gebhart/patrepeval huggingface dataset:
Crystal Structure of MCM-22 (MWW) and Its Delaminated Zeolite ITQ-2 from High-Resolution Powder X-Ray Diffraction Data: An Analysis Using Rietveld Technique and Atomic Pair Distribution Function (2009)

The three-dimensional structure of crystalline, calcined pure siliceous MCM-22 (which has a chemical formula of Si72O144) and its delaminated derivative, ITQ-2 (which has a chemical formula of Si144O288), also in its calcined form, have been studied using synchrotron radiation-based powder diffraction experiments employing full pattern Rietveld analysis for structure elucidation. Because of the limited structural coherence in ITQ-2, conventional analysis of the X-ray diffraction experiments using Bragg peaks only is not suitable. Instead, we applied the pair distribution function (PDF) technique to study the structure of ITQ-2, in particular, the termination of the layer slab. Despite of the structural complexity of the zeolite materials, excellent confirmation of the crystal structure based on Rietveld analysis (RBragg = 12.6%) was obtained with PDF analysis (Rw = 18.3%) for the calcined siliceous MCM-22. Based on results of the crystalline compound, we only succeeded to refine the diffraction data set of the delaminated material applying PDF analysis.
Application of Boolean unification to combinational logic synthesis (2002)

The authors present various applications of Boolean unification to combinational logic synthesis. Three topics of combinational logic synthesis are discussed: redesign, multilevel logic minimization, and minimization of Boolean relations. All of these problems can be uniformly formalized as Boolean unification problems. Experimental results are also reported.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Current-voltage characteristic hysteresis dependence on power supply regime for large area field emitters (2016)

We investigated the hysteresis phenomenon in current-voltage characteristics of multipoint emitters based on nanocomposites with carbon nanotubes and graphene. The conditions under which the change in shape of the hysteresis from “direct” to “reverse” or vice versa occurs were found. Mass-spectrometer data allowed to associate hysteresis with adsorbed particles a source of which is the anode.
Structural investigation of Cetrorelix, a new potent and long‐acting LH‐RH antagonist (1994)

The new decapeptide SB-75 (INN: Cetrorelix) has been characterized as a potent antagonist of luteinizing-hormone releasing hormone (LH-RH). Such derivatives are of great medicinal interest owing to their potential application in areas such as hormone-dependent tumors, uterine fibroids, and in diseases and conditions which result from inappropriate hormone levels or which can be treated by suppression of estrogens. SB-75 is the subject of intensive ongoing clinical evaluation and is an accepted standard for the design of new LH-RH antagonists. We characterized SB-75 by means of modern MS and NMR techniques to demonstrate the significance of both sequencing methods on a complicated unnatural decapeptide. Our structural elucidations with nuclear Overhauser (NOE) experiments revealed clear evidence for a highly flexible molecule with no single predominant conformation even in sodium dodecyl sulfate (SDS) mimicking a cellular membrane.
Near-Oracle Performance of Basis Pursuit under Random Noise (2009)

We consider the problem of estimating a deterministic sparse vector x from underdetermined measurements Ax+w, where w represents white Gaussian noise and A is a given deterministic dictionary. We analyze the performance of three sparse estimation algorithms: basis pursuit denoising (BPDN), orthogonal matching pursuit (OMP), and thresholding. These algorithms are shown to achieve near-oracle performance with high probability, assuming that x is sufficiently sparse. Our results are non-asymptotic and are based only on the coherence of A, so that they are applicable to arbitrary dictionaries. Differences in the precise conditions required for the performance guarantees of each algorithm are manifested in the observed performance at high and low signal-to-noise ratios. This provides insight on the advantages and drawbacks of convex relaxation techniques such as BPDN as opposed to greedy approaches such as OMP and thresholding.
Reactions of N-Heterocyclic Carbene Boranes with 5-Diazo-2,2-dimethyl-1,3-dioxane-4,6-dione: Synthesis of Mono- and Bis-hydrazonyl NHC-Boranes (2018)

N-Heterocyclic carbene boranes (NHC-boranes) react with 5-diazo-2,2-dimethyl-1,3-dioxane-4,6-dione at 40 °C in dichloromethane to provide NHC-boryl hydrazone derivatives of 2,2-dimethyl-1,3-dioxane-4,6-dione. These hydrazones disproportionate to bis-hydrazones on treatment with diiodine in dichloromethane at room temperature. The mono- and bis-hydrazones are yellow solids that are stable to chromatography and storage.
Immunological Predictors of Nonresponse to Directly Acting Antiviral Therapy in Patients With Chronic Hepatitis C and Decompensated Cirrhosis (2017)

