gebhart/patrepeval huggingface dataset:
A self-paced fuzzy tracking controller for two-dimensional motion control (1990)

A heuristic controller is presented that takes the form of a set of fuzzy linguistic rules. Simulations show that the fuzzy logic controller (FLC) yields better results than the conventional PD controller. A self-paced fuzzy tracking controller (SPFTC) designed for two-dimensional path tracking is also presented. The SPFTC adjusts the tracking speed in accordance with contour conditions such as curvature; the fuzzy-rule-based adjustment of the tracking speed improves performance in terms of tracking precision and travel time. Advantages of the FLC and SPFTC are demonstrated by a simulation study.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Semen-Derived Enhancer of Viral Infection (SEVI) Binds Bacteria, Enhances Bacterial Phagocytosis by Macrophages, and Can Protect against Vaginal Infection by a Sexually Transmitted Bacterial Pathogen (2013)

The semen-derived enhancer of viral infection (SEVI) is a positively charged amyloid fibril that is derived from a self-assembling proteolytic cleavage fragment of prostatic acid phosphatase (PAP(248-286)). SEVI efficiently facilitates HIV-1 infection in vitro, but its normal physiologic function remains unknown. In light of the fact that other amyloidogenic peptides have been shown to possess direct antibacterial activity, we investigated whether SEVI could inhibit bacterial growth. Neither SEVI fibrils nor the unassembled PAP(248-286) peptide had significant direct antibacterial activity in vitro. However, SEVI fibrils bound to both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli and Neisseria gonorrhoeae) bacteria, in a charge-dependent fashion. Furthermore, SEVI fibrils but not the monomeric PAP(248-286) peptide promoted bacterial aggregation and enhanced the phagocytosis of bacteria by primary human macrophages. SEVI also enhanced binding of bacteria to macrophages and the subsequent release of bacterially induced proinflammatory cytokines (tumor necrosis factor alpha [TNF-α], interleukin-6 [IL-6], and IL-1β). Finally, SEVI fibrils inhibited murine vaginal colonization with Neisseria gonorrhoeae. These findings demonstrate that SEVI has indirect antimicrobial activity and that this activity is dependent on both the cationic charge and the fibrillar nature of SEVI.
Augmentation of M‐Current and Increased Synaptic Efficacy at Intrinsic Cardiac Neurons Contributes to an Enhanced Cardiac Responsiveness to Vagal Nerve Stimulation in the Infarcted Porcine Heart (2018)

Imbalances to autonomic regulation of cardiac function contribute to risk for arrhythmia after myocardial infarction (MI). We tested the hearts responsiveness to vagal nerve stimulation (VNS), 8 wks after MI, to determine if parasympathetic control of the heart is altered in MI pigs. A significantly greater bradycardic response was elicited in MI animals during 20Hz stimulation. Intracellular voltage recordings from whole‐mount preparations of intrinsic cardiac neurons (ICNs) were subsequently used to assess whether alterations in neuronal membrane properties or synaptic transmission underlie the observed increase in responsiveness to VNS in MI animals. General membrane properties (resting membrane potential, input resistance, action potential amplitude/duration, afterhyperpolarization amplitude/duration) of ICNs from control and MI pigs were not different, but ICN excitability was significantly depressed in MI pigs. Testing synaptic efficacy revealed a greater proportion of strong (high AP probability) vs weak synapses (low AP probability) in MI animals. Tetanic stimulation (20Hz) of interganglionic nerve bundles elicited slow excitatory postsynaptic potentials (sEPSPs) in a significantly greater subset of MI ICNs (10/22) vs controls (4/26). The sEPSP persisted in hexamethonium (500uM) but was blocked by atropine (1uM), indicating mediation by cholinergic inhibition of M‐current. Application of 1mM Ba 2+ increased excitability of ICNs from both control and MI animals further supporting a role for M‐current in the regulation of porcine ICN excitability. In hexamethonium, the amplitude of the sEPSP was significantly greater in MI ICNs. In conclusion, we identify a important role of M‐current in the regulation of the excitability of porcine ICNs, and demonstrate enhanced membrane depolarization of ICNs from MI animals after presynaptic stimulation due, in part, to greater inhibition of I M during tetanic nerve stimulation which may underlie the enhanced sensitivity to VNS in MI pigs. Support or Funding Information This work was supported in part by NIH grant OT2OD023848. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
Cometabolic Treatment of 1,4-Dioxane in Biologically Active Carbon Filtration with Tetrahydrofuran and Propane at Relevant Concentrations for Potable Reuse (2023)

