gebhart/patrepeval huggingface dataset:
3D Modeling on the Go: Interactive 3D Reconstruction of Large-Scale Scenes on Mobile Devices (2015)

This paper presents a system for 3D reconstruction of large-scale outdoor scenes based on monocular motion stereo. Ours is the first such system to run at interactive frame rates on a mobile device (Google Project Tango Tablet), thus allowing a user to reconstruct scenes "on the go" by simply walking around them. We utilize the device's GPU to compute depth maps using plane sweep stereo. We then fuse the depth maps into a global model of the environment represented as a truncated signed distance function in a spatially hashed voxel grid. We observe that in contrast to reconstructing objects in a small volume of interest, or using the near outlier-free data provided by depth sensors, one can rely less on free-space measurements for suppressing outliers in unbounded large-scale scenes. Consequently, we propose a set of simple filtering operations to remove unreliable depth estimates and experimentally demonstrate the benefit of strongly filtering depth maps. We extensively evaluate the system with real as well as synthetic datasets.
Ultraviolet-Assisted Curing of Polycrystalline Pure-Silica Zeolites:  Hydrophobization, Functionalization, and Cross-Linking of Grains (2007)

We demonstrate the advantageous use of an ultraviolet-assisted curing for the preparation of polycrystalline zeolites. The ultraviolet-assisted curing effectively hydrophobizes the porous structure of a spin-on Silicalite-1 film by means of silanol condensation and grafting of desorbing organic template fragments. Moreover, it enhances the packing of the grains, so the intergrain voids are substantially shrunk and the mechanical properties improved.
Synthesis and Biological Evaluation of New Enantiomers of 5-O-Carboranyl Pyrimidine Nucleosides (1999)

Abstract The synthesis of new enantiomers of 5-o-carboranyl pyrimidine nucleosides is described. Some of these agents should be considered for boron neutron capture therapy.
Establishing the selective phospholipid membrane coordination, permeation and lysis properties for a series of ‘druggable’ supramolecular self-associating antimicrobial amphiphiles (2022)

The rise of antimicrobial resistance remains one of the greatest global health threats facing humanity. Furthermore, the development of novel antibiotics has all but ground to a halt due to a collision of intersectional pressures. Herein we determine the antimicrobial efficacy for 14 structurally related supramolecular self-associating amphiphiles against clinically relevant Gram-positive methicillin resistant <i>Staphylococcus aureus</i> and Gram-negative <i>Escherichia coli</i>. We establish the ability of these agents to selectively target phospholipid membranes of differing compositions, through a combination of computational host:guest complex formation simulations, synthetic vesicle lysis, adhesion and membrane fluidity experiments, alongside our novel <sup>1</sup>H NMR CPMG nanodisc coordination assays, to verify a potential mode of action for this class of compounds and enable the production of evermore effective next-generation antimicrobial agents. Finally, we select a 7-compound subset, showing two lead compounds to exhibit 'druggable' profiles through completion of a variety of <i>in vivo</i> and <i>in vitro</i> DMPK studies.
In-utero imaging of developing mouse embryos using a 34-MHz annular array and chirp-coded excitation. (2009)

High-frequency ultrasound (HFU) is becoming a prevalent modality to image biological tissues with fine resolution. HFU imaging is routinely used for ophthalmologic, dermatological, and small-animal applications. Fine-resolution imaging is obtained at the expense of limited depth-of-field and acoustic penetration depth. In this study, a 34-MHz, five-element annular array was excited using chirp-coded signals and a synthetic-focusing algorithm was used to form images. This imaging approach allowed for the simultaneous increase of depth-of-field and penetration depth. Three-dimensional ultrasound datasets of 12.5-day-old mouse-embryo heads were acquired in utero using chirp and conventional excitations. From the synthetically focused images, brain ventricles and embryonic head were segmented and rendered in three dimensions. Significant artifacts such as segmenting ventricles outside the embryonic head were significantly more pronounced on the conventional-imaging reconstruction than on the chirp-based reconstruction. Furthermore, the total ventricle volume obtained with the chirp (6.3 mm3) was similar to that estimated using a μMRI dataset (i.e., 7.5 mm3). The conventional method greatly over evaluated the ventricle volume (11.4 mm3). The results of this study suggest that HFU chirp-annular-array imaging could become a valuable method for medical imaging applications, such as in utero developmental biology. [Work supported by NIH Grants EB006509 and EB008606.]
Receptors, Circuits, and Behaviors: New Directions in Chemical Senses (2008)

