gebhart/patrepeval huggingface dataset:
Sciences des données (2020)

et vido (https://www.college-de-france.fr/site/ stephane-mallat/inaugural-lecture-2017-2018.htm).
Complex Iridium(III) Salts: Luminescent Porous Crystalline Materials (2010)

Let your light shine: A new class of noncovalently linked crystalline porous materials is based on luminescent iridium complexes. Pairs complexes possessing different emission colors and complementary charges form complex salts. The crystalline materials form 3D porous motifs, and the emission color can be tuned by inclusion of a solvent or by selective quenching of one of the components of the crystal. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Measurement and modeling of charge feedthrough in n-channel MOS analog switches (1985)

Charge feedthrough in analog MOS switches has been measured. The dependence of the feedthrough voltage on the input and tub voltages, device dimensions, and load capacitances was characterized. Most importantly, it was observed that the feedthrough voltage decreases linearly with the input voltage. The significance of this observation when considering harmonic distortion in sample-and-hold circuits is discussed. A first-order computer simulation based on the quasi-static small-signal MOSFET capacitances shows good agreement with experimental results.
Localization of internal pools of membrane glycoproteins involved in platelet adhesive responses. (1986)

To investigate the existence of intracellular pools of membrane glycoproteins involved in platelet adhesive reactions, the authors have studied the distribution of glycoprotein (GP) Ib and IIb/IIIa by immunofluorescence and immunoelectron microscopy. Studies on whole cells and frozen thick sections revealed a rim pattern of fluorescence for GPIb and GPIIb/IIIa consistent with a surface distribution. In addition, extensive staining occupying the entire cell interior was observed for anti-GPIIb/IIIa, whereas anti-GPIb revealed staining of large intracellular structures that contained no stainable fibrinogen. On the ultrastructural level, the extracellular face of the plasma membrane and the intraluminal face of vacuolar structures were stained with both anti-GPIb and anti-GPIIb/IIIa. Additionally, GPIIb/IIIa antigen was localized to alpha-granule membranes. To determine whether alpha-granule GPIIb/IIIa could be transported to the cell surface, the authors employed a calcium-dependent monoclonal anti-GPIIb/IIIa antibody. Incubation of platelets with EGTA at 37 C abolished staining of plasma membrane and vacuolar but not alpha-granule GPIIb/IIIa. Recalcification of these cells failed to restore the epitope; however, thrombin treatment of recalcified cells reconstituted surface staining with a concurrent loss of internal staining. These data suggest that GPIIb/IIIa is present in alpha-granule membranes and may be transported to the cell surface in response to thrombin treatment. In addition, both GPIb and GPIIb/IIIa antigens are present in intracellular membrane-bounded vacuolar structures which are closed to antibody probes in fixed cells. Redistribution of these internal pools of adhesive protein "receptors" may participate in the regulation of platelet adhesive properties.
High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3 (2018)

T-cell immunoglobulin and mucin domain containing protein-3 (TIM-3) is an important immune regulator. Here, we describe a novel high resolution (1.7 Å) crystal structure of the human (h)TIM-3 N-terminal variable immunoglobulin (IgV) domain with bound calcium (Ca<sup>++</sup>) that was confirmed by nuclear magnetic resonance (NMR) spectroscopy. Significant conformational differences were observed in the B-C, C'-C″ and C'-D loops of hTIM-3 compared to mouse (m)TIM-3, hTIM-1 and hTIM-4. Further, the conformation of the C-C' loop of hTIM-3 was notably different from hTIM-4. Consistent with the known metal ion-dependent binding of phosphatidylserine (PtdSer) to mTIM-3 and mTIM-4, the NMR spectral analysis and crystal structure of Ca<sup>++</sup>-bound hTIM-3 revealed that residues in the hTIM-3 F-G loop coordinate binding to Ca<sup>++</sup>. In addition, we established a novel biochemical assay to define hTIM-3 functionality as determined by binding to human carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1). These studies provide new insights useful for understanding and targeting hTIM-3.
Combining Implicit Function Learning and Parametric Models for 3D Human\n Reconstruction (2020)

