gebhart/patrepeval huggingface dataset:
Ultraviolet absorption spectra of gaseous tin difluoride and lead difluoride (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUltraviolet absorption spectra of gaseous tin difluoride and lead difluorideRobert H. Hauge, J. W. Hastie, and J. L. MargraveCite this: J. Phys. Chem. 1968, 72, 10, 3510–3511Publication Date (Print):October 1, 1968Publication History Published online1 May 2002Published inissue 1 October 1968https://pubs.acs.org/doi/10.1021/j100856a025https://doi.org/10.1021/j100856a025research-articleACS PublicationsRequest reuse permissionsArticle Views51Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Label-free Quantification of Pharmacokinetics in Skin (2019)

Using coherent Raman imaging and deep learning, we have visualized and quantified the pharmacokinetics of drugs in the skin. This spatially and temporally-resolved approach has shed light on the mechanisms of vehicle and drug kinetics.
Risks and Benefits of Side-Channels in Battlefields (2018)

As networked devices and applications make their way into our battlefields, their behaviors need to take into account these highly adversarial cyber-physical environments. On the dark side of the spectrum, undesired side-channels put our sensitive data at risk; hence, side-channel-protected devices and implementations should be promoted. On the bright side of the spectrum, side-channel analysis may be correlated with observed and hidden events, and enable causality inference and watermarking. This paper describes some unique risks and benefits that may be obtained from side-channel analyses in battlefields.
Mspl RFLP for microtubule associated protein-2 (MAP2) (1991)

The MAP2 probe (KN7) used was a 2.4 kb partial cDNA in the EcoRI site of pBR322. The probe was supplied by R. Neve (1).
Assessing Changes in Human Gait with a Mobile Tethered Pelvic Assist Device (mTPAD) in Transparent Mode with Hand Holding Conditions (2022)

Robotic gait trainers provide the capability for gait training while adding the application of repeatable forces to specific joints or segments of the user's body. These robotic devices, in principle, should make minimal alterations to the user's natural gait. Hence, the transparency of each device needs to be evaluated. This work explores the effects of walking in a mobile Tethered Pelvic Assist Device (mTPAD) in a zero-force mode. Eight neuro-typical adults walked in three conditions to evaluate changes in their natural gait due to the device and holding its handrails. The changes in spatial and temporal gait parameters and lower limb and arm muscle activations were characterized. Our results showed that walking in mTPAD in a zero-force mode was not significantly different from baseline treadmill walking for all recorded peak muscle activations and gait parameters, highlighting the mTPAD's transparency. When the users hold the device's frame, peak bicep activation increases, and the users take slower, narrower steps. However, frame holding did not significantly alter any lower limb peak muscle activations. This work verifies the transparency of the mTPAD's zero-vertical force controller and isolates changes in the muscle activations and gait patterns caused by holding the device's frame. This investigation can motivate the design and control of other user-propelled robotic gait trainers. This work also allows future studies with mTPAD to separate gait changes caused by force interventions from changes due to holding the device.
67.2: Compensation Methods for Local‐Dimming Backlights with RGB‐LED (2010)

Abstract In LED backlight system with high optical independence inside a segmented block, using individually controllable RGB‐LED as light source, we can obtain the advantage of wider color gamut, lower power consumption, and wider range of LCD expression than using white‐LED. On the other hand, there are problems of influence on luminance uniformity and chromaticity uniformity caused by the device‐to‐device variations, temperature property, and age‐related deterioration in the use of RGB‐LED. Additionally, power loss and heat generation which depend on temperature property of LED forward voltage (V f ) are problems. Therefore, it is difficult to develop the LED backlight that shines uniformly with good power efficiency. To solve those problems, we develop and evaluate compensation methods such as Optical unevenness correction, Thermal feedback control, Photo‐feedback control, and LED‐applied voltage control.
Inhibition of inflammation but not ankylosis by glucocorticoids in mice: further evidence for the entheseal stress hypothesis (2012)

BMP signaling may be a trigger for both inflammation and ankylosis in the spontaneous model of ankylosing enthesitis. The lack of inhibition by glucocorticoids on new bone formation while causing systemic bone loss highlights the paradoxical simultaneous loss and gain of bone in patients with ankylosing spondylitis.
Hydrophone Spatial Averaging Artifacts for ARFI Beams from Array Transducers (2020)

