gebhart/patrepeval huggingface dataset:
Immune cell populations in cutaneous delayed-type hypersensitivity. (1983)

Delayed-type hypersensitivity (DTH) is a prototypic T lymphocyte-mediated response to antigenic challenge. In this study, mononuclear cells infiltrating the skin during cutaneous response to tuberculin in presensitized human subjects (responders) and nonimmune controls were identified using monoclonal antibodies by indirect immunofluorescence. In both responders and controls the infiltrate consisted mainly of T lymphocytes (T11+ and OKT3+) and monocytes (OKM1+, 63D3+, Mo2+) which initially accumulated in proximity to small blood vessels and later infiltrated the interstitial dermis and epidermis. More T lymphocytes reacted with OKT4 than with OKT8. 6 h after tuberculin the ratio of OKT4/OKT8 in tissue from responders exceeded that in blood, whereas in tissues studied at 15-48 h and in all control tissues those ratios in blood and tissue were similar. Evidence of T lymphocyte activation was sought using monoclonal antibodies anti-Tac, OKT9, and OKT10. In responders but not in controls the proportion of infiltrating cells reactive with these antibodies increased during the course of DTH. The presence of activated T lymphocytes in tissue was not associated with a comparable increase in peripheral blood cell populations identified by anti-Tac and OKT10. Studies using anti-B1, Leu-7, and anti-IgD/IgM revealed comparatively few reactive cells. Dual-labeling studies demonstrated that most Leu-7--reactive cells also bound T11 while fewer bound OKM1 or OKT8 and that cells reactive with OKIa1 and T11 constituted largely nonoverlapping populations. Specific patterns of reactivity were not observed when tissues were stained with anti-human C3, or poly C9-MA, a monoclonal antibody reactive with a neoantigen on polymerized C9 of the membrane attack complex of complement. The number of epidermal Langerhans cells identified by OKT6 was similar in responders and controls. Thus, the cutaneous response to tuberculin in sensitized individuals is characterized by early enrichment of the OKT4 subpopulation of T lymphocytes in tissue infiltrates and subsequent (15-48 h) evidence of T lymphocyte activation.
Attention-based video reframing: Validation using eye-tracking (2008)

Watching TV shows on cell phones is starting to become a reality. Nevertheless, there still exist some significant issues due to the small size of cell phone screens. The direct transfer of contents that are not specifically shot for the mobile device will provide indistinguishable objects. An automated way, delivering the best viewing experience is proposed in this paper. This solution significantly improves the visual comfort, by zooming in on the regions of interest. The relevance of this solution rests on its capability to preserve the visually important areas as well as the temporal stability. Eye-tracking experiments are one metric to assess the reframing quality. Involving 16 observers, they show that more than 90% of the visually important regions are kept in the reframed clip.
Aggregation of coronene: the effect of carboxyl and amine functional groups (2020)

The aggregation of coronene is relevant to understand the formation of carbon nanomaterials, including graphene quantum dots (GQDs) that show exceptional photophysical properties. This article evaluates the influence of carboxyl and amine substituting groups on the aggregation of coronene by performing a global optimization study based on a new potential energy surface. The structures of clusters with substituted coronene are similar to those formed by un-substituted monomers, that is, stacked (non-stacked) motifs are favoured for small-size (large-size) clusters. Nonetheless, the presence of carboxyl and amine groups leads to an increase of the number of local minima of comparable energy. The clusters with substituted monomers have also shown to enhance the attractive component interaction, which can be attributed to weak induction and charge transfer effects and to stronger electrostatic contributions. Moreover, the calculated height of magic-number structures of the clusters in this work is compatible with the morphology of the GQDs reported in the literature.
DYLE: Dynamic Latent Extraction for Abstractive Long-Input Summarization (2021)

