gebhart/patrepeval huggingface dataset:
Demonstration and Validation of Trivalent Aluminum Pretreatment on U.S. Navy S-3 Aircraft (1999)

Abstract : A Trivalent Chromium Pretreatment (TCP) demonstration and validation program is currently being executed for Naval Aviation platforms. The aft section of two S-3 aircraft has been treated using a spray-on process at the Naval Aviation Depot (NADEP) at North Island, California. The coating system on these aircraft will be evaluated for corrosion performance and paint adhesion at regular intervals. The S-3s will be in service during their evaluation period. Trivalent Chromium Pretreatment demonstration and validation efforts are also underway for aircraft stationed at NADEP Cherry Point, North Carolina and NADEP Jacksonville, Florida. A thorough demonstration and validation of TCP will ensure an efficient transition to the fleet. Other opportunities are being solicited for demonstration and validation TCP throughout the Department of Defense, the National Aeronautical and Space Administration, and original equipment manufacturers.
Anti-inflammatory effect of enzymatic hydrolysates fromStyela clavaflesh tissue in lipopolysaccharide-stimulated RAW 264.7 macrophages andin vivozebrafish model (2015)

The results of this study suggested that hydrolysates derived from S. clava flesh tissue would be new anti-inflammation materials in functional resources.
Intravenous immunoglobulins for the treatment of infections in patients with haematological cancers (2016)

The completion of the last task is overdue for more than one year. New authors are being sought to take over this protocol.
Magnetic Coupling in ESP Applications (2020)

Abstract This paper presents a feasibility assessment of eliminating the protector of an electric submersible pump (ESP) by transferring the torque from the motor to the pump using a magnetic coupling, thereby allowing the motor to be hermetically sealed from the wellbore fluids in the operating environment. The paper also briefly discusses means of handling the motor oil expansion as well as the pump axial thrust. The industry seeks to enhance ESP reliability by designing protectorless ESPs. This requires new techniques to handle torque transfer, motor oil volume change and pump axial thrust, critical functions that a typical protector section performs. Magnetic coupling is a potential method to handle motor/pump torque transfer. For ESP applications, a radial magnetic flux type of coupling is considered. Finite Element software is used to identify the appropriate magnet materials, estimate the coupling dimensions, and predict the coupling performance under transient loads. A sensitivity study is also included to evaluate dimensional variations for different power requirements under different pump rotational speeds. The analysis identifies two permanent magnet (PM) materials to be appropriate for the magnetic coupling. The length of the coupling is determined for three values of the transmitted power (100, 200 and 300 HP) when operating at three different speeds (3500, 6000 and 10000 rpm). The results show that the magnetic coupling length ranges from 0.95 m to 3.7 m for the considered power range (100 to 300 HP) when operating at a speed of 3500 rpm. The length of the coupling is found to be in the range from 0.65 m to 2.55 m for the speed of 6000 rpm and from 0.4 m to 1.8 m for the speed of 10000 rpm. Mechanical integrity analysis shows that only the case of 100 HP/10000 rpm operates at a subcritical condition, where the predicted total eccentricity has a permissible value. All other operating conditions are supercritical and the whirling deflections of the shaft are likely to exceed the available space within the air-gap. To make the coupling design feasible for these operating conditions, the use of intermediate radial bearings are necessary, which can be challenging in the mechanical implementation and assembly. This study represents the first systematic and comprehensive attempt in the ESP industry to investigate and assess the feasibility of using a magnetic coupling to replace the conventional protector section of an ESP system. It shows that under low power requirement and high operational speeds, a magnetic coupling is feasible. For other conditions, additional challenges need to be addressed to stabilize the coupling and achieve longevity with the coupling design.
Class-Incremental Learning with Strong Pre-trained Models (2022)

Class-incremental learning (CIL) has been widely studied under the setting of starting from a small number of classes (base classes). Instead, we explore an understudied real-world setting of CIL that starts with a strong model pre-trained on a large number of base classes. We hypothesize that a strong base model can provide a good representation for novel classes and incremental learning can be done with small adaptations. We propose a 2-stage training scheme, i) feature augmentation -- cloning part of the backbone and fine-tuning it on the novel data, and ii) fusion -- combining the base and novel classifiers into a unified classifier. Experiments show that the proposed method significantly outperforms state-of-the-art CIL methods on the large-scale ImageNet dataset (e.g. +10% overall accuracy than the best). We also propose and analyze understudied practical CIL scenarios, such as base-novel overlap with distribution shift. Our proposed method is robust and generalizes to all analyzed CIL settings. Code is available at https://github.com/amazon-research/sp-cil.
High thermal conductivity in soft elastomers with elongated liquid metal inclusions (2017)

