gebhart/patrepeval huggingface dataset:
Hemostatic Treatment Using Factor VIII Concentrates for Neutralizing High-Responding Inhibitors Prior to CVAD Insertion for Immune-Tolerance Induction Therapy (2011)

We have utilized high-dose factor VIII (FVIII) concentrates in 4 hemophilia A patients with inhibitors prior to surgery for the insertion of a central venous access device. In total, 3 patients out of 4 had high responding inhibitors. Dosing algorithms for this type of therapy have not been previously validated and established. We devised an effective formula to calculate the initial dose required to neutralize the inhibitors, although some of the patients demonstrated a lower recovery of FVIII than expected. An anamnestic inhibitor response was evident in 3 cases, but overall our strategy provided a reliable hemostatic effect for at least 4 days after surgery. In addition, our protocol appeared to be more cost-effective than FVIII bypass therapy. The financial saving in 1 case for the initial 3 days was estimated to be approximately US$49 122. Our results demonstrated that high-dose FVIII therapy provided clinically effective and economically viable results even in high responders.
Antidiabetic potential of a long-acting derivative of GIP following once daily administration in type 2 diabetes. (2004)

The effect of a single treatment with cigarette smoke on the blood levels and hemodynamic effects of propranolol in rats was studied. Pentobarbital sleep time was not affected whereas zoxazolamine paralysis time was shortened 72% in rats, 24 h after the cigarette smoke exposure. The beta-adrenoceptor blocking effect of propranolol observed at 10 and 20 min time intervals was abolished in rats exposed to cigarette smoke 24 h after the exposure. The blood propranolol concentrations were decreased in rats pretreated with phenobarbital, 3,4-benzpyrene and ethanol as well as in cigarette smoke exposed rats. Among several factors that could influence propranolol metabolism, in this study, enzyme induction is suggested to be dominant.
Hafnium silicate gate dielectrics in GaN metal oxide semiconductor capacitors (2019)

Characteristics of hafnium silicate as gate dielectric in n-GaN capacitors were investigated. The Hf0.57Si0.43Ox, Hf0.64Si0.36Ox and HfO2 films exhibited high dielectric constants of 15.4, 15.9, and 17.6, respectively. The Hf0.57Si0.43Ox and Hf0.64Si0.36Ox films, which had an amorphous structure, showed superior properties, including a minimal flatband voltage (Vfb) hysteresis (≤70 mV) and a small Vfb shift (≤−0.45 V), as well as a low interface state density (~4 × 1011 cm−2 eV−1 at −0.4 eV from conduction band), and a high breakdown electric field (≥8.6 MV cm−1) compared to those of a polycrystalline HfO2 film.
SPONTANEOUS RETINAL REATTACHMENT IN INCONTINENTIA PIGMENTI (1998)

From The Wilmer Ophthalmological Institute, The Johns Hopkins Medical Institutions, Baltimore, Mankind.
Asp905Tyr Polymorphism of the Gene for the Skeletal Muscle-Specific Glycogen-Targeting Subunit of Protein Phosphatase 1 in NIDDM (1998)

These data suggest that the Asp905Tyr polymorphism of the PPP1R3 gene is not associated with NIDDM or high BMI, both of which are known to be insulin-resistant states, in the Japanese population.
Energetics of Metal−Ligand Multiple Bonds. Thermochemistry of Tantalum(V) Alkylidene Formation (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTEnergetics of Metal−Ligand Multiple Bonds. Thermochemistry of Tantalum(V) Alkylidene FormationLubin Luo, Liting Li, and Tobin J. MarksView Author Information Department of Chemistry Northwestern University Evanston, Illinois 60208-3113 Cite this: J. Am. Chem. Soc. 1997, 119, 36, 8574–8575Publication Date (Web):September 10, 1997Publication History Received28 April 1997Published online10 September 1997Published inissue 1 September 1997https://pubs.acs.org/doi/10.1021/ja971326jhttps://doi.org/10.1021/ja971326jrapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views262Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Aromatic compounds,Hydrocarbons,Metals,Self organization,Transition metals Get e-Alerts
Polyclonal antibody catalytic variability (1998)

