gebhart/patrepeval huggingface dataset:
The interaction of ammonium, sulfonium, and sulfide analogs of metoclopramide with the dopamine D2 receptor (1993)

A series of permanently charged ammonium and sulfonium analogues of metoclopramide as well as a permanently uncharged sulfide analogue were synthesized and evaluated for their ability to inhibit apomorphine-induced responses on mouse striatal slices. Three of the four permanently charged analogues were found to inhibit apomorphine's effects, although at higher concentrations than either metoclopramide or its dimethyl analogue. In contrast, the sulfide analogue was inactive at concentrations up to 100 microM. These findings are consistent with earlier studies of chlorpromazine and sulpiride analogues and provide further evidence that dopamine antagonists bind in their charged molecular forms to anionic sites on the D2 receptor. Further, the results of this study in conjunction with those of our earlier sulpiride study would seem to indicate that differences in the biological profiles of metoclopramide, a type 1 benzamide useful as a gastric prokinetic agent, and sulpiride, a type 2 benzamide useful for its antipsychotic effects, are not due to any appreciable differences in the binding of the basic nitrogen atom of these molecules.
Inhibition of Adrenocorticotropic Hormone Secretion in the Rat by Immunoneutralization of Corticotropin-Releasing Factor (1982)

Intravenous administration of rabbit antiserum to ovine corticotropin-releasing factor (CRF) markedly reduced the CRF-induced rise of plasma adrenocorticotropic hormone (ACTH) in intact nonstressed adult male rats while blocking more than 75 percent of the ACTH release observed in rats exposed to ether stress. Furthermore, antiserum to CRF significantly lowered ACTH levels in adrenalectomized animals. These results suggest that endogenous CRF plays a physiological role in regulating ACTH secretion.
Fully Automated Production of Diverse 18F-Labeled PET Tracers on the ELIXYS Multireactor Radiosynthesizer Without Hardware Modification (2014)

The ELIXYS radiosynthesizer facilitates rapid tracer development and is capable of producing multiple (18)F-labeled PET tracers suitable for clinical applications using the same hardware setup.
Stilbenoids Isolated from Stem Bark of Shorea hemsleyana. (2000)

Two new stilbene glucosides [(+)-alpha-viniferin 13b-O-beta-glucopyranoside and resveratrol 12-C-beta-glucopyranoside] and two new resveratrol oligomers, hemsleyanols A and B, were isolated from the bark of Shorea hemsleyana along with four known resveratrol oligomers. The structures of the isolates, including the relative configurations, were established by spectroscopic data involving long-range coupling and nuclear Overhauser effect experiments.
Cell Suspension Culture Method Using Agitation by Ultrasound Irradiation (2020)

In this study, we report a novel cell suspension culture method. When culturing large quantities of cells, suspension culture is generally used. We performed suspension culture using agitation by acoustic streaming. First, we manufactured the suspension culture devise that can generate acoustic streaming and agitate medium in a cell culture flask. Next, we performed cell culture experiments using the devise. As a result, the cell proliferation rate in the case of irradiating ultrasound was higher than that in the case of not irradiating ultrasound. Therefore, cell suspension culture can be more efficient using agitation by ultrasound irradiation.
Macromolecular Templating Approach for the Synthesis of Hydrothermally Stable Mesoporous Organosilicas with High Periodicity and Thick Framework Walls (2003)

Hydrothermally stable mesoporous ethanesilica with a long-range hexagonal order (p6mm) and a relatively thick and micropore-free framework wall was synthesized by the core−shell approach using a nonionic PEO−PLGA−PEO triblock copolymer template and a 1,2-bis(triethoxysilyl)ethane (BTESE) organosilica precursor. The pore structure and morphology were characterized by SAXS, TEM, BET, and solid-state NMR measurement. The key parameters in the synthesis of mesoporous ethanesilica with a stable thick wall are the strong contrast between the hydrophilic PEO block and the hydrophobic PLGA block and the compatibility of PEO with the BTESE organosilicate precursor at an optimum reaction temperature of 323 K. The enhanced hydrothermal stability (i.e., the structural integrity was maintained for up to 25 days in boiling water of 373 K) is believed to be due to the thick pore wall (4.2 nm), the high degree of condensation and hydrophobicity of organosilica precursor used, and the significant reduction of micropores.
SOCR data dashboard: an integrated big data archive mashing medicare, labor, census and econometric information (2015)

