gebhart/patrepeval huggingface dataset:
The Influence of Learning on Evolution: A Mathematical Framework (2009)

The Baldwin effect can be observed if phenotypic learning influences the evolutionary fitness of individuals, which can in turn accelerate or decelerate evolutionary change. Evidence for both learning-induced acceleration and deceleration can be found in the literature. Although the results for both outcomes were supported by specific mathematical or simulation models, no general predictions have been achieved so far. Here we propose a general framework to predict whether evolution benefits from learning or not. It is formulated in terms of the gain function, which quantifies the proportional change of fitness due to learning depending on the genotype value. With an inductive proof we show that a positive gain-function derivative implies that learning accelerates evolution, and a negative one implies deceleration under the condition that the population is distributed on a monotonic part of the fitness landscape. We show that the gain-function framework explains the results of several specific simulation models. We also use the gain-function framework to shed some light on the results of a recent biological experiment with fruit flies.
The normal glenohumeral relationships. An anatomical study of one hundred and forty shoulders. (1992)

We measured the dimensions of the humeral and glenoid articular surfaces in 140 shoulders that were representative of a given population of patients, and also evaluated several glenohumeral relationships. Ninety-six measurements were made in the shoulders of cadavera and forty-four, on magnetic resonance-imaging studies of living patients. Eighty-five per cent of the humeral measurements fell within eight fixed combinations of the radius of curvature and the thickness of the humeral head, in two-millimeter increments. The average radius of curvature of the humeral head in the coronal plane was 24 +/- 2.1 millimeters (range, nineteen to twenty-eight millimeters). The average thickness of the humeral head was 19 +/- 2.4 millimeters (range, fifteen to twenty-four millimeters). There was a wide variability in the size of the humeral head and a direct correlation between the differences in size and the heights in both men and women. The humeral articular surface was spherical in the center; however, the peripheral radius was two millimeters less in the axial plane than in the coronal plane. Thus, the peripheral contour of the articular surface was elliptical (ratio, 0.92). The radius of curvature of the glenoid, measured in the coronal plane, was an average of 2.3 +/- 0.2 millimeters greater than that of the humeral head. The average dimensions of the glenoid in the superior-inferior and anterior-posterior (lower half) directions were 39 +/- 3.5 millimeters (range, thirty to forty-eight millimeters) and 29 +/- 3.2 millimeters (range, twenty-one to thirty-five millimeters). The anterior-posterior dimension of the glenoid was pear-shaped, the lower half being larger than the top half. The ratio of the lower half to the top half was 1:0.80 +/- 0.01. There was a strong linear correlation between the lateral humeral offset and the size of the humeral head (radius of curvature and thickness). The average lateral humeral offset was 56 +/- 5.7 millimeters (range, forty-three to sixty-seven millimeters). The superior most point on the humeral articular surface was an average of 8 +/- 3.2 millimeters (range, three to twenty millimeters) cephalad to the top of the greater tuberosity. Our data show that reconstruction of the lateral humeral offset is important in optimization of the moment arm of the deltoid and rotator cuff and of the normal tension of the soft tissue after prosthetic reconstruction.
Stimulation of renal phospholipid formation during potassium depletion. (1977)

Potassium depletion induces increased membrane phospholipid formation and renal growth in rats. To determine the mechanism by which potassium depletion augments phospholipid formation, the metabolism of radioactive choline, a precursor of choline-containing phospholipids, was studied in renal slices. Cortical and medullary tissue from potassium-depleted and control animals accumulated extracellular choline and sequentially converted it to phosphorylcholine, cytidine diphosphocholine (CDP-choline), and choline phosphoglyceride, thereby demonstrating that renal cells can utilize the Kennedy pathway for phospholipid synthesis. [14C]Choline uptake into intracellular fluid was increased in cortical slices from potassium-depleted animals. The apparent Km and Vmax of the kinase reaction which converts entering [14C]choline to [14C]phosphorylcholine were unchanged during potassium depletion. The rate of [14C]phosphorylcholine conversion to [14C]CDP-choline was also unchanged. In contrast, the Vmax of [14C]choline phosphoglyceride formation from [14C]CDP-choline was increased, whereas the apparent Km for this reaction was unchanged. These results indicate that increased renal choline phosphoglyceride formation during potassium depletion can occur via the Kennedy pathway and appears to be mediated by increases in choline uptake and the rate of CDP-choline incorporation into phospholipid, the first and last steps of the pathway.
A Miniaturized Linear pH Sensor Based on a Highly Photoluminescent Self‐Assembled Europium(III) Metal–Organic Framework (2009)

