gebhart/patrepeval huggingface dataset:
Effect of Cyclosporine on Serum LH in the Castrate Rat (1987)

No AccessJournal of Urology1 Jun 1987Effect of Cyclosporine on Serum LH in the Castrate Rat Suresh C. Sikka, Martin A. Koyle, and Jacob Rajfer Suresh C. SikkaSuresh C. Sikka More articles by this author , Martin A. KoyleMartin A. Koyle More articles by this author , and Jacob RajferJacob Rajfer More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)76086-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Effect of Cyclosporine on Serum LH in the Castrate Rat." The Journal of Urology, 137(6), p. 338A © 1987 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 137Issue 6June 1987Page: 338A Advertisement Copyright & Permissions© 1987 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Suresh C. Sikka More articles by this author Martin A. Koyle More articles by this author Jacob Rajfer More articles by this author Expand All Advertisement PDF DownloadLoading ...
The GOES-R Geostationary Lightning Mapper (GLM) and the Global Observing System for Total Lightning (2014)

for the existing GOES system currently operating over the Western Hemisphere. New and improved instrument technology will support expanded detection of environmental phenomena, resulting in more timely and accurate forecasts and warnings. Advancements over current GOES include a new capability for total lightning detection (cloud and cloud-to-ground flashes) from the Geostationary Lightning Mapper (GLM), and improved temporal, spatial, and spectral resolution for the next generation Advanced Baseline Imager (ABI). The GLM will map total lightning continuously day and night with near-uniform spatial resolution of 8 km with a product latency of less than 20 sec over the Americas and adjacent oceanic regions. This will aid in forecasting severe storms and tornado activity, and convective weather impacts on aviation safety and efficiency among a number of potential applications. The GLM will help address the National Weather Service requirement for total lightning observations globally to support warning decision-making and forecast services. Science and application development along with pre-operational product demonstrations and evaluations at NWS national centers, forecast offices, and NOAA testbeds will prepare the forecasters to use GLM as soon as possible after the planned launch and check-out of GOES-R in 2016. New applications will use GLM alone, in combination with the ABI, or integrated (fused) with other available tools (weather radar and ground strike networks, nowcasting systems, mesoscale analysis, and numerical weather prediction models) in the hands of the forecaster responsible for issuing more timely and accurate forecasts and warnings.
A Century of Progress on Wilson Disease and the Enduring Challenges of Genetics, Diagnosis, and Treatment (2023)

Wilson disease (WD) is a rare, inherited metabolic disorder manifested with varying clinical presentations including hepatic, neurological, psychiatric, and ophthalmological features, often in combination. Causative mutations in the <i>ATP7B</i> gene result in copper accumulation in hepatocytes and/or neurons, but clinical diagnosis remains challenging. Diagnosis is complicated by mild, non-specific presentations, mutations exerting no clear effect on protein function, and inconclusive laboratory tests, particularly regarding serum ceruloplasmin levels. As early diagnosis and effective treatment are crucial to prevent progressive damage, we report here on the establishment of a global collaboration of researchers, clinicians, and patient advocacy groups to identify and address the outstanding challenges posed by WD.
Nondestructive imaging with mercuric iodide thick film x-ray detectors (2001)

Polycrystalline mercuric iodide (HgI2) photoconductor material was directly deposited on flat panel amorphous silicon (a-Si) thin film transistor (TFT) pixel arrays in order to test their application as direct x-ray conversion detectors. The 4' x 4' and 2' x 2' detector plates were fabricated either by Physical Vapor Deposition (PVD) or the Screen-Print (SP) method. Although developed for medical radiological imaging, they can also be used for nondestructive test imaging. The present HgI2 arrays have 100 &mu;m x 100 &mu;m pixels on the 2' x 2' detector and 139&mu;m x 139&mu;m on the 4' x 4' imager. The initial results are very promising and show high x-ray sensitivity and low leakage current. The advantage of these detectors is that they can be directly deposited on the pixellated arrays containing the TFTs and other electronic read out circuits and can be fabricated in large sizes. These polycrystalline PVD-HgI<SUB>2</SUB> thick film detectors have now been fabricated up to 1,800&mu;m thick, which makes them also useful for higher-energy X-ray applications. Imaging results obtained by both PVD- and SP-HgI<SUB>2</SUB> will be shown. The effect of the crystallite size on the imaging properties will be demonstrated and the difference in sensitivity applying positive or negative bias on the top electrode will be discussed. Comparison of x-ray sensitivity to other photoconductor materials such a-Se and PbI<SUB>2</SUB> will also be presented.
A Dual Stage Planar Cable Robot: Dynamic Modeling and Design of a Robust Controller With Positive Inputs (2004)

