gebhart/patrepeval huggingface dataset:
Analysis on Channel Estimation for the Equalization in ATSC DTV Receivers (2005)

This paper presents analysis results on finite-impulse response (FIR) channel estimation used for the equalization in Advanced Television Systems Committee digital television receivers. While channel estimation results have been effectively used for the equalization, the conditions of sufficient order and high signal-to-noise ratio (SNR) were assumed in most cases. To compensate for these unrealistic assumptions, we consider diverse probable conditions for channel estimation, such as reduced order and low SNRs, and then theoretically analyze each estimation case. The analysis shows that the adaptive FIR channel estimator provides an unbiased estimation and matches well its corresponding channel coefficients irrespective of the number of taps of the estimator and the non-causality of the unknown channel. Simulation results verify our analysis on the estimation of terrestrial DTV channels.
Random PWM inverter drive systems: theory and practice (2002)

A three-phase PWM inverter system for AC motor control using a random switching strategy (RPWM) to reduce the perceived acoustic noise from the drive is described. It allows the use of low-resolution timers with simple microcontrollers and power switching devices, by incorporating a vector-integral feedback strategy within the actual PWM waveform generator thereby ensuring that errors cannot accumulate. A theoretical analysis of. The RPWM waveforms is shown to be in close agreement with experimental observations so that power spectra can be tailored for specific applications to produce a quiet general purpose drive with essentially no price premium over a conventional one.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Biomechanical and Optical Characteristics of a Corneal Stromal Equivalent1 (2003)

Cell matrix interactions are important in understanding the healing characteristics of the cornea after refractive surgery or transplantation. The purpose of this study was to characterize in more detail the evolution of biomechanical and optical properties of a stromal equivalent (stromal fibroblasts cultured in a collagen matrix). Human corneal stromal fibroblasts were cultured in a collagen matrix. Compaction and modulus were determined for the stromal equivalent as a function of time in culture and matrix composition. The corneal stromal fibroblasts were stained for alpha-smooth muscle actin expression as an indicator of myofibroblast phenotype. The nominal modulus of the collagen matrix was 364 +/- 41 Pa initial and decreased initially with time in culture and then slowly increased to 177 +/- 75 Pa after 21 days. The addition of chondroitin sulfate decreased the contraction of the matrix and enhanced its transparency. Cell phenotype studies showed dynamic changes in the expression of alpha-smooth muscle actin with time in culture. These results indicate that the contractile behavior of corneal stromal cells can be influenced by both matrix composition and time in culture. Changes in contractile phenotype after completion of the contraction process also indicate that significant cellular changes persist beyond the initial matrix-remodeling phase.
Generation of Optical 32QAM using Two Tandem IQ Modulators with Simplified Electronics (2013)

We propose and demonstrate an optical 32QAM transmitter, consisting of two tandem IQ modulators driven by binary and 3-level electronics. Compared with the single-IQ modulator scheme requiring 6-level electronics, the complexity in electronics is reduced.
Supplemental Figure S3 from Plasma KIM-1 Is Associated with Recurrence Risk after Nephrectomy for Localized Renal Cell Carcinoma: A Trial of the ECOG-ACRIN Research Group (E2805) (2023)

&lt;p&gt;Association between paired baseline and C2D1 plasma KIM-1 values&lt;/p&gt;
ChemInform Abstract: SYNTHESIS AND PHOTOCHEMICAL DECOMPOSITION OF SOME SUBSTITUTED 1,2‐, 1,2,3‐, AND 1,2,4‐AZAFULVENES (1974)

Abstract Aus den Triazol‐4‐carbonsäureestern (I) erhält man mit Phenyllithium (I‐I) die Addukte (III) und (IV); aus (Ia) entsteht mit Phenyllithium und 2,2′‐Dilithiodiphenyl das Fluorenol (V).
Intracellular drug delivery inLeishmania-infected macrophages: Evaluation of saponin-loaded PLGA nanoparticles (2011)

