gebhart/patrepeval huggingface dataset:
Mediator-Related Symptoms and Anaphylaxis in Children with Mastocytosis (2021)

Mastocytosis is characterized by the pathological accumulation of mast cells (MC) in various organs. In these patients, MC may degranulate and thereby contribute to clinical symptoms, especially when a concomitant allergy is present. However, MC activation can not only be induced by high-affinity receptors for IgE, but also by anaphylatoxins, neuropeptides, IgG immune complexes, complement-components, drugs, products of bacteria or parasites, as well as physical factors such as heat, cold, vibration, stress, sun, or physical effort. Symptoms due to mediators released by activated MC may develop in adults suffering from systemic mastocytosis, but also evolve in children who usually have cutaneous mastocytosis (CM). Clinically, CM is otherwise characterized by typical brown, maculopapular skin lesions or mastocytoma associated with a positive Darier's sign. Pruritus and flushing are common and blistering may also be recorded, especially in diffuse CM (DCM). Pediatric patients with mastocytosis may also have gastrointestinal, respiratory, and neurologic complaints. Although anaphylaxis is not a typical finding, pediatric patients with massive skin involvement and high tryptase levels have a relatively high risk to develop anaphylaxis. This paper reviews MC mediator-related symptoms and anaphylaxis in children with mastocytosis, with special emphasis on risk factors, triggers, and management.
Catastrophic Degradation in Quantum Cascade Lasers Emitting at 8.4 &#x00B5;m (2014)

We report on catastrophic degradation in 8.4 µm InGaAs-InAlAs quantum cascade lasers using focused ion beam (FIB) and high-resolution transmission electron microscope (HR-TEM) techniques.
Analytical Method for Predicting the Air-Gap Flux of Interior-Type Permanent-Magnet Machines (2004)

This paper presents an analytical method to calculate the air-gap magnetic flux of interior-type permanent-magnet (IPM) machines taking into account the assembly gap and saturation in stator and rotor. Special considerations are given to the calculation of leakage flux in the nonlinear magnetic short circuit or the "magnetic bridges." An equivalent magnetic circuit was developed, and a computer-aided graphic analysis program calculated the magnet operating point. The Norton equivalent of flux concentration structures was studied. Agreements have been obtained between the results of the analytical model, finite-element analysis, and test results on prototype motors.
Random Access for Massive MIMO Systems with Intra-Cell Pilot Contamination (2015)

Massive MIMO systems, where the base stations are equipped with hundreds of antenna elements, are an attractive way to attain unprecedented spectral efficiency in future wireless networks. In the "classical" massive MIMO setting, the terminals are assumed fully loaded and a main impairment to the performance comes from the inter-cell pilot contamination, i.e., interference from terminals in neighboring cells using the same pilots as in the home cell. However, when the terminals are active intermittently, it is viable to avoid inter-cell contamination by pre-allocation of pilots, while same-cell terminals use random access to select the allocated pilot sequences. This leads to the problem of intra-cell pilot contamination. We propose a framework for random access in massive MIMO networks and derive new uplink sum rate expressions that take intra-cell pilot collisions, intermittent terminal activity, and interference into account. We use these expressions to optimize the terminal activation probability and pilot length.
Ultrasonic imaging technique in liquid and solid waveguides using spatio-temporal matched field (STMF) processing (2000)

A new ultrasonic imaging technique devoted to detection of defects located inside a solid or liquid rectangular waveguide is presented. The technique, based on the spatio-temporal Green functions computation and cross-correlation technique, extends the concept of the matched field processing (MFP) technique used in ocean acoustics. The principle of the spatio-temporal matched field (STMF) processing relies on the cross-correlation between echographic B-SCAN signals detected with a linear transducer array and replica functions. These replica functions, derived from the Green functions, are designed to match as close as possible the time delays of direct and reflected acoustic wavefronts. Experiments conducted in liquid and Duralumin solid waveguides demonstrate the ability of the STMF processing to improve the spatial resolution of ultrasonic images in waveguides. An improvement factor up to five is achieved when the ultrasonic images in waveguides computed with the STMF processing are compared to that predicted in the free space using conventional technique. Results of defects imaging with Lamb waves in Duralumin plates of finite width will also be presented and commented.
Histopathological Study of Brain from Cattle with Nervous Symptomatology (2015)