Transformer-based models have achieved state-of-the-art performance on short-input summarization. However, they still struggle with summarizing longer text. In this paper, we present DYLE, a novel dynamic latent extraction approach for abstractive long-input summarization. DYLE jointly trains an extractor and a generator and treats the extracted text snippets as the latent variable, allowing dynamic snippet-level attention weights during decoding. To provide adequate supervision, we propose simple yet effective heuristics for oracle extraction as well as a consistency loss term, which encourages the extractor to approximate the averaged dynamic weights predicted by the generator. We evaluate our method on different long-document and long-dialogue summarization tasks: GovReport, QMSum, and arXiv. Experiment results show that DYLE outperforms all existing methods on GovReport and QMSum, with gains up to 6.1 ROUGE, while yielding strong results on arXiv. Further analysis shows that the proposed dynamic weights provide interpretability of our generation process.
ZRC3308 monoclonal antibody cocktail shows protective efficacy in Syrian hamsters against SARS-CoV-2 infection (2021)

Abstract We have developed a monoclonal antibody (mAb) cocktail (ZRC-3308) comprising of ZRC3308-A7 and ZRC3308-B10 in the ratio 1:1 for COVID-19 treatment. The mAbs were designed to have reduced immune effector functions and increased circulation half-life. mAbs showed good binding affinities to non-competing epitopes on RBD of SARS-CoV-2 spike protein and were found neutralizing SARS-CoV-2 variants B.1, B.1.1.7, B.1.351, B.1.617.2 and B.1.617.2 AY.1 in vitro . The mAb cocktail demonstrated effective prophylactic and therapeutic activity against SARS-CoV-2 infection in Syrian hamsters. The antibody cocktail appears to be a promising candidate for the prophylactic use and for therapy in early COVID-19 cases which have not progressed to severe disease.
Application of collision detection to assess implant insertion in elbow replacement surgery (2010)

An important aspect of implant replacement of the human joint is the fit achieved between the implant and bone canal. As the implant is inserted within the medullary canal, its position and orientation is subjected to a variety of constraints introduced either by the external forces and moments applied by the surgeon or by the interaction of the implant with the cortical wall of the medullary canal. This study evaluated the implant-bone interaction of a humeral stem in elbow replacement surgery as an example, but the principles can also be applied to other joints. After converting CT scan data of the humerus to the parametric NURBS-based representation, a collision detection procedure based on existing Computer-Aided Engineering techniques was employed to control the instantaneous kinematics and dynamics of the insertion of a humeral implant in an attempt to determine its final posture within the canal. By measuring the misalignment between the native flexion-extension (FE) axis of the distal humerus and the prosthesis, a prediction was made regarding the fit between the canal and the implant. This technique was shown to be effective in predicting the final misalignment of the implant axis with respect to the native FE axis of the distal humerus using a cadaver specimen for in-vitro validation.
Synthesis and Characterization of New Organosoluble Polyamides and Polyimides Based on 2,2-Bis[4- (4-aminophenoxy)-3,5-dimethylphenyl]- hexafluoropropane (2001)

A new hexafluoro-containing diamine monomer, 2,2-bis[4-(4-aminophenoxy)-3,5-dimethylphenyl]hexafluoropropane (TBAPHP), was synthesized in three steps, starting from hexafluoroacetone sesquihydrate and 2,6-xylenol. The monomer was reacted with various aromatic dicarboxylic acids and tetracarboxylic dianhydrides to produce a series of polyamides and polyimides, respectively. The polyamides were prepared under Yamazaki reaction conditions. The polyimides were prepared by a two-stage procedure that included a ring-opening polyaddition yielding poly(amic acid)s, followed by a cyclodehydration to polyimides. The obtained polymers had inherent viscosities of 0.52–0.82 dL·g–1. All of the polymers dissolved in polar solvents, such as N-methyl-2-pyrrolidinone, N,N-dimethylacetamide, and N,N-dimethylformamide. The polyimides derived from 4,4′-oxydiphthalic anhydride and 3,3′,4,4′-benzophenonetetracarboxylic dianhydride exhibited an excellent solubility and were dissolved in cyclohexanone, pyridine, tetrahydrofuran, and chloroform. These polymers showed glass transition temperatures of 231–301°C and decomposition temperatures at 10% weight loss ranging from 470 to 495°C in nitrogen and from 473 to 505°C in air. The tough and flexible polymer films obtained from solution casting showed tensile strengths of 78–96 MPa and tensile moduli of 2.0–2.4 GPa. Polymers containing methyl substituents had higher solubilities and Tg values than those without methyl substituents. In addition, the hexafluoroisopropylidene-containing polymers exhibited a higher solubility and thermal stability than those containing isopropylidene units. UV-visible absorption spectra revealed that the polyimides showed a better transparency than the polyamides.
Identiy of brain alcohol dehydrogenase with liver alcohol dehydrogenase (1976)

