gebhart/patrepeval huggingface dataset:
Further analysis of LSM-based unit pruning forunit selection TTS (2008)

The level of quality that can be achieved in concatenative text-to-speech synthesis is primarily governed by the inventory of units used in unit selection. This has led to the collection of ever larger corpora in the quest for ever more natural synthetic speech. As operational considerations limit the size of the unit inventory, however, pruning is critical to removing any instances that prove either spurious or superfluous. At last ICASSP we introduced an alternative pruning strategy based on a data-driven feature extraction framework separately optimized for each unit type in the inventory. This paper presents further validation of this strategy, as well as a detailed analysis of its potential benefits for concatenative synthesis.
Viscosified Flow Control of Enhanced Geothermal Systems (2011)

Enhanced Geothermal Systems can produce water temperatures that may serve as heat source for conventional steam cycles employed for electrical power generation. Laboratory experiments on the rheological behaviour of the working fluid under rock flow condi
A Novel Polyacrylamide Magnetic Nanoparticle Contrast Agent for Molecular Imaging using MRI (2003)

A novel polyacrylamide superparamagnetic iron oxide nanoparticle platform is described which has been synthetically prepared such that multiple crystals of iron oxide are encapsulated within a single polyacrylamide matrix (PolyAcrylamide Magnetic [PAM] nanoparticles). This formulation provides for an extremely large T2 and T2* relaxivity of between 620 and 1140 sec(-1) mM(-1). Administration of PAM nanoparticles into rats bearing orthotopic 9L gliomas allowed quantitative pharmacokinetic analysis of the uptake of nanoparticles in the vasculature, brain, and glioma. Addition of polyethylene glycol of varying sizes (0.6, 2, and 10 kDa) to the surface of the PAM nanoparticles resulted in an increase in plasma half-life and affected tumor uptake and retention of the nanoparticles as quantified by changes in tissue contrast using MRI. The flexible formulation of these nanoparticles suggests that future modifications could be accomplished allowing for their use as a targeted molecular imaging contrast agent and/or therapeutic platform for multiple indications.
Alternative paradigm for physical computing (2002)

We identify a different class of physical systems that are able to form universal logic gates. By analogy with Si(100) surface dimers, we present a model to analyze the trajectories of the fixed points (interpreted as logic states) under variation of the basic parameters. Using the perspective of catastrophe theory, we show that information processing is the result of cycling the parameters of such systems through a path containing a cusp-type catastrophe. We apply this analysis to the construction of an example based on magnetic memory.
The alignment of dichroic dyes in a nematic liquid crystal: a molecular dynamics investigation (2018)

The absorption properties of a dye molecule depend on its orientation relative to the light source. Thus the ability to predict how well a particular dye aligns with a liquid crystal host will improve the design of smart materials. One measurement of this alignment is the order parameter, which can be calculated from molecular dynamics simulations. The results for three dyes are presented here. The orientation of the long molecular axis of the dye relative to the liquid crystal director can range from perpendicular to parallel, with the dyes studied having an average order parameter of the dye similar to the average order parameter of the host.
Single Enantiomer of YK-4-279 Demonstrates Specificity in Targeting the Oncogene EWS-FLI1 (2012)

