gebhart/patrepeval huggingface dataset:
The perpetuation of orthomyxoviruses and paramyxoviruses in Canadian waterfowl (1980)

A longitudinal survey of viruses in feral ducks from 1976 to 1978 in the Vermillion area of Alberta, Canada, has shown that influenza A viruses and paramyxoviruses are present year after year in these apparently healthy ducks. Influenza viruses were isolated most frequently each year from mallards, pintails, and blue-winged teals, but were not restricted to these species. During the 3-year survey, 1262 influenza viruses were isolated from 4827 ducks, revealing the high incidence of influenza infection, a finding which contrasts with the very low incidence found in ducks during migration through Tennessee.Many different influenza A viruses were detected in the ducks, including 27 different combinations of hemagglutinin and neuraminidase subtypes. These viruses encompass all but one of the known hemagglutinin and neuraminidase subtypes. The virus subtypes in the ducks varied from year to year; however, 6 of these 27 subtypes were present every year. The predominant subtype changed from Hav7Neq2 in 1976–1977 to Hav6N2 in 1978. Antigenic comparisons of current and previous Hav6 viruses isolated from ducks, turkeys, and a shearwater showed that antigenic drift occurs in avian influenza viruses.Paramyxoviruses occur in the Canadian ducks at a much lower frequency than influenza viruses; in 3 years, 69 paramyxoviruses were isolated and included two types: lentogenic NDV and Duck/Mississippi/75.These longitudinal studies indicate that the feral ducks in the study area of Canada are a perpetual reservoir of diverse influenza A viruses and paramyxoviruses.
Linaclotide Significantly Improves Post-Operative Ileus and Opiate-Induced Constipation in Rats (2006)

Purpose: Linaclotide acetate (MD-1100) is currently in Phase 2 clinical trials for the treatment of irritable bowel syndrome with constipation (IBS-C), chronic constipation and other gastrointestinal (GI) disorders. Linaclotide, a 14 amino acid peptide, acts by stimulating guanylate cyclase-C located on the intestinal epithelial surface and has been found to be minimally absorbed and well tolerated at the doses of up to 3 mg/day tested in Phase 1. Additionally, linaclotide has been found to exhibit the expected dose-related intestinal pharmacodynamic activity in normal healthy subjects. In the current study, linaclotide was assessed for efficacy in rat models of post-operative ileus and opiate-induced constipation. Methods: Female, CD rats (130–180g) were used in these studies. Post-operative ileus was induced by manual manipulation of the intestines following laparotomy. Opiate-induced constipation was produced following intraperitoneal dosing with morphine at 2.5 mg/kg. Animals were dosed orally with linaclotide or vehicle before receiving a charcoal meal used to track transit within the small intestine. Group numbers for each of the studies ranged from 8 to 10 rats. Results: In an in vivo model of post-operative ileus, linaclotide at a dose of 10ug/kg significantly accelerated transit (p≤ 0.01) compared to animals receiving vehicle alone. In the opiate-induced constipation model, linaclotide at doses of 25 and 50ug/kg significantly enhanced transit compared to animals receiving morphine (p= 0.004 and 0.002 respectively), while also returning transit to a rate comparable with animals not receiving morphine at doses as low as 12.5ug/kg (p= 0.426). Conclusions: In two different models of decreased intestinal transit, linaclotide treatment was associated with accelerated transit compared to control animals that received vehicle alone. These data support potential utility of linaclotide for the treatment of both post-operative ileus and opiate-induced constipation.
Triterpenoids from Eucalyptus camaldulensisDehnh. Tissue Cultures (2008)

Abstract A chemical study on tissue cultures from leaves and flowers of E. camaldulensis Dehnh . afforded the new natural product (2 α ,3 β )‐2,3,23‐trihydroxy‐13,28‐epoxyurs‐11‐en‐28‐one (dryobalanolide) together with the known pentacyclic triterpenoids: betulinic acid, oleanolic acid, ursolic acid, (2 α ,3 β )‐2,3,23‐trihydroxyolean‐12‐en‐28‐oic acid (arjunolic acid), (2 α ,3 β )‐2,3,23‐trihydroxyurs‐12‐en‐28‐oic acid (asiatic acid), (2 α )‐2‐hydroxyursolic acid, (2 α )‐2‐hydroxyoleanolic acid (maslinic acid), as well as β ‐sitosterol. The extracts and the isolated compounds were evaluated against eleven human pathogenic microorganisms, exhibiting a very interesting antibacterial spectrum of activities.
Patterns and Significance of PIM Kinases in Urothelial Carcinoma (2015)

