gebhart/patrepeval huggingface dataset:
Abstract IA10: Structure and dynamics of Rag heterodimers in a complex with mTORC1 (2020)

Abstract Eukaryotic cells coordinate growth with the availability of nutrients through the protein kinase complex mTORC1, which is part of a pathway that is often upregulated in cancer. The mTORC1 complex is activated by association with two types of GTPases, Rags and RHEB. The heterodimeric Rag GTPases are key components in the activation of the mTORC1 pathway in response to amino acids. The Rag heterodimer interacts with the RAPTOR subunit of mTORC1 in a manner dependent on the nucleotide-bound states of its constituent GTPases. We used hydrogen/deuterium exchange mass spectrometry (HDX-MS) to map the interface of RAPTOR with an active Rag heterodimer, and we determined X-ray crystal structures of human Rag heterodimers in several nucleotide-bound states. Our high-resolution crystal structure of an oncogenic mutant heterodimer enabled us to interpret the cryo-EM structure of a complex of mTORC1 with the mutant RagA/C heterodimer. The cryo-EM structure shows that the G-domains from both Rags contact helical repeats of the RAPTOR subunit of mTORC1, but the GTP-bound RagA G domain forms almost all of the interface. The structure suggests how the nucleotide state of RagA is coordinated with the nucleotide state of RagC. The conformation of mTORC1 in a complex with the Rags is nearly identical to the apo mTORC1 complex, suggesting that the primary role of Rag binding is to recruit the mTORC1 complex to the lysosomal surface in the presence of the Ragulator complex. Citation Format: Madhan Anandapadamanaban, Olga Perisic, Alex Berndt, Glenn R Masson, Jonathan Kaufman, Stephen H. McLaughlin, Chris M. Johnson, David M. Sabatini, Roger L. Williams. Structure and dynamics of Rag heterodimers in a complex with mTORC1 [abstract]. In: Proceedings of the AACR Special Conference on Targeting PI3K/mTOR Signaling; 2018 Nov 30-Dec 8; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Res 2020;18(10_Suppl):Abstract nr IA10.
EFFECT OF METALLOCENE POLYETHYLENE ON HEAT SEALING PROPERTIES OF LOW DENSITY POLYETHYLENE BLENDS (2000)

Laminations made with blends of metallocene polyethylene (m-PE) and high-pressure low density polyethylene (LDPE) were prepared to investigate the effect of the former resin on heat sealing performance. According to various experimental studies of seal strength, hot tack and differential scanning calorimeter (DSC), it could be concluded that percentages around 15% of m-PE allow the obtainment of the optimal balance for heat sealing properties and cost. Using the interdiffusion theory of heat sealing, a thorough discussion of the results was done.
Detectors (2004)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Mehmet Bayindir, Ayman F. Abouraddy, Fabien Sorin, John D. Joannopoulos, and Yoel Fink, "Detectors," Optics & Photonics News 15(12), 24-24 (2004) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Emerging Promise of Cannabinoids for the Management of Pain and Associated Neuropathological Alterations in Alzheimer’s Disease (2020)

Alzheimer's disease (AD) is an irreversible chronic neurodegenerative disorder that occurs when neurons in the brain degenerate and die. Pain frequently arises in older patients with neurodegenerative diseases including AD. However, the presence of pain in older people is usually overlooked with cognitive dysfunctions. Most of the times dementia patients experience moderate to severe pain but the development of severe cognitive dysfunctions tremendously affects their capability to express the presence of pain. Currently, there are no effective treatments against AD that emphasize the necessity for increasing research to develop novel drugs for treating or preventing the disease process. Furthermore, the prospective therapeutic use of cannabinoids in AD has been studied for the past few years. In this regard, targeting the endocannabinoid system has considered as a probable therapeutic strategy to control several associated pathological pathways, such as mitochondrial dysfunction, excitotoxicity, oxidative stress, and neuroinflammation for the management of AD. In this review, we focus on recent studies about the role of cannabinoids for the treatment of pain and related neuropathological changes in AD.
Structural Basis for Sequence-specific DNA Recognition by an Arabidopsis WRKY Transcription Factor (2012)

