gebhart/patrepeval huggingface dataset:
Use of cross-correlation for ratio measurements in mass spectrometry (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUse of cross-correlation for ratio measurements in mass spectrometryAhmet. Celikkaya and Sefik. SuzerCite this: Anal. Chem. 1986, 58, 14, 3256–3257Publication Date (Print):December 1, 1986Publication History Published online1 May 2002Published inissue 1 December 1986https://doi.org/10.1021/ac00127a075RIGHTS & PERMISSIONSArticle Views44Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (236 KB) Get e-Alerts Get e-Alerts
Tobacco lines with high copy number of replicating recombinant geminivirus vectors after biolistic DNA delivery (1992)

Summary The feasibility of obtaining clonal lines with replicating, multicopy geminivirus vectors by direct DNA trans‐formation of cultured tobacco cells was studied. The replicating vectors pTGA32 and pST31 are based on the tomato golden mosaic virus (TGMV) A genome and encode the neomycin phosphotransferase type II (NPT‐II) enzyme that confers kanamycin resistance to plant cells. Following introduction into plant cells, unit‐length viral genomes were released from the tandem repeats and replicated. In protoplasts, replication of unit‐length pTGA32 and pST31 was about as efficient as replication of unit‐length DNA A from plasmid pTGA26, which contains 1.5 copies of wild‐type DNA A. Tobacco suspension culture cells were bombarded with the recombinant DNA A constructs and selected for kanamycin resistance. The number of kanamycin‐resistant clones per bombardment was about the same when the TGMV DNA A vectors or a non‐replicating plasmid (pLC14) which also encodes NPT‐II was used. Replicating, unit‐length DNA A in up to approximately 1000 copies per cell was found in about 10% of the kanamycin‐resistant clones selected following bombardment of cells with TGMV vectors. The results suggest that geminiviruses may serve as useful multicopy vectors in cultured cells.
Gezielte Früherkennung und risikoadaptierte Therapie (2019)

Gezielte Früherkennung am Beispiel des Deutschen Konsortiums Familiärer Brust- und Eierstockkrebs / Rita Schmutzler Modelle für eine erfolgreiche, risikoadaptierte Therapie – am Beispiel der akuten lymphatischen Leukämie / Nicola Gökbuget Modelle für eine erfolgreiche, risikoadaptierte Therapie – am Beispiel des Hodgkin-Lymphoms / Andreas Engert Modelle für eine erfolgreiche, risikoadaptierte Therapie – am Beispiel der Keimzelltumoren des Mannes / Carsten Bokemeyer
Scintillation properties of ceramic Ce-doped Gd<inf>3</inf>(Ga,Al)<inf>5</inf>O<inf>12</inf> (2013)

Ceramic Ce 0.1% doped Gd <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> (Ga,Al) <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</sub> scintillator fabricated by Konoshima Chemical was evaluated. In X-ray induced radioluminescence, intense emission peak appeared around 530 nm. When <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">137</sup> Cs 662 keV γ-ray was irradiated, scintillation light yield turned out to be 70000 ph/MeV by using Si-APD. Scintillation decay timewas a typical value of Ce-doped garnet materials, ~ 100 ns.
Computational studies on FK506: conformational search and molecular dynamics simulation in water (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComputational studies on FK506: conformational search and molecular dynamics simulation in waterJulianto Pranata and William L. JorgensenCite this: J. Am. Chem. Soc. 1991, 113, 25, 9483–9493Publication Date (Print):December 1, 1991Publication History Published online1 May 2002Published inissue 1 December 1991https://pubs.acs.org/doi/10.1021/ja00025a010https://doi.org/10.1021/ja00025a010research-articleACS PublicationsRequest reuse permissionsArticle Views240Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Observation of Amyloid-Like Fibers of the Sup35 Protein from Saccharomyces Cerevisiae (2000)

Abstract In the yeast Saccharomyces cerevisiae, [PST] acts as an epigenetic modifier of translation termination efficiency. [PSI+] can be passed through generations of yeast cells via changes in protein conformation rather than changes in DNA or RNA, and has thus been referred to as a yeast prion. The [PSI+] determinant is the Sup35 protein. Sup35 can exist in two states - soluble and insoluble. Soluble Sup35 functions in translation termination, but when insoluble, stop codons are read through, resulting in incorrect protein products. Sup35 is composed of three distinct domains, N, M, and C. The N region is rich in glutamine and asparagine and is required for the [PST] phenotype to exist. M is a highly charged domain, and no specific function has been assigned to it. C is essential in yeast, as it is responsible for translation termination. The insoluble form of Sup35 has characteristics reminiscent of other prion proteins - in vitro it binds to the dye Congo Red and it exhibits apple green birefringence in polarized light.
Reliability of vapor-grown planar In/sub 0.53/Ga/sub 0.47/As/InP p-i-n photodiodes with very high failure activation energy (1988)

