gebhart/patrepeval huggingface dataset:
Diminished microRNA-29b level is associated with BRD4-mediated activation of oncogenes in cutaneous T-cell lymphoma (2017)

MicroRNA (miRNA) dysregulation is a hallmark of cutaneous T-cell lymphoma (CTCL), an often-fatal malignancy of skin-homing CD4<sup>+</sup> T cells for which there are few effective therapies. The role of microRNAs (miRs) in controlling epigenetic modifier-dependent transcriptional regulation in CTCL is unknown. In this study, we characterize a novel miR dysregulation that contributes to overexpression of the epigenetic reader bromodomain-containing protein 4 (BRD4). We used patient CD4<sup>+</sup> T cells to show diminished levels of miR-29b compared with healthy donor cells. Patient cells and miR-29b<sup>-/-</sup> mouse cells revealed an inverse relationship between miR-29b and BRD4, the latter of which is overexpressed in these cells. Chromatin immunoprecipitation and sequencing analysis revealed increased genome-wide BRD4 occupancy at promoter and enhancer regions in CD4<sup>+</sup> T cells from CTCL patients. The cumulative result of BRD4 binding was increased expression of tumor-associated genes such as <i>NOTCH1</i> and <i>RBPJ</i>, as well as the interleukin-15 (IL-15) receptor complex, the latter enhancing IL-15 autocrine signaling. Furthermore, we confirm the in vivo relevance of this pathway in our IL-15 transgenic mouse model of CTCL by showing that interference with BRD4-mediated pathogenesis, either by restoring miR-29b levels via bortezomib treatment or by directly inhibiting BRD4 binding via JQ1 treatment, prevents progression of CTCL. We describe a novel oncogenic pathway featuring IL-15, miR-29b, and BRD4 in CTCL and suggest targeting of these components as a potentially effective therapy for CTCL patients.
Broadband photonic quantum interface based on a cavity-protected rare-earth ensemble (Conference Presentation) (2017)

Rare-earth ions doped in crystals are renowned for their excellent coherence properties and large inhomogeneous broadening, which make them ideal for quantum interfaces with broadband photons. These properties have made them one of the leading technologies in quantum optical memories and a promising candidate for optical-to-microwave conversion. To take advantage of the full bandwidth of the rare-earth ensemble, one must overcome the decoherence of a broadband collective excitation due to inhomogeneous broadening. To this end, techniques based on controllable rephasing, such as atomic frequency comb (AFC) or controlled reversible inhomogeneous broadening (CRIB) memories, have been developed with great success. Recently, an alternative method was proposed to suppress the decoherence of an inhomogeneous ensemble via strong coupling to a cavity, a phenomenon called cavity protection. This technique has been demonstrated in the microwave domain with an NV spin ensemble, but has not been demonstrated in the optical domain. Here, we demonstrate cavity protection in the optical domain at the single photon level using an ensemble of rare earths ions coupled to a nanophotonic resonator. The reduction in decoherence due to the cavity-protection effect enables transfer of ultrafast (~50 GHz) frequency qubits into the collective ion excitation and retrieval with 98.7% fidelity. Building on these results to transfer these excitations to long-lived spin states would enable broadband, on-demand quantum memories. Furthermore, this works compliments the work done coupling rare-earths to superconducting resonators in the microwave regime with potential for applications in optical-to-microwave transducers.
Modulation-transfer function measurement of SPRITE detectors: sine-wave response (1992)

A method is presented for measuring the modulation transfer function of signal processing in the element (SPRITE) detectors with a HgCdTe composition optimized for the 3-5-microm band. This method incorporates a 3.39-microm He-Ne laser to generate Young's fringes of varying spatial frequency, which are scanned across the detector elements. The results are consistent with theoretical models for these devices and indicate a limited resolution capability for SPRITE detectors used for the 3-5-microm band.
Total differential optical properties of polymer nanocomposite materials (2006)

The Maxwell-Garnett and Bruggeman effective medium models are extended to a total differential model to predict differential changes in the optical properties of polymer nanocomposites in response to external influences. A Mie scattering model was used to model the transmission properties of these materials.
ChemInform Abstract: 3‐Hydroxymuscarines from L‐Rhamnose. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Dynamic Intermittent Feedback Design for $H_{\infty}$ Containment Control on a Directed Graph (2019)

