gebhart/patrepeval huggingface dataset:
Automated Tuning of Nonlinear Kalman Filters for Optimal Trajectory Tracking Performance of AUVs (2023)

The performance of navigation algorithms significantly determines the trajectory tracking accuracy of the guidance, navigation, and control (GNC) system of an autonomous underwater vehicle (AUV). In closed-loop operation, the interaction among path planning, control, and navigation plays a crucial role in the tracking accuracy of the overall GNC system. A Doppler velocity log (DVL) is often used for AUVs to measure velocity over the ground, positively affecting the closed-loop tracking error. However, a DVL may not be installed in miniaturized AUVs due to limited space and energy. In this paper, a navigation filter for an underactuated miniature AUV (nanoAUV) is considered that is mainly based on acoustic localization using a novel highly-miniaturized ultra-short baseline (USBL) system and a depth pressure sensor. The nanoAUV is being developed for subglacial lake exploration. We compare two unscented Kalman filters (UKF) with different prediction models - the classical strapdown inertial navigation systems (SINS) model and a hydrodynamic motion model (HMM). To enable a fair comparison, filter parameters are auto-tuned with Bayesian optimization (BO) for open and closed-loop performance, which is novel in AUV navigation. The results indicate that BO performs similarly to particle swarm optimization (PSO) regarding sample efficiency for the proposed problem. To quantify the GNC tracking performance, we use extensive Monte Carlo simulations. Results suggest that with BO-tuned navigation filter parameters, the median tracking error is reduced by up to 50% compared to default parametrization.
Implementation of non-invasive Filter-Exchange Imaging (FEXI) to measure blood-brain barrier water exchange in the rat brain (2023)

We have developed a preclinical FEXI sequence optimised to measure water exchange across the blood-brain barrier in the rat brain. Simulated synthetic data estimated an apparent exchange rate (AXR) of 1.22 s -1 , using the in-vivo acquisition parameters and exchange rate constant = 2.5 s -1 , reflecting in-vivo measurements. The experimental normalised AXR in the rat brain was measured at 3.34 &amp;plusmn; 1.14 s -1 (scan) and 3.62 &amp;plusmn; 0.96 s -1 (rescan), with CoV = 26%, n = 10. This technique is a promising non-invasive tool which can be applied to in a wide range of disease models, including neurodegeneration, stroke and neuroinflammation.
In silico screening of the effectiveness of natural compounds from algae as SARS-CoV-2 inhibitors: molecular docking, ADMT profile and molecular dynamic studies (2022)

Marine species are known as rich sources of metabolites largely involved in the pharmaceutical industry. This study aimed to evaluate in silico the effect of natural compounds identified in algae on the SARS-CoV-2 Main protease, RNA-dependent-RNA polymerase activity (RdRp), endoribonuclease (NSP15) as well as on their interaction with viral spike protein. A total of 45 natural compounds were screened for their possible interaction on SARS-CoV-2 target proteins using Maestro interface for molecular docking, molecular dynamic (MD) simulation to estimate compounds binding affinities. Among the algal compounds screened in this study, three (Laminarin, Astaxanthin and 4'-chlorostypotriol triacetate) exhibited the lowest docking energy and best interaction with SARS-CoV-2 viral proteins (Main protease, RdRp, Nsp15, and spike protein). The complex of the main protease with laminarin shows the most stable RMSD during a 150 ns MD simulation time. Which indicates their possible inhibitory activity on SARS-CoV-2.Communicated by Ramaswamy H. Sarma.
Interferon-&#947;-Induced Neurotoxicity of Human Astrocytes (2015)

