gebhart/patrepeval huggingface dataset:
Continuous Human Activity Classification With Unscented Kalman Filter Tracking Using FMCW Radar (2020)

Short-range compact radar systems offer attractive modality for localization and tracking of human targets in indoor and outdoor environments for industrial and consumer applications. Micro-Doppler radar reflections from human targets can be sensed and used for human activity classification, which has applications in human-computer interaction and health assessment among others. Traditionally, the detected human targets' location are tracked and its micro-Doppler spectrogram extracted for further activity classification of the human target. In this letter, we propose a novel integrated human localization and activity classification using unscented Kalman filter and demonstrate our results using a short-range 60-GHz frequency modulated continuous wave radar. The proposed solution is shown to result in an improved classification accuracy with the capability of providing uncertainty with associated classification probabilities and, thus, is a simple mechanism to achieve Bayesian classification.
Control of Interchain Contacts, Solid-State Fluorescence Quantum Yield, and Charge Transport of Cationic Conjugated Polyelectrolytes by Choice of Anion (2006)

Simple procedures are provided for exchanging charge-compensating ions in conjugated polyelectrolytes by progressive dilution of the original species and for determining the degree of ion exchange by using X-ray photoelectron spectroscopy. By using these methods, the bromide ions in poly[(9,9-bis(6'-N,N,N-trimethylammoniumbromide)hexyl)fluorene-co-alt-4,7-(2,1,3-benzothiadiazole)]were exchanged with BF4-, CF3SO3-, PF6-, BPh4-, and B(3,5-(CF3)2C6H3)4- (BArF4-). Absorption, photoluminescence (PL), and PL quantum yields (Phi) were measured in different solvents and in solid films cast from methanol. Examination of the resulting trends, together with the spectral bandshapes in different solvents, suggests that increasing the counteranion (CA) size decreases interchain contacts and aggregation and leads to a substantial increase of Phi in the bulk. Size analysis of polymers containing Br- and BArF4- in water by dynamic light scattering techniques indicates suppression of aggregation by BArF4-. Nanoscale current-voltage measurements of films using conducting atomic force microscopy show that hole mobilities and, more significantly, charge injection barriers are CA dependent. These results show that it is possible to significantly modify the optoelectronic properties of conjugated polyelectrolytes by choosing different counterions. A parent conjugated backbone can thus be fine-tuned for specific applications.
DNA Methylation Profiles of Airway Epithelial Cells and PBMCs from Healthy, Atopic and Asthmatic Children (2012)

We characterized a cell specific DNA methylation signature for AECs compared to PBMCs regardless of asthmatic or atopic status. Our data highlight the importance of understanding DNA methylation in the epithelium when studying the epithelial contribution to asthma.
ChemInform Abstract: Stereospecific Reduction of Menthyloxyphosphine‐Boranes with One‐ Electron Reducing Agents. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
NOVEL MECHANISM OF CYTOMEGALOVIRUS INHIBITION BY LEFLUNOMIDE: EQUIVALENT ACTIVITY AGAINST GANCICLOVIR/FOSCARNET-SENSITIVE AND RESISTANT ISOLATES (1998)

444 Despite substantial progress in anti-viral chemotherapy and prophylaxis, cytomegalovirus (CMV) continues to complicate the clinical course of a substantial portion of allograft recipients. Enhancement of viral activity by post-transplantation pharmacologic immune suppression engages the clinician in a constant struggle to balance graft preservation with control of CMV disease. Leflunomide, an inhibitor of protein tryrosine kinase activity and pyrimidine synthesis, is an experimental immunosuppressive agent with demonstrated effectiveness against acute and chronic rejection in animal models. Since kinase activity may be essential in viral replication, we tested the hypothesis that leflunomide might exert inhibitory activity against CMV. Plaque assays performed following inoculation of human fibroblasts or endothelial cells with each of three different clinical strains of CMV demonstrated dramatic, dose-dependent reduction in infectious virus production in the presence of A77 1726 (A77), the active metabolite of leflunomide, but not in the presence of cyclosporine A or tacrolimus. Addition of exogenous uridine restored intracellular pyrimidine nucleotide triphosphates to normal levels (as determined by HPLC), with little or no effect upon viral inhibition. Immunohistochemical staining and northern blot analysis demonstrated that neither CMV immediate early antigen nor late structural glycoprotein B expression were affected by A77, and, as determined by biochemical assay of protein extracts, CMV DNA polymerase activity was likewise unaffected. Hypothesizing that A77 might interfere with virion assembly, we showed by transmission electron microscopy that nascent virions failed to acquire tegument and external membrane in the presence of this agent. Finally, this unique mechanism of viral inhibition led us to employ plaque reduction assays to test the activity of A77 against a CMV isolate exhibiting cross resistance to ganciclovir, foscarnet, and cidofovir. Indeed this isolate exhibited sensitivity to A77 equivalent to the drug-sensitive strains. These findings, together with our previous studies, implicate leflunomide as an effective immunosuppressive agent with the potential to attenuate a major complication of immunosuppression, CMV disease, while also demonstrating a novel mechanism of anti-viral activity.
Spatial properties of excitonexciton interactions in GaN observed by four‐wave‐mixing spectroscopy (2009)

