gebhart/patrepeval huggingface dataset:
Global content revocation on the internet (2022)

Common wisdom holds that once personal content such as photographs have been shared on the Internet, they will stay there forever. This paper explores how we could allow users to reclaim some degree of their privacy by "revoking" previously shared photographs, hindering (but not eliminating) any subsequent viewing or sharing by others. Our goal is not to build a system that can withstand determined efforts to subvert it, but rather to give well-intentioned users the ability to respect the privacy wishes of others. Achieving this goal at scale will eventually require the participation of large content aggregators, and they are unlikely (putting it mildly) to find our proposal compelling. We therefore propose an approach we call technology ecosystem transformation (TET) that begins with a transitional and more easily deployable (but not fully scalable) design that does not require the participation of large incumbents but is designed to change user and societal expectations enough so that these companies would find it in their interest to adopt the approach we propose here. The intellectual challenge in this TET approach is finding transitional designs that (i) have parties willing to deploy it and (ii) once deployed, would change the incentives for the incumbents so that they would be willing to adopt the proposal.
Supplementary Figure 6B from Molecular Triage of Premalignant Lesions in Liquid-Based Cervical Cytology and Circulating Cell-Free DNA from Urine, Using a Panel of Methylated Human Papilloma Virus and Host Genes (2023)

&lt;p&gt;Scatter plots of HPV 16-L1 methylation in cervical brush (S7a) and urine ccfDNA (S7b). HPV16-L1 qMSP methylation can discriminate bisulfite treated cervical epithelium DNA and urine ccfDNA from patients with normal cytology, from women with dysplastic cytology, and premalignant cervical lesions with high Sensitivity and Specificity.&lt;/p&gt;
IL-10/Fc INHIBITS MACROPHAGE FUNCTION AND PROLONGS PANCREATIC ISLET XENOGRAFT SURVIVAL1 (1999)

IL-10/Fc prolonged rat pancreatic islet xenograft survival by inhibiting macrophage mediated immune responses. The effectiveness of this agent when administered pretransplant suggests it may have a role as an induction agent with potential clinical application.
RNAs of influenza A, B, and C viruses (1976)

The nucleic acids of influenza A, B, and C viruses were compared. Susceptibility to nucleases demonstrates that influenza C virus, just as influenza A and B viruses, possesses single-stranded RNA as its genome. The base compositions of the RNAs of influenza A, B, and influenza C virus are almost identical and comparative analysis on polyacrylamide gels shows that the genome of influenza C/GL/1167/54 virus, like that of the RNAs of influenza A and B viruses, is segmented. Eight distinct RNA bands were found for influenza A/PR/8/34 virus and for influenza B/Lee/40 virus. The RNA of influenza C/GL/1167/54 virus separated into at least four segments. The total molecular weights of the RNA of influenza A/PR/8/34 and B/Lee/40 virus were calculated to be 5.29 X 10(6) and 6.43 X 10(6), respectively. A minimum value of 4.67 X 10(6) daltons was obtained for influenza C/GL/1167/54 virus RNA. The data suggest that influenza C viruses are true members of the influenza virus group.
Injection system for microtron-based terehertz FEL (2005)

A reliable injection system of the widely tunable microtron-based terahertz Free Electron Laser (FEL) has been developed and during last few years provides stable operation of the FEL for users. The system is based on the long-life thermionic cathode assembly using 2.5 mm-in diameter monocrystalline LaB{sub 6} emitter, heated by the tungsten cylindrical filament with the power consumption less than 55 W. The cathode emits the macro-pulse current in the range of 1-1.4 A providing operation of the terahertz FEL during more than 1000 h. The cathode assembly is installed on the cover of the I-type microtron accelerating cavity in location providing an efficient injection for the acceleration with variable number of orbits. This variation widely changes the energy of the electron beam and allows on-the-fly retuning of the FEL in the range of 1-3 THz. Pulse-signal system stabilizing the emission current prevents randomized break-downs in the accelerating cavity and decreases fluctuations of the power of the FEL radiation. The standard deviation of the fluctuations was measured to be less than 10% during long-time operation.
Differential Sensitivity to Block by Class III Antiarrhythmic Agents (1990)

