gebhart/patrepeval huggingface dataset:
Accelerated immune recovery following LLME treated donor lymphocyte infusion (2006)

Delayed immune reconstitution is a major cause of morbidity and mortality after T cell depleted allogeneic progenitor cell transplant (PCT). To accelerate immune reconstitution without GVHD, we have administered escalating doses of L-leucyl-L-leucine methyl ester (LLME) treated lymphocytes (DLI) to 18 patients post CD34+ cell-enriched PCT in an ongoing phase I trial. LLME’s cellular toxicity occurs after polymerization by dipeptidyl peptidase, leading to selective depletion of cells with cytotoxic effector granules containing perforin. Products treated with LLME demonstrated a median depletion of 94.9% CD56+ cells, 75.8 % CD8+ cells, but only 37.2% CD4+ cells. Patients initially received 10e4 (haploidentical (HAPLO)), 10e5 (HLA identical unrelated (URD)), or 10e6 (HLA identical sibling (SIB)) CD3+ cells/kg in cohorts of 3, and were eligible for additional infusions at a one log higher dose after 28 days if there was no evidence of GVHD or the CD4 count was less than the target of 100 cells/ml. The initial dose was escalated by one log in subsequent cohorts if no complications were observed in the previous cohort. Nine patients received grafts from SIBs (4 at 10e6, 5 at 10e7), six from URDs (3 at10e5, 3 at 10e6), and three from HAPLOs (3 at 10e4). All patients had pre-DLI CD4 counts of <5.0 cells/ml, and received 1 to 3 infusions post PCT. Since ATG was used during PCT cytoablation, the first DLI infusions were administered after ATG levels were <2 mcg/ml. After DLI #1, 6/8 evaluable matched SIB recipients and 2/6 evaluable URD recipients demonstrated early recovery of donor derived CD4+ cells prior to day 35 s/p DLI, with a median CD4 count of 139 cells/ul (range 57–471). Ten of these achieved a CD4+ count above 100 after 1–3 total infusions. In contrast, none of the haploidentical recipients (receiving the smallest doses) had an increase in CD4+ counts. Five patients developed GVHD (Grade I–II (n =4), Grade III (n = 1 following 4×10e7 LLME DLI). In recovering patients, spectratype analysis of CD4+ cells comparing DLI before LLME treatment with lymphocytes recovered from the patients post DLI demonstrated that 94% of the resolvable Vb families were equally complex. Perforin positive cells, as well as adenovirus (n = 2), EBV (n = 1) and CMV (n = 2) specific lymphocytes, also recovered post-PCT in these patients. These preliminary results suggest that LLME treated DLI can accelerate CD4+ reconstitution without causing severe GVHD.
Exploring the Design Space of SPMD Divergence Management on Data-Parallel Architectures (2014)

Data-parallel architectures must provide efficient support for complex control-flow constructs to support sophisticated applications coded in modern single-program multiple-data languages. As these architectures have wide data paths that process a single instruction across parallel threads, a mechanism is needed to track and sequence threads as they traverse potentially divergent control paths through the program. The design space for divergence management ranges from software-only approaches where divergence is explicitly managed by the compiler, to hardware solutions where divergence is managed implicitly by the micro architecture. In this paper, we explore this space and propose a new predication-based approach for handling control-flow structures in data-parallel architectures. Unlike prior predication algorithms, our new compiler analyses and hardware instructions consider the commonality of predication conditions across threads to improve efficiency. We prototype our algorithms in a production compiler and evaluate the tradeoffs between software and hardware divergence management on current GPU silicon. We show that our compiler algorithms make a predication-only architecture competitive in performance to one with hardware support for tracking divergence.
Structure of a Chiral Lithium Azaenolate: Monomeric, Intramolecular Chelated Lithio‐2‐acetylnaphthalene‐SAMP‐hydrazone (1988)

A more detailed insight into the structure of the 1-azaallyl anion of a SAMP-hydrazone has been made possible by the first X-ray crystallographic study of a chiral monomeric azaenolate. The lithiated 2-acetylnaphthalene-SAMP-hydrazone 1 exists as rubyred crystals; it has an η1-structure with intramolecular methoxychelatization, while the lithium ion is solvated by two THF molecules.
Metal Oxide Transistors via Polyethylenimine Doping of the Channel Layer: Interplay of Doping, Microstructure, and Charge Transport (2016)

