gebhart/patrepeval huggingface dataset:
Optimal Power Sharing Speed Compensation in On-road Wireless EV Charging Systems (2023)

Dynamic wireless charging of electric vehicles (EV) is an emerging technology with the potential to address range anxiety and reduce the size of batteries or provide charge-sustaining operation. Charging demand for dynamic wireless charging systems (DWCS) varies greatly in response to location-specific traffic behaviors including the number and speed of vehicles. This paper highlights the potential reduction of load variation with speed compensation and simulates opportunities to maximize the number of cars charged concurrently through “power sharing” or altering power output to slower cars while maintaining a maximum delivered energy. An improved sub-minute model for synthetic traffic is proposed to effectively model DWCS load on high speed roadways and a power electronics model is created based on an existing prototype developed by ORNL to investigate the potential for power sharing. Reductions in the average speed of traffic can greatly increase instantaneous DWCS load by as much as 26%, complicating capacity sizing. Parametric studies with a LCC-S power electronics model shows feasible power reduction of more than 20%, while maintaining a maximum achievable efficiency greater than 90%. Speed compensation on a roadway with large speed variation can reduce average power expected by 21% and increase the maximum number of cars charged simultaneously by 30%. The application of power sharing may significantly reduce load variability due to speed, allow for increased car hosting capability, and guarantee a maximum energy delivered.
Highly Consistent, Fully Representative mRNA-Seq Libraries from ten Nanograms of Total RNA (2010)

Preparation of an Illumina sequencing library for gene expression analysis (mRNA-Seq) requires microgram amounts of starting total RNA or PCR-based amplification. Here we describe a protocol based on T7 linear RNA amplification that does not introduce significant bias, requires only 10 ng total RNA, and generates a directional, fully representative, whole-transcript mRNA-Seq Illumina library that is highly consistent across over three orders of magnitude of input RNA.
A corresponding states principle for physisorption and deviations for quantum fluids (2008)

The principle of corresponding states has long been observed to be valid for simple fluids in the bulk state. It has recently been proposed that fluids adsorbed in a microporous sorbent also follow a form of corresponding states [D.F. Quinn, Carbon 40, 2767 (2002)]. It was observed that adsorption isotherms for several different adsorbates follow near-universal behaviour when plotted at the reduced temperature 2.36 as a function of reduced pressures, where the critical temperature and pressure are used as the reducing parameters. Significantly, Quinn noted that hydrogen manifestly does not follow the trends of the other fluids, showing much higher adsorption than any other fluid studied; this was ascribed to hydrogen being able to adsorb in very narrow pores not accessible to other adsorbates. It is shown in the current work that the anomalous behaviour of hydrogen can be described entirely by quantum effects and the relative strength of the fluid–fluid and solid–fluid potentials. Analytical and simulation methods are used to investigate the adsorption of various gases within slit and cylindrical pores. For large pore sizes, accessible to all adsorbates, corresponding states behaviour occurs for classical gases, with deviations observed for quantum gases, in agreement with experimental observations. In contrast, size-dependent selectivity (sieving) is found in small pores.
Tunable Microwave Single-Bandpass Photonic Filter Based on Amplified Mems-Based Gires–Tournois Interferometer (2020)

We demonstrate a compact microelectromechanical systems based tunable single bandpass microwave photonic filter (MPF). A MEMS gold-platted micro-mirror facing cleaved optical fiber forms a tunable miniature Gires-Tournois interferometer (GTI). The micro-mirror was fabricated by Deep Reactive Ion Etching (DRIE) on silicon on insulator (SOI) wafer. A semiconductor optical amplifier (SOA) is employed simultaneously as a source of a broad optical spectrum and as an optical amplifier. A chirped-fiber Bragg grating is used as a dispersive delay line to provide a time delay to each wavelength slice. The simulation and experimental results are in good agreement showing a linear variation of the MPF center frequency with the separation between the micro-mirror and the fiber facet. The measured tuning range and tuning resolution are 1.3 to 2.5 GHz and 5.85 MHz/μm, respectively. The measured value of the stopband attenuation is more than 20 dB. The maximum value of the 3-dB bandwidth is 258 MHz.
Tumor specific CTL therapy for advanced cancer and development for cancer vaccine. (1999)

