gebhart/patrepeval huggingface dataset:
Evaluation of a supercritical fluid chromatograph coupled to a surface-wave-sustained microwave-induced-plasma detector (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEvaluation of a supercritical fluid chromatograph coupled to a surface-wave-sustained microwave-induced-plasma detectorDebra R. Luffer, Leonard J. Galante, Paul A. David, Milos. Novotny, and Gary M. HieftjeCite this: Anal. Chem. 1988, 60, 14, 1365–1369Publication Date (Print):July 15, 1988Publication History Published online1 May 2002Published inissue 15 July 1988https://pubs.acs.org/doi/10.1021/ac00165a003https://doi.org/10.1021/ac00165a003research-articleACS PublicationsRequest reuse permissionsArticle Views56Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Transport phenomena during freezing of isolated hepatocytes (1992)

Abstract The cellular response of isolated rat hepatocytes to freezing stress under various chemical and physical conditions was investigated using cryomicroscopic observations and a theoretical transport model. Cryomicroscopy was used to determine the cellular dehydration during freezing at different cooling rates. Using these results, water permeability parameters were also obtained. In addition, intracellular ice formation (IIF) parameters were obtained from rapid freezing experiments at a cooling rate of 400°C/min to decouple the effects of dehydration from IIF. The water permeability and IIF parameters were then used in a transport model to predict the probability of IIF under a wide range of chemical and physical conditions observed during cell freezing. In order to verify the model predictions, experiments were performed under similar conditions and compared to the theoretical predictions. The results suggest that slowly cooled cells (&lt; 80°C/min) dehydrate excessively and escape IIF. On the other hand rapidly cooled cells (&gt; 120°C/min) contain enough undercooled cellular water which undergoes IIF between −5 and −12°C.
Atomic and electronic structure of amorphous Al–Zr alloy films (2011)

Amorphous Al(73)Zr(27) alloy film, grown and then subjected to heat treatments at 400 and 700 °C, was studied using a combination of x-ray diffraction and soft x-ray spectroscopic techniques. The Al L(2,3) and Al K x-ray absorption spectroscopy (XAS) and Al L(2,3) x-ray emission spectroscopy (XES) used allowed probing the unoccupied and occupied Al 3s, d states and unoccupied Al 3p states in the sample studied. An irreversible transition from amorphous alloy to a mixture of polycrystalline alloy and amorphous alloy, and then to an amorphous oxide phase was observed. After the annealing at 400 °C the Al L(2,3) spectra obtained by XAS could be explained as sums of spectra from amorphous Al(73)Zr(27) alloy and (poly)crystalline Al. This indicates that the sample consists of a mixture of Al-rich crystalline and Zr-enhanced amorphous alloys, as compared to the stoichiometry of the as-deposited Al(73)Zr(27) sample, and that the electronic wavefunctions in the crystalline and amorphous regions can be considered to be confined within the respective regions. The relative amounts of Al atoms were found to be around 1:3 in the crystalline and amorphous phases, respectively, as deduced from the analysis of changes in the electronic structure using Al L(2,3) XAS data. The interpretation was confirmed by the Al K XAS and Al L(2,3) XES. Upon further annealing at 700 °C the polycrystalline phase transformed into amorphous oxide, while the amorphous alloy phase underwent gradual oxidation. The important finding was that the greater part of the sample remained in the amorphous state throughout the temperature regimes described.
Evaluation of Model for End Stage Liver Disease (MELD)‐based systems as prognostic index for hepatocellular carcinoma (2008)

MELD-based systems performed better than Child-Pugh based systems as prognostic indexes for HCC.
Apelin Treatment Increases Complete Fatty Acid Oxidation, Mitochondrial Oxidative Capacity, and Biogenesis in Muscle of Insulin-Resistant Mice (2011)