A client-side data import utility allows for easy and intuitive integration of user-supplied datasets. This completely open-science framework may be used for exploratory analytics, confirmatory analyses, meta-analyses, and education and training purposes in a wide variety of fields.
Specificity of the coxsackievirus B4 VP4 capsid protein investigated in silico. (2011)

The Enterovirus genus encompasses several species and various serotypes, like coxsackievirus-B1 (CV-B1) to CV-B6, and many variants. The role of these viruses, especially CV-B4, in the pathogenesis of type 1 diabetes is strongly suspected. It has been reported that antibodies directed towards the region of amino acids 11-30 of the VP4 capsid protein enhance the infection of human peripheral blood mononuclear cells with CV-B4. In order to predict the inter- and intra-serotype specificity of the region 11-30 of CV-B4 VP4, 362 available protein sequences of CV-B1 to -B6, CV-A9, and swine vesicular disease virus (SVDV) have been aligned and levels of homology have been calculated. Serine residue substitutions in this region of VP4 were observed without predictable subsequent modification of conformation or charge. The amino acids 16-24 region was the most variable. The sequence of amino acids 16-24 of the CV-B4E2 VP4 protein was highly homologous to those of other CV-B4 (64.4%) whereas there was no homology with CV-B3 and B5 and very low levels of homology with CV-B1 and B2 (3.3% and 9.9%, respectively). In conclusion, the bioinformatic analysis suggests that the region 16-24 of the VP4 capsid protein is the feature of the specificity of the target of infection-enhancing antibodies directed towards CV-B.
Detection of Green Fluorescent Protein in a Single Bacterium by Capillary Electrophoresis with Laser-Induced Fluorescence (2006)

Green fluorescence protein (GFP) is a common reporter used to monitor protein expression in single cells. However, autofluorescence from endogenous components can mask the signal from GFP, particularly at low expression levels in prokaryotes. We employ capillary electrophoresis with laser-induced fluorescence for the analysis of the expression of green fluorescent protein in a single bacterium. Capillary electrophoresis separates GFP from native cellular autofluorescent components, reducing the background signal and improving detection limits. Our system provides 100 ymol (60 copies) limits of detection for GFP. To demonstrate the performance of this instrument, we employ a model system of Deinococcus radiodurans that has been engineered to express GFP under the control of the recA promoter. We report resolution and detection of GFP and autofluorescent components in a single D. radiodurans bacterium. This paper presents the first example of expression of GFP in D. radiodurans and the first detection of GFP in a single bacterium by capillary electrophoresis.
Enhancing the Performance of UWB-Based WPANs Using Cooperative PNC Relaying (2008)

In this letter, a cooperative Piconet Coordinator (PNC) relay scheme is proposed based on a MB-OFDM system. For time domain diversity, the MB-OFDM UWB system transmits the same symbol twice in different time slots over different bands. Devices (DEVs) that are close to the PNC use it as a relay in the second transmission time. Additionally, a symbol transmission schedule is proposed to provide a sufficient time interval for cooperation. During the first transmission of the symbol, the PNC listens in on the signal from the Source Device (SDEV) to the Destination Device (DDEV) and decodes and re-encodes it with the same data rate. The PNC then transmits the signal in the second transmission as well as the SDEV. Our simulation results demonstrate the proposed cooperative PNC relay scheme can significantly improve the bit error rate (BER) performance, which translates into a power savings capability.
Evolution of Y2O3 dispersoids during laser powder bed fusion of oxide dispersion strengthened Ni-Cr-Al-Ti γ/γ’ superalloy (2021)

