gebhart/patrepeval huggingface dataset:
Proximity Inference with Wifi-Colocation during the COVID-19 Pandemic (2020)

In this work we propose a WiFi colocation methodology for digital contact tracing. The approach works by having a device scan and store nearby access point information to perform proximity inference. We make our approach resilient to different practical scenarios by configuring a device to turn into a hotspot if access points are unavailable, which makes the approach feasible in both dense urban areas and sparse rural places. We compare various shortcomings and advantages of this work over other conventional ways of doing digital contact tracing. Preliminary results indicate the feasibility of our approach for determining proximity between users, which is relevant for improving existing digital contact tracing and exposure notification implementations.
Shallow junctions-modeling the dominance of point defect charge states during transient diffusion (2003)

Ion implantation damage produces point defects during annealing which can significantly enhance dopant diffusion. This diffusion at low temperatures was studied for P, As, and B implants in Si. Enhanced diffusion was observed below certain doping concentrations which depend only on temperature. For As, this concentration corresponds to As solid stability. For P, enhanced diffusion occurs below n/sub i/ for temperatures below 850 degrees C. A model is presented which correlates the self-interstitial donor level position in the Si bandgap with the dominance of B diffusion via neutral self-interstitials. It is shown that when self-interstitials are externally generated the resulting changes in the free energy of self-interstitial formation force the B diffusion via I/sup x/ (neutral self-interstitial) to be 10-100 times greater than B diffusion via I/sup +/ (donor self-interstitial).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Enantioselective Heterogeneous Synergistic Catalysis for Asymmetric Cascade Transformations (2014)

Abstract A modular design for a novel heterogeneous synergistic catalytic system, which simultaneously activates the electrophile and nucleophile by the combined activation modes of a separate metal and non‐metal catalyst, for asymmetric cascade transformations on a solid surface is disclosed. This modular catalysis strategy generates carbocycles (up to 97.5:2.5 er ) as well as spirocyclic oxindoles (97.5:2.5 to &gt;99:0.5 er ), containing all‐carbon quaternary centers, in a highly enantioselective fashion via a one‐pot dynamic relay process. magnified image
ChemInform Abstract: Synthesis and Bacterial DNA Gyrase Inhibitory Properties of a Spirocyclopropylquinolone Derivative. (1989)

Abstract Coupling of the enol ether (III), prepared by treatment of the β‐keto ester (I) with triethyl orthoformate (II), with the amino alcohol (IV) results in the formation of the cyclopropylaminomethylene compound (V) as a mixture of E‐ and Z‐isomers.
Racking Reflection and Shading Effects on Single Axis Tracked Bifacial Photovoltaic Modules (2022)

Bifacial photovoltaics (PV) is predicted to comprise 80% of the silicon PV share within the next ten years. However, bifacial energy yield models are still undergoing validation, and their uncertainty may slow adoption. One of the challenges of single-axis-tracked (SAT) bifacial PV performance modelling is accurately accounting for the effects of racking elements, such as the frame, module supports, and torque tube, on the rear irradiance. In this work, we calculated front and rear irradiances for the center modules of a 2-in-portrait SAT bifacial photovoltaic system from hourly typical meteorological year data for the Bifacial Test Evaluation Center (BiTEC) site in Livermore, California using bifacial_radiance ray tracing software. For every hourly timestamp, we calculated 2D front and rear irradiance maps in three cases: with no racking, absorptive racking, and reflective racking. From these, we calculated three racking effects: shading, reflection, and shading and reflection combined. We also calculated shading and reflection factors as well as rear irradiance non-uniformity for each case. For the PV system modelled, racking reflection is focused in the same areas of the module as racking shading, partially counteracting shading-induced irradiance reduction and irradiance non-uniformity. For example, for a winter day at noon, racking reflection reduces the rear shading factor from -18.4% to -10.8% and the irradiance non-uniformity from 14.8% to 10.8%. The effects of racking, including both shading and reflection, vary by time of day and year. Accounting for these variations, rather than using annual average correction factors, will improve energy yield prediction accuracy for bifacial PV, especially over short time periods.
Integrative -omics and HLA-ligandomics analysis to identify novel drug targets for ccRCC immunotherapy (2020)

