gebhart/patrepeval huggingface dataset:
Visualization of radionuclide imaging and activation recovery intervals on the epicardial surface (2002)

Greater knowledge of the factors influencing ventricular arrhythmias will aid in the identification people who are at risk for cardiac sudden death. The authors investigated whether regional heterogeneity of sympathetic innervation results in heterogeneous distributions of repolarization responses and whether this heterogeneity is a substrate for arrhythmias. The authors found the distribution of myocardial sympathetic nerve endings in autoradiographic images, and they measured repolarization changes by determining activation recovery intervals (ARI) from unipolar electrograms on the surface of the heart. An epicardial surface was extracted from autoradiographic images to display the distribution of innervation, and the activation recovery intervals were mapped onto the epicardial surface.
Spherical Vector Wave Expansion of Gaussian Electromagnetic Fields for Antenna-Channel Interaction Analysis (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> In this paper, we introduce an approach to analyze the interaction between antennas and the propagation channel. We study both the antennas and the propagation channel by means of the spherical vector wave mode expansion of the electromagnetic field. Then we use the expansion coefficients to study some properties of general antennas in those fields by means of the antenna scattering matrix. The focus is on the spatio-polar characterization of antennas, channels and their interactions. We provide closed form expressions for the covariance of the field multimodes as function of the power angle spectrum (PAS) and the channel cross-polarization ratio (XPR). A new interpretation of the mean effective gains (MEG) of antennas is also provided. The maximum MEG is obtained by conjugate mode matching between the antennas and the channel; we also prove the (intuitive) results that the optimum decorrelation of the antenna signals is obtained by the excitation of orthogonal spherical vector modes. </para>
Carbonation of γ-Ca<sub>2</sub>SiO<sub>4</sub> and the Mechanism of Vaterite Formation (2010)

The carbonation of γ-Ca2SiO4 (γ-C2S) and mechanism of vaterite formation have been investigated by evaluating the crystal structures of both γ-C2S and vaterite. The samples used were autoclaved calcium silicate hydrate hardening bodies prepared from Ordinary Portland Cement (OPC), γ-C2S and α-quartz and then subjected to accelerated carbonation. The ratio of OPC to γ-C2S was varied. Ca2+ in both γ-C2S and vaterite was found to be coordinated to six O2-. In addition, both γ-C2S and vaterite have similar atomic arrangements of O2- and Ca2+ and Ca-O bond distances. Therefore, it is proposed that vaterite mainly forms from γ-C2S via a topotactic reaction during accelerated carbonation.
Optical Receiver Development for High Speed Free-Space Optical Interconnects (2001)

To this end, we have carried out a comprehensive detailed modeling of electronic post-optical detection amplifiers based on CMOS technology. We have optimized such receivers for FSOI applications. We have validated our models by experimental verification using MOSIS foundry. We have demonstrated the successful operation of CMOS trans-impedance amplifier based receivers fabricated in 0.35 micron process with optimized performance for FSOI links performance.
Gold-Catalyzed Cascade Annulations of 2-(Ynol)aryl Aldehydes: Facile Synthesis of Benzochromanes and Benzobicyclo[n.3.1]acetals (2010)

Gold-catalyzed reactions of 2-(ynol)aryl aldehydes were investigated. Benzochromanes were obtained from the reaction when AuCl(3) was employed as the catalyst, whereas benzobicyclo[n.3.1]acetals were produced when triazole-gold was employed as the catalyst. Plausible mechanisms are discussed.
Differentially private and strategy-proof spectrum auction with approximate revenue maximization (2015)

The rapid growth of wireless mobile users and applications has led to high demand of spectrum. Auction is a powerful tool to improve the utilization of spectrum resource, and many auction mechanisms have been proposed thus far. However, none of them has considered both the privacy of bidders and the revenue gain of the auctioneer together. In this paper, we study the design of privacy-preserving auction mechanisms. We first propose a differentially private auction mechanism which can achieve strategy-proofness and a near optimal expected revenue based on the concept of virtual valuation. Assuming the knowledge of the bidders' valuation distributions, the near optimal differentially private and strategy-proof auction mechanism uses the generalized Vickrey-Clarke-Groves auction payment scheme to achieve high revenue with a high probability. To tackle its high computational complexity, we also propose an approximate differentially PrivAte, Strategy-proof, and polynomially tractable Spectrum (PASS) auction mechanism that can achieve a suboptimal revenue. PASS uses a monotone allocation algorithm and the critical payment scheme to achieve strategy-proofness. We also evaluate PASS extensively via simulation, showing that it can generate more revenue than existing mechanisms in the spectrum auction markets.
A Risk Variant in an miR-125b Binding Site in BMPR1B Is Associated with Breast Cancer Pathogenesis (2009)

