gebhart/patrepeval huggingface dataset:
Effects of the Antipsychotic Risperidone on Dopamine Synthesis in Human Brain Measured by Positron Emission Tomography with l-[β-11C]DOPA: A Stabilizing Effect for Dopaminergic Neurotransmission? (2009)

Effects of antipsychotic drugs have widely been considered to be mediated by blockade of postsynaptic dopamine D(2) receptors. Effects of antipsychotics on presynaptic functions of dopaminergic neurotransmission might also be related to therapeutic effects of antipsychotics. To investigate the effects of antipsychotics on presynaptic functions of dopaminergic neurotransmission in relation with occupancy of dopamine D(2) receptors, changes in dopamine synthesis capacity by antipsychotics and occupancy of dopamine D(2) receptors were measured by positron emission tomography (PET) in healthy men. PET studies using [(11)C]raclopride and L-[beta-(11)C]DOPA were performed under resting condition and oral administration of single dose of the antipsychotic drug risperidone on separate days. Although occupancy of dopamine D(2) receptors corresponding dose of risperidone was observed, the changes in dopamine synthesis capacity by the administration of risperidone were not significant, nor was the relation between the occupancy of dopamine D(2) receptors and these changes. A significant negative correlation was observed between the baseline dopamine synthesis capacity and the changes in dopamine synthesis capacity by risperidone, indicating that this antipsychotic can be assumed to stabilize the dopamine synthesis capacity. The therapeutic effects of risperidone in schizophrenia might be related to such stabilizing effects on dopaminergic neurotransmission responsivity.
Brief review of channel capacity (2013)

A summary is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Metabolic oligosaccharide engineering: perspectives, applications, and future directions (2007)

Many adhesion and signaling molecules critical for development, as well as surface markers implicated in diseases ranging from cancer to influenza, contain oligosaccharides that modify their functions. Inside a cell, complex glycosylation pathways assemble these oligosaccharides and attach them to proteins and lipids as they traffic to the cell surface. Until recently, practical technologies to manipulate glycosylation have lagged unlike the molecular biologic and genetic methods available to intervene in nucleic acid and protein biochemistry; now, metabolic oligosaccharide engineering shows promise for manipulating glycosylation. In this methodology, exogenously-supplied non-natural sugars intercept biosynthetic pathways and exploit the remarkable ability of many of the enzymes involved in glycosylation to process metabolites with slightly altered chemical structures. To date, non-natural forms of sialic acid, GalNAc, GlcNAc, and fucose have been incorporated into glycoconjugates that appear on the cell surface; in addition O-GlcNAc protein modification involved in intracellular signaling has been tagged with modified forms of this sugar. Reactive functional groups, including ketones, azides, and thiols, have been incorporated into glycoconjugates and thereby provide chemical 'tags' that can be used for diverse purposes ranging from drug delivery to new modes of carbohydrate-based cell adhesion that can be used to control stem cell destiny. Finally, strategies for further engineering non-natural sugars to improve their pharmacological properties and provide complementary biological activities, such as addition of short chain fatty acids, are discussed in this article.
How do Patients with Heart Failure with Preserved Ejection Fraction Die? (2013)

Understanding how patients with heart failure with preserved ejection fraction (HFPEF) die provides insight into the natural history and pathophysiology of this complex syndrome, thereby allowing better prediction of response to therapy in designing clinical trials. This review summarizes the current state of knowledge surrounding mortality rates, modes of death, and prognostic factors in HFPEF. Despite the lack of uniform reporting, the following conclusions may be drawn from previous studies. The mortality burden of HFPEF is substantial, ranging from 10% to 30% annually, and higher in epidemiological studies than in clinical trials. Mortality rates compared with heart failure with reduced ejection fraction (HFREF) appear to be strongly influenced by the type of study, but are clearly elevated compared with age- and co-morbidity-matched controls without heart failure. The majority of deaths in HFPEF are cardiovascular deaths, comprising 51-60% of deaths in epidemiological studies and ∼70% in clinical trials. Among cardiovascular deaths, sudden death and heart failure death are the leading cardiac modes of death in HFPEF clinical trials. Compared with HFREF, the proportions of cardiovascular deaths, sudden death, and heart failure deaths are lower in HFPEF. Conversely, non-cardiovascular deaths constitute a higher proportion of deaths in HFPEF than in HFREF, particularly in epidemiological studies, where this difference may be related to fewer coronary heart deaths in HFPEF. Key mortality risk factors, including age, gender, body mass index, burden of co-morbidities, and coronary artery disease, offer some explanation for the differences in mortality rates observed across studies.
Interpretable Actions: Controlling Experts with Understandable Commands (2021)

