gebhart/patrepeval huggingface dataset:
Terrain Adaptive Navigation for Mars Rovers (2007)

A navigation system for Mars rovers in very rough terrain has been designed, implemented, and tested on a research rover in Mars analog terrain. This navigation system consists of several technologies that are integrated to increase the capabilities compared to current rover navigation algorithms. These technologies include: goodness maps and terrain triage, terrain classification, remote slip prediction, path planning, high-fidelity traversability analysis (HFTA), and slip-compensated path following. The focus of this paper is not on the component technologies, but rather on the integration of these components. Results from the onboard integration of several of the key technologies described here are shown. Additionally, the results from independent demonstrations of several of these technologies are shown. Future work will include the demonstration of the entire integrated system.
High quality group-III metal nitride crystals, methods of making, and methods of use (2023)

High quality ammonothermal group III metal nitride crystals having a pattern of locally-approximately-linear arrays of threading dislocations, methods of manufacturing high quality ammonothermal group III metal nitride crystals, and methods of using such crystals are disclosed. The crystals are useful for seed bulk crystal growth and as substrates for light emitting diodes, laser diodes, transistors, photodetectors, solar cells, and for photoelectrochemical water splitting for hydrogen generation devices.
Genotypic Interaction of Early Maturity Soybean with Row Spacings (1989)

Previous research has demonstrated that soybean [ Glycine max (L.) Merr.] seed yields in the northern USA generally increase as row spacing is reduced. However, studies examining the consequences of a genotype ✕ row spacing interaction for seed yield on selection practices used to identify superior lines for use in wide and narrow row spacings have reported conflicting results. The objectives of this study were to: (i) examine the genotype ✕ row spacing interaction in preliminary breeding material of early maturity soybean; (ii) determine whether early maturing determinate genotypes respond similarly to indeterminate genotypes for yield in wide and narrow rows; and (iii) determine if information from whole plots or from parts of samples from one row spacing could be used to predict performance of genotypes in another row spacing. Two hundred and seventy‐six indeterminate and determinate genotypes of Maturity Groups 0, I, and early II were evaluated in six yield tests at two locations over 2 yr. Genotypes were planted in 25‐ and 76‐cm row spacings. Plant samples were taken from a 0.76 m 2 area of each plot to examine traits that might be useful in identifying superior genotypes for either row spacing. A genotype by row spacing interaction for seed yield was observed in four of the six tests. The determinate genotypes responded similarly to the indeterminate genotypes for yield in both row spacings. Of the traits measured, selection for mean seed yield was the most efficient characteristic in identifying superior yielding genotypes for use in either row spacing even if testing was limited to one row spacing. Generally, narrow rows were superior or equivalent to wide rows for identifying the best genotypes from preliminary yield tests for further testing in either row spacing.
Faculty Opinions recommendation of Fast Nanoliter-Scale Cell Assays Using Droplet Microarray-Mass Spectrometry Imaging. (2021)