A high percentage of urothelial carcinomas express Pim kinases. Pim expression differs in NILG, NIHG, and IHG lesions.
Stream analytics: data pre-processing and transformation (2014)

Continuous operation and data analysis are two of the distinguishing features of the stream processing paradigm. Arguably, the way in which SPAs employ analytics is what makes them invaluable to many businesses and scientific organizations.
Electronic Medical Record Review as a Surrogate to Telephone Follow-up to Establish Outcome for Diagnostic Research Studies in the Emergency Department (2005)

Under limited circumstances, accurate clinical follow-up for diagnostic studies conducted in the ED can be obtained by medical record review.
Growth and Yield Characters of Potato Genotypes Grown in Drought and Irrigated Conditions of Nepal (2015)

This experiment was conducted to assess the genotypic variation for the growth, yield and yield components of potato grown under drought and irrigated conditions at Hattiban Research Farm, Khumaltar during the summer cropping season (Feb.-May) of the two consecutive years (2013 and 2014). The results revealed that canopy cover, stem height and number of leavers were more sensitive to drought and the effect was more pronounced in early cultivar Desiree. Stem height and leaf number of plant were more (36% and 45%, respectively) reduced in Desiree than other genotypes. Mean tuber number decreased by 55% under drought condition. Drought stress reduced marketable tuber number by 79% as compared to irrigated treatment. Drought stress reduced the marketable tuber yield from 70% to 87%. The clones CIP 392242.25 and LBr-40 had relatively lower yield loss, and less drought susceptibility index under drought indicating their tolerance to drought in field condition. Further experiment is recommended to study the physiological parameters of these genotypes under different water and soil conditions. Int J Appl Sci Biotechnol, Vol 3(3): 513-519
A method for simultaneous nuclear immunofluorescence and DNA content quantitation using monoclonal antibodies and flow cytometry (1985)

A preparative technique for the two-parameter flow cytometric study of nuclear antigen expression is reported. This method employs a brief sequential treatment of cells at 4 degrees C first with 0.5% paraformaldehyde and second with 0.1% Triton X-100 in phosphate-buffered saline followed by cellular staining with indirect immunofluorescence and propidium iodide. Using this technique, cellular morphology is preserved, cell clumping is minimized, and high-quality indirect immunofluorescence and DNA staining are obtained with a minimum of nonspecific labeling. Utilizing nuclear antigen-specific monoclonal antibodies in conjunction with this technique, the cell-cycle phase-dependent expression of such antigens is examined. From these data, the utility of two-parameter flow cytometry in the identification and quantification of cell-cycle-dependent modulation of nuclear antigens is discussed.
Chemical Constituents of Cichorium intybus and their Inhibitory Effects against Urease and α-Chymotrypsin Enzymes (2011)

Phytochemical investigation of the aerial parts of Cichorium intybus L. resulted in the isolation and identification of two new natural metabolites, 2,6-di[but-3(E)-en-2-onyl]naphthalene (1), and 3,3',4,4'-tetrahydroxychalcone (2), along with nine known compounds. Their structures were determined by spectroscopic techniques including 1D and 2D NMR. The known compounds were identified as scopoletin (3), 4-hydroxyphenylacetic acid (4), 3-hydroxy-4-methoxybenzoic acid (5), 4,4'-dihydroxychalcone (6), 6,7-dihydroxycoumarine (7), 1-triacontanol (8), lupeol (9), beta-sitosterol (10), and beta-sitosterol-3-O-beta-glucopyranoside (11). Compounds 4-6 and 8 are reported for the first time from C. intybus. Compounds 2 and 3 showed weak inhibitory activities against urease and alpha-chymotrypsin enzymes, respectively.
Prospective comparison of helical CT and MR imaging in clinically suspected acute pulmonary embolism (1996)

