gebhart/patrepeval huggingface dataset:
Neoadjuvant oncolytic virotherapy before surgery sensitizes triple-negative breast cancer to immune checkpoint therapy (2018)

Triple-negative breast cancer (TNBC) is an aggressive disease for which treatment options are limited and associated with severe toxicities. Immunotherapeutic approaches like immune checkpoint inhibitors (ICIs) are a potential strategy, but clinical trials have demonstrated limited success in this patient cohort. Clinical studies using ICIs have revealed that patients with preexisting anticancer immunity are the most responsive. Given that oncolytic viruses (OVs) induce antitumor immunity, we investigated their use as an ICI-sensitizing approach. Using a therapeutic model that mimics the course of treatment for women with newly diagnosed TNBC, we demonstrate that early OV treatment coupled with surgical resection provides long-term benefits. OV therapy sensitizes otherwise refractory TNBC to immune checkpoint blockade, preventing relapse in most of the treated animals. We suggest that OV therapy in combination with immune checkpoint blockade warrants testing as a neoadjuvant treatment option in the window of opportunity between TNBC diagnosis and surgical resection.
A versatile genomic transgenesis platform with enhanced λ integrase for human Expi293F cells (2023)

Reliable cell-based platforms to test and/or produce biologics in a sustainable manner are important for the biotech industry. Utilizing enhanced λ integrase, a sequence-specific DNA recombinase, we developed a novel transgenesis platform involving a fully characterized single genomic locus as an artificial landing pad for transgene insertion in human Expi293F cells. Importantly, transgene instability and variation in expression were not observed in the absence of selection pressure, thus enabling reliable long-term biotherapeutics testing or production. The artificial landing pad for λ integrase can be targeted with multi-transgene constructs and offers future modularity involving additional genome manipulation tools to generate sequential or nearly seamless insertions. We demonstrated broad utility with expression constructs for anti PD-1 monoclonal antibodies and showed that the orientation of heavy and light chain transcription units profoundly affected antibody expression levels. In addition, we demonstrated encapsulation of our PD-1 platform cells into bio-compatible mini-bioreactors and the continued secretion of antibodies, thus providing a basis for future cell-based applications for more effective and affordable therapies.
Using counter example guided abstraction refinement to find complex bugs (2004)

In this paper, we present a method for finding failure traces for safety properties that are out of reach for traditional approaches to counter example generation. We do this by guiding bounded model checking (BMC) with information gathered from counter example guided abstraction refinement. Unlike previously described approaches based on reconstructing abstract counter examples on the concrete machines, we do not limit ourselves to search for failures of the same length as the current abstract counterexample. We also describe a combination of previously known methods for choosing registers to include in the abstraction that we have found works very well together with our technique for finding failures. Our experimental results show that the resulting method can find counter examples that are out of range for both standard BMC and two previously published approaches to abstraction-guided BMC.
Reactions of low‐energy ions with ferrocene self‐assembled monolayer surfaces (1993)

Abstract Collisions of low‐energy Cr(CO) ( n = 0, 2, 6) ions with self‐assembled monolayer surfaces bearing covalently bound ferrocene groups result in transfer of the cyclopentadienyl ligand into the gas phase as the Cr(C 5 H 5 ) + ion. High fluences of Cr + ions lead to deposition of Cr at the surface and subsequent Xe + collisions liberate the metal ion. The Cr atoms deposited on the surface appear to be chemically bonded to the cyclopentadienyl rings. The implications of these results for modification of surfaces using ion beams are discussed.
Recent Technical Advances in Accelerating the Clinical Translation of Small Animal Brain Imaging: Hybrid Imaging, Deep Learning, and Transcriptomics (2022)

