gebhart/patrepeval huggingface dataset:
Hypothalamic sodium-transport inhibitor is a high-affinity reversible inhibitor of Na+-K+-ATPase (1984)

Bovine hypothalamus contains a stable, low molecular weight substance with ouabain-like properties. To further study its mechanism of action and potential physiological importance we examined its effects on purified Na+-K+-ATPase in a kinetic coupled-enzyme assay. Under optimal conditions up to 95% of Na+-K+-ATPase activity could be inhibited by the factor. Mg2+ is required for maximal inhibitory activity, but ligand requirements for optimal activity are otherwise distinct from those of both ouabain and vanadate. Inhibition is reversed by high concentrations of sodium chloride plus EDTA. Kinetic analysis yielded a Ki = 1.4 nM. The hypothalamic factor is a high-affinity reversible inhibitor of Na+-K+-ATPase, being at least as potent as the cardiac glycoside ouabain and may be a circulating inhibitor of sodium transport, which appears to be associated with experimental volume-expanded hypertension and human essential hypertension.
Properties of polyamide 6,10/poly(vinyl alcohol) blends and impact on oxygen barrier performance (2017)

Abstract The oxygen transmission rate, average volume of free‐volume cavities ( V f ) and fractional free volume ( F v ) of polyamide 6,10 (PA610)/poly(vinyl alcohol) (PVA) (i.e. PA610 x PVA 05 y , PA610 x PVA 08 y and PA610 x PVA 14 y ) blend films reduced to minimum values when their PVA contents reached corresponding optimal values. Oxygen transmission rate, V f and F v values obtained for optimal PA610 x PVA z y blown films were reduced considerably with decreasing PVA degrees of polymerization. The oxygen transmission rate of the optimal bio‐based PA610 80 PVA 05 20 blown film was only 2.4 cm 3 (m 2 ·day·atm) −1 , which is about the same as that of the most often used high‐barrier polymer, ethylene–vinyl alcohol copolymer. Experimental findings from dynamic mechanical analysis, differential scanning calorimetry, wide‐angle X‐ray diffraction and Fourier transform infrared spectroscopy of the PA610 x PVA z y blends indicate that PA610 and PVA in the blends are miscible to some extent at the molecular level when the PVA contents are less than or equal to the corresponding optimal values. The considerably enhanced oxygen barrier properties of the PA610 x PVA z y blend films with optimized compositions are attributed to the significantly reduced local free‐volume characteristics. © 2017 Society of Chemical Industry
Supplementary Table 2 from <i>HIST1H2BB</i> and <i>MAGI2</i> Methylation and Somatic Mutations as Precision Medicine Biomarkers for Diagnosis and Prognosis of High-grade Serous Ovarian Cancer (2023)

&lt;p&gt;Survival alleles at SNV level&lt;/p&gt;
Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I (2006)

A series of compounds based on the carboxyl-terminal CAAL sequence of PGGTase-I substrates was designed and synthesized. Using piperazin-2-one as a semi-rigid scaffold, we have introduced critical pharmacophores in a well-defined arrangement to mimic the CAAL sequence. High potency and exceptional selectivity were obtained for inhibition of PGGTase-I with structures such as 45 and 70. Potency of this series of GGTIs was dependent on the presence of an L-leucine residue with a free carboxyl terminus, as well as an S configuration of the 3-aryl group. The selectivity was significantly enhanced by 5-methyl substitution on the imidazole ring and fluorine substitution on the 3-aryl group. Modification of the 6-position of the piperazinone scaffold was found to be unfavorable. Compounds 44 and 69, the corresponding methyl esters of 45 and 70, were found to selectively block processing of Rap1A by PGGTase-I in whole cells with IC(50) values of 0.4 microM and 0.7 microM respectively.
Quantitative assessment of myocardial viscoelastic properties using shear wave imaging (2012)

International audience
Efficient WiMAX Receiver Implementation on a Programmable Baseband Processor (2006)

WiMAX provides broadband wireless access and uses OFDM as the underlying modulation technique. In an OFDM based wireless communication system, the channel will distort the transmitted signal and the performance is seriously degraded by synchronization mismatches between the transmitter and receiver. Therefore such systems require extensive digital signal processing of the received signal for retrieval of the transmitted information. In this master thesis, parts of an IEEE 802.16d (WiMAX) receiver have been implemented on a programmable baseband processor. The implemented parts constitute baseband algorithms which compensates for the effects from the channel and synchronization errors. The processor has a new innovative architecture with an instruction set optimized for baseband applications. This report includes theory behind the baseband algorithms as well as a presentation of how they are implemented on the processor. An impartial evaluation of the processor performance with respect to the algorithms used in the reference model is also presented in the report.
Yb-doped LMA triple-clad fiber for power amplifiers (2007)

