gebhart/patrepeval huggingface dataset:
Conformations of protonated gas-phase bradykinin ions: evidence for intramolecular hydrogen bonding (1999)

The post-source decay of bradykinin, Lys1-bradykinin, des-Arg1-bradykinin, des-Arg9-bradykinin and [D-Phe7]-bradykinin [M + H]+ ions was examined in order to assertain the influence of secondary structure on peptide ion dissociation. Fragment ions corresponding to the elimination of H2O and HN=C=NH are observed in the product ion mass spectra of Lys1-bradykinin and des-Arg1-bradykinin but not in the spectra of bradykinin or des-Arg9-bradykinin. Cleavage reactions at the Phe-Ser and/or Ser-Pro bonds are observed for all peptide [M + H]+ ions with the exception of des-Arg9-bradykinin. The product ions arising from the processes described above are rationalized in terms of the intramolecular solvation of the protonated guanidino groups of the arginines. The strongest intramolecular interaction appears to be a proton bridge between the guanidino groups of the N- and C-terminal arginines in bradykinin. In addition, increased abundances of fragment ions in the vicinity of Ser-Pro may be attributed to intramolecular solvation of the protonated C-terminal guanidino group by the Ser-Pro portion of the molecule. This self-solvation of the ionizing proton leads to a gas-phase peptide conformation that is supported by solution-phase NMR studies at elevated temperatures and in non-polar solvents but which is different from the conformation in polar solvents.
Microwave Wireless Powering of Sensored Agricultural Tile Drainages (2020)

In this article, a new technique for wireless powering of agricultural sensors buried deep underground is introduced and experimentally investigated. In this technique, the agricultural drainage tiles are utilized as waveguides to carry electromagnetic (EM) energy over long distances. By using high-efficiency rectifiers, the propagating EM waves are then converted into dc power to charge the batteries of underground sensors. A prototype 1 GHz rectenna system is fabricated and implemented on an 8 in tile to prove this concept experimentally. Various measurements are conducted for both the rectenna and the entire tile system, including realistic scenarios such as partially covered tiles and tile in the presence of water. Considering the emerging digital agriculture, the proposed technique will open the potential for detailed underground geochemistry studies, which will allow us to better monitor the transport of liquids and gases through millions of miles of agricultural tile drainage networks.
Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates (2023)

Blocking the PD-1 immune checkpoint with intermittent antibody dosing is well tolerated and associated with evidence of antitumor activity. Exploration of alternative dosing regimens and combinatorial therapies with vaccines, targeted therapies, and/or other checkpoint inhibitors is warranted.
Synthesis of 4,6‐disubstituted‐7‐β‐D‐ribofuranosyl‐ and arabinofuranosylpyrazolo[3,4‐d]pyrimidines and certain related ribonucleosides (1991)