Integration of HLA ligandomics, transcriptomics, genetic, and epigenetic data leads to the identification of novel functionally relevant therapeutic targets for ccRCC immunotherapy. Validation of the identified targets is recommended to expand the treatment landscape of ccRCC.
Data and Spectrum Trading Policies in a Trusted Cognitive Dynamic Network Architecture (2018)

Future wireless networks will progressively displace service provisioning towards the edge to accommodate increasing growth in traffic. This paradigm shift calls for smart policies to efficiently share network resources and ensure service delivery. In this paper, we consider a cognitive dynamic network architecture (CDNA) where primary users (PUs) are rewarded for sharing their connectivities and acting as access points for secondary users (SUs). CDNA creates opportunities for capacity increase by network-wide harvesting of unused data plans and spectrum from different operators. Different policies for data and spectrum trading are presented based on centralized, hybrid, and distributed schemes involving primary operator (PO), secondary operator (SO), and their respective end users. In these schemes, PO and SO progressively delegate trading to their end users and adopt more flexible cooperation agreements to reduce computational time and track available resources dynamically. A novel matching-with-pricing algorithm is presented to enable self-organized SU-PU associations, channel allocation and pricing for data and spectrum with low computational complexity. Since connectivity is provided by the actual users, the success of the underlying collaborative market relies on the trustworthiness of the connections. A behavioral-based access control mechanism is developed to incentivize/penalize honest/dishonest behavior and create a trusted collaborative network. Numerical results show that the computational time of the hybrid scheme is one order of magnitude faster than the benchmark centralized scheme and that the matching algorithm reconfigures the network up to three orders of magnitude faster than in the centralized scheme.
Robust, common path, phase shifting interferometer and optical profilometer (2008)

We describe an improved implementation of our previously reported common-path, phase shifting, and shearing interferometer. Using a time-multiplexed phase shifting scheme, we demonstrate higher sampling resolution, better light sensitivity, and use of arbitrary phase shifting algorithms. We describe microscopic imaging of the surface profile of a copper-plated silicon wafer and demonstrate that the system is vibration insensitive with approximately lambda/100 repeatability. In a more general discussion of our method, we describe the different functional elements and suggest alternative designs and improvements. Possible uses include full-field coherent imaging and high dynamic range wavefront sensing, which we briefly discuss.
Stability and resistance of nickel catalysts for hydrodeoxygenation: carbon deposition and effects of sulfur, potassium, and chlorine in the feed (2014)

The long term stability and resistance toward carbon deposition, sulfur, chlorine, and potassium of Ni/ZrO2 as a catalyst for the hydrodeoxygenation (HDO) of guaiacol in 1-octanol (as a model compound system for bio-oil) has been investigated at 250 °C and 100 bar in a trickle bed reactor setup. Without impurities in the feed good stability of the Ni/ZrO2 catalyst could be achieved over more than 100 h of operation, particularly for a sample prepared with small Ni particles, which minimized carbon deposition. Exposing the catalyst to 0.05 wt% sulfur in the feed resulted in rapid deactivation with complete loss of activity due to the formation of nickel sulfide. Exposing Ni/ZrO2 to chlorine-containing compounds (at a concentration of 0.05 wt% Cl) on-stream led to a steady decrease in activity over 40 h of exposure. Removal of the chlorine species from the feed led to the regaining of activity. Analysis of the spent catalyst revealed that the adsorption of chlorine on the catalyst was completely reversible, but chlorine had caused sintering of nickel particles. In two experiments, potassium, as either KCl or KNO3, was impregnated on the catalyst prior to testing. In both cases deactivation was persistent over more than 20 h of testing and severely decreased the deoxygenation activity while the hydrogenation of guaiacol was unaffected. Overall, sulfur was found to be the worst poison, followed by potassium and then chlorine. Thus, removal/limitation of these species from bio-oil is a requirement before long term operation can be achieved with this catalyst.
The LD78β Isoform of MIP-1α Is the Most Potent CC-Chemokine in Inhibiting CCR5-Dependent Human Immunodeficiency Virus Type 1 Replication in Human Macrophages (2001)

