gebhart/patrepeval huggingface dataset:
HPLC Method for Monitoring the Conjugated Dienes and Olefins in FCC, Coker Gasolines, and their Hydrogenated Products (2014)

The conjugated dienes if present in gasoline have the tendency to polymerize and cause fouling during various refinery processes. Therefore the conjugated dienes need to be reduced. While the conjugated dienes in gasoline are undesirable, the olefins are desirable and act as octane booster. The selective hydrogenation unit selectively reduces conjugated dienes keeping the content of olefins more or less intact. A method based on HPLC-UV-RI has been reported to simultaneously monitor the conjugated dienes and olefins content in the gasoline range samples. The reported method has the detection level of 0.02 (w/W)% for the total conjugated dienes with respect to 2,4-dimethyl 1,3-pentadiene (DMP). The calibration curve for DMP is drawn in the range 0.2–2.5% (w/W) and the R2 is found to be 0.9972. The method is also applicable for the estimation of olefins content above 10% (w/W) level with respect to 1-octene. The calibration curve is drawn in the range 10–50% (w/W) of 1-octene and the R2 is found to be 0.9995.
Stable glow discharge for synthesis of carbon nanotubes (1995)

The use of a stable glow discharge for the synthesis of carbon nanotubes is reported. Bundles of buckytubes are synthesized with remarkably large diameters (up to 200 μm). The bundles are evenly spaced, parallel, and occupy the entire central region of the deposited rod. High resolution electron microscopy (HREM) images of the deposited rod produced by the glow discharge revealed higher yield and improved quality buckytubes as compared to those produced by an arc discharge. The behavior of the two deposition modes (glow and arc) has been compared and their effects on the formation of buckytubes are discussed.
Simultaneously covalent and ionic bridging towards antifouling of GO-imbedded nanocomposite hollow fiber membranes (2015)

GO-imbedded nanocomposite hollow fiber membranes were investigated for oily water treatment, with the aim to improve GO-polymer interfacial interaction and membrane anti-fouling properties <italic>via</italic> the formation of a simultaneously covalent and ionic inter-network.
Simultaneous PSI-Based Orthognathic and PEEK Bone Augmentation Surgery Leads to Improved Symmetric Facial Appearance in Craniofacial Malformations (2022)

(1) The aim of the present study was to compare the outcome of facial symmetry after simultaneous digitally planned patient-specific implant (PSI-) based orthognathic surgery and polyether ether ketone (PEEK) bone augmentation in patients with craniofacial malformations. (2) To evaluate the outcome of the two different surgical approaches (conventional PSI-based orthognathic surgery versus simultaneous PSI-based orthognathic surgery with PEEK bone augmentation), a comparison of five different groups with a combination of the parameters (A) with vs. without laterognathia, (B) syndromic vs. non-syndromic, and (C) surgery with vs. without PEEK bone augmentation was conducted. The digital workflow comprised cone beam CT (CBCT) scans and virtual surgery planning for all patients in order to produce patient specific cutting guides and osteosynthesis plates. Additionally, deformed skulls were superimposed by a non-deformed skull and/or the healthy side was mirrored to produce PSI PEEK implants for augmentation. Retrospective analyses included posterior-anterior conventional radiographs as well as en face photographs taken before and nine months after surgery. (3) Simultaneous orthognathic surgery with PEEK bone augmentation significantly improves facial symmetry compared to conventional orthognathic surgery (6.5%P (3.2-9.8%P) (<i>p</i> = 0.001). (4) PSI-based orthognathic surgery led to improved horizontal bone alignment in all patients. Simultaneous PEEK bone augmentation enhanced facial symmetry even in patients with syndrome-related underdevelopment of both soft and hard tissues.
4.1 A 640×480 dynamic vision sensor with a 9µm pixel and 300Meps address-event representation (2017)

