gebhart/patrepeval huggingface dataset:
Preparation of ruthenium(0) and osmium(0) cyclooctatetraene complexes (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of ruthenium(0) and osmium(0) cyclooctatetraene complexesRichard R. Schrock and J. LewisCite this: J. Am. Chem. Soc. 1973, 95, 12, 4102–4103Publication Date (Print):June 1, 1973Publication History Published online1 May 2002Published inissue 1 June 1973https://pubs.acs.org/doi/10.1021/ja00793a075https://doi.org/10.1021/ja00793a075research-articleACS PublicationsRequest reuse permissionsArticle Views319Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effects of NKH477, a forskolin derivative, and dibutyryl‐cyclic AMP on adrenal catecholamine release in response to splanchnic nerve stimulation, acetylcholine, DMPP and muscarine in anesthetized dogs (1997)

The effects of NKH477, a water-soluble forskolin derivative, and dibutyryl-cyclic adenosine monophosphate (dbcAMP) on the release of adrenal catecholamines (CAs) in response to splanchnic nerve stimulation (SNS), acetylcholine (ACh), the nicotinic receptor stimulant 1,1-dimethyl-4-phenyl-piperazinium iodide (DMPP) and muscarine were examined in anesthetized dogs. NKH477, dbcAMP and the cholinergic agonists were infused and injected, respectively, into the adrenal gland intra-arterially. SNS (3 Hz) or injections of ACh (3 micrograms), DMPP (2 micrograms) and muscarine (2 micrograms) produced increases in CA output determined from adrenal venous blood. Both NKH477 infusion (0.3, 1 and 3 micrograms/min) and dbcAMP infusion (0.1, 0.3 and 1 mg/min) caused dose-dependent enhancement of the SNS-, ACh- and DMPP-induced increases in CA output, whereas they failed to affect the muscarine-induced increases in CA output. Neither NKH477 nor dbcAMP affected basal CA output. Cyclic AMP (cAMP) overflow determined from adrenal venous blood increased during NKH477 infusion. These results indicate that NKH477 and dbcAMP have facilitatory effects on adrenal CA release mediated by nicotinic receptors, but not by muscarinic receptors in the dog, and suggest the selective action of cAMP on nicotinic mechanism.
Introducing Electromagnetic Battery Sensors, with Unprecedented Performance (2020)

The chemistry of batteries have been improving constantly for the past century; however, the battery monitoring and thus management has not seen any real improvements since decades ago. Internal shorts cost manufacturing companies millions of dollars each year. This is because it takes days and weeks to screen for cells with potential internal shorts. If undetected, the faulty cells in the field can cause millions of dollars in damages. Therefore, significantly increasing the speed of detection may double the profit of the manufacturing company. Internal shorts is also one of the major challenges of fast charging batteries. Fast charging can lead to hard- micro shorts that can result in battery failure and thermal runaway. We have developed a completely new class of battery monitoring and screening sensors, PES™, first demonstrated by our team at Caltech in 2014. PES™ is an electromagnetic-based battery sensing platform, based on an extension of electrochemical impedance spectroscopy (EIS) to EM induction from an electrochemical system. Conventional battery testing is primarily based on voltage, impedance, and/or temperature monitoring, which generally register issues only after significant internal changes to the condition of the battery have occurred. PES™ detects minor changes in the electric field itself, and can identify small internal shorts and structural variations in the battery well before they register in voltage/temperature-based reading fluctuations. We have successfully demonstrated that it can detect gradually developing internal shorts, as large as 3300 ohms, which are extremely hard to detect by conventional voltage sensors. To significantly reduce the risk of failure and fire, the sensor should be an important part of any large Li-ion battery or any future Li-metal batteries. This class of sensors based on electromagnetism as opposed to the conventional voltage, current or temperature monitoring opens the door to many new applications, resulting in much higher utilization of batteries. Figure 1
Extracellular proteins of Cryptococcus neoformans and host antibody response (1997)

