gebhart/patrepeval huggingface dataset:
Nuclear magnetic resonance studies of intracellular ions in perfused frog heart (1987)

Intracellular sodium, potassium, and lithium were observed in a perfused frog heart by nuclear magnetic resonance (NMR) spectroscopy. A perfusate buffer containing the shift reagent, dysprosium tripolyphosphate, was used in combination with mathematical filtering or presaturation of the extracellular resonance to separate the intra- and extracellular sodium NMR signals. Addition of 10 microM ouabain to the perfusate, perfusion with a zero potassium, low-calcium buffer, and replacement of 66% of the perfusate sodium with lithium resulted in the following percent changes in the intracellular sodium levels (mean +/- SD): ouabain + 460 +/- 60% (n = 6), zero potassium + 300 +/- 30% (n = 3), and lithium - 51 +/- 6% (n = 3). An increase of 45% in the intracellular sodium was observed when changing the pacing rate from 0 to 60 beats/min (with proportional changes for intermediate pacing rates). The ratio of intracellular potassium to sodium concentration was determined to be 2.3 by NMR, indicating that a substantial amount of the intracellular potassium is undetectable with these NMR methods. In addition, intracellular lithium was observed during perfusion with a lithium-containing perfusate.
Fermentation of Dietary Fibre by Human Colonic Bacteria: Disappearance of, Short-Chain Fatty Acid Production from, and Potential Water-Holding Capacity of, Various Substrates (1993)

Several dietary fibre-rich substrates were fermented in vitro with human colonic bacteria obtained from each of three adult male subjects to assess the extent of substrate fermentation short-chain fatty acid (SCFA) production, and the potential effect of fermented residues on faecal bulk. Substrates tested were two varieties of oat hull fibre, gum arabic, carboxymethylcellulose (CMC), soy fibre, psyllium, and six blends containing oat fibre, gum arabic, and CMC in various proportions. All substrates contained greater than 900 g/kg of total dietary fibre except for CMC (816 g) and soy fibre (778 g). In vitro organic matter disappearance during fermentation was greatest for gum arabic (69.5%), intermediate for soy fibre (56.4%), and less than 20% for the two oat fibres, CMC, and psyllium. Averaged across substrates, acetate, propionate, and butyrate were produced in the molar proportion of 64:24:12. Potential water-holding capacity (PWHC) of substrates, a measure of faecal bulking potential, was greatest for CMC (13.5 g H2O/g substrate) and lowest for gum arabic (1.92 g) and soy fibre (1.71 g). Organic matter disappearance and SCFA production of blends were directly proportional to their gum arabic content. Blend PWHC was proportional to CMC content. In vitro procedures are useful in predicting the actions of fibre blends formulated to produce desirable effects in vivo.
Comparison of DSP Equalizer Complexity between Strongly and Weakly Coupled Few Mode Fiber Transmission Systems (2013)

We analyze the complexity of MIMO-equalizers in both strongly and weakly-coupled FMF transmission systems. We found that the blind equalizer in the latter system has significantly smaller complexity than that in the former system.
Virtual Bronchoscopy Planner and Radial-EBUS Guided Biopsy for Organizing Pneumonia Diagnosis (2021)

r-EBUS, when performed shortly after a CT scan showing a bronchus sign, is an efficient and safe technique for OP diagnosis.
Pharmacokinetics of the Anti-Human Immunodeficiency Virus Agent 1-(β-d-Dioxolane)Thymine in Rhesus Monkeys (2007)

