gebhart/patrepeval huggingface dataset:
Arabidopsis late blight: infection of a nonhost plant by Albugo laibachii enables full colonization by Phytophthora infestans. (2016)

The oomycete pathogen Phytophthora infestans causes potato late blight, and as a potato and tomato specialist pathogen, is seemingly poorly adapted to infect plants outside the Solanaceae. Here, we report the unexpected finding that P. infestans can infect Arabidopsis thaliana when another oomycete pathogen, Albugo laibachii, has colonized the host plant. The behaviour and speed of P. infestans infection in Arabidopsis pre-infected with A. laibachii resemble P. infestans infection of susceptible potato plants. Transcriptional profiling of P. infestans genes during infection revealed a significant overlap in the sets of secreted-protein genes that are induced in P. infestans upon colonization of potato and susceptible Arabidopsis, suggesting major similarities in P. infestans gene expression dynamics on the two plant species. Furthermore, we found haustoria of A. laibachii and P. infestans within the same Arabidopsis cells. This Arabidopsis-A. laibachii-P. infestans tripartite interaction opens up various possibilities to dissect the molecular mechanisms of P. infestans infection and the processes occurring in co-infected Arabidopsis cells.
<title>Fabrication of continuous-relief micro-optical elements by direct laser writing in photoresist</title> (1994)

Progress in the fabrication of continuous-relief micro-optical elements by direct laser writing in photoresist followed by replication into epoxy or polymer materials is described. The technology enables a wide range of micro-optical elements to be fabricated and replicated using Ni shims electroformed from the photoresist originals. Examples of fabricated micro- optical elements are described, including microlens arrays, Fresnel microlenses, kinoforms, and other continuous microrelief phase elements.
Acromégalie due à une sécrétion ectopique de GHRH par des tumeurs carcinoïdes bronchiques : Rapport de 2 cas (2010)

peer reviewed
Practices in Testing of Mixed-Signal and RF SoCs (2005)

The presentation includes an overview of challenges in testing analog, mixed signal, and RF SoCs, and presents alternative solutions to ATE functional testing for products that are suitable for high volume manufacturing. This talk presents a different level of granularity within mixed signal SoC testing by abstracting the systems in terms of product types, specifications, interfaces, or building blocks. This way, the final testing of the SoC becomes an aggregation of the test techniques targeted for particular product types, interfaces, and building blocks incorporated in the system. Several industrial examples of production testing of mixed-signal and RF devices are presented in this talk
Effect of Acute Exercise on Prostate Cancer Cell Growth (2013)

Physical activity is associated with reduced risk of several cancers, including aggressive prostate cancer. The mechanisms mediating the effects are not yet understood; among the candidates are modifications of endogenous hormone levels. Long-term exercise is known to reduce serum levels of growth stimulating hormones. In contrast, the endocrine effects of acute endurance exercise include increased levels of mitogenic factors such as GH and IGF-1. It can be speculated that the elevation of serum growth factors may be detrimental to prostate cancer progression into malignancy. The incentive of the current study is to evaluate the effect of acute exercise serum on prostate cancer cell growth. We designed an exercise intervention where 10 male individuals performed 60 minutes of bicycle exercise at increasing intensity. Serum samples were obtained before (rest serum) and after completed exercise (exercise serum). The established prostate cancer cell line LNCaP was exposed to exercise or rest serum. Exercise serum from 9 out of 10 individuals had a growth inhibitory effect on LNCaP cells. Incubation with pooled exercise serum resulted in a 31% inhibition of LNCaP growth and pre-incubation before subcutaneous injection into SCID mice caused a delay in tumor formation. Serum analyses indicated two possible candidates for the effect; increased levels of IGFBP-1 and reduced levels of EGF. In conclusion, despite the fear of possible detrimental effects of acute exercise serum on tumor cell growth, we show that even the short-term effects seem to add to the overall beneficial influence of exercise on neoplasia.
In memoriam: Robert F. Wagner (1938-2008) (2008)

