gebhart/patrepeval huggingface dataset:
Integrated Restoration for Next-Generation IP-Over-Optical Networks (2011)

This paper describes work performed for the Defense Advanced Research Projects Agency CORONET-funded Protocols and Architectures for Resilient Agile Global Optical Networks project to build an integrated IP/optical layer (OL) restoration architecture that combines transponder-shared mesh restoration at the OL with innovative methods of using router line cards and OL reconfigurability to restore from a layer 3 outage. This is a significant advancement over current restoration strategies, which typically add significant additional layer 3 capacity (i.e., additional IP links) to allow all failures to be restored at layer 3 alone. The network and restoration architectures in the integrated restoration method are described, as are design methodologies for each layer. A realistic cost model is applied to demonstrate that the proposed integrated IP/OL restoration strategy may have significant cost advantages for a core IP network when compared to the commonly used restoration strategies today.
Automated N-Glycopeptide Identification Using a Combination of Single- and Tandem-MS (2007)

We describe Peptoonist, a program that can automatically identify the glycans (sugars) present at each N-glycosylation site of a protein. The input to Peptoonist is a series of mass spectra, both MS and MS/MS, obtained from a liquid chromatography (LC) run of proteolytically digested purified glycoproteins. The program uses MS/MS to identify glycosylated peptides and single-MS to identify the N-glycans present on each of these peptides, at least to the level of monosaccharide composition. We validate the program on an LC run of mouse zona pellucida proteins that had been intensively hand annotated by a human expert. Our program doubled the number of glycopeptide identifications, and also found several possible errors in the hand annotation. In addition, it automatically made most of the same glycan isomer identifications as the expert annotator.
Print quality analysis for ink-saving algorithms (2011)

Ink-saving strategies for CMYK printers have evolved from their earlier stages where the 'draft' print mode was the main option available to control ink usage. The savings were achieved by printing alternate dots in an image at the expense of reducing print quality considerably. Nowadays, customers are not only unwilling to compromise quality but have higher expectations regarding both visual print quality and ink reduction solutions. Therefore, the need for more intricate ink-saving solutions with lower impact on print quality is evident. Printing-related factors such as the way the printer places the dots on the paper and the ink-substrate interaction play important and complex roles in the characterization and modeling of the printing process that make the ink reduction topic a challenging problem. In our study, we are interested in benchmarking ink-saving algorithms to find the connections between different ink reduction levels of a given ink-saving method and a set of print quality attributes. This study is mostly related to CMYK printers that use dispersed dot halftoning algorithms. The results of our efforts to develop such an evaluation scheme are presented in this paper.
Mr perfusion studies with t1‐weighted echo planar imaging (1995)

The T1 perfusion model has worked well in brain functional studies where flow changes are measured. Using selective and nonselective inversion pulses, a new method has been developed to study steady-state brain blood flow. The authors obtained flow-sensitive images using selective inversion and flow-insensitive images using nonselective inversion. Subtraction of flow-insensitive images from flow-sensitive images gave us flow-weighted images with good gray-white flow contrast in cortical gray matter as well as in the thalamus and basal ganglia. Fitting T1s of flow-insensitive and flow-sensitive images allowed us to obtain preliminary results of brain blood flow maps. Two specific problems can seriously affect the accuracy of the brain blood flow values and the gray-white flow contrast of brain blood flow maps. These are the problems of the partial volume effect of CSF and gray matter, and the difference between blood T1 and white matter T1. The authors discuss in detail the character of these problems and present a number of approaches to manage such problems.
Integrated sample preparation and sensing: Microresonator optical sensors embedded in digital electrowetting microfluidics systems (2011)

The intimate integration of digital electrowetting microfluidics and optical microcavity sensors results in an excellent platform for low power consumption, high sensitivity integrated sample preparation and testing, which is particularly useful for medical diagnostics and water quality testing. In this work, a microresonator structure with a buried channel waveguide (resulting in an external Q factor of 28,000 in silicone oil and 17,000 in water) was embedded in the top plate of a digital electrowetting system, enabling sensing with a single droplet of <;100 nL volume. The integrated system was used to successfully demonstrate resonant optical wavelength shifts proportional to index of refraction changes of the liquid actuated to the sensor.
Peripheral Artery Disease and Glaucoma (2009)

