gebhart/patrepeval huggingface dataset:
Chronic lymphocytic leukaemia patients have a high risk of Merkel-cell polyomavirus DNA-positive Merkel-cell carcinoma (2009)

We conclude that patients diagnosed with CLL have a substantially increased risk for MCC, and vice versa. Merkel-cell polyomavirus DNA is frequently present in MCCs that occur in CLL patients. Immunosuppression related with CLL and viral infection might explain the association between CLL and MCC.
<title>Comparison Of Digital Subtraction Video Densitometry And Area Length Method In The Determination Of Left Ventricular Ejection Fraction</title> (1981)

Digital subtraction video densitometry is utilized in the determination of left ventricular ejection fraction. The mask mode subtracted video images obtained after a peripheral intravenous injection of a bolus of Renografin 76 are used in the derivation of a density time curve. The left ventricular ejection fraction (LVEF) is computed by an algorithm described in this paper. Results for 15 patients are compared to the LVEF&apos;s obtained by applying the area-length method to the same patient data. The left ventricular ejection fractions computed by both methods had a good correlation (r=0.96) in fifteen patients.*
Optimization of Photon and Electron Collection Efficiencies in Silicon Solar Microcells for Use in Concentration‐Based Photovoltaic Systems (2017)

Abstract Ultrathin silicon solar microcells (μ‐cells) afford a means to reduce semiconductor material consumption and can be integrated with concentration optics to improve their power density. A μ‐cell design is described that optimizes electron and photon collection with enhanced efficiency for solar concentration applications. An interdigitated back contact (IBC) design improves carrier collection partially due to larger contact coverage while further enabling optimization of the μ‐cell front surface. To do so, a silicon nitride antireflection thin film coating is utilized to enhance photon absorption and improve surface passivation. Performance of IBC μ‐cells is compared to an optimized top contact design and improves μ‐cell conversion efficiencies from 9.9 to 13.7%. Improvements at 1 Sun are amplified under concentration and increase power densities at 20 Suns to 346 from 192 mW cm −2 due to minimized series resistance. Benefits afforded by IBC μ‐cells are exemplified following their integration into a dual concentrator system, affording photon collection capacities for direct and diffuse irradiance. A traditional lens concentrates direct light while a luminescent solar concentrator (LSC) collects diffuse photons otherwise not utilized by passive optics. Addition of the LSC increases maximum power densities on clear and cloudy days, providing concentration for the latter and further increasing the power density.
Visual Distraction: An Altered Aiming Spatial Response in Dementia (2012)

'Aiming' motor-preparatory brain activity may be induced by distraction in pAD subjects as compared to typical visual-motor function in controls.
Effects of background gas composition and pressure on 1,4-polymyrcene (and polytetrafluoroethylene) spectra in near-ambient pressure XPS (2020)

Near-ambient pressure XPS (NAP-XPS) is a less traditional form of XPS that allows samples to be analyzed at relatively high pressures, i.e., at 2500 Pa or greater. With NAP-XPS, one can analyze moderately volatile liquids, biological samples, porous materials, and/or polymeric materials that outgas significantly. In this submission, the authors show C 1s, O 1s, and survey NAP-XPS spectra from 1,4-polymyrcene. The C 1s and O 1s envelopes are fit with Gaussian–Lorentzian product, asymmetric Lorentzian, and Gaussian–Lorentzian sum functions. Water vapor and argon are used to control sample charging, and the corresponding signals from the gases are present in the survey spectra. The effect of background gas pressure on photoelectron attenuation is illustrated with a sample of polytetrafluoroethylene.
Multilayer concentrated windings for axial flux PM machines (2016)

Coreless axial flux machines with airgap concentrated windings are of interest due to their high torque density. One of the main challenges with such a winding is that the torque producing MMF component that corresponds to the fundamental of the permanent magnet excitation is accompanied by harmonics. At least one of them is of substantial amplitude. The other harmonics are asynchronous and cause losses in the rotor core and magnets. The lower order harmonics, due to their higher magnitude, are of especial harm. This paper proposes a new multilayer winding arrangement to reduce the non torque producing MMF harmonics. This winding is applied to a 12 coil 16 pole coreless axial flux machine. The efficacy of the winding is established by 3D finite element analysis.
Polymer microstructure waveguides on alumina and beryllium oxide substrates for optical inteconnection (1990)

