1153 OBESITY, INFLAMMATION AND OVERACTIVE BLADDER: PRELIMINARY RESULTS FROM A PILOT STUDY OF SERUM LEPTIN AND MCP-1 LEVELS IN MEN AND WOMEN WITH AND WITHOUT OAB SYMPTOMS (2011)

You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Incontinence - Evaluation & Therapy1 Apr 20111153 OBESITY, INFLAMMATION AND OVERACTIVE BLADDER: PRELIMINARY RESULTS FROM A PILOT STUDY OF SERUM LEPTIN AND MCP-1 LEVELS IN MEN AND WOMEN WITH AND WITHOUT OAB SYMPTOMS Pradeep Tyagi, Michael Chancellor, Varant Kupelian, Andre Araujo, Raymond Rosen, and John McKinlay Pradeep TyagiPradeep Tyagi Royal oak, MI More articles by this author , Michael ChancellorMichael Chancellor Royal oak, MI More articles by this author , Varant KupelianVarant Kupelian Watertown, MA More articles by this author , Andre AraujoAndre Araujo Watertown, MA More articles by this author , Raymond RosenRaymond Rosen Watertown, MA More articles by this author , and John McKinlayJohn McKinlay Watertown, MA More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.763AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES An association between obesity and symptoms of overactive bladder (OAB) has been reported previously. Additionally, reports of elevated levels of urine-based inflammatory biomarkers in OAB cases compared to asymptomatic controls have led to the hypothesis that increased adipokine levels, consequent to adipocyte proliferation, may explain the obesity and OAB association. The objective of the present pilot study was to investigate the relationship between BMI, serum adipokine levels and symptoms of OAB in men and women. METHODS A sample of 40 men and women with and without symptoms of OAB was randomly selected from the Boston Area Community Health (BACH) Survey, a population-based study of urologic symptoms conducted among 5,503 adults age 30–79. The 40 subjects included in the present study were matched by gender, age, and OAB symptoms status. Analyses of serum adipokines, blinded to OAB status, included: Leptin, MCP1, IL-6, IL-8, NGF, TNF-a and IL-1b measured by xMAP luminex analysis using Millipore kit. RESULTS Preliminary results indicate an elevation of leptin (39.89 +/- 35.17 ng/mL and 21.20 +/- 20.90 ng/mL, respectively) and a decrease in MCP1 (0.27+/- 0.14ng/mL and 0.37+/- 0.13ng/mL) serum levels was noted in subject with OAB symptoms relative to controls. Serum levels of IL-6, IL-8, NGF, TNF-a and IL-1b were 100 fold lower than leptin and MCP-1 without any quantitative difference between the two groups. Serum leptin levels were positively correlated with BMI (r=0.59) and the slope was steeper for subjects with OAB compared to controls (Figure). CONCLUSIONS The increased levels of leptin among subjects with OAB symptoms are consistent with previous studies of elevated urinary chemokines . However, the decrease of serum MCP-1 levels in association with OAB symptoms was in contrast to elevated MCP-1 levels in urine-based studies, suggesting a discordance between serum- and urine-based tests, possibly due to the bladder as a proximate source of urinary MCP-1. Further studies including both serum and urine based testing are warranted to investigate these differences and to define the role and mechanism of action of inflammatory biomarkers in OAB symptoms. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e462-e463 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Pradeep Tyagi Royal oak, MI More articles by this author Michael Chancellor Royal oak, MI More articles by this author Varant Kupelian Watertown, MA More articles by this author Andre Araujo Watertown, MA More articles by this author Raymond Rosen Watertown, MA More articles by this author John McKinlay Watertown, MA More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...