gebhart/patrepeval huggingface dataset:
Cardiac chloroma: novel presentation and subsequent diagnosis with cardiac magnetic resonance imaging. (2010)

A 56-year-old man was admitted to the hospital with severe chest pain and tachycardia. He had recently begun chemotherapy for acute myelogenous leukemia. Electrocardiography showed ST-segment elevation in leads II, III, and aVF and changes in the lateral leads consistent with an inferior-wall myocardial infarction (MI) (Fig. 1). Catheterization revealed nonobstructive coronary disease without acute thrombus (Fig. 2). Cardiac magnetic resonance imaging showed an epicardial infiltrate with a noncoronary distribution in the mid-inferior wall and septum, with normal wall motion (Fig. 3). The endocardium was not involved.



Fig. 1 Electrocardiogram shows 2- to 3-mm ST-segment elevations in leads II, III, and aVF and reciprocal changes (ST-segment depression) in the lateral leads, most prominently V1 and aVL.





Fig. 2 Angiograms obtained during left-sided heart catheterization reveal nonobstructive coronary artery disease, with 30% ostial narrowing of the left main coronary artery (LM) and 40% narrowing of the left anterior descending coronary ...





Fig. 3 Delayed enhanced cardiac magnetic resonance image shows a focal, patchy, epicardial infiltrative process (arrow) that affects the mid-inferior wall and extends into the inferoseptum in the double oblique, short-axis orientation.



Medical therapy was initiated for acute coronary syndrome, and the chest pain soon subsided. Computed tomography showed no pulmonary embolus. Cardiac enzyme levels normalized within 1 week, and cardiac medications were gradually discontinued. Follow-up echocardiography revealed a left ventricular ejection fraction of 0.60 with no wall-motion abnormality or identifiable abnormality in the echographic appearance of the inferior myocardium.

Given the patient's frailty and hemodynamic stability, no further invasive testing was done. His leukemia was resistant to standard chemotherapy. Consequent to more aggressive treatment regimens, he died of multiple infections.
Construction, Expression, and Characterization of Anticarcinoma sFv Fused to IL-2 or GM-CSF (1999)

Local production of cytokines by genetically engineered tumor cells decreases their tumorigenicity and elicits protective immune responses against the parental tumor cells. An alternative approach to elicit a therapeutic immune response is to use fusion proteins that can target tumor cells and simultaneously activate effector cells. Fusion proteins between human IL-2, murine or human GM-CSF, and sFv of antihuman carcinoma antibody L6 have been constructed, expressed in both COS and Chinese hamster ovary (CHO) cells, and purified by affinity chromatography. The biologic activity of L6 sFV-hIL-2, L6 sFv-mGM-CSF, and L6 sFv-hGM-CSF was tested on human T cell blasts, factor-dependent FDCP-1, and TF-1 cells, respectively. The ability of soluble L6 sFv-hIL-2, L6 sFv-mGM-CSF, and L6 sFv-hGM-CSF to stimulate the proliferation of the indicator cells was found to be comparable to that of recombinant hIL-2, mGM-CSF, or hGM-CSF. Tumor cells coated with L6 sFV-mGM-CSF or L6 sFv-hGM-CSF were also tested in this way and were found to be potent stimulators, indicating that the cytokines were functionally active when bound to the tumor cell surface. This work demonstrates the feasibility of targeting sFv-cytokine fusion proteins for the activation of effector cells as an alternative to cytokine gene therapy.
Two-photon excited intramolecular energy transfer and light-harvesting effect in novel dendritic systems (2003)

Two-photon absorption excited intramolecular energy transfer and light-harvesting effects are demonstrated in three novel dendritic systems. These systems contain both an antenna structure that can effectively absorb two-photon energy at approximately 800 nm and emit fluorescence at approximately 515 nm and a core moiety that can absorb one-photon energy at approximately 520 nm and emit at approximately 590 nm. Covalently combining the core and antenna functionalities intrinsically changes the optical behavior of the component pieces. The two-photon energy absorbed by the antenna structure is resonantly transferred to the core, where the core's emission intensity is enhanced by 8, 20, and 34 times for the three dendritic systems.
Skin Prick Test Extracts for Dog Allergy Diagnosis Show Considerable Variations Regarding the Content of Major and Minor Dog Allergens (2010)