Soft dielectric materials typically exhibit poor heat transfer properties due to the dynamics of phonon transport, which constrain thermal conductivity (<i>k</i>) to decrease monotonically with decreasing elastic modulus (<i>E</i>). This thermal-mechanical trade-off is limiting for wearable computing, soft robotics, and other emerging applications that require materials with both high thermal conductivity and low mechanical stiffness. Here, we overcome this constraint with an electrically insulating composite that exhibits an unprecedented combination of metal-like thermal conductivity, an elastic compliance similar to soft biological tissue (Young's modulus < 100 kPa), and the capability to undergo extreme deformations (>600% strain). By incorporating liquid metal (LM) microdroplets into a soft elastomer, we achieve a ∼25× increase in thermal conductivity (4.7 ± 0.2 W⋅m<sup>-1</sup>⋅K<sup>-1</sup>) over the base polymer (0.20 ± 0.01 W⋅m<sup>-1</sup>·K<sup>-1</sup>) under stress-free conditions and a ∼50× increase (9.8 ± 0.8 W⋅m<sup>-1</sup>·K<sup>-1</sup>) when strained. This exceptional combination of thermal and mechanical properties is enabled by a unique thermal-mechanical coupling that exploits the deformability of the LM inclusions to create thermally conductive pathways in situ. Moreover, these materials offer possibilities for passive heat exchange in stretchable electronics and bioinspired robotics, which we demonstrate through the rapid heat dissipation of an elastomer-mounted extreme high-power LED lamp and a swimming soft robot.
Design, Synthesis, and Biochemical Characterization of Non-Native Antagonists of the Pseudomonas aeruginosa Quorum Sensing Receptor LasR with Nanomolar IC50 Values (2020)

Quorum sensing (QS), a bacterial cell-to-cell communication system mediated by small molecules and peptides, has received significant interest as a potential target to block infection. The common pathogen <i>Pseudomonas aeruginosa</i> uses QS to regulate many of its virulence phenotypes at high cell densities, and the LasR QS receptor plays a critical role in this process. Small molecule tools that inhibit LasR activity would serve to illuminate its role in <i>P. aeruginosa</i> virulence, but we currently lack highly potent and selective LasR antagonists, despite considerable research in this area. V-06-018, an abiotic small molecule discovered in a high-throughput screen, represents one of the most potent known LasR antagonists but has seen little study since its initial report. Herein, we report a systematic study of the structure-activity relationships (SARs) that govern LasR antagonism by V-06-018. We synthesized a focused library of V-06-018 derivatives and evaluated the library for bioactivity using a variety of cell-based LasR reporter systems. The SAR trends revealed by these experiments allowed us to design probes with 10-fold greater potency than that of V-06-018 and 100-fold greater potency than other commonly used <i>N</i>-acyl-l-homoserine lactone (AHL)-based LasR antagonists, along with high selectivities for LasR. Biochemical experiments to probe the mechanism of antagonism by V-06-018 and its analogues support these compounds interacting with the native ligand-binding site in LasR and, at least in part, stabilizing an inactive form of the protein. The compounds described herein are the most potent and efficacious antagonists of LasR known and represent robust probes both for characterizing the mechanisms of LuxR-type QS and for chemical biology research in general in the growing QS field.
TAPP Adaptors Control B Cell Metabolism by Modulating the Phosphatidylinositol 3-Kinase Signaling Pathway: A Novel Regulatory Circuit Preventing Autoimmunity (2018)

