gebhart/patrepeval huggingface dataset:
Dynamic characteristics of PdCoO2/β-Ga2O3 Schottky junctions (2020)

A high-frequency diode is an essential component in electrical circuits providing the current rectification function for AC/DC converters, radio frequency detectors, and automotive inverters. Schottky barrier diodes based on wide-bandgap semiconductors are promising for the high-frequency applications owing to short reverse recovery time that minimizes the energy dissipation during the switching. In this study, we report dynamic characteristics of Schottky junctions composed of a layered oxide metal PdCoO2 and an n-type β-Ga2O3 substrate. Rectifying current–voltage characteristics with reasonably small hysteresis were demonstrated up to a high frequency of 3 MHz in the PdCoO2/β-Ga2O3 Schottky junctions. For the on-state to off-state switching with the current ramp rate of approximately −2 × 1010 A/scm2, the reverse recovery time was as short as 11 ns. The short reverse recovery time was constantly obtained in the operation temperature range of 25–350 °C, showing low-loss switching properties of the PdCoO2/β-Ga2O3 Schottky junctions. The Schottky barrier height of ∼1.78 eV and the ideality factor of ∼1.06 were maintained after the 108-times on–off switching cycles. The fast switching with less energy dissipation and high durability of the PdCoO2/β-Ga2O3 Schottky junctions would be suitable for application in high-frequency power devices operating at high temperature.
Photoelectron spectroscopy of f-element organometallic complexes. 8. DV-X.alpha. and gas-phase UV photoelectron spectroscopic investigation of the electronic structure of tris(.eta.5-cyclopentadienyl)uranium(IV) complexes (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoelectron spectroscopy of f-element organometallic complexes. 8. DV-X.alpha. and gas-phase UV photoelectron spectroscopic investigation of the electronic structure of tris(.eta.5-cyclopentadienyl)uranium(IV) complexesAntonino Gulino, Enrico Ciliberto, Santo Di Bella, Ignazio Fragala, Afif M. Seyam, and Tobin J. MarksCite this: Organometallics 1992, 11, 10, 3248–3257Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October 1992https://pubs.acs.org/doi/10.1021/om00046a022https://doi.org/10.1021/om00046a022research-articleACS PublicationsRequest reuse permissionsArticle Views74Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Effect of Achilles Tendon Lengthening and Gastrocnemius Recession on Radiographic Tibiotalar Motion Following Total Ankle Replacement (2020)

Level III, retrospective comparative study.
Imaging for Ureteropelvic Junction Obstruction in Adults (1996)

The three goals of imaging for ureteropelvic junction (UPJ) obstruction are to determine the presence and degree of renal obstruction, to assess renal function, and to determine the cause of the problem. The diagnostic techniques are intravenous urography, which is unreliable; ultrasonography, with the addition of pulsed Doppler technology; diuretic scintigraphy; and pressure-flow studies (Whitaker test), which is the only direct clinical test of renal outflow resistance. Voiding cystography, retrograde ureteropyelography, and CT have utility in some patients. In determining the cause of obstruction, the patient often is evaluated for crossing vessels using angiography, endoluminal ultrasonography, or spiral CT. It is not possible to formulate a single algorithm for radiographic evaluation of suspected UPJ obstruction, but in the average adult patient, urography and diuretic scintigraphy are sufficient.
SUMOylation controls the rapid transcriptional reprogramming induced by anthracyclines in Acute Myeloid Leukemias (2022)

