gebhart/patrepeval huggingface dataset:
Determination of the absolute rate constants for the room temperature reactions of atomic sodium with ozone and nitrous oxide (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of the absolute rate constants for the room temperature reactions of atomic sodium with ozone and nitrous oxideJoel A. Silver and Charles E. KolbCite this: J. Phys. Chem. 1986, 90, 14, 3263–3266Publication Date (Print):July 1, 1986Publication History Published online1 May 2002Published inissue 1 July 1986https://doi.org/10.1021/j100405a042RIGHTS & PERMISSIONSArticle Views38Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts
A 60 Gb/s 1.9 pJ/bit NRZ optical-receiver with low latency digital CDR in 14nm CMOS FinFET (2017)

This work reports a low power implementation of a 60Gb/s NRZ optical receiver (RX) in 14nm bulk CMOS finFET featuring a first-order digital CDR with high jitter tolerance (JTOL). The design includes a single phase-rotator (PR) with low-complexity control logic suitable for high-speed applications. Multi-phase clock signals that drive data/edge slicers are created by an open loop quadrature clock generator. The circuit, characterized in an 850nm VCSEL based optical link, recovers PRBS7 data (BER<;10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> ) at 60Gb/s with a frequency tracking range of ±600ppm. The measured sinusoidal JTOL indicates a corner frequency of 80MHz, with high frequency JTOL of 0.16UI <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pp</sub> at -5dBm optical modulation amplitude (OMA). The RX energy efficiency is 1.9pJ/bit.
Front Cover: Triazolecarbaldehyde Reagents for One‐Step N‐Terminal Protein Modification (ChemBioChem 9/2020) (2020)

Hitting the target of the N terminus for protein modification is of paramount importance for constructing protein conjugates. An N-terminal-targeting molecule, 1H-1,2,3-triazole-4-carbaldehyde (T4AC) represented by an arrow in the Kyudo-styled cover artwork, enables specific modification of the protein. The T4AC molecule can be prepared from structures with an amine group by a single step Dimroth rearrangement. This method provides the N-terminal protein modification with a wide variety of functional molecules in a two-step process. More information can be found in the communication by A. Onoda, T. Hayashi, et al. on page 1274 in Issue 9, 2020 (DOI: 10.1002/cbic.201900692).
Mechanochromism and electroluminescence in positional isomers of tetraphenylethylene substituted phenanthroimidazoles (2017)

Three positional isomers (<italic>ortho</italic>,<italic>meta</italic>, and<italic>para</italic>) of phenanthroimidazoles<bold>3a–3c</bold>were synthesized and positional dependent AIE, mechanochromic and electroluminescence behaviour was explored.
A Highly Selective Compound for Lead:  Complexation Studies of Decamethylcucurbit[5]uril with Metal Ions (2000)

Calorimetric and potentiometric studies indicate that a cage-type compound, decamethylcucurbit[5]uril (MC5), shows very high selectivity for Pb2+ over alkali, alkaline-earth, NH4+, and Cd2+ cations. The selectivity factor is >105.5. Thermodynamic quantities (log K, ΔH, and ΔS values) for the interactions of MC5 with metal ions were determined at 25 °C by calorimetric titration in 50% formic acid/water (v/v) and by potentiometric titration in an aqueous solution. The log K(H2O) value for protonation of MC5 was determined to be 9.56. Pb2+ forms both 1:1 and 2:1 (Pb2+/MC5) complexes in 50% formic acid/water and aqueous solutions, while all other cations studied form only 1:1 complexes with MC5 in the 50% formic acid/water solution. However, both 1:1 and 2:1 complexes have been detected in an aqueous solution for Sr2+, indicating that the stoichiometry of MC5 complexes in 50% formic acid and in aqueous solutions could be different.
Hydrogels in the clinic (2022)

