gebhart/patrepeval huggingface dataset:
VennDiagramWeb: a web application for the generation of highly customizable Venn and Euler diagrams (2016)

VennDiagramWeb allows the easy creation of Venn and Euler diagrams for computational biologists, and indeed many other fields. Its ability to support real-time graphics changes that are linked to downloadable code that can be integrated into automated pipelines will greatly facilitate the improved visualization of complex datasets. For application support please contact Paul.Boutros@oicr.on.ca.
An image-based screen identifies a small molecule regulator of megakaryopoiesis (2012)

Molecules that control the lineage commitment of hematopoietic stem cells (HSCs) may allow the expansion of enriched progenitor populations for both research and therapeutic uses. In an effort to better understand and control the differentiation of HSCs to megakaryocytes, we carried out an image-based screen of a library of 50,000 heterocycles using primary human CD34(+) cells. A class of naphthyridinone derivatives was identified that induces the differentiation of common myeloid progenitors (CMP) to megakaryocytes. Kinase profiling and subsequent functional assays revealed that these compounds act through inhibition of platelet-derived growth factor receptor (PDGFR) signaling in CMPs. Such molecules may ultimately have clinical utility in the treatment of thrombocytopenia.
Volumetric MRI differences in treatment-naive vs chronically treated children with ADHD (2006)

The results from this study indicate a relationship of previous treatment history with caudate and anterior cingulate volumetric changes in children with attention deficit hyperactivity disorder-combined type.
Stepped Augmented Glenoid Component in Anatomic Total Shoulder Arthroplasty for B2 and B3 Glenoid Pathology (2021)

Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.
Supplementary Table 1 from Phase I Trial of Adoptive Cell Transfer with Mixed-Profile Type-I/Type-II Allogeneic T Cells for Metastatic Breast Cancer (2023)

&lt;p&gt;PDF file - 24K&lt;/p&gt;
High power 808nm to 1060nm CW and QCW laser diode bars (Conference Presentation) (2019)

We present recent progress of high power 808nm to 1060 nm laser bar operating at both CW and QCW operation. At CW operation, we demonstrate 50FF4.0 mm 940nm to 1060 nm bar can achieve up to 300W output power at 300A with high TE purity on MCCP package. At QCW operation, the 808nm 80FF1.5 mm bar can achieve 600W output power at both 25oC and 75oC on standard CCP; and the 75FF3.0 mm 940nm and 970nm bar can achieve 1KW at 1KA. We will also present results of our 808nm ~ 970nm QCW bar at ns region up to multi KA drive.
Nonlinear Transmission Lines for High Power Microwave Applications - A Survey (2008)

Nonlinear transmission lines (NLTLs) have been used successfully to produce high power microwave (HPM) oscillators over the past 20 years. The advantages of such devices include compact structures in a narrow band radiator, frequency agility, and relatively high power. The key component in such devices is the nonlinear material used in the transmission line (TL). Attempts have been made using both nonlinear dielectrics and magnetic materials in NLTLs, with magnetic materials producing the biggest successes, to-date. This paper presents an overview of the work that has been done to-date in NLTLs with an emphasis on the body of knowledge directly applicable to HPM. A brief summary of the documented efforts using both dielectric and magnetic materials will be offered. Then, the authors present their analysis of what is needed to make further progress along the path towards higher power devices. This paper presents a roadmap for research deemed necessary from an engineering point-of-view to accomplish this goal. In particular, the need for characterizing such materials and building proposed testbeds for accomplishing this goal will be discussed. Finally, we will discuss a third design option - a hybrid approach that combines the features of nonlinear dielectrics and nonlinear magnetic materials for the purpose of producing robust HPM oscillators.
Mutations in exon 3 of the glycogen debranching enzyme gene are associated with glycogen storage disease type III that is differentially expressed in liver and muscle. (1996)

