gebhart/patrepeval huggingface dataset:
DaeMon: Architectural Support for Efficient Data Movement in Disaggregated Systems (2023)

Resource disaggregation offers a cost effective solution to resource scaling, utilization, and failure-handling in data centers by physically separating hardware devices in a server. Servers are architected as pools of processor, memory, and storage devices, organized as independent failure-isolated components interconnected by a high-bandwidth network. A critical challenge, however, is the high performance penalty of accessing data from a remote memory module over the network. Addressing this challenge is difficult as disaggregated systems have high runtime variability in network latencies/bandwidth, and page migration can significantly delay critical path cache line accesses in other pages. This paper conducts a characterization analysis on different data movement strategies in fully disaggregated systems, evaluates their performance overheads in a variety of workloads, and introduces DaeMon, the first software-transparent mechanism to significantly alleviate data movement overheads in fully disaggregated systems. First, to enable scalability to multiple hardware components in the system, we enhance each compute and memory unit with specialized engines that transparently handle data migrations. Second, to achieve high performance and provide robustness across various network, architecture and application characteristics, we implement a synergistic approach of bandwidth partitioning, link compression, decoupled data movement of multiple granularities, and adaptive granularity selection in data movements. We evaluate DaeMon in a wide variety of workloads at different network and architecture configurations using a state-of-the-art accurate simulator. DaeMon improves system performance and data access costs by 2.39$\times$ and 3.06$\times$, respectively, over the widely-adopted approach of moving data at page granularity.
The inhibitory effect of a Platycodon root extract on ultraviolet B-induced pigmentation due to a decrease in Kit expression (2014)

The signaling of stem cell factor (SCF) through its receptor Kit is known to play an important role in regulating cutaneous melanogenesis. In the course of UVB-induced pigmentation, the expression of membrane-bound SCF by epidermal keratinocytes is upregulated at an early phase and subsequently activates neighboring melanocytes via their Kit receptors. In order to identify effective skin-lightening materials, we screened botanical extracts to determine their abilities to diminish Kit expression in melanocytes. A Platycodon root extract was consequently found to have a remarkable inhibitory activity on Kit expression. When the extract was applied to three-dimensional human skin substitutes in vitro and to human skin in vivo after UVB irradiation, their pigmentation was significantly reduced, confirming the substantial contribution of the suppression of SCF/Kit signaling to preventing or inhibiting melanin synthesis. These data demonstrate that a Platycodon root extract is a promising material for a skin-lightening product to improve pigmentation-related diseases.
Donor Heart Treatment With COMP-Ang1 Limits Ischemia-Reperfusion Injury and Rejection of Cardiac Allografts (2015)

The major cause of death during the first year after heart transplantation is primary graft dysfunction due to preservation and ischemia-reperfusion injury (IRI). Angiopoietin-1 is a Tie2 receptor-binding paracrine growth factor with anti-inflammatory properties and indispensable roles in vascular development and stability. We used a stable variant of angiopoietin-1 (COMP-Ang1) to test whether ex vivo intracoronary treatment with a single dose of COMP-Ang1 in donor Dark Agouti rat heart subjected to 4-h cold ischemia would prevent microvascular dysfunction and inflammatory responses in the fully allogeneic recipient Wistar Furth rat. COMP-Ang1 reduced endothelial cell-cell junction disruption of the donor heart in transmission electron microscopy during 4-h cold ischemia, improved myocardial reflow, and reduced microvascular leakage and cardiomyocyte injury of transplanted allografts during IRI. Concurrently, the treatment reduced expression of danger signals, dendritic cell maturation markers, endothelial cell adhesion molecule VCAM-1 and RhoA/Rho-associated protein kinase activation and the influx of macrophages and neutrophils. Furthermore, COMP-Ang1 treatment provided sustained anti-inflammatory effects during acute rejection and prevented the development of cardiac fibrosis and allograft vasculopathy. These results suggest donor heart treatment with COMP-Ang1 having important clinical implications in the prevention of primary and subsequent long-term injury and dysfunction in cardiac allografts.
Estimating CoP Trajectories and Kinematic Gait Parameters in Walking and Running Using Instrumented Insoles (2017)

