gebhart/patrepeval huggingface dataset:
Information sharing for distributed planning (2010)

Large-scale collaborative planning is critical in many domains such as sensor networks and disaster rescue. In large, heterogeneous multiagent teams, agents must work together to create plans that maximize the effectiveness of the team as a whole; coordinating actions to increase efficiency while also avoiding potentially dangerous interactions between teammates. Recognizing the utility of information to agents in teams and delivering it efficiently across a team has also been the focus of much research, with proposed approaches ranging from classic flooding, gossiping, to channel filtering. We combine these two fields of research to study the problem of information sharing mechanisms to distribute planning in both certain and uncertain environments.
First spaceborne phase altimetry over sea ice using TechDemoSat‐1 GNSS‐R signals (2017)

Abstract A track of sea ice reflected Global Navigation Satellite System (GNSS) signal collected by the TechDemoSat‐1 mission is processed to perform phase altimetry over sea ice. High‐precision carrier phase measurements are extracted from coherent GNSS reflections at a high angle of elevation (&gt;57°). The altimetric results show good consistency with a mean sea surface (MSS) model, and the root‐mean‐square difference is 4.7 cm with an along‐track sampling distance of ∼140 m and a spatial resolution of ∼400 m. The difference observed between the altimetric results and the MSS shows good correlation with the colocated sea ice thickness data from Soil Moisture and Ocean Salinity. This is consistent with the reflecting surface aligned with the bottom of the ice‐water interface, due to the penetration of the GNSS signal into the sea ice. Therefore, these high‐precision altimetric results have potential to be used for determination of sea ice thickness.
Multispectral singlet oxygen and photosensitizer luminescence dosimeter for continuous photodynamic therapy dose assessment during treatment (2020)

These results suggest that O21 measurement may be a more direct dosimeter of PDT damage, and it has potential value as a definitive diagnostic for PDT treatment, especially with spectral separation of the background luminescence and online estimation of the PS concentration.
SessionJuggler (2012)

We use modern features of web browsers to develop a secure login system from an untrusted terminal. The system, called Session Juggler, requires no server-side changes and no special software on the terminal beyond a modern web browser. This important property makes adoption much easier than with previous proposals. With Session Juggler users never enter their long term credential on the untrusted terminal. Instead, users log in to a web site using a smartphone app and then transfer the entire session, including cookies and all other session state, to the untrusted terminal. We show that Session Juggler works on all the Alexa top 100 sites except eight. Of those eight, five failures were due to the site enforcing IP session binding. We also show that Session Juggler works flawlessly with Facebook connect. Beyond login, Session Juggler also provides a secure logout mechanism where the trusted phone is used to kill the session. To validate the session juggling concept we conducted a number of web site surveys that are of independent interest. First, we survey how web sites bind a session token to a specific device and show that most use fairly basic techniques that are easily defeated. Second, we survey how web sites handle logout and show that many popular sites surprisingly do not properly handle logout requests.
Preparation and properties of graphene oxide/polyimide composite films with low dielectric constant and ultrahigh strength via in situ polymerization (2011)

This study proposes an effective approach using in situpolymerization, to fabricate large-area graphene oxide (GO)/polyimide (PI) composite films with outstanding mechanical properties. The GO/PI composite films provide ultrahigh tensile strength (up to 844 MPa) and Young's modulus (20.5 GPa). The NH2-functionalized GO (ODA-GO) is a versatile starting platform for polymer grafting, promoting excellent dispersion of GO within the polymer matrix, and forming strong links with the polymer to facilitate load transfer. The Young's modulus of the integrated GO–PI composite films with 3.0 wt% ODA-GO loading is 15 times greater, and the tensile strength is 9 times greater than comparable properties of pure PI film. The dielectric constant decreases with increasing GO content and a dielectric constant (Dk) of 2.0 was achieved. This approach provides a strategy for developing ultrahigh performance GO–polymer composite materials.
ChemInform Abstract: The First General Enantioselective Catalytic Diels—Alder Reaction with Simple α,β‐Unsaturated Ketones. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Solving unsolved rare neurological diseases—a Solve-RD viewpoint (2021)

by clinical sites of to the RD-Connect Genome-Phenome Analysis Platform. Genomic data were processed and filtered as detailed The Solve-RD SNV/Indel working group reported back 74,456 variants in Members of the Solve-RD-DITF-RND and The Solve-RD Consortium are listed in below Acknowledgements.
Cell-Specific Imaging of Reporter Gene Expression Using a Two-Step Transcriptional Amplification Strategy (2010)

