gebhart/patrepeval huggingface dataset:
Design of an Acoustic Transmitter for Temperature-Pressure Dual Sensing in Injection Molding (2006)

This paper presents a new sensing method for the simultaneous measurement of temperature and pressure within an injection mold cavity for molding process monitoring. A temperature-dependent oscillator (TSO) was designed to convert changes in the polymer melt temperature into carrier frequency shifts of the TSO by means of a temperature-sensitive capacitor. The frequency shifts are then utilized to modulate ultrasonic pulses generated by an ultrasonic transmitter. The ultrasonic transmitter is powered by energy extracted from the melt pressure by means of a piezoceramic stack. The transmitter and the TSO were represented by an equivalent circuit, and its Mason's model was analyzed to assist in the parametric design and function simulation of the transmitter. Results of simulation were experimentally verified and a good agreement was found.
Single-mode air-guiding photonic bandgap fiber with improved broadband transmission characteristics: The benefits of an anti-resonant core design (2007)

The condition for single-mode operation in photonic band-gap fibers (PBGFs) is investigated. If the silica-ring satisfies an anti-resonant condition, the PBGF with a realistic core exhibits a single-mode operation over a wide wavelength range.
A Phase 1/2 Study of a Respiratory Syncytial Virus Prefusion F Vaccine With and Without Adjuvant in Healthy Older Adults (2022)

RSVpreF formulations were well tolerated and elicited robust neutralizing responses in older adults; however, CpG/Al(OH)3 did not further enhance responses. Clinical Trials Registration. NCT03572062.
FUNDAMENTALS OF TRAFFIC ENGINEERING. 12TH EDITION. REPRINT (1989)

This publication contains information (referred to as course notes) designed mainly for one-week short courses on the fundamentals of traffic engineering, with a California audience in mind. The 12th edition includes new and updated material that may also be useful to the practicing traffic engineer. In particular, it reflects the publication of new editions of the Highway Capacity Manual and the Policy on the Geometric Design on Highways and Streets, both of which occurred since the 11th Edition of these notes went to press. Several other chapters have been greatly revised. A new appendix, summarizing statistical methods commonly used in traffic engineering work, has been added. The appendix which translated certain data in past editions from British to metric units has been reduced to a single table of equivalents in view of the lack of progress in the United States in converting to the SI system of units. This reprint of the 12th Edition is identical to the original printing (January 1988) except for: correction of typographical and production errors; revision of Table 8-3; and correction through updating of obsolete information in the legal reference footnote on page 14-8, and in the last paragraph under D.3.b. of Chapter 22 (page 22-4).
Theory and application of differential OTF (dOTF) wavefront sensing (2012)

A new image-based technique for measuring the complex field in the pupil of a telescope is presented. The simplest form of the method uses two point source images, one with a small modification introduced in the pupil. The processing of the images is very simple and non-iterative. The method is based on a specially-defined complex functional derivative of the OTF. This derivative is approximated empirically by the difference between the Fourier transforms of the two PSFs: the differential OTF or "dOTF." Due to the complex conjugate in the OTF, the dOTF includes two complex images of the complex pupil field overlapping at the point of pupil modification. By placing the modification near the edge of the pupil, the overlap region can be minimized. The overlap region is typically small, but can be eliminated altogether by using a second modification and a third image. The technique can use broadband light, but the result incurs a radial blurring proportional to the fractional bandwidth. This is also easily dealt with using another modification and image. Although the dOTF a poor match for high frame rate astronomical AO applications, it has many potential uses. Optical shop testing, non-common-path wavefront error estimation, alignment and vignetting, telescope segment phasing, general imaging system diagnostics and testing applications are considered. More advanced applications are possible with extensions to the theory, such as extended incoherence background scenes as sources instead of stars, and 3-D tomographic aberration and transmission mapping open up many new applications.
Hormonal Regulation of 3′,5′-Adenosine Monophosphate Phosphodiesterases in Cultured Rat Granulosa Cells* (1984)

