gebhart/patrepeval huggingface dataset:
Sequence‐Defined Oligomers from Hydroxyproline Building Blocks for Parallel Synthesis Applications (2016)

Abstract The functionality of natural biopolymers has inspired significant effort to develop sequence‐defined synthetic polymers for applications including molecular recognition, self‐assembly, and catalysis. Conjugation of synthetic materials to biomacromolecules has played an increasingly important role in drug delivery and biomaterials. We developed a controlled synthesis of novel oligomers from hydroxyproline‐based building blocks and conjugated these materials to siRNA. Hydroxyproline‐based monomers enable the incorporation of broad structural diversity into defined polymer chains. Using a perfluorocarbon purification handle, we were able to purify diverse oligomers through a single solid‐phase extraction method. The efficiency of synthesis was demonstrated by building 14 unique trimers and 4 hexamers from 6 diverse building blocks. We then adapted this method to the parallel synthesis of hundreds of materials in 96‐well plates. This strategy provides a platform for the screening of libraries of modified biomolecules.
Expansion of the CD4−, CD8− γδ T cell subset in the spleens of mice during non‐lethal blood‐stage malaria (1993)

Splenic gamma delta T cells (CD4-, CD8-) increased more than 10-fold upon resolution of either Plasmodium chabaudi adami or P.c. chabaudi infections in C57BL/6 mice compared to controls. Similarly, a 10- to 20-fold expansion of the gamma delta T cell population was observed in beta 2-microglobulin deficient (beta 2-m0/0) mice that had resolved P.c. adami, P.c. chabaudi or P. yoelii yoelii infections. In contrast, increases in the number of splenic alpha beta T cells in these infected mice were only two to three-fold indicating a differential expansion of the gamma delta T cell subset during malaria. Because nucleated cells of beta 2-m0/0 mice lack surface expression of major histocompatibility complex class I and class Ib glycoproteins, our findings suggest that antigen presentation by these glycoproteins is not necessary for the increasing number of gamma delta T cells. Our observation that after resolution of P.c. adami malaria, C57BL/6 mice depleted of CD8+ cells by monoclonal antibody treatment had lower numbers of gamma delta T cells than untreated controls suggests that the demonstrated lack of CD8+ cells in beta 2-m0/0 mice does not contribute to the expansion of the gamma delta T cell population during non-lethal malaria.
Corpus-Derived First, Second and Third-Order Word Affinities (1994)

A number of corpus-based extraction techniques have been successfully implemented which derive lists of similar words, based on some definition of the context in which they are found, from a corpus. We present here the results of affining such a list in order to extract semantic axes expressing nuances of a word&amp;apos;s meaning. These semantic axes represent corpus-based meaning distinctions that are based on the word&amp;apos;s usage in the corpus. 1.
Advanced high-κ dielectric stacks with polySi and metal gates: Recent progress and current challenges (2006)

The paper reviews our recent progress and current challenges in implementing advanced gate stacks composed of high-κ dielectric materials and metal gates in mainstream Si CMOS technology. In particular, we address stacks of doped polySi gate electrodes on ultrathin layers of high-κ dielectrics, dual-workfunction metal-gate technology, and fully silicided gates. Materials and device characterization, processing, and integration issues are discussed.
System development for profiling deeper waters in support of the oil and gas industry (1999)

In recent years, the exploration and production activities of the oil and gas industry have been expanding into deeper water. With this expansion came a demand for reliable and continuous ocean current measurements throughout the water column over deeper ranges than previously required. Meeting this demand has required developing new systems that combine new instrumentation, deployment schemes, and real time software for data display and forecasting. This paper discusses some of the problems that had to be solved in meeting this new demand. Operating acoustic instrumentation such as ADCPs around oil and gas platforms has to combat both acoustic noise sources and obstacles in the water. The noise sources include plant and platform noise as well as flow noise generated by thrusters. The noise problem worsens as the acoustic systems operate at lower frequencies. Submerged obstacles that can interfere with the ADCP's acoustic beams include legs, lines, and risers. In this paper, the authors discuss data and field experiences from collaborative work between RD Instruments, Fugro/GEOS, and Shell E&P Technology Company. The project involved Shell's working with Fugro/GEOS as system integrator to deploy RDI's state of the art 38 kHz Phased Array ADCP. Innovative aspects of the work include new instrument technology-hardware & firmware-different deployment schemes to optimize data, and specific software development for real time data display of the current profiling and current forecasting in support of offshore oil and gas deployments.
Abstract 16420: Human Cardiac Stem Cells (hCSCs) Carrying the Mother DNA Constitute a Novel Class of Resident Stem Cells With Markedly Superior Growth Reserve (2011)

