gebhart/patrepeval huggingface dataset:
Abstract B04: Palbociclib-based combinatorial drug screening in ER-positive cell lines identifies efficacious single agents and novel combinations with synergistic interactions (2018)

Abstract Estrogen receptor (ER)-positive breast cancer is associated with a good prognosis, but when ER+ breast tumors progress, treatment options are limited. The combination of the CDK inhibitor palbociclib plus the ER degrader fulvestrant was recently approved for patients who have recurrences of ER+ disease. However, durable responses are not typically seen with this combination, and patients eventually progress on therapy. We sought to test other drug combinations using palbociclib as the backbone of therapy. We tested 13 different FDA-approved drugs in combination with palbocilib in a panel of 7 ER+ breast cancer cell lines (600MPE, MDAMB134vii, MDAMB415, ZR75-1, ZR75B, and MCF7). Molecularly, all lines were characterized by amplification of the CCND1 region, high levels of expression of ER, and low RNA expression of EGFR. CAMA1 showed general resistance to the drugs used, never reaching a GR50 (growth rate inhibition of 50%) even at the highest dose tested with palbociclib. CAMA1 was also resistant to the majority of the other 13 drugs, with the exception of panobinostat, vorinostat, and everolimus. Across the entire cell line set, these three compounds were the most effective as single agents. For example, the HDAC inhibitors panobinostat and vorinostat had low nanomolar GR50 values in 7/7 and 4/7 cell lines, respectively. However, significant antagonism was observed between both HDAC inhibitors and palbociclib in MCF7, ZR75B, and ZR75-1, indicating that combining these agents may not be clinically effective. Everolimus plus palbociclib and trametinib plus palbociclib combinations were significantly synergistic in 3/7 cell lines (600MPE, ZR75B, and MCF7 in both cases). Interestingly, CAMA1 and MDAMB134 never showed any evidence of synergistic interactions with any of the combinations tested, suggesting that they may be a distinct subset of ER+ breast cancers. This study indicates that HDAC inhibitors may be effective for treating ER+ tumors that have progressed on antiestrogen therapy, and that combinations of palbociclib plus everolimus or trametinib may also have efficacy. Citation Format: Rebecca Smith, Tiera Liby, Joe Gray, James Korkola. Palbociclib-based combinatorial drug screening in ER-positive cell lines identifies efficacious single agents and novel combinations with synergistic interactions [abstract]. In: Proceedings of the AACR Special Conference: Advances in Breast Cancer Research; 2017 Oct 7-10; Hollywood, CA. Philadelphia (PA): AACR; Mol Cancer Res 2018;16(8_Suppl):Abstract nr B04.
The impact of the Q-factor of the parasitic capacitances of RF transistors on their load modulation capabilities (2014)

With the high number of users the wireless spectrum has become a valuable resource. In order to use it efficiently sophisticated coding schemes with high crest factors are used. As a result the power amplifier is operated far below maximum output power for most of the time, which results in rather low efficiency of traditional designs. Therefore efficiency enhancement methods such as the Doherty or Chireix combiner are experiencing a revival. Their performance heavily depends on the load modulation properties of the used RF transistors and unfortunately often falls behind the predicted theory, especially for high frequency operation. This paper analyses the impact of the different loss mechanisms of RF power transistors on their load modulation capabilities. Special attention was paid to the frequency dependent losses due to the limited Q-factor of the parasitic capacitance. Based on the example of a Doherty amplifier the importance of the load modulation properties for the efficiency in back off is highlighted.
Selbstorganisation eines tetraedrischen Lectins zu einem vorab entworfenen, diamantähnlichen Proteinkristall (1999)

Wie bei sp3-Hybridisierung angeordnete Bindungsstellen weist Concanavalin A auf. Dieses Lectin konnte nun mit einem Bismannopyranosid vernetzt werden, dessen C2-Spacer die Bildung des gezeigten computermodellierten, diamantartigen dreidimensionalen Proteingitters ermöglichte.
OUTformation: Distributed Data-Gathering with Feedback under Unknown Environment and Communication Delay Constraints (2022)

Towards the informed design of large-scale distributed data-gathering architectures under real-world assumptions such as nonzero communication delays and unknown environment dynamics, this paper considers the effects of allowing feedback communication from the central processor to external sensors. Using simple but representative state-estimation examples, we investigate fundamental tradeoffs between the mean-squared error (MSE) of the central processor's estimate of the environment state, and the total power expenditure per sensor under more conventional architectures without feedback (INformation) versus those with broadcast feedback (OUTformation). The primary advantage of enabling feedback is that each sensor's understanding of the central processor's estimate improves, which enables each sensor to determine when and what parts of its current observations to transmit. We use theory to demonstrate conditions in which OUTformation maintains the same MSE as INformation with less power expended on average, and conditions in which OUTformation obtains less MSE than INformation at additional power cost. These performance tradeoffs are also considered under settings where environments undergo less variation, and sensors implement random backoff times to prevent transmission collisions. Our results are supported via numerical studies, which show that the properties derived in theory still hold even when some of the simplifying assumptions are removed.
Kinetic and Thermodynamic Studies for Methylene Blue Adsorption using Activated Carbon Prepared from Agricultural and Municipal Solid Wastes (2013)