The monitoring of reporter gene expression allows measurement of the location(s), magnitude, and time variation of gene transcription in living animals and humans. Several imaging modalities can be employed for repetitive, noninvasive monitoring of reporter gene expression. The most common methods include positron emission tomography (PET), single photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), and optical imaging by bioluminescence (e.g., Firefly luciferase, Fluc, or luc) or fluorescence (e.g., green fluorescent protein, GFP). The strengths of each imaging modality are reviewed in Chapters 1–4. Noninvasive imaging has been applied extensively to monitor gene therapy, to detect cell migration and metastasis, and finally to monitor endogenous gene expression (by the use of transgenic mice expressing a reporter gene).
NO2 gas adsorption on titania-based nanotubes (2005)

TiO2‐based nanotubes were prepared using a hydrothermal technique and then investigated by high‐resolution TEM. Nanotubes were found to be hollow scrolls with a typical outer diameter of about 10 nm, inner diameter 4–5 nm and length of several hundred nm. The surface of nanotubes is found to be largely hydrolised. The presence of surface OH groups also determines their adsorption properties for the NO2 gas molecules. We demonstrate that TiO2 based nanotubes strongly adsorb NO2 molecules. Based on pulsed EPR experiments we suggest that the NO2 molecules couple with the nanotube surface via the nonbonding py orbital of the oxygen atoms.
Feedforward ANN for 2-1 fixed point ALUs (2002)

Investigates the possibility of constructing fixed point units using feedforward neural networks. The authors investigate the possibility of constructing small depth neural networks for operations usually defined in general purpose computer architectures. In particular the authors show that fixed operations require no more depth than the networks for binary addition. The authors show that depth-3 networks with bounded weights and small size requirements can be constructed that guarantee architectural compliance for fixed point arithmetic and address generation operations. Consequently, it is suggested that the proposed scheme can be used to potentially produce high performance arithmetic devices for fixed point processing units with small size requirements.
Application of total-reflection X-ray fluorescence spectrometry to elemental determinations in water, soil and sewage sludge samples (1991)

Total-reflection X-ray fluorescence (TXRF) spectrometry represents a relatively new instrumental analytical technique for the determination of trace elements in liquid samples. In this study, a range of sample types common to the water industry have been analysed for their elemental composition by TXRF and inductively coupled plasma (ICP) spectrometry. The TXRF method was found to offer, in general, lower limits of detection than are possible with ICP spectrometry, 4–5 orders of magnitude range in calibration, a sample preparation precision of <3% and an instrumental precision of <1%. Results obtained by TXRF compared favourably with those acquired by ICP and with the reference values that were available. Preparation of the digested and aqueous-based samples for TXRF analysis offered a very simple internal standard method for calibration and required only very small volumes (≈ 10 µl).
Solid-Phase Synthesis of Tetrasubstituted Pyrazoles, Novel Ligands for the Estrogen Receptor (2000)

Most ligands for the estrogen receptor (ER) are not well suited for synthesis by combinatorial means, because their construction involves a series of carbon-carbon bond forming reactions that are not uniformly high yielding. In previous work directed to overcoming this limitation, we surveyed various phenol-substituted five-membered heterocycles, hoping to find a system that would afford both high ER binding affinity and whose synthesis could be adapted to solid-phase methods (Fink et al. Chem. Biol. 1999, 6, 206-219.) In this report, we have developed a reliable and efficient solid-phase method to prepare the best of these heterocycles, the tetrasubstituted pyrazoles, and we have used this methodology to produce small, discrete libraries of these novel ER ligands. We used a combination of FT-IR and nanoprobe (1)H NMR-MAS to characterize intermediates leading up to the final pyrazole products directly on the bead. We also developed a scavenging resin, which enabled us to obtain products free from inorganic contaminants. We prepared a 12-member test library, and then a 96-member library, and in both cases we determined product purity and ER binding affinity of all of the library members. Several interesting binding affinity patterns have emerged from these studies, and they have provided us with new directions for further exploration, which has led to pyrazoles having high affinity and potency as agonists and antagonists toward the ER alpha subtype.
Synthesis of an Enantiomerically Pure Serine-Derived Thiazole (1996)

