gebhart/patrepeval huggingface dataset:
Cover Picture: SERS Aptatags: New Responsive Metallic Nanostructures for Heterogeneous Protein Detection by Surface Enhanced Raman Spectroscopy (Adv. Funct. Mater. 17/2008) (2008)

On page 2518, Bazan and co-workers describe the design and function of “aptatags” that consist of aptamer-decorated silver nanoparticles brought together by an organic linker. This linkeris strategically located where surface enhancement of Raman signals takes place. The aptamer probes were chosen to selectively bind specific proteins. These structural attributes of aptatags allow the development of a new heterogeneous protein detection method.
Isolation and Chondrogenic Differentiation of Porcine Perichondrial Progenitor Cells for the Purpose of Cartilage Tissue Engineering (2013)

In vivo, cartilage has a limited regenerative capacity. Clinical replacement strategies require a suitable cell source to provide a stable chondrocyte phenotype without hypertrophic cartilage development, while being broadly available, and harboring a high proliferative potential. Thus, the aim of this study was to analyze the proliferation and chondrogenic differentiation capacity of porcine perichondrial progenitor cells (PPC) isolated from auricular (ePPC) and tracheal cartilage (tPPC) as an alternative cell source to mesenchymal stem cells (MSC). The proliferative potential of these cell types was analyzed by means of doubling times. Cell pellets were cultured in chondrogenic differentiation medium for 4 weeks. Potential chondrogenic differentiation was investigated by histology and immunohistology in addition to gene expression analysis of the cartilage markers collagen II, aggrecan, cartilage oligomeric matrix protein (COMP), the precartilage marker collagen I, and the hypertrophic cartilage marker collagen X. PPC showed a proliferative behavior comparable to that of MSC. Chondrogenic stimulation resulted in a higher expression of collagen II, aggrecan, and COMP in ePPC as compared to tPPC and MSC, whereas the expression of collagen I was comparable in all cell types independently of differentiation stimulation. Collagen type X, however, could not be detected. The production of cartilage-like extracellular matrix components in PPC pellets was confirmed by histological and immunohistological stains. Elastin, a component of auricular cartilage, however, was not detected in ePPC-derived pellets. Thus, PPC present a promising cell source for tissue engineering of cartilage. Furthermore, ePPC may be more convenient than tPPC due to their higher chondrogenic potential and better accessibility.
Toward nonlinear endomicroscopy for exploration of the pulmonary airways: preliminary spectroscopic study of human lung tissue using a single-mode fibre (2011)

We are developing a non-linear fibered endomicroscope for imaging the extracellular matrix collagen and elastin fibrillar networks during bronchoscopy. As a proof of concept, laser pulses at the output of a standard 2 meter long single-mode fibre have been obtained with pulse duration of about 50 fs and pulse energy up to 50 uJ, using a specially designed grism line for the dispersion compensation. With these pulses, we performed a spectroscopic characterization of the non-linear endogenous signal, consisting of two-photon fluorescence and second harmonic generation, and originated from human pulmonary tissue of various thickness, both in forward and backward geometry of signal collection, with excitation at 830 nm.
Data Traffic Grooming/Exchange of a Single 10-Gbit/s TDM Tributary Channel between Two Pol-Muxed 80-Gbit/s DPSK Channels (2010)

We report tributary channel data traffic grooming/exchange of pol-muxed DPSK signal based on Kerr-induced nonlinear polarization rotation. 8 tributary channel data grooming between two pol-muxed 80-Gbit/s DPSK channels is demonstrated with a penalty of &lt;4 dB.
Evaluation of proposed staging systems for human papillomavirus‐related oropharyngeal squamous cell carcinoma (2017)

The current analysis provides external validation for both staging systems in an independent and heterogeneously treated patient population. Although the MDACC staging system is an improvement over the AJCC-7ed, the ICON-S stage provides superior stratification of overall and progression-free survival, thereby supporting its use as the updated AJCC staging system for OPC. Cancer 2017;123:1768-1777. © 2017 American Cancer Society.
How to Estimate the Success Rate of Higher Order Side-Channels Attacks (2014)