Abstract Several disubstituted pyrazolo[3,4‐ d ]pyrimidine, pyrazolo[1,5‐ a ]pyrimidine and thiazolo[4,5‐ d ]pyrimidine ribonucleosides have been prepared as congeners of uridine and cytidine. Glycosylation of the trimethylsilyl (TMS) derivative of pyrazolo[3,4‐ d ]pyrimidine‐4,6(1 H ,5 H ,7 H )‐dione ( 4 ) with 1‐ O ‐acetyl‐2,3,5‐tri‐ O ‐benzoyl‐D‐ribofuranose ( 5 ) in the presence of TMS triflate afforded 7‐(2,3,5‐tri‐ O ‐benzoyl‐β‐D‐ribofuranosyl)pyrazolo‐[3,4‐ d ]pyrimidine‐4,6(1 H ,5 H )‐dione ( 6 ). Debenzoylation of 6 gave the uridine analog 7‐β‐D‐ribofuranosylpyrazolo[3,4‐ d ]pyrimidine‐4,6(1 H ,5 H )‐dione ( 3 ), identical with 7‐ribofuranosyloxoallopurinol reported earlier. Thiation of 6 gave 7 , which on debenzoylation afforded 7‐β‐D‐ribofuranosyl‐6‐oxopyrazolo[3,4‐ d ]pyrimidine‐4(1 H ,5 H )‐thione ( 8 ). Ammonolysis of 7 at elevated temperature gave a low yield of the cytidine analog 4‐amino‐7‐β‐D‐ribofuranosylpyrazolo[3,4‐ d ]pyrimidin‐6(1 H )‐one ( 11 ). Chlorination of 6 , followed by ammonolysis, furnished an alternate route to 11 . A similar glycosylation of TMS‐4 with 2,3,5‐tri‐ O ‐benzyl‐α‐D‐arabinofuranosyl chloride ( 12 ) gave mainly the N7‐glycosylated product 13 , which on debenzylation provided 7‐β‐D‐arabinofuranosylpyrazolo[3,4‐ d ]pyrimidine‐4,6(1 H ,5 H )‐dione ( 14 ). 4‐Amino‐7‐β‐D‐arabinofuranosyl‐pyrazolo[3,4‐ d ]pyrimidin‐6(1 H )‐one ( 19 ) was prepared from 13 via the C4‐pyridinium chloride intermediate 17 . Condensation of the TMS derivatives of 7‐hydroxy‐ ( 20 ) or 7‐aminopyrazolo[1,5‐ a ]pyrimidin‐5(4 H )‐one ( 23 ) with 5 in the presence of TMS triflate gave the corresponding blocked nucleosides 21 and 24 , respectively, which on deprotection afforded 7‐hydroxy‐ 22 and 7‐amino‐4‐β‐D‐ribofuranosylpyrazolo[1,5‐ a ]pyrimidin‐5‐one ( 25 ), respectively. Similarly, starting either from 2‐chloro ( 26 ) or 2‐aminothiazolo[4,5‐ d ]pyrimidine‐5,7‐(4 H ,6 H )‐dione ( 29 ), 2‐amino‐4‐β‐D‐ribofuranosylthiazolo[4,5‐ d ]pyrimidine‐5,7(6 H )‐dione ( 28 ) has been prepared. The structure of 25 was confirmed by single crystal X‐ray diffraction studies.
Discordant expression of matriptase, prostasin and their endogenous inhibitor hepatocyte growth factor activator inhibitor-1 (HAI-1) is associated with placental labyrinth defects in mice (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4378 

Hepatocyte growth factor activator inhibitor-1 (HAI-1) is a membrane-associated bi-Kunitz type serine protease inhibitor that regulates cell surface and extracellular serine proteases involved in tissue remodeling and tumorigenesis, such as prostasin, matriptase, hepsin and HGFA. The importance of HAI-1 during early development was demonstrated in HAI-1 deficient mice, which displayed a defective placental labyrinth morphology resulting in embryolethality. In order to gain insight into the underlying molecular mechanisms, we characterized HAI-1 deficient mice (generated by Lexicon Genetics). The homozygous HAI-1−/− embryos died between E10.5 and E11.5 due to attenuated vascularization of the placental labyrinth, consistent with the phenotype reported previously. HAI-1 was expressed in the trophoblast cell lineage in the chorionic placenta, as well as in the branchial arches, otic vesicles and limb buds in the embryo at E9.5. However, the vascularization in the HAI-1−/− embryo appeared normal, indicating that HAI-1 did not regulate vascularization directly. In-situ hybridization using cell type-specific markers showed that the trophoblast cells in the HAI-1−/− placenta failed to form a branching morphology. The expression of glial cell missing-1 (Gcm1), a transcription factor defining trophoblast branching sites, was not altered in the trophoblast cells along the chorioallantoic interface. examination of HAI-1 target protease expression by RT-PCR revealed that matriptase and prostasin were expressed in both wildtype and HAI-1−/− placentas, whereas neither HGFA nor hepsin were detectable. In-situ hybridization experiments showed matriptase and prostasin expression to co-localize with HAI-1 on the chorionic trophoblast cells of the placental labyrinth. Both the localization and expression of the two proteases remained unchanged in HAI-1−/− placentas, indicating that matriptase and prostasin were no longer regulated by their endogenous inhibitor. Since tight regulation of these proteases by HAI-1 is considered paramount for their physiological function, the complete absence of HAI-1 may have resulted in uncontrolled proteolytic activity towards extracellular matrix components detrimental to branching morphogenesis. These results provide new evidence to further support the concept that the matriptase/prostasin/HAI-1 system plays a critical role in physiological and in pathological processes.
Melamine-based functionalized graphene oxide and zirconium phosphate for high performance removal of mercury and lead ions from water (2020)

