gebhart/patrepeval huggingface dataset:
Analyser le travail politique (2014)

Les activités politiques sont diffuses et protéiformes, puisqu’y contribuent aussi bien le conseiller général qui prend la parole au cours d’une assemblée départementale, le maire qui participe à la fête de son village, le conseiller ministériel qui reçoit les représentants d’un groupe d’intérêt, l’assistant parlementaire qui répond au courrier reçu par son député, le citoyen qui exprime son opinion à travers un bulletin de vote, etc. Que l’on considère les acteurs qui s’y livrent, les pratiques qui y sont déployées, les interactions qui y prennent forme, les institutions qui y sont engagées, les significations qui y sont produites, les savoirs qui y sont mobilisés, ces activités sont extrêmement hétérogènes. D’un certain point de vue chacune des activités prises en exemple alimente la même sphère d’action et participe au fonctionnement d’un même système – politique. Mais elles y contribuent de manière différenciée au point qu’elles ne sont pas des activités strictement comparables. Analyser les activités politiques en tant que travail suppose de se doter de catégories de pensée permettant de prendre simultanément en compte les éléments communs partagés avec tout travail, et les spécificités découlant de ses qualités de politique.
Kinetic analysis of thyroid hormone action on glucose metabolism in man (1995)

Thyroid hormone action on insulin's effect on glucose kinetics was investigated with the use of a physiological three compartment model. In six healthy volunteers before and after 14 days of thyroxine treatment (300 micrograms/day), a bolus of [3-H3]glucose was injected and the time course of plasma radioactivity was followed closely for 150 min. Then a hyperinsulinemic (1 mU.min-1.kg-1) and euglycemic clamp was started, and euglycemia was maintained for another 250 min. A second bolus of the tracer was then given at 240 min, and the plasma radioactivity was followed for 160 min. Insulin stimulated basal plasma glucose clearance fourfold (p < 0.001) and completely suppressed basal hepatic glucose production (p < 0.001). Concomitantly, the total distribution volume of glucose was increased by 19% (p < 0.05); this change was accompanied by about 50% expansion of the slowly exchanging glucose pool (putatively representing the insulin-dependent compartment). Thyroxine treatment increased plasma triiodothyronine by about 20% (0.1 > p > 0.05) but did not affect basal glucose turnover, insulin-stimulated plasma glucose clearance or the insulin-induced suppression of endogenous glucose output. However, thyroxine treatment blunted the insulin-induced increases in total distribution volume and the slowly exchanging pool of glucose (p = NS vs the basal state). We conclude that minor changes in plasma triiodothyronine (such as occur during overfeeding) do not interfere with the ability of insulin to stimulate the rate of disappearance of glucose or suppress endogenous glucose release; however, our data suggest that they induce finer changes in glucose kinetics, possibly reflecting acceleration or intracellular glucose degradation.
ChemInform Abstract: Synthesis and Antiviral Activities of N‐9‐Oxypurine 1,3‐Dioxolane and 1,3‐Oxathiolane Nucleosides. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Catalytically solid-phase self-organization of nanoporous SnS with optical depolarizability (2016)

The catalytic solid-phase synthesis of self-organized nanoporous tin sulfide (SnS) with enhanced absorption, manipulative transmittance and depolarization features is demonstrated. Using an ultralow radio-frequency (RF) sputtering power, the variation of the orientation angle between the anodized aluminum oxide (AAO) membrane and the axis of the sputtered ion beam detunes the catalytically synthesized SnS from nanorod to nanoporous morphology, along the sidewall of the AAO membrane. The ultraslow catalytic sputtering synthesis on the AAO at the RF plasma power of 20 W and the orientation angle of 0° regulates the porosity and integrality of nanoporous SnS, with average pore diameter of 80-150 nm. When transferring from planar to nanoporous structure, the phase composition changes from SnS to SnS2-Sn2S3, and the optical bandgap shrinks from 1.43 to 1.16 eV, due to the preferred crystalline orientation, which also contributes to an ultralow reflectance of <1% at 200-500 nm when both the transmittance and the surface scattering remain at their maxima. The absorption coefficient is enhanced by nearly one order of magnitude with its minimum of >5 × 10(4) cm(-1) at the wavelength between 200 and 700 nm, due to the red-shifting of the absorption spectrum to at least 100 nm. The catalytically self-organized nanoporous SnS causes strong haze and beam divergence of 20°-30° by depolarized nonlinear scattering at the surface, which favors the solar energy conversion with reduced surface reflection and enhanced photon scattering under preserved transmittance.
Contrasted Patterns of Crossover and Non-crossover at Arabidopsis thaliana Meiotic Recombination Hotspots (2013)

