gebhart/patrepeval huggingface dataset:
Identification of novel attenuatedSalmonellaEnteritidis mutants (2008)

Salmonella Enteritidis is a major food-borne pathogen that causes nontyphoidal diarrhoea in humans. Infection of adult egg-laying hens usually results in symptomless carriage but in young chicks it may cause paratyphoid disease. It is not known whether S. Enteritidis requires genes additional to known virulence genes for systemic infection of young chickens. A transposon insertion library was created using S. Enteritidis 10/02, which yielded 1246 mutants. Of 384 mutants screened in chickens for attenuation (30.8% of insertion library), 12 (3.1%) had a 50% lethal dose at least 100 times that of the parental strain. Sequencing revealed insertions in genes involved in the biosynthesis of lipopolysaccharide, cell membrane, ATP biosynthesis, transcriptional regulation of virulence and the yhbC gene, which has an unknown function. Evaluation of in vitro virulence characteristics of a Delta yhbC mutant revealed that its ability to invade HeLa cells and survive within a chicken macrophage cell line (HD11) was significantly reduced. It was also less resistant to reactive oxygen and nitrogen intermediates and had a retarded growth rate. Chickens challenged with the Delta yhbC mutant cleared the organism from the liver and spleen 1 week faster than the parental strain and were able to develop specific serum IgG antibodies against the Delta yhbC mutant.
The impact of scanner model vectorization on optical proximity correction (2007)

Low pass filtering taking place in the projection tools used by IC industry leads to a range of optical proximity effects resulting in undesired IC characteristics. To correct these predicable OPEs, EDA industry developed various, model-based correction methodologies. Of course, the success of this mission is strongly dependent on how complete the imaging models are. To represent the image formation and to capture the OPEs, the EDA community adopted various models based on simplified representations of the projection tools. Resulting optical proximity correction models are capable of correcting OPEs driven by the fundamental imaging conditions such as wavelength, illuminator layout, reticle technology, and lens numerical aperture, to name a few. It is well known in the photolithography community that OPEs are dependent on the scanner characteristics. Therefore, to reach the level of accuracy required by the leading edge IC designs, photolithography simulation has to include systematic scanner fingerprint data. These tool fingerprints capture excursions of the imaging tools from the ideal imaging setup conditions. They quantify the performance of key projection tool components such as illuminator and lens signatures. To address the imaging accuracy requirements, the scanner engineering and the EDA communities developed OPC models capable of correcting for imaging tools engineering attributes captured by the imaging tools fingerprints. Deployment of immersion imaging systems has presented the photolithography community with new opportunities and challenges. These advanced scanners, designed to image in deep sub-wavelength regime, incorporate features invoking the optical phenomena previously unexplored in commercial scanners. Most notably, the state of the art scanners incorporate illuminators with high degree of polarization control and projection lenses with hyper-NAs. The image formation in these advanced projectors exploits a wide range of vectorial interactions originating at the illuminator, on the pattern mask, in the projection lens and at the wafer. The presence of these, previously subdued phenomena requires that the imaging simulation methodologies be refined, increasing the complexity of the OPE models and optical proximity correction methodologies.
Practical resource scheduling and power control optimization for LTE femtocell networks (2011)

This paper presents a proposal for interference avoidance in Long Term Evolution (LTE) femtocells by using a simple distributed frequency-domain resource allocation and power optimization. A downlink frequency-domain scheduling approach is proposed to roughly separate the macro- and femtocell resource allocation with a small signaling load increase from macrocell to femtocells. The scheduling approach is also modified to fit single-carrier operation in LTE uplink. Extensive simulations are carried out with LTE system compliance and results show the proposed scheduler effectively improves the system throughput up to a moderate resource utilization.
Enabling Ideal Selective Solar Absorption with 2D Metallic Dielectric Photonic Crystals (2014)

A metallic dielectric photonic crystal with solar broadband, omni-directional, and tunable selective absorption with high temperature stable (1000 °C, 24 hrs) properties is fabricated on a 6 silicon wafer. The broadband absorption is due to a high density of optical cavity modes overlapped with an anti-reflection coating. Results allow for large-scale, low cost, and efficient solar-thermal energy conversion.
Prunier et al. Supplementary information from LIM Kinase Inhibitor Pyr1 Reduces the Growth and Metastatic Load of Breast Cancers (2023)

