gebhart/patrepeval huggingface dataset:
Learning Suction Graspability Considering Grasp Quality and Robot Reachability for Bin-Picking (2022)

Deep learning has been widely used for inferring robust grasps. Although human-labeled RGB-D datasets were initially used to learn grasp configurations, preparation of this kind of large dataset is expensive. To address this problem, images were generated by a physical simulator, and a physically inspired model (e.g., a contact model between a suction vacuum cup and object) was used as a grasp quality evaluation metric to annotate the synthesized images. However, this kind of contact model is complicated and requires parameter identification by experiments to ensure real world performance. In addition, previous studies have not considered manipulator reachability such as when a grasp configuration with high grasp quality is unable to reach the target due to collisions or the physical limitations of the robot. In this study, we propose an intuitive geometric analytic-based grasp quality evaluation metric. We further incorporate a reachability evaluation metric. We annotate the pixel-wise grasp quality and reachability by the proposed evaluation metric on synthesized images in a simulator to train an auto-encoder-decoder called suction graspability U-Net++ (SG-U-Net++). Experiment results show that our intuitive grasp quality evaluation metric is competitive with a physically-inspired metric. Learning the reachability helps to reduce motion planning computation time by removing obviously unreachable candidates. The system achieves an overall picking speed of 560 PPH (pieces per hour).
Effect of Relative-Permeability Modifier Treatments in a sandstone-Layered System and in a Sandstone-Homogeneous System (1998)

By using chemical treatments in attempts to reduce the volumes of water produced from hydrocarbon-bearing strata, well operators face the risk of damaging productive intervals. To avert this problem, well operators often apply special placement techniques, (such as the use of the dual-injection technique and multiple-packer assembles) in attempts to focus water shutoff treatments into areas of interest. The special placement techniques require significant additional costs involving workover rigs, coiled-tubing units, multiple pumping units, tools, packers, and so on. Even when these precautions are taken, the chemical treatment may still enter the productive interval through any number of avenues, including the interzonal, communication, packer leaks or channels behind the pipe.The oil and gas industry is inherently attracted to relative permability modifiers (RPMs) because they have the potential to reduce the relative risk factors involved when conformance water-management treatments are performed on active, hydro-carbon-producing wells. The term RPM has been misused at times by being used to refer to porosity-fill sealants (such as metal-complexed polyacrylamide systems). Although organic, water-based systems may preferentially achieve deeper penetration into water-saturated strata than into hydrocarbon strata, those systems still result in the forming of sealants. The ideal RPM should reduce the effective permeabilit6y to water with no effect on the effective permeability to oil.The RPM materials available to the industry today are not ideal. These materials actually affect the effective permeability to both water and oil. The difference between and RPM and a sealant is that the RPM reduces the effective permeability to water more significantly than the effective permeability to oil.This paper discusses the results of testing two currently available RPMs through porous rock media. The testing includes evaluation of the RPMs in a layered system(high-permeability streaks of water though hydrocarbon-bearing strata) and evaluations of the RPMs in a homogeneous system with varying degrees of water saturation (transition zone between oil and water-bearing strata).P. 345
Unsymmetrical squaraines with new linkage manner for high-performance solution-processed small-molecule organic photovoltaic cells (2015)

Two unsymmetrical squaraines were employed as donors for high performance BHJ-OPV devices with <italic>J</italic><sub>sc</sub> &gt; 13 mA cm<sup>−2</sup> and PCE &gt; 5%.
A Switchable Linker‐Based Immunoassay for Ultrasensitive Visible Detection of Salmonella in Tomatoes (2017)

The novel switchable linker-based immunoassay is a rapid, specific, and sensitive method that has potential applications for routine diagnostics of Salmonella in tomato products. These advantages make it a practical approach for general use in the processing industry to detect Salmonella rapidly and to implement appropriate regulatory procedures. Furthermore, it could be applied to other fresh products including cantaloupe, strawberry, and cucumbers.
Particle-Substrate Interaction Forces in a Non-Polar Liquid (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Time-domain Modeling of Silver Nano-net for Transparent Conducting Electrodes (2013)

