gebhart/patrepeval huggingface dataset:
Neoadjuvant cisplatin-based chemotherapy in patients with ureteral obstruction secondary to muscle invasive bladder cancer. (2020)

523 Background: Neoadjuvant cisplatin-based chemotherapy (NAC) followed by cystectomy is the standard of care for muscle-invasive urothelial bladder cancer (MIBC). 15-35% of MIBC patients present with ureteral obstruction. Poor renal function increases cisplatin toxicity. It is unknown whether patients with ureteral obstruction which has been relieved (whether by nephrostomy tube or nephroureteral stent) have the same risk of toxicity as patients without ureteral obstruction. Methods: We retrospectively reviewed an institutional database of all patients undergoing NAC for MIBC with either dose dense MVAC (ddMVAC) or gemcitabine and cisplatin (GC) from January 2004 through May 2017. Patients without ureteral obstruction prior to initiation of NAC (Group A) were compared to those who had ureteral obstruction which was relieved prior to undergoing NAC (Group B). Continuous variables were compared using the Wilcoxon rank-sum test and categorical variables were compared using Fisher’s exact test. The primary outcome was premature discontinuation of NAC, which was defined as failure to complete all planned cycles. Logistic regression was used to test for differences between the groups in this outcome adjusting for age, ECOG performance status, and baseline glomerular filtration rate (GFR). Results: 160 patients in Group A and 59 patients in Group B were identified. Baseline age, Charlson Comorbidity Index, race, smoking status, and ECOG performance status were similar. Patients in Group B had lower GFR (99.2% vs 78.8% p &lt;0.001) and were more likely to be female (21.9% vs 27.3% p &lt;0.025) and to receive ddMVAC (65.0% vs. 83.1% p =0.012). There was no significant difference between groups in rates of premature NAC discontinuation (15.8% vs 22.0% p = 0.284) or grade ≥3 adverse events (23.4% vs 30.5% p = 0.285). Adjusted analysis showed no significant difference between the groups in frequency of premature NAC discontinuation (OR 1.96, 95% CI 0.84-4.57 p=0.12). Conclusions: We detected no difference in frequency of premature discontinuation of NAC in patients with relieved malignant ureteral obstruction relative to patients without obstruction. NAC for MIBC is likely safe in this population.
Generalized hashing and applications to digital fingerprinting (2003)

Let C be a code of length n over an alphabet of q letters. An n-word y is called a descendant of a set of t codewords x/sup 1/, ..., x/sup t/ if yi /spl isin/ {x/sub i//sup 1/, ..., x/sub i//sup t/} for all i=1, ..., n. A code is said to have the t-identifying parent property if for any n-word that is a descendant of at most t parents it is possible to identify at least one of them. We study a generalization of hashing, (t, u)-hashing, which ensures identification, and provide tight estimates of the rates.
Biological activities of deoxyspergualin in autoimmune disease mice. (1988)

An assessment of the prophylactic and ameliorative effects of deoxyspergualin (NKT-01), an immunosuppressive agent, was carried out in male MRL/MpJ-lpr/lpr (MRL/1) mice which spontaneously develop lupus-like lesions. When NKT-01 was administered ip daily from the age of either 8 or 19 weeks, diseases such as massive lymphadenopathy, circulating anti-DNA antibody and lupus nephritis were markedly suppressed. The primary response to lipopolysaccharide was significantly reduced in MRL/1 mice administered NKT-01 but the response to sheep red blood cells was not affected. The ability of spleen cells to release interleukins 2 and 3 with or without mitogen was significantly enhanced in mice receiving NKT-01. These findings demonstrate that NKT-01 has therapeutic activity against the development of spontaneous disease in MRL/1 mice.
A measurement-based admission control algorithm for integrated services packet networks (1995)