This study aim the identification of morphopatological changes of the central nervous system in cattle with clinical nervous symptoms. Studied animals were represented by brain samples from cattle with clinical nervous signs, received in the Morphopathology Department for diagnosis of TSEs and other neurological diseases. Application of diagnostic protocol for cattle with nervous symptoms is according to the diagram flow of the Manual of diagnostic for transmissible spongiform encephalopathies target category “live bovine, animals slaughtered or dead animals with showed clinical nervous signs, behavioral changes and that during 15 days clinical observation (according to clinical observation sheet) did not respond to treatment, the evolution of disease resulting in worsening progressively.” Were performed specific laboratory tests for diagnosis confirmation in this respect: rapid tests and confirmatory tests for BSE, virusological investigations for rabies and Aujeszky’ disease and bacteriological investigations for listeriosis. Were also carried out histological investigation of brain samples for highlight topohystopathological / patognomonic changes.
Propylene Solubility in Toluene and Isododecane (2003)

Abstract Propylene solubility in toluene and isododecane (2,2,4,6,6‐Pentamethylheptane, CA Registry# 13475‐82‐6) was measured at different temperatures and pressures, similar to the ones normally used to carry out propylene polymerizations through metallocene and Ziegler‐Natta catalysts. Experimental data were obtained with a gravimetric method, where experimental liquid phase compositions are measured at known temperature and pressure conditions. The experimental data were modeled with two different models: the Wilson excess Gibbs free energy model and an empirical model. Both modeling approaches may be recommended for analysis of kinetic data obtained for slurry propylene polymerizations in toluene and isododecane.
ChemInform Abstract: Gold‐Catalyzed Reduction Reactions (2013)

Abstract Review: 100 refs.
Discovery of VU6005649, a CNS Penetrant mGlu7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5-a]pyrimidines (2017)

Herein, we report the structure-activity relationships within a series of mGlu<sub>7</sub> PAMs based on a pyrazolo[1,5-<i>a</i>]pyrimidine core with excellent CNS penetration (<i>K</i><sub>p</sub>s > 1 and <i>K</i><sub>p,uu</sub>s > 1). Analogues in this series proved to display a range of Group III mGlu receptor selectivity, but VU6005649 emerged as the first dual mGlu<sub>7/8</sub> PAM, filling a void in the Group III mGlu receptor PAM toolbox and demonstrating <i>in vivo</i> efficacy in a mouse contextual fear conditioning model.
Solid-phase synthesis of defined 1,4-benzodiazepine-2,5-dione mixtures (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolid-phase synthesis of defined 1,4-benzodiazepine-2,5-dione mixturesDane A. Goff and Ronald N. ZuckermannCite this: J. Org. Chem. 1995, 60, 18, 5744–5745Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/jo00123a002https://doi.org/10.1021/jo00123a002research-articleACS PublicationsRequest reuse permissionsArticle Views352Altmetric-Citations87LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information Get e-Alerts
Iron Oxide Nanocrystals for Magnetic Hyperthermia Applications (2012)

Magnetic nanocrystals have been investigated extensively in the past several years for several potential applications, such as information technology, MRI contrast agents, and for drug conjugation and delivery. A specific property of interest in biomedicine is magnetic hyperthermia-an increase in temperature resulting from the thermal energy released by magnetic nanocrystals in an external alternating magnetic field. Iron oxide nanocrystals of various sizes and morphologies were synthesized and tested for specific losses (heating power) using frequencies of 111.1 kHz and 629.2 kHz, and corresponding magnetic field strengths of 9 and 25 mT. Polymorphous nanocrystals as well as spherical nanocrystals and nanowires in paramagnetic to ferromagnetic size range exhibited good heating power. A remarkable 30 °C temperature increase was observed in a nanowire sample at 111 kHz and magnetic field of 25 mT (19.6 kA/m), which is very close to the typical values of 100 kHz and 20 mT used in medical treatments.
Fast Deep Learning for Automatic Modulation Classification (2019)

