gebhart/patrepeval huggingface dataset:
Hardware verification at Computational Logic, Inc. (1990)

The following topics are covered in viewgraph form: (1) hardware verification; (2) Boyer-Moore logic; (3) core RISC; (4) the FM8502 fabrication, implementation specification, and pinout; (5) hardware description language; (6) arithmetic logic generator; (7) near term expected results; (8) present trends; (9) future directions; (10) collaborations and technology transfer; and (11) technology enablers.
Clinical Trial of a Plant-Derived Antibody on Recolonization of Mutans Streptococci (2005)

Plantibody is safe but not effective at the frequency, concentration, and number of applications used in this study.
λ-Cyhalothrin Resistance Detection in the German Cockroach (Blattodea: Blattellidae) (1999)

Journal Article λ-Cyhalothrin Resistance Detection in the German Cockroach (Blattodea: Blattellidae) Get access Steven M. Valles Steven M. Valles Center for Medical, Agricultural and Veterinary Entomology, USDA-ARS, 1600 S.W. 23rd Drive, Gainesville, FL 32608 Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 92, Issue 2, 1 April 1999, Pages 293–297, https://doi.org/10.1093/jee/92.2.293 Published: 01 April 1999
224 Surgeons should not Fear Performing Additional Urologic Procedures at the Time of Penile Prosthesis Implantation (2019)

Inflatable penile prosthesis (IPP) implantation represents an important treatment for erectile dysfunction (ED) that is considered the gold-standard when medical therapy is contraindicated, unsuccessful, or undesirable. Performing additional urological procedures at the time of IPP implantation is often avoided due to a perceived risk of increased complications, specifically infection. We aimed to explore the safety of performing adjunct procedures at the time of IPP implantation. Retrospective analysis of 736 patients who had an IPP insertion at a single center between May 2007 and March 2018. We identified and included all patients who had an adjunct procedure, defined as an additional surgical intervention at the time of primary or revision IPP implantation. We excluded patients who underwent any incontinence-related procedures such as insertion of an artificial sphincter or male sling, and patients who had a Peyronie’s disease repair. Patients were categorized as 1) urethral, 2) scrotal, 3) penile, or 4) inguinal surgery. Primary outcomes were infection, erosion, and 90-day complication rates.
Supplemental figures from CD20-TCB with Obinutuzumab Pretreatment as Next-Generation Treatment of Hematologic Malignancies (2023)

&lt;p&gt;Supplemental Figure 1. Assessment of the binding characteristics and cynomolgus monkey cross-reactivity of CD20-TCB. Supplemental Figure 2. Tumor cell lysis mediated by different CD20-targeting TCB antibodies. Supplemental Figure 3. T-cell and B-cell counts along with E:T ratio upon CD20-TCB treatment of primary bone marrow aspirates from patients with lymphoma and leukemia. Supplemental Figure 4. Quantification of interactions between T-cells and tumor cells from live imaging experiments and kinetic analysis of T-cell activation and exhaustion marker expression. Supplemental Figure 5. Secretion of cytokines, cytotoxic granules and T-cell proliferation upon tumor lysis. Supplemental Figure 6. Assessment of the cytokine-mediated endothelial cell activation. Supplemental Figure 7. Characterization of stem cell humanized mice (HSC-NSG) generated in house.&lt;/p&gt;
Disregarded Effect of Biological Fluids in siRNA Delivery: Human Ascites Fluid Severely Restricts Cellular Uptake of Nanoparticles (2015)