Abstract Spatial imaging of spectrally‐resolved four‐wave mixing (SR FWM) was performed on a GaN film grown on c ‐sapphire substrate. The image obtained from the exciton resonances at zero time delay clearly showed some highly localized reductions in their intensities whose spatial profiles can be mapped out with a spatial resolution of ∼20 m. The image obtained from the evaluation of the quantum beats indicates these reductions correspond to the phase changes between two exciton transitions, reflecting the spatial properties of exciton‐exciton interactions. The line‐localization suggests a contribution of line‐defect to the anomalous interactions (© 2009 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
3D printing of biomimetic vasculature for tissue regeneration (2019)

A simple strategy tailors perfusable and permeable hierarchical microchannel networks from diverse materials.
Dynamic resource allocation for multi-user query execution (1995)

Over the last few years, database systems have expanded into new application domains that require the ability to model complex objects, process large amounts of data, and support complex ad-hoc queries. These new application areas include CAD/CAM, multi-media, data mining, decision-support, and scientific databases. As a result of this expansion, the query execution component is faced with workloads composed of queries that vary significantly in complexity and size. To achieve good system performance for such workloads, it is necessary that resources such as memory, disk bandwidth, and processor bandwidth be effectively allocated during query execution.
In this thesis, we present a new resource management framework for database query execution that is based on concepts from microeconomics. Specifically, we address the difficult problem of managing resources in a multiple-query environment composed of queries with widely varying resource requirements. The central element of the framework is a resource broker that realizes a profit by selling resources to competing operators using a performance-based currency. The guiding principle for brokering resources is profit maximization. In other words, since the currency is derived from the performance objective, the broker can achieve the best performance by making the scheduling and resource allocation decisions that maximize profit. Moreover, the broker employs dynamic techniques and adapts by changing previous allocation decisions while queries are executing.
To determine the viability of the framework, a prototype broker was designed and implemented to manage memory in a multi-user environment. A new dynamic hash join algorithm was developed to allow the broker to dynamically adjust resource allocations. A simulation study demonstrated the effectiveness of the new algorithm compared to previous adaptable hash join algorithms. After evaluating the prototype memory broker against existing memory allocation techniques, the broker was extended to allocate disk bandwidth in addition to memory, and the hash join algorithm was extended to dynamically adapt to changes in its disk bandwidth allocation. The performance studies demonstrate the viability of the broker framework as well as the effectiveness of the adaptable hash join algorithm and the query admission and resource allocation policies developed for the prototype broker.
Modulation of immune responses toward Helicobacter pylori infection by NLRs (INM6P.339) (2015)

Abstract Helicobacter pylori (HP) colonizes 50% of the world’s population resulting in a decades-long gastric infection. Bacterial interaction with host intracellular environment occurs via injection of bacterial components through a TIVSS or intracellular replication. HP has been recognized for its ability to modulate intracellular NOD-like receptors (NLR). Host responses toward the bacterium can result in asymptomatic, pathogenic or even favorable immunity. Mechanisms underlying the dual role of HP as a commensal versus pathogen are not completely understood. We combined computational modeling, bioinformatics and experimental validation to investigate intracellular host-HP interactions. Global transcriptomic analysis on bone marrow-derived macrophages (BMDM) in a gentamycin protection assay unveiled that intracellular colonization of HP upregulated NOD1, NOD2, NLRP3, NLRC5 and inflammasome components (Caspase-1 and -11) but suppressed regulatory NLRX1 which was inversely correlated to TRAF6, NF-B, proinflammatory cytokines and reactive oxygen species. Loss of NLRX1 facilitates bacterial clearance in BMDM and infected mice. Lastly, we constructed a computational model to shed light on complex immune responses and pathway crosstalk regulated by NLRX1 during infection. In conclusion, NLRX1 is associated with chronic bacterial persistence during H. pyloriinfection and it may represent an immune evasion mechanism employed by the bacterium to facilitate long-term host colonization.
Baculovirus Vectors Elicit Antigen-Specific Immune Responses in Mice (2004)

