gebhart/patrepeval huggingface dataset:
Phase stable rare earth garnets (2023)

A transparent ceramic according to one embodiment includes a rare earth garnet comprising A.sub.hB.sub.iC.sub.jO.sub.12, where h is 3.+-.10%, i is 2.+-.10%, and j is 3.+-.10%. A includes a rare earth element or a mixture of rare earth elements, B includes at least one of aluminum, gallium and scandium, and C includes at least one of aluminum, gallium and scandium, where A is at a dodecahedral site of the garnet, B is at an octahedral site of the garnet, and C is at a tetrahedral site of the garnet. In one embodiment, the rare earth garment has scintillation properties. A radiation detector in one embodiment includes a transparent ceramic as described above and a photo detector optically coupled to the rare earth garnet.
Re-identification of Affymetrix HG-U133 probe sequences using BLAST alignment and its application to distinguishing lung cancer from normal lung expression profiles (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

845 

Affymetrix HG-U133-Plus2 has 54,675 probe sets, each consisting of eleven 25-mer probes. Each probe set is designated by an Affymetrix ID together with a GenBank accession ID. From this accession number, extensive annotations can be derived, including Unigene and chromosome location mapping. The identity of the genes and subsequent array analyses are therefore crucially dependent on the accuracy of the accession IDs provided by Affymetrix. Here we provide a complete BLAST analysis of all 604,258 probe sequences and generated accession numbers with the best alignments based on the following criteria: complete match of the 25-mer sequences, correct strand orientation, preference of RefSeq and GenBank sequences, preference of sequences belonging to Unigene clusters. The resulting accession numbers were then regrouped into their original probe sets and their Unigene IDs were compared to those derived from the original accession numbers. Two-thirds (67%) of the Unigene IDs were identical; 2% were different, 7% were new (i.e. the new accession IDs belonged to a Unigene cluster but not the accessions from Affymetrix); 18% no longer belonged to a Unigene cluster, including 4% (of total) with the wrong chromosomal orientation; finally 6% had no Unigene IDs in both cases. Additionally, in the various groups, 3% of the probe sets had probes matching to 2 or more Unigene clusters, including 1% (of total) that represented alternative splice variants, and another 3% had some minor degree of cross-hybridization. Thus 20% of the genes provided by Affymetrix turned out to be different from what they were designed to be. This analysis also provided the exact probe locations within the gene for a subset of the probe sets, namely those that belonged to the RefSeq database. As an application to lung cancer expression profiles, four datasets comprising together more than 200 HG-U133 arrays were analyzed in a comparison of tumor vs normal samples. In all arrays, the signal strength showed an inverse relationship to the distance from the 3′ end, probably reflecting the efficiency of reverse transcription in the probe labeling process. However, the percent present calls were not correlated to this distance, suggesting that the validity of the data is fairly uniform across all probe locations with the genes. More importantly, 13% of the differentially regulated genes (tumor vs normal) were from probe sets that had been misidentified by Affymetrix. Without this BLAST analysis, these genes would have been falsely interpreted as being involved in the genesis of lung cancer. These results therefore demonstrate the importance of verifying and reannotating microarray gene lists with each new release of the human genome sequence in order to ensure accuracy of downstream array analyses.
Supplementary Figure 1 from Regulation of the Embryonic Morphogen Nodal by Notch4 Facilitates Manifestation of the Aggressive Melanoma Phenotype (2023)

Supplementary Figure 1 from Regulation of the Embryonic Morphogen Nodal by Notch4 Facilitates Manifestation of the Aggressive Melanoma Phenotype
<title>DC Kerr measurement in a silica channel waveguide</title> (1996)

We describe interferometric measurements of the DC Kerr susceptibilities in an SiO<SUB>2</SUB>-GeO<SUB>2</SUB> channel waveguide. The measured magnitude of (chi) <SUB>1111</SUB><SUP>(3</SUP>)(-(omega) ; (omega) , 0,0) equals 2.44 +/- 0.2 X 10<SUP>-22</SUP> m<SUP>2</SUP>/V<SUP>2</SUP> is comparable to the previously measured optical Kerr susceptibility. However, the ratio of nonlinear tensor elements (chi) <SUB>1111</SUB><SUP>(3</SUP>)/(chi) <SUB>1122</SUB><SUP>(3</SUP>) equals 1.1 for the DC Kerr effect differs from that observed in the optical Kerr effect where (chi) <SUB>1111</SUB><SUP>(3</SUP>)/(chi) <SUB>1122</SUB><SUP>(3</SUP>) equals 3. We provide theoretical interpretation for this difference in the polarization dependence.
First Industrial Results of Alglass Sun Operation (2008)