We report a VGA dynamic vision sensor (DVS) with a 9µm pixel, developed through a digital as well as an analog implementation. DVS systems in the literature try to increase spatial resolution up to QVGA [1–2] and data rates up to 50 million events per second (Meps) (self-acknowledged) [3], but they are still inadequate for high-performance applications such as gesture recognition, drones, automotive, etc. Moreover, the smallest reported pixel of 18.5µm is too large for economical mass production [3]. This paper reports a 640×480 VGA-resolution DVS system with a 9µm pixel pitch supporting a data rate of 300Meps for sufficient event transfer in spite of higher resolution. Maintaining acceptable pixel performance, the pixel circuitry is carefully designed and optimized using a BSI CIS process. To acquire data (i.e., pixel events) at high speed even with high resolution (e.g., VGA), a fully synthesized word-serial group address-event representation (G-AER) is implemented, which handles massive events in parallel by binding neighboring 8 pixels into a group. In addition, a 10b programmable bias generator dedicated to a DVS system provides easy controllability of pixel biases and event thresholds.
Differential effect of high doses versus low doses of interleukin-12 on the adoptive transfer of human specific cytotoxic T lymphocyte in autologous lung tumors engrafted into severe combined immunodeficiency disease-nonobese diabetic mice (2001)

BACKGROUND Interleukin (IL)-12 can enhance the development of effective immune responses against tumors as well as against certain infectious agents. It is therefore a potential candidate for therapeutic use in cancer therapy and in design of vaccines against several infectious diseases. METHODS The authors have established a specific cytotoxic T-cell line (TIL-Heu) from lymphocytes infiltrating a human large cell carcinoma of the lung (LCC). In the current report, the authors have investigated the in vivo effect of recombinant human IL-12 (rhIL-12) on the adoptive transfer of TIL-Heu cells in autologous tumor (Heu-n) engrafted into severe combined immunodeficiency disease–nonobese diabetic (SCID-NOD) mice. RESULTS Initial in vitro experiments indicated that rhIL-12 increased the cytotoxic potential of TIL-Heu cells in a dose-dependent manner. Heu-n tumors transplanted into SCID-NOD mice were injected with TIL-Heu cells, resulting in a significant tumor growth inhibition. When low doses of rhIL-12 were injected intratumorally after TIL-Heu transfer, a clear increase in tumor growth suppression was observed. Surprisingly, higher doses of rhIL-12 had no effect on cytotoxic T lymphocyte (CTL)–induced prevention of tumor growth. Further in vitro experiments revealed an inhibition of tumor cell lysis after incubation with supernatant of TIL-Heu cells stimulated with high doses of rhIL-12, strongly suggesting that an immunosuppressive factor secreted by the high dose IL-12–stimulated CTL may be responsible for the tumor escape observed in vivo. CONCLUSIONS The authors' data indicate that IL-10 may play a critical role in the lack of effect of high dose IL-12, by mediating tumor cell resistance to CTL killing. Therefore, understanding the cross-talk between immunoregulatory and immunosuppressive cytokines ultimately may provide new approaches to improve cytokine-mediated cancer immunotherapy. Cancer 2001;91:113–22. © 2001 American Cancer Society.
Fractional repetition codes with flexible repair from combinatorial designs (2014)

Fractional repetition (FR) codes are a class of regenerating codes for distributed storage systems with an exact (table-based) repair process that is also uncoded, i.e., upon failure, a node is regenerated by simply downloading packets from the surviving nodes. In our work, we present constructions of FR codes based on Steiner systems and resolvable combinatorial designs such as affine geometries, Hadamard designs and mutually orthogonal Latin squares. The failure resilience of our codes can be varied in a simple manner. We construct codes with normalized repair bandwidth ($β$) strictly larger than one; these cannot be obtained trivially from codes with $β= 1$. Furthermore, we present the Kronecker product technique for generating new codes from existing ones and elaborate on their properties. FR codes with locality are those where the repair degree is smaller than the number of nodes contacted for reconstructing the stored file. For these codes we establish a tradeoff between the local repair property and failure resilience and construct codes that meet this tradeoff. Much of prior work only provided lower bounds on the FR code rate. In our work, for most of our constructions we determine the code rate for certain parameter ranges.
RECOGNITION OF SYMBIOTIC ALGAE BYHYDRA VIRIDIS.A QUANTITATIVE STUDY OF THE UPTAKE OF LIVING ALGAE BY APOSYMBIOTICH. VIRIDIS (1973)