The effect of gonadotropins on phosphodiesterase activity of rat granulosa cells was studied in an in vitro model. Granulosa cells were prepared from hypophysectomized or intact, estrogen-primed immature female rats and treated with FSH, hCG, or (Bu)2cAMP in vitro. Phosphodiesterase activity was determined in cell homogenates. FSH treatment for 2 days produced a marked increase in phosphodiesterase activity, while hCG was ineffective. FSH stimulation was potentiated by the addition of 1-methyl-3-isobutylxanthine, while treatment with the cAMP analog, (Bu)2cAMP by itself also markedly stimulated enzyme activity. FSH stimulated cAMP, but not cGMP, hydrolysis, suggesting that a phosphodiesterase specific for cAMP was stimulated by the gonadotropin. Time-course studies showed that an increase in phosphodiesterase activity was apparent after 1 h of incubation and was maximal at 48 h. FSH stimulation of phosphodiesterase was dose-dependent, with an ED50 of 30 ng/ml FSH and a maximal increase at 100-300 ng/ml. Treatment with cycloheximide (1 or 10 micrograms/ml) completely blocked the gonadotropin stimulation, suggesting that on-going protein synthesis is required for the FSH action. DEAE-cellulose chromatography of soluble extracts of control and FSH-treated cells indicated that two forms of phosphodiesterase were present in unstimulated granulosa cells. The first form, eluting at 0.17 M Na-acetate, hydrolyzed both cAMP and cGMP and was stimulated by Ca++ and calmodulin; the second form, eluting at 0.48 M Na-acetate, was insensitive to Ca++ or calmodulin and hydrolyzed mainly cAMP. FSH treatment markedly stimulated cAMP hydrolysis by the calmodulin-dependent first form as well as that by the second form. Double reciprocal analysis indicated that the FSH-stimulated enzymes are of high affinity for cAMP. In agreement with the data on total homogenate, the cGMP hydrolysis was not affected by the hormone treatment. These data demonstrate that FSH stimulates cAMP, but not cGMP, phosphodiesterase activity in rat granulosa cells in vitro. This stimulation might represent a mechanism for termination of the FSH primary stimulus and regulation of granulosa cell responsiveness to the gonadotropin.
Signal Processing Algorithms in 100Gb/s Optical Coherent and Non-coherent Receivers with PSK Modulation (2010)

This paper addresses multi-level PSK modulation formats with coherent and non-coherent detection and reviews signal processing algorithms like mitigation of phase noise, the clock and carrier recovery algorithms as well as the equalizer structures and their performance.
Surface Chemical Functionalization to Achieve Extreme Levels of Molecular Confinement in Hybrid Nanocomposites (2019)

Abstract Polymer confinement is realized in hybrid nanocomposites where individual polymer molecules are confined by a nanoporous matrix to dimensions less than the molecular size of the polymer. Here it is shown that by functionalizing the interior pore surfaces of a nanoporous organosilicate matrix, the pores can be filled with polystyrene molecules to achieve extreme levels of molecular confinement not previously possible. This provides opportunities for unique thermal and mechanical properties. It is shown that pore surface functionalization markedly impacts the polymer mobility during polymer infiltration by affecting the polymer–pore surface interaction, addressing the challenge of filling high‐molecular‐weight polymer molecules into nanoscale‐confined spaces. This allows for achieving extreme levels of molecular confinement with the loss of interchain entanglement and extensive polymer elongation along the pore axis. The glass transition temperature of the polymer is suppressed compared to bulk polymer melt, and is significantly affected by the polymer–surface interaction, which changes the polymer segmental mobility. The polymer–surface interaction also affects the interfacial polymer–pore sliding shear stress during polymer pullout from the nanopores, markedly affecting the fracture resistance of the nanocomposite.
Platelet receptor recognition domain on the .gamma. chain of human fibrinogen and its synthetic peptide analogs [Erratum to document cited in CA110(17):151810E] (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPlatelet receptor recognition domain on the .gamma. chain of human fibrinogen and its synthetic peptide analogs [Erratum to document cited in CA110(17):151810E]Marek Kloczewiak, Sheila Timmons, Maria A. Bednarek, Masato Sakon, and Jacek HawigerCite this: Biochemistry 1989, 28, 19, 7974Publication Date (Print):September 19, 1989Publication History Published online1 May 2002Published inissue 19 September 1989https://pubs.acs.org/doi/10.1021/bi00445a065https://doi.org/10.1021/bi00445a065research-articleACS PublicationsRequest reuse permissionsArticle Views15Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supramolecular dimerization of a hexameric hemoprotein via multiple pyrene-pyrene interactions (2019)

Protein assemblies are being investigated as a new-class of biomaterials. A supramolecular assembly of a mutant hexameric tyrosine coordinated hemoprotein (HTHP) modified with a pyrene derivative is described. Cysteine was first introduced as a site-specific reaction point at position V44 which is located at the bottom surface of the cylindrical structure of HTHP. [Formula: see text]-(1-pyrenyl)maleimide was then reacted with the mutant. The modification was confirmed by MALDI-TOF mass spectrometry and UV-vis absorption spectroscopy, indicating that approximately 90% cysteine residues are attached via the pyrene derivative. Size exclusion chromatography (SEC) measurements for pyrene-attached HTHP include a single peak which elutes earlier than the unmodified HTHP. Further investigation by SEC and dynamic light scattering (DLS) measurements indicate the desired size corresponding to the dimer of the hemoprotein hexamers. The multivalent effect of pyrene–pyrene interactions including hydrophobic and [Formula: see text]–[Formula: see text] stacking interactions appears to be responsible for including formation of the stable dimer of the hexamers. Interestingly, the assembly dissociates to the hexamer by removal of heme. In the case of the apo-form of pyrene-attached HTHP, the pyrene moiety appears to be incorporated into the heme pocket because the modification point is located at the adjacent residue of the Tyr45 coordinating to heme in the holo-form of HTHP. Subsequent addition of heme into the apo-form of pyrene-attached HTHP regenerates the dimer of the hexamers. The present study demonstrates a unique heme-dependent system in which HTHP is assembled to form a dimer of hexamers in the presence of heme and disassembled by removal of heme.
Crystal Engineering of Dibenzothiophenothieno[3,2-b]thiophene (DBTTT) Isomers for Organic Field-Effect Transistors (2018)

Three thiophene ring-terminated benzothieno[3,2-b]benzothiophene (BTBT) derivatives, C-C6-DBTTT, C-C12-DBTTT, and L-C12-DBTTT, were designed and synthesized, differing in the isomerization of alkyl chain position as well as aromatic core construction. A study of crystal structure and electronic properties combined with a theoretical investigation was performed to understand the structure–property relationships for the application of these molecules in organic field-effect transistors (OFETs). Different crystal packing structures were observed for these three isomers by single-crystal X-ray diffraction as a result of a crystal engineering molecular design approach. The highest charge-carrier mobility was observed for the isomer with a collinear core, L-C12-DBTTT. Preliminary results demonstrated a promising hole mobility of 2.44 cm2 V–1 s–1, despite the polymorphism observed in ambient conditions.
Impact of precursor concentration on the properties of perovskite solar cells obtained from the dehydrated lead acetate precursors (2021)

In this research, we examined the impact of solution concentration on the photovoltaic and the material properties of perovskite solar cells (PSCs) obtained from dehydrated Pb-acetate precursors. The perovskite solution was deposited by a one-step spin-coating technique followed by 5 min of thermal annealing on a hotplate at the temperature of 90 °C to form the perovskite active layer. The PSC device structure adopted was the inverted planar architecture. The precursor solution concentrations were varied from 0.7 to 1.1M, with the optimal solution concentration found to be 1.0M. This concentration results in a power conversion efficiency of 12.2%, an open circuit voltage (Voc) of 0.94 V, a short circuit photocurrent density (Jsc) of 20.71 mA/cm2, and a fill factor of 62.69%. Our investigations revealed that the precursor solution concentration had a huge effect on the quality of the perovskite film and the photovoltaic properties of the PSCs.
Localization and Interpretation of Bubble Activity during HIFU Exposure (2009)

