gebhart/patrepeval huggingface dataset:
Abstract 1887: Preclinical development of BB-1701, a HER2-tageting eribulin-containing ADC with potent bystander effect and ICD activity (2023)

Abstract Several HER2-targeting antibody-drug conjugates (ADC) have gained market approval for the treatment of HER2-expressing metastasis. However, these ADC drugs still face challenges of acquired resistance and/or severe adverse effects associate with their payload toxins. Eribulin, a market approval agent for the treatment of metastatic breast cancer and liposarcoma , is a new choice of ADC payload with distinct mechanism of action (MOA). Here we report preclinical studies of BB-1701, a novel HER2-tageting eribulin-containing ADC. BB-1701 exhibited potent and specific cytotoxicity activities to various types of cancer cells where HER2-exprssing levels vary in large ranges. BB-1701 induced tumor-growth suppression, even regression in in vivo models with a single dose of 1-5 mg/kg dosage. In comparison with other HER2-targeting ADCs with different toxin payloads (DM1, MMAE and Dxd), eribulin-containing ADC demonstrated higher potency to cancer cell lines with low HER2 expressing levels (with lower IC50). BB-1701 also showed effective tumor suppression in models insensitive to T-DM1 or T-Dxd. Mode of action studies revealed significant bystander cytotoxicity of BB-1701 to HER2-low cells when co-cultured with HER2-high cells. Additionally, BB-1701 treatment increased ATP releasing and Calreticulin expression, both were deemed immunogenic cell death (ICD) markers. Lastly, repeat dose pharmacokinetic and toxicology studies in nonhuman primates revealed favorable PK and safety profiles of BB-1701 in the clinical intend dosage route and schedule. In conclusion, these comprehensive preclinical data have strongly supported BB-1701 as a potent antitumor agent to cancers including HER2-low expressing and/or cancers insensitive to other HER2-targeting ADCs. A phase I clinical study of BB-1701 in those patients is ongoing. Citation Format: Yang Wang, Bing Xia, Lixia Cao, Jianfeng Yang, Cui Feng, Fangdun Jiang, Chen Li, Lixia Gu, Yifan Yang, Jing Tian, Cindy Cheng, Keiji Furuuchi, James Fulmer, Arielle Verdi, Katherine Rybinski, Allis Soto, Earl Albone, Toshimitsu Uenaka, Likun Gong, Tingting Liu, Qiuping Qin, Ziping Wei, Yuhong Zhou. Preclinical development of BB-1701, a HER2-tageting eribulin-containing ADC with potent bystander effect and ICD activity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1887.
Performance Evaluation of WDM Channel Transmission for Probabilistic Shaping With Partial Multilevel Coding (2021)

We propose partial multilevel coding (MLC) for optical communications with probabilistic shaping (PS), which improves the signal-to-noise ratio performance and makes information rates more adaptable, while reducing the power consumed by forward error correction. We designed simulation models of partial-MLC and bit-interleaved coded modulation (BICM) implementing the same low-density parity-check code to have almost the same transmission performance in an additive white Gaussian noise channel. The estimated power consumption of the partial-MLC model was about 38~39% lower than that of the BICM model. Next, we evaluated the effect of nonlinearity on fiber wavelength division multiplexing (WDM) channels in numerical simulations. The results showed that both models behaved similarly regardless of nonlinear noise, illustrating the usefulness of MLC with PS for optical transmissions on WDM channels.
Progress in crosswell induction imaging for EOR: field system design and field testing (1999)

At Lawrence Livermore National Laboratory (LLNL), we are continuing our effort to develop improved crosswell low-frequency electromagnetic imaging techniques, which are used to map in situ steamflood and waterflood movement during enhanced oil recovery (EOR) operations. Toward this effort, we procured two new borehole-logging field vehicles, and developed and integrated new crosswell electromagnetic transmitter and receiver data acquisition and control systems into these vehicles. We tested this new acquisition system by conducting a suite of background measurements and repeatability experiments at the Richmond Field Station in Richmond, California. Repeatability of a given scan in which the receiver was fixed and the transmitter position was varied over 60 m in 0.2-m increments resulted in amplitude differences of less than 0.6% and phase differences of less than 0.54 deg. Forward modeling produced a resistivity map fully consistent with well log data from the Richmond Field Station. In addition, modeling results suggest (1) that residual high-conductivity saltwater, injected in 1993 and pumped out in 1995, is present at the site and (2) that it has diffused outward from the original target strata. To develop crosswell electromagnetic imaging into a viable commercial product, our future research must be a two-fold approach: (1) improved quantification of system noise through experiments such as ferromagnetic core characterization as a function of temperature, and (2) development of procedures and codes to account for steel-cased hole scenarios.
Nitrogen Profile Study for SiON Gate Dielectrics of Advanced Dynamic Random Access Memory (2008)

