gebhart/patrepeval huggingface dataset:
On graphene-based THz plasmonic nano-antennas (2016)

Graphene-enabled wireless communications create an innovative archetype proposed to implement wireless communications at the nanoscale. Indeed, graphene-based nano-antennas, or graphennas, are few micrometers in size. Such antennas have been predicted to radiate electromagnetic waves at the Terahertz band. Hence, they do not only provide better integrability for future miniaturized wireless systems but also represent an enabling technology for applications such as wireless nano-sensor networks and Internet-of-Things (IoT). This paper surveys the existing research which investigates the state-of-art of graphene-based plasmonic nano-antennas. The paper focuses on the propagation of Surface Plasmon Polariton (SPP) waves since they set up the main characteristics of these antennas. Various fundamental properties of plasmonic antennas are also discussed providing useful guidelines for future designers of these antennas. The paper also addresses the future research areas of graphene-based Terahertz nano-antennas.
Developments in optical coherence microscopy (2010)

Optical Coherence Microscopy (OCM) utilizes a high NA microscope objective in the sample arm to achieve an axially and laterally high resolution OCT image. An increase in NA, however, leads to a dramatically decreased depth of focus (DOF), and hence shortens the imaging depth range so that high lateral resolution is maintained only within a small depth region around the focal plane. One solution to increase the depth of imaging while keeping a high lateral resolution is dynamic-focusing. Utilizing the voltage controlled refocus capability of a liquid lens, we have recently presented a solution for invariant high resolution imaging using the liquid lens embedded within a fixed optics hand-held custom microscope designed specifically for optical imaging systems using a broadband light source centered at 800 nm with a 120 nm bandwidth. Subsequently, we have developed a Gabor-Domain Optical Coherence Microscopy (GD-OCM) that utilizes the high speed imaging of spectral domain OCT, the high lateral resolution of OCM, and the ability of real time refocusing of our custom design variable focus objective. Finally, key developments in Phase-Resolved Doppler OCT (PR-DOCT) are key enablers to combine high-resolution structural imaging with functional imaging. In this paper we review achievements in GD-OCM and detail how portions of in-focus cross-sectional images can be extracted and fused to form an invariant lateral resolution image with multiple cross-sectional images acquired corresponding to a discrete refocusing step along depth enabled by the varifocal device. We demonstrate sub-cellular resolution imaging of an African frog tadpole (Xenopus Laevis) taken from a 500 &mu;m &times; 500 &mu;m cross-section as well as cellular imaging in in vivo skin. Finally, A novel dual-detection full-range Fourier-domain optical coherence tomography system was developed that provides 7 &mu;m axial resolution (in air) at about 90 kHz axial scan rate for mirror-image phase resolved Doppler imaging in an African frog tadpole and an in vivo human finger.
CSCW—what does it mean? (Panel Session) (1988)

No abstract available.
Determination of Binding Constants of Ligands to Proteins by Affinity Capillary Electrophoresis: Compensation for Electroosmotic Flow (1994)

This paper describes the estimation of binding constants (Kb) between carbonic anhydrase B (CAB, EC 4.2.1.1, from bovine erythrocytes) and charged benzenesulfonamides by affinity capillary electrophoresis (ACE) under conditions in which the migration time is affected by changes in electroosmotic flow and by nonspecific interactions accompanying changes in the concentration of ligand. Comparisons of values of migration times of the protein of interest, and of "noninteracting" marker proteins, with those of a neutral internal standard provide the basis for corrections for variable electroosmotic flow; these corrections make possible the estimation of Kb and its uncertainty even in the presence of substantial variations in electroosmotic flow.
The Importance of Purkinje Activation in Long Duration Ventricular Fibrillation (2014)

These extracellular and intracellular findings about activation support the hypothesis that Purkinje activation propagates to stimulate WM during sinus rhythm, pacing, and LDVF.
Physical Data Warehousing Design (2005)

Recently, organizations have increasingly emphasized applications in which current and historical data are analyzed and explored comprehensively, identifying useful trends and creating summaries of the data in order to support high-level decision making. Every organization keeps accumulating data from different functional units, so that they can be analyzed (after integration), and important decisions can be made from the analytical results. Conceptually, a data warehouse is extremely simple. As popularized by Inmon (1992), it is a “subject-oriented, integrated, time-invariant, non-updatable collection of data used to support management decision-making processes and business intelligence”. A data warehouse is a repository into which are placed all data relevant to the management of an organization and from which emerge the information and knowledge needed to effectively manage the organization. This management can be done using data-mining techniques, comparisons of historical data, and trend analysis. For such analysis, it is vital that (1) data should be accurate, complete, consistent, well defined, and time-stamped for informational purposes; and (2) data should follow business rules and satisfy integrity constraints. Designing a data warehouse is a lengthy, time-consuming, and iterative process. Due to the interactive nature of a data warehouse application, having fast query response time is a critical performance goal. Therefore, the physical design of a warehouse gets the lion’s part of research done in the data warehousing area. Several techniques have been developed to meet the performance requirement of such an application, including materialized views, indexing techniques, partitioning and parallel processing, and so forth. Next, we briefly outline the architecture of a data warehousing system.
Cycloruthenated Compounds as Efficient Catalyst for Asymmetric Hydride Transfer Reaction (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Francisella tularensis Schu S4 Lipopolysaccharide Core Sugar and O-Antigen Mutants Are Attenuated in a Mouse Model of Tularemia (2014)

