gebhart/patrepeval huggingface dataset:
Deuterium-Labeled Precursor Feeding Reveals a New pABA-Containing Meroterpenoid from the Mango Pathogen Xanthomonas citri pv. mangiferaeindicae (2016)

A new para-aminobenzoic-acid-containing natural product from the mango pathogenic organism Xanthomonas citri pv. mangiferaeindicae is described. By means of stable isotope precursor feeding combined with nontargeted LC-MS/MS, the generated spectra were clustered and visualized in a molecular network. This led to the identification of a new member of the meroterpenoids, termed xanthomonic acid, which is composed of an isoprenylated para-aminobenzoic acid. In vitro cytotoxicity assays demonstrated activity of xanthomonic acid against several human cancer cell lines by induction of autophagy.
Nitric oxide synthase type I and type III gene expression are developmentally regulated in rat lung (1994)

The successful transition from fetal to neonatal life involves a marked decline in pulmonary vascular resistance which is modulated in part by endothelium-derived nitric oxide. To define the molecular processes which prepare the pulmonary circulation for nitric oxide mediation of vasodilatation at the time of birth, we determined the ontogeny of endothelial nitric oxide synthase (NOS-III) gene expression in lungs from fetal and newborn rats. Maturational changes in lung neuronal NOS (NOS-I) expression were also investigated; the latter isoform has been localized to rat bronchiolar epithelium. NOS proteins were examined by immunoblot analysis, and mRNA abundance was assessed in reverse transcription-polymerase chain reaction assays. Both NOS-III and NOS-I protein were detectable in 16-day fetal lung, they increased 3.8- and 3.1-fold, respectively, to maximal levels at 20 days of gestation (term = 22 day), and they fell postnatally (1-5 days). In parallel with the findings for NOS-III protein, NOS-III mRNA increased from 16 to 20 days gestation and fell after birth. In contrast, NOS-I mRNA abundance declined during late fetal life and rose postnatally. These findings were confirmed by Northern analyses. Thus NOS-III and NOS-I gene expression are developmentally regulated in rat lung, with maximal NOS-III and NOS-I protein present near term. The regulation of pulmonary NOS-III may primarily involve alterations in transcription or mRNA stability, whereas NOS-I expression in the maturing lung may also be mediated by additional posttranscriptional processes.
ChemInform Abstract: SYNTHESIS OF SPIROFLUORENES OF BIOLOGICAL INTEREST (1978)

Abstract Das Anhydrid (I) liefert bei der Umsetzung mit primären Aminen (II) die Spiropyrrolidindione (III).
Arthroscopic Repair of Massive “Irreparable” Tears of the Rotator Cuff Using Double Interval Slides: Clinical And Magnetic Resonance Imaging Results (SS‐43) (2008)

The objective of this study was to examine the clinical and anatomical outcomes following arthroscopic double interval slides in the repair of massive, otherwise “irreparable” rotator cuff tears. 11 patients were evaluated clinically and with MRI at a minimum 12 months post-operative. Double interval slides resulted in improved shoulder specific quality of life scores (post-operative versus pre-operative) and improved forward flexion. Active external rotation demonstrated no significant change. Anatomically, 55% of patients demonstrated massive re-tearing on MRI, 18% demonstrated a thin though grossly intact repair, and 27% showed a robust repair.
Neuroprotective effects of a dendrimer-based glutamate carboxypeptidase inhibitor on superoxide dismutase transgenic mice after neonatal hypoxic-ischemic brain injury (2020)

