gebhart/patrepeval huggingface dataset:
Surviving multiple network failures using shared backup path protection (2004)

This paper studies the possibilities of protecting backbone networks from multiple simultaneous failures. Although methods that prepare the networks to survive single failures were extensively studied in the literature, in order to provide extra high availability for mission-critical applications, the possibility of more than one simultaneous failure has to be considered too. The general technique of protecting a traffic flow is to establish a backup path where the traffic is redirected when a failure occurs along its active path. Using this technique the total capacity reservation is at least doubled compared to the non-protected case. To avoid this large amount of bandwidth reservation by the backup paths, the shared backup path protection paradigm can be used, which is a promising scheme favored by the Internet engineering task force. In this paper the two backup path based protection scheme is introduced, which provides survivability against any two simultaneous failures. Further, a novel shared protection strategy is proposed that improves the failure tolerance of the traditional single backup path based protection. The performance of the different protection types is examined through simulations.
Comparison of three distortion product otoacoustic emission devices (2000)

A comparison of noise susceptibility and distortion product otoacoustic emissions (DPOAE) variability was performed using DPOAE device prototype and two different DPOAE recording devices, on a small sample of adults, in quite and noisy conditions. To compare machine susceptibility to noise the effect of background noise level on the measured DPOAE values for each machine was examined. To compare data variability over repeated testing the standard deviations of the DPOAE amplitude values in the `low noise' and `high noise' sections were calculated.
Cost-effective 100Gbps Optical Modulation Format for Metro Networks (2008)

When commercialized, the increase of the per-channel data rate to 100Gbps in transport systems is expected to experience strong demand within both long-haul and metro networks. We explore a modulation format that combines phase- and amplitude-shift keying towards finding a cost-effective higher-speed transport solution for metro networks, significantly reducing the cost-premium associated with several specific solutions being designed for long-haul networks and reducing the wait associated with decreases in component pricing. The respective hardware requirements and possible implementations of the proposed format are discussed, and we present numerical simulation results to explore sensitivities to several system parameters, namely chromatic dispersion tolerances, PMD tolerances, and OSNR requirements.
Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3 (2010)

Vascular sprouting is a key process-driving development of the vascular system. In this study, we show that neuropilin-2 (Nrp2), a transmembrane receptor for the lymphangiogenic vascular endothelial growth factor C (VEGF-C), plays an important role in lymphatic vessel sprouting. Blocking VEGF-C binding to Nrp2 using antibodies specifically inhibits sprouting of developing lymphatic endothelial tip cells in vivo. In vitro analyses show that Nrp2 modulates lymphatic endothelial tip cell extension and prevents tip cell stalling and retraction during vascular sprout formation. Genetic deletion of Nrp2 reproduces the sprouting defects seen after antibody treatment. To investigate whether this defect depends on Nrp2 interaction with VEGF receptor 2 (VEGFR2) and/or 3, we intercrossed heterozygous mice lacking one allele of these receptors. Double-heterozygous nrp2vegfr2 mice develop normally without detectable lymphatic sprouting defects. In contrast, double-heterozygote nrp2vegfr3 mice show a reduction of lymphatic vessel sprouting and decreased lymph vessel branching in adult organs. Thus, interaction between Nrp2 and VEGFR3 mediates proper lymphatic vessel sprouting in response to VEGF-C.
Referral of children to a general anaesthetic dental service in Tayside. (2001)

Dental extractions under general anaesthetic are still a common reason for referral. Referring practitioners frequently provide inadequate information, in addition to under-estimating the treatment required. Alternative forms of anxiety management are available and should be considered for children requiring dental extractions.
Miniaturized gas sensor based on silicon substrate-integrated hollow waveguides (2021)

