gebhart/patrepeval huggingface dataset:
Intraperitoneal Secretion of Interleukin-6 during Continuous Ambulatory Peritoneal Dialysis (1990)

Interleukin-6 (IL-6) was determined in serum and peritoneal dialysis effluent (PDE) of patients on chronic ambulatory peritoneal dialysis (CAPD) by a biological assay measuring the proliferation of the IL-6-dependent 7TD1 cell line. Six patients free of peritonitis displayed low but significant levels of IL-6 (mean ± 42 pg/ml) in PDE, while IL-6 was undetectable in serum. In 6 patients with staphylococcal peritonitis, a tremendous increase in PDE levels of IL-6 was noted (range: 5,832–37,491 pg/ml), while serum IL-6 remained either undetectable or on a low level except in one case. After 5 days of antibiotic treatment, IL-6 levels in PDE returned to basal values. We conclude that CAPD results in an intraperitoneal secretion of IL-6 which is markedly but transiently increased during peritonitis episodes.
Rhenium(VII) Oxo and Imido Complexes:  Synthesis, Structures, and Applications (1997)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRhenium(VII) Oxo and Imido Complexes: Synthesis, Structures, and ApplicationsCarlos C. Romão, Fritz E. Kühn, and Wolfgang A. HerrmannView Author Information Instituto de Tecnologia Química e Biológica, Quinta do Marquês, EAN, Apartado 127, 2780 Oeiras, Portugal, and Anorganisch-Chemisches Institut der Technischen Universität München, Lichtenbergstrasse 4, D-85747 Garching bei München, Germany Cite this: Chem. Rev. 1997, 97, 8, 3197–3246Publication Date (Web):December 18, 1997Publication History Received20 March 1997Revised18 July 1997Published online18 December 1997Published inissue 1 December 1997https://pubs.acs.org/doi/10.1021/cr9703212https://doi.org/10.1021/cr9703212research-articleACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views3616Altmetric-Citations477LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Adducts,Hydrocarbons,Ligands,Organic reactions,Reaction products Get e-Alerts
Codeword Position Index Based Sparse Code Multiple Access System (2018)

In this letter, a novel variant of sparse code multiple access (SCMA), called codeword position index-based SCMA (CPI-SCMA), is proposed. In this scheme, the information is transmitted not only by the codewords in a M-point SCMA codebook, but also by the indices of the codeword positions in a data block. As such, both the power and transmission efficiency can be improved. Furthermore, CPI-SCMA can achieve better error rate performance compares to conventional SCMA in the region of moderate and high signal-to-noise ratios.
Early Signaling by Vascular Endothelial Growth Factor and Placental Growth Factor in Human Bone Marrow-Derived Endothelial Cells Is Mediated by Superoxide (2009)

Our studies underscore the role of O(2)(-) as a critical regulator of VEGF and PlGF signal transduction initiation in endothelial cells.
Tutorial (T-1) Functional Verification 2003: Technology, Tools andMethodology (2003)

Functional verification is a key bottleneck in the costeffective design of integrated circuits. It is estimated that ver@cation in its entirep accormts.for up to 60% ofdesign resources, including duration. coinputer resources and total personnel. The three priiiiaiy methods used in logic and fiincrional veriQcation of commercial integrated circuits are siniulation, emulation and foimal ver@ztion. While it is notpossible to coinprehensively survey thefield in a short space, currentpractice in isolated aspects ofall tkiee hyes ofveriJication are discussed. All design arid i!er(fication tools work on a model of a clesigii, .for esuriiple. transaction, register tracsfer (Rr), gate, switck and transistor models. These models are defined b,y the seiiiuntics of rhe languages that describe the niodels. Buf it is not the purpose of this paper to discuss language, hut inore to discuss technologies. methodologies arid applications. h the last .five years the verification Iaiirlscape has changed somewhat. We will emphasize these changes. For esaiiiple, rhe rise oftestbench languages, the use of assertions and constraints -- rather than golden models -- and various iiiipro~~eriierits to formal verification
Polystyrene-b-Poly(tert-butyl acrylate) and Polystyrene-b-Poly(acrylic acid) Dendrimer-Like Copolymers:  Two-Dimensional Self-Assembly at the Air−Water Interface (2007)

