gebhart/patrepeval huggingface dataset:
Foams Made of Engineered Recombinant Spider Silk Proteins as 3D Scaffolds for Cell Growth (2016)

Materials for tissue engineering have to be biocompatible and have to support cell adhesion, proliferation and differentiation. Additionally, in case of soft tissue engineering the mechanical properties have to accommodate that of the tissue with mechanical integrity until the artificial scaffold is replaced by natural extracellular matrix. In case of artificial 3D scaffolds, it is of critical importance to be able to tune the mechanical properties, the inner free volume (i.e., pore size) and degradation behavior of the employed biomaterial. Here, the potential of recombinant spider silk proteins was evaluated concerning their processing into and application as 3D scaffolds for soft tissue engineering. Highly porous foams made of the recombinant spider silk protein eADF4(C16) and a variant containing an RGD motif were fabricated by salt leaching yielding mechanically robust scaffolds. In contrast to other salt-leached silk scaffolds, the swelling behavior of these scaffolds was low, and the mechanical properties in the range of soft tissues. The pore size and porosity of the foams could be adjusted by the salt crystal size. Fibroblasts adhered and proliferated well in foams made of the spider silk RGD variant but not in the foams of the nonmodified one.
Effects of Nitriding-Quenching and Carburizing-Quenching on Wear Properties of Industrial Pure Iron (2018)

Abstract The wear properties of industrial pure iron treated by nitriding-quenching and carburizing-quenching were investigated. Both the nitrogen martensite and carbon martensite produced by each treatment exhibited the same high degree of wear resistance. The results of sliding tests showed that the nano-indentation hardness near the surfaces of both samples had increased. The surface hardening of the nitrogen martensite was more noticeable than that of the carbon martensite. EBSD analysis revealed that plastic strain had been induced on a relatively large scale (around 20 μm) after sliding in the case of the nitrogen martensite. It was found that the high wear resistance of the nitrogen martensite led to strain hardening through the effect of the load applied in the sliding test.
Genetic characterization of equine arteritis virus during persistent infection of stallions (2004)

Equine arteritis virus (EAV) causes a persistent infection of the reproductive tract of carrier stallions. The authors determined the complete genome sequences of viruses (CW96 and CW01) that were present 5 years apart in the semen of a carrier stallion (CW). The CW96 and CW01 viruses respectively had only 85.6 % and 85.7 % nucleotide identity to the published sequence of EAV (EAV030). The CW96 and CW01 viruses had two 1 nt insertions and a single 1 nt deletion in the leader sequence, and a 3 nt coding insertion in ORF1a; thus their genomes included 12 708 nt as compared to the 12 704 nt in EAV030. Variation between viruses present in the semen of stallion CW and EAV030 was especially marked in the replicase gene (ORF1a and 1b), and the greatest variation occurred in the portion of ORF1a encoding the nsp2 protein. The ORFs 3 and 5, which respectively encode the GP3 and GP5 envelope proteins, showed greatest variation amongst ORFs encoding structural EAV proteins. Comparative sequence analyses of CW96 and CW01 indicated that ORFs 1a, 1b and 7 were highly conserved during persistent infection, whereas there was substantial variation in ORFs 3 and 5. Although the variation that occurs in ORF5 results in the emergence of novel phenotypic viral variants as determined by neutralization assay, all variants were neutralized by high-titre polyclonal equine antisera, suggesting that immune evasion is unlikely to be responsible for the establishment of persistent EAV infection of carrier stallions. Northern blot analyses of RNA extracted from cell culture propagated viruses isolated from 10 different persistently infected stallions failed to demonstrate any large genomic deletions, suggesting that defective interfering particles are also unlikely to be important in either the maintenance or clearance of persistent EAV infection of the reproductive tract of carrier stallions.
Evaluation of the Anonymity and Utility of De-Identified Clinical Data Based on Japanese Anonymization Criteria (2017)

