gebhart/patrepeval huggingface dataset:
Correction to Optically Abrupt Localized Surface Plasmon Resonances in Si Nanowires by Mitigation of Carrier Density Gradients (2015)

ADVERTISEMENT RETURN TO ISSUEPREVAdditions and Correc...Additions and CorrectionsORIGINAL ARTICLEThis notice is a correctionCorrection to Optically Abrupt Localized Surface Plasmon Resonances in Si Nanowires by Mitigation of Carrier Density GradientsLi-Wei Chou, Dmitriy S. Boyuk, and Michael A. Filler*Cite this: ACS Nano 2015, 9, 5, 5625Publication Date (Web):May 14, 2015Publication History Received11 May 2015Published online14 May 2015Published inissue 26 May 2015https://pubs.acs.org/doi/10.1021/acsnano.5b02854https://doi.org/10.1021/acsnano.5b02854correctionACS PublicationsCopyright © 2015 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views391Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (42 KB) Get e-AlertscloseSUBJECTS:Nanowires,Surface plasmons Get e-Alerts
Oil Heavy Residues Oxy-combustion with CO2 Capture (2017)

Saudi Aramco and General Electric have been jointly developing oxy-combustion technology with CO2 capture for difficult to burn liquid fuels. The technology enables direct combustion of such fuels while addressing CO2 emissions concerns in a cost effective way. A 15 MW thermal testing campaign was performed in Windsor, CT firing heavy asphalt in air and oxy mode. The testing campaign results show a significant improvement in fuel combustibility in oxy mode compared to air firing in addition to 50% reduction in NOx emissions. The test results were used to validate a CFD model enabling simulation of various configuration for scale-up studies. The test results were considered in the basis of design for a 2800 MW OHR oxy-fired power plant with CO2 capture. The technology is ready for demonstration at a larger scale in a refining environment where it can synergistically be integrated with the refinery optimizing its operation and performance.
Exosomal microRNAs as Potentially Useful Tools in Cancer Biomarker Discovery (2012)

The development of minimally invasive tests for the detection and monitoring of cancers could greatly reduce the worldwide health burden of cancer. Recent discovery of a new class of small (22mer) non-coding RNA (miRNAs) opened up new perspectives in biomarker research. Since miRNA are directly involved in the regulation of almost all key cellular processes, including development, differentiation, proliferation, cell death and metabolism, they may prove to be powerful cancer biomarkers. Unlike other types of biomarkers, miRNAs in the circulation are protected within lipoprotein vesicles and thus are remarkably stable, making them robust and reliable biomarkers of cancer. In this review, we provide an overview on circulating miRNAs and their great potential as highly specific and sensitive biomarkers for tumor classification and prognostication. We discuss exosomal origin of the circulating miRNAs and additionally, address some recent findings in the new and upcoming area of exosomal miRNAs from cell culture supernatant and their potential in biomarkers discovery. We also review a selected number of recent patents relevant to the area of exosomal miRNAs relevant to biomarker discovery.
Multi-graph Convolutional Network for Unsupervised 3D Shape Retrieval (2020)

3D shape retrieval has attracted much research attention due to its wide applications in the fields of computer vision and multimedia. Various approaches have been proposed in recent years for learning 3D shape descriptor from different modalities. The existing works contain the following disadvantages: 1) the vast majority methods rely on the large scale of training data with clear category information; 2) many approaches focus on the fusion of multi-modal information but ignore the guidance of correlations among different modalities for shape representation learning; 3) many methods pay attention to the structural feature learning of 3D shape but ignore the guidance of structural similarity between every two shapes. To solve these problems, we propose a novel multi-graph network (MGN) for unsupervised 3D shape retrieval, which utilizes the correlations among modalities and structural similarity between two models to guide the shape representation learning process without category information. More specifically, we propose two novel loss functions: auto-correlation loss and cross-correlation loss. The auto-correlation loss utilizes information from different modalities to increase the discrimination of shape descriptor. The cross-correlation loss utilizes the structural similarity between two models to strengthen the intra-class similarity and increase the inter-class distinction. Finally, an effective similarity measurement is designed for the shape retrieval task. To validate the effectiveness of our proposed method, we conduct experiments on the ModelNet dataset. Experimental results demonstrate the effectiveness of our proposed method, and significant improvements have been achieved compared with state-of-the-art methods.
EOS²: Unstoppable Stateful PHP (demo) (2006)

