gebhart/patrepeval huggingface dataset:
Standing on the Shoulders of Giant Frozen Language Models (2022)

Huge pretrained language models (LMs) have demonstrated surprisingly good zero-shot capabilities on a wide variety of tasks. This gives rise to the appealing vision of a single, versatile model with a wide range of functionalities across disparate applications. However, current leading techniques for leveraging a "frozen" LM -- i.e., leaving its weights untouched -- still often underperform fine-tuning approaches which modify these weights in a task-dependent way. Those, in turn, suffer forgetfulness and compromise versatility, suggesting a tradeoff between performance and versatility. The main message of this paper is that current frozen-model techniques such as prompt tuning are only the tip of the iceberg, and more powerful methods for leveraging frozen LMs can do just as well as fine tuning in challenging domains without sacrificing the underlying model's versatility. To demonstrate this, we introduce three novel methods for leveraging frozen models: input-dependent prompt tuning, frozen readers, and recursive LMs, each of which vastly improves on current frozen-model approaches. Indeed, some of our methods even outperform fine-tuning approaches in domains currently dominated by the latter. The computational cost of each method is higher than that of existing frozen model methods, but still negligible relative to a single pass through a huge frozen LM. Each of these methods constitutes a meaningful contribution in its own right, but by presenting these contributions together we aim to convince the reader of a broader message that goes beyond the details of any given method: that frozen models have untapped potential and that fine-tuning is often unnecessary.
Towards a generic receiver chain for particle detectors (2022)

Abstract A software-adaptable receiver tackles some of the highest challenges in particle detector development. While a generic approach never reaches the same performance as a dedicated development, it covers most application fields and can cut down development time and costs. Prototyping and verification of readout methods prior to the building of the complete systems are also facilitated. An in-depth study of existing particle detectors was conducted to define requirements that such a system will have to fulfill. In parallel, a first investigation of configurability is conducted to assess feasibility using an ADC as the central block in the receiver.
Crystal Structure of the Topoisomerase II Poison 9-Amino-[N-(2-dimethylamino)ethyl]acridine-4-carboxamide Bound to the DNA Hexanucleotide d(CGTACG)2 (1999)

The structure of the complex formed between d(CGTACG)(2) and the antitumor agent 9-amino-[N-(2-dimethylamino)ethyl]acridine-4-carboxamide has been solved to a resolution of 1.6 A using X-ray crystallography. The complex crystallized in space group P6(4) with unit cell dimensions a = b = 30.2 A and c = 39.7 A, alpha = beta = 90 degrees, gamma = 120 degrees. The asymmetric unit contains a single strand of DNA, 1. 5 drug molecules, and 29 water molecules. The final structure has an overall R factor of 19.3%. A drug molecule intercalates between each of the CpG dinucleotide steps with its side chain lying in the major groove, and the protonated dimethylamino group partially occupies positions close to ( approximately 3.0 A) the N7 and O6 atoms of guanine G2. A water molecule forms bridging hydrogen bonds between the 4-carboxamide NH and the phosphate group of the same guanine. Sugar rings adopt the C2'-endo conformation except for cytosine C1 which moves to C3'-endo, thereby preventing steric collision between its C2' methylene group and the intercalated acridine ring. The intercalation cavity is opened by rotations of the main chain torsion angles alpha and gamma at guanines G2 and G6. Intercalation perturbs helix winding throughout the hexanucleotide compared to B-DNA, steps 1 and 2 being unwound by 8 degrees and 12 degrees, respectively, whereas the central TpA step is overwound by 17 degrees. An additional drug molecule, lying with the 2-fold axis in the plane of the acridine ring, is located at the end of each DNA helix, linking it to the next duplex to form a continuously stacked structure. The protonated N,N-dimethylamino group of this "end-stacked" drug hydrogen bonds to the N7 atom of guanine G6. In both drug molecules, the 4-carboxamide group is internally hydrogen bonded to the protonated N-10 atom of the acridine ring. The structure of the intercalated complex enables a rationalization of the known structure-activity relationships for inhibition of topoisomerase II activity, cytotoxicity, and DNA-binding kinetics for 9-aminoacridine-4-carboxamides.
Normal patterns of expression of glycosylphosphatidylinositol‐anchored proteins on different subsets of peripheral blood cells: A frame of reference for the diagnosis of paroxysmal nocturnal hemoglobinuria (2006)

