gebhart/patrepeval huggingface dataset:
Search for direct top squark pair production in events with a Higgs or Z boson, and missing transverse momentum in s = 13 $$ \sqrt{s}=13 $$ TeV pp collisions with the ATLAS detector (2017)

A search for direct top squark pair production resulting in events with either a same-flavour opposite-sign dilepton pair with invariant mass compatible with a $Z$ boson or a pair of jets compatible with a Standard Model (SM) Higgs boson ($h$) is presented. Requirements on additional leptons, jets, jets identified as originating from $b$-quarks, and missing transverse momentum are imposed to target the other decay products of the top squark pair. The analysis is performed using proton-proton collision data at $\sqrt{s}=13$ TeV collected with the ATLAS detector at the LHC in 2015--2016, corresponding to an integrated luminosity of 36.1 fb$^{-1}$. No excess is observed in the data with respect to the SM predictions. The results are interpreted in two sets of models. In the first set, direct production of pairs of lighter top squarks ($\tilde{t}_1$) with long decay chains involving $Z$ or Higgs bosons is considered. The second set includes direct pair production of the heavier top squark pairs ($\tilde{t}_2$) decaying via $\tilde{t}_2 \rightarrow Z \tilde{t}_1 $ or $\tilde{t}_2 \rightarrow h \tilde{t}_1$. The results exclude at 95\% confidence level $\tilde{t}_2$ and $\tilde{t}_1$ masses up to about 800 GeV, extending the exclusion region of supersymmetric parameter space covered by previous LHC searches.
Building a distributed key-value store with FPGA-based microservers (2015)

Energy efficiency is one of the major challenges in datacenters, and a promising way to tackle it are microservers. These scaled down machines with smaller CPUs, less peripherals and tighter integration improve energy efficiency, but often at the expense of lower performance. In this work we explore the tailoring of standard software components to specialized hardware as a way to get the energy efficiency of microservers without compromising performance. Our specialized microserver implements memcached, a common component in many web stacks, on a cluster of FPGAs. The design explores aspects such as pipelining techniques, tight integration with the network stack, dealing with the memory bottleneck, and shows how to build a complete system out of individual microservers. To our knowledge this is the first stand-alone FPGA-based solution that can be used as a drop-in replacement for the software version. Beyond the per-node performance, in this demo we focus on the replication and the integration aspects of our system. We run a common benchmark on a PostgreSQL database with a two-node deployment of FPGAs acting as a cache for query results.
Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones (2021)

Eukaryotic DNA replication initiates during S phase from origins that have been licensed in the preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2, Orc3, Mcm3, and Mcm7 with gene expression, replication timing, and fork directionality profiles obtained by RNA-seq, Repli-seq, and OK-seq. Both, the origin recognition complex (ORC) and the minichromosome maintenance complex (MCM) are significantly and homogeneously depleted from transcribed genes, enriched at gene promoters, and more abundant in early- than in late-replicating domains. Surprisingly, after controlling these variables, no difference in ORC/MCM density is detected between initiation zones, termination zones, unidirectionally replicating regions, and randomly replicating regions. Therefore, ORC/MCM density correlates with replication timing but does not solely regulate the probability of replication initiation. Interestingly, H4K20me3, a histone modification proposed to facilitate late origin licensing, was enriched in late-replicating initiation zones and gene deserts of stochastic replication fork direction. We discuss potential mechanisms specifying when and where replication initiates in human cells.
InP-Based Type-II Heterostructure Lasers for Wavelength above 2 &#x00B5;m (2014)

We present an innovative concept for InP-based lasers utilizing the type-II band alignment between GaAsSb and GaInAs. With W-shaped QWs spontaneous room temperature emission up to 3.9 μm and lasing up to 2.6 μm could be demonstrated.
Investigation of Different Nano Scale Energetic Material Systems for Reactive Wafer Bonding (2013)

This paper introduces a method that uses a specific form of local heat generation, which is based on nano scale reactive multilayer systems. Such systems consist of several layers of minimum two different materials with nano scale thicknesses. These layers generate heat based on a self-propagating exothermic reaction during their intermixing. The resulting heat can be used as heat source for bonding processes at chip and wafer-level.
Tensile and compressive strain in GaInP lasers at 637 nm: the role of the sublinear gain-current relationship (2002)

Measured threshold currents of tensile and compressively strained lasers show that differences between 637 nm devices are due chiefly to the internal mode loss and recombination current rather than gain saturation in thin compressively strained structures.
Autoantibodies against a specific nuclear RNP protein in sera of patients with autoimmune rheumatic diseases associated with myositis. (1987)

