gebhart/patrepeval huggingface dataset:
A structured language model (1997)

The paper presents a language model that develops syntatic structure and uses it to extract meaningful information from the word history, thus enabling the use of long distance dependencies. The model assigns probability to every joint sequence of words-binary-parse-structure with headword annotation. The model, its probabilistic parametrization, and a set of experiments meant to evaluate its predictive power are presented.
Diffuse mesothelin expression leads to worse prognosis through enhanced cellular proliferation in colorectal cancer (2020)

Mesothelin (MSLN) is a glycophosphatidylinositol (GPI)-linked cell surface protein that is highly expressed in several types of malignant tumor, including malignant pleural mesothelioma, ovarian cancer and pancreatic adenocarcinoma. Recently, a comprehensive immunohistochemical study using MN-1 monoclonal antibody identified a significant number of colorectal tumors in which MSLN was expressed. However, the clinicopathological profiles and survival of patients with MSLN-positive colorectal cancer have not been fully analyzed. In the current study, the expression of MSLN in 270 primary and 44 metastatic colorectal tumors was immunohistochemically analyzed to determine the clinical usefulness of MSLN immunohistochemistry and to identify potential candidates for future anti-MSLN therapy. <i>In vitro</i> experiments using colon cancer cell lines were performed to investigate the biological significance of MSLN expression in tumors. The results of univariate analyses identified a significant correlation between MSLN expression and females (P=0.0042). Furthermore, an inverse correlation between MSLN expression and solid/sheet-like proliferation (P=0.014) was also revealed. Additionally, overall survival was significantly shorter in patients with diffuse luminal/membranous expression of MSLN (P=0.018). Multivariable Cox hazards regression analysis revealed diffuse MSLN expression (hazard ratio, 2.26; 95% confidence interval, 1.04-4.91; P=0.039) as a potential risk factor. When comparing primary CRCs and the metastasis of each, a weakly positive correlation was identified for MSLN positivity (% positive cells; R=0.484; P<0.0001). The <i>in vitro</i> experiments revealed a positive role for MSLN in colon cancer cell proliferation. Thus, MSLN immunohistochemistry may be useful in the prognostication of patients with CRC. The results demonstrated that significant numbers of patients with MSLN-positive CRC exhibiting metastasis could be targeted by anti-MSLN therapies.
Systems approaches to design of targeted therapeutic delivery (2015)

Targeted drug delivery aims to improve therapeutic effects and enable mechanisms that are not feasible for untargeted agents (e.g., due to impermeable biological barriers). To achieve targeting, a drug or its carrier should possess properties providing specific accumulation from circulation at the desired site. There are several examples of systems-inspired approaches that have been applied to achieve this goal. First, proteomics analysis of plasma membrane fraction of the vascular endothelium has identified a series of target molecules and their ligands (e.g., antibodies) that deliver conjugated cargoes to well-defined vascular cells and subcellular compartments. Second, selection of ligands binding to cells of interest using phage display libraries in vitro and in vivo has provided peptides and polypeptides that bind to normal and pathologically altered cells. Finally, large-scale high-throughput combinatorial synthesis and selection of lipid- and polymer-based nanocarriers varying their chemical components has yielded a series of carriers accumulating in diverse organs and delivering RNA interference agents to diverse cells. Together, these approaches offer a basis for systems-based design and selection of targets, targeting molecules, and targeting vehicles. Current studies focus on expanding the arsenal of these and alternative targeting strategies, devising drug delivery systems capitalizing on these strategies and evaluation of their benefit/risk ratio in adequate animal models of human diseases. These efforts, combined with better understanding of mechanisms and unintended consequences of these targeted interventions, need to be ultimately translated into industrial development and the clinical domain.
Applications for Solid Propellant Cool Gas Generator Technology (2004)

