gebhart/patrepeval huggingface dataset:
Epigenetic Age Reversal by Cell-Extrinsic and Cell-Intrinsic Means (2019)

Reversal of aging by factors or drugs that reprogram adult cells to induced pluripotent stem cells suggests that at least at the cellular level aging may be reversible by resetting somatic cell state to a "ground state." An open question has been whether such rejuvenation is possible in whole organisms, especially in mammals. A related key question is whether rejuvenation can be dissociated from dedifferentiation. Several recent reports suggest that one prominent biomarker of mammalian aging, age-associated DNA methylation (DNAm) state that has been used to create DNAm age (DNAma) clocks, can be partially reversed by intrinsic treatment of cells with sets of reprogramming factors without affecting cell fate. Partial reprogramming using a superset of reprogramming factors applied transiently or subset of Yamanaka factors applied continually can increase regenerative potential, and reverse DNAma, while maintaining cell identity. Alternatively, a cell-extrinsic manipulation can accomplish something similar. A small preliminary clinical trial in humans suggests that systemic treatment with a cocktail of growth hormone, dehydroepiandrosterone, and metformin could also partially reverse DNAma and at the same time regenerate the thymus, which shrinks with age. Important questions are raised: How completely does reversing DNAma clocks embody a reversal of other age-related phenotypes, such as functional decline in strength, cognition, or immunity? How universal are these epigenetic changes at the tissue and cell levels? For example, do populations of younger stem cells exist that respond to these manipulations and then only confer the appearance of decreasing DNAma as they proliferate and differentiate? Together, these studies have profound implications for the development of antiaging and healthspan-enhancing therapies. A combination of both intrinsic and extrinsic modalities will most likely provide an optimal benefit.
Melanin concentrating hormone receptor 1 (MCHR1) antagonists—Still a viable approach for obesity treatment? (2012)

Obesity is a global epidemic associated with multiple severe diseases. Several pharmacotherapies have been investigated including the melanin concentrating hormone (MCH) and its receptor 1. The development of MCHR1 antagonists are described with a specific perspective on different chemotypes investigated in efforts to overcome hERG liabilities while having orally active, potent and selective compounds with sufficient brain penetration. A chemometric comparison of ∼2000 diverse MCHR1 and ∼1000 diverse hERG ligands underline the structural similarities. A binding pocket analysis of a MCHR1 model and recent X-ray structures of GPCRs invoked in selectivity issues indicate a way to support future drug design.
Proteomic differences between focal and diffuse traumatic brain injury in human brain tissue (2018)

The early molecular response to severe traumatic brain injury (TBI) was evaluated using biopsies of structurally normal-appearing cortex, obtained at location for intracranial pressure (ICP) monitoring, from 16 severe TBI patients. Mass spectrometry (MS; label free and stable isotope dimethyl labeling) quantitation proteomics showed a strikingly different molecular pattern in TBI in comparison to cortical biopsies from 11 idiopathic normal pressure hydrocephalus patients. Diffuse TBI showed increased expression of peptides related to neurodegeneration (Tau and Fascin, p < 0.05), reduced expression related to antioxidant defense (Glutathione S-transferase Mu 3, Peroxiredoxin-6, Thioredoxin-dependent peroxide reductase; p < 0.05) and increased expression of potential biomarkers (e.g. Neurogranin, Fatty acid-binding protein, heart p < 0.05) compared to focal TBI. Proteomics of human brain biopsies displayed considerable molecular heterogeneity among the different TBI subtypes with consequences for the pathophysiology and development of targeted treatments for TBI.
ChemInform Abstract: Novel Antibiotics, Amythiamicins. Part 2. Structure Elucidation of Amythiamicin D. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Evidence for X(3872) in PbPb collisions and studies of its prompt production at $\sqrt{s_\mathrm{NN}} =$ 5.02 TeV (2021)

The first evidence for X(3872) production in relativistic heavy ion collisions is reported. The X(3872) production is studied in lead-lead (PbPb) collisions at a center-of-mass energy of $\sqrt{s_\mathrm{NN}} =$ 5.02 TeV per nucleon pair, using the decay chain X(3872) $\to$ J$/ψ\, π^+π^- \to$ $μ^+μ^-π^+π^-$. The data were recorded with the CMS detector in 2018 and correspond to an integrated luminosity of 1.7 nb$^{-1}$. The measurement is performed in the rapidity and transverse momentum ranges $|y|$ $\lt$ 1.6 and 15 $\lt$ $p_\mathrm{T}$ $\lt$ 50 GeV$/c$. The significance of the inclusive X(3872) signal is 4.2 standard deviations. The prompt X(3872) to $ψ$(2S) yield ratio is found to be $ρ^\mathrm{PbPb} = $ 1.08 $\pm$ 0.49 (stat) $\pm$ 0.52 (syst), to be compared with typical values of 0.1 for pp collisions. This result provides a unique experimental input to theoretical models of the X(3872) production mechanism, and of the nature of this exotic state.
Fully integrated active magnetic probe for high-definition near-field measurement (2006)

