gebhart/patrepeval huggingface dataset:
Bacterial biofilm shows persistent resistance to liquid wetting and gas penetration (2010)

Most of the world's bacteria exist in robust, sessile communities known as biofilms, ubiquitously adherent to environmental surfaces from ocean floors to human teeth and notoriously resistant to antimicrobial agents. We report the surprising observation that Bacillus subtilis biofilm colonies and pellicles are extremely nonwetting, greatly surpassing the repellency of Teflon toward water and lower surface tension liquids. The biofilm surface remains nonwetting against up to 80% ethanol as well as other organic solvents and commercial biocides across a large and clinically important concentration range. We show that this property limits the penetration of antimicrobial liquids into the biofilm, severely compromising their efficacy. To highlight the mechanisms of this phenomenon, we performed experiments with mutant biofilms lacking ECM components and with functionalized polymeric replicas of biofilm microstructure. We show that the nonwetting properties are a synergistic result of ECM composition, multiscale roughness, reentrant topography, and possibly yet other factors related to the dynamic nature of the biofilm surface. Finally, we report the impenetrability of the biofilm surface by gases, implying defense capability against vapor-phase antimicrobials as well. These remarkable properties of B. subtilis biofilm, which may have evolved as a protection mechanism against native environmental threats, provide a new direction in both antimicrobial research and bioinspired liquid-repellent surface paradigms.
Range of Motion Testing of a Novel 3D-Printed Synthetic Spine Model (2019)

This study identified relevant variables that affect synthetic spine model ROM and compressibility, confirmed that the models perform predictably with changes in these print variables, and identified a set of model parameters that result in a synthetic model with overall ROM that approximates that of a cadaveric model. Future studies can be undertaken to refine model performance and determine intermodel variability.
Una tipica manifestazione di Sindrome Cardio-Renale di Tipo 5: lo shock settico (2013)

La Sindrome Cardio-Renale (SCR) di Tipo 5 si configura come una sindrome clinica di recente classificazione e viene diagnosticata in un'ampia serie di patologie sistemiche, allorché si assiste a un contemporaneo interessamento secondario di rene e apparato cardiovascolare. I meccanismi fisiopatologici dipendono, sostanzialmente, dalla tempistica con la quale si manifesta una SCR di Tipo 5; ben diverso è il quadro di una forma acuta (sepsi, connettiviti, malattia di Wegener), che si manifesta rapidamente rispetto all'insorgenza della patologia primitiva, in contrasto con quello di una forma cronica (cirrosi epatica e sindrome epato-renale), che esordisce e si sviluppa subdolamente. La diagnosi si basa sul dosaggio dei livelli plasmatici di bio-marcatori di danno cardiaco e renale e sulle tecniche di diagnostica per immagini (ecocardiografia, ecografia addominale). La terapia deve mirare al trattamento della patologia di base e a quello delle complicanze cardio-renali. (Cardionephrology)
Quantum dot emission modulation using piezoelectric photonic crystal MEMS resonators (2017)

Quantum dots (QDs) integration into photonic devices requires varied approaches to control and modulate their emission. We demonstrate voltage-tunable PC structures with integrated QDs over suspended piezoelectric aluminum nitride thin film resonators that modulate PC enhancement at MHz frequencies. When the piezoelectric device is actuated at its resonant mechanical frequency, the extracted QD emission direction is likewise modulated via the optical resonant frequency of the PC. Modulation uses nanometer-scale mechanical displacements, offering the potential for greater switching speed and improved mechanical robustness that is not subject to the effects of stiction with a scalable fabrication approach.
The influence of HE history, HE status and neuropsychological test type on learning ability in patients with cirrhosis (2019)

HE status on the day of study and the type of neuropsychological test had an effect on learning ability in a well-characterized group of patients with cirrhosis.
Totalsynthese von Calicheamicin‐Dynemicin‐Hybridmolekülen (1992)

