gebhart/patrepeval huggingface dataset:
Bioactive refinement for endosaccular treatment of intracranial aneurysms (2021)

Endovascular treatment is the first-line therapy for most intracranial aneurysms; however, recanalisation remains a major limitation. Developments in bioengineering and material science have led to a novel generation of coil technologies for aneurysm embolisation that address clinical challenges of aneurysm recurrence. This review presents an overview of modified surface coil technologies and summarises the state of the art regarding their efficacy and limitations based on experimental and clinical results. We also present potential perspectives to develop biologically optimised devices.
Supplementary Table 1, Figure Legends 1-5 from Transformation-Dependent Silencing of Tumor-Selective Apoptosis-Inducing TRAIL by DNA Hypermethylation Is Antagonized by Decitabine (2023)

Supplementary Table 1, Figure Legends 1-5 from Transformation-Dependent Silencing of Tumor-Selective Apoptosis-Inducing TRAIL by DNA Hypermethylation Is Antagonized by Decitabine
Parity violation in the compound nucleus (1995)

The status of parity violation in the compound nucleus is reviewed. The results of previous experimental results obtained by scattering polarized epithermal neutrons from heavy nuclei in the 3‐p and 4‐p p‐wave strength function peaks are presented. Experimental techniques are presented. The extraction of the mean squared matrix element of the parity‐violating interaction, M2, between compound‐nuclear levels and the relationship of M2 to the coupling strengths in the meson exchange weak nucleon‐nucleon potential are discussed. The tendency of measured asymmetries to have a common sign and theoretical implications are discussed. New experimental results are presented that show that the common sign phenomenon is not universal, as theoretical models developed up to now would predict.
Covalent surface modifications and superconductivity of two-dimensional metal carbide MXenes (2020)

Versatile chemical transformations of surface functional groups in two-dimensional transition-metal carbides (MXenes) open up a previously unexplored design space for this broad class of functional materials. We introduce a general strategy to install and remove surface groups by performing substitution and elimination reactions in molten inorganic salts. Successful synthesis of MXenes with oxygen, imido, sulfur, chlorine, selenium, bromine, and tellurium surface terminations, as well as bare MXenes (no surface termination), was demonstrated. These MXenes show distinctive structural and electronic properties. For example, the surface groups control interatomic distances in the MXene lattice, and Ti <i><sub>n</sub></i> <sub>+1</sub>C <i><sub>n</sub></i> (<i>n</i> = 1, 2) MXenes terminated with telluride (Te<sup>2-</sup>) ligands show a giant (>18%) in-plane lattice expansion compared with the unstrained titanium carbide lattice. The surface groups also control superconductivity of niobium carbide MXenes.
Exploiting free silicon for energy-efficient computing directly in NAND flash-based solid-state storage systems (2013)

Energy consumption is a fundamental issue in today's data centers as data continue growing dramatically. How to process these data in an energy-efficient way becomes more and more important. Prior work had proposed several methods to build an energy-efficient system. The basic idea is to attack the memory wall issue (i.e., the performance gap between CPUs and main memory) by moving computing closer to the data. However, these methods have not been widely adopted due to high cost and limited performance improvements. In this paper, we propose the storage processing unit (SPU) which adds computing power into NAND flash memories at standard solid-state drive (SSD) cost. By pre-processing the data using the SPU, the data that needs to be transferred to host CPUs for further processing are significantly reduced. Simulation results show that the SPU-based system can result in at least 100 times lower energy per operation than a conventional system for data-intensive applications.
<title>High-quality rectangular Y<formula><inf><roman>2</roman></inf></formula>O<formula><inf><roman>3</roman></inf></formula>-ZrO<formula><inf><roman>2</roman></inf></formula> single-crystal optical waveguides for high-temperature fiber optic sensors</title> (2002)

High quality Y<SUB>2</SUB>O<SUB>3</SUB>-ZrO<SUB>2</SUB> single crystal rectangular waveguides had been developed for high-temperature sensing applications. The waveguides were fabricated from bulky Y<SUB>2</SUB>O<SUB>3</SUB> stabilized ZrO<SUB>2</SUB> single crystal by precise cut and fine polish. Three rectangular waveguides with cross-section larger than 1mmx1mm and length of 45mm~65mm were obtained. They showed much better optical properties than Y<SUB>2</SUB>O<SUB>3</SUB>-ZrO<SUB>2</SUB> single crystal fibers grown for fiber-optic sensing in previous work, optical losses of these waveguides were lower than 0.03dB/cm at wavelength of 900nm, and they were able to endure temperature as higher as 2300 degree(s)C. All of them survived a 10g vibration test with average STF(strain to failure) of about 0.25%. Experimental results show that, these waveguides are promising for fiber-optic sensing for temperature above 2000 degree(s)C.
BIODISTRIBUTION OF MONOCLONAL ANTIBODY K1 IN NUDE MICE BEARING HUMAN CARCINOMA XENOGRAFTS EXPRESSING MESOTHELIN (1997)

