gebhart/patrepeval huggingface dataset:
Generation of charge current from magnetization oscillation via the inverse of voltage-controlled magnetic anisotropy effect (2020)

It is well known that oscillating magnetization induces charge current in a circuit via Faraday's law of electromagnetic induction. New physical phenomena by which magnetization dynamics can produce charge current have gained considerable interest recently. For example, moving magnetization textures, such as domain walls, generates charge current through the spin-motive force. Here, we examine an entirely different effect, which couples magnetization and electric field at the interface between an ultrathin metallic ferromagnet and dielectric. We show that this coupling can convert magnetic energy into electrical energy. This phenomenon is the Onsager reciprocal of the voltage-controlled magnetic anisotropy effect. The effect provides a previously unexplored probe to measure the magnetization dynamics of nanomagnets.
Evaluating the quality of red blood cell concentrates irradiated before or after cryopreservation (2019)

Irradiation of RCCs can be performed pre- or postcryopreservation with little effect on the RCC product, as both irradiated groups resulted in RCCs that were comparable to the nonirradiated cryopreserved RCCs.
Experiences Porting the Jikes RVM to Linux/IA32 (2002)

porting the Jikes Research Virtual Machine from its first platform, AIX/PowerPC, to its second, Linux/IA32. We discuss the main is- sues in realizing both an initial functional port, and then tuning efforts to achieve competitive performance. The paper presents software engineering issues in building a portable runtime system and compilers, as well as specific optimizations to improve performance on IA32.
Cerebrovascular accidents in Ebstein’s anomaly (2019)

Patients with EA are at substantive risk for CVA. Histories of migraines/headaches and interatrial shunts should prompt concern for paradoxical embolic CVAs. This has significant implications for all patients with atrial-level shunting.
Door Detection Algorithm of Mobile Robot in Hallway Using PC-Camera (2004)

Door Detection Algorithm of Mobile Robot in Hallway Using PC-Camera Jung-Suk Lee, Nakju Lett Doh, Wan Kyun Chung, Bum-Jae You, Young Il Youm Abstract: In this paper, an algorithm for door detection using a cheap PC-camera is developed based on the Bayesian network in a hallway where doors are located at various depth. The open/close status of the door is also important in developing a GVG-SLAM and we extracted five important door features from the image and distance data. We applied the Bayesian network algorithm and an entropy concept to increase the robustness. Experiment result shows that the proposed algorithm can help the GVG-SLAM of mobile robot by successfully identifying the status of the door. Keywords: GVG- SLAM, door detection, low-cost sensor system, Bayesian-network DOI: https://doi.org/10.22260/ISARC2004/0079 Download fulltext Download BibTex Download Endnote (RIS) TeX Import to Mendeley
Delay Analysis for Wireless Local Area Networks with Multipacket Reception under Finite Load (2008)

To date, most analysis of WLANs has been focused on their operation under saturation condition. This work is an attempt to understand the fundamental performance of WLANs under unsaturated condition. In particular, we are interested in the delay performance when collisions of packets are resolved by an exponential backoff mechanism. Using a multiple-vacation queueing model, we derive an explicit expression for packet delay distribution. It is found that under some circumstances, mean delay and delay jitter may approach infinity even when the traffic load is way below the saturation throughput. Saturation throughput is therefore not a sound measure of WLAN capacity when the underlying applications are delay sensitive. To bridge the gap, we define safe-bounded-mean-delay (SBMD) throughput and safe-bounded-delay-jitter (SBDJ) throughput that reflect the actual network capacity users can enjoy when they require bounded mean delay and delay jitter, respectively. The analytical model in this paper is general enough to cover both single-packet reception (SPR) and multi-packet reception (MPR) WLANs, as well as carrier-sensing and non-carrier- sensing networks. We show that the SBMD and SBDJ throughputs scale super-linearly with the MPR capability of a network. Together with our earlier work that proves super-linear throughput scaling under saturation condition, our results here complete the demonstration of MPR as a powerful capacity-enhancement technique for both delay-sensitive and delay-tolerant applications.
Novel multiparameter correlates of Coxiella burnetii infection and vaccination identified by longitudinal deep immune profiling (2020)