The two-dimensional self-assembly at the air/water (A/W) interface of two dendrimer-like copolymers based on polystyrene and poly(tert-butyl acrylate) (PS-b-PtBA) or poly(acrylic acid) (PS-b-PAA) was investigated through surface pressure measurements (isotherms, isochores, and compression-expansion hysteresis experiments) and atomic force microscopy (AFM) imaging. The two dendrimer-like block copolymers have an 8-arm PS core (Mn = 10 000 g/mol, approximately 12 styrene repeat units per arm) with a 16-arm PtBA (Mn = 230 000 g/mol, approximately 112 tert-butyl acrylate repeat units per arm) or PAA (Mn = 129 000 g/mol, approximately 112 acrylic acid repeat units per arm) corona. The PS-b-PtBA sample forms stable Langmuir monolayers and aggregates into circular surface micelles up to a plateau observed in the corresponding isotherm around 24 mN/m. Beyond this threshold, the monolayers collapse above the interface, resulting in the formation of large and irregular desorbed aggregates. The PS-b-PAA sample has ionizable carboxylic acid groups, and its A/W interfacial self-assembly was therefore investigated for various subphase pH values. Under basic conditions (pH = 11), the carboxylic acid groups are deprotonated, and the PS-b-PAA sample is therefore highly water-soluble and does not form stable monolayers, instead irreversibly dissolving in the aqueous subphase. Under acidic conditions (pH = 2.5), the PS-b-PAA sample is less water-soluble and becomes surface-active. The pseudoplateau observed in the isotherm around 5 mN/m corresponds to a pancake-to-brush transition with the PAA chains dissolving in the water subphase and stretching underneath the anchoring PS cores. AFM imaging revealed the presence of circular surface micelles for low surface pressures, whereas the biphasic nature of the pseudoplateau region was confirmed with the gradual aggregation of the micellar PS cores above the PAA chains. The aggregation numbers for both samples were estimated around 3-5 dendrimer-like copolymers per circular surface micelle. These rather low values confirmed the tremendous influence of molecular architecture on the two-dimensional self-assembly of block copolymers.
A Study on Institution Improvement Plans for the National Supercomputing Joint Utilization System in South Korea (2023)

The purpose of this paper is to discover institutional gaps in the supercomputing joint utilization system that the government is actively promoting as an alternative to the problem of shortage of domestic supercomputing resources. The institutional gaps were discovered by examining the current status of laws, top-level plans, and operating guidelines related to the current joint utilization system and matching them with problems or issues that need to be resolved socially. The improvement plan for the institutional gaps was derived at a level that can be reflected in the operating guidelines of the Specialized Center and Unit Center so that the performing subject constituting the joint utilization system can directly participate and solve it. In the future, for the effective operation of the joint utilization system, we plan to promote the domestic market through the diffusion of research results and secure external technological competitiveness by reflecting the contents of institution improvement.
Distribution of Propranolol in Periocular Tissues: A Comparison of Topical and Systemic Administration (2011)

Topical administration can provide increased concentrations of propranolol in the periocular tissues and, thus, is superior to systemic administration for the treatment of periocular CH.
Locally enhanced surface plasmons and modulated “hot-spots” in nanoporous gold patterns on atomically thin MoS2 with a comparison to SiO2 substrate (2016)

Plasmonic phenomena in metals have garnered significant scientific and technological interest in the past decade. Despite many promising applications based on plasmonics, one remaining challenge is to control the surface geometry or morphology of the metallic structures, which can significantly affect the plasmonic properties of nanostructures. Here, we report the morphological modulation of gold (Au) nanopatterns on atomically thin layered molybdenum disulfide (MoS2), compared to Au nanopatterns grown on SiO2/Si substrate. We have used electron energy loss spectroscopy in a scanning transmission electron microscope to probe the locally enhanced surface plasmons in nanoporous Au patterns grown on SiO2/Si substrate as well as on single- and few-layer MoS2 flakes. Thin flakes of MoS2 as substrates significantly influence the morphology of Au patterns, which locally alters the plasmonic behavior. Features such as nanoscale pores exhibit plasmon localization with strong near fields, akin to “hot spots.” Boundary element method simulations demonstrate that the dipolar and breathing modes can be excited at different positions of the nanopatterns.
Data from SOX4 Expression in Bladder Carcinoma: Clinical Aspects and <i>In vitro</i> Functional Characterization (2023)

