gebhart/patrepeval huggingface dataset:
An Automatic Detection and Diagnosis Framework for Mobile Communication Systems (2012)

As the complexity of commercial cellular networks grows, there is an increasing need for automated methods detecting and diagnosing cells not only in complete outage but with degraded performance as well. Root cause analysis of the detected anomalies can be tedious and currently carried out mostly manually if at all; in most practical cases, operators simply reset problematic cells. In this paper, a novel integrated detection and diagnosis framework is presented that can identify anomalies and find the most probable root cause of not only severe problems but even smaller degradations as well. Detecting an anomaly is based on monitoring radio measurements and other performance indicators and comparing them to their usual behavior captured by profiles, which are also automatically built without the need for thresholding or manual calibration. Diagnosis is based on reports of previous fault cases by identifying and learning their characteristic impact on different performance indicators. The designed framework has been evaluated with proof-of-concept simulations including artificial faults in an LTE system. Results show the feasibility of the framework for providing the correct root cause of anomalies and possibly ranking the problems by their severity.
Development and mechanistic study of a new aldehyde decarbonylation catalyst (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDevelopment and mechanistic study of a new aldehyde decarbonylation catalystFaraj Abu-Hasanayn, Martin E. Goldman, and Alan S. GoldmanCite this: J. Am. Chem. Soc. 1992, 114, 7, 2520–2524Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://pubs.acs.org/doi/10.1021/ja00033a028https://doi.org/10.1021/ja00033a028research-articleACS PublicationsRequest reuse permissionsArticle Views820Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
UWB LNAs for ground penetrating radar (2009)

Two LNA topologies for use in UWB systems are examined and compared in this paper. Design specifications have been derived from a ground penetrating radar system which is the target application. Circuits have been designed to cover the frequency range from 3.1 GHz to 10.6 GHz. The SiGe:C technology SGB25V of IHP Microelectronics is applied to enable volume production at low prices. For measurement purposes, input and output are matched to 50 Omega.
Characteristics of BRCA2 Mutated Prostate Cancer at Presentation (2022)

Genetic alterations of DNA repair genes, particularly BRCA2 in patients with prostate cancer, are associated with aggressive behavior of the disease. It has reached consensus that somatic and germline tests are necessary when treating advanced prostate cancer patients. Yet, it is unclear whether the mutations are associated with any presenting clinical features. We assessed the incidences and characteristics of <i>BRCA2</i> mutated cancers by targeted sequencing in 126 sets of advanced prostate cancer tissue sequencing data. At the time of diagnosis, cT3/4, N1 and M1 stages were 107 (85%), 54 (43%) and 35 (28%) samples, respectively. <i>BRCA2</i> alterations of clinical significance by AMP/ASCO/CAP criteria were found in 19 of 126 samples (15.1%). The <i>BRCA2</i> mutated cancer did not differ in the distributions of TNM stage, Gleason grade group or histological subtype compared to <i>BRCA2</i> wild-type cancers. Yet, they had higher tumor mutation burden, and higher frequency of <i>ATM</i> and <i>BRCA1</i> mutations (44% vs. 10%, <i>p</i> = 0.002 and 21% vs. 4%, <i>p</i> = 0.018, respectively). Of the metastatic subgroup (M1, n = 34), mean PSA was significantly lower in <i>BRCA2</i> mutated cancers than wild-type (<i>p</i> = 0.018). In the non-metastatic subgroup (M0, n = 64), PSA was not significantly different (<i>p</i> = 0.425). A similar trend was noted in multiple metastatic prostate cancer public datasets. We conclude that <i>BRCA2</i> mutated metastatic prostate cancers may present in an advanced stage with relatively low PSA.
Streptavidin–Biotin Crosslinking of Therapeutic Enzymes With Carrier Antibodies: Nanoconjugates for Protection Against Endothelial Oxidative Stress (2004)

The streptavidin-biotin system may be used to synthesize immunoconjugates for targeted delivery of drugs, including therapeutic enzymes. The size of antibody-enzyme conjugates, which is controlled by the extent of biotinylation and molar ratio between the conjugate components, represents an important parameter that in some cases dictates subcellular addressing of drugs. This chapter describes the methodology of formation and characterization of polymeric immunoconjugates in the nanoscale range. A theoretical model of streptavidin conjugation based on general principles of polymer chemistry is considered. Factors that influence size and functional characterization of resulting polymer conjugates, as well as advantages and limitations of this approach, are described in detail. The protocols describe the formation of immunoconjugates possessing an antioxidant enzyme, catalase, directed to endothelial cells by anti-platelet endothelial cell adhesion molecule antibodies. However because of the modular nature of the streptavidin-biotin crosslinker system, the techniques herein can be easily adapted for the preparation of nanoscale immunoconjugates delivering other protein drugs to diverse cellular antigens.
Achievable Rates for Multiuser Interference Relay Channel (2010)