Glycogen storage disease type HI (GSD-III), an autosomal recessive disease, is caused by deficient glycogen debranching enzyme (GDE) activity. Most GSD-III patients are GDE deficient in both liver and muscle (type IIIa), and some GSD-III patients have GDE absent in liver but retained in muscle (type IIIb). The molecular basis for this enzymatic variability is largely unknown. In the present study, the analysis of the GDE gene in three GSD-IIIb patients by single-strand conformation polymorphism (SSCP), DNA sequencing, restriction analysis, and family studies, revealed each of them as being a compound heterozygote for two different mutations. The first mutant alleles in all three patients involved mutations in exon 3 at amino acid codon 6 of the GDE protein. Two had an AG deletion at nucleotides 17 and 18 of the GDE cDNA (17delAG) which resulted in change of subsequent amino acid sequence and a truncated protein (25X); the other had a C to T transition at nucleotide 16 of the cDNA which changed a Glutamine codon to a stop codon (Q6X). The 17delAG mutation was also found in 8 of the 10 additional GSD-IIIb patients. The Q6X mutation was found in one of the remaining two GSD-IIIb patients. These two mutations were not found in any of the 31 GSD-IIIa patients, 2 GSD-IIId patients, nor 28 unrelated normal controls. The second mutant alleles in each of the three GSD-IIIb patients were R864X, R1228X, and W68OX. The R864X and R1228X were not unique for GSD-IIIb as they were also found in GSD-IIIa patients (frequency of 10.3% and 5.2% in Caucasian patients, respectively). Our data demonstrated that both IIIa and IIIb had mutations in the same GDE gene and established for the first time the molecular basis of GSD-III that differentially expressed in liver and muscle. The striking and specific association of exon 3 mutations with GSD-IIIb may provide insight into mechanisms controlling tissue-specific expression of the GDE gene. The identification of exon 3 mutations has clinical significance as well because it distinguished GSD-IIIb from IIIa hence permitting diagnosis from a blood sample rather than a more invasive muscle biopsy.
Figure S3 from A Novel Theranostic Strategy for <i>MMP-14</i>–Expressing Glioblastomas Impacts Survival (2023)

&lt;p&gt;In vivo tumorigenic assay for GIC derived from pcGBM39&lt;/p&gt;
<title>Effect of small silica additions on the properties and structure of calcium aluminate glasses</title> (1990)

Calcium aluminate glasses are transparent to a longer wavelength than silicate gI asses. However it is well known that they are difficult to form into conventional optics due to their high tendency to crystallize. To increase the understanding of aluminate glasses a study of the effect of small silica additions on such properties as viscosity and crystallization tendency has been combined with a study of such optical properties as infrared cut-off and UVVis-NIR spectroscopy. 1.
Synopsis of Mechanical Aging and Fatigue Testing of Llama50 Ink for Direct-Ink-Write 3D Printing (2019)

This document provides a brief synopsis of the results of mechanical aging (thermal and radiation) and fatigue testing of Llama50, an LLNL-made 50A durometer siloxane resin for direct-ink-writing (DIW) with low-temperature capability. Aging studies were performed on both bulk and DIW printed specimens. The fatigue test was performed on DIW printed specimens.
Denmark (1986)

This handbook of international labour market indicators has been compiled to enable easy access to a selection of the key labour market statistics that provide the basis of many cross-national comparisons. It will assist the labour market analyst to focus quickly on relevant information in a selection of industrialized countries. The handbook brings together within a single volume data that is usually only available from a number of different sources, some of them difficult to obtain, with a historical perspective over a ten-year period where the available statistics permit. The use of a long run of data is important, since many of the indicators can be questioned in terms of their validity when taken as absolute values for a single year, a problem which becomes less pronounced when trend analyses are used.
GACETA ILUSTRADA: TALLER DE GRABADO. A CLASES. ANIVERSARIO. VISITA. DIPLOMAS (2004)

GACETA ILUSTRADA PRESENTA: TALLER DE GRABADO. OBRA TERMINADA, EN LA ENAP. - A CLASES. RUMBO A MEDICINA (ALUMNA EN BICICLETA). - ANIVERSARIO. LOS MIEMBROS DE LA GENERACION 1964 DE LA ESCUELA NACIONAL PREPARATORIA NO. 1 COLEGIO DE SAN ILDEFONSO CELEBRARON SU 40 ANIVERSARIO. - VISITA. ELIAS ZERHOUNI, DIRECTOR DE LOS INSTITUTOS NACIONALES DE SALUD DE ESTADOS UNIDOS, VISITO AL RECTOR DE LA UNAM. - DIPLOMAS. CONCLUSION DEL SEMINARIO PR CTICO DE LITIGIO, DIRIGIDO A ALUMNOS DE PRIMER SEMESTRE. FOTOS: JUAN ANTONIO LOPEZ, BENJAMIN CHAIRES, ADRI N HERN NDEZ (DE SERVICIO SOCIAL) Y NARCISO BERNAL.
New tRNA contacts facilitate ligand binding in a Mycobacterium smegmatis T box riboswitch (2018)

