gebhart/patrepeval huggingface dataset:
Data from Combining an Alarmin HMGN1 Peptide with PD-L1 Blockade Results in Robust Antitumor Effects with a Concomitant Increase of Stem-Like/Progenitor Exhausted CD8<sup>+</sup> T Cells (2023)

&lt;div&gt;Abstract&lt;p&gt;The expansion of intratumoral stem-like/progenitor exhausted CD8&lt;sup&gt;+&lt;/sup&gt; T (Tstem/Tpex) cells provides a potential approach to improve the therapeutic efficacy of immune checkpoint blockade (ICB). Thus, here we demonstrate a strategy to facilitate Tstem/Tpex cell expansion by combining an alarmin high-mobility group nucleosome binding domain 1 (HMGN1) peptide with programmed death-ligand 1 (PD-L1) blockade. The antitumor effects of HMGN1, anti–PD-L1, and their combined treatment were monitored in the B16F10, LLC, Colon26, or EO771 tumor–bearing mice. The comprehensive immunologic analyses, such as high-dimensional flow cytometry, transcriptome analysis, and single-cell RNA-sequencing (scRNA-seq), were used to investigate the cellular and molecular mechanisms of antitumor immune responses after treatments. We identified the immunostimulatory domain (EPKRR SARLS AKPPA KVEAK PKK) on HMGN1 and synthesized this domain as a therapeutic peptide (minP1). Combined treatment with minP1 and PD-L1 blockade induced durable tumor regression in tumor-bearing mice. minP1 increased the number of intratumoral mature DCs enriched in immunoregulatory molecules (mregDC) and enhanced their MHC class I antigen–presenting program. minP1 also synergized with PD-L1 blockade in augmenting intratumoral Tstem/Tpex cell number. Analysis of our scRNA-seq dataset by CellPhonDB suggested potential interactions between mregDCs and Tstem/Tpex cells in tumors. Our results indicate that HMGN1 peptide (minP1) serves as an immunoadjuvant to promote effective anti–PD-L1 immunotherapy with increased Tstem/Tpex cells in tumors.&lt;/p&gt;&lt;/div&gt;
[Anuria in HIV+ patients treated with indinavir]. (2000)

Severe acute renal failure is an uncommon complication in HIV+ patients treated with indinavir. This drug has a great tendency to precipitate in urine. The severity of the crystalluria depends on the drug dose and urinary pH, and can cause tubulointerstitial nephritis and urinary calculi with obstruction of the urinary tract.
In situ compatibilisation of alkenyl-terminated polymer blends using cross metathesis (2015)

A whiff of diblocks is enough! Straightforward coupling of two vinyl-terminated macromolecules was achieved by cross metathesis (CM) using Grubbs' second-generation catalyst (G2) giving access to a diversity of “self-compatibilised” polymer blends. Solution blends, in the absence of G2, showed clear macrophase separation while metathesized samples no longer did. A small fraction of diblocks only proved to act as an excellent compatibilizer.
Cyclic Prefix (CP) Jamming Against Eavesdropping Relays in OFDM Systems (2021)

Cooperative communication has been widely used to provide spatial diversity benefits for low-end user equipments, especially in ad hoc and wireless sensor networks. However, the lack of strong authentication mechanisms in these networks leaves them prone to eavesdropping relays. In this paper, we propose a secure orthogonal frequency division multiplexing (OFDM) transmission scheme, where the destination node transmits a jamming signal over the cyclic prefix (CP) duration of the received signal. Simulation results verify that as long as at least a part of the jamming signal falls to the actual data portion of the eavesdropping relay, it spreads through all the data symbols due to the fast Fourier transformation (FFT) operation, resulting in degraded interception at the eavesdropper.
Supplementary Information Figures 1-10, Videos 1-8 from Autocrine Fibronectin Inhibits Breast Cancer Metastasis (2023)