Abstract Genotoxicants have been used for decades as front-line therapies against cancer on the basis of their DNA-damaging actions. However, some of their non-DNA-damaging effects are also instrumental for killing dividing cells. We report here that the anthracycline Daunorubicin (DNR), one of the main drugs used to treat Acute Myeloid Leukemia (AML), induces broad transcriptional changes in AML cells before cell death induction. The regulated genes are particularly enriched in genes controlling cell proliferation and death, as well as inflammation and immunity. These transcriptional changes are preceded by DNR-dependent de SUMOylation of chromatin proteins, which limits both the positive and negative effects of DNR on transcription. Quantitative proteomics shows that proteins that are de SUMOylated in response to DNR are mostly transcription factors, transcriptional co-regulators and chromatin organizers. Among them, the CCCTC-binding factor CTCF is highly enriched at SUMO-binding sites found in cis -regulatory regions. This is notably the case at the promoter of the DNR-induced NFKB2 gene. Its induction is preceded by a SUMO-dependent reconfiguration of chromatin loops engaging its CTCF- and SUMO-bound promoter with distal cis -regulatory regions. Altogether, our work suggests that one of the earliest effects of DNR in AML cells is a SUMO-dependent transcriptional reprogramming.
ChemInform Abstract: Enhancement of Electrical Conductivity of Polycrystalline β‐PbO by Exposure to Ozone Gas at Room Temperature. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
CRISPR-Cas9–based treatment of myocilin-associated glaucoma (2017)

Primary open-angle glaucoma (POAG) is a leading cause of irreversible vision loss worldwide, with elevated intraocular pressure (IOP) a major risk factor. Myocilin (<i>MYOC</i>) dominant gain-of-function mutations have been reported in ∼4% of POAG cases. <i>MYOC</i> mutations result in protein misfolding, leading to endoplasmic reticulum (ER) stress in the trabecular meshwork (TM), the tissue that regulates IOP. We use CRISPR-Cas9-mediated genome editing in cultured human TM cells and in a MYOC mouse model of POAG to knock down expression of mutant MYOC, resulting in relief of ER stress. In vivo genome editing results in lower IOP and prevents further glaucomatous damage. Importantly, using an ex vivo human organ culture system, we demonstrate the feasibility of human genome editing in the eye for this important disease.
Large area CCD based imaging system for mammography (2003)

The authors have recently developed a digital X-ray imaging system based on a high resolution scintillator screen optically coupled to a specially designed large area CCD for use in mammographic procedures. The CCD consists of a 7 K/spl times/4 K array of 12 /spl mu/m pixels, measuring 88.2 mm/spl times/51 mm and operated at room temperature, cooled only by ambient air circulation. With 12 /spl mu/m pixels, the resulting limiting Nyquist frequency is 41.6 lp/mm. The readout electronics and software are designed to capture images with the full CCD resolution as well as with binning. Depending on the requirements of the application, the CCD may be binned in the 2/spl times/2 or the 4/spl times/4 configuration. Since the time required to read 28 million pixels is large, binning provides an option for rapid image acquisition at a reduced resolution. A fiberoptic faceplate is optically bonded to the CCD to simplify coupling of scintillator screens to the sensor. One important feature of the system is the lack of a fiberoptic taper, making the system smaller and easier to handle or move. Structured CsI(Tl) scintillator screens developed at RMD Inc., were used for the system evaluation. This paper discusses the system design, the characterization of the CCD sensor as well as the imaging performance of the system using mammography phantoms.
Optical Techniques for Microscopic Imaging of Semiconductor and Ceramic Layers (2001)

Defection of material contaminates and material defects on microelectronic-grade silicon wafers is necessary to ensure high-quality material before beginning the value-added processing.1 Structural properties of thin films and subsurface layers are important for material characterization and phase identification.2 We report on our recent results on applying different optical techniques for microscopic imaging of semiconductor and ceramic layers.
Biochemical Characterization and Crystal Structure of a Dim1 Family Associated Protein:  Dim2 (2005)

