gebhart/patrepeval huggingface dataset:
Abstract 3906: Design, synthesis and biological evaluation of 2nd generation ezrin inhibitors for metastatic osteosarcoma (2012)

Abstract Though advancements in chemotherapy and surgical techniques have ameliorated treatment of primary osteosarcoma (OS), the metastatic phenotype remains a clinical challenge. Overall five-year survival rates for patients with localized OS have improved to 60-70%, yet survival rates of patients with metastasis remains at 20-30% with mortality linked to metastatis-induced respiratory failure. Therefore, targeting fundamental molecular events that lead to metastasis may yield significant benefit to patients with OS. Accumulating evidence from clinical samples and pre-clinical animal models suggests that ezrin is a key regulator in the metastasis of OS cells. Ezrin is a multifunctional protein that connects the actin cytoskeleton to extracellular matrix through transmembrane proteins and a critical component for cell motility, adhesion and shape. We have recently identified that a small molecule, NSC 668394 acts as a potent and selective inhibitor of ezrin function and inhibits migration in both in-vitro and in-vivo models. Moreover, suppression of ezrin phosphorylation by NSC 668394 significantly reduced the metastatic behavior in cellular and animal models and has thus emerged as an important lead inhibitor. Consequently, we conducted a series of structure-activity-relationship (SAR) studies that monitored direct binding; OS cell migration and HUVEC monolayer invasion in ‘real-time’ with surface-plasmon resonance and electrical impedance technology. From our 2nd generation library, we have designed novel candidate inhibitors which feature enhanced ezrin-binding affinity, and improved anti-migration and anti-invasion activities. In addition to their potency against the different stages of OS metastasis, these compounds possess other desirable attributes for development including good druggable physical-chemical characteristics and are currently undergoing further preclinical evaluation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3906. doi:1538-7445.AM2012-3906
Recent advances in the development of aryl-based foldamers (2009)

In recent years, significant effort has gone into making synthetic oligomers that can attain well-defined conformations analogous to the folding of biomolecules. The diversity of the structural building blocks ranges from peptidic and other aliphatic repeat units to aromatic ones, which do not have a natural counterpart. In this critical review, we will focus on the developments in aromatic foldamers in the last two years and their potential applications. This review will be of interest to people working on the structural and functional mimicry of biomolecules and will, we hope, stimulate further research into novel applications (149 references).
Front Cover: Organosilica Nanoparticles for Gemcitabine Monophosphate Delivery in Cancer Cells (ChemNanoMat 7/2019) (2019)

Two kinds of organosilica nanoparticles based on ionosilicas or neutral tertiary amino compounds have been loaded with gemcitabine monophosphate and are able to deliver the drug in cancer cells due to phosphate exchange or pH stimulus. Both nanoparticles are endocytosed in cancer cells, as monitored by fluorescence microscopy, and are very efficient, leading to 60% cancer cell death. These nanoparticles are therefore promising vectors for nanomedicine applications against tumors. More information can be found in the Full Paper by Magali Gary-Bobo, Jean-Olivier Durand, Peter Hesemann et al. on page 888 in Issue 7, 2019 (DOI: 10.1002/cnma.201900202).
Message classification in the call center (2000)

Customer care in technical domains is increasingly based on e-mail communication, allowing for the reproduction of approved solutions. Identifying the customer's problem is often time-consuming, as the problem space changes if new products are launched. This paper describes a new approach to the classification of e-mail requests based on shallow text processing and machine learning techniques. It is implemented within an assistance system for call center agents that is used in a commercial setting.
Studies on organic fluorine compounds. XLVII. Synthesis of trifluoromethylated sugars through the aldol reaction of 2-trimethylsilyloxy-4-trifluoromethylfuran. (1985)

Lewis acid-catalyzed aldol condensation of 2-trimethylsilyloxy-4-trifluoromethylfuran (2a) with aldehydes was found to proceed in a regio- and diastereoselective manner to give the 5-substituted 4-trifluoromethyl-2 (5H)-furanone (4) in good yield. The aldol product (4a) derived from benzyloxyacetaldehyde was successfully converted to the branched sugar (12), the first reported example of a trifluoromethylated branched sugar, and its crystal structure was determined by X-ray analysis.
Plane, Ray, and Point (2019)