The transmittance of silver nano-net is simulated using the spectral averaging of a number of indiscriminately selected frames generated from the footprint of real sample. The simulated result shows a good match with experimental measurement.
Predicting Pediatric Patients Who Require Care at a Trauma Center: Analysis of Injuries and Other Factors (2017)

The TS metrics quantitatively describe age-specific transfer practices for children with particular injuries. This information can be useful in advanced automatic crash notification systems to alert first responders to the possibility of occult injuries and reduce undertriage of commonly missed injuries.
A metamaterial-enabled design enhancing decades-old short backfire antenna technology for space applications (2019)

Nearly two decades of intense study have passed since the term metamaterials was first introduced in 1999. In spite of their great promise, however, metamaterials have been slow to find their way into practical devices, and examples of real-world applications remain rare. In this paper, an Advanced Short Backfire Antenna (A-SBFA), augmented with anisotropic metamaterial surfaces (metasurfaces), has been designed to achieve a very high aperture efficiency across two frequency bands. This performance is unprecedented for an antenna that has seen widespread use, but few design changes over its more than 50 year existence. The reduced weight, compact design, hexagonal aperture, high dual-band efficiency, high cross-polarization isolation, as well as low multipaction and passive intermodulation (PIM) risk make the A-SBFA ideal for spaceborne applications. This transformative design demonstrates how practical metamaterials, when applied to conventional antenna technology, can provide significant performance enhancements.
From Consensus Sequence Peptide to High Affinity Ligand, a “Library Scan” Strategy (2001)

A wide variety of proteins have been shown to recognize and bind to specific amino acid sequences on other proteins. These sequences can be readily identified using combinatorial peptide libraries. However, peptides containing these preferred sequences ("consensus sequence peptides") typically display only modest affinities for the consensus sequence-binding site on the intact protein. In this report, we describe a parallel synthesis strategy that transforms consensus sequence peptides into high affinity ligands. The work described herein has focused on the Lck SH2 domain, which binds the consensus peptide acetyl-Tyr(P)-Glu-Glu-Ile-amide with a K(D) of 1.3 micrometer. We employed a strategy that creates a series of spatially focused libraries that challenge specific subsites on the target protein with a diverse array of functionality. The final lead compound identified in this study displayed a 3300-fold higher affinity for the Lck SH2 domain than the starting consensus sequence peptide.
Architectural Design Criteria for f-Block Metal Ion Sequestering Agents Final Report (2000)

No abstract prepared.
The NILE Project — Advances in the Conversion of Lignocellulosic Materials into Ethanol (2013)

NILE ("New Improvements for Lignocellulosic Ethanol") was an integrated European project (2005-2010) devoted to the conversion of lignocellulosic raw materials to ethanol. The main objectives were to design novel enzymes suitable for the hydrolysis of cellulose to glucose and new yeast strains able to efficiently converting all the sugars present in lignocellulose into ethanol. The project also included testing these new developments in an integrated pilot plant and evaluating the environmental and socio-economic impacts of implementing lignocellulosic ethanol on a large scale. Two model raw materials – spruce and wheat straw – both preconditioned with similar pretreatments, were used. Several approaches were explored to improve the saccharification of these pretreated raw materials such as searching for new efficient enzymes and enzyme engineering. Various genetic engineering methods were applied to obtain stable xylose- and arabinose-fermenting Saccharomyces cerevisiae strains that tolerate the toxic compounds present in lignocellulosic hydrolysates. The pilot plant was able to treat 2 tons of dry matter per day, and hydrolysis and fermentation could be run successively or simultaneously. A global model integrating the supply chain was used to assess the performance of lignocellulosic ethanol from an economical and environmental perspective. It was found that directed evolution of a specific enzyme of the cellulolytic cocktail produced by the industrial fungus, Trichoderma reesei, and modification of the composition of this cocktail led to improvements of the enzymatic hydrolysis of pretreated raw material. These results, however, were difficult to reproduce at a large scale. A substantial increase in the ethanol conversion yield and in specific ethanol productivity was obtained through a combination of metabolic engineering of yeast strains and fermentation process development. Pilot trials confirmed the good behaviour of the yeast strains in industrial conditions as well as the suitability of lignin residues as fuels. The ethanol cost and the greenhouse gas emissions were highly dependent on the supply chain but the best performing supply chains showed environmental and economic benefits. From a global standpoint, the results showed the necessity for an optimal integration of the process to co-develop all the steps of the process and to test the improvements in a flexible pilot plant, thus allowing the comparison of various configurations and their economic and environmental impacts to be determined.
The Binding Subunit of Pertussis Toxin Inhibits HIV Replication in Human Macrophages and Virus Expression in Chronically Infected Promonocytic U1 Cells (2001)

