gebhart/patrepeval huggingface dataset:
High RDW as a predictive and prognostic factor in patients with diffuse large B-cell lymphoma treated with chemoimmunotherapy. (2018)

e19547 Background: Red blood cell distribution width (RDW) has emerged as a potential prognostic factor in diffuse large B-cell lymphoma (DLBCL) and a reliable and easy-to-use predictive tool. Methods: We performed a retrospective study on consecutive patients with a de novo diagnosis of DLBCL treated at our institution between 2010 and 2012. All patients included were treated with chemotherapy or chemoinmunotherapy with a curative intent. RDW > 14.6% was our cut-off. We fitted logistic regression models and Cox proportional-hazard regression models. Results: 121 patients with de novo DLBCL were included. Eighty patients (66%) had age ≥60 years, 54 patients (45%) were men, 41 patients (34%) had ECOG ≥2, 70 patients (58%) had increased LDH levels, 69 patients (57%) had > 1 extranodal site, 49 patients (41%) had stage III/IV disease, and 72 patients (60%) had B symptoms. Patients with high RDW (45 patients, 39%) were more likely to have ECOG ≥2 (53% vs. 21%; p < 0.001), elevated LDH levels (77% vs. 46%, p = 0.001), stage III/IV (53% vs. 34%; p = 0.04) and presence of B symptoms (54% vs. 18%; p < 0.001). Patients with high RDW also had higher IPI score (59% vs. 24%; p < 0.001) and also higher NCCN-IPI scores (53% vs. 21%, p < 0.001). They were less likely to achieve CR to therapy (48% vs. 83%; p < 0.001). In the multivariate logistic regression analyses, high RDW was a strong predictor of not achieving CR (OR 0.25, 95% CI 0.10-0.66; p = 0.005). With a median follow-up time of 5.6 years, the 5-year OS rate for patients with high RDW was 51% (95% CI 36-65%) versus 79% (95% CI 68-87%) in patients with normal RDW (p = 0.001). In the univariate Cox regression analysis, high RDW was associated with HR 2.63 (95% CI 1.41-4.89; p = 0.002). In the multivariate Cox regression analyses, high RDW was a stronger predictor of poor survival (HR 1.92, 95% CI 0.99-3.73; p = 0.05) than the IPI score (HR 1.34, 95% CI 0.58-3.11; p = 0.49) and the NCCN-IPI score (HR 2.21, 95% CI 0.87-5.59; p = 0.09). Conclusions: High RDW appears to be an adverse predictor of response and survival in patients with de novo DLBCL treated with R-CHOP, independent of the IPI and NCCN-IPI scores.
An Approach to the Site-Selective Diversification of Apoptolidin A with Peptide-Based Catalysts (2009)

We report the application of peptide-based catalysts to the site-selective modification of apoptolidin A (1), an agent that displays remarkable selectivity for inducing apoptosis in E1A-transformed cell lines. Key to the approach was the development of an assay suitable for the screening of dozens of catalysts in parallel reactions that could be conducted using only microgram quantities of the starting material. Employing this assay, catalysts (e.g., 11 and ent-11) were identified that afforded unique product distributions, distinct from the product mixtures produced when a simple catalyst (N,N-dimethyl-4-aminopyridine (10)) was employed. Preparative reactions were then carried out with the preferred catalysts so that unique, homogeneous apoptolidin analogues could be isolated and characterized. From these studies, three new apoptolidin analogues were obtained (12-14), each differing from the other in either the location of acyl group substituents or the number of acetate groups appended to the natural product scaffold. Biological evaluation of the new apoptolidin analogues was then conducted using growth inhibition assays based on the H292 human lung carcinoma cell line. The new analogues exhibited activities comparable to apoptolidin A.
Conductivity Improvements of Atomic Layer Deposited Ta3N5 (2013)