Injectable hydrogels are one of the most widely investigated and versatile technologies for drug delivery and tissue engineering applications. Hydrogels’ versatility arises from their tunable structure, which has been enabled by considerable advances in fields such as materials engineering, polymer science, and chemistry. Advances in these fields continue to lead to invention of new polymers, new approaches to crosslink polymers, new strategies to fabricate hydrogels, and new applications arising from hydrogels for improving healthcare. Various hydrogel technologies have received regulatory approval for healthcare applications ranging from cancer treatment to aesthetic corrections to spinal fusion. Beyond these applications, hydrogels are being studied in clinical settings for tissue regeneration, incontinence, and other applications. Here, we analyze the current clinical landscape of injectable hydrogel technologies, including hydrogels that have been clinically approved or are currently being investigated in clinical settings. We summarize our analysis to highlight key clinical areas that hydrogels have found sustained success in and further discuss challenges that may limit their future clinical translation.
On a Right-Inverse for the Divergence Operator in Spaces of Continuous Piecewise Polynomials (1997)

This paper is concerned with the norm of a right-inverse for the divergence operator between spaces of piecewise polynomials on triangular elements. More specifically, one tries to construct a right-inverse acting from the space W of continuous piecewise polynomials of degree p into the space V of R 2 -valued piecewise polynomials of degree p+1. Our results are as follows. Assume that we are dealing with a quasiuniform family of triangulations {M h } satisfying two additional hypotheses: M h can be transformed into a quadriangular mesh by grouping its element two by two and M h has no boundary vertex shared by only one or exactly three elements. In that context, one proves that the divergence has a right-inverse with an operator norm growing at most like [Formula: see text] when both W and V are equipped with the H 1 -norm and at most like [Formula: see text] if W is equipped with the L 2 -norm only. An application of the first of these two results is the approximation of the thermoelasticity equations by the p-version of the finite element methods. One also shows how the second result can be used in the context of higher-order Hood–Taylor method for Stokes problem.
Progress in Erbium Doped Fiber Amplifiers (1991)

Erbium fiber amplifiers are entering a fourth year of development with six commercial offerings now available, the result of rapid improvements in pump lasers, wavelength division multplexers, isolators and doped fiber designs. A number of challenges remain however to improve the performance and ensure reliability in field applications.
Gene Gain and Loss during Evolution of Obligate Parasitism in the White Rust Pathogen of Arabidopsis thaliana (2011)

Biotrophic eukaryotic plant pathogens require a living host for their growth and form an intimate haustorial interface with parasitized cells. Evolution to biotrophy occurred independently in fungal rusts and powdery mildews, and in oomycete white rusts and downy mildews. Biotroph evolution and molecular mechanisms of biotrophy are poorly understood. It has been proposed, but not shown, that obligate biotrophy results from (i) reduced selection for maintenance of biosynthetic pathways and (ii) gain of mechanisms to evade host recognition or suppress host defence. Here we use Illumina sequencing to define the genome, transcriptome, and gene models for the obligate biotroph oomycete and Arabidopsis parasite, Albugo laibachii. A. laibachii is a member of the Chromalveolata, which incorporates Heterokonts (containing the oomycetes), Apicomplexa (which includes human parasites like Plasmodium falciparum and Toxoplasma gondii), and four other taxa. From comparisons with other oomycete plant pathogens and other chromalveolates, we reveal independent loss of molybdenum-cofactor-requiring enzymes in downy mildews, white rusts, and the malaria parasite P. falciparum. Biotrophy also requires "effectors" to suppress host defence; we reveal RXLR and Crinkler effectors shared with other oomycetes, and also discover and verify a novel class of effectors, the "CHXCs", by showing effector delivery and effector functionality. Our findings suggest that evolution to progressively more intimate association between host and parasite results in reduced selection for retention of certain biosynthetic pathways, and particularly reduced selection for retention of molybdopterin-requiring biosynthetic pathways. These mechanisms are not only relevant to plant pathogenic oomycetes but also to human pathogens within the Chromalveolata.
Listeners lengthen phrase boundaries in self-paced music (2017)

