gebhart/patrepeval huggingface dataset:
Estimating Poisson’s ratio of a free, rectangular panel using video-based modal analysis (2018)

Recent work has shown that the Poisson’s ratio of an isotropic material can be determined using the anticlastic curvature that exists in certain mode shapes of a free, rectangular panel of that material. The shapes must be measured experimentally in order to determine the curvature that exists. The curvature is then related to Poisson’s ratio based on a relationship that depends on thickness and length-to-width ratio. For accurate determination of the anticlastic curvature, high spatial resolution is required. In this paper, high speed video is used to experimentally measure the mode shapes of a free, rectangular panel. The spatial resolution achieved is much higher than that obtained using traditional methods due to the inherent resolution of the camera. The high-speed video results are demonstrated and compared to modes using traditional modal techniques. The Poisson’s ratio is then computed and found to agree well with published values.
Complex quinuclidines (1-azabicyclo[2.2.2]octanes) from sugars: synthesis of (1α,3α,4α,5α)-quinuclidine-3,5-diol fromD-glucose (1989)

G. W. J. Fleet, C. J. Mathews, J. A. Seijas, M. P. V. Tato and D. J. Brown, J. Chem. Soc., Perkin Trans. 1, 1989, 1067 DOI: 10.1039/P19890001067
Transcription of the oprF Gene of Pseudomonas aeruginosa Is Dependent Mainly on the SigX Sigma Factor and Is Sucrose Induced (2012)

ABSTRACT The OprF porin is the major outer membrane protein of Pseudomonas aeruginosa . OprF is involved in several crucial functions, including cell structure, outer membrane permeability, environmental sensing, and virulence. The oprF gene is preceded by the sigX gene, which encodes the poorly studied extracytoplasmic function (ECF) sigma factor SigX. Three oprF promoters were previously identified. Two intertwined promoters dependent on σ 70 and SigX are located in the sigX - oprF intergenic region, whereas a promoter dependent on the ECF AlgU lies within the sigX gene. An additional promoter was found in the cmpX - sigX intergenic region. In this study, we dissected the contribution of each promoter region and of each sigma factor to oprF transcription using transcriptional fusions. In Luria-Bertani (LB) medium, the oprF -proximal region ( sigX - oprF intergenic region) accounted for about 80% of the oprF transcription, whereas the AlgU-dependent promoter had marginal activity. Using the sigX mutant PAOSX, we observed that the SigX-dependent promoter was largely predominant over the σ 70 -dependent promoter. oprF transcription was increased in response to low NaCl or high sucrose concentrations, and this induced transcription was strongly impaired in the absence of SigX. The lack of OprF itself increased oprF transcription. Since these conditions led to cell wall alterations, oprF transcription could be activated by signals triggered by perturbation of the cell envelope.
MicroRNA-486 regulates normal erythropoiesis and enhances growth and modulates drug response in CML progenitors (2014)

MicroRNAs (miRNAs) are key regulators of hematopoietic cell differentiation and may contribute to altered growth of leukemic stem cells. Using microarray-based miRNA profiling, we found that miRNA 486 (miR-486) is significantly upregulated in chronic myeloid leukemia (CML) compared with normal CD34(+) cells, particularly in the megakaryocyte-erythroid progenitor population. miR-486-5p expression increased during erythroid differentiation of both CML and normal CD34(+) cells. Ectopic miR-486-5p expression enhanced in vitro erythroid differentiation of normal CD34(+) cells, whereas miR-486-5p inhibition suppressed normal CD34(+) cell growth in vitro and in vivo and inhibited erythroid differentiation and erythroid cell survival. The effects of miR-486-5p on hematopoietic cell growth and survival are mediated at least in part via regulation of AKT signaling and FOXO1 expression. Using gene expression and bioinformatics analysis, together with functional screening, we identified several novel miR-486-5p target genes that may modulate erythroid differentiation. We further show that increased miR-486-5p expression in CML progenitors is related to both kinase-dependent and kinase-independent mechanisms. Inhibition of miR-486-5p reduced CML progenitor growth and enhanced apoptosis following imatinib treatment. In conclusion, our studies reveal a novel role for miR-486-5p in regulating normal hematopoiesis and of BCR-ABL-induced miR-486-5p overexpression in modulating CML progenitor growth, survival, and drug sensitivity.
Manipulation of Thermoresponsive Polymers Using Biomolecules (2023)