Small animal models play a fundamental role in brain research by deepening the understanding of the physiological functions and mechanisms underlying brain disorders and are thus essential in the development of therapeutic and diagnostic imaging tracers targeting the central nervous system. Advances in structural, functional, and molecular imaging using MRI, PET, fluorescence imaging, and optoacoustic imaging have enabled the interrogation of the rodent brain across a large temporal and spatial resolution scale in a non-invasively manner. However, there are still several major gaps in translating from preclinical brain imaging to the clinical setting. The hindering factors include the following: (1) intrinsic differences between biological species regarding brain size, cell type, protein expression level, and metabolism level and (2) imaging technical barriers regarding the interpretation of image contrast and limited spatiotemporal resolution. To mitigate these factors, single-cell transcriptomics and measures to identify the cellular source of PET tracers have been developed. Meanwhile, hybrid imaging techniques that provide highly complementary anatomical and molecular information are emerging. Furthermore, deep learning-based image analysis has been developed to enhance the quantification and optimization of the imaging protocol. In this mini-review, we summarize the recent developments in small animal neuroimaging toward improved translational power, with a focus on technical improvement including hybrid imaging, data processing, transcriptomics, awake animal imaging, and on-chip pharmacokinetics. We also discuss outstanding challenges in standardization and considerations toward increasing translational power and propose future outlooks.
The application of massively parallel sequencing technologies in diagnostics (2010)

Massively parallel sequencing (MPS) is rapidly evolving and is starting to be utilized by the clinical field as well as diagnostics. We describe major recent advances that have come about as a result of the application of MPS in the biomedical field and the first approaches in medical genetics that have made use of MPS. Without any doubt, MPS has proven to be a very powerful technique. To unravel the capabilities of MPS for patient care, the most important aspect for the acceptance of MPS within clinics and diagnostics is to guarantee that the large amount of data undergoes vitally important analyses and interpretation and is securely managed.
A Categorical Course Curriculum for Radiology Residencies (1988)

A categorical course curriculum was introduced at Brooke Army Medical Center to focus the content of daily conferences and lectures according to radiology subspecialties. Our goal was to improve the traditional uncoordinated conferences and apprenticeship approach to resident learning. After one-year's experience, resident performance has improved, and residents and staff greatly prefer this style of teaching. The format has been adopted.
The Optimal Placement of Ferrite in Inductive Power Transfer Coupling Pads (2021)

Inductive power transfer (IPT) system performance is critically affected by the placement of ferrite material in IPT pads. However, current placement design approaches rely on specialist knowledge and trial-and-error effort. Furthermore, these approaches depend on a given initial pad structure. Hence, design flexibility is constrained, and the performance limits of what is possible are unexplored. Therefore, this paper proposes a ferrite structure design approach based on topology optimization that maximizes the coupling performance of circular IPT pads, subject to a ferrite volume constraint. The proposed approach allows pad designs to be quickly generated, easily simplified for manufacturability, and does not depend on a given initial structure. Simulation results are presented, proving optimality in terms of mutual inductance and tolerance to IPT pad misalignment compared to an existing pad design with bar-shaped ferrite pieces. Independence of the need for an initial structure allows for novel pad structure identification and the realization of new performance levels.
Phase II clinical trial with long-term infusion of anti-GD2 antibody ch14.18/CHO in combination with interleukin-2 (IL2) in patients with high risk neuroblastoma. (2016)

10562 Background: A new delivery method of anti-GD2 antibody ch14.18/CHO by long term infusion (LTI) may improve the toxicity profile but maintain effective immune modulation and clinical activity in patients (pts) with high risk relapsed/refractory neuroblastoma (NB). Methods: 124 pts were enrolled into an open label SIOPEN Phase II clinical trial (EudraCT 2009-018077-31) to receive up to 5 cycles of 6x106 IU/m2 sc IL2 (d1-5; 8-12), LTI of 100 mg/m2 ch14.18/CHO (d8-17) and 160 mg/m2 oral 13-cis-RA (d19-32)(APN311-202). Primary efficacy endpoints were antibody ( > 1µg/ml) and NK-cell levels. Toxicity endpoint was i.v. morphine free antibody delivery after 5 days of cycle 1 in > 80% patients. Secondary endpoints were increased ADCC levels over baseline, Fc gamma receptor (FCGR) polymorphisms, objective clinical responses and progression free as well as overall survival. Results: All per protocol treated patients met primary efficacy endpoints. This translated into an increase in ADCC in all evaluable patients. Toxicity observed in this trial was improved compared to standard delivery methods of anti-GD2 antibodies. Objective clinical response rate observed in this trial was 40%. The survival update of the cohort revealed a 2-y OS of 64±6% (mean OS 2.7± 0.2 y, median PFS 3.7 y (95% CI: 2.0-3.7 y)) and a 2-y PFS of 53 ± 6% (mean PFS 2.0 ± 0.2 y, median PFS 2.3 y (95% CI: 1.2-3.3 y)). This result is clearly superior to historical controls not treated with ch14.18/CHO (p < 0.001), indicating clinical efficacy of the treatment. In this cohort, we found 63/124 pts with low affinity FCGR alleles (FCGR2A-H131R/R and/or FCGRA3A-V158 F/F). These patients showed lower EFS and OS rates compared to 59/124 patients with high affinity FCGR polymorphisms (p < 0.05). These findings underline FCGR mediated ADCC as mechanism of action of this treatment modality. Conclusions: Results of this Phase II study show efficacy, clinical activity and improved toxicity profile of a new delivery method of ch14.18/CHO and underline ADCC as the mechanism of action. Clinical trial information: NCT01701479.
Data from Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma (2023)