Previously reported methods for preparing enantiomerically pure thiazoles are inadequate for the synthesis of inherently labile O-alkyl serine-derived thiazoles. The intermediateN-Boc-(O-methylseryl) thiazolines are very susceptible to tautomerization, even under neutral conditions (Scheme 5). Herein, it is demonstrated that the choice of N-protecting group is critical to the preservation of enantiomeric purity. Thus, using an N-trityl protecting group, O-methyl serine was converted to the corresponding N-Boc-(O-methylseryl) thiazole 3 with no appreciable epimerization as indicated by (19)F and (1)H NMR of the corresponding Mosher's amide.
Red Dwarfs/Flare Stars (2000)

The red dwarf stars are main-sequence stars characterized by masses in the approximate range from 0.51M⊙ to 0.08M⊙. The upper mass limit corresponds to a spectral type of M0 V and the lower limit is the critical mass for the onset of nuclear burning in the central cores of stars with chemical abundances similar to the Sun. Below the range of approximately (0.074–0
NiV-C has a direct interaction with Tsg101. (2016)

&lt;p&gt;&lt;b&gt;(A)&lt;/b&gt; HA-tagged NiV-C co-immunoprecipitates endogenous Tsg101 from 293T cell lysates, as does HA-tagged Vps28, a known cellular interacting partner of Tsg101. &lt;b&gt;(B)&lt;/b&gt; NiV-C was truncated as indicated, with all constructs retaining a C-terminal HA tag. &lt;b&gt;(C)&lt;/b&gt; Loss of the CTD of NiV-C specifically leads to loss of pulldown of Tsg101. &lt;b&gt;(D)&lt;/b&gt; A fusion of EGFP and NiV-C-CTD (HA-EGFP-C-CTD) pulls down Tsg101, whereas EGFP alone does not. &lt;b&gt;(E)&lt;/b&gt; The C terminal domain (CTD) of Tsg101 was defined as in [&lt;a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005659#ppat.1005659.ref031" target="_blank"&gt;31&lt;/a&gt;]. FLAG-Tsg101 was truncated as indicated. UEV, ubiquitin E2 variant domain; PRO, proline-rich domain; CC, coiled-coil region; and CTD, C-terminal domain. &lt;b&gt;(F)&lt;/b&gt; Truncation of the CTD of Tsg101 results in loss of co-immunoprecipitation with NiV-C. &lt;b&gt;(G)&lt;/b&gt; A fusion of EGFP and the full CTD (amino acids 303–390) of Tsg101 (FLAG-EGFP-Tsg101-CTD) co-immunoprecipitates with NiV-C, whereas EGFP alone does not. &lt;b&gt;(H)&lt;/b&gt; &lt;i&gt;Left panel&lt;/i&gt;, Coomassie-stained gel showing recombinant proteins (100 ng each lane) purified from &lt;i&gt;E&lt;/i&gt;. &lt;i&gt;coli&lt;/i&gt; as described in Materials and Methods. &lt;i&gt;Right panel&lt;/i&gt;, Western analysis with repeat of Fig 5G except with purified recombinant proteins, showing that the interaction between NiV-C and Tsg101-CTD is direct.&lt;/p&gt;
A safe and interoperable distributed alarm notification system for PoC medical devices using IEEE 11073 SDC (2017)

The flood of alarms produced by Point-of-Care (PoC) medical devices in intensive care units (ICUs) and operating rooms (ORs) is a crucial issue of today's hospitals. Alarm fatigue and desensitization leads to the death of patients, noise worsens the patient's recovery process and causes burnout syndromes of caregivers, etc. Much research has been done in the last years to reduce false alarms and noise with smart and intelligent alarm systems. However, the situation has not improved. The developed systems are not used in the field, likely due to the “better-safe-than-sorry” mentality. Thus, we state that the first step to address alarm related problems is a safe and distributed system for alarm notifications. Therefore, we present mechanisms to generate alarm notifications safely at the place where they are needed by the caregivers, that is not necessarily the bedside. Our approach holds safety, risk management, and approval requirements. We use the new IEEE 11073 Service-oriented Device Connectivity (SDC) standard family. This ensures a safe interoperability of heterogeneous devices from multiple manufacturers, which is a major technical innovation, and makes the proposed system ready for future extensions like intelligent, computer-aided assistive systems. We therefore state that our mechanisms have a high potential to be used in the field and to improve clinical problems related to alarm notification systems. A demonstrator has been implemented for the proof of concept.
PHENANTHROLINE BASED METAL COMPLEXES AS G-QUADRUPLEX BINDING LIGANDS (2013)