Oncogenic fusion proteins, such as EWS-FLI1, are excellent therapeutic targets as they are only located within the tumor. However, there are currently no agents targeted toward transcription factors, which are often considered to be 'undruggable.' A considerable body of evidence is accruing that refutes this claim based upon the intrinsic disorder of transcription factors. Our previous studies show that RNA Helicase A (RHA) enhances the oncogenesis of EWS-FLI1, a putative intrinsically disordered protein. Interruption of this protein-protein complex by small molecule inhibitors validates this interaction as a unique therapeutic target. Single enantiomer activity from a chiral compound has been recognized as strong evidence for specificity in a small molecule-protein interaction. Our compound, YK-4-279, has a chiral center and can be separated into two enantiomers by chiral HPLC. We show that there is a significant difference in activity between the two enantiomers. (S)-YK-4-279 is able to disrupt binding between EWS-FLI1 and RHA in an immunoprecipitation assay and blocks the transcriptional activity of EWS-FLI1, while (R)-YK-4-279 cannot. Enantiospecific effects are also established in cytotoxicity assays and caspase assays, where up to a log-fold difference is seen between (S)-YK-4-279 and the racemic YK-4-279. Our findings indicate that only one enantiomer of our small molecule is able to specifically target a protein-protein interaction. This work is significant for its identification of a single enantiomer effect upon a protein interaction suggesting that small molecule targeting of intrinsically disordered proteins can be specific. Furthermore, proving YK-4-279 has only one functional enantiomer will be helpful in moving this compound towards clinical trials.
The role of the psoas and iliacus muscles for stability and movement of the lumbar spine, pelvis and hip (1995)

The activation patterns of the psoas and iliacus muscles were investigated in 7 healthy adult subjects (4 men and 3 women) during a variety of motor tasks in standing, sitting and lying. Myoelectric activity was recorded simultaneously from the 2 muscles using thin wire electrodes inserted under guidance of high-resolution ultrasound. In general, both muscles were coactivated, albeit to different relative levels, particularly when hip flexor torque was required. Selective activation of the iliacus could, however, be seen to stabilize the pelvis in contralateral hip extension during standing. Psoas was found to be selectively involved in sitting with a straight back and in contralateral loading situations requiring stabilization of the spine in the frontal plane. During training exercises from a supine position, such as sit-ups, the contribution of the psoas and iliacus muscles could be varied by changing the range of motion as well as the position and support for the legs. Thus, the 2 anatomically different muscles of the iliopsoas complex were shown to have individual and task-specific activation patterns depending on the particular demands for stability and movement at the lumbar spine, pelvis and hip.
A transient method for mass‐transfer characterization through supported zeolite membranes: Extension to two components (2012)

In a previous work (Courthial et al.) a transient state characterization method for zeolite supported membranes has been proposed and tested for single components in the Henry domain. An extension of the method to single components beyond the Henry domain and to binary mixtures is described. Since the method is based on experiments performed within the linear domain, the dynamic model previously developed for single components in the Henry domain is extended. The parameter estimation procedure that is described is based on a deep analysis of the model structure with respect to its structural identifiability properties. Some experimental results concerning pure n ‐butane as well as isobutane/ n ‐butane mixtures transport through mordenite framework inverted (MFI)‐supported membranes are finally shown to illustrate the technique. © 2012 American Institute of Chemical Engineers AIChE J, 59: 959–970, 2013
Performances of sampled amplitude sequence detectors on a partial erasure magnetic recording channel (2002)

The performance of sampled amplitude sequence detectors are evaluated for a model of the magnetic recording channel. In particular, the performance of detectors currently used with run-length-limited codes having d=0 and d=1 constraints are compared including code rate loss, practical equalization and partial erasure effects. It is shown that a d=0 PR4 detector performs slightly better than a d=1 EEPR4 detector at reasonable user densities when the channel is linear. However, in the partial erasure channel model used, the d=1 detector has a significant advantage.
An efficient and accurate frailty model approach for genome-wide survival association analysis controlling for population structure and relatedness in large-scale biobanks (2020)

Abstract With decades of electronic health records linked to genetic data, large biobanks provide unprecedented opportunities for systematically understanding the genetics of the natural history of complex diseases. Genome-wide survival association analysis can identify genetic variants associated with ages of onset, disease progression and lifespan. We developed an efficient and accurate frailty (random effects) model approach for genome-wide survival association analysis of censored time-to-event (TTE) phenotypes in large biobanks by accounting for both population structure and relatedness. Our method utilizes state-of-the-art optimization strategies to reduce the computational cost. The saddlepoint approximation is used to allow for analysis of heavily censored phenotypes (&gt;90%) and low frequency variants (down to minor allele count 20). We demonstrated the performance of our method through extensive simulation studies and analysis of five TTE phenotypes, including lifespan, with heavy censoring rates (90.9% to 99.8%) on ~400,000 UK Biobank participants with white British ancestry and ~180,000 samples in FinnGen, respectively. We further performed genome-wide association analysis for 871 TTE phenotypes in UK Biobank and presented the genome-wide scale phenome-wide association (PheWAS) results with the PheWeb browser.
Decoding schemes for foliated sparse quantum error-correcting codes (2018)