It was clarified that tumor-specific CTL therapy as multidisciplinary treatment is clinically valuable, especially in terms of quality of life. For developing the new strategy against cancer, CEA specific cancer vaccine trials have just started.
Ultrafast Charge Generation in an Organic Bilayer Film (2014)

The dynamics of charge generation in a high performing molecular photovoltaic system, p-SIDT(FBTTh2)2 (see Figure 1 ) is studied with transient absorption. The optimized bulk heterojunction material shows behavior observed in many other systems; the majority of charges are generated at short time scales (<150 fs), and a slower contribution from incoherently diffusing excitons is observed at low pump fluence. In a separate experiment, the role of bulk heterojunction material morphology on the process of ultrafast charge generation was investigated with bilayers made with solution processed donor molecules on a photopolymerized C60 layer. The majority of carriers are again produced at short time scales, ruling out the idea that subpicosecond charge generation can be understood wholly in terms of localized excitons. We evaluate possible causes of this behavior and propose that the excited state is highly delocalized on short time scales, providing ample probability density at the charge generating interface.
Self-consistent projection operator theory (2016)

This thesis develops the self-consistent projection operator theory which generalizes the concepts of open systems theory to settings where a dynamically evolving environment has to be taken into account. We illustrate the usability of our theory for a broad range of applications by testing its performance for the determination of stationary states and transient time evolutions, both, for the models of nonlinear quantum optics and driven-dissipative many body lattice systems.
Induction of Apoptosis and Inhibition of NO Production by Piceatannol in Human Lung Cancer A549 Cells (2012)

Resveratrol 유도체의 일종으로 stilbene계열 물질인 piceatannol은 암세포의 증식을 억제하고 apoptosis를 유발하는 것으로 알려져 있다. 본 연구에서는 A549 인체 폐암세포를 대상으로 piceatannol에 의한 암세포 증식억제와 연관된 부가적인 기전연구를 실시하였다. 본 연구의 결과에서 piceatannol이 A549 세포에서 extrinsic 및 intrinsic pathway의 동시 활성을 통하여 apoptosis를 유발하였음을 Fas/FasL의 발현 증가와 caspase-8 및 -9의 활성증가로 확인하였다. 또한 piceatannol은 caspase-3의 활성을 증가시켰으며, caspase-3의 다양한 표적 단백질들의 발현 감소가 동반되었다. 아울러 piceatannol에 의한 apoptosis 유발 과정은 iNOS의 발현 감소에 의한 NO의 생성 억제와도 연관성이 있었다. Piceatannol (trans-3,4,3',5'-tetrahydroxystilbene), a natural stilbene, is an analogue of resveratrol. Although recent experimental data have revealed the health benefit potency of piceatannol, the molecular mechanisms underlying the anti-cancer activity have not yet been studied in detail. In the present study, the further possible mechanisms by which piceatannol exerts its pro-apoptotic action in cultured human lung cancer A549 cells were investigated. Exposure of A549 cells to piceatannol resulted in growth inhibition and induction of apoptosis. Apoptosis induction of A549 cells by piceatannol showed correlation with proteolytic activation of caspase-3, -8, and -9, and concomitant degradation of activated caspase-3 target proteins such as poly (ADP-ribose) polymerase, phospholipase C-<TEX>${\gamma}1$</TEX>, <TEX>${\beta}$</TEX>-catenin, and Inhibitor caspase-activated DNase. The increase in apoptosis by piceatannol treatment was also associated with an increase of pro-apoptotic Bax expression and decrease of anti-apoptotic Bcl-2 and Bcl-xL expression, and caused down-regulation of the inhibitor of apoptosis protein family members and up-regulation of Fas and Fas legend. In addition, piceatannol treatment markedly inhibited the expression of mRNA and proteins of inducible nitric oxide (NO) synthase, and the levels of NO production were progressively down-regulated by piceatannol treatment in a dose-dependent fashion. The results indicate that piceatannol may have therapeutic potential against human gastric cancer cells.
Horizontal Auto-Scaling in Edge Computing Environment using Online Machine Learning (2021)