We present Plane, Ray, and Point, a set of interaction techniques that utilizes shape constraints to enable quick and precise object alignment and manipulation in virtual reality. Users create the three types of shape constraints, Plane, Ray, and Point, by using symbolic gestures. The shape constraints are used like scaffoldings and limit and guide the movement of virtual objects that collide or intersect with them. The same set of gestures can be performed with the other hand, which allow users to further control the degrees of freedom for precise and constrained manipulation. The combination of shape constraints and bimanual gestures yield a rich set of interaction techniques to support object transformation. An exploratory study conducted with 3D design experts and novice users found the techniques to be useful in 3D scene design workflows and easy to learn and use.
An Optical/Electrical Test System for 100-Gb/s Optical Interconnection Devices for High Volume Production (2016)

100-Gb/s optical interconnection devices are expected to be deployed widely in large scale datacenters. In order to improve the productivity of these optical devices, this paper proposes a test solution equipped with 16-lanes of 28-Gb/s both optical and electrical interfaces. In addition to these high-speed ports to test the devices, the test solution also includes device fixture technology which provides stable and repeatable insertion loss for more than 100,000 repeated plug/unplug operations. This test solution can be applied to high speed optical interconnection device testing in high volume manufacturing.
Correction: Discovery of Molecular Markers to Discriminate Corneal Endothelial Cells in the Human Body (2015)

There is an error in the legend for Fig 2. Please see the complete, correct Fig 2 legend here.



Fig 2

qRT-PCR analysis of 5 corneal endothelial cell marker candidate genes within ocular tissues.
Supplementary Materials and Methods, Supplementary Tables I and II, and Supplementary Figure Legends from A Squalene-Based Nanomedicine for Oral Treatment of Colon Cancer (2023)

&lt;p&gt;Supplementary Materials and Methods, Supplementary Tables I and II, and Supplementary Figure Legends&lt;/p&gt;
ChemInform Abstract: 4‐(trans‐4‐Methylcyclohexyl)‐4‐oxobutyric Acid (JTT‐608). A New Class of Antidiabetic Agent. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Digitally intensive wireless transceivers (2012)

In this review article, the author revisits the digitization journey of wireless systems and the motivations that have driven this research field, gives a brief yet concise summary of state-of-the-art solutions, and offers insights for future developments.
Combination of nuclear NF-kB/p65 localization and gland morphological features from surgical specimens appears to be predictive of early biochemical recurrence in prostate cancer patients (2018)

Identifying patients who are high-risk for biochemical recurrence (BCR) following radical prostatectomy could enable direction of adjuvant therapy to those patients while sparing low-risk patients the side effects of treatment. Current BCR prediction tools require human judgment, limiting repeatability and accuracy. Quantitative histomorphometry (QH) is the extraction of quantitative descriptors of morphology and texture from digitized tissue slides. These features are used in conjunction with machine learning classifiers for disease diagnosis and prediction. Features quantifying gland orientation disorder have been found to be predictive of BCR. Separately, staining intensity of NF-&kappa;B protein family member RelA/p65, which regulates cell growth, apoptosis, and angiogensis, has been connected to BCR. In this study we combine nuclear NF-&Kappa;B/p65 and H and E gland morphology features to structurally and functionally characterize prostate cancer. This enables description of cancer phenotypes according to cellular molecular profile and social behavior. We collected radical prostatectomy specimens from 21 patients, 7 of whom experienced BCR (prostate specific antigen &gt;; .2 ng/ml) within two years of surgery. Our goal was to demonstrate the value of combining morphological and functional information for BCR prediction. Firstly, we used the top two features from each stain channel via the Wilcoxon rank-sum test using a leave-one-out cross validation approach in conjunction with a linear discriminant analysis classifier. Secondly we used the product of the posterior class probabilities from each classifier to produce an aggregate classifier. Accuracy was 0.76 with H and E features alone, 0.71 with NF-κB/p65 features alone, and 0.81 via the aggregate model.
Mersenne factorization factory. (2014)

