gebhart/patrepeval huggingface dataset:
Targeted Minimum Loss Based Estimation of a Causal Effect on an Outcome with Known Conditional Bounds (2012)

This paper presents a targeted minimum loss based estimator (TMLE) that incorporates known conditional bounds on a continuous outcome. Subject matter knowledge regarding the bounds of a continuous outcome within strata defined by a subset of covariates, X, translates into statistical knowledge that constrains the model space of the true joint distribution of the data. In settings where there is low Fisher Information in the data for estimating the desired parameter, as is common when X is high dimensional relative to sample size, incorporating this domain knowledge can improve the fit of the targeted outcome regression, thereby improving bias and variance of the parameter estimate. We show that TMLE, a substitution estimator defined as a mapping from a density to a (possibly d-dimensional) real number, readily incorporates this global knowledge, resulting in improved finite sample performance.
1995 IEEE 16. symposium on fusion engineering. Volume 1 (1995)

The papers in this volume are divided into the following sections: DIII-D; MFE (Magnetic Fusion Energy) subsystem development; MFE materials, activation, and safety; MFE toroidal experiments; MFE reactor studies; IFMIF (International Fusion Materials Irradiation Facility)/materials irradiation; TPX design; alternative confinement; spherical configurations; magnet technology; fusion economics; heating and fueling; and anomalous reactions in solids. Separate abstracts were prepared for most papers in this volume.
Drug Targeting Mini-Symposium of the Division for Medicinal Chemistry (DMC) of the Swiss Chemical Society (SCS), at the Department of Chemistry, University of Basel, May 29, 2008 (2008)

Specific targeting of drugs to their respective target organs or tissues is challenging. Substantial research efforts have been undertaken in the recent past to develop target specific drugs or drug conjugates. Such concepts are most relevant in rather severe diseases like cancer since it helps to reduce the concentration of frequently rather toxic drugs outside the tumor tissue. Various techniques can be used to specifically direct a drug or a drug conjugate to a specific tumor tissue such as using antibodies directed against tumor specific proteins, as nanoparticles or nano-sized polymer conjugates carrying tumor-specific recognition elements or by applying the active drug principle in a prodrug form designed to be liberated specifically in tumor tissue. Three speakers from the academia and one speaker from industry described different approaches and their respective potentials from various perspectives in the lectures entitled: 'Polymer Therapeutics and other Nanomedicines as Targetable Cancer Therapies', 'Design, Application, and Chemical Biology of Tumor-Targeting Drug Conjugates', 'Antibody-Based Vascular Tumor Targeting: From the Bench to the Clinic', and 'Discovery of Capecitabine, a Rationally Designed and Tumor-Activated Oral Prodrug of 5-FU, and Beyond'.
Abstract C015: EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype and promotes immune surveillance in PDAC (2022)

Abstract T-cell based immunotherapies that produce durable and sometimes curative responses in other malignancies have failed in pancreatic ductal adenocarcinoma (PDAC) due to poor T cell infiltration and tumor immunogenicity. We and others have demonstrated that induction of cellular senescence and its accompanying senescence-associated secretory phenotype (SASP) can be a powerful way to enhance T cell infiltration into tumors and reactivate a different type of innate Natural Killer (NK) cell anti-tumor immunity that can mediate tumor control. Here, we found that the pancreas tumor microenvironment (TME) suppresses NK cell surveillance following therapy-induced senescence (TIS) with MEK and CDK4/6 inhibitor treatment through EZH2-mediated repression of pro-inflammatory SASP genes. Genetic or pharmacological inhibition of EZH2 or its methyltransferase activity enhanced the production of pro-inflammatory SASP factors and led to NK and T cell infiltration and immune-mediated tumor control in transplanted and genetically engineered PDAC mouse models. Mechanistically, EZH2 suppression induced expression of SASP factors CCL2 and CXCL9/10 necessary for lymophocyte chemotaxis into the pancreas TME. EZH2 levels were also associated with reduced NK cell numbers, SASP expression, and overall survival in a PDAC patient cohort. Taken together these results demonstrate that EZH2 mediates repression of the pro-inflammatory SASP in the pancreas TME, and that EZH2 blockade in combination with senescence-inducing therapies could be a powerful means to reactivate absent NK and T cell surveillance in PDAC to achieve immune-mediated tumor responses. Citation Format: Loretah Chibaya, Katherine C. Murphy, Yvette Lopez Diaz, Kelly D. DeMarco, Haibo Liu, Sneha Gopalan, Melissa Faulkner, Junhui Li, John P. Morris IV, Yu-jui Ho, Janelle Simon, Wei Luan, Amanda Kulick, Elisa de Stanchina, Karl Simin, Lihua J. Zhu, Thomas G. Fazzio, Scott W. Lowe, Marcus Ruscetti. EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype and promotes immune surveillance in PDAC [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer; 2022 Sep 13-16; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2022;82(22 Suppl):Abstract nr C015.
9.3: Active‐Matrix Organic Light Emitting Diode Using Inverse Staggered Poly‐Si TFT with a Center‐Offset Gated Structure (2009)

