gebhart/patrepeval huggingface dataset:
Innovating and adapting in pediatric pulmonology and sleep medicine during the COVID‐19 pandemic: ATS pediatric assembly web committee consensus statement for initial COVID‐19 virtual response (2020)

Coronavirus disease 2019 (COVID-19) has been an unprecedented and continuously evolving healthcare crisis. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) spread rapidly and initially little was known about the virus or the clinical course for infected children. In the United States of America, the medical response has been regionalized, based on variation in community transmission of the virus and localized outbreaks. Pediatric pulmonary and sleep divisions evolved in response to administrative and clinical challenges. As the workforce transitioned to working remotely, video conferencing technology and multicenter collaborative efforts were implemented to create clinical protocols. The COVID-19 pandemic challenges the framework of current medical practice but also highlights the dynamic and cooperative nature of pediatric pulmonology and sleep medicine. Our response to this pandemic has laid the groundwork for future challenges.
Silver and palladium nanoparticles-containing products of the low-temperature wave conversion of an energetic material: Catalytic activity in piperylene hydrogenation (2011)

The hydrogenation of 1,3-pentadiene into pentenes over the commercial 0.5% Pd/Al2O3 catalyst and over a new catalyst containing 1.0% Pd and 3.7% Ag (μ-catalyst) has been investigated. The new catalyst has been prepared via the flameless wave conversion of cyclotrimethylenetrinitramine in a porous composite. The catalytic properties of the new composite in the hydrogenation reaction depend on the hydrogen/1,3-pentadiene ratio and on the catalyst activation temperature. The reaction conditions for selective 1,3-pentadiene hydrogenation have been optimized. The pentenes yield as a function of temperature passes through a maximum at any H2/C5H8 ratio between 1 and 2. The 2-pentene/1-pentene ratio in the reaction products increases as the temperature is raised.
Multi-protein assemblies underlie the mesoscale organization of the plasma membrane. (2014)

Most proteins have uneven distributions in the plasma membrane. Broadly speaking, this may be caused by mechanisms specific to each protein, or may be a consequence of a general pattern that affects the distribution of all membrane proteins. The latter hypothesis has been difficult to test in the past. Here, we introduce several approaches based on click chemistry, through which we study the distribution of membrane proteins in living cells, as well as in membrane sheets. We found that the plasma membrane proteins form multi-protein assemblies that are long lived (minutes), and in which protein diffusion is restricted. The formation of the assemblies is dependent on cholesterol. They are separated and anchored by the actin cytoskeleton. Specific proteins are preferentially located in different regions of the assemblies, from their cores to their edges. We conclude that the assemblies constitute a basic mesoscale feature of the membrane, which affects the patterning of most membrane proteins, and possibly also their activity.
Smart solutions for intermittent supply systems (2020)

Intermittent operation of water supply networks is widespread, including in sub-Saharan Africa. Edo Abraham, Joost Verbart and Jan Peter van der Hoek look at the opportunities to use digital technologies to improve management.
OBESITY AND GLUCOSE INTOLERANCE ARE ASSOCIATED WITH DIASTOLIC DYSFUNCTION: EXPOSING THE ACHILLES HEEL OF EARLY DIABETIC CARDIOMYOPATHY. (2007)

Background The alarming rise in the incidence of obesity has paralleled the surge in the incidence of impaired glucose tolerance (prediabetes) and overt diabetes. The cardiovascular sequelae of insulin resistance are thought to occur later, along with the development of atherosclerotic coronary artery disease. Yet emerging evidence suggesting early organ dysfunction in insulin resistance (such as nonalcoholic steatohepatitis) points to an early visceral ectopic fat deposition referred to as lipotoxicity. We sought to evaluate the effects of insulin resistance and impaired glucose tolerance on cardiac function in otherwise healthy overweight volunteers. Methods Twenty healthy obese and overweight volunteers (mean age 42 ± 6 years; 15 females) underwent glucose tolerance testing, direct insulin measurements, as well as dual x-ray absorptiometry (DXA, to assess subcutaneous and visceral fat mass). The cardiac evaluation included complete two-dimensional, Doppler, and tissue velocity imaging (TVI). The postprocessing of the TVI data was performed on an EchoPac work station (GE Health Systems) and the data were analyzed using Pearson correlation model and unpaired Student9s t-test. Results The mean weight of the subjects was 90 ± 12 kg, mean BMI of 32 ± 4 kg/m2, and mean systolic BP of 127 ± 15. The mean fasting blood glucose levels was 91 ± 13 with a mean HbA1C of 5.7 ± 0.4. The peak diastolic strain rate showed a significant inverse relationship with subcutaneous fat mass as well as fasting and 2-hour blood glucose levels (r = .54, p Conclusion Diastolic dysfunction occurs early in the course of obesity and glucose intolerance and may be a precursor of overt diabetic cardiomyopathy.
Utilizing a Simple Method for Stoichiometric Protein Labeling to Quantify Antibody Blockade (2019)

