gebhart/patrepeval huggingface dataset:
Nonlinear Dynamics of an Imperfect Microbeam Under an Axial Load and Electric Excitation (2011)

This study is motivated by the growing attention, both from a practical and a theoretical point of view, toward the nonlinear behavior of microelectromechanical systems (MEMS). We analyze the nonlinear dynamics of an imperfect microbeam under an axial force and electric excitation. The imperfection of the microbeam, typically due to microfabrication processes, is simulated assuming the microbeam to be of a shallow arched initial shape. The device has a bistable static behavior. The aim is that of illustrating the nonlinear phenomena, which arise due to the coupling of mechanical and electrical nonlinearities, and discussing their usefulness for the engineering design of the microstructure. We derive a single-mode-reduced-order model by combining the classical Galerkin technique and the Pade´ approximation. Despite its apparent simplicity, this model is able to capture the main features of the complex dynamics of the device. Extensive numerical simulations are performed using frequency response diagrams, attractor-basins phase portraits, and frequency-dynamic voltage behavior charts. We investigate the overall scenario, up to the inevitable escape, obtaining the theoretical boundaries of appearance and disappearance of the main attractors. The main features of the nonlinear dynamics are discussed, stressing their existence and their practical relevance. We focus on the coexistence of robust attractors, which leads to a considerable versatility of behavior. This is a very attractive feature in MEMS applications. The ranges of coexistence are analyzed in detail, remarkably at high values of the dynamic excitation, where the penetration of the escape (dynamic pull-in) inside the double well may prevent the safe jump between the attractors.
Supplementary Figure 1 from Treatment-Dependent Androgen Receptor Mutations in Prostate Cancer Exploit Multiple Mechanisms to Evade Therapy (2023)

Supplementary Figure 1 from Treatment-Dependent Androgen Receptor Mutations in Prostate Cancer Exploit Multiple Mechanisms to Evade Therapy
Decreased Colony‐Forming Ability of Subacromial Bursa‐Derived Cells During Revision Arthroscopic Rotator Cuff Repair (2021)

The subacromial bursa may play a role in the healing response of the repaired rotator cuff. This capacity is not necessarily diminished in the revision setting and may be harnessed as an orthobiologic.
Industry forum: IoT for real life part II (2016)

Start of the above-titled section of the conference proceedings record.
Ophthalmic Laser Therapy and Surgery (2021)

Modern ophthalmic lasers enable unprecedented precision and selectivity in many therapeutic and surgical procedures and have become indispensable for ophthalmic care. Lasers enable exquisitely precise spatial and temporal control of the light delivery to tissue, which can enact a wide variety of interaction mechanisms, including photo-chemical, photo-thermal, photo-mechanical, and photo-ionization. A broad range of wavelengths and pulse durations provide excellent means for very selective interactions with the target tissue. Progress in understanding of the laser-tissue interactions and the tissue response pathways leads to more selective and less damaging treatments, such as minimally traumatic photocoagulation which utilizes retinal plasticity to minimize scarring; selective treatment of retinal pigment epithelium (selective RPE therapy) and trabecular epithelium (selective laser trabeculoplasty) based on intracellular explosion of melanosomes using microsecond and nanosecond pulses; and non-damaging laser therapy of the macula (non-damaging retinal laser therapy) using transient hyperthermia below damage threshold. As technology advances, manual treatments have been replaced with more automated pre-planned image-guided procedures, including patterned laser therapy of the retina and of trabecular meshwork, as well as refractive and cataract surgeries based on ultra-fast lasers.
Abstract 5512: Immune correlates of clinical response and survival in castration-resistant prostate cancer patients treated with prostate GVAX and anti-CTLA4 immunotherapy (2011)

