gebhart/patrepeval huggingface dataset:
The Epidemiology of Cardiac Surgery-Associated Acute Kidney Injury (2008)

Existing data on the epidemiology of CSA-AKI are difficult to compare due to variations in definition and patient cohort. A modified Delphi analysis resulted in a series of recommendations for future research on CSA-AKI.
New era in gene therapy: end of the beginning (2015)

Despite recent progress in effective biologic drugs, such as monoclonal antibodies, there are still a number of diseases for which no known effective therapy exists, such as inherited genetic disor...
Experimental Study on the Influence of Pressure on the Flame Stabilization in Porous Inert Media (PIM) (2012)

Porous burners offer a possible solution to attain higher combustion stability under premixed conditions with ultra low pollutant emissions. To analyze the feasibility of PIM (porous inert media) in energy conversion processes, studies at elevated pressure have been carried out. In the present work, burning velocity of natural gas-air mixtures for lean mixture conditions at elevated pressure is obtained in a conical PIM by determining the flame location using thermocouples. Pressure, thermal power, equivalence ratio and initial temperature were varied in order to study their effect on the flame stability. The pressure was varied from 1.1 to 14.0 bar, and initial temperatures from 300 to 400K. The burning velocity data obtained from present measurements show good agreement with literature data at atmospheric pressure. The results show that the burning velocities measured in PIM decreased non-linearly with increase in pressure. Also, the decrease in the burning velocity in the PIM with pressure is more pronounced for lean mixture conditions. Present results indicate that the PIM produces stable flames for a wide range of operating conditions and generate low pollutant emissions, which show that it is a potential alternative for conventional burners.
In Vivo Administration to Rhesus Monkeys of a CD4-Specific Monoclonal Antibody Capable of Blocking AIDS Virus Replication (1993)

Monoclonal antibodies (mAbs) specific for CD4 are potent inhibitors of HIV replication in vitro. These agents may be useful prophylactically or in chronic HIV infection if they can be administered without inducing immunosuppression. In the present study, we explored the safety of a CD4-specific murine mAb in rhesus monkeys. The mAb 5A8, which binds to domain 2 of the CD4 molecule, inhibits AIDS virus replication noncompetitively at a postvirus binding step. This antibody, which had a similar affinity for rhesus monkey and human CD4 cells, efficiently inhibited in vitro replication of both HIV-1 and the simian immunodeficiency virus of macaques. A single 3-mg/kg injection of mAb 5A8 into normal rhesus monkeys coated all circulating and lymph node CD4 cells for 4-6 days. CD4 cells were not cleared from circulation nor was the CD4 molecule modulated from the lymphocyte surface. In fact, administration of mAb 5A8 resulted in an approximately one-to twofold increase in absolute number of circulating CD4 cells. Repeated administration in normal rhesus monkeys resulted in CD4 lymphocyte coating with mAbs for > 9 days without CD4 cell clearance or modulation. While coated with mAbs, PBLs of these monkeys retained normal in vitro proliferative responses to mitogens and these animals generated normal humoral responses in vivo to tetanus toxoid. Loss of cell coating with mAbs in normal monkeys corresponded to the appearance of anti-mouse immunoglobulin antibodies. Thus, administration of certain anti-CD4 mAbs capable of blocking HIV replication can achieve coating of the entire CD4 cell pool in rhesus monkeys without inducing significant cell loss or immunosuppression.
Silica Nanoparticle Formation by Using Droplet-Based Microreactor (2017)

This paper describes a method for the synthesis of silica nanoparticles that can be later used for coating of quantum dots inside a microfluidic reactor. Here, a droplet-based system is used where two reagents were mixed inside the droplets to obtain silica. Particles in the size range of 25±2.7 nm were obtained with comparable size distribution to controlled batch-wise synthesis methods. This method is suitable to be used later to coat CdSe nanoparticles inside the microreactor.
Transmission subspace tracking for MIMO communications systems (2002)

