gebhart/patrepeval huggingface dataset:
Complete amino acid sequence of canine miniplasminogen. (1989)

The complete amino acid sequence of ovine miniplasminogen (M(r) 37,662, 343 residues) was determined with the aid of fragments obtained by cleavage with 2-(2-nitrophenylsulfenyl)-3-methyl-3'-bromoindolenine and clostripain. The fragments were aligned with overlapping sequences and sequence comparison with miniplasminogens of other species. Sequence comparison with other species (human, bovine, porcine, equine and canine) gave an overall identity of 63% and a similarity of 83%. The dendrogram of the alignment indicates that ovine miniplasminogen has the closest relationship with the bovine (87% identity) and the most distant with the equine (77% identity) species. The close relationship is indicative for the presence of the same structural and functional domains as in the other species. Sequence comparison of different miniplasminogens showed that positions 49 (Arg), 83 (Arg) and 161 (Ser) in the light chain of the plasmin molecule may play a role in the interaction between plasminogen and streptokinase.
Tratamiento quir??rgico de las fracturas intertrocant??ricas de cadera con fracturas asociadas del cuello femoral utilizando una placa con tornillo deslizante (2005)

*Department of Orthopaedic Surgery, Hennepin County Medical Center, Minneapolis, MN; and †Department of Orthopaedics and Rehabilitation, Oregon Health & Sciences University, Portland, OR
A novel approach to touch voltage risk assessment for gas pipelines in shared transmission corridors (2022)

Abstract Touch voltages are more likely to appear on long‐distance pipelines that lie in shared corridors with transmission lines. The touch voltage level varies with soil resistivity and can become hazardous while maintenance is being undertaken, necessitating risk assessment. Therefore, a novel approach is proposed that achieves better accuracy in the risk assessment of hazardous touch voltages appearing on pipelines than current approaches. The proposed approach incorporates soil resistivity measurements taken over a 1‐year period, allowing for the derivation of soil models, touch voltage hazard profiles versus time and, thus, a probability reduction factor that can be integrated into a probabilistic risk calculation. Using a probability reduction factor is a key aspect to improving the accuracy of risk assessment, allowing pipeline asset operators to clearly identify whether or not, risk mitigation action is required. Further, the proposed approach allows appropriate risk mitigation actions to be identified. The efficacy and significance of the proposed approach are demonstrated through a case study on an area of land near a shared gas pipeline and transmission line corridor. The case study results show how appropriate safety levels can be achieved by adjusting the number of work day per year and temporary protection settings.
Neovascularization of the Optic Disc (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Ophthalmology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Ophthalmology journal
Optimization of multilayer integrated optics waveguides (1994)

A numerical method is described that provides the means for optimizing any objective function representing a general multilayer integrated optics waveguide. In this way, the physical parameters of the multilayer structure can be set so that the performance of the device is optimized. The method uses any standard numerical minimization algorithm in conjunction with the argument principle method. The method has been successfully applied for the optimization of a multilayer immunosensor and a TE-mode polarizer. The advantages of the method are its generality, its efficiency, its accuracy, and its applicability to a wide range of planar integrated optics devices.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Always-On Speech Recognition Using TrueNorth, a Reconfigurable, Neurosynaptic Processor (2016)