We consider the interference relay channel (IRC) where a single relay assists the communications between multiple source-destination links under the half-duplex (HD) constraint. We assume each source has an independent message and its transmitted signal may cause interference at the other destinations. We assume each node only estimates its backward channels and has no knowledge of its forward channels as well as the other links. The role of the relay is to generate signals to cooperate with the intended signal and mitigate the interference at all destinations. Specifically, we propose coding schemes and transmission strategies for 2-user AWGN IRC with two sourcedestination pairs. We compare the performance of the proposed IRC coding schemes with that of a TDMA strategy where each source-destination pair communicates in alternative time slots with the assistance of the relay. Our simulation results based on practical turbo codes as underlying constituent codes show that the proposed transmission strategies result in a significant performance improvement over TDMA strategy in terms of outage probability and throughput.
Status of the 0.8 teraflops supercomputer at Columbia (1996)

The first stage in the construction of the 0.8 Teraflops Supercomputer at Columbia, a working, two node parallel computer, has been successfully completed. The next stage, a 512 node, 26 Gigaflops prototype, is in its final construction phase. A general description and current status of the hardware and software is presented.
SPECTROSCOPY OF HIGHLY ROTATIONALLY EXCITED Bal $C^{2}\Pi - X^{2}\Sigma^{+}$ (1989)

$^{1}$ M. A. Johnson, C. Noda, J. S. McKillop, and R. N. Zare, Can, J. Phys 62, 1467 (1984).
Modal reduction in single crystal sapphire optical fiber (2015)

A type of single crystal sapphire optical fiber (SCSF) design is proposed to reduce the number of guided modes via a highly dispersive cladding with a periodic array of high- and low-index regions in the azimuthal direction. The structure retains a “core” region of pure single crystal (SC) sapphire in the center of the fiber and a “cladding” region of alternating layers of air and SC sapphire in the azimuthal direction that is uniform in the radial direction. The modal characteristics and confinement losses of the fundamental mode were analyzed via the finite element method by varying the effective core diameter and the dimensions of the “windmill”-shaped cladding. The simulation results showed that the number of guided modes was significantly reduced in the windmill fiber design, as the radial dimension of the air and SC sapphire cladding regions increase with corresponding decrease in the azimuthal dimension. It is anticipated that the windmill SCSF will readily improve the performance of current fiber optic sensors in the harsh environment and potentially enable those that were limited by the extremely large modal volume of unclad SCSF.
Rational assembly and dual functionalization of Au@MnO heteroparticles on TiO2nanowires (2013)

Au–MnO heteroparticles were immobilized on the surface of TiO2 nanowires and tagged subsequently with a fluorescent ligand. The immobilization of the Au@MnO heteroparticles was achieved by functionalizing the TiO2 nanowire support with a polymer containing catechol anchor groups for binding to the metal oxide surface and amine groups for conjugation to the Au domains of the Au@MnO heteroparticles. The Au domain of the resulting TiO2@Au–MnO nanocomposite could be functionalized selectively with a thiol-tagged 24 mer oligomer containing Texas red (SH-ODN-TXS red), whereas a green dye (NBD–Cl) could be anchored selectively to the TiO2 “support” using the free amine groups of the polymeric ligand. The binding of the NBD and the Texas red fluorophors was monitored by confocal microscopy and the functionalization of the metal oxide nanoparticles was monitored by UV-Vis spectroscopy. All composite products were characterized by transmission electron microscopy (TEM) combined with energy dispersive X-ray spectroscopy (EDX), confocal laser scanning microscopy (CLSM) and UV-Vis spectroscopy.
Imaging androgen receptor function during flutamide treatment in the LAPC9 xenograft model (2005)

The current understanding of the response of androgen receptor to pharmacologic inhibitors in prostate cancer is derived primarily from serum prostate-specific antigen (PSA) levels. In this study, we test whether a novel androgen receptor-specific molecular imaging system is able to detect the action of the antiandrogen flutamide on androgen receptor function in xenograft models of prostate cancer. Adenoviruses bearing an optical imaging cassette containing an androgen receptor-responsive two-step transcriptional amplification system were injected into androgen-dependent and hormone-refractory tumors of animals undergoing systemic time-controlled release of the antiandrogen flutamide. Imaging of tumors with a cooled charge-coupled device camera revealed that the response of AdTSTA to flutamide is more sensitive and robust than serum PSA measurements. Flutamide inhibits the androgen signaling pathway in androgen-dependent but not refractory tumors. Analysis of androgen receptor and RNA polymerase II binding to the endogenous PSA gene by chromatin immunoprecipitation revealed that flutamide treatment and androgen withdrawal have different molecular mechanisms. The application of imaging technology to study animal models of cancer provides mechanistic insight into antiandrogen targeting of androgen receptor during disease progression.
The eXperience Methodology for Writing IS Case Studies. (2007)