Bubble activity has been found to play a key role in many HIFU applications, ranging from thermal ablation to histotripsy. A combined active‐passive cavitation detection system is presented, which enables localization of bubble activity with respect to the HIFU focus during HIFU exposure. The system consists of a high‐frequency detector positioned coaxially with the therapy transducer, either driven in pulse‐echo mode or used passively. Spectral analysis of the received signal makes it possible to distinguish between inertial cavitation and thermally induced bubble activity, and to track the evolution of either bubble population during HIFU exposure. Inertial cavitation is found to play a key role in the early stages of HIFU exposure, beyond which it gradually shuts down under the effect of heating. Thermal bubbles appear in the later stages of HIFU exposure, are most readily tracked by the active detection scheme, and gradually migrate towards the pre‐focal region. This dual active‐passive cavitation system could provide an invaluable tool for ensuring both treatment safety and efficacy during clinical HIFU application.
Safety and Risk of Major Complications With Diagnostic Cardiac Catheterization (2019)

The overall rates of major complications related to diagnostic cardiac catheterization procedures are extremely rare. The majority of the deaths occurring post-diagnostic LHC procedures were secondary to acute illness rather than directly related to diagnostic procedure.
ChemInform Abstract: Catalytic Enantioselective 1,3‐Dipolar Cycloaddition Reactions of Cyclic Nitrones: A Simple Approach for the Formation of Optically Active Isoquinoline Derivatives. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Introduction of an N-Glycosylation Site Increases Secretion of Heterologous Proteins in Yeasts (2000)

Saccharomyces cerevisiae is often used to produce heterologous proteins that are preferentially secreted to increase economic feasibility. We used N-glycosylation as a tool to enhance protein secretion. Secretion of cutinase, a lipase, and llama V(HH) antibody fragments by S. cerevisiae or Pichia pastoris improved following the introduction of an N-glycosylation site. When we introduced an N-glycosylation consensus sequence in the N-terminal region of a hydrophobic cutinase, secretion increased fivefold. If an N-glycosylation site was introduced in the C-terminal region, however, secretion increased only 1.8-fold. These results indicate that the use of N glycosylation can significantly enhance heterologous protein secretion.
Potentialities of the Poly(Aminoethyl Methacrylate) p(AMA) as Gelatin-Like Polymer in Complex Coacervation (2016)

In order to overcome all encapsulation variations during a complex coacervation process, the replacement of gelatin cationic polymer has been performed using p(AMA). The synthesis of p(AMA) was realized through a random radical methodology. Under these conditions a polymer with 18,600 g/mol was found appropriate for optimal capsule yield and physico-chemical properties. Turbidity measurements performed during the coacervation reactions with different ratios of both CMC and p(AMA) allowed optimizing coacervation conditions. Coacervates characterizations particularly demonstrate the stability of the capsules exhibiting a break strength over 3 N/m 2 .
Topology optimised photonic crystal waveguide intersections with high-transmittance and low crosstalk (2006)

Numerical and experimental studies on the photonic crystal waveguide intersection based on the topology optimisation design method are reported and the effectiveness of this technique is shown by achieving high transmittance spectra with low crosstalk for the straightforward beam-propagation line in the intersection.
Modeling crosshatch surface morphology in growing mismatched layers. Part II: Periodic boundary conditions and dislocation groups (2004)

