gebhart/patrepeval huggingface dataset:
Role of endothelial dysfunction, disturbance of haemostatic reactions in pathogenesis of acute exacerbation of chronic obstructive pulmonary disease (AE COPD) (2011)

Purpose: It is to research interrelations of endothelial dysfunction, system inflammatory and haemostatic reactions at patients with AE COPD. Materials and methods: In open prospective clinical investigation 111 patients with 2 or 3 positive criteria Anthonisen et al. (1987) were included. Men were 91 people (82%), women - 20 people (18%). The smoking index was 37,5±2,06 pack-years. Patients with AE COPD divided on two subgroups: 1st - patients without bronchoectasia, 2nd - patients with bronchoectasia. All patients received therapy by system glucocorticoids. The control group included 35 healthy non-smoking people with middle age 25,9±1,36 years, from them 27 (77,1%) men and 8 (22,9%) women. It was accomplished immuneenzyme definition of CRP, endotelin-1, D-dimers and homocystein maintenance in blood before treatment. Results: Direct correlation communication between indexes CRP and endotelin-1 (r=0,80, p&lt;0,001), indexes CRP and D-dimers (r=0,65, p&lt;0,01) in the AE COPD was observed. Dynamics of indexes of endothelial dysfunction and thrombogenic risk at patients with various phenotypes AE COPD are in table 1. Table 1 Indicators Control group Patients subgroup 1 Patients subgroup 2 before treating after treating before treating after treating CRP (mg/l) 3.3±0.14 6.5±1.97 4.1±1.16 13.3±3.32* 7.0±1.29* ET-1 (fmol/ml) 0.3±0.04 1.8±0.55* 1.2±0.38* 2.3±1.08 1.4±0.92 D-dimer (mg/l) 0.1±0.01 1.4±0.34* 0.6±0.12* 1.6±0.45* 1.0±0.26* *Patients subgroup vs. control group p&lt;0,05. Conclusion: At patients with AE COPD it is increased levels of D-dimers, which indicates that specifies on thrombogenic and thromboembolic risks.
Plasmonic gain in long-range surface plasmon polariton waveguides bounded symmetrically by dye-doped polymer (2015)

The plasmonic gain of a top-pumped active symmetric metal slab waveguide is investigated theoretically and experimentally. The structure consists of a thin Ag film cladded above and below by gain media (IR140-doped poly (methyl methacrylate)), and operating with long-range surface plasmon polaritons (LRSPPs) at near-infrared wavelengths. We consider the spatial distribution of the pump intensity and the position dependence of the dipole lifetime within the claddings when computing the LRSPP gain. We find that the bottom cladding provides significant gain to the LRSPP, despite the low pump transmittance through the Ag film, as long as the pump intensity is strong enough to saturate the gain material (∼4 MW/cm2). In this situation, the LRSPP gain is doubled compared to the case where the top cladding only is active. The LRSPP gain was measured in a fabricated structure using the variable stripe length method, yielding gmod = 16.7 cm−1 at a pump intensity of ∼4 MW/cm2. The measured LRSPP gain agrees very well with the computed value, implying that the bottom cladding provides significant gain to the mode. Active plasmonic devices based on the symmetric dielectric-metal-dielectric structure can be significantly more efficient by using gain layers as both the top and bottom claddings.
ACC/AHA 2005 guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): executive summary (2019)

These guidelines address the diagnosis and management of atherosclerotic, aneurysmal, and thromboembolic peripheral arterial diseases (PADs). The clinical manifestations of PAD are a major cause of acute and chronic illness, are associated with decrements in functional capacity and quality of life, cause limb amputation, and increase the risk of death. Whereas the term “peripheral arterial disease” encompasses a large series of disorders that affect arterial beds exclusive of the coronary arteries, this writing committee chose to limit the scope of the work of this document to include the disorders of the abdominal aorta, renal and mesenteric arteries, and lower extremity arteries. The purposes of the full guidelines are to (a) aid in the recognition, diagnosis, and treatment of PAD of the aorta and lower extremities, addressing its prevalence, impact on quality of life, cardiovascular ischemic risk, and risk of critical limb ischemia (CLI); (b) aid in the recognition, diagnosis, and treatment of renal and visceral arterial diseases; and (c) improve the detection and treatment of abdominal and branch artery aneurysms. Clinical management guidelines for other arterial beds (e.g., the thoracic aorta, carotid and vertebral arteries, and upper-extremity arteries) have been excluded from the current guidelines to focus on the infradiaphragmatic arterial system and in recognition of the robust evidence base that exists for the aortic, visceral, and lower extremity arteries.
Electrochemical genosensor based on gold nanostars for the detection of Escherichia coli O157:H7 DNA (2022)