Gas sensors have wide applications including industrial process control, environment monitoring, safety control, etc. The distribution of these sensors enables data generation for the emerging trend of big data and internet of things. In this work, chip-based non-dispersive infrared (NDIR) gas sensors are demonstrated. Silicon substrate-integrated hollow waveguide (Si-iHWG), which is formed through silicon wafer etching and bonding, is used as optical channel and gas cell. A high sensitivity of 50 ppm for CO2 sensing is demonstrated. The Si-iHWG chip-based sensor with compactness, low cost, versatility, and robustness provides a promising platform for miniaturized gas sensing in various application scenarios.
Synthesis of Nano-Crystalline Gamma-TiAl Materials (2003)

One of the principal problems with nano-crystalline materials is producing them in quantities and sizes large enough for valid mechanical property evaluation. The purpose of this study was to explore an innovative method for producing nano-crystalline gamma-TiAl bulk materials using high energy ball milling and brief secondary processes. Nano-crystalline powder feedstock was produced using a Fritsch P4(TM) vario-planetary ball mill recently installed at NASA-LaRC. The high energy ball milling process employed tungsten carbide tooling (vials and balls) and no process control agents to minimize contamination. In a collaborative effort, two approaches were investigated, namely mechanical alloying of elemental powders and attrition milling of pre-alloyed powders. The objective was to subsequently use RF plasma spray deposition and short cycle vacuum hot pressing in order to effect consolidation while retaining nano-crystalline structure in bulk material. Results and discussion of the work performed to date are presented.
Optimum processing conditions for the maximum crystallization rate of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (2023)

The effect of thermal and shear histories on the crystallization rate of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) was studied. As with other crystalline polymers, the shear history greatly affected the crystallization rate when the shear rate was beyond a critical value, i.e., the inverse of the Rouse relaxation time. Even after the formation of extended chain crystals, spherulite texture was clearly discernable. It grew from certain points on the extended chain crystals. Consequently, a row of spherulites appeared along the flow direction. The resin temperature in the molten state was also significant. When the sample was heated to 170 °C, which is beyond the main melting peak in the differential scanning calorimetry curve, unmolten crystals did not affect the linear viscoelastic properties. They acted as effective nucleating agents for the rest of the polymer during cooling. Therefore, the shear history hardly affected the crystallization rate and the number of spherulites.
A Colorimetric Test to Differentiate Patients Infected with Influenza from COVID‐19 (2021)

Patients infected with SARS-CoV-2 and influenza display similar symptoms, but treatment requirements are different. Clinicians need to accurately distinguish SARS-CoV-2 from influenza to provide appropriate treatment. Here, the authors develope a color-based technique to differentiate between patients infected with SARS-CoV-2 and influenza A using a nucleic acid enzyme-gold nanoparticle (GNP) molecular test requiring minimal equipment. The MNAzyme and GNP probes are designed to be robust to viral mutations. Conserved regions of the viral genomes are targeted, and two MNAzymes are created for each virus. The ability of the system to distinguish between SARS-CoV-2 and influenza A using 79 patient samples is tested. When detecting SARS-CoV-2 positive patients, the clinical sensitivity is 90%, and the specificity is 100%. When detecting influenza A, the clinical sensitivity and specificity are 93% and 100%, respectively. The high clinical performance of the MNAzyme-GNP assay shows that it can be used to help clinicians choose effective treatments.
Simulations of cellulose translocation in the bacterial cellulose synthase suggest a regulatory mechanism for the dimeric structure of cellulose (2016)

