gebhart/patrepeval huggingface dataset:
A Facile Synthesis of ZnCo2O4 Nanocluster Particles and the Performance as Anode Materials for Lithium Ion Batteries (2016)

ZnCo2O4 nanocluster particles (NCPs) were prepared through a designed hydrothermal method, with the assistance of a surfactant, sodium dodecyl benzene sulfonate. The crystalline structure and surface morphology of ZnCo2O4 were investigated by XRD, XPS, SEM, TEM, and BET analyses. The results of SEM and TEM suggest a clear nanocluster particle structure of cubic ZnCo2O4 (~100 nm in diameter), which consists of aggregated primary nanoparticles (~10 nm in diameter), is achieved. The electrochemical behavior of synthesized ZnCo2O4 NCPs was investigated by galvanostatic discharge/charge measurements and cyclic voltammetry. The ZnCo2O4 NCPs exhibit a high reversible capacity of 700 mAh g−1 over 100 cycles under a current density of 100 mA g−1 with an excellent coulombic efficiency of 98.9% and a considerable cycling stability. This work demonstrates a facile technique designed to synthesize ZnCo2O4 NCPs which show great potential as anode materials for lithium ion batteries.
Graph Learning from Data under Structural and Laplacian Constraints (2016)

Graphs are fundamental mathematical structures used in various fields to represent data, signals and processes. In this paper, we propose a novel framework for learning/estimating graphs from data. The proposed framework includes (i) formulation of various graph learning problems, (ii) their probabilistic interpretations and (iii) associated algorithms. Specifically, graph learning problems are posed as estimation of graph Laplacian matrices from some observed data under given structural constraints (e.g., graph connectivity and sparsity level). From a probabilistic perspective, the problems of interest correspond to maximum a posteriori (MAP) parameter estimation of Gaussian-Markov random field (GMRF) models, whose precision (inverse covariance) is a graph Laplacian matrix. For the proposed graph learning problems, specialized algorithms are developed by incorporating the graph Laplacian and structural constraints. The experimental results demonstrate that the proposed algorithms outperform the current state-of-the-art methods in terms of accuracy and computational efficiency.
Carbon nanobelts as a novel sensing platform for fluorescence-enhanced DNA detection (2014)

The present communication demonstrates for the first time that carbon nanobelts (CNBs) were facilely synthesized on a large scale via pyrolysis of a 1,8-diaminonaphthalene (DAN)-NiCl2·6H2O mixture under Ar followed by acid leaching. We further demonstrate that such CNBs can be used as a novel effective fluorescent sensing platform for DNA. This sensing platform exhibits high selectivity and sensitivity with a detection limit of 5 nM.
Relative effects of VEGF‐A and VEGF‐C on endothelial cell proliferation, migration and PAF synthesis: Role of neuropilin‐1 (2002)

Vascular endothelial growth factor (VEGF-A) is an inducer of endothelial cell (EC) proliferation, migration, and synthesis of inflammatory agents such as platelet-activating factor (PAF). Recently, neuropilin-1 (NRP-1) has been described as a coreceptor of KDR which potentiates VEGF-A activity. However, the role of NRP-1 in numerous VEGF-A activities remains unclear. To assess the contribution of NRP-1 to VEGF-A mediated EC proliferation, migration, and PAF synthesis, we used porcine aortic EC (PAEC) recombinantly expressing Flt-1, NRP-1, KDR or KDR and NRP-1. Cells were stimulated with VEGF-A, which binds to Flt-1, KDR and NRP-1, and VEGF-C, which binds to KDR only. VEGF-A was 12.4-fold more potent than VEGF-C in inducing KDR phosphorylation in PAEC-KDR. VEGF-A and VEGF-C showed similar potency to mediate PAEC-KDR proliferation, migration, and PAF synthesis. On PAEC-KDR/NRP-1, VEGF-A was 28.6-fold more potent than VEGF-C in inducing KDR phosphorylation and PAEC-KDR/NRP-1 proliferation (1.3-fold), migration (1.7-fold), and PAF synthesis (4.6-fold). These results suggest that cooperative binding of VEGF-A to KDR and NRP-1 enhances KDR phosphorylation and its biological activities. Similar results were obtained with bovine aortic EC that endogenously express both KDR and NRP-1 receptors. In contrast, stimulation of PAEC-Flt-1 and PAEC-NRP-1 with VEGF-A or VEGF-C did not induce proliferation, migration, or PAF synthesis. In conclusion, the presence of NRP-1 on EC preferentially increases KDR activation by VEGF-A as well as KDR-mediated biological activities, and may elicit novel intracellular events. On the other hand, VEGF-A and VEGF-C have equipotent biological activities on EC in absence of NRP-1.
Freeform off-axis optical system with multiple sets of performance integrations (2019)

