gebhart/patrepeval huggingface dataset:
1307: Renal Radiosurgery and Sorafenib as Non-Invasive Nephron-Sparing Treatment of Small Localized Renal Masses (2007)

You have accessJournal of UrologyModerated Poster 39, Tuesday, May 22, 2007, 10:00 am - 12:00 pm1 Apr 20071307: Renal Radiosurgery and Sorafenib as Non-Invasive Nephron-Sparing Treatment of Small Localized Renal Masses Ram Ganapathi, Troy R. Gianduzzo, Arul Mahadevan, Monish Aron, Lee E. Ponsky, and Inderbir S. Gill Ram GanapathiRam Ganapathi More articles by this author , Troy R. GianduzzoTroy R. Gianduzzo More articles by this author , Arul MahadevanArul Mahadevan More articles by this author , Monish AronMonish Aron More articles by this author , Lee E. PonskyLee E. Ponsky More articles by this author , and Inderbir S. GillInderbir S. Gill More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)31521-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1307: Renal Radiosurgery and Sorafenib as Non-Invasive Nephron-Sparing Treatment of Small Localized Renal Masses." The Journal of Urology, 177(4S), p. 430 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 430 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Ram Ganapathi More articles by this author Troy R. Gianduzzo More articles by this author Arul Mahadevan More articles by this author Monish Aron More articles by this author Lee E. Ponsky More articles by this author Inderbir S. Gill More articles by this author Expand All Advertisement PDF DownloadLoading ...
HIV-1 transcription is regulated by splicing factor SRSF1 (2014)

Efficient transcription of the HIV-1 genome is regulated by Tat, which recruits P-TEFb from the 7SK small nuclear ribonucleoprotein (snRNP) and other nucleoplasmic complexes to phosphorylate RNA polymerase II and other factors associated with the transcription complex. Although Tat activity is dependent on its binding to the viral TAR sequence, little is known about the cellular factors that might also assemble onto this region of the viral transcript. Here, we report that the splicing factor SRSF1 (SF2/ASF) and Tat recognize overlapping sequences within TAR and the 7SK RNA. SRSF1 expression can inhibit Tat transactivation by directly competing for its binding to TAR. Additionally, we provide evidence that SRSF1 can increase the basal level of viral transcription in the absence of Tat. We propose that SRSF1 activates transcription in the early stages of viral infection by recruiting P-TEFb to TAR from the 7SK snRNP. Whereas in the later stages, Tat substitutes for SRSF1 by promoting release of the stalled polymerase and more efficient transcriptional elongation.
Modulation transfer function testing of detector arrays using narrow-band laser speckle (1993)

method for measuring the modulation transferfunction (MTF) of a detector array from zero spatial frequency to twice the Nyquist frequency is presented. Laser speckle with a tunable, narrow spatial-frequency bandpass is used. The MTF measured with this method is compared to the MTF measured using sine targets. The results of the two methods agree to within 2%.
Histidine Hydrogen-Deuterium Exchange Mass Spectrometry for Probing the Microenvironment of Histidine Residues in Dihydrofolate Reductase (2011)

Our results demonstrate the usefulness of His-HDX-MS in probing the microenvironments of histidine residues within proteins.
Biological modeling in thermoradiotherapy: present status and ongoing developments toward routine clinical use (2022)

Biological modeling for anti-cancer treatments using mathematical models can be very supportive in gaining more insight into dynamic processes responsible for cellular response to treatment, and predicting, evaluating and optimizing therapeutic effects of treatment. This review presents an overview of the current status of biological modeling for hyperthermia in combination with radiotherapy (thermoradiotherapy). Various distinct models have been proposed in the literature, with varying complexity; initially aiming to model the effect of hyperthermia alone, and later on to predict the effect of the combined thermoradiotherapy treatment. Most commonly used models are based on an extension of the linear-quadratic (LQ)-model enabling an easy translation to radiotherapy where the LQ model is widely used. Basic predictions of cell survival have further progressed toward 3 D equivalent dose predictions, i.e., the radiation dose that would be needed without hyperthermia to achieve the same biological effect as the combined thermoradiotherapy treatment. This approach, with the use of temperature-dependent model parameters, allows theoretical evaluation of the effectiveness of different treatment strategies in individual patients, as well as in patient cohorts. This review discusses the significant progress that has been made in biological modeling for hyperthermia combined with radiotherapy. In the future, when adequate temperature-dependent LQ-parameters will be available for a large number of tumor sites and normal tissues, biological modeling can be expected to be of great clinical importance to further optimize combined treatments, optimize clinical protocols and guide further clinical studies.
Scheduling with flexible process plans (1993)