Polymer doping of solution‐processed In 2 O 3 with small amounts of the electron‐rich polymer, polyethylenimine (PEI), affords superior transistor performance, including higher electron mobility than that of the pristine In 2 O 3 matrix. PEI doping of In 2 O 3 films not only frustrates crystallization and controls the carrier concentration but, more importantly, acts as electron dopant and/or scattering center depending on the polymer doping concentration. The electron donating capacity of PEI combined with charge trapping and variation in the matrix film microstructure yields, for optimum PEI doping concentrations of 1.0%–1.5%, electron mobilities as high as ≈9 cm 2 V −1 s −1 on a 300 nm SiO 2 gate dielectric, an excellent on/off ratio of ≈10 7 , and an application optimal V T . Importantly, these metrics exceed those of the pure In 2 O 3 matrix with a maximum mobility ≈4 cm 2 V −1 s −1 . Furthermore, we show that this approach is extendible to other oxide compositions such as IZO and the technologically relevant IGZO. This work opens a new means to fabricate amorphous semiconductors via solution processing at low temperatures, while preserving or enhancing the mobility of the pristine polycrystalline semiconductor.
Mixed cation effect in sodium aluminosilicate glasses (2014)

While the composition dependence of Vickers hardness of network glasses has received significant attention in the glass literature, the underlying deformation mechanisms and their respective resistances are not yet fully understood. Here, we investigate the relationship among Vickers hardness, network structure, and the resistances associated with the deformation processes in mixed cation glasses by partially substituting magnesium for calcium and calcium for lithium in sodium aluminosilicate glasses. We use Raman and 27Al NMR spectroscopies to obtain insights into the structural and topological features of these glasses and we use AFM to quantify the resistances associated with each deformation process under Vickers indentation. We demonstrate that the mixed cation effect manifests itself as a maximum in the amount of bonded tetrahedral units and as a minimum in liquid fragility index, glass transition temperature, Vickers hardness, and plastic flow. The observed minima in fragility, glass transition temperature, and plastic flow are ascribed to bond weakening in the local structural environment around the network modifiers. The elastic properties of the investigated system are found to be compositionally independent. Therefore, based on the AFM measurements, we suggest that the minimum in Vickers hardness is closely correlated to the minimum in plastic flow. Both of these properties are related to the translational motion of structural units, and hence, both may be related to the same underlying topological constraints.
Dexamethasone inhibition of interleukin 1 beta production by human monocytes. Posttranscriptional mechanisms. (1988)

Dexamethasone is known to have an inhibitory effect on IL-1 production. To determine the mechanism(s) of this inhibition, adherent human blood monocytes were stimulated with Escherichia coli lipopolysaccharide (LPS) (10 micrograms/ml) in the presence of dexamethasone. Nuclear transcription run-off assays showed that LPS induced IL-1 beta gene transcription two- to fourfold and that this induction was unaffected by dexamethasone exposure (10(-5) M). The lack of dexamethasone's transcriptional effects was further supported by the absence of any significant change in IL-1 beta mRNA accumulation between LPS-stimulated monocytes exposed or unexposed to dexamethasone, as determined by Northern blot analysis. Posttranscriptionally, dexamethasone was found to have multiple effects: slight prolongation of IL-1 beta mRNA half-life, moderate inhibition of translation of the IL-1 beta precursor, and profound inhibition of the release of IL-1 beta into the extracellular fluid. The data indicate that IL-1 beta is first translated as the 33,000-D pro-IL-1 beta protein, the predominant intracellular form, and the processed to a 17,500-D IL-1 beta protein before or during extracellular transport. The major inhibitory effects of dexamethasone appear to be directed at the translational and posttranslational steps involved in these events.
Induction of Tumor Necrosis Factor α Expression in Human T Lymphocytes Following Ionizing Gamma Irradiation (1996)