The result of a deprivation of oxygen and glucose to the brain, hypoxic-ischemic encephalopathy (HIE), remains the most common cause of death and disability in human neonates globally and is mediated by glutamate toxicity and inflammation. We have previously shown that the enzyme glutamate carboxypeptidase (GCPII) is overexpressed in activated microglia in the presence of inflammation in fetal/newborn rabbit brain. We assessed the therapeutic utility of a GCPII enzyme inhibitor called 2-(3-Mercaptopropyl) pentanedioic acid (2MPPA) attached to a dendrimer (D-2MPPA), in order to target activated microglia in an experimental neonatal hypoxia-ischemia (HI) model using superoxide dismutase transgenic (SOD) mice that are often more injured after hypoxia-ischemia than wildtype animals. SOD overexpressing and wild type (WT) mice underwent permanent ligation of the left common carotid artery followed by 50 min of asphyxiation (10% O<sub>2</sub>) to induce HI injury on postnatal day 9 (P9). Cy5-labeled dendrimers were administered to the mice at 6 h, 24 h or 72 h after HI and brains were evaluated by immunofluorescence analysis 24 h after the injection to visualize microglial localization and uptake over time. Expression of GCPII enzyme was analyzed in microglia 24 h after the HI injury. The expression of pro- and anti-inflammatory cytokines were analyzed 24 h and 72 h post-HI. Brain damage was analyzed histologically 7 days post-HI in the three randomly assigned groups: control (C); hypoxic-ischemic (HI); and HI mice who received a single dose of D-2MPPA 6 h post-HI (HI+D-2MPPA). First, we found that GCPII was overexpressed in activated microglia 24 h after HI in the SOD overexpressing mice. Also, there was an increase in microglial activation 24 h after HI in the ipsilateral hippocampus which was most visible in the SOD+HI group. Dendrimers were mostly taken up by microglia by 24 h post-HI; uptake was more prominent in the SOD+HI mice than in the WT+HI. The inflammatory profile showed significant increase in expression of KC/GRO following injury in SOD mice compared to WT at 24 and 72 h. A greater and significant decrease in KC/GRO was seen in the SOD mice following treatment with D-2MPPA. Seven days after HI, D-2MPPA treatment decreased brain injury in the SOD+HI group, but not in WT+HI. This reduced damage was mainly seen in hippocampus and cortex. Our data indicate that the best time point to administer D-2MPPA is 6 h post-HI in order to suppress the expression of GCPII by 24 h after the damage since dendrimer localization in microglia is seen as early as 6 h with the peak of GCPII upregulation in activated microglia seen at 24 h post-HI. Ultimately, treatment with D-2MPPA at 6 h post-HI leads to a decrease in inflammatory profiles by 24 h and reduction in brain injury in the SOD overexpressing mice.
Mechanical Manipulator for Intuitive Control of Endoscopic Instruments With Seven Degrees of Freedom (2004)

Performing complex tasks such as vascular anastomosis in minimally invasive surgery (MIS) is demanding due to a disturbed hand-eye co-ordination, the application of non-ergonomic instruments with limited number of degrees of freedom (DOFs) and a lack of three-dimensional perception. Robotic tele-manipulatory systems enhance surgical dexterity by providing up to seven DOFs. They allow the surgeon to operate in an ergonomically favourable position with more intuitive manipulation of the instruments. Robotic systems, however, are very bulky, expensive and do not provide any force feedback from the tissue. The aim of our study is to develop a simple mechanical manipulator for MIS. The Minimally Invasive Manipulator (MIM) is a purely mechanical device. When manipulating the handle of the MIM, the surgeon's wrist and grasping movements, which are essential for suturing, are directly transmitted to the deflectable instrument tip in seven DOFs. It gives the surgeon direct control of the instrument tip. First phantom experience indicates that the system functions properly. The MIM provides force feedback to improve safety. A set of MIMs seems to be an economical and compact alternative to robotic systems and will offer more surgeons the capability to perform complex MIS and to shorten their learning curve.
Leptin Modulates Innate and Adaptive Immune Cell Recruitment after Cigarette Smoke Exposure in Mice (2010)

Leptin, a pleiotropic type I cytokine, was recently demonstrated to be expressed by resident lung cells in chronic obstructive pulmonary disease patients and asymptomatic smokers. To elucidate the functional role of leptin in the onset of chronic obstructive pulmonary disease, we tested leptin-deficient ob/ob mice (C57BL/6), leptin receptor-deficient db/db mice (C57BKS), and littermates in a model of cigarette smoke (CS)-induced pulmonary inflammation. Wild-type (WT) C57BL/6 mice were exposed for 4 or 24 wk to control air or CS. Pulmonary leptin expression was analyzed by immunohistochemistry and real-time PCR. Pulmonary inflammation upon 4 wk CS exposure was evaluated in bronchoalveolar lavage fluid (BALF) and lung tissue of WT, ob/ob, and db/db mice. Immunohistochemical analysis revealed leptin expression in bronchial epithelial cells, pneumocytes, alveolar macrophages, and bronchial/vascular smooth muscle cells. The 4 and 24 wk CS exposure increased leptin expression in bronchial epithelial cells and pneumocytes versus air-exposed WT mice (p<0.05). The 4 wk CS exposure resulted in increased accumulation of neutrophils, dendritic cells, macrophages, and lymphocytes in BALF and lung tissue of WT, ob/ob, and db/db mice. CS-exposed ob/ob and db/db mice showed in general higher numbers of neutrophils and lower numbers of CD4+, CD8+, and dendritic cells versus CS-exposed WT mice. Consistently, CXCL1 levels were enhanced in BALF of CS-exposed ob/ob and db/db mice versus WT mice (p<0.05). Exogenous leptin administration completely restored the skewed inflammatory profile in ob/ob mice. These data reveal an important role of leptin in modulating innate and adaptive immunity after CS inhalation in mice.
R-Dependency of the Hardness of Perovskite-Type RRh3B Compounds (R = La, Gd, Lu and Sc) (2001)