Drug delivery systems present an opportunity to potentiate the therapeutic effect of antileishmanial drugs. Colloidal carriers are rapidly cleared by the phagocytic cells of the reticuloendothelial system (RES), rendering them ideal vehicles for passive targeting of antileishmanials. This paper describes the development of poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) for the antileishmanial saponin β-aescin. NPs were prepared using the combined emulsification solvent evaporation/salting-out technique. Confocal microscopy was used to visualise the internalisation and intracellular trafficking of fluorescein- and nile red-labelled PLGA NPs in J774A.1 macrophages infected with GFP-transfected Leishmania donovani. The in vitro activity of aescin and aescin-loaded NPs on L. infantum was determined in the axenic model as well as in the ex vivo model. The developed PLGA NPs were monodispersed with Z(ave)<300 nm, exhibited negative zeta potentials and had relatively high drug loadings ranging from 5.80 to 8.68% w/w PLGA. The fluorescent NPs were internalised by the macrophages and trafficked towards the lysosomes after 2 h in vitro incubation. Co-localisation of the NPs and the parasite was not shown. A two-fold increase in activity was observed in the ex vivo macrophage model by encapsulating β-aescin in PLGA NPs (IC(50), 0.48-0.76 µg/mL vs. 1.55 ± 0.32 µg/mL for the free drug).
Doping dependence of upper critical field and hall resistivity in LaFeAsO1-xFx (x=0, 0.025, 0.5, 0.07, 0.11 and 0.14) (2024)

The electrical resistivity ({rho}{sub xx}) and Hall resistivity ({rho}{sub xy}) have been measured over wide composition range using 60 T pulsed magnets. While the superconducting phase diagram (T{sub c}, x) displays the classic dome-shaped structure, we find that the upper critical field (H{sub c2}) increases monotonically with decreasing fluorine concentration (x), with the largest H{sub c2} {&gt;=} 75 T for x = 0.05. {rho}{sub xx} and {rho}{sub xy} data provide evidence for the multiband electronic structure for all x {&lt;=} 0.14 in LaFeAsO{sub 1-x}F{sub x}, and demonstrate the quantum phase transition near x {approx} 0.05. Both the multiband structure and quantum phase transition play crucial roles in the large H{sub c2}.
<title>Nondimensional beam parameters and the wave structure function</title> (1992)

Two pairs of nondimensional beam parameters are identified, either of which combined with wavelength and path length completely characterizes the diffractive propagation environment of a Gaussian beam. One pair is associated with the beam radius and radius of curvature at the transmitter while the other pair is associated with these same quantities at the receiver. The fundamental nature of the receiver parameters is revealed in the simple analytic forms for the wave structure function derived under the assumption of a modified Kolmogorov spectral model for refractive index fluctuations.
Data from A Novel, Fully Human Anti–fucosyl-GM1 Antibody Demonstrates Potent <i>In Vitro</i> and <i>In Vivo</i> Antitumor Activity in Preclinical Models of Small Cell Lung Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; The ganglioside fucosyl-GM1 (FucGM1) is a tumor-associated antigen expressed in a large percentage of human small cell lung cancer (SCLC) tumors, but absent in most normal adult tissues, making it a promising target in immuno-oncology. This study was undertaken to evaluate the preclinical efficacy of BMS-986012, a novel, nonfucosylated, fully human IgG1 antibody that binds specifically to FucGM1.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; The antitumor activity of BMS-986012 was evaluated in &lt;i&gt;in vitro&lt;/i&gt; assays using SCLC cells and in mouse xenograft and syngeneic tumor models, with and without chemotherapeutic agents and checkpoint inhibitors.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; BMS-986012 showed a high binding affinity for FcγRIIIa (CD16), which resulted in enhanced antibody-dependent cellular cytotoxicity (ADCC) against FucGM1-expressing tumor cell lines. BMS-986012–mediated tumor cell killing was also observed in complement-dependent cytotoxicity (CDC) and antibody-dependent cellular phagocytosis (ADCP) assays. In several mouse SCLC models, BMS-986012 demonstrated efficacy and was well tolerated. In the DMS79 xenograft model, tumor regression was achieved with BMS-986012 doses of 0.3 mg/kg and greater; antitumor activity was enhanced when BMS-986012 was combined with standard-of-care cisplatin or etoposide. In a syngeneic model, tumors derived from a genetically engineered model of SCLC were treated with BMS-986012 or anti-FucGM1 with a mouse IgG2a Fc and their responses evaluated; when BMS-986012 was combined with anti–PD-1 or anti-CD137 antibody, therapeutic responses significantly improved.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Single-agent BMS-986012 demonstrated robust antitumor activity, with the addition of chemotherapeutic or immunomodulatory agents further inhibiting SCLC growth in the same models. These preclinical data supported evaluation of BMS-986012 in a phase I clinical trial of patients with relapsed, refractory SCLC. &lt;i&gt;Clin Cancer Res; 24(20); 5178–89. ©2018 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Lie Group Cohomology and (Multi)Symplectic Integrators : New Geometric Tools for Lie Group Machine Learning based on Souriau Geometric Statistical Mechanics (2020)

