gebhart/patrepeval huggingface dataset:
A New Antimicrobial Antibiotic from Actinoplanes capillaceus sp. K95-5561T. (2000)

In our ongoing search for novel biologically active metabolites from rare actinomycetes, an antibiotic 2hydroxyethyl-3-methyl-1,4-naphthoquinone (1, Fig. This is the first report that 1 was isolated from natural source. Herein, we report the fermentation, isolation and biological activity of 1.
Table S2 from PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8<sup>+</sup> T-Cell–Driven Antitumor Immunity (2023)

&lt;p&gt;List of genes in clusters 3 and 4 with the greatest fold-changes between monotherapy and combination therapy groups&lt;/p&gt;
Immunologic Characterization of a Rhesus Macaque H1N1 Challenge Model for Candidate Influenza Virus Vaccine Assessment (2014)

Despite the availability of annually formulated vaccines, influenza virus infection remains a worldwide public health burden. Therefore, it is important to develop preclinical challenge models that enable the evaluation of vaccine candidates while elucidating mechanisms of protection. Here, we report that naive rhesus macaques challenged with 2009 pandemic H1N1 (pH1N1) influenza virus do not develop observable clinical symptoms of disease but develop a subclinical biphasic fever on days 1 and 5 to 6 postchallenge. Whole blood microarray analysis further revealed that interferon activity was associated with fever. We then tested whether type I interferon activity in the blood is a correlate of vaccine efficacy. The animals immunized with candidate vaccines carrying hemagglutinin (HA) or nucleoprotein (NP) exhibited significantly reduced interferon activity on days 5 to 6 postchallenge. Supported by cellular and serological data, we conclude that blood interferon activity is a prominent marker that provides a convenient metric of influenza virus vaccine efficacy in the subclinical rhesus macaque model.
0351 Towards Interpreting Consumer Sleep Data: Distributions of Sleep Scores (2022)

Abstract Introduction With the rise of sleep measurement technology becoming widely available to the public, it has become apparent that traditional sleep metrics might not be best suited for a lay audience. Most consumer industry has started including a metric that would capture sleep quality, although the exact calculations of these scores remain proprietary. These novel outcome metrics require a set of reference values in order to become interpretable. Here, we provide reference values for the parameters SleepScore, BodyScore and MindScore as included in the SleepScore Labs non-contact radiofrequency sleep measurement devices. Methods SleepScore is a sleep quality metric that includes objectively measured total sleep time (TST), sleep onset latency (SOL) and sleep stage durations, normalized for aged and sex, using reference values of Ohayon et al (2004), ranging from 0-100. BodyScore reflects the normalized amount of deep sleep, whereas MindScore reflects the normalized amount of REM, ranging from 0-100. Data from 40,862 S+ and Max users between 18 and 98 years old were used to calculate distribution statistics. Results The average age of users was 53±15 years old. Individual scores of SleepScore, BodyScore and MindScore ranged from 0-100 and their distribution was left-skewed. SleepScore averaged 81±11, with the first quartile (Q1) at 73, median at 81 and third quartile (Q3) at 88, and a mode of 89. BodyScore averaged 81±10 with Q1 at 73, median at 80 and Q3 at 86, and a mode of 84. MindScore averaged 78±10 with Q1 at 72, median at 79 and Q3 at 84, and a mode of 83. Despite being algorithmically normalized for age, average SleepScore increased from 70 to 88 across the age range, BodyScore increased from 71 to 89, and MindScore increased from 75 to 81. Conclusion SleepScores, BodyScores and MindScores presented to the average consumer will mostly show them a number in the low 70 to high 80 range. This distribution was intentionally created as being left-skewed to prevent triggering anxiety that may contribute to orthosomnia. Despite the intent to create a normalized score that would not be impacted by age, the data show an increase of scores by age. Support (If Any)
ATOMIZATION CHARACTERISTICS OF AIRBLAST FUEL INJECTION INSIDE A VENTURI TUBE (1997)

