gebhart/patrepeval huggingface dataset:
High-Performance Liquid Chromatography of Complex Mixtures Using Monodisperse Dual-Chemistry Polymer Beads Prepared by a Pore-Size-Specific Functionalization Process. A Single Column Combination of Hydrophobic Interaction and Reversed-Phase Chromatography (1994)

A novel separation medium for HPLC combining hydrophobic interaction and reversed-phase separation modes in a single column has been prepared from monodisperse 10-microns poly-(glycidyl methacrylate-co-ethylene dimethacrylate) beads using a pore-size-specific functionalization process. In this approach, the large pores of each bead were provided with phenyl groups interspersed among hydrophilic functionalities while a much higher surface concentration of hydrophobic phenyl groups was introduced into the small pores. Due to the size-specific character of the modification process, no protein interaction with any highly hydrophobic surface was observed during chromatography. The beads were used for the separation of samples containing both proteins and small hydrocarbon or drug molecules. A plot of log k' against salt concentration in the mobile phase clearly documents the clean hydrophobic interaction mechanism of protein separation and the absence of charged groups while the linear plot of log k' against acetonitrile concentration for numerous compounds demonstrates the reversed-phase separation ability. No decrease of the efficiency of the test column (23,000 plates/m) was observed in long-term experiments during which more than 1000 injections and many changes between the modes were performed.
Three-Coil Wireless Charging System for Metal-Cover Smartphone Applications (2019)

A three-coil wireless charging system is proposed for full metal-cover smartphone applications. Considering the space limitation and other antennas in the smartphone, the receiver coil embedded in the smartphone is designed to be miniaturized as 16 mm × 65 mm. By integrating a series capacitance at the end of the 2-mm width narrow horizontal slot loading on the metal cover, the metal cover is converted to a relay coil of the three-coil system and wireless power transfer (WPT) through the metal cover is thus achieved. A prototype of the proposed three-coil system has been built and WPT through metal cover has been validated via experiment. The experimental results show that the prototype achieves 5 W output power with 71% coil-to-coil efficiency.
An efficient one-pot method for the preparation of polysubstituted benzothiophenes (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn efficient one-pot method for the preparation of polysubstituted benzothiophenesStephen L. Buchwald and Qun FangCite this: J. Org. Chem. 1989, 54, 12, 2793–2797Publication Date (Print):June 1, 1989Publication History Published online1 May 2002Published inissue 1 June 1989https://pubs.acs.org/doi/10.1021/jo00273a006https://doi.org/10.1021/jo00273a006research-articleACS PublicationsRequest reuse permissionsArticle Views696Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Supercontinuum generation beyond 2µm in GeSbS waveguides (2016)

We investigate nonlinear spectral broadening in GeSbS chalcogenide waveguides. Nonlinear phase shift of self-phase modulation induced-broadened spectrum allows us to extract a nonlinear parameter of ~7 W−1/m. Supercontinuum is generated using 500fs pulses, and a 14 fold spectral broadening with respect to the input spectrum is observed. The broadened spectrum spans 1280 nm to 2120 nm at the −30 dB level, representing broadening close to an octave.
The Biopotentials and Measuring Devices (2012)

Many organs in the human body, produces many different types of the electric activity, such as the muscle groups, heart, brain and eyes. These electric activities are also called biopotentials. Measurement of the biopotentials from the human body can indicated vital clues as to normal or pathological functions of the organs. Biopotential signals are small in amplitude and consists of very low frequencies. Therefore, the signals need to be amplified and filtered to make them compatible with devices such as displays, recorders, or analog to digital converters for computerized equipment. In addition, biopotential measurements are corrupted by environmental and biological sources of interference. Amplifiers and filters adequate to measure these signals have to satisfy very specific requirements. This study reviews the origins, acuisition of biopotentials, and design of the medical instruments used in biopotential measurement. [Archives Medical Review Journal 2012; 21(3.000): 174-188]
Methyl 2-[4-(2-chloroethyl)-2,3-dihydro-7-nitroquinoxalin-1-yl]benzoate from intramolecular cyclization of a nitroaromatic mustard (1989)