In this paper we describe and exploit a geometric framework for Gibbs probability densities and the associated concepts in statistical mechanics, which unifies several earlier works on the subject, including Souriau's symplectic model of statistical mechanics, its polysymplectic extension, Koszul model, and approaches developed in quantum information geometry. We emphasize the role of equivariance with respect to Lie group actions and the role of several concepts from geometric mechanics, such as momentum maps, Casimir functions, coadjoint orbits, and Lie-Poisson brackets with cocycles, as unifying structures appearing in various applications of this framework to information geometry and machine learning. For instance, we discuss the expression of the Fisher metric in presence of equivariance and we exploit the property of the entropy of the Souriau model as a Casimir function to apply a geometric model for energy preserving entropy production. We illustrate this framework with several examples including multivariate Gaussian probability densities, and the Bogoliubov-Kubo-Mori metric as a quantum version of the Fisher metric for quantum information on coadjoint orbits. We exploit this geometric setting and Lie group equivariance to present symplectic and multisymplectic variational Lie group integration schemes for some of the equations associated to Souriau symplectic and polysymplectic models, such as the Lie-Poisson equation with cocycle.
Dopamine enhances glutamate-activated currents in spinal motoneurons (1995)

In cultured embryonic chick motoneurons, glutamate-activated currents rise quickly and then decay rapidly to relatively small steady-state current levels. Dopaminergic modulation of these receptors was studied using patch-clamp recording techniques. At concentrations > or = 10 nM, dopamine enhanced glutamate-activated currents by about 200%. This enhancement was diminished by the nonspecific dopamine receptor antagonist S(+)-apomorphine and the more specific D1 receptor antagonist SCH23390, and it was mimicked by the D1 partial agonist SKF38393. Glutamate receptor desensitization rate was not altered in the presence of dopamine. Enhancement was specific to the kainate component. Current-variance analysis indicated that in the presence of dopamine the conductances of glutamate-activated channels were not altered but that the relative fraction of kainate-type channels activated by glutamate increased. Intracellular cAMP levels increased by 33% following exposure to 100 microM dopamine. The effects of elevated cAMP or protein kinase A (PKA) were tested by including 100 microM cAMP or PKA, respectively, in the recording pipette solution. This increased the kainate-activated currents specifically. Dopaminergic enhancement was not observed when a PKA inhibitor was in the pipette. mRNA encoding D1 was detected in the spinal cord by a reverse transcription, polymerase chain-reaction amplification procedure. Thus, dopamine is acting most probably on an avian homolog of the D1 receptor family. We conclude that dopamine causes cAMP to increase, which results in increased activation of kainate-gated channels during glutamate-mediated transmission.
Channel and flow adaptive multiuser DMT (2003)

This paper considers the design of biorthogonal DMT multicarrier transceiver systems supporting multiple services. The supported user services may have differing quality of service (QoS) requirements, quantified by bit rate and symbol error rate specifications. Our goal is to minimize the transmitted power given the QoS specifications for the different users, subject to the knowledge of colored interference at the receiver input of the DMT system. In particular, we find an optimum bit loading scheme that distributes the bit rate transmitted across the various subchannels belonging to the different users, and subject to this bit allocation, determine an optimum transceiver. This work differs from our prior work where orthonormal transceivers were considered.
ISOMERIZATION OF LONGIFOLENE TO ISOLONGIFOLENE CATALYZED BY MONTMORILLONITE CLAY (1999)