We report the first high quality optical waveguides (loss &amp;lt;1 dB/cm) on alumina and beryllium oxide substrates. The tunability of the polymer guiding layer refractive index is provided through a recently developed wet processing technique. This procedure changes the waveguide propagation loss from larger than 40 dB/cm to less than 1 dB/cm. Since alumina (Al2O3) and beryllium oxide (BeO) are the major substrates for hybrid mode microwave integrated circuits (HMMICs), realization of such waveguides is useful for optical interconnection and signal processing for HMMIC.
Data from Depletion of the Ras Association Domain Family 1, Isoform A–Associated Novel Microtubule-Associated Protein, C19ORF5/MAP1S, Causes Mitotic Abnormalities (2023)

&lt;div&gt;Abstract&lt;p&gt;Ras association domain family 1, isoform A (RASSF1A) is a novel tumor suppressor gene that is found to be inactivated in more than 40 types of sporadic cancers. In addition, mouse Rassf1a knockout models have an increased frequency of spontaneous and induced tumors. The mechanisms by which RASSF1A exerts its tumor suppression activities or the pathways it can regulate are not yet fully understood. Using yeast two-hybrid system, we have previously identified C19ORF5/MAP1S as the major RASSF1A-interacting protein. C19ORF5 has two conserved microtubule-associated regions and may function to anchor RASSF1A to the centrosomes. In this study, we have analyzed the cellular functions of C19ORF5. By using small interfering RNA–mediated depletion and time-lapse video microscopy, we show that C19ORF5 knockdown causes mitotic abnormalities that consist of failure to form a stable metaphase plate, premature sister chromatid separation, lagging chromosomes, and multipolar spindles. We also show that a fraction of C19ORF5 localizes to the spindle microtubules. Additionally, we show here that C19ORF5 localizes to the microtubule-organizing centers during microtubule regrowth after nocodazole washout. Knockdown of C19ORF5 disrupts the microtubule-organizing center and results in microtubule nucleation from several sites. Whereas the localization of pericentrin is not affected, α- and γ-tubulin localization and sites of nucleation are greatly altered by C19ORF5 depletion. This may indicate that C19ORF5 plays a role in anchoring the microtubule-organizing center to the centrosomes. In addition, we show that the NH&lt;sub&gt;2&lt;/sub&gt; terminus of C19ORF5 is essential for this process. This novel role for C19ORF5 could explain the resulting mitotic abnormalities that occur on its depletion and can potentially provide an underlying mechanism for the frequent centrosome and microtubule abnormalities detected in several cancers. [Cancer Res 2007;67(2):492–500]&lt;/p&gt;&lt;/div&gt;
The Abbott HeartMate 3™ Left Ventricular Assist System (2019)

Mechanical circulatory support devices are increasingly used to treat chronic, advanced heart failure. In the Abbott HeartMate 3™ left ventricular assist system (HM3), a new magnetic levitation pump improves hemocompatibility and thus addresses the prominent morbidities associated with these devices, such as pump thrombosis, stroke, and bleeding. In the multicenter MOMENTUM 3 clinical trial of 366 patients, the primary endpoint—survival without disabling stroke or pump replacement—was 77.9% in the HM3 group (<italic>n</italic> = 190) and 56.4% in the HeartMate II™ Left Ventricular Assist System group (HMII; <italic>n</italic> = 176; <italic>P</italic> &lt;0.001). Suspected or confirmed pump thrombosis occurred in two patients (1.1%) in the HM3 group and in 27 patients (15.7%) in the HMII group (<italic>P</italic> &lt;0.001). Also at 2 years, 22 strokes occurred in 19 patients (10.1%) with the HM3 and 43 strokes occurred in 33 patients (19.2%) with the HMII (<italic>P</italic> = 0.02), indicating that the HM3 provides important improvements in care.
The Relationship Between Preoperative General Mental Health and Postoperative Quality of Life in Minimally Invasive Lumbar Spine Surgery (2015)