The processive cycle of the bacterial cellulose synthase (Bcs) includes the addition of a single glucose moiety to the end of a growing cellulose chain followed by the translocation of the nascent chain across the plasma membrane. The mechanism of this translocation and its precise location within the processive cycle are not well understood. In particular, the molecular details of how a polymer (cellulose) whose basic structural unit is a dimer (cellobiose) can be constructed by adding one monomer (glucose) at a time are yet to be elucidated. Here, we have utilized molecular dynamics simulations and free energy calculations to the shed light on these questions. We find that translocation forward by one glucose unit is quite favorable energetically, giving a free energy stabilization of greater than 10 kcal/mol. In addition, there is only a small barrier to translocation, implying that translocation is <i>not</i> rate limiting within the Bcs processive cycle (given experimental rates for cellulose synthesis <i>in vitro</i>). Perhaps most significantly, our results also indicate that steric constraints at the transmembrane tunnel entrance regulate the dimeric structure of cellulose. Namely, when a glucose molecule is added to the cellulose chain in the same orientation as the acceptor glucose, the terminal glucose freely rotates upon forward motion, thus suggesting a regulatory mechanism for the dimeric structure of cellulose. We characterize both the conserved and non-conserved enzyme-polysaccharide interactions that drive translocation, and find that 20 of the 25 residues that strongly interact with the translocating cellulose chain in the simulations are well conserved, mostly with polar or aromatic side chains. Our results also allow for a dynamical analysis of the role of the so-called `finger helix' in cellulose translocation that has been observed structurally. Taken together, these findings aid in the elucidation of the translocation steps of the Bcs processive cycle and may be widely relevant to polysaccharide synthesizing or degrading enzymes that couple catalysis with chain translocation.
Supplementary Tables S4 from Transcriptomic Profiling of Sequential Tumors from Breast Cancer Patients Provides a Global View of Metastatic Expression Changes Following Endocrine Therapy (2023)

&lt;p&gt;Supplementary Table S4: Patient information for patients A-L&lt;/p&gt;
Curriculum for training in endoscopic mucosal resection in the colon: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement (2023)

Endoscopic mucosal resection (EMR) is the standard of care for the complete removal of large (≥ 10 mm) nonpedunculated colorectal polyps (LNPCPs). Increased detection of LNPCPs owing to screening colonoscopy, plus high observed rates of incomplete resection and need for surgery call for a standardized approach to training in EMR. 1 : Trainees in EMR should have achieved basic competence in diagnostic colonoscopy, < 10-mm polypectomy, pedunculated polypectomy, and common methods of gastrointestinal endoscopic hemostasis. The role of formal training courses is emphasized. Training may then commence in vivo under the direct supervision of a trainer. 2 : Endoscopy units training endoscopists in EMR should have specific processes in place to support and facilitate training. 3: A trained EMR practitioner should have mastered theoretical knowledge including how to assess an LNPCP for risk of submucosal invasion, how to interpret the potential difficulty of a particular EMR procedure, how to decide whether to remove a particular LNPCP en bloc or piecemeal, whether the risks of electrosurgical energy can be avoided for a particular LNPCP, the different devices required for EMR, management of adverse events, and interpretation of reports provided by histopathologists. 4: Trained EMR practitioners should be familiar with the patient consent process for EMR. 5: The development of endoscopic non-technical skills (ENTS) and team interaction are important for trainees in EMR. 6: Differences in recommended technique exist between EMR performed with and without electrosurgical energy. Common to both is a standardized technique based upon dynamic injection, controlled and precise snare placement, safety checks prior to the application of tissue transection (cold snare) or electrosurgical energy (hot snare), and interpretation of the post-EMR resection defect. 7: A trained EMR practitioner must be able to manage adverse events associated with EMR including intraprocedural bleeding and perforation, and post-procedural bleeding. Delayed perforation should be avoided by correct interpretation of the post-EMR defect and treatment of deep mural injury. 8: A trained EMR practitioner must be able to communicate EMR procedural findings to patients and provide them with a plan in case of adverse events after discharge and a follow-up plan. 9: A trained EMR practitioner must be able to detect and interrogate a post-endoscopic resection scar for residual or recurrent adenoma and apply treatment if necessary. 10: Prior to independent practice, a minimum of 30 EMR procedures should be performed, culminating in a trainer-guided assessment of competency using a validated assessment tool, taking account of procedural difficulty (e. g. using the SMSA polyp score). 11: Trained practitioners should log their key performance indicators (KPIs) of polypectomy during independent practice. A guide for target KPIs is provided in this document.
Using Pneumatic Hybrid Technology to Reduce Fuel Consumption and Eliminate Turbo-Lag (2013)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;For the vehicles with frequent stop-start operations, fuel consumption can be reduced significantly by implementing stop-start operation. As one way to realize this goal, the pneumatic hybrid technology converts kinetic energy to pneumatic energy by compressing air into air tanks installed on the vehicle. The compressed air can then be reused to drive an air starter to realize a regenerative stop-start function. Furthermore, the pneumatic hybrid can eliminate turbo-lag by injecting compressed air into manifold and a correspondingly larger amount of fuel into the cylinder to build-up full-load torque almost immediately.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;This paper takes the pneumatic hybrid engine as the research object, focusing on evaluating the improvement of fuel economy of multiple air tanks in different test cycles. Also theoretical analysis the benefits of extra boost on reducing turbo-lag to achieve better performance.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;A six-cylinder pneumatic hybrid diesel engine model is built in the MATLAB/Simulink environment with Stateflow®. Based on this model, a pneumatic hybrid vehicle driving cycle simulation program has been applied to analyze the charging and discharging processes during various bus duty cycles. The analysis shows that the pneumatic hybrid engine can reduce fuel consumption by at least 5% by realizing stop-start operation, and eliminate 90% of the idling time. A new engine concept and structure which can realize the boost engine function has been proposed. The theoretical analysis of this engine is also given out.&lt;/div&gt;&lt;/div&gt;
Regulatory organization of the staphylococcal sae locus (2008)

