gebhart/patrepeval huggingface dataset:
Boron-Assisted Transformation to Rod-Like Graphitic Carbons from Multi-Walled Carbon Nanotubes in Boron-Mixed Multi-Walled Carbon Nanotube Solids (2011)

We produced boron-mixed multi-walled carbon nanotube solids (B-mixed MWCNT solids) by heating and pressing the powder of purified MWCNTs mixed with 1, 5, and 10 wt % boron in the temperature range 1400-1800 °C every 200 °C under a constant pressure of 20 MPa in vacuo, and investigated the influence of boron addition on nanotube structure and the mechanical and electrical properties of the resulting B-mixed MWCNT solids. The structure of the prepared material was characterized by scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy, high-resolution transmission electron microscopy-electron energy loss spectroscopy, Raman scattering spectroscopy, and X-ray diffraction, and their mechanical properties and conductivity were measured using a mechanical and Vickers indentation tester and an electric resistor, respectively. It is notable that part of the nanotubes in the B-mixed MWCNT solids solidified at 1800 °C had dramatically changed into rod-like graphitic carbons (RLGCs). The occupancy distribution of RLGCs increased with increasing boron contents. However, boron was not detected in the energy-loss near-edge structure spectrum of RLGCs. Furthermore, RLGCs were not observed in the boron-unmixed sample treated with the same solidified condition, indicating that adding boron causes a remarkable ability to transform the phase of MWCNT. Transformation from MWCNTs to RLGCs resulted in increased specific bending strength and modulus, Vickers hardness, and electrical conductivity of B-mixed MWCNT solids with increasing boron content and solidified temperature.
Comprehensive T cell repertoire characterization of non-small cell lung cancer (2020)

Immunotherapy targeting T cells is increasingly utilized to treat solid tumors including non-small cell lung cancer (NSCLC). This requires a better understanding of the T cells in the lungs of patients with NSCLC. Here, we report T cell repertoire analysis in a cohort of 236 early-stage NSCLC patients. T cell repertoire attributes are associated with clinicopathologic features, mutational and immune landscape. A considerable proportion of the most prevalent T cells in tumors are also prevalent in the uninvolved tumor-adjacent lungs and appear specific to shared background mutations or viral infections. Patients with higher T cell repertoire homology between the tumor and uninvolved tumor-adjacent lung, suggesting a less tumor-focused T cell response, exhibit inferior survival. These findings indicate that a concise understanding of antigens and T cells in NSCLC is needed to improve therapeutic efficacy and reduce toxicity with immunotherapy, particularly adoptive T cell therapy.
Recombinant type 5 adenoviruses expressing bovine parainfluenza virus type 3 glycoproteins protect Sigmodon hispidus cotton rats from bovine parainfluenza virus type 3 infection (1995)

Cotton rats were used to study the replication and pathogenesis of bovine parainfluenza virus type 3 (bPIV3) and to test the efficacy of the F and HN glycoproteins in modulating infection. In vitro cultures of cotton rat lung cells supported the growth of bPIV3 as shown by virus recovery, immunofluorescence, immunoprecipitation, and syncytium induction. Intranasal (i.n.) inoculation of cotton rats with 10(7) PFU resulted in peak recovery of virus after 2 days (8 x 10(4) PFU/g of lung tissue) and significant bronchiolitis with lymphocyte infiltration 5 to 7 days postinfection. Immunohistochemical staining of lungs and trachea demonstrated that virus antigen-positive cells increased in frequency over the course of infection to a maximum on day 5. Serum antibody responses were evaluated by enzyme-linked immunosorbent assays (ELISA), hemagglutination inhibition (HAI), and serum neutralization (SN). Following a single i.n. inoculation, serum antibody levels were 1/40,960, 1/32, and 1/80, as detected by ELISA, HAI, and SN, respectively. When an intramuscular inoculation of 10(7) PFU was administered 10 days prior to the i.n. inoculation, a secondary response which resulted in an ELISA titer of 1/163,000, an HAI titer of 1/640, and an SN titer of 1/512 was induced. IN inoculation of recombinant adenoviruses type 5 containing the bPIV3 F or HN protein or a combination of the two viruses protected cotton rats from bPIV3 challenge. Protection was evaluated serologically by ELISA, HAI, and SN titers, histopathology, immunohistochemistry, and virus recovery.
Cross-Linked Ultrathin Polyurea Films via Molecular Layer Deposition (2013)

