gebhart/patrepeval huggingface dataset:
Spectral Comparison of Real Spectra with Site Effects Included vs MOC-2008 Teorical Spectra for Guadalajara City, Mexico (2013)

Guadalajara city is the capital of the Mexican federal state of Jalisco. It is located close to the Pacific coast and is subjected to a large seismic risk. We present a seismic response study for some sites along the city. We calculated response spectra of shear-waves by using seismic records of actual earthquakes registered on rock and near the source as Green functions and propagated them trough a flat and horizontal layered media using a linear equivalent method to compare them with the response spectra calculated according to the Federal Commission of Electricity (CFE) seismic design buildings Manual (MOC-2008, 2008) which is widely used as reference on construction projects in Mexico. Our results show that MOC-2008 manual underestimates the spectral amplitudes and frequency band for the response spectra.
Low thermal budget antimony/phosphorus NMOS technology for CMOS (2002)

A novel antimony-preamorphized phosphorus process (Sb/P) for NMOS source/drain formation is presented. It is demonstrated that very shallow (<or=0.15 mu m) phosphorus junctions with ideal diode characteristics and very low leakage current can be realized by using Sb pre-amorphization and RTA. The authors also fabricated 0.25 mu m effective channel length NMOS transistors with these shallow Sb/P diffusions and 7 nm gate oxide and obtained excellent device characteristics, e.g., Gm/sub (sat)/=236 mS/mm, S=79 mV/dec, and total source/drain series resistance of 420 Omega - mu m. These devices have short-channel effects, punch-through voltage, and channel hot carrier reliability comparable to those with conventional (furnace drive-in) arsenic diffusions. The more graded lateral profile of these Sb/P junctions also reduces the gate induced drain leakage by 10X compared with As devices. This low thermal-budget Sb/P process is therefore scalable and extendible to deep submicron bulk and 3-D CMOS ULSI.<<ETX>>
Biochemical and Structural Characterization of Benzenoid Carboxyl Methyltransferases Involved in Floral Scent Production in Stephanotis floribunda and Nicotiana suaveolens (2004)

Flower-specific benzenoid carboxyl methyltransferases from Stephanotis floribunda and Nicotiana suaveolens were biochemically and structurally characterized. The floral scents of both these species contain higher levels of methyl benzoate and lower levels of methyl salicylate. The S. floribunda enzyme has a 12-fold lower K(m) value for salicylic acid (SA) than for benzoic acid (BA), and results of in silico modeling of the active site of the S. floribunda enzyme, based on the crystal structure of Clarkia breweri salicylic acid methyltransferase (SAMT), are consistent with this functional observation. The enzyme was therefore designated SAMT. The internal concentration of BA in S. floribunda flowers is three orders of magnitude higher than the SA concentration, providing a rationale for the observation that these flowers synthesize and emit more methyl benzoate than methyl salicylate. The N. suaveolens enzyme has similar K(m) values for BA and SA, and the in silico modeling results are again consistent with this in vitro observation. This enzyme was therefore designated BSMT. However, the internal concentration of BA in N. suaveolens petals was also three orders of magnitude higher than the concentration of SA. Both S. floribunda SAMT and N. suaveolens BSMT are able to methylate a range of other benzenoid-related compounds and, in the case of S. floribunda SAMT, also several cinnamic acid derivatives, an observation that is consistent with the larger active site cavity of each of these two enzymes compared to the SAMT from C. breweri, as shown by the models. Broad substrate specificity may indicate recent evolution or an adaptation to changing substrate availability.
Structure, Oligomerisation and Interactions of β-Lactoglobulin (2016)

β-Lactoglobulin (βLg), as the most abundant whey protein in ruminant milk and as a useful model protein, is the subject of countless biophysical studies in the literature, yet its physiological role is hitherto unknown. This chapter deals with studies that focus on the structure of βLg, its oligomeric behaviour and the interactions that this protein participates in. These and further studies are necessary to understand how the protein’s physicochemical properties may influence the processing, digestion and immunogenicity of ruminant milks and their products. However, there is also a need for research into the interactions that occur naturally between βLg and other components in milk, as this may give us insight into the physiological role of the protein.
Novel double layer graphene transistors-bilayer pseudospin FETs and 2D-2D tunnel FETs (2012)

