gebhart/patrepeval huggingface dataset:
22 kV, 1 cm2, 4H-SiC n-IGBTs with improved conductivity modulation (2014)

In this paper, we report our recently developed large area 4H-SiC n-IGBTs that have a chip size of 1 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and an active conducting area of 0.37 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . A blocking voltage of 22.6 kV has been demonstrated with a leakage current of 9 μA at a gate bias of 0 V at room-temperature. This is the highest breakdown voltage of a single MOS-controlled semiconductor switch reported to date. To improve the conductivity modulation and lower the conduction losses during the on-state, a thermal oxidation process was applied to enhance the carrier lifetime prior to the device fabrication. Compared to the devices that did not receive this lifetime enhancement process, the lifetime enhanced devices displayed nearly 1 V lower forward voltage drop with little increase in switching energy and no degradation of static blocking characteristics. A specific differential on-resistance of 55 mΩ-cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> at 20 A and 125 °C was achieved, suggesting that bipolar power devices with thick drift regions can benefit from further enhancement of the ambipolar carrier lifetime.
Supplementary Figure 2 from The Putative Tumor Suppressor microRNA-101 Modulates the Cancer Epigenome by Repressing the Polycomb Group Protein EZH2 (2023)

Supplementary Figure 2 from The Putative Tumor Suppressor microRNA-101 Modulates the Cancer Epigenome by Repressing the Polycomb Group Protein EZH2
Controlled release of bioactive recombinant human growth hormone from PLGA microparticles (2010)

Controlled release formulation of recombinant human growth hormone (r-hGH) was achieved using poly lactide-co-glycolide (PLGA) polymer. Denaturation of r-hGH by dichloromethane during primary emulsification step of particle preparation was minimized by using human serum albumin whereas inclusion of sucrose and sodium bicarbonate helped in reducing protein denaturation during lyophilization and polymer particle degradation. Encapsulation efficiency of r-hGH entrapped in PLGA particles (size approximately 30 microm) was around 45% with protein load 20 microg of r-hGH/mg of polymer particles. Porous particles showed quick release of r-hGH in comparison to non-porous particles in vitro. More than 10 ng/mL of bioactive r-hGH was found in the serum of the experimental animals observed for a 30-day period after a single intramuscular injection of the polymeric formulation. Incorporation of optimal stabilizers is thus essential for the development of a stable, month long controlled release of polymer particle based r-hGH formulation.
Iron-repressible Outer-membrane Proteins of Pasteurella haemolytica (1989)

The outer-membrane protein (OMP) profile of Pasteurella haemolytica grown under iron-replete and iron-restricted conditions was studied by polyacrylamide gel electrophoresis and immunoblotting. A serotype 1 isolate induced the synthesis of a new 77,000 Mr OMP in iron-restricted media while two other proteins of 100,000 Mr and 71,000 Mr were synthesized in increased amounts. None of these proteins were peptidoglycan-associated or heat-modifiable, and only the 100,000 Mr protein showed some degree of disulphide cross-linking. Kinetic analysis revealed that the iron-repressible proteins appeared in the outer membrane within 15 min of establishment of iron-restricted conditions. Analysis of P. haemolytica isolates representing serotypes 1 to 12 showed that iron-repressible OMPs of 77,000 Mr and 71,000 Mr could be induced in all 12 serotypes but that there was some variability in the expression of the 100,000 Mr protein. Immunoblotting of OMPs with convalescent sera from P. haemolytica-infected calves indicated that antibodies directed against all three iron-repressible OMPs were present, suggesting that these proteins were expressed in vivo.
Synthesis and Reactivity of [(silox)2MoNR]2Hg (R = tBu, tAmyl; silox = OSitBu3):  Unusual Thermal Stability and Ready Nucleophilic Cleavage Rationalized by Electronic Factors (2007)