Synthetische Endiin‐Cytostatica/Antibiotica sind das Ziel präparativer Arbeiten wie der hier beschriebenen. Von den vier isomeren Calicheamicin‐Dynemicin‐Hybridverbindungen, die hierbei erhalten wurden, sind nur diejenigen cytostatisch wirksam, die an allen Stereozentren die gleiche Konfiguration wie Calicheamicin haben. Eines der wirksamen Isomere ist 1 . magnified image
Reninoma Presenting in Pregnancy (2014)

23-year-old Caucasian female was diagnosed with hypertension and controlled with an angiotensinconverting enzyme inhibitor and a beta-blocker. Two years later, she developed hypokalemia. She had normal urineandplasmacatecholaminesandmetanephrines,and aldosterone was appropriately suppressed in a saline suppression test. Computed tomography angiogram (CTA) andmagneticresonanceangiographydidnotdetectstructural renal or adrenal causes. She then became pregnant; theangiotensin-convertingenzymeinhibitorwaschanged to a calcium channel blocker and methyldopa, without however maintaining adequate control. At 26 weeks of pregnancy, she underwent cesarean section for hemolysis, elevated liver enzymes, and low platelet count (HELLP syndrome);thenewborninfantdiedaftera4-weekcomplicated course in intensive care. The patient was referred later to the National Institutes of Health for uncontrolled hypertension. Her upright plasma renin activity was 20 ng/mL/h (normal, 4.3), and her aldosterone level was 110 ng/dL (normal,21). CTA, magnetic resonance angiography, positron emission tomography, and renal venous sampling established the diagnosis of a 1-cm left kidney renin-secreting lesion (Figure 1, A–C and E). Her blood pressure normalized immediately after a left partial nephrectomy. Histopathology was consistent with a juxtaglomerular cell tu
Patterns of relapse and implications for post-nephrectomy surveillance for patients with high-risk non-clear cell renal cell carcinoma: Subgroup analysis of the phase 3 ECOG-ACRIN E2805 trial. (2018)

4564 Background: Non-clear cell renal cell carcinomas (non-ccRCC) comprise a diverse subgroup, with biology and clinical behavior that is distinct from clear cell RCC (ccRCC). However, the natural history of non-ccRCC remains poorly defined, and clinical practice relies on consensus guidelines largely intended for ccRCC. We evaluated the patterns of relapse and the implications for post-nephrectomy surveillance for patients with non-ccRCC enrolled on the first and largest randomized trial of adjuvant anti-angiogenic therapy for high-risk RCC. Methods: Retrospective subgroup analysis of patients with non-ccRCC enrolled on E2805. For recurrence rates (RR) by site, the cumulative incidence was estimated accounting for competing risks. Gray’s test was used to compare the incidence between groups. The 2017 NCCN recommendations were used to evaluate the adequacy of strict adherence to post-nephrectomy surveillance guidelines. Results: 403 non-ccRCC patients were enrolled (37% papillary, 28% chromophobe, 21% mixed, 14% unclassified). 144 recurrences were detected over a median follow-up of 6.2 years. 5-year RRs (95% CI) were 22% (11, 28) and 49% (41, 56) for Int-High and Very-High UISS risk groups, respectively. Abdominal recurrences were most frequently identified, including lymph node (39%), nephrectomy bed (17%), and liver (13%). While overall 5-year RRs were comparable between non-ccRCC and ccRCC patients (34.6% vs 39.5%), non-ccRCC patients were significantly more likely to develop abdominal site relapse (5-yr RR 26.4% vs 18.2%, p = 0.0008) and less likely to relapse in the chest (5-yr RR 13.7% vs 20.9%, p = 0.0005). Surveillance imaging for 5.3 years would be required to capture 95% of abdominal non-ccRCC recurrences. Conclusions: This is the largest, standardized evaluation of the natural history of non-ccRCC following curative-intent nephrectomy. Our findings demonstrate that non-ccRCC exhibits a distinct pattern of relapse when compared to conventional ccRCC, and emphasize the importance of continued long-term imaging for patients with high-risk resected non-ccRCC.
Patch2CAD: Patchwise Embedding Learning for In-the-Wild Shape Retrieval from a Single Image (2021)