Cable robots have been extensively used for loading and unloading of cargo in shipping industries. A novel six-degree of freedom two-stage cable robot has been proposed by NIST for skin-to-skin transfer of cargo. In this paper, we look at a planar version of this two-stage cable robot. The disturbance motion from the sea is considered while modeling the dynamics of robot. The problem of robust control of the end-effector in the presence of unknown disturbances, along with maintaining positive tensions in the cables, is tackled by using the idea of redundancy. Simulation results show the effectiveness of the control strategy.
Direct Interaction of Kindlin-3 With Integrin αIIbβ3 in Platelets Is Required for Supporting Arterial Thrombosis in Mice (2014)

These observations demonstrate that the direct binding of kindlin-3 to integrin αIIbβ3 is involved in supporting integrin αIIbβ3 activation and integrin αIIbβ3-dependent responses of platelets and consequently contributes significantly to arterial thrombus formation.
Effect of Vaccination Route and the Dose of Adjuplex and OVA on the Magnitude of CD8 T-cell Responses. (2016)

&lt;p&gt;(&lt;b&gt;A&lt;/b&gt;) Intramuscular and subcutaneous vaccination with increasing doses of Adjuplex generate comparable primary CTL responses. WT C57BL/6 mice were vaccinated by intramuscular or subcutaneous injection of 10 μg ovalbumin in PBS alone or mixed with 5, 10 or 20% Adjuplex. At day 7 after vaccination, percentages of SIINFEKL-specific IFN-γ&lt;sup&gt;+&lt;/sup&gt; CD8 T cells in spleen were determined by intracellular staining. (&lt;b&gt;B&lt;/b&gt;) Primary OVA-specific CTL responses in the spleen are proportionate to SQ vaccination with increasing doses of Adjuplex and OVA. C57BL/6 mice were vaccinated by subcutaneous injection of 1, 3, or 10 μg ovalbumin in PBS alone or supplemented with 1,3, 5 or 10% Adjuplex. The bar graph represents the frequency of SIINFEKL-specific IFN-γ&lt;sup&gt;+&lt;/sup&gt; CD8 T cells among all CD8&lt;sup&gt;+&lt;/sup&gt; splenocytes after vaccination at each dose&lt;b&gt;.&lt;/b&gt; Data are from analysis of 3–4 mice/group and are representative of two independent experiments.&lt;/p&gt;
Aggregation and mobility of membrane proteins interplay with local lipid order in the plasma membrane of T cells (2021)

To disentangle the elusive lipid-protein interactions in T-cell activation, we investigate how externally imposed variations in mobility of key membrane proteins (T-cell receptor [TCR], kinase Lck, and phosphatase CD45) affect the local lipid order and protein colocalisation. Using spectral imaging with polarity-sensitive membrane probes in model membranes and live Jurkat T cells, we find that partial immobilisation of proteins (including TCR) by aggregation or ligand binding changes their preference towards a more ordered lipid environment, which can recruit Lck. Our data suggest that the cellular membrane is poised to modulate the frequency of protein encounters upon alterations of their mobility, for example in ligand binding, which offers new mechanistic insight into the involvement of lipid-mediated interactions in membrane-hosted signalling events.
Functional ultrasound imaging of the human brain activity: An intraoperative pilot study for cortical functional mapping (2016)