In pharmaceutical research and development, cell-based assays are primarily used with readout that rely on fluorescence-based and other label-dependent techniques for analysis of different cellular processes. Superhydrophobic-hydrophilic droplet microarrays (DMA) and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) have recently emerged as key technologies for miniaturized high-throughput cell assays and for label-free molecular high-content drug profiling, respectively. Here, nanoliter-scale cell assays are integrated on DMAs with MALDI-MS imaging (MALDI-MSI) approaches to a droplet microarray-mass spectrometry imaging (DMA-MSI) platform. Using A549 lung cancer cells, concentration-response profiling of a pharmaceutical compound, the fatty acid synthase inhibitor GSK2194069, are demonstrated. Direct cell culture on DMAs enables combination of microscopy and high speed, high molecular content analysis using MALDI-MSI. Miniaturization of array spots down to 0.5 mm confining 40 nL droplets allows for MALDI imaging analysis of as few as ten cells per spot. Partial automation ensures a fast sample preparation workflow. Taken together, the integrated DMA-MSI platform that combines MALDI-MSI, as a label-free analytical readout, with the miniaturized droplet microarray platform is a valuable complement to high throughput cell-based assays technologies.© 2021 The Authors. Advanced Biology published by Wiley-VCH GmbH. PMID: 33729695 Funding information This work was supported by: Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg, Grant ID: MALDIDROPScreen 7533-7-11.10-12
Data from Carbon Nanotubes Enhance CpG Uptake and Potentiate Antiglioma Immunity (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Stimulation of toll-like receptor-9 (TLR9) by CpG oligodeoxynucleotides (CpG) has been shown to counteract the immunosuppressive microenvironment and to inhibit tumor growth in glioma models. Because TLR9 is located intracellularly, we hypothesized that methods that enhance its internalization may also potentiate its immunostimulatory response. The goal of this study was to evaluate carbon nanotubes (CNT) as a CpG delivery vehicle in brain tumor models.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Functionalized single-walled CNTs were conjugated with CpG (CNT–CpG) and evaluated &lt;i&gt;in vitro&lt;/i&gt; and in mice bearing intracranial GL261 gliomas. Flow cytometry was used to assess CNT–CpG uptake and antiglioma immune response. Tumor growth was measured by bioluminescent imaging, histology, and animal survival.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; CNT–CpG was nontoxic and enhanced CpG uptake both &lt;i&gt;in vitro&lt;/i&gt; and intracranial gliomas. CNT-mediated CpG delivery also potentiated proinflammatory cytokine production by primary monocytes. Interestingly, a single intracranial injection of low-dose CNT–CpG (but not free CpG or blank CNT) eradicated intracranial GL261 gliomas in half of tumor-bearing mice. Moreover, surviving animals exhibited durable tumor-free remission (&gt;3 months), and were protected from intracranial tumor rechallenge, demonstrating induction of long-term antitumor immunity.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; These findings suggest that CNTs can potentiate CpG immunopotency by enhancing its delivery into tumor-associated inflammatory cells. &lt;i&gt;Clin Cancer Res; 17(4); 1–12. ©2010 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Seipin Knockout Mice Develop Heart Failure With Preserved Ejection Fraction (2019)

The lean diabetic patients with heart failure with preserved ejection fraction (HFpEF) in Asia suffer from adverse clinical outcomes and poor life quality. The suitable animal models are urgently needed for mechanistic study and therapeutic innovations. Our study reports that lipodystrophic mice with seipin depletion are lean, diabetic, and recapitulate major manifestations of clinical HFpEF, thereby clarifying that lean diabetes per se may produce HFpEF characteristics. We further demonstrate that increased cardiac titin phosphorylation and reactive interstitial fibrosis associated with neutrophil extracellular traps lead to left ventricular stiffness and suggest that both pathways may be potential therapeutic targets in Asian HFpEF patients.
Cloud-native workflow scheduling using a hybrid priority rule and dynamic task parallelism (2022)

Demand for efficient cloud-native workflow scheduling is growing as many data science workloads are composed of several tasks with dependencies. As container technology becomes more prevalent in cloud communities, containerized workflow orchestration tools are introduced and become standard for scheduling workflows. However, current schedulers use simple heuristics and rely on the user's choice on priority and parallelism level of tasks without accounting for workflow-specific information.
Morphology of poly(phthalocyaninatogermoxane) crystals (1985)

Abstract The morphology of fully and partially polymerized poly(phthalocyaninatogermoxane), [Ge(Pc)O] n , crystals was studied by both scanning and transmission electron microscopy. It was found that the morphological units are lath‐like crystals which aggregate into particles. Generally speaking, the thickness, width, and length of the laths are in the range of 1000–2000 Å, 2000–10,000 Å, and 1–5 μm, respectively. Each lath may possess a mosaic substructure. Selected‐area electron diffraction patterns indicate that the rigid, extended [Ge(Pc)O] n chains are parallel to the large surface of the lath, and in most crystals the chains lie parallel to the lengthwise direction of the lath. However, in several cases, the chain orientation is at an angle of about 60° with respect to the long edge of the lath. The electron diffraction results are in accord with a tetragonal crystal structure (P4/m).
Acoustics of National Parks and Historic Sites: the 8,760 hour MP3 File (2009)

