gebhart/patrepeval huggingface dataset:
Expression of GADS enhances FLT3-induced mitogenic signaling (2016)

GADS is a member of a family of SH2 and SH3 domain-containing adaptors that functions in tyrosine kinase-mediated signaling cascades. Its expression is largely restricted to hematopoietic tissues and cell lines. Therefore, GADS is mainly involved in leukocyte-specific protein tyrosine kinase signaling. GADS is known to interact with tyrosine-phosphorylated SHC, BCR-ABL and KIT. The SH2 domain of GADS has a similar binding specificity to that of GRB2 but its SH3 domain displays a different binding specificity, and thus it is involved in other downstream signaling pathways than GRB2. In the present study, we examined the role of GADS in FLT3 signaling. FLT3 is a type III receptor tyrosine kinase, which is mutated in more than 30% of acute myeloid leukemia (AML) and the most common mutations is the internal tandem duplication (ITD) mutations. We observed that expression of GADS enhanced oncogenic FLT3-ITD-induced cell proliferation and colony formation in vitro. In a mouse xenograft model, GADS accelerated FLT3-ITD-dependent tumor formation. Furthermore, expression of GADS induced a transcriptional program leading to upregulation of MYC and mTORC1 target genes. GADS localizes to the cell membrane and strongly binds to ligand-stimulated wild-type FLT3 or is constitutively associated with the oncogenic mutant FLT3-ITD. We mapped the binding sites in FLT3 to pY955 and pY969 which overlaps with the GRB2 binding sites. Expression of GADS enhanced FLT3-mediated phosphorylation of AKT, ERK1/2, p38 and STAT5. Taken together, our data suggests that GADS is an important downstream component of FLT3 signaling and expression of GADS potentiates FLT3-mediated mitogenic signaling.
Silicon photonic devices with Ge quantum dots as light sources (2007)

Although silicon photonics is now attracting much attention and some devices are manufactured already, development of light sources based on Si related materials is still a big issue. In this talk, promising candidates of light sources with Ge quantum dots are introduced and their characteristics are discussed. We fabricated three kinds of structures embedding Ge dots as light sources, that is, micro-cavities with Si/SiGe distributed Bragg reflector (DBR), photonic crystals and micro-disks formed on SOI substrates.
An architectural exploration of via patterned gate arrays (2003)

In this work we investigate the architecture of a Via Patterned Gate Array (VPGA) [1], focusing primarily on: 1) the optimal lookup table (LUT) size; and 2) a comparison the crossbar and switch block routing architectures. Unlike FPGAs, the routing architectures in a VPGA do not dominate the total area of the circuit. Therefore our results suggest that using smaller LUTs results in a much faster and smaller design. In the routing architecture comparison, our results also show that the switch block architecture is inferior to the crossbar architecture in terms of area utilization. As the number of routing tracks grows, the switch block architecture begins to dominate the total area of the design as in the case of the FPGAs.
Development of Lumped Element Kinetic Inductance Detectors for NIKA (2012)

Lumped-element kinetic inductance detectors(LEKIDs) have recently shown considerable promise as direct absorption mm-wavelength detectors for astronomical applications. One major research thrust within the Néel Iram Kids Array (NIKA) collaboration has been to investigate the suitability of these detectors for deployment at the 30-meter IRAM telescope located on Pico Veleta in Spain. Compared to microwave kinetic inductance detectors (MKID), using quarter wavelength resonators, the resonant circuit of a LEKID consists of a discrete inductance and capacitance coupled to a feedline. A high and constant current density distribution in the inductive part of these resonators makes them very sensitive. Due to only one metal layer on a silicon substrate, the fabrication is relatively easy. In order to optimize the LEKIDs for this application, we have recently probed a wide variety of individual resonator and array parameters through simulation and physical testing. This included determining the optimal feed-line coupling, pixel geometry, resonator distribution within an array (in order to minimize pixel cross-talk), and resonator frequency spacing. Based on these results, a 144-pixel Aluminum array was fabricated and tested in a dilution fridge with optical access, yielding an average optical NEP of ~2E-16 W/Hz^1/2 (best pixels showed NEP = 6E-17 W/Hz^1/2 under 4-8 pW loading per pixel). In October 2010 the second prototype of LEKIDs has been tested at the IRAM 30 m telescope. A new LEKID geometry for 2 polarizations will be presented. Also first optical measurements of a titanium nitride array will be discussed.
Supplementary Fig. S1 from Avian Paramyxovirus 4 Antitumor Activity Leads to Complete Remissions and Long-term Protective Memory in Preclinical Melanoma and Colon Carcinoma Models (2023)