Despite the prevalence of deep neural networks, their single most cited drawback is that, even when successful, their operations are inscrutable. For many applications, the desired outputs are the composition of externally-defined bases. For such decomposable domains, we present a two-stage learning procedure producing combinations of the external bases which are trivially extractable from the network. In the first stage, the set of external bases that will form the solution are modeled as differentiable generator modules, controlled by the same parameters as the external bases. In the second stage, a controller network is created that selects parameters for those generators, either successively or in parallel, to compose the final solution. Through three tasks, we concretely demonstrate how our system yields readily understandable commands. In one, we introduce a new form of artistic style transfer, learning to draw and color with crayons, in which the transformation of a photograph or painting occurs not as a single monolithic computation, but by the composition of thousands of individual, visualizable strokes. The other two tasks, single-pass function approximation with arbitrary bases and shape-based synthesis, show how our approach produces understandable and extractable actions in two disparate domains.
Compliance with recommendations for routine HIV screening during pregnancy in Halifax (2002)

There is inadequate compliance with the recommendation that all women be offered HIV testing during each pregnancy at the IWK Health Centre. Health care professionals involved in obstetrics need to be reminded of the importance of HIV counselling and testing during pregnancy. Further evaluation throughout Canada of the effect of HIV screening recommendations during pregnancy is advisable.
Defense Applications of Nanomaterials (2005)

The U.S. National Nanotechnology Initiative (NNI) is a coordinated multiagency/department program with the NSF leading the fundamental science investment and the other agencies/departments focused on science investment that promises revolutionary new technologies relevant to their missions. The Department of Defense has identified three nanoscience challenges for focused S&T investments - nanoelectronics, magnetics and photonics; nanomaterials; and nanobiodevices. This article will succinctly sketch the reasons for excitement over nanoscience and the DoD program
Technical Note: Plant Survival Assessment on Wetland and Stream Mitigation Sites Using GPS/GIS Geotagging (2010)

Approximately 100,000 ha of compensatory mitigated wetlands within the United States each year require annual environmental assessments. Regulatory agencies evaluate the assessments, which progress for several years following the restoration of wetlands. Core to each annual assessment is the survivorship documentation of the reestablished hydrophytic tree and shrub species. Failure to achieve a preset survival percentage is costly, as it will necessitate a mandatory replanting and an extension of the assessment period. Multiple failures within a region will promote increasing the ratio of mitigated wetland to permitted fill area, as the mandated goal is to maintain a region's wetland base.
Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer (2014)

A variety of human cancers, including nonsmall cell lung (NSCLC), breast, and colon cancers, are driven by the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases. Having shown that bisphosphonates, a class of drugs used widely for the therapy of osteoporosis and metastatic bone disease, reduce cancer cell viability by targeting HER1, we explored their potential utility in the prevention and therapy of HER-driven cancers. We show that bisphosphonates inhibit colony formation by HER1(ΔE746-A750)-driven HCC827 NSCLCs and HER1(wt)-expressing MB231 triple negative breast cancers, but not by HER(low)-SW620 colon cancers. In parallel, oral gavage with bisphosphonates of mice xenografted with HCC827 or MB231 cells led to a significant reduction in tumor volume in both treatment and prevention protocols. This result was not seen with mice harboring HER(low) SW620 xenografts. We next explored whether bisphosphonates can serve as adjunctive therapies to tyrosine kinase inhibitors (TKIs), namely gefitinib and erlotinib, and whether the drugs can target TKI-resistant NSCLCs. In silico docking, together with molecular dynamics and anisotropic network modeling, showed that bisphosphonates bind to TKIs within the HER1 kinase domain. As predicted from this combinatorial binding, bisphosphonates enhanced the effects of TKIs in reducing cell viability and driving tumor regression in mice. Impressively, the drugs also overcame erlotinib resistance acquired through the gatekeeper mutation T790M, thus offering an option for TKI-resistant NSCLCs. We suggest that bisphosphonates can potentially be repurposed for the prevention and adjunctive therapy of HER1-driven cancers.
A 40-Gb/s integrated clock and data recovery circuit in a 50-GHz f/sub T/ silicon bipolar technology (1999)

