gebhart/patrepeval huggingface dataset:
Conformational and structural modulation of the NH2-terminal regions of fibrinogen and fibrin associated with plasmin cleavage. (1975)

Conformational and structural modulations of the NH2-terminal region of fibrinogen and fibrin associated with plasmin cleavage have been examined utilizing specific antibody probes. The E region derived from the NH2-terminal aspects of fibrinogen undergoes complex structural and conformational changes throughout the cleavage process as indicated by differences in the quantitative and qualitative expression of antigenic determinants by the E region of each isolated cleavage fragment. When the range of antigenic determinants recognized by the antibody probe is limited to a specific molecular marker on the gamma chain within the E region, fg-E-neo, evidence for a systematic and progressive modulation of this site during plasmin cleavage is observed. Fg-E-neo undergoes progressive exposure as the cleavage of fibrinogen proceeds from X to Y to D:E complex. Separation of the D:E complex into its constituent, D and E fragments, is associated with further exposure of fg-E-neo determinants. The sequential cleavage of fibrin by plasmin also leads to progressive exposure of the fg-E-neo site; however, comparison of corresponding fragments derived from fibrinogen and fibrin reveals significant differences in the character of fg-E-neo expression. Immunochemical differences between fibrin and fibrinogen E fragments are not abolished by further exposure of the fragments to plasmin, are apparently not due to the presence or absence of fibrinopeptides, and are maintained following denaturation and renaturation of the fragments. These results suggest that the differential expression of fg-E-neo by the E fragments may be primarily dependent upon differences in amino acid compositions of the fragments.
Diacerein: Benefits, Risks and Place in the Management of Osteoarthritis. An Opinion-Based Report from the ESCEO (2016)

Diacerein is a symptomatic slow-acting drug in osteoarthritis (SYSADOA) with anti-inflammatory, anti-catabolic and pro-anabolic properties on cartilage and synovial membrane. It has also recently been shown to have protective effects against subchondral bone remodelling. Following the end of the revision procedure by the Pharmacovigilance Risk Assessment Committee of the European Medicines Agency, the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) constituted a panel of 11 experts to better define the real place of diacerein in the armamentarium for treating OA. Based on a literature review of clinical trials and meta-analyses, the ESCEO confirms that the efficacy of diacerein is similar to that of non-steroidal anti-inflammatory drugs (NSAIDs) after the first month of treatment, and superior to that of paracetamol. Additionally, diacerein has shown a prolonged effect on symptoms of several months once treatment was stopped. The use of diacerein is associated with common gastrointestinal disorders such as soft stools and diarrhoea, common mild skin reactions, and, uncommonly, hepatobiliary disorders. However, NSAIDs and paracetamol are known to cause potentially severe hepatic, gastrointestinal, renal, cutaneous and cardiovascular reactions. Therefore, the ESCEO concludes that the benefit-risk balance of diacerein remains positive in the symptomatic treatment of hip and knee osteoarthritis. Furthermore, similarly to other SYSADOAs, the ESCEO positions diacerein as a first-line pharmacological background treatment of osteoarthritis, particularly for patients in whom NSAIDs or paracetamol are contraindicated.
Microwave‐Accelerated Claisen Rearrangements of Allyl Tetronates and Tetramates. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
A topographical model of μ‐opioid and brain somatostatin receptor selective ligands NMR and molecular dynamics studies (1995)

We have refined the 1H NMR-based conformations of the mu-opioid receptor selective peptides related to somatostatin of general formula Xxx-Yyy1-Cys-Zzz-D-Trp-Lys(Orn)5-Thr-Pen-Thr8- NH2, where Xxx, Yyy, Zzz are 0, D-Phe and Tyr for 1; 0, D-Tic and Tyr for 2; Gly, D-Tic and Tyr for 3; and 0, D-Phe and Tic for 4, respectively, (Kazmierski et al., J. Am. Chem. 113, 2275-2283), using a molecular-dynamics approach. We present evidence that the NMR data are compatible with beta II'-, gamma- and gamma'-turns for the central tetrapeptide Tyr-D-Trp-Lys/Orn-Thr. Based on detailed structural and topographical considerations, we suggest that the mu-opioid receptor selectivity of 2 is due to a particular spatial arrangement of aromatic side chains of D-Tic1 and Tyr3 (7.5 A), and that the opioid receptor recognition domain is located in the N-terminal part of the peptide while the somatostatin receptor recognition domain is determined by the central, turn forming part of this class of cyclic peptides. A model for a mu-opioid selective ligand has emerged from these studies that shows excellent structural similarities to rigid opioid alkaloids.
Uteroglobin: A Steroid-Inducible Immunomodulatory Protein That Founded the Secretoglobin Superfamily (2007)