Thermoresponsive polymers (TRPs) have attracted considerable interest in the scientific community because of their potential applications in sensors, gels, drug delivery devices, biotechnology, and pharmacology. Certain biomolecules alter the phase transition behavior of TRPs by acting as external biological stimuli. Herein, we describe recently reported results and trends for TRP/biomolecule mixed systems in which biological stimuli modulate temperature-dependent polymer transitions and reviewed studies related to protein–polymer assembly formation, interactions, and temperature-dependent protein adsorption. Modifying polymer properties in response to biomolecules, which are inherently present in the human body, designs polymeric biomaterials with envisaged applications. We hope this review sheds light on scientific problems concerning biomolecule–polymer mixed systems and helps in designing next-generation “smart” polymers.
Putting the ‘HAT’ back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions (2009)

Decreased histone acetyltransferase activity and transcriptional dysfunction have been implicated in almost all neurodegenerative conditions. Increasing net histone acetyltransferase activity through inhibition of the histone deacetylases (HDACs) has been shown to be an effective strategy to delay or halt progression of neurological disease in cellular and rodent models. These findings have provided firm rationale for Phase I and Phase II clinical trials of HDAC inhibitors in Huntington's disease, spinal muscular atrophy, and Freidreich's ataxia. In this review, we discuss the current findings and promise of HDAC inhibition as a strategy for treating neurological disorders. Despite the fact that HDAC inhibitors are in an advanced stage of development, we suggest other approaches to modulating HDAC function that may be less toxic and more efficacious than the canonical agents developed so far.
Apparatus and method for using radar to evaluate wind flow fields for wind energy applications (2023)

The present invention provides an apparatus and method for obtaining data to determine one or more characteristics of a wind flow field using one or more radars. Data is collected from the one or more radars, and analyzed to determine the one or more characteristics of the wind flow field. The one or more radars are positioned to have a portion of the wind flow field within a scanning sector of the one or more radars.
In-Vivo Whole Bladder Response to Anticholinergic and Musculotropic Agents in Spinal Cord Injured Rats (1997)

The purpose of this study was to compare the effect on urodynamic parameters of anticholinergic and musculotropic agents in sham injured and spinal cord injured (SCI) rats. A standard rat SCI model induced by impact trauma was employed. Cystometrograms were performed under urethane anesthesia four weeks after SCI. Bladder capacity and voiding pressure were determined at the point of micturition monitored urodynamically and visually. The effect of oxybutynin chloride (0.01-0.1 mg/kg), propantheline bromide (0.05-0.5 mg/kg) and flavoxate hydrochloride (0.1-1.0 mg/kg) were assessed independently in sham injured and SCI rats (n = 10 in each group). Bladder capacities were 0.6 +/- 0.2 and 7.1 +/- 1.6 ml in sham and SCI rats (p < 0.01), respectively. Maximal filling pressure was 17.5 +/- 5 mmHg in sham and 25 +/- 5 mmHg in SCI rats (p < 0.05). Bladder capacity increased with all three medications. Administration of oxybutynin, propantheline and flavoxate in sham rats resulted in bladder capacities of 0.88 +/- 0.3, 0.71 +/- 0.3 and 0.8 +/- 0.2 ml, respectively (p < 0.01). In SCI rats, these drugs resulted in bladder capacities of 9.8 +/- 1.1, 7.9 +/- 1.3 and 8.8 +/- 2.0 ml, respectively (p < 0.01). No significant change in maximum filling pressure occurred. We conclude that anticholinergic and musculotropic agents caused a similar increase in bladder capacity in both sham and SCI rats. Oxybutynin enhanced bladder capacity more than propantheline or flavoxate.
Public key management scheme with certificate management node for wireless ad hoc networks (2006)

Abstract. An authentication technique is an important issue for a wireless ad hoc network that is composed with unknown nodes. The self-organized public key management scheme that each node creates and manages certificates by itself has been proposed for the network that does not connect to the Internet with a certificate authority. However, it needs large time and loads heavy traffic to collect all certificates in the network. In this paper, we propose public key management scheme with repository management node that collects certificates of each node in its power range. This proposed scheme consists of selecting certificate management node (CMN) and clustering techniques. It can reduce the time to collect certificates from the CMN when normal nodes access to the CMN. Furthermore, our proposed scheme can reduce memory and traffic loads because normal nodes neither have all certificates nor exchange repositories each other. By a computer simulation, we evaluate average traffic and an amount of memory consumption and show that the proposed scheme can reduce the both of them than conventional schemes.
Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis - a double-blind comparison with sustained release mesalazine (2010)

HMPL-004 may be an efficacious alternative to mesalazine in ulcerative colitis.
Impedance Compressing Matching Network Based on Two-Port Network Analysis for Wireless Power Transfer System (2021)

