gebhart/patrepeval huggingface dataset:
Figure S1-S5 and Table S1 from Activating an Adaptive Immune Response with a Telomerase-Mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma (2023)

&lt;p&gt;Supplementary Figure Legends&lt;/p&gt;
<title>Clinical applications of dynamic optical tomography in vascular disease</title> (2001)

Vascular disease is a significant source of mortality and morbidity for many patient populations. While substantial strides in surgical therapeutics have been made in the past decade, our limited understanding of the microvascular processes, which are invisible to conventional imaging modalities and beyond the scope of our current physiologic paradigms, has slowed the advancement of medical therapeutic interventions. In this report we present data in support of an emerging body of work demonstrating that the method of dynamic optical tomography can yield critical insights into the underpinnings of microvascular pathophysiology in large tissue structures.
The Limits of The Subject in Badiou's Being and Event (2006)

This essay is an examination of the limits of the model of the subject that Badiou establishes in emBeing and Event/em. This will concentrate on both emBeing and Event/em, and the later ethical developments introduced in emEthics: An Essay on the Understanding of Evil/em. My aim will be to show that there is a possible subjective figure, based on the independence of the Axiom of Choice, which remains unexamined in both these works. The introduction of this new subjective figure not only complicates Badioursquo;s ethical categories of Good and Evil, but it also raises questions about the nature of the subject in general in his philosophy.
Quadrature-Phase-Shift-Keying Radio-over-Fiber Transmission for Coherent Optical and Radio Seamless Networks (2013)

We propose a coherent optical and radio seamless network concept that allows broadband access without deployment of additional optical fibers within an optical fiber dead zone while enhancing network resilience to disasters. Recently developed radio-over-fiber (RoF) and digital coherent detection technologies can seamlessly convert between optical and radio signals. A millimeter-wave radio with a capacity greater than 10Gb/s and high-speed digital signal processing is feasible for this purpose. We provide a preliminary demonstration of a high-speed, W-band (75-110GHz) radio that is seamlessly connected to an optical RoF transmitter using a highly accurate optical modulation technique to stabilize the center frequencies of radio signals. Using a W-band digital receiver with a sensitivity of -37dBm, we successfully transmitted an 18.6Gb/s quadrature-phase-shift-keying signal through both air and an optical fiber.
Dielectric phantom materials for broadband biomedical applications (2017)

In this contribution, we present broadband microwave measurements on developed biomedical phantom materials. Therefore, we illustrate the reproducible mixing process of the realized phantom materials that are generated in different shapes with a potting compound and barium titanate. Moreover, three microwave measurement systems, including a coaxial probe, a microwave tomography system, and a radar ellipsometry system, characterize the dielectric behavior of the samples in different frequency bands.
Mitigation of antenna displacement with array antenna for data transmission in wireless power transfer system (2015)

Magnetic resonance wireless power transfer is expected to be one of the prevalent schemes because of its high efficiency and long transmission range. However, in this scheme, there is a problem that the characteristics of a transmission channel changes in according with the distance between coil antennas. This paper investigates the performance of data transmission with an array antenna in a wireless power transfer system. In the assumed system, the same antennas for wireless power transfer are used for data transmission. The frequency response of the channel for data transmission changes in according with the distance between the antennas. The assumed system uses multiple transmit antennas and beamforming is realized with ideal phase shifts to transmit symbols in the transmitter. Numerical results obtained through computer simulation show that the proposed scheme can mitigate the dependency of the bit error rate (BER) to the distance between the antennas. It is within 1-3 dB at the BER of 10-5 with two transmit antennas. In addition, the system with two transmit antennas achieves 2 dB or more improvement in term of the BER than with a single antenna for specific antenna distances.
Validation of a New NIRS Method for Measuring Muscle Oxygenation during Rhythmic Handgrip Exercise (2006)

