gebhart/patrepeval huggingface dataset:
Fully Printed Organic Electrochemical Transistors from Green Solvents (2019)

Abstract To achieve the full potential of scalable and cost‐effective organic electronic devices, developments are being made in both academic and industry environments to move toward continuous solution‐processing techniques that make use of safe and environmentally benign “green” solvents. In this work, the first example of a transistor device that is fully solution processed using only green solvents is demonstrated. This achievement is enabled through a novel multistage cleavable side chain process that provides aqueous solubility for semiconducting conjugated polymers, paired with aqueous inkjet printing of PEDOT:PSS electrodes, and a solution deposited ion gel electrolyte as the dielectric layer. The resulting organic electrochemical transistor devices operate in accumulation mode and reach maximum transconductance values of 1.1 mS at a gate voltage of − 1 V. Normalizing the transconductance value to the channel dimensions yields g m / W = 2200 S m −1 ( µC * = 22 F cm −1 V −1 s −1 ), making these devices suitable for a range of applications requiring small signal amplification such as transistors, biosensors, and ion pumps. This new material design and device process paves the way toward scalable, safe, and efficient production of organic electronic devices.
Molecular characterization of U937‐dependent T‐cell co‐stimulation (1999)

U937 cells provide a co-stimulatory signal for CD3-mediated T-cell activation which is independent of the CD28/CD80/CD86 interaction. This study set out to identify which molecules contribute to this co-stimulatory activity. Monoclonal antibodies (mAb) to the known accessory molecules CD11a, CD18, CD54 and CD45, all inhibited T-cell proliferation. Although CD11a/18 mAb inhibited U937/T-cell cluster formation as well as proliferation, CD45 enhanced the size of the clusters formed, suggesting that this was not the only mechanism of inhibition. The alternative co-stimulatory pathway provided by U937 cells preferentially stimulated a response in the CD18+ T-cell population, and this reflected the reduced sensitivity of CD8+ T cells to CD28-mediated activation. Monoclonal antibodies to three molecules, CD53, CD98 and CD147, also inhibited U937-dependent T-cell proliferation. The mAb to CD98 and CD147 were inhibitory when prepulsed on to the U937 cells, suggesting an effect mediated by these molecules on the antigen-presenting cell.
AB001. Innate immunity, aging and angiogenesis (2018)

: Disorders of lipid metabolism and macrophage function have been implicated in tissue aging and in diseases such as age-related macular degeneration (AMD). Genetic studies and expression profiling have identified widespread abnormalities in cholesterol metabolism in the aging macrophage. In addition, the molecular pathways that regulate the transition from aging to disease have not been elucidated. The current status regarding the mechanisms that regulate macrophage aging and the molecular mechanisms of transition to disease in the context of AMD will be presented with a special focus on factors that influence pathologic angiogenesis and neurodegeneration.
Laser rock drilling by a super-pulsed CO2 laser beam (2002)

High power carbon dioxide lasers have successfully been used in drilling or cutting engineering materials such as metals, polymers and ceramics over the years. Can a carbon dioxide laser be used to efficiently drill different rocks in a deep gas well? Research sponsored by US Department of Energy has been carried out to answer this question. This paper will report the study results of using a super-pulsed CO2 laser beam to drill rocks. A 6 kW CO2 laser operated at superpulse mode was used to carry out the tests. Both linear tracks and deep holes were produced on the rocks. The energy required to remove a unit volume of rock, specific energy, was determined. Test results show that superpulsed CO2 laser beam can be efficiently used to drill deep, large diameter holes in petroleum rocks with the assistance of purging gas.
High precision measurement of surface cracks using an optical system (2009)

In this contribution an advanced technique to measure the width of surface cracks in concrete is presented. The goal is to provide a system for laboratory applications with a high resolution in order to be able to estimate the stabilization of surface cracks in the range of 0–250 μm during laboratory loading tests. Using digital imaging and suitable image processing algorithms, an automated system for the determination of crack widths was developed. A 4 megapixel monochrome digital camera was used in combination with a special telecentric lens, in order to achieve a resolution of 1 μm per pixel. The main challenge in this work was to develop a robust image processing algorithm, which determines the surface crack width under changing environmental conditions, especially in terms of ambient light.
Knowledge, value, opinion and practice about usage of pit and fissure sealant among dental professionals in Chennai, Tamil Nadu, India (2015)

