gebhart/patrepeval huggingface dataset:
Possibility of Antiseptic Formula Employing Pionin Combination with 1,2-Pentanediol in the Cosmetic Field (2003)

最も繁用されている化粧品防腐剤であるパラベンは, 近年次々とその有害性が報告されている。そこでわれわれはピオニンと1,2-pentanediolをパラベンのように化粧品防腐剤として使用できるかを細菌学的見地から評価した。市販化粧品にピオニンを添加して抗菌活性を検討し, ピオニンはさまざまな化粧品製剤において強力な抗菌活性を発揮することを確認した。また, ローション製剤においてピオニンと1,2-pentanediolの併用添加は, パラベン添加よりも抗菌活性が上回ることを見出した。さらにパラベン無添加で行ったピオニンと1,2-pentanediol含有クリーム製剤中での抗菌試験では, 局方における防腐剤の条件を十分満たすことが明らかとなった。この製剤を健常ヒト皮膚へ7日間連続塗布し検討したところ, 皮膚常在菌数の日常変動に対して有意な影響を及ぼさなかった。これらよりピオニンと1,2-pentanediolの併用は, 化粧品製剤の新しい防腐処方となることが示唆された。
Ectoine disperses keratin and alters hydration kinetics in stratum corneum (2021)

Moisturizing compounds are commonly applied topically to human stratum corneum (SC). Many types of molecular species are employed, most commonly including humectants and occlusives. We find new evidence of keratin dispersion caused by the moisturizing compound ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), and provide the first characterization of its impacts on the hydration kinetics and biomechanics of SC. A second compound, 2-(2-hydroxyethoxy)ethylguanidine succinate (HEG) was investigated for comparison. A suite of biomechanical and biochemical assays including FTIR, drying stress, and cellular cohesion were used. Studies were conducted on normal, lipid-extracted, and lipid plus natural moisturizing factor extracted SC. Ectoine was found to improve the dispersity and hydration of keratin bundles in corneocytes. It also decreased rates of stress development in lipid extracted SC when exposed to a dry environment by ∼30% while improving stress reduction during rehydration by ∼20%. Peak stresses were increased in harsh drying environments of <5% RH, but SC swelling measurements suggest that water retention was improved in ambient conditions. Further, changes up to ∼4 J/m<sup>2</sup> were seen in cohesion after ectoine treatments, suggesting corneodesmosome interactions. HEG was tested and found to disperse keratin without impacting corneodesmosomes. These results indicate that keratin dispersants produce beneficial effects on SC hydration kinetics, ultimately resulting in higher SC hydration under ambient conditions.
Hepatitis C Virus Heteroduplex Tracking Assay for Genotype Determination Reveals Diverging Genotype 2 Isolates in Italian Hemodialysis Patients (1998)

A heteroduplex tracking assay (HTA) was developed for genetic analyses of the hepatitis C virus (HCV) using single-stranded probes from the core (C)/E1 region. Nucleotide sequencing of reverse transcriptase (RT)-PCR products from 15 Italian dialysis patients confirmed the specificity and accuracy of the HTA genotyping method, which identified 5 of 15 (33.3%) 1b, 7 of 15 (46.7%) 3a, and 3 of 15 (20%) type 2 infections. The genotypes of an additional 12 HCV antibody-positive blood donors from different geographical locations were also in agreement with the genotypes determined by the Inno-LiPA HCV II kit (Innogenetics) and/or restriction fragment length polymorphism (RFLP). Isolates which had between 35 to 40% nucleotide divergence from control subtype 1a, 1b, 2a, 2b, or 3a standards could be typed. Surprisingly, HTA detected one 1b-2 coinfection which was missed by DNA sequencing. Three samples that were designated non-2a or 2b type 2 by HTA were found to be type 2a by both RFLP and direct nucleotide sequencing of the 5' untranslated region. The genetic distance between patient type 2 and control 2a, 2b, and 2c isolates indicated that a new subtype was present in the population being studied. Serotyping (RIBA serotyping strip immunoblot assay kit) of 23 dialysis patients showed that the genotype could be determined in 6 of 8 (75%) C/E1 RT-PCR-negative and 15 of 23 (65.2%) RT-PCR-positive samples, indicating that the two tests complement each other.
CITY INFEED WITH HVDC LIGHT® AND EXTRUDED CABLES (2006)

