gebhart/patrepeval huggingface dataset:
Molecular characterization of Streptococcus suis strains by 16S-23S intergenic spacer polymerase chain reaction and restriction fragment length polymorphism analysis. (2006)

We developed a new molecular method of typing Streptococcus suis based on polymerase chain reaction (PCR) amplification of a large fragment of rRNA genes, including a part of the 16S and 23S genes and the 16S-23S intergenic spacer region (ISR), followed by restriction fragment length polymorphism (RFLP) analysis with RsaI or MboII endonuclease. The 16S-23S ISRs of 5 S. suis isolates were sequenced and compared. Size and sequence polymorphisms were observed between the S735 reference strain and the 4 wild-type strains. The genetic relationships between 138 independent S. suis strains belonging to various serotypes, isolated from swine or human cases, were determined. The discriminatory power of the method was > 0.95, the threshold value for interpreting typing results with confidence (0.954 with RsaI and 0.984 with RsaI plus MboII). The in vitro reproducibility was 100%. The strains isolated from humans were less genetically diverse than the strains isolated from pigs. For the first time, 2 molecular patterns (R6, M9) were significantly associated with S. suis serotype 2 strains. This genetic tool could be valuable in distinguishing individual isolates of S. suis during epidemiologic investigations.
Supplementary Table S3 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer (2023)

&lt;p&gt;miRNA differentially expressed in metastatic ARCaPM prostate cancer cells and non-metastatic ARCaPE prostate cancer cells by multiplexed real time PCR analysis. miRNA in bold are in the DLK1-DIO3 mega-cluster.&lt;/p&gt;
MicroRNAs: Processing, Maturation, Target Recognition and Regulatory Functions. (2011)

The remarkable discovery of small noncoding microRNAs (miRNAs) and their role in posttranscriptional gene regulation have revealed another fine-tuning step in the expression of genetic information. A large number of cellular pathways, which act in organismal development and are important in health and disease, appear to be modulated by miRNAs. At the molecular level, miRNAs restrain the production of proteins by affecting the stability of their target mRNA and/or by down-regulating their translation. This review attempts to offer a snapshot of aspects of miRNA coding, processing, target recognition and function in animals. Our goal here is to provide the readers with a thought-provoking and mechanistic introduction to the miRNA world rather than with a detailed encyclopedia.
Supplementary Video 5 from Cell Surface Delivery of TRAIL Strongly Augments the Tumoricidal Activity of T Cells (2023)

&lt;p&gt;WMV file - 1250K&lt;/p&gt;
Acceptability of a Long-Acting, Multipurpose Vaginal Ring: Findings from a Phase I Trial in the U.S. and Dominican Republic (2022)

<b><i>Background:</i></b> Women worldwide face risks from pregnancy, HIV, and other sexually transmitted infections (STIs). To date, highly effective contraceptive methods provide no HIV/STI protection, and HIV prevention products, excluding condoms, provide no pregnancy protection. Intravaginal rings (IVRs) delivering antiretrovirals and contraceptives are a promising multipurpose prevention technology (MPT). <b><i>Methods:</i></b> Embedded within a Phase I randomized, placebo-controlled trial, we examined acceptability of continuous versus interrupted use of a 90-day MPT IVR among 47 low-risk women in Norfolk, Virginia and the Dominican Republic. A baseline survey assessed menstruation attitudes, risk perceptions and trial-related motivations. Follow-up surveys (M1/M3) examined user experiences with and preferences for IVR attributes; 18 women also participated in two in-depth interviews. <b><i>Results:</i></b> Most women rated the IVR's flexibility and smoothness (86%) and ease of insertion/removal (76%) as very acceptable. Fewer women similarly rated the IVR size (57%) and changes in color from menstruation (52%). Most participants experienced no changes or less bleeding. Those reporting more/heavier bleeding (20% M1, 15% M3) disliked the change. Overall, women preferred a 3-month (75%) to a 1-month IVR (7.5%) or a bimonthly injectable (10%). In qualitative interviews, women were willing to continuously use an IVR for 6-12 months, providing it did not "<i>degrade</i>" inside the body. Reasons for trial participation and prevention preferences, menstrual attitudes, and perceived IVR benefits and doubts varied by site. <b><i>Conclusions:</i></b> Findings provide strong evidence of demand for an MPT IVR that protects from pregnancy and HIV/STIs, lasts longer than 1 month, minimally disrupts menstrual bleeding, and is in women's control. numberClinicalTrials.gov: #NCT03279120.
Design of aromatic copolyesters for use in microelectronic devices (1996)