Robert F. Wagner died on June 30, 2008. During more than forty years of his professional life, he made many contributions to the field of medical imaging and had a significant impact on academia, industry, and government. He has more than 160 publications, many of which are highly cited. Bob was born in Philadelphia, PA in 1938.
Flexible Electroactive Nanomaterials Biotemplated with Versatile M13 Phage Platforms (2013)

Producing electrodes for methanol oxidation using M13 phage as a new support are designed. This electrode shows electroactivity because the M13 phage can direct the size of the metal nanoparticles (NPs) allowing it a good dispersion, building a 3D network. This nanoarchitecture reduces poisoning on the surface of the NPs keeping the electroactivity
Full-Duplex Heterogeneous Networks (2017)

The continuous growth in the numbers of mobile users and the increase in data communication make deploying new techniques with increased data rates a crucial need. In other words, modern network topologies are required to give the required performance boost. Since decreasing the number of users in each cell, as well as decreasing the distance between the users and the base station, increases the total achieved capacity, therefore, small cells are required. However, it is well known that large cells are the cost-effective way to serve fast-moving users. Therefore, one solution to match these demands is to employ Heterogeneous Networks (HetNets). The main idea of HetNets is to densify the existing macro-cell by adding a mix of pico, femto and relay base stations to which users will be offloaded from the macro base station. This will help in increasing the network capacity in hot spots and in giving better coverage for both outdoor and indoor areas not covered by the macro network.
Use of highly polymorphic DNA probes for genotypic analysis following bone marrow transplantation (1986)

The use of DNA markers known as restriction fragment length polymorphisms is a sensitive and informative method of distinguishing patient and allogeneic donor cells after bone marrow transplantation. To apply the test, it is necessary in each case to find DNA probes that display patient-specific and donor-specific bands in Southern transfer hybridization. We have isolated a set of 12 cloned DNAs from highly polymorphic loci by which siblings can usually be distinguished. With just four of these probes, we can expect to distinguish the genotypes of the recipient and a sibling donor in more than 99% of cases (except between identical twins). The availability of many highly polymorphic probes also allows selection of an optimal probe for each case, one that can detect both the patient and donor-specific bands in a single hybridization with maximum resolution and sensitivity. We have applied these probes to the analysis of cells from peripheral blood and bone marrow after transplantation and demonstrated their usefulness in confirming engraftment of donor cells or graft rejection, and in detecting mixed lympho-hematopoietic chimerism.
Self-assembly based on the cyanuric acid-melamine lattice (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelf-assembly based on the cyanuric acid-melamine latticeChristopher T. Seto and George M. WhitesidesCite this: J. Am. Chem. Soc. 1990, 112, 17, 6409–6411Publication Date (Print):August 1, 1990Publication History Published online1 May 2002Published inissue 1 August 1990https://pubs.acs.org/doi/10.1021/ja00173a046https://doi.org/10.1021/ja00173a046research-articleACS PublicationsRequest reuse permissionsArticle Views2046Altmetric-Citations212LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Modeling multicomponent gas separation using hollow‐fiber membrane contactors (1998)

Abstract A model developed for multicomponent gas separation using hollow‐fiber contactors permits simulation of cocurrent, countercurrent, and crossflow contacting patterns with permeate purging (or sweep). The numerical approach proposed permits simulation to much higher stage cuts than previously published work and provides rapid and stable solutions for cases with many components, with widely varying permeability coefficients. This new approach also permits the rational and straightforward incorporation of effects such as permeate sweep, pressure‐dependent permeability coefficients, and bore side pressure gradients. Simulation results are presented for separation of commercially significant multicomponent gas mixtures using polymer permeation properties similar to those of polysulfone. The effect of permeate purging on separation performance is explored for air separation. The influence of pressure ratio on hydrogen separation performance for a refinery stream is presented. Air is modeled as a four‐component mixture of O 2 , N 2 , CO 2 , and H 2 O and the refinery stream contains five components: H 2 , CH 4 , C 2 H 4 , C 2 H 6 , and C 3 H 8 . In air separation, permeate purging with a small fraction of the residue stream provides a very effective method for improving module efficiency for drying but is not efficient for improving nitrogen purity or recovery. In multicomponent mixtures, maxima in the compositions of components of intermediate permeability may be observed as a function of distance along the hollow fiber. This result suggests the use of membrane staging to capture these components at their maximum concentration.
Raman Scattering from Interface Phonons in GaInP/AlInP Superlattice (1994)

