gebhart/patrepeval huggingface dataset:
3D reactive inkjet printing of bisphenol A-polycarbonate (2022)

Additive Manufacturing (AM) techniques have gained extensive attention recently as they are able to directly produce 3D parts utilising a layer-by-layer manner. Inkjet printing is one such technique which can produce micron-scale features but is generally constrained to liquid viscosities of less than 30 mPa·s, therefore available materials are limited. A 3D reactive inkjet printing (3DRIJP) approach to deposit low viscosity monomers and polymerise in-situ to form polymer parts is emerging. In this work, a 3DRIJP approach has been developed to fabricate bisphenol A-polycarbonate (BPA-PC) for the first time by using a low viscosity reactive ink containing monomers, catalyst and solvent. A set of processing parameters were explored and optimised including temperature of droplet formation, substrate temperature and droplet spacing to print films. With a thermal post-curing process, BPA-PC was formed successfully with a molecular weight comparable to those which were manufactured by the conventional melt transesterification process. The thermal properties were evaluated suggesting good thermal resistance characteristics. Finally, a 3D ziggurat structure was printed to demonstrate the capability to fabricate BPA-PC by an AM method, thus broadened the library of AM materials to include engineering grade polymers via 3DRJIP. This approach was innovative in both the BPA-PC material formulation and the 3DRIJP process development from traditional inkjet printing methods, where a single printable formulation of monomers for thermoplastic optical-clear BPA-PC was able to be printed using one printhead to form 3D structures.
New Methods To Assess Susceptibilities of Aspergillus Isolates to Caspofungin (2003)

Echinocandins are a group of antifungal agents that target 1,3-beta-glucan synthase, causing disruption of mold growth at cells compromising tips and branch points. In part because echinocandins do not induce clear growth inhibition end points using broth dilution techniques, methods to test susceptibility have not yet been standardized. We developed a novel susceptibility assay that measures growth of Aspergillus species on solid agar media that contain serial dilutions of caspofungin (agar dilution). Results of agar dilution testing of multiple isolates were compared to results obtained by broth microdilution (MIC), microscopic evaluation (minimal effective concentration [MEC]), and a new method to measure fungal burden, quantification of secreted hyphal antigen. MICs obtained by the agar dilution method were within 1 dilution of MECs for 85% of the Aspergillus isolates; the highest agreement was observed for isolates of Aspergillus niger (95%), which were particularly susceptible to caspofungin. Agar dilution MICs were also consistent with those obtained by quantifying antigen secretion. MICs obtained by broth microdilution were different than MICs by any other method. Several Aspergillus isolates with decreased susceptibility to caspofungin were identified. Agar dilution is simple and reproducible, and results were consistent with the results of more technically demanding techniques. This method may be appropriate for use in the clinical laboratory.
Instantaneous phase-shifted speckle interferometer for measurement of large optical structures (2004)

Digital Speckle Pattern Interferometry (DSPI) is a well-established method for the measurement of diffuse objects in experimental mechanics. DSPIs are phase shifting interferometers. Three or four bucket temporal phase shifting algorithms are commonly used to provide phase shifting. These algorithms are sensitive to vibrations and can not be used to measure large optical structures far away from the interferometer. In this research a simultaneous phase shifted interferometer, PhaseCam product of 4D Technology Corporation in Tucson Arizona, is modified to be a Simultaneous phase shifted Digital Speckle Pattern Interferometer (SDSPI). Repeatability, dynamic range, and accuracy of the SDSPI are characterized by measuring a 5 cm x 5 cm carbon fiber coupon.
Information, Quantum Mechanics, and the Universe (2018)

The Universe is the largest known quantum computer, calculating its own evolution in real time according to the laws of quantum mechanics. Here on earth, scientists and engineers have been trying to “tame” quantum mechanics for the purpose of computation. A sufficiently powerful quantum computer could defeat all known methods of secure communication over the internet. Quantum computation can also deliver radical speedup of important problems like database searching, optimization problems and materials design. In this talk, I will try to point out the deep connections between information, quantum mechanics and the Universe, and convey the excitement of researchers who are working to instigate a second quantum revolution.
ChemInform Abstract: ANGIOTENSIN CONVERTING ENZYME INHIBITORS: 1‐GLUTARYLINDOLINE‐2‐CARBOXYLIC ACID DERIVATIVES (1984)

