCl)], its four stereoisomers [(2S,3R,4S)-1a, (2R,3R,4S)-1b, (2R,3S,4R)-1c, and (2S,3S,4R)-1d], and other mu agonists with cloned rat mu opioid receptors stably expressed in HEK-293 cells and mu/kappa receptor chimeras. Chimera III (kappa[aminoacids 1-141]/mu[aminoacids 151-398]), chimera IV (mu[aminoacids 1-150]/kappa[aminoacids 142-380]), and chimera XII (kappa[aminoacids 1-262]/mu[aminoacids 269-398]) bound [(125)I]IOXY (6beta-iodo-3,14-dihydoxy-17-cyclopropylmethyl-4,5alpha++ +-epoxymorphinan) with high affinities. The Ki values of 1a, 1b, 1c, and 1d at the wild-type mu receptor were 0.55 nM, 0.66 nM, 124 nM, and 59.2 nM, respectively. When the region from the N terminal to the start of the transmembrane helix 3 (TMH3) of the mu receptor was substituted by that of the kappa receptor (chimera III), the Ki value of 1b was increased (relative to the mu receptor) 590-fold compared to a 73-fold increase for 1a. When this portion of the kappa receptor was replaced by that of the mu receptor (chimera IV), the loss of affinity was not as great: 11.7-fold for 1a and 58.5-fold for 1b. Replacement of the middle of the third intracellular loop and third extracellular loop (e3) of the kappa receptor with that of the mu receptor (chimera XII) lowered (relative to their Ki values at the kappa receptor) the Ki values of [D-Ala2,D-Leu5]enkephalin and [D-Ala2-MePhe4,Gly-ol5]enkephalin to a much greater extent than the Ki values of the isomers. The kappa/chimera XII shift was greater for isomers 1c and 1d than for 1b and 1a. Viewed collectively, these data suggest that the region from the N terminal to the start of the TMH3 of the mu opioid receptor determines the binding affinity of RTI-4614-4 and its isomers and that the e3 loop also plays a major role in determining the binding affinity of mu agonist peptides. These data also show that the stereoisomers of RTI-4614-4 probably bind to different domains of the mu receptor and suggest that manipulation of stereochemistry may be a useful tool for designing domain-specific ligands.
Phytochromes mediate germination inhibition under red, far-red, and white light in Aethionema arabicum (2022)

Abstract The view on the role of light during seed germination stems mainly from studies with Arabidopsis , where light is required to initiate this process. In contrast, white light is a strong inhibitor of germination in other plants, exemplified by accessions of Aethionema arabicum , another Brassicaceae. Their seeds respond to light with gene expression changes of key regulators converse to Arabidopsis , resulting in antipodal hormone regulation and prevention of germination. The photoreceptors involved in this process in A. arabicum were unknown. Screening the first mutant collection of A. arabicum , we identified koy-1 , a mutant that lost light inhibition of germination, due to a deletion in the promoter of HEME OXYGENASE 1 , the gene for a key enzyme in the biosynthesis of the phytochrome chromophore. koy-1 seeds are unresponsive to red- and far-red light and hyposensitive under white light. Comparison of hormone and gene expression between wild type and koy- 1 revealed that very low light fluence stimulates germination, while high irradiance of red and far-red light is inhibitory, indicating a dual role of phytochromes in light-regulated seed germination. The mutation also affects the ratio between the two fruit morphs of A. arabicum , suggesting that light reception via phytochromes can fine-tune several parameters of propagation in adaptation to conditions in the habitat. One sentence summary Characterization of a phytochrome chromophore biosynthesis mutant demonstrates an active role of phytochromes in the light-inhibited seed germination in Aethionema arabicum .
Design Techniques and Modeling for 60GHz Applications With a 65nm-CMOS-RF Technology (2008)

International audience
Dose quantification in carbon ion therapy using in-beam positron emission tomography (2020)

This work presents an iterative method for the estimation of the absolute dose distribution in patients undergoing carbon ion therapy, via analysis of the distribution of positron annihilations resulting from the decay of positron-emitting fragments created in the target volume. The proposed method relies on the decomposition of the total positron-annihilation distributions into profiles of the three principal positron-emitting fragment species - <sup>11</sup>C, <sup>10</sup>C and <sup>15</sup>O. A library of basis functions is constructed by simulating a range of monoenergetic <sup>12</sup>C ion irradiations of a homogeneous polymethyl methacrylate phantom and measuring the resulting one-dimensional positron-emitting fragment profiles and dose distributions. To estimate the dose delivered during an arbitrary polyenergetic irradiation, a linear combination of factors from the fragment profile library is iteratively fitted to the decomposed positron annihilation profile acquired during the irradiation, and the resulting weights combined with the corresponding monoenergetic dose profiles to estimate the total dose distribution. A total variation regularisation term is incorporated into the fitting process to suppress high-frequency noise. The method was evaluated with 14 different polyenergetic <sup>12</sup>C dose profiles in a polymethyl methacrylate target: one which produces a flat biological dose, 10 with randomised energy weighting factors, and three with distinct dose maxima or minima within the spread-out Bragg peak region. The proposed method is able to calculate the dose profile with mean relative errors of 0.8%, 1.0% and 1.6% from the <sup>11</sup>C, <sup>10</sup>C, <sup>15</sup>O fragment profiles, respectively, and estimate the position of the distal edge of the SOBP to within an average of 0.7 mm, 1.9 mm and 1.2 mm of its true location.
Field Evaporation Behavior of Ternary Compound Semiconductor InxAli-xN (2017)