The vast majority of meiotic recombination events (crossovers (COs) and non-crossovers (NCOs)) cluster in narrow hotspots surrounded by large regions devoid of recombinational activity. Here, using a new molecular approach in plants, called "pollen-typing", we detected and characterized hundreds of CO and NCO molecules in two different hotspot regions in Arabidopsis thaliana. This analysis revealed that COs are concentrated in regions of a few kilobases where their rates reach up to 50 times the genome average. The hotspots themselves tend to cluster in regions less than 8 kilobases in size with overlapping CO distribution. Non-crossover (NCO) events also occurred in the two hotspots but at very different levels (local CO/NCO ratios of 1/1 and 30/1) and their track lengths were quite small (a few hundred base pairs). We also showed that the ZMM protein MSH4 plays a role in CO formation and somewhat unexpectedly we also found that it is involved in the generation of NCOs but with a different level of effect. Finally, factors acting in cis and in trans appear to shape the rate and distribution of COs at meiotic recombination hotspots.
Subunit Association and Conformational Flexibility in the Head Subdomain of Human CD81 Large Extracellular Loop (2002)

The large extracellular loop of human CD81, a tetraspanin mediating hepatitis C virus envelope protein E2 binding to human cells, has been crystallized in a hexagonal form. The three-dimensional structure, solved and refined at 2.6 A resolution (R-factor = 22.8%), shows that the protein adopts a dimeric assembly, based on an association interface built up by tetraspanin-conserved residues. Structural comparisons with the tertiary structure of human CD81 large extracellular loop, previously determined in a different crystal form, show marked conformational fluctuations in the molecular regions thought to be involved in binding to the viral protein, suggesting rules for recognition and assembly within the tetraspan web.
Overlay similarity: a new overlay index for metrology tool and scanner overlay fingerprint methodology (2009)

For different CD metrologies like average CD from CD SEM and optical CD (OCD) from scatterometry, CD point-to-point R<sup>2</sup> has been well adopted as the CD correlation index. For different overlay metrologies like image-based box-in-box overlay and scatterometry-based overlay, we propose the cosine similarity as the correlation index of overlay. The cosine similarity is a measure of similarity between two vectors of n dimensions by finding the cosine of the angle between them, often used to compare documents in text mining. It has been widely used in web and document search engines and can be used as the similarity index of overlay tool-to-tool matching and scanner tool-to-tool or day-to-day fingerprint. In this paper, we demonstrate that the cosine similarity has a very high sensitivity to the overly tool performance. We compared the similarities of three generations (A<sub>1</sub>, A<sub>2</sub>, A<sub>3</sub>) of the overlay tools of venders A and B and found that after target re-training and TIS correction on each tool A<sub>1</sub> similarity to A<sub>3</sub> can be improved from 0.9837 to 0.9951. Overlay point-to-point matching with A<sub>3</sub> vs. A<sub>1</sub> can be reduced from 4.8 to 2.1 nm. The tool precision similarities, i.e. tool self best similarity, for A<sub>1</sub>, A<sub>2</sub>, A<sub>3</sub> and B are 0.9986, 0.9990, 0.9995, and 0.9994 respectively. From this table, we demonstrate that we can use old-generation overlay tool with suitable hardware maintenance, to match to the latest-generation overlay tool.
Torque Ripple Minimization in Six-Step PMSM Drives via Variable and Fast DC Bus Dynamics (2019)

Six-step modulated drive systems have been shown to have higher power density and lower switching loss than pulsewidth modulation drive systems. It has also been shown that by manipulating the dc bus voltage, six-step mode can drive permanent magnet synchronous machines (PMSMs) over a wide speed range, and maintain the machine operating point on the maximum torque per ampere curve below the base speed to reduce the machine copper loss. However, high torque ripple exists while in this type of six-step mode. This paper develops the control design methodologies to leverage the variable and fast dc bus manipulation, provided by two-step finite-settling-step dc-to-dc converter control, to minimize torque ripple in six-step PMSM drives. Two torque control algorithms: existing voltage angle based torque control and deadbeat-direct torque and flux control are used to evaluate torque ripple reduction capability and energy savings potential of six-step PMSM drive systems.
Performance Analysis of FDD Massive MIMO Systems Under Channel Aging (2017)