Abstract Wie im Formelschema skizziert, werden die Indoline (VII) dargestellt.
A quantitative HPLC method for the quality assurance of Echinacea Products on the North American market (2000)

A rapid and quantitative method of quality assurance for marker phytochemicals in products containing material derived from Echinacea species has been developed. In order to assess the efficiency of extraction of phytochemicals from the roots and aerial parts of Echinacea purpurea and E. angustifolia, a study of solvent mixtures and extraction methods was carried out to determine the recovery of known compounds from plant materials. Ultrasonic extraction of dried samples with methanol:water (7:3) or ethanol:water (7:3) gave good yields of cichoric acid, echinacoside and the alkamides, undeca-2E,4Z-diene-8,10-diynoic acid isobutylamide and a mixture of dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides (recoveries of 89%, 85%, 80% and 90%, respectively). The HPLC separation of the phenolic compounds cichoric acid, chlorogenic acid and echinacoside was also improved by careful attention to the pH of the mobile phase. A shortened HPLC column allowed turnaround times of 22 min for phenolic components and 15 min for alkamides with lower solvent use. Assessment of commercial raw materials from the North American market using the new method was useful for confirmation of species and showed a very large variation in concentration of markers in the products sold in this market. Copyright © 2000 John Wiley & Sons, Ltd.
Selectively Impaired CD8+ but Not CD4+ T Cell Cycle Arrest during Priming as a Consequence of Dendritic Cell Interaction with Plasmodium -Infected Red Cells (2005)

Individuals living in malaria-endemic areas show generally low T cell responses to malaria Ags. In this study, we show murine dendritic cell (DC) interaction with parasitized erythrocytes (pRBC) arrested their maturation, resulting in impaired ability to stimulate naive, but not recall T cell responses in vitro and in vivo. Moreover, within the naive T cell population, pRBC-treated DC were selectively deficient in priming CD8(+) but not CD4(+) T cells. Indeed, DC that had taken up pRBC were shown for the first time to efficiently prime CD4(+) T cell responses to a known protective merozoite Ag, MSP4/5. In contrast, impaired priming resulted in decreases in both proliferation and cytokine production by CD8(+) T cells. Deficient priming was observed to both a model and a Plasmodium berghei-specific CD8(+) T cell epitope. The mechanisms underlying the inability of parasite-treated DC to prime CD8(+) T cells were explored. pRBC treatment of DC from wild-type C57BL/6, but not from IL-10 knockout animals, suppressed DC-mediated T cell priming across a Transwell, suggesting active IL-10-dependent suppression. CD8(+) T cells were arrested at the G(0) stage of the cell cycle after two cell divisions post-Ag stimulation. The proliferation arrest was partially reversible by the addition of IL-2 or IL-7 to responder cultures. These results suggest that in malaria-endemic areas, priming of CD8(+) T cell responses may be more difficult to induce via vaccination than the priming of CD4(+) T cells. Moreover, pathogens may selectively target the CD8(+) T cell arm of protective immunity for immune evasion.
Definition of a national program in energy-efficient pump utilization. Volume II. Contract management. Second bi-monthly progress report, July 10-September 10, 1976 (1976)

Progress is reported in a study of energy requirements for pumping operations in the USA. The purpose of this work is to identify areas where optimized or improved pump design and operation could result in energy conservation in industrial plants, pipeline transport, power plants, municipal facilities such as sewage and water works, and other pump locations. (LCL)
Use Of Autocorrelation To Improve The Three Dimensional Plot Of Transcutaneous Human electrogastrograms (2005)

