gebhart/patrepeval huggingface dataset:
A Primer to Method Engineering (1996)

Traditional methodologies for information system (I.S.) development are—by nature—general purpose. As such, they contain an ideal set of methods, techniques, and guidelines that in reality can never be followed literally. They must be tuned to the situation at hand. Steps are sometimes omitted, added, or modified. Guidelines are often modified or ignored to fit special circumstances, such as technology, development expertise, the application, and external factors. [Harmsen, 1994]
A $4 \times 4 \times 2$ Homogeneous Scalable 3D Network-on-Chip Circuit With 326 MFlit/s 0.66 pJ/b Robust and Fault Tolerant Asynchronous 3D Links (2016)

Future many cores, either for high performance computing or for embedded applications, are facing the power wall, and cannot be scaled up using only the reduction of technology nodes; 3D integration, using through silicon via (TSV) as an advanced packaging technology, allows further system integration, while reducing the power dissipation devoted to system-level communication. In this paper, we present a 3D modular and scalable network-on-chip (NoC) architecture implemented using robust asynchronous logic. The 3DNOC circuit targets a Telecom long-term evolution application; it is composed of two die layers, fabricated in 65 nm technology using TSV middle aspect ratio 1:8, and integrates ESD protection, a 3D design-for-test, and a fault tolerant scheme. The 3D links achieve 0.66 pJ/b energy consumption and 326 Mb/s data rate per pin for the parallel link. Thin die effect is demonstrated by thermal analysis and measurements, as well as the dynamic self-adaptation of the 3D link performances with 3D thermal conditions. Finally, the scalability of the 3DNOC circuit, in terms of power delivery network and thermal dissipation, is demonstrated by using simulations up to a 3D stack of eight die layers.
Combination chemotherapy: interaction of 5-methoxymethyldeoxyuridine with adenine arabinoside, 5-ethyldeoxyuridine, 5-iododeoxyuridine, and phosphonoacetic acid against herpes simplex virus types 1 and 2 (1980)

The antiviral activity of 5-methoxymethyl-2'-deoxyuridine (MMUdR) was compared with that of 5-iodo-2'-deoxyuridine (IUdR), 5-ethyl-2'-deoxyuridine (EtUdR), adenine arabinoside (Ara-A), and phosphonoacetic acid (PAA) against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2). MMUdR was more potent than Ara-A and PAA but less active than EtUdR and IUdR against HSV-1 in rabbit kidney (RK-13) cells. In Vero cells, the antiviral activities of MMUdR, Ara-A, and PAA against HSV-1 were of the same order of magnitude. The antiviral potency against HSV-2 varied with the strain of virus used. All strains of HSV-2 were markedly inhibited by EtUdR and IUdR and to a lesser degree by PAA. However, considerable variation was noticed in the susceptibility of HSV-2 strains to Ara-A and MMUdR. Interaction of MMUdR with Ara-A, EtUdR, IUdR, and PAA was investigated by the method of response isobolograms. MMUdR showed synergistic activity in combination with Ara-A and PAA but antagonistic activity in combination with EtUdR and IUdR against herpesviruses. Minimum toxic dose (concentration required to produce definite evidence of microscopic cytotoxicity in rapidly growing RK-13 cells) was determined for each compound and was found to be 512, 172, 64, 8, and less than 0.5 microgram/ml for MMUdR, PAA, Ara-A, EtUdR, and IUdR, respectively. MMUdR was found to have the maximum antiviral index against HSV-1 (512) and HSV-2 strains X-265 (102) and ATCC (85). Antiviral index was defined as the minimum toxic dose divided by the dose that reduced plaque numbers by 50%.
Synthesis and crosslinking of hyperbranched poly(n-nonyl acrylate) to form organogels (2015)

