gebhart/patrepeval huggingface dataset:
HMG-Co A Reductase Inhibitors in the Treatment of Cardiovascular Diseases: Stabilization of Coronary Artery Plaque (2002)

3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are greatly contributed to the treatment of hypercholesterolemia, and constitute an important part of comprehensive strategies for the treatment of cardiovascular disease in the 21st century. Particularly, a strategy for preventing acute coronary syndrome (ACS), the most important complication of hyperlipidemia, is urgently needed. Recent research has revealed a new mechanism of prevention of coronary heart disease by statins: they not only lowered cholesterol level as previously reported, but also contribute directly to plaque stabilization. Among many statins recently marketed, some act directly onto the blood vessel wall to stabilize plaques already formed (so-called vascular statins), while statins are originally classified as chemical or non-chemical. At the same time, reports on pleiotropic activities of statins, including improvement of osteoporosis, have accumulated to suggest an extended role of statins, not merely as a hypolipidemic agent but also possibly an anti-arteriosclerotic/anti-aging drug. This article reviews the direct action of statins on the blood vessel wall, with reference to classification of statins based on difference in action on the blood vessel wall (hepatic statins vs. vascular statins).
Cooling System Design (2016)

No AccessInjection Mold Design EngineeringApr 2016Cooling System DesignDavid O. KazmerDavid O. Kazmerhttps://doi.org/10.3139/9781569905715.009SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2016Pages: 243-290Print ISBN: 978-1-56990-570-8eISBN: 978-1-56990-571-5 Copyright & Permissions© 2016 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Effect of Mechanical Deformation on in Vitro Calcification of Segmented Polyurethane (1994)

To investigate why calcification is accelerated by mechanical flexure,&#13;\nin vitro calcification of segmented polyurethane (SPU) under static elongation and&#13;\ndynamic mechanical flexure was performed. After the calcification period, the amount&#13;\nof calcium deposition was increased by elongation, but the amount of calcium&#13;\ndeposition per unit area of the elongated surface was relatively smaller as compared&#13;\nto that of the severe flexing area. Although the surface calcium concentration of the&#13;\nelongated SPU was relatively smaller than the flexed area, there was the increase of&#13;\nsurface area by the elongation. The total amount of deposited calcium on the elongated&#13;\nSPU was increased as it is reduced to the original surface area. Therefore, the&#13;\nresults reveal that certain changes of surface properties by the Mechanical deformation&#13;\naccelerate the calcium deposition onto the surface and the enlargement of&#13;\nsurface area by the mechanical deformation results in the heavy calcification of the&#13;\nsevere flexing area in the SPU.
Fractal Features Combined with Local Phase Information in Texture Analysis (2019)

This paper concerns processing, analysis and classification of fully-textured images, which contain both natural stochastic texture (NST) and structured information (SI). Whereas the fractal attributes of Gaussianity and self-similarity, that characterize purely NST, are fully represented by the spatial spectrum, and the corresponding spatial phase of the NST is random, the structural, edge-and-curve-type, information is mostly represented by the local spatial phase. We therefore decompose textured images into two layers, corresponding to the NST and SI, respectively. We show that the extent to which the texture obeys the fractal property of self-similarity, can be assessed by the mutual information that exists between scales. The phase of this layer, in the spatial Fourier domain, is random and exhibit approximately uniform distribution. We confirm this random behavior using the Kolmagorov-Smirnov hypothesis testing framework. We proceed to construct a classification space that combines features/dimensions that characterize the two layers of the stochastic (fBm-type spectrum) and deterministic (phase) attributes of partial spatial information, and address the implementation of this space in classification of fully-textured images encountered in modeling and analysis of images in various fields by providing an example.
Antibiotics from basidiomycetes. X. Scorodonin, a new antibacterial and antifungal metabolite from Marasmius scorodonius (Fr.) Fr. (1980)

