gebhart/patrepeval huggingface dataset:
Combined Use of Nearfield Hydrophones and Multiple Migration for Shallow Imaging (2022)

Abstract Modern acquisition approaches are moving towards ocean bottom node (OBN) designs. By acquiring hydrophone and geophone data, wavefield separation of these data provides access to up-going and down-going wavefields, and powerful techniques such as up/down deconvolution can be employed to attenuate surface related multiples and the source wavelet. In shallow water regions, however, very shallow reflections are not recorded. This paper will illustrate how we can derive an image of the shallow subsurface jointly using near field hydrophone (NFH) data and multiple imaging. Traditionally used for source firing QC, NFH data are gaining popularity for shallow imaging. Typically recorded with a sample interval of 1 ms or less, NFH recordings are higher frequency than OBN data, which are normally limited to 250 Hz. In very shallow water regions, NFHs mounted on the inactive source array may only record beyond-critical arrivals which have limited use for shallow imaging. In this paper, we will demonstrate the use of NFH recordings mounted on the firing array to overcome this problem. However, NFH data on the firing array often suffer difficulties when recovering low frequency reflections due to the extremely strong direct arrival. In addition, processes such as source deghosting and demultiple may be challenging due to the single-fold nature of the data. Another method that is gaining popularity for shallow imaging is multiple migration. Compared to imaging with primaries, multiple imaging provides a larger illumination area with smaller incident angles. We propose to combine the low frequencies from multiple imaging with the high frequencies from NFH imaging to provide a high-resolution image of the shallow section. To illustrate this, we use a shallow water OBN dataset acquired offshore Abu Dhabi in water depths of 3 m to 50 m, where complementary information provided by NFH imaging and multiple migration, and the combination of these images, has resulted in a broadband shallow subsurface section with improved spatial continuity and reduced sidelobes.
Investigating Public Health Surveillance using Twitter (2015)

Microblog services such as Twitter are an attractive source of data for public health surveillance, as they avoid the legal and technical obstacles to accessing the more obvious and targeted sources of health information. Only a tiny fraction of tweets may contain useful public health information but in Twitter this is offset by the sheer volume of tweets posted. We present a system which can identify medical named entities in a real-time stream of Twitter posts and determine their geographic locations, as well as preliminary experiments in using this information for health surveillance purposes.
Electrochemical investigations into ferrocenylphosphonic acid functionalized mesostructured porous nanocrystalline titanium oxide films (2006)

Titanium dioxide nanocrystalline mesoporous thin films were prepared by the evaporation induced self assembly process onto a SnO2–F (FTO) electrode and post-functionalized by ferrocenylphosphonic acid as a grafted electrochemical probe. We showed that the pseudo-diffusive electron hopping between the redox species is related to the specific order of the TiO2 layer mesoporosity. The electrochemical measurements exhibit a very unusual behavior for a modified electrode as far as the slopes of the log Ivs. log t curves are concerned, featuring a charge transfer occurring in a strongly anisotropic medium. The electronic diffusion coefficient values have been determined and fit well with results obtained for similar materials using soluble redox probes. This study demonstrates that efficient charge transfer can be driven when organic components are grafted onto the porous surface of mesotructured TiO2 semiconducting films.
64‐1: Lensless Microscope Using High‐Resolution Display (2019)

We devise a lensless microscope as an application of high‐resolution displays. Images were taken at a resolution corresponding to the pixel size with the use of an existing display. An operation scheme for fast driving is suggested.
ALPHA-FETOPROTEIN IN ABORTION (1973)

Department II of Obstetrics and Gynaecology, University Central Hospital, SF-00290, Helsinki 29, Finland
Novel patching mechanism by using multi-homing (2009)

Multicast patching is one of the techniques to reduce the burden of a video on demand (VOD) server. A novel patching mechanism by using multi-homing has placed its logical channel into another network interface of a client terminal. The performance of proposed patching mechanism is presented via numerical analysis. In summary, our proposed scheme modifies multicast patching model using extended client buffer and proxy.
Robust Action Governor for Uncertain Piecewise Affine Systems with Non-convex Constraints and Safe Reinforcement Learning (2022)

