gebhart/patrepeval huggingface dataset:
Tolerogenic bone marrow-derived dendritic cells induce neuroprotective regulatory T cells in a model of Parkinson’s disease (2018)

GM-CSF acts broadly to differentiate DCs and affect immune transformation from effector to regulatory immune responses. DCs skew such immune responses by increasing Treg numbers and activities that serve to attenuate proinflammatory responses and augment neuroprotection.
NITRIC OXIDE ACTIVATES THE CYCLOOXYGENASE PATHWAY IN INFLAMMATION (1995)

Salvemini, Daniela; Seibert, Karen; Masferrer, Jaime L.; Settle, Steven L.; Currie, Mark G.; Needleman, Philip Author Information
A miniature CSTR cascade for continuous flow of reactions containing solids (2016)

Continuous handling of solids creates challenges for realizing continuous production of pharmaceuticals and fine chemicals. We present a new miniature continuous stirred-tank reactor (CSTR) cascade to handle solid-forming reactions in flow. Single-phase residence time distribution (RTD) measurements of the CSTR cascade reveal nearly ideal CSTR mixing behavior of the individual units. Consistency of experimental and predicted conversions of a Diels–Alder reaction further confirms the CSTR performance. Two solid-forming reactions, (i) glyoxal reacting with cyclohexylamine to form N,N′-dicyclohexylethylenediimine, (ii) sulfonylation of 2-octanol with methanesulfonyl chloride, demonstrate the ability of the reactor cascade to transport solid particles continuously for hours without significant signs of clogging.
Structure of the retinal chromophore in the hRL intermediate of halorhodopsin from resonance Raman spectroscopy (1987)

Time-resolved resonance Raman spectra of the hRL intermediate of halorhodopsin have been obtained. The structurally sensitive fingerprint region of the hRL spectrum is very similar to that of bacteriorhodopsin's L550 intermediate, which is known to have a 13-cis configuration. This indicates that hRL contains a 13-cis chromophore and that an all-trans----13-cis isomerization occurs in the halorhodopsin photocycle. hRL exhibits a Schiff base stretching mode at 1644 cm-1, which shifts to 1620 cm-1 in D2O. This demonstrates that the Schiff base linkage to the protein is protonated. The insensitivity of the C-C stretching mode frequencies to N-deuteriation suggests that the Schiff base configuration is anti. The 24 cm-1 shift of the Schiff base mode in D2O indicates that the Schiff base proton in hRL has a stronger hydrogen-bonding interaction with the protein than does hR578.
Portal venous gas in a cardiac transplant patient. (1996)

Portal venous gas in a cardiac transplant patient.H T Ozgur, E C Unger and W H Wright, JrAudio Available | Share
Charge Neutralization Tunes Dynamic Arrest of Initially Disordered Reflectin Proteins (2020)

The intrinsically disordered reflectin proteins fill the reflective Bragg lamellae of iridescent cells in squid. In vivo, phosphorylation of the cationic reflectins leads to protein condensation and hierarchical assembly, driving osmotic dehydration of the lamellae and causing enhancement of intensity and tuning of the color of reflected light. In vitro, purified monomeric reflectin protein can be driven to cyclably and tunably assemble by pH‐neutralization or addition of salt, forming spheres of low polydispersity and reproducible size. Analysis of reflectin assembly by dynamic light scattering, x‐ray scattering, and transmission electron microscopy shows that the calibration between charge‐neutralization and assembly size is enabled by the rapid dynamic arrest of particle growth, as controlled by an electrostatic switch spatially distributed across the reflectin chain. Confocal microscopy of fluorescently labeled micron‐sized reflectin assemblies shows that they exhibit internal dynamics that rapidly slow following assembly, suggesting that assembly occurs through a transient liquid‐liquid phase separation that undergoes gelation to form stable protein‐dense condensates. Electron paramagnetic resonance (EPR) analysis shows the initially disordered reflectin monomers form ordered secondary structure that may be critical in the arrest of growth and stabilization of particles. These results provide new insights into the assembly of these unique intrinsically disordered proteins and the biophotonic systems they form, and suggest pathways for the creation of novel tunable biomaterials. Support or Funding Information This research was supported by the U.S. Department of Energy, U.S. Army Research Office, and Institute for Collaborative Biotechnologies.
Malaria epidemiology in an area of stable transmission in tribal population of Jharkhand, India (2017)

