gebhart/patrepeval huggingface dataset:
Carbon fiber and void detection using high-frequency electromagnetic induction techniques (2016)

Ultrawide band electromagnetic induction (EMI) instruments have been traditionally used to detect high electric conductivity discrete targets such as metal unexploded ordnance. The frequencies used for this EMI regime have typically been less than 100 kHz. To detect intermediate conductivity objects like carbon fiber, even less conductive saturated salts, and even voids embedded in conducting soils, higher frequencies up to the low megahertz range are required in order to capture characteristic responses. To predict EMI phenomena at frequencies up to 15 MHz, we first modeled the response of intermediate conductivity targets using a rigorous, first-principles approach, the Method of Auxiliary Sources. A newly fabricated benchtop high-frequency electromagnetic induction instrument produced EMI data at frequencies up to that same high limit. Modeled and measured characteristic relaxation signatures compare favorably and indicate new sensing possibilities in a variety of scenarios.
Binding of the Heterogeneous Ribonucleoprotein K (hnRNP K) to the Epstein-Barr Virus Nuclear Antigen 2 (EBNA2) Enhances Viral LMP2A Expression (2012)

The Epstein-Barr Virus (EBV) -encoded EBNA2 protein, which is essential for the in vitro transformation of B-lymphocytes, interferes with cellular processes by binding to proteins via conserved sequence motifs. Its Arginine-Glycine (RG) repeat element contains either symmetrically or asymmetrically di-methylated arginine residues (SDMA and ADMA, respectively). EBNA2 binds via its SDMA-modified RG-repeat to the survival motor neurons protein (SMN) and via the ADMA-RG-repeat to the NP9 protein of the human endogenous retrovirus K (HERV-K (HML-2) Type 1). The hypothesis of this work was that the methylated RG-repeat mimics an epitope shared with cellular proteins that is used for interaction with target structures. With monoclonal antibodies against the modified RG-repeat, we indeed identified cellular homologues that apparently have the same surface structure as methylated EBNA2. With the SDMA-specific antibodies, we precipitated the Sm protein D3 (SmD3) which, like EBNA2, binds via its SDMA-modified RG-repeat to SMN. With the ADMA-specific antibodies, we precipitated the heterogeneous ribonucleoprotein K (hnRNP K). Specific binding of the ADMA- antibody to hnRNP K was demonstrated using E. coli expressed/ADMA-methylated hnRNP K. In addition, we show that EBNA2 and hnRNP K form a complex in EBV- infected B-cells. Finally, hnRNP K, when co-expressed with EBNA2, strongly enhances viral latent membrane protein 2A (LMP2A) expression by an unknown mechanism as we did not detect a direct association of hnRNP K with DNA-bound EBNA2 in gel shift experiments. Our data support the notion that the methylated surface of EBNA2 mimics the surface structure of cellular proteins to interfere with or co-opt their functional properties.
Testing of Operating Systems (2014)

An operating system is a base stone of any computer system. Failures and bugs in operating system impact the functionality of the system as a whole, that is why correctness and reliability of operating systems are so important. A variety of circumstances make verification and testing of operating systems a complicated issue. The list includes high dependence of operating systems on hardware, their massive internal concurrency, huge number of configuration options, required tolerance to aggressive actions of counteragents and hardware faults, a need for long continuous work without reboot, etc. The paper discusses influence of all the circumstances on testing, describes testing tools and techniques developed in ISPRAS and presents our experience of testing of various components of Linux as well as a few other real-time operating systems.
Sågtandande polyper en dold men vanlig orsak till kolorektal cancer : Serrated polyps is a hidden but common cause of colorectal cancer (2015)

