gebhart/patrepeval huggingface dataset:
Метод выбора модели машинного обучения на основе устойчивости предикторов с применением значения Шепли (2021)

В статье рассмотрено использование вектора Шепли в регрессионном анализе как метода, снижающего дестабилизирующие воздействие мультиколлинеарности предикторов, а также его применение в интерпретации машинного обучения. Определены ограничения его применения. На основе значений Шепли предложен метод выбора стабильной модели, позволяющий стабилизировать показатели точности моделей при искажении предикторов и шумов, повышать показатели точности при снижении набора данных на классических и модернизированных ансамблевых алгоритмах. Испытания разработанного алгоритма проводились как на синтезированных, так и на общедоступных популярных DataSet для машинного обучения, с различной размерностью по количеству атрибутов и периодам наблюдений. В экспериментах наблюдался устойчивый положительный эффект, выраженный в сокращении взвешенной абсолютной процентной ошибки прогнозирования и рост данного эффекта при увеличении атрибутной размерности выборки. Предложенный алгоритм может выступать в качестве инструмента повышения эффективности ансамблевых алгоритмов машинного обучения, в том числе в высокоэффективных и высокоскоростных.
Acetylene-Terminated Polyimide Siloxanes (1987)

Siloxane-containing addition polyimides yield toughened high-temperature adhesives and matrix resins. Addition polyimide made by reaction of aromatic tetracarboxylic acid dianhydride with aromatic diamine in presence of ethynyl-substituted aromatic monoamine. Acetylene-terminated siloxane imide cured by heating to yield acetylene-terminated polyimide siloxane.
MR elastography as a method for the assessment of myocardial stiffness: Comparison with an established pressure–volume model in a left ventricular model of the heart (2009)

Magnetic resonance elastography (MRE) measurements of shear stiffness (mu) in a spherical phantom experiencing both static and cyclic pressure variations were compared to those derived from an established pressure-volume (P-V)-based model. A spherical phantom was constructed using a silicone rubber composite of 10 cm inner diameter and 1.3 cm thickness. A gradient echo MRE sequence was used to determine mu within the phantom at static and cyclic pressures ranging from 55 to 90 mmHg. Average values of mu using MRE were obtained within a region of interest and were compared to the P-V-derived estimates. Under both static and cyclic pressure conditions, the P-V- and MRE-based estimates of mu ranged from 98.2 to 155.1 kPa and 96.2 to 150.8 kPa, respectively. Correlation coefficients (R(2)) of 0.98 and 0.97 between the P-V and MRE-based estimates of shear stiffness measurements were obtained. For both static and cyclic pressures, MRE-based measures of mu agree with those derived from a P-V model, suggesting that MRE can be used as a new, noninvasive method of assessing mu in sphere-like fluid-filled organs such as the heart.
Integrated CMOS-compatible Q-Switched-Mode-Locked Laser at 1.9µm with On-Chip Artificial Saturable Absorber (2018)

We present a CMOS-compatible, Q-switched mode-locked integrated laser at 1.9µm with a compact footprint of 23.6×0.6×0.78mm, a Q-switched rate of 720kHz, a mode-locked rate of 1.2GHz, and pulse durations of 215fs.
Performance Investigation of a Nonlinear Energy Harvester With Random Vibrations and Subthreshold Deterministic Signals (2017)

In the field of energy harvesting, it has been demonstrated that under the appropriate conditions, nonlinear configurations of the harvester can provide better performance, compared with linear resonant oscillators; the performance is quantified in terms of the amount of energy extracted from environmental mechanical or seismic vibrations. In this paper, the results of investigations on a system for energy harvesting from wideband vibrations, using a nonlinear snap-through-buckling configuration and two piezoelectric actuators, placed at the stable minima of the potential energy function that underpins the dynamics of the flexible beam are presented. A nonlinear model is proposed that can describe the device behavior when it is driven by a suprathreshold deterministic signal, a wideband noise, or a subthreshold signal superimposed onto a (usually bandlimited) noise background. In the latter case, the system is seen to exhibit the so-called “stochastic resonance” behavior. The bandwidth of the nonlinear energy harvester is about 15 Hz, which is compatible with vibrational energy sources at low frequencies, e.g., a walking human. The device is seen to generate power up to 160 μW when subject to a noise limited at 15 Hz. The power is sufficient to operate a standard wireless sensor node and the conversion efficiency of the harvester is about 12%.
Meeting User Needs: Developing Field-Deployable Biodetection Systems Using a Micro-Separations Approach. (2011)