The collection of clinical data from a well-characterized tribal cohort from Jharkhand, India, has provided evidence for naturally acquired immunity against malaria in this hyperendemic region. The study also suggests that enforcement of existing control programmes can reduce the malaria burden further.
Organic polymeric coatings deposited by plasma enhanced chemical vapor deposition (2001)

A process of depositing thin organic polymeric coatings on electronic substrates by plasma enhanced chemical vapor deposition (PECVD) has been developed. We have designed halogenated compounds with PECVD reactive functionality attached to optically active moieties. Compounds have been screened selectively to lower the dielectric constant and enhance plasma polymerization efficiency. The chemical, optical, and mechanical properties of the deposited films such as film uniformity, film defectivity, film solubility, resist compatibility, conformality, adhesion to semiconductor substrates, refractive index, optical density, and photolithographic behavior have been studied. Plasma polymerized materials exhibit high sensitivity, excellent resolution, and good process latitude. PECVD provides a completely dry deposition process for wafer coating. The coatings possess high optical density at 193 nm.
Temporal pattern of stimulation modulates reflex bladder activation by pudendal nerve stimulation (2015)

These results reveal that the bladder response to pudendal afferent stimulation is dependent on the pattern, as well as the frequency, of stimulation. The computational model revealed that the effects of patterned pudendal afferent stimulation were determined by the dynamic properties of excitatory and inhibitory interneurons in the lumbosacral spinal cord. Neurourol. Urodynam. 35:882-887, 2016. © 2015 Wiley Periodicals, Inc.
ChemInform Abstract: Recent Advances in Lanthanide‐Containing Polyoxotungstates (2010)

Abstract Review: 42 refs.
Effect of helicopter transport on neurological outcomes in a mouse model of embolic stroke with reperfusion: AIR-MICE pilot study (2015)

This study shows that helicopter emergency medical services do not have an inherent adverse effect on outcome in a mouse model of ischemic stroke with reperfusion. These results endorse the safety of the practice of using helicopter emergency medical services in stroke patients. The observed potential synergistic effect of helicopter-induced factors, such as vibration and changes in altitude, with reperfusion merits further exploration in animal experimental models and in stroke patients.
Rigorous Simulation of Line-Defects in Extreme UV Masks (2005)

In this study, rigorous electromagnetic simulation is used to investigate the behavior of line defects in extreme UV (EUV) masks. Using the modal method by Fourier expansion (MMFE), the geometry of the structure as well as the polarization state can be handled. A simple analytical model has been developed in order to generate the input geometry for the simulations. The deposition conditions can be mimicked by changing an empirical parameter representing the planarization properties of the process. The influence of the defect size and of its position in the multilayer mirror is analyzed. The position of the defect with respect to an absorber feature is very important and is also considered. It is shown that the size of the nucleation particle by itself is not a relevant parameter to describe a defect. The process conditions greatly modify the propagation of the defect into the multilayer mirror and induce a very large variation in its printability. Some defects that do not affect the surface of the mirror can induce a nonnegligible intensity drop.
380 GS-3583, a novel FLT3 agonist Fc fusion protein, expands conventional dendritic cells in healthy volunteers (2021)

