gebhart/patrepeval huggingface dataset:
Hardware Impairments Aware Transceiver Design for Full-Duplex Amplify-and-Forward MIMO Relaying (2017)

In this paper, we consider a full-duplex (FD) and amplify-and-forward (AF) relay with multiple antennas, where hardware impairments of the FD relay are taken into account. Due to the inter-dependence of the transmit relay power and the residual self-interference in an FD-AF relay, we observe a distortion loop that degrades the system performance when relay dynamic range is not high. In this paper, we analyze the relay function, and an optimization problem is formulated to maximize the signal to distortion-plus-noise ratio under relay and source transmit power constraints. Due to the problem complexity, we propose a gradient-projection-based (GP) algorithm to obtain an optimal solution. Moreover, a non-alternating sub-optimal solution is proposed by assuming a rank-1 relay amplification matrix, and separating the design of the relay process into multiple stages (MuStR1). The proposed MuStR1 method is then enhanced by introducing an alternating update over the optimization variables, denoted as AltMuStR1 algorithm. Numerical simulations show that compared to GP, the proposed (Alt)MuStR1 algorithms significantly reduce the required computational complexity at the expense of a slight performance degradation. Moreover, as the hardware impairments increase, or for a system with a high transmit power, the impact of applying a distortion-aware design is significant.
Creation of Brønsted acid sites on Sn-based solid catalysts for the conversion of biomass (2013)

Hydroxyl-attached Sn species are highly dispersed on the surface of mesoporous silica (SBA-15) by the grafting of dimethyldichlorostannane followed by calcination to transform the methyl groups into hydroxyl groups (S–Sn–OH). S–Sn–OH has both Lewis and Brønsted acidic sites, resulting in superior catalytic activities in the acetalisation of glycerol.
Function and expression of yeast mitochondrial NAD- and NADP-specific isocitrate dehydrogenases (1993)

The three isozymes of isocitrate dehydrogenase in Saccharomyces cerevisiae differ in subunit structure, subcellular location, and cofactor specificity. The two mitochondrial isozymes, IDH and IDP1, are NAD- and NADP-specific, respectively. Several lines of evidence presented here confirm the importance of IDH to respiratory processes. Expression of IDH RNA and protein is low with growth on glucose and is elevated with growth on non-fermentable carbon sources, a pattern of expression similar to that seen for other tricarboxylic acid cycle enzymes. In addition, a disruption mutant lacking IDH activity exhibits reduced growth rates on non-fermentable carbon sources, and mitochondria isolated from this mutant are incapable of respiration with added citrate. In contrast, IDP1 expression levels appear to be unresponsive to carbon source, and an IDP1 disruption mutant is not significantly impaired for growth or mitochondrial respiration. These results strongly suggest that IDP1 is incapable of participating in tricarboxylic acid cycle-based respiration despite its mitochondrial location. Analysis of the IDP1 and IDH disruption mutants for glutamate auxotrophy showed that either enzyme can contribute alpha-ketoglutarate for endogenous glutamate synthesis. IDH expression levels were found to be repressed in response to added glutamate during growth on glucose, while IDP1 expression levels remained unchanged. A double mutant lacking both IDP1 and IDH activities proved to be auxotrophic for glutamate during growth on glucose, but was capable of growth independent of added glutamate on non-fermentable carbon sources. These results suggest that the cytosolic NADP-specific IDP2 isozyme may provide alpha-ketoglutarate both for tricarboxylic acid cycle carbon flux and for cytosolic glutamate synthesis during growth on non-fermentable carbon sources in the absence of mitochondrial isocitrate dehydrogenase activity.
A Mild Synthetic Procedure for the Preparation of N‐Alkylated Sulfoximines. (2002)

Abstract For Abstract see ChemInform Abstract in Full Text.
Solution-Processed Chloroaluminum Phthalocyanine (ClAlPc) Ammonia Gas Sensor with Vertical Organic Porous Diodes (2021)