We present work in progress to completely factor seventeen Mersenne numbers using a variant of the special number field sieve where sieving on the algebraic side is shared among the numbers. It is expected that it reduces the overall factoring effort by more than 50%. As far as we know this is the first practical application of Coppersmith’s “factorization factory” idea. Most factorizations used a new double-product approach that led to additional savings in the matrix step.
Fallbericht: Verzögert einsetzende Multi-Organ-Toxizitäten bei einem Melanompatienten, der ein vollständiges Ansprechen auf BRAF/MEK-Hemmung erreicht (2022)

Autoimmuntoxizitäten, die nach der Behandlung mit Krebsimmuntherapien häufig auftreten, sind bei Patienten, die mit BRAF/MEK-Inhibitoren behandelt werden, nicht gut charakterisiert. Neuere Daten deuten darauf hin, dass Autoimmuneffekte mit einem überragenden Ansprechen auf beide Behandlungsmodalitäten verbunden sein können; es gibt jedoch wenig Evidenz, die Mechanismen der immunbedingten Toxizität für Patienten unter BRAF/MEK-Inhibitoren beschreibt. Hier beschreiben wir die Erfahrungen eines 59-jährigen HLA-A2, A29, B27-positiven Mannes mit rezidivierendem/metastasierendem Melanom. Nach Progression unter Checkpoint-Inhibitor-Therapie wurde er mit Dabrafenib/Trametinib, gefolgt von Encorafenib/Binimetinib, behandelt, die gut vertragen wurden und zu einem vollständigen Ansprechen führten. 18 Monate nach der BRAF/MEK-Inhibitor-Therapie und drei Monate nach dem ersten vollständigen Ansprechen entwickelte er eine Reihe plötzlich einsetzender, schwerer Toxizitäten: nämlich bilaterale Panuveitis, Zytopenien, Gelenkschmerzen, Hautausschlag, Hyperkalzämie und interstitielle Nephritis, die zu einem BRAF/MEKi-Abbruch führten. Immunologische Analysen zeigten die Induktion einer peripheren Typ-17-Zytokin-Signatur, die durch hohe IL-23-, IL-6-, IL-10-, IL-17A/F-, IL-113- und IL-21-Zytokine im Plasma gekennzeichnet ist, die dem Ausmaß der Symptome entsprechen. Diese Ergebnisse zeigen einen neuen Fall einer verzögerten autoimmunähnlichen Reaktion auf die BRAF/MEK-Inhibition und weisen auf eine mögliche Rolle der ThiTc17-Aktivierung in ihrer Pathogenese hin, was eine zukünftige klinische und immunologische Charakterisierung rechtfertigt.
Identification of novel host-oriented targets for Human Immunodeficiency Virus type 1 using Random Homozygous Gene Perturbation (2009)

These studies demonstrate the power of RHGP to identify novel host targets that are essential for the viral life cycle but which can be safely perturbed without overt cytotoxicity. These findings suggest opportunities for the future development of host-oriented therapeutics with the broad spectrum potential for safe and effective inhibition of HIV infection.
Amyloid-Œ≤ Deposition in Rat Brain: Histopathological and Functional Sequelae (1997)