An envelope of tails test was used to show that the delayed rectifier K § current (Iv.) of guinea pig ventricular myocytes results from the activation of two outward K § currents. One current was specifically blocked by the benzenesulfon- amide antiarrhythmic agent, E-4031 (IC50 = 397 nM). The drug-sensitive current, exhibits prominent rectification and activates very rapidly relative to the slowly activating drug-insensitive current, Ivs. Iv, was characterized by a delayed onset of activation that occurs over a voltage range typical of the classically described cardiac I K. Fully activated Ivs, measured as tail current after 7.5-s test pulses, was 11.4 times larger than the fully activated I~. Ig r was also blocked by d-sotalol (100 #M), a less potent benzenesulfonamide Class III antiarrhythmic agent. The activation curve of lv~ had a steep slope (+7.5 mV) and a negative half-point (-21.5 mV) relative to the activation curve of Ivs (slope = + 12.7 mV, half-point = + 15.7 mV). The reversal potential (Erev) of I~ (-93 mV) was similar to EK (--94 mV for (K+)o ---- 4 mM), whereas Er~ of Ivs was -77 mV. The time constants for activation and deactivation of Iv~ made up a bell-shaped function of membrane potential, peaking between -30 and -40 mV (170 ms). The slope conductance of the linear portion of the fully activated Ig,-V relation was 22.5 S/F. Inward rectification of this relation occurred at potentials > -50 mV, resulting in a voltage-dependent decrease in peak Iv~ at test potentials > 0 InV. Peak Iw at 0 mV averaged 0.8 pA/pF (n ----- 21). Although the magnitude ofl~ was small relative to fully activated lw, the two currents were of similar magnitude when measured during a relatively short pulse protocol (225 ms) at membrane potentials (-20 to + 20 mV) typical of the plateau phase of cardiac action potentials.
Fluorescence anisotropy of a fatty acid covalently linked in vivo to the glycoprotein of vesicular stomatitis virus. (1981)

The covalently-attached fatty acid of the membrane glycoprotein (G) of vesicular stomatitis virus was fluorescently labeled biologically by isolating vesicular stomatitis virus from infected baby hamster kidney clone 21 cells that had been grown in the presence of 16(9-anthroyloxy)palmitate. The fluorescent labeling was specific for the G protein; the other viral membrane protein, the matrix (M) protein, was not labeled. Steady state fluorescence anisotropy of the 16(9-anthroyloxy)palmitate-labeled G protein reconstituted into dipalmitoylphosphatidylcholine vesicles indicated that the fatty acid attached to G protein is located in a dipalmitoylphosphatidylcholine domain that does not undergo the gel to liquid-crystalline phase transition.
Mineralogical classification and crystal water characterisation of beryl from the W–Sn–Be occurrence of Xuebaoding, Sichuan province, western China (2021)

Abstract Beryl from Xuebaoding, Sichuan Province, western China is known for its unusual tabular habit and W–Sn–Be paragenesis in a greisen-type deposit. The crystals are typically colourless transparent to pale blue, often with screw dislocations of hexagonal symmetry on the (0001) crystal faces. Combining electron microprobe analyses and laser ablation inductively coupled plasma mass spectrometry with single-crystal X-ray diffraction (XRD), correlated with Raman and micro-infrared (IR) spectroscopy and imaging, the crystal chemical characteristics are determined. The contents of Na + (0.24–0.38 atoms per formula unit (apfu)) and Li + up to 0.38 apfu are at the high end compared to beryl from other localities worldwide. Li + substitution for Be 2+ on the tetrahedral (T2) site is predominantly charge balanced by Na + on the smaller channel (C2) site, with Na + ranging from 91.5% to 99.7% (apfu) of the sum of all other alkali elements. Cs + and minor Rb + and K + primarily charge balance the minor M 2+ substitution for Al 3+ at the A site; all iron at the A site is suggested to be trivalent. The a axis ranges from 9.2161(2) to 9.2171(4) Å, with unit-cell volume from 678.03(3) to 678.48(7) Å 3 . The c/a ratio of 1.0002–1.0005 is characteristic for T2-type beryl with unit-cell parameters controlled primarily by Be 2+ substitution. Transmission micro-IR vibrational spectroscopy and imaging identifies coordination of one or two water molecules to Na + (type IIs and type IId, respectively) as well as alkali free water (type I). Based on IR absorption cross section and XRD a C1 site water content of 0.4–0.5 apfu is derived, i.e. close to 50% site occupancy. Secondary crystal phases with a decrease in Fe and Mg, yet increase in Na, suggest early crystallisation of aquamarine, with goshenite being late. With similar crystal chemistry to beryl of columnar habit from other localities worldwide, the tabular habit of Xuebaoding beryl seems to be unrelated to chemical composition and alkali content.
AdvancingModel-Based Design by Modeling Approximations of Computational Semantics (2011)