Many designs for integrated service networks offer a bounded delay packet delivery service to support real-time applications. To provide bounded delay service, networks must use admission control to regulate their load. Previous work on admission control mainly focused on algorithms that compute the worst case theoretical queueing delay to guarantee an absolute delay bound for all packets. In this paper we describe a measurement-based admission control algorithm for predictive service, which allows occasional delay violations. We have tested our algorithm through simulations on a wide variety of network topologies and driven with various source models, including some that exhibit long-range dependence, both in themselves and in their aggregation. Our simulation results suggest that, at least for the scenarios studied here, the measurement-based approach combined with the relaxed service commitment of predictive service enables us to achieve a high level of network utilization while still reliably meeting the delay bound.
Data from Targeted Anti–Vascular Endothelial Growth Factor Receptor-2 Therapy Leads to Short-term and Long-term Impairment of Vascular Function and Increase in Tumor Hypoxia (2023)

&lt;div&gt;Abstract&lt;p&gt;Because antiangiogenic therapies inhibit the growth of new tumor-associated blood vessels, as well as prune newly formed vasculature, they would be expected to reduce the supply of oxygen and thus increase tumor hypoxia. However, it is not clear if antiangiogenic treatments lead only to consistent and sustained increases in hypoxia, or transient decreases in tumor hypoxia along with periods of increased hypoxia. We undertook a detailed analysis of an orthotopically transplanted human breast carcinoma (MDA-MB-231) over a 3-week treatment period using DC101, an anti–vascular endothelial growth factor receptor 2 antibody. We observed consistent reductions in microvascular density, blood flow (measured by high-frequency micro-ultrasound), and perfusion. These effects resulted in an increase in the hypoxic tumor fraction, measured with an exogenous marker, pimonidazole, concurrent with an elevation in hypoxia-inducible factor-1α expression, an endogenous marker. The increase in tumor hypoxia was evident within 5 days and remained so throughout the entire course of treatment. Vascular perfusion and flow were impaired at days 2, 5, 7, 8, 14, and 21 after the first injection, but not at 4 hours. A modest increase in the vessel maturation index was detected after the 3-week treatment period, but this was not accompanied by an improvement in vascular function. These results suggest that sustained hypoxia and impairment of vascular function can be two consistent consequences of antiangiogenic drug treatment. The implications of the results are discussed, particularly with respect to how they relate to different theories for the counterintuitive chemosensitizing effects of antiangiogenic drugs, even when hypoxia is increased. (Cancer Res 2006; 66(7): 3639-48)&lt;/p&gt;&lt;/div&gt;
Asymmetric aldol reaction between achiral silyl enol ethers and achiral aldehydes by use of a chiral promoter system (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric aldol reaction between achiral silyl enol ethers and achiral aldehydes by use of a chiral promoter systemShu Kobayashi, Hiromi Uchiro, Yuko Fujishita, Isamu Shiina, and Teruaki MukaiyamaCite this: J. Am. Chem. Soc. 1991, 113, 11, 4247–4252Publication Date (Print):May 1, 1991Publication History Published online1 May 2002Published inissue 1 May 1991https://pubs.acs.org/doi/10.1021/ja00011a030https://doi.org/10.1021/ja00011a030research-articleACS PublicationsRequest reuse permissionsArticle Views2309Altmetric-Citations208LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: SAR Studies of Novel 5‐Substituted 2‐Arylindoles as Nonpeptidyl GnRH Receptor Antagonists. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Transparent Network Memory Storage for Efficient Container Execution in Big Data Clouds (2021)

This paper presents a transparent Container Network Memory storage device, coined as CNetMem, aiming to address the open problem of unpredictable performance degradation of containers when the working set of an application no longer fits in container memory. First, CNetMem will enable application tenants running in a container to park their working set memory/file to a faster network memory storage by organizing a group of remote memory nodes as remote memory donors. This allows CNetMem to take advantage of remote idle memory on a cluster before resorting to a slow local I/O subsystem like local disk without any modification of host OS or application. Second, CNetMem provides a hybrid batching technique to remove or alleviate performance bottlenecks in the I/O performance critical path for remote memory read/write with replication or disk backup for fault tolerance. Third, CNetMem introduces a rank-based node selection algorithm to find the optimal node for placing remote memory blocks across cluster. This helps CNetMem to reduce the performance impact due to remote memory eviction. Extensive experiments are conducted on three big data applications and four machine learning workloads. The results show that CNetMem achieves up to 172× throughput improvements compared to vanilla Linux and up to 5.9× completion time improvements over existing approaches in big data and ML workload.
Einfluss der Düsengeometrie auf die Partikelbildung bei der Entspannung überhitzter Suspensionen (2002)