In a patient sample with mental health scores comparable to the population mean, there is no relationship between preoperative general mental health and postoperative patient-centered outcomes. Surgeons should consider the dynamic relationships between patient disability, mental health, and pain levels in assessing quality of life at different time points.
Automated detection of neutralizing SARS-CoV-2 antibodies in minutes using a competitive chemiluminescence immunoassay (2022)

The SARS-CoV-2 pandemic has shown the importance of rapid and comprehensive diagnostic tools. While there are numerous rapid antigen tests available, rapid serological assays for the detection of neutralizing antibodies are and will be needed to determine not only the amount of antibodies formed after infection or vaccination but also their neutralizing potential, preventing the cell entry of SARS-CoV-2. Current active-virus neutralization assays require biosafety level 3 facilities, while virus-free surrogate assays are more versatile in applications, but still take typically several hours until results are available. To overcome these disadvantages, we developed a competitive chemiluminescence immunoassay that enables the detection of neutralizing SARS-CoV-2 antibodies within 7 min. The neutralizing antibodies bind to the viral receptor binding domain (RBD) and inhibit the binding to the human angiotensin-converting enzyme 2 (ACE2) receptor. This competitive binding inhibition test was characterized with a set of 80 samples, which could all be classified correctly. The assay results favorably compare to those obtained with a more time-intensive ELISA-based neutralization test and a commercial surrogate neutralization assay. Our test could further be used to detect individuals with a high total IgG antibody titer, but only a low neutralizing titer, as well as for monitoring neutralizing antibodies after vaccinations. This effective performance in SARS-CoV-2 seromonitoring delineates the potential for the test to be adapted to other diseases in the future.
Keyhole Contralateral Interhemispheric Endoscopic-Assisted Resection of an Ependymoma of the Third Ventricle (2017)

Approaches to the third ventricle must ensure integrity of the fornices, thalami, and other critical structures that reside in the surgical corridor to the third ventricle. In this video, we present the case of a 71-year-old man with a history of a myxopapillary ependymoma involving the conus, who presented after resection with evidence of increased intracranial pressure. Imaging revealed a ventricular mass, concerning for metastatic ependymoma. The lesion was approached using a contralateral interhemispheric approach for endoscopic-assisted resection of the lesion. Alternative approaches to this lesion include transcortical and microscopic interhemispheric approaches. The lesion was resected completely, and the patient was neurologically intact after resection, with intact short-term and long-term memory. In addition to the zero-degree endoscope used in this case, angled endoscopes can assist with visualization of the resection cavity to avoid leaving residual tumor. Surgical nuances and technical pearls of the keyhole contralateral interhemispheric approach are illustrated using a 3-dimensional video and anatomical dissections. Consent for the use of clinical material for educational purposes was obtained in all cases. Used with permission from Barrow Neurological Institute. Watch now at https://academic.oup.com/ons/article-lookup/doi/10.1093/ons/opx078 {"href":"Single Video Player","role":"media-player-id","content-type":"play-in-place","position":"float","orientation":"portrait","label":"Keyhole Contralateral Interhemispheric Endoscopic-Assisted Resection of an Ependymoma of the Third Ventricle","caption":"","object-id":[{"pub-id-type":"doi","id":""},{"pub-id-type":"other","content-type":"media-stream-id","id":"1_ut6pz13y"},{"pub-id-type":"other","content-type":"media-source","id":"Kaltura"}]} Disclosure The authors have no personal, financial, or institutional interest in any of the drugs, materials, or devices described in this article.
Theoretical Models for Binder Burnout (1990)

The kinetics of binder burnout, from a ceramic green body, are considered for the case of an “unzipping” binder which decomposes to produce a volatile monomer. The process is considered to fail if the concentration of monomer in the green body exceeds that in equilibrium with vapor at 1 atm (≅10 5 Pa), when an internal bubble would be expected to form. Steady‐state diffusional calculations and computer simulations explore the size and temperature dependence of the process and are in agreement. The model suggests that it is not feasible to burn out a large flat piece greater than about 3 mm thick, without going to very long times of burnout. The kinetics are significantly improved if porosity develops in the piece during the early stages of decomposition, as opposed to the retreat of the binder into the piece on a uniform front.
Time Course of Fluorescence Intensity and Protein Expression in HeLa Cells Stably Transfected with hrGFP (2003)