Cell therapy for the failing heart requires recognition of the most powerful cell for myocardial regeneration. Here, we established whether hCSCs divide by symmetric and asymmetric DNA segregation,...
On-chip infrared spectroscopic sensing: Redefining the benefits of scaling (2016)

Infrared (IR) spectroscopy is widely recognized as a gold standard technique for chemical analysis. Traditional IR spectroscopy relies on fragile bench-top instruments located in dedicated laboratory settings, and is thus not suitable for emerging field-deployed applications such as in-line industrial process control, environmental monitoring, and point-of-care diagnosis. Recent strides in photonic integration technologies provide a promising route towards enabling miniaturized, rugged platforms for IR spectroscopic analysis. It is therefore attempting to simply replace the bulky discrete optical elements used in conventional IR spectroscopy with their on-chip counterparts. This size down-scaling approach, however, cripples the system performance as both the sensitivity of spectroscopic sensors and spectral resolution of spectrometers scale with optical path length. In light of this challenge, we will discuss two novel photonic device designs uniquely capable of reaping performance benefits from microphotonic scaling. We leverage strong optical and thermal confinement in judiciously designed micro-cavities to circumvent the thermal diffusion and optical diffraction limits in conventional photothermal sensors and achieve a record 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> photothermal sensitivity enhancement [1–3]. In the second example, an on-chip spectrometer design with the Fellgett's advantage is analyzed. The design enables sub-nm spectral resolution on a millimeter-sized, fully packaged chip without moving parts.
From 5G to 6G: will compound semiconductors make the difference? (2020)

In this work, we will address the opportunities of a hybrid III-V/CMOS technology for next generation wireless communication, beyond 5G, moving to operating frequencies above 100GHz. Challenges related to III-V upscaling and CMOS co-integration using 3D technologies will be discussed.
Low-loss, single-mode photonic wires and ring resonators in silicon-on-insulator (2004)

We demonstrate single-mode photonic wires in silicon-on-insulator with propagation losses as low as 2.4 dB/cm. We also constructed compact racetrack and resonators in these waveguides with a Q larger than 3000.
Data from Inhibition of BMI1, a Therapeutic Approach in Endometrial Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;With rising incidence rates, endometrial cancer is one of the most common gynecologic malignancies in the United States. Although surgery provides significant survival benefit to early-stage patients, those with advanced or recurrent metastatic disease have a dismal prognosis. Limited treatment options include chemotherapy and radiotherapy. Hence, there is a compelling need for developing molecularly targeted therapy. Here, we show that the polycomb ring finger protein BMI1, also known as a stem cell factor, is significantly overexpressed in endometrial cancer cell lines, endometrial cancer patient tissues as well as in nonendometrioid histologies and associated with poor overall survival. PTC-028, a second-generation inhibitor of BMI1 function, decreases invasion of endometrial cancer cells and potentiates caspase-dependent apoptosis, while normal cells with minimal expression of BMI1 remain unaffected. In an aggressive uterine carcinosarcoma xenograft model, single-agent PTC-028 significantly delayed tumor growth and increased tumor doubling time compared with the standard carboplatin/paclitaxel therapy. Therefore, anti-BMI1 strategies may represent a promising targeted approach in patients with advanced or recurrent endometrial cancer, a population where treatment options are limited. &lt;i&gt;Mol Cancer Ther; 17(10); 2136–43. ©2018 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
EVIDENCE THAT GLUCOCORTICOSTEROIDS BLOCK EXPRESSION OF THE HUMAN INTERLEUKIN-6 GENE BY ACCESSORY CELLS (1990)