This paper describes the benefits of transmission subspace tracking for multiple input multiple output communications systems, and applies the concepts of previous work on adaptive transmit antenna algorithms to this problem. A specific stochastic gradient technique of subspace or "multi-mode" tracking of the independent modes of the MIMO transfer function and the application to space time coding is considered. The technique provides gains by tracking the active modes when there are more transmit than receive antennas. With the proposed algorithm, the receiver generates binary feedback selecting preferred perturbed weights, which gives the transmitter a gradient estimate useful for subspace tracking. The capacity resulting from this approach is shown by simulation.
Optimizing Well Placement Planning in the Presence of Subsurface Uncertainty and Operational Risk Tolerance (2010)

This paper presents an automated workflow to accelerate the well placement planning process in the presence of subsurface uncertainty and operational risk. The system allows the user to screen and rank development options in minutes. This automated field development planning system is an optimization application, integrated with a larger seismic-to-simulation workflow. A key piece of technology in this system is a high-speed semi-analytical reservoir simulator, which enables an optimal strategy to be computed very rapidly. The system also embeds key technologies for optimization in the presence of uncertainty and risk which leverages an advanced uncertainty framework. The workflow starts with a reservoir model, along with existing wells and other operational constraints. Oil or gas production is computed using the high-speed reservoir simulator. Proposed well trajectories honor operational constraints, such as facility processing, water injection capacity, borehole dogleg severity, anti-collision with existing wells, and hazard avoidance on the surface and in the reservoir. The optimal strategy proposes well surface locations, trajectories, and completion locations and is calculated by optimizing the value e.g., net present value (NPV) or production. This new methodology has many applications in the field development planning context. We are able to rapidly screen multiple field development planning scenarios and produce an optimal new/infill drilling strategy with primary production or waterflooding consisting of both newly proposed and existing wells. The final result includes performance predictions based on an optimized field development plan (FDP), risk, and subsurface uncertainties. The most promising scenarios can if necessary be used subsequently for detailed numerical simulation in order to validate results.
Fluorescent Zinc Sensor with Minimized Proton-Induced Interferences: Photophysical Mechanism for Fluorescence Turn-On Response and Detection of Endogenous Free Zinc Ions (2012)

A new fluorescent zinc sensor (HNBO-DPA) consisting of 2-(2'-hydroxy-3'-naphthyl)benzoxazole (HNBO) chromophore and a di(2-picolyl)amine (DPA) metal chelator has been prepared and examined for zinc bioimaging. The probe exhibits zinc-induced fluorescence turn-on without any spectral shifts. Its crystal structure reveals that HNBO-DPA binds a zinc ion in a pentacoordinative fashion through the DPA and HNBO moieties. Steady-state photophysical studies establish zinc-induced deprotonation of the HNBO group. Nanosecond and femtosecond laser flash photolysis and electrochemical measurements provide evidence for zinc-induced modulation of photoinduced electron transfer (PeT) from DPA to HNBO. Thus, the zinc-responsive fluorescence turn-on is attributed to suppression of PeT exerted by deprotonation of HNBO and occupation of the electron pair of DPA, a conclusion that is further supported by density functional theory and time-dependent density functional theory (DFT/TD-DFT) calculations. Under physiological conditions (pH 7.0), the probe displays a 44-fold fluorescence turn-on in response to zinc ions with a K(d) value of 12 pM. The fluorescent response of the probe to zinc ions is conserved over a broad pH range with its excellent selectivity for zinc ions among biologically relevant metal ions. In particular, its sensing ability is not altered by divalent transition metal ions such as Fe(II), Cu(II), Cd(II), and Hg(II). Cell experiments using HNBO-DPA show its suitability for monitoring intracellular zinc ions. We have also demonstrated applicability of the probe to visualize intact zinc ions released from cells that undergo apoptosis. More interestingly, zinc-rich pools in zebrafish embryos are traced with HNBO-DPA during early developmental stages. The results obtained from the in vitro and in vivo imaging studies demonstrate the practical usefulness of the probe to detect zinc ions.
Detecting hepatic steatosis using ultrasound-induced thermal strain imaging: anex vivoanimal study (2014)