Activated astrocytes, which can also be referred to as reactive astrocytes or astrogliosis, have been identified in affected regions of common neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and multiple sclerosis. Activated astrocytes may be beneficial, promoting neuronal survival due to their production of growth factors and neurotrophins. Activated astrocytes can also be detrimental to neighboring neurons in neuroinflammatory processes. Astrocytes exposed to certain inflammatory stimulants in vitro have been shown to release potentially neurotoxic molecules, including inflammatory cytokines, glutamate, nitric oxide and reactive oxygen species. It has recently been shown that adult human astrocytes stimulated with interferon-γ, a common inflammatory cytokine evidently present in neuropathological brains, exert potent neurotoxicity in vitro. This interferon- γ-induced astrocytic neurotoxicity is mediated by the activation of the Janus kinase-signal transducer and activator of transcription (STAT) 3 pathway in the astrocytes, and involves intracellular phosphorylation of STAT3 at tyrosine-705 residue. Therefore, control of STAT3 activation in human astrocytes may be a promising new therapeutic strategy for a broad spectrum of neurodegenerative and neuroinflammatory disorders where activated astrocytes may contribute to the pathology.
Correction of translational motion artifacts in multi‐slice spin‐echo imaging using self‐calibration (1993)

In this paper, we describe a method for detecting and correcting in-plane bulk translational motion in multislice spin-echo imaging using self-calibration and postprocessing. A constant phase encoding offset between slices is used to evenly spread out the low spatial frequency echoes to allow accurate motion detection by self-calibration. Motion detection in both x and y directions is achieved by interchanging the readout and phase encoding directions for the alternate slices. Displacements are determined by cross correlating the modulus of each 1D transformed echo with a reference box car function whose width equals that of the imaged object. In addition, phase errors induced by the velocity in the readout direction are estimated and corrected using the displacement data. The results obtained from knee studies at 0.5 T and 1.5 T show that the artifacts due to translational motions are significantly suppressed upon correction. The method does not require any additional pulses or time, and the data processing can be easily implemented.
Protective effect of DNA immunization against mycobacterial infection is associated with the early emergence of interferon-gamma (IFN-γ)-secreting lymphocytes (2000)

The development of more effective anti-tuberculosis (TB) vaccines would contribute to the global control of TB. Understanding the activated/memory T cell response to mycobacterial infection and identifying immunological correlates of protective immunity will facilitate the design and assessment of new candidate vaccines. Therefore, we investigated the kinetics of the CD4+ T cell response and IFN-gamma production in an intravenous challenge model of Mycobacterium bovis bacille Calmette-Guérin (BCG) before and after DNA immunization. Activated/memory CD4+ T cells, defined as CD44hiCD45RBlo, expanded following infection, peaking at 3-4 weeks, and decreased as the bacterial load fell. Activated/memory CD4+ T cells were the major source of IFN-gamma and the level of antigen-specific IFN-gamma-secreting lymphocytes, detected by ELISPOT, paralleled the changes in bacterial load. To examine the effects of a DNA vaccine, we immunized mice with a plasmid expressing the mycobacterial secreted antigen 85B (Ag85B). This led to a significant reduction in mycobacteria in the liver, spleen and lung. This protective effect was associated with the rapid emergence of antigen-specific IFN-gamma-secreting lymphocytes which were detected earlier, at day 4, and at higher levels than in infected animals immunized with a control vector. This early and increased response of IFN-gamma-secreting T cells may serve as a correlate of protective immunity for anti-TB vaccines.
Micronization of MgFe<sub>2</sub>O<sub>4</sub> particles doped with Si (2016)

The effect of Si addition was studied for the purpose of the improvement of microstructure of MgFe2O4 particles prepared from a malic acid complex. There were no traces of any impurity phase in Si-doped and pure MgFe2O4 powders both in XRD measurements. When Si atoms were doped to MgFe2O4, crystallite growth of MgFe2O4 was remarkably suppressed, and the lattice volume increased up to 10 mol% Si monotonously. SEM observations revealed that MgFe2O4 powders show a granulation shape such as the aragonite and each particle tightly interconnected each other, whereas smaller particles compared with pure MgFe2O4 were observed for Si-doped MgFe2O4. Also, it was found that the amount of mesopore increases by Si doping. Further, XPS and XAS measurements suggested that Si atoms exist in MgFe2O4 crystal.
Low Delay Filterbanks for Enhanced Low Delay Audio Coding (2007)

Low delay perceptual audio coding has recently gained wide acceptance for high quality communication. While common schemes are based on the well-known Modified Discrete Cosine Transform (MDCT) filterbank, this paper describes novel coding algorithms that, for the first time, make use of dedicated low delay filterbanks, thus achieving improved coding efficiency while maintaining or even reducing the low codec delay. The MPEG-4 Enhanced Low Delay AAC (AAC-ELD) coder currently under development within ISO/MPEG combines a traditional perceptual audio coding scheme with spectral band replication (SBR), both running in a delay-optimized fashion by using low delay filterbanks.
A Combined On-Line PCA-ICA Algorithm for Blind Source Separation (2005)

