gebhart/patrepeval huggingface dataset:
Controlled cooling of an electronic system for reduced energy consumption (2023)

Energy efficient control of a cooling system cooling an electronic system is provided. The control includes automatically determining at least one adjusted control setting for at least one adjustable cooling component of a cooling system cooling the electronic system. The automatically determining is based, at least in part, on power being consumed by the cooling system and temperature of a heat sink to which heat extracted by the cooling system is rejected. The automatically determining operates to reduce power consumption of the cooling system and/or the electronic system while ensuring that at least one targeted temperature associated with the cooling system or the electronic system is within a desired range. The automatically determining may be based, at least in part, on one or more experimentally obtained models relating the targeted temperature and power consumption of the one or more adjustable cooling components of the cooling system.
ChemInform Abstract: A Highly Convergent Strategy for the Synthesis of 4‐Demethoxydaunomycinone and Daunomycinone: A Novel Synthesis of C4‐Acetoxylated Homophthalic Anhydrides. (1986)

Abstract Aus dem Homophthalsäureester (Ia) erhält man über das Ketenacetal (II) mit Persäure den Diester (III) und weiter die PhthaIid‐carbonsäure (IV).
Cardiac anatomy as a biometric (2012)

In this study, we propose a novel biometric signature for human identification based on anatomically unique structures of the left ventricle of the heart. An algorithm is developed that analyzes the 3 primary anatomical structures of the left ventricle: the endocardium, myocardium, and papillary muscles. Comparisons of these analyses between probe and gallery images produces a similarity score that is used as the basis of the biometric. The performance of the algorithm is tested on a cohort of 10 de-identified subjects imaged by Cardiac MRI. Perfect matching between individuals is obtained with good separation between the genuine and impostor classes. In summary, this study demonstrates using anatomy of the left ventricle of the human heart for the purposes of a biometric signature.
1505 Local High Resolution MRI with a Micro Planar Coil (2008)

This paper reports on a micro planar coil as a receiver for a high resolution MRI (Magnetic Resonance Imaging). In this study, a micro planar coil of 10 mm in diameter was fabricated. The MRI signal receiving device was made by attaching the micro coils to the tip of acrylic pipes. The signal to noise ratio of MR image taken by the micro planar coil was 8 times as high as MR image taken by medical MRI coil. MR images of okra (Abelmoschus esculentus) were acquired with 2.0×2.0×2.0 mm^3 and 0.5×0.5×1.0 mm^3 resolutions.
Non-invasive imaging of freshly excised parathyroid glands using confocal reflectance microscopy (2000)

Abstract Background Successful surgical management of primary hyperparathyroidism requires an understanding of the underlying pathological diagnosis. Various methods have been employed to distinguish normal from hyperfunctional diseased glands. Confocal reflectance microscopy (CRM) is a novel optical method of imaging tissue non-invasively without the need for fixation, sectioning and staining as in standard histopathology. Gray-scale images are displayed in real time on a monitor, and represent horizontal (en face) optical sections through the tissue. Using CRM, the goal of this study was to delineate histological features characteristic of the parathyroid gland, and to determine if confocal imaging could distinguish normal from adenomatous parathyroid tissue. Methods In this pilot observational cohort study, a total of 18 parathyroid glands was imaged using CRM immediately after excision in eight patients undergoing surgery for primary hyperparathyroidism. Confocal images were compared with corresponding permanent, haematoxylin and eosin-stained sections obtained from the same gland. For each patient, the percentage area occupied by fat cells was calculated in ten independent images (593 μm × 509 μm) of both normal and diseased glands. Results Characteristic histological features of the parathyroid gland were readily discernible by CRM and correlated well with permanent, haematoxylin and eosin-stained sections. The fat content of both normal and diseased glands could be determined easily. The percentage area occupied by fat cells was distinctly different in normal (mean(s.d.) 21·8(5·3) per cent) and diseased (0·9(2·4) per cent) parathyroid glands. Conclusion CRM rapidly revealed histological features of the parathyroid gland without histological processing. This new, simple, rapid and non-invasive technique has the potential for use as an adjunct to frozen-section analysis in intraoperative consultation during parathyroidectomy. This may provide a technique for in situ histological diagnosis of endocrine or other tissues without an excisional biopsy. Work is currently under way to develop an intraoperative probe for in vivo use.
Studies on the induction of the interleukin-6 promoter in cell lines of human and simian origin. (1994)

