gebhart/patrepeval huggingface dataset:
The prognostic value of tumor markers in patients (pts) with resectable gastric cancer (GC) receiving perioperative therapy in the CRITICS trial. (2021)

4024 Background: Carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 are well-known tumor markers. Most studies on CEA and CA 19-9 in pts with GC were performed in Asia, and/or in the metastatic setting. The aim of this study was to investigate the prognostic value of blood derived laboratory parameters in a cohort of European pts with resectable non-metastatic GC. Methods: In the CRITICS trial, 788 pts with resectable GC underwent perioperative therapy (preoperative chemotherapy plus either postoperative chemotherapy or postoperative chemoradiotherapy). Blood levels of CEA, CA 19-9, alkaline phosphatase (AP), creatinine, neutrophils, hemoglobin (Hb) and lactate dehydrogenase (LDH) were determined prior to treatment. Data for these variables were available for at least 89% of the pts. Factors significant on univariable cox regression analysis were further explored in multivariable analysis. Probabilities to undergo potentially curative surgery was investigated for factors significant on multivariable analysis. The relationship between tumor markers and the presence of circulating tumor DNA (ctDNA) was explored in 50 pts with available ctDNA data. Results: CEA and CA 19-9 were identified as independent prognostic factors for survival (Table). Probabilities to undergo potentially curative surgery were 86%, 77% and 60% for pts with no elevated tumor makers versus those with elevated CEA or elevated CA 19-9 versus those with both tumor markers elevated, respectively (p&lt;0.001). No relationship was found between elevated tumor marker(s) and the presence of ctDNA neither pretreatment nor preoperatively. Conclusions: Pretreatment blood levels of CEA and CA 19-9 were identified as prognostic factors for overall survival in a large cohort of European GC pts with potentially curable disease. These factors may guide treatment choices at an early phase and should be included in future trials to determine their role in clinical decision making.[Table: see text]
Calculation of the dependant demand: the case of batch process industries (2004)

International audience
Molecular dynamics simulation of linear polyethylene blends: Effect of molar mass bimodality on topological characteristics and mechanical behavior (2018)

Blending different molar mass fractions of polyethylene (PE) in order to obtain materials with higher fracture toughness has previously proven beneficial. Our approach has been to use coarse-grained (CG) molecular dynamics (MD) simulations to obtain semicrystalline polyethylene systems on a nanoscale, and then draw them in order to mimic tensile testing. The CG potentials were derived, validated and utilized to simulate melt equilibration, cooling, crystallization and mechanical deformation. Crystallinity, tie chain and entanglement concentrations were continuously monitored. During crystallization, the low molar mass fraction disentangled to a greater degree and ended up with a lower entanglement density than the high molar mass fraction, although the tie chain concentration was higher for the low molar mass fraction. The deformation behavior of semicrystalline PE above its glass transition temperature was then assessed in a uniaxial tensile deformation simulation. The low-strain mechanical properties (i.e. elastic modulus, yield stress and strain) were in accordance with the literature. The high-strain mechanical features and toughness were improved in bimodal systems. The presence of a high molar mass fraction in bimodal systems was shown to affect the crystallinity and tie chain concentration during the strain hardening, leading to tougher model systems. Finally, the bimodal system with equal shares of the molar mass fractions showed the highest toughness and the best ultimate mechanical properties while having a concentration of tie chains and entanglements intermediate between the values for the other systems. This was a clear sign of the non-exclusive role of tie chains and entanglements in the mechanical behavior of bimodal PE and more generally of semicrystalline polymers at high strains.
Microwave response of a metallic superconductor subject to a high-voltage gate electrode (2022)