Abstract When a process planning module is embedded into the scheduling paradigm, the solution space of the scheduling problem is expanded due to possible generation and use of alternative process plans, i.e. the combined system of process planning and scheduling is equivalent to scheduling with flexible process plans. This flexibility provides a potential for obtaining improved schedules, but it increases the complexity of the structure of the scheduling problem. This paper describes a solution approach for the integrated system and analyses the performance of a new algorithm under various simulated scenarios.
Acoustic waves excited by phonon decay govern the fracture of brittle materials (2012)

The behavior of brittle materials under ballistic impacts is often associated with failure waves that are producing small fracture particles with a surface area requiring large energy input. Numerous attempts to explain this effect since the 1960s did not yield convincing results. Here we propose that failure waves can be interpreted as the result of the decay of the shock-excited phonon continuum into low frequency peaks in the phonon density of states. This results in a situation where pressure amplitude of the localized acoustic waves exceeds a critical fracture quantity such as the tensile strength of the material. Experimental confirmation of this model is presented by using fractured particle size analyses and comparing their results with predicted acoustic wavelengths.
UPREGULATION OF A20, AN ANTI-APOPTOTIC GENE, IS ASSOCIATED WITH HUMAN RENAL ALLOGRAFT REJECTION. (2000)

Avihingsanon, Yingyos1; Wang, Candace1; Zheng, Xin Xiao1; Ferran, Christiane2; Strom, Terry B.1; Ma, Naili1 Author Information
All‐nitride monochromatic amber‐emitting phosphor‐converted light‐emitting diodes (2009)

Abstract Phosphor conversion of light‐emitting diode (LED) radiation has been used in many configurations and combinations to generate white light. The concept of down conversion of, e.g., blue LED emission, offers also the possibility to provide efficient generation of monochromatic, high‐color‐purity light, especially in wavelength ranges in which direct radiation from non‐converted LEDs is relatively inefficient, i.e., in the “yellow gap”. In the case described here, a blue‐emitting LED is ‘fully’ converted to amber emission with a peak wavelength of 595 nm and a color purity of &gt;96%, while demonstrating an external quantum efficiency exceeding that of direct AlGaInP LEDs of the same wavelength by a factor of almost two at room temperature, and the lumen output under equal drive conditions at 85 °C by more than a factor of four. An essential component in this high performance is, besides the choice of the right – nitride – phosphor, the use of this phosphor in a densely sintered ceramic form which has considerable optical advantages over powders. (© 2009 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Understanding sulfonated kraft lignin re-polymerization by ultrafast reactions in supercritical water (2022)

Re-polymerization reactions are a commonly reported issue on the way to the higher recovery of monomers from lignin. The reactivity of monomers obtained from lignin depolymerization and their contribution to the re-polymerization in supercritical water (SCW) was investigated. Sulfonated Kraft lignin (SKL) was used along with four monomers: vanillin, vanillic acid, vanillyl alcohol and acetovanillone. Indulin Kraft lignin was also employed as the reference to understand the re-polymerization of SKL in SCW. The formation of diarylmethane structures was detected in HSQC spectra of solid residue after the SCW process. Lignin released fragments with free phenolic β-O-4 structures, as well as the monomeric product vanillyl alcohol are involved with the formation of o-o´ and o-p ´ diarylmethane structures. Chemical structure of Kraft lignin and its polymeric product after the SCW process was remarkably similar, as shown by HSQC, indicating that re-polymerization reactions occur through cross-linking polymerization, mainly in their fractions of low molecular weight products.
Investigation of Magnetic Equivalent Circuit Modeling Approaches for an Asymmetric and Unbalanced Winding Permanent Magnet Motor (2019)