Polymyositis is an autoimmune, inflammatory disease affecting human skeletal muscle. In the presence of concomitant vasculitis in the skin, the term dermatomyositis is used. In contrast, systemic lupus erythematosus (SLE) is a multisystem disease in which involvement of the skin, kidneys, joints, brain, and other organs may be found. The clinical manifestations vary according to the organ/system involved. It is clinical and therapeutic importance to define which organ/system is involved during the course of the disease. We approached this problem by studying the specificity of autoantibodies that are generated in patients with SLE and polymyositis/dermatomyositis. Among such antibodies are those directed against nuclear components including a variety of ribonucleoprotein (RNP) complexes. We have utilized mammalian nuclear preparations enriched with RNP particles as the antigenic source for immunoblotting studies to identify specific antigenic polypeptides. In the study reported here, sera from five groups of patients were examined: 10 patients with dermatomyositis/polymyositis; six patients with SLE and myositis; 12 lupus patients with cerebral and/or renal disease; eight patients with SLE but no myositis, renal, or cerebral disease; and 5) 11 patients with muscle weakness or muscle disease not due to myositis. In the first two groups of patients with myositis, antibodies against a nuclear RNP protein of 56 KD was identified in 12 of 16 sera. In contrast, such antibodies were found in the serum of only two of 20 patients with SLE but without muscle involvement (groups 3 and 4), and were not found at all in patients with other muscle diseases. This study has identified a new marker, antibodies against a nuclear RNP protein of 56 KD for detecting muscle involvement among the autoimmune rheumatic diseases.
An assay for botulinum toxin types A, B and F that requires both functional binding and catalytic activities within the neurotoxin (2009)

The EARB assay system described is the first convenient in vitro assay system described which is requires multiple functional biological activities with the BoNTs. The assay will have applications in instances where it is essential or desirable to distinguish biologically active from inactive neurotoxin.
LLC DC-DC Converter with Flyback-Operation for Expanding the Regulation Range (2019)

LLC DC-DC converter can achieve high power efficiency because ZVS operation is possible in wide load range. However, when the load is light, and the input voltage is high, the operating frequency is becoming too high. Therefore, it is not suitable for applications with a frequency limit. Furthermore, it leads to high dv / dt, leading to lower reliability as power supply and EMI problem. Therefore, in this paper, it is proposed a control method that maintains regulation while suppressing the frequency increase at the time of light load of the secondary side synchronous rectification LLC DC-DC converter. Only the control method applied to the conventional circuit. Since the operation is similar to the flyback converter, it is called "flyback-operation" In the prototype experimental circuit of 48 V / 5 V - 200 W specification, the input voltage range can be increased by 23% when the load current is 0.75 A.
Prevention and treatment of experimental thrombosis in rabbits with rivaroxaban (BAY 597939) – an oral, direct factor Xa inhibitor (2007)

Current anticoagulant therapies for the prevention and treatment of thromboembolic disorders have many drawbacks: vitamin K antagonists interact with food and drugs and require frequent laboratory monitoring, and heparins require parenteral administration. Oral rivaroxaban (BAY 597939) is a new, highly selective and potent direct factor-Xa (FXa) inhibitor with a predictable pharmacodynamic and pharmacokinetic profile and could therefore be an attractive antithrombotic drug. It was the objective of this study to investigate the antithrombotic efficacy of oral rivaroxaban in two rabbit models of experimental venous thrombosis. In the venous stasis (prevention) model, animals were randomized to receive oral rivaroxaban 0.3, 1.0, 3.0 or 10.0 mg/kg or vehicle control. Thrombosis was induced by jugular vein stasis and injection of thromboplastin into the ear vein. In the venous thrombosis (treatment) model, intravenous (1.0 and 3.0 mg/kg) and oral (3.0 mg/kg) rivaroxaban was compared with intravenous nadroparin (40 U bolus and 20 U/h), fondaparinux (42 microg/kg) and vehicle control. Thrombus growth was assessed by measuring the accretion of radiolabelled fibrinogen into preformed clots in the jugular veins. Bleeding was assessed using an ear bleeding model. In the prevention model, rivaroxaban reduced thrombus formation dose-dependently (calculated ED(50) 1.3 mg/kg). In the treatment model, oral rivaroxaban (3.0 mg/kg) reduced thrombus growth to a similar extent to intravenous rivaroxaban (1.0 mg/kg), nadroparin and fondaparinux. Oral rivaroxaban did not prolong bleeding time. In conclusion, the orally available selective, direct FXa inhibitor rivaroxaban is effective in the prevention and treatment of venous thrombosis in two well-established models of experimental thrombosis.
Mechanically robust hydrophobized double network hydrogels and their fundamental salt transport properties (2021)