Peripheral artery disease was related to glaucoma, supporting an association between large-vessel atherosclerotic disease and glaucoma. However, because the study sample included a high proportion of persons with diabetes, further research is needed to determine the relevance of these results to the general population.
Electrothermally Actuated Microbeams With Varying Stiffness (2017)

We present axially loaded clamped-guided microbeams that can be used as resonators and actuators of variable stiffness, actuation, and anchor conditions. The applied axial load is implemented by U-shaped electrothermal actuators stacked at one of the beams edges. These can be configured and wired in various ways, which serve as mechanical stiffness elements that control the operating resonance frequency of the structures and their static displacement. The experimental results have shown considerable increase in the resonance frequency and mid-point deflection of the microbeam upon changing the end conditions of the beam. These results can be promising for applications requiring large deflection and high frequency tunability, such as filters, memory devices, and switches. The experimental results are compared to multi-physics finite-element simulations showing good agreement among them.
Phosphinidenetantalum(V) Complexes of the Type [(N3N)TaPR] as Phospha‐Wittig Reagents (1993)

A smooth reaction with aldehydes yielding phosphaalkenes and the oxotantalum complex [(N3N)TaO] is reported for the phosphinidine complexes mentioned in the title, which have a nucleophilic phosphorus atom. The crystal structure of [(N3N)-TaPR] (1, R  cyclohexyl) shows that the reactive TaPR unit is stabilized by its location within a pocket afforded by the SiMe, substituents of the (N3N) ligand.
Performance of WLAN RSS-based SON for LTE/WLAN access network selection (2014)

Mobile Network Operators (MNOs) are integrating carrier-grade Wireless Local Area Network (WLAN) to cellular networks to improve network performance and user experience. Access network selection (ANS) between cellular and WLAN plays a key role in the integration. Given the complexity of heterogeneous networks characterized by multiple network layer deployments and inhomogeneous traffic distribution, the ANS has to automatically adapt to dynamic network conditions. In this article, we present and evaluate a Self-Organizing Network (SON) algorithm for tuning the ANS between the Long Term Evolution (LTE) and WLAN systems. The proposed SON algorithm adopts a WLAN received signal strength (RSS) threshold to control the access selection. The RSS threshold is updated by the SON algorithm based on periodically monitored load in the LTE and WLAN systems. The SON algorithm is evaluated by simulations in realistic heterogeneous network scenarios and proved effective in improving user experience.
The Left Null Space of S (2006)

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Induction of Membrane Chloride Currents in Xenopus Laevis Oocytes By of Sulfonyl Amide Sweeteners Acesulfame K and Saccharin (2000)

Sweet receptors have remained elusive. In Xenopus oocytes sulfonyl amide sweeteners but not sweet compounds belonging to other chemical classes dose dependently induced membrane chloride currents via the inositol trisphosphate/calcium pathway. Induction of membrane currents was exclusively observed following extracellular application of sulfonyl amides but not by intracellular pressure injection, suggesting the involvement of a plasma membrane receptor. The presence of this receptor in oocytes and the observed seasonal variation of the sweet response offers an opportunity for a molecular cloning approach.
Hybrid Scheduling/Signal-Level Coordination in the Downlink of Multi-Cloud Radio-Access Networks (2014)

