gebhart/patrepeval huggingface dataset:
Deoxygenated inositol 1,4,5-trisphosphate analogs and their interaction with metabolic enzymes. (1R,2R,4R)-Cyclohexane-1,2,4-tris(methylenesulfonate): a potent selective 5-phosphatase inhibitor (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleDeoxygenated inositol 1,4,5-trisphosphate analogs and their interaction with metabolic enzymes. (1R,2R,4R)-Cyclohexane-1,2,4-tris(methylenesulfonate): a potent selective 5-phosphatase inhibitorAlan P. Kozikowski, Vassil I. Ognyanov, Chinpiao Chen, Abdul H. Fauq, Stephen T. Safrany, Robert A. Wilcox, and Stefan R. NahorskiCite this: J. Med. Chem. 1993, 36, 20, 3035–3038Publication Date (Print):October 1, 1993Publication History Published online1 May 2002Published inissue 1 October 1993https://pubs.acs.org/doi/10.1021/jm00072a027https://doi.org/10.1021/jm00072a027research-articleACS PublicationsRequest reuse permissionsArticle Views154Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Self-limited layer-by-layer etching of Si by alternated chlorine adsorption and Ar+ ion irradiation (1993)

We report the observation of self-limited layer-by-layer etching of Si by alternated chlorine adsorption and low energy Ar+ ion irradiation using an ultraclean electron-cyclotron-resonance plasma apparatus. The etch rate per cycle increased with the chlorine supplying time and saturated to a constant value of about 1/2 atomic layer per cycle for Si(100) and 1/3 for Si(111), which was independent of the chlorine partial pressure in the range of 1.3–6.7 mPa. These results indicate that etching was determined by self-limited adsorption of chlorine. Moreover, the chlorine adsorption rate was found to be described by a Langmuir-type equation with an adsorption rate constant k=83 and 110 (Pa s)−1 for Si(100) and Si(111), respectively.
Preclinical Therapeutic Assessment of a New Chemotherapeutics [Dichloro(4,4’-Bis(2,2,3,3-Tetrafluoropropoxy) Methyl)-2,2’-Bipryridine) Platinum] in an Orthotopic Patient-Derived Xenograft Model of Triple-Negative Breast Cancers (2022)

Cisplatin is one of the most common therapeutics used in treatments of several types of cancers. To enhance cisplatin lipophilicity and reduce resistance and side effects, a polyfluorinated bipyridine-modified cisplatin analogue, dichloro[4,4'-bis(2,2,3,3-tetrafluoropropoxy)methyl)-2,2'-bipryridine] platinum (TFBPC), was synthesized and therapeutic assessments were performed. TFBPC displayed superior effects in inhibiting the proliferation of several cisplatin-resistant human cancer cell lines, including MDA-MB-231 breast cancers, COLO205 colon cancers and SK-OV-3 ovarian cancers. TFBPC bound to DNA and formed DNA crosslinks that resulted in DNA degradation, triggering the cell death program through the PARP/Bax/Bcl-2 apoptosis and LC3-related autophagy pathway. Moreover, TFBPC significantly inhibited tumor growth in both animal models which include a cell line-derived xenograft model (CDX) of cisplatin-resistant MDA-MB-231, and a patient-derived xenograft (PDX) model of triple-negative breast cancers (TNBCs). Furthermore, the biopsy specimen from TFBPC-treated xenografts revealed decreased expressions of P53, Ki-67 and PD-L1 coupled with higher expression of cleaved caspase 3, suggesting TFBPC treatment was effective and resulted in good prognostic indications. No significant pathological changes were observed in hematological and biochemistry tests in blood and histological examinations from the specimen of major organs. Therefore, TFBPC is a potential candidate for treatments of patients suffering from TNBCs as well as other cisplatin-resistant cancers.
Surrogate model development for optimized blended-wing-body aerodynamics (2022)

International audience
Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines (2022)

