gebhart/patrepeval huggingface dataset:
Proceedings of the 15th international conference on World Wide Web (2006)

On behalf of the entire organizing committee, we welcome you to Edinburgh and WWW2006. This is the 15th conference in a series that was started in Geneva in 1994 and has subsequently been held in locations all over the world. WWW2006 is the first conference in the series to be held in the United Kingdom. This year's conference has made a number of structural innovations over previous conferences including integrating both the developer track and tutorials with the main conference program instead of holding them on separate days. There are two days of workshops compared with one day at previous conferences. The rich content provided over the five days of the conference include the latest research laying the groundwork for the future of the Web, the latest technology for Web developers, and presentations and discussions on how the Web is affecting industry, education, government, and society in general.The conference includes a wide variety of technical presentations, panel discussions, tutorials, and keynote addresses. We have many very distinguished speakers including Professor Sir Tim Berners-Lee, inventor of the Web, and the event is opened by Jack McConnell (First Minister of Scotland).
Meeting report: SMART timing—principles of single molecule techniques course at the University of Michigan 2014 (2014)

Four days after the announcement of the 2014 Nobel Prize in Chemistry for "the development of super-resolved fluorescence microscopy" based on single molecule detection, the Single Molecule Analysis in Real-Time (SMART) Center at the University of Michigan hosted a "Principles of Single Molecule Techniques 2014" course. Through a combination of plenary lectures and an Open House at the SMART Center, the course took a snapshot of a technology with an especially broad and rapidly expanding range of applications in the biomedical and materials sciences. Highlighting the continued rapid emergence of technical and scientific advances, the course underscored just how brightly the future of the single molecule field shines.
Sidelobe Level and Aperture Efficiency Optimization for Tiled Aperiodic Array Antennas (2017)

Array antennas with aperiodic element placement provide a way to mitigate grating lobe level when the array element spacing is larger than one half wavelength. Design techniques for aperiodic arrays include thinning, numerical optimization, and other methods, but even with modern tools, designing electrically large aperiodic arrays remain computationally challenging. To reduce the complexity of the large aperiodic array design problem, we study the use of discrete rotated tiles with element positions and tile orientations optimized to minimize peak sidelobe level (PSLL). The directivity, frequency sensitivity of PSLL, and optimization complexity for uniform arrays, aperiodic arrays, and tiled arrays are compared. Based on many numerical examples, an approximate relationship between PSLL and array element number and density for aperiodic and tiled arrays is proposed as a convergence estimator for the design optimization process.
Fibre Length Reduction in Natural Fibre-Reinforced Polymers during Compounding and Injection Moulding—Experiments Versus Numerical Prediction of Fibre Breakage (2018)

To establish injection-moulded, natural fibre-reinforced polymers in the automotive industry, numerical simulations are important. To include the breakage behaviour of natural fibres in simulations, a profound understanding is necessary. In this study, the length and width reduction of flax and sisal fibre bundles were analysed experimentally during compounding and injection moulding. Further an optical analysis of the fibre breakage behaviour was performed via scanning electron microscopy and during fibre tensile testing with an ultra-high-speed camera. The fibre breakage of flax and sisal during injection moulding was modelled using a micromechanical model. The experimental and simulative results consistently show that during injection moulding the fibre length is not reduced further; the fibre length was already significantly reduced during compounding. For the mechanical properties of a fibre-reinforced composite it is important to overachieve the critical fibre length in the injection moulded component. The micromechanical model could be used to predict the necessary fibre length in the granules.
Co-infections of Adenovirus Species in Previously Vaccinated Patients (2006)

Despite the success of the adenovirus vaccine administered to US military trainees, acute respiratory disease (ARD) surveillance still detected breakthrough infections (respiratory illnesses associated with the adenovirus serotypes specifically targeted by the vaccine). To explore the role of adenoviral co-infection (simultaneous infection by multiple pathogenic adenovirus species) in breakthrough disease, we examined specimens from patients with ARD by using 3 methods to detect multiple adenoviral species: a DNA microarray, a polymerase chain reaction (PCR)-enzyme-linked immunosorbent assay, and a multiplex PCR assay. Analysis of 52 samples (21 vaccinated, 31 unvaccinated) collected from 1996 to 2000 showed that all vaccinated samples had co-infections. Most of these co-infections were community-acquired serotypes of species B1 and E. Unvaccinated samples primarily contained only 1 species (species E) associated with adult respiratory illness. This study highlights the rarely reported phenomenon of adenoviral co-infections in a clinically relevant environment suitable for the generation of new recombinational variants.
1-nm linewidth room temperature single-photon source from optical microcavity-embedded CsPbI3 perovskite quantum dots (2022)