Foliated quantum codes are a resource for fault-tolerant measurement-based quantum error correction for quantum repeaters and for quantum computation. They represent a general approach to integrating a range of possible quantum error correcting codes into larger fault-tolerant networks. Here, we present an efficient heuristic decoding scheme for foliated quantum codes, based on message passing between primal and dual code ``sheets.'' We test this decoder on two different families of sparse quantum error correcting code: turbo codes and bicycle codes, and show reasonably high numerical performance thresholds. We also present a construction schedule for building such code states.
6G vision: An ultra-flexible perspective (2020)

The upcoming sixth generation (6G) communications systems are expected to support an unprecedented variety of applications, pervading every aspect of human life. It is clearly not possible to fulfill the service requirements without actualizing a plethora of flexible options pertaining to the key enabler technologies themselves. At that point, this work presents an overview of the potential 6G key enablers from the flexibility perspective, categorizes them, and provides a general framework to incorporate them in the future networks. Furthermore, the role of artificial intelligence and integrated sensing and communications as key enablers of the presented framework is also discussed.
Disrupted Resting State Network of Fibromyalgia in Theta frequency (2018)

Fibromyalgia (FM), chronic widespread pain, exhibits spontaneous pain without external stimuli and is associated with altered brain activities during resting state. To understand the topological features of brain network in FM, we employed persistent homology which is a multiple scale network modeling framework not requiring thresholding. Spontaneous magnetoencephalography (MEG) activity was recorded in 19 healthy controls (HCs) and 18 FM patients. Barcode, single linkage dendrogram and single linkage matrix were generated based on the proposed modeling framework. In theta band, the slope of decrease in the number of connected components in barcodes showed steeper in HC, suggesting FM patients had decreased global connectivity. FM patients had reduced connectivity within default mode network, between middle/inferior temporal gyrus and visual cortex. The longer pain duration was correlated with reduced connectivity between inferior temporal gyrus and visual cortex. Our findings demonstrated that the aberrant resting state network could be associated with dysfunction of sensory processing in chronic pain. The spontaneous nature of FM pain may accrue to disruption of resting state network.
Second-order moment analysis of dispersion-managed solitons (1999)

This paper shows how a second-order moment analysis can be used to derive explicit approximate expressions for the evolution of the root-mean-square (rms) width and chirp parameters of a dispersion-managed soliton within one period of the dispersion map. The energy enhancement factor can also be estimated with a good accuracy.
Cyanobacterial phycobilisomes. Role of the linker polypeptides in the assembly of phycocyanin. (1982)

The phycocyanin-containing segments of the rod substructures of Anabaena variabilis phycobilisomes consist of complexes of phycocyanin with "linker" polypeptides of 27,000 and 32,500 daltons (Yu, M.-H., Glazer, A. N., and Williams, R. C. (1981) J. Biol. Chem. 256, 13130-13136). Complexes (alpha beta)3.27,000, (alpha beta)3.32,500, (alpha beta)6.27,000, [(alpha beta)6.32,500]n, (alpha beta)6.27,000 - (alpha beta)6.32,500 were prepared, where alpha beta represents a monomer of phycocyanin, and 27,000 and 32,500 represent the 27,000- and 32,500-dalton polypeptides, respectively. Tryptic digestion of (alpha beta)3.32,500 leads to a stable (alpha beta)3.28,000 complex which does not form higher aggregates. The 32,500 polypeptide is stable to trypsin in the [(alpha beta)6.32,500]n and (alpha beta)6.27,000 - [(alpha beta)6.32,500]n=1.2 aggregates. Upon trypsin treatment of all 27,000 still assembled into higher aggregates, (alpha beta)6.21,0900 and (alpha beta)6.21,000 - (alpha beta)6.32,500. The spectroscopic properties of phycocyanin-linker polypeptide complexes were not modified by the tryptic cleavages. These results show that the 32,500 polypeptide has two distinct functional domains, a 28,000 portion necessary to the stabilization of a trimeric phycocyanin complex and a 4,500 domain which links consecutive phycocyanin hexamers in the rod substructure. The 27,000 polypeptide likewise has two distinct functional domains: a 21,000 domain stabilizes a trimeric phycocyanin complex, a 6,000 domain is exposed in all of the assembly forms examined. From these and earlier studies, it is concluded that the 6,000 domain functions in the attachment of the rod substructures to the core of the phycobilisome.
Head Ejection during Barrier Impacts (2011)