International audience
Synthesis and Mass Spectral Fragmentation Patterns of Brassinolide Early Biosynthetic Precursors Labeled at C-26 (2013)

New analogues of brassinolide biosynthetic precursors with three deuterium atoms at non-exchangeable positions have been synthesized to be used as standards for quantification of natural brassinosteroids by liquid chromatography-mass spectrometry. [26- 2 H 3 ](22 R,23 R,24 S)-22,23-Dihydroxy-6β-methoxy-24-methyl-3α,5-cyclo-5α-cholestane was used as a starting material for the preparation of campestane derivatives having a 22 R,23 R-diol functionality and either a hydroxy or keto group at C-3 and labeled at C-26. The mass spectrometric behavior of the newly synthesized compounds has been studied.
Classification of continuous order-disorder transitions in adsorbed monolayers. II (1979)

We extend the classification of continuous order-disorder transitions in adsorbed systems to encompass additional situations of physical interest. Among these are transitions on substrate arrays which are not simple Bravais lattices. The honeycomb and kagom\'e lattices are treated in detail. Their transitions belong to the universality class of the Ising, three- or four-state Potts model, and the Heisenberg model with cubic anisotropy. A simple case of the transitions of diatomic molecules is also considered. Those of ${\mathrm{Br}}_{2}$ on graphite are predicted to be first order. Lastly, transitions between ordered states are analyzed and an example of experimental interest is discussed.
Grain Yield and Nitrogen Accumulation in Maize Hybrids Released during 1934 to 2013 in the US Midwest (2017)

Nitrogen (N) application in maize ( Zea mays L.) reached a maximum of 145 kg N ha −1 in the US Midwest in 1975. Grain yield has continued to increase at a rate of 111 kg ha −1 yr −1 , implying an improvement in N efficiency. Our objective was to measure the rate of genetic gain and the traits that contributed to the observed N efficiency for a set of DuPont Pioneer hybrids released between the era decades (ERA) of 1934 to 2013. These hybrids represent the most widely sold hybrids (by volume) in each ERA. A randomized complete block experiment in a split‐plot arrangement was conducted at Sciota, IL, and Marion, IA, during 2013 and 2014, with plant densities of 39,500 and 79,000 plants ha −1 as the whole plot, respectively, and 47 ERA hybrids as the split plot. This experiment was grown in a low‐N (56 kg N ha −1 ) block and in a high‐N (&gt;200 kg N ha −1 ) block at each location. Grain yield increased at an average rate of 109 kg ha −1 yr −1 from 1934 to 2013. Partial factor productivity increased from 13.8 in 1934 to 55 kg grain kg applied N −1 in 2013 under high‐N conditions and 79,000 plants ha −1 . Traits associated with yield improvement without increasing N application were (i) greater synchrony in floral development, (ii) reduced concentration of grain N, (iii) increased specific leaf nitrogen, (iv) increased kernel number per ear (KPE), and (v) increased kernel mass. Breeding efforts that select for increased KPE under increased plant density should increase yield, and this yield increase could partially be supported through greater postanthesis N remobilization from vegetative tissue without requiring greater N application.
Immunogenicity and Safety of an Investigational Combined Haemophilus influenzae Type B-Neisseria meningitidis Serogroups C and Y-Tetanus Toxoid Conjugate Vaccine (2010)

HibMenCY-TT induced noninferior Hib and MenC responses compared with monovalent Hib and MenC conjugates with a comparable safety profile. Bactericidal antibodies against MenC/Y were induced after 2 doses of HibMenCY-TT.
Etching mechanisms of thin SiO2 exposed to Cl2 plasma (2011)