&lt;p&gt;Supplementary information, i.e. suppplementary table, supplemenatry figures and movies legends and supplementary materiel and methods&lt;/p&gt;
Biological activity tuning of antibacterial urotropineviaco-crystallization: synthesis, biological activity evaluation and computational insight (2020)

Urotropine (<bold>1</bold>) is a synthetic heterocyclic antibacterial agent.
HAMLET, a Protein Complex from Human Milk, Has Bactericidal Activity and Enhances the Activity of Antibiotics against Pathogenic Streptococci (2019)

HAMLET is a protein-lipid complex derived from human milk that was first described for its tumoricidal activity. Later studies showed that HAMLET also has direct bactericidal activity against select species of bacteria, with highest activity against <i>Streptococcus pneumoniae</i> Additionally, HAMLET in combination with various antimicrobial agents can make a broader range of antibiotic-resistant bacterial species sensitive to antibiotics. Here, we show that HAMLET has direct antibacterial activity not only against pneumococci, but also against <i>Streptococcus pyogenes</i> (GAS) and <i>Streptococcus agalactiae</i> (GBS). Analogous to pneumococci, HAMLET-treatment of GAS and GBS resulted in depolarization of the bacterial membrane followed by membrane permeabilization and death that could be inhibited by calcium and sodium transport inhibitors. Treatment of clinical antibiotic-resistant isolates of <i>S. pneumoniae</i>, GAS, and GBS with sublethal concentrations of HAMLET in combination with antibiotics decreased the minimal inhibitory concentrations of the respective antibiotic into the sensitive range. This effect could also be blocked by ion transport inhibitors, suggesting that HAMLET's bactericidal and combination treatment effects used similar mechanisms. Finally, we show that HAMLET potentiated the effects of erythromycin against erythromycin-resistant bacteria more effectively than it potentiated killing by penicillin G of bacteria resistant to penicillin G. These results show for the first time that HAMLET effectively kills three different species of pathogenic <i>Streptococci</i> using similar mechanisms and also potentiate the activity of macrolides and lincosamides more effectively than combination treatment with beta-lactams. These findings suggest a potential therapeutic role for HAMLET in repurposing antibiotics currently causing treatment failures in patients.
Primary leiomyosarcoma of bone (1977)

A case of primary leiomyosarcoma of bone in the femur of an 18-year-old girl is described. Light and electron microscopy showed characteristic changes with cytoplasmic myofilaments, dense bodies, pinocytic vesicles and basal lamina fragments. Clinically, the patient is well and without evidence of tumor 9 months after the femur amputation without further treatment.
Actividad inhibidora de la enzima convertidora de angiotensina en leches fermentadas con cepas deLactobacillusAngiotensin converting enzyme inhibitory activity in milks fermented byLactobacillusstrains (2011)

The objective of this work was to determine and compare the angiotensin converting enzyme inhibitory activity (ACEI) of milks fermented with different Lactobacillus strains to assess their antihypertensive potential. Additionally, the acidification and proteolytic activities of eight Lactobacillus strains were evaluated and compared after 6, 12, 24 and 48 h of incubation in reconstituted skimmed milk. ACEI activity was evaluated and compared after 24 h. Results showed that Lb. helveticus was the strain that had the highest proteolytic activity of all the strains tested. However, fermented milks from all different species showed ACEI-activity (42.04–86.36%); the highest inhibition was achieved in decreasing order by Lb. reuteri, Lb. johnsonii and Lb. helveticus, respectively. The smallest IC50 of all (21 μg mL−1) was produced by Lb. fermentum. Therefore, Lb. fermentum could be a useful multifunctional strain in fermented products since it may not only provide important technological advantages, but also antihypertensive properties. El objetivo del presente trabajo fue determinar y comparar la actividad inhibidora de la enzima convertidora de angiotensina (ECA) en leches fermentadas con diferentes cepas de Lactobacillus con el propósito de explorar su potencial efecto antihipertensivo. Para ello evaluamos y comparamos la capacidad acidificante y proteolítica de ocho especies de Lactobacillus a las 6, 12, 24 y 48 h de fermentación en leche en polvo desnatada reconstituida (LPDR). Asimismo, la actividad inhibidora de la ECA fue evaluada y comparada a las 24 h de fermentación. Los resultados mostraron que el Lb. helveticus fue la cepa que presentó la mayor actividad proteolítica. Aunque todas las leches fermentadas mostraron actividad inhibidora de la ECA (42,04–86,36%), la mayor actividad fue mostrada por Lb. reuteri, Lb. johnsonii y Lb. helveticus, respectivamente. Sin embargo el IC50 más bajo (21 μg mL−1) fue mostrado por Lb. fermentum.
Remote atrial fibrillation burden estimation using deep recurrent neural\n network (2020)