MicroRNAs regulate diverse cellular processes and play an integral role in cancer pathogenesis. Genomic variation within miRNA target sites may therefore be important sources for genetic differences in cancer risk. To investigate this possibility, we mapped HapMap single nucleotide polymorphisms (SNP) to putative miRNA recognition sites within genes dysregulated in estrogen receptor-stratified breast tumors and used local linkage disequilibrium patterns to identify high-ranking SNPs in the Cancer Genetic Markers of Susceptibility (CGEMS) breast cancer genome-wide association study for further testing. Two SNPs, rs1970801 and rs11097457, scoring in the top 100 from the CGEMS study, were in strong linkage disequilibrium with rs1434536, an SNP that resides within a miR-125b target site in the 3' untranslated region of the bone morphogenic receptor type 1B (BMPR1B) gene encoding a transmembrane serine/threonine kinase. We validated the CGEMS association findings for rs1970801 in an independent cohort of admixture-corrected cases identified from families with multiple case histories. Subsequent association testing of rs1434536 for these cases and CGEMS controls with imputed genotypes supported the association. Furthermore, luciferase reporter assays and overexpression of miR-125b-mimics combined with quantitative reverse transcription-PCR showed that BMPR1B transcript is a direct target of miR-125b and that miR-125b differentially regulates the C and T alleles of rs1434536. These results suggest that allele-specific regulation of BMPR1B by miR-125b explains the observed disease risk. Our approach is general and can help identify and explain the mechanisms behind disease association for alleles that affect miRNA regulation.
Supplementary Data from <i>In vivo</i> Evaluation of Mucoadhesive Nanoparticulate Docetaxel for Intravesical Treatment of Non–Muscle-Invasive Bladder Cancer (2023)

&lt;p&gt;Supplementary Figures S1-S2; Supplementary Table S1.&lt;/p&gt;
Crystallographic studies of DNA minor groove binding drugs (2011)

to discover CARM1 specific inhibitors and their binding mode. Our last results concerning the development of news selective inhibitors of PRMTs will be also presented.
Data not shown from A First-in-Human Phase I Study of INVAC-1, an Optimized Human Telomerase DNA Vaccine in Patients with Advanced Solid Tumors (2023)

&lt;p&gt;This file compiles all the results identified as "data not shown" in the manuscript&lt;/p&gt;
On the performance of a scalable single-tier position based routing protocol for mobile ad-hoc wireless networks (2002)

This paper deals with the performance evaluation of a scalable single-tier routing protocol designed for operation in mobile ad hoc networking environments. The protocol under consideration is based on the superposition of link-state and position-based routing, and it employs a simplified way of localizing routing overhead, without having to resort to complex, multiple-tier routing organization schemes. Specifically we study the protocol's scalability measured by the routing overhead, by calculating the average number of routing packets per node, as a function of the network size. The obtained results demonstrate that the average number of routing packets transmitted by a node is practically insensitive to the network size. This clearly indicates that our protocol possesses the scalability property which is very critical in mobile ad hoc networking environments, without having to resort to complicated and vulnerable hierarchical approaches. Moreover we compare the performance of our protocol with a non-realistic "ideal routing protocol" where packets are routed assuming continuous and accurate knowledge of the exact node position. Specifically we study the "route distortion" introduced by our protocol due to inaccuracies in the positions of other hosts known by the local host, and compare the number of hops needed to route data under our approach against the corresponding results obtained for the "ideal routing". The results indicate that for various mobility scenarios our protocol has nearly optimum data routing characteristics. Finally we discuss various design parameters related to the protocol's operation and we investigate their impact on the protocol's performance and effectiveness.
The Antigen Processing and Presentation Machinery in Lymphatic Endothelial Cells (2019)

Until a few years ago, lymphatic vessels and lymphatic endothelial cells (LEC) were viewed as part of a passive conduit for lymph and immune cells to reach lymph nodes (LN). However, recent work has shown that LEC are active immunological players whose interaction with dendritic cells and T cells is of important immunomodulatory relevance. While the immunological interaction between LEC and other immune cells has taken a center stage, molecular analysis of LEC antigen processing and presentation machinery is still lagging. Herein we review the current knowledge of LEC MHC I and MHC II antigen processing and presentation pathways, Including the role of LEC in antigen phagocytosis, classical, and non-classical MHC II presentation, proteasome processing and MHC I presentation, and cross-presentation. The ultimate goal is to provide an overview of the LEC antigen processing and presentation machinery that constitutes the molecular basis for their role in MHC I and MHC II-restricted immune responses.
Discharge Properties and Emitted Electromagnetic Wave Spectrum in Low Vacuum Region of Vacuum Interrupter (2005)