Urban electrical power systems with steep demand increase need easily located solutions with short lead time from decision to transmission. While AC cable solutions can offer sufficient power ratings, the problems of load controllability and short circuit power increase with every added circuit. These problems may be countered with Voltage Source Converter (VSC) based technology using DC-cables for transmission, such as HVDC Light®. This technology offers up to 500 MW per station with small footprint, ideal for infeed to city centers. Fast implementation is possible thanks to modular pre-assembled design and extruded polymer underground cables. System benefits from the VSC technology, such as independent full active and reactive power control and no added short circuit power makes it easy to apply in a heavily loaded grid. From an environmental point of view, the dc-cable technology gives virtually no alternating magnetic field and no risk for oil leakage. Higher transmission capacity is possible through polymer DC-cables as compared to equivalent AC-cables. A number of different topologies are possible for single or multi-infeed, giving large freedom of design to adapt to each specific network situation. 1.
Feature analysis for quality assessment of reverberated speech (2009)

This paper analyzes the ability of several measurements to quantify the reverberation effect in speech signals. We consider an intrusive scheme, in which the clean and reverberated signals are available, allowing one to estimate the corresponding room impulse response (RIR) signal. An artificial neural network (ANN) is trained for all features and used in a regression approach to estimate the human perceptual evaluation in a mean opinion score (MOS) 1–5 scale. Dimensionality reduction approaches are applied to generate a simpler ANN regression, establishing the most representative features for the problem at hand. A correlation level of 85% with subjective test scores was achieved by reducing the input-vector dimension from 10 to 3, including only the features of reverberation time, room spectral variance, and direct-to-reverberant energy ratio.
GC-MS and oxygen-17 NMR tracer studies of triethylphosphine oxide formation from auranofin and water-17O in the presence of bovine serum albumin: an in vitro model for auranofin metabolism (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGC-MS and oxygen-17 NMR tracer studies of triethylphosphine oxide formation from auranofin and water-17O in the presence of bovine serum albumin: an in vitro model for auranofin metabolismAnvarhusein A. Isab, C. Frank Shaw III, and James LockeCite this: Inorg. Chem. 1988, 27, 19, 3406–3409Publication Date (Print):September 1, 1988Publication History Published online1 May 2002Published inissue 1 September 1988https://pubs.acs.org/doi/10.1021/ic00292a027https://doi.org/10.1021/ic00292a027research-articleACS PublicationsRequest reuse permissionsArticle Views87Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Legend from Tumor-Localized Costimulatory T-Cell Engagement by the 4-1BB/HER2 Bispecific Antibody-Anticalin Fusion PRS-343 (2023)

&lt;p&gt;Supplementary Legend&lt;/p&gt;
A Neutralizing Anti–Fibroblast Growth Factor 8 Monoclonal Antibody Shows Potent Antitumor Activity against Androgen-Dependent Mouse Mammary Tumors In vivo (2005)

KM1334 possesses strong blocking activity in vitro and antitumor activity in vivo and therefore may be an effective therapeutic candidate for the treatment of cancers that are dependent on FGF8b signaling for growth and survival.
Shared Neural Substrates Controlling Hand Movements in Human Motor Cortex (1995)

Voluntary hand movements in humans involve the primary motor cortex (M1). A functional magnetic resonance imaging method that measures relative cerebral blood flow was used to identify a distributed, overlapping pattern of hand movement representation within the posterior precentral gyrus, which contains M1. The observed pattern resembles those reported in nonhuman primates and differs from a somatotopically organized plan typically used to portray human motor cortex organization. Finger and wrist movements activated a wide expanse of the posterior precentral gyrus, and representations for different finger movements overlapped each other and the wrist representation. Multiple sites of activation occurred in the precentral gyrus for all movements. The overlapping representations may mediate motor and cognitive functions requiring coordinated neural processing for finger and wrist actions rather than discrete control implied by somatotopic maps.
Yaw Motion Stability of an Indonesian Ro-Ro Ferry in Adverse Weather Conditions (2020)