&lt;p&gt;S1. Differential fluorescent labeling of epithelial and mesenchymal cells. S2. Ca1h cells are not metastatic. S3. Fibronectin coated polystyrene induces a partial epithelialmesenchymal transition. S4. Fibronectin is in a fibular form in patient tumors. S5. Fibrillar fibronectin induction of EMT is dependent on the expression of b1 integrin. S6. Fibrillar fibronectin induces a mesenchymal phenotype. S7. Depletion of b1 increases intracellular FN. S8. Intracellular FN colocalizes with the actin cytoskeleton. S9. Systemically dormant cells express intracellular FN. S10.Depletion of FN increases pulmonary tumor proliferation.&lt;/p&gt;
Protein removal from fish mince washwater using ohmic heating (2008)

A static ohmic heating system was developed to remove protein from fish mince (threadfin bream) washwatercollected from a surimi production plant in order to improve water quality. The samples were heated under different electricfield strengths (EFS, 20, 25, and 30 V/cm) until reaching the desired temperature (50, 60, and 70oC), and further held at thattemperature for a certain time (0, 15, and 30 minutes). Heating the samples to 70oC resulted in a better protein removal whencompared to 50 and 60oC. After heating to 70oC, the samples were centrifuged. The analysis of the supernatant obtained showsthe reduction of protein, COD, BOD, TS, and TDS to 42%, 25%, 23%, 44%, and 61%, respectively. The electrical conductivityof the samples showed a linear relationship with temperature and the temperature demonstrated a parabolic relationshipwith heating time. EFS and holding time have no significant effect on protein removal.
Head Related Transfer Functions Interpolation Considering Acoustics (2005)

We are proposing an interpolation technique for head related transfer functions (HRTFs). For deriving the algorithm we study the dual problem where sound is emitted from the listener’s ear and the generated sound field is recorded along a circular array of microphones around the listener. The proposed interpolation algorithm is based on the observation that spatial bandwidth of the measured sound along the circular array is limited (for all practical purposes). Further, we observe that this spatial bandwidth increases linearly with the frequency of the emitted sound. The result of the analysis leads to the conclusion that the necessary angle between HRTFs is about 5 degrees in order to be able to reconstruct all HRTFs up to 44.1 kHz in the horizontal plane.
Abstract 19806: Left Atrial Remodeling in Hypertrophic Cardiomyopathy and Markers for Atrial Fibrillation: Assessment by Cardiovascular Magnetic Resonance Imaging (2012)

Introduction. Atrial fibrillation (AF) is the most common sustained arrhythmia in hypertrophic cardiomyopathy (HCM), and an important determinant of clinical deterioration due primarily to heart failure and embolic stroke Hypothesis. Left atrial (LA) structural and functional parameters were assessed with high resolution cardiovascular magnetic resonance imaging (CMR) to provide imaging markers associated with the risk for developing AF in HCM patients. Methods. We studied 438 consecutive HCM patients (age 47 17 years) with CMR, including 57 with a history of paroxysmal AF, 13 in persistent AF, 368 without AF history, as well as 244 normal controls. The LA chamber was assessed for absolute and indexed end-diastolic volume (LAEDV) and end-systolic volume (LAESV), and % ejection fraction (LAEF). Results. Absolute LAEDV was significantly greater in HCM patients with AF (157 ± 73 ml) than in patients without AF (109 ± 39 ml), or normal controls (80 ± 24 ml; p &lt; 0.001). LAEF was lower in HCM with AF (34 ± 17%) than in HCM without AF (46 ± 12%) or controls (55 ± 9%; p &lt; 0.001), and decreased progressively from control values to HCM without AF to HCM with paroxysmal AF (37 ±16 ml), and to those patients with persistent/chronic AF (18 ±13%; p &lt; 0.001). A multivariate model showed LAEF (&lt; 40%) and LAEDV (&gt; 125 ml), as well as age (&gt; 46 years) each to be independently associated with occurrence of AF. Combining these 3 CMR variables most accurately discriminated the susceptibility to AF with the area under ROC curve = 0.805, and the accuracy = 82%. Conclusions. In HCM, % LAEF, as assessed by CMR, is a novel marker associated with AF, and in conjunction with increased LAEDV and older age.
Figure S2 from Cobomarsen, an Oligonucleotide Inhibitor of miR-155, Slows DLBCL Tumor Cell Growth <i>In Vitro</i> and <i>In Vivo</i> (2023)