This paper reports underestimation of peak compressional pressure (<i>p</i> <sub>c</sub>), peak rarefactional pressure (<i>p</i> <sub><i>r</i></sub> ), and pulse intensity integral (<i>pii</i>) due to hydrophone spatial averaging of acoustic radiation force impulse (ARFI) beams generated by clinical linear and phased arrays. Although a method exists for correcting for hydrophone spatial averaging for circularly-symmetric beams, there is presently no analogous method for rectangularly-symmetric beams generated by linear and phased arrays. Consequently, pressure parameters (<i>p</i> <sub>c</sub>, <i>p</i> <sub><i>r</i></sub> , and <i>pii</i>) from clinical arrays are often not corrected for spatial averaging. This can lead to errors in Mechanical Index (MI) and Thermal Index (TI), which are derived from pressure measurements and are displayed in real-time during clinical ultrasound scans. ARFI beams were generated using three clinical linear array transducers. Output pressure waveforms for all three transducers were measured using five hydrophones with geometrical sensitive element sizes (d<sub>g</sub>) ranging from 85 to 1000 μm. Spatial averaging errors were found to increase with hydrophone sensitive element size. For example, if d<sub>g</sub> = 500 μm (typical membrane hydrophone), frequency = 2.25 MHz and F/# = 1.5, then average errors are approximately -20% (p<sub>c</sub>), -10% (p<sub>r</sub>), and -25% (pii). Therefore, due to hydrophone spatial averaging, typical membrane hydrophones can exhibit significant underestimation of ARFI pressure measurements, which likely compromises exposure safety indexes.
Sequences of herpes simplex virus type 1 that inhibit formation of stable TK+ transformants (1987)

We have identified two regions of the herpes simplex virus type 1 (HSV-1) genome that inhibit DNA-mediated transformation of thymidine kinase-less L (Ltk-) cells by the cloned HSV-1 tk gene. When plasmids containing the EcoRI fragments EK or JK were mixed at 30 fmol/ml with the tk gene and transfected into Ltk- cells, the frequency of transformation was inhibited 80 to more than 90% relative to the control. Of the remaining 10 EcoRI fragments of the HSV-1 genome, 8 were inactive and 2 were weakly active. A 6.1-kilobase PstI subclone between 0.743 and 0.782 map units was isolated from pEK. This clone, pEK-P3P4, exhibited antitransformation activity toward HSV-1 tk and also the bacterial genes gpt and neo. pEK-P3P4 contains the alpha 27 gene, and restriction endonuclease inactivation and subcloning studies established that alpha 27 alone did not inhibit transformation. However, alpha 27 plus sequences both upstream and downstream of alpha 27 did inhibit transformation. In addition, alpha 0 or alpha 4 could substitute for alpha 27 in effecting antitransformation with these sequences. Therefore, an alpha gene and two additional loci in pEK-P3P4 are required for antitransformation. A second antitransforming locus in the reiterated sequences common to EK and JK and distinct from those in pEK-P3P4 was also identified but not characterized in detail. How antitransformation may be an expression of regulation of viral and host cell gene expression is discussed.
Analysis of an Adaptive P-Persistent MAC Scheme for WLAN Providing Delay Fairness (2010)

The paper proposes and analyzes an adaptive p-persistent-based (APP) medium access control (MAC) scheme for IEEE 802.11 WLAN. The APP MAC scheme intends to support delay fairness for every station in each access, denoting small delay variance. It differentiates permission probabilities of transmission for stations which are incurred with various packet delays. This permission probability is designed as a function of the numbers of retransmissions and re-backoffs so that stations with larger packet delay are endowed with higher permission probability. Also, the scheme is analyzed by a Markov-chain analysis, where the collision probability, the system throughput, and the average delay are successfully obtained. Numerical results show that the proposed APP MAC scheme can attain lower mean delay and higher mean throughput. In the mean time, simulation results are given to justify the validity of the analysis, and also show that the APP MAC scheme can achieve more delay fairness than conventional algorithms.
Applying Molecular Networking for the Detection of Natural Sources and Analogues of the Selective Gq Protein Inhibitor FR900359 (2018)