Quantitative analysis of the plantar pressure distribution during dynamic tasks can facilitate diagnosis of foot and ankle dysfunctions and prevent potential injuries by providing detailed information about weight bearing and weight shifting patterns. Traditional laboratory measurements are currently limited by high operating costs and lack of portability. The use of instrumented insoles capable of capturing kinematic and kinetic gait parameters as subjects perform out-of-the-lab dynamic activities is a promising approach to overcome these limitations. This letter introduces SportSole, a fully portable system that can measure spatiotemporal gait parameters and center of pressure (CoP) trajectories. Wearing the SportSole, nine able-bodied subjects completed a walking session followed by a running session, each consisting of 10 full laps along a 16-meter straight-line path. Accuracy and precision of CoP trajectories and kinematic parameters were assessed using an electronic walkway as the reference system. After calibration, mean deviations in the CoP were 0.61 ± 0.05 cm (RMSE ± SD) for walking and 0.72 ± 0.08 cm for running. Deviations in stride length, stride time, and velocity were 1.66 ± 0.18 cm, 0.006 ± 0.003 s, and 1.65 ± 0.10 cm/s for walking, 1.91 ± 0.19 cm, 0.01 ± 0.03 s, and 2.67 ± 0.38 cm/s for running. These promising results indicate that the proposed system has the potential to be used for out-of-the-lab gait analysis of walking and running.
Detection of Lesions Using Differential Rates of Speckle Decorrelation (2003)

Breast lesions that may be cancerous generally possess a higher elastic modulus than the surrounding tissue. Thus, they are sensed to move differently from the surrounding tissue during finger-based palpation. Since the palpation is subjective in nature, a method using ultrasound for detection of the differential motion associated with hard lesions is proposed. It is intended that regions of detected 'lump' be highlighted on top of a conventional B-mode image so that the user can positively associate palpated lumps with specific regions on the anatomical B-mode image. We detect the differential motion associated with a lesion by detecting a local abnormality in a map of image-to-image correlations as the transducer is swept in an elevational direction. Experiments were performed with three different tissue mimicking phantoms. The results indicate that the location of the mobile lesion can be successfully estimated whereas immobile lesions are not very detectable. This approach is simple and requires only a short period of time for each scan. It has practically no theoretical incremental cost.
Monitoring polyolefin modification along the axis of a twin-screw extruder. II. Maleic anhydride grafting (2000)

The physico-chemical phenomena developing along the screw axis of a twin-screw extruder during the grafting of maleic anhydride (MA) onto polyolefins [polyethylene (PE), ethylene–propylene rubber (EPM), and polypropylene (PP)] were investigated. For this purpose, sampling devices located along the extruder barrel were used to collect polymer samples that were subsequently characterized to follow the degrees of grafting and crosslinking or degradation. A similar evolution of MA grafting was observed regardless of the polyolefin type or MA and peroxide concentration when grafting was performed under identical conditions, that is, the same peroxide type and set temperature. A correlation between the MA grafting and the calculated peroxide decomposition was established. Chemical reactions occurred along the extruder axis until the peroxide was fully converted. More detailed quantitative measurements of the peroxide decomposition and MA grafting would allow the development of accurate process models. The final MA content depended on the polyolefin composition (PE > EPM ≫ PP). As expected for PE, crosslinking occurred in addition to grafting, but after a certain residence time, the PE network degraded. The PP viscosity reduction after MA grafting was due to the conversion of tertiary PP radicals into primary PP radicals after grafting. © 2000 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 38: 3919–3932, 2000
The Histone Deacetylase Inhibitor, Vorinostat, Reduces Tumor Growth at the Metastatic Bone Site and Associated Osteolysis, but Promotes Normal Bone Loss (2010)