Blastokinin or uteroglobin (UG) is a steroid-inducible, evolutionarily conserved, secreted protein that has been extensively studied from the standpoint of its structure and molecular biology. However, the physiological function(s) of UG still remains elusive. Isolated from the uterus of rabbits during early pregnancy, UG is the founding member of a growing superfamily of proteins called Secretoglobin (Scgb). Numerous studies demonstrated that UG is a multifunctional protein with antiinflammatory/ immunomodulatory properties. It inhibits soluble phospholipase A(2) activity and binds and perhaps sequesters hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids, and prostaglandins. In addition to its antiinflammatory activities, UG manifests antichemotactic, antiallergic, antitumorigenic, and embryonic growth-stimulatory activities. The tissue-specific expression of the UG gene is regulated by several steroid hormones, although a nonsteroid hormone, prolactin, further augments its expression in the uterus. The mucosal epithelia of virtually all organs that communicate with the external environment express UG, and it is present in the blood, urine, and other body fluids. Although the physiological functions of this protein are still under investigation, a single nucleotide polymorphism in the UG gene appears to be associated with several inflammatory/autoimmune diseases. Investigations with UG-knockout mice revealed that the absence of this protein leads to phenotypes that suggest its critical homeostatic role(s) against oxidative damage, inflammation, autoimmunity, and cancer. Recent studies on UG-binding proteins (receptors) provide further insight into the multifunctional nature of this protein. Based on its antiinflammatory and antiallergic properties, UG is a potential drug target.
Correlation of Autofluorescence to Proliferation and Inflammatory Indices in Human Premalignant Colonic Tissues (1998)

Quantitative laser scanning confocal autofluorescence microscopy in premalignant colonic tissues was correlated with cellular proliferation and inflammatory indices. Increasing concentration of low autofluorescence lymphocytes in lamina propria was found to contribute to negative correlation of blue/green autofluorescence to inflammatory index. Modified green autofluorescence might be due to increasing concentration of eosiphils and macrophages. Negative correlation of blue/green autofluorescence to proliferation index was likely due to increasing cell metabolic activity and decreasing accumulated bounded mitochondrial NAD(P)H and flavin. Tissue cutting artifact and aberrant mitochondria might cause weak correlation.
Obinutuzumab: what is there to learn from clinical trials? (2017)

Obinutuzumab (OBZ) is a recombinant type II anti-CD20 and immunoglobulin G1 Fc-optimized monoclonal antibody (mAb), recently approved in chronic lymphocytic leukemia (CLL; B-cell CLL) and follicular lymphoma (FL). Rituximab (RTX) is frequently considered as its "ancestor" and OBZ clinical development was justified by the importance of FcγRIIIA-mediated mechanisms in RTX clinical activity. However, RTX differs from OBZ in 2 critical independent properties: being a type I anti-CD20 mAb and not being Fc-optimized. Moreover, the use of a different dosing regimen for RTX and OBZ further complicates any interpretation of clinical results. The results obtained for OBZ in CLL provide new arguments for FcγRIIIA-mediated mechanisms when the target antigen is expressed at a low density. Results of OBZ in FL confirm the interest for FcγRIIIA-mediated mechanisms, with some limitations, some of them being possibly due to lack of OBZ-induced complement activation. The situation in diffuse large B-cell lymphoma is deceiving, as the possible gains of activity of OBZ appear to be annihilated by the lack of complement activation. Although RTX was by chance an anti-CD20 mAb with equilibrated pharmacodynamic properties, the reinforcement of some of these properties, which has been done at the expense of complement activation, has conferred an advantage in some B-cell disorders while restricting OBZ indications. The OBZ story nicely demonstrates that the future of naked mAbs is to design agents with optimized and tailored properties, and that this must be done step by step, with a full clinical validation.
ADAMTS13 Improving the Cell Engraftment Efficacy in Mouse Model of Bone Marrow Transplantation (2012)

