gebhart/patrepeval huggingface dataset:
Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia (2016)

ABSTRACT Schizophrenia (SCZ), bipolar disorder (BD) and recurrent major depressive disorder (rMDD) are common psychiatric illnesses. All have been associated with lower cognitive ability, and show evidence of genetic overlap and substantial evidence of pleiotropy with cognitive function and neuroticism. Disrupted in schizophrenia 1 (DISC1) protein directly interacts with a large set of proteins (DISC1 Interactome) that are involved in brain development and signaling. Modulation of DISC1 expression alters the expression of a circumscribed set of genes (DISC1 Regulome) that are also implicated in brain biology and disorder. Here, we report targeted sequencing of 59 DISC1 Interactome genes and 154 Regulome genes in 654 psychiatric patients and 889 cognitively-phenotyped control subjects, on whom we previously reported evidence for trait association from complete sequencing of the DISC1 locus. Burden analyses of rare and singleton variants predicted to be damaging were performed for psychiatric disorders, cognitive variables and personality traits. The DISC1 Interactome and Regulome showed differential association across the phenotypes tested. After family-wise error correction across all traits (FWER across ), an increased burden of singleton disruptive variants in the Regulome was associated with SCZ (FWER across P =0.0339). The burden of singleton disruptive variants in the DISC1 Interactome was associated with low cognitive ability at age 11 (FWER across P =0.0043). These results suggest that variants in the DISC1 Interactome effect the risk of psychiatric illness through altered expression of schizophrenia-associated genes. The biological impact of rare variants highlighted here merit further study.
Mouse Palmitoyl Protein Thioesterase: Gene Structure and Expression of cDNA (1998)

Palmitoyl protein thioesterase (PPT) is the defective enzyme in infantile neuronal ceroid lipofuscinosis (INCL), which is a recessively inherited, progressive neurodegenerative disorder. We present here the cloning, chromosomal mapping, genomic structure, and the expression of the cDNA of mouse PPT. The mouse PPT gene spans >21 kb of genomic DNA and contains nine exons with a coding sequence of 918 bp. Fluorescence in situ hybridization to metaphase chromosomes localized the mouse PPT gene to the chromosome 4 conserved syntenic region with human chromosome 1p32 where the human PPT is located. PPT is expressed widely in a variety of mouse tissues. The mouse PPT cDNA is conserved highly with the human and rat PPT both at the nucleotide and amino acid sequence level. Transient expression of mouse PPT in COS-1 cells yielded a 38/36-kD differentially glycosylated polypeptide that was also secreted into culture media. Immunofluorescence analysis of transiently transfected HeLa cells indicated lysosomal localization of mouse PPT. Based on the high conservation of the gene and polypeptide structure as well as similar processing and intracellular localization, the function of PPT in mouse and human are likely to be very similar.
Inclusion of inter-temporal constraints into a distributed Newton-Raphson method (2012)

Newton-Raphson based methods are widely used for solving Optimal Power Flow (OPF) problems. Convergence can be sensitive to the starting point of the algorithm, the step size, and the condition number of the Jacobian. The inclusion of inter-temporal constraints, i.e., constraints that link successive time steps in the optimization, can in certain cases cause the Jacobian to become singular and Newton-Raphson to diverge. These cases occur when the binding inter-temporal constraints do not fulfill the Linear Independence Constraint Qualification (LICQ). In this paper, we discuss the conditions under which this happens, and analyze when singularities occur in a particular storage device model test case.
Terahertz spectroscopy and imaging for the detection and identification of Illicit drugs (2017)

Recently, Terahertz technologies, due to the extensive research and tremendous progress achieved in the field of Terahertz radiation, promise countless potential applications in the fields of security and defense. A particular interest is the development of new technologies that enable the identification of concealed prohibited drugs. This paper surveys the existing research which investigates the utilization of Terahertz spectroscopy and imaging in the detection and identification of illicit drugs. It sheds light on the terahertz time domain spectroscopy which is used to obtain the Terahertz fingerprint spectra of drugs-of-abuse. It also focuses on various Terahertz imaging techniques that are used to probe the presence of illegal drugs by penetrating packaging and concealment materials. Furthermore, this paper addresses current challenges and future research areas for the security application of Terahertz technologies.
Strain measurement by oscillator circuit sensor using dummy gauge (2015)

