gebhart/patrepeval huggingface dataset:
Brain kininogen following experimental brain injury: evidence for a secondary event (1989)

✓ Previous studies have shown that following experimental brain injury cerebral arterioles dilate and display endothelial lesions and reduced responsiveness to hypocapnia. These abnormalities are caused by cyclooxygenase-dependent free radical generation. There is evidence that the kallikrein-kinin system may in part stimulate the cyclooxygenase-dependent damage since bradykinin is a powerful stimulator of prostaglandin formation and it has recently been shown that a specific kinin receptor blocker decreases the arteriolar abnormalities caused by injury. In order to further examine the hypothesis that the kallikrein-kinin system is important in inducing damage, rat brain tissue was examined for kininogen, the precursor of kinins, at 10 minutes and 1, 3, 6, 15, 24, 48, and 72 hours after injury. A fluid-percussion brain injury device was attached over the right cerebral cortex of rats and a 1.6-atmosphere pressure injury was administered. The kininogen content was determined by a radioimmunoassay procedure in tissues which were free of intravascular blood. After injury, bleeding was confined mainly to the right hemisphere. The kininogen content in the right hemisphere was significantly elevated by one hour after injury, continued to rise until 15 hours after injury, then was significantly decreased by 2 days after injury. In the left hemisphere, kininogen was significantly elevated at 1 hour postinjury, returned toward control levels over the 3- to 6-hour period after injury, then was again elevated at 15 hours after injury. These studies also show that brain water and cerebrovascular permeability were greater at 15 hours postinjury than at earlier time points. The data further support a role for the kallikrein-kinin system in brain injury and, when considered with the results of other studies, suggest that a secondary event is occurring in the 12- to 24-hour period after neural injury. The authors hypothesize that this secondary event is related to endothelial and vascular repair and may be important for the return of normal cerebrovascular function.
Analyses of Substrate-Dependent Broadband Microwave (1–40 GHz) Dielectric Properties of Pulsed Laser Deposited Ba0.5Sr0.5TiO3 Films (2021)

Ba0.5Sr0.5TiO3 (BST-0.5) thin films (600 nm) were deposited on single crystal MgO, SrTiO3 (STO), and LaAlO3 (LAO) substrates by pulsed laser deposition at an oxygen partial pressure of 80 mTorr and temperature of 720 °C. X-ray diffraction and in situ reflection high-energy electron diffraction routinely ascertained the epitaxial quality of the (100)-oriented nanocrystalline films. The broadband microwave (1–40 GHz) dielectric properties were measured using coplanar waveguide transmission line test structures. The out-of-plane relative permittivity (ε⏊/) exhibited strong substrate-dependent dielectric (relaxation) dispersions with their attendant peaks in loss tangent (tanδ), with the former dropping sharply from tens of thousands to ~1000 by 10 GHz. Although homogeneous in-plane strain (ϵǁ), enhances ε⏊/ with εMgOBST−0.5⏊/&gt;εSTOBST−0.5⏊/&gt;εLAOBST−0.5⏊/ at lower frequencies, two crossover points at 8.6 GHz and 18 GHz eventually change the trend to: εSTOBST−0.5⏊/&gt;εLAOBST−0.5⏊/&gt;εMgOBST−0.5⏊/. The dispersions are qualitatively interpreted using (a) theoretically calculated (T)−(ϵǁ) phase diagram for single crystal and single domain BST-0.5 film, (b) theoretically predicted ϵǁ-dependent, ε⏊/ anomaly that does not account for frequency dependence, and (c) literature reports on intrinsic and extrinsic microstructural effects, including defects-induced inhomogeneous strain and strain gradients. From the Vendik and Zubko model, the defect parameter metric, ξs, was estimated to be 0.51 at 40 GHz for BST-0.5 film on STO.
ChemInform Abstract: Intermolecular Pinacol Cross Coupling of Electronically Similar Aldehydes. An Efficient and Stereoselective Synthesis of 1,2‐Diols Employing a Practical Vanadium(II) Reagent. (1990)

Abstract A practical method of the stereoselective coupling of two different, yet electronically similar aldehydes, e.g. (I) and (II), (V) and (VI), employs the vanadium complex VTC yielding diastereomeric diols such as (III) + (IV), (VII) + (VIII).
Optimal Control of Sinusoidal Input Current Three Phase PWM Rectifiers. (1997)