For some cell subsets such as the neutrophils additional useful markers could be selected from a relatively broad panel (CD16/CD24/CD55/CD59/CD66b/CD157), whereas for other cell subsets the number of useful antigens was either restricted (monocytes: CD14/CD55/CD157; B cells: CD24/CD48/CD52/CD55; CD4+ T cells: CD48/CD52/CD55; eosinophils: CD55/CD59; CD8+ T cells: CD48/CD55) or limited to a single marker (CD48 on CD56low NK cells, CD55 on BDCA3- dendritic cells and CD56high NK cells, and CD59 for red cells), from all antigens analyzed.
Modeling Copper Planarization Under Mass Transport Controlled Dissolution (2006)

Abstract not Available.
616: AD-PSES-Trail: A Novel Prostate Specific Trail Over-Expressing Adenoviral Vector for Androgen Independent Prostate Cancer Gene Therapy (2004)

You have accessJournal of UrologyDiscussed Poster, Sunday, May 9, 2004, 1:00 - 5:00 pm1 Apr 2004616: AD-PSES-Trail: A Novel Prostate Specific Trail Over-Expressing Adenoviral Vector for Androgen Independent Prostate Cancer Gene Therapy Thomas A. Gardner, Sudhanshu P. Raikwar, Sang-Jin Lee, Paula J. Bunde, Xiong Li, and Chinghai Kao Thomas A. GardnerThomas A. Gardner More articles by this author , Sudhanshu P. RaikwarSudhanshu P. Raikwar More articles by this author , Sang-Jin LeeSang-Jin Lee More articles by this author , Paula J. BundePaula J. Bunde More articles by this author , Xiong LiXiong Li More articles by this author , and Chinghai KaoChinghai Kao More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)37878-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "616: AD-PSES-Trail: A Novel Prostate Specific Trail Over-Expressing Adenoviral Vector for Androgen Independent Prostate Cancer Gene Therapy." The Journal of Urology, 171(4S), p. 164 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 164 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Thomas A. Gardner More articles by this author Sudhanshu P. Raikwar More articles by this author Sang-Jin Lee More articles by this author Paula J. Bunde More articles by this author Xiong Li More articles by this author Chinghai Kao More articles by this author Expand All Advertisement Loading ...
Somatic Epigenetic Silencing of RIPK3 Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma (2020)

These data suggest that RIPK3 acts as a tumor suppressor in malignant mesothelioma by triggering necroptosis and that epigenetic silencing of <i>RIPK3</i> by DNA methylation impairs necroptosis and contributes to chemoresistance and poor survival in this incurable disease.
Thermal conductivity and dynamic mechanical property of glycidyl methacrylate‐grafted multiwalled carbon nanotube/epoxy composites (2011)

Abstract The well dispersed multiwalled carbon nanotube (MWCNT)/epoxy composites were prepared by functionalization of the MWCNT surfaces with glycidyl methacrylate (GMA). The morphology and thermal properties of the epoxy nanocomposites were investigated and compared with the surface characteristics of MWCNTs. GMA‐grafted MWCNTs improved the dispersion and interfacial adhesion in epoxy resin, and enhanced the network structure. The storage modulus of 3 phr GMA‐MWCNTs/epoxy composites at 50°C increased from 0.32 GPa to 2.87 GPa (enhanced by 799%) and the increased tanδ from 50.5°C to 61.7°C (increased by 11.2°C) comparing with neat epoxy resin, respectively. Furthermore, the thermal conductivity of 3 phr GMA‐MWCNTs/epoxy composite is increased by 183%, from 0.2042 W/mK (neat epoxy) to 0.5781 W/mK. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Automatic Construction of Lane-level HD Maps for Urban Scenes (2021)