Nonresponders to DAAs displayed a different NK phenotype and CXCL-10 profile to responders. Nonresponders did not have poorer adherence or baseline virological resistance, and this shows that immunological parameters are associated with treatment response to interferon-free treatment for HCV in individuals with decompensated cirrhosis.
Abdominal CT: Comparison of Adaptive Statistical Iterative and Filtered Back Projection Reconstruction Techniques (2010)

ASIR lowers noise and improves diagnostic confidence in and conspicuity of subtle abdominal lesions at 8.4 mGy when images are reconstructed with 30% ASIR blending and at 4.2 mGy in patients weighing 90 kg or less when images are reconstructed with 50% or 70% ASIR blending.
Low-Cost Median Barrier Gate (2012)

Median barriers are commonly used to separate opposing lanes of traffic on divided highways and to separate managed lanes from general purpose lanes. Concrete median barriers (CMBs) are often preferred on urban freeways with narrow medians because of their minimal deflection and low maintenance. However, long, continuous runs of CMBs limit access of emergency and maintenance vehicles to the other side of a roadway or a managed lane. Implementation of crashworthy median barrier gates at these locations can maintain the desired level of median protection for motorists while offering improved cross-median access for emergency and maintenance vehicles. A new median barrier gate was developed and crash tested. The gate spans a 30-ft opening in a CMB and consists of two vertically stacked 12- x 12- x ¼-in. steel tubes connected to steel end brackets with 2¼-in. diameter steel pins. The gate is economical to fabricate and install. It can be manually operated by a single person and is designed to accommodate reversible traffic flow on both sides of the median and be operable in both directions on each end. The median barrier gate satisfies the criteria for impact performance of Test Level 3 of the Manual for Assessing Safety Hardware and is considered suitable for implementation on divided highways at locations where cross-median access is desired.
Catheter Treatment of Ventricular Tachycardia: A Reference-Less Pace-Mapping Method to Identify Ablation Targets (2019)

The reference-less method might either be used in complement of the conventional method or to treat patients in whom VT cannot be induced during the intervention.
Achieving scalable capacity in wireless networks with adaptive power control (2005)

The seminar work of Gupta and Kumar showed that multi-hop wireless networks with capacity scalable with the number of nodes, n, are achievable in theory. The transport capacity scales as /spl Theta/(/spl radic/n), while the capacity scales as /spl Theta/(n). A subsequent study, on the other hand, showed that the capacity of IEEE 802.11 networks does not scale with n due to its carrier-sensing mechanism. This prior work, however, has not considered the use of power control. The main contributions of this paper are three-folds: 1) we provide an analytical framework for deriving the design requirements of adaptive power control strategies; 2) we demonstrate that 802.11 networks are scalable with power control; 3) however, an enhanced MAC protocol called selective disregard of NAVs (SDN) can achieve substantially higher capacity with an adaptive power control scheme; in particular, adaptive power control allows SDN to achieve capacity within 75% of the theoretical optimal capacity of infrastructure-mode wireless networks. A reason why adaptive power control works well is that it takes into consideration the fundamental mutual-interference relationships between links in the vicinity of each other, and adjust their relative transmit powers to reduce these interferences to a large extent that is possible theoretically.
Transient DNA Strand Breaks During Mouse and Human Spermiogenesis:New Insights in Stage Specificity and Link to Chromatin Remodeling1 (2004)

In the course of mammalian spermiogenesis, a unique chromatin remodeling process takes place within elongating and condensing spermatid nuclei. The histone-to-protamine exchange results in efficient packaging and increased stability of the paternal genome. Although not fully understood, this change in chromatin architecture must require a global but transient appearance of endogenous DNA strand breaks because most of the DNA supercoiling is eliminated in the mature sperm. To establish the extent of DNA strand breakage and the stage specificity at which these breaks are created and repaired, we performed a sensitive terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL) assay to detect in situ DNA strand breaks on both mice and human testis cross sections. In the mouse, we established that DNA strand breaks are indeed detected in the whole population of elongating spermatids between stages IX and XI of the seminiferous epithelium cycle perfectly coincident with the chromatin remodeling as revealed by histone H4 hyperacetylation. Similarly, TUNEL analyses performed on human testis sections revealed an elevated and global increase in the levels of DNA strand breaks present in nuclei of round-shaped spermatids also coincident with chromatin remodeling. The demonstration of the global character of the transient DNA strand breaks in mammalian spermiogenesis suggests that deleterious consequences on genetic integrity of the male gamete may arise from any disturbance in the process. In addition, this investigation may shed some light on the origin of the low success rate that has been encountered so far with intracytoplasmic injection procedures making use of round spermatids in humans.
Spinal cord stimulation suppresses bradycardias and atrial tachyarrhythmias induced by mediastinal nerve stimulation in dogs (2006)