A major challenge in edge computing platforms for container-based applications is dealing with the dynamic workload. At certain times, the resources previously allocated to a given container may not be adequate for a substantial increase in processing requests. This paper proposes an online machine learning auto-scaling approach for applications running at the network edge. The auto-scaling follows the MAPE-K control loop architectural style to dynamically adjust the number of containers in response to workload changes. The approach was designed for scenarios at the edge of the network where the behavior of the data is unknown beforehand. We designed a hybrid auto-scaling mechanism that behaves reactively while a prediction online machine learning model is continuously trained. When the prediction model reaches a desirable performance, the auto-scaling behaves proactively using predictions to anticipate scaling actions. The evaluations have demonstrated the feasibility of the architecture. Compared with proactive and reactive auto-scaling, it achieved the best results, decreasing the scaling actions, preventing insufficient provision situations, and assuring the meeting of QoS requirements.
An analysis of a service system supporting IBM's global service delivery (2009)

The world economy continues to evolve away from the traditional producer-consumer roles prevalent in the industrial era, towards more dynamical, collaborative business relationships characteristic of the emerging global services economy. New challenges are emerging for businesses engaged in service delivery, particularly concerning process normalization and cost estimation. Service standardization is being addressed at IBM through careful analysis of historical service deals and the development of ldquobest practicerdquo standards for service solutions. The Solution Definition Manager (SDM) is a platform developed at IBM through a close collaboration among research and business representatives, designed to support the flexible creation of global service solutions within standards, as well as subsequent cost estimation and pricing of those solutions at fine level of granularity. In this paper, the SDM is discussed in terms of how and why it is being developed as well as the business transformation it represents. An analysis is presented of how research and business groups within IBM have co-created value by transforming internal processes, and how the SDM in turn allows IBM to be a better partner for value co-production while delivering services to external clients.
From non-deterministic to probabilistic planning with the help of statistical relational learning (2009)

To make real-time measurements of glutamate in the ventromedial globus pallidus (vGP) in rats during free ingestive behavior, a recently developed dialysis biosensor was employed. The glutamate level in the vGP increased in response to intraoral infusions of various fluids and voluntary ingestion of food pellets. Palatable fluids evoked greater responses than unpalatable fluids did, suggesting that glutamate in the vGP is involved in ingestive behavior.
Antagonistic Regulation of Growth and Immunity by the Arabidopsis Basic Helix-Loop-Helix Transcription Factor HOMOLOG OF BRASSINOSTEROID ENHANCED EXPRESSION2 INTERACTING WITH INCREASED LEAF INCLINATION1 BINDING bHLH1 (2014)

Plants need to finely balance resources allocated to growth and immunity to achieve optimal fitness. A tradeoff between pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and brassinosteroid (BR)-mediated growth was recently reported, but more information about the underlying mechanisms is needed. Here, we identify the basic helix-loop-helix (bHLH) transcription factor homolog of brassinosteroid enhanced expression2 interacting with IBH1 (HBI1) as a negative regulator of PTI signaling in Arabidopsis (Arabidopsis thaliana). HBI1 expression is down-regulated in response to different PAMPs. HBI1 overexpression leads to reduced PAMP-triggered responses. This inhibition correlates with reduced steady-state expression of immune marker genes, leading to increased susceptibility to the bacterium Pseudomonas syringae. Overexpression of the HBI1-related bHLHs brassinosteroid enhanced expression2 (BEE2) and cryptochrome-interacting bHLH (CIB1) partially inhibits immunity, indicating that BEE2 and CIB1 may act redundantly with HBI1. In contrast to its expression pattern upon PAMP treatment, HBI1 expression is enhanced by BR treatment. Also, HBI1-overexpressing plants are hyperresponsive to BR and more resistant to the BR biosynthetic inhibitor brassinazole. HBI1 is nucleus localized, and a mutation in a conserved leucine residue within the first helix of the protein interaction domain impairs its function in BR signaling. Interestingly, HBI1 interacts with several inhibitory atypical bHLHs, which likely keep HBI1 under negative control. Hence, HBI1 is a positive regulator of BR-triggered responses, and the negative effect of PTI is likely due to the antagonism between BR and PTI signaling. This study identifies a novel component involved in the complex tradeoff between innate immunity and BR-regulated growth.
Winds of change (2014)