The purpose of this study is to compare sensitivity and specificity of helical CT and MR imaging for detecting acute pulmonary embolism(PE). Patients who were suspected clinically of having PE were randomly assigned to undergo either helical contrast-enhanced CT or gradient-echo MR (if one modality was contraindicated, the patient was assigned to the other.) Patients were considered to have PE if they had: 1) high-probability V-Q scan and low clinical probability of PE; 2) pulmonary angiogram positive for PE. Patients were considered not to have PE if they had either:1)normal V-Q scan; 2) low probability V-Q scan and low clinical probability of PE; or 3) pulmonary angiogram negative for PE. The CT and MR images were read randomly and independently by five radiologists with varying levels of CT and MR experience. Twenty eight patients underwent CT and 25 MR. A total of 21 patients underwent pulmonary angiography (6 had PE, 15 did not have PE). Of the other 32 patients, 15 had high probability scan/high clinical probability and 17 had low probability scan/low clinical probability. For the five observers, the average sensitivity of CT was 75% and of MR 46%; the average specificity of CT was 89% and of MR 90%. Experience with vascular MR and enhanced CT influenced diagnostic accuracy. For the two vascular MR experts, average sensitivity and specificity of MR were 71% and 97%, and of CT 73% and 97%. In this pilot study, when CT and MR were interpreted with comparable expertise, they had similar accuracy for detecting pulmonary embolism.
ChemInform Abstract: MONOALKYLDERIVATE DER KOBALT(III)‐KOMPLEXE EINES VIERZAEHNIGEN MAKROCYCLISCHEN LIGANDEN MIT ALPHA‐DIIMIN‐GRUPPEN (1973)

Abstract Die Alkylderivate (II) wurden aus den Komplexen (I) bzw. (III) in einer Acet Methanol‐Mischung durch Reduktion zum Co(I)‐Derivat mit Hydridoboratio oder Na‐Amalgam und Weiterreaktion mit den Alkylhalogeniden dargestellt.
Application of Monodentate Secondary Phosphine Oxides, a New Class of Chiral Ligands, in Ir(I)‐Catalyzed Asymmetric Imine Hydrogenation. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Rapid virtual prototyping and dynamics analysis of a common rail injection system for gasoline engines (2009)

The topic of this article is the modelling, parameter estimation and analysis of a common rail direct injection system of a gasoline engine. First the system is described and the functional role of each element is highlighted. An analytical first-principles simulator of the system is developed, using a finite-difference approach. Model parameters are identified and the simulator is validated using real data. Using the validated simulator, an analysis of the system dynamics is developed. This analysis provides a deep insight in the trade-offs of the choice of some components of the injection system. It is shown how this approach can be very useful to make a 'virtual' (simulator-based) definition of the system. From the methodological point of view, the most interesting feature of the analysis presented in this article is the fact that mechanics, fluid-dynamics and control algorithms are analysed as a whole, in a genuine and modern 'co-design' approach.
Film formation from polystyrene–poly(butyl acrylate‐co‐methyl methacrylate) latex blends (2006)

