gebhart/patrepeval huggingface dataset:
Characterization of spatio-temporal dynamics of deformable mirrors (2018)

Innovative technologies are needed to support and augment the development of various types of deformable mirrors (DM), such as Micro Electro Mechanical Systems (MEMS), segmented, bimorph and membrane types that are currently used in adaptive-optic (AO) systems. The paper discusses the results of initial studies that, could, potentially, be employed for full characterization of the dynamic behavior of adaptive optics mirrors. The experimental data were obtained from a typical bimorph mirror using both, a Shack-Hartman wavefront sensor (SHWFS) and an Imaging Laser Doppler Vibrometer (ILDV) developed exclusively by AS&amp;T Inc. These two sensors were employed for quantitative measurement of both the spatial and temporal dynamics of the DM under broadband excitation via the piezo electric drive elements. The need to characterize the spatial and temporal dynamic response of current and future DM mirror designs is essential for optimizing their performance to a level adequate for high bandwidth AO systems, such as those employed for real-time compensation of wavefront perturbations.
Genetically Related Choriocarcinoma Developing 5 Yr After a Complete Hydatidiform Mole and Simulating a Cornual Ectopic Pregnancy (2019)

Persistent gestational trophoblastic disease can arise from any type of antecedent pregnancy, including molar and tubal pregnancies. While most cases of persistent gestational trophoblastic disease present within the first year following initial diagnosis, recurrence has rarely been reported many years after initial diagnosis. Distinguishing recurrence from a new independent lesion is clinically important. A 25-yr-old woman presented with a mass in the right uterine cornu that was discontiguous with the endometrial cavity and was associated with an elevated serum human chorionic gonadotropin level. She had a history of an invasive complete hydatidiform mole with lung involvement treated with chemotherapy 5 yr prior. Wedge resection of the right cornu was performed due to concern for a cornual ectopic pregnancy. Pathologic evaluation demonstrated a choriocarcinoma. Molecular genotyping confirmed the tumor as recurrent disease genetically related to the prior complete hydatidiform mole. She completed 4 cycles of EMA-CO therapy, and has been disease-free with undetectable serum human chorionic gonadotropin level for 2 yr.
Anticipatory life-cycle assessment of supercritical fluid synthesis of barium strontium titanate nanoparticles (2016)

The life-cycle impacts of the supercritical fluid synthesis production of barium strontium titanate nanoparticles were assessed at the lab-scale and compared to conventional synthesis methods.
Comparison of in situ ionizing radiation effects on Raman and photoluminescence intensity of high OH, low OH silica, and fluoride core fibers (1995)

An in situ study of the effects of ionizing radiation on the strength of the Raman and photoluminescence signal of high OH, low OH, and fluoride core fibers has been performed with 514.5 nm laser excitation. The fibers were irradiated with a 60Co source at a constant dose rate of 560 rads/h. The high OH fiber displayed a much slower decay of the fiber Raman intensity than the other two fibers during irradiation. The fluoride fiber exhibited the quickest decline in Raman signal with the intensity dropping by a factor of 1000 in less than 20 min. The Raman intensity of the low OH silica fiber recovered to greater than 90% of its pre-irradiation value after a post-irradiation photoanneal with 488 nm laser light. The silica fibers displayed an increase in intensity of a broad photoluminescence feature centered at 650 nm. However the fiber photoluminescence intensity remained much weaker than the Raman intensity throughout the irradiations.
[Continuous Holter cardiac monitoring and chemotherapy by combination with platinum and fluoro-uracil]. (1991)

Thirty-three male patients (pts) were given cisplatin and fluoro-uracil (1 g/m2/d) in IV continuous infusion over 96 h, for the primary or palliative treatment of locally advanced head and neck cancer. The mean age was 52 +/- 7 years (range: 37-65). Patients underwent continuous ECG monitoring and were monitored for 22.4 +/- 1.5 h before FU infusion, 91.9 +/- 7.3 h during FU infusion and 18.5 +/- 2 h after 5FU infusion. Patients were given one cycle of chemotherapy (32 pts), two (25 pts) or three consecutive cycles (20 pts). Seventeen pts (53%) had supraventricular arrythmia, 15 pts (47%) had ventricular arrythmia and 10 pts (31%) had ST segment deviation. The ECG abnormalities were more frequent during the first cycle of chemotherapy. No previous clinical or ECG parameter was associated to ECG changes. Platin-induced hypomagnesemia and hypokaliemia probably increase incidence of cardiac abnormalities, during and after FU infusion.
A Common Protocol for Implementing Various DHT Algorithms (2006)