Ein Miniatur-pH-Sensor für den Bereich pH 5–7.5 enthält ein photolumineszierendes Metall-organisches Gerüst mit zwei unterschiedlichen Eu3+-Zentren (Eu1 und Eu2; siehe Bild), das durch Wasserstoffbrücken und π-π-Wechselwirkungen zusammengehalten wird. Das Material hat die Vorteile einer sehr hohen Quantenausbeute und eines ausgewogenen Wechselspiels zwischen Absorption, Energietransfer und Emission. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation (2023)

Somatic activating mutations of <i>PIK3CA</i> are associated with development of vascular malformations (VMs). Here, we describe a microfluidic model of <i>PIK3CA</i>-driven VMs consisting of human umbilical vein endothelial cells expressing <i>PIK3CA</i> activating mutations embedded in three-dimensional hydrogels. We observed enlarged, irregular vessel phenotypes and the formation of cyst-like structures consistent with clinical signatures and not previously observed in cell culture models. Pathologic morphologies occurred concomitant with up-regulation of Rac1/p21-activated kinase (PAK), mitogen-activated protein kinase cascades (MEK/ERK), and mammalian target of rapamycin (mTORC1/2) signaling networks. We observed differential effects between alpelisib, a PIK3CA inhibitor, and rapamycin, an mTORC1 inhibitor, in mitigating matrix degradation and network topology. While both were effective in preventing vessel enlargement, rapamycin failed to reduce MEK/ERK and mTORC2 activity and resulted in hyperbranching, while inhibiting PAK, MEK1/2, and mTORC1/2 mitigates abnormal growth and vascular dilation. Collectively, these findings demonstrate an in vitro platform for VMs and establish a role of dysregulated Rac1/PAK and mTORC1/2 signaling in <i>PIK3CA</i>-driven VMs.
Chiral Amphiphilic Self-Assembled α,α‘-Linked Quinque-, Sexi-, and Septithiophenes:  Synthesis, Stability and Odd−Even Effects (2006)

The synthesis, characterization, and self-assembly in butanol of a series of well-defined alpha,alpha'-linked quinqui-, sexi-, and septithiophenes substituted, via ester links at their termini, by chiral oligo(ethylene oxide) chains carrying an alpha, beta, delta, and epsilon methyl, respectively, are reported. Studies of the self-assembly of these molecules using UV/visible absorption, luminescence, and circular dichroism spectroscopies reveal, for the sexithiophene case, that the magnitude of the observed Cotton effect in the aggregates diminishes progressively as the chiral substituent is moved away from the thiophene segment. The stability of the assemblies increases with the length of the oligothiophene and as the substituent chiral unit is moved away from the aromatic core, being greatest for the unsubstituted case. The sign of the Cotton effect alternates in an "odd/even" manner as the position of the chiral substituent is moved along the oligo(ethylene oxide) chain and on going from the quinquethiophene to the septithiophene having the same side chain. Atomic force microscopy on materials deposited from solution on an aluminum or glass surface and optical measurements show that capsules are formed from the oligothiophenes with H-type packing of the aromatic segments.
Extraarticular Hand Fractures in Adults (2006)

