gebhart/patrepeval huggingface dataset:
Modulation of mucosal effector and regulatory T cell responses by Helicobacter pylori (63.6) (2011)

Abstract Helicobacter pylori is a gram-negative, microaerophilic bacterium that colonizes the gastric mucosa and a leading cause of gastritis, peptic ulcer and gastric cancer. While dysregulated immune responses contribute to H. pylori-mediated pathogenesis, its immunoregulatory mechanisms are incompletely understood. To characterize the mechanisms of immune modulation by H. pylori we have performed dose-titration and time-course studies in mice infected with H. pylori strain 26695. Our dose-titration results indicate an increase in the percentages of INFγ+Tbet+ Th1 cells, lymphocytic infiltration into the gastric lamina propria, and disease activity with increasing concentrations of the H. pylori infectious dose (i.e., 106, 108 and 1010 cfu/ml). The profiling of T cell responses in the gastric lymph nodes (GLN) over time illustrates an initial increase in CD4+INFγ+Tbet+ (Th1 cells) on day 7 post-infection followed by a predominant peak of CD4+IL10+ T cells and smaller but significant peak of CD4+IL17+ T cells on day 14 post-infection. In conclusion, gastric H. pylori infection in mice induced mucosal effector Th1 and Th17 responses that were paralleled by strong regulatory responses, thereby lending support to importance of characterizing effector and regulatory networks to better comprehend microbial pathogenesis at the site of infection.
Factor IXa Inhibition by Protease Nexin-2/Amyloid .beta.-Protein Precursor on Phospholipid Vesicles and Cell membranes (1995)

Protease nexin-2/amyloid beta-protein precursor (PN-2/A beta PP) is a Kunitz-type protease inhibitor which has been shown to be a tight-binding inhibitor of enzymes, factors XIa and IXa (FIXa), suggesting a role for this protein in hemostasis. Since coagulant reactions are modulated on biologic surfaces, we investigated how 25:75 (mol/mol) phosphatidylserine/phosphatidylcholine vesicles (PSPC), thrombin-activated platelets, or umbilical vein endothelial cells influence inactivation of FIXa by PN-2/A beta PP. The Km of human or porcine FIXa activation of human factor X in the presence of PSPC, activated platelets, or endothelial cells in the absence or presence of thrombin-activated factor VIII (FVIIIa) was similar, (0.05-0.39 microM). The presence of FVIIIa increased the catalytic efficiency (kcat/Km ratio) of human and porcine factor IXa's activation of factor X 4952-406-fold, respectively. In the presence of PSPC, the Ki of human and porcine FIXa inhibition by PN-2/A beta PP was Ki = 1.9 x 10(-9) M and 5.8 x 10(-9) M, respectively. After the addition of FVIIIa to the reaction, the Ki for both human and porcine FIXa inhibition by PN-2/A beta PP on PSPC increased 13- and 4-fold to Ki = 2.5 x 10(-8) M and 2.4 x 10(-8) M, respectively. These Ki for inhibition of human FIXa on phospholipid vesicles by PN-2/A beta PP were similar when factor X activation was measured by chromogenic or activation peptide release assays. FVIIIa reduced the inhibition of FIXa by PN-2/A beta PP only in the presence of PSPC.(ABSTRACT TRUNCATED AT 250 WORDS)
The SYNTAX score on its way out or … towards artificial intelligence: part I (2020)

The SYNTAX score on its way out or
Selective Attention Impairments in Alzheimer's Disease: Evidence for Dissociable Components. (2004)

Tasks emphasizing 3 different aspects of selective attention-inhibition, visuospatial selective attention, and decision making-were administered to subjects with mild Alzheimer's disease (AD) and to healthy elderly control (HEC) subjects to determine which components of selective attention were impaired in AD subjects and whether selective attention could be dissociated into different components. The tasks were administered with easy versus hard levels of difficulty to assess proportional slowing as the key variable across tasks. The results indicated that the inhibitory and visual search tasks showed greater proportional slowing in subjects with AD than in HEC subjects, and that the task involving inhibition was significantly more affected in subjects with AD. Furthermore, there were no significant intertask correlations, and the results cannot be explained simply in terms of generalized cognitive slowing. These results provide evidence that inhibition is the most strikingly affected aspect of selective attention that is observed to be impaired in early stages of AD.
Business insight toolkit: Flexible pre-requirements modeling (2009)