Abstract We have recently shown that the binding subunit of pertussis toxin (PTX-B) inhibits the entry and replication of macrophage-tropic (R5) HIV-1 strains in activated primary T lymphocytes. Furthermore, PTX-B suppressed the replication of T cell-tropic (X4) viruses at a postentry level in the same cells. In this study we demonstrate that PTX-B profoundly impairs entry and replication of the HIV-1ADA (R5), as well as of HIV pseudotyped with either murine leukemia virus or vesicular stomatitis virus envelopes, in primary monocyte-derived macrophages. In addition, PTX-B strongly inhibited X4 HIV-1 replication in U937 promonocytic cells and virus expression in the U937-derived chronically infected U1 cell line stimulated with cytokines such as TNF-α and IL-6. Of interest, TNF-α-mediated activation of the cellular transcription factor NF-κB was unaffected by PTX-B. Therefore, PTX-B may represent a novel and potent inhibitor of HIV-1 replication to be tested for efficacy in infected individuals. In support of this proposition, a genetically modified mutant of PTX (PT-9K/129G), which is safely administered for prevention of Bordetella pertussis infection, showed an in vitro anti-HIV profile superimposable to that of PTX-B.
Inaugural Charles River World Congress on Animal Models in Drug Discovery and Development (2017)

We developed two cancer vaccine platforms in mouse models and translated these into human clinical trials with promising preliminary results. First, we studied TARP, a prostate cancer antigen discovered at NCI [1], mapping HLA-A2-presented epitopes, and testing these in HLA-A2-transgenic mice [2]. We then modified the amino acid sequences to improve binding to HLA-A2, and tested in mouse models whether the modified peptides were more immunogenic and induced T cells that recognized the unmodified peptide. We call this process "epitope enhancement. " We confirmed that the enhanced peptides could stimulate human T cells in vitro to kill human cancer cells expressing HLA-A2 and TARP [2]. The mouse studies led to our phase I clinical trial in patients with stage D0 prostate cancer, in which the primary tumor is removed but a rising PSA indicates microscopic recurrence, before any tumor can be seen radiographically. Patients were immunized with 2 TARP peptides either in Montanide-ISA51 or pulsed onto autologous dendritic cells (DCs). Because there was no difference in outcomes, we could pool the arms for higher statistical power. At 6 months >71% of the patients had a decreased rate of PSA rise (p = 0.0012), which has been shown to be a valid predictor of outcome. At 1 year, 74% of patients had a decreased PSA slope (p = 0.0004). By fitting to an exponential growth curve, the median tumor growth rate constant was cut in half [3]. A randomized, placebocontrolled phase II study is underway with a broader set of TARP peptides to avoid restriction to HLA-A2 patients. Second, we developed a vaccine targeting the HER2 oncogene, responsible for about of breast cancers and a smaller % of several other cancers. For mice, we made an adenovirus expressing the extracellular and transmembrane domains of rodent HER2. In HER2-transgenic BALB/c mice that inexorably develop tumors in all 10 mammary glands, early vaccination could prevent tumor appearance [4, 5]. In wild-type BALB/c mice injected with TUBO tumor cells from the transgenic mice, the vaccine cured large (2-cm) established tumors and lung metastases [6]. The mechanism, surprisingly, was purely antibody mediated, by antibodies inhibiting HER2 phosphorylation, and was FcR independent, unlike trastuzumab. We are engaged in a clinical trial in patients with advanced metastatic HER2 + tumors who have failed other therapies. Among patients nave to trastuzumab, in the second and third dose cohorts, 5/11 patients had some clinical benefit. Thus, two cancer vaccine platforms developed in transgenic mouse models were successfully translated to human trials with promising results.
Anti-Stokes fluorescence cooling in Yb-doped ZBLAN fibers at atmospheric pressure: experiments and near-future prospects (2019)

