gebhart/patrepeval huggingface dataset:
GeoSpatial Access Control for Mobile Devices (2015)

Access control has been applied in various scenarios in the past for negotiating the best policy. Solutions with XACML for access control has been very well explored by research and have resulted in significant contributions to various sectors including healthcare. In controlling access to the sensitive data such as medical records, it is important to guarantee that the data is accessed by the right person for the right reason. Location of access requestor can be a good indication for his/her eligibility and reasons for accessing the data. To reason with geospatial information for access control, Geospatial XACML (Extensible Access Control Markup Language) is proposed as a standard. However, there is no available implementation and architecture for reasoning with Geospatial XACML policies. This paper propose to extend XACML with geohashing to implement geospatial policies. It also proposes an architecture for checking reliability of the geospatial information provided by clients. With a case study, we demonstrate how our framework can be used to control the privacy and data access of health service data in handheld devices.
Multiscale imaging of therapeutic anti-PD-L1 antibody localization using molecularly defined imaging agents (2022)

A set of molecularly defined multimodal antibody-based PD-L1 imaging agents were synthesized and validated for multiscale monitoring of PD-L1 expression and localization. Our modular approach for site-specific functionalization could easily be adapted to other targets.
Characterization of Organic Epitaxial Films by Atomic Force Microscopy (1995)

Abstract The initial stage of the epitaxial growth of vanadyl-phthalocyanine (VOPc) films on alkali halides (AH) and MoS2 was studied by atomic force microscopy. Each grain grew epitaxially on the surface with its crystal axis parallel to that expected from the molecular arrangements determined by reflection high energy electron diffraction. The growth mode of the VOPc films on AH was the Volmer- Weber type. Although the height of the grains increased with the deposition time, the grains hardly enlarged in the lateral direction. The shape of grains was affected even by steps with atomic height on AH. On the other hand, the nuclei grew rapidly in the lateral direction on MoS2. The diffusion length of VOPc on MoS2 was estimated to be six times as long as that on KBr at room temperature. Large domains with flat surfaces were observed on a MoS2 surface when the substrate temperature was kept at 100°C during film growth.
An assumption-based combinatorial optimization system (2003)

An assumption-based combinatorial optimization system is proposed for solving combinatorial optimization problems. The assumption-based combinatorial optimization system is a local search method in which a solution is formulated as a set of assumptions. Minimal support for the objective function is a minimal set of assumptions that guarantee the value of the objective function. Using minimal support, the system finds an approximate optimal solution efficiently because it: reduces the number of neighbors, defends the loop of a search and prunes search space, and never stays at a local optimal solution. The system was applied to a jobshop scheduling problem, and the system's effectiveness compared with other methods was demonstrated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Diffuse large B-cell lymphoma and related entities—diagnosis, treatment, and follow-up (2023)

This clinical practice guideline on the diagnosis, treatment, and followup of patients with DLBCL and related entities provides a standardized clinical management approach, identifies areas where improvement would be desirable, and can serve as a basis for the development of further studies.
I3Mote: An Open Development Platform for the Intelligent Industrial Internet (2017)

In this article we present the Intelligent Industrial Internet (I3) Mote, an open hardware platform targeting industrial connectivity and sensing deployments. The I3Mote features the most advanced low-power components to tackle sensing, on-board computing and wireless/wired connectivity for demanding industrial applications. The platform has been designed to fill the gap in the industrial prototyping and early deployment market with a compact form factor, low-cost and robust industrial design. I3Mote is an advanced and compact prototyping system integrating the required components to be deployed as a product, leveraging the need for adopting industries to build their own tailored solution. This article describes the platform design, firmware and software ecosystem and characterizes its performance in terms of energy consumption.
The phosphoproteome of Fusarium graminearum at the onset of nitrogen starvation (2009)

