gebhart/patrepeval huggingface dataset:
Color‐Tunable Boron‐Based Emitters Exhibiting Aggregation‐Induced Emission and Thermally Activated Delayed Fluorescence for Efficient Solution‐Processable Nondoped Deep‐Blue to Sky‐Blue OLEDs (2020)

Abstract Three new color‐tunable (deep‐blue to sky‐blue) and solution‐processable emitters—9′‐(2,12‐di‐ tert ‐butyl‐5,9‐dioxa‐13 b ‐boranaphtho[3,2,1‐ de ]anthracen‐7‐yl)‐9′ H ‐9,3′:6′,9″‐tercarbazole ( TB‐3Cz) , 9′‐(2,12‐di‐ tert ‐butyl‐5,9‐dioxa‐13 b ‐boranaphtho[3,2,1‐ de ]anthracen‐7‐yl)‐9,9″‐diphenyl‐9 H ,9′ H ,9″ H ‐3,3′:6′,3″‐tercarbazole ( TB‐P3Cz) , and 9‐(2,12‐di‐ tert ‐butyl‐5,9‐dioxa‐13 b ‐boranaphtho[3,2,1‐ de ]anthracen‐7‐yl)‐ N 3 , N 3 , N 6 , N 6 ‐tetraphenyl‐9 H ‐carbazole‐3,6‐diamine ( TB‐DACz) —are demonstrated, which are cleverly designed and synthesized by appending a boron‐fused entity as an electron acceptor to different electron‐rich entities containing carbazole derivatives as donors. The thermal, photophysical, electrochemical, and electroluminescent characteristics of all the new materials are extensively investigated. Comprehensive photophysical investigations reveal that these emitters exhibit not only thermally activated delayed fluorescence (TADF) but also aggregation‐induced emission (AIE) properties. Consequently, solution‐processable organic light‐emitting diodes (OLEDs) fabricated using these new materials as nondoped emitters in the emissive layer exhibit a maximum external quantum efficiency (EQE) and Commission Internationale de l'Éclairage (CIE) color coordinates of 9.90% and (0.17, 0.07), respectively, for TB‐3Cz ; 6.13% and (0.15, 0.08), respectively, for TB‐P3Cz ; and 6.04% and (0.18, 0.40), respectively, for TB‐DACz . As far as it is known, the performance and ultrahigh color purity satisfying the deep‐blue CIE coordinates of the National Television System Committee (NTSC) for TB‐3Cz and TB‐P3Cz are the highest reported thus far for nondoped solution‐processable TADF emitters, indicating the great potential of these materials as deep‐blue luminogens in OLED applications.
Amelioration of Proximal Renal Tubular Dysfunction in Type I Glycogen Storage Disease with Dietary Therapy (1990)

IN Type I glycogen storage disease, glycogen accumulates in the liver, kidney, and intestine because of deficient glucose-6-phosphatase activity (Type Ia) or deficient glucose-6-phosphate transloca...
Portugal (1986)

Over the period 1974–82 the total population of Portugal increased from 8,650,000 to 9,540,000, an increase of 10.3 per cent (Table 13.1).
Demonstration of optical interference filters utilizing tunable refractive index layers (2010)

Optical interference filters utilizing tunable refractive index layers are shown to have higher spectral fidelity as compared to conventional filters consisting of non-tunable refractive index layers. To demonstrate this increase in spectral fidelity, we design and compare a variety of optical interference filters employing both tunable and non-tunable refractive index layers. Additionally, a five-layer optical interference filter utilizing tunable refractive index layers is designed and fabricated for use with a Xenon lamp to replicate the Air Mass 0 solar irradiance spectrum and is shown to have excellent spectral fidelity.
Imaging of Tie2 with a Fluorescently Labeled Small Molecule Affinity Ligand (2019)

