gebhart/patrepeval huggingface dataset:
Toward Secure IoT Networks in Healthcare Applications: A Game-Theoretic Anti-Jamming Framework (2022)

The Internet of Things (IoT) is used to interconnect a massive number of heterogeneous resource-constrained smart devices. This makes such networks exposed to various types of malicious attacks. In particular, jamming attacks are among the most common harmful attacks to IoT networks. Therefore, an anti-jamming power allocation (PA) strategy is first proposed in this article for health monitoring IoT networks by exploiting the game theory to minimize the worst case jamming effect under multichannel fading. This strategy uses an iterative algorithm based on gradient descent to identify the Nash Equilibrium (NE) of the game. An artificial neural network (ANN) model is also proposed to accelerate the convergence of the algorithm making it more suitable for IoT networks. Furthermore, novel data population (DP), extension, and balancing techniques are proposed to enhance the efficiency of the proposed strategy in combating jamming attacks even for network configurations that were never used in the training phase. In addition, time and spatial diversities are exploited using a heterogeneous iterative algorithm to enhance the security of the network.
A Framework for Future Radio Access (2005)

A framework for future radio-access systems, enabling user data rates up to 100 Mbps with wide-area coverage and up to 1 Gbps for local-area coverage, is presented. The proposed framework supports flexibility in system bandwidth and duplex arrangements. Furthermore, support for relaying and advanced antenna solutions is integrated in the design of the framework. We believe that the proposed framework provides a suitable platform for development and evaluation of novel techniques required for future radio-access solutions.
Identification of Active Metal Carbide and Nitride Catalytic Facets for Hydrodeoxygenation Reactions (2021)

The catalytic hydrodeoxygenation (HDO) reaction is of considerable interest for biomass conversion to valuable chemicals and fuels, where one of the critical bottlenecks is the lack of cost-effective and efficient catalysts. To discover cost-efficient catalysts for the HDO reaction, we employed a density functional theory-based hierarchical catalyst design strategy based on catalytic descriptors, reaction energy profiles, and microkinetic modeling (MKM). We focused on the carbide and nitride catalyst space, for which we calculated 121 catalyst surfaces of Mo2C, MoC, Mo2N, W2C, NbC, VC, VN, and NbN catalysts. Based on the computed surface energies, reaction energies of oxygen removal, carbon binding strength, and the surface area of nanoparticles, the likely active facets are the Mo2C(111), MoC(011), VN(100), Mo2N(001), Mo2N(011), and Mo2N(100) surfaces. Further, detailed energy profiles were obtained, and MKM was performed for a model reaction (glycolaldehyde + 2H2 → ethylene + 2H2O) on the Mo2C(111), VN(100), and MoC(100) surfaces. Based on the computed volcano map obtained from MKM, the predicted active facets for this HDO reaction are the Mo2C(111), MoC(011), VN(011), Mo2N(001), Mo2N(011), and Mo2N(100) surfaces. Additionally, none of the carbide and nitride catalyst surfaces are located in the optimal catalytic activity part. Therefore, it is essential to modify the catalyst via adding dopants or alloying to improve the catalytic activity. Catalytic modifications that can destabilize the surface adsorption of O*/H2O* and decrease the energy barriers of O–H bond formation are recommended to facilitate the HDO on the carbide and nitride catalysts. These a priori investigations provide guidelines for future low-cost HDO catalyst development.
Data from Androgen Receptor Upregulation Mediates Radioresistance after Ionizing Radiation (2023)

&lt;div&gt;Abstract&lt;p&gt;Clinical trials have established the benefit of androgen deprivation therapy (ADT) combined with radiotherapy in prostate cancer. ADT sensitizes prostate cancer to radiotherapy-induced death at least in part through inhibition of DNA repair machinery, but for unknown reasons, adjuvant ADT provides further survival benefits. Here, we show that androgen receptor (AR) expression and activity are durably upregulated following radiotherapy in multiple human prostate cancer models &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;. Moreover, the degree of AR upregulation correlates with survival &lt;i&gt;in vitro&lt;/i&gt; and time to tumor progression in animal models. We also provide evidence of AR pathway upregulation, measured by a rise in serum levels of AR-regulated hK2 protein, in nearly 20% of patients after radiotherapy. Furthermore, these men were three-fold more likely to experience subsequent biochemical failure. Collectively, these data demonstrate that radiotherapy can upregulate AR signaling after therapy to an extent that negatively affects disease progression and/or survival. &lt;i&gt;Cancer Res; 75(22); 4688–96. ©2015 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Conformational Preferences for Solvated Hydroxymethyl Groups in Hexopyranose Structures (1973)