C18H18CIN3O4, Mr = 375.81, orthorhombic, P212121, a = 11.000 (3), b = 8.023 (2), c = 19.316 (5) A, V = 1704.68 A3, Z = 4, Dm = 1.46 (1), Dx = 1.417 g cm-3, Mo Kalpha, lambda = 0.71069 A, mu = 1.82 cm-1, F(000) = 760, T = 293 (1) K, R = 0.051 for 985 [I greater than 2.5 sigma(I)] reflections. X-ray analysis confirms that the nitroaromatic mustard methyl N-(2-[bis(2-chloroethyl)amino]- 5-nitrophenyl)anthranilate undergoes rapid intramolecular cyclization, but the product is the 7-nitro rather than the 6-nitro derivative previously reported [Chambers & Denny (1986).
P‐131: Multi‐Color Cholesteric Liquid Crystal Film by Fixing Helical Pitch with Reactive Mesogen (2010)

Abstract We propose a multi‐color cholesteric liquid crystal (CLC) film in a single‐layered configuration with reactive mesogen (RM). The cholesteric pitches are controlled by temperature and memorized by photo‐polymerization of the KM. Using the multi‐pitch stabilization in a single layer, multicolor CLC display was obtained without any additional components.
A New Adaptive Reconfigurable Bandpass Filter with Flexible Resonance Control (2018)

A new adaptive reconfigurable bandpass filter (BPF) has been proposed in this paper. It has the frequency tuning capability of a normal reconfigurable filter, as well as the ability to change the filter order and bandwidth. The proposed filter structure is divided into two parts; the core filter and the adaptive resonators. The core filter, whose resonant frequencies are always in the filter's passband, is analyzed using an even-odd mode method. The resonant frequencies from the adaptive resonators are then compared to the ones from the even-odd modes in the core filter. It is found that when the resonant frequencies of the adaptive resonators match those of the even and odd modes, the filter order is two and a narrow bandwidth is obtained. If both the adaptive resonator frequencies are far removed from the even-odd mode frequencies of the core filter, a forth order wide band response is observed. In between these two cases, a third order filter with an intermediate bandwidth can be obtained. Another advantage of the proposed BPF is that its response contains two transmission zeroes on either side of the passband, improving out-of-band rejection. This mechanism is a result of the adaptive resonators creating a bandstop structure in the rejection band. To verify the discussion, a prototype filter has been experimentally implemented. It demonstrates flexibility in frequency tuning, filter order switching and bandwidth control.
D-Amino acid residue in a defensin-like peptide from platypus venom: effect on structure and chromatographic properties (2005)

The recent discovery that the natriuretic peptide OvCNPb (Ornithorhynchus venom C-type natriuretic peptide B) from platypus (Ornithorynchus anatinus) venom contains a D-amino acid residue suggested that other D-amino-acid-containing peptides might be present in the venom. In the present study, we show that DLP-2 (defensin-like peptide-2), a 42-amino-acid residue polypeptide in the platypus venom, also contains a D-amino acid residue, D-methionine, at position 2, while DLP-4, which has an identical amino acid sequence, has all amino acids in the L-form. These findings were supported further by the detection of isomerase activity in the platypus gland venom extract that converts DLP-4 into DLP-2. In the light of this new information, the tertiary structure of DLP-2 was recalculated using a new structural template with D-Met2. The structure of DLP-4 was also determined in order to evaluate the effect of a D-amino acid at position 2 on the structure and possibly to explain the large retention time difference observed for the two molecules in reverse-phase HPLC. The solution structures of the DLP-2 and DLP-4 are very similar to each other and to the earlier reported structure of DLP-2, which assumed that all amino acids were in the L-form. Our results suggest that the incorporation of the D-amino acid at position 2 has minimal effect on the overall fold in solution.
110th Anniversary: High Performance Carbon Molecular Sieve Membrane Resistance to Aggressive Feed Stream Contaminants (2019)