The receptor tyrosine kinase inhibitor, Tie2, has significant roles in endothelial signaling and angiogenesis and is relevant in the pathophysiology of several diseases. However, there are relatively few small molecule probes available to study Tie2, making the evaluation of its activity in vivo difficult. Recently, it was discovered that the small molecule rebastinib (DCC-2036) is a potent Tie2 inhibitor. We hypothesized that fluorescent derivatives of rebastinib could be used as imaging agents for Tie2. On the basis of crystallography structures, we synthesized three fluorescent derivatives, which we then evaluated in both in vitro and in vivo assays. We found that the Rebastinib-BODIPY TMR (Reb-TMR) derivative has superior imaging characteristics in vitro, and we successfully labeled endothelial cells in vivo. We propose that this probe could be further used in in vivo applications for studying the role of Tie2 in disease.
Using Peptide Arrays to Profile Phosphatase Activity in Cell Lysates (2019)

Phosphorylation is an important post-translational modification on proteins involved in many cellular processes; however, understanding of the regulation and mechanisms of global phosphorylation remains limited. Herein, we utilize self-assembled monolayers on gold for matrix-assisted laser desorption/ionization mass spectrometry (SAMDI-MS) with three phosphorylated peptide arrays to profile global phosphatase activity in cell lysates derived from five mammalian cell lines. Our results reveal significant differences in the activities of protein phosphatases on phospho- serine, threonine, and tyrosine substrates and suggest that phosphatases play a much larger role in the regulation of global phosphorylation on proteins than previously understood.
Self-assembled monolayers of alkanethiols on gold: comparisons of monolayers containing mixtures of short- and long-chain constituents with methyl and hydroxymethyl terminal groups (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelf-assembled monolayers of alkanethiols on gold: comparisons of monolayers containing mixtures of short- and long-chain constituents with methyl and hydroxymethyl terminal groupsJohn P. Folkers, Paul E. Laibinis, and George M. WhitesidesCite this: Langmuir 1992, 8, 5, 1330–1341Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published inissue 1 May 1992https://doi.org/10.1021/la00041a015Request reuse permissionsArticle Views2644Altmetric-Citations359LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (4 MB) Get e-Alertsclose Get e-Alerts
Computational Fluid Dynamics Analysis of Blade Tip Clearances on Hemodynamic Performance and Blood Damage in a Centrifugal Ventricular Assist Device (2009)

An important challenge facing the design of turbodynamic ventricular assist devices (VADs) intended for long-term support is the optimization of the flow path geometry to maximize hydraulic performance while minimizing shear-stress-induced hemolysis and thrombosis. For unshrouded centrifugal, mixed-flow and axial-flow blood pumps, the complex flow patterns within the blade tip clearance between the lengthwise upper surface of the rotating impeller blades and the stationary pump housing have a dramatic effect on both the hydrodynamic performance and the blood damage production. Detailed computational fluid dynamics (CFD) analyses were performed in this study to investigate such flow behavior in blade tip clearance region for a centrifugal blood pump representing a scaled-up version of a prototype pediatric VAD. Nominal flow conditions were analyzed at a flow rate of 2.5 L/min and rotor speed of 3000 rpm with three blade tip clearances of 50, 100, and 200 microm. CFD simulations predicted a decrease in the averaged tip leakage flow rate and an increase in pump head and axial thrust with decreasing blade tip clearances from 200 to 50 microm. The predicted hemolysis, however, exhibited a unimodal relationship, having a minimum at 100 microm compared to 50 microm and 200 microm. Experimental data corroborate these predictions. Detailed flow patterns observed in this study revealed interesting fluid dynamic features associated with the blade tip clearances, such as the generation and dissipation of tip leakage vortex and its interaction with the primary flow in the blade-blade passages. Quantitative calculations suggested the existence of an optimal blade tip clearance by which hydraulic efficiency can be maximized and hemolysis minimized.
Soft‐Lithographically Embossed, Multilayered Distributed‐Feedback Nanocrystal Lasers (2004)