Vorinostat, an oral histone deacetylase inhibitor with antitumor activity, is in clinical trials for hematologic and solid tumors that metastasize and compromise bone structure. Consequently, there is a requirement to establish the effects of vorinostat on tumor growth within bone. Breast (MDA-231) and prostate (PC3) cancer cells were injected into tibias of SCID/NCr mice and the effects of vorinostat on tumor growth and osteolytic disease were assessed by radiography, micro-computed tomography, and histologic and molecular analyses. Vorinostat-treated and control mice without tumors were also examined. Tumor growth in bone was reduced ∼33% by vorinostat with inhibited osteolysis in the first few weeks of the experiment. However, osteolysis became more severe in both the vehicle and vorinostat-treated groups. Vorinostat increased the expression of tumor-derived factors promoting bone resorption, including PTHrP, IL-8, and osteopontin. After 4 weeks of vorinostat therapy, the non-tumor-bearing contralateral femurs and limbs from vorinostat-treated tumor-free SCID mice showed significant bone loss (50% volume density of controls). Thus, our studies indicate that vorinostat effectively inhibits tumor growth in bone, but has a negative systemic effect reducing normal trabecular bone mass. Vorinostat treatment reduces tumor growth in bone and accompanying osteolytic disease as a result of decreased tumor burden in bone. However, vorinostat can promote osteopenia throughout the skeleton independent of tumor cell activity.
Straining strained molecules. II. The syntheses and spectral properties of some ace-bridged naphthalenes (1977)

Reaction of both peri-dilithionaphthalene and peri-dilithioacenaphthalene with acenaphthenequinone and pyracenequinone yielded the dihydroxy derivatives of acenaphth[1,2-a]-acenaphthylene 11a, 11b, 11c with no, one, and two ace-bridges respectively. These could be converted either by the Corey thionocarbonate method or with anhydrous liquid hydrogen fluoride to the three alkenes 12a,b,c and with Pb(OAc) 4 to the three diketones 13a,b,c. The latter on Wolff–Kishner reduction yielded alkenes 12a,b and mono ketones 15b,c. The uv, ir, 1 Hmr spectra and electrode reduction potentials for the four series of compounds in which the ace-bridges add increments of strain were examined and possible effects which might be due to strain were noted. Several areas in which theoretical calculations are lacking were noted.
Rapid diagnostic imaging of cancer using radiolabeled liposomes. (1997)

A novel tumor diagnostic imaging method was developed that allows tumor localization soon after administration of radiolabeled liposomes. Although previous studies showed that radiolabeled liposomes can reach various tumors in a short time, their blood clearance is slow, and the high blood background hinders early imaging. Therefore, we attempted to remove actively the liposomes from the circulation using the strong affinity between avidin and biotin. Liposomes that had biotin bound to their surface and were labeled with 111In, 67Ga, or 99mTc were administered to mice bearing sarcoma 180, followed by administration of avidin 2 or 4 h later. Avidin initiated liposomal aggregation, resulting in their rapid removal by the reticuloendothelial system. Consequently, their blood level was markedly reduced without any changes in tumor levels. The tumor-to-blood ratio reached about 13 at only 2.5 h after administration of 99mTc-labeled liposomes, versus 1.0 or less without postadministration of avidin. Increased liver accumulation was also observed, but it decreased gradually with time.
Base Peak (BP) (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Allosteric Molecular Switches in Metabotropic Glutamate Receptors (2020)

Metabotropic glutamate receptors (mGlu) are class C G protein-coupled receptors of eight subtypes that are omnipresently expressed in the central nervous system. mGlus have relevance in several psychiatric and neurological disorders, therefore they raise considerable interest as drug targets. Allosteric modulators of mGlus offer advantages over orthosteric ligands owing to their increased potential to achieve subtype selectivity, and this has prompted discovery programs that have produced a large number of reported allosteric mGlu ligands. However, the optimization of allosteric ligands into drug candidates has proved to be challenging owing to induced-fit effects, flat or steep structure-activity relationships and unexpected changes in theirpharmacology. Subtle structural changes identified as molecular switches might modulate the functional activity of allosteric ligands. Here we review these switches discovered in the metabotropic glutamate receptor family..
An α-helical peptidomimetic scaffold for dynamic combinatorial library formation (2016)

