gebhart/patrepeval huggingface dataset:
The glucocorticoid antagonist RU38486 mimics interleukin‐1 in its sensitization to the lethal and interleukin‐6‐inducing properties of tumor necrosis factor (1992)

Although tumor necrosis factor (TNF) is undoubtedly a major mediator of the antitumor and shock-inducing activities of lipopolysaccharide (LPS), the outcome of a challenge with TNF is highly dependent on the presence or absence of other substances or conditions. We have previously shown that to obtain lethality in mice after TNF administration both TNF receptor (TNF-R) types have to be triggered. This is illustrated by the fact that recombinant human (rh) TNF, which is a selective murine (m) TNF-R55 agonist, is not lethal, whereas mTNF, which binds both mTNF-R55 and mTNF-R75, is lethal in mice. Triggering of TNF-R75 is, however, no longer needed when sensitizers such as galactosamine or low doses of LPS or interleukin (IL)-1 are also present. Here, we report that this selective species specificity of TNF is also reflected in patterns of induced IL-6: both rmTNF and rhTNF could induce considerable IL-6 peak levels in the plasma (up to 10 ng/ml) 2 to 3 h after TNF administration. However, only rmTNF was capable of inducing the same pattern of sustained IL-6 levels previously observed after lethal LPS doses, while rhTNF only caused induction of transient IL-6 levels, as found after nonlethal LPS doses. We also observed that the sensitizer IL-1 could complement rhTNF to induce such a sustained IL-6 induction. Since we were interested in sensitizers with a defined mechanism of action, we further investigated the effects of the glucocorticoid and progesterone inhibitor RU38486 on the lethal and IL-6-inducing properties of TNF. We observed that RU38486 closely mimicked IL-1: both had similar effects on IL-6 induction and sensitized mice to the lethal effects of TNF with comparable efficiency and kinetics. Using a monoclonal anti-IL-1R antibody, we finally observed that the effects of RU38486 were most probably not mediated by IL-1. These observations suggest that a glucocorticoid-antagonistic activity might be a key factor in the pathways leading to septic shock and that such activity could be a key target for the pharmacological manipulation of sepsis.
Production of H5-Specific Monoclonal Antibodies and the Development of a Competitive Elisa for Detection of H5 Antibodies in Multiple Species (2010)

Significance of Findings The major advantage of the cELISA is the possibility of screening a large number of sera within considerably less time in comparison to the HI assay. Therefore, the cELISA allows a rapid serological and species-independent detection of antibodies against H5 in a variety of species. Further experiments are necessary to increase the sensitivity and specificity including a ribonucleoprotein (NP) cELISA system.
Supplementary Figure 4 from Cell Surface Delivery of TRAIL Strongly Augments the Tumoricidal Activity of T Cells (2023)

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Passivity Enforcement of a Transfer Function (2006)

Passivity of the identified model is crucial in simulation and prediciton applications. This paper proposes a two step procedure that generates guarant4eed passive transfer function models from noisy dataw. It consists of an unconstrained optimal noise removal step followed by a passivity enforment of the unconstrained model. The proposed method is aplicable to continuous-time as well as discrete-time systems.
Stability and Cost Optimization in Controlled Random Walks Using Scheduling Fields (2013)

The control of large queueing networks is a notoriously difficult problem. Recently, an interesting new policy design framework for the control problem called h-MaxWeight has been proposed: h-MaxWeight is a natural generalization of the famous MaxWeight policy where instead of the quadratic any other surrogate value function can be applied. Stability of the policy is then achieved through a perturbation technique. However, stability crucially depends on parameter choice which has to be adapted in simulations. In this paper we use a different technique where the required perturbations can be directly implemented in the weight domain, which we call a scheduling field then. Specifically, we derive the theoretical arsenal that guarantees universal stability while still operating close to the underlying cost criterion. Simulation examples suggest that the new approach to policy synthesis can even provide significantly higher gains irrespective of any further assumptions on the network model or parameter choice.
Carbon Dots as a Promising Green Photocatalyst for Free Radical and ATRP‐Based Radical Photopolymerization with Blue LEDs (2019)

Carbon dots (CDs) have been used for the first time as a sensitizer to initiate and activate free radical and controlled radical polymerization, respectively, based on an ATRP protocol with blue LEDs. Consideration of diverse heteroatom-doped CDs indicated that N-doped CDs could serve as an effective photocatalyst and photosensitizer in combination with LEDs emitting either at 405 nm or 470 nm. Free radical polymerization was initiated by combining the CDs with an iodonium or sulfonium salt in tri(propylene glycol) diacrylate. Polymerization of methyl methacrylate (MMA) by photo-induced ATRP was achieved with CDs and ethyl α-bromophenylacetate using Cu<sup>II</sup> as catalyst in the ppm range. The polymers obtained showed temporal control, narrower dispersity ≲1.5, and chain-end fidelity. The first-order kinetics and ON/OFF experiments additionally gave evidence of the constant concentration of polymer radicals. No remarkable cytotoxic activity was observed for the CDs, underlining their biocompatibility.
Polyphenols from Thinned Young Apples: HPLC-HRMS Profile and Evaluation of Their Anti-Oxidant and Anti-Inflammatory Activities by Proteomic Studies (2022)