Abstract We have developed a low cost AM backplane using non‐laser polycrystalline silicon (poly‐Si) having inverse staggered TFT. The thin‐film transistors (TFTs) have a center‐offset gated structure to reduce the leakage current without scarifying the on‐currents. A center‐offset length of the TFTs has 3 μm for both switching and driving TFTs. Finally, we have made a 2.2 inch QQVGA (160 × 120) active‐matrix organic light emitting diode (AMOLED) display with conventional 2T 1C pixel circuits.
GTI at SemEval-2016 Task 5: SVM and CRF for Aspect Detection and Unsupervised Aspect-Based Sentiment Analysis (2016)

Tamara Álvarez-López, Jonathan Juncal-Martínez, Milagros Fernández-Gavilanes, Enrique Costa-Montenegro, Francisco Javier González-Castaño. Proceedings of the 10th International Workshop on Semantic Evaluation (SemEval-2016). 2016.
Operating modes of dual-grating dielectric laser accelerators (2020)

In this work, we present a comprehensive theoretical description of the Lorentz force in dual-grating dielectric laser accelerators (DLA). Here we examine the dual-grating DLA under arbitrary illumination conditions, both single-side and dual-side drive. We improve upon previous descriptions of these forces by providing a unified description of all possible operating modes of these devices, and classify the modes into three categories. In particular, we predict the existence of the previously observed ``line modes'' and a novel ``elliptical mode'', provide an experimental demonstration of this new mode, and suggest a possible application for it in improving the resolution of attosecond-scale streak cameras. Finally, we examine several complementary methods of tuning a dual-grating DLA to a desired operating mode---particularly dual-drive phase rotation and translational offset of the grating teeth.
Correction to “Characterization of a Radical S-Adenosyl-l-methionine Epimerase, NeoN, in the Last Step of Neomycin B Biosynthesis” (2014)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to “Characterization of a Radical S-Adenosyl-l-methionine Epimerase, NeoN, in the Last Step of Neomycin B Biosynthesis”Fumitaka Kudo*, Shota Hoshi, Taiki Kawashima, Toshiaki Kamachi, and Tadashi Eguchi*Cite this: J. Am. Chem. Soc. 2014, 136, 49, 17356Publication Date (Web):November 24, 2014Publication History Published online24 November 2014Published inissue 10 December 2014https://doi.org/10.1021/ja511223gCopyright © 2014 American Chemical SocietyRequest reuse permissions This publication is free to access through this site. Learn MoreArticle Views782Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (278 KB) Get e-Alertsclose Get e-Alerts
Data from Systemic Immune Dysfunction in Cancer Patients Driven by IL6 Induction of LAG3 in Peripheral CD8<sup>+</sup> T Cells (2023)