This article develops a novel distributed intermittent control framework with the ultimate goal of reducing the communication burden in containment control of multiagent systems communicating via a directed graph. Agents are assumed to be under disturbance and communicate on a directed graph. Both static and dynamic intermittent protocols are proposed. Intermittent H<sub>∞</sub> containment control design is considered to attenuate the effect of the disturbance and the game algebraic Riccati equation (GARE) is employed to design the coupling and feedback gains for both static and dynamic intermittent feedback. A novel scheme is then used to unify continuous, static, and dynamic intermittent containment protocols. Finally, simulation results verify the efficacy of the proposed approach.
Synthesis of Various Substituted Dibenzo[b,d]pyranones Including Amino Acid Derivatives by SRN1 Methodology (1993)

An easy preparation of the title compounds involving a S R N l ortho-arylation of phenolates by o - bromobenzonitrile followed by Si02-catalysed lactonisation is described.Activated o r not activated phenols are efficient.Access to benzonaphthopyranones is exemplified by the reactions with 2-naphtholate.Reactions with chiral phydroxyphenylamino acid derivatives are also reported.
[Congenital lactase deficiency--a more common disease than previously thought?]. (2009)

Congenital lactase deficiency belongs to the Finnish Disease Heritage and is a recessively inherited diarrheal disease of the newborn, in which the activity of the lactase enzyme of the epithelial cells of the small intestine is very low ever since the birth. For the newborn infant, ingestion of lactose causes symptoms so severe that breastfeeding is not possible. Untreated disease leads to dehydration that usually requires hospitalization. Congenital lactase deficiency is caused by mutations in the gene coding for the lactase enzyme (LCT). Seven mutations in a total of 43 patients have been found in Finland so far.
Supplementary Figure 8 from Genomic Alterations of Anaplastic Lymphoma Kinase May Sensitize Tumors to Anaplastic Lymphoma Kinase Inhibitors (2023)

Supplementary Figure 8 from Genomic Alterations of Anaplastic Lymphoma Kinase May Sensitize Tumors to Anaplastic Lymphoma Kinase Inhibitors
Molecular imaging of deep vein thrombosis using a new fibrin-targeted near-infrared fluorescence (NIRF) imaging strategy (2011)

4 Objectives The development of a near-infrared fluorescence (NIRF) fibrin-targeted sensor could enable highly sensitive in vivo optical imaging of thrombosis syndromes. Here we synthesize and validate a new fibrin-targeted peptide that enables multimodal NIRF imaging of murine deep vein thrombosis (DVT). Methods We synthesized a fibrin-targeted peptide conjugated to an NIR fluorochrome Cy7 (Cy7-YDEChyPClYGLCYIQ, ex/em 743/767nm). The NIRF agent is based on a fibrin peptide (EP-2104R) that has completed phase 2 clinical MRI trials. In vitro binding of the NIRF peptide to human plasma clots was assessed by fluorescence reflectance imaging (FRI) system (ex/em 740/790). Next, the fibrin-targeted NIRF agent was injected in vivo in a murine DVT model (topical ferric chloride applied to the femoral or jugular vein). Intravital fluorescence microscopy (IVFM) of femoral vessels was performed in mice with acute (2 hours old, n = 5) and sub-acute (72 hours old, n = 3) thrombi. Noninvasive fluorescence molecular tomography (FMT)-computed tomography (CT) was next performed in mice with sub-acute jugular vein DVT (n=2), followed by ex vivo imaging. Results In vitro clot-binding analyses showed a significantly higher NIRF clot target-to-background ratio (TBR) of fibrin-targeted peptide than free Cy7, and its binding was significantly blocked with a 100-fold excess of competitor peptide, indicating that the engineered NIRF peptide is fibrin specific. IVFM of femoral DVT also demonstrated a high TBR both in acute (mean TBR = 2.9 ± 0.3) and sub-acute (mean TBR = 3.9 ± 0.5) thrombi. Noninvasive FMT-CT demonstrated strong focal signal in the left jugular DVT compared with right sham-operated jugular vein. Conclusions The synthesized NIRF fibrin-targeted peptide avidly binds human clots and enables sensitive, fast multimodal optical imaging detection of acute and sub-acute DVT in vivo
Front Matter: Volume 6774 (2007)