(2-Bromo-n-nonan-1-oxycarbonyl)ethyl acrylate was synthesized as an inimer for self-condensing vinyl polymerization (SCVP) to produce hyperbranched poly(n-nonyl acrylate), either as a homopolymer or as a copolymer with n-nonyl acrylate. The inimer was homopolymerized and copolymerized by atom transfer radical polymerization (ATRP) and activator generated by electron transfer ATRP to produce soluble polymers with broad polydispersities (up to Đ = 9.91), which is characteristic of hyperbranched polymers produced by SCVP. The resulting hyperbranched (co)polymers were crosslinked by atom transfer radical coupling in both one-pot and two-step procedures. The radical–radical crosslinking reaction is extremely efficient, resulting in hard plastic particles from the homopolymer of (2-bromo-n-nonan-1-oxycarbonyl)ethyl acrylate synthesized in bulk. Crosslinked organogels that swell in tetrahydrofuran were formed when the rate of crosslinking decreased using acetonitrile solutions. Dynamic shear and stress relaxation experiments demonstrated that the dry network behaves as a covalently crosslinked soft gel, with a glass transition at −50 °C according to differential scanning calorimetry. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015, 53, 2399–2410
ChemInform Abstract: Synthesis of the C1—C21 (C1′—C21′) Fragment of the Dimeric Polyketide Natural Product SCH 351448. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Abstract 14074: Machine Learning Applied on ECG Improves Cardiovascular Risk Prediction When Added to Coronary Artery Calcium Scoring in Patients With Cancer (2021)

Introduction: Patients with cancer are at increased cardiovascular (CV) risk. Both Coronary Artery Calcium (CAC) and 12-lead ECG features predict CV risk in the general population. However, the impact of these measures has not been investigated in patients with cancer. Hypothesis: We hypothesized that machine learning-based analysis of automatically-extracted ECG features, when added to CAC, can improve CV risk stratification in patients with cancer. Methods: We analyzed 1825 cancer patients with at least 1 CV risk factor who underwent CAC scoring and a standard 12-ECG as part of the CLARIFY (ClinicalTrials.gov Identifier: NCT04075162) registry. Events were defined as myocardial infarction, revascularization, stroke or death. A total of 445 ECG features were automatically extracted using a commercially available software (ECG Muse, GE healthcare). A LASSO-Cox method was used with 10-fold cross validation to select the most important ECG features with a novel ECG score derived using individual feature coefficients. We evaluated the ability of the combined ECG score with age, sex, and CAC to prognosticate a CV event in comparison to a model that was limited to age, sex, and CAC alone. The models were compared using an ANOVA test. Results: Over a median follow-up of 14 months, 224 patients had an event. Using the LASSO-Cox model, 25 ECG features were selected. The novel ECG score was associated with CV events (HR 8.6, 95% CI: 5.1-14.3, P&lt;0.001), which was not attenuated after adjusting for age, sex, and CACS (HR 7.3, 95% CI: 4.3-12.4, P&lt;0.001). Addition of ECG score to a model including age, sex, and CAC improved discrimination (C-Index 0.63 vs 0.72, P=0.0001). Conclusions: A novel ML-based ECG risk score using automatically extracted ECG features can improve CV risk stratification when added to CAC and demographics in patients with cancer.
Increase and Redistribution of Cardiac Mast Cells in Auricular Thrombosis (1995)

This study provides evidence that AUTHR is associated with MC increase and redistribution and MGF overexpression. The role of redistributed MC and their mediators in the pathophysiology of atrial thrombosis requires further investigation.
Dynamics of light-induced redox processes in microemulsion systems (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDynamics of light-induced redox processes in microemulsion systemsJ. Kiwi and M. GraetzelCite this: J. Am. Chem. Soc. 1978, 100, 20, 6314–6320Publication Date (Print):September 1, 1978Publication History Published online1 May 2002Published inissue 1 September 1978https://pubs.acs.org/doi/10.1021/ja00488a003https://doi.org/10.1021/ja00488a003research-articleACS PublicationsRequest reuse permissionsArticle Views149Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Sodium Taurocholate Stimulates Campylobacter jejuni Outer Membrane Vesicle Production via Down-Regulation of the Maintenance of Lipid Asymmetry Pathway (2019)

