gebhart/patrepeval huggingface dataset:
Low Loss CMOS-Compatible PECVD Silicon Nitride Waveguides and Grating Couplers for Blue Light Optogenetic Applications (2016)

This paper presents silicon nitride (SixNy) photonic integrated circuits (PICs) with high performance at a wavelength of 450 nm, which, therefore, is suitable for neuronal stimulation with optogenetics. These PICs consist of straight and bent waveguides, and grating couplers that are fabricated in a complementary metal-oxide-semiconductor (CMOS)-compatible plasma enhanced chemical vapor deposition SixNy platform. Their characterization shows propagation losses of 0.96 $\pm$ 0.4 dB/cm on average for straight waveguides that are 1-5 $\mu$m wide and bend insertion losses as low as 0.2 dB/90 $^\circ$ for 1 $\mu$m wide waveguides with a radius of 100 $\mu$m. Additionally, the grating coupler characterization shows that they can deliver about 10 $\mu$W of light in an area of 5 $\times$ 9 $\mu$m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> (240 mW/mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ), which is captured from an uncollimated laser diode (70 mW). Besides delivering sufficient power for optogenetic applications, the gratings have dimensions that are comparable to the size of a neuron, which would allow single cell interaction. These results demonstrate that, with this SixNy platform, high-density and large-scale implantable neural devices can be fabricated and readily integrated into existing CMOS-compatible neuro-electronic platforms.
Detection of Connective Tissue Growth Factor in Human Aqueous Humor (2002)

CTGF is present in a majority of AH samples, possibly representing a constant component in this fluid. The origin and physiological importance of CTGF is yet unclear. The involvement of CTGF in processes of intraocular fibrosis and wound healing is possible.
Valosin-Containing Protein Gene Mutations: Cellular Phenotypes Relevant to Neurodegeneration (2011)

Previously, we identified valosin-containing protein (VCP) as a mediator of ER stress-induced cell death. Mutations in the VCP gene including R93, R155, and R191 have been described that manifest clinically as hereditary inclusion body myopathy with Paget's disease of bone and frontotemporal dementia. In addition, other studies have demonstrated that as a consequence of a mutation generated in the second ATP binding domain of VCP (K524A), cells accumulated large cytoplasmic vacuoles and underwent programmed cell death. In order to better understand the biochemical and molecular consequences of the clinically relevant VCP mutations as well as the genetically engineered ATPase-inactive mutant K524A and any relationship these may have to ER stress-induced cell death, we introduced analogous mutations separately and together into the human VCP gene and evaluated their effect on proteasome activity, Huntingtin protein aggregation and ER stress-induced cell death. Our results indicate that the VCP K524A mutant and the triple mutant VCP R93C-R155C-K524A block protein degradation, trigger Huntingtin aggregate formation, and render cells highly susceptible to ER stress-induced cell death as compared to VCPWT or other VCP mutants.
Analytical synthesis of robust controllers of the given accuracy under external perturbations (2016)

An approach that allows finding a set of robust statistic feedback controllers that ensure the given control accuracy for the controlled parameters in a multiconnected control system under bounded parametric and external perturbations of various classes is proposed. To describe the set of controllers of the given accuracy, the results of analytically solving the matrix equations based on matrix canonization and parametrization of the Lyapunov equation are used. The solvability conditions of the synthesis problem ensure the robustness and optimal suppression of the perturbations. They are homogeneously represented as linear matrix inequalities obtained based on the Lyapunov functions. A methodological example is given.
Proton Transfer Polymerization in the Preparation of Hyperbranched Polyesters with Epoxide Chain-Ends and Internal Hydroxyl Functionalities (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTProton Transfer Polymerization in the Preparation of Hyperbranched Polyesters with Epoxide Chain-Ends and Internal Hydroxyl FunctionalitiesCaiguo Gong and Jean M. J. FréchetView Author Information Department of Chemistry, University of California, Berkeley, California 94720-1460 Cite this: Macromolecules 2000, 33, 14, 4997–4999Publication Date (Web):June 22, 2000Publication History Received27 March 2000Revised25 May 2000Published online22 June 2000Published inissue 1 July 2000https://pubs.acs.org/doi/10.1021/ma000538phttps://doi.org/10.1021/ma000538prapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views734Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Anions,Monomers,Organic polymers,Polymerization,Polymers Get e-Alerts
Principal Component Analysis-based compensation for measurement errors due to mechanical misalignments in PCB testing (2010)

