gebhart/patrepeval huggingface dataset:
Nucleotide sequence analysis of a variant human T-cell leukemia virus (HTLV-Ib) provirus with a deletion in pX-I (1985)

A variant of human T-cell leukemia virus subgroup I (HTLV-I), designated HTLV-Ib, has been isolated from a transformed T-lymphocytic cell line established from a Zairian patient with adult T-cell lymphoma. A recombinant phage clone of the variant provirus, denoted lambda MC-1, hybridizes under high stringency to HTLV-I DNA probes, but 17 of 43 restriction enzyme sites differ from those of HTLV-I, 10 of them clustering within 1.5 kilobases in the env-pX region. Since this variant virus retains its capacity to transform T-cells in vitro, and since a pX product is suspected to be important in transformation, we have determined the nucleotide sequence of the entire pX region of this virus for comparison to the prototype HTLV-I. In addition, the region between the gag and pol genes, parts of the pol and env genes, and a portion of the U3 region of the long terminal repeat sequence were also analyzed. We noted 141 single-base-pair changes among 3,897 base pairs, which were relatively well distributed over those portions of the provirus that were examined. In addition, an 11-base-pair deletion was found which included the potential initiator ATG codon of the first open reading frame of pX (pX-I). The next potential initiator codon predicted by the sequence is followed by 10 codons and then a termination codon. An identical deletion was also demonstrated in the only provirus present in another cell line established from the same patient on a different occasion after transformation in vitro of normal human umbilical cord blood cells. These results indicate that pX-I is not required for transformation.
Face alignment via boosted ranking model (2008)

Face alignment seeks to deform a face model to match it with the features of the image of a face by optimizing an appropriate cost function. We propose a new face model that is aligned by maximizing a score function, which we learn from training data, and that we impose to be concave. We show that this problem can be reduced to learning a classifier that is able to say whether or not by switching from one alignment to a new one, the model is approaching the correct fitting. This relates to the ranking problem where a number of instances need to be ordered. For training the model, we propose to extend GentleBoost [23] to rank-learning. Extensive experimentation shows the superiority of this approach to other learning paradigms, and demonstrates that this model exceeds the alignment performance of the state-of-the-art.
Mass Spectrometry but Not Fluorimetry Distinguishes Affected and Pseudodeficiency Patients in Newborn Screening for Pompe Disease (2017)

The relatively large analytical range MS/MS GAA assay but not the fluorimetric assay in DBS provides a robust approach to reduce the number of referrals and should dramatically facilitate newborn screening of Pompe disease.
Development and Comparative Assessment of Hydrocolloid Based Against Wax Based Gastro Retentive Bilayered Floating Tablet Designs of Atorvastatin Calcium Using Qbd Approach (2015)

Development and Comparative Assessment of Hydrocolloid Based Against Wax Based Gastro Retentive Bilayered Floating Tablet Designs of Atorvastatin Calcium Using Qbd Approach Atorvastatin calcium is one of the most widely prescribed lipid lowering drug and due to its acidic degradation properties the bioavailability reported is only 12-14% when administered orally. The gastro retentive floating tablets of Atorvastatin calcium had shown enhanced bioavailability compared to conventional immediate release dosage forms. The study presented here was focused on comparing the physicochemical properties of two different bilayered controlled release gastro retentive buoyant formulation designs of Atorvastatin calcium tablets. The buoyancy layer for first formulation was swelling hydrocolloid based (HPMC) against the second formulation design which was non swellable wax (HCO) based. The drug release characteristics, kinetic models, buoyancy characteristics and stability were compared between the two formulation designs. Apart the DoE (22 factorial design) studies were carried out to understand the impact and range of release controlling agents in drug layer against the dissolution profile in pH 4.5 acetate buffer. The buoyancy properties were observed to be consistent and stable in case of HPMC based buoyancy system, where as the wax based formulation design had shown tendencies for layer seperation at higher agitation speeds.
GaN nanostructured p-i-n photodiodes (2008)