The chemical senses, smell and taste, are the most poorly understood sensory modalities. In recent years, however, the field of chemosensation has benefited from new methods and technical innovations that have accelerated the rate of scientific progress. For example, enormous advances have been made in identifying olfactory and gustatory receptor genes and mapping their expression patterns. Genetic tools now permit us to monitor and control neural activity in vivo with unprecedented precision. New imaging techniques allow us to watch neural activity patterns unfold in real time. Finally, improved hardware and software enable multineuron electrophysiological recordings on an expanded scale. These innovations have enabled some fresh approaches to classic problems in chemosensation.
Practical applications of small induction heater (2016)

Small induction heating technology is recent trend for home appliances and industry applications. This paper covers advanced practical applications of small induction heater, as the example bonding methods in building materials and mechanical parts, food cooking devices and superheated steamer.
Latency Measurement of 100 km Fiber Using Correlation-OTDR (2019)

By means of C-OTDR (Correlation - Optical Time Domain Reflectometry), we measured the latency of 100 km fiber with an accuracy of a few picoseconds. Based on iterating 49 measurements, we calculated a standard deviation of 12 ps between the round-trip latency values. To verify the reflection measurements, we used a single pass setup without reflector, which showed a maximum difference of only 11 ps.
Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation (2017)

Transthyretin (TTR) is a homotetrameric protein. Its dissociation into monomers leads to the formation of fibrils that underlie human amyloidogenic diseases. The binding of small molecules to the thyroxin-binding sites in TTR stabilizes the homotetramer and attenuates TTR amyloidosis. Herein, we report on boronic acid-substituted stilbenes that limit TTR amyloidosis in vitro. Assays of affinity for TTR and inhibition of its tendency to form fibrils were coupled with X-ray crystallographic analysis of nine TTR·ligand complexes. The ensuing structure-function data led to a symmetrical diboronic acid that forms a boronic ester reversibly with serine 117. This diboronic acid inhibits fibril formation by both wild-type TTR and a common disease-related variant, V30M TTR, as effectively as does tafamidis, a small-molecule drug used to treat TTR-related amyloidosis in the clinic. These findings establish a new modality for covalent inhibition of fibril formation and illuminate a path for future optimization.
Optimization methodology for efficient LLC resonant converter with power factor correction circuit (2012)

High efficiency is required in power conversion circuits. A systematic optimization procedure is presented in this paper to optimize LLC series resonant converter efficiency where the effect of LLC input voltage variation cased by power factor correction circuit is considered. A mode solver technique is proposed to handle LLC converter steady-state solutions under different input voltage conditions. Loss models are provided to calculate total component losses using the current and voltage information derived from the mode solver. A prototype 300W 12V output LLC converter is built using the optimization results. Experimental results are presented.
Overexpression of the cytosolic cytokinin oxidase/dehydrogenase (CKX7) from Arabidopsis causes specific changes in root growth and xylem differentiation (2014)

Degradation of the plant hormone cytokinin is catalyzed by cytokinin oxidase/dehydrogenase (CKX) enzymes. The Arabidopsis thaliana genome encodes seven CKX proteins which differ in subcellular localization and substrate specificity. Here we analyze the CKX7 gene, which to the best of our knowledge has not yet been studied. pCKX7:GUS expression was detected in the vasculature, the transmitting tissue and the mature embryo sac. A CKX7-GFP fusion protein localized to the cytosol, which is unique among all CKX family members. 35S:CKX7-expressing plants developed short, early terminating primary roots with smaller apical meristems, contrasting with plants overexpressing other CKX genes. The vascular bundles of 35S:CKX7 primary roots contained only protoxylem elements, thus resembling the wol mutant of the CRE1/AHK4 receptor gene. We show that CRE1/AHK4 activity is required to establish the CKX7 overexpression phenotype. Several cytokinin metabolites, in particular cis-zeatin (cZ) and N-glucoside cytokinins, were depleted stronger in 35S:CKX7 plants compared with plants overexpressing other CKX genes. Interestingly, enhanced protoxylem formation together with reduced primary root growth was also found in the cZ-deficient tRNA isopentenyltransferase mutant ipt2,9. However, different cytokinins were similarly efficient in suppressing 35S:CKX7 and ipt2,9 vascular phenotypes. Therefore, we hypothesize that the pool of cytosolic cytokinins is particularly relevant in the root procambium where it mediates the differentiation of vascular tissues through CRE1/AHK4. Taken together, the distinct consequences of CKX7 overexpression indicate that the cellular compartmentalization of cytokinin degradation and substrate preference of CKX isoforms are relevant parameters that define the activities of the hormone.
Capacity of deterministic Z-chain relay-interference network (2009)