Deep neural networks (DNN) have been shown to be very effective at solving challenging problems in several areas of computing, including vision, speech, and natural language processing. However, traditional platforms for implementing these DNNs are often very power hungry, which has lead to significant efforts in the development of configurable platforms capable of implementing these DNNs efficiently. One of these platforms, the IBM TrueNorth processor, has demonstrated very low operating power in performing visual computing and neural network classification tasks in real-time. The neuron computation, synaptic memory, and communication fabrics are all configurable, so that a wide range of network types and topologies can be mapped to TrueNorth. This reconfigurability translates into the capability to support a wide range of low-power functions in addition to feed-forward DNN classifiers, including for example, the audio processing functions presented here.In this work, we propose an end-to-end audio processing pipeline that is implemented entirely on a TrueNorth processor and designed to specifically leverage the highly-parallel, low-precision computing primitives TrueNorth offers. As part of this pipeline, we develop an audio feature extractor (LATTE) designed for implementation on TrueNorth, and explore the tradeoffs among several design variants in terms of accuracy, power, and performance. We customize the energy-efficient deep neuromorphic networks structures that our design utilizes as the classifier and show how classifier parameters can trade between power and accuracy. In addition to enabling a wide range of diverse functions, the reconfigurability of TrueNorth enables re-training and re-programming the system to satisfy varying energy, speed, area, and accuracy requirements. The resulting system's end-to-end power consumption can be as low as <inline-formula><tex-math notation="LaTeX"> $14.43\text{mW}$</tex-math> </inline-formula> , which would give up to 100 hours of continuous usage with button cell batteries (CR3023 <inline-formula><tex-math notation="LaTeX">$1.5\; \text{Whr}$</tex-math></inline-formula> ) or 450 hours with cellphone batteries (iPhone 6s <inline-formula><tex-math notation="LaTeX">$6.55\; \text{Whr}$</tex-math></inline-formula> ).
Beyond the black box: event-based inter-process communication in process support systems (2003)

We describe the concept and implementation of an inter-process communication facility based on the exchange of events between concurrently running processes. In contrast to previous approaches based on shared data stored in a common database, our approach has the advantage of being platform independent and providing straightforward support for distribution. In addition, we also explore the problem of process atomicity and consistency when events are revoked due to the abort of processes. We present a family of recovery protocols that allow to control the effects of aborted processes.
A 553 K-transistor LISP processor chip (1987)

The authors describe a LISP microprocessor which includes over 550 K transistors, has 114 K of on-chip RAM, and runs instructions in a single 30-ns clock cycle. The chip is implemented in 1.25-/spl mu/m double-level-metal (DLM) CMOS, has 224 pins, and is packaged in a custom pin-grid array. The microinstruction and macroinstruction sets of this chip are compatible with an existing LISP processor. An extensive discussion of test features designed into the processor chip is given.
High-Speed Manipulation of Cells and Particles for Single-Cell Analysis and Mechanophenotyping (2012)

Due to the heterogeneity of cellular populations it is important to assay individual cells to garner an accurate representation of the system of interest, and oftentimes the cells which are most critical to detect are in a minority. High-throughput single-cell analysis methods, especially flow cytometry, possess this ability and have had a significant impact on the way many diseases are diagnosed and monitored and the way research in biology is performed. The frontiers of single-cell analysis lie in extending the accessibility of these methods to the point-of-care, where the cell manipulation strategies of traditional flow cytometry are ill-suited, and expanding upon the number and type of biomarkers which can be measured. This dissertation reports the development of new strategies for manipulating cells and particles in high-speed flows, a critical step toward meeting the needs of next-generation cytometric technologies. These strategies employ inertial phenomena present in finite Reynolds number confined flows to transfer cells and particles across laminar streamlines and perform operations on cells. Specifically, this dissertation reports the development of (1) a theoretical background and design criteria for inertial focusing at high Reynolds number, (2) a method for performing continuous rapid solution exchange around cells, and (3) a tool for assaying the mechanical properties of cells at a throughput comparable to flow cytometry (`deformability cytometry'). Generalized design rules, developed in the earlier work, were employed to develop tools for automated cellular sample preparation (`rapid inertial solution exchange') and to focus cells to ensure uniform hydrodynamic stretching in the deformability cytometry method and will be applicable to many future applications of inertial focusing for cytometry, imaging, and bead-based tools. Rapid inertial solution exchange will increase the accessibility of complicated assays to the point-of-care by increasing repeatability of cell-based protocols and minimizing labor-associated time and cost requirements while the label-free metrics provided by deformability cytometry stand in contrast to the variability and cost associated with label-based methods, and potentially extend the use of cytometric methods to new arenas and for more frequent and accurate monitoring of disease.
Critical Role of the NAD(P)H Oxidase Subunit p47 phox for Left Ventricular Remodeling/Dysfunction and Survival After Myocardial Infarction (2007)