The strain measurement system using a CMOS inverter oscillator circuit is simple and can be omit an amplifier because a counting device measures frequency changes of circuit voltage output caused by resistance changes of a strain gauge. Moreover, the miniaturization and the creation of a wireless system become possible easily, and this system is an effective method which can be applied to large-scale strain measurement and strain measurement on rotating elements. However, this measuring method may be subject to the influences of temperature properties of elements used in the circuit and an external noise, because the resistance change of a strain gauge is measured directly by the oscillator circuit. In this study, static tensile tests were carried out and the tensile strains were measured by using this measuring method. Through the test results, it has been shown that, by using a dummy gauge in addition to a strain gauge for measurement and taking the difference of both output results, the influences have been deleted and the measurement accuracy has been improved.
W 2 F 2 Q (2000)

Recently, there is a growing interest in wireless packet communications due to the explosive growth in wireless communications and the Internet. In this stage, quality of service (QoS) provisioning in wireless/mobile packet networks is becoming more and more important. A key factor in QoS provisioning is packet-scheduling. However, conventional scheduling algorithms in wired network cannot be directly applicable to wireless communication environments because of wireless-specific characteristics : bursty and location-dependent errors.
Association between Coronary Artery Spasm and the risk of incident Diabetes: A Nationwide population-based Cohort Study (2021)

<b>Background:</b> Non-diabetic coronary artery spasm (CAS) without obstructive coronary artery disease increases insulin resistance. We investigated the risk of incident type 2 diabetes (diabetes) associated with CAS. <b>Methods:</b> Patient records were retrospectively collected from the Taiwan National Health Insurance Research Database during the period 2000-2012. The matched cohorts consisted of 12,413 patients with CAS and 94,721 patients in the control group. <b>Results:</b> During the entire follow-up, the incidence of newly-diagnosed diabetes was 22.2 events per 1000 person-years in the CAS group and 13.9 events per 1000 person-years in the control group. The increased risk of CAS-related incident diabetes was observed regardless of sex and length of follow-up. The median time to incident diabetes was 2.9 and 3.5 years in the CAS and the control group (<i>P</i> <0.001), respectively, regardless of sex. Although age did not affect the risk of CAS-related incident diabetes, the risk was less apparent in the subgroups of male, dyslipidemia, chronic obstructive pulmonary disease, stroke, gout and medicated hypertension. However, CAS patients aged <50 years compared with patients ≥50 years had a greater risk of incident diabetes in females but not in males. Older CAS patients developed diabetes in a shorter length of time than younger patients. <b>Conclusion:</b> CAS is a risk factor for incident diabetes regardless of sex. However, females aged <50 years have a more apparent risk for CAS-related diabetes than old females, which is not observed in males. The median time of 2.9 years to incident diabetes warrants close follow-up.
Genetic Subtype-Independent Inhibition of Human Immunodeficiency Virus Type 1 Replication by CC and CXC Chemokines (1998)

We have studied the breadth and potency of the inhibitory actions of the CC chemokines macrophage inhibitory protein 1alpha (MIP-1alpha), MIP-1beta, and RANTES against macrophage-tropic (M-tropic) primary isolates of human immunodeficiency virus type 1 (HIV-1) and of the CXC chemokine stromal cell-derived factor 1alpha against T-cell-tropic (T-tropic) isolates, using mitogen-stimulated primary CD4+ T cells as targets. There was considerable interisolate variation in the sensitivity of HIV-1 to chemokine inhibition, which was especially pronounced for the CC chemokines and M-tropic strains. However, this variation was not obviously dependent on the genetic subtype (A through F) of the virus isolates. Peripheral blood mononuclear cell donor-dependent variation in chemokine inhibition potency was also observed. Among the CC chemokines, the rank order for potency (from most to least potent) was RANTES, MIP-1beta, MIP-1alpha. Some M-tropic isolates, unexpectedly, were much more sensitive to RANTES than to MIP-1beta, whereas other isolates showed sensitivities comparable to those of these two chemokines. Down-regulation of the CCR5 and CXCR4 receptors occurred in cells treated with the cognate chemokines and probably contributes to anti-HIV-1 activity. Thus, for CCR5, the rank order for down-regulation was also RANTES, MIP-1beta, MIP-1alpha.
Urolithiasis, Endourology and Laparoscopy (2006)