A new design method based on the linear-quadratic control theory is developed for the control of PWM rectifiers with sinusoidal input current. The PWM rectifiers are promising because they can supply DC power while keeping a sinusoidal AC current with unity in the fundamental power factor. There are two types, a voltage-source rectifier and a current-source rectifier. The former is required to simultaneously control both the fundamental power factor and DC voltage, while the latter does so for both the fundamental power factor and DC current. State feedback control is essentially suited for multi-input and multi-output systems such as those. Here a discrete-time optimal regulator is applied to their control because it provides a microprocessor-based robust feedback system without steady-state errors in response to step reference and/or disturbance change. The regulator is implemented using a digital-signal-processor. Experimental results demonstrate the validity.
TRIDAC host computer functional specification (1983)

Definitive surgical resection of the primary tumor was a predictor of long-term survival after surgical resection for malignant nonfunctioning endocrine tumor.
Production of transgenic porcine blastocysts by nuclear transfer (2000)

In this study the in vitro development of porcine nuclear transfer (NT) embryos was investigated. Transgenic fetal fibroblast cells that were frozen after 5 days of serum starvation were injected immediately after thawing into enucleated metaphase II (MII) oocytes. Reconstructed embryos were activated by incubation in 200 microM thimerosal followed by a 30-min treatment of 8 mM DTT. The embryos were subsequently cultured in NCSU23, supplemented with 4 mg/ml BSA for 7 days. The actual cleavage rate (embryos showing > or =2 nuclei) in 6 replicates was 33% (ranging from 15% to 50%). Three blastocysts with cell numbers of 14, 15, and 18 were obtained. The blastocyst rate was significantly lower for NT embryos as opposed to parthenogenetically activated embryos (1% vs. 5%; P<0.05). The neomycin-resistance gene was amplified by PCR in all three NT embryos, indicating their origin from the injected transgenic fibroblasts. Efforts are now being directed in improvements in the nuclear transfer technology, whereby viable fetuses or offspring can be produced from these NT-embryos.
TheSaccharomyces cerevisiaeW303-K6001 cross-platform genome sequence: insights into ancestry and physiology of a laboratory mutt (2012)

Saccharomyces cerevisiae strain W303 is a widely used model organism. However, little is known about its genetic origins, as it was created in the 1970s from crossing yeast strains of uncertain genealogy. To obtain insights into its ancestry and physiology, we sequenced the genome of its variant W303-K6001, a yeast model of ageing research. The combination of two next-generation sequencing (NGS) technologies (Illumina and Roche/454 sequencing) yielded an 11.8 Mb genome assembly at an N50 contig length of 262 kb. Although sequencing was substantially more precise and sensitive than whole-genome tiling arrays, both NGS platforms produced a number of false positives. At a 378× average coverage, only 74 per cent of called differences to the S288c reference genome were confirmed by both techniques. The consensus W303-K6001 genome differs in 8133 positions from S288c, predicting altered amino acid sequence in 799 proteins, including factors of ageing and stress resistance. The W303-K6001 (85.4%) genome is virtually identical (less than equal to 0.5 variations per kb) to S288c, and thus originates in the same ancestor. Non-S288c regions distribute unequally over the genome, with chromosome XVI the most (99.6%) and chromosome XI the least (54.5%) S288c-like. Several of these clusters are shared with Σ 1278B, another widely used S288c-related model, indicating that these strains share a second ancestor. Thus, the W303-K6001 genome pictures details of complex genetic relationships between the model strains that date back to the early days of experimental yeast genetics. Moreover, this study underlines the necessity of combining multiple NGS and genome-assembling techniques for achieving accurate variant calling in genomic studies.
Association of Human‐Leukocyte‐Antigen Class I (B*0703) and Class II (DRB1*0301) Genotypes with Susceptibility and Resistance to the Development of Severe Acute Respiratory Syndrome (2004)

