gebhart/patrepeval huggingface dataset:
Molecular Engineering of Isomeric Benzofurocarbazole Donors for Photophysical Management of Thermally Activated Delayed Fluorescence Emitters (2020)

Benzofurocarbazole moieties are commonly used donor structures in the design of thermally activated delayed fluorescence (TADF) emitters. However, only 5 H-benzofuro[3,2-c]carbazole (34BFCz) has been reported and, to the best of our knowledge, no other benzofurocarbazole derivatives have been covered in the literature. In the present study, two further benzofurocarbazole moieties, 12 H-benzofuro[3,2-a]carbazole (12BFCz) and 7 H-benzofuro[2,3-b]carbazole (23BFCz), have been synthesized to investigate the effect of the donor structure on the photophysics and device parameters of TADF emitters. Two benzofurocarbazole-derived TADF emitters, 12-(2-(4,6-diphenyl-1,3,5-triazin-2-yl)phenyl)-12 H-benzofuro[3,2-a]carbazole (o12BFCzTrz) and 7-(2-(4,6-diphenyl-1,3,5-triazin-2-yl)phenyl)-7 H-benzofuro[2,3-b]carbazole (o23BFCzTrz), have been compared with 5-(2-(4,6-diphenyl-1,3,5-triazin-2-yl)phenyl)-5 H-benzofuro[3,2-c]carbazole (oBFCzTrz). The benzofurocarbazole donor structure governs the TADF characteristics, such as charge-transfer property and emission color. The 12BFCz donor has proved to be effective in blue-shifting the emission color, and 34BFCz has proven useful for improving the external quantum efficiency (EQE). The 12BFCz-derived o12BFCzTrz showed blue-shifted color coordinates of (0.159, 0.288), compared to (0.178, 0388) for o23BFCzTrz and (0.169, 0.341) for oBFCzTrz. The 34BFCz-derived oBFCzTrz exhibited an EQE of 22.9 %, compared to 19.2 % for o12BFCzTrz and 21.1 % for o23BFCzTrz.
Triplet Chemotherapy with Cisplatin versus Oxaliplatin in the CRITICS Trial: Treatment Compliance, Toxicity, Outcomes and Quality of Life in Patients with Resectable Gastric Cancer (2022)

(1) Background: Perioperative chemotherapy is the current standard treatment for patients with resectable gastric cancer. Based on studies in patients with metastatic gastric cancer, oxaliplatin has replaced cisplatin in the curative setting as well. However, evidence to prefer oxaliplatin over cisplatin in the curative setting is limited. (2) Methods: We compared patient-related and tumor-related outcomes for cisplatin versus oxaliplatin in patients with resectable gastric cancer treated with perioperative chemotherapy in the CRITICS trial. (3) Results: Preoperatively, 632 patients received cisplatin and 149 patients received oxaliplatin. Preoperative severe toxicity was encountered in 422 (67%) patients who received cisplatin versus 89 (60%) patients who received oxaliplatin (<i>p</i> = 0.105). Severe neuropathy was observed in 5 (1%) versus 6 (4%; <i>p</i> = 0.009) patients, respectively. Postoperative severe toxicity occurred in 109 (60%) versus 26 (51%) (<i>p</i> = 0.266) patients; severe neuropathy in 2 (1%) versus 2 (4%; <i>p</i> = 0.209) for patients who received cisplatin or oxaliplatin, respectively. Diarrhea impacted the quality of life more frequently in patients who received oxaliplatin compared to cisplatin. Complete or near-complete pathological response was achieved in 94 (21%) versus 16 (15%; <i>p</i> = 0.126) patients who received cisplatin or oxaliplatin, respectively. Overall survival was not significantly different in both groups (<i>p</i> = 0.300). (4) Conclusions: Both cisplatin and oxaliplatin are legitimate options as part of systemic treatment in patients with resectable gastric cancer.
ChemInform Abstract: NO‐Independent Stimulators of Soluble Guanylate Cyclase. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Arylalkylcarbenes from Triplet Arylalkyldiazoalkanes. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Compensation of Depleted Neuronal Subsets by New Neurons in a Local Area of the Adult Olfactory Bulb (2011)