The successful synthesis of oxide-dispersion-strengthened (ODS) alloys via laser powder bed fusion (L-PBF) requires a better understanding of the interaction of the oxide dispersoids with the metallic melt pool. Here, a γ/γ’-strengthened Ni-8Cr-5.5Al-1Ti (wt%) model alloy is studied, as a simplified version of the commercial CM247LC alloy, by melting pre-alloyed powders in which 0.5–1 wt% Y2O3 nanoparticles were added via mechanical alloying. The Y2O3 nanoparticles follow three distinct paths. First, the strong affinity between Y2O3 and Al leads to the formation of Y4Al2O9 slag which floats on the melt pool; if in excess, the slag leads to vertically aligned mm-size cavities, preventing complete consolidation of the alloy. Second, a high number density of oxide nanodispersoids is distributed within the alloy’s grain inducing a strong (100) texture and noticeably reduces grain size compared to the unmodified base alloy. Third, despite the high stability of Y2O3, the extreme temperatures achieved in the melt pool decompose some of the Y2O3 precipitates leading to the formation of Ni- and Y-rich particles (16 nm in radius) and Y segregation to the alloy’s grain boundaries. The local composition on cracked grain boundaries is consistent with Ni17Y2 having an embrittling and liquation effect. Based on these results, the critical role of Al in reacting with oxide nanodispersoids during L-PBF manufacturing is discussed, and various types of potentially more successful dispersoids are suggested.
BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling‐dependent tumor growth in mouse models (2016)

The PI3K-AKT-mTOR signaling cascade is activated in the majority of human cancers, and its activation also plays a key role in resistance to chemo and targeted therapeutics. In particular, in both breast and prostate cancer, increased AKT pathway activity is associated with cancer progression, treatment resistance and poor disease outcome. Here, we evaluated the activity of a novel allosteric AKT1/2 inhibitor, BAY 1125976, in biochemical, cellular mechanistic, functional and in vivo efficacy studies in a variety of tumor models. In in vitro kinase activity assays, BAY 1125976 potently and selectively inhibited the activity of full-length AKT1 and AKT2 by binding into an allosteric binding pocket formed by kinase and PH domain. In accordance with this proposed allosteric binding mode, BAY 1125976 bound to inactive AKT1 and inhibited T308 phosphorylation by PDK1, while the activity of truncated AKT proteins lacking the pleckstrin homology domain was not inhibited. In vitro, BAY 1125976 inhibited cell proliferation in a broad panel of human cancer cell lines. Particularly high activity was observed in breast and prostate cancer cell lines expressing estrogen or androgen receptors. Furthermore, BAY 1125976 exhibited strong in vivo efficacy in both cell line and patient-derived xenograft models such as the KPL4 breast cancer model (PIK3CA<sup>H1074R</sup> mutant), the MCF7 and HBCx-2 breast cancer models and the AKT<sup>E17K</sup> mutant driven prostate cancer (LAPC-4) and anal cancer (AXF 984) models. These findings indicate that BAY 1125976 is a potent and highly selective allosteric AKT1/2 inhibitor that targets tumors displaying PI3K/AKT/mTOR pathway activation, providing opportunities for the clinical development of new, effective treatments.
Transformational Solar Array Final Report (2017)

We have made outstanding progress in the Base Phase towards achieving the final NASA Research Announcement (NRA) goals. Progress is better than anticipated due to the lighter than predicted mass of the IMM solar cells. We look forward to further improvements in the IMM cell performance during Option I and Option II; so, we have confidence that the first four items listed in the table will improve to better than the NRA goals. The computation of the end of life blanket efficiency is uncertain because we have extrapolated the radiation damage from room temperature measurements. The last three items listed in the Table were not intended to be accomplished during the Base Phase; they will be achieved during Option I and Option II.
Additive effects of genetic variants associated with intraocular pressure in primary open-angle glaucoma (2017)

To investigate the association between the additive effects of genetic variants associated with intraocular pressure (IOP) and IOP, vertical cup-to-disc ratio (VCDR), and high tension glaucoma (HTG) or normal tension glaucoma (NTG) as phenotypic features of primary open-angle glaucoma (POAG), and to evaluate the clinical usefulness of the additive effects of IOP-related genetic variants for predicting IOP elevation, Japanese patients with HTG (n = 255) and NTG (n = 261) and 246 control subjects were genotyped for nine IOP-related genetic variants near CAV2, GAS7, GLCCI1/ICA1, ABCA1, ARHGEF12, FAM125B, FNDC3B, ABO, and PTPRJ/AGBL2. The total number of risk alleles of these genetic variants was calculated for each participant as a genetic risk score (GRS), and the association between the GRS and the maximum IOP, mean VCDR, and phenotype (HTG or NTG) of POAG was evaluated. As the GRS increased, the maximum IOP (P = 0.012) and VCDR (P = 0.010) significantly increased. The GRS (9.1±1.9) in patients with HTG was significantly higher (P = 0.011) than that (8.7±1.8) in control subjects. The patients with GRS≥12 as a cut-off value had a 2.54 times higher (P = 0.0085) risk on HTG (maximum IOP≥22mmHg) compared with all patients. The IOP-related GRS approach substantiated that the IOP and VCDR were increased by the additive effects of IOP-related genetic variants in POAG. The high IOP-related GRS in patients with HTG but not NTG shows that there are differences in the genetic background between HTG and NTG and supports the notion that the phenotype (HTG or NTG) in patients with POAG depends on the additive effects of IOP-related genetic variants. The above-mentioned cut-off value of IOP-related GRS may be clinically useful for predicting the risk of IOP elevation.
A cytochrome b-glucose dehydrogenase chimeric enzyme capable of direct electron transfer (2021)

