gebhart/patrepeval huggingface dataset:
Sarcoïdose ou réaction granulomateuse à une surcharge métallique : à propos de trois cas (2014)

Le plomb est l’un des métaux les plus anciennement et les plus largement utilisés par l’homme. Sa toxicité est connue depuis l’Antiquité et elle est toujours d’actualité : les expositions professionnelles au plomb restent très fréquentes ; la libération d’écailles ou de poussières par la peinture de revêtements muraux anciens et mal entretenus est la source de nombreux cas de saturnisme infantile, dans divers pays, dont la France ; dans les zones où l’eau distribuée est faiblement minéralisée, elle peut être agressive pour le système d’adduction et se charger en différents métaux, dont le plomb… Cette mise au point décrit les intoxications par les dérivés inorganiques et organiques du plomb : les sources et les modalités des expositions, la toxicocinétique du plomb, les effets toxiques aigus et chroniques y compris la cancérogénicité et les effets sur la reproduction, les modalités du dépistage, du diagnostic, du traitement et du suivi du saturnisme infantile, les principes de la surveillance médicale des travailleurs exposés au plomb, du traitement et de l’indemnisation des intoxications professionnelles.The mining of lead-containing ores began in antiquity; this metal has more uses than any other one. The toxic effects of lead have also been described very early in history, and lead poisoning remains a problem in most countries: occupational exposure is frequent; children poisoning from paint chips or dust is pandemic in some developed countries including France and the USA; in areas where poorly mineralised drinking-water is distributed, lead can leach from water pipes and solder… This paper describes the poisonings due to inorganic and organic lead compounds: mains sources of these substances and circumstances of poisoning, toxicokinetics and toxic effects of lead including carcinogenicity, reproductive and developmental effects, organisation of the screening, diagnosis and medical management of lead poisoning in young children, and the principles of medical surveillance of occupational lead exposure.
A proposal for gps-less location detection using a reference direction information sharing method with co-operation of mobile terminals (2008)

This paper describes a proposal for wireless communication system and mobile terminals, especially useful for location based service without using GPS receiver in the service area. The Global Positioning System (GPS) or gyroscope sensor (gyrocompass) terminals are known as a technology to provide location information. However, GPS may not provide enough accuracy in a building, an underground complex or downtown area among high buildings. In this proposed wireless communication system, mobile terminals can obtain reference direction information and share the reference direction information at same time. This is achieved by having mobile terminals sharing signals received from reference stations installed in the service area to other mobile terminals. The proposed wireless communication system can be expected to provide advanced service using location/direction information.
Carbon-hydrogen bond activation and carbon-carbon bond formation in the reaction between ethylene and hexaisopropoxyditungsten (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon-hydrogen bond activation and carbon-carbon bond formation in the reaction between ethylene and hexaisopropoxyditungstenMalcolm H. Chisholm and Mark Hampden-SmithCite this: J. Am. Chem. Soc. 1987, 109, 19, 5871–5872Publication Date (Print):September 1, 1987Publication History Published online1 May 2002Published inissue 1 September 1987https://doi.org/10.1021/ja00253a061RIGHTS & PERMISSIONSArticle Views72Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (309 KB) Get e-Alerts Get e-Alerts
Lotus (2022)