Pre-requirements analysis requires modeling tools with unprecedented flexibility. The Business Insight Toolkit (BITKit) is a prototype of a new kind of modeling tool, aimed at offering the flexibility of office tools along with many of the advantages of modeling tools.
The European Competence Network on Mastocytosis (ECNM). (2004)

The European Competence Network on Mastocytosis (ECNM) is a Europe-wide, multinational cooperative approach attempting to improve recognition, diagnosis, and therapy of mastocytosis. The network is composed of local centers, physicians, and scientists who have dedicated their work to patients with mastocytosis. However, because of the rarity and complexity of the disease, each single component in the network alone would fail to meet important demands and to reach solid conclusions in this field of applied medicine. The ECNM represents an attempt to overcome this restriction as a cooperative multicenter platform that should serve as an important basis for the development of new therapeutic strategies and diagnostic concepts, and for the standardization of techniques used to determine diagnostic and prognostic parameters. Moreover, using future central databases and registries, a suitable infrastructure for the development of co-operative multicenter clinical trials will be established. In addition, the ECNM is dedicated to provide the best available information about the disease to patients and physicians.
Human osteoclast-like cells recognize laminin via an RGD independent mechanism. (1993)

Interactions between cells from human giant cell tumors of bone and the extracellular matrix protein laminin were studied. Cells were capable of recognizing this substratum via a RGD-independent mechanism. Recognition induces adhesion and spreading onto laminin. This protein triggered the release of cellular FN which in turn enhanced recruitment of the beta 1 chain-containing integrin receptor.
Total Synthesis of Brevetoxin B. 2. Second Generation Strategies and Construction of the Dioxepane Region [DEFG] (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal Synthesis of Brevetoxin B. 2. Second Generation Strategies and Construction of the Dioxepane Region [DEFG]K. C. Nicolaou, E. A. Theodorakis, F. P. J. T. Rutjes, M. Sato, J. Tiebes, X.-Y. Xiao, C.-K. Hwang, M. E. Duggan, Z. Yang, and Cite this: J. Am. Chem. Soc. 1995, 117, 41, 10239–10251Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://pubs.acs.org/doi/10.1021/ja00146a009https://doi.org/10.1021/ja00146a009research-articleACS PublicationsRequest reuse permissionsArticle Views1351Altmetric-Citations86LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information Get e-Alerts
Decoupling the Effects of the Amyloid Precursor Protein from Amyloid-β Plaques on Axonal Transport Dynamics in the Living Brain (2020)

Amyloid precursor protein (APP) is the precursor to A plaques. The cytoplasmic domain of APP mediates attachment of vesicles to molecular motors for axonal transport. In APP-KO mice transport of Mn 2+ is decreased. In old transgenic mice expressing mutated human (APP SwInd ) linked to Familial Alzheimer's Disease, with both expression of APP SwInd and plaques, the rate and destination of Mn 2+ axonal transport is altered, as detected by time-lapse manganese-enhanced magnetic resonance imaging (MEMRI) of the brain in living mice. To determine the relative contribution of expression of APP SwInd versus plaque on transport dynamics, we developed a Tet-off system to decouple expression of APP SwInd from plaque, and then studied hippocampal to forebrain transport by MEMRI. Three groups of mice were
Direct Amination of Cobaltocenium Hexafluoridophosphate via Vicarious Nucleophilic Substitution (2019)

In this communication we report a convenient, as short as possible synthesis of aminocobaltocenium hexafluoridophosphate, a very useful compound for further functionalization in cobaltocenium chemistry. Via vicarious nucleophilic substitution of hydrogen of cobaltocenium hexafluoridophosphate with 1,1,1-trimethylhydrazinium iodide as nucleophile bearing its own leaving group, a one-step amination of cobaltocenium in 50% isolated yield is possible, a major improvement over the standard multistep procedure involving common Curtius rearrangement chemistry.
Phosphorus-based fire retardants for polybutylene succinate: investigation of the gas phase (2018)