Ligand binding assays routinely employ fluorescently-labeled protein ligands to quantify the extent of binding. These ligands are commonly generated through chemical modification of accessible lysine residues, which often results in heterogeneous populations exhibiting variable binding properties. This could be remedied by quantitative, site-specific labeling. Recently, we reported on a single-step method integrating recombinant protein purification with 2-cyanobenzothiazole (CBT) condensation for labeling a proteolytically exposed N-terminal cysteine. Here, using three growth factors, we show that unlike random lysine labeling, this site-specific approach yielded homogeneous populations of growth factors that were quantitatively labeled at their N-termini and retained their binding characteristics. We demonstrate the utility of this labeling method through the development of a novel assay that quantifies the capacity of antibodies to block receptor-ligand interactions (i.e. antibody blockade). The assay uses bioluminescence resonance energy transfer (BRET) to detect binding of CBT-labeled growth factors to their cognate receptors genetically fused to NanoLuc luciferase. The ability of antibodies to block these interactions is quantified through decrease in BRET. Using several antibodies, we show that the assay provides reliable quantification of antibody blockade in a cellular context. As demonstrated here, this simple method for generating uniformly-labeled proteins has potential to promote more accurate and robust ligand binding assays.
Hydrothermal Synthesis of Nanoclusters of ZnS Comprised on Nanowires (2013)

Cetyltrimethyl ammonium bromide cationic (CTAB) surfactant was used as template for the synthesis of nanoclusters of ZnS composed of nanowires, by hydrothermal method. The structural and morphological studies were performed by using X-ray diffraction (XRD), scanning electron microscopy (SEM) and high resolution transmission electron microscopy (HRTEM) techniques. The synthesized ZnS nanoclusters are composed of nanowires and high yield on the substrate was observed. The ZnS nanocrystalline consists of hexagonal phase and polycrystalline in nature. The chemical composition of ZnS nanoclusters composed of nanowires was studied by X-ray photo electron microscopy (XPS). This investigation has shown that the ZnS nanoclusters are composed of Zn and S atoms.
Noise reduction using an adaptive microphone array in a car-a speech recognition evaluation (2002)

This paper describes an evaluation of an adaptive microphone array with respect to speech recognition performance in a car. The microphone array is compared to two conventional microphones of different types. The speech recognition device is aimed to be a part of a man/machine-interface between the driver and car information services.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Multi-gigabit traffic identification on GPU (2013)

Traffic Identification is a crucial task performed by ISP administrators to evaluate and improve network service quality. Deep Packet Inspection (DPI) is a well-known technique used to identify networked traffic. DPI relies mostly on Regular Expressions (REs) evaluated by Finite Automata. Many previous studies have investigated the impacts on the classification accuracy of such systems when inspecting only a portion of the traffic. However, none have discussed the real impacts on the overall system throughput. This work presents a novel technique to perform DPI on Graphics Processing Units (GPU) called Flow-Based Traffic Identification (FBTI) and a proof-of-concept prototype analysis. Basically we want to increase DPI systems? performance on commodity platforms as well as their capacity to identify networked traffic on high speed links. By combining Deterministic Finite Automaton (DFA) for evaluating REs and flow-level packet sampling we achieve a raw performance of over 60 Gbps on GPUs. Our prototype solution could reach a real throughput of over 12 Gbps, measured as the identified volume of flows.
An inhibitor of O-glycosylation induces apoptosis in NIH3T3 cells and developing mouse embryonic mandibular tissues. VOLUME 279 (2004) PAGES 50382-50390 (2008)