<i>Escherichia coli</i> O157:H7 (<i>E. coli</i> O157:H7) is an enterohemorrhagic <i>E. coli</i> (EHEC), which has been issued as a major threat to public health worldwide due to fatal contamination of water and food. Thus, its rapid and accurate detection has tremendous importance in environmental monitoring and human health. In this regard, we report a simple and sensitive electrochemical DNA biosensor by targeting Z3276 as a genetic marker in river water. The surface of the designed gold electrode was functionalized with gold nanostars and an aminated specific sensing probe of <i>E. coli</i> O157:H7 to fabricate the genosensor. Cyclic voltammetry (CV) and square wave voltammetry (SWV) techniques were applied for electrochemical characterization and detection. The synthesized gold nanostars were characterized using different characterization techniques. The fabricated DNA-based sensor exhibited a high selective ability for one, two, and three-base mismatched sequences. Regeneration, stability, selectivity, and kinetics of the bioassay were investigated. Under optimal conditions, the fabricated genosensor exhibited a linear response range of 10<sup>-5</sup> to 10<sup>-17</sup> μM in the standard sample and 7.3 to 1 × 10<sup>-17</sup> μM in water samples with a low limit of quantification of 0.01 zM in water samples. The detection strategy based on silver plated gold nanostars and DNA hybridization improved the sensitivity and specificity of the assay for <i>E. coli</i> O157:H7 detection in real water samples without filtration. The detection assay has the advantages of high selectivity, sensitivity, low amounts of reagents, short analysis time, commercialization, and potential application for the determination of other pathogenic bacteria.
Efficiency and Power Factor Improvement of Induction Motor Using Single-Phase Back Rectifier (2002)

일반적으로 유도 전동기 가변속 운전할 때 인버터의 스위칭 작용으로 많은 고조파가 포함되어 전동기의 고조파 손실, 토크 맥동, 전자기적 소음 및 진동 등을 초래하게 된다. 이와 같은 문제점을 해결하기 위하여 본 논문에서는 부분공진 벅 컨버터와 3상 전압형 SPWM 인버터 회로를 유도전동기 운전시스템에 적용하였다. 제안한 회로의 입력전류를 거의 단위 역률로 정현파화하기 위해 동작 조건을 다양하게 변화시켰으며 커패시터는 보조다이오드와 전력스위칭에 적절히 배열하여 전원측으로 전압을 회생시켜 공급하였다. 그리고 전압반전기능을 부가하는 것에 의해 전원전압 극성 반전시 입력전류의 변형 최소화함으로서 역률 및 효율이 개선시켰다. 또한 출력 필터를 이용하여 출력선간전압의 고조파 성분을 감소하였으며, 상태공간 해석을 도입하여 정류기의 동작을 예측하였다. 이러한 모든 사항은 시뮬레이션과 실험을 통하여 그 타당성을 확인하였다.
Supplementary Figure S3 from A Dendritic Cell Vaccine Pulsed with Autologous Hypochlorous Acid-Oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity: From Bench to Bedside (2023)

&lt;p&gt;Supplementary Figure S3 - PDF file 128K, OCDC manufacturing process. Elutriated monocytes were obtained from subjects after leukapheresis and cultured in cell factories as described in Materials and Methods. HOCl-oxidized autologous tumor lysate was pulsed onto DCs for 16 to 20 hours, followed by activation and maturation with LPS and IFN-gamma for 6 to 8 hours. On day 5 of culture, matured lysate-pulsed DCs were harvested and cryopreserved until required&lt;/p&gt;
Entropy-Driven Crystallization behavior in DNA-Mediated Nanoparticle Assembly* (2020)