Clock and data recovery (CDR) circuits are key electronic components in future optical broadband communication systems. In this paper, we present a 40-Gb/s integrated CDR circuit applying a phase-locked loop technique. The IC has been fabricated in a 50-GHz f/sub T/ self-aligned double-polysilicon bipolar technology using only production-like process steps. The achieved data rate is a record value for silicon and comparable with the best results for this type of circuit realized in SiGe and III-V technologies.
Pulmonary Ventilation-Perfusion Relations after Heart Valve Replacement or Repair in Man* (1965)

The anatomical shunt may be larger than 2% in cer- tain diseased states ( An anatomic shunt of 2% of the cardiac output is our estimate of the average ana-
A fully integrated differential 5-6GHz LNA with on-chip balun for WLAN applications (2005)

We present the design of an integrated differential low noise amplifier (LNA) for WLAN applications in the 5-6 GHz range using a SiGe BiCMOS process. The output and input of the amplifier are matched internally to 50 Omega. The amplifier includes an input and output balun. EM-simulation is used to design these baluns. The LNA exhibits 15.7 dB power gain, while the noise figure is lower than 2.23 dB. The PldB is -12.2 dBm and the power consumption from a single 1.8 V is 24.8 mW.
A comparison of preterm and adult airway smooth muscle mechanics (1989)

To determine whether airway smooth muscle undergoes a maturational change regarding force generation, length-tension relationships were determined in isolated trachealis strips from adult and preterm sheep. At the length of maximum force generation, passive active and total tensions of the adult muscle were 2.5 times greater than preterm values (P less than 0.001). KCl stimulation yielded a greater peak tension in the adult strips than in the preterm strips (P less than 0.01). Preterm strips required higher concentrations of KCl to initiate contractions and higher concentrations to reach peak tension. Acetylcholine- (ACh) induced contraction resulted in greater force development at each dose in the adult strips compared with preterm strips (P less than 0.001). The dose of ACh required to reach a half-maximal response was significantly less for the adult strips than for the preterm strips (P less than 0.005). These data demonstrate that both force generation and receptor sensitivity increase with age. This inability of immature smooth muscle to generate as much force as adult smooth muscle may help explain why very preterm neonates requiring intermittent positive-pressure ventilation are at risk for developing structural airway problems.
Monitoring internal power transformer temperature using distributed optical fiber sensors (2020)

Condition monitoring of power transformers is of great importance for the timely detection of incipient faults to avoid potential malfunctioning. Transformer insulating oil contains about 70% of diagnostic information, and a dramatic rise in oil temperature may drastically reduce the lifetime of power transformers, and thus the temperature of the oil is considered the most crucial parameter that has to be monitored continuously in real-time. Compared to traditional temperature measurement methods used in transformer condition monitoring, distributed optical fiber sensors have inherent advantages of immunity to electromagnetic interference and insulation at high-voltage levels, and they offer spatially resolved temperature monitoring with high accuracy and sensitivity. In this study, optical fiber-based distributed temperature measurement of a fully energized 100 kVA distribution transformer is demonstrated by using two different techniques: Optical Frequency Domain Reflectometry (OFDR) and Fiber Bragg Grating (FBG) sensor array. The fiber sensors are robust for a safe long-term installation into oil-filled distribution transformers during manufacturing, and they can withstand heat runs, long-term hot oil immersion, and transformer vibration. The internal transformer temperature is monitored during standard thermal tests prior to installation on the distribution system. The test results show very good agreement between the standard thermocouple and proposed distributed fiber temperature sensors, providing transformer manufacturers with new insights into the distribution of temperatures internal to their commercial products.
Correlation between Crystallinity and Formation of Oxygen Vacancies in IGZO - Comparison between Crystal and Amorphous Using First-Principles Calculations -<br /> (2015)