We report the fabrication of nanostructured p-i-n photodiodes based on GaN. Each device comprises arrays of ∼200nm diameter and 520nm tall nanopillars on a 1μm period, fabricated by e-beam lithography. Strong rectifying behavior was obtained with an average reverse current per nanopillar of 5fA at −5V. In contrast to conventional GaN diodes, nanostructured devices reproducibly show ideality factors lower than 2. Enhanced tunneling through sidewall surface states is proposed as the responsible mechanism for this behavior. Under backillumination, the quantum efficiency in nanostructured devices is partly limited by the collection efficiency of holes into the nanopillars.
1031: Comparison of Stage Migration Patterns Between North America and Europe: An Analysis of 11350 Men (2007)

You have accessJournal of UrologyPodium 33, Monday, May 21, 2007, 1:00 - 3:00 pm1 Apr 20071031: Comparison of Stage Migration Patterns Between North America and Europe: An Analysis of 11350 Men Andrea Gallina, Jochen Walz, Georg C. Hutterer, Shahrokh F. Shariat, Eric A. Klein, James A. Eastham, Luigi F. Da Pozzo, Alexandre De La Taille, Patrizio Rigatti, Markus Graefen, Hartwig Huland, Francesco Montorsi, Fred Saad, and Pierre I. Karakiewicz Andrea GallinaAndrea Gallina More articles by this author , Jochen WalzJochen Walz More articles by this author , Georg C. HuttererGeorg C. Hutterer More articles by this author , Shahrokh F. ShariatShahrokh F. Shariat More articles by this author , Eric A. KleinEric A. Klein More articles by this author , James A. EasthamJames A. Eastham More articles by this author , Luigi F. Da PozzoLuigi F. Da Pozzo More articles by this author , Alexandre De La TailleAlexandre De La Taille More articles by this author , Patrizio RigattiPatrizio Rigatti More articles by this author , Markus GraefenMarkus Graefen More articles by this author , Hartwig HulandHartwig Huland More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , Fred SaadFred Saad More articles by this author , and Pierre I. KarakiewiczPierre I. Karakiewicz More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)31259-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1031: Comparison of Stage Migration Patterns Between North America and Europe: An Analysis of 11350 Men." The Journal of Urology, 177(4S), p. 341 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 341 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Andrea Gallina More articles by this author Jochen Walz More articles by this author Georg C. Hutterer More articles by this author Shahrokh F. Shariat More articles by this author Eric A. Klein More articles by this author James A. Eastham More articles by this author Luigi F. Da Pozzo More articles by this author Alexandre De La Taille More articles by this author Patrizio Rigatti More articles by this author Markus Graefen More articles by this author Hartwig Huland More articles by this author Francesco Montorsi More articles by this author Fred Saad More articles by this author Pierre I. Karakiewicz More articles by this author Expand All Advertisement PDF downloadLoading ...
Cellular immunotherapy for ovarian cancer (2009)

Ovarian cancer is recognized as a paradigm for tumor-associated immune suppression. Innovative approaches for antagonism of tumor-associated regulatory T-cell infiltration and redirection of self antigen-driven regulatory T-cell activation may provide the key to development of future strategies for cellular immunotherapy against ovarian cancer.
Distortion of Interfaces in a Multilayer Polymer Co-extrusion Feedblock (2013)

Numerical simulations of co-extruded multilayered viscoelastic polymers flowing through a feed block were performed to analyze the effects of polymer rheology and process conditions on the distortion of interfaces between layers. Finite element simulations assuming Phan-Thien Tanner viscoelastic fluids were used to test the effects of increasing the number of layers introduced to the feed block and decreasing wall friction on interface distortion. It was found that increasing the number of layers introduced to the feed block decreased the overall distortion in the layers by reducing the overall magnitude of second normal stress differences and thus decreasing the normal in-plane velocities that cause distortion, which was validated by experiments. Decreasing wall friction was also found to decrease the amount of distortion in layer interfaces by decreasing the strength of these second normal stress differences.
Combined Endopeptidase Inhibition and Adrenomedullin in Sheep With Experimental Heart Failure (2002)