Hepatic steatosis or fatty liver disease occurs when lipids accumulate within the liver and can lead to steatohepatitis, cirrhosis, liver cancer and eventual liver failure requiring liver transplant. Conventional brightness mode (B-mode) ultrasound (US) is the most common noninvasive diagnostic imaging modality used to diagnose hepatic steatosis in clinics. However, it is mostly subjective or requires a reference organ such as the kidney or spleen with which to compare. This comparison can be problematic when the reference organ is diseased or absent. The current work presents an alternative approach to noninvasively detecting liver fat content using US-induced thermal strain imaging (US-TSI). This technique is based on the difference in the change in the speed of sound as a function of temperature between water- and lipid-based tissues. US-TSI was conducted using two system configurations including a mid-frequency scanner with a single linear array transducer (5-14 MHz) for both imaging and heating and a high-frequency (13-24 MHz) small animal imaging system combined with a separate custom-designed US heating transducer array. Fatty livers (n = 10) with high fat content (45.6 ± 11.7%) from an obese mouse model and control livers (n = 10) with low fat content (4.8 ± 2.9%) from wild-type mice were embedded in gelatin. Then, US imaging was performed before and after US induced heating. Heating time periods of ∼ 3 s and ∼ 9.2 s were used for the mid-frequency imaging and high-frequency imaging systems, respectively, to induce temperature changes of approximately 1.5 °C. The apparent echo shifts that were induced as a result of sound speed change were estimated using 2D phase-sensitive speckle tracking. Following US-TSI, histology was performed to stain lipids and measure percentage fat in the mouse livers. Thermal strain measurements in fatty livers (-0.065 ± 0.079%) were significantly (p < 0.05) higher than those measured in control livers (-0.124 ± 0.037%). Using histology as a gold standard to classify mouse livers, US-TSI had a sensitivity and specificity of 70% and 90%, respectively. The area under the receiver operating characteristic curve was 0.775. This ex vivo study demonstrates the feasibility of using US-TSI to detect fatty livers and warrants further investigation of US-TSI as a diagnostic tool for hepatic steatosis.
Spatial Profiles of Electrical Mismatch Determine Vulnerability to Conduction Failure Across a Host–Donor Cell Interface (2013)

Our results quantify how the degree of electrical mismatch across a cardiomyocyte-donor cell interface affects vulnerability to conduction block, with important implications for the design of safe cardiac cell and gene therapies.
Parallel Computation of Skyline Queries (2013)

Due to stagnant clock speeds and high power consumption of commodity microprocessors, database vendors have started to explore massively parallel co-processors such as FPGAs to further increase performance. A typical approach is to push simple but compute-intensive operations (e.g., prefiltering, (de)compression) to FPGAs for acceleration. In this paper, we show how a significantly more complex operation- the computation of the skyline-can be holistically implemented on an FPGA. A skyline query computes the pareto optimal set of multi-dimensional data points. These queries have been studied in software extensively over the last decade but this paper is the first to examine skyline computation in hardware. We propose a methodology that interleaves data storage and computation, allowing multiple operations to be executed on the same working set in parallel, while accounting for all data dependencies. Our experiments show that we achieve very promising results compared to CPU-based solutions.
Synthesis of Conjugation‐Expanded Porphyrins Based on the Retro Diels—Alder Reaction (2002)

Abstract For Abstract see ChemInform Abstract in Full Text.
Rapid Automated Annotation and Analysis of N-Glycan Mass Spectrometry Imaging Data Sets Using NGlycDB in METASPACE (2021)

Imaging N-glycan spatial distribution in tissues using mass spectrometry imaging (MSI) is emerging as a promising tool in biological and clinical applications. However, there is currently no high-throughput tool for visualization and molecular annotation of N-glycans in MSI data, which significantly slows down data processing and hampers the applicability of this approach. Here, we present how METASPACE, an open-source cloud engine for molecular annotation of MSI data, can be used to automatically annotate, visualize, analyze, and interpret high-resolution mass spectrometry-based spatial N-glycomics data. METASPACE is an emerging tool in spatial metabolomics, but the lack of compatible glycan databases has limited its application for comprehensive N-glycan annotations from MSI data sets. We created NGlycDB, a public database of N-glycans, by adapting available glycan databases. We demonstrate the applicability of NGlycDB in METASPACE by analyzing MALDI-MSI data from formalin-fixed paraffin-embedded (FFPE) human kidney and mouse lung tissue sections. We added NGlycDB to METASPACE for public use, thus, facilitating applications of MSI in glycobiology.
Antitumor effect of piericidin B1 N-oxide. (1994)

