gebhart/patrepeval huggingface dataset:
Photonics-enabled wideband microwave burst detection (2018)

In this Letter, to the best of our knowledge, a novel wideband microwave burst detection system is realized by utilizing photonics-assisted wavelength and time division multiplexing, in conjunction with optical storage. Deploying a coherent electro-optical dual comb and a recirculating optical frequency shifter with ∼1.28 μs round-rip delay, the proof-of-concept experimental system demonstrates the interrogation of ∼1 μs radio frequency (RF) bursts with up to an 8 GHz bandwidth and arbitrary hopping pattern at 1 MHz resolution and a refresh rate of ∼60 kHz using an 80 MHz RF detection unit. The proposed system can be easily upgraded to higher bandwidths and longer burst time apertures with suitable hardware.
Preserving Arc Length in Texture Mapping (1992)

Conventional mappings from the texture plane to three-dimensional surfaces fail to maintain the arc length of the texture when it is mapped onto the surface. This leads to unnatural texture appearance. In addition, texture gradient information is distorted, leading to poor perception of depth. We have developed an efficient algorithm which warps the texture in the texture plane such that the arc length of the texture on the three-dimensional surface is approximately preserved everywhere on the surface. This leads to much more natural texture appearance and preserves texture gradient information. Texture images are preprocessed before the mapping from the texture plane to the three-dimensional surface so no additional run time overhead is incurred compared to conventional two-dimensional texture mapping methods.
Crystalline and Conductive Poly(3‐hexylthiophene) Fibers (2011)

Abstract Intrinsically conducting polymer fibers are prepared from P3HT by melt spinning. High crystallinity is achieved by drawing the fibers after the spinning process, applying a draw ratio of 1:2. DSC and XRD measurements confirm the continuous increase of crystalline phases with drawing. For comparison, poly(ethylene terephthalate) fibers are coated with P3HT and drawn as well. Again, the drawing of the coated fiber results in a significant increase in crystallinity of the P3HT coating. The high amount of crystalline phases is associated with a dramatic increase in conductivity (350 S · cm −1 ) after doping with FeCl 3 in nitromethane. magnified image
Optimization of Glaucoma Management During a Pandemic: Drive-Through IOP Checks (2021)

Purpose : In this pilot study, we compared the efficacy of drive-through intraocular pressure (IOP) checks in combination with E-health visits to E-health visits alone in the management of glaucoma patients during the COVID-19 pandemic. Methods : We performed a retrospective chart review for visits from April 2020 - November 2020 to compare subjects that received E-health visits (Group 1) versus subjects that received E-health visits with a drive-through IOP check (Group 2). Drive-through visits consisted of temperature screening with a non-contact infrared thermometer, near visual acuity check, and IOP measurements using a Tono-Pen XL Tonometer (Reichert, Depew, NY) followed by a video E-health visit with a glaucoma specialist. Group 1 patients only attended a video visit. We compared the proportion of interventions done at the visit as well as changes in visual acuity (VA) and IOP after the tele-visits between the 2 groups. The 4 types of interventions were: change in drop type, change in drop frequency, change in number of drops, and recommending surgical or laser intervention. Results : 28 subjects were included in our pilot study (mean age 74.9 +/- 3.8 years, 57.1% female). There was no significant difference in baseline characteristics between group 1 (n=15) and group 2 (n=13, Table 1). 6.7% of Group 1 patients had an intervention done compared to 38.5% of group 2 patients. Fisher exact probability testing showed a significant increase in the proportion of interventions done in group 2 subjects compared to group 1 subjects (p=.041), with the most common interventions being changing number of drops and drop frequency. There was no significant difference in changes in VA or IOP between the 2 groups (Table 1). Conclusions : Drive-through IOP checks in combination with virtual visits resulted in more interventions than virtual visits alone in the care of glaucoma patients during the COVID-19 pandemic. This novel healthcare modality can address the mismatch between capacity and demand for glaucoma care both during a pandemic and can further expand access to sub-specialized care.
Effects of cesium ion implantation on the mechanical and electrical properties of porous SiCOH low-k dielectrics (2017)