The atrial fibrillation burden (AFB) is defined as the percentage of time\nspend in atrial fibrillation (AF) over a long enough monitoring period. Recent\nresearch has demonstrated the added prognosis value that becomes available by\nusing the AFB as compared with the binary diagnosis. We evaluate, for the first\ntime, the ability to estimate the AFB over long-term continuous recordings,\nusing a deep recurrent neutral network (DRNN) approach. Methods: The models\nwere developed and evaluated on a large database of p=2,891 patients, totaling\nt=68,800 hours of continuous electrocardiography (ECG) recordings acquired at\nthe University of Virginia heart station. Specifically, 24h beat-to-beat time\nseries were obtained from a single portable ECG channel. The network, denoted\nArNet, was benchmarked against a gradient boosting (XGB) model, trained on 21\nfeatures including the coefficient of sample entropy (CosEn) and AFEvidence.\nData were divided into training and test sets, while patients were stratified\nby the presence and severity of AF. The generalizations of ArNet and XGB were\nalso evaluated on the independent test PhysioNet LTAF database. Results: the\nabsolute AF burden estimation error |E_AF|, median and interquartile, on the\ntest set, was 1.2 (0.1-6.7) for ArNet and 3.1 (0.0-11.7) for XGB for AF\nindividuals. Generalization results on LTAF were consistent with E_AF of 2.6\n(1.1-14.7) for ArNet and 3.6 (1.0-16.7) for XGB. Conclusion: This research\ndemonstrates the feasibility of AFB estimation from 24h beat-to-beat interval\ntime series utilizing recent advances in DRNN. Significance: The novel\ndata-driven approach enables robust remote diagnosis and phenotyping of AF.\n
The above-threshold linewidth enhancement factor of silicon-based quantum dot lasers (2021)

The spectral dependence of the linewidth enhancement factor of silicon based InAs/GaAs quantum dot lasers is investigated above the threshold by using a phase modulation method. Low values of linewidth enhancement factor measured at twice the threshold are reported. Such results confirm the high quality of the quantum dot material.
An FPGA-based all-digital transmitter with 28-GHz time-interleaved delta-sigma modulation (2016)

An FPGA-based all-digital transmitter with 28-GHz ΔΣ-modulation is presented. For improving the operation frequency of ΔΣ modulator (DSM), a multi-channel look-ahead time-interleaved ΔΣ modulator is proposed. By implementing the proposed DSM in an FPGA, 28-GHz operation of DSM has been achieved. Furthermore, FPGA-based all-digital transmitter integrating the proposed DSM can satisfy the spectral mask of IEEE 802.11a WLAN standard in 5.2-GHz band. To the best of our knowledge, this is the first demonstration of an FPGA-based all-digital transmitter which can directly generate 5-GHz band WLAN signal.
Sex Differences in Proportion of Calcified Articular Cartilage in Rats (2011)