The CC-chemokines RANTES, macrophage inflammatory protein 1alpha (MIP-1alpha), and MIP-1beta are natural ligands for the CC-chemokine receptor CCR5. MIP-1alpha, also known as LD78alpha, has an isoform, LD78beta, which was identified as the product of a nonallelic gene. The two isoforms differ in only 3 amino acids. LD78beta was recently reported to be a much more potent CCR5 agonist than LD78alpha and RANTES in inducing intracellular Ca2+ signaling and chemotaxis. CCR5 is expressed by human monocytes/macrophages (M/M) and represents an important coreceptor for macrophage-tropic, CCR5-using (R5) human immunodeficiency virus type 1 (HIV-1) strains to infect the cells. We compared the antiviral activities of LD78beta and the other CC-chemokines in M/M. LD78beta at 100 ng/ml almost completely blocked HIV-1 replication, while at the same concentration LD78alpha had only weak antiviral activity. Moreover, when HIV-1 infection in M/M was monitored by a flow cytometric analysis using p24 antigen intracellular staining, LD78beta proved to be the most antivirally active of the chemokines. RANTES, once described as the most potent chemokine in inhibiting R5 HIV-1 infection, was found to be considerably less active than LD78beta. LD78beta strongly downregulated CCR5 expression in M/M, thereby explaining its potent antiviral activity.
A novel self-sintering microparticle-based system for regenerative medicine (2008)

The use of injectable scaffolds has raised great interest as they minimise the need for invasive surgery and its associated complications, costs and discomfort to the patient. Furthermore, they can fill cavities of any size or shape as well as being able to deliver a localised therapeutic agent. The aim of this study was to develop an injectable scaffold using PLGA microparticles which may be able to (i) carry cells and/or drugs to a site of injury (ii) be delivered via a narrow bore needle, and (iii) form a scaffold in situ with sufficient mechanical properties. The investigated system exploits a novel in situ solidification mechanism (liquid sintering) whereby the injectable microparticle-based precursors solidify into 3D constructs in response to thermal changes [2]. Thus, we demonstrate that PLGA microparticles incorporated with Triton X-100 are thermally responsive at body temperature (37°C) and may be exploited in regenerative medical applications.
Engineered Zinc-Finger Proteins Can Compensate Genetic Haploinsufficiency by Transcriptional Activation of the Wild-Type Allele: Application to Willams-Beuren Syndrome and Supravalvular Aortic Stenosis (2012)

Williams-Beuren syndrome (WBS) and supravalvular aortic stenosis (SVAS) are genetic syndromes marked by the propensity to develop severe vascular stenoses. Vascular lesions in both syndromes are caused by haploinsufficiency of the elastin gene. We used these distinct genetic syndromes as models to evaluate the feasibility of using engineered zinc-finger protein transcription factors (ZFPs) to achieve compensatory expression of haploinsufficient genes by inducing augmented expression from the remaining wild-type allele. For complex genes with multiple splice variants, this approach could have distinct advantages over cDNA-based gene replacement strategies. Targeting the elastin gene, we show that transcriptional activation by engineered ZFPs can induce compensatory expression from the wild-type allele in the setting of classic WBS and SVAS genetic mutations, increase elastin expression in wild-type cells, induce expression of the major elastin splice variants, and recapitulate their natural stoichiometry. Further, we establish that transcriptional activation of the mutant allele in SVAS does not overcome nonsense-mediated decay, and thus ZFP-mediated transcriptional activation is not likely to induce production of a mutant protein, a crucial consideration. Finally, we show in bioengineered blood vessels that ZFP-mediated induction of elastin expression is capable of stimulating functional elastogenesis. Haploinsufficiency is a common mechanism of genetic disease. These findings have significant implications for WBS and SVAS, and establish that haploinsufficiency can be overcome by targeted transcriptional activation without inducing protein expression from the mutant allele.
ChemInform Abstract: Stereoselective Synthesis of β‐Ketoesters from Prop‐2‐yn‐1‐ols. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Proposal of Security Requirements Definition Methodology in Connected Car Systems by CVSS V3 (2016)