A novel oligobenzamide-based α-helix mimetic was designed and synthesised with either imine or hydrazone functionalities that serve both to pre-organise the side-chain vectors to mimic the i, i + 4 and i + 7 residues of an α-helix, and to allow for the facile creation of dynamic libraries.
BAW Technologies: Overview for wireless communication systems and potential impact on the next RF architectures (2007)

International audience
An IMS−IMS Analogue of MS−MS (2006)

The development of a new ion mobility/mass spectrometry instrument that incorporates a multifield drift tube/ion funnel design is described. In this instrument, individual components from a mixture of ions can be resolved and selected on the basis of mobility differences prior to collisional activation inside the drift tube. The fragment ions that are produced can be dispersed again in a second ion mobility spectrometry (IMS) region prior to additional collisional activation and MS analysis. The result is an IMS-IMS analogue of MS-MS. Here, we describe the preliminary instrumental design and experimental approach. We illustrate the approach by examining the highly characterized bradykinin and ubiquitin systems. Mobility-resolved fragment ions of bradykinin show that b-type ions are readily discernible fragments, because they exist as two easily resolvable structural types. Current limitations and future directions are briefly discussed.
How can the binder properties influence the road surface durability? An advanced method based on the bearing ratio curve (2009)

This chapter contains sections titled: Introduction Experimental procedure: Materials, Mechanical Solicitation and Surface Scanning Analysis Method Experimental Results Conclusion and prospects Acknowledgements References
Effects of variation in background mixing ratios of N 2 , O 2 , and Ar on the measurement of δ 18 O–H 2 O and δ 2 H–H 2 O values by cavity ring-down spectroscopy (2017)

Abstract. Cavity ring-down spectrometers have generally been designed to operate under conditions in which the background gas has a constant composition. However, there are a number of observational and experimental situations of interest in which the background gas has a variable composition. In this study, we examine the effect of background gas composition on a cavity ring-down spectrometer that measures δ18O–H2O and δ2H–H2O values based on the amplitude of water isotopologue absorption features around 7184 cm−1 (L2120-i, Picarro, Inc.). For background mixtures balanced with N2, the apparent δ18O values deviate from true values by −0.50 ± 0.001 ‰ O2 %−1 and −0.57 ± 0.001 ‰ Ar %−1, and apparent δ2H values deviate from true values by 0.26 ± 0.004 ‰ O2 %−1 and 0.42 ± 0.004 ‰ Ar %−1. The artifacts are the result of broadening, narrowing, and shifting of both the target absorption lines and strong neighboring lines. While the background-induced isotopic artifacts can largely be corrected with simple empirical or semi-mechanistic models, neither type of model is capable of completely correcting the isotopic artifacts to within the inherent instrument precision. The development of strategies for dynamically detecting and accommodating background variation in N2, O2, and/or Ar would facilitate the application of cavity ring-down spectrometers to a new class of observations and experiments.
Geometry-constrained Degrees of Freedom Analysis for Imaging Systems: Monostatic and Multistatic (2017)

In this paper, we develop a theoretical framework for analyzing the measurable information content of an unknown scene through an active electromagnetic imaging array. We consider monostatic and multistatic array architectures in a one-dimensional setting. Our main results include the following: (a) we introduce the space-bandwidth product (SBP), and show that, under the Born approximation, it provides an accurate prediction of the number of the degrees of freedom (DoF) as constrained by the geometry of the scene and the imaging system; (b) we show that both monostatic and multistatic architectures have the same number of DoF; (c) we show that prior DoF analysis based on the more restrictive Fresnel approximation are obtained by specializing our results; (d) we investigate matched-filter (back-propagation) and pseudoinverse image reconstruction schemes, and analyze the achievable resolution through these methods. Our analytical framework opens up new avenues to investigate image formation techniques that aim to reconstruct the reflectivity function of the scene by solving an inverse scattering problem, and provides insights on achievable resolution. For example, we show that matched-filter reconstruction leads to a significant resolution loss for multistatic architectures.
Distal anastomotic patency of the Cardica C-PORT® xA system versus the hand-sewn technique: a prospective randomized controlled study in patients undergoing coronary artery bypass grafting† (2013)