This document defines DHT-independent and DHT-dependent features of DHT algorithms and presents a comparison of Chord, Pastry and Kademlia. It then describes key DHT operations and their information requirements.
Torin1 mediated TOR kinase inhibition reduces Wee1 levels and advances mitotic commitment in fission yeast and HeLa cells (2014)

The target of rapamycin (TOR) kinase regulates cell growth and division. Rapamycin only inhibits a subset of TOR activities. Here we show that in contrast to the mild impact of rapamycin on cell division, blocking the catalytic site of TOR with the Torin1 inhibitor completely arrests growth without cell death in Schizosaccharomyces pombe. A mutation of the Tor2 glycine residue (G2040D) that lies adjacent to the key Torin-interacting tryptophan provides Torin1 resistance, confirming the specificity of Torin1 for TOR. Using this mutation, we show that Torin1 advanced mitotic onset before inducing growth arrest. In contrast to TOR inhibition with rapamycin, regulation by either Wee1 or Cdc25 was sufficient for this Torin1-induced advanced mitosis. Torin1 promoted a Polo and Cdr2 kinase-controlled drop in Wee1 levels. Experiments in human cell lines recapitulated these yeast observations: mammalian TOR (mTOR) was inhibited by Torin1, Wee1 levels declined and mitotic commitment was advanced in HeLa cells. Thus, the regulation of the mitotic inhibitor Wee1 by TOR signalling is a conserved mechanism that helps to couple cell cycle and growth controls.
Redox-active polymer-nanoparticle hybrid materials (2000)

Abstract Ring-opening metathesis polymerization was used to modify organic soluble gold nanoparticles with redox-active polymers. A gel-permeation chromatography study revealed that each nanoparticle is modified with approximately 11 polymer chains. Electrochemical studies of nanoparticles modified with block copolymers of two different redox-active groups revealed that each monomer is electrochemically accessible, while no current rectification was observed.
Generation of Heteroatom-Substituted Carbene Complexes of Iridium by Double C−H Activation of Ether and Amine Substrates (2000)

Regioselective, double C−H activation of a variety of ether and amine substrates, as exemplified with an ether in [Eq. (1)], is effected by the IrI compound [Ir(κ3-TpPh)(η4-isoprene)]). The formation of the corresponding Fischer-type carbenes follows the activation reaction. TpPh=hydridotris(3-phenylpyrazol-1-yl)borate. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2000/z14616_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Stereochemistry of palytoxin. Part 1. C85-C115 segment (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereochemistry of palytoxin. Part 1. C85-C115 segmentL. L. Klein, W. W. McWhorter, S. S. Ko, K. P. Pfaff, Y. Kishi, D. Uemura, and Y. HirataCite this: J. Am. Chem. Soc. 1982, 104, 25, 7362–7364Publication Date (Print):December 1, 1982Publication History Published online1 May 2002Published inissue 1 December 1982https://pubs.acs.org/doi/10.1021/ja00389a098https://doi.org/10.1021/ja00389a098research-articleACS PublicationsRequest reuse permissionsArticle Views448Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Interleukin-1 (IL-1) receptor antagonist prevents Staphylococcus epidermidis-induced hypotension and reduces circulating levels of tumor necrosis factor and IL-1 beta in rabbits (1993)

