gebhart/patrepeval huggingface dataset:
Autosomal dominant amyotrophic lateral sclerosis: a novel mutation in the Cu/Zn superoxide dismutase-1 gene (1994)

Journal Article Autosomal dominant amyotrophic lateral sclerosis: a novel mutation in the Cu/Zn superoxide dismutase-1 gene Get access Markus Kostrzewa, Markus Kostrzewa Search for other works by this author on: Oxford Academic PubMed Google Scholar Uta Burck-Lehmann, Uta Burck-Lehmann 1Getreideweg 20, D-50933 K Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Ulrich Müller Ulrich Müller * *To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Molecular Genetics, Volume 3, Issue 12, December 1994, Pages 2261–2262, https://doi.org/10.1093/hmg/3.12.2261 Published: 01 December 1994 Article history Received: 30 September 1994 Accepted: 04 October 1994 Published: 01 December 1994
Supplemental Figure 2 from Diagnostic Distinction of Malignant Melanoma and Benign Nevi by a Gene Expression Signature and Correlation to Clinical Outcomes (2023)

&lt;p&gt;Supplemental Figure 2 shows a lesion from the right upper back of a 71 year old male that was classified as a superficial spreading melanoma ex nevus (Breslow thickness 0.69 mm, mitotic index 1/mm&lt;sup&gt;2&lt;/sup&gt;,ulceration absent). The score was +4.1 Metastases to the soft tissue of the right neck developed 16 months after initial diagnosis.&lt;/p&gt;
Analysis of Epitope-Specific Immune Responses Induced by Vaccination with Structurally Folded and Unfolded Recombinant Bet v 1 Allergen Derivatives in Man (2007)

Previously, we have constructed recombinant derivatives of the major birch pollen allergen, Bet v 1, with a more than 100-fold reduced ability to induce IgE-mediated allergic reactions. These derivatives differed from each other because the two recombinant Bet v 1 fragments represented unfolded molecules whereas the recombinant trimer resembled most of the structural fold of the Bet v 1 allergen. In this study, we analyzed the Ab (IgE, IgG subclass, IgA, IgM) response to Bet v 1, recombinant and synthetic Bet v 1-derived peptides in birch pollen allergic patients who had been vaccinated with the derivatives or adjuvant alone. Furthermore, we studied the induction of IgE-mediated skin responses in these patients using Bet v 1 and Bet v 1 fragments. Both types of vaccines induced a comparable IgG1 and IgG4 response against new sequential epitopes which overlap with the conformational IgE epitopes of Bet v 1. This response was 4- to 5-fold higher than that induced by immunotherapy with birch pollen extract. Trimer more than fragments induced also IgE responses against new epitopes and a transient increase in skin sensitivity to the fragments at the beginning of therapy. However, skin reactions to Bet v 1 tended to decrease one year after treatment in both actively treated groups. We demonstrate that vaccination with folded and unfolded recombinant allergen derivatives induces IgG Abs against new epitopes. These data may be important for the development of therapeutic as well as prophylactic vaccines based on recombinant allergens.
Scintillation and dosimeter properties of Ce-doped Li<sub>3</sub>PO<sub>4</sub>&ndash;Al(PO<sub>3</sub>)<sub>3</sub> glasses (2016)

In this study, we developed Li3PO4–Al(PO3)3 glasses doped with different concentrations (0, 0.1, 0.2, 0.5 and 1.0%) of Ce and studied the optical, scintillation and dosimeter properties. The scintillation and photoluminescence (PL) emissions showed an intense emission due to the 5d–4f transitions of Ce3+. In addition, the scintillation and PL decay times of Ce3+ were obtained for 25–32 and 26–29 ns, respectively. These results were typical for Ce-doped scintillator. Moreover, as a dosimeter property, 0, 0.1, 0.5 and 1.0% Ce-doped glass samples showed thermally stimulated luminescence (TSL) around 150–200 and 350–400°C with a good liner response over 0.5–10 Gy.
Quality of data driven simulation workflows (2012)

