gebhart/patrepeval huggingface dataset:
SuppTable1 from Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer (2023)

&lt;p&gt;Supplementary table 1 shows tumor classification&lt;/p&gt;
Perception of depth in pictures when viewed from the wrong distance (2012)

Pictures can create very realistic impressions of 3D scenes. However, only one viewing position—the center of projection—yields the correct retinal image for the depicted 3D scene. Viewing from the wrong angle yields depth-related shearing in the image, and viewing from the wrong distance yields depth-related compression or expansion. People can compensate well for viewing from the wrong angle. It is unclear whether people can compensate for incorrect distance: Some studies found evidence for compensation, and others did not. The stimuli in these studies differed greatly. They ranged from line drawings to photographs, with and without familiar objects. Some provided low-level cues that could have allowed subjects to perform the task correctly even though they did not exhibit compensation. To determine whether compensation for incorrect distance occurs, we conducted a psychophysical experiment in which we manipulated realism and object familiarity. We also designed the experiment so that low-level cues would not allow correct performance. The stimuli consisted of pictures of two rectangular planes joined at a hinge. The planes were textured with a regular grid. We varied the hinge angle to determine the value that appeared to be 90°. The stimuli were line drawings or realistically textured computer-generated images with and without familiar shapes. Although the angle perceived as 90° differed greatly for line drawings and realistic renderings, we found no evidence that observers could compensate for viewing from the wrong distance, even with realistic renderings containing familiar objects. If they cannot compensate for incorrect distance, why do people generally not notice distortions with everyday picture viewing? We show that people naturally tend to view pictures from nearly the correct distance in part because of the lenses used by photographers. Meeting abstract presented at VSS 2012
Flexible PAM in DWDM Transmission with Kramers-Kronig DSP (2018)

We experimentally compare 56 GBd time domain hybrid PAM (TDH-PAM) and multidimensional PAM (MM-PAM) in a DWDM single-sideband (SSB) IM/DD-transmission over 125 km SSMF for flexible data center interconnects with Kramers-Kronig reception.
Asymmetric cyclopropanation of allylic ethers: cleavage and regeneration of the chiral auxiliary (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric cyclopropanation of allylic ethers: cleavage and regeneration of the chiral auxiliaryAndre B. Charette and Bernard CoteCite this: J. Org. Chem. 1993, 58, 4, 933–936Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/jo00056a028https://doi.org/10.1021/jo00056a028research-articleACS PublicationsRequest reuse permissionsArticle Views439Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Objective measure of upper extremity motor impairment in Parkinson's disease with inertial sensors (2011)

Functional motor impairment caused by Parkinson's disease and other movement disorders is currently measured with rating scales such as the Unified Parkinson's Disease Rating Scale (UPDRS). These are typically comprised of a series of simple tasks that are visually scored by a trained rater. We developed a method to objectively quantify three upper extremity motor tasks directly with a wearable inertial sensor. Specifically, we used triaxial gyroscopes and adaptive filters to quantify how predictable and regular the signals were. We found that simply using the normalized mean squared error (NMSE) as a test statistic permitted us to distinguish between subjects with and without Parkinson's disease who were matched for age, height, and weight. A forward linear predictor based on the Kalman filter was able to attain areas under the curve (AUC) in receiver operator characteristic (ROC) curves in the range of 0.76 to 0.83. Further studies and development are warranted. This technology has the potential to more accurately measure the motor signs of Parkinson's disease. This may reduce statistical bias and variability of rating scales, which could lead to trials with fewer subjects, less cost, and shorter duration.
Ethernet based smart networked elements: sensors and actuators (2006)

