gebhart/patrepeval huggingface dataset:
T cell Co-Stimulatory molecules ICOS and CD28 stratify idiopathic pulmonary fibrosis survival (2019)

Idiopathic pulmonary fibrosis (IPF) is a devastating disease that kills as many Americans as breast cancer each year. This study investigated whether lung function decline and survival associates with adaptive immunity in patients with IPF, specifically the expression of checkpoint molecules ICOS, CD28 and PD-1 on circulating CD4 T cells. Clinical data, blood samples and pulmonary function tests were collected prospectively and longitudinally from 59 patients with IPF over a study period of 5 years. Patients were followed until death, lung transplantation, or study end, and cell surface expression of CD45RO, CD28, ICOS, and PD-1 was measured on CD4 T cells via flow cytometry. Repeated measures of ICOS and CD28 on CD4 T cells revealed significant associations between declining ICOS and CD28 expression, and declining lung function parameters FVC and DLCO, independent of age, sex, race, smoking history, or immunosuppressant use. Strikingly, patients in the highest quintile of ICOS at study entry had markedly improved survival, while those with low CD28 fared poorly. No change in PD-1 expression was found. Analysis of ICOS and CD28 from the first blood draw identified three populations of IPF patients; those at high risk for early death, those with intermediate risk, and those at low risk. These results highlight the role of T cell mediated immunity in IPF survival, finding the assessment of two T cell stimulatory checkpoint molecules, CD28 and ICOS, was sufficient to discriminate three distinct survival trajectories over 5 years of patient follow up.
Strength evolution after high temperature exposure of coated carbon fiber rovings used for a fiber-reinforced cementitious matrix (FRCM) (2013)

This paper presents experimental results of the tensile strength decrease of coated Carbon Fiber rovings after high temperature exposure up to 1000°C. The composite material is used as a mesh reinforcement for various shotcrete applications (FRCM - Fiber Reinforced Cementitious Mortar) in structural retrofitting projects. In case of a fire accident, it is mandatory to dispose of a certain residual strength after high temperature exposure in order to guarantee structural safety. The current investigation treats unidirectional tensile strength tests on Carbon Fiber rovings carried out at Empa. The investigation was performed at room temperature on Carbon Fiber rovings after having been thermally subjected to constant temperature of 300, 500, 700 and 1000°C in a tube furnace for 30 minutes. It can be observed that an exposure at 300°C for half an hour does not affect the mechanical properties of the analyzed reinforcement. However, a further increase in temperature starts seriously damaging the material's ability at 500°C, whilst no residual strength is left at 700 and 1000°C, respectively. Additionally, reinforced concrete plate strips were strengthened with a fiber-reinforced-cementitious-matrix (FRCM) layer and subsequently subjected to fire at the 'Versuchsstollen Hagerbach' (CH), temperature was controlled according to the European ETK-temperature curve. The measured temperature evolution on the Carbon Fiber rovings (under a total concrete/shotcrete cover of 40 mm for the steel reinforcement) together with the previously performed tensile tests lead to the conclusion that the inner steel reinforcement, for which temperature was also monitored, is partially protected by the FRCM layer and does not trespass 250°C in this case.
Targeting the IspD Enzyme in the MEP Pathway: Identification of a Novel Fragment Class (2021)

The enzymes of the 2-C-methylerythritol-d-erythritol 4-phosphate (MEP) pathway (MEP pathway or non-mevalonate pathway) are responsible for the synthesis of universal precursors of the large and structurally diverse family of isoprenoids. This pathway is absent in humans, but present in many pathogenic organisms and plants, making it an attractive source of drug targets. Here, we present a high-throughput screening approach that led to the discovery of a novel fragment hit active against the third enzyme of the MEP pathway, PfIspD. A systematic SAR investigation afforded a novel chemical structure with a balanced activity-stability profile (16). Using a homology model of PfIspD, we proposed a putative binding mode for our newly identified inhibitors that sets the stage for structure-guided optimization.
Statement of Ownership, Management and Circulation (1993)