The U4/U6*U5 tri-snRNP complex is the catalytic core of the pre-mRNA splicing machinery. The thioredoxin-like protein hDim1 (U5-15 kDa) constitutes an essential component of the U5 particle, and its functions have been reported to be highly conserved throughout evolution. Recently, the Dim1-like protein (DLP) family has been extended to other proteins harboring similar sequence motifs. Here we report the biochemical characterization and crystallographic structure of a 149 amino acid protein, hDim2, which shares 38% sequence identity with hDim1. The crystallographic structure of hDim2 solved at 2.5 A reveals a classical thioredoxin-fold structure. However, despite the similarity in the thioredoxin fold, hDim2 differs from hDim1 in many significant features. The structure of hDim2 contains an extra alpha helix (alpha3) and a beta strand (beta5), which stabilize the protein, suggesting that they may be involved in interactions with hDim2-specific partners. The stability and thermodynamic parameters of hDim2 were evaluated by combining circular dichroism and fluorescence spectroscopy together with chromatographic and cross-linking approaches. We have demonstrated that, in contrast to hDim1, hDim2 forms stable homodimers. The dimer interface is essentially stabilized by electrostatic interactions and involves tyrosine residues located in the alpha3 helix. Structural analysis reveals that hDim2 lacks some of the essential structural motifs and residues that are required for the biological activity and interactive properties of hDim1. Therefore, on the basis of structural investigations we suggest that, in higher eukaryotes, although both hDim1 and hDim2 are involved in pre-mRNA splicing, the two proteins are likely to participate in different multisubunit complexes and biological processes.
Electrical Characterization of Capacitors with AVD-Deposited Hafnium Silicates as High-k Gate Dielectric (2005)

We discuss the electrical properties of hafnium silicates with various composition deposited by atomic vapor deposition (AVD) as metal-oxide-semiconductor (MOS) capacitors. The deposited layers demonstrate well-behaved capacitance as function of gate voltage curves with a leakage as low as 5×10−2 for an equivalent oxide thickness (EOT) of . The permittivity (-value) ranges from 6 to 14 depending on the composition of the hafnium silicate. Flatband voltage depends on the composition (and thickness) and varies between and , from which we calculated the amount of net charge in the layer, between ×1011 and . Postdeposition treatments at in or shift the position up to , together with a change of the amount of net charge. Fine-tuning the deposition and composition might nullify the net charge contribution in the layers.
A Concise Total Synthesis of Saliniketal B (2010)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionA Concise Total Synthesis of Saliniketal BJun Liu and Jef K. De Brabander*Cite this: J. Am. Chem. Soc. 2010, 132, 23, 8223Publication Date (Web):May 19, 2010Publication History Published online19 May 2010Published inissue 16 June 2010https://pubs.acs.org/doi/10.1021/ja1037116https://doi.org/10.1021/ja1037116correctionACS PublicationsCopyright © 2010 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views3045Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (42 KB) Get e-Alertsclose Get e-Alerts
Introducing game and playful experiences to other application domains through personality and motivation models (2010)

We discuss the use of the PLEX playful experience model a system to introduce games design aspects into alternative application and product domains. We report an exploratory study to relate the relationships between playful experiences and real world values and personalities. The method led to a prototype model of playful experiences associated with values and personality based motivations, emotions and behavior, and could be a useful tool for playful concept creation. As consumer offerings are increasingly differentiated by the quality of the experience, our approach promises to enhance the fun, and widen the engagement, of many products and applications.
Antisense Technology: Liver Targeting and Beyond for Drug Discovery (2019)

Single-stranded phosphorothioate antisense oligonucleotides (ASOs) represent the most advanced RNA therapeutic technology today. The extensive characterization of the bio-distribution of systemically administered ASOs has established the hepatocyte as the most exploited cell type for antisense therapeutics to date for a broad range of human diseases. Beyond this initial cornerstone, further characterization of ASO subcellular trafficking has led to ligand–receptor targeting strategies and continued development of novel medicinal chemistries has supported the opportunity for ASO therapeutics across a broader range of tissue and cell compartments. Validation of novel routes of delivery has resulted also in the opening up of many new organ systems and cell types for human therapeutics.
Distinct Architecture of Lymphatic Vessels Induced by Chimeric Vascular Endothelial Growth Factor-C/Vascular Endothelial Growth Factor Heparin-Binding Domain Fusion Proteins (2007)