Capacitive Leadframe Testing is capable of detecting open solder defects in Printed Circuit Boards (PCB). Principal Component Analysis (PCA)-based approach has been shown to be effective in identifying outlier devices using Capacitive Leadframe Testing measurements. In practice, when a sense plate orientation is shifted or tilted, the resulting measurement variation makes detecting outliers harder. Approaches are introduced to compensate for the `abnormal' measurements due to sense-plate variations. A PCA based technique is developed to estimate the relative amount of tilt and shift in sense plates. Such estimates can be used to compensate for mechanical misalignments. It can also isolate the misalignment related information from the defect related information in the data. The effectiveness of this technique in the presence of the two common forms of mechanical variations is illustrated using experimental measurements from a laboratory setting. The approach is not sensitive to the order of pins, and as such, shows promise for detection of complex but systematic errors introduced by sense plate misalignments.
[The role of circulating immune complexes in pregnancy (author's transl)]. (1981)

The circulating immune complexes in pregnancy sera have been thought to act immunosuppressively to maternal lymphoid system, and to be one of the cause of toxemia of pregnancy. We detected circulating immune complexes in human pregnancy sera using Raji cell test and polyethylene glycol precipitation. We evaluated the correlation between the titers of immune complexes and inhibition rate of lymphocyte blastogenic responses to PHA as well as Con A. There were significant positive correlation (p less than 0.01, p less than 0.02, respectively). Moreover, we also evaluate the correlation between immune complexes and clinical symptoms of toxemia of pregnancy in items of Gestosis Index. There was no significant correlation at the time of sampling, but highly significant correlation was obtained at the time of admission for labor. The differences of Gestosis Indexes at the time of blood sampling and admission for labor were highly significant in the group of high immune complex titer. The cases of toxemia of pregnancy were found that immune complex increased before the symptoms of toxemia of pregnancy appeared. These results suggest that circulating immune complexes in pregnancy have the role of immunosuppression and act as one of the cause of toxemia of pregnancy.
Oxidation of 4‐bromophenol by the recombinant fused protein cellulose‐binding domain‐horseradish peroxidase immobilized on cellulose (2003)

A fused protein consisting of cellulose-binding domain (CBD) and horseradish peroxidase (HRP) was constructed and expressed in Escherichia coli. Refolded recombinant CBD-HRP (95% recovery yield) was bound to microcrystalline cellulose and applied for the oxidation of a model toxic phenol, 4-bromophenol (BP). Oxidation of BP by CBD-HRP resulted in the formation of dimers to pentamers as evidenced by mass spectrometry analysis. When immobilized, the vast majority of the oxidation products adsorbed to the cellulose matrix. CBD-HRP (0.75 pyrogallol units) bound to 0.1 g cellulose was packed in a column, connected to an HPLC pump and monitoring system, and column performance and capacity were studied under various operating conditions. When performance was studied as a function of BP loading rate at a constant H(2)O(2) loading rate of 1500 nmol/min, V(app) (max) and K(m) (app) were calculated to be 5.29 +/- 0.46 micromol mL min and 644.9 +/- 114.3 microM, respectively. Immobilized CBD-HRP exhibited enhanced stability to H(2)O(2) and oxidized considerably more BP than free CBD-HRP. Inclusion of gelatin, which suppresses product-dependent inactivation, further increased the amount of BP oxidation. These findings may have potential impact in terms of enzyme supply in high-rate treatment of wastewater contaminated with toxic phenols, since the susceptibility of peroxidases to both H(2)O(2) - and product-dependent inactivation demands continuous supply of fresh enzyme.
Cross-polarized angular emission patterns from lens-coupled terahertz antennas (2001)

