gebhart/patrepeval huggingface dataset:
Multiscale and multiphysics inﬂuences on ﬂuids in unconventional reservoirs: Modeling and simulation (2022)

Unconventional reservoir resources are important to supplement energy consumption and maintain the balance of supply and demand in the oil and gas market. However, due to the complex geological conditions, it is a signiﬁcant challenge to develop unconventional reservoirs efﬁciently and economically. At present, unconventional reservoirs are exten-sively studied, covering a wide range of areas, with special attention to the multiscale characterization of pore structures and fracture networks, description of complex ﬂuid transport mechanisms, mathematical modeling of ﬂow properties, and coupled analysis with multiphysics ﬁelds. This work brieﬂy describes the multiscale and multiphysics inﬂuences on ﬂuids in unconventional reservoirs, and the modeling and simulation work conducted to analyze them, with the aim to provide some theoretical basis for enhanced recovery from these geo-energy resources. The present article also aims to enhance the community’s knowledge of other potential utilizations associated with some unconventional reservoirs, specially related to environmentally-driven projects, including permanent greenhouse gas storage and cyclic underground energy storage. Cited as: Cai, J., Wood, D. A., Hajibeygi, H., Iglauer, S. Multiscale and multiphysics inﬂuences on ﬂuids in unconventional reservoirs: Modeling and simulation. Advances in Geo-Energy Research, 2022, 6(2): 91-94. https://doi.org/10.46690/ager.2022.02.01
Outpatient Percutaneous Nephrostolithotomy (1986)

Technical advances and operator experience have resulted in a rapid and marked streamlining of the percutaneous approach to renal calculi. The development of nephrostomy tract balloon dilators, improved grasping instruments and the use of assisted local anesthesia have been integral in reducing the morbidity and cost of the procedure. We report our initial favorable experience in the use of percutaneous stone removal on an outpatient basis. All 5 patients underwent an uncomplicated 1-stage stone removal. Cost for outpatient percutaneous stone removal was substantially less than for surgery or extracorporeal shock wave lithotripsy.
Improved reliability of rarely switching CMOS circuits in ULSI devices (2012)

In this work, novel configurations of rarely switching ULSI I/O circuits, which provide a "refresh" operation allowing for temporal bias removal without any changes in the logic state or electrical characteristics of these circuits, are presented. This bias removal significantly reduces the aging of the circuits and allows for the lessening of design timing margins, thus reducing the overall design costs.
Additions and Corrections - Polarized Electronic Spectroscopy of Molecules Oriented by a Nematic Liquid Crystal (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdditions and Corrections - Polarized Electronic Spectroscopy of Molecules Oriented by a Nematic Liquid CrystalGerald Ceasar and Harry GrayCite this: J. Am. Chem. Soc. 1969, 91, 14, 4017Publication Date (Print):July 1, 1969Publication History Published online26 April 2004Published inissue 1 July 1969https://pubs.acs.org/doi/10.1021/ja01042a608https://doi.org/10.1021/ja01042a608research-articleACS PublicationsRequest reuse permissionsArticle Views18Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fluorescence in situ Hybridization (FISH) as a Method to Detect Aneuploid Cells (1997)

FISH is an alternative technique for noninvasive prenatal diagnosis. The sensitivity and specificity of FISH probes may play a crucial role in the accuracy of prenatal diagnosis.
Bluemergency: Mediating Post-disaster Communication Systems using the\n Internet of Things and Bluetooth Mesh (2019)