In a number of eukaryotic cell types, the promoter of the interleukin-6 (IL-6) gene is inducible by several agents. We studied this inducibility in two human (MG63 and HeLa H21) and four simian cell lines (BSC-1, AP8, CV-1 and VERO). Furthermore, we also investigated whether this inducibility was maintained when a heterologous gene was placed under control of the human IL-6 promoter. As a heterologous gene we used the Simian Virus 40 (SV40) large T antigen, because of its stimulatory effects on SV40-based expression vectors. For the human cell lines tested, we observed that this gene was equally well induced and controlled as the endogenous IL-6 gene. In contrast, the aforementioned simian cell lines were only slightly inducible for IL-6 production; moreover, after transfection with the IL-6 promoter--SV40 T antigen gene construct, a continuous, low level of expression was found, even in those lines which only showed a low (CV-1) or no (BSC-1) endogenous IL-6 background. This apparent difference between the human and simian cells analyzed does not reflect a species specificity, but presumably is related to a different differentiation state of these cells. Furthermore, the IL-6 gene induction could be correlated with activation of the required transcription factor NF-kappa B.
Nucleoticle sequences of cDNAs α and γ enolase mRNAs from mouse brain (1990)

Journal Article Nucleoticle sequences of cDNAs α and γ enolase mRNAs from mouse brain Get access Mourad Kaghad, Mourad Kaghad Search for other works by this author on: Oxford Academic PubMed Google Scholar Xavier Dumont, Xavier Dumont Search for other works by this author on: Oxford Academic PubMed Google Scholar Pascale Chalon, Pascale Chalon Search for other works by this author on: Oxford Academic PubMed Google Scholar Jean-Michel Lelias, Jean-Michel Lelias Search for other works by this author on: Oxford Academic PubMed Google Scholar Noël Lamandé, Noël Lamandé 1Laboratoire de Biochimie Cellulaire, Collège de France11 Place Marcelin Berthelot, 75005 Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Marguerite Lucas, Marguerite Lucas 1Laboratoire de Biochimie Cellulaire, Collège de France11 Place Marcelin Berthelot, 75005 Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Monique Lazar, Monique Lazar 1Laboratoire de Biochimie Cellulaire, Collège de France11 Place Marcelin Berthelot, 75005 Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Daniel Caput Daniel Caput Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 18, Issue 12, 25 June 1990, Page 3638, https://doi.org/10.1093/nar/18.12.3638 Published: 25 June 1990 Article history Received: 21 May 1990 Published: 25 June 1990
Engine Architecture for High Efficiency at Small Core Size (2016)

This technical article discusses architectural design and requirements for high-efficiency engines. Advanced fuel-efficient commercial aircrafts for entry into service in 2035 have quite different configurations than current transports, requiring new architectures for their jet engines. The alternative engine architecture potentially enables a high-overall pressure ratio all-axial compression system at small core size, while maintaining high compressor and turbine efficiencies. The concept engine also makes use of the reverse angled core to address the FAA 1-in-20 rule. It is noted that the reverse angled core engine concept architecture is only feasible at ultra-high bypass ration such that the core engine can be packaged within ducting positioned crosswise to the fan exit flow. Future studies would consider 3D design of the high turning ducts and compressor design technology for reduced exit Mach number to further increase exit annulus height and reduce sensitivity to tip clearances.
Novel Laboratory Cell for Fundamental Studies of the Effect of Polymer Additives on Wax Deposition from Model Crude Oils (2007)

