gebhart/patrepeval huggingface dataset:
Subjective face recognition difficulties, aberrant sensibility, sleeping disturbances and aberrant eating habits in families with Asperger syndrome (2005)

An aberrant processing of sensory information appears to be a common feature in AS. The impact of these and other clinical features that are not incorporated in the ICD-10 and DSM-IV on our understanding of AS may hitherto have been underestimated. These associated clinical traits may well be reflected by the behavioural characteristics of these individuals.
Super Learner In Prediction (2010)

Super learning is a general loss based learning method that has been proposed and analyzed theoretically in van der Laan et al. (2007). In this article we consider super learning for prediction. The super learner is a prediction method designed to find the optimal combination of a collection of prediction algorithms. The super learner algorithm finds the combination of algorithms minimizing the cross-validated risk. The super learner framework is built on the theory of cross-validation and allows for a general class of prediction algorithms to be considered for the ensemble. Due to the previously established oracle results for the cross-validation selector, the super learner has been proven to represent an asymptotically optimal system for learning. In this article we demonstrate the practical implementation and finite sample performance of super learning in prediction.
Effects of Argon as the primary impurity in anthropogenic carbon dioxide mixtures on the decompression wave speed (2016)

In order to determine the material fracture resistance necessary to provide adequate control of the propagation of ductile fracture in a pipeline, a knowledge of the decompression wave speed ( W ) following the quasi‐instantaneous formation of an unstable, full‐bore rupture is necessary. The thermodynamic and fluid dynamics background of such calculations is understood, but predictions based on specific equations of state need to be validated against experimental measurements. A program of tests has been conducted using a specially constructed shock tube to determine the impact of impurities on W in carbon dioxide (CO 2 ), so that the results can be compared to two existing theoretical models. In this paper, data and analysis results are presented for four tests involving simulated anthropogenic CO 2 mixtures containing Argon (Ar) as the primary impurity. These mixtures represent typical oxy‐fuel CO 2 capture technology with or without a purification train. Comparisons of the experimentally obtained W with predictions by two commonly used equation of state (EOS) models were also made. Generally, the GERG‐2008 EOS exhibits better overall performance than the Peng‐Robinson (PR) EOS when compared to the experimental results. The bubble point curve as predicted by GERG‐2008 was always at a higher pressure than that predicted by PR for these mixtures. This resulted in the plateau pressure prediction by GERG‐2008 being higher in cases where the isentropes intersect the phase envelope on the bubble point side. An example of pipeline material toughness required to arrest ductile fracture is presented which shows that prediction by GERG‐2008 is more conservative, and is therefore recommended.
Rethinking the Hyperparameters for Fine-tuning (2020)

Fine-tuning from pre-trained ImageNet models has become the de-facto standard for various computer vision tasks. Current practices for fine-tuning typically involve selecting an ad-hoc choice of hyperparameters and keeping them fixed to values normally used for training from scratch. This paper re-examines several common practices of setting hyperparameters for fine-tuning. Our findings are based on extensive empirical evaluation for fine-tuning on various transfer learning benchmarks. (1) While prior works have thoroughly investigated learning rate and batch size, momentum for fine-tuning is a relatively unexplored parameter. We find that the value of momentum also affects fine-tuning performance and connect it with previous theoretical findings. (2) Optimal hyperparameters for fine-tuning, in particular, the effective learning rate, are not only dataset dependent but also sensitive to the similarity between the source domain and target domain. This is in contrast to hyperparameters for training from scratch. (3) Reference-based regularization that keeps models close to the initial model does not necessarily apply for dissimilar datasets. Our findings challenge common practices of fine-tuning and encourages deep learning practitioners to rethink the hyperparameters for fine-tuning.
Structures for dense, crack free thin films (2023)

The process described herein provides a simple and cost effective method for making crack free, high density thin ceramic film. The steps involve depositing a layer of a ceramic material on a porous or dense substrate. The deposited layer is compacted and then the resultant laminate is sintered to achieve a higher density than would have been possible without the pre-firing compaction step.
Supplementary Legends, Table from Fibrotic Response to Neoadjuvant Therapy Predicts Survival in Pancreatic Cancer and Is Measurable with Collagen-Targeted Molecular MRI (2023)

&lt;p&gt;Supplementary Legends, Table&lt;/p&gt;
Supplementary Tables S1-S2 from A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors (2023)

&lt;p&gt;PDF file 89K, This file contains a table listing the top 75 genes correlated with RAF-inhibitor sensitivity in BRAFV600E-mutant cell lines as well as a table describing the IHC results summarized in Main Figure 2b and 2c&lt;/p&gt;
Isn't it time to abandon cine film? (1990)