Treatment of (DME)Cl2Mo(=NR)2 (R=tBu, (1-tBu), tAmyl (1-tAmyl)) with 2 equiv of tBu3SiOH (siloxH) and 1 equiv of HCl produced (silox)2Cl2Mo=NR (R=tBu, (3-tBu), tAmyl (3-tAmyl)); subsequent reduction by Na/Hg afforded the Mo(V) chloride, (silox)2ClMo=NtBu (4-tBu), and the Mo(IV) mercury derivatives, [(silox)2Mo=NR]2Hg (R=tBu ((5-tBu)2Hg), tAmyl ((5-tAmyl)2Hg)). Reductions of 3-tBu and 3-tAmyl in the presence of L (L=PMe3, pyridine, 4-picoline) led to the isolation of adducts (silox)2(Me3P)Mo=NR (R=tBu (6-tBu), tAmyl (6-tAmyl)) and (silox)2L2Mo=NtBu (L=py (7-py), 4-pic (7-4-pic)). Single-crystal X-ray structural investigations of pseudo-tetrahedral 4-tBu, Hg-capped, pseudo-trigonal planar (5-tBu)2Hg, pseudo-tetrahedral 6-tBu, and trigonal bipyramidal 7-4-pic reveal that all possess a closed O-Mo-O angle when compared to the N=Mo-O angles. A molecular orbital rationale and supporting calculations suggest that this is a manifestation of the greater pi-donating ability of the imido relative to that of the siloxides. While the D(Mo-Hg) of [(HO)2Mo=NH]2Hg ((5')2Hg) was calculated to be 22.4 kcal/mol, (5-R)2Hg (R=tBu, tAmyl) are remarkably stable; (5-tBu)2Hg degraded in a first-order fashion with DeltaG=31.9(1) kcal/mol. In the presence of strong (L=PMe, pyridine, S8) or weak (L=2-butyne, ethylene, N2O, 1,4,7,10-tetrathiacyclododecane, 1,4,7,10,13,16-hexathiacyclooctadecane) nucleophiles, an enhanced rate of Mo-Hg bond cleavage was noted, with some of the former group generating adducts in <5 min; the products were 6-tBu, 7-py, (silox)2(S)Mo=NtBu (10-tBu), (silox)2Mo=NtBu(C2Me2) (8-tBu), (silox)2(C2H4)Mo=NtBu (11-tBu), (silox)2(O)Mo=NtBu (9-tBu), and a mixture of 10-tBu and 11-tBu, respectively. Some of these were independently prepared via substitution of 6-tBu. According to calculations and a molecular orbital rationale, dissociation of the Mo-Hg bond in (5-R)2Hg (R=tBu, tAmyl) is orbitally forbidden, and the addition of a nucleophile to the terminus of the Mo-Hg-Mo linkage mitigates the symmetry requirements. The mechanism of thermal degradation was studied with mixed success. NMR spectroscopy revealed imido exchange between (5-tBu)2Hg and (5-tAmyl)2Hg during an initial induction period and a subsequent rapid exchange period that implicated free 5-R (R=tBu, tAmyl). Further crossover studies revealed siloxide exchange as an additional complication.
The Beltrami geometrical framework of color image processing (1999)

The Beltrami geometrical framework for scale-space flows is generalized to nontrivial color space geometries and implemented in analysis and processing of color images. We demonstrate how various models of color perception, interpreted as geometries of the color space, result in different enhanced processing schemes.
Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution (2015)

Somatic L1 retrotransposition events have been shown to occur in epithelial cancers. Here, we attempted to determine how early somatic L1 insertions occurred during the development of gastrointestinal (GI) cancers. Using L1-targeted resequencing (L1-seq), we studied different stages of four colorectal cancers arising from colonic polyps, seven pancreatic carcinomas, as well as seven gastric cancers. Surprisingly, we found somatic L1 insertions not only in all cancer types and metastases but also in colonic adenomas, well-known cancer precursors. Some insertions were also present in low quantities in normal GI tissues, occasionally caught in the act of being clonally fixed in the adjacent tumors. Insertions in adenomas and cancers numbered in the hundreds, and many were present in multiple tumor sections, implying clonal distribution. Our results demonstrate that extensive somatic insertional mutagenesis occurs very early during the development of GI tumors, probably before dysplastic growth.
Improved Monodispersity of Plasmonic Nanoantennas via Centrifugal Processing (2011)

