gebhart/patrepeval huggingface dataset:
Channel integrated optoelectronic tweezer chip for microfluidic particle manipulation (2020)

Abstract Light patterned electrical fields have been widely used for the manipulation of microparticles, from cells to microscopic electronic components. In this work, we explore a novel electromechanical phenomenon for particle focusing and sorting where the electrical field patterns are shaped by a combination of the light patterned photoconductor and the channel geometry. This effect results from the combination of particle polarisation described by the Clausius–Mossotti relation and the engineering of large electric gradients produced by choosing the channels height to suit the size of the particles being manipulated. The matched geometry increases the distortion of the field created by a combination of the illuminated photoconductor and the particles themselves and hence the non-uniformity of the field they experience. We demonstrate a new channel integration strategy which allows the creation of precisely defined channel structures in the OET device. By defining channels in photoresist sandwiched between upper and lower ITO coated glass substrates we produce robust channels of well controlled height tailored to the particle. Uniquely, the top substrate is attached before photolithographically defining the channels. We demonstrate versatile control using this effect with dynamically reconfigurable light patterns allowing the retention against flow, focusing and sorting of micro particles within the channels. Contrary to traditional designs, this channel integrated device allows patterned micro channels to be used in conjunction with conductive top and bottom electrodes producing optimal conditions for the dielectrophoretic manipulation as demonstrated by the rapid flow (up to 5 mm s −1 ) in which the particles can be focused.
Platform for the generation of oral vaccines based on protozoan surface proteins. (2019)

The international spread of infectious diseases is a global problem of health security. Vaccination is one of the most successful and profitable health interventions. Oral immunization has significant advantages over the widely used parental vaccines. Intestinal and free-living protozoa express on their surface a dense layer of proteins that protect them from hostile environmental conditions. The use of variable surface proteins (VSPs), such as those of the intestinal protozoan Giardia lamblia, is a feasible mechanism for the generation of oral vaccines, since they are highly immunogenic as well as resistant to changes in pH and proteases. In a recently published article, we showed that these properties of VSPs can be exploited to protect and enhance the immunogenicity of vaccine antigens, thus enabling their oral administration. We recently generated an oral vaccine against influenza virus composed of virus-like particles (VLPs) containing VSPs of G. lamblia and the HA antigen (viral hemagglutinin) in its envelope. When administered orally to mice, these coated particles elicit HA-specific humoral (systemic and local) and cellular responses, without the need of any additional adjuvant. Treated mice are protected against viral challenge as well as against the development of tumors expressing the HA vaccine antigen.
7.1: Invited Paper: True 3D Display Technology (2005)

Abstract Conventional stereoscopic displays unnaturally require keeping eye accommodation fixed at one focal distance while dynamically varying vergence. This forced decoupling of reflexively linked processes fatigues eyes. Our multifocal True 3D displays generate accommodation cues that match vergence and stereoscopic retinal disparity demands, better mimicking natural vision and minimizing eye fatigue.
Evaluation of Rate-Based, Force-Reflecting Teleoperation in Free Motion and Contact (2000)

This research focuses on improved control for force-reflecting teleoperation systems in free motion and contact tasks. Specifically, the Naturally Transitioning Rate-to-Force Controller (NTRFC) is implemented in an Air Force experimental force-reflecting teleoperation system to achieve a unified controller with no mode switches from free motion to contact, and to reduce the wrench exerted on the environment by the slave manipulator during remote teleoperation tasks. In an effectiveness evaluation experiment, the experimental hypothesis is validated: the NTRFC with force reflection performs the best amongst four teleoperation control modes with respect to minimal wrench exertion on the environment. A negligible difference was found in total task-completion times amongst the four modes. The NTRFC with force reflection has the potential to improve task performance in remote, hazardous, teleoperation tasks in which minimal exerted wrench is desirable.
A History of Papermaking Around Niagara Falls: Harnessing the Power of the Falls (2023)

Paper production around the niagara river region began in the mid-1800s. Mills were situated on various local canals whose waterpower (hydraulic) was needed to grind and process the rags into paper. The regions around Niagara Falls were prime locations to set up these mills.
Dopant-Segregation Technique for Leakage Reduction and Performance Improvement in Trigate Transistors Without Raised Source/Drain Epitaxy (2014)

A dopant-segregation technique for junction engineering has been demonstrated on trigate transistors using a process flow that does not include raised source/drain epitaxy. It is shown that the dopant-segregation technique reduces the off-state leakage current and improves the on-state performance for NFET devices when compared with control devices built using conventional junction engineering. The dopant-segregation process has no observable impact on PFET device performance.
Design and Comparison of Permanent Magnet Self-Bearing Linear-Rotary Actuators (2019)