This paper revisits the H-Store/VoltDB concurrency control scheme for partitioned main-memory databases, which we term run-to-completion-single-thread (RCST), with an eye toward improving its poor performance on multi-partition (MP) workloads. The original scheme focused on maximizing single partition (SP) performance, producing results in millions of transactions per second on modest clusters, but at the expense of dismal MP performance. In this paper, we show that original RCST algorithms be made to dramatically improve MP performance with very limited impact on SP performance. That makes RCST superior to popular optimistic and pessimistic schemes without optimizations for batch execution, including OCC and 2PL, on a wide range of multi-node workloads with up to 60% throughput improvement. Our second contribution is to propose a multiplexed-execution-single-thread (MEST) algorithm based on RCST to amortize the network stalls from MP transactions over a batch of MP transactions. This scheme delivers up to 21X higher throughput for SP transactions and comparable MP throughput compared to state-of-the-art distributed deterministic concurrency control algorithms that are optimized for batch execution. Finally, our MEST scheme offers dramatically superior performance when straggler transactions are present in the workload. Our conclusion is that the H-Store/VoltDB concurrency control scheme can be dramatically improved and dominates state-of-the-art algorithms over a variety of MP workloads.
EEG-based spatio-temporal relation signatures for the diagnosis of depression and schizophrenia (2023)

The diagnosis of psychiatric disorders is currently based on a clinical and psychiatric examination (intake). Ancillary tests are used minimally or only to exclude other disorders. Here, we demonstrate a novel mathematical approach based on the field of p-adic numbers and using electroencephalograms (EEGs) to identify and differentiate patients with schizophrenia and depression from healthy controls. This novel approach examines spatio-temporal relations of single EEG electrode signals and characterizes the topological structure of these relations in the individual patient. Our results indicate that the relational topological structures, characterized by either the personal universal dendrographic hologram (DH) signature (PUDHS) or personal block DH signature (PBDHS), form a unique range for each group of patients, with impressive correspondence to the clinical condition. This newly developed approach results in an individual patient signature calculated from the spatio-temporal relations of EEG electrodes signals and might help the clinician with a new objective tool for the diagnosis of a multitude of psychiatric disorders.
Rates of Infection After Spine Surgery Based on 108,419 Procedures (2010)

Our data suggest that postsurgical infection, even among skilled spine surgeons, is an inherent potential complication. These data provide general benchmarks of infection rates as a basis for ongoing efforts to improve safety of care.
An FPGA-based Search Engine for Unstructured Database (2003)

We present an FPGA-based search engine that implements the Smith-Waterman local sequence alignment algorithm to search a stream of input data for patterns up to 38 bytes long. This engine supports the sequence gap, match, and mismatch weightings necessary for genome sequence alignment, and it can perform inexact string matching on generic text. As the engine simply processes input data streaming through it, it can readily operate on data that are unindexed and unsorted, i.e., on unstructured databases. Furthermore, the engine can sustain a search throughput of 100 MB/sec , making it capable of processing input data at the maximum sustained throughput of the hard drive (or array of drives) storing the data. For a performance demonstration we compare the throughput of the engine embedded in a prototype system with the execution times of a direct software implementation of the search engine’s kernel. Although the prototype system limits the input data to 40.5MB/sec, we show how parallelism and pipelining allow this FPGA-based search engine to sustain a search throughput of 100 MB/sec, given a fast enough method for delivering input data, and thereby yield a performance gain over the software implementation of two orders of magnitude.
Targeting of VEGF‐dependent transendothelial migration of cancer cells by bevacizumab (2010)

Cancer progression is often associated with the formation of malignant effusions. Vascular endothelial growth factor (VEGF) is a major regulator of vascular permeability and has been implicated as mediator of tumor progression. We examined the production and secretion of VEGF(165) in various primary cancer cells derived from malignant effusions, and the role of exogenous VEGF(165) as a mediator of effusion formation. VEGF(165) was constantly secreted by all cultured tumor cells in an mTOR-dependent manner, as it was inhibited by the mTOR inhibitor rapamycin. Secreted VEGF(165) showed functional activity by inducing endothelial leakiness and tumor cell-transendothelial migration in vitro, effects which could be reverted by the anti-VEGF antibody bevacizumab. Thus, mTOR inhibitors as well as bevacizumab should be considered as potential agents in cancer patients suffering from malignant effusions.
THE EFFECTS OF MESH BIOPROSTHESIS ON THE SPERMATIC CORD STRUCTURES: A PRELIMINARY REPORT IN A CANINE MODEL (1999)

