gebhart/patrepeval huggingface dataset:
<title>Nonlinear signal model for magnetic-tape recording channels utilizing magneto-resistive heads</title> (1996)

As bit and track densities increase, more complex detection schemes must be devised to combat the nonlinearities inherent in high-density magnetic-recording channels. With an accurate model we can quantify the departure of the channel from linear superposition, leading to optimized detectors providing improved system performance. Two distinct models have been developed. The first attempts to account for many nonlinear effects created by the physical properties of the medium; the other tries to combine all of these effects into a simple nonlinear function. Both models show excellent agreement using parameters derived from experimental signals. Simpler detection schemes result from the second model, while the first, more complex, model ensures preservation of generality. Apart from devising nonlinear detectors, we can also generate pseudo-random signals with enhanced nonlinear distortions, which may be used to test the robustness of various detection schemes. In this paper we present the results of parameter extraction and nonlinear distortion for several magneto- resistive tape-recording channels at a wide range of densities.
management (SAM): a novel framework for cancer survivorship (2010)

Background: We propose a novel framework for management of cancer survivorship: electronic patient SelfAssessment and Management (SAM). SAM is a framework for transfer of information to and from patients in such a way as to increase both the patient's and the health care provider's understanding of the patient's progress, and to help ensure that patient care follows best practice. Methods: Patients who participate in the SAM system are contacted by email at regular intervals and asked to complete validated questionnaires online. Patient responses on these questionnaires are then analyzed in order to provide patients with real-time, online information about their progress and to provide them with tailored and standardized medical advice. Patient-level data from the questionnaires are ported in real time to the patient's health care provider to be uploaded to clinic notes. An initial version of SAM has been developed at Memorial Sloan-Kettering Cancer Center (MSKCC) and the University of California, San Francisco (UCSF) for aiding the clinical management of patients after surgery for prostate cancer. Results: Pilot testing at MSKCC and UCSF suggests that implementation of SAM systems are feasible, with no major problems with compliance (> 70% response rate) or security. Conclusion: SAM is a conceptually simple framework for passing information to and from patients in such a way as to increase both the patient's and the health care provider's understanding of the patient's progress, and to help ensure that patient care follows best practice.
Fast animation of turbulence using energy transport and procedural synthesis (2008)

We present a novel technique for the animation of turbulent fluids by coupling a procedural turbulence model with a numerical fluid solver to introduce subgrid-scale flow detail. From the large-scale flow simulated by the solver, we model the production and behavior of turbulent energy using a physically motivated energy model. This energy distribution is used to synthesize an incompressible turbulent velocity field, whose features show plausible temporal behavior through a novel Lagrangian approach for advected noise. The synthesized turbulent flow has a dynamical effect on the large-scale flow, and produces visually plausible detailed features on both gaseous and free-surface liquid flows. Our method is an order of magnitude faster than full numerical simulation of equivalent resolution, and requires no manual direction.
Tagged Mutagenesis by Efficient Minos-Based Germ Line Transposition (2009)

Germ line gene transposition technology has been used to generate "libraries" of flies and worms carrying genomewide mutations. Phenotypic screening and DNA sequencing of such libraries provide functional information resulting from insertional events in target genes. There is also a great need to have a fast and efficient way to generate mouse mutants in vivo to model developmental defects and human diseases. Here we describe an optimized mammalian germ line transposition system active during early mouse spermatogenesis using the Minos transposon. Transposon-positive progeny carry on average more than 2 new transpositions, and 45 to 100% of the progeny carry an insertion in a gene. The optimized Minos-based system was tested in a small rapid dominant functional screen to identify mutated genes likely to cause measurable cardiovascular "disease" phenotypes in progeny/embryos. Importantly this system allows rapid screening for modifier genes.
Biolithography: DNA-assisted Manufacturing of Nanodevices for Optical and Electronic Biosensing (2007)