Class I PI3K enzymes play critical roles in B cell activation by phosphorylating plasma membrane lipids to generate two distinct phosphoinositide (PI) products, PI(3,4,5)P3 and PI(3,4)P2. These PIs each bind distinct but overlapping sets of intracellular proteins that control cell survival, cytoskeletal reorganization, and metabolic activity. The tandem PH domain containing proteins (TAPPs) bind with high specificity to PI(3,4)P2, and their genetic uncoupling from PI(3,4)P2 in TAPP knock in (KI) mice was previously found to cause chronic B cell activation, abnormal germinal centers (GCs), and autoimmunity. In this article, we find that TAPPs provide feedback regulation affecting PI3K signaling and metabolic activation of B cells. Upon activation, TAPP KI B cells show enhanced metabolic activity associated with increased extracellular acidification rate, increased expression of glucose transporter GLUT1, and increased glucose uptake. TAPP KI B cells show markedly increased activation of the PI3K-regulated kinases Akt, GSK3β, and p70-S6K. Conversely, overexpression of the C-terminal TAPP PH domains in B cells can inhibit Akt phosphorylation by a mechanism requiring the TAPP PI(3,4)P2-binding pocket. Inhibition of the PI3K pathway in TAPP KI B cells reduced GLUT1 expression and glucose uptake, whereas inhibition of Akt alone was not sufficient to normalize these responses. TAPP KI GC B cells also show increased GLUT1 and glucose uptake, and treatment with the inhibitor of glycolysis 2-deoxy-D-glucose reduced chronic GC responses and autoantibody production within these mice. Our findings show that TAPP-PI(3,4)P2 interaction controls activation of glycolysis and highlights the significance of this pathway for B cell activation, GC responses, and autoimmunity.
Can LTE-A Support Real-Time Smart Meter Traffic in the Smart Grid? (2021)

The chapter investigates the scheduling load added on a long-term evolution (LTE) and/or LTE-Advanced (LTEA) network when automatic meter reading (AMR) in advanced metering infrastructures (AMI) is performed using internet of things (IoT) deployments of smart meters in the smart grid. First, radio resource management algorithms to perform dynamic scheduling of the meter transmissions are proposed and shown to allow the accommodation of a large number of smart meters within a limited coverage area. Then, potential techniques for reducing the signaling load between the meters and base stations are proposed and analyzed. Afterwards, advanced concepts from LTE-A, namely carrier aggregation (CA) and relay stations (RSs) are investigated in conjunction with the proposed algorithms in order to accommodate a larger number of smart meters without disturbing cellular communications.
3D Maps of Mineral Composition and Hydroxyapatite Orientation in Fossil Bone Samples Obtained by X-ray Diffraction Computed Tomography (2018)

Whether hydroxyapatite (HA) orientation in fossilised bone samples can be non-destructively retrieved and used to determine the arrangement of the bone matrix and the location of muscle attachments (entheses), is a question of high relevance to palaeontology, as it facilitates a detailed understanding of the (micro-)anatomy of extinct species with no damage to the precious fossil specimens. Here, we report studies of two fossil bone samples, specifically the tibia of a 300-million-year-old tetrapod, Discosauriscus austriacus, and the humerus of a 370-million-year-old lobe-finned fish, Eusthenopteron foordi, using XRD-CT - a combination of X-ray diffraction (XRD) and computed tomography (CT). Reconstructed 3D images showing the spatial mineral distributions and the local orientation of HA were obtained. For Discosauriscus austriacus, details of the muscle attachments could be discerned. For Eusthenopteron foordi, the gross details of the preferred orientation of HA were deduced using three tomographic datasets obtained with orthogonally oriented rotation axes. For both samples, the HA in the bone matrix exhibited preferred orientation, with the unit cell c-axis of the HA crystallites tending to be parallel with the bone surface. In summary, we have demonstrated that XRD-CT combined with an intuitive reconstruction procedure is becoming a powerful tool for studying palaeontological samples.
On the Move to Meaningful Internet Systems: OTM 2011 Part II (2011)

The two-volume set LNCS 7044 and 7045 constitutes the refereed proceedings of three confederated international conferences: Cooperative Information Systems (CoopIS 2011), Distributed Objects and Applications - Secure Virtual Infrastructures (DOA-SVI 2011), and Ontologies, DataBases and Applications of SEmantics (ODBASE 2011) held as part of OTM 2011 in October 2011 in Hersonissos on the island of Crete, Greece. The 55 revised full papers presented were carefully reviewed and selected from a total of 141 submissions. The 28 papers included in the second volume constitute the proceedings of DOA-SVI 2011 with 15 full papers organized in topical sections on performance measurement and optimization, instrumentation, monitoring, and provisioning, quality of service, security and privacy, and models and methods, and ODBASE 2011 with 9 full papers organized in topical sections on acquisition of semantic information, use of semantic information, and reuse of semantic information and 4 short papers.
Wound Healing and Cell Therapy for Muscle Repair (2013)

