gebhart/patrepeval huggingface dataset:
Aluminum ions enhance polyimide adhesive (1981)

Adding complexed aluminum ions raises useful temperature of polyimide adhesive without embrittling it or reducing long term stability. Adhesives may be applied to prepared substrate surface without supports. Possible substrates are metal, composite, or polymeric film. Adhesive is excellent where bond flexibility is required.
Induction of Autoimmune Valvular Heart Disease by Recombinant Streptococcal M Protein (2001)

Rheumatic heart disease is an autoimmune sequela of group A streptococcal infection. Previous studies have established that streptococcal M protein is structurally and immunologically similar to cardiac myosin, a well-known mediator of inflammatory heart disease. In this study, we investigated the hypothesis that streptococcal M protein could produce inflammatory valvular heart lesions similar to those seen in rheumatic fever (RF). Fifty percent (3 of 6) of Lewis rats immunized with recombinant type 6 streptococcal M protein (rM6) developed valvulitis as well as focal lesions of myocarditis. Valvular lesions initiated at the valve surface endothelium spread into the valve. Anitschkow cells and verruca-like lesions were present. T cells from rM6-immunized rats proliferated in the presence of purified cardiac myosin, but not skeletal myosin. A T-cell line produced from rM6-treated rats proliferated in the presence of cardiac myosin and rM6 protein. The study demonstrates that the Lewis rat is a model of valvular heart disease and that streptococcal M protein can induce an autoimmune cell-mediated immune attack on the heart valve in an animal model. The data support the hypothesis that a bacterial antigen can break immune tolerance in vivo, an important concept in autoimmunity.
Links with the Past (1899)

Journal Article Links with the Past Get access Henry Taylor Henry Taylor 1Birkiands, Southport Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s9-IV, Issue 94, 14 October 1899, Page 319, https://doi.org/10.1093/nq/s9-IV.94.319b Published: 14 October 1899
Two Regions of Simian Virus 40 T Antigen Determine Cooperativity of Double-Hexamer Assembly on the Viral Origin of DNA Replication and Promote Hexamer Interactions during Bidirectional Origin DNA Unwinding (1999)

Phosphorylation of simian virus 40 large tumor (T) antigen on threonine 124 is essential for viral DNA replication. A mutant T antigen (T124A), in which this threonine was replaced by alanine, has helicase activity, assembles double hexamers on viral-origin DNA, and locally distorts the origin DNA structure, but it cannot catalyze origin DNA unwinding. A class of T-antigen mutants with single-amino-acid substitutions in the DNA binding domain (class 4) has remarkably similar properties, although these proteins are phosphorylated on threonine 124, as we show here. By comparing the DNA binding properties of the T124A and class 4 mutant proteins with those of the wild type, we demonstrate that mutant double hexamers bind to viral origin DNA with reduced cooperativity. We report that T124A T-antigen subunits impair the ability of double hexamers containing the wild-type protein to unwind viral origin DNA, suggesting that interactions between hexamers are also required for unwinding. Moreover, the T124A and class 4 mutant T antigens display dominant-negative inhibition of the viral DNA replication activity of the wild-type protein. We propose that interactions between hexamers, mediated through the DNA binding domain and the N-terminal phosphorylated region of T antigen, play a role in double-hexamer assembly and origin DNA unwinding. We speculate that one surface of the DNA binding domain in each subunit of one hexamer may form a docking site that can interact with each subunit in the other hexamer, either directly with the N-terminal phosphorylated region or with another region that is regulated by phosphorylation.
A new standard activity in IEEE 802.22 wireless regional area networks: Enhancement for broadband services and monitoring applications in TV whitespace (2012)

This paper presents the recent update on IEEE 802.22 wireless regional area network (WRAN) working group activities, especially IEEE 802.22b task group (IEEE 802.22b) for enhancement for broadband services and monitoring applications in TV whitespace (TVWS). As an action to extend and enhance IEEE 802.22 applications, a new IEEE 802.22b task group has been formed and approved by the IEEE 802 executive committee. The objective of IEEE 802.22b specifies new amendment of IEEE 802.22-2011 to include low complexity monitoring applications, as well as enhance the currently available broadband services. In this paper, we briefly introduce use cases and technical topics, as well as future direction on system design, system classes such as introduction of low complexity devices, possible access methods, throughput improvement options etc.
Performance of cochlear implant recipients with GJB2‐related deafness (2002)

