gebhart/patrepeval huggingface dataset:
Sensitivity Analysis of a Bolt-Together Vehicle Chassis (2006)

&lt;div class="htmlview paragraph"&gt;This study involves the investigation of the sensitivity of the torsional stiffness of a bolt-together heavy truck chassis to variations in tight/loose conditions for various combinations of individual bolts or groups of bolts. The behavior of the chassis, which features several hundred threaded fasteners as the primary means of connecting the cross members to the longitudinal beams, is studied using the Hierarchical Evolutionary Engineering Design System (HEEDS) in connection with the finite element program (ABAQUS) for performing a multiple-run analysis. A novel analysis approach involving a systematic segregation of the bolts is introduced.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;First, the bolts that are used for connecting the components of the chassis are divided into various sets. Each set represents a number of individual bolts in each joint between the longitudinal beams and the various cross members. In order to identify the relative significance of each joint location to the chassis torsional stiffness, the entire set of bolts in each joint is turned “on” or “off” to simulate whether the joint is tight or all loose, respectively. The effect of various permutations of tight and loose joints is investigated. Second, individual bolts are turned “on” or “off” within the identified critical joint(s) in order to simulate whether the individual bolts are tight or loose, respectively. In order to verify the numerical trends, an experiment focusing upon a simplified chassis is conducted.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Both numerical and experimental studies are carried out. For the chassis design considered in this study, those bolts oriented parallel (as opposed to perpendicular) to the chassis length most influence the torsional stiffness. Experimental results indicate that the amount of system contact gaps (a.k.a. “play”) tends to be more sensitive to those bolts oriented parallel to the chassis length than those bolts oriented perpendicular to the chassis length.&lt;/div&gt;
Analysis of Frozen Sections of Intraoperative Specimens Obtained at the Time of Reoperation After Hip or Knee Resection Arthroplasty for the Treatment of Infection* (1999)

A negative finding on intraoperative analysis of frozen sections has a high predictive value with regard to ruling out the presence of infection; however, the sensitivity of the test for the detection of persistent infection is poor.
A new plasma device operated in liquids for biological applications (2015)

An in-liquid plasma device has been suggested for the first time to achieve the practical biological applications of sterilization and gene transfection. The device generates planar plasma in liquids from nine via-holes, and produces hydroxyl radicals (OH radicals) in plasma. In the device design, 2D-FEM simulation was performed to determine the device parameters: the device size, 30×30 mm; via-hole diameter, 50 μm; distance between via-holes, 10 mm. It was found that impedance variation at each via-hole can be ignored, since the electric double layer on the device is formed and acts as an impedance buffer layer. Finally, we confirmed that OH radicals were produced and Escherichia coli (E. coli) bacteria were eradicated within 16 minutes.
Structural Requirements for Glycolipid Antigen Recognition by CD1b-Restricted T Cells (1997)

The human CD1b protein presents lipid antigens to T cells, but the molecular mechanism is unknown. Identification of mycobacterial glucose monomycolate (GMM) as a CD1b-presented glycolipid allowed determination of the structural requirements for its recognition by T cells. Presentation of GMM to CD1b-restricted T cells was not affected by substantial variations in its lipid tails, but was extremely sensitive to chemical alterations in its carbohydrate or other polar substituents. These findings support the view that the recently demonstrated hydrophobic CD1 groove binds the acyl chains of lipid antigens relatively nonspecifically, thereby positioning the hydrophilic components for highly specific interactions with T cell antigen receptors.
The Evolution of Pediatric Continuous Renal Replacement Therapy (2014)