The effect of the 4-hydroxyl group on the conformational preferences of the hydroxymethyl group in water, dimethyl sulfoxide, 1,2-dichloroethane, and mixtures of the latter two solvents was assessed by comparing 1,2-anhydro-2,3,4-trideoxy-D-glycero-hexitol with 1,5-anhydro-2,3-dideoxy-D-erythro-hexitol and its mono- and dimethyl ethers and with 1,5-anhydro-2,3-dideoxy-D-threo-hexitol. NMR, empirical rules for optical rotation at the D-line of sodium and when possible infrared absorption were used. The effect of the ring-oxygen atom was compared with that of a methylene group by examining the diastereoisomeric 2-hydroxymethylcyclohexanols. Conclusions are drawn regarding solvation effects on non-bonded interactions and on intramolecular hydrogen bonding.
Adjuvant therapy in patients with sarcomatoid renal cell carcinoma: post hoc analysis from Eastern Cooperative Oncology Group‐American College of Radiology Imaging Network (ECOG‐ACRIN) E2805 (2021)

Adjuvant therapy with sunitinib or sorafenib did not show an improvement in DFS or OS in patients with sRCC.
Synthesis, self‐assembly and reversible healing of supramolecular perfluoropolyethers (2013)

ABSTRACT The synthesis and thermomechanical properties of a novel class of self‐healing perfluoropolyethers (PFPEs) is reported. By decoration of 2‐ureido‐4[1 H ]‐pyrimidone end groups on the termini of low molar mass PFPE, the formation of supramolecular polymers and networks held together via hydrogen bonding associations was achieved. These novel supramolecular polymer materials exhibit a combination of enhanced modulus and elasticity, along with self‐healing properties, where rapid self‐healing time was demonstrated using dynamic rheological measurements. These types of supramolecular PFPEs are anticipated to be useful for a number of emerging areas in lubrication. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 3598–3606
Single chip system for bio-data acquisition, digitization and telemetry (2002)

A custom IC has been developed for the acquisition, digitization and telemetry of biological signals in the laboratory. This single chip system consists of a preamplifier, analog to digital converter and frequency shift keyed telemetry. The IC is 2.25 mm/spl times/2.25 mm and consumes 10 mW of power at a power supply voltage of 2.5 V. Data can be transmitted several meters. No off chip components are required except a miniature battery and a straight wire antenna as short as 2 cm. The IC is fabricated in a standard digital CMOS process without a second level of poly-silicon; current mode techniques are used to overcome the lack of linear capacitors.
CAMを付加した超並列SIMDプロセッサによるAES処理高速化手法 (1) : 暗号化方法 (2007)

近年,マルチメディアの分野において,H.264などの高品質な標準規格が次々と出現している.従来に比べ極めて短い期間で規格が変更されていくため,プログラマブルでハイパフォーマンスなVLSIが必要となる.この要求を満たすものとして,我々が開発している超並列SIMDプロセッサがある.また,インターネットの普及に伴い,近年,プライバシー保護などセキュリティに関して注目が集まっている.そのため,暗号技術の必要性が次第に高まっている.本論文では,超並列SIMDプロセッサのプログラマブル性を利用し,マルチメディア処理に用いたものと同様のアーキテクチャで,暗号化アルゴリズムの代表的なAESを処理する方法を提案し,シミュレーションによって評価を行った.その結果,DSPなどと比較を行い有効性が示された.
Production of GFRP air pipes using lightweight gypsum patterns removable in a recyclable way (2019)

