gebhart/patrepeval huggingface dataset:
Primary Frequency Control Provision by Distributed Energy Resources in Active Distribution Networks (2021)

The rising share of renewable energy sources in electricity grids has strongly impacted the operation of both transmission and distribution systems. With the decommissioning of synchronous generators, the transmission systems are becoming less resilient to disturbances, while the proliferation of Distributed Energy Resources (DERs) in distribution networks has opened new possibilities for distribution system operators, enabling them to support the transmission system by offering ancillary services. This paper proposes a centralized controller for provision of Primary Frequency Control (PFC) by aggregations of DERs in active distribution networks. The controller aims to find optimal setpoint adjustments for DERs to regulate the power flow at the transmission system interconnection according to PFC provision requirements. At the heart of the proposed method lies a multi-period optimal power flow formulation, which accommodates different timescale dynamics of the employed DERs, as well as the network constraints. The active power required for provision of PFC is calculated using a recently developed frequency prediction model. Simulation results obtained from a dynamic model of the IEEE 33-bus system demonstrate the effectiveness of the proposed scheme.
Lupus erythematosus‐like features in patients with cutaneous T‐cell lymphoma (1998)

Our report identifies four patients with CTCL who developed LE-like features during the course of their disease. Although the etiology of CTCL and SLE has not been well established, each has been linked to retroviruses. Evidence of antibodies to retroviral proteins was identified in each of our patients by Western blot analysis. Although the clinical and laboratory findings in these cases do not resolve the etiologic role of retroviruses in CTCL or SLE, they suggest that retroviruses may have a role in the pathogenesis of the clinical phenomenon reported in these four patients.
Study on 4K-GM Refrigerator. Effects of Specific Heat of Regenerator Material on Refrigeration Capacity. (2000)

In this paper we describe the analysis of the effects of the specific heat of a regenerator material on the refrigeration capacity of a 4K-GM (Gifford-McMahon) refrigerator. The findings revealed by the analysis are given below. When the specific heat of the regenerator material is changed from 1.5 J/(K·cm3) to 0.01 J/(K·cm3), the no-load temperature is changed from 2.11 K to 26.9 K. The lowest temperature that can be theoretically attained in this refrigerator is the temperature around the λ point of helium. It is sufficient for the regenerator material to provide a specific heat of 0.8 J/(K·cm3). The refrigeration capacity is found to be superior over a wider temperature range when the specific heat distribution is uniform than when it has a peak. When different kinds of regenerator materials are stacked, the material stacked at the cold part of the regenerator may have a low specific heat at high temperatures, but the material stacked at the hot part of the regenerator should have a high specific heat at low temperatures.
Centromere and Kinetochore: Essential Components for Chromosome Segregation (2017)

In most metazoans, multiple microtubules bind to each kinetochore, with an exception of certain budding yeasts where only a single microtubule appears to be associated with each kinetochore. Apart from these general features of mitosis, organism-specific variations also exist. During closed mitosis, the nuclear envelope (NE) remains intact throughout the cell cycle, the spindle forms within the nucleus followed by chromosomal segregation and subsequent nuclear fission. This chapter discusses players and the process of chromosome segregation via mitotic cell cycle in fungal, animal, and plant kingdoms. It also discusses the growing knowledge of the same in protozoa as well. The fungal kinetochores are well studied and formed by more than 80 known proteins assembled on the centromere DNA. Molecular details of the proteins and their organization in a plant kinetochore are less explored compared to other eukaryotes.
A phase Ib study for MNRP1685A (anti-NRP1) administered intravenously with bevacizumab with or without paclitaxel to patients with advanced solid tumors. (2011)