Abstract not provided.
Defects in alkaline earth titanate thin films - the conduction behavior of doped BST (2001)

Abstract The conduction behavior of doped BST thin films was determined in dependence of temperature (T) and the ambient oxygen partial pressure (PO2) by a special 4-point measurement technique. The studies covered lanthanum as donor and manganese as acceptor type doping in various concentrations as well as selected compositions of the solid solution series (Ba1-xSrx)TiO3. The external parameters were controlled by use of a YSZ solid state oxygen pump in the temperature range from 700°C to 1000°C and oxygen atmospheres between 10−20 and 1 bar. In contrast to the features of bulk materials, our investigations on thin films showed with a sharp drop and a plateau region a quite unusual conduction behavior. Because the classical defect chemical explanation fails, different approaches, which take a more complex defect structure and the dimensions into account, are proposed.
Experiment of synthetic Weyl points in optical regime (Conference Presentation) (2017)

Weyl fermions have not been found in nature as elementary particles, but they emerge as nodal points in the band structure of electronic and classical wave crystals. Novel phenomena such as Fermi arcs and chiral anomaly have fueled the interest in these topological points which are frequently perceived as monopoles in momentum space. We demonstrate that generalized Weyl points can exist in a parameter space and we report the first observation of such nodal points in one-dimensional photonic crystals in the optical range. The reflection phase inside the band gap of a truncated photonic crystal exhibits vortexes in the parameter space where the Weyl points are defined and they share the same topological charges as the Weyl points. These vortexes also guarantee the existence of interface states, the trajectory of which can be understood as “Fermi arcs” emerging from the Weyl nodes.
Serum Interferon-gamma-inducible protein 10 (CXCL10) is a predictive marker of fibrosis progression after liver transplantation for hepatitis C infection (2011)

Aims: Recurrence of liver fibrosis after liver transplantation (LT) for hepatitis C infection (HCV) is responsible for graft loss and patient mortality. Although the contribution of the immune system to fibrosis recurrence is anticipated, systematic studies evaluating immune parameters as predictive markers of allograft fibrosis are lacking. The infiltration of immune cells into the graft is governed by different chemokines including CCL2 and the CXCR3 ligands CXCL9, CXCL10 and CXCL11. We here assessed the predictive value of serum levels of these chemokines with regards to fibrosis recurrence after LT for hepatitis C infection.Material and Methods: We determined in 90 HCV infected organ recipients the serum chemokine levels of CXCL9, CXCL10, CXCL11 and CCL2 by cytometric bead assay six to nine months after LT in a clinically stable situation without acute rejection of the graft, apparent infection or novel co-morbidity and correlated them with histological fibrosis progression in protocol biopsies at years 1, 3, 5 and 7 (median follow-up 3 years). Association of chemokines with fibrosis progression was assessed by univariate and multivariate analyses and Cox regression analysis. Results: Out of the analysed chemokines, CXCL10 levels shortly after LT were strongly associated with early fibrosis regression (years 1 and 3, P=0.005), independent of the known risk factor donor age (P=0.004). Cox regression analysis confirmed the predictive value of CXCL10 with regard to progression to at least F2 or F3 fibrosis during follow-up (P&lt;0.001). A serum level of ≤ 140 pg/ml CXCL10 was significantly predictive of remaining free of F2 fibrosis (P=0.001), while ≤ 220 pg/ml CXCL10 early after LT predicted the absence of F3 fibrosis during follow-up (P=0.035). Conclusion: CXCL10 is a biomarker of fibrosis recurrence after LT for HCV infection. The results might guide patients’ care after transplantation and help to define optimal candidates for antiviral therapy post LT.
A fact-finding survey on the heat generation from processing equipment at a semiconductor fab under operation (2002)