Hassan, R.; Wu, C.; Brechbiel, M. W.; Margulies, I.; Kreitman, R. J.; Pastan, I. Author Information
Variability in Human Bitter Taste Sensitivity to Chemically Diverse Compounds Can Be Accounted for by Differential TAS2R Activation (2015)

The human population displays high variation in taste perception. Differences in individual taste sensitivity may also impact on nutrient intake and overall appetite. A well-characterized example is the variable perception of bitter compounds such as 6-n-propylthiouracil (PROP) and phenylthiocarbamide (PTC), which can be accounted for at the molecular level by polymorphic variants in the specific type 2 taste receptor (TAS2R38). This phenotypic variation has been associated with influencing dietary preference and other behaviors, although the generalization of PROP/PTC taster status as a predictor of sensitivity to other tastes is controversial. Here, we proposed that the taste sensitivities of different bitter compounds would be correlated only when they activate the same bitter taste receptor. Thirty-four volunteers were exposed to 8 bitter compounds that were selected based on their potential to activate overlapping and distinct repertoires of TAS2Rs. Taste intensity ratings were evaluated using the general Labeled Magnitude Scale. Our data demonstrate a strong interaction between the intensity for bitter substances when they activate common TAS2Rs. Consequently, PROP/PTC sensitivity was not a reliable predictor of general bitter sensitivity. In addition, our findings provide a novel framework to predict taste sensitivity based on their specific T2R activation profile.
Microheaters based on ultrasonic actuation of piezoceramic elements (2011)

This paper describes the use of micromachined lead zirconate titanate (PZT) piezoceramic elements for heat generation by ultrasonic energy dissipated within the elements and surrounding media. Simulations based on three-dimensional finite-element models suggest that circular disk-shaped elements provide superior steady-state temperature rise for a given cross-sectional area, volume of the PZT element and drive voltage. Experimental validation is performed using PZT-5A heaters of 3.2 mm diameter and 0.191 mm thickness. Single-element heaters and dual-element stacks are evaluated. Although the steady-state temperature generated by these heaters reaches the maximum value at the frequency of maximum electromechanical conductance, the heating effectiveness is maximized at the frequency of maximum electromechanical impedance. Stacked PZT heaters provide 3.5 times the temperature rise and 3 times greater heating effectiveness than single elements. Furthermore, the heaters attain the maximum heating effectiveness when bonded to highly damping and non-conducting substrates. A maximum temperature of 120 °C is achieved at 160 mW input power. Experiments are performed using porcine tissue samples to show the feasibility of using PZT heaters in tissue cauterization. A PZT heater probe brands a porcine tissue in 2–3 s with 10 VRMS drive voltage. The interface temperature is ≈150 °C.
AlGaInN laser-diode technology for optical clocks and atom interferometry (2017)

Optical clocks have demonstrated an improvement in temporal accuracy of several orders of magnitude over existing time standards based on caesium. Such systems hold great promise in many industrial sectors including financial time stamping, GPS-free navigation and network synchronisation. Atom interferometry has proven to be a reliable method of precision gravity sensing and finds application in geological studies, including earthquake warning systems and oil exploration. Such systems require a number of sophisticated lasers in a compact and reliable format for use outside of a laboratory environment, suitable for commercialisation and user transportation. Of particular interest, is emerging AlGaInN laser diode technology that has the potential to provide practical solutions for next generation optical clock technology.
Non-endoscopic biopsy techniques: a review (2017)

Diseases of the stomach and small intestine account for approximately 20% of all gastrointestinal (GI)-related mortality. Biopsy of the stomach and small intestine remains a key diagnostic tool for most of the major diseases that affect the GI tract. While endoscopic means for obtaining biopsy is generally the standard of care, it has several limitations that make it less ideal for pediatric patients and in low resource areas of the world. Therefore, non-endoscopic means for obtaining biopsy samples is of interest in these settings. Areas covered: We review non-endoscopic biopsy techniques reported thus far, and critically examine their merits and demerits regarding their suitability for obtaining biopsy samples in non-sedated subjects. Expert commentary: Esophagogastroduodenoscopy (EGD) is the current standard for acquiring biopsy from the GI tract, however, its limitations include subject sedation, expensive endoscopy infrastructure, expert personnel, and a small but significant risk of complications. A less costly, minimally-invasive and non-endoscopic means for obtaining biopsy samples is therefore of interest for addressing these issues. Such a technology would be of significant impact in low- and middle-income countries where conducting endoscopy is challenging.
Evaluation of the Patient for Chemotherapy (2004)