Vascular endothelial growth factor (VEGF)-C and VEGF-D are composed of the receptor-binding VEGF homology domain and a carboxy-terminal silk homology domain that requires proteolytic cleavage for growth factor activation. Here, we explored whether the C-terminal heparin-binding domain of the VEGF 165 or VEGF 189 isoform also containing neuropilin-binding sequences could substitute for the silk homology domain of VEGF-C. Such VEGF-C/VEGF–heparin-binding domain chimeras were produced and shown to activate VEGF-C receptors, and, when expressed in tissues via adenovirus or adeno-associated virus vectors, stimulated lymphangiogenesis in vivo. However, both chimeras induced a distinctly different pattern of lymphatic vessels when compared with VEGF-C. Whereas VEGF-C–induced vessels were initially a dense network of small diameter vessels, the lymphatic vessels induced by the chimeric growth factors tended to form directly along tissue borders, along basement membranes that are rich in heparan sulfate. For example, in skeletal muscle, the chimeras induced formation of lumenized lymphatic vessels more efficiently than wild-type VEGF-C. We conclude that the matrix-binding domain of VEGF can target VEGF-C activity to heparin-rich basement membrane structures. These properties may prove useful for tissue engineering and attempts to regenerate lymphatic vessels in lymphedema patients.
Classical and Nonclassical Antifolates as Potential Antitumor, Antipneumocystis and Antitoxoplasma Agents (1996)

Abstract: Inhibition of folate metabolizing enzymes remains a viable goal in the treatment of cancer, of bacterial infections and of opportunistic infections in patients with immune compromized systems. The clinically useful antifolates methotrexate (MTX), trimetrexate (TMQ), trimethoprim (TMP), pyrimethamine and 2D1694 (tomudex) inhibit the enzymes dihydrofolate reductase (DHFR) or thymidylate synthase (TS). The recent antitumor results obtained with tomudex and the antipneumocystis results with TMQ along with leucovorin rescue have provided significant stimulus to the synthesis and biological testing of antifolates. In addition, X-ray crystallography studies of the enzymes with computer assisted molecular modeling have allowed for significant studies in the development of novel antifolates. This review highlights recent advances in the computer assisted rational design, synthesis and biological evaluation of substituted classical and nonclassical bicyclic 6-6 and 6-5 ring fused antifolates, tricyclic 6-6-6 and 6-5-6 ring-fused antifolates and tetracyclic 6-6-6-6 ring-fused antifolates as anticancer, antipneumocystis and antitoxoplasma agents.
OTU-019 Pancreatic enzyme supplementation is associated with improved survival in inoperable pancreatic cancer (2018)

