gebhart/patrepeval huggingface dataset:
Myocardial Blood Flow and Metabolism in Patients With Hypertrophic Cardiomyopathy (1997)

The underlying pathophysiology of hypertrophic cardiomyopathy (HCM) is still unclear. positron emission tomography is a suitable and promising technique for the detection of possible metabolic consequences of the disease. To assess regional myocardial blood flow and metabolism, 19 asymptomatic or only mildly symptomatic patients with HCM and 10 normal control subjects were studied using carbon-11 acetate and fluorine-18-labelled deoxyglucose (FDG) as tracers of myocardial blood flow (Ao), oxygen consumption (k), and exogenous glucose utilization. In the patients, regional Ao in the hypertrophied septum and apex (H) was similar to that in the nonhypertrophied free wall (N) (91.3 +/- 3.9% vs 92.9 +/- 3.1%; p = NS). However, the k values were significantly lower in H than in N (0.044 +/- 0.012 vs 0.060 +/- 0.016/min, p < 0.0001). The k value in N and normal control subjects (0.062 +/- 0.013) was similar. Postprandial FDG uptake was lower in H than in N (70 +/- 16 vs 91 +/- 7%; p < 0.0001) in 16 patients and slightly higher in 3 patients. Fasting FDG study showed increased FDG uptake in H in 3 out of 13 patients, suggesting a disorder of the myocardial microvascular circulation. A relative decrease in hypertrophied septal and apical oxidative metabolism and glucose utilization without any corresponding perfusion defect could reflect abnormal regional aerobic metabolism in the disproportionately thickened myocardium in patients with HCM. This suggests that a primary myocardial metabolic defect might be present in patients with HCM.
A very high frequency dc-dc converter based on a class &#x03A6;<inf>2</inf> resonant inverter (2008)

This paper introduces a new dc-dc converter suitable for operation at very high frequencies under on-off control. The converter power stage is based on a resonant inverter (the Phi <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> inverter) providing low switch voltage stress and fast settling time. A new multi-stage resonant gate driver suited for driving large, high-voltage rf MOSFETS at VHF frequencies is also introduced. Experimental results are presented from a prototype dc-dc converter operating at 30 MHz at input voltages up to 200 V and power levels above 200 W. These results demonstrate the high performance achievable with the proposed design.
Immunogenicity to Biotherapeutics – The Role of Anti-drug Immune Complexes (2016)

Biological molecules are increasingly becoming a part of the therapeutics portfolio that has been either recently approved for marketing or those that are in the pipeline of several biotech and pharmaceutical companies. This is largely based on their ability to be highly specific relative to small molecules. However, by virtue of being a large protein, and having a complex structure with structural variability arising from production using recombinant gene technology in cell lines, such therapeutics run the risk of being recognized as foreign by a host immune system. In the context of immune-mediated adverse effects that have been documented to biological drugs thus far, including infusion reactions, and the evolving therapeutic platforms in the pipeline that engineer different functional modules in a biotherapeutic, it is critical to understand the interplay of the adaptive and innate immune responses, the pathophysiology of immunogenicity to biological drugs in instances where there have been immune-mediated adverse clinical sequelae and address technical approaches for their laboratory evaluation. The current paradigm in immunogenicity evaluation has a tiered approach to the detection and characterization of anti-drug antibodies (ADAs) elicited in vivo to a biotherapeutic; alongside with the structural, biophysical, and molecular information of the therapeutic, these analytical assessments form the core of the immunogenicity risk assessment. However, many of the immune-mediated adverse effects attributed to ADAs require the formation of a drug/ADA immune complex (IC) intermediate that can have a variety of downstream effects. This review will focus on the activation of potential immunopathological pathways arising as a consequence of circulating as well as cell surface bound drug bearing ICs, risk factors that are intrinsic either to the therapeutic molecule or to the host that might predispose to IC-mediated effects, and review the recent literature on prevalence and intensity of established examples of type II and III hypersensitivity reactions that follow the administration of a biotherapeutic. Additionally, we propose methods for the study of immune parameters specific to the biology of ICs that could be of use in conjunction with the detection of ADAs in circulation.
Custard: Computing Norm States over Information Stores (2016)