High definition (HD) maps have demonstrated their essential roles in enabling full autonomy, especially in complex urban scenarios. As a crucial layer of the HD map, lane-level maps are particularly useful: they contain geometrical and topological information for both lanes and intersections. However, large scale construction of HD maps is limited by tedious human labeling and high maintenance costs, especially for urban scenarios with complicated road structures and irregular markings. This paper proposes an approach based on semantic-particle filter to tackle the automatic lane-level mapping problem in urban scenes. The map skeleton is firstly structured as a directed cyclic graph from online mapping database OpenStreetMap. Our proposed method then performs semantic segmentation on 2D front-view images from ego vehicles and explores the lane semantics on a birds-eye-view domain with true topographical projection. Exploiting OpenStreetMap, we further infer lane topology and reference trajectory at intersections with the aforementioned lane semantics. The proposed algorithm has been tested in densely urbanized areas, and the results demonstrate accurate and robust reconstruction of the lane-level HD map.
Enhanced responsiveness of human memory T cells to CD2 and CD3 receptor‐mediated activation (1989)

Previous investigations have defined phenotypic differences between unprimed (naive) and antigen-primed (memory) T cells from human peripheral blood. We now report that memory T cells proliferate much more than naive cells when stimulated with anti-CD3 monoclonal antibody or pairs of anti-CD2 monoclonal antibodies. Enhanced responsiveness to receptor-mediated triggering is a novel mechanism for T cells which could facilitate memory cell response to specific antigen. Furthermore, when triggered via either CD2 or CD3, memory T cells produce substantial amounts of interferon gamma while naive cells produce virtually none; this suggests that differentiation from naive to memory state is accompanied by a stable change in regulation of the gene for interferon-gamma. We conclude that naive and memory T cells are dramatically different in function as well as phenotype.
Building a Sound Company Culture (2000)

For small companies just starting out, the priorities are often generating business and completing the work on time, on budget, and in accordance with applicable standards. In the process of fulfilling these goals, it is easy for owners and managers to overlook the importance of cultivating the kind of atmosphere within the company that owners and employees can be proud of, and to which clients will want to return to. To create the kind of corporate culture desired, principles must be guided by integrity, leadership, dedication, and service. Active, hands-on marketing, clear internal communications, and rewards for imaginative solutions are other key elements to creating the right company philosophy.
Highly Accurate and Precise Measurement Technique for Effective Exposure Dose (2000)

A highly accurate and precise measurement technique for effective exposure dose in optical microlithography has been developed. The effective exposure dose can be obtained by a dose monitor mark in a photomask, called the effective dose meter, which consists of multiple segments including grating patterns with a pitch below the resolution limit and different duty ratios gradually. Since the residual thickness of the photoresist after development changes according to the duty ratio, the effective exposure dose can be obtained by monitoring the film thickness for each segment of effective dose meter. It was found that an extremely high dose resolution of less than 0.01% was achieved in this technique. A dynamic range expansion technique has been also proposed, which has wide measurement range and improved repeatability. Across-wafer variation of the effective exposure dose in the current krypton fluoride excimer laser lithography process was measured as a demonstration of these technologies.
ChemInform Abstract: A General Method for the Synthesis of 3,5‐Diarylcyclopentenones via Friedel—Crafts Acylation of Vinyl Chlorides. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A FUSCA gene of Arabidopsis encodes a novel protein essential for plant development. (1994)

Arabidopsis fusca mutants display striking purple coloration due to anthocyanin accumulation in their cotyledons. We describe six recessive fusca mutants isolated from Agrobacterium-transformed Arabidopsis families. These mutants first become defective during embryogenesis and exhibit limited seedling development. Double mutant constructs revealed that developmental defects were not simply a consequence of anthocyanin accumulation. fusca seedlings showed altered responses to several environmental and endogenous factors. Allelism tests established that three fusca loci are represented by mutants previously described as defective in light-regulated responses. To study the molecular basis of the fusca phenotype, we cloned the FUS6 gene. FUS6 encodes a novel protein that is hydrophilic, alpha-helical, and contains potential protein kinase C phosphorylation sites. The FUSCA proteins appear to act in a network of signal transduction pathways critical for plant development.
A new switch chip for IBM RS/6000 SP systems (1999)