This paper presents magnetic equivalent circuit (MEC) modeling approaches for an unbalanced and asymmetric winding 39-slot 12-pole permanent magnet (PM) motor. Such unconventional slot-pole configuration has certain benefits over conventional integral slot PM motors such as low cogging and torque ripple, and low rotor manufacturing cost. This slot-pole combination leads difficulty in analytical modeling since the motor symmetry is different from conventional PM motors. Simpler MEC modeling approaches would be useful in designing such motors with unconventional combinations. Four different MEC modeling approaches are investigated in this paper for an experimentally verified 39-slot 12-pole motor. Benefits and drawbacks of each approach are presented. No-load and on-load results obtained from MEC modeling approaches are compared with the finite element analysis (FEA) and test data to illustrate the benefits of the modeling approaches.
Effect of Shoe Inserts on Kinematics, Center of Pressure, and Leg Joint Moments during Running (2003)

The results of this study showed that subject-specific reactions to the tested inserts were often not as expected. Additionally, reactions were not consistent between the subjects. This result suggests that the prescription of inserts and/or orthotics is a difficult task and that methods must be developed to test and assess these effects. Such methods, however, are not currently available.
Phenotypic analysis of hMSH2 mutations in mouse cells carrying human chromosomes (2001)

Conversion of diploidy to haploidy is a method that allows the generation of stable murine/human hybrid cell lines carrying selected human chromosomes in only a single copy. In this setting, it is possible to detect genetic mutations with greater sensitivity and reliability than in diploid cells. Using this method, we were able to identify mutations in the human mismatch repair (MMR) gene hMSH2 in hereditary nonpolyposis colon cancer families, which have escaped detection by the conventional methods. In this report, we show that such hybrid cell lines can also be a valuable tool in the study of the mutated MMR proteins, in particular the variants found in hereditary nonpolyposis colon cancer families that carry missense mutations and where it is unclear whether they predispose to colon cancer. This analysis is made possible by the fact that the human hMSH2 protein is able to complement the MMR defect in the host murine cell line.
Errors in Quantitative Image Analysis due to Platform-Dependent (2014)

PURPOSE: To evaluate the ability of various software (SW) tools used for quantitative image analysis to properly account for source-specific image scaling employed by magnetic resonance imaging manufacturers. METHODS: A series of gadoteridol-doped distilled water solutions (0%, 0.5%, 1%, and 2% volume concentrations) was prepared for manual substitution into one (of three) phantom compartments to create “variable signal,” whereas the other two compartments (containing mineral oil and 0.25% gadoteriol) were held unchanged. Pseudodynamic images were acquired over multiple series using four scanners such that the histogram of pixel intensities varied enough to provoke variable image scaling from series to series. Additional diffusion-weighted images were acquired of an ice-water phantom to generate scanner-specific apparent diffusion coefficient (ADC) maps. The resulting pseudodynamic images and ADC maps were analyzed by eight centers of the Quantitative Imaging Network using 16 different SW tools to measure compartment-specific region-of-interest intensity. RESULTS: Images generated by one of the scanners appeared to have additional intensity scaling that was not accounted for by the majority of tested quantitative image analysis SW tools. Incorrect image scaling leads to intensity measurement bias near 100%, compared to nonscaled images. CONCLUSION: Corrective actions for image scaling are suggested for manufacturers and quantitative imaging community.
A dopamine D3 receptor partial agonist blocks the expression of conditioned activity (2002)

The partial dopamine D3 receptor agonist BP 897 attenuates cocaine seeking suggesting that BP 897 will attenuate conditioned activity to environmental stimuli paired with amphetamine. During conditioning, amphetamine (2.0 mg/kg) stimulated activity and co-treatment with BP 897 (1.0 mg/kg) had no effect. In the saline test, groups conditioned with amphetamine or amphetamine plus BP 897 showed conditioned activity. Treatment with BP 897 in the test following conditioning with saline produced no significant effect but following conditioning with amphetamine BP 897 blocked conditioned activity. Results extend previous findings that BP 897 attenuates responding for cocaine-paired stimuli to amphetamine-paired stimuli in a different paradigm and support the potential of BP 897 as a therapeutic agent for the prevention of drug seeking.
Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study (2018)