This study aimed to evaluate and optimize the removal of methylene blue onto low cost starting material activated carbon. The effects of pH, contact time, initial concentration on adsorption process were investigated. Results showed that effective adsorption was occurred in the pH range of 5-12. The maximum adsorption capacity (140.03 mg/g) was obtained at contact time 480 min, at initial methylene blue concentration of 150 ppm. Adsorption kinetics of methylene blue was analyzed by pseudo first order, pseudo second order and intraparticle diffusion models. Results showed that methylene blue adsorption onto activated carbon followed second order kinetics models most appropriately. Thermodynamic parameters; DGº, DHº and DSº indicate that the sorption process was spontaneous and endothermic in nature. The magnitude of DGº was -6.27 to -12 kJ/mol, the standard enthalpy and the entropy values in the range of 25-50 ºC were obtained as 44.13 kJ mol-1 and 158.3 kJ mol-1 K-1.
Generic protocol for accessing content discovery metadata in advanced IPTV systems (2011)

Content discovery metadata is one of the foremost important issues in any IPTV standard. Different IPTV standards have specific protocols to access (including update) the metadata database of their specific schemas. In this paper, we present a generic protocol that enables an IPTV device to access discovery metadata of different schemas. This approach also supports the evolution of metadata schemas in the future.
Saccharomyces Cerevisiae SPT3 Gene is Required for Transposition and Transpositional Recombination of Chromosomal Ty Elements (1986)

Mutations in the Saccharomyces cerevisiae SPT3 gene have dramatic effects on the expression of Ty elements and genes adjacent to the element. The SPT3 gene is essential for Ty transposition, because transposition of chromosomal Ty elements ceased when the SPT3 gene was replaced with the frameshift mutation spt3-101. Presumably, the elimination of transposition was due to the effect of the SPT3 gene product on Ty transcription; the transcripts of chromosomal Ty elements were largely abolished in the spt3-101 strain (F. Winston, K. J. Durbin, and G. R. Fink, Cell 39:675-682, 1984). Ty transcription in an spt3-101 strain could be reestablished by introduction of the pGTyH3 plasmid, in which transcription of the Ty element TyH3 is under the control of the GAL1 promoter; these plasmid-derived Ty transcripts were SPT3-independent. Ty transposition resumed after galactose induction in spt3-101 strains containing the pGTyH3 plasmid. In spt3 mutants nearly all of the resulting transposition events derived from pGTyH3 plasmids and not from chromosomal elements.
Practicalities and Analysis of Using PTP over 5G Systems with Dedicated Time Synchronization Support for Media Production (2022)

The 5G system is becoming more and more a multi-purpose wireless network. Several industry verticals have started using 5G networking technology for their purposes. 3GPP has defined a set of dedicated features relevant to one or more industry verticals. These new features make 5G more suitable for different media production scenarios, such as remote production or mobile studio scenarios, extending the local OB Van facilities and replacing the traditional RF cameras. 5G systems support bi-directional communication by nature, using Time Division Duplex (TDD) or Frequency Division Duplex (FDD). This would allow replacing multiple existing RF transmitters and receivers with a single RF solution. Further, the 5G radio network simultaneously shares the available spectrum with many devices by scheduling small radio resource units. However, some of these 5G systems concepts can become tricky to use for high-performance media over IP due to inherited jitter (due to scheduling and TDD), throughput variations, and path asymmetries (due to capacity allocation for uplink and downlink). The time synchronization between media sources can be challenging in 5G environments due to varying latencies of the radio transmissions. The paper explores the possibility of using IEEE 1588, Precision Time Protocol over a 5G system for media production applications. With 3GPP TS 23.501 Release 16, the 5G System specifications started to include dedicated time synchronization support. 3GPP Release 16 added specific time synchronization support for Time-Sensitive Networks (TSN), i.e., acting as a Time-aware system. With 3GPP Release 17, the support for IEEE 1588 is extended with several additional features. It becomes possible to use PTP according to the SMPTE ST 2059-2 PTP Profile reliably over 5G for media device synchronization. The paper describes lab sessions performed by the 5G RECORDS consortium members, testing the performance of PTP over 5G with and without the dedicated time synchronization support. A trial with a real camera supporting SMPTE ST 2110-22 with JPEG XS was conducted to experiment with synchronization and packet pacing precision. The paper also describes the testing setup based on the open-sourced software used by the team and the methodology developed. The paper concludes on the performance and synchronization quality when using PTP over various 5G systems and analyzes the results from the lab trials.
Induced Seismology and Hydrocarbon Production (2007)

