gebhart/patrepeval huggingface dataset:
Chapter 13 – Intel Corporation—Intel IXP2400 Network Processor: A Second-Generation Intel NPU (2003)

Publisher Summary
Next generation access and edge equipment requires flexible programming, high performance, low power consumption, and small real estate. In context to this, Intel has developed a next-generation network processor, the IXP2400, which is optimized to meet these requirements. The Intel IXP2400 network processor delivers a new level of intelligence and performance for access and edge applications, enabling the realization of quality of service (QoS), enforcement of service-level agreements (SLAs), and traffic engineering at OC-48/2 .5 Gbps and 4 Gbps data rates. The flexible media interface allows a variety of media devices, ranging from OC3 to OC48 speeds to be connected without logic to the IXP2400 for easier design and lower system cost. These capabilities essentially allow OEMs and service providers to offer differentiated and tiered services to their customers while efficiently managing their network resources and bandwidth. The performance and flexibility of the IXP2400 makes it desirable for a wide variety of high-performance applications such as multiservice switches, DSLAMs (DSL access multiplexers), CMTS (cable modem termination system) equipment, 2.5G and 3G wireless infrastructure, and layer 4-7 switches.
Inhibition of the Transcription Factor RUNX1 Causes Glycosyltransferase a Repression (2017)

Abstract Background: The ABO blood group system is unequivocally the most important in clinical transfusion medicine. Furthermore ABO is implicated in the development of a number of human diseases. The ABO antigens are not confined to RBCs but are widely expressed in a variety of human cells and tissues. Thus, ABO matching is critical not only in blood transfusion but also in cell, tissue and organ transplantation. The molecular genetic basis of the ABO system has been known since 1990. However, despite extensive investigations about regulation of ABO blood group receptor expression, the mechanism is not fully resolved. Previously we found that miRNAs plays a critical role in regulation of ABO blood group antigen. Numerous miRNAs which were up- or downregulated in RBCs of blood group O and of heterozygous genotypes as compared to homozygous genotype possess potential binding sites in the 3'UTR of several transcription factors, such as SP1 and RUNX1. Here we show that silencing of the transcription factor RUNX1 leads to downregulation of blood group A antigen. Methods: We performed knockdown experiments for RUNX1 by lentiviral gene transfer of shRNA in primary hematopoietic stem cells (HSCs) and analyzed blood group A-antigen expression using different method, including flow cytometry, western blot and qPCR. Result: Knockdown of RUNX1 in HSCs leads to a 10-20% reduction of blood group A positive erythroid cells and a 30-40% reduction of blood group A antigens per cell in differentiated RBCs. Furthermore, microarray analysis showed a significant increase of miR-215-5p and miR-192-5p in RBCs of blood group O as compared to homozygous genotype. RUNX1 is known to be a target gene for these miRNAs. Conclusion: Glycosyltransferase A and B expression is regulated by different miRNAs, via simultaneously targeting of the transcription factors SP1 and Runx1 and glycosyltransferase A and B mRNA. The knowledge of the role of microRNAs and the transcription factors SP1 and RUNX1 in the expression of blood group antigens may be extended to other blood groups (Rhesus, Kell, Duffy) and may open the door for therapeutic interventions in diseases where blood group receptors promote disease pathology. Disclosures No relevant conflicts of interest to declare.
NDE Developments for Composite Structures (2006)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Richard H. Bossi; NDE Developments for Composite Structures. AIP Conf. Proc. 6 March 2006; 820 (1): 965–971. https://doi.org/10.1063/1.2184629 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Characteristics of the USLP based beacon for laser beam control (2018)

Effective performance of laser systems intended for power delivery on a distant object requires an adaptive optics system to correct the laser beam distortions caused by atmospheric perturbations along the propagation path. The turbulence-induced effects are responsible for beam wobbling, wandering, and intensity scintillation, resulting in degradation of the beam quality and decline of the power density on the target. Adaptive optics methods are used to compensate these negative effects. In its turn, operation of the Adaptive Optics System (AOS) requires a reference wave that can be generated by the beacon on the target. This report discusses the requirements to the beacon that can support optimal correction of the wavefront. Post-processing of the beacon-generated light field enables retrieval and detailed characterization of the turbulence-perturbed wavefront &mdash; data essential to control the adaptive optics module of a high-power laser system.
Skin Hair Removal for 2D Psoriasis Images (2015)

