gebhart/patrepeval huggingface dataset:
THE PERFORMANCE OF WEAK-CONSISTENCY REPLICATION PROTOCOLS (1992)

Weak-consistency replication protocols can be used to build wide-area services that are scalable, fault-tolerant, and useful for mobile computer systems. We have developed the timestamped anti-entropy protocol, which provides reliable eventual delivery with a variety of message orderings. Pairs of replicas periodically exchange update messages; in this way updates eventually propagate to all replicas. In this paper we present a detailed analysis of the fault tolerance and the consistency provided by this protocol. The protocol is extremely robust in the face of site and network failure, and it scales well to large numbers of replicas. 1
Checkpoint Inhibition in Non-Hodgkin's Lymphoma (2017)

As patients continue to die from malignant lymphoma, novel treatment options continue to be warranted. To successfully grow and spread, tumor cells need to escape the immune system; therefore, the augmentation or restoration of immune effectors against the malignant cell could be of great value, as shown, e.g., for allogeneic transplantation. A deepened understanding of the regulation of activation and inhibition of the T cell-based effector mechanisms has led to the development of drugs that are able to modify specific checkpoints of this system and thereby raise an immune response against tumor cells. With dramatic responses observed in Hodgkin's disease (HD), interest has risen to explore these drugs in non-Hodgkin's lymphoma (NHL). Available data underline the potential of checkpoint inhibitors in a variety of lymphoma entities, such as primary mediastinal B cell lymphoma (PMBCL) or central nervous system (CNS) lymphoma, and there is hope that a significant proportion of patients will finally benefit. However, intensive efforts are needed to develop optimal screening tools, combinations, and sequences to explore the full potential of these new classes of therapeutic agents.
Comparison of the Transcriptomic Signatures in Pediatric and Adult CML (2021)

Children with chronic myeloid leukemia (CML) tend to present with higher white blood counts and larger spleens than adults with CML, suggesting that the biology of pediatric and adult CML may differ. To investigate whether pediatric and adult CML have unique molecular characteristics, we studied the transcriptomic signature of pediatric and adult CML CD34+ cells and healthy pediatric and adult CD34+ control cells. Using high-throughput RNA sequencing, we found 567 genes (207 up- and 360 downregulated) differentially expressed in pediatric CML CD34+ cells compared to pediatric healthy CD34+ cells. Directly comparing pediatric and adult CML CD34+ cells, 398 genes (258 up- and 140 downregulated), including many in the Rho pathway, were differentially expressed in pediatric CML CD34+ cells. Using RT-qPCR to verify differentially expressed genes, VAV2 and ARHGAP27 were significantly upregulated in adult CML CD34+ cells compared to pediatric CML CD34+ cells. NCF1, CYBB, and S100A8 were upregulated in adult CML CD34+ cells but not in pediatric CML CD34+ cells, compared to healthy controls. In contrast, DLC1 was significantly upregulated in pediatric CML CD34+ cells but not in adult CML CD34+ cells, compared to healthy controls. These results demonstrate unique molecular characteristics of pediatric CML, such as dysregulation of the Rho pathway, which may contribute to clinical differences between pediatric and adult patients.
A Model for Predicting Nephrotoxicity in Patients Treated with Aminoglycosides (1986)

We have previously identified risk factors for nephrotoxicity in 204 patients receiving aminoglycosides. We added data on an additional 134 patients from the University of Chicago who were treated for longer periods (13.1 +/- 9.4 days) to determine if duration of therapy was also a risk factor. In the combined populations, nephrotoxicity developed in 59 (17.5%) of 338 patients, and duration of therapy was the factor most strongly associated with nephrotoxicity (P less than .0001). A new predictive model was developed that was then tested prospectively on 175 consecutive medical and surgical patients who had plasma levels of aminoglycoside measured. The new model accurately identified 14 of 15 patients with nephrotoxicity (sensitivity = 93%) and 106 of 160 without nephrotoxicity (specificity = 66%). A bedside scoring system accurately identified high-risk and low-risk patients. We believe these data add to the understanding of the clinical correlates of aminoglycoside nephrotoxicity and aid in the identification of high-risk patients.
ChemInform Abstract: Synthesis and Human β‐Adrenoceptor Activity of 1‐(3,5‐Diiodo‐4‐methoxybenzyl)‐1,2,3,4‐tetrahydroisoquinolin‐6‐ol Derivatives in vitro. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Al18F labeling of peptides and proteins (2014)