3D perception of object shapes from RGB image input is fundamental towards semantic scene understanding, grounding image-based perception in our spatially 3-dimensional real-world environments. To achieve a mapping between image views of objects and 3D shapes, we leverage CAD model priors from existing large-scale databases, and propose a novel approach towards constructing a joint embedding space between 2D images and 3D CAD models in a patch-wise fashion -- establishing correspondences between patches of an image view of an object and patches of CAD geometry. This enables part similarity reasoning for retrieving similar CADs to a new image view without exact matches in the database. Our patch embedding provides more robust CAD retrieval for shape estimation in our end-to-end estimation of CAD model shape and pose for detected objects in a single input image. Experiments on in-the-wild, complex imagery from ScanNet show that our approach is more robust than state of the art in real-world scenarios without any exact CAD matches.
Supplementary Figure Legend from Identification and Characterization of MEL-3, a Novel AR Antagonist That Suppresses Prostate Cancer Cell Growth (2023)

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Cover Picture: Supramolecular Construction of Molecular Ladders in the Solid State (Angew. Chem. Int. Ed. 2/2003) (2003)

A supramolecular approach to covalent synthesis allows the photoconversion of polyenes into ladderanes, which are challenging synthetic targets discovered in the lipid membranes of the anammox bacteria that participate in the oceanic nitrogen cycle. In their Communication on page 232 ff. X. Gao, T. Friščić, and L. R. MacGillivray explain how solid‐state synthesis directed by molecular templates can provide gram quantities of the ladderanes in quantitative yield. Thus, ladderanes bridge a gap between conventional synthesis, supramolecular chemistry, and biology.
Beacon Beams for Deep Turbulence High Energy Laser Beam Directors (2012)

Abstract : The objective of this report is to outline a new type of beam director for deep turbulence propagation of high energy lasers (HELs). The proposed beam director is based on a new and innovative approach employing a Brillouin enhanced four-wave mixing mechanism for generating a tight (small spot size) beacon beam on a remote target. This mechanism results in amplification and complete conjugation (phase and amplitude) of the beacon beam without the need for wavefront sensors, deformable mirrors or predictive feedback algorithms. Complete phase conjugation is critical for beam control in the presence of strong turbulence. Conventional AO techniques do not have this capability. The beacon beam phase information from the beacon beam can be used in conjunction with an AO system to propagate HEL beams in deep turbulence.
Local Velocity Analysis by Parametric Wavenumber Estimation in Seismic - fk-MUSIC (2002)

P171 LOCAL VELOCITY ANALYSIS BY PARAMETRIC WAVENUMBER ESTIMATION IN SEISMIC (FK- MUSIC) KAMBIZ IRANPOUR 1 EVERHARD MUYZERT 2 and SERGIO GRION 3 Abstract 1 In seismic data analysis the generation of high-resolution frequency-wavenumber (fk) spectra using only a small number of sensors is highly desirable and will have wide ranging applications. Such applications include local velocity measurements and the detection of dispersive waves. When relatively few samples are available parametric methods give a superior wavenumber resolution compared to a standard fk-transform. We will show how parametric methods can be adjusted to wavenumber estimation and local velocity estimation in seismic. The
THE PIG AS A BIOMEDICAL MODEL: HOW THE NATIONAL SWINE RESOURCE AND RESEARCH CENTER CAN HELP YOU (2011)

Swine are an excellent large animal model for human health and disease because their size and physiology are similar to humans, and the progression of many diseases, such as cardiovascular disease, is similar to humans. Due to these similarities, technology, procedures, and novel treatments that have been developed for human diseases can be applied to swine, and vice versa. In addition there are some human diseases, such as cystic fibrosis, that don't recapitulate in the rodent models but are well modeled in swine. Swine have been accepted as the model of choice for several medical applications such as xenotransplantation and surgical training for medical students. Because of the usefulness of swine to better understand human health, the National Institutes of Health has established the National Swine Research and Resource Center to help meet the needs of the biomedical community. While wild type swine and spontaneous mutants have been shown to be valuable, genetically engineered swine provide a new level of utility. With the improvement of the techniques to add genes and make targeted genetic modifications not only have the number of types of genetically engineered pigs increased, but also the number of different diseases modeled have increased. The completion of the swine genome combined with development and improvements of techniques for gene modification will only enhance the continued use and development of swine as models of human health, syndromes and conditions. The resources at the National Swine Resource and Research Center are available to aid investigators with their swine needs for biomedical research. Here will be discussed the importance of swine as a biomedical model, current technologies to produce genetically engineered swine, current biomedical models, and how the completion of the swine genome will promote swine as a biomedical model.
Sticky Policies: An Approach for Managing Privacy across Multiple Parties (2011)