Study on reliability of vacuum interrupter (VI) such as detection method of the slow leak has been extensively carried out, while study on discharge properties in low vacuum of VI is still insufficient. In this report, we experimentally investigated discharge properties inside VI under closed contact and open contact conditions of main contactors in low vacuum of VI to simulate vacuum leakage. We also measured current waveforms and spectrum of electromagnetic wave (EMW) emitted by discharges in VI. Furthermore, we discussed the relationship between partial discharge against the product of pressure and gap spacing, and compared the results with the Paschen's curve of air. We also discussed flowing path of the discharge current in an experimental circuit including VI.
Modular synthetic design enables precise control of shape and doping in colloidal zinc oxide nanorods (2015)

Highly tunable shapes and sizes of colloidal zinc oxide nanorods are achieved through a piecewise, multiple injection synthetic approach.
Asymmetric Nazarov Cyclizations Catalyzed by Chiral‐at‐Metal Complexes (2018)

Abstract The application of Lewis acidic chiral‐at‐metal complexes of iridium(III) and rhodium(III) as catalysts for the asymmetric polarized Nazarov cyclization of dihydropyran‐ and indole‐functionalized α‐unsaturated β‐ketoesters is reported (overall 24 examples). For both substrate classes, catalyst loadings of 2 mol% were found to be sufficient for achieving high yields and high stereoselectivities. The cyclized dihydropyran products were isolated in 85–98% yield, with 89%–&gt;99% ee, and trans / cis ratios of 15:1–50:1 (9 examples). The cyclized indole products were typically isolated in more than 70% yield and in up to 93% yield, typically with more than 90% ee and in up to 97% ee, and trans / cis ratios of 12:1–28:1 (15 examples). magnified image
In-Cylinder Measurements of Wall Layer Hydrocarbons in a Spark Ignited Engine (1983)

Abstract The hydrocarbon emissions process for the conventional, spark ignited, IC engine has been studied experimentally using a rapid acting gas sampling valve mounted in the combustion chamber wall. The sampling valve was electrohydraulically actuated. Design of the valve specifically allowed sampling in the vicinity of the wall quench layer with minimum leakage and crevice contributions to the measured hydrocarbon concentrations. Experimental results presented give substantial evidence that hydrocarbons remaining in a wall quench layer are not a major source of exhaust hydrocarbon emissions. Measurements of species concentrations as a function of time in the cycle and sample flow rate indicate that after flame arrival and quenching at the cold walls, hydrocarbons in the quench layer are rapidly and extensively oxidized within 2 msec. By use of an analytical model for the gas flow profile into the sampling valve, conservative upper limit calculations have been made of the quench layer contribution to the exhaust hydrocarbons for a number of engine operating conditions. These upper limit estimates show that quench layer hydrocarbons contribute no more than 3 to 12% to the hydrocarbons observed in the exhaust gases, depending upon the engine operating conditions. Hydrocarbons from other sources such as ringcrevice storage, and absorption-desorption of fuel from oil layers and surface deposits appear to be more important. Finally, evidence has been obtained for incomplete combustion of hydrocarbons in the bulk gas under homogeneous fuel-rich conditions.
The isolation, partial peptide sequence, and cDNA sequence of aromatic L-amino acid decarboxylase from bovine adrenal medulla / (1990)

antibody screen .......
On Dynamic Link Inference in Heterogeneous Networks (2012)

Network and linked data have become quite prevalent in recent years because of the ubiquity of the web and social media applications, which are inherently network oriented. Such networks are massive, dynamic, contain a lot of content, and may evolve over time in terms of the underlying structure. In this paper, we will study the problem of dynamic link inference in temporal and heterogeneous information networks. The problem of dynamic link inference is extremely challenging in massive and heterogeneous information network because of the challenges associated with the dynamic nature of the network, and the different types of nodes and attributes in it. Both the topology and type information need to be used effectively for the link inference process. We propose an effective two-level scheme which makes efficient macro- and micro-decisions for combining structure and content in a dynamic and time-sensitive way. The time-sensitive nature of the links is leveraged in order to perform effective link prediction. We illustrate the effectiveness of our technique over a number of real data sets.
Targeting Selective Activation of M1 for the Treatment of Alzheimer’s Disease: Further Chemical Optimization and Pharmacological Characterization of the M1 Positive Allosteric Modulator ML169 (2012)