In the olfactory bulb (OB), loss of preexisting granule cells (GCs) and incorporation of adult-born new GCs continues throughout life. GCs consist of distinct subsets. Here, we examined whether the loss and incorporation of GC subsets are coordinated in the OB. We classified GCs into mGluR2-expressing and -negative subsets and selectively ablated mGluR2-expressing GCs in a local area of the OB with immunotoxin-mediated cell ablation method. The density of mGluR2-expressing GCs showed considerable recovery within several weeks after the ablation. During recovery, an mGluR2-expressing new GC subset was preferentially incorporated over an mGluR2-negative new GC subset in the area of ablation, whereas the preferential incorporation was not observed in the intact area. The area-specific preferential incorporation of mGluR2-expressing new GCs occurred for BrdU analog- and retrovirus-labeled adult-born cells as well as for neonate-derived transplanted cells. The mGluR2-expressing new GCs in the ablated area were synaptically incorporated into the local bulbar circuit. The spine size of mGluR2-expressing new GCs in the ablated area was larger than that of those in the intact area. In contrast, mGluR2-negative new GCs did not show ablated area-specific spine enlargement. These results indicate that local OB areas have a mechanism to coordinate the loss and incorporation of GC subsets by compensatory incorporation of new GC subsets, which involves subset-specific cellular incorporation and subset-specific regulation of spine size.
Temporal Representation Learning on Monocular Videos for 3D Human Pose Estimation (2020)

In this paper we propose an unsupervised feature extraction method to capture temporal information on monocular videos, where we detect and encode subject of interest in each frame and leverage contrastive self-supervised (CSS) learning to extract rich latent vectors. Instead of simply treating the latent features of nearby frames as positive pairs and those of temporally-distant ones as negative pairs as in other CSS approaches, we explicitly disentangle each latent vector into a time-variant component and a time-invariant one. We then show that applying contrastive loss only to the time-variant features and encouraging a gradual transition on them between nearby and away frames while also reconstructing the input, extract rich temporal features, well-suited for human pose estimation. Our approach reduces error by about 50% compared to the standard CSS strategies, outperforms other unsupervised single-view methods and matches the performance of multi-view techniques. When 2D pose is available, our approach can extract even richer latent features and improve the 3D pose estimation accuracy, outperforming other state-of-the-art weakly supervised methods.
72.4: Invited Paper : Novel Approaches for OLED Lighting (2011)

Abstract In this paper, we discuss novel approaches for organic light‐emitting diode (OLED) lighting application. In particular, we discuss OLED deposited by vacuum deposition on flexible substrates such as plastic and metal foils. We discuss the specific challenges of OLED design for such substrates, in particular when top‐emitting structures are required. Furthermore, we discuss a novel vacuum roll‐to‐roll tool which is capable of depositing oligomer OLED with high efficiency.
The IMMUTANS Variegation Locus of Arabidopsis Defines a Mitochondrial Alternative Oxidase Homolog That Functions during Early Chloroplast Biogenesis (1999)

Nuclear gene-induced variegation mutants provide a powerful system to dissect interactions between the genetic systems of the nucleus-cytoplasm, the chloroplast, and the mitochondrion. The immutans (im) variegation mutation of Arabidopsis is nuclear and recessive and results in the production of green- and white-sectored leaves. The green sectors contain cells with normal chloroplasts, whereas the white sectors are heteroplastidic and contain cells with abnormal, pigment-deficient plastids as well as some normal chloroplasts. White sector formation can be promoted by enhanced light intensities, but sectoring becomes irreversible early in leaf development. The white sectors accumulate the carotenoid precursor phytoene. We have positionally cloned IM and found that the gene encodes a 40.5-kD protein with sequence motifs characteristic of alternative oxidase, a mitochondrial protein that functions as a terminal oxidase in the respiratory chains of all plants. However, phylogenetic analyses revealed that the IM protein is only distantly related to these other alternative oxidases, suggesting that IM is a novel member of this protein class. We sequenced three alleles of im, and all are predicted to be null. Our data suggest a model of variegation in which the IM protein functions early in chloroplast biogenesis as a component of a redox chain responsible for phytoene desaturation but that a redundant electron transfer function is capable of compensating for IM activity in some plastids and cells.
Decoded Calreticulin-Deficient Embryonic Stem Cell Transcriptome Resolves Latent Cardiophenotype (2010)