The virulence factors mediating Francisella pathogenesis are being investigated, with an emphasis on understanding how the organism evades innate immunity mechanisms. Francisella tularensis produces a lipopolysaccharide (LPS) that is essentially inert and a polysaccharide capsule that helps the organism to evade detection by components of innate immunity. Using an F. tularensis Schu S4 mutant library, we identified strains that are disrupted for capsule and O-antigen production. These serum-sensitive strains lack both capsule production and O-antigen laddering. Analysis of the predicted protein sequences for the disrupted genes (FTT1236 and FTT1238c) revealed similarity to those for waa (rfa) biosynthetic genes in other bacteria. Mass spectrometry further revealed that these proteins are involved in LPS core sugar biosynthesis and the ligation of O antigen to the LPS core sugars. The 50% lethal dose (LD50) values of these strains are increased 100- to 1,000-fold for mice. Histopathology revealed that the immune response to the F. tularensis mutant strains was significantly different from that observed with wild-type-infected mice. The lung tissue from mutant-infected mice had widespread necrotic debris, but the spleens lacked necrosis and displayed neutrophilia. In contrast, the lungs of wild-type-infected mice had nominal necrosis, but the spleens had widespread necrosis. These data indicate that murine death caused by wild-type strains occurs by a mechanism different from that by which the mutant strains kill mice. Mice immunized with these mutant strains displayed >10-fold protective effects against virulent type A F. tularensis challenge.
Bright Lu2O3:Eu Thin‐Film Scintillators for High‐Resolution Radioluminescence Microscopy (2015)

The performance of a new thin-film Lu<sub>2</sub> O<sub>3</sub> :Eu scintillator for single-cell radionuclide imaging is investigated. Imaging the metabolic properties of heterogeneous cell populations in real time is an important challenge with clinical implications. An innovative technique called radioluminescence microscopy has been developed to quantitatively and sensitively measure radionuclide uptake in single cells. The most important component of this technique is the scintillator, which converts the energy released during radioactive decay into luminescent signals. The sensitivity and spatial resolution of the imaging system depend critically on the characteristics of the scintillator, that is, the material used and its geometrical configuration. Scintillators fabricated using conventional methods are relatively thick and therefore do not provide optimal spatial resolution. A thin-film Lu<sub>2</sub> O<sub>3</sub> :Eu scintillator is compared to a conventional 500 μm thick CdWO<sub>4</sub> scintillator for radioluminescence imaging. Despite its thinness, the unique scintillation properties of the Lu<sub>2</sub> O<sub>3</sub> :Eu scintillator allow us to capture single-positron decays with fourfold higher sensitivity, which is a significant achievement. The thin-film Lu<sub>2</sub> O<sub>3</sub> :Eu scintillators also yield radioluminescence images where individual cells appear smaller and better resolved on average than with the CdWO<sub>4</sub> scintillators. Coupled with the thin-film scintillator technology, radioluminescence microscopy can yield valuable and clinically relevant data on the metabolism of single cells.
Molybdenum-99 Isotope Production Preparation at Sandia National Laboratories (1998)

