gebhart/patrepeval huggingface dataset:
Midregional pro-Adrenomedullin in addition to b-type natriuretic peptides in the risk stratification of patients with acute dyspnea: an observational study (2009)

MR-proADM alone or combined to NT-proBNP has a potential to assist clinicians in risk stratifying patients presenting with acute dyspnea regardless of the underlying disease.
Shared Navigational Control and User Intent Detection in an Intelligent Walker. (2005)

This paper describes the navigational control scheme used in the CO-Operative Locomotion Aide (COOL Aide), an intelligent walker designed to assist the elderly or the disabled with normal, and routine walking tasks. Navigation is achieved through a shared control architecture that recognizes the goals of both the human user and the walker. The control system is based on a synthesis of heuristic logic that exploits a dynamic model of walker system that can detect sliding and loss of walker stability. The model is used to predict the user’s intended path, based on the history of information collected from the walker’s sensors. Sensor information consists primarily of the forces and moments the user exerts on the walker’s handles during the natural assisted walking process, as well as the user’s local environment. Based on the model’s prediction, the walker’s state, and the walker’s environment, the control system can confirm or overturn the hypotheses of user’s intent it put forward and can influence the walker’s heading if the system believes the user will not reach the perceived intended goal unassisted. This paper discusses the model’s use in the shared control scheme and the mechanism for detecting/handling errors in the model’s predictions.
Extracellular Pax6 Regulates Tangential Cajal–Retzius Cell Migration in the Developing Mouse Neocortex (2019)

The embryonic mouse cortex displays a striking low caudo-medial and high rostro-lateral graded expression of the homeoprotein transcription factor Pax6, which presents both cell autonomous and direct noncell autonomous activities. Through the genetic induction of anti-Pax6 single-chain antibody secretion, we have analyzed Pax6 noncell autonomous activity on the migration of cortical hem- and septum-derived Cajal-Retzius (CR) neurons by live imaging of flat mount developing cerebral cortices. Blocking extracellular Pax6 disrupts tangential CR cell migration patterns by decreasing the distance traveled and changing both directionality and depth at which CR cells migrate. Tracking of single CR cells in mutant cortices revealed that extracellular Pax6 neutralization enhances contact repulsion in medial regions yet reduces it in lateral regions. This study demonstrates that secreted Pax6 controls neuronal migration and distribution and suggests that it acts as a bona fide morphogen at an early stage of cerebral cortex development.
Assigning parameter estimates for N -survivorprocessing (1999)

In an attempt to improve N-survivor processing (NSP), which lies between per-survivor processing and tentative decisions, a new algorithm is proposed for assigning parameter estimates to survivors. The proposed algorithm considers the history of the survivors in a trellis diagram by evaluating the distance between the hypothesised input vectors that contain the path history. It will be shown through computer simulation that NSP employing the proposed algorithm can outperform the original version.
The therapeutic potential of Scutellaria baicalensis for the treatment of obesity-driven hepatocellular carcinoma (2020)

Obesity is closely associated with non-alcoholic fatty liver disease which will develop into hepatocellular carcinoma (HCC). Obesity per se is also an independent risk factor for HCC. Lipotoxicity, adipose tissue remodeling, modulation of immune infiltrates in tumors and adipocytes, changes in intestinal microbiome all contribute to the pathogenesis of HCC under obesity condition. These obesity-associated pathogenic factors increase the clinical challenges for the management of obesity-driven HCC. Scutellaria baicalensis Georgi is a perennial herb of the Lamiaceae family. It is clinically used for the treatment of hyperlipemia, atherosclerosis, hypertension and inflammatory diseases. This article reviews the current findings on the molecular basis of the anti-HCC effects of S. baicalensis and its bioactive compounds, and discuss whether the treatments can alleviate or ameliorate the obesity-associated pathogenic factors. This is the first review unravels the therapeutic potential of S. baicalensis and its bioactive compounds for the treatment obesity-driven HCC.
Socially-aware interference mitigation game in body-to-body networks (2014)