Norms provide a way to model the social architecture of a sociotechnical system (STS) and are thus crucial for understanding how such a system supports secure collaboration between principals, that is, autonomous parties such as humans and organizations. Accordingly, an important challenge is to compute the state of a norm instance at runtime in a sociotechnical system. Custard addresses this challenge by providing a relational syntax for schemas of important norm types along with their canonical lifecycles and providing a mapping from each schema to queries that compute instances of the schema in different lifecycle stages. In essence, Custard supports a norm-based abstraction layer over underlying information stores such as databases and event logs. Specifically, it supports deadlines; complex events, including those based on aggregation; and norms that reference other norms.We prove important correctness properties for Custard, including stability (once an event has occurred, it has occurred forever) and safety (a query returns a finite set of tuples). Our compiler generates SQL queries from Custard specifications. Writing out such SQL queries by hand is tedious and error-prone even for simple norms, thus demonstrating Custard's practical benefits.
IVIg to prevent tumor metastases (Review) (2002)

Intravenous gamma globulin (IVIg) is produced from a pool of precipitated IgG from over 3,000 healthy donors. IVIg was originally given to subjects with Igs deficiencies. Later on its beneficial effects on a diverse autoimmune clinical conditions were revealed. Based on large experimental studies in mice as well as limited clinical experience, we consider IVIg useful in preventing metastatic spread. In mice, the employment of IVIg reduced significantly metastatic spread of melanoma, carcinoma and sarcoma. The effect of IVIg was achieved following i.v. or s.c. administration at high dose (2 g/kg body weight) and at 100 times lower doses. The effect of IVIg on the prevention of metastases are diverse and achieved via enhancement of IL-12 secretion and increased NK activity as well as inhibition of matrix metalloproteinase-9 (MMP-9). The lack of serious side effects with the remarkable decrease in metastatic spread make IVIg a suitable adjuvant therapy in early and advanced cancer conditions.
Effect of <em>CYP3A5</em> Polymorphism on Liver Function and Tacrolimus Pharmacokinetics after Conversion to a Once-Daily Tacrolimus Formulation in Stable Liver Transplant Patients (2020)

To analyze the effects of CYP3A5 polymorphism on liver function after LT and to characterize the pharmacokinetics of tacrolimus after conversion from a twice-daily regimen to a once-daily extended-release formulation. A prospective open-label study included 60 stable liver transplant recipients who underwent 1:1 conversion from twice-daily tacrolimus to once-daily tacrolimus. All participants were genotyped for CYP3A5 polymorphism. The study was registered at ClinicalTrials.gov (NCT 02882113). Twenty-eight patients were enrolled in the CYP3A5 expressor group and 32 in the non-expressor group. Although there was no statistical difference, incidence of liver dysfunction was higher in the expressor group than in the non-expressor group when converted to once-daily extended-release tacrolimus (P=0.088). No biopsy-proven acute rejection, graft failure, and mortality were observed in either group. The decrease in dose-adjusted trough level (- 42.9% vs. - 26.1%) and dose/kg-adjusted trough level of tacrolimus (- 40.0% vs. - 23.7%) was significantly greater in the expressor group than in the non-expressors after the conversion. The absorption of the tacrolimus in the non-expressor group was slower than in the expressors. In line with this observation, the AUC for once-daily tacrolimus correlated with Cmin in the non-expressors and Cmax in the expressors. Determination of CYP3A5 genotype in liver transplant recipients might be helpful in prediction of tacrolimus pharmacokinetics after conversion from a twice-daily regimen to a once-daily formulation.
Motion invariant imaging by means of focal sweep (2011)

