gebhart/patrepeval huggingface dataset:
Data from Evaluation of d-Methionine as a Novel Oral Radiation Protector for Prevention of Mucositis (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Oral mucositis is a common acute morbidity associated with radiation and/or chemotherapy treatment for cancer. d-Methionine (d-Met), the dextro-isomer of the common amino acid l-methionine, has been documented to protect normal tissues from a diverse array of oxidative insults.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; We evaluated if d-Met could selectively prevent radiation-induced oral mucositis using &lt;i&gt;in vitro&lt;/i&gt; cell culture models as well as an &lt;i&gt;in vivo&lt;/i&gt; model of radiation injury to the oral mucosa in C3H mice.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Unlike free-radical scavengers, which protected both normal and transformed tumor cells &lt;i&gt;in vitro&lt;/i&gt; from radiation-induced cell death, treatment with d-Met in culture protected nontransformed primary human cells from radiation-induced cell death (protective factor between 1.2 and 1.6; &lt;i&gt;P&lt;/i&gt; &lt; 0.05) whereas it did not confer a similar protection on transformed tumor cells. d-Met treatment also provided significant protection to normal human fibroblasts, but not to tumor cell lines, from radiation-induced loss of clonogenicity (protection factor, 1.6 ± 0.15). d-Met treatment did not alter DNA damage (as measured by histone phosphorylation) following irradiation but seemed to selectively mitigate the loss of mitochondrial membrane potential in nontransformed cells, whereas it did not provide a similar protection to tumor cells. Tumor control of implanted xenografts treated with radiation or concurrent cisplatin and radiation was not altered by d-Met treatment. Pharmacokinetics following administration of a liquid suspension of d-Met in rats showed 68% bioavailability relative to i.v. administration. Finally, in a murine model of mucositis, a dose-dependent increase in protection was observed with the protective factor increasing from 1.6 to 2.6 over a range of oral d-Met doses between 200 and 500 mg/kg (&lt;i&gt;P&lt;/i&gt; &lt; 0.0003).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt;d-Met protected normal tissues, but not tumor cells, in culture from radiation-induced cell death; it also protected normal cells from radiation-induced mucosal injury in a murine model but did not alter tumor response to therapy. Further studies on the use of d-Met to protect from oral mucositis are warranted.&lt;/p&gt;&lt;/div&gt;
Genetics of obesity and body weight regulation (2000)

Evidence has demonstrated that genetic factors play an important role in determining body weight and fat stores in humans and other mammals. In most cases, genetic variation appears to establish an individual’s predisposition to developing obesity, with environmental and psychological factors contributing significantly to the expression of the obese phenotype. Understanding of the genes that contribute to weight and energy homeostasis continues to advance rapidly. During the past year, a more detailed understanding of the mechanisms underlying monogenic causes of obesity in rodents has developed. Studies with transgenic and knock-out mice have identified several new components of central and peripheral weight and energy regulatory pathways. Rare monogenic causes of obesity in humans have demonstrated conservation of basic mechanisms across species and confirmed the relevance of rodent studies to human disease. The value of animal models has been further extended with the demonstration of mutants in mice, fruitflies, and worms that reveal important interactions between genetic and environmental determinants of energy regulation and feeding behavior. Linkage and association studies in both mice and humans have refined the search for the genes that underlie the more subtle and common forms of human obesity, and those that are responsible for the rare and dramatic obesity syndromes that most frequently arise in children. This paper discusses the most significant of these recent developments.
Molecular regulation of CC-chemokine receptor 3 expression in human T helper 2 cells (2001)