Fusarium graminearum grown under stress, such as nutrient deprivation, activates, among others, the trichothecene pathway that produces the mycotoxin deoxynivalenol and its derivatives. The kinase inhibitor staurosporine reduced the production of trichothecenes by 39% compared with control in vitro. On the other hand, phosphatase inhibitor okadaic acid increased the amount by 72% compared with the control in vitro. This suggests that phosphorylation events are involved in the signalling pathway, leading to the activation of the trichothecene pathway. Three approaches were used to study the phosphoproteome of F. graminearum under nitrogen-limiting conditions: 2-DE (2-DE: IEFxSDS-PAGE) in combination with MS protein identification; SDS-PAGE in combination with off-line IMAC and TiO(2) enrichment and gel electrophoresis LC-MS analysis; and a gel-free approach using strong anion exchange chromatography, IMAC and LC-MS. A total of 348 phosphorylation sites localized in 301 peptides from 241 proteins were identified. By 2-DE, 20 phosphoproteins were identified, nine of which underwent changes during the time course examined. Using gel electrophoresis LC-MS 231 phosphopeptides were identified from three samples (ten gel slices each) at time points of nitrogen starvation t=0, 6, and 12 h. The gel-free analysis added 70 peptides from 65 proteins to the total. Proteins of unknown function and enzymes of known function comprised the largest groups overall. Ten protein kinases and seven transcription factors were identified. This is the first reported phosphoproteome of F. graminearum.
Drivers and determinants of strain dynamics following fecal microbiota transplantation (2022)

Fecal microbiota transplantation (FMT) is a therapeutic intervention for inflammatory diseases of the gastrointestinal tract, but its clinical mode of action and subsequent microbiome dynamics remain poorly understood. Here we analyzed metagenomes from 316 FMTs, sampled pre and post intervention, for the treatment of ten different disease indications. We quantified strain-level dynamics of 1,089 microbial species, complemented by 47,548 newly constructed metagenome-assembled genomes. Donor strain colonization and recipient strain resilience were mostly independent of clinical outcomes, but accurately predictable using LASSO-regularized regression models that accounted for host, microbiome and procedural variables. Recipient factors and donor-recipient complementarity, encompassing entire microbial communities to individual strains, were the main determinants of strain population dynamics, providing insights into the underlying processes that shape the post-FMT gut microbiome. Applying an ecology-based framework to our findings indicated parameters that may inform the development of more effective, targeted microbiome therapies in the future, and suggested how patient stratification can be used to enhance donor microbiota colonization or the displacement of recipient microbes in clinical practice.
Optical Pickup for Recording to Dual-Layer 2x-Speed Blu-Ray Disc, DVD and Compact Disc (2006)

An ordinary half-height size optical pickup with high light-use efficiency for Blu-ray Discs (BDs) has been realized. It has two objective lenses arranged tangentially. Although one of the objective lenses, BD objective lens, does not follow the line that passes thorough the center of the spindle motor, stable tracking-error detection has been achieved by enhancing a one-beam method. This pickup has a beam shaper which changes a divergent angle of light with high magnification. Although beam shapers are sensitive to a positional error, our pickup accomplished stable positioning by introducing a new structure.
Binding of anti‐DNA antibodies and inhibition of glomerulonephritis in MRL‐lpr/lpr mice by heparin (1990)

Heparin was found to inhibit the DNA binding of antibodies eluted from kidneys of both humans and MRL-lpr/lpr mice with systemic lupus erythematosus. Treatment of MRL-lpr/lpr mice with low doses of heparin significantly inhibited renal damage. These results suggest that low-dose heparin might be useful in preventing renal damage in patients with lupus nephritis.
Confirming the Functional Importance of a Protein–DNA Interaction (2012)

Identifying DNA-binding proteins that interact with a control region of interest has become quite straightforward. However, the functional relevance of a given protein–DNA interaction is difficult to establish. The hypothesis that an interaction is relevant can be tested by several different experiments, 12 of which are outlined in this article. It must be remembered that none of these experiments by itself is conclusive. The information gained from each approach is described and explanations are given for why each yields useful but inconclusive results. The approaches vary widely with respect to the amount of effort required and the quality of information obtained.
Increases in Circulating Level of Platelet-Activating Factor Lag behind Transient Neutropenia during Hemodialysis with Cuprophane Membranes (1991)