This paper describes an investigation of the complex internal regulatory circuitry of the staphylococcal sae locus and the impact of modifying this circuitry on the expression of external genes in the sae regulon. The sae locus contains four genes, the saeR and S two-component signalling module (TCS), and saeP and Q, two upstream genes of hitherto unknown function. It is expressed from two promoters, PA sae, which transcribes only the TCS, and PC sae, which transcribes the entire locus. A bursa aurealis (bursa) transposon insertion in saeP in a derivative of Staphylococcus aureus NCTC 8325 has a profound effect on sae function. It modifies the activity of the TCS, changing the expression of many genes in the sae regulon, even though transcription of the TCS (from PA sae) is not interrupted. Moreover, these effects are not due to disruption of saeP since an in-frame deletion in saeP has essentially no phenotype. The phenotype of S. aureus strain Newman is remarkably similar to that of the saeP : : bursa and this similarity is explained by an amino acid substitution in the Newman saeS gene that is predicted to modify profoundly the signalling function of the protein. This concurrence suggests that the saeP : : bursa insertion affects the signalling function of saeS, a suggestion that is supported by the ability of an saeQR clone, but not an saeR clone, to complement the effects of the saeP : : bursa insertion.
Development of cloned pig embryos by nuclear transfer following different activation treatments (2004)

This study compared the effects of activation treatments on the development and ploidy of nuclear transferred (NT) pig embryos. After in vitro maturation of oocytes collected from the slaughterhouse, oocytes were enucleated and reconstructed by transfer of donor cells and fusion with three DC pulses (1.4 kV/cm, 20 musec). Oocytes were pulsed thrice electrically with 1.4 kV/cm for 20 musec and NT eggs were divided into three treatment groups: Group 1 (no further treatment), Group 2 (10 mug/mL cycloheximide [CHX], 3 hr), and Group 3 (1.9 mM 6-dimethylaminopurine [DMAP], 3 hr). All the eggs were cultured in sets of 30 in 60 muL drops of NCSU-23 supplemented with 4 mg/mL fatty acid free BSA, and compared for the rates of development and ploidy. The rates of cleavage, development, and total cell number of parthenotes in Group 3 were significantly (P < 0.05) higher than those in Groups 1 and 2. Cleavage rates of NT embryos in Group 1 were significantly (P < 0.05) lower than those in Groups 2 and 3 (73% vs. 81% and 82%, respectively). Development into blastocyst stage and total cell number of NT embryos in Group 3 were significantly (P < 0.05) higher than those in Groups 1 and 2. Although the embryos in Group 3 had higher development, approximately 58% of NT embryos evaluated were abnormal ploidy (6% haploidy, 9% polyploidy, and 42% mixoploid). The results suggested that although DMAP enhanced development and higher cell number, due attention should be paid to abnormal ploidy in pig NT embryos.
Docosahexaenoic acid is taken up by the inner segment of frog photoreceptors leading to an active synthesis of docosahexaenoyl inositol lipids: similarities in metabolismin vivoandin vitro (1994)

