gebhart/patrepeval huggingface dataset:
The Biocatalytic Transformation of Furan to Amide in the Bioactive Marine Natural Product Palinurin (1999)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTThe Biocatalytic Transformation of Furan to Amide in the Bioactive Marine Natural Product PalinurinKhalid A. El Sayed, Alejandro M. S. Mayer, Michelle Kelly, and Mark T. HamannView Author Information Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences (NCNPR), School of Pharmacy, The University of Mississippi, University, Mississippi, Pharmacology Department, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois, and National Institute of Water & Atmospheric Research Ltd., Auckland, New Zealand Cite this: J. Org. Chem. 1999, 64, 25, 9258–9260Publication Date (Web):November 18, 1999Publication History Received29 March 1999Published online18 November 1999Published inissue 1 December 1999https://pubs.acs.org/doi/10.1021/jo990539jhttps://doi.org/10.1021/jo990539jbrief-reportACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views409Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Carbene compounds,Carbonyls,Metabolism,Nitrogen,Nuclear magnetic resonance spectroscopy Get e-Alerts
Increasing consensus accuracy in DNA fragment assemblies by incorporating fluorescent trace representations. (1997)

We present a new method for determining the consensus sequence in DNA fragment assemblies. The new method, Trace-Evidence, directly incorporates aligned ABI trace information into consensus calculations via our previously described representation, Trace-Data Classifications. The new method extracts and sums evidence indicated by the representation to determine consensus calls. Using the Trace-Evidence method results in automatically produced consensus sequences that are more accurate and less ambiguous than those produced with standard majority-voting methods. Additionally, these improvements are achieved with less coverage than required by the standard methods-using Trace-Evidence and a coverage of only three, error rates are as low as those with a coverage of over ten sequences.
Zinc(II) complexes of 4-aminoantipyrine (AAP). Crystal structure of [Zn(AAP)2Cl2] (2017)

Zinc(II) complexes of 4-aminoantipyrine (AAP), [Zn(AAP)2X2] (X = Cl–, I–) and [Zn(AAP)(CN)2] · 2H2O were prepared and characterized by elemental analysis, IR and NMR (1H & 13C) spectroscopy. The crystal structure of [Zn(AAP)2Cl2] (1) was determined by X-ray crystallography. The structural analysis of 1 shows that the complex exists as a monomeric nonionic molecule with zinc atom bound to two AAP ligands and two chloride ions adopting a distorted tetrahedral geometry. In [Zn(AAP)2(CN)2] · 2H2O, the appearance of a band at 2162 cm–1 in IR and resonances around 142 ppm in the 13C NMR spectra indicated the binding of cyanide to zinc(II).
Morphological Phase Diagram of Biocatalytically Active Ceria Nanostructures as a Function of Processing Variables and Their Properties (2013)

Invited for this month's cover is the group of Dr. Sudipta Seal from University of Central Florida, USA and a collaborator from the University of Kent, UK. The cover picture shows a morphological phase diagram of CeO<sub>2</sub> indicating regions of nanoparticle nanorods and nanocube formation after certain time periods of hydrothermal treatment. Read the full text of the article at page 1446.
Robotic Boreblending: The Future of In-Situ Gas Turbine Repair (2018)

Automation of inspection and repair tasks on complex installations is gaining attention from industries with high-value assets such as aerospace, nuclear and marine. This paper reports on a five degrees of freedom robotic system capable of performing accurate and repeatable repair procedures through a narrow inspection port, which minimizes the cost and downtime associated with unscheduled maintenance. Careful study of the target working volume and repair process informed the design of a robotic probe capable of replicating the operation. Kinematic analysis of the robot's flexible, prismatic and rotary joints was used to define accurate machining paths in 3D space, and the results were verified using an optical motion capture system (accuracy of 0.25 mm). After comprehensive verifications of the constitutive elements, the robotic system was successfully demonstrated for repair of a high-pressure compressor aerofoil in a gas turbine. The results not only proves the ability of the system to address such difficult repair scenarios but also highlights a domain of opportunities in developing specialist robotics for repair of high-value assets, which is a subject to growing global demand.
Deep Learning for Synchronization and Channel Estimation in NB-IoT Random Access Channel (2019)

