gebhart/patrepeval huggingface dataset:
Long-Term Soy Protein Isolate Consumption Reduces Liver Steatosis Through Changes in Global Transcriptomics in Obese Zucker Rats (2020)

To determine how soy protein isolate (SPI) ameliorated liver steatosis in male obese Zucker rats, we conducted global transcriptomic expression (RNAseq) analysis on liver samples of male rats fed either the SPI or a control casein (CAS)-based diet (n = 8 per group) for 16 weeks. Liver transcriptomics were analyzed using an Ilumina HiSeq system with 2 × 100 base pair paired-end reads method. Bioinformatics was conducted using Ingenuity Pathway Analysis (IPA) software (Qiagen, CA) with <i>P</i> < 0.05 and 1.3-fold differential expression cutoff values. Regression analysis between RNAseq data and targeted mRNA expression analysis of 12 top differentially expressed genes (from the IPA program) using quantitative PCR (qPCR) revealed a significant regression analysis (<i>r</i> <sup>2</sup> = 0.69, <i>P</i> = 0.0008). In addition, all qPCR values had qualitatively similar direction of up- or down-regulation compared to the RNAseq transcriptomic data. Diseases and function analyses that were based on differentially expressed target molecules in the dataset predicted that lipid metabolism would be enhanced whereas inflammation was predicted to be inhibited in SPI-fed compared to CAS-fed rats at 16 weeks. Combining upstream regulator and regulator effects functions in IPA facilitates the prediction of upstream regulators (e.g., transcription regulators) that could play important roles in attenuating or promoting liver steatosis due to SPI or CAS diets. Upstream regulators that were predicted to be activated (from expression of down-stream targets) linked to increased conversion of lipid and transport of lipid in SPI-fed rats included hepatocyte nuclear factor 4 alpha (HNF4A) and aryl hydrocarbon receptor (AHR). Upstream regulators that were predicted to be activated in CAS-fed rats linked to activation of phagocytosis and neutrophil chemotaxis included colony stimulating factor 2 and tumor necrosis factor. The results provide clear indication that long-term SPI-fed rats exhibited diminished inflammatory response and increased lipid transport in liver compared to CAS-fed rats that likely would contribute to reduced liver steatosis in this obese Zucker rat model.
Supplementary Text from Genetic Alterations in the Tyrosine Kinase Transcriptome of Human Cancer Cell Lines (2023)

Supplementary Text from Genetic Alterations in the Tyrosine Kinase Transcriptome of Human Cancer Cell Lines
A Mobile Robot Driven by Miniature Onboard Motors for Cardiac Intervention (2018)

This paper describes the development and construction of a mobile robot driven by miniature ultrasonic piezoelectric motors for minimally invasive cardiac therapy. The robot design extends upon previous prototypes of HeartLander, a miniature mobile robot that moves in an inchworm-like fashion. Construction of the system included motor selection, body design, and development of the control system. The robotic design was developed as a proof of concept to demonstrate mobility on the cardiac surface. This paper presents the design of the robotic platform and preliminary testing results in vitro. The development of the robot allows for increased turning capability and higher traction during locomotion, and represents the first step in designing a wireless mobile robot for cardiac therapy
40-Gbit/s Optical Data Exchange Between WDM Channels Using Second-Order Nonlinearities in PPLN Waveguides (2009)

We demonstrate 40-Gbit/s optical data exchange between WDM channels based on second-order nonlinearities in a periodically-poled Lithium-niobate (PPLN) waveguide. Channel-selective data exchange of four WDM signals is shown, which introduces ~4 dB penalty.
Sheath Flow Interface (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Proteases from human immunodeficiency virus and avian myeloblastosis virus show distinct specificities in hydrolysis of multidomain protein substrates (1990)