Genomic perturbations that challenge normal signaling at the pluripotent stage may trigger unforeseen ontogenic aberrancies. Anticipatory systems biology identification of transcriptome landscapes that underlie latent phenotypes would offer molecular diagnosis before the onset of symptoms. The purpose of this study was to assess the impact of calreticulin-deficient embryonic stem cell transcriptomes on molecular functions and physiological systems. Bioinformatic surveillance of calreticulin-null stem cells, a monogenic insult model, diagnosed a disruption in transcriptome dynamics, which re-prioritized essential cellular functions. Calreticulin-calibrated signaling axes were uncovered, and network-wide cartography of undifferentiated stem cell transcripts suggested cardiac manifestations. Calreticulin-deficient stem cell-derived cardiac cells verified disorganized sarcomerogenesis, mitochondrial paucity, and cytoarchitectural aberrations to validate calreticulin-dependent network forecasts. Furthermore, magnetic resonance imaging and histopathology detected a ventricular septal defect, revealing organogenic manifestation of calreticulin deletion. Thus, bioinformatic deciphering of a primordial calreticulin-deficient transcriptome decoded at the pluripotent stem cell stage a reconfigured multifunctional molecular registry to anticipate predifferentiation susceptibility toward abnormal cardiophenotype.
Multiplexing Statistical Real-Time Channels in a Multiaccess Local-Area Network. (1996)

VIP and PACAP38 are closely related peptides that are released in the adrenal gland and sympathetic ganglia and regulate catecholamine synthesis and release. We used PC12 cells as a model system to examine receptor and second messenger pathways by which each peptide stimulates transcriptional and post-transcriptional mechanisms that regulate the level of the mRNA for tyrosine hydroxylase (TH), the rate-limiting enzymatic step in catecholamine synthesis. Concentration-response studies revealed that PACAP38 had both greater efficacy and potency than VIP. The specific PAC1 receptor antagonist PACAP[6-38] blocked the effects of each peptide on TH mRNA content while the PACAP/VIP type II receptor antagonist (N-AC-Tyr(1)-D-Phe(2))-GRF-(1-29)-NH(2) was without effect. At equipotent concentrations, each peptide stimulated a transient increase in TH gene transcription lasting less than 3h. Continuous VIP treatment stimulated a transient increase in TH mRNA lasting less than 24h. In contrast, continuous exposure to PACAP38 stimulated a stable increase in TH mRNA that persisted for 2 days in the absence of elevated transcription, pointing to different post-transcriptional effects of the two peptides. PACAP38 alone had no effect on the magnitude of TH gene transcription or TH mRNA in A126-1B2 PKA-deficient PC12 cells. However, when combined with dexamethasone, PACAP38 produced a synergistic increase in TH mRNA in the absence of PACAP38-stimulated TH gene transcription. In contrast, VIP had no effect on either TH mRNA content or TH gene transcription in this model. PACAP38, but not VIP, stimulated PKC activity. Calphostin C antagonized the effect of PACAP38 on the persistent post-transcriptional elevation in TH mRNA. Thus, the results support the conclusion that VIP and PACAP38 each stimulate PAC1 receptors to increase TH gene transcription through a PKA-controlled pathway, but their divergent post-transcriptional effects result at least partly from differing abilities to stimulate PKC.
Scrape-Loading Assisted Intracellular Delivery via Microconstriction Featuring A Sharp Edge (2016)

A novel structure of micro-constriction featuring sharp edges is demonstrated here for intracellular delivery of macromolecules. The constriction allows for a high average cell-passing speed of 2.5 m/s under a significantly reduced pressure applied at 1 bar. Macromolecule-delivery-efficiency of 52.6% and cell-viability of 80% are achieved using the structures at this low pressure.
A Conserved Downstream Element Defines a New Class of RNA Polymerase II Promoters (1995)

Although many TATA-less promoters transcribed by RNA polymerase II initiate transcription at multiple sites, the regulation of multiple start site utilization is not understood. Beginning with the prediction that multiple start site promoters may share regulatory features and using the P-glycoprotein promoter (which can utilize either a single or multiple transcription start site(s)) as a model, several promoters with analogous transcription windows were grouped and searched for the presence of a common DNA element. A downstream protein-binding sequence, MED-1 (Multiple start site Element Downstream), was found in the majority of promoters analyzed. Mutation of this element within the P-glycoprotein promoter reduced transcription by selectively decreasing utilization of downstream start sites. We propose that a new class of RNA polymerase II promoters, those that can utilize a distinctive window of multiple start sites, is defined by the presence of a downstream MED-1 element.
100-GHz and 300-GHz coherent radio-over-fiber transmission using optical frequency comb source (2013)