Heavy metal ions are highly toxic and widely spread as environmental pollutants. This work reports the development of two novel chelating adsorbents, based on the chemical modifications of graphene oxide and zirconium phosphate by functionalization with melamine-based chelating ligands for the effective and selective extraction of Hg(ii) and Pb(ii) from contaminated water sources. The first adsorbent melamine, thiourea-partially reduced graphene oxide (MT-PRGO) combines the heavier donor atom sulfur with the amine and triazine nitrogen's functional groups attached to the partially reduced GO nanosheets to effectively capture Hg(ii) ions from water. The MT-PRGO adsorbent shows high efficiency for the extraction of Hg(ii) with a capacity of 651 mg g<sup>-1</sup> and very fast kinetics resulting in a 100% removal of Hg(ii) from 500 ppb and 50 ppm concentrations in 15 second and 30 min, respectively. The second adsorbent, melamine zirconium phosphate (M-ZrP), is designed to combine the amine and triazine nitrogen's functional groups of melamine with the hydroxyl active sites of zirconium phosphate to effectively capture Pb(ii) ions from water. The M-ZrP adsorbent shows exceptionally high adsorption affinity for Pb(ii) with a capacity of 681 mg g<sup>-1</sup> and 1000 mg g<sup>-1</sup> using an adsorbent dose of 1 g L<sup>-1</sup> and 2 g L<sup>-1</sup>, respectively. The high adsorption capacity is also coupled with fast kinetics where the equilibrium time required for the 100% removal of Pb(ii) from 1 ppm, 100 ppm and 1000 ppm concentrations is 40 seconds, 5 min and 30 min, respectively using an adsorbent dose of 1 g L<sup>-1</sup>. In a mixture of six heavy metal ions at a concentration of 10 ppm, the removal efficiency is 100% for Pb(ii), 99% for Hg(ii), Cd(ii) and Zn(ii), 94% for Cu(ii), and 90% for Ni(ii) while at a higher concentration of 250 ppm the removal efficiency for Pb(ii) is 95% compared to 23% for Hg(ii) and less than 10% for the other ions. Because of the fast adsorption kinetics, high removal capacity, excellent regeneration, stability and reusability, the MT-PRGO and M-ZrP are proposed as top performing remediation adsorbents for the solid phase extraction of Hg(ii) and Pb(ii), respectively from contaminated water.
Development of an Active Flight Envelope Warning Method for General Aviation Aircraft (2015)

Engineering: 4th Place, Honorable Mention (The Ohio State University Denman Undergraduate Research Forum)
The relationship of dietary fish intake to diabetic retinopathy and retinal vascular caliber in patients with type 2 diabetes (2018)