Processes that lead to the critical-current suppression and change of impedance of a superconductor under the application of an external voltage is an active area of research, especially due to various possible technological applications. In particular, field-effect transistors and radiation detectors have been developed in the recent years, showing the potential for precision and sensitivity exceeding their normal-metal counterparts. In order to describe the phenomenon that leads to the critical-current suppression in metallic superconducting structures, a field-effect hypothesis has been formulated, stating that an electric field can penetrate the metallic superconductor and affect its characteristics. The existence of such an effect would imply the incompleteness of the underlying theory, and hence indicate an important gap in the general comprehension of superconductors. In addition to its theoretical value, a complete understanding of the phenomenon underneath the electric-field response of the superconductor is important in the light of the related technological applications. In this paper, we study the change of the characteristics of a superconductor implementing a coplanar-waveguide resonator as a tank circuit, by relating our measurements to the reactance and resistance of the material. Namely, we track the state of the superconductor at different voltages and resulting leakage currents of a nearby gate electrode which is not galvanically connected to the resonator. By comparing the effects of the leakage current and of a change in the temperature of the system, we conclude that the observed behaviour in the superconductor is mainly caused by the heat that is deposited by the leakage current, and bearing the experimental uncertainties, we are not able to observe the effect of the applied electric field in our sample. In addition, we present a relatively good quantitative agreement between the Mattis-Bardeen theory of a heated superconductor and the experimental observations. Importantly, we do not claim this work to nullify the results of previous works, but rather to provide inspiration for future more thorough experiments and analysis using the methods presented here.
Innenrücktitelbild: Detection of Individual Vapors and Their Mixtures Using a Selectivity‐Tunable Three‐Dimensional Network of Plasmonic Nanoparticles (Angew. Chem. 39/2013) (2013)

Die Detektionsselektivität bleibt die größte Herausforderung bei der Entwicklung von Dampfsensoren, da sie ihre Anwendung in komplexen Systemen beschränkt. In ihrer Zuschrift auf S. 10550 ff. beschreiben R. A. Potyrailo et al. die Detektion von einzelnen Dämpfen und ihren Mischungen unter Verwendung eines einzelnen Sensorfilms, der aus einem dreidimensionalen Netzwerk plasmonischer Nanopartikel besteht. Die einstellbare Selektivität wird mit einem einzigen multivariablen Sensor erzielt.
Nusinersen improves walking distance and reduces fatigue in later‐onset spinal muscular atrophy (2019)

These results support previous studies demonstrating clinically meaningful effects of nusinersen on motor function in children and adolescents with later-onset SMA.
Water Transport Mechanisms in PEMFC Gas Diffusion Layers (2010)

Understanding how water produced in the cathode catalyst layer is removed during proton exchange membrane fuel cell (PEMFC) operation is critical for optimization of materials and model development. The present work combines in situ and ex situ experiments designed to elucidate the dominant water discharge mechanism when considering capillary and vapor transport at normal PEMFC operating conditions. The flux of water vapor driven by the thermal gradient in the cathode diffusion layer can alone be sufficient to remove product water at high current densities even with saturated gas in the delivery channels. The role of an intermediate microporous layer and its impact in vapor vs liquid transport is also considered. We propose that the primary role of the microporous layer is to prevent condensed water from accumulating on and blocking oxygen access to the cathode catalyst layer.
Measurement of Wγ and Zγ production cross sections in pp collisions at s=7 TeV and limits on anomalous triple gauge couplings with the ATLAS detector (2012)

Measurement of W and Z
High-sensitivity, real-time, ratiometric imaging of surface-enhanced Raman scattering nanoparticles with a clinically translatable Raman endoscope device (2013)

Topical application and quantification of targeted, surface-enhanced Raman scattering (SERS) nanoparticles offer a new technique that has the potential for early detection of epithelial cancers of hollow organs. Although less toxic than intravenous delivery, the additional washing required to remove unbound nanoparticles cannot necessarily eliminate nonspecific pooling. Therefore, we developed a real-time, ratiometric imaging technique to determine the relative concentrations of at least two spectrally unique nanoparticle types, where one serves as a nontargeted control. This approach improves the specific detection of bound, targeted nanoparticles by adjusting for working distance and for any nonspecific accumulation following washing. We engineered hardware and software to acquire SERS signals and ratios in real time and display them via a graphical user interface. We report quantitative, ratiometric imaging with nanoparticles at pM and sub-pM concentrations and at varying working distances, up to 50 mm. Additionally, we discuss optimization of a Raman endoscope by evaluating the effects of lens material and fiber coating on background noise, and theoretically modeling and simulating collection efficiency at various working distances. This work will enable the development of a clinically translatable, noncontact Raman endoscope capable of rapidly scanning large, topographically complex tissue surfaces for small and otherwise hard to detect lesions.
USSR: An ultrasound sparse regularization framework (2017)