Presence of hair in psoriasis skin images may adversely affect the extraction of the features required for computer aided analysis, thus compromise the detection and diagnostic results. Therefore, for the diagnosis of psoriasis to be accurate, it is vitally important to remove hair, if it exists, from images in the preprocessing stage. This paper presents, for the first time, a hair detection and removal algorithm for 2D psoriasis images. The hair removal process starts with a markers removal algorithm, where the shape features are extracted from the binary input image. The outcome of this step is removal of all objects that obscure the image lesions such that the output image contains psoriasis lesions and normal skin only. Next, the dark hair in the skin is identified using contrast enhancement method and morphological operations. Finally, image interpolation is performed to replace the hair pixels with hair free neighbouring pixels values through image inpainting. The proposed algorithm is tested on 64 psoriasis images acquired from the Royal Melbourne Hospital, Victoria, Australia. Experimental results demonstrate that the algorithm is highly accurate and effective. In addition, the widely used hair removal software DullRazor <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">®</sup> is used on the same 64 images for comparison. The results show that our proposed algorithm performs quite well and is more adapt to psoriasis images. The method is more effective because it overcomes the problem of removing skin hair without affecting the intensity or texture features of the lesions.
Sub-Nyquist Sampling (2011)

In this article, we review sampling strategies that target reduction of the ADC rate below Nyquist. Our survey covers classic works from the early 1950s through recent publications from the past several years. The prime focus is bridging theory and practice, that is, to pinpoint the potential of sub-Nyquist strategies to emerge from the math to the hardware. In this spirit, we integrate contemporary theoretical viewpoints, which study signal modeling in a union of subspaces, together with a taste of practical aspects, more specifically how the avant-garde modalities boil down to concrete signal processing systems. Our hope is that this presentation style will attract the interest of both researchers and engineers with the aim of promoting the sub-Nyquist premise into practical applications while encouraging further research into this exciting new frontier.
The relationship of the transmural extent of T2-edema compared with the transmural extent of infarction: implications for the assessment of the area-at-risk (2011)

Background It has been reported that hyperintensity on T2W-CMR represents the area-at-risk. This conclusion is based upon the observation that the region of T2-hyperintensity is always larger than region of infarction. However, differences in measured size may be due to many factors, including the choice of different image intensity thresholds (Nat Rev Cardiol. 2010 Oct;7(10):547-9.). Additionally, basic physiology studies have established that the area-at-risk is not simply larger than the region of infarction, but is nearly always transmural regardless of the transmurality of infarct size. The relationship between the transmural extent of T2-hyperintensity and the transmural extent of infarction is unknown.
Nanotechnology approaches for personalized treatment of multidrug resistant cancers (2013)

The efficacy of chemotherapy is substantially limited by the resistance of cancer cells to anticancer drugs that fluctuates significantly in different patients. Under identical chemotherapeutic protocols, some patients may receive relatively ineffective doses of anticancer agents while other individuals obtain excessive amounts of drugs that induce severe adverse side effects on healthy tissues. The current review is focused on an individualized selection of drugs and targets to suppress multidrug resistance. Such selection is based on the molecular characteristics of a tumor from an individual patient that can potentially improve the treatment outcome and bring us closer to an era of personalized medicine.
Development and Reliability of Retinal Arteriolar Central Light Reflex Quantification System: A New Approach for Severity Grading (2014)

Quantitative assessment of retinal arteriolar wall opacification is a reliable method using a new computer-assisted system. This new CRR measurement system is a potentially useful tool to study retinal arteriolar abnormalities with systemic diseases.
Frequency Ratio Measurement of Hg and Sr Optical Lattice Clocks (2015)

A Hg-based optical lattice clock has a potential to realize 10−18 -level uncertainty because of its low susceptibility to the blackbody radiation [1]. Moreover, a relatively large nuclear charge &#x01d44d; of Hg allows exploring the variation of the fine-structure constant [2] by referencing, e.g., Sr clocks with smaller &#x01d44d;. After the first demonstration of laser cooling of neutral Hg [1], the determination of the magic wavelength [3] and an absolute frequency measurement of the clock transition [4] have been reported.
Multi-antenna near field cancellation duplexing for concurrent transmit and receive (2011)