This article describes the experimental and numerical characterization of capillary fuel injection, atomization, and dispersion of liquid fuel in a co-flowing air stream inside a single venturi tube. The experimental techniques used are all laser-based. A phase Doppler particle analyzer (PDPA) was used to characterize the atomization process, and planar laser-induced fluorescence (PLIF) was used to visualize the breakup and atomization process of the capillary fuel spray. The PLIF experiments confirmed the domination of aerodynamic breakup mechanism in and the influence of gaseous vortical structures of various scales on the atomization process of capillary fuel spray. The PLIF images displayed a smooth liquid jet surface near the fuel tube exit, with a rough, perturbed surface developing gradually. At low relative velocities, it was observed that the initial dilational waves on the jet surface were followed by asymmetric and sinuous waves before they evolved into curling liquid ligaments and/or droplets, as the relative velocities increased. The advantages of venturi nozzle are demonstrated in this article in terms of better atomization, more uniform fuelair distribution, compared with straight-tube nozzles and free jets. A modified version of KIVA-II was used to simulate the entire spray process, including breakup and atomization. It was concluded that the multidimensional spray calculation can be used as a design tool only if care is taken in the modeling of breakup and wall impingement processes.
Finding links and initiators: a graph-reconstruction problem (2009)

Consider a 0-1 observation matrix M , where rows correspond to entities and columns correspond to signals; a value of 1 (or 0) in cell (i, j) of M indicates that signal j has been observed (or not observed) in entity i. Given such a matrix we study the problem of inferring the underlying directed links between entities (rows) and finding which entries in the matrix are initiators.
<title>Design and operation of the Compact Infrared Free-Electron Laser (CIRFEL)</title> (1995)

The Compact Infrared Free Electron Laser (CIRFEL) was built as part of a joint collaboration between Northrop Grumman and Princeton University to develop FEL's for use by researchers in the materials, medical and physical sciences. The CIRFEL was designed to laser in the Mid-IR and Far-IR regimes with picosecond pulses, megawatt level peak powers and an average power of a few watts. The CIRFEL utilizes an RF photocathode gun to produce high-brightness time synchronized electron bunches. The micropulse separation is 7 nsec which allows a number of relaxation phenomena to be observed. In addition, the photocathode illumination laser can be used in combination with the FEL IR light for pump- probe experiments. The CIRFEL is presently being commissioned and working towards lasing. The present status of the machine is presented.
p-Sulfonatocalix[4]arene binding of monovalent, divalent and trivalent metal ions (2020)

Structural studies on p-sulfonatocalix[4]arene coordination compounds involving diverse metal ions with respect to their size and charge, caesium(I), copper(II) and neodymium(III) are reported. The metal coordination-driven self-assembly forms metallosupramolecules, either as a two-dimensional (2 D) or a three-dimensional (3D) network while retaining the commonly established bilayer array for p-sulfonatocalix[4]arene. The complex (Cs5-p-sulfonatocalix[4]arene-H+)·6H2O has five crystallographically independent caesium(I) ions with high coordination numbers. In the divalent complex {[Cu3(H2O)12-2(p-sulfonatocalix[4]arene)]2-}·2([Cu(H2O)5])2+·2NO3-·7H2O, two different copper(II) coordination environments are present, one with octahedral stereochemistry while bridging two opposing calixarenes with the other having a square pyramidal geometry involving one sulfonate group. Eight-coordinate neodymium(III) metal ions prevail in Nd0.25(H2O)1.25(p-sulfonatocalix[4]arene + H+)0.25, involving four sulfonate groups from four different calixarenes.
Synthesis and Activity of C11-Modified Wortmannin Probes for PI3 Kinase (2005)