Ultrafast ultrasound (US) imaging uses unfocused waves to insonify the whole medium of interest at once, allowing pulse-echo US imaging to achieve very high frame rates, at the cost of a lower image quality. In this paper, we present USSR, an UltraSound Sparse Regularization framework which permits high-quality imaging at fast rates and with a very low memory footprint. The framework, based on highly parallelizable, parametric, matrix-free formulations of the measurement model and its adjoint as well as on well-chosen sparsity priors, is implemented on multi-threaded architectures and evaluated on the publicly available PICMUS dataset.
Al-2.136 Top-Surface Imaging (Tsi) (2021)

As increasingly smaller molecular materials and material structures are devised or developed for technological applications, the demands on the processes of lithography now routinely include feature sizes that are of the order of 10 nm. In reaching such a fine level of resolution, the methods of lithography have increased markedly in sophistication and brought into play 2terminology that is unfamiliar, on the one hand, to scientists tasked with the development of new lithographic materials or, on the other, to the engineers who design and operate the complex equipment that is required in modern-day processing. Publications produced by scientists need to be understood by engineers and vice versa, and these commonly arise from collaborative research that draws heavily on the terminology of two or more of the traditional disciplines. It is developments in polymer science and material science that lead progress in areas that cross traditional boundaries, such as microlithography. This document provides the exact definitions of a selection of unfamiliar terms that researchers and practitioners from different disciplines might encounter.
An RF transceiver for digital wireless communication in a 25 GHz Si bipolar technology (2002)

The transceiver chip targets the digital enhanced cordless telecommunication (DECT) standard. Integration level and cost are driven by competition in the wireless market. The transceiver IC is realized on the 25 GHz bipolar process. It is primarily suitable for FSK digital mobile radio portable and base stations. The transceiver IC integrates the complete synthesizer including PLL and fully-integrated VCOs for transmit and receive. The receiver is a single-conversion heterodyne architecture with an image-reject frontend. For demodulation of the FSK modulated signal a coincidence demodulator requiring no external adjustment is used. The IC is packaged in a low-cost TSSOP 38 package. The complete transceiver operates from 3.1 V to 5.1 V and needs no external tuning or trimming.
Multiple user information theory (1980)

A unified framework is given for multiple user information networks. These networks consist of several users communicating to one another in the presence of arbitrary interference and noise. The presence of many senders necessitates a tradeoff in the achievable information transmission rates. The goal is the characterization of the capacity region consisting of all achievable rates. The focus is on broadcast, multiple access, relay, and other channels for which the recent theory is relativdy well developed. A discussion of the Gaussian version of these channels demonstrates the concreteness of the encoding and decoding necessary to achieve optimal information flow. We also offer speculations about the form of a general theory of information flow in networks.
Cycloastragenol Is a Potent Telomerase Activator in Neuronal Cells: Implications for Depression Management (2014)

Cycloastragenol (CAG) is an aglycone of astragaloside IV. It was first identified when screening Astragalus membranaceus extracts for active ingredients with antiaging properties. The present study demonstrates that CAG stimulates telomerase activity and cell proliferation in human neonatal keratinocytes. In particular, CAG promotes scratch wound closure of human neonatal keratinocyte monolayers in vitro. The distinct telomerase-activating property of CAG prompted evaluation of its potential application in the treatment of neurological disorders. Accordingly, CAG induced telomerase activity and cAMP response element binding (CREB) activation in PC12 cells and primary neurons. Blockade of CREB expression in neuronal cells by RNA interference reduced basal telomerase activity, and CAG was no longer efficacious in increasing telomerase activity. CAG treatment not only induced the expression of bcl2, a CREB-regulated gene, but also the expression of telomerase reverse transcriptase in primary cortical neurons. Interestingly, oral administration of CAG for 7 days attenuated depression-like behavior in experimental mice. In conclusion, CAG stimulates telomerase activity in human neonatal keratinocytes and rat neuronal cells, and induces CREB activation followed by tert and bcl2 expression. Furthermore, CAG may have a novel therapeutic role in depression.
Transport and Storage of Hydrogen via Liquid Organic Hydrogen Carrier (LOHC) Systems (2016)