We have performed a systematic variability study of polyclonal antibody catalysis by using five rabbits immunized with the same hapten. Important results from this work are the following. (1) Similarities were observed in the catalytic polyclonal antibodies derived from all five rabbits. Four of the five rabbits produced polyclonal samples that were nearly the same in terms of catalytic activity, whereas the fifth rabbit, designated as rabbit 2, displayed a somewhat higher level of catalytic activity. The catalytic activities (as kcat/kuncat) of these polyclonal samples were similar to that from the best murine monoclonal antibody that had been previously elicited by the same hapten. (2) Titre was not an accurate indicator of polyclonal antibody catalytic activity. (3) A mathematical analysis to describe a distribution of Michaelis-Menten catalysts was performed to help interpret our results. (4) Kinetic analysis indicated that the binding parameters of the different samples were remarkably homogeneous, because one or two components were all that were required to fit the on-rate and off-rate data satisfactorily. Interestingly, the most active catalytic polyclonal sample, that from rabbit 2, displayed the slowest off-rate (so slow it could not be measured) and thus the highest overall affinity. (5) Catalytic analysis of eluted fractions of antibody from a substrate column indicated that each polyclonal sample was also relatively homogeneous in terms of catalytic parameters. The main conclusion of our study is that for this hapten-animal system, the overall catalytic immune response is relatively consistent at two levels. Consistent catalytic activity was observed between the polyclonal samples elicited in the different animals, and the elicited hapten-specific polyclonal antibodies were relatively homogeneous in terms of binding and catalytic parameters within each immunized animal. The observed similarities of the catalytic activity in the different animals is surprising, because the immune response is based on specific binding of antibodies to hapten. There is no known selective pressure to maintain consistent levels of catalytic activity. Our results can therefore be interpreted as providing evidence that for this hapten there is a fixed relationship between hapten structure and catalytic activity and/or consistent genetic factors that dominate the catalytic immune response.
Advances in silicon oxynitride waveguides (2003)

The evolution of optical networks towards flexible many-wavelength systems with high data rates creates the need for a variety of novel optical devices. Reconfigurable optical components are required to re-route wavelength channels, and tunable compensating filter devices are necessary to control the optical properties of the signal carriers such as power, chromatic dispersion (CD) and polarization-mode dispersion (PMD). Silica-on-silicon planar waveguide technologies offer an ideal platform for the realization of such tunable components because of the excellent optical properties and compatibility with IC manufacturing tools. However, with increasing complexity, devices can become large with respect to the wafer size, which increases device cost. This can be overcome by a high-index-contrast silica technology. The small minimum bending radius leads to a reduced device size, and the overall reduction in waveguide dimensions results in a reduced processing time for deposition and etching. In this paper, we describe our high-index contrast technology based on silicon-oxynitride (SiON), and present two device examples.
Preference-based Session Management for Personalized Services (2003)

The increasing variety of mobile multimedia services raise the need for mechanisms to select those services that best match individual user requirements and allow for service customization. In this paper we describe an advanced concept for service personalization in next-generation IP-based mobile systems. Our approach extends conventional service management by introducing a preference order on the available service features according to the specific demands of a user. Furthermore, we exploit the fact that in current IP-based mobile communication systems application layer signaling messages traverse several network functional entities between client and server application. Our architectural solution based thereon comprises a stepwise refinement of profiles and preferences including an early matchmaking to service capabilities.
Development of an adaptable headspace sampling method for metabolic profiling of the fungal volatome (2018)

Pulmonary aspergillosis can cause serious complications in people with a suppressed immune system. Volatile metabolites emitted by Aspergillus spp. have shown promise for early detection of pathogenicity. However, volatile profiles require further research, as effective headspace analysis methods are required for extended chemical coverage of the volatome; in terms of both very volatile and semi-volatile compounds. In this study, we describe a novel adaptable sampling method in which fungal headspace samples can be sampled continuously throughout a defined time period using both active (pumped) and passive (diffusive) methods, with the capability for samples to be stored for later off-line analysis. For this method we utilise thermal desorption-gas chromatography-mass spectrometry to generate volatile metabolic profiles using Aspergillus fumigatus as the model organism. Several known fungal-specific volatiles associated with secondary metabolite biosynthesis (including α-pinene, camphene, limonene, and several sesquiterpenes) were identified. A comparison between the wild-type A. fumigatus with a phosphopantetheinyl transferase null mutant strain (ΔpptA) that is compromised in secondary metabolite synthesis, revealed reduced production of sesquiterpenes. We also showed the lack of terpene compounds production during the early growth phase, whilst pyrazines were identified in both early and late growth phases. We have demonstrated that the fungal volatome is dynamic and it is therefore critically necessary to sample the headspace across several time periods using a combination of active and passive sampling techniques to analyse and understand this dynamism.
Multiband sampling (2014)

In this chapter we consider sampling of multiband signals, namely, signals whose Fourier transform comprises a small number of bands, spread over a possibly wide frequency range. We begin by discussing the case in which the carrier frequencies, or band positions, are known. We review both classical methods and techniques based on interleaved ADC structures to sample such signals at a rate proportional to the actual band occupancy, and not to the high Nyquist rate associated with the highest frequency. The more challenging scenario in which the carrier frequencies are unknown, resulting in a union of subspace model, is treated next. Combining sampling approaches for the case in which the carriers are known, with methods for compressed sampling of analog signals developed in the previous chapter, leads to several sub-Nyquist sampling techniques for multiband signals with unknown band positions. Along with developing the theoretical concepts, we address practical constraints and present an example of a sub-Nyquist hardware realization for this class of signals.
A Static RAM as a Fault Model Evaluator (1987)

