gebhart/patrepeval huggingface dataset:
Effect of allylic substituents on the face selectivity of Diels-Alder reactions of semicyclic dienes (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of allylic substituents on the face selectivity of Diels-Alder reactions of semicyclic dienesS. C. Datta, R. W. Franck, R. Tripathy, G. J. Quigley, L. Huang, S. Chen, and A. SihaedCite this: J. Am. Chem. Soc. 1990, 112, 23, 8472–8478Publication Date (Print):November 1, 1990Publication History Published online1 May 2002Published inissue 1 November 1990https://pubs.acs.org/doi/10.1021/ja00179a036https://doi.org/10.1021/ja00179a036research-articleACS PublicationsRequest reuse permissionsArticle Views363Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Predicting the dynamic behavior of axial-field actuators (1996)

A method is presented for predicting the dynamic behavior of axial-field actuators. This method entails the numerical solution of a system of nonlinear differential equations that govern the dynamics. The theory is applied to a specific actuator geometry, and the predicted results are compared with empirical data.
<title>Photovoltaic response in poly(3-octylthiophene)-based metal-semiconductor-metal diodes</title> (2001)

We report here on properties of Metal-Semiconductor-Metal cells based on poly(3-octylthiophene), P3OT. The diodes were fabricated by spin-coating of poly (3-octylthiophene) on an indium-tin oxide coated glass substrate and an aluminum top contact was evaporated onto the film. The optical and electrical characteristics of the diodes were studied. A power efficiency of 10<SUP>-4</SUP> was obtained at AM 1.5 conditions, while the power efficiency reached its maximum of 6% under illumination at 256 nm at an intensity of 2 (mu) W/cm<SUP>2</SUP>.
Proinflammatory cytokines regulate antigen‐independent T‐cell Activation by two separate calcium‐signaling pathways in multiple sclerosis patients (1998)

Central nervous system (CNS) lesions typical of multiple sclerosis (MS) are characterized by demyelinating inflammatory infiltrates that contain few CNS antigen-specific autoreactive T cells and a multitude of pathogenic non-antigen-specific mononuclear cells. Here, we report that in patients with MS the combined action of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNFalpha), interleukin (IL)-2, and IL-6 leads to the activation of most peripheral T cells (mainly CD4 memory) by promoting a persistent intracellular calcium increase via two independent signaling pathways. The activation of these pathways, one activated by IFNgamma and the other by the combination TNFalpha/IL-2/IL-6, is independent from myelin antigens and precedes by 2 weeks phases of disease activity (eg, clinical relapses and/or appearance of gadolinium-enhancing lesions on brain magnetic resonance imaging scans during 1 year of follow-up). Our results indicate that an appropriate combination of the four cytokines, three with a proinflammatory profile and one necessary for T-cell growth and differentiation, can activate in an antigen-independent fashion most peripheral T cells from MS patients. This mechanism is likely to contribute to the recruitment of nonspecific lymphocytes into the cellular activation processes leading to CNS demyelination and may represent a major target for immune intervention in MS.
Spinocerebellar ataxia type 1 and Machado-Joseph disease: incidence of CAG expansions among adult-onset ataxia patients from 311 families with dominant, recessive, or sporadic ataxia. (1995)

The ataxias are a complex group of diseases with both environmental and genetic causes. Among the autosomal dominant forms of ataxia the genes for two, spinocerebellar ataxia type 1 (SCA1) and Machado-Joseph disease (MJD), have been isolated. In both of these disorders the molecular basis of disease is the expansion of an unstable CAG trinucleotide repeat. To assess the frequency of the SCA1 and MJD trinucleotide repeat expansions among individuals diagnosed with ataxia we have collected DNA from individuals representing 311 families with adult-onset ataxia of unknown etiology and screened these samples for trinucleotide repeat expansions within the SCA1 and MJD genes. Within this group there are 149 families with dominantly inherited ataxia. Of these, 3% had SCA1 trinucleotide repeat expansions, whereas 21% were positive for the MJD trinucleotide expansion. Thus, together SCA1 and MJD represent 24% of the autosomal dominant ataxias in our group, and the frequency of MJD is substantially greater than that of SCA1. For the 57 patients with MJD trinucleotide repeat expansions, a strong inverse correlation between CAG repeat size and age at onset was observed (r = -.838). Among the MJD patients, the normal and affected ranges of CAG repeat size are 14-40 and 68-82 repeats, respectively. For SCA1 the normal and affected ranges are much closer, containing 19-38 and 40-81 CAG repeats, respectively.
Business-driven PCE for inter-carrier QoS connectivity services (2011)

