gebhart/patrepeval huggingface dataset:
Recent advances in recombinant protein-based malaria vaccines (2015)

Plasmodium parasites are the causative agent of human malaria, and the development of a highly effective vaccine against infection, disease and transmission remains a key priority. It is widely established that multiple stages of the parasite's complex lifecycle within the human host and mosquito vector are susceptible to vaccine-induced antibodies. The mainstay approach to antibody induction by subunit vaccination has been the delivery of protein antigen formulated in adjuvant. Extensive efforts have been made in this endeavor with respect to malaria vaccine development, especially with regard to target antigen discovery, protein expression platforms, adjuvant testing, and development of soluble and virus-like particle (VLP) delivery platforms. The breadth of approaches to protein-based vaccines is continuing to expand as innovative new concepts in next-generation subunit design are explored, with the prospects for the development of a highly effective multi-component/multi-stage/multi-antigen formulation seeming ever more likely. This review will focus on recent progress in protein vaccine design, development and/or clinical testing for a number of leading malaria antigens from the sporozoite-, merozoite- and sexual-stages of the parasite's lifecycle-including PfCelTOS, PfMSP1, PfAMA1, PfRH5, PfSERA5, PfGLURP, PfMSP3, Pfs48/45 and Pfs25. Future prospects and challenges for the development, production, human delivery and assessment of protein-based malaria vaccines are discussed.
An Integrated High-Density Power Management Solution for Portable Applications Based on a Multioutput Switched-Capacitor Circuit (2015)

This paper introduces a novel power management architecture (PMA) and its on-chip implementation, designed for battery-powered portable applications. Compared to the conventional two-stage PMA, consisting of a front-end inductive converter followed by a set of point-of-load buck converters, the presented PMA has drastically improved power density. The new architecture, named multioutput switched-capacitor convertor-differential-input buck (MSC-DB) convertor, is based on a novel hybrid converter topology that combines a fixed ratio MSC and a set of DB converters, to achieve low volume and high power processing efficiency. The front-end switched-capacitor stage has a higher power density than the conventionally used inductive converters. The downstream DB converters enable tight output voltage regulation, and allow for up to four times reduction of output filter inductors without the need for increasing switching frequency, hence limiting switching losses and improving the efficiency of the system. Furthermore, the new PMA is able to balance the state-of-charge of the input battery cells, a feature not existing in conventional systems. The PMA architecture is implemented both as a discrete prototype and as an application-specific integrated circuit (IC) module. The on-chip implemented architecture is fabricated in a standard 0.13-μm CMOS process and operates at 9.3-MHz switching frequency. Experimental comparisons with a conventional two-cell battery input architecture, providing 15 W of total power in three different voltage outputs, demonstrate up to two times reduction in the inductances of the downstream converter stages and more than two times reduction in losses, equivalent to the improvement of the power processing efficiency of a 12%. Moreover, the fabricated IC module is copackaged with low-profile thin-film inductors to demonstrate the effectiveness of the introduced architecture in reducing the volume of PMAs for portable applications.
Use of Coanion Type and Concentration in Macrocycle-Facilitated Metal Cation Separations with Emulsion Liquid Membranes (1987)

Co-anion type and concentration are examined as parameters that can be varied to achieve various metal cation separations in macrocycle-facilitated emulsion liquid membranes. Membrane systems where the metal is present in the source phase as a complex anion or as a neutral complex (cation-anion(s)) are discussed. The experimental separations of Cd(II) from Zn(II) and/or Hg(II), Au(I) from Ag(I), and Au(III) from Pd(II) or Ag(I) are given to illustrate separation design using these membrane systems. The separations are discussed in terms of free energies of hydration, distribution coefficients, and equilibrium constants for the various interactions that occur.
Bidirectional amplification with linear optical amplifier in WDM-PON (2006)

To increase the system margin and service coverage in WDM-PON, bidirectional amplification with linear optical amplifier is demonstrated. We measured the sensitivity enhancement of 12.8 dB for downstream and 11.4 dB for upstream channel.
Films from spruce galactogluccomannan blended with poly(vinyl alcohol), corn arabonoxylan, and konjac glucomannan (2008)