In this work, we present evidence that enriched human peripheral blood T lymphocytes, depleted of contaminating monocytes, rapidly express tumor necrosis factor alpha (TNF-alpha) mRNA when exposed to low doses of gamma-irradiation. In total PBL, TNF-alpha mRNA accumulation increased threefold as early as 30 minutes following exposure to 4 Gy and then declined to the baseline level by 3-5 h, as measured by the reverse transcriptase-polymerase chain reaction (RT-PCR). The increase in TNF-alpha mRNA was also observed in populations of enriched T cells and decreased when the dose of irradiation was increased to 10 Gy, strongly suggesting that T lymphocytes, the most radiosensitive cells of the body, contributed directly to the increase of TNF-alpha mRNA. A good correlation was found between mRNA expression and TNF-alpha protein secretion. Interestingly, a eightfold increase in glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA accumulation was also detected in both PBL and enriched T cells irradiated at 4 Gy for 3 h compared with unirradiated cells. This irradiation effect was almost completely abolished, however, following exposure to 10 Gy. Together these data suggest that T cells are responsible for the irradiation-induced expression of TNF-alpha and GAPDH.
Green chemistry and polymers made from sulfur (2017)

Polysulfide polymers prepared from elemental sulfur have found increasing use in applications that benefit the environment.
Cryptococcus neoformans laccase catalyses melanin synthesis from both d- and l-DOPA (2007)

The human fungal pathogen Cryptococcus neoformans produces melanin in the presence of various substrates, including the L enantiomer of 3,4-dihydroxyphenylalanine (DOPA). The enzyme laccase catalyses the formation of melanin by oxidizing L-DOPA, initiating a series of presumably spontaneous reactions that ultimately leads to the polymerization of the pigment in the yeast cell wall. There, melanin protects the cell from a multitude of environmental and host assaults. Thus, the ability of C. neoformans to produce pigments from a variety of available substrates is likely to confer a survival advantage. A number of C. neoformans isolates of different serotypes produced pigments from D-DOPA, the stereoisomer of L-DOPA. Acid-resistant particles were isolated from pigmented C. neoformans cells grown in the presence of D-DOPA. Biophysical characterization showed the particles had a stably detectable free-radical signal by EPR, and negative zeta potential, similar to L-DOPA-derived particles. No major differences were found between L- and D-DOPA ghosts in terms of binding to anti-melanin antibodies, or in overall architecture when imaged by electron microscopy. C. neoformans cells utilized L- and D-DOPA at a similar rate. Overall, our results indicate that C. neoformans shows little stereoselectivity for utilizing DOPA in melanin synthesis. The ability of C. neoformans to use both L and D enantiomers for melanization implies that this organism has access to a greater potential pool of substrates for melanin synthesis, and this could potentially be exploited in the design of therapeutic inhibitors of laccase.
ATTENUATED METHACHOLINE AIRWAY RESPONSE FOLLOWING REPEAT TESTING IN A MURINE MODEL OF ALLERGIC AIRWAYS DISEASE (2008)

A progressive attenuation of airway reactivity to methacholine is observed in normal individuals with successive bronchial provocation testing. The absence of this attenuation in asthma is thought to be due airway inflammation. The authors investigated this phenomenon in a mouse model of allergic airways disease. Repeated measurements of airway response were carried out in mice sensitized/challenged with ovalbumin or saline, and in untreated mice. Saline-treated and untreated mice showed reduced airway reactivity following repeated testing. This was also observed in ovalbumin-treated mice in the second and third tests compared to the previous test (P < .05). This attenuation was not associated with airway inflammation, which remained high in the ovalbumin group. The results suggest that attenuation of airway reactivity with repeated methacholine challenge is due to factors other than airway inflammation.
Investigation of Interplay between Polyvinylpyrrolidone Interlayer and Perovskite Composition Affecting the Performance of Perovskite Light Emitting Diode (2021)