Small interfering RNA (siRNA) offers a great potential for the treatment of various diseases and disorders. Nevertheless, inefficient in vivo siRNA delivery hampers its translation into the clinic. While numerous successful in vitro siRNA delivery stories exist in reduced-protein conditions, most studies so far overlook the influence of the biological fluids present in the in vivo environment. In this study, we compared the transfection efficiency of liposomal formulations in Opti-MEM (low protein content, routinely used for in vitro screening) and human undiluted ascites fluid obtained from a peritoneal carcinomatosis patient (high protein content, representing the in vivo situation). In Opti-MEM, all formulations are biologically active. In ascites fluid, however, the biological activity of all lipoplexes is lost except for lipofectamine RNAiMAX. The drop in transfection efficiency was not correlated to the physicochemical properties of the nanoparticles, such as premature siRNA release and aggregation of the nanoparticles in the human ascites fluid. Remarkably, however, all of the formulations except for lipofectamine RNAiMAX lost their ability to be taken up by cells following incubation in ascites fluid. To take into account the possible effects of a protein corona formed around the nanoparticles, we recommend always using undiluted biological fluids for the in vitro optimization of nanosized siRNA formulations next to conventional screening in low-protein content media. This should tighten the gap between in vitro and in vivo performance of nanoparticles and ensure the optimal selection of nanoparticles for further in vivo studies.
Fourier transform infrared study of the polymer-dopant interaction in polyacetylene (1982)

Fourier transform infrared (FTIR) measurements of AsF5 doped (CH)x with dopant concentrations which vary over three orders of magnitude have been obtained in both the mid (4000–400 cm−1) and far (400–15 cm−1) infrared. The bandwidths of the strong bands characteristic of the doped polymer have been observed to be invariant with dopant concentration. However, the frequency positions of these new IR bands are found to be a sensitive function of the dopant level. In the far infrared, no evidence of the predicted soliton pinning mode was found for any of the dopant concentrations studied. The consequence of these results, in view of current theoretical models of the polymer-dopant interaction, is discussed.
Magnetic Polymers (2011)

Abstract Discovery of doped polyacetylenes and the following extensive investigations of π‐conjugated conducting polymers also evoked the attempt creating magnetic organic polymers. In the last two decades, theoretical and experimental studies on π‐conjugated organic molecules bearing plural unpaired electrons have elucidated a clear correlation between the molecular connectivity or substitution positions of the radical groups on the conjugated skeleton and spin multiplicity or spin quantum number (S) at a ground state. A stabilized high‐spin state (spin alignment, S &gt; 2/2) among the plural unpaired electrons was achieved based on an intramolecular and strong through‐bond spin‐exchange interaction through pi‐conjugation. Here we start with molecular structure‐S correlation of diradical model molecules as an example, and then extend the criteria for designing high‐spin organic polymers. The highest spin alignment (S) value of the polymers has been improved year by year through two main molecular design approaches: (i) π‐conjugated polymers bearing pendant radical groups, and (ii) cross‐conjugated, radical‐integrated polymers. Advantages and limitations of these two approaches are described, and the two‐dimensionally extended organic polyradical molecules (hyperbranched and/or cross‐conjugated network) are highlighted in this chapter. The molecular‐based, tunable magneto‐responsible polymer dots can lead to the potential application for the magnetic information storage, and the opto‐magnetic and electro‐magnetic properties of the polyradicals are promising field. The high‐spin organic polyradical molecules with chemical stability, flexibility, plasticity, and moldability will open a new field of magnetic organic materials.
Finding low-entropy sets and trees from binary data (2007)

The discovery of subsets with special properties from binary data hasbeen one of the key themes in pattern discovery. Pattern classes suchas frequent itemsets stress the co-occurrence of the value 1 in the data. While this choice makes sense in the context of sparse binary data, it disregards potentially interesting subsets of attributes that have some other type of dependency structure.
Incision Characteristics Associated With Six Laparoscopic Trocar-Cannula Systems (1999)

In Brief Objective Laparoscopic trocar-cannula systems of different design but similar internal diameter result in incisions of varying dimensions. Such variations might affect the incidence of incisional complications, such as dehiscence and hernia. We developed a system to measure associated fascial defects and then used the techniques to compare the defects resulting from different trocar-cannula systems. Methods This was a randomized, observer-blinded study. Six laparoscopic trocar-cannula systems of similar diameter (12 mm) were tested (two pyramidal, two blunt conical, and two cutting-dilating) using a white swine model. All systems were inserted into each of 12 subjects, with location designated by random allotment (total 72 insertions). The fascial defects were exposed and then directly measured for incisional length and area by an observer blinded to the system used. Means of each outcome variable (incisional length and area) were compared using factorial analysis of variance. Results The values for mean incisional areas were as follows: cutting-dilating 28.73 mm2 and 31.09 mm2, pyramidal 18.25 mm2 and 26.75 mm2, and blunt conical 10.00 mm2 and 12.33 mm2. Mean maximal incisional lengths were similar among all trocar-cannula systems. Conclusion Blunt conical trocar-cannula systems resulted in significantly smaller fascial defects compared with the widely used pyramidal and the two cutting-dilating trocar-cannula systems tested. These differences have potential clinical implications. For example, smaller fascial defects could reduce risk of incisional hernia and dehiscence. A system designed to evaluate the wounds of laparoscopic trocar-cannula systems found that those with blunt conical tips result in smaller fascial defects.
An improved process for the preparation of (S,S)-2, 8-diazabicyclo [4,3,0] nonane, a key intermediate of moxifloxacin hydrochloride (2011)