Machine-readable policies can stick to data to define allowed usage and obligations as it travels across multiple parties, enabling users to improve control over their personal information. The EnCoRe project has developed such a technical solution for privacy management that is suitable for use in a broad range of domains.
1703: Noninvasive Detection of TMPRSS2:Erg Fusion Transcripts in the Urine of Men with Prostate Cancer (2007)

You have accessJournal of UrologyModerated Poster 53, Wednesday, May 23, 2007, 8:00 - 10:00 am1 Apr 20071703: Noninvasive Detection of TMPRSS2:Erg Fusion Transcripts in the Urine of Men with Prostate Cancer David S. Morris, Scott A. Tomlins, Bharathi Laxman, Rohit Mehra, Rajal B. Shah, Mark A. Rubin, John T. Wei, and Arul M. Chinnaiyan David S. MorrisDavid S. Morris More articles by this author , Scott A. TomlinsScott A. Tomlins More articles by this author , Bharathi LaxmanBharathi Laxman More articles by this author , Rohit MehraRohit Mehra More articles by this author , Rajal B. ShahRajal B. Shah More articles by this author , Mark A. RubinMark A. Rubin More articles by this author , John T. WeiJohn T. Wei More articles by this author , and Arul M. ChinnaiyanArul M. Chinnaiyan More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)31891-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1703: Noninvasive Detection of TMPRSS2:Erg Fusion Transcripts in the Urine of Men with Prostate Cancer." The Journal of Urology, 177(4S), pp. 565–566 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 565-566 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information David S. Morris More articles by this author Scott A. Tomlins More articles by this author Bharathi Laxman More articles by this author Rohit Mehra More articles by this author Rajal B. Shah More articles by this author Mark A. Rubin More articles by this author John T. Wei More articles by this author Arul M. Chinnaiyan More articles by this author Expand All Advertisement PDF DownloadLoading ...
The pathogenic mechanism of diabetes varies with the degree of overexpression and oligomerization of human amylin in the pancreatic islet β cells (2014)

The aggregation of human amylin (hA) to form cytotoxic structures has been closely associated with the causation of type 2 diabetes. We sought to advance understanding of how altered expression and aggregation of hA might link β-cell degeneration with diabetes onset and progression, by comparing phenotypes between homozygous and hemizygous hA-transgenic mice. The homozygous mice displayed elevated islet hA that correlated positively with measures of oligomer formation (r=0.91; P<0.0001). They also developed hyperinsulinemia with transient insulin resistance during the prediabetes stage and then underwent rapid β-cell loss, culminating in severe juvenile-onset diabetes. The prediabetes stage was prolonged in the hemizygous mice, wherein β-cell dysfunction and extensive oligomer formation occurred in adulthood at a much later stage, when hA levels were lower (r=-0.60; P<0.0001). This is the first report to show that hA-evoked diabetes is associated with age, insulin resistance, progressive islet dysfunction, and β-cell apoptosis, which interact variably to cause the different diabetes syndromes. The various levels of hA elevation cause different extents of oligomer formation in the disease stages, thus eliciting early- or adult-onset diabetes syndromes, reminiscent of type 1 and 2 diabetes, respectively. Thus, the hA-evoked diabetes phenotypes differ substantively according to degree of amylin overproduction. These findings are relevant to the understanding of the pathogenesis and the development of experimental therapeutics for diabetes.
Evaluation on Mechanical Properties of Sn-Bi-Ag Solder and Reliability of the Solder Joint (2015)