This paper outlines the present design approach for the Ethernet-Based Smart Networked Elements (SNE) being developed by NASA's Instrumentation Branch and the Advanced Electronics and Technology Development Laboratory of ASRC Aerospace Corporation at Kennedy Space Center (KSC). The SNEs are being developed as part of the Integrated Intelligent Health Management System (IIHMS), jointly developed by Stennis Space Center (SSC), KSC, and Marshall Space Flight Center (MSFC). SNEs are sensors/actuators with embedded intelligence, capable of networking among themselves and with higher-level systems (external processors and controllers) to provide not only instrumentation data but also associated data validity qualifiers. NASA KSC has successfully developed and preliminarily demonstrated this new generation of SNEs. SNEs that collect pressure, strain, and temperature measurements (including cryogenic temperature ranges) have been developed and tested in the laboratory and are ready for demonstration in the field.
Call for Papers: Optical Code Division Multiple Access (2006)

Call for Papers: Optical Code Division Multiple Access Guest Editors Alan Willner, University of Southern California Janet Jackel, Telcordia Submission Deadline: 1 November 2006 Optical code division multiple access (OCDMA) is a technique in which each network user is assigned a unique code rather than a specific wavelength or time slot. This approach allows the same available bandwidth to be shared among the various users, and the code assignments can be flexibly and dynamically changed. CDMA is, of course, quite valuable in wireless systems and had been explored in the optical domain since the mid 1980s. Recently, OCDMA has received increased attention because of significant advances in the enabling technologies, optimal coding schemes, and efficient network algorithms. Due to the increase in interest and the number of published articles in OCDMA, it was felt that the time was ripe for a special issue in the Journal of Optical Networking (JON) on the topic. The research community has demonstrated advances in synchronous and asynchronous systems, based variously on manipulation of phase, frequency, time, and wavelength. A critical question remains as to the ultimate utility of OCDMA, as opposed to or in addition to time and wavelength multiplexing approaches. Applications have been proposed, ranging from PONs for FTTX to the use of codes for flexible networking and for augmented security. This special issue focuses on the technology of OCDMA and on its applications, including its use in networks, possible coexistence with other types of communications, and issues relating to the control and management of networks that incorporate OCDMA. Scope of Submission We welcome submissions on topics including, but not limited to: Novel coding concepts, algorithms, and constructions Synchronous and asynchronous implementations OCDMA-enabled network architectures, topologies, and protocols Enabling hardware Demonstrations of OCDMA Analysis of system performance enhancements Applications of OCDMA and its core technologies Key issues affecting use of OCDMA for privacy and security Comparison and coexistence of OCDMA with other multiuser schemes Manuscript Submission To submit to this special issue, follow the normal procedure for submission to JON, indicating ``OCDMA' in the ``Comments' field of the online submission form. For all other questions relating to this feature issue, please send an e-mail to jon@osa.org, subject line ``OCDMA.' Additional information can be found on the JON website: http://www.osa-jon.org/submission/.
Angkor's Multiple Southeast Asia Overland Connections (2023)

The Angkorian world included a variety of connectors that linked the capital to its provinces and more distant regions where Angkorian influence, if not direct control, shaped daily lives. Archaeological and documentary sources identify formally constructed overland roads that complemented extant riverine and coastal transportation and communication routes to move commodities and people across much of what is now mainland Southeast Asia’s upstream/downstream and coastal/inland systems. The circulation of goods through these networks not only sustained the Angkorian elite; they bolstered their relations with neighbouring polities, among them successive Chinese rulers. At its height, the Angkorian world was intensively networked. This chapter draws on extant sources to describe dynamics that shaped different routes through time, paying attention both to the Angkorian capital and major polities whose interactions with Angkor’s court are described in the epigraphy.
Searches for transverse momentum dependent flow vector fluctuations in Pb-Pb and p-Pb collisions at the LHC (2017)

The measurement of azimuthal correlations of charged particles is presented for Pb-Pb collisions at s NN = 2.76 TeV and p-Pb collisions at s NN = 5.02 TeV with the ALICE detector at the CERN Large Hadron Collider. These correlations are measured for the second, third and fourth order flow vector in the pseudorapidity region || < 0.8 as a function of centrality and transverse momentum p T using two observables, to search for evidence of p T -dependent flow vector fluctuations. For Pb-Pb collisions at 2.76 TeV, the measurements indicate that p T -dependent fluctuations are only present for the second order flow vector. Similar results have been found for p-Pb collisions at 5.02 TeV. These measurements are compared to hydrodynamic model calculations with event-by-event geometry fluctuations in the initial state to constrain the initial conditions and transport properties of the matter created in Pb-Pb and p-Pb collisions.
Transcriptional Analysis of Lennert Lymphoma Reveals a Unique Profile and Identifies Novel Therapeutic Targets (2019)