Similar to shock in gram-negative sepsis, shock from gram-positive organisms is mediated, in part, by tumor necrosis factor (TNF) and interleukin-1 (IL-1). In the present study, rabbits were infused with IL-1 receptor antagonist (IL-1ra) prior to and during Staphylococcus epidermidis-induced hypotension. After injection of bacteria, a maximal fall in mean arterial pressure to -42% below baseline occurred at 200 min in vehicle-treated animals compared with a nonsignificant decrease of only 7% in the IL-1ra-treated group (P < 0.01, vehicle versus IL-1ra). A similar attenuation was observed in the fall in systemic vascular resistance (P < 0.05). After the injection of S. epidermidis, TNF levels rose to a peak elevation of 475 +/- 160 U/ml in vehicle-treated rabbits, but in rabbits receiving IL-1ra, maximal TNF levels rose only to 85 +/- 23 U/ml (P < 0.01). Plasma IL-1 beta reached maximal concentrations at 180 min of 364 +/- 71 pg/ml in vehicle-treated animals but only 145 +/- 12 pg/ml in rabbits given IL-1ra (P < 0.05). The reductions in TNF and IL-1 were not due to interference by IL-1ra in the respective assays. In vitro, IL-1ra inhibited S. epidermidis-induced TNF from mononuclear cells by 31% +/- 11%, from spleen cells by 17% +/- 4% (P < 0.05), and from whole blood by 42% +/- 17%. Despite the near reversal of the fall in mean arterial pressure and systemic vascular resistance in IL-1ra-treated rabbits, leukopenia and thrombocytopenia were unaffected. These results demonstrate that IL-1ra blocks shock-like hemodynamic parameters and reduces circulating IL-1 and TNF levels in a model of gram-positive sepsis.
Le port franc d'Anvers (2008)

http://www.editions-universite-bruxelles.be/fiche/view/2422
Abstract 16232: Optimal Cut-Off Value for Fractional Flow Reserve Derived From Coronary Computed Tomography Angiography for Predicting Hemodynamically Significant Coronary Artery Disease (2017)

Introduction: Fractional flow reserve (FFR) derived from coronary computed tomography angiography (CT) is a novel less invasive diagnostic tool for detecting hemodynamically significant coronary ar...
Effects of partially reduced graphene oxide on the enzymatic activity of thrombin (2020)

Previously we had demonstrated that partially reduced graphene oxide (pRGO) enhances the enzymatic activity of microbial transglutaminase on the cross-linking of gelatin. In order to determine if this is a more general phenomenon in modification of enzymatic activity, we tested whether it has an effect on thrombin’s ability to clot fibrinogen. Thrombin, the enzyme responsible for
Activation of human B lymphocytes by nanogram concentrations of anti‐IgM‐dextran conjugates (1990)

Surface immunoglobulin (sIg) cross-linking on B lymphocytes by high concentrations of anti-Ig antibody has been used to mimic antigen-stimulated B cell activation. In order to develop a system to study sIg-mediated T cell-independent B cell activation using low concentrations of anti-Ig antibody that more closely resemble the concentrations of antigen that are achieved under in vivo conditions, we conjugated monoclonal anti-human IgM antibody (anti-mu) to dextran (molecular weight 2 X 10(6)) thereby increasing its valency. This dextran conjugate (anti-mu-Dex) stimulated comparable levels of thymidine incorporation and B cell size increases as were seen with unconjugated anti-mu but at 100- to 1000-fold lower concentrations. Anti-mu-Dex also stimulated increases in intracellular ionized calcium ([Ca2+]i) in a higher percentage of cells, of greater magnitude and of longer duration than that stimulated by unconjugated anti-mu. Interestingly, there was no direct correlation between the increases in [Ca2+]i that were stimulated by anti-mu-Dex and its ability to stimulate B cell proliferation. The concentrations of anti-mu-Dex (10 micrograms/ml) that led to the highest increase in [Ca2+]i resulted in thymidine incorporation that was no greater than that of medium control, whereas 0.01 to 0.1 microgram/ml stimulated significant thymidine incorporation with 50% lower levels of stimulation of [Ca2+]i. These data demonstrate that anti-mu-Dex is a potent activator of human B lymphocytes, is effective even at ng/ml concentrations which over a 2-h time period do not induce detectable modulation of sIg, and its stimulation of B cells into G1 and S may not be directly related to its ability to stimulate increases in levels of [Ca2+]i.
Theshort armofchromosome 11isa"hotspot" for hypermethylation inhumanneoplasia ANDRtEDE BUSTROS*, BARRYD.NELKIN*, ANNSILVERMAN*, GARTHEHRLICHt, BERNARDPOIESZt, (1988)