Concurrent transmit and receive with multiple antennas is demonstrated through near field cancellation. Full-duplex operation is possible through cancellation of the transmit signal at the receiver as much as 50dB. By exploiting symmetry in an array of antennas, a centrally located receiver is able to operate without saturation in the presence of high power transmit signals. The transmitters are able to provide spatial diversity and 360-degree azimuthal coverage while maintaining the requisite cancellation. We demonstrate the basic concept and then explore the criteria within the RF components needed to maintain suitable cancellation.
Voltage-Gated Sodium Channel Modulation by a New Spider Toxin Ssp1a Isolated From an Australian Theraphosid (2021)

Given the important role of voltage-gated sodium (Na<sub>V</sub>) channel-modulating spider toxins in elucidating the function, pharmacology, and mechanism of action of therapeutically relevant Na<sub>V</sub> channels, we screened the venom from Australian theraphosid species against the human pain target hNa<sub>V</sub>1.7. Using assay-guided fractionation, we isolated a 33-residue inhibitor cystine knot (ICK) peptide (Ssp1a) belonging to the NaSpTx1 family. Recombinant Ssp1a (rSsp1a) inhibited neuronal hNa<sub>V</sub> subtypes with a rank order of potency hNa<sub>V</sub>1.7 > 1.6 > 1.2 > 1.3 > 1.1. rSsp1a inhibited hNa<sub>V</sub>1.7, hNa<sub>V</sub>1.2 and hNa<sub>V</sub>1.3 without significantly altering the voltage-dependence of activation, inactivation, or delay in recovery from inactivation. However, rSsp1a demonstrated voltage-dependent inhibition at hNa<sub>V</sub>1.7 and rSsp1a-bound hNa<sub>V</sub>1.7 opened at extreme depolarizations, suggesting rSsp1a likely interacted with voltage-sensing domain II (VSD II) of hNa<sub>V</sub>1.7 to trap the channel in its resting state. Nuclear magnetic resonance spectroscopy revealed key structural features of Ssp1a, including an amphipathic surface with hydrophobic and charged patches shown by docking studies to comprise the interacting surface. This study provides the basis for future structure-function studies to guide the development of subtype selective inhibitors.
A pH-controlled fed-batch process can overcome inhibition by formate in NADH-dependent enzymatic reductions using formate dehydrogenase-catalyzed coenzyme regeneration (1998)

The NAD-dependent, formate dehydrogenase-catalyzed oxidation of formate anion into CO2 is known as the method for the regeneration of NADH in reductive enzymatic syntheses. Inhibition by formate and inactivation by alkaline pH-shift that occurs when oxidation of formate is carried out at pH approximately 7.0 may, however, hamper the efficient application of this NADH recycling reaction. Here, we have devised a fed-batch process using pH-controlled feeding of formic acid that can overcome enzyme inhibition and inactivation. The reaction pH is thus kept constant by addition of acid, and formate dehydrogenase is supplied continuously with substrate as required, but the concentration of formate is maintained at a constant, non- or weakly inhibitory level throughout the enzymatic conversion, thus enabling a particular NADH-dependent dehydrogenase to operate stably and at high reaction rates. For xylitol production from xylose using yeast xylose reductase (Ki,Formate 182 mM), a fed-batch conversion of 0.5M xylose yielded productivities of 2.8 g (L h)-1 that are three-fold improved when contrasted to a conventional batch reaction that employed equal initial concentrations of xylose and formate.
Adaptively Weighted Multi-task Deep Network for Person Attribute Classification (2017)

Multi-task learning aims to boost the performance of multiple prediction tasks by appropriately sharing relevant information among them. However, it always suffers from the negative transfer problem. And due to the diverse learning difficulties and convergence rates of different tasks, jointly optimizing multiple tasks is very challenging. To solve these problems, we present a weighted multi-task deep convolutional neural network for person attribute analysis. A novel validation loss trend algorithm is, for the first time proposed to dynamically and adaptively update the weight for learning each task in the training process. Extensive experiments on CelebA, Market-1501 attribute and Duke attribute datasets clearly show that state-of-the-art performance is obtained; and this validates the effectiveness of our proposed framework.
Development of 99mTc-labeled esmolol derivative (99mTc-EDA-ESM) as a novel β1-adrenoceptor SPECT radiotracer (2013)