High-energy pulsed narrow-linewidth diffraction-limited ytterbium-doped power amplifiers in the 1030 to 1100 nm wavelength range and in the nanosecond regime require large mode area (LMA) fibers to mitigate stimulated Brillouin scattering (SBS). However, typical LMA fibers with mode-field diameters larger than 20 &mgr;m are inherently multimode. To achieve a diffraction-limited output, several techniques are available such as low core numerical aperture, fiber coiling and selective doping. The triple-clad fiber design takes advantage of the three techniques. The first clad located next to the core allows a reduction and a better control of the effective numerical aperture for high ytterbium doping that is difficult to achieve with the standard double-clad fiber design. Also, the thickness of the first clad gives an extra degree of freedom that allows either a nearly bending-insensitive output or mode filtering through bending losses that can be enhanced by a depressed-clad design. Incorporating to the triple-clad design an optimized selective rare-earth doping of the core favors the fundamental mode over higher-order modes by the gain differential. Using the right dopants, it can also favor SBS suppression by reducing the overlap between optical and acoustic field distributions. Ytterbium-doped LMA triple-clad fibers with a large depressed first clad and selective ytterbium doping are tested in a power amplifier configuration. Also, ytterbium-doped polarization-maintaining LMA triple-clad fibers with a thin first clad are tested for SBS.
Artroplastía total de cadera sin cementación de segunda generación (2001)

JBJS was founded by the American Orthopaedic Association in 1903 and is the Official Journal of the American Orthopaedic Association. EXCELLENCE THROUGH PEER REVIEW The Journal of Bone & Joint Surgery (JBJS) has been the most valued source of information for orthopaedic surgeons and researchers for over 125 years and is the gold standard in peer-reviewed scientific information in the field. A core journal and essential reading for general as well as specialist orthopaedic surgeons worldwide, JBJS publishes evidence-based research to enhance the quality of care for orthopaedic patients. Standards of excellence and high quality are maintained in everything we do, from the science of the content published to the customer service we provide. JBJS is an independent, non-profit journal. JBJS.org is the version of record of The Journal of Bone & Joint Surgery. JBJS is published twice a month on the first and third Wednesday of each month, each time adding to a comprehensive PDF archive dating back to 1889. Additional features online include: article commenting, social sharing links, instructional videos, podcasts, and continuing medical education activities. Contributions from anywhere in the world are welcome and considered on their merits. The manuscript must be written in English and should be submitted as outlined in the Instructions for Authors. Manuscripts are subject to blinded peer review by experts and a final decision by the editor. Papers are judged by the quality and relevance of the work. Our aim is to publish the best material available from anywhere in the world.
A New Synthesis of Pyrimido[4,5-b][1,5]benzodiazepin-2-one and -2-thione Derivatives (1987)

Derivatives of pyrimido[4,5-blIl.5lbenzodiazepin-2-one and -2-thione were synthesized by intramolecular cyclization of N-(3-cyano-1X-1 ,5-benzodlazepln-4-y1)-N'-alkylureas and -N'-phenylthiourea which were obtained by reactions of 4-amino-
Infrared spectroelectrochemical study of cyanide adsorption on palladium surfaces (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfrared spectroelectrochemical study of cyanide adsorption on palladium surfacesKevin Ashley, Frederick Weinert, Mahesh G. Samant, H. Seki, and Michael R. PhilpottCite this: J. Phys. Chem. 1991, 95, 19, 7409–7414Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September 1991https://pubs.acs.org/doi/10.1021/j100172a055https://doi.org/10.1021/j100172a055research-articleACS PublicationsRequest reuse permissionsArticle Views277Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
66.2: Invited Paper : Highly Efficient White OLEDs with over 100 lm/W for General Lighting (2013)

Abstract High‐performance all‐phosphorescent white devices on a light‐outcoupling substrate which comprised high‐index materials were studied. As a result of suitable optical and electrical design, the device showed an extremely high efficacy of 114 lm/W at 1,000 cd/m 2 and 102 lm/W at 3,000 cd/m 2 .
“Uni et Trini”: In Situ Diversification of (Pyridylamide)hafnium(IV) Catalysts (2009)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXT"Uni et Trini": In Situ Diversification of (Pyridylamide)hafnium(IV) CatalystsVincenzo Busico†, Roberta Cipullo†, Roberta Pellecchia†, Luca Rongo†, Giovanni Talarico†, Alceo Macchioni‡, Cristiano Zuccaccia‡, Robert D. J. Froese§, and Phillip D. Hustad⊥*View Author Information† Department of Chemistry, University of Napoli, Via Cintia, 80126, Napoli, Italy‡ Department of Chemistry, University of Perugia, Via Elce di Sotto, 8−06123, Perugia, Italy§ The Dow Chemical Company, Building 1776, Midland, Michigan 48674⊥ The Dow Chemical Company, 2301 North Brazosport Boulevard, B-1814, Freeport, Texas 77541*Corresponding author. E-mail: [email protected]Cite this: Macromolecules 2009, 42, 13, 4369–4373Publication Date (Web):June 17, 2009Publication History Received9 April 2009Revised8 June 2009Published online17 June 2009Published inissue 14 July 2009https://pubs.acs.org/doi/10.1021/ma900780xhttps://doi.org/10.1021/ma900780xrapid-communicationACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views1205Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alkyls,Catalysts,Hydrocarbons,Polymerization,Polymers Get e-Alerts
MULTIWALLED CARBON NANOTUBE-BASED AROMATIC HYDROCARBON SENSOR USING ELECTRONIC DIPOLE SPECTROSCOPY (2007)