Over the past decades, engineered systems have increasingly come to rely on embedded computation in order to include advanced and sophisticated features. The unparallelled flexibility of software has been a blessing for implementing functionality with a complexity that could not have been imagined heretofore. One important manifestation of this is in the use of software as the universal system integration mechanism. With the increasing use, however, has come a suite of difficulties in effectively employing software engineering practices because (i) C (the language of choice in embedded software implementation) is very close to the hardware implementation and (ii) software engineering methods typically only consider logical correctness, irrespective of critical characteristics for embedded computation (e.g., response time). To address these problems, Model-Based Design helps raise the level of abstraction while accounting for such critical characteristics. The corresponding models are designed using high-level formalisms such as block diagrams and state transition diagrams whose meaning is particularly intuitive because of their executable nature. The necessity to support increasingly complicated language elements, however, has caused the underlying execution engine to explode in complexity. As a result, the meaning of the high-level formalisms exists almost exclusively by merit of simulation. This paper attempts to present the challenges faced by the current state of Model-Based Design tools and outlines a solution approach by modeling the execution engine.
Computationally Enabled Sensors (2021)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTComputationally Enabled SensorsMichael J. SailorMichael J. SailorMore by Michael J. Sailorhttps://orcid.org/0000-0002-4809-9826Cite this: ACS Sens. 2021, 6, 6, 1988–1989Publication Date (Web):June 25, 2021Publication History Received7 June 2021Published online25 June 2021Published inissue 25 June 2021https://pubs.acs.org/doi/10.1021/acssensors.1c01189https://doi.org/10.1021/acssensors.1c01189editorialACS PublicationsCopyright © 2021 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views955Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (706 KB) Get e-AlertscloseSUBJECTS:Density functional theory,Drug discovery,Elements,Pharmaceuticals,Sensors Get e-Alerts
151: Modulation of Calcium Currents in Bladder Sensory Neurons by Antimuscarinic Agents (2005)

You have accessJournal of UrologyDiscussed Poster, Sunday, May 22, 2005 8:00 am - 12:00 pm1 Apr 2005151: Modulation of Calcium Currents in Bladder Sensory Neurons by Antimuscarinic Agents Edward C. Burgard, Angela L. Bookout, David G. McKenna, Amy L. Kloster, Karl B. Thor, Matthew O. Fraser, and Daniel J. Ricca Edward C. BurgardEdward C. Burgard More articles by this author , Angela L. BookoutAngela L. Bookout More articles by this author , David G. McKennaDavid G. McKenna More articles by this author , Amy L. KlosterAmy L. Kloster More articles by this author , Karl B. ThorKarl B. Thor More articles by this author , Matthew O. FraserMatthew O. Fraser More articles by this author , and Daniel J. RiccaDaniel J. Ricca More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)34416-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "151: Modulation of Calcium Currents in Bladder Sensory Neurons by Antimuscarinic Agents." The Journal of Urology, 173(4S), p. 41 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 41 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Edward C. Burgard More articles by this author Angela L. Bookout More articles by this author David G. McKenna More articles by this author Amy L. Kloster More articles by this author Karl B. Thor More articles by this author Matthew O. Fraser More articles by this author Daniel J. Ricca More articles by this author Expand All Advertisement PDF DownloadLoading ...
ChemInform Abstract: INDIRECT DETECTION OF MERCURY‐199 NMR: ADDUCTS OF ETHYLMERCURY PHOSPHATE WITH AMINO ACIDS AND RIBONUCLEASE (1983)