The energy balance in vertical oxidation furnaces in a semiconductor fab under full scale operation was measured for the heat loads for cooling water, exhaust air and clean room air, which have not yet fully been reported. The results showed that the heat generated from the furnaces was removed with ratio of 64% by cooling water, 14% by exhausting air and 22% by clean room air, indicating very similar values measured in a laboratory scale operation reported by the authors at ISSM'99. Based on these results, the amount of energy saving was estimated by applying the energy saving methods proposed at ISSM'99. More than 35% of energy consumption can be reduced, which corresponds to more than 50% reduction of CO/sub 2/ release or 50% operation cost reduction compared to the current system.
Reversible and Irreversible Effects of Electroporation on Contractility and Calcium Homeostasis in Isolated Cardiac Ventricular Myocytes (2022)

Sublethal EP affected rat left ventricular myocytes contractility and disrupted Ca<sup>2+</sup> homeostasis as a function of the EP voltage. Moreover, EP-induced lethality was preceded by a large increase in intracellular Ca<sup>2+</sup> and was dependent upon the EP duration, amplitude and left ventricular myocytes orientation with respect to the electric field. These findings provide new insights into the effect of pulsed electric field on cardiac myocytes.
High DNA Affinity of a Series of Peptide Linked Diaromatic Guanidinium-like Derivatives (2012)

In this paper we report the design and synthesis of a new family of asymmetric peptide linked diaromatic dications as potent DNA minor groove binders. These peptide-linked compounds, with a linear core, displayed a much larger affinity than other guanidinium-like derivatives from the same series with curved cores. As a first screening, the DNA affinity of these structures was evaluated by means of thermal denaturation experiments, finding that the nature of the cation (guanidinium vs 2-aminoimidazolinium) significantly influenced the binding strength. Their binding affinity was assessed by implementing further biophysical measurements such as surface plasmon resonance and circular dichroism. In particular, it was observed that compounds 6, 7, and 8 displayed both a strong binding affinity and significant selectivity for AT oligonucleotides. In addition, the thermodynamics of their binding was evaluated using isothermal titration calorimetry, indicating that the binding is derived from favorable enthalpic and entropic contributions.
Treatment of Lupus Nephritis With Abatacept: The Abatacept and Cyclophosphamide Combination Efficacy and Safety Study (2014)

The addition of abatacept to a regimen of CYC followed by AZA did not improve the outcome of lupus nephritis at either 24 or 52 weeks. No worrisome safety signals were encountered.
Intranasal oxytocin fails to acutely improve glucose metabolism in obese men (2018)

The hypothalamic neuropeptide oxytocin not only modulates psychosocial function, but also contributes to metabolic regulation. We have recently shown that intranasal oxytocin acutely improves beta-cell responsivity and glucose tolerance in normal-weight men. In the present experiment, we investigated the acute glucoregulatory impact of oxytocin in obese men with impaired insulin sensitivity. Fifteen obese healthy men with an average body mass index of 35 kg/m<sup>2</sup> and an average body fat content of 33% received a single intranasal dose (24 IU) of oxytocin before undergoing an oral glucose tolerance test. Results were analysed according to the oral minimal model and compared with our findings in normal-weight participants. In contrast to the results in normal-weight subjects, oxytocin did not blunt postprandial glucose and insulin excursions in obese men, and moreover failed to enhance beta-cell responsivity and glucose tolerance. These results indicate that pronounced obesity may be associated with a certain degree of resistance to the glucoregulatory impact of exogenous oxytocin, and underlines the need for further investigations into the potential of oxytocin to improve glucose homeostasis in the clinical context.
Uplink Channel Dependent Scheduling for Future Cellular Systems (2007)