Alzheimer's disease (AD) is characterized histopathologically by neurofibrillary tangles, senile plaques, reactive astrocytes and microglia, neuronal shrinkage, and cell loss in various brain regions.These pathological changes are associated with neurochemical deficits and cognitive impairments.Senile plaques consist predominantly of amyloid-P (APl peptide, that has been proposed to have a prominent role in the pathogenesis of AD.The main component of the tangles is paired helical filaments, which consist largely of the protein tau in an abnormal state of phosphorylation.There is currently no treatment available that effectively slows or halts the progression of AD.The main reason for this is the relative lack of an animal model that has the features of the disease, in which potential therapeutic drugs could be screened.The main objective of this dissertation work was to develop a rat model of the histopathological hallmarks of AD.Because the early and primary histopathological changes in AD are predominantly found in temporal lobe structures, it was determined if intra-amygdaloid injections of AP 25-35 in the rat induced the appearance of abnormal tau proteins and reactive astrocytes as seen in AD.It was also examined if the effects of AP were time dependent, included neuronal shrinkage and microglial activation, and if these changes were associated with neurochemical and behavioral alterations.AP induced abnormal neuronal tau staining in the right amygdala and hippocampus.AP also induced reactive astrocytosis and neuronal shrinkage within the right hippocampus and amygdala, respectively.The same brain regions within the left hemisphere were significantly less affected.In addition, AP appeared to induce microglial proliferation and xi neuronal interleukin-1 P staining.The histopathological effects of AP peaked at 32 days postoperatively and were associated with minimal behavioral impairments.These effects were not associated with a reduction in amygdaloid choline acetyltransferase activity at 32 days postinjection.These data demonstrate that intra-amygdaloid injections of AP induce transsynaptic cytoskeletal and astrogliotic reactions.These findings also suggest a laterality in the histopathological effects of AP and that the effects of single injections are in part transient.Identification of the cause for the lateralized effect of AP may prove valuable for understanding the etiology of AD and provide possible therapeutic strategies designed to slow the progression of the disease.In addition, these results suggest a direct association between plaque and tangle formation in AD, and support the use of this rat model to screen drugs that may alter the initial pathological events associated with AD.
Observation of Two Dimensional Spatial Solitary Waves in a Quadratic Medium (1995)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text William E. Torruellas, Lluis Torner, Zuo Wang, David J. Hagan, Eric W. Van Stryland, George I. Stegeman, and Curtis R. Menyuk, "Observation of Two Dimensional Spatial Solitary Waves in a Quadratic Medium," Optics & Photonics News 6(12), 23-24 (1995) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Integrated optical phase locked loop (2011)

A silicon photonics based integrated optical phase locked loop is utilized to synchronize a 10.2 GHz voltage controlled oscillator with a 509 MHz mode locked laser, achieving 32 fs integrated jitter over 300 kHz bandwidth.
Biological activity of avocado‐derived mannoheptulose in dogs (2010)

Mannoheptulose (MH) is a 7‐carbon sugar found in avocados and other natural sources. It is proposed as a calorie restriction (CR) mimetic that delivers anti‐aging and health‐promoting benefits of CR without reducing food intake. Two studies were conducted to evaluate effects of MH on fasting insulin when fed as an avocado extract (AvX) to Labrador Retrievers (LR) and Fox Terriers (FT). Decreased fasting insulin is commonly associated with CR and longevity. In Study 1, 36 dogs, balanced by breed (18 LR; 18 FT) and age (18 young, 2.6 yr; 18 old, 11.8 yr), received control or test treatments during sequential 2‐week periods. Test dogs were fed one AvX‐containing gelatin capsule daily to deliver 1, 2, 10 or 20 mg MH/kg BW in a step‐up fashion. Control dogs were fed one placebo capsule daily. Fasting blood samples were collected weekly. Fasting insulin was lower (P&lt;0.05) in dogs fed 2, 10 and 20 mg/kg. In Study 2, LR (15) and FT (15) were fed an AvX‐containing diet providing 0, 2 or 5 mg MH/kg BW. A glycemic meal challenge was induced on days 0 and 30 by feeding dogs one‐half their daily meal allotment after an overnight fast. Blood samples for insulin and glucose were collected at 0, 30, 60, 120 and 240 min post‐feeding. MH (2 mg/kg) reduced (P&lt;0.05) insulin levels (mean, peak, area under curve) in old LR on day 30. Glucose was not affected by MH. Lower plasma insulin implies mannoheptulose is biologically active in dogs when fed as an avocado extract.
An enhanced switching policy for buck-derived multi-level switching power amplifiers (2010)

This work proposes a switching policy for multi-level full-bridge switching power converters and analyses their performance by driving them with a multi-level PWM modulation, targeting high-efficiency power amplifiers. Unlike conventional policies, which generate the output voltage levels only from the values of the supply voltages, this enhanced policy also uses the values of the voltage difference between supply voltages to generate additional output voltage levels, therefore maximising the number of output voltage levels for a given set of supply voltages and connection switches. Simulation results show that, when tracking a band-limited signal, the proposed switching policy can reduce the power of the high-frequency spectral content from 21% to 11% by upgrading a 5-level amplifier to a 7-level amplifier without adding supply voltages or connection switches.
Towards the use of full covariance models for missing data speaker recognition (2008)