The results suggest that dental practitioners had satisfactory knowledge about pit and fissure sealant and had neutral attitudes about sealants being effective. Dental practitioners adequately used the pit and fissure sealants but they did not follow the standardized procedures and specific guidelines.
Surface NMR instrumentation and methods for detecting and characterizing water in the vadose zone (2013)

ABSTRACT A commercially available surface NMR instrument was modified to address the challenges of using earth’s field surface NMR to detect and characterize water in the unsaturated (or vadose) zone. The modified instrument incorporates faster switching electronics to achieve an instrument dead time of 2.8 ms, and higher output power electronics to enable a maximum coil voltage of 8000 volts and coil current of 800 amps. The instrument was used to collect and interpret surface NMR data at several active vadose zone investigation sites in the western US. A 6‐week surface NMR experiment was conducted at a managed aquifer storage and recovery facility in Arizona, to explore the measurement capabilities and limitations of the instrument, during a managed infiltration event. The resulting time lapse surface NMR data were used to map zones of held water prior to the flood event, image the influx of water through the top 15 metres of the subsurface during and after the event, quantify the spatial and temporal distribution of infiltrating water throughout the event, and characterize the distribution of water in different relative pore sizes throughout the event. Data obtained at pseudo‐static vadose zone investigation sites indicate that the surface NMR instrument can detect and image some forms of water held in unconsolidated vadose zone formations, at depths up to 30 metres. Complementary NMR logging data indicate that the surface NMR instrument does not detect all of the water held in these pseudo‐static formations, but that the non‐invasive surface NMR data may yield valuable information nonetheless.
Synthesis of Microwave Concave Semitransparent Screen for Reduction of Radiation in the Shadow Domain (2019)

Semitransparent concave screens are viewed as means of reducing radiation in nonworking angular area of an antenna (shadow domain). An analytical procedure for synthesis of screen impedance in the geometrical optics (GO) approximation has been developed. Beyond the limits of the GO approximation, the numerical synthesis procedure has been applied. It has been shown that it is the radii of the screen that defines the achievable cutoff of the fields. To achieve a cutoff on the order of -20 dB in the angular sector of + - 10 degrees with respect to the desired boundary of the shadow domain, the radii of the concave screen is shown to be 2 wavelengths. An example of a compact antenna system for high precision satellite positioning is also presented.
A novel measurement device for volume management in lower limb amputees: A technical note (2013)

Many amputees suffer from irritation and wounds as a result of poor residual limb volume management. Reasons contributing to failure to maintain volume properly include peripheral neuropathy, cognitive impairment, and social/cultural issues. Amputees commonly use socks of various thicknesses to account for diurnal limb volume loss. However, data relating to sock compliance is lacking due to an absence of a reliable way to collect usage data. A device was fabricated utilizing wireless RFID and socket-limb interface force detection technology to track sock usage and activity of an amputee. Pilot data was collected through both in-lab and out-of-lab protocols. The collected data showed encouraging results tracking interface force data, however accurate sock data collection was difficult. Suggested solutions include designing a more effective antenna and using the interface force data to detect limb presence to start a tag accumulator algorithm. Clinical applications for the Sock Monitor include intervention through alerting the amputee of a need for a sock change before tissue damage occurs and evidence for prosthetists to justify insurance reimbursement for components and socket replacements. The next step is to use a new prototype with better hardware and firmware to collect real-world usage data from a large group of amputees. A predictive model will be made and implemented to determine if intervention in sock usage improves comfort and limb tissue health.
Synthesis, 3D pharmacophore, QSAR and docking studies of novel quinazoline derivatives with nitric oxide release moiety as preferential COX-2 inhibitors (2014)

