gebhart/patrepeval huggingface dataset:
Evidences of anodic-oxidation reset mechanism in TiN\NiO\Ni RRAM cells (2011)

By means of conductance modeling, physical characterization, and stack engineering in 80nm-wide contact-hole cells, we clearly evidence for TiN\NiO\Ni RRAM systems that the reset switching corresponds to a partial Ni-rich filament constriction due to anodic oxidation mechanism at the interface with the Ni anode
Studies on Ribonucleoside Hydrogenphosphonates. Effect of a Vicinal Hydroxyl Function on the Stability of H-Phosphonate Diester Bond (1988)

Abstract Stability of hydrogenphosphonate diester bond in the presence of a free vicinal hydroxyl function has been investigated on the example of ribonucleoside H-phosphonates. It was found that H-phosphonate diesters undergo immediate intramolecular cyclization, both with or without a base, affording 2′, 3′-cyclic H-phosphonate diesters.
Bimetallic Catalysts: A Novel Approach to High‐Performance Aliovalent‐Substituted Catalysts—2D Bimetallic MOF‐Derived CeCuOx Microsheets (Small 42/2019) (2019)

In article number 1903525, Wei Han, King Lun Yeung, and co-workers develop a synthesis approach to binary metal oxides by controlled thermal transformation of bimetallic metal–organic framework precursors. The approach is capable of manipulating the morphology and structure of binary metal oxides as high-performance environmental catalysts for complete oxidation of volatile organic compounds under the conditions of low temperature and high humidity.
Additions and Corrections - Cyclo-additions of Ketenes with N-Fluorenylidenealklamine and -arylamine Oxides. Synthesis of Spirooxazolidinones and Spiroisoxazolidinones (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdditions and Corrections - Cyclo-additions of Ketenes with N-Fluorenylidenealklamine and -arylamine Oxides. Synthesis of Spirooxazolidinones and SpiroisoxazolidinonesMagid Abou-Gharbia and Madeleine JoullieCite this: J. Org. Chem. 1980, 45, 26, 5432Publication Date (Print):December 1, 1980Publication History Published online9 October 2003Published inissue 1 December 1980https://doi.org/10.1021/jo01314a605RIGHTS & PERMISSIONSArticle Views28Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (142 KB) Get e-Alerts Get e-Alerts
Experimental cerebral ischemia produces platelet aggregates (1979)

Human studies indicate that transient platelet abnormalities accompany acute cerebral ischemia. Although these abnormalities may precipitate the ischemi process, ischemia could also alter platelet function. Platelets were therefore studied in gerbils subjected to 1 hour of unilateral carotid artery occlusion. Venous blood from five clinically affected gerbils contained more aggregated platelets (37.8% +/- 6.4) than did blood from eight unaffected animals (11.1% +/- 3.0; p less than 0.01). Platelets labeled with 3H-serotonin were increased in ischemic brain; the ratio of radioactivity in the ipsilateral versus contralateral hemisphere was greater in eight affected (1.09 +/- 0.03) than in 19 unaffected (1.00 +/- 0.01; p less than 0.02) animals. The radioactive serotonin was located predominantly within blood vessels. Cerebral ischemia thus stimulated the formation of platelet aggregates, a response which could contribute to the ischemic process.
Disrupted plasma membrane localization of equilibrative nucleoside transporter 2 in the chemoresistance of human pancreatic cells to gemcitabine (dFdCyd) (2010)