Abstract Ultra-narrow bandwidth single-photon sources operating at room temperature are of vital importance for viable optical quantum technologies at scale, including quantum key distribution, cloud-based quantum information processing networks, and quantum metrology. Here we show a room-temperature single-photon source generating polarised photons at a rate of 5MHz based on an inorganic CsPbI3 perovskite quantum dot embedded in a tunable open optical microcavity. When coupled to the mode of the optical cavity, the quantum dot room-temperature emission becomes single-mode and the spectrum narrows down to just ∼ 1 nm. The excellent directionality of the optical modes enables high single-mode collection at RT, offering promising performance for photonic and quantum technology applications. We measure 94% single-photon purity under pulsed and continuous-wave (CW) excitation.
A human glial hybrid cell line differentially expressing genes subserving oligodendrocyte and astrocyte phenotype (1995)

We have developed a series of immortal human-human hybrid cell lines that express phenotypic characteristics of primary oligodendrocytes, by fusing a 6-thioguanine-resistant mutant of the human rhabdomyosarcoma RD with adult human oligodendrocytes by a lectin-enhanced polyethylene glycol procedure. Hybrids were selected in an aminopterin-containing media. In contrast to the tumor parent cells, a hybrid clone M03.13 expressed surface immunoreactivity for galactosyl cerebroside and intracellular immunoreactivity for myelin basic protein (MBP), proteolipid protein (PLP), and glial fibrillary acidic protein (GFAP). Serum deprivation or chronic treatment with a protein kinase C activator 4-beta-phorbol 12-myristate 13-acetate (PMA), but not dibutyl cyclic adenosine monophosphate induced coordinate up-regulation or de novo induction of oligodendrocyte phenotypic markers with concomitant down-regulation of GFAP expression. Consistent with immunohistochemical studies, northern blot analysis demonstrated that both MBP and PLP mRNA were up-regulated in MO3.13 cells by PMA treatment. M03.13 cells provide an immortalized clonal model system suitable for study of gene expression subserving oligodendrocyte and astrocyte phenotypes.
Intermodal Bragg-Scattering Four Wave Mixing in Silicon Waveguides (2019)

We demonstrate optical wavelength conversion in a multi-mode silicon waveguide using four wave mixing Bragg scattering enabled by a dual-pump CW scheme. The original signal and the generated idler pair excite one spatial mode (first, TE mode), while the two pumps excite a different spatial mode (second, TE mode) of the same waveguide. Our approach exploits the differences in the group velocities of the various supported spatial modes to ensure phase matching only for the desired nonlinear process. In this proof-of-principle experiment, any unintended idlers are generated with an extinction ratio up to 12 dB relative to the phase-matched idlers for a pumps-to-signal-idler-pair wavelength detuning of about 70 nm. The scalability of the scheme to achieve larger and multiple signal wavelength detunings from the pump frequencies is also discussed.
Complex Electrical Measurements on an Undisturbed Soil Core: Evidence for Improved Estimation of Saturation Degree from Imaginary Conductivity (2013)

Recent studies have shown that induced polarization (IP) coupled with electrical resistivity surveys can be used for in situ lithological and hydrologic discrimination of the subsurface; yet the driving factors behind the effects of water content dynamics on IP are relatively understudied. We sought to improve the understanding of the relationship of IP on variations in water saturation degree for an undisturbed agricultural soil. Our experiment consisted of collecting IP measurements concurrently with hydraulic data during multistep outflow experiments. We determined the hydraulic properties of the undisturbed soil samples and correlated saturation degree with IP data. Due to an increase in pore fluid conductivity in the column pore water with decreasing saturation degree, we found that imaginary conductivity (σ″) may offer distinct advantages for determining water content over real conductivity (σ′) measurements. Although σ″ exhibits a weaker dependence on saturation degree compared to σ′, the relative insensitivity of σ″ to pore fluid conductivity results in a simpler dependence on saturation change in the presence of varying salinities. As changes in pore fluid conductivity are likely to occur in the field simultaneously with water content variations, we suggest that although IP has mostly been used to discriminate lithology, time lapse IP measurements may additionally provide a robust indicator of changes in saturation degree.
Improvement of the thermal properties of optically pumped semiconductor chips at 850 nm (orale) (2014)

Thermal saturation of VECSELs emission properties stays a major issue in those applications, requiring a high precision on the chip emission wavelength (such as atomic clocks experiments). In this paper we analyze the possibility to reduce the thermal resistance of the semiconductor chip emitting at 850nm by means of substrate substitution method. We propose two different techniques and compare their efficiency through experimental study on VECSEL emission properties.
Hardware-Friendly Intra Region-Based Template Matching for VVC (2019)