According to current U.S. National Park Service (NPS) management policies, the natural soundscape of parks and historic sites is a protected resource just like the ecosystems, landscapes, and historic artifacts for which the parks were formed. While several NPS sites have been studied extensively for noise intrusions by tour aircraft and mechanized recreation, most parks and historic sites do not yet have an acoustic baseline for management purposes. A recent initiative of the NPS Natural Sounds Office is to obtain continuous audio recordings of specific sites for one entire year. This paper explores the engineering and scientific issues associated with obtaining, archiving, and cataloging an 8,760 hour long audio recording for Grant-Kohrs Ranch National Historic Site.
Supplementary Figure 2 from Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling (2023)

&lt;p&gt;The synergy in the MAPK pathway suppression and anti-proliferation effect by KRASG12C inhibitor and TNO155.&lt;/p&gt;
Chemical Characterization of Non-Saccharidic and Saccharidic Components of Rapeseed Hulls and Sunflower Shells (2017)

International audience
2123 Quantification of inflow effects in 3D cardiac imaging: implications for 3D whole-heart coronary artery and vein imaging (2008)

Address: 1Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA, 2Philips Research North America, Briarcliff Manor, NY, USA, 3Philips Research Europe, Hamburg, Germany and 4Department of Medicine (Cardiovascular Division) Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA * Corresponding author
Photobiomodulation for Parkinson’s Disease in Animal Models: A Systematic Review (2020)

Photobiomodulation (PBM) might be an effective treatment for Parkinson's disease (PD) in human patients. PBM of the brain uses red or near infrared light delivered from a laser or an LED at relatively low power densities, onto the head (or other body parts) to stimulate the brain and prevent degeneration of neurons. PD is a progressive neurodegenerative disease involving the loss of dopamine-producing neurons in the substantia nigra deep within the brain. PD is a movement disorder that also shows various other symptoms affecting the brain and other organs. Treatment involves dopamine replacement therapy or electrical deep brain stimulation. The present systematic review covers reports describing the use of PBM to treat laboratory animal models of PD, in an attempt to draw conclusions about the best choice of parameters and irradiation techniques. There have already been clinical trials of PBM reported in patients, and more are expected in the coming years. PBM is particularly attractive as it is a non-pharmacological treatment, without any major adverse effects (and very few minor ones).
Integration and Electrical Properties of Carbon Nanotube Array for Interconnect Applications (2006)

Carbon nanotube (CNT) vertical integration and electrical properties are presented in full 6-inch wafer for interconnect applications. Series array of 1000 vias made of vertically grown CNTs is obtained with uniform electrical resistances within the wafer. Integration processes are implemented by following sequential steps: bottom electrode and via hole patterning, CNT growth and planarization, and top electrode patterning in a 6-inch wafer. Multiwall carbon nanotubes (MWNTs) are used for interconnection, titanium nitride for the bottom electrode, and aluminum with titanium adhesion layer for the top electrode. We have demonstrated well-defined CNT via series interconnection with 700 nm via diameters within the full wafer. Via resistance of 1.2 kΩ with CNT density of 2.7×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10</sup> /cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> is obtained with small resistance variation within the wafer, which also corresponds to 176 kΩ per one MWNT with 10 nm diameters. The possible approaches for further decrease of electrical resistance will be suggested.
(Invited) New Approaches for Shrinking the Performance Gap for GaN Power Devices (2017)