The virally encoded proteases from human immunodeficiency virus (HIV) and avian myeloblastosis virus (AMV) have been compared relative to their ability to hydrolyze a variant of the three-domain Pseudomonas exotoxin, PE66. This exotoxin derivative, missing domain I and referred to as LysPE40, is made up of a 13-kilodalton NH2-terminal translocation domain II connected by a segment of 40 amino acids to enzyme domain III of the toxin, a 23-kilodalton ADP-ribosyltransferase. HIV protease hydrolyzes two peptide bonds in LysPE40, a Leu-Leu bond in the interdomain region and a Leu-Ala bond in a nonstructured region three residues in from the NH2-terminus. Neither of these sites is cleaved by the AMV enzyme; hydrolysis occurs, instead, at an Asp-Val bond in another part of the interdomain segment and at a Leu-Thr bond in the NH2-terminal region of domain II. Synthetic peptides corresponding to these cleavage sites are hydrolyzed by the individual proteases with the same specificity displayed toward the protein substrate. Peptide substrates for one protease are neither substrates nor competitive inhibitors for the other. A potent inhibitor of HIV type 1 protease was more than 3 orders of magnitude less active toward the AMV enzyme. These results suggest that although the crystallographic models of Rous sarcoma virus protease (an enzyme nearly identical to the AMV enzyme) and HIV type 1 protease show a high degree of similarity, there exist structural differences between these retroviral proteases that are clearly reflected by their kinetic properties.
Recent Reviews. 38 (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleRecent Reviews. 38Veronica M. Cornel and Dennis C. LiottaCite this: J. Org. Chem. 1995, 60, 20, 6642–6650Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://pubs.acs.org/doi/10.1021/jo00125a069https://doi.org/10.1021/jo00125a069research-articleACS PublicationsRequest reuse permissionsArticle Views307Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Comprar Molecular Imaging: Principles and Practice | Ralph Weissleder | 9781607950059 | Mcgraw-Hill Education (2009)

Tienda online donde Comprar Molecular Imaging: Principles and Practice al precio 169,43 € de Ralph Weissleder | Kimberly Jefferson | Vance Fowler | Gordon Archer | Kent Crossley, tienda de Libros de Medicina, Libros de Biologia - Biologia general
Proton Conduction in In 3+ -doped Tin Phosphateswith Various P/(Sn+In) Ratios (2006)

Many approaches have been proposed for the design of intermediate-temperature proton conductors. However, the proton conductivities reported so far were in the range of 10S cm, which is not sufficiently high to provide high fuel cell performance. We recently reported that an anhydrous proton conductor, 10 mol% In doped tin phosphate (Sn0.9In0.1P2O7), shows high proton conductivities > 10 S cm between 150 and 300C. The resulting fuel cell demonstrated a high power density of 264mW cm (electrolyte thickness = 0.35mm) and excellent tolerance toward 10% CO at 250C. Furthermore, an electrochemical NOx reduction reactor using this material as an electrolyte exhibited a high current efficiency of 5.81% for the reduction of NOx into N2. In this paper, we evaluated proton conduction in In-doped tin phosphates with various P/(Sn+In) ratios.
Detecting visually significant cataract using retinal photograph-based deep learning (2022)

Age-related cataracts are the leading cause of visual impairment among older adults. Many significant cases remain undiagnosed or neglected in communities, due to limited availability or accessibility to cataract screening. In the present study, we report the development and validation of a retinal photograph-based, deep-learning algorithm for automated detection of visually significant cataracts, using more than 25,000 images from population-based studies. In the internal test set, the area under the receiver operating characteristic curve (AUROC) was 96.6%. External testing performed across three studies showed AUROCs of 91.6-96.5%. In a separate test set of 186 eyes, we further compared the algorithm's performance with 4 ophthalmologists' evaluations. The algorithm performed comparably, if not being slightly more superior (sensitivity of 93.3% versus 51.7-96.6% by ophthalmologists and specificity of 99.0% versus 90.7-97.9% by ophthalmologists). Our findings show the potential of a retinal photograph-based screening tool for visually significant cataracts among older adults, providing more appropriate referrals to tertiary eye centers.
Cyplecksins Are Covalent Inhibitors of the Pleckstrin Homology Domain of Cytohesin (2013)

