gebhart/patrepeval huggingface dataset:
Electrical Properties of Low-$V_{T}$ Metal-Gated n-MOSFETs Using $\hbox{La}_{2}\hbox{O}_{3}/\hbox{SiO}_{x}$ as Interfacial Layer Between HfLaO High-$\kappa$ Dielectrics and Si Channel (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> In this letter, we report that by employing the <formula formulatype="inline"> <tex>$\hbox{La}_{2}\hbox{O}_{3}/ \hbox{SiO}_{x}$</tex></formula> interfacial layer between HfLaO <formula formulatype="inline"><tex>$(\hbox{La} = \hbox{10}\%)$</tex> </formula> high-<formula formulatype="inline"><tex>$\kappa$</tex></formula> and Si channel, the <formula formulatype="inline"><tex>$\hbox{Ta}_{2}\hbox{C}$</tex> </formula> metal-gated n-MOSFETs <formula formulatype="inline"><tex>$V_{T}$</tex> </formula> can be significantly reduced by <formula formulatype="inline"> <tex>$\sim$</tex></formula>350 mV to 0.2 V, satisfying the low- <formula formulatype="inline"> <tex>$V_{T}$</tex></formula> device requirement. The resultant n-MOSFETs also exhibit an ultrathin equivalent oxide thickness (<formula formulatype="inline"> <tex>$\sim$</tex></formula>1.18 nm) with a low gate leakage (<formula formulatype="inline"> <tex>$J_{G} = \hbox{10}\ \hbox{mA/cm}^{2}$</tex></formula> at 1.1 V), good drive performance (<formula formulatype="inline"><tex>$I_{\rm on} = \hbox{900}\ \mu\hbox{A}/\mu\hbox{m}$ </tex></formula> at <formula formulatype="inline"> <tex>$I_{\rm soff} = \hbox{70}\ \hbox{nA}/\mu\hbox{m}$</tex></formula>), and acceptable positive-bias-temperature-instability reliability. </para>
Overexpression of the Zinc Uptake Transporter hZIP1 Inhibits Nuclear Factor-κB and Reduces the Malignant Potential of Prostate Cancer CellsIn vitroandIn vivo (2008)

Our results show that hZIP1 overexpression has a functional effect on the malignant potential of prostate cancer cells via inhibition of NF-kappaB-dependent pathways and support the concept that hZIP1 may function as a tumor suppressor gene in prostate cancer.
Management of insulin‐treated diabetes in Tasmania (1999)

Some aspects of diabetes self-care and medical care have improved in Tasmania since the 1984 survey (eg, frequency of self-monitoring of blood glucose rose from 50% to 98%). However, our findings suggest that further improvements are needed to increase daily self-monitoring of blood glucose, attendance at diabetes educator and dietitian services, and foot examinations by doctors. Additional efforts are also needed to lower the prevalence of smoking.
Modification of ribosomal RNA by ribosome-inactivating proteins from plants (1988)

Footprinting experiments for DNase I digests of a 139-base-pair segment of pBR-322 DNA in the presence of either netropsin or actinomycin D were carried out. Plots of oligonucleotide concentration as a function of drug concentration were analyzed to study the enhancement in cleavage rates at approximately 30 sites, accompanying drug binding at other sites. The pattern of enhancements is not consistent with drug-induced DNA structural changes, but agrees with a redistribution mechanism involving DNase I. Since the total number of enzyme molecules per fragment remains unchanged, drug binding at some sites increases the enzyme concentration at other sites, giving rise to increased cleavage. The consequences of the redistribution mechanism for analysis of footprinting experiments are indicated.
P3-18-06: AEZS-131 – A Highly Selective ERK-Inhibitor: Characterization and Preclinical Testing in Triple Negative Breast Cancer (TNBC). (2011)