An in-depth understanding of the effects of polymer additives upon the rate, composition, and structure of paraffin deposition is required in the development of deep, off-shore oil fields to predict treatment strategies. To this end, we have developed a new laboratory-scale deposition cell that enables the measurement of wax deposition under controlled shear stresses and thermal gradients. A model oil with 3 wt % of a multicomponent wax was tested in a parallel-plate laboratory-scale deposition cell under laminar flow at low and high wall shear stress conditions (5−7 and 60−90 Pa, respectively). The addition of 0.1 wt % of poly(ethylene butene) (PEB), which has been shown to reduce the yield stress of the gelled solution 10-fold, actually increased the initial deposition rate. However, the deposit eroded from the surface under low shear stress conditions, while the deposit remained intact under high shear stress conditions. The addition of poly(maleic anhydride octadecene) modified with octadecyl amine and poly(maleic anhydride ethyl vinyl ether) modified with docosanyl amine each prevented deposition under similar conditions. Results provide a consistent framework for understanding the role of polymer additives on deposition in terms of the temperature field above the deposition surface and the cloud point of the solution. Polymers that suppress wax nucleation and suppress the cloud point will prevent deposition if the surface temperature is above the cloud point. This is the case with poly(maleic anhydride octadecene) modified with octadecyl amine polymers. Polymers that prevent wax crystal aggregation by a colloidal stabilization mechanism but that do not suppress nucleation do not prevent deposition. PEB polymers fall in this class. However, these polymers can produce deposited layers with sufficiently low mechanical strength that layer thickness can be controlled by erosion. The mechanism of erosion is demonstrated for the maleic anhydride copolymer. Results from gas chromatography and optical microscopy examine the composition and structure of the deposits.
Dendritic effects in catalysis by Pd complexes of bidentate phosphines on a dendronized support: Heck vs. carbonylation reactions (2008)

Bidentate phosphine ligands have been prepared on polystyrene beads modified with polyether dendron spacers. When complexed to Pd(0), these systems exhibited a negative dendritic effect on Heck catalysis (contrary to the analogous monodentate phosphine systems), but mostly a positive influence on carbonylation. This opposite influence of the dendronization falls into line with other differences in the optimal ligand structure for the two reactions. The negative effect on the Heck catalysis with bidentate phosphines may indicate that dendrimer-induced reduction in the cross-linking upon Pd complexation is responsible for the positive effect in the corresponding monodentate phosphine systems.
Effects of Discrete Lesions of Preoptic and Suprachiasmatic Structures in the Female Rat (1980)

The purpose of this study was to determine which specific structures within the medial preoptic-anterior hypothalamic area are necessary to maintain cyclic ovulation in the rat, and to define the deifcit(s) in the feedback regulation of gonadotropin secretion associated with lesions that result in anovulation. Large (approximately 1.1 mm dia.) or small (approximately 0.7 mm dia.) electrolytic lesions were placed in several loci within preoptic, anterior hyopthalamic and suprachiasmatic areas in regularly cycling adult female rats. Large lesions which included the suprachiasmatic nuclei (SCN) induced an anovulatory condition characterized by persistent vaginal cornification and polyfollicular ovaries (persistent estrus). Large or small lesions which included the medial preoptic nucleus (MPN), a small periventricular column of cells located immediately caudal to the organum vasculosum of the lamina terminalis (OVLT), also induced persistent estrus. Lesions placed elsewhere within the medial preoptic-anterior hypothalamic area never induced persistent estrus but were frequently associated with repeated periods of prolonged diestrus separated by brief periods of vaginal cornification. These prolonged diestrous intervals appeared to be related to spontaneous luteal activation following ovulation rather than impaired folliculogenesis. LH and FSH surges induced by sequential administration of estradiol benzoate and progesterone (P) were completely abolished only by lesions which included the MPN. Small lesions involving only the MPN and OVLT or the MPN and caudally adjacent loci in the suprachiasmatic region were as effective in this respect as larger lesions encompassing most of the preoptic-suprachiasmatic region from the diagonal band of Broca to the rostral pole of the SCN. On the other hand, P-induced gonadotropin surges were never completely blocked by SCN lesions, although the magnitude of the surge was highly variable and frequently attenuated compared to controls. It is concluded that both the MPN and SCN are required for the long-term maintenance of spontaneous cyclic ovulation in the rat. However, the characteristically dissimilar deficits in P-induced gonadotropin release associated with lesions of one or the other of these structures indicate that these nuclei may play different roles in the regulation of gonadotropin surges. It is suggested that neural elements indispensable for phasic gonadotropin release are located within and/or immediately adjacent to the MPN. The SCN may influence phasic gonadotropin release indirectly, by regulating circadian rhythms which govern the responsiveness of other neural elements to hormonal stimuli.
QUBIC4plus: a cost-effective BiCMOS manufacturing technology with elite passive enhancements optimized for 'silicon-based' RF-system-in-package environment (2005)

