gebhart/patrepeval huggingface dataset:
Modulation of virus-induced innate immunity and type 1 diabetes by IL-1 blockade (2013)

We used the LEW1.WR1 model of Kilham rat virus (KRV)-induced type 1 diabetes (T1D) to test the hypothesis that blocking IL-1 pathways early in the course of the disease can modulate virus-induced innate immunity and prevent disease progression. Administering KRV plus IL-1 receptor antagonist (Anakinra) for 14 d prevented insulitis and T1D. Anakinra reversed the KRV-induced systemic inflammation evidenced by the accumulation of T cells in the spleen and pancreatic lymph nodes on d 5 post-infection. Blocking IL-1 modulated the level of IRF-7 and IL-6 gene expression in the spleen and the p40 subunit of IL-12 and IL-23 in the serum. Anakinra did not interfere with the ability of LEW1.WR1 rats to clear the virus from the spleen, pancreatic lymph nodes or serum. Consistent with these data, normal levels of KRV-specific adaptive immune responses were detected in in the spleen and peripheral blood of the treated animals. Finally, blocking IL-1 pathways reversed the KRV-induced modulation of gut bacterial communities. The data may imply that IL-1 pathways are directly linked with early mechanisms whereby KRV infection leads to islet destruction, raising the hypothesis that blocking IL-1 pathways early in the course of the disease could be a useful therapeutic approach for disease prevention.
A Design Deviation Decreasing Methodology: Verified With a Piezoelectric Current Sensor (2019)

CAD and CAE approach have accelerated sensor design and optimization. But physical sensors tend to be accompanied with multi-physics interaction, making it hard to perform accurate 3D simulation of the sensors. Compared to 3D, 2D simulation’s computing expenses have decreased by 85%, while bringing about a maximum deviation up to 92%. In this paper, a methodology to decrease the deviation while simplifying 3D simulations of cantilever-based sensors into 2D ones are proposed and verified with a piezoelectric current sensor. To make up for the deviation, firstly, comprehensive 2D and 3D simulations are performed within a broad design space. Then, the deviation between 2D and 3D simulation under different design parameters are calculated. Finally, the design parameters and the deviation are used to train a neural network. After training, when new design parameters are input into the network, the corresponding deviation can quickly be predicted and used to revise 2D coarse simulation result. As a result, the deviation between 2D and 3D simulation is below 0.34%, which is a two order of magnitude decreasing compared to the result before being revised. This methodology can not only be used for the design and optimization of piezoelectric current sensor’s, but also can be potentially useful for other cantilever-based sensors, like piezoelectric mass and force sensor.
Cloud Adoption in Brazil (2017)

Cloud computing has become quite popular in recent years, and its use has the potential to provide scalable, cost-effective, and flexible IT services. These and other advantages have attracted the attention of academia, industry, and government. In Brazil, cloud computing technologies are already used by several industries, and the government is giving it serious consideration for IT services. This article aims to provide an overview of cloud adoption in Brazil by various governmental and industrial sectors. The authors also highlight the underlying technology's main challenges, discuss trends and projections related to cloud use in Brazil, and present governmental and university initiatives that promote cloud computing.
Modelling Angle Spread Autocorrelations and the Impact on Multi-User Diversity Gains (2010)

One way of modelling the wireless channel is in a statistical manner, based on a few parameters describing the characteristics of the environment. In most current wireless channel models, these key parameters are assumed independent between separate links, i.e. on the channels modelling the propagation between one base station and several mobile stations, or one mobile station and several base stations. In practice, dependencies between these wireless channels is expected and as a consequence, system performance evaluations based on models with independent links may be inaccurate. Herein, we consider simulations of a system that depend on the spatial nature of the channel. In particular, we study a system with multi-user scheduling using a single carrier. We investigate the impact of angle spread correlations on multi-user diversity gains using opportunistic scheduling. To facilitate this, a novel method of modelling the angle spread correlations for multi-user system simulations is developed. It is shown that in systems with multiple user scheduling, modelling the angle spread autocorrelation is necessary to obtain reliable system performance results, especially as the number of simultaneous scheduled users increases.
Numerical Simulation of an Untethered Omni-Directional Star-Shaped Swimming Robot (2021)