A novel top-down and bottom-up approaches enables us to interact with complex biological systems: tissues, cells, proteins and DNA in an unprecedented manner. In addition, new tools, such as arrays of nanoparticles and nanowires can be created on a large scale with promising applications in electronic and optical biosensing.
Transactional memory (2012)

column Share on Transactional memory: beyond the first two decades Authors: Maurice Herlihy Brown University MIT Brown University MITView Profile , Nir Shavit Tel-Aviv University Tel-Aviv UniversityView Profile Authors Info & Claims ACM SIGACT NewsVolume 43Issue 4December 2012 pp 101–103https://doi.org/10.1145/2421119.2421138Online:19 December 2012Publication History 2citation344DownloadsMetricsTotal Citations2Total Downloads344Last 12 Months1Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
ChemInform Abstract: Stereoselective Hydrogen Transfer Reactions Involving Acyclic Radicals. Tandem Substituted Tetrahydrofuran Formation and Stereoselective Reduction: Synthesis of the C17‐C22 Subunit of Ionomycin. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Darstellung von (R)-2-(Sulfonyloxy)nitrilen und ihre Reaktionen mit Acetaten : Konfigurationsumkehr optisch aktiver Cyanhydrine (Enzym-katalysierte Reaktionen ; 15) (1993)

2-(Sulfonyloxy)nitriles (R)-6, 7, 8 are obtained in high optical purity from the respective cyanohydrins (R)-2 by sulfonylation with methanesulfonyl chloride (3), toluenesulfonyl chloride (4), and trifluoromethanesulfonic anhydride (5), respectively. In contrast to the aliphatic (sulfonyloxy)nitriles (R)-6, 7, 8a - e, the benzylic-type mandelic acid derivatives (R)-7,8í are unstable at higher temperature. The 2-(sulfonyloxy)nitriles (R)1- 6, 7, 8a - e react at room temperature with alkali acetates in a typical SN2 manner to give the cyanohydrin acetates (S)-9 in high optical purity. Under these reaction conditions, however, the mandelic-type compounds (R)-7, 8í partly racemize and decompose. By hydrolysis of the acetates (S)-9, (S)1-cyanohydrins (S)-2 of aliphatic aldehydes are easily available.
A Perspective on Differential Microphone Arrays in the Context of Noise Reduction (2011)

In this correspondence, we study the performance of differential microphone arrays (DMAs) in terms of noise reduction, speech distortion, and signal-to-noise ratio (SNR) gain. We also investigate their beampatterns and array gains. We start by establishing the expressions of these performance measures involving general derivatives of the channel transfer functions. Afterwards, we specify our results in the case of anechoic near-field and far-field propagation models.
Orienteering with One Endomorphism (2023)

In supersingular isogeny-based cryptography, the path-finding problem reduces to the endomorphism ring problem. Can path-finding be reduced to knowing just one endomorphism? It is known that a small degree endomorphism enables polynomial-time path-finding and endomorphism ring computation (in: Love and Boneh, ANTS XIV-Proceedings of the Fourteenth Algorithmic Number Theory Symposium, volume 4 of Open Book Ser. Math. Sci. Publ., Berkeley, 2020). An endomorphism gives an explicit orientation of a supersingular elliptic curve. In this paper, we use the volcano structure of the oriented supersingular isogeny graph to take ascending/descending/horizontal steps on the graph and deduce path-finding algorithms to an initial curve. Each altitude of the volcano corresponds to a unique quadratic order, called the primitive order. We introduce a new hard problem of computing the primitive order given an arbitrary endomorphism on the curve, and we also provide a sub-exponential quantum algorithm for solving it. In concurrent work (in: Wesolowski, Advances in cryptology-EUROCRYPT 2022, volume 13277 of Lecture Notes in Computer Science. Springer, Cham, 2022), it was shown that the endomorphism ring problem in the presence of one endomorphism with known primitive order reduces to a vectorization problem, implying path-finding algorithms. Our path-finding algorithms are more general in the sense that we don't assume the knowledge of the primitive order associated with the endomorphism.
New Series of Mixed Pronucleotides. Synthesis and Anti-HIV Activities of Mononucleoside Phenyl SATE Phosphotriesters (1999)