<i>Campylobacter jejuni</i> outer membrane vesicles (OMVs) contain numerous virulence-associated proteins including the cytolethal distending toxin and three serine proteases. As <i>C. jejuni</i> lacks the classical virulence-associated secretion systems of other enteric pathogens that deliver effectors directly into target cells, OMVs may have a particularly important role in virulence. <i>C. jejuni</i> OMV production is stimulated by the presence of physiological concentrations of the bile salt sodium taurocholate (ST) through an unknown mechanism. The maintenance of lipid asymmetry (MLA) pathway has been implicated in a novel mechanism for OMV biogenesis, open to regulation by host signals. In this study we investigated the role of the MLA pathway in <i>C. jejuni</i> OMV biogenesis with ST as a potential regulator. OMV production was quantified by analyzing protein and lipid concentrations of OMV preparations and OMV particle counts produced by nanoparticle tracking analysis. Mutation of <i>mlaA</i> which encodes the outer membrane component of the MLA pathway significantly increased OMV production compared to the wild-type strain. Detergent sensitivity and membrane permeability assays confirmed the increased OMV production was not due to changes in membrane stability. The presence of 0.2% (w/v) ST increased wild-type OMV production and reduced OMV size, but did not further stimulate <i>mlaA</i> mutant OMV production or significantly alter <i>mlaA</i> mutant OMV size. qRT-PCR analysis demonstrated that the presence of ST decreased expression of both <i>mlaA</i> and <i>mlaC</i> in <i>C. jejuni</i> wild-type strains 11168 and 488. Collectively the data in this study suggests <i>C. jejuni</i> can regulate OMV production in response to host gut signals through changes in expression of the MLA pathway. As the gut bile composition is dependent on both diet and the microbiota, this study highlights the potential importance of diet and lifestyle factors on the varying disease presentations associated with gut pathogen infection.
Impaired Pulmonary Host Defense in Mice Lacking Expression of the CXC Chemokine Lungkine (2001)

Lungkine (CXCL15) is a novel CXC chemokine that is highly expressed in the adult mouse lung. To determine the biologic function of Lungkine, we generated Lungkine null mice by targeted gene disruption. These mice did not differ from wild-type mice in their hematocrits or in the relative number of cells in leukocyte populations of peripheral blood or other tissues, including lung and bone marrow. However, Lungkine null mice were more susceptible to Klebsiella pneumonia infection, with a decreased survival and increased lung bacterial burden compared with infected wild-type mice. Histologic analysis of the lung and assessment of leukocytes in the bronchioalveolar lavage revealed that neutrophil numbers were normal in the lung parenchyma, but reduced in the airspace. The production of other neutrophil chemoattractants in the Lungkine null mice did not differ from that in wild-type mice, and neutrophil migration into other tissues was normal. Taken together, these findings demonstrate that Lungkine is an important mediator of neutrophil migration from the lung parenchyma into the airspace.
Pattern formation mechanism of zirconia nanoparticle resist used for extreme-ultraviolet lithography (Conference Presentation) (2018)

The performance of chemically amplified resist is approaching its physical limit with the reduction of feature sizes due to the acid diffusion needed for the solubility change of resist polymer. The line edge roughness (LER) of chemically amplified resists rapidly increases in the sub-10-nm-half-pitch region when the half-pitch is decreased. Also, the stochastic defect (pinching and bridges) generation is a significant concern for the high resolution patterning with high throughput. To solve these problems, the increase of the density of resist films is an important strategy. Metal oxide nanoparticle resists have attracted much attention as the next generation resist used for the high-volume production of semiconductor devices because of their high density property. However, the sensitization mechanism of the metal oxide nanoparticle resists is unknown. Understanding the sensitization mechanism is important for the efficient development of resist materials. In the previous study[1], the numbers of electron-hole pairs required for the solubility change of the resist films were estimated for a zirconia nanoparticle and a ligand shell, respectively. In this study, the pattern formation mechanism of zirconia nanoparticle resist was investigated. The elementary reactions possibly induced in the zirconia nanoparticle resist were investigated using a pulse radiolysis method. The pulse radiolysis is a powerful method to directly observe the kinetics of short-lived intermediates produced by an ionizing radiation. The pattern formation mechanism was assumed by integrating the elementary reactions. The resist patterns fabricated using an EUV exposure tool were analyzed on the basis of the assumed pattern formation mechanism. In the material design of metal oxide nanoparticle resists, it is important to efficiently use the electron-hole pairs generated in nanoparticles for the chemical change of ligand molecules. Acknowledgement This work was partially supported by Ministry of Economy, Trade and Industry (METI) and the New Energy and Industrial Technology Development Organization (NEDO). Reference [1] T. Kozawa, J. J. Santillan, and T. Itani, “Electron–hole pairs generated in ZrO2 nanoparticle resist upon exposure to extreme ultraviolet radiation”, Jpn. J. Appl. Phys. 57, 026501 (2018).
Kerr effect of two-medium layered systems (1990)