Abstract We have employed steady sate fluorescence (SSF) and UV‐visible (UVV) techniques to determine the film formation behavior of latex blends. Blend films were prepared from mixtures of a high‐ T g pyrene (P) labeled polystyrene (PS) latex and a low‐ T g copolymer of poly(butyl acrylate‐ co ‐methyl methacrylate) (BuA/MMA4). Eleven different blend films were prepared in various hard/soft latex compositions at room temperature and annealed at elevated temperatures above glass‐transition ( T g ) temperature of polystyerene for 10 min. Fluorescence intensity ( I P ) from P was measured after each annealing step to monitor the stages of film formation. The evolution of transparency of latex films was monitored using photon transmission intensity, I tr . Film morphologies were examined by atomic force microscopy (AFM). A significant change occurs in both I P and I tr intensities at a certain critical weight fraction of hard latex ( R c = 0.3). Above R c , two distinct film formation stages, which are named as void closure and interdiffusion processes, were seen in fluorescence data. Transparency of the films was decreased with decreasing PS content, indicating that a phase separation process occurs between PS and BuA/MMA4 phases by thermal treatment, which results in turbid films. However, below R c , no change was observed in I P and I tr upon annealing, whereas transparency increased overall with increasing BuA/MMA4 ratio. We explained this result as the phase separation process between PS and BuA/MMA4 blends. These results were also confirmed by AFM pictures. Film formation stages above R c were modeled and related activation energies were calculated. POLYM. COMPOS., 27:431–442, 2006. © 2006 Society of Plastics Engineers
Solar Heat Load on the Vehicle Occupants (2016)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Vehicle occupants, unlike building occupants, are exposed to continuously varying, non-uniform solar heat load. Automotive manufacturers use photovoltaic cells based solar sensor to measure intensity and direction of the direct-beam solar radiation. Use of the time of the day and the position - latitude and longitude - of a vehicle is also common to calculate direction of the direct-beam solar radiation. Two angles - azimuth and elevation - are used to completely define the direction of solar radiation with respect to the vehicle coordinate system. Although the use of solar sensor is common in today’s vehicles, the solar heat load on the occupants, because of their exposure to the direct-beam solar radiation remains the area of in-car subjective evaluation and tuning. Since the solar rays travel in parallel paths, application of the ray tracing method to determine solar insolation of the vehicle occupants is possible. Calculating the solar exposure however requires the knowledge of geometry of the passenger compartment of a vehicle in addition to the direction of the direct-beam solar radiation. Geometry information includes 3D coordinates of the vehicle glasses and the passenger seating location. Planar surface approximation is used to represent both the glasses and the seats. Further the seat coordinates are shifted to obtain exposure of the occupants than the seats. Shifting of the seat coordinates is performed according to the thickness of chest and lap of an average adult. The solar exposure calculation also requires correction to the measured solar intensity. The correction is to account for attenuation of the solar radiation by the transmittance of the vehicle glasses. The solar heat load is then obtained by multiplying the occupant’s solar exposure area in m&lt;sup&gt;2&lt;/sup&gt; and the transmitted solar intensity in W/m&lt;sup&gt;2&lt;/sup&gt; for the given solar angles and vehicle geometry. The results of solar heat load so obtained are compared with the CFD Fluent data for a compact SUV.&lt;/div&gt;&lt;/div&gt;
The Prognostic Significance of Multiple Molecular Markers in Blood of Patients With Multimodal Treatment of Esophageal Cancer (2011)

Introduction: Human CABYR is a testis specific polymorphic calcium binding tyrosine phosphorylation regulative protein isolated from spermatozoa. This protein is localized to the sperm flagellum in association with the fibrous sheath; it can bind calcium after being phosphorylated during sperm capacitation. Six transcript variants of CABYR encoding five protein isoforms have been identified. Normally, CABYR is expressed in the human germ line but not in adult human tissues, thus, it is considered a cancer testis (CT) protein. A high frequency of expression in tumor tissues and restricted expression in normal tissues make CT proteins attractive cancer vaccine targets. Increased expression of CABYR a/b and c isoforms in lung cancers and isoforms c and d in brain tumors have been reported. The expression patterns of CABYR genes in colorectal cancer (CRC) are not well characterized. The aim of this study is to evaluate the expression of CABYR a/b and c in CRC tumors and to determine if they hold promise as vaccine targets. Method: Consenting CRC patients (pts) who underwent elective resection for whom tumor samples were available were included in the study. Demographic, clinical, and pathologic data were collected prospectively. Tissues were OCT embedded and stored at -80°C until analysis. Total purified RNA was isolated from tissue samples and cDNA synthesized. CABYR a/b and c expression was analyzed by quantitative PCR (QPCR) using the SYBR Green platform. Tumor and normal tissue expression levels were determined and compared as were tumor and testis CABYR expression levels. Tumors with expression levels 0.1% or more than the testis were considered positive. Expression of CABYR a/b and c in a set of normal human tissues was analyzed by RT-PCR. Results: A total of 47 paired CRC and normal tissue specimens (18 M/ 29 F, age 65+/-16.8) were studied (85% colon,15% rectal). Stage breakdown was as follows: Stage 2, 26; Stage 3, 19; and Stage 4, 2 pts. The percent of pts with a relative expression ratio of malignant to normal tissues (MN ratio) over 1 was 70% for CABYR a/b and 72% for CABYR-c. The percent with both a MN ratio over 1 and expression levels over 0.1% of testis was 23.4% for CABYR-a/b and 25.5% for CABYR-c. Except for very low expression of CABYR a/b in the brain, CABYR a/b or c was not expressed in normal tissues. Conclusion: RT-PCR analysis confirmed the frequent overexpression of CABYR a/b and c in most CRC tumors compared to adjacent normal tissues. In 23-26% of tumors expression was more than 0.1% of the expression level of testis. A larger and more diverse group of tumors (Stage 1-4) needs to be assessed to determine if CABYR expression correlates with T, N, or final tumor stage. Evaluation of blood for anti-CABYR antibodies is also needed. These results support CABYR as a potential therapeutic vaccine candidate in CRC.
Mechanism of Propylene Insertion Using Bis(phenoxyimine)-Based Titanium Catalysts:  An Unusual Secondary Insertion of Propylene in a Group IV Catalyst System. [J. Am. Chem. Soc. 2002, 124, 3614−3621]. (2002)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionMechanism of Propylene Insertion Using Bis(phenoxyimine)-Based Titanium Catalysts: An Unusual Secondary Insertion of Propylene in a Group IV Catalyst System. [J. Am. Chem. Soc. 2002, 124, 3614−3621].Phillip D. Hustad, Jun Tian, and Geoffrey W. CoatesCite this: J. Am. Chem. Soc. 2002, 124, 51, 15400Publication Date (Web):November 27, 2002Publication History Published online27 November 2002Published inissue 1 December 2002https://pubs.acs.org/doi/10.1021/ja025119hhttps://doi.org/10.1021/ja025119hcorrectionACS PublicationsCopyright © 2002 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views701Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (24 KB) Get e-Alertsclose Get e-Alerts
Simultaneous Wireless Information and Power Transfer by Continuous-Phase Modulation (2020)