<h3>Background</h3> Conventional dendritic cells subtype 1 (cDC1) play a vital role in the priming and expansion of tumor specific CD8+ T cells and their recruitment to tumor microenvironment (TME). However, cDC1s are often underrepresented in the TME. Systemic administration of Fms-like tyrosine kinase 3 ligand (FLT3L), a hematopoietic growth factor that binds to FLT3 on myeloid and lymphoid progenitor cells, leads to expansion of cDC1s in the periphery which can then be recruited into the TME. FLT3 pathway stimulation using GS-3583, a novel FLT3 agonistic Fc fusion protein, has the potential to promote T cell mediated anti-tumor activity. We sought to evaluate the pharmacodynamic (PD) effect of a single dose of GS-3583 in healthy volunteers alongside its safety. Herein, we present the updated results of the study. <h3>Methods</h3> This was a first-in-human, placebo-controlled study of GS-3583 in healthy volunteers to evaluate the safety, pharmacokinetics (PK), and PD of escalating single doses (ranging from 75 micrograms to 2000 micrograms) of GS-3583. The study was blinded to the subjects and the investigator. Each dose cohort enrolled 8–12 healthy subjects who received GS-3583 or placebo as single IV infusion at 3:1 ratio. Subjects were observed in the phase 1 unit for 15 days and then for 12 weeks as outpatients. As part of the PD evaluation, we investigated the changes in the number of cDC1 and cDC2 cells. <h3>Results</h3> As of 2nd July 2021, selected safety, PK and PD data from all 4 cohorts were available. GS-3583 was well tolerated and all subjects had been discharged. To date, there have been no serious or grade 3 or higher adverse events. Preliminary PK analysis suggested dose-dependent increase in GS-3583 exposure (AUC and Cmax). Preliminary PD analysis shows that administration of GS-3583 resulted in temporary, dose-dependent increases in cDC1/cDC2 cells that peaked between days 5–11 (higher doses resulted in later peaks) and returned to baseline within 3 weeks of drug administration (table 1, figure 1). <h3>Conclusions</h3> GS-3583 infusion was well tolerated and induced dose dependent expansion of dendritic cells in the periphery in healthy volunteers. In patients with cancer, this increase in dendritic cells can be utilized to enhance anti-tumor therapeutic effects of immuno-oncology therapies. <h3>Acknowledgements</h3> Funding provided by Gilead Sciences, Inc. <h3>Ethics Approval</h3> The study received study site IRB/Ethics Committee approval prior to enrollment of subjects.
Synthesis and Characterization of Polyisobutylene-Polybutadiene Diblocks (1991)

Abstract The synthesis and characterization of novel polyisobutylene-poly-butadiene diblocks (PIB-b-PBd) are described. The total synthesis involves two steps: 1) The synthesis of t-chlorine terminated PIB (PIB-CH2C(CH3)2CI, PIB-CIt) and 2) the one-pot dehydrochlori-nation-metalation of PIB-CIt by n-BuLi/t-ROK system (where t-R = t-butyl, t-amyl) to the PIB‒CH2C(=CH2) CH- 2, (PIB-) anion followed by initiation of butadiene (Bd) polymerization by the macroanion. Detailed characterization studies including 13H- and 13C-NMR spectroscopies, GPC, fractional precipitation, and model compound studies conclusively prove the synthesis of the PIB-b-PBd diblocks with ∼ 60% 1,2 and ∼ 40% 1,4 PBd microstructure.
Quality Control of Electrolyte Analyzers: Evaluation of the Anion Gap Average (1984)

The authors have shown previously that averaging at least eight patient anion gaps provides a sensitive technic for the detection of systematic error in electrolyte analysis (Am J Clin Pathol 79:688-696, 1983). They conducted a retrospective and prospective evaluation of this technic on the ASTRA 4. One month of patient and control data were studied retrospectively and showed that 17/71 abnormally low patient anion gap averages were associated with violations in a multi-rule procedure, and 41/71 low averages were associated with violations in cusum, a more sensitive procedure. In the prospective study, a total of 36 runs of eight patient specimens with low anion gap averages (less than 7.5 mmol/L) were reanalyzed after appropriate recalibration and/or maintenance. Thirty-one of the 36 groups had significant changes in either Na (nine groups, delta Na = +1.5 mmol/L), Cl (14 groups; delta Cl = -1.8 mmol/L), or in both Na and Cl (eight groups; delta Na = +1.2 mmol/L; delta Cl = -0.9 mmol/L). Because the average error detected was small, the authors recommend that the average of anion gaps be used as an early indicator of drift. It must be used, however, in conjunction with standard quality control procedures such as the multi-rule approach.
Forecasting techniques for managing mobile data network capacity and growth (2012)

This paper proposes a two part methodology and modeling approach, covering techniques for managing mobile data network capacity and growth using Bell Labs forecasting and predictive techniques. The combined methodology overcomes the shortcomings of traditional forecasting techniques by using actual traffic data from the service provider's network and the service provider's “run-the-business” groups to obtain a detailed user behavior model. Subscriber forecast input from their marketing organization, along with the behavioral trends and Bell Labs forecasting algorithms, methodologies and tools allow for the generation of both baseline/short-term and predictive/longer-term forecasts.
Experimental Comparison of Nonlinear Compensation of Long-Haul PDM-QPSK Transmission at 42.7 and 85.4 Gb/s (2009)