The yaw motion stability and course-keeping ability of ships are important factors with regard to collision danger, particularly for ships operating in narrow channels, crowded routes, or port areas. Yaw motion may become unstable due to external
High voltage lateral MOS thyristor cascode switch on SOI-safe operating area of SOI-Resurf devices (2002)

A high voltage lateral MOS thyristor cascode switch on SOI was proposed. It consists of a high voltage MOS thyristor, a low voltage MOSFET and a pn diode. Excellent on-state and switching characteristics were numerically and experimentally obtained. The safe operating area (SOA) of SOI-Resurf devices were discussed.
A new medium voltage PWM inverter topology for adjustable speed drives (2002)

In this paper a new PWM inverter topology suitable for medium voltage (2300/4160 V) adjustable speed drive (ASD) systems is proposed. The modular inverter topology is derived by combining three standard 3-phase inverter modules and a 0.33 pu output transformer. The output voltage is high quality, multistep PWM with low dv/dt. Further, the approach also guarantees balanced operation and 100% utilization of each 3-phase inverter module over the entire speed range. These features enable the proposed topology to be suitable for powering constant torque as well as variable torque type loads. Clean power utility interface of the proposed inverter system can be achieved via an 18-pulse input transformer. Analysis, simulation, and experimental results are shown to validate the concepts.
Microcavity-Mediated Spectrally Tunable Amplification of Absorption in Plasmonic Nanoantennas (2019)

Nanoantenna-microcavity hybrid systems offer unique platforms for the study and manipulation of light at the nanoscale, since their constituents have either low mode volume or long photon storage time. A nearby dielectric optical cavity can modify the photonic environment surrounding a plasmonic nanoantenna, presenting opportunities to sculpt its spectral response. However, matching the polar opposites for enhanced light-matter interactions remains challenging, as the antenna can be rendered transparent by the cavity through destructive Fano interferences. In this work, we tackle this issue by offering a new plasmonic-photonic interaction framework. By coupling to a photonic crystal guided resonance, a gold nanostar delivers 1 order of magnitude amplified absorption, and the ultrasharp Lorentzian-line-shaped hybrid resonance is continuously tunable over a broad spectral range by scanning of the incidence angle. Our intuitive coupled mode model reveals that a distinct optical pathway highlighting the cavity-mediated activation of nanoantennas is key for absorption enhancement. Moreover, we show that the line width of the enhancement can be widely tunable, and that the maximum power transferred to the antennas is attained under critical coupling. The cooperative hybrid system opens up new opportunities to boost a wealth of applications including ultrasensitive molecular spectroscopy, plasmonic hot carrier chemistry, thermoplasmonic, spontaneous emission enhancement, nanolasers, and many more.
Computer Assisted Mechanistic Evaluation of Organic Reactions. 23. Dissolving Metal Reductions with Lithium in Liquid Ammonia Including the Birch Reduction (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComputer Assisted Mechanistic Evaluation of Organic Reactions. 23. Dissolving Metal Reductions with Lithium in Liquid Ammonia Including the Birch ReductionShenna Sinclair and William L. JorgensenCite this: J. Org. Chem. 1994, 59, 4, 762–772Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://pubs.acs.org/doi/10.1021/jo00083a017https://doi.org/10.1021/jo00083a017research-articleACS PublicationsRequest reuse permissionsArticle Views441Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Snap-Top Nanocarriers (2010)

An approach to the design and fabrication of mechanized mesoporous silica nanoparticles is demonstrated at the proof of principle level. It relies on the reductive cleavage of disulfide bonds within an integrated nanosystem, wherein surface-bound rotaxanes incorporate disulfide bonds in their stalks, which are encircled by cucurbit[6]uril or alpha-cyclodextrin rings, until reductive chemistry is performed, resulting in the snapping of the stalks of the rotaxanes, leading to cargo release from the inside of the nanoparticles.
Niacin Attenuates Pulmonary Hypertension Through H-PGDS in Macrophages (2020)

Niacin treatment ameliorates the progression of PAH through the suppression of vascular remodeling by stimulating H-PGDS-derived PGD<sub>2</sub> release from macrophages.
Highlights of the ISSCC 2013 Processors and High Performance Digital Sessions (2014)