The expected performance of GaN and SiC based power devices far exceeds that of Si power transistors, but the gap between the expected and achieved performance is much larger for GaN transistors. In this paper, we discuss new approaches for shrinking the performance gap for GaN power devices. They include using the quantum well channel designs that lead to the electron wave function penetration into wide band gap cladding layers with the commensurate increase in the breakdown voltage while keeping the advantage of a high mobility in the device channel. The gate edge engineering (beyond just using field plates) optimizes the voltage distribution in the drain-to-gate spacing. It could be combined with a low conducting passivation for smoothing or even eliminating the sharp maximum of the electric field in the vicinity of the gate and field plate edges. Additional contacts in the drain-to-gate spacing for the field control and variable doping implants should allow for further optimization. The perforated channel designs could alleviate both the parasitic series resistance problem and the heat dissipation problem. Extending the gate perforations into the drain-to-gate region allows for a considerable reduction of the switching RC constant with a commensurate decrease in power dissipation. The ultimate design could use the lateral-vertical structures. The AlInN/AlN/GaN technology is uniquely poised for the breakthrough in high temperature performance. We predict that the combination of these approaches will dramatically shrink the performance gap firmly establishing GaN as a superb material for power applications.
Fluorescence lifetime imaging for biomedicine and spectroscopy (2002)

Summary form only. The determination of fluorescence lifetime requires only relative intensity measurements and so is especially useful for biomedical samples in which the heterogeneous nature of tissue and autofluorescence present significant problems. Since fluorescence lifetime is dependent upon both radiative and nonradiative decay rates, it may be used to distinguish between different fluorophore molecules (with different radiative decay rates) and to monitor local environmental perturbations that affect the nonradiative decay rate. Fluorescence lifetime imaging (FLIM) can be applied to almost any optical imaging modality, including microscopy and potentially to noninvasive optical biopsy. Fluorescence lifetime data may be acquired in the time or frequency domains. The recent development of user-friendly and relatively portable ultrafast laser technology and the availability of ultrafast gated optical image intensifiers (GOI) enable the development of relatively inexpensive time domain FLIM instruments that may be deployed outside specialist laser laboratories. We report a time domain FLIM system that incorporates an all-solid-state diode-pumped Cr:LiSGAF oscillator-amplifier system combined with a GOI. This laser system requires only four 500 mW pump diodes and will run off a domestic power outlet with minimal water-cooling requirements.
A Concise Asymmetric Synthesis of the Potent Enkephalinase Inhibitor Kelatorphan (1992)

Abstract A concise asymmetric synthesis of the enkephalinase inhibitor Kelatorphan has been completed in seven steps from commercially available hydrocinnamyl chloride. The synthesis features as a key step an asymmetric C-C bond formation which utilizes Oppolzer bornane-sultam alkylation methodology.
Improved real-time delay-multiply-and-sum beamforming with coherence factor (2020)

Delay-and-sum (DAS) beamforming is the most commonly used algorithm to form photoacoustic (PA) and ultrasound (US) images because of its simple implementation. However, it has several drawbacks such as low image resolution and contrast. To deal with this problem, delay-multiply-and-sum (DMAS) beamforming algorithm was developed a few years ago. It is known that DMAS can improve the image quality by providing higher contrast and narrower main lobe compared to DAS, but its calculation speed is too slow to be implemented for clinical applications. Herein, we introduce an improved DMAS in terms of both imaging speed and quality, and we demonstrated real-time clinical PA imaging. The proposed DMAS provided better lateral resolution and signal-to-noise ratio (SNR) than the original DMAS through a modified coherence factor. Then we accelerated its computation speed by optimizing the algorithm and parallelizing the process using a graphics processing unit (GPU). We quantitatively compared the processing time and the image quality of the proposed algorithm with the conventional algorithms. As the result, it was observed that our proposed algorithm showed better spatial resolution and SNR while achieving real-time imaging framerate. Due to the improvement, the proposed algorithm was successfully implemented on a programmable clinical PA/US imaging system and showed clearer real-time PA images than the conventional DAS images.
A Provably Secure Lattice-Based Fuzzy Signature Scheme Using Linear Sketch (2023)