Radiolabeled receptor-binding peptides and proteins have emerged as an important class of radiopharmaceuticals that have changed radionuclide imaging in clinical practice. Many strategies have been developed to radiolabel these peptide and proteins with fluorine-18. The majority of these methods is time-consuming and suffer from low yields. A more straightforward approach was proposed a few years ago, based on the chelation of aluminum fluoride by (1,4,7-triazacyclononane-1,4,7-triacetic acid). This approach has been optimized with regard to labeling yield and specific activity. In addition, crystallography studies have led to the design of optimized chelators. Subsequently, the Al(18) F technology is finding widespread use in labeling peptides and proteins. Various hapten peptides for pre-targeting studies have been labeled with Al(18) F, as well as αv β3 integrin-binding peptides have been studied, and also larger peptides, such as exendin-4 and affibody molecules and heat-labile proteins have been labeled with Al(18) F. Here, we summarize the development, optimization, and applications of the Al(18) F labeling technology.
Organic Reactions at Alumina Surfaces. Mild, Selective, and High-Yield Oxidation of Cyclobutanol to Cyclobutanone (1977)

Cyclobutanol (I) an wasserfreiem Aluminiumoxid wird durch Chloral (II) in Tetrachlorkohlenstoff bei 25°C quantitativ zu Cyclobutanon (III) oxidiert.
Techniques for the Dynamic Randomization of Network Attributes. (2016)

Abstract not provided.
Development of a Cryo-Pre-Embedding Immunogold Labeling Protocol for the Ultrastructural Localization of PDL1 in Human Tonsils (2023)

Journal Article Development of a Cryo-Pre-Embedding Immunogold Labeling Protocol for the Ultrastructural Localization of PDL1 in Human Tonsils Get access Miriam Baca, Miriam Baca Genentech, Research Pathology, Center for Advanced Light and Electron Microscopy, South San Francisco, CA, USA Search for other works by this author on: Oxford Academic Google Scholar Cecile Chalouni, Cecile Chalouni Genentech, Research Pathology, Center for Advanced Light and Electron Microscopy, South San Francisco, CA, USA Search for other works by this author on: Oxford Academic Google Scholar Hartmut Koeppen, Hartmut Koeppen Genentech, Research Pathology, Center for Advanced Light and Electron Microscopy, South San Francisco, CA, USA Search for other works by this author on: Oxford Academic Google Scholar Linda Rangell, Linda Rangell Genentech, Research Pathology, Center for Advanced Light and Electron Microscopy, South San Francisco, CA, USA Search for other works by this author on: Oxford Academic Google Scholar Meredith Sagolla, Meredith Sagolla Genentech, Research Pathology, Center for Advanced Light and Electron Microscopy, South San Francisco, CA, USA Search for other works by this author on: Oxford Academic Google Scholar Mike Reichelt Mike Reichelt Genentech, Research Pathology, Center for Advanced Light and Electron Microscopy, South San Francisco, CA, USA Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 29, Issue Supplement_1, 1 August 2023, Pages 1123–1124, https://doi.org/10.1093/micmic/ozad067.575 Published: 22 July 2023
Time-steered array with a chirped grating beamformer (1997)

The authors have developed a novel, simple chirped-grating based beamformer for time-steered array antennas. The beamformer is based on commercially available chirped fibre gratings and optical circulators and has a measured bandwidth of over 18 GHz. The first-ever array demonstration achieves quasi-continuous 1D steering over 45°.
Finite element and neural network models for process optimization in selective laser sintering (2004)

An iterative method to optimize non-linear production processes is described. In contrast to classical design-of-experiment methods, it starts with a small number of experiments, based on which a preliminary data-based model is developed. From this model a vector of process parameters with (potentially) improved performance is calculated. The results of the experiment carried out with these new process parameters enlarge the database and result in an improved process model. The iteration is stopped if the requirements of the product properties are fulfilled. The method is applied to the selective laser sintering process of titanium powder. The goal of the optimization is to produce a ring with a prescribed geometry. One innovation of this approach is to feed the database with experimental results obtained from process simulation. The purpose of the simulation is to use the sintering machine only once to produce a part that is ‘right first time’. The simulation is based on a three-dimensional finite element model of the selective laser sintering process. The input data are the various process parameters and the model is sufficiently detailed to predict the density and the bounding quality (sintering potential) of the manufactured part.
Heterogeneity and chimerism of endothelial cells revealed by single-cell transcriptome in orthotopic liver tumors (2020)

