gebhart/patrepeval huggingface dataset:
BPS-001, a complex biologic agent extracted from the medicinal leech (Huridinaria manillensis) for treatment of metastatic castration-resistant prostate cancer. (2016)

209 Background: We established that subcutaneous BPS-001 reduced tumor size and inhibited tumor growth in PC3, LNCaP and 22RV-1 mouse xenografts; and, tumor lHC demonstrated an increase in caspase-3 and decreases in expression of P21, Ki-67 and PCNA. We also showed that BPS-001 reduced PSA expression in both In vitro and in In vivo xenografts (LNCaP and 22RV1). We now demonstrate that BPS-001 inhibits angiogenesis in the xenografts; and, In vitro studies demonstrate that BPS-001 affects expression of adhesion molecules and the androgen receptor. In addition, BPS-001 inhibited tumor growth in a TRAMP allograft model. Methods: CD31 expression was measured using IHC of the previous mouse xenografts. In vitro androgen receptor and adhesion molecule expression were assessed by Western blot. Transplantable TRAMP-C2 mouse prostate cancer in B57CL allografts were grown to 5 mm prior to initiation of treatment. Immune markers in TRAMP allograft tumors were measured by IHC. Results: Mechanistic studies show BPS-001 acts by blocking angiogenesis demonstrated by a &gt; 50% decrease in expression of CD31 in the LNCaP and 22RV-1 xenografts. Furthermore, preliminary toxicology studies show similar efficacy to docetaxel with no weight loss in the longer-term PC3 xenograft study as was observed with docetaxel. Preliminary toxicology studies of BPS-001 also support a favorable toxicity profile, and the therapeutic dose (1-5 mg/Kg, QW or BIW) is well within the margin of safety. Dose limiting toxicity (bleeding) was observed at doses of 20mg/Kg daily. In vitro studies showed BPS-001 decreased expression of both N- and P- cadherins and the androgen receptor. BPS-001 inhibited tumor growth in the TRAMP allograft models. IHC analyses of the TRAMP allograft tumors suggest immunomodulation. Conclusions: BPS-001 exhibits anticancer activity with no observed toxicity in the therapeutic range. Effects of BPS-001 include inhibition of angiogenesis, downregulation of adhesion molecules associated with advanced prostate cancer and inhibition of androgen receptor signaling. Elucidation of the mechanism of action is ongoing.
Suppl video 2 from Neutrophil Conversion to a Tumor-Killing Phenotype Underpins Effective Microbial Therapy (2023)

&lt;p&gt;Neutrophil interactions with LLC cells in unmanipulated and treated tumors.&lt;/p&gt;
Relationship between Internal Energy and Volume Change of Mixing in Pressurized Polymer Blends (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTRelationship between Internal Energy and Volume Change of Mixing in Pressurized Polymer BlendsA. A. Lefebvre, J. H. Lee, N. P. Balsara, B. Hammouda, R. Krishnamoorti, and S. KumarView Author Information Department of Chemical Engineering, Chemistry, and Materials Science, Polytechnic University, Six Metrotech Center, Brooklyn, New York 11201; National Institute of Standards and Technology, Building 235, E 151, Gaithersburg, Maryland 20899; Department of Chemical Engineering, University of Houston, 4800 Calhoun, Houston, Texas 77204; and Department of Materials Science and Engineering, Pennsylvania State University, University Park, Pennsylvania 16802 Cite this: Macromolecules 1999, 32, 16, 5460–5462Publication Date (Web):July 23, 1999Publication History Received17 March 1999Published online23 July 1999Published inissue 1 August 1999https://pubs.acs.org/doi/10.1021/ma990392yhttps://doi.org/10.1021/ma990392yrapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views301Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Internal energy,Mixtures,Monomers,Polymer blends,Scattering Get e-Alerts
ChemInform Abstract: MEMBRANE TRANSPORT SYSTEMS. I. SYNTHESIS AND CHARACTERIZATION OF CARRIERS FOR R A PROTON DRIVEN ALKALI METAL CATION PUMP (1981)