The WRKY family transcription factors regulate plant-specific reactions that are mostly related to biotic and abiotic stresses. They share the WRKY domain, which recognizes a DNA element (TTGAC(C/T)) termed the W-box, in target genes. Here, we determined the solution structure of the C-terminal WRKY domain of Arabidopsis WRKY4 in complex with the W-box DNA by NMR. A four-stranded β-sheet enters the major groove of DNA in an atypical mode termed the β-wedge, where the sheet is nearly perpendicular to the DNA helical axis. Residues in the conserved WRKYGQK motif contact DNA bases mainly through extensive apolar contacts with thymine methyl groups. The importance of these contacts was verified by substituting the relevant T bases with U and by surface plasmon resonance analyses of DNA binding.
Tropical fruit wastes including durian seeds and rambutan peels as a precursor for producing activated carbon using H 3 PO 4 -assisted microwave method: RSM-BBD optimization and mechanism for methylene blue dye adsorption (2023)

Herein, tropical fruit biomass wastes including durian seeds (DS) and rambutan peels (RP) were used as sustainable precursors for preparing activated carbon (DSRPAC) using microwave-induced H<sub>3</sub>PO<sub>4</sub> activation. The textural and physicochemical characteristics of DSRPAC were investigated by N<sub>2</sub> adsorption-desorption isotherms, X-ray diffraction, Fourier transform infrared, point of zero charge, and scanning electron microscope analyses. These findings reveal that the DSRPAC has a mean pore diameter of 3.79 nm and a specific surface area of 104.2 m<sup>2</sup>/g. DSRPAC was applied as a green adsorbent to extensively investigate the removal of an organic dye (methylene blue, MB) from aqueous solutions. The response surface methodology Box-Behnken design (RSM-BBD) was used to evaluate the vital adsorption characteristics, which included (A) DSRPAC dosage (0.02-0.12 g/L), (B) pH (4-10), and (C) time (10-70 min). The BBD model specified that the DSRPAC dosage (0.12 g/L), pH (10), and time (40 min) parameters caused the largest removal of MB (82.1%). The adsorption isotherm findings reveal that MB adsorption pursues the Freundlich model, whereas the kinetic data can be well described by the pseudo-first-order and pseudo-second-order models. DSRPAC exhibited good MB adsorption capability (118.5 mg/g). Several mechanisms control MB adsorption by the DSRPAC, including electrostatic forces, π-π stacking, and H-bonding. This work shows that DSRPAC derived from DS and RP could serve as a viable adsorbent for the treatment of industrial effluents containing organic dye.
SPC04-5: Practical Channel Estimation for OFDM in time-varying channels (2006)

In fast mobile environments, the reception of orthogonal frequency domain modulation (OFDM) signals with tight sub-carrier spacing is challenged by the inter-carrier interference (ICI). This ICI must be compensated for by a suitable equalizer design, which requires the estimation of a larger number of parameters than for static environments. In addition, ICI also degrades the quality of the channel estimation. We propose an analytical approach to estimate the frequency domain channel matrix that relies on its nearly banded structure and a first order Taylor approximation of the channel variation. An additional constraint of this work is to accommodate OFDM systems with large number of sub-carriers and scattered pilots, such as used in DVB-T and DVB-H broadcast. We provide simulation results to demonstrate the performance of the proposed channel estimation method.
ChemInform Abstract: Ketone Homologation to Produce α‐Methoxyketones: Application to Conduritol Synthesis. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Recursos de cooperativas que levam à vantagem competitiva sustentável (2016)

