gebhart/patrepeval huggingface dataset:
An Integrated Circuit for Decoupling and Tuning of Inverted-F Antennas in Cellular User Equipment (2021)

An integrated circuit (IC) for decoupling of multiple-input multiple-output (MIMO) antennas as well as for aperture and impedance tuning is demonstrated in this paper. The IC decouples the adjacent stripes of the inverted-F antenna (IFA) forming the two separate IFAs for MIMO operation in middle- and high-cellular frequency bands. For low-band operation the IC joins the stripes, forming a single IFA with double the physical length. The same IC is also used for impedance and aperture tuning of the antennas. The IC is designed and fabricated in dedicated 130 nm RF switch technology. The design and measurement results are presented in the paper.
Single-phase dielectrophoretic and electrorotation studies using three dimensional electrodes for cell characterization (2014)

A novel electrokinetic approach using single-phase electrorotation for the label-free manipulation and characterization of biological cells is presented. A single shell model was used to theoretically design and develop an experimental strategy for biological particle characterization. As a study model, electro-rotation of glutathione agarose (GA) beads was studied using three-dimensional spatially oriented micro-needle setup. Effect of electrical parameters (i) voltage: from 0-10 Vpp and (ii) frequency: 0-100 MHz was evaluated on a heterogeneous mixture of GA beads (35-150 microns). The relationship of the electrical parameters to rotational frequency of the beads was studied. This paper demonstrates a simple and easy to implement prototype for electrokinetic characterization of particles with translational potential for biological cells.
Vacuum ultraviolet radiation effects on two-dimensional MoS2 field-effect transistors (2017)

Atomically thin MoS2 has generated intense interest for emerging electronics applications. Its two-dimensional nature and potential for low-power electronics are particularly appealing for space-bound electronics, motivating the need for a fundamental understanding of MoS2 electronic device response to the space radiation environment. In this letter, we quantify the response of MoS2 field-effect transistors (FETs) to vacuum ultraviolet (VUV) total ionizing dose radiation. Single-layer (SL) and multilayer (ML) MoS2 FETs are compared to identify differences that arise from thickness and band structure variations. The measured evolution of the FET transport properties is leveraged to identify the nature of VUV-induced trapped charge, isolating the effects of the interface and bulk oxide dielectric. In both the SL and ML cases, oxide trapped holes compete with interface trapped electrons, exhibiting an overall shift toward negative gate bias. Raman spectroscopy shows no variation in the MoS2 signatures as a result of VUV exposure, eliminating significant crystalline damage or oxidation as possible radiation degradation mechanisms. Overall, this work presents avenues for achieving radiation-hard MoS2 devices through dielectric engineering that reduces oxide and interface trapped charge.
High-Resolution Bio-potential and Bio-impedance Investigation of the Face (2023)

Abstract The importance of facial muscles is evident in the critical role they play in numerous functions. The purpose of some actions (e.g. chewing, swallowing) is clear. Others, such as yawning and the expression of emotion are more elusive. Despite their ubiquity, the manner by which facial muscles affect physiological processes is not clear. In particular, how facial muscles affect blood flow has received little attention. Here we present a new wearable approach to investigate the face. Soft electrode arrays were used to detect subtle changes in blood flow in the temporal superficial artery following muscle activity. Changes in response to muscle activation are clearly evident and conspicuously more complex than in the forearm. Simultaneous bio-potential and bio-impedance mapping of the face unravels the complex manner by which these muscles help shape human physiology.
The cloud will change everything (2011)

Cloud computing is fast on its way to becoming a meaningless, oversold marketing slogan. In the midst of this hype, it is easy to overlook the fundamental change that is occurring. Computation, which used to be confined to the machine beside your desk, is increasingly centralized in vast shared facilities and at the same time liberated by battery-powered, wireless devices. Performance, security, and reliability are no longer problems that can be considered in isolation -- the wires and software connecting pieces offer more challenges and opportunities than components themselves. The eXtreme Computing Group (XCG) in Microsoft Research is taking a holistic approach to research in this area, by bring together researchers and developers with expertise in data center design, computer architecture, operating systems, computer security, programming language, mobile computation, and user interfaces to tackle the challenges of cloud computing.
Roughness measurement of 2D curvilinear patterns: challenges and advanced methodology (2021)

International audience
Mapping the Interactions among Biomaterials, Adsorbed Proteins, and Human Embryonic Stem Cells (2009)

An integrated high-throughput polymer synthesis and rapid material/protein/cell interaction assays were developed to optimize stem cell microenvironments. Microarrayed polymers were synthesized and studied for the ability to support the growth of partially differentiated human embryonic stem cells. In parallel, a programmed laser scanning cytometry system was developed to allow for rapid quantification of cell material interaction. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Les petites protéines G de la famille Rho (2002)