Konceptet att sågtandande polyper kan leda till kolorektal cancer är relativt nytt. Sågtandade polyper orsakar upp till en tredjedel av all sporadisk kolorektal cancer. Trots detta är kunskaperna om sågtandade polypers etiologi, incidens, prevalens och naturalförlopp ofullständiga. Sågtandade polyper är svåra att identifiera och ta bort endoskopiskt. Endoskopister och patologer måste ha kunskaper om sågtandade adenom för att effektivt kunna detektera, diagnostisera och ta bort dem som led i att minska antalet personer som drabbas av kolorektal cancer. The concept that serrated polyps can cause colorectal cancer is relatively new and not very well-known. Serrated polyps are difficult to identify and treat endoscopically. This together with the fact that premalignant serrated polyps are mainly located in the proximal colon might help explain why colonoscopy is less effective against right-sided compared to left-sided colorectal cancers and why interval cancers usually appear in the proximal colon. In fact, serrated polyps may cause up to one third of all sporadic colorectal cancers. In spite of this, the aetiology, incidence, prevalence and natural history of serrated polyps remains elusive. Endoscopists and pathologists must have a good understanding of serrated polyps in order to effectively diagnose, treat and follow up these lesions. This review focuses on the pathophysiology, types, work-up, treatment and follow-up of serrated polyps in the colon and rectum.
Recent Progress of CO<SUB>2</SUB> Laser Sheet-Metal Cutting Systems (2008)

Recent progress of CO2 laser sheet-metal cutting systems is described. The CO2 laser is still the front-runner for industrial laser market, however more than two decades have passed since the CO2 laser cutting system entered the market. The power scaling of laser oscillator has enhanced the productivity of systems, and the advance of the processing technology has drastically improved the cutting quality. We believe that the CO2 laser cutting systems will be more practical industrial tools by continuous developments for wide range of applications.
Design and Synthesis of 4‐Phenyl Piperidine Compounds Targeting the Mu Receptor. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
An intramolecular Diels-Alder reaction of vinylsilanes. [Erratum to document cited in CA117(15):151058k] (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleAn intramolecular Diels-Alder reaction of vinylsilanes. [Erratum to document cited in CA117(15):151058k]Scott M. Sieburth and Louis FensterbankCite this: J. Org. Chem. 1993, 58, 12, 3472Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/jo00064a047https://doi.org/10.1021/jo00064a047research-articleACS PublicationsRequest reuse permissionsArticle Views56Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Study on Multi-DOF Ultrasonic Actuator for Laparoscopic Instrument (2004)

In surgical robots, compact manipulators with multi-degree-of-freedom (DOF) are essential owing to a small work volume in the patient body. Conventional single-DOF actuators such as electromagnetic motors require a multiple number of actuators to generate multi-DOF motion, which in turn results in bulky mechanism combined with transmission device. Our previous work has developed a compact ultrasonic motor capable of generating a multi-DOF rotation of a spherical rotor utilizing three natural vibration modes of a bar-shaped stator. The present study designs and builds a novel multi-DOF master-slave system for laparoscopic surgical procedures, using a single ultrasonic actuator. The system consists of surgical forceps on multi-DOF wrist with joystick controller. Experimental results have confirmed high responsiveness and precise position control of the master-slave system.
Comparison of Supervised Classification Methods for Protein Profiling in Cancer Diagnosis (2007)

A key challenge in clinical proteomics of cancer is the identification of biomarkers that could allow detection, diagnosis and prognosis of the diseases. Recent advances in mass spectrometry and proteomic instrumentations offer unique chance to rapidly identify these markers. These advances pose considerable challenges, similar to those created by microarray-based investigation, for the discovery of pattern of markers from high-dimensional data, specific to each pathologic state (e.g. normal vs cancer). We propose a three-step strategy to select important markers from high-dimensional mass spectrometry data using surface enhanced laser desorption/ionization (SELDI) technology. The first two steps are the selection of the most discriminating biomarkers with a construction of different classifiers. Finally, we compare and validate their performance and robustness using different supervised classification methods such as Support Vector Machine, Linear Discriminant Analysis, Quadratic Discriminant Analysis, Neural Networks, Classification Trees and Boosting Trees. We show that the proposed method is suitable for analysing high-throughput proteomics data and that the combination of logistic regression and Linear Discriminant Analysis outperform other methods tested.
IP-Based Mobile and Fixed Network Audiovisual Media Services (2011)