Fuzzy signatures (FS) are a kind of signature scheme that employs a noisy string (e.g., biometric data) as the secret key without requiring the user-specific auxiliary data. As the quantum computing era approaches, some research has been dedicated to developing quantum-resistant FS schemes, which can be classified into fuzzy extractor (FE) approach and linear sketch (LS) approach. However, the existing schemes utilizing FEs to obtain (variants of) fuzzy signatures require to produce the user-specific auxiliary information known as helper data to retrieve secret keys, leading to an additional computational cost. In light of the circumstance, we seek to construct a fuzzy signature scheme by employing a linear sketch, since this approach does not require the user-specific auxiliary data to derive secret keys. We modify the linear sketch which is an essential ingredient of the most practical fuzzy signature proposed by Katsumata et al. (CCS’ 21). Then we combine it with Lyubashevsky’s lattice-based signature scheme (EUROCRYPT’ 12) to construct our lattice-based fuzzy signature scheme. Moreover, to further demonstrate the security of our proposed scheme, we provide a rigorous security proof in the random oracle model. Finally, the comparison indicates that our proposed FS scheme not only avoids the use of FE but also shows a promising tendency in efficiency among the existing quantum-resistant FS schemes.
Airport surface area propagation path loss in the VHF band (2011)

The wireless channel in the very high frequency (VHF) band at airport surface areas has not been quantitatively characterized in several ways. As new communication services are introduced, and as the band's spectral efficiency must be increased, a quantitative characterization of this channel will become critical for advanced wireless networking [1]. This paper describes a first step in this direction: measurement and modeling of propagation path loss in the VHF band [2]. Narrowband measurements were made in the aeronautical VHF band at Detroit Metropolitan Airport (DTW). A continuous wave (sinusoidal) signal was transmitted from existing VHF radio transmitter-receiver (RTR) sites, and a mobile receiver moved about the airport surface area in a prescribed path. Propagation path loss was computed using basic link budget analyses. Results for both line-of-sight (LOS) and non-line-of-sight (NLOS) conditions are provided using the log-distance path loss model. The mean propagation path loss exponents are found to be approximately 5.6 and 4 for NLOS and LOS regions, respectively. Results for LOS regions also correspond to the well-known “2-ray,” or “plane-earth” model.
Editorial Comments (1990)

No AccessJournal of Urology1 Sep 1990Editorial Comments Ralph V. Clayman Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)48000-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial Comments." The Journal of Urology, 144(3), p. 630 © 1990 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 144Issue 3September 1990Page: 630 Advertisement Copyright & Permissions© 1990 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Ralph V. Clayman More articles by this author Expand All Advertisement Loading ...
Role of SOX17 in hematopoietic development from human embryonic stem cells (2012)

To search for genes that promote hematopoietic development from human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), we overexpressed several known hematopoietic regulator genes in hESC/iPSC-derived CD34(+)CD43(-) endothelial cells (ECs) enriched in hemogenic endothelium (HE). Among the genes tested, only Sox17, a gene encoding a transcription factor of the SOX family, promoted cell growth and supported expansion of CD34(+)CD43(+)CD45(-/low) cells expressing the HE marker VE-cadherin. SOX17 was expressed at high levels in CD34(+)CD43(-) ECs compared with low levels in CD34(+)CD43(+)CD45(-) pre-hematopoietic progenitor cells (pre-HPCs) and CD34(+)CD43(+)CD45(+) HPCs. Sox17-overexpressing cells formed semiadherent cell aggregates and generated few hematopoietic progenies. However, they retained hemogenic potential and gave rise to hematopoietic progenies on inactivation of Sox17. Global gene-expression analyses revealed that the CD34(+)CD43(+)CD45(-/low) cells expanded on overexpression of Sox17 are HE-like cells developmentally placed between ECs and pre-HPCs. Sox17 overexpression also reprogrammed both pre-HPCs and HPCs into HE-like cells. Genome-wide mapping of Sox17-binding sites revealed that Sox17 activates the transcription of key regulator genes for vasculogenesis, hematopoiesis, and erythrocyte differentiation directly. Depletion of SOX17 in CD34(+)CD43(-) ECs severely compromised their hemogenic activity. These findings suggest that SOX17 plays a key role in priming hemogenic potential in ECs, thereby regulating hematopoietic development from hESCs/iPSCs.