gebhart/patrepeval huggingface dataset:
Early predictors of bladder recovery and urodynamics after spinal cord injury (1998)

Our purpose was to determine if intact perianal (S4-5) pin sensation (PPS) and bulbocavernosus (S2-4) reflex (BCR) shortly after spinal cord injury (SCI) are predictive of bladder function recovery. Twenty-eight SCI patients (aged 18-68 years, Frankel Classification A-D, spinal injury level C4-T12), admitted within 72 hours of injury, underwent evaluation of initial PPS and BCR. The presence of intact PPS and BCR were correlated with the patient's voiding function and urodynamic evaluation results 1 year postinjury. Of the 28 patients within 72 hours of SCI, PPS was intact in 17 (60%) and absent in 11(40%), while 15 patients (54%) demonstrated a positive BCR and 13 (46%) did not. One year after SCI, no patient with absent PPS voided unassisted, while of the 17 patients with preserved PPS, 11 (65%) were voiding spontaneously. Of these 11 patients, urodynamic evaluation revealed detrusor areflexia in 1 (9%), normal detrusor function in 2 (18%), and detrusor hyperreflexia in 8 (73%), with 3 of these 8 patients (38%) also demonstrating detrusor-sphincter dyssynergia. At 1 year postinjury, only 2 of 13 patients (15%) with an absent BCR voided spontaneously, while 9 of 15 patients (60%) with an intact BCR were able to void. Although PPS and BCR are moderately sensitive in predicting the return of spontaneous voiding, they cannot predict detrusor hyperreflexia and sphincter dyssynergia. Therefore, urodynamic study remains an essential component of initial urologic evaluation after SCI.
Instantaneous wave-free ratio guided multivessel revascularisation during percutaneous coronary intervention for acute myocardial infarction: study protocol of the randomised controlled iMODERN trial (2021)

NCT03298659.
Evaluation of In-Batch and In-Flow Synthetic Strategies towards the Stereoselective Synthesis of a Fluorinated Analogue of Retro-Thiorphan (2019)

A stereoselective synthetic strategy for the preparation of trifluoromethylamine mimics of retro-thiorphan, involving a diastereoselective, metal-free catalytic step, has been studied in batch and afforded the target molecule in good yields and high diastereoselectivity. A crucial point of the synthetic sequence was the catalytic reduction of a fluorinated enamine with trichlorosilane as reducing agent in the presence of a chiral Lewis base. The absolute configuration of the key intermediate was unambiguously assigned by X-ray analysis. The synthesis was also investigated exploiting continuous flow reactions; that is, an advanced intermediate of the target molecule was synthesized in only two in-flow synthetic modules, avoiding isolation and purifications of intermediates, leading to the isolation of the target chiral fluorinated amine in up to an 87:13 diastereoisomeric ratio.
Effects of Hydraulic Oils on Swash Plate Temperature of An Axial Piston Pump (2004)

Temperature of a swash plate of an axial piston pump was measured and seven kinds of hydraulic oils were assessed. Five thermo-couples were embedded in the swash plate and one thermistor was placed in the suction conduit of the pump. The test oils were mineral and synthetic type oils with the viscosity grade of 32 to 46, adding friction modifiers. The maximum discharge pressure was 20 MPa, discharge flow rate was 161/min, and the inlet oil temperature was 30℃. At the atmospheric to maximum discharge pressures, the temperatures, flow rates and the torque were measured, and then the swash plate temperature rises and the pump performance curve were obtained. In conclusion, i) A low viscous oil with the friction modifier gave a lower temperature rise; ii) As the discharge pressure increased, the temperature rises became larger, and iii) The types of the oils tested less influenced the performance curves.
Investigating the role of strangeness in baryon–antibaryon annihilation at the LHC (2022)