Piericidin B1 N-oxide was isolated from a culture broth of Streptomyces sp. as a novel inhibitor of phosphatidylinositol (PI) turnover. Piericidin B1 N-oxide specifically inhibited orthophosphate labeling of PI induced by epidermal growth factor (EGF) without affecting the formation of phosphatidic acid (PA). Like piericidins A1 and B1, piericidin B1 N-oxide inhibited ATP synthesis in A431 cells; however, the effect of piericidin B1 N-oxide on PI synthesis was stronger than that of piericidins A1 and B1. At the concentration inhibiting PI synthesis, piericidin B1 N-oxide showed no inhibitory effect on DNA, RNA, or protein synthesis. We also demonstrated that piericidin B1 N-oxide reversibly inhibited the growth of A431 cells in situ and suppressed the growth of Ehrlich carcinoma in vivo when administered to mice by intraperitoneal (ip) injection.
Early Relapses in Primary CNS Lymphoma (PCNSL) without Intraventricular Treatment. (2007)

Abstract Background: A systemic and intraventricular polychemotherapy regimen (“Bonn protocol”) with deferred radiotherapy had resulted in durable responses in 75% of patients &lt; 60 years with primary CNS lymphoma (PCNSL), but had been complicated by a high rate of Ommaya reservoir infections. Purpose: Here, efficacy and toxicity of this regimen but without intraventricular treatment was evaluated in PCNSL. Patients and Methods : From 08/03 to 11/05, 18 patients with PCNSL &lt; 60 years (median age 53 years) were treated within a phase II trial with a high-dose methotrexate (MTX; cycles 1,2,4 and 5) and cytarabine (Ara-C; cycles 3 and 6) based systemic therapy including dexamethasone, vinca-alkaloids, ifosfamide and cyclophosphamide. Results: Study accrual was prematurely stopped in 11/05 due to a high rate of early relapses. Seventeen/18 patients were assessable for response: Nine (53%) achieved complete response (CR), two (12%) complete response/unconfirmed (CRu), two (12%) partial response (PR), four (24%) showed progressive disease (PD); in one treatment was stopped due to toxicity. Median follow-up is 23 months; Kaplan-Meier estimates for median response duration were ten months only in responding patients and for median time to treatment failure (TTF) eight months in the whole group; median overall survival (OS) has not yet been reached. Systemic toxicity was mainly hematologic. Conclusions: In patients &lt; 60 years with PCNSL polychemotherapy without intraventricular treatment results in a high response rate, but is associated with early relapses in the majority of cases. This is in contrast to the results achieved with the same protocol but with inclusion of intraventricular treatment.
Chemical and Enzymatic Synthesis of 1-Deoxy-d-xylulose-5-phosphate (1998)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTChemical and Enzymatic Synthesis of 1-Deoxy-d-xylulose-5-phosphateSean V. Taylor, Long D. Vu, Tadhg P. Begley, Ulrich Schörken, Sigrid Grolle, Georg A. Sprenger, Stephanie Bringer-Meyer, and Hermann SahmView Author Information Department of Chemistry, Cornell University, Baker Laboratory, Ithaca, New York 14853 Institut für Biotechnologie, 1 des Forschungszentrums Jülich GmbH, Postfach 1913, D-52425 Jülich, Germany Cite this: J. Org. Chem. 1998, 63, 7, 2375–2377Publication Date (Web):March 18, 1998Publication History Received20 October 1997Published online18 March 1998Published inissue 1 April 1998https://pubs.acs.org/doi/10.1021/jo971933phttps://doi.org/10.1021/jo971933pbrief-reportACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views642Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Bacteria,Biosynthesis,Chemical synthesis,Peptides and proteins,Precursors Get e-Alerts
A New Method for InGaAs/InP Composite ChannelHEMTs Simulation (2007)

A new method is used to simulate InGaAs/InP composite channel high electron mobility transistors (HEMTs).By coupling the hydrodynamic model and the density gradient model,the electron density distribution in the channel in different electric fields is obtained.This method is faster and more robust than traditional methods and should be applicable to other types of HEMTs simulations.A detailed study of the InGaAs/InP composite channel HEMTs is presented with the help of simulations.
Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRγ–Syk–Card9–dependent innate immune activation (2009)