The action governor is an add-on scheme to a nominal control loop that monitors and adjusts the control actions to enforce safety specifications expressed as pointwise-in-time state and control constraints. In this paper, we introduce the Robust Action Governor (RAG) for systems the dynamics of which can be represented using discrete-time Piecewise Affine (PWA) models with both parametric and additive uncertainties and subject to non-convex constraints. We develop the theoretical properties and computational approaches for the RAG. After that, we introduce the use of the RAG for realizing safe Reinforcement Learning (RL), i.e., ensuring all-time constraint satisfaction during online RL exploration-and-exploitation process. This development enables safe real-time evolution of the control policy and adaptation to changes in the operating environment and system parameters (due to aging, damage, etc.). We illustrate the effectiveness of the RAG in constraint enforcement and safe RL using the RAG by considering their applications to a soft-landing problem of a mass-spring-damper system.
Peptide delivery with poly(ethylene glycol) diacrylate microneedles through swelling effect (2017)

Transdermal delivery of therapeutic biomolecules (including peptides) can avoid enzymatic digestion that occurs in the oral route. (Polyethylene glycol) diacrylate (PEGDA)-based microneedles, with good biocompatibility, are easily fabricated through photo-polymerization with a precisely controlled structure. It has successfully been used for the transdermal delivery of small molecule drugs such as 5-fluorouracil. However, the delivery of peptide-based therapeutics using this platform is seldom reported. This is because of the potential damage to the peptide during the photo-polymerization process of PEGDA. Herein, we introduce a method to load PEGDA microneedles with peptides without compromising peptide potency. Using gap junction inhibitor (Gap 26) as an example, the peptide was loaded into PEGDA microneedles through the swelling effect of PEGDA in the aqueous solution. The peptide-loaded microneedles were applied to a keloid scar model and exhibited inhibition expression of collagen I, a predominant marker of keloid scar, demonstrating its potential therapeutic effects.
High Cholesterol Content and Decreased Membrane Fluidity in Human Spermatozoa Are Associated With Protein Tyrosine Phosphorylation and Functional Deficiencies (2009)

Poor-quality sperm show reduced capacity to undergo capacitation-induced protein tyrosine phosphorylation and hyperactivation. Given that these deficiencies can be overcome by membrane-permeant stimulators of the cAMP-dependent kinase system, we hypothesize that the main defect underlying these deficiencies resides on the sperm plasma membrane. Spermatozoa from semen samples obtained from 15 consenting healthy donors were separated in 2 subpopulations, L45 (first interface) and L90 (pellet), using a 45:65:90 ISolate gradient centrifugation method. These sperm fractions were studied before and after a 6-hour capacitating incubation for sperm motion parameters (computer-assisted analysis), including hyperactivation, protein tyrosine phosphorylation (immunofluorescence), membrane fluidity (Laurdan fluorescence), and sterol and phospholipid content (high-performance thin-layer chromatography). In summary, data indicate that L45 (poor-motility) spermatozoa present an excess of cholesterol and desmosterol, which impairs the normal increase in membrane fluidity during capacitation and its consequent activation of protein tyrosine phosphorylation and hypermotility. Therefore, a defect in membrane composition and dynamics is underlying human sperm biochemical and functional deficiencies related to inadequate capacitation.
Introduction of transition-metal ions into cation positions in high-silica zeolites by solid-state reactions. III. The simultaneous introduction of multivalent ions in HZSM 5 seolite (1987)

The possibility of simultaneously introducing ions of Cu(II), Cr(V), and V(IV) into cation positions in ZSM 5 zeolite by reactions in the solid state has been studied. It was shown that following calcination of HZSM 5 and CuCrO/sub 4/ in air a superposition of two EPR spectra was observed that are characteristic of isolated Cu(II) and Cr(V) ions, i.e., isolated ions of the two metals are statistically distributed in the cation positions of the zeolite. Upon successive interaction of the HZSM 5 with CrO/sub 3/ and then with CuO, a significant fraction of the Cr(V) ions originally occupying cation positions are replaced by Cu(II) ions. Upon successive interaction in air between HZSM 5 and V/sub 2/O/sub 5/ and CuO, no less than 90% of the V(IV) ions are replaced by Cu(II) ions in cation positions. Heating this sample at 400/sup 0/C in H/sub 2/ results in the reduction of the Cu(II) ions and their expulsion from cation positions, which remain unoccupied. Raising the temperature to 800/sup 0/C in H/sub 2/ results in the cation positions again being occupied by V(IV) ions.
Oncogenic activation of the tyrosine kinase domain of the human trk proto-oncogene by fusion to a cell adhesion molecule. (1996)