This article proposes a new design method of impedance matching networks for wireless power transfer (WPT) systems. In WPT systems, the input impedance of resonator varies over a wide range rather than having a fixed value due to coupling variation. In conventional systems, tunable matching networks have been commonly used to match the variable impedance to a fixed impedance. Three-port impedance compression networks have also been proposed to eliminate the mechanical tuning processes. In this article, a two-port impedance compressing matching network (ICMN) is proposed that addresses the load variations without the need for any mechanical tuning. In impedance matching, a two-port network can have a low design degree-of-freedom for load variation. In order to overcome this limitation, this article analyzes the general model of a two-port network and proposes a systematic design procedure. The effectiveness of the proposed method is verified with a design example that constructs an ICMN <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> .
Nanostructured ZnS and CdS Films Synthesized using Layered Double Hydroxide Films as Precursor and Template (2009)

Anion exchange reactions in layered double hydroxide films (M(OH)(2-x)(NO(3))(x).mH(2)O) followed by solid state conversion reactions are shown to yield micrometer-sized unsupported metal sulfide (M = Zn, Cd) films with unique textured morphologies. The characteristic three-dimensional nanostructured film morphology and crystallinity of the initial films are retained in the metal sulfide films although these conversion reactions involve anion exchanges concomitant with significant rearrangements of the crystal structures. Surface areas of 42 m(2)/g for zinc sulfide and 50 m(2)/g for cadmium sulfide thin films are observed. These values correspond to an increase in surface area of 75% for the Zn(5)(OH)(8)(NO(3))(2).2H(2)O to zinc sulfide conversion, while the cadmium sulfide films exhibit more than three times the surface area of their precursor material, Cd(OH)(NO(3)).H(2)O. The three-dimensional morphology of the resulting films is thus observed to combine the physical properties of the bulk materials with the advantages of higher surface areas typically associated with nanostructured or porous materials. The layered double hydroxide materials used in this study to provide both structural and chemical templates were prepared using the mild conditions of a biologically inspired vapor-diffusion catalytic synthesis.
A Gene Related to Yeast HOS2 Histone Deacetylase Affects Extracellular Depolymerase Expression and Virulence in a Plant Pathogenic Fungus (2001)

Dipnath Baidyaroy, Gerald Brosch, Joong-hoon Ahn, Stefan Graessle, Sigrun Wegener, Nyerhovwo J. Tonukari, Oscar Caballero, Peter Loidl, Jonathan D. Walton, A Gene Related to Yeast HOS2 Histone Deacetylase Affects Extracellular Depolymerase Expression and Virulence in a Plant Pathogenic Fungus, The Plant Cell, Vol. 13, No. 7 (Jul., 2001), pp. 1609-1624
Optimization Models for Congestion Mitigation in Virtual Networks (2014)

Virtualization of network functions and services can significantly reduce capital and operational expenditures of telecommunication operators through the sharing of a single network infrastructure. However, the utilization of the same resources can increase their congestion due to the spatio-temporal correlation of traffic demands and computational loads. In this paper, we propose novel orchestration mechanisms to optimally control and reduce the resource congestion of a physical infrastructure based on the NFV paradigm. In particular, we formulate the network functions composition problem as a nonlinear optimization model to accurately capture the congestion of the physical resources. In order to meet both efficiency and load balancing goals of the physical operator, we introduce two variants of such model to minimize the total and the maximum congestion in the network. Our models allow us to efficiently compute the optimal solution in a short computing time. Numerical results, obtained with real ISP topologies and network instances, show that the proposed approach represents an efficient and practical solution to control the congestion in virtual networks. Furthermore, they indicate that a holistic approach that optimizes the virtual system by jointly considering all elements/components would further improve the performance.
Intracellular calcium waves in bone cell networks under single cell nanoindentation. (2006)

In this study, bone cells were successfully cultured into a micropatterned network with dimensions close to that of in vivo osteocyte networks using microcontact printing and self-assembled monolyers (SAMs). The optimal geometric parameters for the formation of these networks were determined in terms of circle diameters and line widths. Bone cells patterned in these networks were also able to form gap junctions with each other, shown by immunofluorescent staining for the gap junction protein connexin 43, as well as the transfer of gap-junction permeable calcein-AM dye. We have demonstrated for the first time, that the intracellular calcium response of a single bone cell indented in this bone cell network, can be transmitted to neighboring bone cells through multiple calcium waves. Furthermore, the propagation of these calcium waves was diminished with increased cell separation distance. Thus, this study provides new experimental data that support the idea of osteocyte network memory of mechanical loading similar to memory in neural networks.
Morphological Ensembles of N‐Doped Porous Carbon Derived from ZIF‐8/Fe‐Graphene Nanocomposites: Processing and Electrocatalytic Studies (2018)

