gebhart/patrepeval huggingface dataset:
Apelin affects the mouse aging urinary peptidome with minimal effects on kidney (2019)

Kidney function is altered by age together with a declined filtration capacity of 5-10% per decade after 35 years. Renal aging shares many characteristics with chronic kidney disease. Plasma levels of the bioactive peptide apelin also decline with age and apelin has been shown to be protective in chronic kidney disease. Therefore we evaluated whether apelin could also improve aging-induced renal lesions and function in mice. Since urine is for the major part composed of proteins and peptides originating from the kidney, we first studied apelin-induced changes, in the aging urinary peptidome. Despite the recently published age-associated plasma decrease of apelin, expression of the peptide and its receptor was increased in the kidneys of 24 months old mice. Twenty-eight days treatment with apelin significantly modified the urinary peptidome of 3 and 24 months old mice towards a signature suggesting more advanced age at 3 months, and a younger age at 24 months. The latter was accompanied by a decreased staining of collagen (Sirius red staining) in 24 months old apelin-treated mice, without changing aging-induced glomerular hypertrophy. In addition, apelin was without effect on aging-induced renal autophagy, apoptosis, inflammation and reduced renal function. In conclusion, treatment of aged mice with apelin had a limited effect on kidney lesions although modifying the urinary peptidome towards a younger signature. This supports evidence of apelin inducing more general beneficial effects on other aging organs, muscles in particular, as recently shown for sarcopenia, markers of which end up via the glomerular filtration in urine.
A Simple, Efficient Synthetic Route to Sr2Si5N8:Eu2+-Based Red Phosphors for White Light-Emitting Diodes (2006)

This paper reports a simple, inexpensive, and high-yield synthetic route to Sr2Si5N8:Eu2+-based red nitridosilicate phosphors for white light-emitting diodes (LEDs). Through the chemical reaction of SrCO3, Eu2O3, and Si3N4 rather than the air-sensitive Sr, Eu, Si(NH)2, Sr3N2, and EuN powders, a complex phosphor consisting of Sr2Si5N8:Eu2+ (∼64 wt %) and Sr2SiO4:Eu2+ (∼36 wt %) were obtained by firing the powder mixture at 1600 °C under 0.5 MPa N2. The structural characterization, luminescence spectra, quantum efficiency, and thermal quenching of the synthesized phosphor were investigated and compared with those of Sr2Si5N8:Eu2+ prepared by the conventional method. It shows that the emission of the existing Sr2SiO4:Eu2+ is extremely low (about 0.04% of that of Sr2Si5N8:Eu2+) under the ultraviolet-light irradiation, and it is silent under the blue-light excitation (λ = 400−480 nm); therefore, the luminescence of the complex phosphor solely arises from Sr2Si5N8:Eu2+. The Sr2Si5N8:Eu2+-based phosphor is orange-red in color and emits strongly in the red region of 616−670 nm depending on the Eu2+ concentration when excited at λ = 450 nm. Furthermore, the Sr2Si5N8:Eu2+-based phosphor synthesized by this novel method shows equivalent optical properties, such as high emission intensity, high quantum efficiency, and very low thermal quenching, with those prepared by the conventional approaches, allowing it a promising red luminescent material for white LEDs.
Adenosine stress perfusion CMR in young children: assessment of optimal imaging parameters (2013)

CMR adenosine stress perfusion can be performed in young children and images of diagnostic quality acquired. Young children present a number of technical challenges that can be overcome by appropriately adapting imaging parameters to the individual patient size.
On the internal quantum efficiency for InGaN/GaN light-emitting diodes grown on insulating substrates (2016)

The internal quantum efficiency (IQE) for InGaN/GaN light-emitting diodes (LEDs) grown on [0001] sapphire substrates is strongly affected by various factors including polarization effect in the InGaN/GaN multiple quantum wells (MQWs), insufficient electron and hole injections, low p-type GaN doping efficiency, carrier loss due to the Auger recombination, and current crowding effect especially for the hole current in the p-GaN region. In this work, the remedies taken by the scientific community to enhance the IQE are reviewed, compared and summarized. Meanwhile, this review also discusses alternative ways including polarization self-screening effect, polarization cooling, hole accelerator, and hole modulator. The structural solutions we propose in this work can better improve the device performance without increasing the processing difficulty significantly, and their effectiveness in improving the IQE is further supported by the numerical and experimental studies. For example, on the contrary to common belief, the polarizations in the [0001] oriented InGaN/GaN LEDs can be advantageously used to improve the device performance based on our designs.
A noble evaluation method for repaired area utilizing SEM images (2009)