Half of the testicles had gross abnormalities after mesh repair versus none in the control and Shouldice dogs. Although all vasograms were patent, vasal luminal size was significantly decreased with a marked soft tissue foreign body reaction identified after mesh repair. A traumatic neuroma was identified suggesting nerve entrapment in the fibrotic mesh reaction, which may account for post-operative pain seen in some patients. Marlex mesh may adversely affect spermatic cord structure and function and further work is required to fully elucidate its effects.
IEEE Journal on Exploratory Solid-State Computational Devices and Circuits—Vol. 4, No. 1 (2018)

Welcome to the fourth volume, first semiannual issue of the IEEE Journal on Exploratory Solid-State Computational Devices and Circuits (JXCDC), a multidisciplinary, Open Access IEEE Journal that is focused on publishing seminal research in the exploration for energy-efficient computing based on physics and materials to enable new devices, circuits, and architecture that will be of great interest to integrated circuit researchers and those working in the IT industry. The papers in the journal are selectively chosen to provide insight into the architectural, circuit, and device implications of emerging quantum nanoelectronic and nanomagnetic device technologies. Discovery of new materials, devices, and circuits for energy-efficient computational circuits will be needed to enable Moore’s law to continue for computing beyond the end of the roadmap for CMOS technologies, by enabling a significant improvement in energy efficiency and cost per function.
Crystal engineering of brominated tectons: N-methyl-3,5-dibromo-pyridinium iodide gives particularly short C–Br⋯I halogen bonding (2004)

The crystal matrix of N-methyl-3,5-dibromopyridinium iodide is constituted of infinite helices where the cation and the anion alternate and are bound by the second shortest reported C–Br⋯I halogen bonding. The electron poor pyridinium scaffold is particularly effective in boosting the electron acceptor ability of bromine substituents.
The Role of NF-κB in Muscular Dystrophy (2013)

Aberrant activation of the nuclear factor−kappa B (NF-κB) pathway is associated with the fatal genetic muscle disease, Duchenne muscular dystrophy (DMD). NF-κB has been identified as a key player in the negative effects of chronic inflammation, which characterizes dystrophic skeletal muscle. This includes the suppression of myogenesis, which leads to decreased muscle regeneration and the exacerbation of muscular dystrophy. Several hypotheses have been proposed to explain the upregulation of NF-κB activity, and although differing significantly, they all point to the classical activation pathway, regulated by the inhibitor of kappa-B kinase (IKK). The dystrophic phenotype has been found to be significantly improved in transgenic dystrophic (mdx) mice with lowered NF-κB activity. Furthermore, several pharmacologic strategies of NF-κB blockade have demonstrated efficacy in DMD animal models, suggesting that this pathway has the potential to be a therapeutic target in human DMD patients.
Front Matter: Volume 10114 (2017)

This PDF file contains the front matter associated with SPIE Proceedings Volume 10114, including the Title Page, Copyright information, Table of Contents, Introduction (if any), and Conference Committee listing.
Improvement of Surface Tension Model and Numerical Investigation on Droplet Wetting Effect (2012)

An improved surface tension model was obtained by optimizing the position of the extreme point.The particle clustering and shape distortion problems were solved by the model improved.The moving particle semi-implicit(MPS) method combined with the improved model was adopted to simulate the wetting phenomenon with large deformation of the free surface.The shrinkage and wetting effect,due to the surface tension,between different substances(gas-liquid,solid-liquid or liquid-liquid) was examined and analyzed.The wetting angle and wetting area were extracted for analysis.The numerical result agrees well with the analytical one.Three sections could be observed in the liquid-solid wetting process.The wetting speed decreases with an increase in time and varies inversely with the wetting angle.Our results indicate that the MPS method combined with the improved surface tension model can simulate the interface tension force between different substances effectively and precisely.
Rational Control of Polymer Molecular Weight and Dispersity during Enzyme-Catalyzed Polyester Synthesis in Supercritical Fluids (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRational Control of Polymer Molecular Weight and Dispersity during Enzyme-Catalyzed Polyester Synthesis in Supercritical FluidsApurva Chaudhary, Eric J. Beckman, and Alan J. RussellCite this: J. Am. Chem. Soc. 1995, 117, 13, 3728–3733Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April 1995https://pubs.acs.org/doi/10.1021/ja00118a009https://doi.org/10.1021/ja00118a009research-articleACS PublicationsRequest reuse permissionsArticle Views542Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplemental Table 2 from New DNA Methylation Markers for Pancreatic Cancer: Discovery, Tissue Validation, and Pilot Testing in Pancreatic Juice (2023)