Adrenomedullin and the natriuretic peptides exert vasodilator, natriuretic, and aldosterone-inhibitory actions, making augmentation of both systems potential therapeutic strategies in heart failure. Adrenomedullin and an endopeptidase inhibitor (SCH32615) were administered separately and in combination in 8 sheep with heart failure. Compared with the control condition, SCH32615 (5 mg bolus+1 mg/kg per hour infusion for 3 hours) reduced arterial pressure, left atrial pressure, and peripheral resistance and increased cardiac output, urinary volume, sodium, creatinine, and cAMP excretion. Plasma atrial and brain natriuretic peptide and cGMP concentrations were increased, whereas aldosterone tended to fall. Adrenomedullin (50 ng/kg per minute infusion for 3 hours) induced directionally similar but significantly greater changes in all hemodynamic variables compared with SCH32615. Urinary cAMP, sodium, and creatinine excretion rose, whereas urinary volume was maintained. Circulating adrenomedullin, cAMP, renin, and angiotensin II levels were increased, aldosterone was reduced, and natriuretic peptide levels were unchanged. Coadministration of adrenomedullin and SCH32615 produced hemodynamic effects greater than those achieved during adrenomedullin administration alone. Despite the larger falls in blood pressure, renal function (urinary volume, sodium excretion, and creatinine clearance) was improved to a level similar to that during SCH32615 administration. Elevations in plasma adrenomedullin and cAMP were greater than those during adrenomedullin administration alone, whereas increments in natriuretic peptides were similar to those during SCH32615 alone. Plasma renin and angiotensin II were increased and aldosterone levels were reduced. In conclusion, cotreatment with adrenomedullin and an endopeptidase inhibitor has beneficial hemodynamic and renal effects in heart failure beyond those of either agent separately.
Preface (2008)

Wireless communications technologies have seen a remarkably fast evolution in the past two decades. Each new generation of wireless devices has brought notable improvements in terms of communication reliability, data rates, device sizes, battery life, and network connectivity. In addition, the increase homogenization of traffic transports using Internet Protocols is translating into network topologies that are less and less centralized. In recent years, ad-hoc and sensor networks have emerged with many new applications, where a source has to rely on the assistance from other nodes to forward or relay information to a desired destination.
4.1.11 METALLIC COATINGS ON DIELECTRIC SUBSTRATES (2004)

Metallic coatings are used in a broad variety of applications, for protective as weil as for decorative purposes (e.g. for sanitation, mirrors, gold coatings for jewelry etc.) and also as electric conductive layers for the manufacture ofprinted circuit boards. Depending on the kind of substrate different coating technologies have been developed. In the case of electric conductive or semi-conductive substrates the deposition of metals (Me) having a higher standard potential Meo/Mex+ than hydrogen H/H' can be performed by galvanic deposition. [n case of dielectric substrates (e.g. plastics, glasses, ceramics), coatings with metals like copper or nickel can be performed by lamination [1,2], by direct plating processes [3,4], by chemical (CYD) or physical (PYD) vapor deposition [5] as weil as by electroless metal deposition [6, 7].
Influence of radiation damage on perturbed angular distributions: The PoPbsystem (1981)

Perturbed angular distribution measurements in a Pb target have been performed for the $^{206,208,210}\mathrm{Po}$(${8}^{+}$) and $^{209}\mathrm{Po}$(${17/2}^{\ensuremath{-}}$) isomeric levels. Target temperatures were varied from 80 to 575 K and magnetic fields were applied from 0.1 to 6.1 T. The data can be explained with a combined strong magnetic and weak quadrupole interaction, with the quadrupole interaction arising from radiation damage in the host correlated in position with the implanted ion. A perturbation theory treatment of the combined magnetic and quadrupole interaction was developed and provides the basis for the interpretation of the results. The data are consistent with a Lorentzian distribution of electric field gradients centered around zero with half width $\frac{\ensuremath{\Gamma}}{2}=0.9\ifmmode\times\else\texttimes\fi{}{10}^{17}$ V/${\mathrm{cm}}^{2}$ at room temperature. At higher temperatures the gradients are weaker indicating that before the measurement begins at ${10}^{\ensuremath{-}8}$ sec after the implantation, some annealing of the initial damage takes place.NUCLEAR REACTIONS $^{204,206,207,208}\mathrm{Pb}(\ensuremath{\alpha},2n)^{206,208,209,210}\mathrm{Po}^{*}$, $E=24\ensuremath{-}25.5$ MeV. Enriched targets measured $\ensuremath{\sigma}({E}_{\ensuremath{\gamma}};\ensuremath{\theta},H,t,T)$ for isomeric levels. Deduced electric field gradients from radiation damage.
Impaired polyglutamylation of methotrexate as a cause of resistance in CCRF-CEM cells after short-term, high-dose treatment with this drug. (1988)