New value added services such as gaming on demand, premium VoIP and videoconferencing and cloud computing services impose strong Quality of Service guarantee requirement. However, ensure such a Quality of Service through multiple carriers, remains a challenge for Network Service Providers, particularly, when confidentiality issues and business policies are involved. In this paper, we discuss a novel bottom-up approach which aims to accommodate business objectives and network resource usage in a business-driven PCE.
Characterization of O-Acetylation of N-Acetylglucosamine (2011)

Peptidoglycan (PG) N-acetyl muramic acid (MurNAc) O-acetylation is widely spread in gram-positive bacteria and is generally associated with resistance against lysozyme and endogenous autolysins. We report here the presence of O-acetylation on N-acetylglucosamine (GlcNAc) in Lactobacillus plantarum PG. This modification of glycan strands was never described in bacteria. Fine structural characterization of acetylated muropeptides released from L. plantarum PG demonstrated that both MurNAc and GlcNAc are O-acetylated in this species. These two PG post-modifications rely on two dedicated O-acetyltransferase encoding genes, named oatA and oatB, respectively. By analyzing the resistance to cell wall hydrolysis of mutant strains, we showed that GlcNAc O-acetylation inhibits N-acetylglucosaminidase Acm2, the major L. plantarum autolysin. In this bacterial species, inactivation of oatA, encoding MurNAc O-acetyltransferase, resulted in marked sensitivity to lysozyme. Moreover, MurNAc over-O-acetylation was shown to activate autolysis through the putative N-acetylmuramoyl-L-alanine amidase LytH enzyme. Our data indicate that in L. plantarum, two different O-acetyltransferases play original and antagonistic roles in the modulation of the activity of endogenous autolysins.
Chronic Hyperglycemia in Experimental Diabetes mellitus of Short Duration Does Not Contribute to Muscle Capillary Basement Membrane Thickening (1990)

The effect of chronic hyperglycemia on the relationship of nonenzymatic glycation and capillary basement membrane thickness in muscle was studied in streptozotocin-induced diabetic rats early in the course of diabetes mellitus. Diabetic animals were placed on either standard (24%) or restricted (8%) protein diet. The animals on 8% protein diet had elevated glycated hemoglobin levels (p less than 0.01) and increased levels of nonenzymatic glycation of basement membrane (p less than 0.01) as compared to insulin-treated diabetic (euglycemic), age-matched control, and streptozotocin-injected nondiabetic animals also on 8% protein diet. In contrast, diabetic animals on restricted (8%) protein diet and those on standard (24%) protein diet showed no statistical differences between them with regards to the above parameters. Moreover, there were no statistical differences among diabetic and control animals on either 8 or 24% protein diet with respect to muscle capillary membrane thickness. Even though the peripheral muscle biopsy study of capillary basement membrane is less invasive than kidney biopsy, the results of this study suggest that neither nonenzymatic glycation nor basement membrane thickness can be utilized as predictors of renal dysfunction during early onset of diabetes mellitus.
Consensus Recommendations for Management and Counseling of Adverse Events Associated With Lorlatinib: A Guide for Healthcare Practitioners (2020)

