gebhart/patrepeval huggingface dataset:
Lattice Partition Multiple Access: A New Method of Downlink Non-orthogonal Multiuser Transmissions (2016)

In this paper, we propose a new downlink non-orthogonal multiuser superposition transmission scheme for future 5G cellular networks, which we refer to as the lattice partition multiple access (LPMA). In this proposed design, the base station transmits multilevel lattice codes for multiple users. Each user's code level corresponds to a distinct prime and is weighted by a product of all distinct primes of the other users excluding its own. Due to the structural property of lattice codes, each user can cancel out the interference from the other code levels by using the modulo lattice operation in a successive/parallel manner. LPMA can overcome the drawback of non-orthogonal multiple access (NOMA), which arises when users have similar channel conditions. We demonstrate that the proposed LPMA shows a clear throughput enhancement over the current NOMA scheme.
Electrostatic ion-cyclotron waves in magnetospheric plasmas: non-local aspects. Memorandum report (1983)

The importance of the effect of the magnetic shear and the finite size of current channel on the electrostatic ion-cyclotron instability for the space plasmas is illustrated. A non-local treatment is used. When the channel width Lc, is larger than the shear length Ls, there is a large reduction in the growth rate along with a noteworthy reduction of the band of the unstable perpendicular wavelengths. For Lc < or = Ls/10 the growth rate is not much altered from its local value, however for Lc/pi i < or = 10 to the second power the growth rate starts falling below the local value and vanishes for Lc pi i. The non-local effects lead to enhanced coherence in the ion cyclotron waves.
Unusual origin of left vertebral artery from the arch of aorta: a case report. (2015)

The aortic arch is a continuation of the ascending aorta, being located in the superior mediastinum. Three branches, the brachiocephalic trunk, left common carotid artery and left subclavian artery usually branch from the aortic arch. These branches may branch from the beginning of the arch or the upper part of the ascending aorta by varying distances between them. The brachiocephalic trunk later divides into right common carotid artery and right subclavian artery. Variations in the branching pattern of the aortic arch range from differences in the distance between origins of different branches to number of branches [1, 2].In approximately 48 year old Indian male cadaver during routine dissection, we reported a variant of aortic arch branching pattern where the left vertebral artery arises from the arch of aorta in between the origin of the left common carotid artery and left subclavian artery whereas the right vertebral artery took its normal origin from right subclavian artery.The anatomic and morphologic variations of the left vertebral artery are significant for diagnostic, surgical procedures and vascular radiology in the head and neck region [3]. It is of clinical importance to know the origin and course of prevertebral segment of the vertebral artery in detail and being aware of the possible variations.
Diffractive Optics Modeling: Introduction (1995)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. G. Moharam, T. K. Gaylord, and J. R. Leger, "Diffractive Optics Modeling: Introduction," J. Opt. Soc. Am. A 12, 1026-1026 (1995) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Supplementary Table 2 from TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase (2023)

&lt;p&gt;PDF file, 72K, Candidate functional partners of TIG1 selected using DNA microarray analysis.&lt;/p&gt;
Anomalous behavior of the structural relaxation dispersion function of a carborane-containing siloxane (2010)

Broadband dielectric spectroscopic investigations of a vinyl-terminated carboranylenesiloxane, VCS, were performed at ambient and elevated pressures. At a constant structural relaxation time, results show that the structural relaxation dispersion function of VCS narrows with both increasing pressure and temperature. This narrowing is substantial in the case of pressurization and, consequently, the breakdown of the temperature-pressure superposition rule is observed. The interpretation of this breakdown is presented.
An Easy Access to Bicyclic Peptides with an Octahydro[2H]pyrazino[1,2-a]pyrazine Skeleton (1999)