Beta-D-dioxolane-thymine (D-DOT) has potent and selective in vitro activity against several clinically important resistant human immunodeficiency virus (HIV) mutants and is in advanced preclinical development. Therefore, the single-dose intravenous and oral pharmacokinetics of D-DOT were studied with three rhesus monkeys. The pharmacokinetic profiles of D-DOT in serum and urine were adequately described by a two-compartment open pharmacokinetic model. D-DOT was rapidly and almost completely absorbed (absorption rate constant = 2.7 h(-1); fraction of oral dose absorbed = 0.82 to 1.06). The average serum beta half-life was 2.16 h. The average central and steady-state volumes of distributions were 0.52 and 1.02 liter/kg of body weight, respectively, and the average systemic and renal clearance values were 0.36 liter/h/kg and 0.18 liter/h/kg. Four or eight percent of administered D-DOT was eliminated in the urine as glucuronide within 8 h after intravenous or oral administration, respectively. D-DOT reached levels in the cerebrospinal fluid in excess of 10 to 20 times the median effective concentration for wild-type HIV and resistant mutants. The potent antiretroviral activity of D-DOT against a lamivudine- and zidovudine-resistant HIV-1 mutant, together with an excellent pharmacokinetic profile for rhesus monkeys, suggest that further development is warranted.
Regulation of cardiac mitochondrial monolysocardiolipin acyltransferase activity and expression during development and in fetal alcohol syndrome. (2007)

Fetal alcohol syndrome is a serious developmental disorder and exposure of the fetal heart to alcohol results in disturbances in the biochemistry of all cellular substructures. Mitochondrial effects include diminished respiratory function and physical alteration of the membrane secondary to interaction of ethanol with the hydrophobic region of the bilayer. Cardiolipin is a major mitochondrial membrane phospholipid in the heart and plays an important role in the function of mitochondrial enzymes involved in cellular respiration. We examined the activity of cardiac monolysocardiolipin acyltransferase, a key enzyme responsible for the molecular remodelling of cardiolipin with new fatty acids, in the newborn and adult rat and in new born rats that were exposed to alcohol in utero. Cardiac monolysocardiolipin acyltransferase activities were 57% lower (p < 0.05) in adult rats compared to newborn rats. Cardiac mitochondrial monolysocardiolipin acyltransferase activities were 36% lower (p < 0.05) in newborn rats that were exposed to alcohol in utero and this was due to reduced mitochondrial monolysocardiolipin acyltransferase expression. The results indicate that cardiac mitochondrial monolysocardiolipin acyltransferase activity declines during postnatal development in the rat and that in utero exposure to alcohol inhibits cardiac monolysocardiolipin acyltransferase activity and expression.
2100 W at 425 MHz with SiC RF power BJTs (2005)

4H-SiC RF bipolar junction transistors (BJTs) have been designed and tested at 425 MHz. Twenty four cells representing approximately 24 inches of emitter periphery were packaged and tested at 425 MHz in common emitter, Class C mode with a 75 V power supply voltage. The pulse width was 2 μs and duty cycle 1%. The total output power was measured to be 2100 W with a power gain of 6.3 dB, collector efficiency of 45% and power added efficiency of 35%. This is the first time, SiC BJTs have been used to produce an output power in excess of 2 kW at 425 MHz. Although the gain and PAE are not very high, the individual cells are capable of producing 50 W with a gain of 9.3 dB and 51% collector efficiency (Agarwal, 2002). By further optimization of the device design, cell layout, the input and output match, and by increasing the power supply voltage to 120 V, it is expected that the output power, gain and efficiency can be further improved
Antimicrobial prophylaxis in adults and children undergoing hematopoietic cell transplantation: 2021 Polish recommendations (2021)

Infections are still a major reason of morbidity and one of the most common causes of death after hematopoietic cell transplantation (HCT). Antimicrobial prophylaxis plays a crucial role in decreasing non-relapse mortality after HCT. The objective of this guideline paper is presentation of current recommendations of antimicrobial prophylaxis for children and adults after hematopoietic cell transplantation, prepared in cooperation of Polish scientific hematological societies. Recommendations were prepared by the working group and finally approved by all 23 Polish transplant centers for children and adults. Existing ECIL (European Conference on Infections in Leukemia) and EBMT (European Society of Blood and Marrow Transplantation) guidelines, as well as results of survey performed among all Polish transplant centers, were the background material for working group. Recommendations are presented in sections dedicated to antibacterial prophylaxis, antifungal prophylaxis, antiviral prophylaxis, as well as prophylaxis of toxoplasmosis and infections with Pneumocystis jiroveci. Recommendations on principles of vaccination against COVID-19 are provided based on the state of knowledge in September 2021. A section on guidelines of environmental prophylaxis is also presented.
The First Total Synthesis of Tanzawaic Acid B (2023)