In this work, we investigate the feasibility and effectiveness of employing deep learning algorithms for automatic recognition of the modulation type of received wireless communication signals from subsampled data. Recent work considered a GNU radio-based data set that mimics the imperfections in a real wireless channel and uses 10 different modulation types. A Convolutional Neural Network (CNN) architecture was then developed and shown to achieve performance that exceeds that of expert-based approaches. Here, we continue this line of work and investigate deep neural network architectures that deliver high classification accuracy. We identify three architectures - namely, a Convolutional Long Short-term Deep Neural Network (CLDNN), a Long Short-Term Memory neural network (LSTM), and a deep Residual Network (ResNet) - that lead to typical classification accuracy values around 90% at high SNR. We then study algorithms to reduce the training time by minimizing the size of the training data set, while incurring a minimal loss in classification accuracy. To this end, we demonstrate the performance of Principal Component Analysis in significantly reducing the training time, while maintaining good performance at low SNR. We also investigate subsampling techniques that further reduce the training time, and pave the way for online classification at high SNR. Finally, we identify representative SNR values for training each of the candidate architectures, and consequently, realize drastic reductions of the training time, with negligible loss in classification accuracy.
Kleine Moleküle, ganz groß: niedermolekulare immunonkologische Kombinationstherapien (2017)

Abstract Immunonkologische Therapien haben das Potenzial, das Arsenal klinisch verfügbarer Tumortherapien nachhaltig zu verändern. Um die bisher erzielten klinischen Erfolge weiter zu verbessern, suchen Forscher nach neuen Wirkstoffkombinationen, bei denen die Blockade von Checkpoint‐Proteinen das Rückgrat der Behandlung darstellt. In diesem Aufsatz wird die Bedeutung niedermolekularer Substanzen beleuchtet, die vielversprechend für die Entwicklung verbesserter Krebstherapien sind.
Mechanism-based enzyme inactivation using an allyl sulfoxide-allyl sulfenate ester rearrangement (1980)

2-Amino-4-chloro-5-(<i>p</i>-nitrophenylsulfinyl)pentanoic acid (1) has been synthesized and shown to induce mechanism-based inactivation of two pyridoxal phosphate dependent enzymes: (1) cystathionine γ-synthetase, which catalyzes a γ-replacement reaction in bacterial methionine biosynthesis; and (2) methionine γ-lyase, which catalyzes a γ-elimination reaction in bacterial methionine breakdown. The inactivations are irreversible and display saturation kinetics. Each enzyme incorporates roughly 1 mol of tritium per mol of enzyme monomer when inactivated by 2-amino-4-chloro-5-(<i>p</i>-nitro[<sup>3</sup>H]phenyl-sulfinyl)pentanoic acid (<b>la</b>), confirming that the modification of each protein is covalent and stoichiometric. Substoichiometric labeling (0.12 mol of tritium per mol of enzyme monomer) is given when methionine γ-lyase is fully inactivated by 2-amino-4-chloro-5-[<sup>3</sup>H]-5-<i>p</i>-nitrophenylsulfinyl)pentanoic acid (<b>lb</b>). Both enzymes, inactivated by <b>1</b>, are susceptible to reactivation by thiols. Inactivated cystathionine γ-synthetase recovers 25% of its catalytic activity upon incubation with excess dithiothreitol, while methinonine γ-lyase is 100% reactivated by dithiothreitol, mercaptoethanol, and mercaptopropionate. Reactivation generates <i>p</i>-nitrophenylthiolate anion, which forms, in the case of methionine γ-lyase, stoichiometrically with enzyme reactivated. Both enzymes are "protected" from inactivation by <b>1</b> in the presence of thiols, which simultaneously generates <i>p</i>-nitrophenylthiol. In the presence of dithiothreitol, the protection reaction gives <i>p</i>-nitrophenylthiol production with pseudo-first-order kinetics. 2-Amino-4-chloro-5-(<i>p</i>-tolylsulfinyl)pentanoic acid (<b>2</b>) and 2-amino-4-(<i>p</i>-nitrophenylsulfinyl)-5-chloropentanoic acid (<b>3</b>), the reverse regioisomer of <b>1</b>, have also been prepared and give no evidence of inactivation of either enzyme. The data are taken to indicate a novel form of suicide inactivation (Scheme II) wherein β-carbanion-assisted γ-halide elimination generates an allyl sulfoxide-enzyme-pyridoxal adduct (<b>4</b>) which undergoes spontaneous 2,3-sigmatropic rearrangement to an electrophilic allyl sulfenate ester (<b>5</b>). The latter is then captured by an enzymic nucleophile to give an inactive enzyme <b>6</b>, which may be a mixed disulfide or, less likely, a sulfenamide.
Dual targeting of glioblastoma with chimeric antigen receptor-engineered natural killer cells overcomes heterogeneity of target antigen expression and enhances antitumor activity and survival (2015)