Ultrathin cross-linked polymer thin films are highly desirable materials because of their important roles in many applications. However, they are difficult and challenging to fabricate. Here we report a one-step process for depositing cross-linked polyurea thin films using a vapor-phase molecular layer deposition (MLD) technique. 1,4-Diisocyanatobutane and a series of different multiamines, including diethylenetriamine, triethylenetetramine, and tris(2-aminoethyl)amine, were used to grow polyurea MLD films via urea-coupling reactions. The deposited cross-linked polyurea films exhibit characteristic MLD film growth behaviors, such as constant growth rates, infrared absorption by expected urea modes, and stoichiometric chemical compositions. More importantly, the cross-linking is shown to be capable of improving the film properties. Based on cross-linking, the thin film density can be increased by approximately 50%. In addition, the film decomposition temperature is increased by about 30 °C, suggesting an enhanced thermal stability of the cross-linked ultrathin polyurea films.
Plasmin and Epidermal Growth Factor in the Tear Fluid of Contact-Lens Wearers: Effect of Wearing Different Types of Contact Lenses and Association with Clinical Findings (1990)

The concentrations of plasmin and epidermal growth factor were determined in tear fluid (TF) samples from wearers of different types of contact lenses (CLs) during and after cessation of CL wear (CLW). TF samples of 50 healthy eyes served as controls. The plasmin concentrations in the control group (0.4 +/- 0.1 microgram/ml; mean +/- SEM) were significantly lower (p less than 0.001) than in the group of soft CL (SCL) wearers during CLW (1.2 +/- 0.2 microgram/ml). Cessation of CLW led to a decrease in TF plasmin concentrations from 1.2 +/- 0.2 to 0.6 +/- 0.1 micrograms/ml in the group of SCL wearers (p less than 0.001), from 1.5 +/- 1.1 to 0.3 +/- 0.2 micrograms/ml in the group of extended-wear SCL wearers (p greater than 0.05) and from 0.4 +/- 0.3 to 0.0 +/- 0.0 microgram/ml in the group of gas-permeable CL wearers (p greater than 0.05). After CLW cessation, TF plasmin levels of CL wearers did not differ from those of controls. The occurrence of plasmin in TF was associated with a higher degree of corneal neovascularization and with the presence of limbal injection. The concentrations of epidermal growth factor in TF were not significantly altered by the discontinuation of CLW.
General Formulation for Modeling Bandpass Filters with Finite Quality Factors and Resistive Couplings (2008)

Insertion loss can considerably affect the shape of bandpass filters. This effect can be broken down into two different aspects: the finite quality factor of each cavity and the resistive coupling between resonators. This paper presents a general model that can be used to predict the behavior of bandpass filters presenting insertion losses. A technique to extract the required values is also presented for two coupled resonators and the source/load coupling. Finally an inductive post rectangular waveguide bandpass filter is modeled with the proposed technique. The results agree with the full wave simulation obtained from a commercial package.
Enhanced lithographic resolution using longitudinal polarization state of light (2015)

Laser direct-writing is an important technique for the fabrication of complex patterns. There is a continuous need for structures with increasingly small features, i.e., enhanced resolution. Focused radially polarized light is known to exhibit a narrow longitudinal polarization component. Here, a proof-of-concept is shown of enhanced resolution through polarization-selectivity by the selective recording of the longitudinal polarization component in a polarization-selective homeotropic and smectic B photoresist. The full-width-at-half-maximum (FWHM) of the fabricated spots in the polarization-selective resist is up to 56% smaller compared to the FWHM of the same spot in a photoresist that is not polarization-selective, which supports simulations that predict a theoretical maximum reduction of 62%.
Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction (2015)

The presented insight into post-MI bone marrow activation identifies a mechanistic target for muting inflammation in the ischemically damaged heart.
Supplementary Figure Legends 1-3 from Antitumor Activity of the Hsp90 Inhibitor IPI-504 in HER2-Positive Trastuzumab-Resistant Breast Cancer (2023)