Four novel series of quinazoline derivatives <bold>IIIa–c</bold>, <bold>VIa–c</bold> and their NO-hybrid molecules as nitrate esters <bold>Va–c</bold> and <bold>VIIIa–c</bold> have been synthesized and evaluated for their anti-inflammatory activity <italic>in vivo</italic> and <italic>in vitro.</italic>
Alterations in gene expression in T1α null lung: a model of deficient alveolar sac development (2006)

This global analysis has identified a number of candidate genes that are significantly altered in lungs in which sacculation is abnormal. Many genes identified were not previously associated with lung development and may participate in formation of alveolar sacs prenatally.
Semi-Crystalline Polyoxymethylene-co-Polyoxyalkylene Multi-Block Telechels as Building Blocks for Polyurethane Applications (2022)

Hydroxy-terminated polyoxymethylene-<i>co</i>-polyoxyalkylene multi-block telechels were obtained by a new methodology that allows for the formal substituting of ether units in polyether polyols with oxymethylene moieties. An interesting feature is that, unlike carbonate groups in polycarbonate and polyethercarbonate polyols, homopolymer blocks of polyoxymethylene moieties can be formed. The regular nature of polyoxymethylene blocks imparts a certain crystallinity to the polymer that can give rise to new properties of polyurethanes derived from such telechels. The synthesis, reaction sequence and kinetics of the formation of oligomeric hydroxy-terminated multi-block telechel polyoxymethylene moieties are discussed in this paper and the preparation of a polyurethane material is demonstrated.
Monitoring of interactions between macrophage hybridoma and Trypanosoma cruzi by chemiluminescence (1988)

SCOPUS: ar.j
Use of Recombinant Antigens for Sensitive Serodiagnosis of American Tegumentary Leishmaniasis Caused by Different Leishmania Species (2016)

American tegumentary leishmaniasis (ATL) (also known as cutaneous leishmaniasis [CL]) is caused by various species of protozoa of the genus Leishmania The diagnosis is achieved on a clinical, epidemiological, and pathological basis, supported by positive parasitological exams and demonstration of leishmanin delayed-type hypersensitivity. Serological assays are not routinely used in the diagnosis because many are considered to have low sensitivity and the particular Leishmania species causing the disease can lead to variable performance. In the present study, we generated recombinant versions of two highly conserved Leishmania proteins, Leishmania (Viannia) braziliensis-derived Lb8E and Lb6H, and evaluated both in enzyme-linked immunosorbent assays (ELISA). Recombinant Lb6H (rLb6H) had better performance and reacted with 100.0% of the ATL and 89.4% of the VL samples. These reactions with rLb6H were highly specific (98.5%) when compared against those for samples from healthy control individuals. We then assessed rLb6H against sera from ATL patients infected with different species of Leishmania prevalent in Brazil [Leishmania (Leishmania) amazonensis, L (Viannia) braziliensis, and L (V) guyanensis] and samples from patients with other infectious diseases. In analyses of 500 sera, ELISA using rLb6H detected all 219 ATL samples (sensitivity of 100.0%) with an overall specificity of 93.9% (considering healthy individuals and other infectious diseases patients). Only a minority of samples from Chagas disease patients possessed antibodies against rLb6H, and all of these responses were low (with a highest reactivity index of 2.2). Taken together, our data support further evaluation of rLb6H and the potential for its routine use in the serological diagnosis of ATL.
55.2: Fast Switching Dual‐Frequency Liquid Crystal Optical Retarder, Driven by an Amplitude and Frequency Modulated Voltage (2003)

Abstract We employed amplitude and frequency modulated voltage in fast switching optical retarder with a high pretilt angle dual‐frequency nematic cell. We obtained the response times 150 − 500 μs for an optical retardation shift on 0.3 − 2.2 μm in optical retarder with 12 μm thick nematic cell. The results could be used in beam steering, adaptive optics and display devices.
Future of Database System Architectures (2023)