&lt;p&gt;Antiviral response to APMV-4 and rAPMV-4 in normal cells.&lt;/p&gt;
Effects of Recombinant Human Erythropoietin (rHuEPO) on Tumor Control in Patients with Cancer-Induced Anemia (2005)

It is well recognized that anemia-induced tumor hypoxia is associated with a reduced sensitivity of tumors to radiation and some forms of chemotherapy. Thus, the correction of lower hemoglobin (Hb) concentrations with recombinant human erythropoietin (rHuEPO) can play an essential role by improving tumor oxygenation. Based on evidence from a number of trials, treatment with rHuEPO will effectively ameliorate anemia and improve quality of life. However, one of the most essential prerequisites for achieving this benefit is the use of rHuEPO in agreement with the evidence-based ASCO/ASH-guidelines recommending a target Hb concentration of 12 g/dl (7.44 mmol/l).
Nanospray ‘taxation’ and how to avoid it (2004)

In mass spectrometric analysis with nanospray ionization, some analytes were found to appear in spectra with a delay of tens of minutes, while a few others could not be detected at all. The effect was found to be related to cation-exchange chromatography with negative charge on the glass surface, and with the most affected peptide or protein ions having strong localization of positive charge in blocks of two or more adjacent basic amino acid residues (e.g. melittin). The 'affinity' to the glass surface was studied with a peptide mixture and bovine serum albumin (BSA) tryptic digest solutions at sub-micromolar concentration. About 20% fewer tryptic peptides could be identified from spectra recorded with a glass nanospray capillary compared to those acquired with either conventional 1 microL/min electrospray or a quartz nanospray capillary. Protein identification studies are not likely to be seriously affected by this loss, but other protein applications, such as investigations of mutations or post-translational modifications, may suffer due to reduced sequence coverage. Ways to avoid losses of useful ions are discussed.
Learning Slice-Aware Representations with Mixture of Attentions (2021)

Real-world machine learning systems are achieving remarkable performance in terms of coarse-grained metrics like overall accuracy and F-1 score. However, model improvement and development often require fine-grained modeling on individual data subsets or slices, for instance, the data slices where the models have unsatisfactory results. In practice, it gives tangible values for developing such models that can pay extra attention to critical or interested slices while retaining the original overall performance. This work extends the recent slice-based learning (SBL)~\cite{chen2019slice} with a mixture of attentions (MoA) to learn slice-aware dual attentive representations. We empirically show that the MoA approach outperforms the baseline method as well as the original SBL approach on monitored slices with two natural language understanding (NLU) tasks.
Lin28 regulates BMP4 and functions with Oct4 to affect ovarian tumor microenvironment (2012)