The paper presents the results of some of the first industrial references obtained for ALGLASS SUN burner, the latest technology developed by AIR LIQUIDE for large glass furnaces. This combustion system relies on a large separation of the fuel and oxidant streams and on the adjustable distribution of the oxidant in three various injections. After having demonstrated in AIR LIQUIDE pilot furnace the minimization of NOx emissions with such a technology and its flexibility regarding the control of flame length and heat transfer, we have confirmed these advantages through two first industrial references: an oxy boosting in a regenerative air firing furnace producing figured glass and a new full oxy firing furnace manufacturing borosilicate glass.
Supplementary Figure 6 from CUL4A Induces Epithelial–Mesenchymal Transition and Promotes Cancer Metastasis by Regulating ZEB1 Expression (2023)

&lt;p&gt;PDF file - 243K, Supplemental Figure 6. ZEB1 mediates CUL4A-induced EMT, stemness and metastasis.&lt;/p&gt;
Keynote II: Integrated modeling challenges in extreme-scale computing (2011)

Summary form only given. Extreme-scale computer systems of the future target orders of magnitude improvement in performance over current large-scale server or supercomputing systems. These targets must be achieved for the same power consumption and reliability at the system level. Accomplishing the goal requires investment in new generation integrated pre-silicon modeling environments that allow rapid exploration of power, performance and reliability tradeoffs. In this talk, I present an overview of the alluded modeling challenges and methods of hierarchical abstractions to ease the pre-silicon simulation bottleneck.
Glutathione reductase reduces chromium VI to cytotoxic metabolites in isolated rat hepatocytes (2001)

Chromium (VI) is an environmental and occupational carcinogen, and it is accepted that intracellular reduction is necessary for DNA damage and cytotoxicity. We have investigated the interaction of Cr(VI) with hepatocytes in vitro to determine the contribution of various hepatic enzymes to the reduction of Cr(VI). Cr(VI) caused a dose-dependent decrease in cell viability and intracellular reduced glutathione (GSH) levels between 100 and 500 microM within 3 h exposure of hepatocytes. Both DT-diaphorase and cytochrome P450 play only a minor role in detoxifying Cr(VI) and/or its metabolites. (GSH) appears to act as a non-enzymatic reductant, reducing Cr(VI) to a toxic form. The evidence for this is two-fold. Firstly, GSH was depleted during the metabolism of Cr(VI) and, secondly, pretreatment of the cells with diethylmaleate to deplete GSH levels, partially protected the cells from Cr(VI) toxicity. Glutathione reductase appears to play an important role in the enzymatic reduction of Cr(VI) as inhibition of this enzyme by carmustine (BCNU) markedly protected the cells from cytotoxicity.
Low Voltage Nanoelectromechanical Switches Based on Silicon Carbide Nanowires (2010)

We report experimental demonstrations of electrostatically actuated, contact-mode nanoelectromechanical switches based on very thin silicon carbide (SiC) nanowires (NWs). These NWs are lithographically patterned from a 50 nm thick SiC layer heteroepitaxially grown on single-crystal silicon (Si). Several generic designs of in-plane electrostatic SiC NW switches have been realized, with NW widths as small as approximately 20 nm and lateral switching gaps as narrow as approximately 10 nm. Very low switch-on voltages are obtained, from a few volts down to approximately 1 V level. Two-terminal, contact-mode "hot" switching with high on/off ratios (>10(2) or 10(3)) has been demonstrated repeatedly for many devices. We find enhanced switching performance in bare SiC NWs, with lifetimes exceeding those based on metallized SiC NWs.
Key role of chromosomal mobile genetic elements transferring by conjugation in the dissemination of antimicrobial resistance in Streptococcus suis (2019)

International audience
Improved polymer cladding for eye safer fiber lasers (2019)