Accumulating evidence suggests a critical role of increased reactive oxygen species production for left ventricular (LV) remodeling and dysfunction after myocardial infarction (MI). An increased myocardial activity of the NAD(P)H oxidase, a major oxidant enzyme system, has been observed in human heart failure; however, the role of the NAD(P)H oxidase for LV remodeling and dysfunction after MI remains to be determined. MI was induced in wild-type (WT) mice (n=46) and mice lacking the cytosolic NAD(P)H oxidase component p47(phox) (p47(phox)-/- mice) (n=32). Infarct size was similar among the groups. NAD(P)H oxidase activity was markedly increased in remote LV myocardium of WT mice after MI as compared with sham-operated mice (83+/-8 versus 16.7+/-3.5 nmol of O(2)(-) x microg(-1) x min(-1); P<0.01) but not in p47(phox)-/- mice after MI (13.5+/-3.6 versus 15.5+/-3.5 nmol of O(2)(-) x microg(-1) x min(-1)), as assessed by electron-spin resonance spectroscopy using the spin probe CP-H. Furthermore, increased myocardial xanthine oxidase activity was observed in WT, but not in p47(phox)-/- mice after MI, suggesting NAD(P)H oxidase-dependent xanthine oxidase activation. Myocardial reactive oxygen species production was increased in WT mice, but not in p47(phox)-/- mice, after MI. LV cavity dilatation and dysfunction 4 weeks after MI were markedly attenuated in p47(phox)-/- mice as compared with WT mice, as assessed by echocardiography (LV end-diastolic diameter: 4.5+/-0.2 versus 6.3+/-0.3 mm, P<0.01; LV ejection fraction, 35.8+/-2.5 versus 22.6+/-4.4%, P<0.05). Furthermore, cardiomyocyte hypertrophy, apoptosis, and interstitial fibrosis were substantially reduced in p47(phox)-/- mice as compared with WT mice. Importantly, the survival rate was markedly higher in p47(phox)-/- mice as compared with WT mice after MI (72% versus 48%; P<0.05). These results suggest a pivotal role of NAD(P)H oxidase activation and its subunit p47(phox) for LV remodeling/dysfunction and survival after MI. The NAD(P)H oxidase system represents therefore a potential novel therapeutic target to prevent cardiac failure after MI.
Cleavage of IgG1 in gingival crevicular fluid is associated with the presence of Porphyromonas gingivalis (2012)

In patients with periodontitis, cleavage of IgG1 occurs in vivo and may suppress antibody-dependent antibacterial activity in subgingival biofilms especially those colonized by Porphyromonas gingivalis.
Globally Convergent Dual MAP LP Relaxation Solvers using Fenchel-Young Margins (2012)

While finding the exact solution for the MAP inference problem is intractable for many real-world tasks, MAP LP relaxations have been shown to be very effective in practice. However, the most efficient methods that perform block coordinate descent can get stuck in sub-optimal points as they are not globally convergent. In this work we propose to augment these algorithms with an ɛ-descent approach and present a method to efficiently optimize for a descent direction in the subdifferential using a margin-based formulation of the Fenchel-Young duality theorem. Furthermore, the presented approach provides a methodology to construct a primal optimal solution from its dual optimal counterpart. We demonstrate the efficiency of the presented approach on spin glass models and protein interaction problems and show that our approach outperforms state-of-the-art solvers. 1
Thymidylate synthase expression predicts the response to 5-fluorouracil-based adjuvant therapy in pancreatic cancer. (2003)

High TS expression is a marker of poor prognosis in resected pancreatic cancer. Patients with high intratumoral TS expression benefit from adjuvant therapy.
Effect of Borehole Inclination, Annular Clearance, on the Hole Cleaning Efficiency for Water Based Drilling Muds (2010)

