gebhart/patrepeval huggingface dataset:
3W CW Generation at 589nm with Narrow Line Linearly Polarized Raman Fibre Laser (2006)

26W, 0.4nm linewidth CW Raman generation is achieved in linearly polarized singlemode fibre and applied to efficient, over 3W 589nm generation in MgO-PPLN. Watts level generation at any wavelength 550nm to 780nm is feasible.
1H NMR Spectroscopy of the Hydrogen-Bonded Imide Groups of Hub(M)3:3CA Provides a Useful Method for the Characterization of These Aggregates (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1H NMR Spectroscopy of the Hydrogen-Bonded Imide Groups of Hub(M)3:3CA Provides a Useful Method for the Characterization of These AggregatesEric E. Simanek, Mohammed I. M. Wazeer, John P. Mathias, and George M. WhitesidesCite this: J. Org. Chem. 1994, 59, 17, 4904–4909Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/jo00096a037https://doi.org/10.1021/jo00096a037research-articleACS PublicationsRequest reuse permissionsArticle Views250Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Formation of Social Ties Influences Food Choice: A Campus-Wide Longitudinal Study (2021)

Nutrition is a key determinant of long-term health, and social influence has long been theorized to be a key determinant of nutrition. It has been difficult to quantify the postulated role of social influence on nutrition using traditional methods such as surveys, due to the typically small scale and short duration of studies. To overcome these limitations, we leverage a novel source of data: logs of 38 million food purchases made over an 8-year period on the Ecole Polytechnique Federale de Lausanne (EPFL) university campus, linked to anonymized individuals via the smartcards used to make on-campus purchases. In a longitudinal observational study, we ask: How is a person's food choice affected by eating with someone else whose own food choice is healthy vs. unhealthy? To estimate causal effects from the passively observed log data, we control confounds in a matched quasi-experimental design: we identify focal users who at first do not have any regular eating partners but then start eating with a fixed partner regularly, and we match focal users into comparison pairs such that paired users are nearly identical with respect to covariates measured before acquiring the partner, where the two focal users' new eating partners diverge in the healthiness of their respective food choice. A difference-in-differences analysis of the paired data yields clear evidence of social influence: focal users acquiring a healthy-eating partner change their habits significantly more toward healthy foods than focal users acquiring an unhealthy-eating partner. We further identify foods whose purchase frequency is impacted significantly by the eating partner's healthiness of food choice. Beyond the main results, the work demonstrates the utility of passively sensed food purchase logs for deriving insights, with the potential of informing the design of public health interventions and food offerings.
Deep neural network heatmaps capture Alzheimer's disease patterns reported in a large meta-analysis of neuroimaging studies (2022)

Deep neural networks currently provide the most advanced and accurate machine learning models to distinguish between structural MRI scans of subjects with Alzheimer's disease and healthy controls. Unfortunately, the subtle brain alterations captured by these models are difficult to interpret because of the complexity of these multi-layer and non-linear models. Several heatmap methods have been proposed to address this issue and analyze the imaging patterns extracted from the deep neural networks, but no quantitative comparison between these methods has been carried out so far. In this work, we explore these questions by deriving heatmaps from Convolutional Neural Networks (CNN) trained using T1 MRI scans of the ADNI data set, and by comparing these heatmaps with brain maps corresponding to Support Vector Machines (SVM) coefficients. Three prominent heatmap methods are studied: Layer-wise Relevance Propagation (LRP), Integrated Gradients (IG), and Guided Grad-CAM (GGC). Contrary to prior studies where the quality of heatmaps was visually or qualitatively assessed, we obtained precise quantitative measures by computing overlap with a ground-truth map from a large meta-analysis that combined 77 voxel-based morphometry (VBM) studies independently from ADNI. Our results indicate that all three heatmap methods were able to capture brain regions covering the meta-analysis map and achieved better results than SVM coefficients. Among them, IG produced the heatmaps with the best overlap with the independent meta-analysis.
Blood Pharming – eine realistische Option? (2021)