Severe acute respiratory syndrome (SARS) is a public health concern worldwide. By studying the human leukocyte antigen (HLA) types A, B, DR, and DQ alleles in 90 Chinese patients with serologically confirmed SARS infections, we identified a strong association between HLA-B*0703 (OR, 4.08; 95% CI, 2.03-8.18; P=.00072 [Bonferroni-corrected P value, P(c) <.0022]) and -DRB1*0301 (OR, 0.06; 95%, 0.01-0.47; P=.00008 [after Bonferroni correction, P<.0042]) and the development of SARS. Moreover, the frequency of B*0703 and B60 coinheritance (9.6%; 95% CI, 4.6%-19.0%) in our SARS group was significantly higher (P=3x10(-9)) than that expected in the general population (0.4%). These genetic data will critically affect both the study of the pathogenesis of SARS and the design of vaccination programs.
Osterix Regulates Calcification and Degradation of Chondrogenic Matrices through Matrix Metalloproteinase 13 (MMP13) Expression in Association with Transcription Factor Runx2 during Endochondral Ossification (2012)

Endochondral ossification is temporally and spatially regulated by several critical transcription factors, including Sox9, Runx2, and Runx3. Although the molecular mechanisms that control the late stages of endochondral ossification (e.g. calcification) are physiologically and pathologically important, these precise regulatory mechanisms remain unclear. Here, we demonstrate that Osterix is an essential transcription factor for endochondral ossification that functions downstream of Runx2. The global and conditional Osterix-deficient mice studied here exhibited a defect of cartilage-matrix ossification and matrix vesicle formation. Importantly, Osterix deficiencies caused the arrest of endochondral ossification at the hypertrophic stage. Microarray analysis revealed that matrix metallopeptidase 13 (MMP13) is an important target of Osterix. We also showed that there exists a physical interaction between Osterix and Runx2 and that these proteins function cooperatively to induce MMP13 during chondrocyte differentiation. Most interestingly, the introduction of MMP13 stimulated the calcification of matrices in Osterix-deficient mouse limb bud cells. Our results demonstrated that Osterix was essential to endochondral ossification and revealed that the physical and functional interaction between Osterix and Runx2 were necessary for the induction of MMP13 during endochondral ossification.
<title>Toward stable materials for electro-optic modulation and photorefractive applications: the hybrid organic-inorganic approach</title> (1999)

We have developed hybrid organic-inorganic materials based upon the incorporation of nonlinear chromophores in a rigid amorphous inorganic matrix. Functionalized thin films have been prepared using the sol-gel route allowing for mild synthesis conditions. Push-pull chromophores were either incorporated as guests or grafted on a silica based backbone via a spacer. Orientation of the dipolar chromophores within the materials was performed using the Corona technique. By playing on the structure of the push-pull chromophores and on its orientational stability inside the matrix, functionalized materials with large electro-optic coefficients and excellent stability have been designed. By combining both appropriate push-pull chromophores and photoconductors grafted on the matrix, materials showing interesting photorefractive properties can be obtained without requiring the application of an external electric field. Both the presence of a strong internal field in the poled materials and the occurrence of photo-assisted orientational birefringence plays a significant role.
ChemInform Abstract: Pd‐Catalyzed Deoxygenation of Mandelate Esters. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Dependability in Cyber-Physical Systems and Applications (2018)

editorial Free Access Share on Dependability in Cyber-Physical Systems and Applications Authors: Md Zakirul Alam Bhuiyan Fordham University, New York, NY, USA Fordham University, New York, NY, USAView Profile , Sy-yen Kuo National Taiwan University, Taipei, Taiwan National Taiwan University, Taipei, TaiwanView Profile , Damian Lyons Fordham University, New York, NY, USA Fordham University, New York, NY, USAView Profile , Zili Shao The Hong Kong Polytechnic University, Hung Hom, Hong Kong The Hong Kong Polytechnic University, Hung Hom, Hong KongView Profile Authors Info & Claims ACM Transactions on Cyber-Physical SystemsVolume 3Issue 1January 2019 Article No.: 1pp 1–4https://doi.org/10.1145/3271432Published:29 September 2018Publication History 4citation680DownloadsMetricsTotal Citations4Total Downloads680Last 12 Months116Last 6 weeks9 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteView all FormatsPDF
Observation of Bc+→D0K+ Decays (2017)

Using proton-proton collision data corresponding to an integrated luminosity of 3.0 fb^{-1}, recorded by the LHCb detector at center-of-mass energies of 7 and 8 TeV, the B_{c}^{+}→D^{0}K^{+} decay is observed with a statistical significance of 5.1 standard deviations. By normalizing to B^{+}→D[over ¯]^{0}π^{+} decays, a measurement of the branching fraction multiplied by the production rates for B_{c}^{+} relative to B^{+} mesons in the LHCb acceptance is obtained, R_{D^{0}K}=(f_{c}/f_{u})×B(B_{c}^{+}→D^{0}K^{+})=(9.3_{-2.5}^{+2.8}±0.6)×10^{-7}, where the first uncertainty is statistical and the second is systematic. This decay is expected to proceed predominantly through weak annihilation and penguin amplitudes, and is the first B_{c}^{+} decay of this nature to be observed.
Thermal Conduction Switch for Thermal Management of Chip Scale Atomic Clocks (IMECE2006-14540) (2008)