Effect of Borehole Inclination, Annular Clearance, on the Hole Cleaning Efficiency for Water Based Drilling Muds Mohamed N. Noui-Mehidi; Mohamed N. Noui-Mehidi EXPEC ARC Saudi Aramco Search for other works by this author on: This Site Google Scholar Mohamed Amanullah Mohamed Amanullah EXPEC ARC Saudi Aramco Search for other works by this author on: This Site Google Scholar Paper presented at the SPE/DGS Saudi Arabia Section Technical Symposium and Exhibition, Al-Khobar, Saudi Arabia, April 2010. Paper Number: SPE-136937-MS https://doi.org/10.2118/136937-MS Published: April 04 2010 Cite View This Citation Add to Citation Manager Share Icon Share Twitter LinkedIn Get Permissions Search Site Citation Noui-Mehidi, Mohamed N., and Mohamed Amanullah. "Effect of Borehole Inclination, Annular Clearance, on the Hole Cleaning Efficiency for Water Based Drilling Muds." Paper presented at the SPE/DGS Saudi Arabia Section Technical Symposium and Exhibition, Al-Khobar, Saudi Arabia, April 2010. doi: https://doi.org/10.2118/136937-MS Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll ProceedingsSociety of Petroleum Engineers (SPE)SPE Kingdom of Saudi Arabia Annual Technical Symposium and Exhibition Search Advanced Search Abstract In the case of deviated, horizontal, extended reach and multi-lateral wells, the existence of a particle bed and also the formation of a partially or completely buried cuttings bed can be problematic for borehole cleaning. As a solution increasing the drilling fluid velocity can help in eroding the deposited bed substantially above a critical velocity, which depends on several flow parameters. For instance pipe rotational speed can enhance particle transportation at flow velocities lower than the critical annular fluid velocities as reported in the literature. The consequences of pipe rotation on the fluid transport ability are also subject to the inclination of the drilled section. The present paper discusses the results of numerical simulations of water based drilling fluid flows regarding the inclination effect, the fluid viscosity, the clearance between the pipe and the borehole and the resulting pressure losses. Keywords: society of petroleum engineers, null null, bypass flow, upstream oil & gas, production logging, axial flow, drilling fluids and materials, ohmura, null null null null, borehole Subjects: Pressure Management, Drilling Fluids and Materials, Well & Reservoir Surveillance and Monitoring, Wellbore pressure management, Production logging Copyright 2010, Society of Petroleum Engineers You can access this article if you purchase or spend a download.
On the concept of a normal metal hot-electron microbolometer for space applications (1999)

We present a theoretical analysis and experimental evaluation of a hot-electron microbolometer with normal metal absorber for ultrasensitive detecting infrared and submillimeter waves. The basic version of the antenna coupled microbolometer makes use of a hot-electron effect in the thin film resistive strip and Andreev reflection of hot electrons at SN interface between the strip and superconducting antenna. A value of NEP=5/spl middot/10/sup -18/ W/Hz/sup 1/2/ for the thermal fluctuation noise and the thermal time constant t=0.2 /spl mu/s at 300 mK have been estimated for one of the realized devices with thermal conductance G/spl ap/6/spl middot/10/sup -12/ W/K. At 100 mK, the thermal conductance has been decreased to G/spl ap/7/spl middot/10/sup -14/ W/K, that gives estimations for the thermal NEP=2/spl middot/10/sup -19/ W/Hz/sup 1/2/ and the time constant t=5 /spl mu/s. An advanced version of the microbolometer includes also additional SIN junctions connected to the resistive strip for electronic cooling the absorber. Such microbolometer is intended as a detector of millimeter and submillimeter wave radiation for space applications.
Exact temporal eddy current compensation in magnetic resonance imaging systems (1988)

