gebhart/patrepeval huggingface dataset:
RNF41 interacts with the VPS52 subunit of the GARP and EARP complexes (2017)

RNF41 (Ring Finger Protein 41) is an E3 ubiquitin ligase involved in the intracellular sorting and function of a diverse set of substrates. Next to BRUCE and Parkin, RNF41 can directly ubiquitinate ErbB3, IL-3, EPO and RARα receptors or downstream signaling molecules such as Myd88, TBK1 and USP8. In this way it can regulate receptor signaling and routing. To further elucidate the molecular mechanism behind the role of RNF41 in intracellular transport we performed an Array MAPPIT (Mammalian Protein-Protein Interaction Trap) screen using an extensive set of proteins derived from the human ORFeome collection. This paper describes the identification of VPS52, a subunit of the GARP (Golgi-Associated Retrograde Protein) and the EARP (Endosome-Associated Recycling Protein) complexes, as a novel interaction partner of RNF41. Through interaction via their coiled coil domains, RNF41 ubiquitinates and relocates VPS52 away from VPS53, a common subunit of the GARP and EARP complexes, towards RNF41 bodies.
Regression of Abdominal Aortic Aneurysms by Simultaneous Inhibition of Nuclear Factor κB and Ets in a Rabbit Model (2007)

Because current therapy to treat abdominal aortic aneurysm (AAA), and particularly to manage small AAA, is limited to elective surgical repair, we explored less invasive molecular therapy by simultaneous inhibition of the transcription factors nuclear factor (NF)kappaB and ets using a decoy strategy. Both NFkappaB and ets were shown to be markedly activated in human AAA. In addition, NFkappaB- and ets-positive cells were increased in the aneurysm wall, and a part of the expression of NFkappaB and ets was detected in migrating macrophages. Thus, we used chimeric decoy oligodeoxynucleotides (ODNs) containing consensus sequences of both NFkappaB and ets binding sites to treat AAA. Inhibitory effects of chimeric decoy ODNs on matrix metalloproteinase-1 and -9 expression were confirmed by ex vivo experiments using a human aorta organ culture. To examine the regressive effect in a rabbit already-formed AAA model, transfection by wrapping a delivery sheet containing chimeric decoy ODNs around the aneurysm was performed 1 week after incubation with elastase. Importantly, treatment with chimeric decoy ODNs significantly decreased the size of AAA. Interestingly, significant preservation of elastic fibers was observed with chimeric decoy ODN treatment, accompanied by a reduction of matrix metalloproteinase-2 and -9 and induction of macrophage apoptosis. Regression of AAA was also associated with an increase in elastin and collagen type I and III synthesis in the aneurysm wall. Minimally invasive molecular therapy targeted to the inhibition of NFkappaB and ets is expected to be useful for AAA through the rebalance of matrix synthesis and degradation.
Interpretation of infrared spectra. An audio-visual programme (van der Maas, J. H.) (1975)

ADVERTISEMENT RETURN TO ISSUEPREVBook and Media Revie...Book and Media ReviewNEXTInterpretation of infrared spectra. An audio-visual programme (van der Maas, J. H.)Victor J. Hruby Cite this: J. Chem. Educ. 1975, 52, 8, A386Publication Date (Print):August 1, 1975Publication History Received3 August 2009Published online1 August 1975Published inissue 1 August 1975https://doi.org/10.1021/ed052pA386.2RIGHTS & PERMISSIONSArticle Views110Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
A presence sensor for smart lighting systems (2016)

Knowing whether a room is occupied or not is crucial for improving electrical energy efficiency. For instance, if a given room is empty there is no need for the lights to be turned on. Usually in small rooms such as elevator halls, a PIR sensor is used together with the lighting, but as it lacks of precision, people often are left in the dark after a few minutes. In the present work a device capable of counting people in a room is implemented and analyzed. It is also compared with other solutions.
Magnetic thickness measurement for various iron steels using magnetic sensor and effect of electromagnetic characteristics (2022)