In this paper, we study the effect of channel aging on the uplink and downlink performance of an FDD massive MIMO system, as the system dimension increases. Since the training duration scales linearly with the number of transmit dimensions, channel estimates become increasingly outdated in the communication phase, leading to performance degradation. To quantify this degradation, we first derive bounds on the mean squared channel estimation error. We use the bounds to derive deterministic equivalents of the receive SINRs, which yields a lower bound on the achievable uplink and downlink spectral efficiencies. For the uplink, we consider maximal ratio combining and MMSE detectors, while for the downlink, we consider matched filter and regularized zero forcing precoders. We show that the effect of channel aging can be mitigated by optimally choosing the frame duration. It is found that using all the base station antennas can lead to negligibly small achievable rates in high user mobility scenarios. Finally, numerical results are presented to validate the accuracy of our expressions and illustrate the dependence of the performance on the system dimension and channel aging parameters.
Abstract 5784: Overcoming FFPE hurdles to enable high quality hybrid capture libraries and somatic mutation detection in matched tumor-normal patient samples (2022)

Abstract In cancer genomics, a common source of DNA is formalin-fixed, paraffin-embedded (FFPE) tissue from patient surgical samples, where in most cases high quality fresh or frozen tissue samples are not available. FFPE DNA poses many notable challenges for preparing NGS libraries, including low input amounts and highly variable damage from fixation, storage, and extraction methods. Due to the high cost of sequencing and variability of coverage, regions of interest are often specifically enriched using hybrid capture-based approaches, but these methods require a high input of diverse, uniform DNA library to achieve the coverage required for somatic mutation identification in tumor samples.We applied a multi-faceted approach to improving the yield, quality, and coverage from libraries generated from cancer patient sample sets. Using tumor-normal pairs, we evaluated the impact of our method on the sensitivity and accuracy of somatic variant detection. Matched frozen tissue provided a truth set of somatic variants for a particular tumor as well as a gold standard by which we could assess the quality of our FFPE hybrid capture libraries. Combining DNA damage repair and a novel enzymatic fragmentation mix upstream of library preparation not only reduced the false positive rate in somatic variant detection by repairing damage-derived mutations but also improved the library yield, complexity, coverage uniformity, and hybrid capture library quality metrics. The use of unique molecular identifier (UMI)-containing adaptors ensured accurate duplicate marking. Finally, a new PCR master mix boosts the library yield without compromising library quality in FFPE samples ranging from very poor quality to high quality. This combinatorial approach allows even the poorest quality FFPE samples to achieve high quality libraries with sufficient input for hybrid capture in our study. Citation Format: Margaret R. Heider, Jian Sun, Brittany S. Sexton, Bradley W. Langhorst, Andrew Gray, Lauren Higgins, Lixin Chen, Lynne Apone, Thomas C. Evans, Nicole M. Nichols, Eileen T. Dimalanta, Theodore B. Davis, Pingfang Liu. Overcoming FFPE hurdles to enable high quality hybrid capture libraries and somatic mutation detection in matched tumor-normal patient samples [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5784.
Filter, Rank, and Transfer the Knowledge: Learning to Chat (2010)