This chapter describes hydrogen storage and transport via LOHC systems. These liquids are characterized by the fact that they can be charged and discharged with considerable amounts of hydrogen in cyclic, catalytic hydrogenation and dehydrogenation processes. The LOHC concept links the technical challenge of storing unsteady energy production from renewables with the vision of a sustainable, hydrogen-based energy system. Suitable LOHC structures have many physicochemical similarities to diesel. Thus, LOHCs can be handled in the existing infrastructure for liquid fuels, a fact that will greatly facilitate their step-wise introduction both for stationary and mobile applications. We consider LOHCs as a very attractive way to provide energy from wind and sun in continuous or demand-oriented manner to all kind of technical applications. Due to their good energy storage densities (up to 2.1 kWh kg−1), low cost, as well as unproblematic toxicology and handling, we anticipate future applications for LOHC systems that would otherwise remain barred for hydrogen technologies based on high pressure or cryogenic hydrogen.
Interaction of reed and resonator by sound generation in a reed organ pipe (2006)

Interaction of reed and resonator in reed organ pipes without and with the resonator has been investigated. The wave form of the sound generated without the resonator attached is a periodic train (with the frequency of reed vibration) of decaying high frequency oscillation. The frequency of this oscillation is independent of the frequency of the reed vibration; it corresponds roughly to the fundamental acoustic resonance of the shallot. Another rather surprising phenomenon was also observed: without the pipe resonator, the reed vibration frequency, and correspondingly the sound frequency is a continuous function of the reed vibrating length, but when the resonator is added “forbidden” frequency domains occur in the vicinity of the eigenfrequencies of the resonator, and the sound frequency jumps abruptly from below to above each resonance frequency of the resonator, when the reed is shortened. This effect can be explained by the coupling between two oscillating systems, the reed and the acoustic resonator. The presented investigations result in a better understanding of the acoustical and mechanical aspects of sound generation in reed pipes, which may allow organ builders and voicers to easier pipe design and more accurate voicing to obtain the desired sound.
Synthesis and Structuring of Ni MoS2 by using an Ionic Liquid (2012)

Abstract To minimize air pollution resulting from exhaust gas emission, a decrease in the concentrations of the sulfur compounds in fuels has become a major issue in the last 10 years. The development of catalysts for the hydrodesulfurization process is a challenge for the oil industry. In the present work, a new and easy way to synthesize Ni‐Mo‐S hydrotreatment catalysts and in particular the effect of ionic liquids on the final structure was studied. It was shown that the addition of the ionic liquid [BMIM][NTf 2 ] to the main reactants [Ni(NO 3 ) 2 · 6H 2 O and (NH 4 ) 2 MoS 4 ] had a great impact on the final product morphology. Indeed, formation of nanoparticles instead of gel was observed, and the amount of ionic liquid introduced helped to control the shape and size of the particles. Moreover, it was also highlighted that the presence of an ionic liquid favored the promotion of MoS 2 with Ni with an optimal Ni/(Ni+Mo) atomic ratio of 0.3, and it also impacted the nanostructure, leading to thinner and shorter MoS 2 slabs, which are two attractive points for catalytic applications.
Characterisation of transcription factors in African swine fever virus (1996)