The mode of action of glucocorticosteroids as immunosuppressive and antiinflammatory agents is not fully understood. Glucocorticosteroids block synthesis of interleukin 1 by interfering with the transcription of the IL-1 beta gene. Glucocorticosteroids may also induce rapid degradation of IL-1 mRNA. In the presence of antigen, IL-1 is a potent accessory-cell-derived growth and differentiation co-factor for stimulating resting T lymphocytes. The recently defined interleukin 6 protein is even more powerful than IL-1 in promoting T cell growth and differentiation and acts synergistically with IL-1. Like IL-1, IL-6 is produced by accessory cells and exhibits pleiotropic functions. We herein describe the effects of glucocorticosteroids on IL-6 synthesis. We provide evidence that glucocorticosteroids prevent IL-6 gene transcription in human peripheral blood mononuclear cells.
52.4: Distinguished Paper : Electrical Properties of Amorphous InGaZnO Thin‐Film Transistors Prepared by Magnetron Sputtering with Using Kr and Xe Instead of Ar (2013)

Abstract Heavier noble gases of Kr and Xe instead of the lighter Ar during the magnetron‐sputtering deposition of amorphous indium—gallium‐zinc oxide films are introduced in fabricating their thin‐film transistors. Higher field effect mobility can be obtained by introducing heavier noble gases, while gate bias stability shows no significant difference between gas species. Raman spectroscopic analysis suggests that the disordered structure in the film is suppressed by introducing heavier noble gases. These results suggest that the introduction of heavy noble gases can reduce damage to film by ion bombardment during the sputtering depositions, resulting in the improvement of field effect mobility.
Proposed Revision of the Standard Weight (WS) Equation for Smallmouth Bass (1993)

Weight-length data from 50 populations of smallmouth bass Micropterus dolomieu (N = 6,731) in 19 states were used to develop a revised standard weight (WS) equation for smallmouth bass. The regression-line–percentile (RLP) technique was used to develop the proposed 75th-percentile WS equation from length-weight regressions for individual smallmouth bass populations. The proposed Ws equation, log10 WS (weight, g) = −5.329 + 3.200 log10 L(total length, mm), is valid for fish 150 mm long and longer. The English-unit equivalent, log10 WS(lb) = −3.491 + 3.200 log10 L(total length, in), is valid for fish 6 in long and longer.
Efficacy of omalizumab in the treatment of severe chronic rhinosinusitis with polyposis (CRSwNP) (2022)

Introduction CRSwNP is a widespread, heterogeneous disease. For therapy, in addition to intranasal corticosteroids (INCS) and surgical remediation, the use of biologics has recently become available. The present study investigated the efficacy of omalizumab in patients with severe CRSwNP.
Analysis and design of parallel mechanisms with flexure joints (2005)

Flexure joints are frequently used in precision-motion stages and microrobotic mechanisms due to their monolithic construction. The joint compliance, however, can affect the static and dynamic performance of the overall mechanism. In this paper, we consider the analysis and design of general platform-type parallel mechanisms containing flexure joints. Based on static performance measures such as task-space stiffness and manipulability, and constraints such as joint stress, mechanism size, and workspace volume, we pose the design problem as a multiobjective optimization. We first calculate the Pareto frontier, which can then be used to select the desired design parameters based on secondary criteria, such as performance sensitivity and dynamic characteristics. To facilitate design iteration, we apply the pseudo rigid-body approach with a lumped approximation of the flexure joints. A planar mechanism is used to illustrate the analysis and design techniques.
An antibody that inhibits the binding of diphtheria toxin to cells revealed the association of a 27-kDa membrane protein with the diphtheria toxin receptor. (1991)