We analyze the deterioration of clinical data quality due to anonymization. The result shows that data quality remained high with micro-aggregation and also verify the availability of noise addition to prevent illegal re-identification by matching another personal data.
Lessons learned from the deployment of a smartphone-based access-control system (2007)

Grey is a smartphone-based system by which a user can exercise her authority to gain access to rooms in our university building, and by which she can delegate that authority to other users. We present findings from a trial of Grey, with emphasis on how common usability principles manifest themselves in a smartphone-based security application. In particular, we demonstrate aspects of the system that gave rise to failures, misunderstandings, misperceptions, and unintended uses; network effects and new flexibility enabled by Grey; and the implications of these for user behavior. We argue that the manner in which usability principles emerged in the context of Grey can inform the design of other such applications.
A CMOS temperature sensor with a voltage-calibrated inaccuracy of &#x00B1;0.15&#x00B0;C (3&#x03C3;) from &#x2212;55 to 125&#x00B0;C (2012)

This paper describes an energy-efficient CMOS temperature sensor intended for use in RFID tags. The sensor achieves an inaccuracy of ±0.15°C (3σ) over the military temperature range (-55 to 125°C) and dissipates only 27nJ/conversion: over 20× less than a previous sensor with comparable accuracy and resolution [2]. This energy efficiency is achieved by the use of an improved charge-balancing scheme and a zoom ADC that combines a 5b coarse SAR conversion with a 10b fine 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> -order ΔΣ conversion.
P-glycoprotein-mediated secretion of a fluorescent cyclosporin analogue by teleost renal proximal tubules (1995)

The transport of a fluorescent cyclosporin analogue was measured in killifish (Fundulus heteroclitus) proximal tubules by means of epifluorescence microscopy and digital image analysis. Renal cells rapidly accumulated the cyclosporin analogue from the medium and attained steady state within 60 min; luminal fluorescence increased over the first 60-90 min. At steady state, luminal fluorescence intensity was two to three times higher than cellular. Cellular fluorescence intensity was a linear function of medium substrate concentration and was not affected by any treatment used. In contrast, luminal fluorescence exhibited a saturable component as the medium concentration of the cyclosporin was increased. Secretion into the lumen was blocked by metabolic inhibitors, vanadate, other cyclosporins, such as cyclosporin A and cyclosporin G, and substrates for P-glycoprotein (verapamil, vinblastine, and quinine) but not by substrates for the renal organic anion or organic cation transport systems, such as p-aminohippurate or tetraethylammonium. The data are consistent with the fluorescent cyclosporin analogue entering proximal tubule cells by simple diffusion and then being pumped into the tubular lumen by P-glycoprotein.
LIGAMENT INJURIES ASSOCIATED WITH PHYSEAL FRACTURES ABOUT THE KNEE (1983)

A retrospective study of 29 cases of epiphyseal plate fractures about the knee revealed 14 patients with ligament instability at follow-up evaluation an average of 66 months after injury. Distal femoral physeal fractures had occurred in 16 of the 29 patients. Six of these patients had ligament insufficiency, which was recognized by positive anterior drawer and Lachman tests in all six and laxity to valgus stress in one. Proximal tibial physeal fractures were noted in 13 of the 29 patients. Eight of these patients had ligament laxity; anterior drawer and Lachman tests were positive in five, and laxity with valgus stress was present in four patients. It is concluded that because 14 of 29 patients (48%) had ligament insufficiency at follow-up evaluation, physeal fracture about the knee does not exclude ligament damage and, in fact, is associated with a high incidence of ligament injury. Furthermore, a complex proximal tibial physeal fracture associated with medial collateral ligament rupture is described for the first time. This resulted in medial collateral ligament insufficiency, genu valgus, and early degenerative changes. A treatment plan of primary ligament repair, fracture reduction, and follow-up evaluation to skeletal maturity is suggested for this unique fracture.
Predictive value of T1 mapping in cervical cancer recurrence after treatment (2023)