Zusammenfassung Die Bluttransfusion ist ein wesentlicher und unersetzlicher Teil der modernen Medizin. Jedoch stellt vor allem bei Patienten mit sehr seltenen Blutgruppenkonstellationen der Mangel an Blutprodukten auch heute noch ein wichtiges Gesundheitsproblem weltweit dar. Um diesem Problem entgegenzutreten, versucht man seit einiger Zeit künstlich rote Blutzellen zu generieren. Diese haben potenzielle Vorteile gegenüber Spenderblut, wie z. B. ein verringertes Risiko für die Übertragung von Infektionskrankheiten. Diese Übersicht fasst die aktuellen Entwicklungen über den Prozess der Erythropoese, die Expansionsstrategien der erythrozytären Zellen, der verschiedenen Quellen für ex vivo expandierte Erythrozyten, die Hürden für die klinische Anwendung und die zukünftigen Möglichkeiten der Anwendung zusammen.
A DNA-Based Method for Rationally Assembling Nanoparticles into Macroscopic Materials* (2020)

The chemistry proposed focuses on merging the chemistry of DNA with the chemistry of inorganic colloidal materials. In contrast, the DNA-modified Au nanoparticles reported here are stable at elevated temperatures and in aqueous 0.1 M NaC1 solutions for days, presumably because their DNA-modified surfaces prohibit them from getting close enough to undergo particle growth. An advantage of the DNA/colloid hybrid materials reported herein is that the assemblies can be characterized easily by transmission electron microscopy (TEM) and/or atomic force microscopy as well as spectroscopic methods conventionally used with DNA. TEM images of the colloids linked with hybridized DNA show large assembled networks of the Au colloids. In the absence of DNA, the ultraviolet-visible spectrum for the naked Au colloids is much less temperature-dependent. There is a substantial optical change when the polymeric DNA—colloid precipitate is heated its melting point.
3 d Transition Metal‐Catalyzed Hydrogenation of Nitriles and Alkynes (2020)

Selective hydrogenation of nitriles and alkynes is crucial considering the vast applications of reduced products in industries and in the synthesis of bioactive compounds. Particularly, the late 3d transition metal catalysts (manganese, iron, cobalt, nickel and copper) have shown promising activity for the hydrogenation of nitriles to primary amines, secondary amines and imines. Similarly, semihydrogenation of alkynes to E- and Z-alkenes by 3d metals is adequately successful both via the transfer hydrogenation and by using molecular hydrogen. The emergence of 3d transition metals in the selective synthesis of industrially relevant amines, imines and alkenes makes this protocol more attractive. Herein, we provide a concise overview on the late 3d transition metal-catalyzed hydrogenation of nitriles to amines and imines as well as semihydrogenation of alkynes to alkenes.
Compact 200 line MATLAB code for inverse design in photonics by topology optimization: tutorial: erratum (2021)

This paper corrects an error in the software provided with J. Opt. Soc. Am. B 38 , 510 ( 2021 ) JOBPDE 0740-3224 10.1364/JOSAB.405955 .
Performance of pheromone model for predicting traffic congestion (2006)

Social insects perform complex tasks without top-down-style control, by sensing and depositing chemical markers called "pheromone". We have examined applications of this pheromone paradigm towards realizing intelligent transportation systems (ITS). Many of the current traffic management approaches require central processing with the usual risks of overload, bottlenecks and delay. Our work points towards a more decentralized approach that may overcome those risks. We use new category of the ITS infrastructure called the probe-car system. The probe-car system is an emerging data collection method, in which a number of vehicles are used as moving sensors to detect actual traffic situations. In this paper, a car is regarded as a social insect that deposits multi-semantics of (digital) pheromone on the basis of sensed traffic information. We have developed a basic model for predicting traffic congestion in the immediate future using pheromone. In the course of our experimentation, we have identified the need to properly tune the model to achieve acceptable performance. Therefore, we refined the model for practical use. We evaluate our method using real-world traffic data and results indicate applicability to prediction. Furthermore, we describe the practical implications of this method in the real world.
A 92 GHz Bandwidth Distributed Amplifier in a 45 nm SOI CMOS Technology (2011)