The key role played by PI3 kinase in cancer, hormone action, and a host of other biological functions suggests that specific inhibitors whose disposition could be ascertained in vivo would be useful in biological research or, potentially, for imaging PI3K in a clinical setting. Wortmannin (Wm, 1) is an inhibitor of PI3 kinase with high specificity for this enzyme. We synthesized three modified Wm probes, a biotinylated Wm (7a), a 4-hydroxy-3-iodophenylated Wm, which was obtained both unlabeled (7b) and labeled with (125)I (8), and a fluoresceinated Wm (7c), through modification at C-11, and evaluated their inhibitive activity as inhibitors of PI3 kinase. Biotinylated (7a) and 4-hydroxy-3-iodophenylated Wm's (7b) had IC(50)s for PI3K of 6.11 and 11.02 nM, respectively, compared to an IC(50) for Wm of 1.63 nM. Fluoresceinated Wm (7c) lost considerably more activity than the other derivatives, with an IC(50) of 64.9 nM. The (125)I labeled 4-hydroxy-3-iodophenylated Wm (8) could be detected after reaction with an immunoprecipitate of PI3 kinase. The activity of these reporter Wm's is discussed in relationship to earlier findings on the pharmacological activity of Wm derivatives and the ability of inhibitors to fit into the ATP pocket of PI3 kinase.
Cyclopamine–Paclitaxel‐Containing Nanoparticles: Internalization in Cells Detected by Confocal and Super‐Resolution Microscopy (2015)

Cyclopamine- and paclitaxel-containing hetero-nanoparticles generated by self-assembly show combined efficacy in the treatment of three different cancer cell lines. The use of ternary combination with the addition of a dye-squalene conjugate secured the obtainment of fluorescent nanoparticles that permitted the observation of the cellular internalization by confocal microscopy and super-resolution dSTORM (direct stochastic optical reconstruction microscopy).
Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry-Based Functional Assay for Rapid Detection of Resistance against β-Lactam Antibiotics (2011)

Resistance against β-lactam antibiotics is a growing challenge for managing severe bacterial infections. The rapid and cost-efficient determination of β-lactam resistance is an important prerequisite for the choice of an adequate antibiotic therapy. β-Lactam resistance is based mainly on the expression/overexpression of β-lactamases, which destroy the central β-lactam ring of these drugs by hydrolysis. Hydrolysis corresponds to a mass shift of +18 Da, which can be easily detected by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). Therefore, a MALDI-TOF MS-based assay was set up to investigate different enterobacteria for resistance against different β-lactam antibiotics: ampicillin, piperacillin, cefotaxime, ceftazidime, ertapenem, imipenem, and meropenem. β-Lactamases are enzymes that have a high turnover rate. Therefore, hydrolysis can be detected by MALDI-TOF MS already after a few hours of incubation of the bacteria to be tested with the given antibiotic. The comparison of the MS-derived data with the data from the routine procedure revealed identical classification of the bacteria according to sensitivity and resistance. The MALDI-TOF MS-based assay delivers the results on the same day. The approved routine procedures require at least an additional overnight incubation.
Experimental comparison between optimized fiber Bragg grating and delay-line interferometer for DPSK signal demodulation (2008)

10 Gb/s DPSK demodulation effectiveness of a suitably-designed FBG structure is compared with the performance achieved by a compact integrated-optic MZDI. BER measures versus operation stability are reported.
Meshless Methods for Full Field Displacement and Strain Measurement (2014)