Plasma etching is the most standard patterning technology used in micro- and nano-technologies. Chlorine-based plasmas are often used for silicon etching. However, the behavior of thin silicon oxide exposed to such a plasma is still not fully understood. In this paper, we investigate how a thin silicon oxide layer on silicon behaves when it is exposed to a Cl2 plasma. The authors show that chlorine atoms diffuse and/or Cl+ ions are implanted through the thin (&amp;lt;2.5 nm) oxide, leading to the formation of a SiClx interface layer between the two layers of Si and SiO2. Chlorine accumulates at the interface until the SiO2 is thin enough to release volatile SiClx species and the silicon begins to be etched.
The Structured Menstrual History: Developing a Tool to Facilitate Diagnosis and Aid in Symptom Management (2011)

Abnormal uterine bleeding (AUB) is a prevalent symptom that encompasses abnormalities in menstrual regularity, duration, frequency and/or volume, and it is encountered frequently by both primary care physicians and obstetrician-gynecologists. Research on AUB has used numerous methods to measure bleeding and assess symptoms, but the lack of universally accepted outcome measures hinder the quality of research and the ability of clinical investigators to collaborate in multicenter trials. Similarly, clinical care for women reporting heavy, prolonged, or irregular menstrual bleeding is not optimized because standard ways of evaluating symptoms and change in symptoms over time do not exist. This article describes (1) the current methods of evaluating women with AUB, both in research and clinical care; and (2) offers suggestions for the development of a standardized structured menstrual history for use in both research and clinical care.
Growth of Single Crystal Fiber (2021)

Presented by NETL at 6th Workshop on Specialty Optical Fibers, 11/19
RFLPs of the gene for the human glycine receptor on the X-chromosome (1989)

A 65Cbp EcoRJ fragnent frmn the 5' end of the cDNA clone of the gene for 48Kd polypeptide subunit of the human glycine receptor (unpublished data). This clone was obtained by screening a human cDNA library with a rat glycine receptor probe (1).
Synthesis of Oxy Aminated [60] and [70]Fullerenes with Cumene Hydroperoxide as Oxidant. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Human papillomavirus and head and neck squamous cell carcinoma in a UK population: Is there an association? (2021)

The results we provide suggest that HPV infection is low in HNSCC, in general, and absent in OSCC, specifically, in this UK population during this time period. This implies that HPV infection may not play an important role in HNSCC carcinogenesis compared to other risk factors in UK population. This information can aid in more effective treatment approaches for treating UK cases of HNSCC.
ChemInform Abstract: Arylsulfonyl Hydroxamic Acids: Potent and Selective Matrix Metalloproteinase Inhibitors. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Video 4G and H from Selective Targeting and Potent Control of Tumor Growth Using an EphA2/CD3-Bispecific Single-Chain Antibody Construct (2023)

Supplementary Video 4G and H from Selective Targeting and Potent Control of Tumor Growth Using an EphA2/CD3-Bispecific Single-Chain Antibody Construct
[Enzyme inhibitory activities of two Leguminosae: Phaseolus vulgaris L. pods and Vicia faba L. hulls. Trypsin inhibitory activity]. (1989)

Trypsin inhibitory activities of Phaseolus vulgaris L. pods and Vicia faba L. bean hulls have been studied according to the extraction conditions of the powder: solvent pattern, temperature and pH. The two vegetal powders have a trypsin inhibitory activity quite similar, weak but appreciable. The trypsin inhibitor of Phaseolus vulgaris L. pods is thermosensitive but stable at low pH. Inversely the Vicia faba L. bean hulls one is thermostable but it feels low pH.
Length separation of single-walled carbon nanotubes and its impact on structural and electrical properties of wafer-level fabricated carbon nanotube–field-effect transistors (2016)

For an industrial realization of devices based on single-walled carbon nanotube (SWCNTs) such as field-effect transistors (FETs) it becomes increasingly important to consider technological aspects such as intrinsic device structure, integration process controllability as well as yield. From the perspective of a wafer-level integration technology, the influence of SWCNT length on the performance of short-channel CNT-FETs is demonstrated by means of a statistical and comparative study. Therefore, a methodological development of a length separation process based on size-exclusion chromatography was conducted in order to extract well-separated SWCNT dispersions with narrowed length distribution. It could be shown that short SWCNTs adversely affect integrability and reproducibility, underlined by a 25% decline of the integration yield with respect to long SWCNTs. Furthermore, it turns out that the significant changes in electrical performance are directly linked to a SWCNT chain formation in the transistor channel. In particular, CNT-FETs with long SWCNTs outperform reference and short SWCNTs with respect to hole mobility and subthreshold controllability by up to 300% and up to 140%, respectively. As a whole, this study provides a statistical and comparative analysis towards chain-less CNT-FETs fabricated with a wafer-level technology.
Cloud-Powered Sight for All: Showing the Cloud What You See (2012)

