gebhart/patrepeval huggingface dataset:
Acoustic-wave-lumped-element resonator (AWLR) architectures for high-Q reflective bandstop filters (2015)

The RF design of a new family of reflective-type bandstop filters (BSFs) with small form factor, narrow bandwidth (BW) and large stopband attenuation is presented in this paper. The proposed filter geometries are based on mixed acoustic-wave-lumped-element resonator (AWLR) architectures that are effectively combined with lumped-element impedance inverters. Contrary to conventional all-AW filter topologies, the achieved stopband BW is no longer limited by the electromechanical coupling coefficient (kt2) of the acoustic wave (AW) resonator. Furthermore, their resulting stopbands exhibit effective quality factors (Qseff) that are at least 50 times higher than in traditional lumped-element filters. First- and second-order BSF prototypes that consist of commercially-available surface acoustic wave (SAW) resonators and surface mounted devices (SMDs) have been designed, built and measured at 418 MHz. Measured stopbands with 3dB-BWs between 0.25 MHz and 0.72 MHz, maximum stopband attenuation ranging from 20 to 30 dB, and passband loss between 0.4 and 1 dB are presented as proof-of-concept demonstrators.
On-Chip Testing Techniques for RF Wireless Transceivers (2006)

This article describes a set of on-chip testing techniques and their application to integrated wireless RF transceivers. The objective is to reduce final product cost and accelerate time to market by providing means of testing the entire transceiver system as well as its major building blocks without using off-chip analog or RF instrumentation. On-chip test devices fabricated in a standard CMOS process and experimentally evaluated support the proposed test strategy
Properties of nitrocellulose‐coated and polyethylene‐laminated chitosan and whey films (2001)

Chitosan (chitosan acetic acid salt) and whey (65% protein) films were coated with a nitrocellulose lacquer or laminated with polyethylene to enhance their water resistance and gas barrier properties in humid environments. The barrier properties were measured by the Cobb60 test and water-vapor (100% relative humidity) transmission and oxygen (90% relative humidity) permeability tests. Mechanical properties were obtained with tensile tests. Packaging properties were studied with crease and folding tests. The Cobb60 test revealed that the coated films were resistant to liquid water, at least for a short exposure time, if the coating thickness was at least 10–17 μm. Water-vapor transmission rates comparable to those of polyethylene-laminated films were obtained for coated chitosan at a coating thickness of 5–7 μm. The coated films possessed low oxygen permeability despite the high humidity. Coated films dried for 3 weeks showed oxygen permeabilities at 90% relative humidity that were similar to values for dry ethylene-co-vinyl alcohol at 0% relative humidity. The lacquer partly penetrated the whey films, and this led to excellent adhesion but poor lacquer toughness. The lacquer coating on chitosan was tougher, and it was possible to fold these films 90° without the coating fracturing if the coating thickness was small. The coated whey films were readily creasable. © 2001 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 39: 985–992, 2001
[The clinical and echocardiographic factors predictive of bioprosthetic leaflet rupture. The clinical tolerance for prosthetic malfunction]. (1994)

No echocardiographic features were found as being predictors of imminent bioprosthetic disruption. However, leaflet thickness is the most common finding. Symptoms of disruption in patients without high surgical risk factors (left ventricular dysfunction or pulmonary hypertension) are kept under control with medical treatment. Therefore, "prophylactic" surgery is not needed in bioprosthesis with signs of degeneration and normal hemodynamic performance.
One‐Pot Preparation of [n]Ladderanes by [2π + 2π] Photocycloaddition (2005)

Abstract A new method for the preparation of [ n ]ladderanes is presented, based on a one‐pot [2π+2π] photocycloaddition of [2.2]paracyclophane pseudo‐ gem bis(polyene) precursors. [3]‐ and [5]ladderanes could be isolated and were fully characterized, including their X‐ray structure analysis. The overall chemical yields from [2.2]paracyclophane as starting material were found to be 53 % ([3]ladderane) and 38 % ([5]ladderane). Preliminary investigations of their photochromic properties (reversible change from yellow or red to colourless forms) are described. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2005)
Deficiency of the lysosomal exonuclease PLD3 impacts the degradative route (2021)