A wide spectrum of methods is used to image brain activation in vivo, such as functional MRI (fMRI) or positron emission tomography. Both techniques have excellent depth penetration but do not provide good spatial nor temporal resolution. By contrast, ultrasound imaging achieves good spatiotemporal resolution in depth, but until now its poor sensitivity has limited its use to the imaging of major vessels. Functional ultrasound (fUS) derived from the key concept of ultrafast imaging (up to 20 000 frames/s) overcomes this limitation. fUS enables high spatiotemporal resolution imaging of microvasculature dynamics in response to brain activation and was previously validated in rodents. We aim to demonstrate that fUS could find activation maps accurately during brain surgery in humans without requiring electrocortical stimulation mapping (ESM). A clinical study including 10 patients with brain lesion is undertaken, with both fMRI and ESM as gold standard. Patients underwent fMRI before surgery, data were intraoperatively used for ultrasound probe positioning on a targeted functional area using a neuronavigation system (Brainlab AG, Feldkirchen, Germany) and probe location was also confirmed by ESM. A sterilized linear probe driven by an ultrafast ultrasound scanner (Aixplorer, Supersonic Imagine, France) was placed directly on the brain after skull opening. Patients, awake during this part of their surgery, were asked to perform a specific task (motor, sensory or language). fUS imaging with a 6000 Hz frame rate determines regions of brain activity based on the cerebral blood volume (CBV) increase due to neurovascular coupling. This first pilot study demonstrates the ability of fUS imaging to map with a high signal-to-noise ratio (SNR) the stimulus-based neuronal activation in depth in real time during brain surgery. Such technique could be extremely useful for neurosurgeons to improve their surgery and therefore patient quality of life.
All‐Inkjet‐Printed, All‐Air‐Processed Solar Cells (2014)

The prospective of using direct‐write printing techniques for the manufacture of organic photovoltaics (OPVs) has made these techniques highly attractive. OPVs have the potential to revolutionize small‐scale portable electronic applications by directly providing electric power to the systems. However, no route is available for monolithically integrating the energy‐harvesting units into a system in which other components, such as transistors, sensors, or displays, are already fabricated. Here, the fabrication and the measurement of inkjet‐printed, air‐processed organic solar cells is reported for the first time. Highly controlled conducting and semiconducting films using engineered inks for inkjet printing enable good efficiencies for printed OPVs between ≈2 and 5% power conversion efficiency. The results show that inkjet printing is an attractive digital printing technology for cost‐effective, environmentally friendly integration of photovoltaic cells onto plastic substrates.
Sucrose Transport in Plants Using Monofluorinated Sucroses and Glucosides (1988)

The sucrose carrier in the outer membrane of cells of developing soybean cotyledons recognizes and transports sucrose derivitives which are singly fluorinated at C-1′, C-4′, and C-6′. Some a -glucosides are also recognized and transported and may be used as sucrose analogs in studying carrier-substrate interaction. Phenyl a -D-thioglucopyranosides fluorinated singly at positions C-3, C-4, and C-6 along with the deoxy-glucosides at these positions indicate that recognition by the plant carrier requires interaction at these three hydroxyls along with hydrophobic interaction with the β -face of the glucose moiety and the a -face of the fructose moiety in sucrose. 1′-Deoxy-1′-fluorosucrose is also recognized and transported by the carrier proteins in the vascular tissues of leaves and is thus moved in long distance transport in a manner identical to sucrose. At limiting substrate concentrations, 1′-deoxy-1′-fluorosucrose is metabolized by sucrose synthase at a rate 3.6 times slower than sucrose. Hydrolysis by invertase however occurs at a rate 4200 times slower than sucrose. In vivo rates of metabolism for the 1′-fluoro derivitive and for sucrose showed that sucrose is metabolized by both enzymes acting in parallel, and that the relative contribution of the individual enzymes varies with tissue development.
Lung development: orchestrating the generation and regeneration of a complex organ (2014)