In general photomask defect repair process flow, repaired portion is evaluated with AIMS<sup>TM</sup> and if AIMS<sup>TM</sup>'s result is out of specification, the repaired portion must be re-repaired. With shrinking pattern on device, tighter specification is required. Therefore re-repair cycle time increases and turn around time of defect repair process becomes much longer. To solve this problem, we propose a noble evaluation method that enables us to judge without using AIMS<sup>TM</sup> with repair tool images. Images of EB repair tool is available for our propose because EB repair tool dose not give any damage on substrate and the resolution of image is quite high compared to other repair tools, FIB and Nanomachining tool. We made lithography simulation and practical experiments with line & space pattern of ArFatt. PSM with programmed defects. Consequently, we can predict AIMS-Results immediately after repair and there is a possibility to reduce the turn around time of defect repair process.
Double-Skin Facades With Semi-Transparent Modules For Building Retrofit Actions: Energy And Visual Performances (2020)

The performances and the optimal configuration of new semi-transparent modules for Double-Skin Façade are investigated through the dynamic simulation software TRNSYS and Radiance. A sensitivity analysis is conducted upon varying the: (i) material typology, (ii) cavity depth and (iii) transparency of the materials used for the modules. The analysis highlights that, in comparison with the base case without Double-Skin Façade, the new modules can improve energy efficiency of buildings and indoor environmental quality. The analysis underlines also that the performances and the optimal configuration are strongly dependent on the boundary conditions as well as the material thermal and visual characteristics.
Methohexital Plasma Concentrations in Children Following Rectal Administration (1985)

Despite the increasing use of rectal methohexital as a premedicant-induction agent in pediatric anesthesia, there are no data to confirm the assumption that low plasma methohexital concentrations are the cause of inadequate sedation of children and that high concentrations are associated with the loss of consciousness. Plasma methohexital concentrations were determined in 20 ASA Class I children, ages 2-7 yr, after the rectal administration of methohexital (25 mg/kg). Seventeen of the 20 children in this study fell asleep after receiving the drug and achieved peak plasma concentrations greater than 2 micrograms/ml. The maximum plasma methohexital concentration in children that did not fall asleep was less than 2 micrograms/ml. The mean time to the onset of sleep after drug administration was 8.3 min (at which time the mean plasma concentration was 4.4 micrograms/ml). The mean peak plasma concentration and the mean time to peak plasma concentration were 4.7 micrograms/ml and 13.9 min, respectively. Loss of consciousness after rectal administration of methohexital correlates well with the plasma concentration of the drug.
Lethal persistent pulmonary hypertension of the newborn in Bohring–Opitz syndrome (2018)

Bohring-Opitz syndrome (BOS) is a rare disease with a number of characteristic features, including hypertelorism, prominent metopic suture, exophthalmos, cleft palate, abnormal posture, and developmental retardation. Here, we report a BOS patient presenting with lethal persistent pulmonary hypertension of the newborn (PPHN) and inspiratory respiratory failure. The female infant was treated with nitric oxide and vasodilator, which did not improve her condition. The inspiratory respiratory failure required management with deep sedation. She died on postnatal day 60 due to progressed heart failure. Whole exome sequencing revealed de novo mutation in the ASXL1 gene, c.1934dupG, p.Gly646TrpfsTer12.
Trap Assisted Stress Induced ESD Reliability of GaN Schottky Diodes (2018)

Electro-thermal behaviour and degradation of recessed GaN Schottky diode are studied under forward and reverse ESD stress. Impact of different surface treatments at Schottky interface, on trap generation and degradation is investigated. Evolution of mechanical stress and defects is probed using on-the-fly Raman spectroscopy. Distinct failure modes are discovered in each case.
A Glimpse in ChatGPT Capabilities and its impact for AI research (2023)

