gebhart/patrepeval huggingface dataset:
Flameholding Analyses in Supersonic Flow (2004)

Flameholding in supersonic flow depends on the local conditions in the recirculation region and the mass transfer into and out o f this region. Large gradients in local gas composition and temperature exist in the recirculation region. Hence stability parameter correlations developed for premixed flames cannot be used to determine the blowout stability limits for non -premixed flames encountered in practical devices. In the present investigation, mixture samples at different locations in the recirculation region and the shear layer formed behind a rearward facing step have been extracted and analyzed by a mass spectrometer to determin e the local distribution of species concentration. Tests are performed with and without combustion. In combustion tests, the extracted samples are passed through a cooling jacket to quench the reactions and freeze the species composition coming out of the combustion chamber. The difference between the local mass fraction of injected gas within the recirculation region determined from mass spectroscopy and the global mass fraction based on the total mass of air and injected gas is thus identified. The inform ation will help formulate a stability parameter for non -premixed flames and for computational model validation.
Antimicrobial modification of polyester by admicellar polymerization (2008)

The N-halamine monomer 3-(4'-vinylbenzyl)-5,5-dimethylhydantoin (VBDMH) was synthesized and employed to form thin films on the surfaces of polyester fibers by surface polymerization with the aid of a cationic surfactant. The coated samples were characterized by FTIR and SEM. The thin film coatings could be rendered biocidal by exposure to dilute sodium hypochlorite. The antimicrobial polyesters were challenged with Staphylococcus aureus and Escherichia coli O157:H7. Complete inactivation of S. aureus and E. coli O157:H7 was observed within 10 and 30 min of contact time, respectively. The chlorine bonded to the coatings was very stable under standard washing tests and UVA irradiation tests, and much of the lost chlorine could be regenerated by rechlorination.
Fluorous Mixture Synthesis of Stereoisomer Libraries:  Total Syntheses of (+)-Murisolin and Fifteen Diastereoisomers (2003)

The synthesis of a stereoisomer library of 16 murisolins in individual pure form by fluorous mixture synthesis is reported. Four stereoisomeric precursors are tagged with different fluorous tags, and the resulting mixture is taken through the synthesis with four splits and late stage demixing and detagging to give all 16 products. These products exhibit only six different sets of NMR spectra, but all can be differentiated by chiral HPLC. The structure of murisolin is confirmed, but the structures of murisolin A and 16,19-cis-murisolin may never be known with certainty because insufficient data were collected on natural samples to differentiate each of them from one other isomer.
Run Time Approximation of Non-blocking Service Rates for Streaming\n Systems (2015)

Stream processing is a compute paradigm that promises safe and efficient\nparallelism. Modern big-data problems are often well suited for stream\nprocessing's throughput-oriented nature. Realization of efficient stream\nprocessing requires monitoring and optimization of multiple communications\nlinks. Most techniques to optimize these links use queueing network models or\nnetwork flow models, which require some idea of the actual execution rate of\neach independent compute kernel within the system. What we want to know is how\nfast can each kernel process data independent of other communicating kernels.\nThis is known as the "service rate" of the kernel within the queueing\nliterature. Current approaches to divining service rates are static. Modern\nworkloads, however, are often dynamic. Shared cloud systems also present\napplications with highly dynamic execution environments (multiple users,\nhardware migration, etc.). It is therefore desirable to continuously re-tune an\napplication during run time (online) in response to changing conditions. Our\napproach enables online service rate monitoring under most conditions,\nobviating the need for reliance on steady state predictions for what are\nprobably non-steady state phenomena. First, some of the difficulties associated\nwith online service rate determination are examined. Second, the algorithm to\napproximate the online non-blocking service rate is described. Lastly, the\nalgorithm is implemented within the open source RaftLib framework for\nvalidation using a simple microbenchmark as well as two full streaming\napplications.\n
Identification of Binding Peptides on Calcium Silicate Hydrate: A Novel View on Cement Additives (2014)