International audience
Covariance-Based Transmission Power Control for Estimation over Wireless Sensor Networks (2018)

In this study, we would like to design a transmission power control mechanism for minimizing the transmit power of a wireless sensor node subject to a constraint on the quality of estimation at a remote estimator. In particular, we measure the estimation distortion by a mean square error function, and model the transmit power as a function of the packet success rate using the IEEE 802.15.4 standard which was formed for the specification of low-data-rate and low-power wireless communication. We formulate the problem with an infinite horizon discounted cost function. We show that there is a separation between the designs of the optimal estimator and optimal transmit power policy. Then, we use dynamic programming to characterize the optimal transmit power policy in terms of the estimation error covariance. Finally, we propose approximate value iteration as an approximation algorithm to calculate a near-optimal transmit power policy.
ChemInform Abstract: Synthesis of 1‐Aryl‐3,3,3‐trifluoro‐1‐propynes and 3,5‐Diaryl‐4‐trifluoromethylisoxazoles. (1989)

Abstract The 1‐chloro‐1‐(trifluoromethyl)alkenes (II), prepared by three alternative pathways outlined in the reaction scheme, are dehydrochlorinated to give the trifluoromethylated acetylenes (V).
Supplemental Table 5 from Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics (2023)

&lt;p&gt;Supplemental Table 5&lt;/p&gt;
Higher-order resonant behavior in asymmetric nonlinear stochastic systems (1997)

We study periodically modulated bistable dynamic elements subject to Gaussian noise and a symmetry-breaking dc signal. The skewing of the bistable potential function by the dc signal leads to the appearance of even multiples of the drive frequency in the output power spectral density. The spectral amplitudes of all the harmonics are found to exhibit maxima as functions of the noise statistics and the dc signal; the maxima can be shown to depend on matchings of characteristic deterministic and stochastic time scales. A phenomenological description based on a generic bistable system is followed by actual perturbation calculations of the first two spectral amplitudes for a real system, a Josephson junction shorted by a superconducting loop (the mainstay of the rf superconducting quantum interference device). This behavior underlies a recently proposed ``frequency-shifting'' technique for circumventing detector noise limitations which would otherwise constrain the detection of very low-amplitude signals.
Channel Training for Analog FDD Repeaters: Optimal Estimators and Cramér–Rao Bounds (2017)

For frequency division duplex channels, a simple pilot loop-back procedure has been proposed that allows the estimation of the uplink (UL) and downlink (DL) channel subspaces between an antenna array and a fully analog repeater. For this scheme, we derive the maximum likelihood (ML) estimators for the UL and DL subspaces, formulate the corresponding Cramér-Rao bounds, and show the asymptotic efficiency of both (singular value decomposition (SVD) based) estimators by means of Monte Carlo simulations. In addition, we illustrate how to compute the underlying (rank-1) SVD with quadratic time complexity by employing the power iteration method. To enable power control for the data transmission, knowledge of the channel gains is needed. Assuming that the UL and DL channels have on average the same gain, we formulate the ML estimator for the uplink channel vector norm, and illustrate its robustness against strong noise perturbations by means of simulations.
Electronic transitions of SWCNTs in comparison to GO on Mn3O4/TiO2nanocomposites for hydrogen energy generation and solar photocatalysis (2021)

The conductivity of metal/metal oxide-doped TiO<sub>2</sub>nanomaterials is enhanced by the incorporation of carbonaceous materials,<italic>e.g.</italic>single-walled carbon nanotubes (SWCNTs) and graphene oxide (GO).
Oxidative Degradation of Aqueous Amine Solutions of MEA, AMP, MDEA, Pz: A Review (2013)

