gebhart/patrepeval huggingface dataset:
Registration of High‐Methionine Versions of Maize Inbreds A632, B73, and Mo17 (2008)

Maize ( Zea mays L.) is a primary energy‐supplying grain for animal feed in the United States. However, it is deficient in the essential amino acid methionine. Of the maize used for animal feed, 20% is fed to poultry, where the methionine requirement is particularly important. Significant increases in maize methionine levels in the lines reported here can be effectively used in poultry nutrition as well as in human diets where corn and bean ( Phaseolus L.) play a major role. Eleven inbred lines of high‐methionine maize (58611 Inbred A632 [Reg. No. GP‐557, PI 648423], 58609 A632 (Meth) BC5S4 [Reg. No. GP‐558, PI 648424], 58610 A632 (Meth) BC5S4 [Reg. No. GP‐559, PI 648425], 58612 Inbred B73 [Reg. No. GP‐560, PI 648426], 58613 B73 (Meth) BC5S4 [Reg. No. GP‐561, PI 648427], 58614 B73 (Meth) BC5S4 [Reg. No. GP‐562, PI 648428], 58615 B73 (Meth) BC5S4 [Reg. No. GP‐563, PI 648429], 58801 Inbred Mo17 [Reg. No. GP‐564, PI 648430], 58802 Mo17 (Meth) BCS3 [Reg. No. GP‐565, PI 648431], 58803 Mo17 (Meth) BCS3 [Reg. No. GP‐566, PI 648432], and 58804 Mo17 (Meth) BCS3 [Reg. No. GP‐567, PI 648433]) were developed by the University of Minnesota and released on 26 Oct. 2007 by the Minnesota Agricultural Experimental Station. These materials were produced by crossing BSSS53 with inbred lines A632, B73, and Mo17 and backcrossing to the respective inbred with intermittent selfing. Maize inbred lines A632, B73, and Mo17 are released with methionine elevated as much as 12.5, 25.0, and 50.0%, respectively, above the recurrent parent. The germplasm source of the high methionine trait is a random line isolate from the Iowa Stiff Stalk Synthetic, identified as BSSS53 and later released by the Iowa State Experiment Station as B101 after obtaining the high methionine information from the University of Minnesota.
Erratum: Structure and electronic properties of cerium orthophosphate: Theory and experiment [Phys. Rev. B83, 205104 (2011)] (2012)

In Fig. This should be the Ce 5s peak. This typographical error does not affect our results reported in the original paper.
ChemInform Abstract: Regioselective Alkylation of Phenol with Cyclopentanol over Montmorillonite K10: An Efficient Synthesis of 1‐(2‐Cyclopentylphenoxy)‐3‐[(1,1‐dimethylethyl)amino]propan‐2‐ol {(S)‐Penbutolol}. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Production of superplastic Ti–6Al–7Nb alloy using high-pressure sliding process (2018)

A Ti–6Al–7Nb alloy was processed by severe plastic deformation through high-pressure sliding (HPS) at room temperature for grain refinement. The microstructure consists of grains with sizes of 100–200 nm in diameter having high and low angles boundaries. Superplasticity appeared with the total elongation of more than 400% and this was more likely when the tensile specimen is deformed in the direction parallel than perpendicular to the sliding direction. However, the superplastic elongation is almost the same irrespective of whether the sliding was made in the single direction or in the reversible directions as far as the total sliding distance is the same. The total elongation is invariably higher for the tensile testing at 1123 K than at the other temperatures, reaching the highest elongation of 790% at the initial strain rate of 1×10−3 s−1. The strain rate sensitivity and the activation energy for the deformation were determined to be more than ～0.3 and 200 kJ/mol, respectively. The microstructural observation reveals that the α phase region covers more than 85% of the tensile specimens after deformation and their grains are equiaxed in shape. It is concluded that the superplastic deformation is mainly controlled by grain boundary sliding through thermally activation by lattice diffusion.
A direct approach to time-varying modelling (1987)

