gebhart/patrepeval huggingface dataset:
Quasirents, Influence and Organization Form (1986)

When changing jobs is costly, efficient employment arrangements are characterized by complex contracts, rather than simply wages. Under these contracts, workers are not generally fully compensated for the effects of post-employment events or decisions. As a consequence, if there is a central office executive with discretionary authority to make decisions, employees will be led to waste valuable time in attempts to influence his decisions. Efficient organization design balances these "influence costs" against the benefits of improved appraisal, coordination, and planning that such an executive can provide. Identifying influence costs requires first identifying the kinds of decisions about which employees will care. We identify several: with efficient employment contracts, employees prefer more on-the-job consumption and better opportunities to learn and display their abilities and to acquire human capital. They also prefer to occupy jobs where continuity of employment is particularly important to the employer, because such jobs carry higher wages. Applications of our perspective, which focuses on influence processes and the trade-off between influence costs and improved decisionmaking appears to have wide and fruitful application to questions or organization theory, industrial organization, contract theory, and related areas.
Trends in Kidney Transplant Outcomes in Older Adults (2014)

Despite a major increase in number of older adults transplanted and an expanding window of transplant eligibility, mortality and graft loss have decreased substantially for this recipient population. These trends are important to understand for patient counseling and transplant referral.
Tumor-Selective Response to Antibody-Mediated Targeting of αvβ3 Integrin in Ovarian Cancer (2008)

The alpha(v)beta(3) integrin is expressed on proliferating endothelial cells and some cancer cells, but its expression on ovarian cancer cells and its potential as a therapeutic target are unknown. In this study, expression of the alpha(v)beta(3) integrin on ovarian cancer cell lines and murine endothelial cells was tested, and the effect of a fully humanized monoclonal antibody against alpha(v)beta(3), Abegrin (etaracizumab), on cell invasion, viability, tumor growth, and the Akt pathway were examined in vitro and in vivo. We found that etaracizumab recognizes alpha(v)beta(3) on the ovarian cancer cell lines SKOV3ip1, HeyA8, and A2780ip2 (at low levels) but not on murine endothelial cells. Etaracizumab treatment decreased ovarian cancer proliferation and invasion. In vivo, tumor-bearing mice treated with etaracizumab alone gave variable results. There was no effect on A2780ip2 growth, but a 36% to 49% tumor weight reduction in the SKOV3ip1 and HeyA8 models was found (P < .05). However, combined etaracizumab and paclitaxel was superior to paclitaxel in the SKOV3ip1 and A2780ip2 models (by 51-73%, P < .001) but not in the HeyA8 model. Treatment with etaracizumab was then noted to decrease p-Akt and p-mTOR in SKOV3ip1, but not in HeyA8, which is Akt-independent. Tumors resected after therapy showed that etaracizumab treatment reduced the proliferating cell nuclear antigen index but not microvessel density. This study identifies tumor cell alpha(v)beta(3) integrin as an attractive target and defines the Akt pathway as a predictor of response to function-blocking antibody.
P2‐055: Aβ OLIGOMER ELIMINATION IMPROVES COGNITIVE AND MOTORIC IMPAIRMENT IN DIFFERENT ALZHEIMER'S DISEASE MOUSE MODELS AFTER ORAL ADMINISTRATION (2018)

Alzheimer's disease (AD), a progressive neurodegenerative disorder, is the most common form of dementia worldwide. Until now, no curative treatment is accessible. During the last years, our group developed compounds that directly eliminate toxic amyloid β oligomers, which are postulated to be responsible for the development and progression of AD. Here, we investigated the treatment efficacy of our most promising compound in various transgenic AD mouse models. Different AD mouse models were treated orally for several weeks with placebo or different doses of the compound. At the end of the treatment period, several behavioural assessments were conducted. Brains were analysed for changes in amyloid pathology, inflammation and neurodegeneration. After treatment, mice showed a significantly improved cognitive or motor performance compared to placebo controls. Treated non-transgenic littermates did not show abnormalities due to the treatment with the compound. We were able to show that the investigated compound does not only have a preventive but also a truly curative effect on cognitive performance. Moreover, it decelerates the neurodegenerative phenotype. Correlation of Aβ elimination in vivo and the reversal of cognitive deficits are in support of Aβ oligomers being relevant not only for disease development and progression, but also for Aβ oligomers as a promising target for the causal treatment of AD.
Practical Synthesis of α‐Trifluoromethylated Pyridines Based on Regioselective Cobalt‐Catalyzed [2+2+2] Cycloaddition using Trifluoromethylated Diynes with Nitriles (2021)