Using TaCl 5 as a precursor for thermal ALD of TaN results in an orthorhombic phase of Ta 3 N 5 which is considered as a dielectric material. Conductivity of this film is found to depend on deposition and annealing temperature, which also modifies the X-ray diffraction spectrum. Both changes are induced by lowering the N:Ta ratio which adds new diffraction peaks. This modification is stronger when annealing is performed with TaN films covered by Al. This treatment makes Ta 3 N 5 as attractive as metallic phase, δ-TaN to be used in work function metal stacks with Al contacts.
Drug Mimic Induced Conformational Changes in Model Polymer−Drug Conjugates Characterized by Small-Angle Neutron Scattering (2010)

Copolymers based on poly(N-(2-hydroxypropylmethacrylamide)) with conjugated Doxrubicin are established as candidate anticancer therapeutics. Two HPMA-co-polymers (ca. 35000 g mol(-1)) with 2.5 and 8 mol % gly-phe-leu-gly peptidyl side-chain content have been modified using linear hydrocarbon and small aromatic molecules as simple drug mimics. This first contrast-variation SANS study on these systems demonstrates, combined with detailed modeling, a controlled switch from random coil to a more defined morphology induced by inclusion of a series of model drug mimics. Relatively small changes in drug-mimic type and loading can significantly alter the solution conformation, and we tentatively propose a helical type structure that is more or less tightly wound, depending on both hydrophobe loading and type. The results presented have important implications for understanding the influence of conjugate structure on solution properties, which is an important factor influencing biological and clinical activity.
Dynamic Analysis and Applied Technology in New Anti-Jamming Hydraulic System with Fast Response (2014)

In order to avoid the jamming problem of drill-rod because of slow response of existing drilling equipment when facing gaps and karst caves during drilling process, we proposed the principle scheme of a quick-response hydraulic control system which aimed at making the jackdrill return as soon as possible once detected gaps and karst caves. The model of the hydraulic system was established and then solved by AMEsim. The parameters of critical parts such as restrictors and anti-jamming group valve were optimized by simulating to achieving the shortest theoretical response time. The system has been applied to field experiment and the result shows its ascendant ability of preventing jamming failure,the response time is shorter than traditional system in half. This research has great engineering application value to improve the drilling efficiency.
Evaluation of Hardness and Fracture Toughness of Feldspathic Porcelain by Various Surface Finishing Techniques (2022)

Introduction: Dental porcelain is fired at a high temperature inside the furnace and subsequently glazed for intraoral use as a restoration. There is no clarity on the correlation between physical properties of porcelain and its surface finishing techniques. Aim: To evaluate surface hardness and fracture toughness of feldspathic porcelain with different porcelain surface finishing methods. Materials and Methods: This in-vitro descriptive study was conducted between November 2018 and August 2019 at Department of Prosthodontics, Ragas Dental College and Hospital with 40 samples of Nickel Chrome (Ni Cr) alloy specimens, with addition of porcelain. The sample were divided into four groups S1: Unpolished, S2: Polished, S3: Autoglazed, S4: Add-on glaze according to the finishing procedures used with each group containing ten samples. All samples were tested for surface hardness and Fracture toughness and were subjected to One way ANOVA, Bonferroni posthoc tests and Statistical Package of the Social Sciences (SPSS) California, USA. Results: Mean value of fracture toughness (in MPa1/2) for 0.2 kg load was 0.729672 for S1, 1.187567 for S2, 0.89482 for S3, 1.324399 for S4. Mean value of surface hardness (in kg/mm2 ) for 1 kg load was 360.048 for S1, 519.166 for S2, 508.817 for S3, 527.916 for S4. Maximum deviation of 24.752 and error of 7.8273 was found in S4, least deviation of 10.77 and error of 3.4077 was found in S1 group. Conclusion: The glazed porcelain had the highest micro hardness and fracture toughness followed by polished porcelain and autoglazed porcelain.
A parallel architecture of interpolated timing recovery for high- speed data transfer rate and wide capture-range (2007)

High data transfer rate has been demanded for data storage devices along increasing the storage capacity. In order to increase the transfer rate, high-speed data processing techniques in read-channel devices are required. Generally, parallel architecture is utilized for the high-speed digital processing. We have developed a new architecture of Interpolated Timing Recovery (ITR) to achieve high-speed data transfer rate and wide capture-range in read-channel devices for the information storage channels. It facilitates the parallel implementation on large-scale-integration (LSI) devices.
Jet energy scale and resolution in the CMS experiment in pp collisions at 8 TeV (2017)