1. An individual Hydra viridis (Florida Strain) harbors approximately 1.5 x 105 unicellular green algae. These algae are normally found in the basal portion of gastrodermal digestive cells. An average of approximately 18 algae per digestive cell is encountered in the central region (stomach and budding zone) of the hydra under a given set of maintenance conditions.2. The average number of algae per digestive cell may range from 7 to 22 depending on feeding schedules and photoperiod under which hydra cultures are maintained.3. The symbiosis can be synthesized artifically by injecting symbiotic algae from H. viridis into the coelenteron of aposymbiotic H. viridis. Within 15 minutes after injection the algae are taken up by the digestive cells, apparently by phagocytosis. During the next hour, the algae move from the site of uptake to the basal part of the digestive cell.4. Both green and aposymbiotic H. viridis can take up only about 8 ± 2 algae from an injected suspension of cells. Uptake may be limited by the extent to which the cell can sustain phagocytosis, rather than by availability of intracellular space. In aposymbiotic H. viridis, the full complement of 18 algae is attained by algal cell division and requires about 18 days.5. An assortment of free-living and symbiotic algae were injected into H. viridis aposymbionts. All were rejected immediately with the exception of hydra algae and a symbiotic alga from Paramecium (NC64A) which formed a stable hereditary endosymbiosis with H. viridis. Growth rates of these hydra were virtually identical with those of normal green hydra.6. The acquisition of algae by hydra digestive cells appears to involve several "phases" including contact , recognition, phagocytosis, and intracellular transport.
MEASUREMENTS AND NUMERICAL PREDICTION OF FLOW AND PARTICLE FIELDS IN TURBULENT PARTICLE-LADEN FLOWS -TURBULENCE MODULATION (2001)

The objective of the present study is to analyze the influence of solid particles dispersed in a fluid on the fluid itself. This phenomenon, known as turbulence modulation, is investigated here by experimental as well as numerical methods. The study is restricted to the investigation of the respective turbulent properties. Experiments are performed in a specially designed vertical closed-circuit wind-tunnel. Air is used as continuous phase and solid non-reacting mono-dispersed particles of various diameters in the range from 120 to 480 µm act as dispersed phase. Phase-Doppler Anemometry (PDA) is used to measure fluid and particle velocities, respectively. In order to gain preliminary information in predicting the physical features of modulation with existing models, numerical simulations are performed in a first step using the k-ε model for turbulent flows, modified to allow for Euler-Lagrange gas-particle flow analysis. Experimental and numerical results are compared to each other. The results display very clearly the influence of the particle concentration and diameter. Parameters for generation and attenuation of continuous phase turbulence are identified.
Glutathione Transferases as Targets for Cancer Therapy (2009)

Besides catalyzing the inactivation of various electrophile-producing anticancer agents via conjugation to the tripeptide glutathione, some cytosolic proteins belonging to the glutathione transferase (formerly glutatione-S-transferase; GST) superfamily are emerging as negative modulators of stress/drug-induced cell apoptosis through the interaction with specific signaling kinases. In addition, several data link the overexpression of some GSTs, in particular GSTP1-1, to both natural and acquired resistance to various structurally unrelated anticancer drugs. Tumor overexpression of these proteins has provided a rationale for the search of GST inhibitors and GST-activated cytotoxic prodrugs. In the present review we discuss the current structural and pharmacological knowledge of both types of GST-targeting compounds.
The current landscape of nucleic acid therapeutics (2021)

The increasing number of approved nucleic acid therapeutics demonstrates the potential to treat diseases by targeting their genetic blueprints in vivo. Conventional treatments generally induce therapeutic effects that are transient because they target proteins rather than underlying causes. In contrast, nucleic acid therapeutics can achieve long-lasting or even curative effects via gene inhibition, addition, replacement or editing. Their clinical translation, however, depends on delivery technologies that improve stability, facilitate internalization and increase target affinity. Here, we review four platform technologies that have enabled the clinical translation of nucleic acid therapeutics: antisense oligonucleotides, ligand-modified small interfering RNA conjugates, lipid nanoparticles and adeno-associated virus vectors. For each platform, we discuss the current state-of-the-art clinical approaches, explain the rationale behind its development, highlight technological aspects that facilitated clinical translation and provide an example of a clinically relevant genetic drug. In addition, we discuss how these technologies enable the development of cutting-edge genetic drugs, such as tissue-specific nucleic acid bioconjugates, messenger RNA and gene-editing therapeutics.
Comparative Study on Dry Etching of α- and β-SiC Nano-Pillars (2013)