Level V (expert opinion).
Fibulin-5 binds urokinase-type plasminogen activator and mediates urokinase-stimulated β1-integrin-dependent cell migration (2012)

uPA (urokinase-type plasminogen activator) stimulates cell migration through multiple pathways, including formation of plasmin and extracellular metalloproteinases, and binding to the uPAR (uPA receptor; also known as CD87), integrins and LRP1 (low-density lipoprotein receptor-related protein 1) which activate intracellular signalling pathways. In the present paper we report that uPA-mediated cell migration requires an interaction with fibulin-5. uPA stimulates migration of wild-type MEFs (mouse embryonic fibroblasts) (Fbln5+/+ MEFs), but has no effect on fibulin-5-deficient (Fbln5-/-) MEFs. Migration of MEFs in response to uPA requires an interaction of fibulin-5 with integrins, as MEFs expressing a mutant fibulin-5 incapable of binding integrins (Fbln(RGE/RGE) MEFs) do not migrate in response to uPA. Moreover, a blocking anti-(human β1-integrin) antibody inhibited the migration of PASMCs (pulmonary arterial smooth muscle cells) in response to uPA. Binding of uPA to fibulin-5 generates plasmin, which excises the integrin-binding N-terminal cbEGF (Ca2+-binding epidermal growth factor)-like domain, leading to loss of β1-integrin binding. We suggest that uPA promotes cell migration by binding to fibulin-5, initiating its cleavage by plasmin, which leads to its dissociation from β1-integrin and thereby unblocks the capacity of integrin to facilitate cell motility.
Acoustics 1988: Extracorporeal shock wave lithotripsy (1989)

First Page
Role of the Asialoglycoprotein Receptor in Binding and Entry of Hepatitis C Virus Structural Proteins in Cultured Human Hepatocytes (2002)

We used a baculovirus-based system to prepare structural proteins of hepatitis C virus (HCV) genotype 1a. Binding of this preparation to cultured human hepatic cells was both dose dependent and saturable. This binding was decreased by calcium depletion and was partially prevented by ligands of the asialoglycoprotein receptor (ASGP-R), thyroglobulin, asialothyroglobulin, and antibody against a peptide in the carbohydrate recognition domain of ASGP-R but not preimmune antibody. Uptake by hepatocytes was observed with both radiolabeled and dye-labeled HCV structural proteins. With hepatocytes expressing the hH1 subunit of the ASGP-R fused to green fluorescent protein, we could show by confocal microscopy that dye stain cointernalized with the fusion protein in an area surrounding the nucleus. Internalization was more efficient with a preparation containing p7 than with one that did not. The two preparations bound to transfected 3T3-L1 cells expressing either both (hH1 and hH2) subunits of the ASGP-R (3T3-22Z cells) or both hH1 and a functionally defective variant of hH2 (3T3-24X cells) but not to parental cells. Additionally, uptake of dye-labeled preparation containing p7 was observed with 3T3-22Z cells but not with 3T3-L1 or 3T3-24X cells or with the preparation lacking p7, suggesting that p7 regulates the internalization properties of HCV structural proteins. Our observations suggest that HCV structural proteins bind to and cointernalize with the ASGP-R in cultured human hepatocytes.
Radio Network Dimensioning (2009)

This chapter contains sections titled: Radio Network Planning Process Capacity Link Budget Coverage Area Calculations Trade-offs Between the Parameters Radio Network Measurements and Analysis EMC and Bio-effect Calculations
Pre-processing based soft-demapper for per-tone MIMO operation in QAM-FBMC systems (2015)

As a promising candidate to replace cyclic prefixed orthogonal frequency division multiplexing (CP-OFDM), a new quadrature amplitude modulation filter-bank multi-carrier (QAM-FBMC) has been proposed for enabling spectral efficiency increase and spectrum confinement while keeping near orthogonality. QAM transmission can combat intrinsic interference of conventional offset-QAM (OQAM)-FBMC, which is main bottleneck in channel estimator and multiple antenna transceiver design. Compared to existing single filter based QAM-FBMC, the new QAM-FBMC has more optimization freedom in multiple prototype filters to increase self signal-to-interference ratio (SIR). In this paper, the possibility of per-tone multiple input multiple output (MIMO) reception in the new QAM-FBMC system is exploited. Our MIMO receiver is constructed with per-tone MIMO equalization in oversampled signal domain and its soft-demapper in symbol domain. Not only the separate log likelihood ratio (LLR) calculation per stream but also joint LLR calculation (i.e., soft maximum likelihood (ML) detection) is implemented with pre-processing. Simulation results show that the per-tone MIMO reception in QAM-FBMC is comparable to that of CP-OFDM.
Fatigue Crack Fracture and Arrest in Fiber Reinforced Concrete under Interfacial Bond Degradation (1998)