Large language models (LLMs) have recently become a popular topic in the field of Artificial Intelligence (AI) research, with companies such as Google, Amazon, Facebook, Amazon, Tesla, and Apple (GAFA) investing heavily in their development. These models are trained on massive amounts of data and can be used for a wide range of tasks, including language translation, text generation, and question answering. However, the computational resources required to train and run these models are substantial, and the cost of hardware and electricity can be prohibitive for research labs that do not have the funding and resources of the GAFA. In this paper, we will examine the impact of LLMs on AI research. The pace at which such models are generated as well as the range of domains covered is an indication of the trend which not only the public but also the scientific community is currently experiencing. We give some examples on how to use such models in research by focusing on GPT3.5/ChatGPT3.4 and ChatGPT4 at the current state and show that such a range of capabilities in a single system is a strong sign of approaching general intelligence. Innovations integrating such models will also expand along the maturation of such AI systems and exhibit unforeseeable applications that will have important impacts on several aspects of our societies.
Novel Low-Loss Photodefined Electrical TSVs for Silicon Interposers (2013)

Silicon interposers with through-silicon vias (TSVs) have been widely explored to connect multiple chips using high-density fine-pitch lateral interconnects. However, there are challenges with the TSVs in silicon interposers: (1) TSV losses increase as TSV height increases and are much higher in low-resistivity silicon substrates, which are more economical, than in high-resistivity silicon substrates, and (2) coefficient of thermal expansion (CTE) mismatch between the copper and silicon leads to stress generation. To address this set of challenges, we fabricated and characterized two novel photodefined TSVs for silicon interposers: polymer-clad TSVs and polymer-embedded vias. The fabricated polymer-clad TSVs consist of a ~20 μm thick photodefined dielectric liner instead of a 1 μm thin SiO2 liner, while the polymer-embedded vias consist of copper vias embedded in photodefined polymer wells within the silicon wafer. Compared to the conventional TSVs with thin (~1 μm) SiO2 liner, ~3.5X and ~20X reductions in TSV insertion loss can be obtained at 25 GHz using the fabricated polymer-clad TSVs and polymer-embedded vias, respectively. Full-wave EM simulations were performed in HFSS to compare the insertion loss of the novel TSVs with the conventional TSVs. With respect to the polymer-clad TSVs, in addition to the reduction in TSV insertion loss, a possible reduction in TSV stresses can be obtained using a low Young's modulus material for the thick liner. Finite-element modeling (FEM) simulations were performed in ANSYS to analyze the possible stress reduction that can be obtained using the fabricated polymer-clad TSVs compared to the conventional TSVs. Finally, four-point resistance measurements were performed for the novel TSVs to prove their high yield. In summary, this presentation will report fabrication and resistance measurements of the novel polymer-clad TSVs and polymer-embedded vias as well as HFSS and ANSYS simulations for the novel TSVs.
Construction of topography stations at SPring-8 and first observations (2001)

Two topography experimental stations are presently available at SPring-8. The first, constructed at the short-length bending magnet beam line BL28, is designed to perform white- and selected wide-energy-range x-ray topography. The other is a high-resolution diffraction topography station located on the medium-length bending magnet beam line BL20, where the incoming beam displays a large cross section and high degree of parallelism. This allows us to observe fine structures of three-dimensionally large crystals used in industry if high energy is employed. The construction concepts, as well as first, selected experimental results are presented.
R-PASS: A Fast Structure-Based RNA Sequence Alignment Algorithm (2011)

We present a fast pairwise RNA sequence alignment method using structural information, named R-PASS (RNA Pairwise Alignment of Structure and Sequence), which shows good accuracy on sequences with low sequence identity and significantly faster than alternative methods. The method begins by representing RNA secondary structure as a set of structure motifs. The motifs from two RNAs are then used as input into a bipartite graph-matching algorithm, which determines the structure matches. The matches are then used as constraints in a constrained dynamic programming sequence alignment procedure. The R-PASS method has an O(nm) complexity. We compare our method with two other structure-based alignment methods, LARA and ExpaLoc, and with a sequence-based alignment method, MAFFT, across three benchmarks and obtain favorable results in accuracy and orders of magnitude faster in speed.
Synthesis of chiral azamacrocycles using the bis(α‐chloroacetamide)s derived from chiral 1,2‐diphenylethylenediamine (1999)