Abstract : This investigation considers the relationship between the physical failures that occur during fabrication and the resulting faulty behavior of the circuit. Fault models are used to describe the operation of integrated circuits containing physical failures introduced during fabrication. The effectiveness of fault models is dependent upon both the accuracy of the model and the occurrence of the underlying failure mechanism. A specially designed static RAM provides the size, design style, and testability required of a fault model test bed. An actual RAM implementation is described which was used for evaluation of fault models.
Table S5 from The MD Anderson Prostate Cancer Patient-derived Xenograft Series (MDA PCa PDX) Captures the Molecular Landscape of Prostate Cancer and Facilitates Marker-driven Therapy Development (2023)

&lt;p&gt;Table S5. List of 3022 genes differentially regulated between MDA PCa 146-10 and MDA PCa 146-12&lt;/p&gt;
Zfhx1a and Zfhx1b mRNAs have non-overlapping expression domains during chick and mouse midgestation limb development (2003)

Abstract Smad-interacting protein 1 (Zfhx1b, Sip1) and Zfhx1a (δEF1) are transcriptional repressors belonging to the family of two-handed zinc finger/homeodomain proteins. Both of the proteins bind to a bipartite CACCT/CACCTG DNA sequence, but only Sip 1 can interact with activated SMAD proteins in vitro. To gain insight into their developmental roles, we investigated the mRNA expression patterns of both genes in developing mouse and chick limbs by in situ hybridization. To improve the resolution of the expression mapping we have used a dual in situ hybridization (DISH) technique allowing for a detection of expression of two different mRNAs on the same tissue section. Using DISH we could demonstrate that both genes were expressed in distinct non-overlapping patterns in developing limbs of both species. Zfhx1a was expressed in a cell population immediately adjacent to cartilage anlagen as well as in developing tendons. Zfhx1b, in contrast, was present in a broad area around developing tendon and partially overlapping with the expression of genes associated with myogenic differentiation.
Identification of a repressor gene involved in the regulation of NAD de novo biosynthesis in Salmonella typhimurium (1988)

Mutations at the nadI locus affect expression of the first two genes of NAD synthesis, nadA and nadB, which are unlinked. Genetic data imply that the regulatory effects of nadI mutations are not due to indirect consequences of physiological alterations. Two types of mutations map in the nadI region. Common null mutations (nadI) show constitutive high-level expression of the nadB and nadA genes. Rare nadIs mutations cause constitutive low-level expression of nadB and nadA. Some nadIs mutations shut off the expression of the biosynthetic genes sufficiently to cause a nicotinic acid auxotrophy. Spontaneous revertants of auxotrophic nadIs mutants have a NadI- phenotype, including some with deletions of the nadI locus. The nadI locus encodes a repressor protein acting on the unlinked nadA and nadB genes.
Maudsley Hospital Survey: prevalence of alcohol problems and other psychiatric disorders in a hospital population (1988)

Summary This study, the first of its kind in the United Kingdom, reports on the prevalence of alcohol problems and other psychiatric disorders in the Joint Maudsley and Bethlem Royal Hospital population over a 12 year period. The steady 9–11% of the total number of diagnoses that are alcoholic, forces home the realization of the significant contribution of drinking problems to the work load of the hospital. The consistency of the percentage of alcoholics who receive an additional diagnosis, 30–40%, has considerable implications for treatment, treatment service planning and the understanding of aetiological factors.
Characterization of a helicon ion source for Helium-3 fusion in an inertial electrostatic confinement device (2011)

Summary form only given. An external helicon ion source is used on HELIOS, an inertial electrostatic confinement (IEC) fusion device in which ions are accelerated radially to fusion-relevant energies by the electrostatic field between the spherical chamber wall and a concentric cathode grid. The external ion source has allowed for the demonstration of <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> He- <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> He fusion in an IEC device for the first time, as part of the advanced fuels program at the University of Wisconsin. The experimental setup has been upgraded to allow for operation at higher ion current and cathode voltage levels, in order to increase the fusion rates for exploration of <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> He- <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> He reaction cross sections and future diagnostic studies to benchmark the single-atomic-species formalism of a numerical code on spherically convergent ion flow. Measurements of the plasma density and electron temperature in the helicon ion source are presented for different configurations of rf antenna and magnetic field geometries. Test results for a new high-voltage feed-through design are also presented.
Inhibition of steroid sulphatase activity in endometriotic implants by 667 COUMATE: a potential new therapy (2007)

