gebhart/patrepeval huggingface dataset:
O-linked mucin-type glycosylation in breast cancer (2018)

Changes in mucin-type O-linked glycosylation are seen in over 90% of breast cancers where increased sialylation is often observed and a change from branched glycans to linear glycans is often seen. There are many mechanisms involved including increased/altered expression of glycosyltransferases and relocalisation to the endoplasmic reticulum of the enzymes responsible for the addition of the first sugar, <i>N</i>-acetyl-d-galactosamine. It is now becoming clear that these changes can contribute to tumour growth and progression by modulating the micro-environment through glycan-sensing lectins expressed on immune cells, by modulating interactions with tumour surface receptors and by binding to selectins. The understanding of how changes in mucin-type O-linked glycosylation influence tumour growth and progression reveals new potential targets for therapeutic intervention in the treatment of breast cancer.
Deghosting of arbitrarily depth-varying marine hydrophone streamer data by time-space domain modelling (2014)

Summary We present a novel method for receiver- and source-side deghosting of conventional hydrophone streamer data towed at arbitrary variable depths. The method uses a time-space domain finite-difference solution to the wave equation with pressure field boundary conditions to predict and remove ghosts. Since it operates in the time domain, the method is unaffected of any number of notches in the frequency spectrum of the data and will deghost “through notches”. Apart from the acquired hydrophone data, the method relies on the depth profile of the streamer.
System integration in modularization and standardization programs (2015)

The Engineer-To-Order business, which encompasses companies producing a broad range of capital goods, is becoming increasingly complex. In order to improve their profitability, engineering organizations in this business use standardization programs. While decomposition aspects in such programs are already in an advanced state, the integration of components, modules or subsystems into a customer-specific solution as well as integration of engineering disciplines, life cycle phases and stakeholders are critical but yet neglected aspects. Therefore, the focus of this contribution lies on the role of system integration in standardization programs. It identifies various objects for integration from which seven types of integration with regard to modularization and standardization programs are derived. The analyses of this contribution are based on a literature review and case studies of six standardization programs.
Low‐Cost Higher Loading of a Sulfur Cathode (2015)

To increase the sulfur content/loading, trap the soluble Li2Sx intermediates, and improve the cycling stability of Li/S batteries, 3D-interlaced, nitrogen-doped, micro/mesoporous carbon-fiber free standing membranes are developed. Extendable multilayers' stacking of the carbon fibers not only allows a greater sulfur content/loading on the cathode, but also helps to better mitigate the diffusion of polysulfide. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Prokaryotic Community Dynamics during the Start-Up of a Full-Scale BIO4GAS Digester (2015)

The full-scale start-up of a novel BIO4GAS digester system, a highly economic, small-scale biogas plant was monitored for 6 months. The digester was loaded with cattle manure, and a new slow temperature increase strategy (12–37°C at 0.25°C d−1) was tested, rendering a daily methane yield of 289±148 mL g−1 volatile solids. Stable biogas production, pH, and high reduction of volatile fatty acids (from 5.2 to 0.6 g L−1) indicated a well working process. The prokaryotic community was monitored by cloning and quantitative real-time PCR of the 16S rRNA gene. Archaeal diversity decreased at the taxonomic class level, whereas the bacterial community was affected only up to the family level. A shift from hydrogenotrophic methanogens toward a consortium dominated by metabolically versatile methanogens occurred with Methanosarcina outcompeting Methanobrevibacter under the changing conditions of volatile fatty acid concentrations. Main bacterial phyla (Firmicutes, Bacteroidetes, and Proteobacteria) did not change during the start-up; however, minor populations of cellulose-degraders (Ruminococcaceae), syntrophic fatty acid oxidizers (Syntrophomonas), and acetogens (Sedimentibacter) established. The results provide experimental evidence of a dynamic archaeal community and a relatively stable bacterial community during dramatic environmental changes of a successful reactor start-up.
Spin Stand Heat Assisted Magnetic Recording Experiments Using Near Field Waveguide Optics Fabricated on Al_2O_3-TiC Sliders (2005)

This paper describes a series of spin stand experiments using a novel 2D waveguide near field optical condenser. The effects of laser power, external field and alignment on the play back signal are reported.
Germanium Mid-Infrared Photonic Devices data (2016)

&lt;span style='white-space:pre-line'&gt;Excel file containing the data for the Germanium Mid-Infrared Photonic Devices. This being a review paper, only the data for the previously unpublished work is included.&#13;\n&#13;\nFunded by Royal Society (UF120053, Mid-IR Silicon Photonics Sources, Detectors and Sensors)&lt;/span&gt;
Stokes Vector Spectroscopy of Nonlinear Depolarized Light (2019)