Supplementary Figure Legends 1-3 from Antitumor Activity of the Hsp90 Inhibitor IPI-504 in HER2-Positive Trastuzumab-Resistant Breast Cancer
Next Generation Nuclear Plant Materials Research and Development Program Plan, Revision 3 (2006)

2006 update (Revision 3) of the NGNP Materials Research and Development Program Plan
Cloning, functional characterization, and localization of a rat renal Na+-dicarboxylate transporter (1998)

We report here the isolation, functional characterization, tissue distribution, and membrane localization of rat renal Na+-dicarboxylate transporter (rNaDC-1). rNaDC-1 consists of 2,245 nucleotides, and the deduced amino acid sequence showed 73% and 75% identity to rabbit and human NaDC-1, respectively. When expressed in Xenopus laevis oocytes, rNaDC-1 mediated sodium-dependent uptake of di- and tricarboxylates. Substrates of rNaDC-1 evoked inward currents in oocytes expressed with rNaDC-1; succinate, alpha-ketoglutarate, and glutarate were relatively high-affinity substrates, and citrate was a low-affinity substrate of rNaDC-1. The coupling ratio of citrate to charge was determined to be 1:1 at pH 7.4; influx of one positive charge per citrate molecule suggests a symport of three Na+ with a divalent citrate. Expression of rNaDC-1 mRNA was detected in the kidney and the small and large intestines. Immunohistochemistry using polyclonal antibodies raised against the 14 amino acids at the COOH terminus of rNaDC-1 revealed that rNaDC-1 is localized exclusively in the luminal membrane of S2 and S3.
Temperature-Dependent Biological and Demographic Parameters of Coleomegilla maculata (Coleoptera: Coccinellidae) (2017)

Knowledge of the most suitable environmental conditions for an organism growth and development is a prerequisite for developing mass rearing technology. The temperature requirements for development and the optimal range of temperatures for growth and reproduction of Coleomegilla maculata De Geer were studied. The development time of individual C. maculata larvae was determined at 18, 21, 24, 27, 30, 33, and 36 °C. Development times were converted to development rates and fitted to a nonlinear temperature-dependent model and to the linear day-degree model. Life and fertility table analysis was used to determine the optimal temperature for population growth within a range of favorable temperatures including 24, 25, 26, 27, and 28 °C. Nonlinear estimates of thermal maximum (TM) for the postembryonic development of C. maculata was 35.09 ± 10.35 °C. Estimation of TM based on pupal development was much lower at 27.23 ± 1.52 °C. Linear and nonlinear estimates of low temperature development threshold were 13.13 ± and 4.77 ± 3.03 °C for the whole postembryonic development and 10.95 and 9.18 ± 1.36 °C for the pupal stage alone, respectively. The most favorable temperature for population growth was 25 °C, where C. maculata showed significantly higher intrinsic rate of increase (rm = 0.066) and significantly lower doubling time (10.57 d) than the other favorable temperatures tested. A negative value of rm was obtained at 28 °C, indicating population decline occurring at this temperature making it unfavorable for C. maculata.
A comparison of the collaborative information retrieval behaviour of two design teams (2003)

Abstract The goal of the collaborative information retrieval (CIR) project is to study situations where members of a work team are seeking, searching and using information collaboratively. A field study of two design teams (one at Microsoft and the other at the Boeing Company), guided by cognitive work analysis, has provided preliminary results. These show that: (a) the concept of CIR is elusive and does not easily lend itself to an operational definition; (b) work context has a strong effect on CIR behaviour; and (c) not all activities relating to CIR are carried out collaboratively. Acknowledgments This paper is based upon work supported by the National Science Foundation under grant no. 9908138.
H-Tree Clock Synthesis in RSFQ Circuits (2020)