The liver is a common host organ for cancer, either through lesions that arise in liver epithelial cells [e.g., hepatocellular carcinoma (HCC)] or as a site of metastasis by tumors arising in other organs (e.g., colorectal cancer). However, the changes that occur in liver stromal cells in response to cancer have not been fully characterized, nor has it been determined whether the different sources of liver cancer induce distinct stromal changes. Here, we performed single-cell profiling of liver stromal cells from mouse models of induced spontaneous liver cancer or implanted colorectal liver metastases, with a focus on tumor endothelial cells (ECs). While ECs in liver tissue adjacent to cancerous lesions (so-called adjacent normal) corresponded to liver zonation phenotypes, their transcriptomes were also clearly altered by the presence of a tumor. In comparison, tumor EC transcriptomes show stronger similarities to venous than sinusoidal ECs. Further, tumor ECs, independent of tumor origin, formed distinct clusters displaying conserved "tip-like" or "stalk-like" characteristics, similar to ECs from subcutaneous tumors. However, they also carried liver-specific signatures found in normal liver ECs, suggesting an influence of the host organ on tumor ECs. Our results document gene expression signatures in ECs in liver cancer and show that the host organ, and not the site of tumor origin (liver versus colorectal), is a primary determinant of EC phenotype. In addition, primarily in tumors, we further defined a cluster of chimeric cells that expressed both myeloid and endothelial cell markers and might play a role in tumor angiogenesis.
Model-free Deep Reinforcement Learning for Urban Autonomous Driving (2019)

Urban autonomous driving decision making is challenging due to complex road geometry and multi-agent interactions. Current decision making methods are mostly manually designing the driving policy, which might result in sub-optimal solutions and is expensive to develop, generalize and maintain at scale. On the other hand, with reinforcement learning (RL), a policy can be learned and improved automatically without any manual designs. However, current RL methods generally do not work well on complex urban scenarios. In this paper, we propose a framework to enable model-free deep reinforcement learning in challenging urban autonomous driving scenarios. We design a specific input representation and use visual encoding to capture the low-dimensional latent states. Several state-of-the-art model-free deep RL algorithms are implemented into our framework, with several tricks to improve their performance. We evaluate our method in a challenging roundabout task with dense surrounding vehicles in a high-definition driving simulator. The result shows that our method can solve the task well and is significantly better than the baseline.
Deep learning‐based coronary artery motion estimation and compensation for short‐scan cardiac CT (2021)

The Deep PAMoCo provides an efficient approach to increase the diagnostic value of cardiac CT scans even if they are highly corrupted by motion.
Shot-to-shot diagnostic of the longitudinal photon source position at the SPring-8 Angstrom Compact Free Electron Laser by means of x-ray grating interferometry (2016)

We present single-shot measurements of the longitudinal photon source position of the SPring-8 Angstrom Compact Free Electron Laser x-ray free electron laser by means of x-ray grating interferometry. The measurements were performed in order to study the behavior of the source under normal operation conditions and as a dependence on the active undulator length. The retrieved experimental results show that x-ray grating interferometry is a powerful in situ monitoring tool for investigating and tuning an x-ray free electron laser.
DOP053 Impact of concomitant immunomodulator use on vedolizumab effectiveness: a multicentre consortium propensity score-matched analysis (2018)

