gebhart/patrepeval huggingface dataset:
Are There Wireless Hidden Cameras Spying on Me? (2022)

The proliferation of IoT devices has created risks of their abuse for unauthorized sensing/monitoring of our daily activities. Especially, the leakage of images taken by wireless spy cameras in sensitive spaces, such as hotel rooms, Airbnb rentals, public restrooms, and shower rooms, has become a serious privacy concern/threat. To mitigate/address this pressing concern, we propose a Spy Camera Finder (SCamF) that uses ubiquitous smartphones to detect and locate wireless spy cameras by analyzing encrypted Wi-Fi network traffic. Not only by characterizing the network traffic patterns of wireless cameras but also by reconstructing encoded video frame sizes from encrypted traffic, SCamF effectively determines the existence of wireless cameras on the Wi-Fi networks, and accurately verifies whether the thus-detected cameras are indeed recording users’ activities. SCamF also accurately locates spy cameras by analyzing reconstructed video frame sizes. We have implemented SCamF on Android smartphones and evaluated its performance on a real testbed across 20 types of wireless cameras. Our experimental results show SCamF to: (1) classify wireless cameras with an accuracy of 0.98; (2) detect spy cameras among the classified wireless cameras with a true positive rate (TPR) of 0.97; (3) incur low false positive rates (FPRs) of 0 and 0.031 for non-camera devices and cameras not recording the users’ activities, respectively; (4) locate spy cameras with centimeter-level distance errors.
Carbocationic Polymerization in the Presence of Sterically Hindered Bases. I. α-Methylstyrene Polymerization in the Presence of Sterically Hindered Bases (1982)

Abstract The effect of the sterically hindered base 2,6-di-tert-butyl-pyridine (DtBP) on the polymerization of α-methylstyrene (αMeSt initiated by “H2O”/BCl3 in a wide temperature range) has been investigated. αMeSt polymerizations carried out under identical conditions except in the presence of DtBP give much lower yield, much higher molecular weight, and noticeably narrower distributions than those obtained in the absence of this hindered base. The possibility of DtBP acting as an inhibitor is ruled out. Yields, molecular weights, and molecular weight distributions virtually do not change by changing DtBP concentration from 1.0 × 10−1 to 1.0 × 10−3 M. Differences in conversion levels do not explain the observed phenomena. PaMeSt samples obtained in the presence of trace amount of DtBP were of much higher molecular weight than those prepared in the absence of hindered pyridine, even at the same conversion level. These findings are explained by proposing that DtBP is a specific proton scavenger able to trap protons emerging during chain transfer to monomer, and that other elementary events remain unaffected by the presence of this hindered base.
LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model (2017)

No treatments exist to slow or halt Parkinson's disease (PD) progression; however, inhibition of leucine-rich repeat kinase 2 (LRRK2) activity represents one of the most promising therapeutic strategies. Genetic ablation and pharmacological LRRK2 inhibition have demonstrated promise in blocking α-synuclein (α-syn) pathology. However, LRRK2 kinase inhibitors may reduce LRRK2 activity in several tissues and induce systemic phenotypes in the kidney and lung that are undesirable. Here, we test whether antisense oligonucleotides (ASOs) provide an alternative therapeutic strategy, as they can be restricted to the CNS and provide a stable, long-lasting reduction of protein throughout the brain. Administration of LRRK2 ASOs to the brain reduces LRRK2 protein levels and fibril-induced α-syn inclusions. Mice exposed to α-syn fibrils treated with LRRK2 ASOs show more tyrosine hydroxylase (TH)-positive neurons compared to control mice. Furthermore, intracerebral injection of LRRK2 ASOs avoids unwanted phenotypes associated with loss of LRRK2 expression in the periphery. This study further demonstrates that a reduction of endogenous levels of normal LRRK2 reduces the formation of α-syn inclusions. Importantly, this study points toward LRRK2 ASOs as a potential therapeutic strategy for preventing PD-associated pathology and phenotypes without causing potential adverse side effects in peripheral tissues associated with LRRK2 inhibition.
Electrochemical Behavior of Polyphenol Oxidase Immobilized in Self-Assembled Structures Layer by Layer with Cationic Polyallylamine (2000)