To investigate the mechanisms of radiation-induced neoplastic conversion, DNA from X-ray transformed human epidermal keratinocytes (RHEK-1) was used in sequential cycles of NIH3T3 transfection followed by nude mice tumorigenicity assays. NIH3T3-derived transformants retained discrete DNA fragments hybridizing to human alu probes. Four clones were isolated from a cosmid library prepared from one of these transformants (49-7G) using human DNA as the probe. Analyses of DNAs from 49-7G cells and the four cosmid clones with probes for a number of human oncogenes demonstrated that the cloned sequences were related to the trk oncogene. Transfection of NIH3T3 cells with the cosmid DNAs did not result in the appearance of transformed foci when the murine fibroblasts were cultured on plastic. However, foci developed when transfected cells were cultured on plates coated with various extracellular matrix (ECM) components. Neomycin-resistant cosmid-transfected NIH3T3 cells did induce tumors in nude mice, and their tumorigenicity correlated with their level of trk expression. Nucleotide sequence analyses of cDNA clones isolated from a 49-7G library with a human trk probe revealed that the cloned sequences resulted from the fusion between 5' sequences from the human beta-1,4-galactosyltransferase gene, which encodes a membrane protein involved in cell-cell and cell-matrix interactions, and 3' sequences from the human trk proto-oncogene. The 76 kDa protein product of the chimeric gene, designated bgt-trk, has been identified in NIH3T3 cells transfected with cosmid 19/2 or with bgt-trk cDNA expression constructs, and its phosphorylation in tyrosine has been found to increase when the transfected cells were seeded on plates coated with ECM components which also elicited foci formation in NIH3T3 transformation assays. The fusion of the trk tyrosine kinase domain to a cell adhesion molecule may explain the ECM dependence for the expression of the full transforming potential of the resulting oncogene product.
Manipulation of the Longitudinal Profile (2006)

We present studies of transverse emittances and electron beam pulse length for various operating points of the electron source: electron beam charge, laser length and spot size, and solenoid settings. We especially study the impact, on transverse emittance, of short Gaussian versus long square temporal distributions of the photocathode drive‐laser.
Rat platelets contain glycosylated and non‐glycosylated forms of platelet factor 4 (1994)

Platelet factor 4 is a heparin-binding protein released from the alpha granules of activated platelets. This study describes the purification and identification of two forms of rat platelet factor 4, the previously characterized non-glycosylated form of 7 kDa and an additional glycosylated form of molecular mass 9 kDa. The two proteins both neutralized the antithrombin-III-dependent inhibitory activity of heparin. Although their amino acid composition was found to be the same, in the N-terminal sequence of the 9-kDa protein, the second threonine residue could not be detected and a difference of 976Da was determined by mass spectrometry. After digestion with O-glycanase and sialidase, the two proteins showed the same molecular mass. Overall consideration of these data led to identification of the higher-molecular-mass protein as a glycosylated form of rat platelet factor 4 with O-glycosylation at the second N-terminal amino acid, while the structure of the oligosaccharide core was established by mass spectrometry and sugar differentiation with lectins. The two forms of platelet factor 4 are both present in platelets and secreted after platelet activation.
Difference in dummy responses in matched side impact tests of vehicles with and without side airbags (2015)

The curtain and torso side airbags effectively reduced biomechanical responses for the head and chest in 50 km/h side impacts with a high-hooded deformable barrier. The reductions in the IIHS tests are directionally the same as estimated fatality reductions in field crashes reported by NHTSA for side airbags.
Optical Link on Silicon Employing Ge/SiGe Quantum Well Structures (2007)

We demonstrate an optical link on silicon employing Ge/SiGe quantum well waveguide modulators and photodetectors. Modulators show >3 dB contrast ratio for <6 V drive for a 22 nm wavelength range. Photodetectors show external responsivity up to 0.26 A/W and high-speed detection at 2.5 Gb/s.
24‐3: An 8.34‐inch 1058‐ppi 8K x 4K Flexible OLED Display (2017)