Abstract Engineering the active site density of porous carbon catalysts for enhanced electrocatalytic activity is the current focus in the quest for economically viable fuel cells. Herein, we synthesise ZIF‐8/Fe‐graphene composites for the formation of N and Fe co‐doped carbon with diverse morphologies ranging from tubes and sheets to frameworks of carbon. A synthetic strategy involving the one pot synthesis of ZIF‐8 based composites is accomplished by the reaction of 2‐methylimidazole with mixed Zn/Fe salt solution containing graphene dispersions. The high temperature heat treatment of this precursor mix yielded micro‐meso porous architectures of N, Fe co‐doped carbon with dispersions of Fe/Fe 3 C. An onset potential value of 0.95 V and a half‐wave potential of 0.82 V coupled with excellent durability and stability in alkaline medium indicated improved electrocatalytic performances over its commercial Pt/C counterpart. The appreciable electrocatalytic properties of the synthesized carbon are attributed to its morphological diversity, hybrid structure, high N doping and its heteroporous characteristics. The dispersed Fe/Fe 3 C and FeNx sites facilitated enhanced oxygen adsorption and the graphene inclusions in the composite provided retention of high nitrogen contents.
Interleukin-1-dependent sequential chemokine expression and inflammatory cell infiltration in ischemia-reperfusion injury (2006)

IL-1-dependent inflammatory cascades, followed by inflammatory cell infiltration and subsequent tissue destruction, may affect pathogenesis of renal ischemia-reperfusion injury.
SVC bitstream adaptation in MPEG-21 multimedia framework (2006)

Scalable video coding (SVC) is the most promising video format for applications of collaborative communication. MPEG-21 standard has newly emerged to enable the interoperability of multimedia delivery in heterogeneous environments. In this paper we study adaptation of SVC bitstream in the context of MPEG-21 multimedia framework. For interfacing SVC bitstream with MPEG-21 based adaptation system, we propose three SVC specific adaptation operators. Based on our previous work with multidimensional video adaptation, we present an effective approach, using MPEG-21 DIA AdaptationQoS description tool, to model QoS control for SVC adaptation. Then we show how the operator values could be computed from that representation. For the actual adaptation at bitstream level, we propose a procedure to remove the unnecessary NAL units from an SVC bitstream. The result of this study enables QoS management of SVC streaming in an efficient and standardized manner.
Boratastilbene:  Synthesis, Structural Characterization, and Photophysics (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTBoratastilbene: Synthesis, Structural Characterization, and PhotophysicsBun Yeoul Lee, Shujun Wang, Markus Putzer, Glenn P. Bartholomew, Xianhui Bu, and Guillermo C. BazanView Author Information Department of Chemistry, University of California Santa Barbara, California 93106 Cite this: J. Am. Chem. Soc. 2000, 122, 16, 3969–3970Publication Date (Web):April 7, 2000Publication History Received8 November 1999Revised28 February 2000Published online7 April 2000Published inissue 1 April 2000https://pubs.acs.org/doi/10.1021/ja993930vhttps://doi.org/10.1021/ja993930vrapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views461Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Absorption,Absorption spectroscopy,Chemical structure,Ions,Sodium Get e-Alerts
Effect of the coordination geometry and of substituent shielding on the kinetics of ligand substitution in copper(II) chelates (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of the coordination geometry and of substituent shielding on the kinetics of ligand substitution in copper(II) chelatesHorst Elias, Christina Hasserodt-Taliaferro, Ludwig Hellriegel, Walter Schoenherr, and Klaus J. WannowiusCite this: Inorg. Chem. 1985, 24, 20, 3192–3198Publication Date (Print):September 1, 1985Publication History Published online1 May 2002Published inissue 1 September 1985https://pubs.acs.org/doi/10.1021/ic00214a022https://doi.org/10.1021/ic00214a022research-articleACS PublicationsRequest reuse permissionsArticle Views144Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope–specific plasma cells and humoral immunity in nonhuman primates (2020)

Our study describes robust and durable induction of HIV-1–specific antibody as well as germinal center and plasma cellular responses in rhesus macaques.
A structural change of the plasma membrane induced by oncogenic viruses: quantitative studies with the freeze-fracture technique. (1975)

In BHK21 hamster cells a significant increase in density of intramembranous particles occurs in freeze-fractured plasma membranes after transformation by hamster sarcoma and polyoma viruses. A similar change has been observed in chick embryo cells infected and transformed by a mutant of Rous sarcoma virus thermosensitive for transformation, at both permissive and nonpermissive temperatures. There is also an increase in particle density in chick cells infected with the Rous-associated avian leukosis virus type 1. The newly appeared particles may represent the insertion of new proteins in hydrophobic regions of plasma membrane, in response to the action of oncogenic viruses.
High data rate signal integrity in micron-scale silicon ring resonators (2006)

A ring resonator with a FWHM of 0.095 nm (11.6 GHz) is experimentally measured to have a 1.4 dB power penalty for a 10 Gbps NRZ OOK signal, due to spectral distortions. Numerical simulations match these results.