The improvement of mechanical properties of spruce galactogluco-mannan (GGM)-based films was sought by blending GGM with each of poly(vinyl alcohol) (PVOH), corn arabinoxylan (cAX), and konjac glucomannan (KGM). The blend ratios were 3:1, 1:1, and 1:3 (w/w), and in addition films were made from each of the polymers alone. Glycerol was used as plasticizer. Adding other polymers increased the elongation at break of GGM blend films. The tensile strength of films increased with increasing amount of PVOH and KGM, but the effect of cAX was the opposite. Dynamic mechanical analysis showed two separate loss modulus peaks for blends of GGM and PVOH, but a single peak for all other films. Optical and scanning electron microscopy confirmed good miscibility of GGM with cAX and KGM. In contrast, films blended from GGM and PVOH showed phase separation when examined by microscopy.
Data from Genomic Analysis of Head and Neck Squamous Cell Carcinoma Cell Lines and Human Tumors: A Rational Approach to Preclinical Model Selection (2023)

&lt;div&gt;Abstract&lt;p&gt;Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of cancer worldwide. The increasing amount of genomic information on human tumors and cell lines provides more biologic data to design preclinical studies. We and others previously reported whole-exome sequencing data of 106 HNSCC primary tumors. In 2012, high-throughput genomic data and pharmacologic profiling of anticancer drugs of hundreds of cancer cell lines were reported. Here, we compared the genomic data of 39 HNSCC cell lines with the genomic findings in 106 HNSCC tumors. Amplification of eight genes (&lt;i&gt;PIK3CA&lt;/i&gt;, &lt;i&gt;EGFR&lt;/i&gt;, &lt;i&gt;CCND2&lt;/i&gt;, &lt;i&gt;KDM5A&lt;/i&gt;, &lt;i&gt;ERBB2&lt;/i&gt;, &lt;i&gt;PMS1&lt;/i&gt;, &lt;i&gt;FGFR1&lt;/i&gt;, and &lt;i&gt;WHSCIL1&lt;/i&gt;) and deletion of five genes (&lt;i&gt;CDKN2A&lt;/i&gt;, &lt;i&gt;SMAD4&lt;/i&gt;, &lt;i&gt;NOTCH2&lt;/i&gt;, &lt;i&gt;NRAS&lt;/i&gt;, and &lt;i&gt;TRIM33&lt;/i&gt;) were found in both HNSCC cell lines and tumors. Seventeen genes were only mutated in HNSCC cell lines (&gt;10%), suggesting that these mutations may arise through immortalization in tissue culture. Conversely, 11 genes were only mutated in &gt;10% of human HNSCC tumors. Several mutant genes in the EGF receptor (EGFR) pathway are shared both in cell lines and in tumors. Pharmacologic profiling of eight anticancer agents in six HNSCC cell lines suggested that &lt;i&gt;PIK3CA&lt;/i&gt; mutation may serve as a predictive biomarker for the drugs targeting the EGFR/PI3K pathway. These findings suggest that a correlation of gene mutations between HNSCC cell lines and human tumors may be used to guide the selection of preclinical models for translational research.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Implications:&lt;/b&gt; These findings suggest that a correlation of gene mutations between HNSCC cell lines and human tumors may be used to guide the selection of preclinical models for translational research.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Visual Overview:&lt;/b&gt; &lt;a href="http://mcr.aacrjournals.org/content/12/4/571/F1.large.jpg" target="_blank"&gt;http://mcr.aacrjournals.org/content/12/4/571/F1.large.jpg&lt;/a&gt;.&lt;/p&gt;&lt;p&gt;&lt;i&gt;Mol Cancer Res; 12(4); 571–82. ©2014 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Glycosylation and Deamidation of Rice Endosperm Protein for Improved Solubility and Emulsifying Properties (2007)

ABSTRACT Rice endosperm protein was prepared by alkali‐extraction method and subsequently modified by controlled glycosylation (RP Glu , RP XG ), deamidation (RP DA ), and enzymatic hydrolysis by alcalase (RP Alc ) methods. The RP Glu and RP XG were prepared by Maillard type glycosylation with D‐glucose and xanthan gum, respectively. The glycosylation improved the emulsion activity (0.721) and stability (26.8 min) of the protein but did not show a substantial improvement in solubility (39.7%). The rice protein modified by controlled alkali‐deamidation (RP DA ) showed highest solubility (68%), emulsion activity (0.776), and emulsion stability (24 min) among the three protein modification methods evaluated in this study. The alcalase treatment to 1.8% DH (RP Alc ) slightly improved solubility (33%), emulsion activity (0.468), and emulsion stability (17.5 min) compared with unmodified rice protein (RP), which had 18% solubility, 0.266 emulsion activity, and 14.7 min emulsion stability. The glycosylation and deamidation methods were more effective than the controlled enzymatic hydrolysis by alcalase in improving solubility and emulsifying properties of rice endosperm protein. Glycosylated and deamidated rice endosperm proteins can find application in enhancing emulsifying properties in suitable products.
Aziala-net (2009)