This PDF file contains the front matter associated with SPIE Proceedings Volume 6774, including the Title Page, Copyright information, Table of Contents, Introduction (if any), and the Conference Committee listing.
Inductor and TSV Design of 20-V Boost Converter for Low Power 3D Solid State Drive with NAND Flash Memories (2010)

Two essential technologies for a 3D Solid State Drive (3D-SSD) with a boost converter are presented in this paper. The first topic is the spiral inductor design which determines the performance of the boost converter, and the second is the effect of TSV's on the boost converter. These techniques are very important in achieving a 3D-SSD with a boost converter. In the design of the inductor, the on-board inductor from 250nH to 320nH is the best design feature that meets all requirements, including high output voltage above 20V, fast rise time, low energy consumption, and area smaller than 25mm2. The use of a boost converter with the proposed inductor leads to a reduction of the energy consumption during the write operation of the proposed 1.8-V 3D-SSD by 68% compared with the conventional 3.3-V 3D-SSD with the charge pump. The feasibility of 3D-SSD's with Through Silicon Vias (TSV's) connections is also discussed. In order to maintain the advantages of the boost converter over the charge pump, the reduction of the parasitic resistance of TSV's is very important.
In vivo haematopoietic potential of human neural stem cells (2005)

The fetal sheep model was used to compare the in vivo haematopoietic potential of human neural stem cells (NSC) versus bone marrow (BM)-derived haematopoietic stem cells (HSC). To this end, sheep were transplanted with either 8 x 10(5) NSC (n = 11) or HSC, CD34(+)Lin(-) (n = 5), and subsequently analysed for haematopoietic chimaerism. While HSC-transplanted sheep displayed robust donor-derived haematopoiesis starting at less than 2 months post-transplant, NSC recipients exhibited haematopoietic engraftment at much later time points. Nevertheless, chimaerism persisted in both groups throughout the course of this study. Transplantation of secondary recipients with human CD45(+)/HLA-DR(+) cells from the BM of NSC primary recipients at 14 and 16 months post-transplant demonstrated that long-term engrafting HSC were present in these animals. At 6 months post-transplant, both NSC- and HSC-transplanted sheep were mobilised with granulocyte colony-stimulating factor. In contrast to HSC-transplanted animals, levels of human blood cells in peripheral blood of NSC-transplanted sheep remained low throughout mobilisation. Our results show that, although human NSC were able to give rise to multilineage haematopoiesis in our model, the levels, timing of blood cell production and the ability to respond to cytokine mobilisation were different, suggesting that human NSCs latent haematopoietic potential is inherently different from that of true HSC.
Merging bound states in the continuum by harnessing higher-order topological charges (2022)

Bound states in the continuum (BICs) can confine light with a theoretically infinite Q factor. However, in practical on-chip resonators, scattering loss caused by inevitable fabrication imperfection leads to finite Q factors due to the coupling of BICs with nearby radiative states. Merging multiple BICs can improve the robustness of BICs against fabrication imperfection by improving the Q factors of nearby states over a broad wavevector range. To date, the studies of merging BICs have been limited to fundamental BICs with topological charges ±1. Here we show the unique advantages of higher-order BICs (those with higher-order topological charges) in constructing merging BICs. Merging multiple BICs with a higher-order BIC can further improve the Q factors compared with those involving only fundamental BICs. In addition, higher-order BICs offer great flexibility in realizing steerable off-Γ merging BICs. A higher-order BIC at Γ can split into a few off-Γ fundamental BICs by reducing the system symmetry. The split BICs can then be tuned to merge with another BIC, e.g., an accidental BIC, at an off-Γ point. When the in-plane mirror symmetry is further broken, merging BICs become steerable in the reciprocal space. Merging BICs provide a paradigm to achieve robust ultrahigh-Q resonances, which are important in enhancing nonlinear and quantum effects and improving the performance of optoelectronic devices.
10kV SiC-based isolated DC-DC converter for medium voltage-connected Solid-State Transformers (2015)