Epidermal growth factor receptor (EGFR) and its mutant form EGFRvIII are overexpressed in a large proportion of glioblastomas (GBM). Immunotherapy with an EGFRvIII-specific vaccine has shown efficacy against GBM in clinical studies. However, immune escape by antigen-loss variants and lack of control of EGFR wild-type positive clones limit the usefulness of this approach. Chimeric antigen receptor (CAR)-engineered natural killer (NK) cells may represent an alternative immunotherapeutic strategy. For targeting to GBM, we generated variants of the clinically applicable human NK cell line NK-92 that express CARs carrying a composite CD28-CD3ζ domain for signaling, and scFv antibody fragments for cell binding either recognizing EGFR, EGFRvIII, or an epitope common to both antigens. <i>In vitro</i> analysis revealed high and specific cytotoxicity of EGFR-targeted NK-92 against established and primary human GBM cells, which was dependent on EGFR expression and CAR signaling. EGFRvIII-targeted NK-92 only lysed EGFRvIII-positive GBM cells, while dual-specific NK cells expressing a cetuximab-based CAR were active against both types of tumor cells. In immunodeficient mice carrying intracranial GBM xenografts either expressing EGFR, EGFRvIII or both receptors, local treatment with dual-specific NK cells was superior to treatment with the corresponding monospecific CAR NK cells. This resulted in a marked extension of survival without inducing rapid immune escape as observed upon therapy with monospecific effectors. Our results demonstrate that dual targeting of CAR NK cells reduces the risk of immune escape and suggest that EGFR/EGFRvIII-targeted dual-specific CAR NK cells may have potential for adoptive immunotherapy of glioblastoma.
1201 Approximation and DOE for Optimal Design Based on Metamodel (2012)

Simulations completely replaced physical tests in some product segments. Despite its acceptance as a design tool, optimal design seems yet to gain mainstream popularity. Statistical models called metamodels empirically that capture the input-output relationship of the analyses for evaluating objective functions and constraints are sometimes used for engineering optimal design. A variety of metamodels are proposed and put into practical use. It is important to select the accurate metamodeing techinque for cutting down the cost ant shoretning the development period. In the paper, we systematically compare popular metamodeling techniques to help constructing metamodels promptly and correctly. 8 metamodeling techniques and 5 sampling techniques are selected and evaluated by means of some example functions. Accordingly to these comparisons, it is demonstrated that some metamodeling and sampling techniques are superior to another techniques and that sampling techniques are very important if the sample size is small relative to the number of the design variables.
Highly Reliable Carbon Nanotube Transistors with Patterned Gates and Molecular Gate Dielectric (2009)