Mobile devices have shown to be very useful during and post disaster. If the\ncommunication infrastructure breaks down, however, they become almost useless\nas most services rely on Internet connectivity. Building post-disaster networks\nbased purely on smartphones remains a challenging task, and, as of today, no\npractical solutions exist. The rapidly growing Internet of Things (IoT) offers\nthe possibility to improve this situation. With an increase in smart spaces\nsuch as smart homes and smart offices, we move towards digital cities that are\ndeeply penetrated by IoT technology. Many IoT devices are battery powered and\ncan aid in mediating an emergency network. In scenarios where the electrical\ngrid is still operational, yet communication infrastructure failed, non-battery\npowered IoT devices can similarly help to relief congestion or build a backup\nnetwork in case of cyber attacks. With the recent release of the Bluetooth Mesh\nstandard, a common interface between mobile devices and the IoT has become\navailable. The key idea behind this standard is to allow existing and new\ndevices to build large-scale multi-hop sensor networks. By enabling hundreds of\ndevices to communicate with each other, Bluetooth Mesh (BT MESH) becomes a\npractical technical solution for enabling communication post disaster. In this\npaper, we propose a novel emergency network concept that utilises the parts of\ndigital cities that remains operational in case of disaster, thus mediating\nlarge-scale post-disaster device-to-device communication. Since the Bluetooth\nMesh standard is backwards compatible to Bluetooth 4.0, most of todays mobile\ndevices can join such a network. No special hardware or software modifications\nare necessary, especially no jail-breaking of the smartphones.\n
“Beaded” Bimetallic Nanowires: Wiring Nanoparticles of Metal 1 Using Nanowires of Metal 2 (2003)

Aligned metal nanoparticles are connected using a second metal to produce bimetallic wires. The nanoparticles are electrodeposited along the step edges of a highly oriented graphite surface and, after being given a protective coating, joined by long nanowires which are also electrodeposited. Beaded structures are produced, such as the nickel/molybdenum oxide wire shown the Figure.
Isolation and identification of l-dopa decarboxylase as a protein that binds to and enhances transcriptional activity of the androgen receptor using the repressed transactivator yeast two-hybrid system (2003)

The AR (androgen receptor) is a ligand-regulated transcription factor, which belongs to the steroid receptor family and plays an essential role in growth and development of the prostate. Transcriptional activity of steroid receptors is modulated by interaction with co-regulator proteins and yeast two-hybrid analysis is commonly used to identify these steroid receptor-interacting proteins. However, a limitation of conventional two-hybrid systems for detecting AR protein partners has been that they only allow for analysis of the ligand- and DNA-binding domains of the receptor, as its NTD (N-terminal domain) possesses intrinsic transactivation activity. To identify AR N-terminus-interacting proteins, its NTD was used in the RTA (repressed transactivator) system, which is specifically designed for transactivator bait proteins and was shown to be suitable for two-hybrid analysis with the AR NTD. DDC (L-dopa decarboxylase) was detected multiple times as a novel AR-interacting protein, which was subsequently confirmed in vitro and in vivo. Furthermore, transient transfection of DDC in prostate cancer cells strongly enhanced ligand-dependent AR transcriptional activity, an effect that was antagonized using high concentrations of the anti-androgen bicalutamide. Glucocorticoid receptor activity was also strongly enhanced with DDC co-transfection, while oestrogen receptor activity was only mildly affected. Together, our data demonstrate that DDC interacts with AR to enhance steroid receptor transactivation, which may have important implications in prostate cancer progression.
Time-resolved Quantitative Proteome Analysis of In Vivo Intestinal Development (2010)

Postnatal intestinal development is a very dynamic process characterized by substantial morphological changes that coincide with functional adaption to the nutritional change from a diet rich in fat (milk) to a diet rich in carbohydrates on from weaning. Time-resolved studies of intestinal development have so far been limited to investigation at the transcription level or to single or few proteins at a time. In the present study, we elucidate proteomic changes of primary intestinal epithelial cells from jejunum during early suckling (1-7 days of age), middle suckling (7-14 days), and weaning period (14-35 days) in mice, using a label-free proteomics approach. We show differential expression of 520 proteins during intestinal development and a pronounced change of the proteome during the middle suckling period and weaning. Proteins involved in several metabolic processes were found differentially expressed along the development. The temporal expression profiles of enzymes of the glycolysis were found to correlate with the increase in carbohydrate uptake at weaning, whereas the abundance changes of proteins involved in fatty acid metabolism as well as lactose metabolism indicated a nondiet driven preparation for the nutritional change at weaning. Further, we report the developmental abundance changes of proteins playing a vital role in the neonatal acquisition of passive immunity. In addition, different isoforms of several proteins were quantified, which may contribute to a better understanding of the roles of the specific isoforms in the small intestine. In summary, we provide a first, time-resolved proteome profile of intestinal epithelial cells along postnatal intestinal development.
An energy-efficient readout method for piezoresistive differential pressure sensors (2017)