Abstract Water swollen polymer networks are attractive for applications ranging from tissue regeneration to water purification. For water purification, charged polymers provide excellent ion separation properties. However, many ion exchange membranes (IEMs) are brittle, necessitating the use of thick support materials that ultimately decrease throughput. To this end, novel double network hydrogels (DNHs) with variable water content are prepared and characterized in terms of mechanical and ion transport properties to evaluate their potential utility as tough membrane materials. The first network contains fixed anionic charges, while the other is comprised of a copolymer with varied ratios of hydrophobic ethyl acrylate (EA) and hydrophilic dimethyl acrylamide (DMA) repeat units. Characterization of freestanding DNH films reveals a reduction in water content from 88 to 53 wt% and a simultaneous increase in ultimate stress and strain by ~3.5× and ~4.5×, respectively, for 95%/5% EA/DMA, relative to 100% DMA. Fundamental salt transport properties relevant to water purification, including permeability, solubility, and diffusivity, are measured and systematically compared with conventional membrane materials to inform the development of DNHs for membrane applications. The ability to simultaneously reduce water content and increase mechanical integrity highlights the potential of DNHs as a synthetic platform for future membrane applications.
Supplementary Figure 2 from Angiopoietin-2 Functions as a Tie2 Agonist in Tumor Models, Where It Limits the Effects of VEGF Inhibition (2023)

&lt;p&gt;PDF file - 1.2MB, Histological analysis of the effect of REGN910 on the association of tumor blood vessels with pericytes&lt;/p&gt;
Efficient Use of Limited-Memory Accelerators for Linear Learning on Heterogeneous Systems (2017)

We propose a generic algorithmic building block to accelerate training of machine learning models on heterogeneous compute systems. Our scheme allows to efficiently employ compute accelerators such as GPUs and FPGAs for the training of large-scale machine learning models, when the training data exceeds their memory capacity. Also, it provides adaptivity to any system's memory hierarchy in terms of size and processing speed. Our technique is built upon novel theoretical insights regarding primal-dual coordinate methods, and uses duality gap information to dynamically decide which part of the data should be made available for fast processing. To illustrate the power of our approach we demonstrate its performance for training of generalized linear models on a large-scale dataset exceeding the memory size of a modern GPU, showing an order-of-magnitude speedup over existing approaches.
Synthesis and Structural Characterization of Chitosan Nanogels (2009)

Colloidal physical gels of pure chitosan were obtained via an ammonia-induced gelation in a reverse phase emulsion. The water weight fraction and the chitosan concentration in the water phase were optimized so as to yield nanogels with controlled particle size and size distribution. The spherical morphology of the nanogels was established by transmission electron microscopy with negative staining. Wide-angle X-ray scattering experiments showed that these gels were partially crystalline. The electrophoretic mobilities of the particles remained positive up to pH 7, above which the particles aggregated due to the charge neutralization. From the investigation on the colloidal stability of these nanogels in various conditions (pH, salt concentration, temperature), an electrosteric stabilization process of the particles was pointed out, related to the conformation of mobile chitosan chains at the gel-liquid interface. Therefore, the structure of the nanogels was deduced as being core-shell type, a gelified core of neutralized chitosan chains surrounded by partially protonated chains.
Raman spectroscopy: a diagnostic tool for detection of early malignant changes in the larynx (2000)

The incidence of laryngeal cancer has risen progressively over the last 25 years. Early diagnosis and treatment of premalignant lesions of the larynx is vital to prevent progression to invasive squamous cell carcinoma. In the larynx, it has long been recognized that histological evidence of maturation abnormality is associated with a higher risk of transformation to malignancy. Currently, it is extremely difficult if not impossible for the clinician to ascertain the level of abnormality present without removing a biopsy sample and sending it for histopathological analysis. Inherent risks with this technique include damage to vocal chords and loss of speech quality as well as possible selection of unrepresentative biopsy samples. Raman spectroscopy, incorporated into an endoscopic system, has the potential to provide a real-time, non-invasive diagnostic technique able to detect biochemical changes that accompany abnormal pathology. Likely outcomes would be improved biopsy targeting and patient management by providing immediate result of tissue pathology. This paper demonstrates the capacity of near IR Raman spectroscopy combine with statistical data analysis techniques to discriminate between normal, dysplastic and cancerous laryngeal tissue.
Anomalous Thermoelectric Transport Phenomena from First‐Principles Computations of Interband Electron–Phonon Scattering (2022)

Abstract The Seebeck coefficient and electrical conductivity are two central quantities to be optimized simultaneously in designing thermoelectric materials, and they are determined by the dynamics of carrier scattering. Here a new regime is uncovered where the presence of multiple electron bands with different effective masses, crossing near the Fermi level, leads to strong energy‐dependent carrier lifetimes due to intrinsic electron–phonon scattering. In this anomalous regime, electrical conductivity decreases with carrier concentration, Seebeck coefficient reverses sign even at high doping, and power factor exhibits an unusual second peak. The origin and magnitude of this effect is explained using a general simplified model as well as first‐principles Boltzmann transport calculations in recently discovered half‐Heusler alloys. General design rules for using this paradigm to engineer enhanced performance in thermoelectric materials are identified.
Biclustering ARTMAP collaborative filtering recommender system (2016)