We report here a novel bioelectrode based on self-assembled multilayers of polyphenol oxidase intercalated with cationic polyallylamine built up on a thiol-modified gold surface. We use an immobilization strategy previously described by Hodak J. et al. (Langmuir 1997, 13, 2708-2716) Quartz crystal microbalance with electroacustic impedance experiments were carried out to follow quantitatively the multilayer film formation. The response of the self-assembly polyphenol oxidase-polyallylamine electrodes toward different metabolically related catecholamines was studied, to evaluate enzyme kinetics. For the analyzed compounds, only dopamine and its metabolite Dopac gave catalytic currents at applied potential close to 0 V. These responses were proportional to the number of polyphenol oxidase-immobilized layers and were also controlled by the enzymatic reaction. The combination of microgravimetric and electrochemical techniques allowed us to determine the kinetic enzymatic constants, showing that the decomposition rate for the enzyme-substrate complex is slower than the enzymatic reoxidation step.
Zeolites as Catalysts for the Synthesis of Fine Chemicals (2010)

This chapter contains sections titled: Introduction Acid-Catalyzed Reactions Base-Catalyzed Reactions Summary and Outlook References
Inhibition of ATPIF1 Ameliorates Severe Mitochondrial Respiratory Chain Dysfunction in Mammalian Cells (2014)

Mitochondrial respiratory chain disorders are characterized by loss of electron transport chain (ETC) activity. Although the causes of many such diseases are known, there is a lack of effective therapies. To identify genes that confer resistance to severe ETC dysfunction when inactivated, we performed a genome-wide genetic screen in haploid human cells with the mitochondrial complex III inhibitor antimycin. This screen revealed that loss of ATPIF1 strongly protects against antimycin-induced ETC dysfunction and cell death by allowing for the maintenance of mitochondrial membrane potential. ATPIF1 loss protects against other forms of ETC dysfunction and is even essential for the viability of human ρ° cells lacking mitochondrial DNA, a system commonly used for studying ETC dysfunction. Importantly, inhibition of ATPIF1 ameliorates complex III blockade in primary hepatocytes, a cell type afflicted in severe mitochondrial disease. Altogether, these results suggest that inhibition of ATPIF1 can ameliorate severe ETC dysfunction in mitochondrial pathology.
Honeycomb GaN micro-light-emitting diodes (2006)

An optimized design for a micro-light-emitting diode array is presented. Based on a honeycomb hexagonal closed-packed structure, the packing density of individual elements can be increased to over 80% to minimize wastage of junction area. The extended sidewall area provides additional light extraction pathways. The honeycomb light-emitting diode (LED) emits twice as much light compared to a conventional broad area LED with equal junction area, and 50% more light than a microdisk array LED. The significant improvement in efficiency makes the additional processing step worthwhile.
Trends in Instrumented Spine Procedures in the United States from 1993–1999 to 2000–2006 (2009)

Neurosurgery: August 2009 - Volume 65 - Issue 2 - p 402 doi: 10.1227/01.neu.0000358674.51230.7d
Standardizing compression testing for measuring the stiffness of human bone (2018)

Compression testing is a widely used technique for measuring the stiffness of bone but there is a great deal of inter-study variation in experimental techniques across the literature. Based on best evidence from the literature, suggestions for bone compression testing are made in this review, although further studies are needed to establish standardized bone testing techniques in order to increase the comparability and reliability of bone stiffness studies.<b>Cite this article</b>: S. Zhao, M. Arnold, S. Ma, R. L. Abel, J. P. Cobb, U. Hansen, O. Boughton. Standardizing compression testing for measuring the stiffness of human bone. <i>Bone Joint Res</i> 2018;7:524-538. DOI: 10.1302/2046-3758.78.BJR-2018-0025.R1.
NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM (2013)

Small-cell lung cancer and other aggressive neuroendocrine cancers are often associated with early dissemination and frequent metastases. We demonstrate that neurogenic differentiation 1 (NeuroD1) is a regulatory hub securing cross talk among survival and migratory-inducing signaling pathways in neuroendocrine lung carcinomas. We find that NeuroD1 promotes tumor cell survival and metastasis in aggressive neuroendocrine lung tumors through regulation of the receptor tyrosine kinase tropomyosin-related kinase B (TrkB). Like TrkB, the prometastatic signaling molecule neural cell adhesion molecule (NCAM) is a downstream target of NeuroD1, whose impaired expression mirrors loss of NeuroD1. TrkB and NCAM may be therapeutic targets for aggressive neuroendocrine cancers that express NeuroD1.
Optimal fault-tolerant signal detection (1990)