The respiratory system, which consists of the lungs, trachea and associated vasculature, is essential for terrestrial life. In recent years, extensive progress has been made in defining the temporal progression of lung development, and this has led to exciting discoveries, including the derivation of lung epithelium from pluripotent stem cells and the discovery of developmental pathways that are targets for new therapeutics. These discoveries have also provided new insights into the regenerative capacity of the respiratory system. This Review highlights recent advances in our understanding of lung development and regeneration, which will hopefully lead to better insights into both congenital and acquired lung diseases.
The Synthesis and X-Ray Structural Studies of Bis(1,3,2-Dithiaphospholane) (1999)

Abstract The title compound 1 [31P NMR (CD3CN): σ=36.7ppm] has been identified among the products of controlled hydrolysis of 2-dimethoxyphosphory1-1,3,2-dithiaphospholane (2) [1].
The use of a virtual reality haptic device in surgical training (1998)

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Silica-Polymer Composite Particles for Toners: Synthesis, Characterization and Performance (2013)

Evolution of toner technology together with a demand for faster printing puts new requirements on external additives used in toner formulations. Spacer particles, which are added to protect the toner surface from mechanical stress resulting from collisions with the particles of carrier or the doctor blade, have become a progressively more important part of the additives packages.Polymeric particles, colloidal silica, and low surface area fumed silica are usually used as spacers. However, each of these materials has significant drawbacks. For instance, triboelectric charging properties of polymeric particles are not always optimal, large colloidal silica often drops off from toner surface, and low surface area fumed silica typically has broader than desired aggregate size distribution.At the NIP28 conference we introduced the organic/inorganic composite spacer additives which combine benefits of polymeric and colloidal silica spacer additives [1]. We demonstrated that the new particles have lower drop off from the toner surface than colloidal silica additives.In this paper we demonstrate how the new material particle size and shape could be controlled and present results of a print test where a model toner was formulated with the silica-polymer composite spacer additives.
Operating System Support for Inter-Domain Type Checking. (1996)

Most existing file based operating systems tend to provide very little in the way of type related information about applications to the user. Instead, the user is required to construct applications that perform their own type checking, relying on information about existing programs and data to be obtained via other means, such as manual pages, or by visual inspection of source code. This lack of public type related information has, by and large, prevented the benefits of browsing technology as found in some persistent language systems to be delivered to the operating system level. A technique is examined in which detailed type information about operating system entities may be recorded, thus enabling more informative user interfaces, tools and applications to be constructed.
FELICX: A robust nucleic acid detection method using flap endonuclease and CRISPR-Cas12 (2022)

Nucleic acid detection is crucial for monitoring diseases for which rapid, sensitive, and easy-to-deploy diagnostic tools are needed. CRISPR-based technologies can potentially fulfill this need for nucleic acid detection. However, their widespread use has been restricted by the requirement of a protospacer adjacent motif in the target and extensive guide RNA optimization. In this study, we developed FELICX, a technique that can overcome these limitations and provide a useful alternative to existing technologies. FELICX comprises flap endonuclease, Taq ligase and CRISPR-Cas for diagnostics (X) and can be used for detecting nucleic acids and single-nucleotide polymorphisms. This method can be deployed as a point-of-care test, as only two temperatures are needed without thermocycling for its functionality, with the result generated on lateral flow strips. As a proof-of-concept, we showed that up to 0.6 copies/μL of DNA and RNA could be detected by FELICX in 60 min and 90 min, respectively, using simulated samples. Additionally, FELICX could be used to probe any base pair, unlike other CRISPR-based technologies. Finally, we demonstrated the versatility of FELICX by employing it for virus detection in infected human cells, the identification of antibiotic-resistant bacteria, and cancer diagnostics using simulated samples. Based on its unique advantages, we envision the use of FELICX as a next-generation CRISPR-based technology in nucleic acid diagnostics.
Supplementary Figure 1 from Transcription Factor Stat5 Knockdown Enhances Androgen Receptor Degradation and Delays Castration-Resistant Prostate Cancer Progression <i>In vivo</i> (2023)