Emerging evidence suggests that the tumor microenvironment plays a critical role in regulating cancer stem cells (CSCs) and tumor progression through both autocrine and paracrine signaling. Elevated production of bone morphogenetic proteins (BMPs) from human ovarian cancer cells and stroma has been shown to increase CSC proliferation and tumor growth. Here, we report that Lin28, a stem cell factor, binds to BMP4 mRNA in epithelial ovarian carcinoma cells, thereby promoting BMP4 expression at the post-transcriptional level. As co-expression of Lin28 and Oct4 (another stem cell factor) has been implicated in ovarian cancer CSCs, we also determined that high levels of Lin28 are associated with an unfavorable prognosis when co-expressed with high levels of Oct4. Together, these findings uncover a new level of regulation of BMP4 expression and imply a novel Lin28/Oct4/BMP4-mediated mechanism of regulating ovarian tumor cell growth, thus holding potential for the development of new strategies for the diagnosis and treatment of ovarian cancer.
Correction to Atomistic Description of Electron Beam Damage in Nitrogen-Doped Graphene and Single-Walled Carbon Nanotubes (2013)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to Atomistic Description of Electron Beam Damage in Nitrogen-Doped Graphene and Single-Walled Carbon NanotubesToma Susi*, Jani Kotakoski*, Raul Arenal, Simon Kurasch, Hua Jiang, Viera Skakalova, Odile Stephan, Arkady V. Krasheninnikov, Esko I. Kauppinen, Ute Kaiser*, and Jannik C. MeyerCite this: ACS Nano 2013, 7, 8, 7436Publication Date (Web):July 15, 2013Publication History Published online15 July 2013Published inissue 27 August 2013https://pubs.acs.org/doi/10.1021/nn4034629https://doi.org/10.1021/nn4034629correctionACS PublicationsCopyright © 2013 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views831Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (255 KB) Get e-AlertscloseSUBJECTS:Carbon,Carbon nanotubes,Defects in solids,Impurities,Two dimensional materials Get e-Alerts
Expression of mouse CD43 in the B cell lineage of transgenic mice causes impaired immune responses to T‐independent antigens (1997)

CD43 (leukosialin), a sialylated glycoprotein expressed on the surface of most hematopoietic cells, has been implicated in cell adhesion and signaling. However, its precise physiological function remains unclear. We used mouse CD43 (mCD43)-immunoglobulin enhancer-transgenic (TG) mice to study the role of mCD43 in vivo. Previous work revealed that mCD43 expression on mature B cells in these mice resulted in immunodeficiency to T-dependent (TD) antigens (Ag), possibly by impairing B-T cell interactions. In the present study we have immunized the TG mice with the T-independent (TI) Ag fluorescein-(Fl) lipopolysaccharide (LPS) (TI type 1 Ag) and Fl-Ficoll (TI type 2 Ag). Surprisingly, the mCD43-Ig enhancer expressing mice were impaired in their ability to mount humoral responses to both Fl-LPS and Fl-Ficoll, and had decreased numbers of cells responding to Ag in vivo. Flow cytometric analysis was performed on peritoneal B-1 cells, a population which often plays a major role in humoral responses to TI Ag such as bacterial Ag. This analysis revealed similar B220, IgM and CD5 expression patterns for the TG and nontransgenic (NTG) B-1 cells. In addition, purified peritoneal B-1 cells from TG and NTG mice were able to respond to LPS. Stimulation of splenic B cells in vitro with Fl-LPS and Fl-Ficoll revealed that, in contrast to NTG B cell responses, TG B cell responses could not be enhanced by co-culture with T cells. However, soluble T cell factor enhancement of the TG B cell responses was normal. These data suggest that the mCD43 expression on B cells may inhibit cell interactions that are important for enhanced TI Ag responses. The anti-adhesive forces of mucins in general may thus be critical in regulating both TD and TI humoral responses.
25-Gauge vitrectomy (2019)

The attractiveness of a smaller-gauge vitrectomy instrument system is based on the ability to minimize surgically induced trauma from sclerotomy sites, allow self-sealing sclerotomies, improve operative efficiency, and hasten postoperative recovery. Modifications in vitrectomy instrumentation aimed at decreasing the size of instruments must achieve a balance between the ability to achieve smaller incision sizes and maximization of instrument functionality, recognizing that high instrument functionality may not always be compatible with small size. In 1990, de Juan and Hickingbotham19 designed a variety of 25-gauge vitreoretinal instruments for more delicate and precise surgical maneuvers. The infusion rate in a 25-gauge vitrectomy system is lower than that in a routine 20-gauge system, due to the port diameter, which may limit the system’s effectiveness. Eyes with pre-existing filtering blebs and other eyes of patients who require vitrectomy may have underlying conditions that put them at risk for difficult-to-control glaucoma.
Nanostructured Transparent Conducting Oxide Films for Polarization Control with Plasmonic Metasurfaces (2014)