The use of connected cars has been spreading recently. Security for connected cars is very important because an attacker can access connected cars remotely. Security requirements defined based on risk assessment are necessary to protect connected cars from attackers. However, the conventional risk assessment technique mostly depends on the evaluator's security knowledge. Therefore, we propose a security requirement definition methodology for connected car systems. The proposed methodology is based on the security requirements definition methodology in IoT (Internet of Things) systems, which consists of four processes: modelization of target system, definition of security problems, consideration of security requirements, and decision of security function components. We applied the methodology in IoT systems to connected car systems. In particular, the risk assessment, which is executed to define security problems, uses CVSS v3 which was released in 2015. We can assess the risk of connected car systems objectively by using the base metrics of CVSS v3.
ChemInform Abstract: Intramolecular Diels‐Alder Reactions of 1,2,4‐Triazines. Synthesis of 2,3‐Cyclopentenopyridines and 5,6,7,8‐Tetrahydroquinolines. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Integrable InGaAs/GaAs vertical-cavity surface-emitting lasers (1993)

A new electrically isolated bottom-emission vertical-cavity surface-emitting laser structure with a novel contacting method is demonstrated. The structure is grown on semi-insulating material and contacts are made to an n-type intracavity contact layer and the top of a low-resistance Al0.67Ga0.33As/ GaAs p-type distributed Bragg reflector. This structure offers the advantages of device isolation and low parasitic capacitance without sacrificing performance. Small devices (10μm or less in diameter) perform as well as the best lasers reported in the literature.
The polyphase cascaded-cell DC/DC converter (2013)

This paper describes a new type of unisolated dc/dc converter employing cascaded converter cells, and its operation is analyzed. The topology and the operation of the converter have similarities with the modular multilevel converter for polyphase ac/dc conversion, but the ac voltages and currents are in this case only employed for redistributing power within the converter. It is shown how the nominal modulation indices for ac and dc voltage influence the semiconductor expenditure for the converter. A methodology for optimizing the design of the converter with regard to the required silicon area is devised. It is found that at voltage conversion ratios close to unity it is preferable to use a combination of full-bridge cells and half-bridge cells. Under such circumstances the proposed converter can offer lower semiconductor expenditure than a conventional buck converter.
Cytokine-induced F-actin reorganization in endothelial cells involves RhoA activation (2009)

Acute ischemic kidney injury results in marked increases in local and systemic cytokine levels. IL-1alpha, IL-6, and TNF-alpha orchestrate various inflammatory reactions influencing endothelial permeability by altering cell-to-cell and cell-to-extracellular matrix attachments. To explore the role of actin and the regulatory proteins RhoA and cofilin in this process, microvascular endothelial cells (MS1) were exposed to individual cytokines or a cytokine cocktail. Within minutes, a marked, time-dependent redistribution of the actin cytoskeleton occurred with the formation of long, dense F-actin basal stress fibers. The concentration of F-actin, normalized to nuclear staining, significantly increased compared with untreated cells (up 20%, P < or = 0.05). Western blot analysis of MS1 lysates incubated with the cytokine cocktail for 4 h showed an increase in phosphorylated/inactive cofilin (up 25 +/- 15%, P < or = 0.05) and RhoA activation (up to 227 +/- 26% increase, P < or = 0.05) compared with untreated cells. Decreasing RhoA levels using small interfering RNA blocked the effect of cytokines on stress fiber organization. Treatment with Y-27632, an inhibitor of the RhoA effector p160-ROCK, decreased levels of phosphorylated cofilin and reduced stress fiber fluorescence by 22%. In cells treated with Y-27632 followed by treatment with the cytokine cocktail, stress fiber levels were similar to control cells and cofilin phosphorylation was 55% of control levels. Taken together, these studies demonstrate cytokine stimulation of RhoA, which in turn leads to cofilin phosphorylation and formation of numerous basal actin stress fibers. These results suggest cytokines signal through the Rho-ROCK pathway, but also through another pathway to affect actin dynamics.
Data and Reporting Quality in Tympanoplasty and Ossiculoplasty Studies (2017)