Abstract Abstract 1077 The adhesive protein von Willebrand factor (VWF) plays an essential role on physiologic hemostasis, mediating platelet aggregation under high shear stress conditions. However excessive functions of VWF could cause thrombotic occlusion of microvasculature such as arterial capillaries, where blood flow creates a typical high shear stress. The VWF-cleaving protease ADAMTS13 is therefore thought to down-regulate precisely the VWF function to maintain enriched microcirculation. In this context, we hypothesized that this ADAMTS13 role might contribute to better donor cell homing and engraftment in various cell therapy approaches, in which fluent blood flow could be critical in the microcirculation system. To test this hypothesis, we investigated the essential role of ADAMTS13 on the donor cell engraftment using bone marrow transplantation (BMT) model in Adamts13 −/− and wild-type mice. Irradiated recipient mice were received 2 × 106 GFP positive cells from the sex-matched GFP donor mice. All of irradiated recipient mice without receiving BMT died within 21 days. Although there is no difference between Adamts13 −/− and wild-type mice in survival rate after 7days of BMT, Kaplan-Meier analysis revealed that the percent ratio of survival rate starts significantly declining after 14 days of BMT in the group of Adamts13 −/− mice. The successful cell engraftment in BMT was assessed by the number of GFP-positive neutrophils in peripheral blood at the several time points from BMT. As a result, the duration achieving the number of GFP-positive neutrophils over 500/μL was found to significantly delay in the Adamts13 −/− mice, as compared with the wild-type mice (20.2±3.8 days vs. 14.4±3.3 days). However, histological examination during the whole observation periods could not detect any typical thrombotic lesions of micro vessels developed in both wild-type and Adamts13 −/− mice. In addition, the delayed cell engraftment observed in the Adamts13 −/− mice became normalized by the bolus administration of recombinant ADAMTS13 (10 μg/mouse) at the day 0 of BMT. Bone marrow analysis at the day 1 of BMT revealed that the number of GFP-positive blood cells in bone marrow was significantly reduced in the Adamts13 −/− mice as compared with the wild-type mice, which could result in the delayed cell expansion at the day 7 and day14 of BMT in Adamts13 −/− mice. The single bolus injection of recombinant ADAMTS13 was found to fully correct the delayed cell expansion in bone marrow in the Adamts13 −/− mice. Our results indicate that the regulation of VWF-mediated thrombotic or inflammatory responses by ADAMTS13 could contribute to better microcirculation which could be critical for efficient donor cell homing and engraftment in BMT, suggesting a therapeutic potential of ADAMTS13 in cell therapy approaches. Disclosures: Soejima: The Chemo-Sero-Therapeutic Research Institute: Employment.
A Comprehensive Study on Mo/CdTe Metal-Semiconductor Interface Deposited by Radio Frequency Magnetron Sputtering (2015)

Metal-semiconductor (MS) junction between Mo and CdTe, which is one of the fundamental issues for CdTe based solar cell, has been investigated for films deposited on different substrates. XRD pattern of Mo/CdTe films on the polyimide (PI) substrate shows a strong preferential orientation of MoTe2 in (100) at 2θ = 29.44 degrees, which becomes less apparent as deposition time of CdTe increases. However, on soda lime glass (SLG) no such XRD reflection pattern is observed. Moreover, from EDX measurement, Mo-Te compound also identifies MoTe2 at Mo/CdTe interface on PI substrate, which is not present on SLG. Bulk carrier concentration of Mo/CdTe films on PI substrate for lower deposition time of CdTe is found 1.42 x 10(18) cm(-3), which is almost equal to MoTe2. Thereafter, it decreases as CdTe growth time increases. The type of unintentionally formed MoTe2 on PI substrate is found to be n-type in nature. Lattice constants of a = 6.5 Å for CdTe and a = 3.52 Å for MoTe2 are found from nanostructure study by TEM.
ChemInform Abstract: NEW PROCEDURE FOR THE CHLORINATION OF PYRIMIDINE AND PURINE NUCLEOSIDES (1981)

Abstract Bei der Behandlung mit m‐Chlorperbenzoesäure (MCPBA) und Dimethylformamid oder Dimethylacetamid und HCl erhält man aus den Pyrimidin‐ (I) und Purin‐Nucleosiden (III) die entsprechenden Chlorierungsprodukte (II) und (IV).
Principles of Locality-Aware Networks for Locating Nearest Copies of Data (2003)