This special issue covers the ISSCC conference held in San Francisco, CA, USA, on February 17-21, 2013. The issue includes the topics from the low power and high performance digital, memory, and technology directions as well as imagers, medical and sensors. There are 27 papers in the issue.
Autoantigen can promote progression to a more aggressive TCL1 leukemia by selecting variants with enhanced B-cell receptor signaling (2013)

(Auto)antigen engagement by the B-cell receptor (BCR) and possibly the sites where this occurs influence the outcome of chronic lymphocytic leukemia (CLL). To test if selection for autoreactivity leads to increased aggressiveness and if this selection plays out equally in primary and secondary tissues, we used T-cell leukemia (TCL)1 cells reactive with the autoantigen phosphatidylcholine (PtC). After repeated transfers of splenic lymphocytes from a single mouse with oligoclonal PtC-reactive cells, outgrowth of cells expressing a single IGHV-D-J rearrangement and superior PtC-binding and disease virulence occurred. In secondary tissues, increased PtC-binding correlated with enhanced BCR signaling and cell proliferation, whereas reduced signaling and division of cells from the same clone was documented in cells residing in the bone marrow, blood, and peritoneum, even though cells from the last site had highest surface membrane IgM density. Gene-expression analyses revealed reciprocal changes of genes involved in BCR-, CD40-, and PI3K-signaling between splenic and peritoneal cells. Our results suggest autoantigen-stimulated BCR signaling in secondary tissues promotes selection, expansion, and disease progression by activating pro-oncogenic signaling pathways, and that--outside secondary lymphoid tissues--clonal evolution is retarded by diminished BCR-signaling. This transferrable, antigenic-specific murine B-cell clone (TCL1-192) provides a platform to study the types and sites of antigen-BCR interactions and genetic alterations that result and may have relevance to patients.
Supplementary Table 1 from Targeting the SUMO Pathway Primes All-<i>trans</i> Retinoic Acid–Induced Differentiation of Nonpromyelocytic Acute Myeloid Leukemias (2023)

&lt;p&gt;Supplementary Table 1: Characteristics of all patients used in Figure 7 or Supplementary Figure 4. D: diagnosis, R:relapse. For the molecular characteristics, only those routinely clinically tested are indicated.&lt;/p&gt;
Nuclear Pumping of a Neutral Carbon Laser (1978)

Nuclear pumped lasing on the neutral carbon line at 1.45 micron was achieved in mixtures of He-CO, He-N2-CO, He-CO2, and Ne-CO and Ne-CO2. A minimum thermal neutron flux of 2 x 10 to the 14th power sq cm-sec was sufficient for oscillation in the helium mixtures. The peak of the laser output was delayed up to 5.5 ms relative to the neutron pulse in He-CO2, He-N2-CO, Ne-CO, and Ne-CO2 mixtures while no delay was observed in He-CO mixtures. Lasing was obtained with helium pressures from 20 to 800 T, Ne pressures from 100 to 200 T, CO from 0.25 to 20 mT, N2 from 0.5 mT, and CO2 from 0.1 to 25 mT in the respective mixtures.
Posterior approach to the elbow for insertion of the internal joint stabilizer (2021)

Management of unstable injuries was revolutionized by the Internal Joint Stabilizer (IJS). When compared to long-term immobilization, transarticular pinning, and hinge external fixation, the IJS results in decreased complications and improved clinical outcomes. Historically, the IJS was applied via a lateral approach; however, this limited intraoperative visualization and, in some cases, resulted in increased operative times. This technical report describes a posterior approach, for IJS application. The posterior approach involves an 8- to 10-cm incision over the posterior elbow through the deep fascia before identifying the olecranon and lateral capitellum, then proceeding with IJS application through manufacturer instructions. The ulnar and radial nerves must be identified as they could be damaged in this approach. Using the posterior approach at our institution, we have noticed a possible decrease in operative times and an increase in intraoperative visualization of the elbow without a subsequent increase in complications.
Acoustic Well Stimulation - Theory and Applications (1998)

Abstract This paper is dedicated to possibilities of extending life of oil fields through the acoustic well stimulations (AWS) which allow to increase oil production without damage for the environment.
Giardia lamblia: haploid genome size determined by pulsed field gel electrophoresis is less than 12 Mb (1991)