T box riboswitches are RNA regulatory elements widely used by organisms in the phyla Firmicutes and Actinobacteria to regulate expression of amino acid-related genes. Expression of T box family genes is down-regulated by transcription attenuation or inhibition of translation initiation in response to increased charging of the cognate tRNA. Three direct contacts with tRNA have been described; however, one of these contacts is absent in a subclass of T box RNAs and the roles of several structural domains conserved in most T box RNAs are unknown. In this study, structural elements of a <i>Mycobacterium smegmatis ileS</i> T box riboswitch variant with an Ultrashort (US) Stem I were sequentially deleted, which resulted in a progressive decrease in binding affinity for the tRNA<sup>Ile</sup> ligand. Selective 2'-hydroxyl acylation analyzed by primer extension (SHAPE) revealed structural changes in conserved riboswitch domains upon interaction with the tRNA ligand. Cross-linking and mutational analyses identified two interaction sites, one between the S-turn element in Stem II and the T arm of tRNA<sup>Ile</sup> and the other between the Stem IIA/B pseudoknot and the D loop of tRNA<sup>Ile</sup> These newly identified RNA contacts add information about tRNA recognition by the T box riboswitch and demonstrate a role for the S-turn and pseudoknot elements, which resemble structural elements that are common in many cellular RNAs.
MT‐II Induces Penile Erection via Brain and Spinal Mechanisms (2003)

alpha-Melanocyte-stimulating hormone induces penile erection via melanocortin (MC) receptors in areas surrounding the third ventricle, but spinal and peripheral mechanisms have not been demonstrated. We used pharmacological strategies to localize the site of the proerectile action of the melanocortin receptor agonist MT-II. We administered MT-II intracerebroventribularly (i.c.v.), intrathecally (i.th.), and intravenously (i.v.) and scored penile erection and yawning for 90 min in awake male rats. In some animals i.c.v. or i.th. SHU-9119 was injected 10 minutes before i.c.v. and i.th. MT-II to confirm the MC receptor action of the agonist and to distinguish spinal from supraspinal effects. To exclude a site of action in the penis, we recorded intracorporal pressure responses to intracavernosal injection of MT-II in the anesthetized rat. MT-II induced penile erections in a dose-dependent fashion, with optimal response at 1 microg for both i.c.v. and i.th. routes. Supraspinal MT-II-induced erections were completely suppressed by 1 microg SHU-9119 i.c.v. Yawning was observed with i.c.v. and i.v. MT-II, whereas spinal injection did not produce this behavior. SHU-9119 blocked the erectile responses to i.th. MT-II when injected i.th. but not i.c.v. Intracavernosal MT-II neither increased intracorporal pressure nor augmented neurostimulated erectile responses. The lumbosacral spinal cord contains MC receptors that can initiate penile erection independent of higher centers. We confirmed the supraspinal proerectile action of MT-II. These results provide insight into the central melanocortinergic pathways that mediate penile erection and may allow for more efficacious melanotropin-based therapy for erectile dysfunction.
Emittance and divergence of laser wakefield accelerated electrons (2010)

We apply the pepper-pot method to measure in a single shot the transverse emittance of quasimonoenergetic electrons with 20 MeV energy produced by laser wakefield acceleration (LWFA). The large divergence of LWFA beams ($&gt;1\text{ }\text{ }\mathrm{mrad}$ typical) compared to conventional rf accelerator beams places additional restrictions on the pepper-pot design. The LWFA beam is found to have a normalized rms transverse emittance of ${ϵ}_{N}=2.3\ensuremath{\pi}\text{ }\text{ }\mathrm{mm}\text{ }\mathrm{mrad}$, with a shot-to-shot fluctuation of 17%. This emittance is comparable to state-of-the-art injectors for conventional linear accelerators. In addition, we examine the beam divergence of LWFA electrons. Simulations and theory indicate that an adiabatic reduction in the beam divergence occurs when the transition region of the downstream plasma density profile is comparable to the betatron period of the electron beam in the plasma accelerator.
An adaptive method for low-delay 360 VR video streaming over HTTP/2 (2018)