Regioselective cobalt-catalyzed [2+2+2] cycloaddition using fluorine-containing diynes with nitriles was described. Cycloaddition of fluorinated diynes with nitriles under the influence of CoCl<sub>2</sub>(phen), zinc bromide, and zinc dust in dichloroethane at 80°C for 3 h took place smoothly, exclusively affording the corresponding <i>α</i>-fluoroalkylated pyridines in excellent yields. In addition, dinitriles as substrate were also found to be suitable for this reaction, giving the corresponding fluoroalkylated bipyridine derivatives in excellent yields.
N-Phenylselenophthalimide. A useful reagent for the facile transformation of (1) carboxylic acids into either selenol esters or amides and (2) alcohols into alkyl phenyl selenides (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTN-Phenylselenophthalimide. A useful reagent for the facile transformation of (1) carboxylic acids into either selenol esters or amides and (2) alcohols into alkyl phenyl selenidesPaul A. Grieco, John Yan Jaw, D. A. Claremon, and K. C. NicolaouCite this: J. Org. Chem. 1981, 46, 6, 1215–1217Publication Date (Print):March 1, 1981Publication History Published online1 May 2002Published inissue 1 March 1981https://pubs.acs.org/doi/10.1021/jo00319a037https://doi.org/10.1021/jo00319a037research-articleACS PublicationsRequest reuse permissionsArticle Views911Altmetric-Citations89LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Normothermic Perfusion of Discarded Human Pancreases. (2014)

Introduction: Pancreas transplantation (solid organ or islets) is the most effective treatment for patients with progressive complications of diabetes, or patients with labile blood sugar control and hypoglycaemia unawareness. Increasing demand for transplants requires the use of more marginal donor organs, including those from DCD donors. However, the deleterious effects of cold ischaemia affect the viability of the organ and are exacerbated by prior injury. Currently there is no validated means to test the viability of the organ before transplantation. There is accumulating evidence of the benefits of a more physiological approach using continuous perfusion of an oxygenated, blood-based perfusate at normal body temperature. We describe here the practicality of normothermic ex-vivo perfusion of human pancreases. Methods: Human pancreases that were turned down by all transplant units have been utilised. A cardiopulmonary circuit consisting of oxygenator, heat exchanger, centrifugal pump, reservoir, flow probes and gate clamp is primed with research red cells and the temperature maintained at 38°C. The circuit is primed with antibiotics and heparin. A continuous infusion of heparin, prostacyclin and bicarbonate is provided. The arterial inflow of the pancreas is cannulated and venous outflow collected and recirculated. Effluent from the duodenal segment is collected and measured. Results: Using this circuit, it is possible to achieve stable normal arterial pressures and flows. During preservation, physiological flows and pressures are maintained in the splenic artery and the superior mesenteric artery by controlling the pump head speed and adjusting the proportional pinch valve on the bypass circuit. Serum amylase drops over the length of the perfusion whilst duodenal amylase production increases. Total protein levels gradually decrease suggesting a functioning organ. Discussion: This is the first demonstration of successful normothermic perfusion of the human pancreas. This has the potential to increase the viability, assessment and safety of donor organs in this expanding field. DISCLOSURES:Ravikumar, R.: Other, OrganOx, Consultant. Coussios, C.: Other, OrganOx, Technical Director. Friend, P.: Other, OrganOx, Medical Director.
LDRD final report on massively-parallel linear programming : the parPCx system. (2005)

This report summarizes the research and development performed from October 2002 to September 2004 at Sandia National Laboratories under the Laboratory-Directed Research and Development (LDRD) project ''Massively-Parallel Linear Programming''. We developed a linear programming (LP) solver designed to use a large number of processors. LP is the optimization of a linear objective function subject to linear constraints. Companies and universities have expended huge efforts over decades to produce fast, stable serial LP solvers. Previous parallel codes run on shared-memory systems and have little or no distribution of the constraint matrix. We have seen no reports of general LP solver runs on large numbers of processors. Our parallel LP code is based on an efficient serial implementation of Mehrotra's interior-point predictor-corrector algorithm (PCx). The computational core of this algorithm is the assembly and solution of a sparse linear system. We have substantially rewritten the PCx code and based it on Trilinos, the parallel linear algebra library developed at Sandia. Our interior-point method can use either direct or iterative solvers for the linear system. To achieve a good parallel data distribution of the constraint matrix, we use a (pre-release) version of a hypergraph partitioner from the Zoltan partitioning library. We describe the design and implementation of our new LP solver called parPCx and give preliminary computational results. We summarize a number of issues related to efficient parallel solution of LPs with interior-point methods including data distribution, numerical stability, and solving the core linear system using both direct and iterative methods. We describe a number of applications of LP specific to US Department of Energy mission areas and we summarize our efforts to integrate parPCx (and parallel LP solvers in general) into Sandia's massively-parallel integer programming solver PICO (Parallel Interger and Combinatorial Optimizer). We conclude with directions for long-term future algorithmic research and for near-term development that could improve the performance of parPCx.
Research on an Ultra-Short-Term Working Condition Prediction Method Based on a CNN-LSTM Network (2023)