The covalent grip: A new class of 5-bromobarbiturates (Cyplecksins; see structure) act by a covalent mechanism to inhibit the biological function of the pleckstrin homology domain of cytohesins, small guanine nucleotide exchange factors for the Ras-like ARF-GTPases. In cells, Cyplecksins interfere with the phosphoinositol-dependent membrane recruitment of cytohesins. Cyplecksins may be useful in validating cytohesins as potential drug targets.
SICKLE CELL DISEASE: ROLE OF REACTIVE OXYGEN AND NITROGEN METABOLITES (2007)

1. Sickle cell disease (SCD) is an inherited disorder of haemoglobin synthesis that is associated with significant morbidity and mortality due to sequelae of episodic vaso-occlusive events: pain crises and multiorgan damage. The microvascular responses to the initiation, progression and resolution of vaso-occlusive events are consistent with an inflammatory phenotype as suggested by activation of multiple cell types, an oxidatively stressed environment and endothelial cell dysfunction. 2. Decreased anti-oxidant defences in SCD patients and mice are accompanied by activation of enzymatic (NADPH oxidase, xanthine oxidase) and non-enzymatic (sickle haemoglobin auto-oxidation) sources of reactive oxygen species. The resultant oxidative stress leads to dysfunction/activation of arteriolar and venular endothelial cells, resulting in impaired vasomotor function and blood cell-endothelial cell adhesion. 3. Changes in substrate and cofactor availability for endothelial cell nitric oxide synthase may underlie reactive oxygen- and nitrogen-induced events that contribute to SCD-induced vasculopathy. 4. The emerging role of reactive oxygen and nitrogen species in the pathogenesis of SCD provides a platform for the development of novel agents to treat this painful and lethal disease.
Supplementary Figures 1 - 5 from Targeting Activated Akt with GDC-0068, a Novel Selective Akt Inhibitor That Is Efficacious in Multiple Tumor Models (2023)

&lt;p&gt;PDF file - 954K, Supplemental Figures: Figure S1. Chemical structure of the Akt inhibitor GDC-0068. Figure S2. Effect of GDC-0068 on cell cycle and apoptotic response on PC-3 and MCF7-neo/HER2 cell lines. Figure S3. Western blot analysis of indicated proteins in isogenic MCF10A cells with and without PTEN knockout in the presence of 20 or 0.2 ng/ml EGF. Figure S4. Representative immunohistochemistry staining images of cleaved caspase-3 in TOV-21G.x1 tumors. Figure S5. Combination effects between GDC-0068 and chemotherapeutic agents in vitro.&lt;/p&gt;
Ultraviolet photoelectron spectra of coinage metal clusters (1992)

Ultraviolet photoelectron spectra (UPS) were recorded for mass-selected negative clusters of copper (1–411 atoms), silver (1–60 atoms), and gold (1–233 atoms), using photodetachment lasers at 6.4 and 7.9 eV photon energy. The results provide a direct estimate of the vertical electron affinity (EA) of these clusters and information on the evolution of the d bands of copper and gold as a function of cluster size. The large even/odd alternation of EA in small clusters of these metals in earlier work is found to largely disappear as the cluster size exceeds 40 atoms. The ellipsoidal shell model is shown to be consistent with the observed EA behavior of all three metals, the predicted spherical shell closing at cluster 58 being evident for silver and gold. The UPS data show a smooth evolution of the d band toward that of the bulk metal.
Direct Imaging of Spatially Varying Potential and Charge across Internal Interfaces in Solids (1995)

Transmission electron holography is utilized to study the electrostatic potential and associated space charge across grain boundaries in SrTi${\mathrm{O}}_{3}$. While pristine boundaries show only the effect of a reduction in density of atoms, doped boundaries indicate the presence of potential barriers and associated space charge due to accumulation of charged point defects. This Letter demonstrates the viability of electron holography as a bulk sensitive tool to directly image and quantify the magnitude, sign, and spatial extent of electrical potential and charge across internal interfaces in solids.
Measured Evaluation of PV-DG-Hybrid Power Solutions in Indian Japanese Industrial Park (2019)