This paper describes a low power and low noise circuit for resistive Wheatstone bridge sensor readout. The proposed readout exploits the bridge configuration of the sensor by embedding it into a second-order continuous-time sigma delta modulator (RC CTΔΣM). By directly digitizing the output signal of a Wheatstone bridge in the current mode, the noise performance is dominated by the operational transconductance amplifier (OTA) in the first integrator. The proposed readout is designed in a 0.35 μm CMOS technology. Simulation results show that it achieves an input referred noise power spectral density (PSD) of 4.2 nV/√Hz with a current consumption of 860 μA from a 5 V voltage supply. This represents a noise efficiency factor (NEF) of 4.7.
On Chip Analysis of CNS Lymphoma in Cerebrospinal (2015)

Molecular profiling of central nervous system lymphomas in cerebrospinal fluid (CSF) samples can be challenging due to the paucicellular and limited nature of the samples. Presented herein is a microfluidic platform for complete CSF lymphoid cell analysis, including single cell capture in sub-nanoliter traps, and molecular and chemotherapeutic response profiling via on-chip imaging, all in less than one hour. The system can detect scant lymphoma cells and quantitate their kappa/lambda immunoglobulin light chain restriction patterns. The approach can be further customized for measurement of additional biomarkers, such as those for differential diagnosis of lymphoma subtypes or for prognosis, as well as for imaging exposure to experimental drugs.
Automatic Generation of Parasitic Constraints for PerformanceConstrained Physical Design of Analog Circuits (2009)

A new design methodology for the physical design of analog circuits is proposed. The methodology is based on the automatic generation of constraints on parasitics introduced during the layout phase from constraints on the functional performance of the circuit. In this novel performance-constrained approach, the parasitic constraints drive the layout tools to reduce the need for further layout iterations. Parasitic constraint generation involves 1) generation of a set of bounding constraints on the critical parasitics of a circuit to provide maximum flexibility to the layout tools while meeting the performance constraints; and 2) deriving a set of matching constraints on the parasitics from matched-node-pair and matched-branch-pair information in differential circuits. Constraint generator PARCAR is described and results presented for test circuits.
Molecular elucidation of drug-induced abnormal assemblies of the hepatitis B virus capsid protein by solid-state NMR (2023)

Hepatitis B virus (HBV) capsid assembly modulators (CAMs) represent a recent class of anti-HBV antivirals. CAMs disturb proper nucleocapsid assembly, by inducing formation of either aberrant assemblies (CAM-A) or of apparently normal but genome-less empty capsids (CAM-E). Classical structural approaches have revealed the CAM binding sites on the capsid protein (Cp), but conformational information on the CAM-induced off-path aberrant assemblies is lacking. Here we show that solid-state NMR can provide such information, including for wild-type full-length Cp183, and we find that in these assemblies, the asymmetric unit comprises a single Cp molecule rather than the four quasi-equivalent conformers typical for the icosahedral T = 4 symmetry of the normal HBV capsids. Furthermore, while in contrast to truncated Cp149, full-length Cp183 assemblies appear, on the mesoscopic level, unaffected by CAM-A, NMR reveals that on the molecular level, Cp183 assemblies are equally aberrant. Finally, we use a eukaryotic cell-free system to reveal how CAMs modulate capsid-RNA interactions and capsid phosphorylation. Our results establish a structural view on assembly modulation of the HBV capsid, and they provide a rationale for recently observed differences between in-cell versus in vitro capsid assembly modulation.
Development of a superhydrophobic electrospun poly(vinylidene fluoride) webviaplasma etching and water immersion for energy harvesting applications (2018)