This contribution highlights the improved process for the preparation of high pure (S, S)-2, 8-diazabicyclo [4,3,0] nonane, a valuable intermediate of Moxifloxacin hydrochloride.Arobust process was described for resolution step using water as solvent and systematically studied the impact of factors such as water quantity, temperature and mole ratio of resolving agent that influence the resolution. The racemisation process of the undesired isomer using acid is provided. Purification conditions were optimized for the amide reduction step by screening the effect of solvent washings at different pH values. The final debenzylation conditions were altered to reduce the time cycle and reaction temperature whichminimize the impurity formation.
Single crystalline In–Ga–Zn oxide films grown from c-axis aligned crystalline materials and their transistor characteristics (2014)

Abstract In this study, we analyzed the crystallinity of c -axis aligned crystalline In–Ga–Zn oxide (CAAC-IGZO) and single crystalline (sc) IGZO films. CAAC-IGZO films were formed on (111)-oriented yttria-stabilized-zirconia substrates by magnetron sputtering using a target. Sc-IGZO films were obtained by annealing CAAC-IGZO films at 1200 °C. The proportion of Zn in the composition changed during growth of the films, and as a result, sc-InGaO 3 (ZnO) 3 films were obtained. By using CAAC-IGZO films as the starting material, sc-IGZO films were formed even without a ZnO layer. This is presumably because the CAAC-IGZO film originally exhibits c -axis orientation. In addition, the characteristics of transistors fabricated using sc-IGZO and CAAC-IGZO films were compared, and no significant difference in current drivability, i.e., field-effect mobility, was observed between the different transistors. In this sense, CAAC-IGZO films that require no high temperature annealing are favorable for industrialization.
A Simple Generalized Approach to Node Failure Recovery with Span-Protecting p-Cycles (2010)

This paper shows that, viewed in a generalized “two-hop” framework for node failure recovery, p-cycles actually have a very high inherent ability to restore paths transiting through a failed node. We also showed that with relatively little, if any, extra spare capacity, the principle is also amenable to explicit design of networks for 100% node and span failure protection with a single efficient set of p-cycles that support both functions. This is very different than the often-prevailing assumption that “ordinary” p-cycles offer no node protection, or only the same node-protection as a BLSR ring embodies. Indeed, the two-hop paradigm for recovery of affected paths transiting failed nodes could provide an attractive option for future network operators in that “ordinary” p-cycles are more localized, fast acting, and simple to plan and operate than any other option such as NEPCs, flow-protecting p-cycles or FIPPs.
Germanium-on-silicon waveguides for long-wave integrated photonics: ring resonance and thermo-optics (2021)

Germanium-on-silicon (GOS) represents the leading platform for foundry-based long-wave infrared photonic integrated circuits (LWIR PICs), due to its CMOS compatibility and absence of oxides. We describe ring resonance (Q-factors between 2×10<sup>3</sup> and 1×10<sup>4</sup>) and thermo-optic tunability in germanium-on-silicon waveguides throughout the long-wave-infrared. The ring resonances are characterized by Q-factors and couplings that agree with measurements of propagation loss (as low as 6 dB/cm) and simulations and are enabled by broadband edge coupling (12dB/facet over a 3 dB bandwidth of over 4 microns). We demonstrate the furthest into the infrared that ring resonators have been measured and show the potential of this platform for photonic integration and waveguide spectroscopy at wavelengths from 7 microns to beyond 11 microns.
<title>Transillumination of breast phantoms using diffuse photon-density waves</title> (1999)