A novel electronic spectroscopy technique based on dipole-dipole interactions for the identification of chemical analytes has been developed. This technique is based on the measurement of the charge transfer of chemical analytes to a multiwalled carbon nanotube mat-based sensing system. This technique was used for the identification of three aromatic hydrocarbons, namely, benzene, toluene, and xylene, at 100 parts-per-billion concentration. This technique was evaluated with multiwalled carbon nanotube mats for rapid, reliable, and robust identification of the three chemicals that belong to the same genre. The technique involves the identification of electronic spectral signatures of these chemicals using frequency domain analysis of the voltage signals generated by the binding of the chemical analytes onto the multiwalled carbon nanotube mat surfaces. This technique has the potential for rapid and accurate identification of multiple chemical analytes in a multiplexed fashion using a single-sensor device. In addition, this particular device configuration in conjunction with the electronic dipole spectroscopy results is a powerful lab-on-a-chip device for chemical and biological sensing applications.
Power to Pursue Happiness (2023)

Abstract The Declaration of Independence lists the “pursuit of Happiness” as one of the rights that government is duty-bound to protect. Yet in the United States, decades of conservative and neoliberal policies have made that right illusory for far too many. By several metrics-economic inequality, life expectancy, and the alarming growth in so-called deaths of despair-it has become clear that the government has failed to provide most Americans with a basic level of security, much less with the chance to pursue lives of meaning and connectedness. A major reason for this failure is the distortion of the American political system, which is increasingly beholden to a small minority. We need a renaissance of civic engagement and local activism to challenge the systemic barriers to well-being, restore our democracy, and make our government attentive to public happiness in all its dimensions.
ChemInform Abstract: Remarkable Rate Enhancement Effect of the o‐Methoxy Group in the Nucleophilic Substitution Reactions at the Phosphorus of Phosphine‐ Boranes. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
<title>Approximate Poisson likelihoods for simple optimization in MAP tomographic estimation</title> (1999)

Emission Computed Tomography (ECT) is widely applied in medical diagnostic imaging, especially to determine physiological function. The available set of measurements is,however, often incomplete and corrupted, and the quality of image reconstruction is enhanced by the computation of a statistically optimal estimate. We present here a numerical method of ECT image reconstruction based on a Taylor series quadratic approximation to the usual Poison log-likelihood function. The quadratic approximation yields simplification in understanding and manipulating Poisson models. We introduce an algorithm similar to global Newton methods which updates the point of expansion a limited number of time sand we give quantitative measures of the accuracy of the reconstruction. The result show little difference in quality from those obtained with the exact Poisson model.
The potential probiotic Lactobacillus rhamnosus CNCM I-3690 strain protects the intestinal barrier by stimulating both mucus production and cytoprotective response (2019)

The gut barrier plays an important role in human health. When barrier function is impaired, altered permeability and barrier dysfunction can occur, leading to inflammatory bowel diseases, irritable bowel syndrome or obesity. Several bacteria, including pathogens and commensals, have been found to directly or indirectly modulate intestinal barrier function. The use of probiotic strains could be an important landmark in the management of gut dysfunction with a clear impact on the general population. Previously, we found that Lactobacillus rhamnosus CNCM I-3690 can protect intestinal barrier functions in mice inflammation model. Here, we investigated its mechanism of action. Our results show that CNCM I-3690 can (i) physically maintain modulated goblet cells and the mucus layer and (ii) counteract changes in local and systemic lymphocytes. Furthermore, mice colonic transcriptome analysis revealed that CNCM I-3690 enhances the expression of genes related to healthy gut permeability: motility and absorption, cell proliferation; and protective functions by inhibiting endogenous proteases. Finally, SpaFED pili are clearly important effectors since an L. rhamnosus ΔspaF mutant failed to provide the same benefits as the wild type strain. Taken together, our data suggest that CNCM I-3690 restores impaired intestinal barrier functions via anti-inflammatory and cytoprotective responses.
Die Chancen der digitalen Mamma-Tomosynthese: Phantomexperimente mit einem Prototypgerät (2006)