Alkanolamine based post-combustion capture processes (PCC) are currently the most attractive tech- nologies for CO2 capture. Solvents are degraded in this service by flue gas components, for example oxygen. Solvent degradation can be classified into two reaction types: 1) amine oxidative degradation through a) autoxidation pathways, b) oxidation in the presence of metal ions and 2) thermal degradation including reactions in the presence of CO2. This study represents a literature survey of oxidative degradation (reaction type 1a) of 2-Amino-1-ethanol (MEA), 2-Amino-2-methyl-1-propanol (AMP), N,N-Bis(2-hydroxyethyl)methyl-amine (MDEA), and Piperazine (Pz). Thermal degradation products (reaction type 2) are included where appropriate in order to contribute to a more complete degradation overview of these compounds.
Implementation of erythroid lineage analysis by flow cytometry in diagnostic models for myelodysplastic syndromes (2016)

Flow cytometric analysis is a recommended tool in the diagnosis of myelodysplastic syndromes. Current flow cytometric approaches evaluate the (im)mature myelo-/monocytic lineage with a median sensitivity and specificity of ~71% and ~93%, respectively. We hypothesized that the addition of erythroid lineage analysis could increase the sensitivity of flow cytometry. Hereto, we validated the analysis of erythroid lineage parameters recommended by the International/European LeukemiaNet Working Group for Flow Cytometry in Myelodysplastic Syndromes, and incorporated this evaluation in currently applied flow cytometric models. One hundred and sixty-seven bone marrow aspirates were analyzed; 106 patients with myelodysplastic syndromes, and 61 cytopenic controls. There was a strong correlation between presence of erythroid aberrancies assessed by flow cytometry and the diagnosis of myelodysplastic syndromes when validating the previously described erythroid evaluation. Furthermore, addition of erythroid aberrancies to two different flow cytometric models led to an increased sensitivity in detecting myelodysplastic syndromes: from 74% to 86% for the addition to the diagnostic score designed by Ogata and colleagues, and from 69% to 80% for the addition to the integrated flow cytometric score for myelodysplastic syndromes, designed by our group. In both models the specificity was unaffected. The high sensitivity and specificity of flow cytometry in the detection of myelodysplastic syndromes illustrates the important value of flow cytometry in a standardized diagnostic approach. The trial is registered at www.trialregister.nl as NTR1825; EudraCT n.: 2008-002195-10.
Identification of Non-HIV Immunogens That Bind to Germline b12 Predecessors and Prime for Elicitation of Cross-clade Neutralizing HIV-1 Antibodies (2015)

A fundamental challenge for developing an effective and safe HIV-1 vaccine is to identify vaccine immunogens that can initiate and maintain immune responses leading to elicitation of broadly neutralizing HIV-1 antibodies (bnAbs) through complex maturation pathways. We have previously found that HIV-1 envelope glycoproteins (Env) lack measurable binding to putative germline predecessors of known bnAbs and proposed to search for non-HIV immunogens that could initiate their somatic maturation. Using bnAb b12 as a model bnAb and yeast display technology, we isolated five (poly)peptides from plant leaves, insects, E. coli strains, and sea water microbes that bind to b12 putative germline and intermediate antibodies. Rabbit immunization with the (poly)peptides alone induced high titers of cross-reactive antibodies that neutralized HIV-1 isolates SF162 and JRFL. Priming rabbits with the (poly)peptides followed by boosts with trimeric gp140SF162 and then resurfaced Env (RSC3) induced antibodies that competed with mature b12 and neutralized tier 1 and 2 viruses from clade B, C and E, while control rabbits without (poly)peptide priming induced antibodies that did not compete with mature b12 and neutralized fewer isolates. The degree of competition with mature b12 for binding to gp140SF162 correlated with the neutralizing activity of the rabbit IgG. Reversing the order of the two boosting immunogens significantly affected the binding profile and neutralization potency of the rabbit IgG. Our study is the first to provide evidence that appears to support the concept that non-HIV immunogens may initiate immune responses leading to elicitation of cross-clade neutralizing antibodies.
Ultra Low Frequency Electric Field Probes for Gradient Coils Field Measurement During Medical Device Testing (2019)