Transparent Conducting Oxides (TCOs) enable the realization of practical plasmonic and metamaterial devices at the telecommunication frequency due to their low optical loss and CMOS compatibility. By employing a conventional dry-etching process, we have fabricated GZO plasmonic waveplates, which convert linearly polarized light into circularly polarized light.
Event-driven IPv6 communication for the smart grid infrastructure (2011)

There is a common understanding that we need to use energy in smarter and more efficient ways. In order to achieve increased energy efficiency for households there is a need to adjust energy consumption based on the dynamic needs of the people living there, and the available energy and costs at a specific time. Involved energy devices, such as electricity, gas and water meters, need to have a certain amount of “smartness” however without a common way to integrate them we risk ending up with a multitude of heterogeneous smart devices that need to be manually controlled one by one via device-specific interfaces and protocols. We believe that using IPv6 on every device is an important step towards creating a controllable and interoperable energy infrastructure. When every device can publish data and be directly addressed globally, real time monitoring and control becomes possible and more sophisticated as other parties can easily interact with it over Internet and integrate its functionality. Additionally the user is in control over which data to share, with whom and for what purpose (e.g. with the energy providers for billing), as well as which policy should be used when conditions change. In this demo we show how a Smart Home with an IPv6-equipped electricity smart meter prototype can report meter readings to cloud hosted business services, which collect readings from a number of meters, and can detect deviations from expected usage. In case of unexpected power shortage or surplus, the price is accordingly adjusted and the smart meters are informed. In the case of a price increase, it is up to the user to either pay the higher price, or to reduce her consumption (automatically based on their predefined policy). Similarly for a price drop, the user can choose to execute energy-hungry tasks. By allowing a energy gateway to control not only electricity but also other devices in the household infrastructure such as heating, the energy management can be made more efficient.
Supramolecular Chemistry of Anionic Cobalt(III) Bis(dicarbollide) and Cyclotriveratrylene in the Solid State and the Gas Phase (2000)

Um [Co(C2B9H11)2]−-Gegenionen 1 angeordnete Polymerschichten sind eines der Strukturmerkmale des zweidimensionalen Koordinationspolymers, das aus Na-1 und Cyclotriveratrylen (CTV) kristallin erhalten wurde. In Lösung bricht das [Na(CTV)]1(CF3CH2OH)0.25-Koordinationspolymer auf, und in der Gasphase lassen sich [Nan(CTV)m]n+-Cluster nachweisen, die ein oder zwei [Co(C2B9H11)]−-Ionen komplexieren können.
Prenatal diagnosis of variant late infantile neuronal ceroid lipofuscinosis (vLINCLFinnish; CLN5) (1999)

The first prenatal diagnosis of variant late infantile neuronal ceroid lipofuscinosis (vLINCL[Finnish]; CLN5) is reported. The disease belongs to the group of progressive encephalopathies in children with psycho-motor deterioration, visual failure and premature death. Neurons and several extraneural cells harbour lysosomal inclusions showing accumulation of material with histochemical characteristics of ceroid and lipofuscin. A Finnish woman with a daughter with vLINCL came for genetic counselling for her current pregnancy. Electron microscopy of a chorionic villus sample (CVS) at the 11th week of gestation did not reveal inclusions characteristic for NCL. DNA analysis showed that the fetus had inherited the major mutation, a 2 bp deletion of the CLN5 gene from the mother, and the same paternal (and maternal) haplotypes for COLAC1 and AC224 as the affected daughter. The pregnancy was terminated. Electron microscopy of the CVS of the aborted fetus at the 14th week of pregnancy showed lysosomal electron dense inclusions with straight and curved lamellar profiles consistent with vLINCL. Prenatal diagnosis of NCL-disorders (CLN1, CLN2, CLN3) can be made from CVS by demonstrating the mutations of the affected genes or by haplotype analysis using the closely linked markers in most cases. In various clinical settings the DNA diagnostics may not be possible. Demonstration of the characteristic inclusions of the placenta and fetal tissues remains a helpful adjunct in such cases.
A Z-source Inverter Based Flexible DG System with P+resonance and Repetitive Controllers for Power (2007)