Previous work has shown that musicians tend to slow down as they approach phrase boundaries (phrase-final lengthening). In the present experiments, we used a paradigm from the action perception literature, the dwell time paradigm (Hard, Recchia, &amp;amp; Tversky, 2011), to investigate whether participants engage in phrase boundary lengthening when self-pacing through musical sequences. When participants used a key press to produce each successive chord of Bach chorales, they dwelled longer on boundary chords than non-boundary chords in both the original chorales and atonal manipulations of the chorales. When a novel musical sequence was composed that controlled for metrical and melodic contour cues to boundaries, the dwell time difference between boundaries and non-boundaries was greater in the tonal condition than in the atonal condition. Furthermore, similar results were found for a group of non-musicians, suggesting that phrase-final lengthening in musical production is not dependent on musical training and can be evoked by harmonic cues.
Fluid Mechanics for Inkjet Printing (2015)

This chapter provides an overview of the principles of fluid mechanics with applications in the field of inkjet technology. The presentation is intended to be a survey of key topics. The topics covered include the basic properties of the fluids, underlying principles and equations that govern fluids in motion, computational methods for modeling fluid behavior, a brief overview of inkjet technology, and challenges in modeling inkjet systems. The chapter briefly reviews three key properties such as density, viscosity, and surface tension. In most conventional fluidic applications such as inkjet printing, one can adopt a continuum approximation wherein properties such as density, pressure, and velocity are well-defined within infinitely small volumes and vary continuously from point to point. It also briefly discusses the key components and processes of inkjet systems, and the application of computational modeling for the rational design of these systems.
3ASCA: Application-Aware Autonomous SCM Capacity Adjustment for SCM and NAND Flash Pooled Storage (2018)

Using storage class memories (SCMs) as non-volatile cache of NAND flash memory is a promising solution for the high performance storage. However, the problem is the high SCM cost per bit which is about 10 times higher than NAND flash and the optimal SCM capacity is application dependent. The optimum SCM capacity is conventionally determined manually for every application operating on the data centers' storages. To achieve high performance while reducing the overall storage cost, this paper proposes Application-Aware Autonomous SCM Capacity Adjustment (3ASCA) method. SCM capacity in hybrid memory pool of SCM and NAND flash is autonomously adjusted by observing the warm data in NAND flash. SCM-assisted eviction algorithm is also proposed to reduce the warm data and use SCM more efficiently. As a result, the total storage cost during storage operation is decreased by up to 42% while its IOPS performance is degraded by only 4.8%. If the access count in SCM is also considered by introducing SCM-assisted eviction algorithm, the total storage cost during one-week storage operation is further decreased by 6.4%.
Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging (2021)

Constitutive NF-κB activation is associated with cellular senescence and stem cell dysfunction and rare variants in NF-κB family members are enriched in centenarians. We recently identified a novel small molecule (SR12343) that inhibits IKK/NF-κB activation by disrupting the association between IKKβ and NEMO. Here we investigated the therapeutic effects of SR12343 on senescence and aging in three different mouse models. SR12343 reduced senescence-associated beta-galactosidase (SA-β-gal) activity in oxidative stress-induced senescent mouse embryonic fibroblasts as well as in etoposide-induced senescent human IMR90 cells. Chronic administration of SR12343 to the Ercc1<sup>-/</sup><sup>∆</sup> and Zmpste24<sup>-/-</sup> mouse models of accelerated aging reduced markers of cellular senescence and SASP and improved multiple parameters of aging. SR12343 also reduced markers of senescence and increased muscle fiber size in 2-year-old WT mice. Taken together, these results demonstrate that IKK/NF-κB signaling pathway represents a promising target for reducing markers of cellular senescence, extending healthspan and treating age-related diseases.
Small genomic insertions form enhancers that misregulate oncogenes (2017)

The non-coding regions of tumour cell genomes harbour a considerable fraction of total DNA sequence variation, but the functional contribution of these variants to tumorigenesis is ill-defined. Among these non-coding variants, somatic insertions are among the least well characterized due to challenges with interpreting short-read DNA sequences. Here, using a combination of Chip-seq to enrich enhancer DNA and a computational approach with multiple DNA alignment procedures, we identify enhancer-associated small insertion variants. Among the 102 tumour cell genomes we analyse, small insertions are frequently observed in enhancer DNA sequences near known oncogenes. Further study of one insertion, somatically acquired in primary leukaemia tumour genomes, reveals that it nucleates formation of an active enhancer that drives expression of the LMO2 oncogene. The approach described here to identify enhancer-associated small insertion variants provides a foundation for further study of these abnormalities across human cancers.
Comparison of a Standard and a Gender-Specific Posterior Cruciate-Substituting High-Flexion Knee Prosthesis. A Prospective, Randomized, Short-Term Outcome Study (2011)