In this research work, the gas sensing properties of halogenated chloroaluminum phthalocyanine (ClAlPc) thin films were studied at room temperature. We fabricated an air-stable ClAlPc gas sensor based on a vertical organic diode (VOD) with a porous top electrode by the solution process method. The surface morphology of the solution-processed ClAlPc thin film was examined by field emission scanning electron microscopy (FESEM) and atomic force microscopy (AFM). The proposed ClAlPc-based VOD sensor can detect ammonia (NH<sub>3</sub>) gas at the ppb level (100~1000 ppb) at room temperature. Additionally, the ClAlPc sensor was highly selective towards NH<sub>3</sub> gas compared to other interfering gases (NO<sub>2</sub>, ACE, NO, H<sub>2</sub>S, and CO). In addition, the device lifetime was tested by storing the device at ambient conditions. The effect of relative humidity (RH) on the ClAlPc NH<sub>3</sub> gas sensor was also explored. The aim of this study is to extend these findings on halogenated phthalocyanine-based materials to practical electronic nose applications in the future.
AFGL (Air Force Geophysical Laboratory) atmospheric constituent profiles (0. 120km). Environmental research papers (1986)

An atmospheric data base consisting of volume-mixing ratios (o0 to 12 okm) for 28 minor and trace gases was assembled for use with spectral-radiance transmittance models. Six reference atmospheres, each defining temperature, pressure and density as a function of altitude (selected from the U.S. Standard Supplements, 1966 and the U.S. Standard Atmosphere, 1976) provide a range of climatological choices. Analogous zonal-mean descriptions for H/sub 2/O, O/sub 3/, N/sub 2/O, CO, and CH/sub 4/ were subsequently adapted from satellite data and/or dynamical-photochemical analyses. The remaining species are defined by single profiles, usually appropriate for U.S. Standard conditions. Because the entire profile set is preferentially based on available measurements, explicit photochemical consistency between the different species has not been maintained.
Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure–Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis (2016)

6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazole derivatives were initially studied for tuberculosis within a backup program for the clinical trial agent pretomanid (PA-824). Phenotypic screening of representative examples against kinetoplastid diseases unexpectedly led to the identification of DNDI-VL-2098 as a potential first-in-class drug candidate for visceral leishmaniasis (VL). Additional work was then conducted to delineate its essential structural features, aiming to improve solubility and safety without compromising activity against VL. While the 4-nitroimidazole portion was specifically required, several modifications to the aryloxy side chain were well-tolerated e.g., exchange of the linking oxygen for nitrogen (or piperazine), biaryl extension, and replacement of phenyl rings by pyridine. Several less lipophilic analogues displayed improved aqueous solubility, particularly at low pH, although stability toward liver microsomes was highly variable. Upon evaluation in a mouse model of acute Leishmania donovani infection, one phenylpyridine derivative (37) stood out, providing efficacy surpassing that of the original preclinical lead.
Metabolism of carveol and dihydrocarveol in Rhodococcus erythropolis DCL14 (2000)

Rhodococcus erythropolis DCL14 assimilates all stereoisomers of carveol and dihydrocarveol as sole source of carbon and energy. Induction experiments with carveol- or dihydrocarveol-grown cells showed high oxygen consumption rates with these two compounds and with carvone and dihydrocarvone. (Dihydro)carveol-grown cells of R. erythropolis DCL14 contained the following enzymic activities involved in the carveol and dihydrocarveol degradation pathways of this micro-organism: (dihydro)carveol dehydrogenase (both NAD+- and dichlorophenolindophenol-dependent activities), an unknown cofactor-dependent carvone reductase, (iso-)dihydrocarvone isomerase activity, NADPH-dependent dihydrocarvone monooxygenase (Baeyer-Villiger monooxygenase), epsilon-lactone hydrolase and an NAD+-dependent 6-hydroxy-3-isopropenylheptanoate dehydrogenase. Product accumulation studies identified (4R)-carvone, (1R,4R)-dihydrocarvone, (4R,7R)-4-isopropenyl-7-methyl-2-oxo-oxepanone, (3R)-6-hydroxy-3-isopropenylheptanoate, (3R)-3-isopropenyl-6-oxoheptanoate, (3S,6R)-6-isopropenyl-3-methyl-2-oxooxepanone and (5R)-6-hydroxy-5-isopropenyl-2-methylhexanoate as intermediates in the (4R)-carveol degradation pathway. The opposite stereoisomers of these compounds were identified in the (4S)-carveol degradation pathway. With dihydrocarveol, the same intermediates are involved except that carvone was absent. These results show that R. erythropolis DCL14 metabolizes all four diastereomers of carveol via oxidation to carvone, which is subsequently stereospecifically reduced to (1R)-(iso-) dihydrocarvone. At this point also dihydrocarveol enters the pathway, and this compound is directly oxidized to (iso-)dihydrocarvone. Cell extracts contained both (1R)-(iso-)dihydrocarvone 1,2-monooxygenase and (1S)-(iso)-dihydrocarvone 2,3-monooxygenase activity, resulting in a branch point of the degradation pathway; (1R)-(iso-)dihydrocarvone was converted to 4-isopropenyl-7-methyl-2-oxo-oxepanone, while (1S)-(iso)-dihydrocarvone, which in vivo is isomerized to (1R)-(iso-)dihydrocarvone, was converted to 6-isopropenyl-3-methyl-2-oxo-oxepanone. 4-Isopropenyl-7-methyl-2-oxooxepanone is hydrolysed to 6-hydroxy-3-isopropenylheptanoate, which is subsequently oxidized to 3-isopropenyl-6-oxoheptanoate, thereby linking the (dihydro)carveol degradation pathways to the limonene degradation pathway of this micro-organism. 6-Isopropenyl-3-methyl-2-oxo-oxepanone is, in vitro, hydrolysed to 6-hydroxy-5-isopropenyl-2-methylhexanoate, which is thought to be a dead-end metabolite.
The Latest Trend of Micro TAS Technology (2011)