Scorodonin (1), a novel biologically active metabolite, was isolated from submerged cultures of the mushroom Marasmius scorodonius (FR.) FR. Its structure has been determined by chemical and physical methods. The antibiotic inhibits the growth of bacteria, yeasts, and filamentous fungi. In cells of the ascitic form of EHRLICH carcinoma the incorporation of thymidine and uridine into DNA and RNA is strongly inhibited by scorodonin whereas the incorporation of leucine into protein is not affected.
Les zéolithes, nouveaux agents de synergie dans les systèmes intumescents : compréhension des mécanismes de protection du polyéthylène et de ses copolymères (1993)

L'objectif de ce travail est l'ignifugation des polyethylenes et de ses copolymeres a l'aide de systemes retardants de flamme developpant un phenomene d'intumescence dans les conditions du feu. L'association de zeolithes comme agents de synergie avec le systeme intumescent polyphosphate d'ammonium (app) pentaerythritol (per) met en evidence une amelioration tres importante des proprietes retard au feu. L'etude comparative de systemes app/per-zeolithes et app-per : aluminosilicate amorphe montre par ailleurs, que l'on doit utiliser une zeolithe a rapport si/al faible et avoir un aluminosilicate a reseau zeolithique pour obtenir les performances optimales. La comprehension des mecanismes d'action de la zeolithe est conduite avec une formulation ethylene-acrylate de butyle-anhydride maleique (lram3,5)-app/per-zeolithe du type 4a(si/al=1). La caracterisation mas-rmn #2#7al et #2#9si montre que la zeolithe est detruite par l'app pour former des alumino- et silicophosphates. Ces especes stabilisent des chainons polyethyleniques sous forme d'esters de phosphoaluminosilicates organiques qui limite la depolymerisation et donc la formation de petites molecules inflammables. Ces esters empechent le developpement des structures polyaromatiques condensees. Les chainons forment des ponts entre les polyaromatiques qui donnent de bonnes proprietes mecaniques au revetement intumescent. Par consequent, au-dela de la protection par un processus chimique, la presence des chaines polyethyleniques assure une souplesse au materiau intumescent qui lui permet dans les conditions du feu, une bonne accommodation des contraintes et donc, un retard a la creation et propagation de fissures
The Photopolymer Science and Technology Award (2015)

The Photopolymer Science and Technology Award No.151100, the Outstanding Achievement Award 2015, was presented to Christopher Kemper Ober (Cornell University) for his outstanding achievements in photopolymer science and technology, “Development of new advanced photoresist for microelectronics”
Redefining Protein Interfaces within Protein Single Crystals with DNA (2021)

Proteins are exquisite nanoscale building blocks: molecularly pure, chemically addressable, and inherently selective for their evolved function. The organization of proteins into single crystals with high positional, orientational, and translational order results in materials where the location of every atom can be known. However, controlling the organization of proteins is challenging due to the myriad interactions that define protein interfaces within native single crystals. Recently, we discovered that introducing a single DNA-DNA interaction between protein surfaces leads to changes in the packing of proteins within single crystals and the protein-protein interactions (PPIs) that arise. However, modifying specific PPIs to effect deliberate changes to protein packing is an unmet challenge. In this work, we hypothesized that disrupting and replacing a highly conserved PPI with a DNA-DNA interaction would enable protein packing to be modulated by exploiting the programmability of the introduced oligonucleotides. Using concanavalin A (ConA) as a model protein, we circumvent potentially deleterious mutagenesis and exploit the selective binding of ConA toward mannose to noncovalently attach DNA to the protein surface. We show that DNA association eliminates the major PPI responsible for crystallization of native ConA, thereby allowing subtle changes to DNA design (length, complementarity, and attachment position) to program distinct changes to ConA packing, including the realization of three novel crystal structures and the deliberate expansion of ConA packing along a single crystallographic axis. These findings significantly enhance our understanding of how DNA can supersede native PPIs to program protein packing within ordered materials.
Referral Patterns, Diagnosis, and Disease Management of Patients With Axial Spondyloarthritis (2014)