We compare the nonlinear limits of 42.7 and 85.4 Gb/s PDM-QPSK transmission. Intra-channel nonlinearity compensation is demonstrated, with increase of optimum launch power by 1dB in each case and corresponding increase in maximum reach to 11635km and 8100km, respectively. © VDE VERLAG GMBH.
A new linear hybrid multiuser detector for CDMA systems (2005)

A new linear hybrid multiuser detection scheme is proposed. The structure cascades a linear successive interference cancellation detector and a linear parallel interference cancellation detector in order to extract the advantages of both. The convergence behavior of the hybrid scheme is investigated and moreover, the condition of convergence is determined. The proposed multiuser detector is compared to the other multiuser detectors in terms of complexity, delay, and other factors. Simulation results illustrate the superiority of the proposed.
Different profile of CD8+ effector T cells induced in Der p 1-allergic and na�ve mice by DNA vaccination (2002)

DNA vaccination holds great promise in both prophylactic and therapeutic vaccines. Recent evidence suggests that DNA vaccines could be powerful therapies countering Th2-mediated disorders such as allergies. Here, we studied the allergen-specific CD4+ and CD8+ T cell populations induced following immunization of allergic and non-allergic mice with DNA vaccine vectors encoding discrete epitopes of the house dust mite (HDM) Dermatophagoides pteronyssinus group I (Der p 1) allergen. Specifically, mice were sensitized to Der p 1 and exhibited a strong Th2/allergic response. Sensitized and non-allergic mice were then compared for their responses to DNA immunization. Using Elispot analysis, we demonstrate that allergic/vaccinated mice generate a mixed Th1/Th2 response against the allergen with high numbers of allergen-specific CD4+ T cells secreting IFN-gamma or IL-4, whereas in non-allergic/vaccinated mice a polarized Th1 response was dominant. Allergen-specific CD8+ T cells secreting IFN-gamma were induced at equal frequencies in both allergic and non-allergic mice. However, the CD8+ T cells from allergic mice were markedly deficient in their cytotoxic potential when compared to their counterparts in non-allergic mice. These results indicate that during an ongoing Th2 response, DNA vaccination leads to the generation of a distinct population of non-cytotoxic/regulatory CD8+ T cells.
The CMS experiment at the CERN LHC (2008)

TEST 02 - Elsevier's Scopus, the largest abstract and citation database of peer-reviewed literature. Search and access research from the science, technology, medicine, social sciences and arts and humanities fields.
Wafer level package for image sensor module (2008)

A new ISM (image sensor module) WLP (wafer level package) for reflow process is designed, fabricated and tested. The ISM WLP is composed of polymer bonding layer, glass cap wafer for particle free process and CIS (CMOS Image Sensor) chip wafer which has micro via hole interconnection. During the last decades, WLP is highlighted as the next generation ISM Package method for many advantages like high yield (particle free process), small form factor (3D interconnection), low assembly cost and so on. Nevertheless these benefits, there are some problems like micro via hole fabrication, low temperature insulation process (inside hole), bottom side oxide etching, warpage control according to wafer level bonding using different material, and whole process temperature limitation for micro lens damage. Among various fabrication methods for ISM package, COB (Chip on board), COF (Chip on film), and L, T contact WLP from ShellCase are generally used. In case of COB and COF package, it has difficulty in particle control during assembly process. In case of ShellCase type WLP has very complicated fabrication process. Additionally, most of above package has disadvantage in size point of view. Through suggested ISM WLP using through interconnection via, wafer level fabrication & packaging technology is realized. It can not only solve problems of conventional packaging structures but also tremendously reduce the manufacturing & assembly cost (include time) of ISM package and realize real chip scale package. Based on sensor size, 3.67 × 3.42 × 0.39 (H) mm3 WLP is designed. During the parametric study using commercial 3-D simulation programs, silicon thickness, polymer bonding layer thickness, and glass thickness were chose the effective factor. And considering the optical and electrical analysis, we decide the parameter: silicon thickness is 0.1mm, polymer bonding layer thickness is 0.04mm, and glass thickness is 0.25mm. The fabrication process is composed bonding layer patterning, wafer bonding, thinning, via etching, passivation layer deposition, bottom oxide opening, metal plating, bottom electrode patterning, solder ball formation, and dicing. A new concept of ISM WLP has been founded to be suitable structure for low cost, small form factor application.
From the Potent and Selective μ Opioid Receptor Agonist H-Dmt-d-Arg-Phe-Lys-NH2 to the Potent δ Antagonist H-Dmt-Tic-Phe-Lys(Z)-OH (2005)