Both acute and chronic apelin treatment have been shown to improve insulin sensitivity in mice. However, the effects of apelin on fatty acid oxidation (FAO) during obesity-related insulin resistance have not yet been addressed. Thus, the aim of the current study was to determine the impact of chronic treatment on lipid use, especially in skeletal muscles. High-fat diet (HFD)-induced obese and insulin-resistant mice treated by an apelin injection (0.1 μmol/kg/day i.p.) during 4 weeks had decreased fat mass, glycemia, and plasma levels of triglycerides and were protected from hyperinsulinemia compared with HFD PBS-treated mice. Indirect calorimetry experiments showed that apelin-treated mice had a better use of lipids. The complete FAO, the oxidative capacity, and mitochondrial biogenesis were increased in soleus of apelin-treated mice. The action of apelin was AMP-activated protein kinase (AMPK) dependent since all the effects studied were abrogated in HFD apelin-treated mice with muscle-specific inactive AMPK. Finally, the apelin-stimulated improvement of oxidative capacity led to decreased levels of acylcarnitines and enhanced insulin-stimulated glucose uptake in soleus. Thus, by promoting complete lipid use in muscle of insulin-resistant mice through mitochondrial biogenesis and tighter matching between FAO and the tricarboxylic acid cycle, apelin treatment could contribute to insulin sensitivity improvement.
Patrones de movilidad y variación en las dinámicas de conmutación en la región de los Lagos, sur de Chile (2020)

The Los Lagos Region, in southern Chile, has a continental and an archipelagic-insular part, determining switching processes. This article analyzes, from the theory of graphs, the mobility between the communes of such space at two time points, years 2002 and 2012. The results show the importance of location and distance generating patterns of concentrated mobility and with different centralities. It is noted that within the regional space there is a concentration of commutations in the major cities of Puerto Montt and Osorno, polarizing their own spaces. However, smaller and island cities such as Castro, project themselves as dominant poles in their nearby territory, implying new challenges for the communal capitals.
Nucleus tractus solitarius as mediator of evoked parabrachial cardiovascular responses in the decerebrate rabbit. (1990)

1. The present study has assessed the importance of neurones within the nucleus tractus solitarius (NTS) in mediating the cardiovascular response evoked from the parabrachial nucleus (PBN) in the decerebrate rabbit. Microinjection techniques were employed so that the magnitude of the circulatory responses elicited from the PBN could be compared before, and after, kainic acid or bicuculline were microinjected into restricted regions of the NTS. 2. Electrical stimulation of the PBN (both medial and lateral regions) evoked variable changes in heart rate, a pressor response, vasoconstriction in the hindlimb and an increase in renal sympathetic nerve activity. Glutamate injected into these regions of the PBN elicited a similar pattern of response except that a tachycardia was observed consistently. 3. Both electrical and chemical stimulation of restricted regions of the NTS evoked bradycardia and a depressor response together with an increase in femoral vascular conductance and an inhibition of activity in the renal nerve. 4. Chemical lesions placed in these regions of the NTS by microinjecting kainic acid were found to attenuate both the heart rate and arterial blood pressure responses elicited from sites in the medial and lateral PBN using either electrical or chemical stimulation. Equivalent effects were produced on microinjecting the GABAa receptor antagonist bicuculline into the NTS. 5. These data indicate that NTS neurones play a part in mediating the cardiovascular responses that are evoked from the PBN and suggest that the action of the PBN at the level of the NTS is mediated via a GABAergic mechanism.
Inter- and intra-molecular complex structures of Cu-containing nitrite reductase with cytochromec (2008)

inside surface is located at the D-pathway entrance. The zinc binding affinity for the second site suggests that the zinc site is tightly coupled with the proton-pumping site. Recently, we analyzed Zn/Cd-binding to monomeric CcO which gives crystal packing different from that in the dimeric CcO crystal. The x-ray structural analysis showed Znbinding to the Zn2, Zn3 and additional sites including the site near the K-pathway entrance. Several Zn-binding sites have been found on the outside surface. However none of them is located on the subunit I surface from which pumping protons exit.
Development and validity evidence of an objective structured assessment of technical skills score for minimally invasive linear-stapled, hand-sewn intestinal anastomoses: the A-OSATS score (2021)