The mean time to failure (MTTF) was measured for a statistically significant population of planar In/sub 0.53/Ga/sub 0.47/As/InP heterostructure p-i-n photodetectors at several elevated temperatures. The probability for failure is fit to a log-normal distribution, with the result that the width of the failure distribution is sigma =0.55+or-0.2, and is roughly independent of temperature. From the temperature dependence of MTTF data, it is found that the failure mechanism is thermally activated, with an activation energy of less than 1.5+or-0.2 eV measured in the temperature range of 170-250 degrees C. This extrapolates to a MTTF of less than 0.1 failure in 10/sup 9/ h (or <0.1 FIT) at 70 degrees C, indicating that such devices are useful for systems requiring extremely high reliable components, even if operated at elevated temperatures for significant time periods. This activation energy is the highest value reported for In/sub 0.53/Ga/sub 0.47/As/InP photodetectors, and is significantly higher than the energies of approximately 0.85 eV often suspected for these devices.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Dynamic Response and Damage Estimation of Infant Brain for Vibration (2013)

The purpose of this paper is to clarify the mechanical generation mechanism of acute subdual hematoma, which is a severe injury in infants, by performing experiments and finite element analysis. The acute subdural hematoma in infants is caused by accidents such as falling or abuse such as shaking. This paper describes the shaking events. In the experiments, we used a 6-month-old anthropometric dummy and a vibration exciter, which can set the parameters. The dummy was fixed to the exciter at the chest, which it was given the vibration. The head model of the dummy is transparent, and the brain behavior can be visualized. In finite element analysis, we used a model that has been converted to the 6-month-old head through the adult head by the method of free-form deformation (FFD) and scaling. Also, we performed the simulation of shaking events as input acceleration and angular velocity of the head obtained in the experiments. We measured the stretch ratio of the bridging veins, which connect the skull and the brain, then compared this with the ratio to the threshold (1.5). In this study, we examined the effect on the infant head of shaking action, along with the risk.
NeuroChat with Professor W. Michael Caudle (2019)

ADVERTISEMENT RETURN TO ISSUEPREVEditorialNEXTNeuroChat with Professor W. Michael CaudleCraig W. LindsleyCraig W. LindsleyMore by Craig W. Lindsleyhttp://orcid.org/0000-0003-0168-1445Cite this: ACS Chem. Neurosci. 2019, 10, 6, 2625–2627Publication Date (Web):June 19, 2019Publication History Published online19 June 2019Published inissue 19 June 2019https://pubs.acs.org/doi/10.1021/acschemneuro.9b00237https://doi.org/10.1021/acschemneuro.9b00237editorialACS PublicationsCopyright © 2019 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views593Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (907 KB) Get e-AlertscloseSUBJECTS:Central nervous system,Neuroscience,Students,Teaching and learning methods,Toxicology Get e-Alerts
Antifungal Susceptibility Profile of ClinicalTrichosporon asahiiandTrichosporon asteroidsIsolates Identified by Molecular Methods (2009)

(2009). Antifungal Susceptibility Profile of Clinical Trichosporon asahii and Trichosporon asteroids Isolates Identified by Molecular Methods. Journal of Chemotherapy: Vol. 21, No. 3, pp. 360-362.
Cooperative Lewis acidity in borane-substituted fluorophosphonium cations (2016)

A series of aryl-difluorophosphoranes are converted to give fluorophosphonium salts [Ph2PF(o-C6X4BR2)](+) (X = H, F; R = Cy, Mes). The proximity of the two weakly Lewis acidic fluorophosphonium and borane moieties results in enhanced Lewis acid catalytic reactivity.
C/EBPα is a major activator for the transcription of rat Cu/Zn superoxide dismutase gene in liver cell (1997)

The rat Cu/Zn superoxide dismutase (SOD1) is expressed in all tissues. Sequence analysis of the SOD1 promoter region showed that none of the cis-elements of hepatocyte-specific nuclear factors (HNF) were observed. The cis-element of C/EBP alpha in the proximal region of the SOD1 promoter and the high level of C/EBP alpha in the liver tissue led us to focus on the transcriptional regulation of the SOD1 gene by C/EBP alpha. Cotransfection assays with the plasmid expressing transcription factor C/EBP alpha showed that C/EBP alpha transactivated SOD1 gene by 27 fold. The marked transactivation and direct binding of C/EBP alpha to the SOD1 promoter were confirmed by deletion analyses and mobility shift assays. These results suggested that C/EBP alpha plays a major role in the tissue distribution of SOD1.
MCL‐R2 ELDERLY: A PHASE III STUDY OF THE EUROPEAN MCL NETWORK ASSESSING EFFICACY OF ALTERNATING IMMUNOCHEMOTHERAPY (R‐CHOP / R‐HAD) AND a RITUXIMAB‐LENALIDOMIDE MAINTENANCE (2017)