We consider the on-line identification of continuously adaptive autoregressive (AR) models for observed data records which are realizations of non-stationary stochastic processes. Emphasis is placed on the treatment of arbitrary non-stationarities and the use of realistic assumptions in this operation. Because of these two objectives, usual adaptation procedures or description techniques are not well suited to the problem, which motivates the investigation of a new (direct) approach to time-varying parameter estimation. The cost criterion considered is a constrained least squares cost functional which incorporates with equal weight all instantaneous errors up to the current time of observation. The constraint is specified from limited a priori knowledge about the nature of the non-stationarity, namely the expected maximum rate of change (MRC) of the model parameters.
Sequence‐Specific Nucleic Acid Damage Induced by Peptide Nucleic Acid Conjugates That Can Be Enzyme‐Activated (2006)

Mitarbeiter gesucht: Ein Konjugat aus einer 12meren Peptidnucleinsäure (PNA) und Flavin wird mit der zur PNA-Einheit komplementären Sequenz in einem 25meren Oligo-2′-desoxyribonucleotid hybridisiert, und nun kann die Flavineinheit eine NADPH:Flavin-Oxidoreduktase „anwerben“. Mithilfe dieses Komplexes kann molekularer Sauerstoff in Gegenwart von NADH aktiviert und das Oligonucleotid-Zielmolekül selektiv oxidiert werden (siehe Schema).
Growth of GaN by MOCVD on Rare Earth Oxide on Si(111) (2013)

Growth of GaN on rare earth oxide (REO) buffers grown on silicon (111) was performed. A novel low temperature buffer layer was developed in order to suppress the decomposition of the REO buffer under hydrogen flow during MOCVD. GaN films, grown by this technique, exhibit smooth surface morphologies. XRD studies reveal the formation of an ErN layer during growth.
Rapid assessment of SARS-CoV-2–evolved variants using virus-like particles (2021)

Efforts to determine why new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants demonstrate improved fitness have been limited to analyzing mutations in the spike (S) protein with the use of S-pseudotyped particles. In this study, we show that SARS-CoV-2 virus-like particles (SC2-VLPs) can package and deliver exogenous transcripts, enabling analysis of mutations within all structural proteins and at multiple steps in the viral life cycle. In SC2-VLPs, four nucleocapsid (N) mutations found universally in more-transmissible variants independently increased messenger RNA delivery and expression ~10-fold, and in a reverse genetics model, the serine-202→arginine (S202R) and arginine-203→methionine (R203M) mutations each produced >50 times as much virus. SC2-VLPs provide a platform for rapid testing of viral variants outside of a biosafety level 3 setting and demonstrate N mutations and particle assembly to be mechanisms that could explain the increased spread of variants, including B.1.617.2 (Delta, which contains the R203M mutation).
Robert W. Lenz (2011)

ADVERTISEMENT RETURN TO ISSUEPREVTributeNEXTRobert W. LenzChristopher K. OberView Author Information Cornell UniversityCite this: Macromolecules 2011, 44, 7, 1731Publication Date (Web):March 1, 2011Publication History Published online1 March 2011Published inissue 12 April 2011https://pubs.acs.org/doi/10.1021/ma200130phttps://doi.org/10.1021/ma200130pobituaryACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views611Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Polymer chemistry,Polymer science,Polymers Get e-Alerts
学习竹轮理惠小姐的化妆技巧，让你从今天起变身眉美人：秋季的美丽妆容眉毛是关键！ (2006)

女性的妆容随着时代的变行发生了千变万化。追随时代关注整个妆容，脸部中唯一能改变形状的眉毛其变化最大，可以说只是改变眉毛的形状就可以描画出符合该时代的妆容。而且眉毛可以说是整个美人妆中最重要的部分。
Hoxb8 Intersection Defines a Role forLmx1bin Excitatory Dorsal Horn Neuron Development, Spinofugal Connectivity, and Nociception (2015)

