gebhart/patrepeval huggingface dataset:
Infrequent ras Oncogene Point Mutations in Renal Cell Carcinoma (1990)

The role of ras oncogenes in the pathogenesis of renal cell carcinoma is unclear. We have previously shown that insertion of a mutated ras oncogene into cultured human proximal tubular cells, the normal counterpart of renal cell carcinomas, initiates a series of transformation events which results in cells possessing a renal cancer phenotype. These data suggested a role for mutated ras genes in the initiation and maintenance of this disease. Therefore, to assess the involvement of ras genes in renal carcinogenesis, 51 primary and metastatic renal carcinomas, including three oncocytomas, were analyzed for point mutations in codons 12, 13 and 61 of the Ha-ras, Ki-ras and N-ras proto-oncogenes using polymerase-catalyzed chain reaction methodology. A mutated Ha-ras gene was found in one renal cancer metastatic to lung for an overall incidence of 2%. These data indicate that ras oncogenes, activated by point mutations, do not play a major role in the initiation, maintenance or metastases of renal carcinomas.
Decentralized Safety for Aggressively Maneuvering Multi-Robot Interactions (2022)

This work provides a decentralized approach to safety by combining tools from control barrier functions (CBF) and nonlinear model predictive control (NMPC). It is shown how leveraging backup safety controllers allows for the robust implementation of CBF over the NMPC computation horizon, ensuring safety in nonlinear systems with actuation constraints. A leader-follower approach to control barrier functions (LF- CBF) enforcement will be introduced as a strategy to enable a robot leader, in a multi-robot interactions, to complete its task in minimum time, hence aggressively maneuvering. An algorithmic implementation of the proposed solution is provided and safety is verified via simulation.
Orforglipron ( LY3502970 ), a novel, oral non‐peptide glucagon‐like peptide‐1 receptor agonist: A Phase 1a, blinded, placebo‐controlled, randomized, single‐ and multiple‐ascending‐dose study in healthy participants (2023)

Orforglipron's long half-life (25-68 hours) allows once-daily oral dosing, without water and food restrictions. Orforglipron had a pharmacodynamic and safety profile similar to that of injectable GLP-1RAs, which supports continued clinical development.
The use of Multiple Variables to Predict Response to Endocrine Therapy in Carcinoma of the Prostate: A Preliminary Report (1984)

We are attempting to develop a method to predict hormonal response in patients with carcinoma of the prostate. We have measured multiple biochemical variables and determined Gleason grade in prostatic needle biopsies obtained from 16 patients immediately before castration or initiation of estrogen therapy. Biochemical variables included 6 enzymes (3 enzymes involved in androgen metabolism and 3 hydrolytic enzymes), androgen receptor content, and tissue testosterone and dihydrotestosterone content. The 16 patients were followed prospectively and the response of each patient to hormonal therapy was assessed clinically. Two groups of patients were identified: 1 group of 7 patients in which the mean duration of response was 7.7 plus or minus 1.5 months (plus or minus standard error) and in which all patients have relapsed and died of their disease, and a second group of 9 patients in which the mean duration of response was 18.6 plus or minus 1.6 months (plus or minus standard error) and in which 7 of the 9 patients (78 per cent) are still responding. The 2 groups were statistically different (p less than 0.001) in terms of duration of response. The 2 groups could not be distinguished by Gleason grade, single enzymatic activities or tissue androgen content. The mean value of nuclear salt extractable androgen receptor was statistically different between the 2 groups (p less than 0.05) but with considerable overlap of individual patients between the 2 groups. An index was developed based on multiple enzymatic activities, which separated the 2 response groups better than any single variable alone (p less than 0.02). When salt extractable nuclear androgen receptor was included in the numerator of this index the 2 groups were separated almost completely. This preliminary study suggests that the measurement of multiple biochemical variables may be useful in predicting hormonal response.
Reaction of Zirconium Fluoride Monohydrate and Ammonium Bifluoride: Its Effect on Fluoride Glass Preparation and Quality (1989)

