gebhart/patrepeval huggingface dataset:
Multifunctionalization of Poly(vinylidene fluoride)/Reactive Copolymer Blend Membranes for Broad Spectrum Applications (2016)

Simultaneous immobilization and cross-linking of antifouling/low toxic polymers, e.g., poly(ethylenimine) (PEI), dextran (Dex), agarose (Agr), poly(ethylene glycol) (PEG), PEI-Dex, and PEI-PEG conjugates, and stimuli-responsive copolymers on a porous membrane surface in mild reaction conditions is desirable for the enhancement of hydrophilicity, antifouling character, cytocompatibility, and inducing stimuli-responsive behavior. Grafting to technique is required since the precursors of most of these macromolecules are not amenable to surface-initiated polymerization. In this work, we report a versatile process for the simultaneous immobilization and cross-linking of a library of macromolecules on and into the blend membrane (PVDF-blend) of poly(vinylidene fluoride) and poly(methyl methacrylate)-co-poly(chloromethylstyrene). Sequential nucleophilic substitution reaction between activated halide moieties of the copolymer and amine groups of different macromolecules readily provided series of modified membranes. These membranes exhibited antifouling property superior to that of the unmodified membrane. The effectiveness of this technique has been demonstrated by the immobilization of pH or both pH- and temperature-responsive copolymer on PVDF-blend membrane for responsive separation of poly(ethylene oxide) and bovine serum albumin. Silver nanoparticles were also anchored on the select modified membranes surfaces for the enhancement of antibiofouling property. Our approach is useful to obtain verities of functional membranes and selection of membrane for a particular application.
Mapping the HLA Ligandome of Colorectal Cancer Reveals an Imprint of Malignant Cell Transformation (2018)

Immune cell infiltrates have proven highly relevant for colorectal carcinoma prognosis, making colorectal cancer a promising candidate for immunotherapy. Because tumors interact with the immune system via HLA-presented peptide ligands, exact knowledge of the peptidome constitution is fundamental for understanding this relationship. Here, we comprehensively describe the naturally presented HLA ligandome of colorectal carcinoma and corresponding nonmalignant colon (NMC) tissue. Mass spectrometry identified 35,367 and 28,132 HLA class I ligands on colorectal carcinoma and NMC, attributable to 7,684 and 6,312 distinct source proteins, respectively. Cancer-exclusive peptides were assessed on source protein level using the Kyoto Encyclopedia of Genes and Genomes (KEGG) and protein analysis through evolutionary relationships (PANTHER), revealing pathognomonic colorectal carcinoma-associated pathways, including Wnt, TGFβ, PI3K, p53, and RTK-RAS. Relative quantitation of peptide presentation on paired colorectal carcinoma and NMC tissue further identified source proteins from cancer- and infection-associated pathways to be overrepresented merely within the colorectal carcinoma ligandome. From the pool of tumor-exclusive peptides, a selected HLA-ligand subset was assessed for immunogenicity, with the majority exhibiting an existing T-cell repertoire. Overall, these data show that the HLA ligandome reflects cancer-associated pathways implicated in colorectal carcinoma oncogenesis, suggesting that alterations in tumor cell metabolism could result in cancer-specific, albeit not mutation-derived, tumor antigens. Hence, a defined pool of unique tumor peptides, attributable to complex cellular alterations that are exclusive to malignant cells, might comprise promising candidates for immunotherapeutic applications.<b>Significance:</b> Cancer-associated pathways are reflected in the antigenic landscape of colorectal cancer, suggesting that tumor-specific antigens do not necessarily have to be mutation-derived but may also originate from other alterations in cancer cells. <i>Cancer Res; 78(16); 4627-41. ©2018 AACR</i>.
Adhesion properties and phase separation behavior of glycidyl‐terminated polyurethanes (1994)