The cyclic depsipeptide FR900359 (FR), isolated from the traditional Chinese medicine plant Ardisia crenata, is a potent Gq protein inhibitor and thus a valuable tool to study Gq-mediated signaling of G protein-coupled receptors. Two new FR analogues (3 and 4) were isolated from A. crenata together with the known analogues 1 and 2. The structures of compounds 3 and 4 were established by NMR spectroscopic data and MS-based molecular networking followed by in-depth LCMS<sup>2</sup> analysis. The latter approach led to the annotation of further FR analogues 5-9. Comparative bioactivity tests of compounds 1-4 along with the parent molecule FR showed high-affinity binding to Gq proteins in the low nanomolar range (IC<sub>50</sub> = 2.3-16.8 nM) for all analogues as well as equipotent inhibition of Gq signaling, which gives important SAR insights into this valuable natural product. Additionally, FR was detected from leaves of five other Ardisia species, among them the non-nodulated leaves of Ardisia lucida, implying a much broader distribution of FR than originally anticipated.
Induced pluripotent stem cells display a distinct set of MHC I-associated peptides shared by human cancers (2022)

Previous reports showed that mouse vaccination with pluripotent stem cells (PSCs) induces durable anti-tumor immune responses via T cell recognition of some elusive oncofetal epitopes. We characterize the MHC I-associated peptide (MAP) repertoire of human induced PSCs (iPSCs) using proteogenomics. Our analyses reveal a set of 46 pluripotency-associated MAPs (paMAPs) absent from the transcriptome of normal tissues and adult stem cells but expressed in PSCs and multiple adult cancers. These paMAPs derive from coding and allegedly non-coding (48%) transcripts involved in pluripotency maintenance, and their expression in The Cancer Genome Atlas samples correlates with source gene hypomethylation and genomic aberrations common across cancer types. We find that several of these paMAPs were immunogenic. However, paMAP expression in tumors coincides with activation of pathways instrumental in immune evasion (WNT, TGF-β, and CDK4/6). We propose that currently available inhibitors of these pathways could synergize with immune targeting of paMAPs for the treatment of poorly differentiated cancers.
A future energy supply based on Liquid Organic Hydrogen Carriers (LOHC) (2011)

This contribution describes a concept for the establishment of a competitive energy distribution network based on Liquid Organic Hydrogen Carrier (LOHC) compounds. These compounds are characterized by the fact that they can be loaded and un-loaded with considerable amounts of hydrogen in a cyclic process. This concept links the technical challenge of storing temporary and local energy over-production from regenerative sources with the vision of a sustainable, hydrogen-based mobility. The proposed LOHC compounds have many physico-chemical similarities to diesel. Thus, LOHCs could make use of the existing energy infrastructure (e.g. tank ships, storage tanks or fueling stations) and enable a slow and step-wise replacement of the existing hydrocarbon fuels by alternative LOHC fuels. We consider LOHCs as an attractive way to provide wind and solar energy for mobility applications in the form of liquid energy carrying molecules of similar energy storage densities and manageability as today's fossil fuels.
An empirical approach for fake user detection in location-based social networks (2017)

Location-based social networks are becoming a unique platform for understanding user behaviors and providing pervasive services in intelligent environments. However, fake users or accounts can undermine user analytics and lower the value of the applications and services intended for real users. Min ing a large Foursquare dataset and related Twitter accounts, we tested different user features with the goal of classifying fake users. Experiments demonstrate an accuracy over 95% in detecting fake users. Filtering out these fake users reduces the error rate of a location-based activity predictor by a 4.4% and avoids wasting 35% of coupons or promotion codes delivery if applied to a recommender system.
Modular Strategy for the Construction of Radiometalated Antibodies for Positron Emission Tomography Based on Inverse Electron Demand Diels–Alder Click Chemistry (2011)