In 2002 and 2003, Bradford Engineering B.V. conducted, in corporation with the Dutch research institute TNO Prins Maurits Laboratory (PML) a SME study for ESA-ESTEC for the identification of spaceflight applications and on-ground demonstration of Solid Propellant Cool Gas Generator (SPCGG) technology. This innovative technology has been developed by TNO-PML while Bradford Engineering also brought in its experience in spaceflight hardware development and manufacturing. The Solid Propellant Cool Gas Generator (SPCGG) technology allows for pure gas generation at ambient temperatures, as opposed to conventional solid propellant gas generators. This makes the SPCGG technology interesting for a wide range of terrestrial spaceflight applications. During the first part of the study, a variety of potential applications have been identified and three applications were selected for a more detailed quantitative study. In the third phase a ground demonstration was performed successfully for a cold gas propulsion system application. During the actual demonstration test, 10 cool gas generators were mounted and all operated successfully in sequence, demonstrating good repeatability of the produced amount of gas and pressure.
Robust Recognition of Simultaneous Speech by a Mobile Robot (2007)

This paper describes a system that gives a mobile robot the ability to perform automatic speech recognition with simultaneous speakers. A microphone array is used along with a real-time implementation of geometric source separation (GSS) and a postfilter that gives a further reduction of interference from other sources. The postfllter is also used to estimate the reliability of spectral features and compute a missing feature mask. The mask is used in a missing feature theory-based speech recognition system to recognize the speech from simultaneous Japanese speakers in the context of a humanoid robot. Recognition rates are presented for three simultaneous speakers located at 2 m from the robot. The system was evaluated on a 200-word vocabulary at different azimuths between sources, ranging from 10deg to 90deg. Compared to the use of the microphone array source separation alone, we demonstrate an average reduction in relative recognition error rate of 24% with the postfllter and of 42% when the missing features approach is combined with the postfllter. We demonstrate the effectiveness of our multisource microphone array postfilter and the improvement it provides when used in conjunction with the missing features theory.
Multi-detector receiver for laser ultrasonic measurement on the run (2011)

Laser-based ultrasonic (LBU) is now becoming a more mature technology, making the transition from research laboratory equipment to an industrial on-line measurement system. The non-contact and remote capability of LBU is an undeniable advantage for high-speed inspection. As LBU competes with other inspection technologies for on-line integration, LBU must retain its performance advantages despite operating in a far from ideal environment. In this paper, we review recent developments in a receiver based on multi-detector elements, which was specifically developed to meet the demanding needs of industrial inspections. We show that by integrating detector arrays into a classic interferometer design, we can transform a high sensitivity but delicate laboratory interferometer into a rugged system capable of enduring tough industrial environment.
e-Ireland: Europe's New Internet Hub (2001)

By the end of 2001, the Internet will have created a single market of about 300 million computers worldwide. According to Forrester Research, in 2000 global ecommerce transactions equaled about $657 billion. Most analysts predict that this number will increase more than tenfold by the year 2004. Even though North America will account for most of those profits in 2004, contributing close to $3.5 trillion, the region’s dominance will fade as Western Europe and Asian-Pacific countries experience intensive growth in 2002. (Forrester) The amazing thing is that these astounding numbers are only conservative estimates.
Classification of Gilthead Sea Bream (Sparus aurata) from 1H NMR Lipid Profiling Combined with Principal Component and Linear Discriminant Analysis (2007)

The combination of (1)H NMR fingerprinting of lipids from gilthead sea bream (Sparus aurata) with nonsupervised and supervised multivariate analysis was applied to differentiate wild and farmed fish and to classify farmed specimen according to their areas of production belonging to the Mediterranean basin. Principal component analysis (PCA) applied on processed (1)H NMR profiles made a clear distinction between wild and farmed samples. Linear discriminant analysis (LDA) allowed classification of samples according to the geographic origin, as well as for the wild and farmed status using both PCA scores and NMR data as variables. Variable selection for LDA was achieved with forward selection (stepwise) with a predefined 5% error level. The methods allowed the classification of 100% of the samples according to their wild and farmed status and 85-97% to geographic origin. Probabilistic neural network (PNN) analyses provided complementary means for the successful discrimination among classes investigated.
Enantioselective Organocatalytic Aminomethylation of Aldehydes: A Role for Ionic Interactions and Efficient Access to β2‐Amino Acids. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Reference interval for basal calcitonin and calcitonin concentrations after pentagastrin infusion. (1988)