&lt;div&gt;Abstract&lt;p&gt;The human transcription factor SOX4 was 5-fold up-regulated in bladder tumors compared with normal tissue based on whole-genome expression profiling of 166 clinical bladder tumor samples and 27 normal urothelium samples. Using a SOX4-specific antibody, we found that the cancer cells expressed the SOX4 protein and, thus, did an evaluation of SOX4 protein expression in 2,360 bladder tumors using a tissue microarray with clinical annotation. We found a correlation (&lt;i&gt;P&lt;/i&gt; &lt; 0.05) between strong SOX4 expression and increased patient survival. When overexpressed in the bladder cell line HU609, SOX4 strongly impaired cell viability and promoted apoptosis. To characterize downstream target genes and SOX4-induced pathways, we used a time-course global expression study of the overexpressed SOX4. Analysis of the microarray data showed 130 novel SOX4-related genes, some involved in signal transduction (&lt;i&gt;MAP2K5&lt;/i&gt;), angiogenesis (&lt;i&gt;NRP2&lt;/i&gt;), and cell cycle arrest (&lt;i&gt;PIK3R3&lt;/i&gt;) and others with unknown functions (&lt;i&gt;CGI-62&lt;/i&gt;). Among the genes regulated by SOX4, 25 contained at least one SOX4-binding motif in the promoter sequence, suggesting a direct binding of SOX4. The gene set identified &lt;i&gt;in vitro&lt;/i&gt; was analyzed in the clinical bladder material and a small subset of the genes showed a high correlation to SOX4 expression. The present data suggest a role of SOX4 in the bladder cancer disease. (Cancer Res 2006; 66(7): 3434-42)&lt;/p&gt;&lt;/div&gt;
In-Situ Pore Plugging Using Nanosilica-Based Fluid System for Gas Shutoff to Maximize Oil Production (2022)

Summary A nanosilica (NS)-based fluid system was evaluated for forming in-situ glass-like material inside the matrix for permanent gas shutoff. The innovative aspect of this technique is how it turns NS into a substance that resembles glass-like material to block pores. This method involves two steps: First is pumping low-viscosity aqueous NS mixture into the formation and allowing it to gel up. Second is allowing gas production to dehydrate the NS gel to form in-situ glass-like material inside the formation. In this paper, an NS-based fluid system was assessed for pumping strategy and performance evaluation. An NS-based fluid system consists of a mixture of colloidal silica and activators. It possesses low viscosity, which assists in deeper penetration during placement. With time and temperature, it can lead to in-situ gelation to form a rigid gel to block the pore space. The NS-based fluid system was optimized using gelation tests and coreflooding tests to evaluate its performance under high-pressure, high-temperature conditions. The formation of in-situ glass-like material inside pores was analyzed using a scanning electron microscope (SEM). The gelation time can be tailored by varying the activator type and concentration to match the field operation requirements. Kinetics of colloidal silica gelation at elevated temperatures showed faster viscosity buildup as compared to a lower temperature. Before gelation, the viscosity for the NS-based fluid system was recorded as less than 5 cp at a 10 s–1 shear rate, whereas after gelation, the viscosity was increased to more than 500 cp at a 10 s–1 shear rate. Using coreflooding tests, N2 gas permeability of the Berea sandstone core was completely plugged after pumping the five times pore volume (PV) of NS-based fluid system at 200°F. During NS-based fluid system injection through the core, differential pressure was increased to only 10 psi showing better injectivity than viscous polymeric gel. The SEM images showed the presence of glass-like material filling the porosity, which showed an in-situ generation of glass-like material inside pores. After the successful placement of NS-based fluid system in one of the gas wells having sandstone formation, gas production was reduced by 65%. Polymeric fluids systems are viscous in nature, and difficult to pump deeper inside the formation, also with time, polymers tend to degrade making ineffective shutoff treatment over a period. The NS-based fluid system presented in this paper is robust, thermally stable, environmentally friendly, and can serve as an alternative to currently used conformance polymers for gas shutoff applications.
Influence of boundaries on magnetic ordering in Fe/V superlattices (2010)