Implicit functions represented as deep learning approximations are powerful\nfor reconstructing 3D surfaces. However, they can only produce static surfaces\nthat are not controllable, which provides limited ability to modify the\nresulting model by editing its pose or shape parameters. Nevertheless, such\nfeatures are essential in building flexible models for both computer graphics\nand computer vision. In this work, we present methodology that combines\ndetail-rich implicit functions and parametric representations in order to\nreconstruct 3D models of people that remain controllable and accurate even in\nthe presence of clothing. Given sparse 3D point clouds sampled on the surface\nof a dressed person, we use an Implicit Part Network (IP-Net)to jointly predict\nthe outer 3D surface of the dressed person, the and inner body surface, and the\nsemantic correspondences to a parametric body model. We subsequently use\ncorrespondences to fit the body model to our inner surface and then non-rigidly\ndeform it (under a parametric body + displacement model) to the outer surface\nin order to capture garment, face and hair detail. In quantitative and\nqualitative experiments with both full body data and hand scans we show that\nthe proposed methodology generalizes, and is effective even given incomplete\npoint clouds collected from single-view depth images. Our models and code can\nbe downloaded from http://virtualhumans.mpi-inf.mpg.de/ipnet.\n
Spectrally constrained NIR tomography for breast imaging: simulations and clinical results (2005)

A multi-spectral direct chromophore and scattering reconstruction for frequency domain NIR tomography has been implemented using constraints of the known molar spectra of the chromophores and a Mie theory approximation for scattering. This was tested in a tumor-simulating phantom containing an inclusion with higher hemoglobin, lower oxygenation and contrast in scatter. The recovered images were quantitatively accurate and showed substantial improvement over existing methods; and in addition, showed robust results tested for up to 5% noise in amplitude and phase measurements. When applied to a clinical subject with fibrocystic disease, the tumor was visible in hemoglobin and water, but no decrease in oxygenation was observed, making oxygen saturation, a potential diagnostic indicator.
Synthesis of 2′‐Substituted MMI Linked Nucleosidic Dimers: An Optimization Study in Search of High Affinity Oligonucleotides for Use in Antisense Constructs (2004)

The synthesis of a series of methylene(methylimino) (MMI) linked oligodeoxyribonucleotide dimers modified at the 2'-position with fluoro and/or methoxy groups and their incorporation into different sequences has been accomplished. From these dimers, bis 2'-OMe MMI dimer was selected for further studies based on its synthetic accessibility and the increased thermodynamic stability conferred upon oligonucleotides incorporating this modification.
Mesenteriale Vaskularisation maligner Nierentumoren (1975)

Three angiographic observations showing partial mesenteric vascularisation of renal tumours were made. Problems in diagnosis and therapy arising from this are discussed.
Mesocosm‐Scale Evaluation of Faunal and Microbial Communities of Aerated and Unaerated Leachfield Soil (2006)

Aeration improves the capacity of leachfields to decontaminate and reduce the nutrient load of wastewater. To gain a better understanding of the effects of aeration, we examined the faunal and microbial communities of septic system leachfield soil (0-4 and 4-13 cm) using replicated (n = 3) mesocosms that were actively aerated (AIR) or unaerated (LEACH). Protozoa were 40 to 140 times more abundant in AIR than in LEACH soil. No nematodes were found in LEACH soil, whereas AIR soil contained 5 to 14 x 10(3) nematodes (all bacteriovores) kg(-1). Active microbial biomass was four to five times higher in AIR than LEACH soil. Proteobacteria and actinomycetes/sulfate-reducing bacteria constituted a higher proportion of the community in AIR soil, whereas anaerobic Gram-negative bacteria/firmicutes were more prominent in LEACH soil. Ratios of prokaryotic to eukaryotic phospholipid fatty acids (PLFAs) were higher in LEACH soil, as were membrane stress index values, whereas the starvation index was higher in AIR soil. Community-level physiological profiles showed that 29 and 30 different substrates were used for growth by LEACH and AIR soil microorganisms, respectively. The AIR soil had more microorganisms capable of growing on 10 substrates, whereas growth on two substrates was higher in LEACH soil. Polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) analysis of 16S rRNA gene fragments revealed greater diversity of dominant phylotypes in AIR than LEACH soil, with communities separated by treatment. Aerated leachfield soil had a larger and more diverse faunal and microbial community than unaerated soil, possibly due to differences in the type and availability of electron acceptors.
Impact of Correlated Failures in 5G Dual Connectivity Architectures for URLLC Applications (2019)