To characterize the induction of antigen-specific immune response mediated by baculovirus, vectors expressing the E2 glycoprotein of hepatitis C virus or the carcinoembryonic antigen (CEA) under the control of the cytomegalovirus immediate-early promoter-enhancer were constructed. Additionally, a baculovirus vector encoding the E2 glycoprotein (Bac-G-E2) and expressing vesicular stomatitis virus glycoprotein (VSV-G) in the viral envelope was generated by inserting the VSV-G coding sequence downstream of the polyhedrin promoter. Mice were subjected to intramuscular, intranasal, or subcutaneous inoculations with Bac-E2 and the cellular immune response was monitored by ELISPOT and intracellular staining. Additionally, humoral response was monitored by titrating anti-E2 antibodies. Induction of a measurable anti-E2 T-cell response was observed only after intramuscular injection and was predominantly CD8(+) specific. The immunogenic properties of baculovirus as vaccine vector were not restricted to E2 because a CEA-specific CD4(+) T-cell response was observed upon intramuscular injection of Bac-CEA. Interestingly, the Bac-G-E2 vector was shown to be a more efficient immunogen than Bac-E2, in view of the 10-fold difference in the minimal dose required to elicit a measurable T-cell response upon intramuscular injection. Induction of inflammatory cytokines such as gamma interferon, tumor necrosis factor alpha, and interleukin-6 was detected as early as 6 h postinjection of Bac-G-E2. Most importantly, both vectors elicited CD8(+) T cells with effector function capable of lysing target cells loaded with a hepatitis C virus-specific epitope. Additionally, enhanced NK cytolytic activity was detected in immunized mice. Thus, these results further demonstrate that baculovirus may be considered a useful vector for gene therapy.
Towards an SI-Traceable Reference Measurement System for Seven Serum Apolipoproteins Using Bottom-Up Quantitative Proteomics: Conceptual Approach Enabled by Cross-Disciplinary/Cross-Sector Collaboration (2020)

Current dyslipidemia management in patients with atherosclerotic cardiovascular disease (ASCVD) is based on traditional serum lipids. Yet, there is some indication from basic research that serum apolipoproteins A-I, (a), B, C-I, C-II, C-III, and E may give better pathophysiological insight into the root causes of dyslipidemia. To facilitate the future adoption of clinical serum apolipoprotein (apo) profiling for precision medicine, strategies for accurate testing should be developed in advance. Recent discoveries in basic science and translational medicine set the stage for the IFCC Working Group on Apolipoproteins by Mass Spectrometry. Main drivers were the convergence of unmet clinical needs in cardiovascular disease (CVD) patients with enabling technology and metrology. First, the residual cardiovascular risk after accounting for established risk factors demonstrates that the current lipid panel is too limited to capture the full complexity of lipid metabolism in patients. Second, there is a need for accurate test results in highly polymorphic and atherogenic apolipoproteins such as apo(a). Third, sufficient robustness of mass spectrometry technology allows reproducible protein quantification at the molecular level. Fourth, several calibration hierarchies in the revised ISO 17511:2020 guideline facilitate metrological traceability of test results, the highest achievable standard being traceability to SI. This article outlines the conceptual approach aimed at achieving a novel, multiplexed Reference Measurement System (RMS) for seven apolipoproteins based on isotope dilution mass spectrometry and peptide-based calibration. This RMS should enable standardization of existing and emerging apolipoprotein assays to SI, within allowable limits of measurement uncertainty, through a sustainable network of Reference Laboratories.
Leveraging a Live/Virtual/Construtive Testbed for the Evaluation of Moving Target Defenses (Presentation). (2021)