Noble metal nanoparticle clusters underlie a variety of plasmonic devices and measurements including surface-enhanced Raman spectroscopy (SERS). Because of the strong dependence of plasmonic properties on nanoparticle cluster aggregation state, the elimination of non-SERS-active structures and the refinement of the nanoparticle cluster population are critical to realizing uniform and reproducible structures for plasmonic nanoantenna applications such as SERS-based sensors. In this Letter, we report a centrifugal sorting technique for gold core/silica shell nanoparticles that host SERS reporter molecules at the gold/silica interface. The relatively massive nanoparticle clusters are sorted by sedimentation coefficient via centrifugation in a high-viscosity density gradient medium, iodixanol, which yields solutions that contain a preponderance of one aggregation state and a diminished monomer population, as determined by transmission electron microscopy, extinction spectroscopy, and SERS. A quantitative analysis of the nanoparticle sedimentation coefficients is presented, thus allowing this approach to be predictably generalized to other nanoparticle systems.
Synthesis and partial characterization of (silica)rhodium dihydrides: a new catalyst for olefin hydrogenation (1980)

The synthesis, characterization, and catalytic activity toward olefin hydrogenation of (silica)rhodium dihydrides is described.
Engineered Heart Valve Tissue Formation at the Organ Level: Effects of Flow Dynamics on Tissue Development (2008)

Tissue engineered heart valve (TEHV) development protocols have yet to be optimized to an extent that can offer long-term function of value to patients, beyond contemporary clinical practices. One method of optimization may be possible through appropriate mechanical conditioning of the evolving engineered tissue before implantation. Engelmayr et al. [1] showed the synergistic benefits of combined flexural and fluid induced stresses on valvular-like tissue grown on rectangular scaffold strips. However, for clinical translation to be realized, it is important to determine if the nature of extracellular matrix production in such mechanistic studies also occurs at the macro-level, in the intact tri-leaflet valve geometry. Therefore, appropriate organ-level studies are required wherein the valvular tissues are subjected to the complex 3-dimensional flow/flexure/stretch regimes under highly controlled sub-, normal, and hyper-physiological flow levels. In this manner, biomechanical factors contributing to engineered tissue development can be coupled to tri-leaflet valve geometry requirements. In this study, one possible conditioning strategy on tri-leaflet TEHV structures is presented.
Catalogue of X-Ray Texture Data for Al-Cu-Li Alloy 1460, 2090, 2096 and 2195 Near-Net-Shape Extrusions, Sheet and Plate (1998)

The effect of crystallographic texture on the mechanical properties of near-net-shape extrusions is of major interest ff these products are to find application in launch vehicle or aircraft structures. The objective of this research was to produce a catalogue containing quantitative texture information for extruded product, sheet and plate. The material characterized was extracted from wide, integrally stiffened panels fabricated from the Al-Cu-Li alloys 1460, 2090, 2096 and 2195. The textural characteristics of sheet and plate products of the same alloys were determined for comparison purposes. The approach involved using X-ray diffraction to generate pole figures in combination with orientation distribution function analysis. The data were compiled as a function of location in the extruded cross-sections and the variation in the major deformation- and recrystallization-related texture components was identified.
A simulation-based defect disposition flow for incoming mask quality assurance (2005)

As the industry transitions to 90 and 65nm photolithography, the increased complexity and costs of advanced photomask remain an industry focus. Mask makers and wafer fabs must develop new techniques in photomask inspection and quality control to improve turnaround time and ultimately the mask and wafer production yield. Specific to wafer fabs, this requires an increased focus on the incoming quality control techniques combined with improved communication with the mask shop. For incoming mask inspection "mask-level" defect inspection and dispositioning is no longer adequate. Aggressive OPC on PSM masks, combined with tighter CD requirements increases the burden on both machine and operator increasing the risk of mission a killer defect. For 90nm and beyond, simulation-based defect disposition techniques will be required to predict the wafer-level printing behavior and disposition the defects appropriately. A simulation-based defect disposition flow using Synopsys's i-Virtual Stepper System (iVSS) for incoming mask quality assurance is presented in this study. This paper will examine the feasibility of implementing such a flow from a wafer-fab operation point of view. What kind of benefits can be achieved and how it works will be also presented.
Joint iterative parameter estimation from the Cram&#x00E9;r-Rao lower bound for an OFDM system (2008)