We present further developments and understanding of the commonly observed crosshatch surface morphology in strain-relaxed heteroepitaxial films. We have previously proposed that the crosshatch morphology is directly related with strain relaxation via threading dislocation glide which results in both surface step and misfit dislocation (MD) formation [see Andrews et al., J. Appl. Phys. 91, 1933 (2002)—now referred to as Part I]. In this article, we have used solutions for the stress fields and displacement fields for periodic MD arrays which include the effects of the free surface. These solutions avoid truncation errors associated with finite dislocation arrays that were used in Part I. We have calculated the surface height profile for relaxed films where the misfit dislocations were introduced randomly or the misfit dislocations were placed in groups with alternating sign of the normal component of their Burgers vector. We have calculated the surface height profiles where the slip step remains at the surface [“slip step only” (SSO)] and where the slip step is eliminated [“slip step eliminated” (SSE)] due to annihilation of opposite sense steps, such as could happen during growth or lateral mass transport. For relaxed films, we find that the surface height undulations, characteristic of crosshatch, increase with increasing film thickness for the SSO case, whereas the surface becomes flatter for the SSE case. Experiments on relaxed In0.25Ga0.75As films on (001) GaAs show that the surface height undulations in the [110] direction increase with increasing film thickness. Thus, we conclude that with increasing film thickness the crosshatch in the slow diffusion [110] direction is best described by the SSO case.
Decatransin, a novel natural product inhibiting protein translocation at the Sec61/SecY translocon (2015)

A new cyclic decadepsipeptide was isolated from Chaetosphaeria tulasneorum with potent bioactivity on mammalian and yeast cells. Chemogenomic profiling in S. cerevisiae indicated that the Sec61 translocon complex, the machinery for protein translocation and membrane insertion at the endoplasmic reticulum, is the target. The profiles were similar to those of cyclic heptadepsipeptides of a distinct chemotype (including HUN-7293 and cotransin) that had previously been shown to inhibit cotranslational translocation at the mammalian Sec61 translocon. Unbiased, genome-wide mutagenesis followed by full-genome sequencing in both fungal and mammalian cells identified dominant mutations in Sec61p (yeast) or Sec61α1 (mammals) that conferred resistance. Most, but not all, of these mutations affected inhibition by both chemotypes, despite an absence of structural similarity. Biochemical analysis confirmed inhibition of protein translocation into the endoplasmic reticulum of both co- and post-translationally translocated substrates by both chemotypes, demonstrating a mechanism independent of a translating ribosome. Most interestingly, both chemotypes were found to also inhibit SecYEG, the bacterial Sec61 translocon homolog. We suggest 'decatransin' as the name for this new decadepsipeptide translocation inhibitor.
Short Article Sho1 and Pbs2 Act as Coscaffolds Linking Components in the Yeast High Osmolarity MAP Kinase Pathway (2004)

Summary (Elion, 2001). Because the scaffold organizes these pro- teins into a distinct complex, Ste11 molecules activated Scaffoldproteinsmediateefficientandspecificsignal- by the pheromone input are specifically directed to acti-ing in several mitogen-activated protein (MAP) kinase vate the downstream mating kinases Ste7 and Fus3 cascades. In the yeast high osmolarity response path- (Harris et al., 2001).way,theMAPkinasekinasePbs2isthoughttofunction Similarly, in one branch of the high osmolarity re- as a scaffold, since it binds the osmosensor Sho1, the sponse pathway, the MAPKK Pbs2 acts as a scaffoldupstream MAP kinase kinase kinase Ste11, and the as well as a kinase (Figure 1A) (Posas and Saito, 1997). downstreamMAPkinaseHog1.Nonetheless,previous Itinteracts withtheosmosensorSho1 throughaproline-work has shown that Ste11 can be activated even rich peptide in Pbs2 that is recognized by a Src homol- whenPbs2isdeleted,resultingininappropriatecross- ogy 3 (SH3) domain in Sho1. In addition, Pbs2 interactstalk to the mating pathway. We have found a region
Study of a topology optimization tool associating a hybrid algorithm with a Vorono&#x00EF;-based formalism for the design of electromagnetic devices (2010)

This paper presents and compares three topology optimization tools differing from the optimization algorithms they implement. The first two are respectively based on a local optimization algorithm, i.e. a Nelder-Mead method, and a global one, i.e. a genetic algorithm. The third uses a hybrid algorithm associating the local and the global algorithms used in the first two. Each of them implements the same material distribution formalism, i.e. a dynamic formalism based on Voronoi cells. The results obtained on a practical study case, the design of an electromagnet, show the better performance of the hybrid algorithm as well in terms of speed of the convergence as in terms of quality of the final solution and therefore the interest of coupling the exploration ability of the global search with the intensification ability of the local search.