Abstract The effects of Prostate GVAX and the anti-CTLA4 antibody Ipilimumab were investigated in a Phase I dose escalation/expansion trial of patients with castration resistant prostate cancer. Results showed that the GVAX/Ipilimumab combination was clinically active with PSA declines of more than 50% (Partial Response, PR) in 6 and PSA stabilizations (Stable Disease, SD) in 11 of 28 patients. Immune response monitoring was performed to identify changes that might predict or correlate with clinical efficacy. Upon administration of high Ipilimumab dosages (3 or 5 mg/kg), significant increases in frequencies of activated CD4+ and/or CD8+ T cells were observed by HLA-DR, PD-1, FoxP3 and ICOS expression. Monitoring over the course of treatment, revealed these markers to be differentially associatied with survival, as were levels of effector/memory T cells or Tregs. Early HLA-DR upregulation appeared useful as a marker for response prediction, since it was observed to significant levels in PR or SD, but not in PD patients. In addition, GVAX/Ipilimumab administration was found to induce Th2/Th17 cytokine profiles, as determined ex vivo by intracellular staining of peripheral T cells. Significantly increased levels of IL-4 in both CD4+ and CD8+ T cells were observed in patients with PR or SD, but not in patients with PD and, importantly, profound up-regulation of CD4+IL-5+ T cell frequencies was associated with improved overall survival (p=0.03). Similarly, significantly increased Th17 rates were only observed in patients with PR and SD (p&amp;lt;0.05). Of particular interest, the increased Th17 frequencies coincided with onset of hypophysitis and/or adrenal insufficiencies, as well as of PSA declines in PR patients. As an indication of tumor-specific responsiveness, IgG antibody responses against 11 (prostate) tumor-associated antigens were determined by western blot and ELISA. Increased seroreactivity to prostate-specific membrane antigen (PSMA), pyridoxamine 5′-phosphate oxidase (PNPO) and/or Neuropilin-2 (NRP2) was significantly correlated with improved overall survival (p&amp;lt;0.03). Our data indicate that changes in frequencies of activated memory/effector T cells and Tregs, Th2 and Th17 rates and seroconversion to multiple tumor antigens may define a predictive immune profile for patients with potential benefit from Prostate GVAX and/or anti-CTLA4 immunotherapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5512. doi:10.1158/1538-7445.AM2011-5512
Cylindrical Antenna Arrays for WCDMA Downlink Capacity Enhancement (2006)

Advanced antenna arrays at the base stations are one of the key techniques to improve the downlink capacity of WCDMA cellular systems. Traditionally, linear and circular arrays are used to form the beams. In this paper, cylindrical antenna arrays with various types of input excitations are proposed, and the beam steering adaptive antenna technique is considered. The user capacity per cell among the linear, circular, and cylindrical arrays is presented and compared in a simulation environment supporting various types of adaptive antennas, soft/softer handover, and multiple services. A notable superiority of the proposed cylindrical antenna arrays was demonstrated by the simulation results.
Blue Electroluminescent 1,2,4-Triazole Derivative (1996)

Abstract A blue fluorescent 1,2,4-triazole derivative, DA-TAZ, was synthesized and exmined as an emitter layer in organic electroluminescent device. The device structure of glass substrate / indium-tin oxide / hole-transporting diamine layer / DA-TAZ layer / Mg:Ag was employed. The EL device exhibited bright blue light originating from the DA-TAZ emitter layer with a maximum luminance of 1200 cd/m2 at 14 volt.
Lipoarabinomannan Localization and Abundance during Growth of Mycobacterium smegmatis (2011)