Journal Article Reference interval for basal calcitonin and calcitonin concentrations after pentagastrin infusion. Get access R W Yatscoff, R W Yatscoff Dept. of Clin. Chem., Health Sciences Centre, Winnipeg, Manitoba, Canada Search for other works by this author on: Oxford Academic Google Scholar W J Dube W J Dube Dept. of Clin. Chem., Health Sciences Centre, Winnipeg, Manitoba, Canada Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 34, Issue 9, 1 September 1988, Pages 1931–1932, https://doi.org/10.1093/clinchem/34.9.1931a Published: 01 September 1988
A new catalyst-embedded hierarchical air electrode for high-performance Li–O2 batteries (2013)

The Li–O2 battery holds great promise as an ultra-high-energy-density device. However, its limited rechargeability and low energy efficiency remain key barriers to its practical application. Herein, we demonstrate that the ideal electrode morphology design combined with effective catalyst decoration can enhance the rechargeability of the Li–O2 battery over 100 cycles with full discharge and charge. An aligned carbon structure with a hierarchical micro-nano-mesh ensures facile accessibility of reaction products and provides the optimal catalytic conditions for the Pt catalyst. The new electrode is highly reversible even at the extremely high current rate of 2 A g−1. Moreover, we observed clearly distinct morphologies of discharge products when the catalyst is used. The effect of catalysts on the cycle stability is discussed.
Study of gate oxide traps in HfO2/AlGaN/GaN metal-oxide-semiconductor high-electron-mobility transistors by use of ac transconductance method (2013)

We introduce an ac-transconductance method to profile the gate oxide traps in a HfO2 gated AlGaN/GaN Metal-Oxide-Semiconductor High-Electron-Mobility Transistors (MOS-HEMTs) that can exchange carriers with metal gates, which in turn causes changes in analog and pulsed channel currents. The method extracts energy and spacial distributions of the oxide and interface traps under the gate from the frequency dependence of ac transconductance. We demonstrate the method using MOS-HEMTs with gate oxides that were annealed at different temperatures.
252 Oral Salmonella challenge alters feed preference in nursery pigs (2016)

Common industry practice is to segregate sick pigs; however, the same diet is provided. Due to the higher nutrient demand of the activated immune system, we hypothesized pigs would choose diets differing in nutrient content during an immune challenge when given choices. This study examined pig feed preference changes in response to an oral Salmonella challenge. Pigs (n = 30; 6.9 ± 0.1 kg BW) had ad libitum access to water and a common antibiotic-free (AF) phase 1 diet that was provided in 4 feeders within each pen from d0 to 7 postweaning (pw). On d7 pw, pigs were provided 4 AF phase 2 diets differing in composition: 1) Control (CON); 2) High Fat (HF; 33.75Kcal/kg > CON; 3) Low Protein (LP; 1.22% < CON) and 4) Low Carbohydrate/High Protein (LCHP; 6.5% simple sugars < CON and 1.8% protein > CON). Pigs were provided the diets in 4 separate feeders within each pen, with order randomized within and between pens from d7 to 28 pw. On d 14 pw, pigs were separated into 2 treatments: 1) Salmonella (SAL; n = 24) were orally inoculated with 4.8 × 109 cfu/pig Salmonella Typhimurium; and 2) Negative control (NC; n = 6) were orally administered PBS. Pigs were weighed on d −1, 7, 14, 21, and 28 pw and feeders were weighed daily from d 7 to 28 pw. Before analysis, feed disappearance data was summed into 7-d intervals. Feed disappearance data were analyzed as a MANOVA using the GLM procedure in SAS; pen was the subject, treatment was a fixed effect, and significant weekly weight change was included as a covariate. There was a treatment × time interaction (P = 0.0003) for weight; SAL pigs weighed less than NC pigs at d21 (14.0 ± 0.3 vs. 16.4 ± 0.6 kg) and 28 pw (19.5 ± 0.3 vs. 22.3 ± 0.6 kg). There was a trend (P = 0.135) for an overall treatment × time effect. Specifically, SAL pigs consumed more LCHP diet than NC pigs during d 7 to 14 (P = 0.009; 1.4 ± 0.1 vs. 0.3 ± 0.2 kg) and d14 to 21 (P = 0.017; 1.3 ± 0.2 vs. 0.3 ± 0.3 kg); SAL pigs consumed less LP diet than NC pigs d 14 to 21 pw (P = 0.037; 0.8 ± 0.1 vs. 1.5 ± 0.3 kg); SAL pigs tended (P = 0.0815) to consume more CON diet than NC pigs during d21 to 28 pw (1.8 ± 0.2 vs. 0.9 ± 0.4 kg). These data suggest nursery pigs consumed more of a LCHP diet and less of a LP diet during a Salmonella challenge, and consumed more of a CON diet 7 to 14 d postchallenge compared to non-challenged pigs. Further research must be conducted to determine if these diet choices would enhance recovery and performance in pigs exposed to Salmonella.
The road to IMT-advanced communication systems: State-of-the- art and innovation areas addressed by the WINNER + project (2009)