Simulations are characterized by long running calculations and complex data handling tasks accompanied by non-trivial data dependencies. The workflow technology helps to automate and steer such simulations. Quality of Data frameworks are used to determine the goodness of simulation data, e.g., they analyze the accuracy of input data with regards to the usability within numerical solvers. In this paper, we present generic approaches using evaluated Quality of Data to steer simulation workflows. This allows for ensuring that the predefined requirements such as a precise final result or a short execution time will be met even after the execution of simulation workflow has been started. We discuss mechanisms for steering a simulation on all relevant levels - workflow, service, algorithms, and define a unifying approach to control such workflows. To realize Quality of Data-driven workflows, we present an architecture realizing the presented approach and a WS-Policy-based language to describe Quality of Data requirements and capabilities.
Lack of evidence of phenotypic complementation of E1A/E1B-deleted adenovirus type 5 upon superinfection by wild-type virus in the cotton rat (1995)

The safety of replication-defective viruses used as vectors is based on the deletion of essential gene(s). Adenovirus vector safety relies on the deletion of the E1A/E1B region. This region encodes the immediate-early proteins that trans activate all other early regions, so DNA replication in these deletion mutants is dramatically reduced. We have previously shown that E1A deletion is efficient in vivo and significantly reduces the dissemination of adenovirus in mice and cotton rats. However, the pattern of dissemination of E1A-deleted and wild-type viruses showed that both could be localized in the same tissues, thus involving a theoretical risk of phenotypic complementation if a recipient of E1A-deleted adenovirus is infected after adenovirus-mediated gene therapy by a wild-type adenovirus. In this report, we show that complementation can be evidenced in vitro in Vero cells infected with E1A/E1B-defective adenovirus vectors expressing reporter genes (either beta-galactosidase or luciferase), passaged three times until no infectious virus can be recovered by plating on 293 cells, and then infected with wild-type adenovirus 5. A mixed virus population was maintained at a stable state for at least 10 passages. In contrast, no evidence of complementation was found in cotton rats inoculated intravenously or intramuscularly with Ad-beta-gal-nls and Ad-luc and infected 24 h later intranasally with wild-type adenovirus 5. No increase in the level of luciferase expression was found in these animals, compared with that in controls, nor was any viral population expressing beta-galactosidase or luciferase isolated from various organs or any animal excretion or secretion.
Deep Learning-Based Optimal RIS Interaction Exploiting Previously\n Sampled Channel Correlations (2020)

The reconfigurable intelligent surface (RIS) technology has attracted\ninterest due to its promising coverage and spectral efficiency features.\nHowever, some challenges need to be addressed to realize this technology in\npractice. One of the main challenges is the configuration of reflecting\ncoefficients without the need for beam training overhead or massive channel\nestimation. Earlier works used estimated channel information with deep learning\nalgorithms to design RIS reflection matrices. Although these works can reduce\nthe beam training overhead, still they overlook existing correlations in the\npreviously sampled channels. In this paper, different from existing works, we\npropose to exploit the correlation in the previously sampled channels to\nestimate RIS interaction more reliably. We use a deep multi-layer perceptron\nfor this purpose. Simulation results reveal performance improvements achieved\nby the proposed algorithm.\n
Pneumatic Testing of Piping Assemblies: Criteria for Stored Energy and Pinhole Leak Detectability (2021)