Abstract 2,3‐Epoxy‐1‐propanol has been introduced into isocyanate‐terminated polyurethane to form glycidyl‐terminated polyurethane resins. A series of glycidyl‐terminated polyurethanes based on hydroxyterminated poly(oxypropylene) (poly(oxypropylene) glycol, PPG), toluene diisocyanate (TDI), and 1,4‐butanediol (BD) was synthesized with various PPG soft segment lengths (MW 700, 1000 and 2000) and soft segment concentrations (30, 50 and 70 wt.‐%). The effects of glycidyl‐terminated polyurethane on the adhesion properties and the phase separation were investigated. The adhision properties at liquid nitrogen temperature coincide with the phenomenon observed in the phase separation behavior of polyurethane. Differential scanning calorimetry (DSC) and infrared technique (IR) were used to assess the phase separation content. The enthalpy jump at the glass transition temperature (ΔC p ) and the unique spectroscopic features in the NH and CO stretching regions were applied to characterized the phase separation behavior. It was found that the modified resins do not only show superior adhesion at liquid nitrogen temperature but also exhibit some unique properties, e.g., room temperature curing and good storage stability.
Asymptomatic Reactivation of Herpes Simplex Virus in Women after the First Episode of Genital Herpes (1992)

Asymptomatic genital herpes simplex type 2 is more common than type 1. Asymptomatic genital shedding occurs more often during the first 3 months after acquisition of primary type 2 disease than during later periods. Patients with HSV type 2 should be advised of this high early rate of asymptomatic shedding and of potential transmission to sexual partners.
High performance `Drop and Continue' functionality in a Wavelength Selective Switch (2006)

We demonstrate for the first time channel-selective optical power sharing between a designated express-port and any drop-port of a 1×9 50 Channel WSS. Bit-Error Rate testing shows that this drop- and-continue functionality can be implemented with negligible system penalty.
A 1.9 GHz CMOS Power Amplifier With Embedded Linearizer to Compensate AM-PM Distortion (2012)

A series combining transformer(SCT)-based, watt-level 1.9 GHz linear CMOS power amplifier with an on-chip linearizer is demonstrated. Proposed compact, predistortion-based linearizer is embedded in the two-stage PA to compensate AM-PM distortion of the cascode power stages, and improve ACLR of 3GPP WCDMA uplink signal by 2.6 dB at 28.0 dBm output power. The designed interstage power distributor with one tuning inductor contributes to low-loss power supply for the driver stage and high common-mode stability of the whole PA. Moreover, a newly developed PVT variation- tolerant cascode biasing circuit guarantees highly accurate bias voltages in a wide supply voltage range from 2.5 V to 3.6 V. The test chip demonstrates maximum output power of 28.3 dBm at 1.95 GHz, satisfying 3GPP WCDMA spectrum mask with die area of 5.4 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
GLYCOGEN SYNTHASE KINASE-3 FROM RABBIT SKELETAL MUSCLE (1981)

Conference Abstract| April 01 1981 GLYCOGEN SYNTHASE KINASE-3 FROM RABBIT SKELETAL MUSCLE Brian A. Hemminqs; Brian A. Hemminqs 1Department of Biochemistry, University of Dundee, Dundee DD1 4HN, Scotland Search for other works by this author on: This Site PubMed Google Scholar David Yellowlees; David Yellowlees 1Department of Biochemistry, University of Dundee, Dundee DD1 4HN, Scotland Search for other works by this author on: This Site PubMed Google Scholar Philip Cohen Philip Cohen 1Department of Biochemistry, University of Dundee, Dundee DD1 4HN, Scotland Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1981) 9 (2): 241P. https://doi.org/10.1042/bst009241pa Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation Brian A. Hemminqs, David Yellowlees, Philip Cohen; GLYCOGEN SYNTHASE KINASE-3 FROM RABBIT SKELETAL MUSCLE. Biochem Soc Trans 1 April 1981; 9 (2): 241P. doi: https://doi.org/10.1042/bst009241pa Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1981 Biochemical Society1981 Article PDF first page preview Close Modal You do not currently have access to this content.
Tomographic PIV measurement of flow in a complex geometry of nasal cavity (2013)