Nitrogen profile variations were systematically studied for the plasma nitridation process of the dynamic random access memory (DRAM) gate dielectrics, using angle-resolved X-ray photoelectron spectroscopy (AR-XPS), and their influences to the boron blocking and the device performances including negative bias temperature instability (NBTI) were investigated. Nitrogen atoms incorporated are localized in the surface vicinity within 1.5 nm of the thickness and at the peak positions around 0.5 nm. The high pressure and high temperature conditions of plasma nitridation are preferred for improving the NBTI and the tool productivity. Post nitridation anneal stabilizes the nitrogen atoms incorporated, and improves the immunity against the boron penetration into the gate dielectrics. Both of re-oxidation and the out-diffusion of nitrogen atoms take place simultaneously near the surface during the queue time after the plasma nitridation. Microwave plasma with the radial line slot antenna (RLSA) is a successful SiON gate insulator formation technology in the manufacturing of DRAM as well as logic devices.
Viscosity and potentiometric measurements of poly(L‐histidyl‐L‐alanyl‐α‐L‐glutamic acid) and poly(L‐lysyl‐L‐alanyl‐α‐L‐glutamic acid) (1977)

Abstract Poly(His‐Ala‐Glu) and poly(Lys‐Ala‐Glu) were examined by viscosity and potentiometric titration. These measurements were interpreted in terms of the hydrodynamic size of the above sequential polypeptides. Effects of polymer, size and concentration, and solution‐salt concentration were demonstrated. Although the sequential polypeptides generally behave like polyampholytes, they do demonstrate some differences. These differences my be attributed to the ability of ionized side chains three residues apart to repel themselves, in the order His &lt; Glu &lt; Lys.
The Antibiotic Prophylaxis Guideline for Prosthetic Joints: Trying to Do the Right Thing (2013)

Lockhart, Peter B. DDS; Garvin, Kevin L. MD; Osmon, Douglas R. MD; Hewlett, Angela L. MD; Scuderi, Giles MD; Lewallen, David MD; Vail, Thomas MD Author Information
Rapid and Efficient Trifluoromethylation of Aromatic and Heteroaromatic Compounds Using Potassium Trifluoroacetate Enabled by a Flow System (2013)

Going to the source: The trifluoromethylation of aryl/heteroaryl iodides has been demonstrated using a flow system, thus enabling a rapid rate of reaction. A broad spectrum of trifluoromethylated compounds was prepared in good to excellent yields using CF3 CO2 K as the trifluoromethyl source. The process has the advantage of short reaction times and uses convenient [CF3 ] sources.
Physiopathological changes of ferritin mRNA density and distribution in hippocampal astrocytes in the mouse brain (2022)

Astrocytes are thought to play a crucial role in brain iron homeostasis. How they accomplish this regulation in vivo is unclear. In a recent transcriptomic analysis, we showed that polysomal Ftl1 and Fth1 mRNAs, encoding the ferritin light (Ftl) and heavy (Fth) chains that assemble into ferritin, a critical complex for iron storage and reduction, are enriched in perisynaptic astrocytic processes as compared to astrocytic soma. These data suggested that ferritin translation plays a specific role at the perisynaptic astrocytic interface and is tighly regulated by local translation. Here, we used our recently described AstroDot 3D in situ methodology to study the density and localization of ferritin mRNAs in astrocytes in the hippocampus in three different contexts in which local or systemic iron overload has been documented: aging, the hepcidin knock-out mouse model of hemochromatosis and the APP/PS1dE9 mouse model of Alzheimer's disease (AD). Our results showed that in wild type mice, Fth1 mRNA density was higher than Ftl1 and that both mRNAs were mostly distributed in astrocyte fine processes. Aging and absence of hepcidin caused an increased Fth1/Ftl1 ratio in astrocytes and in the case of aging, led to a redistribution of Fth1 mRNAs in astrocytic fine processes. In contrast, in AD mice, we observed a lower Fth1/Ftl1 ratio. Fth1 mRNAs became more somatic and Ftl1 mRNAs redistributed in large processes of astrocytes proximal to Amyloid beta (Aß) deposits. Hence, we propose that regulation of ferritin mRNA density and distribution in astrocytes contribute to iron homeostasis in physiology and pathophysiology.
Devices for silicon microphotonic interconnection: photonic crystals, waveguides and silicon optoelectronics (2003)