Measurements of Raman scattering were performed on ternary alloy superlattices GaInP/AlInP grown by gas-source molecular beam epitaxy. We observed interface phonons whose frequencies are explained in terms of an electrostatic continuum model using the optical phonons of AlInP and GaInP bulk alloys. The Raman intensities of the interface phonons are enhanced when the incident photon energy is close to the exciton energy in the GaInP quantum wells and to the band gap energy in the AlInP. We measured Raman spectra of AlGaInP quaternary alloy, which have the same composition on a standpoint of average crystal structure, and compare it with the spectra of the superlattice.
Evaluation of acute copper toxicity to juvenile freshwater mussels (fatmucket, Lampsilis siliquoidea) in natural and reconstituted waters (2009)

The influence of dissolved organic carbon (DOC) and water composition on the toxicity of copper to juvenile freshwater mussels (fatmucket, Lampsilis siliquoidea) were evaluated in natural and reconstituted waters. Acute 96-h copper toxicity tests werec onducted at four nominal DOC concentrations (0, 2.5, 5, and 10 mg/L as carbon [C]) in dilutions of natural waters and in American Society for Testing and Materials (ASTM) reconstituted hard water. Toxicity tests also were conducted in ASTM soft, moderately hard, hard, and very hard reconstituted waters (nominal hardness 45-300 mg/L as CaCO₃). Three natural surface waters (9.5-11 mg/L DOC) were diluted to obtain a series of DOC concentrations with diluted well water, and an extract of natural organic matter and commercial humic acid was mixed with ASTM hard water to prepare a series of DOC concentrations for toxicity testing. Median effective concentrations (EC50s) for dissolved copper varied >40-fold (9.9 to >396 gg Cu/L) over all 21 treatments in various DOC waters. Within a particular type of DOC water, EC50s increased 5- to 12-fold across DOC concentrations of 0.3 to up to 11 mg C/L. However, EC50s increased by only a factor of 1.4 (21-30 gg Cu/L) in the four ASTM waters with wide range of water hardness (52-300 mg CaCO₃/L). Predictions from the biotic ligand model (BLM) for copper explained nearly 90% of the variability in EC50s. Nearly 70% of BLM-normalized EC50s for fatmucket tested in natural waters were below the final acute value used to derive the U.S. Environmental Protection Agency acute water quality criterion for copper, indicating that the criterion might not be protective of fatmucket and perhaps other mussel species.
Productivity Function (2022)

Although Lean Construction embraces the Lean manufacturing production principles, it still struggles to implement Lean quantitatively. The measurement and thus decision making based on production parameters, such as cycle time and capacity, are yet to be a reality. Among the barriers are instant data collection, the nature of the production processes, and the mathematics that stitch those together, supplying parameters that fit the Lean approach and providing information to decision-makers to manage production according to Lean principles. This chapter aims to propose a mathematically driven production theory to better understand the production mechanisms of repetitive processes in construction project-driven systems. The chapter begins with the existing body of knowledge, establishing a theoretical framework for controlling dynamic production systems management in projects. The chapter progresses to an analytical and scalable method (Productivity Function) to represent the behavior of production systems. The Productivity Function provides a mathematical foundation for calculating cycle times (average, best- and worst-cases), throughput at capacity, and the influence of the transient state time in production variability. The Productivity Function is applied in feedback loop control yielding a robust approach to plan, control, and optimize production. Finally, the chapter presents automated methods of data collection that feed the Productivity Function models.
Design, Synthesis, and Functional Evaluation of CO‐Releasing Molecules Triggered by Penicillin G Amidase as a Model Protease (2015)