A monoclonal antibody that blocks the binding of diphtheria toxin to Vero cells was isolated by immunizing mice with Vero cell membrane. The antibody inhibits the binding of diphtheria toxin and also CRM197, a mutant form of diphtheria toxin, to Vero cells, and consequently inhibits the cytotoxicity of diphtheria toxin. This antibody does not directly react with the receptor molecule of diphtheria toxin (DTR14.5). Immunoprecipitation and immunoblotting studies revealed that this antibody binds to a novel membrane protein of 27 kDa (DRAP27). When diphtheria toxin receptor was passed through an affinity column made with this antibody, the receptor was trapped only in the presence of DRAP27. These results indicate that DRAP27 and DTR14.5 closely associate in Vero cell membrane and that the inhibition of the binding of diphtheria toxin to the receptor is due to the binding of the antibody to the DRAP27 molecule. Binding studies using 125I-labeled antibody showed that there are many more molecules of DRAP27 on the cell surface than diphtheria toxin-binding sites. However, there is a correlation between the sensitivity of a cell line to diphtheria toxin and the number of DRAP27 molecules on the cell surface, suggesting that DRAP27 is involved in the entry of diphtheria toxin into the target cell.
Compact Swimming Mechanism with Wire-driven Continuum Waterjet Nozzle (2017)

In this research, we propose a propulsion mechanism of a swimming quick capable of rapid turning. In this swimming mechanism of the underwater robot, the rod-shaped continuum waterjet pipe is oriented in all directions by wire driving, and therefore aims to achieve quick turning with a small turning radius. In the swimming robot using this swimming mechanism, the water flow generated by the waterjet injection tube passes through a hollow elastic rod deformable by wire driving and becomes a propulsive force. In this paper, we show the composition of the swimming mechanism with the waterjet pipe by pulling-wire drive, and the actual behavior of the mechanism under the operation.
Understanding the Vulnerabilities of a SOA Platform - A Case Study (2010)

Service-oriented architecture (SOA) is a powerful distributed computing paradigm that provides high-level abstractions for developing, deploying, and executing distributed systems while hiding many platform-level details. SOA platforms host functionality as deployed services, support decoupled interaction between service providers and service consumers, and manage low-level plumbing and dispatching among various deployed components. As with any distributed computing platform, SOA presents challenges for security and survivability beyond those that exist in more static and local platforms. As SOA platforms become popular and more widely used in a variety of distributed systems, it is important to explore their security challenges and vulnerabilities, and to understand how well those are addressed by the current security features of SOA platforms. This paper reports on a case study that evaluated the vulnerability profile of a SOA platform based on the popular open source JBoss Application Server.
2,3-exo-Diheterotactic Dicyclopentadiene Oligomers: An X-ray Powder Diffraction Study of a Challenging Multiphase Case (2019)

Cycloaliphatic polyolefins have attracted attention for use as functional materials, but they are rarely observed in the crystalline state. New semicrystalline dicyclopentadiene oligomers were obtained with an iminopyridine chromium complex in combination with methylaluminoxane. Fourier transform infrared and nuclear magnetic resonance measurements did not allow us to establish the chain stereochemistry, and size exclusion chromatography measurements merely revealed that the obtained sample contained oligomers of different molecular masses. The wide-angle X-ray diffraction (WAXS) powder pattern showed a remarkable crystalline character of the sample, and its study was considered the main route toward the comprehension of the obtained material. By analogy with the norbornene olefin, there was conjecture that the obtained dicyclopentadiene oligomers featured a 2,3-exo-diheterotactic stereoregularity. Then, different ad hoc computational techniques were implemented to describe the WAXS powder pattern in terms of a model mixture of perfect crystals of oligomers with different numbers of monomer units and with the mentioned stereoregularity. This modeling allowed us to shed light on the structures of crystals constituted by oligomers of different masses, to estimate their abundance in the sample, and to confirm the suggested chain stereochemistry, which has never been observed before in dicyclopentadiene macromolecules.
Controversies in postoperative atrial fibrillation after noncardiothoracic surgery: clinical and research implications (2017)

