gebhart/patrepeval huggingface dataset:
Bulk growth of high-purity 6H-SiC single crystals by halide chemical-vapor deposition (2005)

High-purity 6H-SiC single crystals were grown by the halide chemical-vapor deposition process. Growth was performed in a vertical hot-wall reactor with a separate injection of a silicon precursor (silicon tetrachloride) and a carbon precursor (propane). Typical growth rates were between 100 and 300μm∕h. The crystals contain very low concentrations of residual impurities. The main contaminants, namely, nitrogen and boron, are in the 1014atomscm−3 range. Crystals grown under Si-rich conditions were n type with low room temperature electron concentrations in the 1014–1015atomscm3 range and with room-temperature electron mobilities approaching 400cm2∕Vs. The resistivity of the material increased up to 1010Ωcm with increasing C∕Si ratio. Deep levels spectra show that the electron traps density decreases with increasing C∕Si ratio.
Design of an Ultra Precision Diaphragm Flexure Stage for Out-of-Plane Motion Guidance (2004)

An ultra-precision diaphragm flexure stage was designed and optimized for pure out-of-plane Z-motion guidance with an effort to minimize parasitic lateral and tilt motions. The diaphragm flexure stage will be used to guide an objective lens along the optical axis in a high performance microscope. A concept with cross-linked radial spoke geometry akin to a bicycle wheel was designed to maximize its in-plane to out-of-plane stiffness ratio. The geometry was then optimized using finite element analysis. Several prototypes were manufactured using an abrasive water jet machining center and tested with a reconfigurable test fixture. Sets of two and four diaphragms were tested. Negligible improvement in parasitic motion was observed between the two and four-diaphragm configurations. The experimental results for out-of-plane stiffness matched the finite element result within 0.3%. Negligible hysteresis in vertical motion was observed. Maximum lateral parasitic motion on the order 2 μm was measured over a Z-motion range of 140 μm. The lateral displacement was linear (R2=0.998) and repeatable, and could be an artifact of misalignment of the diaphragms in the test fixture.
Compact microstrip-fed meander slot antenna for harmonic suppression (2003)

A novel compact microstrip-fed meander slot antenna is proposed to achieve suppression of harmonics and miniaturisation of the antenna. To obtain these characteristics, a meander-type slot radiator and U-shaped conductor line connected with the ground plane are applied. The real parts of the measured input impedance at the second- and third-harmonic frequencies are nearly zero. In the measured radiation patterns in E- and H-plane, the second- and third-harmonic suppressions are observed to be approximately less than −30 dB.
Benchmarking of Modular Multilevel Converter Topologies for ES-STATCOM Realization (2020)

In recent years, the integration of the high-power static synchronous compensator (STATCOM) and energy storage in the same device has gained interest. Such a system is referred to as ES-STATCOM. Modular multilevel converter (MMC) topologies constitute a promising converter family for ES-STATCOM realization, providing a modular and scalable solution with a high efficiency that handles high-power and high-voltage ratings in grid applications. There is a gap in technical literature discussing the design and the comparison of MMC-based ES-STATCOMs while utilizing batteries to find the most suitable MMC topology for ES-STATCOMs. Therefore, this paper benchmarks MMC family members for ES-STATCOM realization. Both centralized and distributed energy storage approaches are investigated. The proposed design flowcharts can be employed for comparison and optimization purposes. In total, seven topologies are compared in terms of number of cells, required silicon area and total battery volume. Different semiconductor devices and battery types are analyzed. The result indicates that centralized energy storage systems are the most suitable due to their design flexibility, low volume and small silicon area. Moreover, the possibility of using over-modulation in MMC using bridge cells has an important role in the optimization of ES-STATCOM. The results for the adopted case study shows that the decentralized approach can lead to 55% higher silicon area and 30% higher volume than the centralized approach. The double-star bridge cell MMC with centralized energy storage is determined as the most suitable solution for ES-STATCOM systems.
ViBE: a new paradigm for video database browsing and search (2002)