Perovskite-type rare-earth rhodium borides of the chemical formula RRh 3 B (R=La, Gd, Lu and Sc) have been studied from the viewpoint of microhardness. Polycrystals of RRh 3 B are synthesized by the arc melting method. RRh 3 B compounds have a perovskite-type cubic structure (space group: P m 3 m ). The microhardness become larger with the contraction of the volume of the Rh 6 B octahedron in the perovskite-type structure. As a result, microhardness increases with decreasing atomic size of R in RRh 3 B.
Application of novel catalysts: general discussion (2016)

Elad Gross opened the discussion of the paper by Simon Kondrat: What are the surface properties of the perovskite materials that you used in your study? Are the surface and catalytic properties of Cr or Mn based perovskites similar to those of CrOx or MnOx? Simon Kondrat answered
Molecular layer perforant path-associated cells contribute to feed-forward inhibition in the adult dentate gyrus (2013)

New neurons, which have been implicated in pattern separation, are continually generated in the dentate gyrus in the adult hippocampus. Using a genetically modified rabies virus, we demonstrated that molecular layer perforant pathway (MOPP) cells innervated newborn granule neurons in adult mouse brain. Stimulating the perforant pathway resulted in the activation of MOPP cells before the activation of dentate granule neurons. Moreover, activation of MOPP cells by focal uncaging of glutamate induced strong inhibition of granule cells. Together, these results indicate that MOPP cells located in the molecular layer of the dentate gyrus contribute to feed-forward inhibition of granule cells via perforant pathway activation.
Privacy-Preserving Text Classification on BERT Embeddings with Homomorphic Encryption (2022)

Garam Lee, Minsoo Kim, Jai Hyun Park, Seung-won Hwang, Jung Hee Cheon. Proceedings of the 2022 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies. 2022.
Diagnosis of Renal Proximal Tubular Injury by Urinary Immunoassay for a Proximal Tubular Antigen, the Adenosine Deaminase Binding Protein (1987)

A sandwich ELISA assay has been formatted from two commercially available murine monoclonal antibodies, URO-4 and URO-4a, directed against a 120,000 dalton glycoprotein, the adenosine deaminase binding protein (ABP), found on the brush border of the renal proximal tubular epithelial cell. Untimed urine samples from 37 normal individuals and urinary ABP less than 0.1 AU; 37 patients with pure glomerular disease had ABP less than 0.4 AU (with 29, or 76% less than 0.2 AU); 10 patients with pre-renal azotaemia had ABP less than 0.6 (with 8, or 80% less than 0.3 AU). In contrast, 79 patients with post-ischaemic acute tubular necrosis had ABP greater than 0.6 AU. Acute renal failure due to myoglobinuria, contrast dye, and aminoglycoside toxicity were all associated with urinary ABP greater than 1.0 AU. In addition, all six patients with acute bacteraemic pyelonephritis had ABP greater than 0.7 AU, as opposed to ABP less than 0.2 AU in the urines of 12 women with acute cystitis. We conclude that this monoclonal antibody based urinary assay is a sensitive measure of renal proximal tubular injury, reliably distinguishes acute tubular from glomerular disease, and may be helpful in differentiating forms of urinary tract infection.
Statistics of the sum of lognormal variables in wireless communications (2002)

Schwartz and Yeh's method (1982) and Wilkinson's method are widely used to compute the moments of the total co-channel interference in wireless communication, usually modeled as the sum of lognormal random variables. The accuracy of these methods has been studied in previous works, under the assumption of having all summands signals (individual interference signals) identically distributed. Such assumption rarely holds in practical cases of emerging wireless systems, where interference may stem from far-away macrocells and nearby transmitters, causing the interference signals to have different moments. In this paper we present an analysis of Wilkinson's method and Schwartz and Yeh's method, for the general case when the summands have different mean values and standard deviations in decibel units. We show that Schwartz and Yeh's method provides better accuracy than Wilkinson's method and is virtually invariant with the difference of the mean values and standard deviations of the summands, and the number of summands.
A Residual Marker of Cognitive Reserve Is Associated with Resting-State Intrinsic Functional Connectivity Along the Alzheimer’s Disease Continuum (2023)