Abstract—Wireless wearable devices have recently gained in-creasing attention from industry in fields such as health, fitness, and entertainment. In this paper, we consider a dynamic system composed of several Body-to-Body Networks (BBNs) based on wearable technology, and we analyze the joint mutual and cross-technology interference problem due to the utilization of a limited number of channels by different transmission technologies (i.e., ZigBee and WiFi) sharing the same radio spectrum. To this end, we propose a game theoretical approach to address the problem of Socially-aware Interference Mitigation (SIM) in BBNs. Our approach considers a two-stage channel allocation scheme: a BBN-stage for inter-WBANs ’ communications and a WBAN-stage for intra-WBAN communications, involving mutual and cross-technology considerations at each stage. We develop best response algorithms that converge fast to Nash equilibrium points. Simulation results show the efficiency of SIM game in optimizing the channel allocation in BBNs.
Self-Selection of Agricultural By-Products and Food Ingredients by Tenebrio molitor (Coleoptera: Tenebrionidae) and Impact on Food Utilization and Nutrient Intake (2020)

Nutrient self-selection was used to determine optimal intake ratios of macro-nutrients by <i>Tenebrio molitor</i> L. larvae. Self-selection experiments consisted of 9 combinations (treatments) of 8 ingredients, from a total of 20 choices, radially distributed in a multiple-choice arena presented to groups of 100 <i>T. molitor</i> larvae (12th-13th instar). Larvae freely selected and feed on the pelletized ingredients for a period of 21 days at 27 °C, 75% RH, and dark conditions. Consumption (g) of each ingredient, larval live weight gained (mg), and frass production were recorded and used to calculate food assimilation and efficiency of conversion of ingested food. The macro-nutrient intake ratios were 0.06 ± 0.03, 0.23 ± 0.01, and 0.71 ± 0.03 for lipid, protein, and carbohydrate, respectively on the best performing treatments. The intake of neutral detergent fiber negatively impacted food assimilation, food conversion and biomass gain. Food assimilation, food conversion, and biomass gain were significantly impacted by the intake of carbohydrate in a positive way. Cabbage, potato, wheat bran, rice bran (whole and defatted), corn dry distillers' grain, spent brewery dry grain, canola meal and sunflower meal were considered suitable as <i>T. molitor</i> diets ingredients based on their relative consumption percentages (over 10%) within treatment.
Fingerprinting-Based Indoor Localization With Commercial MMWave WiFi: A Deep Learning Approach (2020)

Existing fingerprint-based indoor localization uses either fine-grained channel state information (CSI) from the physical layer or coarse-grained received signal strength indicator (RSSI) measurements. In this paper, we propose to use a mid-grained intermediate-level channel measurement - spatial beam signal-to-noise ratios (SNRs) that are inherently available and defined in the IEEE 802.11ad/ay standards - to construct the fingerprinting database. These intermediate channel measurements are further utilized by a deep learning approach for multiple purposes: 1) location-only classification; 2) simultaneous location-and-orientation classification; and 3) direct coordinate estimation. Furthermore, the effectiveness of the framework is thoroughly validated by an in-house experimental platform consisting of 3 access points using commercial-off-the-shelf millimeter-wave WiFi routers. The results show a 100% accuracy if the location is only interested, about 99% for simultaneous location-and-orientations classification, and an averaged root mean-square error (RMSE) of 11.1 cm and an average median error of 9.5 cm for direct coordinate estimate, greater than 2-fold improvements over the RMSE of 28.7 cm and median error of 23.6 cm for RSSI-like single SNR-based localization.
Low-resource ECDSA implementation for passive RFID tags (2010)

With the introduction of security functionality RFID is an emerging technology that has high potential in numerous of applications. In this paper we investigate the hardware implementation of public-key cryptography for passive RFID tags. We generate digital signatures according to the ECDSA algorithm for authentication of RFID tags in open-loop scenarios. The implementation of ECDSA is based on the recommended F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">p160</sub> SECG elliptic curve SECP160r1. In order to meet the fierce constraints concerning power consumption and chip area our design has a 16-bit word size. The hardware module consists of a latch based 90 × 16-bit dual-port RAM, a datapath with a 16 × 16-bit multiply-accumulate unit and a dedicated finite-state machine. The design requires a chip area of 18 247 GEs and has a power consumption of 860 μW at 1MHz using a 0.35 μm CMOS technology. In total, an ECDSA signature requires 511 864 clock cycles.
Inhibition of Leukocyte Migration by a Staphylococcal Factor (1969)