Annihilation dynamics plays a fundamental role in the baryon–antibaryon interaction (B–B‾) at low-energy and its strength and range are crucial in the assessment of possible baryonic bound states. Experimental data on annihilation cross sections are available for the p–p‾ system but not in the low relative momentum region. Data regarding the B–B‾ interaction with strange degrees of freedom are extremely scarce, hence the modeling of the annihilation contributions is mainly based on nucleon–antinucleon (N–N‾) results, when available. In this letter we present a measurement of the p–p‾, p–Λ‾⊕p‾–Λ and Λ–Λ‾ interaction using correlation functions in the relative momentum space in high-multiplicity triggered pp collisions at s=13 TeV recorded by ALICE at the LHC. In the p–p‾ system the couplings to the mesonic channels in different partial waves are extracted by adopting a coupled-channel approach with recent χEFT potentials. The inclusion of these inelastic channels provides good agreement with the data, showing a significant presence of the annihilation term down to zero momentum. Predictions obtained using the Lednický–Lyuboshits formula and scattering parameters obtained from heavy-ion collisions, hence mainly sensitive to elastic processes, are compared with the experimental p–Λ‾⊕p‾–Λ and Λ–Λ‾ correlations. The model describes the Λ–Λ‾ data and underestimates the p–Λ‾⊕p‾–Λ data in the region of momenta below 200 MeV/c. The observed deviation indicates a different contribution of annihilation channels to the two systems containing strange hadrons.
Combined node and span protection strategies with node-encircling p-cycles (2006)

We develop three new design models for combined node and span protection with a single set of node-encircling p-cycles (NEPCs). In a simple reference model each node is protected by a single dedicated NEPC. In the second model NEPCs can be shared by multiple nodes as needed, and each node is allowed to make use of as many different NEPCs as needed for a capacity-efficient design. To manage the complexity, protection routing is assumed to be evenly split in both directions around the NEPC, resulting in a slight over-provisioning of NEPCs and spare capacity. The final model is the most capacity efficient by virtue of also determining in which direction protection routing should proceed around each NEPC for each light-path affected by a node failure. The models can also permit a specified level of restorability below 100% so that a carrier could offer node-failure restorability on a differentiated service basis. A significant finding is that in test case networks 25% node restorability can be achieved in addition to 100% span restorability with a single integrated set of p-cycles that require as little as 4.1% more spare capacity than for conventional protection only against span-failures.
EFFICIENTSYNCHRONOUS TRANSMISSIONSUSINGSOFT-COMBINING FOR PAGING CHANNEL INOFDM BASED EVOLVED UTRA DOWNLINK (2006)

Thispaperproposes synchronous transmission withdelay diversity andsoft-combining reception inthesame NodeB forthepaging channel (PCH)andpaging indicator (PI) information intheOFDM based Evolved UTRAdownlink. Intheproposed transmission scheme, thePCH andPI information arereceived through soft-combining fromtwo contiguous sectors within thesameNodeB,toimprove the received signal-to-interference plusnoise powerratio (SINR) without mutual inter-sector interference. Computer simulation results showthat inathree-sectored cell, therequired number ofchannel symbols perinformation bitattheaverage packet error rate(PER)of10-2 using soft-combining reception witha sector-common pilot canbedecreased byapproximately 10- 20%compared tothat without soft-combining atthe5% outageprobability whentheinter-site distance is500 or1732m.Furthermore, inasix-sectored cell, theamountof therequired radio resources attheaverage PERof10-2 using soft-combining reception canbereduced byapproximately 30% compared tothecasewithout soft-combining. These results showtheeffectiveness oftheproposed methodfrom theviewpoint oftheincrease incoverage ofthePCH.
The dynamic model and hybrid phase-shift control of a dual-active-bridge converter (2008)

This paper presents an averaged model and a small-signal model of a bidirectional dual active bridge (DAB) DC-DC converter. Based on the proposed model, the stability and transient power flow in the system can be analyzed. A novel hybrid controller is proposed for the phase-shift based feed-back and feed-forward control of a 600V/10kW prototype. The hybrid controller can ease the difficulties of the parameter selection of a traditional PI. The effectiveness of the models and proposed hybrid controller are validated by simulations and experiments in both transient and steady state operations.
ChemInform Abstract: Efficient Methodology for the Preparation of β‐Aminotetralin Derivatives via Electrophilic Amination. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Effects of Combination Therapy With Glyburide and Insulin on Serum Lipid Levels in NIDDM Patients With Secondary Sulfonylurea Failure (1991)