Q-fever is a flu-like illness caused by Coxiella burnetii (Cb), a highly infectious intracellular bacterium. There is an unmet need for a safe and effective vaccine for Q-fever. Correlates of immune protection to Cb infection are limited. We proposed that analysis by longitudinal high dimensional immune (HDI) profiling using mass cytometry combined with other measures of vaccination and protection could be used to identify novel correlates of effective vaccination and control of Cb infection. Using a vaccine-challenge model in HLA-DR transgenic mice, we demonstrated significant alterations in circulating T-cell and innate immune populations that distinguished vaccinated from naïve mice within 10 days, and persisted until at least 35 days post-vaccination. Following challenge, vaccinated mice exhibited reduced bacterial burden and splenomegaly, along with distinct effector T-cell and monocyte profiles. Correlation of HDI data to serological and pathological measurements was performed. Our data indicate a Th1-biased response to Cb, consistent with previous reports, and identify Ly6C, CD73, and T-bet expression in T-cell, NK-cell, and monocytic populations as distinguishing features between vaccinated and naïve mice. This study refines the understanding of the integrated immune response to Cb vaccine and challenge, which can inform the assessment of candidate vaccines for Cb.
Supplementary Movie S1 from Real-time, Near-Infrared Fluorescence Imaging with an Optimized Dye/Light Source/Camera Combination for Surgical Guidance of Prostate Cancer (2023)

&lt;p&gt;Supplementary Movie S1. To model human laparoscopic tumor resection, athymic Nu/Nu mice harboring PSMA-positive xenografts were administered 19.1 μg/kg (HED of 100 μg for a 70 Kg male) YC-27 via tail vein injection. The mice were placed in a laparoscopic training box, and the PSMA-positive xenografts were resected 10 hours after injection of YC-27 with the guidance of the LumiNIR{trade mark, serif} system. Imaging was done using a 830nm laser to visualize the whole animal and 780nm laser to identify the PSMA-positive xenograft.&lt;/p&gt;
Identification of geometrical isomers using vibrational circular dichroism spectroscopy: a series of mixed-ligand complexes of diamagnetic Co(iii) ions (2010)

Vibrational circular dichroism (VCD) spectra were measured on the chloroform solutions of a series of mixed-ligand diamagnetic Co(III) complexes, [Co(tfac)(n)(acac)(3-n)] (n = 0-3, tfac = 1,1,1-trifluoro-2,4-pentanedionato; acac = acetylacetonato). Distinct differences were observed in the VCD spectra among the geometrical isomers of the same ligand composition. Such differentiation was hardly possible by their infra-red spectra alone. The structural identification of these isomers was performed in conjunction with DFT calculations.
Lumbar spine: postoperative MR imaging with Gd-DTPA. (1988)

Thirty patients with failed back surgery syndrome were studied to evaluate the effectiveness of magnetic resonance (MR) imaging with gadolinium-diethylenetriaminepentaacetic acid/dimeglumine (Gd-DTPA) in differentiating postoperative epidural fibrosis (scar) from recurrent disk herniation. Pre- and postcontrast MR images were interpreted without access to other diagnostic, surgical, or pathologic findings. Seventeen patients had surgical and pathologic correlation of the MR findings at 19 disk levels. The precontrast studies had a sensitivity, specificity, and accuracy of 100%, 71%, and 89%, respectively. The enhanced MR studies correctly depicted the character of abnormal epidural soft tissue in 17 patients at all 19 levels. Scar showed heterogeneous enhancement on the early T1-weighted spin-echo images obtained within 10 minutes after contrast material administration. Herniated disk did not show significant enhancement on the early studies but showed variable degrees of enhancement on delayed images in nine of 12 cases. Other criteria were found to be less useful than the pattern of enhancement. Results indicate that precontrast and early postcontrast T1-weighted spin-echo studies are highly accurate in separating epidural fibrosis from herniated disk.
Expectation Maximization driven Geodesic Active Contour with Overlap Resolution (EMaGACOR): Application to Lymphocyte Segmentation on Breast Cancer Histopathology (2009)