Lipoarabinomannan (LAM) is a structurally heterogeneous amphipathic lipoglycan present in Mycobacterium spp. and other actinomycetes, which constitutes a major component of the cell wall and exhibits a wide spectrum of immunomodulatory effects. Analysis of Mycobacterium smegmatis subcellular fractions and spheroplasts showed that LAM and lipomannan (LM) were primarily found in a cell wall-enriched subcellular fraction and correlated with the presence (or absence) of the mycolic acids in spheroplast preparations, suggesting that LAM and LM are primarily associated with the putative outer membrane of mycobacteria. During the course of these studies significant changes in the LAM/LM content of the cell wall were noted relative to the age of the culture. The LAM content of the M. smegmatis cell wall was dramatically reduced as the bacilli approached stationary phase, whereas LM, mycolic acid, and arabinogalactan content appeared to be unchanged. In addition, cell morphology and acid-fast staining characteristics showed variations with growth phase of the bacteria. In the logarithmic phase, the bacteria were found to be classic rod-shaped acid-fast bacilli, while in the stationary phase M. smegmatis lost the characteristic rod shape and developed a punctate acid-fast staining pattern with carbolfuchsin. The number of viable bacteria was independent of LAM content and phenotype. Taken together, the results presented here suggest that LAM is primarily localized with the mycolic acids in the cell wall and that the cellular concentration of LAM in M. smegmatis is selectively modulated with the growth phase.
Copper induces cell death by targeting lipoylated TCA cycle proteins (2022)

Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How excess copper induces cell death, however, is unknown. Here, we show in human cells that copper-dependent, regulated cell death is distinct from known death mechanisms and is dependent on mitochondrial respiration. We show that copper-dependent death occurs by means of direct binding of copper to lipoylated components of the tricarboxylic acid (TCA) cycle. This results in lipoylated protein aggregation and subsequent iron-sulfur cluster protein loss, which leads to proteotoxic stress and ultimately cell death. These findings may explain the need for ancient copper homeostatic mechanisms.
Towards Quality Assessment of Crowdworker Output Based on Behavioral Data (2019)

In this paper, we show preliminary results on the quality assessment of crowdworker output based on the movements of the mouse and the eyes while the task is performed. We assume that the mouse and the eyes stop longer if the quality is lower due to the lack of knowledge, or confidence, etc. Because the mouse- and eye-stopping duration follows lognormal distribution, we estimate its parameters (mean and standard deviation) to evaluate the quality. Results of preliminary experiments with 10 participants show that the parameters of correct outputs are different from those of incorrect ones. As compared to the task duration, which is often used as a feature for assessment, we have found that the mouse-and the eyestopping duration is advantageous and complementary for the assessment.
Electric resonance-rectifier circuit for renewable energy conversion (2012)

Variable speed generators are used more frequently for converting the energy from renewable energy sources to electric energy. The power production form a variable speed generator is dependent on the electrical damping of the generator. In this paper, a resonance circuit connected to a direct driven linear generator used for wave energy utilization is investigated. At resonance, the electrical damping in the generator increases which results in an increased power production. The results show that resonance can be achieved with the suggested circuit.
Data from Patients with Slowly Proliferative Early Breast Cancer Have Low Five-Year Recurrence Rates in a Phase III Adjuvant Trial of Capecitabine (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; We conducted a randomized phase III study to determine whether patients with early breast cancer would benefit from the addition of capecitabine (X) to a standard regimen of doxorubicin (A) plus cyclophosphamide (C) followed by docetaxel (T).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Treatment comprised eight cycles of AC→T (T dose: 100 mg/m&lt;sup&gt;2&lt;/sup&gt; on day 1) or AC→XT (X dose: 825 mg/m&lt;sup&gt;2&lt;/sup&gt; twice daily, days 1–14; T dose: 75 mg/m&lt;sup&gt;2&lt;/sup&gt; on day 1). The primary endpoint was 5-year disease-free survival (DFS).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Of 2,611 women, 1,304 were randomly assigned to receive AC→T and 1,307 to receive AC→XT. After a median follow-up of 5 years, the study failed to meet its primary endpoint [HR, 0.84; 95% confidence interval (CI), 0.67–1.05; &lt;i&gt;P&lt;/i&gt; = 0.125]. A significant improvement in overall survival, a secondary endpoint, was seen with AC→XT versus AC→T (HR, 0.68; 95% CI, 0.51–0.92; &lt;i&gt;P&lt;/i&gt; = 0.011). There were no unexpected adverse events. Of patients with estrogen receptor (ER)–positive/HER2-negative disease, 70% of whom were node-positive, 26% and 59% had tumors with a centrally assessed Ki-67 score of &lt;10% or &lt;20%, respectively, and only 17 (2%) and 53 (6%) DFS events, respectively, occurred in these groups at 7 years.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; The very low event rate in patients with ER-positive, low Ki-67 cancers, regardless of nodal status, strongly suggests that these patients should not be enrolled in adjuvant trials that assess 5-year DFS rates and that central Ki-67 analyses can identify these patients. &lt;i&gt;Clin Cancer Res; 21(19); 4305–11. ©2015 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Fabrication and Characterisation of a Photo-Responsive, Injectable Nanosystem for Sustained Delivery of Macromolecules (2021)