We argue that for computers to do more for us, we need to show the cloud what we see and embrace cloud-powered sight for mobile users. We present sample applications that will be empowered by this vision, discuss why the timing is right to tackle it, and offer our initial thoughts on some of the important research challenges. Our rationale is simple: visual information is the richest form of human sensory input. More often than not, it also requires the highest information transfer rate. The human nervous system is centered on the visual experience. We learn, reason, and act based on what we see. Our interactions and collaborations with fellow humans are often triggered by our visual senses and many of our social experiences are influenced by it. By showing our computer what we see, we can not only create the next generation of personalized service but also overcome some the fundamental limitations of being human.
A Strategy to Control the Reactivation of Frustrated Lewis Pairs from Shelf‐Stable Carbene Borane Complexes (2015)

Abstract N‐Phosphine oxide substituted imidazolylidenes (PoxIms) have been synthesized and fully characterized. These species can undergo significant changes to the spatial environment surrounding their carbene center through rotation of the phosphine oxide moiety. Either classical Lewis adducts (CLAs) or frustrated Lewis pairs (FLPs) are thus formed with B(C 6 F 5 ) 3 depending on the orientation of the phosphine oxide group. A strategy to reactivate FLPs from CLAs by exploiting molecular motions that are responsive to external stimuli has therefore been developed. The reactivation conditions were successfully controlled by tuning the strain in the PoxIm–B(C 6 F 5 ) 3 complexes so that reactivation only occurred above ambient temperature.
The Donnan potential revealed (2022)

Selective transport of solutes across a membrane is critical for many biological, water treatment and energy conversion and storage systems. When a charged membrane is equilibrated with an electrolyte, an unequal distribution of ions arises between phases, generating the so-called Donnan electrical potential at the solution/membrane interface. The Donnan potential results in the partial exclusion of co-ion, providing the basis of permselectivity. Although there are well-established ways to indirectly estimate the Donnan potential, it has been widely reported that it cannot be measured directly. Here we report the first direct measurement of the Donnan potential of an ion exchange membrane equilibrated with salt solutions. Our results highlight the dependence of the Donnan potential on external salt concentration and counter-ion valence, and show a reasonable agreement with current theoretical models of IEMs, which incorporate ion activity coefficients. By directly measuring the Donnan potential, we eliminate ambiguities that arise from limitations inherent in current models.
Highly dispersive photonic crystal fiber for beamforming (2007)

In this paper, a highly dispersive pure silica photonic crystal fiber is designed and fabricated with maximum chromatic dispersion value of about -600 ps/(nm·km) around 1.55 &mu;m wavelength region. This kind of a photonic crystal fiber structure is suitable for high dispersion application in photonic crystal fiber array based phased array antenna systems. A four-element true-time delay module is constructed using the fabricated highly dispersive photonic crystal fibers. The true time delay value of 10.5m PCF is characterized to provide maximum delay of 31.3ps with 32nm optical wavelength tuning range, which is sufficient to scan from -45&deg; to 45&deg; for a 4-element PAA subarray having 1.3cm spacing. A multiple-beam optical beamformer is designed based on the fabricated highly dispersive photonic crystal fibers. The true-time delay beamformer can be programmed to continuously sweep the antenna aperture independently for multiple RF beams. Since the dispersion of the fabricated photonic crystal fibers is as high as -600 ps/nm&bull;km at 1550 nm, compared to telecom SMF-28 that has a dispersion parameter of 18 ps/nm&bull;km, the length of delay line is reduced by a factor of 33.
Capacitive MEMS microphones (2005)