Flow inside a scaled model of nasal cavity was measured by tomographic PIV. The model was constructed with transparent silicon. A refractive index of working fluid was matched to the model index by mixing glycerol and water. Four cameras and double pulse laser system were used for tomographic PIV. To obtain high SNR, red fluorescence particles and longpass glass filters were used. A complex model shape was estimated by accumulating three-dimensional particle positions obtained by least square based triangulation. Morphological operations such as opening and closing were used to improve the estimation quality. The geometry information was used to distinguish the fluid and solid regions in the tomographic reconstruction procedure. The model estimation and tomographic reconstruction procedures were evaluated by synthetic image test. The synthetic images were generated by placing a computer model (stereolithography file from CT data) to a virtual 3D coordinates and by seeding particles in the flow region randomly. Perspective transformation matrix for synthetic image generation was adopted from the experimental camera matrix. The synthetic image test shows that the reconstruction quality for a complex 3D geometry was improved by a masking technique. Finally, flow velocity field was calculated from 3D cross-correlation of reconstructed voxel intensities.
Antagonism of central melanin-concentrating hormone 1 receptor alleviates steatohepatitis in mice (2008)

Blockade of brain melanin-concentrating hormone 1 receptor (MCH1R) significantly ameliorates fatty liver as well as obesity. However, the mode of action of this effect is unknown. This study examined the effect of a MCH1R antagonist in murine steatohepatitis models with and without obesity and clarified whether these pharmacological effects were attributed to anti-obesity effects. Steatohepatitis with concomitant obese phenotypes was developed after 52-week exposure to a high-fat diet, and steatohepatitis with reduced body weight was developed by exposure to a methionine- and choline-deficient diet for 10 days. Chronic intracerebroventricular infusion of a peptidic MCH1R antagonist reduced hepatic triglyceride contents and ameliorated steatohepatitis on histological observations in both mice models. Improvement of steatohepatitis was concomitant with amelioration of obese phenotypes such as hyperinsulinemia and hyperleptinemia in the case of the obese model, whereas body weight reduction was not associated with amelioration of steatohepatitis by the antagonist in the lean model. Reduction of hepatic gene expressions encoding cytochromes P450 4A was identified by treatment with the antagonist in both the obese and lean models. These results suggest that brain blockade of MCH1R could alleviate steatohepatitis independently from anti-obesity effects. In conclusion, MCH1R antagonist could have a new therapeutic potential for the treatment of human nonalcoholic steatohepatitis.
Noise-Enhanced Multistability in Coupled Oscillator Systems (1997)

We study nonequilibrium phenomena in a globally coupled oscillator system with a third harmonic pinning force in the presence of an additive noise and a fluctuating interaction. The system shows a subcritical saddle-node bifurcation from an asymmetric state to a symmetric state at a critical noise intensity leading to multistable states. The fluctuating interaction increases the critical noise intensity and thus enhances the multistability drastically. We show phase diagrams and discuss the nature of the phase transition.
Metamorphic Channels in Periodic Mesoporous Methylenesilica (2000)

Bridging methylene groups are transformed into terminal methyl groups when periodic mesoporous methylenesilicas, prepared for the first time by surfactant-templated synthesis, are subjected to controlled thermal treatment at 350–600°C. The methylene groups integrated “inside the channel walls” transform smoothly to methyl groups suspended “within the channel spaces” (shown schematically).
Influence of Mir-155 On B-Cell Receptor Signaling in Chronic Lymphocytic Leukemia. (2009)