A new route to octahydrospiro(cyclopropane-1,1′-[2H]-pyrazino[1,2-a]pyrazine)-3′,6′,9′-triones 12–15 has been developed. Michael additions of primary amines onto methyl 2-Me or tert-butyl 2-tBu 2-chloro-2-cyclopropylideneacetates, followed by DCC- or EDC-induced coupling with Boc- or FmocGlyOH, deprotection and cyclization led to α-amino esters 4a–c and chlorohexahydrodiazepinediones 5a–c, or in the case of 2-tBu to the α-amino ester 7 exclusively. This reaction sequence with (S)-BocPheOH and (S)-BocTrpOH diastereoselectively gave (3′R,5′S)-9a,b and (2′S,6′R)-11a,b as the main products. Further peptide coupling, deprotection and cyclization with 4a–c yielded octahydrospiro(cyclopropane-1,1′-[2H]pyrazino[1,2-a]pyrazine)-3′,6′,9′-triones (7′S,9a′S)-12a–d, (6a′S,11a′S)-12e, (7′S,9a′R)-13a–d and (6a′S,11a′R)-13e which were easily separated. The α-amino esters 9a,b yielded (4′S,9a′R)-14a (≡15a) and (4′S,9a′R)-14b (≡15b), (4′S,7′S,9a′R)-14c and (4′R*,7′S*,9a′S*)-15c. The formation of compounds with three stereogenic centers 14c and 15c was accompanied by partial racemization. The versatility of the reported reaction sequence is limited by the steric availability of the secondary amino group in the intermediates 4, 9 and 10, as well as in the Michael adducts formed from primary amines and 2-Me.
Single-cell time-series mapping of cell fate trajectories reveals an expanded developmental potential for human PSC-derived distal lung progenitors (2019)

Abstract Alveolar epithelial type 2 cells (AEC2s) are the facultative progenitors responsible for maintaining lung alveoli throughout life, yet are difficult to access from patients for biomedical research or lung regeneration applications. Here we engineer AEC2s from human induced pluripotent stem cells (iPSCs) in vitro and use single cell RNA sequencing (scRNA-seq) to profile the detailed kinetics of their differentiation over time. We focus on both the desired target cells as well as those that appear to diverge to alternative endodermal fates. By combining scRNA-seq with lentiviral barcoding to trace differentiating clones, we reveal the bifurcating cell fate trajectories followed as primordial lung progenitors differentiate into mature AEC2s. We define the global transcriptomic signatures of primary developing human AEC2s from fetal through adult stages in order to identify the subset of in vitro differentiating cells that appear to recapitulate the path of in vivo development. In addition, we develop computational methods based on Continuous State Hidden Markov Models (CSHMM) to identify the precise timing and type of signals, such as over-exuberant Wnt responses, that induce some early multipotent NKX2-1+ progenitors to lose lung fate as they clonally diverge into a variety of non-lung endodermal lineages. Finally, we find that this initial developmental plasticity is regulatable via Wnt modulation, and subsides over time, ultimately resulting in iPSC-derived AEC2s that exhibit a stable phenotype and nearly limitless self-renewal capacity in vitro. Our methods and computational approaches can be widely applied to study and control directed differentiation, producing an inexhaustible supply of mature lineages, exemplified here by the generation of AEC2s.
A 10Watts, X band GaN HEMT three-way Doherty amplifier based on a new symetrical topology. (2007)

International audience
The Convergent Route to Globular Dendritic Macromolecules: A Versatile Approach to Precisely Functionauzed Three-Dimensional Polymers and Novel Block Copolymers (1994)

The convergent growth approach to dendritic macromolecules is a versatile method for the preparation of globular molecules with highly controlled three-dimensional architectures. The method, inspired from a classical organic disconnection approach, starts growth of the globular dendrimer at what will become its chain-ends and proceeds toward what will become its center. The convergent growth has been applied to the preparation of a number of unconventional dendritic block copolymers as well as hybrid globular-linear copolymers that are not readily accessed by other routes. Control of the chemistry and the precise location of the chain-ends in convergent dendrimers is essential for the preparation of micellar, amphiphilic, dipolar, or other structures that may be useful in applications as varied as drug delivery and molecular devices.
SDN-enabled terahertz x-haul network (2021)