Referral patterns, diagnosis, and disease management for axial SpA were similar among WE, North America, and RoW rheumatologists and in academic/community practices, although more WE and RoW rheumatologists referred to Assessment of SpondyloArthritis International Society criteria in clinical practice. Disease-modifying antirheumatic drugs were commonly prescribed for axial SpA patients, although it was unclear whether these were prescribed for axial or peripheral symptoms.
Effect of Ultrasonic Vibration on Fluid‐to‐Particle Convective Heat Transfer Coefficients (1989)

ABSTRACT Studies were conducted to determine the potential of ultrasonic energy as a heat transfer enhancing agent in sterilization applications. Metal transducer particles were immersed in warm liquids with and without sonic agitation, and temperature histories were recorded. Convective heat transfer coefficients were calculated from the solution to the lumped convective heat transfer equation. Results indicate that fluid‐to‐particle heat transfer was significantly enhanced by the use of sonic energy, and that within the range of variables investigated, the amount of enhancement was dependent more on natural convection and standing wave patterns than particle size and energy input per unit mass.
A Novel Approach For The Convergence Analysis Of The Least-Mean Fourth Algorithm (2004)

Publication in the conference proceedings of EUSIPCO, Viena, Austria, 2004
High Strength Polyolefin Block Copolymers (2004)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTHigh Strength Polyolefin Block CopolymersLisa S. Lim, Tamotsu Harada, Marc A. Hillmyer, and Frank S. BatesView Author Information Department of Chemical Engineering and Materials Science and Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455 Cite this: Macromolecules 2004, 37, 16, 5847–5850Publication Date (Web):July 16, 2004Publication History Received3 June 2004Revised24 June 2004Published online16 July 2004Published inissue 1 August 2004https://doi.org/10.1021/ma048898qCopyright © 2004 American Chemical SocietyRequest reuse permissionsArticle Views568Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (184 KB) Get e-AlertscloseSUBJECTS:Copolymers,Crystallinity,Polymers,Tensile strength,X-ray scattering Get e-Alerts
Dynamic modeling of constant curvature continuum robots using the Euler-Lagrange formalism (2014)

Dynamic models of continuum manipulators tend to become very complex, especially for spatial manipulators with multiple sections. Therefore a practicable model is needed that can be used for simulations and model-based control design. Neglecting rotational energies and assuming a continuum manipulator that consists of a single concentrated mass per section, dynamic equations for each actuator state are derived using the Euler-Lagrange formalism. Forces, positions and velocities are transformed to a global reference system using the homogeneous transformation based on constant curvature robot kinematics and its derivatives. Measurements of an example manipulator verify the resulting dynamic model that can be used to both simulate the dynamics and calculate the inverted robot dynamics needed for model-based controller design.
Physically reconfigurable antennas: Concepts and automation (2017)

This paper discusses concepts of three physically reconfigurable antennas that are software controlled and fully automated. Each of the three antennas reconfigures its operating frequency or radiation pattern based on a physical movement of some of its radiating parts. The antennas discussed vary from a frequency reconfigurable quadrifilar helix to a frequency reconfigurable sector monopole as well as a radiation pattern reconfigurable patch. The antennas discussed are fabricated and measured where a good analogy is found with the predicted data.
ChemInform Abstract: Enantioselective Synthesis of (R)‐(‐)‐Baclofen Using Fischer‐Type Carbene Anions. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Conventional transmission electron microscopy (2014)

Researchers have used transmission electron microscopy (TEM) to make contributions to cell biology for well over 50 years, and TEM continues to be an important technology in our field. We briefly present for the neophyte the components of a TEM-based study, beginning with sample preparation through imaging of the samples. We point out the limitations of TEM and issues to be considered during experimental design. Advanced electron microscopy techniques are listed as well. Finally, we point potential new users of TEM to resources to help launch their project.
Quantified lysis of cell-like lipid membranes due to nanoparticle-facilitated cavitation (2011)

