gebhart/patrepeval huggingface dataset:
Abstract NTOC-087: DYNAMIC REPROGRAMMING OF THE KINOME OVERCOMES BET PROTEIN INHIBITION IN OVARIAN CANCER (2017)

Abstract High-grade serous ovarian carcinoma (HGS-OvCa) is the most common and deadly form of ovarian cancer, and currently lacks effective targeted therapies. Recently, proteins involved in chromatin remodeling such as the BET bromodomain protein BRD4 have emerged as an exciting new class of targets for the treatment of cancer. Targeted BRD4 inhibition has been shown to cause tumor regression and apoptosis in a number of cancers, including HGS-OvCa. Consequently, small molecule BET bromodomain inhibitors (BETi) are actively being pursued in clinical trials. In our preliminary studies, we discovered that the BET inhibitor JQ1 dramatically reduced MYC protein levels resulting in inhibited cell growth and survival in a panel of HGS-OvCa cell lines. Importantly, although JQ1 initially caused significant growth arrest and apoptosis, the majority of HGS-OvCa cell lines acquired drug resistance. Detailed molecular characterization of JQ1- resistant HGS-OvCa cells showed the return of MYC protein levels accompanied by elevated PI3K-AKT activity, suggesting the acquired resistance stems from activated kinase signaling. Our laboratory has designed a novel mass spectrometry approach that globally measures kinase activity to identify the kinase networks responsible for drug resistance. Using this technology, we analyzed global kinase activity in JQ1-resistant cells and observed the activation of several receptor-tyrosine kinases (RTKs), including EGFR, FGFRs and IGF1R known to strongly drive PI3K-AKT pro-survival signaling pathways. These findings suggest that BETi therapies may have limited success as single agent therapies due to “adaptive kinome reprogramming” and will likely require combination strategies involving inhibitors targeting protein kinases and BET bromodomain proteins. Citation Format: Alison M. Kurimchak, Claude Shelton, Kelly E. Duncan, Katherine J. Johnson, Jennifer Brown, Shane O'Brien, Rashid Gabbasov, Lauren S. Fink, Yuesheng Li, Nicole Lounsbury, Magid Abou-Gharbia, Wayne E. Childers, Denise C. Connolly, Jonathan Chernoff, Jeffrey R. Peterson, James S. Duncan. DYNAMIC REPROGRAMMING OF THE KINOME OVERCOMES BET PROTEIN INHIBITION IN OVARIAN CANCER [abstract]. In: Proceedings of the 11th Biennial Ovarian Cancer Research Symposium; Sep 12-13, 2016; Seattle, WA. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(11 Suppl):Abstract nr NTOC-087.
Curing behavior of liquid crystalline epoxy/DGEBA blend (2007)

Abstract The effect of liquid crystalline epoxy (LCE) resin on the curing behavior and thermomechanical properties of diglycidylether of bisphenol A (DGEBA) was investigated. LCE was blended with DGEBA and curing behavior of the blend was studied according to LCE content in the blend. Curing of DGEBA was accelerated and thermomechanical properties of DGEBA were considerably improved by the addition of LCE, which acted as a molecular reinforcement. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007
Characterization of fine-grain piezoceramic stack actuators (2001)

Samples of fine grain piezoelectric ceramics (less than or equal to 1 micrometers ) exhibit increased mechanical strength and improved machinability over conventional materials, which should result in actuators which have increased reliability with fewer rejected parts. The focus of the work presented here is to compare the properties of several fine grain and conventional actuators provided by TRS Ceramics. Specimens are constructed of TRS200 (a PZT-5A or DOD Type II equivalent material) and TRS600 (a PZT-5H or DOD Type VI equivalent material). All of the actuators consist of ceramic wafers bonded together with electrodes between them to form a stack. Several actuator overall dimensions and two wafer thicknesses (250 micrometers and 500 micrometers ) are investigated as well as material which has been subjected to hot isopress. The two main figures of merit in the stack actuator comparisons are free strain and blocked stress. Strain and stress loops are measured under a variety of field levels, including negative fields up to the coercive limit (full butterfly loops were not performed). Also compared are values of energy density and hysteresis in the strain, stress and electric displacement vs. field loops. Stack longevity is addressed through duration tests in which stacks are used to drive representative mechanical impedance for an extended period. Results show that fine grain stacks completed 10<SUP>9</SUP> continuous actuation cycles with no sign of performance degradation.
Source Error-Projection for Sample Selection in Phrase-Based SMT for Resource-Poor Languages (2011)