&lt;div&gt;Abstract&lt;p&gt;Statins, commonly used to treat hypercholesterolemia, have been shown to trigger tumor-specific apoptosis in certain cancers, including multiple myeloma (MM), a plasma cell malignancy with poor prognosis. In this article, we show that of a panel of 17 genetically distinct MM cell lines, half were sensitive to statin-induced apoptosis and, despite pharmacodynamic evidence of drug uptake and activity, the remainder were insensitive. Sensitive cells were rescued from lovastatin-induced apoptosis by mevalonate, geranylgeranyl PPi, and partially by farnesyl PPi, highlighting the importance of isoprenylation. Expression profiling revealed that Rho GTPase mRNAs were differentially expressed upon lovastatin exposure in sensitive cells, yet ectopic expression of constitutively active Rho or Ras proteins was insufficient to alter sensitivity to lovastatin-induced apoptosis. This suggests that sensitivity involves more than one isoprenylated protein and that statins trigger apoptosis by blocking many signaling cascades, directly or indirectly deregulated by the oncogenic lesions of the tumor cell. Indeed, clustering on the basis of genetic abnormalities was shown to be significantly associated with sensitivity (&lt;i&gt;P&lt;/i&gt; = 0.003). These results suggest that statins may be a useful molecular targeted therapy in the treatment of a subset of MM. [Mol Cancer Ther 2007;6(6):1886–97]&lt;/p&gt;&lt;/div&gt;
UHD Video Stitching Method for Enhanced User Experience (2015)

네트워크 전송 기술의 발달에 따라 IPTV 시장이 급격히 성장하고 있다. 또한 더 좋은 서비스를 사용자에게 제공하는 UHD급 방송 및 UX가 주목 받고 있다. 반면에 기존 UX와 차별화 된 사용자 경험을 극대화 할 수 있는 기술에 대한 연구는 많이 진행되지 않고 있다. 따라서 본 논문에서는 사용자가 한 화면에서 여러 채널 및 비디오 콘텐츠를 동시에 시청할 수 있는 멀티뷰 서비스와 이를 수행하는 저복잡도 구문 수준 영상합성 기술을 제안한다. 실험 결과, 제안 알고리즘은 Full-HD 해상도를 가진 4개 영상, UHD급 영상을 1초에 80장 이상 합성할 수 있어, 실시간 적용이 가능함을 보여준다. Along with the development of network transmission technology, the IPTV market is growing in fast pace. Additionally the UHD resolution broadcasting system along with user experience (UX) that provides better service to user has attracted attention recently since there are not enough research has been done with differentiated the UX that can enhance the UX yet. Therefore we proposed a low complexity syntax level image stitching implementation technique that run with multi-view services, which makes possibility to view multiple channel or video contents on the screen at the same time. Simulation results have demonstrated the liability and effectiveness of the proposed algorithm by showing that capability of generating more than 80 frames per second by stitching four Full-HD size videos into UHD frame.
A Key 6G Challenge and Opportunity - Connecting the Remaining 4 Billions: A Survey on Rural Connectivity (2019)