This paper presents the architecture and implementation of the EOS2 \nfailure-masking framework for composite Web Services. EOS2 is based on the \nrecently proposed notion of interaction contracts (IC), and provides \nexactly-once execution semantics for general, arbitrarily distributed Web \nServices in the presence of message losses and component crashes without \nrequiring explicit coding effort by the application programmer. The EOS2 \nimplementation masks failures by adding a recovery layer to popular Web \ntechnology products: \n(i) the server-side script language PHP run on Apache Web server, and \n(ii) Internet browsers like IE to deliver recovery guarantees to the end-user.
Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases (2020)

Resveratrol, a polyphenol in red wine, has been reported as a calorie restriction mimetic with potential antiaging and antidiabetogenic properties. It is widely consumed as a nutritional supplement, but its mechanism of action remains a mystery. Here, we report that the metabolic effects of resveratrol result from competitive inhibition of cAMP-degrading phosphodiesterases, leading to elevated cAMP levels. The resulting activation of Epac1, a cAMP effector protein, increases intracellular Ca2+ levels and activates the CamKKβ-AMPK pathway via phospholipase C and the ryanodine receptor Ca2+-release channel. As a consequence, resveratrol increases NAD+ and the activity of Sirt1. Inhibiting PDE4 with rolipram reproduces all of the metabolic benefits of resveratrol, including prevention of diet-induced obesity and an increase in mitochondrial function, physical stamina, and glucose tolerance in mice. Therefore, administration of PDE4 inhibitors may also protect against and ameliorate the symptoms of metabolic diseases associated with aging.
New generation of high average power industry grade ultrafast ytterbium fiber lasers (2016)

We report an industrial grade picosecond and femtosecond pulse Yb fiber lasers with &gt;100 &mu;J pulse energy and hundreds of Watts of average power for improved laser machining speed of sapphire and glass. This highly efficient laser offers &gt;25% wall plug efficiency within a compact 3U rack-mountable configuration plus a long &gt;2m fiber delivery cable. Reconfigurable features such as controllable repetition rate, fine pulse duration control, burst mode operation and adjustable pulse energy permit the customer to tailor the laser to their application.
Self-organized metabotyping of obese individuals identifies clusters responding differently to bariatric surgery (2023)

Weight loss through bariatric surgery is efficient for treatment or prevention of obesity related diseases such as type 2 diabetes and cardiovascular disease. Long term weight loss response does, however, vary among patients undergoing surgery. Thus, it is difficult to identify predictive markers while most obese individuals have one or more comorbidities. To overcome such challenges, an in-depth multiple omics analyses including fasting peripheral plasma metabolome, fecal metagenome as well as liver, jejunum, and adipose tissue transcriptome were performed for 106 individuals undergoing bariatric surgery. Machine leaning was applied to explore the metabolic differences in individuals and evaluate if metabolism-based patients' stratification is related to their weight loss responses to bariatric surgery. Using Self-Organizing Maps (SOMs) to analyze the plasma metabolome, we identified five distinct metabotypes, which were differentially enriched for KEGG pathways related to immune functions, fatty acid metabolism, protein-signaling, and obesity pathogenesis. The gut metagenome of the most heavily medicated metabotypes, treated simultaneously for multiple cardiometabolic comorbidities, was significantly enriched in Prevotella and Lactobacillus species. This unbiased stratification into SOM-defined metabotypes identified signatures for each metabolic phenotype and we found that the different metabotypes respond differently to bariatric surgery in terms of weight loss after 12 months. An integrative framework that utilizes SOMs and omics integration was developed for stratifying a heterogeneous bariatric surgery cohort. The multiple omics datasets described in this study reveal that the metabotypes are characterized by a concrete metabolic status and different responses in weight loss and adipose tissue reduction over time. Our study thus opens a path to enable patient stratification and hereby allow for improved clinical treatments.
Influence of differences in current GOSATXCO2retrievals on surface flux estimation (2014)