No translation.
Improvement of Saccharification of Empty Fruit Bunch and Japanese Cedar Pulps with an Amphiphilic Lignin Derivative (2010)

日本および東南アジアで多量排出されるスギ間伐材やオイルパームの空果房（EFB）から酵素糖化を経てバイオエタノールなどのプラットフォーム化合物を製造することを想定して，本研究では，酵素糖化助剤となる両親媒性リグニン誘導体を開発し，スギおよびEFBの糖化に対する効果を検討した。酵素糖化のための前処理として，スギにはアルカリパルプ化，EFBにはクラフトパルプ化を行い，残存リグニン量約11％のスギパルプ，および残存リグニン量10％と12％のEFBパルプに対し糖化を行った。これらのパルプのセルラーゼ処理時に，リグニン誘導体を添加すると糖化率，特にEFBパルプに対し向上し，処理後も有意なセルラーゼ活性が検出された。
Picard's method to solve a system of biaffine equations and its application to pole placement (2013)

Picard's method for finding the roots of univariate polynomials has been extended to solve multivariate biaffine equations. It is shown that from the same initial guess, the proposed method finds most of the real solutions of a set of biaffine equations. Method's applicability in solving constrained state and output feedback pole placement problems is demonstrated through numerical examples. The main advantage of this method is that it provides a systematic way of finding more than one solutions of a given set of equations.
Dimethylacetamide sorption kinetics in a urethane/urea/ether block copolymer (1994)

Abstract Polymer solvent interactions in a block polyurethane/urea/ether polymer belonging to the spandex family are considered in this article. Independent analysis of the sorption isotherms for dimethylacetamide (DMAc) in the spandex spandex polymer as a function of vapor activity and temperature were presented in a previous article. A second aspect in understanding solvent/polymer interactions is the kinetics of desorption. Characterization of the solvent devolatilization is an important aspect of the drying procedure to guide processing protocols to eliminate residual solvent in the final spandex products, especially for medical applications [E. Hicks, A. Ultee, and J. Drougas, Science , 147 , 373 (1965); J. W. Boretos and W. S. Pierce, J. Biomed. Mater. Res ., 2 , 121 (1968); P. M. Knight and D. J. Lyman, J. Membr. Sci ., 17 , 245 (1984)]. This article reports data for desorption kinetics under nominally isothermal conditions to provide diffusion coefficients as a function of polymer phase concentration and temperature. Desorption curves were found to be Fickian at least up to the half‐time of desorption. Diffusion coefficients were therefore calculated using a half‐time method. Temperature effects upon sorption or desorption were measured to obtain corrected diffusion coefficients and found to be singificantly different than the apparent diffusion coefficient measured from a conventional McBain sorption cell. © 1994 John Wiley &amp; Sons, Inc.
JNK1 as a Molecular Target To Limit Cellular Mortality under Hypoxia (2006)

Many pathological conditions and environmental impacts lead to a decrease in tissue oxygen supply and severe cellular hypoxia. This secondary hypoxia can disturb cellular homeostasis, limiting the efficacy of the prescribed treatment for the primary lesion, eventually leading to cellular and organismal death. Jun N-terminal kinase 1 (JNK1) plays a major role in the hypoxic cellular damage. Therefore, we hypothesized that suppression of JNK1 activity will decrease cellular mortality under hypoxia and might increase the efficacy of traditional treatment of many pathological conditions. These investigations are aimed at studying the influence of the suppression of JNK1 activity on the development of cellular hypoxic damage. We used antisense oligonucleotides (ASO) and small interfering RNA (siRNA) targeted to JNK1 mRNA to inhibit the protein synthesis. Experiments were carried out on a cell culture under normoxia and hypoxic conditions that led to the death of approximately 50% of cells. ASO or siRNA was delivered by neutral or cationic liposomes. Intracellular localization of ASO and liposomes and mechanisms of apoptosis were studied. We found that the suppression of JNK1 activity by liposomal antisense oligonucleotides or siRNA limits the caspase-dependent apoptosis signaling pathway and decreases cellular mortality after severe hypoxia. JNK1 protein might be an attractive target for antihypoxic therapy in increasing resistance to many pathological conditions and diseases, leading to the oxygen deficit.
Boronic acid based photoinduced electron transfer (PET) fluorescence sensors for saccharides (2010)