Building overlay network tools for locating information in a manner that exhibits localityawareness is crucial for the viability of large internets. It means that costs are proportional to the actual distance of interacting parties, and in many cases, that load may be contained locally. This paper presents a step-by-step decomposition of several locality-aware networks, that support distributed content-based location services. It explains their common principles and their variations with simple and clear analysis.
Performance of electrophoretic deposited low voltage phosphors for full color field emission display devices (1999)

Electrophoretic deposition of low voltage phosphors was successfully carried out on patterned indium–tin–oxide glass in order to develop prototype full color field emission display devices. The optimized suspension consisted of 2–3 μm size color phosphors in isopropyl alcohol, and mixed La(NO3)2 and Al(NO3)2 salts for the best display panel images. The ZnS:Cu, Al, ZnS:Ag, Cl, and Y2O2S:Eu phosphors were used to produce primary green, blue, and red colors, respectively. The compositional and structural analysis of the phosphors was performed and basic deposition parameters, such as deposition time and applied voltages, were systematically investigated in order to obtain the desirable brightness in real panels. A uniform thickness of about 4–9 μm was achieved over a whole 4 in. glass plate, depending on the electrical properties of each phosphor. Finally, the deposited phosphors were extensively characterized by a scanning electron microscopy, three-dimensional surface analysis.
A Highly-Efficient Doherty Power Amplifier With Generalized Parallel-Circuit Class-EF Mode (2023)

In this brief, a highly-efficient Doherty power amplifier (DPA) architecture with generalized parallel-circuit class-EF mode is proposed. With this topology, the ideal harmonic impedance conditions at the deep power back-off (PBO) region and saturation region can remain the same. Based on it, by adding a single harmonic control network (HCN) and an offset line, the carrier PA can be operated at the ideal high-efficiency conditions within the above two regions. In this case, the overall efficiency of the DPA can be improved simultaneously. As an example, a high-efficiency DPA working at 2.6 GHz is designed and fabricated based on a Wolfspeed CGH40010F GaN HEMT transistor. The measured results of the proposed structure demonstrated that a drain efficiency (DE) of 76.7% with the peak outpower of 45.2 dBm, as well as DE of 74.8% at the 6dB power back off region.
Finite-difference time-domain simulation of ultrafast events in nonlinear, Fabry-Perot resonators (1993)

We model optical fields in nonlinear thin film resonators by numerical integration of the dispersive Maxwell equations. We explore the use of non-linear resonators to extract pulse shapes from ultra-fast fields and the use of pulsed images to create spatial patterns in nonlinear resonators.
Recruitment of Effector T Lymphocytes Against a Tumor Allograft by T Lymphocytes Sensitized In Vitro2 (1973)

Journal Article Recruitment of Effector T Lymphocytes Against a Tumor Allograft by T Lymphocytes Sensitized In Vitro Get access Abraham J. Treves, Abraham J. Treves Search for other works by this author on: Oxford Academic PubMed Google Scholar Irun R. Cohen Irun R. Cohen Department of Cell Biology, The Welzmann Institute of Science, Rehovot, Israel Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 51, Issue 6, December 1973, Pages 1919–1925, https://doi.org/10.1093/jnci/51.6.1919 Published: 01 December 1973 Article history Received: 31 May 1973 Accepted: 08 August 1973 Published: 01 December 1973
Learning Interpretable Spatial Operations in a Rich 3D Blocks World (2018)

In this paper, we study the problem of mapping natural language instructions to complex spatial actions in a 3D blocks world. We first introduce a new dataset that pairs complex 3D spatial operations to rich natural language descriptions that require complex spatial and pragmatic interpretations such as “mirroring”, “twisting”, and “balancing”. This dataset, built on the simulation environment of Bisk, Yuret, and Marcu (2016), attains language that is significantly richer and more complex, while also doubling the size of the original dataset in the 2D environment with 100 new world configurations and 250,000 tokens. In addition, we propose a new neural architecture that achieves competitive results while automatically discovering an inventory of interpretable spatial operations (Figure 5).
Oligothia Dendrimers for the Formation of Gold Nanoparticles (2004)