The products obtained from the roomtemperature reaction of ammonium bifluoride and zirconium fluoride monohydrate are ammonium heptafluorozirconate ((NH 4 ) 3 ZrF 2 ), liquid water, and hydrogen fluoride. Ammonium bifluoride and zirconium fluoride monohydrate were reacted prior to glass batching, producing dry ammonium heptafluorozirconate which was used to prepare a high‐quality ZBLAN fluoride glass.
Synthesis of 2D Metal Chalcogenide Thin Films through the Process Involving Solution‐Phase Deposition (2018)

2D metal chalcogenide thin films have recently attracted considerable attention owing to their unique physicochemical properties and great potential in a variety of applications. Synthesis of large-area 2D metal chalcogenide thin films in controllable ways remains a key challenge in this research field. Recently, the solution-based synthesis of 2D metal chalcogenide thin films has emerged as an alternative approach to vacuum-based synthesis because it is relatively simple and easy to scale up for high-throughput production. In addition, solution-based thin films open new opportunities that cannot be achieved from vacuum-based thin films. Here, a comprehensive summary regarding the basic structures and properties of different types of 2D metal chalcogenides, the mechanistic details of the chemical reactions in the synthesis of the metal chalcogenide thin films, recent successes in the synthesis by different reaction approaches, and the applications and potential uses is provided. In the last perspective section, the technical challenges to be overcome and the future research directions in the solution-based synthesis of 2D metal chalcogenides are discussed.
IMS service-based bearer control (2006)

With the blurring of the lines between traditional telephony services and the growing number of Internet Protocol (IP)-based services available to customers of voice- and data-service providers, there is a growing need to provide a vertical interface between the service/session layer (where the service intelligence exists) and the transport layer (which provides the bearer path for service data traffic). The communication between the service/session layer and the bearer plane is referred to in standards organizations and in this paper as service-based bearer control (SBBC). The 3rd Generation Partnership Project (3GPP), the 3rd Generation Partnership Project 2 (3GPP2), the International Telecommunication Union-Telecommunication Standardization Sector (ITU-T) Focus Group on Next Generation Networks, and other standards organizations are discussing interfaces to provide SBBC functionality. This paper addresses the requirements of the SBBC interfaces and provides information about the capabilities they provide, but it does not reflect any particular set of standards, because the standards in this area are still very much under development. Rather, it presents various issues that are being discussed and that will influence the standards that are ultimately agreed upon.
CpG oligodeoxynucleotides stimulate IFN-γ-inducible protein-10 production in human B cells (2004)

Several classes of CpG oligodeoxynucleotides (ODNs) with different immune stimulatory profiles were recently identified: the A-, B- and C-classes. In this study, we investigated the CpG-dependent stimulation of IFN-gamma-inducible protein 10 (IP-10 or CXCL10) in different human immune cell types. CpG ODNs induced IP-10 in monocytes, pDCs and in B cells. Purified B cells as well as RPMI 8226 cells responded to CpG stimulation by IP-10 production. Treatment with exogenous IFN-alpha2b sensitized PBMCs, purified B cells as well as RPMI 8226 cells to respond more efficiently to stimulation with CpG ODNs by IP-10 production. IP-10 signaling could be directly stimulated via TLR9 in CpG-unresponsive HEK293 cells transfected with human TLR9 and an IP-10 reporter construct. Therefore, CpG-mediated IP-10 production is stimulated through IFN-alpha in cells that express the IFN-alpha receptor, a second pathway for IP-10 induction exists in TLR9-expressing B cells and pDCs where IP-10 is stimulated directly upon CpG-mediated TLR9 signaling. Our data provide a better understanding of the mechanisms through which CpG ODNs induce efficient Th1 responses.
Digital monitoring technologies could enhance tuberculosis medication adherence in Uganda: Mixed methods study (2019)

Digital adherence technologies may provide acceptable alternative approaches to monitoring TB medication, especially in settings where DOT is difficult to implement.
THE PHOTOPHYSICAL PROPERTIES OF PORPHYCENES: POTENTIAL PHOTODYNAMIC THERAPY AGENTS* (1986)