Freeform optical surfaces make it possible and feasible to design systems with novel functions. In this Letter, a new type of freeform system with multiple sets of performance integrations is proposed, for the first time to the best of our knowledge. The system can operate at different optical parameters for different imaging demands. A movable aperture stop is used in the system for switching between the working areas suited for different sets of optical parameters. A construction method for integrated freeform surfaces is proposed herein, which considers multiple object-image relationships simultaneously. By this method, three integrated freeform systems were designed with different novel functions. This Letter adds more variety to the design of freeform off-axis systems.
Intravaginal Gel for Staging of Female Pelvic Cancers—Preliminary Report of Safety, Distention, and Gel-Mucosal Contrast During Magnetic Resonance Examination (2012)

To more fully outline cervical and vaginal contours and distend the vagina, we have filled the vagina with sterile water-based gel before the magnetic resonance (MR) examination. The technique is similar to that used for defecating MR proctography and other MR examinations, but has not been well described for MR imaging of female pelvic cancer. We present our preliminary clinical experience, including a review of safety imaging characteristics and maintenance of the distention during the examination.
N-Acyl Homoserine Lactone Analog Modulators of thePseudomonas aeruginosaRhll Quorum Sensing Signal Synthase (2019)

Virulence in the Gram-negative pathogen Pseudomonas aeruginosa relies in part on the efficient functioning of two LuxI/R dependent quorum sensing (QS) cascades, namely, the LasI/R and RhlI/R systems that generate and respond to N-(3-oxo)-dodecanoyl-l-homoserine lactone and N-butyryl-l-homoserine lactone, respectively. The two acyl homoserine lactone (AHL) synthases, LasI and RhlI, use 3-oxododecanoyl-ACP and butyryl-ACP, respectively, as the acyl-substrates to generate the corresponding autoinducer signals for the bacterium. Although AHL synthases represent excellent targets for developing QS modulators in P. aeruginosa, and in other related bacteria, the identification of potent and signal synthase specific inhibitors has represented a significant technical challenge. In the current study, we sought to test the utility of AHL analogs as potential modulators of an AHL synthase and selected RhlI in P. aeruginosa as an initial target. We systematically varied the chemical functionalities of the AHL headgroup, acyl chain tail, and head-to-tail linkage to construct a small library of signal analogs and evaluated them for RhlI modulatory activity. Although the native N-butyryl-l-homoserine lactone did not inhibit RhlI, we discovered that several of our long-chain, unsubstituted acyl-d-homoserine lactones and acyl-d-homocysteine thiolactones inhibited while a few of the 3-oxoacyl-chain counterparts activated the enzyme. Additional mechanistic investigations with acyl-substrate analogs and docking experiments with AHL analogs revealed two distinct inhibitor and activator binding pockets in the enzyme. This study provides the first evidence of the yet untapped potential of AHL analogs as signal synthase modulators of QS pathways.
Differentiation of Bifidobacterium longum subspecies longum and infantis by quantitative PCR using functional gene targets (2017)

Our qPCR method differentiates <i>B. longum</i> subspecies <i>longum</i> and <i>infantis</i> using characteristic functional genes. It can be used as an identification aid for isolates of bifidobacteria, as well as in determining prevalence and abundance of the subspecies in feces. The method should thus be useful in ecological studies of the infant gut microbiota during early life where an understanding of the ecology of bifidobacterial species may be important in developing interventions to promote infant health.
Telebiometric Authentication Objects (2014)