Detailed and practical expressions are given for the magneto-optical Kerr effect (MOKE) for various configurations of two media. One is a magneto-optic (MO) one, and the other is a nonmagnetic (NM) medium. For a system of two thick media with a single interface, with a first-order approximation in MOKE term Q, the Kerr function is determined by the product of a MOKE term Q and an optical term η. A second type of system includes a thin MO (or NM) layer deposited on a thick NM (or MO) substrate. For a MO/(NM-substrate) configuration, the Kerr function is related to the Kerr effects from the air/MO and MO/NM interfaces, and to the Faraday effects of the MO layer, as well as to interference effects. The enhancement factor can be expected to be large by proper choice of materials. For a NM/(MO-substrate) configuration, the total Kerr function is related to the Kerr effect from the NM/MO interface and can be enhanced by interference. The enhancement factor is expected to be less than one if the NM layer is strongly absorbing. Calculations of Kerr effects for examples of the PtMnSb/AuAl2 and Fe/Cu configurations are given. These indicate that the peaks shown in the onset region of the interband transitions of Cu can be attributed to a dramatic change of the refractive index in that region. The merits of a MO/(NM-metallic) structure have been evaluated, and indicate that a better Kerr enhancement effect can be achieved if the refractive index of the MO layer is larger than one and is much larger than that of the metallic material. A drawback to this configuration comes from the fact that a MO material with a large refractive index value usually is not expected to have a large intrinsic Kerr effect.
Sequencing tasks to minimize the effects of near-coincident faults in TMR controller computers (1996)

Although Triple Modular Redundancy (TMR) has been widely used to mask the effects of a single faulty module, it cannot tolerate coincident faults in multiple modules caused by a common source, such as an environmental disruption or malfunction of a shared component. We propose a method to eliminate or alleviate the effects of (near) coincident faults by sequencing tasks on different modules in a TMR system. Specifically, we develop an effective sequencing of tasks to simply place an "optimal" distance (in the sense of minimizing the mean number of faulty tasks due to TMR failures) between the copies of a task to be executed on different modules. Several examples are presented, showing significant improvements in reducing TMR failures with the proposed task sequencing.
Detecting eye-selective fMRI activity in the human primary visual cortex at 3T and 9.4T (2017)

Introduction The primary visual cortex of humans contains patches of neurons responding preferentially to stimulation of one eye (ocular dominance columns) (Adams et al., 2007). The majority of previous fMRI studies reporting eye-specific activity in V1 used magnetic field strengths of 4 T and higher (Cheng et al., 2001; Yacoub et al., 2007; Nasr et al., 2016). However, there have been reports of reliable eye-selective activations at 3 T (Haynes et al., 2005). Here we present preliminary results on the ability to detect eye-selective V1 activity using high-resolution fMRI at 3 T and 9.4 T. Methods BOLD signal of one healthy adult volunteer was measured at 3 T and 9.4 T using 2D GE-EPI (3 T: 1.5mm isotropic resolution, TR/TE/matrix/GRAPPA = 1720/30/128x128x24/R=3, 873 volumes; 9.4 T: 0.8mm isotropic resolution TR / TE / matrix / GRAPPA=2 s / 22 ms /230×230×40 / R=5, FLEET autocalibration (Polimeni et al., 2016), 900 volumes). Each eye was stimulated separately with a checkerboard flickering at 2 Hz for 18 s with 18 s breaks, viewed through a prism stereo display (Schurger, 2009). Structural scans (1mm3 for 3 T and 0.6 mm3 for 9.4 T) were acquired in each session for cortical surface reconstruction. All analyses were performed using FreeSurfer 6.0 and FS-FAST (Fischl, 2012). Functional data were motion-corrected, co-registered to the anatomy using boundary-based registration (Greve and Fischl, 2009) with 6 DOF for 3 T and 9 DOF locally constrained to V1 for 9.4 T, and analyzed using voxel-wise GLM with left eye, right eye and baseline regressors. Surface-based prediction of V1 location (Hinds et al., 2008) was used to label volume voxels belonging to V1 gray matter, and z-statistics of the contrast “left eye vs. right eye” were extracted from those voxels. Results We observed a more than two-fold increase in the percentage of eye-selective voxels and in run-to-run correlation of eye preference at ultrahigh field. Conclusion Increase in spatial resolution and improved BOLD point spread function at 9.4T allows for better detection of eye-selective signal related to ocular dominance columns.
Topical versus Systemic Antimicrobial Therapy for Treating Mildly Infected Diabetic Foot Ulcers: A Randomized, Controlled, Double‐Blinded, Multicenter Trial of Pexiganan Cream (2008)