Spinal cord neurons respond to peripheral noxious stimuli and relay this information to higher brain centers, but the molecules controlling the assembly of such pathways are poorly known. In this study, we use the intersection of Lmx1b and Hoxb8::Cre expression in the spinal cord to genetically define nociceptive circuits. Specifically, we show that Lmx1b, previously shown to be expressed in glutamatergic dorsal horn neurons and critical for dorsal horn development, is expressed in nociceptive dorsal horn neurons and that its deletion results in the specific loss of excitatory dorsal horn neurons by apoptosis, without any effect on inhibitory neuron numbers. To assess the behavioral consequences of Lmx1b deletion in the spinal cord, we used the brain-sparing driver Hoxb8::Cre. We show that such a deletion of Lmxb1 leads to a robust reduction in sensitivity to mechanical and thermal noxious stimulation. Furthermore, such conditional mutant mice show a loss of a subpopulation of glutamatergic dorsal horn neurons, abnormal sensory afferent innervations, and reduced spinofugal innervation of the parabrachial nucleus and the periaqueductal gray, important nociceptive structures. Together, our results demonstrate an important role for the intersection of Lmx1b and Hoxb8::cre expression in the development of nociceptive dorsal horn circuits critical for mechanical and thermal pain processing.
Faculty Opinions recommendation of Identification of a 3.0-kb major recombination hotspot in patients with Sotos syndrome who carry a common 1.9-Mb microdeletion. (2004)

Sotos syndrome (SoS) is a congenital dysmorphic disorder characterized by overgrowth in childhood, distinctive craniofacial features, and mental retardation. Haploinsufficiency of the NSD1 gene owing to either intragenic mutations or microdeletions is known to be the major cause of SoS. The common approximately 2.2-Mb microdeletion encompasses the whole NSD1 gene and neighboring genes and is flanked by low-copy repeats (LCRs). Here, we report the identification of a 3.0-kb major recombination hotspot within these LCRs, in which we mapped deletion breakpoints in 78.7% (37/47) of patients with SoS who carry the common microdeletion. The deletion size was subsequently refined to 1.9 Mb. Sequencing of breakpoint fragments from all 37 patients revealed junctions between a segment of the proximal LCR (PLCR-B) and the corresponding region of the distal LCR (DLCR-2B). PLCR-B and DLCR-2B are the only directly oriented regions, whereas the remaining regions of the PLCR and DLCR are in inverted orientation. The PLCR, with a size of 394.0 kb, and the DLCR, with a size of of 429.8 kb, showed high overall homology (approximately 98.5%), with an increased sequence similarity (approximately 99.4%) within the 3.0-kb breakpoint cluster. Several recombination-associated motifs were identified in the hotspot and/or its vicinity. Interestingly, a 10-fold average increase of a translin motif, as compared with the normal distribution within the LCRs, was recognized. Furthermore, a heterozygous inversion of the interval between the LCRs was detected in all fathers of the children carrying a deletion in the paternally derived chromosome. The functional significance of these findings remains to be elucidated. Segmental duplications of the primate genome play a major role in chromosomal evolution. Evolutionary study showed that the duplication of the SoS LCRs occurred 23.3-47.6 million years ago, before the divergence of Old World monkeys. PMID: 15580547
AN ANATOMICAL STUDY OF MENISCAL ALLOGRAFT SIZING. (2004)

Introduction: Accurate size-matching of meniscal allografts is essential to maintain tibiofemoral congruity, and therefore function, especially when the surgical technique of using a bony bridge is employed. Methods of accurately assessing the required dimensions of an ideal meniscal allograft for each patient are limited. One popular method used is to choose the appropriate graft according to the bony tibial plateau dimensions of the patient, as determined from plain radiographs. Aims: To correlate meniscal dimensions with the bony dimensions of donor tibial plateaus. Methods: 22 left and right pairs of donor tibial plateaus with intact meniscal allografts were obtained, giving a total of 88 individual meniscal allografts. Using a digital micrometer, the following meniscal dimensions were measured: anteroposterior length, medial-lateral width, and the radial width at the mid-point of the meniscal body. Peripheral circumference was measured using flexible steel wire. Medial and lateral bony tibial plateau width and length, and total plateau width were also recorded. Linear regression analysis was used to obtain a formula, relating each meniscal dimension to the various bony plateau measurements. The resulting equations were used to calculate an expected meniscal dimension from the measured plateau dimensions, and this was compared to the size of the actual dimension measured. Results: The magnitude of the meniscal dimensions measured approximately fitted a normal distribution amongst all the specimens studied. The tibial plateau widths ranged from 69.2mm to 88.4mm (mean 78.5mm, s.d. 5.4mm), a 28% difference. The mean difference between meniscal measurements between the left and right knee of each pair was 7.3%. However, the greatest individual difference observed was 41.8%. The mean percentage error between meniscal dimensions calculated from specific compartmental tibial plateau dimensions, and the actual measured meniscal dimensions was 5.3% (s.d. 4.1%). When using just total bony tibial plateau width to calculate meniscal dimensions, the percentage error was 6.2% (s.d. 4.9%). This difference was not statistically significant. The maximum error between calculated and actual meniscal dimensions was 32%. Conclusions: This anatomical study shows that the use of plateau dimensions as a determinant for the sizing of meniscal allografts can be used to predict meniscal dimensions. However, mean errors are in the region of 5% – 6%, and can be as high as 32%. The potential mechanical effects of such graft to host size mismatching must be carefully borne in mind.
Capacitation‐associated changes in membrane fluidity in asthenozoospermic human spermatozoa (2008)