The central challenge in supporting massive IoT connectivity is the uncoordinated, random access by sporadically active devices. The random access protocol and activity detection have been widely studied, while the auxiliary procedures, such as synchronization, channel estimation and equalization, have received much less attention. However, once the protocol is fixed, the access performance can only be improved by a more effective receiver, through more accurate execution of the auxiliary procedures. This motivates the pursuit of joint synchronization and channel estimation, rather than the traditional approach of handling them separately. The prohibitive complexity of the conventional analytical solutions leads us to employ the tools of deep learning in this paper. Specifically, the proposed method is applied to the random access protocol of Narrowband IoT (NB-IoT), preserving its standard preamble structure. We obtain excellent performance in estimating Time-of-Arrival (ToA), Carrier-Frequency Offset (CFO), channel gain and collision multiplicity from a received mixture of transmissions. The proposed estimator achieves a ToA Root-Mean-Square Error (RMSE) of 0.99 us and a CFO RMSE of 1.61 Hz at 10 dB Signal-to-Noise Ratio (SNR), whereas a conventional estimator using two cascaded stages have RMSEs of 15.85 us and 8.05 Hz, respectively.
The optimization of multipole magnetizing fixtures for high-energy magnets (1990)

Modern high-energy magnetic materials such as samarium-cobalt and neodymium-iron-boron require very large magnetizing fields to achieve full saturation. In some cases the recommended magnetizing field is as high as 40 kOe. Such a field is readily achievable in a large solenoid, and unidirectional magnetization is easily accomplished. Many applications, such as motors and linear actuators, however, require multipole magnets. The problem of designing custom fixtures for multipole magnetization has often been considered more of an art than a science. This paper shows that by mathematically modeling the capacitor discharge magnetizer and the fixture the problem can be solved with reasonable predictability. Two different multipole fixture designs are presented along with the experimental results. The basic equations are presented and used to predict the magnetic-field intensity inside the fixtures. It is shown that optimum performance is achieved when the resistance of the fixture is equal to the parasitic resistance of the magnetizer. Finite-element analysis is also used as part of the design process. The experimental results have been achieved using a high-voltage, low-energy capacitor-discharge magnetizer and air core fixtures. The magnetization patterns that are produced are very sharp and well defined.
Rapid and Robust Detection Methods for Poison and Microbial Contamination (2012)

Real-time on-site monitoring of analytes is currently in high demand for food contamination, water, medicines, and ingestible household products that were never tested appropriately. Here we introduce chemical methods for the rapid quantification of a wide range of chemical and microbial contaminations using a simple instrument. Within the testing procedure, we used a multichannel, multisample, UV-vis spectrophotometer/fluorometer that employs two frequencies of light simultaneously to interrogate the sample. We present new enzyme- and dye-based methods to detect (di)ethylene glycol in consumables above 0.1 wt % without interference and alcohols above 1 ppb. Using DNA intercalating dyes, we can detect a range of pathogens ( E. coli , Salmonella , V. Cholera, and a model for Malaria) in water, foods, and blood without background signal. We achieved universal scaling independent of pathogen size above 10(4) CFU/mL by taking advantage of the simultaneous measurement at multiple wavelengths. We can detect contaminants directly, without separation, purification, concentration, or incubation. Our chemistry is stable to ± 1% for >3 weeks without refrigeration, and measurements require <5 min.
Supplemental Data from <i>In Situ</i> Vaccination with a TLR9 Agonist and Local Low-Dose Radiation Induces Systemic Responses in Untreated Indolent Lymphoma (2023)

&lt;p&gt;Supplemental Tables T1-T3, and Supplemental Figures S1-S5&lt;/p&gt;
Nanodomain Formation on Ferroelectrics and Development of Hard-Disk-Drive-Type Ferroelectric Data Storage Devices (2009)