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A multidisciplinary total hip arthroplasty protocol with accelerated postoperative rehabilitation: does the patient benefit? (2014)

Since its debut over 10 years ago, minimally invasive total hip arthroplasty (THA) has often been associated with accelerated postoperative rehabilitation when compared with THA performed with a traditional surgical approach. The objective of this study was to investigate the effect of accelerated postoperative rehabilitation and early mobilization on length of stay and hospital readmissions in patients undergoing THA at one institution. We retrospectively reviewed a consecutive series of 590 patients who underwent THA between January 31, 2011 and April 30, 2011. Six arthroplasty surgeons using varying surgical techniques participated. One hundred ninety patients received accelerated rehabilitation and were mobilized on the day of surgery. The remaining 400 patients were mobilized on postoperative day one (POD1). Length of stay for the accelerated rehabilitation group was 2.06 days and 3.38 days for the standard group. One patient was readmitted to the hospital within 30 days (.52%) in the accelerated group compared to 19 re-hospitalizations (4.72%) in the POD1 group. Ninety-six percent of the accelerated group were discharged home versus 62% in POD1 group. Our results support the use of an accelerated rehabilitation protocol at one institution following total hip replacement surgery.
Longitudinal multiparameter single-cell analysis of macaques immunized with pneumococcal protein-conjugated or unconjugated polysaccharide vaccines reveals distinct antigen specific memory B cell repertoires (2017)

Our results confirm that distinctive differences can manifest between antigen-specific memory B cell repertoires in nonhuman primates immunized with conjugated and unconjugated pneumococcal polysaccharide vaccines. The study also supports the notion that the conjugated vaccines have a favorable profile in terms of both the frequency and breadth of the anamnestic response among antigen-specific memory B cells.
The role of immunological tolerance in humoral responses to the 2F5 epitope of HIV-1 (P6183) (2013)

Abstract Many human antibodies (Ab), e.g., 2F5, that neutralize multiple clades of HIV-1 are self-reactive. We previously identified kynureninase (KYNU) as the primary self-antigen recognized by 2F5, suggesting that generation of Ab to the 2F5 epitope of HIV-1 may be proscribed by immune tolerance, a notion supported by impaired B-cell development in mice expressing the 2F5 VH and VL regions (2F5 KI). Here, we use Nojima-Kitamura single B-cell cultures to determine the pre- and post-tolerance Ab repertoire to HIV-1. All cultured B cells differentiate into IgG-secreting cells, including autoreactive cells normally subject to tolerization in vivo. The pre-tolerance compartment (small pre-B) from 2F5 KI mice represents cells that express the 2F5 V(D)J rearrangements, and maintain reactivity to HIV-1 gp41, KYNU, and cardiolipin. Mature, post-tolerance B cells from 2F5 KI mice, however, are purged of gp41- and KYNU-reactivity, but retain cardiolipin-binding, and sequence analysis reveals extensive light-chain editing. This loss of HIV-reactivity is followed in unmodified C57BL/6 mice, where B cells expressing 2F5-like BCR are lost during maturation in the bone marrow, as determined by binding to 2F5 epitope. Our results demonstrate that tolerance of the 2F5 epitope is driven by specific reactivity to KYNU, but not general cross-reactivity to cardiolipin and offer a mechanism for determining how immunological tolerance impairs humoral responses to HIV-1.
ChemInform Abstract: Aureolic Acid Antibiotics: Synthesis of the Cyclohexenone Segment from D‐Glucose. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
[P‐107]: Quantifying T1‐rho in Alzheimer's disease (2005)