Abstract Porphycene and a tetra‐n‐propyl derivative remained unaltered on irradiation in toluene at room temperature. Quantum yields of fluorescence, S T intersystem crossing, and singlet molecular oxygen sensitization, as well as lifetimes of the singlet and triplet excited states were measured. In view of their structural relationship to porphyrin, their high absorption above 620 nm, their stability towards photooxidation, and their high quantum yields of fluorescence and singlet oxygen sensitization, these compounds qualify as potential agents for tumor marking and photodynamic therapy.
Diels-Alder reactions involving cross-conjugated dienones. Effects of substitution on reactivity (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiels-Alder reactions involving cross-conjugated dienones. Effects of substitution on reactivityDennis Liotta, Manohar Saindane, and Christopher BarnumCite this: J. Am. Chem. Soc. 1981, 103, 11, 3224–3226Publication Date (Print):June 1, 1981Publication History Published online1 May 2002Published inissue 1 June 1981https://pubs.acs.org/doi/10.1021/ja00401a056https://doi.org/10.1021/ja00401a056research-articleACS PublicationsRequest reuse permissionsArticle Views366Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Design and analysis of large-effective-area heterogeneous trench-assisted multi-core fiber (2012)

Based on the overlap integral of electromagnetic fields in neighboring cores, a calculating method is proposed for obtaining the coupling coefficient between two adjacent trench-assisted non-identical cores. And a kind of heterogeneous trench-assisted multi-core fiber (Hetero-TA-MCF) with 12 cores is proposed to achieve large effective area (A(eff)) and high density of cores. As bending radius becomes larger than 50 mm, the crosstalk value at 1550-nm wavelength of the Hetero-TA-MCF is about -42 dB after 100-km propagation and the A(eff) of this Hetero-TA-MCF can reach 100 µm(2).
Cooling to the recoil limit in an optical lattice (1996)

Summary form only given. A one-dimensional array of optical potential wells can be formed by interference of two counter-propagating linear and cross-polarized laser beams. This configuration is an example of an optical lattice, in which atoms are cooled to /spl mu/K temperatures and trapped in micron-sized potential wells. In this work Cs is cooled and trapped.
Supplementary Figure from Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma (2023)

Supplementary Figure from Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma
Potential affinity labels for the opiate receptor based on fentanyl and related compounds (1982)

Derivatives of fentanyl, 3-methylfentanyl, sufentanil, and lofentanil, possessing chemo- or photoaffinity functionalities, were synthesized as potential affinity reagents for the opiate receptor. Opiate receptor binding constants (IC50) were determined in competition experiments with [3H]naloxone and [3H]naltrexone. Affinity-labeling experiments were generally unsuccessful, although some irreversible attachment was achieved with alpha-diazoamide 17 and aryl azide 23.
Background-Free Near-Infrared Biphoton Emission from Single GaAs Nanowires (2023)

The generation of photon pairs from nanoscale structures with high rates is still a challenge for the integration of quantum devices, as it suffers from parasitic signals from the substrate. In this work, we report type-0 spontaneous parametric down-conversion at 1550 nm from individual bottom-up grown zinc-blende GaAs nanowires with lengths of up to 5 μm and diameters of up to 450 nm. The nanowires were deposited on a transparent ITO substrate, and we measured a background-free coincidence rate of 0.05 Hz in a Hanbury-Brown-Twiss setup. Taking into account transmission losses, the pump fluence, and the nanowire volume, we achieved a biphoton generation of 60 GHz/Wm, which is at least 3 times higher than that of previously reported single nonlinear micro- and nanostructures. We also studied the correlations between the second-harmonic generation and the spontaneous parametric down-conversion intensities with respect to the pump polarization and in different individual nanowires.
Decoupled Control of a Four-Leg Inverter via a New (2001)

Four-Leg (3-phase 4-wire) inverters are developed to power unbalanced/nonlinear three-phase loads. A unique 4 4 de- coupling transformation matrix is used that enables direct trans- formation between the four degree-of-freedom (DOF) leg-modu- lation space of the inverter and its corresponding 3-DOF output- voltage space. This is analogous to the well-known 3 - transformation developed for the three-leg inverter. Details of this new 4 4 Quad transform are provided, along with a de- piction of the voltage-vectors produced. Advanced synchronous- frame control techniques are applied with this 4-to-3 - transform to create a UPS-style inverter with sinewave output. Ex- perimental results for an 8.6 kVA prototype inverter are presented.
Digital controller chip set for isolated DC power supplies (2004)