Abstract Die 199Hg‐NMR‐Spektroskopie wird benutzt, um die Wechselwirkung von toxischem Ethyl‐Hg‐phosphat mit verschiedenen Aminosäuren zu untersuchen.
Genomic comparison of two Streptococcus suis serotype 1 strains recovered from porcine and human disease cases (2023)

Streptococcus suis is a zoonotic pathogen that causes invasive infections in humans and pigs. Although S. suis serotype 2 strains are most prevalent worldwide, other serotypes are also occasionally detected. Herein, we investigated the genomes of two S. suis serotype 1 strains belonging to the clonal complex 1, which were recovered from a human patient and an asymptomatic pig, respectively. The genomes differed in pathotype, virulence-associated gene (VAG) profile, minimum core genome (MCG) typing, and antimicrobial resistance gene content. The porcine serotype 1 strain was sequence type (ST) 237 and MCG1, whereas the human serotype 1 strain was ST105 and MCG ungroupable. Both strains were susceptible to several antibiotics consisting of β-lactams, fluoroquinolones, and chloramphenicol. Resistance to tetracycline, macrolides, and clindamycin was observed, which was attributed to the genes tet(O) and erm(B). Analysis of 99 VAG revealed Hhly3, NisK, NisR, salK/salR, srtG, virB4, and virD4 were absent in both serotype 1. However, the porcine strain lacked sadP (Streptococcal adhesin P), whereas the human strain harbored sadP1. Phylogenetic analysis revealed that human S. suis ST105 strains from Vietnam were genetically the closest to the human serotype 1 strain, whereas porcine S. suis ST11 strains from China and Thailand were genetically the closest to the porcine strain.
Effect of Read Disturb on Incomplete Blocks in MLC NAND Flash Arrays (2016)

The effect of read disturb on partially programmed blocks of MLC NAND is evaluated using experimental data from 2y-, 1y- and 1x-nm Flash memory devices. We demonstrate that when a partially programmed block is exposed to a large number of reads before it is finalized in terms of page programming, the remaining pages will exhibit a significant bit error-rate (BER) increase. The page-BER is characterized in terms of program-erase cycles and read cycles and is further analyzed based on the programmed threshold voltage distributions. The impact of the page programming algorithm is also discussed.
Pharmacokinetics and Pharmacodynamics of Macimorelin Acetate (AEZS-130) in Paediatric Patients With Suspected Growth Hormone Deficiency (GHD) (2021)

