gebhart/patrepeval huggingface dataset:
Chemical Stability of Porous Silicon Surfaces Electrochemically Modified with Functional Alkyl Species (2003)

The chemical stability of electrochemically alkylated porous silicon is studied. The hydride-terminated surface of p-type or p++-type porous silicon is stabilized by electrochemical reduction of organohalides in acetonitrile solutions. Reduction of 6-iodo-ethylhexanoate, 1-iodo-6-(trifluoroacetylamino)hexane, iodomethane, 1-bromohexane, or ethyl 4-bromobutyrate at a porous Si cathode results in removal of the halogen and attachment of the organic fragment to the porous Si surface via a Si−C bond. A two-step procedure involving attachment of the functional group of interest followed by attachment of methyl groups (by reduction of iodomethane) to residual, more sterically inaccessible sites on the porous Si surface is found to yield a more stable material. Three tests of the chemical stability of the modified surfaces are performed: treatment with dimethyl sulfoxide (a chemical oxidant for porous Si), treatment with aqueous Cu2+, and exposure to 10% ethanol in a solution of phosphate buffered (pH = 7.4) aqueous saline. The reactions are characterized by atomic force microscopy, Fourier transform infrared (FT-IR) and optical reflectivity spectroscopies. The data indicate that electrochemical alkylation greatly improves the stability of porous Si against oxidation and corrosion, and that the methyl capping procedure provides the most stable material.
50Gb/s Silicon Photonics Platform for Short-Reach Optical Interconnects (2016)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. Pantouvaki, P. De Heyn, M. Rakowski, P. Verheyen, B. Snyder, S. A. Srinivasan, H. Chen, J. De Coster, G. Lepage, P. Absil, and J. Van Campenhout, "50Gb/s Silicon Photonics Platform for Short-Reach Optical Interconnects," in Optical Fiber Communication Conference, OSA Technical Digest (online) (Optica Publishing Group, 2016), paper Th4H.4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Aberrant expression of GOLM1 protects ALK+ anaplastic large cell lymphoma from apoptosis by enhancing BCL-XL stability (2023)

Golgi membrane protein 1 (GOLM1) is aberrantly expressed in many types of solid tumors and contributes to cancer development; however, its role in hematopoietic and lymphoid neoplasms remains unknown. Here, we report that GOLM1 was significantly upregulated in anaplastic large cell lymphoma (ALCL), particularly in anaplastic lymphoma kinase-positive (ALK+) ALCL. Mechanistically, the expression of GOLM1 was induced by nucleophosmin-ALK in both ALK-transformed T cells and ALCL cell lines through AKT/mTOR pathway. Knockdown of GOLM1 expression led to a reduction in the growth and viability of ALCL cells with increased spontaneous apoptosis, whereas ectopic expression of GOLM1 protected ALCL cells from apoptosis induced by staurosporine treatment. Moreover, GOLM1 directly interacted with B-cell lymphoma-extra large protein (a crucial anti-apoptosis regulator) and significantly prolonged its stability. Introduction of GOLM1 promoted ALK+ ALCL cells colony formation in vitro and tumor growth in a murine xenograft model. Taken together, our findings demonstrate, to our knowledge, for the first time that GOLM1 plays a critical role in suppressing apoptosis and promoting the progression of ALK+ ALCL and provide evidence that GOLM1 is a potential biomarker and therapeutic target in ALK-induced hematological malignancies.
Near-Visible Microresonator-Based Soliton Combs (2019)

We experimentally demonstrate soliton mode-locked Kerr comb generation at near-visible wavelengths in a silicon nitride microresonator. We achieve the shortest wavelength to-date for mode-locked Kerr combs through dispersion engineering of a higher-order mode.
Comparing two functional programming systems (1989)

A technique is presented for comparing the performance of functional languages with different evaluation strategies running on different machines. A set of small benchmarks is used, and th execution times of these programs running in the functional language and in the implementation language of the functional system are compared. The ratio of these execution times measured how well the functional system used the resources of the underlying hardware and implementation language. Also two functional programming systems are described. One system is a graph reduction interpreter for lambda calculus. The other is a DEL-style intermediate instruction set architecture for FP. The benchmarks in FP and the performances of the two systems on these benchmarks are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Performance Impacts of Analog ReRAM Non-ideality on Neuromorphic Computing (2019)