Carbon molecular sieve (CMS) membranes show high performance for various critical gas pair separations with excellent scalable manufacturability. For practical applications it is important to evaluate such membranes for resistance to contaminants possibly present in feed streams related to an onboard inert gas generation system (OBIGGS) for aerospace applications. Here we report the performance of CMS membranes prepared by optimized dual temperature secondary oxygen doping (DTSOD) in the presence of aggressive contaminants, potentially in the bleed air of aircraft. Such feed can be used to eliminate the need for a separate compressor in membrane systems to create nitrogen enriched stream for fuel tank inerting, and we considered this case using simulated engine bypass air. Our CMS membranes were exposed to different humidity levels, combinations of gaseous contaminants (denoted as Class ‘A’), and ozone to study the membrane performance for O2/N2 separation with time at high temperatures. The CMS shows a robust nature under such aggressive feed conditions especially at or above 160 °F (71 °C) under steady-state operation with an attractive performance under long-term exposure.
A universal smart transducer interface: TTP/A (2002)

The primary goal of a universal smart transducer interface is the provision of a framework that helps to reduce the complexity of large distributed real-time systems by introducing precisely specified (in the value domain and in the temporal domain) and small interfaces between smart transducers and their users. This paper presents a universal smart transducer interface that can be implemented on top of different real-time communication systems. It integrates a time-triggered communication protocol with an interface file system that provides the sources and sinks for the exchanged information. The final section discusses an implementation of this interface on a low cost (less than 1 $) commercial off the shelf microcontroller.
Expression and Processing of Proteins Encoded by the Saccharomyces Retrotransposon Ty5 (2001)

Retroelements (retrotransposons and retroviruses) have two genes in common: gag, which specifies structural proteins that form a virus or virus-like particle, and pol, which specifies catalytic proteins required for replication. For many retroelements, gag and pol are present on separate reading frames. Their expression is highly regulated, and the ratio of Gag to Pol is critical for retroelement replication. The Saccharomyces retrotransposon Ty5 contains a single open reading frame, and we characterized Gag and Pol expression by generating transpositionally active Ty5 elements with epitope tags at the N terminus or C terminus or within the integrase coding region. Immunoblot analysis identified two Gag species (Gag-p27 and Gag-p37), reverse transcriptase (Pol-p59), and integrase (Pol-p80), all of which are largely insoluble in the absence of urea or ionic detergent. These proteins result from proteolytic processing of a polyprotein, because elements with mutations in the presumed active site of Ty5 protease express a single tagged protein (Gag-Pol-p182). Protease mutants are also transpositionally inactive. In a time course experiment, we monitored protein expression, proteolytic processing, and transposition of a Ty5 element with identical epitope tags at its N and C termini. Both transposition and the abundance of Gag-p27 increased over time. In contrast, the levels of Gag-p37 and reverse transcriptase peaked after approximately 14 h of induction and then gradually decreased. This may be due to differences in stability of Gag-p27 relative to Gag-p37 and reverse transcriptase. The ratio of Ty5 Gag to Pol averaged 5:1 throughout the time course experiment, suggesting that differential protein stability regulates the amounts of these proteins.
Computing Transportation Voronoi Diagrams in Optimal Time (2005)

We present the first time-optimal algorithm for computing the Voronoi Diagram under the metric induced by a transportation network with discrete entry and exit points. For input with n sites, k stations, and e transportation lines, the algorithm computes the Voronoi Diagram in O ( (n + k) log(n + k)+e) time. 1 Introduction and related work Shortest Path Maps (SPM) and Voronoi Diagrams are well known geometric tools for answering distance related queries. The SPM is a subdivision of space, which allows finding the shortest path from a source
Vessel-Targeting Nanoclovers Enable Noninvasive Delivery of Magnetic Hyperthermia–Chemotherapy Combination for Brain Cancer Treatment (2021)