Proteins secreted by the fungal pathogen Cryptococcus neoformans may be involved in invasion and could be useful in vaccine design. Despite the medical importance of this fungus, little is known about its extracellular proteins or the immune response to these antigens. To study C. neoformans extracellular proteins, 12 strains were metabolically radiolabeled and protein supernatants were analyzed. Both strain- and growth condition-dependent differences were observed. Enzymatic assays of filtered culture supernatants revealed butyrate esterase and caprylate esterase lipase activity for 11 of 12 strains, as well as acid phosphatase, naphthol-AS-BI-phosphohydrolase, and beta-glucosidase activities in some strains. Serum from infected rodents immunoprecipitated several secreted proteins, consistent with in vivo expression and development of an antibody response. For strain 24067, two immunodominant species, of approximately 75 and 30 kDa, were recognized. The relative intensity of the autoradiographic bands depended on the route of infection for both rats and mice. In summary, our results indicate that (i) there are multiple proteins in C. neoformans culture supernatants, (ii) there are strain differences in supernatant protein profiles, (iii) there are differences in supernatant protein profile depending on the growth conditions, (iv) there are several new extracellular and/or cell-associated enzymatic activities, and (v) antibodies to several supernatant proteins are made in the course of infection.
Bioassay of Several Baculoviruses for Virus-Induced Mortality in Manduca sexta Larvae and Induction of Infection-Specific Protein (1994)

Neonate larvae of Monduca sexta were tested for susceptibility to five nuclear polyhedrosis viruses and three granulosis viruses using a droplet feeding assay. Autographa californica nuclear polyhedrosis virus (AcMNPV) and Erinnyis ello granulosis virus (EeGV) were found to infect and kill M. sexta larvae, with observed median survival times (ST50) of 94.6 ± 1.7 (SE) and 184.7 ± 24.3 (SE) hr, respectively. M. sexta larvae were also infected with EeGV late in the third instar, bled 8 and 11 days later, and their hemolymph was examined by SDS-PAGE for viral infection-specific proteins. The EeGV-infected larvae showed the presence of an infection-specific protein of molecular weight ca. 33kDa.
Effect of Mineral Oil on Porcine Urothelium (1997)

Mineral oil has been used to facilitate ureteral stone extraction and to treat selected patients with infected residual urine. The purpose of this study was to evaluate the effect of mineral oil on the urothelium. Twelve adult female farm pigs underwent bilateral ureteral catheter placement under general endotracheal anesthesia. Retrograde pyelograms were performed and the ureteral diameters measured. Using a randomization protocol, six animals underwent injection of 10 mL of normal saline into one ureteral catheter and 50 mL of normal saline instillation into the bladder. In the remaining six animals, 10 mL of mineral oil was injected into one ureteral catheter and 50 mL of mineral oil into the bladder. The instillation was maintained for 30 minutes, and then the catheters were removed. One week later, under general endotracheal anesthesia, cystoscopy and retrograde pyelography were performed to measure the diameter of the ureters, and the animals were euthanized. The bladder, ureters, and kidneys were harvested for macroscopic and histopathologic evaluation. There was no significant difference in the diameter of the ureters injected with normal saline, the uninjected ureters, or the mineral oil-injected ureters. The bladders, ureters, and kidneys were grossly normal in all animals. No significant histopathologic changes were noted in the ureteral or bladder urothelium or the renal parenchyma in the animals injected with mineral oil. In conclusion, the instillation of mineral oil within the urinary tract does not have any significant long-term functional or histopathologic effect on the urothelium.
Storage system control for fault protections of single phase loads in inverter-dominated grids (2017)