Phases I and II of the WINNER project contributed to the development, integration, and assessment of new mobile network techniques from 2004 to 2007. Some of these techniques are now in the 3GPP LTE and IEEE 802.16 (WiMAX) standards, while others are under consideration for LTE-Advanced and 802.16m. The WINNER+ project continues this forwardlooking work for IMT-advanced technologies and their evolution, with a particular focus on 3GPP LTE-Advanced. This article provides an overview of the WINNER system concept and several of its key innovative components.
Diffusion of cesium ion in silicon dioxide films derived from sol-gel precursors (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiffusion of cesium ion in silicon dioxide films derived from sol-gel precursorsCarol L. Schutte and George M. WhitesidesCite this: Chem. Mater. 1990, 2, 5, 576–581Publication Date (Print):September 1, 1990Publication History Published online1 May 2002Published inissue 1 September 1990https://pubs.acs.org/doi/10.1021/cm00011a021https://doi.org/10.1021/cm00011a021research-articleACS PublicationsRequest reuse permissionsArticle Views97Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Joint interference and user association optimization in cellular wireless networks (2014)

In cellular wireless networks, user association refers to the problem of assigning mobile users to base station cells - a critical, but challenging, problem in many emerging small cell and heterogeneous networks. This paper considers a general class of utility maximization problems for joint optimization of mobile user associations and bandwidth and power allocations. The formulation can incorporate a large class of network topologies, interference models, SNR-to-rate mappings and network constraints. In addition, the model can applied in carrier aggregation scenarios where mobiles can be served by multiple cells simultaneously. While the problem is non-convex, our main contribution shows that the optimization admits a separable dual decomposition. This property enables fast computation of upper bounds on the utility as well as an efficient, distributed implementation for approximate local optimization via augmented Lagrangian techniques. Simulations are presented in heterogeneous networks with mixtures of macro and picocells. We demonstrate significant value of the proposed methods in scenarios with variable backhaul capacity in the femtocell links and in cases where the user density is sufficiently low that lightly-used cells can reduce power.
Lyophobized Ordered Mesoporous Silica Additives for Li-O2 Battery Cathode (2014)

The surface of an ordered mesoporous silica (OMS) was functionalized using 1H,1H,2H,2H-perfluorooctyltrimethoxysilane at 20â and 60â. It was shown that only elevated temperature allows lyophobic properties on the walls of OMS, eventually preventing pore flooding with nonaqueous electrolytes. The functionalized OMSs (OMS-F) were characterized with various techniques: wettability test, N2 sorption measurement, high-resolution transmission electron microscopy (HR-TEM). Cathodes of 10mg/cm2 loading were prepared with a commercial Pt/C catalyst and polyvinylidene fluoride (PVDF, 2.5 wt.%) binder using a typical doctor blade method on a commercial gas diffusion layer (GDL) in the presence or in the absence of OMS-F additives. Subsequent discharge-charge curves were taken in a 1M LiTFSI-TEGDME electrolyte at 60â in pure oxygen atmosphere. It was found that the discharge capacity was significantly affected by OMS-F: 5 wt.% of additive extended discharge capacity by a factor 1.5. On the other hand, a similar OMS material but synthesized at 20â did not show lyophobic properties and deteriorated cathode capacity. Keywords: Li-air battery, oxygen transport, lyophobic ordered mesoporous silica, perfluorosilane
Celecoxib and Curcumin Additively Inhibit the Growth of Colorectal Cancer in a Rat Model (2006)