&lt;p&gt;Supplementary figure S2&lt;/p&gt;
Broadband Continuous-Variable Entanglement Generation Using a Kerr-Free Josephson Metamaterial (2022)

Generation of quantum resources like entanglement is pivotal for quantum technology. This work uses superconducting Josephson metamaterials to generate color-entangled photons from vacuum fluctuations at a high rate, showing the presented system to be a superb microwave entanglement generator with remarkable bandwidth. Successful squeezing of the light is also demonstrated. These results are quite promising for quantum computing, sensing, and communication with superconducting devices.
p85 Associates with Unphosphorylated PTEN and the PTEN-Associated Complex (2009)

The lipid phosphatase PTEN functions as a tumor suppressor by dephosphorylating the D3 position of phosphoinositide-3,4,5-trisphosphate, thereby negatively regulating the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway. In mammalian cells, PTEN exists either as a monomer or as a part of a >600-kDa complex (the PTEN-associated complex [PAC]). Previous studies suggest that the antagonism of PI3K/AKT signaling by PTEN may be mediated by a nonphosphorylated form of the protein resident within the multiprotein complex. Here we show that PTEN associates with p85, the regulatory subunit of PI3K. Using newly generated antibodies, we demonstrate that this PTEN-p85 association involves the unphosphorylated form of PTEN engaged within the PAC and also includes the p110beta isoform of PI3K. The PTEN-p85 association is enhanced by trastuzumab treatment and linked to a decline in AKT phosphorylation in some ERBB2-amplified breast cancer cell lines. Together, these results suggest that integration of p85 into the PAC may provide a novel means of downregulating the PI3K/AKT pathway.
MIMO directional modulation M-QAM precoding for transceivers performance enhancement (2017)

The increasing mobile data traffic requires network coverage expansion and rate enhancement. However, this demands more power and results in environmental pollution. As a solution, directional modulation can be used to provide efficient and interference-free communications. In this work, we geometrically model the extended detection regions of M-QAM modulation for M = 4, 8, 16, 32 and use these modeled regions to design energy efficient symbol-level precoders for an interference-free MIMO directional modulation transceiver. We formulate and transform the precoder design problems into linearly constrained quadratic programming optimization problems. The simulation results show that compared with the benchmark schemes, directional modulation results in lower power consumption and symbol error rate using the less stringent extended detection regions and interference-free capability, respectively.
Multipixel x ray detection integrated at the end of a narrow multicore fiber (2023)

We introduce and demonstrate the concept of a multipixel detector integrated at the tip of an individual multicore fiber. A pixel consists here of an aluminum-coated polymer microtip incorporating a scintillating powder. Upon irradiation, the luminescence released by the scintillators is efficiently transferred into the fiber cores owing to the specifically elongated metal-coated tips that ensure efficient luminescence matching to the fiber modes. With each pixel being selectively coupled to one of the cores of the multicore optical fiber, the resulting fiber-integrated x ray detection process is totally free from inter-pixel cross talk. Our approach holds promise for fiber-integrated probes and cameras for remote x and gamma ray analysis and imaging in hard-to-reach environments.
Distinct Conformations of the Chemokine Receptor CCR4 with Implications for Its Targeting in Allergy (2014)

CC chemokine receptor 4 (CCR4) is expressed by Th2 and regulatory T cells and directs their migration along gradients of the chemokines CCL17 and CCL22. Both chemokines and receptor are upregulated in allergic disease, making CCR4 a therapeutic target for the treatment of allergy. We set out to assess the mechanisms underlying a previous report that CCL22 is a dominant ligand of CCR4, which may have implications for its therapeutic targeting. Human T cells expressing endogenous CCR4 and transfectants engineered to express CCR4 were assessed for receptor function, using assays of calcium release, chemotaxis, receptor endocytosis, and ligand binding. Despite the two ligands having equal potency in calcium flux and chemotaxis assays, CCL22 showed dominance in both receptor endocytosis assays and heterologous competitive binding assays. Using two different CCR4-specific Abs, we showed that CCR4 exists in at least two distinct conformations, which are differentially activated by ligand. A major population is activated by both CCL17 and CCL22, whereas a minor population is activated only by CCL22. Mutation of a single C-terminal residue K310 within a putative CCR4 antagonist binding site ablated activation of CCR4 by CCL17, but not by CCL22, despite having no effect on the binding of either ligand. We conclude that CCL17 and CCL22 are conformationally selective ligands of CCR4 and interact with the receptor by substantially different mechanisms. This finding suggests that the selective blockade of CCR4 in allergy may be feasible when one CCR4 ligand dominates, allowing the inhibition of Th2 signaling via one ligand while sparing regulatory T cell recruitment via another.
A 1.2V low leakage low cost 90 nm CMOS wireless technology with a 60 nm transistor gate length (2004)