Millimeter-wave and sub-millimeter-wave radio-over-fiber (RoF) technology with digital-signal-processing­ aided coherent detection can be a promising candidate for high-speed radio transmission links with a capacity of greater than 10 Gb/s if the energy consumption does not increase drastically. We demonstrate 100-GHz­ and 300-GHz-band simultaneous RoF signal generation using an optical frequency comb source comprising an optical frequency shifter in an amplified optical fiber loop, and its radio transmission over the air. 10-Gbaud quadrature-phase-shift-keying provides a capacity of 18.6 Gb /s with a 7% forward error correction overhead in single carrier signal transmission as well as in multi-carrier transmission.
Gouverner la métropole parisienne (2020)

Chaotiquement, une métropole parisienne est en train d’émerger. C’est ce que démontrent les auteurs de cet ouvrage, en relisant l’histoire de la gouvernance de ce territoire, prise en tension entre la volonté de l’État de contrôler la capitale à coup de plans stratégiques et d’organisations, et l’établissement de coopérations horizontales respectant la vieille opposition entre Paris et sa banlieue. Avec le temps, ces deux logiques ont perdu de leur force. La décentralisation a rebattu les cartes au sein de l’Île-de- France. Les politiques publiques menées dans les domaines des transports, de la police ou de la rénovation urbaine ont fait bouger les anciennes lignes de structuration et d’opposition politique. La toute-puissance de Paris, symboliquement défendue par le boulevard périphérique, s’est estompée sous l’action des réseaux, des institutions et même des conflits. Nourrie de recherches originales, cette analyse documentée éclaire avec précision les dynamiques politiques et institutionnelles d’une métropolisation inachevée.
Nnon-collaborative interest mining for personal devices (2009)

In our daily life we frequently use mobile devices to interact with the people and things on the Internet. However, finding the right things when needed is getting difficult and frustrating. In this paper, we introduce a relatively new problem of non-collaborative personal interest mining using contexts and ratings available for items of interest. We present multi-step algorithms to extract personal situational interests from mobile phone usage logs without depending on other people's data. The algorithms are based on clustering or a direct analogy from collaborative filtering. We provide extensive experimental results with our accuracy measure for synthetic data sets. The main advantages of our algorithms are: 1) no need for the user to train the phone actively, 2) no need for prior knowledge of the situations contained in a data set, 3) light-weight and running completely on a personal mobile phone and 4) good performance over low data densities. We also present a SmartSearch application. Upon user request, it automatically constructs search queries based on learned user interests and obtains information and advertisements for the user that suit the user's situation.
Synergistic Composite Coating for Separators in Lithium Metal Batteries (2021)

Despite their conspicuous advantages in energy density, lithium metal batteries (LMBs) are still in the research stage owing to uncontrolled lithium dendrite growth, which deteriorates their cycle life and safety. In this study, we aim to formulate a separator coating and identify the optimal coating conditions that are scalable with the ultimate goal of fabricating separators that largely address the chronic issues of LMBs. For this purpose, a mixture of an ionic liquid, a block copolymer, and microspheres was applied to a conventional polyethylene separator. While the polymeric microspheres mechanically strengthen the coating layer against lithium dendrite growth, the ionic liquid and block copolymer support lithium ion conduction and provide robust connections among the composite components, all jointly resulting in a uniform lithium ion flux, which in turn results in plated lithium metal with a highly compact morphology. Alongside improved thermal stability, this composite coating enables superior cyclability in Li||Li symmetric and Li||Cu asymmetric cells as well as pouch-type full cells. The simple, scalable nature of the present coating approach renders it useful not only for lithium metal batteries currently in development but also for common commercial lithium ion batteries, which suffer from severe lithium plating upon fast charging.
Novel hydrogen chemisorption properties of amorphous ceramic compounds consisting of p-block elements: exploring Lewis acid–base Al–N pair sites formedin situwithin polymer-derived silicon–aluminum–nitrogen-based systems (2020)