Silicon-carbide semiconductor technology offers the possibility to synthesize power devices with unprecedented blocking voltage capabilities while achieving outstanding switching and conduction performances. Accordingly, this new semiconductor technology is especially interesting for Solid-State Transformer concepts and is utilized in this paper for designing a 25 kW/50 kHz prototype based on 10 kV SiC devices, featuring a 400V DC output. The focus is on the DC-DC converter stage while special attention is placed on the large step-down medium frequency transformer, whereby the impact of the rather high operating frequency and high number of turns with respect to the transformer's resonance frequency is analyzed This leads to useful scaling laws for the resonance frequency of transformers in dependence of the operating frequency and construction parameters. Finally, a transformer prototype and efficiency and power density values for the DC-DC stage are presented.
Younger Matched Unrelated Donors Confer a Decreased Relapse Risk As Compared to Older Sibling Donors for Adult B-Cell ALL Patients Undergoing Allogeneic Hematopoietic Cell Transplantation (2023)

Primary cell therapy continues to face significant hurdles to therapeutic translation including the inherent variations that exist from donor to donor, batch to batch, and scale-up driven modifications to the manufacturing process. Cardiosphere-derived cells (CDCs) are stromal/progenitor cells with clinically demonstrated tissue reparative capabilities. Mechanistic investigations have identified canonical Wnt/β-catenin signaling as a therapeutic potency marker, and THY1 (CD90) expression as inversely correlated with potency. Here we demonstrate that the cardiosphere formation process increases β-catenin levels and enriches for therapeutic miR content in the extracellular vesicles of these cells, namely miR-146a and miR-22. We further find that loss of potency is correlated with impaired cardiosphere formation. Finally, our data show that small GSK3β inhibitors including CHIR, and BIO and “pro-canonical Wnt” culturing conditions can rescue β-catenin signaling and reduce CD90 expression. These findings identify strategies that could be used to maintain CDC potency and therapeutic consistency.
Characterization of insertion sites and development of locus-specific assays for three broiler-derived subgroup E avian leukosis virus proviruses (2013)

This report deals with the identification of novel elements belonging to a family of endogenous retroviruses, designated endogenous avian leukosis virus-type proviral elements (ALVE), that reside in the genome of the chicken and are closely related to exogenous avian leukosis viruses. The study of ALVE elements in the chicken genome serves as a model system for understanding the interplay between endogenous viruses and their vertebrate hosts in general, including humans. In this report, we characterize the insertion sites and describe locus-specific, diagnostic polymerase chain reaction-based assays for three previously discovered, but as yet not localized, ALVE elements. In addition, we assess the proviral integrity, provide the complete element sequence and examine the genomic environs of the three broiler-derived elements.
Polymerization of styrene with Mg(OH)xCl2-x (x = 0-2)-supported Ti(OBu)4 catalysts combined with methylaluminoxane (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolymerization of styrene with Mg(OH)xCl2-x (x = 0-2)-supported Ti(OBu)4 catalysts combined with methylaluminoxaneKazuo Soga and Takashi MonoiCite this: Macromolecules 1990, 23, 5, 1558–1560Publication Date (Print):March 1, 1990Publication History Published online1 May 2002Published inissue 1 March 1990https://pubs.acs.org/doi/10.1021/ma00207a055https://doi.org/10.1021/ma00207a055research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Biofunctional Nanodot Arrays in Living Cells Uncover Synergistic Co‐Condensation of Wnt Signalodroplets (Small 50/2022) (2022)

Wnt Signalodroplets High-density arrays of biofunctionalized nanodots with diameters of 300 nm enable spatially controlled assembly of active Wnt signaling platforms in the plasma membrane. Massive parallelization at the single cell level uncovers receptor density-dependent co-condensation of cytosolic effector proteins, suggesting a digitalized transmembrane signaling controlled by liquid–liquid phase separation. More details can be found in article number 2203723 by Martin Steinhart, Jacob Piehler, Changjiang You, and co-workers.
A direct-to-ground architecture for supporting commercial communications from the International Space Station (2003)