Resistive random access memory (ReRAM) is often considered as a strong candidate for storing the weights in non-von Neumann neuromorphic computing systems. This paper studies how nonideal memory characteristics, which include programing error, read fluctuation, and retention, affect the inference accuracy of the analog ReRAM neural networks by incorporating memory characteristics extracted from 1-Mb ReRAM into a simulated inference-only neural network. This paper also shows that the different layer in the network can tolerate different amount of such imperfects. We learned four key points: 1) the conductance range of memory with less relative fluctuation is preferred for designing the weight-conductance mapping; 2) the control of programing error is essential for high inference accuracy; 3) retention-induced conductance drift can be fatal to the neuromorphic system. A compensation scheme is proposed in this paper which can effectively recover the inference accuracy; and 4) for multilayer networks, avoiding weight errors in the front layers can help to maintain the inference accuracy by reducing calculation error which may otherwise accumulate and pass down the networks. The concepts and approaches of this paper can also be applied to evaluate other types of nonvolatile memories for artificial neural networks.
Methamphetamine-Associated Psychosis (2011)

Methamphetamine (METH) is a frequent drug of abuse in U.S. populations and commonly associated with psychosis. This may be a factor in frequent criminal justice referrals and lengthy treatment required by METH users. Persecutory delusions and auditory hallucinations are the most consistent symptoms of METH-associated psychosis (MAP). MAP has largely been studied in Asian populations and risk factors have varied across studies. Duration, frequency and amount of use as well as sexual abuse, family history, other substance use, and co-occurring personality and mood disorders are risk factors for MAP. MAP may be unique with its long duration of psychosis and recurrence without relapse to METH. Seven candidate genes have been identified that may be associated with MAP. Six of these genes are also associated with susceptibility, symptoms, or treatment of schizophrenia and most are linked to glutamatergic neurotransmission. Animal studies of pre-pulse inhibition, attenuation of social interaction, and stereotypy and alterations in locomotion are used to study MAP in rodents. Employing various models, rodent studies have identified neuroanatomical and neurochemical changes associated with METH use. Throughout this review, we identify key gaps in our understanding of MAP and suggest potential directions for future research.
Hormonally Mediated Negative Regulation of Human Pro-Opiomelanocortin Gene Expression after Transfection into Mouse L Cells (1985)

We report results indicating that expression and hormonally controlled negative regulation of the human pro-opiomelanocortin (POMC) gene in mouse fibroblasts can be accomplished by the placement nearby of a simian virus 40 enhancer sequence. Expression resulting from correctly initiated transcription required the enhancer in cis both in cells stably transfected with the POMC gene and in a transient expression assay with constructs that fused that POMC promoter region to the protein-coding region of the herpes simplex virus thymidine kinase (TK) gene. Negative regulation of POMC transcription by glucocorticoids was demonstrated in transiently infected cells by assaying for TK activity encoded by the POMC-TK fusion constructs and by quantitative S1 nuclease mapping. The sequences responsible for such regulation were shown to be contained within a DNA segment that extends 670 base pairs upstream from the cap site for POMC mRNA.
Preparation of Ethyl 5‐Iodo‐1H‐indole‐2‐carboxylate. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Abstract C146: In human lung carcinoma cells that contain estrogen receptor-α(ER), thyroid hormone-induced proliferation initiated at an integrin requires ER. (2011)

Abstract We examined the molecular basis of thyroid hormone-induced proliferation of two estrogen receptor-α (ER)-expressing human lung cancer cell lines, non-small cell carcinoma NCI-H522 and small cell carcinoma NCI-H510A. At a physiologic total L-thyroxine (T4) concentration (10[−7] M) and supraphysiologic 3,5,3'-triiodo-L-thyronine (T3) levels, thyroid hormone significantly increased proliferating cell nuclear antigen (PCNA) content of both cell lines. Neutralizing antibody to integrin αvβ3 and integrin-binding Arg-Gly-Asp (RGD) peptide inhibited cell proliferation stimulated by thyroid hormone. Tetraiodothyroacetic acid (tetrac) blocks binding of T4 and T3 to the hormone receptor on αvβ3 and inhibited thyroid hormone-induced cancer cell proliferation. Thus, the thyroid hormone effect is initiated nongenomically at the cell surface thyroid hormone receptor we have described on integrin αvβ3. The thyroid hormone isoforms also caused serine phosphorylation of ER in NCI-H522 and NCI-H510A cells. The ER antagonist, ICI 182,780 (fulvestrant) inhibited stimulation by T4 and T3 of ER phosphorylation, of PCNA accumulation and of radiolabeled thymidine incorporation by the cells. These results are consistent with existence of crosstalk between the plasma membrane receptor for iodothyronines and ER in these lung cancer cells. We conclude that endogenous T4 is a growth factor for ER-containing lung cancer cells and this hormonal action is subject to inhibition by tetrac and by fulvestrant. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2011 Nov 12-16; San Francisco, CA. Philadelphia (PA): AACR; Mol Cancer Ther 2011;10(11 Suppl):Abstract nr C146.
An Imperceptible Magnetic Skin (2019)