A modular system for the construction of radiometalated antibodies was developed based on the bioorthogonal cycloaddition reaction between 3-(4-benzylamino)-1,2,4,5-tetrazine and the strained dienophile norbornene. The well-characterized, HER2-specific antibody trastuzumab and the positron emitting radioisotopes (64)Cu and (89)Zr were employed as a model system. The antibody was first covalently coupled to norbornene, and this stock of norbornene-modified antibody was then reacted with tetrazines bearing the chelators 1,4,7,10-tetraazacyclo-dodecane-1,4,7,10-tetraacetic acid (DOTA) or desferrioxamine (DFO) and subsequently radiometalated with (64)Cu and (89)Zr, respectively. The modification strategy is simple and robust, and the resultant radiometalated constructs were obtained in high specific activity (2.7-5.3 mCi/mg). For a given initial stoichiometric ratio of norbornene to antibody, the (64)Cu-DOTA- and (89)Zr-DFO-based probes were shown to be nearly identical in terms of stability, the number of chelates per antibody, and immunoreactivity (>93% in all cases). In vivo PET imaging and acute biodistribution experiments revealed significant, specific uptake of the (64)Cu- and (89)Zr-trastuzumab bioconjugates in HER2-positive BT-474 xenografts, with little background uptake in HER2-negative MDA-MB-468 xenografts or other tissues. This modular system-one in which the divergent point is a single covalently modified antibody stock that can be reacted selectively with various chelators-will allow for both greater versatility and more facile cross-comparisons in the development of antibody-based radiopharmaceuticals.
Response to “Comment on ‘On the mechanism of the cubic phase formation in the boron nitride thin-film systems’ ” [Appl. Phys. Lett. 80, 1306 (2002)] (2002)

First Page
Supplementary Figure S5 from A Clinical PET Imaging Tracer ([<sup>18</sup>F]DASA-23) to Monitor Pyruvate Kinase M2–Induced Glycolytic Reprogramming in Glioblastoma (2023)

&lt;p&gt;Post-therapy Imaging of IC-1&lt;/p&gt;
Virus-Enabled Biosensor for Human Serum Albumin (2016)

The label-free detection of human serum albumin (HSA) in aqueous buffer is demonstrated using a simple, monolithic, two-electrode electrochemical biosensor. In this device, both millimeter-scale electrodes are coated with a thin layer of a composite containing M13 virus particles and the electronically conductive polymer poly(3,4-ethylenedioxy thiophene) or PEDOT. These virus particles, engineered to selectively bind HSA, serve as receptors in this biosensor. The resistance component of the electrical impedance, Z<sub>re</sub>, measured between these two electrodes provides electrical transduction of HSA binding to the virus-PEDOT film. The analysis of sample volumes as small as 50 μL is made possible using a microfluidic cell. Upon exposure to HSA, virus-PEDOT films show a prompt increase in Z<sub>re</sub> within 5 s and a stable Z<sub>re</sub> signal within 15 min. HSA concentrations in the range from 100 nM to 5 μM are detectable. Sensor-to-sensor reproducibility of the HSA measurement is characterized by a coefficient-of-variance (COV) ranging from 2% to 8% across this entire concentration range. In addition, virus-PEDOT sensors successfully detected HSA in synthetic urine solutions.
Monolithically integrated quantum dot optical gain modulator with semiconductor optical amplifier for 10-Gb/s photonic transmission (2015)

Short-range interconnection and/or data center networks require high capacity and a large number of channels in order to support numerous connections. Solutions employed to meet these requirements involve the use of alternative wavebands to increase the usable optical frequency range. We recently proposed the use of the T- and O-bands (Thousand band: 1000–1260 nm, Original band: 1260–1360 nm) as alternative wavebands because large optical frequency resources (&gt;60 THz) can be easily employed. In addition, a simple and compact Gb/s-order high-speed optical modulator is a critical photonic device for short-range communications. Therefore, to develop an optical modulator that acts as a highfunctional photonic device, we focused on the use of self-assembled quantum dots (QDs) as a three-dimensional (3D) confined structure because QD structures are highly suitable for realizing broadband optical gain media in the T+O bands. In this study, we use the high-quality broadband QD optical gain to develop a monolithically integrated QD optical gain modulator (QD-OGM) device that has a semiconductor optical amplifier (QD-SOA) for Gb/s-order highspeed optical data generation in the 1.3-μm waveband. The insertion loss of the device can be compensated through the SOA, and we obtained an optical gain change of up to ~7 dB in the OGM section. Further, we successfully demonstrate a 10-Gb/s clear eye opening using the QD-OGM/SOA device with a clock-data recovery sequence at the receiver end. These results suggest that the monolithic QD-EOM/SOA is suitable for increasing the number of wavelength channels for smart short-range communications.
Supplementary Figs from MAPK Activation Predicts Poor Outcome and the MEK Inhibitor, Selumetinib, Reverses Antiestrogen Resistance in ER-Positive High-Grade Serous Ovarian Cancer (2023)