&lt;p&gt;Supplemental Table 2. Comparison to ICGC array data&lt;/p&gt;
Synthesis and Biological Evaluation of Thiazole-based Fibroblast Growth Factor Receptor-1 Inhibitors (2022)

The 2-aryl-5-methylthiazole linked to a basic head is a novel chemical scaffold of ATP-competitive inhibitor of FGFR-1 with potential therapeutic activities against different types of cancer.
Positive modulation of cerebellar α6GABA A receptors for treating essential tremor: a proof-of-concept study in harmaline-treated mice (2021)

Abstract Background The etiology of essential tremor (ET) remains unclear but may involve abnormal firing of Purkinje cells, which receive excitatory inputs from granule cells in the cerebellum. Since α6 subunit-containing GABA A receptors (α6GABA A Rs) are abundantly expressed in granule cells, we validated a hypothesis that α6GABA A R-selective positive allosteric modulators (PAMs) are promising pharmacological interventions for ET therapy. Methods Employing the harmaline-induced ET model in male ICR mice, we evaluated the possible anti-tremor effects of four α6GABA A R-selective PAMs, the pyrazoloquinolinones Compound 6 and LAU-463 and their respective deuterated derivatives. Propranolol, a clinical anti-tremor agent, was employed as positive control. To investigate the involvement of cerebellar α6GABA A Rs in the antitremor effect of intraperitoneal ( i.p. ) Compound 6, furosemide, an α6GABA A R antagonist, was intracerebellarly ( i.cb. ) co-administered with Compound 6. The burrowing activity, an indicator of wellbeing in rodents, was measured concurrently. Results Harmaline (10-30 mg/kg, s.c. ) induced action tremor in ICR mice dose-dependently and markedly reduced their burrowing activity. Compound 6 (3 and 10 mg/kg, i.p. ) significantly attenuated harmaline (20 mg/kg)-induced action tremor and burrowing activity impairment. Propranolol (20 mg/kg, i.p. ) diminished tremor but failed to restore the burrowing activity in harmaline-treated mice. Importantly, both anti-tremor and burrowing activity restorative effects of Compound 6 (10 mg/kg, i.p. ) was significantly reversed by co-administration of i.cb. furosemide at a dose (10 nmol/0.5 μl) having no effect per se . All four α6GABA A R PAMs exhibited a similar therapeutic efficacy. Conclusion α6GABA A R-selective PAMs significantly attenuated action tremor and restored physical well-being in a mouse model mimicking ET by acting in the cerebellum. Thus, α6GABA A R-selective PAMs may be potential therapeutic agents for ET.
Effets des pannes des MEMS sur le rayonnement d'un réseau réflecteur reconfigurable (2009)

National audience
Attention-Deficit/Hyperactivity Disorder and Comorbid Subsyndromal Depression (2013)

Methylphenidate treatment is effective for both ADHD and SSD symptoms. It seems that ADHD symptoms are less responsive to MPH in patients with relatively high CDRS scores (possible depression) and that those patients may be candidates for selective serotonin reuptake inhibitor treatment as a supplement for MPH. Further, larger, placebo-controlled, double-blind studies are needed to examine the impact of MPH or d-amphetamine on patients with ADHD/SSD and ADHD/major depressive disorder.
Effect of polymorphism on the CH stretching region of the infrared spectrum of polyethylene (1978)