Certain nanoparticles act as nucleation sites for acoustic cavitation. Their surface roughness and hydrophobic regions can decrease the pressure required to induce the cavitation event. This concept has been examined for potential to provide a sensitizer for high-intensity focused ultrasound (HIFU), where cavitation can be beneficial. While passive cavitation detection can accurately determine the pressure threshold, variations in acoustic impedance/backscatter from different nanoparticles can make it difficult to normalize the amount of cavitation and determine the precise magnitude of the physical consequences. Here we demonstrate a method to determine the extent of lysis of lipid membranes using liposomes loaded with a self-quenching fluorophore. Lysed liposomes released the fluorophore, causing an increase in the fluorescence signal. Liposomes were mixed with the nanoparticles and insonated with a HIFU transducer at physiological temperature. The pressure threshold for dye release was measured for a panel of nanoparticles. Nearly complete release of the dye was achievable in all cases, but it required higher pressures in the absence of nanoparticles. In addition, we measured the effect of a viscous medium, which is more representative of certain physiological states. Furthermore, the encapsulation of the nanoparticle within a liposome can create a platform delivery vehicle for anti-cancer therapeutics.
Supplementary Figure Legends from Upregulation of IGF1R by Mutant <i>RAS</i> in Leukemia and Potentiation of <i>RAS</i> Signaling Inhibitors by Small-Molecule Inhibition of IGF1R (2023)

&lt;p&gt;Figure Legends for data shown in supplementary data section&lt;/p&gt;
O-glycans on human high endothelial CD34 putatively participating in L-selectin recognition (2002)

Leukocyte traffic into lymph nodes and sites of inflammation is guided by L-selectin. Experiments performed in vitro and with gene-deleted mice suggest that CD34 recognizes L-selectin if decorated by 6-sulfo sialyl Lewis x (sLex) saccharides and the MECA-79 epitope. However, very little is known about glycosylation of human L-selectin ligands. We report here on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) profiles of N- and O-linked oligosaccharide fractions from human tonsillar endothelial CD34. All detected O-glycans were sialylated; some were also monosulfated or monosulfated and monofucosylated. If a given CD34-glycan may carry all requirements for L-selectin recognition, that is, both 6-sulfo-sLex and MECA-79 epitopes, only one O-glycan fraction, O-9, SA(2)Hex(3)HexNAc(3)- Fuc(1)(SO(3))(1), meets the criteria. A candidate structure is SAalpha2-3Galbeta1-4(Fucalpha1-3)(6-sulfo)GlcNAcbeta1-3Galbeta1-3(SAalpha2-3Galbeta1-4GlcNAcbeta1-6)GalNAc. However, if sulfo sLex glycans are supplemented with separate sulfated, nonfucosylated O-glycans, saccharides in O-6, O-8, or O-9, putatively carrying MECA-79 epitopes, could form multiglycan binding epitopes for L-selectin.
Optimal planning of distribution grids considering active power curtailment and reactive power control (2016)

In this paper, a new planning methodology is proposed for existing distribution grids, considering both passive and active network measures. The method is designed to be tractable for large grids of any type, e.g., meshed or radial. It can be used as a decision-making tool by distribution system operators which need to decide whether to invest in new hardware, such as new lines and transformers, or to initiate control measures influencing the operational costs. In this paper, active power curtailment and reactive power control are taken into account as measures to prevent unacceptable voltage rises as well as element overloads, as these allow postponing network investments. A low-voltage, meshed grid with 27 nodes is used to demonstrate the proposed scheme. In this particular case, the results show that by using control measures, an active distribution system operator can defer investments and operate the existing infrastructure more efficiently. The methodology is able to account for variations in operational and investment costs coming from regulatory influences to provide an insight to the most cost-efficient decision.
Nonlinear optical characterization of CdTe as applied lo limiting at 1.06 μm (1989)