In developing T helper 1 (Th1) and Th2 cells the acquisition of effector function is intimately connected with the acquisition of new migratory capacities, as exemplified by differential expression of chemokine receptors. This study investigates the molecular mechanisms responsible for Th2-restricted expression of the CC-chemokine receptor 3 (CCR3). The minimal promoter in T cells was identified in the -149 base pair (bp) upstream sequence that contains a positive regulatory element. A strong negative element was also localized in the flanking intronic sequence. The study further investigates the role of chromatin remodeling in the regulation of this Th2-specific gene. Drugs that affect the chromatin structure facilitate CCR3 expression in T cells. Furthermore, in differentiating Th2 cells, selected regions are associated with acetylated-H3 histones and become more accessible to DNase I. These results suggest that in Th2 cells both cytokine production and migratory capacity are regulated through a similar mechanism involving chromatin remodeling.
Guest Editorial: Cloud-Edge Computing for Cyber-Physical Systems and Internet of Things (2021)

This Special Section on ‘`Cloud-Edge Computing for Cyber-Physical Systems and Internet-of-Things’' is oriented to the dissemination of a few of those latest research and innovation results, covering many aspects of design, optimization, implementation, and evaluation of emerging cloud-edge solutions for CPS and IoT applications. The selected high-quality contributions cover a broad range of novel technologies and application scenarios in CPS and IoT. We hope that these accepted papers will produce long-lasting impacts, as well as stimulating and encouraging the international community to work on this exciting and impactful topic.
Integrated HPTLC‐based Methodology for the Tracing of Bioactive Compounds in Herbal Extracts Employing Multivariate Chemometrics. A Case Study on Morus alba (2017)

Chemometric tools supported the development of a novel HPTLC-based methodology for the tracing of tyrosinase inhibitors in M. alba extract. All steps of the experimental procedure implemented techniques that afford essential key elements for application in high-throughput screening procedures for drug discovery purposes. Copyright © 2017 John Wiley & Sons, Ltd.
Low-depth amplitude estimation on a trapped-ion quantum computer (2022)

Amplitude estimation (AE) is a fundamental quantum algorithmic primitive that enables quantum computers to achieve quadratic speedups for a large class of statistical estimation problems, including Monte Carlo methods. Recent works have succeeded in somewhat reducing the necessary resources for AE by trading off some of the speedup for lower depth circuits, but high quality qubits are still needed for demonstrating such algorithms. Here, we report the results of an experimental demonstration of AE on a state-of-the-art trapped ion quantum computer. AE was used to estimate the inner product of randomly chosen four-dimensional unit vectors, and the low-depth AE algorithms were based on the maximum likelihood estimation (MLE) and the Chinese remainder theorem (CRT) techniques. Significant improvements in accuracy were observed for the MLE based approach when deeper quantum circuits were taken into account, including circuits with more than 90 two-qubit gates and depth 60, achieving a mean additive estimation error on the order of ${10}^{\ensuremath{-}2}$. The CRT based approach was found to provided accurate estimates for many of the data points but was less robust against noise on average. Last, we analyze two more AE algorithms that take into account the specifics of the hardware noise to further improve the results.
Tracked air-cushion vehicles for ground transportation system (1968)

A general analysis of the forces and power requirements for transportation in a natural atmosphere is presented in the first part. A good picture of this problem can be achieved by drawing plots of stresses against speed. The second part surveys the major characteristics of a transportation service and their relation with the most important technical data concerning vehicle and track. The third part is concerned with the representation of the dynamic response of a tracked air-cushion vehicle (TACV) to excitation from track form's tolerances when the speed is varying. Some experimental results are shown.
Supplementary Figure S2 from Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models (2023)

&lt;p&gt;Cell cycle-dependent effects of ART558 in combination with IR&lt;/p&gt;
Investigation of the Dynamic Behavior of Bridged Nanotube Resonators by Dissipative Particle Dynamics Simulation (2008)