A step-response method has been developed to extract the properties (amplitudes and decay time constants) of intrinsic-eddy-current-sourced magnetic fields generated in whole-body magnetic resonance imaging systems when pulsed field gradients are applied. Exact compensation for the eddy-current effect is achieved through a polynomial rooting procedure and matrix inversion once the 2 N properties of the N-term decay process are known. The output of the inversion procedure yields the required characteristics of the filter for spectrum magnitude and phase equalization. The method is described for the general case along with experimental results for one-, two-, and three-term inversions. The method's usefulness is demonstrated for the usually difficult case of long-term (200-1000-ms) eddy-current compensation. Field-gradient spectral flatness measurements over 30 mHz-100 Hz are given to validate the method.
The “η-sweet-spot” (ηmax) in liquid-assisted mechanochemistry: polymorph control and the role of a liquid additive as either a catalyst or an inhibitor in resonant acoustic mixing (RAM) (2022)

Resonant acoustic mixing (RAM) offers a simple, efficient route for mechanochemical synthesis in the absence of milling media or bulk solvents. Here, we show the use of RAM to conduct the copper-catalysed coupling of sulfonamides and carbodiimides. This coupling was previously reported to take place only by mechanochemical ball milling, while in conventional solution environments it is not efficient, or does not take place at all. The results demonstrate RAM as a suitable methodology to conduct reactions previously accessed only by ball milling and provide a detailed, systematic overview of how the amount of liquid additive, measured by the ratio of liquid volume to weight of reactants (<i>η</i>, in μL mg<sup>-1</sup>), can affect the course of a mechanochemical reaction and the polymorphic composition of its product. Switching from ball milling to RAM allowed for the discovery of a new polymorph of the model sulfonylguanidine obtained by catalytic coupling of di(cyclohexyl)carbodiimide (DCC) and <i>p</i>-toluenesulfonamide, and the ability to control reaction temperature in RAM enabled <i>in situ</i> control of the polymorphic behaviour of this nascent product. We show that the reaction conversion for a given reaction time does not change monotonically but, instead, achieves a maximum for a well-defined <i>η</i>-value. This "<i>η</i>-sweet-spot" of conversion is herein designated <i>η</i><sub>max</sub>. The herein explored reactions demonstrate sensitivity to <i>η</i> on the order of 0.01 μL mg<sup>-1</sup>, which corresponds to an amount of liquid additive below 5 mol% compared to the reactants, and is at least one to two orders of magnitude lower than the <i>η</i>-value typically considered in the design of liquid-assisted ball milling mechanochemical reactions. Such sensitivity suggests that strategies to optimise liquid-assisted mechanochemical reactions should systematically evaluate <i>η</i>-values at increments of 0.01 μL mg<sup>-1</sup>, or even finer. At <i>η</i>-values other than <i>η</i><sub>max</sub> the reaction conversion drops off, demonstrating that the same liquid additive can act either as a catalyst or an inhibitor of a mechanochemical reaction, depending on the amount.
157-nm single-layer resists based on advanced fluorinated polymers (2002)

Various polymer structures for 157-nm lithography have been vigorously developed for post 193-nm lithography. Polymers with a fluorinated main chain can improve high transparency at the 157-nm wavelength; conversely, norbornene copolymers with fluoride pendant groups do not achieve so high transparency at the 157-nm wavelength. We have developed a novel 157-nm chemically amplified resist. It is composed of a fluorinated monocyclic main-chain polymer, which shows high transparency and can be used for single layer resists. This new resist is referred to as a Small Absorbance Fluorine contAining ResIst (SAFARI). The SAFARI resist exhibited high-resolution patterns of 65-nm line and space patterns using a 0.85 NA microstepper, good sensitivity of 4 mJ/cm<SUP>2</SUP>, and high transparency when applied to 250-nm film thickness.
ChemInform Abstract: Li2CaSi2N4 and Li2SrSi2N4 — A Synthetic Approach to Three‐Dimensional Lithium Nitridosilicates. (2011)

Abstract The new title compounds are synthesized from mixtures of Li, Si(NH) 2 , LiN 3 , and Ca or Sr using excess Li as flux (Ta crucible, 900 °C, 24 h).