We report for the first time cooling by anti-Stokes fluorescence (ASF) of a single-mode fiber, and cooling of a fiber at atmospheric pressure. This demonstration and the ability of our model to accurately predict cooling are crucial steps towards the development of radiation-balanced fiber lasers and were the primary focus of this work. We also experimentally investigated the effects of pump power and wavelength, the core size, and the dopant concentration on ASF cooling, in order to maximize this process. Experiments were performed on two Yb-doped ZBLAN fiber from Le Verre Fluoré: a single-mode fiber doped with 1 mol% Yb and a multimode fiber doped with 3 mol% Yb. The maximum temperature change achieved in the two fibers was -5.2 mK and -0.64 K, respectively, confirming that cooling scales with doped area. However, we also discuss limitations to this scaling, namely the absorptive loss, concentration quenching, and the mode profile of the pump. We use our previously reported model to quantify these scarcely reported parameters. For the multimode fiber, comparison between the experimental data and the model gave an inferred absorptive loss of 45 dB/km and a critical quenching concentration of 3.57x10<sup>27</sup> m<sup>-3</sup>. In addition to these parameters, accurate modeling also requires precise knowledge of the absorption and emission cross-sections. To this end, we propose a method to obtain spectra that obey the McCumber relation and accurately represent the material under investigation. Finally, we report on the cooling efficiencies achieved in the single-mode (2.0%) and multimode (0.85%) fibers and show that the efficiency decreases with increasing pump power due to absorptive loss.
Expression of luteinizing hormone and chorionic gonadotropin receptor messenger ribonucleic acid in human corpora lutea during menstrual cycle and pregnancy. (1995)

In the present study, we examined the expression of LH and CG receptor messenger RNA (mRNA) in human corpora lutea (CL) during the menstrual cycle and pregnancy. Poly(A)-enriched RNA was extracted from CL and analyzed by Northern and slot blots, using a radiolabeled complementary RNA probe derived from the human LH receptor complementary DNA. Northern blot analysis indicated the presence of multiple LH receptor mRNA transcripts with molecular sizes of 8.0, 7.0 and 4.5 kilobases in human CL during the menstrual cycle. The predominant transcript was 4.5 kilobases in size. However, no hybridization signals were observed in nongonadal tissues (heart, liver, and kidney). Densitometric analyses revealed that the levels of LH receptor mRNA increased from early luteal phase to midluteal phase and subsequently decreased during late luteal phase. After the onset of menstruation, the LH receptor mRNA level was undetectable in the regressing CL. Moreover, radioligand receptor assay (RRA) showed a close parallelism between LH receptor mRNA levels and LH receptor content in CL throughout the menstrual cycle. LH receptor mRNA expression was also found in CL during early pregnancy. The level of LH receptor mRNA was relatively high in early pregnancy CL, whereas LH receptor content was low. Using in situ hybridization, LH receptor mRNAs were uniformly expressed in both large and small luteal cells during early and midluteal phase and early pregnancy, but not in regressing CL. In conclusion, these data demonstrate that the regulation of LH receptor content in human CL during luteal phase is associated with similar changes in the receptor message levels, suggesting the physiological roles for LH receptor mRNA during the menstrual cycle in the human. In addition, the expression of LH receptor mRNA was demonstrated in human CL during early pregnancy.
Altered neutrophil immunophenotypes in childhood B-cell precursor acute lymphoblastic leukemia (2016)