This article provides a tutorial overview of current approaches for monitoring the quality perceived by users of IP-based audiovisual media services. The article addresses both mobile and fixed network services such as mobile TV or Internet Protocol TV (IPTV). It reviews the different quality models that exploit packet- header-, bit stream-, or signal-information for providing audio, video, and audiovisual quality estimates, respectively. It describes how these models can be applied for real-life monitoring, and how they can be adapted to reflect the information available at the given measurement point. An outlook gives insight into emerging trends for near- and mid-term future requirements and solutions.
Genome-wide transcriptome analysis reveals that a pleiotropic antibiotic regulator, AfsS, modulates nutritional stress response in Streptomyces coelicolor A3(2) (2008)

Our data suggests a comprehensive role for S. coelicolor AfsS as a master regulator of both antibiotic synthesis and nutritional stress response, reminiscent of alternative sigma factors found in several bacteria.
Electrophysiological investigation of intact retina with soft printed organic neural interface (2021)

<i>Objective.</i>Understanding how the retina converts a natural image or an electrically stimulated one into neural firing patterns is the focus of on-going research activities.<i>Ex vivo</i>, the retina can be readily investigated using multi electrode arrays (MEAs). However, MEA recording and stimulation from an intact retina (in the eye) has been so far insufficient.<i>Approach.</i>In the present study, we report new soft carbon electrode arrays suitable for recording and stimulating neural activity in an intact retina. Screen-printing of carbon ink on 20<i>µ</i>m polyurethane (PU) film was used to realize electrode arrays with electrodes as small as 40<i>µ</i>m in diameter. Passivation was achieved with a holey membrane, realized using laser drilling in a thin (50<i>µ</i>m) PU film. Plasma polymerized 3.4-ethylenedioxythiophene was used to coat the electrode array to improve the electrode specific capacitance. Chick retinas, embryonic stage day 13, both explanted and intact inside an enucleated eye, were used.<i>Main results.</i>A novel fabrication process based on printed carbon electrodes was developed and yielded high capacitance electrodes on a soft substrate.<i>Ex vivo</i>electrical recording of retina activity with carbon electrodes is demonstrated. With the addition of organic photo-capacitors, simultaneous photo-electrical stimulation and electrical recording was achieved. Finally, electrical activity recordings from an intact chick retina (inside enucleated eyes) were demonstrated. Both photosensitive retinal ganglion cell responses and spontaneous retina waves were recorded and their features analyzed.<i>Significance.</i>Results of this study demonstrated soft electrode arrays with unique properties, suitable for simultaneous recording and photo-electrical stimulation of the retina at high fidelity. This novel electrode technology opens up new frontiers in the study of neural tissue<i>in vivo</i>.
Path Cover and Path Pack Inequalities for the Capacitated Fixed-Charge Network Flow Problem (2017)

Capacitated fixed-charge network flows are used to model a variety of problems in telecommunication, facility location, production planning and supply chain management. In this paper, we investigate capacitated path substructures and derive strong and easy-to-compute \emph{path cover and path pack inequalities}. These inequalities are based on an explicit characterization of the submodular inequalities through a fast computation of parametric minimum cuts on a path, and they generalize the well-known flow cover and flow pack inequalities for the single-node relaxations of fixed-charge flow models. We provide necessary and sufficient facet conditions. Computational results demonstrate the effectiveness of the inequalities when used as cuts in a branch-and-cut algorithm.
Quantitative Electron Probe Analysis of Zeolites (2004)

Extended abstract of a paper presented at Microscopy and Microanalysis 2004 in Savannah, Georgia, USA, August 1–5, 2004.
Figure S4 from HIF2α-Targeted RNAi Therapeutic Inhibits Clear Cell Renal Cell Carcinoma (2023)

&lt;p&gt;In vivo trigger screen&lt;/p&gt;
An Analysis of Regulatory T-Cell and Th-17 Cell Dynamics during Cytomegalovirus Replication in Solid Organ Transplant Recipients (2012)