Phage display experiments on industrially important calcium silicate hydrates (C-S-H), the main hydration product of ordinary Portland cement, suggest fundamentally different specific binding motifs compared to hitherto existing commercial cement additives. According to that, a strong and specific adsorbing additive on C-S-H should have three features which are a negative charge, H-bond formers (especially amide functions) and a hydrophobic part.
Conformational characteristics of homo‐oligopeptides of O‐benzyl‐L‐tyrosine+ (1983)

Conformational studies of X[-L-Tyr(Bzl)-]n-series bound to polyethyleneglycol (X = H2, Nps; n = 3-8) in the solid state and in solvents of different polarities and capabilities of forming hydrogen bonds are reported. By using i.r. absorption, the occurrence of the beta-structure in the higher oligomers in the solid state was established. By means of i.r. absorption and CD the onset of that ordered conformation in solution was assessed as a function of chain length. The effects induced by the presence of the N-protecting group and added base, and by changing the nature of solvent on the conformational preferences of the [-L-Tyr(Bzl)-]n homo-peptides were also examined. The 2-nitrophenylsulphenyl chromophoric derivative of the alpha-amino group is proposed as a circular dichroism sensor for beta-structure in peptides.
Immunophenotypic Analysis of HL-60 Cells during Basophilic Differentiation (1996)

Differentiation along specific myeloid lineages may be accompanied by characteristic cell surface marker changes. We have examined leukemic HL-60 cell changes under conditions which induce basophilic differentiation. An increased surface expression of CD35, CD11b, and decreased expression of CD15 was found by flow cytometry during the 5-day induction period. Further investigation revealed two cell populations after 5 days in vitro: (i) a CD35-positive population (61% of cells present) containing a significant number of CD15-negative cells, and (ii) a CD15-positive/CD35-negative population. The CD35-positive subset appears to account for the majority of the basophilic cells induced under these conditions, as measured by histamine content and metachromatic staining. In addition, this subset contains a small number of early monocytic cells (CD14 and CD23 positive). The expression of CD11b is variably found on the CD15-positive/ CD35-negative subset of induced cells. These results suggest that CD35 and CD15 surface immunophenotyping can be used to map steps involved in myeloid development. A role for CD35 and CD15 in early basophil differentiation is proposed.
The Reactivity and Structural Dynamics of Supported Metal Nanoclusters Using Electron Microscopy, in-situ X-Ray Spectroscopy, Electronic Structure Theories, and Molecular Dynamics Simulations (2022)

This research will provide new methods to determine the structures and compositions of heterogeneous catalysts as they exist in reaction conditions. The new tools will make it possible to understand how extremely small material structures—ones in a size range spanning from single atoms to larger polyatomic clusters—make it possible to carry out highly selective chemical transformations required to synthesize useful materials as well as for efficient energy production and utilization. The tools will make it possible to see how the atomic structures of catalytic materials evolve over time under the conditions of their use, and in this way provide understandings to guide the design of new energy-efficient catalysts. The work will make it possible to answer long standing questions that include the following. How does catalyst structure help guide molecules along specific reaction pathways? What are the important intermediates involved in these transformations? How do the structures and reactivity of catalytic materials, as well as the chemistry of their interfaces, vary with reaction conditions? Is it possible to develop new catalytic materials using new knowledge of the active structures and reaction mechanisms? The work will provide heretofore unavailable experimental tools that can be applied in advanced programs of research addressing such questions.
Specificity of signal molecules in the activation of Agrobacterium virulence gene expression (1989)