The M(1) muscarinic acetylcholine receptor is thought to play an important role in memory and cognition, making it a potential target for the treatment of Alzheimer's disease (AD) and schizophrenia. Moreover, M(1) interacts with BACE1 and regulates its proteosomal degradation, suggesting selective M(1) activation could afford both palliative cognitive benefit as well as disease modification in AD. A key challenge in targeting the muscarinic acetylcholine receptors is achieving mAChR subtype selectivity. Our lab has previously reported the M(1) selective positive allosteric modulator ML169. Herein we describe our efforts to further optimize this lead compound by preparing analogue libraries and probing novel scaffolds. We were able to identify several analogues that possessed submicromolar potency, with our best example displaying an EC(50) of 310 nM. The new compounds maintained complete selectivity for the M(1) receptor over the other subtypes (M(2)-M(5)), displayed improved DMPK profiles, and potentiated the carbachol (CCh)-induced excitation in striatal MSNs. Selected analogues were able to potentiate CCh-mediated nonamyloidogenic APPsα release, further strengthening the concept that M(1) PAMs may afford a disease-modifying role in the treatment of AD.
Enantiospecific total synthesis of the protein phosphatase inhibitor motuporin. (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnantiospecific total synthesis of the protein phosphatase inhibitor motuporin.Robert J. Valentekovich and Stuart L. SchreiberCite this: J. Am. Chem. Soc. 1995, 117, 35, 9069–9070Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/ja00140a025https://doi.org/10.1021/ja00140a025research-articleACS PublicationsRequest reuse permissionsArticle Views658Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Tunable liquid crystal lens for a holographic projection system (2013)

The tunable liquid crystal (LC) lens designed for a holographic projection system is demonstrated. By using a single patterned electrode LC lens, a solid lens and an encoded Fresnel lens on the LCoS panel, we can maintain the image size of the holographic projector with different wavelengths (&lambda;674nm, 532nm and 445nm) . The zoom ratio of the holographic projection system depends on the lens power of the solid lens and the tunable lens power of the LC lens. The optical zoom function can help to solve the image size mismatching problem of the holographic projection system.
Case 1-1988 (1988)

Case Records of the Massachusetts General Hospital from The New England Journal of Medicine — Case 1-1988 — Fever and Renal Dysfunction in a 22-Year-Old Diabetic Woman after Renal and Pancreatic Transplantation
Perseverance’s Scanning Habitable Environments with Raman and Luminescence for Organics and Chemicals (SHERLOC) Investigation (2021)

Abstract The Scanning Habitable Environments with Raman and Luminescence for Organics and Chemicals (SHERLOC) is a robotic arm-mounted instrument on NASA’s Perseverance rover. SHERLOC has two primary boresights. The Spectroscopy boresight generates spatially resolved chemical maps using fluorescence and Raman spectroscopy coupled to microscopic images (10.1 μm/pixel). The second boresight is a Wide Angle Topographic Sensor for Operations and eNgineering (WATSON); a copy of the Mars Science Laboratory (MSL) Mars Hand Lens Imager (MAHLI) that obtains color images from microscopic scales (∼13 μm/pixel) to infinity. SHERLOC Spectroscopy focuses a 40 μs pulsed deep UV neon-copper laser (248.6 nm), to a ∼100 μm spot on a target at a working distance of ∼48 mm. Fluorescence emissions from organics, and Raman scattered photons from organics and minerals, are spectrally resolved with a single diffractive grating spectrograph with a spectral range of 250 to ∼370 nm. Because the fluorescence and Raman regions are naturally separated with deep UV excitation (&lt;250 nm), the Raman region ∼ 800 – 4000 cm −1 (250 to 273 nm) and the fluorescence region (274 to ∼370 nm) are acquired simultaneously without time gating or additional mechanisms. SHERLOC science begins by using an Autofocus Context Imager (ACI) to obtain target focus and acquire 10.1 μm/pixel greyscale images. Chemical maps of organic and mineral signatures are acquired by the orchestration of an internal scanning mirror that moves the focused laser spot across discrete points on the target surface where spectra are captured on the spectrometer detector. ACI images and chemical maps (&lt; 100 μm/mapping pixel) will enable the first Mars in situ view of the spatial distribution and interaction between organics, minerals, and chemicals important to the assessment of potential biogenicity (containing CHNOPS). Single robotic arm placement chemical maps can cover areas up to 7x7 mm in area and, with the &lt; 10 min acquisition time per map, larger mosaics are possible with arm movements. This microscopic view of the organic geochemistry of a target at the Perseverance field site, when combined with the other instruments, such as Mastcam-Z, PIXL, and SuperCam, will enable unprecedented analysis of geological materials for both scientific research and determination of which samples to collect and cache for Mars sample return.