The diagnosis and prevention of the deterioration of iron-steel infrastructure has become an important social issue in recent years. The thickness measurement technique (extremely low-frequency eddy current testing (ELECT)) using a magnetic sensor for detecting steel corrosion at extreme frequency ranges has been previously reported. Using the calibration curves based on the correlation between the phase of the detected magnetic signal and the plate thickness, the plate thickness reduction caused by corrosion can be estimated from the detected phase signal. Iron-steel materials have large changes in electromagnetic characteristics; therefore, the reference calibration data for each type of iron-steel are required for plate thickness estimation. In this study, the effect of electromagnetic characteristics on the magnetic thickness measurement was investigated to improve the thickness estimation. Four types of iron-steel plates (SS400, SM400A, SM490A, and SMA400AW) with thicknesses ranging from 1 mm to 18 mm were measured by ELECT, and the phase change at multiple frequencies of each plate were analyzed. The shift in the phase and linearity regions of the calibration curves for each type of steel plate was observed. To analyze this shift phenomenon, the electromagnetic characteristics (permeability μ and conductivity σ) of each type of steel were measured. Compared with the permeability μ and conductivity σ of each steel plate in the applied magnetic field strength range, the product (σμ) for various steel plates decreased in the following order: SM400 &amp;gt; SS400 &amp;gt;SMA400AW &amp;gt; SM490A. The product of μ and σ is related to the skin depth, indicating the electromagnetic wave attenuation and eddy current phase shift in the material. Therefore, each shift in the calibration curve of each type of iron steel is explained by the changes in the parameters σ and μ.
Endogenous viral genes influence infection with avian leukosis virus (1995)

The influence of endogenous viral (ev) genes on avian leukosis virus (ALV) infection was studied in ALV-free white leghorn chickens exposed to chicks from ALV shedding dams. The study included four lines, each segregating for one ev gene, one line free of ev genes, and four commercial stocks segregating for a number of ev genes. Genes ev12 and ev21 that produce the complete endogenous virus were associated with significant reductions in antibody response to ALV. In commercial stocks with ev21 in all birds, both antibody response and ALV in oviducts were significantly influenced by the genomic background (stock). In one commercial stock, 37.6% of 133 birds with ev21 and only 5.8% of 120 birds without the gene were test-positive for virus in their oviducts at 180 days of age. No such differences were associated with ev1, ev3 or ev6 that do not produce complete endogenous virus. Thus, virus-producing ev genes were a predisposing factor for shedding ALV.
Merrimac (2003)

Merrimac uses stream architecture and advanced interconnection networks to give an order of magnitude more performance per unit cost than cluster-based scientific computers built from the same technology. Organizing the computation into streams and exploiting the resulting locality using a register hierarchy enables a stream architecture to reduce the memory bandwidth required by representative applications by an order of magnitude or more. Hence a processing node with a fixed bandwidth (expensive) can support an order of magnitude more arithmetic units (inexpensive). This in turn allows a given level of performance to be achieved with fewer nodes (a 1-PFLOPS machine, for example, with just 8,192 nodes) resulting in greater reliability, and simpler system management. We sketch the design of Merrimac, a streaming scientific computer that can be scaled from a $20K 2 TFLOPS workstation to a $20M 2 PFLOPS supercomputer and present the results of some initial application experiments on this architecture.
Signal estimation using wavelet-Markov models (2002)

Current wavelet-based statistical signal and image processing techniques such as shrinkage and filtering treat the wavelet coefficients as though they were statistically independent. This assumption is unrealistic; considering the statistical dependencies between wavelet coefficients can yield substantial performance improvements. We develop a new framework for wavelet-based signal processing that employs hidden Markov models to characterize the dependencies between wavelet coefficients. To illustrate the power of the new framework, we derive a new algorithm for signal estimation in nonGaussian noise.
Radially polarized light generation using segmented spirally varying retarder (2008)