The observed variability of commercial dog SPT extracts regarding their allergen contents likely has a negative influence on the accuracy of diagnosis of dog allergy.
Coxsackievirus-B4 Infection Can Induce the Expression of Human Endogenous Retrovirus W in Primary Cells (2020)

Human Endogenous Retrovirus W Envelope (HERV-W ENV) mRNA or protein can be found in peripheral blood mononuclear cells (PBMCs) and exocrine pancreas of patients with type 1 diabetes (T1D). Further, previous observations have shown an association between enteroviral infection and development of T1D; specifically, coxsackievirus-B (CV-B) has been detected in the blood and pancreas of patients with T1D. Notably, viruses can activate HERV-W expression. Hence, we evaluated the effect of CV-B4 infection on HERV-W <i>ENV</i> mRNA expression. Primary human pancreatic ductal cells were obtained from five brain-dead donors. In the pancreatic cells of three donors, the HERV-W <i>ENV</i> mRNA level measured using RT-qPCR was upregulated upon CV-B4 infection. The HERV-W ENV protein was detected in the infected cells using the immunoblot assay. In human PBMCs inoculated with CV-B4 or when CV-B4 was incubated with an enhancing serum, the HERV-W <i>ENV</i> mRNA level was higher than the background RNA level. In monocyte-derived macrophages obtained from 5 of 13 donors, the HERV-W <i>ENV</i> mRNA level was higher in cultures inoculated with CV-B4 than in the control. Therefore, CV-B4 can upregulate or induce the transcription of a certain HERV-W <i>ENV</i> copy (or copies) in primary cell cultures, such as monocytes, macrophages, and pancreatic cells.
Investigation on temperature sensitivity of D-shaped fibers by manufacturing specified surface structure (2009)

Temperature sensitivities of D-shaped fibers with specified surface structures such as thin film and periodic grating are investigated. The photo resister overlay can induce the evanescent field coupling of the core mode to the cladding mode in the overlay. The mode coupling can be modified by the overlay structures such as a single layer and periodic grating. The temperature sensitivity of D-shaped fibers with versatile overlay structures is also changed.
Cochlear reimplantation in device failure: effectiveness and safety (2004)

Iwasaki S, Atsumi K, Ocho S, Mizuta K (1998) Facial nerve stimulation by a cochlear implant in a hemodialysis patient with bone of low mineral density. European Archives of Otorhinolaryngology 225: 352–354. Muckle RP, Levine SC (1994) Facial nerve stimulation produced by cochlear implants in patients with cochlear otosclerosis. American Journal of Otology 15(3): 394–398. Valvassori GE, Dobben GD (1985) CT densitometry of the cochlear capsule in otosclerosis. American Journal of Neuroradiology 6: 661–667. Weber BP, Lenarz T, Battmer RD, Hartrampf R, Dahm MC, Dietrich B (1995) Otosclerosis and facial nerve stimulation. Annals of Otology Rhinology and Laryngology Suppl. 166: 445–447.
Leaking light through embedded shifter-type opaque ring for attenuated phase-shift mask (1997)

Critical dimension error on a wafer caused by leaking light through embedded shifter type opaque ring on an i-line attenuated phase-shift mask has been studied. We have produced the mask that includes small pinhole-array pattern as the opaque ring, and confirm that transmittance through the opaque ring depends on pinhole size in good agreement with coherent theory. Our experimental result shows that the leakage must be less than 0.125% in transmittance in order to control resist dimension error less than 0.01 micrometer on a wafer for 0.35 - 0.4 micrometer devices. We have also derived an analytical form to represent leaking light, which shows good fit to the transmittance measurements with the various pinhole size. Then we have estimated the allowable error in phase difference and transmittance of the shifter, and that in pinhole size, applying for this formula. We also discuss the process feasibility for embedded shifter type opaque ring.
First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway (2015)

This article documents the discovery of BLU9931, a novel irreversible kinase inhibitor that specifically targets FGFR4 while sparing all other FGFR paralogs and demonstrates exquisite kinome selectivity. BLU9931 is efficacious in tumors with an intact FGFR4 signaling pathway that includes FGF19, FGFR4, and KLB. BLU9931 is the first FGFR4-selective molecule for the treatment of patients with HCC with aberrant FGFR4 signaling.
Novel Electro-Deoxygenation Process for Bio-oil Upgrading (2018)