Corresponding author: Giles R. Scuderi, MD, Insall Scott Kelly Institute, 210 East 64th Street, New York, NY 10065. E-mail address: [email protected]
ChemInform Abstract: Borylation of Arenes with Bis(hexylene glycolato)diboron. (2013)

Abstract The direct Ir‐catalyzed C‐H borylation of a variety of arenes with the commercially available title diboron reagent (II) is developed.
The Pathogenesis of Arteriovenous Malformations: Insights Provided by a Case of Multiple Arteriovenous Malformations Developing in Relation to a Developmental Venous Anomaly (1998)

Recently, increasing attention has focused on the possible importance of venous outflow disturbance and venous hypertension in the pathogenesis and pathophysiology of AVMs. The potential mechanisms for this association and the implications of the present case are discussed, and the pertinent literature is reviewed.
A New Calibration System for ECU Development (2003)

&lt;div class="htmlview paragraph"&gt;Automotive manufacturers and suppliers of electronic control units (ECUs) will be challenged more and more in the future to reduce costs and the time needed for ECU development. At the same time, increasing requirements concerning exhaust gas emissions, drivability, onboard diagnostics and fuel consumption have led to the growing complexity of modern engines and the associated management systems.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;As a result, the number and complexity of control parameters and look-up tables in the ECU software is increasing dramatically. Thus, in powertrain applications especially, calibration development has become a time-consuming and cost-intensive stage in the overall ECU development process.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;This paper describes the current situation in calibration development and shows how the new dSPACE Calibration System will face this situation. It provides an overview of the main benefits of the tool, which has been designed in close cooperation with calibration engineers. A special focus will be on how the tool contributes to saving calibration costs and development time.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Further emphasis will be placed on integration into the dSPACE tool chain, providing a complete environment for the development of ECU software. Interaction with tools for control design, function prototyping, target implementation and ECU testing will be detailed.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;In addition, the paper describes how international standards like ASAM/ASAP and NEXUS facilitate the calibration process and how these standards are supported by dSPACE.&lt;/div&gt;
Impact of age on outcomes after bone marrow transplantation for acquired aplastic anemia using HLA-matched sibling donors (2010)

Mortality risks increased with age. Risks were also higher in patients with a poor performance score and when the interval between diagnosis and transplantation was longer than 3 months, implying earlier referral would be appropriate when this treatment option is being considered.
Developing Hydrogen (H2) Specification Guidelines for Proton Exchange Membrane (PEM) Fuel Cell Vehicles (2005)

&lt;div class="htmlview paragraph"&gt;In 1999, the Society of Automotive Engineers established the Fuel Cell Standards Committee (FCSC). The Committee is organized in subcommittees that address issues such as Interface, Hydrogen (H&lt;sub&gt;2&lt;/sub&gt;) Quality, Safety, Performance, Emissions and Fuel Consumption, Recycling and Terminology. Since its inception the SAE/FCSC has published several recommended practices, which have drawn the attention of national and international organizations. These include SAE J2578 (Fuel Cell Vehicle Safety), SAE J2600 (Compressed H&lt;sub&gt;2&lt;/sub&gt; Surface Vehicle Refueling Devices), and SAE J2594 (Recyclability of Fuel Cell Systems).&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;The need for having one common grade of hydrogen for all US commercial hydrogen-refueling stations for FCVs was the reason to establish the H&lt;sub&gt;2&lt;/sub&gt; Quality Task Force (HQTF) in late 2003. At the present time there is no representative US-national or international standard addressing the quality of hydrogen fuel that is acceptable for fuel cell vehicles. Although the existing ISO standard 14687 was originally addressing PEM fuel cell vehicles, currently it is deemed by the industry as unsuitable and the document is amended by referring the readers to the new Technical Specification under development. As a result the mission of the HQTF is to ultimately develop a standard for commercial hydrogen fuel quality for H&lt;sub&gt;2&lt;/sub&gt; powered PEM fuel cell vehicles (FCVs). In the interim several H&lt;sub&gt;2&lt;/sub&gt; quality guidelines will be generated serving the immediate needs of demonstration PEM FCVs.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;The purpose of this technical report is to provide an overview of the HQTF status of activities and to share its progress to date with the fuel cell industry.&lt;/div&gt;
Differentiation‐inducing‐factor dechlorinase, a novel cytosolic dechlorinating enzyme from Dictyostelium discoideum (1992)

