gebhart/patrepeval huggingface dataset:
Investigations of Iridium-Mediated Reversible C−H Bond Cleavage: Characterization of a 16-Electron Iridium(III) Methyl Hydride Complex (2009)

New iridium complexes of a tridentate pincer ligand, 2,6-bis(di-tert-butylphosphinito)pyridine (PONOP), have been prepared and used in the study of hydrocarbon C-H bond activation. Intermolecular oxidative addition of a benzene C-H bond was directly observed with [(PONOP)Ir(I)(cyclooctene)][PF(6)] at ambient temperature, resulting in a cationic five-coordinate iridium(III) phenyl hydride product. Protonation of the (PONOP)Ir(I) methyl complex yielded the corresponding iridium(III) methyl hydride cation, a rare five-coordinate, 16-valence electron transition metal alkyl hydride species which was characterized by X-ray diffraction. Kinetic studies of C-H bond coupling and reductive elimination reactions from the five-coordinate complexes have been carried out. Exchange NMR spectroscopy measurements established a barrier of 17.8(4) kcal/mol (22 degrees C) for H-C(aryl) bond coupling in the iridium(III) phenyl hydride cation and of 9.3(4) kcal/mol (-105 degrees C) for the analogous H-C(alkyl) coupling in the iridium(III) methyl hydride cation. The origin of the higher barrier of H-C(aryl) relative to H-C(alkyl) bond coupling is proposed to be influenced by a hindered rotation about the Ir-C(aryl) bond, a result of the sterically demanding PONOP ligand.
Supplementary Table 1 from Mitochondrial/Cell-Surface Protein p32/gC1qR as a Molecular Target in Tumor Cells and Tumor Stroma (2023)

Supplementary Table 1 from Mitochondrial/Cell-Surface Protein p32/gC1qR as a Molecular Target in Tumor Cells and Tumor Stroma
VO2-based Active Terahertz Chiral Metamaterials (2019)

In this paper, we demonstrate a vanadium dioxide (VO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) integrated chiral metamaterial exhibiting tunable chiroptical responses at terahertz frequencies. Simulated results show that a circular dichroism of ~40° and a maximum polarization rotation of ~200°/λ can be achieved around 0.7 THz with VO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> in its metallic phase. More importantly, the chiroptical response from the hybrid metamaterial varies dramatically with the phase transition determined by the THz conductivity of VO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> . Our results reveal that the unification of structured metals and phase-change materials provides the foundation to establish a new paradigm for THz chiroptical metadevices.
Smoking, Socioeconomic Factors, and Age-Related Cataract (2010)

Smoking and indicators of low socioeconomic status were associated with cataract in Malay persons, with 1 in 6 nuclear cataract cases in men attributable to smoking. Smoking-cataract associations were stronger in Malay than in white persons.
Soybean Oil-Based Biopolymers Induced by Nonthermal Plasma to Enhance the Dyeing of Para-Aramids with a Cationic Dye (2022)

To overcome the recalcitrance of para-aramid textiles against dyeing, this study demonstrated that increasing the functionalities of soybean oil applied to the surface of para-aramids followed by a nonthermal plasma (NTP) treatment improved the dyeing color strength compared with the use of soybean oil alone, and that dyeing occurred through covalent bonding. Particularly, compared with the pretreatment using soybean oil that obtained the highest color strength of 3.89 (as K/S value determined from spectral analysis of the sample reflectance in the visible range), the present pretreatments with either acrylated epoxidized soybean oil (AESO) or a mixture of acrylic acid and soybean oil (AA/Soy) achieved K/S values higher than nine (>9.00). The NTP treatment, after the AESO or AA/Soy pretreatment, was essential in inducing the formation of a polymerized network on the surface of para-aramids that bonded the dye molecules and generating covalent bonds that anchored the polymerized network to the para-aramids, which is difficult to achieve given the high crystallinity and chemical inertness of para-aramids. As an important economic consideration, the sequential experimentation method demonstrated that a simple mixture of AA/Soy could replace the expensive AESO reagent and render a comparable performance in dyeing para-aramids. Among the auxiliary additives tested with the AESO and AA/Soy pretreatments followed by NPT treatment in this study, Polysorbate 80 as a surfactant negatively affected the dyeing, benzyl alcohol as a swelling agent had minimal effect, and NaCl as an electrolyte showed a positive effect. The dyeing method developed in this study did not compromise the strength of para-aramids.
Fungal Burn Wound Infection (1991)