The unavailability of parallel training cor-pora in resource-poor languages is a ma-jor bottleneck in cost-effective and rapid deployment of statistical machine transla-tion (SMT) technology. This has spurred significant interest in active learning for SMT to select the most informative sam-ples from a large candidate pool. This is especially challenging when irrelevant outliers dominate the pool. We propose two supervised sample selection methods, viz. greedy selection and integer lin-ear programming (ILP), based on a novel measure of benefit derived from error anal-ysis. These methods support the selec-tion of diverse and high-impact, yet rel-evant batches of source sentences. Com-parative experiments on multiple test sets across two resource-poor language pairs (English-Pashto and English-Dari) reveal that the proposed approaches achieve BLEU scores comparable to the full sys-tem using a very small fraction of all avail-able training data (ca. 6 % for E-P and 13% for E-D). We further demonstrate that the ILP method supports global constraints of significant practical value. 1
ChemInform Abstract: Aldol Reactions of Ketal‐Protected Tartrate Ester Enolates. Asymmetric Syntheses and Absolute Stereochemical Assignments of Phospholipase A2 Inhibitors Cinatrin C1 and C3. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Production of Ultrafine-Grained Aluminum Alloys in Upsized Sheets Using Process of Incremental Feeding High-Pressure Sliding (IF-HPS) (2023)

This study introduces a process of severe plastic deformation (SPD) called incremental feeding high-pressure sliding (IF-HPS) where significant grain refinement is possible in an enlarged sheet area. The IF-HPS process is applied to Al alloys such as A1050, A3105, A5052 and A5182. The grain sizes were refined to the submicrometer ranges and the tensile strength increased to almost twice as much as the annealed states. The conditions for the IF-HPS process are optimized so that the tensile strength remains high without initiation of cracks. The process conditions are also investigated to achieve homogeneous development of the tensile properties throughout the processed sheets. It is demonstrated that the IF-HPS process is useful to extend the SPD-processed area without increasing the machine capacity while maintaining enhanced mechanical properties.
Low temperature phases of interacting fermions in two dimensions (2011)

This thesis is not available on this repository until the author agrees to make it public. If you are the author of this thesis and would like to make your work openly available, please contact us: thesis@repository.cam.ac.uk.
HyperBlock Floating Point: Generalised Quantization Scheme for Gradient and Inference Computation (2023)

Prior quantization methods focus on producing networks for fast and lightweight inference. However, the cost of unquantised training is overlooked, despite requiring significantly more time and energy than inference. We present a method for quantizing convolutional neural networks for efficient training. Quantizing gradients is challenging because it requires higher granularity and their values span a wider range than the weight and feature maps. We propose an extension of the Channel-wise Block Floating Point format that allows for quick gradient computation, using a minimal amount of quantization time. This is achieved through sharing an exponent across both depth and batch dimensions in order to quantize tensors once and reuse them during backpropagation. We test our method using standard models such as AlexNet, VGG, and ResNet, on the CIFAR10, SVHN and ImageNet datasets. We show no loss of accuracy when quantizing AlexNet weights, activations and gradients to only 4 bits training ImageNet.
Improving Dynamic Performance of Low-Inertia Systems Through Eigensensitivity Optimization (2021)

An increasing penetration of renewable generation has led to reduced levels of rotational inertia and damping in the power network. The consequences are higher vulnerability to disturbances and deterioration of the dynamic response of the system. To overcome these challenges, novel converter control schemes that provide virtual inertia and damping have been introduced, which raises the question of optimal distribution of such devices throughout the network. This paper presents a comprehensive framework for performance-based allocation of virtual inertia and damping to the converter-interfaced generators in a detailed low-inertia system. This is achieved through an iterative, eigensensitivity-based optimization algorithm that determines the optimal controller gains while simultaneously preserving small-signal stability and ensuring that the damping ratio and frequency response after disturbances are kept within acceptable limits. Two conceptually different problem formulations are presented and validated on a modified version of the well known Kundur's two-area system as well as a larger 59-bus South-East Australian network.
Isolation and chemical analyses of nonfermented fiber fractions of oat hulls and cottonseed hulls. (1991)