Achieving end-to-end ultra-reliability and resiliency in mission critical communications is a major challenge for future wireless networks. Dual connectivity has been proposed by 3GPP as one of the viable solutions to fulfill the reliability requirements. However, the potential correlation in failures occurring over different wireless links is commonly neglected in current network design approaches. In this paper, we investigate the impact of realistic correlation among different wireless links on end-to-end reliability for two selected architectures from 3GPP. In ultra-reliable use-cases, we show that even small values of correlation can increase the end-to-end error rate by orders of magnitude. This may suggest alternative feasible architecture designs and paves the way towards serving ultra-reliable communications in 5G networks.
Shoulder Arthroplasty Without a Rotator Cuff (2003)

Patients with a glenohumeral arthritis and a deficient rotator cuff represent a therapeutic challenge. In 1987, Paul M. C ram mot, MD introduced a new reverse design to treat this patient population. This reverse design shoulder prosthesis has a cup placed within the proximal humerus and a hemisphere fixated to the glenoid. This prosthetic design relies on the deltoid to provide active elevation. In this issue, Dr Gilles Walch, a leading international expert in shoulder surgery, shares his views on the reverse design prosthesis. Dr Walch has had vast experience and reports a high success rate with the implant, which is currently under IDE study in the United States.
AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis (2018)

Epigenetic heterogeneity is emerging as a feature of tumors. In diffuse large B-cell lymphoma (DLBCL), increased cytosine methylation heterogeneity is associated with poor clinical outcome, yet the underlying mechanisms remain unclear. Activation-induced cytidine deaminase (AICDA), an enzyme that mediates affinity maturation and facilitates DNA demethylation in germinal center (GC) B cells, is required for DLBCL pathogenesis and linked to inferior outcome. Here we show that AICDA overexpression causes more aggressive disease in BCL2-driven murine lymphomas. This phenotype is associated with increased cytosine methylation heterogeneity, but not with increased AICDA-mediated somatic mutation burden. Reciprocally, the cytosine methylation heterogeneity characteristic of normal GC B cells is lost upon AICDA depletion. These observations are relevant to human patients, since DLBCLs with high AICDA expression manifest increased methylation heterogeneity vs. AICDA-low DLBCLs. Our results identify AICDA as a driver of epigenetic heterogeneity in B-cell lymphomas with potential significance for other tumors with aberrant expression of cytidine deaminases.
Regulation of Lipocalin-type Prostaglandin D Synthase Gene Expression by Hes-1 through E-box and Interleukin-1β via Two NF-κB Elements in Rat Leptomeningeal Cells (2003)

The promoter function of the rat lipocalin-type prostaglandin D synthase (L-PGDS) gene was characterized in primary cultures of leptomeningeal cells prepared from the neonatal rat brain. Luciferase reporter assays with deletion and site-directed mutation of the promoter region (-1250 to +77) showed that an AP-2 element at -109 was required for activation and an E-box at +57, for repression. Binding of nuclear factors to each of these cis-elements was demonstrated by an electrophoretic mobility shift assay. Several components of the Notch-Hes signaling pathway, Jagged, Notch1, Notch3, and Hes-1, were expressed in the leptomeningeal cells. Human Hes-1 co-expressed in the leptomeningeal cells bound to the E-box of the rat L-PGDS gene, and repressed the promoter activity of the rat L-PGDS gene in a dose-dependent manner. The L-PGDS gene expression was up-regulated slowly by interleukin-1 beta to the maximum level at 24 h. The reporter assay with deletion and mutation revealed that two NF-kappa B elements at -1106 and -291 were essential for this up-regulation. Binding of two NF-kappa B subunits, p65 and c-Rel, to these two NF-kappa B elements occurred after the interleukin-1 beta treatment. Therefore, the L-PGDS gene is the first gene identified as the target for the Notch-Hes signal through the E-box among a variety of genes involved in the prostanoid biosynthesis, classified to the lipocalin family, and expressed in the leptomeninges. Moreover, the L-PGDS gene is a unique gene that is activated slowly by the NF-kappa B system.
Hydrogen Charging Methods to Low Alloy Steel Simulating Atmospheric and High Pressure Gaseous Hydrogen Environments (2014)