The activation of the Agrobacterium virulence system is known to be induced by certain phenolic compounds. We have tested the vir-inducing ability of fifty compounds, by using a virB-lacZ gene fusion, and analysed the relationship between structure and activity of these compounds. In this way we have identified several new vir-inducers: coniferylalcohol, 3,5-dimethoxy-4-hydroxybenzene, homovanillic acid, ferulic acid, 3-ethoxy-4-hydroxybenzaldehyde and guaiacol, all of which are compounds with strong or moderate activity and four compounds with weak vir-inducing activity. In view of the specificity of vir-inducers, our data extended observations of others and enabled us to define the specific structural features of a vir-inducer molecule. In addition we show here that induction of the octopine Ti vir-genes is (i) optimal at 29 degrees C and totally abolished at 37 degrees C, and (ii) strongly inhibited at low concentrations of sodium chloride. The implications for plant transformation are discussed.
Les anti-TNF-α pour le traitement des uvéites non infectieuses (2020)

Non-infectious uveitis is a heterogenous group of potentially blinding ocular autoimmune diseases that may represent a manifestation of a systemic condition or may affect the eyes only. A systemically administered anti-TNF has recently been approved for the treatment of non-infectious uveitis, broadening the therapeutic arsenal available to control intraocular inflammation and reduce uveitis complications that can lead to vision loss. When uveitis affects only the eyes, a local anti-TNF-α administration strategy could optimize the ocular therapeutic effect and reduce undesirable systemic side-effects. A new ocular method of non-viral gene therapy, currently in development, may broaden the indications for ocular anti-TNF-α agents, not only for uveitis but also for other diseases in which TNF-α-mediated neuro-inflammation has been demonstrated.
Letters (2010)

Institute Of Clinical Neuroscience; Norwegian University of Science and Technology (NTNU); Olav Kyrresgt; Trondheim, Norway (Leivseth) Prof Dr rer nat, Klinik für Technische Orthopädie und Rehabilitation; Universitätsklinikum Münster; Domagkstrasse, Münster, Germany (Brinckmann) The device(s)/drug(s) is/are FDA-approved or approved by corresponding national agency for this indication. No funds were received in support of this work. No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript.
Randomized Maintenance Therapy with Azacitidine (Vidaza) in Older Patients (>= 60 years of age) with Acute Myeloid Leukemia (AML) and Refractory Anemia with Excess of Blasts (RAEB, RAEB-t). Results of the HOVON97 Phase III Randomized Multicentre Study (EudraCT 2008-001290-15) (2017)

Purpose: The prevention of relapse is the major therapeutic challenge in older patients with acute myeloid leukemia (AML) who have obtained a complete remission on intensive chemotherapy. There is no established post-remission treatment for prevention of relapse in this setting, except allo HSCT. This randomized phase III study (HOVON97) in older patients (≥ 60 years) with AML or MDS-RAEB in CR/CRi after at least 2 cycles of intensive chemotherapy assessed the value of azacitidine as post remission therapy (in comparison to observation) with respect to the disease free survival (primary endpoint) and overall survival (secondary endpoint). Patients and methods: In total 117 patients were randomly 1:1 assigned to either observation (control group ) or azacitidine maintenance (aza group), 50 mg/m2, s.c., day 1-5, q 4 weeks, until relapse for a maximum of 12 cycles. The study was powered to detect improvement in disease free survival (DFS) after 1 year from 40% to 60% (power 80%, two-sided test at 5% significance). The current pre-final evaluation after study closure is based on the first 109 patients with at least one year follow-up. The 2 arms (56 control patients vs 53 aza maintenance patients) were comparable with regard to age (60-81 years, median 69 years), performance status, peripheral blood counts and cytogenetics. Although all patients had Results: A total of 52 patients received at least 1 cycle of aza. Subsequently, 44, 40, 34 and 32 patients received at least 3, 6, 9 and 12 cycles respectively. The maintenance treatment with aza was feasible, as, during the first 4 cycles, most treatments could be given according to schedule (87% Conclusion: Post-remission treatment with aza in older AML patients in CR/CRi after at least 2 cycles of intensive chemotherapy significantly improves DFS (p=0.005). When patients who received an allo HSCT were censored at time of transplant, the difference in OS between both arms was also significantly different (p=0.04), in favor of aza maintenance treatment Disclosures Huls: Celgene: Consultancy; JJ Gadeta (www.gadeta.nl): Consultancy, Equity Ownership, Patents & Royalties: on gdT cells and receptors and isolation strategies , Research Funding. Ossenkoppele: JJ Celgene: Honoraria, Research Funding; Roche: Honoraria; Karyopharm: Consultancy, Research Funding; Novartis: Research Funding.
Silicon integrated nanophotonics for on-chip optical interconnects (2008)