Les proteines Rho appartiennent a la superfamille Ras des proteines G de faible masse moleculaire. Elles jouent le role de commutateurs moleculaires dans la transmission des signaux intracellulaires, controlant ainsi de nombreux processus biologiques. Elles alternent entre une forme inactive liee au GDP et une forme active liee au GTP. Ce cycle est regule par differentes classe de proteines, les GEFS, facteurs d'echanges des nucleotides, les GAP, activateurs de l'activite GTPasique intrinseque et les GDI, inhibiteurs de la dissociation du GDP. Les proteines Rho sont non seulement regulees au niveau de l'echange GDP/GTP, mais subissent egalement une etape de prenylation (farnesylation ou geranylgeranylation) maturation post-traductionnelle necessaire a leur localisation subcellulaire et a leur activite biologique. Les proteines Rho activent un certain nombre d'effecteurs et des voies de signalisation cellulaire qui interviennent plus ou moins specifiquement dans chacun de leur role biologique. Elles jouent un role essentiel dans l'organisation du cytosquelette d'actine, assurant ainsi la motilite, l'adhesion au substratum et intercellulaire, la contraction et la cytodierese. Plus recemment leur role essentiel dans le controle de la proliferation et la differenciation cellulaires, mais aussi la transformation ainsi que l'invasion a ete mis en evidence. La revue se focalise essentiellement sur les proteines RhoA, Rac1 et Cdc42 qui ont ete jusqu'a present les plus etudiees.
Tin Halide Perovskite Films Made of Highly Oriented 2D Crystals Enable More Efficient and Stable Lead-free Perovskite Solar Cells (2020)

Low toxicity and an ideal energy bandgap make two-dimensional (2D) Ruddlesden–Popper tin-based halide perovskites a promising photovoltaic material. However, the disordered crystal orientation and the oxidation of Sn2+ to Sn4+ still need to be addressed. Here, we demonstrate that the annealing of FASnI3 assisted by phenyl ethylammonium chloride enables the formation of more ordered 2D tin-based perovskite crystals oriented vertically. We use in situ synchrotron-based grazing incident X-ray diffraction to correlate the higher crystal orientation to the better device performance. We measured a maximum power conversion efficiency of more than 9%. Furthermore, we demonstrate that the phenyl ethylammonium chloride acts as a barrier layer at the surface of the crystals protecting the tin from the oxidation. Hence, this work paves the way for more efficient and stable lead-free perovskite solar cells.
Increased survival in hepatitis c patients who underwent living donor liver transplant: a case-control study with propensity score matching (2017)

LDLT appears to be suitable for HCV-infected patients if appropriate living donor is available.
Medication Injection Safety Knowledge and Practices Among Anesthesiologists (2014)

Gounder, Prabhu; Beers, Richard; Bornschlegel, Katherine; Hinterland, Kinjia; Balter, Sharon Author Information
Actor Conditioned Attention Maps for Video Action Detection (2020)

While observing complex events with multiple actors, humans do not assess each actor separately, but infer from the context. The surrounding context provides essential information for understanding actions. To this end, we propose to replace region of interest(RoI) pooling with an attention module, which ranks each spatio-temporal region's relevance to a detected actor instead of cropping. We refer to these as Actor-Conditioned Attention Maps (ACAM), which amplify/dampen the features extracted from the entire scene. The resulting actor-conditioned features focus the model on regions that are relevant to the conditioned actor. For actor localization, we leverage pre-trained object detectors, which transfer better. The proposed model is efficient and our action detection pipeline achieves near real-time performance. Experimental results on AVA 2.1 and JHMDB demonstrate the effectiveness of attention maps, with improvements of 7 mAP on AVA and 4 mAP on JHMDB.
Tumor-suppressive activities by chemokines introduced into OV-HM cells using fiber-mutant adenovirus vectors. (2004)

In this study, fiber-mutant adenovirus vectors encoding chemokines, Ad-RGD-mCCL17, Ad-RGD-mCCL21 and Ad-RGD-mCCL22 were constructed. The insertion of integrin-targeting RGD sequence into fiber knob of adenovirus vectors notably enhanced the infection efficiency into tumor cells. Among three chemokine-encoding vectors evaluated, Ad-RGD-mCCL22 showed significant tumor-suppressive activity via transduction into OV-HM cells.
The Leukotriene Receptor Antagonist Montelukast as a Potential COVID-19 Therapeutic (2020)