The development of third generation biosensors depends on the availability of direct electron transfer (DET) capable enzymes. A successful strategy is to fuse a cytochrome domain to an enzyme to fulfil the function of a built-in redox mediator between the catalytic center and the electrode. In this study, we fused the cytochrome domain of Neurospora crassa CDH IIA (NcCYT) N-terminally to glucose dehydrogenase from Glomerella cingulata (GcGDH) to generate the chimeric enzyme NcCYT-GcGDH in a large amount for further studies. Heterologous expression in P. pastoris and chromatographic purification resulted in 1.8 g of homogeneous chimeric enzyme. Biochemical and electrochemical characterization confirmed that the chimeric enzyme is catalytically active, able to perform interdomain electron transfer (IET) and direct electron transfer (DET) via the fused cytochrome domain. The midpoint redox potential of the fused b-type cytochrome is 91 mV vs. SHE at pH 6.5 and the specific current obtained on a porous graphite electrode is 2.3 μA cm<sup>-2</sup>. The high current obtained on this simple, unmodified electrode at a rather low redox potential is a promising starting point for further optimization. The high yield of NcCYT-GcGDH and its high specific activity supports the application of the chimeric enzyme in bioelectrocatalytic applications.
Bundled VM artifact to accompany paper entitled SC-Haskell: Sequential Consistency in Languages That Minimize Mutable Shared Heap (2017)

A single ".ova" file encompassing an Ubuntu-based (v. 16.04) virtual machine (VM). This VM is the "artifact" used in the artifact evaluation of the corresponding PPoPP17 paper. It contains the complete software, such as example programs and benchmark programs, necessary to reproduce the results of the paper. Scripts are included in the virtual machine to automatically run benchmarks and compare their results. Download the VM by clicking the link below under "Link(s) to data and video for this item."
Sensor networks for cognitive radio : theory and system design (2008)

Following current trends towards dynamic spectrum allocation and cognitive radio, this paper proposes a new approach and innovative techniques to support the coexistence of licensed and unlicensed wireless users in a same area. Theproposed concept, called Sensor Network aided Cognitive Radio, consists of a wireless sensor network able to assist the cognitive network by providing information on the current spectrum occupancy. This concept, that will address various operational scenarios in the future networks, involves a set of advanced wireless communications techniques like spectrum sensing, interference management, cognitive radio reconfiguration management, cooperative communications, end-to-end protocol design and cross-layer optimisation. All these enabling techniques together will form a compound system able to improve the spectrum use in a significant way. The main target scenario we consider is the use of nomadic cognitive radios in urban and suburban areas. Our objective is to develop a proof-of-concept – scheduled in 2010 – of the Sensor Network aided Cognitive Radio technology by implementing such techniques and integrating them on a hardware radio platform, which will allow us to assess the efficiency of the technology in a realistic environment.
Network Coding-Aware Queue Management for TCP Flows over Coded Wireless\n Networks (2010)

We are interested in unicast traffic over wireless networks that employ\nconstructive inter-session network coding, including single-hop and multi-hop\nschemes. In this setting, TCP flows do not fully exploit the network coding\nopportunities due to their bursty behavior and due to the fact that TCP is\nagnostic to the underlying network coding. In order to improve the performance\nof TCP flows over coded wireless networks, we take the following steps. First,\nwe formulate the problem as network utility maximization and we present a\ndistributed solution. Second, mimicking the structure of the optimal solution,\nwe propose a "network-coding aware" queue management scheme (NCAQM) at\nintermediate nodes; we make no changes to TCP or to the MAC protocol (802.11).\nWe demonstrate, via simulation, that NCAQM significantly improves TCP\nperformance compared to TCP over baseline schemes.\n
Self-correction in Wegner's three-dimensional Ising lattice gauge theory (2019)