The fertilizing potential of human spermatozoa relies on their ability to capacitate as they travel through the female reproductive tract. During this process, cholesterol is released from the plasma membrane, altering its architecture and dynamics. Using ISolate gradients, we obtained high (L90)- and low (L45)-quality spermatozoa from asthenozoospermic human semen samples. We tested the hypothesis that the lower fertilizing ability of asthenozoospermic L90 cells could be related to a lower ability to increase their membrane fluidity during capacitation. We assessed two sets of fluorescent probes: (i) DPH, TMA-DPH and PA-DPH which senses the hydrophobic core, cytosolic and exofacial leaflets of the bilayer, respectively and (ii) Laurdan, sensitive to the amount of water molecules intercalated between lipid moieties of the membrane (membrane hydration). Before capacitation, membrane fluidity of asthenozoospermic sperm populations was similar to the corresponding fractions of normozoospermic cells when evaluated with DPH, TMA-DPH or PA-DPH. Asthenozoospermic whole samples displayed lower plasma membrane hydration than normozoospermic cells as evidenced with Laurdan. After capacitation, asthenozoospermic L45 and L90 cells failed to increase their membrane fluidity in opposition to normozoospermic cells. Interestingly, membrane hydration significantly correlated with the main sperm motion parameters analysed, being a low membrane hydration associated with poor sperm movement. These results show that low-motility spermatozoa are unable to respond to capacitation with the necessary changes in membrane fluidity. This defect in sperm plasma membrane rheology may be responsible for their poor functional quality and low fertilizing ability.
Rapid reductions in prices for generic sofosbuvir and daclatasvir to treat hepatitis C (2016)

The costs of generic production of sofosbuvir and daclatasvir are rapidly decreasing. Sofosbuvir-daclatasvir combination treatment could be produced for US$200 per patient per 12-week course.
Light damage in the developing retina of the albino rat: an electroretinographic study. (1986)

The albino rat retina is severely damaged by exposure to bright light. The degree of damage depends upon the intensity of the exposure and its duration. In the present study, electroretinographic (ERG) responses were measured in rats exposed at different ages during the period of retinal development to 24 hr of bright light and then transferred to darkness for about 2 months. The ERG data indicated that if the bright-light exposure was done prior to 20 days of age, the retina was resistant to the light damage, and the dark-adapted ERG responses measured later were normal. In rats older than 20 days, light damage increased with age until, in rats exposed to light at age 30 days, the ERG was unrecordable. Further experiments showed that light exposure did damage the 15-day-old rat retina; however, complete recovery was attained within 15 days postexposure.
Double-layer silicon waveguides in standard silicon for 3D photonics (2013)

We demonstrate a 3D photonic technology for fabrication of double-layer silicon waveguides in standard silicon. This technology eliminates the need for silicon-on-insulator (SOI) wafers and can be further expanded to multiple-layer photonics for different applications.
Supplementary Table S1 from Sex Differences in Cancer Driver Genes and Biomarkers (2023)

&lt;p&gt;Description of CNA and SNV data, pancancer and tumour type-specific model variables, and summary of variables for each tumour type&lt;/p&gt;
Nasogastric tube insertion using flexible fibreoptic nasendoscope (2001)

