gebhart/patrepeval huggingface dataset:
Gate Oxide Reliability of SiC MOSFETs and Capacitors Fabricated on 150mm Wafers (2019)

Gate oxide reliability on silicon carbide MOSFETs and large-area SiC N-type capacitors was studied for devices fabricated on 150mm SiC substrates. Oxide lifetime was measured under accelerated stress conditions using constant-voltage time-dependent dielectric breakdown (TDDB) testing, or ramped-voltage breakdown (RBD) testing. TDDB results from 1200V Gen3 MOSFETs reveal a field acceleration parameter of about 35 nm/V, similar to values reported for SiO 2 on silicon. Temperature-dependent RBD tests of large capacitors from 25°C to 200°C reveal an apparent activation energy of 0.24eV, indicating that oxide lifetime increases as the temperature is decreased, as expected. Using this acceleration parameter and activation energy in the linear field model, the gate oxide lifetime from MOSFET TDDB testing extrapolates to greater than 10 8 hours at a gate voltage of 15 V GS at 175°C.
Investigation of Bradykinin metabolism in human and rat plasma in the presence of the dual ace/NEP inhibitors GW660511X and omapatrilat (2002)

Several studies have suggested that the accumulation of bradykinin, or that of one its metabolites BK1-8, is involved in the occurrence of side effects such as AE associated with the use of various ACEi. In this work a novel approach combining HPLC-UV on-line with oaTOF-MS and ICPMS was applied to investigate in human and rat plasma the metabolism of labelled BK (79/81 Br-Phe5) BrBK in the presence of two new dual ACE/NEP inhibitors (GW660511X and omapatrilat) currently under clinical trial. In human plasma the BrBK half-life values in the absence or in the presence of GW660511X (3.8 microM) or omapatrilat (32 nM) were 38.7 +/- 2.4, 51.2 +/- 4.7 and 114.7 +/- 9.3 min, respectively and BrBK was degraded into BrBK1-8, BrBK1-7, BrBK1-5 and Br-Phe. In the presence of inhibitors, however, the levels of these resultant metabolites were different. Unlike GW660511X, omapatrilat abolished the production of BrBK1-5 and BrBK1-7, suggesting a better ACE inhibition effect over GW660511X as no NEP activity was found. In addition the production of BrBK1-8 was enhanced in the presence of these inhibitors with a greater accumulation being observed with omapatrilat. The production of Br-Phe5 was reduced with GW660511X while no significant change was observed with omapatrilat after 4 h of incubation. In rat plasma the BrBK half-life values in the absence or in the presence of GW660511X (530 nM) or omapatrilat (50 nM) were 9.31 +/- 1.7, 22.06 +/- 3.1 and 25.3 +/- 1.7 min, respectively and BrBK was degraded into BrBK1-8, BrBK1-7, BrBK1-5 and Br-Phe5 plus BrBK2-9, BrBK4-8 and BrBK2-8 metabolites not found in human plasma. GW660511X and omapatrilat reduced the production of BrBK1-5 and BrBK1-7 with more effect being observed with omapatrilat. GW660511X and omapatrilat increased the production of both BrBK1-8 and Br-Phe5 but not that of BrBK4-8 and BrBK2-8. This study shows that the potency of GW660511X in comparison with omapatrilat is more than 100-fold lower in human, but less than 10-fold lower in rat plasma, suggesting that rat may not be a suitable in vivo model for the evaluation of ACE/NEP inhibition in relation to effects in humans.
AVATecH â€• automated annotation through audio and video analysis (2012)

In different fields of the humanities annotations of multimodal resources are a necessary component of the research workflow. Examples include linguistics, psychology, anthropology, etc. However, creation of those annotations is a very laborious task, which can take 50 to 100 times the length of the annotated media, or more. This can be significantly improved by applying innovative audio and video processing algorithms, which analyze the recordings and provide automated annotations. This is the aim of the AVATecH project, which is a collaboration of the Max Planck Institute for Psycholinguistics (MPI) and the Fraunhofer institutes HHI and IAIS. In this paper we present a set of results of automated annotation together with an evaluation of their quality.
MediaBench: a tool for evaluating and synthesizing multimedia and communications systems (2002)