Multiple-wavelength distributed-feedback lasers are made from multilayered composites by utilizing the solution-processing ease of cadmium selenide semiconductor nanocrystals and soft lithography. The Figure shows three types of emission obtained from such structures across a wide range of the visible spectrum: fluorescence (dotted lines), amplified spontaneous emission (dashed lines), and feedback-induced lasing (solid lines).
Prospective Prognostic Assessment of Blood Pressure Response During Exercise in Patients With Hypertrophic Cardiomyopathy (1997)

A normal exercise blood pressure response identifies low-risk young patients with HCM. An ABPR identifies the high-risk cohort; the low positive predictive accuracy, however, indicates that further risk stratification is warranted.
Dentritic Cell-Targeted Phage Vectors for Breast Cancer Vaccine (2004)

Abstract : We hypothesize that one can use specific protein or peptide sequences to direct bacteriophage vectors to dendritic cells. We further propose that one can then use such retargeted phage vectors to deliver potentially important antigens to dendritic cells (DC), and that this may allow one to derive vectors capable of eliciting potent immune responses to breast cancer antigens such as her2. These hypotheses are being experimentally tested. During the period covered by this progress report, we have constructed modified lambda phage coat proteins which contain an array of receptor-binding/cell-targeting peptides which are expected to target receptors present on DC. Many of these have high affinities (nanomolar range) for their cognate ligands. We have also constructed modified lambda coat proteins which can be readily coupled to antibody molecules of interest, using engineered lgG binding domains. Finally, we have isolated scFvs that interact with human DC-SIGN on an ELISA assay, and we have generated purified lambda phage particles which contain our modified coat proteins.
Mechanisms of freezing tolerance in an Antarctic midge, Belgica antarctica (1979)

ABSTRACT. The larvae and adults of Belgica antarctica were studied in an attempt to identify the mechanism of low temperature adaptation that enables this species to survive in the Antarctic. Larvae are freezing‐tolerant during the austral summer and elaborate a complex of cryoprotectants including erythritol, glucose, sucrose and trehalose. Adults are freezing‐susceptible and lack adequate quantities of cryoprotectants. Maintenance on artificial diets indicated that cryoprotectant profiles have food‐source and temperature‐dependent components. In addition, direct utilization of dietary cryoprotectants is suggested.
ChemInform Abstract: Concise Synthesis of Optically Active Ring‐A Substituted Tryptophans. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Hip in Ice Hockey: A Current Concepts Review (2016)

Ice hockey is a fast, physical sport with unique associated biomechanical demands often placing the hip in forced and repetitive supraphysiological ranges of motion. Ice hockey players commonly endure and are sidelined by nebulous groin injury or hip pain. Underlying causes can be chronic or acute and extra-articular, intra-articular, or "hip-mimicking." This article serves to review common hip-related injuries in ice hockey. For each, we define the particular condition; comment on risk factors and preventive strategies; discuss key historical, physical examination, and imaging findings; and finally, suggest nonoperative and/or operative treatment plans.
Resonance Energy Transfer-Based Biosensors for Point-of-Need Diagnosis—Progress and Perspectives (2021)

The demand for point-of-need (PON) diagnostics for clinical and other applications is continuing to grow. Much of this demand is currently serviced by biosensors, which combine a bioanalytical sensing element with a transducing device that reports results to the user. Ideally, such devices are easy to use and do not require special skills of the end user. Application-dependent, PON devices may need to be capable of measuring low levels of analytes very rapidly, and it is often helpful if they are also portable. To date, only two transduction modalities, colorimetric lateral flow immunoassays (LFIs) and electrochemical assays, fully meet these requirements and have been widely adopted at the point-of-need. These modalities are either non-quantitative (LFIs) or highly analyte-specific (electrochemical glucose meters), therefore requiring considerable modification if they are to be co-opted for measuring other biomarkers. Förster Resonance Energy Transfer (RET)-based biosensors incorporate a quantitative and highly versatile transduction modality that has been extensively used in biomedical research laboratories. RET-biosensors have not yet been applied at the point-of-need despite its advantages over other established techniques. In this review, we explore and discuss recent developments in the translation of RET-biosensors for PON diagnoses, including their potential benefits and drawbacks.
High-Throughput Large-Aperture Prism Prefilter for Ultraviolet Resonance Raman Spectroscopy (1998)