No AccessJournal of UrologyAdult urology1 Aug 2006Urolithiasis, Endourology and Laparoscopy Ralph ClaymanM.D. Ralph ClaymanRalph Clayman View All Author Informationhttps://doi.org/10.1016/j.juro.2006.05.015AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Urolithiasis, Endourology and Laparoscopy." The Journal of Urology, 176(2), pp. 604–605 References 1 : Effects of oral pyridoxine upon plasma and 24-hour urinary oxalate levels in normal subjects and stone formers with idiopathic hypercalciuria. Urol Res1990; 18: 393. Crossref, Medline, Google Scholar © 2006 by American Urological AssociationFiguresReferencesRelatedDetails Volume 176Issue 2August 2006Page: 604-605 Advertisement Copyright & Permissions© 2006 by American Urological AssociationMetrics Author Information Ralph Clayman More articles by this author Expand All Advertisement PDF downloadLoading ...
Helicopter Mountain Rescue in Slovenia from 2011 to 2015 (2018)

A significant number of mountain rescue operations were conducted in Slovenia from 2011 through 2015. Most of these were needed for injured, ill, or deceased persons. A notable number of rescues in 2015 required a helicopter.
Microstructure and properties of Bi-Sr-Ca-Cu-O with additions of nanometer-scale alumina (1999)

Al/sub 2/O/sub 3/ particles /spl ap/30 nm in size were added to Bi/sub 2/Sr/sub 2/CaCu/sub 2/O/sub x/ in a 1:4 molar ratio. For comparison, 0.3- and /spl ap/3-/spl mu/m Al/sub 2/O/sub 3/ particles were added to separate batches. All of the materials were partial-melt processed. The Al/sub 2/O/sub 3/ reacted during melting to form stable compounds, primarily of approximate composition (Sr,Ca)/sub 2/AlO/sub 4/. All additions caused slight decreases in the T/sub c/ and melting point of the Bi/sub 2/Sr/sub 2/CaCu/sub 2/O/sub x/. The submicrometer Al/sub 2/O/sub 3/ additions induced large expansions in magnetic-hysteresis width at 6 K. Electron microscopy examination strongly suggested that the hysteresis expansion was related to alloying of the Bi/sub 2/Sr/sub 2/CaCu/sub 2/O/sub x/ matrix rather than to pinning by volume defects.
Benzo[d][1,2,3]thiadiazole (isoBT): Synthesis, Structural Analysis, and Implementation in Semiconducting Polymers (2016)

Benzo[d][2,1,3]thiadiazole (BT) is a markedly electron-deficient heterocycle widely employed in the realization of organic semiconductors for applications spanning transistors, solar cells, photodetectors, and thermoelectrics. In this contribution, we implement the corresponding isomer, benzo[d][1,2,3]thiadiazole (isoBT), along with new 6-fluoro-isoBT and 5,6-difluoro-isoBT units as synthons for constructing alternating copolymers with tetrathiophene (P1–P3). New isoBT-based small molecules as well as the corresponding BT-quaterthiophene based polymers (P4–P6) are synthesized and characterized to probe architectural, electronic structural, and device performance differences between the two families. The results demonstrate that isoBT complements BT in enabling high-performance optoelectronic semiconductors with P3 exhibiting hole mobilities surpassing 0.7 cm2/(V s) in field-effect transistors and power conversion efficiencies of 9% in bulk-heterojunction solar cells.
Measurement of Differential Radar Cross Section of UHF RFID Tags (2009)