Over the past two decades, we have experienced major technology disruptions on multiple fronts, none bigger than the emergence of cloud computing, which has led to fundamental changes in how database software is architected. We are seeing several new trends that are similarly shaping the future of data management.
Transcription levels of invasion‐related genes in prostate cancer cells are modified by inhibitors of tyrosine kinase (2006)

Previous reports have shown that genistein and tyrphostin AG-1478, two tyrosine kinase inhibitors (TKIs), exert multiple cellular effects in prostate carcinoma cells, e.g. a reduction in the production of urokinase plasminogen activator (uPA) and its receptor uPAR, and a decrease in the cells' ability to invade an artificial basement membrane. Microarray technology was used to measure alterations in mRNA levels caused by TKI treatment in two prostatic carcinoma cell lines, PC-3 and DU-145. Genistein treatment led to a reduction of at least 50% in 78 genes in PC-3, while 82 were twofold upregulated. In DU-145, the same treatment resulted in a 50% decreased transcript level in 120 genes, and increased expression in 25 genes. Tyrphostin AG-1478 produced a 50% reduction in mRNA levels in 58 genes in DU-145, whereas no alterations were demonstrated using the tyrphostin in PC-3 cells. Among the effects of TKIs, a lowered uPA and uPAR transcription was demonstrated in genistein-treated cells, while a few metalloproteinases (MMPs) were affected. Transcription of various integrin subunits was also downregulated overall. Several alterations in gene transcription were demonstrated in PC-3 and DU-145 after TKI treatment. This knowledge could be of importance in the search for new therapeutic strategies in prostate cancer treatment, and the interplay between the various effects needs to be investigated further.
Fiber-feedback optical parametric oscillator for half-harmonic generation of sub-100-fs frequency combs around 2  μm (2015)

We demonstrate a femtosecond fiber-feedback optical parametric oscillator (OPO) at degeneracy. The OPO cavity comprises an 80-cm-long fiber composed of a combination of normal and anomalous dispersion sections that provide a net intracavity group delay dispersion close to zero. By using a mode-locked, Yb-doped fiber laser as the pump, we achieved half-harmonic generation of 250-MHz, 1.2-nJ nearly transform-limited 97-fs pulses centered at 2090 nm with a total conversion efficiency of 36%.
Evaluation of the Inheritance of the Complex Vertebral Malformation Syndrome by Breeding Studies (2004)

To investigate the congenital complex vertebral malformation syndrome (CVM) in Holstein calves, two breeding studies were performed including 262 and 363 cows, respectively. Cows were selected from the Danish Cattle Database based on pedigree and insemination records. Selected cows were progeny of sires with an established heterozygous CVM genotype and pregnant after insemination with semen from another sire with heterozygous CVM genotype. Following calving the breeders should state, if the calf was normal and was requested to submit dead calves for necropsy. In both studies, significantly fewer CVM affected calves than expected were obtained; a finding probably reflecting extensive intrauterine mortality in CVM affected foetuses. The findings illustrate increased intrauterine mortality as a major potential bias in observational studies of inherited disorders.
The effect of chemically preintercalated alkali ions on the structure of layered titanates and their electrochemistry in aqueous energy storage systems (2020)