We compared the effectiveness of vedolizumab (VDZ) for Crohn’s disease (CD) and ulcerative colitis (UC) when used alone vs. in combination with an immunomodulator (IM). Using a multicentre US-based consortium of Inflammatory Bowel disease (IBD) patients treated with VDZ, we performed propensity score matching for concomitant IM use (1:1) accounting for CD vs. UC, age, sex, prior disease-related hospitalisation within the previous year, disease severity, steroid refractoriness or dependence, prior tumour necrosis factor (TNF)-antagonist failure, number of prior TNF-antagonists used, prior primary nonresponse to TNF-antagonist, and prior thiopurine or methotrexate (MTX) intolerance. Those with prior intolerance to both thiopurine and MTX were excluded. Treatment response was categorised with the Physician Global Assessment (PGA). Using Cox proportional hazard models, we adjusted for type of IM used (thiopurine vs. MTX) and compared cumulative rates of clinical remission (complete resolution of IBD-related symptoms), steroid-free remission (on steroids at baseline, tapered off, no repeat steroid prescription for 4 weeks), and endoscopic healing (absence of ulcers or erosions for CD and Mayo endoscopic subscore of 0 or 1 for UC). Hazard ratios (HRs) and 95% confidence intervals (CIs) are reported for VDZ combination vs. monotherapy. The propensity score model had modest accuracy for predicting treatment status (area under curve 0.68). Of 1087 patients, 718 were included after matching (n = 450 CD, 47% male, median age 35 years). CD patients treated with VDZ combination therapy had significantly higher cumulative 12-month rates of clinical remission (38% vs. 32%; HR 2.30, 95% CI 1.12–4.74), and numerically but not statistically significant higher 12-month rates of steroid-free remission (31% vs. 17%; HR 2.70, 95% CI 0.78–9.34). Rates of endoscopic healing were comparable (43% vs. 43%; HR 1.18, 95% CI 0.45–2.77). UC patients treated with VDZ combination therapy had significantly higher cumulative 12-month rates of steroid-free remission (47% vs. 30%; HR 4.10, 95% CI 1.06–15.90) and numerically but not statistically significant higher 12-month rates of clinical remission (51% vs. 43%; HR 1.55, 95% CI 0.65–3.70) and endoscopic healing (54% vs. 41%; HR 1.59, 95% CI 0.37–6.70). After accounting for measurable disease and patient-specific characteristics that may impact biologic effectiveness and concomitant IM use, we observed significantly higher rates of clinical remission for CD and steroid-free remission for UC. Randomised controlled trial data are needed to assess the impact of concomitant IM use for VDZ. Statistical analyses conducted at University of California, San Diego. Research funded in part by Takeda.
Supplementary Figures 3 - 4 from mTOR Inhibition Improves Antitumor Effects of Vaccination with Antigen-Encoding RNA (2023)

&lt;p&gt;PDF file - 1350K, Description of effects of Rapamycin on blood hematogram values and on frequencies of antigen specific T cells.&lt;/p&gt;
Thioredoxin-interacting Protein (Txnip) Is a Critical Regulator of Hepatic Glucose Production (2007)

Thioredoxin-interacting protein (Txnip) has been recently described as a possible link between cellular redox state and metabolism; Txnip binds thioredoxin and inhibits its disulfide reductase activity in vitro, while a naturally occurring strain of Txnip-deficient mice has hyperlipidemia, hypoglycemia, and ketosis exacerbated by fasting. We generated Txnip-null mice to investigate the role of Txnip in glucose homeostasis. Txnip-null mice were hypoglycemic, hypoinsulinemic, and had blunted glucose production following a glucagon challenge, consistent with a central liver glucose-handling defect. Glucose release from isolated Txnip-null hepatocytes was 2-fold lower than wild-type hepatocytes, whereas beta-hydroxybutyrate release was increased 2-fold, supporting an intrinsic defect in hepatocyte glucose metabolism. While hepatocyte-specific gene deletion of Txnip did not alter glucose clearance compared with littermate controls, Txnip expression in the liver was required for maintaining normal fasting glycemia and glucose production. In addition, hepatic overexpression of a Txnip transgene in wild-type mice resulted in elevated serum glucose levels and decreased ketone levels. Liver homogenates from Txnip-null mice had no significant differences in the glutathione oxidation state or in the amount of available thioredoxin. However, overexpression of wild-type Txnip in Txnip-null hepatocytes rescued cellular glucose production, whereas overexpression of a C247S mutant Txnip, which does not bind thioredoxin, had no effect. These data demonstrate that Txnip is required for normal glucose homeostasis in the liver. While available thioredoxin is not changed in Txnip-null mice, the effects of Txnip on glucose homeostasis are abolished by a single cysteine mutation that inhibits binding to thioredoxin.
An efficient pipelined parallel architecture for blocking effect removal in HDTV (1997)