A low-power cascode distributed amplifier is demonstrated in a 45 nm silicon-on-insulator (SOI) CMOS process. The amplifier achieves a 3 dB bandwidth of 92 GHz. The peak gain is 9 dB with a gain-ripple of less 1.5 dB over the 3 dB bandwidth. The group-delay variation is under ±4.7 ps over the 3 dB bandwidth. The amplifier consumes 73.5 mW from a 1.2 V supply and results in a gain-bandwidth efficiency figure of merit of 3.53 GHz/mW. The chip occupies an area of 0.45 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> including the pads.
ChemInform Abstract: SYNTHESIS AND MOLECULAR STRUCTURE OF THE TRINUCLEAR CLUSTER COMPOUND (η5‐C5ME5)IRFE2(CO)9 (1982)

Abstract Die Reaktion des Fe‐Carbonyls (II) mit dem zweikernigen Ir‐Komplex (I) in Benzol bei 50°C liefert neben der Verbindung (IV) den neuen luftstabilen, thermisch bis 135°C beständigen, gemischten Fe‐Ir‐Cluster (III).
Detection of Viral RNA in CD4 - CD8 - and CD4 - CD8 + Lymphocytes in Vivo in Rhesus Monkeys Infected with Simian Immunodeficiency Virus of Macaques (2001)

A definition of the specific cell types that support HIV replication early in the course of infection will be important for understanding AIDS pathogenesis and designing strategies for preventing infection. Observations have indicated that the population of lymphocytes susceptible to productive infection extends beyond activated CD4(+) T cells. To explore this issue, we have employed laser scanning cytometry technology and the techniques of lymphocyte surface immunophenotyping followed by fluorescent in situ hybridization to detect simian immunodeficiency virus of macaques (SIVmac) RNA in phenotypically defined rhesus monkey lymphocytes. The immunophenotype of productively infected cells in either a rhesus monkey T cell line or in PBMCs infected in vitro with SIVmac was remarkably similar to that observed in productively infected PBMCs obtained from monkeys during primary infection. We observed low levels or no detectable expression of CD4 on cells infected in vitro or on PBMCs of infected monkeys. However, a substantial number of SIVmac-infected PBMCs both in cultured lymphocytes and sampled directly from infected monkeys expressed CD8 but not CD4. These observations are consistent with the possibility that the CD4 molecule may be modulated off the surface of CD4(+)CD8(-) or CD4(+)CD8(+) lymphocytes after infection or that infection occurred via a CD4-independent mechanism. Moreover, there was no preferential expression of CD25 on cells positive for SIVmac RNA, which might have been predicted if replication of the virus was occurring selectively in activated lymphocytes. These results broaden the range of lymphocytes that support productive SIVmac infection to include CD4(-)CD8(-) and CD4(-)CD8(+) subsets, and are consistent with virus replication occurring in nonactivated cells.
ChemInform Abstract: An Efficient Synthesis of Mimetics of Neamine for RNA Recognition. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Remotely powered optical switch for remote subscriber aggregation and OTDR measurement in PON (2007)

We present for the first time remote powering of a 3-D MEMS for optical switching using light over fibre. The low power switch with integrated optical splitters is suitable at non-powered remote PON distribution sites. (2 pages)
Growth inhibition and augmentation of mouse myeloid leukemic cell line differentiation by interleukin 1. (1987)