Nowadays micro-grids are taking a important role in power systems design, control and management. One of the key features of actual micro-grids is the predominant presence of power electronic converters, which limit the inertia of the system and the ability to provide high short circuit currents. In fact, power electronic converters limit the fault current to approximately 1.5 times their rated current. This could lead to a failure of traditional protections, based on high current detection. Different solutions to this problem have been proposed in literature. Among others, the exploitation of a storage system to increase the short circuit current and, thus, reach the pick-up value of traditional relays has been investigated. This paper deals with the results of tests on such an arrangement, carried out on a real micro-grid test facility at Politecnico di Milano premises.
Control of High-Order Harmonic Generation through Shaped Pulse Optimization (2000)

We demonstrate that using phase-only control of ultrafast pulses, we can selectively enhance the brightness of high-harmonic generation by over an order of magnitude, and generate near transform-limited soft x-ray pulses.
Role for expression of CD200 in multiparameter flow cytometric differential diagnosis of mature B-cell neoplasms (2017)

This issue of the journal includes an important study by Sandes et al. (1), which explores whether inclusion of analysis of CD200 expression can contribute to improved classification of mature B cell neoplasms (MBN). Currently, the most frequent subgroupings used for classification purposes are (2,3): CD5+CD10− [(chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL)]; CD5−CD10+ [Follicular lymphoma (FL), diffuse large B cell lymphoma (DLBCL), and Burkitt’s lymphoma]; and CD5−CD10− [marginal zone lymphoma (MZL), lymphoplasmacytic lymphoma, and lymphomas with hairy/villous cells including splenic marginal zone lymphoma (SMZL), and hairy cell leukemia (HCL)].
Can Deep Learning Using Weight Bearing Knee Anterio-Posterior Radiograph Alone Replace a Whole-Leg Radiograph in the Interpretation of Weight Bearing Line Ratio? (2021)

Weight bearing whole-leg radiograph (WLR) is essential to assess lower limb alignment such as weight bearing line (WBL) ratio. The purpose of this study was to develop a deep learning (DL) model that predicts the WBL ratio using knee standing AP alone. Total of 3997 knee AP & WLRs were used. WBL ratio was used for labeling and analysis of prediction accuracy. The WBL ratio was divided into seven categories (0, 0.1, 0.2, 0.3, 0.4, 0.5, and 0.6). After training, performance of the DL model was evaluated. Final performance was evaluated using 386 subjects as a test set. Cumulative score (CS) within error range 0.1 was set with showing maximum CS in the validation set (95% CI, 0.924-0.970). In the test set, mean absolute error was 0.054 (95% CI, 0.048-0.061) and CS was 0.951 (95% CI, 0.924-0.970). Developed DL algorithm could predict the WBL ratio on knee standing AP alone with comparable accuracy as the degree primary physician can assess the alignment. It can be the basis for developing an automated lower limb alignment assessment tool that can be used easily and cost-effectively in primary clinics.
DENDRITIC ZINC DEPOSITION PROM FLOWING ACIDIC SOLUTIONS (1985)