880Herein, we report an example of entropy-driven crystallization behavior in DNA-nanoparticle superlattice assembly, marking a divergence from the well-established enthalpic driving force of maximizing nearest-neighbor hybridization connections. Such behavior is manifested in the observation of a non-close-packed, body-centered cubic (bcc) superlattice when using a system with self-complementary DNA linkers that would be predicted to form a close-packed, face-centered cubic (fcc) structure based solely on enthalpic considerations and previous design rules for DNA-linked particle assembly. Notably, this unexpected phase behavior is only observed when employing long DNA linkers with unpaired “flexor” bases positioned along the length of the DNA linker that increase the number of microstates available to the DNA ligands. A range of design conditions are tested showing sudden onsets of this behavior, and these experiments are coupled with coarse-grained molecular dynamics simulations to show that this entropy-driven crystallization behavior is due to the accessibility of additional microstates afforded by using long and flexible linkers.
Pure Topological Mapping in Mobile Robotics (2010)

In this paper, we investigate a pure form of the topological mapping problem in mobile robotics. We consider the mapping ability of a robot navigating a graph-like world in which it is able to assign a relative ordering to the edges, leaving a vertex with reference to the edge by which it arrived but is unable to associate a unique label with any vertex or edge. Our work extends and builds upon earlier approaches in this problem domain, which are based on construction of exploration tree of plausible world models. The main contributions of the paper are improved exploration strategies that reduce model ambiguity, a new method of search through consistent models in the exploration tree that maintains a bounded set of likely hypotheses based on the principle of Occam's Razor, the incorporation of arbitrary feature vectors into the problem formulation, and an investigation of various aspects of this problem through numerical simulations.
2311 Development of Partial-contact Slider for Ultra-low Flying (2005)

An isolated pad type slider and a narrow trailing edge type slider was designed and fabricated for a partial-contact head-disk interface. Evaluation results showed that friction reduction is the key point for a partial-contact interface. A smaller isolated pad slider exhibited a smaller off-track vibration and less aggressive disk lubricant depletion. Moreover, drive tests of a narrower trailing edge slider showed that narrower trailing edge has the advantage of easier transition from contact to flying.
Damage Tolerance Improvement of Ti-6-4 Fan Blades With Low Plasticity Burnishing (2002)

Low plasticity burnishing (LPB) has been demonstrated to increase the damage tolerance of Ti6Al-4V fan blades by an order of magnitude. First stage Ti-6Al-4V fan blades were LPB processed using a conventional 4-axis CNC machine tool. LPB dramatically improved surface finish with negligible blade distortion and produced compressive residual stresses of -690 MPa (-100 ksi) through the entire thickness of the blade leading edge. Fatigue testing demonstrated that the deep compression of LPB provided a 3X improvement in HCF endurance limit, complete tolerance of FOD up to 1.3 mm (0.050 in.) deep, and an order of magnitude improvement in fatigue life. Damage tolerance for the TI-6AL-4V fan blade was improved by an order of magnitude.
The structure of sirohydrochlorin I, a dimethylisobacteriochlorin derived from uroporphyrinogen I (1989)

Purified S-adenosyl-L-methionine: uroporphyrinogen (uro'gen) III methyl transferase (SUMT), the first methylase of the vitamin B12 pathway (from Pseudomonas denitrificans), synthesizes a type I isomer of sirohydrochlorin from uro'gen I (1).
Experience-dependent cortical processing of complex sounds by rats (2002)

Auditory cortex is thought to play a critical role in the processing of species-specific vocalizations and other acoustically complex sounds. Although evolutionary processes strongly constrain cortical sensitivities to sound, cortical processing is not fixed by biology, but rather is shaped by the auditory experiences of each individual. Auditory cortical neurons in adult rats respond selectively to spectrotemporal features of complex sounds. These selective responses are predictive of rats’ behaviorally measured perceptual sensitivities. With extensive training, the abilities of rats to discriminate frequency-modulated sounds improve. Recordings from cortical neurons in trained rats show increased sensitivities to features of the sounds used in training. These results demonstrate that discrimination training with biologically irrelevant complex sounds can change how cortical neurons process those sounds. Changes in cortical processing of complex sounds can also be induced by controlling activity in neuromodulatory neurons while a rat experiences the sounds. Pairing the presentation of complex sounds with electrical stimulation of basal forebrain neurons radically changes cortical sensitivities to spectrotemporal features of those sounds. These data suggest that auditory cortical representations of acoustic events can be flexibly adjusted throughout the lifespan of an individual rate. Presumably, similar or greater flexibility exists in animals with more sophisticated auditory systems.
PCP Thermal Course: Photometrics / Measurements. (2018)