In this paper we evaluate a so-called “sweeping focus camera” of which the camera blur is insensitive to the actual distance to the objects and to the direction and magnitude of the velocities within a scene. This can be achieved by either moving the sensor linearly along the optical axis of the main lens or changing the focal length of the main lens while the shutter is open. A consistently sharp image can then be obtained by the application of a fixed inverse filter kernel, thus preventing the need for depth and motion estimation. Moreover, high frequencies are better preserved during the acquisition, such that the results achieved by inverse filtering are superior to those achievable with conventional shutter/sensor operations.
Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331 (2000)

Uracil DNA misincorporation and misrepair of DNA have been recognized as important events accompanying thymidylate synthase (TS) inhibition. dUTPase catalyses the hydrolysis of dUTP to dUMP, thereby maintaining low intracellular dUTP. We have addressed the relationship between dUTPase expression and cellular sensitivity to TS inhibition in four human lung tumour cell lines. Sensitivity (5-day MTT assay) to the growth inhibitory effects of the non-polyglutamatable, specific quinazoline TS inhibitor ZD9331, varied up to 20-fold (IC(50)3-70 nM). TS protein expression correlated with TS activity (r(2)= 0.88, P = 0.05). Intracellular concentrations of drug following exposure to ZD9331 (1 microM, 24 h) varied by approximately 2-fold and dTTP pools decreased by > 80% in all cell lines. No clear associations across the cell lines between intracellular drug concentrations, TS activity/expression, or TTP depletion could be made. dUTPase activity varied 17-fold and correlated with dUTPase protein expression (r(2)= 0.94, P = 0.03). There was a striking variation in the amount of dUTP formed following exposure to ZD9331 (between 1.3 and 57 pmole 10(-6)cells) and was in general inversely associated with dUTPase activity. A large expansion in the dUTP pool was associated with increased sensitivity to a 24-h exposure to ZD9331 in A549 cells that have low dUTPase activity/expression. dUTPase expression and activity were elevated (approximately 3-fold) in two variants of a human lymphoblastoid cell line with acquired resistance to TS inhibitors, further suggesting an important role for this enzyme in TS inhibited cells.
ChemInform Abstract: Synthesis of Subunits of Marine Polycyclic Ethers by Ring‐Closing Metathesis and Hydroboration of Enol Ethers. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
AutoBayes: Automated Inference via Bayesian Graph Exploration for Nuisance-Robust Biosignal Analysis. (2020)

Learning data representations that capture task-related features, but are invariant to nuisance variations remains a key challenge in machine learning, in particular for biosignal processing. We introduce an automated Bayesian inference framework, called AutoBayes, that explores different graphical models linking classifier, encoder, decoder, estimator and adversary network blocks to optimize nuisance-invariant machine learning pipelines. AutoBayes also enables justifying disentangled representation, which splits the latent variable into multiple pieces to impose different relation with subject/session-variation and task labels. We benchmark the framework on a series of physiological datasets, where we have access to subject and class labels during training, and provide analysis of its capability for subject transfer learning with/without variational modeling and adversarial training. The framework can be effectively utilized in semi-supervised multi-class classification, and reconstruction tasks for datasets in different domains as well.
Secondary Structure (2016)

In the past, aggregation and self-assembly have been associated principally with micellar and colloidal systems of molecules; however, with the advent of supramolecular chemistry, molecular self-assembly has been opened to a much wider understanding that has facilitated access to a variety of different shapes and sizes, along with the construction of new and fascinating molecular topologies. This document aims at defining more than 150 terms related to aggregation and self-assembly in the particular case of macromolecules. The list is restricted to the most commonly encountered terms.
ChemInform Abstract: Cytotoxic, Antifouling Bromotyramines: A Synthetic Study on Simple Marine Natural Products and Their Analogues. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Acute Kidney Injury Electronic Alert for Nephrologist: Reactive versus Proactive? (2016)