Video Browsing Environment (ViBE) is a unique browseable/searchable paradigm for organizing video databases containing a large number of sequences. The system first segments video sequences into shots by using the generalized trace obtained from the DC-sequence of the compressed data stream. Each video shot is then represented by a hierarchical tree structure of key frames, and the shots are automatically classified into predetermined pseudo-semantic classes. Finally, the results are presented to the user in an active browsing environment using a similarity pyramid data structure. The similarity pyramid allows the user to view the video database at various levels of detail. The user can also define semantic classes and reorganize the browsing environment based on relevance feedback.
Soft-landing control by control invariance and receding horizon control (2014)

We propose a design for soft landing control based on control invariant sets and receding horizon control. Soft landing control, which is of interest in several applications in aerospace, transportation systems, and factory automation, aims at achieving precise positioning of a moving object to a target position, while ensuring that the maximum velocity decreases as the target is approached. The resulting soft contact avoids damages and wear. In this paper, we formulate appropriate constraints and recast soft landing control as the generation of an admissible trajectory of the constrained system. Then, we compute a control invariant set and design a receding horizon control law that forces the state to remain in such set. Thus, the trajectories generated by the controller achieve soft landing, regardless of the controller cost function and horizon, also when the dynamics are uncertain. We demonstrate our approach by a case study in transportation systems.
Distribution of unesterified cholesterol-containing particles in human atherosclerotic lesions. (1995)

The objective of the study was to characterize unesterified cholesterol particles in human aorta and to correlate the findings with the severity of aortic atherosclerosis. Human tissues were processed under conditions that preserve deposits of unesterified cholesterol agglomerates. Filipinfluorescence was determined by using a novel triple band pass filter. The pattern of unesterified cholesterol deposits was age related and correlated with the severity of atherosclerosis. We found three types of deposits: 1), small spherulites (3 to 5 mu), which were depicted in both the media and intima in individuals as early as age 16, and which, in more advanced ages, showed an increase in density and a tendency to aggregate extracellularly throughout the intima in clusters; 2), elongated structures (10 to 30 mu in the middle zone of the intima), the density of which was directly related to the severity of atherosclerosis; and 3), large (100 mu), irregular deposits found mainly in the core of atherosclerotic plaques. The medium size deposits, compared with those found in the core of atherosclerotic plaques, retain their overall size (10 to 30 mu), uniformity (oval elongated), and localization (middle zone of the intima). On the basis of these observations we hypothesize cholesterol deposition in two stages of aggregation: 1), early degradation of infiltrating low density lipoprotein particles forming unesterified cholesterol-rich vesicles in the vessel wall, followed by aggregation to spherulites in the lower part of the intima; and 2), more massive agglomeration of particles containing unesterified cholesterol and calcium phosphate in the midzone of the intima. Because in the second stage of aggregation the transition of cholesterol to the solid state has already occurred, it is irreversible.
Team IHMC's Lessons Learned from the DARPA Robotics Challenge Trials (2015)

This article is a summary of the experiences of the Florida Institute for Human &amp; Machine Cognition (IHMC) team during the DARPA Robotics Challenge (DRC) Trials. The primary goal of the DRC is to develop robots capable of assisting humans in responding to natural and manmade disasters. The robots are expected to use standard tools and equipment to accomplish the mission. The DRC Trials consisted of eight different challenges that tested robot mobility, manipulation, and control under degraded communications and time constraints. Team IHMC competed using the Atlas humanoid robot made by Boston Dynamics. We competed against 16 international teams and placed second in the competition. This article discusses the challenges we faced in transitioning from simulation to hardware. It also discusses the lessons learned both during the competition and in the months of preparation leading up to it. The lessons address the value of reliable hardware and solid software practices. They also cover effective approaches to bipedal walking and designing for human‐robot teamwork. Lastly, the lessons present a philosophical discussion about choices related to designing robotic systems.
Impact of regular physical activity on weekly warfarin dose requirement (2015)