A comprehensive study on different polytypes (α-SiC and β-SiC) and crystal orientations ((0001) and (11-20) of 6H-SiC) has been investigated in order to elaborate Silicon carbide (SiC) nanopillar using inductively coupled plasma etching method. The SiC nanopillars with the cross section of rhombus, pentagon, and hexagonal have been obtained on β-SiC (001), misoriented α-SiC (11-20), and α-SiC (0001) on-axis substrates, respectively. It was found that crystal orientations and polytypes play key roles for the morphology of SiC nanopillars, which reflects the so-called Wulff's rule.
Research on the function of single jersey based on the 3D channel structure (2023)

The main purpose of this experimental study is to determine the thermal properties and the moisture conduction function of a single jersey with a three-dimensional channel structure. As the channel structure of single jersey is gradually applied in the functional sportswear sector, the channel structure has been knitted by single jacquard technology for research purposes. Firstly, the formation principle and the structural unit of knitted fabric with the channel structure were explained. Then, the effects of channel structure with different sizes on thermal insulation, quick-drying, wicking height, and moisture management performance of the fabrics were investigated. Finally, the performance characteristics of the channel structure fabric were analyzed through the channel structure model. The analysis obtains that the channel structure of the sample holds more stagnant air and a large evaporation area. Moreover, as the courses or wales of structural units increase, the thermal insulation rate and the evaporation rate of the fabric improve accordingly. Also, it has a superior effect on the improvement of the wicking effect and the unidirectional transmission of the fabrics. However, when the structural unit exceeds a particular value, the fabric structure begins to deform, which makes its wicking height and unidirectional transmission properties decline. It provides a reference for the design and development of the 3D channel structure of the functional knitted fabric.
Across the Board: Antonio Facchetti (2018)

In this series of articles, the board members of ChemSusChem discuss recent research articles that they consider of exceptional quality and importance for sustainability. This entry features Prof. Dr. Antonio Facchetti, who discusses the use of organic photovoltaic (OPV) devices as a source of renewable energy, and challenges that must be met for OPVs to serve as a viable fully sustainable technology for future energy production, taking into account the components used in such devices and their stability and durability.
Classification of the micromorphology of breast calcifications in x-ray dark-field mammography (2017)

The distant goal of this investigation is to reduce the number of invasive procedures associated with breast micro calcification biopsies, by improving and refining conventional BIRADS micro calcification assessments with x-ray dark-field mammography. The study was institutional review board (IRB) approved. A dedicated grating-based radiography setup (Mo-target, 40 keV, 70 mA) was used to investigate one breast mastectomy and 31 biopsies with dark-field mammography. Comparing the absorption and scattering properties of micro calcifications clusters enables accessing information on the interior morphology on the micron-scale retrieved in a non-invasive manner. Insights underlying the micro morphological nature of breast calcifications were verified by comprehensive high-resolution micro-CT measurements. It was found that Dark-field mammography allows a micro-structural classification of breast micro calcification as ultra-fine, fine, pleomorphic and coarse textured using conventional detectors. Dark-field mammography is thereby highly sensitive to minor structural deviations. Finally, the determined micro-texture of the investigated micro calcifications was correlated with findings obtained from histopathological work up. The presented results demonstrate that dark-field mammography yields the potential to enhance diagnostic validity of current micro calcification analysis - which is yet limited to the exterior appearance of micro calcification clusters - and thereby reduce the number of invasive procedures.
Heteroleptic platinum(ii) complexes of 8-quinolinolates bearing electron withdrawing groups in 5-position (2008)