2015 International Conference on Solid State Devices and Materials,Correlation between Crystallinity and Formation of Oxygen Vacancies in IGZO - Comparison between Crystal and Amorphous Using First-Principles Calculations -<br />
Clustered somatic mutations in and around first exon of non-rearranged c-myc in Burkitt lymphoma with t(8;22) translocation (1987)

We have examined the restriction map of the c-myc gene in 15 BL cell lines carrying the variant t(8;22) translocation in which c-myc is known to remain on chromosome 8. Using 3 restriction enzymes cutting outside the c-myc domain (EcoRI, BamHI, HindIII), we found no evidence for a c-myc/Ig lambda rearrangement in 14 BL cell lines. In the last one, BL 37, the 3' flanking region was rearranged corresponding to the already identified breakpoint located 400 pb downstream from the c-myc gene (9). Using 4 restriction enzymes cutting inside the c-myc gene (PvuII, PstI, SacI, HincII) we looked for discrete abnormalities within the gene limits, and we found in 9 BL cell lines several abolished and created sites, compatible with multiple independent somatic mutations. They are significantly clustered in the 5' non coding region, with a striking prevalence at the end of exon 1. The role of mutations in the non-coding first exon region for the deregulation of c-myc expression is discussed.
Syphilis: Epidemiological Aspects (2012)

Abstract Syphilis continues to represent a significant public health issue. The number of cases globally remains high at over ten million newly infected patients each year, with highest rates seen in countries of low income. The main mode of transmission is by sexual contact, with men who have sex with men, co‐infection with human immunodeficiency virus (HIV) and the sexually promiscuous particularly at risk. Infection rates are also linked with times of war and social upheaval; this is also true of other sexually transmitted diseases. Prevention of new cases is clearly desirable. Most major health organisations (including the CDC and WHO) have elimination plans which rely on education, promotion of safe sexual practices and screening of high‐risk individuals at the core of the strategy. Key Concepts: Clinical differences in the treponematoses have been attributed to adaptation of the organism to climatic factors. An African rather than an American origin is suggested for syphilis. The control of syphilis by public health measures is exemplified by a lower incidence of syphilis in Europe and North America than the rest of the world. An increased incidence in syphilis is found associated with wars and civil disturbance.
Edge-Computing-Assisted Virtual Reality Computation Offloading: An Empirical Study (2022)

Offloading heavy virtual reality (VR) computational operations to a network edge computation entity is receiving increasing attention as a tool to wirelessly and energy efficiently provide low-end client devices with high-quality and immersive interactive VR services anytime and anywhere across the globe. In this work, we aim to provide an understanding of various characteristics of VR computation offloading through comprehensive experiments conducted using a prototype testbed for edge-assisted VR processing and streaming. First, we investigate the benefits of VR offloading in terms of computational load and power consumption reduction for a client device compared to standalone operation. Next, we measure VR traffic patterns, including frame size and data and packet rates with various settings, such as different resolution and encoding options. We also measure several performance metrics associated with the quality of experience, namely, frame rate, packet loss rate, and image quality, with various configuration settings. Then, we present latency measurement studies and investigate per-component latency with various settings. Furthermore, we report the rigorous experiments performed to study the impacts of latency and motion patterns on the black borders formed due to image reprojection and the overfilling technique used to eliminate these black borders.
Chromosomal orientation of the lambda light chain locus: Vλ is proximal to Cλ in 22q11 (1985)