Telomeric DNA present at the ends of chromosomes in normal somatic cells is progressively shortened after each cell replication, which eventually triggers cell death. In contrast, the length of telomeric DNA in cancer cells is maintained by over-expressed telomerase, a reverse transcriptase, making cancer cells immortal. Due to this apparent difference, telomerase has recently emerged as an attractive target for cancer intervention. One of the efficient approaches to inhibit the telomerase activity is to induce G-quadruplex formation in the telomeric DNA regions by small molecules to block the binding of telomerase. Such small molecules, known as G-quadruplex binding ligands, are being developed as potential anti-cancer drugs.
Supplementary Figure and Table Legends from EBV Is Necessary for Proliferation of Dually Infected Primary Effusion Lymphoma Cells (2023)

Supplementary Figure and Table Legends from EBV Is Necessary for Proliferation of Dually Infected Primary Effusion Lymphoma Cells
Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody (2014)

Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Here, we report the crystal structure of the IL-3 receptor α chain (IL3Rα) in complex with the anti-leukemia antibody CSL362 that reveals the N-terminal domain (NTD), a domain also present in the granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-5, and IL-13 receptors, adopting unique "open" and classical "closed" conformations. Although extensive mutational analyses of the NTD epitope of CSL362 show minor overlap with the IL-3 binding site, CSL362 only inhibits IL-3 binding to the closed conformation, indicating alternative mechanisms for blocking IL-3 signaling. Significantly, whereas "open-like" IL3Rα mutants can simultaneously bind IL-3 and CSL362, CSL362 still prevents the assembly of a higher-order IL-3 receptor-signaling complex. The discovery of open forms of cytokine receptors provides the framework for development of potent antibodies that can achieve a "double hit" cytokine receptor blockade.
Identification of Polo-like Kinase 1 inhibitors through phenotype-based approaches (2007)

A234 Polo-like Kinase 1 (PLK1) plays a key role in progression of mitosis. Currently, a lot of interest exists in identifying potent and selective inhibitors of PLK1 and developing them into cancer therapeutics. Down-regulation of Plk1 activity with siRNA or small molecules is characterized by inhibition of proliferation, cell cycle arrest in mitotis, apoptosis, and the so-called 9dumbbell9 morphology, in which post-mitotic cells have failed to separate via cytokinesis.  	We have screened a subset of Rigel compound library using an image-based high content screening (HCS) assay in double thymidine-synchronized tumor cells, and looked for the compounds that arrest cells at mitosis. Morphological information such as the pattern of DNA arrangement in mitosis-arrested cells, nuclear fragmentation (due to apoptosis or mitotic catastrophe) and “dumbbell” nuclei was assessed by visual inspection. We also monitored Plk1 activity in cells by Western blot and Phospho-flow assays based on detecting Cdc25C Ser-198 phosphorylation, a Plk1 specific target site.  	Combining image-based HCS with Plk1 cell-based assays we identified several hits. The anti-proliferative activity of these molecules in cells corresponds to the EC50 of PLK1 inhibition in cells (60-120nM). Phenotypes characteristic of PLK1 inhibition, including circular DNA arrangement in mitosis-arrested cells, apoptosis and dumbbell-shaped nuclei were observed upon incubation of cells with these compounds. In addition, in vitro kinase studies showed that at 100 nM PLK1 was fully inhibited by these compounds.  	Thus, a series of potent PLK1 inhibitors have been identified using a phenotype-based approach. SAR is currently being optimized to further improve potency and selectivity of lead molecules.
Aqueous Zinc‐Ion Batteries: Unraveling the Dissolution‐Mediated Reaction Mechanism of α‐MnO2 Cathodes for Aqueous Zn‐Ion Batteries (Small 48/2020) (2020)