The semiconductor industry is placing increasing emphasis on emerging materials and devices that may provide solutions to end-of-the-CMOS-roadmap problems beyond 2020 [Table 1]. The remarkable electronic properties of graphene can lead to novel beyond-CMOS logic device concepts, such as the Bilayer pseudoSpin FET (BiSFET), which can potentially be an ultra-low power replacement for the MOSFET [1]. The BiSFET is based on many-body tunneling of an excitonic Bose condensate in double layer graphene [2]. One can also have single particle 2D-to-2D tunneling FETs based on the BiSFET architecture, with similar current-voltage behavior demonstrating negative differential resistance.
Effects of frequency-dependent membrane capacitance on neural excitability (2015)

This is the first comprehensive analysis of the effects of dispersive capacitance on neural excitability, and as the interest on stimulation with kHz signals gains more attention, it defines the regions over which frequency-dependent membrane capacitance, c(f), should be considered.
Nanostructured Carbons Prepared by Ultrasonic Spray Pyrolysis (2010)

Porous carbon powders were prepared by ultrasonic spray pyrolysis of solutions of sucrose and sodium carbonate or bicarbonate. The decomposition of the carbonate salt evolves gases that create porosity in the carbon material without sacrificial templating agents. Microporous particles with a macroporous or hollow interior have been produced.
Ordering of Functional Groups by Confining Grafted Chains, Star Polymers, or Polymer-Stabilized Nanoparticles (2020)

Understanding and controlling the self-organization of functionalized sites are crucial in biological systems, in catalysis, and to target drug delivery. Here we investigate the possibility of spatiotemporal self-organization offered by the development of sequence-controlled polymers. As a key factor in reducing the configurational entropy of a chain, confinement can enhance or hinder the ordering of chain segments. Using molecular dynamics simulations and scaling concepts, we show that the segments of a closely grafted chains inside a patch are radially localized under planar confinement. We investigate the statistical properties of this self-organization and show that it results from an interplay between confinement and excluded volume between monomers. Increasing the length of polymers as well as the number of chains inside the patch enhances the localization and spatial sequencing order of the segments.
Reasoning over Secure Business Processes (2013)

Modern enterprise systems are often process-based, i.e., they allow for the direct execution of business processes that are specified in a high-level language such as BPMN.We present an approach for validating the compliance of the business processes during design-time. Basically, while modeling a business process the business analyst specifies as well the security and compliance requirements the business process should comply to. By pressing a button, these requirements are validated and the results are presented in a graphical format to the business analysis. As proof-of-concept we created a prototype in which the SVaaS Server is deployed on the SAP NetWeaver Cloud and two SVaaS Connectors are built to enable two well-known BPMN tools, SAP NetWeaver BPM and Activiti, to consume SVaaS against industrial relevant business processes.
The Telomerization of 1,3‐Dienes – A Reaction Grows Up (2019)

Abstract The front cover artwork for Issue 04/2019 is provided by researchers from the group for Molecular Catalysis at the Max‐Planck‐Institute for Chemical Energy Conversion (Germany). The image shows an assembly line that symbolizes the versatility and potential selectivity of the telomerization reaction. See the Minireview itself at https://doi.org/10.1002/cctc.201801821 .
Cylindrical Transducer for Intravascular ARFI Imaging: Design and Feasibility (2019)

Intravascular acoustic radiation force impulse (IV-ARFI) imaging has the potential to identify vulnerable atherosclerotic plaques and improve clinical treatment decisions and outcomes for patients with coronary heart disease. Our long-term goal is to develop a thin, flexible catheter probe that does not require mechanical rotation to achieve high-resolution IV-ARFI imaging. In this work, we propose a novel cylindrical transducer array design for IV-ARFI imaging and investigate the feasibility of this approach. We present the construction of a 2.2-mm-long, 4.6-Fr cylindrical prototype transducer to demonstrate generating large ARFI displacements from a small toroidal beam, and we also present simulations of the proposed IV-ARFI cylindrical array design using Field II and a cylindrical finite-element model of vascular tissues and soft plaques. The prototype transducer was found to generate peak radial displacements of over [Formula: see text] in soft gelatin phantoms, and simulations demonstrate the ability of the array design to obtain ARFI images and distinguish soft plaque targets from surrounding, stiffer vessel wall tissue. These results suggest that high-resolution IV-ARFI imaging is possible using a cylindrical transducer array.
Electronic and Ionic Wirings Versus the Insertion Reaction Contributions to the Polarization in LiFePO[sub 4] Composite Electrodes (2010)