Background Phospholipase D3 (PLD3) is a 5'-3' exonuclease that resides in lysosomes where it is implicated in the regulation of inflammatory responses by degrading ssDNA. Polymorphisms in the PLD3 gene have been linked to late-onset Alzheimer’s disease (LOAD; Cruchaga et al., PMID: 24336208), but contradictory data exist on the impact of PLD3 deficiency on APP processing. Given PLD3 is primarily expressed in neurons within the brain, we were interested in exploring its role in neuronal endolysosomal homeostasis. Method We generated PLD3-/- neuroblastoma SH-SY5Y clonal cell lines, using Crispr/cas9 gene editing, that were subsequently stably rescued with lentiviral vector technology. For this, the wild-type PLD3 sequence was compared to variants harbouring LOAD-associated risk single-nucleotide polymorphisms (SNPs), including M6R, K228R, V232M, N236S, N284S and T426A. PLD3 exonuclease kinetics towards different substrates were measured using EFQO assays (Cappel et al., PMID: 33288674). Autophagy and mitophagy dysregulations, as possible important catalysts for DNA delivery to lysosomes, were further scrutinized with biochemical assays and confocal imaging. In parallel, we investigated the endolysosomal morphology by electron microscopy. Result Firstly, most SNP variants, except the M6R and T426A variants, display a significantly reduced exonuclease activity; indicating a loss-of-function for these variants. Overall, knock-out of PLD3 leads to elevations in lysosomal and autophagosomal components, including a defect in mitophagy, lysosomal cholesterol accumulation and an accretion of the uncleaved/inactive CatD. These aberrant features can be rescued by re-introducing wild-type PLD3, but not PLD3 SNP-variants. This underscores a critical role for PLD3 in lysosomal homeostasis, likely mediated through its exonuclease activity. Given different variants elicit different exonuclease kinetics towards different ssDNA substrates, this suggests that PLD3 contributes to upholding lysosomal DNA levels within a narrow range, which is required for a normal lysosomal proteostasis. Conclusion PLD3 depletion and exonuclease dysfunction-causing SNPs promote lysosomal impairment and, as such, a congestion of the degradative route. We hypothesize that this could relate to a dysfunctional exonuclease activity of PLD3 in lysosomes. Given the observation of engulfed mitochondria within autophagosomes, the substrates for PLD3 could potentially come from mtDNA.
Low-rank pilot-symbol-aided channel estimation for MIMO-OFDM systems (2005)

In this paper, we propose a low-rank pilot-symbol-aided (PSA) channel estimator for multiple-input multiple-output orthogonal frequency division multiplexing (MIMO-OFDM) systems. Group-wise pilot patterns are also proposed for the low-rank channel estimator. We evaluate the performance of the proposed low-rank channel estimator for various mobile channel environments by computer simulation. It is shown than the proposed channel estimator has better performance than the conventional 2D PSA channel estimator without increase of computational complexity and pilot overhead.
A phase 1b study of transforming growth factor-beta receptor I inhibitor galunisertib in combination with sorafenib in Japanese patients with unresectable hepatocellular carcinoma (2018)

Background Galunisertib inhibits type I transforming growth factor-beta receptor serine/threonine kinase. The primary objective of this study was to evaluate the safety and tolerability of galunisertib in combination with sorafenib in Japanese patients with unresectable hepatocellular carcinoma. Patients and methods This open-label, dose-escalation, multicenter, nonrandomized phase 1b study consisted of two dose levels of galunisertib, 160 or 300 mg/day, in combination with sorafenib 800 mg/day. Galunisertib 80 mg or 150 mg was administered orally twice daily for 14 days followed by 14 days of rest plus sorafenib 400 mg administered orally twice daily for 28 days. The dose-limiting toxicity evaluation was 28 days after the first dose. Safety measures, pharmacokinetics, and antitumor activity were assessed. Results Fourteen patients, 7 at each galunisertib dose, were enrolled and treated. Three dose-limiting toxicities were reported for 2 patients. The most common treatment-emergent adverse events (TEAEs) were hypophosphatemia (14 patients [100%]), palmar-plantar erythrodysesthesia syndrome (12 patients [85.7%]), and decreased platelet count (10 patients [71.4%]). The most common grade ≥ 3 TEAEs were hypophosphatemia (10 patients [71.4%]) and palmar-plantar erythrodysesthesia syndrome (7 patients [50.0%]). No grade 5 TEAEs were reported. The pharmacokinetic profile of galunisertib in combination with sorafenib was similar to that previously reported for galunisertib. Eleven patients had a best overall response of stable disease, and 1 patient achieved a partial response by hepatocellular carcinoma-specific modified RECIST. Conclusions These data are consistent with the known safety profile for galunisertib and sorafenib and confirm tolerability of the recommended dose of galunisertib (150 mg twice daily for 14 days) in combination with sorafenib in Japanese patients with unresectable hepatocellular carcinoma.
Experimental investigation of RZ-8DPSK at 3×10.7 Gb/s (2005)