Simulating the swimming of soft underwater robot remains challenging due to the absence of an efficient numerical framework that can effectively capture the geometrically nonlinear deformation of soft materials and structures when interacting with a liquid environment. Here, we address this by introducing a discrete differential geometry-based model that incorporates an implicit treatment of the elasticity of soft limbs and a fluid model with three different components: hydrodynamic drag, jetting, and virtual added mass. The physical engine can run faster than real-time on a single thread desktop processor. We experimentally validate this numerical simulation tool by performing tests using an untethered omni-directional star-shaped swimming soft robot that is capable of moving with multiple swimming gaits. Quantitative agreement between experiment and simulation indicates the potential application of such a numerical framework for robot design and for model-based control schemes.
CMOS Photonics Technology Platform for High-Speed Optical Transceivers (2011)

We present a mature CMOS photonics technology platform suitable for design, simulation and manufacturing of a variety of high performance optical transceivers. We will highlight some key technology differentiators such as light coupling to optical fibers and very close integration of electronic and photonic devices. The capabilities of the technology platform are illustrated with some examples. Finally we present a roadmap towards higher speed, denser data transmission and closer integration with electronics circuits.
Development of Spectrally-Constrained Diffuse Optical Tomography for Imaging Exogenous Contrast Agents (2006)

Spectrally-constrained diffuse tomography is used to image endogenous and exogenous tissue chromophore concentrations with higher accuracy than when using individual wavelengths. Reconstructed images from simulated data demonstrate that concentrations of Lutetium Texaphyrin are readily recovered.
Mechanistic basis for the Iridium-Catalyzed Enantioselective Al-lylation of Alkenyl Boronates (2022)

Iridium(phosphoramidite) complexes catalyze an enantio- and diastereoselective three-component coupling reaction of alkenyl boronic esters, organolithium reagents and secondary allylic aryl carbonates. The reaction proceeds through an allylation-induced 1,2-metalate shift of the alkenyl boronate forming non-adjacent stereocenters. Mechanistic investiga-tions outline the overall catalytic cycle and reveal trends in reactivity and selectivity. Analysis of relative stereochemistry in a variety of 1,1-disubtituted alkenyl boronates provides insight into the transition state of the addition and indicates a concerted pathway. Kinetic analysis of the reaction revealed the kinetic order dependance in boronate, catalyst, and both the slow- and fast-reacting enantiomer of allylic carbonate as well as the turnover-limiting step of the reaction. Hammett studies explored substituent effects in both aryl-derived alkenyl boronates and aryl carbonates. Initial investigations into the migratory selectivity of the 1,2-metalate shift were also examined using (bis)alkenyl boronates.
Ultra low-supply voltage reference generator with low sensitivity to PVT variations (2013)

Majority of trim-less PVT insensitive voltage reference generators are limited to minimum supply voltage above 0.7 V. This delimits use of energy harvesting techniques in CMOS circuits and systems. This paper proposes a low-cost CMOS voltage reference, which steps up the supply voltage by charge-pump based voltage booster. The raised voltage helps to drive a traditional parasitic BJT based bandgap voltage reference. The proposed voltage reference scheme is analyzed theoretically and compared with other methods. The circuit is designed and simulated in standard 180 nm mixed mode CMOS technology. The minimum required supply voltage is 400 mV. A worst case temperature coefficient of 4 ppm/°C is achieved over 0-100°C temperature range. The reference voltage exhibits mean value of 169.37 mV with worst case deviation of ±1.35 mV across process corners and temperature range of 0-100°C. Achieved PSRR at 100 Hz and 1 MHz is -86 dB and -30 dB, respectively.
MLPerf Inference Benchmark (2019)

