gebhart/patrepeval huggingface dataset:
The receptor super-antagonist Sant7 (1997)

Interleukin-6 (IL-6) plays a central role in the pathogenesis of multiple myeloma, acting both as a growth and a survival factor for myeloma cells. IL-6 has been recently shown to possess three topologically distinct receptor binding sites: site 1 for binding to the subunit specific chain IL-6R alpha and sites 2 and 3 for the interaction with two separate subunits of the signalling chain gp130. We have generated a set of IL-6 receptor antagonists carrying substitutions that abolish interaction with gp130 at either site 2 alone (site 2 antagonist) or at both sites 2 and 3 (site 2+3 antagonist). In addition, substitutions were introduced at site 1 that increased affinity for IL-6R alpha. When tested as growth inhibitors on a representative set of IL-6-dependent human myeloma cell lines (XG-1, XG-2, XG-4 and XG-6), although site 2 antagonists were effective on 3 out of 4 of the cell lines, only the site 2+3 antagonist Sant7 showed full antagonism on the entire spectrum of cells tested. Moreover, IL-6 receptor antagonists were also pro-apoptotic factors for myeloma cells. Their capacity to induce cell death was directly related to the impairment of binding to gp130 and to their ability to fully block intracellular signalling. In fact, the most potent inducer of apoptosis was again Sant7, which also counteracted the protective autocrine effect excercised by the endogenously produced IL-6. On the basis of these results we propose the super-antagonist Sant7 as a possible candidate for the immunotherapy of multiple myeloma.
10-Gb/s/ch QPSK FDM W-band radio-over-fiber signal generation, free-space radio transmission, and its demodulation (2011)

10-Gb/s/ch frequency-division-multiplexing (FDM) radio-over-fiber (RoF) signal generation and free-space transmission in W-band (75-110 GHz) are successfully demonstrated. The FDM quadrature-phaseshift-keying (QPSK) signals with 3 channels are optically generated and transmitted over 30-cm radio link. Digital signal processing with W-band mixer realizes successful demodulation of its FDM radio signal.
Lymphopenia combined with low TCR diversity (divpenia) predicts poor overall survival in metastatic breast cancer patients (2012)

Lymphopenia (< 1Giga/L) detected before initiation of chemotherapy is a predictive factor for death in metastatic solid tumors. Combinatorial T cell repertoire (TCR) diversity was investigated and tested either alone or in combination with lymphopenia as a prognostic factor at diagnosis for overall survival (OS) in metastatic breast cancer (MBC) patients. The combinatorial TCR diversity was measured by semi quantitative multi-N-plex PCR on blood samples before the initiation of the first line chemotherapy in a development (n = 66) and validation (n = 67) MBC patient cohorts. A prognostic score, combining lymphocyte count and TCR diversity was evaluated. Univariate and multivariate analyses of prognostic factors for OS were performed in both cohorts. Lymphopenia and severe restriction of TCR diversity called "divpenia" (diversity ≤ 33%) were independently associated with shorter OS. Lympho-divpenia combining lymphopenia and severe divpenia accurately identified patients with poor OS in both cohorts (7.6 and 10.6 vs 24.5 and 22.9 mo). In multivariate analysis including other prognostic clinical factors, lympho-divpenia was found to be an independent prognostic factor in the pooled cohort (p = 0.005) along with lack of HER2 and hormonal receptors expression (p = 0.011) and anemia (p = 0.009). Lympho-divpenia is a novel prognostic factor that will be used to improve quality of MBC patients' medical care.
Regulation-Oriented Filtering in Web-Based Air Traffic Exploration (2019)

Airspace route planning relies on many regulations and individual factors that can be hard to understand for audiences without advanced domain knowledge. This aspect is problematic if regulations are discussed in complex debates about changing air traffic distributions, affecting the broad public in negative and positive ways. To increase accessibility and transparency, we propose a regulation-oriented scheme of trajectory filters that includes a fully automated detection component for regulation deviations. The scheme further includes filters by daytime, custom areas, MTOM, and is part of a client-independent web prototype. In this publication, we specify details on individual filters and their inter- play (1st contribution), while putting a particular emphasis on the deviation detector (2nd contribution).
A digital readout technique for capacitive sensor applications (1988)

The difference between two capacitors is measured digitally using a charge redistribution technique incorporating a comparator, MOS switches, a successive approximation register, and a digital-to-analog converter. The technique is insensitive to comparator offset and parasitic capacitance, and the effect of MOS switch charge injection is measured and canceled. Extensive measurements have been made from test chips fabricated in 3- mu m CMOS technology. Detection of percent differences of <0.5% on 20-100-fF capacitors has been successfully demonstrated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Analytic performance model for speculative, synchronous, discrete-event simulation (2000)