The provision of continuous renal replacement therapies (CRRT) to small children has generally required the adaptation of adult machines and modified operational characteristics. CRRT prescription for younger and smaller children versus adults differs significantly due to problems concerning the extracorporeal blood volume, the need for circuit blood priming, and the adaptation of machines designed for adult-sized patients. Moreover, the provision of renal replacement therapy to infants and neonates presents a unique problem: no more than 10-15% of their blood volume should be removed by the extracorporeal circuit to prevent hypotension and anemia. In 2012, a dedicated machine, i.e. the Cardio-Renal, Pediatric Dialysis Emergency Machine (CARPEDIEM), was developed and launched the 'fitted era' for pediatric CRRT. In this review, we analyze how CRRT techniques have evolved for pediatric application and describe the first in vivo application of the CARPEDIEM for the safe and efficacious provision of CRRT to infants.
1294: Quantitative Expression of Muscarinic Receptors in Urothelium and Detrusor of Healthy and Neurogenic Human Bladder (2006)

You have accessJournal of UrologyDiscussed Poster, Tuesday, May 23, 2006, 1:00 - 4:00 pm1 Apr 20061294: Quantitative Expression of Muscarinic Receptors in Urothelium and Detrusor of Healthy and Neurogenic Human Bladder Shachi Tyagi, Naoki Yoshimura, Michael B. Chancellor, and Fernando De Miguel Shachi TyagiShachi Tyagi More articles by this author , Naoki YoshimuraNaoki Yoshimura More articles by this author , Michael B. ChancellorMichael B. Chancellor More articles by this author , and Fernando De MiguelFernando De Miguel More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)33507-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1294: Quantitative Expression of Muscarinic Receptors in Urothelium and Detrusor of Healthy and Neurogenic Human Bladder." The Journal of Urology, 175(4S), p. 417 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 417 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Shachi Tyagi More articles by this author Naoki Yoshimura More articles by this author Michael B. Chancellor More articles by this author Fernando De Miguel More articles by this author Expand All Advertisement PDF downloadLoading ...
Voreloxin Is an Anticancer Quinolone Derivative that Intercalates DNA and Poisons Topoisomerase II (2010)

As a first-in-class anticancer quinolone derivative, voreloxin is a toposiomerase II-targeting agent with a unique mechanistic signature. A detailed understanding of voreloxin's molecular mechanism, in combination with its evolving clinical profile, may advance our understanding of structure-activity relationships to develop safer and more effective topoisomerase II-targeted therapies for the treatment of cancer.
A New Floating-Probe for Measurement of Insulated Plasma Produced by Radio-Frequency Power (2012)

The paper provides a new probe method which enables us to measure parameters of plasmas produced in insulated vessel. In particular, the measurements of electron temperature and density are all made in floating condition of probe, so that there is no need to draw net current from plasma. The method is based on measurement of the functional relationship between the floating potential and the heating voltage of emissive probe. In the first place, the measured parameters of plasma produced in the metal vessel are shown, demonstrating how a new probe works. In the second place, the measurement in the quartz discharge tube is shown, and the measured data by the present method are compared with those obtained by the conventional double probe, demonstrating that they are consistent. It is emphasized that the present new method is a first success in floating probe to be able to measure all plasma parameters.
Characterization of in vitro antimurine thymocyte globulin–induced regulatory T cells that inhibit graft-versus-host disease in vivo (2007)

Antithymocyte/antilymphocyte globulins are polyclonal antihuman T-cell antibodies used clinically to treat acute transplant rejection. These reagents deplete T cells, but a rabbit antihuman thymocyte globulin has also been shown to induce regulatory T cells in vitro. To examine whether antithymocyte globulin-induced regulatory cells might be functional in vivo, we generated a corresponding rabbit antimurine thymocyte globulin (mATG) and tested its ability to induce regulatory cells in vitro and whether those cells can inhibit acute graft-versus-host disease (GVHD) in vivo upon adoptive transfer. In vitro, mATG induces a population of CD4(+)CD25(+) T cells that express several cell surface molecules representative of regulatory T cells. These cells do not express Foxp3 at either the protein or mRNA level, but do show suppressive function both in vitro and in vivo when adoptively transferred into a model of GVHD. These results demonstrate that in a murine system, antithymocyte globulin induces cells with suppressive activity that also function in vivo to protect against acute GVHD. Thus, in both murine and human systems, antithymocyte globulins not only deplete T cells, but also appear to generate regulatory cells. The in vitro generation of regulatory cells by anti-thymocyte globulins could provide ad-ditional therapeutic modalities for immune-mediated disease.
Non-Abelian geometric phases in ground-state Josephson devices (2010)