To evaluate our experience with fungal burn wound infection, we performed a 10-year review for comparison with our experience with bacterial burn wound infection. During the study period, a marked decline occurred in bacterial wound infection but not in fungal wound infection. Patients with either bacterial or fungal burn wound infection had massive injury, with burn size averaging greater than 50% of the total body surface area. Factors that appear to have markedly reduced bacterial burn wound infection, including patient isolation, topical chemotherapeutic agents, and burn wound excision, do not appear to have had a similar effect on fungal wound infection. The mechanism of spread and colonization of fungi, and the lack of effective topical chemotherapeutic antifungal agents, may explain in part our findings.
Dual Channel EM/Power Attack Using Mutual Information and its Real-time Implementation (2023)

Cryptosystem implementations often leak information about a secret key due to correlation with side channels such as power, timing, EM, etc. Based on this principle, statistical and machine-learning-based side-channel attacks have been investigated, most often using a single channel or modality such as power; however, EM is growing in popularity. Since power and EM channels can leak distinct information, the combination of EM and power channels could increase side-channel attack efficiency. In this paper, we combine EM and power channels in a linear fashion by using mutual information to determine the optimal coefficients for each feature. Mutual information is also systematically applied for lightweight dimensionality reduction. Further, the proposed methodology is implemented onto a platform to simultaneously measure power and EM traces and process them in real time to extract AES subkeys. With the proposed dual channel approach, the success rate increases by at least 30% compared to single power/EM channels in the offline mode and over 50% in the real-time mode.
Space Division Multiplexed Transmission of 109-Tb/s Data Signals Using Homogeneous Seven-Core Fiber (2012)

We achieved record 109-Tb/s transmission over 16.8 km, using space division multiplexing (SDM) together with conventional multiplexing technology. 7-core SDM, 97 WDM (100-GHz spacing), 2 × 86 Gb/s PDM-QPSK signals were used. The spectral efficiency was 11.2 b/s/Hz. SDM transmission was realized using a multi-core fiber with ultra-low-crosstalk (less than -90.0 dB/km at 1550 nm) and high performance SDM MUX/DEMUX. The overall SDM crosstalk of -53 dB caused almost no penalty for the PDM-QPSK transmission.
Multiresolution Finite Element Mesh Generation (2004)

Effective and robust automatic generation methods of finite element mesh of product model are required for CAE. Although many researches for them have been done, robust mesh generation for complex solid shapes with small features and flexible mesh property control are still difficult in current finite element meshers. In this paper, we propose a new method for automatic finite element mesh generation of a product model based on multiresolution representation of high-density mesh which are stably generated by existing finite element meshers. In our approach, geometrical and topological mesh properties required for FEA can be controlled using user-specified parameters, and mesh elements corresponding to the solid model elements used for setting the analysis conditions are preserved on the simplified meshes. Using our method, robust finite element mesh generation where the mesh property is controllable could be realized.
Bidirectional tuning of microring-based silicon photonic transceivers for optimal energy efficiency (2019)

Microring-based silicon photonic transceivers are promising to resolve the communication bottleneck of future high-performance computing systems. To rectify process variations in microring resonance wavelengths, thermal tuning is usually preferred over electrical tuning due to its preservation of extinction ratios and quality factors. However, the low energy efficiency of resistive thermal tuners results in nontrivial tuning cost and overall energy consumption of the transceiver. In this study, we propose a hybrid tuning strategy which involves both thermal and electrical tuning. Our strategy determines the tuning direction of each resonance wavelength with the goal of optimizing the transceiver energy efficiency without compromising signal integrity. Formulated as an integer programming problem and solved by a genetic algorithm, our tuning strategy yields 32%~53% savings of overall energy per bit for measured data of 5-channel transceivers at 5~10 Gb/s per channel, and up to 24% saving for synthetic data of 30-channel transceivers, generated based on the process variation models built upon measured data. We further investigated a polynomial-time approximation method which achieves over 100x speedup in tuning scheme computation, while still maintaining considerable energy-per-bit savings.
SPC03-3: A MIMO-MLSE Receiver for Electronic Dispersion Compensation of Multimode Optical Fibers (2006)