Abstract Device structure and perovskite composition are two of the most important factors for maximizing the efficiency of light emitting diodes with perovskite as the light emitting layer. However, combining the best structures reported does not necessarily lead to better device performance. In the present study, the authors examine the device performance affected by the interplay between polyvinylpyrrolidone (PVP) as the interlayer and cesium (Cs)‐ or formamidinium (FA)‐based perovskite composition (PEA 2 (Cs 0.87 MA 0.13 ) 4 Pb 5 Br 16 (PEA: phenyl ethyl ammonium cation, MA: methyl ammonium cation) or PEA 2 FA 2 Pb 3 Br 10 , respectively). In the case of Cs‐based perovskite light‐emitting diodes (PeLEDs), PVP improves the formation of perovskite by preventing intermixing at the interface, thereby improving the device efficiency. On the other hand, although PVP is thought to behave similarly on FA‐based perovskite, it degrades device efficiency by decreasing hole injection and shifting the charge balance due to its insulating property. Based on the analysis, high efficiency Cs‐ and FA‐based PeLEDs of 12.31 and 24.5 cd A −1 , respectively, are obtained.
Biological rhythms and mood disorders (2024)

Integration of several approaches concerning time and temporality can enhance the pathophysiological study of major mood disorders of unknown etiology. We propose that these conditions might be interpreted as disturbances of temporal profile of biological rhythms, as well as alterations of time-consciousness. Useful approaches to study time and temporality include philological suggestions, phenomenological and psychopathological conceptualizatíons, clinical descriptions, and research on circadian and ultradían rhythms, as well as nonlinear dynamics approaches to their analysis.
Energy Efficient Access Point Placement for Distributed Massive MIMO (2022)

Distributed massive multiple-input multiple-output (D-mMIMO) is one of the key candidate technologies for future wireless networks. A D-mMIMO system has multiple, geographically distributed, access points (APs) jointly serving its users. First of all, this paper reports on where to position these APs to minimize the overall transmit power in actual deployments. As a second contribution, we show that it is essential to take into account both the radiation pattern of the antenna array and the environment information when optimizing AP placement. Neglecting the radiation pattern and environment information, as generally assumed in the literature, can lead to a power penalty in the order of 15 dB and 20 dB, respectively. These results have been obtained by formulating the AP placement optimization problem as a combinatorial optimization problem, which can be solved with different approaches where different channel models are applied. The proposed graph-based channel model drastically lowers the computational time with respect to using an ray-tracing simulator (RTS) for channel evaluation. The performance of the graph-based approach is validated via the RTS, showing that it achieves 5 dB power saving on average compared with a Euclidean distance-based approach, which is the most commonly used approach in the literature.
A Multi-O2 Complex Derived from a Copper(I) Dendrimer (1999)

Bis[2-(2-pyridyl)ethyl]amine derivatives (n = 1–4) of a number of generations of poly(propylene imine)dendrimers (DAB-dendr-(NH2)m (m = 4, 8, 16, 32) have been prepared, and their complexations with ZnII, CuII, CuI ions studied. The CuI complex of the fourth-generation dendrimer is shown to bind oxygen.
Auditory model inversion for sound separation (2002)

Techniques to recreate sounds from perceptual displays known as cochleagrams and correlograms are developed using a convex projection framework. Prior work on cochlear-model inversion is extended to account for rectification and gain adaptation. A prior technique for phase recovery in spectrogram inversion is combined with the synchronized overlap-and-add technique of speech rate modification, and is applied to inverting the short-time autocorrelation function representation in the auditory correlogram. Improved methods of initial phase estimation are explored. A range of computational cost options, with and without iteration, produce a range of quality levels from fair to near perfect.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Analysis of pointers and structures (1990)

article Free Access Share on Analysis of pointers and structures Authors: David R. Chase View Profile , Mark Wegman IBM T. J. Watson Research Center, P.O. Box 704, Yorktown, Heights, NY IBM T. J. Watson Research Center, P.O. Box 704, Yorktown, Heights, NYView Profile , F. Kenneth Zadeck Computer Science Dept., P.O. Box 1910, Brown University, Providence Computer Science Dept., P.O. Box 1910, Brown University, ProvidenceView Profile Authors Info & Claims ACM SIGPLAN NoticesVolume 25Issue 6Jun. 1990 pp 296–310https://doi.org/10.1145/93548.93585Published:01 June 1990Publication History 438citation2,542DownloadsMetricsTotal Citations438Total Downloads2,542Last 12 Months131Last 6 weeks37 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
ATR-FTIR spectroscopic studies on density changes of fused silica induced by localized CO 2 laser treatment (2015)