This paper describes the architecture of a third-generation switching element which may appear in future IBM RS/6000 SP interconnection networks. In this paper this ASIC will be referred as the Switch3 switch chip. Like its predecessors, Switch3 is an 8-port device implementing output-queuing using the high-utilization central-buffering technique. However, Switch3 offers significant enhancements over these existing SP switch chips by incorporating advances in both VLSI technology and in recent interconnection network research. Switch3 introduces a new form of adaptive routing with the potential to significantly improve network bandwidth. It also offers support for collective communication via a powerful hardware multicast replication capability. The technology advances allow link bandwidth to be improved to 500 MB/s per direction per link, and allow the central buffer size to be doubled compared to the current SP switch. Furthermore, the larger Switch3 input buffers are capable of supporting link lengths of up to 100 meters, enabling richly-connected, scalable topologies with a high aggregate bandwidth. Finally, Switch3 offers a number of other significant enhancements including limited support for high-priority traffic and detailed performance monitoring information.
Metallboranate und Boranatometallate. VIII. Darstellung und Eigenschaften von dimeren Halogeno‐titan (III)‐ bis (boranaten) [XTi (BH4)2]2 (1973)

Abstract Chloro‐titan(III)‐bis(boranat) ist neben Ti(BH 4 ) 3 Produkt der Reaktion von TiCl 4 ‐Dampf mit festem LiBH 4 ; es entsteht als Hauptprodukt (72%) bei der Umsetzung in Pentan. Analog läßt sich BrTi(BH 4 ) 2 und JTi(BH 4 ) 2 darstellen. Die Verbindungen sind über Halogenbrücken dimerisiert, die im Falle des ClTi(BH 4 ) 2 durch Tetrahydrofuran unter Disproportionieren in Ti(BH 4 ) 3 · nOC 4 H 8 und TiCl 3 · mOC 4 H 8 , nicht aber von Äther aufgebrochen werden. Die IR‐, 11 B‐nmr‐ und Elektronenspektren der Verbindungen werden diskutiert.
Real-time observation of rotational twin formation during molecular-beam epitaxial growth of GaAs on Si (111) by x-ray diffraction (2016)

The formation and evolution of rotational twin (TW) domains introduced by a stacking fault during molecular-beam epitaxial growth of GaAs on Si (111) substrates were studied by in situ x-ray diffraction. To modify the volume ratio of TW to total GaAs domains, GaAs was deposited under high and low group V/group III (V/III) flux ratios. For low V/III, there was less nucleation of TW than normal growth (NG) domains, although the NG and TW growth rates were similar. For high V/III, the NG and TW growth rates varied until a few GaAs monolayers were deposited; the mean TW domain size was smaller for all film thicknesses.
Defensins (1990)

Defensins are a family of small, variably cationic proteins which are highly abundant in the granules of mammalian phagocytes. Three defensins, HNP-1, 2, and 3, comprise 30-50% of total protein in azurophil granules of human neutrophils. Some defensins are broadly antimicrobial, antiviral and cytotoxic, while others are chemotactic, opsonic, or may modulate hormonal responses. The defensin molecule typically consists of 29-34 amino acids with a conserved pattern of disulfide linkage among its 6 cysteines. The three-dimensional fold of defensins forms a highly amphiphilic molecule. Microbicidal and cytotoxic properties of defensins are most likely a consequence of their ability to insert into biological membranes and to generate pores. Defensins are synthesized by phagocytes or their precursors as a 94-95 amino acid charge-neutralized preprodefensin, an arrangement which may avoid cytotoxic injury to the phagocyte. Although defensins were recognized only recently, the existence of homologs in certain invertebrates suggests that they are ancestral components of the host defense system.
Evaluating alternative refrigerants for high ambient temperature environments (2016)

According to the Montreal Protocol, developing countries have started the phase out schedule of the ozone depleting substances, including HCFC refrigerants, in 2015 and expect them to reach 35% reduction in 2020. This commitment to the start the phase out of HCFC refrigerants, especially R-22, in developing countries is seen as an opportunity to introduce lower Global Warming Potential (GWP) refrigerants. Furthermore, this paper summarizes an investigation into the performance of lower GWP refrigerants in high ambient temperature environments, experienced in some of the developed countries, in mini-split air conditioning units.
A new composite coating containing HPMC, beeswax, and Shellac for 'Valencia' oranges and 'Marisol' tangerines (2007)