Despite being promising, the clinical application of magnetic hyperthermia for brain cancer treatment is limited by the requirement of highly invasive intracranial injections. To overcome this limitation, here we report the development of gallic acid-coated magnetic nanoclovers (GA-MNCs), which allow not only for noninvasive delivery of magnetic hyperthermia but also for targeted delivery of systemic chemotherapy to brain tumors. GA-MNCs are composed of clover-shaped MNCs in the core, which can induce magnetic heat in high efficiency, and polymerized GA on the shell, which enables tumor vessel-targeting. We demonstrate that intravenous administration of GA-MNCs following alternating magnetic field exposure effectively inhibited brain cancer development and preferentially disrupted tumor vasculature, making it possible to efficiently deliver systemic chemotherapy for further improved efficacy. Due to the noninvasive nature and high efficiency in killing tumor cells and enhancing systemic drug delivery, GA-MNCs have the potential to be translated for improved treatment of brain cancer.
A Cytosolic, Gαq- and βγ-insensitive Splice Variant of Phospholipase C-β4 (1998)

Phospholipase C (PLC)-beta4 has been considered to be a mammalian homolog of the NorpA PLC, which is responsible for visual signal transduction in Drosophila. We reported previously the cloning of a cDNA encoding rat phospholipase C-beta4 (PLC-beta4) (Kim, M. J., Bahk, Y. Y., Min, D. S., Lee, S. J., Ryu, S. H., and Suh, P.-G. (1993) Biochem. Biophys. Res. Commun. 194, 706-712). We report now the isolation and characterization of a splice variant (PLC-beta4b). PLC-beta4b is identical to the 130-kDa PLC-beta4 (PLC-beta4a) except that the carboxyl-terminal 162 amino acids of PLC-beta4a are replaced by 10 distinct amino acids. The existence of PLC-beta4b transcripts in the rat brain was demonstrated by reverse transcription-polymerase chain reaction analysis. Immunological analysis using polyclonal antibody specific for PLC-beta4b revealed that this splice variant exists in rat brain cytosol. To investigate functional differences between the two forms of PLC-beta4, transient expression studies in COS-7 cells were conducted. We found that PLC-beta4a was localized mainly in the particulate fraction of the cell, and it could be activated by Galphaq, whereas PLC-beta4b was localized exclusively in the soluble fraction, and it could not be activated by Galphaq. In addition, both PLC-beta4a and PLC-beta4b were not activated by G-protein betagamma-subunits purified from rat brain. These results suggest that PLC-beta4b may be regulated by a mechanism different from that of PLC-beta4a, and therefore it may play a distinct role in PLC-mediated signal transduction.
Hybrid sparse/diffuse channels: A new model and estimators for wideband channels (2011)

While purely sparse channel models have been recently investigated for underwater acoustic channels, experimental propagation data suggests that the channel is more complex. Thus, herein we propose a novel channel model based on both diffuse and sparse components. Tailored to this hybrid model, channel estimators are designed for different scenarios which differ in the amount of side information available at the receiver. The proposed channel estimation methods are compared to unstructured and purely sparse estimators. The numerical results show that the new channel estimation schemes considerably improve the estimation accuracy and the bit error rate performance over conventional channel estimators. Further, a mean squared error analysis of the proposed estimators is conducted in two asymptotic regimes (high SNR and low SNR) enabling a simple characterization and thus comparison of the proposed estimators.
Extending a traditional OS using object-oriented techniques (1996)

This paper describes a new object infrastructure designed for tightly-coupled distributed systems. The infrastructure includes an object model, interface-to-C++ translator, an object request broker (ORB) based on the CORBA architecture model, and a transport layer. The infrastructure allows the use of multiple data marshalling handlers, includes object recovery features, and provides remote communication through a mechanism called xdoors.