We report detailed measurements of the cross-polarized radiation from lens-coupled terahertz dipole antennas, of the sort commonly used in terahertz time-domain spectroscopy. We compare two different antenna geometries and measure both polarization components as a function of emission angle. The qualitative features of these patterns are not specific to one particular emitter geometry but appear to be generally characteristic of these lens-coupled systems. These measurements are used to determine the angle-dependent ellipticity of the emitted terahertz beam. We conclude that a low f-number collection system (≲f/5) unavoidably results in a beam with a small but measurable ellipticity. This has important implications for any measurements in which a purely linearly polarized wave is required.
Titanium surface modification leading to increased antibacterial ability, bioactivity and biocompatibility (2016)

IntroductionBacterial biofilms can adhere to implants, and may ultimately lead to implant failure. One way to prevent bacterial biofilm formation is to modify the surface to make it antibacterial o ...
Coulomb explosions of molecules in intense laser radiation (1989)

The H2 molecule has recently been studied by a number of groups using resonantly enhanced multiphoton ionization by multicolor narrowband tunable radiation. Early studies measured the yield of various ion species. Current studies monitor the ion fragments and analyze their kinetic energies. Our results show a tall in the kinetic energy distribution of H+ fragments with energies in the 9.8–12.5-eV range and an abundance of ~2% of the total yield. These ions were not observed in experiments using shorter laser pulses and time-of-flight detection systems.
Suppression of tumor growth and cell proliferation by p13 II , a mitochondrial protein of human T cell leukemia virus type 1 (2004)

Human T cell leukemia virus type 1 encodes an "accessory" protein named p13(II) that is targeted to mitochondria and triggers a rapid flux of K(+) and Ca(2+) across the inner membrane. In this study, we investigated the effects of p13(II) on tumorigenicity in vivo and on cell growth in vitro. Results showed that p13(II) significantly reduced the incidence and growth rate of tumors arising from c-myc and Ha-ras-cotransfected rat embryo fibroblasts. Consistent with these findings, HeLa-derived cell lines stably expressing p13(II) exhibited markedly reduced tumorigenicity, as well as reduced proliferation at high density in vitro. Mixed culture assays revealed that the phenotype of the p13(II) cell lines was dominant over that of control lines and was mediated by a heat-labile soluble factor. The p13(II) cell lines exhibited an enhanced response to Ca(2+)-mediated stimuli, as measured by increased sensitivity to C2-ceramide-induced apoptosis and by cAMP-responsive element-binding protein (CREB) phosphorylation in response to histamine. p13(II)-expressing Jurkat T cells also exhibited reduced proliferation, suggesting that the protein might exert similar effects in T cells, the primary target of HTLV-1 infection. These findings provide clues into the function of p13(II) as a negative regulator of cell growth and underscore a link between mitochondria, Ca(2+) signaling, and tumorigenicity.
A fully integrated 75–83 GHz FMCW synthesizer for automotive radar applications with −97 dBc/Hz phase noise at 1 MHz offset and 100 GHz/mSec maximal chirp rate (2017)

We present a SiGe BiCMOS fully integrated 75-83 GHz FMCW synthesizer for automotive radar applications. Performance enhancements were achieved by utilizing the bulk-drain parasitic variable capacitance of P-channel transistors, embedded in a gm-boosted Colpitts VCO, for frequency control. This mechanism was incorporated in a dual path PLL, providing low loop bandwidth variation over the whole output frequency range, -97 dBc/Hz phase noise at 1 MHz offset and maximum chirp rate of 100 GHz/mSec.
A Fuzzy Inverse Model Construction Method for a General MISO System with a Monotonic Input-output Relationship (2007)