Abstract Optically active diphenyl‐substituted tetraaza‐12‐crown‐4 diamide ( 10 ), tetraaza‐15‐crown‐5 diamide ( 12 ), tetraaza‐18‐crown‐6 diamide ( 11 ), and hexaaza‐18‐crown‐6 diamide ( 9 ) ligands were prepared by treating the appropriate secondary diamines with the ( R,R )‐ and ( S,S )‐ forms of 1,2‐bis( N ‐methyl‐α‐chloracetamido)‐1,2‐diphenylethane ( 20 ). Macrocyclic diamides 9 and 10 were reduced to form the optically active diphenyl‐substituted hexaaza‐18‐crown‐6 ( 13 ) and tetraaza‐12‐crown‐4 ( 14 ), respectively. Reduction of macrocyclic diamide ligands 11 and 12 gave a complex mixture of products from which the desired tetraaza‐15‐crown‐5 and 18‐crown‐6 compounds could not be isolated. Dichloride 20 was prepared by treating the chiral forms of 1,2‐ diphenylethylenediamine with chloroacetic anhydride or chloroacetyl chloride. The crystal structures for the ( R,R )‐form of dichloride 20 and the ( S,S )‐forms of macrocycles 10 and 11 are reported.
RELEASE OF EPIDERMAL GROWTH-FACTOR TRANSFORMING GROWTH-FACTOR-ALPHA BY OVARIAN-TUMORS IN-VITRO (1994)

EGF-like activity was measured in media from 3-hour incubations of ovarian tissue from 27 patients with normal postmenopausal ovaries, malignant or benign epithelial tumours. EGF-like activity in the medium was measured using a radioreceptor assay. Malignant tumour tissue released significantly more EGF/TGF-alpha than benign tissues and aneuploid carcinomas more than diploid carcinomas. In spite of varying amounts of tumour cells there was a strong correlation in EGF/TCF-alpha release from the different tissue samples of each patient suggesting paracrine rather than autocrine regulation. The level of EGF-like activity may be a feature of the patient rather than of the tumour cells.
Solvent-washable polymer templated synthesis of mesoporous materials and solid-acid nanocatalysts in one-pot (2009)

We report a new and simple one-pot synthetic method to produce mesoporous silica and nanoporous solid acid catalyst capable of catalyzing pinacole-pinacolone rearrangement and esterification reactions, by preparing a solvent washable phosphonated triblock copolymer template and self-assembling it in the presence of alkoxysilane.
Precision Diagnosis of Electric Multiple Units for Performance Evaluation (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Pseudocapacitive Electrodes Produced By Oxidant-Free Polymerization of Pyrrole Between the Layers of 2D Titanium Carbide (MXene) (2016)

Pseudocapacitive electrodes based on electrochemically active organic materials are emerging for the energy storage applications. 1 Organic materials are renewable, relatively inexpensive, lightweight, and their electrochemical properties can be tuned by changing their functional groups. Despite aforementioned advantages, they tend to degrade rapidly upon cycling mainly due to their poor conductivity. One option to improve their cycling performance is to graft/deposit them onto conductive carbon particles. 2 Two-dimensional carbides and carbonitirides called MXenes, which generally offer metallic conductivity, may become a suitable option to replace carbon in pseudocapacitve electrodes to improve the electrochemical performance of the organic materials. 3,4 Herein, we present simultaneous intercalation, alignment and oxidant-free polymerization of the pyrrole between the Ti 3 C 2 T x MXene layers by mixing pyrrole monomer with the Ti 3 C 2 T x colloidal solution. The optimized composition of the resulting composite yielded high volumetric and gravimetric capacitances of 1000 F/cm 3 and 416 F/g, respectively, at 5 mV/s. Furthermore, excellent capacitance retention of 92% was observed after 25,000 cycles at 100 mV/s. 1. M. Boota et al., Adv. Mater. (2015). DOI: 10.1002/adma.201504705 2. M. Boota et al., ChemSusChem , 8 , 3576–3581 (2015) 3. M. R. Lukatskaya et al., Science. , 341 , 1502–1505 (2013) 4. M. Ghidiu, M. R. Lukatskaya, M.-Q. Zhao, Y. Gogotsi, and M. W. Barsoum, Nature , 516 , 78–81 (2014)
Effect of Inclining Angle, Bundling, and Surface Treatment on Synthetic Fiber Pull-Out from a Cement Matrix (1990)