Conventional MRI techniques have proven inadequate in observing the underlying pathology of Alzheimer's Disease (AD) in humans in vivo. In previous studies, differences in T2 relaxation times could not discern between patient and control populations. The spin-lattice relaxation time constant in the rotating frame, or T1ρ, is an alternate contrast mechanism. Whereas quantifying T2* with MRI can be prone to errors from susceptibility-induced signal losses and the T2-weighted MR signal is degraded by diffusion, T1ρ-weighted MR images are not affected by any such losses and T1ρ typically has a greater dynamic range than T2* or T2 in biological tissues. T1ρ-weighted MRI has been shown to generate tissue contrast based on variations in protein content. To determine whether there are any changes in T1ρ relaxation times in patients with AD compared to age-matched controls. MRI was performed on 7 patients (mean age:77±7) with AD (diagnosed by a neurologist) and 5 controls (mean age:73±7) on a Siemens Sonata 1.5 Tesla clinical scanner. T1ρ-weighted image of a slice perpendicular to the AC/PC plane was obtained and included the head of the hippocampus. A T1ρ pre-encoded Turbo Spin-Echo pulse sequence was employed with TE/TR=12/2000ms, TSL(duration of spin-lock pulse)= 20, 40, 60 and 80ms, slice thickness=2mm, 860μm pixel-size, for a total imaging time of 6 minutes for four images. Each pixel's signal intensity was fitted as a function of TSL by a linear least-squares algorithm to generate T1ρ maps. A region of interest was manually selected in the parenchyma in the right medial temporal lobe and average T1ρ values recorded. A student's t-test was performed to determine any significance in the difference in T1ρ values between groups. Average T1ρ for the AD group was 95.3±1.4ms (mean± std. error) and for controls was 87.5±1.7ms and the difference was statistically significant (p<0.005). Typical T1ρ MR images (grayscale images) and corresponding T1ρ maps (color images) are shownin the figure. This is the first demonstration of imaging AD pathology in humans using T1ρ imaging. Our results indicate that clinically-confirmed AD results in the prolongation of T1ρ relaxation time in brain tissue.
Sincronoscopio Virtual para un Sistema Multimáquina de Laboratorio de Sistemas Eléctricos de Potencia (2015)

Resumen: Este trabajo tiene como objetivo la construcción de un sincronoscopio virtual para un sistemamultimáquina del laboratorio de sistemas eléctricos de potencia de la Escuela Politécnica Nacional, utilizando comodispositivos de adquisición de datos las tarjetas NI USB 6008 de National Instruments, las cuales utilizan laplataforma NI LabVIEW para procesar, analizar y visualizar las variables eléctricas en una interfaz gráfica (HMI).El instrumento tiene la capacidad de realizar la sincronización de máquinas verificando voltajes de línea,frecuencias, secuencias de fases y voltaje diferencial, así como medir potencia activa, reactiva, aparente, y factorde potencia de un sistema multimáquina. Abstract: This work is aimed at building a virtual synchroscope for a multimachine system of the electrical powersystem laboratory at the National Polytechnic School, using as data acquisition device a NI USB 6008 card fromNational Instruments, which uses the NI platform LabVIEW to process, analyze and display the electrical variablesin a Human-Machine Interface (HMI). This instrument allows to synchronizemachines by verifying line voltages,frequencies, phase sequences and differential voltage, as well as measure of active, reactive, apparent power andpower factor of a multimachinesystem.
Improving the Rate-distortion Model of HEVC Intra by Integrating the Maximum Absolute Error (2019)

Normally, the mean squared error in conjunction with the rate is used to optimize the compression in hybrid video coding. However, in some areas, such as medical image coding, not only the average error but also the maximum error should be considered. Recently, it has been shown that incorporating the maximum absolute error into the calculation of the rate-distortion optimization (RDO) of the HEVC encoder can improve image quality, while preserving the average error and the rate. In this paper, we optimize the inclusion of the maximum absolute error in the RDO by considering the whole quantization parameter range as well as the different prediction unit sizes. Compared to the existing extended RDO, up to 1.5 % bitrate can be saved for the same maximum absolute error reduction.
Immunoassay detection of drugs in racing horses. IV. Detection of fentanyl and its congeners in equine blood and urine by a one step ELISA assay. (1988)