QUBiC4plus is a RF-BiCMOS production technology tailored for 'silicon-based' RF-SiP. The device menu includes 3 varactor styles, 7 resistor types, novel complimentary 24 V PMU devices, hi-k MIM capacitors, RC-triggered ESD protection and a choice between all-silicon, SiGe and SiGe:C bipolar transistors. Buried-p+ guardrings, DTI and very-high resistivity substrates ensure excellent circuit-block isolation and high-quality inductors. The advanced design flow features state-of-the-art models.
Quantum Dots Encapsulated with Curcumin Inhibit The Growth of Colon Cancer, Breast Cancer and Bacterial Cells (2020)

<b>Aim:</b> To synthesize and examine the impact of free Eudragit<sup>®</sup> RS 100 nanoparticles (LN01), Quantum dots curcumin-loaded Eudragit RS 100 nanoparticles (LN04), and un-encapsulated curcumin nanoparticles (LN06) on cancerous and bacterial cells. <b>Materials & methods:</b> The LN01, LN04, LN06 were synthesized and characterized by Fourier transform infrared, ζ potential, UV-Vis spectroscopy, transmission electron microscopy and scanning electron microscopy and their biological activities were evaluated. <b>Results:</b> LN04 profoundly inhibited the growth of colon (HCT-116) cancerous cells (10.64% cell viability) and breast cancer (MCF-7) cells (10.32% cell viability) with compared to LN01 and LN06. Normal cells (HEK-293) did not show any inhibition after treatments. In addition, LN04 show better inhibitory action on bacterial growth compared with LN01 and LN06. <b>Conclusion:</b> We suggest that LN04 selectively target cancerous and bacterial cells and therefore possess potential anticancer and antibacterial capabilities.
Synthesis and properties of polymeric azine and thiazine dyes (1978)

Abstract Some polymeric azine or thiazine dyes were prepared by radical polymerization of dye monomers or by polymer reactions between dyes and suitable prepolymers, and their photoredox reactivities were studied. The thionine polymers containing labile OH groups exhibited photochromism and thermochromism, which were extremely sensitive to the moisture content of the polymer film. The reversibility of the photochromism and thermochromism increased with the water content in the film. The water‐soluble polymeric dyes were photobleached under the influence of suitable reducing agents. The degree of photobleaching was smaller than for the monomeric systems except for the dye polymers containing OH groups, probably because of the large steric hindrance of the polymers.
Different design of enzyme-triggered CO-releasing molecules (ET-CORMs) reveals quantitative differences in biological activities in terms of toxicity and inflammation (2014)

Acyloxydiene-Fe(CO)3 complexes can act as enzyme-triggered CO-releasing molecules (ET-CORMs). Their biological activity strongly depends on the mother compound from which they are derived, i.e. cyclohexenone or cyclohexanedione, and on the position of the ester functionality they harbour. The present study addresses if the latter characteristic affects CO release, if cytotoxicity of ET-CORMs is mediated through iron release or inhibition of cell respiration and to what extent cyclohexenone and cyclohexanedione derived ET-CORMs differ in their ability to counteract TNF-α mediated inflammation. Irrespective of the formulation (DMSO or cyclodextrin), toxicity in HUVEC was significantly higher for ET-CORMs bearing the ester functionality at the outer (rac-4), as compared to the inner (rac-1) position of the cyclohexenone moiety. This was paralleled by an increased CO release from the former ET-CORM. Toxicity was not mediated via iron as EC50 values for rac-4 were significantly lower than for FeCl2 or FeCl3 and were not influenced by iron chelation. ATP depletion preceded toxicity suggesting impaired cell respiration as putative cause for cell death. In long-term HUVEC cultures inhibition of VCAM-1 expression by rac-1 waned in time, while for the cyclohexanedione derived rac-8 inhibition seems to increase. NFκB was inhibited by both rac-1 and rac-8 independent of IκBα degradation. Both ET-CORMs activated Nrf-2 and consequently induced the expression of HO-1. This study further provides a rational framework for designing acyloxydiene-Fe(CO)3 complexes as ET-CORMs with differential CO release and biological activities. We also provide a better understanding of how these complexes affect cell-biology in mechanistic terms.
Differential effects of a soluble or immobilized VEGFR-binding peptide (2012)