Inactivation ofnormally expressed genes may playarole intheformation and/or progression ofhuman cancers. Methylation ofcytosine inDNA could potentially participate insuchalterations ofgeneexpression. Abnormal- ities inDNA methylation areaconsistent feature ofhuman neoplasms, andwenowshowthatthese include notonly previously recognized widespread genomic hypomethylation, butalso regional increases ingenemethylation. Ahotspot for abnormal methylation ofC+G-rich areas hasbeendetected on theshort armofchromosome 11inanareaknowntoharbor tumorsuppressor genes. Thischange occurs consistently in commonforms ofhumancancer andappears early during the transformation ofcells withviruses including members ofthe humanT-cell leukemia (HTLV)family. Furthermore, inone chromosome 11gene examined, calcitonin, theincreased meth- ylation insomatic tumor cells coincides with thepresence ofan inactive chromatin pattern inthetranscriptional regulatory area. Theincreased regional DNAmethylation demonstrated maythenparticipate inormarkchromosomal changes asso- ciated withgeneinactivation events that arecentral tothe genesis and/or progression ofhumancancers.
The impact of semiconductor surface states on vacuum field emission (2022)

This work presents a theoretical analysis of the impact of surface states on vacuum field emission currents in semiconductors. In wide and ultra-wide bandgap semiconductors such as GaN and AlGaN, low electron affinity has been proposed as a benefit for field emission into vacuum. However, in these materials, the surface Fermi level at the surface is pinned well below the conduction band, and the surface depletion barriers due to the surface Fermi level pinning can be comparable to or higher than the electron affinity. Therefore, analysis of field emission requires consideration of not only the vacuum potential barrier set by electron affinity, but also the depletion region near the semiconductor surface. In this paper, we develop analytical models to predict field emission currents with careful consideration of the impact of surface states on the energy band alignment. The results are used to provide guidelines for design of field emitters that could benefit from the low electron affinity of semiconductors such as Al(Ga)N.
Automated data collection for electron tomography (1992)

Three-dimensional imaging has become an important addition to the variety of methods available for research on biological structures. Non-crystalline samples can be examined by high resolution electron tomography which requires that projection data be collected over a large range of specimen tilts. Practical limitations of tomography are set by the large number of micrographs to be processed, and by the required (and tedious) recentering and refocusing of the object during data collection; especially for dose sensitive specimens. With automated electron tomography a number of these problems can be overcome. First, the images are recorded directly in digital format, using a cooled slow scan CCD camera, and, with automatic tracking and correction for image shift and focus variation, a pre-aligned dataset is obtained, with every image recorded under well defined imaging conditions. At UCSF, we use intermediate voltage electron tomography to study higher-order chromatin structure. Of central interest is elucidating the higher-order arrangement of the 30nm chromatin fiber within condensed chromosomes through several phases of the cell cycle and, in collaboration with Chris Woodcock, the structure of the 30 nm fiber.
Extracorporeal Photophoresis in Reduced Intensity Conditioning: 14 Year Follow-up of 206 Patients Reveals an Efficacious Regimen with Low Rates of GVHD (2015)