Peer Reviewed
A new differential pressure flow meter for measurement of human breath flow: Simulation and experimental investigation (2015)

The development and performance characterization of a new differential pressure-based flow meter for human breath measurements is presented in this article. The device, called a "Confined Pitot Tube," is comprised of a pipe with an elliptically shaped expansion cavity located in the pipe center, and an elliptical disk inside the expansion cavity. The elliptical disk, named Pitot Tube, is exchangeable, and has different diameters, which are smaller than the diameter of the elliptical cavity. The gap between the disk and the cavity allows the flow of human breath to pass through. The disk causes an obstruction in the flow inside the pipe, but the elliptical cavity provides an expansion for the flow to circulate around the disk, decreasing the overall flow resistance. We characterize the new sensor flow experimentally and theoretically, using Comsol Multiphysics<sup>®</sup> software with laminar and turbulent models. We also validate the sensor, using inhalation and exhalation tests and a reference method.
Brushless DC motor control using bit-streams (2008)

The control of a brushless dc (BLDC) motor, using bit-streams is presented. Bi-polar signals are represented using a uniformly weighted bit-stream which can be manipulated using simple digital logic to create a variety of control actions. This paper presents the functional elements required for the implementation of a proportional integral (PI) controller to affect speed and torque control on a BLDC motor. Preliminary experimental results on a standard BLDC motor using an Altera field programmable gate array (FPGA) are presented and show the viability of this technique.
Regenerative Medicine Strategies for Treating Neurogenic Bladder (2011)

Neurogenic bladder is a general term encompassing various neurologic dysfunctions of the bladder and the external urethral sphincter. These can be caused by damage or disease. Therapeutic management options can be conservative, minimally invasive, or surgical. The current standard for surgical management is bladder augmentation using intestinal segments. However, because intestinal tissue possesses different functional characteristics than bladder tissue, numerous complications can ensue, including excess mucus production, urinary stone formation, and malignancy. As a result, investigators have sought after alternative solutions. Tissue engineering is a scientific field that uses combinations of cells and biomaterials to encourage regeneration of new, healthy tissue and offers an alternative approach for the replacement of lost or deficient organs, including the bladder. Promising results using tissue-engineered bladder have already been obtained in children with neurogenic bladder caused by myelomeningocele. Human clinical trials, governed by the Food and Drug Administration, are ongoing in the United States in both children and adults to further evaluate the safety and efficacy of this technology. This review will introduce the principles of tissue engineering and discuss how it can be used to treat refractory cases of neurogenic bladder.
Experimental realization of non resonant photon neutralizer for negative ion beams. Concept of neutralizer for big NBI systems (2018)

Concept of photon neutralizer for large ITER like NBI system has been proposed. The use of proposed concept allows beam neutralization with significantly lower requirements concerning optical radiation quality in comparison with resonance schemes, also there is no need for complicated stabilization and tuning system.
Surface Chemistry and Nanoscale Wet Etching of Group IV Semiconductors in Acidic H<sub>2</sub>O<sub>2</sub> Solutions (2021)

In this atomic-scale study on technologically relevant group IV semiconductors, Ge and SiGe, we relate surface chemistry, in particular the nature of surface oxides, to wet etching kinetics. ICP-MS quantification of Ge in HCl solution containing H 2 O ­2 as the oxidizing agent showed that the Si bulk concentration strongly impacted the etching kinetics. Post operando synchrotron XPS provided insight into the surface oxide chemistry involved in the etching process: a non-homogeneous porous layer with a depletion of Ge components at the outer surface due to pull out effects.
Polymeric Protection of Navy Fighter Jet Towlines (2007)