For the acquisition of high-quality ultraviolet resonance Raman spectra of strongly scattering samples such as membrane protein suspensions, an f/3.5 Littrow prism prefilter has been designed, built, and characterized. This prefilter has a Czerny–Turner configuration, and its focal length is 25 cm. The apex angle of the dispersive prism (20°) was chosen to provide maximum performance in the 220 to 240 nm range. The prism prefilter significantly reduced stray background due to Rayleigh scattering and visible fluorescence, while maintaining a low dispersion of 1300 cm −1 /mm at 253 nm as well as a large f/3.5 aperture. The sharpness of the transmission edge (at 242 nm, the T = 0% to 95% transition occurs in 1.3 nm) quantitates its effectiveness as a sharp-cut Rayleigh scattering filter. The total throughput of the prefilter is ∼60% at 235 nm and ∼50% at 632.8 nm. The utility of this prefilter is demonstrated by obtaining high signal-to-noise resonance Raman spectra of bacteriorhodopsin in a purple membrane suspension with 239.5 nm excitation.
Electrodeposition of Both Carbon Nanotube and Glucose Oxidase on Pt Eectrode Using a Dispersed Electrolytic Solution (2018)

Immobilization of the enzyme is one of the most critical processes for the fabrication of an enzyme sensor, since it will highly influence properties of the obtained sensor. Various procedure have been proposed for a the preparation of glucose sensor, such as covalent attachment, cross-linking, hydrogel entrapment, polymer film entrapment, and the combination of two or more methods. Among the various techniques, the electrodeposition method is interesting owing to its simple preparation, miniaturization, and precise localization of enzyme. On the other hand, nanocarbons (NCs), such as carbon nanotubes (CNTs) and graphenes, are extremely attractive in biosensor application, since they can combine properties of the high surface area, high stability and good electrical conductivity. However, NCs is not soluble in aqueous solution, which is the least media to dissolve enzyme without reducing its activity. The use of surfactants is a candidate to preparer a disperse NCs in enzyme solution, while this may also reduce the enzyme activity. Therefore, processes of enzyme immobilization and NCs immobilization are commonly performed separately using different solutions. In this study, stable dispersed solutions of glucose oxidase (GOx) and multi-walled CNT were developed using gellan gum, which is a polysaccharide manufactured by microbial fermentation used widely as a gelling agents. By using this CNT/GOx dispersed solution, both CNT and GOx were successfully immobilized on Pt-Ir electrode by a simple step of applying a constant potential of 1.3 V（vs. Ag/AgCl) to the electrode in this solution. The electropolymerization of o -phenylenediamine was followed in order to increase the stability of enzyme-immobilized electrode. The CNT/GOx immobilized electrode performed as a glucose sensor with a high sensor sensitivity. This indicate that the introduction of CNT in GOx-immobilized film increased the efficiency of electron transfer between the electrode and generated hydrogen peroxide. In addition, the reproducibility of electrode fabrication was satisfactorily improved by the use of gellan gum compared with that using Triton X-100 as a dispersing agent.
A Prospective Observational Study of the Effect of Penicillin Skin Testing on Antibiotic Use in the Intensive Care Unit (2003)

The PST is a safe, reliable, and effective strategy to reduce the use of non-beta-lactam antimicrobials in patients who are labeled as penicillin allergic and admitted to the ICU.
Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs (2023)