The qualitative profile of thinned apple polyphenols (TAP) fraction (≈24% of polyphenols) obtained by purification through absorbent resin was fully investigated by LC-HRMS in positive and negative ion mode and using ESI source. A total of 68 polyphenols were identified belonging to six different classes: flavanols, flavonols, dihydrochalchones, flavanones, flavones and organic and phenolic acids. The antioxidant and anti-inflammatory activities were then investigated in cell models with gene reporter for NRF2 and NF-κB and by quantitative proteomic (label-free and SILAC) approaches. TAP dose-dependently activated NRF2 and in the same concentration range (10-250 µg/mL) inhibited NF-κB nuclear translocation induced by TNF-α and IL-1α as pro-inflammatory promoters. Proteomic studies elucidated the molecular pathways evoked by TAP treatment: activation of the NRF2 signaling pathway, which in turn up-regulates protective oxidoreductases and their nucleophilic substrates such as GSH and NADPH, the latter resulting from the up-regulation of the pentose phosphate pathway. The increase in the enzymatic antioxidant cellular activity together with the up-regulation of the heme-oxygenase would explain the anti-inflammatory effect of TAP. The results suggest that thinned apples can be considered as a valuable source of apple polyphenols to be used in health care products to prevent/treat oxidative and inflammatory chronic conditions.
SFIO a striped file I/O library for MPI (2001)

This paper presents the design and evaluation of a Striped File I/O (SFIO) library for parallel I/O within an MPI environment. We present techniques for optimizing communications and disk accesses for small striping factors. Using MPI derived datatype capabilities, we transmit fragmented data over the network by single MPI transfers. We present the I/O performance of the SFIO library on DEC Alpha clusters, both for the Fast Ethernet and for the TNET communication networks.
Investigation of nanodispersion in polystyrene–montmorillonite nanocomposites by solid‐state NMR (2003)

Abstract Nanocomposites result from combinations of materials with vastly different properties in the nanometer scale. These materials exhibit many unique properties such as improved thermal stability, reduced flammability, and improved mechanical properties. Many of the properties associated with polymer–clay nanocomposites are a function of the extent of exfoliation of the individual clay sheets or the quality of the nanodispersion. This work demonstrates that solid‐state NMR can be used to characterize, quantitatively, the nanodispersion of variously modified montmorillonite (MMT) clays in polystyrene (PS) matrices. The direct influence of the paramagnetic Fe 3+ , embedded in the aluminosilicate layers of MMT, on polymer protons within about 1 nm from the clay surfaces creates relaxation sources, which, via spin diffusion, significantly shorten the overall proton longitudinal relaxation time ( T ). Deoxygenated samples were used to avoid the particularly strong contribution to the T of PS from paramagnetic molecular oxygen. We used T as an indicator of the nanodispersion of the clay in PS. This approach correlated reasonably well with X‐ray diffraction and transmission electron microscopy (TEM) data. A model for interpreting the saturation‐recovery data is proposed such that two parameters relating to the dispersion can be extracted. The first parameter, f , is the fraction of the potentially available clay surface that has been transformed into polymer–clay interfaces. The second parameter, ϵ, is a relative measure of the homogeneity of the dispersion of these actual polymer–clay interfaces. Finally, a quick assay of T is reported for samples equilibrated with atmospheric oxygen. Included are these samples as well as 28 PS/MMT nanocomposite samples prepared by extrusion. These measurements are related to the development of high‐throughput characterization techniques. This approach gives qualitative indications about dispersion; however, the more time‐consuming analysis, of a few deoxygenated samples from this latter set, offers significantly greater insight into the clay dispersion. A second, probably superior, rapid‐analysis method, applicable to oxygen‐containing samples, is also demonstrated that should yield a reasonable estimate of the f parameter. Thus, for PS/MMT nanocomposites, one has the choice of a less complete NMR assay of dispersion that is significantly faster than TEM analysis, versus a slower and more complete NMR analysis with sample times comparable to TEM, information rivaling that of TEM, and a substantial advantage that this is a bulk characterization method. © 2003 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 41: 3188–3213, 2003
Effect of imperfections on the hyperuniformity of many-body systems (2018)