Acute kidney injury (AKI) is a common complication of acute illnesses with significant impact on the mortality and morbidity. Early recognition of AKI allows clinicians to provide prophylactic interventions and to improve the outcomes of this deadly syndrome. Growing utilization and capabilities of electronic health records allow AKI risk stratification and early recognition with a potential effect on the processes of care and outcomes. We evaluate the current level of evidence on the impact of the AKI e-alert on the processes of care and outcomes. We then discuss the impacts of e-alerting in the design of the future of nephrology service within the hospital practices with suggestions regarding the role of nephrologists in management of AKI e-alert systems in order to improve the quality of care provided to AKI patients. Video Journal Club 'Cappuccino with Claudio Ronco' at http://www.karger.com/?doi=450722.
Enantiomeric Natural Products: Occurrence and Biogenesis (2012)

In nature, chiral natural products are usually produced in optically pure form-however, occasionally both enantiomers are formed. These enantiomeric natural products can arise from a single species or from different genera and/or species. Extensive research has been carried out over the years in an attempt to understand the biogenesis of naturally occurring enantiomers; however, many fascinating puzzles and stereochemical anomalies still remain.
Preface (2003)

ADVERTISEMENT RETURN TO BOOKPREVPrefaceNEXTPrefaceRobin D. RogersRobin D. RogersCenter for Green Manufacturing Box 870336 The University of Alabama Tuscaloosa, AL 35487 Telephone: +1 205-348-4323 Fax: +1 205-348-0823 Email: [email protected] URL: http://bama.ua.edu/~rdrogersMore by Robin D. Rogers and Kenneth R. SeddonKenneth R. SeddonQUILL Research Centre The Queen's University of Belfast Stranmillis Road Belfast, Northern Ireland BT9 5AG United Kingdom Telephone: +44 28 90335420 Fax: +44 28 90665297 Email: [email protected] URL: http://quill.qub.ac.uk/More by Kenneth R. SeddonDOI: 10.1021/bk-2003-0856.pr001 This publication is free to access through this site. Learn MorePublication Date (Print):August 26, 2003Publication History Published online23 July 2009Published inprint 26 August 2003Request reuse permissions Copyright © 2003 American Chemical Society. This publication is available under these Terms of Use. Ionic Liquids as Green Solventspp xiii-xviACS Symposium SeriesVol. 856ISBN13: 9780841238565eISBN: 9780841219618Chapter Views495Citations2LEARN ABOUT THESE METRICSChapter Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (595 KB) Get e-Alerts
ORIGINAL ARTICLE: LPS‐Induced Murine Abortions Require C5 but not C3, and are Prevented by Upregulating Expression of the CD200 Tolerance Signaling Molecule (2008)

C5, but not C3, appears necessary for LPS-driven abortions. Up-regulation of CD200 can prevent LPS-driven abortions, possibly by altering dendritic cells to promote Treg cell development or by a direct suppressive action on macrophages and mast cells that also express CD200 receptors.
Experimental investigation of bifurcation induced bandgap reconfiguration (2014)

By applying an asymmetric on-site restoring force in a 1D chain of oscillators, we demonstrate experimentally that a morphing in the bandgap structure or passive bandgap reconfiguration can be triggered by an increase in environmental excitation amplitude. Recent studies on wave propagation have focused on new capabilities and behaviors resulting from intrinsic nonlinearities. This paper details a bistable experimental design that achieves amplitude dependent filtering through passive bandgap reconfiguration, which is triggered by a bifurcation. The system studied comprises a 1D chain of axially aligned pendulums in dimer unit cells with geometrically nonlinear nearest neighbor coupling where bistability is induced through repulsive magnets. When the bistability is asymmetric, each potential well has a different linear spectra. Though this paper uses mechanically coupled oscillators as an example, the phenomenon itself could be used in any wave propagation media where asymmetric bistability can be implemented.
Multidrug resistance gene (MDR1) expression in human brain tumors (1991)