Transcutaneous human electrogastrograms (EGG) have been recorded for many years without significant improvement in their interpretation. The application of amplitude or power spectrum analysis is a powerful method to analyse EGG signals which have a relatively narrow frequency band and infralow fundamental frequencies (0.03-0.1 Hz) . Three dimensional plots are often used to represent the dynamics of the amplitude or power changes in the EGG signals vs. frequency and time. Because of the movement and respiratory artifacts three dimensional plots are not always clear enough to allow further interpretation of the results. In this paper we address that problem suggesting three dimensional plot of the autocorrelated EGG signals. The proposed method minimizes the influence of the artifacts and provides both repeatable results and good possibilities for interpretation.
Lung Volume Reduction Coil Treatment vs Usual Care in Patients With Severe Emphysema (2016)

clinicaltrials.gov Identifier: NCT01822795.
Importance of Practical Relevance and Design Modules in Electrical Circuits Education (2011)

The interactive technical electronic book, TechEBook, currently under development at the University of Central Florida (UCF), provides a useful tool for engineers and scientists through unique features compared to the most used traditional electrical circuit textbooks available in the market. TechEBook has comprised the two worlds of classical circuit books and an interactive operating platform such as iPads, laptops and desktops utilizing Java Virtual Machine operator. The TechEBook provides an interactive applets screen that holds many modules, in which each had a specific application in the self learning process.&#x0D; &#x0D; This paper describes two of the interactive techniques in the TechEBook known as, Practical Relevance Modules (PRM) and Design Modules (DM). The Practical Relevance Module will assist the readers to learn electrical circuit analysis and to understand the practical application of the electrical network theory through solving real world examples and problems. The Design Module will help students design real-life problems. These modules will be displayed after each section in the TechEBook for the user to relate his/her understanding with the outside world, which introduces the term me-applying and me-designing, as a comprehensive full experience for self or individualized education. The main emphasis of this paper is the PRM while the DM will be discussed in brief. A practical example of applying the PRM and DM features is discussed as part of a basic electrical engineering course currently given at UCF and results show improved student performances in learning materials in Electrical Circuits. In the future, such modules can be redesigned to become highly interactive with illustrated animations.
Search for neutral MSSM Higgs bosons decaying to a pair of tau leptons in pp collisions (2014)

A search for neutral Higgs bosons in the minimal supersymmetric extension of the standard model (MSSM) decaying to tau-lepton pairs in pp collisions is performed, using events recorded by the CMS experiment at the LHC. The dataset corresponds to an integrated luminosity of 24.6 fb -1 , with 4.9 fb -1 at 7 TeV and 19.7 fb -1 at 8 TeV. To enhance the sensitivity to neutral MSSM Higgs bosons, the search includes the case where the Higgs boson is produced in association with a b-quark jet. No excess is observed in the tau-lepton-pair invariant mass spectrum. Exclusion limits are presented in the MSSM parameter space for different benchmark scenarios, m max h , m mod+ h , m mod- h , light-stop, lightstau, -phobic, and low-m H . Upper limits on the cross section times branching fraction for gluon fusion and b-quark associated Higgs boson production are also given.
Standing Mesochannels: Mesoporous PdCu Films with Vertically Aligned Mesochannels from Nonionic Micellar Solutions (2018)

Mesoporous bimetallic palladium (Pd) alloy films with mesochannels perpendicularly aligned to the substrate are expected to show superior electrocatalytic activity and stability. The perpendicular mesochannels allow small molecules to efficiently access the active sites located not only at the surface but also within the film because of low diffusion resistance. When compared to pure Pd films, alloying with a secondary metal such as copper (Cu) is cost-effective and promotes resistance against adventitious poisoning through intermediate reactions known to impair the electrocatalytic performance. Here, we report the synthesis of mesoporous PdCu films by electrochemical deposition in nonionic micellar solutions. The mesoporous structures are vertically aligned on the substrate, and the final content of Pd and Cu can be adjusted by tuning the initial precursor molar ratio in the electrolyte solution.
Uniform single-sided induction heating using multiphase, multi-resonant halbach windings (2014)