A series of novel luminescent platinum(II) complexes bearing orthometalated 2-phenylpyridine ligands (C N), namely 2-phenylpyridine (4) and 3-hexyloxy-2-phenylpyridine (5), and several 5-substituted quinolinolate ligands (5-X-Q), where X = NO2 (a), X = CHO (b), X = Cl (bearing another Cl in 7-position of the Q-ligand) (c) and X = H (d) have been synthesized, characterized and their photophysical properties were studied. All complexes were obtained as a single isomer with N atoms of the C N and Q ligands trans-coordinated to the platinum center as evidenced using single-crystal X-ray crystallography and NMR spectroscopy. Absorbance, luminescence as well as lifetime measurements in solution and in the solid state have been performed to establish a qualitative relationship between structure and luminescence properties. The compounds under investigation absorb intensively via an intraligand charge transfer (ILCT) in the visible range (460-480 nm) and emit from fluid solution and in the solid state at room temperature at 600-630 nm. The complexes show quantum yields up to 25% and lifetimes in the range of 20-30 micros in deoxygenated organic solvents at room temperature. The emitting state can be best described as a triplet intraligand charge-transfer state localized mainly on the quinolinolate ligand. In these complexes the phenylpyridine ligand can be essentially regarded as an ancillary ligand. Density functional theory (DFT) calculations were carried out on both the ground (singlet) and excited (triplet) states of these complexes and revealed the influence of the substitution of the quinolinolate ligand on the HOMO/LUMO energies and the oscillator strengths. Substitution on 3-position of the phenylpyridine ligand does not impact on the transition energies, and is thus suited to introduce other functional moieties, such as a solubilizing hexyloxy group.
Precision interferometry for measuring wavefronts of multi-wavelength optical pickups (2008)

A novel wavefront measurement interferometer is developed that enables the user to evaluate the wavefronts of multi-wavelength optical pickups. In this interferometer, instead of transparent pinholes used in Mach-Zehnder interferometers, reflection dot pinhole mirrors are used to generate reference wavefronts for different wavelengths which make the optical system very flexible and simple compared with those using transparent pinholes. The interferometer is designed to operate at wavelengths of 405 nm, 650 nm and 780 nm over an NA range of up to 0.95, which is very difficult to realize when transparent pinholes are used for generating reference wavefronts. The three-beam problem is solved and the optics of the interferometer is simplified by employing a software filter instead of using spatial filters in the optics of the interferometer. The instrument has an equal optical path length that enables the user to measure pickups with a very short coherence length. A new method by which asymmetric aberration components, such as astigmatic and coma aberrations, can be calibrated by rotating the measured lens with 90 and 180 degrees is proposed and the calibration results are verified by using a high precision reference point source. System accuracy is also evaluated by comparing with the measurement results obtained by commercial Fizeau type interferometer and a good agreement is achieved.
A New Lamination and doping Concepts for Enhanced Li – S Battery Performance (2017)

Lithium ion batteries (LIBs) clearly dominated the area of high-energy storage systems for the past decade with significant research and development activity focused on the development of cathode and anode materials to maximize the specific energy storage, stability, and cycle life of the batteries. However, with the increasing demand in the EV industry for low cost, low weight, and high-energy storage batteries to meet the EV everywhere grand challenge, the current focus of research has shifted towards the development of lithium sulfur batteries (LSB) owing to the high theoretical specific capacity exhibited by sulfur compared to other cathode materials currently available. Li–S battery shows a theoretical capacity of 1675 mAh/g corresponding to the formation of Li2S which makes sulfur a promising electrode to replace the layered transition metal oxides (~150 mAh/g) and LiFePO4 (~170 mAh/g) hitherto deployed in present LIB systems. Moreover, the abundance of sulfur in the earth’s crust makes it a more economical and highly attractive proposition compared to currently existing cathodes. Despite advantages of sulfur, the existing Li-S battery technology display poor cyclability, low coulombic efficiency (CE) and very low cycle life due to the following issues: 1. Polysulfide (PS) dissolution; 2. Sluggish kinetics of PS to Li2S conversion; 3. High PS diffusivity in the electrolyte; 4. Insulating nature or poor conductivity of sulfur/Li2S; 5. Volumetric expansion/contraction of sulfur; 6. Shuttling of PS along with Li+. These issues result in loss of sulfur causing mechanical disintegration, surface passivation of both anode and cathode, thereby decreasing the specific capacity and columbic efficiency (CE). Present generation sulfur cathodes also show low specific storage capacity, very poor charging rates and low loading densities. Research is needed to overcome the issues impeding Li-S battery technology development.