Providing connectivity to around half of the World population living in rural or underprivileged areas is a tremendous challenge, but also a unique opportunity. In this paper, a survey of technologies for providing connectivity to rural areas, and that can help address this challenge, is provided. Fronthaul and backhaul techniques are discussed. In addition, energy and cost efficiency of the studied technologies are analyzed. Typical application scenarios in rural areas are discussed, and several country-specific use cases are surveyed. Directions for future evolution of rural connectivity are outlined.
High Mobility IZTO Thin‐Film Transistors Based on Spinel Phase Formation at Low Temperature through a Catalytic Chemical Reaction (2023)

In this paper, In<sub>0.22</sub> Zn<sub>δ</sub> Sn<sub>0.78-</sub> <sub>δ</sub> O<sub>1.89-</sub> <sub>δ</sub> (δ = 0.55) films with a single spinel phase are successfully grown at the low temperature of 300 °C through careful cation composition design and a catalytic chemical reaction. Thin-film transistors (TFTs) with amorphous In<sub>0</sub> <sub>.22</sub> Zn<sub>δ</sub> Sn<sub>0.78-</sub> <sub>δ</sub> O<sub>1.89-</sub> <sub>δ</sub> (δ = 0.55) channel layers have a reasonable mobility of 41.0 cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup> due to the synergic intercalation of In and Sn ions. In contrast, TFTs with polycrystalline spinel In<sub>0</sub> <sub>.22</sub> Zn<sub>δ</sub> Sn<sub>0.78-</sub> <sub>δ</sub> O<sub>1.89-</sub> <sub>δ</sub> (δ = 0.55) channel layers, achieved through a metal-induced crystallization at 300 °C, exhibit a remarkably high field-effect mobility of ≈83.2 cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup> and excellent stability against external gate bias stress, which is attributed to the uniform formation of the highly ordered spinel phase. The relationships between cation composition, microstructure, and performance for the In<sub>2</sub> O<sub>3</sub> -ZnO-SnO<sub>2</sub> ternary component system are investigated rigorously to attain in-depth understanding of the roles of various crystalline phases, including spinel Zn<sub>2-</sub> <sub>y</sub> Sn<sub>1-</sub> <sub>y</sub> In<sub>2</sub> <sub>y</sub> O<sub>4</sub> (y = 0.45), bixbyite In<sub>2-2</sub> <sub>x</sub> Zn<sub>x</sub> In<sub>x</sub> O<sub>4</sub> (x = 0.4), rutile SnO<sub>2</sub> , and a homologous compound of compound (ZnO)<sub>k</sub> (In<sub>2</sub> O<sub>3</sub> ) (k = 5). This work concludes that the cubic spinel phase of Zn<sub>2-</sub> <sub>y</sub> Sn<sub>1-</sub> <sub>y</sub> In<sub>2</sub> <sub>y</sub> O<sub>4</sub> (y = 0.45) film is a strong contender as a substitute for semiconducting polysilicon as a backplane channel ingredient for mobile active-matrix organic light-emitting diode displays.
A spontaneous pulmonary fibrosis mouse model identifies a mechanism for ILC2-mediated irreversible fibrosis (2022)

Abstract Pulmonary fibrosis (PF) is characterised by inflammation and collagen deposition in the alveolar interstitium, leading to dyspnoea and death. However, the comprehensive pathogenesis of PF remains unclear due to the lack of spontaneous fibrosis mouse models. Here, we found that Ifngr1 -/- Rag2 -/- mice, lacking the mechanisms to suppress group 2 and 3 innate lymphoid cells (ILC2s and ILC3s), developed severe PF spontaneously. In Ifngr1 -/- Rag2 -/- mice, Il1rl1 hi Il13 hi -ILC2 subpopulation was increased at disease-onset phase before collagen production began. Further, defects in ILCs or IL-33, the strong ILC2 activator, prevented PF development. ILC2s directly induce collagen production by fibroblasts in vitro , and fibroblasts started to produce IL-33 in the chronic phase, presumably forming a positive feedback loop between fibroblasts and ILC2s leading to irreversible fibrosis. Moreover, the increased IL1RL1 and IL13 and decreased IFNGR1 expression levels in ILC2s from human idiopathic PF patients highlight the significance of the novel mouse model in fibrosis research.
Simulation of the effects of chain architecture on the sorption of ethylene in polyethylene (2004)