Motivated by the growing interest in self-correcting quantum memories, we study the feasibility of self-correction in classical lattice systems composed of bounded degrees of freedom with local interactions. We argue that self-correction, including a requirement of stability against external perturbation, cannot be realized in system with broken global symmetries such as the two-dimensional Ising model, but that systems with local, i.e., gauge symmetries, have the required properties. Previous work identified a three-dimensional (3D) quantum system which realizes a self-correcting classical memory [E. Dennis et al., J. Math. Phys. 43, 4452 (2002)]. Here, we show that a purely classical 3D system, Wegner's Ising lattice gauge model [F. J. Wegner, J. Math. Phys. 12, 2259 (1971)], can also realize this self-correction despite having an extensive ground-state degeneracy. We give a detailed numerical study to support the existence of a self-correcting phase in this system, even when the gauge symmetry is explicitly broken. More generally, our results obtained by studying the memory lifetime of the system are in quantitative agreement with the phase diagram obtained from conventional analysis of the system's specific heat [I. S. Tupitsyn et al., Phys. Rev. B 82, 085114 (2010)], except that self-correction extends beyond the topological phase, past the lower critical temperature.
Primary culture of rat thymic non-lymphoid cells: influence of culture time on the expression of macrophage differentiation antigens defined by monoclonal antibodies. (1991)

A panel monoclonal antibodies (mAbs) raised to rat thymic non-lymphoid cells has been shown to discriminate between distinct subpopulations of macrophages depending on their anatomic localization in the thymus. These reagents were used in this study to examine the expression of macrophage-associated antigens in primary culture of rat thymic stromal cells. The phenotype of both adherent macrophage (AM) monolayers and non-adherent cells (NAC) released in culture medium was studied at different time points after cultivation. More than 95% AM expressed ED1 and R-MC 38 antigens (pan-macrophage markers), class I MHC antigens (OX-18) and iC3b receptor recognized by OX-42 mAb. Most of them (70-85%) were reactive with ED2, R-MC 40, 41 and 42 mAbs specific for cortical and cortico-medullary zone (CMZ) macrophages. A much smaller percentage was positive with R-MC 43/44 and R-MC 46/47 mAbs staining CMZ/medullary macrophages and a subset of cortical macrophages, respectively. A minor subset of AM expressed class II MHC molecules which progressively decreased during cultivation. NAC were phenotypically heterogeneous. In comparison with adherent cells they contained a lower percentage of cortical/CMZ phenotype macrophages. In addition, NAC were slightly enriched in R-MC 43+ cells and more significantly expressed IA/E antigens (85-95%). ED3, R-MC 39 and 45 mAbs reactive with thymic macrophages in situ were mostly non-reactive with AM and NAC in culture.
ERROR PROBABILITY ANALYSIS (2003)

A summary is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Historiographical Imagination about Savagery and Barbaric Stages of Primitive Human Species (2021)

Indeed, Imagination could not work as a valid method for understanding prehistory and pre-historical processes as subjective or objective source. Yet historiographical imagination is only available inductive method for writing prehistory and pre-historical processes. Out of the few significant inherent natural features of the mind of Homo sapiens, a product of evolution memory, imagination, creativity, and power of comprehending complex natural processes are against preceding minds of primitive human species. The naturally evolved primitive human mind also learnt art of making fire, bow and arrows, pottery, stone implements, adobe-brick houses and later plantation by irrigation. The two historical facts transmuted the existing basic instincts making them primitive humans, other than preceding species of humans. 1) The phenomenon of inter-tribal battles, becoming order of the day during savagery because of sneaking clandestinely or openly, from other human tribes women, children, and domestic animals provided four kinds of human in a victorious tribe, “victor male”, “victor female”, “subjugated male” and “subjugated female”, which transfigured the existing sexual behavior in a tribe; and 2) the other phenomenon of “surplus labor” available only to males because of “surplus pregnancy” of females finally became the instigator of distinction between female and male, which in due course during the various stages of savagery and barbarism became susceptible for the origin of patriarchy. The present paper deals with the historiographical imagination as an inductive method for understanding responses of primitive human mind during various stages of savagery and barbarism.