Aziala-net is a flexible and scalable experimental testbed for wireless multi-hop networks based on simple off-the-shelf hardware that is able to adapt to various research purposes. It is composed of more than 50 Asus wireless routers that have been adapted to either work as fixed base station or as mobile nodes. After describing the technical details of Aziala-net, we illustrate the potential of the testbed by showing two samples of works that are currently under study in the testbed. The first example focus on the use of the IEEE 802.11 MAC layer protocol for multi-hop networks and the stability problem that it faces in the case of wireless mesh networks. The second example focus on epidemic forwarding protocols and their performance in a real testbed deployment.
Embryo viability and metabolism: obeying the quiet rules (2007)

The challenge is to identify the range of values for a given marker within which an embryo has a high chance of giving rise to healthy offspring. We also speculate on the ways in which such a metabolic profile might be encouraged and the implications for weight loss in obese women prior to conception.
Iron Chalcogenide Photovoltaic Absorbers (2011)

An integrated computational and experimental study of FeS2 pyrite reveals that phase coexistence is an important factor limiting performance as a thin-film solar absorber. This phase coexistence is suppressed with the ternary materials Fe2SiS4 and Fe2GeS4, which also exhibit higher band gaps than FeS2. Thus, the ternaries provide a new entry point for development of thin-film absorbers and high-efficiency photovoltaics.
Molded, High Surface Area Polymer Electrolyte Membranes from Cured Liquid Precursors (2006)

Polymer electrolyte membranes (PEMs) for fuel cells have been synthesized from easily processable, 100% curable, low molecular weight reactive liquid precursors that are photochemically cured into highly proton conductive solid membranes. The liquid precursors were directly cured into membranes of desired dimensions without the need for further processing steps such as melt extrusion or solvent casting. By employing chemical cross-linking, high proton conductivities can be achieved through the incorporation of significant levels of acidic groups without rendering the material water-soluble, which plagues commonly used non-cross-linked polymers. Fabrication of membrane electrode assemblies (MEAs) from these PEMs resulted in fuel cells that outperformed those based on commercial materials. Moreover, these liquid precursors enabled the formation of three-dimensional, patterned PEMs with high fidelity, micron-scale features by using soft lithographic/micromolding techniques. The patterned membranes provided a larger interfacial area between the membrane and catalyst layer than standard flat PEMs. MEAs composed of the patterned membranes demonstrated higher power densities over that of flat ones without an increase in the macroscopic area of the fuel cells. This can potentially miniaturize fuel cells and promote their application in portable devices.
Hierarchical Assembly and Sensing Activity of Patterned Graphene‐Hamilton Receptor Nanostructures (2022)

Abstract Structuring distinct building blocks on graphene can open enormous opportunities for constructing well‐ordered hierarchical 2D architectures and multifunctional devices useful in numerous practical applications. However, such highly integrated graphene nanostructures featuring functional building blocks remain elusive and the reported graphene 2D‐patterning examples are up to now limited to small addends without easily accessible anchor points. Herein, the first realization of patterning extensible building blocks on graphene is presented, in which Hamilton receptor units as characteristic motifs are efficiently patterned onto monolayer graphene by combining the mask‐assisted patterning technique and the reductive K/Na activation/functionalization of graphene. This further enables, for the first time, a hierarchical assembly of nanoparticles on graphene, by taking advantage of the hydrogen‐bond mediated binding between the Hamilton receptors structured on graphene and cyanurate moieties bound on TiO 2 nanoparticles. The grafting of nanoparticles on graphene is fully reversible upon breakage of the supramolecular interaction within the Hamilton receptor/cyanurate pair by acetone. The structure and stability of Hamilton receptors on graphene and their interaction with cyanurate are confirmed by theoretical calculations. Moreover, the integration of this graphene nanostructure with Hamilton receptors into field‐effect transistors allows for an ultrasensitive and quantitative detection of cyanurate/barbiturate moiety down to the 1 × 10 −6 m level.
Optimizing the Amplifier Bandwidth for Pulse Reception (2021)