We experimentally determine the required OSNR and dispersion tolerance of RZ-8DPSK at 32.1Gb/s. We show a 1dB dispersion tolerance of 600ps/nm and an OSNR penalty of 6.7dB compared to RZ-DQPSK at the same symbol rate.
Big Learning with Bayesian methods (2017)

Abstract The explosive growth in data volume and the availability of cheap computing resources have sparked increasing interest in Big learning, an emerging subfield that studies scalable machine learning algorithms, systems and applications with Big Data. Bayesian methods represent one important class of statistical methods for machine learning, with substantial recent developments on adaptive, flexible and scalable Bayesian learning. This article provides a survey of the recent advances in Big learning with Bayesian methods, termed Big Bayesian Learning, including non-parametric Bayesian methods for adaptively inferring model complexity, regularized Bayesian inference for improving the flexibility via posterior regularization, and scalable algorithms and systems based on stochastic subsampling and distributed computing for dealing with large-scale applications. We also provide various new perspectives on the large-scale Bayesian modeling and inference.
Synthesis of the Functionalized Cyclohexanecarbaldehyde Derivative. A Potential Key Compound for Total Synthesis of Optically Active Tetrodotoxin (1991)

Abstract Oxidation of 1L-(1,2,3′,4,5/3,6)-3-hydroxymethyl-2,4,5-tri-O-methoxymethyl-3,3′-O-methylene-6-nitro-2,3,4,5-tetrahydroxycyclohexanecarbaldehyde dimethyl acetal with potassium t-butoxide and m-chloroperbenzoic acid has given corresponding carbonyl derivative in 65% yield. The carbonyl compound has been successfully converted into the desired key compound for tetrodotoxin synthesis in excellent yield via the spiro α-chloro-epoxide derivative.
Control of a&lt;tex&gt;$Z$&lt;/tex&gt;-Axis MEMS Vibrational Gyroscope (2005)

This paper describes the design of the control loops in a z-axis, MEMS vibrational gyroscope operating in a vacuum enclosure. In this device, a silicon mass is driven through electrostatic actuator so that it has a sinusoidal linear motion, with a controlled speed. The design of a suitable controller, capable of maintaining the required speed and with prescribed restoring capabilities after shocks is briefly described in the paper. Attached to the driving mass, a second mass, free to move in the direction orthogonal to the motion of the first mass, is subjected to a Coriolis force, proportional to the product of the first mass speed by z-axis rotational speed. The sensing of the Coriolis force and, in turn, of the z-axis rotational speed, is performed in closed loop fashion, with a 1-bit quantized actuation. The restoring force that brings the motion of the second mass to zero is equivalent to the output bit stream of a band-pass sigma-delta converter and contains the information of the Coriolis force. The design of this second control loop and a detailed analysis on the signal-to-noise ratio achievable with the proposed design is reported.
Observation of neodymium electroluminescence (1999)

Organic electroluminescence devices using a neodymium(III) complex as an emitting layer were fabricated. The cell structure of glass substrate/indium–tin–oxide/N,N′-diphenyl-N,N′-di(m-tolyl)-benzidine/tris(dibenzoylmethanato)(monobathophenanthroline)neodymium(III) complex/tris(8-quinolinolato)aluminum(III) complex/Mg:Ag was employed. Sharp near-infrared emission bands assigned to f–f transitions of neodymium ion were obtained at dc bias voltage of over 15 V.
Antimalarial pantothenamide metabolites target acetyl–coenzyme A biosynthesis in Plasmodium falciparum (2019)