In a template matching (TM) intra method, the neighboring samples of the current block are regarded as a template. The decoder searches for the best template match in the current reconstructed picture using an error minimizing metric like sum of squared differences (SSD). The prediction signal is generated by copying the samples of the adjacent block to the selected template match. The increased decoder complexity from the search algorithm makes it less attractive for modern applications like video calling. In a previous publication [1], we presented a region-based template matching (RTM) approach for intra coding. Compared to the conventional TM methods which searches for the template match in a complete search window, RTM searches in a region of the search window. Thus, RTM offers a better trade-off between coding efficiency and decoder complexity. Nevertheless, the memory requirements and number of computations to be carried at the decoder are still high, making RTM difficult for hardware realization. This paper aims to address these issues.
Implementation of energy efficient single flux quantum digital circuits with sub-aJ/bit operation (2012)

We report the first experimental demonstration of recently proposed energy-efficient single flux quantum logic, eSFQ. This logic can represent the next generation of RSFQ logic eliminating dominant static power dissipation associated with a dc bias current distribution and providing over two orders of magnitude efficiency improvement over conventional RSFQ logic. We further demonstrate that the introduction of passive phase shifters allows the reduction of dynamic power dissipation by about 20%, reaching ~0.8 aJ per bit operation. Two types of demonstration eSFQ circuits, shift registers and demultiplexers (deserializers), were implemented using the standard HYPRES 4.5 kA/cm2 fabrication process. In this paper, we present eSFQ circuit design and demonstrate the viability and performance metrics of eSFQ circuits through simulations and experimental testing.
ChemInform Abstract: Fluorinated NAD as an Affinity Surfactant. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
X‐ray structures of Sap1 and Sap5: Structural comparison of the secreted aspartic proteinases from Candida albicans (2008)

Proteolytic activity is an important virulence factor for Candida albicans (C. albicans). It is attributed to the family of the secreted aspartic proteinases (Saps) from C. albicans with a minimum of 10 members. Saps show controlled expression and regulation for the individual stages of the infection process. Distinct isoenzymes can be responsible for adherence and tissue damage of local infections, while others cause systemic diseases. Earlier, only the structures of Sap2 and Sap3 were known. In our research, we have now succeeded in solving the X-ray crystal structures of the apoenzyme of Sap1 and Sap5 in complex with pepstatin A at 2.05 and 2.5 A resolution, respectively. With the structure of Sap1, we have completed the set of structures of isoenzyme subgroup Sap1-3. Of subgroup Sap4-6, the structure of the enzyme Sap5 is the first structure that has been described up to now. This facilitates comparison of structural details as well as inhibitor binding modes among the different subgroup members. Structural analysis reveals a highly conserved overall secondary structure of Sap1-3 and Sap5. However, Sap5 clearly differs from Sap1-3 by its electrostatic overall charge as well as through structural conformation of its entrance to the active site cleft. Design of inhibitors specific for Sap5 should concentrate on the S4 and S3 pockets, which significantly differ from Sap1-3 in size and electrostatic charge. Both Sap1 and Sap5 seem to play a major part in superficial Candida infections. Determination of the isoenzymes' structures can contribute to the development of new Sap-specific inhibitors for the treatment of superficial infections with a structure-based drug design program.
Prolonged evolution of the human B cell response to SARS-CoV-2 infection (2021)

A comprehensive understanding of the kinetics and evolution of the human B cell response to SARS-CoV-2 infection will facilitate the development of next-generation vaccines and therapies. Here, we longitudinally profiled this response in mild and severe COVID-19 patients over a period of five months. Serum neutralizing antibody (nAb) responses waned rapidly but spike (S)-specific IgG<sup>+</sup> memory B cells (MBCs) remained stable or increased over time. Analysis of 1,213 monoclonal antibodies (mAbs) isolated from S-specific MBCs revealed a primarily de novo response that displayed increased somatic hypermutation, binding affinity, and neutralization potency over time, providing evidence for prolonged antibody affinity maturation. B cell immunodominance hierarchies were similar across donor repertoires and remained relatively stable as the immune response progressed. Cross-reactive B cell populations, likely re-called from prior endemic beta-coronavirus exposures, comprised a small but stable fraction of the repertoires and did not contribute to the neutralizing response. The neutralizing antibody response was dominated by public clonotypes that displayed significantly reduced activity against SARS-CoV-2 variants emerging in Brazil and South Africa that harbor mutations at positions 501, 484 and 417 in the S protein. Overall, the results provide insight into the dynamics, durability, and functional properties of the human B cell response to SARS-CoV-2 infection and have implications for the design of immunogens that preferentially stimulate protective B cell responses.
Large-Curvature Deployable Developable Structures via Lamina Emergent Arrays (2015)