For Sale: 3 ADC Propatch W i n .RTS Audio Patch Panels at $350 each or 3 for $1000.2Daniels Pneumatic Coax Crimpers, use standard AMP, King and Daniels
Comparison of features for musical instrument recognition (2002)

Several features were compared with regard to recognition performance in a musical instrument recognition system. Both mel-frequency and linear prediction cepstral and delta cepstral coefficients were calculated. Linear prediction analysis was carried out both on a uniform and a warped frequency scale, and reflection coefficients were also used as features. The performance of earlier described features relating to the temporal development, modulation properties, brightness, and spectral synchronity of sounds was also analysed. The data base consisted of 5286 acoustic and synthetic solo tones from 29 different Western orchestral instruments, out of which 16 instruments were included in the test set. The best performance for solo tone recognition, 35% for individual instruments and 77% for families, was obtained with a feature set consisting of two sets of mel-frequency cepstral coefficients and a subset of the other analysed features. The confusions made by the system were analysed and compared to results reported in a human perception experiment.
Raman induced cross talk with PRBS modulation (2004)

Stimulated Raman scattering between correlated PRBS modulated channels in experimental WDM systems causes cross-talk penalties. Various de-correlation techniques do not suppress this effect. We report on experimental observation of penalties up to 3 dB and find an optimum de-correlation technique.
Effects of Different Auditory Feedback Frequencies in Virtual Reality 3D Pointing Tasks (2021)

Auditory error feedback is commonly used in 3D Virtual Reality (VR) pointing experiments to increase participants' awareness of their misses. However, few papers describe the parameters of the auditory feedback, such as the frequency. In this study, we asked 15 participants to perform an ISO 9241-411 pointing task in a distributed remote experiment. In our study, we used three forms of auditory feedback, i.e., C4 (262 Hz), C8 (4186 Hz) and none. According to the results, we observed a speed-accuracy trade-off for the C8 tones compared to C4 ones: subjects were slower, and their throughput performance decreased with the C8 while their error rate decreased. Still, for larger targets there was no speed-accuracy trade-off, and subjects were only slower with C8 tones. Overall, the frequency of the feedback had a significant impact on the user's performance. We thus suggest that practitioners, developers, and designers report the frequency they used in their VR applications.
[The prospects for children with acute lymphoblastic leukemia of being cured has increased in the Czech Republic in the 21st century to 90% - outcome of the ALL-IC BFM 2002 trial]. (2015)

In comparison with the previous trial ALL-BFM 95, significant improvement was achieved.
Correction: Enhancer of Zeste Homolog 2 Induces Pulmonary Artery Smooth Muscle Cell Proliferation (2012)

Introduction: Pulmonary Arterial Hypertension (PAH) is a progressively devastating disease characterized by excessive proliferation of the Pulmonary Arterial Smooth Muscle Cells (PASMCs). Studies suggest that PAH and cancers share an apoptosis-resistant state featuring excessive cell proliferation. The proliferation of cancer cells is mediated by increased expression of Enhancer of Zeste Homolog 2 (EZH2), a mammalian histone methyltransferase that contributes to the epigenetic silencing of target genes. However, the role of EZH2 in PAH has not been studied. In this study, it is hypothesized that EZH2 could play a role in the proliferation of PASMCs.
Potential of attenuated respiratory syncytial virus vaccine for infants and children. (1975)

