gebhart/patrepeval huggingface dataset:
Liposomal cytarabine for treatment of myeloid central nervous system relapse in chronic myeloid leukaemia occurring during imatinib therapy (2007)

'Anatomic' resistance against imatinib in the CNS can lead to a myeloid CNS relapse. Liposomal cytarabine with or without radiation is effective as local therapy in these patients. For systemic treatment and prophylaxis, BCR/ABL kinase inhibitors crossing the blood-brain barrier such as dasatinib should be considered in patients with CNS relapse.
Orthorhombic analysis of the SEAM Phase II model (2020)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2020Orthorhombic analysis of the SEAM Phase II modelAuthors: Bruce W. HootmanEdan GoferScott LeaneyColin M SayersBruce W. HootmanWesternGeco, Edan GoferWesternGeco, Scott LeaneyWesternGeco, and Colin M SayersWesternGecohttps://doi.org/10.1190/segam2020-3427990.1 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail AbstractAzimuthal anisotropy analysis of both velocity and reflection amplitude variations for land seismic data has gained popularity over the last twenty years following the advent of wide-azimuth and long-offset data acquisition (Lynn et. al., 1996: Mallick, 1996). These types of seismic data allow us to estimate the magnitude and orientation of azimuthal anisotropy of the reflection amplitudes and kinematic variations. Using a suitable geomechanical interpretation, we can link these seismic attributes to fracture density, fracture orientation, and the in-situ stress. This is important because these can be used to aid in hydraulic fracturing, design, and horizontal well placement. Generally, there are two techniques to evaluate azimuthal anisotropy: azimuthal velocity analysis and azimuthal amplitude analysis and inversion. Over the last twenty-five years, numerous publications describe successes of these techniques, such as Narhari et. al. (2015) and Lynn et. al. (2014a, 2014b). But, recently, there have been some opposing opinions as well (Rauch-Davies et. al., 2019: Van De Coevering et. al., 2019). The claim is that these effects are very subtle and often lost in the noise and data processing required to produce good images. Furthermore, azimuthal variations can appear to be geologic, but have nothing to do with the geology at the reservoir. With this in mind, we began our study of the SEAM Phase II model and synthetic with the goal of discovering what factors control the success and failure of various analyses.Presentation Date: Tuesday, October 13, 2020Session Start Time: 8:30 AMPresentation Time: 8:30 AMLocation: 361APresentation Type: OralKeywords: anisotropy, rock physics, depth migration, velocity analysis, moveoutPermalink: https://doi.org/10.1190/segam2020-3427990.1FiguresReferencesRelatedDetailsCited ByThe SEAM Barrett model: Strengths and weaknessesHeloise Lynn, Colin M. Sayers, and Benjamin Roure2 August 2021 | GEOPHYSICS, Vol. 86, No. 5 SEG Technical Program Expanded Abstracts 2020ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2020 Pages: 3887 publication data© 2020 Published in electronic format with permission by the Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 25 Sep 2020 CITATION INFORMATION Bruce W. Hootman, Edan Gofer, Scott Leaney, and Colin M Sayers, (2020), "Orthorhombic analysis of the SEAM Phase II model," SEG Technical Program Expanded Abstracts : 141-145. https://doi.org/10.1190/segam2020-3427990.1 Plain-Language Summary Keywordsanisotropyrock physicsdepth migrationvelocity analysismoveoutPDF DownloadLoading ...
Effects of N2Gas Pressure Sintering on the Surface and Strength of Si3N4 (1988)

The flexural strength of Si{sub 3}N{sub 4} having an as-sintered surface was measured to investigate the effects of the sintering atmosphere on the surface. The as-sintered strength of Si{sub 3}N{sub 4} fires in 0.1 MPa N{sub 2} (pressureless sintering) degraded to 39% of its ground strength as a result of near-surface voids formed by thermal decomposition reactions between Si{sub 3}N{sub 4} and additive oxides. The as-sintered strength of Si{sub 3}N{sub 4} fired at 70 MPa N{sub 2} (gas pressure sintering), however, was shown to retain as much as 76% of its ground strength. This result seems to indicate that high-pressure N{sub 2} gas suppressed the void formation by reducing the decomposition reactions. Gas pressure sintering was effective in avoiding thermal decomposition and in maintaining a higher as-sintered strength.
Influence of palm oil or its tocotrienol-rich fraction on the lipid peroxidation potential of rat liver mitochondria and microsomes. (1993)