This paper presents a novel method of systematically constructing the fuzzy inverse model for a general multi-input single-output (MISO) system represented with triangular input membership functions, singleton output membership function and fuzzy-mean defuzzification. The fuzzy inverse model construction method has the ability of uniquely determining the inverse relationship for each input-output pair. It is derived in a straightforward way and the required input variables can be simultaneously obtained by the fuzzy inferencing calculation to realize the desired output value. Simulation examples are provided to demonstrate the effectiveness of the proposed method to find the inverse kinematics solutions for complex industrial robot manipulators.
KCNJ5 mutations in the National Institutes of Health cohort of patients with primary hyperaldosteronism: an infrequent genetic cause of Conn's syndrome (2012)

KCNJ5 mutations were recently described in primary hyperaldosteronism (PH or Conn's syndrome). The frequency of these mutations in PH and the way KCNJ5 defects cause disease remain unknown. A total of 53 patients with PH have been seen at the National Institutes of Health over the last 12 years. Their peripheral and tumor DNAs (the latter from 16 that were operated) were screened for KCNJ5 mutations; functional studies on the identified defects were performed after transient transfection. Only two mutations were identified, and both in the tumor DNA only. There were no germline sequencing defects in any of the patients except for known synonymous variants of the KCNJ5 gene. One mutation was the previously described c.G451C alteration; the other was a novel one in the same codon: c.G451A; both lead to the same amino acid substitution (G151R) in the KCNJ5 protein. Functional studies confirmed previous findings that both mutations caused loss of channel selectivity and a positive shift in the reversal potential. In conclusion, the KCNJ5 protein was strongly expressed in the zona glomerulosa of normal adrenal glands but showed variable expression in the aldosterone-producing adenomas with and without mutation. The rate of KCNJ5 mutations among patients with PH and/or their tumors is substantially lower than what was previously reported. The G151R amino acid substitution appears to be the most frequent one so far detected in PH, despite additional nucleotide changes. The mutation causes loss of this potassium channel's selectivity and may assist in the design of new therapies for PH.
Supplemental table S1 from Dose Escalation of Tamoxifen in Patients with Low Endoxifen Level: Evidence for Therapeutic Drug Monitoring—The TADE Study (2023)

&lt;p&gt;CYP2D6 genotype and phenotype for each subject&lt;/p&gt;
Combining chromosomal arm status and significantly aberrant genomic locations reveals new cancer subtypes (2008)

Many types of tumors exhibit chromosomal losses or gains, as well as local amplifications and deletions. Within any given tumor type, sample specific amplifications and deletionsare also observed. Typically, a region that is aberrant in more tumors,or whose copy number change is stronger, would be considered as a more promising candidate to be biologically relevant to cancer. We sought for an intuitive method to define such aberrations and prioritize them. We define V, the volume associated with an aberration, as the product of three factors: a. fraction of patients with the aberration, b. the aberrations length and c. its amplitude. Our algorithm compares the values of V derived from real data to a null distribution obtained by permutations, and yields the statistical significance, p value, of the measured value of V. We detected genetic locations that were significantly aberrant and combined them with chromosomal arm status to create a succint fingerprint of the tumor genome. This genomic fingerprint is used to visualize the tumors, highlighting events that are co ocurring or mutually exclusive. We allpy the method on three different public array CGH datasets of Medulloblastoma and Neuroblastoma, and demonstrate its ability to detect chromosomal regions that were known to be altered in the tested cancer types, as well as to suggest new genomic locations to be tested. We identified a potential new subtype of Medulloblastoma, which is analogous to Neuroblastoma type 1.
Mechanisms of acquired thymic tolerance in experimental autoimmune encephalomyelitis: thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo. (1995)