Learning to chat is a fascinating machine learning task with many applications from user-modeling to artificial intelligence. However, most of the work to date relies on designing large hard-wired sets of rules. On the other hand, the growth of social networks on the web provides large quantities of conversational data, suggesting that the time is ripe to train chatbots in a more data driven way. A first step is to learn to chat by ranking the response repository to provide responses that are consistent with the user’s expectations. Here we use a three phase ranking approach for predicting suitable responses to a query in a conversation. Sentences are first filtered, then efficiently ranked, and then more precisely re-ranked in order to select the most suitable response. The filtering is done using part-of-speech tagging, hierarchical clustering, and entropy analysis methods. The first phase ranking is performed by generating a large set of high-level grammatical and conceptual features, exploiting dictionaries and similarity measurement resources such as wikipedia similarity graphs, and by ranking using a boosted regression tree (MART) classifier. The more precise (conceptual) ranking is performed by designing more conceptual features obtained from similarity measurement resources such as query refinement and suggestion systems, sentence paraphrasing techniques, LDA topic modeling and structural clustering, and entropy analysis over wikipedia similarity graphs. The sentences are then ranked according to the confidence of a Transfer AdaBoost classifier, trained using transfer-learning methods in which a classification over a large corpus of noisy twitter and live-journal data is considered as the source domain, and the collaborative ranking of actively collected conversations, which are labeled in an online framework using user feedback, is considered as the destination domain. We give results on the performance of each step, and on the accuracy of our three phase ranking framework.
Data from Stress Chaperone Mortalin Contributes to Epithelial-to-Mesenchymal Transition and Cancer Metastasis (2023)

&lt;div&gt;Abstract&lt;p&gt;Mortalin/mthsp70 (HSPA9) is a stress chaperone enriched in many cancers that has been implicated in carcinogenesis by promoting cell proliferation and survival. In this study, we examined the clinical relevance of mortalin upregulation in carcinogenesis. Consistent with high mortalin expression in various human tumors and cell lines, we found that mortalin overexpression increased the migration and invasiveness of breast cancer cells. Expression analyses revealed that proteins involved in focal adhesion, PI3K–Akt, and JAK–STAT signaling, all known to play key roles in cell migration and epithelial-to-mesenchymal transition (EMT), were upregulated in mortalin-expressing cancer cells. We further determined that expression levels of the mesenchymal markers vimentin (VIM), fibronectin (FN1), β-catenin (CTNNB1), CK14 (KRT14), and hnRNP-K were also increased upon mortalin overexpression, whereas the epithelial markers E-cadherin (CDH1), CK8 (KRT8), and CK18 (KRT18) were downregulated. Furthermore, shRNA-mediated and pharmacologic inhibition of mortalin suppressed the migration and invasive capacity of cancer cells and was associated with a diminished EMT gene signature. Taken together, these findings support a role for mortalin in the induction of EMT, prompting further investigation of its therapeutic value in metastatic disease models. &lt;i&gt;Cancer Res; 76(9); 2754–65. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Continuousness of interactions between hydrogen and plastic deformation of ultra-high strength steel sheet consisting of ferrite and nanometer-sized precipitates (2022)

The continuousness of the interactions between hydrogen and plastic deformation of an ultra-high strength steel sheet consisting of ferrite and nanometer-sized precipitates has been investigated by tensile tests after or during cathodic hydrogen charging. In the tensile test in the air after hydrogen pre-charging, a hydrogen thermal desorption analysis shows that the amount of hydrogen desorbed decreases with increasing applied tensile strain from room temperature to 50 °C, but increases in the high temperature region. Upon tensile straining to 0.06, no hydrogen is desorbed in the low temperature region, and the change in desorption behaviour when strain exceeds 0.06 is negligible. This suggests that substantial interactions between hydrogen and plastic deformation in the test with hydrogen pre-charging occur only in the early stages of deformation. In contrast, in the tensile test during hydrogen charging, the hydrogen desorption which begins from room temperature continues even upon tensile straining to 0.06, suggesting continuous interactions, and a unique dislocation structure resembling sub-grain boundaries is observed. Upon aging at room temperature after tensile straining to 0.06 during hydrogen charging, all hydrogen desorption lower than 100 °C shifts to the high temperature region, but the recovery of elongation is not necessarily complete. When tensile strain is applied during hydrogen charging, continuous interactions presumably induce anomalous damage, thereby enhancing the degradation of ductility. The results of the present study strongly support the conclusion that the continuousness of the dynamic interactions between hydrogen and plastic deformation plays essential roles in hydrogen embrittlement of ferritic steel.
Determination of Hysteresis Loss by Drag Force Measurements with Cancelled Normal Field Components (2006)

Drag force measurements on 7 of 10 strip samples of varying composition, thickness and coercivity, correlated closely with hysteresis loss measurements made by conventional methods was studied.
Processing by CD26/dipeptidyl‐peptidase IV reduces the chemotactic and anti‐HIV‐1 activity of stromal‐cell‐derived factor‐1α (1998)