The effect of palm oil, a widely used vegetable oil, rich in tocotrienols, on peroxidation potential of rat liver was examined. Long-term feeding of rats with palm oil as one of the dietary components significantly reduced the peroxidation potential of hepatic mitochondria and microsomes. As compared to hepatic mitochondria isolated from rats fed control or corn oil-rich diet, those from palm oil-fed group showed significantly less susceptibility to peroxidation induced by ascorbate and NADPH. However, in microsomes, only NADPH-induced lipid peroxidation was significantly reduced in rats fed palm oil rich-diet. Though the accumulation of thiobarbituric acid reactive substances during ascorbate-induced lipid peroxidation in mitochondria from rats fed corn oil-rich diet supplemented with tocotrienol-rich fraction (TRF) of palm oil was similar to that of control rats, the initial rate of peroxidation was much slower than those from control or corn oil fed diets. Our in vitro studies as well as analyses of co-factors related to peroxidation potential indicated that the observed decrease in palm oil-fed rats may be due to increased amount of antioxidants in terms of tocotrienol as well as decrease in the availability of substrates for peroxidation.
The POSS side chain epoxy nanocomposite: Synthesis and thermal properties (2010)

Abstract The IPI‐POSS‐modified epoxy resin (IPEP) was prepared from isocyanato‐propyldinethylsilyl‐isobutyl‐POSS (IPI‐POSS) and diglycidyl ether of bisphenol A epoxy resin. The steric hindrance of the IPEP bulky POSS side chain improved the curing activation energies. The POSS particles sizes were about 2–3 nm and dispersed uniformly. At lower IPEP concentration (POSS &lt; 12 wt %), the glass transition temperatures ( T g s) of the IPEP nanocomposites increased from 118 to 170 °C. The char yield increased from 15 to 20 wt %, and the LOI values increased from 22 to 28. © 2010 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 48: 643–652, 2010
Superposition Coding Is Almost Always Optimal for the Poisson Broadcast Channel (2016)

This paper shows that the capacity region of the continuous-time Poisson broadcast channel is achieved via superposition coding for most channel parameter values. Interestingly, the channel in some subset of these parameter values does not belong to any of the existing classes of broadcast channels for which superposition coding is optimal (e.g., degraded, less noisy, and more capable). In particular, we introduce the notion of effectively less noisy broadcast channel and show that it implies less noisy but is not in general implied by more capable. For the rest of the channel parameter values, we show that there is a gap between Marton’s inner bound and the UV outer bound.
Multiple substrate recognition by yeast diadenosine and diphosphoinositol polyphosphate phosphohydrolase through phosphate clamping (2021)

The yeast diadenosine and diphosphoinositol polyphosphate phosphohydrolase DDP1 is a Nudix enzyme with pyrophosphatase activity on diphosphoinositides, dinucleotides, and polyphosphates. These substrates bind to diverse protein targets and participate in signaling and metabolism, being essential for energy and phosphate homeostasis, ATPase pump regulation, or protein phosphorylation. An exhaustive structural study of DDP1 in complex with multiple ligands related to its three diverse substrate classes is reported. This allowed full characterization of the DDP1 active site depicting the molecular basis for endowing multisubstrate abilities to a Nudix enzyme, driven by phosphate anchoring following a defined path. This study, combined with multiple enzyme variants, reveals the different substrate binding modes, preferences, and selection. Our findings expand current knowledge on this important structural superfamily with implications extending beyond inositide research. This work represents a valuable tool for inhibitor/substrate design for <i>Sc</i>DDP1 and orthologs as potential targets to address fungal infections and other health concerns.
Design of a retinal tracking system for jumping spiders (2011)

We designed an optical system for tracking the retinal movement of a jumping spider as a stimulus is presented to it. The system, using all off-the-shelf optical components except for one custom aspheric plate, consists of three sub-systems that share a common path: a visible stimuli presentation sub-system, a NIR illumination sub-system, and a NIR retinal imaging sub-system. A 25 mm clearance between the last element and the spider ensures a stable positioning of the spider. The stimuli presentation system relays an image from a display to the spider eye, matching the 15 arcmin resolution of the two principal eyes and producing a virtual image at a distance of 255 mm from the spider, with a visual full field of view of 52&deg;. When viewing a stimulus, the spider moves its retinas, which cover a full field of view of only 0.6&deg;, and directs them to view different places in the visual field. The retinal imaging system uses a NIR camera to track changes of 0.5&deg; in the field of view seen by the spider. By tracking retinal movement across images presented to spiders, we will learn how they search for visual cues to identify prey, rivals, and potential mates.
High resolution IR absorption spectroscopy of the OH stretch modes in SrTiO3:Fe (1990)