Abstract not provided.
Structural and thermal modeling of az-axis rate integrating gyroscope (2003)

This paper presents results of structural and thermal modeling of a z-axis rate integrating gyroscope. A strain energy method is used to obtain a structural model of the device, which is verified using finite element analysis. Based on a parametric analysis, an appropriate micromachining technology suitable for the fabrication of the gyroscope is identified. A sensitivity study shows that the operational modes of the proposed gyroscope remain matched under thermal and stress fluctuations, whereas a device with a commonly used H-type suspension shows a 31% frequency mismatch under thermal loading of 23.67 °C or 9 MPa of compressive stress.
D9.3 - State of the Art Telemetric Implantable Sensors and Their Encapsulation (2013)

MEMS sensor have the potential to revolutionize medical implants. Their advantages are a small form factor, low power consumption and the ability to operate by telemetry. While some MEMS sensors, for example to measure pressure, have reached a high level of maturity, their encapsulation for long term implants remains problematic. Here, a novel encapsulation a technique is presented that combines flexibility with long term stability. It relies on a two layer approach: the outer thicker layer consists of a polymer, while the inner layer consists of a stack of thin layers which is long term stable and water vapor impenetrable. Furthermore, the discussed pressure sensor can be operated wirelessly, therefore no battery is required. The operation is described, and some initial measurement data on animal trials are presented.
Optimal transmitter eigen-beamforming and space-time block coding based on channel correlations (2003)

Optimal transmitter designs obeying the water-filling principle are well-documented, and widely applied, when the propagation channel is deterministically known and regularly updated at the transmitter. Because channel state information (CSI) may be costly or impossible to acquire in rapidly varying wireless environments, we develop in this paper statistical water-filling approaches for stationary random fading channels. These approaches require only knowledge of the channel correlations that do not necessitate frequent updates, and can be easily acquired. Applied to a multiple transmit-antenna paradigm, our optimal transmitter design turns out to be an eigen-beamformer with multiple beams pointing to orthogonal directions along the eigenvectors of the channel's correlation matrix, and with proper power loading across the beams. The optimality pertains to minimizing a tight bound on the symbol error rate. The resulting loaded eigen-beamforming outperforms not only the equal-power allocation across all antennas, but also the conventional beamformer that transmits the available power along the strongest direction. Coupled with orthogonal space-time block codes, two-dimensional (2-D) eigen-beamforming emerges as a more attractive choice than conventional one-dimensional (1-D) beamforming with uniformly better performance, without rate reduction, and without complexity increase.
Aptamer Nanoflares for Molecular Detection in Living Cells* (2020)

We demonstrate a composite nanomaterial, termed an aptamer nanoflare, that can directly quantify an intracellular analyte in a living cell. Aptamer nanoflares consist of a gold nanoparticle core functionalized with a dense monolayer of nucleic acid aptamers with a high affinity for adenosine triphosphate (ATP). The probes bind selectively to target molecules and release fluorescent reporters 1728which indicate the presence of the analyte. Additionally, these nanoconjugates are readily taken up by cells where their signal intensity can be used to quantify intracellular analyte concentration. These nanoconjugates are a promising approach for the intracellular quantification of other small molecules or proteins, or as agents that use to elicit a in
An updated applied formulation for the Goubau transmission line (2019)

The Goubau line is a unique transmission line that consists of only a single conductor. Its unique properties make it a solid candidate for low-loss RF propagation and wireless power transfer applications. However, the applied theory of this line that has been established thus far is missing key details of the line's characteristics. Namely, no discussion has been made on the Goubau line's ohmic current distribution or its effective characteristic impedance that would be used in RF/microwave circuit analysis scenarios. Furthermore, the method previously used to solve the waveguide mode is laborious and obsolete when considering current computational methods. In this work, an updated, efficient mode solution process for the Goubau line will be presented, and the current, loss, and characteristic impedance of the line will be discussed. Additionally, all other waveguide parameters such as wave velocity, guide wavelength, propagation constant, etc. will be investigated.
Passive DNA demethylation preferentially up-regulates pluripotency-related genes and facilitates the generation of induced pluripotent stem cells (2017)