The presence of lymphocytic infiltration (LI) has been correlated with nodal metastasis and tumor recurrence in HER2+breast cancer (BC), making it important to study LI. The ability to detect and quantify extent of LI could serve as an image based prognostic tool for HER2+ BC patients. Lymphocyte segmentation in H & E-stained BC histopathology images is, however, complicated due to the similarity in appearance between lymphocyte nuclei and cancer nuclei. Additional challenges include biological variability, histological artifacts, and high prevalence of overlapping objects. Although active contours are widely employed in segmentation, they are limited in their ability to segment overlapping objects. In this paper, we propose a segmentation scheme (EMaGACOR) that integrates Expectation Maximization (EM) based segmentation with a geodesic active contour (GAC). Additionally, a novel heuristic edge-path algorithm exploits the size of lymphocytes to split contours that enclose overlapping objects. For a total of 62 HER2+ breast biopsy images, EMaGACOR was found to have a detection sensitivity of over 90% and a positive predictive value of over 78%. By comparison, EMaGAC (model without overlap resolution) and GAC (Randomly initialized geodesic active contour) model yielded corresponding sensitivities of 57.4% and 26.7%, respectively. Furthermore, EMaGACOR was able to resolve over 92% of overlaps. Our scheme was found to be robust, reproducible, accurate, and could potentially be applied to other biomedical image segmentation applications.
Identification of metastasis-related genes in a mouse model using a library of randomized ribozymes. VOLUME 279 (2004) PAGES 38083-38086 (2006)

PAGE 38085: In Fig. 4B, due to an inadvertent error, the wrong images were included. The correct Fig. 4B is shown below. The figure legend and text remain unchanged.
Glycosylation Benchmark Profile for HIV-1 Envelope Glycoprotein Production Based on Eleven Env Trimers (2017)

HIV-1 envelope glycoprotein (Env) glycosylation is important because individual glycans are components of multiple broadly neutralizing antibody epitopes, while shielding other sites that might otherwise be immunogenic. The glycosylation on Env is influenced by a variety of factors, including the genotype of the protein, the cell line used for its expression, and the details of the construct design. Here, we used a mass spectrometry (MS)-based approach to map the complete glycosylation profile at every site in multiple HIV-1 Env trimers, accomplishing two goals. (i) We determined which glycosylation sites contain conserved glycan profiles across many trimeric Envs. (ii) We identified the variables that impact Env's glycosylation profile at sites with divergent glycosylation. Over half of the gp120 glycosylation sites on 11 different trimeric Envs have a conserved glycan profile, indicating that a native consensus glycosylation profile does indeed exist among trimers. We showed that some soluble gp120s and gp140s exhibit highly divergent glycosylation profiles compared to trimeric Env. We also assessed the impact of several variables on Env glycosylation: truncating the full-length Env; producing Env, instead of the more virologically relevant T lymphocytes, in CHO cells; and purifying Env with different chromatographic platforms, including nickel-nitrilotriacetic acid (Ni-NTA), 2G12, and PGT151 affinity. This report provides the first consensus glycosylation profile of Env trimers, which should serve as a useful benchmark for HIV-1 vaccine developers. This report also defines the sites where glycosylation may be impacted when Env trimers are truncated or produced in CHO cells.<b>IMPORTANCE</b> A protective HIV-1 vaccine will likely include a recombinant version of the viral envelope glycoprotein (Env). Env is highly glycosylated, and yet vaccine developers have lacked guidance on how to assess whether their immunogens have optimal glycosylation. The following important questions are still unanswered. (i) What is the "target" glycosylation profile, when the goal is to generate a natively glycosylated protein? (ii) What variables exert the greatest influence on Env glycosylation? We identified numerous sites on Env where the glycosylation profile does not deviate in 11 different Env trimers, and we investigated the impact on the divergent glycosylation profiles of changing the genotype of the Env sequence, the construct design, the purification method, and the producer cell type. The data presented here give vaccine developers a "glycosylation target" for their immunogens, and they show how protein production variables can impact Env glycosylation.
Treat registry results: correlations between physician assessments of disease severity and IBDQ in crohn's disease patients (2000)