This paper presents low-temperature Pb-free soldering technology using Sn-57Bi-1Ag (mass%). Here, the effects of high-temperature annealing on the mechanical properties of the solder such as tensile strength and elongation are investigated. The experimental results show that during annealing, the sizes of both of Sn and Bi phases coarsen, however the mechanical properties do not deteriorate. The deformation behavior of Sn-57Bi-1Ag is found to be dependent on sliding at grain boundaries between Sn and Bi phases, and this behavior remains consistent even after coarsening. The creep strength of solder joint at high temperature is also studied, and it is found that Sn-57Bi-1Ag exhibits superior creep strength at temperature below approximately 100°C compared to the Sn-37Pb (mass%) solder.The thermal cycling test of Sn-57Bi-1Ag solder joint is also conducted under the condition between 0°C and 90°C. The result shows that the length of crack is shorter than Sn-37Pb in the same conditions, which means Sn-57Bi-1Ag is an effective material for low temperature soldering.
An electrical-matching, boil-off flow calorimeter (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn electrical-matching, boil-off flow calorimeterPhilip T. Eubank, James C. Holste, Luis E. Cediel, David H. Moor, and Kenneth R. HallCite this: Ind. Eng. Chem. Fundamen. 1984, 23, 1, 105–109Publication Date (Print):February 1, 1984Publication History Published online1 May 2002Published inissue 1 February 1984https://pubs.acs.org/doi/10.1021/i100013a019https://doi.org/10.1021/i100013a019research-articleACS PublicationsRequest reuse permissionsArticle Views36Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Transmission properties of tapered air-core photonic bandgap fibers (2006)

Fiber tapers have found a wide range of important applications in communication and sensing, including narrow-band filters, mode-matching between waveguides, evanescent mode-coupling and fused couplers. Applying these taper-based technologies to air-core photonic bandgap fibers (PBFs) is very appealing because it would enable creating these same components directly in air-core fibers. Although there have been several studies of tapers in solid-core microstructured fibers, the transmission properties of tapered air-core photonic-bandgap fibers have not yet been studied. In this work, we report on the fabrication and testing of tapered air-core photonic-bandgap fibers. Our motivation in this work was to study the basic transmission properties of PBF bitapers in the bandgap region, and in particular, to see how the overall transmission was impacted by the taper, e.g., whether the taper induced resonant coupling to one or more cladding modes. Our experimental results indicate that air-core PBFs are highly sensitive to tapering, and unlike conventional single-mode telecommunication fibers, even a small tapering ratio results in significant modal interference in the transmission spectrum. Furthermore, we found out that the mechanical silica support surrounding the holey region of the PBF contributes as a lossy Fabry-Perot resonator to the observed transmission properties.
Supplementary Material for: Prey-Capture Strategies of Fish-Hunting Cone Snails: Behavior, Neurobiology and Evolution (2016)

The venomous fish-hunting cone snails <i>(Conus)</i> comprise eight distinct lineages evolved from ancestors that preyed on worms. In this article, we attempt to reconstruct events resulting in this shift in food resource by closely examining patterns of behavior, biochemical agents (toxins) that facilitate prey capture and the combinations of toxins present in extant species. The first sections introduce three different hunting behaviors associated with piscivory: ‘taser-and-tether', ‘net-engulfment' and ‘strike-and-stalk'. The first two fish-hunting behaviors are clearly associated with distinct groups of venom components, called cabals, which act in concert to modify the behavior of prey in a specific manner. Derived fish-hunting behavior clearly also correlates with physical features of the radular tooth, the device that injects these biochemical components. Mapping behavior, biochemical components and radular tooth features onto phylogenetic trees shows that fish-hunting behavior emerged at least twice during evolution. The system presented here may be one of the best examples where diversity in structure, physiology and molecular features were initially driven by particular pathways selected through behavior.<br>
Nocturnal Glucose Metabolism in Type 1 Diabetes: A Study Comparing Single Versus Dual Tracer Approaches (2015)

The data demonstrate a consistent overnight rise in glucose concentrations through increased EGP, mediated likely by rising cortisol concentrations. The observations with the dual tracer approach imply significant tracer recycling leading to underestimation of EGP measured by longer-duration tracer infusion.