Affected by factors such as complex production operation data, high dimensions, and weak regularity, the existing ultra-short-term working condition prediction method struggles to guarantee the prediction accuracy and operation speed. Therefore, we propose an ultra-short-term working condition prediction method based on a convolutional neural network (CNN) and a long short-term memory network (LSTM). Firstly, we use sliding window and normalized processing methods to carry out data processing, and use CNN to extract the characteristics of processed production operation data. Secondly, we then improve the LSTM gated structure and introduce L2 norm, learning the change law of the production operation data by means of the LSTM prediction layer, and then obtain the predicted value of the working condition. We use the Bayesian method to select the parameters of the CNN-LSTM model to improve the prediction accuracy. Finally, we apply our method to a real-world application to demonstrate that our ultra-short-term working condition prediction method achieves superior results for prediction accuracy and running speed when compared with other methods.
RiderS: Towards a Privacy-Aware Decentralized Self-Driving Ride-Sharing Ecosystem (2020)

Computer vision, machine learning, and decentralized applications are paving the way for a future where autonomous systems will be able to truly interact without humans in the loop. Though in its infancy, self-driving technologies are a prime example of this phenomena. This paper proposes RiderS, a novel privacy-first decentralized self-driving ride-sharing ecosystem, which consists of everything needed to allow autonomous/self-driving vehicles to participate in a decentralized ride-sharing economy. At its core, RiderS relies on a self-sovereign biometric solution, which leverages computer vision to register and authenticate users via a privacy-first biometric authentication algorithm. We then propose a novel decentralized architecture to support a self-sustained ride-sharing ecosystem. We propose a novel proof-of-matching geo-aware consensus algorithm, which is used to validate, and reward self-driving vehicles. The key concept being that each vehicle leverages its built-in compute power to assist in verifying transactions in order to keep the ecosystem in check while being rewarded for the work. Experimental results show that we can perform about 10K Matches per second (KMs) using an NVIDIA Jetson AGX Xavier development kit. We analyzed the privacy aspects as well as the accuracy of our biometric solution with good matching rates. Furthermore, we evaluated the performance and scalability of our proposed consensus algorithm and compared it to similar proof-of-work based blockchains yielding promising results. We modeled our ride-sharing ecosystem using published statistics from Uber and show that we can support Uber-scale ride-sharing using our geo-location aware consensus algorithm through a what-if simulated exercise.
Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome (2005)

A characteristic finding of childhood HIV-associated hemolytic uremic syndrome (HIV-HUS) is the presence of endothelial injury and microcystic tubular dilation, leading to a rapid progression of the renal disease. We have previously shown that a secreted fibroblast growth factor-binding protein (FGF-BP) is upregulated in kidneys from children affected with HIV-HUS and HIV nephropathy. Here, we sought to determine the potential role of FGF-BP in the pathogenesis of HIV-HUS. By immunohistochemical and in situ hybridization studies, we observed FGF-BP protein and mRNA upregulation in regenerating renal tubular epithelial cells from kidneys of HIV-Tg26 mice with late-stage renal disease, that is, associated with the development of microcystic tubular dilatation and accumulation of FGF-2. Moreover, FGF-BP increased the FGF-2-dependent growth and survival of cultured primary human renal glomerular endothelial cells and enhanced FGF-2-induced MAPK/ERK2 activation, as well as the proliferation of immortalized GM7373 endothelial cells. We propose that HIV-Tg26 mice are a clinically relevant model system to study the role of FGF-BP in the pathogenesis of HIV-associated renal diseases. Furthermore, the upregulation of FGF-BP by regenerating renal tubular epithelial cells may provide a mechanism by which the regenerative and angiogenic activity of FGF-2 in renal capillaries can be modulated in children with HIV-HUS and other renal disease.
Interferon-gamma in the prevention of severe burn-related infections (1998)

IFN-gamma did not protect burn patients from infections or decrease the mortality from infections.
L/MRP: A Buffer Management Strategy for Interactive Continuous Data Flows in a Multimedia DBMS (1995)

Multimedia applications demand specific support from database management systems due to the characteristics of multimedia data and their interactive usage. This includes integrated support for high--volume and time--dependent (continuous) data types like audio and video. One critical issue is to provide handling of continuous data streams including buffer management as needed for multimedia presentations. Buffer management strategies for continuous data have to consider specific requirements like providing for continuity of presentations, for immediate continuation of presentations after frequent user interactions by appropriate buffer resource consumption. Existing buffer management strategies do not sufficiently support the handling of continuous data streams in highly interactive multimedia presentations. In this paper we present the &amp;quot;least/most relevant for presentation&amp;quot; (L/MRP)buffer management strategy which considerspresentation specific informationin order to provide an optimi...
In vitroscreening for chemokine antagonists (2009)