We transform a linearly polarized Gaussian beam into a radially polarized doughnut beam using an eight-segment spirally varying retarder (SVR) at wavelength of 808 nm, and obtain > 96% of polarization purity at far field distribution. The SVR is designed based on the linear birefringence of α-barium borate (α-BBO) crystal and fabricated using a dry etching technique.
TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development (2011)

Mutations that truncate the C-terminal non-catalytic moiety of TTBK2 (tau tubulin kinase 2) cause the inherited, autosomal dominant, SCA11 (spinocerebellar ataxia type 11) movement disorder. In the present study we first assess the substrate specificity of TTBK2 and demonstrate that it has an unusual preference for a phosphotyrosine residue at the +2 position relative to the phosphorylation site. We elaborate a peptide substrate (TTBKtide, RRKDLHDDEEDEAMSIYpA) that can be employed to quantify TTBK2 kinase activity. Through modelling and mutagenesis we identify a putative phosphate-priming groove within the TTBK2 kinase domain. We demonstrate that SCA11 truncating mutations promote TTBK2 protein expression, suppress kinase activity and lead to enhanced nuclear localization. We generate an SCA11-mutation-carrying knockin mouse and show that this leads to inhibition of endogenous TTBK2 protein kinase activity. Finally, we find that, in homozygosity, the SCA11 mutation causes embryonic lethality at embryonic day 10. These findings provide the first insights into some of the intrinsic properties of TTBK2 and reveal how SCA11-causing mutations affect protein expression, catalytic activity, localization and development. We hope that these findings will be helpful for future investigation of the regulation and function of TTBK2 and its role in SCA11.
Gain characterization of electrically-pumped VECSELs (2012)

We present the first detailed gain characterization of electrically-pumped VECSELs. Spectral dependence of the gain and the gain saturation behavior of three samples with different field enhancement in the quantum-well layers are investigated.
Selective oxidation of CO in the presence of H2, H2O and CO2utilising Au/α-Fe2O3catalysts for use in fuel cells (2005)

Au/Fe2O3 catalysts prepared using co-precipitation are described and discussed for the preferential oxidation of CO in the presence of H2, H2O and CO2. A catalyst prepared using a two-stage calcination procedure (400 °C followed by 550 °C) achieves target conversion and selectivity (>99.5% CO conversion and >50% selectivity, based on O2, for the competing conversion of H2 with O2 at 80–100 °C) for the competitive oxidation of dilute CO in the presence of moist excess H2 and CO2. The effect of the preparation method of the uncalcined precursor is described and the effects of calcination on the catalyst activity in the absence of H2, CO2 and H2O is initially explored. The catalysts are characterised in detail using electron microscopy (TEM), X-ray photoelectron spectroscopy and Mössbauer spectroscopy. For the target conversion to be achieved, it is necessary that the activity for the reverse water gas shift activity (CO2 + H2 → CO + H2O) of the catalyst is suppressed, since under the fuel cell conditions this reaction reforms CO at high CO conversions due to the presence of excess CO2 and H2. It is proposed that the two stage calcination procedure removes active sites for the water gas shift reaction whilst retaining active sites for preferential CO oxidation.
Supplementary Figures 1-6 from The Phosphoinositide 3-Kinase Regulatory Subunit p85α Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling (2023)

Supplementary Figures 1-6 from The Phosphoinositide 3-Kinase Regulatory Subunit p85α Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling
Differential Thermal Analysis Studies of Vanadium Catalysts for Sulfur Dioxide Oxidation (1972)