The artwork was created for and contributed to the launch of ArtCity. ArtCity is an Arts Council England funded programme of work initiated by B Arts in Stoke on Trent. This is a 'cultural mapping project that will enable us to talk to artists and organisations across the city; in marketing and communications; and in developing links with artists and organisations beyond the city who could create work in Stoke'. (Words taken from project launch web page http://www.b-arts.org.uk/artcity-launches-in-style-on-wednesday/)
Editorial Board Focus – February 2007 (2007)

From our panel of expert Editorial Board members, an update on the developments and activities ongoing in thier laboratories and institutions, as well as recommendations of other groups whose work is of considerable interest to the readers of EOBT.
Plasma processes applied to SiO2 cryo-atomic layer etching (2019)

International audience
Extraction of Airways with Probabilistic State-space Models and Bayesian Smoothing (2017)

Segmenting tree structures is common in several image processing applications. In medical image analysis, reliable segmentations of airways, vessels, neurons and other tree structures can enable important clinical applications. We present a framework for tracking tree structures comprising of elongated branches using probabilistic state-space models and Bayesian smoothing. Unlike most existing methods that proceed with sequential tracking of branches, we present an exploratory method, that is less sensitive to local anomalies in the data due to acquisition noise and/or interfering structures. The evolution of individual branches is modelled using a process model and the observed data is incorporated into the update step of the Bayesian smoother using a measurement model that is based on a multi-scale blob detector. Bayesian smoothing is performed using the RTS (Rauch-Tung-Striebel) smoother, which provides Gaussian density estimates of branch states at each tracking step. We select likely branch seed points automatically based on the response of the blob detection and track from all such seed points using the RTS smoother. We use covariance of the marginal posterior density estimated for each branch to discriminate false positive and true positive branches. The method is evaluated on 3D chest CT scans to track airways. We show that the presented method results in additional branches compared to a baseline method based on region growing on probability images.
Switching Luminescent Properties in Osmium‐Based β‐Diketonate Complexes (2005)

Luminescent complexes: Through the design and synthesis of a series of new osmium-based β-diketonate carbonyl complexes (see picture; MLCT=metal-to-ligand charge transfer, kisc=intersystem crossing constant), a remarkable aromatic tunable fluorescence/phosphorescence ratio was explored. The relative luminescent efficiencies and associated dynamics were evaluated. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2267/2005/z500252_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
MUC1 vaccines and breast cancer (2000)

Breast cancer is the most common malignancy in women in the ‘developed’ world, with the number of new cases per year in the UK and USA being 34000 and 180000, respectively. Breast cancer is rare below the age of 30 but the incidence increases up to the age of 50. Beyond the age of 50, the incidence continues to rise but more slowly compared with premenopausal women. Although the incidence of breast cancer is increasing, recent data suggest that the mortality rate is decreasing. Nevertheless, with a death rate of 20 to 25 per 100000 in the West and a prevalence over three times the incidence, breast cancer continues to be a significant public health problem. Factors conferring an increased risk of breast cancer include mutations in the breast cancer susceptibility genes BRCA-1 and BRCA-2. While mutations in these genes account for the majority of familial breast cancers, they account for only 5 to 10% of all breast cancers. Other factors conferring increased risk include the presence of atypical hyperplasia and carcinoma in situ (cytologically malignant cells confined within a duct or lobule). Obesity, high alcohol consumption, prolonged use of oestrogens and previous radiotherapy to the breast are thought to confer an increase in risk of less than twice the background risk.
Reversing the Irreversible (1989)