More than two billion microphones are produced annually. The electret microphone, invented by Sessler and West in the early 1960s, makes up the bulk of this production. With the desire for more functionality as well as smaller size, microelectromechanical systems (MEMS) microphones are now being proposed to become the microphone of choice for consumer audio applications. There are two major application areas that are driving the interest in MEMS microphones: hearing aids, where size and integration with digital signal processing are important, and consumer devices, where there is interest in reducing costs by integrating a complete systems solution on an integrated circuit. This paper describes some fundamental MEMS microphone design issues. An all-surface machined MEMS microphone that was built at Bell Labs is also described.
Optimal learning of quantum Hamiltonians from high-temperature Gibbs states (2022)

We study the problem of learning a Hamiltonian H to precision $\varepsilon$, supposing we are given copies of its Gibbs state $\rho =\exp(-\beta H)/\mathrm{Tr}(\exp(-\beta H))$ at a known inverse temperature $\beta$. Anshu, Arunachalam, Kuwahara, and Soleimanifar [AAKS21] recently studied the sample complexity (number of copies of $\rho$ needed) of this problem for geometrically local N-qubit Hamiltonians. In the high-temperature (low $\beta$) regime, their algorithm has sample complexity poly (N, 1/$\beta$, 1/$\varepsilon$) and can be implemented with polynomial, but suboptimal, time complexity. In this paper, we study the same question for a more general class of Hamiltonians. We show how to learn the coefficients of a Hamiltonian to error $\varepsilon$ with sample complexity $S=O(\log N/(\beta\varepsilon)^{2}$) and time complexity linear in the sample size, O(SN). Furthermore, we prove a matching lower bound showing that our algorithm’s sample complexity is optimal, and hence our time complexity is also optimal. In the appendix, we show that virtually the same algorithm can be used to learn H from a real-time evolution unitary $e^{-i t H}$ in a small t regime with similar sample and time complexity.
An aerosol-mediated magnetic colloid: Study of nickel nanoparticles (2005)

A method is presented for the synthesis of high-quality nickel nanoparticles. Laser-driven decomposition of nickel carbonyl vapors is used to produce particles in the form of an aerosol, followed by exposure to a solvent containing an appropriate surfactant to yield a stable dispersion of particles. This method is scalable and yields a substantially monodisperse distribution of particles at a relatively high rate of production. The particles produced by this method are subjected to a detailed characterization using transmission electron microscopy, atomic force microscopy, energy dispersive spectroscopy, and dc magnetization. They have an average diameter of 5 nm, and the observed magnetization curves show no hysteresis above 200 K. The normalized magnetization curves follow a scaling law proportional to the quotient of the applied field over temperature. This data indicates the presence of randomly oriented superparamagnetic particles. The measured magnetization is significantly smaller than that of the bulk, probably due to an effective surface anisotropy and spin canting. The coercivity is the same in either direction of the applied field which indicates that there is negligible exchange coupling between the nickel particles and any possible antiferromagnetic oxide layer on their surfaces.
Use ofLactococcus lactisExpressing Pili from Group BStreptococcusas a Broad‐Coverage Vaccine against Streptococcal Disease (2006)

Recent data indicate that the human pathogen group B Streptococcus (GBS) produces pilus-like structures encoded in genomic islands with similar organization to pathogenicity islands. On the basis of the amino acid sequence of their protein components, 3 different types of pili have been identified in GBS, at least 1 of which is present in all isolates. We recently demonstrated that recombinant pilus proteins protect mice from lethal challenge with GBS and are thus potential vaccine candidates. Here, we show that GBS pilin island 1, transferred into the nonpathogenic microorganism Lactococcus lactis, leads to pilus assembly. We also show that systemically or mucosally delivered Lactococcus expressing pilin island 1 protects mice from challenge with GBS isolates carrying pilus 1. Furthermore, lactococci engineered to express hybrid pili containing GBS pilus 1 and pilus 2 components confer protection against strains expressing either of the 2 pilus types. These data pave the way to the design of pilus-based, multivalent live vaccines against streptococcal pathogens.