Supplementary Figure 1 from Transcription Factor Stat5 Knockdown Enhances Androgen Receptor Degradation and Delays Castration-Resistant Prostate Cancer Progression &lt;i&gt;In vivo&lt;/i&gt;
P2A-5 Effect of Contrast Microbubble Concentration on Quality of Echo Particle Image Velocimetry (Echo PIV) Data: Initial In Vitro Studies (2006)

We have recently developed a novel contrast-based ultrasonic particle image velocimetry (Echo PIV) technique to measure multi-component velocity vectors in opaque flows. In the technique, ultrasound contrast microbubbles are used as flow tracers, and digitally acquired backscattered RF-data are used with custom velocimetry analysis to obtain velocity vectors. The technique has been shown as useful in obtaining 2D flow velocity from various flow patterns, including blood flow. Well control of timely sensitive microbubble concentration in Echo PIV is very important to produce robust data quality. In this paper, effect of microbubble concentration on Echo PIV data quality was examined and a quantitative tool based on feature of Echo PIV image cross-correlation was developed to evaluate real time robustness of Echo PIV data quality induced by bubble concentration and image quality
A 16Gb/s 65nm CMOS transceiver for a memory interface (2008)

A transceiver for a memory controller operating at 16 Gb/s per link is implemented in 65 nm CMOS process. Timing calibration, equalization and diagnostic circuits for both memory read and write are on the controller to optimize the overall system performance and cost. A 5-tap TX FIR and a continuous time RX equalizer with active inductor loads are employed. The transceiver also includes a diagnostic circuit which can add a programmable DC differential voltage offset and produce actual eye diagrams for both write and read links. It is demonstrated that each link can operate at 16 Gb/s with a timing margin of 0.19 UI at a BER of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> .
Backward compatible UHDTV transmission based on ADT system for the ATSC terrestrial DTV broadcasting (2013)

This paper proposes a backward compatible UHDTV transmission based on augmented data transmission (ADT) system for the ATSC terrestrial DTV broadcasting. The proposed system provides MPEG-2 DTV signal with a rate of 19.3 Mbps and HEVC-base ADT signal with a rate of about 7 Mbps. If we combine MPEG-2 DTV signal and HEVC-base ADT signal properly, we can provide 4K UHD video service as well as backward compatible HD video service simultaneously.
The Signatures of Autozygosity among Patients with Colorectal Cancer (2008)

Previous studies have shown that among populations with a high rate of consanguinity, there is a significant increase in the prevalence of cancer. Single nucleotide polymorphism (SNP) array data (Affymetrix, 50K XbaI) analysis revealed long regions of homozygosity in genomic DNAs taken from tumor and matched normal tissues of colorectal cancer (CRC) patients. The presence of these regions in the genome may indicate levels of consanguinity in the individual's family lineage. We refer to these autozygous regions as identity-by-descent (IBD) segments. In this study, we compared IBD segments in 74 mostly Caucasian CRC patients (mean age of 66 years) to two control data sets: (a) 146 Caucasian individuals (mean age of 80 years) who participated in an age-related macular degeneration (AMD) study and (b) 118 cancer-free Caucasian individuals from the Framingham Heart Study (mean age of 67 years). Our results show that the percentage of CRC patients with IBD segments (>or=4 Mb length and 50 SNPs probed) in the genome is at least twice as high as the AMD or Framingham control groups. Also, the average length of these IBD regions in the CRC patients is more than twice the length of the two control data sets. Compared with control groups, IBD segments are found to be more common among individuals of Jewish background. We believe that these IBD segments within CRC patients are likely to harbor important CRC-related genes with low-penetrance SNPs and/or mutations, and, indeed, two recently identified CRC predisposition SNPs in the 8q24 region were confirmed to be homozygous in one particular patient carrying an IBD segment covering the region.