Carbon nanotube (CNT)-based bridged resonators are investigated using a mesoscale dissipative particle dynamics model. Owing to their nanometer size, low mass, and ultrahigh resonance frequency, CNT-based resonators have the potential to become excellent tension, strain, or mass sensors. In this report, the resonance frequency of tubes of different lengths and in different states of tension is extracted from the numerical results and shown to fit with continuum elastic theory. Since in many cases, CNTs are produced slacked rather than taut, the effect of slackness on the resonance frequencies is presented and shown to reduce the sensitivity of the resonator considerably. According to our simulations, temperature has a major effect on the resonance frequencies and should be considered when analyzing bridged resonators. The investigation includes measurements of the vibration amplitude at different temperature, tube length, and strain. The intrinsic quality factor of carbon nanotube resonators is also discussed. Finally, the simulations presented here show that the dissipative particle dynamics model is suited to describe CNT devices such as resonator-based sensors.
RETRACTED: Evaluating the efficacy and safety of a novel prophylactic nasal spray in the prevention of SARS-CoV-2 infection: A multi-centre, double blind, placebo-controlled, randomised trial. (2022)

Background The COVID-19 pandemic continues to devastate communities all over the world. The aim of this study was to evaluate the efficacy and safety of the test agent as a prophylaxis against SARS-CoV-2 infection in a population of high-risk healthcare workers. Methods The study was a multi-centre, prospective, double blind, randomized, placebo-controlled trial. Key eligibility criteria included absence of significant co-morbidity and no previous SARS-CoV-2 infection or vaccination. Participants were randomised to either the active agent nasal spray or placebo using computer generated random number tables. The nasal spray was administered 3 times daily over a 45 day course. The primary end point was the percentage of subjects who tested positive for IgGS (anti-spike, immunoglobulin G specific to the spike protein of SARS-CoV-2) at day 45. Results Between 16th April 2021 and 26th July 2021, 556 participants were analysed for the primary endpoint (275 Test; 281 Placebo). The test agent significantly reduced SARS-CoV-2 infection compared to placebo [36 cases (13.1%) Vs 97 cases (34.5%); OR 0.29 (95% CI; 0.18-0.45), p < 0.0001]. Fewer clinical symptoms were also seen in the test group [57 cases (17.6%) vs 112 cases (34.6%); OR 0.40, (95% CI; 0.27-0.59), p < 0.0001]. No harmful effects were associated with taking the test agent. Conclusion The test agent significantly reduced SARS-CoV-2 infection in healthcare workers, with 62% fewer infections when compared to placebo. It was found to be safe and well tolerated and offers a novel treatment option for prophylaxis against SARS-CoV-2 infection.
Short report on use of medications During pregnancy and lactation (2015)

Pharmacotherapy amid pregnancy may represent a critical danger to the mother and her unborn child. The potential teratogenesis of a few solutions and the physiologic changes which influence drug mien in pregnancy are of awesome concern to clinicians and other wellbeing experts included in the treatment of pregnant ladies.1 Medications are known not for 1% of the conceivable outside an etiological elements of innate deformities
Towards End-to-End Neural Face Authentication in the Wild -- Quantifying and Compensating for Directional Lighting Effects (2021)

The recent availability of low-power neural accelerator hardware, combined with improvements in end-to-end neural facial recognition algorithms provides, enabling technology for on-device facial authentication. The present research work examines the effects of directional lighting on a State-of-Art(SoA) neural face recognizer. A synthetic re-lighting technique is used to augment data samples due to the lack of public data-sets with sufficient directional lighting variations. Top lighting and its variants (top-left, top-right) are found to have minimal effect on accuracy, while bottom-left or bottom-right directional lighting has the most pronounced effects. Following the fine-tuning of network weights, the face recognition model is shown to achieve close to the original Receiver Operating Characteristic curve (ROC)performance across all lighting conditions and demonstrates an ability to generalize beyond the lighting augmentations used in the fine-tuning data-set. This work shows that an SoA neural face recognition model can be tuned to compensate for directional lighting effects, removing the need for a pre-processing step before applying facial recognition.
In Situ Phosphine Oxide Reduction: A Catalytic Appel Reaction (2011)