Although the nucleoside pyrimidine analogue gemcitabine is the most effective single agent in the palliation of advanced pancreatic cancer, cellular resistance to gemcitabine treatment is a major problem in the clinical scene. To clarify the molecular mechanisms responsible for chemoresistance to gemcitabine, mRNA expression of the key enzymes including cytidine deaminase (CDA), deoxycytidine kinase (dCK), 5'-nucleotidase (NT5), equilibrative nucleoside transporter 1 and 2 (ENT1 and ENT2), dCMP deaminase (dCMPK), ribonucleotide reductase M1 and M2 (RRM1 and RRM2), thymidylate synthase (TS) and CTP synthase (CTPS) was examined. The interacellular uptake of gemcitabine was greatly impaired in the chemoresistant cell lines due to dysfunction of ENT1 and ENT2. Protein expression of ENT1 and ENT2 and their protein coding sequences were not altered. Immunohistochemical and western blot analyses revealed that localization of ENT2 on the plasma membrane was disrupted. These data suggest that the disrupted localization of ENT2 is one of causes of the impaired uptake of gemcitabine, resulting in a gain of chemoresistance to gemcitabine.
Engineering change protocols for behavioral synthesis (1999)

Rapid prototyping and development of in-circuit and FPGA-based emulators as key accelerators for fast time-to-market has resulted in a need for fast error correction mechanisms. The fabricated or emulated prototypes upon error diagnosis require quick and as much as possible flexible engineering change (EC). However, this problem has initiated research activity mainly in the logic synthesis domain. We introduce the first set of EC protocols for behavioral synthesis. The protocols support both the pre- and post-processing EC paradigms. In addition, instead of developing special algorithms for EC which is the adopted research model, as a key contribution, we show that using protocols which facilitate constraint manipulation of the initial design specification there is no need for development of specialized EC algorithms. The EC process is performed using the standard optimization algorithms on the modified design. Nevertheless, as shown on a number of behavioral synthesis tasks including: resource assignment, design partitioning, and operation scheduling, the approach provides variable and guaranteed flexibility for incremental synthesis with minimal hardware overhead.
Studies of the photoreactions of dodecacarbonyltriosmium with chlorocarbons and with triphenylphosphine in solution (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies of the photoreactions of dodecacarbonyltriosmium with chlorocarbons and with triphenylphosphine in solutionDavid R. Tyler, Mark Altobelli, and Harry B. GrayCite this: J. Am. Chem. Soc. 1980, 102, 9, 3022–3024Publication Date (Print):April 1, 1980Publication History Published online1 May 2002Published inissue 1 April 1980https://pubs.acs.org/doi/10.1021/ja00529a025https://doi.org/10.1021/ja00529a025research-articleACS PublicationsRequest reuse permissionsArticle Views148Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Biodiesel (2016)

Biodiesel production methods include acid, alkaline, two-step, supercritical methanol, and ultrasonic methods. Transesterification of the vegetable oil with the help of catalysts reduce the reaction duration but promotes complications in purification of biodiesel from catalysts and saponified products. Purification of biodiesel and separation of glycerol from the catalyst are necessary, but it would increase the cost of overall production process. With increasing the chain length, the miscibility between the oil and alcohol increases, thus, decreasing the reaction time but also making the separation of the esters difficult. The ultrasonic aided biodiesel production method can be a valuable tool for the transesterification of fatty acids. Ji et al. developed an alkali-catalyzed biodiesel production method with power ultrasonic that allows a short reaction time and high yield because of emulsification and cavitations of the liquid-liquid immiscible system. Contaminants and other minor components, due to incomplete reaction, are the major issues in the quality of biodiesel.
A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin (2007)