Abstract Introduction: Overexpression of MAPK has been detected in 34 % of TNBC and has been found to be associated with anthracycline resistance (1). AEZS-131 is a highly selective orally active ERK1/2-inhibitor, which has shown in vivo activity (first in class) in colon cancer. The following study explores mode of action and efficacy in models of TNBC. Study design: AEZS-131 was tested in a kinase panel of 36 STK, 26 TK and 7 PIK to check for selectivity. Inhbition of Rsk-phosphorylation (cellular substrate of ERK) was evaluated by western blot analysis. Mode of action was explored by cell cycle FACS-analysis. Cleavage of PARP was explored by Western blot. Cytotoxic efficacy was evaluated in 5 TNBC, of which 2 had mutations in the MAPK signal transduction pathway lines, by MTT assay. Additionally it was explored if inhibition of classical apoptosis could abrogate the effect of AEZS-131. Results: AEZS-131 selectively inhibited ERK with an IC50&amp;lt;4nM. Phosphorylation of Rsk-1 the cellular substrate of ERK was inhibited with an IC 50 of 158 nM. AEZS-131 induced cell cycle arrest in G1 dose-dependently and cleavage of PARP. EC 50 was 0,739 μM for MDA-MB-231 (Ras-mutated), 0,137 μM for MDA-MB-435s (B-RAF mutated), 17,5 μM for MDA-MB-468 (PTEN loss), 25 μM for HCC 1806. HCC 1937 were not inhibited by the compound. Of note, inhibition of classical apoptosis did not alter the cytotoxic effect of the compound in MDA-MB-468 and HCC-1806 cells. Conclusions: AZS-131 was shown to selectively inhibit ERK at low nM concentrations and to induce G1-arrest. Accordingly, the cytotoxic effect most pronounced in TNBC cell lines with mutations in the MAPK pathway. If classical apoptosis is inhibited, cytotoxic effects remain unchanged, suggesting that AEZS-131 can also induce nonclassical forms of programmed cell death. AEZS-131 should be further explored in TNBCs with overexpression of MAPK or mutations in the MAPK-pathway. *Æterna Zentaris GmbH, Frankfurt/M, Germany. (1): MAPK overexpression is associated with anthracycline resistance and increased risk for recurrence in patients with triple-negative breast cancer. Eralp Y, Derin D, Ozluk Y, Yavuz E, Guney N, Saip P, Muslumanoglu M, Igci A, Kücücük S, Dincer M, Aydiner A, Topuz E. Ann Oncol. 2008 Apr;19(4):669–74. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P3-18-06.
Pico Satellite Solar Cell Testbed (PSSC Testbed) Design (2007)

Abstract : The PSSC Testbed flight experiment is designed to obtain accelerated space environment degradation data for advanced solar cells. The acceleration factor, with respect to total dose radiation for operational missions, will be obtained by flying the PSSC Testbed in a Geosynchronous Transfer Orbit (GTO). The resulting data will provide DOD and commercial users of advanced solar cells insight into the actual performance of these solar cells before they are flown as the power supply of a multimillion dollar satellite.
Removal of benzene, MTBE and toluene from contaminated waters using biochar-based liquid activated carbon (2022)

Fuel components such as benzene, toluene, and methyl tertiary-butyl ether (MTBE) are frequently detected pollutants in groundwater resources. Ex-situ remediation technologies by activated carbon have been used for treatment for many years. However, due to high cost of these technology, more attention has been given to the in-situ remediation methods of contaminated groundwaters using liquid carbon adsorbents. Literature search showed limited studies on using adsorbents in liquid form for the removal of such contaminants. Therefore, this lab-scale study investigates the capacity of using raw biochar-based liquid activated carbon and iron-modified biochar-based liquid activated carbon to remove these pollutants. The adsorption efficiency of the synthesized liquid activated carbon and iron-modified liquid activated carbon mixed with sand, limestone, and 1:1 mixture of sand/limestone, was tested using batch suspension experiments. Adsorption by granular activated carbon was also investigated for comparison with liquid activated carbon. Results of the study revealed that mixing of liquid activated carbon or LAC-Fe on subsurface materials had not improved the removal efficiency of MTBE. At the same time, it showed a slight improvement in the adsorption efficiency of benzene and toluene. In all cases, the removal by GAC was higher with around 80% and 90% for MTBE and BT, respectively. Results also showed that benzene and toluene were better removed by liquid activated carbon and iron-modified liquid activated carbon (∼ 40%) than MTBE (∼ 20%). It is also found that water chemistry (i.e., salinity and pH) had insignificant effects on the removal efficiency of pollutants under the study conditions. It can be concluded that more research is needed to improve the capacity of biochar-based liquid-activated carbon in removing MTBE, benzene and toluene compounds that will lead to improve the utilization of liquid activated carbon for the in-situ remediation of contaminated groundwaters.
SChISM: Scalable Cache Incoherent Shared Memory (2008)