This study provides novel insights into T-regs and Th-17 subpopulations during CMV-replication after transplantation. These preliminary data suggest that measurement of CMV-specific CD4(+) T-cells together with T-regs has value in predicting spontaneous clearance of viremia and relapse.
Mantle Zone and Germinal Center B cells Respond to Different Activation Signals (1985)

The cross-linking of surface immunoglobulin on resting B lymphocytes by antigen or by anti-Ig antibody leads to proliferation and differentiation to plasma cells (1,2). Helper T cells provide growth and differentiation factors distinct from interleukin 2 (IL-2) that contribute to B cell proliferation (3,4). The proliferation and differentiation process involves multiple steps, including first activation by Ig or antigen. This causes a rapid increase in cell size and an elevation of levels of surface la antigens (5,6). These changes result from depolarization of the B cell plasma membrane (7) and can occur without B cell proliferation using low levels of anti-Ig, or using phorbol diesters (8). Anti-Ig activation of B cells also causes expression of receptors for a T cell factor(s) (9). Cells in this stage can proliferate in response to T cell factors alone and have been termed “preactivated” B cells (10,11). The preactivated cells constitute as many as 20% of peripheral blood B cells (12), are IgD−, proliferate in response to pokeweed mitogen (PWM) and are less dense than resting B cells (10,13).
Bioenergetic protection of failing atrial and ventricular myocardium by vasopeptidase inhibitor omapatrilat (2005)

Deficient bioenergetic signaling contributes to myocardial dysfunction and electrical instability in both atrial and ventricular cardiac chambers. Yet, approaches capable to prevent metabolic distress are only partially established. Here, in a canine model of tachycardia-induced congestive heart failure, we compared atrial and ventricular bioenergetics and tested the efficacy of metabolic rescue with the vasopeptidase inhibitor omapatrilat. Despite intrinsic differences in energy metabolism, failing atria and ventricles demonstrated profound bioenergetic deficiency with reduced ATP and creatine phosphate levels and compromised adenylate kinase and creatine kinase catalysis. Depressed phosphotransfer enzyme activities correlated with reduced tissue ATP levels, whereas creatine phosphate inversely related with atrial and ventricular load. Chronic treatment with omapatrilat maintained myocardial ATP, the high-energy currency, and protected adenylate and creatine kinase phosphotransfer capacity. Omapatrilat-induced bioenergetic protection was associated with maintained atrial and ventricular structural integrity, albeit without full recovery of the creatine phosphate pool. Thus therapy with omapatrilat demonstrates the benefit in protecting phosphotransfer enzyme activities and in preventing impairment of atrial and ventricular bioenergetics in heart failure.
Undetection error probability of linear and alternating-phase codes over the timing error channel (2004)

We develop a channel model for errors originated from over-aggressive operation of a communication link. Such a situation arises in the context of on-chip self-calibrating communication, where a link controller has to determine adaptively the operating voltage and frequency. Based on this channel model, we derive an analytical expression for the undetection error probability of linear codes, and alternating-phase codes, the latter being an extension of the former.
Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering (2022)