Females have a higher incidence of osteoarthritis (OA) than males. The mechanisms responsible for these differences are not well understood. Calcified cartilage is softer and has lower stiffness than subchondral bone and is thought to play a role in the inflammation that accompanies OA. If females have a higher proportion of calcified cartilage than males it may help to explain their higher susceptibility to OA. PURPOSE: To determine the sex specific differences in the proportion of calcified cartilage in rat knees. METHODS: The right knees of six male and six female 14 week old Sprague-Dawley rats were harvested and stored in formalin for 24 hours. Medial femoral condyles were dehydrated in sequential ethanolic gradients and paraffin embedded per standard histological technique. Seven micrometer sections at 100uM intervals and slides were stained with Saffranin O, Masson's trichrome, and Hematoxylin and Eosin. Stained sections were viewed with Image J software. The width of the articular cartilage and calcified section to the tide mark were measured along the weight bearing portion of the femur. The proportion of calcified cartilage to articular cartilage was used in Mann-Whitney non-parmetric analysis. RESULTS: Female rats (57.0) had a higher proportion of calcified cartilage than males (21.0) (P=.002). CONCLUSIONS: Females had a higher proportion of calcified cartilage in the articular surface of their knees than males. Sex specific differences in the proportion of calcified articular cartilage may contribute to a softer articular surface in female than in male rats. Supported by NIAMS Grant 5R03AR054573-03.
Development of an occult metric for common motor vehicle crash injuries - biomed 2013. (2013)

Detection of occult injuries, which are not easily recognized and are life-threatening, in motor vehicle crashes (MVCs) is crucial in order to reduce fatalities. An Occult Injury Database (OID) was previously developed by the Center for Transportation Injury Research (CenTIR) using the National Automotive Sampling System Crashworthiness Data System (NASS-CDS) 1997-2001 which identified occult and non-occult head, thorax, and abdomen injuries. The objective of the current work was to develop an occult injury model based on underlying injury characteristics to derive an Occult Score for common MVC-induced injuries. A multiple logistic regression model was developed utilizing six injury parameters to generate a probability formula which assigned an Occult Score for each injury. The model was applied to a list of 240 injuries comprising the top 95 percent of injuries occurring in NASS-CDS 2000-2011. The parameters in the model included a continuous Cause MRR/year variable indicating the annual proportion of occupants sustaining a given injury whose cause of death was attributed to that injury. The categorical variables in the model were AIS 2-3 vs. 4-6, laceration, hemorrhage/hematoma, contusion, and intracranial. Results indicated that injuries with a low Cause MRR/year and AIS severity of 4-6 had an increased likelihood of being occult. In addition, the presence of a laceration, hemorrhage/hematoma, contusion, or intracranial injury also increased the likelihood of an injury being occult. The Occult Score ranges from zero to one with a threshold of 0.5 as the discriminator of an occult injury. Of the considered injuries, it was determined that 54% of head, 26% of thorax, and 23% of abdominal injuries were occult injuries. No occult injuries were identified in the face, spine, upper extremity, or lower extremity body regions. The Occult Score generated can be useful in advanced automatic crash notification research and for the detection of serious occult injuries in MVCs requiring prompt treatment at a trauma center.
SEU of Complementary GaAs Static Rams Due to Heavy Ions (1984)

The first measurement of single event upset (SEU) for complementary GaAs static RAMs caused by heavy ions is reported. Upset cross-sections of the circuits for 28 MeV oxygen ions are reported as well as the linear energy transfer (LET) threshold established by using 170 MeV oxygen ions at various angles of beam incidence.
Enhancing Water Use Efficiency and Yield of Pomegranate Crop by Using Fish Drainage Water with Bio-Fertilizer under Drip Irrigation System (2022)