An Inhibitor of O-Glycosylation Induces Apoptosis in NIH3T3 Cells and Developing Mouse Embryonic Mandibular TissuesJournal of Biological ChemistryVol. 279Issue 48PreviewThe family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases (ppGaNTases) is responsible for initiating mucin-type O-linked glycosylation in higher eukaryotes. To begin to examine the biological role of O-linked glycosylation, mammalian cells were treated with a small molecule inhibitor (designated 1–68A, Ref. 15) of ppGaNTase activity. NIH3T3 cells exposed to the inhibitor were shown to undergo a significant reduction in cell surface O-glycosylation as detected by staining with jacalin and peanut agglutinin lectins after 30 min of treatment; no reduction in staining using antibodies to O-linked N-acetylglucosamine or the lectin concanavalin A was detected. Full-Text PDF Open Access 50382-50390 This article has been withdrawn by the authors for the following reasons. In this work, we employed a small molecule (designated 1-68A) that is an inhibitor of the UDP-GalNAc polypeptide:N-acetylgalactosaminyltransferases to probe the functions of O-glycosylation. Follow-up work by our laboratories indicates that this compound (1-68A) is not stable under the cell culture conditions used in this work; it decomposes by an oxidative mechanism that has not yet been fully elucidated, producing H2O2 in the process. The compound is unstable at physiological pH (decomposing in phosphate-buffered saline, pH 7.4, or either RPMI 1640 or F-12 medium) and is stable at acidic pH (phosphate-buffered saline, pH 4.5). We have since demonstrated that H2O2 can induce cell death in several cell lines, including NIH3T3 cells, under the conditions used in this work. Thus, although we have confirmed that the central observations reported are accurate, we can no longer attribute the finding of apoptosis to inhibition of O-glycosylation per se. To avoid any future ambiguity about these findings, we withdraw the publication.
Physiological Changes during Recovery from a Primate Dorsal Column Lesion (1994)

The evoked potential (EP) over primary somatosensory cortex (SI) was monitored before and after a complete lesion of the primate dorsal column (DC) pathway on one side. The EP was elicited by electrocutaneous or mechanical stimulation of either foot, and was recorded from the contralateral cortical surface for periods of up to 3 months after the lesion. The amplitudes of the three major peaks (P20, N50, and P90) of the cortical somatosensory EP were significantly reduced following interruption of the contralateral DC. Over weeks following the lesion, there was a significant increase in amplitude of the P90 component of the EP that was not evident in the other peaks. The postlesion increases in P90 amplitude were correlated with improved performance on a task that required grasping with either foot, suggesting that behavioral recovery from a DC lesion results in part from neural plasticity, as opposed to a simple relearning of the task.
Sleeve rotor synchronous reluctance electric machine (2023)

According to various embodiments, a synchronous reluctance machine is disclosed. The synchronous reluctance machine includes a stator, a synchronous reluctance rotor disposed within the stator and configured to rotate relative to the stator, and a non-magnetic sleeve disposed circumferentially around the rotor, where sleeve thickness is between about 1 mm and 2 mm and an air-gap radius is between about 80 mm and 100 mm.
Demonstration of 108 Gb/s Duo-Binary PAM-8 Transmission and the Probabilistic Modeling of DB-PAM-M BER (2021)

We report 108 Gb/s Duo-Binary PAM-8 (DB-PAM-8) transmission using direct-detection aided by Volterra equalizer. The bit-error-rate (BER) performance of the DB-PAM-8 signal has been evaluated through error counting by varying the bit rate, received optical power, and reach. The experimental results suggest that up to 108, 102, and 84 Gb/s signals can be propagated in back-to-back (B2B), and over 10, and 20 km of standard single-mode fiber (SMF), respectively, below the low-density parity-check forward error correction (LDPC-FEC) threshold. Furthermore, we derive a probabilistic model of the BER for multilevel DB-PAM-M signaling that is verified using our measurements. The model of this important performance metric turned out to be accurate enough, especially at low BER values, where its use is more convenient.
Attacking the problem of scalability in parallel Gauss-Seidel and Jacobi solvers for mixed model equations (1999)