G.G.L. Meyer and H.L. Weinert (see ibid., vol.ASSP-34, p.973-8, Aug. 1986) use the majority rule for fault-tolerant detection. The authors extend this and examine a redundant system with a general voting rule. They present an optimal design for each individual processor and the optimal selection of the k-out-of-M voting rule. They give an analytic solution to the optimal voting policy for the special case of low false alarm rate, with arbitrary failure probabilities and receiver operating characteristics (ROCs). Performance is improved significantly by using the optimal voting rule instead of the majority voting rule, especially in the tail regions of the ROC.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Phytochemical Study on Seeds of Paeonia clusii subsp. rhodia—Antioxidant and Anti-Tyrosinase Properties (2023)

In this study, the black fertile (BSs) and the red unfertile seeds (RSs) of the Greek endemic <i>Paeonia clusii</i> subsp. <i>rhodia</i> (Stearn) Tzanoud were studied for the first time. Nine phenolic derivatives, <i>trans</i>-resveratol, <i>trans</i>-resveratrol-4'-O-β-d-glucopyranoside, <i>trans</i>-<i>ε</i>-viniferin, <i>trans</i>-gnetin H, luteolin, luteolin 3'-O-β-d-glucoside, luteolin 3',4'-di-O-β-d-glucopyranoside, and benzoic acid, along with the monoterpene glycoside paeoniflorin, have been isolated and structurally elucidated. Furthermore, 33 metabolites have been identified from BSs through UHPLC-HRMS, including 6 monoterpene glycosides of the paeoniflorin type with the characteristic cage-like terpenic skeleton found only in plants of the genus <i>Paeonia</i>, 6 gallic acid derivatives, 10 oligostilbene compounds, and 11 flavonoid derivatives. From the RSs, through HS-SPME and GC-MS, 19 metabolites were identified, among which nopinone, myrtanal, and <i>cis</i>-myrtanol have been reported only in peonies' roots and flowers to date. The total phenolic content of both seed extracts (BS and RS) was extremely high (up to 289.97 mg GAE/g) and, moreover, they showed interesting antioxidative activity and anti-tyrosinase properties. The isolated compounds were also biologically evaluated. Especially in the case of <i>trans</i>-gnetin H, the expressed anti-tyrosinase activity was higher than that of kojic acid, which is a well-known whitening agent standard.
ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma (2022)

Cell proliferation requires the orchestrated actions of a myriad of proteins regulating DNA replication, DNA repair and damage tolerance, and cell cycle. Proliferating cell nuclear antigen (PCNA) is a master regulator which interacts with multiple proteins functioning in these processes, and this makes PCNA an attractive target in anticancer therapies. Here, we show that a cell-penetrating peptide containing the AlkB homolog 2 PCNA-interacting motif (APIM), ATX-101, has antitumor activity in a panel of human glioblastoma multiforme (GBM) cell lines and patient-derived glioma-initiating cells (GICs). Their sensitivity to ATX-101 was not related to cellular levels of PCNA, or p53, PTEN, or MGMT status. However, ATX-101 reduced Akt/mTOR and DNA-PKcs signaling, and a correlation between high Akt activation and sensitivity for ATX-101 was found. ATX-101 increased the levels of γH2AX, DNA fragmentation, and apoptosis when combined with radiotherapy (RT). In line with the in vitro results, ATX-101 strongly reduced tumor growth in two subcutaneous xenografts and two orthotopic GBM models, both as a single agent and in combination with RT. The ability of ATX-101 to sensitize cells to RT is promising for further development of this compound for use in GBM.
DIAMOND HEMISPHERICAL RESONATOR FABRICATION BY ISOTROPIC GLASS ETCH (2014)

We have fabricated polycrystalline diamond hemispheres by Hot-Filament CVD (HFCVD) in spherical cavities wet-etched into a novel high temperature glass substrate. These resonators are 1.4 mm in diameter and have a Q of up to 143,000 in the fundamental wineglass mode, for a ringdown time of 2.4 seconds. Asfabricated resonators have the two degenerate modes frequency matched to as close as 7 Hz, or 0.04% of the resonant frequency (~16 kHz). We have demonstrated laser trimming on a segmented lip resulting in mode matching to better than 0.3 Hz. These resonators show great promise for use as Hemispherical Resonant Gyroscopes (HRGs) on a chip.
Nanobiotechnology : bioinspired devices and materials of the future (2008)