We introduce a novel chemical preintercalation based synthesis technique based on hydrogen peroxide induced sol-gel process to obtain alkali ion containing ternary layered titanates (MTO, where M = Li, Na, K). Synthesis parameters leading to the formation of single-phase materials with homogeneous elemental distribution are reported for each of the preintercalated ion. Our analyses indicate that the interlayer spacing in the structure of the layered titanates increases with the increase of the radius of the hydrated preintercalated ion. Scanning and transmission electron microscopy imaging revealed morphological diversity: the LTO phase crystallized as nanoplates assembled in "peony-like" spherical agglomerates while NTO and KTO particles exhibited one-dimensional nanobelt or wire-like morphology, with the KTO nanobelts being shorter and more aggregated than the NTO nanobelts. Structural refinement corroborated by electron diffraction and high-resolution transmission electron microscopy revealed that the structure of the LTO phase is built by stacking Ti-O layers containing a single straight layer of connected TiO<sub>6</sub> octahedra. The layers in NTO and KTO structures form differently and consist of double Ti-O layers with ragged arrangement of units built by TiO<sub>6</sub> octahedra with two titanium rows. The NTO electrodes exhibited the highest electrochemical performance in cells with aqueous 1 M Na<sub>2</sub>SO<sub>4</sub> electrolyte, followed by the KTO electrodes and then LTO electrodes, and this trend is maintained at various scan rates. The established relationships between the structure and electrochemical performance reveal that, in addition to interlayer distance and chemistry of the interlayer region, the structure of the layers can play an important role in charge storage properties of layered oxide electrodes. The double Ti-O layers in the structure of NTO and KTO phases provide a larger number of redox centers which could contribute to the superior electrochemical performance as compared to the LTO electrodes. Our findings indicate that layered materials containing double transition metal oxide layers are promising candidates for exfoliation and assembly with electronically conductive layers with the aim to create 2D heterostructures with high electrochemical performance.
Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase (2006)

A series of imidazole-containing peptidomimetic PFTase inhibitors and their co-crystal structures bound to PFTase and FPP are reported. The structures reveal that the peptidomimetics adopt a similar conformation to that of the extended CVIM tetrapeptide, with the imidazole group coordinating to the catalytic zinc ion. Both mono- and bis-imidazole-containing derivatives, 13 and 16, showed remarkably high enzyme inhibition activity against PFTase in vitro with IC50 values of 0.86 and 1.7 nM, respectively. The peptidomimetics were also highly selective for PFTase over PGGTase-I both in vitro and in intact cells. In addition, peptidomimetics and were found to suppress tumor growth in nude mouse xenograft models with no gross toxicity at a daily dose of 25 mg kg(-1).
Early Events in Vaginal Hiv Transmission: Implications in Microbicide Development (2009)

In vitro models for HIV crossing through mucosae include direct infection of epithelial cells, transcytosis through epithelial cells, epithelial transmigration of infected donor cells, uptake by intraepithelial dendritic cells, and circumvention of the epithelial barrier through physical breaches. Mucosal crossing of HIV for further reaching of the submucosal target cells (macrophages, lymphocytes and dendritic cells) may be modulated by supraepithelial factors, such as seminal complement components (opsonized HIV), by epithelial factors released in the submucosal microenvironment, such as antimicrobial soluble factors, cytokines and chemokines, and by the potent intraepithelial and submucosal innate immunity. Poor understanding of the subtle and complex orchestration of the numerous virus and cell factors involved in HIV mucosal crossing renders the design of effective microbicide formulations difficult. Thus, there is currently no clear relationship between the success of preclinical development of microbicide formulations, using the available assays of anti-HIV efficacy and mucosal toxicity, and its efficacy against HIV acquisition in women enrolled in a large-scale Phase III trial. In addition, the proof of concept that a microbicide formulation may be efficient outside the laboratory has not yet been clearly demonstrated. Finally, there is an urgent need to better understand and modelize the early events occurring during the first hours of HIV contact with the female genital mucosae, especially considering the enormous gaps of knowledge in the understanding of the mechanisms of HIV mucosal crossing through female genital mucosae.
Genome sequencing on both strands: the Janus strategy (1993)

The design of large scale DNA sequencing projects such as genome analysis demands a new approach to sequencing strategy, since neither a purely random nor a purely directed method is satisfactory. We have developed a strategy that combines these two methods in a way that preserves the advantages of both while avoiding their particular limitations. Computer simulations showed that a specific balance of random and directed sequencing was required for the most efficient strategy, termed the Janus strategy, which has been used in the Escherichia coli genome sequencing project. This approach depended on obtaining sequence easily from either strand of a cloned insert, and was facilitated by inversion of the insert in the engineered M13 vector Janus, by site-specific recombination. The inversion was accomplished simply by growth on the appropriate host strain, when the DNA strand incorporated into the new single stranded phage was complementary to that in the original phage, and was sequenced by the same simple protocol as the first strand.