Commercial coatings used for citrus fruit include carnauba and shellac waxes or resins, which provide an attractive shine to the fruit, but are not necessarily made of 100% food-grade ingredients. A new food-grade formulation based on beeswax (BW), shellac resin (Sh), hydroxypropylmethylcellulose (HPMC), and glycerol (Gly) was tested, along with an experimental polyethylene-candelilla (PE) wax emulsion, and two commercial citrus coatings (shellac and carnauba based). 'Valencia' oranges from a local grove were washed, hand-coated, dried, and stored 2 weeks at 23 to 25 C. The PE and carnauba coatings provided the best weight loss control, and were preferred for appearance by a sensory taste panel. The HPMC-BW-Sh-based coating exhibited the least shine, and was rated similar to the control for appearance. On the contrary, shellac-coated fruit were the shiniest, but had intermediate appearance preference ratings. Shellaccoated fruit had high levels of CO2, followed by HPMC-BW-Sh-coated fruit. Volatiles analysis showed that ethanol, methanol, ethyl actetae, and hexanal were high in shellac-coated fruit, while uncoated oranges had higher levels of volatile compounds that characterize fresh citrus flavor. The HPMC-containing coating was modified to increase permeability to O2 and CO2 and four formulations were tested on 'Marisol' tangerines from Spain, and stored at 23 C for 1, 2, and 3 weeks. A reduction of the HPMC : glycerol ratio from 18% : 11% to 11% : 18% improved gas permeability and sensory quality of tangerine stored 1 and 2 weeks at 24 C. Increasing solid content (SC) in the composite coating from 5% to 8% reduced weight loss. Therefore, the HPMC : BW:Sh-containing formulation with HPMC : glycerol ratio of 11% : 18% and at 8% SC could be considered an edible coating appropriate for tangerines.
Capacitive Feedthroughs for Medical Implants (2016)

Important technological advances in the last decades paved the road to a great success story for electrically stimulating medical implants, including cochlear implants or implants for deep brain stimulation. However, there are still many challenges in reducing side effects and improving functionality and comfort for the patient. Two of the main challenges are the wish for smaller implants on one hand, and the demand for more stimulation channels on the other hand. But these two aims lead to a conflict of interests. This paper presents a novel design for an electrical feedthrough, the so called capacitive feedthrough, which allows both reducing the size, and increasing the number of included channels. Capacitive feedthroughs combine the functionality of a coupling capacitor and an electrical feedthrough within one and the same structure. The paper also discusses the progress and the challenges of the first produced demonstrators. The concept bears a high potential in improving current feedthrough technology, and could be applied on all kinds of electrical medical implants, even if its implementation might be challenging.
‘ZAIDE’ IN THE DEVELOPMENT OF MOZART'S OPERATIC LANGUAGE (1991)

Journal Article ‘ZAIDE’ IN THE DEVELOPMENT OF MOZART'S OPERATIC LANGUAGE Get access LINDA L. TYLER LINDA L. TYLER Search for other works by this author on: Oxford Academic Google Scholar Music and Letters, Volume 72, Issue 2, May 1991, Pages 214–235, https://doi.org/10.1093/ml/72.2.214 Published: 01 May 1991
The neutrophil-activating protein (HP-NAP) ofHelicobacter pyloriis a potent stimulant of mast cells (2002)

Infection by Helicobacter pylori causes an acute inflammatory response followed by a chronic infection of the human gastric mucosa. A neutrophil-activating protein (HP-NAP) has been identified in H.pylori, and its role in infection and immune response is currently under investigation. Here, we show that HP-NAP induces beta-hexosaminidase release and interleukin-6 production in peritoneal mast cells, two actions which are completely inhibited by pertussis toxin. We also show that in polarized epithelial cell monolayers HP-NAP translocates from the apical to the basolateral domain, where mast cells are located. These findings characterize HP-NAP as an inflammatory factor of H.pylori that is effective from the beginning of the inflammatory cascade.
Are Solvent and Dispersion Effects Crucial in Olefin Polymerization DFT Calculations? Some Insights from Propylene Coordination and Insertion Reactions with Group 3 and 4 Metallocenes (2014)

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