1,4-Dioxane is a probable human carcinogen and a widely occurring water contaminant. Cometabolic biodegradation of 1,4-dioxane could potentially provide a cost-effective and efficient treatment, but research is needed to establish its viability for water reuse purposes. The purpose of this study was to compare propane versus tetrahydrofuran as cometabolites for enhancing the removal of 1,4-dioxane via biologically active carbon filtration (BAF) as part of a pilot-scale water reuse system. Removal of 10, 5, 1, and 0.3 μg/L of 1,4-dioxane by BAF was examined in systems amended with either propane (2 mg/L) or tetrahydrofuran (25–50 μg/L), receiving the same ozonated, secondary wastewater effluent. At the lowest influent 1,4-dioxane concentration (0.3 μg/L), the tetrahydrofuran amended filter removed on average 58% ± 4% (std dev) of the incoming 1,4-dioxane. During the same period, the propane amended filter removed on average 74% ± 7% of the incoming 1,4-dioxane and at times degraded the 1,4-dioxane to below the method detection limit of 0.06 μg/L. This study demonstrates that amending cometabolites prior to BAF is a feasible treatment technique for removal of 1,4-dioxane occurring at submicrogram per liter concentrations and thus holds promise for both potable reuse applications and drinking water treatment.
Efficient Data Migration in Self-managing Storage Systems (2006)

Self-managing storage systems automate the tasks of detecting hotspots and triggering data migration to alleviate them. This paper argues that existing data migration techniques do not minimize data copying overhead incurred during reconfiguration, which in turn impacts application performance. We propose a novel technique that automatically detects hotspots and uses the bandwidth-to-space ratio metric to greedily reconfigure the system while minimizing the resulting data copying overhead. We validate our technique with simulations and a prototype implemented into the Linux Kernel. Our prototype and simulations show our algorithm successfully eliminates hotspots with a factor of two reduction in data copying overhead compared to other approaches.
Laser spike annealing for nickel silicide formation (2011)

Recent work has shown that laser annealing may have advantages over conventional RTP for nickel silicidation formation, such as lower leakage and better device performance. However, there are a number of requirements that must be met by any millisecond annealing tool to successfully bring this process to a high volume manufacturing environment. Ultratech's new low-temperature LSA system is designed to meet these requirements for middle-of-line processes such as nickel silicidation. Specifically, this system meets the requirements of within-die temperature uniformity, layout-independent processing, and closed-loop temperature control. Supporting data is presented for each of these requirements. Characterization data on blanket NiPt wafers is also presented which shows that a large step size can be used during the rastoring of the laser beam over across the wafer, enabling a production-worthy throughput of 70wph to be achieved by LSA.
Creation and Study of a Model Cobalt Catalyst for High-Performance Fischer–Tropsch Synthesis Using Nonporous Carbon Fiber as a Support (2022)

A cobalt catalyst was manufactured using polyacrylonitrile (PAN)-based carbon fiber as a support. The surface of the fiber was covered with thin layer of alumina before cobalt impregnation. The catalyst was studied by a number of physicochemical methods including low-temperature nitrogen adsorption, TPR, DTG, chromatography, electron microscopy (TEM and SEM) and thermal conductivity measurements. The properties measured were discussed along with data on the activity in Fischer–Tropsch synthesis. It was found that the catalyst after the synthesis becomes significantly different from the starting catalyst, mostly because of the deposition and accumulation of high-molecular products of the Fischer–Tropsch synthesis. At the same time, in the steady-state mode, its catalytic parameters correspond to a high-performance granular catalyst based on graphite, which allows us to use the results obtained as a model for identifying the surface states of a porous catalyst of the new generation gas-to-liquid (GTL) process.
A Prospective Randomized Trial of Mini-incision Posterior and Two-incision Total Hip Arthroplasty (2010)