Biomass is a potential source of renewable fuel. Bio-oil produced by fast pyrolysis is a prospective option to replace fossil fuels for transportation. However, bio-oil needs to be upgraded to remove its high oxygen and water content, and acidity to produce useful fuels. The upgrading of bio-oil is generally accomplished by hydrodeoxygenation (HDO) using hydrogen. The instability of bio-oil poses a major challenge in transportation to central upgrading facility. An electro-deoxygenation (EDOx) process was evaluated to fully or partially deoxygenate bio-oil using solid oxide electrolysis process. This device uses an oxygen ion conducting membrane which under an applied electric potential removes oxygen in the form of an ion and transports it to the opposite side of the membrane where it is released as oxygen molecule. When water is present in the bio-oil vapor, the process generates in situ hydrogen to facilitate deoxygenation over the electrode that functions as catalyst.
Sensory Characteristics of Threadfin Bream (Nemipterus japonicus) Hydrolysate (2005)

ABSTRACT Threadfin bream (Nemipterus japonicus) spray-dried hydro-lysate was prepared using Alcalase at predetermined optimum hydrolysis conditions consisting of pH 8.5, 60°C, 2% enzyme, and 2 h hydrolysis. The hydrolysate was evaluated for its preferred concentration in rice porridge. Its acceptability was compared with sauces and enzyme-treated rice and vegetable hydrolysate. The preferred concentration in rice porridge was found to be 3% (w/v) and bitterness increased with concentration of hydrolysate. Threadfin bream hydrolysate was preferred as much as soy sauce; however, it received a lower score for taste compared to fish sauce. In terms of color, threadfin bream hydrolysate received significantly (p < 0.05) lower score than Flavorzyme and Alcalase treated rice hydrolysate and Vegetable hydrolysate. Low preference to the hydrolysate could probably be due to its greenish yellow color in which the common color for flavorants are brownish. For overall acceptability, no significant difference was observed between threadfin bream hydrolysate and Alcalase-treated rice hydrolysate but was significantly lower than vegetable hydrolysate and Flavorzyme-treated rice hydrolysate. The hydrolysis of threadfin bream with Alcalase produced hydrolysate having a combination of bitter, umami, salty, sweet and sour tastes with fishy flavor. Bitterness and umami were rated as having an intermediate intensity, salty as between weak and intermediate, and sour and sweet as weak. The three basic tastes for hydrolysate were bitter, umami and salty, with umami and bitterness being the determining tastes.
The internet of things for healthcare: optimising e-health system availability in the fog and cloud (2020)

E-health systems can be used to monitor people in real-time, offering a range of multimedia-based health services, at the same time reducing the cost since cheaper devices can be used to compose it. However, any downtime, mainly in the case of critical health services, can result in patient health problems and in the worst case, loss of life. In this paper, we use an interdisciplinary approach combining stochastic models with optimisation algorithms to analyse how failures impact e-health monitoring system availability. We propose surrogate models to estimate the availability of e-health monitoring systems that rely on edge, fog, and cloud infrastructures. Then, we apply a multi-objective optimisation algorithm, NSGA-II, to improve system availability considering component costs as constraint. Results suggest that replacing components with more reliable ones is more effective in improving the availability of an e-health monitoring system than adding more redundant components.
Primary human immune response to dendritic cell inoculation in humanized mice (2008)

Models for investigating the use of human dendritic cells (DC) in active immunotherapy are limited. Humanized (Hu) NOD/SCID mice were evaluated for their capacity to respond to injected allogenic DCs. Hu‐mice were generated by implanting human fetal thymus and liver under the kidney capsule, followed 3 weeks later by injection of autologous CD34+ cells. Flow cytometry analysis for human cells in peripheral blood of n=11 mice at 4 months showed: 59+13% CD45+ cells, 83+2% T cells, 9% B cells, and 2% myeloid cells. Human cells were present in bone marrow, 16+7%, spleen, 30+6%, and lymph nodes 2+0.4%. T and B cells were organized in germinal centre‐like structures in the spleen. Mice were inoculated intravenously with luciferase gene marked human, allogenic DCs to localize migration patterns and evaluate immune responses. Bioluminescence imaging showed DCs throughout mice and in organs. Stimulation of spleen cells from DC inoculated mice, in vitro, with matched autologous or allogenic DCs, showed proliferation of CD8+ T cells to only the Hu‐mouse allogenic cells used for injection. CD8+ T cells expressed the perforin degranulation marker, CD107a, and half of these cells were positive for intracellular IFNr, indicating acquired cytotoxic function. Studies are underway to assess responses to CMV antigens. Hu‐mice may be useful for investigating primary immune responses to vaccines. Supported by DARPA W81XWH‐04‐C0139
Laser photoelectron spectroscopy of the formyl anion (1986)