The first total synthesis of (+)-tanzawaic acid B, a natural polyketide bearing a pentadienoic ester and octalin moiety, has been accomplished. The synthetic improvement from previous synthetic conditions facilitated our gram-scale synthesis of the chiral octalin that possesses seven stereogenic centers and that is the core skeleton of almost all of the tanzawaic acid family.
Multiple hydride reduction pathways in isoflavonoids (2006)

The work described in this paper shows that most structural types of reduced isoflavonoids are now reliably available in satisfactory or good yields by hydride reductions to be used as authentic reference compounds in analytical and biological studies.
CArG box‐binding factor‐A interacts with multiple motifs in immunoglobulin promoters and has a regulated subcellular distribution (2006)

CArG box-binding factor-A (CBF-A) is a protein involved in transcriptional control and interacts specifically with the penta-decameric (pd) element in kappa promoters. We show here that CBF-A will also bind specifically to a second region in the kappa promoter that overlaps with an early B cell factor binding site. Furthermore, the same region is present in multiple Ig promoters and we show that CBF-A can bind to several of these. Mitogenic stimulation of untransformed B lymphocytes promoted nuclear localisation of CBF-A. Using enhanced GFP (EGFP)-tagged constructs and transfection into COS7 cells, a nuclear localisation signal was defined in the C terminus of CBF-A. Deletion of only 13 amino acids from the C terminus of CBF-A led to the accumulation of the protein in bright speckles at the nuclear/cytoplasmic border. We also identified the heterogeneous ribonucleoprotein H as a specific interaction partner of CBF-A, but this interaction could be detected in the cytoplasm only. Thus, CBF-A has the potential to regulate the expression of multiple Ig V genes and has a complex, mitogen-responsive regulation of its intracellular localisation.
Arabidopsis translation initiation factor binding protein CBE1 negatively regulates accumulation of the NADPH oxidase respiratory burst oxidase homolog D (2023)

Cell surface pattern recognition receptors sense invading pathogens by binding microbial or endogenous elicitors to activate plant immunity. These responses are under tight control to avoid excessive or untimely activation of cellular responses, which may otherwise be detrimental to host cells. How this fine-tuning is accomplished is an area of active study. We previously described a suppressor screen that identified Arabidopsis thaliana mutants with regained immune signaling in the immunodeficient genetic background bak1-5, which we named modifier of bak1-5 (mob) mutants. Here, we report that bak1-5 mob7 mutant restores elicitor-induced signaling. Using a combination of map-based cloning and whole-genome resequencing, we identified MOB7 as conserved binding of eIF4E1 (CBE1), a plant-specific protein that interacts with the highly conserved eukaryotic translation initiation factor eIF4E1. Our data demonstrate that CBE1 regulates the accumulation of respiratory burst oxidase homolog D, the NADPH oxidase responsible for elicitor-induced apoplastic reactive oxygen species production. Furthermore, several mRNA decapping and translation initiation factors colocalize with CBE1 and similarly regulate immune signaling. This study thus identifies a novel regulator of immune signaling and provides new insights into reactive oxygen species regulation, potentially through translational control, during plant stress responses.
Self-Healing Ring-Based Time-Sharing Passive Optical Networks (2007)

A new ring-based time-shared passive optical network (PON), with a self-healing function to prevent the occurrence of fiber-fault, has been proposed and investigated experimentally. By using the new optical line termination and single fiber path architecture, the proposed self-healing ring topology PON can be revived promptly under single fiber failure. The system performances of the proposed access network are also measured and discussed.
Statistical Analysis of the Fatigue Life Distribution of Monolithic Silicon Nitride (1994)

Cyclic fatigue testing of silicon nitride ceramics was performed at a frequency of f = 150 Hz and a stress ratio of R = 0.1 using a piezoelectric bimorph fatigue device. Based on the method proposed by Fett and Munz, a fatigue crack growth diagram ( K 1 – V diagram) was estimated from fatigue lifetime distribution data. A change in the slope of the K I – V diagram was observed. A statistical analysis for predicting the lifetime of ceramics exhibiting a transition in a K I – V diagram was devised on the basis of this observation. Analytical results obtained with this method showed good agreement with experimental data.
Relations between physical parameters and kinetics of photo‐induced radical polymerization in polymer binders: Radical polymerization of acrylamide (1992)