Orthogonal frequency division multiplexing (OFDM) has become a popular wireless data transmission technique and has been adopted into several standards like IEEE 802.11 (WiFi) and IEEE 802.16 (WiMAX). Some of the unknown parameters related to a typical OFDM system include sampling frequency offset, RF oscillator frequency offset, phase noise and the channel coefficients. Inaccurate estimation of these parameters results in a system degradation and poses a severe impairment to high speed communication. In this paper we propose a joint iterative parameter estimation technique for a single-input single-output (SISO) OFDM system which is derived from the generalized framework of the Cramer-Rao lower bound (CRLB).
Standardized definitions and clinical endpoints in carotid artery and supra‐aortic trunk revascularization trials (2010)

Considering the broad consensus between the multidisciplinary scientific members and the regulatory authorities, the proposed definitions are expected to find adoption in future clinical investigations. These definitions can be applied to both endovascular and open surgery trials and will allow reliable comparisons between these two revascularization methods.
Suzuki-Miyaura Cross-Coupling of Unprotected, Nitrogen-Rich Heterocycles: Substrate Scope and Mechanistic Investigation (2013)

The Suzuki-Miyaura cross-coupling of unprotected, nitrogen-rich heterocycles using precatalysts P1 or P2 is reported. The procedure allows for the reaction of variously substituted indazole, benzimidazole, pyrazole, indole, oxindole, and azaindole halides under mild conditions in good to excellent yields. Additionally, the mechanism behind the inhibitory effect of unprotected azoles on Pd-catalyzed cross-coupling reactions is described based on evidence gained through experimental, crystallographic, and theoretical investigations.
Advanced Dataflow Programming using Actor Machines for High-Level Synthesis (2020)

The use of parallelism has increased drastically in recent years. Parallel platforms come in many forms: multi-core processors, embedded hybrid solutions such as multi-processor system-on-chip with reconfigurable logic, and cloud datacenters with multi-core and reconfigurable logic. These heterogeneous platforms can offer massive parallelism, but it can be difficult to exploit, particularly when combining solutions constructed with multiple architectures. To program a heterogeneous platform, a developer must master different programming languages, tools, and APIs to program each aspect of platform separately and then must find a means to connect them with communication interfaces. The motivation of this work is to provide a single programming model and framework for hardware-software stream programs on heterogeneous platforms. Our framework, StreamBlocks, starts with a dataflow programming model for both embedded and datacenter platforms. Dataflow programming is an alternative model of computation that captures both data and task parallelism. We describe a compiler infrastructure for CAL dataflow programs for hardware code generation. CAL is a dataflow programming language that can express multiple dataflow models of computation. StreamBlocks is based on the Tycho compiler infrastructure, which transforms each actor in a dataflow program to an abstract machine model, called Actor Machine. Actor Machines provides a unified model for executing actors in both hardware and software and permit our compiler extension and backend to generate efficient FPGA code. Unlike other systems, the programming model and compiler directly support hardware-software systems in which an FPGA functions as a coprocessor to a CPU. This permits easy integration with existing workflows.
Interface Structure of Cu Wire Bonding on Cu Substrate with Sn Plating (2014)

In previous research on copper wire bonding on a copper substrate with tin plating, suitable thickness and binding conditions for the tin plating were chosen using the peel test after the copper wire bonding. These conditions were determined to be a thickness of 10 μm, a stage temperature of 373 K, a bonding power of 500 to 700 mW and a bonding time of 30 to 50 ms. Cross-sectional observations of the bonding interface indicated that the tin layer remained between the copper wire and copper substrate after bonding under these conditions. The purpose of the present study was to evaluate the joint interface structure of the bonded copper wire on the copper substrate with the tin plating. Residual Sn exists locally at the initial bonding interface, and the locations bonded to the interstitial Sn are intermixed with the locations where the Cu wire is bonded to a Cu-Sn intermetallic compound. No oxide film layer was found at the bonding interface in the joint between the Cu wire and Cu-Sn intermetallic compound; TEM images indicated that these have metallic bonding in which Cu and Cu3Sn are directly bonded. This is in contrast to ultrasonic bonding between Cu and Sn, wherein the Cu and Sn are bonded by means of the Sn oxide film.
Aerosol Delivery During Continuous High Frequency Oscillation for Simulated Adults During Quiet and Distressed Spontaneous Breathing (2019)