Abstract Abstract 2343 Poster Board II-320 B-cell receptor (BCR) signaling arguably plays an important role in the pathogenesis and/or progression of chronic lymphocytic leukemia. Ligation of the BCR by F(ab)2 anti-μ can induce phosphorylation of p72Syk, BLNK, phospholipase C-gamma (PLCγ) and other downstream adapter/signaling molecules, inducing intracellular calcium flux and cellular activation. Prior studies found that CLL cells that expressed unmutated Ig heavy-chain variable region genes (IGHV) and the zeta-associated protein of 70 kD (ZAP-70) generally experienced greater levels of activation following treatment with anti-μ than did CLL cells that lacked expression of ZAP-70. However, we found unusual cases that lacked expression of ZAP-70 that also responded vigorously to treatment with anti-μ, suggesting that other factors contribute to the noted differences in BCR-signaling. Analyses for expression of microRNAs by microarray revealed that CLL cells that used unmutated IGHV and that expressed ZAP-70 expressed higher levels of certain microRNAs than did cases that used mutated IGHV and that lacked expression of ZAP-70. One of such microRNA, miR-155, was found to target mRNA encoding SHIP-1, a phosphatase that plays a critical role in modulating the level of BCR signaling in normal B cells. Using quantitative assays for miR-155 we found high-level expression of this microRNA was associated with proficient BCR signaling in CLL. To examine whether miR-155 could modulate the levels of SHIP-1 and/or BCR signaling in CLL cells we transfected primary leukemia cells from each of multiple patients with control oligo-RNAs, miR-155, or a specific inhibitor of miR-155 (miR-155 inhibitor). Twenty-four hours later the cells were stimulated with anti-μ or control antibody and then examined 10 minutes later for expression of SHIP-1, induced calcium influx, or phosphorylation of kinases and adapter proteins that are involved in BCR signaling. CLL cells that had low expression levels of miR-155 and that were poorly responsive BCR had significantly higher levels of calcium influx and phosphorylated p72Syk, BLNK, and PLCγ in response to anti-μ following transfection with miR-155 than following mock transfection or transfection with control oligo-RNA. Conversely, CLL cells that had high expression levels of miR-155 and highly responsive BCR were made to have significantly higher amounts of SHIP-1 protein and to have significantly lower relative levels of phosphorylated protein and calcium influx in response to anti-μ following transfection with the miR-155 inhibitor than did mock transfected CLL cells. These results identify miR-155 as a factor that can modulate BCR signaling in CLL in part by regulating the relative expression level of SHIP-1. These results demonstrate that differential expression of microRNAs in CLL can influence physiologic features that potentially contribute to disease progression. Disclosures: No relevant conflicts of interest to declare.
Large Self‐Assembled Chiral Organic Cages: Synthesis, Structure, and Shape Persistence (2011)

Keep the cage filled: Two large organic cages (see example) with void diameters of 1.2 nm were synthesized through [8+12] imine condensation reactions. The materials become amorphous upon solvent removal and show little permanent porosity. Molecular dynamics simulations give an insight into the mechanism of these processes, suggesting strategies for synthesizing larger shape-persistent organic cages in the future. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Escherichia coliK1 Capsular Polysaccharide Associated with Neonatal Meningitis (1974)

Examination of 77 strains of Escherichia coli from the cerebrospinal fluid of neonates with meningitis revealed 65 (84 per cent) with the capsular (K1) polysaccharide. The Esch. coli K1 capsular antigen has been shown to be immunochemically identical to the meningococcal Group B polysaccharide. These cerebrospinal-fluid Esch. coli K1 strains were associated with at least seven different somatic (O) and three flagella (H) antigens. In contrast, Esch. coli K1 strains were found in 14 of 36 (39 per cent) blood cultures of neonates without meningitis and in approximately 15 per cent of blood, urine and stool cultures from adults and rectal cultures from infants. The mean median lethal dose in a mucin-enhanced mouse model for 31 neonatal cerebrospinal-fluid K1 isolates was 168 organisms. In contrast, the median lethal dose for 10 neonatal non-K1 isolates was 58,000 and was greater than 10,000 organisms for six non-K1 enteropathogenic strains and five K1 strains isolated from normal infant stools. The high prevalence of the K1 antigen in neonatal meningitis suggests that this capsular polysaccharide is related to Esch. coli invasiveness in the newborn. A protective effect of anti-capsular antibody in a mouse model suggests that immunity to neonatal Esch. coli K1 meningitis may be mediated by serum antibodies. (N Engl J Med 290:1216–1220, 1974)
Comparison of Artificial Life Techniques for Market Simulation (2006)