The surface density changes of the central region of the sites treated by using the CO2 laser-based non-evaporative damage mitigation for fused silica are investigated by attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR). The ATR-FTIR peak shifts of the treated sites of fused silica are monitored to determine the changes of the corresponding density. For the quenching treated sites, the surface density is increased by (0.24 ± 0.01)% compared with the initial density but the laser annealing by the exposure of a power ramp down after damage mitigation effectively suppresses the structural changes of treated sites, which could reduce the increase of the corresponding density to (0.08 ± 0.01)%. The results provide sufficient evidence that the laser annealing by a power ramp down after damage mitigation has a positive effect on the control of the structural change induced by CO2 laser-based damage mitigation.
343 EFFECTS OF EPIDERMAL GROWTH FACTOR SUPPLEMENTATION ON IN VITRO MATURATION AND GENE EXPRESSION OF CANINE OOCYTES (2005)

Despite many efforts to improve canine in vitro maturation (IVM), the efficiency is still low compared to that of other mammalian species (Marie et al . 2004). Epidermal growth factor (EGF) has stimulatory effects on the resumption of oocyte maturation and cumulus expansion in vitro and on prei-mplantation embryonic development in mammals by either an autocrine or a paracrine pathway, or a combination of both systems (Paria et al . 2001 PNAS 98, 1047-1052). The present study investigated the effects of EGF supplementation on in vitro maturation and gene expression of canine oocytes. Oocytes were recovered by slicing ovaries recovered from 40 bitches after ovariohysterectomy at random stages of the estrous cycle. Cumulus-oocyte complexes (COCs) were matured in TCM-199 containing 10% FBS, 1 ¼g/mL FSH and LH, and EGF (0, 10, or 30 ng/mL) for 48 or 72 h at 39°C in a humidified atmosphere of 5% CO2 in air. In Experiment I ( n = 2520 oocytes), the nuclear maturation status was assessed by fluorescence microscopy after bisbenzimide (Hoechst 33342) staining (10 µg/mL) at 0, 48, and 72 h of incubation. In Experiment II ( n = 90 oocytes), expression of transcripts such as EGF receptor ( EGFR ), luteinizing hormone receptor ( LHR ), and gap junction protein ( GJA5 ) were determined in 10 intact COCs each at 0, 48, and 72 h, respectively, by reverse transcription-polymerase chain reaction (RT-PCR). At 0 h 10-20% of the oocytes had undergone resumption of meiosis (GVBD&amp;lt;MII). After 48 h of IVM, rate of meiotic resumption for 0, 10, and 30 ng/mL EGF were 28, 35, and 30%, respectively. At 72 h of IVM, oocytes in the 10 ng/mL EGF group had resumed meiosis at a higher frequency (55%; P &amp;lt; 0.05) than in the 30 ng/mL EGF or the control group (39 and 42%, respectively). At 72 h of IVM, the frequency of maturation to the MII stage was significantly higher in the 10 ng/mL EGF group (9.6%) than in the 30 ng/mL EGF or the control group (4.2 and 3.3%, respectively). The expression of EGFR was significantly higher ( P &amp;lt; 0.05) in 0 h oocytes than in the 48- or 72-h oocytes. Further EGFR expression levels were decreased in the presence of EGF in a dose dependent manner. Transcripts for LHR were detected at all maturation intervals and its expression patterns were not altered by supplementation with 10 ng/mL EGF. Expression of GJA5 was observed only after 48 h of IVM, and levels of expression were similar in oocytes supplemented with both 10 and 30 ng/mL EGF. In summary, our results indicate that supplementation of canine IVM medium with 10 ng/mL EGF had a positive influence on the progression of maturation to MII at 72 h. The effect may not be related to the alteration of mRNA expression of genes analyzed in the present study, due to the complex patterns regulating meiotic arrest in canine oocytes. This work was supported by Grant no. 204119-03-1-LG000 from ARPC, Republic of Korea.