反応ガス(7%SO2+空気)流通系のDTA装置によりV205触媒の作動状態における熱的挙動を測定した。用いた触媒はVaO5,Li2SO4-VN205(Li),Na2SO4-V窯05(Na),K2SO4-V2O5(K),KOH-V205(K1),KHSO4-V205(K2),Cs2,SO4-V205(Cs)でMe/V=2.7を標準とした。新しい触媒のDTA曲線にはMe2SOSO3-V205.,系の生成(活性化過程)に対応する400℃付近の発熱ピークと,So3+1/202→So3の反応熱に対応する500℃付近のピークが現われる。活性化した触媒を同-の雰囲気でくり返して得たDTA曲線では400℃付近のピークは消滅した。再現性よく現われる500℃付近のピーク温度から触媒活性は(Cs)487℃,(K)509℃,(K1)509℃,(K2)548℃,(Na)546℃,(Li)603℃であった。DTA曲線から推定した触媒活性物質の融点は(Cs):305℃,(K):407℃,(K1):420℃,(K2):370℃,(Na):410℃,(Li):508℃であり,500℃付近の発熱曲線の開始温度と-致している。これから,活性化過程で生成したMe2SO4-SO3-V205耀系が雇虫解しはじめると同時にSO2の酸化反応に対する触媒活性が顕著になることがわかる。さらにKOH-V205系触媒の活性の経時変化をDTAにより測定した。
Boards and wards : a review for USMLE steps 2 & 3 (2003)

TABLE OF CONTENTS Contributors Reviewers List of Tables List of Algorithms Abbreviations Key Preface Internal Medicine Surgery Obstetrics and Gynecology Pediatrics Family Medicine Psychiatry Neurology Dermatology Ophthalmology Radiology APPENDICES A. Zebras and Syndromes B. Toxicology C. Vitamins and Nutrition Questions Answers Index
Combined impact of double-Rayleigh backscatter and amplified spontaneous emission on receiver noise (2002)

We have expressed the dependence of ASE and DRB beat noises on the optical pulsewidths, optical and electrical filter bandwidths. Using short pulses increases immunity to DRB beat noise, while the use of narrower optical and/or electrical filters emphasizes the impact of DRB beat noise.
Novel Combination of Impella and Extra Corporeal Membrane Oxygenation as a Bridge to Full Recovery in Fulminant Myocarditis (2012)

A 31-year-old male was transferred to our hospital with severe heart failure due to viral myocarditis. He progressed to multiorgan failure requiring intubation and maximal doses of multiple vasopressors. Circulatory support was provided with an Impella device as a bridge to an extracorporeal membrane oxygenation (ECMO) system. On full mechanical cardiovascular support, the patient's hemodynamic status improved and ECMO and Impella were explanted after 48 hours. Three days later, he was extubated and continued on to a full recovery. There are no specific therapies for fulminant myocarditis but first-line treatment is supportive care. ECMO is commonly used in patients with severe heart failure. In severe systolic dysfunction, left ventricular decompression is required to reduce myocardial wall stress, decrease myocardial oxygen requirements, and enhance the chances of recovery. The Impella, an active support system, is less invasive than classical decompressive techniques and is associated with lower requirements for blood products with fewer thromboembolic complications. This is the only case reported of the contemporary use of Impella and ECMO as a bridge to full recovery in an adult with myocarditis. It also presents a novel use of the Impella device in decompressing the left ventricle of an adult patient on ECMO.
Thermodynamically uphill reduction of a surface-confined N,N'-dialkyl-4,4'-bipyridinium derivative on illuminated p-type silicon surfaces (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermodynamically uphill reduction of a surface-confined N,N'-dialkyl-4,4'-bipyridinium derivative on illuminated p-type silicon surfacesDana C. Bookbinder and Mark S. WrightonCite this: J. Am. Chem. Soc. 1980, 102, 15, 5123–5125Publication Date (Print):July 1, 1980Publication History Published online1 May 2002Published inissue 1 July 1980https://pubs.acs.org/doi/10.1021/ja00535a064https://doi.org/10.1021/ja00535a064research-articleACS PublicationsRequest reuse permissionsArticle Views255Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
PR-Set7 is Degraded in a Conditional Cul4A Transgenic Mouse Model of Lung Cancer. (2015)

PR-Set7 is a direct target of Cul4A for degradation and involved in the formation of lung tumors in the conditional Cul4A transgenic mouse model.
Basics and prospective of magnetic Heusler compounds (2015)