Cine has served our needs well since the early 1950s. For the first time, it allowed recording of motion studies of the cardiac structures on film. The cine technique has been standardized over the years, both the camera and the display. Cine filming techniques, however, have not advanced, except for new film products with faster emulsions and better-quality films. Video electronic imaging has made rapid advancements. These were prompted by the broadcast industry when the requirements for color were developed in the 1960s and by the advent of new recording techniques that provided a very stable video time base from analog tape recorders. The medical field has been able to capitalize on these developments and to produce some of our own that have not been applied in the broadcast world. These include pulsed progressive 525-line video acquisition of cardiac images in the cardiac catheterization laboratory. We also have been able to capitalize on the improved detector technology that the broadcast world has developed, such as the plumbicon pickup tubes, which produce images with very little lag and so provide images with improved resolution. These developments also have enabled us to reduce radiation to both the patient and the laboratory personnel, especially with implementation of the pulsed progressive acquisition, with which the dose has been reduced 50%. With the advent of interventional procedures in the cardiac catheterization laboratory, the need to assess images immediately cannot be fulfilled by cine filming because of the requirement for the processing of the film with its inherent delays. Quantification of cardiac structures is required to assess the outcome of interventional techniques.(ABSTRACT TRUNCATED AT 250 WORDS)
Inhalation of tobramycin using simulated cystic fibrosis patient profiles (2016)

Our findings indicate that the T-326 Inhaler provides reliable drug delivery at flow rates likely to be achieved by a broad spectrum of patients with CF. Importantly, forceful inhalation was not required to achieve a robust TLD<sub>in vitro</sub> . Pediatr Pulmonol. 2016;51:1159-1167. © 2016 Wiley Periodicals, Inc.
Characterization of bis(2,4,6-tri-tert-butylphenyl)germanium(II) using extended x-ray absorption fine structure (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of bis(2,4,6-tri-tert-butylphenyl)germanium(II) using extended x-ray absorption fine structureKunio. Mochida, Akira. Fujii, Noriko. Tsuchiya, Kazuyuki. Tohji, and Yasuo. UdagawaCite this: Organometallics 1987, 6, 8, 1811–1812Publication Date (Print):August 1, 1987Publication History Published online1 May 2002Published inissue 1 August 1987https://doi.org/10.1021/om00151a033RIGHTS & PERMISSIONSArticle Views70Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (289 KB) Get e-Alerts Get e-Alerts
RADAR Phase Conjugation: Applications and Prospects (2006)

In this article, phase conjugation in radar is studied. A method developed by ONERA (M. Lesturgie, 2001) is used and then the performances of the process are evaluated. Comparisons between phase conjugation and classical radar processes are established
Supplementary Data from Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer (2023)

Supplementary Data from Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer
ChemInform Abstract: Regioselectivity in the Alkaline Thiolate Deprotection of Aryl Methyl Ethers. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ITAC: A complete 3D integration test platform (2016)

System integration takes benefit from 3D stacking technology in a wide range of applications such as smart imagers, photonic, wide I/O memories and high-performance computing. The 700 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ITAC 3D integration test platform contains a set of “Integrated Technological and Application Circuits” for process development, electrical and RF characterization, reliability, die stacking, warpage and underfilling studies, DC-DC converter and IntAct chip which is the full application chip. After a brief presentation of the targeted high performance computing application. The contributions integrated in the test platform are described with a particular focus on the 10 μm diameter 20 μm pitch die-to-die interconnects which is the key technology of the 3D stack. These test vehicles have been embedded on the same silicon to secure the application chip at all the steps from technology development to assembly and test.
DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes (2012)

While DNA methyltransferase1 (DNMT1) is classically known for its functions as a maintenance methyltransferase enzyme, additional roles for DNMT1 in gene expression are not as clearly understood. Several groups have shown that deletion of the catalytic domain from DNMT1 does not abolish repressive activity of the protein against a reporter gene. In our studies, we examine the repressor function of catalytically inactive DNMT1 at endogenous genes. First, potential DNMT1 target genes were identified by searching for genes up-regulated in HCT116 colon cancer cells genetically disrupted for DNMT1 (DNMT1(-/-) hypomorph cells). Next, the requirement for DNMT1 activity for repression of these genes was assessed by stably restoring expression of wild-type or catalytically inactive DNMT1. Both wild-type and mutant proteins are able to occupy the promoters and repress the expression of a set of target genes, and induce, at these promoters, both the depletion of active histone marks and the recruitment of a H3K4 demethylase, KDM1A/LSD1. Together, our findings show that there are genes for which DNMT1 acts as a transcriptional repressor independent from its methyltransferase function and that this repressive function may invoke a role for a scaffolding function of the protein at target genes.
La redistribución del proceso de acumulación de capital en el Ecuador entre los años 2006 al 2016 (2019)