In this cross-sectional study, we evaluated the association of dietary fish intake with varying severity of diabetic retinopathy (DR) and retinal vascular caliber in Asians with type 2 diabetes mellitus. 357 Asians (median age: 58 years; 31% women; 78% Chinese) were recruited from a tertiary eye care institution in Singapore. Fish consumption was evaluated using a validated food frequency questionnaire. Digital retinal photographs assessed for DR severity and retinal vascular caliber. Ordered logistic and linear regression models were used to investigate the association of fish intake with DR severity and vascular caliber. Increasing frequency of fish consumption was significantly associated with lower odds of having severe DR (odds ratio [OR] = 0.91, 95% CI: 0.84-0.99 per 1-unit increase of fish intake; P = 0.038). Among those with no retinopathy, persons in quartile 4 fish intake had a wider retinal vascular caliber for arteriolar (β = 22.27 µm, 95% CI: 12.64-31.90; P-trend < 0.001) and venular (β = 32.00 µm, 95% CI: 17.56-46.43; P-trend < 0.001), than those in quartile 1 fish intake. Persons with higher fish intake had a decreased likelihood of having severe DR. In diabetics without retinopathy, higher fish intake was associated with wider retinal vascular caliber. Future research is needed to reinforce the direction of the casualty.
Experimental autoimmune keratitis induced in rats by anti-cornea T-cell lines. (1999)

Thus, keratitis may be produced by T cells reactive to corneal antigens, provided that the target tissue has been made susceptible by irradiation. The effectiveness of T-cell vaccination in preventing adoptive keratitis suggests that systemic as well as local tissue factors may regulate the disease process.
Potent pleiotropic anti-angiogenic effects of TM601, a synthetic chlorotoxin peptide. (2010)

TM601 inhibits angiogenesis stimulated by many factors and potentiates the anti-angiogenic effect of bevacizumab.
Reliability of MEMS devices in shock and vibration overload situations (2008)

This contribution describes the investigation of the reasons for overload failure and overload reaction based on linear vibration theory by decomposition of the complex reaction into resonant mode reactions and on observation of the reaction. An impulse specific peak deflection (ISPD) is derived as a general characteristic property of a certain shock. It is applicable to predict the mechanical deflection of a certain resonant mode of an arbitrary resonant frequency due to a shock. This is further analyzed and proofed by scanning Laser Doppler interferometer (SLDI) measurement on the example of a Fabry Perot interferometer based tunable infrared filter. The results from ISPD prediction are compared to SLDI measurements and to finite element analysis results.
A match made in heaven: British Muslim women write about love and desire (2020)

Star-studded and beautifully written, this collection of diverse stories about love and desire by South Asian-heritage British Muslim women authors, including Ayisha Malik and Shelina Janmohamed . <br/><br/>Although outsiders often expect Muslim women to be timid, conservative, or submissive, the reality is different. While some of these authors express a quiet piety and explore poignant situations, others use black humour and biting satire, or play with possibilities. Still others shade into the territory of a Muslim Fifty Shades of Grey, creating grey areas where the mainstream media sees only black and white.<br/><br/>If grooming-gang scandals grab headlines, characters are more scandalized by suitors’ sloppy personal grooming. Finding the right crimson lipstick for a date or the perfect power outfit for meeting a cheating ex-husband are commoner preoccupations than the news. <br/><br/>Stylish but far from shallow, the stories also reflect on migration, racism, arranged marriage, gender differences, lesbian desire, bearding, and many other subjects .
Perylene Diimide Bearing Different Trialkyl Silyl Ethers: Impact of Asymmetric Functionalization on Self-Assembly into Nanostructures (2018)

For over a decade, a great amount of research effort has focused on controlling the size and shape of organic small molecule crystals, as these parameters impact physical and optoelectronic properties. A thorough understanding of how functionalization impacts assembly as well as guiding principles to control aggregation and self-assembly are vital to producing novel organic nanostructures for electronic applications such as organic photovoltaics (OPVs). Herein, we study the influence of unsymmetrical functionalization of perylene diimide (PDI) on self-assembly. The guiding hypothesis of this work is that the identity of the pendant functionalities will impact the size, aspect ratio, and surface properties of the resulting assemblies. Twelve asymmetrically functionalized PDI molecules are reported, in which the length of the alkyl substituents at the imide position is varied, and include alcohol and silylated alcohol functionalities at the end of the alky chain. Morphologies of these self-assembled structures were characterized by scanning and transmission electronic microscopy; crystallinity was verified by powder X-ray diffraction, and the optoelectronic and thermal properties are also reported. On the basis of the functionality of the PDI molecules, different shaped assemblies are prepared, including high aspect ratio structures with widths ranging from 0.1 to 2.5 μm and lengths 1–800 μm.
Photoinduced Bioorthogonal 1,3‐Dipolar Poly‐cycloaddition Promoted by Oxyanionic Substrates for Spatiotemporal Operation of Molecular Glues (2015)