Abstract The photo‐induced radical polymerization of acrylamide has been investigated in combinations of two polymers containing carboxy groups. The kinetic parameters of this polymerization, measured with a calorimetric method, depend on the proportion of the two polymers in the system. In mixtures with the lowest glass transition temperature, the polymerization rates are the highest. These transition temperatures have been determined with a special fluorescene technique using crystal violet as probe. Presumably, the effects measured in the systems are based on the strong polar interactions between the carboxy groups of both polymers.
Lumbar total disc replacement from an extreme lateral approach: clinical experience with a minimum of 2 years' follow-up (2010)

long-term results of a laterally placed TDR device demonstrate maintenance of pain relief and functional improvement. The benefits of this technique-minimal morbidity, avoiding mobilization of the great vessels, preserving the ALL, biomechanically stable orientation, and broader revision options-suggest a promising new direction for TDR procedures.
Transcriptomics in pain research: insights from new and old technologies (2018)

Despite significant advances in our understanding of the molecular basis of pain, the precise contributions of individual genes to our perception of this primal sensation remains incomplete. However, transcriptomic studies - providing a snapshot of the mRNA expression of a given cell or tissue - have considerably increased insight into the gene expression fingerprint of specific sensory neuronal subtypes, as well as gene expression changes that occur in diverse pathologies associated with pain. Moreover, transcriptomic studies have accelerated the identification of venom-derived peptides that may provide novel leads for the development of analgesics. This review discusses some of the key techniques, insights and limitations of transcriptomic studies that have contributed to pain research and highlights how the application of transcriptomics can be used to accelerate analgesic venom peptide drug discovery.
Long-term remission in diffuse histiocytic lymphoma treated with combination sequential chemotherapy (1975)

Seventeen patients with Stage III or IV reticulum cell sarcoma were treated with three cycles of a 5-drug regimen between February, 1969 and December, 1970. Of the 17 patients, 9 attained a complete remission and 6 had a partial remission; 2 were considered unevaluable. Recently, the original biopsies from these patients were reclassified according to the criteria of Rappaport et al.7 The results were: diffuse histiocytic—8; nodular histiocytic—2; diffuse mixed—2; nodular mixed—3; diffuse lymphocytic poorly differentiated—1; nodular lymphocytic poorly differentiated—1. Of the 8 patients with diffuse histiocytic lymphoma 6 attained complete remission, 1 had a partial remission, and 1 was unevaluable. One of the 6 with complete remission relapsed at 7 months and died 2 months later. However, the other 5 are alive and in continued unmaintained remission for 55 to 65 months.
Quasi-static methods to evaluate seat strength in rear impacts (2022)

Results from different tests cannot be readily compared because of different loading conditions, including body shape and height of load about the H-point, which can cause the seat structure to respond differently.
Promising survival and disease control in third-line or greater metastatic or locally advanced pancreatic cancer patients following chemo-radiation and novel combination of aldoxorubicin, N-803 IL-15 superagonist, and PDL1- NK cell therapy. (2022)