Lennert lymphoma (LL) is a lymphoepithelioid morphological variant of peripheral T-cell lymphoma-not otherwise specified (PTCL/NOS), clinically characterized by better prognosis if compared with other PTCL/NOS. Although well characterized as far as morphology and phenotype are concerned, very little is known regarding its molecular features. In this study, we investigated the transcriptional profile of this tumor aiming 1) to identify its cellular counterparts; 2) to better define its relation with other PTCLs-and, therefore, its possible position in lymphoma classification; and 3) to define pathogenetic mechanisms, possibly unveiling novel therapeutic targets. To address these issues, we performed gene and microRNA expression profiling on LL and other PTCL/NOS cases; we identified different genes and microRNAs that discriminated LL from other PTCL/NOS. Particularly, LL revealed a molecular signature significantly enriched in helper function and clearly distinguishable from other PTCL/NOS. Furthermore, PI3K/Akt/mTOR pathway emerged as novel potential therapeutic target. In conclusion, based on the already known particular morphological and clinical features, the new molecular findings support the hypothesis that LL might be classified as a separate entity. Preclinical and clinical studies testing the efficacy of PI3K/MTOR inhibitors in this setting are warranted.
Characterization of Dicarboxylic Salts of Protonated Triethylenetetramine Useful for the Treatment of Copper-Related Pathologies (2007)

X-ray crystal structures of three salts of protonated triethylenetetramine, (H4TETA)4+, with succinate, maleate, and fumarate anions are reported. Structures of the complexes (H4-triethylenetetramine)(hydrogenmaleate)4·2H2O [(H4TETA)(Hmal)4·2H2O] (1), (H4-triethylenetetramine)(hydrogenfumarate)4·3.3H2O [(H4TETA)(Hfum)4·3.3H2O] (2), and (H4-triethylenetetramine)(succinate)2 [(H4TETA)(suc)2] (3) all form assemblies of alternating two-dimensional layers of (H4TETA)4+ and the anionic species via hydrogen-bond networks. Both classical and nonclassical hydrogen bonds between the protonated amine groups, anions, and water molecules were observed. X-ray powder diffraction measurements, differential thermal analysis/thermogravimetry, density vapor sorption, and Karl Fischer titration measurements were performed to obtain confirmatory information about the water content in the structures 1 and 2 and to examine polymorphism within the salts. The nonhydrated salt 3 was determined to be the most favorable salt formulation for use in medicinal applications.
Supplementary Methods, Figures S1 - S7 from PtdIns(3,4,5)<i>P</i><sub>3</sub>-Dependent Activation of the mTORC2 Kinase Complex (2023)

&lt;p&gt;Figure S1. The Sin1-PH domain binds the mTOR kinase domain to inhibit mTOR kinase activity, Related to Figure 1. Figure S2. The PH domain is a unique and physiological functional PH domain, Related to Figure 2. Figure S3. PI(3,4,5)P3 binds the Sin1-PH motif to activate mTORC2, Related to Figure 3. Figure S4. The presence of PIP3 species leads to attenuated Sin1-PH domain interaction with mTOR-KD, Related to Figure 4. Figure S5. The Sin1-PH motif mainly interacts with PI(3,4,5)P3 through three critical residues including R393, K428 and K464, Related to Figure 5. Figure S6. The cancerous Sin1-PH mutant lose binding with the mTOR-kinase domain, leading to elevated Akt-S473 phosphorylation and enhanced oncogenic activities, Related to Figure 6. Figure S7. C-terminal tagging of KRas-CAAX to Sin1 could partially rescue the deficiency of the Sin1-CAA mutant in membrane recruitment and mTORC2 activation, Related to Figure 7.&lt;/p&gt;
Interfacial CoOx Layers on TiO2 as an Efficient Catalyst for Solvent‐Free Aerobic Oxidation of Hydrocarbons (2018)