International audience
Abstract 16022: Failed Defibrillation Shocks Change Activation Patterns Following Prolonged but Not Short Duration Ventricular Fibrillation (2016)

Introduction: Recent studies have demonstrated that as ventricular fibrillation (VF) persists past the first 1-2 minutes, 3 distinct patterns of activity can be present subendocardially: chaotic, r...
SEXUAL-DIMORPHISM IN HUMAN IMMUNE SYSTEM AGING (2022)

Abstract Differences in immune function and responses contribute to health- and life-span disparities between sexes. However, the role of sex in immune system aging is not well understood. Here, we characterize peripheral blood mononuclear cells from 172 healthy adults 22–93 years of age using ATAC-seq, RNA-seq and flow cytometry. These data reveal a shared epigenomic signature of aging including declining naïve T cells and increasing monocyte and cytotoxic cell functions. These changes are greater in magnitude in men and accompanied by a male-specific decline in B-cell-specific loci. Interestingly, genomic differences between sexes increase after age 65, with men having higher innate and pro-inflammatory activity and lower adaptive activity. In a separate cohort (n=39) we studied how older adults respond to two available pneumococcal vaccines: T-dependent Prevnar and T-independent Pneumovax. How older adults respond to these vaccines at the molecular and cellular level, and whether there are pre-vaccination predictors for vaccine responsiveness, is poorly understood. To address this, we characterized serum antibody responses and peripheral blood leukocyte composition using flow cytometry and transcriptional profiles using RNA-seq, in healthy older adults before and after vaccination. The vaccines induced comparable serological responses and increases in the number of ICOS+ T follicular helper cells. A shared plasmablast transcriptional signature (IGHG2, IGHA1, IGHA2) was induced by both vaccines ten days after vaccination, which is distinct from influenza vaccine responses. Importantly, the pre-vaccination (baseline) ratio of Th1/Th17 cells predicted responsiveness to Prevnar but not to Pneumovax. Interestingly, women had higher levels of Th1/Th17; and responded stronger to Prevnar compared to men. This study uncovered how older adults respond to different pneumococcal vaccines and demonstrated the significance of considering biological sex and the immune cell composition for precision vaccinology.
Expression of Ectolipid Phosphate Phosphohydrolases in 3T3F442A Preadipocytes and Adipocytes (2002)

Because of its production by adipocytes and its ability to increase preadipocyte proliferation, lysophosphatidic acid (LPA) could participate in the paracrine control of adipose tissue development. The aim of the present study was to determine which enzyme activities are involved in exogenous LPA hydrolysis by preadipocytes and adipocytes. Using a quantitative method, we observed that extracellular LPA rapidly disappeared from the culture medium of 3T3F442A preadipocytes. This disappearance was strongly slowed down in the presence of the phosphatase inhibitors, sodium vanadate and sodium pervanadate. By using [(33)P]LPA on intact 3T3F442A preadipocytes, we found that 90% of LPA hydrolysis resulted from LPA phosphatase activity biochemically related to previously described ectolipid phosphate phosphohydrolases (LPPs). Quantitative real time reverse transcriptase-PCR revealed that 3T3F442A preadipocytes expressed mRNAs of three known Lpp gene subtypes (1, 2, and 3), with a predominant expression of Lpp1 and Lpp3. Differentiation of 3T3F442A preadipocytes into adipocytes led to an 80% reduction in ecto-LPA phosphatase activity, with a concomitant down-regulation in Lpp1, Lpp2, and Lpp3 mRNA expression. Despite this regulation, treatment of 3T3F442A adipocytes with sodium vanadate increased LPA production in the culture medium, suggesting the involvement of ecto-LPA phosphatase activity in the control of extracellular production of LPA by adipocytes. In conclusion, these data demonstrate that hydrolysis of extracellular LPA by preadipocytes and adipocytes mainly results from a dephosphorylation activity. This activity (i) occurs at the extracellular face of cell membrane, (ii) exhibits biochemical characteristics similar to those of the LPP, (iii) is negatively regulated during adipocyte differentiation, and (iv) plays an important role in the control of extracellular LPA production by adipocytes. Ecto-LPA phosphatase activity represents a potential target to control adipose tissue development.
Real-time optical analysis of a colorimetric LAMP assay for SARS-CoV-2 in saliva with a handheld instrument improves accuracy compared to endpoint assessment (2021)