Abstract The synthesis and characterization of oligothia dendrimers and their use for the formation of gold nanoparticles is described. The role played by these dendrimers in controlling the stability and size of the particles is discussed. It is shown that the generation of the dendrimers, as well as the position of the sulfur atoms in the dendritic structure (S 6 G1 and S 9 G1), influence the formation and reactivity of the nanoparticles. UV‐visible spectroscopy, 1 H nuclear magnetic resonance spectroscopy and high‐resolution transmission electron microscopy have been employed for the characterization of the nanoparticles. Furthermore, purification by Soxhlet extraction has been performed.
Data from Anti-BCMA/CD19 CAR T Cells with Early Immunomodulatory Maintenance for Multiple Myeloma Responding to Initial or Later-Line Therapy (2023)

&lt;div&gt;Abstract&lt;p&gt;We conducted a phase I clinical trial of anti-BCMA chimeric antigen receptor T cells (CART-BCMA) with or without anti-CD19 CAR T cells (huCART19) in multiple myeloma (MM) patients responding to third- or later-line therapy (phase A, &lt;i&gt;N&lt;/i&gt; = 10) or high-risk patients responding to first-line therapy (phase B, &lt;i&gt;N&lt;/i&gt; = 20), followed by early lenalidomide or pomalidomide maintenance. We observed no high-grade cytokine release syndrome (CRS) and only one instance of low-grade neurologic toxicity. Among 15 subjects with measurable disease, 10 exhibited partial response (PR) or better; among 26 subjects responding to prior therapy, 9 improved their response category and 4 converted to minimal residual disease (MRD)–negative complete response/stringent complete response. Early maintenance therapy was safe, feasible, and coincided in some patients with CAR T-cell reexpansion and late-onset, durable clinical response. Outcomes with CART-BCMA + huCART19 were similar to CART-BCMA alone. Collectively, our results demonstrate favorable safety, pharmacokinetics, and antimyeloma activity of dual-target CAR T-cell therapy in early lines of MM treatment.&lt;/p&gt;Significance:&lt;p&gt;CAR T cells in early lines of MM therapy could be safer and more effective than in the advanced setting, where prior studies have focused. We evaluated the safety, pharmacokinetics, and efficacy of CAR T cells in patients with low disease burden, responding to current therapy, combined with standard maintenance therapy.&lt;/p&gt;&lt;p&gt;&lt;i&gt;&lt;a href="https://aacrjournals.org/bloodcancerdiscov/article/doi/10.1158/2643-3230.BCD-4-2-ITI" target="_blank"&gt;This article is highlighted in the In This Issue feature, p. 101&lt;/a&gt;&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
Supplementary Figure 7 from Cisplatin Selects for Multidrug-Resistant CD133<sup>+</sup> Cells in Lung Adenocarcinoma by Activating Notch Signaling (2023)

&lt;p&gt;PDF file - 138K, The role of Notch signaling in enrichment of CD133+ cells and multi-drug resistance of H661 cells&lt;/p&gt;
Lasing Action with Gold Nanorod Hyperbolic Metamaterials (2017)

Coherent nanoscale photon sources are of paramount importance to achieving all-optical communication. Several nanolasers smaller than the diffraction limit have been theoretically proposed and experimentally demonstrated using plasmonic cavities to confine optical fields. Such compact cavities exhibit a strong Purcell effect, thereby enhancing spontaneous emission, which feeds into the lasing modes. However, most plasmonic nanolasers reported so far have employed relatively narrowband resonant nanostructures and therefore had the lasing restricted to the proximity of the resonance wavelength. Here, we report on an approach based on gold nanorod hyperbolic metamaterials for lasing. Hyperbolic metamaterials provide broadband Purcell enhancement due to the large photonic density of optical states, while also supporting surface plasmon modes to deliver optical feedback for lasing due to nonlocal effects in nanorod media. We experimentally demonstrate the advantage of hyperbolic metamaterials in achieving lasing action by its comparison with that obtained in a metamaterial with elliptic dispersion. The conclusions from the experimental results are supported with numerical simulations comparing the Purcell factors, surface plasmon modes, and spontaneous emission factors for the metamaterials with different dispersions. We show that although the metamaterials of both types support lasing, emission with hyperbolic samples is about twice as strong with 35% lower threshold versus the elliptic ones. Hence, hyperbolic metamaterials can serve as a convenient platform of choice for nanoscale coherent photon sources in a broad wavelength range.