The significance of the level of circulating 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphorylcholine (C16-PAF, platelet-activating factor) in relation to transient neutropenia during hemodialysis with cuprophane membranes was examined. The neutrophil count was transiently and significantly decreased at 30 min after the start of hemodialysis, and it then gradually recovered during the period from 60 to 240 min after the start. Mirror image changes were observed in the circulating levels of C3a and C5a, suggesting that the decrease in the neutrophil count was triggered by activation of the complement factors. The circulating level of C16-PAF, although being similar to the basal level after 30 min of hemodialysis, was significantly increased after 60 and 120 min of hemodialysis. These data indicate that the increase in the circulating PAF level is not a direct cause of the transient decrease in the neutrophil count, but may be the result of activated neutrophils during hemodialysis with cuprophane membranes.
Multi-Waveform Space-Time Adaptive Processing (2017)

A new form of space-time adaptive processing (STAP) is presented that leverages additional training data obtained from waveform-diverse pulse compression filters possessing low cross-correlation with the primary waveform that is used for traditional airborne and spacebased ground moving target indication. In contrast to traditional training data in which clutter and targets are “focused” in range via pulse compression of the primary waveform, this new set of training data possesses a “smeared” range response that better approximates the identically distributed assumption made during sample covariance estimation. The Multi-Waveform STAP (MuW-STAP or simply μ-STAP) formulation is shown for both multiple-input multiple-output and single-input multiple-output configurations, with the former retaining the spatially-focused primary emission supplemented by lowpower secondary emissions that illuminate sidelobe clutter and the latter a special case of the former. In simulation, signal to interference plus noise ratio analysis reveals enhanced robustness to nonstationary interference compared to standard STAP training data.
ChemInform Abstract: Synthesis of Various 5‐Arylsubstituted Cytosines. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Identification of a Regulatory Segment of Poly(ADP-ribose) Glycohydrolase (2010)

Coordinate regulation of PARP-1 and -2 and PARG is required for cellular responses to genotoxic stress. While PARP-1 and -2 are regulated by DNA breaks and covalent modifications, mechanisms of PARG regulation are poorly understood. We report here discovery of a PARG regulatory segment far removed linearly from residues involved in catalysis. Expression and analysis of human PARG segments identified a minimal catalytically active C-terminal PARG (hPARG59) containing a 16-residue N-terminal mitochondrial targeting sequence (MTS). Deletion analysis and site-directed mutagenesis revealed that the MTS, specifically hydrophobic residues L473 and L474, was required for PARG activity. This region of PARG was termed the "regulatory segment/MTS" (REG/MTS). The overall alpha-helical composition of hPARG59, determined by circular dichroism (CD), was unaffected by mutation of the REG/MTS leucine residues, suggesting that activity loss was not due to incorrect protein folding. REG/MTS was predicted to be in a loop conformation because the CD spectra of mutant Delta1-16 lacking the REG/MTS showed a higher alpha-helical content than hPARG59, indicating a secondary structure other than alpha-helix for this segment. Deletion of the REG/MTS from full-length hPARG111 also resulted in a complete loss of activity, indicating that all PARG isoforms are subject to regulation at this site. The presence of the REG/MTS raises the possibility that PARG activity is regulated by interactions of PARP-1 and -2 and other proteins at this site, raises interesting questions concerning mitochondrial PARG because MTS residues are often removed after transport, and offers a potentially novel site for drug targeting of PARG.
A UNIFIED APPROACH TO REAL-TIME, MULTI-RESOLUTION, MULTI-BASELINE 2D VIEW SYNTHESIS AND 3D DEPTH ESTIMATION USING COMMODITY GRAPHICS HARDWARE (2004)

We present a new method for using commodity graphics hardware to achieve real-time, on-line, 2D view synthesis or 3D depth estimation from two or more calibrated cameras. Our method combines a 3D plane-sweeping approach with 2D multi-resolution color consistency tests. We project camera imagery onto each plane, compute measures of color consistency throughout the plane at multiple resolutions, and then choose the color or depth (corresponding plane) that is most consistent. The key to achieving real-time performance is our use of the advanced features included with recent commodity computer graphics hardware to implement the computations simultaneously (in parallel) across all reference image pixels on a plane. Our method is relatively simple to implement, and flexible in term of the number and placement of cameras. With two cameras and an NVIDIA GeForce4 graphics card we can achieve 50–70 M disparity evaluations per second, including image download and read-back overhead. This performance matches the fastest available commercial software-only implementation of correlation-based stereo algorithms, while freeing up the CPU for other uses.
Broad Based Tissue Uptake of Polycationic Near-Infrared Polymeric Nanoparticles in Living Mice (2012)