Abstract : Towed decoys are used to protect military fighter and transport aircraft against radar-guided air-to-air and surface-to-air missiles. A towed decoy provides an aircraft-like target that draws an oncoming missile away from the aircraft that is being protected. The towline in general consists of a set of conducting and communication members, which is ensheathed by a structurally protective envelope (strength member) made of a high-performance organic fiber. A towline can burn when exposed to a fighter jet's afterburner plume, resulting in the loss of the decoy. This burn is a result of the initial thermo-oxidative degradation of the protective sheath and the subsequent breakdown of the conducting and communication members. The Naval Research Laboratory is part of an undertaking of the U.S. Navy Integrated Defensive Electronic Countermeasures (IDECM) and Radio Frequency Countermeasures (RFC) programs, who share a central objective, which is the development of advanced towline systems that can function at high temperatures and for longer durations. Siloxane polymers that contain carborane clusters, developed simultaneously by Olin Laboratories and Union Carbide in the 1960s, have exceptional thermal stability in air. Research at NRL has furthered the chemistry of these thermo-oxidatively stable polymers by incorporating crosslinkable diacetylene units. The improved polymers, collectively known as poly(carborane-siloxane-acetylene)s or PCSAs, produce extended network structures through the thermally initiated crosslinking reactions of the diacetylene groups. These highly processable PCSAs are ideally suited to protect high-performance organic fiber strength members (e.g., Kevlar, Zylon, carbon fibers) used in Navy fighter jet towlines against thermo-oxidative degradation.
Engineered Axonal Tracts as “Living Electrodes” for Synaptic‐Based Modulation of Neural Circuitry (2017)

Brain-computer interface and neuromodulation strategies relying on penetrating non-organic electrodes/optrodes are limited by an inflammatory foreign body response that ultimately diminishes performance. A novel "biohybrid" strategy is advanced, whereby living neurons, biomaterials, and microelectrode/optical technology are used together to provide a biologically-based vehicle to probe and modulate nervous-system activity. Microtissue engineering techniques are employed to create axon-based "living electrodes", which are columnar microstructures comprised of neuronal population(s) projecting long axonal tracts within the lumen of a hydrogel designed to chaperone delivery into the brain. Upon microinjection, the axonal segment penetrates to prescribed depth for synaptic integration with local host neurons, with the perikaryal segment remaining externalized below conforming electrical-optical arrays. In this paradigm, only the biological component ultimately remains in the brain, potentially attenuating a chronic foreign-body response. Axon-based living electrodes are constructed using multiple neuronal subtypes, each with differential capacity to stimulate, inhibit, and/or modulate neural circuitry based on specificity uniquely afforded by synaptic integration, yet ultimately computer controlled by optical/electrical components on the brain surface. Current efforts are assessing the efficacy of this biohybrid interface for targeted, synaptic-based neuromodulation, and the specificity, spatial density and long-term fidelity versus conventional microelectronic or optical substrates alone.
40.1: A 2.6‐in. Poly‐Si TFT‐LCD HDTV Display with Monolithic Integrated 8‐bit Digital Data Drivers (1998)

Abstract A 2.6‐inch TFT‐LCD with 1920 × 1080 pixels which conforms to full advanced TV (ATV) format has been developed. An 8‐bit digital data driver with digital‐to‐analog converters (DACs), which can realize 256 level gray scale, has been integrated in monolithic driver. In addition, the circuit using the high mobility and low threshold voltage TFTs can operate directly on 80 MHz digital video data with 5 V supply voltage.
A health-care data model based on the HL7 Reference Information Model (2007)

The integration of medical information from various sources is gaining in importance as hospitals and medical research centers attempt to gain new insights into existing data. The Health Level Seven® (HL7®) organization has developed an abstract information model for health-care data, the HL7 Reference Information Model (RIM). We describe in this paper our approach to implementing a physical data model based on RIM. Our approach, which combines elements of entity-relationship data modeling and entity-attribute-value data modeling, involves the modeling of base RIM classes, RIM inheritance, and RIM data types. We incorporated the resulting data model into IBM Clinical Genomics, a product that integrates clinical and genomic data in a way that enables medical researchers to carry out clinical research.