Respiratory syncytial virus (RSV) disease is a major cause of death and hospitalization in infancy and a frequent cause of morbidity throughout childhood. Serum antibody does not protect as is evident from the study of natural disease and use of killed vaccines. Local antibody responses occur in natural illness. Possibly serum antibody in the absence of local antibody plays a part in illness. We have studied local and serum antibody response to potential attenuated vaccines: a 26 degrees C adapted RSV and a ts mutant RSV. Both produced the desired infection as evidenced by virus recovery, serum and local antibody response. However, both appear to have had residual pathogenicity for young infants. This included mild bronchitis after the 26 degrees C RSV and mild rhinitis, which might be acceptable, but also fever and otitis in one infant after the ts RSV. Also, some of the virus recovered in the ts studies had wild type characteristics. An acceptable RSV vaccine strain will (a) infect without undergoing reversion or other genetic changes, (b) induce resistance to wild type virus, (c) cause no or very mild inflammatory changes such as the rhinitis associated with the vaccines thus far tried.
Stochastic Modeling for Studies of Real-World PHEV Usage: Driving Schedule and Daily Temporal Distributions (2011)

Daily driving missions provide the fundamental information required to predict the impact of the plug-in hybrid electric vehicle (PHEV) on the grid. In this paper, we propose a statistical modeling approach of daily driving mission sets. The approach consists of temporal distribution modeling and the synthesis of individual representative cycles. The proposed temporal distribution model can capture departure and arrival time distributions with a small number of samples by statistically relating the distributions. Then, representative naturalistic cycles are constructed through a stochastic process and a subsequent statistical analysis with respect to driving distance. They are randomly assigned to the temporal distribution model to build up complete daily driving missions. The proposed approach enables the assessment of the impact on the grid of a large-scale deployment of PHEVs using a small number of simulations capturing real-world driving patterns and the temporal distributions of departure and arrival times.
Vaccines for sexually transmitted diseases (1996)

Some progress has been made in understanding the pathogenesis of a number of sexually transmitted diseases. The unique evasion strategies which this group of pathogens utilize make vaccine development particularly difficult. There are considerable efforts now being directed at the possibility of human immunogenicity testing of a gonococcal porin vaccine. While considerable work needs to be done, it appears reasonable that Chlamydia trachomatis major outer membrane protein may be a future vaccine antigen. The identification of a Haemophilus ducreyi toxin which may play a role in ulcer formation enhances the possibility that an antitoxin type vaccine might be feasible to prevent ulcers. The gD2 herpes simplex vaccine trials have shown promise that recurrent viral infections may be controlled.
Advanced HEV Architectures and Dynamics of HEV Powertrain (2011)

Many modern hybrid electric vehicles use planetary geartrain to achieve electric continuous variable transmission (e-CVT). This chapter first discusses the principle of planetary geartrain. It then looks at various hybrid transmissions, including the Toyota Prius, Ford Escape, GM-Two-Mode hybrid, dual clutch hybrid transmission, Timken hybrid, Renault hybrid, Toyota Highlander hybrid, Camry hybrid, Tasi, and Zhang's hybrid. Finally, the operation principle of the Chevy Volt range extended electric vehicle is discussed in detail. Dynamics of planetary gear based hybrid are briefly introduced. Mode transition of various hybrid transmissions is discussed in detail.
An LPV control approach for comfort and suspension travel improvements of semi-active suspension systems (2010)

In this paper, we present a new H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">∞</sub> /LPV control method to improve the trade-off between comfort and suspension travel. Firstly, a semi-active automotive suspension equipped with a nonlinear static semi-active damper is presented. Secondly, the semi-active suspension system is reformulated in the LPV framework which can be handled in a polytopic way. Finally, in numerical analysis, to emphasize the performance of the proposed controller, the end-stop event is introduced. The results show that the proposed method provides a good improvement in comfort and suspension travel compared with other strategies.
Temperature-dependent mechanical-resonance frequencies and damping in ensembles of gallium nitride nanowires (2012)

We have measured singly clamped cantilever mechanical-resonances in ensembles of as-grown gallium nitride nanowires (GaN NWs), from 12 K to 320 K. Resonance frequencies are approximately linearly dependent on temperature near 300 K with relative shifts of 40 ± 20 ppm/K, consistent with temperature-dependent elastic moduli. Below 100 K, we find that some GaN NWs have mechanical quality factors well above 400 000, at mechanical resonance frequencies near 1 MHz. We also observe a correlation between increased amplitude of dissipation and increased temperature dependence of resonance frequencies. The microwave homodyne detection technique we use is simple, allows for the investigation of as-grown or processed NWs, and is sensitive enough to observe the thermal motion of individual NWs while providing for the simultaneous measurement of large ensembles of NW mechanical resonances.
Comparative study of NOTES alone vs. EUS-guided NOTES procedures (2008)