Near infrared spectroscopy (NIRS) is commonly used to measure muscle oxygenation during exercise and recovery. Current NIRS algorithms do not account for variation in water content and optical pathlength during exercise. The current effort attempts to validate a newly developed NIRS algorithm during rhythmic handgrip exercise and recovery. Six female subjects, aver age 28 +/- 6 yrs, participated in the study. A venous catheter was placed in the retrograde direction in the antecubital space. A NIRS sensor with 30 mm source-detector separation was placed on the flexor digitorum profundus. Subjects performed two 5-min bouts of rhythmic handgrip exercise (2 s contraction/1 s relaxation) at 15% and 30% of maximal voluntary contraction. Venous blood was sampled before each bout, during the last minute of exercise, and after 5 minutes of recovery. Venous oxygen saturation (SvO2) was measured with a I-stat CG-4+ cartridge. Spectra were collected between 700-900 nm. A modified Beer's Law formula was used to calculate the absolute concentration of oxyhemoglobin (HbO2), deoxyhemoglobin (Hb) and water, as well as effective pathlength for each spectrum. Muscle oxygen saturation (SmO2) was calculated from the HbO2 and Hb results. The correlation between SvO2 and SmO2 was determined. Optical pathlength and water varied significantly during each exercise bout, with pathlength increasing approximately 20% and water increasing about 2%. R2 between blood and muscle SO2 was found to be 0.74, the figure shows the relationship over SvO2 values between 22% and 82%. The NIRS measurement was, on average, 6% lower than the blood measurement. It was concluded that pathlength changes during exercise because muscle contraction causes variation in optical scattering. Water concentration also changes, but only slightly. A new NIRS algorithm which accounts for exercise-induced variation in water and pathlength provided an accurate assessment of muscle oxygen saturation before, during and after exercise.
ChemInform Abstract: Organolanthanoid‐Catalyzed Carbon‐Heteroatom Bond Formation. Observations on the Facile, Regiospecific Cyclization of Aminoalkynes. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplemental figure 10 & 11 from Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies (2023)

&lt;p&gt;ABBV-075 inhibits Bcl-XL transcription and displace BRD4 from Bcl-XL regulatory regions&lt;/p&gt;
Direct Azidation of Phenols (2019)

Direct azidation of phenols was developed. By treating chloroimidazolinium chloride 1b and sodium azide with phenol in the presence of a secondary amine in methoxyethanol, ortho ‐azidation of phenol was achieved.
Progress toward instantaneous microwave photonic spatial-spectral localization (2022)

With emergent fifth-generation (5G) communications systems harnessing ever-higher carrier frequencies and wider instantaneous bandwidths to enable denser user-space and higher data throughput, the ability to address high numbers of users becomes paramount. Existing digital beam-forming technology does not break down gracefully in the presence of a large number of data channels, and high-speed digital-to-analog converters (DACs) are both expensive and power-hungry. The RF-Photonic approach to millimeter-wave (mmW) imaging offers alleviations to this problem by relying on a low-speed phase-locked loop to mitigate phase variations incurred through mechanical means. We present a photonic mmW imager with a fiber arrayed waveguide grating (FAWG), enabling quasi-instantaneous spatial-spectral localization of all incident signals in the array field of regard through optical processing of the up-converted RF field. This configuration additionally enables recovery of the data encoded upon the received carriers through the use of a tunable optical local oscillator, with high-fidelity detection of quadrature amplitude modulation (QAM) signals demonstrated up to a 16-point constellations, and the recovery of multiple signals at once over a wide spectral separation. Additional techniques are presented, using multiple fiber projections to remove the ambiguity between spatial and spectral locations of multiple sources in an RF scene, providing quasi-instantaneous detection of the spatial-spectral location in frequency- and angle-space for each source incident upon the array. In a complete implementation, we expect such a system to possess the capability of simultaneous signal identification and data recovery, contained in a portable form factor for rapid deployment.
Spectroscopy and terahertz imaging for sigillography applications (2011)

Sigillography is the science that studies the manifold aspects of the seals. A seal can be defined as an imprint obtained on a malleable medium by imprinting an incised matrix, which transfers on it the characteristic signs of a person or an institution. We use THz spectroscopy and imaging for non-destructive evaluation of natural materials within old seals. Using a time domain THz spectroscopy and imaging system, THz transmission images are generated in the 0.1–3 THz range and demonstrate that the spectral properties of these materials allow to see across and under a thick layer of old materials.
City scene (2013)

Mobile navigation services are becoming more than merely digital maps; many of them include imagery from the street level. The user can benefit from enriching the 2D-map-based navigation with panoramic imagery from the citizen's perspective, hence gaining an authentic view of the frequent landmarks that urban environments include. In this paper we describe the user-centered design of a mobile street-imagery-based navigation service supporting navigation and exploration of unfamiliar cities. The service was evaluated with a field trial using tourists as participants. The participants used the service freely for the pedestrian navigation tasks that were relevant to them during the trial period. This approach shed light on issues that have not been raised by previous studies on image-based navigation, which have relied on more formal test tasks. The study confirmed that the images help with detecting the destination or assessing the atmosphere of a remote location but brought into focus the real world challenges related to downloading times and positioning accuracy.
Toshiba BRIDJE at NTCIR-5 CLIR: Evaluation using Geometric Means (2005)