The synthesis and anti-HIV activities of phenyl S-pivaloyl-2-thioethyl (tBuSATE) phosphotriesters of AZT and d4T are reported. These compounds show similar activity compared to bis(tBuSATE) phosphotriesters and appear to be able to deliver the corresponding 5'-mononucleotides inside the cells.
LOW FREQUENCY NOISE IN GALLIUM NITRIDE FIELD EFFECT TRANSISTORS (2002)

We report on experimental study of the low frequency noise in GaN-based Field Effect Transistors. In both GaN Metal Semiconductor Field Effect Transistors (MESFETs) and AlGaN/GaN Heterostructure Field Effect Transistors (HFETs), the main noise sources are located in the channel. Gate voltage dependence of noise in MESFETs complies with the Hooge formula and indicates the bulk origin of noise. The dependencies of the Hooge parameter, α, on sheet electron concentration n s in HFETs are extracted from measured drain current fluctuations taking into account the contact resistance, and the resistance of the ungated regions of the transistors. At low channel concentrations α is inversely proportional to n s (α ~ 1/n s ). This dependence as well as the temperature dependence of noise might be explained by electron tunneling from the 2D gas into the traps in the bulk GaN or AlGaN.
Oral Nonviral Gene Delivery for Chronic Protein Replacement Therapy (2018)

Efficient nonviral oral gene delivery offers an attractive modality for chronic protein replacement therapy. Herein, the oral delivery of insulin gene is reported by a nonviral vector comprising a copolymer with a high degree of substitution of branched polyethylenimine on chitosan (CS-g-bPEI). Protecting the plasmid from gastric acidic degradation and facilitating transport across the gut epithelium, the CS-g-bPEI/insulin plasmid DNA nanoparticles (NPs) can achieve systemic transgene expression for days. A single dose of orally administered NPs (600 µg plasmid insulin (pINS)) to diabetic mice can protect the animals from hyperglycemia for more than 10 d. Three repeated administrations spaced over a 10 d interval produce similar glucose-lowering results with no hepatotoxicity detected. Positron-emission-tomography and computed-tomography images also confirm the glucose utilization by muscle cells. While this work suggests the feasibility of basal therapy for diabetes mellitus, its significance lies in the demonstration of a nonviral oral gene delivery system that can impact chronic protein replacement therapy and DNA vaccination.
Internet-Marks: the secure seal for WWW site authentication (2002)

The paper describes a seal that is secure enough for both the seal and Web page contents to be protected against forgery. It also enables the copying of Web contents to an unauthorized site to be detected. The paper explains the Internet Marks and compares their security and speed with those of conventional seal methods.
ChemInform Abstract: Synthesis of Proteins by Subtiligase (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M1‐acetylcholine receptor agonist: A randomized cross‐over trial (2021)

HTL0009936 showed well-characterized pharmacokinetics and single doses were safe and generally well-tolerated in healthy elderly subjects. Due to physostigmine tolerability issues and subject burden, the study design was changed and some pharmacodynamic assessments (neurocognitive) were performed at suboptimal drug exposures. Therefore no clear conclusions can be made on pharmacodynamic effects of HTL0009936, although an effect on P300 is suggestive of central target engagement.
Expression and Endocytosis of Lysosomal Aspartylglucosaminidase in Mouse Primary Neurons (1998)