Objective The objective of our study was to check the documentation of hearing outcome parameters and influencing factors (surgical, pathological, and methodological) in published literature evaluating hearing outcome after tympanoplasty. We aimed to assess how effectively the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) 1995 guidelines were applied. Study Design Retrospective noncontrolled study. Setting Ear research center. Subjects and Methods This study was based on a PubMed research, including peer-reviewed English-speaking original studies published from January 2005 to December 2015. In total, 169 studies were checked for correct description of study population, surgical methodology, study design, and documentation of the hearing outcome. In addition, the correct application of AAO-HNS 1995 criteria was checked. Results Pre- and postoperative air-bone gap were shown as mean ± standard deviation in half of all series (52% vs 56%). The recommended frequency spectrum (0.5-3 kHz) was used in 46%, while a documentation of frequency spectrum was available in 85%. Whereas a statement on presence of stapes suprastructure (81%) and initial pathology was usually available, mucosa status (17%) and aeration (8%) were only shown in few series. Revision cases, staged cases, and myringoplasty graft material were documented in 46% to 57%. Type and material of prosthesis were represented in 74% to 82%. None of the publications analyzed fulfilled all 10 AAO-HNS criteria. In 10%, 7 to 9 criteria were used correctly. Conclusion A heterogeneous description of surgical and pathological findings and the application of minimal reporting standards are essential preconditions to enable comparisons between different studies and to generate meta-analysis.
Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo (2014)

Many active components derived from edible natural resources such as plant extracts have recently attracted attention for their potential use as functional foods or drugs for preventing and treating metabolic diseases such as diabetes. To obtain a novel modulator of glucose metabolism, we conducted screening of a small compound library in cultured L6 myotubes. We identified nepodin that stimulated glucose uptake dose-dependently in differentiated L6 myotubes. The stimulatory effect of nepodin on glucose uptake was abrogated by a 5'-adenosine monophosphate-activated protein kinase (AMPK) inhibitor. In addition, nepodin stimulated the phosphorylation of AMPK. Nepodin also stimulated the translocation of GLUT4 to the plasma membrane in L6 myoblasts transfected with a Glut4 cDNA-coding vector and in differentiated L6 myotubes. In in vivo study, nepodin suppressed the increases in fasting blood glucose levels and improved the glucose intolerance of C57BL/KsJ-db/db mice, a type 2 diabetic animal model. Nepodin rescued the impaired phosphorylation of AMPK in the skeletal muscle of db/db mice. These results suggest that nepodin has an antidiabetic effect, which is at least partly mediated by stimulation of GLUT4 translocation via AMPK activation by nepodin.
Primate Lentivirus Capsid Sensitivity to TRIM5 Proteins (2008)

Mammalian cells express several factors that inhibit lentiviral infection and that have been under strong selective pressure. One of these factors, TRIM5, targets the capsid protein of incoming retrovirus particles and inhibits subsequent steps of the replication cycle. By substituting human immunodeficiency virus type 1 capsid, we were able to show that a set of divergent primate lentivirus capsids was generally not susceptible to restriction by TRIM5 proteins from higher primates. TRIM5alpha proteins from other primates exhibited distinct restriction specificities for primate lentivirus capsids. Finally, we identified novel primate lentiviral capsids that are targeted by TRIMCyp proteins.