Chronic obstructive pulmonary disease, also known as chronic airway obstruction, is a common disease. Exacerbations of this disorder accounted for more than 3.5 million hospital days in the United States in 1985.1 Not only is the disease common, but considerable resources are devoted to its treatment. One of every 60 prescriptions written in the United States in 1987 was written to treat chronic obstructive pulmonary disease.2 Is this treatment well directed? In contrast to the highly labile airways found in asthma, the obstruction in chronic obstructive pulmonary disease does not respond to the short-term administration of bronchodilator medications. As a . . .
Use of Intravenous Valproate in Three Pediatric Patients with Nonconvulsive or Convulsive Status Epilepticus (1999)

A 20 mg/kg loading dose should produce a concentration after the bolus dose of approximately 75 mg/L. Initial infusion should consider hepatic induction (noninduced = 1 mg/kg/h, polyanticonvulsant therapy = 2 mg/kg/h, and high-dose pentobarbital = 4 mg/kg/h). Adjustments should be based on response and serum concentrations.
DNA methylation profiling of the X chromosome reveals an aberrant demethylation on CXCR3 promoter in primary biliary cirrhosis (2015)

Our data provides a set of genes with epigenetic alteration likely to be indicators of autoimmunity and emphasizes the role of CXCR3 in the natural history of PBC.
Electrokinetic Remediation Technique: An Integrated Approach to Finding New Strategies for Restoration of Saline Soil and to Control Seawater Intrusion (2014)

Abstract Many applications of electrokinetic remediation have focused on the removal of heavy metals. However, the application of electrokinetic technology in salt removal from contaminated soils and groundwater has not been extensively explored. Given the current global challenge and the impact of soil and groundwater salinity, it is tempting to suggest that the research community should apply this technology to generate in‐depth knowledge for determining the feasibility and efficiency of electrokinetic remediation in salt removal, particularly in addressing seawater intrusion in coastal aquifers, which is creating growing challenges in the freshwater supply, mainly in coastal and arid regions, in view of growing populations, economic and industrial growth, and climate change. This Review shows that there is a need to begin formulating a knowledge base about categories of materials, efficiencies, and limitations. Furthermore, the viability of this technology in the real field suggests a need to gain more insight into electrokinetic applications in this area. The versatility of electrokinetic remediation in different settings is demonstrated in this Review, as is its capability to address diverse remediation challenges. The available literature is critically assessed; novel and improved electrokinetic remediation and the important trends in this field are outlined. The Review aims to summarize the evolution and current status of electrokinetic remediation research with a view of starting a debate around the possibility of applying it as a pretreatment mechanism to control seawater intrusion.
Supplementary Data from WWOX and p53 Dysregulation Synergize to Drive the Development of Osteosarcoma (2023)

&lt;p&gt;Supplementary Methods, Figures and Tables&lt;/p&gt;
<title>Position measurement of high-energy e-beams for pattern placement improvement</title> (1996)

We have developed a technique based on use of a novel e-beam detector to enhance pattern placement accuracy of high-performance e-beam tools in the patterning of membrane masks. The detector consists of a reverse biased Schottky diode whose area coincides with that of the membrane, and which is placed immediately behind the membrane/-absorber/resist multilayer. An accurately patterned absorber overlayer covers the detector surface. The overlayer absorbs a fraction of the incident electrons, modulating the detector signal as the beam passes over the membrane. We have studied and modeled the performance of prototype detectors covered with 16 micrometers period gratings over an incident energy range of 5-50 keV. The combination of Schottky diode and patterned overlayer has been used to improve electron scattering models. We have observed excellent SNR with a 40 nC/cm<SUP>2</SUP> dose at 50 kV, and spatial resolution better than 0.1 micrometers of a beam transmitted through a membrane. More accurate position information can be obtained by taking a Fourier transform of the diode current waveform created as the incident beam traverses several grating periods. In a poor operating environment, we have observed phase accuracy in 100 micrometers fields of +/- 4 degrees. We have developed an algorithm capable of processing pattern-based data sets at high speeds and low information storage requirements. This technique can be easily implemented with little overhead and little modification of existing systems.