gebhart/patrepeval huggingface dataset:
Review of Downhole Wireless Communication Techniques (2014)

Abstract Real-time permanent monitoring and control is essential to maximize production from oil and gas wells. An interdisciplinary approach is needed for any cost-effective solution that can perform and be sustained in the harsh downhole environment. For open hole horizontal wells, providing power and data through an umbilical is very challenging. Wireless communication is the essential component of any downhole monitoring and control solution in this situation. A wireless solution can also significantly reduce the complexity and cost associated with the wired solutions. In this paper various wireless communication techniques are classified and an extensive review of state-of-the-art downhole applications is presented. Advantages and limitations of each technique are discussed and recommendations are made of possible solutions.
Structure and Dynamics of Zinc-Neutralized Sulfonated Polystyrene Ionomers (2011)

Scanning transmission electron microscopy (STEM), X-ray scattering, and dielectric relaxation spectroscopy were used to investigate the structure and dynamics of Zn-neutralized sulfonated polystyrene (SPS) ionomers. STEM and X-ray scattering revealed the presence of spherical aggregates ∼2 nm in diameter. Successful fitting of scattering data to the Kinning − Thomas modified hard sphere model provided information on aggregate diameter, radius of closest approach, and number density. The analysis revealed that aggregate size is independent of degree of sulfonation and neutralization level, and that aggregate composition becomes increasingly ionic with increasing neutralization. Two segmental relaxations were identified in dielectric loss spectra corresponding to cooperative motion of chain segments in the matrix and motions of segments restricted by aggregates. Additionally, a Maxwell−Wagner−Sillars interfacial polarization process was revealed, with relaxation times in good agreement with predictions from a simple spherical polarization model.
Kijimicin, a polyether antibiotic. (1990)

A new polyether antibiotic, kijimicin was found in culture nitrate of an Actinomadura sp. MI215-NF3, which was isolated from a soil sample collected at Bunkyo-ku, Tokyo, Japan. The antibiotic showed higher anticoccidial activity than monensin or salinomycin and further studies are now in progress.
User-friendly, ultra-fast simulation of detector DQE(f) (2013)

Development of the indirect scintillating detector is hindered not only by the cost and lead-time of manufacturing but also the computational resources required for numerical modeling. The simulation is bogged down by the number of x-ray photons (gammas) required to duplicate the experimental flood image ensemble necessary to characterize the noise power spectrum (NPS), a key input into the detective quantum efficiency (DQE). The simulation approach presented in this work exploits our previously reported procedure named Fujita-Lubberts- Swank (FLS)6 . This novel technique computes the Lubberts NPS from an ensemble of single gamma point spread functions (PSF) and, as a result, allows for a significant reduction in the number of simulated particles, enabling full DQE(f) simulations with optical transport in less than one CPU-hour. For a given detector and spectrum, the FLS execution time is determined primarily by the number of gamma and optical photons initiated. The optimal number of each varies with the detector specifics. In this work, we present a different simulation paradigm in which Geant4 was customized to allow for the user to specify the quantities of detected gammas, and detected opticals per gamma. These quantities were empirically shown to be constant over a small selection of different detector types. While work still needs to be done to explore the range of detectors for which this technique will work, we demonstrate a concept which brings added convenience and efficiency to FLS detector simulations.
Fabrication of 4H-SiC Floating Junction Schottky Barrier Diodes (Super-SBDs) and their Electrical Properties (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
NAT10 and DDX21 Proteins Interact with RNase H1 and Affect the Performance of Phosphorothioate Oligonucleotides (2022)