3050^ Background: Neuropilin-1 (NRP1) is involved in remodeling and maturation of blood vessels. MNRP1685A is a human monoclonal antibody that blocks binding of ligands, including VEGF, VEGF-B and PlGF, to NRP1 thereby maintaining vessel immaturity and VEGF-dependency. This study sought to determine whether MNRP1685A can be safely combined with bevacizumab with or without paclitaxel. Methods: Patients received escalating doses of MNRP1685A with 15 mg/kg bevacizumab (every 3 weeks) in Arm A, or with 10 mg/kg bevacizumab (every two weeks) and 90 mg/m2 paclitaxel (weekly, 3 of 4 weeks) in Arm B. Objectives were to determine safety, pharmacokinetics (PK), pharmacodynamics (PD), and the maximum tolerated dose of MNRP1685A in both arms. Results: 14 patients were enrolled into dose-escalation cohorts (3+3 design) of 7.5, 15, 24 and 36 mg/kg in Arm A, and 10 patients into cohorts of 12 and 16 mg/kg in Arm B. As in phase Ia, grade 1 or 2 acute infusion reactions (AIRs, mainly rash and pruritus, premedication included dexamethasone) and transient platelet reductions within 2-8 days following MNRP1685A infusion were observed. Treatment-related grade 3-5 adverse events (AEs; cut-off date 11/23/10) included 1 sudden death, unknown etiology, at Day 7 in Arm A (36 mg/kg), neutropenia (n=4, all Arm B), proteinuria (n=3), thrombocytopenia (n=2), hypertension (n=2), and one each of fatigue, keratorhexis, and peripheral edema. AEs occurring in ≥25% included AIRs (67%), neutropenia (60%, Arm B), hypertension (29%), fatigue (29%), epistaxis, nausea and proteinuria (25% each). 5 of 5 patients treated beyond 5 cycles developed grade ≥2 proteinuria. MNRP1685A PK was similar to phase Ia, but increases in PD biomarker placental growth factor were higher and sustained longer. Conclusions: The safety profile of MNRP1685A when combined with bevacizumab with or without paclitaxel was evaluated in this Phase Ib study. AIRs were frequent but tolerable with premedication. Platelet reductions were frequent, transient and recoverable. A higher than expected rate of clinically significant proteinuria, resulting in hold or discontinuation of drugs, was observed.
Chemical Synthesis of an Erythropoietin Glycoform Containing a Complex‐type Disialyloligosaccharide (2012)

Neu und verbessert: Neue Reaktionsbedingungen für die tert-Boc-basierte Festphasenpeptidsynthese machen säurelabile Sialyloligosaccharylpeptid-α-thioester zugänglich. Als Beleg wurde eine 166 Aminosäuren umfassende Erythropoietin-Sialyloligosaccharyl-Glycoform (siehe Bild) synthetisiert.
HbA1c Reduction in Diabetic Older Blacks and Hispanics: A Study on Mobile Physical Activity Tracking (2023)

ABSTRACT Introduction/Purpose Diabetes is a leading cause of morbidity and mortality and is more prevalent in Blacks and Hispanics. This study aims to examine if different physical activity (PA) intensities reduced hemoglobin A1c (HbA1c) in Blacks and Hispanics with type 2 diabetes mellitus (DM2). Methods This pilot study used a one-sample pre- and postintervention design, including four in-person visits during a period of 3 months from January 2018 to December 2020 in Black or Hispanic populations with DM2 in the Greater Hartford, Connecticut, area. At each in-person visit HbA1c; specific, measurable, achievable, realistic, and time-bound goals; and daily PA (categorized into high-, moderate-, or low-intensity levels by a Fitbit ® Charge 2) were obtained. Change scores for minutes engaged in each PA level and HbA1c values were created between visits. A linear mixed model was used to analyze these relationships over time. Results Among 17 completed participants, mean age was 56 yr, 11 were Black, 6 were Hispanic, 13 were female, and 4 were male. At baseline, mean body mass index was 34.8 kg·m −2 and mean systolic/diastolic blood pressure was 135/81 mm Hg. From 70.2 mmol·mol −1 at baseline, HbA1c decreased to 66.3 after 4 wk, 66.0 after 8 wk, and 63.5 by 12 wk (9.5% reduction, P &lt; 0.05). Average daily PA time increased over 3 months from 15.8 to 20.3 ( P = 0.04) to 20.8 ( P = 0.02) minutes for moderate-intensity PA ( P = 0.05), and from 12.1 to 13.6 ( P = 0.08) to 15.2 ( P = 0.01) minutes for high-intensity PA. PA increases were significantly associated with an overall 0.58% reduction of HbA1c ( P = 0.04). Conclusion Guided by carefully selected, evidenced-based behavioral change strategies, this study found that increases of ~7 min of moderate- or high-intensity daily PA were associated with ~10% decrease in HbA1c in Blacks and Hispanics with DM2. This is consistent with the current consensus statement from the American College of Sports Medicine.
Analysis of structural forms of lightweight hole for heavy caliber mirror (2000)