Warfarin is an oral anticoagulant agent with a narrow therapeutic index. There is a marked inter- and intra-patient variability in warfarin dose requirement. All factors influencing warfarin response are not known and this study aims to evaluate if regular physical activity (RPA) is a determining factor. RPA level was collected with the Stanford Brief Activity Survey in 1064 incident warfarin users, as part of the Quebec Warfarin Cohort (QWC), and with the Global Physical Activity Questionnaire in 618 patients from the Montreal Heart Institute (MHI) Biobank. Linear regression was performed to model relationship of warfarin dose after 3 months of therapy in the QWC with RPA, while controlling for height, weight, age, CYP2C9 (*2 and *3 alleles) and VKORC1 (*2 allele) genotype. Warfarin dose of prevalent users was modeled in the MHI Biobank for replication. A higher level of physical activity was associated with higher doses of warfarin in both cohorts. In the QWC, physical activity could explain 5.4 % (P < 0.001) and 0.9 % (P = 3.23 × 10(-5)) of variance in dose, in univariate and multivariable models, respectively. Similarly, RPA was found to be associated with 1.7 % (P = 0.0012) and 0.5 % (P = 0.0391) of inter-individual variability in warfarin dose requirement before and after adjustment for other covariables, respectively. RPA is associated with higher warfarin dose requirement. The relevance of clinical recommendations on RPA to maintain a steady response to warfarin should be assessed in further studies.
Search for Narrow Resonances in the b-Tagged Dijet Mass Spectrum in Proton-Proton Collisions at s=8  TeV (2018)

A search for narrow resonances decaying to bottom quark-antiquark pairs is presented, using a data sample of proton-proton collisions at sqrt[s]=8 TeV corresponding to an integrated luminosity of 19.7 fb^{-1}. The search is extended to masses lower than those reached in typical searches for resonances decaying into jet pairs at the LHC, by taking advantage of triggers that identify jets originating from bottom quarks. No significant excess of events is observed above the background predictions. Limits are set on the product of cross section and branching fraction to bottom quarks for spin 0, 1, and 2 resonances in the mass range of 325-1200 GeV. These results improve on the limits for resonances decaying into jet pairs in the 325-500 GeV mass range.
Comparative Structural Connectivity Spectra Analysis (CoSCoSA) Models of Steroid Binding to the Corticosteroid Binding Globulin (2002)

A three-dimensional quantitative spectrometric data-activity relationship (3D-QSDAR) model was developed that is built by combining NMR spectral information with structural information in a 3D-connectivity matrix. The 3D-connectivity matrix is built by displaying all possible carbon-to-carbon connections with their assigned carbon NMR chemical shifts and distances between the carbons. Selected 2D (13)C-(13)C COrrelation SpectroscopY (COSY) (through-bond nearest neighbors) and selected theoretical 2D (13)C-(13)C distance connectivity spectral slices from the 3D-connectivity matrix to produce a relationship among the spectral patterns for 30 steroids binding to corticosteroid binding globulin. We call this technique a comparative structural connectivity spectra analysis (CoSCoSA) modeling. A CoSCoSA principal component linear regression model based on the combination of (13)C-(13)C COSY and (13)C-(13)C distance spectra principal components (PCs) had an r(2) of 0.96 and a leave-one-out (LOO) cross-validation q(2) of 0.92. A CoSCoSA parallel distributed artificial neural network (PD-ANN) model based on the combination of (13)C-(13)C COSY and (13)C-(13)C distance spectra had an r(2) of 0.96, a leave-three-out q(3)(2) of 0.78, and a leave-ten-out q(10)(2) of 0.73. CoSCoSA modeling attempts to uniquely combine the quantum mechanics information from the NMR chemical shifts with internal molecular atom-to-atom distances into an accurate modeling technique. The CoSCoSA modeling technique has the flexibility and accuracy to outperform the cross-validated variance q(2) of previously published quantitative structure-activity relationship (QSAR), quantitative spectral data-activity relationship (QSDAR), self-organizing map (SOM), and electrotopological state (E-state) models.
Stimulation of the primary anti-HIV antibody response by IFN-α in patients with acute HIV-1 infection (2008)