Several important reactions in organic chemistry thrive on stoichiometric formation of phosphine oxides from phosphines. To avoid the resulting burden of waste and purification, cyclic phosphine oxides were evaluated for new catalytic reactions based on in situ regeneration. First, the ease of silane-mediated reduction of a range of cyclic phosphine oxides was explored. In addition, the compatibility of silanes with electrophilic halogen donors was determined for application in a catalytic Appel reaction based on in situ reduction of dibenzophosphole oxide. Under optimized conditions, alcohols were effectively converted to bromides or chlorides, thereby showing the relevance of new catalyst development and paving the way for broader application of organophosphorus catalysis by in situ reduction protocols.
High capacitance ratio RF MEMS dielectric-less switched capacitor (2013)

This paper presents a novel RF-MEMS dielectric-less switched capacitor that exhibits a high capacitance ratio. The proposed design is based on a floating contact element concept that results in a reduced up state capacitance. The switched capacitor was fabricated on 200 mm silicon wafer with an industrial process developed for manufacturing robust and reliable packaged RF MEMS devices. RF Measurements up to 20 GHz were performed on the fabricated device, showing a capacitance ratio higher than 30:1 with a good quality factor over the operating frequency range. This RF MEMS switched capacitor is suitable for adaptive and reconfigurable RF circuits.
Transport capacity for a catch-up television service (2009)

One of the biggest advantages of interactive television (TV) is that it allows the viewer to watch the content at his or her most convenient time, either by pausing an ongoing broadcast or by selecting to view the content at a time later than the original airing time. The former service, often referred to as Pause Life TV (PLTV), and the latter, often referred to as Catch-Up TV (CUTV), require that an individual unicast flow is set up per user, whereas for the traditional Linear Programming TV (LPTV) the user just tunes in to a multicast flow that can serve many viewers. We first show that when services like PLTV and CUTV gain in popularity, the transport capacity required in certain parts of the network risks to grow unwieldy, unless the content is replicated (i.e., cached) in the appropriate places in the network. Subsequently, we show that a good caching algorithm that tracks the evolving popularity of the content and takes into account the initial popularity, allows keeping the required capacity under control. Finally, we discuss the trade-offs involved in determining the optimal cache location.
Usable trust anchor management (2009)

Security in browsers is based upon users trusting a set of root Certificate Authorities (called Trust Anchors) which they may know little or nothing about. Browser vendors face a difficult challenge to provide an appropriate interface for users. Providing usable Trust Anchor Management (TAM) for users, applications and PKI deployers is a complex task. The PKIX working group at Internet Engineering Task Force (IETF) is working on a new protocol, the Trust Anchor Management Protocol (TAMP), which will provide a standardized method to automatically manage trust anchors in applications and devices. Although promising, this protocol does not go far enough to allow users to gather information about previously unknown trust anchors in an automatic fashion. We have proposed the PKI Resource Query Protocol (PRQP)---which is currently an Internet Draft on Experimental Track with IETF---to provide applications with an automatic discovery system for PKI management. In this paper we describe the basic architecture and capabilities of PRQP that allow Browsers to provide a more complete set of trust anchor management services. We also provide the design of a PRQP enabled infrastructure that uses a trust association mechanism to provide an easy solution for managing Trust Anchors for Virtual Organizations.
Preparation and microwave measurements of stacked Nb/(Al/AiOx/Nb)n superconducting tunnel structures (1993)

The I-V characteristics of stacked Nb/(Al/A1Ox/Nb)n superconducting tunnel structures with n=3 and n=6 were measuredunder microwave irradiation of 45 and 136 GHz. The classical responce of the structures was observed over a wide range ofinput RF power at 45 GHz. Photon-assisted steps in the I-V characteristics were observed at 136 GHz. The widths of the stepscorrespond to the response from only 2 and 4 junctions in 3- and 6-barrier structures, respectively.
Nanocomposites: Nanocomposite Hydrogels as Platform for Cells Growth, Proliferation, and Chemotaxis (Small 35/2016) (2016)