In this work, the authors report an investigation of the effects of cesium (Cs) ion implantation on both porogen-embedded and ultraviolet (UV)-cured (porous) SiCOH films. For porogen-embedded SiCOH, it was found that Cs ion implantation can greatly improve the elastic modulus. It can also increase the time-zero dielectric breakdown (TZDB) strength. It also leads to an increase in the k-value for medium and high Cs doses, but for low Cs doses, the k-value decreased compared with its pristine counterpart. For UV-cured SiCOH, it was found that Cs-ion implantation does not improve the elastic modulus. It also leads to lower TZDB field strength and much higher k-values than its pristine counterpart. These effects can be understood by examining the changes in chemical bonds. This treatment is shown to have the potential to help solve the problem of the demand for lower k-values and the concomitant weak mechanical strength of SiCOH.
Bestimmung der NFAT-regulierten Gen-Expression im peripheren Blut lebertransplantierter Patienten (2010)

Einleitung: Bei Herz- und Nierentransplantierten konnte gezeigt werden, dass die Expression von NFAT (nuclear factor of activated T cells) regulierten Genen (z.B. Interleukin-2, TNF-alpha, Interferon-gamma und GMCSF) Ciclosporin (CsA) Spiegel abhängig ist. Die Genexpression von NFAT regulierten Genen korrelierte invers mit dem CsA Spiegel. Darüberhinaus wurde ein Zusammenhang zwischen dem Auftreten maligner oder infektiöser Komplikationen sowie dem Auftreten von Abstoßungsreaktionen und der Genexpression von NFAT regulierten Genen gefunden.
Effects of Obestatin on Energy Balance and Growth Hormone Secretion in Rodents (2006)

Ghrelin stimulates food intake and adiposity and thereby increases body weight (BW) in rodents after central as well as peripheral administration. Recently, it was discovered that the gene precursor of ghrelin encoded another secreted and bioactive peptide named obestatin. First reports appeared to demonstrate that this peptide requires an amidation for its biological activity and acts through the orphan receptor, GPR-39. Obestatin was shown to have actions opposite to ghrelin on food intake, BW, and gastric emptying. In the present study, we failed to observe any effect of obestatin on food intake, BW, body composition, energy expenditure, locomotor activity, respiratory quotient, or hypothalamic neuropeptides involved in energy balance regulation. In agreement with the first report, we were unable to find any effect of obestatin on GH secretion in vivo. Moreover, we were unable to find mRNA expression of GPR-39, the putative obestatin receptor, in the hypothalamus of rats. Therefore, the results presented here do not support a role of the obestatin/GPR-39 system in the regulation of energy balance.
Predicting Cosmic Ray-Induced Failures in Silicon Carbide Power Devices (2019)

A phenomenological expression for predicting atmospheric neutron-induced failure rates in silicon carbide (SiC) power devices is presented. This expression that relates the local electric field to terrestrial neutron-induced failure rate is derived using empirical data that show commonalities between failures of different SiC power devices under this type of radiation. We also present a physics-based approach that provides a similar functional form for predicting these failure rates. The proposed closed-form expression is then used to demonstrate the use of this model in predicting failure rates in a hypothetical silicon carbide power device modeled using a technology computer-aided design tool.
Optimized attenuated interaction: Enabling stochastic Bethe–Salpeter spectra for large systems (2023)

We develop an improved stochastic formalism for the Bethe-Salpeter equation (BSE), based on an exact separation of the effective-interaction W into two parts, W = (W - vW) + vW, where the latter is formally any translationally invariant interaction, vW(r - r'). When optimizing the fit of the exchange kernel vW to W, using a stochastic sampling W, the difference W - vW becomes quite small. Then, in the main BSE routine, this small difference is stochastically sampled. The number of stochastic samples needed for an accurate spectrum is then largely independent of system size. While the method is formally cubic in scaling, the scaling prefactor is small due to the constant number of stochastic orbitals needed for sampling W.
Design Rules: A Net and Archimedean Polyhedra Score Big for Self‐Assembly (2012)

Caged: Taking its origin in recent work by Ward and co-workers, an overview is given on the synthesis of Archimedean and Platonic bodies (see picture) by different approaches, such as hydrogen-bonded self-assembly and coordination chemistry.
Misincorporation Proton‐Alkyl Exchange (MPAX): Engineering Cysteine Probes into Proteins (2005)