In this paper, we have demonstrated a low-leakage low-cost 90 nm technology with a 60 nm gate length for high performance operation by using 193 nm strong-phase-shift lithography, nitrided gate oxide, aggressively scaled MDD junctions and 6-level Cu/low-k interconnects.
New Spiro‐Phenylpyrazole/Dibenzosuberene Derivatives as Hole‐Transporting Material for Perovskite Solar Cells (2019)

A series of spiro‐arranged hole‐transporting materials are designed and synthesized by incorporating a substituted phenylpyrazole unit to the orthogonal dibenzosuberene core unit, which are named as THY‐1 to THY‐5. All of them exhibit good optical, electrochemical, and electronic properties as needed for HTMs, despite the distinctive morphologies observed for the spin‐casted thin film. A perovskite solar cell based on THY‐5 exhibits the highest power conversion efficiency of 15.83%, which is comparable to that of the N2,N2,N2′,N2′,N7,N7,N7′,N7′‐octakis(4‐methoxyphenyl)‐9,9′‐spirobi[9H‐fluorene]‐2,2′,7,7′‐tetramine (Spiro‐OMeTAD) reference device (16.22%) fabricated using identical architecture.
Design and Evaluation of Nonfluorous CO2-Soluble Oligomers and Polymers (2009)

Ab initio molecular modeling is used to design nonfluorous polymers that are potentially soluble in liquid CO2. We have used calculations to design three nonfluorous compounds meant to model the monomeric repeat units of polymers that exhibit multiple favorable binding sites for CO2. These compounds are methoxy isopropyl acetate, 2-methoxy ethoxy-propane, and 2-methoxy methoxy-propane. We have synthesized oligomers or polymers based on these small compounds and have tested their solubility in CO2. All three of these exhibit appreciable solubility in CO2. At 25 degrees C, oligo(3-acetoxy oxetane)6 is 5 wt % soluble at 25 MPa, the random copolymer (vinyl methoxymethyl ether30-co-vinyl acetate9) is 5 wt % soluble at 70 MPa and random copolymer (vinyl 1-methoxyethyl ether30-co-vinyl acetate9) is 3 wt % soluble at 120 MPa. These oligomers and polymers represent new additions to the very short list of nonfluorous CO2-soluble polymers. However, none of these are more soluble than poly(vinyl acetate), which exhibits the highest CO2 solubility of any known polymer containing only the elements C, H, and O.
Enhanced Ferroelectric Property of P(VDF‐TrFE‐CTFE) Film Using Room‐Temperature Crystallization for High‐Performance Ferroelectric Device Applications (2016)

The ferroelectric β-phase in a poly(vinylidenefluoride-trifluoroethylene-chlorotrifluoroethylene) film is successfully formed using a room temperature solvent-annealing process and shows enhanced ferroelectricity compared to a thermally annealed film. Applications in electronics and energy are demonstrated with significantly enhanced device performances for a solvent annealing (SA) film employed devices compared to a thermal annealing film employed due to enhanced ferroelectricity of the SA film. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Early 18F-FDG PET/CT Response Predicts Survival in Relapsed or Refractory Hodgkin Lymphoma Treated with Nivolumab (2019)