Peer Reviewed
Cloning of a gene expressed during appressorium formation by Colletotrichum gloeosporioides and a marked decrease in virulence by disruption of this gene. (1995)

Appressorium formation in germinating Colletotrichum gloeosporioides is induced by the surface wax of its host. One of the genes expressed uniquely in C. gloeosporioides during appressorium formation induced by the host signal has been designated cap20, and this gene and its cDNA were cloned and sequenced. Nucleotide sequences of both revealed an open reading frame that could encode a 183-amino acid polypeptide that did not have significant homology with any known proteins. Reverse transcriptase-polymerase chain reaction detected cap20 gene transcripts at the infection front on the surface and within tomato fruits infected by C. gloeosporioides. Gene-disrupted mutants incapable of expressing cap20 showed a drastically decreased virulence on avocado and tomato fruits. These results suggest that cap20 plays a significant role in the infection of the host.
Transforming activities of the NUP98-KMT2A fusion gene associated with myelodysplasia and acute myeloid leukemia (2019)

Inv(11)(p15q23), found in myelodysplastic syndromes and acute myeloid leukemia, leads to expression of a fusion protein consisting of the N-terminal of nucleoporin 98 (NUP98) and the majority of the lysine methyltransferase 2A (KMT2A). To explore the transforming potential of this fusion we established inducible iNUP98-KMT2A transgenic mice. After a median latency of 80 weeks, over 90% of these mice developed signs of disease, with anemia and reduced bone marrow cellularity, increased white blood cell numbers, extramedullary hematopoiesis, and multilineage dysplasia. Additionally, induction of <i>iNUP98-KMT2A</i> led to elevated lineage marker-negative Sca-1<sup>+</sup> c-Kit<sup>+</sup> cell numbers in the bone marrow, which outcompeted wildtype cells in repopulation assays. Six <i>iNUP98-KMT2A</i> mice developed transplantable acute myeloid leukemia with leukemic blasts infiltrating multiple organs. Notably, as reported for patients, iNUP98-KMT2A leukemic blasts did not express increased levels of the <i>HoxA-B-C</i> gene cluster, and in contrast to KMT2A-AF9 leukemic cells, the cells were resistant to pharmacological targeting of menin and BET family proteins by MI-2-2 or JQ1, respectively. Expression of <i>iNUP98-KMT2A</i> in mouse embryonic fibroblasts led to an accumulation of cells in G1 phase, and abrogated replicative senescence. In bone marrow-derived hematopoietic progenitors, iNUP98-KMT2A expression similarly resulted in increased cell numbers in the G1 phase of the cell cycle, with aberrant gene expression of <i>Sirt1</i>, <i>Tert</i>, <i>Rbl2</i>, <i>Twist1</i>, <i>Vim</i>, and <i>Prkcd</i>, mimicking that seen in mouse embryonic fibroblasts. In summary, we demonstrate that <i>iNUP98-KMT2A</i> has <i>in vivo</i> transforming activity and interferes with cell cycle progression rather than primarily blocking differentiation.
Extensive regulation of the non‐coding transcriptome by hypoxia: role of HIF in releasing paused RNA pol2 (2013)

Hypoxia is central to both ischaemic and neoplastic diseases. However, the non-coding transcriptional response to hypoxia is largely uncharacterized. We undertook integrated genomic analyses of both non-coding and coding transcripts using massively parallel sequencing and interfaced this data with pan-genomic analyses of hypoxia-inducible factor (HIF) and RNApol2 binding in hypoxic cells. These analyses revealed that all classes of RNA are profoundly regulated by hypoxia and implicated HIF as a major direct regulator of both the non-coding and coding transcriptome, acting predominantly through release of pre-bound promoter-paused RNApol2. These findings indicate that the transcriptional response to hypoxia is substantially more extensive than previously considered.