Silicon microphotonics is the optical equivalent of microelectronics for integrated circuits. Photonics enables interconnection that is not limited by transmission bandwidth. Photonic switching promises ultrafast routing and encoding of information for telecommunications and data transmission. The key implementation issue is the integration of photonic components with integrated circuit electronics. Silicon microphotonics utilizes silicon-based materials that are process compatible with standard integrated circuit fabrication methods.
Fluorescence confocal microimaging of the distal airways during bronchoscopy (2006)

International audience
Presenting: The Consultant to Counselors. (1974)

i he past decade has witnessed a shift time to pull together the information in the thinking about the role to be about the functioning of consultants played by school counselors. The to counselors and to develop a ra major change has been the addition of tionale for their functions, use, com the function of consultant to teachers petencies, and training, and others. This has been added to The major proponents of the con the earlier functions of counselor to sultant-to-counselor concept have been students and coordinator of activities Lister and the staff of the counselor
Quasi-normal mode theory applied to elliptic-filter metasurface design (2021)

We present universal analytical criteria for the quasi-normal modes (resonances) of lossless reciprocal 2-port systems to systematically design symmetric or “antimetric” scattering responses, emphasizing compact high-order standard filters. As an application, we design microwave metasurface bandpass or bandstop elliptic filters with various orders and bandwidths.
DOKUMA TEZGAHLARINDAN DENETLEYİCİ ALAN AĞI İLE VERİ TOPLAMA (2007)

Dokuma salonlarının verim analizini yapmak ve verimini arttırmak için her bir dokuma tezgahından tezgaha ait teknik veriler ve günlük dokuma verilerinin elde edilmesi ve bu verilerin analizlerinin yapılması gerekmektedir. Küçük ve orta ölçekli dokuma salonlarında tezgahlara ait teknik veriler genel olarak sorumlu personel tarafından tutulmaktadır. Verilerin belirli bir otomasyon çerçevesinde işlenmemesi dokuma salonlarının verimlilik analizlerini güçleştirmekte veya güvenilirliğini düşürebilmektedir. Bu makalede, orta ölçekli bir tekstil dokuma salonunda tezgahların verim analizini yapabilmek amacıyla geliştirilen ve uygulanan denetleyici alan ağını (DAA) kullanan bir veri toplama sistemi sunulmaktadır. Sistemde dokuma tezgahına ait teknik ve dokuma verileri tezgah üzerinde bulunan bağlantı noktalarından alınan veriler DAA üzerinden merkez bilgisayara iletilmekte ve merkez bilgisayarda işlenmektedir.
Nucleoside Tetra- and Pentaphosphates Prepared Using a Tetraphosphorylation Reagent Are Potent Inhibitors of Ribonuclease A (2019)

Adenosine and uridine 5'-tetra- and 5'-pentaphosphates were synthesized from an activated tetrametaphosphate ([PPN]<sub>2</sub>[P<sub>4</sub>O<sub>11</sub>], [PPN]<sub>2</sub>[<b>1</b>], PPN = bis(triphenylphosphine)iminium) and subsequently tested for inhibition of the enzymatic activity of ribonuclease A (RNase A). Reagent [PPN]<sub>2</sub>[<b>1</b>] reacts with unprotected uridine and adenosine in the presence of a base under anhydrous conditions to give nucleoside tetrametaphosphates. Ring opening of these intermediates with tetrabutylammonium hydroxide ([TBA][OH]) yields adenosine and uridine tetraphosphates (<b>p</b><sub>4</sub><b>A</b>, <b>p</b><sub>4</sub><b>U</b>) in 92% and 85% yields, respectively, from the starting nucleoside. Treatment of ([PPN]<sub>2</sub>[<b>1</b>]) with AMP or UMP yields nucleoside-monophosphate tetrametaphosphates (<b>cp</b><sub>4</sub><b>pA, cp</b><sub>4</sub><b>pU</b>) having limited aqueous stability. Ring opening of these ultraphosphates with [TBA][OH] yields <b>p</b><sub>5</sub><b>A</b> and <b>p</b><sub>5</sub><b>U</b> in 58% and 70% yield from AMP and UMP, respectively. We characterized inorganic and nucleoside-conjugated linear and cyclic oligophosphates as competitive inhibitors of RNase A. Increasing the chain length in both linear and cyclic inorganic oligophosphates resulted in improved binding affinity. Increasing the length of oligophosphates on the 5' position of adenosine beyond three had a deleterious effect on binding. Conversely, uridine nucleotides bearing 5' oligophosphates saw progressive increases in binding with chain length. We solved X-ray cocrystal structures of the highest affinity binders from several classes. The terminal phosphate of <b>p</b><sub>5</sub><b>A</b> binds in the P<sub>1</sub> enzymic subsite and forces the oligophosphate to adopt a convoluted conformation, while the oligophosphate of <b>p</b><sub>5</sub><b>U</b> binds in several extended conformations, targeting multiple cationic regions of the active-site cleft.
Self-focusing in CS_2 at 106 μm (1985)