Congenital profound hearing loss affects 0.05-0.1% of children and has many causes, some of which are associated with cognitive delay. For prelingually-deafened cochlear implant recipients, the etiology of deafness is usually unknown. Mutations in GJB2 have been established as the most common cause of heritable deafness in the United States. In this report, we identify cochlear implant recipients with GJB2-related deafness and examine the performance of these individuals. Cochlear implant recipients received a battery of perceptive, cognitive, and reading tests. Neither subjects nor examiners knew the etiology of deafness in these individuals. The implant recipients were then examined for mutations in GJB2 using an allele-specific polymerase chain reaction assay, single-strand conformation polymorphism analysis, and direct sequencing. GJB2 mutations were the leading cause of congenital deafness among the cochlear implant recipients screened. Cochlear implant recipients with GJB2-related deafness read within one standard deviation of hearing controls better than other congenitally deaf cochlear implant recipients and non-cochlear implant recipients. Individuals with congenital deafness should be offered GJB2 screening. Positive results establish an etiologic diagnosis and provide prognostic, genetic, and therapeutic information. Effective rehabilitation for profoundly deaf individuals with GJB2-related deafness is possible through cochlear implantation.
Quad-emissive display for multi-spectral sensor analyses (2009)

The Quad-Emissive Display (QED) is a device that is designed to provide suitable emissive energy in four spectral bands to permit the simultaneous evaluation of sensors with different spectral sensitivities. A changeable target pattern, such as a Landolt C, a tumbling "E", a triangle or a bar pattern, is fabricated as a stencil (cutout) that is viewed against a second, black surface located several centimeters behind the stencil and thermally isolated from the stencil target. The sensor spectral bands of interest are visible (0.4 to 0.7 microns), near infrared (0.7 to 1.0 microns), short wave infrared (1.0 to 3.0 microns) and the long wave infrared (8.0 to 14.0 microns). This paper presents the details of the structure of the QED and preliminary results on the types of sensor/display resolution measurements and psychophysical studies that can be accomplished using the QED.
Cavitation detection during and following HIFU exposure in vitro (2004)

Is the existence of a sustained hyperechogenic region on B-scan images following HIFU treatment a necessary and sufficient condition for cavitation to have occurred during HIFU exposure? Three means of cavitation monitoring were used synchronously, before, during, and after continuous-wave HIFU exposure of an agar-graphite tissue phantom. A 1.1-MHz HIFU transducer was confocally aligned with a 15-MHz passive cavitation detection (PCD) transducer and a 5-MHz scan head. The HIFU pressure amplitude was increased in steps of 0.26 MPa every 5 s. A peak detector recorded the peak PCD signal level and a dynamic signal analyzer monitored broadband noise emissions (5–10 MHz). The sudden onset of a PCD output signal occurred at a peak-negative focal pressure of 1.25 MPa; no post-HIFU hyperechogenic region was visible on the B-scan images. A hyperechogenic region did eventually appear, but only for focal pressures in excess of 1.8 MPa. Inertial cavitation can therefore occur during HIFU exposure in the absence of a post-HIFU hyperechogenic region. The focal pressure for which such a region is observed can be as much as 50% higher than the threshold pressure for inertial cavitation inception. [Work supported by the ASA and the NSF Center for Subsurface Sensing and Imaging Systems.]
Well Control When Drilling With a Partly-Evacuated Marine Drilling Riser (2011)