A method for obtaining electrophoretically homogeneous rat liver alcohol dehydrogenase (EC 1.1.1.1) at a specific activity of 2-2.5 mumol/min per mg of protein is presented. Anti-sera prepared against the purified enzyme inhibit alcohol dehydrogenase by up to 75% and cause precipitation of virtually all the enzyme. The antisera were shown by immunoelectrophoresis of a partially purified liver homogenate to be specifically directed against alcohol dehydrogenase and were used to demonstrate that the alcohol dehydrogenases of rat brain and liver share common antigens. The total activity of alcohol dehydrogenase in rat brain homogenates is normally quite low, with as much as 10% of the total activity attributable to the activity in the blood contained within the brain; in cases of severe liver damage (induced experimentally with carbon tetrachloride) this contribution may rise to as much as 60%.
Supplementary Data from Preclinical Antitumor Efficacy of BAY 1129980—a Novel Auristatin-Based Anti-C4.4A (LYPD3) Antibody–Drug Conjugate for the Treatment of Non–Small Cell Lung Cancer (2023)

&lt;p&gt;Supplementary Information (Supplementary Methods, Supplementary Tables, Supplementary Figure Legends, and References for Supplementary Information).&lt;/p&gt;
Serum Ionized Magnesium Relation to Blood Pressure and Racial Factors (1997)

To study potential ionic factors predisposing to vascular disease in hypertension, particularly among black subjects, we used a recently developed combined magnesium and calcium specific, ion selective electrode apparatus to measure extracellular ionized calcium (Ca-ion), ionized magnesium (Mg-ion), and Ca-ion/Mg-ion ratios in the serum of fasting, nonmedicated white and black normotensive (n = 61) and hypertensive (n = 23) subjects, studied consecutively in a tertiary referral center. Both race and blood pressure status had independent effects on the distribution of Mg-ion values. Although Mg-ion levels for the group as a whole were lower in hypertensive versus in normotensive subjects (0.571+/-0.012 v 0.601+/-0.005 mmol/L; P < .01), this was only true of white subjects (0.579+/-0.021 v 0.620+/-0.006 mmol/L; P = .0095). The lack of a significant difference in Mg-ion levels between black hypertensive versus normotensive subjects (0.553+/-0.012 v 0.577+/-0.007 mmol/L, P = NS) was attributable to the significantly lower Mg-ion levels present in normotensive blacks compared to those in normotensive white subjects (0.577+/-0.007 v 0.620+/-0.006 mmol/L, P = .0001). Resultant Ca-ion/Mg-ion ratios were elevated in all black subjects and in white hypertensive subjects. These data support the presence among hypertensives and among black subjects (independently of blood pressure) of a consistent depletion of circulating magnesium and of an imbalance of calcium and magnesium that may potentiate vascular disease among these subjects.
Pressure-Induced Insulating State in Ba1-xRExIrO3 (RE = Gd, Eu) Single Crystals (2009)

BaIrO3 is a novel insulator with coexistent weak ferromagnetism, charge and spin density wave. Dilute RE doping for Ba induces a metallic state, whereas application of modest pressure readily restores an insulating state characterized by a three-order-of-magnitude increase of resistivity. Since pressure generally increases orbital overlap and broadens energy bands, a pressure-induced insulating state is not commonplace. The profoundly dissimilar responses of the ground state to light doping and low hydrostatic pressures signal an unusual, delicate interplay between structural and electronic degrees of freedom in BaIrO3.
Spin-valve heads with synthetic antiferromagnet CoFe/Ru/CoFe/IrMn (1999)