In the present power systems, nonlinear loads connected at distribution level have increased immensely. This results in reduction of voltage quality for distribution level customers. Significantly, this is an outcome of the concerted action of small loads drawing nonlinear currents. However, the utility has an obligation to deliver a quality supply to consumers. Interestingly, with the increase in energy demand and penetration of renewable sources, generation units popularly known as Distributed Generators (DGs) are increasingly connected at the distribution level. Most of these sources are connected to the grid using power electronic converters. The power delivered from these sources depend on many factors like energy availability and load demand etc. In many occasions, the converters used in power conversion can be left with some excess capacity. This could be used to provide some ancillary functions of the power distribution like harmonics and unbalance mitigation etc. Moreover, some of these DG sources have large operating ranges demanding special converters with wide operating range. Being a single stage buck-boost inverter, recently proposed Z-source inverter is a good candidate for future DG systems. Considering these factors, this paper presents the controller design for a Z-source inverter based DG system to improve the power quality of distribution systems. To improve the reference tracking and to eliminate harmonics, a p+resonance and repetitive controller designed using a simple time delay is employed. When the system is running at full capacity, the proposed controller improves the quality of the injecting current. Subsequently, the duality of this internal model based control structure is exploited to improve the voltage quality at the connection point of the inverter when the system is not operated in the full power capacity. Proposed control method is tested with simulation results obtained using Matlab/Simulink and PLECS. Subsequently, it is experimentally validated using a laboratory prototype.
Comparison of Pediatric Trauma Scoring Tools That Incorporate Neurological Status for Trauma Team Activation (2023)

Level III.
Profiling Anticancer and Antioxidant Activities of Phenolic Compounds Present in Black Walnuts (Juglans nigra) Using a High-Throughput Screening Approach (2020)

Our recent studies have demonstrated multiple health-promoting benefits from black walnut kernels. These biological functions of black walnuts are likely associated with their bioactive constituents. Characterization of phenolic compounds found in black walnut could point out underexplored bioactive activities of black walnut extracts and promote the development of novel applications of black walnut and its by-products. In the present study, we assessed bioactivity profiles of phenolic compounds identified in the kernels of black walnuts using a high-throughput screening (HTS) approach. Black walnut phenolic compounds were evaluated in terms of their total antioxidant capacity, antioxidant response element (ARE) induction, and anticancer activities. The anticancer activities were identified by evaluating the effects of the phenolic compounds on the growth of the tumorigenic alveolar epithelial cells (A549) and non-tumorigenic lung fibroblast cells (MRC-5). Out of 16 phenolic compounds tested, several compounds (penta-<i>O</i>-galloyl-<i>β</i>-d-glucose, epicatechin gallate, quercetin, (-)-epicatechin, rutin, quercetin 3-<i>β</i>-d-glucoside, gallic acid, (+)-catechin, ferulic acid, syringic acid) exerted antioxidant activities that were significantly higher compared to Trolox, which was used as a control. Two phenolic compounds, penta-<i>O</i>-galloyl-<i>β</i>-d-glucose and quercetin 3-<i>β</i>-d-glucoside, exhibited antiproliferative activities against both the tumorigenic alveolar epithelial cells (A549) and non-tumorigenic lung fibroblast cells (MRC-5). The antioxidant activity of black walnut is likely driven not only by penta-<i>O</i>-galloyl-<i>β</i>-d-glucose but also by a combination of multiple phenolic compounds. Our findings suggested that black walnut extracts possibly possess anticancer activities and supported that penta-<i>O</i>-galloyl-<i>β</i>-d-glucose could be a potential bioactive agent for the cosmetic and pharmaceutical industries.
Soluble Functionalized Carbon Nanohorns (2007)

Carbon nanahorns (CNH) were functionalized following the methodology of 1,3-dipolar cycloaddition of azomethine ylides and found to form stable solutions in either organic solvents or water. The number of added functional units, in the form of pyrrolidine moieties, was calculated when a pyrene chromophore was utilized in the modification scheme. Moreover, complementary theoretical calculations revealed that reactivity enhancement is expected at locations near the conical-shaped tip of CNH, where the highest curvature and strain exist. Finally, additional organic transformation of already modified CNH was exploited by covalently linked ferrocene units.