We have successfully fabricated an 8.34‐inch 1058‐ppi 8K x 4K flexible organic light‐emitting diode (OLED) display. It exhibits the world’s highest resolution and pixel density among flexible OLED displays, offering excellent viewing‐angle characteristics owing to the arrangement of subpixels in a zigzag pattern.
Liver Receptor Homolog-1 Regulates Bile Acid Homeostasis but Is Not Essential for Feedback Regulation of Bile Acid Synthesis (2008)

Liver receptor homolog 1 (LRH-1), an orphan nuclear receptor, is highly expressed in liver and intestine, where it is implicated in the regulation of cholesterol, bile acid, and steroid hormone homeostasis. Among the proposed LRH-1 target genes in liver are those encoding cholesterol 7alpha-hydroxylase (CYP7A1) and sterol 12alpha-hydroxylase (CYP8B1), which catalyze key steps in bile acid synthesis. In vitro studies suggest that LRH-1 may be involved both in stimulating basal CYP7A1 and CYP8B1 transcription and in repressing their expression as part of the nuclear bile acid receptor [farnesoid X receptor (FXR)]-small heterodimer partner signaling cascade, which culminates in small heterodimer partner binding to LRH-1 to repress gene transcription. However, in vivo analysis of LRH-1 actions has been hampered by the embryonic lethality of Lrh-1 knockout mice. To overcome this obstacle, mice were generated in which Lrh-1 was selectively disrupted in either hepatocytes or intestinal epithelium. LRH-1 deficiency in either tissue changed mRNA levels of genes involved in cholesterol and bile acid homeostasis. Surprisingly, LRH-1 deficiency in hepatocytes had no significant effect on basal Cyp7a1 expression or its repression by FXR. Whereas Cyp8b1 repression by FXR was also intact in mice deficient for LRH-1 in hepatocytes, basal CYP8B1 mRNA levels were significantly decreased, and there were corresponding changes in the composition of the bile acid pool. Taken together, these data reveal a broad role for LRH-1 in regulating bile acid homeostasis but demonstrate that LRH-1 is either not involved in the feedback regulation of bile acid synthesis or is compensated for by other factors.
A Pseudo-Rigid-Body Model of the Human Spine to Predict Implant-Induced Changes on Motion (2011)

Injury, instrumentation, or surgery may change the functional biomechanics of the spine. Adverse changes at one level may affect the adjacent levels. Modeling these changes can increase the understanding of adjacent-level effects and may help in the creation of devices that minimize adverse outcomes. The current modeling techniques (e.g., animal models, in vitro testing, and finite element analysis) used to analyze these effects are costly and are not readily accessible to the clinician. It is proposed that the pseudo-rigid-body model(PRBM) may be used to accurately predict adjacent level effects in a quick and cost effective manner that may lend itself to a clinically relevant tool for identifying the adjacent-level effects of various treatment options for patients with complex surgical indications. A PRBM of the lumbar spine (lower back) was developed using a compliant mechanism analysis approach. The global moment-rotation response, relative motion, and local moment-rotation response of a cadaveric specimen were determined through experimental testing under three conditions: intact, fused, and implanted with a prototype total disc replacement. The spine was modeled using the PRBM and compared with the values obtained through in-vitro testing for the three cases. The PRBM accurately predicted the moment-rotation response of the entire specimen. Additionally, the PRBM predicted changes in relative motion patterns of the specimen. The resulting models show particular promise in evaluating various procedures and implants in a clinical setting and in the early stage design process.
Immunogenetics of rheumatoid arthritis in Israel (1986)

In an attempt to study the variation of associations between HLA and rheumatoid disease a population of 44 Ashkenazi and 29 non-Ashkenazi patients with Rheumatoid Arthritis were tested for HLA-A, B, C and DR antigens and compared with the relevant control groups. In contrast to the results obtained in Middle European or North American Caucasians, Rheumatoid Arthritis in Israel is not associated with B15 and Cw3, indicating that it is very unlikely that B- and C-locus antigens are involved in coding for disease susceptibility for RA. The allele DR4 which is found associated with RA in almost all populations tested so far was in the total patient group (47.9%) slightly but not significantly more frequent than in the control group (38.3%). This difference was entirely due to a nonsignificant increase in the frequency of DR4 in the Ashkenazi patients (54.5%) compared to controls (40%), while the frequency of DR4 in non-Ashkenazi patients and controls was virtually identical (38.0% vs 36.7%). Another surprising finding was that the frequency of HLA-DR1, which has been reported to be increased in different populations of patients with RA was found to be completely normal in the present study on Israeli patients. The alleles of the Bf and the GLO system did not show any significant difference between patients and controls.(ABSTRACT TRUNCATED AT 250 WORDS)
Search for T violation in charm meson decays (2005)