In this study, several read/write (R/W) tests were conducted using a hard-disk-drive-type ferroelectric data storage test system based on scanning nonlinear dielectric microscopy (SNDM). A periodically inverted signal, which corresponded to artificial domain stripes formed on LiTaO3 single crystal, could be read correctly with a bit rate of 2 Mbps using this test system. Bit writing on a 50-nm-thick epitaxial LiTaO3 film at 20 Mbps was also demonstrated. In addition, a noncontact probe-height control technique was adapted to solve the problem of tip abrasion. The gap distance between a probe and a medium surface was successfully controlled on the nanometer order using a noncontact SNDM technique with sharp-pointed tungsten needle probes prepared by electrolytic polishing. Bit writing under a noncontact state was also studied. Artificial domain dots with diameters of less than 100 nm could be formed under the noncontact state.
Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors (1997)

Mutations in the k-ras and TP53 genes, as well as microsatellite instability (MIN), are frequent genetic alterations in colorectal carcinomas and represent 3 different mechanisms in the carcinogenic process. Both the incidence of colorectal cancer and the frequency of genetic alterations in such tumours have been related to different clinico-pathological variables, including age and gender of the patient and location of the tumour. A number of studies have also reported associations between different types of genetic alterations. We therefore wanted to explore the relationship between these genetic and clinico-pathological variables using multivariate analysis on material from 282 colorectal carcinomas. Three logistic regression models were constructed: 1) the presence of K-ras mutations was dependent on MIN and age and gender of patient, with an especially low frequency among younger males and in tumours with MIN (overall p = 0.0003); 2) the presence of TP53 mutations was only dependent on tumour location, with a positive association to cancers occurring distally (p = 0.002); and 3) the presence of MIN was dependent on age, gender and K-ras and TP53 mutations, as well as on tumour location. MIN was most frequent among younger male and older female patients, was rare in tumours with K-ras or TP53 mutations and was found almost exclusively in the proximal colon (overall p < 0.0001). Our data confirm that different genetic pathways to colorectal cancer dominate in the proximal and distal segments of the bowel and suggest that the K-ras- and MIN-dependent pathways are influenced by different sex-related factors.
On-Board Linear Interference Cancellation Multiuser Detection for Uplink CDMA GEO Satellite Systems (2007)

[Abstract] In this paper, various IC MUD schemes namely SIC, PIC and PPIC are investigated for on-board implementation of uplink CDMA GEO satellite systems. The IC MUD schemes offer low complexity since they utilize matched filtering principle to cancel the MAI. We investigate two-stage IC MUD comparison under 6-dB Rician fading channel for on-board implementation. The results indicate that a two-stage PPIC shows a significant improvement over the conventional PIC and can approach the two-stage SIC performance (that has the best performance, but incurs a relatively large delay in processing and requires users re-ordering accordingly to the received power levels). We also examine the impact of asynchronous transmission and different power distribution to the PPIC performance. The results show that PPIC is most suitable for on-board implementation in CDMA GEO satellite systems.
Methodology for predicting C4 non-wets during the chip attach process (2010)

Balancing the level of substrate warp at reflow with other sources contributing to C4 non-wets is an important problem. To address this, a methodology to predict the probability of non-wets during the chip attach process of an organic package has been developed. A technique for quantifying the convex or concave warp of a substrate in the form of a Shape Inversion (SI) plot is introduced. Geometrical factors that influence non-wets such as C4 height, the pad's relative location, collapsed solder height etc. are described and their individual contributions to the non-wet conditions are computed. Combining these contributions onto the SI plot allows for a graphical representation of the non-wet probability. The technique is applied to a product substrate and the results compared with the actual yield observed during chip assembly.
INVESTIGATING THE ROLE OF PROCESS CONDITIONS IN WASTEWATER SLUDGE ODOR GENERATION (2005)