Resistance to first- and second-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) and development and progression of central nervous system metastases remain significant issues in the treatment of ALK-positive non-small-cell lung cancer. Lorlatinib is a novel third-generation ALK TKI that is able to penetrate the blood-brain barrier and has broad-spectrum potency against most known resistance mutations that can develop during treatment with crizotinib and second-generation ALK TKIs. The safety profile of lorlatinib is distinct from those of other ALK TKIs. Adverse events are typically mild to moderate in severity, seldom result in permanent discontinuations, and are generally manageable through lorlatinib dose modifications and/or standard medical therapy. This article provides guidance to advanced practice providers (e.g., nurses, nurse practitioners, physician assistants) and oncology pharmacists for the clinical management of key lorlatinib-emergent adverse reactions (i.e., hyperlipidemias, central nervous system effects, bodyweight increase, edema, and peripheral neuropathy). As lorlatinib is both a substrate and inducer of the CYP3A enzyme system and is contraindicated with strong CYP3A inducers, relevant drug-drug interactions are also highlighted.
Urolithiasis, Endourology and Laparoscopy (2006)

No AccessJournal of UrologyAdult urology1 Oct 2006Urolithiasis, Endourology and Laparoscopy Ralph ClaymanM.D. Ralph ClaymanRalph Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2006.06.109AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Urolithiasis, Endourology and Laparoscopy." The Journal of Urology, 176(4), pp. 1370–1371 References 1 : Imaging of adrenal incidentalomas: current status. AJR Am J Roentgenol2002; 179: 559. Google Scholar © 2006 by American Urological AssociationFiguresReferencesRelatedDetails Volume 176Issue 4October 2006Page: 1370-1371 Advertisement Copyright & Permissions© 2006 by American Urological AssociationMetricsAuthor Information Ralph Clayman More articles by this author Expand All Advertisement Loading ...
A semi-automatic method for resolving occlusion in augmented reality (2002)

Realistic merging of virtual and real objects requires that the augmented patterns be correctly occluded by foreground objects. In this paper we propose a semi-automatic method for resolving occlusion in augmented reality which makes use of key-views. Once the user has outlined the occluding objects in the key-views, our system detects automatically these occluding objects in the intermediate views. A region of interest that contains the occluding objects is first computed from the outlined silhouettes. One of the main contribution of this paper is that this region takes into account the uncertainty on the computed interframe motion. Then a deformable region-based approach is used to recover the actual occluding boundary within the region of interest from this prediction.
Oncogenic Kinase Bcr-Abl and Its Resistance to Pharmacological Inhibitors (2008)

The advances in understanding of neoplastic transformation considerably help the design of molecular-targeted therapies. Protein kinases are critical components of cellular signalling pathways and, due to their frequent deregulation in cancer cells, they have become one of the most important targets in drug development. The efficiency of imatinib in the treatment of chronic myeloid leukemia is a strong evidence that kinase inhibitors can be effective drugs, although some patients develop resistance to them. The structure-based design, however, allows synthesis of second-generation drugs, which are able to overcome this resistance. The review focuses on oncogenic Bcr-Abl as an example of a rational target for kinase inhibitors, their development and biochemical properties.
Anti-Inflammatory Drug Design Using a Molecular Hybridization Approach (2011)

The design of new drugs with better physiochemical properties, adequate absorption, distribution, metabolism, and excretion, effective pharmacologic potency and lacking toxicity remains is a challenge. Inflammation is the initial trigger of several different diseases, such as Alzheimer's disease, asthma, atherosclerosis, colitis, rheumatoid arthritis, depression, cancer; and disorders such as obesity and sexual dysfunction. Although inflammation is not the direct cause of these disorders, inflammatory processes often increase related pain and suffering. New anti-inflammatory drugs developed using molecular hybridization techniques to obtain multiple-ligand drugs can act at one or multiple targets, allowing for synergic action and minimizing toxicity. This work is a review of new anti-inflammatory drugs developed using the molecular modification approach.
Resolvin Infectious Inflammation by Targeting the Host Response (2015)

Newly discovered antiinflammatory molecules, dubbed resolvins, accelerate the resolution of inflammation in mice infected with E. coli and increase their survival.
Supplementary Figure S3 from Proteasome Inhibitors Trigger NOXA-Mediated Apoptosis in Melanoma and Myeloma Cells (2023)

Supplementary Figure S3 from Proteasome Inhibitors Trigger NOXA-Mediated Apoptosis in Melanoma and Myeloma Cells
Ripple analysis: Identify and quantify reflective interference through ISI decomposition (2016)