The wireless multiple-unicast problem is considered over a layered network, where the rates of transmission are limited by the relaying and interference effect. The deterministic model introduced is used to capture the broadcasting and multiple access effects. The capacity region of the Z-chain relay-interference network is fully characterized. In order to solve the problem, we introduce a new achievability scheme based on ldquointerference neutralizationrdquo and a new analysis technique to bound the number of non-interfering (pure) signals.
An Efficient Transition Metal Free Aziridination of Alkenes with Chloramine‐T Using Aqueous H2O2/HBr. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Robust nonparametric regression by controlling sparsity* (2011)

Nonparametric methods are widely applicable to statistical learning problems, since they rely on a few modeling assumptions. In this context, the fresh look advocated here permeates benefits from variable selection and compressive sampling, to robustify nonparametric regression against outliers. A variational counterpart to least-trimmed squares regression is shown closely related to an ℓ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</inf> -(pseudo)norm-regularized estimator, that encourages sparsity in a vector explicitly modeling the outliers. This connection suggests efficient (approximate) solvers based on convex relaxation, which lead naturally to a variational M-type estimator equivalent to Lasso. Outliers are identified by judiciously tuning regularization parameters, which amounts to controlling the sparsity of the outlier vector along the whole robustification path of Lasso solutions. An improved estimator with reduced bias is obtained after replacing the ℓ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</inf> -(pseudo)norm with a nonconvex surrogate, as corroborated via simulated tests on robust thin-plate smoothing splines.
Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency (2021)

Non-covalent inhibitors of the main protease (M<sup>pro</sup>) of SARS-CoV-2 having a pyridinone core were previously reported with IC<sub>50</sub> values as low as 0.018 μM for inhibition of enzymatic activity and EC<sub>50</sub> values as low as 0.8 μM for inhibition of viral replication in Vero E6 cells. The series has now been further advanced by consideration of placement of substituted five-membered-ring heterocycles in the S4 pocket of M<sup>pro</sup> and N-methylation of a uracil ring. Free energy perturbation calculations provided guidance on the choice of the heterocycles, and protein crystallography confirmed the desired S4 placement. Here we report inhibitors with EC<sub>50</sub> values as low as 0.080 μM, while remdesivir yields values of 0.5-2 μM in side-by-side testing with infectious SARS-CoV-2. A key factor in the improvement is enhanced cell permeability, as reflected in PAMPA measurements. Compounds <b>19</b> and <b>21</b> are particularly promising as potential therapies for COVID-19, featuring IC<sub>50</sub> values of 0.044-0.061 μM, EC<sub>50</sub> values of ca. 0.1 μM, good aqueous solubility, and no cytotoxicity.
The Train Communication Network In The Trains Of FS Fleet: Optimisation, Integration And Interoperability Of Railway Functionality (2002)

This paper describes the research, testing, commissioning, and conformance assessment activities carried out by the Italian Railway to introduce a Train Communication Network (TCN) in the railroad vehicles of its fleet. The TCN can be considered as a train infrastructure capable of configuring itself automatically and connecting, through common interfaces, to all the onboard electronic equipment. The TCN transfers a great deal of data along the train, both in cyclical and sporadic modes, allowing realization of new applications and improvement of existing ones.
Simulation of Free Blowing of Polyethylene Terephthalate using a Thermodynamic Induced Crystallisation Model. Free Blowing Simulation (2006)

NonWOS
Ran Binding Protein 9 (RanBP9) is a novel mediator of cellular DNA damage response in lung cancer cells (2016)