Smart textiles have been enormously developed recently, but attachment of batteries and low washing resistance are the major challenges in the development of wearable smart textiles. However, piezoelectric materials harvesting energy from mechanical action can be readily integrated with smart textiles and can replace conventional batteries. Therefore, energy harvesters with poly(vinylidene fluoride) (PVDF) were fabricated by the electrospinning process. In addition, simple CF<sub>4</sub> plasma etching followed by water immersion of the electrospun PVDF webs resulted in superhydrophobicity, with a water contact angle of 169.8 ± 1.5°, a water shedding angle of 4.7 ± 1.8°, and self-cleaning properties. This would decrease the number of washing cycles during use and increase the durability of the smart textile. X-ray photoelectron spectroscopy indicated that metals were co-deposited as etch-resisting masks to fabricate a nanostructure during plasma etching and were removed by water immersion. The piezoelectric performance of the superhydrophobic electrospun PVDF web showed a higher peak-to-peak output voltage of 3.50 V than the untreated electrospun PVDF web (2.86 V). Furthermore, the breathability of the superhydrophobic PVDF web was remarkably higher than those of the PVDF film. Therefore, the new flexible electrospun PVDF web with superhydrophobicity and piezoelectricity has significant potential as energy harvesters in wearable smart textiles.
A Hybrid Submodular Optimization Approach to Controlled Islanding with Heterogeneous Loads (2022)

Cascade failures, in which the failure of generators or transmission lines causes neighboring generators or lines to trip offline, threaten power system stability. Controlled islanding mitigates cascade failures by deliberately removing a subset of transmission lines in order to partition the system into disjoint, internally stable islands. In this paper, we investigate algorithms for controlled islanding to ensure stability while minimizing power flow disruption and load-generator imbalance. We consider a scenario where there are heterogeneous loads with varying costs of load shedding and formulate a hybrid optimization problem of jointly selecting a set of transmission lines to remove (discrete variables) and how much load to shed at each bus (continuous variables). In order to solve this optimization problem with provable optimality bounds, we propose a new notion of hybrid submodularity. We develop a polynomial-time islanding algorithm that achieves a provable 1/2-optimality bound. We use IEEE 118-bus and ACTIVsg 500-bus case studies to demonstrate that our approach provides better islanding solutions compared to a Mixed-Integer Linear Program (MILP)-based approach.
Low Prevalence of Alterations in the Pancreatic Duct System in Patients with Primary Sclerosing Cholangitis (1996)

In PSC patients, the prevalence of chronic pancreatitis is low.
Detection of lead in paint samples synthesized locally using-laser-induced breakdown spectroscopy (2010)

A laser-induced breakdown spectroscopy (LIBS) setup was developed to detect lead and other toxic contaminants such as chromium in paint emulsion samples manufactured in Saudi Arabia. The lead concentration detected in these samples was in the 327.2-755.3 ppm range, which is much higher than the safe permissible limit set by Saudi regulatory agencies. Similarly, chromium concentration (98.1-149.5 ppm) was found in high concentrations as well. The results obtained with our LIBS setup are comparable with the sample analysis utilizing a standard technique such as ICP, and our LIBS results are comparable to ICP with in an accuracy limit of 2-4 %.
A fully-staring THz video camera for concealed object detection (Conference Presentation) (2020)

We present a fully-staring THz video camera prototype intended for security screening. The camera utilizes so-called kinetic inductance bolometers to detect THz radiation in the bandwidth of 0.3-1 THz. The imaging distance is 2.5 m with the field-of-view being 2 m × 1 m. The camera is equipped with a kilo-pixel detector array, large field-of-view optics, intermediate-scale cryogenics operating at 6 K, and low-noise electronics to read out the whole detector array. The imaging capabilities of the system are demonstrated through radiometric performance characterization and actual imaging experiments.
Efecto del exudado de Chaitophorus leucomelas sobre las propiedades hidráulicas del suelo (2013)