Using data from the FOCUS (E831) experiment, we have searched for T violation in charm meson decays using the four-body decay channels D0→K−K+π−π+, D+→KS0K+π−π+, and Ds+→KS0K+π−π+. The T violation asymmetry is obtained using triple-product correlations and assuming the validity of the CPT theorem. We find the asymmetry values to be ATviol(D0)=0.010±0.057(stat.)±0.037(syst.), ATviol(D+)=0.023±0.062(stat.)±0.022(syst.), and ATviol(Ds+)=−0.036±0.067(stat.)±0.023(syst.). Each measurement is consistent with no T violation. New measurements of the CP asymmetries for some of these decay modes are also presented.
The Nucleome Data Bank: web-based resources to simulate and analyze the three-dimensional genome (2020)

We introduce the Nucleome Data Bank (NDB), a web-based platform to simulate and analyze the three-dimensional (3D) organization of genomes. The NDB enables physics-based simulation of chromosomal structural dynamics through the MEGABASE + MiChroM computational pipeline. The input of the pipeline consists of epigenetic information sourced from the Encode database; the output consists of the trajectories of chromosomal motions that accurately predict Hi-C and fluorescence insitu hybridization data, as well as multiple observations of chromosomal dynamics in vivo. As an intermediate step, users can also generate chromosomal sub-compartment annotations directly from the same epigenetic input, without the use of any DNA-DNA proximity ligation data. Additionally, the NDB freely hosts both experimental and computational structural genomics data. Besides being able to perform their own genome simulations and download the hosted data, users can also analyze and visualize the same data through custom-designed web-based tools. In particular, the one-dimensional genetic and epigenetic data can be overlaid onto accurate 3D structures of chromosomes, to study the spatial distribution of genetic and epigenetic features. The NDB aims to be a shared resource to biologists, biophysicists and all genome scientists. The NDB is available at https://ndb.rice.edu.
Supplementary Table S1 from A Clinical PET Imaging Tracer ([<sup>18</sup>F]DASA-23) to Monitor Pyruvate Kinase M2–Induced Glycolytic Reprogramming in Glioblastoma (2023)

&lt;p&gt;[18F]DASA-23 administered activity in healthy volunteers&lt;/p&gt;
Chromosomal organization of amplified genes in multidrug-resistant Chinese hamster cells. (1988)

Six independently derived multidrug-resistant Chinese hamster cell lines selected with vincristine, daunorubicin, actinomycin D, or colchicine were probed by in situ hybridization techniques with the cloned cDNA, p5L-18, to chromosomally localize known or presumed amplified P-glycoprotein genes. One or two clusters of amplified genes were demonstrable in all of the highly resistant sublines and were localized to homogeneously staining regions and/or abnormally banding regions, gene amplification-associated cytogenetic abnormalities, on eight different chromosomes. Analysis of trypsin-Giemsa banded karyotypes revealed additional, multiple chromosomal rearrangements that were apparently nonspecific. Mapping studies localized the native P-glycoprotein gene(s) to the region q23 to 31 (most probably band 26) on the long arm of chromosome 1 of normal Chinese hamster bone marrow fibroblasts and normal chromosome 1 homologues in resistant cells. Southern blot analysis of restriction endonuclease fragments indicated the amplification of one or both of (at least) two wild-type nonallelic genes in four of the lines and the presence in one line (DC-3F/DMM XX) of a unique 5.0-kilobase BamHI fragment resulting from a recombinational event during amplification. Comparison with the cytogenetic data indicated no correlation between restriction patterns generated by EcoRI, HindIII, PstI, or BamHI and chromosomal location of amplified genes. However, the only sublines in which the homogeneously staining region or abnormally banding region is positioned at 1q26 (at or near the site of the native gene) exhibit either alterations in gene structure (DC-3F/DM XX) or in regulation of gene expression (DC-3F/AD X), suggesting a process more complex than simply amplification of the gene in loco.