We outline the first steps of an effort to start defining a communications architecture for supporting broadband data communications from the International Space Station. We focus on a direct-to-ground architecture, which could serve as an intermediate solution to satisfy the near term communications needs of commercial experiments and payloads on the ISS and overcome certain limitations of the current ISS communications infrastructure. We address three communications options and evaluate an architecture for the direct-to-ground option, focusing on a particular user's requirements, communications links, and coverage availability. We also discuss system, mobility support and protocol issues that need to be addressed for this solution to be a feasible alternative.
Pathophysiology of Ultrafiltration in Peritoneal Dialysis (1990)

Pathophysiology of peritoneal ultrafiltration is analyzed in the present study. Peritoneal equilibration test is the easiest procedure to study in detail the possible causes of failure to control the ultrafiltration rate in patients undergoing peritoneal dialysis. Membrane failure, reduction in peritoneal blood flow, excessive lymphatic reabsorption catheter malposition, and fluid sequestration are the most common causes of ultrafiltration loss. Pharmacologic manipulation of peritoneal membrane, correction of mechanical inconvenients, reduction in peritonitis rate and in the level of immunostimulation of the mesothelial macrophages, together with a careful policy in terms of glucose concentration in the dialysate and dwell times may contribute not only to treat different forms of ultrafiltration loss but also to prevent their incidence.
The Mechanism of Low-Temperature Oxidation of Carbon Monoxide by Oxygen over the PdCl2–CuCl2/γ-Al2O3 Nanocatalyst (2018)

The state of palladium and copper on the surface of the PdCl₂-CuCl₂/γ-Al₂O₃ nanocatalyst for the low-temperature oxidation of CO by molecular oxygen was studied by various spectroscopic techniques. Using X-ray absorption spectroscopy (XAS), powder X-ray diffraction (XRD), and diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), freshly prepared samples of the catalyst were studied. The same samples were also evaluated after interaction with CO, O₂, and H₂O vapor in various combinations. It was shown that copper exists in the form of Cu₂Cl(OH)₃ (paratacamite) nanophase on the surface of the catalyst. No palladium-containing crystalline phases were identified. Palladium coordination initially is comprised of four chlorine atoms. It was shown by XAS that this catalyst is not capable of oxidizing CO at room temperature in the absence of H₂O and O₂ over 12 h. Copper(II) and palladium(II) are reduced to Cu(I) and Pd(I,0) species, respectively, in the presence of CO and H₂O vapor (without O₂). It was found by DRIFTS that both linear (2114 cm<sup>-1</sup>, 1990 cm<sup>-1</sup>) and bridging (1928 cm<sup>-1</sup>) forms of coordinated CO were formed upon adsorption onto the catalyst surface. Moreover, the formation of CO₂ was detected upon the interaction of the coordinated CO with oxygen. The kinetics of CO oxidation was studied at 18-38 °C at an atmospheric pressure for CO, O₂, N₂, and H₂O (gas) mixtures in a flow reactor (steady state conditions).
Ultrastrong, Ultraflexible, and Ultratransparent Polyethylene Cellular Nanofilms (2020)

Light weight and mechanically robust cellular polymer nanofilms provide materials solutions to many cutting-edge technologies, such as high-flux membrane filtration, ultrathin flexible energy storage, and skin-conformable devices. However, it remains challenging to fabricate hand manipulatable cellular polymer nanofilms for use as self-standing structural materials. Herein, we used a sequential planar extension approach to transform low-entanglement ultrahigh molecular weight polyethylene (UHMWPE) gel films dispersed in porogenic polyethylene oligomers into cellular nanofilms consisting of stretch-dominated triangular cells of molecularly anisotropic cell edges. The microstructure afforded the cellular nanofilm, which had a thickness down to 20 nm, with a unique combination of ultratransparency (&gt;98.5%), ultrahigh in-plane tensile strength (1071 MPa.cm^3.g^(-1)), and ultrahigh flexibility: a 43 nm thick film can deflect reversibly up to 8.0 mm in depth (185,000 times) under a spherical indentation load. As an application, we fabricated the nanofilm into a freestanding ultratransparent respiratory face covering. The new polyethylene cellular nanofilms are expected to represent a new class of platform membranes for advancing fundamental and technological development.