In this paper we propose a multiple-input, multiple-output (MIMO) maximum-likelihood sequence estimation (MLSE) receiver for electronic dispersion compensation (EDC) of multimode optical fibers at 10 Gb/s data rate. As the primary example of the effectiveness of the techniques introduced here we present a receiver for the emergent 10 GBASE-LRM standard for 10 Gb/s Ethernet over multimode optical fibers [1]. We show that an MLSE receiver provides an advantage of at least 2 dB over other receivers, such as the decision-feedback equalizer (DFE), on 99% of the local area network (LAN) multimode fiber population, as modeled by a database proposed by the IEEE 802.3aq Task Force [2]. The paper deals with both theoretical and practical aspects of the architecture. To enable the complete integration of this receiver as a single chip in current 90 nm CMOS technology, we propose the parallel-processing digital implementation of a feedforward equalizer (FFE) and a Viterbi decoder together with an interleaved front-end analog to digital converter (ADC). The MIMO structure jointly compensates for fundamental channel impairments such as multimode dispersion, and implementation-related effects such as the limitations of the analog front end (AFE), particularly the one known as fixed-pattern noise (FPN) [3]. As a result of the high speed operation, FPN has a major impact on performance. We show that, without compensation, FPN could result in a degradation of 7.86 dB. With the compensation proposed here, the latter is reduced to 0.23 dB.
Abstract IA46: Towards implementation of T-cell therapy in pancreatic cancer (2016)

Abstract In contrast to the general belief that pancreatic ductal adenocarcinoma is a poorly immunogenic tumor, we found cumulative evidence for an adaptive immune response in this aggressive cancer type. Immunohistochemistry reveals prominent T-cell infiltrates in the majority (~ 70%) of tumor biopsies, and these tumor-infiltrating lymphocytes (TILs) can be isolated and expanded ex vivo with similar efficiency as those isolated from melanoma. Furthermore, comparison of the T-cell receptor repertoire between TIL and PBMC isolates from patients points at the selective expansion of T-cell subsets in the tumors. Finally, in ~ 50% of tumor specimen, T-cell infiltration is accompanied by the presence of tertiary lymphoid structures that comprise areas rich in CD3+ T-cells and CD208+ dendritic cells as well as areas rich in B-cells and follicular dendritic cells. Based on these findings, our current efforts aim at: - Evaluating neoadjuvant treatment with agonist immunostimulatory antibodies as a means to mobilize this pre-existing immune response in patients with primary resectable disease* - Analysis of the anti-tumor reactivity and antigen-specificity of TCR-species that are prominently enriched in the tumor as compared to PBMC. - Exploration of TIL therapy for treatment of recurrent disease. * Clinical trial in context of FP7 EU IACT program; Immunostimulatory Antibodies for Cancer Treatment Citation Format: Rienk Offringa, Isabel Poschke, Michael Volkmar, Oliver Strobel, Frank Bergmann, Niels Halama, Dirk Jäger, Ugur Sahin, Markus Büchler. Towards implementation of T-cell therapy in pancreatic cancer. [abstract]. In: Proceedings of the CRI-CIMT-EATI-AACR Inaugural International Cancer Immunotherapy Conference: Translating Science into Survival; September 16-19, 2015; New York, NY. Philadelphia (PA): AACR; Cancer Immunol Res 2016;4(1 Suppl):Abstract nr IA46.
Use of Sequenom Sample ID Plus® SNP Genotyping in Identification of FFPE Tumor Samples (2014)

Short tandem repeat (STR) analysis, such as the AmpFlSTR® Identifiler® Plus kit, is a standard, PCR-based human genotyping method used in the field of forensics. Misidentification of cell line and tissue DNA can be costly if not detected early; therefore it is necessary to have quality control measures such as STR profiling in place. A major issue in large-scale research studies involving archival formalin-fixed paraffin embedded (FFPE) tissues is that varying levels of DNA degradation can result in failure to correctly identify samples using STR genotyping. PCR amplification of STRs of several hundred base pairs is not always possible when DNA is degraded. The Sample ID Plus® panel from Sequenom allows for human DNA identification and authentication using SNP genotyping. In comparison to lengthy STR amplicons, this multiplexing PCR assay requires amplification of only 76-139 base pairs, and utilizes 47 SNPs to discriminate between individual samples. In this study, we evaluated both STR and SNP genotyping methods of sample identification, with a focus on paired FFPE tumor/normal DNA samples intended for next-generation sequencing (NGS). The ability to successfully validate the identity of FFPE samples can enable cost savings by reducing rework.
Experimental Evaluation of the Medtronic Maxima Forte Hollow Fiber Membrane Oxygenator (1998)