Abstract The Low Riser Return System (LRRS) is a method used for managing wellbore pressure during offshore drilling operations by adjusting the mud level in the marine riser by returning mud and cuttings to surface via a subsea pump in a separate conduit. It is a single mud gradient, open MPD system particularly designed for subsea drilling. The LRRS can be used in two application modes. The first has a full riser during static conditions using conventional mud weights and the capability to lower the fluid level to compensate for the ECD effect during circulation and drilling as needed. With this technique, conventional well control procedures are used. The second technique involves using higher than conventional mud weights and lower fluid levels for both static and dynamic (circulating) operations. With this technique, modified well control procedures must be used. Both of these methods improve safety margins, allow for better pressure control, and increase efficiency for most well operations. This paper focuses on the well control issues of drilling with a partially evacuated marine drilling riser. Two cases using data from deepwater US GoM wells illustrate how the LRRS gradient fits well inside the drilling window. Kick margins and kick detection are improved compared to conventional drilling operations, and riser margin can be achieved even for relatively deep water, which allows for safer disconnections. Improved cementing by compensating for density and ECD effects is another important result of applying this system. We conclude that this technology can greatly improve safety in drilling of deepwater exploration and production wells as well as for infill drilling in depleted fields; enabling safe access to more reserves and improving recovery.
ChemInform Abstract: Superconductivity at 43 K in an Iron‐Based Layered Compound LaO1‐xFxFeAs. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Phase I trial of cancer vaccine with multiple peptides derived from novel onco-antigen and anti-angiogenic antigens for patients with advanced non-small cell lung cancer (NSCLC). (2012)

e13015 Background: Two phase I clinical trials were conducted on patients with advanced or recurrent NSCLC to evaluate the safety, immunogenicity and clinical response of a multiple peptide vaccine that incorporates four epitope peptides. This vaccine is comprised of novel HLA-A24-restricted oncoantigens, including two of the following three peptides; up-regulated lung cancer 10 (URLC10), TTK protein kinase (TTK) and cell division associated 1 (CDCA1), in addition to peptides derived from vascular endothelial growth factor receptor 1 (VEGFR1) and 2 (VEGFR2). Methods: Peptides derived from URLC10, TTK, VEGFR1 and VEGFR2 were tested in Trial 1, while peptides derived from URLC10, CDCA1, VEGFR1 and VEGFR2 were tested in Trial 2. Fifteen HLA-24-positive patients with NSCLC who had not responded to standard therapy were enrolled in this classic 3 patient per dose per cohort phase I trial, designed with varying dosages (Trial 1; 0.5mg, 1mg and 3mg, Trial 2; 1mg, 3mg). Vaccines were administered weekly by subcutaneous injection into patients’ axillary region with Montanide ISA-51 incomplete Freund’s adjuvant until progressive disease occurred and/or patients refused further treatment. Immunological responses were evaluated by INF-gamma ELiSPOT assays. Results: Vaccinations were well-tolerated withno severe treatment-associated adverse events. Specific T cell responses were induced in all patients against at least one epitope peptide. However, weak immunological responses were found in the 0.5mg group compared with the 1mg and 3mg groups in Trial 1, therefore the 0.5mg group was excluded in Trial 2. In terms of clinical responses, no complete and partial responses were found, however 9 of 15 patients (60 %) were categorized with stable disease. The median overall survival time was 13.2 months, while 1- and 2-year survival rates were 52.5% and 32.8% respectively. Conclusions: Multiple peptide vaccination therapy using four novel peptides was safe, and could possibly be effective in extending the patients’ survival. These encouraging immunological and clinical responses could provide a case for further stages of clinical trials.
On a Discrete Variational Problem Involving Interacting Particles (1999)

We consider the minimization problem $$ \quad \min {\cal{F}} ({\bf{z}}) \equiv -\sum_{k < j} \log |z_k-z_j|, \qquad k, j = 1, 2, \dots, N, $$ for ${\bf{z}} = (z_1, z_2, \dots, z_N) \in \mathbb{C}^N$ satisfying $\sum_{k=1}^{N} |z_k|^2=1$ and $z_k \ne z_j$ for $1 \le k < j \le N.$ This problem arises in different contexts in several physical models such as incompressible Euler equations and the Ginzburg--Landau model in superconductivity. We study the stability properties of some symmetric critical points such as regular polygons and configurations that consist of a regular polygon plus the origin. We also establish the existence of an infinite number of critical points enjoying different kinds of symmetry. We show that when the number of particles, N, exceeds a critical value, the global minimizer cannot be a regular polygon ($N\ge6$), and if $N \ge 11$ it cannot be a star configuration (i.e., an N-1 sides regular polygon plus the origin).
Phylogenetic Relationships of Monascus Species Inferred from the ITS and the Partial β-tubulin Gene (2004)