Conference Article| August 01 1996 Characterisation of transcription factors in African swine fever virus TRACEY BAXTER; TRACEY BAXTER 1Dept. of Biochemistry, University of Liverpool, P.O. Box 147, Liverpool L69 3BX Search for other works by this author on: This Site PubMed Google Scholar MARK. C. WILKINSON; MARK. C. WILKINSON 1Dept. of Biochemistry, University of Liverpool, P.O. Box 147, Liverpool L69 3BX Search for other works by this author on: This Site PubMed Google Scholar PHILIP. C. TURNER; PHILIP. C. TURNER 1Dept. of Biochemistry, University of Liverpool, P.O. Box 147, Liverpool L69 3BX Search for other works by this author on: This Site PubMed Google Scholar LINDA K. DIXON LINDA K. DIXON *Institute for Animal Health, Pirbright Laboratory, Pirbright, Woking, Surrey, GU24 0NF Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1996) 24 (3): 415S. https://doi.org/10.1042/bst024415s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation TRACEY BAXTER, MARK. C. WILKINSON, PHILIP. C. TURNER, LINDA K. DIXON; Characterisation of transcription factors in African swine fever virus. Biochem Soc Trans 1 August 1996; 24 (3): 415S. doi: https://doi.org/10.1042/bst024415s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1996 Biochemical Society1996 Article PDF first page preview Close Modal You do not currently have access to this content.
Osteopontin (OPN) distribution in premalignant and malignant lesions of oral epithelium and expression in cell lines derived from squamous cell carcinoma of the oral cavity (1999)

The objectives of this study were to assess the immunolocalization of human osteopontin (OPN) in oral lesions and to identify human cell lines of oral squamous cell carcinoma (OSCC) origin that express OPN mRNA. OPN was localized using immunohistochemistry in the following oral specimens: normal epithelium (n=6), epithelial hyperplasia (n=4), epithelial dysplasia (n=28), carcinoma in situ (n=11) and squamous cell carcinoma (n=43). Cell lines UMSCC-1, MDA TU 138, MDA 686LN, SCC4, SCC9, SCC25, CAL 27 and MDA 1483 were characterized for OPN mRNA expression using Northern blotting. OPN was not detected in normal oral epithelium. Intracellular and intercellular immunoreactivity was seen in 75% of hyperplasias, 57% of dysplasias, 54% of carcinoma in situ and 67% of squamous cell carcinomas. UMSCC-1 expressed high levels of OPN mRNA. We conclude that OPN protein is detectable in premalignant and malignant lesions arising from oral epithelium. UMSCC-1 may be a useful cell line in which to conduct in vitro studies designed to clarify the role of OPN in OSCC.
Thioredoxin Interacting Protein Is Required for a Chronic Energy-Rich Diet to Promote Intestinal Fructose Absorption (2020)

Increased consumption of fats and added sugars has been associated with an increase in metabolic syndromes. Here we show that mice chronically fed an energy-rich diet (ERD) with high fat and moderate sucrose have enhanced the absorption of a gastrointestinal fructose load, and this required expression of the arrestin domain protein Txnip in the intestinal epithelial cells. ERD feeding induced gene and protein expression of Glut5, and this required the expression of Txnip. Furthermore, Txnip interacted with Rab11a, a small GTPase that facilitates the apical localization of Glut5. We also demonstrate that ERD promoted Txnip/Glut5 complexes in the apical intestinal epithelial cell. Our findings demonstrate that ERD facilitates fructose absorption through a Txnip-dependent mechanism in the intestinal epithelial cell, suggesting that increased fructose absorption could potentially provide a mechanism for worsening of metabolic syndromes in the setting of a chronic ERD.
Tuberculosis Infectiousness and Host Susceptibility (2017)

The transmission of tuberculosis is complex. Necessary factors include a source case with respiratory disease that has developed sufficiently for Mycobacterium tuberculosis to be present in the airways. Viable bacilli must then be released as an aerosol via the respiratory tract of the source case. This is presumed to occur predominantly by coughing but may also happen by other means. Airborne bacilli must be capable of surviving in the external environment before inhalation into a new potential host-steps influenced by ambient conditions and crowding and by M. tuberculosis itself. Innate and adaptive host defenses will then influence whether new infection results; a process that is difficult to study owing to a paucity of animal models and an inability to measure infection directly. This review offers an overview of these steps and highlights the many gaps in knowledge that remain.