Our results provide evidence that INC is associated with CRM in ADN defined as participants with amyloid pathology with or without cognitive symptoms, suggesting that the neural correlates of CR are mirrored in network FC in resting-state.
Seven Years of Vitrified Blastocyst Transfers: Comparison of 3 Preparation Protocols at a Single ART Center (2020)

<b>Introduction:</b> Frozen-thawed embryo transfers (FET) have become a standard practice to increase cumulative pregnancy rates, however, the choice of the best preparation protocol remains a matter of debate. <b>Design:</b> Retrospective analysis of clinical pregnancy (CPR) and live birth rate (LBR) of FET in natural cycles (NC-FET), modified natural cycles with hCG-triggered ovulation (mNC-FET), and hormonal artificial replacement (AR-FET). <b>Materials and Methods:</b> For natural cycles, patients were monitored by ultrasound to evaluate the dominant follicle and by urinary LH kits (NC-FET). When the endometrial thickness reached at least 7 mm and the dominant follicle 16-20 mm, hCG was administered in absence of urinary LH surge (mNC-FET). Embryo thawing and transfer was planned 7 days after LH surge or hCG administration. For the AR-FET, oral estradiol valerate was administered from day 2 of menstrual cycle until endometrial thickness reached at least 7 mm and transfer was planned after 5 days of vaginal progesterone start. Only single vitrified blastocyst transfers were included. <b>Results:</b> In total 2,895 transfers were performed of which 561 (19.4%) carried out with NC-FET, 1,749 (60.4%) with mNC-FET and 585 (20.2%) with AR-FET. CPRs were 32.62, 43.05, and 37.26%, respectively. LBR were 24.06, 33.56, and 25.81%, respectively. A statistically significant (<i>p</i> < 0.001) higher LBR for mNC-FET vs. NC-FET (OR 0.49-0.78) and AR-FET (OR 0.47-0.74) was observed. A higher ectopic pregnancy rate (<i>p</i> = 0.002) was observed in NC-FET (3.28%) than in AR-FET (1.83%) and mNC-FET (0.40%). A higher abortion rate (<i>p</i> = 0.031) in pregnancies <12 weeks was observed in AR-FET (27.52%) than in NC-FET (19.67%) and in mNC-FET (19.39%). At <i>Post hoc</i> analysis only female age (OR 0.91-0.95), antimullerian hormone (AMH) (OR 1.01-1.07) and mNC-FET (OR 1.39-1.98) were statically significant prognostic factors for LBRs. <b>Conclusions:</b> These results demonstrate a superior CPR and LBR following FET in hCG-triggered ovulation cycles compared to NC and AR-FET, a higher ectopic pregnancy rate in NC-FET and a higher abortion rate in pregnancies <12 weeks in AR-FET. However, these data need to be confirmed in randomized and prospective studies before definitive conclusions can be drawn. <b>Clinicaltrials.gov ID: NCT03581422</b>.
Oxygen Scavenging and Oxygen Barrier Poly(1,2‐butadiene) Films Containing an Iron‐Complex Catalyst (2019)

Abstract Tough films of poly(1,2‐butadiene) are prepared by introducing small amounts of the less toxic iron complex N , N ′‐bis(salicylidene)ethylenediamine‐benzylimidazole and methyl linoleate. The catalytic activity of the iron complex for air oxidation of unsaturated groups is substantially higher than those of previously reported films. The oxygen scavenging capacity of the films is up to 200 mL (oxygen gas at STP) g(film) −1 after 1 month, based on oxidative consumption of the poly(1,2‐butadiene) double bonds, which is more than twice that of a previously reported poly(1,4‐butadiene) film containing a cobalt complex catalyst and a film containing reduced iron powder. The oxygen absorption and scavenging of the films is independent of humidity and is maintained over 1 month. The results suggest that the combination of poly(1,2‐butadiene) and the iron complex catalyst is a promising oxygen scavenging material for active oxygen barrier films.
Single-dot spectroscopy of multiexcitons in AlInAs/AlGaAs quantum dots (2000)