Machine-learning (ML) hardware and software system demand is burgeoning. Driven by ML applications, the number of different ML inference systems has exploded. Over 100 organizations are building ML inference chips, and the systems that incorporate existing models span at least three orders of magnitude in power consumption and five orders of magnitude in performance; they range from embedded devices to data-center solutions. Fueling the hardware are a dozen or more software frameworks and libraries. The myriad combinations of ML hardware and ML software make assessing ML-system performance in an architecture-neutral, representative, and reproducible manner challenging. There is a clear need for industry-wide standard ML benchmarking and evaluation criteria. MLPerf Inference answers that call. In this paper, we present our benchmarking method for evaluating ML inference systems. Driven by more than 30 organizations as well as more than 200 ML engineers and practitioners, MLPerf prescribes a set of rules and best practices to ensure comparability across systems with wildly differing architectures. The first call for submissions garnered more than 600 reproducible inference-performance measurements from 14 organizations, representing over 30 systems that showcase a wide range of capabilities. The submissions attest to the benchmark's flexibility and adaptability.
Cyclopropyl and Related Analogs of the Anti-HIV Compound, Isodideoxyadenosine (2003)

Novel 3'-substituted isonucleoside analogs were designed on the basis of the similarities of their electrostatic potential with the active anti-HIV compound, (S,S)-isodideoxy-adenosine. The key synthetic step involved coupling between the dideoxygenated sugar derivatives, 10 and 14, and adenine under Mitsunobu conditions. Anti-HIV data are mentioned.
Semiperfluoroalkyl Polyfluorenes for Orthogonal Processing in Fluorous Solvents (2010)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTSemiperfluoroalkyl Polyfluorenes for Orthogonal Processing in Fluorous SolventsJin-Kyun Lee†, Hon Hang Fong†, Alexander A. Zakhidov†, Georgia E. McCluskey‡, Priscilla G. Taylor†, Mitk'el Santiago-Berrios§, Héctor D. Abruña§, Andrew B. Holmes‡, George G. Malliaras†, and Christopher K. Ober*†View Author Information† Department of Materials Science and Engineering, Cornell University, Ithaca, New York 14853‡ School of Chemistry, Bio21 Institute, University of Melbourne, Victoria 3010, Australia§ Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853*Corresponding author. E-mail: [email protected]Cite this: Macromolecules 2010, 43, 3, 1195–1198Publication Date (Web):January 7, 2010Publication History Received2 October 2009Revised20 December 2009Published online7 January 2010Published inissue 9 February 2010https://pubs.acs.org/doi/10.1021/ma902179shttps://doi.org/10.1021/ma902179srapid-communicationACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views2635Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alkyls,Conjugated polymers,Materials,Polymers,Solvents Get e-Alerts
Oral Administration of Forskolin, Homotaurine, Carnosine, and Folic Acid in Patients with Primary Open Angle Glaucoma: Changes in Intraocular Pressure, Pattern Electroretinogram Amplitude, and Foveal Sensitivity (2016)

The results of the present pilot study indicate that the components of the food supplement reach the eye in a detectable manner, as evidenced by the effects on the IOP. Moreover, they suggest a short-term neuroactive effect, as indicated by the improvement of PERG amplitude and foveal sensitivity in treated, but not in control patients.
ADAM: An Adaptive Beamforming System for Multicasting in Wireless LANs (2013)

We present the design and implementation of ADAM, the first adaptive beamforming-based multicast system and experimental framework for indoor wireless environments. ADAM addresses the joint problem of adaptive beamformer design at the PHY layer and client scheduling at the MAC layer by proposing efficient algorithms that are amenable to practical implementation. ADAM is implemented on a field programmable gate array (FPGA) platform, and its performance is compared against that of omnidirectional and switched beamforming based multicast. Our experimental results reveal that: 1) switched multicast beamforming has limited gains in indoor multipath environments, whose deficiencies can be effectively overcome by ADAM to yield an average gain of threefold; 2) the higher the dynamic range of the discrete transmission rates employed by the MAC hardware, the higher the gains in ADAM's performance, yielding up to ninefold improvement over omni with the 802.11 rate table; and 3) finally, ADAM's performance is susceptible to channel variations due to user mobility and infrequent channel information feedback. However, we show that training ADAM's signal-to-noise ratio (SNR)-rate mapping to incorporate feedback rate and coherence time significantly increases its robustness to channel dynamics.
The rate equation based optical model for phosphor-converted white light-emitting diodes (2016)