Post operative atrial fibrillation after non-cardiothoracic surgery is an increasingly common problem. There is little high quality data to guide clinicians in risk prediction as well as short term and long term management. There appears to be a significant risk of recurrent atrial fibrillation and stroke but effective screening strategies have not been tested. In this commentary, we delineate various controversies in the management of post operative atrial fibrillation and briefly review the available evidence. Prospective studies in this clinically important area of cardiology should be encouraged.
Identification of T‐cell antigens expressed by metastatic T‐cell hybridomas and lymphomas (1990)

Using the murine BW5147 tumor model system, we have identified 3 MAbs that discriminate between metastatic and non-metastatic BW5147-derived T-cell hybridomas and BW5147-unrelated T-lymphomas. The 3 rat MAbs appear to recognize an identical membrane-associated sialoglycoprotein with an approximate molecular weight of 95-100 kDa. We thus defined "metastatic T-cell hybridoma" antigens (MTH-Ags) that are also expressed on normal T-lymphocytes. No correlation was found between the expression of the MTH Ags and in vitro invasive behavior of normal and malignant cells. Neither did we find any relationship between organ specificity of i.v. inoculated tumor cells and their MTH-Ags expression. It thus remains unclear whether our MTH-Ags are functionally involved in the metastatic process, or whether their expression is only incidentally related to the metastatic potential.
Immunodeficiency with defective T-cell response to interleukin 1. (1984)

Normal proliferation of T cells in vitro requires production of and response to the lymphokine interleukin 2 (IL-2). Optimal IL-2 production by T cells is dependent on the monokine interleukin 1 (IL-1). A 10-year-old male with recurrent infections and failure to thrive was evaluated for possible defects in the production and response to IL-1 and IL-2. The patient had normal levels of serum immunoglobulins and a normal distribution of circulating T-cell subsets. However, the in vitro proliferative response of his peripheral blood mononuclear cells (PBMC) to phytohemagglutinin was depressed (40% of normal) and the response of his PBMC to antigens was absent. Delayed hypersensitivity skin tests and in vitro response to tetanus toxoid remained absent despite repeated immunizations. Monocyte function in this patient was normal as judged by the following criteria: normal expression of Ia antigens (77% +), normal IL-1 production, and normal capacity to present tetanus toxoid to a maternal T-cell line specific for tetanus toxoid antigen. The abnormal phytohemagglutinin response of the patient's PBMC was corrected by the addition of exogenous IL-2. IL-2 production by the patient's phytohemagglutin-stimulated PBMC was severely deficient but was corrected by the addition of phorbol 12-myristate 13-acetate, suggesting a defective response to IL-1. T-cell blasts derived from a normal subject but not T-cell blasts derived from the patient absorbed out IL-1 activity from a preparation of purified human IL-1. These results indicate that the patient's T-cell deficiency was due to a defective T-cell response to IL-1 and suggest that IL-1 plays an important role in the in vivo immune response.
Mechanisms Leading to an Oriented Immobilization of Recombinant Proteins Derived from the P24 Capsid of HIV-1 onto Copolymers (2001)

To investigate the mechanism leading to an oriented immobilization of recombinant proteins onto synthetic copolymers, five genetically modified HIV-1 p24 capsid proteins (RH24, RH24A4K2, RH24R6, RH24R4K2, and RH24K6) were tested for their efficiency to covalently bind to maleic anhydride-alt-methyl vinyl ether (MAMVE) and N-vinyl pyrrolidone-alt-maleic anhydride (NVPMA) copolymers. These proteins contain, at their C-termini, tags differing in cationic and/or reactive amino acids density. We demonstrated that an increase of the charge and amine density in the tag enhances the coupling yield, the most efficient tag being a six lysine one. The reactivity of the proteins depends directly on the reactivity of the tag, and this led us to conclude that the tag was the site where the covalent grafting with the polymer occurred. Thus, design of such tags provides a new efficient and versatile method allowing oriented immobilization of recombinant proteins onto copolymers.