gebhart/patrepeval huggingface dataset:
Compressed Tablet (2016)

This Glossary of Terms Related to Pharmaceutics is needed by practitioners in the field of pharmaceutics as this field fulfills an important and crucial role, different from the roles of other scientific disciplines involved in the drugmaking process. The glossary contains 168 definitions used in pharmaceutics. These are related to various aspects of this discipline, such as: (1) physicochemical characterization of pharmaceutical preparations and the active ingredients they contain; (2) unit operations used in the practice of pharmaceutics; (3) terms related to the various dosage forms; (4) terms related to the various modes and routes of drug delivery; (5) terms used in pharmacokinetics and biopharmaceutics in general; and additional miscellaneous terms. The field of pharmaceutics itself is of a multidisciplinary nature as its practitioners come from a variety of disciplines, such as chemistry or various biological sciences, thus a glossary containing authoritative definitions would be useful for them. The terms used in pharmaceutics are rarely covered by existing glossaries, and in the cases they are, their definitions are often inappropriate for the field of pharmaceutics and require new or modified definitions to better fit the new context.
A new partially covered nitinol stent for palliative treatment of malignant bile duct obstruction: a multicenter single-arm prospective study (2011)

This new partially covered nitinol SEMS is easily inserted, and safe and effective in the palliation of biliary obstruction secondary to malignant bile duct strictures.
Towards high efficiency tandem solar cells based on III-V nanowires on silicon (2019)

National audience
Co-localized micro-optical coherence tomography-fluorescence confocal microscopy (µOCT-FCM) (Conference Presentation) (2023)

Micro-Optical Coherence Tomography (μOCT) enables non-invasive, label-free cross-sectional imaging with subcellular resolution and extended depth of focus. However, μOCT provides limited sensitivity and specificity to the molecular and genomic signatures. The combination of µOCT and Fluorescence Confocal Microscopy (FCM) would improve our capability to interrogate biological specimens. We built and characterized a µOCT-FCM that enables colocalized imaging of µOCT and fluorescence signals. Depth scanning in the fluorescence channel was enabled by using an electronically tunable lens. We report the optical design, system-level integration, and characterization, and demonstrate the quantification of pH of airway mucus in a spatially resolved manner in cell cultures and ex-vivo swine tissue.
The RAD (2018)

We introduce the racing auditory display (RAD), an audio-based user interface that allows players who are blind to play the same types of racing games that sighted players can play with an efficiency and sense of control that are similar to what sighted players have. The RAD works with a standard pair of headphones and comprises two novel sonification techniques: the sound slider for understanding a car's speed and trajectory on a racetrack and the turn indicator system for alerting players of the direction, sharpness, length, and timing of upcoming turns. In a user study with 15 participants (3 blind; the rest blindfolded and analyzed separately), we found that players preferred the RAD's interface over that of Mach 1, a popular blind-accessible racing game. We also found that the RAD allows an avid gamer who is blind to race as well on a complex racetrack as casual sighted players can, without a significant difference between lap times or driving paths.
Moderate antiangiogenic activity by local, transgenic expression of endostatin in Rip1Tag2 transgenic mice (2006)