In this paper, we introduce and investigate a method combining principle component analysis (PCA) and independent component analysis (ICA) for blind source separation (BSS). A recursive method for the PCA is applied to meet the demands of a real-time application, and likewise a modified on-line version of the information maximization principle is used. The combined PCA-ICA algorithm, first reduces the dimension of the problem and then separates the signals. Evaluation of the proposed algorithm in a real room shows superior noise suppression capabilities compared to the use of PCA or ICA individually. The proposed algorithm achieves an impressive noise suppression/separation of up to 14 dB with only two microphones. Most importantly this is achieved with negligible distortion of the recovered signal.
The effects of buoyancy on sonoluminescing bubbles (2000)

Sonoluminescence from a single bubble was studied under microgravity and hypergravity environments to determine how buoyancy affects the light emission. The long-term objective of these experiments is to determine if buoyancy-related instabilities play a role in limiting the parameter space of single-bubble sonoluminescence. Understanding the parameter space limitations may ultimately lead to novel approaches for enhancing the extreme conditions within the bubble. Our results reveal several buoyancy-related effects, which should be further investigated in an extended microgravity environment.
INTERDIFFUSION STUDIES OF HIGH-K GATE DIELECTRIC STACK CONSTITUENTS (2006)

stability of various high-κ gate dielectric materials. The role of film morphology and the resultant interdiffusion are also discussed. This paper presents a summary of recent studies of the thermal
The ATM layer chip: an ASIC for B-ISDN applications (1991)

The authors describe the architecture of an experimental research prototype application specific integrated circuit (ASIC) designed to serve as a generic building block of the future broadband integrated services digital network (B-ISDN). The chip performs common asynchronous transfer mode (ATM) layer functions such as cell assembly and cell disassembly. A new media access control (MAC) protocol developed for a broadband customer premises network is also integrated in the chip. The chip interfaces to the B-ISDN through a synchronous optical network (SONET) synchronous transmission signal-3c (STS-3c) framer chip. The ATM layer chip has been designed using 1.2 mu m CMOS technology with a die area of 5.4*5.4 mm/sup 2/ and approximately 27000 transistors. Experimental results are described. At the user network interface, the chip can be used to implement broadband terminal adaptors and the network termination. At the broadband local exchange, the chip can be used in the implementation of ATM statistical multiplexers, ATM switch port controllers, etc.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Nurr1 dependent regulation of pro-inflammatory mediators in immortalised synovial fibroblasts (2005)

Abstract Background Nurr1 is an orphan member of the nuclear receptor superfamily; these orphan receptors are a group for which a ligand has yet to be identified. Nurr1 has been shown to regulate the expression of a small number of genes as a monomeric, constitutively active receptor. These Nurr1 regulated genes are primarily associated with dopamine cell maturation and survival. However, previous reports have shown an increased expression of Nurr1 in the synovium of patients with rheumatoid arthritis (RA) suggesting a pro-inflammatory role for Nurr1 in RA. In this study we investigate the potential pro-inflammatory role of Nurr1 by monitoring Nurr1 dependent gene expression in an immortalised synoviocyte cell line, K4IM. Methods We overexpressed the wild type and a dominant negative form of the orphan nuclear receptor Nurr1, in a model synoviocyte cell line. Using the Affymetrix HG-U133 Genechips we demonstrate the effects on the transcriptome by the receptor. Further evidence of gene expression change was demonstrated using quantitative RT-PCR and ELISA analysis. Results We show that Nurr1 regulates transcription of a small number of genes for pro-inflammatory modulators of which the most significant is interleukin-8 (IL-8). We also demonstrate increased synthesis and secretion of IL-8 further supporting a role for Nurr1 in inflammatory signalling pathways. Conclusion Using microarray analysis we show that elevated levels of Nurr1 leads to increased gene expression of pro-inflammatory genes: IL-8, Amphiregulin and Kit ligand in a model cell line. This data provides further evidence for an additional role for Nurr1 in inflammation and may play a role in the pathogenesis of rheumatoid arthritis.
Experimentelle Untersuchungen zu Mittelohrimplantaten mit integriertem mikromechanischem Gelenk (2007)