The purpose of this study was to isolate, using both in situ and in vivo methodology, the nonfermented fiber fraction of oat hulls (OH) and cottonseed hulls (CSH) and to compare the concentrations of alkali-labile phenolic monomers, nitrobenzene oxidizable phenolic monomers, and neutral monosaccharides, as well as the cross polarization/magic angle spinning (CP/MAS) carbon-13 (13C) nuclear magnetic resonance (NMR) spectra, of the nonfermented fraction with the original OH or CSH. The in situ isolation procedure involved a 30-h ruminal pretreatment and an 8-h acid:pepsin pretreatment followed by 1 to 7 additional days of incubation in the rumen. Fractions not fermented in vivo were isolated from duodena, ileal, and fecal material obtained from a site and extent of digestion trial in which these byproducts were fed to sheep at 80% of the diet (as-fed basis) and they represented the sole source of dietary fiber. Based on nonfermented fraction composition, both in situ and in vivo, all components analyzed were degraded to some extent. Also, all components present in original byproduct material were present in both the in situ and in vivo nonfermented fractions. Based on NMR analysis, cellulose crystallinity did not change during either long-term in situ or in vivo fermentation. However, CSH cellulose was more crystalline than that of OH. The ADL content of OH and CSH was 6.1% and 19.4%, respectively, and very little (15%) of the ADL disappeared during either in situ or in vivo fermentation. Much of the p-coumaric and ferulic acid of OH, associated with the cell wall matrix as lignin-carbohydrate and phenolic-carbohydrate complexes, was recovered in the fermented fractions. Data are interpreted to indicate that lignin encrustation and cellulose crystallinity are factors affecting CSH fermentation. Lignin encrustation and the presence of lignin-carbohydrate/phenolic-carbohydrate complexes are factors that inhibit OH fermentation.
High Performance AlGaN/GaN HFETs for RF Applications (2006)

Abstract not Available.
Epistemic Plan Recognition (2020)

The plan recognition task is to infer an actor's plan and goal given observations about its behavior. We submit that in some cases, for plan recognition to be effective and complete, it must appeal to a notion of epistemics to i) recognize epistemic goals, where the actor is trying to achieve some state of knowledge or belief; and ii) model the observer, and its knowledge of the actor, as first class elements of the plan recognition process. To this end, we formalize the notion of Epistemic Plan Recognition, which builds on two growing areas of research: epistemic planning and plan recognition. Our epistemic plan recognition specification appeals to an epistemic logic framework to represent agent beliefs. To realize our specification, we cast the epistemic plan recognition problem as an epistemic planning problem, whose solutions can be generated using existing epistemic planning tools. Finally, we evaluate our approach by utilizing and comparing existing epistemic planners on a diverse set of epistemic plan recognition problems.
Wide Range Achievement Test in Autism Spectrum Disorder: Test-Retest Stability (2015)

The principal goal of this descriptive study was to establish the test-retest stability of the Reading, Spelling, and Arithmetic subtest scores of the Wide Range Achievement Test (WRAT-3) across two administrations in individuals with autism spectrum disorder. Participants (N = 31) were males ages 6-22 years (M = 15.2, SD = 4.0) who were part of a larger ongoing longitudinal study of brain development in children and adults with autism spectrum disorder (N = 185). Test-retest stability for all three subtests remained consistent across administration periods (M = 31.8 mo., SD = 4.1). Age at time of administration, time between administrations, and test form did not significantly influence test-retest stability. Results indicated that for research involving individuals with autism spectrum disorder with a full scale intelligence quotient above 75, the WRAT-3 Spelling and Arithmetic subtests have acceptable test-retest stability over time and the Reading subtest has moderate test-retest stability over time.
Party-people and local governance in an Indian state: a longitudinal study on the roots of electoral violence (2020)