Toshiba participated in the Monolingual and Bilingual IR tasks at NTCIR-5 CLIR using the BRIDJE system. We submitted 24 runs covering three topic languages (Japanese, English and Chinese) and two document languages (Japanese and English), and achieved the highest performances in the E-J-T, E-J-D, C-J-T, C-J-D, J-E-T and J-E-D subtasks. This paper (re-)examines Partial Disambiguation and the Pivot Language approach for Bilingual IR, Selective Sampling with memory Resetting for Mono/Bilingual IR and a new Monolingual IR strategy called Bounceand-Throw, using the Geometric Mean versions of Average Precision and Q-measure in addition to the standard Arithmetic Mean ones. Our analyses show that the Geometric Mean, which focusses on the “harder” topics, provides new insight into retrieval effectiveness evaluation.
Analytical comparability to evaluate impact of manufacturing changes of ARX788, an Anti-HER2 ADC in late-stage clinical development (2023)

ARX788 is an anti-HER2 antibody drug conjugate (ADC) developed using Ambrx proprietary Engineered Precision Biologics technology. The manufacturing process of ARX788 has been optimized during the course of early to late-phase clinical development. A comprehensive evaluation of side-by-side comparability between pre- and post-change process for ARX788 drug substance and drug product from a quality perspective was conducted based on ICH Q5E guidelines consisting of batch release assays, physicochemical and biophysical characterization, biological characterization, and forced degradation studies. All results have substantiated a high degree of similarity between the pre- and post-change ARX788 drug substance batches and drug product lots, demonstrating that the process manufacturing changes did not impact product quality.
Optical Bistability of an Injection-Locked Single-Mode Fabry-Perot Laser Diode and Its Application to an Optical Filp-Flop (2007)

We investigate optical bistability of an injection-locked single-mode Fabry-Perot laser diode. Normal and reversed optical bistability curves are observed from the injection-locked laser. And the inverse bistability is used to implement an all-optical flip-flop with the high on-off ratio of over 35 dB.
A Measurement-Based Model for Outdoor Near-Ground Ultrawideband Channels (2015)

Deployment of wireless devices with transceivers in close proximity to the ground has become increasingly attractive for a wide range of applications such as distributed sensor networks and broadband tactical communications. Furthermore, the use of ultrawideband (UWB) signals is attractive for these communications due to their robustness and their suitability for precision ranging and localization. For the development and performance simulation of such systems, accurate channel models are required. The current paper thus presents details of an extensive measurement campaign for near-ground UWB propagation channels and a channel model-based thereon. The measurements were performed with a self-built channel sounder based on arbitrary waveform generation at the transmitter, high-bandwidth sampling oscilloscope at the receiver, and synchronization via electro-optical connections. Various combinations for the antenna height at transmitter and receiver, ranging from 10 cm to 2 m above ground, were measured. We find that the pathloss coefficient (γ) depends significantly on the Tx-Rx antenna heights, while shadowing variance (σ <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) and rms delay-spread (τ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> ) shows smaller dependence. The pathloss shows a slight dependence on frequency; the frequency-dependent pathloss exponent (κ) increases as antennas get closer to the ground. We also found a linear dependency of the rms delay-spread on distance for various antenna height configurations measured. Statistical distributions of all parameters including γ, τ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> , σ <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , and κ are extracted from the measurements. Results are verified by comparing with a second measurement campaign.
Depletion interactions in colloid-polymer mixtures (1996)

We present a neutron-scattering study of depletion interactions in a mixture of a hard-sphere-like colloid and a nonadsorbing polymer. By matching the scattering length density of the solvent with that of the polymer, we measured the partial structure factor ${S}_{c}(Q)$ for the colloidal particles. It is found that the measured ${S}_{c}(Q)$ for different colloid and polymer concentrations can be well described by an effective interaction potential $U(r)$ for the polymer-induced depletion attraction between the colloidal particles. The magnitude of the attraction is found to increase linearly with the polymer concentration, but it levels off at higher polymer concentrations. This reduction in the depletion attraction presumably arises from the polymer-polymer interactions. The experiment demonstrates the effectiveness of using a nonadsorbing polymer to control the magnitude as well as the range of the interaction between the colloidal particles.
Auxora for the Treatment of Patients With Acute Pancreatitis and Accompanying Systemic Inflammatory Response Syndrome (2021)

The favorable safety profile and patient outcomes suggest Auxora may be an appropriate early treatment for patients with AP and SIRS. Clinical development will continue in a randomized, controlled, blinded, dose-ranging study.
New photosensitizers for photodynamic therapy (2016)