Rapid single flux quantum (RSFQ) technology promises high performance, energy efficient supercomputers to achieve DoE exascale computing. An important challenge in VLSI complexity RSFQ circuits is ultra-high speed clocking and synchronization. A methodology to support the automated design of clock distribution networks for SFQ circuits is the focus of this paper. Global clock synthesis of SFQ circuits is applied to produce a near zero skew clock network. An algorithm is presented that produces an SFQ H-tree network with asymmetric leaves to propagate the clock signal to all SFQ gates. A Python-based system with location information for the interconnects, splitters, and leaves is described. The algorithm determines the physical locations and connections within the SFQ clock network and is applicable to automated routing and clock tree synthesis.
Bearings and Bearing Design for Transmissions (2014)

Abstract Modern transmission manufacturing uses made‐to‐measure rolling bearings that are subject to continuous improvement in terms of service life, friction, acoustics, and cost. In order to achieve optimum performance, the entire system of shafts and bearings must be considered in the selection of the bearing construction type and design. This chapter initially addresses the requirements that transmission bearings are subject to and the basic principles of the types of bearing construction most frequently used. Typical use cases will also be illustrated. Building on this basis, we will provide information on the procedure for bearing design. This is always transmission‐specific, which is why the focus is on system‐based calculation in particular. In practice, it is also important to know typical bearing damage that can occur if the design is not fit for purpose.
Ligand-independent dimerization of oncogenic v-erbB products involves covalent interactions (1996)

Mutant v-erbB products of avian c-erbB1 have previously been used to correlate structural domains of the receptor encoded by this proto-oncogene with tissue-specific transformation potential. In these studies, deletion of the ligand-binding domain of the receptor has been shown to be required for transformation of erythroblasts, fibroblasts, and endothelial cells. It has, therefore, been postulated that deletion of this domain results in an allosteric change in the receptor analogous to the ligand-bound state of the epidermal growth factor receptor; i.e., it induces a receptor conformation that is constitutively active with respect to mitogenic signaling. While oncogenic v-erbB products have been shown to be expressed on the cell surface of both fibroblasts and erythroblasts, no comprehensive analysis of the oligomeric potential of these products has been conducted. Since the first event known to follow epidermal growth factor binding to its receptor is oligomerization, and receptor dimerization has been correlated with mitogenic signaling, we have carefully analyzed the ability of several v-erbB products to oligomerize in the three target cell types transformed by these oncogenes. In this report, we demonstrate the v-erbB products can efficiently homodimerize in all three target tissues, that this dimerization is ligand independent and occurs at the cell surface, and that there is no apparent correlation between v-erbB dimerization and transformation of avian fibroblasts. Furthermore, both oncogenic and nononcogenic v-erbB products can heterodimerize with the native c-erbB1 product in chicken embryo fibroblasts, suggesting that heterodimerization between v-erB and native c-erbB1 is not sufficient to result in c-erbB1-mediated sarcomagenesis.
Antiarrhythmic activity, electrocardiographic effects and pharmacokinetics of the encainide metabolites O-desmethyl encainide and 3-methoxy-O-desmethyl encainide in man. (1988)

Although encainide is an effective antiarrhythmic agent, plasma concentrations and pharmacologic effects are not well correlated. One explanation is the generation of active metabolites: while in most patients (extensive metabolizers; EMs) concentrations of the metabolites O-desmethyl encainide (ODE) and 3-methoxy-O-desmethyl encainide (3MODE) are higher than those of encainide, a small subset (poor metabolizers; PMs) lack the ability to extensively biotransform encainide. Considerable data from studies in vitro and animal studies, as well as indirect evidence in patients, indicate that ODE and 3MODE produce the effects seen during long-term encainide therapy in EMs. We now report the initial direct evaluation of the pharmacologic actions of these metabolites of encainide in man. Nine patients with ventricular arrhythmias, seven of the EM phenotype and two of the PM phenotype, were studied. Chronic high-frequency ventricular arrhythmias were suppressed by encainide therapy in seven of nine; monitoring arrhythmia frequency during withdrawal of encainide allowed definition of plasma concentrations of encainide and metabolites associated with arrhythmia suppression. Intravenous infusions of both ODE and 3MODE suppressed chronic ventricular arrhythmias, while infusions of placebo had no effect. ODE clearance was a function of metabolizer phenotype, with higher clearance (mean 914 ml/min; range 554 to 1,314) in EMs than in PMs (434, 298 ml/min); moreover, 3MODE was detected during ODE infusions in all seven EMs but in neither PM. 3MODE clearance was more uniform (mean 289 ml/min in EMs [range 180-410] vs 300 and 78 ml/min in the two PMs) and ODE was not detected in any subject during 3MODE infusion. Encainide itself was not detected after any infusion of ODE or 3MODE. During withdrawal of encainide therapy, ODE plasma concentration at the time of arrhythmia recurrence was 55 +/- 40 ng/ml (mean +/- SD), while ODE by infusion was effective at a concentration of 37 +/- 15 ng/ml. Similarly, plasma concentration of 3MODE at the time of arrhythmia recurrence after withdrawal of chronic encainide was 116 +/- 35 ng/ml and that during 3MODE infusion was 105 +/- 50 ng/ml. While both compounds prolonged QRS duration, ODE was the more potent, increasing QRS by 9.2 +/- 1.6% per 100 ng/ml vs 1.2 +/- 0.5% per 100 ng/ml for 3MODE. On the other hand, 3MODE prolonged the corrected JT interval by 1.9 +/- 0.6% per 100 ng/ml, while ODE shortened it by 2.7 +/- 1.9% per 100 ng/ml.(ABSTRACT TRUNCATED AT 400 WORDS)
Nuclear Translocation Kinetics of NF-kappaB in Macrophages Challenged with Pathogens in a Microfluidic Platform. (2016)