We found no differences in perioperative outcomes between these two approaches for THA. Variables other than the surgical approach including perioperative protocols, patient expectations, and the patient's general health may have a greater effect on outcomes such as pain during the early postoperative period, functional recovery, and length of hospital stay. The use of small incisions for THA was safe as was a shortened hospital stay in selected patients.
Synergistic Interactions of Indole-2-Carboxamides and β-Lactam Antibiotics against Mycobacterium abscessus (2020)

New drugs or therapeutic combinations are urgently needed against <i>Mycobacterium abscessus</i> Previously, we demonstrated the potent activity of indole-2-carboxamides 6 and 12 against <i>M. abscessus</i> We show here that these compounds act synergistically with imipenem and cefoxitin <i>in vitro</i> and increase the bactericidal activity of the β-lactams against <i>M. abscessus</i> In addition, compound 12 also displays synergism with imipenem and cefoxitin within infected macrophages. The clinical potential of these new drug combinations requires further evaluation.
Glyoxalase I disruption and external carbonyl stress impair mitochondrial function in human induced pluripotent stem cells and derived neurons (2021)

Carbonyl stress, a specific form of oxidative stress, is reported to be involved in the pathophysiology of schizophrenia; however, little is known regarding the underlying mechanism. Here, we found that disruption of GLO1, the gene encoding a major catabolic enzyme scavenging the carbonyl group, increases vulnerability to external carbonyl stress, leading to abnormal phenotypes in human induced pluripotent stem cells (hiPSCs). The viability of GLO1 knockout (KO)-hiPSCs decreased and activity of caspase-3 was increased upon addition of methylglyoxal (MGO), a reactive carbonyl compound. In the GLO1 KO-hiPSC-derived neurons, MGO administration impaired neurite extension and cell migration. Further, accumulation of methylglyoxal-derived hydroimidazolone (MG-H1; a derivative of MGO)-modified proteins was detected in isolated mitochondria. Mitochondrial dysfunction, including diminished membrane potential and dampened respiratory function, was observed in the GLO1 KO-hiPSCs and derived neurons after addition of MGO and hence might be the mechanism underlying the effects of carbonyl stress. The susceptibility to MGO was partially rescued by the administration of pyridoxamine, a carbonyl scavenger. Our observations can be used for designing an intervention strategy for diseases, particularly those induced by enhanced carbonyl stress or oxidative stress.
30.2 A 161mW 56Gb/s ADC-Based Discrete Multitone Wireline Receiver Data-Path in 14nm FinFET (2019)

The increasing demand on bandwidth for communicating among processors through wired interconnects in large-scale servers motivates the increase in the lane-data-rate from the current 28Gb/s to 56Gb/s or further. Recently published works [1-3] demonstrated ADC-based receiver (RX) prototypes equalizing >56Gb/s PAM-4 symbols for legacy channels with pre-FEC BERs of less than 2E4 satisfying IEEE p802.bj/bs pre-FEC BER requirements. While the ADC-based >56Gb/s PAM-4 RXs provide strong equalization performance using a large number of feed-forward equalization (FFE) taps and a few decision-feedback equalization (DFE) taps [1,2] implemented in digital, their power consumption remains excessive due to heavy arithmetic operations in the DSP.
Dermorphin Reduces the Metyrapone-Evoked Release of Adrenocorticotropin, β-Endorphin, and β-Lipotropin in Man** (1985)

The aim of this study was to investigate further the influence of dermorphin (D), a new potent opioid peptide (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), on the functional activity of the pituitary-adrenocortical system in man. Six normal men were treated with oral metyrapone to stimulate the secretion of ACTH, β-lipotropin, and β-endorphin. In these subjects, significant suppression of metyrapone-evoked release of ACTH and related peptides occurred during D infusion (5.5 μ/kg-min for 30 min) compared with that during saline infusion. These results indicate that D can induce a significant decline in plasma levels of ACTH, β-lipotropin, and β-endorphiri, the major circulating peptides from the C-terminal part of proopiocortin, and suggest that opioid peptides may be involved in the control of the functional activity of pituitary-adrenocortical activity in man
The apolipoprotein E allele epsilon 4 does not correlate with the number of senile plaques or neurofibrillary tangles in patients with Alzheimer's disease. (1996)