Mean HbA1c decreased from 11.1% (range 9.8-12.9%) before insulin to 9.1% (range 6.8-11.4%) on day 325 (P less than 0.001) in IG patients and from 10.3% (range 8.4-13.3%) to 9.0% (range 6.3-11.8%) (P less than 0.05) in IP patients. In both groups, there was an increase in high-density lipoprotein cholesterol of approximately 20% lasting throughout the study (P less than 0.01). During the first 83 days of the study, there was a decrease in serum cholesterol (P less than 0.01) and serum triglycerides (P less than 0.05) in both groups. All changes in lipid variables were comparable in magnitude and duration in both treatment with insulin and glyburide in NIDDM patients with secondary sulfonylurea failure improves lipid metabolism to a similar degree as insulin therapy alone.
Characterisation of cytoplasmic DNA complementary to non-retroviral RNA viruses in human cells (2014)

The synthesis and subsequent genomic integration of DNA that is complementary to the genomes of non-retroviral RNA viruses are rarely observed. However, upon infection of various human cell lines and primary fibroblasts with the vesicular stomatitis virus (VSV), we detected DNA complementary to the VSV RNA. The VSV DNA was detected in the cytoplasm as single-stranded DNA fully complementary to the viral mRNA from the poly(A) region to the 7-methyl guanosine cap. The formation of this DNA was cell-dependent. Experimentally, we found that the transduction of cells that do not produce VSV DNA with the long interspersed nuclear element 1 and their infection with VSV could lead to the formation of VSV DNA. Viral DNA complementary to other RNA viruses was also detected in the respective infected human cells. Thus, the genetic information of the non-retroviral RNA virus genome can flow into the DNA of mammalian cells expressing LINE-1-like elements.
Non-lethal congenital hypotonia due to glycogen storage disease type IV (2006)

Glycogen storage disease type IV (GSD-IV) is an autosomal recessive genetic disorder due to a deficiency in the activity of the glycogen branching enzyme (GBE). A deficiency in GBE activity results in the accumulation of glycogen with fewer branching points and long, unbranched outer chains. The disorder results in a variable phenotype, including musculoskeletal, cardiac, neurological, and hepatic involvement, alone or in continuum, which can be identified at any stage of life. The classic form of GSD-IV is a hepatic presentation, which presents in the first 18 months of life with failure to thrive, hepatomegaly, and cirrhosis that progresses to liver failure, resulting in death by age 5 years. A severe congenital musculoskeletal phenotype with death in the neonatal period has also been described. We report an unusual case of congenital musculoskeletal presentation of GSD-IV with stable congenital hypotonia, gross motor delay, and severe fibro-fatty replacement of the musculature, but no hepatic or cardiac involvement. Molecular analysis revealed two novel missense mutations with amino acid changes in the GBE gene (Q236H and R262C), which may account for the mild phenotype.
Is There Chronic Brain Damage in Retired NFL Players? Neuroradiology, Neuropsychology and Neurology of 45 Retired Players (P5.325) (2014)

OBJECTIVE: To determine the objective clinical, neuropsychological and neuroradiological status of a convenience sample of living, 30-60 year old retired NFL players. BACKGROUND: Neuropathology and surveys of retired NFL players suggest that chronic brain damage is a frequent result of a career in football. There is limited information on the neurological status of living retired players. DESIGN/METHODS: A day-long in-depth medical examination was conducted on 45 retired NFL players, including state-of-the-art MRI (SWI, DTI), comprehensive neuropsychological and neurological examinations, interviews, blood tests and APOE genotyping. The results were statistically analyzed for associations with markers of exposure to football and related factors, such as BMI, ethanol use, APOE4 status. RESULTS: The retired players were 45.6 ± 8.9 years old (range 30-60 years) and had 6.8 ± 3.2 years (up to 14 years) of NFL play. They reported 6.9 ± 6.2 concussions (up to 25) in the NFL. The majority of retired players had normal clinical mental status and CNS neurological examinations. Four players (9%) had microbleeds in brain parenchyma and three (7%) had a large cavum septum pellucidum. The number of concussions/dings was associated with abnormal results in SWI and DTI. Neuropsychological (NP) testing revealed isolated impairments in 11 players (24%) but none had dementia. Nine players (20%) endorsed symptoms of moderate or severe depression. None had dementia, dysarthria, parkinsonism or cerebellar dysfunction. The APOE 4 allele was present in 38% of the players, a larger number than would be expected in the general male population (23%-26%). CONCLUSIONS: MRI lesions and NP impairments were found in some players; however, the majority of retired NFL players had no clinical signs of chronic brain damage. These results need to be reconciled with the prevailing view that a career in football frequently results in chronic brain damage. Study Supported by: The data collection portion of this study was funded by the NFL.
SUPPLEMENTAL MATERIALS from Results from an Integrated Safety Analysis of Urelumab, an Agonist Anti-CD137 Monoclonal Antibody (2023)