Understanding vaccine-elicited protection against SARS-CoV-2 variants and other sarbecoviruses is key for guiding public health policies. We show that a clinical stage multivalent SARS-CoV-2 spike receptor-binding domain nanoparticle vaccine (RBD-NP) protects mice from SARS-CoV-2 challenge after a single immunization, indicating a potential dose-sparing strategy. We benchmarked serum neutralizing activity elicited by RBD-NP in non-human primates against a lead prefusion-stabilized SARS-CoV-2 spike (HexaPro) using a panel of circulating mutants. Polyclonal antibodies elicited by both vaccines are similarly resilient to many RBD residue substitutions tested although mutations at and surrounding position 484 have negative consequences for neutralization. Mosaic and cocktail nanoparticle immunogens displaying multiple sarbecovirus RBDs elicit broad neutralizing activity in mice and protect mice against SARS-CoV challenge even in the absence of SARS-CoV RBD in the vaccine. This study provides proof of principle that multivalent sarbecovirus RBD-NPs induce heterotypic protection and motivates advancing such broadly protective sarbecovirus vaccines to the clinic.
A Diagonal Splitting Algorithm for Adaptive Group Testing (2023)

Group testing enables to identify infected individuals in a population using a smaller number of tests than individual testing. To achieve this, group testing algorithms commonly assume knowledge of the number of infected individuals; nonadaptive and several adaptive algorithms fall in this category. Some adaptive algorithms, like binary splitting, operate without this assumption, but require a number of stages that may scale linearly with the size of the population. In this paper we contribute a new algorithm that enables a balance between the number of tests and the number of stages used, and which we term diagonal group testing. Diagonal group testing, like binary splitting, does not require knowledge of the number of infected individuals, yet unlike binary splitting, is order-optimal w.r.t. the expected number of tests it requires and is guaranteed to succeed in a small number of stages that scales at most logarithmically with the size of the population. Numerical evaluations, for diagonal group testing and a hybrid approach we propose, support our theoretical findings.
Adaptive Prediction of RR interval for online MR parameters changes (2007)

Cardiac MRI sequences are generally synchronized on the R wave of the ECG and the read out is done in the ventricular iastole. Depending to the heart rate (HR) and so on the RR interval, an optimal trigger delay (TD), an acquisition time (AT) (which is a function of MR parameters) and a trigger window (TW) are defined before scanning. For Black Blood acquisition, IR pulses are currently played directly on the R wave to have an inversion time (TI) of the blood on read out. Unfortunately, physiological changes of the RR timing especially during breath hold make all these fixed timings non optimum. Additionally, optimal TI for complete nulling of wash in blood is not always compatible with HR > 85 bpm. Moreover, if acquisition of systolic phase is desired, these IR pulses have to be place before the current R wave in the preceding heart cycle. We propose a prediction of the next RR duration based on previous RR cycles. The prediction of RR interval will be used to adapt MR timing parameters (TD, TW, TI, AT) during scanning and enable black blood images in the systolic phase.
Efficient Energy Transfer in Mixed Columnar Stacks of Hydrogen‐Bonded Oligo(p‐phenylene vinylene)s in Solution (2004)

Ultrafast energy transfer has been observed in mixed supramolecular stacks of mono-functionalized oligo(phenylene vinylene)s (MOPVs) in solution. Extended columnar aggregates of MOPV3 incorporating MOPV4 show a very efficient quenching of the MOPV3 fluorescence, which indicates that energy transfer (ENT) occurs within the supramolecular stacks from the shorter oligomer to the longer one (see schematic representation).
A Description of the rUNSWift 2003 Legged Robot Soccer Team (2003)

This paper describes the 2003 world champion legged robot soccer team, rUNSWift. The 2003 rUNSWift team is enhanced in a num- ber of ways over previous teams; both long and short range collabo- ration between team members was carefully crafted, a new method of ball localization was used when the ball was close, new tools were de- veloped for developing filters for objects returned by the vision code, self-localization was simplified, opponent localization was significantly improved with distributed data fusion, ball tracking was improved to account for the ball's velocity, edges and lines on the field were used to assist in self-localization, and automatic gait optimization was used to improve the forward walking speed of the robots. The result of these changes is a team that is significantly improved over previous teams.
Growth Inhibition of Human Hepatoma and Bladder Carcinoma Cells by DNA Topoisomerae Inhibitor β-lapachone (2005)

