gebhart/patrepeval huggingface dataset:
Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans (2018)

By disruption of LaeB, a global regulator recently characterized in Aspergillus nidulans, eight cryptic compounds in the mutant were identified, including seven polyketides and one NRPS-like product. Among the isolates, two phthalides and two dibenzo[1,4]dioxins are new compounds, revealing that the genetic manipulation of the global regulator represents a promising approach for the discovery of novel natural products in fungi.
Isolation and Partial Characterization of an Entero-Oxyntin from Porcine Ileum* (1984)

Porcine ileal mucosa was homogenized and freeze-thawed in 0.05 M NH4HCO3 + 0.01 M EDTA + 1 mM benzamidine hydrochloride at pH 8.6. Subsequent stepwise precipitation with (NH4)2SO4 followed by fractionation on Sephadex G-50 medium and G-50 fine eluted with alkaline buffer and final fractionation on G-50 superfine in 1.0 M acetic acid yielded a pure protein of 13,000 daltons as determined by sodium dodecyl sulfate electrophoresis. The amino acid composition of the protein has been determined and it contains 126 residues with no tryptophan detectable. Tryptic peptide maps demonstrate that the protein does not contain glucagon and RIA of the peptide did not detect any immunoreactive glucagon or gastrin. The isoelectric point is 6.4. The intact protein is resistant to Edman degradation and the partial N-terminal sequences of two CNBr fragments are: Lys-Arg-Leu-Ala-Leu ...., Glu-Gly-Gly-Thr-Val-Val-Val-Asn-Ser.... The C-terminal residue, alanine was determined using carboxypeptidase Y. The isolated peptide, in the range of 10(-15)-10(-9) M stimulated oxyntic cell hydroxyl ion production in sections of guinea pig gastric fundus. The dose response was linear with biphasic peaks at 10(-14) and 10(-9) M and the maximal response to the peptide was equal to that observed with gastrin. The addition of either atropine (10(-5) M) or cimetidine (10(-5) M) with the peptide (10(-14) M) caused greater than 50% inhibition of oxyntic cell stimulation (P less than 0.005). This peptide is a potent stimulator of the oxyntic cell and its effect is inhibited by muscarinic cholinergic and H2 receptor blockers. Hence, it represents a significant component of the physiological enterooxyntin effect observed in response to intestinal meals.
Electroless Copper Bonding with Local Suppression for Void-Free Chip-to-Package Connections (2012)

The effect of bis-(3-sulfopropyl)-disulfide (SPS) on the void-free electroless pillar-to-pillar bonding process has been investigated. Two dome-shaped Cu pillars were joined using electroless copper deposition with the addition of a suppressor to achieve solid, compliant Cu-to-Cu bonding without high temperature or pressure. SPS was added to the electroless copper plating bath which has strong suppression to the electroless plating in order to avoid the creation of an unbonded seam between the two Cu structures being bonded. The bath suppresses the deposition of copper near the entrance of the gap between the two pillars, while allowing high deposition rate in the geometrically restricted area between the copper structures being bonded. This phenomenon is due to diffusion of SPS through the narrow gap between the pillars being bonded. At adequate concentration of SPS, the two pillars were successfully joined without any remaining seam between the joined structures, by growth of copper from the center of the gap to the outside.
Data collection of biomedical data and sensing information in smart rooms (2023)

This paper presents a new dataset, including behavioral, biometric, and environmental data, obtained from 23 subjects each spending 1 week to 2 months in smart rooms in Tokyo, Japan. The approximate duration of the experiment is 2 years. This dataset includes personal data, such as the use of home appliances, heartbeat rate, sleep status, temperature, and illumination. Although there are many datasets that publish these data individually, datasets that publish them all at once, tied to individual pseudo IDs, are valuable. The number of days for which data were obtained was 488, the number of records was 18,418,359, and the total size of the obtained data was 2.76 GB. This dataset can be used for machine learning and analysis for tips on getting a good night's sleep, for example.
A Scaled-2D CNN for Skin Cancer Diagnosis (2021)