We have developed and evaluated a one step enzyme-linked immunosorbent assay (ELISA) test for fentanyl as part of a panel of pre- and post-race tests for narcotic analgesics in racing horses. This ELISA test detects fentanyl with an I-50 of about 100 pg/ml. The test is economical in that it can be read with an inexpensive spectrophotometer, or even by eye. The test is rapid, and ten samples, a normal pre-race complement, can be analyzed in about twenty minutes. The test readily detects the presence of fentanyl or its metabolites in equine blood and urine from two and twenty-four hours respectively after administration of sub-therapeutic doses. The two antibodies evaluated also cross-react with the methylated analogs of fentanyl, sufetanil and carfentanil and the test detected these drugs shortly after their administration to horses. When introduced into routine screening, this test, in combination with another immunoassay test previously described, yielded 10 sufentanil positives. As such this test is capable of both improving the quality and reducing the cost of pre-race and post-race testing for fentanyl and a number of its congeners in racing horses.
Spectrin St Claude, a Splicing Mutation of the Human α-Spectrin Gene Associated With Severe Poikilocytic Anemia (1997)

An alpha-spectrin variant with increased susceptibility to tryptic digestion, alpha(II/47), was previously observed in a child with severe, recessively inherited, poikilocytic anemia. The molecular basis of this variant, spectrin St Claude, has now been identified as a splicing mutation of the alpha-spectrin gene due to a T --> G mutation in the 3' acceptor splice site of exon 20. This polypyrimidine tract mutation creates a new acceptor splice site, AT --> AG, and leads to the production of two novel mRNAs. One mRNA contains a 12 intronic nucleotide insertion upstream of exon 20. This insertion introduces a termination codon into the reading frame and is predicted to encode a truncated protein (108 kD) that lacks the nucleation site and thus cannot be assembled in the membrane. In the other mRNA, there is in-frame skipping of exon 20, predicting a truncated (277 kD) alpha-spectrin chain. The homozygous propositus has only truncated 277 kD alpha-spectrin chains in his erythrocyte membranes. His heterozygous parents are clinically and biochemically normal. This allele was identified in 3% of asymptomatic individuals from Benin, Africa.
Reduction of initial stress stiffening by topology optimization (2012)

Topology optimization is a rigorous method of obtaining non-intuitive designs. We use it to obtain a capacitive RF switch that stiffens little in response to an increase of the in-plane biaxial stresses that typically develop during MEMS fabrication. The actuation voltage is closely related to the membrane's stiffness, and is more stable for a stress insensitive switch. We employ the Solid Isotropic Material with Penalization (SIMP) method with the Method of Moving Asymptotes (MMA) and a robust formulation to minimize the ratio between the compliance at a low stress level and that at a high stress level. We include a volume constraint and a compliance constraint. Topology optimized designs are compared to an intuitively-designed RF switch. The switches contain similar features. The compliance constraint is varied such that the topology optimized switch performance approaches the intuitively-designed one. Finally, the importance of the compliance constraint and of the robust formulation are discussed.
Synthesis and Catalytic Performance of Hierarchically Porous MIL-100(Fe)@polyHIPE Hybrid Membranes (2015)

Metal-organic frameworks (MOFs) nanoparticles in combination with a nonionic surfactant (Pluronic L-121) are used to stabilize dicyclopentadiene (DCPD)-in-water high internal phase emulsions (HIPEs). The resulting HIPEs containing the MIL-100(Fe) nanoparticles (MIL: Materials of Institut Lavoisier) at the interface between the oil- and the water-phases are then cured, and 100 μm thick, fully open, hierarchically porous hybrid membranes are obtained. The properties of the MIL-100(Fe)@pDCPD polyHIPE membranes are characterized and it is found that up to 14 wt% of the MIL-100(Fe) nanoparticles are incorporated in the hybrid material resulting in an increase of the microporosity up to 130 m(2) g(-1). Hybrid membranes show an appealing catalytic activity in Friedel-Crafts alkylation in a batch mode as well as in a flow-through mode, thereby demonstrating the preserved accessibility of Lewis acidic sites in the MOF nanostructures.