Abstract not provided.
Density and Surface Tension of M2O-TeO2(M=Li, Na and K) Melts (2010)

The density and the surface tension of the binary tellurite melts, (M2O-TeO2 M=Li, Na and K) were measured. We investigated the thermal and compositional dependences of the properties. It was found that the density and the surface tension of the binary tellurite melts decreased with increasing temperature and M2O content. The dependences of the density and the surface tension were attributed to the behavior of added cation and the structural change of melt. It was thought that the added cation intruded into the interspace of the complex tellurite anion, and molar volume decreased, when the radius of added cation was small. TeO4 trigonal bipyramid changes to TeO4 − trigonal bipyramid and TeO3 trigonal pyramid with increasing temperature and M2O content. We explained that the dependences of the density and the surface tension on the behavior of added cation and the structural change of melt.
Renewables and Feasibility Considerations (2017)

This presentation from the ASTSWMO-EPA RE-Power Workshop held March 21-22, 2017, covers the topics of Renewables and Feasibility Considerations; and Resources Available for RE-Powering.
[Identification of Staphylococcus aureus in homogenates of hypertrophic adenoid (a preliminary report)]. (2010)

Standard adenoid swabs were taken from 33 children subjected to adenotomy. The bacterial growth was determined in swabs samples and in homogenates of surgically removed lymphatic tissue. Homogenates were also used for isolation of bacterial DNA. A standard bacteriological examination revealed the presence of Staphylococcus aureus only in 11 children (33%). In stark contrast S. aureus was detected in 20 samples (60%) of homogenized tissue, including all 11 positive swabs specimens. Results of plating were confirmed by molecular test (PCR- polymerase chain reaction). Inconsistent results between swabs and homogenate plating may indicate intracellular localization of S. aureus the tissue of hypertrophic adenoids.
MIPv6 Authorization and Configuration based on EAP (2006)

This draft defines an architecture, and related protocols, for
performing dynamic Mobile IPv6 authorization and configuration relying
on a AAA infrastructure. The necessary interaction between the AAA
server of the home provider and the mobile node is realized using EAP,
exploiting the capability of some EAP methods to convey generic
information items together with authentication data. This approach has
the advantage that the access equipment acts as a simple pass-through
for EAP messages and therefore does not play any active role in the
Mobile IPv6 negotiation procedure, which makes the solution easier to
deploy and maintain.
National Party Platforms, 1840–1956. Compiled by Kirk H. Porter and Donald Bruce Johnson. (Urbana: The University of Illinois Press. 1956. Pp. xi, 573. $10.00.) (1957)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
X-Ray crystal and molecular structure of a new diterpenoid of the ent-atisane class (1975)

I. Carrascal, B. Rodríguez, S. Valverde and J. Fayos, J. Chem. Soc., Chem. Commun., 1975, 815 DOI: 10.1039/C39750000815