Every year, doctors diagnose skin cancer in around 3 million or more patients across the globe. Currently, it is one of the most widely recognized kinds of cancers for human health. Hence, we need an early diagnosis to prevail any critical condition of the infected patients. Apparently, it can treat with topical drugs, if it diagnoses in an early stage. Hence as an outcome, skin cancer is responsible for less than 1% of all cancer deaths. There are two types of tumors in the skin cancer diseases domain, such as benign and malignant. To develop a robust and early screening system to diagnose skin cancer, it requires an efficient algorithm for prediction, trained with a large dataset. The primary aim of this research is to develop an efficient skin cancer screening process using a robust deep neural network with a large dataset. In this paper, we intend to determine considerate and dangerous types of skin cancer tumors using dermoscopic images from a publicly available dataset. We proposed an efficient and fast scaled 2D-CNN based on EfficientNet-B7 deep neural architecture with image preprocessing. This paper also uses two different pre-trained deep neural architectures, such as VGG19, and ResNet-50 to compare the performance with the proposed architecture. The proposed architecture outperformed the other pre-trained CNN models whereas the proposed architecture achieved higher AUC and accuracy compared to other architectures.
ChemInform Abstract: Photochromism of Spiropyrans in Aluminosilicate Gels. (1990)

Abstract The photochromism of spiropyrans (I) is studied by transient absorption and luminescence spectroscopy.
A flexible fast spin echo triple‐echo Dixon technique (2016)

The flexible FTED technique incorporates the benefits of both FSE and Dixon imaging and provided more flexibility than the original FTED in applications such as fat-suppressed T2-weighted and T1-weighted imaging. Magn Reson Med 77:1049-1057, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
Système de Recherche d'Images et de Navigation Visuelle Basé sur une Approche locale (2003)

International audience
Design and Testing of a Modular SiC based Power Block (2016)

The paper describes a modular, power electronics building block based on GE's industry-leading SiC MOSFET technology and vertically integrated design approach to achieve maximum performance in power applications ranging from solar, wind and HEV/EV to Industrial and Traction drive applications. This plug-and-play unit enables customers to launch high-performance products more quickly, and at lower cost versus conventional design approaches. The Power block is comprised of low-inductance SiC modules with high performance gate drives, optimized bus bar with DC capacitors, air or liquid-cooled thermal management, sensors feeding low-level controls and protection, a standardized control interface, and connectivity to GE's Predix engine for data analytics. It uses a simple, twolevel topology capable of switching up to 40kHz with a DC link voltage up to 1500V.
Fullerenes in the Cretaceous-Tertiary Boundary Layer (1994)

High-pressure liquid chromatography with ultraviolet-visible spectral analysis of toluene extracts of samples from two Cretaceous-Tertiary (K-T) boundary sites in New Zealand has revealed the presence of C(60) at concentrations of 0.1 to 0.2 parts per million of the associated soot. This technique verified also that fullerenes are produced in similar amounts in the soots of common flames under ambient atmospheric conditions. Therefore, the C(60) in the K-T boundary layer may have originated in the extensive wildfires that were associated with the cataclysmic impact event that terminated the Mezozoic era about 65 million years ago.
Dynamic Loss Minimization Using Improved Deadbeat-Direct Torque and Flux Control for Interior Permanent-Magnet Synchronous Machines (2013)

Direct torque control (DTC) has become a widely acceptable alternative to field-oriented control. Deadbeat-direct torque and flux control (DB-DTFC) is a significant improvement over the classical DTC methods and provides opportunities for fast torque control and dynamic loss minimization control. The existing high-switching DB-DTFC solution is based on approximate discrete-time models. This paper presents a more accurate model so that, even at low switching frequencies, proper DB-DTFC control can be achieved. The instantaneous dynamic loss model, which is a function of volt-second selection in each switching period, containing nonlinear effects such as minor hysteresis loops is theoretically derived and evaluated by both FEA simulation and experiments. With this calibrated dynamic loss model, deadbeat dynamic loss minimization control is implemented and integrated in DB-DTFC. Finally, the dynamic loss minimization control is evaluated experimentally and compared with the existing steady-state loss minimization control.
Corticospinal Tract Abnormalities Are Associated with Weakness in Multiple Sclerosis (2007)