With the explosive data growth of user traffic in wireless communications, Terahertz (THz) frequency band is envisioned as a promising candidate to support ultrabroadband communications for beyond fifth generation (5G) networks. Software-based networking is being adopted in mobile communications to improve efficiency and reduce operational costs. This paper presents the design of a comprehensive SDN management architecture for joint optimization of radio and network resources. The proposed architecture obtains the most added value out of the use of THz technology integrated with software managed networking for mobile network beyond 5G. In this paper, leveraging optical concepts and photonic integration techniques for an ultra-broadband and ultra-wideband wireless system is presented.
IdleChat (2011)

Residential broadband links are characterized by low and variable upload capacity and large latencies, leading to poor video performance. Aggregating multiple backhaul links using 802.11 Access Points has been considered as a solution to increasing the backhaul capacity limit. In this paper, we revisit the problem of backhaul aggregation in the context of interactive applications. We present the IdleChat architecture that uses wireless connectivity to aggregate idle broadband connectivity in a neighborhood to overcome the limits of individual asymmetric broadband uplinks. In contrast to prior work, IdleChat aggregates in a traffic-aware manner, focussing specifically on low-latency, real-time link aggregation in support of interactive applications such as video chat. IdleChat schedules packets in a deadline-aware manner to improve interactivity. We evaluate IdleChat both in an experimental testbed in our lab and in a residential deployment. Our results show that use of IdleChat in existing deployments can improve video SNR by up to a factor of 10 db in the presence of a single neighboring AP. This results in video quality improvement from a MOS score of bad to excellent.
Susceptibility Discontinuity in Single CrystalC60 (1994)

Magnetization of a large single ${\mathrm{C}}_{60}$ crystal was measured as functions of applied field and temperature. At $T=260$ K, a discontinuity in susceptibility was observed. The relative change in total moment is 1.2%, independent of applied field to within experimental accuracy. This discontinuity is attributed to the change in the intramolecular geometry at the orientational order-disorder transition. This is the first experimental demonstration that the cooperative phase transition affects the magnetic susceptibility of a single molecule.
Prediction of Response to Temozolomide in Low‐Grade Glioma Patients Based on Tumor Size Dynamics and Genetic Characteristics (2015)

Both molecular profiling of tumors and longitudinal tumor size data modeling are relevant strategies to predict cancer patients' response to treatment. Herein we propose a model of tumor growth inhibition integrating a tumor's genetic characteristics (p53 mutation and 1p/19q codeletion) that successfully describes the time course of tumor size in patients with low-grade gliomas treated with first-line temozolomide chemotherapy. The model captures potential tumor progression under chemotherapy by accounting for the emergence of tissue resistance to treatment following prolonged exposure to temozolomide. Using information on individual tumors' genetic characteristics, in addition to early tumor size measurements, the model was able to predict the duration and magnitude of response, especially in those patients in whom repeated assessment of tumor response was obtained during the first 3 months of treatment. Combining longitudinal tumor size quantitative modeling with a tumor''s genetic characterization appears as a promising strategy to personalize treatments in patients with low-grade gliomas.
Pyromellitic Diimides: Minimal Cores for High Mobility n-Channel Transistor Semiconductors (2008)

Three pyromellitic diimides were synthesized in high yields by one conventional reaction between pyromellitic dianhydride and various amines. The films made from these pyromellitic diimides derivatives exhibit a mobility up to 0.079 cm2/(V.s). In addition, the on/off ratios of n-channel devices are as high as 1 000 000.
Diffusion Bonding of Similar and Dissimilar Titanium Alloys (2016)