Background: In prior studies, we have established a cytarabine-containing induction regimen as the standard approach in younger MCL patients (Hermine, Lancet 2016) whereas rituximab maintenance has improved survival rates both in older patients (Kluin-Nelemans, NEJM 2012) and younger patients after autologous stem cell transplantation (Le Gouill, ASH 2016). In addition, a recent phase II study suggested high efficacy with a rituximab-lenalidomide (R2) combination (Ruan, NEJM 2015). Methods: The MCL-R2 Elderly trial is a phase III study of the European MCL network comparing 8 cycles of R-CHOP versus an alternating induction (3 cycles of R-CHOP / 3 cycles of R-HAD) in older MCL patients followed by combined maintenance (R2) vs. rituximab alone in patients responding to induction. The primary endpoint of the trial is to evaluate whether the addition of lenalidomide to standard rituximab-maintenance improves outcome compared to standard rituximab maintenance after response to induction chemotherapy. Secondary endpoints include overall survival, response rate according to IWG criteria and other efficacy parameters, safety, and MRD (minimal residual disease). For induction, randomization is stratified according to country and MIPI and for maintenance additionally according to type of, and response to, induction. Key inclusion criteria are patient ≥60 years of age with untreated MCL ineligible for autologous transplant, but fit enough to tolerate the R-HAD therapy, Ann-Arbor stage II-IV and ECOG PS 0–2. Key exclusion criteria are poor renal, hepatic, or bone marrow functions unless related to lymphoma, HIV, HCV positivity, active HBV infection, poor cardiac function, CNS involvement by lymphoma, contraindication for medical DVT prophylaxis, and prior other malignancies if not disease-free for ≥5 years. Evaluation including detection of MRD is performed after cycle 4 of induction, at the end of induction treatment, every 6 months during maintenance and follow-up. A maximum number of 633 subjects will be randomized for induction and 443 for maintenance. Results: Since November 2013, 285 patients have-been included, with France, Belgium, Germany, Netherlands, Portugal, and Spain currently recruiting and Poland being initiated within the next weeks. So far, 178 patients have been randomized for the maintenance part which is in line with the expected number of patients. At least one MRD sample has been collected from 212 of 263 cases (81%). An IDMC will regularly review safety issue and especially secondary primary malignancies. So far, the IDMC has analyzed the clinical course of the first 60 patients randomized for maintenance with 25 patients receiving lenalidomide maintenance for more than 6 months and recommended continuation of the study without any safety concerns. Conclusion: The study is ongoing and open for inclusions with an accrual rate that correspond to our hypothesis. Keywords: Ara-C; lenalidomide; mantle cell lymphoma (MCL).
Solid rocket booster thermal protection system removal using robotics (1993)

The Mobile Robotic Hydrolasing System (MRHS) was designed to remove the Thermal Protection System (TPS) from the Space Shuttle's Solid Rocket Boosters (SRB) during disassembly operations at Kennedy Space Center (KSC). The MRHS uses high pressure water (approximately 15,000 psi @ 23 gal/min.) to strip the TPS from the SRB case. This process is called hydrolasing. The system is composed of a 6 4 s articulated robotic arm that incorporates a high pressure water system (straight and rotating tip nozzles and hoses), an electronic controller and its associated instrumentation. All this equipment is mounted on a modified mobile crane cany deck. A series of software programs, executed by the controller, guides the robotic arm along the SRB case and aims the high pressure water in a predetermined stripping path. The Space Shuttle's reusable SRBs are protected with a Thermal Protection System (Instafoam, cork, KSNA-cork and epoxy compound) to avoid hardware damage during flight, splashdown and recovery phases. During disassembly operations at Hangar AF, Cape Canaveral Air Force Station (CCAFS), this TPS must be stripped from the SRBs to be able to demate and refurbish the SRB segments. This operation is accomplished by spraying high pressure water (approximately 15,000 psi G3 23 gal/min.) at the SRB areas where TPS is to be removed. This process is called hydrolasing. Hydrolasing may be performed manually. High pressure water guns are used to strip the TPS from the SRB segments. Trained personnel aim ' Softwardmechanical systems engineer. 2 ~tectrica~ systems engineer. Copylght 8 199.9 by the American Institute of Aeronautiw and Asbonauti*l. Inc. No copyright Is asserted in the United States under Title 17, US. Code. The United States has a royalty-free llmnse lo exerdse all rlghts under the capyrlght claimed herein for Governmental purposes. All other rights are reserved by the oopvrlqht owner. 'CJ these guns at the SRB areas to be cleaned. Manual hydrolasing poses a safety hazard to the operator due to the high pressure water used in the process as well as the exposure to flying TPS debris from the stripping operation. During hydrolasing operations, the operator must wear a special protective suit, which is purged with breathing air. He has to strap the hydrolasing gun to his shoulder to be able to control the direction of water flow with his body. Due to the high pressure of the water, the operator effort required to constantly control the gun is large. This operation has the potential of producing muscle and nerve damage to the operator's shoulder and arm. Manual hydrolasing operation is hazardous due to the potential risk of personnel injury by the high pressure water. Furthermore, it is a source of fatigue to the operator because of the amount of effort required to aim and maintain the hydrolasing gun pointing at the SRB case.
Absence of MEF2 binding to the A/T-rich element in the muscle creatine kinase (MCK) enhancer correlates with lack of early expression of the MCK gene in embryonic mammalian muscle. (1997)