This paper describes a digital controller chip set for high-frequency DC-DC power converters with galvanic isolation. The secondary-side controller includes an A/D converter and a transmitter that sends a digital error signal as serial data through an opto-coupler. The primary-side controller includes a serial-data receiver, a programmable digital PID regulator, and a high-resolution (10-bit) digital pulse-width modulator. The digital error signal transmission through the isolation boundary eliminates the problem of gain variation when the opto-coupler is used in linear mode. The chip set is tested as a replacement for a conventional analog current-mode controller in a 3.3 V, 20 A, 400 KHz DC power supply. Experimental results with the digital controller show improved dynamic responses compared to the responses obtained with the analog controller.
ChemInform Abstract: THE EFFECT OF SPUTTERED RUTHENIUM DIOXIDE OVERLAYERS ON THE PHOTOELECTROCHEMICAL BEHAVIOR OF CADMIUM SULFIDE ELECTRODES (1982)

Abstract Bezüglich einer Inhibition der Photokorrosion von CdS ( ;z.B. bei der Photoelektrolyse von Wasser) durch RuO 2 ‐Bedeckung wurden Verschiebungen des Flachband‐Potentials und des Photostrom‐Einsetzpötentials untersucht.
Long term discharge simulation through a geomorphological model (2013)

Flow duration curve estimation must be performed on the basis of continuous rainfall-runoff simulations. In ungauged basins, a under-parameterised model is needed to reduce the uncertainty of the results. In this paper a geomorphological model based on a width function (WFIUH) was used to simulate low flows in a meansized basin in Central Italy. The WFIUH model The aim of this work is to evaluate the behaviour of the WFIUH model for long term simulation and then to compare the standard curve number approach to the curve number method implemented in the WFIUH model. To predict the behaviour of catchments for a long term, to know the response of catchments in different seasons or in different years, it is necessary to improve the model and to identify a new method for calculating base-flow. To obtain these results, it is necessary to separate base-flow and stream-flow, simulate the two contributions and build a unique series of values that reproduces the answer of the basin to different rainfalls during the year to estimate the low flow during a dry period. The model can also be used in ungauged basins because a unique parameter is used.
Punctuating speech for information extraction (2008)

This paper studies the effect of automatic sentence boundary detection and comma prediction on entity and relation extraction in speech. We show that punctuating the machine generated transcript according to maximum F-measure of period and comma annotation results in suboptimal information extraction. Precisely, period and comma decision thresholds can be chosen in order to improve the entity value score and the relation value score by 4 % relative. Error analysis shows that preventing noun-phrase splitting by generating longer sentences and fewer commas can be harmful for IE performance. Indeed, it seems that missed punctuation allows syntactic parsers to merge noun-phrases and prevent the extraction of correct information.
USB‐Based 256‐Channel Electroencephalographic Data Acquisition System for Electrical Source Imaging of the Human Brain (2007)

Abstract A 256‐channel electroencephalographic data acquisition system is designed for electrical source imaging of the human brain. The system is microcontroller based, dc‐coupled, battery powered, and uses a universal serial bus for communication. An analog to digital converter of 24‐bit sigma‐delta technology with a sampling rate of 140 Hz and the number of effective bits in conversion is 18, corresponding to a dynamic range of 108 dB. Data is transferred via USB at the rate of 1 Mbyte/sec. The common mode rejection ratio of the system is measured as 102 dB. The performance tests and recorded experimental data show that the developed system can be used in conducting human brain source localization experiments.
New, Readily Available Organocatalysts for the Enantioselective Reduction of α-Imino- and β-Imino Esters (2011)