Significant advances have been made in compilation technology for capitalizing on instruction-level parallelism (ILP). The vast majority of ILP compilation research has been conducted in the context of general-purpose computing, and more specifically the SPEC benchmark suite. At the same time, a number of microprocessor architectures have emerged which have VLIW and SIMD structures that are well matched to the needs of the ILP compilers. Most of these processors are targeted at embedded applications such as multimedia and communications, rather than general-purpose systems. Conventional wisdom, and a history of hand optimization of inner-loops, suggests that ILP compilation techniques are well suited to these applications. Unfortunately, there currently exists a gap between the compiler community and embedded applications developers. This paper presents MediaBench, a benchmark suite that has been designed to fill this gap. This suite has been constructed through a three-step process: intuition and market driven initial selection, experimental measurement to establish uniqueness, and integration with system synthesis algorithms to establish usefulness.
Multicationic Sr4Mn3O10 mesostructures: molten salt synthesis, analytical electron microscopy study and reactivity (2018)

Molten salt synthesis of anisotropic Sr<sub>4</sub>Mn<sub>3</sub>O<sub>10</sub> particles.
Diagnosis of iron deficiency anemia using density-based fractionation of red blood cells (2016)

Iron deficiency anemia (IDA) is a nutritional disorder that impacts over one billion people worldwide; it may cause permanent cognitive impairment in children, fatigue in adults, and suboptimal outcomes in pregnancy. IDA can be diagnosed by detection of red blood cells (RBCs) that are characteristically small (microcytic) and deficient in hemoglobin (hypochromic), typically by examining the results of a complete blood count performed by a hematology analyzer. These instruments are expensive, not portable, and require trained personnel; they are, therefore, unavailable in many low-resource settings. This paper describes a low-cost and rapid method to diagnose IDA using aqueous multiphase systems (AMPS)-thermodynamically stable mixtures of biocompatible polymers and salt that spontaneously form discrete layers having sharp steps in density. AMPS are preloaded into a microhematocrit tube and used with a drop of blood from a fingerstick. After only two minutes in a low-cost centrifuge, the tests (n = 152) were read by eye with a sensitivity of 84% (72-93%) and a specificity of 78% (68-86%), corresponding to an area under the curve (AUC) of 0.89. The AMPS test outperforms diagnosis by hemoglobin alone (AUC = 0.73) and is comparable to methods used in clinics like reticulocyte hemoglobin concentration (AUC = 0.91). Standard machine learning tools were used to analyze images of the resulting tests captured by a standard desktop scanner to 1) slightly improve diagnosis of IDA-sensitivity of 90% (83-96%) and a specificity of 77% (64-87%), and 2) predict several important red blood cell parameters, such as mean corpuscular hemoglobin concentration. These results suggest that the use of AMPS combined with machine learning provides an approach to developing point-of-care hematology.
Innentitelbild: Amplified Chiral Transformation through Helical Assembly (Angew. Chem. 34/2007) (2007)

„Chiralitätsverstärkung“ durch Umwandlung eines Substrats in eine helicale polymere Vorstufe, in der die Händigkeit durch das “Mehrheitsprinzip” bestimmt wird, schildern T. Aida et al. in der Zuschrift auf S. 6596 ff. Die grundlegende Strategie, die durch die asymmetrische Umwandlung eines D2-symmetrischen sattelförmigen Porphyrins mit Chiralitätsgedächtnis demonstriert wird, könnte ein neues Grundprinzip für die allgemeine asymmetrische Synthese bilden.
Distinguishing different stages of mouse pregnancy using Second Harmonic Generation images (2010)

This paper presents an image processing approach for distinguishing three pregnancy stages of mice using Second Harmonic Generation (SHG) microscopy images. Three classes of SHG images for day 6, day 12 and day 18 of the 19-day mouse gestation period are considered. A classification is performed based on morphological features previously used for such SHG images, wavelet-based texture features, and a combination of morphological and wavelet-based texture features. It is shown that the combination of the features provide a more effective mechanism for distinguishing the three stages of mouse pregnancy as compared to each separate set of features.
A TEM Study of Creep Deformation Mechanisms in Allvac 718Plus (2010)