`Q&c M. J. McDonald, S. D. Carson, S. W. Longley, E. J. Parma, M. E. Vern `~ I@ .,., Sandia National Laboratories*, P. .0. Box 5800, Albuquerque, NM, 8 W? 1$ tl?;:q `f. (3 . 8 /'~ Abstract This report was prepared as an account of work sponsored byanagency of the United States Government. Neither the United States Government nor any agency thereof, nor any of their employees, make any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States Government or any agency thereof. The views and opinions of authors expressed herein do not necessarily state or reflect those of the United States Government or any agency thereof. loading on the Cintichem targets. These tests were designed to gain process knowledge prior to processing an irradiated target. The chemical separation tests were performed in a fime hood During cold testing, several tests were performed on individual components of the process to complete, a series of `hot' tests was designed to process irradiated targets. These were designed to optimize the process, identify problems prior to processing higher inventory targets, and to the shielded containment box (SCB). Table 1 is a summary of the tests performed prior to the Test Target Power Post irradiation Total inventory 99M0 inventory (kW)/ Irradiation decay (hrs) (TBq*) /decay (TBq)/decay Time (hrs) inventory (TBq) inventory(TBq) in the processing boxes as color comparisons. Product quality control testing was conducted for all the tests and the results were compared to The production process generates a high activity acidic liquid waste. Several waste stabilization processing box. The cement, in addition to stabilizing the waste, neutralized the waste resulting The processing hardware and fixtures were developed in parallel to the cold tests and tested in a that expected during processing. During processing, precautions will be taken to minimize the Island incident. The facility consisted of shielded glove boxes, unshielded glove box lines and the the facility for production operations; the glove box lines and shielded glove boxes, all the new configuration will have six windows, four extraction boxes and a waste packaging box on the shielding. The walls and windows of the processing boxes will have the equivalent 150 of the purification box will be considerably less than the processing boxes with dose being from only `gMo. The increased wall thickness will reduce the dose levels to boxes will have under the box transport systems to move material into and out of the boxes. prior to FDA requiring process validation and, consequently, had not pertlormed a process
Probing the “Message:Address” Sites for Chemoattractant Binding to the C5a Receptor (1995)

The C5a anaphylatoxin ligand-receptor interaction on polymorphonuclear granulocytes stimulates chemotaxis, degranulation, and the oxidative burst. The receptor is a member of the large G-protein-coupled family. The ligand is a cationic peptide of 72 amino acids derived from the C5 component of complement and has been shown to have a number of structural requirements for interaction with the receptor. In order to probe the potential interaction sites between ligand and receptor, we constructed a series of mutated receptor molecules, targeting cysteines, prolines, and additional amino acids of interest because of combinations of charge or hydrophobicity and putative location with respect to the membrane. Transfected mutant receptors were analyzed for cell surface expression, ligand binding, and ligand-activated phospholipase C activity. The receptors created can be placed generally in four distinct classes: those which bind and signal like the natural receptor; those which bind but fail to transduce signals; those which are expressed but neither bind nor transduce signal; and those which are not expressed at the cell surface.
Designing effective interfaces for process management systems (1995)

Traditionally, control system user interface designers have focused on controlling the process, so operators were forced to handle other responsibilities using additional terminals or computers. The result was a control room filled with different pieces of hardware, each with its own user interface. Advances in hardware and software have helped solve the problems of multiple user interfaces. New user interfaces based on a single set of standards make it possible to more effectively integrate process control data with other information needed to support decision making. In designing such systems, the different types of information that the systems are required to handle place special demands on the designers. Important considerations include the proper use of display elements (such as windows, menus, and buttons), real-time constraints (such a system response times, non-occluded display elements for critical information, and alarm annunciation), and efficient window management. This paper addresses some of the design criteria for such process management systems and proposes solutions to the identified design requirements.
Introduction to the Controversy Regarding the Management of Intracranial Aneurysms (2003)

Washington University School of Medicine St. Louis, Missouri University of Cambridge Addenbrooke's Hospital Cambridge, England
Unified Theory of Oscillator Phase Noise I: White Noise (2013)

The spectral purity of every oscillator system is limited by phase noise. In this work, we extend the techniques previously used to analyze phase noise in lasers to develop an intuitive, yet powerful description of phase noise in an electromagnetic oscillator for the case when the oscillating field is sinusoidal and perturbed by white noise. The developed theory is general and unifies the understanding of phase noise in both electrical and optical oscillators. Our approach is based on partitioning the noise among the modes of the oscillator, which is analogous to the approach used to analyze phase noise in laser cavities, but has not been previously considered for electrical oscillators. We show that oscillator phase noise depends only on the oscillating power, injected noise, and round-trip delay. This result provides a theoretical foundation to and expands upon the predictions provided by Leeson's well-known empirical oscillator phase-noise model. To validate the developed theory, we compare the predicted phase noise to the experimentally measured phase noise of both a simple electrical oscillator and a hybrid opto-electronic oscillator and show excellent agreement across a wide range of operation.
ChemInform Abstract: An Efficient Synthesis of (2S,6S)‐ and meso‐Diaminopimelic Acids via Asymmetric Hydrogenation. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Electroconvulsive seizure-induced changes in gene expression in the mouse hypothalamic paraventricular nucleus (2013)