Abstract Die durch Anwendung von Tl‐ethanolat modifizierte Williamsonsche Ethersynthese liefert aus 2R,3R‐Weinsäure‐bis‐dimethylamid und dem entsprechenden Oligoethylenglykoldiiodid das Diamid (Ia); dies ergibt nach saurer Hydrolyse zu (Ib) und vorsichtiger Dehydratisierung mit überschüssigem Acetylchlorid das Anhydrid (II).
MicroRNA Expression in Cancer (2017)

Overview In the last two decades, researchers have identified a novel group of noncoding RNAs (ncRNAs) classified according to their function and size. The best studied of these ncRNAs termed microRNAs (miRNAs) are short noncoding RNAs that are approximately 22 nucleotides in length and play a key role in the regulation of a large number of biological processes and diseases, including cancer. Since the initial description of an association between miRNA and cancer in 2002, miRNAs have emerged as central regulators of processes fundamental to the initiation and progression of cancer. More recently, miRNAs have been detected in bodily fluids including blood, sputum, and urine, thus making them potential noninvasive diagnostic and prognostic biomarkers of disease. The application of miRNAs in human cancer therapy has become a fascinating field of study, representing one of the newest frontiers for cancer treatment. However, our knowledge for these small molecules and their application to human cancers is still growing. In this chapter, we provide an overview of the connection between miRNAs and cancer with a focus on translation to human application.
Effect of ketoprofen on Escherichia coli heat-stable enterotoxin-induced diarrhea of calves. (1993)

To evaluate the effect of ketoprofen on fecal output during secretory diarrhea, 16 calves were given approximately 200 micrograms of heat-stable Escherichia coli enterotoxin by suckling on 2 occasions. On one day, treatment was not administered. On the other day, either 3 mg of ketoprofen/kg of body weight (n = 8) or 6 mg of ketoprofen/kg (n = 8) was administered 1 hour before and 3 hours after administration of enterotoxin. Fecal output was no different after 8 or 24 hours from calves given 3 mg/kg, but fecal output was less at 8 hours and 24 hours for calves given 6 mg/kg (P = 0.0588), compared with the control day.
Distributed sensing of electromagnetic components using optical fiber based methods (2023)

An OFDR based fiber-optics sensor for distributed real-time temperature rise monitoring of a transformer in operation has been disclosed. The fiber-optic sensor provides an effective solution to monitoring the physical structures of the transformer core, as well as accurately detecting the non-uniform temperature distribution inside the transformer, and thus provides innovative feedback to the transformer design by minimizing the core losses. Additionally, the method may be responsive to the presence of magnetic and electric fields, as well as responsive to various chemical species. The method allows novel approaches to real-time asset monitoring of power transformers while operational.
Supplementary Methods from Clusterin Inhibition Using OGX-011 Synergistically Enhances Hsp90 Inhibitor Activity by Suppressing the Heat Shock Response in Castrate-Resistant Prostate Cancer (2023)

&lt;p&gt;PDF file 76K&lt;/p&gt;
Copper Kills Escherichia coli Persister Cells (2020)

Due to their reduced metabolism, persister cells can survive most antimicrobial treatments, which usually rely on corrupting active biochemical pathways. Therefore, molecules that kill bacterial persisters should function in a metabolism-independent manner. Some anti-persister compounds have been found previously, such as the DNA-crosslinkers mitomycin C and cisplatin, but more effective and lower cost alternatives are needed. Copper alloys have been used since ancient times due to their antimicrobial properties, and they are still used in agriculture to control plant bacterial diseases. By stopping transcription with rifampicin and by treating with ampicillin to remove non-persister cells, we created a population that consists solely of <i>Escherichia coli</i> persister cells. Using this population of persister cells, we demonstrate that cupric compounds kill <i>E. coli</i> persister cells. Hence, copper ions may be used in controlling the spread of important bacterial strains that withstand treatment with conventional antimicrobials by forming persister cells.
Effective Monitoring of Freeloading User in the Presence of Active User in Cognitive Radio Networks (2013)