Novel metal-free, readily available chiral catalytic systems for the enantioselective reduction of keto imines are reported. Different β-imino esters were reduced by trichlorosilane in the presence of 10 mol% of a chiral Lewis base easily obtained in one step only from prolinol, in high yields and in up to 85% enantioselectivity; imines bearing an inexpensive and removable chiral auxiliary, were reduced with complete control of the absolute stereochemistry. The methodology was successfully extended to the stereoselective synthesis of α-amino esters.
Tarbela Dam—Problems Solved by Novel Concretes (1980)

While constructing the world's largest embankment dam, Tarbela in Pakistan, the designers and contractors faced unprecedented flow volumes and velocities, causing severe cavitation and erosion. The problems affected the tunnels, one of which collapsed, stilling basins, the flip buckets of both spillways, and the slops and floor of the two spillway plunge pools. The solutions, described in detail herein, involved application of special concretes. Record volumes of rollcrete were used to protect the high rock slopes, structures and foundations, and fiber concrete was used to repair stilling basins and spillways. Epoxy paints or coats were used early on to achieve smooth, resistant surface, but generally failed within days. They were ultimately replaced by conventional concrete.
<title>Hybrid microdosing system</title> (1998)

Based on an article in print this paper presents a hybrid assembled bi-directional micro dosing system for a water flow range of -40 (mu) l/min to 80 (mu) l/min. The system consists of a silicon micropump/valve chip (9 mm X 9 mm) and a silicon flow sensor (6 mm X 12 mm). The valve/pump can be driven by either a piezoelectric disk or an electrostatic actuator. Both, piezoelectric and electrostatic actuation for the pump/valve, the technology of each component and the hybrid assembling of the whole system are described. Results of transient numerical simulation of the pump and the mass flow sensor are presented and compared with experimental results. Descriptions of two different operational modes of the micro dosing system are given. The new pulse-width modulated control method for the actuator makes controlling the system easier. It allows an open-loop control of the pump rates without changing the driving frequency. All reported micropumps were driven by a square-wave signal which causes a relatively high noise level. In contrast to this, sawtooth and sinusoidal signals generate a smooth and quiet operation because of the small drag force on the fluid ports. Results of different driving methods are presented and compared.
Dynamic shape capture using multi-view photometric stereo (2009)

We describe a system for high-resolution capture of moving 3D geometry, beginning with dynamic normal maps from multiple views. The normal maps are captured using active shape-from-shading (photometric stereo), with a large lighting dome providing a series of novel spherical lighting configurations. To compensate for low-frequency deformation, we perform multi-view matching and thin-plate spline deformation on the initial surfaces obtained by integrating the normal maps. Next, the corrected meshes are merged into a single mesh using a volumetric method. The final output is a set of meshes, which were impossible to produce with previous methods. The meshes exhibit details on the order of a few millimeters, and represent the performance over human-size working volumes at a temporal resolution of 60Hz.
Longitudinal variation characteristics of stable isotope ratios of suspended particulate organic matter in the headwaters of the Qingjiang River, China (2021)

To determine the sources and characteristics of suspended particulate organic matter (SPOM), the spatial distribution of carbon and nitrogen and their isotopic values (δ 13 C and δ 15 N) were measured from upstreamto downstream ( i.e. site 1 to site 4) in the head waters of the Qingjiang River in central China. The mean annual SPOM δ 15 N and δ 13 C values varied between sites but exhibited a unimodal pattern. The mean annual δ 15 N increased from site 1 (2.5‰) to 3 (5.3‰), followed by a major decrease to 2.2‰ at site 4. Furthermore, the mean annual δ 13 C varied unimodally, being the most positiveat sites 1 (−21.6‰) and 4 (−22.8‰) followed by sites 2 (−24.5‰) and 3 (−26.4‰). In particular, the mean SPOM δ 15 N and δ 13 C in the tailwaters from a domestic wastewater treatment plant, which was located approximately 0.3 km upstream of site 4, were 2.2‰ and −25.6‰, respectively. The SPOM C/N values from stream water at site 4 (8.5 ± 1.5) and tailwater (6.2 ± 0.9) were similar. Collectively, the results suggested that wastewater treatment plant tailwater influenced the stable isotope values of SPOM in the stream and affected the variation trendfrom upstream to downstream.