<h3>Introduction</h3> In the UK, 85% of pancreatic cancer (PC) patients are inoperable at presentation with a median survival of 6–9 months1. BSG guidelines recommend that patients with PC should receive pancreatic enzyme supplementation to maintain bodyweight and improve quality of life1. It is not known whether pancreatic enzyme supplementation prolongs survival. In this study, we examined the impact of pancreatic enzyme supplementation in inoperable pancreatic cancer. <h3>Methods</h3> This was a single-centre retrospective study between January 2016 and June 2017. Consecutive patients deemed inoperable in the MDT were identified. Patients were subdivided in two cohorts, pancreatic enzyme supplement (PES) and Non-PES. Date of diagnosis was determined by the date of cross-sectional imaging. Use of pancreatic enzymes was determined through patient summary care records. All cases were followed up from the date of diagnosis until the date of death or censor date (31st December 2017). Primary outcomes were all-cause mortality. <h3>Results</h3> 62 patients were included (51 had histological confirmation, 11 were radiological diagnosis). Adenocarcinoma was the commonest histological finding. Anatomical distribution of tumours was – head/uncinate (27), neck (5), body (18) and tail (12). MPD dilatation was noted in 33 patients. The mean age among the PES and Non-PES groups were comparable at 70.9 (±9.9) and 72.2 (±9.5) years respectively. 48% were female in PES group compared with 40% in non-PES group. Median follow up was 133 days (IQR 187). Unadjusted median survival days in PES group was 221 [95% CI 107.4, 334.6] compared with 61 [95% CI 35.5, 86.5] in non-PES group. Cox regression models were fitted to adjust for effects of baseline characteristics. Survival was significantly better in PES group (Log Rank p=0.004) than that seen in non-PES group (figure 1). The survival difference remained significant after adjusting for gender, age, histology of pancreatic cancer, neutrophil to lymphocyte ratio and presenting body-mass index (n=53). Lack of pancreatic enzyme supplementation was associated with significant mortality risk, adjusted hazard ratio of 2.7 [95% CI 1.38, 5.31; p=0.004]. 21 (78%) and 17 (49%) patients in PES group (n=27) and non-PES group respectively were treated with palliative chemotherapy and the rest were treated with best supportive care. <h3>Conclusions</h3> Our study concludes that pancreatic enzyme supplementation is associated with improved survival in inoperable pancreatic cancer. Further prospective studies are required to confirm our findings.
Morphology-Dependent Electronic Properties in Cross-Linked (P3HT-b-P3MT) Block Copolymer Nanostructures (2014)

Combined Kelvin probe force microscopy and wavelength-resolved photoluminescence measurements on individual pre- and post-cross-linked poly(3-hexylthiophene)-b-poly(3-methyl alcohol thiophene) (P3HT-b-P3MT) nanofibers have revealed striking differences in their optical and electronic properties driven by structural perturbation of the crystalline aggregate nanofiber structures after cross-linking. Chemical cross-linking from diblock copolymer P3HT-b-P3MT using a hexamethylene diisocyanate cross-linker produces a variety of morphologies including very small nanowires, nanofiber bundles, nanoribbons, and sheets, whose relative abundance can be controlled by reaction time and cross-linker concentration. While the different cross-linked morphologies have almost identical photophysical characteristics, KPFM measurements show that the surface potential contrast, related to the work function of the sample, depends sensitively on nanostructure morphology related to chain-packing disorder.
Brain biocompatibility of a biodegradable controlled release polymer consisting of anhydride copolymer of fatty acid dimer and sebacic acid (1992)

The development of new biodegradable polymers (e.g. PCPP-SA) has allowed the prolonged controlled release of lipid soluble chemotherapeutic agents in the laboratory and clinically. In order to optimize this approach, a new polymer has been developed (the copolymer of fatty acid dimer and sebacic acid p[FAD-SA]) to release water soluble agents. In this study we sought to determine the safety and biocompatibility of this new polymer in the brain. We compared the tissue reaction to this polymer to the reaction observed with oxidized cellulose (SurgicelR) and with absorbable gelatin sponge (GelfoamR). Fifty-six adult Fischer 344 rats were assigned to 1 of 7 groups and underwent bilateral 3 mm burr holes. Neurological or behavioral changes were assessed daily and the groups were killed sequentially on postoperative days 3, 6, 10, 15, 21, 28, and 36. No neurological deficits or behavioral changes suggestive of either systemic or localized toxicity were observed in the animals implanted with the new polyanhydride. A well demarcated acute inflammatory response was seen at day 3 and 6 for p(FAD-SA) and SurgicelR implants. The inflammatory response remained well localized and resolved with total degradation of the polymer by day 36. The localized reaction evoked by this polymer was comparable to the one of the previously studied biodegradable polymers (PCPP-SA) and to the response to commonly used surgical hemostatic materials such as SurgicelR. The biodegradable copolymer of fatty acid dimer and sebacic acid may play an important role in drug delivery to the brain by by-passing the blood-brain barrier to administer water soluble agents directly to the brain.