An optical model based on the rate equation was developed to calculate the emission spectrum of a phosphor-converted white light-emitting diode (pc-WLED) taking into consideration the phosphor weight percentage, film thickness, and optical properties of phosphor, viz. absorption spectrum, quantum efficiency spectrum and fluorescent emission spectrum. Films containing a mixture of phosphor and silicone elastomer encapsulant were investigated using this model. A linear relationship was found between the peak absorption coefficient and the phosphor weight percentage with slopes of 66.76 ± 0.52 mm−1 and 29.66 ± 2.05 mm−1 for a red phosphor CaAlSiN3:Eu2+ and a yellow phosphor Y3Al5O12:Ce3+, respectively. With these parameters, the model predicted emission spectra which are in good agreement with measurement, thus verifying the validity of the model. The model correctly predicts redshift and spectral width reduction of the emission peak for increasing phosphor weight percentage or film thickness, as expected from the phenomenon of photon reabsorption by the phosphors. This model does not require the use of Monte Carlo simulation and Mie theory.
Alternative approach for direct APC using scatterometry data (2002)

Scatterometry is a promising method, capable of providing accurate profile information for a large range of applications. However, applying scatterometry to the production environment and applying it to APC is still difficult. In this paper we propose an alternative approach in which we apply a Neural Network to directly correlate scatterometry raw data and the lithography process control parameters. The proposed method is much easier to use than normal scatterometry, and can therefore be applied to APC much faster.
Functional domains of transcription factor TFIIB. (1993)

Transcription factor TFIIB is an essential component of the RNA polymerase II initiation complex. TFIIB carries out at least two functions: it interacts directly with the TATA-binding protein (TBP) and helps to recruit RNA polymerase II into the initiation complex. The sequence of TFIIB reveals a potential zinc-binding domain and an imperfect duplication of approximately 70 amino acids. Mutagenesis of cysteine codons within the putative zinc finger results in mutant proteins that bind normally to TBP but are unable to recruit RNA polymerase II-TFIIF into the initiation complex. Changing the two most highly conserved amino acids in the TFIIB repeats reduces the ability of TFIIB to interact with TBP. Therefore, the two functions of TFIIB can be assigned to two separable functional domains of the protein.
Characterisation and culture of primary human nasal epithelial cells and the influence of Interferon-gamma (2014)

Background The nasal epithelium with its tight junctions (TJs) represents an important barrier against the penetration of exogenous substances (e.g. allergens, pollutants and pathogens). Damage of the epithelium allows higher amounts of inhaled allergens and pollutants to penetrate the mucosa. Our laboratory has previously used a bronchial epithelial cell line to investigate epithelial damage by various factors [cigarette smoke (Gangl et al., 2009) and cytokines (Reisinger et al., 2005)]. Cultures of primary epithelial cells obtained from nasal epithelium should be superior in resembling the natural situation in the nose and allow a comparison of epithelia from non-allergic and allergic patients. Our aim was to establish primary human nasal epithelial cell culture in a transwell system and to investigate the epithelial barrier function and the properties of the nasal epithelium. Additionally we compared different epithelial cell culture systems to investigate damage and repair in primary human nasal epithelial cells.
GENETICALLY MODIFIED PIGS FOR MEDICINE AND AGRICULTURE (2012)