Many previous reports have demonstrated that systemic administration of endostatin (ES), a proteolytic cleavage product of collagen type XVIII and an endogenous angiogenesis inhibitor, represses tumor angiogenesis in different preclinical tumor models with varying efficacy. For example, systemic delivery of recombinant ES to rat insulin promoter 1 (Rip1)T-antigen 2 (Tag2)-transgenic mice, a mouse model of pancreatic beta-cell carcinogenesis, has repressed tumor angiogenesis efficiently and with it, tumor growth. Here, we report that the transgenic expression of ES in Rip1ES-transgenic mice only interferes moderately with tumor growth in Rip1Tag2;Rip1ES double-transgenic mice. Tumor incidence is not reduced by the local expression of ES, and tumor outgrowth and progression to tumor malignancy are only retarded slightly. A significant effect of local ES expression on tumor angiogenesis is only apparent during the early stages of tumor development, where less angiogenic hyperplastic lesions are observed. Although efficiently produced and secreted by transgenic beta cells, locally expressed ES appears to be sequestered in the microenvironment, and its systemic levels are not increased. The results indicate that the antiangiogenic functions of ES critically depend on the mode of delivery and the site of expression: although its systemic application represses tumor angiogenesis and tumor growth efficiently, locally expressed ES appears to be less effective, and hence, additional mechanisms of solubilization or activation of latent ES seem to be required. These results have important implications about the modes of delivery used in antiangiogenic, therapeutic strategies, which are based on the antiangiogenic activities of ES.
Test plan: WIPP Materials Interface Interactions Test (MIIT). [Glass waste forms] (1986)

The WIPP Materials Interface Interactions Test (MIIT) multinational, cooperative, in situ experiments to be replaced in the Waste Isolation Pilot Plant (WIPP) starting in 1986. The MIIT involves the in situ evaluation of various waste package materials interactions in a repository-relevant, brine environment. The predominant emphasis in these tests is (1) to assess the performance.of defense high-level waste glass representative of that to be produced at the Defense Waste Processing Facility (DWPF), and (2) to obtain a fuller understanding of the relative behavior of this glass by comparing it to the behavior of many other high-level and transuranic glass waste forms in an Identical salt repository environment. For the purpose of ed to denote waste glass behavior this Test Plan, the term performance'' is used in the specific environment considered or tested. The tested glass waste forms come from various US and foreign laboratories. This assessment involves the long-term, in situ leaching and surface interactions testing in brine, in boreholes in the WIPP, at 90[degree]C. It is anticipated that segments of the WIPP MIIT will continue for as long as 5 years. All glass waste forms used in this test series are nonradioactive.
ChemInform Abstract: Synthesis of 3‐Alkenylamines, 4‐Alkenylamines and 3‐Allenylamines via a Transamination Procedure. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Unexplained cerebral vasculitis and stroke: keep Lyme neuroborreliosis in mind (2007)

756 http://neurology.thelancet.com Vol 6 September 2007 In their excellent review on Lyme neuroborreliosis, Pachner and Steiner describe various clinical presentations and the potential overlap with other neurological diseases, such as fi bromyalgia. With regard to the rare CNS manifestations of Lyme neuroborreliosis, the authors focus on encephalitis and encephalopathy. However, neurologists should be aware that a small, but important, number of patients with Lyme neuroborreliosis present with a classic neurological emergency that is not mentioned in the review: stroke. Stroke in patients with Lyme neuroborreliosis has many aspects. Patients might present with subarachnoid Unexplained cerebral vasculitis and stroke: keep Lyme neuroborreliosis in mind
Space-Time Encoded MISO Broadcast Channel with Outdated CSIT: An Error\n Rate and Diversity Performance Analysis (2014)

Studies of the MISO Broadcast Channel (BC) with delayed Channel State\nInformation at the Transmitter (CSIT) have so far focused on the sum-rate and\nDegrees-of-Freedom (DoF) region analysis. In this paper, we investigate for the\nfirst time the error rate performance at finite SNR and the\ndiversity-multiplexing tradeoff (DMT) at infinite SNR of a space-time encoded\ntransmission over a two-user MISO BC with delayed CSIT. We consider the\nso-called MAT protocol obtained by Maddah-Ali and Tse, which was shown to\nprovide 33% DoF enhancement over TDMA. While the asymptotic DMT analysis shows\nthat MAT is always preferable to TDMA, the Pairwise Error Probability analysis\nat finite SNR shows that MAT is in fact not always a better alternative to\nTDMA. Benefits can be obtained over TDMA only at very high rate or once\nconcatenated with a full-rate full-diversity space-time code. The analysis is\nalso extended to spatially correlated channels and the influence of transmit\ncorrelation matrices and user pairing strategies on the performance are\ndiscussed. Relying on statistical CSIT, signal constellations are further\noptimized to improve the error rate performance of MAT and make it insensitive\nto user orthogonality. Finally, other transmission strategies relying on\ndelayed CSIT are discussed.\n
Performance of solmacs, a high PV solar concentrator with efficient optics (2012)