Experimental autoimmune encephalomyelitis (EAE), an experimental model for the study of multiple sclerosis, is an autoimmune disease of the central nervous system that can be induced in a number of species by immunization with myelin basic protein (MBP). MBP-reactive CD4+ T cells, predominantly expressing the V beta 8.2 T cell receptor (TCR), migrate from the peripheral lymphoid organs and initiate the inflammatory response in the brain. We have previously shown that a single intrathymic injection of MBP or its major encephalitogenic peptide (p71-90), but not a nonencephalitogenic peptide (p21-40), induces antigen-specific systemic tolerance and inhibits the induction of EAE in Lewis rats. In this study, we investigated the mechanisms of induction and maintenance of acquired thymic tolerance in this model. First, we investigated which thymic cell is responsible for "induction" of systemic tolerance. Thymic dendritic-enriched cells, isolated by plastic adherence, when incubated in vitro with p71-90 and injected intravenously into Lewis rats, were capable of preventing the development of EAE, but his protection was lost in thymectomized recipients. In addition, intravenous injection of thymic dendritic cells isolated from animals that had been previously injected intrathymically with p71-90 but not p21-40 also prevented the development of EAE. Second, to determine the "effector" mechanisms involved in acquired thymic tolerance, we compared TCR expression in the brains of animals with actively induced EAE with TCR expression in animals that received intrathymic injection of p71-90 or p21-40. Using a semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) technique, we found increased expression of CD4 and V beta 8.2 message in brains of immunized animals compared with those of naive animals. In animals intrathymically injected with p71-90 but not p21-40, CD4 and V beta 8.2 transcript levels were significantly reduced compared with immunized controls. Immunohistologic studies of brain tissue and spleens with specific V beta 8.2 and control V beta 10 monoclonal antibodies confirmed these observations in vivo. These findings, taken together with recent data demonstrating that activated T cells circulate through the thymus, suggest that interaction of thymic dendritic cells with specific TCR of activated peripheral T cells can lead to inactivation of these antigen-specific cells and confirm the role of V beta 8.2-expressing T cells in EAE.
The Carnegie Mellon Laptop Orchestra (2018)

The Carnegie Mellon Laptop Orchestra (CMLO) is a collection of computers that communicate through a wireless network and collaborate to generate music. The CMLO is the culmination of a course on Computer Music Systems and Information Processing, where students learn and apply techniques for audio and MIDI programming, real-time synchronization and scheduling, music representation, and music information retrieval.
Identification of filamin C as a new physiological substrate of PKBα using KESTREL (2004)

We detected a protein in rabbit skeletal muscle extracts that was phosphorylated rapidly by PKBa (protein kinase Ba), but not by SGK1 (serum- and glucocorticoid-induced kinase 1), and identified it as the cytoskeletal protein FLNc (filamin C). PKBa phosphorylated FLNc at Ser2213 in vitro, which lies in an insert not present in the FLNa and FLNb isoforms. Ser2213 became phosphorylated when C2C12 myoblasts were stimulated with insulin or epidermal growth factor, and phosphorylation was prevented by low concentrations of wortmannin, at which it is a relatively specific inhibitor of phosphoinositide 3-kinase. PD 184352 [an inhibitor of the classical MAPK (mitogen-activated protein kinase) cascade] and/or rapamycin [an inhibitor of mTOR (mammalian target of rapamycin)] had no effect. Insulin also induced the phosphorylation of FLNc at Ser2213 in cardiac muscle in vivo, but not in cardiac muscle that does not express PDK1 (3-phosphoinositide-dependent kinase 1), the upstream activator of PKB. These results identify the muscle-specific isoform FLNc as a new physiological substrate for PKB.
Analysis of a diffusion‐limited hollow fiber reactor for the measurement of effective substrate diffusivities (1985)

Mathematical analyses of a diffusion-limited hollow fiber reactor for the measurement of effective substrate diffusivities are presented. An analytical solution to the mathematical model with a first order substrate consumption rate is used to show that the procedure of Webster and Shuler(1) is incorrect. A rigorous analysis that requires numerical solution is also outlined for any form of the substrate consumption rate. These analyses allow for more accurate estimations of effective substrate diffusivities since they should be used in conjunction with integral reactor behavior.