Abstract PGlue PZ , a pyrazoline (PZ)‐based fluorescent adhesive which can be generated spatiotemporally in living systems, was developed. Since PGlue PZ carries many guanidinium ion (Gu + ) pendants, it strongly adheres to various oxyanionic substrates through a multivalent salt‐bridge interaction. PGlue PZ is given by bioorthogonal photopolymerization of a Gu + ‐appended monomer (Glue TZ ), bearing tetrazole (TZ) and olefinic termini. Upon exposure to UV light, Glue TZ transforms into a nitrileimine (NI) intermediate (Glue NI ), which is eligible for 1,3‐dipolar polycycloaddition. However, Glue NI in aqueous media can concomitantly be deactivated into Glue WA by the addition of water, and the polymerization hardly occurs unless Glue NI is concentrated. We found that, even under high dilution, Glue NI is concentrated on oxyanionic substrates to a sufficient level for the polymerization, so that their surfaces can be point‐specifically functionalized with PGlue PZ by the use of a focused beam of UV light.
Supplementary Tables from Aurora A–Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy (2023)

&lt;p&gt;Supplementary Tables&lt;/p&gt;
Study of the Absorption of Myo-Inositol Hexakisphosphate (InsP6) through the Skin (2005)

Recently, some properties of myo-inositol hexakisphosphate (InsP(6)) are related to its dermatological use as discolouring agent, on preventing calcinosis cutis or due to its important role on premature aging. Some studies also seem to demonstrate a capacity of InsP(6) to inhibit skin cancer. In this paper, a first study of the absorption of InsP(6) through the skin is developed. Due to the correlation between InsP(6) absorption and its urinary excretion, these last values were used to evaluate this process. It was found that using a moisturizing cream as vehicle, the InsP(6) sodium salt was absorbed at significantly higher amounts than the InsP(6) calcium-magnesium salt. Maximum InsP(6) urinary concentrations were observed approximately at 14 d of 2% InsP(6) topical cream application, and gave 66.35+/-5.49 mg/l urinary InsP(6) when the sodium salt was used and 16.02+/-2.61 mg/l urinary InsP(6) when the calcium-magnesium salt was applied. When the InsP(6) topical cream administration ceased, the InsP(6) urinary excretion fell dramatically approximately during a period of 10 d. From these results, it can be deduced that by topical administration InsP(6) can achieve important concentrations in tissues and biological fluids, this demonstrating that it is possible to propose the topic use as a new InsP(6) administration route.
Maternal Ehlers-Danlos Syndrome Type X (1982)

The proposita of the first kindred described with dysfibronectinemic Ehlers-Danlos syndrome conceived and gave birth to a normal, unaffected infant. The ability of the gravida's plasma to support collagen-induced aggregation of normal platelets improved during the pregnancy, perhaps reflecting a change in level or functional status of fibronectin and contributing to the surprisingly normal hemostasis and wound healing she enjoyed. Ehlers-Danlos syndrome type X does not preclude safe childbearing. (<i>JAMA</i>1982;248:2487-2488)
The influence of antibiotic use on the occurrence of vancomycin-resistant enterococci (2006)

While our study confirms the effect of use of glycopeptides and third-generation cephalosporins on occurrence of VRE, no influence of quinolones and lincosamides over the 6-year period was shown.
The Nanoporous RP-20 Carbon Electrode as a Model for Energy Storage and Conversion Systems – Studied with µCT, SAXS and SANS Techniques (2017)