A new hollow fiber membrane oxygenator, the Medtronic Maxima Forté, was tested for gas transfer, blood path resistance and blood handling characteristics in a standardized setting with surviving animals. Three calves (mean body weight: 71 +/- 9.6 kg) were placed on cardiopulmonary bypass at a mean flow rate of 50 ml/kg/min for six hours. The circuit included the Maxima Forté oxygenator. The animals were weaned from cardiopulmonary bypass and then from the ventilator. After seven days, the animals were sacrificed electively. Physiologic blood gas values could be maintained throughout perfusion in all animals. Mean pressure drop through the oxygenator varied between 49 mmHg and 66 mmHg. The respective baseline values for red blood cell count, white blood cell count and platelets were 8.90 +/- 1.26 10(6)/mm3, 7.46 +/- 3.17 10(3)/mm3. and 680 +/- 216 10(3)/mm3. Red blood cell and platelet counts dropped slightly to 7.26 +/- 1.61 10(6)/mm3 and 400 +/- 126 10(3)/mm3 at the end of the bypass, whereas the white blood cell count increased up to 9.13 +/- 5.25 10(3)/mm3. All three cell lines returned to near their baseline values after seven days. Blood trauma evaluated as a function of plasma hemoglobin (plasma Hb) and lactate dehydrogenase (LDH) showed stable values during all the perfusion time. Both peaked at 24 hours before returning to their baseline values at seven days. LDH showed a statistically significant variation: 3255 +/- 693 IU at 24 hours versus 2029 +/- 287 IU at baseline (p = 0.04). The variation of plasma Hb was not statistically significant (93.5 +/- 7.7 mumol/l at 24 hours versus 77.3 +/- 52.3 mumol/l at baseline) indicating a weak effect of the perfusion on blood trauma. The Medtronic Maxima Forté hollow fiber membrane oxygenator offered good gas exchange capabilities, a low pressure drop, and low blood trauma over a prolonged perfusion time of six hours in this evaluation.
The impact of biosynthesized ZnO nanoparticles from Olea europaea (Common Olive) on Pseudomonas aeruginosa growth and biofilm formation (2023)

There is a limitation in the range of effectual antibiotics due to the Pseudomonas aeruginosa (PA) infection due to its innate antimicrobial resistance. Researchers have therefore been concentrating their efforts to discover advanced and cost effective antibacterial agents among the ever-increasing PA bacterial resistance strains. It has been discovered that various nanoparticles can be employed as antimicrobial agents. Here, we evaluated the antibacterial properties of the Zinc Oxide nanoparticles (ZnO NPs), which was biosynthesized, being examined on six hospital strains of PA alongside a reference strain (ATCC 27853). A chemical approach was applied to biosynthesize the ZnO NPs from Olea europaea was performed, and confirmed by using X-ray diffraction and Scanning Electron Microscopes. The nanoparticles then applied their antibacterial properties to examine them against six clinically isolated PA strains alongside the reference strain. This process tested for the results of the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC). The Growth, biofilm formation and eradication were analyzed. The influence of the differentiating degrees ZnO NPs in regard to Quorom sensing gene expression were further examined. The ZnO NPs exhibited a crystalline size and diameter (Dc) of 40-60 nm and both the MIC and MBC tests revealed positive outcomes of concentrations of 3 and 6 mg/ml for each PA strain, respectively. At sub inhibitory concentration, The ZnO NPs were found to significantly inhibit the growth and biofilm formation of all PA strains and decreases in the biomass and metabolic behavior of PA established biofilms; these decreases varied depending on the dosage. At ZnO NPs concentrations of 900 µg/ml, the expression of majority of quorum sensing genes of all strains were significantly reduced, at ZnO NPs concentrations of 300 µg/ml, few genes were significantly impacted. In conclusion, the treatment of PA and could be other antibiotic resistant bacteria can therefore be approached by using ZnO NPs as it has been uncovered that they withhold advanced antibacterial properties.
A method for safely resecting anterior butterfly gliomas: the surgical anatomy of the default mode network and the relevance of its preservation (2016)