The insertion of the new silicone bordered micro joint into a TORP shaft provides an effective method to decrease the potentially damaging stapes footplate excursions after complete ossicular reconstruction. Limited deflections of the prosthesis shaft reduce the occurring forces on the stapes footplate as they partly bore the quasi static pressure changes. Thus, the micro joint can reduce the risk of prostheses dislocation and annular ligament damage and is additionally providing a proper sound transmission through the reconstructed middle ear. Moreover, the bionic modification of a TORP reflects the remaining possibilities for further improvements in prosthetic reconstruction.
Laser-Based Mass Flow Rate Sensor Onboard HFiRE Flight 1 (2009)

The development of an optical mass capture sensor system for use onboard hypersonic flights under the HIFiRE program is discussed. The inlet flow velocity is determined directly from the Doppler shift of oxygen absorption lines centered about 760 nm with the use of wavelength modulation spectroscopy for high-sensitivity measurements. A compact, low weight and volume design are required for a flight-ready sensor system having minimum power consumption. The required tests for qualifying the instrument for flight are discussed. The sensor system completed successfully all qualification tests, and is on standby for launch 2010.
Experimental and theoretical study of methane adsorption on granular activated carbons (2011)

Abstract The experimental and theoretical study of methane adsorption on granular activated carbons is presented. The adsorption data are modeled by various isotherm equations. Toth equation is found to have the best fit. The isosteric heat decreases with loading and increases weakly with temperature, which is an indication of heterogeneity of the methane and granular activated carbon system. Using optimized parameters from Toth equation, a novel procedure is developed to calculate the integral heat of adsorption, which is the total amount of isosteric heat of adsorption at a given temperature and pressure during the adsorption process. © 2011 American Institute of Chemical Engineers AIChE J, 2012
Abstract 16967: A Clinical Assessment in Diastolic Heart Failure: The Correlation Between a Combination of Clinical Findings and Indices with Echocardiography in Hemodialysis Outpatients (2012)

Purpose: Ideal design of non-invasive assessments for diastolic heart failure (DHF) remains limited due to the lack of modest clinical criteria to describe the patients. Numerical scoring systems t...
Kinetics and Spectroscopy of Substituted Phenylnitrenes (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Optimized Interactions for Targeted Self-Assembly: Application to a Honeycomb Lattice (2005)

We devise an inverse statistical-mechanical methodology to find optimized interaction potentials that lead spontaneously to a target many-particle configuration. Target structures can possess varying degrees of disorder, thus extending the traditional idea of self-assembly to incorporate both amorphous and crystalline structures as well as quasicrystals. For illustration purposes, our computational technique is applied to yield an optimized isotropic (nondirectional) pair potential that spontaneously yields the three-coordinated honeycomb lattice as the ground state structure in two dimensions. This target choice is motivated by its three-dimensional analog, the diamond lattice, which is known to possess desirable photonic band gap properties.
Ordonnancement des tâches pour radar multifonction avec contrainte en temps dur et priorité (2016)

RADARS A ANTENNES ELECTRONIQUES RADAR 2014 64 REE N°5/2015 Ordonnancement des tâches pour radar multifonction avec contrainte en temps dur et priorite Par Vincent Jeauneau1 , Frederic Barbaresco2 , Thomas Guenais2 LIP6, UPMC1 ,Thales Air Systems, Advanced Radar Systems2 This paper presents the radar tasks problem for a set of tasks called Hard Time Constraint tasks which cannot delay their processing by more than a positive constant and for a set of tasks called Soft Time Constraint tasks which can be processed at any time. For solving this problem, we present a method based upon an heuristic sequencing STC tasks and a selection rule determining which task has to be scheduled between the first task of both sequences. ABSTRACT Introduction Les radars multifonction utilisent des antennes a balayage electronique permettant de pointer leurs faisceaux electromagnetiques presque instanta- nement suivant deux axes en azimut et en elevation. Cette flexibilite accroit l’agi- lite du senseur et permet au radar de realiser plusieurs fonctions avec la meme antenne, telles que la surveillance volu- mique de l’espace, la poursuite de cibles menacantes, la reconnaissance no
Metabolic products of microorganisms. Part 262. The absolute configuration of sphydrofuran, a widespread metabolite from streptomycetes (1991)