We investigated differences in the five currently-available datasets of column-integrated CO2 concentrations () retrieved from spectral soundings collected by Greenhouse gases Observing SATellite (GOSAT) and assessed their impact on regional CO2 flux estimates. We did so by estimating the fluxes from each of the five datasets combined with surface-based CO2 data, using a single inversion system. The five datasets are available in raw and bias-corrected versions, and we found that the bias corrections diminish the range of the five coincident values by ~30% on average. The departures of the five individual inversion results (annual-mean regional fluxes based on -surface combined data) from the surface-data-only results were close to one another in some terrestrial regions where spatial coverage by each dataset was similar. The mean of the five annual global land uptakes was 1.7 ± 0.3 GtC yr−1, and they were all smaller than the value estimated from the surface-based data alone.
Regulation of Transplant Arteriosclerosis by CD25+CD4+ T Cells Generated to Alloantigen In Vivo (2007)

Background. CD25+CD4+ regulatory T cells have been shown to suppress alloimmunity in various experimental settings. Here, we hypothesized that alloantigen-reactive regulatory T cells would reduce the severity of transplant arteriosclerosis. Methods. CD25+CD4+ T cells from CBA mice that were pretreated with C57BL/6 (B.6) blood (donor-specific transfusion, DST) and nondepleting anti-CD4 Ab (YTS 177) were cotransferred with naïve CBA CD25−CD4+“effector” T cells into CBA-rag−/− mice. These animals received aorta transplants from B.6 CD31−/− donors. CBA wild-type recipients of B.6 aorta grafts were pretreated with 177/DST directly. Some animals received 6×105 CD25+CD4+ T cells from pretreated mice to augment regulation on day −1. Grafts were harvested on day 30. Results. Luminal occlusion of the graft caused by neointima formation was 29.3±19.4% (n=5) after transfer of effector T cells only. Co-transfer of CD25+CD4+ regulators reduced occlusion significantly (2.4±3.3%, n=3; P=0.009). This effect was partially abrogated in the presence of a CTLA4 blocking Ab (11.1±4.7%, n=4; P=0.008). Pretreating immunocompetent CBA recipients of B.6 aortic allografts with 177/DST did not reduce transplant arteriosclerosis significantly (43.0±15.7%, n=5 vs. 56.6±16.8%, n=5; 177/DST vs. controls; P=0.22). However, when pretreated primary CBA recipients received an additional transfer of 6 × 105 CD25+CD4+ T cells procured from other mice pretreated with 177/DST before transplantation, luminal occlusion of the graft was markedly reduced (33.0±7.6%, n=5; P=0.002). Conclusion. Regulatory T cells generated in vivo to alloantigen can prevent CD25−CD4+ T-cell−mediated transplant arteriosclerosis. In immunocompetent recipients, these cells have potential to be used as cellular immunotherapy to control transplant arteriosclerosis.
Cytokine Intervention permits dose escalation of radioantibody. An analysis of myelostimulation by bolus versus continuous infusion of IL-1/GM-CSF (1994)

Although continuous infusion of cytokines proved to be a better method of reducing hematopoietic toxicity, further dose escalation of radioimmunotherapy using the "pump" method of cytokine delivery was not possible. Cytokine intervention by either mode of delivery permits a 25% dose intensification without the dose becoming lethal. Further escalation is not feasible, possibly because of other end organ toxicity.
Conformational preferences and self‐association modes of two diastereomeric statine derivatives (1987)