The demand for biodegradable sustained release carriers with minimally invasive and less frequent administration properties for therapeutic proteins and peptides has increased over the years. The purpose of achieving sustained minimally invasive and site-specific delivery of macromolecules led to the investigation of a photo-responsive delivery system. This research explored a biodegradable prolamin, zein, modified with an azo dye (DHAB) to synthesize photo-responsive azoprolamin (AZP) nanospheres loaded with Immunoglobulin G (IgG). AZP nanospheres were incorporated in a hyaluronic acid (HA) hydrogel to develop a novel injectable photo-responsive nanosystem (HA-NSP) as a potential approach for the treatment of chorio-retinal diseases such as age-related macular degeneration (AMD) and diabetic retinopathy. AZP nanospheres were prepared via coacervation technique, dispersed in HA hydrogel and characterised via infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA). Size and morphology were studied via scanning electron microscopy (SEM) and dynamic light scattering (DLS), UV spectroscopy for photo-responsiveness. Rheological properties and injectability were investigated, as well as cytotoxicity effect on HRPE cell lines. Particle size obtained was <200 nm and photo-responsiveness to UV = 365 nm by decreasing particle diameter to 94 nm was confirmed by DLS. Encapsulation efficiency of the optimised nanospheres was 85% and IgG was released over 32 days up to 60%. Injectability of HA-NSP was confirmed with maximum force 10 N required and shear-thinning behaviour observed in rheology studies. In vitro cell cytotoxicity effect of both NSPs and HA-NSP showed non-cytotoxicity with relative cell viability of ≥80%. A biocompatible, biodegradable injectable photo-responsive nanosystem for sustained release of macromolecular IgG was successfully developed.
ENDOR study of a one-electron 2:18 reduced fluoropolytungstate (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTENDOR study of a one-electron 2:18 reduced fluoropolytungstateD. Gourier, P. Doppelt, and C. SanchezCite this: Inorg. Chem. 1986, 25, 25, 4462–4464Publication Date (Print):December 1, 1986Publication History Published online1 May 2002Published inissue 1 December 1986https://pubs.acs.org/doi/10.1021/ic00245a004https://doi.org/10.1021/ic00245a004research-articleACS PublicationsRequest reuse permissionsArticle Views18Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Upper critical solution temperature thermo-responsive polymer brushes and a mechanism for controlled cell attachment (2017)