Improved jet energy scale corrections, based on a data sample corresponding to an integrated luminosity of 19.7 fb$^{-1}$ collected by the CMS experiment in proton-proton collisions at a center-of-mass energy of 8 TeV, are presented. The corrections as a function of pseudorapidity η and transverse momentum p(T) are extracted from data and simulated events combining several channels and methods. They account successively for the effects of pileup, uniformity of the detector response, and residual data-simulation jet energy scale differences. Further corrections, depending on the jet flavor and distance parameter (jet size) R, are also presented. The jet energy resolution is measured in data and simulated events and is studied as a function of pileup, jet size, and jet flavor. Typical jet energy resolutions at the central rapidities are 15–20% at 30 GeV, about 10% at 100 GeV, and 5% at 1 TeV. The studies exploit events with dijet topology, as well as photon+jet, Z+jet and multijet events. Several new techniques are used to account for the various sources of jet energy scale corrections, and a full set of uncertainties, and their correlations, are provided.The final uncertainties on the jet energy scale are below 3% across the phase space considered by most analyses ($p_T$ &gt; 30 GeV and 0| η| &lt; 5.0). In the barrel region (| η| &lt;1.3) an uncertainty below 1% for $p_T$ &gt; 30 GeV is reached, when excluding the jet flavor uncertainties, which are provided separately for different jet flavors. A new benchmark for jet energy scale determination at hadron colliders is achieved with 0.32% uncertainty for jets with $p_T$ of the order of 165–330 GeV, and | η| &lt;0.8.
Wireless Fingerprinting via Deep Learning: The Impact of Confounding Factors (2020)

Can we distinguish between two wireless transmitters sending exactly the same message, using the same protocol? The opportunity for doing so arises due to subtle nonlinear variations across transmitters, even those made by the same manufacturer. Since these effects are difficult to model explicitly, we investigate learning device fingerprints using complex-valued deep neural networks (DNNs) that take as input the complex baseband signal at the receiver. We ask whether such fingerprints can be made robust to distribution shifts across time and locations due to clock drift and variations in the wireless channel. In this paper, we point out that, unless proactively discouraged from doing so, DNNs learn these strong confounding features rather than the nonlinear device-specific characteristics that we seek to learn. We propose and evaluate strategies, based on augmentation and estimation, to promote generalization across realizations of these confounding factors, using data from WiFi and ADS-B protocols. We conclude that, while DNN training has the advantage of not requiring explicit signal models, significant modeling insights are required to focus the learning on the effects we wish to capture.
Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation (2016)

TDP-43 is a protein that forms aggregates implicated in amyotrophic lateral sclerosis. In response to a recent study, this Formal Comment argues that the pH-dependent solubility of this protein is better explained by the mutual repulsion of charged groups than by the formation of hydrogen bonds.
NVS-MonoDepth: Improving Monocular Depth Prediction with Novel View Synthesis (2021)

Building upon the recent progress in novel view synthesis, we propose its application to improve monocular depth estimation. In particular, we propose a novel training method split in three main steps. First, the prediction results of a monocular depth network are warped to an additional view point. Second, we apply an additional image synthesis network, which corrects and improves the quality of the warped RGB image. The output of this network is required to look as similar as possible to the ground-truth view by minimizing the pixel-wise RGB reconstruction error. Third, we reapply the same monocular depth estimation onto the synthesized second view point and ensure that the depth predictions are consistent with the associated ground truth depth. Experimental results prove that our method achieves state-of-the-art or comparable performance on the KITTI and NYU-Depth-v2 datasets with a lightweight and simple vanilla U-Net architecture.
Narrowband Guided Fano Resonators for Mid-Infrared Spectroscopy and Imaging (2014)

We report the demonstration of an array of high-performance one-layer narrowband mid-IR guided Fano resonators (GFRs) in the C-H stretching region (2700−3200 cm−1) for high-quality microspectroscopic mid-IR imaging.
Mesoscopic Free Path of Nonthermalized Photogenerated Carriers in a Ferroelectric Insulator (2017)