RNase H1-dependent phosphorothioate oligonucleotides (PS-ASOs) have been developed to treat various diseases through specific degradation of target RNAs. Although many factors or features of RNA and PS-ASOs have been demonstrated to affect antisense activity of PS-ASOs, little is known regarding the roles of RNase H1-associated proteins in PS-ASO performance. In this study, we report that two nucleolar proteins, NAT10 and DDX21, interact with RNase H1 and affect the potency and safety of PS-ASOs. The interactions of these two proteins with RNase H1 were determined using BioID proximity labeling in cells and confirmed biochemically. Reduction of NAT10 and DDX21 decreased PS-ASO activity in cells, and purified NAT10 and DDX21 proteins enhanced RNase H1 cleavage rates, indicating that these two proteins facilitate RNase H1 endoribonuclease activity. Consistently, reduction of these proteins increased the levels of R-loops, and impaired pre-rRNA processing. In addition, reduction of the two proteins increased the cytotoxicity of toxic PS-ASOs, and treatment of toxic PS-ASOs also altered the localization of these proteins. Together, this study shows for the first time that NAT10 and DDX21 interact with RNase H1 protein and enhance its enzymatic activity, contributing to the potency and safety of PS-ASOs.
Correlation power analysis using bit-level biased activity plaintexts against AES cores with countermeasures (2014)

Advanced encryption standard (AES) cores suffer from information leakage through power supply currents, even with the wave dynamic differential logic (WDDL) known as one of the most tolerable countermeasure design styles against side channel attacks (SCA). The set of plaintexts having bitlevel biased activities are produced with a known secret key and used for diagnosing the vulnerability of AES cores in their development phases. The CPA with biased plaintexts revealed 128-bit secret keys with less than 4,000 traces from the WDDL AES core both by the measurements and simulations of power supply currents. The core was physically structured by using a 65-nm CMOS standard cell library and assembled on a test vehicle of “SPACES explorer” having an on-board 1-ohm resistor for measuring power supply currents. The derived knowledge should be useful in driving the design of AES cores to be much less prone to information leakage through power supply current and electromagnetic measurements.
Fine temporal analysis of DHT transcriptional modulation of the ATM/Gadd45g signaling pathways in the mouse uterus (2008)

In rodents, the uterus of a mature female undergoes changes during the uterine cycle, under the control of steroid hormones. 5alpha-Dihydrotestosterone (DHT) is recognized to play an important role in the regulation of androgen action in normal endometrium. Using microarray technology, a screening analysis of genes responding to DHT in the uterus of ovariectomized mice, has allowed us to highlight multiple genes of the ATM/Gadd45g pathway that are modulated following exposure to DHT. Two phases of regulation were identified. In the early phase, the expression of genes involved in the G2/M arrest is rapidly increased, followed by the repression of genes of the G1/S checkpoint, and by the induction of transcriptional regulators. Later, i.e. from 12 to 24 hr, genes involved in G2/M transition, cytoarchitectural and lipid-related genes are stimulated by DHT while immunity-related genes appear to be differentially regulated by the hormone. These results show that a physiological dose of DHT induces the transcription of genes promoting the cell cycle progression in mice. Profile determination of temporal uterine gene expression at the transcriptional level enables us to suggest that the DHT modulation of genes involved in ATM/Gadd45g signaling in an ATM- or p53-independent manner, could play an important role in the cyclical changes of uterine cells in the mouse uterus.
Broadband hot electron generation for solar energy conversion with plasmonic titanium nitride (2017)

Plasmonic TiN decorated TiO2 nanowires support 4 times larger generation of over-barrier hot electrons than the Au/TiO2 system resulting in an enhanced photoelectrochemical water splitting activity due to TiN broader plasmonic resonance and improved interface properties.
APPLICATIONS ARE INVITED FOR SITE ENGINEER (ON CONTRACTUAL BASIS) FOR THE EXTENSION OF BUILDING PROJECT AT KOLKATA REGIONAL OFFICE (2014)

Minimum qualification required: Degree / Diploma in Civil Engineering. Site Engineer should have work experience from CPWD/PWD who should have handled projects at least for a worth of Rs.5 crores or more. Suitable persons may apply and forward their application together with the resume, experience, and expected salary to:
ChemInform Abstract: Asymmetric Darzens Condensation on Chiral η6Cr(CO)3 Complexed Benzaldehydes. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Non-invasive assessment of mechanical property changes with cell growth in a polymer-based vascular graft using ultrasound elasticity imaging (2011)