Recent in vitro cardiac safety studies demonstrate the ability of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to detect electrophysiologic effects of drugs. However, variability contributed by unique approaches, procedures, cell lines, and reagents across laboratories makes comparisons of results difficult, leading to uncertainty about the role of hiPSC-CMs in defining proarrhythmic risk in drug discovery and regulatory submissions. A blinded pilot study was conducted to evaluate the electrophysiologic effects of 8 well-characterized drugs on 4 cardiomyocyte lines using a standardized protocol across 3 microelectrode array platforms (18 individual studies). Drugs were selected to define assay sensitivity of prominent repolarizing currents (E-4031 for IKr, JNJ303 for IKs) and depolarizing currents (nifedipine for ICaL, mexiletine for INa) as well as drugs affecting multichannel block (flecainide, moxifloxacin, quinidine, and ranolazine). Inclusion criteria for final analysis was based on demonstrated sensitivity to IKr block (20% prolongation with E-4031) and L-type calcium current block (20% shortening with nifedipine). Despite differences in baseline characteristics across cardiomyocyte lines, multiple sites, and instrument platforms, 10 of 18 studies demonstrated adequate sensitivity to IKr block with E-4031 and ICaL block with nifedipine for inclusion in the final analysis. Concentration-dependent effects on repolarization were observed with this qualified data set consistent with known ionic mechanisms of single and multichannel blocking drugs. hiPSC-CMs can detect repolarization effects elicited by single and multichannel blocking drugs after defining pharmacologic sensitivity to IKr and ICaL block, supporting further validation efforts using hiPSC-CMs for cardiac safety studies.
ChemInform Abstract: An Improved Procedure for the Synthesis of N‐Substituted 3,4‐ Dichloromaleinimides. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
RCM of Tripeptide Dienes Containing a Chiral Vinylcyclopropane Moiety:  Impact of Different Ru-Based Catalysts on the Stereochemical Integrity of the Macrocyclic Products (2005)

[structures: see text] Tripeptide dienes containing an (1R,2S)-vinyl aminocyclopropylcarboxylate residue were cyclized to beta-strand scaffolds under ring-closing metathesis (RCM). Conformational factors, ligand effects, and reaction conditions were evaluated. A protocol was developed for the efficient synthesis of 15-membered ring peptides in high diastereomeric purity. These peptides are key synthetic precursors to antiviral agents that target the hepatitis C virus and represent the first class of clinically validated pharmaceutical agents that are synthesized in large scale using RCM.
Online Nanoparticle Mass Measurement by Combined Aerosol Particle Mass Analyzer and Differential Mobility Analyzer: Comparison of Theory and Measurements (2009)

A combination of a differential mobility analyzer (DMA) and aerosol particle mass analyzer (APM) is used to measure the mass of NIST Standard Reference Materials (SRM®) PSL spheres with 60 and 100 nm nominal diameter, and NIST traceable 300 nm PSL spheres. The calibration PSL spheres were previously characterized by modal diameter and spread in particle size. We used the DMA to separate the particles with modal diameter in a narrow mobility diameter range. The mass of the separated particles is measured using the APM. The measured mass is converted to diameter using a specific density of 1.05. We found that there was good agreement between our measurements and calibration modal diameter. The measured average modal diameters are 59.23 and 101.2 nm for nominal diameters of 60 and 100 nm (calibration modal diameter: 60.39 and 100.7 nm) PSL spheres, respectively. The repeatability uncertainty of these measurements is reported. For 300 nm, the measured diameter was 305.5 nm, which is an agreement with calibration diameter within 1.8%.The effect of spread in particle size on the APM transfer function is investigated. Two sources of the spread in “mono-dispersed” particle size distributions are discussed: (a) spread due to the triangular DMA transfer function, and (b) spread in the calibration particle size. The APM response function is calculated numerically with parabolic flow through the APM and diffusion broadening. As expected from theory, the calculated APM response function and measured data followed a similar trend with respect to APM voltage. However, the theoretical APM transfer function is narrower than the measured APM response.
Extremely Coherent Microwave Emission from Spin Torque Oscillator Stabilized by Phase Locked Loop (2015)