Abstract not provided.
Resource/accuracy tradeoffs in software-defined measurement (2013)

Previous work on network measurements have explored several primitives of increasing complexity for measurement tasks at individual nodes, ranging from counters to hashing to arbitrary code fragments. In an SDN network, these primitives may require significant bandwidth, memory and processing resources, and the resources dedicated to these can affect the accuracy of the eventual measurement. In this paper, we first qualitatively discuss the tradeoff space of resource usage versus accuracy for these different primitives as a function of the spatial and temporal measurement granularity, then quantify these tradeoffs in the context of hierarchical heavy hitter detection.
A 256 Pixel Magnetoresistive Biosensor Microarray in 0.18 µm CMOS (2013)

Magnetic nanotechnologies have shown significant potential in several areas of nanomedicine such as imaging, therapeutics, and early disease detection. Giant magnetoresistive spin-valve (GMR SV) sensors coupled with magnetic nanotags (MNTs) possess great promise as ultra-sensitive biosensors for diagnostics. We report an integrated sensor interface for an array of 256 GMR SV biosensors designed in 0.18 μm CMOS. Arranged like an imager, each of the 16 column level readout channels contains an analog front- end and a compact ΣΔ modulator (0.054 mm<sup>2</sup>) with 84 dB of dynamic range and an input referred noise of 49 nT/√Hz. Performance is demonstrated through detection of an ovarian cancer biomarker, secretory leukocyte peptidase inhibitor (SLPI), spiked at concentrations as low as 10 fM. This system is designed as a replacement for optical protein microarrays while also providing real-time kinetics monitoring.
Search for contact interactions in dilepton events from pp collisions at √s = 7 TeV with the ATLAS detector (2012)

This Letter presents a search for contact interactions in the dielectron and dimuon channels using data&#13;\nfrom proton–proton collisions produced by the LHC at&#13;\n√&#13;\ns = 7 TeV and recorded by the ATLAS detector.&#13;\nThe data sample, collected in 2011, corresponds to an integrated luminosity of 1.08 and 1.21 fb−1 in the&#13;\ne+e− and μ+μ− channels, respectively. No significant deviations from the standard model are observed.&#13;\nUsing a Bayesian approach with a prior flat in 1/Λ2, the following 95% CL lower limits are placed on&#13;\nthe energy scale of qq contact interactions: Λ&#13;\n−&#13;\n&gt; 10.1 TeV (Λ&#13;\n+&#13;\n&gt; 9.4 TeV) in the electron channel&#13;\nand Λ&#13;\n−&#13;\n&gt; 8.0 TeV (Λ&#13;\n+&#13;\n&gt; 7.0 TeV) in the muon channel for constructive (destructive) interference in the&#13;\nleft–left isoscalar contact interaction model. Limits are also provided for a prior flat in 1/Λ4.
A High-content Imaging Workflow to Study Grb2 Signaling Complexes by Expression Cloning (2012)

Signal transduction by growth factor receptors is essential for cells to maintain proliferation and differentiation and requires tight control. Signal transduction is initiated by binding of an external ligand to a transmembrane receptor and activation of downstream signaling cascades. A key regulator of mitogenic signaling is Grb2, a modular protein composed of an internal SH2 (Src Homology 2) domain flanked by two SH3 domains that lacks enzymatic activity. Grb2 is constitutively associated with the GTPase Son-Of-Sevenless (SOS) via its N-terminal SH3 domain. The SH2 domain of Grb2 binds to growth factor receptors at phosphorylated tyrosine residues thus coupling receptor activation to the SOS-Ras-MAP kinase signaling cascade. In addition, other roles for Grb2 as a positive or negative regulator of signaling and receptor endocytosis have been described. The modular composition of Grb2 suggests that it can dock to a variety of receptors and transduce signals along a multitude of different pathways1-3. Described here is a simple microscopy assay that monitors recruitment of Grb2 to the plasma membrane. It is adapted from an assay that measures changes in sub-cellular localization of green-fluorescent protein (GFP)-tagged Grb2 in response to a stimulus4-6. Plasma membrane receptors that bind Grb2 such as activated Epidermal Growth Factor Receptor (EGFR) recruit GFP-Grb2 to the plasma membrane upon cDNA expression and subsequently relocate to endosomal compartments in the cell. In order to identify in vivo protein complexes of Grb2, this technique can be used to perform a genome-wide high-content screen based on changes in Grb2 sub-cellular localization. The preparation of cDNA expression clones, transfection and image acquisition are described in detail below. Compared to other genomic methods used to identify protein interaction partners, such as yeast-two-hybrid, this technique allows the visualization of protein complexes in mammalian cells at the sub-cellular site of interaction by a simple microscopy-based assay. Hence both qualitative features, such as patterns of localization can be assessed, as well as the quantitative strength of the interaction.
Invariant measures for Markov processes arising from iterated function systems with place-dependent probabilities (1988)