We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the C lambda and some V lambda sequences translocate to the 8q+ chromosome whereas some V lambda sequences remain on the 22q-. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that V lambda is proximal to C lambda.
A highly efficient 1.95-GHz, 18-W asymmetric multilevel outphasing transmitter for wideband applications (2011)

A 1.95-GHz asymmetric multilevel outphasing (AMO) transmitter with class-E GaN power amplifiers (PAs) and discrete supply modulators is presented. AMO transmitters achieve improved efficiency over envelope tracking (ET) transmitters by replacing the continuous supply modulator with a discrete supply modulator implemented with a fast digital switching network. Outphasing modulation is used to provide the required fine output envelope control. A 4-level supply modulator is implemented that allows for fast and efficient discrete envelope modulation with up to 28-V supply voltages using low-voltage gate drivers and time-alignment logic. With two class-E GaN PAs that achieve 62.5% power-added efficiency (PAE) at 40- dBm peak output power, the AMO transmitter delivers 42.6- dBm peak output power at 1.95-GHz. For a 16-QAM signal at 36-dBm output power, the transmitter achieves 44.2/42.8/41.4% average system efficiency and 2.0/2.1/3.1% EVM for 10/20/40-MHz channel bandwidth, respectively.
Performance analysis and optimization of a robust algorithm for voltage transients detection (2004)

In the instruments dedicated to the characterization of transient disturbances affecting the power supply, an event detection block activates the storage and processing functions only when necessary. In a previous contribution, the authors described a simple, robust and fast algorithm, which can easily be loaded on a DSP board to implement the above block. In this paper, the algorithm performance is investigated with special attention to its limitations. Optimization rules are provided and the results of experimental tests are reported and discussed.
Efficient Energy Sensitization of C60 and Application to Organic Photovoltaics (2013)

Fullerenes are currently the most popular electron-acceptor material used in organic photovoltaics (OPVs) due to their superior properties, such as good electron conductivity and efficient charge separation at the donor/acceptor interface. However, low absorptivity in the visible spectral region is a significant drawback of fullerenes. In this study, we have designed a zinc chlorodipyrrin derivative (ZCl) that absorbs strongly in the visible region (450-600 nm) with an optical density 7-fold higher than a C60 film. ZCl efficiently transfers absorbed photoenergy to C60 in mixed films. Application of ZCl as an energy sensitizer in OPV devices leads to an increase in the photocurrent from the acceptor layer, without changing the other device characteristics, i.e., open circuit voltage and fill factor. For example, C60-based OPVs with and without the sensitizer give 4.03 and 3.05 mA/cm(2), respectively, while both have V(OC) = 0.88 V and FF = 0.44. Our ZCl sensitization approach improves the absorbance of the electron-acceptor layer while still utilizing the beneficial characteristics of C60 in OPVs.
Decorin Affects Endothelial Cells by Akt‐Dependent and ‐Independent Pathways (2002)

Decorin, a small multifunctional proteoglycan, has been shown to be causally involved in the formation of capillary-like structures and a decrease in apoptosis. Here we investigated signal transduction pathways mediating effects of decorin on endothelial cells (ECs). Addition of decorin led to a fourfold increase in phosphorylation of Akt/protein kinase B on Thr307 and a l.4-fold increase on Ser473 after 10 min, but this phosphorylation could not be blocked by preincubation with Ly29400 (10 micro M). Six hours after the addition of decorin, the synthesis of p21 and p27, two inhibitors of cyclin-dependent kinases, started and increased up to 18 h, while synthesis of cyclin A peaked at 12 h and decreased after 24 h below base level. Induction of dominan-negative Akt by a replication-deficient adenovirus blocked p21 and cyclin A synthesis, but had no effect on p27. Dominant-negative Akt also blocked the antiapoptotic effect of decorin on ECs, but induction of dominant-positive Akt could not rescue the cells from apoptosis. Thus, the matrix proteoglycan decorin is a signaling molecule in ECs that affects cell survival by Akt-dependent and -independent pathways.