Spin torque oscillator (STO) has been attracting a great deal of attention as a candidate for the next generation microwave signal sources for various modern electronics systems since its advent. However, the phase noise of STOs under free running oscillation is still too large to be used in practical microwave applications, thus an industrially viable means to stabilize its oscillation has been strongly sought. Here we demonstrate implementation of a phase locked loop using a STO as a voltage controlled oscillator (VCO) that generates a 7.344 GHz microwave signal stabilized by a 153 MHz reference signal. Spectrum measurement showed successful phase locking of the microwave signal to the reference signal, characterized by an extremely narrow oscillation peak with a linewidth of less than the measurement limit of 1 Hz. This demonstration should be a major breakthrough toward various practical applications of STOs.
MicroRNAs 17-5p/20a/106a Function as a Master Gene Complex Controlling Monocytopoiesis through AML1 Targeting. (2006)

Abstract MicroRNAs (miRs) are a novel regulatory class of non-coding, single-stranded RNAs of ~ 22 nucleotides, identified in plants and animals. MiRs repress protein expression at post-transcriptional level, mostly through base pairing to the 3′ untranslated region (UTR) of the target mRNA, thus leading to its degradation and/or reduced translation. MiRs have been shown to control basic biological functions, such as cell proliferation and differentiation. However, little is known on their role in hematopoiesis. Furthermore, in diverse types of cancer miRs may function as “oncomirs”. We investigated the role of miR-17-5p, -20a and -106a, located in the miR-17-5p-92 and miR-106a-92 clusters respectively, in monocytic-macrophage (Mo) differentiation-maturation. In unilineage Mo culture generated by cord blood (CB) hematopoietic progenitor cells (HPC), these miRs are gradually and markedly downmodulated, whereas AML1 is upmodulated at protein but not at mRNA level. The acute myeloid leukaemia-1 protein (AML1, also known as Runt-related transcription factor 1, Runx1) is the DNA-binding subunit of the hematopoietic transcription factor CBF, which plays a pivotal role in Mo differentiation-maturation. Luciferase assay shows that miR-17/20/106 bind the AML1 mRNA 3′UTR, implying that during monocytopoiesis their decline unblocks AML1 translation. Mo culture transfection with miR-17/20/106 stimulates blast cell proliferation and inhibits differentiation-maturation: this is coupled with AML1 translation blockade, leading in turn to inhibition of M-CSF receptor (M-CSFR) expression. Equivalent results were observed in Mo clonogenic culture of HPCs. Knockdown of endogenous miR-17/20/106 by anti-miR oligonucleotide transfection causes opposite effects. Altoghether, our studies indicate that miR-17/20/106 downmodulation during monocytopoiesis “unblocks” the translation of AML1, which in turn transactivates the M-CSFR, thereby allowing Mo differentiation and maturation. We hence propose that these miRs function as a master gene complex underlying the monocytopoiesis gene program, at least in part through the regulation of two pivotal proteins, AML1 and M-CSFR. This study also sheds light on other relevant aspects:the regulatory action of miR-17/20/106 action on AML1 mRNA is restricted to the Mo lineage, implying a role for lineage-specific factor(s) to modulate the interaction of these miRs with their mRNA target;the subtle complexity of mechanisms controlling the transcription/processing of the miR-17-5p-92 cluster, implied by the differential expression patterns of the miRs comprised in the 17-5p-92 polycistron in Mo culture;the leukemogenesis mediated by AML1 fusion proteins.
Frequency domain filter using an accurate reconfigurable FFT/IFFT core (2004)

As the time response for a given filter increases, frequency-domain implementation becomes attractive from a hardware resources point of view. This paper shows that for practical cases, the crossover between frequency-domain and time-domain implementations may be as low as 8 complex coefficients. The focus is on the design of efficient and reconfigurable FPGA implementations of frequency-domain filters. The filter size, binary word length of input, output, and coefficients are all configurable. Internal bus word lengths are also parameterized to control result accuracy. For example, a SQNR of 55 dB can be obtained for a 32 coefficient raised cosine filter of /spl alpha/=0.22 with 5 bit input and 12 bit output. This is compared to a maximum of 48 dB for a comparable FIR.