Abstract Microseismicity generated during hydraulic fracturing operations provides information tooptimize stimulation design,direct treatment operations, andmore effectively manage the stimulated reservoir by understanding the dimensions of the treatment footprint. Microseismic monitoring technique is applicable to all reservoirs requiring hydraulic stimulation to assure commercial productivity. Geophysics moves beyond mere reflection seismic to applying the principles of earthquake seismology to address issues related to hydraulic fracture stimulation and reservoir management. Introduction Microseimic techniques have been used to map hydraulic fracturing operations since the mid-1980s. The method received curious stares until the seminal works in the mid- to late-1990s at the M-Site near Rulison, Coloradoand the Cotton Valley Field in Texasbegan appearing in industry publications. Commercial interest in the technology heightened, and is now offered by several service companies, typically using systems originally built for recording vertical seismic profiles. Entire sections are now devoted to microseismic monitoring of hydraulic fracture operations at the international conferences for both engineering and geophysics. As a business in the United States, it is estimated that microseismic monitoring of hydraulic fracturing operations has grown from a few dozen wells in 2002 to over 600 wells monitored in 2006 (Figure 1). Moreover, the number of stages being monitored has grown from just over one stage per well to more than three stages being monitored per well. The staggering growth of this technology highlights both its broad acceptance in industry, as well as the great need for the information it provides, especially in horizontal wells. Applications Microseismic hydraulic fracture monitoring (MHFM) demonstrates value to the operator in three distinct applications: fracture treatment diagnostics, fracture treatment control, and reservoir management. The locations of the microseismic events are displayed in 3D volumes, minimally with sketches of the treatment well and observation well to provide geometrical context (Figure 2). Fracture Treatment Diagnostics The use of MHFM for fracture treatment diagnostics seeks to answer two main questions:How did the treatment perform versus design?What parameters or assumptions need to be changed to achieve a higher performing treatment design? Weak assumptions of symmetry, rock properties, and treatment pressure interpretation often lead to an improper analysis of treatment performance. The MHFM data provides measured context for understanding the treatment behavior and performance. The MHFM results constrain the possible interpretation of the treatment data, and can lead to more productive treatment designs (3) (Figure 3). Fracture Treatment Control MHFM operations can provide valuable real-time control information for the treatment operations. The questions MHFM can answer are:How well is the treatment being contained?When should pumping stop due to terminating mechanical growth or geological concerns?
Total organic halogen (TOX) species formation at different locations in drinking water distribution systems (2020)

TOCl, TOBr and TOI concentrations were quantified quarterly at 11 US drinking water treatment plants and distribution systems.
Blood Transcriptional Correlates of BCG-Induced Protection Against Tuberculosis in Rhesus Macaques (2022)

SUMMARY Blood-based correlates of vaccine-induced protection against tuberculosis (TB) are urgently needed. We analyzed the blood transcriptome of rhesus macaques immunized with varying doses of intravenous (IV) BCG followed by Mycobacterium tuberculosis ( Mtb ) challenge. We used high-dose IV BCG recipients for “discovery” and validated our findings in low-dose recipients and in an independent cohort of macaques receiving BCG via different routes. We identified seven vaccine-induced gene modules, including an innate module (module 1) enriched for type 1 interferon and RIG-I-like receptor signaling pathways. Module 1 on day 2 post-vaccination was highly correlated with lung antigen-responsive CD4 T cells at week 8 and with Mtb and granuloma burden following challenge. Parsimonious signatures within module 1 at day 2 post-vaccination predicted protection following challenge with AUROCs ≥ 0.91. Together these results indicate that the early innate transcriptional response to IV BCG in peripheral blood may provide a robust correlate of protection against TB.
Abstract 163: Delayed Administration of Perlecan Doman V Significantly Increases Neurogenesis and Improves Functional Outcome after Experimental Ischemic Stroke (2015)