West Bengal, in comparison to other states of India, witnesses large-scale political violence throughout the year which, however, sees an upswing particularly during the time of elections. Nonetheless, apart from a few sporadic mentions, such violence is yet to get scholarly attention. Based on my longitudinal ethnography (2008–2017) in four Gram Panchayats – the lowest to the three-tier local governance system, I show the ways in which political polarization and violence occupy a dominant position in everyday village life of the state. I show that while domains of dominance-subordination and hate speech shape much of the discursive spheres of the state, people, through a variety of formal and informal channels, tend to depend on political party and panchayat. Such politico-economic dependence, development of hooligan dominated political control, and continuation of violence through direct and subtler means are some of the major roots of violence.
Analysis of 3 gamma/2 gamma ratio in the measurement of positron annihilation Doppler-broadening spectroscopy (2006)

Doppler-broadening slow positron annihilation spectroscopy is used to measure the concentration, spatial distribution, and size of open-volume defects in surface and interface of material. In this method, the quantitative evaluation is generally carried out with the line shape parameter S and W, but sometimes the parameters provide some finite information. For example, if positron and electron form positronium (include o-Ps and p-Ps) in material, the parameters S and W may provide little information about positronium even complicate the analyses. A parameter I-3 gamma, defined as o-Ps self-decay intensity, was used to analyze Ag layer capped and non-capped silica aerogel by slow positron annihilation Doppler-broadening spectroscopy. The result shows that I-3 gamma can provide more information for researching mesoporous material and nanometer film.
Characterization of a major fibroblast cell surface glycoprotein (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of a major fibroblast cell surface glycoproteinKenneth M. Yamada, David H. Schlesinger, Dorothy W. Kennedy, and Ira PastanCite this: Biochemistry 1977, 16, 25, 5552–5559Publication Date (Print):December 13, 1977Publication History Published online1 May 2002Published inissue 13 December 1977https://pubs.acs.org/doi/10.1021/bi00644a025https://doi.org/10.1021/bi00644a025research-articleACS PublicationsRequest reuse permissionsArticle Views70Altmetric-Citations138LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Validation of a Real-Time Reverse Transcriptase–PCR Assay for the Detection of H7 Avian Influenza Virus (2010)

This report describes the validation of an avian influenza virus (AIV) H7 subtype-specific real-time reverse transcriptase-PCR (rRT-PCR) assay developed at the Southeast Poultry Research Laboratory (SEPRL) for the detection of H7 AI in North and South American wild aquatic birds and poultry. The validation was a collaborative effort by the SEPRL and the National Veterinary Services Laboratories. The 2008 H7 rRT-PCR assay detects 10(1) 50% embryo infectious doses per reaction, or 10(3)-10(4) copies of transcribed H7 RNA. Diagnostic sensitivity and specificity were estimated to be 97.5% and 82.4%, respectively; the assay was shown to be specific for H7 AI when tested with > 270 wild birds and poultry viruses. Following validation, the 2008 H7 rRT-PCR procedure was adopted as an official U.S. Department of Agriculture procedure for the detection of H7 AIV. The 2008 H7 assay replaced the previously used (2002) assay, which does not detect H7 viruses currently circulating in wild birds in North and South America.
1188-P: Glycemic Efficacy of Sitagliptin in East Asian Populations: A Pooled Analysis (2019)