According to these preliminary results and despite the limited number of patients, the use of the C-Port xA® System is safe enough to perform distal end-to-side vein graft anastomosis, with respect to 12-month end-to-side distal venous anastomotic patency. Although there are some technical challenges with this device, the incidence of complications is comparable to the traditional hand-sewn technique.
Quantitative fluorescence lifetime spectroscopy in turbid media: comparison of theoretical, experimental and computational methods (2002)

A Monte Carlo model developed to simulate time-resolved fluorescence propagation in a semi-infinite turbid medium was validated against previously reported theoretical and computational results. Model simulations were compared to experimental measurements of fluorescence spectra and lifetimes on tissue-simulating phantoms for single and dual fibre-optic probe geometries. Experiments and simulations using a single probe revealed that scattering-induced artefacts appeared in fluorescence emission spectra, while fluorescence lifetimes were unchanged. Although fluorescence lifetime measurements are generally more robust to scattering artefacts than are measurements of fluorescence spectra, in the dual-probe geometry scattering-induced changes in apparent lifetime were predicted both from diffusion theory and via Monte Carlo simulation, as well as measured experimentally. In all cases, the recovered apparent lifetime increased with increasing scattering and increasing source-detector separation. Diffusion theory consistently underestimated the magnitude of these increases in apparent lifetime (predicting a maximum increase of approximately 15%), while Monte Carlo simulations and experiment were closely matched (showing increases as large as 30%). These results indicate that quantitative simulations of time-resolved fluorescence propagation in turbid media will be important for accurate recovery of fluorophore lifetimes in biological spectroscopy and imaging applications.
Machine Learning to Predict Risk of Relapse Using Cytologic Image Markers in Patients With Acute Myeloid Leukemia Posthematopoietic Cell Transplantation (2022)

The texture features extracted from chromatin patterns of myeloblasts can predict post-HCT relapse and prognosticate RFS of patients with AML/MDS.
Quantifying Information Leakage in Finite Order Deterministic Programs (2010)

Information flow analysis is a powerful technique for reasoning about the sensitive information exposed by a program during its execution. While past work has proposed information theoretic metrics (e.g., Shannon entropy, min-entropy, guessing entropy, etc.) to quantify such information leakage, we argue that some of these measures not only result in counter-intuitive measures of leakage, but also are inherently prone to conflicts when comparing two programs P1 and P2 -- say Shannon entropy predicts higher leakage for program P1, while guessing entropy predicts higher leakage for program P2. This paper presents the first attempt towards addressing such conflicts and derives solutions for conflict-free comparison of finite order deterministic programs.
Nanophotonic atomic-frequency-comb quantum memory based on a rare-earth doped photonic crystal cavity (2017)

We demonstrate an efficient atomic frequency comb quantum memory based on an impedance-matched nanophotonic cavity fabricated in an Nd doped YVO crystal. Storage of time-bin qubits with 97% fidelity is achieved.
Confluence of geodesics in Liouville quantum gravity for $\gamma \in (0,2)$ (2020)

We prove that for any metric, which one can associate with a Liouville quantum gravity (LQG) surface for $\gamma \in (0,2)$ satisfying certain natural axioms, its geodesics exhibit the following confluence property. For any fixed point $z$, a.s. any two $\gamma $-LQG geodesics started from distinct points other than $z$ must merge into each other and subsequently coincide until they reach $z$. This is analogous to the confluence of geodesics property for the Brownian map proven by Le Gall (Acta Math. 205 (2010) 287–360). Our results apply for the subsequential limits of Liouville first passage percolation and are an important input in the proof of the existence and uniqueness of the LQG metric for all $\gamma \in (0,2)$.