This paper motivates and describes a class of accelerator architectures that manage cache coherence in soft-ware to exploit data sharing and communication characteristics present in emerging highly parallel workloads. Based on previous findings and our own studies, we show that our target applications have structure to their com-munication patterns that can be leveraged to move most cache coherence management into software. Replacing hardware cache coherence with software mechanisms allows die area to be reclaimed for more compute resources while also reducing hardware design complexity. Moreover, there is a prevalent programming style for large-scale parallel computation which can be mapped into a low-level task-based programming model that manages coherence in software without sacrificing usability and performance. We also observe that the main benefit of hardware cache coherent systems is not for supporting data-parallel applications, but rather for implementing preemptive multitasking operating systems where migratory data and global locking constructs must be supported efficiently. To support the system software features that are re-quired for applications running on an accelerator platform, we demonstrate an implementation of the Rigel Task Model. The Rigel Task Model is a low-level programming model that performs work distribution, task scheduling, software-enforced cache coherence, and synchronization in software, with limited specialized hardware, for an accelerator architecture without hardware cache coherence. 1
Limited capacity of the nuclear matrix to bind telomere repeat binding factor TRF1 may restrict the proliferation of mortal human fibroblasts (2003)

The maintenance of telomere integrity is essential for prolonged cell proliferation, and failure in this mechanism is a most consistent manifestation of cellular senescence. In this study, we investigated the role of telomere repeat binding factor (TRF1) in the proliferation of human fibroblasts. TRF1 expression is upregulated in a large variety of immortal human cells and supports de novo telomere formation in a dose-dependent manner. These observations suggest that the suppression of TRF1 might limit telomere maintenance and thus the life span of mortal cells. However, primary fibroblasts ectopically overexpressing TRF1 were unable to avoid senescence. On the other hand, exogenously expressed TRF1 in primary fibroblasts neither supported de novo telomere formation nor bound to the nuclear matrix as tightly as observed in immortal cells that show upregulated TRF1 expression. We present evidence suggesting that mortal human cells lack specific ligand(s) that anchor TRF1 to the nuclear matrix and that this contributes to their limited lifespan.
Cell-Based Therapies for Cardiac Repair: A Meeting Report on Scientific Observations and European Regulatory Viewpoints (2015)

In the past decade, novel cell-based products have been studied in patients with acute and chronic cardiac disease to assess whether these therapies are efficacious in improving heart function and preventing the development of end-stage heart failure. Cardiac indications studied include acute myocardial infarction (AMI), refractory angina, and chronic heart failure (CHF). Increased clinical activity, experience, and multiple challenges faced by developers have been recognized at the regulatory level. In May 2014, the Committee for Advanced Therapies (CAT) discussed in an expert meeting various cell-based medicinal products developed for cardiac repair, with a focus on non-manipulated bone marrow cells, sorted bone marrow or apheresis, and expanded cells, applied to patients with AMI or CHF. The intention was to share information, both scientific and regulatory, and to examine the challenges and opportunities in this field. These aspects were considered from the quality, and non-clinical and clinical perspectives, including current imaging techniques, with a focus on AMI and CHF. The scope of this overview is to present the European regulatory viewpoint on cell-based therapies for cardiac repair in the context of scientific observations.
Serologic markers in inflammatory bowel disease: state of the art. (2004)

A variety of serologic tests are emerging that are relevant to the diagnosis and treatment of Crohn's disease and ulcerative colitis. These laboratory tests include: anti-neutrophil cytoplasmic antibody with perinuclear staining (pANCA); anti-Saccharomyces cerevisiae antibody (ASCA); outer membrane porin C (Omp C); and I2 antibody (novel homologue of the bacterial transcription-factor families). The potential roles for serologic testing for inflammatory bowel disease (IBD) include adjunctive diagnostic testing in patients with known IBD, screening testing for IBD in patients with compatible gastrointestinal symptoms, and serving as a marker of unique disease course or prediction of response to specific treatments. This article reviews the use of pANCA, ASCA, I2, and Omp C in patients with IBD.
Cloud Storage and Processing Service Selection considering Tiered Pricing and Data Regulations (2022)