In the context of resource allocation in cloud- radio access networks, recent studies assume either signal-level or scheduling-level coordination. This paper, instead, considers a hybrid level of coordination for the scheduling problem in the downlink of a multi-cloud radio- access network, so as to benefit from both scheduling policies. Consider a multi-cloud radio access network, where each cloud is connected to several base-stations (BSs) via high capacity links, and therefore allows joint signal processing between them. Across the multiple clouds, however, only scheduling-level coordination is permitted, as it requires a lower level of backhaul communication. The frame structure of every BS is composed of various time/frequency blocks, called power- zones (PZs), and kept at fixed power level. The paper addresses the problem of maximizing a network-wide utility by associating users to clouds and scheduling them to the PZs, under the practical constraints that each user is scheduled, at most, to a single cloud, but possibly to many BSs within the cloud, and can be served by one or more distinct PZs within the BSs' frame. The paper solves the problem using graph theory techniques by constructing the conflict graph. The scheduling problem is, then, shown to be equivalent to a maximum- weight independent set problem in the constructed graph, in which each vertex symbolizes an association of cloud, user, BS and PZ, with a weight representing the utility of that association. Simulation results suggest that the proposed hybrid scheduling strategy provides appreciable gain as compared to the scheduling-level coordinated networks, with a negligible degradation to signal-level coordination.
P‐171: Modulation of Dibenzothiophene and Carbazole Moieties in Host Material towards High Performance Blue Phosphorescent OLEDs (2018)

A new host material was synthesized for blue phosphorescent organic light emitting diodes (PHOLEDs) by modulating carbazolyl‐carbazole and dibenzothiophene groups. In particular, by comparing the characteristics of the two hosts with and without a biphenyl linker, we studied the effects of the biphenyl linker on photophysical properties and on the device performances of a blue emitting phosphorescent dopant. As a result, the newly synthesized host materials were functioned as high efficiency and long lifetime host materials in blue phosphorescent devices and they prolonged life span of the blue devices by 5 times compared to a common mCBP blue host.
Analysis of combustion chamber deposit growth on temperature swing thermal barrier coatings in a spark ignition engine (2022)

Temperature swing thermal barrier coatings (TBCs) have the potential to improve efficiency and performance through thermal management of the combustion chamber. However, the effects of combustion chamber deposits (CCDs) on the surface of the TBCs are unclear. Therefore, this paper analyzes the impact of CCD formation on a temperature swing TBC. A piston and a heat flux probe coated with a novel material are installed in a single-cylinder research engine at a low-load condition for 62.5 h to promote CCD growth. Every 12.5 h, the performance at a knock limited condition is assessed and thermophysical property measurements on the heat flux probe are performed. Net thermal efficiency increased by 0.4% absolute after 12.5 h relative to the baseline condition, but further CCD growth caused a dithering of efficiency between the 12.5 h and baseline points. The KLSA retarded consistently throughout this period. External property measurements with the coated heat flux probe showed an improvement in the thermophysical properties of the TBC/CCD layer.
Changes in actin organization during the cytotoxic process (1994)

Changes in organization of F-actin during the cytotoxic process between NK and K562 cells have been observed and studied using confocal laser scanning microscopy and quantitative fluorescence microscopy. An increase in F-actin content and orientation of F-actin towards the target cell have been observed in conjugated NK cells. The increase in F-actin content probably reflects activation of the NK cell for the killing process. An increase in F-actin content in the conjugated K562 cell, occurring simultaneously with the appearance of filamentous actin structures that often originated/ended at the contact place with the NK cell, was also observed. These changes were delayed compared to the increase in F-actin content in the NK cell and were accompanied by increasing cytotoxic activity. This indicates that they were results of the interaction of the K562 cell with the activated NK cell. The possible role of target cell microfilaments in the cytotoxic process is addressed.
An Efficient Synthesis of Carlosic Acid and Other 5‐Carboxymethyltetronates from Malates. (2006)

Abstract For Abstract see ChemInform Abstract in Full Text.
Relation between Calcium Oxalate Hydrate Form Found in Renal Calculi and Some Urinary Parameters (1990)

In calcium oxalate urolithiasis, the monohydrate and dihydrate forms can be found. The aim of this paper is to examine a group of patients with calcium oxalate calculi to determine the calcium oxalate form and the possible relationship with calcium and other urinary biochemical parameters. It was found that calcium oxalate monohydrate is more frequent in the normocalciuric group and also is associated with a lack of inhibitory capacity, while a mixed calculus of calcium oxalate and phosphate or calcium oxalate dihydrate can be related with hypercalciuria.
Supplementary Figure 1 from Genetic and Pharmacologic Evidence That mTOR Targeting Outweighs mTORC1 Inhibition as an Antimyeloma Strategy (2023)