EUS guidance appears to be helpful in gaining access or identifying structures in anatomically difficult areas in NOTES procedures.
azizilab/starfysh: STARFYSH (2022)

STARFYSH model v 1.0.0 : Spatial Transcriptomic Analysis using Reference-Free auxiliarY deep generative modeling and Shared Histology
Sonodynamically induced cell damage and membrane lipid peroxidation by novel porphyrin derivative, DCPH-P-Na(I). (2010)

The enhancement of both rates with DCPH-P-Na(I) was suppressed by 10 mM histidine. These results suggest that ultrasonically generated active oxygen plays a primary role in the ultrasonically induced cell damage in the presence of DCPH-P-Na(I).
Protein kinase activities in immune complexes of simian virus 40 large T-antigen and transformation-associated cellular p53 protein. (1984)

Immune complex kinase assays in the simian virus 40 system were performed by incubation of immunoprecipitates containing tumor antigens with [gamma-32P]ATP, followed by analysis of any phosphoacceptor proteins. These assays yielded mainly the viral large T-antigen and, in particular, the associated cellular p53 as endogenous substrates. The nature of these substrates was confirmed by proteolysis techniques. Under specific conditions, casein could be used as an exogenous substrate as well. The kinase reactions showed preference for ATP and MgCl2 instead of GTP or MnCl2. Both phosphoserine and phosphothreonine, but in no case phosphotyrosine, were detected after an immune complex kinase reaction. Apparently, several in vivo phosphorylation sites were recognized in vitro in both large T-antigen and p53, but the presence of some artifactual sites could not be completely excluded. Although contaminating kinases were detectable in the immune complexes, at least the p53 molecules were phosphorylated in vitro in a more specific way. This followed from several characteristics of the immune complex kinase reactions and especially from the strong inhibition of p53 phosphorylation by two anti-large-T monoclonal antibodies. It was shown that large T-antigen showed associated kinase activity, although none of our results could unambiguously demonstrate an intrinsic kinase activity of this protein. Finally, anti-p53 monoclonal antibodies only slightly affected in vitro phosphorylation reactions, whereas a p53 molecule from a simian virus 40-free, chemically transformed human cell line was not phosphorylated in vitro under any condition tested. Thus, it is highly unlikely that the p53 molecule per se carries intrinsic or even associated kinase activities.
Catalytic C—H Functionalization Driven by CO as a Stoichiometric Reductant: Application to Carbazole Synthesis. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
AGrimlink: the association between subclinical atherosclerosis and epigenetic age (2023)

A potential mediatory role for systemic inflammation in the association between subclinical atherosclerosis and Grim epigenetic age acceleration, identified by multi-omics analyses utilizing participants in the Progression of Early Subclinical Atherosclerosis (PESA) study.
Sonochemical Synthesis under a Magnetic Field:  Structuring Magnetite Nanoparticles and the Destabilization of a Colloidal Magnetic Aqueous Solution under a Magnetic Field (2007)

This work is devoted to the investigation of the effect of an external magnetic field (MF) applied to a sonochemical synthesis. The paper presents results on the preparation of both aggregated magnetite nanoparticles and the destabilization of a magnetite hydrosol that is formed without a MF. The results reveal a difference in morphology, size, and magnetic properties of the product obtained under a MF. They also show that the applied magnetic field affects the stabilization mechanism of the magnetite particles in an aqueous solution and destroys the stable hydrosol formed without a MF. Instead, the formation of tree-like, aggregated structures composed of small particles is observed.
Depth-dependent phase change in Gd2O3 epitaxial layers under ion irradiation (2015)