In order to diagnose the topical EMI problem in ICs, a fully integrated active magnetic probe has been developed in SOI-CMOS technology. A 2-turn differential coil, differential amplifiers, a differential to single-ended converter, a output buffer and bias circuits are all integrated in a single-chip. Meas- urement result shows that it gains the high e-field suppression ratio of 38.0dB at 50MHz. Furthermore, the first 2D magnetic distribution map has been drawn by the active probe. The ob- tained image is finer than that of a shielded loop coil and it can prove an active probe to be a pragmatic diagnosis tool.
The suppressive effect of antibodies on cellular cooperation. (1976)

1) The primary and secondary anti-carrier antibody responses were markedly suppressed by the passively administered anti-carrier antibody but not by the anti-hapten antibody. 2) The primary and secondary anti-hapten antibody responses were suppressed not only by the passively administered anti-hapten antibody but also by the anti-carrier antibody. 3) Passively administered 3.5S fragments of the anti-carrier antibody selectively suppressed the anti-carrier antibody response but had no effect on the capacity of carrier-specific helper T cells to facilitate the anti-hapten antibody response. 4) Passively administered anti-carrier antibodies did not suppress the development of carrier-specific helper T cells but suppressed B memory cells specific for the haptenic group as well as the carrier determinant.
Towards solar cell emitters based on colloidal Si nanocrystals (2014)

The application of layers of doped colloidal silicon nanocrystals sandwiched between hydrogenated amorphous silicon layers as emitters in silicon heterojunction solar cells is explored. It is shown that such emitters provide excellent interface passivation and reasonable conductivity. Final solar cells with such nanoparticle emitters reach conversion efficiencies on the same level as solar cells with conventional hetero emitters. Quantum efficiency measurements indicate that the light absorbed in the nanocrystals contributes to the current extracted from the solar cell. The remaining challenges that need to be addressed before the application of such colloidal silicon nanocrystals for the processing of low-cost and potentially printable emitter layers becomes feasible are discussed.
International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature (2018)

Somatostatin, also known as somatotropin-release inhibitory factor, is a cyclopeptide that exerts potent inhibitory actions on hormone secretion and neuronal excitability. Its physiologic functions are mediated by five G protein-coupled receptors (GPCRs) called somatostatin receptor (SST)1-5. These five receptors share common structural features and signaling mechanisms but differ in their cellular and subcellular localization and mode of regulation. SST<sub>2</sub> and SST<sub>5</sub> receptors have evolved as primary targets for pharmacological treatment of pituitary adenomas and neuroendocrine tumors. In addition, SST<sub>2</sub> is a prototypical GPCR for the development of peptide-based radiopharmaceuticals for diagnostic and therapeutic interventions. This review article summarizes findings published in the last 25 years on the physiology, pharmacology, and clinical applications related to SSTs. We also discuss potential future developments and propose a new nomenclature.
Prediction of Laminations in Zinc Alloy Die-Casting by Gas-Liquid Two-Phase Flow Simulation (2021)

In the manufacturing process of zinc alloy die-casting, laminations are a serious problem because they cause blister defects and the deposition of zinc on the mold surface. Thus, it is very important to analytically predict the risk of lamination formation before determining the mold design. In this study, we proposed a criterion for predicting the locations of laminations. The criterion value is estimated from the result of a molten metal flow simulation and can indirectly predict the locations of laminations. As the analytic method in the mold-filling simulation, we adopted a gas-liquid two-phase flow model with a finite element method, and the Cahn-Hilliard equation was adopted to determine the interface between the gas and the liquid. We predicted the locations of laminations for two different types of gating system using the mold-filling simulation. The validity of the proposed criterion for laminations was confirmed by comparison of the results of the simulation and the observation of laminations after practical die-casting.
[Cancer of the prostate: influence of nutritional factors. General nutritional factors]. (2001)

Studies attempting to establish an epidemiological link between body mass index and the risk of cancer of the prostate have been contradictory. ENERGY INTAKE: No straightforward relationship between energy intake and cancer of the prostate has been identified. FAR INTAKE: According to epidemiology studies, there is a correlation between high-fat diet and the incidence of cancer of the prostate. It has thus been demonstrated that men whose diet contains more than 30 to 40% fat have a higher risk of developing cancer of the prostate than those whose diet contains less than 30% fat. In addition, high-fat diets favor progression of tumors in elderly subjects. ROLE OF SATURATED FAT: Saturated fat has been implicated most often in the development of cancer of the prostate, high intake being correlated with shorter survival after diagnosis of cancer.
An Information Foraging Theory Perspective on Tools for Debugging, Refactoring, and Reuse Tasks (2013)