The high levels of STS activity detected in ectopic endometrium and the correlation with severity of disease suggest that STS inhibitors could be useful for the treatment of endometriosis.
Gravitational Baryogenesis (2004)

We show that a gravitational interaction between the derivative of the Ricci scalar curvature and the baryon-number current dynamically breaks CPT in an expanding Universe and, combined with baryon-number-violating interactions, can drive the Universe towards an equilibrium baryon asymmetry that is observationally acceptable.
Toroidal Field Resistive Magnet Design for Tokamak Test Reactors (1983)

The design of resistive copper toroidal field (TF) coils is described for use in a nearterm tokamak fusion device (FED-R). A design requirement on the TF coils is that they contain readily demountable joints to facilitate replacement of components inside the bore of the coil. The coils are fabricated from rectangular window frame plates with 1-m-radius fillets in the inside corners. Each coil contains 17 turns — fabricated from CDA-110 copper plate segments 6.1 em thick. Because of high radiation fluence, a ceramic turn-to-turn insulator is used. The cooling system is sized to accommodate the combined heat loading that results from resistive power dissipation and nuclear heating.
Design and Analysis of a MEMS Based 1:N Monitored Protection Switch (2002)

The integrated MEMS 1:N protection switch, scalable to M:N protection is proposed that allows monitoring of the redundant network element during normal operation and of the failed network element during protection for diagnostic purposes. Design and analysis of the MEMS based protection switch are presented
Thermanaerovibrio velox sp. nov., a new anaerobic, thermophilic, organotrophic bacterium that reduces elemental sulfur, and emended description of the genus Thermanaerovibrio. (2000)

A moderately thermophilic, organotrophic bacterium with vibrioid cells was isolated from a sample of a cyanobacterial mat from caldera Uzon, Kamchatka, Russia, and designated strain Z-9701T. Cells of strain Z-9701T were curved, Gram-negative rods, 0.5-0.7 x 2.5-5.0 microm in size, with tapering ends and with fast, wavy movement by means of lateral flagella located on the concave side of the cell. Colonies were small, white, irregular or round, 0.2 mm in diameter, and with even edges. Strain Z-9701T was an obligate anaerobe with a temperature optimum at 60-65 degrees C and a pH optimum at 7.3. It fermented glucose, fructose, mannose, N-acetyl-D-glucosamine, adonite, arginine, serine, peptone, yeast extract and Casamino acids. The fermentation products formed during growth on glucose were acetate, lactate, H2, CO2 and ethanol. Strain Z-9701T reduced elemental sulfur to H2S during organotrophic growth with glucose or peptides as energy and carbon sources. In the presence of S0, strain Z-9701T was capable of lithotrophic growth with molecular hydrogen as energy substrate and 0.1 g yeast extract l(-1) as carbon source. Sulfate, thiosulfate, nitrate, Fe(III) and sulfite were not reduced and did not stimulate growth. The G+C content of strain Z-9701T DNA was 54.6 mol%. The results of 16S rDNA sequence analyses revealed that strain Z-9701T belongs to the cluster within the Clostridium group formed by Thermanaerovibrio acidaminovorans, Dethiosulfovibrio peptidovorans, Anaerobaculum thermoterrenum and Aminobacterium colombiense, but the level of sequence similarity with the members of this cluster was not very high (87.6-92.2%). Among these organisms, Thermanaerovibrio acidaminovorans is phenotypically close to strain Z-9701T. However, the two organisms showed a relatively low level of similarity of their 16S rRNA sequences (92.2%) and of DNA-DNA hybridization (15 +/- 1%). Nevertheless, on the basis of the similar morphology and physiology of the new isolate and Thermanaerovibrio acidaminovorans, strain Z-9701T was placed in the genus Thermanaerovibrio and a new species, Thermanaerovibrio velox, proposed for it. The type strain is Z-9701T (= DSM 12556T).
Neural networks and prior knowledge help the segmentation of medical images (1998)

This paper describes some achievements in the segmentation of medical images using artificial neural networks. We have identified three main sources of a priori information available to help perform the task of medical image segmentation: anatomical knowledge about the imaged district, the physical principles of image generation and the &amp;quot;regularities&amp;quot; of biological structures. The exploitation of each of these forms of knowledge can be effectively achieved with suitable neural architectures, three of which are described in the paper. An important lesson learnt from using these architectures is that different kinds of knowledge unavoidably induce different limitations in the resulting segmentation systems either in terms of generality or of performance. Our experience indicates that some of such limitations can be overcome through a careful exploitation and integration of available knowledge sources via proper neural modules. Keywords: Medical images, Computer vision, Image segmentatio...