This chapter contains sections titled: Introduction Materials and Experimental Procedure Results and Discussion Conclusions Acknowledgements
Quality indicators of laryngeal cancer care in commercially insured patients (2017)

2c. Laryngoscope, 127:2805-2812, 2017.
Discotic Mesogen (2016)

In the past, aggregation and self-assembly have been associated principally with micellar and colloidal systems of molecules; however, with the advent of supramolecular chemistry, molecular self-assembly has been opened to a much wider understanding that has facilitated access to a variety of different shapes and sizes, along with the construction of new and fascinating molecular topologies. This document aims at defining more than 150 terms related to aggregation and self-assembly in the particular case of macromolecules. The list is restricted to the most commonly encountered terms.
Every Bit Counts: Second-Order Analysis of Cooperation in the Multiple-Access Channel (2021)

The work at hand presents a finite-blocklength analysis of the multiple access channel (MAC) sum-rate under the cooperation facilitator (CF) model. The CF model, in which independent encoders coordinate through an intermediary node, is known to show significant rate benefits, even when the rate of cooperation is limited. We continue this line of study for cooperation rates which are sub-linear in the blocklength n. Roughly speaking, our results show that if the facilitator transmits log <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$K$</tex> bits, then there is a sum-rate benefit of order √log K/n compared to the best-known achievable rate. This result extends across a wide range of K: even a single bit of cooperation is shown to provide a sum-rate benefit of order 1/√n.
Development of a Novel Small Molecule CRM-1 Inhibitor for Non Hodgkin's Lymphoma (2011)

Abstract Abstract 598 Recent evidence demonstrates that Non Hodgkin's Lymphoma (NHL) tumors have elevated expression of the XPO1 gene that codes for the nuclear exporter protein CRM-1 controlling the localization of critical tumor suppressors including p53 family members. For effective apoptosis and cell cycle regulation, p53/p73 nuclear localization and DNA binding are highly critical making CRM-1 an attractive therapeutic target for NHL that carries &gt;90% wild type/functional p53 and only rare mutations in p73. We have identified novel small molecule inhibitors of CRM-1 (KPTs) that bind irreversibly and lock target proteins (including p53 and p73) in the nucleus leading to apoptosis of tumor cells. We demonstrate for the first time that KPTs can induce apoptosis in resistant NHL cell lines and corresponding xenograft models. The most potent CRM-1 inhibitor (KPT-185) induced growth inhibition and apoptosis in a panel of NHL cell lines with a median IC50 ∼25 nM. Western blot and confocal microscopy analyses demonstrated that KPT-185 treatment resulted in nuclear localization of p53 in wt-p53 and p73 in mut-p53 cell lines. Additionally, we observed KPT-185 mediated activation of p21 and Bax, known downstream executioners of p53/p73 cell cycle control and apoptosis, respectively. Most significantly, siRNA knockdown of p53 in WSU-FSCCL and p73 in WSU-DLCL2 abrogated the apoptotic potential of KPT-185, confirming that these were indeed p53/p73 dependent apoptotic events. KPT-185 showed a substantial enhancement in apoptosis when combined with genotoxic p53/p73 re-activating regimen CHOP. The KPTs selectively kill cancer cells with minimal toxicity to normal tissues, and possess clinically acceptable pharmacokinetic parameters. Using WSU-DLCL2 SCID models, we further show that oral administration of related CRM-1 inhibitor KPT-276 (75 and 150 mg/Kg p.o) resulted in 65 and 70% tumor reduction, respectively and subcutaneous injections of KPT-251 (25 and 75 mg/Kg) resulted in 70 and 74% suppression of tumor growth with no observed toxicity to the host. Remnant tumor tissue analysis (histology and protein markers) fell in line with our in vitro results with clear activation of p73 pathway. Our study verifies CRM-1 as a potential therapeutic target in NHL irrespective of the functional status of p53. These results build a strong case for the clinical use of our novel CRM-1 inhibitors either as single agents or in combination with CHOP. Disclosures: Kauffman: Karyopharm: Equity Ownership. McCauley:Karyopharm: Employment. Shacham:Karyopharm: Equity Ownership.
Making Security Viral: Shifting Engineering Biology Culture and Publishing (2022)