Over the last decade, full field measurement methods have become a very useful tool for experimental mechanics and other technical disciplines. The rapid evolution of digital imaging, that has materialized toward higher quality, more inexpensive digital cameras, and the increase in the available computational power, have made these methods accessible to a broader range of scientific laboratories. Our interest in the continuing development of meshless methods for full field measurements originates from the need to improve, generalize and integrate them into the data-driven composite material characterization methodology via multi-axial mechatronic systems that were developed by the Naval Research Laboratory (NRL). This methodology requires the measurement of both in-plane and out-of-plane strain fields, and therefore such methods are particularly attractive for this purpose. In addition, there is a large variety of applications in the area of experimental mechanics and other technical disciplines where the whole field displacement and strain measurement is very important, and consequently provide a unique opportunity for the usage of the meshless approximation schemes. In engineering applications traditional approximation schemes involve the use of discrete elements corresponding to typical meshes for representing field variable distributions. More specifically, the underlying geometry is subdivided into a number of sub-regions of simple geometry, usually in the shape of a triangle or quadrilateral. The values of the field quantities of interest within these subregions or elements can be calculated based on assumed shape functions of the respective elements. In meshless approaches such sub-regions are not defined and the values of the field variable are calculated based on shape functions operating on nodal values only. All the traditional full field measurement techniques are based on shape functions associated with element approaches. This chapter is motivated by the need to report on the advances related to the use of meshless approximations in full field displacement and strain measurements. These approximations were first introduced in [1] and were shown to be a very efficient way to increase the accuracy of these methods by taking advantage of the filtering characteristics of the representation. The method wasmore recently updated with a direct strain approximation scheme that increases the accuracy even further [2]. The goal of this chapter is to present the older meshless random grid method (MRG) and the newer direct strain imaging (DSI) methods, while comparing their performance and reporting on implementation details, like their 3-D extension.
Screening of Panamanian Plants for Cosmetic Properties, and HPLC-Based Identification of Constituents with Antioxidant and UV-B Protecting Activities (2015)

A library of 600 taxonomically diverse Panamanian plant extracts was screened for DPPH scavenging and UV-B protective activities, and the methanolic extracts of Mosquitoxylum jamaicense, Combretum cacoucia, and Casearia commersionia were submitted to HPLC-based activity profiling. The compounds located in the active time windows were isolated and identified as gallic acid derivatives and flavonoids. Gallic acid methyl ester (3) and digallic acid derivatives (2, 6) showed the highest DPPH scavenging activity (<10 μg/mL), while protocatechuic acid (7) and isoquercitrin (10) exhibited the highest UV-B protective properties.
INCREASING SEED YIELD IN GLORY LILY (GLORIOSA SUPERBA) - EXPERIMENTAL APPROACHES (1999)

ISHS II WOCMAP Congress Medicinal and Aromatic Plants, Part 3: Agricultural Production, Post Harvest Techniques, Biotechnology INCREASING SEED YIELD IN GLORY LILY (GLORIOSA SUPERBA) - EXPERIMENTAL APPROACHES
Substance P Receptor-dependent Responses of Leukocytes in Pulmonary Inflammation (1987)

Pulmonary immunologic responses may be mediated and modulated in part by neuropeptides released from the endings of nerve fibers that innervate the airways. Bronchoconstriction, mucosal edema, and increased airway secretions may be mediated by multiple locally generated neuropeptides. The neuropeptides affect directly and indirectly through other mediators the functions of endothelial cells, smooth muscle cells, blood vessels, and leukocytes. The high content of diverse potent neuropeptides in the ganglionated plexuses close to pulmonary smooth muscle bundles, along blood vessels, and in neural projections into the bronchial epithelium and regions containing acini of mucus glands provide tissue concentrations well within the range required to attain such biologic effects. The airway responses mediated principally by neuropeptides exhibit unique mechanisms of specificity attributable to the selective distribution of each neuropeptide in a distinct subset of nerve fibers that react differently to each stimulus and to the target cell specificity of the neuropeptides. At physiologically relevant in vitro concentrations, many of the neuropeptides have different effects on mast cells, basophils, monocytes, and lymphocytes. The direct actions of substance P (SP) and the capacity to initiate and modulate leukocyte responses are described in relation to the physiologic and pathopharmacologic consequences of pulmonary nerve stimulation. Selected cellular and molecular characteristics of the interactions of SP with mast cells, basophils, lymphocytes, endothelial cells, and smooth muscle cells also will be presented in order to define the functionally critical properties of receptors for the neuropeptide and to expose possible means of specifically modifying the interactions.
Small Molecule Control of Morpholino Antisense Oligonucleotide Function through Staudinger Reduction (2021)