We investigated the feasibility of T1-mapping to predict cervical cancer (CC) recurrence after treatment. Our results show that quantitative T1 values of the primary tumor could effectively predict the CC recurrence after surgery or concurrent chemoradiotherapy (CCRT). These findings suggest that the T1-mapping method could be valuable for evaluating CC recurrence after treatment, and native T1 values of the primary tumor could predict cervical cancer recurrence.
Understanding Ligand Binding to G-Protein Coupled Receptors Using Multiscale Simulations (2019)

Human G-protein coupled receptors (GPCRs) convey a wide variety of extracellular signals inside the cell and they are one of the main targets for pharmaceutical intervention. Rational drug design requires structural information on these receptors; however, the number of experimental structures is scarce. This gap can be filled by computational models, based on homology modeling and docking techniques. Nonetheless, the low sequence identity across GPCRs and the chemical diversity of their ligands may limit the quality of these models and hence refinement using molecular dynamics simulations is recommended. This is the case for olfactory and bitter taste receptors, which constitute the first and third largest GPCR groups and show sequence identities with the available GPCR templates below 20%. We have developed a molecular dynamics approach, based on the combination of molecular mechanics and coarse grained (MM/CG), tailored to study ligand binding in GPCRs. This approach has been applied so far to bitter taste receptor complexes, showing significant predictive power. The protein/ligand interactions observed in the simulations were consistent with extensive mutagenesis and functional data. Moreover, the simulations predicted several binding residues not previously tested, which were subsequently verified by carrying out additional experiments. Comparison of the simulations of two bitter taste receptors with different ligand selectivity also provided some insights into the binding determinants of bitter taste receptors. Although the MM/CG approach has been applied so far to a limited number of GPCR/ligand complexes, the excellent agreement of the computational models with the mutagenesis and functional data supports the applicability of this method to other GPCRs for which experimental structures are missing. This is particularly important for the challenging case of GPCRs with low sequence identity with available templates, for which molecular docking shows limited predictive power.
AN ECONOMETRIC ANALYSIS OF THE U.S. SHRIMP MARKET (1982)

Demand and Price Analysis, Marketing
Induction by Cationic Antimicrobial Peptides and Involvement in Intrinsic Polymyxin and Antimicrobial Peptide Resistance, Biofilm Formation, and Swarming Motility of PsrA in Pseudomonas aeruginosa (2008)

ABSTRACT Pseudomonas aeruginosa is an important opportunistic pathogen that causes infections that can be extremely difficult to treat due to its high intrinsic antibiotic resistance and broad repertoire of virulence factors, both of which are highly regulated. It is demonstrated here that the psrA gene, encoding a transcriptional regulator, was upregulated in response to subinhibitory concentrations of cationic antimicrobial peptides. Compared to the wild type and the complemented mutant, a P. aeruginosa PAO1 psrA ::Tn 5 mutant displayed intrinsic supersusceptibility to polymyxin B, a last-resort antimicrobial used against multidrug-resistant infections, and the bovine neutrophil antimicrobial peptide indolicidin; this supersusceptibility phenotype correlated with increased outer membrane permeabilization by these agents. The psrA mutant was also defective in simple biofilm formation, rapid attachment, and swarming motility, all of which could be complemented by the cloned psrA gene. The role of PsrA in global gene regulation was studied by comparing the psrA mutant to the wild type by microarray analysis, demonstrating that 178 genes were up- or downregulated ≥2-fold ( P ≤ 0.05). Dysregulated genes included those encoding certain known PsrA targets, those encoding the type III secretion apparatus and effectors, adhesion and motility genes, and a variety of metabolic, energy metabolism, and outer membrane permeability genes. This suggests that PsrA might be a key regulator of antimicrobial peptide resistance and virulence.
Addition of a Phosphaalkyne to Metal‐Metal Multiple Bonds (1983)