No correlation was found between the number of apo epsilon 4 alleles and the number of senile plaques and neurofibrillary tangles in the hippocampus or the frontal cortex of patients with Alzheimer's disease, or vascular dementia, or control groups. No significant differences in duration or severity of dementia were found between patients with or. without the apo epsilon 4 allele. No increased frequency of apo epsilon 4 was found in vascular dementia. CONCLUSION AND COMMENT: Although the apo epsilon genotype clearly affects whether Alzheimer's disease will develop or not, the present study suggests that it has no influence on pathology or clinical intellectual status, once the dementia has manifested itself. No increased apo epsilon 4 allele frequency was found in neuropathologically diagnosed patients with vascular dementia in whom concomitant Alzheimer's disease can be excluded.
O2.3. AUTOMATED ANALYSIS OF RECENT-ONSET AND PRODROMAL SCHIZOPHRENIA (2018)

Psychosis has significant effects on language, to the extent that its disturbance is one of the principal components of diagnosis and prognosis. In particular, two features of language seem to be prominently affected: discourse coherence, observed in patients as derailment (or tangentiality), and discourse richness, observed as poverty of speech. Using automated linguistic analysis on baseline interviews, we have shown in a previous study that it is possible to predict with high accuracy of conversion to psychosis (100%) among a cohort of clinical high-risk youth, by quantifying the subjects’ semantic coherence and syntactic complexity as proxies for derailment and poverty of speech, respectively.1 In the present study, we seek to explore to what extent the prodromal prediction model can discriminate recent-onset schizophrenia patients from matching controls, with the intent of understanding how the prodromal-onset transition is reflected in language. Eighteen recent-onset schizophrenic patients and twelve matching controls had baseline interviews, using an open-ended protocol previously introduced.2 Using automated analysis, transcripts of interviews were evaluated for semantic and syntactic features predicting psychosis onset in an independent cohort. These features were then used to discriminate between patients and controls, applying the same classifier that predicted conversion to psychosis, namely converts laying outside the convex hull of non-converts. Additionally, we compared the discrimination power of this approach against alternative models including alternative linguistic features (e.g. metaphoricity3) and protocols (e.g. short prompts4). The convex hull of the controls subjects misclassifies only one of the patient samples, a result that amounts to 95% true positive rate. Surrogating by label randomization and accounting for false and positive negative rates results in a balanced accuracy of 80%, which is comparable to those obtained with alternative automated models, which range from 70% to 85%. Moreover, the present cohort is clearly separable from both converts and non-converts in the CHR cohort when projected in the feature space. The automated features optimized for prediction of psychotic onset convey highly significant information regarding the discrimination between recent-episode patients and controls. The directionality of effects, however, is not obviously derived from that observed in the prodromal-onset transition. This preliminary study provides the basis for a larger study to better understand language disturbances across these cohorts. 1.Bedi, G., et al. npj Schizophrenia 1 (2015): 15030. 2. Ben-David, S., et al. Psychiatric Services 65.12 (2014): 1499–1501. 3. Gutiérrez, E.D., et al. Proceedings of the 2017 Conference on Empirical Methods in Natural Language Processing. 2017. 4. Mota, N.B., et al. PloS one 7.4 (2012): e34928.
Investigation of PUCCH structure with SRS transmission based on BS-CDMA for LTE-Advanced carrier aggregation (2011)