134 Objectives The failing human heart is related with a selective reduction in β1-adrenoceptor. We designed radiolabeled esmolol, is known to be a cardioselective β1 receptor blocker in the sympathetic nervous system. A new 99mTc-labeld esmolol derivative (99mTc-EDA-ESM) was prepared and its binding and biokinetic characteristics in normal rat for the noninvasive measurement of cardiac β1-adrenoceptor density. Methods 99mTc-EDA-ESM was prepared by reacting 99mTcO4- with the precursor in the presence of SnF2, ascorbic acid, and mannitol at room temperature for 30 sec. To optimize the labeling condition, a variety of attempts were investigated with different reducing agents and anti-oxidants. For assessment of heart and major organ uptake of radiotracer, serial SPECT/CT images of 99mTc-EDA-ESM (74 MBq) in normal rat were obtained in 12 projections over a 10-min period and blocking experiment was performed with esmolol or atenolol. Results 99mTc-EDA-ESM was synthesized in 95% radiochemical yield with over 98% of radiochemical purity. Mass and NMR data of Re-EDA-ESM were used for the speculation of 99mTc-EDA-ESM structure. In serial SPECT images, radiotracer showed high accumulation in the heart and kidneys, while radio-uptake was relatively low in the liver and lung. ROIs were drawn in the lung, the liver and the heart, and their radioactivity were shown as 0.38±0.04, 1.10±0.20, and 1.88±0.20%ID/g at 5 min post-injection and 0.21±0.03, 0.85±0.22, and 1.02±0.15%ID/g at 25 min post-injection, respectively. In vivo blocking with excess esmolol or atenolol resulted in significantly reduced radioactivity uptake in the heart by 92% and 76%, respectively. Conclusions Our results demonstrate that 99mTc-EDA-ESM exhibits specific β1-adrenergic receptor binding and favorable in vivo biokinetic characteristics, making it a promising SPECT radiotracer for the imaging of β1-adrenoceptors.
Measurement of $CP$ asymmetry in $D^0 \to K^0_S K^0_S$ decays (2021)

A measurement of the CP asymmetry in $D^0 \to K^0_S K^0_S$ decays is reported, based on a data sample of proton-proton collisions collected by the LHCb experiment from 2015 to 2018, corresponding to an integrated luminosity of 6 $fb^{-1}$. The flavor of the D0 candidate is determined using the charge of the $D^{*±}$ meson, from which the decay is required to originate. The $D^0 → K^+ K^-$ decay is used as a calibration channel. The time-integrated CP asymmetry for the $D^0 \to K^0_S K^0_S$ mode is measured to be $\mathcal{A}^{CP}(D^0 \to K^0_S K^0_S)=(-3.1±1.2±0.4±0.2)$, where the first uncertainty is statistical, the second is systematic, and the third is due to the uncertainty on the CP asymmetry of the calibration channel. This is the most precise determination of this quantity to date.
Electron transfer in metal-dioxygen adducts (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleElectron transfer in metal-dioxygen adductsA. B. P. Lever, G. A. Ozin, and Harry B. GrayCite this: Inorg. Chem. 1980, 19, 6, 1823–1824Publication Date (Print):June 1, 1980Publication History Published online1 May 2002Published inissue 1 June 1980https://pubs.acs.org/doi/10.1021/ic50208a085https://doi.org/10.1021/ic50208a085research-articleACS PublicationsRequest reuse permissionsArticle Views172Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A variational dynamic programming approach to robot path planning with a distance-safety criterion (1987)

http://deepblue.lib.umich.edu/bitstream/2027.42/7820/5/bad2453.0001.001.pdf
The synthesis and polymerization behaviour of silicon-bridged [1]- and [2]ferrocenophanes with sterically demanding trimethylsilyl substituents attached to the cyclopentadienyl rings (1995)