&lt;div&gt;Abstract&lt;p&gt;Many cancer patients do not develop a durable response to the current standard-of-care immunotherapies, despite substantial advances in targeting immune inhibitory receptors. A potential compounding issue, which may serve as an unappreciated, dominant resistance mechanism, is an inherent systemic immune dysfunction that is often associated with advanced cancer. Minimal response to inhibitory receptor (IR) blockade therapy and increased disease burden have been associated with peripheral CD8&lt;sup&gt;+&lt;/sup&gt; T-cell dysfunction, characterized by suboptimal T-cell proliferation and chronic expression of IRs (e.g., PD1 and LAG3). Here, we demonstrated that approximately a third of cancer patients analyzed in this study have peripheral CD8&lt;sup&gt;+&lt;/sup&gt; T cells that expressed robust intracellular LAG3 (LAG3&lt;sup&gt;IC&lt;/sup&gt;), but not surface LAG3 (LAG3&lt;sup&gt;SUR&lt;/sup&gt;) due to a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) cleavage. This is associated with poor disease prognosis and decreased CD8&lt;sup&gt;+&lt;/sup&gt; T-cell function, which could be partially reversed by anti-LAG3. Systemic immune dysfunction was restricted to CD8&lt;sup&gt;+&lt;/sup&gt; T cells, including, in some cases, a high percentage of peripheral naïve CD8&lt;sup&gt;+&lt;/sup&gt; T cells, and was driven by the cytokine IL6 via STAT3. These data suggest that additional studies are warranted to determine if the combination of increased LAG3&lt;sup&gt;IC&lt;/sup&gt; in peripheral CD8&lt;sup&gt;+&lt;/sup&gt; T cells and elevated systemic IL6 can serve as predictive biomarkers and identify which cancer patients may benefit from LAG3 blockade.&lt;/p&gt;&lt;/div&gt;
Side-Chain-Functionalized Polyacetylenes, 1. Liquid Crystalline and Stereomutational Properties (2002)

Stereospecific polymerizations of functionalized acetylenes were successfully performed using a Rh complex as the catalyst and triethylamine as a base yielding poly(3,4,5-tridodecyloxyphenylacetylene) (Poly5) and poly[3,4,5-tris((S)-3,7-dimethyloctyloxy)phenylacetylene] (Poly6). Poly5 and Poly6 are liquid crystalline with presumably a bilayer-type architecture in which the mesogens are arranged in an antiparallel overlapping interdigitated manner. Poly6 showed unusual thermal stereomutation in solution in a very narrow temperature range.
In vitro antibacterial activities of a novel oxazolidinone, OCID0050 (2009)

OCID0050 demonstrated better inhibitory potency against many of the tested clinically significant strains by generally showing 2-4-fold lower MICs than linezolid. In addition, it has higher inhibitory activity against linezolid-resistant strains.
Analysis of Food Toxins and Toxicants (2017)

Analysis of Food Toxins and Toxicants consists of five sections, providing up-to-date descriptions of the analytical approaches used to detect a range of food toxins. Part I reviews the recent developments in analytical technology including sample pre-treatment and food additives. Part II covers the novel analysis of microbial and plant toxins including plant pyrrolizidine alkaloids. Part III focuses on marine toxins in fish and shellfish. Part IV discusses biogenic amines and common food toxicants, such as pesticides and heavy metals. Part V summarizes quality assurance and the recent developments in regulatory limits for toxins, toxicants and allergens, including discussions on laboratory accreditation and reference materials.
Influence of ambient pressure on twin fluid atomization R&D work for high pressure entrained flow gasification (2012)