As multi-core microprocessor architectures continue to evolve as a promising platform for high-performance computing, an additional set of challenges emerges for the global interconnects between distant cores. In particular, the limited throughput and large power consumption of electrical copper interconnects are becoming dominant factors limiting the continued scaling of processor performance. One promising solution is to complement conventional global interconnects with a CMOS-compatible intra-chip optical network, based on silicon-on-insulator (SOI) photonic integrated circuits. We will review recent results on silicon nanophotonic circuits based on SOI photonic wires and photonic crystals. Silicon nanophotonic devices have immense capacity for low-loss, high-bandwidth data transmission, and can confine light within sub-micron dimensions, enabling the design of ultra-compact optical devices for all necessary functions within such optical networks. While the bandwidth and power consumption advantages of SOI optical interconnects are potentially immense, ensuring the performance of chip-scale networks places stringent requirements upon the control of the manufacturing process, and its influence upon the operation of individual optical components. We will present recent work on the design, fabrication, and demonstration of various passive and electrooptic devices required for high speed optical interconnect applications, including high-order WDM optical filters, modulators, and switches.
Optimized conditions for diluting and reusing a fluorescent protein gel stain (2004)

This study elucidates the optimum conditions at the minimum cost for using SYPRO Ruby protein gel stain. It deals with the effects of gel fixation and staining times, as well as dilution and reuse of SYPRO Ruby protein gel stain in one-dimensional (1-D) gels. Signal strength and dynamic range were highest in gels that were fixed thoroughly before staining, followed by overnight staining. Using the optimized protocol, dilution or reuse of the stain reduces the dynamic range and signal intensity. Sensitivity remains high if the stain is reused up to two times, but signal intensity is reduced up to 2.5-fold in twice used stain. Sensitivity also remains high if the stain is diluted 1:2 in water, but signal intensity is reduced up to 6-fold. Of the two options, reuse or dilution, reuse better retains signal intensity and dynamic range.
Crystallization in the Thin and Ultrathin Films of Poly(ethylene-vinyl acetate) and Linear Low-Density Polyethylene (2005)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionCrystallization in the Thin and Ultrathin Films of Poly(ethylene-vinyl acetate) and Linear Low-Density PolyethyleneS. Ge, M. Rafailovich*, J. Sokolov, Y. Zou, H. Ade, J. Lüning, A. Lustiger, and G. MaromCite this: Macromolecules 2005, 38, 5, 2022Publication Date (Web):February 8, 2005Publication History Published online8 February 2005Published inissue 1 March 2005https://pubs.acs.org/doi/10.1021/ma0501601https://doi.org/10.1021/ma0501601correctionACS PublicationsCopyright © 2005 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views330Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (43 KB) Get e-Alertsclose Get e-Alerts
Pharmacologic and Biochemical Profiles of New Venous Antithrombotic β-D-Xyloside Derivatives: Potential Antiathero/thrombotic Drugs (1996)