We study the role of surface boundaries on the magnetic properties of ${[\text{Fe}/\text{V}]}_{n}$ superlattice structures, with $n=2--10$. Using the magneto-optical Kerr effect and polarized neutron reflectivity measurements, we examine the evolution of both the total and the layer-resolved magnetizations as a function of temperature. By varying $n$, we observe a large shift in the transition temperatures ${T}_{\text{c}}$ and a substantial change in the total magnetization critical exponent $\ensuremath{\beta}$. In particular, the thicker samples exhibit nonuniversal exponent values. By resolving the magnetization as a function of position within the superlattice, we show that this behavior arises from contributions of the surfaces. Furthermore, we attribute the large shift in ${T}_{\text{c}}$ to long-ranged interactions present in the superlattice.
Correcting errors by natural redundancy (2017)

For the storage of big data, there are significant challenges with its long-term reliability. This paper studies how to use the natural redundancy in data for error correction, and how to combine it with error-correcting codes to effectively improve data reliability. It explores several aspects of natural redundancy, including the discovery of natural redundancy in compressed data, the efficient decoding of codes with random structures, the capacity of error-correcting codes that contain natural redundancy, and the time-complexity tradeoff between source coding and channel coding.
Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells (2020)

MicroRNAs (miRNAs) are endogenous small non-coding RNAs that regulate gene expression with functional links to tumorigenesis. Hepatocellular carcinoma (HCC) is the most common type of liver cancer and it is heterogeneous in clinical outcomes and biological activities. Recently, we have identified a subset of highly invasive EpCAM+ HCC cells from AFP+ tumors with cancer stem/progenitor cell features, i.e., the abilities to self-renew, differentiate and initiate aggressive tumors in vivo. Here, using a global microarray-based microRNA profiling approach followed by validation with quantitative reverse transcription polymerase chain reaction, we have demonstrated that conserved miR-181 family members were upregulated in EpCAM+AFP+ HCCs and in EpCAM+ HCC cells isolated from AFP+ tumors. Moreover, miR-181 family members were highly expressed in embryonic livers and in isolated hepatic stem cells. Importantly, inhibition of miR-181 led to a reduction in EpCAM+ HCC cell quantity and tumor initiating ability, while exogenous miR-181 expression in HCC cells resulted in an enrichment of EpCAM+ HCC cells. We have found that miR-181 could directly target hepatic transcriptional regulators of differentiation (i.e., CDX2 and GATA6) and an inhibitor of wnt/β-catenin signaling (i.e., NLK). Taken together, our results define a novel regulatory link between miR-181s and human EpCAM+ liver cancer stem/progenitor cells and imply that molecular targeting of miR-181 may eradicate HCC.
Comparison Between Cyclic Gas Injection and Cyclic Solvent + Gas Injection (2016)

Abstract This paper shows the comparison obtained in the oil and gas production increase by cyclic gas injection produced at Provincia field and the cyclic solvent + gas injection (same field). According the composition of the production gas of Provincia Field (Table 1) used during the cyclic injection, is denominated as "rich gas", the molar fraction between C2 to C7+ is 31%. The Provincia Field is a mature field that has since the late 80's the Gas Lift as artificial lift system and for our particular case, that resource compressed gas was taken at 1000 psig to cyclically inject gas production. Besides, the cyclic gas injection &amp; cyclic solvent + gas injection technology was proved. The cyclic rich gas injection of was put in practice in 9 wells of the field and the cyclic injection + gas was applied in the well Santos 94. For our specific case, the application of both technologies in the increase of productivity obtained in Santos 94 (API Gravity 20°) is going to compare. During the total cycle of injection &amp; production of cyclic gas in Santos 94 an increase of oil production was obtained, 2134 Bls and 32,4 MMCF of gas. The oil and gas incremental production during the injection cycle of solvent + rich gas was 3232 Bls and 171 MMCF (32715 Equivalent Barrels).
Homogeneous Ruthenium catalyzed Hydrogenation of Furanoate Esters and Ether‐containing aliphatic Esters into primary Alcohols (2023)