TIMETAL®54M (Ti-5Al-4V-0.75Mo-0.5Fe) or Ti-54M is an alpha/beta titanium alloy developed by TIMET. Ti-54M sheets exhibit excellent superplasticity at low temperatures [1]. Therefore, it was of particular interest to evaluate diffusion bonding capability of this alloy at low temperatures as well. Lab scale diffusion couples of 38mm × 51mm were shielded with EB welding in vacuum and bonded using MTS machine. Three titanium alloys, Ti-54M, Ti-6Al-4V (Ti-64) and Ti-6Al-2Sn-4Zr-2Mo-0.1Si (Ti-6242S) were diffusion-bonded in a similar and dissimilar alloy combination by varying parameters such as pressure, temperature and time. The bonding interface area was observed using an optical microscope and the % bonding was measured. This paper will present the laboratory procedure for diffusion bonding and provides the results of such bonding for similar and dissimilar titanium alloys. Various metallurgical factors that influence % bonding will also be discussed.
An improved method of delivering a sclerosing agent for the treatment of malignant pleural effusion (2019)

This report describes using a novel talc foam delivery system for the treatment of MPE. In the LL/2 model, mice treated with the TF had better survival outcomes and less reduction of lung volume than mice treated with the standard of care TS. These data provide support for translational efforts to move talc foam from animal models into clinical trials.
Comparative studies of load balancing with control and optimization techniques (2005)

Load balancing is a widely used technique to optimizing distributed computing system performance. System response delays are reduced by equalizing the loads, such as adjusting memory pool sizes to balance disk access demands in a database management system. In this paper we formulate load balancing as a constrained optimization problem and investigate two load balancing controllers based on feedback control theory and optimization theory. We show the difference and equivalence between their design methods and criteria. Furthermore, our studies on a DB2 universal database server reveal their performance difference regarding to system noise and workload variations.
Regulatory T Cells Control Dendritic Cell/NK Cell Cross-Talk in Lymph Nodes at the Steady State by Inhibiting CD4+ Self-Reactive T Cells (2008)

Abstract The CD4+CD25+Foxp3+ regulatory T cells (Treg) play an important role in the control of peripheral tolerance by directly inhibiting conventional T cell proliferative and effector functions. However, the mechanisms by which Treg regulate the homeostasis of lymph nodes remain unclear. In this study, we show in a mouse model that Treg control two major checkpoints dictated by the interaction between self-reactive CD4+ T cells and resident dendritic cell (DC) in secondary lymphoid organs. First, Treg inhibit the production of CCR5 ligands, limiting the CCR5-dependent recruitment of DC in the lymph nodes. Second, Treg prevent the DC exposure of IL-15Rα, markedly interfering in the DC-mediated NK cell proliferation in vivo. Therefore, the DC/T cell autoreactivity leading to NK cell triggering could potentially be controlled by the coinhibition of both IL-15Rα and CCR5 in autoimmune disorders in which NK cells play a deleterious role.
Effect of rise/decay time on phase detection in lateralization (1980)

Experiments in lateralization were performed to evaluate the relative contribution of onset and phase cues in the integration of binaural signals. A 1-kHz signal was presented with interaural stimulus delays ranging from 0–100 μs, i.e., phase shifts of 0–360°. For a given value of delay, the leading signal was presented randomly to the right or left ear over a block of 100 trials, and the laterality of the resultant image was judged. The probability of a correct response was plotted as function of delay with rise time as a parameter. Particular attention was paid to the trade-off between phase and onset in the region of phase shifts from 180° to 360°. It was noted in particular, that the onset cue was eliminated only for rise times in excess of 500 ms, and that there were wide individual differences in the use of the two cues. [Work supported by Natural Sciences and Engineering Research Council, Canada.]
Impact of hyperhydration on the mortality risk in critically ill patients admitted in intensive care units: comparison between bioelectrical impedance vector analysis and cumulative fluid balance recording (2016)

The hydration status measured by BIVA seems to predict mortality risk in ICU patients better than the conventional method of fluid balance recording. Moreover, it appears to be safe, easy to use and adequate for bedside evaluation. Randomized clinical trials with an adequate sample size are needed to validate the diagnostic properties of BIVA in the goal-directed fluid management of critically ill patients in ICU.
Distinct metabolic programs in activated T cells: opportunities for selective immunomodulation (2012)