We show how finite-size scaling of a bulk photovoltaic effect-generated electric field in epitaxial ferroelectric insulating BaTiO_{3}(001) films and a photo-Hall response involving the bulk photovoltaic current reveal a large room-temperature mean free path of photogenerated nonthermalized electrons. Experimental determination of mesoscopic ballistic optically generated carrier transport opens a new paradigm for hot electron-based solar energy conversion, and for facile control of ballistic transport distinct from existing low-dimensional semiconductor interfaces, surfaces, layers, or other structures.
Energy metabolism in late preimplantation rat embryos (1991)

The consumption of pyruvate and glucose, and the production of lactate, by single preimplantation embryos, was measured using a noninvasive technique. Embryos were cultured in 300-500-nl microdrops, for 8-12 h at a time, from Day 4 to Day 6 after mating, when they developed from the 8-cell stage to expanded blastocyst. Pyruvate was the predominant substrate at the 8-cell/morula stage; glucose uptake exceeded that of pyruvate after the onset of blastocoel formation. Lactate production increased in parallel with glucose consumption. For most stages, approximately 100% of the glucose uptake was accountable for by lactate production and in some cases an additional source of lactate must be postulated. Culture in vitro had little effect on lactate production, although a lower level of metabolism was observed compared with fresh blastocysts. Rat embryos were capable of developing to blastocysts in the absence of glucose, when lactate production was greatly reduced.
Directed self-assembly of nanoparticles for novel electrical interconnects (2012)

Future 3D chip stacks and high bandwidth flip-chip-onboard applications require advanced packaging processes that support high density electrical interconnects at a high reliability. This paper discusses the directed self-assembly of silver nanoparticles by capillary-bridging, resulting in electrical joints — so called “necks”. The necks are achieved by the evaporation of an injected nanosuspension between the chip and a carrier. A subsequent annealing step achieves high electrical conductivity and mechanical integrity. The evolution of capillary-bridges was observed in an array of copper pillars with partially depopulated areas. The meniscus penetrates these zones first, as they allow for larger curvature radii compared to fully populated zones. Initial individual necks form once all liquid has evaporated in the depopulated areas. The electrical resistance and morphology of silver nanoparticle agglomerations was studied at annealing temperatures of 60°C to 200°C by Kelvin probes, atomic force microscopy and X-ray diffractometry. A significant improvement in electrical conductivity of the film was observed above annealing temperatures of 150°C for 80 min and correlated with an increased average grain size. An in-situ characterization method, to investigate the evolution of individual capillary-bridges and the formation of electrical conducting necks is presented. A dedicated Kelvin probe measurement could track the neck formation process and shows a drop of electrical resistance of more than five orders of magnitude within 10 min from evaporation onset. Finally, silver interconnects were formed at low temperature between copper pillars and respective pads. Their shear strength identified by die shear testing was 16 MPa.
EXAFS Study of Cation Distribution in Nickel Aluminate Ferrites (1991)

A new method for analyzing the cation distribution of spinel crystals by extended X‐ray absorption fine‐structure spectroscopy has been developed to overcome the disadvantage of X‐ray diffraction, which cannot readily distinguish among different transition‐metal ions. EXAFS analysis was conducted on Ni 2+ and Fe 3+ ions in nickel aluminate ferrites, and the cation distributions obtained were in good agreement with values obtained by other methods. The ratio of tetrahedral sites occupied by Ni 2+ ions decreases with increasing iron content. Fe 3+ ions distribute nearly equally to both tetrahedral and octahedral sites. Apparently, not only crystal‐field stabilization energy but also ion size affects cation distribution.
Efficient Particle Volume Splatting in a Ray Tracer (2019)