Fiber lasers rely on clad pump architectures where double clad designs are used. Currently, polymers are used successfully as pump claddings on Yb-doped laser fibers. In order to transition to resonantly pumped fiber lasers at eye safer wavelengths, polymer pump claddings must have low absorption at those wavelengths. There is currently no suitable low index, low absorption, thermally stable, and high thermal conductivity polymer to act as a low-index coating. This work presents a new class of polymers, termed fluorinated polymer composites (FPCs), which possess improved thermal properties. The FPCs are fabricated by incorporating ceramic nanoparticles into fluorinated polymers. Ultimately, the FPCs could enable further use of fiber lasers at commonly used wavelengths, as well as at eye-safer wavelengths.
Dissociated Pulmonary Vein Arrhythmia: (2003)

Dissociation as the endpoint of PV disconnection was observed in 12% of PVs. Due to the capricious nature of this activity, the actual incidence is almost certainly higher. The dissociated venous rhythm usually is slow and, less commonly, is rapid and repetitive.
Photoionization Dynamics in Pure Helium Droplets (2007)

The photoionization and photoelectron spectroscopy of pure He droplets were investigated at photon energies between 24.6 eV (the ionization energy of He) and 28.0 eV. Time-of-flight mass spectra and photoelectron images were obtained at a series of molecular beam source temperatures and pressures to assess the effect of droplet size on the photoionization dynamics. At source temperatures below 16 K, where there is significant production of clusters with more than 10(4) atoms, the photoelectron images are dominated by fast electrons produced via direct ionization, with a small contribution from very slow electrons with kinetic energies below 1 meV arising from an indirect mechanism. The fast photoelectrons from the droplets have as much as 0.5 eV more kinetic energy than those from atomic He at the same photon energy. This result is interpreted and simulated within the context of a "dimer model", in which one assumes vertical ionization from two nearest-neighbor He atoms to the attractive region of the He2+ potential energy curve. Possible mechanisms for the slow electrons, which were also seen at energies below IE(He), are discussed, including vibrational autoionizaton of Rydberg states comprising an electron weakly bound to the surface of a large HeN+ core.
Limited Contribution of Humoral Immunity to the Clearance of Measles Viremia in Rhesus Monkeys (2004)

The development of an improved vaccine for controlling measles virus (MV) infections in the developing world will require an understanding of the immune mechanisms responsible for the clearance of this virus. To evaluate the role of humoral immunity in the containment of MV, rhesus monkeys were treated at the time of MV challenge with either anti-CD20 monoclonal antibody (MAb) infusion, to deplete B lymphocytes, or both anti-CD20 and anti-CD8 MAb, to deplete both B lymphocytes and CD8+ effector T lymphocytes. Although the MV-specific antibody response in CD20+ lymphocyte-depleted monkeys was delayed by >1 week, the kinetics of MV clearance did not differ from those for monkeys that received control MAb. Furthermore, unusual clinical sequelae of MV infection were not observed in these monkeys. In contrast, MV-infected rhesus monkeys depleted of both CD20+ and CD8+ lymphocytes had a prolonged duration of viremia and developed a desquamating skin rash. These findings indicate that humoral immunity plays a limited role in the control of MV replication in an MV-naive individual and suggest that new measles vaccination strategies should focus on the elicitation of cell-mediated immune responses, in addition to neutralizing antibodies, to facilitate rapid elimination of locally replicating virus.
Size-Selected Nanoparticle Chemistry:  Kinetics of Soot Oxidation (2001)