Performance models exist that reliably describe the execution time and efficiency of parallel discrete-event simulations executed in a synchronous iterative fashion. These performance models incorporate the effects of processor heterogeneity, other processor load due to shared computational resources, application workload imbalance, and the use of speculative computation. This includes modeling the effects of predictive optimism, a technique for improving the accuracy of speculative assumptions. We extend these models to incorporate correlated workloads across the set of processors and validate the models with two different applications.
Triazole containing magnetic core-silica shell nanoparticles for Pb 2+ , Cu 2+ and Zn 2+ removal (2016)

International audience
ChemInform Abstract: A Very Active Cu‐Catalytic System for the Synthesis of Aryl, Heteroaryl, and Vinyl Sulfides. (2010)

Abstract The complex generated from CuI and cis‐1,2‐cyclohexanediol is highly efficient for the coupling of various thiols with vinyl, aryl, and heteroaryl iodides and bromides.
Pellino1 Is Required for Interferon Production by Viral Double-stranded RNA (2012)

Viral double-stranded RNA, a ligand for Toll-like Receptor 3 (TLR3) and the cytoplasmic RNA receptors RIG1 and MDA5, activate a signaling network in which the IKK-related protein kinase TBK1 phosphorylates the transcription factor Interferon Regulatory Factor 3 (IRF3) and the E3 ubiquitin ligase Pellino1. IRF3 then translocates to the nucleus where it stimulates transcription of the interferonβ (IFNβ) gene, but the function of Pellino1 in this pathway is unknown. Here, we report that myeloid cells and embryonic fibroblasts from knock-in mice expressing an E3 ligase-deficient mutant of Pellino1 produce reduced levels of IFNβ mRNA and secrete much less IFNβ in response to viral double-stranded RNA because the interaction of IRF3 with the IFNβ promoter is impaired. These results identify Pellino1 as a novel component of the signal transduction network by which viral double-stranded RNA stimulates IFNβ gene transcription.
Optimization of thin-film resistive-gate and capacitive-gate GaAs charge-coupled devices (1992)

Computer simulation of high-speed gallium arsenide charge coupled devices (CCDs) was performed using a two-dimensional semiconductor device simulation program. The measured performance of fabricated GaAs CCDs is compared with modeled results. The effect of active layer thickness and doping concentration on the charge transfer efficiency (CTE) and the dynamic range is investigated using different layers. Various gate architectures are compared for optimum dynamic range and compatibility with GaAs MESFET technology. The effect of clock shape on CTE is studied. Sensitivity analysis is performed on output structures. Both capacitive-gate CCD (CGCCD) and resistive-gate CCD (RGCCD) techniques are considered.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Determination of polarization field in a semipolar (112¯2) InGa∕GaN single quantum well using Franz–Keldysh oscillations in electroreflectance (2009)

We present an electroreflectance study of the polarization field in a semipolar (112¯2) oriented In0.12Ga0.88N quantum well. We demonstrate that the polarization field in a quantum well can be determined by the electric field in the barrier region measured by Franz–Keldysh oscillations. The polarization field is found to be 575±150kV∕cm, in the same direction as the built-in field. The corresponding polarization is 0.006±0.002C∕m2. Our experimental result indicates that in the semipolar InGaN∕GaN QW there is a crossover angle where the polarization field vanishes, and this crossover angle is less than 58°.
Towards Semi-Automatic Identification of Functional Requirements in Legal Texts for Public Administration (2013)

There is a need for the development of systems that are compliant with laws in public administration, because their administrative activities are based on laws. When new laws are made or existing laws are amended, however, civil servants need to develop or modify the systems in the short time before the laws are issued. Related work in requirements elicitation from the legal texts includes approaches using ontology but there are difficulties in building an ontology for practical use. In this paper we propose pre-defined templates with the expression of functional requirements to identify legal texts, including their functional requirements, and a support tool consisting of two functions, one for automatic summary creation from complicated legal texts and one for the suggestion of the legal texts, including their functional requirements. We have also applied this approach to Japanese laws and have evaluated its accuracy. Our research revealed that using this approach can identify functional requirements with high accuracy.
High-capacity Ka commercial communications satellite architectures for defense applications (2012)

This paper proposes multiple high capacity Ka satellite design options that can be used for resilient communications architectures for national security. These design options are strongly influenced by the emergence of high-throughput commercial narrow beam satellites that have recently been placed in service. Resilience requires rapid deployment of aggregate capacity, support for multiple connectivity patterns, flexibility in coverage areas including hot spots with high capacity density, compatibility with heterogeneous ground segments, and finally support for a variety of applications including fixed, ground mobile, maritime, and airborne. The paper analyzes performance of candidate architectures for driving requirements, provides costs estimates for acquisition and operations, and makes specific recommendations consistent with military interest in disaggregation of missions with smaller satellites and enhanced use of commercial SATCOM for government use.
On the Knowledge-Driven Analytics and Systems Impacting Human Quality of Life (2020)