Abstract The complete manuscript of this communication appears in: Angew. Chem. Suppl. 1983 , 501. DOI: 10.1002/anie.198305010
RaftLib: A C++ template library for high performance stream parallel processing (2016)

Stream processing is a compute paradigm that has been around for decades, yet until recently has failed to garner the same attention as other mainstream languages and libraries (e.g. C++, OpenMP, MPI). Stream processing has great promise: the ability to safely exploit extreme levels of parallelism to process huge volumes of streaming data. There have been many implementations, both libraries and full languages. The full languages implicitly assume that the streaming paradigm cannot be fully exploited in legacy languages, while library approaches are often preferred for being integrable with the vast expanse of extant legacy code. Libraries, however are often criticized for yielding to the shape of their respective languages. RaftLib aims to fully exploit the stream processing paradigm, enabling a full spectrum of streaming graph optimizations, while providing a platform for the exploration of integrability with legacy C/C++ code. RaftLib is built as a C++ template library, enabling programmers to utilize the robust C++ standard library, and other legacy code, along with RaftLib’s parallelization framework. RaftLib supports several online optimization techniques: dynamic queue optimization, automatic parallelization, and real-time low overhead performance monitoring.
Investigations of the [2,3]‐Sigmatropic Rearrangements of Vinylazidridines and Allylic Amines (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
SCnS Linear Chain Production by Direct Laser Ablation (2003)

Cumulenic polycarbons SCnS (n = 2−27) were generated by laser ablation of mixtures of elemental carbon and sulfur. The resulting molecules were analyzed in a time-of-flight mass spectrometer. The spectra exhibited ideal odd/even intensity alternation attributed to their relative stability and the formation mechanism of the clusters. The structures and energies of the neutral and charged carbon chains capped with two sulfur atoms were also studied by density functional theory. The computational results were consistent with the experimental observations. Evidence of sulfur poisoning of fullerene formation was observed and explained in terms of one of the existing models for fullerene formation and growth.
The Other-Transport Extension: Arbitrary Transports over CONNECT-UDP (1998)

This document describes an extension to the HTTP CONNECT-UDP method
[CONNECTUDP] that supports tunneling of other transport protocols, as
long as the first four octets of those protocols encode the source and
destination ports.
Order and Disorder in Symmetric Diblock Copolymer Melts (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrder and Disorder in Symmetric Diblock Copolymer MeltsJeffrey H. Rosedale, Frank S. Bates, Kristoffer Almdal, Kell Mortensen, and George D. WignallCite this: Macromolecules 1995, 28, 5, 1429–1443Publication Date (Print):February 1, 1995Publication History Published online1 May 2002Published inissue 1 February 1995https://pubs.acs.org/doi/10.1021/ma00109a014https://doi.org/10.1021/ma00109a014research-articleACS PublicationsRequest reuse permissionsArticle Views1309Altmetric-Citations187LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Vertically aligned laser sliced MWCNTs (2019)

Applications of multi-walled carbon nanotubes (MWCNTs) benefit from the availability of specific lengths of the material while keeping the outer walls pristine, for example, for applications requiring vertically aligned tubes. To this end, a simple and effective continuous flow 'top down' process to control the length of sliced MWCNTs has been developed using a vortex fluidic device (VFD) coupled with a 1064 nm pulse laser, with the process in the absence of chemicals and any auxiliary substances. Three different length distributions of the sliced MWCNTs, centered at 75 ± 2.1 nm, 300 ± 1.8 nm and 550 ± 1.4 nm, have been generated with the length depending on the VFD operating parameters and laser energy, with the processing resulting in a decrease in side wall defects of the material. We also show the ability to vertically self assemble short MWCNTs on a silicon substrate with control of the surface density coverage using a simple dipping and rinsing method.
Si Incorporation into AsSeGe Chalcogenides for High Thermal Stability, High Endurance and Extremely Low Vth Drift 3D Stackable Cross-Point Memory (2020)