O objetivo desta pesquisa é analisar como os recursos organizacionais contribuem para as cooperativas alcançarem vantagem competitiva sustentável. Este estudo tem uma abordagem teórica da Visão Baseada em Recursos e o modelo VRIO preconizado por Barney e Hesterly (2007). A pesquisa caracterizou-se como descritiva e quantitativa, através da coleta de dados por fontes secundárias e survey. O instrumento de coleta foi o questionário de Pavão, Sehnem e Hoffmann (2011). A coleta dos dados ocorreu no período dos meses de Setembro de 2014 a Março de 2015. Um total de 215 cooperativas do território nacional distribuídas em 13 segmentos compuseram a amostra da pesquisa. Com os dados secundários foi realizada a análise de conteúdo. Os dados primários foram analisados por meio de inferência estatística, quais sejam: estatística descritiva, média, correlação de Pearson, rotação Varimax e teste de Kruskal-Wallis. Como principais resultados obtidos, observou-se que o recurso humano é visto como importante para o alcance de vantagem competitiva sustentável. A presente pesquisa contribuiu e possibilita novos estudos referente ao crescimento das cooperativas levando em consideração a utilização dos recursos internos possam ser realizados.
The effect of crystallinity of HfO<inf>2</inf> on the resistive memory switching reliability (2011)

We measured direct physical evidence that can explain different switching behaviors for HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> based ReRAM structure for the first time. The switching behavior depends on the degree of crystallinity of HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> . We observed crystallized HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> which is grown under higher temperature with High Resolution Scanning Transmission Electron Microscopy (STEM) Electron Energy Loss Spectroscopy (EELS), which prevents creating enough oxygen vacancies to start electric switching under low forming voltage. However, non-stoichiometric structure region of HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> which has amorphous phase provides enough oxygen vacancies which are the electrical paths. Therefore, non-stoichiometric structure of amorphous HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> during fabricating process is crucial to obtain reliable switching characteristics.
Power Line Communication for Low-Bandwidth Control and Sensing (2021)

While not designed with communication applications in mind, power lines have been attractive targets for providing ancillary communication services for decades. Unfortunately, loads and switchgear can easily interfere with reliable communication in both direct and subtle ways. Power line communication (PLC) is therefore often relegated to non-critical control tasks like home lighting or appliance control, where communication difficulties or failure simply result in a walk to the light switch. For control applications that require low data rates, unexploited opportunities exist for increasing the reliability of PLC within governing regulatory rules. Reliable, low-bandwidth PLC facilitates new, inexpensive opportunities for demand-side management of the loads in a building or facility. This paper presents approaches for tailoring PLC for reliable low-bandwidth communication, and presents experimental demonstrations in a 24-floor high-rise building with challenging channel conditions.
Quality optimization of H.264/AVC video transmission over noisy environments using a sparse regression framework (2015)

We propose the use of the Least Absolute Shrinkage and Selection Operator (LASSO) regression method in order to predict the Cumulative Mean Squared Error (CMSE), incurred by the loss of individual slices in video transmission. We extract a number of quality-relevant features from the H.264/AVC video sequences, which are given as input to the LASSO. This method has the benefit of not only keeping a subset of the features that have the strongest effects towards video quality, but also produces accurate CMSE predictions. Particularly, we study the LASSO regression through two different architectures; the Global LASSO (G.LASSO) and Local LASSO (L.LASSO). In G.LASSO, a single regression model is trained for all slice types together, while in L.LASSO, motivated by the fact that the values for some features are closely dependent on the considered slice type, each slice type has its own regression model, in an e ort to improve LASSO's prediction capability. Based on the predicted CMSE values, we group the video slices into four priority classes. Additionally, we consider a video transmission scenario over a noisy channel, where Unequal Error Protection (UEP) is applied to all prioritized slices. The provided results demonstrate the efficiency of LASSO in estimating CMSE with high accuracy, using only a few features. les that typically contain high-entropy data, producing a footprint that is far less conspicuous than existing methods. The system uses a local web server to provide a le system, user interface and applications through an web architecture.
Resistance to tumor necrosis factor (TNF) cytotoxicity by autocrine TNF production is independent of intracellular signaling pathways (1997)