Nowadays every industrial company needs to decrease the materials waste and increase their recyclability, especially in the composite manufacturing field, where the environmental effects are a relevant aspect. In order to produce high quality composite pipes via autoclave with high flexibility in terms of producible shapes, an interesting solution is the use of gypsum as material for the patterns. In this case, the easiest and fastest procedure to remove the gypsum patterns would through its immersion in water involving large amount of wasted gypsum to dumps. Therefore, this paper aims to make more eco-friendly the production of GFRP air pipes by reducing the raw material and to make in the same time faster and more recyclable the removing process of the gypsum patterns. For this purpose, a vegetable protein with foaming power was added to the gypsum mixture in order to produce lighter gypsum and reduce the raw material. In addition, to remove the gypsum patterns also allowing their recyclability, an innovative vibration technique was proposed. In this technique, a vibration load was applied to the gypsum pattern in order to destroy it without damage the GFRP sample. The gypsum pieces are then available for the recycling, decreasing the amount of wasted gypsum to dumps. The feasibility of the process was investigated and the mechanical properties in terms of flexural and compression strength, before and after a recycle for both the conventional gypsum and the foamed ones, were studied.
Tinnitus Suppression by Intracochlear Electrical Stimulation in Single Sided Deafness – A Prospective Clinical Trial: Follow-Up (2016)

TrialRegister.nl NTR3374.
Thermochromic Properties of Mixture Systems of Octadecylphosphonic Acid and Fluoran Dye (1994)

We have examined the thermochromic behavior of thin films formed by mixing a fluoran dye (FD: 2 ′ -( o -chloroanilino)-6 ′ -di- n -butylaminospiro[isobenzofuran-1(3 H ),9 ′ -[9 H ]xanthene]-3-one) and octadecylphosphonic acid (P18). The coloring and discoloring states were revealed to be controllable by changing the rate of cooling from the colored mixture liquid ( 100°C); quenching at 0°C maintained the solidified colored state, yet discoloring occurred after slow cooling at the rate of 4°C/min. We confirmed by X-ray diffraction and FT-IR spectra that the solidified colored state is produced by formation of the supramolecules, in which seven molecules of P18 and one molecule of FD combined, whose aggregates are in a lamellar structure. In the discoloring state, the supramolecule is decomposed to P18 and FD due to the fractional crystallization of P18.
Plasma extracellular vesicle proteins as promising noninvasive biomarkers for diagnosis of idiopathic pulmonary fibrosis (2023)

High-resolution computed tomography (HRCT) imaging is critical for diagnostic evaluation of Idiopathic Pulmonary Fibrosis (IPF). However, several other interstitial lung diseases (ILDs) often exhibit radiologic pattern similar to IPF on HRCT making the diagnosis of the disease difficult. Therefore, biomarkers that distinguish IPF from other ILDs can be a valuable aid in diagnosis. Using mass spectrometry, we performed proteomic analysis of plasma extracellular vesicles (EVs) in patients diagnosed with IPF, chronic hypersensitivity pneumonitis, nonspecific interstitial pneumonitis, and healthy subjects. A five-protein signature was identified by lasso regression and was validated in an independent cohort using ELISA. The five-protein signature derived from mass spectrometry data showed an area under the receiver operating characteristic curve of 0.915 (95%CI: 0.819-1.011) and 0.958 (95%CI: 0.882-1.034) for differentiating IPF from other ILDs and from healthy subjects, respectively. Stepwise backwards elimination yielded a model with 3 and 2 proteins for discriminating IPF from other ILDs and healthy subjects, respectively, without compromising diagnostic accuracy. In summary, we discovered and validated EV protein biomarkers for differential diagnosis of IPF in independent cohorts. Interestingly, the biomarker panel could also distinguish IPF and healthy subjects with high accuracy. The biomarkers need to be evaluated in large prospective cohorts to establish their clinical utility.
ChemInform Abstract: Silica‐Immobilized Second Generation Hoveyda—Grubbs: A Convenient, Recyclable and Storageable Heterogeneous Solid Catalyst. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Improvement of Stearidonic Acid Production in OleaginousSaccharomyces cerevisiae (2009)

Rat Delta6 desaturase was introduced in "oleaginous" Saccharomyces cerevisiae genetically modified by the snf2 disruption, DGA1 overexpression, and LEU2 expression to improve stearidonic acid (18:4n-3 (Delta6, 9, 12, 15)) production. When this transformed yeast was cultured in the presence of 0.7 g/l alpha-linolenic acid for 7 d, 0.4 g of alpha-linolenic acid was accumulated and 44 mg of stearidonic acid was produced, mainly as a triacylglycerol in the 1 liter broth.
The impact of increasing interbody fusion levels at the fractional curve on lordosis, curve correction, and complications in adult patients with scoliosis (2020)