The insertion of a nasogastric tube, especially a fine bore feeding tube, can occasionally be problematic because of an anatomical variation or pathology. A method of passing an nasogastric tube under direct vision using a flexible fibreoptic nasoendoscope introduced through the nostril is described, which is reserved for cases where traditional methods of insertion failed.
Regioselective Opening of myo-Inositol Orthoesters: Mechanism and Synthetic Utility (2013)

Acid hydrolysis of myo-inositol 1,3,5-orthoesters, apart from orthoformates, exclusively affords the corresponding 2-O-acyl myo-inositol products via a 1,2-bridged five-membered ring dioxolanylium ion intermediate observed by NMR spectroscopy. These C-2-substituted inositol derivatives provide valuable precursors for rapid and highly efficient routes to 2-O-acyl inositol 1,3,4,5,6-pentakisphosphates and myo-inositol 1,3,4,5,6-pentakisphosphate with biologically interesting and anticancer properties. Deuterium incorporation into the α-methylene group of such alkyl ester products (2-O-C(O)CD2R), when the analogous alkyl orthoester is treated with deuterated acid, is established utilizing the novel orthoester myo-inositol 1,3,5-orthobutyrate as an example. Such deuterated ester products provide intermediates for deuterium-labeled synthetic analogues. Investigation into this selective formation of 2-O-ester products and the deuterium incorporation is presented with proposed mechanisms from NMR experiments.
Using Information Invariants to Compare Swarm Algorithms and General Multi-Robot Algorithms (2018)

Robotic swarms are decentralized multi-robot systems whose members use local information from proximal neighbors to execute simple reactive control laws that result in emergent collective behaviors. In contrast, members of a general multi-robot system may have access to global information, all-to-all communication or sophisticated deliberative collaboration. Some algorithms in the literature are applicable to robotic swarms. Others require the extra complexity of general multi-robot systems. Given an application domain, a system designer or supervisory operator must choose an appropriate system or algorithm respectively that will enable them to achieve their goals while satisfying mission constraints (e.g, bandwidth, energy, time limits). In this paper, we compare representative swarm and general multi-robot algorithms in two application domains - navigation and dynamic area coverage - with respect to several metrics (e.g, completion time, distance travelled). Our objective is to characterize each class of algorithms to inform offline system design decisions by engineers or online algorithm selection decisions by supervisory operators. Our contributions are (a) an empirical performance comparison of representative swarm and general multi-robot algorithms in two application domains, (b) a comparative analysis of the algorithms based on the theory of information invariants, which provides a theoretical characterization supported by our emnirical results.
Digital Optics Application Pools (2009)

This chapter contains sections titled: Heavy Industry Defense, Security and Space Clean Energy Factory Automation Optical Telecoms Biomedical Applications Entertainment and Marketing Consumer Electronics Summary The Future of Digital Optics
Blood Glucose Dependence on Emotional Behaviors and Body Surface Temperatures in Common Marmoset’s Socio-Psychological Learning with Peers - for ‘Development of Human-Environment Interface by Sensing and Multivariate Analysis of Bio-Ecosystem’ - (2013)

It is urgent issue to introduce re-usable energy system, low carbon resources, and food production system compatible with natural environment and we should find an optimized solution in an economic society. “Smart environment” is one of the solutions. The smart environment is expected to optimize a balance of well-being versus energy cost. However, we have no idea what is the best optimization and how to optimize the balance. Here, we attempted to develop a bio-eco system which is able to sense human behavior and physiological response under certain environment to automatically regulate environment to realize a balance which improves human health with minimum energy cost. We describe an information processing model accompanied with the multi-parametric visualization of social interaction behavior in animals and humans based on mainly principal component analysis. For this application in primates, we analyzed their psychological lifelong development to find any susceptible period to environments which is critical to confer their lifelong adaptability to environment. In the study, we could confirm usefulness of blood glucose sensing to infer developmental stages.
Synthesis of an RGD‐Sialyl‐LewisX Glycoconjugate: A New Highly Active Ligand for P‐Selectin** (1995)

Complex saccharide-peptide conjugates are accessible through an efficient fragment condensation in which the partially protected RGD peptide is coupled with the sialyl LewisX amine unit to form 1. Compound 1 is the most potent antagonist for P-select-in yet reported.