Problemstellung: Bildqualitätsvergleich von digitalen Projektionsbildern mit rekonstruierten Tomosyntheseschichten, die mit einem Prototypen für die Mamma-Tomosynthese gewonnen wurden.
The Outcome of Tendon Transfers for C6-Spared Quadriplegics (1998)

The purpose of this study was to review retrospectively and evaluate a uniform group of C6-spared quadriplegics who had similar surgical procedures. Eight patients undergoing 12 procedures were reviewed at an average of 3.8 years follow-up. There were three bilateral procedures. All patients had extensor carpi radialis longus to flexor digitorum profundus and brachioradialis to flexor pollicis longus transfers to improve grip strength and key pinch. All patients reported subjective improvements in quality of life, activities of daily living and patient-centred goals. There were six excellent and two good results. Objective improvements included mild improvements in key pinch and grip strength.
Blockade of Protein Geranylgeranylation Inhibits Cdk2-Dependent p27Kip1 Phosphorylation on Thr187 and Accumulates p27Kip1 in the Nucleus: Implications for Breast Cancer Therapy (2009)

We describe the design of a potent and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI), GGTI-2418, and its methyl ester GGTI-2417, which increases the levels of the cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) and induces breast tumor regression in vivo. Experiments with p27(Kip1) small interfering RNA in breast cancer cells and p27(Kip1) null murine embryonic fibroblasts demonstrate that the ability of GGTI-2417 to induce cell death requires p27(Kip1). GGTI-2417 inhibits the Cdk2-mediated phosphorylation of p27(Kip1) at Thr187 and accumulates p27(Kip1) in the nucleus. In nude mouse xenografts, GGTI-2418 suppresses the growth of human breast tumors. Furthermore, in ErbB2 transgenic mice, GGTI-2418 increases p27(Kip1) and induces significant regression of breast tumors. We conclude that GGTIs' antitumor activity is, at least in part, due to inhibiting Cdk2-dependent p27(Kip1) phosphorylation at Thr187 and accumulating nuclear p27(Kip1). Thus, GGTI treatment might improve the poor prognosis of breast cancer patients with low nuclear p27(Kip1) levels.
Bispecific Engineered Antibody Domains (Nanoantibodies) That Interact Noncompetitively with an HIV-1 Neutralizing Epitope and FcRn (2012)

Libraries based on an isolated human immunoglobulin G1 (IgG1) constant domain 2 (CH2) have been previously diversified by random mutagenesis. However, native isolated CH2 is not very stable and the generation of many mutations could lead to an increase in immunogenicity. Recently, we demonstrated that engineering an additional disulfide bond and removing seven N-terminal residues results in an engineered antibody domain (eAd) (m01s) with highly increased stability and enhanced binding to human neonatal Fc receptor (FcRn) (Gong et al, JBC, 2009 and 2011). We and others have also previously shown that grafting of the heavy chain complementarity region 3 (CDR-H3 (H3)) onto cognate positions of the variable domain leads to highly diversified libraries from which a number of binders to various antigens have been selected. However, grafting of H3s to non-cognate positions in constant domains results in additional residues at the junctions of H3s and the CH2 framework. Here we describe a new method based on multi-step PCR that allows the precise replacement of loop FG (no changes in its flanking sequences) by human H3s from another library. Using this method and limited mutagenesis of loops BC and DE we generated an eAd phage-displayed library. Panning of this library against an HIV-1 gp41 MPER peptide resulted in selection of a binder, m2a1, which neutralized HIV-1 isolates from different clades with modest activity and retained the m01s capability of binding to FcRn. This result provides a proof of concept that CH2-based antigen binders that also mimic to certain extent other functions of full-size antibodies (binding to FcRn) can be generated; we have previously hypothesized that such binders can be made and coined the term nanoantibodies (nAbs). Further studies in animal models and in humans will show how useful nAbs could be as therapeutics and diagnostics.
Electrochemically Active Cross‐Linking Reaction for Fluorescent Labeling of Aliphatic Alkenes (2012)

Although cross-linking reactions serve as a valuable tool for the integration of two or more functionalities or properties, the application of electrochemical synthesis to cross-linking reactions is restricted due to the difficulty of mass transfer. Thus, the primary purpose of this research is to explore electrochemical cross-linking systems to construct a fluorescent probe, triggered by the formation of a covalent linkage. The second purpose is to apply the probe to insoluble targets. Towards these goals, a combination of electrochemically active phenol derivatives and aliphatic alkenes were employed to form polycyclic compounds. Several of the dihydrobenzofuran derivatives formed through [3+2] cyclization reactions exhibited fluorescence. Furthermore, this approach allowed the effective modification of alkene-modified silica gel with electrochemically active species, which enables the construction of fluorescent probes that are triggered by C-C bond formation.