Novel vaccination strategies against Mycobacterium tuberculosis (MTB) are urgently needed. The use of recombinant MTB antigens as subunit vaccines is a promising approach, but requires adjuvants that activate antigen-presenting cells (APCs) for elicitation of protective immunity. The mycobacterial cord factor Trehalose-6,6-dimycolate (TDM) and its synthetic analogue Trehalose-6,6-dibehenate (TDB) are effective adjuvants in combination with MTB subunit vaccine candidates in mice. However, it is unknown which signaling pathways they engage in APCs and how these pathways are coupled to the adaptive immune response. Here, we demonstrate that these glycolipids activate macrophages and dendritic cells (DCs) via Syk-Card9-Bcl10-Malt1 signaling to induce a specific innate activation program distinct from the response to Toll-like receptor (TLR) ligands. APC activation by TDB and TDM was independent of the C-type lectin receptor Dectin-1, but required the immunoreceptor tyrosine-based activation motif-bearing adaptor protein Fc receptor gamma chain (FcRgamma). In vivo, TDB and TDM adjuvant activity induced robust combined T helper (Th)-1 and Th-17 T cell responses to a MTB subunit vaccine and partial protection against MTB challenge in a Card9-dependent manner. These data provide a molecular basis for the immunostimulatory activity of TDB and TDM and identify the Syk-Card9 pathway as a rational target for vaccine development against tuberculosis.
Effectiveness and Pharmacokinetic Exposures of First-Line Drugs Used to Treat Drug-Susceptible Tuberculosis in Children: A Systematic Review and Meta-Analysis (2023)

There is large variability in outcomes, with an average of 82% favorable outcomes. Drug exposures are lower in children than in adults. Younger children and/or those with HIV are underexposed to RIF. Standardization of PK pediatric studies and individual patient data analysis with safety assessment are needed to inform optimal dosing.
Measurement of the ZZ production cross section and Z →ℓ+ℓ−ℓ′+ℓ′− branching fraction in pp collisions at s=13 TeV (2016)

Four-lepton production in proton-proton collisions, pp (Z/ * ) (Z/ * ) + -+ -, where , = e or , is studied at a center-of-mass energy of 13 TeV with the CMS detector at the LHC. The data sample corresponds to an integrated luminosity of 2.6 fb -1 . The ZZ production cross section, (pp ZZ) = 14.6 +1.9 -1.8 (stat) +0.5 -0.3 (syst) 0.2 (theo) 0.4 (lumi) pb, is measured for events with two opposite-sign, sameflavor lepton pairs produced in the mass region 60 < m + -, m + -< 120 GeV. The Z boson branching fraction to four leptons is measured to be B(Z + -+ -) = 4.9 +0.8 -0.7 (stat) +0.3 -0.2 (syst) +0.2 -0.1 (theo) 0.1 (lumi) 10 -6 for the four-lepton invariant mass in the range 80 < m + -+ -< 100 GeV and dilepton mass m + -> 4 GeV for all opposite-sign, same-flavor lepton pairs. The results are in agreement with standard model predictions.
Phenolic Constituents of Leaves of Diospyros Montana (2007)

Five flavonol glycosides (1–5) and two naphthalene dimer glycosides (7 and 8), including three new compounds (1, 2 and 8), were isolated from the leaves of Diospyros montana. The structures of the isolated compounds were determined by spectroscopic analysis. One of the isolated compounds (1) showed DPPH radical scavenging activity.
Connecting TV & PC (2009)

In-situ studies and evaluations are increasingly appreciated and requested by companies and developers. Direct feedback from the users is seen as important source to further improve a system, to make it usable, acceptable and useful to the users in a final stage. In this paper, we report the results from a conducted in-situ field study for a newly developed EPG (Electronic Program Guide) system. One of the main challenges of our research was to find the right methodological set up in order to gather direct and fast user feedback by bringing developers and users together in a real live setting. Thereby, it was important that the users could easily express their first impressions of the system in an engaging way. Based on our previous work, a creative and playful approach was selected and combined with a variation of the walkthrough method. In this paper we provide a description of the methods used, their combinations, and lessons learned throughout the one-week field study involving different stakeholders.