Construction of efficient interfaces to improve the performance of supported metal catalysts is a challenging but effective technique. A newly synthesized catalyst with layered cobalt oxide on the surface of titania (layer-CoO<sub>x</sub> /TiO<sub>2</sub> ) is highly selective towards the aerobic oxidation of C-H bonds in a series of hydrocarbons under sustainable conditions. The layer-CoO<sub>x</sub> /TiO<sub>2</sub> easily outperforms the state-of-the-art noble metal catalysts and homogeneous cobalt salts used in industry. In-depth structural and functional characterization reveal that the layer-CoO<sub>x</sub> /TiO<sub>2</sub> readily reacts with O<sub>2</sub> for the adsorption and activation of C-H bonds. The layered structure of CoO<sub>x</sub> can maximize the interfacial effect of CoO<sub>x</sub> /TiO<sub>2</sub> leading to a good performance for the oxidation of C-H bonds.
Perspective: Evolutionary design of granular media and block copolymer patterns (2016)

The creation of new materials “by design” is a process that starts from desired materials properties and proceeds to identify requirements for the constituent components. Such process is challenging because it inverts the typical modeling approach, which starts from given micro-level components to predict macro-level properties. We describe how to tackle this inverse problem using concepts from evolutionary computation. These concepts have widespread applicability and open up new opportunities for design as well as discovery. Here we apply them to design tasks involving two very different classes of soft materials, shape-optimized granular media and nanopatterned block copolymer thin films.
Regulation of interleukin 3 gene induction in normal human T cells. (1989)

The regulation of IL-3 gene induction in human peripheral blood T cells was studied. IL-3 gene expression was inducible by crosslinking of the T cell receptor/CD3 complex using anti-CD3 MAb G19-4. Anti-CD3-induced IL-3 gene expression was found to be limited to the CD28+ T cell subset and could be augmented by costimulating T lymphocytes with antibodies directed against CD28. IL-3 expression could also be induced by costimulation of T cells with both phorbol ester and ionomycin, which are thought to mimic the intracellular effects of T cell receptor-antigen interaction. However, unlike other lymphokines such as IL-2 or granulocyte-macrophage colony-stimulating factor, IL-3 gene expression is not induced by stimulation of cells with phorbol myristate acetate and anti-CD28. We conclude that IL-3 gene regulation is under stringent control since IL-3 gene expression occurs only in the CD28+ subset of T cells, and since IL-3 induction obligately requires increased intracellular calcium.
Evaluation of an Outpatient Model for Treatment of Acute Myeloid Leukemia (2016)

Background: In January 2012, our center developed an ambulatory model for acute myeloid leukemia (AML) patients receiving post-induction chemotherapy. The purpose of this study was to evaluate the feasibility and safety of the outpatient leukemia program at our center. Methods: A retrospective review of all consecutive AML patients receiving a first cycle of consolidation chemotherapy in the outpatient program in 2012 was compared to similarly managed patients primarily in the inpatient setting in 2010. Results: The 2012 cohort spent more days as outpatients in comparison to the 2010 cohort (median (range): 15.5 (0 - 27) vs. 0 (0 - 10), days, P = 0.002). There was no difference between the two cohorts in terms of median overall observation time (time from start of chemotherapy until discharged to clinic), transfusion requirements, days spent neutropenic or days spent febrile. There were no documented episodes of  Clostridium difficile , clinically significant bleeding, venous thromboembolism, or death in either cohort. Conclusions: Outpatient management of AML patients receiving post-induction chemotherapy was feasible in this group of carefully selected individuals, liberating limited and costly inpatient resources for more appropriate patients. J Hematol. 2016;5(1):1-7 doi: http://dx.doi.org/10.14740/jh235w
Signaling Complexes of Voltage-Gated Calcium Channels and G Protein-Coupled Receptors (2008)