INVESTIGATING THE ROLE OF PROCESS CONDITIONS IN WASTEWATER SLUDGE ODOR GENERATIONOdor gas production from solids handling processes in wastewater treatment has long been a matter of concern. In this study, the production of malodorous odors from unlimed sludges and biosolids was investigated along with the role of trivalent cations in odor gas generation. The effect of shear and polymer dose on Trimethylamine (TMA) production was also determined. It was found that production...Author(s)Rahul SubramanianJohn T. NovakSudhir MurthyDietmar GlindemannJason NorthSourceProceedings of the Water Environment FederationSubjectSession 80: Residuals & Biosolids Management: Thickening and DewateringDocument typeConference PaperPublisherWater Environment FederationPrint publication date Jan, 2005ISSN1938-6478SICI1938-6478(20050101)2005:9L.6582;1-DOI10.2175/193864705783814844Volume / Issue2005 / 9Content sourceWEFTECFirst / last page(s)6582 - 6604Copyright2005Word count278
Resolution of (±)-threo-Methylphenidate with (R)-(−)-Binaphthyl-2,2‘-diyl Hydrogen Phosphate:  0.5 M Equiv of Resolving Agent Is Better than 1 M Equiv (1999)

Resolution of (±)-threo-methylphenidate (1) with 0.5 M equiv of (R)-(−)-binaphthyl-2,2‘-diyl hydrogen phosphate (4) is described. Use of 0.5 M equiv of 4 was found to be better than 1 M equiv for the resolution of (±)-threo-methylphenidate (1) under different conditions to yield diastereomeric (2R,2‘R)-threo-methylphenidate·(R)-(−)-binaphthyl-2,2‘-diyl hydrogen phosphate salt (3) with excellent enantiopurity. The diastereomeric salt 3 afforded pure (2R,2‘R)-(+)-threo-methylphenidate hydrochloride (2) in high enantiopurity and yield.
Cardiovascular Events in Men with Prostate Cancer Receiving Hormone Therapy: An Analysis of the FDA Adverse Event Reporting System (FAERS) (2021)

In this retrospective analysis of a pharmacovigilance database, arterial vascular events were the most commonly reported cardiovascular adverse events in men on hormone therapy for prostate cancer. GnRH antagonists were associated with fewer reports of overall cardiovascular events and arterial vascular events than GnRH agonists. Additional study is needed to identify optimal strategies to reduce cardiovascular morbidity among men with prostate cancer receiving hormone therapy.
The Australian dingo is an early offshoot of modern breed dogs (2022)

Dogs are uniquely associated with human dispersal and bring transformational insight into the domestication process. Dingoes represent an intriguing case within canine evolution being geographically isolated for thousands of years. Here, we present a high-quality de novo assembly of a pure dingo (CanFam_DDS). We identified large chromosomal differences relative to the current dog reference (CanFam3.1) and confirmed no expanded pancreatic amylase gene as found in breed dogs. Phylogenetic analyses using variant pairwise matrices show that the dingo is distinct from five breed dogs with 100% bootstrap support when using Greenland wolf as the outgroup. Functionally, we observe differences in methylation patterns between the dingo and German shepherd dog genomes and differences in serum biochemistry and microbiome makeup. Our results suggest that distinct demographic and environmental conditions have shaped the dingo genome. In contrast, artificial human selection has likely shaped the genomes of domestic breed dogs after divergence from the dingo.
Design and Implementation of the GHz-Band Wide(6 GHz~18 GHz) Linear Equalizer (2007)

본 논문에서는 <TEX>$6{\sim}18$</TEX> GHz의 넓은 대역에서 진폭 선형성을 얻기 위해, 인접 전송선-스터브 블록 간에 저항이 삽입된, 마이크로스트립형의 선형 진폭 등화기가 구현된다. 선형성과 반사 손실 특성을 만족하도록 저항과 스터브의 값들이 변화하며, 적합한 수치를 찾으면서 설계가 이뤄진다. 실험치는 본 구현 결과는 <TEX>$6{\sim}18$</TEX> GHz에서 요구되는 약 9 dB의 선형도와 약 10 dB 이하의 반사 손실이 얻어지고, 설계 기법의 타당함을 보인다. In this paper, a microstripline-type linear amplitude equalizer is implemented to achieve the linearity of the slope of the amplitude over <TEX>$6{\sim}18$</TEX> GHz with resistors inserted between their immediate pairs of a TX-line and a stub. The values of resistors and stubs are explored to have the optimal linear slope and return loss performance. Experiments reveal the slope of around 9 dB variation and return loss of less than 10 dB desired over <TEX>$6{\sim}18$</TEX> GHz and validate the design methodology.
Self-assembly in space via self-reconfigurable robots (2004)