The chemokine stromal-cell-derived factor-1alpha (SDF-1alpha) chemoattracts lymphocytes and CD34+ haematopoietic progenitors and is the ligand for CXCR4 (CXC chemokine receptor 4), the main co-receptor for T-tropic HIV-1 strains. SDF-1alpha was NH2-terminally cleaved to SDF-1alpha(3-68) by dipeptidyl-peptidase IV (CD26/DPP IV), which is present in blood in soluble and membrane-bound form. SDF-1alpha(3-68) lost both lymphocyte chemotactic and CXCR4-signaling properties. However, SDF-1alpha(3-68) still desensitized the SDF-1alpha(1-68)-induced Ca2+ response. In contrast to CD26/DPP IV-processed RANTES(3-68), SDF-1alpha(3-68) had diminished potency to inhibit HIV-1 infection. Thus, CD26/DPP IV impairs the inflammatory and haematopoietic potency of chemokines but plays a dual role in AIDS.
Limited nerve impulse blockade by "leashed" local anesthetics (1987)

To measure the depth of the local anesthetic binding site within the neuronal membrane, biotin-containing polyethylene glycols having zero, three, and six ethylene glycol subunits were added to the p-amino termini of tetracaine and procaine, thereby interposing a pharmacologically inert "spacer" molecule between the local anesthetic and the biotin moiety. These biotinyl-local anesthetic derivatives produced "tonic" inhibition of the compound action potential of split, desheathed frog sciatic nerves in a concentration-dependent, reversible manner. However, no inhibition of the action potential occurred when sufficient avidin, a 66,000-MW protein that binds four biotins, was present to bind and anchor the biotin-containing end of each derivative outside the plasma membrane. Increasing the "leashed" anesthetic derivative's concentration to 4 times that which reduced impulse height by 50% in the absence of avidin still produced no detectable block when equimolar avidin was present. Apparently, the "spacer" in the derivative compound was too short to permit the avidin-complexed anesthetic to reach its site of action on the sodium channel. In a similar fashion, the local anesthetic derivatives produced "use-dependent" block when drug-treated nerves were stimulated at 40 Hz in the absence of equimolar avidin, but failed to produce "use-dependent" block when equimolar avidin was present. In common with others, we assume that tertiary amine local anesthetics may reach their binding site via hydrophobic (transmembrane) pathways without necessarily entering the cytoplasm. Thus, since our longest local anesthetic derivative, that containing six ethylene glycol subunits, placed the local anesthetic group a maximum of 15-18 A from the surface of the avidin moiety, we conclude that the local anesthetic binding site for block of sodium channels of amphibian nerve must be greater than or equal to 15 A from the outer surface of the plasma membrane.
A molecular MRI probe to detect treatment of cardiac apoptosis in vivo (2011)

Cell death by apoptosis is critical in myocardial diseases, and noninvasive detection of early, reversible apoptosis might be useful clinically. Exogenous Annexin-V (ANX) protein binds membrane phosphatidylserine, which is externalized in early apoptosis. A molecular MRI probe was constructed with superparamagnetic iron oxide (SPIO) conjugated to recombinant human ANX (ANX-SPIO). Apoptosis was induced with doxorubicin, a cardiotoxic cancer drug, in culture in neonatal rat ventricular myocytes, cardiac fibroblasts, and mesenchymal stem cells, and in vivo in the mouse heart. ANX-SPIO was validated using T2*-weighted 3T MRI. ANX-SPIO produced T2* signal loss, reflecting iron content, that correlated highly with independent apoptosis markers; bound with high affinity to apoptotic myocytes by competition assay (Ki 69 nM); detected apoptosis in culture much earlier than did TUNEL stain; and revealed fibroblast resistance to apoptosis. With apoptosis in vivo, ANX-SPIO produced diffuse myocardial T2* signal loss that correlated with increased iron stain and caspase activity. Treatment with an alpha-1-adrenergic agonist in vivo reversed apoptosis and eliminated the ANX-SPIO MRI signal. It is concluded that cardiac MRI of ANX-SPIO detects early, nonischemic cardiac apoptosis in culture and in vivo, and can identify reversibly injured cardiac cells in diseased hearts, when treatment is still possible.