The conformational preferences and self-association modes of the two diastereomeric N-acetyl, methylamides of 3-hydroxy, 4-amino, 6-methylheptanoic acid (statine) with (R, S) and (S, S) configurations at the 3-hydroxy and 4-amino carbons, respectively, have been determined in solution as well as in the solid state by infrared absorption, 1H nuclear magnetic resonance, and X-ray diffraction. Conformational energy computations have also been performed in parallel. In the crystal state, the change in chirality of the hydroxyl group induces different intermolecular H-bonding schemes in the (R, S) isomer compared to the two structurally distinct molecules in the asymmetric unit of the (S, S) isomer. Different propensities to self-aggregate are seen in solvents of low polarity. In solvents of high polarity, however, the molecules of both isomers are largely solvated, while still keeping some local conformational restriction. Conformational energy computations indicate that in vacuo the two diastereomers exhibit different flexibility, and a preferred conformation with a different type of intramolecular H-bond.
Rapid and economic chiral‐HPLC method of nebivolol enantiomers resolution in dosage formulation (2011)

A fast, economic, reproducible, accurate, effective, rugged and selective chiral-HPLC method was developed and validated for the enantiomeric resolution of nebivolol enantiomers [(+)-RRRS and (-)-SSSR)] in dosage formulation. The method was rapid as chiral separation occurred within only 12 min. The mobile phase used was n-heptane-ethanol-DEA (85:15:0.1, v/v) at 3.0 mL/min flow-rate with 225 nm detection. The column used was an amylase-based 3-AmyCoat (150 × 46 mm) [tris-(3,5-dimethylphenyl carbamate)]. The capacity factors of (+)-RRRS and (-)-SSSR enantiomers were 7.85 and 10.90 while the separation and resolution factors were 1.39 and 1.83, respectively. The limits of detection and quantitation for (+)-RRRS enantiomer were 4.5 and 10.00 µg/mL, while these values for (-)-SSSR enantiomer were 4.1 and 8.2 µg/mL, respectively. The linearity was observed in the concentrations range of 0.10-1.0 mg/mL for both enantiomers. The π-π interactions, hydrogen bonds, dipole-dipole interactions and steric effects control the chiral resolution of nebivolol enantiomers on the reported chiral column. The reported method can be used for the quality control of nebivolol in pharmaceutical preparations with good economy. In addition, this method can also be used for the analysis of (+)-RRRS and (-)-SSSR) enantiomers in biological and environmental samples.
The Multiple Myeloma Research Consortium Genomics Initiative. (2007)

Abstract The Multiple Myeloma Research Consortium (MMRC) Genomics Initiative is a three-year program to analyze tumor tissue from hundreds of multiple myeloma (MM) patients via gene expression profiling (GEP), comparative genomic hybridization (aCGH), and exon re-sequencing. In addition, RNAi knockdown of selected genes in MM tumor cell lines is being evaluated to identify potential new targets. All genomic data generated is scheduled for placement in an open-access Multiple Myeloma Genomics Portal pre-publication and in near real-time (www.broad.mit.edu/mmgp). Additionally, samples are also destined for drug validation and correlative science on clinical protocols as this study moves forward. This comprehensive project is spearheaded by the MMRC and conducted via collaboration with the Eli and Edythe L. Broad Institute of MIT and Harvard, the Translational Genomics Research Institute (TGen), Mayo Clinic Arizona, and The Dana-Farber Cancer Center. The study is supported by the collection from member institutions of the MMRC of bone marrow aspirates and matched peripheral blood samples from over 1000 patients. Specific genomic technologies that are currently being employed across this sample set include GEP using Affymetrix Human Genome U133A 2.0 Plus Arrays, and, in parallel, efforts to identify regions of genomic gain and loss are using Agilent Human Genome CGH arrays. In contrast to other large-scale genomic projects based on exon-sequencing of targeted gene sets, this project will be the first to perform genome-scale single molecule sequencing (SMS) of DNA from patient specimens. Results will be targeted against candidate classes of genes (e.g. kinases, phosphatases, known oncogenes and tumor suppressors), and genes from GEP or within candidate regions of copy gain or loss identified by the aCGH experiments. Mutations will be further validated in an independent set of patient specimens. Finally we will attempt to identify points of vulnerability of MM through systematic loss-of-function screens in myeloma cell lines using high-throughput RNA interference (using both shRNA and siRNA platforms). Importantly, data generated from this genomics initiative will ultimately be made public pre-publication through the established MMRC Multiple Myeloma Genomics Portal. Data from all aspects of this project (sample collection and analyte isolation, GEP, aCGH, SMS, RNAi and bioinformatics) will be described in this presentation. The power of this study is the comprehensive collection of gene expression, CGH, and genome sequencing on a single reference set of clinically annotated samples. The addition of RNAi screens makes this a very important and unique data resource, which we hope will help expedite the discovery of novel targeted agents for MM scientific community.
A Perspective of TM-Nx (TM=Fe, Co, and x=2, 4) Non-PGM Electrocatalysts From First-Principles Calculations (2013)