Self-assembly systems in space are arguably within the reach of today's technology based on the research and development of self-reconfigurable robots on earth. This paper presents an approach to self-assembly in space by developing: (1) a novel design for intelligent and reconfigurable components; (2) the free-flying "intelligent fiber/rope" "match-maker" robots with self-reconfigurable and self-adjustable tethering for autonomous docking; and (3) a totally distributed control method for planning, executing, and monitoring the assembly process. These approaches are partially evaluated by a set of experimental and simulation results to simulate the dynamics and control of free-flying objects in zero-gravity environment.
Booster propulsion/vehicle impact study (1988)

The use of hydrogen RP-1, propane, and methane as fuels for booster engines of launch vehicles is discussed. An automated procedure for integrated launch vehicle, engine sizing, and design optimization was used to define two stage and single stage concepts for minimum dry weight. The two stage vehicles were unmanned and used a flyback booster and partially reusable orbiter. The single stage designs were fully reusable, manned flyback vehicles. Comparisons of these vehicle designs, showing the effects of using different fuels, as well as sensitivity and trending data, are presented. In addition, the automated design technique utilized for the study is described.
BLOOD-SOLUBLE DRAG-REDUCING POLYMERS AS A POTENTIAL TREATMENT OF HEMODYNAMIC IMPAIRMENT IN DIABETIC RATS (2005)

BACKGROUND: Diabetes is associated with generalized afflictions of the cardiovascular system. Current therapies can at best delay the onset of these complications. Intravenous injections of blood-soluble drag reducing polymers (DRPs) were shown to increase blood flow and tissue perfusion and reduce vascular resistance without affecting the vessel wall. We hypothesized that DRPs might enhance the microcirculation which is thought to be reduced in diabetes. METHODS: Diabetes was induced in 7 rats after a single dose of streptozotocin (vehicle in controls, n = 8) and characterized by blood glucose levels of 300–400 vs. 80–90 mg/dl in controls. Insulin (0.5–3 U) was administered to maintain blood glucose levels below 450 mg/dl. After 15 weeks of hyperglycemia, DRPs were injected IV at a final concentration of 1 ppm following recording of base hemodynamic parameters in acute experiments. Blood samples were collected before and after DRP infusion. RESULTS: Body weight, tissue perfusion (TP), MAP and heart rate were significantly lower and vascular resistance and hematocrit were both significantly higher in diabetic animals. An injection of DRPs increased TP by ∼40% in both control and diabetic rats with no significant change in MAP. CONCLUSIONS: This study demonstrated that DRPs were able to improve impaired TP in diabetic animals and may represent a new rheological method for the treatment of impaired microcirculation in diabetes.
A multistatic feeding concept for beam steering based on a dielectric ellipsoidal antenna (2012)

A simple and easy to integrate concept for multi-static beam steering using an existing dielectric ellipsoidal lens antenna is presented in this paper. Good antenna characteristics allow a modification of the antenna for the desired beam steering for industrial applications at 24 GHz. Based on the so-called geometrical-optical lens approach and 3D-electromagnetic field simulations the concept is investigated and the resulting effects of the modification are depicted. The antenna beam can be steered within a range only limited by the antenna dimensions. Using multiple feeding elements in one antenna within the same plane, a multistatic beam steering can be realized. For the multistatic approach, the circular waveguides for the antenna feeding are limiting the achievable steering angles, due to the minimal distance between two waveguides. Measurements of a first prototype confirm the expected behaviour and demonstrate the applicability for industrial purposes. Hence, the concept is suitable for the realization of multiple beam angles using only one antenna for a chosen number of feeding points.