Electroconvulsive therapy is an effective and rapid treatment for depression. In patients with depression, the function of the paraventricular nucleus of the hypothalamus (PVN) is frequently altered. Electroconvulsive seizure (ECS), which is a model of electroconvulsive therapy, upregulates the expression of c-fos in the PVN of animal models. Therefore, we hypothesized that ECS alters gene expression and function in the PVN. The PVN was microdissected from mouse brain sections following ECS treatment, and total RNA was analyzed by microarray. Two hours after ECS, the levels of expression of 2.6% (589 genes) of the genes showed a greater than 2-fold decrease and 0.9% (205 genes) showed a greater than 2-fold increase. Among these genes, 72 of the downregulated genes and 12 of the upregulated genes have been proposed to be associated with psychiatric disorders, such as depression, by knowledge database analyses. The groups of downregulated genes included neuropeptides (Cck), kinases (Prkcb, Camk2a), transcription factors (Tcf4), and transporters (Aqp4), and these have been suggested to be associated with psychiatric disorders and/or PVN function. The results of the present study indicated that ECS treatment could modulate PVN functions through altered gene expression, which may contribute to its antidepressant effects.
A New Method of Backup Cutter Layout to Extend Bit Life Without Sacrificing Rate of Penetration (2017)

Abstract This paper discusses a new and general method of backup cutter layout to extend bit life without sacrificing rate of penetration and two field case studies. This method includes the following aspects: Ensuring backup cutters do not cut or only partially cut when their primary cutters experience little to no wear and when the depth of cut of the bit does not exceed an expected value. This aspect is enabled by allowing backup cutters to have a minimal critical depth of cut that is greater than the depth of cut of the primary cutters.Ensuring backup cutters act as major cutters when the primary cutters' wear depth is equal to or greater than the underexposure of the backup cutters. This aspect is enabled by allowing each backup cutter be rotationally behind its primary cutter by approximately 180° or greater. The underexposure of each backup cutter relative to its primary cutter is carefully calculated based on the primary cutter's wear and drilling slope.
A 65nm SRAM achieving 250mV retention and 350mV, 1MHz, 55fJ/bit access energy, with bit-interleaved radiation Soft Error tolerance (2012)

An Ultra Low Voltage memory was fabricated in 65nm CMOS with an optimized 10 transistors bitcell. It withstands 1.2V down to 0.35V voltage range, achieves 55fJ/bit energy access at 0.35V and exhibits wafer level yield above 95% at 0.4V, 1MHz. Packaged parts test show 0.32V minimum operating voltage at 500kHz, up to 17X energy gain per operation and 250mV retention voltage at 125°C. The memory terrestrial radiation Soft Error Rate was characterized with no multibit errors reported, enabling radiation reliability through bit-interleaving combined with error correcting code.
Data from The miR-17/92 Polycistron Is Up-regulated in Sonic Hedgehog–Driven Medulloblastomas and Induced by N-myc in Sonic Hedgehog–Treated Cerebellar Neural Precursors (2023)

&lt;div&gt;Abstract&lt;p&gt;Medulloblastoma is the most common malignant pediatric brain tumor, and mechanisms underlying its development are poorly understood. We identified recurrent amplification of the &lt;i&gt;miR-17/92&lt;/i&gt; polycistron proto-oncogene in 6% of pediatric medulloblastomas by high-resolution single-nucleotide polymorphism genotyping arrays and subsequent interphase fluorescence &lt;i&gt;in situ&lt;/i&gt; hybridization on a human medulloblastoma tissue microarray. Profiling the expression of 427 mature microRNAs (miRNA) in a series of 90 primary human medulloblastomas revealed that components of the miR-17/92 polycistron are the most highly up-regulated miRNAs in medulloblastoma. Expression of miR-17/92 was highest in the subgroup of medulloblastomas associated with activation of the sonic hedgehog (Shh) signaling pathway compared with other subgroups of medulloblastoma. Medulloblastomas in which miR-17/92 was up-regulated also had elevated levels of MYC/MYCN expression. Consistent with its regulation by Shh, we observed that Shh treatment of primary cerebellar granule neuron precursors (CGNP), proposed cells of origin for the Shh-associated medulloblastomas, resulted in increased miR-17/92 expression. In CGNPs, the Shh effector N-myc, but not Gli1, induced miR-17/92 expression. Ectopic miR-17/92 expression in CGNPs synergized with exogenous Shh to increase proliferation and also enabled them to proliferate in the absence of Shh. We conclude that miR-17/92 is a positive effector of Shh-mediated proliferation and that aberrant expression/amplification of this miR confers a growth advantage to medulloblastomas. [Cancer Res 2009;69(8):3249–55]&lt;/p&gt;&lt;/div&gt;
Outcomes of Tofacitinib Dose Reduction in Patients with Ulcerative Colitis in Stable Remission from the Randomised RIVETING Trial (2020)

Most patients in stable remission on 10 mg BID maintenance therapy maintained remission following dose de-escalation. For patients who dose de-escalated, those in deep endoscopic remission and those without prior TNFi failure were more likely to maintain remission. Efficacy data were limited to the first 6 months; a longer duration of follow-up during RIVETING will further characterise the impact of dose reduction on maintenance of remission. Safety findings were consistent with the established safety profile of tofacitinib.