The study analyzes the importance of the role of the State in the economy and in the process of accumulation of wealth. The economic model implemented by the Government of Rafael Correa, managed to displace private enterprise, thereby generating an increase in dependence on the economy by the State; the organic composition of capital was redistributed, limiting the expanded reproduction of capital (by the interference of the state in the process of accumulation of wealth), thus counteracting the dynamics of the economy on the part of the capitalist enterprise. The gravitante of this situation is that in spite of the enormous economic resources, the external debt has grown, the problem of employment has not been solved and the only tool used to level the government's finances, has been a policy administration prosecutors aggressively and persecuting.
Autodirective microphone systems for natural communication with speech recognizers (1991)

Two technological advances support new sophistication in sound capture; namely, high-quality low-cost electret microphones and high-speed economical signal processors. Combined with new understanding in acoustic beamforming, these technologies permit spatially-selective transduction of speech signals several octaves in bandwidth. Spatial selectivity mitigates the effects of noise and reverberation, and digital processing provides the capability for speech-seeking, autodirective performance. This report outlines the principles of autodirective beamforming for acoustic arrays, and it describes two experimental implementations. It also summarizes the direction and emphasis of continuing research.
Abstract 5090: The role of p32 in brain metastasis (2010)

Abstract Brain metastases are among the most feared complication in cancer. To develop effective and targeted therapies for treatment of brain metastases, we need a better understanding of the mechanisms that control cancer cell growth within the brain microenvironment. We previously found evidence that brain metastatic cells have increased rates of oxidative phosphorylation and redox potential compared to tumor cells from extracranial lesions. Here we sought to identify mechanisms involved, and to identify potential targets for the inhibition of metastatic growth in the brain. Many of the genes involved in transformation such as Myc, AKT, and p53 have extensive effects on the metabolism, suggesting that tumors might be susceptible to antimetabolic drugs. One of the proteins that has been shown to be upregulated in many solid tumors is the protein p32. P32 is a multi-compartmental and multi-functional protein which has a regulatory function in oxidative phosphorylation, in addition to being involved in the regulation of apoptosis and autophagy. We found p32 expressed in human cancer cells capable of seeding brain metastases in immune deficient mice, and we hypothesized that p32 contributes to cell survival and proliferation within the brain microenvironment. We knocked down p32 in brain homing variants of the MDA-MB-231 and MDA-MB-435 metastasis cell models. Following luciferase tagged tumor cells by non-invasive bioluminescence imaging revealed that stable p32 knockdown greatly reduced metastatic activity in both MDA-MB-231 brain specific variant and the MDA-MB 435 cell line. Furthermore, our genomic profiling of p32 knock-down and control cells identified candidate genes in the respiration chain involved in p32-dependent tumor cell survival and growth that may impact progression to brain metastasis. Thus, the expression and functionality of p32 in tumor cells capable of colonizing the brain appears associated with changes in crucial pathways that enable the tumor cells to proliferate and survive within the brain microenvironment. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5090.
A prognostic profile of hypoxia-induced genes for localised high-grade soft tissue sarcoma (2016)

The hypoxia-induced gene profile is a validated independent prognostic marker that may help identify STS patients needing more aggressive or different adjuvant treatment.
Small geometry depleted base bipolar transistors (BSIT)&#8212;VLSI devices? (1981)

An essential characteristic of devices which are viable candidates for VLSI circuits is that they must have electrical characteristics which can tolerate process variations. Conventional bipolar junction transistors (BJT) are well known to be limited by punchthrough when vertical basewidths axe decreased; these devices are, however, relatively tolerant of linewidth variations. The depleted base bipolar transistor represents a limiting case when the metallurgical basewidth is allowed to shrink to zero. Such devices, also called bipolar static induction transistors (BSIT), have been proposed as candidates for VLSI logic circuits. This paper describes the basic device physics of depleted base transistors and presents experimental verification of the theoretical modeling. The two essential conclusions that are drawn are that such devices can only achieve performance (in terms of transconductance) comparable to BJT's when an electrical p-type base exists (n-p-n device) and secondly, that BSIT's have characteristics which are extremely sensitive to process variations (linewidths, junction depths, and doping profiles). As a consequence, we conclude that while pure bipolar transistors may play an important role in VLSI circuits, depleted base structures such as the BSlT, are unlikely candidates for such applications.
In Vivo Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound (2012)