During skeletal muscle development, different types of muscle fibers are generated, which express different combinations of muscle-specific gene products. For example, the muscle creatine kinase gene (MCK) is highly expressed in fetal but not embryonic myotubes. We performed transient transfections of CAT reporter constructs, driven by the MCK promoter with variable lengths of 5'-flanking sequence, into primary cultures of embryonic and fetal muscle cells. Reporter activity was observed in fetal but not embryonic muscle cells. We assayed the ability of nuclear extracts prepared from embryonic and fetal muscle and C2C12 myotubes to bind specific regulatory elements in the MCK enhancer. The profile of DNA/protein complexes resulting from electrophoretic mobility shift assays was qualitatively the same with all extracts used when the oligonucleotide probes represented the MCK-E-box, MHox site, CArG-box, and AP2 site. In contrast, no binding activity to the MEF2 site was observed with embryonic nuclear extract. Interestingly, MEF2 mRNAs and proteins were detected in both fetal and embryonic muscle, with the exception of the MEF2D1b isoform, which is restricted to fetal muscle. Furthermore, we found that protein phosphatase inhibitors included in the preparation of embryonic nuclear extracts or added to the medium of transfected embryonic myotubes can restore MEF2 DNA binding activity, as well as reporter activity driven by the MCK promoter and partial transcriptional activation of the endogenous MCK gene. We propose that phosphorylation of MEF2 regulates its activity and represents an important aspect of the mechanism controlling stage-specific transcription during skeletal myogenesis.
Unravelling the diversity of glycoside hydrolase family 13 α-amylases from Lactobacillus plantarum WCFS1 (2019)

The substrate range as well as the biochemical properties exhibited by Lp_2757 maltogenic α-amylase suggest that this enzyme could be a very promising enzyme for the hydrolysis of α-1,4 glycosidic linkages present in a broad number of starch-carbohydrates, as well as for the investigation of an hypothetical transglucosylation activity under appropriate reaction conditions.
Role of Shear and Longitudinal Waves in Stone Comminution by Lithotripter Shock Waves (2006)

Mechanisms of stone fragmentation by lithotripter shock waves were studied. Numerically, an isotropic‐medium, elastic‐wave model was employed to isolate and assess the importance of individual mechanisms in stone comminution. Experimentally, cylindrical U‐30 cement stones were treated in an HM‐3‐style research lithotripter. Baffles were used to block specific waves responsible for spallation, squeezing, or shear. Surface cracks were added to stones to simulate the effect of cavitation, and then tested in water and glycerol (a cavitation suppressive medium). The calculated location of maximum stress compared well with the experimental observations of where cracks naturally formed. Shear waves from the shock wave in the fluid traveling along the stone surface (a kind of dynamic squeezing) led to the largest stresses in the cylindrical stones and the fewest shock waves to fracture. Reflection of the longitudinal wave from the back of the stone — spallation — and bubble‐jet impact on the proximal and distal faces of the stone produced lower stresses and required more shock waves to fracture stones, but cavitation stresses become comparable in small stone pieces. Surface cracks accelerated fragmentation when created near the location where the maximum stress was predicted.
Dynamic spin injection into chemical vapor deposited graphene (2012)

We demonstrate dynamic spin injection into chemical vapor deposition (CVD) grown graphene by spin pumping from permalloy (Py) layers. Ferromagnetic resonance measurements at room temperature reveal a strong enhancement of the Gilbert damping at the Py/graphene interface, indeed exceeding that observed in Py/platinum interfaces. Similar results are also shown on Co/graphene layers. This enhancement in the Gilbert damping is understood as the consequence of spin pumping at the interface driven by magnetization dynamics. Our observations suggest a strong enhancement of spin-orbit coupling in CVD graphene, in agreement with earlier spin valve measurements.