H-Dmt-d-Arg-Phe-Lys-NH(2) ([Dmt(1)]DALDA) binds with high affinity and selectivity to the mu opioid receptor and is a potent and long-acting analgesic. Substitution of d-Arg in position 2 with Tic and masking of the lysine amine side chain by Z protection and of the C-terminal carboxylic function instead of the amide function transform a potent and selective mu agonist into a potent and selective delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH. Such a delta antagonist could be used as a pharmacological tool.
Low-Complexity PAPR Reduction Method for OFDM Systems Based on Real-Valued Neural Networks (2020)

High peak-to-average power ratio (PAPR) in orthogonal frequency division multiplexing (OFDM) systems is one of the major drawbacks in wireless transmitters. In this letter, a novel low complexity PAPR reduction method based on the real-valued neural network (NN) is proposed. This method first builds the PAPR reduction module using the real-valued NN to achieve the reduction of PAPR. To reconstruct the transmission signal, the PAPR decompression module is introduced into the receiving end to recover the signal in order to minimize the bit error rate (BER) of the systems. The PAPR reduction module and the PAPR decompression module can be jointly trained offline, therefore, the reduction of PAPR and the minimization of BER can be achieved simultaneously. To reduce the process rate of the PAPR reduction, the trained model uses multiple parallel processing links to achieve the reduction of the PAPR. The extensive simulations indicate that the proposed method outperforms previously available methods in terms of PAPR and BER, while having low complexity.
Front Matter: Volume 7402 (2009)

This PDF file contains the front matter associated with SPIE Proceedings Volume 7402, including the Title Page, Copyright information, Table of Contents, Introduction (if any), and the Conference Committee listing.
The Biophysical Response of Collagen-Fibrin Composite Gels to In Vitro Acupuncture (2010)

Therapeutic acupuncture involves the insertion and manipulation of fine needles at specific points. Although acupuncture has been proven effective for a number of conditions, the mechanisms that underlay these effects remain unknown. A critical first step is to identify the local changes that occur during needle manipulation, which can then be related to longer-term and more remote consequences. In vivo and ex vivo studies have demonstrated that loose collagenous subcutaneous connective tissue couples to needles during therapeutic manipulation, which deforms the tissue and exposes resident cells to altered mechanics and triggers morphologic and phenotypic changes. The resultant alignment of the tissue and cells may additionally help to propagate signals along acupuncture meridians.
StrassenNets: Deep Learning with a Multiplication Budget (2017)

A large fraction of the arithmetic operations required to evaluate deep neural networks (DNNs) consists of matrix multiplications, in both convolution and fully connected layers. We perform end-to-end learning of low-cost approximations of matrix multiplications in DNN layers by casting matrix multiplications as 2-layer sum-product networks (SPNs) (arithmetic circuits) and learning their (ternary) edge weights from data. The SPNs disentangle multiplication and addition operations and enable us to impose a budget on the number of multiplication operations. Combining our method with knowledge distillation and applying it to image classification DNNs (trained on ImageNet) and language modeling DNNs (using LSTMs), we obtain a first-of-a-kind reduction in number of multiplications (over 99.5%) while maintaining the predictive performance of the full-precision models. Finally, we demonstrate that the proposed framework is able to rediscover Strassen's matrix multiplication algorithm, learning to multiply $2 \times 2$ matrices using only 7 multiplications instead of 8.
Estimation of initial growth process of microcrystalline silicon thin film using double layered structure (2002)

Hydrogenated microcrystalline silicon (/spl mu/c-Si:H) films of single- and double-layered structures have been formed at different microwave powers and hydrogen dilution ratios on hydrogen-radical CVD method. The films have been analyzed using X-ray diffraction measurements (XRD), the E/sub 2/ peak intensity of ultraviolet reflectance and electrical conductivity. It was clarified that crystallinity of the upper growth layer is affected strongly by that of the lower initial layer and consequently it controls electrical conductivity. These results suggest that in continuous deposition of /spl mu/c-Si:H the same effects can be caused even if deposition conditions are changed during deposition.