Spin-valve (SV) films Si(100)/Ta30/NiFe50/CoFe20/Cu26/CoFe23/Ru7/CoFe20/IrMn50/Ta30 (in Å) exhibit a room temperature (RT) giant magnetoresitance (GMR) ratio of 8.5% with an effective exchange pinning field (Heex) of ∼1.3 kOe and an antiferromagnetic (AF) saturation field (Hs) of ∼6.0 kOe. The synthetic spin valve shows a GMR ratio of 5.0% at 150 °C with Heex&amp;gt;500 Oe, while a conventional spin valve [Si(100)/Ta50/NiFe50/CoFe20/Cu28/CoFe22/IrMn50/Ta50 in Å] has a GMR ratio of 5.0% with Hex&amp;lt;200 Oe. The synthetic sample also showed a superior thermal stability with a RT GMR value of 6.9% (compared to 6.1% for conventional sample) after an anneal at 250 °C for 10 h. Shielded narrow track synthetic SV readers demonstrated high amplitude, large dynamic range, and excellent magnetic stability, indicating extendibility for ultrahigh density read head applications.
Abandoning Peracetic Acid-Based Dialyzer Reuse Is Associated with Improved Survival (2010)

Abandonment of peracetic-acid-based reuse was associated with improved survival and lower levels of inflammatory but not nutritional markers. Further study is needed to evaluate a potential link between dialyzer reuse, inflammation, and mortality.
ANALYSIS OF RELATIONSHIP BETWEEN INTRAOPERATIVE BLEEDING AND INTERVAL FROM BIOPSY TO ROBOTIC RADICAL PROSTATECTOMY (2009)

You have accessJournal of Urology1 Apr 2009ANALYSIS OF RELATIONSHIP BETWEEN INTRAOPERATIVE BLEEDING AND INTERVAL FROM BIOPSY TO ROBOTIC RADICAL PROSTATECTOMY Young Deuk Choi, Won Sik Ham, Won Tae Kim, Ho Song Yu, and Jin Sun Lee Young Deuk ChoiYoung Deuk Choi More articles by this author , Won Sik HamWon Sik Ham More articles by this author , Won Tae KimWon Tae Kim More articles by this author , Ho Song YuHo Song Yu More articles by this author , and Jin Sun LeeJin Sun Lee More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)61223-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "ANALYSIS OF RELATIONSHIP BETWEEN INTRAOPERATIVE BLEEDING AND INTERVAL FROM BIOPSY TO ROBOTIC RADICAL PROSTATECTOMY." The Journal of Urology, 181(4S), p. 430 © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 4SApril 2009Page: 430 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetricsAuthor Information Young Deuk Choi More articles by this author Won Sik Ham More articles by this author Won Tae Kim More articles by this author Ho Song Yu More articles by this author Jin Sun Lee More articles by this author Expand All Advertisement PDF DownloadLoading ...
Fully Automated Artificial Intelligence Assessment of Aortic Stenosis by Echocardiography (2023)

Artificial neural networks have the capacity to closely mimic human measurement of all relevant parameters in the adjudication of AS severity. Application of this AI technology may minimize interscan variability, improve interpretation and diagnosis of AS, and allow for precise and reproducible identification and management of patients with AS.
Comparative analyses of proteins from Haemophilus influenzae biofilm and planktonic populations using metabolic labeling and mass spectrometry (2014)

The present proteomic study indicates that the NTHi biofilm exists in a semi-dormant state with decreased energy metabolism and protein synthesis yet is still capable of managing oxidative stress and in acquiring necessary cofactors important for biofilm survival.
A Tunable Resonant Vibration Measurement Unit Based on a Micromachined Force Coupled Sensor-Actuator System (2006)