Abstract The next generation of microelectronic devices will require design of new kinds of polymers which are tailored to display a dielectric constant as low as 2.0, a coefficient of thermal expansion (CTE) which matches the metal circuitry as well as the silicon substrate, moisture and chemical resistance, and dimensional stability at processing temperatures of 300‐400°C which are required to form an adhesive bond between laminates. In our program, we have made significant progress in all of these areas through the use of liquid crystalline copolyesters (LCP's) laminated with a newly developed crosslinkable copolyester. In this paper, data are presented which illustrate how films and coatings of either system can be made to adhere in the solid state by interchain transesterification reactions (ITR) at the interface. Ability to foam the crosslinkable copolyester films provides direct control over the dielectric constant. The effect of pore size and distribution on the dielectric constant will be discussed. The potential to dramatically increase the melting point of the LCP's through high temperature annealing is also discussed.
A novel constrained, paclitaxel-coated angioplasty balloon catheter (2017)

The study aimed to assess drug adherence, transfer to the vessel wall, tolerance and efficacy of a constrained angioplasty balloon coated with an excipient-enhanced paclitaxel coating (Chocolate coated balloon [CCB]) in the porcine model.Drug adherence was investigated in vitro. Drug transfer was evaluated in porcine arteries. A stent overstretch model was chosen to provoke intimal thickening in the efficacy and tolerance study. Conventional uncoated balloons were used as controls. CCB were coated with a nominal (3 µg/mm2) and high dose (two completely overlapping inflations each at 6 µg/mm2) of paclitaxel. Efficacy was assessed by histomorphometry and quantitative coronary angiography (QCA). Tolerance, including potential downstream effects, was assessed by myocardial function and histopathology. The CCB lost 6±12% of dose during in vitro simulated delivery to the lesion; drug transfer to the vessel wall was 14±4%. QCA and histomorphometry revealed no baseline differences between treatment groups. Thirty days after treatment, both doses of the CCB resulted in a 50% reduction in neointimal thickening of arteries relative to the uncoated balloon group. Maximum neointimal thickness was 1.12±0.36 mm for uncoated control specimens and 0.46±0.06 mm and 0.44±0.30 mm for the two CCB doses (3 and 2×6 µg/mm2), respectively. There were no device-related animal deaths or changes in left ventricular ejection fraction or device-specific myocardial histopathologies. There were no statistically significant differences between inflammatory scores among treatment groups.The results demonstrate efficacy and tolerance of a mechanically unique constrained angioplasty balloon within the tested dose range of the selected paclitaxel coating in the chosen porcine preclinical model.
A public key encryption scheme secure against key dependent chosen plaintext and adaptive chosen ciphertext attacks. (2008)

Recently, at Crypto 2008, Boneh, Halevi, Hamburg, and Ostrovsky (BHHO) solved the longstanding open problem of “circular encryption,” by presenting a public key encryption scheme and proving that it is semantically secure against key dependent chosen plaintext attack (KDMCPA security) under standard assumptions (and without resorting to random oracles). However, they left as an open problem that of designing an encryption scheme that simultaneously provides security against both key dependent chosen plaintext and adaptive chosen ciphertext attack (KDM-CCA2 security). In this paper, we solve this problem. First, we show that by applying the Naor-Yung “double encryption” paradigm, one can combine any KDM-CPA secure scheme with any (ordinary) CCA2 secure scheme, along with an appropriate non-interactive zero-knowledge proof, to obtain a KDM-CCA2 secure scheme. Second, we give a concrete instantiation that makes use the above KDM-CPA secure scheme of BHHO, along with a generalization of the Cramer-Shoup CCA2 secure encryption scheme, and recently developed pairing-based NIZK proof systems. This instantiation increases the complexity of the BHHO scheme by just a small constant factor.
CrkL Activates Integrin-Mediated Hematopoietic Cell Adhesion Through the Guanine Nucleotide Exchange Factor C3G (1999)