OBJECTIVE Gliomas invading the anterior corpus callosum are commonly deemed unresectable due to an unacceptable risk/benefit ratio, including the risk of abulia. In this study, the authors investigated the anatomy of the cingulum and its connectivity within the default mode network (DMN). A technique is described involving awake subcortical mapping with higher attention tasks to preserve the cingulum and reduce the incidence of postoperative abulia for patients with so-called butterfly gliomas. METHODS The authors reviewed clinical data on all patients undergoing glioma surgery performed by the senior author during a 4-year period at the University of Oklahoma Health Sciences Center. Forty patients were identified who underwent surgery for butterfly gliomas. Each patient was designated as having undergone surgery either with or without the use of awake subcortical mapping and preservation of the cingulum. Data recorded on these patients included the incidence of abulia/akinetic mutism. In the context of the study findings, the authors conducted a detailed anatomical study of the cingulum and its role within the DMN using postmortem fiber tract dissections of 10 cerebral hemispheres and in vivo diffusion tractography of 10 healthy subjects. RESULTS Forty patients with butterfly gliomas were treated, 25 (62%) with standard surgical methods and 15 (38%) with awake subcortical mapping and preservation of the cingulum. One patient (1/15, 7%) experienced postoperative abulia following surgery with the cingulum-sparing technique. Greater than 90% resection was achieved in 13/15 (87%) of these patients. CONCLUSIONS This study presents evidence that anterior butterfly gliomas can be safely removed using a novel, attention-task based, awake brain surgery technique that focuses on preserving the anatomical connectivity of the cingulum and relevant aspects of the cingulate gyrus.
Recent preclinical and clinical advances in oligonucleotide conjugates (2018)

The success of future conjugate strategies will likely rely on the effective combination of characteristics from earlier technologies. High-affinity ligand-receptor interactions can be critical to achieving meaningful accumulation in target tissues, but pharmacokinetic modulators which increase the circulating half-life may also be necessary. Synthesis of these approaches has the potential to bring the next breakthrough in oligonucleotide therapeutics.
Harmonic power detection in wideband cognitive radios (2009)

An analysis for simultaneous sensing of multiple primary user activity in cognitive radios has been presented here from a signal-processing perspective. First, the drawbacks of using simple harmonic power detection in wideband cognitive radios is demonstrated. Then, the impact of preprocessing the received signal to improve detection performance is highlighted along with its tradeoff involving complexity and corresponding delays in cognitive radio networks. It has been shown that a polyphase DFT filter bank with an optimal window as prototype filter can lead to reliable as well as efficient sensing and detection architecture in cognitive radios with minimal overhead. A detailed account of challenges, performance limits and computational complexity comparisons for various spectrum-sensing solutions is also provided. The study is supported through simulations with parameters corresponding to the IEEE 802.22 standard.
ChemInform Abstract: Preparation of 5‐Unsubstituted 4‐Formylpyrrole‐2‐carboxylates and Conversion to Cycloalkano‐oligopyrroles. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Investigation of 20% Scandium-doped Aluminum Nitride films for MEMS laterally vibrating resonators (2017)

RF filtering technologies based on piezoelectric MEMS resonators have been successfully developed and commercialized in the past decade thanks to their size and outstanding performance. The challenge to enhance filter's performance in terms of lower insertion losses and wider bandwidth still makes for an active research topic, especially spurring the interest for new classes of materials such as doped-AlN [1] and thin films of lithium niobate [2]. In this work, we investigate the use of 20% Scandium-doped Aluminum Nitride (ScAlN) thin films for the making of laterally vibrating MEMS resonators (LVRs). The main goals of our work are to demonstrate: 1) a higher k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> (~ 2x) compared to non-doped AlN, 2) ease of fabrication process compared to lithium niobate thin films [3], 3) fabrication of multi-frequency devices (250 MHz-1 GHz) on the same wafer.