Aspartylglucosaminuria (AGU) is a neurodegenerative lysosomal storage disease that is caused by mutations in the gene encoding for a soluble hydrolase, aspartylglucosaminidase (AGA). In this study, we have used our recently developed mouse model for AGU and analyzed processing, intracellular localization, and endocytosis of recombinant AGA in telencephalic AGU mouse neurons in vitro. The processing steps of AGA were found to be similar to the peripheral cells, but both the accumulation of the inactive precursor molecule and delayed lysosomal processing of the enzyme were detected. AGA was distributed to the cell soma and neuronal processes but was not found in the nerve terminals. Endocytotic capability of cultured telencephalic neurons was comparable to that of fibroblasts, and endocytosis of AGA was blocked by free mannose-6-phosphate (M6P), indicating that uptake of the enzyme was mediated by M6P receptors (M6PRs). Uptake of extracellular AGA was also studied in the tumor-derived cell lines rat pheochromocytoma (PC12) and mouse neuroblastoma cells (N18), which both endocytosed AGA poorly as compared with cultured primary neurons. Expression of cation-independent M6PRs (CI-M6PRs) in different cell lines correlated well with the endocytotic capability of these cells. Although a punctate expression pattern of CI-M6PRs was found in fibroblasts and cultured primary neurons, the expression was beyond the detection limit in PC12 and N18 cells. This indicates that PC12 and N18 are not feasible cell lines to describe neuronal uptake of mannose-6-phosphate-tagged proteins. This in vitro data will form an important basis for the brain-targeted therapy of AGU.
Synthesis of Aryl Sulfonamides via Palladium-Catalyzed Chlorosulfonylation of Arylboronic Acids (2013)

A palladium-catalyzed method for the preparation of sulfonamides is described. The process exhibits significant functional group tolerance and allows for the preparation of a number of arylsulfonyl chlorides and sulfonamides under mild conditions.
Measuring Cross-Track Thermal Gradient in Heat-Assisted Magnetic Recording (2019)

The areal density achievable with heat-assisted magnetic recording (HAMR) is directly related to the temperature gradient produced in the recording media by the near-field transducer. The thermal gradient in the down track direction affects the linear density, while the thermal gradient in the cross-track direction determines the achievable track density. While characterizing the cross-track thermal gradient (CTTG) is critical to understanding recording performance in HAMR, to date few details on how to accurately measure this quantity have appeared in the literature. Here, we describe a method to determine the CTTG in HAMR that avoids common distortions such as the cross-track variation in reader sensitivity. It also allows the thermal gradient produced on each side of the head to be measured separately and can measure the pure thermal gradient (without the effect of the magnetic field produced by the pole) or the effective gradient produced by the combination of the thermal gradient and the magnetic field.
Modeling and simulation of the ultrasound signal backscattered by blood (2003)

A new model is proposed to simulate the power backscattered by blood. The model is that of a space-invariant linear system which takes into consideration the blood stochastic scattering properties as well as the characteristics of the ultrasound system. The model allowed the study of the backscattered power as a function of the hematocrit for nonaggregating red blood cells (RBCs), and the level of RBC aggregation determined by the flow shear rate. RBC aggregation was simulated in a Couette flow at 40% hematocrit and shear rates of 0.01 s/sup -1/ to 10 s/sup -1/. For nonaggregating RBCs, the power as a function of the hematocrit matched theoretical predictions and experimental results. The maximum aggregation and backscattered power were obtained around 0.6 s/sup -1/.
ChemInform Abstract: Synthesis of Oligo‐enynes Using [Fe(alkene)(CO)n] Scaffolds. Z/E‐Selective Wittig‐ and Horner‐Type Olefination Reactions of β‐Carbonyl Groups in η4‐Diene and γ‐Carbonyl Groups in η2‐Alkene Complexes of Iron. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Scheduling of Soft Real-time Systems for Context-aware Applications (2008)