Linear-rotary actuators (LiRAs) are electric machines that can perform linear and rotary movements. They are used in many different applications, for example, for pick-and-place robots, in packaging or sorting lines, or as gearbox actuators. A linear-rotary movement can be obtained with various combinations of linear and rotary machines, whereas depending on the specifications of the underlying application the most suitable actuator arrangement has to be identified. In order to simplify the selection of the appropriate actuator configuration, this paper first gives an overview of possible realization concepts of linear-rotary actuators, which are also suitable to implement magnetic bearings (MB). Afterwards, fundamental scaling laws concerning achievable axial forces and torques of linear and rotary machines with interior and exterior rotor arrangement are derived, enabling a qualitative comparison in order to figure out the most suitable actuator concept. In this context, it is important that the derivation also considers the machine-internal heat flow and the heat dissipation to the ambient, which finally leads to a maximum current density depending on the selected topology. All findings are verified by finite element method simulations. In order to show the applicability of the derived scaling laws, a design example is discussed.
Efficacy of Intraoperative Intervention Following Transcranial Motor-evoked Potentials Alert During Posterior Decompression and Fusion Surgery for Thoracic Ossification of the Posterior Longitudinal Ligament (2020)

These results show the efficacy of intraoperative intervention following a Tc-MEP alert for prevention of neurological deficit postoperatively.Level of Evidence: 2.
The 8.6 inch-diagonal TFT-LCDs of symmetric sub-dot design (2002)

TFT-LCDs (thin-film transistor liquid-crystal displays) of symmetric subdot design that are 8.6 in measured diagonally have been developed. Each dot is divided into two subdots. These two subdots are symmetrical with respect to a source-busline. This configuration cancels the DC offset difference which is induced by the alignment tolerance and is especially effective for large-size TFT-LCDs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Functional Coupling of a Nematode Chemoreceptor to the Yeast Pheromone Response Pathway (2014)

Sequencing of the Caenorhabditis elegans genome revealed sequences encoding more than 1,000 G-protein coupled receptors, hundreds of which may respond to volatile organic ligands. To understand how the worm's simple olfactory system can sense its chemical environment there is a need to characterise a representative selection of these receptors but only very few receptors have been linked to a specific volatile ligand. We therefore set out to design a yeast expression system for assigning ligands to nematode chemoreceptors. We showed that while a model receptor ODR-10 binds to C. elegans Gα subunits ODR-3 and GPA-3 it cannot bind to yeast Gα. However, chimaeras between the nematode and yeast Gα subunits bound to both ODR-10 and the yeast Gβγ subunits. FIG2 was shown to be a superior MAP-dependent promoter for reporter expression. We replaced the endogenous Gα subunit (GPA1) of the Saccharomyces cerevisiae (ste2Δ sst2Δ far1Δ) triple mutant ("Cyb") with a Gpa1/ODR-3 chimaera and introduced ODR-10 as a model nematode GPCR. This strain showed concentration-dependent activation of the yeast MAP kinase pathway in the presence of diacetyl, the first time that the native form of a nematode chemoreceptor has been functionally expressed in yeast. This is an important step towards en masse de-orphaning of C. elegans chemoreceptors.
Inhibition of eukaryotic translation elongation by the antitumor natural product Mycalamide B (2011)

Mycalamide B (MycB) is a marine sponge-derived natural product with potent antitumor activity. Although it has been shown to inhibit protein synthesis, the molecular mechanism of action by MycB remains incompletely understood. We verified the inhibition of translation elongation by in vitro HCV IRES dual luciferase assays, ribosome assembly, and in vivo [(35)S]methinione labeling experiments. Similar to cycloheximide (CHX), MycB inhibits translation elongation through blockade of eEF2-mediated translocation without affecting the eEF1A-mediated loading of tRNA onto the ribosome, AUG recognition, or dipeptide synthesis. Using chemical footprinting, we identified the MycB binding site proximal to the C3993 28S rRNA residue on the large ribosomal subunit. However, there are also subtle, but significant differences in the detailed mechanisms of action of MycB and CHX. First, MycB arrests the ribosome on the mRNA one codon ahead of CHX. Second, MycB specifically blocked tRNA binding to the E-site of the large ribosomal subunit. Moreover, they display different polysome profiles in vivo. Together, these observations shed new light on the mechanism of inhibition of translation elongation by MycB.
[Clinical guidelines for diagnosis, treatment and monitoring of patients with non-invasive breast cancer]. (2013)