MR imaging abnormalities specific to the motor tract are associated with clinical dysfunction related to that tract. The relevant abnormalities are found in the brain stem, distant from the periventricular inflammatory lesions that are common in MS. This suggests that neurodegeneration, rather than primary inflammation, at least partially explains the findings.
Large-area, semiconductor transverse Bragg resonance (TBR) lasers for efficient, high power operation (2005)

By incorporating a transverse Bragg grating into a large-area laser, the optical modes of the laser can be designed to improve the efficiency compared to traditional index-guided lasers. The resulting transverse Bragg resonance (TBR) waveguide can be designed to have a single lateral mode that is distributed throughout the entire width of the laser for efficient, stable, single lateral mode operation even at high powers. In addition, by designing the dispersion of the TBR modes, we can increase the modal gain at the desired lasing frequencies for further efficiency improvements. We have fabricated electrically pumped, semiconductor TBR lasers in the InP/InGaAsP material system to demonstrate the efficiency gains possible by the incorporation of such a transverse Bragg grating.
An Amino Acid Triplet in the NH2 Terminus of Rat ROMK1 Determines Interaction with SUR2B (2001)

ATP-regulated (K(ATP)) channels are formed by an inward rectifier pore-forming subunit (Kir) and a sulfonylurea (glibenclamide)-binding protein, a member of the ATP binding cassette family (sulfonylurea receptor (SUR) or cystic fibrosis transmembrane conductance regulator). The latter is required to confer glibenclamide sensitivity to K(ATP) channels. In the mammalian kidney ROMK1-3 are components of K(ATP) channels that mediate K(+) secretion into urine. ROMK1 and ROMK3 splice variants share the core polypeptide of ROMK2 but also have distinct NH(2)-terminal extensions of 19 and 26 amino acids, respectively. The SUR2B is also expressed in rat kidney tubules and may combine with Kir.1 to form renal K(ATP) channels. Our previous studies showed that co-expression of ROMK2, but not ROMK1 or ROMK3, with rat SUR2B in oocytes generated glibenclamide-sensitive K(+) currents. These data suggest that the NH(2)-terminal extensions in both ROMK1 and ROMK3 block ROMK-SUR2B interaction. Seven amino acids in the NH(2)-terminal extensions of ROMK1 and ROMK3 are identical (amino acids 13-19 in ROMK1 and 20-26 in ROMK3) and may determine ROMK-SUR2B interaction. We constructed a series of hemagglutinin-tagged ROMK1 NH(2)-terminal deletion and substitution mutants and examined glibenclamide-sensitive K(+) currents in oocytes when co-expressed with SUR2B. These studies identified an amino acid triplet "IRA" within the conserved segment in the NH(2) terminus of ROMK1 and ROMK3 that blocks the ability of SUR2B to confer glibenclamide sensitivity to the expressed K(+) currents. The position of this triplet in the ROMK1 NH(2)-terminal extension is also important for the ROMK-SUR2B interactions. In vitro co-translation and immunoprecipitation studies with hemagglutinin-tagged ROMK mutants and SUR2B indicted that direct interaction between these two proteins is required for glibenclamide sensitivity of induced K(+) currents in oocytes. These results suggest that the IRA triplet in the NH(2)-terminal extensions of both ROMK1 and ROMK3 plays a key role in subunit assembly of the renal secretary K(ATP) channel.
Optical properties of hydrogels filled with dispersed nanoparticles (2017)

This paper reports on a study of novel heterohydrogel materials with regular inclusions of the dispersed phase such as polystyrene latex nanoparticles. Synthesized 3D hydrogel matrices contain a balanced number of cross-links and a defined amount of polystyrene nanoparticles with 50 or 85 nm in radius. This study has shown that the obtained hydrogel matrices are capable of changing the swelling degree and their optical properties depending on the size and concentration of the dispersed nanoparticles. The results of the performed studies revealed that the synthesized 3D hydrogels are sensitive for even small changes of glucose concentration and therefore are very promising materials for biosensors.
Predicted gains from recurrent selection in the BS11 maize population (1999)