The authors constructed a micro grid by interconnecting multiple power sources. Low cost cooperative operation method of PV and DG was developed. The proposed method was evaluated by time axis simulation. It is possible to stably supply electric power following various load fluctuations at the factory. Furthermore, the voltage and frequency quality was verified by acquisition of long term actual measurement data. The results of verifying the fuel consumption reduction amount are described. It is possible to minimize the installed capacity of storage batteries, reactive-power compensators, for frequency and voltage stabilization by introducing renewable energy.
Order Reduction for Large-Scale Finite Element Models: A Systems Perspective (2005)

Large-scale finite element models are routinely used in design and optimization for complex engineering systems. However, the high model order prevents efficient exploration of the design space. Many model reduction methods have been proposed in the literature on approximating the high-dimensional model with a lower-order model. These methods typically replace a fine-scale model with a coarser-scale model in schemes, such as coarse graining, macromodeling, domain decomposition, and homogenization. This paper takes a systems perspective by stating the model reduction objective in terms of the approximation of the mapping between specified input and output variables. Methods from linear systems theory, including balance truncation and optimal Hankel norm approximation, are reviewed and compared to the standard modal truncation. For high-order systems, computational load, numerical stability, and memory storage become key considerations. We discuss several computationally more attractive iterative schemes that generate the approximate Gramian matrices needed in the model reduction procedure. A numerical example is also included to illustrate the model reduction algorithms discussed in the paper. We envision that these systems-oriented model reduction methods complementing the existing methods to produce low-order models suitable for design, optimization, and control.
Wideband and very wideband thin structural tiles for airborne active antennas (2013)

In the future, the level of operational performances that will be required from the systems of airborne RF sensors will be more and more important. In addition, the available space on board for antennas will be increasingly critical, especially on future fighter aircrafts and Unmanned Air Systems (UAS). It is therefore mandatory to develop high performance and thin radiating structures, such as active phased arrays, which can be integrated within the structure of the aircraft. To reduce the number of apertures, they will have to be shared by multiple applications: so, very wideband multifunction antennas from low bands to high bands will be needed. This presentation will show present research conducted at TSA on low profile Tiles for these applications.
The angiogenic factor CCN1 promotes re-endothelialization of decellularized pulmonary heart valves in vivo (2008)

Aims: In contrast to tissue engineered (decellularized and re-seeded) pulmonary heart valves (PV), decellularized allogenic PV lack a monolayer of endothelial cells when implanted for three months orthotopically in the juvenile sheep model. Here, we investigated whether coating with CCN1, a pro-angiogenic factor, may enhance the re-endothelialization of decellularized PV.
IMPUTATION OF COUPLED TENSORS AND GRAPHS (2018)

Joint analysis of data from different sources can potentially improve one's ability to reveal latent structure in heterogeneous datasets. For instance, social network activities and user demographic information can be leveraged to improve recommendations. However, the incompleteness and heterogeneity of the data challenge joint factorization of multiple datasets. Aspiring to address these challenges, the coupled graph tensor factorization model accounts for side information available in the form of correlation matrices or graphs. Here, a novel ADMM-based approach is put forth to impute missing entries and unveil hidden structure in the data. The iterative solver enjoys closed-form updates that result in reduced computational complexity. Numerical tests with synthetic and real data corroborate the merits of the proposed method relative to competing alternatives.
Power performance of MBE-grown N-face high electron mobility transistors with AIN back barrier (2008)

In summary, an N-face HEMT with good DC and RF properties was demonstrated. The use of AlN for electron confinement eliminates alloy scattering and offers a strong back barrier to mitigate short channel effects for highly scaled submicron devices. N-face devices are therefore expected to deliver excellent power density and efficiency with low leakage at microwave and mm-wave frequencies.
2906 A Sleeve type ECF Micro Artificial Muscle (2007)