The green fluorescent protein (GFP), obtained from Aequorea victoria, is widely used in transfection experiments to study the dynamics and characteristics of gene expression in a non-invasive manner. However, generation of cell lines displaying long-term expression of the GFP protein has repeatedly been reported unsuccessful. In the present study a different marker protein, humanized GFP (hrGFP) obtained from a sea pansy, Renilla reniformis, was used for transfection, and the time course of protein expression was studied by live cell fluorescence microscopy, PCR technology, and immunoblotting. HeLa cells were transfected with a plasmid, phrGFP-IRES-Neo containing the neomycin cassette and the hrGFP gene together with an internal ribosome entry site (IRES) sequence under the control of a CMV promotor. Cells were selected for three weeks after transfection using G418. During this time, hrGFP fluorescence was highest around day 4 and decreased thereafter eventually disappearing until the end of the selection period. In parallel, the proportion of cells staining positive for propidium iodide (i.e. dead cells) increased steadily. Three weeks after transfection non-fluorescent clones were present throughout. A couple of clones were subcultured for another week and used for further analyses. PCR methodology revealed the insertion of the hrGFP into the HeLa genome and the presence of mRNA species coding for hrGFP following reverse transcription. However, immunoblot analysis failed to show expression of the protein. These observations suggest a down-regulation of hrGFP expression at both transcriptional and post-transcriptional levels similar to results previously obtained with GFP. Thus, use of hrGFP does not appear to offer an advantage over GFP in transfection experiments aiming at permanent expression of the marker protein.
Dynamic Modeling of Satellite Tether Systems Using Newton’s Laws and Hamilton’s Principle (2007)

Abstract The objective of this paper is to derive the dynamic equations of a tether as it is deployed or retrieved by a winch on a satellite orbiting around Earth using Newton’s laws and Hamilton’s principle and show the equivalence of the two methods. The main feature of this continuous system is the presence of a variable length domain with discontinuities. Discontinuity is present at the boundary of deployment because of the assumption that the stowed part of the cable is unstretched and the deployed part is not. Developing equations for this variable domain system with discontinuities, specially using Hamilton’s principle, is a nontrivial task and we believe that it has not been adequately addressed in the literature.
A 3D Hexaporous Carbon Assembled from Single‐Layer Graphene as High Performance Supercapacitor (2012)

Thumbs up for porous graphene! Single-layer-graphene-assembled 3D hexaporous carbon is prepared by catalyst-free pyrolysis of poly(4-styrenesulfonic acid-co-maleic acid) sodium salt. The material has a hierarchical structure of mesoporous as well as microporous graphene with hexagonal nanopores of uniform size and shape. The results show that the sample is highly conducting in aqueous electrolyte, with an extremely high surface area of 1720 m2 g−1 and an enhanced capacitance of 154 F g−1. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A Study of Conduction Noise Suppression Control for Two-Motor Drive Systems (2021)

This paper introduces a pulse-width modulation (PWM) method for a two-motor drive system that reduces the propagation of conduction noise to the power supply. This two-motor drive system consists of two motors with each of the two inverters connected to a common DC bus. The proposed method suppresses the common mode voltage ideally to zero by shifting the rise and fall times of the output voltage of each inverter. Our experimental results show that the rise and fall times of the output voltage can be synchronized even when the two inverters are driven at different amplitudes and frequencies. We further confirmed that the proposed method suppresses the propagation of conduction noise to the power supply.
Alcohol and Alkane Organic Extraction Using Pervaporation Process (2019)