The 488 nm photoelectron spectra of HCO− and DCO− show vibrational structure in the X̃ 2A′ state of neutral formyl radical up to 10 000 cm−1 above the vibrational ground state. Electron affinities are found to be 0.313±0.005 eV for HCO and 0.301±0.005 eV for DCO. The CH bond strength and heat of formation of HCO− and the gas phase acidity of formaldehyde are derived from these data. A Franck–Condon analysis of the photoelectron spectra provides an estimate of the equilibrium geometry of the anion. Transitions to excited vibrational states of HCO enable the determination of a complete set of quadratic anharmonicities.
Glucocorticoids Prolong Rat Sciatic Nerve Blockade In Vivo from Bupivacaine Microspheres (1996)

Glucocorticoids prolong blockade from bupivacaine microspheres. The mechanism appears unrelated to the kinetics of bupivacaine release in vivo.
Safety and efficacy of fistula closure by endoscopic suturing: a multi-center study (2016)

<b>Background and aim:</b> Endoscopic closure of fistulas is desirable but remains a challenge, especially for gastrogastric fistulas. The aim of this study was to assess the success rate for the closure of gastrointestinal fistulas using an endoscopic suturing device. <b>Patients and methods:</b> Electronic records at three medical centers were reviewed to identify patients who underwent sutured fistula closure as recorded on a central database. Demographic details, clinical variables, and details of the endoscopic procedure were recorded. <b>Results:</b> A total of 56 patients (mean age 54 ± 12.7 years) underwent fistula closure. Gastrogastric fistulas were most common (n = 29; 51.8 %). Sixteen patients (28.6 %) had undergone previous failed attempts at closure. Immediate success was universal (n = 56; 100 %). Thirteen patients had persistent closure without any need for further therapies, while 17 underwent additional endoscopic procedures, with successful closure in 4 /17. Only one patient had abdominal pain requiring hospital admission. <b>Conclusion:</b> Sutured closure of fistulas in a single session is safe and can be expected, even in what are known to be challenging cases. Sequential closure for recurrences is sometimes successful in the longer term.
Supplementary Figures 1-3 from Inhibition of Glycogen Synthase Kinase 3β Attenuates Neurocognitive Dysfunction Resulting from Cranial Irradiation (2023)

Supplementary Figures 1-3 from Inhibition of Glycogen Synthase Kinase 3β Attenuates Neurocognitive Dysfunction Resulting from Cranial Irradiation
A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate (2015)

Although G protein-coupled receptor (GPCR) internalization has long been considered as a major aspect of the desensitization process that tunes ligand responsiveness, internalization is also involved in receptor resensitization and signaling, as well as the ligand scavenging function of some atypical receptors. Internalization thus contributes to the diversity of GPCR-dependent signaling, and its dynamics and quantification in living cells has generated considerable interest. We developed a robust and sensitive assay to follow and quantify ligand-induced and constitutive-induced GPCR internalization but also receptor recycling in living cells. This assay is based on diffusion-enhanced resonance energy transfer (DERET) between cell surface GPCRs labeled with a luminescent terbium cryptate donor and a fluorescein acceptor present in the culture medium. GPCR internalization results in a quantifiable reduction of energy transfer. This method yields a high signal-to-noise ratio due to time-resolved measurements. For various GPCRs belonging to different classes, we demonstrated that constitutive and ligand-induced internalization could be monitored as a function of time and ligand concentration, thus allowing accurate quantitative determination of kinetics of receptor internalization but also half-maximal effective or inhibitory concentrations of compounds. In addition to its selectivity and sensitivity, we provided evidence that DERET-based internalization assay is particularly suitable for characterizing biased ligands. Furthermore, the determination of a Z'-factor value of 0.45 indicates the quality and suitability of DERET-based internalization assay for high-throughput screening (HTS) of compounds that may modulate GPCRs internalization.
GPU-Accelerated Asynchronous Error Correction for Mixed Precision Iterative Refinement (2011)