Following a screening program for orally active antithrombotic drugs, it was found that a series of thioxyloside compounds presented with good venous antithrombotic properties. Of more than 500 compounds, LF 09-0055, LF 04-0212, and LF 05-0030 were the most active at inhibiting venous thrombus formation in the rat and rabbit Wessler model after intravenous and oral dosing. LF 05-0030 showed the greatest activity with an ED80 value of 6 mg/kg on oral administration in rats. This activity was maintained in several different models of venous thrombosis and shown to be devoid of anticoagulant effects or hemorrhage. Kinetic studies have demonstrated that maximal levels of activity, following either intravenous or oral dosing, occurred between 2 and 4 hours after administration. This may reflect the type of mechanism involved, since it has been well documented in the literature that xylosides are capable of initiating glycosaminoglycan (GAG) synthesis. Moreover, in vitro galactosyltransferase 1 (the second enzyme involved in GAG polymerization) enzymic assays showed that these thioxyloside derivatives were good acceptors for galactose transfer and therefore at initiating GAG formation. Further in vivo experimentation demonstrated that after treatment by these molecules an important elevation in circulating GAG occurred, with LF 05-0030 presenting the greatest activity, being five times higher than control levels. In addition it was found that dermatan sulfate levels, expressed as antithrombin activity by heparin cofactor II, were significantly increased over control values. As such, this dermatan sulfate moiety is believed to support the antithrombotic activity observed. Studies are underway to investigate the activity of these interesting molecules in atherosclerosis and other vessel wall diseases.
rs4919510 in hsa-mir-608 Is Associated with Outcome but Not Risk of Colorectal Cancer (2012)

These results suggest that rs4910510 may be associated with colorectal cancer survival in a manner that is dependent on race.
Automated Thermal Drift Compensation in WDM-based Silicon Photonic Multi-Socket Interconnect Systems (2020)

We present an on-chip AWGR-based interconnect system with automated thermal drift compensation along cascaded resonant structures in a dual-socket layout. Error-free operation in a 30 Gb/s data-routing scenario within a 12C temperature range is demonstrated.
Infrared fibers (2015)

Infrared (IR) fibers offer a versatile approach to guiding and manipulating light in the IR spectrum, which is becoming increasingly more prominent in a variety of scientific disciplines and technological applications. Despite well-established efforts on the fabrication of IR fibers in past decades, a number of remarkable breakthroughs have recently rejuvenated the field—just as related areas in IR optical technology are reaching maturation. In this review, we describe both the history and recent developments in the design and fabrication of IR fibers, including IR glass and single-crystal fibers, multimaterial fibers, and fibers that exploit the transparency window of traditional crystalline semiconductors. This interdisciplinary review will be of interest to researchers in optics and photonics, materials science, and electrical engineering.
FoxO1 Haploinsufficiency Protects Against High-Fat Diet–Induced Insulin Resistance With Enhanced Peroxisome Proliferator–Activated Receptor γ Activation in Adipose Tissue (2009)

These findings indicate that FoxO1 proteins negatively regulate insulin action and that their effect may be explained, at least in part, by inhibition of PPARgamma function.
Experimental Investigation of Lasing Modes in Double-Lattice Photonic-Crystal Resonators and Introduction of In-Plane Heterostructures (2019)

Photonic-crystal surface-emitting lasers (PCSELs) are attractive for a wide range of applications such as material processing and remote sensing owing to their advantage of broad-area coherent lasing supported by a 2-D photonic crystal. Recently, we proposed double-lattice photonic-crystal resonators and achieved 10-W-class high-power and high-beam-quality (namely, high-brightness) operation. To further increase the brightness, it is important to understand the lasing mode behavior of PCSELs in detail. In this article, we experimentally investigate the change in the lasing mode depending on the current injection levels and compare the results with a theoretical analysis that accounts for the change in refractive index and gain distributions due to the current injection. We observed a transition from single-mode lasing to two-mode lasing at high injection currents. We develop a technique for resolving the near-field profiles of individual lasing modes and show that these profiles coincide with theoretical predictions. A comparison of experimental and theoretical results reveals that high-order modes appear due to a bandgap confinement effect induced by a change in the refractive index in the carrier injection area. To effectively remove this confinement effect and suppress the oscillation of high-order modes, we incorporate an in-plane heterostructure into the PCSEL.