The emergence and global impact of COVID-19 has focused the scientific and medical community on the pivotal influential role of respiratory viruses as causes of severe pneumonia, on the understanding of the underlying pathomechanisms, and on potential treatment for COVID-19. The latter concentrates on <i>four</i> different strategies: (i) antiviral treatments to limit the entry of the virus into the cell and its propagation, (ii) anti-inflammatory treatment to reduce the impact of COVID-19 associated inflammation and cytokine storm, (iii) treatment using cardiovascular medication to reduce COVID-19 associated thrombosis and vascular damage, and (iv) treatment to reduce the COVID-19 associated lung injury. Ideally, effective COVID-19 treatment should target as many of these mechanisms as possible arguing for the search of common denominators as potential drug targets. Leukotrienes and their receptors qualify as such targets: they are lipid mediators of inflammation and tissue damage and well-established targets in respiratory diseases like asthma. Besides their role in inflammation, they are involved in various other aspects of lung pathologies like vascular damage, thrombosis, and fibrotic response, in brain and retinal damages, and in cardiovascular disease. In consequence, leukotriene receptor antagonists might be potential candidates for COVID-19 therapeutics. This review summarizes the current knowledge on the potential involvement of leukotrienes in COVID-19, and the rational for the use of the leukotriene receptor antagonist montelukast as a COVID-19 therapeutic.
Longitudinal Model of Periprosthetic Joint Infection in the Rat (2019)

The majority of periprosthetic joint infections occur shortly after primary joint replacement (<3 months) and require the removal of all implant components for the treatment period (~4 months). A clinically relevant animal model of periprosthetic infection should, therefore, establish an infection with implant components in place. Here, we describe a joint replacement model in the rat with ultrahigh molecular weight polyethylene (UHMWPE) and titanium components inoculated at the time of surgery by methicillin-sensitive Staphylococcus aureus (S. aureus), which is one of the main causative microorganisms of periprosthetic joint infections. We monitored the animals for 4 weeks by measuring gait, weight-bearing symmetry, von Frey testing, and micro-CT as our primary endpoint analyses. We also assessed the infection ex vivo using colony counts on the implant surfaces and histology of the surrounding tissues. The results confirmed the presence of a local infection for 4 weeks with osteolysis, loosening of the implants, and clinical infection indicators such as redness, swelling, and increased temperature. The utility of specific gait analysis parameters, especially temporal symmetry, hindlimb duty factor imbalance, and phase dispersion was identified in this model for assessing the longitudinal progression of the infection, and these metrics correlated with weight-bearing asymmetry. We propose to use this model to study the efficacy of using different local delivery regimens of antimicrobials on addressing periprosthetic joint infections. Statement of clinical significance: We have established a preclinical joint surgery model, in which postoperative recovery can be monitored over a multi-week course by assessing gait, weight-bearing, and allodynia. This model can be used to study the efficacy of different combinations of implant materials and medication regimens. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:1101-1112, 2020.
Automated extraction and classification of RNA tertiary structure cyclic motifs (2006)

A minimum cycle basis of the tertiary structure of a large ribosomal subunit (LSU) X-ray crystal structure was analyzed. Most cycles are small, as they are composed of 3- to 5 nt, and repeated across the LSU tertiary structure. We used hierarchical clustering to quantify and classify the 4 nt cycles. One class is defined by the GNRA tetraloop motif. The inspection of the GNRA class revealed peculiar instances in sequence. First is the presence of UA, CA, UC and CC base pairs that substitute the usual sheared GA base pair. Second is the revelation of GNR(X(n))A tetraloops, where X(n) is bulged out of the classical GNRA structure, and of GN/RA formed by the two strands of interior-loops. We were able to unambiguously characterize the cycle classes using base stacking and base pairing annotations. The cycles identified correspond to small and cyclic motifs that compose most of the LSU RNA tertiary structure and contribute to its thermodynamic stability. Consequently, the RNA minimum cycles could well be used as the basic elements of RNA tertiary structure prediction methods.
IR emitting quantum dots for defense applications (2013)

QD Vision has developed Quantum Dot Light Emitting Devices whose emission spans the wavelength range from 1000 nm to 1.35 &mu;m, using tunable, narrow band quantum dot emission. These devices emit sufficient power for long range-detection by a variety of systems, run at very low drive voltages, and are producible in area emitting form-factors that are very thin and light weight. Potential applications for these devices include covert illumination, tagging, display backlighting, and line-of-sight communications. In this paper, we demonstrate electrically driven quantum dot light emitting devices that emit in the wavelength range of 1000 nm to 1.35 &mu;m, with full-widths at half-maximum as low as 128 nm. The devices discussed are characterized with respect to their efficiency, power output, and lifetime, and this data is used to evaluate their suitability for use in a variety of defense-related applications. Example devices are discussed, including completed prototypes 1.5mm thick with active areas up to 4 cm<sup>2</sup>. Experimental results are presented that demonstrate a low turn-on voltage of 1.4 V, a maximum external quantum efficiency of 2.5 %, a power efficiency of 25 mW/W, and a peak radiance of 18.3 W/sr.m<sup>2</sup>. Lifetimes of more than 1000 hours at operating drive levels are also shown.
Abstract 19607: Mechano-Chronotropic Unloading in the Acute Phase of Myocardial Infarction Strikingly Reduces Infarct Size and Prevents Heart Failure in the Long-Term (2017)