International audience
Noise-Vibration-Harshness-Modeling and Analysis of a Permanent-Magnetic Disc Rotor Axial-Flux Electric Motor (2017)

A drive-system-based modeling approach for electromagnetically excited noise-vibration-harshness (NVH) simulation of a disc rotor permanent-magnetic axial-flux synchronous motor is introduced. The electric motor type requires a 3-D finite-element (FE)-based modeling for electrodynamics and magnetomechanical coupling. The methodic focus relies on orthogonal 3-D Fourier-representations for structural modal displacements and for magnetic force densities. The application of Galerkin-projection based on a supermesh construction between source FE meshes to equidistant 3-D grids is hereby required. A significant data reduction for model parametrization is achieved and a low-rank domain coupling matrix, including a high technical interpretability, is derived. Thus efficient NVH simulations of operation cycles including inverter and control influences can be performed within an order-reduced formulation. This paper is the first to derive a fully 3-D FE-based NVH analysis workflow for electric machines under realistic operating conditions for a routine industrial applicability. The high validity of the methodology is proven by a good agreement to real world measurements.
Efficient Conditions for the Palladium(II) Mediated Coupling of Organostannanes: The Synthesis of 1,3-Dienes, 1,4-Dienes, 1,3-Diynes and Biphenyls (1997)

Convenient conditions are described for the preparation of 1,3-dienes by vinylstannane homocoupling using palladium(II)-catalysis with oxygen (or air) for Pd(0)/Pd(II) reoxidation; related homo-couplings, and cross-coupling reactions with allylstannane, are used to obtain 1,3-diynes, biaryls and 1,4-dienes.
Error in Self-Stabilizing Spanning-Tree Estimation of Collective State (2017)

Estimating collective state is an important component of many distributed systems, but has inherent challenges in balancing the availability of estimates against their accuracy. In this paper, we analyze the error bounds and dynamics of a commonly used family of self-stabilizing state estimation algorithms based on spanning trees. We find that in the worst case transients can duplicate values leading to exponential overestimates or can drop values leading to near total loss of information. The same analysis, however, also suggests that these problems can be mitigated by prioritizing smoothness in the adaptation of distance estimates used to maintain the spanning tree, and this mitigating effect is supported by results in simulation.
O -2-Alkylated Cytosine Acyclic Nucleoside Phosphonamidate Prodrugs Display Pan-Genotype Antiviral Activity against African Swine Fever Virus (2022)

African swine fever virus (ASFV) causes a highly contagious hemorrhagic disease with case fatality rates approaching 100% in domestic pigs. ASFV is responsible for substantial economic losses, but despite ongoing efforts, no vaccine or antiviral agent is currently available. Attempts to control the spread of ASFV are dependent on early detection, adherence to biosecurity measures, and culling of infected herds. However, an effective antiviral agent may be used in lieu of or in conjunction with a vaccine to effectively curb ASFV outbreaks. The dose-dependent antiviral activities of two amidate prodrugs (compounds 1a and 1b) of <i>O</i>-2-alkylated 3-fluoro-2-(phosphonomethoxy)propyl cytosine [(<i>R</i>)-<i>O</i>-2-alkylated FPMPC] against ASFV isolates of four different genotypes were determined. Both compounds were found to inhibit ASFV progeny virus output by >90% at noncytotoxic concentrations (<25 μM) in primary porcine macrophages. Analysis of viral transcription and viral protein synthesis indicated that these acyclic nucleotide analogues inhibited late gene expression. Interestingly, time-of-addition studies suggest different viral targets of the compounds, which may be attributed to their differing amino acid prodrug moieties. In view of their promising antiviral activity, these nucleotide analogues merit further evaluation as potential prophylactic and/or therapeutic agents against ASFV infection and their antiviral efficacy <i>in vivo</i> should be considered. <b>IMPORTANCE</b> African swine fever virus is a highly contagious hemorrhagic viral disease. Since its transcontinental spread to Georgia in 2007, ASFV has continued to spread across the globe into countries previously without infection. It is responsible for substantial losses in the domestic pig population and presents a significant threat to the global swine industry. Despite ongoing efforts, there are no vaccines currently available; in their absence, antiviral agents may be a viable alternative. The significance of our research is in identifying the pan-genotype antiviral activity of prodrugs of <i>O</i>-2-alkylated 3-fluoro-2-(phosphonomethoxy)propyl cytosine, which will drive further research on the development of these compounds as antivirals against ASFV.
Development of Image Recognition Processor Based on Configurable Processor (2005)