남미지역에서 자생하는 Tabebuia avellanedae라는 나무의 수피에서 동정된 quinone계 물질이며, DNA topoisomeras억제제로 알려진 <TEX>$\beta-lapachone$</TEX>의 항암작용에 관한 부가적인 자료를 얻기 위하여 인체 간암(HepG2) 및 방광암(T24)세포를 대상으로 조사한 결과 다음과 같은 결과를 얻게 되었다. MTT assay 및 flow cytometry 분석 등의 결과에서, <TEX>$\beta-lapachone$</TEX>의 처리에 따라 조사된 두 가지 암세포에서 <TEX>$\beta-lapachone$</TEX>처리 농도의존적으로 암세포의 심한 형태적 변형이 동반되면서 암세포의 증식이 억제되었으며, 생존율이 저하되었고 이는 apoptosis유발과 상관성이 있음을 알 수 있었다. <TEX>$\beta-lapachone$</TEX>처리에 의한 두 암세포의 증식억제는 종양억제 유전자 p53 및 Cdk inhibitor p21의 발현과는 큰 연관성이 없음을 RT-PCR 및 Western blot analysis를 통하여 확인하였다. 그러나 전사조절인자 Sp-1 및 세포증식 주요조절인자인 PCNA의 단백질 발현은 <TEX>$\beta-lapachone$</TEX>처리에 따라 매우 감소되었으며, telomere조절에 중요한 인자들의 선택적 발현 저하 현상도 관찰되었다. 이상의 결과들은 인체 암세포에서 <TEX>$\beta-lapachone$</TEX>의 항암작용을 이해하는 중요한 자료가 될 것이며, <TEX>$\beta-lapachone$</TEX>과 유사한 화학적 구조 및 성질을 가지는 항암제 후보물질들의 항암기전 비교 및 항암제 개발을 위한 기초 자료로서 응용될 것이다. The objective of the present study was to investigate the effect of <TEX>$\beta-lapachone$</TEX>, a quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) in South America, on the cell growth of human hepatoma (HepG2) and bladder (T24) carcinoma cells. Exposure of cancer cells to <TEX>$\beta-lapachone$</TEX> resulted in growth inhibition, morphological changes and apoptosis in a concentration-dependent manner, which could be proved by MTT assay and flow cytometry analysis. Reverse transcription-polymerase chain reaction (RT-PCR) and Western blot analyses revealed that <TEX>$\beta-lapachone$</TEX> did not affect the levels of tumor suppressor p53 and cyclin-dependent kinase (Cdk) inhibitor p21 (WAFl/CIPl) expression. However, the transcriptional factor Sp-l and proliferating cell nuclear antigen (PCNA) protein levels were significantly down-regulated by <TEX>$\beta-lapachone$</TEX> in both cell lines. Moreover, <TEX>$\beta-lapachone$</TEX> treatment caused a dose-dependent inhibition of the expression of telomere regulatory gene products such as human telomere reverse transcriptase (hTERT) and telomerase-associated protein-l (TEP-l). Taken together, these findings suggest that <TEX>$\beta-lapachone$</TEX>-induced inhibition of human hepatoma and bladder carcinoma cell proliferation is associated with the induction of apoptotic cell death via modulation of several major growth regulatory gene products, and provide important new insights into the additional mechanisms of the anti-cancer activity of <TEX>$\beta-lapachone$</TEX>.
The Hitchhiker’s Guide to Fused Twins: A Review of Access to Digital Twins In Situ in Smart Cities (2022)

Smart Cities already surround us, and yet they are still incomprehensibly far from directly impacting everyday life. While current Smart Cities are often inaccessible, the experience of everyday citizens may be enhanced with a combination of the emerging technologies Digital Twins (DTs) and Situated Analytics. DTs represent their Physical Twin (PT) in the real world via models, simulations, (remotely) sensed data, context awareness, and interactions. However, interaction requires appropriate interfaces to address the complexity of the city. Ultimately, leveraging the potential of Smart Cities requires going beyond assembling the DT to be comprehensive and accessible. Situated Analytics allows for the anchoring of city information in its spatial context. We advance the concept of embedding the DT into the PT through Situated Analytics to form Fused Twins (FTs). This fusion allows access to data in the location that it is generated in in an embodied context that can make the data more understandable. Prototypes of FTs are rapidly emerging from different domains, but Smart Cities represent the context with the most potential for FTs in the future. This paper reviews DTs, Situated Analytics, and Smart Cities as the foundations of FTs. Regarding DTs, we define five components (physical, data, analytical, virtual, and Connection Environments) that we relate to several cognates (i.e., similar but different terms) from existing literature. Regarding Situated Analytics, we review the effects of user embodiment on cognition and cognitive load. Finally, we classify existing partial examples of FTs from the literature and address their construction from Augmented Reality, Geographic Information Systems, Building/City Information Models, and DTs and provide an overview of future directions.
Occupancy of serotonin and norepinephrine transporter by milnacipran in patients with major depressive disorder: a positron emission tomography study with [11C]DASB and (S,S)-[18F]FMeNER-D2 (2012)