This unit describes a rapid and efficient method to screen a polypeptide for amino acid residues that contribute to protein-protein interaction interfaces. Cysteine residues are introduced as positional probes in a protein at random by co-expression in bacteria with specific cysteine misincorporator tRNAs. The protein is then purified as an ensemble of polypeptides containing cysteine at low frequency, at different positions in each molecule. The ability of the native protein structure to protect different cysteine residues from chemical modification by iodoacetamide is determined to obtain a protein surface map that reveals candidate surface residues that are likely to be important for protein-protein interaction. Cysteine mutants with altered ligand binding can also be selected simultaneously by affinity chromatography.
[Serologic properties of antigens HLA-A, B and C]. (1981)

Human leukocyte antigens (HLA) are transmembrane bicatenar glycoproteins; their heavy chain is coded by chromosome 6 and carries allotypic determinants. These molecules are present in nearly every cell, tissue and biologic fluid. Their congenital absence from fibroblasts is associated with progeria, while their absence from lymphocytes is associated with immunodeficiency. HLA antigens are usually studied microlymphocytotoxicity tests. The numerous cross-reactions encountered make the interpretation of results quite difficult. To clearly understand these reactions a complex-complex model is mandatory. The antigen, the HLA molecule, is complex since it carries many antigenic determinants; some of them are private ("subtypic"), while others are public ("subtypic"). Anti-HLA antibodies are also complex since they are heterogeneous, reacting with variable affinity with different antigenic determinants. The in vitro cross-reactions represent a partial explanation for varying cross-immunogenicity in vivo.
A technique for defect investigation in pulse-controlled motors through partial discharge measurements (2005)

This paper presents a procedure for the investigation of partial discharge (PD) sources in PWM-controlled motors, based on off-line measurements under bipolar squarewaves. PD measurements were carried out on three-phase motors with open-star windings and different configurations, e.g., one phase supplied while the other two were grounded, two phases connected in series, grounding the motor frame. The voltage waveforms generated by a power supply and applied to motor windings was recorded at the winding terminals, for each test configuration. These measurements allowed to highlight winding positions where insulation can be overstressed by uneven voltage distribution, as occurs on motors in service. By comparing partial discharge measurement patterns along windings and under different test configurations, a qualitative evaluation of the location of partial discharge sources inside the tested motors was carried out.
High Content Image Based Analysis Identifies Cell Cycle Inhibitors as Regulators of Ebola Virus Infection (2012)

Viruses modulate a number of host biological responses including the cell cycle to favor their replication. In this study, we developed a high-content imaging (HCI) assay to measure DNA content and identify different phases of the cell cycle. We then investigated the potential effects of cell cycle arrest on Ebola virus (EBOV) infection. Cells arrested in G1 phase by serum starvation or G1/S phase using aphidicolin or G2/M phase using nocodazole showed much reduced EBOV infection compared to the untreated control. Release of cells from serum starvation or aphidicolin block resulted in a time-dependent increase in the percentage of EBOV infected cells. The effect of EBOV infection on cell cycle progression was found to be cell-type dependent. Infection of asynchronous MCF-10A cells with EBOV resulted in a reduced number of cells in G2/M phase with concomitant increase of cells in G1 phase. However, these effects were not observed in HeLa or A549 cells. Together, our studies suggest that EBOV requires actively proliferating cells for efficient replication. Furthermore, multiplexing of HCI based assays to detect viral infection, cell cycle status and other phenotypic changes in a single cell population will provide useful information during screening campaigns using siRNA and small molecule therapeutics.
Electrochemical Sample Pretreatment Coupled On-Line with ICP-MS:  Analysis of Uranium Using an Anodically Conditioned Glassy Carbon Working Electrode (1998)

Uranium may be accumulated at an anodized glassy carbon (GC) electrode at −0.15 V and stripped at +1.15 V, allowing electrochemical preconcentration and matrix elimination on-line with ICP-MS detection. Analyte levels ranging from 20 μg/L to subnanogram per liter were determined in matrix-free standards with good linearity and precision. Detection limits (3sy/x/slope) determined from standard addition plots were 0.12 ng/L with 10-min accumulation time, permitting the minor isotopes of uranium to be determined with good precision at total uranium concentrations as low as 5.0 μg/L. High levels of salt matrix moderately suppressed uranium deposition efficiency, and therefore stripping peak height, but could be compensated for by extended accumulation times. Matrix elimination of up to 20 000 mg/L Na was complete with just a 90-s cell washout time. Uranium was quantified in a certified seawater matrix, NASS-4 (certified uranium level 2.68 ± 0.12 μg/L), at several levels of dilution: recoveries ranged from 100.4 to 119.4% and all agreed with the true value within 95% CL. Thorium showed a similar affinity for anodized GC, and simultaneous measurement of thorium and uranium was demonstrated.
Evaluation of a Centyrin-Based Near-Infrared Probe for Fluorescence-Guided Surgery of Epidermal Growth Factor Receptor Positive Tumors (2017)