This report covers two topics of research related to the operation and design of zinc/halogen batteries: (1) mass transfer and speciation in concentrated zinc halide electrolytes; (2) growth of dendritic zinc deposits under conditions of well-defined convection.Effective diffusivities have been determined for zinc in concentrated halide solutions supported by KCl.They are calculated from polarographic limiting currents, which are well-defined even in highly concentrated solutions.The diffusivities are practically identical for ZnCl2 and ZnBr2 but decrease strongly with increasing zinc concentration (range O.Ol-3M, with 3M KCl).A slight effect of pH suggests that hydrogen-zinc complexes participate in the discharge process at low pH.The speciation of ZnC1 2 solutions, with and without KCl as supporting electrolyte, has been analyzed.The complex ZnCl3-ion appears to be the dominant zinc species in supported solutions.The complexation of zinc causes a negative contribution to the limiting current in these solutions, since the migration flux of the complex anions opposes the diffusional flux toward the cathode.After correction for this complex migration effect, the effective diffusivities of zinc in supported ZnC1 2 solutions are in good agreement with recent data for molecular diffusivities in such solutions.Consequently, a combination of speciation and migration analysis can be applied fruitfully to analyze mass transport in zinc/halogen battery electrolytes.The growth rate of dendritic (nodular) deposits from concentrated zinc halide electrolytes was studied experimentally, using a rotating-concentric-cylinderelectrode (RCCE) cell.This cell, which has well-defined mass-transfer characteristics and uniform current distribution, was equipped for visual observation of the deposit and measurement of protrusion height.In the linear growth regime the growth rate was strongly increased by increasing convection, however, the induction time necessary for the onset of the linear growth regime was also increased.Variation of pH appeared to have little effect.The deposit morphology was strongly influenced by the ohmic resistance of the solution (primary current distribution).The role of gas bubbles in the initiation of profiles was demonstrated by the effect of clinging bubbles.Nonuniform corrosion of nodules by dissolved halogen or acid was shown to be an important influence on deposition morphology.
Synthesis and Biological Evaluation of Benzodioxanylpiperazine Derivatives as Potent Serotonin 5-HT1A Antagonists:  The Discovery of Lecozotan (2005)

A series of benzodioxanylpiperazine derivatives possessing a 4-aryl amide substituent was prepared and evaluated for 5-HT(1A) affinity and functional antagonist activity in vitro and in vivo. All of the compounds in this series possessed high affinity for the human 5-HT(1A) receptor and many displayed potent antagonist activity in vitro and varying degrees of intrinsic activity in vivo. Compound 11c (Lecozotan) was selected for further development and is currently in clinical trials.
Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases (2013)

Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases that act as key regulatory elements in cell cycle progression. We describe the development of highly potent diaminothiazole inhibitors of CDK2 (IC50 = 0.0009-0.0015 μM) from a single hit compound with weak inhibitory activity (IC50 = 15 μM), discovered by high-throughput screening. Structure-based design was performed using 35 cocrystal structures of CDK2 liganded with distinct analogues of the parent compound. The profiling of compound 51 against a panel of 339 kinases revealed high selectivity for CDKs, with preference for CDK2 and CDK5 over CDK9, CDK1, CDK4, and CDK6. Compound 51 inhibited the proliferation of 13 out of 15 cancer cell lines with IC50 values between 0.27 and 6.9 μM, which correlated with the complete suppression of retinoblastoma phosphorylation and the onset of apoptosis. Combined, the results demonstrate the potential of this new inhibitors series for further development into CDK-specific chemical probes or therapeutics.
<title>In-situ wafer contamination detection through rf-PCD Measurements</title> (1995)

Radio-frequency photoconductance decay (RF-PCD) is a contactless method of measuring minority carrier lifetime in silicon. Low detection limits and speed of measurement makes this method ideally suited for in-situ determination of silicon wafer passivation and contamination processes. Comparative measurements of copper contamination of silicon surfaces using RF- PCD and TXRF yield a detection limit of about 10<SUP>9</SUP> Cu/cm<SUP>2</SUP>. The fast detection of changes in surface defects enables the time resolved observation of surface passivation breakdown due to the exposure of the wafer to controlled atmospheres. While nitrogen does not attack the surface passivation, oxygen exposure results in immediate native oxide growth.
X‐ray Absorption Spectroscopy Study of Zinc Coordination in Tetanus Neurotoxin, Astacin, Alkaline Protease and Thermolysin (1996)