By incorporating Si into AsSeGe system, we demonstrate a 3D stackable OTS+PCM memory in a 1k by 1k cross-point memory array with extremely low V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">tS</sub> drift (~0V after 3 days from programming), wide V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">tS</sub> /V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">tR</sub> window (>2V main distribution memory window), high endurance (>2E11 cycles), excellent I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">OFF</sub> and thermal stability. So far, attempts to improve the thermal stability of AsSeGe system sacrifice I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">OFF</sub> and cycling endurance. We show that Si incorporation relaxes this trade-off and can greatly improve the thermal stability and cycling endurance while also achieving good I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">OFF</sub> . In particular the I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">OFF</sub> of AsSeGeSi selector is improved over the AsSeGe system for films of 20 nm.
Value of whole breast magnetic resonance elastography added to MRI for lesion characterization (2017)

The purpose of this work was to assess the diagnostic value of magnetic resonance elastography (MRE) in addition to MRI to differentiate malignant from benign breast tumors, and the feasibility of performing MRE on the whole breast. MRE quantified biomechanical properties within the entire breast (50 slices) using an 11 min acquisition protocol at an isotropic image acquisition resolution of 2 × 2 × 2 mm<sup>3</sup> . Fifty patients were included. Finally, 43 patients (median age 52) with a suspect breast lesion detected by mammography and/or ultrasound were examined by MRI and MRE at 1.5 T. The viscoelastic parameters, i.e. elasticity (G<sub>d</sub> ), viscosity (G<sub>l</sub> ), the magnitude of the complex shear modulus Gd2+Gl2, and the phase angle y=2πatanGlGd, were measured via MRE and correlated with MRI Breast Imaging-Reporting and Data System (BI-RADS) score, histological type, and histological grade. Stroma component and angiogenesis were also correlated with viscoelastic properties. In the 43 lesions, G<sub>d</sub> decreased and y increased with the MRI BI-RADS score (p<sub>Gd</sub> = 0.02, p<sub>y</sub> = 0.002), whereas (G<sub>l</sub> ) and y were increased in malignant lesions (p<sub>Gl</sub> = 0.045, p<sub>y</sub> = 0.0004). The area under the curve increased from 0.84 for MRI BI-RADS alone to 0.92 with the MRI BI-RADS and y (AUC increase +0.08; 95% CI (-0.003; 0.16)). Lesion characterization using the y parameter increased the diagnostic accuracy. The phase angle y was found to have a significant role (p = 0.01) in predicting malignancy independently of the MRI BI-RADS. Interestingly, histological analysis showed no correlation between viscoelastic parameters and percentage and type of stroma, CD34 quantification of vessels, or histological grade. The combination of MRE and MRI improves the diagnostic accuracy for breast lesions in the studied cohort. In particular, the phase angle y was found to have a significant role in predicting malignancy in addition to BI-RADS.
Live cell refractometry using Hilbert phase microscopy (2006)

Using Hilbert phase microscopy developed in our laboratory, we determined the average refractive index of suspended epithelial cells. The technique requires no preparation and can be easily automated and integrated with flow cytometry.
Matrix Representation of Polymer Chain Size Distributions, 3 – Case Studies for Linear Polymerization Mechanisms at Transient Conditions (2008)

Abstract The mass balance equations used to describe different polymerization systems are represented and analyzed with the help of a general matrix framework previously developed. Some of its properties were presented in previous works and are illustrated here in three examples. The first example regards the dynamics of a copolymerization reactor. It is shown that terminal and penultimate models may predict qualitatively different responses in batch reactions. The second example also regards the dynamics of copolymerization reactions. It is shown how manipulation of initial conditions and monomer feed rates can be used to keep copolymer composition constant throughout the batch. The third example concerns the existence of oscillating chain size distributions when there are multiple monomer insertion steps. magnified image