Abstract not Available.
Mannose-sensitive and Gal-Gal binding Escherichia coli pili from recombinant strains. Chemical, functional, and serological properties. (1983)

Chromosomal genes encoding the MS and Gal-Gal binding properties have been cloned into separate recombinants and their respective pili characterized. Hapten inhibition of hemagglutination with synthetic carbohydrate receptor analogues and carbohydrate-adsorbed latex agglutination studies indicate that Gal-Gal and MS pili collectively exhibit the binding properties of the parent strain. MS pili migrated in SDS-PAGE with an Mr of 19 kdaltons and 17 kdaltons; the Mr of Gal-Gal pili was 17.5 kdaltons. The pili are chemically similar by amino acid composition and when the N-terminal cysteines are aligned, 8 of the 13 residues between positions 9 and 22 are homologous. Further, carboxy-terminal sequence homology was inferred from the carboxypeptidase digestion of a MS pili and the sequence of a carboxy-terminal tryptic peptide from Gal-Gal pili.
Supplementary Video S3 from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs (2023)

&lt;p&gt;Supplementary Video S3. Time-lapse images of hTERT-RPE1-Arl13b-GFP cells starved in serum-free Opti-MEM for 48 hours, then incubated for 3 hours in 1 µM alisertib + 20% FBS.&lt;/p&gt;
Fabrication of a vertically-stacked passive-matrix micro-LED array structure for a dual color display (2017)

We report a color tunable display consisting of two passive-matrix micro-LED array chips. The device has combined vertically stacked blue and green passive-matrix LED array chips sandwiched by a transparent bonding material. We demonstrate that vertically stacked blue and green micro-pixels are independently controllable with operation of four color modes. Moreover, the color of each pixel is tunable in the entire wavelength from the blue to green region (450 nm - 540 nm) by applying pulse-width-modulation bias voltage. This study is meaningful in that a dual color micro-LED array with a vertically stacked subpixel structure is realized.
Convergence Properties of Some Spike-Triggered Analysis Techniques (2002)

We analyze the convergence properties of three spike-triggered data analysis techniques. All of our results are obtained in the setting of a (possibly multidimensional) linear-nonlinear (LN) cascade model for stimulus-driven neural activity. We start by giving exact rate of convergence results for the common spike-triggered average (STA) technique. Next, we analyze a spike-triggered covariance method, variants of which have been recently exploited successfully by Bialek, Simoncelli, and colleagues. These first two methods suffer from extraneous conditions on their convergence; therefore, we introduce an estimator for the LN model parameters which is designed to be consistent under general conditions. We provide an algorithm for the computation of this estimator and derive its rate of convergence. We close with a brief discussion of the efficiency of these estimators and an application to data recorded from the primary motor cortex of awake, behaving primates. 1
Transmission and Switching Technologies for 5G Transport Networks (2018)

5G is requiring higher capacity and performance to the optical transport network while demanding lower cost and energy consumption. This work illustrates new technologies such as novel modulation formats and Photonic Integrated Circuits (PICs) for cost effective transmission and switching of high speed (50 Gbit/s and beyond) signals in 5G fronthaul and backhaul networks.
Increased Left Ventricular Torsion in Uncomplicated Type 1 Diabetic Patients (2009)

We demonstrate that LV torsion is increased in young patients with uncomplicated type 1 diabetes and that coronary microvascular disease may play a key pathophysiological role in the development of increased LV torsion.