gebhart/patrepeval huggingface dataset:
Inhibitors of Microglial Neurotoxicity: Focus on Natural Products (2011)

Microglial cells play a dual role in the central nervous system as they have both neurotoxic and neuroprotective effects. Uncontrolled and excessive activation of microglia often contributes to inflammation-mediated neurodegeneration. Recently, much attention has been paid to therapeutic strategies aimed at inhibiting neurotoxic microglial activation. Pharmacological inhibitors of microglial activation are emerging as a result of such endeavors. In this review, natural products-based inhibitors of microglial activation will be reviewed. Potential neuroprotective activity of these compounds will also be discussed. Future works should focus on the discovery of novel drug targets that specifically mediate microglial neurotoxicity rather than neuroprotection. Development of new drugs based on these targets may require a better understanding of microglial biology and neuroinflammation at the molecular, cellular, and systems levels.
Probing the electric field alignment of a thermotropic liquid crystalline polymer by synchrotron radiation (1994)

Abstract The orientation of a cyclic side-chain thermotropic liquid crystalline material in an AC field was monitored in real-time using synchrotron radiation. Monitoring the realignment processes in the millisecond-to-minute time-scale was made possible by the high X-ray flux. Orientation parameters and response times were calculated as a function of temperature and frequency. Response times decreased exponentially with temperature due to a decrease in the viscosity. Very little dependence of the response time on frequency was observed, except at low temperatures, where a switch from homeotropic to planar alignment of the molecules was detected. This reorientation of the director was studied in real-time and the resulting complex diffraction patterns were due to equal but opposite director rotations from an alignment parallel to the applied electric field to an alignment perpendicular to the applied electric field. The orientation parameters were highest in the central portion of the mesophase temperature range. At temperatures near clearing, the net degree of orientation diminished. Cooling through the mesophase with an applied electric field resulted in much larger orientation parameters than could be obtained by aligning at a fixed temperature in the mesophase.
Comparison of two inhouse formulations of technetium Tc 99m albumin (2002)

Journal Article Comparison of two inhouse formulations of technetium Tc 99m albumin Get access Joseph C. Hung, Ph.D., BCNP, FASHP, Joseph C. Hung, Ph.D., BCNP, FASHP Director Nuclear Pharmacy Laboratories and PET Radiochemistry Facility Address correspondence to Dr. Hung at Nuclear Medicine, Department of Radiology, Mayo Clinic, 200 First Street, S.W., Rochester, MN 55905-0001 (jhung@mayo.edu). Search for other works by this author on: Oxford Academic Google Scholar Kyra A. Toulouse, B.S., Kyra A. Toulouse, B.S. Nuclear Pharmacy Laboratories and PET Radiochemistry Facility, Nuclear Medicine, Department of Radiology, MC. Search for other works by this author on: Oxford Academic Google Scholar Barton C. Iverson, B.S., Barton C. Iverson, B.S. Nuclear Pharmacy Laboratories and PET Radiochemistry Facility, Nuclear Medicine, Department of Radiology, MC. Search for other works by this author on: Oxford Academic Google Scholar Douglas W. Mahoney, B.S. Douglas W. Mahoney, B.S. Statistician Section of Biostatistics, Department of Health Sciences Research, MC. Search for other works by this author on: Oxford Academic Google Scholar American Journal of Health-System Pharmacy, Volume 59, Issue 10, 15 May 2002, Pages 964–967, https://doi.org/10.1093/ajhp/59.10.964 Published: 15 May 2002
Special Issue on Data-Driven Personality Modeling for Intelligent Human-Computer Interaction (2020)

Elsevier’s Scopus, the largest abstract and citation database of peer-reviewed literature. Search and access research from the science, technology, medicine, social sciences and arts and humanities fields.
Notice of Removal: 3D ultrafast imaging of the heart: Application to the mapping of electromechanical activation (2017)

Removed.
<title>Framework for measurement of the intensity of motion activity of video segments</title> (2002)