In cognitive networks, primary and secondary users (PUs and SUs) share the radio resource according to fair regulations. The goal of this paper is to introduce a new method to detect an unfair user (freeloader) that hides its radio signal under the noise floor in the presence of an active (either primary or secondary) user. The performance of the proposed technique is evaluated by theoretical analysis and computer simulations. The probability of detection is expressed, for constant false-alarm rates, as a function of both the active signal power and the background noise variance. The results show the effectiveness of the new monitoring algorithm in several operating cases.
A new hybrid electrospray Fourier transform mass spectrometer: design and performance characteristics (2005)

A new hybrid electrospray quadrupole Fourier transform mass spectrometry (FTMS) instrument design is shown and characterized. This instrument involves coupling an electrospray source and mass-resolving quadrupole, ion accumulation, and collision cell linear ion trap system developed by MDS Sciex with a home-built ion guide and ion cyclotron resonance (ICR) cell. The iterative progression of this design is shown. The final design involves a set of hexapole ion guides to transfer the ions from the accumulation/collision trap through the magnetic field gradient and into the cell. These hexapole ion guides are separated by a thin gate valve and two conduction limits to maintain the required <10(-9) mbar vacuum for FTICR. Low-attomole detection limits for a pure peptide are shown, 220 000 resolving power in broadband mode and 820 000 resolving power in narrow-band mode are demonstrated, and mass accuracy in the <2 ppm range is routinely available provided the signal is abundant, cleanly resolved, and internally calibrated. This instrument design provides high experimental flexibility, allowing Q2 CAD, SORI-CAD, IRMPD, and ECD experiments with selected ion accumulation as well as experiments such as nozzle skimmer dissociation. Initial top-down mass spectrometry experiments on a protein is shown using ECD.
Oblivious Routing with Mobile Fusion Centers over a Sensor Network (2007)

We consider the problem of aggregating data at a mobile fusion center (fusor) (eg. a PDA or a cellular phone) moving within a spatial region over which a wireless sensor network (eg., fixed motes) has been deployed. Each sensor node generates packets destined to the fusor, and our objective is to develop strategies that can route the packets to the mobile fusor. For an arbitrary (possibly random) fusor mobility pattern over any connected subset of the sensor deployment area, we first derive upper bounds on the aggregation data rate (i.e., the uniform rate region from each sensor node to the mobile fusor), where we allow all sensor nodes to have complete knowledge of the mobility pattern of the fusor. We then consider aggregation data rates that can be achieved when the mobility pattern of the fusor is unknown to the sensor nodes. Surprisingly, we show that for a class of mobility patterns (random mobility over connected-compositions of convex sets of the deployment region, e.g. random walks over piece-wise linear sets), we can construct "universal" mobility-oblivious routing strategies that achieve aggregation data rates that are of the same order as the (mobility-aware) upper bound.
Labyrinthine concussion following gunshot injury: A case report (2016)

Labyrinthine concussion may lead to reduced vestibular reflex pathway following gunshot wounds to the temporal bone. Clinical presentation is likely to vary significantly among cases.
Acrylic Resin Molding Based Head Fixation Technique in Rodents (2016)

Head fixation is a technique of immobilizing animal's head by attaching a head-post on the skull for rigid clamping. Traditional head fixation requires surgical attachment of metallic frames on the skull. The attached frames are then clamped to a stationary platform resulting in immobilization of the head. However, metallic frames for head fixation have been technically difficult to design and implement in general laboratory environment. In this study, we provide a novel head fixation method. Using a custom-made head fixation bar, head mounter is constructed during implantation surgery. After the application of acrylic resin for affixing implants such as electrodes and cannula on the skull, additional resins applied on top of that to build a mold matching to the port of the fixation bar. The molded head mounter serves as a guide rails, investigators conveniently fixate the animal's head by inserting the head mounter into the port of the fixation bar. This method could be easily applicable if implantation surgery using dental acrylics is necessary and might be useful for laboratories that cannot easily fabricate CNC machined metal head-posts.
Carbon nanotube supercellulose supercapacitor (2014)