Modern chip to chip communication systems are often limited by reflective interference created by impedance discontinuities in the interconnect. Common approaches to reducing the inter-symbol interference (ISI) in the passive interconnect are primitive, time consuming and prone to user bias. When the interconnect is viewed as a signal-flow graph, the channel response can be analytically expressed through Mason's rule. The expression is simplified to enable decomposing the ISI into resonant loop contributions created by impedance discontinuity pairs. This data can be used to choose which discontinuities to redesign, and to bound the expected benefit.
P2A-5 Guided Automatic Segmentation of the Murine Left Ventricle Using Conservation of Myocardial Volume (2007)

Computation of important metrics of cardiac function - specifically left ventricular end systolic and end diastolic volume - necessitate accurate segmentation of myocardial boundaries in 3D image data sets. Automatic segmentation is highly dependent on appropriate selection of segmentation algorithm parameters. We propose the use of conservation of myocardial volume - that is, the difference in volumes between the epicardial and endocardial surface segmentations - as a metric of efficacy of a particular set of model parameters for the gradient vector flow field algorithm. The metric was found to be an effective predictor for the efficacy of the gradient vector field parameter - models generated from parameter values which exhibited strong conservation of volume yielded more accurate segmentations of both synthetic and in vivo data.
Detection and recognition of end-of-speed-limit and supplementary signs for improved european speed limit support (2008)

Abstract. We present two new features for our prototype of European Speed Limit Support system: detection and recognition of end-of-speed-limit signs, as well as a framework for detection and recognition of supplementary signs located below main signs and modifying their scope (particular lane, class of vehicle, etc…). The end-of-speed-limit signs are globally-recognized by a Multi-Layer Perceptron (MLP) neural network. The supplementary signs are detected by applying a rectangle-detection in a region below recognized speed-limit signs, followed by a MLP neural network recognition. A common French+German end-of-speed-limit signs recognition has been designed and successfully tested, yielding 82 % detection+recognition. Results for detection and recognition of a first kind of supplementary sign (French exit-lane) are already satisfactory (78 % correct detection rate), and our framework can easily be extended to handle other types of supplementary signs. To our knowledge, we are the first team presenting results on detection and recognition of supplementary signs below speed signs, which is a crucial feature for a reliable Speed Limit Support.
Development of low CHE, negative-tone, photo-definable polyimide for HDD suspension (2012)

A negative-tone photo-definable polyimide with a low CHE has been developed for coating suspension heads in HDD applications. In order to select the low CHE polyimide, the stabilization energy of hydration calculated from the polyimide and water by Gaussian 03 was used as an indicator. A good correlation between the stabilization energy and CHE value of the polyimide was obtained and which resulted in the development of a low CHE, negative-tone, photo-definable polyimide. The developed material has a low CHE of 9 ppm/%RH, a CTE of 17 ppm/°C (matching that of stainless steel) and good lithographic properties.
Magnetic Nanocomposites and Their Incorporation into Higher Order Biosynthetic Functional Architectures (2018)

A magnetically active Fe<sub>3</sub>O<sub>4</sub>/poly(ethylene oxide)-<i>block</i>-poly(butadiene) (PEO-<i>b</i>-PBD) nanocomposite is formed by the encapsulation of magnetite nanoparticles with a short-chain amphiphilic block copolymer. This material is then incorporated into the self-assembly of higher order polymer architectures, along with an organic pigment, to yield biosynthetic, bifunctional optical and magnetically active Fe<sub>3</sub>O<sub>4</sub>/bacteriochlorophyll <i>c</i>/PEO-<i>b</i>-PBD polymeric chlorosomes.
Growth and accumulation dynamics of poly(3‐hydroxyalkanoate) (PHA) in Pseudomonas putida GPo1 cultivated in continuous culture under transient feed conditions (2011)