Rendering of particle data sets is a common problem in many domains including games, film, and scientific visualization. Conventionally, this has been accomplished using rasterization-based splatting methods, which scale linearly with respect to problem size. Given sufficiently low-cost ray traversal with logarithmic complexity, splatting within a ray tracing framework could scale better to larger geometry. In this chapter, we provide a method for efficiently rendering larger particle data, exploiting ray coherence and leveraging hardware-accelerated traversal on architectures such as the NVIDIA RTX 2080 Ti (Turing) GPUs with RT Cores technology.
Synthesis, characterization, and cure chemistry of high performance phosphate cyanate ester resins (2015)

Three thermosetting cyanate ester resins with phosphate cores and potential fire-resistant applications have been synthesized and characterized. A trifunctional resin studied in this work (<bold>PhosCy3</bold>) has a <italic>T</italic><sub>g</sub> &gt; 360 °C and a char yield of 67% in air.
Volumetric Measurements of Brain Shift Using Intraoperative Cone-Beam Computed Tomography (2015)

Contrast-enhanced cone-beam computed tomography provides a feasible technique for intraoperatively determining brain shift deformation vector fields. This technique can be used perioperatively to adjust preoperative planning and coregistration during neurosurgical procedures.
Parameter Modeling for Nanopore Ionic Field Effect Transistors in 3-D Device Simulation (2014)

An Ion Field Effect Transistor (IFET) with nanopore structure was modeled in a conventional 3-dimensional (3-D) device simulator to understand current-voltage (I-V) characteristics and underlying physics of the device. Since the nanopore was filled with positive ions (K+) ions due to the negative interface charge on the insulator surface and negative gate bias condition, we could successfully simulate the IFET structure using modified p-type silicon to mimic KCl solution. We used p-type silicon with a doping concentration of 6.022 x 10(16) cm(-3) which has the same concentration of positive carriers (hole) as in 10(-4) M KCl. By controlling gate electric field effect on the mobility, the I-V curves obtained by the parameter modeling matched very well with the measured data. In addition, the decrease of [V(th)] with increasing V(DS) was physically analyzed.
Call for Papers: Strategies and Tactics in CNS Drug Synthesis (2019)

ADVERTISEMENT RETURN TO ISSUEPREVEditorialNEXTCall for Papers: Strategies and Tactics in CNS Drug SynthesisCraig W. LindsleyCraig W. LindsleyMore by Craig W. Lindsleyhttp://orcid.org/0000-0003-0168-1445Cite this: ACS Chem. Neurosci. 2019, 10, 3, 1116Publication Date (Web):March 20, 2019Publication History Published online20 March 2019Published inissue 20 March 2019https://pubs.acs.org/doi/10.1021/acschemneuro.9b00114https://doi.org/10.1021/acschemneuro.9b00114editorialACS PublicationsCopyright © 2019 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views936Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (2 MB) Get e-AlertscloseSUBJECTS:Chemical neuroscience,Chemical synthesis,Organic synthesis,Pharmaceuticals Get e-Alerts
Helicase-Like Transcription Factor HLTF and E3 Ubiquitin Ligase SHPRH Confer DNA Damage Tolerance through Direct Interactions with Proliferating Cell Nuclear Antigen (PCNA) (2020)

To prevent replication fork collapse and genome instability under replicative stress, DNA damage tolerance (DDT) mechanisms have evolved. The RAD5 homologs, HLTF (helicase-like transcription factor) and SHPRH (SNF2, histone-linker, PHD and RING finger domain-containing helicase), both ubiquitin ligases, are involved in several DDT mechanisms; DNA translesion synthesis (TLS), fork reversal/remodeling and template switch (TS). Here we show that these two human RAD5 homologs contain functional APIM PCNA interacting motifs. Our results show that both the role of HLTF in TLS in HLTF overexpressing cells, and nuclear localization of SHPRH, are dependent on interaction of HLTF and SHPRH with PCNA. Additionally, we detected multiple changes in the mutation spectra when APIM in overexpressed HLTF or SHPRH were mutated compared to overexpressed wild type proteins. In plasmids from cells overexpressing the APIM mutant version of HLTF, we observed a decrease in C to T transitions, the most common mutation caused by UV irradiation, and an increase in mutations on the transcribed strand. These results strongly suggest that direct binding of HLTF and SHPRH to PCNA is vital for their function in DDT.