L. De Cola and co-workers report a nanocomposite hydrogel able to induce in vitro chemotaxis of stem cells on page 4881. The cover image shows a nanocomposite hydrogel containing mesoporous silica nanoparticles integrated into the polymeric network. The controlled release of SDF-1α from the hydrogel induced the chemotaxis of stem cells, while the optimal mechanical properties enhanced stem cells proliferation. These attractive properties together with the low inflammatory response in vivo make this hydrogel a promising material for tissue engineering applications.
Imaging of Atomic Layer Deposited (ALD) Tungsten Monolayers on α-TiO2(110) by X-ray Standing Wave Fourier Inversion (2006)

A single atomic layer of tungsten grown by atomic layer deposition (ALD) on a single-crystal rutile TiO2(110) support is studied by the X-ray standing wave (XSW) technique. The surface structural and chemical properties were also examined using atomic force microscopy, X-ray photoelectron spectroscopy, and low-energy electron diffraction. The XSW measured set of hkl Fourier components for the W atomic distribution function are summed together to produce a model-independent 3D map of the W atoms relative to the rutile lattice. The 3D atomic image shows surface tungsten atoms equally occupying the two nonequivalent Ti sites with a slight outward displacement. This corresponds to the atop and bridge sites with respect to the underlying lattice oxygen atoms. These XSW measurements clearly show that ALD conformal layers can be highly coherent with respect to the substrate lattice.
Optical Calibration of SNO+ (2015)

SNO is being upgraded to SNO+, which has as its main goal the search for neutrinoless double-beta decay. The upgrade is defined by filling with a novel scintillator mixture containing 130Te. With a lower energy threshold than SNO, SNO+ will be sensitive to other exciting new physics. Here we are describing new optical calibration system that meets new, more stringent radiopurity requirements has been developed.
16. PAIN MANAGEMENT AFTER ARTHROSCOPIC ROTATOR CUFF REPAIR: PROSPECTIVE RANDOMISED STUDY OF 140 CASES COMPARING THREE ANTI-PAIN TECHNIQUES (2011)

Purpose of the study: Arthroscopic repair of rotator cuff tears is a painful technique. We conducted a randomized controlled trial to analyze prospectively the level of postoperative pain after this procedure and to assess the efficacy of three anti-pain techniques. Material and method: This prospective randomized study included 140 patients attending two centres specialized in shoulder surgery who underwent arthroscopic rotator cuff repair from January to November 2008. Preoperatively, patients were assigned to three anti-pain techniques: interscalenic catheter (KTIS) (n=44 patients), subacromial catheter (KTSA) (n=64 patients), unique subacromial injection of 2% ropivacaine (INJ) (n=32 patients). The procedure was performed under general anaesthesia in all cases. Criteria used to evaluate the efficacy of the anti-pain techniques were: pain as assessed by a visual analogue scale (VAS) the day before operation to the 30th postoperative day; daily consumption and total dose of opiates; subjective satisfaction with pain management assessed on day 30. Results: The pain profile was the same as demonstrated last year with a painful displacement on day 1 and progressive decline in pain through day 30 when the pain level was lower than preoperatively. Two risk factors were noted: isolated distal tears of the supraspinatus and concomitant acromioplasty. On day 0, the VAS was ≤ 1.7 in the KTIS group versus 3.6 and 3.5 respectively in the KTSA and INJ groups (p Conclusion: The interscalenic catheter technique is more effective than the two other techniques. The subacromial catheter is not better than a single injection of local anaesthetic and is associated with greater risk, suggesting its use should be revisited.
A Point Mutation in the SH2 Domain of Bruton's Tyrosine Kinase in Atypical X-Linked Agammaglobulinemia (1994)

X-Linked Agammaglobulinemia is the prototypical humoral immunodeficiency first described by Bruton in 19521. It is characterized by a paucity of circulating B cells and a drastic reduction in the serum concentrations of immunoglobulins2,3. Studies analyzing patterns of X chromosome inactivation showed that the genetic defect was intrinsic to the B-cell lineage,4 and mapping studies located the defect in the midportion of the long arm of the X chromosome at Xq225–7. Recently, two reports demonstrated that mutations of the cytoplasmic tyrosine kinase gene Btk (the gene for Bruton's tyrosine kinase, previously designated bpk or atk) are . . .