This paper reports the relationship between the H<sub>2</sub>chemisorption properties and reversible structural reorientation of the possible active sites around Al formed<italic>in situ</italic>within polymer-derived ceramics (PDCs) based on an amorphous Si–Al–N system.
A Green Fluorescent Protein with Photoswitchable Emission from the Deep Sea (2008)

A colorful variety of fluorescent proteins (FPs) from marine invertebrates are utilized as genetically encoded markers for live cell imaging. The increased demand for advanced imaging techniques drives a continuous search for FPs with new and improved properties. Many useful FPs have been isolated from species adapted to sun-flooded habitats such as tropical coral reefs. It has yet remained unknown if species expressing green fluorescent protein (GFP)-like proteins also exist in the darkness of the deep sea. Using a submarine-based and -operated fluorescence detection system in the Gulf of Mexico, we discovered ceriantharians emitting bright green fluorescence in depths between 500 and 600 m and identified a GFP, named cerFP505, with bright fluorescence emission peaking at 505 nm. Spectroscopic studies showed that approximately 15% of the protein bulk feature reversible ON/OFF photoswitching that can be induced by alternating irradiation with blue und near-UV light. Despite being derived from an animal adapted to essentially complete darkness and low temperatures, cerFP505 maturation in living mammalian cells at 37 degrees C, its brightness and photostability are comparable to those of EGFP and cmFP512 from shallow water species. Therefore, our findings disclose the deep sea as a potential source of GFP-like molecular marker proteins.
XPO1 target occupancy measurements confirm the selinexor recommended phase 2 dose (2017)

// Marsha L. Crochiere 1 , Stefan Hannus 2 , Kerrin Hansen 2 , Frank Becker 2 , Erkan Baloglu 1 , Margaret Lee 1 , Michael Kauffman 1 , Sharon Shacham 1 and Yosef Landesman 1 1 Karyopharm Therapeutics, Inc, Newton, MA 02459, USA 2 Intana Bioscience GmbH, D-82152 Planegg/Martinsried, Munich, Germany Correspondence to: Marsha L. Crochiere, email: mcrochiere@karyopharm.com Keywords: selinexor; export; occupancy; cancer; dose Received: September 08, 2017&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Accepted: November 09, 2017&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Published: November 30, 2017 ABSTRACT XPO1 (exportin 1) is the main nuclear export protein with over 200 different protein cargos. XPO1 is overexpressed in tumor cells and high levels are correlated with poor prognosis. Selective Inhibitor of Nuclear Export (SINE) compounds block nuclear export by inhibiting XPO1. The first SINE compound, selinexor, shows promising anti-cancer activity across hematological and solid tumors in Phase 2 and 3 clinical trials. The 2 nd generation SINE compound KPT-8602 is being evaluated as an anti-cancer agent in a Phase 1 clinical trial. To predict patient response to treatment and confirm the selinexor recommended phase 2 dose (RP2D), an assay based on fluorescence cross correlation spectroscopy that measures XPO1 occupancy in cancer cells was developed. Studies comparing cytotoxicity and XPO1 occupancy in cell lines treated with selinexor or KPT-8602 indicated that XPO1 occupancy by both compounds could reach saturation regardless of drug sensitivity. However, higher levels of XPO1 protein correlated with lower sensitivity to SINE compound cytotoxicity. In vivo mouse studies showed XPO1 occupancy could be measured in tumors and was dose-dependent, with &gt;90% target saturation at 10 mg/kg (~50 mg flat dose in humans). Drug-target occupancy was measured in a dose-response time course and full occupancy occurred by 6 hours at all doses. The duration of occupancy was dose-dependent, where 10-15 mg/kg in mice (~ 50-75 mg human flat dose) was necessary to maintain XPO1 occupancy up to 48 hours post-dose. These findings confirm the selinexor RP2D of 60 mg for achieving target occupancy and inhibition up to 48 hours.
Maximum likelihood detection for single carrier &#x2014; FDMA: Performance analysis (2010)

Tight performance bounds are derived for maximum likelihood detection of uncoded SC-FDMA transmission over the Rayleigh fading channel. Closed-form expressions are provided for approximating the lower bound on the BER performance in the high and low SNR regimes. The derived bounds are validated by simulation.