Conditionally activated, caged morpholino antisense agents (cMOs) are tools that enable the temporal and spatial investigation of gene expression, regulation, and function during embryonic development. Cyclic MOs are conformationally gated oligonucleotide analogs that do not block gene expression until they are linearized through the application of an external trigger, such as light or enzyme activity. Here, we describe the first examples of small molecule-responsive cMOs, which undergo rapid and efficient decaging via a Staudinger reduction. This is enabled by a highly flexible linker design that offers opportunities for the installation of chemically activated, self-immolative motifs. We synthesized cyclic cMOs against two distinct, developmentally relevant genes and demonstrated phosphine-triggered knockdown of gene expression in zebrafish embryos. This represents the first report of a small molecule-triggered antisense agent for gene knockdown, adding another bioorthogonal entry to the growing arsenal of gene knockdown tools.
Towards Conversational Speech Recognition for a Wearable Computer Based Appointment Scheduling Agent (2002)

We present an original study of current mobile appointment scheduling devices. Our intention is to create a conversational wearable computing interface for the task of appointment scheduling. We employ both survey questionnaires and timing tests of mock scheduling tasks. The study includes over 150 participants and times each person using his or her own scheduling device (e.g., a paper planner or personal digital assistant). Our tests show that current scheduling devices take a surprisingly long time to access and that our subjects often do not use the primary scheduling device claimed on the questionnaire. Slower devices (e.g., PDAs) are disproportionately abandoned in favor of devices with faster access times (e.g., scrap paper). Many subjects indicate that they use a faster device when mobile as a buffer until they can reconcile the data with their primary scheduling device.&#13;\n&#13;\nThe findings of this study motivated the design of two conversational speech systems for everyday--use wearable computers. The Calendar Navigator Agent provides extremely fast access to the user's calendar through a wearable computer with a head-up display. The user's verbal negotiation for a meeting time is monitored by the wearable which provides an appropriate calendar display based on the current conversation. The second system, now under development, attempts to minimize cognitive load by buffering and indexing appointment conversations for later processing by the user. Both systems use extreme restrictions to decrease speech recognition error rates, yet are designed to be socially graceful.
Required traction during common rugby movements (2019)

Rugby is one of the most popular sports in the world, ranking third among contact sports (Kaplan, Goodwillie, Strauss, & Rosen, 2008). Despite rugby’s widespread popularity, rugby boot design, unli...
O 2 ‐reduction at high temperature: MCFC (2010)

Abstract Oxygen reduction in molten carbonate is discussed in relation to the molten carbonate fuel cell. The melt chemistry of molten carbonate is found to be crucial in understanding the possible reaction mechanism and the dissolution problems of the cathode. Using concepts form linear algebra a complete set of equilibria describing the melt is constructed, which is used to derive the relative concentrations of species in the melt and possible reaction mechanisms. Experimental results are critically reviewed in the light of the theoretical predictions. Based on the obtained insight in the fundamental processes, research directions are indicated for minimizing cathode dissolution and cathode polarization, including a radical new concept of a MCFC with a separate CO 2 channel.
Substituted [(4-Phenylpiperazinyl)- methyl]benzamides:  Selective Dopamine D4 Agonists (1997)

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTSubstituted [(4-Phenylpiperazinyl)- methyl]benzamides: Selective Dopamine D4 AgonistsShelly A. Glase, Hyacinth C. Akunne, Lynn M. Georgic, Thomas G. Heffner, Robert G. MacKenzie, Peter J. Manley, Thomas A. Pugsley, and Lawrence D. WiseView Author Information Departments of Chemistry and Therapeutics, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, Michigan 48105Cite this: J. Med. Chem. 1997, 40, 12, 1771–1772Publication Date (Web):June 6, 1997Publication History Received10 January 1997Published online6 June 1997Published inissue 1 June 1997https://pubs.acs.org/doi/10.1021/jm970021chttps://doi.org/10.1021/jm970021crapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views611Altmetric-Citations93LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Agonists,Amines,Organic reactions,Receptors,Selectivity Get e-Alerts