gebhart/patrepeval huggingface dataset:
Enhancement of Physics-of-Failure Prognostic Models with System Level Features (2002)

To truly optimize the deployment of DoD assets, there exists a fundamental need for predictive tools that can reliably estimate the current and reasonably predict the future capacity of complex systems. Prognosis, as in all true predictions, has inherent uncertainty, which has been treated through probabilistic modeling approaches. The novelty in the current prognostic tool development is that predictions are made through the fusion of stochastic physics-of-failure models, relevant system or component level health monitoring data and various inspection results. Regardless of the fidelity of a prognostic model or the quantity and quality of the seeded fault or run-to-failure data, these models should be adaptable based on system health features such as vibration, temperature, and oil analysis. The inherent uncertainties and variability in material capacity and localized environmental conditions, as well as the realization that complex physics-of-failure understanding will always possess some uncertainty, all contribute to the stochastic nature of prognostic modeling. However, accuracy can be improved by creating a prognostic architecture instilled with the ability to account for unexpected damage events, fuse with diagnostic results, and statistically calibrate predictions based on inspection information and real-time system level features. In this paper, the aforementioned process is discussed and implemented first on controlled failures of single spur gear teeth and then on a helical gear contained within a drivetrain system. The stochastic, physics-of-failure models developed are validated with transitional run-to-failure data developed at Penn State ARL. Future work involves applying the advanced prognostics process to helicopter gearboxes.
Selective laser sintering of microwave components (2005)

This paper investigates the fabrication of functional microwave components using the selective laser sintering process to sinter conventional screen printing inks. This technique has the potential to metallize low-temperature substrates by controlling the laser parameters. The quality of the metallization is examined both at DC as well as microwave frequencies. DC resistance of conductors is measured, followed by measurements of the Q of microstrip resonators on both quartz and soda-lime glass.
Multiparametric ultrasound and machine learning for prostate cancer localization (2022)

A cost-effective, widely available, and practical di-agnostic imaging tool for prostate cancer (PCa) localization is still lacking. Recently, the contrast-ultrasound dispersion imaging (CUDI) technique has been developed for PCa localization by quantifying dynamic contrast-enhanced ultrasound (DCE-US) acquisitions. Tissue stiffness is an additional PCa biomarker that can be quantified by ultrasound shear-wave elastography (SWE). In this work, a dedicated preprocessing of 3D DCE-US acquisitions was investigated by using multilinear singular value decomposition (MLSVD), aiming at improving the CUDI performance. Moreover, the diagnostic potential of a multiparametric ultrasound imaging approach combining 3D CUDI features with SWE tissue elasticity for clinically significant (cs)PCa localization was evaluated by comparison with the histopathological outcome of systematic biopsies. In this multiparametric approach, the performance of five classifiers was evaluated and compared for biopsy-region csPCa classification. The classification performance was assessed by the area under the Receiver Operating Characteristics curve (AUC) in a k-fold cross validation fashion comprising sequential floating forward selection of the features. The combination of CUDI features with MLSVD preprocessing and SWE elasticity yielded the best AUC=0.87 for csPCa localization. Our results suggest 3D multiparametric ultrasound imaging approach combing a dedicated preprocessing step to be a useful tool for PCa diagnostics.
The Role of a Confined Space on the Reactivity and Emission Properties of Copper(I) Clusters (2022)

Metal clusters have gained a lot of interest for their remarkable photoluminescence and catalytic properties. However, a major drawback of such materials is their poor stability in air and humidity conditions. Herein we describe a versatile method to synthesize luminescent Cu(I) clusters inside the pores of zeolites, using a sublimation technique with the help of high vacuum and high temperature. The porous materials play an essential role as a protecting media against the undesirable and easy oxidation of Cu(I). The obtained clusters show fascinating luminescence properties, and their reactivity can be triggered by insertion in the pores of organic monodentate ligands such as pyridine or triphenylphosphine. The coordinating ligands can lead to the formation of Cu(I) complexes with completely different emission properties. In the case of pyridine, the final compound was characterized and identified as a cubane-like structure. A thermochromism effect is also observed, featuring, for instance, a hypsochromic effect for a phosphine derivative at 77K. The stability of the encapsulated systems in zeolites is rather enthralling: they are stable and emissive even after several months in the air.
Improved performance of oxide-confined vertical-cavity surface-emitting lasers using a tunnel injection active region (1997)