This paper describes a method for achieving strong, low cost multi-factor authentication on the Internet of Things that is convenient for people to use. Authentication relies on tagged objects functioning with biometric sensors connected to a telecommunications network. Access control systems based on these telebiometric authentication objects do not require users to carry individually assigned security tokens, remember complex passwords, or possess and manage cryptographic keys and public key certificates. Authentication decisions are based on previously registered person-object associations created using cryptographic techniques that bind the biometric reference template of an individual to one or more tagged objects. Trusted person-object bindings are formed using digital signature or signcryption techniques based on certificates in a public key infrastructure. Cryptographic message syntax is defined that can be used to provide data integrity and origin authenticity services for telebiometric authentication objects and messages, and to protect the confidentiality of personally identifiable and other sensitive information.
A More Effective C_{EFF} (2005)

Precise chip-level timing requires careful modeling of the interaction between logic drivers and interconnect. Existing static-timing analysis methodologies generate models for drivers with lumped capacitive loads. This necessitates the translation of the actual loading and interconnect parasitics into a single effective capacitance. Existing approaches to perform that translation are either iterative in nature or involve iterative procedure to solve non-closed form equations and thus costly in CPU time. This paper presents a new accurate and simple closed form approach to deal with effective capacitance.
SyNAPSE: Jun Sawada (2013)

In this extended abstract IBM researchers, with collaborators from a number of leading universities, repot their work on a cognitive computing project called Systems of Neuromorphic Adaptive Plastic Scalable Electronics (SyNAPSE) supported by Defense Advanced Research Programs Agency (DARPA). It combines the principles of nanoscience, neuroscience and supercomputing to simulate and emulate the brain's abilities for sensation, perception, action, interaction and cognition while rivaling its low power consumption and compact size. The aggressive end goal of DARPA's SyNPASE project is to develop an electronic neurosynaptic machine with 1014 synapses, simulating neurons firing at 10Hz real-time, and consuming 1kW of energy.
Transformation of Nickelalactones to Methyl Acrylate: On the Way to a Catalytic Conversion of Carbon Dioxide (2011)

Mu-nick: The methyl iodide-mediated ring opening of nickelalactones, which can be formed by oxidative coupling of carbon dioxide and ethylene at Ni0 complexes, induces β-H elimination, producing methyl acrylate in yields of up to 56 %. This reaction is found to be very sensitive to the ligands coordinated to the central nickel atom. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Computed axial lithography: volumetric 3D printing of arbitrary geometries (Conference Presentation) (2018)

Lower-dimensional photopolymerization based additive manufacturing techniques have several drawbacks that currently limit the applicability and scope of 3D printing, including: topological constraints, the requirement for numerous complex support structures that later need to be removed, long print times for complex geometries, relative motion between the liquid resin and printed part, as well as debilitating mechanical weakness and anisotropy resulting from the inherently layered structure of the parts. We propose and demonstrate a novel volumetric 3D printing technique based on one of the most ubiquitous computational imaging methods in the field: computed axial tomography. Computed axial lithography (CAL) is a vat photopolymerization technique that exposes the entire resin volume by projecting images from a multiplicity of angles. The technique is a physical implementation of the filtered back projection algorithm for tomographic reconstruction. We use constrained non-convex optimization in order to generate images that are projected into the resin in order to sculpt a 3-dimensional energy dose that cures the desired arbitrary geometry. This eliminates the requirement for supports and enables complex and nested structures that were previously challenging or impossible to print. Further, the process is layer-less and does not involve any relative motion between the resin and the printed part, which has positive implications for mechanically isotropic part strength. We demonstrate support-less printing of complex geometries containing 10^8-10^9 voxels in 2-4 minutes, orders of magnitude faster than comparable techniques.
Geometries of the Living (2016)

Mr Administrator, Professors, My dear colleagues, My Friends, In 1984, in Jacques Glowinski’s laboratory, we witnessed the fact that the form and polarity of cerebral neurons cultivated in contact with non-neuronal cells – astrocytes – vary according to the topological origin of these two cell populations. We could have chosen to study astrocyte heterogeneity, which was a novel idea, but I was mainly struck by the link between form and position that this observation suggested. Having attende...
Contraceptive Vaccines Based on the Zona Pellucida Glycoproteins for Dogs and Other Wildlife Population Management (2011)