Traditional induction heating cooktops typically employ a circular planar coil in resonance excited by a switching inverter. This configuration results in stray magnetic fields below the coil and non-uniform heating profile on the top. This paper presents the concept of multiphase, multi-resonant induction heating using a Halbach winding arrangement to eliminate the shortcomings of the traditional cooktop. A multiphase winding structure enables a traveling magnetic field at the target, which results in uniform heating profile. Operating the phases at different resonances deliver power at different frequencies. The winding and drive structure developed in this paper can be applied to many other applications, including chargers and wireless power delivery systems.
Interpretation of biological experiments changes with evolution of the Gene Ontology and its annotations (2018)

Gene Ontology (GO) enrichment analysis is ubiquitously used for interpreting high throughput molecular data and generating hypotheses about underlying biological phenomena of experiments. However, the two building blocks of this analysis - the ontology and the annotations - evolve rapidly. We used gene signatures derived from 104 disease analyses to systematically evaluate how enrichment analysis results were affected by evolution of the GO over a decade. We found low consistency between enrichment analyses results obtained with early and more recent GO versions. Furthermore, there continues to be a strong annotation bias in the GO annotations where 58% of the annotations are for 16% of the human genes. Our analysis suggests that GO evolution may have affected the interpretation and possibly reproducibility of experiments over time. Hence, researchers must exercise caution when interpreting GO enrichment analyses and should reexamine previous analyses with the most recent GO version.
10th Biennial Helene Harris Memorial Trust Meeting (2006)

Improving the prognosis of ovarian cancer patients is a major challenge to scientists and clinicians. At a recent multidisciplinary meeting in Washington DC, advances in identification of precursor lesions, progress in disease biomarkers and animal models, the promise of nanotechnology, and strategies for manipulation of the innate and adaptive immune response offered prospects for real progress in this difficult-to-treat disease.
Facing Two T Cell Epitopes: A Degree of Randomness in the Primary Response Is Lost Upon Secondary Immunization (2000)

We have analyzed the hierarchy of epitope-specific T cell populations during a primary and a secondary CD8 T cell response. MHC-peptide tetramers were used to track the in vivo kinetics of expansion of T cell populations specific for two Kd-restricted epitopes simultaneously presented by a murine tumor cell following primary or recall immunizations. Individual syngeneic mice generated remarkably different primary CTL responses, as reflected by up to 60-fold differences in the relative contribution of each peptide-specific T cell population to the overall response. In these primary immunizations, the CTL dominance was not dictated by the respective abundance of the presented epitopes. In sharp contrast, the secondary response was systematically associated with a selective expansion of the same epitope-specific population both in vitro and in vivo. In vitro experiments indicated that the extent of expansion of each epitope-specific memory population is modulated by the epitope density. We conclude that, at least for this set of epitopes, the CTL hierarchy is not controlled by the same parameters in a primary vs a secondary response.
Innovative advanced nanotechnology test mask for chemical and mechanical planarization process prediction (2014)

There is an urgent need to provide a new Chemical Mechanical Planarization (CMP) test mask standard to the CMP development community. Updated test mask geometries are required to maintain relevance for 14 nm and beyond R&D. One of the key historical challenges to successfully generating a test mask offering was ensuring critical feedback from across the development user community. This feedback is essential to build a well-accepted test standard that captures critical CMP effects and allows process benchmarking and comparison. This was previously achieved by deep collaboration between industry consortia, academia, and a state-of-the-art research and development facility. The SUNY Polytechnic Institute's College of Nanoscale Science and Engineering (CNSE) and SEMATECH have joined together to develop a next generation CMP test vehicle, and are using the proven collaboration model to design an industry validated, technologically relevant mask set and test structure offering. The mask will include legacy structures similar to the original SEMATECH/MIT mask standard, but will focus on providing advanced structures and designs necessary to address today's CMP challenges.
Injection-Site Reactions to Booster Doses of Acellular Pertussis Vaccine: Rate, Severity, and Anticipated Impact (2003)

We conclude that injection-site reactions are more extensive after the fifth consecutive dose of an aP combination vaccine compared with the fifth dose in a mixed series of whole-cell and aP combination vaccines. These reactions are unlikely to affect parental acceptance of immunization recommendations or health care utilization.
Dielectric characterization of paraelectric particle-loaded polymer matrix composites and commercial photoresins at W-band frequencies (2023)