The present scenario of Covid-19 pandemic has disrupted the human life to a larger extent. In such context, human-centric applications and systems that endeavor to positively impact the human quality of life is of utmost importance. Knowledge-driven analytics that help to build such intelligent systems play important role to construct the required eco-system on the macro-scale. It is worth mentioning that Knowledge-Driven Analytics and Systems Impacting Human Quality of Life (KDAH) workshop in ACM International Conference on Information and Knowledge Management (CIKM), attempts to bring out the intricate research direction for enabling a sustainable human society through the positive co-existence of human beings and intelligent systems.
Symbolic And Numeric Real-Time Signal Processing (1989)

We consider real-time sequential detection and estima-tion problems for non-gaussian signal and noise models. We develop optimal algorithms and several architectures for real-time implementation based on numerical algorithms, including asynchronous implementations of multigrid algorithms. These implementations are of high complexity, costly and cannot easily accomodate model variability. We then propose and analyze a different class of algorithms, which are symbolic, of the neural network type. The preliminary results presented here demonstrate that these algorithms have remarkably lower complexity and cost, work well under model variability and their performance is nearly optimal. We also discuss how these type of algorithms are incorporated in the DELPHI system for integrated design of signal processing systems.
A New Observation on the Stress Distribution in the Coronary Artery Wall (2009)

The stress distribution in the vessel wall has an important bearing on vascular function in health and disease. We studied the relationship between the transmural stress distribution and the opening angle (OA) to determine the stress gradient. The simulation of wall stress was based on transmural measurements of strain and material properties of coronary arteries in reference to the zero-stress state. A one-layer model with material constants of the intact vessel was used to calculate the circumferential stress distribution. A sensitivity analysis using both one- and two-layer models (intima-media and adventitia layers) was carried out to study the effect of the OA on the circumferential stress distribution and average circumferential stress. A larger OA always shifts the circumferential stress from the intima-media to the adventitia layer. We report a new observation that the circumferential stress at the adventitia may exceed that at the intima at physiological loading due to the larger OA in the porcine coronary artery. This has important implications for growth and remodeling, where an increase in opening angle may shift excessive stress from the inner layer to the outer layer.
Sexual-dimorphism in human immune system aging (2020)

Differences in immune function and responses contribute to health- and life-span disparities between sexes. However, the role of sex in immune system aging is not well understood. Here, we characterize peripheral blood mononuclear cells from 172 healthy adults 22-93 years of age using ATAC-seq, RNA-seq, and flow cytometry. These data reveal a shared epigenomic signature of aging including declining naïve T cell and increasing monocyte and cytotoxic cell functions. These changes are greater in magnitude in men and accompanied by a male-specific decline in B-cell specific loci. Age-related epigenomic changes first spike around late-thirties with similar timing and magnitude between sexes, whereas the second spike is earlier and stronger in men. Unexpectedly, genomic differences between sexes increase after age 65, with men having higher innate and pro-inflammatory activity and lower adaptive activity. Impact of age and sex on immune phenotypes can be visualized at https://immune-aging.jax.org to provide insights into future studies.
Direct Reduction of Carbon Dioxide to Formate in High‐Gas‐Capacity Ionic Liquids at Post‐Transition‐Metal Electrodes (2013)

As an approach to combat the increasing emissions of carbon dioxide in the last 50 years, the sequestration of carbon dioxide gas in ionic liquids has become an attractive research area. Ionic liquids can be made that possess incredibly high molar absorption and specificity characteristics for carbon dioxide. Their high carbon dioxide solubility and specificity combined with their high inherent electrical conductivity also creates an ideal medium for the electrochemical reduction of carbon dioxide. Herein, a lesser studied ionic liquid, 1-ethyl-3-methylimidazolium trifluoroacetate, was used as both an effective carbon dioxide capture material and subsequently as an electrochemical matrix with water for the direct reduction of carbon dioxide into formate at indium, tin, and lead electrodes in good yield (ca. 3 mg h(-1) cm(-2)).
Application of Operando X-ray Diffractometry in Various Aspects of the Investigations of Lithium/Sodium-Ion Batteries (2018)