Malaria eradication is critically dependent on new therapeutics that target resistant <i>Plasmodium</i> parasites and block transmission of the disease. Here, we report that pantothenamide bioisosteres were active against blood-stage <i>Plasmodium falciparum</i> parasites and also blocked transmission of sexual stages to the mosquito vector. These compounds were resistant to degradation by serum pantetheinases, showed favorable pharmacokinetic properties, and cleared parasites in a humanized mouse model of <i>P. falciparum</i> infection. Metabolomics revealed that coenzyme A biosynthetic enzymes converted pantothenamides into coenzyme A analogs that interfered with parasite acetyl-coenzyme A anabolism. Resistant parasites generated in vitro showed mutations in acetyl-coenzyme A synthetase and acyl-coenzyme A synthetase 11. Introduction and reversion of these mutations in <i>P. falciparum</i> using CRISPR-Cas9 gene editing confirmed the roles of these enzymes in the sensitivity of the malaria parasites to pantothenamides. These pantothenamide compounds with a new mode of action may have potential as drugs against malaria parasites.
Broadband optoelectronic integrated receiver front-ends comprising InP-based heterojunction bipolar transistors and base-collector photodiodes (1994)

Optoelectronic integrated circuits (OEICs) may be the implementation choice over hybrid receivers for long-wavelength photoreceiver front-ends required to operate at data rates ≥ 10 Gbit/s. The OEIC advantage is primarily due to the achievement of reduced parasitics associated with the node connecting the photodiode and the preamplifier circuit, thereby permit-ting wider-bandwidth operation. Other potential advantages are higher reliability and lower manufacturing costs. Previously, the performance advantage has been offset by the complexities associated with the simultaneous realization of high-quality optical and electronic devices, and, as a result, hybrid receivers have offered, to date, better performance than OEICs, particularly for &lt; 10-Gbit/s operation. However, promising results for OEIC receivers have been reported in recent years in a variety of technologies: p-i-n junction field-effect transistor (JFET),1 metal-semiconductor-metal (MSM) high-electron-mobility transistor (HEMT),2 p-i-n HEMT," and p-i-n hetero-junction bipolar transistor (HBT).4,5 In this paper we present results for broadband OEIC receivers based on InP-based HBT technology, which will be useful in applications requiring 20-Cbids operation and beyond.
Memory Characterization of the ECperf Benchmark (2003)

The quest for quantitative performance analysis in computer architecture research and design led to many research papers based on the commercially important DSS and OLTP database applications. Today’s middleware, and in particular application servers, are rapidly gaining popularity as a new workload for commercial multiprocessor servers. Therefore, it is important to expand architecture studies into this area. SPEC has recognized the importance of application servers and Java-Based middleware with its recent adoption of SPECjAppServer2001, formerly ECperf, as one of its benchmarks. In this paper, we present a detailed characterization of the memory system behavior of ECperf running on both commercial server hardware and in a simulated environment. We find that the working sets of ECperf fit in a reasonably sized L2 cache, but that the miss rate is very sensitive to associativity. Furthermore, many of the L2 misses in ECperf are satisfied by data from the cache of a neighboring processor. Based on these findings, we conclude that ECperf is an excellent candidate for shared-cache memory systems, even when the total cache size is limited.
Recommendation based on Emotional Preference (2020)

This paper describes an outline and a design of a recommender system that gives recommendations of contents based on the estimation of user's emotional preferences. Recommender systems are essential tools in the age of information overload, and they are helpful to increase comfortability and quality of life by filtering out annoying, unnecessary and troublesome information. The standard recommender system uses personal database, which stores the profile and preferences of a user. The key point of this study is a use of emotions in the personal preferences. Emotions are subjective quantities so that are difficult to deal with. This paper explains how our system identify emotions and how to deal with them in the recommender system. We also consider risk avoidance in information presentation of recommendations.
Synthesis of 5,5-Disubstituted Butenolides Based on a Pd-Catalyzed γ-Arylation Strategy (2009)

Methods for the construction of quaternary carbon centers are of great interest to synthetic chemists due to their presence in natural products. Development of the Pd-catalyzed arylation of butenolides with high selectivity for the γ-position allows for a facile construction of quaternary centers. The preparation of a wide variety of γ-aryl butenolides containing a number of functional groups is outlined. An application of this chemistry for a one-pot synthesis of a tricyclic tetrahydroisoquinolinone is demonstrated.
Is p75<sup>NGFR</sup> Involved in Developmental Neural Cell Death? (1994)