Tumor-targeted near-infrared fluorescent dyes have the potential to improve cancer surgery by enabling surgeons to locate and resect more malignant lesions where good visualization tools are required to ensure complete removal of malignant tissue. Although the tumor-targeted fluorescent dyes used in humans to date have been either small organic molecules or high molecular weight antibodies, low molecular weight protein scaffolds have attracted significant attention because they penetrate solid tumors almost as efficiently as small molecules, but can be infinitely mutated to bind almost any antigen. Here we describe the use of a 10 kDa protein scaffold, a Centyrin, to target a near-infrared fluorescent dye to tumors that overexpress the epidermal growth factor receptor (EGFR) for fluorescence-guided surgery (FGS). We have developed and optimized the dose and time required for imaging small tumor burdens with minimal background fluorescence in real-time fluorescence-guided surgery of EGFR-expressing tumor xenografts in murine models. We demonstrate that the Centyrin-near-infrared dye conjugate (CNDC) binds selectively to human EGFR<sup>+</sup> cancer cells with an EC<sub>50</sub> of 2 nM, localizes to EGFR<sup>+</sup> tumor xenografts in athymic nude mice and that uptake of the dye in xenografts is significantly reduced when EGFR are blocked by preinjection of excess unlabeled Centyrin. Taken together, these data suggest that CNDCs can be used for intraoperative identification and surgical removal of EGFR-expressing lesions and that Centyrins targeted to other tumor-specific antigens should prove similarly useful in fluorescence guided surgery of cancer. In addition, we demonstrate that the CNDC is detected in the NIR region of the spectrum and can be utilized for fluorescence-guided surgery (FGS). In addition, we propose that with its eventual complete clearance from EGFR-negative tissues and its quantitative retention in the tumor mass for >24 h, a Centyrin-targeted NIR dye should provide excellent tumor contrast when injected at least 6-8 h before initiation of cancer surgery in human patients.
Beneficial Hemodynamic and Renal Effects of Adrenomedullin in an Ovine Model of Heart Failure (1997)

Adrenomedullin reduced ventricular preload and afterload and improved cardiac output in sheep with congestive heart failure. Despite the clear fall in arterial pressure, adrenomedullin increased creatinine clearance and sodium excretion and maintained urine output. These results imply an important pathophysiological role for adrenomedullin in the regulation of pressure and volume in heart failure and raise the possibility of a new therapeutic approach to this disease.
Characterization of Dual-Acting A3 Adenosine Receptor Positive Allosteric Modulators That Preferentially Enhance Adenosine-Induced Gαi3 and GαoA Isoprotein Activation (2022)

The A<sub>3</sub> adenosine receptor (A<sub>3</sub>AR) is a promising therapeutic target for inflammatory diseases, cancer, and chronic neuropathic pain, with agonists already in advanced clinical trials. Here we report an in-depth comparison of the pharmacological properties and structure-activity relationships of existing and expanded compound libraries of 2-substituted 1<i>H</i>-imidazo[4,5-<i>c</i>]quinolin-4-amine and 4-amino-substituted quinoline derivatives that function as A<sub>3</sub>AR positive allosteric modulators (PAMs). We also show that our lead compound from each series enhances adenosine-induced A<sub>3</sub>AR signaling preferentially toward activation of Gα<sub>i3</sub> and Gα<sub>oA</sub> isoproteins, which are coexpressed with the A<sub>3</sub>AR in immune cells and spinal cord neurons. Finally, utilizing an extracellular/intracellular chimeric A<sub>3</sub>AR approach composed of sequences from a responding (human) and a nonresponding (mouse) species, we provide evidence in support of the idea that the imidazoquinolin-4-amine class of PAMs variably interacts dually with the orthosteric ligand binding site as well as with a separate allosteric site located within the inner/intracellular regions of the receptor. This study has advanced both structural and pharmacological understanding of these two classes of A<sub>3</sub>AR PAMs, which includes leads for future pharmaceutical development.
Performance of Mobile Haptic Interfaces (2006)