Cell wall mucopeptide isolated from virulent strains of Staphylococcus aureus has previously been found to potentiate subcutaneous staphylococcal lesions in mice. This cell wall fraction was found to inhibit the migration of polymorphonuclear leukocytes toward a chemotactic stimulus, as tested by the micropore filter chamber technique. A close correlation was shown to exist between in vivo "mouse virulence" of staphylococcal strains and the in vitro inhibition of leukocyte migration by the cell wall factor.
Hydrogen Boride Sheets as Reductants and the Formation of Nanocomposites with Metal Nanoparticles (2020)

Hydrogen boride (HB) sheets have recently been synthesized as new two-dimensional materials composed of boron and hydrogen. This study reports a new role of HB sheets as reductants. Ultraviolet–visible spectroscopy was undertaken for a mixture of HB sheets with several metal ions in solution. The sheets had a redox potential between −0.277 and −0.257 V versus standard hydrogen electrode (SHE). We subsequently demonstrated the facile formation of HB sheet nanocomposites with metal nanoparticles using this reduction property. Herein, we report a new role of HB sheets as reductants. Ultraviolet–visible spectroscopy was conducted for a mixture of HB sheets with several metal ions in solution. The redox potential of HB sheets was between −0.277 and −0.257 V versus SHE. We then demonstrated the facile formation of HB sheet nanocomposites with metal nanoparticles using its reducing property.
Toll‐like receptor stimulation as a third signal required for activation of human naive B cells (2006)

According to the current model, naive B cell activation is dependent on the sequential integration of two signals: B cell receptor (BCR) cross-linking by antigen, followed by cognate interaction with helper T cells through an immunological synapse. Using an improved method to purify human naive B cells we found that BCR stimulation and T cell help induced initial cell division but were not sufficient to promote survival and differentiation thus leading to abortive proliferation of naive B cells. Extensive B cell proliferation, isotypic switch and differentiation to immunoglobulin (Ig)-secreting cells was induced by addition of microbial products that trigger any of the Toll-like receptors (TLR) that are up-regulated in naive B cells upon BCR triggering. TLR agonists acted directly on B cells and were required irrespective of the nature of the T helper cells present. Supernatants of dendritic cells (DC) stimulated by DC-specific TLR agonists were also capable of enhancing B cell responses although to a much lower and variable extent. These results indicate that human naive B cell activation is critically dependent on innate stimuli acting optimally on TLR expressed by B cells. The coupling of BCR stimulation to TLR expression endows the human system with a high degree of specificity since it allows focusing of innate signals only on antigen-stimulated B cells.
A New Vision for Preventing Pressure Ulcers: Wearable Wireless Devices Could Help Solve a Common-and Serious-Problem (2018)

With an aging population, the incidence and prevalence of wound problems is on the rise. Bedsores (also known as pressure ulcers or decubitus ulcers) are painful, take months to heal, and, for many patients, never do, leading to other health problems. The condition has become so acute that treating bedsores is now a significant burden on the healthcare system. An estimated 2.5 million pressure ulcers are treated in U.S. hospitals each year, adding US$11 billion annually to health care costs.
Genetic Organization of the aprX-lipA2 Operon Affects the Proteolytic Potential of Pseudomonas Species in Milk (2020)