Abstract Growth hormone deficiency (GHD) in children is a rare, aetiologically diverse condition that results in growth failure and short stature. Inadequate response to two different growth hormone stimulation tests (GHST) is required for the diagnosis of GHD. Macimorelin acetate, a potent, orally administered growth hormone (GH) secretagogue, is approved by the FDA and EMA for the diagnosis of adult GHD. Study AEZS-130-P01 is the first of two studies to investigate macimorelin acetate as a diagnostic test in children with suspected GHD. This was an open-label, group comparison, dose escalation trial to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of single-dose 0.25, 0.5 and 1 mg/kg oral macimorelin acetate in paediatric subjects with suspected GHD. The macimorelin GHST was administered between two standard GHST, conducted as per local clinical practice, with a recovery period of 7-28 days between tests. Blood samples were collected pre-dose (±15 min) and 15, 30, 45, 60, 90, 120 and 360 minutes after macimorelin acetate intake. Overall, 24 paediatric subjects (8 per cohort [C1, C2, C3]) were included in the pharmacokinetic/pharmacodynamic (PK/PD) analysis. Five males and 3 females were observed in C1 and C2, 7 males and 1 female in C3. In all three cohorts, at least 3 subjects represented Tanner stages I or II. All 24 subjects (100%) were white, with a median age of 9.8, 9.0 and 10.5 years (range 4-15 years) and a median body-mass index of 16.1 kg/m2 (12.4-21.4 kg/m2) at screening. Overall, 88 adverse events were reported, many related to the standard GHST; none were considered related to the macimorelin test. Maximum plasma concentrations for macimorelin were mainly observed between 30-45 min. The mean Cmax values were 3.46, 8.13 and 12.87 ng/ml for C1, C2, and C3, respectively. The AUCs increased with dose; the mean AUC0-6 values were 6.69, 18.02 and 30.92 h*ng/mL. The mean elimination half-lives were 1.22, 1.61 and 1.71 h, respectively. PK and PD profiles for all three cohorts were comparable, with peak GH levels mainly observed within 30-60 min following macimorelin intake. Macimorelin acetate was safe and well tolerated in all dosing cohorts. A dose-dependent increase in macimorelin Cmax and AUC in children and adolescents correlated well with data from adult subjects. A robust dose-proportional GH response was also achieved. PD results showed that GH response was comparable in all dose groups, with a slight shift to earlier tmax at higher macimorelin doses.
Autocrine/Paracrine Regulation of Breast Cancer Cell Proliferation by Growth Hormone Releasing Hormone via Ras, Raf, and Mitogen-Activated Protein Kinase (2006)

Although GHRH has previously been shown to regulate proliferation of breast cancer cells and prevent apoptosis, the intracellular pathways mediating this effect have not been clarified. Exogenous GHRH stimulated a dose-dependent proliferative response within 24 h in MDA-231, as well as in T47D cells and in MCF-7 cells transfected with the GHRH receptor. The proliferation of MDA-MB-231 (MDA-231) cells was associated with an increase in tritiated thymidine uptake. In addition, phosphorylation of MAPK was rapidly stimulated by GHRH. The phosphorylation of MAPK by GHRH was prevented by transfection of the cells with dominant-negative Ras or Raf or by pretreatment of cells with Raf kinase 1 inhibitor. The inhibition of Ras and Raf, as well as the inhibition of MAPK phosphorylation by PD98059, also prevented GHRH-induced cell proliferation. Finally, pretreatment of cells with the somatostatin analog, BIM23014, also prevented GHRH-induced MAPK phosphorylation and cell proliferation. These results indicate that GHRH stimulates dose-dependent cell proliferation of MDA-231 breast cancer cells through a pathway that requires Ras, Raf, and MAPK phosphorylation. The results also provide support for a possible autocrine/paracrine antagonism between GHRH and somatostatin in the regulation of MDA-231 cell population maintenance. Taken together, the studies provide further insight into the possible role of GHRH as a growth factor in breast cancer.
Broadband Frequency Comb for Calibration of Astronomical Spectrographs (2016)

We present our state-of-the-art version of a frequency comb for calibration of astronomical spectrographs. The mode spacing of the frequency comb can be designed to match the resolution of a spectrograph. Combined with its excellent accuracy and stability, the spectral coverage of more than 70% of the whole visible spectrum range makes the frequency comb an ideal calibration source. In addition, the new version introduces the automatic start-up function that brings convenience to the astronomers.
Coding of segmented images using shape-independent basis functions (1998)

An important issue in object-based image coding is the efficient description of image segments having an arbitrary shape. This paper outlines a solution to this task using basic principles of transform image coding that are generalized for the case of arbitrarily shaped image segments. The texture inside each region is successively approximated using two-dimensional (2-D) shape-independent basis functions defined on a rectangle circumscribing the given image segment. The resulting texture description exhibits a high energy compactness and is well suited for low bit rate image coding. Unlike other approaches aimed at segment-oriented image coding, the proposed concept does not couple texture description with contour coding. The computational load is kept low, especially for the decoding process.