&lt;p&gt;Detecting and recognizing pulses is a critical task, in fields as widely separated as telecommunications, lidar, and target illumination. In all cases, the signal-to-noise ratio (SNR) is a key parameter that can be used to determine both the potential rate of errors and the probability of correct detection. In this paper the relationship among pulse width, amplifier bandwidth, and SNR is determined through modeling four approximations to pulse shapes and four amplifier lowpass filter configurations. The analysis determined that, given a specific filter and pulse shape, the bandwidth that maximizes SNR is a constant divided by the pulse width. For example, if the pulse has a Gaussian shape and the amplifier incorporates a second-order Chebyshev lowpass filter, this constant is 0.3389. Applying this, if the pulse width is 20 ns the maximum SNR comes for a filter bandwidth of 16.95 MHz, while if the pulse width is 50 µs the SNR is maximized at a 6.778-kHz bandwidth. Passing the signal through a filter also distorts the signal shape; the temporal shift and pulse lengthening are also determined. The calculated values are offered as inputs to a potential trade space that includes SNR, pulse distortion by the filter, and cost.&lt;/p&gt;
Abstract 1825: SAR443216, a novel trispecific T cell engager with potent T cell-dependent cytotoxicity for HER2-low tumors (2021)

Abstract Current HER2-targeted therapies have markedly improved the outcome of cancer patients with HER2 overexpressing tumors. However, these patients may eventually relapse or develop treatment resistance. In addition, HER2-low patients that are not eligible for treatment constitute a significant portion of the breast cancer patients. To address these unmet needs, we have developed a novel HER2-targeting T cell engager, SAR443216. This is a trispecific antibody with binding sites for HER2, CD3 and CD28, and containing a mutated IgG4-Fc which lacks effector functions. CD28 binding contributes to T cell activation, including activation of IL-2 and NFκB pathways, as well as induction of anti-apoptotic protein, Bcl-xL. In the presence of HER2-positive cancer cells, SAR443216 is able to activate primary human CD4 and CD8 T cells, resulting in T cell proliferation and secretion of cytokines and granzyme B. Moreover, it has potent in vitro T cell-dependent cellular cytotoxicity (TDCC) against a panel of HER2-expressing cancer cell lines, including those that are HER2-low. The potency of in vitro TDCC is largely correlated with HER2 surface expression in the target cells. Finally, in a HER2-low breast cancer xenograft model, SAR443216 also exhibited significant anti-tumor activity in immuno-deficient NSG mice reconstituted with primary human T cells. Thus, SAR443216 represents a promising new drug for cancer patients with HER2-expressing tumors, including those who are currently ineligible for stand-of-care therapy. Citation Format: Wenwen Sha, Sri Vadde, Zhili Song, Edward Seung, Zhen Xing, Liqing Chen, Virna Cortez-Retamozo, Sukhvinder Sidhu, Dinesh Bangari, Lan Wu, Ronnie Wei, Zhi-yong Yang, Gary Nabel, Vasiliki Pelekanou, Michele Sanicola-Nadel, Serena Masciari, Dmitri Wiederschain, Lily Pao. SAR443216, a novel trispecific T cell engager with potent T cell-dependent cytotoxicity for HER2-low tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 1825.
Effect of Bone Morphogenetic Protein-2-Expressing Muscle-Derived Cells on Healing of Critical-Sized Bone Defects in Mice (2001)

Ex vivo gene therapy with muscle-derived cells that have been genetically engineered to express BMP-2 may be used to treat nonhealing bone defects. In addition, muscle-derived cells appear to include stem cells, which are easily obtained with muscle biopsy and could be used in gene therapy to deliver BMP-2.
Momentum exchanges in coupled ocean-wave modeling system (2018)

COAMPS <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">©</sup> is a fully coupled, data-assimilative, ocean-atmosphere-wave modeling system. The system consists of the meteorological model COAMPS, the Navy Coastal Ocean Model (NCOM), and two interchangeable wave models SWAN and WAVEWATCH III. Coupling of the models is accomplished via the Earth System Modeling Framework (ESMF) where surface fluxes of momentum, heat, and moisture, sea level pressure, sea surface heights, currents, Stokes drift currents, and wave forces are exchanged across the air-sea-wave interface. Transfer of energy from waves to the ocean currents is accounted for via the radiation stress gradients or through the dissipation source terms of the wave model. In this paper, the coupling methods and the effects of the momentum flux transfer between the wave model and the ocean model in a two-way coupled mode are presented. We focus on the dynamics of the coupled wave-ocean system for the US East Coast. The results show the dissipation method improves the vertical profiles of temperature and salinity, especially near the surface of the ocean.
BIOREFINERY: Nanofibrillated cellulose for enhancement of strength in high-density paper structures (2013)