We developed an image recognition processor, “Visconti,” based on a configurable processor. Three VLIW processors that execute three instructions in parallel are integrated into a single chip with peripheral modules such as video I/Os and an SDRAM controller. Each VLIW processor has a RISC processor core and a VLIW coprocessor dedicated to image processing. The coprocessor executes SIMD instructions such as 8-parallel byte. Visconti was fabricated using 0.13μm CMOS technology, operates at 150MHz, and consumes about 1W. We present actual application examples of Visconti, onboard surveillance for automobiles and face recognition. Compared to cases in which only the processor core is used, execution speed per one processor increases about 16 times for onboard surveillance and about five times per three processors for face recognition. These applications can be processed in real time.
Development of 3D Hepatic Constructs Within Polysaccharide-Based Scaffolds with Tunable Properties (2020)

Organoids production is a key tool for in vitro studies of physiopathological conditions, drug-induced toxicity assays, and for a potential use in regenerative medicine. Hence, it prompted studies on hepatic organoids and liver regeneration. Numerous attempts to produce hepatic constructs had often limited success due to a lack of viability or functionality. Moreover, most products could not be translated for clinical studies. The aim of this study was to develop functional and viable hepatic constructs using a 3D porous scaffold with an adjustable structure, devoid of any animal component, that could also be used as an in vivo implantable system. We used a combination of pharmaceutical grade pullulan and dextran with different porogen formulations to form crosslinked scaffolds with macroporosity ranging from 30 µm to several hundreds of microns. Polysaccharide scaffolds were easy to prepare and to handle, and allowed confocal observations thanks to their transparency. A simple seeding method allowed a rapid impregnation of the scaffolds with HepG2 cells and a homogeneous cell distribution within the scaffolds. Cells were viable over seven days and form spheroids of various geometries and sizes. Cells in 3D express hepatic markers albumin, HNF4α and CYP3A4, start to polarize and were sensitive to acetaminophen in a concentration-dependant manner. Therefore, this study depicts a proof of concept for organoid production in 3D scaffolds that could be prepared under GMP conditions for reliable drug-induced toxicity studies and for liver tissue engineering.
Velocity Obstacle Based Risk-Bounded Motion Planning for Stochastic Multi-Agent Systems (2022)

In this paper, we present an innovative risk-bounded motion planning methodology for stochastic multi-agent systems. For this methodology, the disturbance, noise, and model uncertainty are considered; and a velocity obstacle method is utilized to formulate the collision-avoidance constraints in the velocity space. With the exploitation of geometric information of static obstacles and velocity obstacles, a distributed optimization problem with probabilistic chance constraints is formulated for the stochastic multi-agent system. Consequently, collision-free trajectories are generated under a prescribed collision risk bound. Due to the existence of probabilistic and disjunctive constraints, the distributed chance-constrained optimization problem is reformulated as a mixed-integer program by introducing the binary variable to improve computational efficiency. This approach thus renders it possible to execute the motion planning task in the velocity space instead of the position space, which leads to smoother collision-free trajectories for multi-agent systems and higher computational efficiency. Moreover, the risk of potential collisions is bounded with this robust motion planning methodology. To validate the effectiveness of the methodology, different scenarios for multiple agents are investigated, and the simulation results clearly show that the proposed approach can generate high-quality trajectories under a predefined collision risk bound and avoid potential collisions effectively in the velocity space.
Development of a Structural Health Monitoring System for Guangzhou New TV Tower (2008)

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