A near infrared (NIR) fluorescent polymeric nanoparticle, commercialized under the name X-Sight 761 (X761), was tested for compatibility with pre-clinical in vivo imaging applications. In one experiment, an optical clearance profile was obtained by performing whole animal fluorescence imaging over the course of 48 hours on mice injected intravenously with X761. In a second trial, a temporal biodistribution was assessed by conducting necropsy and ex vivo analysis of X761 tissue accumulation at selected time points over a 48 hours period after i.v. injection. Taken together, the data demonstrate a sustained distribution of X761 into all major tissues over the time course, with an extremely low net clearance from the animal. This unique behavior is attributed to cell uptake mediated by the polycationic surface of X761. These properties negate the use of X761 as a reporter within a classical targeted molecular probe construct, in which selective concentration at a target site and rapid clearance from background tissues are needed to develop contrast. Nevertheless, the brightness and stability of X761 is well suited for a range of other applications, ranging from broad based in vivo drug delivery to in vitro fluorescence assays.
Characterization of a novel positive allosteric modulator of the α1A-Adrenergic receptor (2022)

α<sub>1</sub>-Adrenergic Receptors (ARs) are G-protein Coupled Receptors (GPCRs) that regulate the sympathetic nervous system via the binding and activation of norepinephrine (NE) and epinephrine (Epi). α<sub>1</sub>-ARs control various aspects of neurotransmission, cognition, cardiovascular functions as well as other organ systems. However, therapeutic drug development for these receptors, particularly agonists, has been stagnant due to unwanted effects on blood pressure regulation. We report the synthesis and characterization of the first positive allosteric modulator (PAM) for the α<sub>1</sub>-AR based upon the derivation of the α<sub>1A</sub>-AR selective imidazoline agonist, cirazoline. Compound 3 (Cmpd-3) binds the α<sub>1A</sub>-AR with high and low affinity sites (0.13pM; 54 ​nM) typical of GPCR agonists, and reverts to a single low affinity site of 100 ​nM upon the addition of GTP. Comparison of Cmpd-3 versus other orthosteric α<sub>1A</sub>-AR-selective imidazoline ligands reveal unique properties that are consistent with a type I PAM. Cmpd-3 is both conformationally and ligand-selective for the α<sub>1A</sub>-AR subtype. In competition binding studies, Cmpd-3 potentiates NE-binding at the α<sub>1A</sub>-AR only on the high affinity state of NE with no effect on the Epi-bound α<sub>1A</sub>-AR. Moreover, Cmpd-3 demonstrates signaling-bias and potentiates the NE-mediated cAMP response of the α<sub>1A</sub>-AR at nM concentrations with no effects on the NE-mediated inositol phosphate response. There are no effects of Cmpd-3 on the signaling at the α<sub>1B</sub>- or α<sub>1D</sub>-AR subtypes. Cmpd-3 displays characteristics of a pure PAM with no intrinsic agonist properties. Specific derivation of Cmpd-3 at the R1 <i>ortho</i>-position recapitulated PAM characteristics. Our results characterize the first PAM for the α<sub>1</sub>-AR and holds promise for a first-in-class therapeutic to treat various diseases without the side effect of increasing blood pressure intrinsic to classical orthosteric agonists.
Validating Identity via Internet (2005)

Verification of identity is very important in Internet,according to the characteristic of highefficient electronic information exchange In this paper we propose a method to link all kinds of identity data, and different levels of validation services can be given according to registration level Also exception and realization problems are discussed here
Cost-effective Approaches for in vitro mass Propagation of Rauwolfia serpentina Benth. Ex Kurz. (2007)