Experimental Stokes vector spectroscopy characterizes polarization state noise in nonlinear fiber transmission. Noise bandwidths of a few MHz are observed from XPM-blurred receive SOPs using a polarization scrambling interferometer. This method can detect data pattern correlations among WDM channels that contribute to performance degradations in signalling.
Adaptive Enhanced Cell-ID Fingerprinting Localization by Clustering of Precise Position Measurements (2007)

Cell identity (cell ID) is the backbone positioning method of most cellular-communication systems. The reasons for this include availability wherever there is cellular coverage and an instantaneous response. Due to these advantages, technology that enhances the accuracy of the method has received considerable interest. This paper presents a new adaptive enhanced cell-ID (AECID) localization method. The method first clusters high-precision position measurements, e.g., assisted-GPS measurements. The high-precision position measurements of each cluster are tagged with the same set of detectable neighbor cells, auxiliary connection information (e.g., the radio-access bearer), as well as quantized auxiliary measurements [e.g., roundtrip time]. The algorithm proceeds by computation and tagging of a polygon of minimal area that contains a prespecified fraction of the high-precision position measurements of each tagged cluster. A novel algorithm for calculation of a polygon is proposed for this purpose. Whenever AECID positioning is requested, the method first looks up the detected neighbor cells and the auxiliary connection information and performs required auxiliary measurements. The polygon corresponding to the so-obtained tag is then retrieved and sent in response to the positioning request. The automatic self-learning algorithm provides location results in terms of minimal areas with a guaranteed confidence, adapted against live measurements. The AECID method can, therefore, also be viewed as a robust fingerprinting algorithm. The application to fingerprinting is illustrated by an example where quantized path-loss measurements from six base stations are combined.
Graph link prediction in computer networks using Poisson matrix factorisation (2020)

Graph link prediction is an important task in cyber-security: relationships between entities within a computer network, such as users interacting with computers, or system libraries and the corresponding processes that use them, can provide key insights into adversary behaviour. Poisson matrix factorisation (PMF) is a popular model for link prediction in large networks, particularly useful for its scalability. In this article, PMF is extended to include scenarios that are commonly encountered in cyber-security applications. Specifically, an extension is proposed to explicitly handle binary adjacency matrices and include known categorical covariates associated with the graph nodes. A seasonal PMF model is also presented to handle seasonal networks. To allow the methods to scale to large graphs, variational methods are discussed for performing fast inference. The results show an improved performance over the standard PMF model and other statistical network models.
Quinolin-4(1H)-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria (2013)

We present a novel series of quinolin-4(1H)-imines as dual-stage antiplasmodials, several-fold more active than primaquine in vitro against Plasmodium berghei liver stage. Among those, compounds 5g and 5k presented low nanomolar IC50 values. The compounds are metabolically stable and modulate several drug targets. These results emphasize the value of quinolin-4(1H)-imines as a new chemotype and their suitable properties for further drug development.
In Situ Observation of Electromigration in Cu Film Using Scanning µ-Reflection High-Energy Electron Diffraction Microscope (1991)

We have observed void and hillock formation at the grain boundary and inside the grain in the Cu line due to electromigration (EM), by means of in situ nondestructive imaging of micrograins using a scanning µ-reflection high-energy electron diffraction (µ-RHEED) microscope. Accelerated electromigration testing was performed at a dc current density of 5×10 6 A/cm 2 and at 250°C in the scanning µ-RHEED microscope. The triple point of grain boundaries was confirmed to weaken the EM endurance. Furthermore, we conjectured that high EM endurance inside the grain could be achieved with the current flow along the &lt;011&gt; direction for fcc metal such as Cu.
Rivaroxaban — An Oral, Direct Factor Xa Inhibitor — Prevents Arterial Thrombotic Occlusion in Electrolytically Injured Rat Carotid Arteries. (2007)