Introduction: Myocardial infarction (MI) remains a leading cause of chronic heart failure (CHF). Presence of unsalvaged myocardium leads to cardiac remodeling and CHF. Reducing myocardial oxygen co...
New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: evidence from a core dataset of 2124 patients (2007)

We have generated a large, unique database that includes morphologic, clinical, cytogenetic, and follow-up data from 2124 patients with myelodysplastic syndromes (MDSs) at 4 institutions in Austria and 4 in Germany. Cytogenetic analyses were successfully performed in 2072 (97.6%) patients, revealing clonal abnormalities in 1084 (52.3%) patients. Numeric and structural chromosomal abnormalities were documented for each patient and subdivided further according to the number of additional abnormalities. Thus, 684 different cytogenetic categories were identified. The impact of the karyotype on the natural course of the disease was studied in 1286 patients treated with supportive care only. Median survival was 53.4 months for patients with normal karyotypes (n = 612) and 8.7 months for those with complex anomalies (n = 166). A total of 13 rare abnormalities were identified with good (+1/+1q, t(1q), t(7q), del(9q), del(12p), chromosome 15 anomalies, t(17q), monosomy 21, trisomy 21, and -X), intermediate (del(11q), chromosome 19 anomalies), or poor (t(5q)) prognostic impact, respectively. The prognostic relevance of additional abnormalities varied considerably depending on the chromosomes affected. For all World Health Organization (WHO) and French-American-British (FAB) classification system subtypes, the karyotype provided additional prognostic information. Our analyses offer new insights into the prognostic significance of rare chromosomal abnormalities and specific karyotypic combinations in MDS.
Comprehensive analysis of the metabolome of Pseudomonas putida S12 grown on different carbon sources (2008)

Metabolomics is an emerging, powerful, functional genomics technology that involves the comparative non-targeted analysis of the complete set of metabolites in an organism. We have set-up a robust quantitative metabolomics platform that allows the analysis of 'snapshot' metabolomes. In this study, we have applied this platform for the comprehensive analysis of the metabolite composition of Pseudomonas putida S12 grown on four different carbon sources, i.e. fructose, glucose, gluconate and succinate. This paper focuses on the microbial aspects of analyzing comprehensive metabolomes, and demonstrates that metabolomes can be analyzed reliably. The technical (i.e. sample work-up and analytical) reproducibility was on average 10%, while the biological reproducibility was approximately 40%. Moreover, the energy charge values of the microbial samples generated were determined, and indicated that no biotic or abiotic changes had occurred during sample work-up and analysis. In general, the metabolites present and their concentrations were very similar after growth on the different carbon sources. However, specific metabolites showed large differences in concentration, especially the intermediates involved in the degradation of the carbon sources studied. Principal component discriminant analysis was applied to identify metabolites that are specific for, i.e. not necessarily the metabolites that show those largest differences in concentration, cells grown on either of these four carbon sources. For selected enzymatic reactions, i.e. the glucose-6-phosphate isomerase, triosephosphate isomerase and phosphoglyceromutase reactions, the apparent equilibrium constants (K(app)) were calculated. In several instances a carbon source-dependent deviation between the apparent equilibrium constant (K(app)) and the thermodynamic equilibrium constant (K(eq)) was observed, hinting towards a potential point of metabolic regulation or towards bottlenecks in biosynthesis routes. For glucose-6-phosphate isomerase and phosphoglyceromutase, the K(app) was larger than K(eq), and the results suggested that the specific enzymatic activities of these two enzymes were too low to reach the thermodynamic equilibrium in growing cells. In contrast, with triosephosphate isomerase the K(app) was smaller than K(eq), and the results suggested that this enzyme is kinetically controlled.
Synthèse Totale de Produits Naturels Macrocycliques Biologiquement Actifs (1998)

LSPN
Erratum: “Effect of size and roughness on light transmission in a Si/SiO2 waveguide: Experiments and model” [Appl. Phys. Lett. 77, 1617 (2000)] (2000)

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