There is an urgent need for new antibacterials that pinpoint novel targets and thereby avoid existing resistance mechanisms. We have created novel synthetic antibacterials through structure-based drug design that specifically target bacterial thymidylate kinase (TMK), a nucleotide kinase essential in the DNA synthesis pathway. A high-resolution structure shows compound TK-666 binding partly in the thymidine monophosphate substrate site, but also forming new induced-fit interactions that give picomolar affinity. TK-666 has potent, broad-spectrum Gram-positive microbiological activity (including activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus), bactericidal action with rapid killing kinetics, excellent target selectivity over the human ortholog, and low resistance rates. We demonstrate in vivo efficacy against S. aureus in a murine infected-thigh model. This work presents the first validation of TMK as a compelling antibacterial target and provides a rationale for pursuing novel clinical candidates for treating Gram-positive infections through TMK.
The complete nucleotide sequence of the human gonadotropin-releasing hormone gene (1989)

Journal Article The complete nucleotide sequence of the human gonadotropin-releasing hormone gene Get access J.S. Hayflick, J.S. Hayflick Department of Developmental Biology, Genentech, Inc.460 Point San Bruno Boulevard, South San Francisco, CA 94080, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar J.P. Adelman, J.P. Adelman Department of Developmental Biology, Genentech, Inc.460 Point San Bruno Boulevard, South San Francisco, CA 94080, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar P.H. Seeburg P.H. Seeburg Department of Developmental Biology, Genentech, Inc.460 Point San Bruno Boulevard, South San Francisco, CA 94080, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 17, Issue 15, 11 August 1989, Pages 6403–6404, https://doi.org/10.1093/nar/17.15.6403 Published: 11 August 1989 Article history Received: 20 June 1989 Published: 11 August 1989
Somatic ERCC2 Mutations Correlate with Cisplatin Sensitivity in Muscle-Invasive Urothelial Carcinoma (2014)

Somatic ERCC2 mutations correlate with complete response to cisplatin-based chemosensitivity in muscle-invasive urothelial carcinoma, and clinically identified mutations lead to cisplatin sensitivity in vitro. Nucleotide excision repair pathway defects may drive exceptional response to conventional chemotherapy.
Familial migraine with and without aura: clinical characteristics and co‐occurrence (2001)

Migraine with aura (MwA) and migraine without aura (MwoA) are the two common forms of migraine. Many migraine patients suffer from both kinds of attacks. In a questionnaire-based study using the current International Headache Society (IHS) criteria we determined the clinical characteristics and occurrence of MwA + MwoA in 1000 migraine patients belonging to 210 Finnish migraine families. Nine hundred and six patients were able to indicate whether they suffered from MwA (but not MwoA), migraine aura without headache (migraine equivalent) (but not MwA) or MwA and MwoA. Of these patients, 3.2% had experienced MwoA, 11.1% MwA, 40.6% MwA + MwoA, 23.5% MwoA and 20.3% MwA-like symptoms not meeting the IHS criteria. The high prevalence of MwA attacks in the families studied supports the belief that aura has a strong hereditary component. The MwA + MwoA patients had significantly more severe attacks, more typical headache and more prodromal symptoms than the MwA and MwoA subjects. Therefore, it is possible that there is a continuum with pure MwA at the neural and pure MwoA at the headache end of the spectrum, and MwA + MwoA lying in between the two. The MwA + MwoA patients would thus be liable to both types of migraine, making their attacks more characteristic and more severe. This would also explain why the co-occurrence of MwA and MwoA is more common in the clinic compared with population based epidemiological studies. These findings have consequences for future research on liability genes for migraine.
Data-Driven Local Control Design for Active Distribution Grids Using Off-Line Optimal Power Flow and Machine Learning Techniques (2019)

The optimal control of distribution networks often requires monitoring and communication infrastructure, either centralized or distributed. However, most of the current distribution systems lack this kind of infrastructure and rely on sub-optimal, fit-and-forget, local controls to ensure the security of the network. In this paper, we propose a data-driven algorithm that uses historical data, advanced optimization techniques, and machine learning methods to design local controls that emulate the optimal behavior without the use of any communication. We demonstrate the performance of the optimized local control on a three-phase, unbalanced, low-voltage, distribution network. The results show that our data-driven methodology clearly outperforms standard industry local control and successfully imitates an optimal-power-flow-based control.