Article BIOREFINERY: Nanofibrillated cellulose for enhancement of strength in high-density paper structures was published on May 1, 2013 in the journal Nordic Pulp & Paper Research Journal (volume 28, issue 2).
Practical considerations in the design of multiphase pick-ups for contactless power transfer systems (2009)

Contactless power transfer systems are receiving newfound attention, although current commercial systems can only tolerate limited movement of the receiver relative to the track (transmitter). A new multi-phase (Quadrature) pick-up has previously been presented to extend the allowable movement. This paper presents a high power prototype of the quadrature pick-up based on a commercial pick-up design for AGV systems. Practical aspects of the design are covered, such as producing a consistent power output with lateral movement, and maintaining vertical clearance between the pick-up and the track.
Urachal Duct Carcinoma Complicating Pregnancy (2013)

Urologic malignancies are rare but should be considered in the differential diagnosis for any woman presenting with pain and an abdominal mass in pregnancy. A multidisciplinary approach optimizes outcomes.
Image Quality Metrics (2000)

Advances in image synthesis techniques allow us to simulate the distribution of light energy in a scene with great precision. Unfortunately, this does not ensure that the displayed image will have a high fidelity visual appearance. Reasons for this include the limited dynamic range of displays, any residual shortcomings of the rendering process, and the extent to which human vision encodes such departures from perfect physical realism. Image quality metrics are paramount to provide quantitative data on the fidelity of rendered images. This course addresses techniques to compare real and synthetic images, identify important visual system characteristics and help reduce rendering times significantly. Case studies involving both static and dynamic images are considered. Their different image quality metric requirements are compared and contrasted.
Differential response to adjuvant chemotherapy based on Lauren subtype affects clinical outcome of gastric cancer: A cohort study and meta-analysis. (2018)

4048 Background: There remains significant questions on the efficacy of adjuvant chemotherapy for Lauren subtype of gastric cancer (GC). We aimed to clarify whether intestinal gastric cancer (IGC) patients have improved response to current chemotherapy regimens resulting in better survival when compared to diffuse gastric cancer (DGC) patients after adjuvant chemotherapy. Methods: A dataset comprising 8599 GC patients from 23 publications, combined with our cohort, was included in the meta-analysis. Results: In our cohort, the overall survival of IGC receiving adjuvant chemotherapy (chemoIGC) (median OS 5·01 years, IQR 2·63-6·71) was significantly higher than that of DGC receiving adjuvant chemotherapy (chemoDGC) (median OS 1·33 years, IQR 0·78-3·33, P = 0·0001). The HR for OS of the chemoIGC compared to chemoDGC was 0·27 (95% CI 0·13-0·52). There was a significant difference of OS between chemoIGC and IGC (HR 0·32, 95% CI 0·16-0·64, P = 0·001) whereas no difference between chemoDGC and DGC (HR 1·26, 95% CI 0·69-2·29, P = 0·46), indicating that IGC patients benefit more from adjuvant chemotherapy than DGC patients. After adjusting for age, gender and stage, adjuvant chemotherapy was an independent risk factor for survival in Lauren subtype of GC (HR for OS of the chemoIGC / chemoDGC 0·33, 95%CI 0·17-0·65, P < 0·001). Importantly, the meta-analysis results of 24 studies consisting of 4050 chemoIGC and 4549 chemoDGC patients indicated that chemoIGC showed significantly improved OS (HR 0·78; 95% CI, 0·72-0·84; P < 0·0001) and PFS (HR 0·80; 95% CI, 0·64-0·99; P = 0·04) comparing to similarly treated patients of chemoDGC. Conclusions: Our results support consideration of a change of clinical practice in the decisions related to administration of adjuvant chemotherapy for DGC patients. We found, DGC patients may not attain the same survival or efficacy as IGC from adjuvant chemotherapy. The Lauren subtype may be useful in treatment decisions in GC patients. We contend that Lauren classification and molecular subgroup should be used to stratify treatment regimens to GC patients, with particular relevance to diffuse subtype which is more difficult to treat with current regimens.