Appropriate hydrogen charging methods were investigated to simulate hydrogen absorption from actual environments where high strength steels are used. Both absorbed hydrogen concentrations and hydrogen desorption profiles were compared between various hydrogen charging tests - immersion tests, cathodic charging tests, cyclic corrosion tests (CCT) and exposure tests in high pressure gaseous hydrogen. Absorbed hydrogen was analyzed using thermal desorption analysis (TDA) after the hydrogen charging tests. It was confirmed that acid immersion tests or cathodic charging tests in NaCl solution were appropriate to simulate hydrogen absorption from CCT. Fédération Internationale de la Précontrainte (FIP) tests or cathodic charging tests in NaCl - NH4SCN solution could be used to simulate hydrogen absorption in high pressure hydrogen gas environments. Comparisons in TDA profiles showed that the ratio of strongly-trapped hydrogen and weakly-trapped hydrogen changed depending upon the total amount of absorbed hydrogen. This result means the state of hydrogen in steels, which affects hydrogen embrittlement, can change according to the amount of absorbed hydrogen. The above-mentioned hydrogen charging tests and hydrogen analysis were conducted in 15 laboratories to check the scatter of measured hydrogen concentration.
Adaptive time-frequency decompositions with matching pursuit (1994)

To compute the optimal expansion of signals in redundant dictionary of waveforms is an NP complete problem. We introduce a greedy algorithm, called matching pursuit, that performs a suboptimal expansion. The waveforms are chosen iteratively in order to best match the signal structures. Matching pursuits are general procedures to compute adaptive signal representations. With a dictionary of Gabor functions, a matching pursuit defines an adaptive time-frequency transform. We derive a signal energy distribution in the time-frequency plane, which does not include interference terms, unlike Wigner and Cohen class distributions. A matching pursuit is a chaotic map, whose attractor defines a generic noise with respect to the dictionary. We derive an algorithm that isolates the coherent structures of a signal and an application to pattern extraction from noisy signals is described.
Severe impairment of leukocyte recruitment into inflamed tissue of ppGalNAcT1-deficient mice (94.1) (2009)

Abstract P-selectin glycoprotein ligand-1 (PSGL-1) plays an important role in leukocyte recruitment. Its binding affinity to selectins is modulated by posttranslational modifications. The polypeptide N-acetylgalactosamine transferase-1 (ppGalNAcT1) initiates core-type protein O-glycosylation. To address whether the glycosylation of PSGL-1 by ppGalNAcT1 is important for leukocyte recruitment, we investigated leukocyte rolling and velocity in untreated and TNF-α treated cremaster muscles and autoperfused flow chambers comparing ppGalNAcT1-/-(Galnt1-/- ) with WT mice. In untreated and TNF-α treated Galnt1-/- mice, leukocyte rolling was significantly reduced with markedly increased rolling velocity compared to control mice. Flow chamber experiments showed that Galnt1-/- - and WT-neutrophils had the same rolling velocity on E-selectin, but the rolling velocity of Galnt1-/- -neutrophils on E-selectin/ICAM-1 was significantly elevated, suggesting that E-selectin-dependent neutrophil activation may be defective. Thioglycollate-induced peritonitis experiments with chimeric mice revealed that hematopoietic ppGalNAcT1 is important for leukocyte recruitment. These data show that the loss of ppGalNAcT1 led to reduced leukocyte rolling and recruitment and increased rolling velocity, suggesting a predominant role of ppGalNAcT1 in attaching functionally relevant O-linked glycans to PSGL-1.
Sulfonic Acid-Functionalized Zeolite Beta: Bronsted Acid Catalysts for Reactions Involving Liquid Water (2021)