Abstract Sphydrofuran ( 1 ) was isolated from the culture filtrate of Streptomyces sp. (strain Gö 28 and Tü 3616) by chemical screening methods. Metabolite 1 is an anomeric and ring‐chain tautomeric mixture and could easily be transformed into the stable furan derivative 2 under acidic conditions. The constitution and relative configuration of 1 was established by X‐ray crystallography of its 8‐ O ‐methyl derivative 3a. The absolute configuration at C(4) of 1 and thus of the whole molecule (3 R ,4 S ,5 S ) could be determined starting from 2 using the Helmchen method.
Advanced Sensors for CMC Gas Turbine Engine Components (2019)

Next generation gas turbine engines used for propulsion purposes will utilize ceramic matrix composite (CMC) components in the engine hot section to achieve higher engine operating temperatures and higher thermal efficiencies. Within the engine hot section, rotating components can experience temperatures above 1000°C and g-forces over 50,000g. Therefore, it is important to monitor temperature and strain of these CMC components under these harsh conditions, such that structural models can be verified and new designs can be evaluated. However, conventional wire instrumentation is not well suited for such applications since the sensors and leads cannot be welded to the CMC components and the CMC surfaces cannot be altered. Temperature and strain sensors have been developed for SiC-SiC CMC's, which rely on the semiconducting properties of the SiC-SiC substrate itself to generate large and reliable resistive, piezoresistive, and thermoelectric responses with the added advantage of minimal intrusion, negligible mass, and fast response times. At temperatures > 1000°C, oxidation, small diffusional distances, and microstructural changes can lead to signal drift and thus coatings were developed to ensure the integrity of the semiconductor: metal contacts in these sensors. Results of temperature and strain testing will be presented as well as the fabrication steps used to make the sensors.
Vibration properties of biomimetic tympanic membrane replacements made of polycaprolactone produced by the Melt Electro Writing (2021)

Introduction It was investigated whether it is possible to produce scaffolds from polycaprolactone (PCL) as a functional synthetic human tympanic membrane replacement for full defects using the new additive process Melt Electro Writing (MEW).
An exploration of climate data using complex networks (2009)

To discover patterns in historical data, climate scientists have applied various clustering methods with the goal of identifying regions that share some common climatological behavior. However, past approaches are limited by the fact that they either consider only a single time period (snapshot) of multivariate data, or they consider only a single variable by using the time series data as multi-dimensional feature vector. In both cases, potentially useful information may be lost. Moreover, clusters in high-dimensional data space can be difficult to interpret, prompting the need for a more effective data representation. We address both of these issues by employing a complex network (graph) to represent climate data, a more intuitive model that can be used for analysis while also having a direct mapping to the physical world for interpretation. A cross correlation function is used to weight network edges, thus respecting the temporal nature of the data, and a community detection algorithm identifies multivariate clusters. Examining networks for consecutive periods allows us to study structural changes over time. We show that communities have a climatological interpretation and that disturbances in structure can be an indicator of climate events (or lack thereof). Finally, we discuss how this model can be applied for the discovery of more complex concepts such as unknown teleconnections or the development of multivariate climate indices and predictive insights.
Photopolymerization without Light. Polymerization of Acrylates Using Oxalate Esters and Hydrogen Peroxide (2006)

We define the photopolymerization of acrylates without light as a process wherein the radical chain polymerization produced by photoinitiators are produced by nonphotochemical means. We use the chemical reactions of the chemiluminescent lightstick to accomplish this. An important potential application is in producing “photopolymers” in areas that are not light accessible as in the inside of a tube or behind a pipe. Polymerizable acrylate mixtures containing dissolved oxalate esters undergo radical chain polymerization when exposed to a flow of nitrogen gas saturated with hydrogen peroxide vapors. We propose aryloxyoxalyl hydroperoxides to be the reactive species.