Mechanical strength is a key design factor in engineered vascular grafts for maintaining high burst pressure while preserving compliance of the native vessels. To date, most assessments are made invasively at the end of cell culture and hence such measurements cannot be correlated with cell growth. Therefore, non-invasive monitoring of the changes in mechanical properties as cells grow is essential to optimize the functionality of engineered vascular grafts. In this study, the mechanical property change of a cell-seeded polymer-based scaffold in a bioreactor is monitored using ultrasound (US) elasticity imaging (UEI).
GS-3583, a novel FLT3 agonist Fc fusion protein, to expand conventional dendritic cells in healthy volunteers. (2021)

2559 Background: Conventional dendritic cells subtype 1 (cDC1) play a vital role in the priming and expansion of tumor specific CD8+ T cells and their recruitment to tumor microenvironment (TME). However, cDC1s are often underrepresented in the TME. Systemic administration of Fms-like tyrosine kinase 3 ligand (FLT3L), a hematopoietic growth factor that binds to FLT3 on myeloid and lymphoid progenitor cells, leads to expansion of cDC1s in the periphery which can then be recruited into the TME. We hypothesize that FLT3 pathway stimulation using GS-3583, a FLT3 agonist Fc fusion protein, has the potential to promote T cell mediated anti-tumor activity. Methods: This was a first-in-human placebo-controlled study of GS-3583 in healthy volunteers to evaluate the safety, PK, and PD of escalating single doses (ranging from 75μg to 2000μg) of GS-3583. The study was blinded to the subjects and the investigator. Each dose cohort enrolled 8-12 healthy subjects who received GS-3583 or placebo as single IV infusion at 3:1 ratio. Subjects were observed in the phase 1 unit for 15 days and then for 12 weeks as outpatients. As part of the PD evaluation, we investigated the changes in the number of cDC1s and cDC subtype 2 (cDC2) cells. Results: As of 8 th Feb 2021, selected safety, PK and PD data from the first 3 cohorts were available. GS-3583 was well tolerated and all subjects had been discharged. To date, there have been no serious or grade 3 or higher adverse events. Preliminary PK analysis suggested dose-dependent increase in GS-3583 exposure (AUC and C max ). Preliminary PD analysis shows that administration of GS-3583 resulted in dose-dependent increases in cDC1/cDC2 cells that peaked at day 5 or day 8 and returned to baseline within three weeks of drug administration. Conclusions: GS-3583 was safe and well tolerated and induced dose dependent expansion of dendritic cells in the periphery. In patients with cancer, this increase in dendritic cells can be utilized to enhance anti-tumor responses to immuno-oncology therapies.[Table: see text]
The quality of mean and variance estimates for normal and lognormal data when the underlying distribution is misspecified (1991)

Abstract Theoretical and simulation results are employed to evaluate mean and variance estimates for normal data when a lognormal distribution is assumed and for lognormal data when a normal distribution is assumed. Misspecifying the distribution leads to the use of suboptimal estimation methods. However, the results show that the suboptimal methods still produce estimators of good quality (low bias and variance) relative to the minimum variance unbiased estimators for each distribution, at least when practical efficiency is considered.
Weighted sequence motifs as an improved seeding step in microRNA target prediction algorithms (2005)

We present a new microRNA target prediction algorithm called TargetBoost, and show that the algorithm is stable and identifies more true targets than do existing algorithms. TargetBoost uses machine learning on a set of validated microRNA targets in lower organisms to create weighted sequence motifs that capture the binding characteristics between microRNAs and their targets. Existing algorithms require candidates to have (1) near-perfect complementarity between microRNAs' 5' end and their targets; (2) relatively high thermodynamic duplex stability; (3) multiple target sites in the target's 3' UTR; and (4) evolutionary conservation of the target between species. Most algorithms use one of the two first requirements in a seeding step, and use the three others as filters to improve the method's specificity. The initial seeding step determines an algorithm's sensitivity and also influences its specificity. As all algorithms may add filters to increase the specificity, we propose that methods should be compared before such filtering. We show that TargetBoost's weighted sequence motif approach is favorable to using both the duplex stability and the sequence complementarity steps. (TargetBoost is available as a Web tool from http://www.interagon.com/demo/.).
The Mitochondrion Is a Site of Trypanocidal Action of the Aromatic Diamidine DB75 in Bloodstream Forms of Trypanosoma brucei (2021)