With the weighted and unweighted A-OSATS score, we propose a new reliable standard to assess the creation of minimally invasive linear-stapled, hand-sewn anastomoses based on an international expert consensus. Validity evidence in live animal models is provided in this study. Future research should focus on assessing whether the weighted A-OSATS exceeds the predictive capabilities of patient outcomes of the unweighted A-OSATS and provide further validity evidence on using the score on different anastomotic techniques in humans.
Controlled radical polymerization of anthracene-containing methacrylate copolymers for stimuli-responsive materials (2016)

Novel reversible networks utilizing photodimerization of crosslinkable anthracene groups and thermal dissociation were investigated. Reversible addition-fragmentation chain transfer polymerization yielded well-defined copolymers with 9-anthrylmethyl methacrylate (AMMA) and other alkyl methacrylates such as methyl methacrylate (MMA) and 2-ethylhexyl methacrylate (EHMA) having different AMMA compositions. Well-controlled block copolymerization of AMMA and alkyl methacrylates was also successfully accomplished using a trithiocarbonate-terminated poly(alkyl methacrylate) macro-chain transfer agent. The anthracene-containing copolymers showed reversibility via crosslinking based on photodimerization with ultraviolet irradiation and subsequent thermal dissociation. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 2302–2311
Supplementary Methods and Legends from The Mechanism of DAB2IP in Chemoresistance of Prostate Cancer Cells (2023)

&lt;p&gt;Supplementary Methods and Legends - PDF file 114K, All the supplementary legends and methods&lt;/p&gt;
Line Edge Roughness due to Oxide Rie Process : Topic: AM (2019)

The performance of a subset of the logic devices on a recent new design showed unexpected variation. Analysis showed that the nitride/oxide spacer exhibited excessive roughness in certain areas of a logic chip, causing the observed device shift. To execute the experiments required to correct the issue we developed a method to use inline measurement to quantify spacer quality. This helped to improve spacer quality without delaying availability of the product.
Penser les transformations par la comparaison. Action publique, villes et instruments (2018)

1ères lignes : Vous qualifieriez-vous d’abord de sociologue ou de politiste ? Pouvez-vous nous ex-pliquer votre parcours personnel ainsi que les influences qui vous ont amené à finalement travailler sur les questions de gouvernance et d’inégalités urbaines ?\nLes deux. Je suis un chercheur en sciences sociales comparatistes qui travaille sur la sociologie des villes, de la mobilité et des sociétés européennes, sur la gouvernance des grandes villes mondiales, sur la sociologie politique des politiques publiques et de l’État, ainsi que sur la political economy. Je suis sociologue et politiste, mais je travaille en permanence avec des historiens, des géographes, des urbanistes, des économistes et des anthropologues de différents continents.\nJe suis Breton, originaire d’une petite ville industrielle en déclin au bord de la mer, Saint- Brieuc. Après le lycée, comme beaucoup de bons élèves français, je passe le concours d’une grande école à Paris et je rentre à Sciences Po. Mon idée, à l’époque, c’était de faire du développement économique et du développement du territoire en Bretagne. Quand je suis sorti de Sciences Po, j’hésitais entre plusieurs formations. Finalement, alors que je pensais plutôt faire un DESS d’urbanisme, Henri Mendras, qui était mon professeur, m’amène à suivre un diplôme d’études approfondies (master recherche) en sociologie à Nanterre. Je travaillais à l’époque chez Futuribles, l’organisation de prospective, et je me suis dit que ce n’était pas une mauvaise idée d’essayer de passer un an à apprendre des méthodes un peu plus sophistiquées. Mendras avait dans son équipe une excellente chercheuse qui s’appelait Odile Benoît-Guilbot et qui dirigeait la revue Sociologie du travail. Elle m’a dit : « voilà j’ai un contrat de recherche pour travailler sur Elbeuf, c’est une petite ville industrielle en crise près de Rouen, je vous engage dans mon équipe et vous faites votre DEA (Diplôme d’études approfondies) ». C’était une grande chance de pouvoir travailler dans une vraie équipe de recherche pour un an, pour voir à quoi cela ressemble. Je ne pensais absolument pas faire une thèse.\n
Modeling and verification of capacitive quenching in a single photon avalanche diode (2021)