ITS and partial β-tubulin genes of 17 ATCC reference strains of Monaccus species were PCR amplified and sequenced. Monascus pilosus and M. ruber could not be differentiated with these sequences, suggesting a synonymy. In maximum parsimony analyses on both data sets, M. ruber, M. pilosus, M. purpureus, and M. sanguineus were placed into the same clade. ITS sequence alignment revealed a number of gaps in ITS1 and ITS2 of M. pallens, M. lunisporas, and M. eremophilus compared to M. purpureus, M. ruber, and M. pilosus. Accordingly, analyses with the ITS sequences placed these species into clades, incongruent with the analyses using the partial β-tubulin genes and the previous results with the partial large subunit rRNA genes. The phylogenetic relationship derived from the partial β-tubulin genes was similar to those postulated by the 5'-partial LSU rRNA genes. This finding strongly suggests that evolutionary or phylogenetic classification with ITS sequence information should be performed with caution. in the phylogenetic trees with the ITS sequences, M. lunisporas was distantly associated with Aspergillus ustus; M. pallens was placed in a clade that shares a common node with A. versicolor; and M. eremophilus was placed on a branch separate from the M. purpureus, M. ruber and M. pilosus group while M. pallens and M. lunisporas were placed into the related clades sharing a common node in the tree derived from the partial β-tubulin gene. Each of the phylogenetic analyses with the partial β-tubulin genes, the ITS, or the 5-end of the LSU rRNA, as previously carried out, placed M. eremophilus into a different lineage. Molecular analyses with these molecular targets generated three different topologies for M. eremophilus, indicating a unique and unpredictable genetic combination for this species. It might reflect extreme environmental stress on this species and subsequent genetic changes.
Engineering NK Cells Modified With an EGFRvIII-specific Chimeric Antigen Receptor to Overexpress CXCR4 Improves Immunotherapy of CXCL12/SDF-1α-secreting Glioblastoma (2015)

Natural killer (NK) cells are promising effector cells for adjuvant immunotherapy of cancer. So far, several preclinical studies have shown the feasibility of gene-engineered NK cells, which upon expression of chimeric antigen receptors (CARs) are redirected to otherwise NK cell-resistant tumors. Yet, we reasoned that the efficiency of an immunotherapy using CAR-modified NK cells critically relies on efficient migration to the tumor site and might be improved by the engraftment of a receptor specific for a chemokine released by the tumor. On the basis of the DNAX-activation protein 12 (DAP12), a signaling adapter molecule involved in signal transduction of activating NK cell receptors, we constructed an epidermal growth factor variant III (EGFRvIII)-CAR, designated MR1.1-DAP12 which confers specific cytotoxicity of NK cell towards EGFRvIII glioblastoma cells in vitro and to established subcutaneous U87-MG tumor xenografts. So far, infusion of NK cells with expression of MR1.1-DAP12 caused a moderate but significantly delayed tumor growth and increased median survival time when compared with NK cells transduced with an ITAM-defective CAR. Notably, the further genetic engineering of these EGFRvIII-specific NK cells with the chemokine receptor CXCR4 conferred a specific chemotaxis to CXCL12/SDF-1α secreting U87-MG glioblastoma cells. Moreover, the administration of such NK cells resulted in complete tumor remission in a number of mice and a significantly increased survival when compared with the treatment of xenografts with NK cells expressing only the EGFRvIII-specific CAR or mock control. We conclude that chemokine receptor-engineered NK cells with concomitant expression of a tumor-specific CAR are a promising tool to improve adoptive tumor immunotherapy.
Comparative Study and Experimental Validation of Phase-Sensitive-Detection Techniques for Sensor Lock-in Amplifiers (2023)

Often in a sensor system, the signal of interest from the sensor is smaller than the signal due to noise. Lock-in amplifiers have been used to efficiently differentiate the signal of interest from noise and unwanted signals in such scenarios. Phase-sensitive detection (PSD) is an important building block of a lock-in amplifier. Analog switches and multipliers are the two most widely used techniques for the phase-sensitive detection of sensor lock-in amplifiers. Each technique has some distinct advantages and disadvantages as well. In this paper, we have studied and experimentally validated the performance of these two techniques for the PSD in sensor lock-in amplifiers. The techniques are validated with a sine wave, square-wave excitation, and modulation signals. Further, the methods are validated by integrating with a lock-in amplifier. Finally, the performance analysis of these two techniques is tabulated based on the obtained experimental results. The results show that the multiplier-based system shows an error of less than 1%, whereas the square-wave excitation system shows an error as high as 5%.
European Research towards Future Wireless Communications (2005)