The effects of myristyl nicotinate (MN), a nicotinic acid derivative designed to deliver nicotinic acid to skin without vasodilatation, on subjects with photodamaged skin have been studied. MN increased skin cell nicotinamide adenine dinucleotide (NAD) by 25% (P = 0.001) demonstrating effective delivery of nicotinic acid to skin. Relative to placebo, MN treatment of photodamaged facial skin increased stratum corneum thickness by approximately 70% (P = 0.0001) and increased epidermal thickness by approximately 20% (P = 0.001). In two separate studies, MN treatment increased rates of epidermal renewal by 6% (P = 0.003) to 11% (P = 0.001) and increased the minimal erythemal dose by 8.9 (P = 0.07) and 10% (P = 0.05) relative to placebo. MN treatment resulted in reductions in the rates of transepidermal water loss (TEWL) of approximately 20% relative to placebo on cheeks (P = 0.012) and arms (P = 0.017) of study subjects. Results of a tape stripping challenge before and after MN treatment demonstrated a significant correlation (P = 0.03) between increased skin NAD content and resistance to changes in TEWL for MN treated but not placebo subjects. Rates of TEWL changed more rapidly and to a greater extent in atopic subjects compared with normal subjects. The results indicate that MN enhances epidermal differentiation and barrier function in skin, suggesting that this method of nicotinic acid delivery may prove useful in limiting progression of actinic skin damage and possibly in treating other conditions involving skin barrier impairment.
The Nucleus - A Report From The General Chairman Of The 1996 NSS/MIC (1997)

The 1996 Nuclear Science Symposium and Medical Imaging Conference was held between November 3 through November 9, 1996 in Anaheim, California. The conference followed in the footsteps of its predecessors in its success. The meeting, which convened at the Marriott Hotel in Anaheim in sunny Southern California, included technical sessions on a variety of topics on nuclear science, medical imaging, and nuclear power and a series of interesting short courses. Seven hundred sixty six attendees from around the world listened to two hundred eleven oral presentations and reviewed three hundred twenty eight posters covering the full range of symposium topics. The short course program which featured six short courses was attended by one hundred and two students. The conference also enjoyed two workshops, one on FASTCAMAC organized by Satish Dhawan, Yale University and another on the Applications and Methods of Compton Scattering organized by Tumay Turner, UC Riverside. The conference was further enriched by the participation of thirty five commercial exhibitors who presented various products relevant and vital to the attendees.
Carrier Depletion Silicon Ring Modulator Power Penalty Versus Power Coupling Coefficient (2018)

Carrier depletion ring modulators offer low power, low footprint, and high modulation speed in the perspective of future silicon photonic interconnects. However, the optical power penalty, which stands for the impact of this device on power budget, is sensitive to the ring power coupling coefficient. In this paper, we derive a relationship between the optical power and this device parameter using a simple analytical model. This model is first described and then compared to ring modulators fabricated in a 300-mm silicon photonic platform through systematic characterization of resonance depth, quality factor, and power penalty. A significant power penalty sensitivity to coupling coefficient variability as high as ~0.6 dB/% is evaluated from this model and confirmed by measurements. The limitations of this model are also discussed.
Functional genome-wide siRNA screen identifies KIAA0586 as mutated in Joubert syndrome (2015)

Defective primary ciliogenesis or cilium stability forms the basis of human ciliopathies, including Joubert syndrome (JS), with defective cerebellar vermis development. We performed a high-content genome-wide small interfering RNA (siRNA) screen to identify genes regulating ciliogenesis as candidates for JS. We analyzed results with a supervised-learning approach, using SYSCILIA gold standard, Cildb3.0, a centriole siRNA screen and the GTex project, identifying 591 likely candidates. Intersection of this data with whole exome results from 145 individuals with unexplained JS identified six families with predominantly compound heterozygous mutations in KIAA0586. A c.428del base deletion in 0.1% of the general population was found in trans with a second mutation in an additional set of 9 of 163 unexplained JS patients. KIAA0586 is an orthologue of chick Talpid3, required for ciliogenesis and Sonic hedgehog signaling. Our results uncover a relatively high frequency cause for JS and contribute a list of candidates for future gene discoveries in ciliopathies.
A STUDY OF HUMAN INFLUENCE BY FALLING OF GLASS DEBRIS (2019)

The purpose of this study is to evaluate the impact for human of falling glass debris. In this study, we measured the depth of the skin damaged by falling glass debris using a pig skin instead of human skin. The experimental results were evaluated with the weight and the falling velocity of glass debris, the depth and length of wounds, and the incidence of wounds. The depth and length of wounds are proportional to the weight of glass debris, and the depth of the wounds is inversely proportional to the length.
Ray-optical determination of strong backward coupling coefficients of waveguide grating devices (2000)