We present modeling and analysis of carrier dynamics in a single-photon avalanche diode (SPAD) operated with a capacitive quenching (CQ) method. The CQ method is regarded as a conventional resistive quenching (RQ) with its quenching resistance infinite or an open circuit. The SPAD is modelled as a lumped circuit consisting of a voltage dependent charge generator representing an avalanching depletion region and a capacitance of the depletion region and parasitic components. The carrier dynamics inside the device is described by time-dependent bipolar continuity equations (BCE) derived from the carrier continuity equations. We solve the BCE numerically with a 0.1 ps time resolution and investigate numbers of carriers in each circuit element as functions of time and of excess bias voltage (|𝑉<sub>ex</sub>|). We find two important characteristics of the CQ method; (1) a single-photon triggered Geiger-mode pulse is guaranteed to be quenched in a stable state (2) a voltage drop of the internal bias of SPAD due to the charges stored on the capacitance is proportional to |𝑉<sub>ex</sub>| with the proportionality factor of two. The results, in turn, enables one to design a SPAD free from after-pulse and from overflow. Such a SPAD pixel is shown to be compatible with a conventional complementary metal-oxide semiconductor (CMOS) image sensor (CIS) with a four transistors configuration pixel circuit. Finally, effectiveness of the present methodology is demonstrated by the subrange synthesis (SRS) time-of-flight (ToF) ranging experiments using a 6 &mu;m size 400 &times; 400 pixels SPAD-based CIS.
<title>Initial clinical performance of a large-field KCD digital radiography system</title> (1996)

The initial clinical performance of a research prototype digital radiographic system based on a large-field (2016-channel) kinestatic charge detector and data acquisition system is discussed. The first clinical images from the large-field system are compared with images of the same patients taken with commercial systems. Future directions are discussed.
Polarization-based vision through haze (2008)

We present an approach for easily removing the effects of haze from passively acquired images. Our approach is based on the fact that usually the natural illuminating light scattered by atmospheric particles (airlight) is partially polarized. Optical filtering alone cannot remove the haze effects, except in restricted situations. Our method, however, stems from physics-based analysis that works under a wide range of atmospheric and viewing conditions, even if the polarization is low. The approach does not rely on specific scattering models such as Rayleigh scattering and does not rely on the knowledge of illumination directions. It can be used with as few as two images taken through a polarizer at different orientations. As a byproduct, the method yields a range map of the scene, which enables scene rendering as if imaged from different viewpoints. It also yields information about the atmospheric particles. We present experimental results of complete dehazing of outdoor scenes, in far-from-ideal conditions for polarization filtering. We obtain a great improvement of scene contrast and correction of color.
Dynamic Modeling of the Organic Rankine Cycle for the Waste Heat Recovery of Internal Combustion Engines (2012)

Using state-of-the-art engine technologies, current gasoline internal combustion engines of passenger vehicles convert only 25∼35% of fuel energy into useful power, and 65∼75% of fuel energy are wasted as heat through engine cooling and exhaust gas systems. One of the promising technologies that can dramatically improve fuel economy is the waste heat recovery system using Organic Rankine Cycle (ORC). The working fluid of the ORC, however, undergoes both liquid and gas phases throughout the cycle, and it is a challenge to develop heat exchanger models that can be used in a simple and efficient dynamic ORC model. In this study, a simplified ordinary differential equation (ODE) ORC model is developed for system-level design and control studies. First, the first principles model of heat exchange dynamics is described by two partial differential equations (PDE) and one ODE, and then the moving-boundary approach is used to lump the distributed parameters of the heat exchanger by integrating three governing equations over each length of three phases (gas, two-phase, and liquid). The simulation results demonstrate that the proposed dynamic ORC model provides key transient dynamics of the ORC with much less computational load.Copyright © 2012 by General Motors
Ranking Power of the SQM/COSMO Scoring Function on Carbonic Anhydrase II–Inhibitor Complexes (2018)