A conventional antibody targeting a soluble antigen in circulation typically requires a huge dosage and frequent intravenous administration to neutralize the antigen. This is because antigen degradation is reduced by the formation of antigen-antibody immune complexes, which escape from lysosomal degradation using neonatal Fc receptor (FcRn)-mediated recycling. To address this, we developed an antigen-sweeping antibody that combines pH-dependent antigen binding and Fc engineering to enhance Fc receptor binding. The sweeping antibody actively eliminates the plasma antigens by increasing the cellular uptake of the immune complex and dissociating the antigens in the acidic endosome for degradation. Strong antigen sweeping can reduce the dosage, potentially achieve higher efficacy, and expand the scope of antigen space available for targeting by antibodies. In this study, to further improve the sweeping efficacy, we developed a novel antibody Fc variant by enhancing Fcγ receptor IIb (FcγRIIb) binding and modulating charge characteristics for increased cellular uptake of the immune complex, together with enhancing FcRn binding for efficient salvage of the antigen-free antibodies. Our Fc variant achieved strong antigen sweeping in cynomolgus monkeys with antibody pharmacokinetics comparable to a wild-type human IgG<sub>1</sub> antibody. The positive-charge substitutions enhanced uptake of the immune complex by FcγRIIb-expressing cells in vitro, which was completely inhibited by an anti-FcγRIIb antibody. This suggests that the strong in vivo sweeping efficacy improved by the charge engineering is more likely achieved by FcγRIIb-dependent uptake of the immune complex rather than nonspecific uptake. We expect this novel Fc engineering can maximize the antigen sweeping efficacy even in humans and create novel therapeutic antibodies that meet unmet medical needs for patients.
Wake vortex detection, prediction and decision support toolsNew challenge for airports to increase capacity and safety (2013)

15 REE N°3/2013 Introduction A ircraft creates wake vortices in different ﬂying phases. To avoid jeopardizing ﬂight safety by wake vortices encounters, time/distance sepa- rations have been conservatively increased, thus restricting runway capacity. The concern is higher during taking off and landing phases, as aircraft are less easy to ma- neuver. These vortices usually dissipate quickly (decay due to air turbulence or transport by cross-wind), but most airports operate for the safest scenario, which means that the interval between aircraft taking off or landing often amounts to several minutes. However, with the aid of accurate wind data and pre- cise measurements of wake vortices, more efﬁcient intervals can be set, particularly when weather conditions are stable. Depending on trafﬁc volume, these adjustments can generate capacity gains which have major commercial beneﬁts. Wake vortices are a natural by-product of lift generated by aircraft and can be considered as two horizontal tornadoes trailing behind the aircraft. A trailing aircraft exposed to the wake vortex turbulence of a lead aircraft can experience an Wake vortex detection, prediction and decision support t
Erste direkte Synthese von Corrolen aus Pyrrol (1999)

Die lösungsmittel- und katalysatorfreie Kondensation von Pyrrol und Aldehyden bietet einen äußerst einfachen Zugang zu neuartigen Corrolen [Gl. (1); Ar = C6F5, 2,6-F2C6H3, 2,6-Cl2C6H3]. Das Pentafluorphenyl-substituierte Produkt (Ar = C6F5) ist eine exzellente Vorstufe für andere Derivate, einschließlich eines ionischen, wasserlöslichen Corrols.
Asynchronous Signal Reception in OFDMA-PON-Uplink (2013)

We propose an OFDMA-PON receiver DSP structure that is tolerant to timing offsets of the multiplexed upstream signals. With this technique complex synchronization requirements of the PON can be avoided.
Use of a Designed Peptide Array To Infer Dissociation Trends for Nontryptic Peptides in Quadrupole Ion Trap and Quadrupole Time-of-Flight Mass Spectrometry (2007)

Observed peptide gas-phase fragmentation patterns are a complex function of many variables. To systematically probe this phenomenon, an array of 40 peptides was synthesized for study. The array of sequences was designed to hold certain variables (peptide length) constant and randomize or balance others (peptide amino acid distribution and position). A high-quality tandem mass spectrometry (MS/MS) data set was acquired for each peptide for all observed charge states on multiple MS instruments, quadrupole-time-of-flight and quadrupole ion trap. The data were analyzed as a function of total charge state and number of mobile protons. Previously known dissociation trends were observed, validating our approach. In addition, the general influence of basic amino acids on dissociation could be determined because, in contrast to the more widely studied tryptic peptides, the amino acids H, K, and R were positionally distributed. Interestingly, our results suggest that cleavage at all basic amino acids is suppressed when a mobile proton is available. Cleavage at H becomes favored only under conditions where a partially mobile proton is present, a caveat to the previously reported trend of enhanced cleavage at H. Finally, all acquired data were used as a benchmark to determine how well these sequences would have been identified in a database search using a common algorithm, Mascot.