One goal in the development of future cellular systems is to increase performance. Channel dependent scheduling can possibly contribute to a performance enhancement. It requires channel qualityinformation and uplink channel knowledge is often incomplete. This master thesis work compares channel dependent scheduling and channel independent scheduling for a Single Carrier Frequency Division Multiple Access-based uplink in time domain and time and frequencydomain assuming continuous channel quality information updates. It also evaluates different methods for providing channel quality information by investigating how the limited channel knowledge they supply affects the performance of channel dependent scheduling. Single-cell simulations with perfect channel knowledge indicate small gains for channel dependent scheduling. Large gains are seen when performing frequency and time domain scheduling instead of only time domain scheduling. Limited channel knowledge causes performance loss for channel dependent scheduling. The performance is only slightly decreased if a method with sufficiently frequent providing of channel quality information updates is applied. More realistic multi-cell simulations show large gains for channel dependent scheduling. It is possible that these results are influenced by link adaptation and scheduling problems due to non predictable interference when performing dynamic scheduling. In the comparison between channel dependent and channel independent scheduling the channel dependent scheduling can benefit from the fact that the selected channel dependent scheduling algorithms result in a more static scheduling than the selected channel independent scheduling algorithms do.
Diagnostic Accuracy of 68Ga-PSMA-11 PET for Pelvic Nodal Metastasis Detection Prior to Radical Prostatectomy and Pelvic Lymph Node Dissection (2021)

ClinicalTrials.gov Identifiers: NCT03368547, NCT02611882, and NCT02919111.
Extracellular Acidic Sulfur‐Containing Amino Acids and γ‐Glutamyl Peptides in Global Ischemia: Postischemic Recovery of Neuronal Activity Is Paralleled by a Tetrodotoxin‐Sensitive Increase in Cysteine Sulfinate in the CA1 of the Rat Hippocampus (1991)

An excessive activation of the excitatory amino acid system has been proposed as one possible mediator of the ischemia-induced delayed death of CA1 pyramidal cells in the hippocampus. Using dialytrodes in the CA1 of the rat, we have investigated multiple-unit activity and extracellular changes in acidic sulfur-containing amino acids and gamma-glutamyl peptides during ischemia (20-min, four-vessel occlusion) and during 8 h of reflow. Multiple-unit activity was abolished during ischemia and for the following 1 h, but then recovered, gradually reaching preischemic levels after 8 h of reflow. Extracellular cysteate, cysteine sulfinate, and gamma-glutamyltaurine increased (1.5- to threefold) during ischemia, and extracellular glutathione and gamma-glutamylaspartate plus gamma-glutamylglutamine increased during early reflow (two- to threefold). The recovery of neuronal activity at 4-8 h was paralleled by an increase in extracellular cysteine sulfinate (2.5-fold at 8 h of reflow). Perfusion with 10 microM tetrodotoxin at 8 h of reflow abolished the multiple-unit activity and reduced extracellular cysteine sulfinate. Considering the glutamate-like properties of cysteine sulfinate, the observed postischemic increase may be involved in the development of the delayed neuronal death.
Effects of frusemide and captopril on the relationship between biologically and immunologically active renin in human plasma (1988)

1. The plasma renin concentration (PRC) and active renin concentration determined by radioimmunometric assay (ARC) were measured before and after administration of frusemide or captopril to normal volunteers. 2. Injection of 40 mg of frusemide followed by 1 h in the upright position significantly increased both PRC (P less than 0.001) and ARC (P less than 0.001). Oral administration of 50 mg of captopril also increased PRC (P less than 0.05) and ARC (P less than 0.05). 3. ARC and PRC were linearly correlated in the basal supine position [y = 0.635x - 0.048 (y = PRC, x = ARC), r = 0.958, P less than 0.001], after frusemide injection and standing (y = 0.800x + 0.359, r = 0.793, P less than 0.02) and after captopril administration in the supine position (y = 0.938x - 0.555, r = 0.998, P less than 0.001). 4. A cross-calibration study in which pure human renin was added to pooled plasma and PRC and ARC were measured showed linearity between the values obtained by the two methods. 5. The regression line for values of PRC and ARC in the supine position after captopril administration had a significantly greater slope (P less than 0.001) and that for values after frusemide injection and standing was significantly elevated (P less than 0.001) compared with the regression line for basal values in the supine position. 6. These results show that the biological activity of renin may be increased by various acute stimulations of renin to inappropriately high levels compared with the immunological activity.(ABSTRACT TRUNCATED AT 250 WORDS)
Adjustable Electrophilicity by Cooperative Hydrogen Bonds (2011)