The tumor necrosis factor receptor superfamily includes twelve members, at least two of which – tumor necrosis factor receptor I and FAS/Apo-1 – induce cell death following ligand binding. This review summarizes data suggesting that two other members of the family – p75NGFR and CD40 – achieve a similar effect in the inverse fashion: they induce apoptosis constitutively when unbound by their respective ligands, with the induction of apoptosis being inhibited by the binding of their respective ligands. The potential roles that such receptors may play in development and pathological processes are discussed.
THE COARSE-GRAINED/FINE-GRAINEDLOGICINTERFACEINFPGASWITH EMBEDDED FLOATING-POINTARITHMETICUNITS (2008)

Thispaper examines theinterface between fine-grained and coarse-grained programmable logic inFPGAs.Specifically, itpresents anempirical study that covers thelocation, pin arrangement, andinterconnect between embedded floating point units (FPUs) andthefine-grained logic fabric inFPGAs.Theresults showthat (1)FPUsshould besquare, (2)FPUsshould bepositioned tightly nearthecenter ofthe FPGAand(3)that theFPUpins should bearranged onfour sides oftheFPU.
The First Structural Characterization of a Five Coordinate Aluminum Trichloride-Bidentate Tertiary Amine Adduct, Trichloro (1,4-dimethylpiperazine) aluminum (III) (1996)

Treatment of 1,4-dimethylpiperazine with AlCl3 affords the title compound, the X-ray crystal structure of which shows it to be a chelate complex with a trigonal bipyramidal aluminum center having one axial and two equatorial chloride ligands.
Optimization of gain bandwidth and gain ripple of a hybrid Raman/parametric amplifier for access network applications (2012)

We describe the mathematical model and present simulation results for the optimization of a hybrid Raman/optical parametric amplifier (HROPA), exhibiting a bandwidth of 170 nm and low ripple that covers the top half of the wavelength plan (e.g., 1441 to 1611 nm) of next generation coarse wavelength division multiplexed passive optical network systems. We show that a critical parameter in the proper amplifier parameter optimization is the inclusion of the fourth-order dispersion coefficient (β(4)). Omission of β(4) can lead to over-estimation or underestimation of the gain bandwidth, and hence its inclusion in the analysis of the HROPA is necessary.
Q-DSR protocol in vehicular ad-hoc networks (2015)

Multimedia streaming services in vehicular ad-hoc networks (VANETs) became a focus of many researchers. Achieving stable and high streaming rate under the high dynamic topology is considered a major challenge in such networks. Several approaches have been proposed to improve the existing routing protocols. However, some protocols ignore the QoS requirements needed for VANET safety and multimedia services whereas other protocols do not consider the high mobility of such networks while selecting the paths. In this paper, we improve the performance of the Dynamic Source Routing (DSR) protocol by enhancing the reliability of the network. This can be achieved by taking into account the QoS and the high speed constraints while selecting the paths. Thus, our solution is a new QoS-based DSR protocol that can increase both the stability and the reliability of the network. The simulation results show that the proposed protocol succeeds in improving the packet delivery ratio and reducing the probability of packet loss compared to the classical DSR protocol.
A versatile route to polythiophenes with functional pendant groups using alkyne chemistry (2016)

A new versatile polythiophene building block, 3-(3,4-ethylenedioxythiophene)prop-1-yne (pyEDOT) (<b>3</b>), is prepared from glycidol in four steps in 28% overall yield. pyEDOT features an ethynyl group on its ethylenedioxy bridge, allowing further functionalization by alkyne chemistry. Its usefulness is demonstrated by a series of functionalized polythiophene derivatives that were obtained by pre- and post-electropolymerization transformations, provided by the synthetic ease of the Sonogashira coupling and click chemistry.
Finding beam loss locations in a linac with oscillating dipole correctors (2019)

The paper proposes a method of finding the beam loss locations in a linac. If the beam is scraped at an aperture limitation, moving its centroid with two dipole correctors located upstream and oscillating in sync produces a line at the corresponding frequency in spectra of current-sensitive devices downstream of the loss point. The phase of this signal contains information about the location of the beam loss. Similar lines appear also in the position signals of Beam Position Monitors (BPMs). The phases of the BPM position lines change monotonically (within each 2π) along the linac and can be used a reference system. The phase of the loss signal compared with this reference system pinpoints the beam loss location, assuming that longitudinal coordinates of the BPMs are known. If the correctors deflection amplitudes and the phase offset between their waveforms are chosen optimally and well calibrated, the same measurement provides values of the β-function and the betatron phase advance at the BPM locations. Optics measurements of this type can be made parasitically, with negligible effect on the emittance, if a long measurement time is acceptable.