III-nitride binary and ternary compound semiconductors are essential for the development of highfrequency and high-power electronic and optoelectronic devices operating in the ultraviolet spectral region due to their wide band gap and unique electronic characteristics. InAlN is attracting much attention due to its lattice matching capability to GaN substrates and its variable band gap energy which can be tuned from 1.9 to 6.2 eV In order to facilitate high performance devices, structural and chemical information must be obtained and optimized at the nanoscale level. In the past decade, atom probe tomography (APT) has emerged as one of the most powerful techniques to analyze semiconductors and device structures at the sub-nanometer scale However, studying III-Nitride heterosturctures using atom probe has been a challenge due to compound semiconductors exhibiting a complex field evaporation behavior In this work we have made both experimental and theoretical efforts to understand the field evaporation behavior of ternary alloy InxAl1-xN in a multilayer stack with GaN.
Bibliometrics as Weapons of Mass Citation La bibliométrie comme arme de citation massive (2010)

The allocation of resources for research is increasingly based on so-called 'bibliometrics'. Scientists are now deemed to be successful on the sole condition that their work be abundantly cited. This world-wide trend appears to enjoy support not only by granting agencies (whose task is obviously simplified by extensive recourse to bibliometrics), but also by the scientists themselves (who seem to enjoy their status of celebrities). This trend appears to be fraught with dangers, particularly in the area of social sciences, where bibliometrics are less developed, and where monographs (which are not taken into account in citation indexes) are often more important than articles published in journals. We argue in favour of a return to the values of 'real science', in analogy to the much-promised return to a 'real economy'. While economists may strive towards a more objective evaluation of the prospects of a company, a market, or an industrial sector, we scientists can only base our appraisal on a responsible practice of peer review. Since we fear that decision-takers of granting agencies such as the FNRS, CTI, EPFL, ETHZ, ANR, CNRS, NIH, NSF, DOE, etc. will be too busy to read our humble paper in Chimia, we appeal to scientists of all countries and disciplines to unite against the tyranny of bibliometrics.
Flow cytofluorometric analysis of insulin binding and internalization by swiss 3T3 cells (1982)

The binding of a fluorescein-isothiocyanate derivative of insulin to Swiss 3T3 cells was measured by flow cytometry. The kinetics of the subsequent internalization were also measured; at a concentration of 1 microM labeled insulin approximately 25% of the internalization was insulin-specific. The kinetics of endocytosis were contrasted to those of fluorescent derivatives of histone and dextran. In addition, the fusion of endocytic vesicles containing insulin or dextran with lysosomes was detected by measuring the pH-dependent increase in fluorescein fluorescein fluorescence caused by the addition of chloroquine. The application of these results to the analysis of growth control by insulin and related hormones is discussed.
A Novel Craniotomy Simulator Provides a Validated Method to Enhance Education in the Management of Traumatic Brain Injury (2013)

The CNS simulation trauma module provides a complementary method for residents to acquire necessary skills in the management of traumatic brain injury. Preliminary data indicate improvement in didactic and hands-on knowledge after training. Additional data are needed to confirm the validity of the simulator.
Dynamic Nuclear Polarization of Long-Lived Nuclear Spin States in Methyl Groups (2017)

We have induced hyperpolarized long-lived states in compounds containing <sup>13</sup>C-bearing methyl groups by dynamic nuclear polarization (DNP) at cryogenic temperatures, followed by dissolution with a warm solvent. The hyperpolarized methyl long-lived states give rise to enhanced antiphase <sup>13</sup>C NMR signals in solution, which often persist for times much longer than the <sup>13</sup>C and <sup>1</sup>H spin-lattice relaxation times under the same conditions. The DNP-induced effects are similar to quantum-rotor-induced polarization (QRIP) but are observed in a wider range of compounds because they do not depend critically on the height of the rotational barrier. We interpret our observations with a model in which nuclear Zeeman and methyl tunnelling reservoirs adopt an approximately uniform temperature, under DNP conditions. The generation of hyperpolarized NMR signals that persist for relatively long times in a range of methyl-bearing substances may be important for applications such as investigations of metabolism, enzymatic reactions, protein-ligand binding, drug screening, and molecular imaging.
Age-dependent cut-offs for pathological deep gray matter and thalamic volume loss using Jacobian integration (2020)