Context-aware applications pose new challenges, including a need for new computational models, uncertainty management, and efficient optimization under uncertainty. Uncertainty can arise at two levels: multiple and single tasks. When a mobile user changes environments, the context changes resulting in the possibility of the user requesting tasks which are specific for the new environment. However, as the user moves these requested tasks may no longer be context relevant. Additionally, the runtime of each task is often highly dependent on the input data. We introduce a hierarchical multi-resolution statistical task model that captures relevant aspects at the task and intertask levels, and captures not only uncertainty, but also introduces the notion of utility for the user. We have developed a system of non-parametric statistical techniques for modeling the runtime of a specific task. This model is a framework where we define problems of design and optimization of statistical soft real-time systems (SSRTS). The main algorithmic novelty is a cumulative potential-based task scheduling heuristic for maximizing utility. The heuristic conducts global optimization and induces low runtime overhead. We demonstrate the effectiveness of the scheduling heuristic using a Trimaran-based evaluation platform. 1.
Hanle spin precession in a two-terminal lateral spin valve (2019)

Spin voltages due to Hanle spin precession in a two-terminal (2T) device, composed of a silicon channel and two ferromagnetic tunnel contacts (Fe/MgO), are observed and explained. The 2T Hanle signals contain not only contributions due to spin transport from one electrode to the other but also local contributions from the spin accumulation in the Si created and detected at each of the two contacts separately. Consequently, the salient features of the 2T Hanle signals differ from those in nonlocal devices and the familiar correspondence between Hanle and spin-valve signals is absent. The local and transport contributions to the 2T Hanle signal can be disentangled and described by the same set of device parameters as the nonlocal Hanle signals.
Induction of primary antiphospholipid syndrome in mice by immunization with a human monoclonal anticardiolipin antibody (H-3). (1992)

Antiphospholipid syndrome (APLS) is characterized by thrombocytopenia, thromboembolic phenomena, and recurrent fetal loss, associated with anticardiolipin antibodies (ACA) and/or lupus anticoagulant. The syndrome may be primary or may be associated with other conditions such as systemic lupus erythematosus. We have previously shown the ability to induce APLS in naive mice following passive transfer of serum and monoclonal ACAs. Similarly we generated the secondary APLS in BALB/c mice following immunization with a pathogenic anti-DNA antibody. In the current study we report on the induction of primary APLS following immunization of BALB/c mice with a human monoclonal ACA (H-3). The mice developed high persistent titers of ACA. The APLS was characterized by prolonged activated partial thromboplastin time, low fecundity rate (21% vs. 48% of control immunized mice), high resorption index of fetuses (25% vs. 3%), and low weights of embryos and placentae. Our study points to the ability of inducing primary APLS in naive mice. The induction of various presentations of APLS by different ACA may explain the diversity of clinical manifestations seen in patients with APLS.
Prostatic intraepithelial neoplasia and adenocarcinoma in mice expressing a probasin- Neu oncogenic transgene (2006)

NEU (ERBB2) and other members of the epidermal growth factor receptor (EGFR) family have been implicated in human prostate cancer (CAP) development and progression to an androgen-independent state, but the extent of involvement and precise role of this signaling pathway remain unclear. To begin addressing such open questions in an animal model, we have developed a transgenic line in which an oncogenic Neu cDNA (Neu*) driven by the probasin gene promoter is overexpressed in the mouse prostate and causes development of prostatic intraepithelial neoplasia (PIN) that progresses to invasive carcinoma. Expression profiling using microarrays, which was selectively validated and extended by immunophenotyping of Neu*-induced PIN and CAP, led to the identification of some novel biomarkers and also revealed increased expression of Egfr, Erbb3 and phosphorylated androgen receptor. In view of this information from our mouse model, which can be used to analyze further the role of Erbb signaling in prostatic tumorigenesis, we examined human prostate cancer tissue arrays by immunohistochemistry. Based on statistical analyses of the results, we propose the testable hypothesis that ERBB3, shown to be expressed in 86% of the human CAP cases that we examined, is the pivotal element of the Erbb pathway promoting tumorigenesis by heterodimerization with NEU or EGFR, while a NEU/EGFR dimer does not appear to play a significant role in CAP.