The object infrastructure has been used to extend the SolarisTM operating system into a prototype clustered operating system called Solaris MC. This illustrates how the CORBA object model can be used to extend an existing UNIX implementation into a distributed operating system. It also shows the advantages of defining strong kernel component interfaces in the IDL interface definition language. Finally, Solaris MC illustrates how C++ can be used for kernel development, coexisting with previous code.
Tolerable toxicity after repeated intravaginal administration of IL-7-Fc. from Intravaginal Administration of Fc-Fused IL7 Suppresses the Cervicovaginal Tumor by Recruiting HPV DNA Vaccine-Induced CD8 T Cells (2023)

&lt;p&gt;Supplementary Table 1. Tolerable toxicity after repeated intravaginal administration of IL-7-Fc. Information of detailed materials and methods, and supplementary figure legends are contained.&lt;/p&gt;
Fracture Mechanics and Testing of Interface Adhesion Strength in Multilayered Structures – Application in Advanced Solar PV Materials and Technology (2016)

Quantitative characterization techniques based on fracture mechanics were proposed and used to examine the interface strength in multilayered structures. Novel in situ micro-fracture testing for nanolayers inside a Scanning Electron Microscope (SEM) is developed to observe fracture evolution during bending deformation of nanolayered films. Other quantitative technique on interface fracture mechanics has been the 4-point bending or double cantilever beam bending methods. In this paper we will discuss about these two techniques and their applications. In particular, the Double Cantilever Beam bending test method using Delaminator v8.2 Adhesion testing system has been used to quantify the adhesion strength between the Solar PV backsheet and encapsulant. The environmental conditions in tropical countries makes the photovoltaics components vulnerable to salt mist and water vapour as well as acid penetration. Under moisture condition, the hydrolysis reaction of water vapour with backsheet materials release acetic acid, causing delamination and further corrosion of the encapsulant and inter-metallic connectors on solar cells by the salt mist leading to electrical shorts, heat accumulation and fire. Understanding the interface strength between these two materials and its degradation with typical environments in tropical and near-ocean regions is instrumental to enable robust and reliable solar PV technology for such regions.
LN-6: a monoclonal antibody to vimentin expressed in non-hematopoietic mesenchymal cells and derived tumors and reactive in B5-fixed, paraffin-embedded tissues. (1989)

We generated a monoclonal antibody (MAb), designated LN-6, directed against human vimentin, which retains its immunoreactivity in B5-fixed, paraffin-embedded tissues. Like other anti-vimentin MAb, LN-6 was found to be reactive with a wide spectrum of human sarcomas and normal cells of mesenchymal derivation. However, unlike other similar reagents, LN-6 was unreactive with normal and malignant human lymphoid cells and therefore displays a more restricted immunoreactivity. Because of its ability to stain routinely processed pathological tissues and its marked reactivity with human sarcomas, LN-6 is a unique reagent for the immunohistochemical diagnosis of human cancer.
Surgical Correction of Cryptotia with V-Y Advancement of a Temporal Triangular Flap (2005)

The main advantages of this proposed technique are simple and easy design, provision of enough skin to the upper and posterior portions of the auricle, sufficient depth of the auriculocephalic sulcus, correction of cartilage deformities with unrestricted access, and no additional skin grafting. Problems encountered were the development of a visible scar on the donor site and lowered hairline because of advancement of the temporal triangular flap.
Double-Sided Process for MEMS SOI Sensors With Deep Vertical Thru-Wafer Interconnects (2018)

This paper reports an approach for co-fabrication of silicon-on-insulator (SOI) sensors with low-resistance vertical electrical interconnects in thick (up to 600 μm) wafers. The thru-wafer interconnects double-sided (TWIDS) process is based on bottom-up seedless copper electroplating, and allows for voids-free features and high aspect ratio (wafer thickness to copper diameter ratio of 10:1). This work describes the design trade-offs, process flow, and characterization of interconnects. TWIDS technology is compatible with a standard SOI micro-electro-mechanical systems (MEMS) fabrication process and is applicable for micro sensors, such as accelerometers, gyroscopes, resonators, and RF MEMS devices, as well as for the 3-D MEMS assemblies. As a demonstration of potential applications, miniature toroidal ring gyroscopes were fabricated using the TWIDS process. The experimental characterization showed that the low-resistance interconnects with low parasitic losses are suitable for integration with capacitive-detection sensors. In addition, the mechanical stability of the interconnects is discussed in this paper, and a method to enhance structural rigidity by means of filling the insulating gaps with Parylene C is demonstrated.