We present a superconducting circuit in which non-Abelian geometric transformations can be realized using an adiabatic parameter cycle. In contrast to previous proposals, we employ quantum evolution in the ground state. We propose an experiment in which the transition from non-Abelian to Abelian cycles can be observed by measuring the pumped charge as a function of the period of the cycle. Alternatively, the non-Abelian phase can be detected using a single-electron transistor working as a charge sensor.
Clinical and anatomic results of rotator cuff repair at 10 years depend on tear type (2018)

IV.
Synthetic, Chemically Defined Polymer‐Coated Microcarriers for the Expansion of Human Mesenchymal Stem Cells (2018)

Mesenchymal stem cells (MSC), also called marrow stromal cells, are adult cells that have attracted interest for their potential uses in therapeutic applications. There is a pressing need for scalable culture systems due to the large number of cells needed for clinical treatments. Here, a tailorable thin polymer coating-poly(poly(ethylene glycol) methyl ether methacrylate-ran-vinyl dimethyl azlactone-ran-glycidyl methacrylate) [P(PEGMEMA-r-VDM-r-GMA); PVG]-to the surface of commercially available polystyrene and glass microcarriers to create chemically defined surfaces for large-scale cell expansion is applied. These chemically defined microcarriers create a reproducible surface that does not rely on the adsorption of xenogenic serum proteins to mediate cell adhesion. Specifically, this coating method anchors PVG copolymer through ring opening nucleophilic attack by amine residues on poly-l-lysine that is pre-adsorbed to the surface of microcarriers. Importantly, this anchoring reaction preserves the monomer VDM reactivity for subsequent functionalization with an integrin-specific Arg-Gly-Asp peptide to enable cell adhesion and expansion via a one-step reaction in aqueous media. MSCs cultured on PVG-coated microcarriers achieve sixfold expansion-similar to the expansion achieved on PS microcarriers-and retain their ability to differentiate after harvesting.
Governance of Cross-Organizational Service Agreements: A Policy-Based Approach (2007)

Many real-life organizations are hierarchies of largely autonomous, heterogeneous members (individuals or other organizations), often exhibiting rich policies. We restrict our attention to organizations that monitor their environment, collate events, determine compliance of their behaviors with their policies, and potentially act in anticipation of events to ensure the satisfaction of their policies. This paper models cross-organizational service agreements as resulting in the formation of organizations. This paper emphasizes the importance of proactive policy-based governance in organizations (modeled as multiagent systems) and provides a novel architecture supporting policy monitoring, governance, and enactment. This paper provides an initial formalization and discusses the compliance and completeness of behaviors produced from specified policies. To demonstrate the practical utility of this approach, it is implemented using an existing policy engine and messaging middleware.
Rating issues in fault tolerant PMSM (2009)

The necessary reliability of a safety critical drive system is often partly achieved by using fault tolerant electrical machines. Although there are various degrees as to what types of faults and to the duration the machine has to tolerate, these generally include open and short circuit winding faults. There are numerous published literatures on the design of fault tolerant machines as well as on control algorithms used to maintain drive operation with an incurred fault. This paper is set to look at the effects of various fault tolerant control methods on the losses in three and five phase surface mount Permanent Magnet (PM) machines when in fault tolerant operation in order to be able to choose the correct rating for such conditions.
Genetic regulation of linolenic acid concentration in wild soybean Glycine soja accessions (1997)