Inhaled dose with a jet nebulizer via the Metaneb CHFO device was lower than with a jet nebulizer alone. Placement of a vibrating mesh nebulizer at the airway and distressed breathing increased inhaled dose.
ChemInform Abstract: Spiro‐1,3,4,6‐tetrathiapentalene‐2‐thiones. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Optically-based Molecularly Imprinted Polymers Sensors (2017)

Molecularly imprinted polymers (MIPs) are biologically-inspired materials with capability of replacing their natural counterparts, such as antibodies or enzymes. MIPs have potential as artificial sensing units, just like biosensors. In this presentation, we will report on our optically-based MIP sensor developments with special emphasis on their analytical applications.
Concurrent Multi-Band Envelope Modulated Power Amplifier Linearized Using Extended Phase-Aligned DPD (2014)

This paper reports an envelope tracking (ET) transmitter architecture for multi-band/widely-spaced carrier signals. Due to the bandwidth limitations of the envelope modulator, the dynamic supply voltage is controlled by combining the low frequency envelopes of the multi-inputs rather than the true composite envelope of the input signals. The ET transmitter is tested for dual-band and tri-band power amplifiers (PAs) operating in concurrent mode using various bandwidth carrier aggregated long term evolution (LTE) signals. The transmitter is linearized using a phase-aligned Volterra digital predistortion that considers the inter-modulation distortion (IMD) products around the carrier frequencies as well as the third-order IMD products in the tri-band case. Experimental results are shown to validate the proposed techniques for linearization and efficiency enhancement of the multi-band ET transmitter and compared to the case of fixed supply biasing of the PA.
Abstract TP101: Intra-arterial IL-1α is Well Tolerated and Neuroprotective After Experimental Ischemic Stroke (2017)

Endovascular thrombectomy and t-PA are the only current standard of care treatments for emergent large vessel occlusion (ELVO) stroke. Despite rising recanalization rates, stroke remains the leading cause of long-term disability worldwide suggesting that additional therapies are needed. Severe stroke morbidity may be due, in part, to the acute and sustained inflammatory stroke response. Preclinical research has supported anti-inflammatory agents in limiting brain injury and improving functional outcome; however, the post-stroke inflammatory cascade appears to have both beneficial and deleterious effects, necessitating careful therapeutic translation. We have recently demonstrated that delayed (3 day) post-stroke intravenous (IV) administration of the interleukin (IL)-1α (one of the two major isoforms of the pro-inflammatory family of cytokine IL-1), promoted, rather than suppressed, post-stroke angiogenesis in the transient middle cerebral artery occlusion (MCAo) mouse model. In this study, we aimed to show a therapeutic efficacy of IL-1α in neuroprotection. We investigated the potential for IL-1α, administered acutely IV or intra-arterial (IA) (n=5) after mouse MCAo, to also be neuroprotective. We noted that IV IL-1α (1 ng) is neuroprotective (as measured by cresyl violet stained infarct volumes) with mild, transient side effects (blunted hypertension and bradycardia) that were well tolerated, and with better functional recovery in free motion behavioral tests. IA IL-1α (0.1 ng) administration was even more neuroprotective without the systemic changes seen with IV treatment. Additionally, we noted that IL-1α is directly neuroprotective of primary mouse cortical neurons exposed to oxygen and glucose deprivation conditions in vitro . Taken together, these results suggest that IL-1α could be therapeutic after stroke when administered IV or IA, and the latter may eliminate potentially harmful hemodynamic side effects.
Metallothionein accumulation may account for intracellular copper retention in Menkes' disease. (1982)

Cultured lymphoblasts derived from infants with Menkes' disease exhibit the same increased avidity for copper as do fibroblasts and most extrahepatic tissues from these patients. The Menkes' cells preferentially take up not only copper but also, on exposure to elevated metal concentrations, the other metallothionein-binding metals, zinc and cadmium. Menkes' lymphoblasts contain larger amounts of metallothionein than normal cells following exposure to each of these metals; the amount bound to this protein quantitatively accounted for the total cellular increment in metal in Menkes' cells. Induction of metallothionein synthesis caused both normal and Menkes' cells to subsequently take up increased amounts of 67Cu. These observations suggest that an enhanced capacity of Menkes' cells to accumulate metallothionein may be responsible for their increased uptake and retention of copper.