The silicon-bridged [1]ferrocenophane Fe(η-C 5 H 3 SiMe 3 ) 2 (SiMe 2 ) (5) was synthesized via the reaction of Li 2 [Fe(η-C 5 H 3 SiMe 3 ) 2 ]•tmeda (tmeda = tetramethylethylenediamine) with Me 2 SiCl 2 in hexanes. The disilane-bridged [2]ferrocenophane Fe(η-C 5 H 3 SiMe 3 ) 2 (Si 2 Me 4 ) (7) was prepared using a similar route from the disilane ClMe 2 SiSiMe 2 Cl. Despite the presence of sterically demanding SiMe 3 substituents on the cyclopentadienyl rings, compound 5 was found to undergo thermal ring-opening polymerization at 170 °C to produce very soluble, high molecular weight poly(ferrocenylsilane) 6 with M w = 1.4 × 10 5 , M n = 8.4 × 10 4 . However, the [2]ferrocenophane 7 was found to be resistant to thermal ring-opening polymerization even at 350 °C and decomposed above 380 °C. A single-crystal X-ray diffraction study of 7 revealed that the steric interactions between the bulky SiMe 3 groups are relieved by a significant twisting of the disilane bridge with respect to the plane defined by the centroids of the cyclopentadienyl ligands and the metal atom. The angle between the planes of the cyclopentadienyl rings in 7 was found to be 5.4(6)°, slightly greater than that in the non-silylated analogue Fe(η-C 5 H 4 ) 2 (Si 2 Me 4 ) (4a) (4.19(2)°), and dramatically less than the corresponding tilt angle of the strained, polymerizable, silicon-bridged [1]ferrocenophane Fe(η-C 5 H 4 ) 2 (SiMe 2 ) (1) (20.8(5)°). The length of the Si—Si bond in 7 (2.342(3) Å) was found to be close to the sum of the covalent radii (2.34 Å). Crystals of 7 are monoclinic, space group C2/c, with a = 23.689(3) Å, b = 11.174(1) Å, c = 31.027(3) Å, β = 109.16(1)°, V = 7758(2) Å 3 , and Z = 12. Keywords: ring-opening polymerization, ferrocenophane, organometallic polymers.
The Biomechanical Effects of Fatigue on the Porcine Bioprosthetic Heart Valve (2001)

Characterization of the mechanisms of degeneration of porcine bioprosthetic heart valves (BHV) during long-term cyclic loading is required for predicting and ultimately preventing their failure. Isolation of purely mechanical effects from host biological ones is a necessary first step in understanding the fatigue process as a whole. Thus, in this review we focus on mechanical factors alone as a means of isolating their role in altering biomechanical properties and ultimately their contribution to the fatigue damage process. Mechanical evaluations included tension controlled biaxial, 3-point flexural, and uniaxial failure tests performed on cuspal tissue following 0, 50, 100, 200, and 300 x 10(6) in vitro accelerated test cycles. Overall, biaxial mechanical results indicate a decreasing radial extensibility that can be explained by stiffening of the effective collagen fiber network as well as a small decrease in the splay of the collagen fibers. Moreover, these results suggest that the loss in flexural rigidity with fatigue that we have previously measured (ASAIO 1999; 45:59-63) may not be because of loss of collagen stiffness alone, but also to fiber debonding and degradation of the amorphous extracellular matrix. We discuss the implications of these results that point toward the development of chemical-treatment methods that seek to maintain the integrity of the amorphous extracellular matrix to ultimately extend BHV long-term durability.
Behavior of Different Physiological Markers in Relation to Computer Based Mental Activities (2018)

Mental stress is the response of human body subjected to any mental activities.Jobs, study, and major life changes can be classified as mental stressors, humanscan be normally subjected to mental stress. However, paying attention andmonitoring minor and major mental stress activities assist in protection from mentalhealth risk and control human’s performance.Many researchers studied different responses from mental activities to identify themost related marker in relation to the subjected mental activity. However, it is still achallenge. One of the most frequently used computer based mental tasks is Stroopcolor test that shows a great influence on subjects’ responses. In this paper,experimental comparison is applied between different responses of physiologicalmarkers in relation to laboratory mental stressor based on Stroop color test.