The main challenges facing rechargeable batteries today are: (1) increasing the electrode capacity; (2) prolonging the cycle life; (3) enhancing the rate performance and (4) insuring their safety. Significant efforts have been devoted to improve the present electrode materials as well as to develop and design new high performance electrodes. All of the efforts are based on the understanding of the materials, their working mechanisms, the impact of the structure and reaction mechanism on electrochemical performance. Various operando/in-situ methods are applied in studying rechargeable batteries to gain a better understanding of the crystal structure of the electrode materials and their behaviors during charge-discharge under various conditions. In the present review, we focus on applying operando X-ray techniques to investigate electrode materials, including the working mechanisms of different structured materials, the effect of size, cycling rate and temperature on the reaction mechanisms, the thermal stability of the electrodes, the degradation mechanism and the optimization of material synthesis. We demonstrate the importance of using operando/in-situ XRD and its combination with other techniques in examining the microstructural changes of the electrodes under various operating conditions, in both macro and atomic-scales. These results reveal the working and the degradation mechanisms of the electrodes and the possible side reactions involved, which are essential for improving the present materials and developing new materials for high performance and long cycle life batteries.
The effect of comorbidity on hospital mortality in patients with SLE from an Asian tertiary hospital (2014)

The SLE burden is high in this population. Comorbidities and infectious disease were some of the most important contributors to hospital mortality and resource utilization.
Multimedia analysis and composition cloud service (2011)

Consumers increasingly desire to create and consume multimedia seamlessly from any of their devices wherever they happen to be. To meet this demand, multimedia services such as analysis and composition are increasingly moving to the cloud. This trend is enabling multimedia capabilities that can be accessed through mobile and social network applications as well as web browsers. In this paper, we discuss the architecture of a multimedia analysis and composition cloud service. We show examples of how this architecture can be used to provide browser-based multimedia applications, mobile applications, and social network applications, while comparing the advantages of each access method.
Conflicting Roles of Nickel in Controlling Cathode Performance in Lithium Ion Batteries (2012)

A variety of approaches are being made to enhance the performance of lithium ion batteries. Incorporating multivalence transition-metal ions into metal oxide cathodes has been identified as an essential approach to achieve the necessary high voltage and high capacity. However, the fundamental mechanism that limits their power rate and cycling stability remains unclear. The power rate strongly depends on the lithium ion drift speed in the cathode. Crystallographically, these transition-metal-based cathodes frequently have a layered structure. In the classic wisdom, it is accepted that lithium ion travels swiftly within the layers moving out/in of the cathode during the charge/discharge. Here, we report the unexpected discovery of a thermodynamically driven, yet kinetically controlled, surface modification in the widely explored lithium nickel manganese oxide cathode material, which may inhibit the battery charge/discharge rate. We found that during cathode synthesis and processing before electrochemical cycling in the cell nickel can preferentially move along the fast diffusion channels and selectively segregate at the surface facets terminated with a mix of anions and cations. This segregation essentially can lead to a higher lithium diffusion barrier near the surface region of the particle. Therefore, it appears that the transition-metal dopant may help to provide high capacity and/or high voltage but can be located in a "wrong" location that may slow down lithium diffusion, limiting battery performance. In this circumstance, limitations in the properties of lithium ion batteries using these cathode materials can be determined more by the materials synthesis issues than by the operation within the battery itself.
Interaction with volumetric displays (2008)

For almost 50 years, researchers have been exploring the use of stereoscopic displays for visualizing and interacting with three-dimensional (3D) data. Unfortunately, a number of unfavorable qualitative properties have impeded the wide-spread adoption of traditional 3D displays. The volumetric display, a more recent class of 3D display to emerge, possesses unique features which potentially makes it more suitable for integration into workplace, classroom, and even home environments. In this dissertation we investigate volumetric displays as an interactive platform for 3D applications. \nWe identify the inherent affordances unique to volumetric displays, such as their true 3D display volume, 360Â° viewing angle, and enclosing surface. Identifying these properties exposes human factor issues which we investigate and interaction issues which we address. First, we evaluate the userâs ability perceive imagery displayed by a volumetric display. In a formal experiment, we show that depth perception can be improved, in comparison to more traditional platforms. We then perform an experiment which evaluates usersâ ability to read text under 3D rotations, and present a new algorithm which optimizes text rotation when viewed my multiple users. Next, we investigate the userâs ability to select 3D imagery within the display. Results show that the dimension defining the depth of the object can constrain user performance as much as or more than the other two dimensions of the target. This leads us to explore alternative methods of selection which are less constraining to the user. We define a suite of new selection techniques, of which several are found to have significant benefits in comparison to techniques traditionally used in 3D user interfaces. Next, we describe our development of the first working interactive application, where a volumetric display is the sole device for input and display. The application presents a first glance at what the equivalent of todayâs graphical user interface might be on a volumetric display. We then develop a prototype application which allows multiple users to simultaneously interact with the volumetric display. We discuss and address the core issues related to providing such a collaborative user interface, and report feedback obtained from usage sessions and expert interviews.
The Sensitivity and Specificity of Pulmonary Carbon Dioxide Elimination for Noninvasive Assessment of Fluid Responsiveness (2015)

PEEP-induced changes in VCO2 predicted fluid responsiveness with accuracy in patients undergoing cardiac surgery.