A simple three step synthesis was developed to provide six novel modular sensors, consisting of three para sensors, and three meta sensors with naphthalene, anthracene and pyrene fluorophores. The interaction of the six sensors with the saccharides: D-glucose, D-fructose, D-galactose, and D-mannose, were evaluated. All sensors displayed increasing fluorescence intensity upon the addition of these saccharides, with all of the sensors showing enhanced selectivity for D-glucose over D-galactose, D-fructose and D-mannose. High affinity (Kobs) was also observed for the meta sensors with respect to the para sensors. The naphthalene and anthracene meta sensors showed particularly high affinity (Kobs) for D-galactose. Circular dichroism spectroscopy was used to probe the structures of the complexes formed. Cyclic complexes were formed between all six sensors and D-glucose. Whilst naphthalene and anthracene meta sensors which displayed high affinity for D-galactose also formed cyclic complexes with that saccharide.
A 2-Helix Small Protein Labeled with 68Ga for PET Imaging of HER2 Expression (2009)

This proof-of-concept research clearly demonstrated that synthetic 2-helix (68)Ga-DOTA-MUT-DS is a promising PET probe for imaging HER2 expression in vivo. The Affibody-derived small 2-helix protein scaffold has great potential for developing targeting agents for a variety of tumor-associated biomarkers.
Increased 3′‐Phosphoadenosine‐5′‐phosphosulfate Levels in Engineered Escherichia coli Cell Lysate Facilitate the In Vitro Synthesis of Chondroitin Sulfate A (2019)

Chondroitin sulfates (CSs) are linear glycosaminoglycans that have important applications in the medical and food industries. Engineering bacteria for the microbial production of CS will facilitate a one-step, scalable production with good control over sulfation levels and positions in contrast to extraction from animal sources. To achieve this goal, Escherichia coli (E. coli) is engineered in this study using traditional metabolic engineering approaches to accumulate 3'-phosphoadenosine-5'-phosphosulfate (PAPS), the universal sulfate donor. PAPS is one of the least-explored components required for the biosynthesis of CS. The resulting engineered E. coli strain shows an ≈1000-fold increase in intracellular PAPS concentrations. This study also reports, for the first time, in vitro biotransformation of CS using PAPS, chondroitin, and chondroitin-4-sulfotransferase (C4ST), all synthesized from different engineered E. coli strains. A 10.4-fold increase is observed in the amount of CS produced by biotransformation by employing PAPS from the engineered PAPS-accumulating strain. The data from the biotransformation experiments also help evaluate the reaction components that need improved production to achieve a one-step microbial synthesis of CS. This will provide a new platform to produce CS.
A New Concept of Bioartificial Liver Based on a Fluidized Bed Bioreactor (1999)

Many bioartificial livers have been developed, but most of them suffer from difficulty when being scaled up and from poor efficiency of mass transfer between the plasma and the immobilized hepatocytes. We present a new concept of bioartificial liver based on the fluidized bed motion of hepatocytes entrapped in alginate beads. The bioreactor is designed to offer stable behavior. The maximum fluid perfusion velocity is determined to avoid any bead release from the bioreactor. The fluidized bed height depends on the amount of beads and the velocity employed. Under the optimized operating conditions, the mass transfer between perfusion fluid and beads is very efficient; only 10 min are necessary to reach concentration equilibrium. Hence, this fluidized bed bioartificial liver appears to be a promising tool for a liver support system in the treatment of acute liver failure.
Observing Single, Heterogeneous, One-Electron Transfer Reactions (2015)