Epitaxial Gd2O3 thin layers with the cubic structure were irradiated with 4-MeV Au2+ ions in the 1013–1015 cm−2 fluence range. X-ray diffraction indicates that ion irradiation induces a cubic to monoclinic phase change. Strikingly, although the energy-deposition profile of the Au2+ ions is constant over the layer thickness, this phase transformation is depth-dependent, as revealed by a combined X-ray diffraction and ion channeling analysis. In fact, the transition initiates very close to the surface and propagates inwards, which can be explained by an assisted migration process of irradiation-induced defects. This result is promising for developing a method to control the thickness of the rare-earth oxide crystalline phases.
Purple membrane suspensions: a natural random nonlinear photonic bandgap material (2000)

The coherent and incoherent contribution to the nonlinear light scattering and the difference in angular dependence between linear and nonlinear light scattering from suspensions of bacteriorhodopsin show that this material exhibits nonlinear photonic bandgap properties.
ChemInform Abstract: ISOLATION AND CHARACTERIZATION OF THE TRICHOVERROIDS AND NEW RORIDINS AND VERRUCARINS (1982)

Abstract Zahlreiche Naturstoffe des Typs (I) werden isoliert, modifiziert und identi‐ fiziert.
Performance of dropout correction on real magnetic tape waveforms with dropouts (2001)

The need to increase both linear and track densities in tape recording technology calls for more robustness against dropouts, the sporadic losses in signal amplitude, that are a principal source of errors in tape systems. A dropout correction scheme previously introduced by the authors enables more robust bit detection by restoring the signal afflicted by the dropout event. In this paper, we present the results of using this scheme on real oversampled waveforms from an experimental tape test stand. Real-time implementation using a peak detector has been simulated in this work, Albeit at a low density (1.85 channel bits per PW50), the emphasis of this study is to identify the types of error events caused by dropouts and to demonstrate the feasibility of dropout compensation even in the case of very challenging dropouts presented by the experimental data set. It is shown that this scheme can significantly reduce the frequency of dropout induced cycle slip error events that can be as long as the data block. In other cases, where cycle slip errors do not occur, the number of errors associated with dropout events is reduced, on average, by a factor of more than 2. The sensitivity of the method to the envelope detection method is examined, and this is identified as an opportunity for significantly improving the performance of the scheme.
Dynamic Function after Anterior Cruciate Ligament Reconstruction with Autologous Patellar Tendon (2001)

The purpose of this study was to dynamically assess the functional outcome of patients who had undergone successful anterior cruciate ligament reconstruction using an autologous patellar tendon technique and to determine whether their dynamic knee function was related to quadriceps and hamstring muscle strength. The knee kinematics and kinetics of 22 subjects who had undergone anterior cruciate ligament reconstruction (mean age, 27 +/- 11 years) and of 22 age- and sex-matched healthy control subjects were determined during various dynamic activities using a computerized motion analysis and force plate system. The differences in the sagittal plane angles and external moments between the two groups during light (walking), moderate (climbing and descending stairs), and higher-demand (jogging, jog and cut, jog and stop) activities were related to isokinetic strength measurements. Although patients who are asymptomatic and functioning well after anterior cruciate ligament reconstruction can perform normally in light activities, higher-demand activities reveal persistent functional adaptations that require further study.
Image restoration with high resolution adaptive optical imaging system (2004)

The challenge in producing a clear retinal image lies in the design of the imaging system that can reduce the strong aberrations of the human eye and the photographer's expertise in adjusting the fundus camera when the image is taken. A technique that combines an advanced adaptive optical system and image post-processing algorithm has been shown to be able to significantly improve the image quality up to 2-5 times higher resolution than currently used clinical devices. The optical system has been designed to suppress low-order aberrations and enhance the precision of the wavefront measurement. Image post-processing mainly involves deconvolution by calculating the system transfer function (here the optical transfer function (OTF)) from the data obtained by the Shack-Hartman wavefront sensor.