High pressure entrained flow gasification is a very promising technology for the conversion of low-grade fuels to a high quality syngas to be used for production of chemicals and chemical energy carriers, e.g. liquid fuels or SNG. High gasification efficiencies using liquid fuels or slurry can only be achieved through generation of a fine homogenous spray at high ambient pressure and low gas to liquid ratio (GLR). Influence of spray quality on gasification performance is demonstrated by experiments in an atmospheric Research Entrained flow GAsifier (REGA).The present work is therefore focused on the atomization of liquids at increased ambient pressure using an external mixing twin fluid nozzle, typical for entrained flow gasification. For the experimental work reported, ambient pressure is varied in the range of 2 – 16 bar using water as model fuel. Spray quality, i.e. drop size distribution and axial velocity distribution is detected by Shadow sizer and PDA-System, respectively. A high speed camera is used for qualitative investigation of primary atomization. The experiments show the influence of reactor pressure on spray quality in terms of SMD, for operational conditions at We = const. and alternatively at urel = const. Basic finding is that keeping the We-number constant is not enough to guarantee for constant atomization quality at varying reactor pressure, but the relative velocity has a dominant effect. The experimental results are discussed on the background of a short literature review.
Selectively transparent and conducting photonic crystals for advanced optoelectronics (2011)

A novel one-dimensional photonic crystal, called selectively transparent and conducting photonic crystal (STCPC), which integrates tunable optical and electrical properties is presented as a potential next-generation device element for advanced optoelectronics. A significant advance over existing 1D PCs, STCPCs combine intense wavelength selective broadband reflectance with the transmissive and electrical conductive properties of sputtered transparent conducting oxides. We review two applications which integrate STCPCs to enhance device performance; one, an STCPC based OLED microcavity, and two, an STCPC intermediate reflector in a micromorph tandem photovoltaic device. In both instances the STCPC, functioning as an electrode, providing the necessary electronic conductivity, and Bragg reflector, serves to enhance device performance.
Clinical Course and Prognosis in Mast Cell Proliferative Disorders: A 17 Year Experience in a Single Center. (2004)

Abstract In patients (pts) with mast cell (MC) proliferative disorders, the clinical course, prognosis, and outcome vary depending on age, organ-involvement, and the disease-variant. We have retrospectively analyzed the clinical course and outcome in 56 pts with MC disorders refered to the University of Vienna between 1987 and 2004. Using WHO criteria, pts were found to have cutaneous mastocytosis (CM, n=6), indolent systemic mastocytosis (ISM, n=35), aggressive SM (ASM, n=3), mast cell leukaemia (MCL, n=1), SM with associated clonal hematologic non-MC-lineage disease (SM-AHNMD, n=6), and myelomastocytic leukemia (MML, n=5). These groups differed from each other in serum tryptase levels, hemoglobin, platelet counts, and lactate dehydrogenase (p&amp;lt;0.05). By contrast, no significant differences were found in white blood cells, eosinophils, monocytes, or presence of the c-kit mutation D816V. Most pts with ISM showed a stable clinical course without signs of progression or increase in serum tryptase even when monitored for more than a decade. By contrast, in all pts with ASM, MCL, SM-AHNMD, and MML, the neoplasm progressed after a latency period of several months. The median event-free survival was 3.7 months in pts with ASM/MCL, 22.8 months in SM-AHNMD, and 5.0 months in MML. In CM and ISM, the median survival was not reached. The differences in event-free survival among WHO groups were found to be significant (p&amp;lt;0.05). Apart from high grade WHO categories, adverse prognostic variables concerning survival were i. absence of skin-lesions, ii. high percentage (&amp;gt;5%) of MC in bone marrow smears, and iii. splenomegaly. Polychemotherapy resulted in complete remission in MML, but not in ASM or MCL. Interferon-alpha and 2CdA showed cytoreductive effects in some pts with ASM, but did not work in MCL. For the latter group of pts new therapies need to be developed.
Metabolic evaluation of sporadic papillary kidney cancer. (2012)