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Sea Spotter: A fully staring Naval IRST System (2013)

Infrared sensor technology, high performance computing hardware and advanced detection and tracking algorithms have enabled a new generation of infrared warning systems for navy surface vessels. In this paper we describe Sea Spotter - a new third-generation naval IRST system, which is unique in offering a fully staring electro-optical imaging unit. Starting from naval IRST operational requirements, we describe the considerations and constraints that led us to the configuration of the sensor head and the supporting hardware. The second part of the paper is dedicated to the target acquisition methodology, including the use of originally developed machine learning technology for target acquisition and tracking.
Administration (of a Substance) (2016)

This Glossary of Terms Related to Pharmaceutics is needed by practitioners in the field of pharmaceutics as this field fulfills an important and crucial role, different from the roles of other scientific disciplines involved in the drugmaking process. The glossary contains 168 definitions used in pharmaceutics. These are related to various aspects of this discipline, such as: (1) physicochemical characterization of pharmaceutical preparations and the active ingredients they contain; (2) unit operations used in the practice of pharmaceutics; (3) terms related to the various dosage forms; (4) terms related to the various modes and routes of drug delivery; (5) terms used in pharmacokinetics and biopharmaceutics in general; and additional miscellaneous terms. The field of pharmaceutics itself is of a multidisciplinary nature as its practitioners come from a variety of disciplines, such as chemistry or various biological sciences, thus a glossary containing authoritative definitions would be useful for them. The terms used in pharmaceutics are rarely covered by existing glossaries, and in the cases they are, their definitions are often inappropriate for the field of pharmaceutics and require new or modified definitions to better fit the new context.
Effect of dexamethasone in feed on intestinal permeability, differential white blood cell counts, and immune organs in broiler chicks (2015)

We have previously shown that intestinal barrier function can be adversely affected by poorly digested diets or feed restriction, resulting in increased intestinal inflammation-associated permeability. Three experiments were conducted in broilers to evaluate the effect of dexamethasone (DEX) treatment on systemic fluorescein isothiocyanate-dextran (FITC-D; 3-5 kDa) levels, indicative of increased gut epithelial leakage. Experiment 1 compared DEX injections of 1 mg/kg, once per day on d 3, 5, and 9, with feed administration at 0.57, 1.7, or 5.1 ppm d 4 to 10, with FITC-D serum concentrations 2.5 h after gavage with 4.16 mg/kg FITC-D. All DEX treatments resulted in marked (2 to 6X; P<0.05) increased serum FITC-D levels. Feed DEX administration resulted in greater (P<0.05) gut permeability than injection at any dose, with numerically optimal effects at the lowest dose tested. In experiments 2 and 3, chicks were randomly assigned to a starter ration containing either control (CON) or DEX treated feed (0.57 ppm/kg; d 3 to 10 experiment 2, d 4 to 10 experiment 3). At d 10, all chicks were treated by oral gavage with FITC-D and serum samples were obtained as described above. Samples of the liver were aseptically collected, homogenized, diluted 1:4 wt/vol in sterile saline, and serial dilutions were plated on tryptic soy agar to evaluate total numbers of aerobic bacteria in the liver as an index of bacterial translocation (BT). In both experiments, FITC-D absorption was significantly enhanced (P<0.05) in DEX-treated chicks, again indicating increased paracellular leakage across the gut epithelium associated with dissolution of tight junctions. Experiment 2 differential cell counts showed an increased heterophil/lymphocyte ratio, and immune organ (spleen and bursa of Fabricius) weights for experiments 2 and 3 were decreased (P<0.05) from controls. In experiments 2 and 3, dietary DEX administration resulted in numerically (experiment 2) or significantly (P<0.05) increased enteric BT to the liver, supporting the observation that dietary DEX causes a stress-like inflammatory GI response, which may contribute to subclinical or clinical disease, and may be a useful model for ongoing disease mitigation research related to stress-related diseases of GIT origin.
The router bit extraction technique for removing a well-fixed humeral stem in revision shoulder arthroplasty (2019)