(1999). ISOMERIZATION OF LONGIFOLENE TO ISOLONGIFOLENE CATALYZED BY MONTMORILLONITE CLAY. Organic Preparations and Procedures International: Vol. 31, No. 2, pp. 227-230.
A New Class of Low Cost, High Performance Radiation Detectors (2006)

A new class of radiation detectors has been conceived and demonstrated using plasma panel TV-set technology for direct conversion of ionizing radiation to free-electrons and a gaseous media for electron amplification with a gain of approximately 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sup> . For the basic configuration, a native pixel resolution of 10 mum appears feasible, with a pixel response time of 1 mus or faster, and a manufacturing cost of less than $1 per square inch for detector and electronics. New structures under consideration suggest the possibility that the plasma panel detector could be a transformational technology with low cost, large area, high spatial and temporal resolution, and potentially high efficiency, high energy spectral resolution and high neutron/gamma-ray discrimination
Mechanical Tests of Adhesive Bond Performance (2012)

No AccessAdhesion and Adhesives TechnologyJun 2012Mechanical Tests of Adhesive Bond PerformanceAlphonsus V. PociusAlphonsus V. Pociushttps://doi.org/10.3139/9783446431775.003SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2012Pages: 47-83Print ISBN: 978-3-446-42748-8eISBN: 978-3-446-43177-5 Copyright & Permissions© 2012 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Robust measurement of flexoelectro-optic switching with different surface alignments (2019)

The alignment of chiral nematic liquid crystals in the so-called uniform lying helix geometry allows for the observation and exploitation of the flexoelectro-optic effect. However, high-quality uniform lying helix alignment is difficult to achieve reliably, and this can potentially impact the accuracy of the measurements made on the flexoelectro-optic switching behaviour. Here, we show that, using an appropriate method, it is possible to make measurements of the flexo-electric coefficients that are not substantially influenced by the alignment quality.
Improvement of stem cell performance by supplementation with metabolic enhancers (2011)

Practical culture methods for expansion of human stem cells are needed for research and industrial applications. In general, ingredients of known and unknown composition have been used in stem cell cultures based on past studies and practices. To harness the substantial potential of stem cells in treating human diseases, products with improved characteristics are needed to support the manufacturing of stem cells for cell therapy use. Safety, definition, cost and consistency are key considerations for all new stem cell products. Based on data mining and cell-based screens, we have designed the RS Novo™ defined small molecule metabolic enhancers for expansion of human embryonic (ESC), mesenchymal (MSC) and hematopoietic stem cells with limited differentiation. Cell growth, viability, phenotype and stem cell potential were endpoints of interest in our studies. Our aim was to minimize media components that would “trigger” stem cells into differentiation, apoptosis, and necrosis. We also aimed to minimize undefined components like serum that could introduce inconsistencies. Here, we cover some RS Novo™ results with human MSC and ESC and introduce the GEM Novo™ serum free medium for a more complete culture system for stem cell expansion. Cells grown in this culture system maintained their stem cell phenotype and potencies. For example, at different passages, human ESC H7 clone maintained the Oct-4 marker of undifferentiated cells more consistently in this system versus a culture system optimized by others (Table ​(Table1),1), and human MSC expanded in GEM Novo containing RS Novo and then transferred to differentiation media could differentiate into adipocytes (Figure ​(Figure1).1). Altogether, this new culture system provides a consistent, high performance condition for human stem cell expansion.



Table 1

Consistent marker expression at different passages of human ESC culture in GEM Novo medium containing RS Novo, determined by mean fluorescence intensity (MFI) of Oct-4 staining by flow cytometry.





Figure 1

Human MSC expanded in GEM Novo containing RS Novo can later differentiate into adipocytes as demonstrated here by Oil Red O staining.
Dichroic Properties and the Molecular Tilt Angle of a Large-Tilt Angle Antiferroelectric Liquid Crystal Studied Using Polarized Infrared Spectroscopy (2006)