Fish drainage water is a non-conventional water resource that can be exploited for irrigation due to its constituents of beneficial nutrients, signifying it as environment-friendly bio-fertilizers. Limited water resources, the elevated cost of mineral fertilizers hazards as well as attaining healthy food are of paramount significance in the agriculture sector in Egypt. The utilization of bio-fertilizers is an avenue to fulfil agricultural sustainability, production of clean crops and preservation of the soil from the accumulation of heavy metals and chemicals. Hence, this study aims to find non-conventional alternative water resources to be used for irrigation of pomegranate fruit yield. Two resources of water were utilized, and three types of bio-fertilizers were applied. Results showed that, fish drainage water increased the total yield (kg/fed) by 25.2% as compared to freshwater. Chicken manure increased the total yield (kg/fed) by 22.37 and 11.89% in comparison with cattle and compost organic fertilizer under fish drainage water, respectively. The use of chicken manure yielded the highest net return (2420.79US $/fed), while compost and cattle dung were found to be (2123.52US $/fed) and (1721.66US $/fed), respectively, under using fish drainage water. The study showed that the use of fish drainage water as an organic resource would be an alternative to commercial fertilizers, which could reduce the total cost and thus increase the net profit and yield. Less dependency of commercial fertilizer would have an impact on reducing the emissions of CO2 mitigating global warming.
Adult human nasal mesenchymal stem cells have an unexpected broad anatomic distribution (2013)

The unanticipated broad anatomic distribution of nasal MSCs has implications for cell-based therapy research.
Fast Connectivity Restoration Using BGP Add-path (2013)

A BGP route defines an association of an address prefix with an exit
point from the current Autonomous System (AS). If the exit point
becomes unreachable due to a failure, the route becomes invalid. This
usually triggers an exchange of BGP control messages after which a new
BGP route for the given prefix is installed. However, connectivity can
be restored more quickly if the router maintains precomputed BGP
backup routes. It can then switch to a backup route immediately upon
learning that an exit point is unreachable, without needing to wait
for the BGP control messages exchange. This document specifies the
procedures to be used by BGP to maintain and distribute the
precomputed backup routes. Maintaining these additional routes is also
useful in promoting load balancing, performing maintenance without
causing traffic loss, and in reducing churn in the BGP control plane.
Automated Computer-derived Prostate Volumes from MR Imaging Data: Comparison with Radiologist-derived MR Imaging and Pathologic Specimen Volumes (2011)

MFAs with axial T2-weighted MR imaging provided an automated and efficient tool with which to assess PV. Both MFAs and MR imaging planimetry require adjustments for optimized PV accuracy when compared with prostatectomy specimens.
Automatic partitioning techniques for solving partial differential equations on irregular adaptive meshes (1996)

We present some original automatic partitioning techniques for irregular sparse matrices arising from Finite-Element discretizations of PDE. We discuss their efficiency in terms of parallel computation, especially from the point of view of adaptive applications, that need rebalancing after small changes on the grid. Some parallel simulations are presented, along with practical experiments on a KSR and a SGI-Challenge. 1
Gapless magnetic excitation in a heavily electron-doped antiferromagnetic phase of LaFeAsO0.5D0.5 (2018)

Magnetic excitations in a heavily electron-doped antiferromagnet, ${\mathrm{LaFeAsO}}_{0.5}{\mathrm{D}}_{0.5}$, have been investigated using powder inelastic neutron scattering. Unlike other parent compounds of the iron-based superconductors, the magnetic excitation gap in ${\mathrm{LaFeAsO}}_{0.5}{\mathrm{D}}_{0.5}$ was not detected down to the lowest measured temperature of 4 K. This result can be understood as a result of quasi-isotropy within the $ab$ plane, which is consistent with the band calculation result that the ${d}_{xy}$ orbital plays the dominant role in the magnetism of ${\mathrm{LaFeAsO}}_{0.5}{\mathrm{H}}_{0.5}$. In addition, the intensities of the magnetic excitations in this phase are much stronger than those in nondoped LaFeAsO. Even in the paramagnetic phase, the magnetic excitation in ${\mathrm{LaFeAsO}}_{0.5}{\mathrm{D}}_{0.5}$ persists. These results corroborate recent studies showing that the electron doping enhances the localized nature in this system.
Supplementary Figure 3 from Global Evaluation of Eph Receptors and Ephrins in Lung Adenocarcinomas Identifies EphA4 as an Inhibitor of Cell Migration and Invasion (2023)

&lt;p&gt;PDF file, 48K, Ephs and eprins in vivo.&lt;/p&gt;
ChemInform Abstract: Structural Characterization and Catalytic Behavior of Al2O3‐Supported Cerium Oxides. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.