A method is presented utilizing networks of lamina emergent joints, known as lamina emergent arrays, to accommodate large-curvature developable structures that are also deployable. By exploiting the ruling lines in developable surfaces, this method enables developable structures that can be manufactured with two-dimensional geometry and yet have a greater range of elastic motion than is possible with a solid sheet of material. A mathematical model is developed to describe the resulting stiffness of the structure employing the lamina emergent arrays and equations are derived to facilitate stress analysis of the structure. Finite element results show the sensitivity of alignment of the elements in the array to the stress present in the developed structure. A specific technique for creating an array pattern for conical developable surfaces is described. Examples of developable structures, including curved-fold origami models transitioned to thick materials, are also examined.
Effect of Human Coronavirus OC43 Structural and Accessory Proteins on the Transcriptional Activation of Antiviral Response Elements (2018)

Both structural and accessory HCoV-OC43 proteins are able to inhibit antiviral response elements in HEK-293 cells, and to block the activation of different antiviral signaling pathways.
Generalized phase diversity for wave-front sensing (2004)

Phase diversity is a phase-retrieval algorithm that uses a pair of intensity images taken symmetrically about the wave front to be determined. If these images are taken about the system input pupil this is equivalent to a curvature-sensing algorithm. Traditionally a defocus aberration kernel is used to produce the phase-diverse data. We present a generalization of this method to allow the use of other functions as the diversity kernel. We discuss the necessary and sufficient conditions that such a function must satisfy for use in a null wave-front sensor. Computer simulations were used to validate these results.
Organic Photovoltaics: Singlet Fission of Non‐polycyclic Aromatic Molecules in Organic Photovoltaics (Adv. Mater. 8/2016) (2016)

On page 1585, Y.-J. Pu, J. Kido, and co-workers demonstrate the singlet fission of thienoquinoid compounds by measuring the magnetic-field dependence of the photocurrent of photovoltaic devices. Three kinds of thienoquinoid core and fluorene end-groups are chosen to satisfy the material conditions for singlet fission and organic photovoltaics at the same time. These materials aid in expansion of the molecular design of singlet fission materials.
Radical translocation reactions of o-iodoanilides: the use of carbon-hydrogen bonds as precursors of radicals adjacent to carbonyl groups (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRadical translocation reactions of o-iodoanilides: the use of carbon-hydrogen bonds as precursors of radicals adjacent to carbonyl groupsDennis P. Curran, Ann C. Abraham, and Hongtao LiuCite this: J. Org. Chem. 1991, 56, 14, 4335–4337Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/jo00014a001https://doi.org/10.1021/jo00014a001research-articleACS PublicationsRequest reuse permissionsArticle Views701Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Dual blockade of IL-6 and CTLA-4 regresses pancreatic tumors in a CD4 + T cell-dependent manner (2020)

Abstract Pancreatic ductal adenocarcinoma (PDAC) is exceptionally resistant to immune checkpoint inhibition (ICI). We previously reported that elevated systemic interleukin-6 (IL-6) and increased numbers of T cells positive for circulating cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) correlate with worse overall survival in patients with PDAC. We postulated that combined blockade of IL-6 and CTLA-4 would significantly enhance anti-tumor immune responses to PDAC. Dual blockade of IL-6 and CTLA-4 in immune competent mice bearing subcutaneously injected pancreatic tumors significantly inhibited tumor growth, accompanied by overwhelming T cell infiltration. Therapeutic efficacy was confirmed in an orthotopic murine model of pancreatic cancer and T cell depletion studies unveiled a unique dependence on CD4 + T cells for anti-tumor activity of dual IL-6 and CTLA-4 blockade. In vitro studies utilizing T cells from a TRP-1 transgenic mouse as an antigen-specific model system demonstrate this combination therapy elicits increased IFN-γ production by activated CD4 + T cells. Additionally, IFN-γ stimulation of pancreatic tumor cells in vitro profoundly increased tumor cell production of CXCR3 specific chemokines (CXCL10 and CXCL9). Further studies blocking CXCR3 in the presence of combined IL-6 and CTLA-4 blockade prevented orthotopic tumor regression, demonstrating a dependence on the CXCR3 axis for anti-tumor efficacy. We also found combination therapy increased intratumoral CD4 + T cells and elicited systemic changes in T-helper subsets. These data represent the first report of IL-6 and CTLA-4 blockade as a means to regress pancreatic tumors with defined operative mechanisms of efficacy. Given these results, this therapeutic combination has potential for immediate clinical translation. One Sentence Summary Blockade of interleukin-6 in pancreatic cancer enhances CTLA-4 immune checkpoint inhibition to regress tumors in a CD4 + T cell and CXCR3-dependent manner.