Human African trypanosomiasis (HAT) is a fatal tropical disease caused by infection with protozoans of the species Trypanosoma brucei gambiense and T. b. rhodesiense. An oral prodrug, DB289, is a promising new therapy undergoing phase III clinical trials for early-stage HAT. DB289 is metabolically converted to the active trypanocidal diamidine DB75 [2,5-bis(4-amidinophenyl)furan]. We previously determined that DB75 inhibits yeast mitochondrial function (C. A. Lanteri, B. L. Trumpower, R. R. Tidwell, and S. R. Meshnick, Antimicrob. Agent Chemother. 48:3968-3974, 2004). The purpose of this study was to investigate if DB75 targets the mitochondrion of T. b. brucei bloodstream forms. DB75 rapidly accumulates within the mitochondria of living trypanosomes, as indicated by the fluorescent colocalization of DB75 with a mitochondrion-specific dye. Fluorescence-activated cell sorting analysis of rhodamine 123-stained living trypanosomes shows that DB75 and other trypanocidal diamidines (pentamidine and diminazene) collapse the mitochondrial membrane potential. DB75 inhibits ATP hydrolysis within T. brucei mitochondria and appears to inhibit the oligomycin-sensitive F1F0-ATPase and perhaps other ATPases. DB75 is most likely not an inhibitor of electron transport within trypanosome mitochondria, since DB75 fails to inhibit mitochondrial respiration when glycerol-3-phosphate is used as the respiratory substrate. However, DB75 inhibits whole-cell respiration (50% inhibitory concentration, 20 μM) at drug concentrations and incubation durations that also result in the dissipation of the mitochondrial membrane potential. Taken together, these findings suggest that the mitochondrion is a target of the trypanocidal action of DB75.
Analytical Approach of Tractoring Strategies in Coiled Tubing Applications in Horizontal Wells (2017)

Abstract In the present paper we discuss the potential of increasing coiled tubing reach with well tractor applications. Several scenarios of tractoring are analytically investigated with regard to the benefits of adding tractoring at early stages of the well intervention procedure. The analytical approach takes into consideration the force balance at compression and tension states, and solves the buckling condition with regard to different parameters.
Mapping strategies for the PERCS architecture (2012)

The PERCS system was designed by IBM in response to a DARPA challenge that called for a high-productivity high-performance computing system. The IBM PERCS architecture is a two level direct network having low diameter and high bisection bandwidth. Mapping and routing strategies play an important role in the performance of applications on such a topology. In this paper, we study mapping strategies for PERCS architecture, that examine how to map tasks of a given job on to the physical processing nodes. We develop and present fundamental principles for designing good mapping strategies that minimize congestion. This is achieved via a theoretical study of some common communication patterns under both direct and indirect routing mechanisms supported by the architecture.
Chirped-pulse amplification of 55-fs pulses at a 1-kHz repetition rate in a Ti:Al_2O_3 regenerative amplifier (1993)

40-fs pulses are stretched to 372 ps by an all-reflective-optics stretcher with 1200-line/mm holographic gratings and are then amplified to an energy of 0.7 mJ in a regenerative amplifier. After compression, 0.35-mJ, 55-fs transform-limited pulses are produced.
Catalytic Cleavage of Ether CO Bonds by Pincer Iridium Complexes (2014)

Abstract The development of efficient catalytic methods to cleave the relatively unreactive CO bonds of ethers remains an important challenge in catalysis. Building on our group’s recent work, we report the dehydroaryloxylation of aryl alkyl ethers using pincer iridium catalysts. This method represents a rare fully atom‐economical method for ether CO bond cleavage.
Adrenalectomy promotes a permanent decrease of plasma corticoid levels and a transient increase of apoptosis and the expression of Transforming Growth Factor β1 (TGF-β1) in hippocampus: effect of a TGF-β1 oligo-antisense (2006)