Retinal uptake and metabolism of docosahexaenoic acid (DHA) was studied in vivo in frogs 1, 2, and 6 hours after dorsal lymph sac injections of [3H]-DHA (50 microCi/g). Light microscope autoradiography and biochemical techniques were used to compare the profiles of cellular uptake and lipid labeling with those obtained from 6 hour [3H]-DHA retinal incubations (final DHA concentration, 0.11 and 25 microM). Light microscope autoradiography demonstrated that rod photoreceptor ellipsoids and synaptic terminals preferentially labeled both in vivo and in vitro conditions. Also, the cytoplasm and oil droplets of retinal pigment epithelial cells became very heavily labeled after 6 hours of in vivo labeling. Phosphatidic acid showed the highest labeling in one hour, while other phospholipids accumulated label throughout the 6 hours. At that time point, most label was recovered in phosphatidyl-ethanolamine (37%), phosphatidylcholine (27%), and phosphatidylinositol (16%), the latter displaying 1.6-fold higher labeling than phosphatidylserine. The profile of labeled lipids was similar to that obtained in vitro when the concentration of DHA was in the nanomolar range. Our results suggest that de novo lipid synthesis is a major route for esterification of [3H]-DHA into retinal lipids, giving rise to an early and rapid labeling of DHA-phosphatidylinositol, both in vivo and in vitro, when DHA is present at low concentrations. Furthermore, the profile of labeled retinal cells under in vivo conditions closely resembles in vitro DHA labeling.
Power deposition patterns of interstitial microwave hyperthermia applicators having tapered dielectric sheaths (1998)

A coaxial dipole inserted into a cylindrical dielectric sheath is widely used as an interstitial microwave hyperthermia applicator. A means is described here of controlling the current distribution along the dipole and consequently controlling the distribution of the radiated power density by tapering the outside diameter of the dielectric sheath. Numerical results have been obtained for nylon catheters having three different cross-sections using the theory of linear, insulated antennas embedded in electrically dense media. The inner diameter of the dielectric sheath is the same in the three cases and is equal to the diameter of the conductor. The outer diameter is uniform in case 1, linearly tapered in case 2 and nonlinearly tapered in case 3. Numerical results were obtained at a frequency of 915 MHz, assuming a relative permittivity in the ambient medium of (51–j31), which is typical of tissue having a high water content. The tapers were selected such that the resonant length was the same in the three cases. It was found that the power density close to the tip of the applicator was increased considerably through the use of a linearly tapered sheath, with further improvement being obtained using the nonlinear taper.
Optical performance monitoring to enable robust and reconfigurable optical high-capacity networks (2009)

The desirable features of future optical high-capacity networks include higher stability, reconfigurability and security. In order to enable robust and self-managed automated operation, the network itself should be able to monitor the physical state of the network, automatically diagnose and repair the network, dynamically allocate resources, and redirect traffic. Optical performance monitoring can agilely provide valuable information such that routing tables themselves can dynamically reflect the state of the physical links to the network controller. The key features of the desired monitor include simplicity in implementation, cost-effectiveness, transparency to data formats and rates, and isolation of the specific impairment from the others. We propose and demonstrate novel optical performance monitoring techniques using cost-effective photonic components and artificial neural network-assisted signal processing to continuously monitor multiple impairments and to accommodate different high-speed advanced modulation formats. These monitoring techniques can facilitate rapid identification and isolation of impairments to enhance the dynamic management of the optical high-capacity networks.