The history of the CEBUS project and some of its early experiences was described in: “The CEBUS project: History and overview” by Larsen and Madsen (This workshop). Test of the second implementation showed that parallel speedup could be achieved, but communication among the processors could limit the parallel speedup substantially. An analysis of amount and pattern of communication indicates that it should be possible to reduce communication at the expense of a little more computation. This is achieved in a third implementation by splitting the MMEs in a local and a global subset, as described below. Common to all tree implementations are the following: To obtain data parallelism (DP), records are sorted according to level codes of one of the effects in the model. Typically effects as herd-year-season or management group is used to obtain DP. Initially the master processor distributes disjoint sets of records to the slave processors. In the same pass through data, diagonal blocks for all effects except the one used to obtain DP are built, inverted and stored. In every round of iteration, each slave processor processes its part of the data, solve for the DP effect by Gauss-Seidel and accumulate contributions to the corrected right hand sides for all other effects in a local vector. When all data has been processed a complete corrected right hand side (crhs) can be build by summing over processors. In the first two implementations a global reduce operation was used to obtain the global crhs. In the third implementation only a small subset of the global crhs is needed. Each processor then solves for a part of the remaining effects by second order Jacobi. The third implementation is characterised by a split of the system in equations within a processor (local equations) and equations across processors (global equations). The local equations only receive contributions from data on the processor in question, while the global equations receive contributions from data on more than one processor. This approach has been programmed, and test runs on models of dimensions between 1.2 and 30.1 mio. equations has shown close to linear scalability and in some cases super linear scalability.
Alignment Using Variable Penalty Dynamic Time Warping (2009)

In this article we highlight a novel variation on dynamic time warping (DTW) for aligning chromatogram signals. We are interested in sets of signals that can be aligned well locally, but not globally, by shifting individual signals in time. This kind of alignment is often sufficient for aligning gas chromatography data. Regular DTW often "over-warps" signals and introduces artificial features into the aligned data. To overcome this we introduce a variable penalty into the DTW process. The penalty is added to the distance metric whenever a nondiagonal step is taken. We select our penalty based on a morphological dilation of the two signals. We showcase our method by aligning GC/MS datafiles from 712 blood plasma samples processed in 23 batches over the course of 6 months. The use of variable penalty DTW significantly reduces the number of nondiagonal moves. In the examples presented here, this reduction is by a factor of 30, with no cost to visual quality of the alignment.
C223 Development of laser peening technology for low pressure turbine blades : The result of fatigue-characteristics evaluation of 12Cr steel, and system equipment application (2010)

Some fatigue damages were found at the forks of low pressure turbine blades caused by random vibration and steam-flashback vibration. In this study, laser peening technology for 12Cr stainless steel was developed and the improvement of fatigue property was examined. As the results, the fatigue strength of laser peened specimens was improved about 40 percent compared to that of the unpeened specimens. A laser peening equipment was developed which could handle and peen the turbine blades successively.
Multilayer Polymer Optical Backplanes for Frequency Multiplexed Phase Fluorometry Arrays (2007)

Fluorescence detection with dense sensor arrays is realized in a multilayer large core polymer waveguide optical backplane. The multilayer backplane employs optical vias combined with frequency domain multiplexing to facilitate 4:1 multiplexing in the readout.
Intrablastocyst injection with human CD34+/CD133+ cells increase survival of immunocompetent fumarylacetoacetate hydrolase knockout mice (2012)

Mice harbouring a humanized liver represent a powerful tool for translating preclinical studies of drug metabolism and pharmacokinetics into humans, as well as the exploitation of basic studies on liver pathophysiology including hepatitis C virus (HCV) infection. Human adult stem cells injected into immunocompetent mice at preimmune stages of development, generate chimeric animals harbouring a liver with relatively discrete foci of human hepatocyte-like cells. In this study, we have evaluated whether similar protocol of xenotransplantation in the presence of selective pressure might lead to a higher human-into-mouse liver repopulation, leading to a relevant improvement of liver function. Human CD34(+)/CD133(+) cells were microinjected into blastocysts from genetically-modified mice committed to develop a lethal hepatopathy, due to the absence of the enzyme fumarylacetoacetate hydrolase (FAH). Following xenotransplantation, mouse survival was followed over time and histochemical evidence of liver chimerism was assessed. The survival expectancy of seven out of 21 intrablastocyst xenotransplanted FAH knockout (Fah-/-) mice was significantly higher as compared with non-xenotransplanted mice. Several nodules of human hepatocyte-like cells were revealed by immunohistochemistry in the liver of rescued mice. Our data positively support the hypothesis that preimmune xenotransplantation of human stem cells into immunocompetent mice harbouring a lethal hepatic disease might lead to a functionally relevant human-mouse liver chimerism and marks a significant advancement towards the establishment of a novel translational preclinical model for liver diseases.
Platelets support pulmonary recruitment of neutrophils in abdominal sepsis* (2009)