Aiming at the main mirror of certain space camera, the paper analyzes the effect of several structural forms of lightweight hole on dynamic and static rigidity of mirror itself. According to processing method of optical instruments, CAD technology is adopted to set up FEM model of mirror body and then the best structural form of lightweight hole in mirror is optimized.[WT5HZ]
Empty-loadable MHC class I tetramers for efficient detection of antigen-specific T cells (2020)

Abstract The peptide-dependent stability of MHC class I molecules poses a substantial challenge for their use for peptide-MHC multimer-based approaches to comprehensively analyze T cell immunity. We demonstrate here the generation, analysis, and use of empty-loadable (peptide-free) MHC class I tetramers made from disulfide-stabilized MHC molecules. A disulfide bond links the α1 and α2 helices of MHC class I molecule at the extreme end of the F pocket. It allows in vitro folding of recombinant A2 with a dipeptide and subsequent removal of the dipeptide to yield stable peptide-receptive MHC monomers. Empty-loadable tetramers prepared using disulfide-stabilized MHC monomers can be loaded with peptides within minutes. These tetramers efficiently detects antigen-specific T cells. Furthermore, peptide-MHC tetramers prepared using disulfide-stabilized MHC molecules provide a better staining index for antigen-specific T cell detection compared to multimers prepared with wild-type MHC class I molecules. We demonstrate the value of empty-loadable tetramers that are converted to antigen-specific tetramers by a single-step peptide addition, for the identification of T cells specific to several neo- and cancer-associated antigens in melanoma. Disulfide stabilization has been achieved with several MHC class I allotypes-HLA-A* 02:01, HLA-A*01:01, HLA-A*03:01, HLA-A*11:01, HLA-A*24:02, HLA-B*07:02, and H-2Kb.
Multiple bonds between transition metals and main-group elements. 73. Synthetic routes to rhenium(V) alkyl and rhenium(VII) alkylidyne complexes. X-ray crystal structures of (.eta.5-C5Me5)Re(:O) (CH3)[CH2C(CH3)3] and (.eta.5-C5Me5)(Br)3Re.tplbond.CC(CH3)3 (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple bonds between transition metals and main-group elements. 73. Synthetic routes to rhenium(V) alkyl and rhenium(VII) alkylidyne complexes. X-ray crystal structures of (.eta.5-C5Me5)Re(:O) (CH3)[CH2C(CH3)3] and (.eta.5-C5Me5)(Br)3Re.tplbond.CC(CH3)3Wolfgang A. Herrmann, Josef K. Felixberger, Reiner Anwander, Eberhardt Herdtweck, Paul Kiprof, and Juergen RiedeCite this: Organometallics 1990, 9, 5, 1434–1443Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 May 1990https://doi.org/10.1021/om00119a013RIGHTS & PERMISSIONSArticle Views193Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Effect of diagenesis on elastic and transport properties using computational rock physics in realistic pore microstructure (2009)

We present evolution of elastic and transport properties due to diagenetic effects in realistic pore microstructure using computational rock physics tools. We generate compacted spherical random packs using Granular Dynamics simulation. The output from this process based simulation is gridded at fine scale resolution (5 microns) and used for diagenesis modeling. Different diagenetic methods are employed to recreate the effects of cementation on the initial compacted pack. The microstructures obtained after diagenetic modeling are used for estimating elastic and transport properties. A Finite Element based model is used for elastic properties, while Lattice Boltzmann method is used for estimating permeability. The bulk and shear moduli from the reconstructed micro structures are compared to clean sandstone samples and are found to be reasonably close. We present different diagenetic trends in the elastic, transport and cross‐property domains.
A 24.2-30.5GHz Quad-Channel RFIC for 5G Communications including Built-In Test Equipment (2019)

A wideband quad-channel beamforming RFIC for worldwide 5G infrastructure applications in 130nm SiGe BiCMOS features an Rx single channel gain and NF of 22 and 4dB respectively at a total power consumption of 1.6W. Tx performance includes a P1dB of 18dBm CW and 11.5dBm RMS output power at 3% EVM and 1.8W total power consumption. Beamforming is based on a temperature invariant lumped true time delay and a phase invariant programmable gain amplifier. Integrated built-in test equipment including LO-generation, signal injection and detection enables low-cost RF production testing and array calibration.
Visualization of thermal ablation lesions using cumulative dynamic contrast enhancement MRI (2013)

A novel robust and user friendly method for post-processing dynamic contrast enhanced (DCE) MRI data is presented, which provides reliable real-time delineation of the borders of thermal ablation lesions on low SNR images shortly after contrast agent injection without any model-based curve fitting. Some simple descriptors of the DCE process are calculated in a time efficient recursive manner and combined into a single image reflecting both current and previous enhancement states of each pixel, which allows robust discrimination between tissue areas with different perfusion properties. The resulting cumulative DCE (CDCE) images are shown to exhibit a strong correlation with histopathology and late gadolinium enhancement representations of the thermal damage in soft tissue. It is shown that the outer border of the non-perfused ablation lesion core on CDCE MRI corresponds to the histopathological lesion border. The described method has a potential not only to facilitate thermal ablation outcome assessment, but also to improve detection of infiltrative tumours and reduce the administered contrast agent dose in any DCE scans.
Highly Efficient Bipolar Host Materials with Indenocarbazole and Pyrimidine Moieties for Phosphorescent Green Light-Emitting Diodes (2014)

In this paper, we report bipolar host materials, 6-(2,6-diphenyl-pyrimidin-4-yl)-12,12-dimethyl-6,12,12′-trihydroindeno[1,2-b]carbazole (DPICz1) and 6-(2,6-diphenyl-pyrimidin-4-yl)-12,12-dimethyl-6,12,12′-trihydroindeno[1,2-b]carbazole (DPICz2), with indenocarbazole moiety as a hole-transporting unit and pyrimidine moiety as an electron-transporting unit for highly efficient green phosphorescent organic light-emitting diodes. The synthesized materials show excellent electro-optical properties. Similarly, it also exhibits outstanding thermal and morphological stability due to high glass transition temperature (Tg) of 161 °C and decomposition temperature (Td) of 327–401 °C. Fabricated green phosphorescent organic light-emitting diode shows excellent current and power efficiency of 77.8 cd/A and 62.8 lm/W as well as almost ideal external quantum efficiency of 22.3% at the brightness of 1000 cd/m2.
Additional file 14: of The parameter sensitivity of random forests (2016)

Intra-parameter values display variation for high p/n studies (combined validation data). The parameters sampsize, n tree and m try were analysed by performing pairwise t-tests with a Benjamini-Hochberg adjustment. AUC scores were grouped by parameter values as indicated by colour (orange for sampsize, blue for n tree and pink for m try ). In general, lower intra-parameter values for sampsize, n tree , and m try were found to differ significantly from higher intra-parameter values, with higher parameter values exhibiting a positive correlation with AUC. (TIFF 1207 kb)
A compact factored representation of heterogeneous subsurface scattering (2006)