We discuss the rationale for continuing, after several failures, targeting chemokine receptors and how screening may change with the increasing evidence of dimerization of chemokine receptors.
PI-RADS® Category as a Predictor of Progression to Unfavorable Risk Prostate Cancer in Men on Active Surveillance (2020)

PI-RADS lesion categories at baseline multiparametric magnetic resonance imaging during active surveillance enrollment can be used to predict cancer progression to GG3 or greater on active surveillance. This information, along with other clinical data, can better assist urologists in identifying and managing patients appropriate for active surveillance.
Waveguide-based ultrasonic and far-field electromagnetic sensors for downhole reservoir characterization. (2010)

This report summarizes the first year research and development effort leading to development of high-temperature sensors for enhanced geothermal systems. It covers evaluation of ultrasonic and electromagnetic (EM) techniques applied to temperature measurement and flow characterization. On temperature measurement, we have evaluated both microwave radiometry and ultrasonic techniques for temperature gradient and profile measurements. Different antenna designs are evaluated and array loop antenna design is selected for further development. We have also evaluated ultrasonic techniques for total flow characterization, which includes using speed of sound to determine flow temperature, measuring acoustic impedance to estimate fluid density, and using cross-correlation technique to determine the mass flow rate. Method to estimate the flow enthalpy is briefly discussed. At end, the need and proposed techniques to characterize the porosity and permeability of a hot dry rock resource are presented.
Photosensitive Characteristics of Dopant‐Free, Ultraviolet‐Sensitive Calcium Aluminate Glasses (1987)

Calcium aluminate glasses show high sensitivity to ultraviolet radiation without the doping of optically active components. In this paper, photosensitive characteristics and the cause of UV‐induced coloring were investigated for these glasses. Ultraviolet rays below 270 nm were effective for inducing the coloring. The most effective wavelength agreed with that of the apparent absorption edge. In the ternary system with SiO 2 or GeO 2 , the sensitivity was monotonically reduced with the amount of the third component and almost vanished for the compositions containing 40 mol%. On the basis of the establishment of a close correlation between two optical absorption bands and two electron spin resonance signals induced by UV illumination, the UV‐induced coloring was concluded to be due to the emergence of an aluminum‐oxygen hole center (Al‐OHC) and an ozonide (O 3 ‐ ).
Heat set creases in polyethylene terephthalate (PET) sheets to enable origami-based applications (2019)

Abstract Polyethylene terephthalate (PET) sheets show promise for application in origami-based engineering design. Origami-based engineering provides advantages that are not readily available in traditional engineering design methods. Several processing methods were examined to identify trends and determine the effect of processing of PET sheets on the crease properties of origami mechanisms in PET. Various annealing times, temperatures, and cooling rates were evaluated and data collected for over 1000 samples. It was determined that annealing temperature plays the largest role in crease response. An increase in the crystallinity of a PET sheet while in the folded state likely increases the force response of the crease in PET sheets. An annealing time of at least 60 min at 160 °C–180 °C with a quick cooling results in a high force response in the crease. The effectiveness of the processing methods was demonstrated in several origami patterns of various complexities.
Highlighted Document Image Classification (2021)

There are many existing document image classification researches, but most of them are not designed for use in constrained computer resources, like printers, or focused on documents with highlighter pen marks. To enable printers to better discriminate highlighted documents, we designed a set of features in CIE Lch(a* b*) space to use along with the support vector machine. The features include two gamut-based features and six low-level color features. By first identifying the highlight pixels, and then computing the distance from the highlight pixels to the boundary of the printer gamut, the gamut-based features can be obtained. The low-level color features are built upon the color distribution information of the image blocks. The best feature subset of the existing and new features is constructed by sequential forward floating selection (SFFS) feature selection. Leave-one-out cross-validation is performed on a dataset with 400 document images to evaluate the effectiveness of the classification model. The cross-validation results indicate significant improvements over the baseline highlighted document classification model.
ChemInform Abstract: Total Synthesis of PI‐091 (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Soft drinks catalyzed hydrolysis and alcoholysis of epoxides (2008)

Commonly consumed soft drinks have been utilized for the first time for the efficient hydrolysis and alcoholysis of epoxides furnishing the corresponding 1,2-diols and ii-alkoxyalcohols respectively.
The Effects of Infliximab Therapy on Health-Related Quality of Life in Ulcerative Colitis Patients (2007)

Infliximab therapy substantially improved HRQL in patients with UC. This benefit was sustained through 1 yr with maintenance infliximab therapy.