Abstract Soybean [ Glycine max (L.) Merr.] oil from current commercial cultivars typically contains ca. 8% linolenic acid. Inheritance studies have shown that linolenic acid concentration in soybean seed is determined by at least two genes which govern activity of the predominant ω‐6 and ω‐3 desaturases. Selection of germplasm exhibiting homozygous recessive alleles that encode these desaturases has enabled development of soybeans having less than 3.0% linolenic acid. However, accessions of the wild ancestor of modern soybean cultivars, Glycine soja (Sieb. and Zucc.), have oils containing twice the highest linolenic acid concentration found in normal G. max cultivars. Although little is known about inheritance of linolenic acid in wild soybean, it would appear that additional or alternative forms of genes may govern its synthesis. To test this hypothesis, cultivated soybean germplasm was hybridized with wild soybean genotypes having significant differences in linolenic acid concentration. Seed of F 3 progeny from these G. max x G. soja populations exhibited distinct segregation patterns for relative estimates of ω‐6 and ω‐3 desaturase activity. Frequency class distribution analyses of the segregation patterns, and linear relations between median ω‐6 or ω‐3 desaturation estimates and corresponding linolenic acid concentration among allelic classes from these populations suggested the high‐linolenic acid trait in wild soybean genotypes was determined by a set of desaturase alleles that were different from corresponding alleles in G. max. Introgression of these alternative alleles in G. max germplasm opens a new avenue of research on the genitic regulation of linolenic acid, and may lead to the production of highly polyunsaturated soybean oils for various industrial applications.
Near-optimal and scalable intrasignal in-place optimization for non-overlapping and irregular access schemes (2013)

Storage-size management techniques aim to reduce the resources required to store elements and to concurrently provide efficient addressing during element accessing. Existing techniques are less appropriate for large iteration spaces with increased numbers of irregularly spread holes. They either have to approximate the accessed regions, leading to overestimation of the final resources, or they require prohibited exploration time to find the storage size. In this work, we present a near-optimal and scalable methodology for storage-size, intrasignal, in-place optimization, that is, to compute the minimum amount of resources required to store the elements of a group (array), for irregular complex access schemes in the target domain of non-overlapping store and load accesses.
Nocardia shimofusensis sp. nov., isolated from soil, and Nocardia higoensis sp. nov., isolated from a patient with lung nocardiosis in Japan (2004)

Three actinomycete strains isolated from soils and one strain isolated from a patient with lung nocardiosis in 1999 and 2001 in Japan have been provisionally assigned to the genus Nocardia on the basis of morphological criteria. These isolates were further investigated to determine their specific taxonomic status. Detailed chemotaxonomic characterization and 16S rRNA gene sequence analysis of these isolates confirmed that they belong to the genus Nocardia. The 16S rRNA gene sequences of the four strains were most similar to that of Nocardia farcinica. However, the sequence similarity values between these four strains and N. farcinica were <98.9 %. These four strains were susceptible to 5-fluorouracil, and they have the ability to decompose urea, which is a very characteristic trait. Furthermore, DNA-DNA relatedness data revealed that IFM 10311(T), IFM 10312 and IFM 10313 comprise a single novel species of Nocardia, that IFM 10084(T) represents another novel species of Nocardia and that these two novel species could be distinguished from N. farcinica. The names Nocardia shimofusensis sp. nov. and Nocardia higoensis sp. nov. are proposed, with IFM 10311(T) (=NBRC 100134(T)=JCM 12122(T)=DSM 44733(T)) and IFM 10084(T) (=NBRC 100133(T)=JCM 12121(T)=DSM 44732(T)) as the respective type strains.
Long-term stability of epicardial electrodes used in cardiac resynchronisation therapy (CRT) for heart failure (2007)

Objectives: Left ventricular stimulation for CRT can be achieved by transvenous coronary sinus or epicardial approach. CS-approach is combined with significant longer operation an fluoroscopy times and not always realizable. Frequency of epicardial approach amounts to 20% and remains stable over years. Long-term durability of epicardial electrodes is unknown. The aim of the study was to examine the long-term functional stability of epicardial electrodes.
Eco-Friendly, Set-on-Demand Digital Concrete (2021)