We present a psychophysical and analytical framework for the comparison of the performance of different analytical measures of motion activity in video segments with respect to a subjective ground truth. We first construct a test-set of video segments and conduct a psychophysical experiment to obtain a ground truth for the motion activity. Then we present several low-complexity motion activity descriptors computed from compressed domain block motion vectors. In the first analysis, we quantize the descriptors and show that they perform well against the ground truth. We also show that the MPEG-7 motion activity descriptor is among the best. In the second analysis, we find the pairs of video segments for which the human subjects unanimously rate one as higher activity than the other. Then we examine the specific cases where each descriptor fail to give the correct ordering. We show that the distance from camera, and strong camera motion are main cases where motion vector based descriptors tend to overestimate or underestimate the intensity of motion activity. We finally discuss the experimental methodology and analysis methods we used and possible alternatives. We review the applications of motion activity and how the results presented here relate to those applications.
Supplementary Data from AZD4625 is a Potent and Selective Inhibitor of KRAS<sup>G12C</sup> (2023)

Supplementary Data from AZD4625 is a Potent and Selective Inhibitor of KRAS&lt;sup&gt;G12C&lt;/sup&gt;
Licht für Medizin und Diagnostik (2014)

Abstract Tumortherapie, bildgebende Diagnostik, Fluoreszenzmikroskopie und schaltbare Materialien nutzen und profitieren von photochemischen und photophysikalischen Methoden.
Operation Experience of New Energy Boiler (2011)

王子板紙株式会社日光工場は，原料を古段，雑誌，新聞，上白古紙などを使用し，紙管原紙，色ボール，外装用ライナー生産を行っています。製紙業は，エネルギー多消費型産業であり，世界的に環境保全への要求が高まる中，当工場においても重油からバイオマス・新エネルギーへの燃料転換を図りました。本ボイラは，木質，タイヤ，RPFの他に石炭など多様な燃料を使用しており，これらの燃料の特異性に起因した課題に対してボイラ構造，燃料搬送・供給設備，灰処理設備等様々な対策を施している点に特徴があります。ボイラ構造では，（1）管群部のダスト付着増加に対してはガス輻射室を設置。（2）燃焼室水冷壁の保護対策としては，プロテクタ及び溶射を施し，水管の磨耗を防いでいます。（3）塩素腐食対策としては，スチームエアーヒーター増強しています（ガスエアーヒーター以降）。本報では，水管の磨耗対策，腐食対策による操業トラブルを未然に防止する内容について報告しています。トラブルについては，操業で経験したクリンカについて，経験を生かした対策と今後の対応について報告しています。
Early prediction of median survival among a large AIDS surveillance cohort (2007)

The results of this study suggest that early and accurate prediction of median survival time after AIDS diagnosis may be possible using early quantiles of the survival distribution. The methodology did not seem to work well during a period of significant change in survival as observed with highly active antiretroviral treatment, but results suggest that it may work well in a time of more gradual improvement in survival.
A Wireless Power Transfer System Powering Multiple Gate Drivers in a Modular Multilevel Converter (2019)

In this paper, a novel wireless power transfer system (WPT) is designed for powering the multiple gate drivers in a modular multilevel converter. Considering that the gate drivers are usually distributed over a long distance, the repeater units are designed, which are placed coaxially along the power transfer route. Then the magnetic field can be enhanced by these repeater units and high system efficiency is ensured even with long power transfer distance. Each repeater unit corresponds to a load and consists of two repeater coils that are both bipolar. Moreover, the two bipolar coils in the same repeater unit are placed perpendicularly to remove the magnetic coupling between them. A suitable compensation topology is designed for the proposed WPT system, so that the constant voltage (CV) characteristic can be achieved for each load when neglecting the coil's parasitic resistance. Thus, the load power can be regulated independently without affecting each other, which greatly simplifies the power control design. Experimental results are provided to validate the proposed WPT system.
Infrared Reflectance Spectroscopic Evaluation of Inkjet Printed Standards of Cyclotrimethylenetrinitramine (RDX) on Aluminum Substrates (2018)