Two methotrexate-resistant sublines, CCRF-CEM R3/7 and CCRF-CEM R30/6, were selected from the human leukemia T-lymphoblast cell line, CCRF-CEM, after repeated exposures (7 and 6 times, respectively) for 24 h to constant concentrations (3 and 30 microM) of the drug. Analysis of the mechanism of resistance revealed no differences in levels of dihydrofolate reductase activity, its binding affinity for methotrexate, or in methotrexate transport between the CCRF-CEM parent and methotrexate-resistant cell lines. The development of resistance to methotrexate was associated with a marked decrease in the intracellular level of methotrexate polyglutamates. Although the resistant sublines were able to form substantial amounts of folate polyglutamates when measured with [3H]folic acid, the level of polyglutamates formed was decreased to about 50% of that formed by the parent cell line. No qualitative differences in folate polyglutamates formed were noted between the parental and resistant sublines. This is the first example of a cell line which displays resistance which is solely attributable to defective methotrexate polyglutamate synthesis.
Selective Targeting of a Novel Vasodilator to the Uterine Vasculature to Treat Impaired Uteroplacental Perfusion in Pregnancy (2017)

Fetal growth restriction (FGR) in pregnancy is commonly caused by impaired uteroplacental blood flow. Vasodilators enhance uteroplacental perfusion and fetal growth in humans and animal models; however, detrimental maternal and fetal side effects have been reported. We hypothesised that targeted uteroplacental delivery of a vasodilator would enhance drug efficacy and reduce the risks associated with drug administration in pregnancy. Phage screening identified novel peptides that selectively accumulated in the uteroplacental vasculature of pregnant mice. Following intravenous injection, the synthetic peptide CNKGLRNK selectively bound to the endothelium of the uterine spiral arteries and placental labyrinth <i>in vivo</i>; CNKGLRNK-decorated liposomes also selectively bound to these regions. The nitric oxide donor 2-[[4-[(nitrooxy)methyl]benzoyl]thio]-benzoic acid methyl ester (SE175) induced significant relaxation of mouse uterine arteries and human placental arteries <i>in vitro</i>; thus, SE175 was encapsulated into these targeted liposomes and administered to healthy pregnant C57BL/6J mice or endothelial nitric oxide synthase knockout (eNOS<sup>-/-</sup>) mice, which exhibit impaired uteroplacental blood flow and FGR. Liposomes containing SE175 (0.44mg/kg) or PBS were administered on embryonic (E) days 11.5, 13.5, 15.5 and 17.5; fetal and placental weights were recorded at term and compared to mice injected with free PBS or SE175. Targeted uteroplacental delivery of SE175 had no effect on fetal weight in C57BL/6J mice, but significantly increased fetal weight and mean spiral artery diameter, and decreased placental weight, indicative of improved placental efficiency, in eNOS<sup>-/-</sup> mice; free SE175 had no effect on fetal weight or spiral artery diameter. Targeted, but not free SE175 also significantly reduced placental expression of 4-hydroxynonenal, cyclooxygenase-1 and cyclooxygenase-2, indicating a reduction in placental oxidative stress. These data suggest that exploiting vascular targeting peptides to selectively deliver SE175 to the uteroplacental vasculature may represent a novel treatment for FGR resulting from impaired uteroplacental perfusion.
Osteopontin and periostin in bronchial tissue associate with a 20-year decline of pulmonary function in asthmatics (2014)