More levels of interbody fusion resulted in increased lordosis, scoliosis curve correction, and fractional curve correction. However, additional levels of interbody fusion up to 3 levels did not result in more postoperative complications or morbidity. ALIF resulted in a greater lumbar lordosis increase than TLIF, but ALIF had higher revision surgery rates.
Mosaic Copy Number Variation in Human Neurons (2013)

We used single-cell genomic approaches to map DNA copy number variation (CNV) in neurons obtained from human induced pluripotent stem cell (hiPSC) lines and postmortem human brains. We identified aneuploid neurons, as well as numerous subchromosomal CNVs in euploid neurons. Neurotypic hiPSC-derived neurons had larger CNVs than fibroblasts, and several large deletions were found in hiPSC-derived neurons but not in matched neural progenitor cells. Single-cell sequencing of endogenous human frontal cortex neurons revealed that 13 to 41% of neurons have at least one megabase-scale de novo CNV, that deletions are twice as common as duplications, and that a subset of neurons have highly aberrant genomes marked by multiple alterations. Our results show that mosaic CNV is abundant in human neurons.
Atomic Force Microscopy and Voltammetric Investigation of Quadruplex Formation between a Triazole-Acridine Conjugate and Guanine-Containing Repeat DNA Sequences (2015)

The interactions of the Tetrahymena telomeric repeat sequence d(TG4T) and the polyguanylic acid (poly(G)) sequence with the quadruplex-targeting triazole-linked acridine ligand GL15 were investigated using atomic force microscopy (AFM) at a highly oriented pyrolytic graphite and voltammetry at a glassy carbon electrode. GL15 interacted with both sequences, in a time dependent manner, and G-quadruplex formation was detected. AFM showed the adsorption of quadruplexes as small d(TG4T) and poly(G) spherical aggregates and large quadruplex-based poly(G) assemblies, and voltammetry showed the decrease and disappearance of GL15 and guanine oxidation peak currents and appearance of the G-quadruplex oxidation peak. The GL15 molecule strongly stabilized and accelerated G-quadruplex formation in both Na(+) and K(+) ion-containing solution, although only K(+) promoted the formation of perfectly aligned tetra-molecular G-quadruplexes. The small-molecule complex with the d(TG4T) quadruplex is discrete and approximately globular, whereas the G-quadruplex complex with poly(G) is formed at a number of points along the length of the polynucleotide, analogous to beads on a string.
Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation (2018)

Cell-free DNA (cfDNA) released from damaged or dead cells can activate DNA sensors that exacerbate the pathogenesis of rheumatoid arthritis (RA). Here we show that ~40 nm cationic nanoparticles (cNP) can scavenge cfDNA derived from RA patients and inhibit the activation of primary synovial fluid monocytes and fibroblast-like synoviocytes. Using clinical scoring, micro-CT images, MRI, and histology, we show that intravenous injection of cNP into a CpG-induced mouse model or collagen-induced arthritis rat model can relieve RA symptoms including ankle and tissue swelling, and bone and cartilage damage. This culminates in the manifestation of partial mobility recovery of the treated rats in a rotational cage test. Mechanistic studies on intracellular trafficking and biodistribution of cNP, as well as measurement of cytokine expression in the joints and cfDNA levels in systemic circulation and inflamed joints also correlate with therapeutic outcomes. This work suggests a new direction of nanomedicine in treating inflammatory diseases.
Design of a Sub-Picosecond Jitter with Adjustable-Range CMOS Delay-Locked Loop for High-Speed and Low-Power Applications (2016)

A Delay-Locked Loop (DLL) with a modified charge pump circuit is proposed for generating high-resolution linear delay steps with sub-picosecond jitter performance and adjustable delay range. The small-signal model of the modified charge pump circuit is analyzed to bring forth the relationship between the DLL's internal control voltage and output time delay. Circuit post-layout simulation shows that a 0.97 ps delay step within a 69 ps delay range with 0.26 ps Root-Mean Square (RMS) jitter performance is achievable using a standard 0.13 µm Complementary Metal-Oxide Semiconductor (CMOS) process. The post-layout simulation results show that the power consumption of the proposed DLL architecture's circuit is 0.1 mW when the DLL is operated at 2 GHz.
Monoclonal antibodies against Rous sarcoma virus integrase protein exert differential effects on integrase function in vitro (1995)