Differentiation-inducing factor 1 (DIF-1) is a dichlorinated alkyl phenone (1-[(3,5-dichloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one) from Dictyostelium discoideum, that induces amoebae to differentiate into stalk cells. It was shown previously that DIF-1 is rapidly metabolized into a series of more polar compounds by living cells [Traynor, D. & Kay, R.R. (1991) J. Biol. Chem. 266, 5291-5297]. The first step in DIF-1 metabolism is the formation of DIF metabolite 1 (now known to be DIF-3) by a monodechlorination. We report here the discovery of the enzyme activity catalyzing this dechlorination. A very sensitive enzyme assay was developed, using [3H]DIF-1 and a TLC system to separate DIF-1 from the product, DIF-3. DIF-1 3(5)-dechlorinase is present in the high-speed supernatant of cell lysates, and uses glutathione, at physiological concentrations, as cofactor. Kinetic measurements indicate a Km for DIF-1 of about 70 nM. The enzyme activity is inhibited by DIF-2 (the pentan-1-one analogue of DIF-1), with a median inhibitor concentration (IC50) of 1 microM, and DIF-3 (IC50 = 5 microM), which presumably act as substrates, but other compounds structurally related to DIF-1 were much less effective. Aurothioglucose, an inhibitor of selenocysteine enzymes, inhibited DIF-1 3(5)-dechlorinase with IC50 = 100 nM. DIF-1 3(5)-dechlorinase activity is developmentally regulated. It is essentially absent from growing cells and increases at the end of aggregation to reach a first peak of activity at the first finger stage, with a further rise at culmination.
NDF/heregulin induces persistence of terminal end buds and adenocarcinomas in the mammary glands of transgenic mice. (1996)

Neu differentiation factor (NDF), a member of the neuregulin family of ligands of erbB receptors, induces both differentiative and mitogenic effects on cultured human mammary epithelial cells. Since members of the epidermal growth factor receptor family, including Neu/erbB2, have been implicated in mammary carcinoma, we wished to know whether a potential ligand of this family, NDF, could induce such effects in the mammary gland in vivo. We therefore targeted expression of NDF to the mammary gland of transgenic mice using the mouse mammary tumor virus (MMTV) promoter in a fusion construct. There was a clear, but subtle effect on development of the adult virgin gland of female transgenic animals. Terminal end bud structures (TEBs), which normally disappear from the mammary gland at the age of approximately 8 weeks in wild type mice, persist in glands of virgin MMTV-NDF transgenic females, suggesting that NDF inhibits signals that normally lead to the terminal differentiation of these structures. Further, female mice, bred continuously to maximize expression of the transgene in the mammary gland, develop mammary adenocarcinomas at a median age of 12 months. Since these tumors arise in a solitary fashion, we infer that NDF is necessary, but not sufficient for their formation. In order to explore the signal transduction pathways potentially activated by NDF, we examined expression of the receptors erbB2, erbB3 and erbB4 in mammary epithelial cells established from an NDF-induced tumor. All three receptors were expressed, though only the erbB3 receptor was phosphorylated, suggesting that overexpression of NDF might operate through this receptor. Additionally, about 50% of MMTV-NDF transgenic mice developed Harderian (lachrymal) gland hyperplasia, a benign tumor that does not progress to frank malignancy.