The router bit extraction technique removed a well-fixed humeral component in a very high proportion of patients (98.6%). This method allows surgeons to avoid more invasive approaches involving a cortical window or humeral osteotomy, and their associated complications. Cite this article: <i>Bone Joint J</i> 2019;101-B:1280-1284.
Recognition and Surgical Management of the Upper Airway Resistance Syndrome (1996)

Patients with upper airway resistance syndrome (UARS) have clinical signs and symptoms of excessive daytime somnolence (EDS) in the absence of obstructive sleep apnea. These patients have increased upper airway resistance, reflected by an elevated intrathoracic pressure measurement, despite a normal respiratory disturbance index (RDI). Physical findings often include excessive palatal tissue and narrowing of the oropharynx and hypopharynx. Nine patients with UARS who received surgical treatment were prospectively evaluated. The four men and five women had signs of EDS, with or without snoring. The mean (+/- standard deviation) RDI was 2.1 (+/- 1.2), and the mean esophageal pressure recording during polysomnography was -36.7 (+/- 16.2) cm H2O. The Epworth sleepiness scale was used to quantify EDS. The preoperative score of 12.0 (+/- 6.6) decreased to 3.4 (+/- 1.9) (P = .001) after surgical treatment. A variety of procedures, all including some type of palatal surgery, were performed. No treatment complications occurred. The recognition of UARS and an understanding of the mechanisms responsible for the progressive development of obstructive sleep apnea syndrome may facilitate the prompt identification and treatment of such patients. The pathophysiology of UARS and a preliminary report of its surgical treatment are discussed.
Palladium-Rhodium Catalyst Strategies for LEV Emission Applications (1997)

&lt;div class="htmlview paragraph"&gt;Palladium-rhodium three-way catalysts (Pd/Rh TWCs) demonstrate the most versatile capability in achieving California LEV/ULEV emission standards for various applications ranging from thermally severe high-temperature close-coupled locations to thermally limited cooler underfloor environments. Engine aged dual-brick converters consisting of front Pd catalysts followed by rear Pd/Rh TWCs met ULEV emission standards for a high-temperature close-coupled 4.3L medium-duty truck and LEV standards for a much cooler underfloor 3. IL passenger car location, as well as intermediate environments experienced by a 3.8L vehicle. The Pd + Pd/Rh TWC systems have performance advantages and are more cost effective compared to Pd-only or trimetal (Pt/Pd/Rh) systems. For thermally limited systems such as the 3. IL system, addition of air to the Pd + Pd/Rh system was necessary. Advanced washcoat technologies incorporating stabilized ceria-zirconia promoters demonstrated advantages over earlier generations and alleviate thermal durability concerns of close coupled applications. As a result, passive catalyst only systems can achieve these low emission requirements when sufficient heat is available.&lt;/div&gt;
Output ripple reduction of an automotive multi-phase bi-directional dc-dc converter (2009)

Bi-directional dc-dc converters for automotive applications typically are limited to generate only a small voltage ripple, especially when a ultra-capacitor with a limited ripple current capability is interfaced by the converter. Thus, to minimize the ripple quantities and the converter volume at the same time, interleaved multi-phase dc-dc converters are utilized. However, tolerances of the buck+boost inductors of the interleaved phases generate sub-harmonics in the ripple spectrum that are counterproductive to the advantage of ripple reduction. A method to cancel the fundamental frequency of the voltage ripple is proposed that is applicable to a converter consisting of three or more phases. It is shown that even for a low phase count the overall ripple amplitude is greatly reduced, only by adjustment of the phase shift angles. Experimental results carried out with a three-phase interleaved bi-directional dc-dc converter proof the concept functionality.
Improvement of HfO<inf>2</inf> based RRAM array performances by local Si implantation (2017)

A thorough insight of Si implantation in HfÜ2-based OXRAM is presented, from a material standpoint up to a 4 kbit 1T-1R array. We demonstrate for the first time that local implantation enables switching area localization and significantly decreases forming, set and reset voltages, improves data retention (tails at 3o are stable up to 1000 min at 165°C), while not being detrimental for endurance. In particular using low voltage programming conditions (VF <; 3V with 100 ns pulses), a memory window of 10 at 3σ is demonstrated, paving the way to low power OxRAM arrays with lower variability and improved robustness.