A new solar panel with high concentration photovoltaic technology (x700) has been designed, prototyped and tested in the SOLMACS project. The quality of concentrating optics is a key factor for high module efficiency. Therefore new dedicated PMMA Fresnel lenses were studied and produced by injection molding. Lens design, material and production process were optimized to achieve a high optical yield of 86%. Thorough lens performance assessment in optical laboratory was completed with lifetime UV aging tests. Another important aspect is the thermal control of the hot spot created under the solar cell that receives the concentrated flux of 700 Suns. A dedicated heat spreader was developed to achieve passive thermal control with minimum mass and cost. This was supported by thermal models and tests at both cell and module level. 35% triple junction cells were implemented in the module. Micro-assembly technologies were used for the cell packaging and electrical connections. In support to the research, a continuous solar simulator was designed and built to assess the system performance, both at component and module level. The concentrator developments were integrated in a prototype and tested both indoor with the simulator and outdoor on the CSL solar test platform. The overall efficiency of the PV concentrator module is 28.5%.
Self-Organization of Graft Copolymers and Retortable iPP-Based Nanoporous Films Thereof (2022)

Polyolefins might become inexpensive alternatives to the existing membranes based on polyethersulfone. Here, we disclose the production of retortable, well-defined polypropylene (PP)-based nanoporous films derived from amphiphilic graft copolymer precursors. The graft copolymers, containing a polypropylene backbone and polyester grafts, were obtained by grafting lactones, specifically δ-valerolactone and ε-caprolactone, from well-defined randomly functionalized poly(propylene-co-10-undecen-1-ol) as a macroinitiator. Depending on the composition, the graft copolymers self-assemble into droplet, cylindrical, lamellar, or interconnected two-phase morphologies. Functional mesoporous iPP-based films were fabricated by the selective degradation of the polyester blocks of the copolymers. Their structure and morphology were studied using atomic force microscopy (AFM), scanning electron microscopy (SEM), small-angle X-ray scattering (SAXS), and solid-state NMR, while the mesoporosity was assessed by nitrogen sorption experiments. The pore size of the films is strongly influenced not only by the volume fraction of the copolymer blocks but unexpectedly also by the topology (i.e., number of grafts) of the graft copolymer, as was confirmed by computational modeling studies using the dynamic density functional theory (DDFT) engine within the Culgi software. This work provides a conclusive answer on how the morphology of iPP-based graft copolymers is tuned by the copolymer composition and the amount and length of the grafted polyester blocks. Filtration tests and flux determination demonstrated that such structurally well-defined mesoporous products could be considered for the development of ultrafiltration membranes while the chemical resistance and sterilization tests revealed their robust performance and suitability for water purification applications.
Inference of Gene Regulatory Networks with Sparse Structural Equation Models Exploiting Genetic Perturbations (2013)