Virtually Reality (VR) technology, especially 360 VR videos, is currently a hot topic thanks to its immersive experience, compared to traditional multimedia applications, such as allowing users to experience a close real life by panoramic view. Nevertheless, 360 VR video transmission consumes a huge bandwidth. Besides, how to reduce the delay of 360 VR video streaming is another problem. To address these two challenges, in this paper, we introduce an efficient adaptive 360 VR video streaming method over HTTP/2 using stream priority and stream termination features. To support adaptivity, a 360 VR video is divided into multiple faces and each face is chunked into temporal segments. The video is also stored at the server with different levels of quality. In our method, we focus on the low delay scenario and thus all faces are downloaded simultaneously by using priority feature of HTTP/2 and the client decodes them based on the Group of Pictures (GOP). If the bandwidth suddenly drops, the client will break the simultaneity and inform the server to push consecutively the faces based on their priorities. In addition, stream termination feature can be used to terminate the media parts, which will miss the deadline. The experimental results show that, when the initial buffer is set to 0.5s, there is only 0.08% of the number of GOPs in the front face that miss the deadline in our proposed method, compared to the values of 0.75% and 3.34% of two reference methods.
Crash graphs: An aggregated view of multiple crashes to improve crash triage (2011)

Crash reporting systems play an important role in the overall reliability and dependability of the system helping in identifying and debugging crashes in software systems deployed in the field. In Microsoft for example, the Windows Error Reporting (WER) system receives crash data from users, classifies them, and presents crash information for developers to fix crashes. However, most crash reporting systems deal with crashes individually; they compare crashes individually to classify them, which may cause misclassification. Developers need to download multiple crash data files for debugging, which requires non-trivial effort. In this paper, we propose an approach based on crash graphs, which are an aggregated view of multiple crashes. Our experience with crash graphs indicates that it reduces misclassification and helps identify fixable crashes in advance.
Real-time implementation of discrete wavelet transform for transient type protection applications (2010)

This paper presents the real-time implementation of discrete wavelet transform for transient type protection applications. The multi-resolution properties of wavelet transform makes it efficient for spectral representation of high frequency power system transients. This property is exploited to rapidly detect and accurately classify power network disturbances. This information can then be used for high speed relays that could operate network switches for remedial actions. A digital signal processor platform was used to implement the algorithm. The accuracy of the implementation was verified using MATLAB wavelet toolbox. Example case was presented to demonstrate the applicability of wavelet implementation for transient based protection applications.
Adverse events to Houttuynia injection: A systematic review (2010)

The respiratory system was the most common system treated in Houttuynia injection ADR cases. It was also the most common site of ADR symptoms. The ADRs of Houttuynia injection were serious. The precautions should be taken to prevent the anaphylactic shock. Intravenous injection and the combination with with cephalosporins, penicillins, and macrolides increased the ADR risk of Houttuynia injection.
(Invited) Integration of Germanium Avalanche Photodetectors on Silicon for On-Chip Optical Interconnects (2010)

A waveguide-integrated Germanium avalanche photodetector with gain-bandwidth-product of 350GHz, sensitivity improvement of 6dB, and excess noise with keff ~ 0.2 was demonstrated while operating with 12dB gain at around 3V bias voltage. The photodetector has capacitance of 10+2fF and operates at 40Gbps. Monolithic integration of thin single-crystalline Ge into front end CMOS stack was achieved by rapid melt growth during sourcedrain implant activation anneal.
On the Evolution of Noise in Multiple-Span Transmission With Forward Pumped Raman Amplifiers (2021)

The evolution of noise in transmission systems with multiple spans featuring forward pumped distributed Raman fiber amplifiers has been investigated experimentally and by numerical simulations. We found evidence that the transfer of relative intensity noise from the pump to the signal reveals characteristics of a nonlinear process, which cannot fully be captured by a Gaussian random variable added to the signal power. Power fluctuations of the pump radiation result in an intensity modulation of the amplified signal by stimulated Raman scattering. We have observed that a concatenation of multiple forward pumped amplifiers can lead to an increase of the bandwidth of the noise added to the signal compared to a single amplifier. A process acting like modulation instability of the pump radiation during propagation through the fiber was identified as a potential source of the bandwidth increase from span to span.
Solute Removal by Hollow-Fiber Dialyzers (2007)