Random genetic drift and inbreeding depression resulting from the use of small effective population size limit the gain of recurrent selection programs. The objectives of our study were to predict the gains of S2, S1, full-sib, and modified-ear-to-row recurrent selection methods in maize (Zea mays L.) with varying effective population sizes of 5, 10, 20, and 30 and to compare these predicted gains with the realized gains obtained in a related study. Using the variance estimates of the BS11C0 population, predicted gain cycle-1 was computed based on single trait selection and index selection. Predicted gain cycle-1 for S1-progeny selection method in the BS11 maize population was also computed by multiplying the heritabilities and the selection differentials obtained from the original selection. Results showed that the trend was similar for single trait selection and index selection. Relatively higher predicted values were observed for the inbred progeny recurrent selection methods in all traits. Predicted gain cycle-1 for a trait in a recurrent selection method increased with increasing effective population size but differences among the predicted values were agronomically insignificant. While the predictions based on single trait and index selection showed increasing grain yield with increasing effective population size, results from the selection trials of the S1 programs showed otherwise. The comparison between our predictions and the realized gains obtained in a related study indicated that intermating more than 10 individuals would not result in a significant response over a few generations of selection. There is no distinct advantage of using an effective population size of greater than 10 to realize gain in a short-term maize recurrent selection program.
Quantum advantage for differential equation analysis (2020)

Quantum algorithms for both differential equation solving and for machine learning potentially offer an exponential speedup over all known classical algorithms. However, there also exist obstacles to obtaining this potential speedup in useful problem instances. The essential obstacle for quantum differential equation solving is that outputting useful information may require difficult post-processing, and the essential obstacle for quantum machine learning is that inputting the training set is a difficult task just by itself. In this paper, we demonstrate, when combined, these difficulties solve one another. We show how the output of quantum differential equation solving can serve as the input for quantum machine learning, allowing dynamical analysis in terms of principal components, power spectra, and wavelet decompositions. To illustrate this, we consider continuous time Markov processes on epidemiological and social networks. These quantum algorithms provide an exponential advantage over existing classical Monte Carlo methods.
More damaging than we think: Systemic effects of intestinal inflammation (2009)

Comment on: Westbrook AM, et al. Intestinal mucosal inflammation leads to systemic genotoxicity in mice. Cancer Res 2009; 69:4827-34.
Map matching (2013)

Hidden Markov Models (HMMs) based map matching - that matches a sequence of location samples to a road network - has received a lot of traction in recent years. In this paper we revisit the basic assumption underlying HMM-based map matching algorithms, namely, the hypothesis that the true mobility is Markovian. We use the Chapman-Kolmogorov test and argue that mobility is non-Markovian (especially when the moving object has an intent to reach a specific destination) using thousands of real taxicab mobility datasets spanning several weeks. Based on these observations we present an alternate approach to the map matching problem that relies exclusively on shortest path computations, which are at most linear in the number of road segments, and thus avoids expensive complexity of HMM-based map matching algorithms (e.g., using a Viterbi decoder). We present extensive experimental results to show that our approach vastly outperforms HMM-based approaches in terms of both computational complexity and accuracy.
Comparison in dairy cattle of mucosal toxicity of calcium formate and calcium chloride in oil (2000)

Calcium formate, in the high concentrations required for therapy of hypocalcaemia may not be a safe treatment.
Supplementary Data from Adenovirus Targeting to Prostate-Specific Membrane Antigen through Virus-Displayed, Semirandom Peptide Library Screening (2023)

Supplementary Data from Adenovirus Targeting to Prostate-Specific Membrane Antigen through Virus-Displayed, Semirandom Peptide Library Screening
Toward Biochemical Conversion of Lignocellulose On-Farm: Pretreatment and Hydrolysis of Corn Stover in Situ (2017)

Abstract. High-solids lignocellulosic pretreatment using NaOH followed by high-solids enzymatic hydrolysis was evaluated for an on-farm biochemical conversion process. Increasing the solids loadings for these processes has the potential for increasing glucose concentrations and downstream ethanol production; however, sequential processing at high-solids loading similar to an on-farm cellulose conversion system has not been studied. This research quantified the effects of high-solids pretreatment with NaOH and subsequent high-solids enzymatic hydrolysis on cellulose conversion. As expected, conversion efficiency was reduced; however, the highest glucose concentration (40.2 g L -1 ), and therefore the highest potential ethanol concentration, resulted from the high-solids combined pretreatment and hydrolysis. Increasing the enzyme dosage improved cellulose conversion from 9.6% to 36.8% when high-solids loadings were used in both unit operations; however, increasing NaOH loading and pretreatment time did not increase the conversion efficiency. The enzyme-to-substrate ratio had a larger impact on cellulose conversion than the NaOH pretreatment conditions studied, resulting in recommendations for an on-farm bioconversion system. Keywords: Corn stover, Enzymatic hydrolysis, Enzyme loading, High solids, Low solids, Sodium hydroxide.
POLYAMIDE SYNTHESIS BY USE OF TRIPHENYL PHOSPHITE AND QUATERNARY AMMONIUM SALTS (1981)