Many translucent materials exhibit heterogeneous subsurface scattering, which arises from complex internal structures. The acquisition and representation of these scattering functions is a complex problem that has been only partially addressed in previous techniques. Unlike homogeneous materials, the spatial component of heterogeneous subsurface scattering can vary arbitrarily over surface locations. Storing the spatial component without compression leads to impractically large datasets. In this paper, we address the problem of acquiring and compactly representing the spatial component of heterogeneous subsurface scattering functions. We propose a material model based on matrix factorization that can be mapped onto arbitrary geometry, and, due to its compact form, can be incorporated into most visualization systems with little overhead. We present results of several real-world datasets that are acquired using a projector and a digital camera.
The Effect of Network Width on Stochastic Gradient Descent and Generalization: an Empirical Study (2019)

We investigate how the final parameters found by stochastic gradient descent are influenced by over-parameterization. We generate families of models by increasing the number of channels in a base network, and then perform a large hyper-parameter search to study how the test error depends on learning rate, batch size, and network width. We find that the optimal SGD hyper-parameters are determined by a "normalized noise scale," which is a function of the batch size, learning rate, and initialization conditions. In the absence of batch normalization, the optimal normalized noise scale is directly proportional to width. Wider networks, with their higher optimal noise scale, also achieve higher test accuracy. These observations hold for MLPs, ConvNets, and ResNets, and for two different parameterization schemes ("Standard" and "NTK"). We observe a similar trend with batch normalization for ResNets. Surprisingly, since the largest stable learning rate is bounded, the largest batch size consistent with the optimal normalized noise scale decreases as the width increases.
Scalable hardware priority queue architectures for high-speed packet switches (2002)

In packet-switched networks, queueing of packets at the switches can result when multiple connections share the same physical link. To accommodate a large number of connections, a switch can employ link-scheduling algorithms to prioritize the transmission of the queued packets. Due to the high-speed links and small packet sizes, a hardware solution is needed for the priority queue in order to make the link schedulers effective. But for good performance, the switch should also support a large number of priority levels (P) and be able to buffer a large number of packets (N). So a hardware priority queue design must be both fast and scalable (with respect to N and P) in order to be implemented effectively. In this paper we first compare four existing hardware priority queue architectures, and identify scalability limitations on implementing these existing architectures for large N and P. Based on our findings, we propose two new priority queue architectures, and evaluate them using simulation results from Verilog HDL and Epoch implementations.
Crystalline Structure Changes of Molybdenum Silicide Films Deposited by Sputtering and by Coevaporation after Isochronal Annealing (1982)

Crystalline structure changes of molybdenum silicide films after isochronal annealing are studied by x‐ray and transmission electron microscopy. Two types of films deposited by sputtering from a hot pressed source and coevaporation of molybdenum and silicon, with controlled stoichiometry of , are prepared. For both types of depositions, the films that are as‐deposited and annealed at temperatures below 350°C are amorphous, but those annealed between 400° and 600°C show hexagonal . Transformation from hexagonal to tetragonal occurs above 700°C for the coevaporated film, whereas it proceeds gradually above 800°C for the sputtered film. A carbon stabilized phase is observed above 750°C for the sputtered film, which suggests that the sputtered film is contaminated by carbon during the deposition. Formation of the Mo‐rich silicides and above 700°C is evidence that the deposited films become Mo‐rich during the annealing due to slight oxidation of the film surface.
Software defined photon counting system for time resolved x-ray experiments (2007)

The time structure of synchrotron radiation allows time resolved experiments with sub-100 ps temporal resolution using a pump-probe approach. However, the relaxation time of the samples may require a lower repetition rate of the pump pulse compared to the full repetition rate of the x-ray pulses from the synchrotron. The use of only the x-ray pulse immediately following the pump pulse is not efficient and often requires special operation modes where only a few buckets of the storage ring are filled. We designed a novel software defined photon counting system that allows to implement a variety of pump-probe schemes at the full repetition rate. The high number of photon counters allows to detect the response of the sample at multiple time delays simultaneously, thus improving the efficiency of the experiment. The system has been successfully applied to time resolved scanning transmission x-ray microscopy. However, this technique is applicable more generally.