Renal replacement therapy performed for end-stage renal disease patients now occurs almost exclusively with hollow-fiber dialyzers. Because renal replacement therapy utilizing such a device requires goals to be set with regard to the rate and extent of solute removal, a thorough understanding of the mechanisms by which solute removal occurs is necessary. This chapter provides an overview of solute removal by hollow-fiber dialyzers. In the fi rst part of the chapter, the major characteristics of hollow-fiber membranes influencing solute removal are discussed. Within this section, the chemical composition and physical characteristics of commonly used dialysis membranes and the features determining their solute permeability properties are reviewed. The remainder of the chapter emphasizes the major determinants of hollow-fiber dialyzer performance.
Analysis of Waste-to-Energy Opportunities in the New York State Food Processing Industry (2011)

Many food processing plants in New York State generate large volume waste streams with a wide variety of physical and chemical properties. With greater environmental regulation and increasing fees for municipal sewer and solid waste disposal, additional innovative ‘disposal’ methods for these wastes need to be developed. One attractive alternative is to use the food processing waste as feedstock for a waste-to-energy conversion process comprising two distinct systems, namely waste-to-fuel and fuel-to-energy. The fuel can either be sold to generate revenue, or converted on-site to electrical or thermal energy to offset the plant power requirements. In this study, the technical viability and economic benefit of applying waste-to-energy solutions to a diverse selection of companies producing milk, cheese, beer, and tofu were assessed. Depending upon the volumes and composition of the available waste streams (including analysis of sugar content, biological oxygen demand, etc.) there may be a compelling business case to utilize the food waste as feedstock for ethanol, biodiesel or methane-rich biogas production.
Structure of the A-DNA Octamer d(GGCATGCC) (1997)

The crystal structure of the self-complementary DNA octamer d(GGCATGCC) has been determined to a resolution of 2.38 A and R factor of 17.1%. The structure is an A-DNA octamer duplex with Watson-Crick base pairing along its length. This sequence extends the investigation of octamer duplexes of the type d(GGX(4)CC) which assume P6(1) packing within the crystallographic unit cell. The A-DNA duplex is non-linear with a helix axis curvature of 7 degrees and bending towards the DNA minor groove. In view of the biological importance of protein recognition of some A-DNA sequences the minor-groove geometry and helix-axis curvature for this structure is compared with all others of the type d(GGXATXCC).
Rapid and selective detection of viruses using virus-imprinted polymer films (2015)

We prepared a nanopatterned polymer film of polydimethylsiloxane (PDMS) via virus imprinting. The imprinted surface exhibited nanoscale cavities with the mean size of 120 ± 4 nm. These cavities demonstrated the ability to preferentially capture a target virus from an aqueous suspension of ultralow volume (5 μL) after only 1 minute of contact. Two inactivated viruses with similar shape, Influenza A (HK68) and Newcastle Disease Virus (NDV), were employed as model pathogens. The polymer film, which was first imprinted with HK68 and exposed sequentially to suspensions containing fluorescently labeled NDV and HK68, was able to preferentially bind HK68 at a capture ratio of 1 : 8.0. When we reversed the procedure and imprinted with NDV, the capture ratio was 1 : 7.6. These results were obtained within 20 minutes of static exposure. The suspensions contained viruses at concentrations close to those occurring physiologically in influenza infections. The limit of detection was approximately 8 fM. Production of virus-imprinted films can be readily scaled to large quantities and yields a disposable, simple-to-use device that allows for rapid detection of viruses.
Blue Gene/L programming and operating environment (2005)

With up to 65,536 compute nodes and a peak performance of more than 360 teraflops, the Blue Gene®/L (BG/L) supercomputer represents a new level of massively parallel systems. The system software stack for BG/L creates a programming and operating environment that harnesses the raw power of this architecture with great effectiveness. The design and implementation of this environment followed three major principles: simplicity, performance, and familiarity. By specializing the services provided by each component of the system architecture, we were able to keep each one simple and leverage the BG/L hardware features to deliver high performance to applications. We also implemented standard programming interfaces and programming languages that greatly simplified the job of porting applications to BG/L. The effectiveness of our approach has been demonstrated by the operational success of several prototype and production machines, which have already been scaled to 16,384 nodes.