Heusler compounds are a remarkable class of materials with more than 1000 members and a wide range of extraordinary multi-functionalities including halfmetallic high-temperature ferri- and ferromagnets, multi-ferroics, shape memory alloys, and tunable topological insulators with a high potential for spintronics, energy technologies, and magneto-caloric applications. The tunability of this class of materials is exceptional and nearly every functionality can be designed. Co2-Heusler compounds show high spin polarization in tunnel junction devices and spin-resolved photoemission. Manganese-rich Heusler compounds attract much interest in the context of spin transfer torque, spin Hall effect, and rare earth free hard magnets. Most Mn2-Heusler compounds crystallize in the inverse structure and are characterized by antiparallel coupling of magnetic moments on Mn atoms; the ferrimagnetic order and the lack of inversion symmetry lead to the emergence of new properties that are absent in ferromagnetic centrosymmetric Heusler structures, such as non-collinear magnetism, topological Hall effect, and skyrmions. Tetragonal Heusler compounds with large magneto crystalline anisotropy can be easily designed by positioning the Fermi energy at the van Hove singularity in one of the spin channels. Here, we give a comprehensive overview and a prospective on the magnetic properties of Heusler materials.
Cardinal Manifestations of Cancer (2022)

Overview Cancer is a singular word that embraces a vast diversity of diseases that can occur in any organ system throughout the animal kingdom. The unique characteristic of cancer is the proliferation of cells of a type different from, if ever so slightly, the normal complement of the organism. The proliferation may be rapid or slow, the accumulation of cells may be massive or miniscule. The essence of the matter, however, is that aberrant cells, distinct from the ordinary evolution of cell types, appear, and accumulate. Thus, a cancer differs from hypertrophy and hyperplasia, which involve normal cells.
Die Opioid-Epidemie in den USA (2018)

Gesundheits- und Sozialpolitik (G&S) , Seite 32 - 39
Bulk Ionic Conductivity and Crystallization of Lithium Thiophosphate Solid Electrolytes (2013)

Abstract not Available.
Partner Quality of Life in the Antiarrhythmics Versus Implantable Defibrillators Trial (2007)

The mean age of the partners was 62 years. Most were white and female. Their mean Short Form-36 scores were comparable to a normative age group. Partner and participant mean Short Form-36 and Quality of Life Index scores correlated modestly (range 0.25-0.36). The physical summary scores of partners using the Short Form-36 declined over time, whereas their mental summary scores remained stable. Partner concerns related to death, dysrhythmia recurrence, and the impact of dysrhythmias on enjoyment of life lessened from baseline to 12 months. Concern about implantable cardioverter defibrillator function remained stable over time. Although the sample size of this study was relatively small and limited by missing data for some assessments, it is the largest prospective study of QOL in partners of patients with serious dysrhythmias. The results offer a foundation for future research of the partners of patients with serious dysrhythmias in terms of identifying their needs, offering support, and maximizing QOL.
Authorship attribution of web forum posts (2010)

Extracting useful information from user generated text on the web is an important ongoing research in natural language processing, machine learning, and data mining. Online tools like emails, news groups, blogs, and web forums provide an effective communication platform for millions of users around the globe and also provide an added advantage of anonymity. Millions of people post information on different web forums daily. The possibility of exchanging sensitive information between anonymous users on these web forums cannot be ruled out. This document proposes a two stage approach for combining unsupervised and supervised learning approaches for performing authorship attribution on web forum posts. During the first stage, the approach focuses on using clustering techniques to make an effort to group the data sets into stylistically similar clusters. The second stage involves using the resulting clusters from stage one as features to train different machine learning classifiers. This two stage approach is an effort towards reducing the complexity of the classification task and boosting the prediction accuracy.
External validation of a deep learning electrocardiogram algorithm to detect ventricular dysfunction (2021)

The AI-ECG detected LVSD with robust test performance in a population that was very different from that used to develop the algorithm. Population-specific cut-offs may be necessary for clinical implementation. Differences in population characteristics, ECG and echocardiographic data quality may affect test performance.