These data demonstrate that platelets play a key role in regulating infiltration of neutrophils and edema formation in the lung via upregulation of Mac-1 in abdominal sepsis.
A 60-GHz Transceiver and Baseband With Polarization MIMO in 28-nm CMOS (2018)

Polarization (pol) selectivity has been widely adopted in modern RF transceivers to enable the channel diversity. This paper utilizes orthogonal pol modes to support simultaneous independent data streams on the same frequency channel, thereby doubling the effective channel capacity. The energy-efficient 60-GHz transceiver prototype uses two transmit/receive (TX/RX) chains with a single printed circuit board (PCB) antenna to demonstrate over-the-air (OTA) 2 × 13.9 Gb/s 16 quadrature-amplitude modulation (QAM) dual-pol (DP) multiplexing-based multi-input and multi-output (MIMO), thus achieving 2× higher communicated bits/symbol than a single-pol transceiver. At these multi-Gb/s rates, multi-path ISI and cross-pol effects limit the feasibility of DP-MIMO. To mitigate these channel effects, a mixed-signal 384-coefficient feed-forward equalizer (FFE)- and 2400-coefficient decision-feedback equalizer (DFE)-based areaand energy-efficient RX baseband is also presented. The baseband supports DP-MIMO up to 40 Gb/s for line-of-sight (LOS) 16QAM and 14 Gb/s non-line-of-sight (NLOS) QPSK, at 3× to 38× better energy efficiency per coefficient than state of the art.
Insulin resistance and macrovascular disease (1996)

Controversy continues as to whether insulin resistance and hyperinsulinemia are risk factors for coronary artery disease. Ethnicity and the presence of other risk factors for atherosclerosis likely govern this relationship, so that the presence of components of the insulin resistance syndrome predispose subjects to coronary artery disease. Insulin itself has effects on the vasculature that may both promote and prevent the atherosclerotic process. An imbalance of these effects, possibly due to insulin resistance in the vasculature, may enhance atherosclerosis.
Specific Antitumor Targetable β-Cyclodextrin−Poly(ethylene Glycol)−Folic Acid Drug Delivery Bioconjugate (2004)

The tumor targeting properties of a new drug carrier synthesized by bioconjugation of folic acid (FA) to beta-cyclodextrins through a poly(ethylene glycol) (PEG) spacer (CD-PEG-FA) were investigated. Surface plasmon resonance demonstrated that CD-PEG-FA specifically interacts with immobilized folate binding protein (FBP) while the naked beta-cyclodextrins do not display any specific interaction. In vitro studies demonstrated that CD-PEG-FA was devoid of cell toxicity. [(3)H]-folic acid/CD-PEG-FA competition binding investigations performed with folate receptor overexpressing human epidermal carcinoma KB cells showed that CD-PEG-FA had about 14 times lower tumor cell binding capacity than free folic acid. The carrier cell trafficking properties were investigated using rhodamine-B as fluorescent probe, which possesses 3000 and 4580 M(-)(1) inclusion constants for CD-PEG-FA and beta-cyclodextrins, respectively. Cell-associated fluorescence measurements showed that CD-PEG-FA does not promote the rhodamine-B uptake into non-folate receptor expressing human lung carcinoma MCF7 cells while 19% higher accumulation in KB cells was found with respect to rhodamine-B loaded beta-cyclodextrins. Confocal laser scanning microscopy indicated the presence of cytosolic red fluorescent spots after 2 h of incubation of KB cells with rhodamine-B included CD-PEG-FA. The fluorescent dye resided primarily in small spots, namely, endosomes and multivesicular bodies. At 1 h after pulsed incubation, wider red fluorescent cellular structures appeared as a fusion of previous structures.