A new concept of simultaneous wireless information and power transfer (SWIPT) is proposed, based on multiplexing a continuous-phase modulated (CPM) information transfer signal and a multitone power transfer (PT) signal. The tones of the PT signal have frequencies falling into low-power sub-bands and/or spectral null frequencies of the CPM signal. Therefore, the interference of the PT signal to the CPM signal is minimized and, simultaneously, the CPM and PT signals can be separated by the corresponding complementary filters in the receiver. Numerical evaluations show that the proposed PT signal design practically entails a negligible loss of CPM detection performance.
F-18 labeled PEG stilbene derivatives as PET imaging agents for Alzheimer’s disease (2006)

625 Objectives: It is generally accepted that accumulation of beta-amyloid (Abeta) plaques in the brain is a major risk factor associated with Alzheimer’s disease (AD). Thus, development of 18F labeled imaging agents targeting Abeta plaques will be useful for improving diagnosis and monitoring disease progression. Previously, we have reported that a C-11 and F-18 labeled stilbene derivatives to be potential imaging agents for Abeta plaques. In this study, we further examined the effect of fluoro-ethylene-glycol (FPEG) length attached to a stilbene backbone structure on the in vitro and in vivo properties of ligands. Methods: F-18 labeled polyethylene glycol (FPEG) derivatives of 4’-N-methyl-4-hydroxyl-stilbenes designed to target Abeta plaques in the brain were prepared. In these series of compounds, F-18 is linked to the stilbene through a PEG chain, of which the number of PEG groups ranges from 2 to 8. Binding affinities were assessed in postmortem AD brain homogenates. Specific plaque labeling was evaluated in the brain sections of AD patients via in vitro autoradiography. In vivo pharmacokinetic properties were evaluated in normal mice. Results: High affinities (Ki = 2-9 nM) of novel FPEG-stilbenes (n = 2-8) targeting Abeta plaques were observed (Table 1). Additionally, autoradiography of 18F labeled FPEG stilbene derivatives (n = 2 to 5) in AD brain sections displayed excellent labeling of Abeta plaques. The distribution was distinctively reflecting the accumulation of plaques in the cortical region of AD brain. In vivo biodistribution of the ligands in mice exhibited excellent initial brain penetration for n = 2-5 (6.6 to 8.1 %dose/g at 2 min) and moderate rate of washout from the brain tissue; while when n = 6 and 8 the brain uptake displayed a dramatic reduction on brain uptake (0.7 and 0.9 %dose/g at 2 min in normal mice). Conclusions: These results suggest that the novel series ligands may be useful as a platform for developing novel F-18 imaging agents targeting Abeta plaques. Research Support (if any): NIH AG-0022559
Chiral molecular fluoridosilicates and their twin polymerization for the preparation of fluorine-doped mesoporous silica and microporous carbon (2018)

The synthesis of organic–inorganic hybrid materials, microporous carbon and fluorine-doped mesoporous silica by the twin polymerization of pentacoordinated fluoridosilicates is reported.