Abstract Controlling the course of the COVID-19 pandemic will require widespread deployment of consistent and accurate diagnostic testing of the novel coronavirus SARS-CoV-2. Ideally, tests should detect a minimum viral load, be minimally invasive, and provide a rapid and simple readout. Current FDA-approved RT-qPCR-based standard diagnostic approaches require invasive nasopharyngeal swabs and involve laboratory-based analyses that can delay results. Recently, a loop mediated isothermal nucleic acid amplification (LAMP) test that utilizes colorimetric readout received FDA approval. This approach utilizes a pH indicator dye to detect drop in pH from nucleotide hydrolysis during nucleic acid amplification. This method has only been approved for use with RNA extracted from clinical specimens collected via nasopharyngeal swabs. In this study, we developed a quantitative LAMP-based strategy to detect SARS-CoV-2 RNA in saliva. Our detection system distinguished positive from negative sample types using a handheld instrument that monitors optical changes throughout the LAMP reaction. We used this system in a streamlined LAMP testing protocol that could be completed in less than two hours to directly detect inactivated SARS-CoV-2 in minimally processed saliva that bypassed RNA extraction, with a limit of detection (LOD) of 50 genomes/reaction. The quantitative method correctly detected virus in 100% of contrived clinical samples spiked with inactivated SARS- CoV-2 at either 1X (50 genomes/reaction) or 2X (100 genomes/reaction) of the LOD. Importantly the quantitative method was based on dynamic optical changes during the reaction so was able to correctly classify samples that were misclassified by endpoint observation of color.
ChemInform Abstract: Towards Stereochemical and Conformational Assignment in Flexible Molecules Using NOEs and Molecular Modelling. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Ultra-Broadband, Infrared Astro-Comb Generation (2018)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text T. Steinmetz, Y. Wu, R. A. Probst, H. Hoogland, M. Halder, P. Adel, O. Mandel, S. Donath, J. Adelung, and R. Holzwarth, "Ultra-Broadband, Infrared Astro-Comb Generation," in Conference on Lasers and Electro-Optics, OSA Technical Digest (online) (Optica Publishing Group, 2018), paper STu3P.2. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Supplementary Table S1 from Avian Paramyxovirus 4 Antitumor Activity Leads to Complete Remissions and Long-term Protective Memory in Preclinical Melanoma and Colon Carcinoma Models (2023)

&lt;p&gt;APMV-4 reverse genetics system primers&lt;/p&gt;
Repurposing FDA-approved drugs to combat drug-resistant Acinetobacter baumannii (2010)

The paucity of identified compounds active against drug-resistant A. baumannii exemplifies its ability to resist antimicrobials as well as the resilience of drug-resistant Gram-negative pathogens. Repurposing of approved drugs is a viable alternative to de novo drug discovery and development.
A Scalable Space-efficient In-database Interpretability Framework for Embedding-based Semantic SQL Queries (2023)

AI-Powered database (AI-DB) is a novel relational database system that uses a self-supervised neural network, database embedding, to enable semantic SQL queries on relational tables. In this paper, we describe an architecture and implementation of in-database interpretability infrastructure designed to provide simple, transparent, and relatable insights into ranked results of semantic SQL queries supported by AI-DB. We introduce a new co-occurrence based interpretability approach to capture relationships between relational entities and describe a space-efficient probabilistic Sketch implementation to store and process co-occurrence counts. Our approach provides both query-agnostic (global) and query-specific (local) interpretabilities. Experimental evaluation demonstrate that our in-database probabilistic approach provides the same interpretability quality as the precise space-inefficient approach, while providing scalable and space efficient runtime behavior (up to 8X space savings), without any user intervention.
A high voltage generator utilizing a single PZT element with series-connected electrodes (2012)