Breast cancer is the most common malignancy in women. Early diagnosis and more effective treatment of invasive breast cancer resulted in significant mortality reduction, improvement of survival and the quality of life of the patients. The management od non-invasive breast cancer, on the contrary, is still controversial and the problem of overdiagnosis and overtreatment of patients come to evidence. In the following text a multidisciplinary team of experts brings the first consensus guidelines aimed to standardize and optimize the criteria and management in diagnosis, treatment and monitoring of non-invasive breast cancer patients in the Republic of Croatia.
Creation of a protective pulmonary bioshield against inhaled organophosphates using an aerosolized bioscavenger (2016)

In addition to the global use of organophosphate (OP) pesticides for agriculture, OP nerve agents and pesticides have been employed on battlefields and by terrorists (e.g., a recent sarin attack in Syria). These occurrences highlight the need for an effective countermeasure against OP exposure. Human butyrylcholinesterase (HuBChE) is a leading candidate, but injection of the high doses required for protection present pharmacokinetic challenges. An aerosolized recombinant form (aer-rHuBChE) that can neutralize inhaled OPs at the portal of entry has been assessed for its efficacy in protecting macaques against respiratory toxicity following inhalation exposure to the pesticide paraoxon (aer-Px). While protection in macaques has been demonstrated using the MicroSprayer® delivery device, administration to humans will likely employ a vibrating mesh nebulizer (VMN). Compared to the 50-70% lung deposition achieved in adult humans with a VMN, deposition in macaques is <5%, an initial major obstacle to demonstrating protection. Such problems have been partly overcome by using a more efficient modified VMN and proportionally higher doses, which together generate an effective rHuBChE pulmonary bioshield and protect against high levels of inhaled Px.
Wireless system beyond 3G: acquisition specifications and solutions (2006)

info:eu-repo/semantics/published
Search for flavor changing neutral currents in top quark decays in pp collisions at 7 TeV (2012)

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAM
In re: characterization of benign and metastatic vertebral compression fractures with quantitative diffusion MR imaging. (2003)

We enjoyed reading the recent article by Zhou et al ([1][1]) on the application of quantitative diffusion imaging to the differential diagnosis of benign versus metastatic vertebral compression fractures. This article and the accompanying editorial provided useful insights into both the clinical
Effect of polar side chains on neutral and p-doped polythiophene (2020)

We investigate in detail the optical, electrochemical, structural and electrical properties of polythiophenes with increasing content of polar side chains.
Analysis of self-calibrated field aligned starting (FAS) at mains connection (2009)

Field aligned starting (FAS) is a technique for starting three-phase cage induction motors on either three-phase or single-phase supply lines under varying load conditions with minimal inrush currents. The technique starts the motor independent of the mains supply with a high transient torque before connecting the spinning motor to the mains. It is imperative to the operation of FAS that the spinning motor be connected to the mains at the correct time. Incorrectly timed mains connection can result in negative transient torques with the severity to slow, or possibly stall the already started motor. As the implementation of FAS is not possible without a predictive mechanism by which the correct moment of mains connection can be found in advance, this paper proposes a simple, low cost, yet effective self-calibrating method which ensures that the timing of the mains connection is correct under all starting conditions. Critical issues vital to a successful self-calibration under transient and varying starting conditions are investigated and presented with both experimental and simulated results to show that self-calibration is an indispensable part of FAS technique.
Regulation of alveolar septation by microRNA-489 (2015)

MicroRNAs (miRs) are small conserved RNA that regulate gene expression. Bioinformatic analysis of miRNA profiles during mouse lung development indicated a role for multiple miRNA, including miRNA-489. miR-489 increased on completion of alveolar septation [postnatal day 42 (P42)], associated with decreases in its conserved target genes insulin-like growth factor-1 (Igf1) and tenascin C (Tnc). We hypothesized that dysregulation of miR-489 and its target genes Igf1 and Tnc contribute to hyperoxia-induced abnormal lung development. C57BL/6 mice were exposed to normoxia (21%) or hyperoxia (85% O2) from P4 to P14, in combination with intranasal locked nucleic acid against miR-489 to inhibit miR-489, cytomegalovirus promoter (pCMV)-miR-489 to overexpress miR-489, or empty vector. Hyperoxia reduced miR-489 and increased Igf1 and Tnc. Locked nucleic acid against miR-489 improved lung development during hyperoxia and did not alter it during normoxia, whereas miR-489 overexpression inhibited lung development during normoxia. The 3' untranslated region in vitro reporter studies confirmed Igf1 and Tnc as targets of miR-489. While miR-489 was of epithelial origin and present in exosomes, its targets Igf1 and Tnc were produced by fibroblasts. Infants with bronchopulmonary dysplasia (BPD) had reduced lung miR-489 and increased Igf1 and Tnc compared with normal preterm or term infants. These results suggest increased miR-489 is an inhibitor of alveolar septation. During hyperoxia or BPD, reduced miR-489 and increased Igf1 and Tnc may be inadequate attempts at compensation. Further inhibition of miR-489 may permit alveolar septation to proceed. The use of specific miRNA antagonists or agonists may be a therapeutic strategy for inhibited alveolarization, such as in BPD.
A novel class of low-complexity SISO algorithms for phase-uncertain communications (2005)