Most countries have come up with varied data privacy regulations. Some countries have stringent data storage and processing regulations, while others allow conditional data transfer across borders. For enterprises with geographically distributed data sources (users), it becomes challenging to select cloud data centers that meet data regulations and have minimal overall operational costs. In this work, we propose a joint optimization model for the selection of storage and processing services from multiple cloud service providers, taking into practical consideration of data regulations and tiered pricing, which has not been addressed in the prior art. To solve this hard multi-objective combinatorial optimization problem, we propose a greedy cost-reductionbased algorithm. The proposed algorithm gives multiple nondominating solutions, which are on average 2.5% away from the optimal solution. Further, we demonstrate the implications of data regulations and the benefits of joint optimization.
Hot spot management in ultra-low k 1 lithography (2006)

We have constructed a hot spot management flow for LSI manufacturing in the ultra-low k<sub>1</sub> lithography era. This flow involves three main management steps: hot spot reduction, hot spot extraction and hot spot monitoring. Hot spot reduction works for lithography friendly restriction (RDR) and manufacturability check (MC). Hot spot extraction is carried out with consideration of short turn-around-time (TAT), accurate extraction and convenient functions such as hot spot for interlayers. Hot spot monitoring is achieved with tolerance-based verification in mask fabrication process and wafer process (lithography and etching). These technology elements were integrated into the actual LSI fabrication flow. The application of this concept to LSI manufacturing could contribute to reduction of total cost, quick TAT and ramp up to volume production.
Detecting Periodic Subsequences in Cyber Security Data (2021)

Anomaly detection for cyber-security defence has garnered much attention in recent years providing an orthogonal approach to traditional signature-based detection systems. Anomaly detection relies on building probability models ofnormal computer network behaviour and detecting deviations from the model. Most data sets used for cyber-security have a mix of user-driven events and automated network events, which most often appears as polling behaviour. Separating these automated events from those caused by human activity is essential to building good statistical models for anomaly detection. In this article, we present a change point detection framework for identifying automated network events appearing as periodic subsequences of event times. The opening event of each subsequence is interpreted as a human action which then generates an automated, periodic process. Difficulties arising from the presence of duplicate and missing data are addressed. The methodology is demonstrated using authentication data from Los Alamos National Laboratory's enterprise computer network.
Solving Problems in an Uncertain World (2013)

The issue of problem solving in the context of incomplete or inconsistent information is a precursor to designing multiple agent planning systems. We present some general principles of planning and problem-solving in uncertainty, and instantiate these principles in a problem-solving system based on the NOAH planning system. The new NOAH system, working on the blocks world as a test domain, plans in certainty with the same efficacy as the original system, but can also handle a large class of errors caused by inconsistent or incomplete information.
Superantigen genes encoded by the egc cluster and SaPIbov are predominant among Staphylococcus aureus isolates from cows, goats, sheep, rabbits and poultry (2005)

In recent years several new staphylococcal enterotoxins (SEs) have been described, which currently have largely unknown frequencies of occurrence and roles in human or animal disease. One hundred and ninety-one Staphylococcus aureus isolates from cows (99), goats (39), sheep (23), rabbits (15), chickens (15) and a cat (1) were screened for SE genes sea-see, seg-seo and seq and for the tst gene encoding staphylococcal toxic shock syndrome toxin-1 using multiplex PCRs and individual PCRs for the seb and sek genes. One hundred and ten isolates tested positive for at least one of these 16 superantigen (SAg)-encoding genes. There were statistically significant differences in the frequencies of some of these SAg genes between isolates from different animals. No strain possessed either the sea or see gene. The sec gene was present in 51 isolates, the sed gene in eight and the seb gene in one. The seh gene was found in four strains and the sek and seq genes together in one isolate. The most common combinations of genes were the egc cluster, bearing the seg, sei, sem, sen and seo genes, in 47 isolates, the sec, sel and tst gene combination typical of the SaPIbov pathogenicity island in 44 isolates, the egc cluster lacking the seg gene in 11 isolates, the sed and sej genes in nine isolates, and the sec and tst genes without the sel gene in seven isolates. The higher frequencies of the sec and tst genes together and the lower frequencies of the egc gene cluster among the SAg gene-positive sheep or goat isolates compared to bovine isolates were statistically significant. Of 36 bovine isolates that were mitogenic for human T lymphocytes, four were negative for the 16 SAg genes tested for, while a further 14 gave borderline results in the mitogenicity assay, 12 of which were SAg gene-negative. Twenty-nine strains lacking all the SAg genes did not induce T-cell proliferation. This survey indicates that novel SE genes seg, sei, sel, sem, sen and seo along with the sec and tst genes predominate in S. aureus from animal hosts. The mitogenicity assays indicate that further uncharacterized SAgs may be present in bovine isolates.
A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres (2021)