Table of contents: Preface A. Introduction 1. Nanobiotechnology Overview by Oded Shoseyov and Ilan Levy B. Biotemplating 2. Experimental Strategies Towards the Use of the Porin MspA as a Nanotemplate and for Biosensors by Stefan H. Bossmann, Katharine Janik, Megh Raj Pokhrel, and Michael Niederweis 3. Bionanotechnology and Bonanoscience of Artificial Bioassemblies by Steven S. Smith and Katarzyna Lamparska-Kupsik 4. Genetically Engineered S-Layer Proteins and S-Layer-Specific Heteropolysaccharides as Components of a Versatile Molecular Construction Kit for Applications in Nanobiotechnology by Margit Sara, Eva-Maria Egelseer, Dietmar Pum, Bernhard Schuster, and Uwe B. Sleytr C. Bionanoelectronics and Nanocomputing 5. Photoinduced Electron Transport in DNA: Towards Electronic Devices Based on DNA Architecture by Hans-Achim Wagenknecht 6. Effective Models for Charge Transport in DNA Nanowires by Rafael Gutierrez and Gianaurelio Cuniberti 7. Optimizing Photoactive Proteins for Optoelectronic Environments by Using Directed Evolution by Jason R. Hillebrecht, Jeremy F. Koscielecki, Kevin J. Wise, Mark P. Krebs, Jeffrey A. Stuart, and Robert R. Birge 8. DNA-Based Nanoelectronics by Rosa Di Felice and Danny Porath 9. Electrical Manipulation of DNA on Metal Surfaces by Marc Tornow, Kenji Arinaga, and Ulrich Rant 10. Nanocomputing by Jennifer Sager, Joseph Farfel, and Darko Stefanovic 11. Biomolecular Automata by Natasa Jonoska D. Nanomedicine, Nanopharmaceuticals and Nanosensing 12. Nanomedicine by Kewal K. Jain 13. Nano-Sized Carriers for Drug Delivery by Sanjeeb K. Sahoo, Tapan K. Jain, Maram K. Reddy, and Vinod Labhasetwar 14. Gene and Drug Delivery System with Soluble Inorganic Carriers by Jin-Ho Choy and Man Park 15. Molecules, Cells, Materials and Systems Design Based on Nano-Biotechnology for Use in Bioanalytical Technology byTetsuya Haruyama E. De-Novo Designed Structures 16. Self-Assembly of Short Peptides for Nanotechnological Applications by Ehud Gazit 17. Nanotube Membranes for Biotechnology by Lane A. Baker and Charles R. Martin 18. Engineering a Molecular Railroad by Russell J. Stewart and Loren Limberis 19. Water-based Nanotechnology: What if we could dope water? by Andreas Kage and Eran Gabbai
Injectable Hybrid Hydrogels, with Cell-Responsive Degradation, for Tumor Resection (2018)

Biocompatible soft materials have recently found applications in interventional endoscopy to facilitate resection of mucosal tumors. When neoplastic lesions are in organs that can be easily damaged by perforation, such as stomach, intestine, and esophagus, the formation of a submucosal fluid cushion (SFC) is needed to lift the tumor from the underlying muscle during the resection of neoplasias. Such procedure is called endoscopic submucosal dissection (ESD). We describe an injectable, biodegradable, hybrid hydrogel able to form a SFC and to facilitate ESD. The hydrogel, based on polyamidoamines, contains breakable silica nanocapsules covalently bound to its network and able to release biomolecules. To promote degradation, the hydrogel is composed of cleavable disulfide moieties that are reduced by the cells through secretion of glutathione. The same stimulus triggers the breaking of the silica nanocapsules; therefore, the entire hybrid material can be completely degraded and its decomposition depends entirely on the presence of cells. Interestingly, the hydrogel precursor solution showed rapid gelation when injected in vivo and afforded a long-lasting high mucosal elevation, keeping the cushion volume constant during the dissection. This novel material can provide a solution to ESD limitations and promote healing of tissues after surgery.
Low Temperature Raman Spectra of Dibenzyl; Comparison with Biphenyl and Paraterphenyl (1983)

Abstract The Raman spectra of crystal dibenzyl have been recorded from 293 down to 10 K. No typical temperature dependence which usually accompanies phase transitions has been observed in frequencies, intensities or background. A comparison is made with biphenyl and paraterphenyl whose evolution of Raman spectra with the temperature looks similar. The very broad bands observed at room temperature result from the superposition of the different modes which appear well separated at 10 K. This behavior is consistent with the large atomic thermal motion observed by X-ray analysis. Vibrational frequencies have been calculated using the intermolecular potential of the atom-atom type in the rigid phenyl approximation and compared with experimental data.
Dynamic Modeling and Simulation of Impact in (2004)