Psychrotolerant <i>Pseudomonas</i> species are a main cause of proteolytic spoilage of ultra-high temperature (UHT) milk products due to the secretion of the heat-resistant metallopeptidase AprX, which is encoded by the first gene of the <i>aprX-lipA2</i> operon. While the proteolytic property has been characterized for many different <i>Pseudomonas</i> isolates, the underlying <i>aprX-lipA2</i> gene organization was only described for a few strains so far. In this study, the phylogenomic analysis of 185 <i>Pseudomonas</i> type strains revealed that the presence of <i>aprX</i> is strongly associated to a monophylum composed of 81 species, of which 83% carried the <i>aprX</i> locus. Furthermore, almost all type strains of known milk-relevant species were shown to be members of the three monophyletic groups <i>P. fluorescens</i>, <i>P. gessardii</i>, and <i>P. fragi</i>. In total, 22 different types of <i>aprX-lipA2</i> genetic organizations were identified in the genus, whereby 31% of the species tested carried the type 1 operon structure consisting of eight genes (<i>aprXIDEF prtAB lipA2</i>). Other genetic structures differed from type 1 mainly in the presence and location of genes coding for two lipases (<i>lipA1</i> and <i>lipA2</i>) and putative autotransporters (<i>prtA</i> and <i>prtB</i>). The peptidase activity of 129 strains, as determined on skim milk agar and in UHT-milk, correlated largely with different <i>aprX-lipA2</i> gene compositions. Particularly, isolates harboring the type 1 operon were highly proteolytic, while strains with other operon types, especially ones lacking <i>prtA</i> and <i>prtB</i>, exhibited significantly lower peptidase activities. In conclusion, the phylogenomic position and the <i>aprX-lipA2</i> gene organization specify the proteolytic potential of <i>Pseudomonas</i> isolates. In addition, however, an interplay of several environmental factors and intrinsic traits influences production and activity of AprX, leading to strain-specific proteolytic phenotypes.
Semicontinuous silver films as an ultra-sensitive Raman biosensor for recognition of insulin variants (2003)

Protein analysis is playing an important role in various biomedical applications. Performing such analysis at the molecular level is critical for further advancements in diagnostics. New instruments for measuring protein primary and secondary structures are in great demand for synthesis, purification, and recognition of proteins. Human insulin (humulin) and its artificial substitute humalog used for people with diabetes, are among particularly important proteins. There is a tiny difference in structures of these two proteins: the humalog structure can be obtained from humulin by interchanging lysine and proline amino acids at the B28 and B29 positions. These two proteins have the same mass, but because of the small structural difference, rather different properties, including their medical activity. Raman spectroscopy is known to have a high sensitivity in detecting bond structures of molecules, and thus it can be a powerful means for detection even smallest differences. Furthermore, surface-enhanced Raman scattering (SERS), providing a dramatic increase for Raman signals, makes possible analysis even at very minute protein quantities. In our experiments, we demonstrated that SERS substrates based on semicontinuous silver films [1] can be successfully used as highly sensitive substrates for distinguishing Humalog and Humulin at the sub-monolayer density, 80 fmol/mm2.
A Tunable Matched Fiber Grating Filter For Chemical Detection (1997)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. D. Prohaska and R. A. Lieberman, "A Tunable Matched Fiber Grating Filter For Chemical Detection," in 12th International Conference on Optical Fiber Sensors, Vol. 16 of 1997 OSA Technical Digest Series (Optica Publishing Group, 1997), paper PDP1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Microfabricated therapeutic actuators (2023)

Microfabricated therapeutic actuators are fabricated using a shape memory polymer (SMP), a polyurethane-based material that undergoes a phase transformation at a specified temperature (Tg). At a temperature above temperature Tg material is soft and can be easily reshaped into another configuration. As the temperature is lowered below temperature Tg the new shape is fixed and locked in as long as the material stays below temperature Tg. Upon reheating the material to a temperature above Tg, the material will return to its original shape. By the use of such SMP material, SMP microtubing can be used as a release actuator for the delivery of embolic coils through catheters into aneurysms, for example. The microtubing can be manufactured in various sizes and the phase change temperature Tg is determinate for an intended temperature target and intended use.
Liver sulfatide-reactive type II NKT cells recognize endogenous phospholipids (2014)

Meeting abstracts NKT cells are a unique population of T cells that recognize lipid antigens presented by a nonclassical MHC-like molecule CD1d. There are two types of NKT cells, type I and type II. Our group previously showed that type I NKT cells enhance and type II NKT cells suppress anti-tumor
Efficient Byzantine Fault Tolerance for Scalable Storage and Services (2009)