Integrating genetic perturbations with gene expression data not only improves accuracy of regulatory network topology inference, but also enables learning of causal regulatory relations between genes. Although a number of methods have been developed to integrate both types of data, the desiderata of efficient and powerful algorithms still remains. In this paper, sparse structural equation models (SEMs) are employed to integrate both gene expression data and cis-expression quantitative trait loci (cis-eQTL), for modeling gene regulatory networks in accordance with biological evidence about genes regulating or being regulated by a small number of genes. A systematic inference method named sparsity-aware maximum likelihood (SML) is developed for SEM estimation. Using simulated directed acyclic or cyclic networks, the SML performance is compared with that of two state-of-the-art algorithms: the adaptive Lasso (AL) based scheme, and the QTL-directed dependency graph (QDG) method. Computer simulations demonstrate that the novel SML algorithm offers significantly better performance than the AL-based and QDG algorithms across all sample sizes from 100 to 1,000, in terms of detection power and false discovery rate, in all the cases tested that include acyclic or cyclic networks of 10, 30 and 300 genes. The SML method is further applied to infer a network of 39 human genes that are related to the immune function and are chosen to have a reliable eQTL per gene. The resulting network consists of 9 genes and 13 edges. Most of the edges represent interactions reasonably expected from experimental evidence, while the remaining may just indicate the emergence of new interactions. The sparse SEM and efficient SML algorithm provide an effective means of exploiting both gene expression and perturbation data to infer gene regulatory networks. An open-source computer program implementing the SML algorithm is freely available upon request.
Serial Analysis of Gene Expression in Human Monocytes and Macrophages (1999)

Monocytes/macrophages serve as sentinels involved in chronic inflammation and the eradication of various pathogens. To define molecularly the differentiation of blood monocytes into macrophages, we conducted serial analysis of gene expression (SAGE) in human blood monocytes/macrophages induced by granulocyte-macrophage colony-stimulating factor (GM-CSF) or M-CSF. SAGE analysis of 57,560, 57,463, and 55,856 tags from monocytes, GM-CSF-, and M-CSF-induced macrophages, respectively, allowed identification of 35,037 different transcripts. Interestingly, the genes with the highest expression during differentiation from monocytes into macrophages were genes involved in lipid metabolism. Both CSF-induced macrophages expressed similar sets of genes except for several genes such as monocyte-derived chemokine (MDC), legumain, prostaglandin D synthetase, and lysosomal sialoglycoprotein. The identification of specific gene expression in human monocytes, GM-CSF-, or M-CSF-induced macrophages provides novel methods to define macrophage subsets and the maturation and activation stage of cells of macrophage lineage and, possibly, to diagnose diseases in which macrophages play a major role. This study represents the first extensive serial analysis of gene expression for any type of human hematopoietic cells.
Chemical kinetics of the NH/sub 3//NO reaction system under combustion exhaust-flow conditions (1980)

Quantitative understanding of the NH/sub i/NO/sub x/ reaction system is necessary to optimize the homogeneous removal of exhaust flow nitric oxide by ammonia addition and to minimize the formation of NO/sub x/ from fuel nitrogen. Attempts to model this chemistry have been hampered by a lack of high temperature rate constant and product branching ratio data for key reactions. Utilizing a unique high temperature flow facility, the rate constants for important initiation and propagation steps for the NH/sub i/NO/sub x/ reaction system have been measured over the temperature range 294 to 1200/sup 0/K. Product branching results have been incorporated into a chemical model which describes the salient features of the NO/sub i/NO/sub x/ reaction system. The application of the model in predicting the behavior of NO in combustor exhaust flows upon addition of ammonia is presented.
Electron Beam Deposition of Ti 6-4 for Aerospace Structures (2007)

[Abstract] Boeing Phantom Works has initiated a studies of Electron Beam Deposition of Titanium 6Al -4V for the fabrication of aircraft and spacecraft structure and mechanisms. This technique involves the melting of Ti 6 -4 material in a vacuum and solidifying it to form engineered shapes. Boe ing has evaluated two deposition methods and materials, namely low power, powder based and higher power, wire based. Each of these systems has applications for aircraft and spacecraft. The purpose of this paper is to report the results of mechanical testin g of the higher power, wire based method. This testing was undertaken to qualify this process for the production of flight worthy, production parts. In general, for a given set of welding parameters, this process were found to yield mechanical properties s imilar to the parent material. This paper will detail these results . I. Background
34.3: A Novel Charge‐Shared S‐PVA Technology (2007)