Treat registry results: correlations between physician assessments of disease severity and IBDQ in crohn's disease patients
‘Race’, Employment, and Contract Compliance: A Way Forward for Local Authorities? (2004)

The concern of this article is with action at the local level to combat racial inequality in employment. It draws on the authors' evaluation of the ‘West Midlands Common Standard’, an innovative policy introduced by a consortium of West Midlands councils to ensure their contractors have, and implement, an equal opportunities in employment policy. The article assesses the impact of the initiative and its potential transferability. It is argued that the Common Standard provides a highly promising model for other local authorities to adopt.
Modulation of secretin release by neuropeptides in secretin-producing cells (1998)

Nerve fibers containing bombesin (BB)/gastrin-releasing polypeptide (GRP), pituitary adenylate cyclase-activating polypeptide (PACAP), vasoactive intestinal polypeptide (VIP), or galanin are known to innervate the mucosa of the upper small intestine. Both BB/GRP and PACAP have been shown to elicit secretin secretion in vivo. We studied whether the above-mentioned neuropeptides can act directly on secretin-producing cells, including the murine neuroendocrine cell line STC-1 and a secretin cell-enriched preparation isolated from rat upper small intestinal mucosa. Secretin release from both cell types was stimulated by various agents known to elicit secretin release and by the neuropeptides BB, GRP, and PACAP, suggesting a comparable response between the two cell preparations. The effects of neuropeptides were further studied in STC-1 cells. BB, GRP, and PACAP stimulated secretin release time and concentration dependently. VIP also stimulated secretin release concentration dependently. Stimulation by BB/GRP or PACAP was accompanied by elevation of inositol-1,4,5-trisphosphate (IP3) or cAMP, respectively. The stimulatory effect of PACAP on secretin release was synergistically enhanced by BB without any synergistic increase in IP3 or cAMP production, suggesting cross talk between different signal transduction pathways downstream of the production of these two second messengers. The L-type Ca2+ channel blocker diltiazem (10 microM) and the Ca2+ chelator EGTA (1 mM) significantly inhibited BB-stimulated secretin release by 64% and 59%, respectively, and inhibited PACAP-stimulated release by 75% and 55%, respectively. The protein kinase A-specific inhibitor Rp-cAMPS (100 microM) also inhibited both BB- and PACAP-stimulated secretin release by 30% and 62%, respectively. Galanin inhibited BB- and PACAP-stimulated secretin release and production of second messengers in a concentration-dependent and pertussis toxin-sensitive manner. These results suggested that the neuropeptides BB/GRP, PACAP, VIP, and galanin can modulate secretin release in secretin-producing cells and that STC-1 cells can serve as a useful model for studying the cellular mechanism of secretin secretion elicited by luminal secretagogues and neuropeptides.
Signal processing for multiGigabit communication (2009)

The sophisticated digital signal processing (DSP) at the core of modern communication receivers implicitly assumes the availability of accurate analog-to-digital converters (ADCs). As communication speeds scale up, however, high-rate, high-precision ADCs are either not available, or are too costly or power-hungry. In this paper, we survey our recent results on DSP-centric receiver design with sloppy ADCs. For applications requiring limited dynamic range (e.g., small constellations over line-of-sight channels), we consider the performance achievable with ADCs whose precision is drastically smaller (e.g., 1-4 bits) than those in current practice (e.g. 8-12 bits), with a view to characterizing information-theoretic limits as well as developing practical receiver algorithms. For applications requiring larger dynamic range (e.g., large constellations and/or dispersive channels), we consider receiver architectures centered around time-interleaved ADCs, addressing the mismatch between the parallel ADCs for the specific context of their use within a communication receiver, with a view to preventing error floors in receiver performance.
Adjudication of GI Events from Long-Term Placebo-Controlled Trials Provides Evidence for GI Safety and Tolerability of Celecoxib vs Placebo (2007)