The prospect of realizing nanoscale transistors using individual semiconducting carbon nanotubes offers enormous potential, both as an alternative to silicon technology beyond conventional scaling limits and as a way to implement high-speed devices and circuits on flexible substrates. A significant challenge is the realization of low-voltage nanotube transistors with individually addressable gate electrodes that display large transconductance, steep subthreshold swing, and large on/off ratio. Their integration into circuits with large signal gain and good stability still needs to be demonstrated. Here, we demonstrate that these important goals can be achieved with the help of a bottom-gate device structure that combines patterned metal gates with a thin gate dielectric based on a molecular self-assembled monolayer. The obtained transistors operate with a gate-source voltage of 1 V and have a transconductance of 5 microS, a subthreshold swing of 68 mV/decade, and an on/off ratio of 10(7). To verify the excellent operational and shelf life stability, we show that the device performance does not degrade during 10,000 switching cycles and during storage under ambient conditions for more than 300 days. We also demonstrate that the device structure allows the implementation of unipolar logic circuits with good switching characteristics.
Biomaterials Informatics (2006)

This chapter contains sections titled: Introduction Background Tyrosine-Based Polymers as Biomaterials Combinatorial Biomaterials Analysis Biochemical Assays and Rapid Screening Computational Modeling Conclusions and Future Prospects References
Corrigendum: Ionizing Particle Radiation as a Modulator of Endogenous Bone Marrow Cell Reprogramming: Implications for Hematological Cancers (2015)

In the paper titled “Ionizing Particle Radiation as a Modulator of Endogenous Bone Marrow Cell Reprogramming: Implications for Hematological Cancers”, there was secretarial error made at our end in “Figure 1”, which should be corrected. At some point of the submission in Figure 1, A and B were disarranged in the slide. No other correction is needed as the text and figure legends are correct. We will here by upload the corrected file for Figure 1.
The interaction between electron and phonon localized in a double-barrier resonant tunneling diode (1993)

The electron-phonon interaction (the transition probability from the initial electronic state to the final state via the electron-phonon interaction) is analyzed when electrons and phonons are either extended or localized in a quantum system. Compared with the situation of the bulk material where all wave functions are extended, it is generally found that the electron-phonon interaction is reduced when one state is localized while it will be enhanced when more states involved in the interaction process become localized. It has been shown that the electron-phonon interaction is inversely proportional to the well width when all the states involved are localized. Special attention is then focused on the double-barrier resonant tunneling diode. A simple Monte Carlo scheme is developed to include the electron-phonon interaction process in the quantum well between two barriers. The numerically calculated I-V characteristics agrees much better with the experimental spectra if the electron-phonon interaction has been taken into account.
Chronic Deposition of A&#946; Influences Microcirculation in the Chronic Stage of Cerebral Ischemia (2013)

Although the linkage between vascular dysfunction and Alzheimer’s disease has received much attention, the influence of beta-amyloid (Aβ) deposits on microcirculation in the chronic stage of ischemic brain injury is unknown. To examine the relationship of Aβ with the microcirculation around Aβ deposits in the chronic stage of cerebral infarction, Wistar rats were exposed to permanent middle cerebral artery occlusion (MCAo). Microangiography using albuminfluorescein isothiocyanate was performed 3 months after MCAo, followed by immunohistochemistry with GFAP and Aβ. Two types of atrophic changes were observed in the thalamus of ischemic brains: mild atrophy and severe atrophy with tissue defects. In both types, the deposition of Aβ was observed in the ventroposterior lateral and ventroposterior medial nuclei of the thalamus. Although various patterns of microcirculation were observed in the thalamus, a high density of enlarged microvessels with reactive gliosis was often observed around Aβ deposits. Conversely, enlarged low-density microvessels with less reactive gliosis were observed in the Aβ deposits. Because the regions with reactive gliosis without Aβ deposits showed no changes in microcirculation and previous reports showed the proangiogenic and anti-angiogenic effects of Aβ in in vitro studies, we hypothesize that continuous Aβ deposits act directly on microvessels, rather than via reactive gliosis. Although further studies are necessary, therapeutic approaches to reduce Aβ deposits might be a promising approach to improve microcirculation in the thalamus in the chronic stage of ischemic stroke. Keywords: Amyloid Aβ, angiogenesis, blood-brain-barrier, cerebral ischemia, gliosis, microcirculation, microvessels, middle cerebral artery occlusion, thalamus, APP23.