Soils may develop hydrophobic properties, causing either resistance to water infiltration or slowing the process. The aim of this study was to evaluate the effect of exudates of Chaitophorus leucomelas Koch, an aphid parasitic to Populus sp., on soil hydraulic properties and water repellency. Ch. leucomelas infested and non-infested sites were evaluated, using four randomly distributed replications for each case. The unsaturated hydraulic conductivity (K ns ) was measured using a tension disc infiltrometer at supply pressures of -10, -20, -40 and -60 mm, estimating saturated K (K 0 ). Hydrophobicity was determined in laboratory using the R index, based on water and ethanol sorptivity. Both sites showed a hydrophobic behavior when the soil was air dried, being higher in the Ch. leucomelas infested site, however, the hydrophobicity was lost upon wetting the soil. The infiltration of water decreased with the presence of the parasite, but the spatial variability prevented the occurrence of statistically significant differences between sites. The hydrophobicity and the K ns evaluated at -10 mm were exponentially fitted, which ensures that the behavior of K ns depends not only on the pore size distribution of the soil, but also on the proportion and distribution of the soil organic matter. Finally, K ns is presented as a tool to assess soil hydrophobicity at low pore water pressures to assess erosion in forest plantations.
Specific Elimination of Alloreactive T Lymphocytes Using Photodynamic Therapy Prevents GVHD and Enables Rapid Immune Reconstitution. (2004)

Abstract Graft-versus-host disease (GVHD) and impaired immune reconstitution are the primary obstacles limiting the efficacy of allogeneic stem cell transplantation (SCT). Graft-versus-host disease (GVHD) and impaired immune reconstitution are the primary obstacles limiting the efficacy of allogeneic stem cell transplantation (SCT). The purpose of this study was to determine whether selective depletion of donor alloantigen-specific T lymphocytes using photodynamic therapy (PDT) would prevent GVHD and enable immune reconstitution in the context of MHC-mismatched SCT. This question was addressed in an MHC-incompatible mouse model of GVHD. The donor (C57BL/6; H-2b) derived spleen cells were first activated against C3H/HeJ (H-2k) host spleen cells in a one-way mixed lymphocyte culture and then exposed to photodynamic treatment, using dibromorhodamine methyl ester (TH9402) as a photosensitizer. Activated T cells showed preferential retention of this photosensitizer compared to resting lymphocytes. In addition, in vitro experiments revealed that PDT eradicated a significantly higher proportion of activated than resting T cells. When lethally irradiated H-2k mice (C3H/HeJ and B10BR) were transplanted with C57BL/6 derived T cell-depleted bone marrow cells supplemented with C57BL/6 derived spleen cells activated with C3H/HeJ targets, they rapidly succumbed to acute GVHD (within 10–47 days). In contrast, both mouse strains receiving histoincompatible C57BL/6 T cells previously exposed to PDT after activation against C3H/HeJ survived until the end of the observation period (&gt;100 days)(p&lt;0.0001). Additionally, transplantation of treated T cells induced lethal GVHD in C57BL/6 histoincompatible strains of mice (third party), suggesting PDT specifically eradicated activated T cells while sparing most resting T lymphocytes. Analysis of immune recovery, evaluating T and B cell populations in thymus and spleen, activated T cells components (CD44, CD62L, CD69), proliferative responses (anti-CD3 and conA), and Vβ repertoire indicated that T and B cell reconstitution in MHC-mismatched mice transplanted with treated primed cells was similar to that of mice transplanted with treated or control autologous cells indicating that immune cells were preserved and functional. These results demonstrate that PDT can selectively eliminate alloreactive T cells and prevent the development of GVHD, while sparing T cells reactive against non-host antigens, thus offering protection against infection and disease relapse.