&lt;p&gt;PDF file - 64K, Supplementary Figure 1. Detection of phospho-proteins in myeloma patient cells.&lt;/p&gt;
Harmonization of Multiple SARS-CoV-2 Reference Materials Using the WHO IS (NIBSC 20/136): Results and Implications (2022)

Despite some concordance between laboratories, qualification of secondary materials to the WHO IS using arbitrary international units or binding antibody units per milliliter (BAU/ml) does not provide any benefit to the reference materials overall, due to the lack of consistent agreeable international unit (IU) or BAU/ml conversions between laboratories. Secondary standards should be qualified to well-characterized reference materials, such as the WHO IS, using serology assays that are similar to the ones used for the original characterization of the WHO IS.
Assessing Low‐frequency Repetitive Transcranial Magnetic Stimulation with Functional Magnetic Resonance Imaging: A Case Series (2011)

These findings benefit rTMS rehabilitation studies by examining haemodynamics on repeated days of stimulation and incorporating resting-state brain connectivity analysis to further understand underlying neural mechanisms. Furthermore, this work encourages the utilization of resting connectivity in future rTMS studies.
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c (2004)

We explored the effects of bile acids on triglyceride (TG) homeostasis using a combination of molecular, cellular, and animal models. Cholic acid (CA) prevents hepatic TG accumulation, VLDL secretion, and elevated serum TG in mouse models of hypertriglyceridemia. At the molecular level, CA decreases hepatic expression of SREBP-1c and its lipogenic target genes. Through the use of mouse mutants for the short heterodimer partner (SHP) and liver X receptor (LXR) α and β, we demonstrate the critical dependence of the reduction of SREBP-1c expression by either natural or synthetic farnesoid X receptor (FXR) agonists on both SHP and LXRα and LXRβ. These results suggest that strategies aimed at increasing FXR activity and the repressive effects of SHP should be explored to correct hypertriglyceridemia.
ChemInform Abstract: Preparation of S‐(‐)‐2‐Acetoxymethyl‐2,5‐dihydrofuran and S‐(‐)‐N‐Boc‐2‐hydroxymethyl‐2,5‐dihydropyrrole by Enzymatic Resolution. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Surfacing on Aluminum Alloy. Report 2. Gas Tungsten Arc Welding Process for Surfacing Aluminum Alloys with Al-Cu Cored Wire. (1993)

The authors have investigated on surfacing technique on aluminum alloys by using gas tungsten arc welding (GTAW) process.
Possible mechanisms of the cancer‐preventive activities of green tea (2006)

The cancer-preventive activities of tea and some tea constituents, such as caffeine and (-)-epigallocatechin-3-gallate (EGCG), have been demonstrated in animal models. The mechanisms of action of the tea constituents have been extensively investigated, but the mechanisms for the cancer-preventive activity of tea are not clearly understood. This chapter discusses some of the reported studies on the green tea polyphenol, EGCG, and the major issues in the interpretation of these data. Among the different activities of EGCG observed in cell culture systems, we need to select the physiologically relevant ones based on the biological importance of the target as well as the effective concentration and whether the reaction can take place in vivo because of the limited bioavailability of EGCG. We also need to distinguish between primary and subsequent events. Possible artifacts should be recognized. The cancer-preventive mechanisms need to be validated in animal models or human samples.
O -GlcNAcylation, oxidation and CaMKII contribute to atrial fibrillation in type 1 and type 2 diabetes by distinct mechanisms (2020)