Multidrug resistance for many types of cancer outside the central nervous system (CNS) has been found to be due to the overexpression of the multidrug resistance gene MDR1, of which the gene-product P-glycoprotein acts as a membrane-bound efflux pump for many anticancer drugs. To examine whether brain tumors overexpress the MDR1 gene, 25 brain-tumor specimens were subjected to Northern blot analysis: 10 gliomas, eight meningiomas, three schwannomas, one malignant lymphoma, and three tumors metastatic to the brain. Ten fresh-frozen autopsy specimens of various parts of normal brain were also analyzed. Blots were hybridized with 32P-labeled Chinese hamster complementary deoxyribonucleic acid (cDNA) and 32P-labeled human MDR1 cDNA. The MDR1 gene messenger ribonucleic acid (mRNA) was detected in two tumors using the Chinese hamster probe (one sphenoid wing meningioma and one metastatic prostate tumor) and in one CNS lymphoma using the human probe. Intact mRNA could not be extracted from the fresh-frozen autopsy specimens of normal brain. Seventeen tumors were examined for P-glycoprotein by immunohistochemical staining using murine monoclonal antibody C219: eight gliomas, eight meningiomas, and one craniopharyngioma. The neoplastic cells from two gliomas and three meningiomas and the blood vessels within six gliomas and two meningiomas stained positively for P-glycoprotein. Seven of 10 normal brain specimens stained positively for P-glycoprotein in blood vessels but no specimen demonstrated staining of parenchymal cells. This study demonstrates that the MDR1 gene can be detected in normal brain, and in malignant, benign, and metastatic lesions. P-glycoprotein can be present in tumor blood vessels even when it is not seen in neoplastic cells. Although the role of P-glycoprotein in tumor blood vessels needs to be further examined and more clearly defined, drug resistance in malignant primary brain tumors may result from characteristics not solely of neoplastic cells but also tumor vasculature.
Posttranscriptional regulation of oligodendroglial thyroid hormone (T3) receptor β1 by T3 (1998)

3,5,3'-triiodo-L-thyronine interacts with the genome by binding and activating nuclear 3,5,3'-triiodo-L-thyronine receptors. To determine how in secondary oligodendrocyte cultures, exogenous 3,5,3'-triiodo-L-thyronine influences the expression of different 3,5,3'-triiodo-L-thyronine receptor isoforms, we studied the regulation of alpha 1, alpha 2 and beta 1 3,5,3'-triiodo-L-thyronine receptor mRNAs. In culture, we find that beta 1, 3,5,3'-triiodo-L-thyronine receptor mRNA, but not alpha 1 and alpha 2 3,5,3'-triiodo-L-thyronine receptor mRNAs, is up-regulated by 3,5,3'-triiodo-L-thyronine in a time and dose dependent manner. In addition, we present evidence indicating that beta 1 3,5,3'-triiodo-L-thyronine receptor expression is posttranscriptionally regulated by 3,5,3'-triiodo-L-thyronine. Previous studies from our laboratory and others have shown that in the rat oligodendrocyte lineage, 3,5,3'-triiodo-L-thyronine receptors alpha 1 and alpha 2 were expressed in both early progenitor cells and mature oligodendrocytes. In contrast, beta 1 3,5,3'-triiodo-L-thyronine receptor was found to be expressed only in mature oligodendrocytes. This suggests that thyroid hormone may influence oligodendrocyte differentiation and maturation via 3,5,3'-triiodo-L-thyronine receptor beta 1, which is expressed only in oligodendrocytes and not in progenitor cells. We therefore show that this effect is indirect and is mediated by 3,5,3'-triiodo-L-thyronine which acts posttranscriptionally on the 3,5,3'-triiodo-L-thyronine receptor beta 1 gene.