Distributed systems experience and should tolerate faults beyond simple component crashes as such systems grow in size and importance. Unfortunately, tolerating arbitrary faults, also known as Byzantine faults, poses several challenges to system designers, often limiting performance, requiring additional hardware, or both. This dissertation presents new protocols that provide substantially better performance than previously demonstrated. The Byzantine fault-tolerant erasure-coded block storage protocol proposed in this thesis provides 40 % higher write throughput than the best prior approach. The Byzantine fault-tolerant replicated state machine provides a factor of 2.2–2.9 times
Shot noise influence in reconstructed phase images SNR in digital holographic microscopy (2005)

We present a study based on simulations describing how shot noise, an intrinsic part of the recording process with a digital camera, influences the quality of the reconstructed phase images under different beams intensities configurations.
Gene transfer into adult rat spinal cord using naked plasmid DNA and ultrasound microbubbles (2005)

An ultrasound intensity of 0.4-0.5 W/cm2 significantly increased luciferase expression up to approximately 15-60-fold at the insonated level as compared to naked plasmid DNA alone. Luciferase activity could be detected at least up to 7 days after transfection, while the expression level was almost returned to undetectable level at 14 days after transfection. The transfected cells were mainly meningeal cells in the surface of insonated spinal cord. There was no obvious evidence of worsening of neurological deficits as compared to rats transfected with naked plasmid DNA alone or untransfected rats. Similarly, successful gene transfer was also achieved in the insonated T9-10 spinal cord after spinal cord injury. Overall, the present study demonstrated the feasibility of ultrasound microbubbles-mediated plasmid DNA transfer into the target level of the spinal cord.
[Cerebral circulation and oxygen metabolism in children's "moyamoya" diseases]. (1988)

Regional (r) CBF, rOEF, rCMRO2, rCBV in five cases of "moyamoya" disease in children were studied with PET scan, using 15O steady-state methods. All cases showed ischemic symptoms such as TIA, RIND and minor stroke. Intervals from the latest ictus to PET ranged from 3 days to 3 years 6 months. Control data were obtained through PET studies in 8 normal volunteers. Physiological parameters described above, in cerebral gray matter, white matter and basal ganglia were calculated and were carefully compared with normal control. Apparently low density area in X-ray CT were excluded from this analysis. Although rCBF showed a little bit higher value in all gray, white and basal ganglia, it was not statistically significant. rCBV of "moyamoya" disease significantly increased in gray, white and basal ganglia. The calculated value of CBF/CBV is considered to be an index of perfusion pressure and is the reversed value of transit time. This value was significantly decreased in "moyamoya" disease in every three region. Under the normal autoregulation, further decrease of perfusion pressure initiate increase of rOER and also decrease of rCBF. In spite of reduction of CBF/CBV, rOER was not significantly increased in every three region. Hence the cerebral circulation in children's "moyamoya" disease of ischemic type appears to be characterized by the mild decrease of perfusion pressure, dilated resistant vessels and prolonged circulation time.
Writing Your Next Medicinal Chemistry Article: Journal Bibliometrics and Guiding Principles for Industrial Authors (2020)

Writing scientific articles is immensely rewarding but challenging. This Perspective provides the medicinal chemist with background and advice on the art and process of writing manuscripts and complements the instructions to authors provided by journals. Included are many tips that we wish we had known when we first started writing. Bibliometric data from seven medicinal chemistry journals between 2000 and 2019 are collated including <i>Bioorganic and Medicinal Chemistry Letters</i> and the <i>Journal of Medicinal Chemistry</i>. Although the overall number of articles has doubled, the output from 23 large pharma companies in the past decade has dropped significantly. Commentary is given on the entire process of writing original scientific articles, opinion articles, and reviews. Examples from our own papers and experience are shared including what typically motivates the writer, challenges commonly encountered, and how we find time to write. Finally, the benefits derived from much wider publishing of industrial medicinal chemistry are described.
Supplementary Data from A Phase I Dose-Escalation Study of Danusertib (PHA-739358) Administered as a 24-Hour Infusion with and without Granulocyte Colony-Stimulating Factor in a 14-Day Cycle in Patients with Advanced Solid Tumors (2023)

Supplementary Data from A Phase I Dose-Escalation Study of Danusertib (PHA-739358) Administered as a 24-Hour Infusion with and without Granulocyte Colony-Stimulating Factor in a 14-Day Cycle in Patients with Advanced Solid Tumors