Data are presented on vertical-cavity surface-emitting lasers that use tunneling for injection of electrons into a quantum well active region. The tunneling injection scheme increases the electronic confinement and improves the lasing performance for small active areas. A lasing threshold of 36 μA with a slope efficiency of 23% is achieved for a 2.5 μm device, and a 52% slope efficiency is achieved for a 4 μm device with a 92 μA threshold.
Adhesives (2000)

Abstract An adhesive is a material capable of holding together solid materials by means of surface attachment. Adhesion is the physical attraction of the surface of one material for the surface of another. There is no unifying theory of adhesion describing the relationship between practical adhesion and the basic intermolecular and interatomic interactions which take place between the adhesive and the adherend. The existing adhesion theories are, for the most part, rationalizations of observed phenomena, although predictions regarding the relative ranking of practical adhesion can actually be made. These theories include diffusion theory , which assumes mutual solubility of the adherend and adhesive, electrostatic theory, surface energetics and wettability theory , and mechanical interlocking theory , in which the adhesive is applied to a surface which is microscopically rough. For good adhesion, the adhesive and the adherend should, if possible, display mutual solubility to the extent that both diffuse into one another. The three principal forces to which adhesive bonds are subjected are a shear force in which one adherend is forced past the other, peeling in which at least one of the adherends is flexible enough to be bent away from the adhesive bond, and cleavage force, which is very similar to the peeling force. A structural adhesive is a resin system, usually a thermoset, that is used to bond high strength materials. Structural adhesives are the strongest form of adhesive and are meant to hold loads permanently. A pressure‐sensitive adhesive, a material which requires no activation other than the finger pressure, exerts a strong holding force, and should be removable from a smooth surface. Hot‐melt adhesives are 100% nonvolatile thermoplastic materials that can be heated to a melt and then applied as a liquid to an adherend; an example is sealing wax. Solvent‐based adhesives are materials that are formed by solution of a high molecular weight polymer in an appropriate solvent. Phenolics, poly(vinyl acetate) adhesives, rubber cements, and hot‐melt adhesives are the leading adhesive products in terms of monetary value. These products are used primarily in the wood, paper, and packaging industries.
Could Intelligent Computers Postulate Their Own Evolution Theory Which Would Be More Plausible than that of the Humans? (2018)

How did life come into existence on Earth? Although many scientific theories and hypotheses have been drawn, we have not yet been able to provide a detailed answer to this fundamental question. What if intelligent computers would someday be in a condition to postulate their own evolution theory which would explain how they came into the world, how would this theory look like? And how would it stand in comparison to the humans’ theory? Let us suppose that a thousand years from now, intelligent and self-aware computers who, for any reason whatsoever, had lost all contacts with humans, and had continued to self-develop and improve by themselves, slowly began to wonder about how they came into the world? These intelligent computers may eventually develop a coherent theory of evolution, which would seemingly explain their existence. How would their theory stand in comparison to our theory of evolution? Would it be less comprehensive or viable? Taking into consideration the inorganic nature of computers, their relative simplicity compared to the human body, and the closeness of their components to the surrounding inorganic environment, it would not be a surprise if their theory would be more plausible than that of the humans. So, what would this signify and mean to our scientific theories in general?
Thermo-Electro-Mechanical Shakedown Response of Conditioned Shape Memory Alloy Wires (2009)

The shakedown response of conditioned shape memory alloy wires (Flexinol®) is examined experimentally during constant tension thermal cycles, at several load levels. Strain, temperature, and electrical resistivity are measured simultaneously using a specialized experimental setup that enables a relatively rapid temperature rate (1 °C/s) while preserving the temperature uniformity along the gauge length to less than 1.5 °C. Both elongation and electrical resistance are measured from the same local gauge length, allowing strain-corrected electrical resistivity to be inferred. The most repeatable behavior (least shakedown) occurs at the intermediate load of 191 MPa (consistent with the supplier’s maximum stress recommendation), with a small amount of shakedown (and some loss of two-way shape memory) at lower loads and progressively larger shakedown (strain ratcheting and reduction in hysteresis) at higher loads.
Lysyl oxidase regulation and protein aldehydes in the injured newborn lung (2021)