Postcapillary high-endothelial venules were studied in the palatine tonsils of 48 fetuses and 19 children aged from the 10th gestational week to the end of the first year of life. Light microscopy was used to study their localization and distribution in extrafollicular lymphatic tissue in histological sections. The anlage of the venules was detected as early as in the 14th gestational week. Transmission electron microscopy was used to study the ultrastructure of high-endothelial cells and adjacent connective tissue structures of the venular wall.
Carbamazepine Is a Radioprotector and Radiation Damage Mitigator for Murine Hematopoietic Cell Line 32D Cl 3 (2010)

Abstract Abstract 4772 The search for new radiation mitigators includes targeted new- indication testing of known drugs. Carbamazepine (cbz) has been used for decades in the treatment of trigeminal neuralgia, epilepsy, mania and bipolar disorders, and has recently been demonstrated to reduce liver damage in a mouse model of alpha-1-antitrypsin deficiency by a mechanism that stimulates the proteasomal and autophagic pathway allowing degradation and clearing of abnormally folded antitrypsin. Because of its potential mitochondrial membrane ion channel effects, we tested cbz action on the irradiation survival of murine hematopoietic progenitor 32D cl 3 cells that were incubated for 1 hour in 1, 10 or 100 μ M cbz either before or after irradiation. Cells were irradiated to doses ranging from 0 to 8 Gy, plated in 4% methylcellulose, incubated for seven days at 37°C, and colonies of greater than 50 cells counted. Data was analyzed using linear quadratic or single-hit, multi-target models. Cbz added before irradiation resulted in radioprotection by an increased Do of 2.1 + 0.1 Gy (p = 0.0117), 2.3 + 0.1 Gy (p = 0.010), or 3.6 + 0.7 Gy (p = 0.0026) for 1, 10 or 100 μ M, respectively, compared to 1.5 + 0.1 Gy for control irradiated 32D cl 3 cells, with no significant change in the ñ (shoulder on the survival curve). Cbz added after irradiation mitigated against damage by an increase in the shoulder (ñ) on the survival curve with no significant change in the Do. Control irradiated 32D cl 3 cells had a ñ of 1.4 + 0.3 compared to 10.1 + 4.2 (p = 0.0113), 5.5 + 1.7 (p = 0.0185) or 3.6 + 0.8 (p = 0.0144) for cells treated after irradiation with 1, 10 or 100 μ M cbz, respectively. Cbz is known to stabilize ion channels in both cellular and mitochondrial membranes. Since irradiation induced apoptosis involves influx of calcium across the mitochondrial membrane followed by induction of nitric oxide synthase, nitric oxide and peroxynitrite formation, destabilization of the mitochondrial membrane and cytoplasmic release of cytochrome C; cbz-stabilization of mitochondrial ion channels may be the mechanism of this novel radiation mitigative effect of a commonly used drug. Supported by NIAID grant U19AI068021. Disclosures: No relevant conflicts of interest to declare.
Prevention of liver cancer cachexia-induced cardiac wasting and heart failure (2013)

Systemic effects of tumours lead not only to CC but also to cardiac wasting, associated with LV-dysfunction, fibrotic remodelling, and increased mortality. These adverse effects of the tumour on the heart and on survival can be mitigated by treatment with either the β-blocker bisoprolol or the aldosterone antagonist spironolactone. We suggest that clinical trials employing these agents be considered to attempt to limit this devastating complication of cancer.
The Most Common VHL Point Mutation R167Q in Hereditary VHL Disease Interferes with Cell Plasticity Regulation (2021)

Von Hippel-Lindau <i>disease</i> (<i>VHL</i>) is a rare hereditary syndrome due to mutations of the <i>VHL</i> tumor suppressor gene. Patients harboring the R167Q mutation of the <i>VHL</i> gene have a high risk of developing ccRCCs. We asked whether the R167Q mutation with critical aspects of pseudo-hypoxia interferes with tumor plasticity. For this purpose, we used wild-type <i>VHL</i> (WT-VHL) and VHL-R167Q reconstituted cells. We showed that WT-VHL and VHL-R167Q expression had a similar effect on cell morphology and colony formation. However, cells transfected with VHL-R167Q display an intermediate, HIF2-dependent, epithelial-mesenchymal phenotype. Using RNA sequencing, we showed that this mutation upregulates the expression of genes involved in the hypoxia pathway, indicating that such mutation is conferring an enhanced pseudo-hypoxic state. Importantly, this hypoxic state correlates with the induction of genes belonging to epithelial-mesenchymal transition (EMT) and stemness pathways, as revealed by GSEA TCGA analysis. Moreover, among these deregulated genes, we identified nine genes specifically associated with a poor patient survival in the TCGA KIRC dataset. Together, these observations support the hypothesis that a discrete VHL point mutation interferes with tumor plasticity and may impact cell behavior by exacerbating phenotypic switching. A better understanding of the role of this mutation might guide the search for more effective treatments to combat ccRCCs.
Levels of Evidence in the Urological Literature (2007)