For calculation of strong backward coupling coefficients of waveguide gratings with arbitrary shapes, a rigorous method based on the ray-optics approach is proposed. Calculation accuracy depends on only on the limit of the rigorous coupled-wave theory used in the method.
Disappearance Rate of Catecholamines, Total Metanephrines, and Neuropeptide Y from the Plasma of Patients after Resection of Pheochromocytoma (2001)

A larger increase and a longer persistence of total metanephrines (reflecting predominantly sulfo-conjugated metanephrines) than catecholamines and NPY in plasma may contribute to their greater diagnostic accuracy in pheochromocytoma.
REGRESSION OF UVEAL MALIGNANT MELANOMAS FOLLOWING COBALT-60 PLAQUE (1985)

Parameters derived from computer analysis of digital radio-frequency (rf) ultrasound scan data of untreated uveal malignant melanomas were examined for correlations with tumor regression following cobalt-60 plaque. Parameters included tumor height, normalized power spectrum and acoustic tissue type (ATT). Acoustic tissue type was based upon discriminant analysis of tumor power spectra, with spectra of tumors of known pathology serving as a model. Results showed ATT to be correlated with tumor regression during the first 18 months following treatment. Tumors with ATT associated with spindle cell malignant melanoma showed over twice the percentage reduction in height as those with ATT associated with mixed/epithelioid melanomas. Pre-treatment height was only weakly correlated with regression. Additionally, significant spectral changes were observed following treatment. Ultrasonic spectrum analysis thus provides a noninvasive tool for classification, prediction and monitoring of tumor response to cobalt-60 plaque.
Supplementary Fig. 6 from Clinical Importance of the lncRNA <i>NEAT1</i> in Cancer Patients Treated with Immune Checkpoint Inhibitors (2023)

&lt;p&gt;Supplementary Fig. 6 NEAT1 expression in tumor-associated macrophages is associated with TNF-alpha signaling.&lt;/p&gt;
On-line reoptimization of filter designs for multivariate optical elements (2003)

An automated method for producing multivariate optical element (MOE) interference filters that are robust to errors in the reactive magnetron sputtering process is described. Reactive magnetron sputtering produces films of excellent thickness and uniformity. However, small changes in the thickness of individual layers can have severe adverse effects on the predictive ability of the MOE. Adaptive reoptimization of the filter design during the deposition process can maintain the predictive ability of the final filter by changing the thickness of the undeposited layers to compensate for the errors in deposition. The merit function used, the standard error of calibration, is fundamentally different from the standard spectrum matching. This new merit function allows large changes in the transmission spectrum of the filter to maintain performance.
A Comparative Study of Matrix Completion and Recovery Techniques for Human Pose Estimation (2018)

We present a comparative study of three matrix completion and recovery techniques, applied to the problem of human pose estimation. Human pose estimation algorithms may exhibit estimation noise or may completely fail to provide estimates for some joints. A post-process is often employed to recover the missing joints' locations from the available ones, typically by enforcing kinematic constraints or by using a prior learned from a database of natural poses. Matrix completion and recovery techniques fall into the latter category and operate by filling-in missing entries of a matrix, with the available/non-missing entries being potentially corrupted by noise. We compare the performance of three such techniques in terms of the estimation error of their output as well as their runtime under varying parameters. We conclude by recommending use cases for each of the compared techniques.
Uniform Bit and Power Allocation with Subcarrier Selection for Coded OFDM Systems (2011)