Understanding electrochemical events on the single-molecule level is crucial for fields such as catalysis and biological systems. A variety of techniques exist to study the electrochemistry of single molecules, but few provide correlated chemical information. Herein, we study the electrochemistry of rhodamine 6G in nonaqueous conditions and demonstrate the first statistic electrochemical single-molecule SERS (EC-SMSERS) proof of single-electron transfer events. We find that the distribution of reduction events is broader than that in a bulk electrochemical experiment. The distribution of the reduction potentials can be explained by molecular reorientation and variations of the local surface site or chemical potential of the Ag nanoparticle. Our results contribute toward understanding electrochemical behavior of single molecules on the nanoscale monitored by SERS and the ultimate goal of controlling single-electron transfer processes.
New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice (2019)

In order to provide new insights into the various activities of GH in specific tissues, recent advances have allowed for the generation of tissue-specific GHR knockout mice. To date, 21 distinct tissue-specific mouse lines have been created and reported in 28 publications. Targeted tissues include liver, muscle, fat, brain, bone, heart, intestine, macrophage, pancreatic beta cells, hematopoietic stem cells, and multi-tissue "global". In this review, we provide a brief history and description of the 21 tissue-specific GHR knockout mouse lines. Arch Endocrinol Metab. 2019;63(6):557-67.
Influenza Virus Surveillance in Waterfowl in Pennsylvania after the H5N2 Avian Outbreak (1986)

V. S. Hinshaw, V. F. Nettles, L. F. Schorr, J. M. Wood, R. G. Webster, Influenza Virus Surveillance in Waterfowl in Pennsylvania after the H5N2 Avian Outbreak, Avian Diseases, Vol. 30, No. 1 (Jan. - Mar., 1986), pp. 207-212
High Quantum Efficiency Blue Phosphorescent Organic Light-Emitting Diodes Using 6-Position-Modified Benzofuro[2,3-b]pyridine Derivatives (2013)

High quantum efficiency blue phosphorescent organic light-emitting diodes were developed using 6- position modified benzofuro[2,3-b]pyridine derivatives as host materials. Two high triplet energy host materials derived from benzofuro[2,3-b]pyridine modified with carbazole or 9-phenylcarbazole were synthesized and the device performances of the host materials were investigated. A high quantum efficiency of 24.3% was achieved using the benzofuro[2,3-b]pyridine host materials due to good charge balance and energy transfer.
Inpainting Highlights Using Color Line Projection (2007)

In this paper we propose a novel method to inpaint highlights and to remove the specularity in the image with specular objects by the color line projection. Color line projection is the method that a color with a surface reflection component is projected near the diffuse color line by following the direction of the specular color line. We use two captured images using different exposure time so that the clue of the original color in a highlight area is searched from two images since the color at the highlight region is distorted and saturated to the illumination color. In the first step of the proposed procedure, the region corresponding to the highlight is generated and the clue of the original highlight color is acquired. In the next step, the color line is generated by the restricted region growing method around the highlight region, and the color line is divided into the diffuse color line and the specular color line. In the final step, pixels near the specular color line are projected onto near the diffuse color line by the color line projection, in which the modified random function is applied to realistically inpaint the highlight. One of advantages in our method is to find the highlight region and the clue of the original color of the highlight with ease. It also efficiently estimates the surface reflection component which is utilized to remove specularity and to inpaint the highlight. The proposed method performs the highlight inpainting and the specular removal simultaneously once the color line is generated. In addition, color line projection with the modified random function can make the result more realistic. We show experimental results from the real images and make a synthesis of the real image and the image modified by the proposed method.
Optimization of rapid acquisition with relaxation enhancement (RARE) pulse sequence parameters for 19F‐MRI studies (2013)

Optimal settings according to measured relaxation times can significantly improve the sensitivity threshold in ¹⁹F MRI studies. They were provided in a wide range of (T₁, T₂) values and experimentally validated showing good agreement.
Software fault detection in control systems (2016)

Fault detection in the software of control systems is a difficult task. In largely interconnected systems, not only the individual performance of one channel, but also its interaction with other co ...