On considere un processus de Markov en temps discret sur un espace metrique localement compact obtenu par iteration aleatoire des cartes de Lipschitz w 1 , w 2 , ..., w n
Hepatoprotective action of adenovirus‐transferred HNF‐3γ gene in acute liver injury caused by CCl4 (1999)

Hepatocyte nuclear factor-3gamma (HNF-3gamma) is an important regulator of liver-specific genes and the expression of this factor is reduced in the liver injured by carbon tetrachloride (CCl(4)). Wistar rats were infected with a recombinant adenovirus carrying the cDNA for HNF-3gamma (AxCAHNF3gamma) via the tail vein and were treated with CCl(4) by intraperitoneal injection. Liver damage, such as swelling of the hepatocytes and increases in serum marker enzymes were markedly alleviated by AxCAHNF3gamma infection. Interestingly, hepatocyte growth factor (HGF) was strongly induced in the AxCAHNF3gamma-infected liver. Likewise, HNF-1alpha and HNF-1beta levels were increased, but HNF-3alpha and HNF-3beta levels were depressed in the liver. Our results suggest that the transduced HNF-3gamma gene leads to a hepatoprotective effect via the induction of HGF by the combined actions of liver-enriched transcription factors.
Analysis of Sampled Optical Phase-Lock Loops (2007)

Sampled optical phase-lock loops are analyzed using the Z-transform. It is found that the finite sampling rate will result in an effective delay limiting the available stable gain of the loop. The analysis is applied to three example applications, optical wavelength synthesis from a pulsed reference, linear phase-tracking receivers and coherent optical receivers.
On porting VMTP to the x-kernal (1992)

This report describes our port of Stenford transaction protocol VMTP from the BSD 4.3 UNIX kernal implementation to the x-kernal operating system from University of Arizona. The BSD UNIX kernal dependent functions in the VMTP Implementation are Identified. It is described how we have replaced these functions with corresponding parts from the x-kernal. In particular we describe how BSD UNIX "sockets" are replaced with x-kernal parts and how the BSD UNIX buffer system, "mbufs", is moved into user space. The ported version is the so called minimal implementation of VMTP. It only runs in the simulator of the x-kernal.
Metabolism and Synthesis of Lipids in the Polyunsaturated Fatty Acid-Producing Fungus Mortierella alliacea (2011)

The fungal strain Mortierella alliacea YN-15 is a promising industrial producer of polyunsaturated fatty acids (PUFAs), in particular arachidonic acid. In order to more efficiently produce PUFAs, the metabolism of an externally supplied plant oil, α-linolenic acid (ALA)-rich linseed triacylglycerol (TAG), was examined, and time-dependent changes in the composition of its lipid and fatty acid metabolites were traced. Addition of linseed TAG to growing cultures resulted in a transient increase in extracellular 1,2-diacylglycerol (DAG), and even more so of 1,3-DAG, in the mycelia. This was followed by a decrease in both DAGs and an increase in TAG. Eicosapentaenoic acid (EPA), a desaturated and elongated product of ALA, accumulated to a greater extent in cellular phospholipids than in neutral lipids. Moreover, the addition of ALA in free fatty acid form to the culture led to the generation of EPA. However, EPA production was not observed upon addition of ALA-rich 1,2- or 1,3-DAG, indicating that fatty acids released from exogenous lipids were used for resynthesis of mycelial TAG. These results suggested that TAG might be hydrolyzed by extracellular lipases, whereas its synthesis might be catalyzed by intracellular enzymes. Appropriate regulation of such enzymes might be an effective strategy to enhance PUFA production under plant oil supplementation.