Extracorporeal photopheresis (ECP) modulates host antigen presenting cells implicated in graft versus host disease (GVHD) development. Incorporation of ECP into a reduced intensity conditioning (RIC) regimen may prevent acute (a) and chronic (c) GVHD. Data were collected from Tufts Medical Center BMT and Center for International Bone Marrow Transplantation Registry (CIBMTR) databases. All patients who received PPT conditioning (ECP on days -6 and -5, Pentostatin on days -4 and -3, 600 cGy TBI on days -2 and -1) at Tufts between 10/1999–12/2013 were included. Cyclosporine and methotrexate were used for GVHD prophylaxis. 206 pts (56% male) received PPT. Median age was 53 (19-70) with 45% > 55. Median time from diagnosis to transplant was 17 months (1-180). 59% had matched related donors. Marrow was the stem cell source in 72%. 8% of transplants were mismatched at 1 antigen. Most common indications were Acute Myeloid Leukemia (AML) (35%), Myelodysplastic Syndrome (16%) and Non-Hodgkin Lymphoma (12%). Of the 73 pts with AML, 33% were in first complete remission (CR1), 18% were in a second or greater complete remission (CR ≥2) and 49% had active disease. Median times to neutrophil and platelet engraftment were 17 and 19 days, respectively. Grade 3-4 aGVHD occurred in 20% and 14% in the total cohort and AML subset respectively. cGVHD developed in 54% (17% extensive stage) and 35% (8% extensive stage) of pts in the total cohort and AML subset respectively. The 5 year OS for the entire cohort was 29% [95% CI (23%-36%)], and varied by diagnosis (Fig 1). NRM at 100 days was 17% [95% CI (13%-23%)]. On univariate analysis of the entire cohort, only 1-antigen mismatch [HR 1.96, p-value=0.01] and KPS <80 [HR 10.66, p-value <0.001] were associated with worse OS. In the AML cohort, active disease at HSCT (HR 2.43 p=0.001), failure to engraft (HR 4.84 p<0.001), and grade 3-4 aGVHD (4.08 p<0.001) were associated with worse OS. In multivariate analysis after stepwise selection, advanced age (aHR 1.36, p=0.04), active disease (aHR 2.46, p-value=0.003) (Fig 2), engraftment syndrome (aHR 43, p=0.001) and grade 3-4 aGVHD (aHR 5.23 p<0.001) were associated with worse OS. We report over a decade of experience with the PPT regimen. OS and low NRM are similar to other reported RIC regimens despite high rates of active disease at HSCT. Rates of severe acute and extensive chronic GVHD were low. PPT remains a viable regimen for pts not eligible for myeloablative conditioning.Figure 2Overall Survival of AML Patients by Remission Status.View Large Image Figure ViewerDownload Hi-res image Download (PPT)
27Al MAS NMR and XAS cross-study of the aluminophosphonate Al(OH)(O3PC6H5)Electronic supplementary information (ESI) available: X-ray powder diffraction pattern of Al(OH)(O3PC6H5). See http://www.rsc.org/suppdata/nj/b1/b106545a/ (2001)

An aluminium phenylphosphonate, Al(OH)(O3PC6H5), has been studied. Its poor long-range crystallographic organisation required the use of local probe techniques such as 31P and 27Al MAS NMR and XAS. An unexpectedly narrow and symmetric 27Al MAS NMR signal was obtained, with an isotropic chemical shift that has not been observed earlier in aluminium phosphonates. XANES and EXAFS studies showed unambiguously that this signal had to be attributed to a five-fold coordination site, the first observed for a phosphonato-aluminium atom.
Modular multilevel converter modelling, control and analysis under grid frequency deviations (2013)

A tool for component sizing for MMCs has been developed and tested through simulations in PLECS. The steady-state behaviour under grid frequency deviations — interesting for offshore wind farm connections — has been analysed, providing insights in MMC characteristics and further testing the proposed tool.
Alzheimer's Disease-related Overexpression of the Cation-dependent Mannose 6-Phosphate Receptor Increases Aβ Secretion (2002)

Prominent endosomal and lysosomal changes are an invariant feature of neurons in sporadic Alzheimer's disease (AD). These changes include increased levels of lysosomal hydrolases in early endosomes and increased expression of the cation-dependent mannose 6-phosphate receptor (CD-MPR), which is partially localized to early endosomes. To determine whether AD-associated redistribution of lysosomal hydrolases resulting from changes in CD-MPR expression affects amyloid precursor protein (APP) processing, we stably transfected APP-overexpressing murine L cells with human CD-MPR. As controls for these cells, we also expressed CD-MPR trafficking mutants that either localize to the plasma membrane (CD-MPRpm) or to early endosomes (CD-MPRendo). Expression of CD-MPR resulted in a partial redistribution of a representative lysosomal hydrolase, cathepsin D, to early endosomal compartments. Turnover of APP and secretion of sAPPalpha and sAPPbeta were not altered by overexpression of any of the CD-MPR constructs. However, secretion of both human Abeta40 and Abeta42 into the growth media nearly tripled in CD-MPR- and CD-MPRendo-expressing cells when compared with parental or CD-MPRpm-expressing cells. Comparable increases were confirmed for endogenous mouse Abeta40 in L cells expressing these CD-MPR constructs but not overexpressing human APP. These data suggest that redistribution of lysosomal hydrolases to early endocytic compartments mediated by increased expression of the CD-MPR may represent a potentially pathogenic mechanism for accelerating Abeta generation in sporadic AD, where the mechanism of amyloidogenesis is unknown.