Spinal cord stimulation (SCS) applied to the dorsal aspect of the cranial thoracic cord imparts cardioprotection under conditions of neuronally dependent cardiac stress. This study investigated whether neuronally induced atrial arrhythmias can be modulated by SCS. In 16 anesthetized dogs with intact stellate ganglia and in five with bilateral stellectomy, trains of five electrical stimuli were delivered during the atrial refractory period to right- or left-sided mediastinal nerves for up to 20 s before and after SCS (20 min). Recordings were obtained from 191 biatrial epicardial sites. Before SCS (11 animals), mediastinal nerve stimulation initiated bradycardia alone (12 nerve sites), bradycardia followed by tachyarrhythmia/fibrillation (50 sites), as well as tachyarrhythmia/fibrillation without a preceding bradycardia (21 sites). After SCS, the number of responsive sites inducing bradycardia was reduced by 25% (62 to 47 sites), and the cycle length prolongation in residual bradycardias was reduced. The number of responsive sites inducing tachyarrhythmia was reduced by 60% (71 to 29 sites). Once elicited, residual tachyarrhythmias arose from similar epicardial foci, displaying similar dynamics (cycle length) as in control states. In the absence of SCS, bradycardias and tachyarrhythmias induced by repeat nerve stimulation were reproducible (five additional animals). After bilateral stellectomy, SCS no longer influenced neuronal induction of bradycardia and atrial tachyarrhythmias. These data indicate that SCS obtunds the induction of atrial arrhythmias resulting from excessive activation of intrinsic cardiac neurons and that such protective effects depend on the integrity of nerves coursing via the subclavian ansae and stellate ganglia.
Grain growth and characteristics of chlorine doped thick polycrystalline CdZnTe films (2012)

Chlorine (CI)-doped polycrystalline CdZnTe is expected to be used as photoconductor material for Flat Panel Xray detectors (FPDs) due to its high detection efficiency and environmental resistance. However, polycrystalline film causes great variability among pixels in the X-ray image of FPDs. To reduce the variability among pixels, chlorine doping methods and their effects were investigated. By combining the two methods, the addition of CdCl <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> to the source and the introduction of vapor chloroform during deposition, we were able to reduce the variability among pixels.
Table S5 from Theranostic Radiolabeled Anti-CD20 sdAb for Targeted Radionuclide Therapy of Non-Hodgkin Lymphoma (2023)

&lt;p&gt;Ex vivo biodistribution of 68Ga-NOTA-sdAb 9077, 9079 and non-target control sdAb (68Ga-NOTA-ctrl sdAb) at 1.5 h p.i., in hCD20 B16 tumor mouse model. Results are presented as mean % IA/g {plus minus} SD (n = 3 per sdAb).&lt;/p&gt;
Phase I/II study of adoptive T-cell therapy following in vivo priming with a HER2/neu vaccine in patients with advanced-stage HER2+ breast cancer. (2014)