Antidepressants used for treatment of depression exert their efficacy by blocking reuptake at serotonin transporters (5-HTT) and/or norepinephrine transporters (NET). Recent studies suggest that serotonin and norepinephrine reuptake inhibitors that block both 5-HTT and NET have better tolerability than tricyclic antidepressants and may have higher efficacy compared to selective serotonin reuptake inhibitors. Previous positron emission tomography (PET) studies have reported >80% 5-HTT occupancy with clinical doses of antidepressants, but there has been no report of NET occupancy in patients treated with antidepressants. In the present study, we investigated both 5-HTT and NET occupancies by PET using radioligands [(11)C]DASB and (S,S)-[(18)F]FMeNER-D(2), in six patients, each with major depressive disorder (MDD), using various doses of milnacipran. Our data show that mean 5-HTT occupancy in the thalamus was 33.0% at 50 mg, 38.6% at 100 mg, 60.0% at 150 mg and 61.5% at 200 mg. Mean NET occupancy in the thalamus was 25.3% at 25 mg, 40.0% at 100 mg, 47.3% at 125 mg and 49.9% at 200 mg. Estimated ED(50) was 122.5 mg with the dose for 5-HTT and 149.9 mg for NET. Both 5-HTT and NET occupancies were observed in a dose-dependent manner. Both 5-HTT and NET occupancies were about 40% by milnacipran at 100 mg, the dose most commonly administered to MDD patients.
Synergistic activity of rabbit granulocyte peptides against Candida albicans (1986)

Rabbit granulocytes contain six antimicrobial peptides that are structurally homologous to the human neutrophil "defensins." NP-5, a rabbit defensin, lacks significant activity against Candida albicans. Nevertheless, its addition to submicromolar concentrations of rabbit NP-1, NP-2, or NP-3a potentiates their candidacidal effect. Thus, granulocyte defensins can act synergistically against potential pathogens.
Evaluating Heterogeneous Information Access (Position Paper) (2013)

Information access is becoming increasingly heterogeneous. We need to better understand the more complex user behaviour within this context so that to properly evaluate search systems dealing with heterogeneous information. In this paper, we review the main challenges associated with evaluating search in this context and propose some avenues to incorporate user aspects into evaluation measures.
Accelerated Thymic Maturation and Autoreactive T Cells in Bronchopulmonary Dysplasia (2006)

These observations suggest that bombesin-like peptides mediate premature thymic maturation and thymic nurse-cell depletion, leading to autoreactive T cells that could contribute to lung injury.
Wear Test Demonstration of a Technique to Mitigate Keeper Erosion in a High-Current LaB 6 Hollow Cathode (2016)

The results of a wear test on a 100-A LaB6 hollow cathode are presented as verification of a technique to mitigate keeper erosion caused by sputtering from anomalously high-energy ions. The ions responsible for this erosion have been theorized to result from the onset ion acoustic turbulence in the plume of the cathode. The proposed technique to minimize the erosion relies on identifying operating conditions where the energy of the ion acoustic turbulence is low. 100 hour wear tests are conducted on a high-current hollow cathode with a molybdenum keeper at three operating conditions: two with low turbulence levels and one with high turbulence levels. It is demonstrated that the keeper exhibits low levels erosion (at a peak erosion rate of around 0.035 um/hour) that can be explained by classical mechanisms at the low turbulence states, and anomalously high sputtering (at a peak erosion rate of.07 um/hour) at the high erosion state.
Dynamin and reverse-mode sodium calcium exchanger blockade confers neuroprotection from diffuse axonal injury (2019)