The ability to construct, synthesize, and edit genes and genomes at scale and with speed enables, in synergy with other tools of engineering biology, breakthrough applications with far-reaching implications for society. As SARS-CoV-2 spread around the world in early spring of 2020, researchers rapidly mobilized, using these tools in the development of diagnostics, therapeutics, and vaccines for COVID-19. The sharing of knowledge was crucial to making rapid progress. Several publications described the use of reverse genetics for the <i>de novo</i> construction of SARS-CoV-2 in the laboratory, one in the form of a protocol. Given the demonstrable harm caused by the virus, the unequal distribution of mitigating vaccines and therapeutics, their unknown efficacy against variants, and the interest in this research by laboratories unaccustomed to working with highly transmissible pandemic pathogens, there are risks associated with such publications, particularly as protocols. We describe considerations and offer suggestions for enhancing security in the publication of synthetic biology research and techniques. We recommend: (1) that protocol manuscripts for the <i>de novo</i> synthesis of certain pathogenic viruses undergo a mandatory safety and security review; (2) that if published, such papers include descriptions of the discussions or review processes that occurred regarding security considerations in the main text; and (3) the development of a governance framework for the inclusion of basic security screening during the publication process of engineering biology/synthetic biology manuscripts to build and support a safe and secure research enterprise that is able to maximize its positive impacts and minimize any negative outcomes.
Amyloplast Sedimentation Dynamics in Maize Columella Cells Support a New Model for the Gravity-Sensing Apparatus of Roots (2001)

Quantitative analysis of statolith sedimentation behavior was accomplished using videomicroscopy of living columella cells of corn (Zea mays) roots, which displayed no systematic cytoplasmic streaming. Following 90 degrees rotation of the root, the statoliths moved downward along the distal wall and then spread out along the bottom with an average velocity of 1.7 microm min(-1). When statolith trajectories traversed the complete width or length of the cell, they initially moved horizontally toward channel-initiation sites and then moved vertically through the channels to the lower side of the reoriented cell where they again dispersed. These statoliths exhibited a significantly lower average velocity than those sedimenting on distal-to-side trajectories. In addition, although statoliths undergoing distal-to-side sedimentation began at their highest velocity and slowed monotonically as they approached the lower cell membrane, statoliths crossing the cell's central region remained slow initially and accelerated to maximum speed once they reached a channel. The statoliths accelerated sooner, and the channeling effect was less pronounced in roots treated with cytochalasin D. Parallel ultrastructural studies of high-pressure frozen-freeze-substituted columella cells suggest that the low-resistance statolith pathway in the cell periphery corresponds to the sharp interface between the endoplasmic reticulum (ER)-rich cortical and the ER-devoid central region of these cells. The central region is also shown to contain an actin-based cytoskeletal network in which the individual, straight, actin-like filaments are randomly distributed. To explain these findings as well as the results of physical simulation experiments, we have formulated a new, tensegrity-based model of gravity sensing in columella cells. This model envisages the cytoplasm as pervaded by an actin-based cytoskeletal network that is denser in the ER-devoid central region than in the ER-rich cell cortex and is linked to stretch receptors in the plasma membrane. Sedimenting statoliths are postulated to produce a directional signal by locally disrupting the network and thereby altering the balance of forces acting on the receptors in different plasma membrane regions.
Bioengineered Human Acellular Vessels for Dialysis Access: Completed Phase 2 Studies (2017)

Lawson, Jeffrey H. MD, FACS; Glickman, Marc H. MD, FACS; Jakimowicz, Tomasz MD, PhD; Peden, Eric K. MD, FACS; Szmidt, Jacek MD, PhD; Witkiewicz, Wojciech MD, PhD; Zubilewicz, Tomasz MD, PhD; Niklason, Laura E. MD, PhD Author Information
The effect of translational and rotational traction on lower extremity joint loading (2015)