The Department of Defense (DOD) and first responder communities are evaluating and developing optical systems for the detection and identification of explosives and components used for assembling homemade explosives (HMEs). Emerging detection technologies must be evaluated with authentic hazard material concentrations to ensure their accurate and reliable use in the field. In this work, infrared (IR) reflectance spectra over the spectral rage of 1000-1700 cm<sup>-1</sup> were collected for different concentrations of inkjet-printed RDX (cyclotrimethylenetrinitramine) samples deposited onto aluminum substrates. A plot of the integrated area of both the symmetric and asymmetric NO<sub>2</sub> vibrational bands for RDX on aluminum exhibited good linearity over the concentration range 20-500 µg/cm<sup>2</sup>. Detection limits for RDX on an aluminum surface were calculated to be 10.7 µg/cm<sup>2</sup> for the symmetric NO<sub>2</sub> vibrational band and 1.4 µg/cm<sup>2</sup> for the asymmetric NO<sub>2</sub> vibrational band. Evaluation of the NO<sub>2</sub> vibrational band areas at different locations of the RDX array demonstrated that the samples exhibited good homogeneity across the surface. The concentration of an unknown sample of RDX on aluminum was determined using the fitted equations; results showed good agreement between the calculated and actual RDX surface concentration. The lot-to-lot variation of RDX on the aluminum surface was compared using the long wavelength infrared (LWIR) spectral band areas for two different lots of standards printed at the same RDX surface concentration. Results showed excellent lot-to-lot agreement indicating good reproducibility of the standards for RDX.
OPTOMAP WIDEFIELD IMAGING OF THE ARGUS II RETINAL PROSTHESIS IN PATIENTS WITH RETINITIS PIGMENTOSA (2015)

Optomap fundus autofluorescence widefield images are useful in determining the configuration of the Argus II cable and the position of the electrode array on the retina and therefore are a useful component of the postoperative surveillance of patients implanted with the device. Using autofluorescence avoids the generation of a light reflection artifact often seen with Optos color imaging.
The conversion of levulinic acid into γ-valerolactone using Cu–ZrO2 catalysts (2016)

A series of Cu–ZrO<sub>2</sub> catalysts prepared by a co-precipitation method were studied for the hydrogenation of levulinic acid to give γ-valerolactone (GVL).
Effect of EAM on Quality Factor and Noise in MEMS Vibratory Gyroscopes (2021)

This paper reports a study on contribution of electromechanical amplitude modulation (EAM) on performance of MEMS Coriolis vibratory gyroscopes (CVGs). We theoretically predicted and experimentally demonstrated the impact of EAM on both quality factor and output noise in MEMS CVGs operating in the open-loop rate mode. We demonstrated the effect on a dynamically amplified dual-mass gyroscope (DAG) improving the gyroscope performance from 0.04 deg/rt-hr in Angular Random Walk (ARW) and 0.52 deg/hr in bias instability to 0.0065 deg/rt-hr in ARW and 0.08 deg/hr in bias instability by changed the EAM setting from 3.5 to 1.2 V in amplitude and from 75 to 225 kHz in frequency. The optimized EAM parameters were derived by the noise prediction model presented in the paper.
Limits of Incremental Conductance for determining the Maximum Power Point under rapidly changing irradiance and an alternative technique based on fast scanning (2014)

In Photovoltaic (PV) energy systems, Maximum Power Point Tracking (MPPT) is essential in order to efficiently use the solar energy converted. There are many MPPT algorithms. Incremental Conductance (IncCond) is a popular algorithm which is widely used for rapidly changing atmospheric conditions. It is shown that it has no significant increase in convergence speed compared with the most popular empirically based Perturb and Observe (P&O) methods. In this paper, an alternative is proposed to track the MPP under rapidly changing atmospheric and partial shading conditions. In response to a sudden change in radiation from 100% to 30%, this method can converge to the MPP in 20ms. This is the fastest convergence time reported to date, which also has the capability of finding the global peak under partial shading conditions. The ultimate limit of how fast any MPPT algorithm can converge is also discussed.
Total Internal Reflection in Gain Media (2015)

We resolve the controversy around total internal reflection from gain media, propose new effects of (extremely) amplified reflection from a single interface, and snow sensitivity to subwavelengtn features.
MECHANISMS UNDERLYING PHYSICAL FRAILTY IN HUMANS (2018)