The effect of interleukin 1 (IL 1) on the growth and differentiation of mouse myeloid leukemic cell line (M1) cells into macrophages has been studied. Purified human IL 1 beta appeared to be growth inhibitory (maximum, 50%) for M1 cells based on cell counts and [3H]thymidine incorporation. The replication of M1 cells was also inhibited by lipopolysaccharide (LPS), and as little as 1 unit/ml IL 1 augmented the growth inhibition by LPS. Although IL 1 inhibited M1 cell growth, it did not induce cell differentiation by the criteria of either effect on expression of Fc receptors or on phagocytic ability. However, IL 1 augmented M1 cell differentiation in conjunction with LPS. At low doses of LPS, addition of IL 1 induced differentiation even though LPS and IL 1 by themselves did not induce differentiation. Cells treated with IL 1 for 1 day and then with LPS for an additional 2 days showed considerable augmentation of Fc receptor expression, while cells treated with the same stimuli in the reverse sequence exhibited only a low level of differentiation. Cells treated with medium alone followed by LPS showed moderate increase in Fc receptor expression. In addition, exposure of cells to IL 1 for at least 16 h was required for IL 1 augmenting effect. Therefore, IL 1 appeared to primarily influence M1 cells to become more sensitive to LPS. Treatment with both of IL 1 and LPS induced differentiation of a LPS-resistant clone of M1 cells, and IL 1 pretreatment rendered the resistant clone to become responsive to the differentiation inducing effect of LPS. Culture supernatants of M1 cells after stimulation with LPS contained IL 1-like activity by thymocyte comitogenic assays. In addition, mouse recombinant IL 1 alpha appeared to have the same activity as purified human IL 1 beta on the growth and differentiation of M1 cells. These results suggest that IL 1 may play an important role in mouse myeloid leukemic cell differentiation by acting as an autostimulating factor. IL 1 has been shown to be growth inhibitory and cytocidal for several tumor cell lines. Our results therefore suggest that the effects of IL 1 may result in the induction of terminal differentiation of some tumor cells.
A millimeter wave (18-40 GHz) coaxial and homodyne vector network analyzer (2002)

An 18-40-GHz coaxial six-port reflectometer using four diode detectors is presented. The hardware configuration of the six-port junction as well as the linearization of diode detectors and the calibration of the six-port reflectometer are discussed. Absolute power measurements are not required during linearization of diode detectors. Comparison between experimental results obtained by both the six-port reflectometer and the Wiltron 360 Automatic Network Analyzer on a 3-dB attenuator terminated by a short circuit is presented. The reflectometer exhibits very good performance over the entire frequency band.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Towards Debiasing Sentence Representations (2020)

As natural language processing methods are increasingly deployed in real-world scenarios such as healthcare, legal systems, and social science, it becomes necessary to recognize the role they potentially play in shaping social biases and stereotypes. Previous work has revealed the presence of social biases in widely used word embeddings involving gender, race, religion, and other social constructs. While some methods were proposed to debias these word-level embeddings, there is a need to perform debiasing at the sentence-level given the recent shift towards new contextualized sentence representations such as ELMo and BERT. In this paper, we investigate the presence of social biases in sentence-level representations and propose a new method, SENT-DEBIAS, to reduce these biases. We show that SENT-DEBIAS is effective in removing biases, and at the same time, preserves performance on sentence-level downstream tasks such as sentiment analysis, linguistic acceptability, and natural language understanding. We hope that our work will inspire future research on characterizing and removing social biases from widely adopted sentence representations for fairer NLP.
Structural characterization of lipo‐oligosaccharide (LOS) from Yersinia pestis: regulation of LOS structure by the PhoPQ system (2002)