Previous studies have linked footwear traction to lower extremity non-contact injury; however, these studies mainly focussed on rotational traction exclusively. While studies have shown that increases in traction lead to increases in joint loading, represented by joint moments, these studies failed to determine how the individual components of rotational and translational traction affect joint loading. Therefore, this study investigated how each component of traction independently affects lower extremity joint loading. Traction testing was performed using a robotic testing machine on three shoes that had independent alterations of translational and rotational traction. All testing was conducted on a sample piece of artificial turf. Kinematic and kinetic data were then collected on 10 athletes performing two cutting movements in each shoe condition. As rotational and translational traction were independently altered, decreased rotational traction led to significant decreases in transverse and frontal plane joint loading at the ankle and knee joints, while increases in translational traction led to increases in frontal plane joint loading at the ankle and knee joints. Increases in joint loading in the transverse and frontal planes are one of the possible mechanisms of lower extremity non-contact injury. Both translational and rotational traction can independently alter the joint loading.
Uptake, Intracellular Distribution, and Stability of Oligodeoxynucleotide Phosphorothioate by Schistosoma mansoni (1995)

The in vitro uptake, cellular distribution, efflux, stability, and toxicity levels of an oligodeoxynucleotide phosphorothioate (PS-oligonucleotide) have been studied in mature Schistosoma mansoni worms. The intracellular accumulation of 35S-labeled PS-oligonucleotide occurred roughly in proportion to the worm body mass over a wide concentration range, whether the worms were exposed singly or in mating pairs. Cellular uptake was dependent on the extracellular concentration. A minor fraction (13%) of the PS-oligonucleotide taken up by the worm accumulated in the surface tegumental coat. Most of the PS-oligonucleotide taken up localized in the cytosol (54%) and the nuclei-enriched (33%) fractions. In a time course study on adult worms in culture, oligonucleotide uptake was observed within the first 2 h and peaked at about 36 h. A decrease in the intracellular concentration of the PS-oligonucleotide was observed by 42 h. Analysis of the extracted oligonucleotides showed that PS-oligonucleotide was digested slowly. Efflux of the oligonucleotide was time and temperature dependent. Significant toxicity to the cultured worms did not occur until the PS-oligonucleotide concentration was over 8 mg/ml (1 mM).
Array transmitter/receiver controlled by a true time-delay fiber-optic beamformer (1995)

We demonstrate a phased-array antenna controlled by a fiber-optic beamformer in true time-delayed transmit mode and in phase-delayed receive mode. The wavelength-tunable optical carrier propagating in a high-dispersion fiber realizes a true time-delay, with the steering direction set by a single voltage controlling the wavelength. The linear antenna is a sparsely-populated array with eight broadband spiral elements. The transmitter operates in 2-18 GHz frequency range over /spl plusmn/50/spl deg/ azimuth steering, and the receiver operates in 6-16 GHz frequency range over /spl plusmn/35/spl deg/ azimuth steering.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The classical and mannose binding lectin complement pathways have a differential effect on permeability and histological injury following ischemia-reperfusion (2004)

Chan, Rodney K. MD; Ibrahim, Shahrul MBBCh; Takahashi, Kazue PhD; Ezekowitz, Alan MD; Moore, Francis D. Jr MD, FACS; Austen, William G. Jr MD Author Information
A Non-invasive Platform for Functional Characterization of Stem-Cell-Derived Cardiomyocytes with Applications in Cardiotoxicity Testing (2015)

We present a non-invasive method to characterize the function of pluripotent stem-cell-derived cardiomyocytes based on video microscopy and image analysis. The platform, called Pulse, generates automated measurements of beating frequency, beat duration, amplitude, and beat-to-beat variation based on motion analysis of phase-contrast images captured at a fast frame rate. Using Pulse, we demonstrate recapitulation of drug effects in stem-cell-derived cardiomyocytes without the use of exogenous labels and show that our platform can be used for high-throughput cardiotoxicity drug screening and studying physiologically relevant phenotypes.