CrkL is a member of the Crk family of adapter proteins consisting mostly of SH2 and SH3 domains. CrkL is most abundantly expressed in hematopoietic cells and has been implicated in pathogenesis of chronic myelogenous leukemia. However, its function has not been precisely defined. Here, we show that overexpression of CrkL enhances the adhesion of hematopoietic 32D cells to fibronectin. The CrkL-induced increase in cell adhesion was blocked by antibodies against VLA-4 (4β1) and VLA-5 (5β1) but was observed without changes in surface expression levels of these integrins. Studies using CrkL mutants demonstrated that the SH2 domain is partially required for enhancing cell adhesion, whereas the C-terminal SH3 domain as well as the tyrosine phosphorylation site (Y207) is dispensable. In contrast, the N-terminal SH3 domain, involved in binding C3G and other signaling molecules, was showed to play a crucial role, because a mutant defective of this domain showed an inhibitory effect on the cell adhesion to fibronectin. Furthermore, overexpression of C3G also increased the adhesion of hematopoietic cells to fibronectin, whereas a C3G mutant lacking the guanine nucleotide exchange domain abrogated the CrkL-induced increase in cell adhesion. On the other hand, a dominant negative mutant of H-Ras or that of Raf-1 enhanced the basal and CrkL-induced cell adhesion and that of R-Ras modestly decreased the adhesion. Taken together, these results indicate that the CrkL-C3G complex activates VLA-4 and VLA-5 in hematopoietic cells, possibly by activating the small GTP binding proteins, including R-Ras, through the guanine nucleotide exchange activity of C3G.
Performance of rotational speed controlled small-scale head-dependent hydroelectric power plant (2008)

Small scale or micro scale hydroelectric power production is characterized by high investment costs compared to operation costs. In addition, the repayment time is often long, more than ten years (if not subsidized heavily) which requires that a small-scale hydropower plants can be profitable only if both the investment costs and the running costs are low. The performance and efficiency of a plant is very important because having long repayment time means that the efficiency improvement of one percentage unit often means the ten percentage unit improvement in profit. The most economical way to control the flow is sometimes a two point control where generators are switched on and off depending on high water level used as control variable. The water level cannot be kept constant using this method, but the traditionally used mechanical blade angle adjustment system is too expensive in very small (approximately <100 kW) units. The new method of controlling the upper water level (head) is the use of rotational speed control of turbine, implemented by a four quadrant frequency converter. The efficiency of a 4-quadrant frequency converter is approximately 97 %, which reduces the income compared to the situation where the generators are directly connected to electricity network. However, when the head is kept constant using a frequency converter, it is not required to switch off the generator circuit breakers which have a finite life t im e a n d th e h e a d h e ig h t c a n b e k e p t o p ti m a l in t e r m s o f performance. In this paper, a system structure, a pilot plant installation and example calculations on the feasibility of a frequency converter driven fixed blade hydro power turbine is given.
Effect of hydrogen incorporation on sub-gap density of states in amorphous InGaZnO thin-film transistors (2020)

Amorphous semiconducting transparent oxides like InGaZnO<sub>4</sub> (a-IGZO) have a broad distribution of metal and oxygen vacancy defects that determine thin film transistor (TFT) characteristics and impact device reliability metrics such as hysteresis. Here, we demonstrate how hydrogen modifies the density of states (DoS) through a novel on-chip method that spectrally resolves trap concentration in a-IGZO spanning the bandgap. Requiring laser energies continuously tunable from 0:26 to 3:1 eV, this method also employs difference frequency generation to access shallow states near the conduction band. We characterize the effect of hydrogen incorporation on the sub-gap peaks of the DoS of an a-IGZO TFT. Specifically, our data suggests hydrogen hybridizes with vacancy defects through metal-hydrogen (M-H) bonds that passivate oxygen vacancy sites and O-H bonds that passivate metal vacancy sites. These interactions result in a suppression of oxygen vacancy and metal vacancy- related trap states in the sub-gap and an enhancement of a metal-hydrogen bonding peak near the VBM. Temperature dependent, photon energy-dependent hysteresis, and transient defect lifetime measurements further reveal the strong impact of hydrogen concentration on a-IGZO TFT performance germane to current optical display technology.
Elements of Signal Theory (2002)