Supercellulose gel and single-wall carbon nanotubes (SWCNTs) were used for the creation of binder-free electrode for supercapacitor application and the properties of the electrode were investigated in aqueous electrolyte. Two layers of the formed composite material were inserted on graphite current collectors and separated from each other by a separator to create a supercapacitor prototype for measurements. Different concentrations of SWCNTs were studied and 65% concentration of SWCNTs resulted in the highest specific capacitance.
Growth hormone induces insulin resistance in Laron dwarf cells via lactogenic receptors. (1993)

GH is the hormone primarily responsible for regulating body size within the genetic program. While GH has pleiotropic actions on cellular growth and metabolism, most of its effects are believed to be mediated by a single GH receptor. This receptor is not functional in tissues from patients with Laron dwarfism. We used human T-cell leukemia virus-immortalized T-lymphoblast cell lines from Laron dwarfs and normal individuals to examine the mechanism of GH-induced insulin resistance at the cellular level. GH (5-500 micrograms/L) caused a profound decrease in the sensitivity of normal T-lymphoblasts in response to all insulin concentrations (P < 0.0001 vs. insulin alone); pretreatment with GH and GH receptor antibody significantly improved sensitivity to all concentrations of insulin (P = NS vs. insulin alone). Preincubation with GH and PRL receptor antibody was associated with partial improvement in insulin sensitivity (P = 0.004 vs. insulin alone). Thus, in normal T-cell lines, the major pathway of GH-induced insulin resistance appears to be directed by the GH receptor, with a smaller effect mediated through the PRL receptor. While T-cell lines from Laron dwarfs do not respond to GH in clonal proliferation assays, GH (50 and 100 micrograms/L) caused profound insulin resistance in these cells (P = 0.008 and P < 0.0001, respectively, vs. insulin alone). GH receptor antibody did not abrogate this effect at any insulin concentration (P = NS vs. insulin alone), but there was partial restoration of insulin sensitivity when GH and PRL receptor antibody were coincubated (P = 0.0069 vs. insulin alone). Thus, in Laron T-cell lines, PRL and perhaps other lactogenic receptors appear to mediate GH-induced insulin resistance. The kinetics of GH-induced insulin resistance in Laron T-cells were also distinct from the pattern seen in normal T-cells, and unlike in normal cells, GH had no effect on insulin-like growth factor-I-induced clonal expansion of Laron T-cell lines (P = NS vs. insulin-like growth factor-I alone). These results provide evidence for an alternative pathway of GH action revealed in cells lacking classical growth responses to GH.
ChemInform Abstract: PI‐GEBUNDENE KOMPLEXE DES TETRAPHENYLBORAT‐IONS MIT RHODIUM(I) UND IRIDIUM(I) (1970)

Abstract Die Komplexe (I), in denen das Tetraphenylborat‐Ion über eine 1r(h° )‐Bindung an das Metallion koordiniert ist, entstehen durch Behandlung wäßrig‐methanolischer Lösungen der Metall(III)‐chloridtrihydrate mit linearen und cyclischen Diolefinen in Gegenwart von Na‐tetraphenylborat in meist 70‐80%iger Ausbeute.
Longitudinal Trends of Financial Toxicity in Patients With Lung Cancer: A Prospective Cohort Study (2021)

FT is a pervasive challenge during the initiation of lung cancer treatment. Few patients are willing to sacrifice medical care regardless of the cost. Risk factors for FT evolve, resulting in unique interventional targets throughout therapy.
Variable Delay Transmission Lines in advanced CMOS SOI technology (2014)