Abstract A complex fine structure in the CH stretching region of the infrared spectrum of deformed polyethylene single crystals is reported. The deformed crystals are shown to be transformed from the orthorhombic crystal form to a monoclinic structure. The previously deduced C 2/ m monoclinic structure does not account for the appearance of the new bands. An alternative but similar monoclinic structure is proposed. The symmetry of this structure is consistent with the Fermi resonance interactions required for the observation of these bands.
Reaction Dynamics and Dispersion of Energetic Biocides (2017)

Abstract : The objectives of this project are to probe the reactive and dispersion characteristics of energetic biocides (EB). We will employ a new mass-spectrometric tool to probe reaction dynamics, employ bulk combustion studies, and post-combustion analysis to assess the dispersion characteristics of the biocidal agent. Through these studies we hope to develop an understanding of the ignition and propagation of these EB systems and more specifically address the four primary goals.
Supplementary Figure Legend from Therapeutic Targeting the Loss of the Birt-Hogg-Dubé Suppressor Gene (2023)

Supplementary Figure Legend from Therapeutic Targeting the Loss of the Birt-Hogg-Dubé Suppressor Gene
Reconstruction and Membership Inference Attacks against Generative Models (2019)

We present two information leakage attacks that outperform previous work on membership inference against generative models. The first attack allows membership inference without assumptions on the type of the generative model. Contrary to previous evaluation metrics for generative models, like Kernel Density Estimation, it only considers samples of the model which are close to training data records. The second attack specifically targets Variational Autoencoders, achieving high membership inference accuracy. Furthermore, previous work mostly considers membership inference adversaries who perform single record membership inference. We argue for considering regulatory actors who perform set membership inference to identify the use of specific datasets for training. The attacks are evaluated on two generative model architectures, Generative Adversarial Networks (GANs) and Variational Autoencoders (VAEs), trained on standard image datasets. Our results show that the two attacks yield success rates superior to previous work on most data sets while at the same time having only very mild assumptions. We envision the two attacks in combination with the membership inference attack type formalization as especially useful. For example, to enforce data privacy standards and automatically assessing model quality in machine learning as a service setups. In practice, our work motivates the use of GANs since they prove less vulnerable against information leakage attacks while producing detailed samples.
Hemoscan™: A Dialysis Machine-Integrated Blood Volume Monitor (1995)

We describe an opto-electronic device capable of measuring the hemoglobin concentration (Hgb) non-invasively and continuously, hence the percentage changes in blood volume (BV) during dialysis treatment by means of the optical absorption of monochromatic light by the blood in the arterial line. This method has been validated during several in vitro and in vivo tests, during which the system has shown a low sensitivity to all the common intra-dialytic interference factors, such as oxygen saturation (max. err.=1.6%), blood flow (max. err. =1.8%), osmotic pressure (max. err.=0.7°) and hydraulic pressure (max. err.=0.6°), a high precision (std. err.≤0.1 g/dl) and a good accordance (Hgb mean err.=0.1 g/dl; std. err.=0.38 g/dl; BV mean err.=0.1%; std. err.=1.6%) with the corresponding values derived from standard laboratory tests.
High Coupling Efficiency Etched Facet Tapers in Silicon (2012)

We demonstrate etched facet silicon inverse tapers with coupling loss as low as 0.7dB per facet. This taper can be fabricated on a wafer scale enabling mass-production of silicon photonic devices with broadband, high-efficiency couplers.
Lean non-alcoholic fatty liver disease (Lean-NAFLD): a major cause of cryptogenic liver disease. (2011)

Lean-NAFLD is a new unrecognized clinicopathological entity, a frequent cause of cryptogenic liver disease.