A new experimental method has been developed to conduct surface chemistry and extract surface kinetic rates on size-selected nanoparticles. The method utilizes a tandem differential mobility analyzer (TDMA) technique in which monodisperse particles are selected from a polydisperse aerosol input stream and then subjected to chemical processing. The change in particle size is measured and used to determine kinetic information for the relevant surface reaction. The method has been applied to measure the oxidation rate of soot in air over the temperature range 800−1120 °C. Soot was generated in situ using an ethylene diffusion flame and sent to a differential mobility analyzer (DMA) to extract monodisperse particles. Three initial particle sizes of 40, 93, and 130 nm mobility diameter were subjected to oxidation in a high-temperature flow reactor, and the resulting change in particle size was measured with a second DMA. The measured size decreases were fit to a model utilizing a modified Arrhenius expression for the rate of decrease: Ḋp = −AnmT1/2 exp(−Ea/(RT)). The fit yielded an activation energy of Ea = 164 kJ mol-1 with a different preexponential factor, Anm, for each initial particle size. The size-decrease rates, and therefore the preexponential factors, differed by a factor of 1.7 between the 40 and 130 nm particles, with the 130 nm particles decreasing faster than the 40 or 93 nm particles. This may be the result of several factors including different effective densities or different soot particle compositions. The current experiments are the first measurements of the soot oxidation rate to be performed on size-selected, freshly generated soot particles using online aerosol techniques. Our results agree well with previous work over the temperature range covered, which is somewhat surprising given the wide range of techniques and materials previously studied in the effort to understand soot oxidation.
Improving plant stress tolerance and yield production: is the tonoplast aquaporin SlTIP2;2 a key to isohydric to anisohydric conversion? (2008)

Anisohydric plants are thought to be more drought tolerant than isohydric plants. However, the molecular mechanism determining whether the plant water potential during the day remains constant or not regardless of the evaporative demand (isohydric vs anisohydric plant) is not known. Here, it was hypothesized that aquaporins take part in this molecular mechanism determining the plant isohydric threshold. Using computational mining a key tonoplast aquaporin, tonoplast intrinsic protein 2;2 (SlTIP2;2), was selected within the large multifunctional gene family of tomato (Solanum lycopersicum) aquaporins based on its induction in response to abiotic stresses. SlTIP2;2-transformed plants (TOM-SlTIP2;2) were compared with controls in physiological assays at cellular and whole-plant levels. Constitutive expression of SlTIP2;2 increased the osmotic water permeability of the cell and whole-plant transpiration. Under drought, these plants transpired more and for longer periods than control plants, reaching a lower relative water content, a behavior characterizing anisohydric plants. In 3-yr consecutive commercial glasshouse trials, TOM-SlTIP2;2 showed significant increases in fruit yield, harvest index and plant mass relative to the control under both normal and water-stress conditions. In conclusion, it is proposed that the regulation mechanism controlling tonoplast water permeability might have a role in determining the whole-plant ishohydric threshold, and thus its abiotic stress tolerance.
Nonlinear Optics Using Atomic Coherence Effects (1996)

Get PDF Email Share Share with Facebook Share on X Post on reddit Share with LinkedIn Add to Mendeley Add to BibSonomy Share with WeChat Get Citation Copy Citation Text Maneesh Jain, Hui Xia, Guang-Yu Yin, Andrew Merriam, and S. E. Harris, "Nonlinear Optics Using Atomic Coherence Effects," Optics & Photonics News 7(12), 45-47 (1996) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Generating movie-quality animated graphics with massively parallel computers (2003)

The author begins by discussing massively parallel computers and hypercube theory. Issues such as single-instruction multiple-data (SIMD) versus multiple-instruction multiple-data (MIMD) and 32 versus 64 bits are discussed. Present and future aspects of animated graphics with massively parallel computers are also discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Multichannel Inverse Filtering of Multiexciter Distributed Mode Loudspeakers for Wave Field Synthesis (2002)

cote interne IRCAM: Corteel02a
Envisioning a Cyber-Security Incident Managed Campus Environment (2020)

This vision paper posits the need for a managed cyber-security incident response requirement for the main campus of the University of Technology, Jamaica. Since the COVID-19 pandemic, the institution has pivoted to a significant online offering for the teaching and learning outcomes for its students. The paper provides unique summary perspectives of the cyber-security incident challenges and opportunities within a university operating in a developing country. These concerns are raised to motivate similar educational institutions, as well as small and medium size organizations, during this pandemic.
Techniques To Reduce Power In Fast Wide Memories (1994)