Zona pellucida (ZP) glycoproteins, by virtue of their critical role in fertilization, have been proposed as candidate antigens for the development of contraceptive vaccines. In this review, the potential of a ZP-based contraceptive vaccine for the management of wildlife population, with special reference to street dogs, is discussed. Immunization of various animal species, including female dogs, with native porcine ZP led to inhibition of fertility, which was associated with the ovarian dysfunction. Immunization of female dogs with Escherichia coli-expressed recombinant dog ZP glycoprotein-3 (ZP3) either coupled to diphtheria toxoid or expressed as fusion protein with 'promiscuous' T non-B-cell epitope of tetanus toxoid also led to inhibition of fertility. To improve the contraceptive efficacy of ZP-based contraceptive vaccine, various groups are working on improving the immunogen, use of DNA vaccine as prime-boost strategy, and delivering the zona proteins/peptides presented on either virus-like particles or entrapped in microsphere. Host-specific live vectors such as ectromelia virus and cytomegalovirus have also been used to deliver mouse ZP3 in mice. Various studies show the enormous potential of the ZP-based vaccine for the management of wildlife population, where permanent sterilization may be desirable.
Drug/Lead Compound Hydroxymethylation as a Simple Approach to Enhance Pharmacodynamic and Pharmacokinetic Properties (2022)

Hydroxymethylation is a simple chemical reaction, in which the introduction of the hydroxymethyl group can lead to physical-chemical property changes and offer several therapeutic advantages, contributing to the improved biological activity of drugs. There are many examples in the literature of the pharmaceutical, pharmacokinetic, and pharmacodynamic benefits, which the hydroxymethyl group can confer to drugs, prodrugs, drug metabolites, and other therapeutic compounds. It is worth noting that this group can enhance the drug's interaction with the active site, and it can be employed as an intermediary in synthesizing other therapeutic agents. In addition, the hydroxymethyl derivative can result in more active compounds than the parent drug as well as increase the water solubility of poorly soluble drugs. Taking this into consideration, this review aims to discuss different applications of hydroxymethyl derived from biological agents and its influence on the pharmacological effects of drugs, prodrugs, active metabolites, and compounds of natural origin. Finally, we report a successful compound synthesized by our research group and used for the treatment of neglected diseases, which is created from the hydroxymethylation of its parent drug.
Synthesis and Biological Evaluation of Purealin and Analogues as Cytoplasmic Dynein Heavy Chain Inhibitors (2006)

Cytoplasmic dynein plays important roles in membrane transport, mitosis, and other cellular processes. A few small-molecule inhibitors of cytoplasmic dynein have been identified. We report here the first synthesis of purealin, a natural product isolated from the sea sponge Psammaplysilla purea, which is known to inhibit axonemal dynein. Also described are the first syntheses, by modular amide coupling reactions, of the natural product purealidin A (a component of purealin) and a small library of analogues. The library was examined for inhibition of cytoplasmic dynein heavy chain and cell growth. The compounds showed effective antiproliferative activity against a mouse leukemia cell line but selective activities against human carcinoma cell lines. Purealin and some of the analogues inhibited the microtubule-stimulated ATPase activity of recombinant cytoplasmic dynein heavy chain motor domain. The inhibitory effect of purealin was concentration dependent and uncompetitive, supporting the hypothesis that it does not compete with the binding of ATP.
[OP.2D.05] RELATIONSHIP OF OXIDATIVE STRESS WITH CARDIAC HYPERTROPHY IN HYPERTENSIVE PATIENTS (2016)