The changes in both the pattern and the magnitude of apoptotic-cell morphology observed 2 and 5 days after ADX suggest that, as a consequence of the reduction of corticosteroids, some trophic mechanisms restricting cell death to a particular time window are elicited. Sustained intracerebral administration of TGF-beta1 ASO increased the apoptosis promoted by ADX, suggesting that TGF-beta1 plays an anti-apoptotic role in vivo in hippocampus.
Data from Synergistic Enhancement of CD8<sup>+</sup> T Cell–Mediated Tumor Vaccine Efficacy by an Anti–Transforming Growth Factor-β Monoclonal Antibody (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Transforming growth factor-β (TGF-β) is an immunosuppressive cytokine, having direct suppressive activity against conventional CD4&lt;sup&gt;+&lt;/sup&gt; and CD8&lt;sup&gt;+&lt;/sup&gt;T cells and natural killer cells, thereby inhibiting tumor immunosurveillance. Here, we investigated possible synergy between anti–TGF-β (1D11) and a peptide vaccine on induction of antitumor immunity, and the mechanisms accounting for synergistic efficacy.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; The effect of combination treatment with a peptide vaccine and anti–TGF-β was examined in a subcutaneous TC1 tumor model, as well as the mechanisms of protection induced by this treatment.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Anti–TGF-β significantly and synergistically improved vaccine efficacy as measured by reduction in primary tumor growth, although anti–TGF-β alone had no impact. The number of tumor antigen–specific CTL with high functional avidity as measured by IFN-γ production and lytic activity was significantly increased in vaccinated mice by TGF-β neutralization. Although TGF-β is known to play a critical role in CD4&lt;sup&gt;+&lt;/sup&gt;Foxp3&lt;sup&gt;+&lt;/sup&gt; Treg cells, Treg depletion/suppression by an anti-CD25 monoclonal antibody (PC61) before tumor challenge did not enhance vaccine efficacy, and adding anti–TGF-β did not affect Treg numbers in lymph nodes or tumors or their function. Also, TGF-β neutralization had no effect on interleukin-17–producing T cells, which are induced by TGF-β and interleukin-6. Absence of type II NKT cells, which induce myeloid cells to produce TGF-β, was not sufficient to eliminate all sources of suppressive TGF-β. Finally, the synergistic protection induced by anti–TGF-β vaccine augmentation was mediated by CD8&lt;sup&gt;+&lt;/sup&gt; T cells since anti-CD8 treatment completely abrogated the effect.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; These results suggest that TGF-β blockade may be useful for enhancing cancer vaccine efficacy. (Clin Cancer Res 2009;15(21):6560–9)&lt;/p&gt;&lt;/div&gt;
Antiangiogenic and Antitumor Effects of Bevacizumab in Patients With Inflammatory and Locally Advanced Breast Cancer (2006)

Bevacizumab has inhibitory effects on VEGF receptor activation and vascular permeability, and induces apoptosis in tumor cells.
ONLINE MV PD MONITORING SYSTEM: IMPROVEMENTS ON THE AUTOMATIC ASSESSMENT OF THE INSULATION SYSTEMS (2021)

The demand for online partial discharge (PD) monitoring systems able to evaluate the health status of the electrical assets of a distribution network is currently wide-spreading. The requirements triggering such requests are better power quality, reduction of the failure rate, and the early management of the maintenance and repair actions to reduce their costs. Moreover, the increasing aging of the population of assets in the field is raising concerns about the long-term reliability of the networks. To be effective in providing useful information about the status of the insulation systems, an online MV PD monitoring system is expected to guarantee the best sensitivity of its sensors and to ensure placements offering the highest capability of detecting incoming PD signals from the components of the electrical assets. In the current paper, the analysis of the PD signals initiated by artificial defects placed within GIS metal-clad MV Switchgears (SG) and detected from different typologies of sensors is reported and discussed. The goal is to define the optimal configuration and position of the sensors to provide the online MV PD monitoring system with the best sensitivity from the field. The PD analysis is then carried out by expert systems able to autonomously assess the conditions of the insulation systems, supporting the decision-making process for the condition-based maintenance of the electrical assets of the grid.