Regulating endothelial cell behavior is a key step in understanding and controlling neovascularization for both pro-angiogenic and anti-angiogenic therapeutic strategies. Here, we characterized the effects of a covalently immobilized peptide mimic of vascular endothelial growth factor, herein referred to as VEGF receptor-binding peptide (VR-BP), on human umbilical vein endothelial cell (HUVEC) behavior. Self-assembled monolayer arrays presenting varied densities of covalently immobilized VR-BP and varied densities of the fibronectin-derived cell adhesion peptide Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) were used to probe for changes in HUVEC attachment, proliferation and tubulogenesis. In a soluble form, VR-BP exhibited pro-angiogenic effects in agreement with previous studies, indicated by increases in HUVEC proliferation. However, when presented to cells in an insoluble context, covalently immobilized VR-BP inhibited several pro-angiogenic HUVEC behaviors, including attachment and proliferation, and also inhibited HUVEC response to soluble recombinant VEGF protein. Furthermore, substrates with covalently immobilized VR-BP also modulated HUVEC tubulogenesis when a matrigel overlay assay was used to provide cells with a pseudo-three dimensional environment. Taken together, these results demonstrate that the context in which ligands are presented to cell surface receptors strongly influences their effects, and that the same ligand can be an agonist or an antagonist depending on the manner of presentation to the cell.
Arm-current-based control of modular multilevel converters (2013)

Inner control of a Modular Multilevel Converter (M2C) based on direct tolerance-band modulation of the arm currents has been studied. This approach is attractive because it allows low switching frequency, directly provides the desired arm-current waveform and enables fast protective actions at the same time as the complexity of the over-all control system is reduced. Issues related to common-mode voltage are discussed and supporting PSCAD simulations are presented together with some results from experiments with a reduced-power prototype converter.
Bag‐1 and Bcl‐2 Gene Transfer in Malignant Glioma: Modulation of Cell Cycle Regulation and Apoptosis (2000)

Bag-1 is a heat shock 70 kDa (Hsp70)-binding protein that can collaborate with Bcl-2 in suppressing apoptosis under some conditions. Here, we report that 11 of 12 human glioma cell lines express Bag-1 protein in vitro. Moreover, 15 of 19 human glioblastomas expressed Bag-1 as assessed by immunohistochemistry in primary tumor specimens. To examine the biological effects of Bag-1 in glioma cells, we expressed Bag-1 or Bcl-2 transgenes in 2 human malignant glioma cell lines, LN-18 and LN-229. Bag-1 significantly slowed glioma cell growth and reduced clonogenicity of both cell lines in vitro. Coexpressed Bcl-2 abrogated these effects of Bag-1. Intracranial LN-229 glioma xenografts implanted into nude mice revealed a substantial growth advantage afforded by Bcl-2. Bag-1 had no such effect, either in the absence or presence of Bcl-2. Upon serum starvation in vitro, Bcl-2 prevented cell death whereas Bag-1 did not. Both Bcl-2 and Bag-1 slowed proliferation of serum-starved cells when expressed alone. Importantly, coexpression of Bcl-2 and Bag-1 provided a distinct growth advantage under conditions of serum starvation that is probably the result of (i) the death-preventing activity of Bcl-2 and (ii) the property of Bag-1 to overcome a Bcl-2-mediated enhancement of exit from the cell cycle. In contrast to these Bcl-2/Bag-1 interactions observed under serum starvation conditions, Bag-1 did not further enhance the strong protection from staurosporine-, CD95 (Fas/Apo1) ligand-, Apo2 ligand (TRAIL)- or chemotherapeutic drug-induced apoptosis afforded by Bcl-2. Taken together, these results indicate a role for Bag-1/Bcl-2 interactions in providing a survival advantage to cancer cells in a deprived microenvironment that may be characteristic of ischemic/hypoxic tumors such as human glioblastoma multiforme, and suggest that Bcl-2/Bag-1 interactions also modulate cell proliferation.