We previously showed that autocrine tumor necrosis factor (TNF) production in the TNF-sensitive L929sA fibrosarcoma cell line induced TNF resistance, which is correlated with downmodulation of both TNF receptors on the cell surface. We now analyzed whether autocrine TNF production also interfered with intracellular TNF signaling pathways. The L929sA-CAT-R55i cell line, in which cell death can be induced by controlled cytoplasmic expression of a trimeric fusion protein between chloramphenicol acetyltransferase and the intracellular domain of TNF-R55 (CAT-R55i), was supertransfected with the murine TNF gene. Expression of the latter conferred resistance to cell death induced by exogenous TNF, while cytotoxicity induced by CAT-R55i was not impaired. This demonstrates that autocrine TNF did not induce intracellular mechanisms that block TNF signaling leading to cell death. Thus the induction of TNF resistance via autocrine TNF production in L929sA cells is solely due to downmodulation of TNF receptors on the cell surface.
Maintained Efficacy of the Tyrosine Kinase Inhibitor Imatinib Mesylate in a Patient With Rheumatoid Arthritis (2008)

Eklund, Kari K. MD*; Lindstedt, Ken PhD†; Sandler, Charlotta PhD*; Kovanen, Petri T. MD†; Laasonen, Leena MD‡; Juurikivi, Annika PhD*; Wolff, Henrik MD§; Mykkänen, Marko MD¶; Joensuu, Heikki MD∥ Author Information
Selective catalytic reduction of NOx with propene over CeO2-ferrierite (2002)

CeO2-HFerrierite catalysts, prepared by physically mixing the components, showed very high conversions of NO under dry and wet conditions and excellent regeneration properties of the coked catalyst in the presence of water.
Optimisation thermique de moules d'injection construits par des processus génératifs (2002)

Une des potentialites les plus remarquables des procedes de production generatifs, comme le frittage selectif par laser, est leur capacite a fabriquer des moules pour l'injection plastique equipes directement de canaux de refroidissement conformes, parfaitement adaptes aux empreintes. Pour que l'industrie de l'injection puisse tirer pleinement parti de cette nouvelle opportunite, il est necessaire de mettre a la disposition des moulistes des logiciels de simulation capables d'evaluer les gains de productivite et de qualite realisables avec des systemes de refroidissement mieux adaptes. Ces logiciels devraient aussi etre capables, le cas echeant, de concevoir le systeme de refroidissement optimal dans des situations ou l'empreinte d'injection est complexe. Devant le manque d'outils disponibles dans ce domaine, le but de cet article est de proposer un modele simple de moules d'injection. Ce modele permet de comparer differentes strategies de refroidissement et peut etre couple avec un algorithme d'optimisation.
Mouse models of uterine corpus tumors clinical significance and utility (2010)

Uterine tumors, whether benign or malignant, are diagnosed in a significant portion of women and are associated with a number of co-morbidities that negatively impact quality of life. Uterine tumors can be derived from the epithelial (endometrial hyperplasia or carcinoma) and mesenchymal (leiomyoma, sarcoma) layers of the uterus. The exact etiologies of the various tumor types are yet to be defined. Collectively their development and progression often results from aberrant steroid hormone exposure or dysregulation of related growth factor signaling and apoptotic pathways, reflecting the role of steroid hormone-dependent signaling and survival pathways in the cycles of cell growth and involution that characterize normal uterine physiology. While molecular analyses of human tumors can identify candidate genetic and epigenetic lesions contributing to uterine tumor initiation and progression, in vivo genetic models are needed to establish the functional significance of such lesions and their contribution to tumorigenesis. For this purpose, genetically-engineered mouse models have proven valuable. Here we review genetically-modified mouse models that develop uterine tumors and compare their pathology, utility/feasibility, and discuss their clinical relevance.
Comparison of pulse wave velocity derived from accelerometer and reflective photo-plethysmography signals placed at the carotid and femoral artery (2016)

Carotid - femoral pulse wave velocity is an established measure to assess cardiovascular risk and an interesting surrogate parameter towards non-invasive continuous blood pressure inference. Due to progress in sensing technologies for wearable wrist worn sensors, there are low cost sensor combinations of photo-plethysmography and high fidelity accelerometers available offering access to pulse information from larger arteries complemented by blood volume changes in the superficial tissue. In this work we compare pulse wave velocities derived from accelerometer and reflective photo-plethysmography signals placed at the carotid and femoral artery. We discuss the different underlying physiological processes for the two sensing principles and present experimental results obtained in a study with healthy subjects.
Hardware architectures for Successive Cancellation Decoding of Polar Codes (2010)