582 Background: Pancreatic cancer claimed an estimated 47,050 lives in the USA in 2020, with an expected median overall survival (OS) of 3 months in 3rd line. (Manax ASCO GI 2019), with no evidence of disease control in these late stage patients. We hypothesize that effective response against pancreatic cancer requires orchestration of both the innate and adaptive immune system to accomplish immunogenic cell death with survival benefit. Herein we report the first results of a novel combination immunotherapy protocol of low-dose chemoradiation, cytokine-induced NK and T cell activation via N-803 (an IL-15 cytokine superagonist), and allogeneic off-the-shelf PDL1-targeted high-affinity NK cell (PDL1 t-haNK) infusion. Methods: We report data from a multi-center study, on 55 3rd line or greater, subjects treated with low dose, chemo radiation Nab-paclitaxel (100 mg/ m2 IV), Gemcitabine (600 mg/m2 IV); Cyclophosphamide (50 mg PO BID) and low dose SBRT. This induction immuno-modulation therapy to induce DAMPs was followed with investigational agents activating the innate and adaptive systems: Aldoxorubicin (150 mg/m2 IV), N-803, an IL-15 superagonist (15 μg/kg SC) and PD-L1 t-haNK (̃2 × 109cells/dose IV). Prophylactic G-CSF or EPO was not allowed. All treatments were administered on an outpatient basis. Results: As of submission, median follow-up is 3.9 months. Median age 62, M:F ratio 35:20. ECOG 0-1,92%. 41/55 (75%) subjects reported a grade ≥3 AE related to the chemo radiation, anemia 44%, neutropenia 24%, thrombocytopenia 11%, all others &lt; 10%. SAEs attributed to investigational agents were reported in 5/55 (9%) patients. Of the 44 patients evaluable at 3 months to date, the OS is 81.8% (36/44), 95% CI: 67.3%, 91.8%. The disease control rate of 47 evaluable patients is 36.2% (17/47) 95% CI 22.7%,51.5%. No treatment related deaths have occurred. Treatment is ongoing for 16 subjects, with 14 months as the longest duration on therapy to date. Median OS not yet reached with 28/55 alive to date. Median PFS is 2.4 months (95% CI: 2.0, 3.7) and 36% of subjects not having progressed to date. Conclusions: Historical 3 month median OS in 3rd line metastatic pancreatic cancer patients has been exceeded. Early safety and promising efficacy is seen in QUILT 88 investigating a novel combination immunotherapy protocol of low-dose chemoradiation, N-803 and PDL1 t-haNK therapy. Updated data will be presented. Clinical trial information: NCT04390399.
Performance assessment of a new calibration method used for clock synchronization on impulse radio based Ultra-Wideband receivers (2010)

Part 1:Ongoing work âPositioning systems âBasics of UWB âWhy UWB âWhere UWB stands âChallenge: Synchronization of receivers âCRLB derivation Part 2:Outlook âCooperative localization : an example.
Wear Induced Sub-surface Deformation Characteristics of a 26 Wt% Cr White Cast Iron Subjected to a Destabilization Heat Treatment (2022)

Abstract In the present work, the sub-surface microstructure of a heat treated and worn 26 wt% Cr white cast iron was investigated to gain better insight into the tribological behaviour of the material. The samples were destabilized at 980 °C for 0 (Q_0), 30 (Q_30) and 90 (Q_90) minutes followed by air cooling, and later subjected to dry-sliding linear reciprocating wear tests. The microstructural characterization of the area under the wear track was carried out using a combination of SEM, EDS and EBSD. Additionally, nanoindentation (NI) measurements were used to corroborate the mechanical behaviour with the microstructural observations. EBSD and NI measurements indicated that the matrix area underneath the wear track in Q_0 had undergone significant plastic deformation resulting in a drastic increase in hardness, whereas no such phenomena was observed in the Q_90. This was attributable to the relatively high amount of retained austenite in the former and a predominately martensitic matrix in the latter. Moreover, the large M 7 C 3 eutectic carbides were less cracked in the destabilized samples compared to the as-cast sample owing to the presence of martensite and dispersed secondary carbides, leading to an increased matrix load-bearing capacity. These factors led to the destabilized samples showing a lower wear rate compared to the as-cast sample, and the Q_0 showing the best wear resistance amongst all the samples.
Intrachain rotations in the poly(ester carbonates). 2. Quantum-mechanical calculations on large model molecules fully representing each type of phenyl ring environment (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntrachain rotations in the poly(ester carbonates). 2. Quantum-mechanical calculations on large model molecules fully representing each type of phenyl ring environmentJozef Bicerano and Hayden A. ClarkCite this: Macromolecules 1988, 21, 3, 597–603Publication Date (Print):March 1, 1988Publication History Published online1 May 2002Published inissue 1 March 1988https://pubs.acs.org/doi/10.1021/ma00181a009https://doi.org/10.1021/ma00181a009research-articleACS PublicationsRequest reuse permissionsArticle Views54Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts