gebhart/patrepeval huggingface dataset:
An Efficient, Single-Source Molecular Precursor to Silicoaluminophosphates (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTAn Efficient, Single-Source Molecular Precursor to SilicoaluminophosphatesKyle L. Fujdala and T. Don TilleyView Author Information Department of Chemistry University of California, Berkeley Berkeley, California 94720-1460 Chemical Sciences Division Lawrence Berkeley Laboratory 1 Cyclotron Road, Berkeley, California 94720 Cite this: J. Am. Chem. Soc. 2001, 123, 41, 10133–10134Publication Date (Web):September 19, 2001Publication History Received30 July 2001Published online19 September 2001Published inissue 1 October 2001https://pubs.acs.org/doi/10.1021/ja0167295https://doi.org/10.1021/ja0167295rapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views1222Altmetric-Citations99LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Aromatic compounds,Hydrocarbons,Materials,Organic reactions,Precursors Get e-Alerts
Epidemic thresholds with external agents (2014)

We study the effect of external infection sources on phase transitions in epidemic processes. In particular, we consider an epidemic spreading on a network via the SIS/SIR dynamics, which in addition is aided by external agents - sources unconstrained by the graph, but possessing a limited infection rate or virulence. Such a model captures many existing models of externally aided epidemics, and finds use in many settings - epidemiology, marketing and advertising, network robustness, etc. We provide a detailed characterization of the impact of external agents on epidemic thresholds. In particular, for the SIS model, we show that any external infection strategy with constant virulence either fails to significantly affect the lifetime of an epidemic, or at best, sustains the epidemic for a lifetime which is polynomial in the number of nodes. On the other hand, a random external-infection strategy, with rate increasing linearly in the number of infected nodes, succeeds under some conditions to sustain an exponential epidemic lifetime. We obtain similar sharp thresholds for the SIR model, and discuss the relevance of our results in a variety of settings.
Acylation Type Determines Ghrelin's Effects on Energy Homeostasis in Rodents (2012)

Ghrelin is a gastrointestinal polypeptide that acts through the ghrelin receptor (GHSR) to promote food intake and increase adiposity. Activation of GHSR requires the presence of a fatty-acid (FA) side chain on amino acid residue serine 3 of the ghrelin molecule. However, little is known about the role that the type of FA used for acylation plays in the biological action of ghrelin. We therefore evaluated a series of differentially acylated peptides to determine whether alterations in length or stability of the FA side chain have an impact on the ability of ghrelin to activate GHSR in vitro or to differentially alter food intake, body weight, and body composition in vivo. Fatty acids principally available in the diet (such as palmitate C16) and therefore representing potential substrates for the ghrelin-activating enzyme ghrelin O-acyltransferase (GOAT) were used for dose-, time-, and administration/route-dependent effects of ghrelin on food intake, body weight, and body composition in rats and mice. Our data demonstrate that altering the length of the FA side chain of ghrelin results in the differential activation of GHSR. Additionally, we found that acylation of ghrelin with a long-chain FA (C16) delays the acute central stimulation of food intake. Lastly, we found that, depending on acylation length, systemic and central chronic actions of ghrelin on adiposity can be enhanced or reduced. Together our data suggest that modification of the FA side-chain length can be a novel approach to modulate the efficacy of pharmacologically administered ghrelin.
In Planta Labeling Using a Clickable ER-Disrupting Probe Suggests a Role for Oleosins in Arabidopsis Seedling ER Integrity (2021)

Several small-molecule perturbagens of the plant endomembrane system are known, but few selectively disrupt endoplasmic reticulum (ER) structure and function. We conducted a microscopy-based screen for small-molecule disruptors of ER structure and discovered eroonazole, a 1,2-4-triazole that induces extensive ER vesiculation in <i>Arabidopsis</i> seedlings. To identify eroonazole targets, we synthesized a clickable photoaffinity derivative and used it for whole-seedling labeling experiments. These reveal that the probe labels multiple oleosins, plant membrane proteins that stabilize ER-derived lipid droplets. Oleosin labeling is absent in an <i>oleosin1234</i> quadruple mutant and reduced using an inactive analog. Cellular analyses of the ER in the quadruple mutant demonstrate that oleosins are required for normal ER structure during seed germination and suggest that perturbation of oleosin function by eroonazole underlies its effects on seedling ER structure.
P336 Association between the prior duration of remission and efficacy outcomes in patients with Ulcerative Colitis treated with tofacitinib 10 mg twice daily who were in stable remission and either dose-reduced to tofacitinib 5 mg twice daily or remained on 10 mg twice daily: 6-month data from the double-blind, randomised RIVETING study (2021)

Abstract Background Tofacitinib is an oral, small molecule JAK inhibitor for the treatment of ulcerative colitis (UC). RIVETING (NCT03281304) is an ongoing, double-blind, randomised, parallel-group study designed to evaluate the efficacy and safety of dose reduction to tofacitinib 5 mg twice daily (BID) vs remaining on 10 mg BID in patients (pts) with UC in stable remission on tofacitinib 10 mg BID maintenance therapy. Eligible pts had received tofacitinib 10 mg BID for ≥2 consecutive years in an open-label, long-term extension study (NCT01470612), and had been in stable remission for ≥6 months (M) and corticosteroid-free for ≥4 weeks prior to enrolment.1 We aimed to evaluate the association between the duration of remission prior to enrolment into RIVETING and the efficacy of tofacitinib 5 and 10 mg BID. Methods Pts who were in partial Mayo score (PMS) remission (a PMS of ≤2 with no individual subscore &amp;gt;1, and a rectal bleeding subscore of 0) at RIVETING baseline were included in this analysis. Pts were randomised to dose-reduce to tofacitinib 5 mg BID or remain on 10 mg BID. We evaluated efficacy endpoints at Month 6 in RIVETING, stratified by duration of PMS remission (0–12, 12–24, 24–36, 36–48, &amp;gt;48 M) at RIVETING baseline. Results At RIVETING baseline, 139 of 140 pts were in PMS remission: 69 pts dose-reduced to tofacitinib 5 mg BID and 70 pts remained on tofacitinib 10 mg BID. In both treatment groups, compared with pts with &amp;lt;24M of PMS remission, baseline modified Mayo and total Mayo scores were numerically lower in pts with a PMS remission duration of &amp;gt;24M; these pts also generally had a numerically lower change from baseline modified Mayo and total Mayo scores at Month 6 (Table). At Month 6, following dose reduction to tofacitinib 5 mg BID, PMS remission was maintained in 66.7%, 60.0%, 82.4%, 75.0% and 90.0% of pts with baseline PMS remission durations of 0–12M, 12–24M, 24–36M, 36–48M and &amp;gt;48M, respectively. Corresponding values for pts who continued to receive tofacitinib 10 mg BID were 80.0%, 88.9%, 91.7%, 100.0% and 100.0%. At Month 6, the proportion of pts achieving modified Mayo remission, remission and modified PMS remission was generally higher in pts with baseline PMS remission of &amp;gt;24M vs pts with PMS remission of &amp;lt;24M across treatment groups (Table). Conclusion Following dose reduction from tofacitinib 10 to 5 mg BID, rates of modified Mayo remission, remission and PMS remission were numerically higher in pts with a PMS remission duration of &amp;gt;24M vs pts with &amp;lt;24M of PMS remission duration. The same trend was observed in pts who continued to receive tofacitinib 10 mg BID. These analyses are post hoc and limited by the small sample size. Reference
Nonlinear Diamond Photonics (2015)

Owing to its wide bandgap, large linear and nonlinear refractive index, diamond is well suited for applications in nonlinear and high-power photonics. I will present our work on on-chip diamond frequency combs and Raman lasers.
Introduction (2008)

Abstract This introductory chapter begins with a discussion of the use of the term ‘vague’ in philosophy. It presents three characteristics of vague predicates: they give rise to borderline cases; their extensions have blurry boundaries; and they generate Sorites paradoxes. It then explains the goal of studying of vagueness, which is gain an account of the semantics of vague predicates — an account of what the meaning of such a predicate consists in, and of how (if at all) it differs from the meaning of a precise predicate. An overview of the subsequent chapters is presented.
8.5-GHz pulse-shape control with a 700:1 Dynamic range on a frequency-tripled multiterawatt solid-state laser (2006)

Precise control of new pulse shapes on the OMEGA laser requires 8.5-GHz, 740:1 dynamic-range measurements at the low-energy front end of the system. We present a new integrated measurement and prediction scheme that meets these demands.
An active audition framework for auditory-driven HRI: Application to interactive robot dancing (2012)

In this paper we propose a general active audition framework for auditory-driven Human-Robot Interaction (HRI). The proposed framework simultaneously processes speech and music on-the-fly, integrates perceptual models for robot audition, and supports verbal and non-verbal interactive communication by means of (pro)active behaviors. To ensure a reliable interaction, on top of the framework a behavior decision mechanism based on active audition policies the robot's actions according to the reliability of the acoustic signals for auditory processing. To validate the framework's application to general auditory-driven HRI, we propose the implementation of an interactive robot dancing system. This system integrates three preprocessing robot audition modules: sound source localization, sound source separation, and ego noise suppression; two modules for auditory perception: live audio beat tracking and automatic speech recognition; and multi-modal behaviors for verbal and non-verbal interaction: music-driven dancing and speech-driven dialoguing. To fully assess the system, we set up experimental and interactive real-world scenarios with highly dynamic acoustic conditions, and defined a set of evaluation criteria. The experimental tests revealed accurate and robust beat tracking and speech recognition, and convincing dance beat-synchrony. The interactive sessions confirmed the fundamental role of the behavior decision mechanism for actively maintaining a robust and natural human-robot interaction.
Iterative Approaches To Computer-Generated Holography (1989)

Two iterative algorithms for synthesis of binary computer-generated holograms (CGHs) for image reconstruction are described: alternating projections onto constraint sets (POCS) and direct binary search (DBS). Comparisons with conventional methods for CGH synthesis show that POCS and DBS yield substantially lower mean-squared reconstruction error and higher diffraction efficiency. The best method is DBS, but it is also the most computationally intensive. To ameliorate this disadvantage, an acceleration technique is presented for DBS. With this technique, the design of binary holograms with moderate space-bandwidth product becomes feasible. For example, the computation required to design a hologram with 256K elements is reduced by a factor of 121.
Effects of recombinant granulocyte-macrophage colony-stimulating factor on bovine peripheral blood and mammary gland neutrophil function in vitro. (1992)

Modulation of peripheral blood and mammary gland neutrophil function following in vitro exposure to recombinant bovine granulocyte-macrophage colony-stimulating factor (rBoGM-CSF) was studied. Bovine blood and mammary gland neutrophils were cultured for 9 h in media containing 0.005, 0.05 or 0.5 microgram/mL rBoGM-CSF. Neutrophils treated with rBoGM-CSF exhibited significantly more chemotactic and bactericidal activities and tended to produce more superoxide anion than control cells. The effects of rBoGM-CSF on bovine neutrophil populations appeared to be dose-dependent. The production of superoxide anion and the bactericidal activity of mammary gland neutrophils were consistently higher than blood neutrophils. Only moderate increases in lipopolysaccharide-induced mammary gland neutrophil functions were observed following incubation with rBoGM-CSF which suggests that there may be a threshold of immunomodulation for these prestimulated cells. It may be possible to augment the functional capacity of bovine neutrophil populations in vivo through the therapeutic application of rBoGM-CSF and consequently enhance resistance of dairy cattle to bacterial infections.
Structure of a zirconoxyborane having a zirconium-fluorine-carbon bridge (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure of a zirconoxyborane having a zirconium-fluorine-carbon bridgeA. R. Siedle, R. A. Newmark, W. M. Lamanna, and J. C. HuffmanCite this: Organometallics 1993, 12, 5, 1491–1492Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/om00029a002https://doi.org/10.1021/om00029a002research-articleACS PublicationsRequest reuse permissionsArticle Views417Altmetric-Citations100LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
PIM1 kinase promotes gallbladder cancer cell proliferation via inhibition of proline-rich Akt substrate of 40 kDa (PRAS40) (2019)

Gallbladder cancer (GBC) is a rare malignancy, associated with poor disease prognosis with a 5-year survival of only 20%. This has been attributed to late presentation of the disease, lack of early diagnostic markers and limited efficacy of therapeutic interventions. Elucidation of molecular events in GBC can contribute to better management of the disease by aiding in the identification of therapeutic targets. To identify aberrantly activated signaling events in GBC, tandem mass tag-based quantitative phosphoproteomic analysis of five GBC cell lines was carried out. Proline-rich Akt substrate 40 kDa (PRAS40) was one of the proteins found to be hyperphosphorylated in all the invasive GBC cell lines. Tissue microarray-based immunohistochemical labeling of phospho-PRAS40 (T246) revealed moderate to strong staining in 77% of the primary gallbladder adenocarcinoma cases. Regulation of PRAS40 activity by inhibiting its upstream kinase PIM1 resulted in a significant decrease in cell proliferation, colony forming and invasive ability of GBC cells. Our results support the role of PRAS40 phosphorylation in GBC cell survival and aggressiveness. This study also elucidates phospho-PRAS40 as a clinical marker in GBC and the role of PIM1 as a therapeutic target in GBC.
Prices and Portfolio Choices in Financial Markets: Theory, Econometrics, Experiments (2007)

Many tests of asset-pricing models address only the pricing predictions, but these pricing predictions rest on portfolio choice predictions that seem obviously wrong. This paper suggests a new approach to asset pricing and portfolio choices based on unobserved heterogeneity. This approach yields the standard pricing conclusions of classical models but is consistent with very different portfolio choices. Novel econometric tests link the price and portfolio predictions and take into account the general equilibrium effects of sample-size bias. This paper works through the approach in detail for the case of the classical capital asset pricing model (CAPM), producing a model called CAPM+?. When these econometric tests are applied to data generated by large-scale laboratory asset markets that reveal both prices and portfolio choices, CAPM+?is not rejected. Â© The Econometric Society 2007.
A black gauze cap-shaped bistable energy harvester with a movable design for broadening frequency bandwidth (2019)

Abstract A black gauze cap-shaped bistable energy harvester (abbreviated as the BGCBEH) with a movable design is raised to broaden frequency bandwidth. The proposed BGCBEH is composed of two harvesting units which like the ancient Chinese cap wings. Under lower frequency vibrations, they can not only reciprocate in the horizontal direction, but also vibrate in the vertical direction. Each harvesting unit can realize adaptive potential by reciprocating sliding of cap wings, and achieving inter-well oscillation to get more energy, which are verified by theoretical analyzing and numerical simulating. Under harmonic excitation, the energy obtained by BGCBEH is greater than that by unmovable bistable energy harvester (abbreviated as the UBEH) within 69.7% of the given frequency bandwidth. The energy acquisition frequency domain is broadened by 373.8% and the corresponding rms voltage is increased by 81%. Under random excitation, the rms voltage of the proposed BGCBEH is increased by 396.4% compared to that of the UBEH. The proposed design is further verified by the experiments. Under harmonic excitation, the energy obtained by BGCBEH is greater than that by the UBEH within 71% of the given frequency bandwidth. The energy acquisition frequency domain is broadened by 44% and the corresponding rms voltage is increased by 111.1%. Under random excitation, the rms voltage of the proposed BGCBEH is increased by 81.7% compared to that of the UBEH, and this increase is distributed over the entire frequency domain. The experimental results are greatly consistent with those observed in the above numerical simulating. The output can be further improved when the sum of movable distance and initial magnetic spacing are optimized. The proposed BGCBEH is expected to be applicable to the early-stage warning and accurate detection of passive acceleration due to its snap-through amplitude response characteristics, which needs to be further explored.
A time domain approach for the fluctuation analysis of heart rate related to instantaneous lung volume (1993)

This paper presents a time domain technique for estimating transfer characteristics from fluctuations of instantaneous lung volume (ILV) to heart rate (HR). An effective procedure for estimating the impulse response of HR to ILV is proposed. Pre- and post-processing procedures, including prefiltering of the HR signal, preenhancement of the high frequency content of the ILV signal, and post-filtering of the estimated impulse response, together with a random breathing technique, are shown to effectively reduce spurious transfer gain so as to get a stable estimate of the impulse response. Analysis of the data collected from fourteen healthy male subjects in various conditions revealed that there are three components in the impulse response: fast positive, delayed slow negative, and oscillatory. The effects of the autonomic blocking agents propranolol and atropine on these transfer characteristics are also described.
Evidence for the Rare Decay Σ+→pμ+μ− (2018)

A search for the rare decay Σ^{+}→pμ^{+}μ^{-} is performed using pp collision data recorded by the LHCb experiment at center-of-mass energies sqrt[s]=7 and 8 TeV, corresponding to an integrated luminosity of 3 fb^{-1}. An excess of events is observed with respect to the background expectation, with a signal significance of 4.1 standard deviations. No significant structure is observed in the dimuon invariant mass distribution, in contrast with a previous result from the HyperCP experiment. The measured Σ^{+}→pμ^{+}μ^{-} branching fraction is (2.2_{-1.3}^{+1.8})×10^{-8}, where statistical and systematic uncertainties are included, which is consistent with the standard model prediction.
Elasticity imaging with time-resolved pulsed elastography (2001)

Time-resolved pulsed elastography is a promising technique for imaging the shear modulus of soft tissues. It is based on the investigation of a low-frequency transient shear wave using an ultrafast ultrasonic imaging system (up to 10&amp;lt;th&amp;gt;000 frames/s) composed of 128 channels sampled at 50 MHz and having 2 Mbytes. The system is connected to a linear array of transducers. Displacements induced by the propagating shear wave are measured using cross correlation of the ultrasonic signals. A low-frequency vibrating device was designed. The linear array of transducers is placed between two rods fixed to electromagnetic vibrators. The rods are either orthogonal or parallel to the active surface of the transducer array. The low-frequency shear waves are sent using the rods which are placed in such a way that the lobes of the induced shear waves superimpose in front of the transducer array. Large displacements are observed in the tissues which makes deeper investigations possible. Movies of the low-frequency (50–200 Hz) shear wave propagation through soft tissues can be used either to estimate the shear modulus distribution in the medium by direct local inversion, or to localize visually lesions of unexpected elasticity. In vivo measurements in human breast will be presented and discussed.
Intracellular Accumulation of T-Cell Receptor Complex Molecules in a Human T-Cell Line (1986)

This work was aimed at understanding the mechanisms of T-lymphocyte function by studying the cellular distribution and traffic of molecules of the T-cell receptor complex. The accumulation of specific molecules in intracytoplasmic vesicles is related to the activation of T lymphocytes. Some of these molecules include acid hydrolases, the transferrin receptor, and class I antigens of the major histocompatibility complex. Molecules of the T-cell receptor complex have now also been found in intracytoplasmic vesicles in a human T-cell line derived from a lymphoblastic leukemia. Such vesicles were tightly associated with the cytoplasmic microtubule network. One functional aspect of this association is a cellular pathway by which vesicles traveling to and from the cell surface converge in an area of the cells that is rich in processing enzymes.