A high proliferation rate has been observed to facilitate somatic cell reprogramming, but the pathways that connect proliferation and reprogramming have not been reported. DNA methyltransferase 1 (DNMT1) methylates hemimethylated CpG sites produced during S phase and maintains stable inheritance of DNA methylation. Impairing this process results in passive DNA demethylation. In this study, we show that the cell proliferation rate positively correlated with the expression of <i>Dnmt1</i> in G<sub>1</sub> phase. In addition, as determined by whole-genome bisulfate sequencing and high-performance liquid chromatography, global DNA methylation of mouse embryonic fibroblasts was significantly higher in G<sub>1</sub> phase than in G<sub>2</sub>/M phase. Thus, we suspected that high cellular proliferation requires more <i>Dnmt1</i> expression in G<sub>1</sub> phase to prevent passive DNA demethylation. The methylation differences of individual CpG sites between G<sub>1</sub> and G<sub>2</sub>/M phase were related to the methylation status and the positions of their surrounding CpG sites. In addition, larger methylation differences were observed on the promoters of pluripotency-related genes; for example, <i>Oct4</i>, <i>Nanog</i>, <i>Sox2</i>, <i>Esrrb</i>, <i>Cdh1</i>, and <i>Epcam</i> When such methylation differences or passive DNA demethylation accumulated with <i>Dnmt1</i> suppression and proliferation acceleration, DNA methylation on pluripotency-related genes was decreased, and their expression was up-regulated, which subsequently promoted pluripotency and mesenchymal-epithelial transition, a necessary step for reprogramming. We infer that high cellular proliferation rates promote generation of induced pluripotent stem cells at least partially by inducing passive DNA demethylation and up-regulating pluripotency-related genes. Therefore, these results uncover a connection between cell reprogramming and DNA methylation.
Transcriptomic signatures of exacerbated progression in leptospirosis subclinical chronic kidney disease with secondary nephrotoxic injury (2021)

High-incidence regions of leptospirosis caused by <i>Leptospira</i> spp. coincide with chronic kidney disease. This study investigated whether asymptomatic leptospirosis is an emerging culprit that predisposes to progressive chronic kidney disease when superimposed on secondary nephrotoxic injury. Kidney histology/function and whole transcriptomic profiles were evaluated for <i>Leptospira</i>-infected C57/BL6 mice with adenine-induced kidney injury. The extent of tubulointerstitial kidney lesions and expression of inflammation/fibrosis genes in infected mice with low-dose (0.1%) adenine, particularly in high-dose (0.2%) adenine-fed superimposed on <i>Leptospira</i>-infected mice, were significantly increased compared with mice following infection or adenine diet alone, and the findings are consistent with renal transcriptome analysis. Pathway enrichment findings showed that integrin-β- and fibronectin-encoding genes had distinct expression within the integrin-linked kinase-signaling pathway, which were upregulated in 0.2% adenine-fed <i>Leptospira</i>-infected mice but not in 0.2% adenine-fed mice, indicating that background subclinical <i>Leptospiral</i> infection indeed enhanced subsequent secondary nephrotoxic kidney injury and potential pathogenic molecules associated with secondary nephrotoxic leptospirosis. Comparative analysis of gene expression patterns with unilateral ureteric obstruction-induced mouse renal fibrosis and patients with chronic kidney disease showed that differentially expressed orthologous genes such as hemoglobin-α<sub>2</sub>, PDZ-binding kinase, and DNA topoisomerase II-α were identified in infected mice fed with low-dose and high-dose adenine, respectively, revealing differentially expressed signatures identical to those found in the datasets and may serve as markers of aggravated kidney progression. This study indicates that background subclinical leptospirosis, when subjected to various degrees of subsequent secondary nephrotoxic injury, may predispose to exacerbated fibrosis, mimicking the pathophysiological process of progressive chronic kidney disease.<b>NEW & NOTEWORTHY</b><i>Leptospira</i>-infected mice followed by secondary nephrotoxic injury exacerbated immune/inflammatory responses and renal fibrosis. Comparison with the murine model revealed candidates involved in the progression of renal fibrosis in chronic kidney disease (CKD). Comparative transcriptome study suggests that secondary nephrotoxic injury in <i>Leptospira</i>-infected mice recapitulates the gene expression signatures found in CKD patients. This study indicates that secondary nephrotoxic injury may exacerbate CKD in chronic <i>Leptospira</i> infection implicating in the progression of CKD of unknown etiology.