Activation of opioid or opioid-receptor-like (ORL1 a.k.a. NOP or orphanin FQ) receptors mediates analgesia through inhibition of N-type calcium channels in dorsal root ganglion (DRG) neurons (1, 2). Unlike the three types of classical mu, delta, and kappa opioid receptors, ORL1 mediates an agonist-independent inhibition of N-type calcium channels. This is mediated via the formation of a physical protein complex between the receptor and the channel, which in turn allows the channel to effectively sense a low level of constitutive receptor activity (3). Further inhibition of N-type channel activity by activation of other G protein-coupled receptors is thus precluded. ORL1 receptors, however, also undergo agonist-induced internalization into lysosomes, and channels thereby become cointernalized in a complex with ORL1. This then results in removal of N-type channels from the plasma membrane and reduced calcium entry (4). Similar signaling complexes between N-type channels and GABA(B) receptors have been reported (5). Moreover, both L-type and P/Q-type channels appear to be able to associate with certain types of G protein-coupled receptors (6, 7). Hence, interactions between receptors and voltage-gated calcium channels may be a widely applicable means to optimize receptor channel coupling.
The Role of Aluminum in Promoting Ni–Fe–OOH Electrocatalysts for the Oxygen Evolution Reaction (2019)

Nickel–iron oxyhydroxide (Ni–Fe–OOH) catalysts have been widely studied for their high activity for the oxygen evolution reaction (OER). Here we demonstrate improved OER activity through incorporation of a third cation, aluminum. Atomic layer deposition (ALD) was used to deposit thin films of nickel oxide (Ni–O) and nickel–aluminum oxide (Ni–Al–O) to measure activity for the OER. Electrochemical preconditioning of the oxide films led to the formation of the OER-active oxyhydroxide catalysts. For Ni–Al–O films, electrochemical preconditioning resulted in aluminum dissolution until a stable composition at a Ni:Al ratio of 9:1 was reached. Because iron can be incorporated into the films from the solution, compositional effects of iron were studied by controlling the iron impurity level in the electrolyte. Turnover frequencies (TOFs) were determined for each catalyst, and it was found that the highest performing electrocatalysts were the films containing nickel, aluminum, and iron, confirming that aluminum exerts a promotion effect on nickel oxyhydroxide catalysts. Studies showed that unlike the Ni–Fe–OOH films, for which the TOF had very little thickness dependence, the activity of Ni–Al–Fe–OOH catalysts was dependent on thickness. This effect may arise from morphological changes in the catalyst film that modulate the density of the active site with thickness. For the thinnest films, aluminum doping improved the TOF of Ni–Fe–OOH catalysts by over 3-fold.
Design of a Bandgap Voltage Reference Used in ∑Δ ADC (2007)

A bandgap voltage reference used in high-order ∑Δ ADC based on standard n-well 0.6 μm CMOS process was given.The influence of the offset voltage of op-amp on the reference voltage was decreased using 3 vertical BJT in series and the current mismatch was reduced by high-gain op-amp.The start-up circuit was design for the bandgap voltage reference circuit working normally.Results from simulation show that the circuit has a PSRR of 73 dB and accuracy of 9.6×10-6/℃.According to the analyses and simulation of system,the circuit completely meets the requests of high-order ∑Δ ADC.
NASICON-type Li1+2xZr2−xCax(PO4)3 with high ionic conductivity at room temperature (2011)

Compounds with nominal formula Li1+2xZr2−xCax(PO4)3 (x = 0.1–0.4) were synthesized and the substitution effects on surface morphology, density and ionic conductivity were investigated. With the introduction of Ca2+, the rhombohedral NASICON structure is retained at room temperature. The maximum Li+-ion conductivity at room temperature is 0.49 × 10−4 S cm−1 with an activation energy of 0.48 eV with x = 0.1. A Ca2+-rich grain boundary is formed with x > 0.1, which results in a significant decrease in density and ionic conductivity.