In this work ultra-low frequency probes for measuring time-varying electric field produced in gradient coils were designed, fabricated and tested. A 2 cm short dipole antenna followed by an instrumentation amplifier was chosen to measure the electric field. The designed amplifier has a gain of 100 and a cutoff frequency of 31 KHz. Probes were fabricated on a 4-layers Printed Circuit Board (PCB), FR4 of thickness 1.57 mm and a copper thickness of 35 μm. Verification and validation of the probes were performed using a parallel plate capacitor with a known field which was calculated analytically and numerically. These calculations were compared against measurement results.
Pattern formation in activator-inhibitor systems (2022)

We study a two-component reaction-diffusion system of activator-inhibitor type with global inhibition that has been developed to understand qualitatively self-organized pattern formation in electrical two-layer systems. It is shown numerically that the global inhibition can change the expected bifurcation behaviour essentially; in particular, in a two-dimensional medium solitary structures may arise instead of hexagonal patterns and target patterns may arise instead of homogeneous oscillations. Additional solutions of the reaction-diffusion system are presented and compared with experimental results obtained from a semiconductor and a gas discharge system.
Scintillation from extended incoherent sources (1987)

The Green's function formalism is used to derive a series solution for the correlation of the intensity fluctuations of waves propagating through a random phase screen or an extended random medium from a spatially extended, incoherent source. The satistics of the random medium are assumed to be homogeneous in the direction transverse to the propagation direction. The spatial incoherence of the source produces two terms for the intensity correlation. One is the “standard” intensity correlation obtained by summing the intensity contributions from different regions of the source. The second describes the correlation of the rapid temporal fluctuations observed by Hanbury Brown and Twiss with their intensity interferometer. The introduction of a model narrowband receiver clarifies the role of these two contributions in a typical observation. The intensity spectrum of each contribution is expressed as a high and low spatial‐frequency series. When possible, these expressions are compared with previous results.
Nuclear repartitioning of galectin-1 by an extracellular glycan switch regulates mammary morphogenesis (2016)

Branching morphogenesis in the mammary gland is achieved by the migration of epithelial cells through a microenvironment consisting of stromal cells and extracellular matrix (ECM). Here we show that galectin-1 (Gal-1), an endogenous lectin that recognizes glycans bearing N-acetyllactosamine (LacNAc) epitopes, induces branching migration of mammary epithelia in vivo, ex vivo, and in 3D organotypic cultures. Surprisingly, Gal-1's effects on mammary patterning were independent of its glycan-binding ability and instead required localization within the nuclei of mammary epithelia. Nuclear translocation of Gal-1, in turn, was regulated by discrete cell-surface glycans restricted to the front of the mammary end buds. Specifically, α2,6-sialylation of terminal LacNAc residues in the end buds masked Gal-1 ligands, thereby liberating the protein for nuclear translocation. Within mammary epithelia, Gal-1 localized within nuclear Gemini bodies and drove epithelial invasiveness. Conversely, unsialylated LacNAc glycans, enriched in the epithelial ducts, sequestered Gal-1 in the extracellular environment, ultimately attenuating invasive potential. We also found that malignant breast cells possess higher levels of nuclear Gal-1 and α2,6-SA and lower levels of LacNAc than nonmalignant cells in culture and in vivo and that nuclear localization of Gal-1 promotes a transformed phenotype. Our findings suggest that differential glycosylation at the level of tissue microanatomy regulates the nuclear function of Gal-1 in the context of mammary gland morphogenesis and in cancer progression.
Impact of within-die parameter fluctuations on future maximum clock frequency distributions (2002)

The impact of parameter fluctuations on future circuit performance is evaluated by employing rigorously derived device and circuit models to calculate the critical path delay distributions resulting from die-to-die and within-die fluctuations. Utilizing these distributions with a recently derived FMAX distribution model validated by measured data, the effect of within-die fluctuations on the FMAX mean is forecast for the 180, 130, 100, 70 and 50 nm technology generations. Systematic within-die fluctuations impose the largest performance degradation resulting from parameter fluctuations. Assuming a 3/spl sigma/ channel length deviation of 20%, projections for the 50 nm technology generation indicate that essentially a generation of performance gain can be lost due to systematic within-die fluctuations. This analysis should encourage efforts toward tightening within-die process controls and developing circuit design methodologies that suppress the impact of within-die parameter fluctuations on circuit performance.