This chapter contains sections titled: Signal Space Discrete Signal Representation Continuous-time Linear Systems Discrete-time Linear Systems Signal Bandwidth Passband Signals Second-order Analysis of Random Processes The Autocorrelation Matrix Examples of Random Processes Matched Filter Ergodic Random Processes Parametric Models of Random Processes Guide to the Bibliography Bibliography Appendix 1.A: Multirate Systems Appendix 1.B: Generation of Gaussian Noise
Second Prize: Forced versus Minimal Intravenous Hydration in the Management of Acute Renal Colic: A Randomized Trial (2006)

Treatment of uncomplicated renal colic has traditionally included vigorous intravenous hydration, as well as medications for the control of pain and nausea. Our data suggest that maintenance intravenous fluids are as efficacious as forced hydration with regard to patient pain perception and narcotic use. Moreover, it appears the state of hydration has little impact on stone passage.
Insulin-like growth factor-1 and myocyte growth: the danger of a dogma. Part I. Postnatal myocardial development: normal growth (1996)

The possibility that the human heart may respond to an increase in pressure and volume loads not only by hypertrophy of pre-existing myocytes but also by myocyte cellular hyperplasia has been a matter of controversy for several decades. The critical heart weight theory introduced by Linzbach in the late 1940s and early 1950s [l] has suggested that in the presence of a cardiac weight of nearly 500 g or greater, hyperplasia of myofibers begins and this cellular process constitutes the prevailing form of myocyte growth in the heart. These initial findings were restricted to the left ventricle, but similar adaptations subsequently have been shown at the level of the right ventricle [2], indicating that the entire heart may react to a sustained increase in workload by the generation of new myocytes through mitotic division of the stressed muscle cells. In contrast, experimental studies have demonstrated that short-term cardiac hypertrophy in the adult heart results from an enlargement of myocytes with little DNA synthesis in myocyte nuclei, possibly representing the formation of polyploid cells [3-51. Thus, it has become a general belief that no proliferation of myocytes occurs once cell division has ceased immediately after birth in the mammalian myocardium. These studies in the pressure-overloaded rat heart have examined thymidine incorporation early after the imposition of the overload and the lack of autoradiographic labeling in myocytes has been interpreted as a definitive indication of the terminally differentiated
Tilting in UCA-Based LoS MIMO Systems (2023)

We consider a <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$4 \times 4$ </tex-math></inline-formula> line-of-sight multiple-input multiple-output (LoS MIMO) system with uniform circular arrays (UCAs) at the transmitter (Tx) and receiver (Rx). First, we show that the optimum design of non-tilted UCAs of four antennas can be generalized to the design of optimum elliptical arrays (EAs). Afterwards, we investigate the effect of tilting the Tx or Rx UCA over different transmit distances. Although it is commonly considered that tilting a UCA at a fixed transmit distance is detrimental, we show that a tilted UCA can be optimum, in terms of capacity, at other transmit distances. We showcase that this can be explained based on the optimum design of EAs of four antennas. Specifically, we provide a valid approximation for the optimum transmit distance when a UCA is tilted by a given angle or, equivalently, for the optimum tilting angle of a UCA at a certain transmit distance. The use of the approximations is validated with simulations, also for the design of UCAs with more than 4 antennas.
Abstract DDT01-01: PT2385: First-in-class HIF-2α antagonist for the treatment of renal cell carcinoma (2015)