The recently-discovered polar codes are widely seen as a major breakthrough in coding theory. These codes achieve the capacity of many important channels under successive cancellation decoding. Motivated by the rapid progress in the theory of polar codes, we propose a family of architectures for efficient hardware implementation of successive cancellation decoders. We show that such decoders can be implemented with O(n) processing elements and O(n) memory elements, while providing constant throughput. We also propose a technique for overlapping the decoding of several consecutive codewords, thereby achieving a significant speed-up factor. We furthermore show that successive cancellation decoding can be implemented in the logarithmic domain, thereby eliminating the multiplication and division operations and greatly reducing the complexity of each processing element.
Multi-organ impairment and Long COVID: a 1-year prospective, longitudinal cohort study (2022)

Abstract Importance Multi-organ impairment associated with Long COVID is a significant burden to individuals, populations and health systems, presenting challenges for diagnosis and care provision. Standardised assessment across multiple organs over time is lacking, particularly in non-hospitalised individuals. Objective To determine the prevalence of organ impairment in Long COVID patients at 6 and at 12 months after initial symptoms and to explore links to clinical presentation. Design This was a prospective, longitudinal study in individuals following recovery from acute COVID-19. We assessed symptoms, health status, and multi-organ tissue characterisation and function, using consensus definitions for single and multi-organ impairment. Physiological and biochemical investigations were performed at baseline on all individuals and those with organ impairment were reassessed, including multi-organ MRI, 6 months later. Setting Two non-acute settings (Oxford and London). Participants 536 individuals (mean 45 years, 73% female, 89% white, 32% healthcare workers, 13% acute COVID-19 hospitalisation) completed baseline assessment (median: 6 months post-COVID-19). 331 (62%) with organ impairment or incidental findings had follow up, with reduced symptom burden from baseline (median number of symptoms: 10 and 3, at 6 and 12 months). Exposure SARS-CoV-2 infection 6 months prior to first assessment. Main outcome Prevalence of single and multi-organ impairment at 6 and 12 months post-COVID-19. Results Extreme breathlessness (36% and 30%), cognitive dysfunction (50% and 38%) and poor health-related quality of life (EQ-5D-5L&lt;0.7; 55% and 45%) were common at 6 and 12 months, and associated with female gender, younger age and single organ impairment. At baseline, there was fibro-inflammation in the heart (9%), pancreas (9%), kidney (15%) and liver (11%); increased volume in liver (7%), spleen (8%) and kidney (9%); decreased capacity in lungs (2%); and excessive fat deposition in the liver (25%) and pancreas (15%). Single and multi-organ impairment were present in 59% and 23% at baseline, persisting in 59% and 27% at follow-up. Conclusion and Relevance Organ impairment was present in 59% of individuals at 6 months post-COVID-19, persisting in 59% of those followed up at 1 year, with implications for symptoms, quality of life and longer-term health, signalling need for prevention and integrated care of Long COVID. Trial Registration ClinicalTrials.gov Identifier: NCT04369807 Key points Question: What is the prevalence of organ impairment in Long COVID at 6- and 12-months post-COVID-19? Findings: In a prospective study of 536 mainly non-hospitalised individuals, symptom burden decreased, but single organ impairment persisted in 59% at 12 months post-COVID-19. Meaning: Organ impairment in Long COVID has implications for symptoms, quality of life and longer-term health, signalling need for prevention and integrated care of Long COVID.
Sum-Rate Capacity Investigation of Multiuser Massive MIMO Uplink Systems in Semi-Correlated Channels (2016)

The recent hot research topic of a massive multiple-output (MIMO) has been primarily studied based on the assumption that channel vectors are asymptotically pairwise orthogonal. This condition is not exactly satisfied in practice. Correlation will occur among antenna elements at the base- station antenna array in a dense scattering environment, or in a LOS propagation condition. In this paper, by using the Mellin transform of the eigenvalue distribution, we derive the semi- correlated sum-rate capacity of multi-antenna channels with an arbitrary number of antennas in closed form. Afterwards, we employ two commonly- used correlation models to compare the theoretical closed-form results and the simulated results and the final results show that they match well.