An osmotic ensemble hyperparallel tempering technique has been developed to study the solubility of ethylene in amorphous linear low-density polyethylene of different chain architectures. The NERD united-atom force field (Nath, Escobedo, and de Pablo revised united-atom force field) is used in all simulations. We have investigated the effect of polyethylene chain length and branching on ethylene solubility. In this study, we have considered short-chain branching of amorphous linear low-density ethylene-1-hexene copolymers under typical polymerization reactor conditions. It is observed that, in the polymer, ethylene prefers to reside in the vicinity of polymer chain ends. This clustering causes a decrease in ethylene solubility with polymer chain length. When short-chain branches are introduced to a linear polymer chain, however, the chain-end clustering effect is counteracted by a higher density, thereby leading to an ethylene solubility almost identical to that in the linear polymer.
Infrarenal Aortic Stenosis: Value of Stent Placement after Percutaneous Transluminal Angioplasty Failure (2001)

When aortic diameter is taken into consideration, there is no evidence that clinical outcome after secondary aortic stent placement would be poorer than technically successful PTAA.
Multi-photon entanglement: from quantum curiosity to quantum computing and quantum repeaters (2007)

In the emerging field of quantum information technology the two basic subfields are quantum communication and quantum computation. Photonic qubits are considered as most promising information carriers for this new technology due to the immense advantage of suffering negligible decoherence. Additionally, the very small photon-photon interactions can be replaced by inducing effective nonlinearities via measurements which allow for the implementation of crucial two-qubit gate operations. Although the spontaneous parametric down-conversion gives access to the generation of highly entangled few-photon states, such as four-qubit cluster states which allow to demonstrate the new concept of the one-way quantum computer, its applicability is highly limited due to the poor scaling of the simultaneous emission of more than one-entangled photon pair. Therefore of particular interest is the reversible mapping of qubits from photon states to atomic states. This might allow the implementation of photonic quantum repeaters for long-distance quantum communication or the generation of arbitrary multi-photon states as required for linear-optics quantum computing. Thus for the realization of such a quantum network several approaches for achieving the required quantum control between matter and photons have been studied during the past few years. Recent experiments demonstrating the generation of narrow-bandwidth single photons using a room-temperature ensemble of <sup>87</sup>Rb atoms and electromagnetically induced transparency should emphasize the progress towards such a quantum network.
Efficient syntheses of dioxorhenium(V) complexes (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEfficient syntheses of dioxorhenium(V) complexesJohn C. Brewer and Harry B. GrayCite this: Inorg. Chem. 1989, 28, 17, 3334–3336Publication Date (Print):August 1, 1989Publication History Published online1 May 2002Published inissue 1 August 1989https://pubs.acs.org/doi/10.1021/ic00316a017https://doi.org/10.1021/ic00316a017research-articleACS PublicationsRequest reuse permissionsArticle Views261Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Normal-mode analysis for signal fluctuations in the Yellow Sea (1997)

This paper presents a normal mode approach for analyzing signal fluctuation in shallow water with a thermocline which fluctuates due to tides and internal waves. In the Yellow Sea 1996 experiment, variations of thermocline structure and internal waves were observed by CTD and thermistor chains. The cw and FM acoustic signals were measured over a 12-h period with two 16-hydrophone vertical arrays deployed 3.11 and 10.32 km from the source. The cw pulses were used to observe fluctuation at four specified frequencies. Amplitude fluctuations of more than 20 dB were observed. The FM signals were used to isolate individual normal modes by pulse compression and mode filtering. The influence of internal waves on the normal-mode structure and signal fluctuation was examined. It was found that the variation of the thermocline was significant in determining acoustic signal fluctuation. The normal-mode structure and dispersion relations in the channel depend strongly on the thermocline. Variation of the thermocline thus causes phase and group velocity to become variable. This leads to signal fluctuation, since the amplitude of the received signal is determined by interference between arriving modes. The study also showed that the amplitude fluctuation is weaker at shorter range.
Neuroprotection by the α2-Adrenoreceptor Agonist Dexmedetomidine in a Focal Model of Cerebral Ischemia (1993)

Results from this study indicate that postischemic administration of dexmedetomidine, in a dose that reduces the anesthetic requirements by 50%, has a neuroprotective effect in this model of focal cerebral ischemia.