We have prepared and characterized several monoclonal antibodies (MAbs) against the Rous sarcoma virus integrase protein (IN) with the aim of employing these specific reagents as tools for biochemical and biophysical studies. The interaction of IN with the purified MAbs and their Fab fragment derivatives was demonstrated by Western blot (immunoblot), enzyme-linked immunosorbent assay, and size exclusion chromatography. A series of truncated IN proteins was used to determine regions in the protein important for recognition by the antibodies. The MAbs described here recognize epitopes that lie within the catalytic core region of IN (amino acids 50 to 207) and are likely to be conformational. A detailed functional analysis was carried out by investigating the effects of Fab fragments as well as of intact MAbs on the activities of IN in vitro. These studies revealed differential effects which fall into three categories. (i) One of the antibodies completely neutralized the processing as well as the joining activity and also reduced the DNA binding capacity as determined by a nitrocellulose filter binding assay. On the other hand, this MAb did not abolish the cleavage-ligation reaction on a disintegration substrate and the nonspecific cleavage of DNA by IN. The cleavage pattern generated by the IN-MAb complex on various DNA substrates closely resembled that produced by mutant IN proteins which show a deficiency in multimerization. Preincubation of IN with substrate protected the enzyme from inhibition by this antibody. (ii) Two other antibodies showed a general inhibition of all IN activities tested. (iii) In contrast, a fourth MAb stimulated the in vitro joining activity of IN. Size exclusion chromatography demonstrated that IN-Fab complexes from representatives of the three categories of MAbs exhibit different stoichiometric compositions that suggest possible explanations for their contrasting effects and may provide clues to the relationship between the structure and function of IN.
A potential role of fatty acid binding protein 4 in the pathophysiology of autism spectrum disorder (2020)

Autism spectrum disorder is a neurodevelopmental disorder characterized by difficulties in social communication and interaction, as well as repetitive and characteristic patterns of behaviour. Although the pathogenesis of autism spectrum disorder is unknown, being overweight or obesity during infancy and low weight at birth are known as risks, suggesting a metabolic aspect. In this study, we investigated adipose tissue development as a pathophysiological factor of autism spectrum disorder by examining the serum levels of adipokines and other metabolic markers in autism spectrum disorder children (<i>n</i> = 123) and typically developing children (<i>n</i> = 92) at 4-12 years of age. Among multiple measures exhibiting age-dependent trajectories, the leptin levels displayed different trajectory patterns between autism spectrum disorder and typically developing children, supporting an adipose tissue-dependent mechanism of autism spectrum disorder. Of particular interest, the levels of fatty acid binding protein 4 (FABP4) were significantly lower in autism spectrum disorder children than in typically developing subjects, at preschool age (4-6 years old: <i>n</i> = 21 for autism spectrum disorder and <i>n</i> = 26 for typically developing). The receiver operating characteristic curve analysis discriminated autism spectrum disorder children from typically developing children with a sensitivity of 94.4% and a specificity of 75.0%. We re-sequenced the exons of the <i>FABP4</i> gene in a Japanese cohort comprising 659 autism spectrum disorder and 1000 control samples, and identified two rare functional variants in the autism spectrum disorder group. The Trp98Stop, one of the two variants, was transmitted to the proband from his mother with a history of depression. The disruption of the <i>Fabp4</i> gene in mice evoked autism spectrum disorder-like behavioural phenotypes and increased spine density on apical dendrites of pyramidal neurons, which has been observed in the postmortem brains of autism spectrum disorder subjects. The <i>Fabp4</i> knockout mice had an altered fatty acid composition in the cortex. Collectively, these results suggest that an 'adipo-brain axis' may underlie the pathophysiology of autism spectrum disorder, with FABP4 as a potential molecule for use as a biomarker.
Can Generative Large Language Models Perform ASR Error Correction? (2023)

ASR error correction is an interesting option for post processing speech recognition system outputs. These error correction models are usually trained in a supervised fashion using the decoding results of a target ASR system. This approach can be computationally intensive and the model is tuned to a specific ASR system. Recently generative large language models (LLMs) have been applied to a wide range of natural language processing tasks, as they can operate in a zero-shot or few shot fashion. In this paper we investigate using ChatGPT, a generative LLM, for ASR error correction. Based on the ASR N-best output, we propose both unconstrained and constrained, where a member of the N-best list is selected, approaches. Additionally, zero and 1-shot settings are evaluated. Experiments show that this generative LLM approach can yield performance gains for two different state-of-the-art ASR architectures, transducer and attention-encoder-decoder based, and multiple test sets.