We report the first use of a bimetallic buckling disk as a thermal conduction switch. The disk is used to passively alter the thermal resistance of the package of a chip scale atomic clock. A vertical-cavity surface-emitting laser and a cesium vapor cell, contained in the clock, must be maintained at 70±0.1°C even under an ambient temperature variation of −40°Cto50°C. A thermal test vehicle has been developed to characterize a sample package with a thermal conduction switch. Three cases are presented for the temperature control of the test vehicle under different load placements and environmental conditions: (1) a heating load with a good conduction path to the switch in a vacuum package; (2) the same loading as in Case 1, but packaged in air; and (3) a heating load insulated from the switch, in a vacuum package. At 38°C, the switch snaps upward to reduce the package’s thermal resistance. As a result, the heating power needed to maintain a constant temperature, 63.9±0.1°C, is increased from 118to200mW for Case 1. Such a significant change of the thermal resistance demonstrates the effectiveness of the thermal switch. However, the switch becomes less effective with air filling the gap, as in Case 2, and the switch is not effective at all if the heating load does not have a good conduction path to the switch as in Case 3. The steady state response of this novel thermal conduction switch has been well characterized through experimentation and finite element analysis.
Supplementary Table 1 from Robust Antitumor Immunity in a Patient with Metastatic Colorectal Cancer Treated with Cytotoxic Regimens (2023)

&lt;p&gt;Supplementary Table 1&lt;/p&gt;
Modeling the efficiency of Förster resonant energy transfer from energy relay dyes in dye-sensitized solar cells (2010)

Förster resonant energy transfer can improve the spectral breadth, absorption and energy conversion efficiency of dye sensitized solar cells. In this design, unattached relay dyes absorb the high energy photons and transfer the excitation to sensitizing dye molecules by Förster resonant energy transfer. We use an analytic theory to calculate the excitation transfer efficiency from the relay dye to the sensitizing dye accounting for dynamic quenching and relay dye diffusion. We present calculations for pores of cylindrical and spherical geometry and examine the effects of the Förster radius, the pore size, sensitizing dye surface concentration, collisional quenching rate, and relay dye lifetime. We find that the excitation transfer efficiency can easily exceed 90% for appropriately chosen dyes and propose two different strategies for selecting dyes to achieve record power conversion efficiencies.
Targeting Efficacy of Simvastatin for Hormone-Dependent Carcinomas through Solid Lipid Nanoparticles (2016)

Folate conjugated Simvastatin loaded Solid lipid nanoparticles (SIM-SLNs) were constructed after the preformulation studies such as Differential calorie metry (DSC), Fourier transform infrared spectroscopy (FTIR) and partition coefficient studies. SIM-SLNs were evaluated in terms of particles size, zeta potential, drug encapsulation, and drug release. The cytotoxicity of the SLNs was evaluated on MCF-7 Human Breast Carcinoma cells (MCF-7 cells) by MTT assay. In vivo pharmacokinetic parameters and Bio-distribution were observed in Wistar rats. The particle size of SIM-SLNs (F6) was 177.4 nm with a zeta potential of -5.16 mV. The entrapment efficiency and drug loading was found to be higher in SIM-SLNs. SLN formulation released the drug in sustained manner over a period of 24 hours. Various kinetic models were fitted and it was observed that Higuchi’s model was the best fit model. SIM-SLNs showed highest cytotoxicity in tumor cells in vitro. In vivo studies showed that there is significant increase in the pharmacokinetic parameters and Bio-distribution of SIM-SLNs when compared to the pure drug suspension. Higher relative bioavailability would be due to avoidance of first-pass hepatic metabolism by intestinal lymphatic transport, which circumvents the liver. According to these results, the novel SIM-SLNs provided sustained release of the drug, and these systems are the preferred drug carriers for lipophilic drugs to overcome the oral bioavailability problem of drug and to increase targeting efficacy to the specific organs as breast, prostate and ovary.
Morphometry and densitometry of alveolar macrophage cytoplasmic particles in Chernobyl, Ukraine, liquidators. (1997)