In LTE-Advanced, carrier aggregation (CA) employing multiple component carriers (CCs) is supported, and multiple acknowledgement (ACK)/ negative ACK (NACK) bits associated with multiple CCs are required. In order to convey multiple ACK/NACK bits for downlink CA, a physical uplink control channel (PUCCH) based on block spread code division multiple access (BS-CDMA) is used in the LTE-Advanced uplink. There are two PUCCH structures depending on the presence of a sounding reference signal (SRS), which is used to measure the uplink channel quality. In the subframe with SRS transmission, the last symbol in each PUCCH is removed to avoid simultaneous transmissions of the ACK/NACK and SRS so that the single-carrier property is sustained. In this paper, we investigate the optimum PUCCH structure with SRS transmission based on BS-CDMA in the uplink. We propose two schemes: one removes the ACK/NACK symbol and the other removes the demodulation RS symbol. The ACK/NACK performance for these two schemes is evaluated by computer simulation considering discontinuous transmission (DTX) detection at the base station receiver.
P-Chirogenic Monodentate Phosphine Ligands Bearing 2-Biphenyl Group (2001)

Optically pure P-chirogenic monodentate phosphine ligands, [(S)-(2-biphenyl)(tert-butyl)methylphosphine ((S)-3a], (R)-(2-biphenyl)cyclohexylmethylphosphine [(R)-3b], and (S)-(2biphenyl)methylphenylphosphine [(S)-3c] were synthesized via phosphine-borane intermediates. Palladium-catalyzed asymmetric allylic alkylation using (S)-3a and (R)-3b as the chiral ligands afforded products with the same absolute configuration in high enantioselectivity.
Optical design of an ultrashort throw ratio projector with two freeform mirrors (2016)

In this work, an optical design approach is presented to design an ultrashort throw distance projection system by combination of an off-the-shelf refractive lens and two off-axis freeform mirrors. These two freeform mirrors are used to greatly shorten the projection distance by more than three times compared to conventional (rotationally symmetric) systems, while still maintaining a good imaging quality. Firstly, a direct design method that enables the simultaneous calculation of two off-axis freeform-profile mirrors by partially coupling more than three fields is introduced. The specifications of the conventional refractive lens are taken into account during this procedure. The pupil matching principle is applied to ensure good performance between the two sub-systems. The calculated mirrors then serve as a good starting point for optimization using commercial optical design software. To step from freeform profiles to freeform surfaces, the calculated two profiles are fitted into odd polynomials to evaluate the image quality and then re-fitted into XY polynomials for further optimization. Finally, the polynomial coefficients of the two freeform mirrors are imported into the optical design program. The merit function is built from RMS spot radii over the full field, and additional constraints are made for correcting distortion. After optimization, the calculated initial design quickly converges to a well performing imaging system. As an example, an ultrashort throw distance projection lens with a large 80-inch diagonal image at 400mm throw distance is designed, analyzed and compared with literature data. The values of MTF are over 0.6 at 0.5 lp/mm and the distortion is less than 1.5%: showing a very good and well balanced imaging performance over the entire field of view.
Recent Development to Explore the Use of Biodegradable Periodic Mesoporous Organosilica (BPMO) Nanomaterials for Cancer Therapy (2020)

Porous nanomaterials can be used to load various anti-cancer drugs efficiently and deliver them to a particular location in the body with minimal toxicity. Biodegradable periodic mesoporous organosilica nanoparticles (BPMOs) have recently emerged as promising candidates for disease targeting and drug delivery. They have a large functional surface and well-defined pores with a biodegradable organic group framework. Multiple biodegradation methods have been explored, such as the use of redox, pH, enzymatic activity, and light. Various drug delivery systems using BPMO have been developed. This review describes recent advances in the biomedical application of BPMOs.
Effect of growth temperature and post-growth thermal annealing on carrier localization and deep level emissions in GaNAs∕GaAs quantum well structures (2005)

We report results from investigation of the optical properties of GaNAs∕GaAs quantum well structures. The structures were grown by molecular-beam epitaxy at different temperatures, and subsequently postgrowth thermal treatments at different temperature were performed. The results show that the carrier localization is smaller in a structure grown at a temperature of 580°C in comparison with a structure grown at 450°C. Both structures also show a broaden deep level emission band. Furthermore, the deep level emission band and the carrier localization effect can be removed by thermal annealing at 650°C in the structure grown at 450°C. The structure quality and radiative recombination efficiency are significantly improved after annealing. However, annealing under the same condition has a negligible effect on the structure grown at 580°C.