Abstract Accurate prediction of protein–ligand binding affinities is essential for hit‐to‐lead optimization and virtual screening. The reliability of scoring functions can be improved by including quantum effects. Here, we demonstrate the ranking power of the semiempirical quantum mechanics (SQM)/implicit solvent (COSMO) scoring function by using a challenging set of 10 inhibitors binding to carbonic anhydrase II through Zn 2+ in the active site. This new dataset consists of the high‐resolution (1.1–1.4 Å) crystal structures and experimentally determined inhibitory constant ( K i ) values. It allows for evaluation of the common approximations, such as representing the solvent implicitly or by using a single target conformation combined with a set of ligand docking poses. SQM/COSMO attained a good correlation of R 2 of 0.56–0.77 with the experimental inhibitory activities, benefiting from careful handling of both noncovalent interactions (e.g. charge transfer) and solvation. This proof‐of‐concept study of SQM/COSMO ranking for metalloprotein–ligand systems demonstrates its potential for hit‐to‐lead applications.
Characterization of Family D DNA polymerase from Thermococcus sp. 9°N (2014)

Accurate DNA replication is essential for maintenance of every genome. All archaeal genomes except Crenarchaea, encode for a member of Family B (polB) and Family D (polD) DNA polymerases. Gene deletion studies in Thermococcus kodakaraensis and Methanococcus maripaludis show that polD is the only essential DNA polymerase in these organisms. Thus, polD may be the primary replicative DNA polymerase for both leading and lagging strand synthesis. To understand this unique archaeal enzyme, we report the biochemical characterization of a heterodimeric polD from Thermococcus. PolD contains both DNA polymerase and proofreading 3'-5' exonuclease activities to ensure efficient and accurate genome duplication. The polD incorporation fidelity was determined for the first time. Despite containing 3'-5' exonuclease proofreading activity, polD has a relatively high error rate (95 × 10(-5)) compared to polB (19 × 10(-5)) and at least 10-fold higher than the polB DNA polymerases from yeast (polε and polδ) or Escherichia coli DNA polIII holoenzyme. The implications of polD fidelity and biochemical properties in leading and lagging strand synthesis are discussed.
Maternal autonomic responsiveness is attenuated in healthy pregnancy: a phase rectified signal averaging analysis (2022)

Autonomic regulation is essential in enabling a healthy pregnancy. In fact, several pregnancy complications are associated with autonomic dysfunction. Better understanding of the maternal autonomic state during healthy pregnancy may aid in the early detection of such complications. One aspect of autonomic regulation is autonomic responsiveness, which can by assessed by phase rectified signal averaging (PRSA). While other areas of research have found blunted physiological responses in pregnancy, this paper presents the first investigation of maternal autonomic responsiveness as assessed by PRSA. We find significantly reduced rates of responses, as well as an attenuated capacity for heart rate acceleration when comparing pregnant women to non-pregnant controls. We hypothesize that this attenuated autonomic control may serve to protect the mother against her imbalanced autonomic state, as increased sympathetic and decreased parasympathetic modulation accompany healthy pregnancies. Clinical Relevance- Maternal autonomic responsiveness is attenuated in pregnancy in comparison to non-pregnant women. Understanding maternal autonomic state not only improves our knowledge of gestational physiology but also forms the basis for the early detection of pregnancy complications associated with maternal autonomic dysfunction.
Next billion cameras (2009)

What will a camera look like 10 years from now? How should we change the camera to improve mobile photography? How will a billion networked and portable cameras change the social culture? How can we use bio-inspired processing to decompose sensed values into perceptually critical elements? How will online photo collections transform visual social computing?