For several decades, it has been known that T-cell activation in vitro leads to increased glycolytic metabolism that fuels proliferation and effector function. Recently, this simple model has been complicated by the observation that different T-cell subsets differentially regulate fundamental metabolic pathways under the control of distinct molecular regulators. Although the majority of these data have been generated in vitro, several recent studies have documented the metabolism of T cells activated in vivo. Here, we review the recent data surrounding the differential regulation of metabolism by distinct T-cell subsets in vitro and in vivo and discuss how differential metabolic regulation might facilitate T-cell function vis-à-vis proliferation, survival, and energy production. We further discuss the important therapeutic implications of differential metabolism across T-cell subsets and review recent successes in exploiting lymphocyte metabolism to treat immune-mediated diseases.
Compiler and runtime support for running OpenMP programs on Pentium- and Itanium-architectures (2003)

Exploiting Thread-Level Parallelism (TLP) is a promising way to improve the performance of applications with the advent of general-purpose cost effective uni-processor and shared-memory multiprocessor systems. In this paper, we describe the OpenMP* implementation in the Intel/spl reg/ C++ and Fortran compilers for Intel platforms. We present our major design consideration and decisions in the Intel compiler for generating efficient multithreaded codes guided by OpenMP directives and pragmas. We describe several transformation phases in the compiler for the OpenMP* parallelization. In addition to compiler support, the OpenMP runtime library is a critical part of the Intel compiler. We present runtime techniques developed in the Intel OpenMP runtime library for exploiting thread-level parallelism as well as integrating the OpenMP support with other forms of threading termed as sibling parallelism. The performance results of a set of benchmarks show good speedups over the well-optimized serial code performance on Intel/spl reg/ Pentium- and Itanium-processor based systems.
Antioxidative Phenolic Compounds from Sage (Salvia officinalis) (1998)

Ten phenolic compounds were isolated from a butanol fraction of sage extracts. Their structures were determined by spectral methods (NMR, MS, IR). Among them, a novel compound, 4-hydroxyacetophenone-4-O-β-d-apiofuranosyl-(1→6)-O-β-d-glucopyranoside, was identified. Two test systems, DPPH free radical scavenging activity and radical cation ABTS•+ scavenging activity, were used to evaluate their antioxidant activity. The most active compounds were found to be rosmarinic acid and luteolin-7-O-β-glucopyranoside. Keywords: Sage; Salvia officinalis; phenolic compounds; antioxidant activity
Time-Resolved Measurement of the ATP-Dependent Motion of the Group II Chaperonin by Diffracted Electron Tracking (2018)

Previously, we demonstrated the ATP-dependent dynamics of a group II chaperonin at the single-molecule level by diffracted X-ray tracking (DXT). The disadvantage of DXT is that it requires a strong X-ray source and also perfect gold nano-crystals. To resolve this problem, we developed diffracted electron tracking (DET). Electron beams have scattering cross-sections that are approximately 1000 times larger than those of X-rays. Thus, DET enables us to perform super-accurate measurements of the time-resolved 3D motion of proteins labeled with commercially available gold nanorods using a scanning electron microscope. In this study, we compared DXT and DET using the group II chaperonin from <i>Methanococcus maripaludis</i> (MmCpn) as a model protein. In DET, the samples are prepared in an environmental cell (EC). To reduce the electron beam-induced protein damage, we immobilized MmCpn on the bottom of the EC to expose gold nanorods close to the carbon thin film. The sample setup worked well, and the motions of gold nanorods were clearly traced. Compared with the results of DXT, the mobility in DET was significantly higher, which is probably due to the difference in the method for immobilization. In DET, MmCpn was immobilized on a film of triacetyl cellulose. Whereas proteins are directly attached on the surface of solid support in DXT. Therefore, MmCpn could move relatively freely in DET. DET will be a state-of-the-art technology for analyzing protein dynamics.