Control of reactivity: A gradual adjustment of the electrophilicity of a barbiturate merocyanine is achievable using cooperative hydrogen bonds (see scheme). Substituent effects at the receptor are directly transmitted to the reactive center of the electrophilic substrate so that an almost infinitely variable adjustment of its reactivity is possible. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Mild cognitive impairment subcategories depend on the source of norms (2011)

The diagnosis of mild cognitive impairment (MCI) entails evidence of objective cognitive loss using neuropsychological measures. In this study, we examined whether the presence and degree of objective cognitive impairment varied according to the use of published versus local norms. We also varied the cutoff scores at which impairment was recognized and examined whether this altered inclusion in MCI subcategories. We found that the use of different comparison normative groups altered the subcategory diagnoses, especially when the cutoff score for impairment was conservative. In general, local norms were more stringent than published norms. We discuss the implications of these results for MCI diagnosis and categorization.
A bird's eye view of global methylation (2000)

Restriction landmark genomic scanning applied to a broad variety of cancer types can disclose tumour-specific and tumour-type-specific global methylation profiles. This and other genome-scanning approaches allows the rapid analysis of methylation profiles of thousands of genes in parallel-and promises to identify new genes critical to carcinogenesis and other biological processes.
Influence of ultrasonication times on the tunable colour emission of ZnO nanophosphors for lighting applications (2014)

This paper reports on the sonochemical synthesis of zinc oxide (ZnO) nanophosphors (NPr) at different ultrasonication times (5 min, 30 min, 1h, 5h, 10h and 15 h) for near white light emission applications. X-ray photoelectron spectroscopy indicated that the O1s peak consists of two components. These were O1 (ZnO) and O2 (deficient oxygen; OH groups) centred at 529.7±0.3 eV and 531.1±0.3 eV, respectively. All samples showed UV and defect level emission (DLE). The DLE enhancement was due to the increase in oxygen related defects such as oxygen vacancies/interstitials. Due to the combination of near UV and DLE near white light emission in ZnO NPr was obtained. The emission could be tuned with different ultrasonic times. It was found that the ultrasonication time influenced the growth mechanism and luminescence properties of the ZnO NPr.
Development of Continuous Recirculating Peritoneal Dialysis Using a Double Lumen Catheter (1992)

Continuous recirculating peritoneal dialysis (CRPD) was newly introduced to improve solute removal efficiency in conventional dialysis therapies such as hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD). In CRPD, a part of the dialysate in the peritoneal cavity was drained through a double-lumen catheter and purified by an extracorporeal dialyzer. Urea removal characteristics in CRPD were examined in a canine study. In this study, a recirculation-dialysis experiment using a dog weighing 9.0 kg was carried out under 100 and 200 ml/min of flow for recirculating and delivered dialysates, respectively. An FB-50H (Nipro Medical Industries, Ltd., Osaka, Japan) composed of cellulose diacetate membrane with 0.5 m2 of surface area and Dianeal-1.5 (Baxter Limited Laboratories, Tokyo, Japan) containing urea were used as the extracorporeal dialyzer and dialysate. Urea peritoneal and dialyzer dialysances (DBP and DBD) were 3.05 and 33.3 ml/min by computer simulation using a compartment model for CRPD. This DBP value can be estimated as 20.3 ml/min for a 60 kg human. From this result, time-averaged value for BUN over an 8 hr/day CRPD, combined with three exchanges/day as CAPD is estimated to be 34.3 mg/dl, which is much lower than 45.2 mg/dl for a 12 hr/week HD, or 53.0 mg/dl for conventional CAPD.