One of most interesting aspects in haptic research deals with the extension of application workspace, thus allowing haptic simulation within large virtual environments. Several devices have been realized that allow this kind of interaction, in particular our interest focuses on mobile haptic interfaces, realized by combining classic grounded haptic devices with mobile platforms. While grounded haptic interfaces feature spatial limitations due to manipulator dimensions, mobile haptic interfaces are characterized by dynamical limitations due to performance of employed devices. In this paper we introduce an experimental analysis to evaluate performance of mobile haptic interface from a transparency standpoint. Moreover, some basic guidelines are presented to enhance MHI performance by setting the controller depending on technical parameters characterizing used devices.
Inhibition of Phosphatidylinositol 3-Kinase Activity by Adenovirus-mediated Gene Transfer and Its Effect on Insulin Action (1998)

Phosphatidylinositol 3-kinase (PI 3-K) is implicated in cellular events including glucose transport, glycogen synthesis, and protein synthesis. It is activated in insulin-stimulated cells by binding of the Src homology 2 (SH2) domains in its 85-kDa regulatory subunit to insulin receptor substrate-1 (IRS-1), and, others. We have previously shown that IRS-1-associated PI 3-kinase activity is not essential for insulin-stimulated glucose transport in 3T3-L1 adipocytes, and that alternate pathways exist in these cells. We now show that adenovirus-mediated overexpression of the p85N-SH2 domain in these cells behaves in a dominant-negative manner, interfering with complex formation between endogenous PI 3-K and its SH2 binding targets. This not only inhibited insulin-stimulated IRS-1-associated PI 3-kinase activity, but also completely blocked anti-phosphotyrosine-associated PI 3-kinase activity, which would include the non-IRS-1-associated activity. This resulted in inhibition of insulin-stimulated glucose transport, glycogen synthase activity and DNA synthesis. Further, Ser/Thr phosphorylation of downstream molecules Akt and p70 S6 kinase was inhibited. However, co-expression of a membrane-targeted p110(C) with the p85N-SH2 protein rescued glucose transport, supporting our argument that the p85N-SH2 protein specifically blocks insulin-mediated PI 3-kinase activity, and, that the signaling pathways downstream of PI 3-kinase are intact. Unexpectedly, GTP-bound Ras was elevated in the basal state. Since p85 is known to interact with GTPase-activating protein in 3T3-L1 adipocytes, the overexpressed p85N-SH2 peptide could titrate out cellular GTPase-activating protein by direct association, such that it is unavailable to hydrolyze GTP-bound Ras. However, insulin-induced mitogen-activated protein kinase phosphorylation was inhibited. Thus, PI 3-kinase may be required for this action at a step independent of and downstream of Ras. We conclude that, in 3T3-L1 adipocytes, non-IRS-1-associated PI 3-kinase activity is crucial for insulin's metabolic signaling, and that overexpressed p85N-SH2 protein inhibits a variety of insulin's ultimate biological effects.
Recombining light of the VLTI at 10 microns by densifying the images (2004)

APreS-MIDI (APerture Synthesis in the MID-Infrared) instrument function is to recombine 4 telescope beams of the VLTI. Interference fringes are sampled in the pupil plane. The optical principle uses "image densification". It is perfectly adapted for reconstructing images by aperture synthesis at 10mm. This principle could be used for building a new generation 10mm instrument, but instead of making a totally new instrument, we propose the design of an optical module that can supply the current MIDI-VLTI instrument with 4 beams.
Gas Chromatographic Residue Patterns of Toxaphene in Fish Samples from the Great Lakes and from Rivers of the Southeastern United States (1987)

Residues of environmentally derived toxaphene were determined in fish samples from the Great Lakes and from rivers of the southeastern United States. These analyses were performed by fused silica capillary gas chromatography with electron capture detection. Data reduction and compilation were performed using an “in-house” developed data base system. In an effort to more clearly delineate the similarity of environmentally derived toxaphene residues to technical toxaphene, SIMCA, a principal components pattern recognition technique, was used to analyze sample residues. The results of these analyses are discussed.