615 Background: We have reported that infusion of ex vivo expanded T cells derived from previously HER2-vaccine-primed PBMC is safe and able to mediate an anti-tumor response in patients with HER2+ breast cancer (Disis 2013). In this study, we evaluated the safety and clinical efficacy of infusion of HER2 specific T cells after rapid HER2 vaccinations in patients with advanced stage HER2+ breast cancer. Methods: 19patients were vaccinated three times weekly with a HER2 peptide based vaccine. HER2 specific T-cells were expanded 2 weeks after 3rd vaccine. The patients received 2-3 escalating doses of T-cells given at 7-10 day intervals. Cyclophosphamide was administrated before the first dose of T- cells. One patient underwent indium-111 labeling of T-cells for SPECT/CT scanning. Results: All patients received at least two doses of HER2 specific expanded T-cells. The infused T-cell products were >98% of CD3+ with an average of 43% CD4+ and 54% CD8+ T-cells. The total number of T-cells infused was 0.3x109 – 57.1x109 (median 17.5x109). Subjects tolerated the infusions well with 95% of adverse events of grade 1 or 2. There were no complete or partial responses. 59% had stable disease (SD) 1-3 months after infusion and 41% of the patients demonstrated progressive disease (PD). The frequencies of HER2 specific T-cells in the infused products were significantly higher in patients with SD than that in PD (p=0.039). The percentage of CD4+ cells in products was positively correlated with HER2 specific T-cells (p=0.017). HER2 immunity was generated in vivo and augmented in magnitude after infusion and was maintained 3-9 months post infusion in the majority of patients. SPECT/CT of In-111 labeled T-cells demonstrated cell trafficking to all sites of metastatic disease. Conclusions: Adoptive transfer of HER2 specific T-cells generated from PBMC after rapid immunization is feasible and safe. Clinical outcome is associated with the frequency of HER2 specific CD4 T-cells present in the infusion product. Clinical trial information: NCT00791037.
Data from p53MVA Therapy in Patients with Refractory Gastrointestinal Malignancies Elevates p53-Specific CD8<sup>+</sup> T-cell Responses (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; To conduct a phase I trial of a modified vaccinia Ankara (MVA) vaccine delivering wild-type human p53 (p53MVA) in patients with refractory gastrointestinal cancers.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Three patients were vaccinated with 1.0 × 10&lt;sup&gt;8&lt;/sup&gt; plaque-forming unit (pfu) p53MVA followed by nine patients at 5.6 × 10&lt;sup&gt;8&lt;/sup&gt; pfu. Toxicity was classified using the NCI Common Toxicity Criteria and clinical responses were assessed by CT scan. Peripheral blood samples were collected pre- and post-immunization for immunophenotyping, monitoring of p53MVA-induced immune response, and examination of PD1 checkpoint inhibition &lt;i&gt;in vitro&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; p53MVA immunization was well tolerated at both doses, with no adverse events above grade 2. CD4&lt;sup&gt;+&lt;/sup&gt; and CD8&lt;sup&gt;+&lt;/sup&gt; T cells showing enhanced recognition of a p53 overlapping peptide library were detectable after the first immunization, particularly in the CD8&lt;sup&gt;+&lt;/sup&gt; T-cell compartment (&lt;i&gt;P&lt;/i&gt; = 0.03). However, in most patients, this did not expand further with the second and third immunization. The frequency of PD1&lt;sup&gt;+&lt;/sup&gt; T cells detectable in patients' peripheral blood mononuclear cells (PBMC) was significantly higher than in healthy controls. Furthermore, the frequency of PD1&lt;sup&gt;+&lt;/sup&gt; CD8&lt;sup&gt;+&lt;/sup&gt; T cells showed an inverse correlation with the peak CD8&lt;sup&gt;+&lt;/sup&gt; p53 response (&lt;i&gt;P&lt;/i&gt; = 0.02) and antibody blockade of PD1 &lt;i&gt;in vitro&lt;/i&gt; increased the p53 immune responses detected after the second or third immunizations. Induction of strong T-cell and antibody responses to the MVA backbone were also apparent.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusion:&lt;/b&gt; p53MVA was well tolerated and induced robust CD8&lt;sup&gt;+&lt;/sup&gt; T-cell responses. Combination of p53MVA with immune checkpoint inhibition could help sustain immune responses and lead to enhanced clinical benefit. &lt;i&gt;Clin Cancer Res; 20(17); 4459–70. ©2014 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Coordinated Regulation of Replication Protein A Activities by Its Subunits p14 and p32 (2004)

The heterotrimeric replication protein A (RPA) has multiple essential activities in eukaryotic DNA metabolism and in signaling pathways. Despite extensive analyses, the functions of the smallest RPA subunit p14 are still unknown. To solve this issue we produced and characterized a dimeric RPA complex lacking p14, RPADeltap14, consisting of p70 and p32. RPADeltap14 was able to bind single-stranded DNA, but its binding mode and affinity differed from those of the heterotrimeric complex. Moreover, in the RPADeltap14 complex p32 only minimally recognized the 3'-end of a primer in a primer-template junction. Partial proteolytic digests revealed that p14 and p32 together stabilize the C terminus of p70 against degradation. Although RPADeltap14 efficiently supported bidirectional unwinding of double-stranded DNA and interacted with both the simian virus 40 (SV40) large T antigen and cellular DNA polymerase alpha-primase, it did not support cell-free SV40 DNA replication. This inability manifested itself in a failure to support both the primer synthesis and primer elongation reactions. These data reveal that efficient binding and correct positioning of the RPA complex on single-stranded DNA requires all three subunits to support DNA replication.
Swept source optical coherence microscopy using a 1310 nm VCSEL light source (2013)