Theories of human behavior are an important but largely untapped resource for software engineering research. They facilitate understanding of human developers’ needs and activities, and thus can serve as a valuable resource to researchers designing software engineering tools. Furthermore, theories abstract beyond specific methods and tools to fundamental principles that can be applied to new situations. Toward filling this gap, we investigate the applicability and utility of Information Foraging Theory (IFT) for understanding information-intensive software engineering tasks, drawing upon literature in three areas: debugging, refactoring, and reuse. In particular, we focus on software engineering tools that aim to support information-intensive activities, that is, activities in which developers spend time seeking information. Regarding applicability, we consider whether and how the mathematical equations within IFT can be used to explain why certain existing tools have proven empirically successful at helping software engineers. Regarding utility, we applied an IFT perspective to identify recurring design patterns in these successful tools, and consider what opportunities for future research are revealed by our IFT perspective.
Quality Management Alliance Eliminates Plug Failures (1994)

Abstract Plug cementing is a very broad term that may include setting cement plugs for abandonment, sidetracking a wellbore, lost-circulation control, or remedial work. There are several means by which this may be accom- plished, including the balanced plug and dump bailer methods. Unfortunately, plug cementing is a process that often receives simplistic treatment. However, even plug cementing is by no means simplistic and can be very costly if not properly executed. In addition to the immediate rig time and materials cost associated with a poor cement plug, there are also potential costs from well control and environmental problems. This paper describes the activities and results of an operator/service company quality alliance. The immedi- ate project goal was to improve the success rate of cement sidetrack plugs in the US Gulf Coast operating area. All aspects of the cementing process, including slurry design, material and job quality control, and displacement practices were systematically evaluated and modified as necessary. During the latter stages of the project, a recommended plug procedure (RPP) was established that addressed many of the shortcomings of past practices. A continuous job evaluation process or "Quality Management System" was also implemented to ensure continuous monitoring and refinement of the RPP. Before this procedure was implemented, the prevailing standard in the Gulf Coast was approximately two to five attempts to achieve a successful sidetrack plug. The industry average was approximately 2.4 attempts per kickoff. As of this writing, proper use of the RPP outlined by the study group has achieved a near 100% success rate. Although originally targeted for the Gulf Coast operating area, the RPP has proven to be a global success. This program has provided a multi-million dollar cost reduction to the operating companies using it, and illustrates the value of properly structured operator/service company technology alliances.
Strain Hardening of Red Blood Cells by Accumulated Cyclic Supraphysiological Stress (2006)

The effect of elevated shear stress upon cellular trauma has been studied for many years, but the effect of long-term cyclic stress trauma on hemorheology has never been explored systematically. This study investigated sublytic trauma of red blood cells (RBCs) caused by repeated exposure to shear stress. A suspension of bovine blood was throttled through a capillary tube (inner diameter 1 mm and length 70 mm) connected to a recirculating flow loop. Samples were withdrawn every 30 min to measure deformability and characteristic time. The deformability of the cell was measured microscopically by observing the shape of the cell during the shear flow. It was found that cyclic shear irreversibly stiffened the cell membrane while the effect was not so much as that of continuous shear. The cell deformability was dramatically reduced by 73% when the stress of 300 Pa was applied for 288 s, while it was 7% under 90 Pa. These results elucidate the need for improved models to predict cellular trauma within the unsteady flow environment of mechanical circulatory assist devices.
Fabrication of Plane Optical Mosaics Imitating Human Corneal Endothelium (2013)

International audience
Low temperature infrared spectral study of iron(II) dioxygen complexes derived from a picket fence porphyrin (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLow temperature infrared spectral study of iron(II) dioxygen complexes derived from a picket fence porphyrinJames P. Collman, Robert R. Gagne, Harry B. Gray, and Jeffrey W. HareCite this: J. Am. Chem. Soc. 1974, 96, 20, 6522–6524Publication Date (Print):October 1, 1974Publication History Published online1 May 2002Published inissue 1 October 1974https://pubs.acs.org/doi/10.1021/ja00827a050https://doi.org/10.1021/ja00827a050research-articleACS PublicationsRequest reuse permissionsArticle Views168Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Retardation and promotion of growth of spontaneously appearing tumors using immune lymphocytes previously exposed to embryonic antigens. (1982)