Abstract A charge‐shared super patterned‐ITO vertical alignment (CS S‐PVA) LCD mode is proposed. CS S‐PVA controls the voltage ratio between two sub‐pixels by a unique charge‐sharing topology, resulting in improved off‐axis image quality and transmittance increase without any side effects. Moreover, the new S‐PVA LCD mode is free of image‐sticking. Operating schemes and display performance of CS S‐PVA are presented.
Multiscale Modeling of Hepatitis B Virus Capsid Assembly and its Dimorphism (2022)

Hepatitis B Virus (HBV) is an endemic, chronic virus that leads to 800,000 deaths per year. Central to the HBV lifecycle, the viral core has a protein capsid assembled from many copies of a single protein. The capsid protein adopts different (quasi-equivalent) conformations to form icosahedral capsids containing 180 or 240 proteins, T =3 or T =4 respectively in Caspar-Klug nomenclature. HBV capsid assembly has become an important target for new antivirals; nonetheless the assembly pathways and mechanisms that control HBV dimorphism remain unclear. We describe computer simulations of HBV assembly, using a coarse-grained model that has parameters learned from all-atom molecular dynamics simulations of a complete HBV capsid, and yet is computationally tractable. Dynamical simulations with the resulting model reproduce experimental observations of HBV assembly pathways and products. By constructing Markov state models and employing transition path theory, we identify pathways leading to T =3, T =4, and other experimentally observed capsid morphologies. The analysis identifies factors that control this polymorphism, in particular, the conformational free energy landscape of the capsid proteins and their interactions.
Metal-promoted nucleophilic addition of water to coordinated 2,3-bis(2-pyridyl)benzoquinoxaline in rhenium(V) complexes. Crystal structure of the hydration product ReOCl2(C22H15N4O) (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetal-promoted nucleophilic addition of water to coordinated 2,3-bis(2-pyridyl)benzoquinoxaline in rhenium(V) complexes. Crystal structure of the hydration product ReOCl2(C22H15N4O)Guiliano Bandoli, T. I. A. Gerber, R. Jacobs, and J. G. H. du PreezCite this: Inorg. Chem. 1994, 33, 1, 178–179Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/ic00079a032https://doi.org/10.1021/ic00079a032research-articleACS PublicationsRequest reuse permissionsArticle Views88Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Dual-Erp Representation for Object Detection in 360° Images (2022)

Object detection has achieved good performance on perspective images. However, a general object detector does not maintain this performance when applied to a 360° image in a single equirectangular projection (ERP) or multi-projection representation because of the distortion in the high-latitude region or discontinuity at the boundaries. In this paper, we proposed dual-ERP, which is a multi-view ERP representation, as the network input for 360° object detection in training and inference. Dual-ERP combines the advantages of single ERP and multi-projection representations, and it can easily be integrated with existing object detectors. The experimental results showed that compared to other representations, dual-ERP significantly improved the performance of different baseline object detectors.
A novel SPICE macromodel of BJTs including the temperature dependence of high-injection effects (2004)

In this work a novel steady-state ABM-based BJT macromodel is presented, which can be successfully adopted for accurately describing the electrothermal behavior of devices consisting of several elementary transistors connected in parallel. As an enhancement with respect to other approaches, the temperature dependence of the onset of high-injection effects is taken into account, which implies a complete description of possible electrothermal stabilizing mechanisms at high-current regimes.
Reliability of the nonalcoholic steatohepatitis clinical research network and steatosis activity fibrosis histological scoring systems (2022)

These findings do not support the direct inter-translation between the NASH CRN and the SAF. However, the diagnosis of NASH during examinations using the NASH CRN may be comparable with diagnosis of NASH using the SAF, vice versa. The inter-observer agreement for lobular inflammation and NASH diagnosis needs to be improved.
ChemInform Abstract: Safety Assessment of Nanomaterials Using Toxicokinetics and Toxicoproteome Analysis (2010)

Abstract Review: 17 refs.