Abstract Sidebands of the main OH stretch mode in SrTiO3 shown to originate from interactions with Fe impurities are investigated. The number of OH stretch modes in SrTiO3 increases with Fe-doping. The intensities of the absorption lines depend strongly on annealing treatments. We have studied these lines with respect to the temperature dependence of the vibrational frequencies, the dependence on light polarization and the splitting patterns under static electric fields. For an interpretation we propose hydrogen sites associated with both iron impurities and oxygen vacancies.
Structural basis for bathochromic shift of fluorescence in far-red fluorescent proteins eqFP650 and eqFP670 (2012)

The crystal structures of the far-red fluorescent proteins (FPs) eqFP650 (λ(ex)(max)/λ(em)(max) 592/650 nm) and eqFP670 (λ(ex)(max)/λ(em)(max) 605/670 nm), the successors of the far-red FP Katushka (λ(ex)(max)/λ(em)(max) 588/635 nm), have been determined at 1.8 and 1.6 Å resolution, respectively. An examination of the structures demonstrated that there are two groups of changes responsible for the bathochromic shift of excitation/emission bands of these proteins relative to their predecessor. The first group of changes resulted in an increase of hydrophilicity at the acylimine site of the chromophore due to the presence of one and three water molecules in eqFP650 and eqFP670, respectively. These water molecules provide connection of the chromophore with the protein scaffold via hydrogen bonds causing an ~15 nm bathochromic shift of the eqFP650 and eqFP670 emission bands. The second group of changes observed in eqFP670 arises from substitution of both Ser143 and Ser158 by asparagines. Asn143 and Asn158 of eqFP670 are hydrogen bonded with each other, as well as with the protein scaffold and with the p-hydroxyphenyl group of the chromophore, resulting in an additional ~20 nm bathochromic shift of the eqFP670 emission band as compared to eqFP650. The role of the observed structural changes was verified by mutagenesis.
Differential MMSE: A Framework for Robust Adaptive Interference Suppression for Direct-Sequence CDMA Over Fading Channels (2005)

Differential MMSE: A Framework for Robust Adaptive Interference Suppression for Direct-Sequence CDMA Over Fading Channels The linear minimum mean-squared error (MMSE) criterion is known to provide adaptive algorithms for interference suppression in direct-sequence code-division multiple-access (DS-CDMA) systems. However, standard MMSE adaptation is not robust to fast fading, being unable to compensate for rapid channel variations. We provide a framework for deriving robust adaptive algorithms in this setting based on a new differential MMSE (DMMSE) criterion, which is a constrained optimization problem in which the quantity to be tracked is the ratio of the data appearing in two successive observation intervals. When applied to a DS-CDMA system with short spreading waveforms (i.e., with period equal to the symbol interval) operating over a flat fading channel, the DMMSE criterion avoids tracking the fades, exploiting the negligible variation of the fading gain over two consecutive symbols. For frequency-selective fading, the DMMSE criterion is extended to provide a new eigenrake receiver, which provides interference suppression and diversity combining without requiring explicit information regarding the desired user's propagation channel.
Chapter 12. Study of the Relationship Between Flammability and Melt Rheological Properties of Flame-Retarded Poly(Butylene Terephthalate) Containing Nanoclays (2009)

Recent studies on a new class of flame retardant (FR) systems that contain nanoclay and conventional FR microparticles have shown that the threshold concentration of FR required to achieve acceptable levels of flame retardancy can be significantly reduced in the presence of nanoclay. Bourbigot et al...
Nanophotonic Biosensors: from Plasmonic to Dielectric Metasurfaces (2019)

Mobile and affordable biosensors enabling detection of disease biomarkers from small sample volumes are essential for next-generation healthcare systems. Here, I will introduce ultrasensitive compact biosensors and label-free large-area biomolecule imagers based on nanophotonic metasurfaces.
3-(4-Hydroxymethylphenoxy)propionic Acid (2003)