Abstract Diabetes mellitus and atrial fibrillation (AF) are major unsolved public health problems, and diabetes is an independent risk factor for AF in patients. However, the mechanism(s) underlying this clinical association is unknown. Elevated protein O -GlcNAcylation (OGN) and reactive oxygen species (ROS) are increased in diabetic hearts, and calmodulin kinase II (CaMKII) is a proarrhythmic signal that may be activated by OGN (OGN-CaMKII) and ROS (ox-CaMKII). We induced type 1 (T1D) and type 2 diabetes (T2D) in a portfolio of genetic mouse models capable of dissecting the role of OGN and ROS at CaMKII and the type 2 ryanodine receptor (RyR2), an intracellular Ca 2+ channel implicated as an important downstream mechanism of CaMKII- mediated arrhythmias. Here we show that T1D and T2D significantly increased AF, similar to observations in patients, and this increase required CaMKII. While T1D and T2D both require ox-CaMKII to increase AF, they respond differently to loss of OGN-CaMKII or OGN inhibition. Collectively, our data affirm CaMKII as a critical proarrhythmic signal in diabetic AF, and suggest ROS primarily promotes AF by ox-CaMKII, while OGN promotes AF by diverse mechanisms and targets, including CaMKII and RyR2. The proarrhythmic consequences of OGN- and ox-CaMKII differ between T1D and T2D. These results provide new and unanticipated insights into the mechanisms for increased AF in diabetes mellitus, and suggest successful future therapies will need to be different for AF in T1D and T2D.
Tissue Microarrays to Visualize Influenza D Attachment to Host Receptors in the Respiratory Tract of Farm Animals (2021)

The trimeric hemagglutinin-esterase fusion protein (HEF) of influenza D virus (IDV) binds 9-O-acetylated sialic acid receptors, which are expressed in various host species. While cattle are the main reservoir for IDV, the viral genome has also been detected in domestic pigs. In addition, antibodies against IDV have been detected in other farm animals such as sheep, goats, and horses, and even in farmers working with IDV positive animals. Viruses belonging to various IDV clades circulate, but little is known about their differences in host and tissue tropism. Here we used recombinantly produced HEF proteins (HEF S57A) from the major clades D/Oklahoma (D/OK) and D/Oklahoma/660 (D/660) to study their host and tissue tropism and receptor interactions. To this end, we developed tissue microarrays (TMA) composed of respiratory tissues from various farm animals including cattle, domestic pigs, sheep, goats, and horses. Protein histochemical staining of farm animal respiratory tissue-microarrays with HEF proteins showed that cattle have receptors present over the entire respiratory tract while receptors are only present in the nasal and pharyngeal epithelium of pigs, sheep, goats, and horses. No differences in tropism for tissues and animals were observed between clades, while hemagglutination assays showed that D/OK has a 2-fold higher binding affinity than D/660 for receptors on red blood cells. The removal of O-acetylation from receptors via saponification treatment confirmed that receptor-binding of both clades was dependent on O-acetylated sialic acids.
Macrophage depletion blocks congenital SARM1-dependent neuropathy (2022)

Axon loss contributes to many common neurodegenerative disorders. In healthy axons, the axon survival factor NMNAT2 inhibits SARM1, the central executioner of programmed axon degeneration. We identified 2 rare NMNAT2 missense variants in 2 brothers afflicted with a progressive neuropathy syndrome. The polymorphisms resulted in amino acid substitutions V98M and R232Q, which reduced NMNAT2 NAD+-synthetase activity. We generated a mouse model to mirror the human syndrome and found that Nmnat2V98M/R232Q compound-heterozygous CRISPR mice survived to adulthood but developed progressive motor dysfunction, peripheral axon loss, and macrophage infiltration. These disease phenotypes were all SARM1-dependent. Remarkably, macrophage depletion therapy blocked and reversed neuropathic phenotypes in Nmnat2V98M/R232Q mice, identifying a SARM1-dependent neuroimmune mechanism as a key driver of disease pathogenesis. These findings demonstrate that SARM1 induced inflammatory neuropathy and highlight the potential of immune therapy as a treatment for this rare syndrome and other neurodegenerative conditions associated with NMNAT2 loss and SARM1 activation.
Demonstration of a high speed 4-channel integrated silicon photonics WDM link with hybrid silicon lasers (2010)

This article consists of a collection of slides from the author's conference presentation on the demonstration of a high speed, 4-channel integrated silicon photonics WDM link wiht hybrid silicon lasers. Some of the specific topics discussed include: presents an overview of these technologies and reports on the platforms they support; testing results; and WDM silicon photonics links and link testing results.