Rationale: Osteopontin and periostin are independently increased in asthmatic airways in response to Th2-driven inflammation and contribute to subepithelial fibrosis. Objectives: To determine whether the expression levels of osteopontin, periostin, or other factors are involved in the decline of long-standing pulmonary function by examining their expression in bronchial biopsy specimens collected at the time of initial evaluation in patients with asthma. Methods: Twenty asthmatics who underwent bronchoscopy between 1990 and 1995 participated in this study. Final evaluation follow-up was done in 2012. Using biopsy samples, immunohistochemistry including osteopontin-expressing cells and deposition of periostin were evaluated. Associations of annual change in forced expiratory volume in one second (ΔFEV 1 ) with histological or clinical indices were analyzed. Measurements and Results: Median follow-up period was 20.3 (SD 1.3) years after bronchial biopsy, and the average ΔFEV 1 was -19.1 (SD 30.8) mL/year. The numbers of osteopontin-positive cells (p = 0.004), CD8 T-lymphocytes (p = 0.01), and eosinophils (p = 0.04), and the amount of periostin deposition (p = 0.001) in bronchial subepithelium were associated with ΔFEV 1 . Multivariate stepwise analysis revealed that both osteopontin (p = 0.04) and periostin (p = 0.0497) independently affected ΔFEV 1 . Expression levels of osteopontin and periostin were related to the number of eosinophils (p = 0.04 and p = 0.047) and the expression of α smooth muscle actin (p = 0.01 and p = 0.0002). Conclusion: Increased expression levels of these proteins in asthmatic airways was related to an accelerated decline in FEV 1 over a long-term period.
Development of Consensus-Based Best Practice Guidelines for Postoperative Care Following Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis (2016)

5.
Therapie des Postvagotomie-Syndroms (1976)

Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Efficiency improvement in the spline-type divided-difference interpolation technique for impedance matrix calculation (1999)

In this letter, a method to determine the sampling intervals for the spline-type divided-difference interpolation of spectral integrals is suggested by utilizing simple differentiation of the interpolating function. It improves the numerical efficiency of the recent research based on the spline-type divided-difference interpolation scheme. The proposed method is applied to analyze the characteristics of an aperture-coupled patch antenna. Numerical results obtained by using this approach are in good agreement with those of other approaches. ©1999 John Wiley & Sons, Inc. Microwave Opt Technol Lett 23: 361–363, 1999.
Single-electron memory using carrier traps in a silicon nitride layer (1999)

A single-electron memory that utilizes carrier traps in a silicon nitride layer is proposed and experimentally demonstrated. The proposed device consists of an insulating three-layered memory node structure formed on a silicon substrate and a highly sensitive aluminum single-electron transistor that detects the written information. Successful memory operation is demonstrated with two types of write modes (slow/rapid) that depend on the state of the Si channel underneath. Carrier retention time is estimated to be around 45 min. Possibilities for both destructive and nondestructive readout are discussed.
Transfer Learning Based Adaptive Automated Negotiating Agent Framework (2022)

With the availability of domain specific historical negotiation data, the practical applications of machine learning techniques can prove to be increasingly effective in the field of automated negotiation. Yet a large portion of the literature focuses on domain independent negotiation and thus passes the possibility of leveraging any domain specific insights from historical data. Moreover, during sequential negotiation, utility functions may alter due to various reasons including market demand, partner agreements, weather conditions, etc. This poses a unique set of challenges and one can easily infer that one strategy that fits all is rather impossible in such scenarios. In this work, we present a simple yet effective method of learning an end-to-end negotiation strategy from historical negotiation data. Next, we show that transfer learning based solutions are effective in designing adaptive strategies when underlying utility functions of agents change. Additionally, we also propose an online method of detecting and measuring such changes in the utility functions. Combining all three contributions we propose an adaptive automated negotiating agent framework that enables the automatic creation of transfer learning based negotiating agents capable of adapting to changes in utility functions. Finally, we present the results of an agent generated using our framework in different ANAC domains with 100 different utility functions each and show that our agent outperforms the benchmark score by domain independent agents by 6%.