&lt;p&gt;Supplementary Figure 1. (A) Percent of HGSOCs from the TCGA cohort with mutations in 42 genes associated with the RAS/Raf/MEK/MAPK pathway (N=45/311); (B) Percent of HGSOCs from the TCGA cohort with copy number amplifications or mRNA overexpression of 42 MAPK pathway genes (N=232/311) Supplementary Figure 2. (A); Percent of high-pMAPK and low-pMAPK HGSOCs as defined by RPPA from the TCGA cohort with (A) copy number amplification (B) mRNA overexpression, (C) mutation in which MAPK pathway genes are genetically activated in hMAPK cancers. The numbers with data available for each analysis in TCGA are shown below graphs. Supplementary Figure 3. Dose dependent effects of selumetinib on ER positive, MAPK kinase activated ovarian cancer cells Supplementary Figure 4. In vitro cell cycle effects of MEK and ER inhibition on ER+ BG-1 OVCA cells Supplementary Figure 5: Gene expression changes expressed as log fold change over baseline control untreated cell values after 48 hours of treatment with fulvestrant (1 μM), selumetinib (200 nM) or both, in vitro of representative genes in (A) ER target gene expression (B) Cell signaling pathways (C) Cell cycle pathways. Supplementary Figure 6. Heat map representation of selected triplicate repeat RPPA data from PEO1-R cells treated with either monotherapy fulvestrant (FULV), selumetinib (MEK I) or dual therapy as indicated. Heat map demonstrates inter-sample variability in triplicate repeat assays. Supplementary Table 1. List of genes in the 126 gene MAPK activation profile common to the TCGA and JAPAN cohorts. Supplementary Table 2. Differences in gene mutation, overexpression and amplification between low and high pMAPK HGSOC as defined by RPPA in TCGA cohort Supplementary Table 3.Analysis of xenograft growth rates reveal synergy between fulvestrant and selumetinib therapy on OVCA PEOIR xenograft growth&lt;/p&gt;
Effects of HIV-1 Tat on Enteric Neuropathogenesis (2014)

The gastrointestinal (GI) tract presents a major site of immune modulation by HIV, resulting in significant morbidity. Most GI processes affected during HIV infection are regulated by the enteric nervous system. HIV has been identified in GI histologic specimens in up to 40% of patients, and the presence of viral proteins, including the trans-activator of transcription (Tat), has been reported in the gut indicating that HIV itself may be an indirect gut pathogen. Little is known of how Tat affects the enteric nervous system. Here we investigated the effects of the Tat protein on enteric neuronal excitability, proinflammatory cytokine release, and its overall effect on GI motility. Direct application of Tat (100 nm) increased the number of action potentials and reduced the threshold for action potential initiation in isolated myenteric neurons. This effect persisted in neurons pretreated with Tat for 3 d (19 of 20) and in neurons isolated from Tat(+) (Tat-expressing) transgenic mice. Tat increased sodium channel isoforms Nav1.7 and Nav1.8 levels. This increase was accompanied by an increase in sodium current density and a leftward shift in the sodium channel activation voltage. RANTES, IL-6, and IL-1β, but not TNF-α, were enhanced by Tat. Intestinal transit and cecal water content were also significantly higher in Tat(+) transgenic mice than Tat(-) littermates (controls). Together, these findings show that Tat has a direct and persistent effect on enteric neuronal excitability, and together with its effect on proinflammatory cytokines, regulates gut motility, thereby contributing to GI dysmotilities reported in HIV patients.