Electricity industries worldwide are undergoing a period of profound upheaval. Conventional vertically integrated mechanism is replaced by a competitive market environment. A pure operating cost optimization is not enough to model the distributed, large-scale complex system. A market simulator will be a valuable training and evaluation tool to assist sellers, buyers & regulators to understand system’s dynamic performance and make better decisions avoiding bunch of risks. The objective of this research is to model market players by adaptive multi-agent system, compare the performances of different artificial life technique such as Genetic Algorithm (GA), Evolutionary Programming (EP) and Particle Swarm (PS) in simulating players’ behaviors, identify the best method to emulates real rational participants.
Modelling Surround‐aware Contrast Sensitivity for HDR Displays (2022)

Abstract Despite advances in display technology, many existing applications rely on psychophysical datasets of human perception gathered using older, sometimes outdated displays. As a result, there exists the underlying assumption that such measurements can be carried over to the new viewing conditions of more modern technology. We have conducted a series of psychophysical experiments to explore contrast sensitivity using a state‐of‐the‐art HDR display, taking into account not only the spatial frequency and luminance of the stimuli but also their surrounding luminance levels. From our data, we have derived a novel surround‐aware contrast sensitivity function (CSF), which predicts human contrast sensitivity more accurately. We additionally provide a practical version that retains the benefits of our full model, while enabling easy backward compatibility and consistently producing good results across many existing applications that make use of CSF models. We show examples of effective HDR video compression using a transfer function derived from our CSF, tone‐mapping and improved accuracy in visual difference prediction.
A simple, robust and highly efficient transient expression system for producing antibodies (2013)

Transient expression systems in mammalian cells have become the method of choice for producing research quantities of antibodies. Both the speed and yield of the available transient systems and the natural posttranslational modifications favor these systems above expression in lower eukaryotes, prokaryotes or stable cell lines. We describe an optimized mammalian transient expression system, capable of producing up to 400mg/L of native secreted antibodies in less than a week. The system is composed of commercially available components and is based on expression in the fast growing suspension cell line, FreeStyle™ 293-F (HEK-293F). The method depends on an optimal combination of a gene transfer method, an expression vector and cotransfection with expression enhancing plasmids, encoding the large T antigen of the SV40 virus and the cell cycle inhibitors p21 and p27. Optimization of all components of the expression system, by experimental design techniques, yielded maximal expression levels (including antibody isotypes IgG1, 2, 3, 4 and Fab fragments of various species). Expression volumes were scalable from 0.1 ml up to 1.2L in a simple shaker flask system in animal component free, low protein medium, enabling consistent production of relatively high amounts of a large number of native antibodies.
Experimental Evaluation on SU-MIMO Transmission with Closed-Loop Precoding in LTE-Advanced Uplink (2011)

This paper presents the laboratory experimental results employing LTE-Advanced testbed for the evaluation of the throughput performance of closed-loop single-user MIMO transmission at the uplink single carrier (SC)-FDMA radio access in LTE-Advanced. The throughput evaluation includes the impact of estimation accuracy of MIMO channel responses which are derived from the sounding reference signal (SRS) and used for the precoding vector (PV) selection and adaptive modulation and coding (AMC) at the base station. The experimental results elucidate that the maximum throughput of 200 Mbps is achieved in multipath fading environments by using 2-by-2 spatial multiplexing and carrier aggregation with 2 component carriers. The results also clarifies that the estimation accuracy of MIMO channel responses using the SRS has a greater influence on modulation and coding scheme (MCS) selection for AMC than PV selection due to the fact that the throughput performance employing AMC is clearly degraded by approximately 20% while the block error rate for Rank-1 closed-loop transmit diversity is not degraded very much when the transmission power ratio of SRS to data channel is reduced from 0 dB to -10 dB.
Signal Conditioning (2009)

No AccessPlastics Manufacturing Systems EngineeringJun 2009Signal ConditioningDavid O. KazmerDavid O. KazmerSearch for more papers by this authorhttps://doi.org/10.3139/9783446430143.007SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2009Pages: 189-231Print ISBN: 978-3-446-42014-4eISBN: 978-3-446-43014-3 Copyright & Permissions© 2009 Carl Hanser Verlag GmbH & Co. KGPDF DownloadLoading ...