Purpose: To analyze incidence of clinically significant upper or lower gastrointestinal adverse events (CSULGIEs) of celecoxib vs placebo, using adjudicated gastrointestinal (GI) data from the Adenoma Prevention with Celecoxib (APC), and Prevention of Colorectal Sporadic Adenomatous Polyps (PreSAP) studies. Methods: In APC, 2035 subjects were randomized to celecoxib 200 mg BID, 400 mg BID, or placebo for 3 years. In PreSAP, 1561 subjects were randomized to 400 mg QD or placebo for 3 years. Adverse events (AEs), bleeds, perforations, obstructions or ulcers were evaluated up to 30 days last dose by a blinded GI Endpoint Adjudication Committee (GIEAC). Subjects with GI AEs, GI-related deaths, or Hb fall 3 g from baseline were included. Time between first dose and CSULGIE was analyzed by a Cox proportional hazards model, stratified by study, with aspirin as covariate. Age, gender, clinical history were also analyzed. Results: Of total population reporting AEs (N = 3588), 97 subjects met inclusion criteria and were reviewed by the GIEAC. 54 were adjudicated as having CSULGIEs (1.62% for celecoxib; 1.30% for placebo). Incidence of CSULGIEs was higher among aspirin-users in both groups (2.99% vs 1.17% celecoxib; 2.83% vs 0.81% placebo). No significant difference was shown in hazard ratio (HR) or relative risk (RR) of celecoxib vs placebo. HR of celecoxib vs placebo was 1.24 with upper 0.025 CI at 2.21 (rejects non-inferiority). There were no significant differences in RR of CSULGIEs between treatments in either aspirin (RR 1.06, 95% CI 0.48, 2.34, P= 0.894) or non-aspirin users (RR 1.44, 95% CI 0.64, 3.25, P= 0.374). Aspirin and age were significant contributors of toxicity. Conclusion: In this pooled analysis, testing for non-inferiority, incidence of CSULGIEs was equivalent for celecoxib and placebo. Importantly, there were few events and the analysis was underpowered. These findings support celcoxib's long-term GI safety and tolerability, and show long-term aspirin use is associated with significant GI toxicity.Table
Advances in Perforating Technology Continue (2010)

Technology Update Perforations represent the critical link between the wellbore and reservoir in cased wells and, thus, have a significant impact on well productivity and ultimate recovery. Important advances have been made in the past several years in the technology of perforation through the incorporation of reactive materials into oilfield shaped charges and through the advancement of stressed-rock testing of charge systems, as opposed to testing performed in cement. A new and potentially powerful extension to stressed-rock testing is the use of 3D digital-imaging technology and advanced analytical methods. The advances being achieved in perforating appear likely to play a vital role in meeting the challenges of maximizing the productivity and recovery of wells drilled in the hard, low-permeability rock increasingly being targeted by the drill bit today. And although not yet exploited commercially, the capability already exists to design charges for application in specific lithologies, possibly even individual formations. Testing Under More Realistic Conditions In practical terms, penetration into cement under surface conditions is an unreliable indicator of the performance that can be expected when charges are shot under real, downhole conditions. Stressed rock does not behave like un confined cement. More specifically, the new reservoirs of the 21st century—such as hard, subsalt carbonates or shales with nanodarcy permeability—are fundamentally different, and several orders of magnitude more difficult to understand than the sandstones on which predictive correlations from cement penetration to rock penetration were based (Behrmann et al. 2009). New science and products have been needed to complete wells effectively in these environments. The first step toward developing solutions for such environments was the construction of perforator-evaluation facilities in which shaped-charge systems could be tested under conditions more closely representing the wellbore and reservoir (API RP 19B 2006). In this type of facility, frequently referred to as a flow lab, natural-rock targets are subjected to realistic levels of effective stress, while wellbore and pore pressures are accurately simulated to create appropriate static and dynamic pressure effects. If these tests are designed and executed successfully, they can provide a whole new level of insight into how effectively a particular perforating system will connect a wellbore to its target formation. It is fair to say that only the handful of companies that have invested in such flow-lab facilities are uncovering perforating solutions suitable for the increasingly complex reservoirs that will be the industry’s focus in the years ahead.