We have measured the nonlinear refractive index, n(2), of CS(2) at 10.6 microm by observing the onset of whole-beam selffocusing. We find that n(2) is (2.2 +/- 0.7) x 10(-10) esu, which is over an order of magnitude larger than n(2) in the visible.
TGA1a, a tobacco DNA-binding protein, increases the rate of preinitiation complex formation in a plant in vitro transcription system [corrected] (1990)

We describe here a plant in vitro transcription system for class II promoters using wheat germ extract. In this system transcription is stimulated by TGA1a, a tobacco DNA-binding protein, and the stimulation is dependent on the presence of its cognate binding site upstream of the TATA box. Titration experiments showed that transcription initiation is more sensitive than transcription elongation to low concentrations of sarkosyl (N-lauroylsarcosine). At 0.07% sarkosyl, the formation of initiated complex is inhibited but transcription elongation is not. Under these conditions, events associated with a single round of transcription can be studied. We demonstrate that the time required for completing transcription of a 380-base-pair template is about 10 min. Addition of TGA1a increases the number of preinitiation complexes by approximately 3-fold with no significant effect on the frequency of transcription initiation from a single complex or on the rate of RNA elongation. We anticipate that this in vitro system will be valuable for the elucidation of mechanisms that regulate transcription in plants.
Steganalysis attacks on stego-images using stego-signatures and statistical image properties (2004)

This paper discusses a strategy for detecting hidden messages in stego-images in Internet traffic. The strategy adopts attacks that are based on both the signatures of the most popular steganographic techniques and some of the statistical parameters of the images being analyzed. A gradual approach for the attacks is applied since the speed with which detection is to be achieved is an important factor. An extensive set of images with different file format including JPEG, GIF and BMP, different cover and stego object sizes was processed and the results achieved indicate a high degree of success.
Optimal Baseline Prostate-Specific Antigen Level to Distinguish Risk of Prostate Cancer in Healthy Men Between 40 and 69 Years of Age (2011)

The present study evaluated optimal baseline prostate-specific antigen (PSA) level at different ages in order to determine the risk of developing prostate cancer (CaP). We analyzed 6,651 Korean men, aged 40-69 yr. The serum PSA levels for these men were measured at one institute from 2000 to 2004 and were determined to be between 0-4 ng/mL. Patients were divided into 4 groups of 25th-percentile intervals, based on initial PSA level. Of these, the group with an increased risk was selected, and the optimal value was determined by the maximal area under a receiver-operating characteristic curve within the selected group. The risk of CaP diagnosis was evaluated by Cox regression. The mean follow-up period was 8.3 yr. CaP was detected in 27 of the 6,651 subjects. CaP detection rate was increased according to age. The optimal PSA value to distinguish the risk of CaP was 2.0 ng/mL for 50- to 69-yr-olds. Patients with a baseline PSA level greater than the optimal value had a 27.78 fold increase in the prostate cancer risk. Baseline PSA values are useful for determining the risk of developing CaP in Korean men for 50- and 69-yr-old. We suggest that PSA testing intervals be modified based on their baseline PSA levels.
RATIONAL CONTROL OF ELECTRONIC STRUCTURE AND LATTICE ARCHITECTURE IN ELECTRICALLY CONDUCTING MOLECULAR/MACROMOLECULAR ASSEMBLIES. (1982)

This article discusses an approach to control molecular stacking interactions in low-dimensional mixed molecular assemblies by locking partially oxidized metallomacrocycles together in a face-to-face orientation. Thus, doping of the cofacially linked polymers M(Pc)O sub n (M = Si, Ge, Sn; Pc = phthalocyaninato) with halogen (I2, Br2) or quinone (e.g., DDQ, TCNQ) electron acceptors produces robust, electrically conductive polymers with a wide range of stoichiometries and properties. The new materials have been studied by a variety of physical methods including X-ray diffraction, resonance Raman and infrared spectroscopy, ESR, static magnetic susceptibility, variable-temperature four-probe d.c., electrical conductivity, and voltage-shorted compaction techniques. Evidence is presented that some of the macromolecules have metal-like conductivity in the stacking direction and that transport properties within the series can be readily manipulated by rational variation of lattice architecture (e.g., the identity of the metal, M) and acceptor characteristics. Insight into those acceptor properties which stabilize the mixed valent state is provided. (Author)
Toxicology Study of Intra-Cisterna Magna Adeno-Associated Virus 9 Expressing Iduronate-2-Sulfatase in Rhesus Macaques (2018)