The voltage dependencies of the dichroic properties for a homogeneously aligned sample of a partly fluorinated chiral smectic liquid crystal (S)-4-(1-methylheptyloxy carbonyl)phenyl 4′-[6-(3,4,4,4-tetrafluoro-3-trifluoromethylbutylcarbonyloxy) hexyloxy] biphenyl-4-carboxylate at various temperatures have been studied using polarized Fourier transform infrared spectroscopy. The temperature dependence of the molecular apparent tilt angle has also been determined. For the antiferroelectric SmC A * phase, the molecular apparent tilt angle is found to be close to 45° for a temperature range of 65–80°C. In the SmA* phase, an application of a sufficiently high electric fields causes a substantial increase in the orientational order parameter. This results probably from a change in the azimuthal distribution of the molecular directors around the tilt cone. The material is found to exhibit an extraordinary large surface electroclinic effect and its helix is considerably distorted by the surfaces.
NGSQC: cross-platform quality analysis pipeline for deep sequencing data (2010)

Next generation sequencing platforms have their own share of quality issues and there can be significant lab-to-lab, batch-to-batch and even within chip/slide variations. NGSQC can help to ensure that biological conclusions, in particular those based on relatively rare sequence alterations, are not caused by low quality sequencing.
Breast Deformation in Near Infrared Optical Tomography (2004)

In NIR tomography of the breast, good contact is needed by the fibers, resulting in breast deformation. We present a deformation model to account for the change of shape and discuss implications in image reconstruction.
The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer (2023)

Comprehensive characterization of the five subtypes of metastatic castration-resistant prostate cancer identified transcription factors that drive each subtype and showed that the double-negative subtype has the worst prognosis.
Leucine-rich Amelogenin Peptides Regulate Mineralization in vitro (2011)

Amelogenin's capacity to regulate enamel formation is related to its conserved N- and C-terminal domains, its ability to self-assemble, and its ability to stabilize amorphous calcium phosphate (ACP) - a capacity enhanced by amelogenin phosphorylation. This in vitro study provides further insight into amelogenin function, using variations of the Leucine-Rich Amelogenin Peptide (LRAP), an alternative splice product comprised solely of amelogenin's N- and C-terminal domains. Peptide self-assembly was studied by dynamic light-scattering and transmission electron microscopy (TEM). TEM, selected area electron diffraction, and Fourier transform-infrared spectroscopy were also used to determine the effect of phosphorylated and non-phosphorylated LRAP on calcium phosphate formation. Results show that phosphorylated and non-phosphorylated LRAP can self-assemble into chain-like structures in a fashion dependent on the C-terminal domain. Notably, this capacity was enhanced by added calcium and to a much greater degree for phosphorylated LRAP. Furthermore, phosphorylated LRAP was found to stabilize ACP and prevent its transformation to hydroxyapatite (HA), while aligned HA crystals formed in the presence of non-phosphorylated LRAP. The N- and C-terminal amelogenin domains in non-phosphorylated LRAP are, therefore, sufficient to guide ACP transformation into ordered bundles of apatite crystals, making LRAP an excellent candidate for biomimetic approaches for enamel regeneration.
Dietary Supplementation with Fructooligosaccharides Attenuates Airway Inflammation Related to House Dust Mite Allergen in Mice (2010)

Fructooligosaccharides (FOS) are prebiotic supplements that can enhance immunological responses in the host to activate mucosal immunity, probably through regulation of gastrointestinal microflora. An area that has not been investigated, however, is the therapeutic potential of prebiotics on allergic airway diseases. The purpose of this study is to evaluate the effects of dietary supplementation with FOS on a murine model of allergic airway inflammation induced by the house dust mite allergen Dermatophagoides farinae (Der f). Male C3H/HeN mice were intratracheally administered with Der f and were fed a diet containing 0% or 2.5% FOS ad libitum. Supplementation with FOS alleviated mite allergen-related airway inflammation characterized by eosinophilic inflammation and goblet cell hyperplasia, which was evidenced by cytological and histological examinations. In addition, the FOS-supplemented diet reduced the serum allergen-specific IgG1 level as compared with a control diet in the presence of the mite allergen. Moreover, FOS tended to suppress the expression of IL-5 and eotaxin in the lungs, which is enhanced by mite allergen. These results suggest that dietary supplementation with FOS can prevent/improve allergic airway inflammation induced by the mite allergen. This effect can be at least partially associated with the inhibition of allergen-specific Ig production and probably with that of IL-5 and eotaxin expression.