We report the synthesis of thermo-responsive polymer brushes with Upper Critical Solution Temperature (UCST)-type behaviour on glass to provide a new means to control cell attachment. Thermoresponsive poly(N-acryloyl glycinamide)-stat-poly(N-phenylacrylamide) (PNAGAm-PNPhAm) brushes with three different monomer ratios were synthesized to give tunable phase transition temperatures (T<sub>p</sub>) in solution. Surface energies of surface-grafted brushes of these polymers at 25, 32, 37 and 50 °C were calculated from contact angle measurements and atomic force microscopy (AFM) studies confirmed that these polymers were highly extended at temperatures close to T<sub>p</sub> in physiologically-relevant media. Importantly, NIH-3T3 cells were attached on the collapsed PNAGAm-PNPhAm brush surface at 30 °C after 20 h incubation, while release of cells from the extended brushes was observed within 2 h after the culture temperature was switched to 37 °C. Furthermore, the changes in cell attachment followed changes in the Lewis base component of surface energy. The results indicate that, in contrast to the established paradigm of enhanced cell attachment to surfaces where polymers are above a Lower Critical Solution Temperature (LCST), these novel substrates enable detachment of cells from surfaces at temperatures above a UCST. In turn these responsive materials open new avenues for the use of polymer-modified surfaces to control cell attachment for applications in cell manufacture and regenerative medicine.
Assessment of the exhalation kinetics of volatile cancer biomarkers based on their physicochemical properties (2014)

The current review provides an assessment of the exhalation kinetics of volatile organic compounds (VOCs) that have been linked with cancer. Towards this end, we evaluate various physicochemical properties, such as 'breath:air' and 'blood:fat' partition coefficients, of 112 VOCs that have been suggested over the past decade as potential markers of cancer. With these data, we show that the cancer VOC concentrations in the blood and in the fat span over 12 and 8 orders of magnitude, respectively, in order to provide a specific counterpart concentration in the exhaled breath (e.g., 1 ppb). This finding suggests that these 112 different compounds have different storage compartments in the body and that their exhalation kinetics depends on one or a combination of the following factors: (i) the VOC concentrations in different parts of the body; (ii) the VOC synthesis and metabolism rates; (iii) the partition coefficients between tissue(s), blood and air; and (iv) the VOCs' diffusion constants. Based on this analysis, we discuss how this knowledge allows modeling and simulating the behavior of a specific VOC under different sampling protocols (with and without exertion of effort). We end this review by a brief discussion on the potential role of these scenarios in screening and therapeutic monitoring of cancer.
Model Combination for Machine Translation (2010)

Machine translation benefits from two types of decoding techniques: consensus decoding over multiple hypotheses under a single model and system combination over hypotheses from different models. We present model combination, a method that integrates consensus decoding and system combination into a unified, forest-based technique. Our approach makes few assumptions about the underlying component models, enabling us to combine systems with heterogenous structure. Unlike most system combination techniques, we reuse the search space of component models, which entirely avoids the need to align translation hypotheses. Despite its relative simplicity, model combination improves translation quality over a pipelined approach of first applying consensus decoding to individual systems, and then applying system combination to their output. We demonstrate BLEU improvements across data sets and language pairs in large-scale experiments. 1
Perifosine as a potential novel anti-telomerase therapy (2015)

Most tumors circumvent telomere-length imposed replicative limits through expression of telomerase, the reverse transcriptase that maintains telomere length. Substantial evidence that AKT activity is required for telomerase activity exists, indicating that AKT inhibitors may also function as telomerase inhibitors. This possibility has not been investigated in a clinical context despite many clinical trials evaluating AKT inhibitors. We tested if Perifosine, an AKT inhibitor in clinical trials, inhibits telomerase activity and telomere maintenance in tissue culture and orthotopic xenograft models as well as in purified CLL samples from a phase II Perifosine clinical trial. We demonstrate that Perifosine inhibits telomerase activity and induces telomere shortening in a wide variety of cell lines in vitro, though there is substantial heterogeneity in long-term responses to Perifosine between cell lines. Perifosine did reduce primary breast cancer orthotopic xenograft tumor size, but did not impact metastatic burden in a statistically significant manner. However, Perifosine reduced telomerase activity in four of six CLL patients evaluated. Two of the patients were treated for four to six months and shortening of the shortest telomeres occurred in both patients' cells. These results indicate that it may be possible to repurpose Perifosine or other AKT pathway inhibitors as a novel approach to targeting telomerase.