This paper describes a novel micro artificial muscle actuator using electro-conjugate fluid (ECF micro artificial muscle actuator). The ECF micro artificial muscle actuator is a new type of soft actuator using an attractive smart fluid or electro-conjugate fluid (ECF). The electro-conjugate fluid generates a powerful jet flow when subjected to high DC voltage. We use this electro-conjugate fluid to control an inner pressure of a silicone rubber tube covered with a fiber sleeve. As the inner pressure being increased, the tube contracts along its axis. This micro artificial muscle actuator does not need any pumps outside, and in addition, the actuator itself is flexible enough for "soft robot," which is recently one of the most important research topics in the field of robotics and mechatronics.
Photochemically Initiated Protein Splicing (1995)

More details on the mechanism of protein splicing were revealed from the substitution of O ‐(2‐nitrobenzyl)serine for the conserved Ser1082 at the upstream splice junction of the self‐splicing DNA polymerase of Thermococcus litoralis . Full length precursor protein was produced, which underwent protein splicing only upon photolysis.
Einfluss von Depressivität auf die krankheitsspezifische Lebensqualität bei Patienten mit chronischer Otitis media (2019)

Patienten mit chronischer Otitis media (COM) klagen über Otorrhoe und Schwerhörigkeit. Der langjährige Krankheitsverlauf mit oft mehrfachen Operationen schränkt die betroffenen Patienten in ihrer Lebensqualität ein. Der Einfluss der psychischen Gesundheit auf die krankheitsspezifische Lebensqualität unter Berücksichtigung der objektivierten Ohrsymptomatik ist bislang nicht untersucht.
10nm high performance mobile SoC design and technology co-developed for performance, power, and area scaling (2017)

The industry's first 10nm low power high performance mobile SoC has been successfully ramped in production. Thanks to a thorough design-technology co-development, 10nm SoC is 16% faster, 37% smaller, and 30% lower power than its 14nm predecessor. The latest SoC features a gigabit class modem and is set to advance AR/VR, AI, machine learning, and computing. 10nm FinFet technology scaling challenges such as sharply increased wiring resistance and variation and strong layout stress effects are discussed to illustrate design and technology co-development from technology definition to product ramp stage is imperative to realize scaling entitlements.
Integrated photonic structures for efficient, massively-parallel collection of directional single-molecule fluorescence (2012)

A conical micromirror is shown to increase the signal from fluorescent molecules within a collocated subwavelength metal aperture by 5×. Large-scale integration (75,000 miromirrors/aperture pairs) is demonstrated.
A Combined‐Formulation Tablet of Lamivudine/Nevirapine/Stavudine: Bioequivalence Compared With Concurrent Administration of Lamivudine, Nevirapine, and Stavudine in Healthy Indian Subjects (2005)

Generic fixed-dose combinations of antiretrovirals are frequently prescribed for the treatment of human immunodeficiency virus infection. A randomized, 2-way study was conducted in 24 fasting, healthy, Indian male subjects to assess bioequivalence between a single combination tablet containing lamivudine, stavudine, and nevirapine (treatment A) with respect to separate marketed tablets administered simultaneously (treatment B). Each subject received treatments A and B separated by 19 days of a drug-free washout period. Plasma concentrations of antiretrovirals, determined by a validated liquid chromatography/tandem mass spectrometry assay, were used to assess pharmacokinetic parameters such as maximum observed plasma concentration and area under the plasma concentration curve. Pharmacokinetic parameters were comparable for either treatment. As geometric mean ratios (% treatment A/treatment B) of log-transformed parameters of area under the plasma concentration curve and plasma concentration, as well as their resultant 90% confidence intervals, were within 80% to 125% and 75% to 133%, respectively, 2 treatments were considered bioequivalent in the extent and rate of absorption. Both treatments exhibited similar tolerability under fasting conditions.