Hunter syndrome is an X-linked recessive disease caused by deficiency of the lysosomal enzyme iduronate-2-sulfatase. The severe form of this progressive, systemic, and neurodegenerative disease results in loss of cognitive skills and early death. Several clinical trials are evaluating adeno-associated virus 9 for the treatment of neurodegenerative diseases using systemic or intrathecal lumbar administration. In large animals, administration via suboccipital puncture gives better brain transduction than lumbar administration. Here, we conducted a good laboratory practice-compliant investigational new drug-enabling study to determine the safety of suboccipital adeno-associated virus 9 gene transfer of human iduronate-2-sulfatase into nonhuman primates. Thirteen rhesus macaques received vehicle or one of two doses of vector with or without immunosuppression. We assessed in-life safety and immune responses. Animals were euthanized 90 days post-administration and sampled for histopathology and biodistribution. The procedure was well tolerated in all animals. Minimal mononuclear cerebrospinal fluid pleocytosis occurred in some animals. Asymptomatic minimal-to-moderate toxicity to some dorsal root ganglia sensory neurons and their associated axons occurred in all vector-treated animals. This study supports the clinical development of suboccipital adeno-associated virus 9 delivery for severe Hunter syndrome and highlights a potential toxicity that warrants monitoring in first-in-human studies.
6.1 A 100Gb/s 1.1pJ/b PAM-4 RX with Dual-Mode 1-Tap PAM-4 / 3-Tap NRZ Speculative DFE in 14nm CMOS FinFET (2019)

The growing demand for higher data rates in wireline communications has led to emerging standards in the 100Gb/s+ range using PAM-4 signaling. ADC-based receivers have demonstrated robust operation over channels with high losses (>20dB) [1], but their power consumption (>500mW/lane excluding DSP) is prohibitive for applications requiring large port counts in short-reach chip-to-chip and chip-to-module links (such as OIF-CEI-112G-VSR/XSR/USR). This work demonstrates a dual PAM-4/NRZ RX implemented in 14nm FinFET and measured up to 100Gb/s in PAM-4 mode achieving pre-FEC BER<;10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> across a 19.2dB-loss channel with low power. To achieve low BER with >16dB loss channel the RX uses a CTLE combined with a 1-tap speculative DFE. To minimize power consumption, the number of slicing levels to resolve the 1-tap PAM-4 DFE speculation is reduced from 12 to 8 by shaping the channel to a 1+0.5D response (h0+0.5*h0) with CTLE and TXFFE. With a 1+0.5D channel, 4 out of 12 speculative decisions are overlapped. Moreover, comparators used for DFE speculation can be shared for phase detection in a baud-rate CDR scheme, extending the concept proposed in [2] to PAM-4. In NRZ mode, the RX features a fully speculative 3-tap DFE to equalize high loss channels (>35dB) at 56Gb/s. The RX incorporates the following key advances: (1) a trans-admittance transimpedance (TAS-TIS) CTLE circuit resulting in a low-power and compact analog-front-end (AFE), (2) a 1-tap PAM-4 speculative DFE based on a 1+0.5D response, and (3) a CMOS quadrature-DLL (QDLL) generating quadrature clock phases resulting in a low jitter/power clock path.
Two-photon photocurrent in InGaN/GaN nanowire intermediate band solar cells (2020)

Abstract Intermediate band solar cells hold the promise of ultrahigh power conversion efficiencies using a single semiconductor junction. Many current implementations use materials with bandgaps too small to achieve maximum efficiency or use cost-prohibitive substrates. Here we demonstrate a material system for intermediate band solar cells using InGaN/GaN quantum-dot-in-nanowire heterostructures grown directly on silicon to provide a lower cost, large-bandgap intermediate band solar cell platform. We demonstrate sequential two-photon current generation with sub-bandgap photons, the hallmark of intermediate band solar cell operation, through vertically stacked quantum dots in the nanowires. Near-infrared light biasing with an 850 nm laser intensity up to 200 W/cm 2 increases the photocurrent above and below the bandgap by up to 19% at 78 K, and 44% at room temperature. The nanostructured III-nitride strategy provides a route towards realistic room temperature intermediate band solar cells while leveraging the cost benefits of silicon substrates.