The high prevalence of debilitating joint diseases like osteoarthritis (OA) poses a high socioeconomic burden. Currently, the available drugs that target joint disorders are mostly palliative. The unmet need for effective disease-modifying OA drugs (DMOADs) has been primarily caused by the absence of appropriate models for studying the disease mechanisms and testing potential DMOADs. Herein, we describe the establishment of a miniature synovial joint-mimicking microphysiological system (miniJoint) comprising adipose, fibrous, and osteochondral tissue components derived from human mesenchymal stem cells (MSCs). To obtain the three-dimensional (3D) microtissues, MSCs were encapsulated in photocrosslinkable methacrylated gelatin before or following differentiation. The cell-laden tissue constructs were then integrated into a 3D-printed bioreactor, forming the miniJoint. Separate flows of osteogenic, fibrogenic, and adipogenic media were introduced to maintain the respective tissue phenotypes. A commonly shared stream was perfused through the cartilage, synovial, and adipose tissues to enable tissue crosstalk. This flow pattern allows the induction of perturbations in one or more of the tissue components for mechanistic studies. Furthermore, potential DMOADs can be tested via either "systemic administration" through all the medium streams or "intraarticular administration" by adding the drugs to only the shared "synovial fluid"-simulating flow. Thus, the miniJoint can serve as a versatile in vitro platform for efficiently studying disease mechanisms and testing drugs in personalized medicine.
Optimal Filler Sizes for Thermal Interface Materials (2019)

The principal challenge in developing a new thermal interface material (TIM)is to co-design its micro-attributes (e.g. filler type, packing fraction, size distribution)that simultaneously ensure high effective thermal conductivity (keff), low elastic modulus (Eeff) and low viscosity (ηeff). Today there exists little physical insight into size distributions of fillers that would optimize desired properties. These thermomechanical metrics follow contradicting trends if filler content is only monotonically increased. In this paper, we elucidate microstructure-property correlations vital for optimizing effective properties. First, we systematically vary filler size distributions and generate different particulate structures with a previously developed packing algorithm [1]. Then, we employ mechanistic models, based upon physics of microscale heat/force transport, to predict keff, Eeff and ηeff of the particulate structure, thereby identifying filler size domains that optimize the desired properties.
5-11 μm Supercontinuum Generation Using Cascaded Nonlinearities in Fluoride Fiber and ZGP (2021)

We present a femtosecond-pumped, octave-spanning, FTIR-compatible supercontinu-um covering 5-11 μm. The SC is generated with record efficiency in ZGP through intra-pulse DFG of a spectrally broaden fiber laser with a 15-fs pulse centered around 2-μm.
Inhibitory effects of OKY-046 on spasmogen-induced bronchoconstrictions in sensitized and non-sensitized guinea pigs. (1990)

We examined the effect of thromboxane A2 (TXA2) synthetase inhibitor, OKY-046, on bronchoconstriction induced by antigen and various spasmogenic mediators in guinea pigs in vivo. Further, inhibitory activities of OKY-046 on contractions of isolated tracheae and lung parenchymal strips induced by various contractile agents were also investigated in vitro. OKY-046, but not indomethacin, significantly inhibited antigen-induced bronchoconstriction in a dose-dependent manner. Moreover, OKY-046 attenuated bronchoconstrictions induced by peptide leukotrienes (LTs) and platelet activating factor (PAF), but not those by histamine, prostaglandin D2 (PGD2) and STA2 (a stable TXA2 mimetic agent). Although contractile responses induced by spasmogens such as peptide LTs, PAF and histamine were not influenced by OKY-046 in isolated tracheae, OKY-046 elicited significant and concentration-dependent inhibitions against contractile responses induced by peptide LTs and PAF in isolated lung parenchymal strips. These results suggest the possible involvement of TXA2 in the development of anaphylactic bronchoconstriction in sensitized guinea pigs.
The immune system: taming and unleashing cancer. (2006)

The immune system usually detects and destroys pre-malignant cells, which are cells that have initiated oncogenic transformation. To fulfill this role, the immune system must distinguish between normal and transformed cells rather than between self and non-self. A large body of novel research studies illuminates the close relation between immunosurveillance and oncogenesis, suggesting new strategies for reestablishing the immune response against established tumors.