Ran Binding Protein 9 (RanBP9, also known as RanBPM) is an evolutionary conserved scaffold protein present both in the nucleus and the cytoplasm of cells whose biological functions remain elusive. We show that active ATM phosphorylates RanBP9 on at least two different residues (S181 and S603). In response to IR, RanBP9 rapidly accumulates into the nucleus of lung cancer cells, but this nuclear accumulation is prevented by ATM inhibition. RanBP9 stable silencing in three different lung cancer cell lines significantly affects the DNA Damage Response (DDR), resulting in delayed activation of key components of the cellular response to IR such as ATM itself, Chk2, γH2AX, and p53. Accordingly, abrogation of RanBP9 expression reduces homologous recombination-dependent DNA repair efficiency, causing an abnormal activation of IR-induced senescence and apoptosis. In summary, here we report that RanBP9 is a novel mediator of the cellular DDR, whose accumulation into the nucleus upon IR is dependent on ATM kinase activity. RanBP9 absence hampers the molecular mechanisms leading to efficient repair of damaged DNA, resulting in enhanced sensitivity to genotoxic stress. These findings suggest that targeting RanBP9 might enhance lung cancer cell sensitivity to genotoxic anti-neoplastic treatment.
Methanol synthesis from CO2and H2using supported Pd alloy catalysts (2022)

A number of Pd based materials have been synthesised and evaluated as catalysts for the conversion of carbon dioxide and hydrogen to methanol, a useful platform chemical and hydrogen storage molecule. Monometallic Pd catalysts show poor methanol selectivity, but this is improved through the formation of Pd alloys, with both PdZn and PdGa alloys showing greatly enhanced methanol productivity compared with monometallic Pd/Al<sub>2</sub>O<sub>3</sub> and Pd/TiO<sub>2</sub> catalysts. Catalyst characterisation shows that the 1 : 1 β-PdZn alloy is present in all Zn containing post-reaction samples, including PdZn/Ga<sub>2</sub>O<sub>3</sub>, with the Pd<sub>2</sub>Ga alloy formed for the Pd/Ga<sub>2</sub>O<sub>3</sub> sample. The heat of mixing was calculated for a variety of alloy compositions with high values determined for both PdZn and Pd<sub>2</sub>Ga alloys, at <i>ca.</i> -0.6 eV per atom and <i>ca.</i> -0.8 eV per atom, respectively. However, ZnO is more readily reduced than Ga<sub>2</sub>O<sub>3</sub>, providing a possible explanation for the preferential formation of the PdZn alloy, rather than PdGa, when in the presence of Ga<sub>2</sub>O<sub>3</sub>.
Improvement of Energy Efficiency in Light Railway Vehicles Based on Power Management Control of Wayside Lithium-Ion Capacitor Storage (2013)

The paper suggests an energy management control strategy of wayside Li-ion capacitor (LiC) based energy storage for light railway vehicles (LRV). The installation of wayside supercapacitor (SC) storage devices, as widely recognized, allows the recovery of the braking energy for increasing the system efficiency as well as a better pantograph voltage profile. A new type of SC, LiC, interfaced with dc-interleaved converter has been presented. This technology has an energy density comparable to batteries and power density much higher than the batteries. The authors propose a control strategy based on the maximum kinetic energy recovery throughout braking operations of the running vehicles. The stored energy comes back to the vehicles during the accelerations. The strategy stays on the knowledge of the state of charge of LiC device and the actual vehicle speeds. In particular, the control algorithm evaluates, in real time, the actual value of LiC voltage and current references on the basis of the vehicles inertial forces and acceleration estimations, taking into account the power losses of the system. Experimental tests made on electromechanical simulator, equipped with a 136-V, 30.5-F LiC module, fully confirm the validity of the suggested control. Finally, experimental characterization of LiC module has been achieved.
Remodeling of Endogenous Mammary Epithelium by Breast Cancer Stem Cells (2012)