During newborn lung injury, excessive activity of lysyl oxidases (LOXs) disrupts extracellular matrix (ECM) formation. Previous studies indicate that TGFβ activation in the O<sub>2</sub>-injured mouse pup lung increases lysyl oxidase (LOX) expression. But how TGFβ regulates this, and whether the LOXs generate excess pulmonary aldehydes are unknown. First, we determined that O<sub>2</sub>-mediated lung injury increases LOX protein expression in TGFβ-stimulated pup lung interstitial fibroblasts. This regulation appeared to be direct; this is because TGFβ treatment also increased LOX protein expression in isolated pup lung fibroblasts. Then using a fibroblast cell line, we determined that TGFβ stimulates <i>LOX</i> expression at a transcriptional level via Smad2/3-dependent signaling. <i>LOX</i> is translated as a pro-protein that requires secretion and extracellular cleavage before assuming amine oxidase activity and, in some cells, reuptake with nuclear localization. We found that pro-LOX is processed in the newborn mouse pup lung. Also, O<sub>2</sub>-mediated injury was determined to increase pro-LOX secretion and nuclear LOX immunoreactivity particularly in areas populated with interstitial fibroblasts and exhibiting malformed ECM. Then, using molecular probes, we detected increased aldehyde levels in vivo in O<sub>2</sub>-injured pup lungs, which mapped to areas of increased pro-LOX secretion in lung sections. Increased activity of LOXs plays a critical role in the aldehyde generation; an inhibitor of LOXs prevented the elevation of aldehydes in the O<sub>2</sub>-injured pup lung. These results reveal new mechanisms of TGFβ and LOX in newborn lung disease and suggest that aldehyde-reactive probes might have utility in sensing the activation of LOXs in vivo during lung injury.
A model transformation tool for performance simulation of complex uml models (2008)

We present a tool that automatically translates UML2 models of service-oriented systems to models for performance evaluation by a commercial simulator. The strength of our tool lies in its support for complex behaviors, which is made possible by a rich intermediate metamodel with clear operational semantics.
Preparation of an ecdysone immunogen for radioimmunoassay work. (1980)

A highly improved procedure for the preparation of ecdysone-protein conjugates for immunological work is reported. Bovine thyroglobulin is succinylated and the succinylated protein is coupled to beta-ecdysone with 1-ethyl-3-(-dimethylaminopropyl)-carbodiimide in the presence of the acylation catalyst 4-dimethylaminopyridine, The antiserum obtained using this immunogen provides a radioimmunoassay sensitive to 25 pmol of beta-ecdysone. The anti-ecdysone antibody cross-reacts with alpha-ecdysone but not with cholesterol or progesterone. This procedure reverses the standard strategy for synthesizing ester linkages in hapten-protein conjugates and should have widespread applicability for the preparation of other such conjugates for immunological work.
The IgD-binding domain of the Moraxella IgD-binding protein MID (MID 962-1200 ) activates human B cells in the presence (2006)

Moraxella catarrhalis immunoglobulin D (IgD)-binding protein (MID) is an outer mem- brane protein with specific affinity for soluble and cell-bound human IgD. Here, we demonstrate that mutated M. catarrhalis strains devoid of MID show a 75% decreased activation of human B cells as compared with wild-type bacteria. In contrast to MID-expressing Moraxella, the MID-deficient Moraxella mutants did not bind to human CD19 IgD B cells. The smallest MID fragment with pre- served IgD-binding capacity comprises 238 amino acids (MID 962-1200 ). To prove the specificity of MID 962-1200 for IgD, a Chinese hamster ovary (CHO) cell line expressing membrane-anchored human IgD was manufactured. MID 962-1200 bound strongly to the recombinant IgD on CHO cells. Moreover, MID 962-1200 stimulated peripheral blood lymphocyte (PBL) proliferation 5- and 15- fold at 0.1 and 1.0 g/ml, respectively. This acti- vation could be blocked completely by antibodies
Image coding from the wavelet transform extrema (2003)