377 Background: Papillary kidney cancer, which occurs in 15% of patients with kidney cancer, can be aggressive and there is currently no effective form of therapy for this disease. To evaluate the metabolic characteristics of sporadic papillary kidney cancer, we have evaluated metabolic parameters of several papillary kidney cancer cell lines and available gene expression profiles. Methods: Established cell lines derived from patients with sporadic papillary kidney cancer (LABAZ, MDACC-55, HRC-86T2) and from a hereditary form of fumarate hydratase-deficient kidney cancer (UOK262) were evaluated. All sporadic lines were initially sequenced for fumarate hydratase (FH). All cell lines were metabolically profiled using the Seahorse Extracellular Flux Analyzer and further evaluated for reactive oxygen species (ROS), mitochondrial membrane potential, and glucose dependence. Finally gene expression profiles of publically available datasets of papillary and HLRCC tumors were downloaded, normalized, and analyzed. Results: Sporadic lines had no alterations in FH and metabolic analysis demonstrated normal oxygen consumption and minimal lactate production, in contrast to highly glycolytic UOK262. Also unlike UOK262, the sporadic papillary kidney cancer lines were not sensitive to glucose withdrawal, had low levels of ROS, and had normal mitochondria membrane potential. Principal component analysis (PCA) demonstrated that HLRCC tumor specimens are very different from sporadic papillary tumors at the molecular level. Conclusions: Our study of established sporadic papillary RCC and fumarate hydratase-deficient HLRCC cell line together with analysis of available gene expression profiles demonstrates that these sporadic papillary kidney cancer cell lines appear to have a distinct metabolic profile from those in the fumarate hydratase deficient kidney cancer cell line. Understanding the metabolic basis of papillary kidney cancer could provide the foundation for the development of targeted approaches to therapy for patients with this disease.
Towards Identification for Harmonic Transponders (2022)

In this paper we present a technique allowing to identify harmonic transponders. The approach relies on the evolution of the backscattered power at a given harmonic frequency as a function of the fundamental frequency. Thus to identify an harmonic transponder, the associated reader sweeps a continuous wave in the considered bandwidth. Experiments are done based on a vector network analyzer, the method is able to identify two different RECCO reflectors. A study on the read range is also included. These harmonic transponders allow to drastically increase the read range compared to the one associated to linear time-invariant systems such as chipless tags.
Temperature dependence of photoluminescence in porous silicon and its interpretation using the porous-cluster model (1995)

Photoluminescence (PL) of porous silicon in the redband is studied at temperatures from 15 to 293 K. With increasing temperature, the PL spectrum peak redshifts and the width narrows, while the PL intensity increases until \ensuremath{\sim}70 K and then decreases slightly. At 293 K, the PL at higher emission energy decays faster with a broader rate distribution. The PL decay gets slower upon cooling, and becomes independent of emission energy below \ensuremath{\sim}70 K. These results are qualitatively interpreted using a porous-cluster model that assumes random vacancy sites in a Si lattice. The low-temperature PL can be explained by carrier recombination through localized states which are distributed in energy, and dimensionally disordered. The changes in the PL with temperature, on the other hand, are understood by thermal activation of recombination processes, including hopping of carriers among distributed localized states.
Supplemental Table 1 from AGS16F Is a Novel Antibody Drug Conjugate Directed against ENPP3 for the Treatment of Renal Cell Carcinoma (2023)

&lt;p&gt;Supplemental Table 1. Quantification of ENPP3 Expression in Various Carcinomas&lt;/p&gt;
The hypolipidemic effect of lifibrol during a long term treatment of pigs. (1990)

We investigated the hypolipidemic property of lifibrol in male and female minipigs in a long term trial over a treatment period of 6 months. Oral dosages between 12.5 mg/kg BW and 100 mg/kg BW lifibrol resulted in a strong reduction of serum cholesterol after only two weeks of treatment. The hypocholesterolemic effect was not counterbalanced and reached -76% at the end of the trial in the male pigs and -70% in the female pigs (100 mg/kg BW lifibrol). The reduction of serum cholesterol was mainly brought about by the reduction of LDL-cholesterol. Serum triglycerides seemed to be less influenced by lifibrol than serum cholesterol. The application of lifibrol had no significant influence on the weight gain of the pigs and did not alter the serum levels of AST and ALT. Lifibrol was well tolerated and the animals showed no symptoms of incompatibility.
How quantum theory is developing the field of Information Retrieval (2010)

This position paper provides an overview of work conducted and an outlook of future directions within the field of Information Retrieval (IR) that aims to develop novel models, methods and frameworks inspired by Quantum Theory (QT).