The utility of zeolites in biomass upgrading reactions can be limited in cases where stronger Bronsted acidity and/or hydrophobicity are required for effective catalysis. While sulfonated solids/sulfonic acid catalysts can be used in such cases, they forego the advantageous effects of confinement that are afforded by zeolites. Here, acidity, hydrophobicity, and confinement are integrated into a solid material by functionalizing the intrapore voids of zeolite Beta with phenethyl-sulfonic acid sites (PE-Betas). These PE-Betas, along with conventional H-Betas, mesoporous phenethyl-sulfonic acid-functionalized SiO2 gel (PE-SiO2), and commercial sulfonic acid catalysts (para-toluenesulfonic acid, Nafion NR50) are evaluated in the hydroxyalkylation/alkylation reaction of 2-methylfuran with acetone. The PE-Betas show superior turnover numbers (TON) due to the combination of high acid site strength and hydrophobicity that arises from the confined PE groups. Further, the hydrophobicity and TON over PE-Betas are invariant with acid site density, showing that these materials effectively decouple the active site density–hydrophilicity relationship that is a fundamental limitation of conventional zeolites. These sulfonic acid-functionalized zeolites represent a distinct class of water-tolerant, strong Bronsted acid catalysts that may be well suited for a wide range of biomass upgrading reactions that generate stoichiometric amounts of liquid water.
Equation of State Modeling of the Solubility of CO2/C2H6 Mixtures in Cross-Linked Poly(ethylene oxide) (2015)

The solubility of gaseous mixtures of CO2 and C2H6 in cross-linked poly(ethylene oxide) (XLPEO) has been modeled over a wide range of temperatures, pressures, and compositions with the Sanchez–Lacombe lattice fluid equation of state (LF EoS). The model binary gas–polymer parameters have been determined from pure gas solubility data and kept constant with temperature and composition. Multicomponent solubility is then calculated with no additional adjustable parameters, using a fully predictive procedure. The LF EoS model describes well the mixed gas solubility behavior data over wide ranges of temperature (from −20 to 35 °C), pressure (0–20 atm), and composition. The model also allows the representation of the solubility selectivity behavior of XLPEO at different conditions, permitting an a priori determination that ethane solubility is significantly enhanced by the presence of CO2, with a consequent reduction in CO2/C2H6 solubility selectivity relative to the pure gas value. In this regard, the behavior of this rubbery polymer is opposite that of many glassy systems, in which competitive sorption is often dominant, and the solubility of the less soluble gas (i.e., C2H6 in this case) is decreased by the presence of CO2, and the CO2 solubility selectivity is enhanced with respect to the pure gas value.
Effects of Temperature on the Alignment and Electrooptical Responses of a Nematic Nanoscale Liquid Crystalline Film (2006)

The surface-induced alignment and electrooptical (EO) dynamics of a 50-nm-thick liquid crystalline (4-n-pentyl-4'-cyanobiphenyl; 5CB) film were studied at three temperatures: 25 and 33 degrees C (near the crystalline-nematic and nematic-isotropic transition temperatures, respectively) and 29 degrees C (a median temperature in the stability region of the nematic phase). The ZnSe surfaces that entrap the liquid crystal (LC) film have been polished unidirectionally to produce a grooved surface presenting nanometer-scale corrugations, a structure that induces a planar and homogeneous orientation in the nematic phase. The present work attempts to understand the influences of temperature on the surface-induced alignment and corresponding EO dynamics of the material. Step-scan time-resolved spectroscopy measurements were made to determine the rate constants for the electric-field-induced orientation and thermal relaxation of the 5CB film. The field-driven orientation rates vary sensitively with temperature across a range that spans the stability limits of the nematic phase; the relaxation rates, however, vary very little across this same temperature range. We propose that these differences in LC behavior arise as consequence of the interplay of the temperature dependence of the elastic constants, viscosity, and degree of orientational order of the LC medium. A simple theoretical model provides some understanding of these behaviors.
Biochemical changes in heat stressed promastigotes of Leishmania donovani. (1995)

On exposing promastigotes of L. donovani (Dd-8) to 34 degrees C for 30 hr, the flagella were shed, and size was decreased with 10% viability loss. The in vitro and in vivo infectivity of two forms was more or less similar. The 45Ca2+ uptake by the transformed cells was increased as compared to normal cells. Activity of 5'-nucleotidase was increased while activity of Mg(2+)-ATPase remained same. Parasite antioxidant enzymes were also significantly altered by heat shock. There was significant increase in superoxide dismutase, glutathione reductase and glutathione peroxidase. It was accompanied by decrease in ratio of reduced glutathione to oxidized glutathione.