Quaternary ammonium and pyridinium salts were found to facilitate the reaction of carboxylic acids and amines promoted by triphenyl phosphite, and the reaction was successfully applied to the direct polycondensation reaction of dicarboxylic acids and diamines. Among the salts tested, tetraethylammonium chloride was most favorable. The reaction was extended to the direct polycondensation of amino acids in the presence of polyvinylpyrrolidone as a matrix: poly (β-alanine) with high molecular weight was obtained in high yields, but polymers from α-amino acids could not be isolated due to the difficulty in separating the polymers from the polymer matrix.
WCDMA KPI framework definition methods and applications (2010)

With the development of the commercial applications of WCDMA in the whole world, the comprehensive and scientific measurement and assessment of network performance for WCDMA have become one of the urgent requirements for operators. KPI is always a significant assessment standard for network performance from the 2nd wireless communication. As the KPI/KQI assessment architecture is proposed by TMF and the End-to-End QoS/QoE has become one of the research focuses, KPI is therefore rapidly becoming a indispensable factor in the assessment architecture of WCDMA. Due to the lack of definition framework and methods for KPI, it is difficult for the existing network performance KPI to cover all importance aspects of network and to make fair evaluation of network performance. In response to these needs, this paper proposes a definition methodology composed of the definition criteria, the assessment framework, and the weight division principles for WCDMA KPI. Besides, it also illustrates the measurement and assessment processes of network performance KPI of WCDMA by the practical application experience of Chinese operators.
Phosphorylated tau interactome in the human Alzheimer’s disease brain (2020)

Abstract Background Accumulation of phosphorylated tau (pTau) is a key pathological feature of Alzheimer’s disease (AD). pTau accumulation causes synaptic impairment, neuronal dysfunction and formation of neurofibrillary tangles (NFTs). The pathological actions of pTau are mediated by surrounding neuronal proteins, however our knowledge of the specific proteins that pTau interacts with in AD is surprisingly limited. Therefore, we used two complementary proteomics approaches to map the pTau interactome for the first time. Method We performed quantitative proteomics on NFTs microdissected from patients with advanced AD. Second, we used affinity purification‐mass spectrometry (AP‐MS) to pinpoint which of the proteins identified directly interacted with pTau. Specific proteins of interest were validated using targeted co‐immunoprecipitation (co‐IP) and immunohistochemistry (IHC). Result 542 proteins were identified in NFTs including the detection of many proteins known to be present in NFTs (e.g. MAPT, UBB and APOE). AP‐MS confirmed that 75 proteins present in NFTs directly interacted with pTau. 54 of these proteins have been previously associated with tau, therefore validating our proteomic approach. More importantly, 15 of these proteins were previously known to be associated with AD, but not directly linked to tau (e.g. VAMP2, HNRNPA1). Network analysis showed that the pTau interactome was enriched in proteins involved in the protein ubiquitination pathway and phagosome maturation, and we were able to pinpoint specific proteins that pTau interacts with in these pathways. Importantly, we also identified six novel proteins, not previously known to be associated with pTau or AD. Among these, Secernin‐1 (SCRN1) was selected for validation. Co‐IP of SCRN1 confirmed its interaction with pTau in AD brains, and IHC showed that SCRN1 was uniquely associated with pTau pathology in AD and not in other neurodegenerative diseases such as Pick’s disease, progressive supranuclear palsy, and corticobasal degeneration. Conclusion Combined, our results provide a roadmap for future studies examining the pathological effects of pTau and for identifying possible new drug targets and biomarkers such as SCRN1 for AD.