In this work, different feed mixtures are investigated for the separation of alcohol‐water, toluene‐water, alcohol‐toluene, and alkane‐toluene mixtures by pervaporation using a poly (dimethylsiloxane) membrane (PDMS). The polymeric membrane is characterized by Fourier transform infrared spectrometry (FTIR), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). The total flux and membrane selectivity for hexane‐toluene mixtures are found to be greater than those obtained for heptane‐toluene, alcohol‐toluene, toluene‐water, and alcohol‐water mixtures. Moreover, the total flux and selectivity for the alkane‐toluene mixtures are found to be higher than those obtained for the alcohol‐toluene mixtures. The feed concentration and the temperature for hexane‐toluene mixture have the same effect on the membrane total flux. Overall, the pervaporation separation index (PSI) decreases with increasing feed concentration. The highest PSI value of 20 359 g m −2 h −1 is found at a hexane feed concentration of 10 wt%, a temperature of 40 °C, a permeation flux equal to 717 g m −2 h and a selectivity of 29.
Autoreactive cytotoxic T lymphocytes in human immunodeficiency virus type 1-infected subjects. (1996)

A subtractive analysis of peptides eluted from major histocompatibility complex (MHC) class I human histocompatibility leukocyte antigen (HLA)-A2.1 molecules purified from either human immunodeficiency virus type-1 (HIV-1)-infected or uninfected cells was performed using micro high-performance liquid chromatography and mass spectrometry. Three peptides unique to infected cells were identified and found to derive from a single protein, human vinculin, a structural protein not known to be involved in viral pathogenesis. Molecular and cytofluorometric analyses revealed vinculin mRNA and vinculin protein overexpression in B and T lymphocytes from HIV-1-infected individuals. Vinculin peptide-specific CTL activity was readily elicited from peripheral blood lymphocytes of the majority of HLA-A2.1+, HIV+ patients tested. Our observations suggest that atypical vinculin expression and MHC class I-mediated presentation of vinculin-derived peptides accompany HIV infection of lymphoid cells in vivo, with a resultant induction of antivinculin CTL in a significant portion of HIV+ (HLA-A2.1+) individuals.
Optical Sensors 2011; and Photonic Crystal Fibers V (2011)

We propose a rigorous electromagnetic analysis for a Photonic Crystal Fiber (PCF) geometry consisting of multiple hollow slits that go across the fiber core along the propagation axis z. The slits are regarded as invariant along the transverse dimension x but exhibit multiple sinusoidal bends in the y-z plane, which prevents the transversal profile being constant along the z axis. To analyze and characterize the electromagnetic behavior of the considered PCF geometry, we use a 2D Finite-Difference Time-Domain (FDTD) scheme assuming an ultrashort incident pulse with a polarization angle of 45 degrees as the excitation source. Our analysis focuses on three key aspects for the ultrashort pulse propagation through the slit array: pulse shaping and delay, spatiotemporal dispersion and birefringence features. Numerical FDTD simulations illustrate the effect of the slit array parameters on the previous magnitudes. Our results demonstrate that the proposed structure provides with a wide and deep control over the pulse propagation and wavefront.
On Permeability Prediction From Complex Conductivity Measurements Using Polarization Magnitude and Relaxation Time (2018)

Abstract Geophysical length scales determined from complex conductivity (CC) measurements can be used to estimate permeability when the electrical formation factor F is known. Two geophysical length scales have been proposed: (1) the specific polarizability normalized by the imaginary conductivity and (2) the time constant multiplied by a diffusion coefficient . The parameters and account for the control of fluid chemistry and/or varying minerology on the geophysical length scale. We evaluated the predictive capability of two CC permeability models: (1) an empirical formulation based on or normalized chargeability and (2) a mechanistic formulation based on . The performance of the CC models was evaluated against measured ; and further compared against that of well‐established estimation equations that use geometric length scales. Both CC models predict permeability within one order of magnitude for a database of 58 sandstone samples, with the exception of samples characterized by high pore volume normalized surface area . Variations in and likely contribute to the poor model performance for the high samples, which contain significant dolomite. Two observations favor the implementation of the ‐based model over the ‐based model for field‐scale estimation: (1) a limited range of variation in relative to and (2) field measurements are less time consuming to acquire relative to . The need for a reliable field‐estimate of limits application of either model, in particular the model due to a high power law exponent associated with .