In this paper, we present a novel class of simple soft-input soft-output (SISO) detection algorithms for transmission over phase-uncertain channels. In order to limit the complexity, the set of possible phase values (i.e., the interval [0,2pi)) is properly quantized. We then use a forward-backward (FB) algorithm in correspondence to each quantized phase value. The forward and backward metrics computed by the different FB algorithms are properly combined to make the receiver robust against the time-varying phase. We apply the proposed SISO algorithms to perform joint detection and decoding of serially concatenated low-density parity-check (LDPC) codes and differentially encoded (DE) quaternary phase shift keying (QPSK), transmitted over a phase-uncertain channel. As a validation of the effectiveness of the proposed algorithms, we show that the performance loss with respect to that of the corresponding ideal (i.e., perfectly coherent) system is limited. Besides having a limited complexity, the proposed SISO algorithms are blind, i.e., no knowledge of the channel phase statistics is required, and highly parallelizable, as desirable in high-throughput future wireless communication systems
Everyday Eating Experiences of Chocolate and Non-Chocolate Snacks Impact Postprandial Anxiety, Energy and Emotional States (2012)

Social and psychological stressors are both a part of daily life and are increasingly recognized as contributors to individual susceptibility to develop diseases and metabolic disorders. The present study investigated how snacks differing in sensory properties and presentation can influence ratings of affect in consumers with different levels of dispositional anxiety. This study examines the relationships between a pre-disposition to anxiety and food using a repeated exposures design with three interspersed test days over a period of two weeks. The study was conducted on ninety free-living male (n = 28) and female (n = 62) Dutch participants aged between 18 and 35 years old, with a BMI between 18 and 25 kg/m(2) and different anxiety trait levels assessed using State-Trait Anxiety Inventory tests. The study was randomized by age, gender, anxiety trait score, and followed a parallel open design. Three test products: dark chocolate, a milk chocolate snack and crackers with cheese spread (control), which differed in composition, sensory properties and presentation, were evaluated. Changes in self-reported anxiety, emotion, and energetic states were assessed as a function of eating the snacks just after consumption and up to one hour. The repeated exposure design over a period of two weeks enabled the investigations of potential cumulative effects of regular consumption of the food products. The milk chocolate snack resulted in the decrease of anxiety in high anxiety trait subjects, whereas dark chocolate and cheese and crackers respectively improved the anxiety level and the energetic state of low anxiety trait participants. The mood effects were not altered with repeated exposure, and the magnitude of changes was similar on each test day, which illustrates the repeatability of the effects of the food on subjective measures of postprandial wellness.
Pre-clinical toxicology for a potent anti-cancer agent, a human ribonuclease variant (2007)

677 The objective of this study was to determine the pre-clinical toxicology profile of QBI-139, a member of the Evade™ Ribonuclease family, which are a novel class of therapeutic agents being developed for the treatment of cancer. These proteins are variants of the naturally occurring human pancreatic ribonuclease, engineered to evade the native ribonuclease inhibitor. QBI-139 was selected for pre-clinical studies based on tumor growth inhibition in the range of 80-90% in several mouse xenograft models. The efficacy of QBI-139 has been compared to standard chemotherapy agents, including 5-fluorouracil (pancreatic) and cisplatin (lung), as well as newer therapies such as erlotinib (lung), and representative data will be provided. The lead candidate QBI-139 was expressed in inclusion bodies in E. coli and purified by traditional column chromatography. The enzymatic activity was determined using a UV-based assay with cytidine 2’, 3’-cyclic monophosphate as the substrate. QBI-139 was tested for its ability to inhibit the growth of human tumors implanted in the flanks of nude mice (xenograft model). To evaluate the safety of QBI-139, toxicology studies were conducted. Acute dose studies were performed in both mice and rats to determine the maximum tolerated dose (MTD). Clinical observation, body weight, and clinical chemistry were used to identify organ-specific toxicities and determine the reversibility of the toxicities. The animals were dosed by bolus i.v. injection. The MTD for single dose administration in mice and rats was determined. A repeat dose (30 day) study in mice demonstrated the efficacious dose (75-100 mg/kg) is within the safe dose (>200 mg/kg). The pre-clinical toxicology data for QBI-139 supports the development as therapeutic agents. QBI-139 was well tolerated in the dose ranges anticipated to be efficacious.