In vivo, curcumin augments the growth inhibitory effect of celecoxib. This may be clinically important as this dose of celecoxib can be achieved in human serum following standard anti-inflammatory dosing of 100 mg.
Baseband Digital Predistortion (2015)

This chapter discusses the implementation of predistorters in the baseband. Key issues related to the application of digital predistortion technique such as power alignment, direct and indirect learning techniques, and open and closed loop architectures are covered. Also, the concept of power and bandwidth scalable digital predistorters is introduced.
GCL polyphase sequences with minimum alphabets (1994)

Generalised chirp-like (GCL) polyphase sequences have the property that they can be modulated by a string of arbitrary complex numbers of unit magnitude, retaining the ideal periodic autocorrelation function and optimum crosscorrelation function. In the Letter, the large subclass of GCL sequences is derived which incorporate all the known different classes of polyphase sequences with ideal periodic autocorrelation and with minimum alphabets, such as Milewski sequences and the generalised Frank sequences.
Formation of Morphotropic Phase Boundary in (Na0.5K0.5)NbO3–BaZrO3–(Bi0.5Li0.5)TiO3 Lead-Free Piezoelectric Ceramics (2013)

For the development of lead-free piezoelectric ceramics, which have a tetragonal–rhombohedral morphotropic phase boundary (MPB), 0.90(Na 0.5 K 0.5 )NbO 3 – x BaZrO 3 –(0.10 - x )(Bi 0.5 Li 0.5 )TiO 3 ceramics have been synthesized by the conventional solid state reaction method. A phase diagram was summarized from the X-ray diffraction pattern and the dielectric measurements. It is found that 0.90(Na 0.5 K 0.5 )NbO 3 – x BaZrO 3 –(0.10 - x )(Bi 0.5 Li 0.5 )TiO 3 ceramics have an MPB between x = 0.07 and 0.08. In the vicinity of the MPB, it was observed that the dielectric and piezoelectric properties were enhanced.
Anomalous output conductance in N-polar GaN-based MIS-HEMTs (2011)

We propose that the anomalous output conductance in N-polar GaN MIS-HEMTs was caused by ionization of donor-like traps from a net negative polarization interface. It is a low-frequency phenomenon that changes the V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> of the device with V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sub> , while no evidence of increased output conductance or related device performance degradation was found under RF conditions. Appropriate back-barrier designs are needed to mitigate the DC-G <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DS</sub> in N-polar GaN MIS-HEMTs.
Proceedings of the 2016 Childhood Arthritis and Rheumatology Research Alliance (CARRA) Scientific Meeting (2016)

Evolving data link juvenile idiopathic arthritis (JIA) to environmental factors and gut microbes, which may trigger the innate immune system through bacterial lipopolysaccharides. We hypothesized that children with new onset JIA have increased intestinal bacterial translocation and endotoxinemia. Methods 65 new onset, systemic treatment naive JIA patients (polyarticular JIA, n = 21, oligoarticular JIA, n = 29 and spondylarthropathies, n = 15) and 14 healthy controls participated in the study. We determined the plasma immunoglobulin reactivity against Escherichia coli lipopolysaccharide (LPS). We measured the levels of lipopolysaccharide binding protein (LBP), and alpha-1-acid glycoprotein (A1AGP), which are acute phase proteins related to intestinal bacterial translocation, and C-reactive protein (CRP). Assays were performed using commercial EIA kits (Hycult, R&D systems) or laboratory-prepared LPS.