Abstract Hypoxia-inducible factors (HIFs), including HIF-1α and HIF-2α, are transcription factors that mediate cellular response to changes of oxygen supply. These proteins become stabilized under hypoxia and subsequently activate the expression of genes to facilitate cell survival and proliferation. HIF proteins are activated in many types of cancers due to the tumor hypoxic microenvironment and have been implicated in cancer initiation, progression and metastasis. The oncogenic role of HIF-2α is pertinent in clear cell renal carcinoma (ccRCC). In the majority of ccRCC tumors, the von Hippel-Lindau protein (VHL) that targets HIF-2α for degradation is inactivated, leading to the accumulation of HIF-2α and the activation of genes that drive kidney cancer tumorigenesis. We have identified small molecules that bind to the PAS-B domain of HIF-2α protein and block it's dimerization with ARNT (aryl hydrocarbon receptor nuclear translocator, HIF-1β), a prerequisite for its transcriptional activities. Specifically, we describe PT2385, a selective, orally active HIF-2α antagonist with potent anti-cancer activity in mouse models of ccRCC. PT2385 is currently under evaluation in Phase I clinical trials for the treatment of ccRCC. Citation Format: Eli M. Wallace, Zhaodan Cao, Tzuling Cheng, Robert Czerwinski, Darryl D. Dixon, Xinlin Du, Barry Goggin, Jonas Grina, Megan Halfmann, Guangzhou Han, Heli Huang, John A. Josey, Melissa A. Maddie, Sarah Olive, James Rizzi, Stephen T. Schlachter, Hui-Ling Tan, Bin Wang, Keshi Wang, Paul M. Wehn, Shanhai Xie, Rui Xu, Hanbiao Yang. PT2385: First-in-class HIF-2α antagonist for the treatment of renal cell carcinoma. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr DDT01-01. doi:10.1158/1538-7445.AM2015-DDT01-01
Feasibility of a short message service (SMS) intervention to deliver tuberculosis testing results in peri-urban and rural Uganda (2019)

Reporting Xpert results via automated SMS is technically feasible and results in approximately half of patients receiving their test results immediately. Additional research should be done to address process inefficiencies in order to maximize impact of this technology and link its successful utilization to improved patient outcomes.
ChemInform Abstract: Synthesis and Evaluation of the Antiviral Activity of Acyclic Nucleosides Carrying Fluorine and Sulfur Substituents. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Interferon Resistance in Leukaemic Cells and Lysosome Stability (1977)

Conference Article| August 01 1977 Interferon Resistance in Leukaemic Cells and Lysosome Stability JOHN WÉRENNE; JOHN WÉRENNE 1International Institute of Cellular and Molecular Pathology, UCL 7529, Avenue Hippocrate 75, B-1200 Brussels, Belgium Search for other works by this author on: This Site PubMed Google Scholar JACQUES BARTHOLEYNS JACQUES BARTHOLEYNS 2International Institute of Cellular and Molecular Pathology, UCL 7529, Avenue Hippocrate 75, B-1200 Brussels, Belgium Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1977 Biochemical Society1977 Biochem Soc Trans (1977) 5 (4): 1176–1178. https://doi.org/10.1042/bst0051176 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation JOHN WÉRENNE, JACQUES BARTHOLEYNS; Interferon Resistance in Leukaemic Cells and Lysosome Stability. Biochem Soc Trans 1 August 1977; 5 (4): 1176–1178. doi: https://doi.org/10.1042/bst0051176 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1977 Biochemical Society1977 Article PDF first page preview Close Modal You do not currently have access to this content.
Proposal of Organ Pressure Regulation by Mechanical Stimulation for Functional Recovery (2017)

A major cause in intensity myopia is the extension of the eye itself. When the eyeball is deformed, tensile stress is generated in the fundus, which causes a large load on the retina and the like, leading to blindness. Although eyeglasses, contact lenses, LASIK, etc. are present as countermeasures against myopia, it is not possible to treat deformation of the eyeball itself. In this study, to improve deformation, we devised a method to cure deformation by applying force from the back of the eyeball. In the experiment, a treatment device was made and the eyeball was compressed from the back. After that, we successfully observed the fundus at the time of non-compression and compression. It was confirmed that the retina was wrinkled along the blood vessel in the ocular fundus at the time of compression. In the future it is necessary to adjust the force to control and prevent wrinkles.