The manuscript describes quantitative morphological and structural information for the nanoporous RP-20 powder andelectrode based on that carbon - studied with X-ray microcomputed tomography, small-angle neutron scattering, and small-angle X-ray scattering techniques. μCT measurements demonstrated that the diffusion process inside of the RP-20 electrode is significantly influenced by the nature of the solvent. SAXS measurements were performed in order to collect quantitative morphological and structural information for nanoporous RP-20 powder-polytetrafluoroethylene binder based electrode material. Comparison of the complementary scattering techniques, i.e., SAXS and SANS has been provided. The interaction of heavy water inside of the nanoporous PR-20 based electrode by SANS technique was observed.
Future devices for information processing (2005)

Current CMOS devices operate at about six orders of magnitude above the k/sub B/Tln2 Joules/bit switching limit imposed by physics. Nevertheless, it can be shown that continued scaling of device features that are then densely packed and operated at attainable frequencies will result in the generation of thermal loads that cannot be managed by any known heat removal technology. We discuss possible successor/complementary logic devices that reduce the level of heat generation and we discuss new nonvolatile memory techniques that could radically impact information processing architectures and hence the performance requirements for logic devices.
Conversion of the Pathogenic FungusColletotrichum magnato a Nonpathogenic, Endophytic Mutualist by Gene Disruption (1999)

Hygromycin-resistant transformants of the cucurbit pathogen Colletotrichum magna (teleomorph: Glomerella magna) were generated by restriction enzyme-mediated integration (REMI) transformation. A rapid pathogenicity assay involving watermelon (Citrullus lanatus) seedlings was developed and 14,400 REMI transformants were screened and assessed for their ability to cause disease, colonize plant tissues, and confer disease resistance against wild-type C. magna. A total of 176 nonpathogenic REMI mutants capable of colonizing cucurbit plants were isolated and assigned to three groups based on their ability to confer disease resistance: phenotype A, 80 to 100% disease protection; phenotype B, 10 to 65% disease protection; and phenotype C, 0 to 4% disease protection. Molecular and genetic analyses of one REMI mutant (R1) indicated that the nonpathogenic phenotype A resulted from a single-site integration. R1 showed a 1:1 segregation of hygromycin resistance and nonpathogenicity and all hygro-mycin-resistant progeny were nonpathogenic. The integrated vector and 5.5 kb of flanking fungal genomic DNA were isolated from R1 and designated pGMR1. To verify that pGMR1 contained pathogenicity gene sequences, a wild-type isolate of C. magna was transformed with pGMR1 to induce gene disruptions by homologous integration. Approximately 47% of the pGMR1 transformants expressed phenotype A, indicating homologous integration and gene disruption.
Commercial Supported Gold Nanoparticles Catalyzed Alkyne Hydroamination and Indole Synthesis (2016)

Abstract Commercial gold nanoparticles supported on titanium dioxide (TiO 2 ) were found to be a highly efficient catalyst for alkyne hydroamination. Terminal alkynes could easily undergo intermolecular hydroamination with low catalyst loadings (0.2 mol% Au) under solvent‐free conditions. Indoles were efficiently synthesized using microwave heating through intramolecular hydroamination. magnified image
Inter-radiologist concordance in pulmonary tuberculosis vs. normal chest x-ray classification to arrive at expected performance level of automated classification (2018)

Poster: ECR 2018 / C-2197 / Inter-radiologist concordance in pulmonary tuberculosis vs. normal chest x-ray classification to arrive at expected performance level of automated classification by: Paul1, M. K. GARG2, S. KALE3, D. T. Kaur4, D. M. Muniraju4, D. S. Sagar4, D. Bystrov5, N. Wieberneit 5, N. Khandelwal4; 1Bangalore/IN, 2CHANDIGARH, UT/IN, 3BANGALORE, KARNATAKA/IN, 4Chandigarh/IN, 5Hamburg/DE