Diffuse Photon Density Waves (DPDWs) characterise photon migration through diffusive media in the frequency-domain. Theoretically, we describe DPDWs propagation using the diffraction theory based on the diffusion approximation to the transport equation. Experimentally, we study the propagation of 100 MHz-modulated DPDWs through (optical)-breast-like phantoms. The great interest of probing these phantoms lies in the fact that they contain very small optical inhomogeneities, with a diameter of 5 mm only and with inhomogeneitj^ackground absorption and scattering contrasts of 1.1,1.5,2.0 and 4.0 respectively. We show that both most contrasted inhomogeneities (in absorption and scattering) can be distinguished, while the 1.5 contrasted one is visible only in scattering. This is consistent with the measured actual accuracy of our set-up which is 0.3% in amplitude and 0.15¡ in phase. Experimental results are compared to simulations, time-domain experimental results and X-ray measurements.
Abstract 1065: Growth factor-mediated resistance to BRAF/MEK inhibitors in BRAF mutant melanoma (2012)

Abstract BRAF and MEK inhibitors induce striking tumor regressions in BRAF V600E melanoma patients. However, relapse occurs in the majority of patients within several months. Reported resistance mechanisms include acquisition of NRAS mutations, PDGFR or IGF1R activation, Cot amplification, or truncated BRAF upregulation. We report here that hepatocyte growth factor (HGF), neuregulin-1 (NRG1), and fibroblast growth factor-2 (FGF2) cause robust resistance in vitro to BRAF or MEK inhibitors in BRAF mutant melanoma cell lines. NRAS mutant lines were similarly resistant to MEK inhibition in the presence of these growth factors. By contrast other mitogenic factors such as PDGF, EGF, NGF, BDNF, MSP, MDK, GRO, and IGF1 did not maintain cell viability or growth. HGF, NRG1 and FGF2 prevented growth arrest and cell death and in some cell lines maintained cells in progressive growth. In addition, HGF and NRG1 could prevent growth arrest after dual treatment with BRAF and MEK inhibitors. Western analysis revealed that HGF and NRG1 reactivated Erk signaling and activated S6RP and AKT phosphorylation. Combined pharmacological inhibition mTor signaling and Akt signaling was required to fully block growth factor-mediated proliferation. In addition, small molecule Met inhibitors and an anti-HGF antibody blocked HGF-mediated resistance, while lapatinib and an anti-NRG1 antibody blocked NRG1-mediated resistance. While combined Akt and mTor inhibition potently inhibited cell line growth independent of BRAF or MEK inhibition, lapatinib and Met inhibitors had minimal effect on growth, suggesting potential for less adverse events with receptor inhibitors. In vitro co-culture experiments revealed that primary cells present in normal skin can cause resistance, and we have identified growth factors produced by these cells that contribute to resistance. We are analyzing receptor activation (Met and Erbb3) and FGF2 expression in wildtype, NRAS, and BRAF mutant primary melanoma samples. In future experiments we plan to test clinical samples from patients treated with BRAF/MEK inhibitors, and we hypothesize that HGF, NRG1, and FGF2 signaling is elevated in patients with poor initial responses or relapse to BRAF or MEK inhibitors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1065. doi:1538-7445.AM2012-1065
New Woody and Ambery Notes from Cedarwood and Turpentine Oil (2005)

The development of a new product in the chemical industry is still driven by needs like technical properties, price/performance ratio, biodegradability, or product safety. However, in terms of improving more and more on ecological criteria, summarized under such catchphrases as sustainable development or green chemistry, another important aspect is to use renewable resources as starting materials. This is not significantly new in fragrance chemistry, and there are a lot of raw materials in the perfume oils that are derived from molecules of renewable resources. Two commonly used materials are: longifolene (from turpentine oil) and cedrene (from cedarwood oil). These compounds are very suitable for the synthesis of woody and ambery notes, and even though it seemed that all possibilities were exhausted, it is actually still feasible to discover new molecules with excellent olfactory properties such as Ambrocenide® (50a), which is available in three steps from α-cedrene. Some of these molecules will be treated in this review, both with respect to synthesis as well as structural and sensory aspects.
A qualitative exploration of patient experiences in pyoderma gangrenosum (2023)

Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that is associated with a decreased quality-of-life (QoL). There are no PG-specific patient-reported outcome measures. In this exploratory study, we use patient interviews to define QoL domains in PG that will inform future outcomes measures.
Analysis of small carbohydrates in several bioactive botanicals by gas chromatography with mass spectrometry and liquid chromatography with tandem mass spectrometry (2015)

Bioactive botanicals contain natural compounds with specific biological activity, such as antibacterial, antioxidant, immune stimulating, and taste improving. A full characterization of the chemical composition of these botanicals is frequently necessary. A study of small carbohydrates from the plant materials of 18 bioactive botanicals is further described. The study presents the identification of the carbohydrate using a gas chromatographic-mass spectrometric analysis that allows detection of molecules as large as maltotetraose, after changing them into trimethylsilyl derivatives. A number of carbohydrates in the plant (fructose, glucose, mannose, sucrose, maltose, xylose, sorbitol, and myo-, chiro-, and scyllo-inositols) were quantitated using a novel liquid chromatography with tandem mass spectrometric technique. Both techniques involved new method developments. The gas chromatography with mass spectrometric analysis involved derivatization and separation on a Rxi(®)-5Sil MS column with H2 as a carrier gas. The liquid chromatographic separation was obtained using a hydrophilic interaction type column, YMC-PAC Polyamine II. The tandem mass spectrometer used an electrospray ionization source in multiple reaction monitoring positive ion mode with the detection of the adducts of the carbohydrates with Cs(+) ions. The validated quantitative procedure showed excellent precision and accuracy allowing the analysis in a wide range of concentrations of the analytes.
Some Semlcarbazone Derivatives of Diorganotin(Iv) (1987)

Chemistry Department, Lucknow University, Luoknow-226 007 <em>Manuscript received 30 January 1986, accepted 10 June 1987</em> Some Semlcarbazone Derivatives of Diorganotin(Iv).
Real-time three dimensional transoesophageal echocardiography in imaging key anatomical structures of the left atrium: potential role during atrial fibrillation ablation (2012)

Atrial fibrillation (AF) is the most prevalent arrhythmia in western countries and it is estimated that its prevalence will increase further over the coming decades. AF affects 1% of the general population and up to 17% of patients aged >84 years.1 Until recently, pharmacological therapy has been the only treatment, but its efficacy is limited in terms of maintenance of sinus rhythm and control of symptoms.2 Over the last decade catheter based ablation of AF has proved to be more efficacious in comparison to medical treatment,3 especially in the paroxysmal form. Moreover, the catheter ablation strategy has evolved considerably, leading to significant improvements in efficacy and reductions in the procedural complication rate. Initially, linear lesions were performed in the atria mimicking the surgical Maze procedure4 which, however, resulted in limited success and significant complications. Haissaguerre et al 5 and Chen et al 6 found that AF is most commonly initiated by a premature beat from the orifices of the pulmonary veins (PVs). As a result, the procedure initially targeted elimination of foci inside the triggering vein (the earliest PV electrogram that initiates tachycardia), but this strategy was not effective enough to prevent recurrences which originated from the same or other veins. Therefore, electrical disconnection of all four PVs from the atrium became the proposed treatment option. The antral (also called circumferential) isolation of the veins is the approach that is most frequently used nowadays,7 and in many cases cures the disease.

As the atrium becomes more dilated and fibrotic, other structures in addition to PVs are increasingly being recognised as a possible source of AF initiation and/or are key in the perpetuation of AF. Typical locations of triggers and the micro-reentry circuit are one or more of the following atrial structures: left lateral ridge (LLR), left …
Nearfield Array Signal Processing Algorithms (2013)

This chapter gives an overview of farfield array signal processing. Conventional methods are first reviewed, and then more advanced imaging techniques, capable of high resolution, are introduced. Issues concerning how to reconcile beamforming performance and robustness against sensor noise and mismatch are discussed. How to choose array parameters is also presented.