Introduction: Rivaroxaban is an oral, direct Factor Xa (FXa) inhibitor in advanced clinical development for the prevention and treatment of thromboembolic disorders, including arterial indications such as acute coronary syndromes (ACS). The aim of this study was to determine whether rivaroxaban can prevent arterial thrombotic occlusion in electrolytically injured rat carotid arteries. Methods: Anesthetized, male Sprague-Dawley rats were equipped with an intravenous (i.v.) catheter to administer drug or vehicle and an intra-arterial catheter for arterial pressure monitoring and blood sampling. The left carotid artery was exposed and a bipolar electrode placed proximally around it. A pulsed Doppler flow probe was then placed distally around the vessel. Blood was obtained before drug or vehicle administration to determine activated clotting time (ACT), prothrombin time (PT), Russell’s viper venom time (RVVT), activated partial thromboplastin time (aPTT) and thrombin-antithrombin (TAT) complex concentration; baseline carotid blood flow was recorded for 20 minutes. Vehicle (polyethylene glycol:ethanol:water or saline, 0.5 mL/kg/min), rivaroxaban (0.3, 1 and 3 mg/kg; dosing volume 0.5 mL/kg/min), or the low molecular weight heparin enoxaparin (10 mg/kg) were infused i.v. over 30 seconds. After infusion, direct current (3 mA) was applied to the left carotid artery for 5 minutes. Blood flow was monitored for 30 minutes after injury. Blood was sampled again 14.5 and 30 minutes after injury for ACT determination, and after 30 minutes for PT, RVVT, TAT and aPTT determination. Results: Rivaroxaban dose-dependently increased the median time to arterial thrombotic occlusion (TTO), and was significantly more effective than vehicle at doses of 1 and 3 mg/kg (vehicle, 13.2 minutes; rivaroxaban 1 and 3 mg/kg, &gt;30 minutes; P&lt;0.05 by Kaplan-Meier analysis). Compared with enoxaparin (10 mg/kg), rivaroxaban inhibited TTO at doses of 1 and 3 mg/kg more effectively. Rivaroxaban (0.3–3 mg/kg i.v.) dose-dependently prolonged ACT, PT and RVVT, and substantially decreased the formation of TAT complexes, but did not substantially affect aPTT. Enoxaparin prolonged ACT, aPTT and RVVT, and decreased TAT complex formation, but had no effect on PT. Conclusions: Rivaroxaban potently inhibited electrolytically induced arterial thrombotic occlusion in rat carotid arteries, resulting in substantial changes in coagulation parameters. The coagulation parameter changes were consistent with inhibition of FXa activity as indexed by the RVVT. These findings suggest that rivaroxaban may be an effective anticoagulant in arterial thrombotic disorders, such as ACS.
GATA-6 stimulates a cell line-specific activation element in the human lactase promoter (1998)

Lactase-phlorizin hydrolase (LPH) synthesis is restricted to differentiated small intestinal enterocytes and is highly regulated during development. Analysis of expression of LPH promoter segments fused with luciferase transfected in Caco-2 cells, a line that uniquely expresses LPH mRNA, mapped an 18-base pair (bp) segment 100 bp upstream of the transcription start site that is required for transactivation. Remarkably, the LPH upstream element (LUE) has no stimulatory activity in both human intestinal and nonintestinal lines in which LPH mRNA is absent. Electrophoretic analysis of sequence-specific DNA-nuclear protein complexes demonstrated the presence of a Caco-2 cell-specific protein(s) (CCP), which is uniformly absent in LPH nonproducer cell lines. Mutational analysis of the LUE demonstrated that bases contained within a GATA consensus motif are critical for both CCP binding and transcription from the LPH promoter. Caco-2 cells express high levels of GATA-6 mRNA in a cell line-specific manner, suggesting that GATA-6 is a CCP that complexes with the LUE. When expressed by a plasmid, GATA-6 transactivated the LPH promoter. The stimulation was abrogated with mutations in the GATA consensus motif as well as mutations in a flanking downstream element. These studies are consistent with an important role of an intestinal GATA binding protein in cell type-specific transactivation of the LPH promoter.
Measurements of the parapapillary atrophy zones in en face optical coherence tomography images (2017)

En face images reconstructed from 3D SS-OCT data facilitated measurements of the beta and the gamma PPA zones even in eyes with optic disc distortion. The OCT-defined beta zone is associated with glaucoma and age, whereas the gamma zone correlated with myopia but not with glaucoma. This study confirmed the clinical usefulness of OCT-based classification of the PPA zones in distinguishing glaucomatous damage of the optic nerve from myopic damage in non-highly myopic eyes.
Visualization of the Internal Structure of Orientation-Patterned III–V Semiconductors (2015)

We investigate nonlinear diffraction in orientation-patterned semiconductors and identify Čerenkov second harmonic generation in a transverse geometry of interaction. Čerenkov second harmonic allows nondestructive 3D visualization of the internal structure of orientation-patterned semiconductor.
NANOSCOPIC STRAINING MECHANISMS IN INJECTION- MOULDED TPU MATERIALS AS REVEALED BY SAXS (2014)