Abstract Pneumatic testing is beneficial as an alternative to hydrotesting particularly in remote areas where access to hydrotest fluids becomes logistically difficult or impossible. In some cases, above-ground pipe supports cannot hold the water weight, or that the pipe is coated/lined with materials that would degrade with water/methanol/glycol mixtures, or the system cannot be fully dried and the remaining hydrotest fluids are detrimental to the service application once the system is commissioned. Additionally, the elevation profile of the piping is such that an excessive number of test sections would be required for hydrotesting according to most codes. The present work is aimed at addressing two salient questions often faced with pneumatic testing. The first is related to the appropriate piping volume to consider for calculating the stored energy in use with ASME Post Construction Committee (PCC)-2 calculation for determining the safe exclusion distance for a given piping geometry and test conditions. It was found that the 8D criteria specified in ASME PCC-2 cannot be generalized for all pipe sizes, different material toughness, grades, wall thicknesses, and test conditions. A criterion is developed based on the ductile fracture arrest length that considers all these factors combined. The second criterion is related to the ability to detect a pinhole leak from the pneumatic test data, again for a given geometry and test conditions, and what constitutes the minimum pinhole effective area in relation to the system total volume, measured uncertainties in the test pressure and temperature over the duration of the test. A seminormalized physics-based parameter is suggested that can be applied to determine the effective pinhole leak size. The methodology is applied to a pneumatic field test on DN200, 12.2 km pipeline lateral.
Supplementary material from "Improving axial resolution in SIM using deep learning" (2021)

Structured Illumination Microscopy (SIM) is a widespread methodology to image live and fixed biological structures smaller than the diffraction limits of conventional optical microscopy. Using recent advances in image up-scaling through deep learning models, we demonstrate a method to reconstruct 3D-SIM image stacks with twice the axial resolution attainable through conventional SIM reconstructions. We further demonstrate our method is robust to noise and evaluate it against two point cases and axial gratings. Finally, we discuss potential adaptions of the method to further improve resolution.‘This article is part of the theme issue ‘SIMposium (part 1)’.’
Sveriges utrikeshandel med NIE-länderna (2003)

Validerat; 20101217 (root)
An Affine Projection Sign Algorithm Robust Against Impulsive Interferences (2010)

A new affine projection sign algorithm (APSA) is proposed, which is robust against non-Gaussian impulsive interferences and has fast convergence. The conventional affine projection algorithm (APA) converges fast at a high cost in terms of computational complexity and it also suffers performance degradation in the presence of impulsive interferences. The family of sign algorithms (SAs) stands out due to its low complexity and robustness against impulsive noise. The proposed APSA combines the benefits of the APA and SA by updating its weight vector according to the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">L</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> -norm optimization criterion while using multiple projections. The features of the APA and the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">L</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> -norm minimization guarantee the APSA an excellent candidate for combatting impulsive interference and speeding up the convergence rate for colored inputs at a low computational complexity. Simulations in a system identification context show that the proposed APSA outperforms the normalized least-mean-square (NLMS) algorithm, APA, and normalized sign algorithm (NSA) in terms of convergence rate and steady-state error. The robustness of the APSA against impulsive interference is also demonstrated.
Analysis Of DNA-Polyamine Interactions Using SERS-Coated Microplates In A Dedicated Raman Plate Reader (2010)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Igor Zlatkin, David Drapcho, Stuart Farquharson; Analysis Of DNA‐Polyamine Interactions Using SERS‐Coated Microplates In A Dedicated Raman Plate Reader. AIP Conference Proceedings 6 August 2010; 1267 (1): 1093–1094. https://doi.org/10.1063/1.3482314 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
A comparative study of data from different DAS interrogators (2021)

Distributed acoustic sensing is a technology with a high potential for seismic monitoring. Apart from the optical fibre, that is the sensing element that replaces the traditional geophone, the other part of this system is the interrogator that transforms the back-scattered light from the fibre into a digital seismic signal. The fibre is usually installed permanently but the interrogator is interchangeable, not only by newer and more sophisticated models, but by different vendors’ models. We compare distributed acoustic sensing data obtained at the same locations, with the same sources and optical fibre, and almost at the same frame time, but generated by interrogators from three different vendors, at the Containment and Monitoring Institute Field Research Station in Alberta, Canada. We compare these datasets with one other, and also against vertically oriented geophone data. We found that after some data conditioning, all vendors agree in wave character at the early times, however, at later times there are delays in the events arrivals that depend on the trace depth.
Reconstruction of Hyaline Cartilage Deep Layer Properties in 3-Dimensional Cultures of Human Articular Chondrocytes (2014)