Several important issues must be addressed when any gynecologic cancer patient is being assessed for chemotherapy (see Table 1). The most important question is whether she is a chemotherapy candidate or not. This question is best answered by ﬁrst considering the global health status of the patient, i.e., her physical, psychological, emotional, and quality-of-life status. Next in line for consideration is the therapeutic aim of the proposed treatment. The answers to these questions should be used to weigh the beneﬁts and risks of chemotherapy and whether in fact it should be given. If cure is the therapeutic aim, then considerable short-term toxicity, as produced by intensive combination chemotherapy, is likely to be acceptable. Where short-term palliation is the aim, few, if any, side eﬀects are acceptable. It must also be remembered that what is achievable can change as the disease evolves. Initial therapymay be aimed at obtaining a cure, but for most gynecologic malignancies, if relapse occurs, cure is not possible, although further chemotherapy may achieve temporary remission and may be indicated. Similarly, second-line chemotherapy may achieve a worthwhile remission in a patient who has had a long remission following ﬁrst-line therapy. In general, however, when gynecologic cancer patients prove resistant to ﬁrst-line chemotherapy, they are unlikely to respond to second-line therapy. In such a setting, second-line chemotherapy should therefore be considered experimental, with major toxicity being unacceptable.
Insulin Antagonist of Pituitary Origin in Plasma of Normal and Diabetic Subjects (1971)

Studies on ultrafiltrates of the plasma of normal and diabetic subjects have shown that a polypeptide of similar characteristics to the growth-hormone-derived polypeptide In-G is present in higher concentrations in diabetic subjects, thus indicating a possible role in the pathogenesis of diabetes mellitus. The polypeptide is absent from the plasma of hypophysectomized diabetic patients.
On Adversarial Removal of Hypothesis-only Bias in Natural Language\n Inference (2019)

Popular Natural Language Inference (NLI) datasets have been shown to be\ntainted by hypothesis-only biases. Adversarial learning may help models ignore\nsensitive biases and spurious correlations in data. We evaluate whether\nadversarial learning can be used in NLI to encourage models to learn\nrepresentations free of hypothesis-only biases. Our analyses indicate that the\nrepresentations learned via adversarial learning may be less biased, with only\nsmall drops in NLI accuracy.\n
Berichtigung: Induced‐Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target (2010)

In den Hintergrundinformationen zu dieser Zuschrift (DOI: ) sind für die Genotypen 1 a und 1 b falsche Uniprot-Zugangscodes angegeben. Die korrekten Codes lauten B1PBR5_9HEPC (1 a) und P90191_9HEPC (1 b).
Using an Integrated Silicon Emitter to Generate Two Coaxial Orbital-Angular-Momentum Beams with Tunable Mode Orders and Broad Bandwidth (2019)

We design and simulate a broadband integrated silicon emitter to generate two coaxial orbital-angular-momentum beams with tunable mode orders (ℓ = {-1,0} or {0,+1}). Crosstalk &lt;-15 dB is achieved over 1500-1600 nm.
Duplication Mechanism and Disruptions in Flanking Regions Determine the Fate of Mammalian Gene Duplicates (2009)

Here we identify duplicated genes in five mammalian genomes and classify these duplicates based on the mechanisms by which they were generated. Retrotransposition accounts for at least half of all predicted duplicate genes in these genomes, with tandem and interspersed DNA-mediated duplicates comprising the other half. Estimation of the evolutionary rates in each class revealed greater rate asymmetry between retrotransposed and interspersed DNA duplicate pairs than between tandem duplicates, suggesting that retrotransposed and interspersed DNA duplicates are diverging more quickly. In an attempt to understand the basis of this asymmetry, we identified disruption of flanking DNA as an indicator of new duplicate fate-loss of local synteny accelerates the asymmetry of divergence of interspersed DNA duplicates. We also show that intact retrogenes are enriched in intergenic regions and indel purified regions of the human genome. Moreover, intact retrogenes closest to annotated genes show the greatest levels of purifying selective pressure. Together, these findings suggest that the differential evolution of duplicate genes may be significantly influenced by changes in local genome architecture.
Periodontal tissue regeneration by combined applications of recombinant human osteogenic protein‐1 and bone morphogenetic protein‐2. A pilot study in Chacma baboons (Papio ursinus) (2001)