&lt;p&gt;Methods Supplement Supplementary Table 1. Patients Included in E-R Analysis Supplementary Table 2. Patients From Studies -006 and -011 Not Included in ER Analysis Supplementary Fig 1. Serum concentration:time profile of urelumab across the dose range evaluated (0.1 to 15 mg/kg) Supplementary Fig 2. Induction of a range of IFN-response genes by urelumab 0.1 mg/kg&lt;/p&gt;
Evaluating feature selection strategies for high dimensional, small sample size datasets (2011)

In this work, we analyze and evaluate different strategies for comparing Feature Selection (FS) schemes on High Dimensional (HD) biomedical datasets (e.g. gene and protein expression studies) with a small sample size (SSS). Additionally, we define a new feature, Robustness, specifically for comparing the ability of an FS scheme to be invariant to changes in its training data. While classifier accuracy has been the de facto method for evaluating FS schemes, on account of the curse of dimensionality problem, it might not always be the appropriate measure for HD/SSS datasets. SSS lends the dataset a higher probability of containing data that is not representative of the true distribution of the whole population. However, an ideal FS scheme must be robust enough to produce the same results each time there are changes to the training data. In this study, we employed the robustness performance measure in conjunction with classifier accuracy (measured via the K-Nearest Neighbor and Random Forest classifiers) to quantitatively compare five different FS schemes (T-test, F-test, Kolmogorov-Smirnov Test, Wilks Lambda Test and Wilcoxon Rand Sum Test) on 5 HD/SSS gene and protein expression datasets corresponding to ovarian cancer, lung cancer, bone lesions, celiac disease, and coronary heart disease. Of the five FS schemes compared, the Wilcoxon Rand Sum Test was found to outperform other FS schemes in terms of classification accuracy and robustness. Our results suggest that both classifier accuracy and robustness should be considered when deciding on the appropriate FS scheme for HD/SSS datasets.
ChemInform Abstract: A Palladium Catalyzed Route to a Benzofuran Analogue of Indolactam V ( ILV): Effects on PKC Isotype Selectivity. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A new target region for changing the substrate specificity of amine transaminases (2015)

(R)-stereospecific amine transaminases (R-ATAs) are important biocatalysts for the production of (R)-amine compounds in a strict stereospecific manner. An improved R-ATA, ATA-117-Rd11, was successfully engineered for the manufacture of sitagliptin, a widely used therapeutic agent for type-2 diabetes. The effects of the individual mutations, however, have not yet been demonstrated due to the lack of experimentally determined structural information. Here we describe three crystal structures of the first isolated R-ATA, its G136F mutant and engineered ATA-117-Rd11, which indicated that the mutation introduced into the 136(th) residue altered the conformation of a loop next to the active site, resulting in a substrate-binding site with drastically modified volume, shape, and surface properties, to accommodate the large pro-sitagliptin ketone. Our findings provide a detailed explanation of the previously reported molecular engineering of ATA-117-Rd11 and propose that the loop near the active site is a new target for the rational design to change the substrate specificity of ATAs.
Anti-Müllerian Hormone Signaling Regulates Epithelial Plasticity and Chemoresistance in Lung Cancer (2016)