In this paper, the problem of adaptive bit and power allocation for coded OFDM systems is considered. With emphasis on low feedback overhead and low complexity, we present a simple adaptive allocation technique, where data are transmitted only using the strongest subcarriers with uniform power and uniform constellation size. Due to the reduced number of used subcarriers, a fraction of coded bits are not transmitted, while keeping the information bit rate unchanged. The problem of bit and power allocation to minimize packet error rate (PER) reduces to determine the constellation size and the number of unused subcarriers. The optimal solution provides a good tradeoff among average SNR, coding gain, and demapping loss. To solve the problem, we introduce an effective SNR maximization approach. Numerical results show that the proposed scheme significantly improves PER performance.
Redirection of the Glycolytic Flux Enhances Isoprenoid Production in Saccharomyces cerevisiae (2019)

Sufficient supply of reduced nicotinamide adenine dinucleotide phosphate (NADPH) is a prerequisite of the overproduction of isoprenoids and related bioproducts in Saccharomyces cerevisiae. Although S. cerevisiae highly depends on the oxidative pentose phosphate (PP) pathway to produce NADPH, its metabolic flux toward the oxidative PP pathway is limited due to the rigid glycolysis flux. To maximize NADPH supply for the isoprenoid production in yeast, upper glycolytic metabolic fluxes are reduced by introducing mutations into phosphofructokinase (PFK) along with overexpression of ZWF1 encoding glucose-6-phosphate (G6P) dehydrogenase. The PFK mutations (Pfk1 S724D and Pfk2 S718D) result in less glycerol production and more accumulation of G6P, which is a gateway metabolite toward the oxidative PP pathway. When combined with the PFK mutations, overexpression of ZWF1 caused substantial increases of [NADPH]/[NADP<sup>+</sup> ] ratios whereas the effect of ZWF1 overexpression alone in the wild-type strain is not noticeable. Also, the introduction of ZWF1 overexpression and the PFK mutations into engineered yeast overexpressing acetyl-CoA C-acetyltransferase (ERG10), truncated HMG-CoA reductase isozyme 1 (tHMG1), and amorphadiene synthase (ADS) leads to a titer of 497 mg L<sup>-1</sup> of amorphadiene (3.7-fold over the parental strain). These results suggest that perturbation of upper glycolytic fluxes, in addition to ZWF1 overexpression, is necessary for efficient NADPH supply through the oxidative PP pathway and enhanced production of isoprenoids by engineered S. cerevisiae.
Inhibition of Circulating Dipeptidyl Peptidase 4 Activity in Patients with Metastatic Prostate Cancer (2014)

Cancer is responsible for many deaths and is a major source of healthcare expenditures. The identification of new, non-invasive biomarkers might allow improvement of the direct diagnostic or prognostic ability of already available tools. Here, we took the innovative approach of interrogating the activity of exopeptidases in the serum of cancer patients with the aim of establishing a distinction based on enzymatic function, instead of simple protein levels, as a means to biomarker discovery. We first analyzed two well-characterized mouse models of prostate cancer, each with a distinct genetic lesion, and established that broad exopeptidase and targeted aminopeptidase activity tests reveal proteolytic changes associated with tumor development. We also describe new peptide-based freeze-frame reagents uniquely suited to probe the altered balance of selected aminopeptidases, as opposed to the full array of exopeptidases, and/or their modulators in patient serum or plasma. One particular proteolytic activity was impaired in animals with aggressive disease relative to cancer-free littermates. We identified the protease in question as dipeptidyl peptidase 4 (DPP4) by analyzing selected knockout mice and evaluating the effect of specific inhibitors. DPP4 activity was also reduced in the sera of patients with metastatic prostate cancer relative to patients with localized disease or healthy controls. However, no significant differences in DPP4 serum levels were observed, which established the loss of activity as the result of impaired enzymatic function. Biochemical analysis indicated that reduced activity was the result not of post-translational modifications or allosteric changes, but instead of a low-molecular-weight inhibitor. After we adjusted for age and total prostate-specific antigen, reduced DPP4 activity remained a significant predictor of cancer status. The results of this proof-of-principle study suggest that DPP4 activity might be a potential blood-based indicator of the presence of metastatic cancer of prostatic origin, either by itself or, more likely, as a means to improve the sensitivity and specificity of existing markers.