In hardware-aware high performance computing, block-asynchronous iteration and mixed precision iterative refinement are two techniques that may be used to leverage the computing power of SIMD accelerators like GPUs in the iterative solution of linear equation systems. although they use a very different approach for this purpose, they share the basic idea of compensating the convergence properties of an inferior numerical algorithm by a more efficient usage of the provided computing power. In this paper, we analyze the potential of combining both techniques. Therefore, we derive a mixed precision iterative refinement algorithm using a block-asynchronous iteration as an error correction solver, and compare its performance with a pure implementation of a block-asynchronous iteration and an iterative refinement method using double precision for the error correction solver. For matrices from the University of Florida Matrix collection, we report the convergence behaviour and provide the total solver runtime using different GPU architectures.
Low dissipation spectral filtering using a field-effect tunable III–V hybrid metasurface (2018)

Considering the power constrained scaling of silicon complementary metal-oxide-semiconductor technology, the use of high mobility III–V compound semiconductors such as In0.53Ga0.47As in conjunction with high-κ dielectrics is becoming a promising option for future n-type metal-oxide-semiconductor field-effect-transistors. Development of low dissipation field-effect tunable III–V based photonic devices integrated with high-κ dielectrics is therefore very appealing from a technological perspective. In this work, we present an experimental realization of a monolithically integrable, field-effect-tunable, III–V hybrid metasurface operating at long-wave-infrared spectral bands. Our device relies on strong light-matter coupling between epsilon-near-zero (ENZ) modes of an ultra-thin In0.53Ga0.47As layer and the dipole resonances of a complementary plasmonic metasurface. The tuning mechanism of our device is based on field-effect modulation, where we modulate the coupling between the ENZ mode and the metasurface by modifying the carrier density in the ENZ layer using an external bias voltage. Modulating the bias voltage between ±2 V, we deplete and accumulate carriers in the ENZ layer, which result in spectrally tuning the eigenfrequency of the upper polariton branch at 13 μm by 480 nm and modulating the reflectance by 15%, all with leakage current densities less than 1 μA/cm2. Our wavelength scalable approach demonstrates the possibility of designing on-chip voltage-tunable filters compatible with III–V based focal plane arrays at mid- and long-wave-infrared wavelengths.
Upper limit map of a background of gravitational waves (2007)

We searched for an anisotropic background of gravitational waves usingdata from the LIGO S4 science run and a method that is optimizedfor point sources. This is appropriate if, for example, the gravitationalwave background is dominated by a small number of distinct astrophysical sources.No signal was seen. Upper limit maps were produced assuming two differentpower laws for the source strain power spectrum. For an ${f}^{\ensuremath{-}3}$ power law and using the50 Hz to 1.8 kHz band the upper limits on the sourcestrain power spectrum vary between $1.2\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}48}\text{ }\text{ }{\mathrm{Hz}}^{\ensuremath{-}1}$ $(100\text{ }\text{ }\mathrm{Hz}/f{)}^{3}$ and $1.2\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}47}\text{ }\text{ }{\mathrm{Hz}}^{\ensuremath{-}1}$ $(100\text{ }\text{ }\mathrm{Hz}/f{)}^{3}$, depending on the position in the sky. Similarly,in the case of constant strain power spectrum, the upper limits vary between $8.5\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}49}\text{ }\text{ }{\mathrm{Hz}}^{\ensuremath{-}1}$ and $6.1\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}48}\text{ }\text{ }{\mathrm{Hz}}^{\ensuremath{-}1}$. As a side product a limiton an isotropic background of gravitational waves was also obtained. All limitsare at the 90% confidence level. Finally, as an application, we focused onthe direction of Sco-X1, the brightest low-mass x-ray binary. We compare theupper limit on strain amplitude obtained by this method to expectations basedon the x-ray flux from Sco-X1.