The ability to genetically modify pigs has enabled scientists to create pigs that are beneficial to humans in ways that were previously unimaginable. Improvements in the methods to make genetic modifications have opened up the possibilities of introducing transgenes, knock-outs and knock-ins with precision. The benefits to medicine include the production of pharmaceuticals, the provision of organs for xenotransplantation into humans, and the development of models of human diseases. The benefits to agriculture include resistance to disease, altering the carcass composition such that it is healthier to consume, improving the pig's resistance to heat stress, and protecting the environment. Additional types of genetic modifications will likely provide animals with characteristics that will benefit humans in currently unimagined ways.
ChemInform Abstract: DECARBALKOXYLATIONS OF GEMINAL DIESTERS AND BETA‐KETO ESTERS IN WET DIMETHYL SULFOXIDE, EFFECT OF ADDED SODIUM CHLORIDE ON THE DECARBALKOXYLATION RATES OF MONO‐ AND DISUBSTITUTED MALONATE ESTERS (1974)

Abstract Geminale Diester und β‐Ketoester werden beim Erhitzen mit feuchtem Dime thyl=, sulfoxid decarboxyliert, die Reaktion erfolgt auch in feuchtem Dimethylformamid.
Abstract 2911: SAR125844: a potent and selective ATP-competitive inhibitor of MET kinase (2012)

Abstract The tyrosine kinase MET is a membrane receptor that is essential for embryonic development and wound healing in normal cells. Stimulation of MET by its natural ligand, the hepatocyte growth factor (HGF), induces cell proliferation, migration, and invasion. Abnormal MET activation (over-expression of MET protein, amplification or mutations of the MET gene) has been observed in multiple human cancer types. We report herein the discovery of a potent and selective small molecule inhibitor (SAR125844) with potential therapeutic application in cancer patients with deregulated MET-dependent malignancies. Our initial hit identification approach was based on the biochemical screen of an in-house kinase inhibitor biased library where a series of benzimidazole sulfonate derivatives were identified with sub-micromolar MET inhibition. In particular, the initial hit exhibited an IC50 of 140 nM vs MET but it also had strong affinity for CDK9 (IC50= 6 nM), a CDK isoform involved in gene transcription. Chemical modifications of the series to dial out CDK9 affinity and remove potential normal cell cytotoxicity led to a more selective derivative with IC50's of 80nM and 1355nM vs MET and CDK9 respectively. Further sub-structural exploration allowed us to identify a heteorocyclic moiety which was shown by X-ray data to specifically interact with Tyr1230 in a non active conformation of the protein. The resulting highly favourable U-shape mode of binding in MET of representative examples from these series (e.g. IC50= 1nM) was not tolerated in CDK9 (IC50 &amp;gt; 10µM). Final multi-parametric medicinal chemistry optimisation led to SAR125844 with single digit nanomolar antiproliferative activity on MET-amplified cell lines. SAR125844 is highly selective for MET kinase in a panel of 275 kinases tested, with only 5 other protein kinases inhibited at IC50 values below 300 nM. This compound exhibits also satisfactory eADMET in vitro properties and has shown moderate total plasma clearance, large volume of distribution and moderate to long terminal elimination half-life in rats. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2911. doi:1538-7445.AM2012-2911
Protective coating on positive lithium-metal-oxide electrodes for lithium batteries (2023)

A positive electrode for a non-aqueous lithium cell comprising a LiMn<sub>2-x</sub>M<sub>x</sub>O<sub>4 </sub>spinel structure in which M is one or more metal cations with an atomic number less than 52, such that the average oxidation state of the manganese ions is equal to or greater than 3.5, and in which 0.ltoreq.x.ltoreq.0.15, having one or more lithium spine oxide LiM'<sub>2</sub>O<sub>4 </sub>or lithiated spinel oxide Li<sub>1+y</sub>M'<sub>2</sub>O<sub>4 </sub>compounds on the surface thereof in which M' are cobalt cations and in which 0.ltoreq.y.ltoreq.1.
Toward Self-Powered Internet of Underwater Things Devices (2020)

Exploiting light beams to carry information and deliver power is suggested as a potential technology to recharge batteries in future generations of IoT and IoUT devices while providing optical connectivity. SLIPT has been recently proposed as an efficient method of wireless power transfer between communicating terminals. In this article, we provide an overview of the various SLIPT techniques in the time, power, and space domains. We also demonstrate two SLIPT scenarios through underwater channels, and we discuss the issues related to the hardware as well as system deployment in harsh environments.