Anti-Müllerian hormone (AMH) and its type II receptor AMHR2, both previously thought to primarily function in gonadal tissue, were unexpectedly identified as potent regulators of transforming growth factor (TGF-β)/bone morphogenetic protein (BMP) signaling and epithelial-mesenchymal transition (EMT) in lung cancer. AMH is a TGF-β/BMP superfamily member, and AMHR2 heterodimerizes with type I receptors (ALK2, ALK3) also used by the type II receptor for BMP (BMPR2). AMH signaling regulates expression of BMPR2, ALK2, and ALK3, supports protein kinase B-nuclear factor κB (AKT-NF-κB) and SMAD survival signaling, and influences BMP-dependent signaling in non-small cell lung cancer (NSCLC). AMH and AMHR2 are selectively expressed in epithelial versus mesenchymal cells, and loss of AMH/AMHR2 induces EMT. Independent induction of EMT reduces expression of AMH and AMHR2. Importantly, EMT associated with depletion of AMH or AMHR2 results in chemoresistance but sensitizes cells to the heat shock protein 90 (HSP90) inhibitor ganetespib. Recognition of this AMH/AMHR2 axis helps to further elucidate TGF-β/BMP resistance-associated signaling and suggests new strategies for therapeutic targeting of EMT.
Design, fabrication and testing of a production line for TPX demonstration conductor (1997)

A complete production line for fabricating CICC dummy conductor has been designed, constructed and tested for TPX program. The line is capable of producing up to 500 meters of CICC conductor and is scaleable up to 1.5 km in length. The line consists of a payoff spool for feeding cable inside the tubes, a welding station, a drawing station which includes dies and a bull-block, and a takeup spool. We have demonstrated the fabrication of the conductors. Two types of conductor, one for TF and the other one for PF coil have been produced The conduit materials are Incoloy 908, which are formed from strips. The cables are made from OFHC copper strands. The detail design, fabrication and testing of each component of the system is presented in this paper.
Tree-structured residual vector quantisationwith constrained storage for image coding (1994)

A tree-structured residual vector quantisation (VQ) algorithm with constrained storage based on a codebook sharing algorithm is proposed. The algorithm provides an intermediate property of multistage VQ and tree-structured VQ, and thereby can trade off coding performance for storage requirement. The algorithm is especially suited to image coding where a large vector dimension is preferred due to its coding efficiency.
Quantum dots in photonic crystal cavities (2012)

During the past two decades, the development of micro- and nano-fabrication technologies has positively impacted multiple areas of science and engineering. In the photonics community, these technologies had numerous early adopters, which led to photonic devices that exhibit features at the nano-scale and operate at the most fundamental level of light–matter interaction [28, 39, 18, 29]. One of the leading platforms for these types of devices is based on gallium arsenide (GaAs) planar photonic crystals (PC) with embedded indium arsenide (InAs) quantum dots (QDs). The PC architecture is advantageous because it enables monolithic fabrication of photonic networks for efficient routing of light signals of the chip [26]. At the same time, PC devices have low loss and ultra-small optical mode volumes, which enable strong light–matter interactions. The InAs quantum dots are well suited for quantum photonic applications because they have excellent quantum efficiencies, large dipole moments, and a variety of quantum states that can be optically controlled [24, 3].
Prostasin regulates PD-L1 expression in human lung cancer cells (2021)

The serine protease prostasin is a negative regulator of lipopolysaccharide-induced inflammation and has a role in the regulation of cellular immunity. Prostasin expression in cancer cells inhibits migration and metastasis, and reduces epithelial-mesenchymal transition. Programmed death-ligand 1 (PD-L1) is a negative regulator of the immune response and its expression in cancer cells interferes with immune surveillance. The aim of this study was to investigate if prostasin regulates PD-L1 expression. We established sublines over-expressing various forms of prostasin as well as a subline deficient for the prostasin gene from the Calu-3 human lung cancer cells. We report here that PD-L1 expression induced by interferon-gamma (IFNg) is further enhanced in cells over-expressing the wild-type membrane-anchored prostasin. The PD-L1 protein was localized on the cell surface and released into the culture medium in extracellular vesicles (EVs) with the protease-active prostasin. The epidermal growth factor-epidermal growth factor receptor (EGF-EGFR), protein kinase C (PKC), and mitogen-activated protein kinase (MAPK) participated in the prostasin-mediated up-regulation of PD-L1 expression. A Gene Set Enrichment Analysis (GSEA) of patient lung tumors in The Cancer Genome Atlas (TCGA) database revealed that prostasin and PD-L1 regulate common signaling pathways during tumorigenesis and tumor progression.