Abstract Flexible and wearable magnetoelectronics add intriguing new functionalities to natural perception. Of particular interest regarding these artificial skins are wireless sensing and touchless interactions. Biocompatibility and imperceptibility are the most significant features of devices attached to the bodies. A biocompatible magnetic skin is introduced. It offers extreme flexibility, stretchability (&gt;300%), and is lightweight, while maintaining a remanent magnetization up to 360 mT. It is comfortable to wear, can be realized in any desired shape or color, and adds tunable permanent magnetic properties to the surface it is applied to. It provides remote control functions and is combined with magnetic sensors; it implements a complete wearable magnetic system. For example, eye tracking is realized by attaching the magnetic skin to the eyelid. The advantage that it does not require any wiring makes it an extremely viable solution for soft robotics and human–machine interactions. Wearing the magnetic skin on a finger or integrated into a glove allows for remote gesture control. This type of application opens the door to new control concepts, relevant for people with disabilities, sterile environments, or the consumer industry.
Taking Denitrification to the Next Level: An Upgrade of Proven Technology With 21st Century I&C (2013)

In 2006, one of the largest wastewater reclamation facilities in the northern Virginia area recognized the need to expand the facility from 18 to 24 mgd (million gallons per day). In part, the upgrade was triggered by regulations requiring reduction of Total Nitrogen discharge on an annual basis to 3 mg/L. At the same time, there was a need to replace their plant-wide data acquisition and control system (DACS), with a new modern supervisory control and data acquisition (SCADA) system. This design-build project also provided “limit of technology” nutrient removal; the existing aeration basin volume was doubled and reconfigured to allow operation in either 4-stage Bardenpho or modified ludzack ettinger (MLE) modes; 14 new de-nitrification filters were implemented for a total of 24; and a second/standby chemical analyzer was installed for redundancy purposes. Furthermore, methanol feed was automated to be flow paced and controlled by a proprietary software calculation algorithm. The proprietary software calculation algorithm for control is feed-forward/feed-back based upon flow and influent and effluent nitrate concentrations. This enhanced the operation and reliability of the process and also reduced the risk of methanol overdose by more closely matching the methanol to feed demand. Consistent methanol dose control is challenging when trying to meet low effluent total nitrogen while simultaneously maintaining a low Carbonaceous Biochemical Oxygen Demand (CBOD). This plant is currently in full operation, being controlled by plant staff, and in compliance with the regulation requirements that triggered the plant-wide upgrade in the first place. This paper will discuss the integration of new technologies, the operational benefits, and the startup coordination required to reliably meet the new operating permit limits.
Advanced Model for Fast Assessment of Piezoelectric Micro Energy Harvesters (2016)

The purpose of this work is to present recent advances in modelling and design of piezoelectric energy harvesters, in the framework of Micro-Electro-Mechanical Systems (MEMS). More specifically, the case of inertial energy harvesting is considered, in the sense that the kinetic energy due to environmental vibration is transformed into electrical energy by means of piezoelectric transduction. The execution of numerical analyses is greatly important in order to predict the actual behaviour of MEMS devices and to carry out the optimization process. In the common practice, the results are obtained by means of burdensome 3D Finite Element Analyses (FEA). The case of beams could be treated by applying 1D models, which can enormously reduce the computational burden with obvious benefits in the case of repeated analyses. Unfortunately, the presence of piezoelectric coupling may entail some serious issues in view of its intrinsically three-dimensional behaviour. In this paper, a refined, yet simple, model is proposed with the objective of retaining the Euler-Bernoulli beam model, with the inclusion of effects connected to the actual three-dimensional shape of the device. The proposed model is adopted to evaluate the performances of realistic harvesters, both in the case of harmonic excitation and for impulsive loads.
Combining Krylov subspace methods and identification-based methods for model order reduction (2006)

Many different techniques to reduce the dimensions of a model have been proposed in the near past. Krylov subspace methods are relatively cheap, but generate non-optimal models. In this paper a combination of Krylov subspace methods and orthonormal vector fitting (OVF) is proposed. In that way a compact model for a large model can be generated. In the first step, a Krylov subspace method reduces the large model to a model of medium size, then a compact model is derived with OVF as a second step.
Alzheimer’s disease: challenges ahead (2010)