In this paper we present a novel microsystem for frequency selective vibration measurements in a lower frequency range. It is based on a force coupled sensor-actuator system which transforms vibration signals from a low into a high frequency range and filters the desired spectral line by means of resonance amplification. Commonly, vibration signals are detected by wideband accelerometers and subsequent fast Fourier transformation. In contrast to electronic signal transformation from a time to a frequency domain, the presented approach performs most signal conditioning in the mechanical domain. Thanks to the high Q-factor of MEMS, the signal is amplified in a very narrow band with high signal-to-noise ratio. The sense frequency can be tuned by variation of the carrier frequency and motion signals are detected by capacitive pick-up. The sensor is fabricated by BDRIE (bonding & deep reactive ion etching) silicon technology.
Unambiguous Delay-Doppler Recovery From Random Phase Coded Pulses (2021)

Pulse Doppler radars suffer from range-Doppler ambiguity that translates into a trade-off between maximal unambiguous range and velocity. Several techniques, like the multiple PRFs (MPRF) method, have been proposed to mitigate this problem. The drawback of the MPRF method is that the received samples are not processed jointly, decreasing signal to noise ratio (SNR). To overcome the drawbacks of MPRF, we employ a random pulse phase coding approach to increase the unambiguous range region while preserving the unambiguous Doppler region. Our method encodes each pulse with a random phase, varying from pulse to pulse, and then processes the received samples jointly to resolve the range ambiguity. This technique increases the SNR through joint processing without the parameter matching procedures required in the MPRF method. The recovery algorithm is designed based on orthogonal matching pursuit so that it can be directly applied to either Nyquist or sub-Nyquist samples. The unambiguous delay-Doppler recovery condition is derived with compressed sensing theory in noiseless settings. In particular, the minimal number of samples within each pulse repetition interval and the minimal number of transmit pulses are given, with respect to the number of targets and range ambiguity order. Simulations show that in both regimes of Nyquist and sub-Nyquist samples our method outperforms the popular MPRF approach in terms of hit rate.
The Relationships Between Radiation Dosage and Long-term Swallowing Kinematics and Timing in Nasopharyngeal Carcinoma Survivors (2021)

This study aimed to investigate the relationship between intensity-modulated radiation therapy (IMRT) dosimetry and swallowing kinematic and timing measures. Thirteen kinematic and timing measures of swallowing from videofluoroscopic analysis were used as outcome measures to reflect swallowing function. IMRT dosimetry was accessed for thirteen swallowing-related structures. A cohort of 44 nasopharyngeal carcinoma (NPC) survivors at least 3 years post-IMRT were recruited. The cohort had a mean age of 53.2 ± 11.9 years, 77.3% of whom were male. There was an average of 68.24 ± 14.15 months since end of IMRT; 41 (93.2%) had undergone concurrent chemotherapy. For displacement measures, female sex and higher doses to the cricopharyngeus, glottic larynx, and base of tongue were associated with reduced hyolaryngeal excursion and pharyngeal constriction, and more residue. For timing measures, higher dose to the genioglossus was associated with reduced processing time at all stages of the swallow. The inferior pharyngeal constrictor emerged with a distinctly different pattern of association with mean radiation dosage compared to other structures. Greater changes to swallowing kinematics and timing were observed for pudding thick consistency than thin liquid. Increasing radiation dosage to swallowing-related structures is associated with reduced swallowing kinematics. However, not all structures are affected the same way, therefore organ sparing during treatment planning for IMRT needs to consider function rather than focusing on select muscles. Dose-response relationships should be investigated with a comprehensive set of swallowing structures to capture the holistic process of swallowing.
Larger intercellular variation in (Q/R) editing of GluR6 than GluR5 revealed by single cell RT-PCR (2000)

RNA editing of the pre-mRNA encoding the kainate receptor subtypes determines the Ca2+ permeability and the rectifying properties of the receptors in which these are assembled. GluR6 pre-mRNA contains three characterized editing sites: Q/R, IN and the Y/C, whereas GluR5 pre-mRNA contains only the (Q/R) site. Single cell RT-PCR was used on cultured cortical neurons to determine the relative expression and editing levels of the kainate receptor subunits encoding mRNA. The analysis showed a large intercellular variation in editing efficiency. The overall lower level of GluR5 editing, in the culture, compared to GluR6 editing is a result of an approximately 60% lower editing efficiency of GluR5 pre-mRNA, within single cells, compared with GluR6.