It might be methodologically feasible to assess deep GMVL using JI in individual MS patients. However, age and the measurement error need to be taken into account. Furthermore, deep GMVL may be used as a complementary marker to BVL since MS patients exhibit a significantly stronger deep GMVL than BVL.
A Novel Stromal Cell-Dependent B Lymphoid Stem-Like Cell Line That Induces Immunoglobulin Gene Rearrangement (1999)

A stroma-dependent B lymphoid cell line (B31-1) has been established by coculturing sorted stem cells on a novel bone marrow stromal cell line (TBR31-1). B31-1 cells express B220, but do not express other B lymphoid differentiation markers including CD43, heat stable antigen (HSA), or surface immunoglobulin (Ig) M (sIgM), and their Ig heavy chain (IgH) gene loci are germ-line in configuration. The addition of interleukin (IL)-7 or coculture with another stromal cell line, ST2, induces D-J rearrangement of the IgH gene and B lymphocyte differentiation markers. B31-1 cells restore an in vivo repopulation activity to lethally irradiated mice, and the repopulated cells differentiate to HSA+ pre-B cells.Continuous coculture results in two distinct populations, B220(-) c-Kit+ cells and B220(+) c-Kit+ cells; B220(-) c-Kit+ cells are self-renewed and differentiate to B220(+) c-Kit+ cells, while B220(+) c-Kit+ cells produce only B220(+) c-Kit+ cells. Both B220(-) and B220(+) cells similarly express the IgH germ-line transcript (Imu), mRNAs for recombinase (TdT, Rag-1, and Rag-2), and lymphoid-specific transcription factors (Pax-5, EBF, E12/E47, Oct-2, and Ikaros), but the DNA binding activity of Pax-5, EBF, Oct-2, and E2A are low in B220(-) cells and while high in B220(+) cells. These results suggest the existence of at least two active states in the IgH locus before the induction of IgH gene rearrangement during B lymphopoietic development.
Radiation pattern analysis for reflector antennas using the near-field measurements of primary feed (2016)

We investigate a radiation pattern analysis method for reflector antennas using near-field measurements of primary feed. Using the plane-wave spectrum obtained through near-field measurement, it is possible to find the incident electromagnetic field not only at an arbitrary plane, but also at each point of the reflector. This paper describes the analysis method, and verifies its validity by using array-fed reflector antenna.
The Blessing and the Curse of the Noise behind Facial Landmark Annotations (2020)

The evolving algorithms for 2D facial landmark detection empower people to recognize faces, analyze facial expressions, etc. However, existing methods still encounter problems of unstable facial landmarks when applied to videos. Because previous research shows that the instability of facial landmarks is caused by the inconsistency of labeling quality among the public datasets, we want to have a better understanding of the influence of annotation noise in them. In this paper, we make the following contributions: 1) we propose two metrics that quantitatively measure the stability of detected facial landmarks, 2) we model the annotation noise in an existing public dataset, 3) we investigate the influence of different types of noise in training face alignment neural networks, and propose corresponding solutions. Our results demonstrate improvements in both accuracy and stability of detected facial landmarks.
Síntesis de péptidos para el reconocimiento de secuencias específicas del ADN (2001)

El proceso de la transcripcion genetica es fundamental en el control del desarrollo y funcionamiento celular. Se ha demostrado la relacion entre desajustes del control transcripcional con enfermedades como el cancer; es por lo tanto de gran importancia la comprension de las bases moleculares de dicho control. La transcripcion genetica esta regulada por proteinas que se unen al ADN de forma especifica llamadas factores de transcripcion.
El objetivo del presente trabajo de tesis es el diseno y sintesis de analogos peptidicos del factor de transcripcion de levaduras GCN4. Dicho factor de transcripcion interacciona con el surco mayor del ADN en forma de dimero.
El diseno de las moleculas sintetizadas simplifica el motivo de union al ADN tomando unicamente uno de los monomeros, mimetizando el otro por medio de una molecula pequena capaz de unirse al surco menor del ADN. Se llevo a cabo la sintesis y evaluacion de la capacidad de union de diversas moleculas formadas por la union covalente de la region de reconocimiento del GCN4 con analogos de la Distamicina, cuya union al surco menor del ADN ha sido ampliamente documentada. Las pruebas llevadas a cabo mediante tecnicas de Dicroismo circular y Desplazamiento en Gel de Poliacrilamida demostraron la capacidad de union al ADN de uno de los analogos sintetizados, con una constante de afinidad en el rango de concentraciones nano Molar. Dichos experimentos tambien demostraron la importancia de la cadena que conecta la region basica del GCN4 con el tripirrol analogo de la Distamicina para permitir la union al ADN de forma especifica.