OPINION article Front. Psychiatry, 01 February 2010Sec. Neurodegeneration Volume 1 - 2010 | https://doi.org/10.3389/fpsyt.2010.00005
Fast Atom Bombardment Tandem Mass Spectrometry of Carotenoids (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFast Atom Bombardment Tandem Mass Spectrometry of CarotenoidsRichard B. van Breemen, Harold H. Schmitz, and Steven J. SchwartzCite this: J. Agric. Food Chem. 1995, 43, 2, 384–389Publication Date (Print):February 1, 1995Publication History Published online1 May 2002Published inissue 1 February 1995https://pubs.acs.org/doi/10.1021/jf00050a024https://doi.org/10.1021/jf00050a024research-articleACS PublicationsRequest reuse permissionsArticle Views358Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Leukocyte- and Platelet-Rich Fibrin (L-PRF) for Long-Term Delivery of Growth Factor in Rotator Cuff Repair: Review, Preliminary Results and Future Directions (2012)

Surgical repair of the rotator cuff repair is one of the most common procedures in orthopedic surgery. Despite it being the focus of much research, the physiological tendon-bone insertion is not recreated following repair and there is an anatomic non-healing rate of up to 94%. During the healing phase, several growth factors are upregulated that induce cellular proliferation and matrix deposition. Subsequently, this provisional matrix is replaced by the definitive matrix. Leukocyte- and platelet-rich fibrin (L-PRF) contain growth factors and has a stable dense fibrin matrix. Therefore, use of LPRF in rotator cuff repair is theoretically attractive. The aim of the present study was to determine 1) the optimal protocol to achieve the highest leukocyte content; 2) whether L-PRF releases growth factors in a sustained manner over 28 days; 3) whether standard/gelatinous or dry/compressed matrix preparation methods result in higher growth factor concentrations. 1) The standard L-PRF centrifugation protocol with 400 x g showed the highest concentration of platelets and leukocytes. 2) The L-PRF clots cultured in medium showed a continuous slow release with an increase in the absolute release of growth factors TGF-β1, VEGF and MPO in the first 7 days, and for IGF1, PDGF-AB and platelet activity (PF4=CXCL4) in the first 8 hours, followed by a decrease to close to zero at 28 days. Significantly higher levels of growth factor were expressed relative to the control values of normal blood at each culture time point. 3) Except for MPO and the TGFβ-1, there was always a tendency towards higher release of growth factors (i.e., CXCL4, IGF-1, PDGF-AB, and VEGF) in the standard/gelatinous- compared to the dry/compressed group. L-PRF in its optimal standard/gelatinous-type matrix can store and deliver locally specific healing growth factors for up to 28 days and may be a useful adjunct in rotator cuff repair.
Fault - tolerant design of the IBM POWER6™ microprocessor (2007)

This article consists of a collection of slides from the author's conference presentation on IBM's Power6 microprocessor. Some of the specific topics discussed include: the special features, architecture and system design of Power6; system core and processing capabilities; new RAS features; the validation of resilience with proton beam accelerated testing facilities; and future areas of product improvement.
Effect of Barbiturates on Oxidative Phosphorylation. (1951)

It has been shown that thiopental, pentobarbital and amobarbital lower the phosphate : oxygen uptake ratio obtained in particulate tissue preparations from liver and brain respiring on a pyruvate substrate. This depression is obtained at concentrations of the drugs which have only a slight effect on the oxygen uptake of the preparations and which approximate those which are necessary in vivo to produce surgical anesthesia. It is postulated that such an uncoupling of phosphorylation from oxidation may be one of the ways in which barbiturates act to produce anesthesia.
Demonstration of novel spectrum-efficient elastic optical path network with per-channel variable capacity of 40 Gb/s to over 400 Gb/s (2008)

We demonstrated, for the first time, a novel spectrum-efficient elastic optical path network for 100 Gb/s services and beyond, based on flexible rate transceivers and variable-bandwidth wavelength crossconnects.
Outsourced hearing in an orb-weaving spider that uses its web as an auditory sensor (2022)

SignificanceThe sense of hearing in all known animals relies on possessing auditory organs that are made up of cellular tissues and constrained by body sizes. We show that hearing in the orb-weaving spider is functionally outsourced to its extended phenotype, the proteinaceous self-manufactured web, and hence processes behavioral controllability. This finding opens new perspectives on animal extended cognition and hearing-the outsourcing and supersizing of auditory function in spiders. This study calls for reinvestigation of the remarkable evolutionary ecology and sensory ecology in spiders-one of the oldest land animals. The sensory modality of outsourced hearing provides a unique model for studying extended and regenerative sensing and presents new design features for inspiring novel acoustic flow detectors.
ChemInform Abstract: Efficient Synthesis of Monoacyl Dipyrromethanes and Their Use in the Preparation of Sterically Unhindered trans‐Porphyrins. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.