Spleen lymphocytes taken from mice at various stages of pregnancy or growth of s.c. syngeneic tumor implants have been examined for their ability to cause cytolysis of embryo fibroblasts in culture or to affect the growth of the transplanted tumor cells in vivo. Activity of different lymphoid populations in affecting tumor growth in vivo was correlated with activity in vitro, whether cytolysis (growth inhibition) or blocking of cytolysis (growth promotion) was considered. The evidence favors an important role for lymphoid responses to embryo-associated antigens in the control of spontaneous tumor growth, although one cannot yet rule out a crucial role for the host milieu rather than, or in addition to, host cellular elements being the important feature of this control process.
ansa‐Metallocene and Half‐Sandwich Complexes of Group‐3 Metals and Lanthanides Incorporating Fluorenyl‐Based Ligands: From Synthesis to Catalytic Applications (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
ChemInform Abstract: Photoactivated Oxidation of Alcohols by Oxygen. (1986)

Abstract Photochemisch werden Alkohole in Gegenwart von HzPtClö/CuClz bei Bestrahlung mit 488 nm durch O 2 zu entsprechenden Aldehyden bzw. Ketonen mit Ausb. bis zu 98% oxidiert.
Experimental Approach for Complex Optical Fiber Angular Orientation and Twist Measurement (2021)

Applications associated with complex, structured optical fibers having no circular symmetry often require information about their specific angular orientation. Such cases include, for example, splicing, sophisticated mode coupling, selective fiber Bragg gratings inscription, or direction‐sensitive sensing. Besides the external angular orientation of the fiber, additionally an intrinsic twist of the internal fiber structure has been identified as a critical parameter for applications. Such an intrinsic fiber twist might occur as a side effect of the fiber drawing process, or it may have been introduced intentionally as a special fiber property. In all such cases, a measurement of the local orientation along the fiber is highly desirable. A method for such measurements based on the analysis of the refractive–diffractive scattering patterns is presented. By comparing such measured patterns with reference patterns from modeling or from reference measurements, the orientation of the fiber can be identified with high accuracy and without measuring or reconstructing the detailed cross section of a fiber. The method, therefore, provides an approach for quick identification of a local angular fiber orientation status.
Radiation characteristics of Dipole Antenna with Bended Parasitic Element in the Vicinity of a Lossy medium (2007)

Built-in antennas of mobile terminals are used in the vicinity of lossy dielectric media such as a user’s hand, body or head. It is well known that an antenna performance will deteriorate dramatically due to the lossy media. In addition, there are various relative positions between antenna and lossy media depending on the situation such as when making a call, sending mail or in standby status. In such a situation, the valid radiation characteristic is a unidirectional radiation pattern in a direction opposite to a lossy medium [1]. Optimal performance is required of the builtin antennas in these situations. Tunable antennas capable of tuning their own electrical characteristics have been studied in order to optimize their performance in various situations [2]. However, there are many problems to be solved, for instance, insertion loss of an active device. In this work, we have assumed that a mobile terminal is put in a user’s breast pocket. The mobile terminal put in the pocket has two states of back side or front side. We have conducted a basic study of an antenna capable of improving radiation characteristics in the two states without using active devices. Our proposed antenna is a dipole antenna with a bended parasitic element. The parasitic element acts as director or reflector in the case that the relative positions of antenna and high-permittivity lossy dielectric media change. The simulated results in the case of a thin mobile terminal in proximity to lossy media for both the front and the back sides are shown.
Structural features of iron‐phosphate glass (2017)

Abstract This paper reports a study and discusses the role of Fe ions in the inhibition of corrosion of iron phosphate glasses. The structure of the 40Fe 2 O 3 –60P 2 O 5 (mol%) glass, having a confirmed dissolution rate in aqueous solution at 90°C superior to borosilicate glasses, was investigated. Samples were crystallized at characteristic temperatures defined by differential thermal analysis and analyzed by X‐ray diffraction. Crystalline phases of Fe 2 Fe[P 2 O 7 ] 2 and Fe 4 [P 2 O 7 ] 3 were detected. The hyperfine parameters from the Mössbauer spectrum indicate that both Fe 2+ and Fe 3+ ions are in octahedral coordination, and 18% of the Fe 3+ ions in the starting batch are reduced to Fe 2+ ions after melting. The broad and symmetric spectra centered in g≈2.0 from the EPR measurements indicate the presence of two or more Fe interacting ions occupying sites of relatively high local symmetry.
Characterization of CMR-derived haemodynamic data in children with pulmonary arterial hypertension (2016)

Wall shear stress, the principal haemodynamic force driving endothelial functional changes, is severely decreased in paediatric PAH patients and correlates with increased stiffness in the proximal pulmonary vasculature and reduced RV function.
ChemInform Abstract: In situ Laser Raman Spectroscopy Studies of the Transformation of VOHPO4×0.5H2O and (VO)2P2O7. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplemental Table 2 from mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8<sup><b>+</b></sup> T and NK Cells to Generate Antitumor Immunity (2023)

&lt;p&gt;Differential Gene Expression Analysis of Bulk RNA from MC38 Tumors After mWTX-330 Treatment&lt;/p&gt;