Passive optical limiting based on two-photon absorption (2PA) and nonlinear refraction in semiconductors has been shown to be very effective in terms of high dynamic range and low limiting energy at visible wavelengths.1 Devices based on these nonlinearities have linear transmission for low inputs and a nearly constant output above a limiting threshold input. We have now extended this work to other semiconductors with suitable bandgaps for longer wavelengths.
Results of the North American Complex Abdominal Aortic Debranching (NACAAD) Registry (2022)

Mortality after hybrid repair and visceral debranching is highly variable by center, but strongly affected by preoperative comorbidities and the centers' experience with the technique. With excellent graft patency at 5 years, the outcomes of hybrid repair done at centers of excellence and in carefully selected patients may be comparable (or better) than traditional open or even totally endovascular approaches. However, in patients already considered as high-risk for surgery, it may not offer better outcomes.
Abstract 13808: Role of Cardiac Specific Follistatin-Like 1 in Heart Failure with Preserved Ejection Fraction (2011)

Solid-state methods for cooling and heating promise a sustainable alternative to current compression cycles of greenhouse gases and inefficient fuel-burning heaters. Barocaloric effects (BCE) driven by hydrostatic pressure (p) are especially encouraging in terms of large adiabatic temperature changes (|ΔT| ≈ 10 K) and isothermal entropy changes (|ΔS| ≈ 100 J K<sup>-1</sup> kg<sup>-1</sup>). However, BCE typically require large pressure shifts due to irreversibility issues, and sizeable |ΔT| and |ΔS| seldom are realized in a same material. Here, the existence of colossal and reversible BCE in LiCB<sub>11</sub>H<sub>12</sub> is demonstrated near its order-disorder phase transition at ≈380 K. Specifically, for Δp ≈ 0.23 (0.10) GPa, |ΔS<sub>rev</sub>| = 280 (200) J K<sup>-1</sup> kg<sup>-1</sup> and |ΔT<sub>rev</sub>| = 32 (10) K are measured, which individually rival with state-of-the-art BCE figures. Furthermore, pressure shifts of the order of 0.1 GPa yield huge reversible barocaloric strengths of ≈2 J K<sup>-1</sup> kg<sup>-1</sup> MPa<sup>-1</sup>. Molecular dynamics simulations are performed to quantify the role of lattice vibrations, molecular reorientations, and ion diffusion on the disclosed BCE. Interestingly, lattice vibrations are found to contribute the most to |ΔS| while the diffusion of lithium ions, despite adding up only slightly to the entropy change, is crucial in enabling the molecular order-disorder phase transition.
Transcription of the multidrug resistance gene MDR1: a therapeutic target. (2001)

Two decades ago, the overexpression of P-glycoprotein (Pgp) was first demonstrated to mediate the energy-dependent efflux of a variety of chemotherapeutic agents from tumor cells, resulting in the development of multidrug resistance (MDR). Not surprisingly, this discovery triggered an ongoing search for agents that would inhibit Pgp function, with the hope that by doing so the MDR phenotype could be reversed. As our understanding of Pgp function and pharmacokinetics has increased, this quest has become more urgent, as well as more complex.
Cross-Linkable Fullerene Derivatives for Solution-Processed n–i–p Perovskite Solar Cells (2016)

Hybrid perovskites form an extremely attractive class of materials for large scale, low-cost photovoltaic applications. Fullerene-based charge extraction layers have emerged as a viable n-type charge collection layer, and in “inverted” p–i–n device architectures the solar cells are approaching efficiencies of 20%. However, the regular n–i–p devices employing fullerenes still lag behind in performance. Here, we show that partial solubility of fullerene derivatives in the aprotic solvents used for the perovskites makes it challenging to retain integral films in multilayer solution processing. To overcome this issue we introduce cross-linkable fullerene derivatives as charge collection layers in n–i–p planar junction perovskite solar cells. The cross-linked fullerene layers are insolubilized and deliver improved performance in solar cells enabled by a controllable film thickness.