[101366-61-4] C10H12O4 (MW 196.20) InChI = 1S/C10H12O4/c11-7-8-1-3-9(4-2-8)14-6-5-10(12)13/h1-4,11H,5-7H2,(H,12,13) InChIKey = WPWKJUVXEMKOHS-UHFFFAOYSA-N (acid-labile linker/handle used for solid-phase synthesis of peptide acids, and more general applications to solid-phase organic synthesis) Alternate Name: p-alkoxybenzyl (PAB) ester linker. Physical Data: mp 149–150 °C, analytically calculatedfor C10H12O4; C, 61.22; H, 6.17. Found: C, 61.08; H, 6.19. Solubility: soluble in most polar organic solvents. Form Supplied in: the title compound is a crystalline solid. The title compound and variations can be obtained on-resin with or without anchored protected amino acid moieties. See main text for further details. Analysis of Reagent Purity: NMR, elemental analysis, TLC, or other chromatographic criteria. Preparative Methods: it can be prepared by alkylation of 4-hydroxybenzaldehyde with 3-bromopropionic acid, followed by NaBH4 reduction of aldehyde to alcohol. Purification: recrystallization from minimal MeOH–EtOAc (1:1), adding chilled pentane. Handling, Storage, and Precautions: routine procedure is followed. Details depend on whether materials are solid organic compounds, are attached to a solid support, and/or include protected amino acid moieties. If possible, materials should be refrigerated to increase shelf life. Disposal: these materials are not particularly hazardous, and standard methods for solid organic waste disposal should be adequate.
Skeletal Diversity through Radical Cyclization of Tetrahydropyridine Scaffolds (2007)

Suitably functionalized tetrahydropyridines (methyl pipecolates) have been used as conformationally biased templates for radical cyclizations to access benzoisoquinuclidines and linearly fused indenopiperidines. Variation of skeletal types is determined by location of a radical-initiating element.
Improving power losses and thermal management in switch mode power converters using multiple transformers (2021)

Presently, DC power supply requirements in electronic applications are met by switch mode power converters. With the advent of high capacity semiconductor devices such as SIC MOSFETs and diodes, the power delivered by converters can be very comfortably enhanced. Nevertheless, the magnetic components such as the power transformers may limit the power delivery because of their thermal resistances and temperature management. Also, the geometry and the size of one single transformer may be a limiting factor for power delivery, though the other devices are rated high. In this paper, a simple technique to parallel multiple small transformers to enhance the power rating of the converter while guaranteeing the power sharing among the transformers is proposed. Two DC-DC forward converters are designed and fabricated, one with single larger transformer and another with two smaller transformers with identical specifications. The test results are presented validating the proposed technique.
Adaptive sparse system identification using wavelets (2002)

This paper proposes the use of wavelets for the identification of an unknown sparse system whose impulse response (IR) is rich in spectral content. The superior time localization property of wavelets allows for the identification and subsequent adaptation of only the nonzero IR regions, resulting in lower complexity and faster convergence speed. An added advantage of using wavelets is their ability to partially decorrelate the input, thereby further increasing convergence speed. Good time localization of nonzero IR regions requires high temporal resolution while good decorrelation of the input requires high spectral resolution. To this end we also propose the use of biorthogonal wavelets which fulfil both of these two requirements to provide additional gain in performance. The paper begins with the development of the wavelet-basis (WB) algorithm for sparse system identification. The WB algorithm uses the wavelet decomposition at a single scale to identify the nonzero IR regions and subsequently determines the wavelet coefficients of the unknown sparse system at other scale levels that require adaptation as well. A special implementation of the WB algorithm, the successive-selection wavelet-basis (SSWB), is then introduced to further improve performance when certain a priori knowledge of the sparse IR is available. The superior performance of the proposed methods is corroborated through simulations.
MR-Guided Ultrasonic Brain Therapy: High Frequency Approach (2010)