This study suggests that a majority of studies in the urological literature provide low levels of evidence that may not be well suited to guide clinical decision making. We propose that editors of leading urology journals should promote awareness for this guiding principle of evidence based clinical practice by providing a level of evidence designation with each published study.
Extracting, Visualizing, and Learning from Dynamic Data: Perfusion in Surgical Video for Tissue Characterization (2022)

Intraoperative assessment of tissue can be guided through fluorescence imaging which involves systemic dosing with a fluorophore and subsequent examination of the tissue region of interest with a near-infrared camera. This typically involves administering indocyanine green (ICG) hours or even days before surgery and intraoperative visualization at the time predicted for steady-state signal-to-background status. Here, we describe our efforts to capture and utilize the information contained in the first few minutes after ICG administration from the perspective of both signal processing and surgical practice. We prove a method for characterization of cancerous versus benign rectal lesions now undergoing further development and validation via multicenter clinical phase studies.
SARM1 depletion rescues NMNAT1 dependent photoreceptor cell death and retinal degeneration (2020)

Abstract Leber congenital amaurosis type 9 is an autosomal recessive retinopathy caused by mutations of the NAD + synthesis enzyme NMNAT1. Despite the ubiquitous expression of NMNAT1, patients do not manifest pathologies other than retinal degeneration. Here we demonstrate that widespread NMNAT1 depletion in adult mice mirrors the human pathology, with selective loss of photoreceptors highlighting the exquisite vulnerability of these cells to NMNAT1 loss. Conditional deletion demonstrates that NMNAT1 is required within the photoreceptor. Mechanistically, loss of NMNAT1 activates the NADase SARM1, the central executioner of axon degeneration, to trigger photoreceptor death and vision loss. Hence, the essential function of NMNAT1 in photoreceptors is to inhibit SARM1, highlighting an unexpected shared mechanism between axonal degeneration and photoreceptor neurodegeneration. These results define a novel SARM1-dependent photoreceptor cell death pathway and identifies SARM1 as a therapeutic candidate for retinopathies.
Aryl amination using ligand-free Ni(II) salts and photoredox catalysis (2016)

Over the past two decades, there have been major developments in transition metal-catalyzed aminations of aryl halides to form anilines, a common structure found in drug agents, natural product isolates, and fine chemicals. Many of these approaches have enabled highly efficient and selective coupling through the design of specialized ligands, which facilitate reductive elimination from a destabilized metal center. We postulated that a general and complementary method for carbon-nitrogen bond formation could be developed through the destabilization of a metal amido complex via photoredox catalysis, thus providing an alternative approach to the use of structurally complex ligand systems. Here, we report the development of a distinct mechanistic paradigm for aryl amination using ligand-free nickel(II) salts, in which facile reductive elimination from the nickel metal center is induced via a photoredox-catalyzed electron-transfer event.
Triple-slot phase-shifting cell loaded with capacitances for reflectarray applications (2012)

This paper presents a new phase-shifting cell topology for reflectarray. It consists of a symmetrical set of three parallel rectangular slots loaded with a combination of variable and fixed capacitances to provide four uniformly-distributed phase states with a large bandwidth. Two different slot lengths are combined to improve the bandwidth. The cell is characterized in C-band using the waveguide simulation approach.
Advances in three-dimensional rapid prototyping of microfluidic devices for biological applications (2014)

The capability of 3D printing technologies for direct production of complex 3D structures in a single step has recently attracted an ever increasing interest within the field of microfluidics. Recently, ultrafast lasers have also allowed developing new methods for production of internal microfluidic channels within the bulk of glass and polymer materials by direct internal 3D laser writing. This review critically summarizes the latest advances in the production of microfluidic 3D structures by using 3D printing technologies and direct internal 3D laser writing fabrication methods. Current applications of these rapid prototyped microfluidic platforms in biology will be also discussed. These include imaging of cells and living organisms, electrochemical detection of viruses and neurotransmitters, and studies in drug transport and induced-release of adenosine triphosphate from erythrocytes.
A performance evaluation of connectionless overlay networks for ATM (2002)

Introducing the asynchronous transfer mode (ATM) causes a backwards compatibility problem, because ATM is connection-oriented whereas most of today's LANs are connectionless. Interconnection can be achieved by the use of connectionless servers (CLS). These servers together with a number of preestablished virtual circuits form a connectionless overlay network on top of ATM. In this paper we evaluate overlay networks that differ in number location and interconnection of CLSs by computation of mean cell delay and link load.