This paper presents an overview of four on-going European research projects in the field of mobile and wireless communications leading to the next generations of wireless communications. The projects started in 2004. They investigate requirements and definition of access technology, network architecture, antennas and propagation, security, services, applications and socio-economic impact.
Low-Overhead Joint Beam-Selection and Random-Access Schemes for Massive Internet-of-Things with Non-Uniform Channel and Load (2020)

We study low-overhead uplink multi-access algorithms for massive Internet-of-Things (IoT) that can exploit the MIMO performance gain. Although MIMO improves system capacity, it usually requires high overhead due to Channel State Information (CSI) feedback, which is unsuitable for IoT. Recently, a Pseudo-Random Beam-Forming (PRBF) scheme was proposed to exploit the MIMO performance gain for uplink IoT access with uniform channel and load, without collecting CSI at the BS. For non-uniform channel and load, new adaptive beamselection and random-access algorithms are needed to efficiently utilize the system capacity with low overhead. Most existing algorithms for a related multi-channel scheduling problem require each node to at least know some information of the queue length of all contending nodes. In contrast, we propose a new Low-overhead Multi-Channel Joint Channel-Assignment and Random-Access (L-MC-JCARA) algorithm that reduces the overhead to be independent of the number of interfering nodes. A key novelty is to let the BS estimate the total backlog in each contention group by only observing the random-access events, so that no queue-length feedback is needed from IoT devices. We prove that L-MC-JCARA can achieve at least `0.24`` of the capacity region of the optimal centralized scheduler for the corresponding multi-channel system.
Smart Radio Environments (2021)

This Roadmap takes the reader on a journey through the research in electromagnetic wave propagation control via reconfigurable intelligent surfaces. Meta-surface modelling and design methods are reviewed along with physical realisation techniques. Several wireless applications are discussed, including beam-forming, focusing, imaging, localisation, and sensing, some rooted in novel architectures for future mobile communications networks towards 6G.
Optical bistability in photonic crystal systems (2003)

Using an analytical theory and detailed computational experiments, we predict surprising optical bistability behavior in various photonic crystal systems.
Toward context-aware computing: experiences and lessons (2001)

To minimize distractions, a pervasive-computing environment must be context-aware. The authors define an activity-attention framework for context-aware computing, discuss the spatial and temporal aspects of applications they developed, and introduce a pervasive-computing architecture.
ICONE11-36466 STUDY OF THE EFFECT OF AXIAL NEUTRON SOURCE DISTRIBUTION ON THE DETECTOR SIGNAL FOR A MODIFIED NEUTRON SOURCE MULTIPLICATION METHOD (2003)

The authors have been studying on the applicability of a digital reactivity meter fbr monitoring the subcriticality in a system of homogeneous reactivity addition based on both analytical
D’une innovation en réponse à un besoin interne à la conquête d’un marché en émergence (2018)

Michelin s’est initié très tôt à la fabrication additive métallique et a ainsi pris une avance déterminante sur ses concurrents. Au travers d’AddUp, société créée avec Fives, le Groupe entend investir ce marché au développement rapide et aux défis nombreux.
Squalene versus cholesterol: Which is the best nanocarrier for the delivery to cells of the anticancer drug gemcitabine? (2018)

It has been previously shown that the linkage of the anticancer drug gemcitabine (Gem) to the squalene (SQ), a natural lipid precursor of the cholesterol biosynthesis, allowed the resulting bioconjugates to spontaneously self-assemble as nanoparticles (NPs) with improved pharmacological activity. We show here that when the squalene moiety was replaced by the cholesterol and the conjugation performed through a carbamate linker, although rather stable nanoparticles were obtained, the in vitro anticancer activity in the human breast cancer cell line MDA-MB-231 was completely abolished. This was attributed to reduced enzymatic accessibility toward the carbamate linker, which may hamper the gemcitabine release. A lower propensity of incorporation into the plasma cell membrane, which was revealed by molecular simulations, may also play a role in lower activity of cholesterol derivative.