A novel MR‐guided brain therapy device operating at 1 MHz has been designed and constructed. The system has been installed and tested in a clinical 1.5 T Philips Achieva MRI. Three dimensional time domain finite differences simulations were used to compute the propagation of the wave field through three human skulls. The simulated phase distortions were used as inputs for transcranial correction and the corresponding pressure fields were scanned in the focal plane. At half of the maximum power (10 W/cm2 on the surface of the transducers), necroses were induced 2 cm deep in turkey breasts placed behind a human skull. In vitro experiments on human skulls show that simulations restore more than 85% of the pressure level through the skull bone when compared to a control correction performed with an implanted hydrophone. Finally, high power experiments are performed though the skull bone and a MR‐Thermometry sequence is used to map the temperature rise in a brain phantom every 3 s in two orthogonal planes (focal plane and along the axis of the probe).
Data from HORMAD1 Is a Negative Prognostic Indicator in Lung Adenocarcinoma and Specifies Resistance to Oxidative and Genotoxic Stress (2023)

&lt;div&gt;Abstract&lt;p&gt;Cancer testis antigens (CTA) are expressed in testis and placenta and anomalously activated in a variety of tumors. The mechanistic contribution of CTAs to neoplastic phenotypes remains largely unknown. Using a chemigenomics approach, we find that the CTA HORMAD1 correlates with resistance to the mitochondrial complex I inhibitor piericidin A in non–small cell lung cancer (NSCLC). Resistance was due to a reductive intracellular environment that attenuated the accumulation of free radicals. In human lung adenocarcinoma (LUAD) tumors, patients expressing high HORMAD1 exhibited elevated mutational burden and reduced survival. HORMAD1 tumors were enriched for genes essential for homologous recombination (HR), and HORMAD1 promoted RAD51-filament formation, but not DNA resection, during HR. Accordingly, HORMAD1 loss enhanced sensitivity to γ-irradiation and PARP inhibition, and HORMAD1 depletion significantly reduced tumor growth &lt;i&gt;in vivo&lt;/i&gt;. These results suggest that HORMAD1 expression specifies a novel subtype of LUAD, which has adapted to mitigate DNA damage. In this setting, HORMAD1 could represent a direct target for intervention to enhance sensitivity to DNA-damaging agents or as an immunotherapeutic target in patients.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Significance:&lt;/b&gt; This study uses a chemigenomics approach to demonstrate that anomalous expression of the CTA HORMAD1 specifies resistance to oxidative stress and promotes HR to support tumor cell survival in NSCLC. &lt;i&gt;Cancer Res; 78(21); 6196–208. ©2018 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Data from Toxicity and Efficacy of a Novel GADD34-expressing Oncolytic HSV-1 for the Treatment of Experimental Glioblastoma (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Glioblastoma (GBM) is the most common primary central nervous system cancer in adults. Oncolytic HSV-1 (oHSV) is the first FDA-approved gene therapy approach for the treatment of malignant melanoma. For GBM, oHSVs need to be engineered to replicate within and be toxic to the glial tumor but not to normal brain parenchymal cells. We have thus engineered a novel oHSV to achieve these objectives.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; NG34 is an attenuated HSV-1 with deletions in the genes encoding viral ICP6 and ICP34.5. These mutations suppress virus replication in nondividing brain neurons. NG34 expresses the human &lt;i&gt;GADD34&lt;/i&gt; gene under transcriptional control of a cellular Nestin gene promoter/enhancer element, whose expression occurs selectively in GBM. &lt;i&gt;In vitro&lt;/i&gt; cytotoxicity assay and survival studies with mouse models were performed to evaluate therapeutic potency of NG34 against glioblastoma. &lt;i&gt;In vivo&lt;/i&gt; neurotoxicity evaluation of NG34 was tested by intracerebral inoculation.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; NG34 replicates in GBM cells &lt;i&gt;in vitro&lt;/i&gt; with similar kinetics as those exhibited by an oHSV that is currently in clinical trials (rQNestin34.5). Dose–response cytotoxicity of NG34 in human GBM panels was equivalent to or improved compared with rQNestin34.5. The &lt;i&gt;in vivo&lt;/i&gt; efficacy of NG34 against two human orthotopic GBM models in athymic mice was similar to that of rQNestin34.5, whereas intracerebral injection of NG34 in the brains of immunocompetent and athymic mice showed significantly better tolerability. NG34 was also effective in a syngeneic mouse glioblastoma model.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; A novel oHSV encoding &lt;i&gt;GADD34&lt;/i&gt; is efficacious and relatively nontoxic in mouse models of GBM. &lt;i&gt;Clin Cancer Res; 24(11); 2574–84. ©2018 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;