This work presents W-band (75-110 GHz) dielectric characterization of commercially available photoresins in their neat state, as well as in polymer matrix composite (PMC) mixtures with various loading concentrations of the paraelectric barium strontium titanate (BST). Due to difficulties 3D printing the BST-loaded PMC resins detailed within, a custom curing and casting process was used to fabricate testable PMC samples, which were synthesized to demonstrate the dielectric functionalization of the underlying polymer matrix. Dielectric characterization of the PMCs confirmed the functionalization of our composites when compared to the commercial photoresins. For example, a volumetric loading concentration of 25 vol % BST increased the dielectric permittivity (<i>ε<sub>r</sub></i> ) from 2.78 to 9.60 and the loss tangent (tanδ) from 0.022 to 0.114. These results indicate that the realization of UV-cured photoresins with "designer-dielectric" functionalization based on vol % of filler are strong candidates for use in stereolithography (SLA) 3D printing applications. To accomplish this, and with a special interest for radio/microwave/terahertz (RF/MW/THz) applications, we highlight the need for both (a) better photoresin matrix materials with lower intrinsic tanδ and (b) selection criteria related to the size/geometry and electronic properties of potential filler materials to maintain the printability of PMC photoresins in SLA systems.
LOP35 (2013)

Brölsch, G. F.1; Golberg, A.1; Bohr, S.1; Mihm, M.2; Albadawi, H.1; Watkins, M. T.1; Yarmush, M. L.1; Austen, W. G. Jr1Author Information
Adaptive ECC for Tailored Protection of Nanoscale Memory (2016)

Following technology scaling, runtime failure has emerged as one of the major challenges in modern VLSI designs under the increased parametric variability and low supply voltage. This issue is especially severe in nanoscale memory due to its high density and large capacity. In this work the authors present a novel reconfigurable Error Correction Code (ECC) to improve the reliability of nanoscale memory. <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">—Yiran Chen, University of Pittsburgh</i>
Comparing the fluctuations of the intrinsically disordered C-terminal domain of human SELK free in water and in lipid membrane (2015)

SELK is a single-pass trans-membrane protein that resides in the endoplasmic reticulum membrane (ER) with a C-terminal domain exposed to the cytoplasm that is known to interact with different components of the endoplasmic reticulum associated to the protein degradation (ERAD) pathway. This protein is resulted to be up-expressed in hepatocellular carcinoma and in other cancers, therefore there is a need to analyze its structure-function relationships. In this work we performed a detailed analysis of the C-terminal domain sequence of SELK, modeled its three-dimensional structure and analyzed its conformational changes by Molecular Dynamics simulations. Our analysis showed that the C-terminal domain of SELK is a weak polyelectrolyte and specifically, a polycation, which has the characteristic molecular signature of natively disordered segments. Since the search by BLAST has not evidenced possible templates with an acceptable sequence identity percentage with the C-terminal sequence of SELK, its three-dimensional structure was modeled by ab initio modeling. The best model is characterized by one short helix and the most part of residues with no regular secondary structure elements. This model was subjected to MD simulation at neutral pH in water to assess the stability of the modelled structural organization free in solution. To deepen the structural analysis of the C terminal domain, we have also studied the organization of the whole protein inserted into the membrane by a procedure of comparative modeling between fold recognition and folding ab initio. Then, the complete structure of SELK was subjected to MD simulations in the lipid bilayer and a water box. Analyzing the MD trajectories, we found that the C-terminal domain of SELK is still highly mobile during the simulation in water-lipid bilayer by showing a decrease of the structural compactness, a lesser number of H-bonds, as well as a higher value of the total void volume and of the total solvent accessible area compared to the simulation in only water system. However, in both the simulations this region is stabilized mainly by a marked number of H-bonds, and pi-cation and IAC interactions, which suggest a globule organization very different from the classic globular one. Furthermore, water-protein interaction data suggest, as for other IDPs, that the hydration water tends to cluster around the protein facilitating its organization to globule.