The efficacy/safety of sitagliptin (SITA) has been studied in global populations. This post hoc pooled analysis of 20 placebo (PBO)-controlled studies reports data collected specifically in East Asian populations (EAP). Results were summarized for overall EAP and subgroups defined by geography. Change from baseline in A1C was analyzed at week 12 using ANCOVA model with treatment, study, and baseline A1C terms. A1C values following initiation of rescue medication were excluded. Missing A1C values were imputed using LOCF method. Baseline characteristics were generally balanced across treatments (mean A1C 8.5%, age 55-56 years, BMI 25 kg/m2, FPG 177-179 mg/dL, duration T2D 7-8 years). After 12 weeks of SITA, all populations showed significant A1C reductions vs. PBO (Table) and the largest PBO-adjusted reduction was seen in the Japan subgroup. PBO treatment was associated with reductions in A1C in China Mainland (CM), but with increases in Japan. The percentages of SITA-treated pts with A1C &amp;lt;7% were 18.9%, 14.2%, 37.4% and 30.4% for overall EAP, CM, Japan and Other East Asian subgroups, respectively (all p&amp;lt;0.001 vs. PBO). The incidences of hypoglycemia (i.e., symptomatic/asymptomatic) were 13/981 [1.3%] and 5/816 [0.6%] for SITA and PBO, respectively. These results are consistent with previous findings in global populations. Disclosure J.M. Conceicao: Employee; Self; Merck Sharp &amp; Dohme Corp. Stock/Shareholder; Self; Merck Sharp &amp; Dohme Corp. C.D. Gonzalez: Employee; Self; Merck &amp; Co., Inc. Stock/Shareholder; Self; Merck &amp; Co., Inc. S.S. Engel: Employee; Self; Merck &amp; Co., Inc. Stock/Shareholder; Self; Merck &amp; Co., Inc. J. Ahn: Employee; Self; Merck Sharp &amp; Dohme Corp. Stock/Shareholder; Self; Merck Sharp &amp; Dohme Corp. S. Tokita: Employee; Self; Merck Sharp &amp; Dohme Corp. Stock/Shareholder; Self; Merck Sharp &amp; Dohme Corp. Y. Zhang: Employee; Self; Merck Sharp &amp; Dohme Corp. R. Zhang: Employee; Self; Merck Sharp &amp; Dohme Corp. R.L. Lam: Employee; Self; Merck &amp; Co., Inc. A. Pong: None. Funding Merck &amp; Co., Inc.
Crosstalk Suppression of Corrugated Waveguides in an Optical Phased Array Using 2D Photonic Crystal Slab (2013)

A 16 element corrugated waveguide array fabricated in a single step is demonstrated to achieve over 15° of steering via wavelength tuning. Optical crosstalk suppression is achieved by inserting 2D photonic crystal between array elements.
Extracellular vesicles released from chronic lymphocytic leukemia cells exhibit a disease relevant mRNA signature and transfer mRNA to bystander cells (2016)

B-cell chronic lymphocytic leukemia (CLL) is characterized by the clonal accumulation of mature apoptosis-resistant tumor cells in lymphoid tissues and the peripheral blood. Recently genetic and epigenetic aberrations associated with the pathogenesis, the progression, and the response to therapy
SERUM METAL LEVELS FOR THE DIAGNOSIS OF ADVERSE LOCAL TISSUE REACTIONS IN METAL-ON-POLYETHYLENE TOTAL HIP ARTHROPLASTY (2017)

Recently, corrosion at the head-neck junction in metal-on-polyethylene bearing total hip arthroplasty (THA) has been recognized as a cause of adverse local tissue reactions (ALTR). Serum metal levels have been advocated as a tool for the diagnosis of ALTR, however no prior studies have specifically examined their utility. The purpose of this study was to determine the optimal cut-off values for serum cobalt and chromium in diagnosing ALTR after metal-on-polyethylene bearing THA. We reviewed 447 consecutive patients with serum metal levels tested at our institution and identified 62 with a metal-on-polyethylene bearing who had axial imaging or underwent reoperation to confirm the presence or absence of ALTR. Receiver operating characteristic curves were produced to identify cut-off thresholds to optimize sensitivity and diagnostic test performance was characterized. 42 Of the 62 patients (66%) were positive for an ALTR. The best test for the diagnosis of ALTR was the serum cobalt level (area under the curve [AUC]=99%). A threshold cut-off of ≥ 1.0 ng/ml had a sensitivity of 100%, specificity of 90%, positive predictive value (PPV) of 96%, and negative predictive value (NPV) of 100%. Serum chromium levels were also diagnostic (AUC=87%). A threshold cut-off of ≥ 0.15 ng/ml had a sensitivity of 100%, specificity of 50%, PPV of 81%, and NPV of 100%. Finally, serum cobalt to chromium ratio was also helpful for diagnosis (AUC=90%). A threshold cut-off of 1.4 for the cobalt to chromium ratio offered a sensitivity of 93%, specificity of 70%, PPV of 87%, and NPV of 82%. Measurement of serum cobalt with a threshold value of 1.0 ng/ml in our experience is the best test for identifying the presence of ALTR in patients with a metal-on-polyethylene THA. Measurement of chromium and the ratio of cobalt to chromium are also of value.