Digital fabrication with concrete is considered to potentially revolutionize the construction sector and is often presented as a means to reduce its environmental footprint. However, at least in the case of concrete, it encounters significant challenges in terms of material design, since high paste volumes and Portland cement contents are normally used due to process requirements. In this article, the application to layered extrusion of a recently developed low clinker cement containing 50% Portland cement and 50% supplementary cementitious materials, such as limestone, burnt oil shale, and fly ash, is presented. It is found that an accelerator paste composed by Calcium Aluminate Cement (CAC) and anhydrite provides the required hydration and structural build-up for 3D printing, while not compromising the early and long-term compressive strength. Such a low clinker mortar can be successfully retarded, processed, pumped, and extruded just after mixing it in line with the accelerator paste. This accelerated mortar formulation contains only 303 kg/m<sup>3</sup> of Portland cement, which is roughly half the amount used in current accelerated formulations used for digital fabrication with concrete.
Light sheet fluorescence microscopy using high-speed structured and pivoting illumination (2016)

We show that light sheet fluorescence microscopy with structured and pivoting illumination enables fast image acquisition and improved image quality. A one-dimensional spatial light phase modulator is used to control the illumination profile at high speed. To demonstrate the features of the system, we image fluorescent beads and biological samples, successfully obtaining optically sectioned images with higher contrast using structured illumination and with reduced shadowing effects using pivoting illumination.
Pair breaking caused by magnetic impurities in the high-temperature superconductor Bi2.1Sr1.9Ca(Cu1−xFex)2Oy (2013)

Conventional superconductivity is robust against the addition of impurities unless the impurities are magnetic in which case superconductivity is quickly suppressed. Here we present a study of the cuprate superconductor Bi${}_{2}$Sr${}_{2}$Ca${}_{1}$Cu${}_{2}$O${}_{8+\ensuremath{\delta}}$ that is intentionally doped with the magnetic impurity, Fe. Through the use of our tomographic density of states technique, we find that while the superconducting gap magnitude is essentially unaffected by the inclusion of iron, the onset of superconductivity, ${T}_{\mathrm{C}}$, and the pair-breaking rate are strongly dependent and correlated. These findings suggest that, in the cuprates, the pair-breaking rate is critical to the determination of ${T}_{\mathrm{C}}$ and that magnetic impurities do not disrupt the strength of pairing but rather the lifetime of the pairs.
Particle Image Velocimetry Applications Using Fluorescent Dye-doped Particles (2015)

Polystyrene latex sphere particles are widely used to seed flows for velocimetry techniques such as Particle Image Velocimetry (PIV) and Laser Doppler Velocimetry (LDV). These particles may be doped with fluorescent dyes such that signals spectrally shifted from the incident laser wavelength may be detected via Laser Induced Fluorescence (LIF). An attractive application of the LIF signal is achieving velocimetry in the presence of strong interference from laser scatter, opening up new research possibilities very near solid surfaces or at liquid/gas interfaces. Additionally, LIF signals can be used to tag different fluid streams to study mixing. While fluorescence-based PIV has been performed by many researchers for particles dispersed in water flows, the current work is among the first in applying the technique to micron-scale particles dispersed in a gas. A key requirement for such an application is addressing potential health hazards from fluorescent dyes; successful doping of Kiton Red 620 (KR620) has enabled the use of this relatively safe dye for fluorescence PIV for the first time. In this paper, basic applications proving the concept of PIV using the LIF signal from KR620-doped particles are exhibited for a free jet and a twophase flow apparatus. Results indicate that while the fluorescence PIV techniques are roughly 2 orders of magnitude weaker than Mie scattering, they provide a viable method for obtaining data in flow regions previously inaccessible via standard PIV. These techniques have the potential to also complement Mie scattering signals, for example in multi-stream and/or multi-phase experiments.
Identification of differentially expressed miRNAs and miRNA-targeted genes in bladder cancer (2018)

Identification of differential gene expression in specific tumor types could facilitate development of cancer diagnosis and aid in the early detection of BC.