Protease-triggered CO-releasing molecules (CORMs) were developed. The viability of the approach was demonstrated through the synthesis of compounds consisting of an η(4) -oxydiene-Fe(CO)3 moiety connected to a penicillin G amidase (PGA)-cleavable unit through a self-immolative linker. The rate of PGA-induced hydrolysis was investigated by HPLC analysis and the subsequent CO release was quantitatively assessed through headspace gas chromatography. In an in vitro assay with human endothelial cells, typical biological effects of CO, that is, inhibition of the inflammatory response and the induction of heme oxygenase-1 expression, were observed only upon co-administration of the CORM and PGA. This work forms a promising basis for the future development of protease-specific CORMs for potential medicinal applications.
Supplementary Table 6 from Somatic <i>ERCC2</i> Mutations Correlate with Cisplatin Sensitivity in Muscle-Invasive Urothelial Carcinoma (2023)

&lt;p&gt;Selective alteration enrichment. This table shows the results of applying Fisher's Exact Test to a tabulated set of predicted damaging somatically altered genes in responders compared to non-responders. A Benjamini-Hochberg/FDR q-value is reported for genes with the minimum number of events necessary to be considered for a theoretically significant p-value of {less than or equal to} 0.01 (n = 6). The results are sorted by p-value (lowest to highest).&lt;/p&gt;
DEFUNCTIONALIZED BLADDERS: EFFECTS BEFORE AND AFTER REFUNCTIONALIZATION IN AN ANIMAL MODEL (2000)

Defunctionalization results in remarkable alterations in bladder growth, capacity, compliance and distribution of connective tissue. However, these bladders demonstrate an innate capacity to recover from these alterations following refunctionalization.
ChemInform Abstract: Two Novel Diterpenoids from Clerodendrum bungei. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Optimization of Amphiphile-Based Colloidal Carriers (2018)

The strategy to design a suitable colloidal carrier is also dependent on other requirements, such as size, surface area, charge, media pH and media ionic strength. The performance of the agent relates to factors which determine the release profile of the agent from the colloidal assembly irrespective of whether the activity requires its release from the carrier. To a large extent, the ability to form a suitable assembly regarding efficiency and stability of agent-loading is dependent on the physicochemical properties of the agent and its mode of interaction with the molecules forming the carrier. Using a simplified approach, all relevant agent properties can be expressed through assortment into several classes. This classification is determined by two partition coefficients: oil/aqueous phase and octanol/aqueous phase. When using the same agent with various types of amphiphile-based carrier it becomes clear that the exact type of the colloidal assembly has a major impact on the performance of the agent associated with the assembly.
Transcriptional profiling reveals a subset of human breast tumors that retain wt TP53 but display mutant p53-associated features (2020)

Abstract TP53 gene mutations are very common in human cancer. While such mutations abrogate the tumor suppressive activities of the wild type (wt) p53 protein, some of them also endow the mutant protein with oncogenic gain-of-function (GOF), facilitating cancer progression. Yet, p53 may acquire altered functionality even without being mutated; in particular, experiments with cultured cells revealed that wt p53 can be rewired to adopt mutant-like features in response to growth factors or cancer-mimicking genetic manipulations. To assess whether such rewiring also occurs in human tumors, we interrogated gene expression profiles and pathway deregulation patterns in the METABRIC breast cancer (BC) dataset as a function of TP53 gene mutation status. Harnessing the power of machine learning, we optimized a gene expression classifier for ER+Her2- patients that distinguishes tumors carrying TP53 mutations from those retaining wt TP53 . Interestingly, a small subset of wt TP53 tumors displayed gene expression and pathway deregulation patterns markedly similar to those of TP53 -mutated tumors. Moreover, similar to TP53 mutated tumors, these “pseudomutant” cases displayed a signature for enhanced proliferation and had worse prognosis than typical wt p53 tumors. Notably, these tumors revealed upregulation of genes which, in BC cell lines, were reported to be positively regulated by p53 GOF mutants. Thus, such tumors may benefit from mutant p53-associated activities without having to accrue TP53 mutations.
Designing interactive voice response (IVR) interfaces: localisation for low literacy users (2009)