Self-assembled AI36Ino.As/AIo33Gao.67As quantum dots have been studied by single dot photoluminescence spectroscopy at T= 1.5 K. Emission from the biexciton state is observed, for which we find a binding energy of 5 meV, also, larger multi-exciton complexes are observed at higher excitation intensities. These artificial atoms are found to have an intersublevel spacing of7O meV. In magnetic field, we observe Zeeman splitting ofthe exciton and biexciton spectral lines.
Supplementary Figure 11 from Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC (2023)

&lt;p&gt;Supplementary Figure 11 - PDF file 255K, Analysis of the role of AXL in mediating CO-1686 resistance in COR cell clones.&lt;/p&gt;
Whole cell pertussis vaccine expressing the Pneumococcal Surface protein A as an approach for a double vaccine (2018)

Background: Streptococcus pneumoniae (pneumococcus) is an important agent of respiratory infections that causes the death of around 400 thousand children per year, in the world. Pneumococcal Surface protein A (PspA) is a good candidate for the composition of protein vaccines, since it confers protection in animal models of infection, representing an alternative to conjugate vaccines. In previous studies, we have shown that the whole cell pertussis vaccine (wP produced at Instituto Butantan, Brazil, has adjuvant activity when combined to PspA, inducing high levels of antibodies and protection against pneumococcal infection in BALB/c mice. Methods & Materials: In this work we have constructed a Bordetella pertussis strain, derived from the vaccinal strain from Instituto Butantan. The pspA4 gene was cloned into a suicide vector in fusion with the N-terminal sequence of the B. pertussis filamentous haemagglutinin gene (fha44) and flanked by the upstream and downstream sequences of the dermonecrotic toxin gene. Results: Insertion of the fhA44:pspA construct in the genome of B. pertussis was confirmed by PCR and expression of the FHA44:PspA protein was confirmed by western-blot. Inactivated vaccines were prepared from two clones of BpPspA through the treatment with formaldehyde, producing wPPspA vaccines, following the protocol of wP production at Instituto Butantan. Mice were immunized with three subcutaneous doses and the induction of anti-PspA IgG was evaluated in the sera. Although low levels of anti-PspA IgG were observed in immunized mice, significant increased survival against a lethal pneumococcal challenge was observed. Modifications in the inactivation protocol as well as increase in vaccine doses are being performed, in order to improve the anti-PspA immune responses. Conclusion: Our results indicate that this is a promising strategy for the production of a double Pneumococcal and Pertussis vaccine.
Effects of the dissociation energy of added alkali metal salts and glass transition temperature on the ionic conduction for polymer hybrid films. (1986)

チオシアン酸アルカリ金属侮を分散させたポリメタクリル酸オリゴ(オキシエチレン)複合膜のイオン伝導度はK＞Na＞Liの順になることを観測した。イオン半径が大きいのにKSCN分散系で高いイオン伝導度(σ1=3.3×10-5S/cm, 25℃) を示す理由は, 塩の解離エネルギーが小さく, 同じ雰囲気での比較ではキャリヤーイオン生成に有利なためと考えられる。また, イオン伝導は伝導経路の粘性の影響も強く受けるため, 添加塩濃度増大にともない伝導度は極大値をとおって減少する。σ1の減少は複合膜のガラス転移温度の変化に影響され, Tgの上昇がσ1低下を引き起こすことが明らかとなった。
Bacterial endocarditis in a child presenting with acute arterial ischemic stroke: should thrombolytic therapy be absolutely contraindicated? (2009)

Thrombolysis is considered to be contraindicated in acute ischemic stroke secondary to infective endocarditis (IE). We report a 12-year-old female who presented with acute dense right hemiparesis and aphasia. Cranial magnetic resonance imaging and angiography showed multiple diffusion-restricted lesions in the left hemisphere and absence of flow in the left internal carotid artery. She was treated with intra-arterial tissue plasminogen activator within 6 hours of her presentation. Subsequently she was diagnosed with pneumococcal endocarditis and underwent debridement of vegetations and patch repair of the mitral valve. The patient did not have hemorrhagic complications following thrombolytic therapy or surgery. Pathological analysis of the mitral valve vegetations revealed mostly fibrin thrombus. Follow-up imaging showed complete recanalization of the left internal carotid artery, and the patient had a remarkable neurological recovery. This is the first case report of successful intra-arterial thrombolytic therapy in childhood IE-related stroke. We believe that thrombolytic therapy contributed to a favorable outcome in our patient and may be safe in selected patients with childhood IE-related acute ischemic stroke.