Memories contain large arrays with high capacitance bitlines and IO lines. To reduce the power of memory accesses we limit the swings on these by controlling the time the lines are driven by using a replica feedback. The swings are set to 10% of the supply over a wide range of process and operating conditions. Introduction Memory power is an important component of the power budget in today&amp;apos;s electronic systems. This paper looks at circuit techniques that can be used to reduce the power requirements of a wide access width memory while having minimum effect on its access time. In CMOS memories the access path can be broken into two parts: from address to local wordline select, and from local wordline to sensed data. It is usually the latter half of the access (which involves driving the bitlines and local bus lines and sensing them) that consume the most power. These lines are heavily loaded and thus require a large amount of energy each time they are changed. While various techniques...
Adalimumab Induction Dose Reduces Hospitalization Risk in Patients With Ulcerative Colitis During the First 8 Weeks of Therapy (2012)

Analysis of data from 2 double-blind, placebo controlled trials (ULTRA 1 and 2) revealed that adalimumab (ADA) maintenance therapy reduces hospitalization in patients with moderate to severe ulcerative colitis (UC) through Week 52.1 The impact of ADA induction dosing on hospitalization and colectomy has not yet been reported. We assessed the effect of a 160/80/40 mg ADA induction regimen (160 mg at Week 0 and 80 mg at Week 2 followed by adalimumab 40 mg every other week [eow] at Week 4 and Week 6) on the risk of hospitalizations (all-cause, UC-related, and UC- or drug-related) and colectomy during the first 8 weeks of these 2 trials. The pooled dataset included 963 patients (480 ADA, 483 placebo [PBO]). Hospitalization and colectomy events were based on safety reports reviewed by 2 gastroenterologists who were blinded to treatment. Because the exposure was similar between treatment groups, the risk of hospitalizations and colectomies between the groups was compared using Chi-square tests. Significant reductions in the risk of all-cause (40%), UC-related (50%), and UC- or drug-related (47%) hospitalizations were observed in the ADA group compared with PBO (table, P < .05 for all). Although not statistically significant, the relative risk for colectomy was lower in the ADA group compared with PBO (relative risk: 0.8, P < .770). Patients who received 160/80/40 mg ADA induction dosing had a significantly lower risk of all-cause, UC-related, and UC- and drug-related hospitalizations compared with PBO during the first 8 weeks of therapy. The incidence of colectomy was non-significantly lower in patients receiving ADA induction therapy vs. PBO. These data further support a favorable benefit/risk profile of ADA in UC.
Solving a 112-bit prime elliptic curve discrete logarithm problem on game consoles using sloppy reduction (2012)

We describe a cell processor implementation of Pollard’s rho method to solve discrete logarithms in groups of elliptic curves over prime fields. The implementation was used on a cluster of PlayStation 3 game consoles to set a new record. We present in detail the underlying single instruction multiple data modular arithmetic.
Microwave-assisted synthesis of magnetite nanoparticles possessing superior magnetic properties (2018)

The improved one-step microwave-assisted preparation method for small (5–7 nm) magnetite (Fe 3 O 4 ) nanoparticles possessing saturation magnetization values (97–98 emu g) close to that of bulk magnetite using oleic acid as the coating agent has been developed.
Study on the Conformation of an Isopropyl-Substituted Furylfulgide. Photochromic Coloring Reaction and Thermal Racemization (1996)

Abstract The conformations of the E-forms of photochromic furylfulgides with a methyl substituent (1E) and an isopropyl substituent (2E) were investigated by X-ray crystallographic analyses, NMR measurements, and molecular orbital (MO) calculations in relation to the large quantum yield of the coloring reaction of 2E upon the irradiation of UV light. The conformations of 1E and 2E obtained by X-ray crystallographic analyses are the photocyclization-possible ones (Eα), in which the distances of the bond-forming carbon atoms of 1E and 2E are essentially the same. NOESY of 1H NMR measurements of 1E and 2E showed that they take both the Eα and cyclization-impossible Eβ conformations in solution. Although MO calculations of 2E proved that the population of 2Eα is dominant when the entropy contributions of the rotation of substituents are considered, the large difference in the quantum yields was not fully elucidated. The difference may have come from a difference in the nature of the excited states of 1E and 2E, which is evidenced by the large difference in the molar absorption coefficient (1E: 6700, 2E: 4250 mol−1 dm3 cm−1 in toluene). The thermodynamic parameters of the enantiotopomerization process of 2E were determined by variable-temperature 1H NMR measurements. The mechanism of enantiotopomerization was specified by MO calculations.