It has been shown that Pseudomonas putida GPo1 is able to grow in continuous culture simultaneously limited by ammonium (N source) and octanoate (C source), and concomitantly accumulate poly([R]-3-hydroxyalkanoate) (PHA). Under such growth conditions the material properties of PHA can be fine-tuned if a second PHA precursor substrate is supplied. To determine the range of dual carbon and nitrogen (C, N)-limited growth conditions, tedious chemostat experiments need to be carried out for each carbon source separately. To determine the growth regime, the C/N ratio of the feed (f) to a chemostat was changed in a stepwise manner at a constant dilution rate of 0.3/h. Dual-(C, N)-limited growth was observed between C(f) /N(f) ≤ 6.4 g/g and C(f) /N(f) >9.5 g/g. In the following, we analyzed alternative approaches, using continuous medium gradients at the same dilution rate, that do not require time consuming establishments of steady states. Different dynamic approaches were selected in which the C(f) /N(f) ratio was changed continuously through a convex increase of C(f) , a convex increase of N(f) , or a linear decrease of C(f) (gradients 1, 2, and 3, respectively). In these experiments, the dual-(C, N)-limited growth regime was between 7.2 and 11.0 g/g for gradient 1, 4.3 and 6.9 g/g for gradient 2, and 5.1 and 8.9 g/g for gradient 3. A mathematical equation was developed that compensated a time delay of the gradient that was caused by the wash-in/wash-out effects of the medium feed.
Calculation of the Mean Pressure with Less Delay for Real-Time Clinical Monitoring (2006)

The mean of cardiovascular pressure signals is an important metric in patient monitoring applications for many types of diseases and injuries. It is typically calculated with a moving average of 3-8 s of the pulsatile signal. This method of calculating the mean introduces a delay of 1.5-4 s. We demonstrate that an FIR filter with coefficients calculated with a least squares error (LSE) estimator can reduce this delay without a clinically significant impact on the accuracy of the displayed signal. Preliminary results with intracranial pressure signals show that the delay can be completely eliminated with a maximum root-mean-square error of approximately 1 mmHg. Reduction or elimination of this delay could permit patient monitors to display the mean in real time and permit clinicians to respond to acute events more rapidly
Guest Editorial: Visual Analytics in Multimedia—Opportunities and Research Challenges (2016)

The ten papers in this special section are devoted to the topic of visual analytics, an emerging research direction that focuses on data exploration and analysis with a seamless integration of interaction, visualization, and analysis.
Natural medicinal resources and their therapeutic applications (2019)

Natural medicinal resources are a country’s natural wealth. Natural medicinal waters, medicinal gases, and peloids have many properties that enable their use in the treatment of gastrointestinal, circulatory, respiratory, bone and joint, and skin and soft tissue disorders. Balneotherapy can be also applicable in prevention of many diseases and rehabilitation. At present, because there are several chemicals of synthetic origin, there is a need to search for nonpharmacological approaches and explore natural healing sources, which better fit the human body. Compared to synthetic drugs, these resources rarely show side effects, which increases the comfort of therapy. The use of natural medicinal resources in the form of treatments in health resort medicine centers under the supervision of balneologists, combined with the healing properties of the climate, contributes not only to the reduction of treatment time for many diseases but also to improvement of therapy’s results. The article discusses natural medicinal resources and some of their therapeutic applications.
Rate-distortion optimized frame level rate control for H.264/AVC (2008)

In this paper, a rate-distortion optimized frame level rate con-trol algorithm is presented for H.264/AVC. To improve the performance in both distortion and rate, two techniques are developed. First, an adaptive frame layer rate-distortion op-timization technique is included into the rate control mod-ule so that the average distortion is decreased. Second, the mapping from the bit budget to the quantization step is well considered at frame level by an accurate rate model. Con-sequently, a more precise control over the rate is achieved. Simulations show that the proposed rate control outperforms both the coding with fixed quantization step size (Fixed-QP) and the recommended rate control JVT-G012 in the H.264/AVC reference software. Compared with Fixed-QP, a gain up to 1.04 dB is observed and the maximal rate mis-match for seven sequences is only 0.61%. For JVT-G012, an improvement up to 0.42 dB is obtained while the average rate mismatch is reduced by 70%. 1.