During oblique vehicular impacts with longitudinal barriers, an occupant’s head is often ejected out of a side window. When this occurs, the occupant’s head can contact the barrier or an object attached thereto. This impact event, often termed head slap, normally produces a serious injury or fatality. Roadside barriers and any attached hardware should be designed with sufficient offset at the top to preclude head slap for most impact conditions. The goal of this study was to identify the extent of head ejection that can be expected during high-speed crashes with longitudinal barriers. High-speed videos of full-scale vehicle crash tests were analyzed to determine the occupant head trajectories. Videos of 11 full-scale crash tests with both small cars and pickup trucks were analyzed to produce a head ejection envelope to encompass all head trajectories observed in the tests. Adjustments were made to the envelope to account for varying vehicle heights, seated passenger heights, and vehicle movements during impact. Two head ejection envelopes were created; one to encompass ejections from occupants at or below the 50th percentile male seated height and the other to encompass ejections from occupants at or below the 95th percentile male seated height. The final head ejection envelopes were constructed as a template for designing future barrier systems and for determining the safe placement of fixed objects on top of or behind rigid parapets.
Faculty Opinions recommendation of SNARE proteins: one to fuse and three to keep the nascent fusion pore open. (2012)

Neurotransmitters are released through nascent fusion pores, which ordinarily dilate after bilayer fusion, preventing consistent biochemical studies. We used lipid bilayer nanodiscs as fusion partners; their rigid protein framework prevents dilation and reveals properties of the fusion pore induced by SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor). We found that although only one SNARE per nanodisc is required for maximum rates of bilayer fusion, efficient release of content on the physiologically relevant time scale of synaptic transmission apparently requires three or more SNARE complexes (SNAREpins) and the native transmembrane domain of vesicle-associated membrane protein 2 (VAMP2). We suggest that several SNAREpins simultaneously zippering their SNARE transmembrane helices within the freshly fused bilayers provide a radial force that prevents the nascent pore from resealing during synchronous neurotransmitter release. PMID: 22422984 Funding information This work was supported by: NIDDK NIH HHS, United States Grant ID: R37 DK027044 NIDDK NIH HHS, United States Grant ID: R01 DK027044
ClnH6-nSiGe Compounds for CMOS Compatible Semiconductor Applications:  Synthesis and Fundamental Studies (2007)

We describe the synthesis of a new family of chlorinated Si-Ge hydrides based on the formula ClnH6-nSiGe. Selectively controlled chlorination of H3SiGeH3 is provided by reactions with BCl3 to produce ClH2SiGeH3 (1) and Cl2HSiGeH3 (2). This represents a viable single-step route to the target compounds in commercial yields for semiconductor applications. The built-in Cl functionalities are specifically designed to facilitate selective growth compatible with CMOS processing. Higher order polychlorinated derivatives such as Cl2SiHGeH2Cl (3), Cl2SiHGeHCl2 (4), ClSiH2GeH2Cl (5), and ClSiH2GeHCl2 (6) have also been produced for the first time leading to a new class of highly reactive Si-Ge compounds that are of fundamental and practical interest. Compounds 1-6 are characterized by physical and spectroscopic methods including NMR, FTIR, and mass spectroscopy. The results combined with first principles density functional theory are used to elucidate the structural, thermochemical, and vibrational trends throughout the general sequence of ClnH6-nSiGe and provide insight into the dependence of the reaction kinetics on Cl content in the products. The formation of 1 was also demonstrated by an alternative route based on the reaction of (SO3CF3)SiH2GeH3 and CsCl. Depositions of 1 and 2 at very low temperatures (380-450 degrees C) produce near stoichiometric SiGe films on Si exhibiting monocrystalline microstructures, smooth and continuous surface morphologies, reduced defect densities, and unusual strain properties.
On decoding rank-metric codes over large fields (2017)