In this paper, we address the issue of how to design IVR interfaces for the developing world. Against the backdrop of the following idiosyncratic observations including, the majority of users being either semi-literate or non-literate, and the impact of a different set of social-cultural, linguistic, and domestic challenges, amongst others, we advocate the enculturation of IVR interfaces different from the developed world. This requires the tailoring of functionalities and interactive modalities to the cultural values and context of use. Thus, we propose a dialog (user interface) design model consisting of three components: Get input, Error-recovery, and Play results (output). These are shown to be critical for implementing usable and culturally-suitable IVR interfaces for low-literacy user populations. KEY WORDS Interactive Voice Response (IVR), speech and natural language interfaces, user interface development, low literacy, developing world, localisation. 1.
A Pulsatile-Flow Model for Intracardiac Surgical Device Development (2011)

Percutaneous treatments for heart disease have created new challenges for both physicians and medical device developers and manufacturers. In order to deliver the highest-quality care to patients, developers and physicians must be able to more easily access the intracardiac environment during the initial phases of device development and while learning to implement new tools and methods. We have developed a pulsatile flow model (PFM), which simulates the intracardiac environment using a bellows-pump and closed fluid flow circuit. The PFM is also outfitted with video imaging and other sensors to provide real-time feedback to a user. The PFM was used to aid in the development of a catheter for the percutaneous treatment of mitral regurgitation via chordal cutting. Knowledge gained from tests with the PFM are now being used by a manufacturer to produce catheters, which would be appropriate for more in-depth trials in both animal and human models. The pulsatile flow model provide physicians and manufacturers of cardiac surgical devices a platform for increasing the efficiency of the development process as well as the physicians ability to better treat patients.
Quality-Aware Deep Reinforcement Learning for Streaming in Infrastructure-Assisted Connected Vehicles (2021)

This paper proposes a deep reinforcement learning-based video streaming scheme for mobility-aware vehicular networks, e.g., vehicles on the highway. We consider infrastructure-assisted and mmWave-based scenarios in which the macro base station (MBS) cannot directly provide the streaming service to vehicles due to the short range of mmWave beams so that small mmWave base stations (mBSs) along the road deliver the desired videos to users. For a smoother streaming service, the MBS proactively pushes video chunks to mBSs. This is done to support vehicles that are currently covered and/or will be by each mBS. We formulate the dynamic video delivery scheme that adaptively determines 1) which content, 2) what quality and 3) how many chunks to be proactively delivered from the MBS to mBSs using Markov decision process (MDP). Since it is difficult for the MBS to track all the channel conditions and the network states have extensive dimensions, we adopt the deep deterministic policy gradient (DDPG) algorithm for the DRL-based video delivery scheme. This paper finally shows that the DRL agent learns a streaming policy that pursues high average quality while limiting packet drops, avoiding playback stalls, reducing quality fluctuations and saving backhaul usage.
Use of the FilmArray System for Detection of Zaire ebolavirus in a Small Hospital in Bo, Sierra Leone (2015)

Laboratories associated with small hospitals often have limited expertise, personnel, and equipment to rapidly identify rare and emerging infectious diseases. We describe the successful use of the FilmArray system for rapid detection of Ebola virus directly from clinical samples in 6 out of 83 tested subjects in a small health care center in Sierra Leone.