An increasing number of evidences suggest a genetic predisposition in acute lymphoblastic leukemia (ALL) that might favor the occurrence of the driver genetic alterations. Such genetic background might also translate into phenotypic alterations of residual hematopoietic cells. Whether such phenotypic alterations are present in bone marrow (BM) cells from childhood B-cell precursor (BCP)-ALL remains to be investigated. Here we analyzed the immunophenotypic profile of BM and peripheral blood (PB) maturing/matured neutrophils from 118 children with BCP-ALL and their relationship with the features of the disease. Our results showed altered neutrophil phenotypes in most (77%) BCP-ALL cases. The most frequently altered marker was CD10 (53%), followed by CD33 (34%), CD13 (15%), CD15/CD65 (10%) and CD123 (7%). Of note, patients with altered neutrophil phenotypes had younger age (p = 0.03) and lower percentages of BM maturing neutrophils (p = 0.004) together with greater BM lymphocyte (p = 0.04), and mature B-cell (p = 0.03) counts. No significant association was found between an altered neutrophil phenotype and other disease features. These findings point out the potential existence of an altered residual hematopoiesis in most childhood BCP-ALL cases.
Abstract 12523: Color M-Mode Echocardiography Derived Left Ventricular Diastolic Indices in Infants Strongly Correlate With Left Ventricular Linear Dimensions (2018)

Introduction: Color M-mode (CMM) has been shown to be a reliable method to assess ventricular diastolic function in adults. We analyzed left ventricular (LV) diastology in children from birth to tw...
Complexation-induced N‒P axial chirality in Sm(II) N -phosphine oxide-substituted imidazolylidene and imidazolinylidene complexes (2022)

Two types of Sm(II) complexes bearing either an N-phosphine oxide-substituted imidazolylidene (PoxIm) or the corresponding imidazolinylidene (SPoxIm) were successfully prepared and characterized using single-crystal X-ray diffraction analysis. The general formula of the structures of the complexes was found to be ( anti-κ-O-(S)PoxIm) n SmX 2 (THF) m where X = I, n = 2, and m = 2 or X = pentamethylcyclopentadienyl, n = 1, and m = 0. The carbene carbon atoms remained intact in these complexes. In some cases, axial chirality was clearly induced around the N‒P bonds due to the restricted rotation of the N-phosphinoyl moieties, which arises from the formation of N-phosphinoyl oxygen‒Sm(II) bonds. This work highlights a rare example of complexation-induced N‒P axial chirality and new aspects regarding lanthanide complexes of multifunctional multipurpose carbenes.
Tunability of the interlayer exchange coupling (2002)

The effect of the interlayer exchange coupling on the ordering temperature of ultrathin magnetic layers has been explored for two systems: Ho/Y and Fe/V superlattices. In both cases, the exchange coupling can be modified and eventually removed by the introduction of hydrogen into the mediating non-magnetic spacer layer. In case of Ho/Y we observed a drastic drop of the Ho Néel temperature from 105 K for coupled Ho blocks of 10 monolayer thickness to 65 K for isolated or uncoupled Ho blocks. In Fe/V superlattices, the incorporation of hydrogen changes the strength and sign of the exchange coupling constant. Again, we observed that the ordering temperature clearly depends on the strength of the exchange coupling in both the antiferromagnetically and the ferromagnetically coupled range of the phase diagram.
Demonstration of high-efficient InGaN-based violet light-emitting diodes with an external-quantum efficiency of more than 40% (2003)

High-power InGaN-based violet light-emitting diodes (LEDs), which were fabricated on patterned-sapphire substrate (PSS), have been realized. In order to improve the extraction efficiency in the LEDs, the PSS configuration was optimized by means of photoluminescence (PL). With increasing depth of grooves (Dg) in the PSS, the interference fringes observed in the PL spectrum declined and almost disappeared at Dg = 1 μm. The PL and electroluminescence (EL) intentensities also increased with increasing Dg. These results indicated that the contribution of optical loss resulting from multiplex reflection decreased with increasing Dg, and the extraction efficiency was also improved. When the LEDs on the optimized PSS were operated at 20 mA, the wavelength, the output power and the external-quantum efficiency were estimated to be 403 nm, 26.2 mW and 43%, respectively. (© 2003 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)