Monoclonal antibodies (mAbs) against programmed cell death 1 (PD-1), such as nivolumab and pembrolizumab, are associated with high response rates in patients with relapsed or refractory classic Hodgkin lymphoma (HL). To date, no prognostic factor for overall survival (OS) has been established with these agents in HL. We examined whether the first early response assessment evaluated using <sup>18</sup>F-FDG PET/CT may be associated with OS in this setting. <b>Methods:</b> This retrospective study included 45 patients from 34 institutions. In a masked, centralized review, 3 independent radiologists classified PET/CT scans obtained at a median of 2.0 mo (interquartile range, 1.7-3.7 mo) after nivolumab initiation using existing criteria (i.e., 2014 Lugano classification and 2016 LYRIC). Patients were classified according to 4 possible response categories: complete metabolic response (CMR), partial metabolic response (PMR), no metabolic response (NMR), or progressive metabolic disease (PMD). Because the OS of patients with NMR and PMR was similar, they were grouped together. OS was estimated using the Kaplan-Meier method and compared between groups using log-rank testing. <b>Results:</b> Eleven patients (24%) died after a median follow-up of 21.2 mo. The classification was identical between Lugano and LYRIC because all 16 progression events classified as indeterminate response per LYRIC were confirmed on subsequent evaluations. Both Lugano and LYRIC classified patients as CMR in 13 cases (29%), PMD in 16 (36%), NMR in 4 (9%), and PMR in 12 (27%). The 2-y OS probability was significantly different in patients with PMD (0.53; 95% confidence interval [95%CI], 0.32-0.87), NMR or PMR (0.80; 95%CI, 0.63-1.00), and CMR (1.00; 95%CI, 1.00-1.00) in the overall population (<i>P</i> = 0.02, 45 patients), as well as according to a landmark analysis at 3 mo (<i>P</i> = 0.05, 32 patients). <b>Conclusion:</b> In relapsed or refractory HL patients treated with anti-PD-1 mAbs, the first early PET/CT assessment using either Lugano or LYRIC predicted OS and allowed early risk stratification, suggesting that PET/CT might be used to develop risk-adapted strategies.
Handling dynamic scenes (2005)

Even though ray tracing is a relatively old and well-understood technique, its use for interactive applications is still in its infancy. Several issues of interactive applications are all but fully solved. Especially the handling of dynamic scenes in an interactive context so far has received few attention by ray tracing researchers. Ray tracing research so far almost exclusively concentrated on accelerating the process of creating a single image, which could take from minutes to hours. Most of these approaches relied on doing extensive preprocessing by building up complex data structures to accelerate the process of tracing a ray.
Color centers with exceptional properties in diamond (2021)

Due to their extraordinary properties, colour centres in diamond can be used for quantum information as well as for sensor tasks. Up to now the NV centre has been in focus. In this paper, techniques to optimize the color creation yield and methods to find new centres are considered.
Apelin, a Newly Identified Adipokine Up-Regulated by Insulin and Obesity (2005)

The results presented herein demonstrate that apelin is expressed and secreted by both human and mouse adipocytes. Apelin mRNA levels in isolated adipocytes are close to other cell types present in white adipose tissue or other organs known to express apelin such as kidney, heart, and to a lesser extent brown adipose tissue. Apelin expression is increased during adipocyte differentiation stage. A comparison of four different models of obesity in mice showed a large increase in both apelin expression in fat cells and apelin plasma levels in all the hyperinsulinemia-associated obesities and clearly demonstrated that obesity or high-fat feeding are not the main determinants of the rise of apelin expression. The lack of insulin in streptozotocin-treated mice is associated with a decreased expression of apelin in adipocytes. Furthermore, apelin expression in fat cells is strongly inhibited by fasting and recovered after refeeding, in a similar way to insulin. A direct regulation of apelin expression by insulin is observed in both human and mouse adipocytes and clearly associated with the stimulation of phosphatidylinositol 3-kinase, protein kinase C, and MAPK. These data provide evidence that insulin exerts a direct control on apelin gene expression in adipocytes. In obese patients, both plasma apelin and insulin levels were significantly higher, suggesting that the regulation of apelin by insulin could influence blood concentrations of apelin. The present work identifies apelin as a novel adipocyte endocrine secretion and focuses on its potential link with obesity-associated variations of insulin sensitivity status.
The endless universe: A brief introduction (2004)

The “cyclic model of the universe ” is a radical alternative to standard big bang/inflationary theory in which space and time exist indefinitely,