Native and recombinant human bone morphogenetic/osteogenic proteins (BMPs/ OPs) singly initiate bone induction in vivo. The finding of synchronous but spatially different BMPs/OPs expression during periodontal tissue morphogenesis suggests novel therapeutic approaches using morphogen combinations based on recapitulation of embryonic development. Twelve furcation defects prepared in the first and second mandibular molars of three adult baboons (Papio ursinus) were used to assess whether qualitative histological aspects of periodontal tissue regeneration could be enhanced and tissue morphogenesis modified by combined or single applications of recombinant hOP-1 and hBMP-2. Doses of BMPs/OPs were 100 microg of each protein per 1 g of insoluble collagenous bone matrix as carrier. Approximately 200 mg of carrier matrix was used per furcation defect. Undecalcified sections cut for histological analysis 60 d after healing of hOP-1-treated specimens showed substantial cementogenesis with scattered remnants of the collagenous carrier. hBMP-2 applied alone induced greater amounts of mineralized bone and osteoid when compared to hOP-1 alone or to combined morphogen applications. Combined applications of hOP-1 and hBMP-2 did not enhance alveolar bone regeneration or new attachment formation over and above the single applications of the morphogens. The results of this study, which is the first to attempt to address the structure-activity relationship amongst BMP/OP family members, indicate that tissue morphogenesis induced by hOP-1 and hBMP-2 is qualitatively different when the morphogens are applied singly, with hOP-1 inducing substantial cementogenesis. hBMP-2 treated defects, on the other hand, showed limited cementum formation but a temporal enhancement of alveolar bone regeneration and remodelling. The demonstration of therapeutic mosaicism in periodontal regeneration will require extensive testing of ratios and doses of recombinant morphogen combinations for optimal tissue engineering in clinical contexts.
Julio Victor Iribarne, November 11, 1916–November 15, 2012 (2013)

ADVERTISEMENT RETURN TO ISSUEPREVObituaryJulio Victor Iribarne, November 11, 1916–November 15, 2012Bruce ThomsonBruce ThomsonAB Sciex, L4K 4V8, Concord, Ontario, CanadaMore by Bruce ThomsonCite this: J. Am. Soc. Mass Spectrom. 2013, 24, 2, 313Publication Date (Web):January 25, 2013Publication History Published online25 January 2013Published inissue 1 February 2013https://pubs.acs.org/doi/10.1007/s13361-012-0557-xhttps://doi.org/10.1007/s13361-012-0557-xresearch-articleACS PublicationsCopyright © 2013 © American Society for Mass Spectrometry 2013Request reuse permissionsArticle Views4Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Cloning and expression of rat 25-hydroxyvitamin D 3 -1α-hydroxylase cDNA (1997)

A full-length cDNA for the rat kidney mitochondrial cytochrome P450 mixed function oxidase, 25-hydroxyvitamin D3-1alpha-hydroxylase (P4501alpha), was cloned from a vitamin D-deficient rat kidney cDNA library and subcloned into the mammalian expression vector pcDNA 3.1(+). When P4501alpha cDNA was transfected into COS-7 transformed monkey kidney cells, they expressed 25-hydroxyvitamin D3-1alpha-hydroxylase activity. The sequence analysis showed that P4501alpha was of 2,469 bp long and contained an ORF encoding 501 amino acids. The deduced amino acid sequence showed a 53% similarity and 44% identity to the vitamin D3-25-hydroxylase (CYP27), whereas it has 42.6% similarity and 34% identity with the 25-hydroxyvitamin D3-24-hydroxylase (CYP24). Thus, it composes a new subfamily of the CYP27 family. Further, it is more closely related to the CYP27 than to the CYP24. The expression of P4501alpha mRNA was greatly increased in the kidney of vitamin D-deficient rats. In rats with the enhanced renal production of 1alpha,25-dihydroxyvitamin D3 (rats fed a low Ca diet), P4501alpha mRNA was greatly increased in the renal proximal convoluted tubules.
Transforming the prostatic tumor microenvironment with oncolytic virotherapy (2018)

Prostate cancer (PCa) was estimated to have the second highest global incidence rate for male non-skin tumors and is the fifth most deadly in men thus mandating the need for novel treatment options. MG1-Maraba is a potent and versatile oncolytic virus capable of lethally infecting a variety of prostatic tumor cell lines alongside primary PCa biopsies and exerts direct oncolytic effects against large TRAMP-C2 tumors <i>in vivo</i>. An oncolytic immunotherapeutic strategy utilizing a priming vaccine and intravenously administered MG1-Maraba both expressing the human six-transmembrane antigen of the prostate (STEAP) protein generated specific CD8+ T-cell responses against multiple STEAP epitopes and resulted in functional breach of tolerance. Treatment of mice with bulky TRAMP-C2 tumors using oncolytic STEAP immunotherapy induced an overt delay in tumor progression, marked intratumoral lymphocytic infiltration with an active transcriptional profile and up-regulation of MHC class I. The preclinical data generated here offers clear rationale for clinically evaluating this approach for men with advanced PCa.
Outcomes Among Patients With 1-Year Survival After Intensive Care Unit Treatment for COVID-19 (2022)

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