The present study describes a highly efficient and a very cost effective micropropagation protocol for exsitu conservation of an important medicinal plant, Rauwolfia serpentina using glass beads as support matrix in liquid culture medium and as a potential alternative to agar and market grade sugar as carbon source. Glass beads can replace the conventionally used gelling agent agar without compromising the quality of the in vitro regenerated shoots/plantlets of R. serpentina. This practice could be helpful in achieving more than 95% reduction in cost media for the production of single regenerated shoot, moreover, the glass beads can be reused for indefinite time after proper acid wash.
Surgical Exposure with Minimally Invasive Cranial Exposures (2023)

Objectives: Minimally invasive surgical approaches for supratentorial and infratentorial pathologies have drawn interest due to the lower impact and consequent faster recovery. The objective of this study is to determine the average surgical exposure achieved with the mini-pterional, supraorbital (eyebrow), interhemispheric and retrosigmoid approaches using craniometric analysis based on neuroimaging, accounting for the differential thickness of the bone in each region and the approach corridor it affords at target.
Inducing Optimal Ripening Capacity of 1-MCP-treated `Bartlett' Pears after Regular Air or Controlled Atmosphere Storage (2004)

`Bartlett' pears were treated with 300 nL·L -1 1-MCP at 20°C for 24 h shortly after harvest, and were stored at -1 °C in either regular atmosphere (RA) or controlled atmosphere (CA: 1.5 kPa O 2 / 0.5 kPa CO 2 ). After 2 and 4 months of RA storage, or 4 months of CA storage, fruit were pre-conditioned at 10 °C, 15 °C or 20 °C for 5, 10, or 20 days, respectively. Pre-conditioned fruit were then held at 20 °C for 14 days to simulate marketing conditions. Flesh firmness (FF) and extractable juice (EJ) were monitored during the marketing period. The optimal stage of ripeness for `Bartlett' pears was defined to be when FF decreases to 27 N and EJ decreases to 55 mL/100 g. The proper pre-conditioning combinations of temperature and duration were 15 °C or 20 °C for 10 d or 10 °C for 20 d if the fruit had been stored in RA for 2 months, 10 °C or 15 °C for 5 d if the fruit had been in RA for 4 months, and 20 °C for 10 d or 10°C for 20 d if the fruit had been in CA for 4 months, for which combinations the fruit ripened within a week and maintained quality for 14 days at 20 °C. The treatment combinations of lower temperature and/or shorter duration times in pre-conditioning delayed the ripening response of the fruit, and combinations of higher temperature and/or longer duration times in pre-conditioning resulted in a shorter marketing life because of senescence breakdown, in comparison the optimal combinations mentioned above. These results indicate that pre-conditioning regimes for 1-MCP treated `Bartlett' pears are storage atmosphere and time dependent. Generally, CA stored fruit needed more preconditioning (in terms of higher temperature and/or longer duration) than did RA stored fruit.
[In vitro susceptibility of pathogenic Nocardia to beta-lactam antibiotics, especially imipenem, a carbapenem antibiotic]. (1989)

In vitro antibacterial activity of 30 beta-lactam antibiotics including 2 beta-lactamase inhibitors (clavulanic acid and sulbactam) against 2 major pathogenic Nocardia, i.e. Nocardia asteroides group and Nocardia brasiliensis was studied. Among the antibiotics tested, a newly developed carbapenem antibiotic, imipenem (IPM), was found to be the most active, followed by oxacephem group antibiotic flomoxef (FMOX). IPM exhibited activity against only N. asteroides group (N. asteroides, Nocardia farcinica and Nocardia nova). On the other hand, FMOX showed activity against all pathogenic Nocardia tested. A 2- to 30-fold decreases in minimum inhibitory concentration (MIC) for N. asteroides, N. brasiliensis and N. farcinica was noted when antibiotics and beta-lactamase inhibitors were combined compared to antibiotics alone. Further combination and enzymatic studies indicated that all pathogenic Nocardia possess beta-lactamase except for a half of the strains of N. nova. These species' specific sensitivity patterns of pathogenic Nocardia are discussed in this paper with references to their taxonomic positions.