The HC tissue obtained by the method described can be used to develop an implantable product for the replacement of damaged or malformed AC, especially in younger patients where the lesions are caused by trauma or mechanical stress.
Adaptive and Real-Time Optimal Control of Stick–Slip and Bit Wear in Autonomous Rotary Steerable Drilling (2017)

Deviated, horizontal, and multilateral wells are drilled to increase the contact area between the well path and the reservoir and as a result, the well productivity will be increased. Directional steering systems (DSS) are used to control the direction in nonvertical wells. Rotary steerable system (RSS) is the current state of the art of DSS. In this research, the problem of real-time control of autonomous RSS with unknown formation rock strength was presented. The aim of this study is to develop a real-time control scheme for real-time optimization of drilling parameters to (1) maximize the rate of penetration (ROP), (2) minimize the deviation from the planned well bore trajectory, (3) reduce the stick–slip oscillations, and (4) assess the degree of bit wear. Nonlinear model for the drilling operation was developed using energy balance equation, where rock specific energy (RSE) is used to calculate the minimum power required for a given ROP. A proposed mass spring system was used to represent the phenomena of stick–slip oscillation. The model parameters have been adaptively estimated at each control iteration to tackle any disturbances or variations in the formation properties. The bit wear is mathematically represented using Bourgoyne model. Detailed mathematical formulation and computer simulation were used for evaluation of the performance of the proposed technique based on real well field data. The obtained results showed excellent ability to accommodate the changes in the formation properties. In addition, the rates of bit wear and stick–slip oscillations have been optimized.
Immunotoxin SS1P is rapidly removed by proximal tubule cells of kidney, whose damage contributes to albumin loss in urine (2020)

Recombinant immunotoxins (RITs) are chimeric proteins composed of an Fv and a protein toxin being developed for cancer treatment. The Fv brings the toxin to the cancer cell, but most of the RITs do not reach the tumor and are removed by other organs. To identify cells responsible for RIT removal, and the pathway by which RITs reach these cells, we studied SS1P, a 63-kDa RIT that targets mesothelin-expressing tumors and has a short serum half-life. The major organs that remove RIT were identified by live mouse imaging of RIT labeled with FNIR-Z-759. Cells responsible for SS1P removal were identified by immunohistochemistry and intravital two-photon microscopy of kidneys of rats. The primary organ of SS1P removal is kidney followed by liver. In the kidney, SS1P passes through the glomerulus, is taken up by proximal tubular cells, and transferred to lysosomes. In the liver, macrophages are involved in removal. The short half-life of SS1P is due to its very rapid filtration by the kidney followed by degradation in proximal tubular cells of the kidney. In mice treated with SS1P, proximal tubular cells are damaged and albumin in the urine is increased. SS1P uptake by kidney is reduced by coadministration of l-lysine. Our data suggests that l-lysine administration to humans might prevent SS1P-mediated kidney damage, reduce albumin loss in urine, and alleviate capillary leak syndrome.
Positronium emission from GaN(0001) and AlN(0001) surfaces (2021)

Abstract Positronium emission from wurtzite GaN(0001) and AlN(0001) surfaces was observed by positronium time-of-flight spectroscopy. The positronium energy spectra contained two positronium components distinguished by their energies. Through detailed analyses based on Monte Carlo simulations, these two components were attributed to positronium formed from valence and conduction electrons. The obtained results augment the previous arguments regarding the contribution of conduction electrons to positronium emission from 4H SiC(0001) and Si(111) surfaces.
ChemInform Abstract: Fused Pyrrolo(2,3‐c)carbazol‐6‐ones: Novel Immunostimulants That Enhance Human Interferon‐γ Activity. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ALGORITHM FOR IN VIVO CW FLUORESCENCE DIFFUSE OPTICAL TOMOGRAPHY TAKING INTO ACCOUNT OPTICAL HETEROGENEITIES OF BIOLOGICAL TISSUES AND THE SHAPE OF THE ANIMAL (2007)