Previous estimates of the size of the Giardia lamblia genome have ranged from 30 to 80 million base pairs (Mb), based on DNA renaturation kinetics. This is much larger than the sum of the sizes of the 4 to 5 chromosomal DNAs seen in typical pulsed field gel electrophoretic analyses. One possible explanation is that each visible chromosomal DNA consists of several unresolved DNA species. To examine this we have performed quantitative densitometry of ethidium stained chromosomal DNAs and Notl genomic digests. We have also examined the distribution of rDNA on Notl genomic fragments. All of our results suggests that the true genome size is 10.6 to 11.9 Mb. It is conceivable that the previous larger estimates may be distorted by impurities in the DNA preparations used.
An improved procedure to prepare 3-methyl-4-nitroalkylenethylisoxazoles and their reaction under catalytic enantioselective Michael addition with nitromethane (2014)

Herein, we describe a short synthesis of 3-methyl-4-nitro-5-alkylethenyl isoxazoles and their reactivity as Michael acceptors. The title compounds reacted with nitromethane under phase-transfer catalysis to provide highly enantioenriched adducts (up to 93% ee) which were then converted to the corresponding γ-nitroacids.
Distributed mobility management: A standards landscape (2013)

In this article, we introduce distributed mobility management (DMM) - a new architectural paradigm for evolving mobile IP networks. We discuss the technology trends that are driving a move toward DMM and what the relevant standards development organizations (IETF and 3GPP) are doing to address these new needs. We conclude with a discussion of how 3GPP's evolved packet core can evolve toward a DMM-based architecture.
Expression of fhit protein during mouse development (2000)

Fhit protein has a putative tumor suppressor function in several types of human and experimental cancers. To assess whether Fhit is involved in fetal development we have examined the distribution of Fhit protein in the 12- through 16-day postcoitum mouse fetus and in postnatal day 0 mouse pups by immunocytochemistry. High levels of Fhit protein were observed in the endodermal derivatives, namely, bronchi, trachea, esophagus, stomach, and intestine, in the 12- to 16-day postcoitum mouse fetus and in the postnatal day 0 pup. Other tissues showed a more restricted pattern of Fhit protein expression. These results suggest that Fhit may play a role in the development of specific tissues during mouse development. Anat Rec 260:208–211, 2000. © 2000 Wiley-Liss, Inc.
Data from <i>N-</i>Methyl-d-Aspartate Receptor Type 2B Is Epigenetically Inactivated and Exhibits Tumor-Suppressive Activity in Human Esophageal Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;Promoter hypermethylation accompanied by gene silencing is a common feature of human cancers. We identified previously several new tumor suppressor genes based on pharmacologic unmasking of the promoter region and detection of reexpression on microarray analysis. In this study, we modified the selection of candidates from our previous microarray data by excluding genes that showed basal expression in cancer cell lines. With the new method, we found novel methylated genes with 90% accuracy. Among these 33 novel methylated genes that we identified in esophageal squamous cell carcinoma (ESCC) cell lines, &lt;i&gt;N&lt;/i&gt;-methyl-d-aspartate receptor type 2B (&lt;i&gt;NMDAR2B&lt;/i&gt;) was of particular interest. &lt;i&gt;NMDAR2B&lt;/i&gt; was methylated in 95% of primary human ESCC tissue specimens and 12 ESCC cell lines by sequence analysis. &lt;i&gt;NMDAR2B&lt;/i&gt; expression was silenced in all 12 ESCC cell lines and was reactivated by the demethylating agent 5-aza-2′-deoxycytidine. Moreover, reintroduction of the gene was accompanied by marked Ca&lt;sup&gt;2+&lt;/sup&gt;-independent apoptosis in ESCC cell lines, suggesting that &lt;i&gt;NMDAR2B&lt;/i&gt; can suppress tumor growth. Thus, &lt;i&gt;NMDAR2B&lt;/i&gt; promoter methylation is common in ESCC, abrogating gene transcription and leading to cellular resistance to apoptosis. (Cancer Res 2006; 66(7): 3409-18)&lt;/p&gt;&lt;/div&gt;