Stroke, a major cause of significant morbidity and death, has limited therapeutic options. To that end, our goal is to develop novel stroke therapies by exploiting the brain’s own neuroreparative potential. We have discovered that perlecan, a prominent brain extracellular matrix proteoglycan, is proteolyzed into the bioactive protein fragment domain V (DV) after experimental and human ischemic stroke. DV is both neuroprotective and pro-angiogenic. Furthermore, functional outcome can be significantly improved in rodents by administering DV 6-24 hours after experimental transient (distal MCA occlusion) or permanent (photothrombosis) stroke. Here we studied in mechanistic detail whether delayed DV administration (initiated 7 days post-stroke) could increase neurogenesis and improve functional outcome after mouse transient MCA occlusion. Delayed DV administration also served to minimize confounding neuroprotective and angiogenic effects which occur with acute DV therapy. After two doses of DV (post-stroke day 7 and 9), stroked 3-month old male C57BL6 mice had significant functional improvement (rotor rod) compared to vehicle treated stroke controls. Brain immunohistochemistry 21 days after stroke demonstrated that DV treated mice had significantly more cells that were positive for BrdU (a marker of cell division), doublecortin (DCX, a marker for immature neurons), and NeuN (another neuronal marker) in the infarct area. Furthermore, stereotactic brain injection (AP + 0.00, ML - 1.2, DV – 2.5) with alpha 2 integrin (a known neuronal DV receptor) function blocking antibody on post-stroke day 3 inhibited DV’s post-stroke neurogenic effects. These results suggest that delayed DV treatment after experimental stroke increases neurogenesis, increases the number of new neurons that reach stroked brain regions and survive there, and improves functional outcome through an alpha 2 integrin dependent mechanism. Importantly, as we are unaware of any other delayed treatment other than FLAME clinical trial (fluoxetine treatment initiated 5-10 days after stroke) that significantly improves functional outcome after stroke, our data further suggest the promise of DV as an effective stroke therapy.
Long-term survival of medically treated patients in the Coronary Artery Surgery Study (CASS) Registry. (1994)

These results contribute to the understanding of the natural history of coronary artery disease and are also of historical interest. The poor survival of patients with three-vessel disease and low ejection fractions continues to emphasize the importance of considering revascularization for these patients.
HVAD Flow Waveform Morphologies: Theoretical Foundation and Implications for Clinical Practice (2017)

Continuous-flow ventricular assist device (cfVAD) performance and patient hemodynamic conditions are intimately interrelated and dynamic, changing frequently with alterations in physiologic conditions, particularly pre- and afterloading conditions. The Heartware cfVAD (HVAD) provides a unique feature among currently approved VADs of providing an estimated instantaneous flow waveform, the characteristics of which can provide significant insights into patient and device properties. Despite being readily available, HVAD waveforms are poorly understood, underutilized, and insufficiently leveraged, even by clinicians who regularly manage HVAD patients. The purpose of this review is to provide the theoretical foundation for understanding the determinants of HVAD waveform characteristics and to provide practical examples illustrating how to interpret and integrate changes of HVAD waveforms into clinical practice. Heartware cfVAD waveforms should be considered a complimentary tool for the optimization of medical therapies and device speed in HVAD patients.
Characterization of Antibodies to the Structural Polypeptides of HBsAg: Evidence for Subtype-Specific Determinants (1976)

Summary Antisera prepared in guinea pigs to the structural polypeptides of HBsAg/adw and HBsAg/ayw were examined by a modified passive hemagglutination assay for antibodies to the subtype-specific d and y determinants. All of the isolated polypeptide fractions stimulated antibodies to both group-specific and subtype-specific antigens of the native HBsAg particle from which they were derived. These data indicate that the polypeptides have similarities in their immunochemical structure.
<title>Tracking and imaging humans on heterogeneous infrared sensor arrays for law enforcement applications</title> (2002)

We present a plan for the integration of geometric constraints in the source, sensor and analysis levels of sensor networks. The goal of geometric analysis is to reduce the dimensionality and complexity of distributed sensor data analysis so as to achieve real-time recognition and response to significant events. Application scenarios include biometric tracking of individuals, counting and analysis of individuals in groups of humans and distributed sentient environments. We are particularly interested in using this approach to provide networks of low cost point detectors, such as infrared motion detectors, with complex imaging capabilities. By extending the capabilities of simple sensors, we expect to reduce the cost of perimeter and site security applications.
Self-focusing of an intense ultra- and hypersonic beam in an inhomogeneous and absorbing solid (1977)

The behaviour of ultra- and hypersonic ray beams in an inhomogeneous and absorbing solid medium is investigated. The inhomogeneities are supposed to be of local character. The absorption of a sound wave by these local inhomogeneities results in the formation of heat “haloes” formed around them. The analysis of the expression obtained for the scattering section shows that under certain conditions self-focusing in an inhomogeneous and absorbing solid medium is possible (in principle). Some calculations of characteristic parameter values are given at which self-focusing of the sound wave is possible. Le présent travail envisage l'étude de la conduite des faisseaux ultras et hypersoniques hétérogéne absorbés par un méédium solide. L'hétérogénéité est présumée porter un caractére local. L'absorbtion de l'onde sonore par ces hétérogénéités locales, entraǐne la formation des oréoles de chaleur autour d'elles. L'analyse de l'expression obtenue de la diffusion des ondes de la section montre, que sous certaines conditions, il est possible (en principe) l'automise au point des hétérogénéités et celle du médium solide. La particularité de certaines valeurs caractéristiques obtenues des paramétres, donne la possibilité d'automise au point aux ondes sonores.