Tetanus and botulinum neurotoxins constitute a new group of Zn-endopeptidases which has been recently actively investigated with the purpose of correlating their biochemical properties to their neurobiocytosis inhibitory capacity. Crystallographic data show that Zn-endopeptidases are characterized by an active site with a Zn atom coordinated to two histidines and glutamate-bound water molecule. The two histidines and glutamate resides belong to the HEXXH motif which is characteristic of most Zn-endopeptidases. A forth metal ligand is a glutamate in thermolysin-like proteinases, but it is an histidine in the astacin family of proteinases and in alkaline protease. Astacin and alkaline protease possess a tyrosine as fifth Zn ligand, whose position in the case of alkaline protease could not be determined by X-ray crystallography. Not much is known about the atom arrangement around the active site in tetanus neurotoxin. In this work X-ray absorption spectroscopy has been used to obtain information on the Zn coordination mode in tetanus neurotoxin. The near-edge and extended fine-structure absorption spectra of this toxin are compared with those of astacin, alkaline protease and thermolysin. The present data and sequence information suggest a new pattern of Zn coordination in tetanus neurotoxin with one water molecule and three aromatic residues as metal ligands. These residues are the two histidines of the characteristic motif and a tyrosine which is tentatively identified with Tyr242, on the basis of sequence comparison and mutagenesis experiments. The mean distances of the Zn from the nearest coordinated atoms is reported. Our results indicate that alkaline protease, like astacin, also possesses a tyrosine as a fifth ligand.
A Quantum-Based Approach to Predict Primary Radiation Damage in Polymeric Networks (2020)

&lt;div&gt;Initial atomistic-level radiation damage in chemically reactive materials is thought to induce reaction cascades that can result in undesirable degradation of macroscale properties. Ensembles of quantum-based molecular dynamics (QMD) simulations can accurately predict these cascades, but extracting chemical insights from the many underlying trajectories is a labor-intensive process that can require substantial a priori intuition. We develop here a general and automated graph-based approach to extract all chemically distinct structures sampled in QMD simulations and apply our approach to predict primary radiation damage of polydimethylsiloxane (PDMS), the main constituent of silicones. A post-processing protocol is developed to identify underlying polymer backbone structures as connected components in QMD trajectories. These backbones form a repository of radiation-damaged structures. A scheme for extracting and updating a library of isomorphically distinct structures is proposed to identify the spanning set and aid chemical interpretation of the repository. The analyses are applied to ensembles of cascade QMD simulations in which the four element types in PDMS are selectively excited in primary knock-on atom events. Our approach reveals a much higher degree of combinatorial complexity in this system than was inferred through radiolysis experiments. Probabilities are extracted for radiation-induced network changes including formation of branch points, carbon linkages, cycles, bond scissions, and carbon uptake into the Si-O siloxane backbone network. The general analysis framework presented here is readily extendable to modeling chemical degradation of other polymers and molecular materials and provides a basis for future quantum-informed multiscale modeling of radiation damage. &lt;br&gt;&lt;/div&gt;
An Intronic Mutation is Associated with Prolactinoma in a Young Boy, Decreased Penetrance in his Large Family, and Variable Effects onMEN1 mRNAand Protein (2009)

Prolactinomas are rare tumors in prepubertal children. A prolactinoma in a young child may be due to sequence variants in genes that are known to cause these tumors ( MEN1, PRKAR1A, AIP). An 11-year-old boy with a macroprolactinoma was treated with cabergoline and the tumor receded. We studied the patient and his family for genetic causes of this tumor. No mutations were present in the coding sequence of PRKAR1A and AIP. A novel heterozygous substitution (IVS3-7 c>a) was identified in intron 3 of MEN1. We also found an additional PCR amplicon that incorporated the entire intron 3 of the gene (210 bp) in the patient's cDNA. The same amplicon was present with lower intensity in some of the control individuals who were not mutation carriers. Intron 3 harbors an in-frame stop codon and its incorporation is predicted to result in a prematurely terminated protein. We conclude that a novel MEN1 variation was identified in a young boy with prolactinoma and six of his relatives who did not present with prolactinoma or other MEN1 related symptoms. This novel MEN1 variation may be associated with low penetrance of the disease. The IVS3-7 c>a defect is suggested to be pathogenic because it is associated with lower menin levels in the cells of these patients, but its consequences may be mitigated by a variety of factors including changes in transcription and translation of the MEN1 gene.