Summary form only given, as follows. A multiresolution edge detection can be performed with a wavelet transform. Indeed, for some particular wavelets, the wavelet transform of an image provides the local gradient of the image at different resolutions. A multiresolution edge detection is therefore equivalent to a detection of local extrema in the image wavelet transform (local extrema of the image gradient). It is shown that one can build a complete image representation by recording the value and the position of these local extrema on a dyadic sequence of resolutions: 1/2, 1/4, 1/8 etc. An iterative procedure that reconstructs the image from these local extrema is described. The algorithm is based on the reproducing kernal of a wavelet transform; it is numerically stable. This reconstruction shows that an image can be coded from the edges which appear on a dyadic sequence of resolutions, without losing any information. Such an adaptive coding is useful for pattern recognition but also for data compression. Indeed, the edges of an image can be efficiently coded into chains with predictive techniques.
LSR Extensions for BIER over Ethernet (2019)

Bit Index Explicit Replication (BIER) [RFC8279] is an architecture
that provides multicast forwarding through a domain without
requiring intermediate routers to maintain multicast related per-flow
state. BIER can be supported in MPLS and non-MPLS networks. The common
BIER header format and encapsulation for MPLS and non-MPLS networks is
specified in [RFC8296]. This document specifies the required
extensions to the IS-IS [RFC1195] and OSPFv2 [RFC2328] protocol for
supporting BIER in non- MPLS networks using BIER in Ethernet
encapsulation.
TBone: An Interactive WaveGuide Brass Instrument Synthesis Workbench for the NeXT Machine (1991)

This initial experience suggests that bridging to transplantation can be successfully approached with a small and quiet axial flow pump that provides low incidence of device infection and pump failure. The incidence of pump thrombus and thromboembolism is being addressed by incorporation of heparin coating to all device surfaces.
Inhibition of Early Stages of HIV-1 Assembly by INI1/hSNF5 Transdominant Negative Mutant S6 (2010)

INI1/hSNF5 is an HIV-1 integrase (IN) binding protein specifically incorporated into virions. A truncated mutant of INI1 (S6, amino acids 183 to 294) harboring the minimal IN binding Rpt1 domain potently inhibits HIV-1 particle production in a transdominant manner. The inhibition requires interaction of S6 with IN within Gag-Pol. While INI1 is a nuclear protein and harbors a masked nuclear export signal (NES), the transdominant negative mutant S6 is cytoplasmic, due to the unmasking of NES. Here, we examined the effects of subcellular localization of S6 on HIV-1 inhibition and further investigated the stages of assembly that are affected. We found that targeting a nuclear localization signal-containing S6 variant [NLS-S6(Rpt1)] to the nucleoplasm (but not to the nucleolus) resulted in complete reversal of inhibition of particle production. Electron microscopy indicated that although no electron-dense particles at any stage of assembly were seen in cells expressing S6, virions were produced in cells expressing the rescue mutant NLS-S6(Rpt1) to wild-type levels. Immunofluorescence analysis revealed that p24 exhibited a diffuse pattern of localization within the cytoplasm in cells expressing S6 in contrast to accumulation along the membrane in controls. Pulse-chase analysis indicated that in S6-expressing cells, although Gag(Pr55(gag)) protein translation was unaffected, processing and release of p24 were defective. Together, these results indicate that expression of S6 in the cytoplasm interferes with trafficking of Gag-Pol/Gag to the membrane and causes a defective processing leading to inhibition of assembly at an early stage prior to particle formation and budding.
Rapid Symptom Resolution with Delayed-Release Mesalamine 4.8g/d Compared to 2.4g/d in Moderately Active Ulcerative Colitis Patients with a History of More Difficult to Treat Disease (2009)