Poorly regulated tissue remodeling results in increased breast cancer risk, yet how breast cancer stem cells (CSC) participate in remodeling is unknown. We performed in vivo imaging of changes in fluorescent, endogenous duct architecture as a metric for remodeling. First, we quantitatively imaged physiologic remodeling of primary branches of the developing and regenerating mammary tree. To assess CSC-specific remodeling events, we isolated CSC from MMTV-Wnt1 (mouse mammary tumor virus long-term repeat enhancer driving Wnt1 oncogene) breast tumors, a well studied model in which tissue remodeling affects tumorigenesis. We confirm that CSC drive tumorigenesis, suggesting a link between CSC and remodeling. We find that normal, regenerating, and developing gland maintain a specific branching pattern. In contrast, transplantation of CSC results in changes in the branching patterns of endogenous ducts while non-CSC do not. Specifically, in the presence of CSC, we identified an increased number of branches, branch points, ducts which have greater than 40 branches (5/33 for CSC and 0/39 for non-CSC), and histological evidence of increased branching. Moreover, we demonstrate that only CSC implants invade into surrounding stroma with structures similar to developing mammary ducts (nine for CSC and one for non-CSC). Overall, we demonstrate a novel approach for imaging physiologic and pathological remodeling. Furthermore, we identify unique, CSC-specific, remodeling events. Our data suggest that CSC interact with the microenvironment differently than non-CSC, and that this could eventually be a therapeutic approach for targeting CSC.
The Morphology and Composition of Influenza A Virus Particles Are Not Affected by Low Levels of M1 and M2 Proteins in Infected Cells (2005)

We generated a recombinant influenza A virus (Mmut) that produced low levels of matrix (M1) and M2 proteins in infected cells. Mmut virus propagated to significantly lower titers than did wild-type virus in cells infected at low multiplicity. By contrast, virion morphology and incorporation of viral proteins and vRNAs into virus particles were similar to those of wild-type virus. We propose that a threshold amount of M1 protein is needed for the assembly of viral components into an infectious particle and that budding is delayed in Mmut virus-infected cells until sufficient levels of M1 protein accumulate at the plasma membrane.
ORAN: a basis for an Arabic OCR system (2005)

We present a system called ORAN (offline recognition of Arabic characters and numerals). This system is based on a method called modified MCR (minimum covering run) expression for document images. Using the correspondence between binary images and bipartite graphs, the MCR expression can be found by constructing a minimum covering or maximum matching in the corresponding graph. We use the structural information obtained from this expression to describe the character strokes according to some extracted features. These are obtained after a zoning scheme, where the baseline is detected and the line of text divided into four zones. Reference prototypes for the system are built according to a structural description of characters in some model documents. By this method, we overcome the problem of segmentation that is inherent to Arabic characters, even when they are machine printed or typed. Simple matching of the candidate characters to reference prototypes is performed. A recognition rate of more than 97% is achieved.
Supplemental Table 6 from Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics (2023)

&lt;p&gt;Supplemental Table 6&lt;/p&gt;
Improved Method for the Synthesis of trans-Feruloyl-β-sitostanol (2001)

Phytosterols and phytostanols are known to lower low-density lipoprotein-cholesterol (LDL-C) levels in humans by up to 15%, and at least two products, Benecol and Take Control, are now on the market as naturally derived fatty acid esters of phytostanols (stanol esters) and phytosterols (sterol esters), respectively. A synthetic process was developed to synthesize gram quantities of trans-feruloyl-beta-sitostanol from ferulic acid and beta-sitostanol, with high purity and yields of approximately 60%. The process involves (a) condensation of trans-4-O-acetylferulic acid with the appropriate phytostanol or phytostanol mixture in the presence of N,N-dicyclohexylcarbodiimide and 4-(dimethylamino)pyridine, (b) separation of the trans-4-O-acetylferuloyl products by preparative liquid chromatography, (c) selective deacetylation of the feruloyl acetate, and (d) chromatographic purification of the feruloylated phytostanols. The process was successfully applied to synthesize stanol trans-feruloyl esters from "Vegetable Stanols", a mixture of approximately 70:30 beta-sitostanol and beta-campestanol, in comparable purity and yield.
First Demonstration of Real-time All-Optical Software-Defined Intra-Data Center Star Network Using OFDM and Burst Switching (2013)

We demonstrate the first real-time high-capacity star OFDM-based all-optical intra-data center network using burst switching and OpenFlow-based software-defined networking. It offers efficient flexible bandwidth multi-vendor any-to-any switching and hitless in-service upgrade.