Objective: Left ventricular hypertrophy is common in hypertensive patients. In these subjects increased oxidative stress has been observed. Our aim was to evaluate the association of biomarkers of both oxidative stress and inflammation with markers of cardiovascular damage in a large group of hypertensives with different stages of renal function. Design and method: In 517 hypertensives we analyzed left ventricular mass indexed for body surface area, and we assayed plasma levels of 8-isoprostaglandin F2α and high sensitivity C reactive protein. Results: Multivariate analysis carried out considering left ventricular mass as dependent variable, and including 8-isoprostaglandin F2α, high sensitivity C reactive protein, age, sex, body mass index, estimated glomerular filtration rate, serum glucose, (log)triglycerides, hemoglobin, pulse pressure or systolic blood pressure, mean or diastolic blood pressure, and antihypertensive treatment showed that in hypertensives plasma levels of 8-isoprostaglandin F2α were correlated with left ventricular mass (β=0.269, p < 0.0001). The bivariate relationship of left ventricular mass with 8-isoprostaglandin F2α in hypertensives with estimated glomerular filtration rate higher and lower than 60 ml/min/1.73m2 was also calculated separately, demonstrating no significant differences in both correlations coefficients and slopes of the regression lines (r = 0.254, p < 0.001 and r = 0.226, p < 0.002; respectively). In the overall group, receiver operating characteristic curves showed that 8-isoprostaglandin F2α and high sensitivity C reactive protein were predictors of left ventricular hypertrophy, p < 0.0001. Conclusions: To the best of our knowledge, this is the first demonstration that in hypertensives oxidative stress is correlated to left ventricular hypertrophy independently of other confounding factors. Oxidative stress might participate in the development of hypertensive cardiac hypertrophy.
Multiplexed Point Spread Functions for Image Formation with Application to Large Area Sensing and Surveillance (2007)

The ability to form images without conventional lenses is of significant interest for a variety of imaging applications. One approach is to use a spatial light modulator as a programmable aperture that can be used to implement different types of transforms during the imaging process. In this paper, we discuss an approach for creating the image of a large scene by multiplexing smaller portions of the scene onto the same focal plane. This is achieved by interleaving multiple pupil functions in the same aperture, and directing each pupil function to “look” in multiple directions. Several frames are collected by sequencing different groups of pupil functions which are then decoded to reconstruct the full image. We will also address the implications of signal to noise ratio (SNR) on the image reconstruction process, and the trade between SNR and associated modulation transfer function (MTF).
Intraoperative optical coherence tomography using the RESCAN 700: preliminary results from the DISCOVER study (2014)

Significant integrative advances are needed for intraoperative optical coherence tomography (iOCT) to achieve widespread use across ophthalmic surgery. A surgeon feedback system that provides microscope integration, heads-up display and foot pedal control of the OCT scan location represents a major interval advance in ophthalmic surgery. In this report, we describe the preliminary findings of the Determination of feasibility of Intraoperative Spectral domain microscope Combined/integrated OCT Visualisation during En face Retinal and ophthalmic surgery (DISCOVER) study, a multisurgeon investigational device study examining the role of microscope integrated iOCT systems with surgeon heads-up display feedback (eg, Carl Zeiss Meditec RESCAN 700, Cole Eye Institute iOCT prototype). During surgical manoeuvres in anterior segment and posterior segment surgery, this technology provides rapid visualisation of the area of interest and provides the surgeon with information regarding instrument-tissue interactions. This system represents a major advance in iterative technology for iOCT and may provide the first widely available platform for surgeons to seamlessly assimilate this technology into the operating room theatre.
(+)-Catechin is more bioavailable than (−)-catechin: Relevance to the bioavailability of catechin from cocoa (2006)

Catechin is a flavonoid present in fruits, wine and cocoa products. Most foods contain the (+)-enantiomer of catechin but chocolate mainly contains ( - )-catechin, in addition to its major flavanol, ( - )-epicatechin. Previous studies have shown poor bioavailability of catechin when consumed in chocolate. We compared the absorption of ( - ) and (+)-catechin after in situ perfusion of 10, 30 or 50 micromol/l of each catechin enantiomer in the jejunum and ileum in the rat. We also assayed 23 samples of chocolate for (+) and ( - )-catechin. Samples were analyzed using HPLC with a Cyclobond I-2000 RSP chiral column. At all concentrations studied, the intestinal absorption of ( - )-catechin was lower than the intestinal absorption of (+)-catechin (p < 0.01). Plasma concentrations of ( - )-catechin were significantly reduced compared to (+)-catechin (p < 0.05). The mean concentration of ( - )-catechin in chocolate was 218 +/- 126 mg/kg compared to 25 +/- 15 mg/kg (+)-catechin. Our findings provide an explanation for the poor bioavailability of catechin when consumed in chocolate or other cocoa containing products.