Composites of thermoplastic polyurethane (TPU) (Elastollan ® 685A by BASF) and 0 to 0.5 wt-% 3-aminopropyltriethoxysilane functionalized silica spheres (diameter 14 nm) are strained and subjected to slow load-cycling 1 . The mechanical tests are monitored by small-angle X-ray scattering (SAXS). The fiber patterns from the injection-molded test bars are converted into chord distribution functions 2 (CDF) in real space for analysis of the nanostructure. It is found that the arrangement of the hard domains in the soft phase is poor. As the result, the scattering entities are very simple: There is only correlation between two hard-domains and the soft domain in between (“sandwich”). SAXS shows that the rubber-elastic extensibility of the soft phase is very limited. Macroscopic strain is accomplished by localized failure of single “springs” that relieve majority of the sandwiches. The nanostructure dissociates into broken and unbroken scattering entities. A broken entity is an elongated soft domain sandwiched between two fragments of hard domains. The nanoscopic strain of the sacrificed sandwich equals the macroscopic strain at the time of rupture. Initially with increasing strain the failure process propagates from regions with poorly arranged entities (PAE) regions that are invisible in the SAXS into the well-ordered ensembles (WAE) of hard domains. The more nanospheres are in the material, the earlier the dissociation arrives in the well-ordered fraction. Outbursts of local failure happen at strains of 100% and 200%. They relieve the global nanostructure considerably and the long period decreases. Very slow loadcycling of the pure TPU at low strain does not yet induce the failure mechanism. The material is elastic. In the nanocomposites (NC) the failure-induced dissociation starts already in the first cycle and increases during the application of cyclic load. Consequently, in the NCs the oscillation of the nanostructure decays from cycle to cycle whereas it stays constant with the pure TPU. The fraction of material that is not subjected to the decay is a function of the nanosphere content. Linear extrapolation yields a fraction of 1.25 wt.-% nanospheres at which the complete material would become homogeneous. Such a material would stop showing nanostructure oscillations after ca. 70 cycles. The relevance of these and other parameters for the prediction of mechanical properties in computer simulation is discussed. The SAXS patterns of relaxed samples are little different from that of the virgin materials, but the typical signature of the sandwich ensembles is much clearer their CDFs. The advantage of a CDF analysis with respect to a direct analysis is demonstrated and discussed.
Genetic Engineering of Glomerular Sclerosis in the Mouse via Control of Onset and Severity of Podocyte-Specific Injury (2005)

This study aimed to generate a mouse model of acquired glomerular sclerosis. A model system that allows induction of podocyte injury in a manner in which onset and severity can be controlled was designed. A transgenic mouse strain (NEP25) that expresses human CD25 selectively in podocytes was first generated. Injection of anti-Tac (Fv)-PE38 (LMB2), an immunotoxin with specific binding to human CD25, induced progressive nonselective proteinuria, ascites, and edema in NEP25 mice. Podocytes showed foot process effacement, vacuolar degeneration, detachment and downregulation of synaptopodin, WT-1, nephrin, and podocalyxin. Mesangial cells showed matrix expansion, increased collagen, mesangiolysis, and, later, sclerosis. Parietal epithelial cells showed vacuolar degeneration and proliferation, whereas endothelial cells were swollen. The severity of the glomerular injury was LMB2 dose dependent. With 1.25 ng/g body wt or more, NEP25 mice developed progressive glomerular damage and died within 2 wk. With 0.625 ng/g body wt of LMB2, NEP25 mice survived >4 wk and developed focal segmental glomerular sclerosis. Thus, the study has established a mouse model of acquired progressive glomerular sclerosis in which onset and severity can be preprogrammed by experimental maneuvers.
Superradiance in semiconductors (1999)

The dependences of the characteristic superradiance time in quantum well InGaAs/GaAs laser heterostructures on the pump current, temperature, and cross sections of the active region are studied by analyzing electroluminescence spectra. The number of dipoles involved in forming a superradiant pulse is estimated using elementary equations from the theory of superradiance in two-level systems. A mechanism is proposed for superradiance in semiconductors.
The Design of a New Ultrasonic Horn for Flip-Chip Bonding (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Effects of process conditions on the material characteristics of SIMOX with ITOX (2002)

High temperature oxidation of the low dose SIMOX has been shown to increase the thickness of the buried oxide, and improve its electrical characteristics in terms of pinhole densities, leakage current and breakdown voltage. The high temperature oxidation is a relatively new technique applied to low dose SIMOX and detailed characteristics of this material have not yet been finally explored. In our work on low dose SIMOX with internal thermal oxidation (ITOX), we observed the sensitivity of the characteristics of this material to the process conditions such as energy and dose of implanted oxygen, and temperature and ambient of the high temperature oxidation. Although the growth of the internal thermal oxide at the BOX interfaces, simultaneously accompanied by the oxidation of silicon inclusions in the BOX, was observed under wide range of process conditions, the leakage characteristics of the resultant buried oxide exhibited stronger dependencies on the process conditions than expected from the structural analysis. In this paper we continue to examine the effects of the process conditions on the structural and electrical characteristics of low dose SIMOX with ITOX.