A hyperuniform many-body system is characterized by a structure factor $S\left(\mathbit{k}\right)$ that vanishes in the small-wave-number limit or equivalently by a local number variance ${\ensuremath{\sigma}}_{N}^{2}\left(R\right)$ associated with a spherical window of radius $R$ that grows more slowly than ${R}^{d}$ in the large-$R$ limit. Thus, the hyperuniformity implies anomalous suppression of long-wavelength density fluctuations relative to those in typical disordered systems, i.e., ${\ensuremath{\sigma}}_{N}^{2}\left(R\right)\ensuremath{\sim}{R}^{d}$ as $R\ensuremath{\rightarrow}\ensuremath{\infty}$. Hyperuniform systems include perfect crystals, quasicrystals, and special disordered systems. Disordered hyperuniform systems are amorphous states of matter that lie between a liquid and crystal [S. Torquato et al., Phys. Rev. X 5, 021020 (2015)], and have been the subject of many recent investigations due to their novel properties. In the same way that there is no perfect crystal in practice due to the inevitable presence of imperfections, such as vacancies and dislocations, there is no ``perfect'' hyperuniform system, whether it is ordered or not. Thus, it is practically and theoretically important to quantitatively understand the extent to which imperfections introduced in a perfectly hyperuniform system can degrade or destroy its hyperuniformity and corresponding physical properties. This paper begins such a program by deriving explicit formulas for $S\left(\mathbit{k}\right)$ in the small-wave-number regime for three types of imperfections: (1) uncorrelated point defects, including vacancies and interstitials, (2) stochastic particle displacements, and (3) thermal excitations in the classical harmonic regime. We demonstrate that our results are in excellent agreement with numerical simulations. We find that ``uncorrelated'' vacancies or interstitials destroy hyperuniformity in proportion to the defect concentration $p$. We show that ``uncorrelated'' stochastic displacements in perfect lattices can never destroy the hyperuniformity but it can be degraded such that the perturbed lattices fall into class III hyperuniform systems, where ${\ensuremath{\sigma}}_{N}^{2}\left(R\right)\ensuremath{\sim}{R}^{d\ensuremath{-}\ensuremath{\alpha}}$ as $R\ensuremath{\rightarrow}\ensuremath{\infty}$ and $0&lt;\ensuremath{\alpha}&lt;1$. By contrast, we demonstrate that certain ``correlated'' displacements can make systems nonhyperuniform. For a perfect (ground-state) crystal at zero temperature, increase in temperature $T$ introduces such correlated displacements resulting from thermal excitations, and thus the thermalized crystal becomes nonhyperuniform, even at an arbitrarily low temperature. It is noteworthy that imperfections in disordered hyperuniform systems can be unambiguously detected. Our work provides the theoretical underpinnings to systematically study the effect of imperfections on the physical properties of hyperuniform materials.
ChemInform Abstract: Replacement of Phosgene with Carbon Dioxide: Synthesis of Alkyl Carbonates. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
1515: The Effect of Cryopreservation on Human Sperm Hyaluronan Binding Activity (2005)

You have accessJournal of UrologyModerated Poster, Wednesday, May 25, 2005, 8:00 - 10:00 am1 Apr 20051515: The Effect of Cryopreservation on Human Sperm Hyaluronan Binding Activity Matthew C. McCormack, Barry R. Behr, and Stewart W. McCallum Matthew C. McCormackMatthew C. McCormack More articles by this author , Barry R. BehrBarry R. Behr More articles by this author , and Stewart W. McCallumStewart W. McCallum More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)35649-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1515: The Effect of Cryopreservation on Human Sperm Hyaluronan Binding Activity." The Journal of Urology, 173(4S), p. 410 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 410 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Matthew C. McCormack More articles by this author Barry R. Behr More articles by this author Stewart W. McCallum More articles by this author Expand All Advertisement PDF DownloadLoading ...
Cellulose‐click‐ferrocenes as docking spots for cyclodextrin (2012)

Abstract A novel synthesis of ferrocene‐modified cellulose, prepared from 6‐azido‐6‐deoxy‐cellulose and ethynylferrocene, is presented. The two components were coupled via copper‐catalyzed click‐type cycloaddition under microwave‐assisted conditions. The surface structure of the cellulose derivative was investigated in comparison with that of pure, microcrystalline cellulose using electron microscopy (scanning, transmission and scanning transmission), showing iron atoms of ferrocene as homogeneously distributed particles. They are detectable as clear signals in the energy‐dispersive X‐ray profile. In addition, Rame‐β‐cyclodextrin was supramolecularly attached to cellulose and the complex formed was studied by use of 2D ROESY NMR and dynamic light scattering. Copyright © 2012 Society of Chemical Industry
As políticas de inclusão social e informacional das pessoas com deficiência sob a ótica da responsabilidade social (2019)