A fluorescence enhanced diffuse optical tomography algorithm taking into account the optical heterogeneities is presented. It is suitable for continuous wave acquisitions and naturally handles complex shaped object. Therefore, it allows in vivo studies of small animals injected with target-specific fluorescent probes without immersion fluid. A comparison with previous methods conducted on simulations is presented. A validation experiment performed on the same mouse at different stage of lung tumors growth shows the ability of the system to be used for biological studies
The Anaplastic Lymphoma Kinase Controls Cell Shape and Growth of Anaplastic Large Cell Lymphoma through Cdc42 Activation (2008)

Anaplastic large cell lymphoma (ALCL) is a non-Hodgkin's lymphoma that originates from T cells and frequently expresses oncogenic fusion proteins derived from chromosomal translocations or inversions of the anaplastic lymphoma kinase (ALK) gene. The proliferation and survival of ALCL cells are determined by the ALK activity. Here we show that the kinase activity of the nucleophosmin (NPM)-ALK fusion regulated the shape of ALCL cells and F-actin filament assembly in a pattern similar to T-cell receptor-stimulated cells. NPM-ALK formed a complex with the guanine exchange factor VAV1, enhancing its activation through phosphorylation. VAV1 increased Cdc42 activity, and in turn, Cdc42 regulated the shape and migration of ALCL cells. In vitro knockdown of VAV1 or Cdc42 by short hairpin RNA, as well as pharmacologic inhibition of Cdc42 activity by secramine, resulted in a cell cycle arrest and apoptosis of ALCL cells. Importantly, the concomitant inhibition of Cdc42 and NPM-ALK kinase acted synergistically to induce apoptosis of ALCL cells. Finally, Cdc42 was necessary for the growth as well as for the maintenance of already established lymphomas in vivo. Thus, our data open perspectives for new therapeutic strategies by revealing a mechanism of regulation of ALCL cell growth through Cdc42.
Design, Synthesis and Anticancer Profile of New 4-(1H-benzo[d]imidazol-1-yl)pyrimidin-2-amine-Linked Sulfonamide Derivatives with V600EBRAF Inhibitory Effect (2021)

A new series of 4-(1<i>H</i>-benzo[<i>d</i>]imidazol-1-yl)pyrimidin-2-amine linked sulfonamide derivatives <b>12a-n</b> was designed and synthesized according to the structure of well-established V600EBRAF inhibitors. The terminal sulfonamide moiety was linked to the pyrimidine ring via either ethylamine or propylamine bridge. The designed series was tested at fixed concentration (1 µM) against V600EBRAF, finding that <b>12e</b>, <b>12i</b> and <b>12l</b> exhibited the strongest inhibitory activity among all target compounds and <b>12l</b> had the lowest IC<sub>50</sub> of 0.49 µM. They were further screened on NCI 60 cancer cell lines to reveal that <b>12e</b> showed the most significant growth inhibition against multiple cancer cell lines. Therefore, cell cycle analysis of <b>12e</b> was conducted to investigate the effect on cell cycle progression. Finally, virtual docking studies was performed to gain insights for the plausible binding modes of vemurafenib, <b>12i</b>, <b>12e</b> and <b>12l</b>.
Supplementary Figure S3 from CD47 Enhances <i>In Vivo</i> Functionality of Artificial Antigen-Presenting Cells (2023)

&lt;p&gt;Supplementary Figure S3. Schematics of the in vivo experiments performed and in vitro aAPC/aAPCCD47+ proliferation assay.&lt;/p&gt;
Outcomes Associated with In-Center Nocturnal Hemodialysis from a Large Multicenter Program (2009)

Patients who were on INHD exhibited excellent quality indicators, with better survival and lower hospitalization rates. The relative contributions of patient selection versus effect of therapy on outcomes remain to be elucidated in prospective clinical trials.
Unified analysis of four-photon mixing, modulational instability, and stimulated Raman scattering under various polarization conditions in fibers (1994)

We present the analysis of parametric and Raman effects in the framework of a single approach. We discuss the transformation of gain spectra for Stokes and anti-Stokes waves under pump wavelength tuning from the region of positive group-velocity dispersion to the region of negative group-velocity dispersion for different types of phase-matching mechanism in a birefringent fiber.