Collaborative filtering provides recommendations based on the behavior of each user combined with behavior of users with similar interests. Recommender systems are becoming widespread, helping people choose movies, books, and things to buy. In this study, we examine the use of Biclustering ARTMAP to build a collaborative filtering recommendation system. We introduce a novel modification to how the Biclustering ARTMAP algorithm computes the item-cluster similarity, and a way to adapt it for the prediction of user ratings. We apply the algorithm to the MovieLens 100k dataset, and find that it achieves promising performance compared to other collaborative filtering techniques.
Additive for Low-Temperature Operation of Li-(CF)n Cells (2009)

Some progress has been reported in continuing research on the use of anion-receptor compounds as electrolyte additives to increase the sustainable rates of discharge and, hence, the discharge capacities, of lithium-poly(carbon monofluoride) [Li-(CF)n, where n >1] primary electrochemical power cells. Some results of this research at a prior stage were summarized in Increasing Discharge Capacities of Li(CF)n Cells (NPO-42346), NASA Tech Briefs, Vol. 32, No. 2 (February 2008), page 37. A major difference between the present and previously reported results is that now there is some additional focus on improving performance at temperatures from ambient down to as low as 40 C. To recapitulate from the cited prior article: During the discharge of a Li-(CF)n cell, one of the electrochemical reactions causes LiF to precipitate at the cathode. LiF is almost completely insoluble in most non-aqueous solvents, including those used in the electrolyte solutions of Li- (CF)n cells. LiF is electrochemically inactive and can block the desired transport of electrons at the cathode, and, hence, the precipitation of LiF can form an ever-thickening film on the cathode that limits the rate of discharge. An anion-receptor electrolyte additive helps to increase the discharge capacity in two ways: It renders LiF somewhat soluble in the non-aqueous electrolyte solution, thereby delaying precipitation until a high concentration of LiF in solution has been reached. When precipitation occurs, it promotes the formation of large LiF grains that do not conformally coat the cathode. The net effect is to reduce the blockage caused by precipitation of LiF, thereby maintaining a greater degree of access of electrolyte to the cathode and greater electronic conductivity.
Atmospheric atomic mercury monitoring using differential absorption lidar techniques (1989)

Three-dimensional mapping of atmospheric atomic mercury has been performed with lidar techniques, to our knowledge, for the first time. Industrial pollution monitoring, as well as measurements of background concentrations, is reported. High-efficiency frequency doubling of narrowband pulsed dye laser radiation was employed to generate intense radiation at the mercury UV resonance line. Field measurements were supplemented with extensive laboratory investigations of absorption cross sections and interfering lines of molecular oxygen.
ALimulusAntilipopolysaccharide Factor-Derived Peptide Exhibits a New Immunological Activity with Potential Applicability in Infectious Diseases (2000)

Previous studies have shown that cyclic peptides corresponding to residues 35 to 52 of the Limulus antilipopolysaccharide (anti-LPS) factor (LALF) bind and neutralize LPS-mediated in vitro and in vivo activities. Therapeutic approaches based on agents which bind and neutralize LPS activities are particularly attractive because these substances directly block the primary stimulus for the entire proinflammatory cytokine cascade. Here we describe new activities of the LALF(31-52) peptide, other than its LPS binding ability. Surprisingly, supernatants from human mononuclear cells stimulated with the LALF peptide are able to induce in vitro antiviral effects on the Hep-2 cell line mediated by gamma interferon (IFN-gamma) and IFN-alpha. Analysis of the effect of LALF(31-52) on tumor necrosis factor (TNF) and nitric oxide (NO) production by LPS-stimulated peritoneal macrophages revealed that a pretreatment with the peptide decreased LPS-induced TNF production but did not affect NO generation. This indicates that the LALF peptide modifies the LPS-induced response. In a model in mice with peritoneal fulminating sepsis, LALF(31-52) protected the mice when administered prophylactically, and this effect is related to reduced systemic TNF-alpha levels. This study demonstrates, for the first time, the anti-inflammatory properties of the LALF-derived peptide. These properties widen the spectrum of the therapeutic potential for this LALF-derived peptide and the molecules derived from it. These agents may be useful in the prophylaxis and therapy of viral and bacterial infectious diseases, as well as for septic shock.
Green (2010)

Energy-efficient computing is important in several systems ranging from embedded devices to large scale data centers. Several application domains offer the opportunity to tradeoff quality of service/solution (QoS) for improvements in performance and reduction in energy consumption. Programmers sometimes take advantage of such opportunities, albeit in an ad-hoc manner and often without providing any QoS guarantees.