Telomerase negative cancer cell types use the Alternative Lengthening of Telomeres (ALT) pathway to elongate telomeres ends. Here, we show that silencing human DNA polymerase (Pol λ) in ALT cells represses ALT activity and induces telomeric stress. In addition, replication stress in the absence of Pol λ, strongly affects the survival of ALT cells. In vitro, Pol λ can promote annealing of even a single G-rich telomeric repeat to its complementary strand and use it to prime DNA synthesis. The noncoding telomeric repeat containing RNA TERRA and replication protein A negatively regulate this activity, while the Protection of Telomeres protein 1 (POT1)/TPP1 heterodimer stimulates Pol λ. Pol λ associates with telomeres and colocalizes with TPP1 in cells. In summary, our data suggest a role of Pol λ in the maintenance of telomeres by the ALT mechanism.
Combined real time Ultrasound-thermometry and Elastography imaging during HIFU therapy: ex-vivo results (2010)

National audience
Enhanced Cell Penetration of Acid-Degradable Particles Functionalized with Cell-Penetrating Peptides (2008)

Biopharmaceuticals, such as proteins and DNA, have demonstrated their potential to prevent and cure diseases. The success of such therapeutic agents hinges upon their ability to cross complex barriers in the body and reach their target intact. In order to reap the full benefits of these therapeutic agents, a delivery vehicle capable of delivering cargo to all cell types, both phagocytic and non-phagocytic, is needed. This article presents the synthesis and evaluation of a microparticle delivery vehicle capable of cell penetration and sub-cellular triggered release of an encapsulated payload. pH-sensitive polyacrylamide particles functionalized with a polyarginine cell-penetrating peptide (CPP) were synthesized. The incorporation of a CPP into the microparticles led to efficient uptake by non-phagocytic cells in culture. In addition, the CPP-modified particles showed no cytotoxic effects at concentrations used in this study. The results suggest that these particles may provide a vehicle for the successful delivery of therapeutic agents to various cell types.
The Correlation of Increased Serum Prolactin Levels with Decreased Sexual Desire and Activity in Elderly Men (1983)

Serum prolactin levels and sexual function were evaluated in 28 men from 60 to 64 years of age and in 44 men from 65 to 70 years of age. All subjects were married, physically healthy, and had no psychopathology or marital problem. About a third of the men aged 60 to 70 years suffered from impotence. No obvious correlation between elevated levels of serum prolactin and impotence was obtained. Subjects aged 65 to 70 who had decreased libido exhibited a significant elevation of serum prolactin levels, while subjects of the same age group who had reserved (normal) libido appeared to have low serum prolactin levels. Nine of ten men aged 60 to 70 years with serum prolactin levels above 40 ng/ml reported decreased libido. Potent men of both age groups (60-70 years) with high prolactin levels showed a tendency to have a decrease in frequency of sexual intercourse. Thus, it seems that mild hyperprolactinemia in aging men may be associated with decreased sexual desire and frequency of sexual activity.
MEAN WEIGHT LOSS POST-ENDOSCOPIC SLEEVE GASTROPLASTY IS INDEPENDENT OF THE SUTURE PATTERN: RESULTS FROM A RANDOMIZED CONTROLLED TRIAL (2022)

Aims We compared the efficacy of three different suturing patterns in terms of weight loss after endoscopic sleeve gastroplastly.
Supplementary Table S1 from Androgen Receptor Signaling Regulates DNA Repair in Prostate Cancers (2023)

&lt;p&gt;Supplementary Table S1 - PDF file 170K, Gene set enrichment analysis of ARN-509-treated LNCaP-AR xenografts&lt;/p&gt;
Designing Protein Denaturants: Synthetic Agents Induce Cytochrome c Unfolding at Low Concentrations and Stoichiometries (2002)

The structural diversity and marginal stability (5–15 kcal mol−1) of proteins suggest the development of synthetic agents that selectively promote denaturation at low concentrations (see scheme). It is shown that an artificial receptor that binds tightly to the surface of native cytochrome c (cyt. c) lowers the melting temperature of the protein by 20°C at stoichiometric amounts; the receptor also selectively binds the native form rather than cyt. C551 and surface-modified cyt. c.