Topical pexiganan might be an effective alternative to oral antibiotic therapy in treating diabetic patients with a mildly infected foot ulcer, and might reduce the risk of selecting antimicrobial-resistant bacteria.
Design of Low-Voltage MOSFET-Only&gt;tex&lt;$SigmaDelta$&gt;/tex&lt;Modulators in Standard Digital CMOS Technology (2004)

A design strategy of low-voltage high-linearity MOSFET-only /spl Sigma//spl Delta/ modulators in standard digital CMOS technology is presented. The modulators use substrate-biased MOSFETs in the depletion region as capacitors, linearized by different compensation techniques. This work shows the design, simulation and measured results of a number of MOSFET-only /spl Sigma//spl Delta/ modulators using different implementations of so called compensated depletion-mode MOS capacitors. The modulators are designed for the demands of speech band applications. The performance of the modulators proves the capability of compensated depletion-mode MOS capacitors to fulfill analog circuit requirements at low supply voltages with reduced processing efforts.
Laminin‐5 coating enhances epithelial cell attachment, spreading, and hemidesmosome assembly on Ti‐6Al‐4V implant material in vitro (1998)

Enhancement of epithelial cell attachment to laminin-5-coated titanium alloy (Ti-6Al-4V) implant material was evaluated in vitro. Protein analysis showed that Ti-6Al-4V has a high affinity for laminin-5 and adsorbed significantly more laminin-5 than laminin-1. DNA analysis showed that laminin-5 enhanced attachment of normal human epidermal keratinocytes (NHEK) to Ti-6Al-4V significantly more than did laminin-1 or uncoated controls. The effect of passivation on laminin-5 adsorption and activity on Ti-6Al-4V also was evaluated. Passivation had no significant effect on the amount of protein adsorbed; however, AFM, ESCA, and ToF-SIMS analyses suggested that passivation affects the conformation of adsorbed laminin-5. Although laminin-5 coating significantly enhanced rapid attachment of epithelial cells to both passivated and unpassivated Ti-6Al-4V, surface area measurements showed that cells spread on laminin-5-coated passivated Ti-6Al-4V covered a significantly larger surface area than cells spread on laminin-5-coated unpassivated samples. TEM analysis showed that cells formed significantly more hemidesmosomes on the surface of laminin-5 coated passivated than on the surface of laminin-5 coated unpassivated titanium alloy. The enhancement of rapid cell attachment, spreading, and hemidesmosome assembly on laminin-5-coated passivated samples may reflect better integration between epithelial cells and titanium alloy and thus may be predictive of long-term implant stability. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 41, 30–40, 1998.
Optical Coherence Tomography Angiography in pre-clinical Alzheimer’s disease (S16.001) (2018)

To determine whether retinal structural and vascular changes occur in pre-clinical Alzheimer’s disease
Analytical Model of HSDPA Throughput Under Nakagami Fading Channel (2009)

This paper presents an analytical model of the cell and user throughput of high-speed downlink packet access (HSDPA) that can be used to compare the performance and efficiency of various schedulers. The focus is on the proportional fair (PF), score-based (SB), and Max C/I schedulers. The radio channel is assumed to be a composite multipath/shadowing channel, with the path amplitude following a Nakagami distribution. The effect of the correlation between paths on the HSDPA throughput performance is taken into account in the modeling. The analytical model is confronted with a simulation using the NS2 network simulator and shown to provide reasonably close results to the simulation in view of the modeling assumptions.