Abstract Furanoate esters have been hydrogenated successfully with ruthenium complexes bearing tetradentate ligands in high yield, high selectivity and with a low catalyst loading. The catalysts and the reaction conditions described herein enabled the facile reduction of a variety of substituted 2‐ and 3‐furanoate esters, with the latter being never reduced before under catalytic hydrogenation conditions. Furthermore, several well‐defined ruthenium complexes were evaluated and compared, with bis‐imino complexes being the most versatile in terms of reactivity and selectivity.
Assessment of antioxidative ability in brain: technetium-99m-meso-HMPAO as an imaging agent for glutathione localization. (1996)

Technetium-99m-meso-HMPAO may be a potential tool to assess GSH content and to estimate antioxidative ability in the brain.
Abstract 3283: VB-111 a novel anti-angiogenic vector and a promising treatment for metastatic cancer in combination with other anticancer drugs (2011)

Abstract Background: VB-111 is a vascular disruptive and anti-angiogenic agent consisting of a non-replicating adenovirus vector (Ad-5, E1 deleted), which contains a novel Vascular Targeting System™, VTS™, and a fas and human tumor necrosis factor receptor chimeric transgene. This modified promoter specifically expresses the fas chimera transgene in tumor vessel endothelium, leading to targeted apoptosis. Preclinical in vitro and in vivo studies as well as a phase I clinical trial, have shown that VB-111 was safe and well tolerated, and had significant antitumor activity. We report here the results of a comprehensive set of in vivo studies of VB-111 in combination with chemotherapeutic and anti-angiogenic drugs. Methods: The safety and efficacy of VB-111 were evaluated employing the Lewis Lung metastasis model as a monotherapy, in combination with bevacizumab and in combination with Paclitaxel. Results: VB-111 was found to induce a dose dependent reduction of up to 90% in tumor burden of lung metastases in Lewis Lung metastasis model. Evaluation of the combined therapy with VB-111 and Avastin in Lewis Lung metastasis model showed no additive effect of Avastin 4 or 8 mg/kg as compared to VB-111 as a monotherapy. Additive effect was seen when mice were treated with a lower dose of VB-111 (1×10E9 VP/mouse) in combination with Paclitaxel (40mg/kg) and with higher dose of VB-111 (1×10E11 VP/mouse) with Paclitaxel (20mg/kg). No toxicity was observed as a result of the combined therapy, except for the lungs the organ weights among the different treatment groups showed minimal variation. In all the mice tested, the harvested organs were found to have normal growth pathology with no lesions or evidence of metastasis. Monotherapy with VB-111 did not result in any toxicity and combination therapy did not introduce additional toxicities. Conclusions: As previously shown, VB-111 was found to be safe and specific. VB-111 may provide additive effect to chemotherapy in a combination regimen. This will be further explored in clinical trials. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3283. doi:10.1158/1538-7445.AM2011-3283
Shape-controlled continuous synthesis of metal nanostructures (2016)

A segmented flow-based microreactor is used for the continuous production of faceted nanocrystals. Flow segmentation is proposed as a versatile tool to manipulate the reduction kinetics and control the growth of faceted nanostructures; tuning the size and shape. Switching the gas from oxygen to carbon monoxide permits the adjustment in nanostructure growth from 1D (nanorods) to 2D (nanosheets). CO is a key factor in the formation of Pd nanosheets and Pt nanocubes; operating as a second phase, a reductant, and a capping agent. This combination confines the growth to specific structures. In addition, the segmented flow microfluidic reactor inherently has the ability to operate in a reproducible manner at elevated temperatures and pressures whilst confining potentially toxic reactants, such as CO, in nanoliter slugs. This continuous system successfully synthesised Pd nanorods with an aspect ratio of 6; thin palladium nanosheets with a thickness of 1.5 nm; and Pt nanocubes with a 5.6 nm edge length, all in a synthesis time as low as 150 s.