This paper presents a high voltage generator utilizing a single piezoelectric element (PZT, 5 mm in diameter, 740 μm thick) with electrodes series-connected via a flexible Kapton cable. High voltage pulses over 1 kV are generated in response to transient mechanical input loads. The response of high voltage generator is evaluated for stress range from 1 MPa to 5 MPa. The high voltage generator is successfully used to operate a microdischarge-based chemical vapor sensor by providing high voltage pulses to enable microdischarge sparks across a 75 μm anode-cathode gap.
Bit Error Probability for Asynchronous Channel Access with Interference Cancellation and FBMC (2020)

Future wireless communication standards will include technologies to provide access to an increasing number of users, for example Machine-Type Communication (MTC), which is expected to interconnect billions of devices. Managing such a large number of network participants in centrally coordinated systems suffers from large controlling overhead as each device needs to be assigned resources and maintain synchronization. In this paper, we investigate systems with asynchronous channel access, in which signals are transmitted without prior resource coordination. In such uncoordinated networks, signal collisions are inevitable and pose a major challenge for system design. We present a closed-form solution for the Bit Error Probability (BEP) of colliding signals modulated with Filter Bank Multicarrier (FBMC), a modern multicarrier scheme that allows a flexible signal design. We additionally derive a solution for the BEP when Successive Interference Cancellation (SIC) is applied, a scheme where successfully decoded signals are removed from a collision in order to improve decoding of other signals implicated in the collision. The results are valid for any numbers of colliding FBMC signals over a broad range of doubly-selective channel configurations. Furthermore, we provide an overview of when interference cancellation is beneficial depending on the power ratio between colliding signals and the selected channel models.
Self-Assembled Fibers Made of Lipidporphyrinato−Zinc(II) and −Iron(II) Complexes with an Intramolecular Coordinated Axial Imidazole (1999)

Amphiphilic tetraphenylporphyrinato−metal (Zn(II), Fe(II)) derivatives with four alkylphosphocholine chains and an intramolecular coordinated axial imidazole (lipidporphyrins) produced stable colloidal solutions in water. Electron microscopy showed rodlike fibers with a uniform thickness of 10 nm, which corresponds to a double length of lipidporphyrin. The obtained fibers had some micellar characteristics and were sensitive to neither addition of electrolyte (for example, NaCl) nor change in pH. Scanning force microscopy (SFM) revealed evaporated fibers with a height of 2.8 nm on graphite. In the center of the fiber, there is probably a tetragonal tube constructed by densely packed porphyrin planes. The red shift in the broadened Soret band absorption by exciton interaction and the photophysical properties of the Zn(II) complex fibers suggested the formation of porphyrin J-aggregates. Furthermore, the first SFM images of the porphyrin fibers under liquid conditions are given. A Benesi−Hildebrand analysis revealed that the unit aggregate number for the Zn(II) complex was four, supporting a tetramer repeating structure. Fe(II) complex fibers, on the other hand, produced a kinetically stable O2 adduct reversibly at 25 °C. The coordination structures of the axial imidazole and O2 molecule in the Fe(II) complex have been clarified by resonance Raman spectroscopy. The O2-binding equilibrium and kinetic parameters were also evaluated.
Wasseraufbereitung (2006)

Wasserkreisläufe – Spiralwickelmodule Einleitung Aufbau eines Spiralwickelmoduls Fouling in Spiralwickelmodulen Spiralwickelmodule in Anlagen Beispiele für die Verwendung von Spiralwickelmodulen in Wasserkreisläufen Zusammenfassung und Konklusion Literatur Vacuum Rotation Membrane (VRM) – das rotierende Membranbelebungsverfahren: Aufbau und Betrieb Einleitung Theorie Membranbelebungsverfahren nach dem Niederdruckprinzip VRM-Verfahren Betriebserfahrungen mit VRM-Anlagen Abwasserreinigungsanlage Schwägalp (kommunales Abwasser) Klarfiltration von Brauereiabwasser (Pilotierung) Prozesswasseraufbereitung mit CR-Filtertechnologiee Einleitung Technische Beschreibung des CR-Filters Filteraufbau Funktionsprinzip des CR-Filters CR-Filtertypen Trennbereich des CR-Filters Anlagenkonzepte Anwendungsbeispiele Aufbereitung von Prozesswasser aus der Textilproduktion Aufbereitung von Prozesswasser aus der PVC-Produktion Aufbereitung von Streichfarbenspülwasser Zusammenfassung Literatur