Processing of digitized ultrastructural images of AMs provides accurate morphometric data that can be used further for clinical purposes, in particular to evaluate BAL performed either for diagnosis or treatment.
LESSONS FROM STANDARD CHARM DECAYS (2004)

Recent charm results are reviwed with special attention to spectroscopy and hadronic decays. Two new states decaying to [Formula: see text] and [Formula: see text] were recently discovered by BaBar and CLEO. In the baryon sector, the first observation of a doubly charmed baryon was announced by SELEX. Several amplitude analysis on charm hadronic decays are also discussed.
Feature Engineering for Data Streams (2018)

This chapter provides an overview of streaming feature engineering. It focuses on the steps of feature construction and selection of feature engineering. The chapter summarizes the typical streaming settings and their corresponding formal definitions. It reviews automated feature construction algorithms including linear and non-linear methods. The chapter provides an overview of feature selection algorithms with different streaming settings. It discusses some open questions and possible research directions of feature engineering for data streams. The chapter considers the setting of streaming instances with fixed features and the setting of streaming features with fixed instances. Principal Component Analysis, aiming to maximally preserve the data variance, has been widely used in many real-world applications such as dimension reduction, signal denoising, and correlation analysis. Linear discriminant analysis is powerful for supervised dimensionality reduction and has been applied successfully to many applications, including machine learning, data mining, and bioinformatics.
Quantifying Physical Activity Levels and Sleep in Hemodialysis Patients Using a Commercially Available Activity Tracker (2016)

Interventions to increase physical activity on Sundays could improve physical activity levels overall. Prospective studies are necessary to further explore the use of tracking devices to identify patients at risk and to implement targeted interventions.
Characterization of Pt–Sn/Sio2catalysts and the role of Sn in NO–hydrocarbon reactions (1996)

Pt–Sn/SiO2 catalysts prepared by selective chemical vapour deposition of Sn(CH3)4 to Pt particles supported on SiO2 have been characterized by extended X-ray absorption fine structure (EXAFS) at both Sn K-edge and Pt LIII-edge, FTIR, transmission electron microscopy (TEM), and H2 and CO adsorption measurements. Sn atoms were suggested to be located at the first layer of the bimetallic particles until Sn/Pt = 0.26, giving an Sn—Pt bond length of 0.263 nm and Sn—Sn bond length of 0.260 nm. A model structure of the Pt–Sn bimetallic layers was proposed. The Pt–Sn/SiO2 catalyst was remarkably active for NO dissociation, leaving deposited oxygen atoms at the surface. The deposited oxygen atoms were bonded to the Sn atoms to give Sn—O bonds of length 0.198 nm, which were active for hydrocarbon oxidation reactions. The reactivity of the SnOx layer was suggested to be promoted by the presence of Pt atoms. The catalytic NO–C3H8 and NO–CH4 reactions proceeded via NO dissociation and successive oxidation of hydrocarbons on Pt–Sn/SiO2. The reaction rate and selectivity varied with the Sn/Pt ratio. Sn addition increased the N2 selectivity from 50% for Pt/SiO2 to 100% for Pt–Sn/SiO2. N2 selectivity was related mainly to the oxygen deficiency in the SnOx layers.
Chest computed tomography: a validated surrogate endpoint of cystic fibrosis lung disease? (2012)

Clinical trials for the treatment of cystic fibrosis (CF) lung disease are important to test and optimise new therapeutic interventions. To evaluate the effect of these interventions, sensitive and accurate outcome measures are needed. The most commonly used endpoints are spirometric variables such as the forced expiratory volume in 1 s and respiratory tract exacerbations. Unfortunately, these endpoints are relatively insensitive for monitoring progression of CF lung disease, and thus require a large number of patients when used in clinical studies. In addition, these endpoints are not suitable to study CF lung disease in young children. Chest computed tomography (CT) holds great promise for use as a sensitive surrogate endpoint in CF. A large body of evidence has been produced to validate the use of chest CT as a primary endpoint to study CF lung disease. However, before chest CT can be used in clinical trials, it has to be recognised as a validated surrogate endpoint by regulatory agencies. The aim of this review is to summarise what is currently known about the use of chest CT as surrogate endpoint in clinical trials in CF.