Physical frailty has a complex and heterogenous biological basis that likely includes genetic influences, age-related biological changes to metabolic processes and stress response systems, and mitochondrial decline. Although it is at present not possible to assign causality to specific biological processes, progress has been made in understanding the contributions of a variety of biological processes that influence frailty. In this symposium, we will provide new information on the role of genetic variants related to iron metabolism in the role of muscle weakness in older adults, on the potential role of mitochondrial DNA in driving frailty and inflammation, and the role of altered metabolic processes as measured by metabolomic variables. Each of these biological domains provide measureable variables that can potentially be used for diagnostic or therapeutic purposes. At the end of this symposium, the audience should be able to better understand the processes that potentially drive frailty in older adults, and the possibilities for future diagnostic and treatment modalities for frailty in older adults.
Systematic Evaluation of Microwave-Assisted Magnetic Recording (2018)

A micro-magnetic simulation model to evaluate microwave-assisted magnetic recording (MAMR) has been developed. Optimization of the spin torque oscillator with ac field strength, head geometry, and oscillating frequency is reported. Realistic recording conditions, including media properties and head parameters, are implemented to show the benefits and challenges of MAMR. We found the out-of-plane component of the ac magnetic field causes erasure when medium anisotropy is low for the system during the writing process even while ferromagnetic resonance is helping switching the recording media grains. The signal-to-noise ratio (SNR) of MAMR is calculated using ensemble waveform analysis with a pseudorandom bit sequence which mimics real user data. The SNR is compared under different recording media anisotropy field while maintaining the same linear density.
Three-dimensional feature understanding based on curvature information of FDG-PET (2018)

The cancer diagnosis based on FDG-PET has become popular in recent years, however false positive shadows occur due to the characteristics of the imaging method. Curvature has invariant properties in analyzing direction and position of organ shape. In this research, we focused on curvature information of PET image. We obtained curvature by getting the Hessian matrix in each voxel of the three-dimensional PET image and calculating its eigenvalues. We confirmed that image based on curvature intensity shows emphasis of liner shadow and outline of tissues. In addition, we expressed running direction of tissues by changing each component of curvature vector into color. Analyzing combination of principal curvature showed certain feature of isolated shadows. Moreover, we expressed more detail running direction on isolated shadows. This paper shows the detailed results of applying these methods to rectal cancer.
Supplementary Table 2 from SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance (2023)

&lt;p&gt;Clinical, pathological, and molecular characteristics of colorectal cancer cases according to SMAD4 expression status in validation cohort&lt;/p&gt;
Numerically Stable Coded Matrix Computations via Circulant and Rotation Matrix Embeddings (2021)

Polynomial based methods have recently been used in several works for mitigating the effect of stragglers (slow or failed nodes) in distributed matrix computations. For a system with <inline-formula> <tex-math notation="LaTeX">$n$ </tex-math></inline-formula> worker nodes where <inline-formula> <tex-math notation="LaTeX">$s$ </tex-math></inline-formula> can be stragglers, these approaches allow for an optimal recovery threshold, whereby the intended result can be decoded as long as any <inline-formula> <tex-math notation="LaTeX">$(n-s)$ </tex-math></inline-formula> worker nodes complete their tasks. However, they suffer from serious numerical issues owing to the condition number of the corresponding real Vandermonde-structured recovery matrices; this condition number grows exponentially in <inline-formula> <tex-math notation="LaTeX">$n$ </tex-math></inline-formula>. We present a novel approach that leverages the properties of circulant permutation matrices and rotation matrices for coded matrix computation. In addition to having an optimal recovery threshold, we demonstrate an upper bound on the worst-case condition number of our recovery matrices which grows as <inline-formula> <tex-math notation="LaTeX">$\approx O(n^{s+5.5})$ </tex-math></inline-formula>; in the practical scenario where <inline-formula> <tex-math notation="LaTeX">$s$ </tex-math></inline-formula> is a constant, this grows polynomially in <inline-formula> <tex-math notation="LaTeX">$n$ </tex-math></inline-formula>. Our schemes leverage the well-behaved conditioning of complex Vandermonde matrices with parameters on the complex unit circle, while still working with computation over the reals. Exhaustive experimental results demonstrate that our proposed method has condition numbers that are orders of magnitude lower than prior work.
Probability of return to the origin at short times: A probe of microstructure in porous media (1995)