We demonstrate high speed, swept source optical coherence microscopy (OCM) using a MEMS tunable vertical cavity surface-emitting laser (VCSEL) light source. The light source had a sweep rate of 280 kHz, providing a bidirectional axial scan rate of 560 kHz. The sweep bandwidth was 117 nm centered at 1310 nm, corresponding to an axial resolution of 13.1 µm in air, corresponding to 8.1 µm (9.6 µm spectrally shaped) in tissue. Dispersion mismatch from different objectives was compensated numerically, enabling magnification and field of view to be easily changed. OCM images were acquired with transverse resolutions between 0.86 µm - 3.42 µm using interchangeable 40X, 20X and 10X objectives with ~600 µm x 600 µm, ~1 mm x 1 mm and ~2 mm x 2 mm field-of-view (FOV), respectively. Parasitic variations in path length with beam scanning were corrected numerically. These features enable swept source OCM to be integrated with a wide range of existing scanning microscopes. Large FOV mosaics were generated by serially acquiring adjacent overlapping microscopic fields and combining them in post-processing. Fresh human colon, thyroid and kidney specimens were imaged ex vivo and compared to matching histology sections, demonstrating the ability of OCM to image tissue specimens.
Antiprotozoal Activity of the Cyclopalladated Complexes AgainstLeishmania amazonensisandTrypanosoma cruzi (2015)

The present study describes the antiprotozoal activities of four cyclopalladated compounds, [Pd(dmba)(-Cl)] 2 , [Pd(dmba)(NCO)(isn)], [Pd(dmba)(N 3 )(isn)] and [Pd(dmba)(-NCO)] 2 , (dmba: N,N'-dimethylbenzylamine and isn: isonicotinamide), against the diseases leishmaniasis (Leishmania amazonensis and Leishmania infantum), Chagas disease (Trypanosoma cruzi) and human African trypanosomiasis (Trypanosoma brucei). [Pd(dmba)(-NCO)] 2 exhibited good leishmanicidal and trypanocidal activities against L. amazonensis and T. cruzi intracellular amastigote forms, with a 50% inhibitory concentration (IC 50 ) value of less than 9 M and selectivity indexes of 14.47 and 28.42, respectively. Stability essays were conducted in phosphate buffer saline (PBS) pH 7.0 and showed that [Pd(dmba)(-NCO)] 2 is the most stable molecule. These findings indicate that this compound presented higher selectivity for these parasites than the other tested compounds. The data presented here suggest that this compound should be considered in the development of new and more potent drugs for the treatment of leishmaniasis and Chagas disease.
Observation of a 390-nm Emission Band Associated with Framework Ti in Mesoporous Titanosilicates (2000)

A mesoporous titanosilicate lacking titanol groups has been prepared by exhaustive OH silylation and characterized by 29Si NMR, by XANES, and by its catalytic activity for cyclohexene epoxidation. Through a comparison of the luminescence of this silylated Ti−MCM-41 titanosilicate with that of the original Ti−MCM-41 before and after calcination, firm experimental support that an emission band appearing at λmax = 390 nm is due to the tetrapodal framework Ti(OSi⋮)4 is provided.
Porous silicon photoluminescence versus HF etching: No correlation with surface hydrogen species (1993)

The photoluminescence (PL) and infrared absorbance of electrochemically anodized, initially nonphotoluminescent, porous silicon samples were examined as a function of hydrofluoric acid (HF) etching time. Transmission Fourier transform infrared spectroscopy measurements revealed that the infrared absorbance from silicon hydrogen surface species immediately decreased with HF etching. In contrast, the PL did not appear until after HF etching times of 20–80 min, depending on initial sample porosity. Subsequently, the PL intensity increased, reached a maximum, and then progressively decreased versus HF etching time. These HF etching results demonstrate that there is no direct correlation between the PL and the silicon hydrogen surface species.
ChemInform Abstract: Synthesis of Multi‐Substituted Dibenzo[b,d]furan. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Table 3 from Identification of Epigenetically Silenced Genes in Tumor Endothelial Cells (2023)

Supplementary Table 3 from Identification of Epigenetically Silenced Genes in Tumor Endothelial Cells