The two-component regulatory system PhoPQ has been shown to regulate the expression of virulence factors in a number of bacterial species. For one such virulence factor, lipopolysaccharide (LPS), the PhoPQ system has been shown to regulate structural modifications in Salmonella enterica var Typhimurium. In Yersinia pestis, which expresses lipo-oligosaccharide (LOS), a PhoPQ regulatory system has been identified and an isogenic mutant constructed. To investigate potential modifications to LOS from Y. pestis, which to date has not been fully characterized, purified LOS from wild-type plague and the phoP defective mutant were analysed by mass spectrometry. Here we report the structural characterization of LOS from Y. pestis and the direct comparison of LOS from a phoP mutant. Structural modifications to lipid A, the host signalling portion of LOS, were not detected but analysis of the core revealed the expression of two distinct molecular species in wild-type LOS, differing in terminal galactose or heptose. The phoP mutant was restricted to the expression of a single molecular species, containing terminal heptose. The minimum inhibitory concentration of cationic antimicrobial peptides for the two strains was determined and compared with the wild-type: the phoP mutant was highly sensitive to polymyxin. Thus, LOS modification is under the control of the PhoPQ regulatory system and the ability to alter LOS structure may be required for survival of Y. pestis within the mammalian and/or flea host.
High-cut characteristics of the baroreflex neural arc preserve baroreflex gain against pulsatile pressure (2002)

A transfer function from baroreceptor pressure input to sympathetic nerve activity (SNA) shows derivative characteristics in the frequency range below 0.8 Hz in rabbits. These derivative characteristics contribute to a quick and stable arterial pressure (AP) regulation. However, if the derivative characteristics hold up to heart rate frequency, the pulsatile pressure input will yield a markedly augmented SNA signal. Such a signal would saturate the baroreflex signal transduction, thereby disabling the baroreflex regulation of AP. We hypothesized that the transfer gain at heart rate frequency would be much smaller than that predicted from extrapolating the derivative characteristics. In anesthetized rabbits (n = 6), we estimated the neural arc transfer function in the frequency range up to 10 Hz. The transfer gain was lost at a rate of -20 dB/decade when the input frequency exceeded 0.8 Hz. A numerical simulation indicated that the high-cut characteristics above 0.8 Hz were effective to attenuate the pulsatile signal and preserve the open-loop gain when the baroreflex dynamic range was finite.
Sensitive detection of multiple islet autoantibodies in type 1 diabetes using small sample volumes by agglutination-PCR (2020)

Islet autoantibodies are predominantly measured by radioassay to facilitate risk assessment and diagnosis of type 1 diabetes. However, the reliance on radioactive components, large sample volumes and limited throughput renders radioassay testing costly and challenging. We developed a multiplex analysis platform based on antibody detection by agglutination-PCR (ADAP) for the sample-sparing measurement of GAD, IA-2 and insulin autoantibodies/antibodies in 1 μL serum. The assay was developed and validated in 7 distinct cohorts (n = 858) with the majority of the cohorts blinded prior to analysis. Measurements from the ADAP assay were compared to radioassay to determine correlation, concordance, agreement, clinical sensitivity and specificity. The average overall agreement between ADAP and radioassay was above 91%. The average clinical sensitivity and specificity were 96% and 97%. In the IASP 2018 workshop, ADAP achieved the highest sensitivity of all assays tested at 95% specificity (AS95) rating for GAD and IA-2 autoantibodies and top-tier performance for insulin autoantibodies. Furthermore, ADAP correctly identified 95% high-risk individuals with two or more autoantibodies by radioassay amongst 39 relatives of T1D patients tested. In conclusion, the new ADAP assay can reliably detect the three cardinal islet autoantibodies/antibodies in 1μL serum with high sensitivity. This novel assay may improve pediatric testing compliance and facilitate easier community-wide screening for islet autoantibodies.
Improved Precursor Chemistry for the Synthesis of III–V Quantum Dots (2012)

The synthesis of III–V quantum dots has been long known to be more challenging than the synthesis of other types of inorganic quantum dots. This is attributed to highly reactive group-V precursors. We synthesized molecules that are suitable for use as group-V precursors and characterized their reactivity using multiple complementary techniques. We show that the size distribution of indium arsenide quantum dots indeed improves with decreased precursor reactivity.
Left Atrial Blood Stasis and Von Willebrand Factor–ADAMTS13 Homeostasis in Atrial Fibrillation (2011)

The association between VWF and SEC may explain the thrombotic propensity in AF. Elevated VWF:Ag may help identify AF patients at risk for LAAT.