A classic problem related to diffusion in restricted geometries is examined here within the framework of pulsed-field-gradient magnetic-resonance measurements and numerical simulations. We show that the short-time behavior of the return to the origin probability can be used to determine the surface area to pore volume ratio in a disordered bead pack and that this procedure is relatively insensitive to the influence of surface relaxation.
Recombinant spider silk proteins as example for supramolecular printable hydrogels (2016)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
Tensile properties of segmented block copolymers with monodisperse hard segments (2008)

The tensile properties of segmented block copolymers with mono-disperse hard segments were studied with respect to the hard segment content (16-44 wt.%) and the temperature (20-110 °C). The copolymers were comprised of poly(tetramethylene oxide) segments with the molecular weights of 650-2,900 Da and of mono-disperse bisester-tetra-amide segments (T6A6T) based on adipic acid (A), terephthalic acid (T) and hexamethylene diamine (6). An increasing content of T6A6T gave rise to an increased modulus, yield stress and fracture stress. The modulus could be modeled by a composite model. Moreover, a strain-softening was observed well below the yield stress, due to the shearing of the T6A6T crystallites. At strains >200%, a strain-hardening of the PTMO segments took place and this even for PTMO segments that were amorphous in the isotropic state. The strain hardening increased the tensile properties. An increase in temperature had little effect on the modulus of the copolymers, but was found to lower the yield and fracture stresses. At temperatures above the melting temperature of the oriented PTMO, no strain-hardening took place. The yield stress as a function of temperature could be described by the Eyring relationship, but a modulus-yield stress relationship could not be established.
High-sensitivity C-reactive protein is associated with clonal hematopoiesis of indeterminate potential (2020)

Clonal hematopoiesis of indeterminate potential (CHIP) is predictive of hematological cancers and cardiovascular diseases, but the etiology of CHIP initiation and clonal expansion is unknown. Several lines of evidence suggest that proinflammatory cytokines may favor mutated hematopoietic stem cell expansion. To investigate the potential link between inflammation and CHIP, we performed targeted deep sequencing of 11 genes previously implicated in CHIP in 1887 subjects aged >70 years from the Montreal Heart Institute Biobank, of which 1359 had prior coronary artery disease (CAD), and 528 controls did not. We assessed association of CHIP with log transformed high-sensitivity C-reactive protein (hs-CRP), a validated biomarker of inflammation. CHIP was identified in 427 of the 1887 subjects (22.6%). CHIP mutations were more frequently identified in DNMT3A (11.6%) and TET2 (6.1%), with a higher proportion of TET2 mutations occurring in controls than in patients with CAD (9.0% vs 4.9%, P < .001). CHIP carriers had 21% higher hs-CRP levels compared with their noncarrier counterparts (eβ = 1.21, 95% confidence interval [CI]: 1.08 to 1.36; P = .001). A similar effect was observed in the subgroup of patients with known CAD (eβ = 1.22, 95% CI: 1.06 to 1.41; P = .005). These findings confirm the association between inflammation and CHIP. This association may open investigational avenues aimed at documenting mechanisms linking inflammation to clonal progression and ultimately supports prevention interventions to attenuate CHIP's impact on cardiovascular disease and cancer.
Oracle TimesTen Scaleout (2018)

Oracle TimesTen Scaleout is a shared-nothing scale-out inmemory database designed for extreme OLTP workloads, such as IoT, real-time fraud detection, telecommunications etc. TimesTen Scaleout features rich SQL including complex queries with joins, aggregations and analytic functions, transparent distributed execution, full ACID multi-statement transactions, global secondary indexes and sequences. The design features built-in high availability using a k-safe data duplication mechanism, and transparent failure handling in order to minimize application down time. All management functions such as installation, configuration, and monitoring are provided via a centralized management repository.