Type I IFNs are needed for the production of antiviral antibodies in mice; whether they also stimulate primary antibody responses in vivo during human viral infections is unknown. This was assessed in patients acutely infected with HIV-1 and treated with IFN-alpha2b. Patients with acute HIV-1 infection were randomized to receive antiretroviral therapy alone (Group A, n=60) or combined for 14 weeks with pegylated-IFN-alpha2b (Group B, n=30). Emergence of anti-HIV antibodies was monitored during 32 weeks by Western blot (WB) analyses of serum samples. IFN-alpha2b treatment stimulated the production of anti-HIV antibodies. On Week 32, 19 weeks after the last IFN-alpha2b administration, there were 8.5 (6.5-10.0) HIV WB bands (median, interquartile range) in Group B and 7.0 (5.0-10.0) bands in Group A (P=0.054), and band intensities were stronger in Group B (P<0.05 for p18, p24, p34, p40, and p55 HIV antigens). IFN-alpha2b treatment also increased circulating concentrations of the B cell-activating factor of the TNF family (P<0.001) and ex vivo production of IL-12 (P<0.05), reflecting its effect on innate immune cells. Withdrawal of antiretroviral treatment on Week 36 resulted in a lower rebound of HIV replication in Group B than in Group A (P<0.05). Therefore, type I IFNs stimulate the emerging anti-HIV immune response in patients with acute HIV-1 infection, resulting in an improved control of HIV replication. Type I IFNs are thus critical in the development of efficient antiviral immune responses in humans, including the production of antiviral antibodies.
Comparative analysis of the complete genome sequences of Helicoverpa zea and Helicoverpa armigera single-nucleocapsid nucleopolyhedroviruses (2002)

The complete nucleotide sequence of Helicoverpa zea single-nucleocapsid nucleopolyhedrovirus (HzSNPV) has been determined (130869 bp) and compared to the nucleotide sequence of Helicoverpa armigera (Ha) SNPV. These two genomes are very similar in their nucleotide (97% identity) and amino acid (99% identity) sequences. The coding regions are much more conserved than the non-coding regions. In HzSNPV/HaSNPV, the 63 open reading frames (ORFs) present in all baculoviruses sequenced so far are much more conserved than other ORFs. HzSNPV has four additional small ORFs compared with HaSNPV, one of these (Hz42) being in a correct transcriptional context. The major differences between HzSNPV and HaSNPV are found in the sequence and organization of the homologous regions (hrs) and the baculovirus repeat ORFs (bro genes). The sequence identity between the HzSNPV and HaSNPV hrs ranges from 90% (hr1) to almost 100% (hr5) and the hrs differ in the presence/absence of one or more type A and/or B repeats. The three HzSNPV bro genes differ significantly from those in HaSNPV and may have been acquired independently in the ancestral past. The sequence data suggest strongly that HzSNPV and HaSNPV are variants of the same virus species, a conclusion that is supported by the physical and biological data.
Supplementary Data from Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers (2023)

&lt;p&gt;Supplementary Table 3&lt;/p&gt;
Method of moment for dielectric scatterers by using block modeling with Galerkin's method (2002)

The scattering characteristics of dielectric bodies are of great interest in many problems, e.g., design of printed antenna on a dielectric substrate and the power absorption by human bodies. The finite difference time domain (FDTD) is a powerful numerical technique and has been applied to many problems including the dielectric bodies. However, the FDTD method cannot be applied to problems including antennas of curved structures such as helical and spiral antennas. The method of moment (MoM) is the most suitable method for such problems. However, for the case including the dielectric material, the integral equation is expressed by a volume integral equation and the CPU time for calculating the mutual impedance between the dielectric blocks could be enormous. Therefore, the point matching technique has been used to reduce the CPU time, but it is difficult to obtain an accurate solution especially when this technique is applied to a problem of antennas near and on the dielectric body. In this paper, the mutual impedance between dielectric blocks for the Galerkin-MoM analysis is expressed as a triple integral form instead of the the double volume integral. Numerical results are shown to demonstrate the accuracy and the short CPU time of the proposed procedure.
Ontology-Based Integration of Streaming and Static Relational Data with Optique (2016)