In article number 2005406, Esther S. Takeuchi, Yimei Zhu, and co-workers demonstrate the dissolution-mediated reaction mechanism of Zn/α-MnO2 system for aqueous zinc-ion batteries via transmission electron microscopy. It involves α-MnO2 dissolution that activates the cell by inducing the reversible formation of Zn4SO4(OH)6·xH2O and ZnMn3O7·3H2O upon electrochemical cycling via (de-)insertion of Mn and Zn ions.
A new Methodology for Short Circuit Localization on Integrated Circuits using Magnetic Microscopy Technique Coupled with Simulations (2009)

This article shows how the magnetic technique can be improved to obtain more precise information about fault localization, particularly when other techniques cannot be used. We propose a new methodology based on the coupling of magnetic measurements with magnetic simulations, which we validate on a real case device.
Fusing short term and long term features for improved speaker diarization (2009)

The following article shows how a state-of-the-art speaker diarization system can be improved by combining traditional short-term features (MFCCs) with prosodic and other long-term features. First, we present a framework to study the speaker discriminability of 70 different long-term features. Then, we show how the top-ranked long-term features can be combined with short-term features to increase the accuracy of speaker diarization. The results were measured on standardized data sets (NIST RT) and show a consistent improvement of about 30% relative in diarization error rate compared to the best system presented at the NIST evaluation in 2007. This result was also verified on a wide set of meetings, which we call CombDev, that contains 21 meetings from previous evaluations. Since the prosodic and long-term features were selected using a diarization-independent speaker-discriminability study, we are confident that the same features are able to improve other systems that perform similar tasks
Gametic Selection by Glyphosate in Soybean Plants Hemizygous for the CP4 EPSPS Transgene (2005)

Glyphosate application to glyphosate‐tolerant soybean [ Glycine max (L.) Merr.] cultivars expressing a CP4 EPSPS transgene has become the most common method of soybean weed control in the USA. The objectives of this research were (i) to determine whether atypical segregation ratios for glyphosate tolerance and glyphosate sensitivity in the progeny of hemizygous plants resulted from gametic selection caused by glyphosate applications, (ii) to investigate the effects of different glyphosate application rates and timing of application on segregation ratios, and (iii) to determine whether male gametes, female gametes, or both were sensitive to the levels of glyphosate used. Segregation for glyphosate tolerance in a no‐glyphosate control treatment fit the expected 3:1 segregation ratio, indicating segregation of a single transgene. Glyphosate applications at three stages of plant development (V3, V3 + 2 to 3 wk, V3 + 3 to 4 wk) eliminated the glyphosate‐sensitive phenotypic class irrespective of plant maturation stage in a field experiment. Variations observed in the relative proportions of lines with either all‐tolerant or segregating phenotypic classes depended on glyphosate dosage and stage of plant development at the time of application. Overall, the data suggest that glyphosate application to hemizygous plants shortly before the onset of flowering was lethal to male gametes that do not carry the glyphosate tolerance transgene.
Negative feedback regulation of activated macrophages via Fas-mediated apoptosis (2000)

Apoptosis is a critical event for eliminating activated macrophages. Here we show that Fas-mediated apoptosis may participate in the mechanism of negative feedback regulation of activated macrophages. Cytokine-activated macrophages released high levels of nitric oxide (NO) that induced apoptosis in macrophages themselves. This NO-induced macrophage apoptosis was inhibited by a Fas-Fc chimeric molecule that binds to Fas ligand (FasL) and prevents its interaction with endogenous cell surface Fas. High levels of NO stimulated the release of the soluble form of FasL that was inhibited by a matrix metalloproteinase inhibitor KB-8301. High levels of NO also upregulated the expression of Fas mRNA in macrophages. In addition, macrophages isolated from Fas-lacking mice were resistant to NO-induced apoptosis. Finally, inhibition of apoptosis by a caspase inhibitor augmented peroxide production from activated macrophages. These findings suggest that high levels of NO released from activated macrophages may promote the Fas-mediated macrophage apoptosis that may be a negative feedback mechanism for elimination and the downregulation of activated macrophages in the vessel wall.
Prevention Surpasses Treatment: 5-year Follow-Up, Cost-Utility, and Cost–Benefit of Zeaxanthin Therapy for Neovascular Age-Related Macular Degeneration (2023)

ClinicalTrials.gov identifier, NCT01527435.