Mild traumatic brain injury (mTBI) is a frequently overlooked public health concern that is difficult to diagnose and treat. Diffuse axonal injury (DAI) is a common mTBI neuropathology in which axonal shearing and stretching induces breakdown of the cytoskeleton, impaired axonal trafficking, axonal degeneration, and cognitive dysfunction. DAI is becoming recognized as a principal neuropathology of mTBI with supporting evidence from animal model, human pathology, and neuroimaging studies. As mitochondrial dysfunction and calcium overload are critical steps in secondary brain and axonal injury, we investigated changes in protein expression of potential targets following mTBI using an in vivo controlled cortical impact model. We show upregulated expression of sodium calcium exchanger1 (NCX1) in the hippocampus and cortex at distinct time points post-mTBI. Expression of dynamin-related protein1 (Drp1), a GTPase responsible for regulation of mitochondrial fission, also changes differently post-injury in the hippocampus and cortex. Using an in vitro model of DAI previously reported by our group, we tested whether pharmacological inhibition of NCX1 by SN-6 and of dynamin1, dynamin2, and Drp1 by dynasore mitigates secondary damage. Dynasore and SN-6 attenuate stretch injury-induced swelling of axonal varicosities and mitochondrial fragmentation. In addition, we show that dynasore, but not SN-6, protects against H<sub>2</sub>O<sub>2</sub>-induced damage in an organotypic oxidative stress model. As there is currently no standard treatment to mitigate cell damage induced by mTBI and DAI, this work highlights two potential therapeutic targets for treatment of DAI in multiple models of mTBI and DAI.
Parimutuel Betting Markets as Information Aggregation Devises: Experimental Results (1997)

The demonstrated capacity of markets to aggregate information motivates research on alternative institutions designed to do the same task. This study inquires about forms of parimutuel betting systems. Measures of information aggregation for performance evaluation are introduced. Two environments are studied. The first poses a simpler aggregation problem than does the second. Information aggregation can be detected under both environments but the degree depends on the choice of baselines. The competitive equilibrium rational expectations model is clearly the best model in the simpler environment but, in the more complex environment, models based on private information alone are more accurate. Bluffing and waiting inhibit aggregation and time and experience are conjectured to lead to more rational expectations-like performance. Copyright Springer-Verlag Berlin Heidelberg 2003 (This abstract was borrowed from another version of this item.)
Bayesian multi-target localization using blocking statistics in multipath environments (2015)

Passive localization based on distributed MIMO radar has a wide variety of applications ranging from security/military to consumer support. This paper considers the problem of localizing a (passive) target through time-of-arrival measurements from a number of (distributed) single-antenna transmitters to distributed receivers in the presence of objects that can block the line of sight between transmitter/receiver and target. The key effect investigated in this paper is the correlation of the blocking between an object and different transmitters/receivers. We formulate the problem in a Bayesian framework and suggest a sub-optimum but efficient algorithm to solve this problem; simulations show considerably better performance than can be achieved by ignoring the blocking statistics.
Porphyromonas gingivalis enzymes enhance infection with human metapneumovirus in vitro (2011)

Relatively recently discovered, human metapneumovirus (HMPV) is a human pathogen with worldwide prevalence, accounting for a substantial percentage of respiratory tract diseases. Concurrent viral and bacterial infections enable intricate mechanisms of cooperation between pathogens, which complicate the symptoms and outcome of the disease. Such bilateral interactions are based on the modulation of bacterial growth on epithelium pathologically altered during viral illness and the modulation of immune responses, as well as the enhancement of virus replication by bacterial virulence factors. This study showed that proteases produced by Porphyromonas gingivalis, a Gram-negative bacterium implicated in the development of periodontitis, named gingipains, facilitated HMPV replication in LLC-MK2 cells and may contribute to HMPV pathogenicity in patients with periodontitis. Gingipains at low nanomolar concentrations enabled HMPV replication and allowed virus propagation in vitro. In contrast to previously published data for influenza virus, however, Staphylococcus aureus proteases and human neutrophil elastase did not affect virus replication.
Optical Fiber Photonic Crystal Hydrophone for Acoustic Bio-Sensing (2021)

We fabricate, assemble, and characterize a compact, robust, and scalably-fabricated photonic crystal hydrophone capable of measuring acoustic signals from single cardiomyocytes with a minimum detectable pressure of 3 µPa/√Hz and a 19 kHz band-width.