This paper presents an efficient architecture for blocking effect removal in HDTV. Since there is a large amount of image signal for processing in digital HDTV, the memory size and fast operation have been the main concerns of the DSP (digital signal processing) architectures. To reduce the size of the memory, the memory is partitioned into many memory banks. This makes it possible to access the memory concurrently. Also, to improve the operation speed, a pipelined parallel architecture and a memory scheduling technique are adopted. Since multiplications and divisions are time-critical, these operations are replaced with shiftings. Therefore this architecture is very fast and uses small size memory banks, and this makes it possible to realize a real-time signal processor.
ChemInform Abstract: AN INVESTIGATION OF THE CHEMISTRY OF PHENYLSULFONYLCYCLOPENTADIENE (1984)

Abstract Cyclopentadien (I) wird nach Literaturverfahren in das Chlorcyclopenten (II) übergeführt und dieses unter HCl‐Abspaltung zur Titelverbindung (III) umgesetzt.
Abstracts (1999)

We examined the dynamics of connexins, E-cadherin and α-catenin during gap-junction disassembly and assembly in regenerating hepatocytes by immunofluorescence microscopy, and immunogold-electron microscopy using frozen-thin sections and SDS-digested freeze-fracture replicas.The present findings suggested that during the disappearance of gap junctions, most of the gap junction plaques are broken up into smaller aggregates, and then the gap junction proteins are removed from the cell membrane, but some of the connexons or connexins remain dispersed in the plane of membrane as pure morphologically indistinguishable intramembrane proteins.Double-immunogold electron microscopy using a polyclonal antibody for connexins and a monoclonal antibody for E-cadherin or a-catenin revealed co-localization of these molecules on the cell-to-cell contact sites during the reappearance of gap junction plaques.This implies that, at least in the regenerating hepatocytes, the cadherin-catenin complexes-mediated cell-to-cell contact sites act as foci for gap junction formation.In addition, connexinsimmunoreactivity was also observed along tight junctional strands, suggesting that the gap junction may also form along the tight junctions.
Effects of Helicobacter pylori colonisation on the adherent gastric mucus barrier (1997)

Conference Article| May 01 1997 Effects of Helicobacter pylori colonisation on the adherent gastric mucus barrier LINDSEY OLIVER; LINDSEY OLIVER 1Department of Physiological Sciences, The Medical School, University of Newcastle upon Tyne, NE2 4HH, UK Search for other works by this author on: This Site PubMed Google Scholar JULIA L NEWTON; JULIA L NEWTON 1Department of Physiological Sciences, The Medical School, University of Newcastle upon Tyne, NE2 4HH, UK Search for other works by this author on: This Site PubMed Google Scholar NICOLA JORDAN; NICOLA JORDAN 1Department of Physiological Sciences, The Medical School, University of Newcastle upon Tyne, NE2 4HH, UK Search for other works by this author on: This Site PubMed Google Scholar PAUL GODDARD; PAUL GODDARD *Reckitt and Colman Products Ltd., Dansom Lane, Hull, HU8 7DS, UK Search for other works by this author on: This Site PubMed Google Scholar PETER DETTMAR; PETER DETTMAR *Reckitt and Colman Products Ltd., Dansom Lane, Hull, HU8 7DS, UK Search for other works by this author on: This Site PubMed Google Scholar JEFFREY P PEARSON; JEFFREY P PEARSON 1Department of Physiological Sciences, The Medical School, University of Newcastle upon Tyne, NE2 4HH, UK Search for other works by this author on: This Site PubMed Google Scholar ADRIAN ALLEN ADRIAN ALLEN 1Department of Physiological Sciences, The Medical School, University of Newcastle upon Tyne, NE2 4HH, UK Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1997) 25 (2): 372S. https://doi.org/10.1042/bst025372s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation LINDSEY OLIVER, JULIA L NEWTON, NICOLA JORDAN, PAUL GODDARD, PETER DETTMAR, JEFFREY P PEARSON, ADRIAN ALLEN; Effects of Helicobacter pylori colonisation on the adherent gastric mucus barrier. Biochem Soc Trans 1 May 1997; 25 (2): 372S. doi: https://doi.org/10.1042/bst025372s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1997 Biochemical Society1997 Article PDF first page preview Close Modal You do not currently have access to this content.