The objective of this paper is to study the dynamic modeling and simulation of a tether- net/gripper system during an impact, while it is being deployed or retrieved by a winch on a satellite orbiting around earth. We stick to Tether-Net system but the analysis is applicable to Tether-Gripper systems too. We assume that the net is deployed from the satellite in orbit and the motion is restricted to the orbital plane. This net captures a second satellite and tows it. The motion of a tether-net system can be broken down into the following phases: (i) Phase 1: Net is shot out from the satellite with the tether completely slack, (ii) Phase 2: Net comes to a location where the tether is taut while the drum on the orbiter is locked, (iii) Phase 3: Drum is unlocked and the net moves with the tether, (iv) Phase 4: Net captures a body. The continua (tether) is modeled using mode functions and coordinates. The theory of impulse and momentum can be used to model Phases 1, 2, and 4 of motion of the tether-net system. The dynamics of the motion of the system in phase 3 is characterized by differential and algebraic equations (DAEs). Matlab ODE solvers were used to solve these DAEs.
Disentangling Hippocampal Shape Anomalies in Epilepsy (2013)

Drug-resistant temporal lobe epilepsy (TLE) and epileptic syndromes related to malformations of cortical development (MCD) are associated with complex hippocampal morphology. The contribution of volume and position to the overall hippocampal shape in these conditions has not been studied. We propose a surface-based framework to localize volume changes through measurement of Jacobian determinants, and quantify fine-scale position and curvature through a medial axis model. We applied our methodology to T1-weighted 3D volumetric MRI of 88 patients with TLE and 78 patients with MCD, including focal cortical dysplasia (FCD, n = 29), heterotopia (HET, n = 40), and polymicrogyria (PMG, n = 19). Patients were compared to 46 age- and sex-matched healthy controls. Surface-based analysis of volume in TLE revealed severe ipsilateral atrophy mainly along the rostro-caudal extent of the hippocampal CA1 subfield. In MCD, patterns of volume changes included bilateral CA1 atrophy in HET and FCD, and left dentate hypertrophy in all three groups. The analysis of curvature revealed medial bending of the posterior hippocampus in TLE, whereas in MCD there was a supero-medial shift of the hippocampal body. Albeit hippocampal shape anomalies in TLE and MCD result from a combination of volume and positional changes, their nature and distribution suggest different pathogenic mechanisms.
Supplementary Figure 1 Legend from Effects of Dasatinib on Src Kinase Activity and Downstream Intracellular Signaling in Primitive Chronic Myelogenous Leukemia Hematopoietic Cells (2023)

Supplementary Figure 1 Legend from Effects of Dasatinib on Src Kinase Activity and Downstream Intracellular Signaling in Primitive Chronic Myelogenous Leukemia Hematopoietic Cells
Compensation in boron‐doped CVD diamond (2008)

Abstract Hall‐effect measurements on single crystal boron‐doped CVD diamond in the temperature interval 80–450 K are presented together with SIMS measurements of the dopant concentration. Capacitance–voltage measurements on rectifying Schottky junctions manufactured on the boron‐doped structures are also presented in this context. Evaluation of the compensating donor ( N D ) and acceptor concentrations ( N A ) show that in certain samples very low compensation ratios ( N D / N A below 10 –4 ) have been achieved. The influence of compensating donors on majority carrier transport and the significance for diamond device performance are briefly discussed. (© 2008 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Solid-Phase Acylating Reagents in New Format:  Macroporous Polymer Disks (2001)

Acylation resins in a new monolithic format have been prepared by the functionalization of polyethylene-encased porous poly(chloromethylstyrene-co-divinylbenzene) disks. These disks have been obtained from a monolithic rod prepared by polymerization in a cylindrical glass mold, then cut into a disk format. A free radical azo initiator 4,4'-azobis(4-cyanovaleric acid) attached to available chloromethyl functionalities at the surface of the pores was used to initiate graft polymerization of 4-acetoxystyrene or chloromethylstyrene from the surface. Addition of a small percentage of divinylbenzene to the polymerization mixture leads to the formation of a layer of swellable reactive polymer gel at the surface of the macropores. This both prevents the undesirable increase in flow resistance through the monolith and improves the yield of grafting. The final reaction steps involve formation of an active phenolic moiety grafted to the disks and its reaction with acid anhydride. The use of grafted disks as acylating resin to transform various amines to amides in flow-through operations is demonstrated in a variety of solvents including alcohols. The acylation ability of the depleted disks can easily be recovered, and the disks can be reused many times.
[Effect of Rapamycin on CD4(+) CD25(+) regulatory T cells in allo-transplantation tolerance model]. (2007)

Rapa can increase the ratio of CD4(+) CD25(+) regulatory T cells in vitro and prolong the graft survival time obviously after adoptive immunity, and these effects are enhanced by low-dose of IL-2.