A informação está associada ao fator de mudança nas estruturas sociais da sociedade, tal constatação levou alguns países a formular diretrizes para minimizar o impacto que trariam para a sociedade, como também acompanhar a inserção na sociedade da informação, sendo necessário estudo acerca do fenômeno informacional. Tais mudanças provocaram o aumento do abismo de inclusão/exclusão informacional que afasta cada vez mais as pessoas com deficiência do acesso contínuo à informação e ao conhecimento e isolando-as da oportunidade de participar de um ambiente de aprendizado que gera um processo de conhecimento, e que os faz sentirem-se incluídos socialmente, e cidadão partícipe da sociedade. O artigo tem como metodologia uma revisão bibliográfica, no qual se propõe a expor a problemática acerca do processo de inclusão/exclusão social das pessoas com deficiência com relação as políticas sociais e de informação sob o olhar da responsabilidade social, destacando elementos como acesso e uso da informação como garantia dos direitos das pessoas com deficiência em serem cidadãos partícipes da sociedade. Como conclusão destacou-se que a sociedade precisa repensar seu olhar para as pessoas com deficiência, considerando a igualdade de direitos para todos, encarando a diversidade como uma forma de aprendizagem contínua, e que esta, deve primar pela qualidade de vida de todos.Palavras-chave: Acesso e uso da informação. Ciência da Informação. Inclusão e exclusão social. Pessoas com deficiência. Sociedade da Informação.Link: http://www.periodicos.ufpb.br/ojs2/index.php/biblio/article/view/40933/20972
An expression system matures: A highly efficient and cost-effective process for phytase production by recombinant strains ofHansenula polymorpha (1999)

An efficient process was developed for the low-cost production of phytases using Hansenula polymorpha. Glucose or glucose syrups, previously reported as repressive substrates, were used as main carbon sources during fermentation. Glucose was even the most productive substrate for high-level production of phytases. Compared with the process using glycerol, the standard carbon source used for this process until now, the use of glucose led to a reduction of more than 80% in the raw materials costs. In addition, exceptionally high concentrations of active enzyme (up to 13.5 g/L) were obtained in the medium, with phytase representing over 97% of the total accumulated protein. These levels greatly exceed those reported so far for any yeast-based expression system. Very efficient downstream processing procedures were developed with product recovery yields over 90%. Both the fermentation and downstream processing were successfully tested in pilot scale up to 2000 L. As a result, H. polymorpha can be used as a highly competitive system for low-cost phytase production. © 1999 John Wiley & Sons, Inc. Biotechnol Bioeng 63: 373–381, 1999.
Effects of Fluoroethylene Carbonate (FEC) on Anode and Cathode Interfaces at Elevated Temperatures (2015)

The use of electrolyte additives is one of the most effective and economical ways to improve battery performance by stabilizing the electrode/electrolyte interface. In this work, we identified that fluoroethylene carbonate (FEC), which is one of the important electrolyte additives, had different impacts on anode and cathode, by investigating a graphite anode and a LiMn2O4 cathode through electrochemical analyses at room and elevated temperatures. In the anode side, the solid electrolyte interphase (SEI) layer derived from FEC exhibited a lower interfacial resistance and excellent thermal stability, showing excellent rate capability and improved cycle retention of cells. In contrast, poor cycling retention and a rapid increase in the interfacial resistance of the cathode were observed at elevated temperature. The poorer performance of the cathode in the FEC-containing cell at elevated temperature was attributed to the formation of a thicker surface layer and to increased Mn dissolution catalyzed by HF, which resulted from FEC dehydrofluorination initiated or accelerated by elevated temperature. Accordingly, it is suggested that the amount of FEC in a full cell must be optimized to minimize the adverse effects of FEC on cathode.
Managing the Desktop Document Dataspace. (2007)

We present a survey of parallel local search algorithms in which we review the concepts that can be used to incorporate parallelism into local search. For this purpose we distinguish between single-walk and multiple-walk parallel local search and between asynchronous and synchronous parallelism. Within the class of single-walk algorithms we differentiate between multiple-step and single-step parallelism. To describe parallel local search we introduce the concepts of hyper neighborhood structures and distributed neighborhood structures. Furthermore, we present templates that capture most of the parallel local search algorithms proposed in the literature. Finally, we discuss some complexity issues related to parallel local search.
Simultaneous Detection of Dopamine, Ascorbic Acid and Uric Acid at Lithographically‐Defined 3D Graphene Electrodes (2013)

Abstract Three dimensional graphene electrodes are presented as highly sensitive electrochemical transducers for the detection of dopamine, ascorbic acid, and uric acid. The detection limits for each separate analyte is approximately 5 µM. In addition the oxidative peak potentials for each are sufficiently separated such that the simultaneous detection of a mixture can be accomplished without any modification steps leading to three well resolved peaks. Increased steady state mass transport profiles due to enhanced diffusion effects at the open porous three dimensional graphene electrodes are also observed.