Variable (Delay) Transmission Lines (VTL) offer digital tuning of fabricated transmission lines to compensate for process variation in active and passive devices of RF silicon design enabling self-healing and post-production circuit tuning. A novel compact semi-analytic single ended VTL model, enabling accurate RFIC circuit level simulation to enhance design flow, was developed. VTL structures were fabricated and measured in IBM 32nm CMOS SOI technology. The 30,50,80 Ohm VTL structures, consisting of metal crossing lines between the signal line and ground plane that are connected to ground through CMOS switches, exhibit over 11%, 15%, 18% delay tuning range respectively with low insertion loss and good agreement between measured results and developed model simulations.
Supplementary Table S1 from Genetic Variants Implicate Dual Oxidase-2 in Familial and Sporadic Nonmedullary Thyroid Cancer (2023)

&lt;p&gt;Supplemental Table 1. PCR and sequencing primers&lt;/p&gt;
Low Temperature Semiconductor Device Processing (2022)

In the manufacturing of integrated circuits, etching and deposition processes with and without plasma are widely used. Except for physical processes such as Physical Vapor Deposition and Ion Beam Etching, these processes leverage the adsorption of reactive neutrals to enable chemical reactions at the wafer surface. In this paper, we will investigate the fundamentals and applicability of low temperatures to stimulate physisorption of neutrals. Among the points of interest for this approach are the use of less reactive gases, higher fluxes to the surface, new transport mechanisms into high aspect ratio features, and 3D effects thanks to condensation in small features. We will discuss temperature and pressure ranges for relevant material and pre-cursor gas combinations and means to initiate the deposition and etching reactions. An overview of experimental results from our research and the literature will be presented.
The Creatine Kinase System Is Essential for Optimal Refill of the Sarcoplasmic Reticulum Ca2+ Store in Skeletal Muscle (2002)

Muscle function depends on an adequate ATP supply to sustain the energy consumption associated with Ca(2+) cycling and actomyosin sliding during contraction. In this regulation of energy homeostasis, the creatine kinase (CK) circuit for high energy phosphoryl transfer between ATP and phosphocreatine plays an important role. We earlier established a functional connection between the activity of the CK system and Ca(2+) homeostasis during depolarization and contractile activity of muscle. Here, we show how CK activity is coupled to the kinetics of spontaneous and electrically induced Ca(2+) transients in the sarcoplasm of myotubes. Using the UV ratiometric Ca(2+) probe Indo-1 and video-rate confocal microscopy in CK-proficient and -deficient cultured cells, we found that spontaneous and electrically induced transients were dependent on ryanodine-sensitive Ca(2+) release channels, sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase pumps, extracellular calcium, and functional mitochondria in both cell types. However, at increasing sarcoplasmic Ca(2+) load (induced by electrical stimulation at 0.1, 1, and 10 Hz), the Ca(2+) removal rate and the amount of Ca(2+) released per transient were gradually reduced in CK-deficient (but not wild-type) myotubes. We conclude that the CK/phosphocreatine circuit is essential for efficient delivery of ATP to the sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase pumps and thereby directly influences sarcoplasmic reticulum refilling and the kinetics of the sarcoplasmic Ca(2+) signals.
Planar space robots with coupled joints: differentially flat designs (2004)

The motion of free-floating space robots is characterized by nonholonomic, i.e., non-integrable rate constraint equations. These constraints originate from principles of conservation of linear and angular momentum. Trajectory planning of these systems is extremely challenging and computation intensive since the motion must satisfy differential constraints. However, under certain conditions, these drift-less control systems can be shown to be differentially flat. The property of flatness allows a computationally inexpensive way to plan trajectories for the dynamic system between two configurations as well as develop feedback controllers. In this paper, nonholonomic rate constraints for free-floating planar open-chain robots are studied together with auxiliary joint variable constraints to determine design conditions under which the system exhibits differential flatness. Sufficient conditions are derived for existence of flatness and are illustrated by examples.