A decoding algorithm is presented for rank-metric array codes that are based on diagonal interleaving of MDS codes. W.r.t. this metric, such array codes are known to be optimal when the underlying field is algebraically closed. It is also shown that for any list decoding radius that is smaller than the minimum rank distance, the list size can be bounded from above by an expression that is independent of the field.
Electron-enhanced SiO2 atomic layer deposition at 35 °C using disilane and ozone or water as reactants (2023)

Electrons can enhance SiO2 atomic layer deposition (ALD) at low temperatures using disilane (Si2H6) and either ozone (O3/O2) or water (H2O) as reactants. SiO2 electron-enhanced ALD (EE-ALD) was demonstrated at 35 °C by exposing the sample to sequential electron, oxygen reactant, and Si2H6 exposures. The reaction sequence was electron beam exposure for 3 s, purge for 5 s, O3/O2 or H2O exposure at 0.5–1.0 Torr for 3 s, purge for 10 s, Si2H6 exposure at 100 mTorr for 1 s, and purge for 15 s. The electron exposure was an electron current of ∼150 mA for 3 s. The electrons were produced by a hollow cathode plasma electron source typically operating with a grid bias of ≈−300 V. These electrons could irradiate a sample area of ∼2 × 2 cm2. In situ spectroscopic ellipsometry measurements determined that SiO2 EE-ALD films nucleated rapidly and deposited linearly versus number of EE-ALD cycles. The SiO2 EE-ALD growth rate was 0.89 Å/cycle using O3/O2 and 0.88 Å/cycle using H2O. The SiO2 growth rate was also self-limiting at higher electron and Si2H6 exposures. In addition, SiO2 EE-ALD films were grown by changing the reaction sequence or codosing the electrons with the oxygen reactant. The SiO2 EE-ALD films could be grown on conducting silicon wafers or insulating SiO2 films. SiO2 EE-ALD is believed to be possible on insulating SiO2 films because the secondary electron yield for SiO2 at electron energies of ∼100–300 eV is greater than unity. Under these conditions, the SiO2 film charges positive during electron exposure and then pulls back secondary electrons to maintain charge neutrality. The SiO2 EE-ALD films had properties that were comparable with thermal SiO2 oxides. The refractive indices of the SiO2 EE-ALD films were similar at n = 1.44 ± 0.02 for various process conditions and equivalent to the refractive index of a wet thermal SiO2 oxide film. In addition, all the SiO2 EE-ALD films yielded etch rates in dilute buffered oxide etch solution that were only slightly higher than the etch rate of a thermal SiO2 oxide film. SiO2 EE-ALD should be useful to deposit high-quality SiO2 films for various applications at low temperatures.
Fabrication of silicon based microfluidics device for cell sorting application (2014)

In this paper we report on a novel silicon fabrication process of a microfluidics device used for cell sorting application. The process uses wafer level fabrication technique that allows for a small form factor device in combination with a new photopatternable polymer with excellent properties for microfluidics on silicon. The ability to process on wafer level distinguish this from other processes, whose yields are limited to few test samples. The device fabrication includes: processing of micro-heaters, definition of polymer microfluidic channels and collective die-to-wafer bonding of glass substrate onto the polymer channels. The paper will focus on the development of a wafer scale process flow and initial characterization of the available devices.