Purpose: To evaluate the time to resolution of the hallmark symptoms of ulcerative colitis (UC) (increased stool frequency [SF], rectal bleeding [RB]) in patients with moderately active UC with a history of more difficult to treat disease (i.e., patients previously treated with UC medical therapies). Methods: Data from 2 Phase III, multi-center, randomized, double-blind, 6-week active-control studies (ASCEND I and II) were combined and analyzed. Median time to resolution of the hallmark symptoms of UC with delayed-release mesalamine 4.8g/d (Asacol® HD 800mg tab) was compared to 2.4g/d (Asacol® 400mg tab) in patients with moderately active UC (Physician's Global Assessment=2) who had been previously treated with oral 5-ASAs, rectal therapies, steroids, or multiple medications. Time to resolution (score=0) of UC symptoms was based on first day of resolution according to daily reports from patients via an interactive voice response system. Resolution of SF was defined as a patient's return to normal number of stools per day and resolution of RB was defined as the absence of visible blood in stool. Results: A total of 423 analyzable patients had moderately active UC. Results of the median time to resolution analysis for the overall moderate population and according to previous UC medical therapies are shown in the Table. Conclusion: In general, the magnitude of the dose benefit (Hazard Ratio) for 4.8g/d vs 2.4g/d was greater in patients previously treated with UC medical therapies. Delayed-release mesalamine at a dose of 4.8g/d decreased the median time to resolution of the hallmark symptoms of UC compared to 2.4g/d in moderate UC patients with a history of more difficult to treat disease. Disclosure: Dr Sandborn - Consultant, Advisory Committee, Grant/Research Support from Procter & Gamble Pharmaceuticals, Inc. David Ramsey - Employee of Procter & Gamble Pharmaceuticals, Inc. Dr Sninsky - Consultant, Promotional Speaker, Research support from Procter & Gamble Pharmaceuticals, Inc.Table
Solution-Processed, Ultrathin Solar Cells from CdCl3–-Capped CdTe Nanocrystals: The Multiple Roles of CdCl3– Ligands (2016)

Solution-processed CdTe solar cells using CdTe nanocrystal (NC) ink may offer an economically viable route for large-scale manufacturing. Here we design a new CdCl3(-)-capped CdTe NC ink by taking advantage of novel surface chemistry. In this ink, CdCl3(-) ligands act as surface ligands, sintering promoters, and dopants. Our solution chemistry allows obtaining very thin continuous layers of high-quality CdTe which is challenging for traditional vapor transport methods. Using benign solvents, in air, and without additional CdCl2 treatment, we obtain a well-sintered CdTe absorber layer from the new ink and demonstrate thin-film solar cells with power conversion efficiency over 10%, a record efficiency for sub-400 nm thick CdTe absorber layer.
[Massive Hemorrhage from the Delayed Diaphragmatic Injury due to the Rib Fracture after the Blunt Chest Trauma:Report of a Case]. (2022)

We report a case of delayed diaphragmatic injury caused by lower rib fractures. A 56-year-old male was referred to our hospital due to the fractures of right lower ribs. Chest X-ray revealed pneumothorax, and the patient was hospitalized for follow-up. On the sixth day after the injury, the patient suddenly complained of chest pain and respiratory distress, and then shock status developed. Chest computed tomography (CT) revealed massive pleural effusion. An emergency operation was performed. The injury of the diaphragm was found. Fracture of the lower rib can cause diaphragmatic injury leading to massive hemorrhage.
The Electrochemical Performance of LSM with A-site Non-Stoichiometry under Cathodic Polarization (2017)

Presented by NETL at 43rd International Conference and Exposition on Advanced Ceramics and Composites, 01/19
An efficient, regiospecific synthesis of 4-demethoxydaunomycinone and daunomycinone. (1987)

4-Methoxy and 4-acetoxyhomophthalic anhydrides were prepared by convenient oxidations of homophthalic acid derivatives followed by hydrolysis and dehydrative cyclization. Strong base-induced cycloaddition of these anhydrides to 2-ehloro-6, 6-ethylenedioxy-5, 6, 7, 8-tetrahydro-1, 4-naphthoquinone gave the tetracyclic adducts, which were efficiently converted into 4-demethoxydaunomycinone and daunomycinone.