Photodynamic therapy (PDT) was discovered more than 100 years ago, and has since become a well-studied therapy for cancer and various non-malignant diseases including infections. PDT uses photosensitizers (PSs, non-toxic dyes) that are activated by absorption of visible light to initially form the excited singlet state, followed by transition to the long-lived excited triplet state. This triplet state can undergo photochemical reactions in the presence of oxygen to form reactive oxygen species (including singlet oxygen) that can destroy cancer cells, pathogenic microbes and unwanted tissue. The dual-specificity of PDT relies on accumulation of the PS in diseased tissue and also on localized light delivery. Tetrapyrrole structures such as porphyrins, chlorins, bacteriochlorins and phthalocyanines with appropriate functionalization have been widely investigated in PDT, and several compounds have received clinical approval. Other molecular structures including the synthetic dyes classes as phenothiazinium, squaraine and BODIPY (boron-dipyrromethene), transition metal complexes, and natural products such as hypericin, riboflavin and curcumin have been investigated. Targeted PDT uses PSs conjugated to antibodies, peptides, proteins and other ligands with specific cellular receptors. Nanotechnology has made a significant contribution to PDT, giving rise to approaches such as nanoparticle delivery, fullerene-based PSs, titania photocatalysis, and the use of upconverting nanoparticles to increase light penetration into tissue. Future directions include photochemical internalization, genetically encoded protein PSs, theranostics, two-photon absorption PDT, and sonodynamic therapy using ultrasound.
47‐3: AMQLED Display with Highly Efficient Oxide N‐P Charge Generation Junction (2019)

We have developed high efficiency tandem quantum‐dot light‐emitting diode (QLED) by using oxide n‐p charge generation junction (CGJ). The tandem QLED with oxide n‐p CGJ exhibits the current efficiency as high as over 120 cd A −1 . The oxide n‐p CGJ shows good Ohmic behavior under forward and reverse bias. It is obvious that the reverse current density is nearly equal to the forward current density, which suggest the efficient charge generation in the oxide n‐p CGJ. In this work, we demonstrated a 4‐inch AMQLED display using high efficiency tandem QLED with oxide n‐p CGJ.
Abstract 5098: GFP compatibility with EdU cell proliferation assay (2014)

Abstract Examining cell proliferation in GFP expressing cells is of general interest in many aspects of biology including regenerative medicine, stem cells, developmental biology and some fields of cancer research. However, visualization of GFP expression is not readily compatible with commonly used proliferation assays which incorporate a thymidine analog to directly measure S-phase proliferation of DNA. With the BrdU (bromo-deoxyuridine) assay, an antibody based detection method, alcohol for fixation and hydrochloric acid for DNA denaturation is commonly used. Neither chemical is compatible with GFP fluorescence. For imaging applications there are some methods to avoid the use of HCl as a denaturant with the BrdU assay, however; they are typically “home-brew” methods used to partially digest the DNA, adding extra steps, and not easily performed. The much faster and reliable EdU (ethynyl-deoxyuridine) cell proliferation assay which uses click chemistry for detection of S-phase proliferation of DNA, uses formaldehyde based fixation and avoids the use of HCl for DNA denaturation. However, the use of copper to catalyse the click reaction also negatively affects GFP fluorescence. Anti-GFP antibodies can be used in the click reaction work flow, to “retrieve” the lost GFP fluorescence but are not convenient and add extra steps. We present recent improvements to the click chemistry based EdU cell proliferation assay which minimizes the loss of GFP and other fluorescent proteins signals and avoids the need for “work around” methods. The resulting click reaction is both more rapid and brighter than the “classic” click EdU assay. The modifications preserve most of the GFP fluorescence and permit multiplex detection with EdU with no change in the work flow of the classic click EdU assay. We optimized components in the improved click reaction conditions and tested compatibility with various fluorescent proteins. Examples of click chemistry and GFP/RFP/mCherry compatibility are presented using the EdU cell proliferation assay in both cell culture and in GFP expressing tissue. Additionally, improvements are demonstrated in with other applications of click chemistry assays used for imaging as well as with on flow cytometry platforms where GFP, R-phycoerythrin (R-PE), or other fluorescent proteins are commonly combined with cell proliferation assays. The use of the modified click reaction is an enabling improvement over originally described copper based click reactions and will further enhance the utility of EdU based cell proliferation. Citation Format: Scott T. Clarke, Zhichao Song, Kelvin Y. Kwan, Carolyn DeMarco, Aleksey Rukavishnikov, Upinder Singh, Kyle Gee. GFP compatibility with EdU cell proliferation assay. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5098. doi:10.1158/1538-7445.AM2014-5098