This work investigates the use of missing data techniques for noise robust speaker identification. Most previous work in this field relies on the diagonal covariance assumption in modeling speaker specific characteristics via Gaussian mixture models. This paper proposes the use of full covariance models that can capture linear correlations among feature components. This is of importance for missing data marginalization techniques as they depend on spectral rather than cepstral feature representations. Bounded and complete marginalization schemes are investigated both with diagonal and full covariance mixture models. Speaker identification experiments using stationary and non-stationary noise confirm that full covariance models are indeed superior compared to diagonal models.
Rhodium-Catalyzed Addition of\nArylboronic Acids to Isatins: \nAn Entry to Diversity in\n3-Aryl-3-Hydroxyoxindoles (2016)

A general method for the catalytic 1,2-addition of aryl and alkenyl boronic acids to isatins is described using a rhodium(I)/triphenylphosphite\ncatalyst. The application of this transformation allows the synthesis of a variety of 3-aryl-3-hydroxyoxindole building blocks in high yields. An\nenantioselective version of this reaction using a rhodium(I)/phosphoramidite system is also presented.
On page-based optimistic process checkpointing (2002)

Persistent object systems must provide some form of checkpointing to ensure that changes to persistent data are secured on non-volatile storage. When processes share or exchange modified data, mechanisms must be provided to ensure that they may be consistently checkpointed. This may be performed eagerly by synchronously checkpointing all dependent data. Alternatively, optimistic techniques may be used where processes are individually checkpointed and globally consistent states are found asynchronously. This paper examines two eager checkpointing techniques and describes a new optimistic technique. The technique is applicable in systems such as SASOS, where the notion of process and address space are decoupled.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Dynamic time reversal acoustic focusing of ultrasound for biomedical applications (2013)

Time Reversal Acoustic (TRA) system provides effective focusing in inhomogeneous media that can be used in various biomedical applications including high intensity ultrasound treatment, ultrasound-assisted drug delivery, ultrasonic battery charging of implants, etc. In many cases, the TRA focusing is conducted in tissues with time varied properties and variation in propagating media degrades the TRA focused signal. Dynamic focusing is required to maintain the same acoustic intensity in the focus. We suggest adjustment to the radiated signal in order to maintain the maximal amplitude in the focus using the inverse filtering technique with Tikhonov regularization. The suggested algorithm enables to determine the radiated signal based on the changes in the focused signal received by a beacon. Developed algorithm of TRA refocusing was tested in the experiments with a TRA system with an aluminum reverberator comprising ten piezotransducers with resonance around 1 MHz, DAC control system and a multi-channel binary amplifier. This system was built in Artann Laboratories for investigation of time reversal acoustic focusing for hyperthermia therapy and drug delivery. The dynamic TRA refocusing is shown to be effective even in the case of significant lateral shifts in the media and strong focused signal variation.
Sn doping of (010) β-Ga2O3 films grown by plasma-assisted molecular beam epitaxy (2020)

Sn doping of (010) β-Ga2O3 grown by conventional plasma-assisted molecular beam epitaxy (PAMBE) and via metal oxide catalyzed epitaxy (MOCATAXY) using a supplied indium flux during molecular beam epitaxy (MBE) growth was investigated. While high Sn concentrations were achievable over a range of growth conditions in conventional PAMBE, Sn doping less than 1019 cm−3 resulted in non-uniform doping profiles for constant Sn cell temperatures, as well as run-to-run variation in doping. Sn doping in MOCATAXY grown β-Ga2O3 allowed for sharp doping profiles and a wide range of donor concentrations from 3.9 × 1016 cm−3 to 2 × 1019 cm−3 and a maximum room temperature Hall mobility of 136 cm2/V s at 3.9 × 1016 cm−3. From temperature-dependent Hall measurements, Sn was found to have a relatively deep donor state at 77 meV below the conduction band edge. The samples showed low electron mobility at cryogenic temperatures, suggesting the existence of high background impurity levels in the MBE grown films and the need for impurity control in the oxide MBE growth environment.