Real-time processing of data coming from multiple heterogeneous data streams and static databases is a typical task in many industrial scenarios such as diagnostics of large machines. A complex diagnostic task may require a collection of up to hundreds of queries over such data. Although many of these queries retrieve data of the same kind, such as temperature measurements, they access structurally different data sources. In this work we show how Semantic Technologies implemented in our system optique can simplify such complex diagnostics by providing an abstraction layer---ontology---that integrates heterogeneous data. In a nutshell, optique allows complex diagnostic tasks to be expressed with just a few high-level semantic queries. The system can then automatically enrich these queries, translate them into a collection with a large number of low-level data queries, and finally optimise and efficiently execute the collection in a heavily distributed environment. We will demo the benefits of optique on a real world scenario from Siemens.
Synthesis and central dopaminergic activities of (.+-.)-hexahydro-4H-indolo[3,4-gh][1,4]benzoxazine derivatives [(.+-.)-9-oxaergolines] (1983)

The synthesis and biological activities of a series of (+/-)-hexahydro-7H-indolo[3,4-gh][1,4]benzoxazine derivatives [(+/-)-trans-9-oxaergolines] with central dopamine (DA) agonist properties are described. The compounds were prepared from [2aRS-(2a alpha,4 beta,5 alpha)]-4-amino-1,2,2a,3,4, 5-hexahydro-1-(phenylmethyl)benz[cd]indol-5-ol (6b) by alkaline cyclization of the corresponding N-chloracetamide 7b, followed by reduction of the amido group [5aRS-(5a alpha, 6a beta, 10a alpha)]-4,5,5a,6,6a,7,9, 10a-octahydro-4-(phenylmethyl)-7H-indolo[3,4-gh][1,4]benzoxazin-8-one (8b) with LiAlH4. After debenzylation of the resulting amine 9a, the indoline ring of [5aRS-(5a alpha, 6a beta, 10a alpha)]-4,5,5a,6,6a,8,9, 10a-octahydro-7H-indolo[3,4-gh][1,4 ]benzoxazine (10a) was dehydrogenated with MnO2 to give (+/-)-trans-9-oxaergoline (11a), which can be alkylated on the nitrogen (11b,c and 12) and brominated in position 2 (13a,b). The compounds were examined in vitro for their ability to bind to DA receptors and to inhibit prolactin (PRL) secretion in pituitary cells in culture, in vivo both for their DA stimulant effects at the striatal level (circling in 6-OHDA-lesioned animals, DA turnover, and stereotypy) and inhibitory effects on plasma PRL levels in rats, and for their emetic effects in dogs. Most of the tested compounds were active in these tests, and the potency of (+/-)-trans-6-n-propyl-9-oxaergoline (11c) was comparable to that of pergolide mesylate.
Solution and solid-state electronic spectra of low-spin trigonal-bipyramidal complexes containing nickel(II), palladium(II), and platinum(II). Temperature dependence of the lowest energy ligand-field band (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolution and solid-state electronic spectra of low-spin trigonal-bipyramidal complexes containing nickel(II), palladium(II), and platinum(II). Temperature dependence of the lowest energy ligand-field bandJames W. Dawson, Harry B. Gray, James E. Hix Jr., James R. Preer, and L. M. VenanziCite this: J. Am. Chem. Soc. 1972, 94, 9, 2979–2987Publication Date (Print):May 1, 1972Publication History Published online1 May 2002Published inissue 1 May 1972https://pubs.acs.org/doi/10.1021/ja00764a014https://doi.org/10.1021/ja00764a014research-articleACS PublicationsRequest reuse permissionsArticle Views187Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Improving the induction fold of riboregulators for cyanobacteria (2018)

Cyanobacteria are ideal cellular factories for biochemical production because of their ability to fix CO<sub>2</sub> by photosynthesis and convert this molecule into biochemicals. Previously, we engineered a riboregulator that enables post-transcriptional gene regulation in the cyanobacterium Synechocystis sp. PCC 6803. Here, we improved the riboregulator by designing two RNA species, taRNA and crRNA, to enhance its induction fold. We inserted nucleotides into the crRNA loop to enhance intermolecular hybridization and successfully improved its induction fold. The engineered riboregulator exhibited a higher induction fold than the previously engineered riboregulator in both Escherichia coli and Synechocystis sp. PCC 6803. This improved riboregulator can be used to control gene expression over a wide dynamic range in cyanobacteria.