gebhart/patrepeval huggingface dataset:
Efficient Room-Temperature Operation of a Quantum Dot Spin-Polarized Light-Emitting Diode under High-Bias Conditions (2023)

Spin-polarized light-emitting diodes (spin LEDs) are essential for the optical transfer of carrier-spin information in spin-based electronic circuits. Efficient operation under high-bias conditions is required for high-speed transfer of spin information and strong light emission. However, achieving high-electroluminescence (EL) circular polarization is hampered by electric-field-induced spin relaxation during drift transport in undoped $\mathrm{Ga}\mathrm{As}$ barriers. Herein, we demonstrate the efficient room-temperature operation of a spin LED using ($\mathrm{In},\mathrm{Ga})\mathrm{As}$ quantum dots (QDs) tunnel coupled with a 5-nm-thick $\mathrm{Ga}(\mathrm{N},\mathrm{As})$ quantum well (QW). A high-EL circular polarization of approximately 7% is achieved, even under high-bias conditions, in comparison with the lower value of approximately 3% for the conventional QD spin LED without $\mathrm{Ga}(\mathrm{N},\mathrm{As})$. This is realized by an increase of spin polarization after injection into the QDs by utilizing remote spin filtering of QD electrons via an adjacent tunnel-coupled $\mathrm{Ga}(\mathrm{N},\mathrm{As})$ QW. These results demonstrate that the tunnel-coupled structure of ($\mathrm{In},\mathrm{Ga})\mathrm{As}$ QDs and $\mathrm{Ga}(\mathrm{N},\mathrm{As})$ QW is a promising active layer of spin LEDs for achieving both strong EL emission and high-EL circular polarization at room temperature.
Effects of meat bone meal as fertilizer on yield and quality of sugar beet and carrot (2015)

Meat and bone meal (MBM) is a by-product of the meat industry and is an important pathway for recycling of N and P. MBM contains about 8% N, 5% P, 1% K and 10% Ca. Field trials compared the effects of MBM and mineral fertilizer on yield and quality of sugar beet (2008-2009) and carrot (2010-2011) in Finland. MBM fertilisation of sugar beet grown on clay loam and sandy clay soil gave 11.4% (2008) and 19.6% (2009) lower yields than mineral fertilizers. The lower root yield in 2008 was compensated by higher extractable sugar content and lower amino-N, K and Na in root but no such compensation in root quality was detected for 2009. Mixing MBM with mineral NPK fertilizers had similar effects as MBM-alone. MBM (80 kg N ha-1 2010 and 60 kg N ha-1 2011) together with K fertilizer (Patentkali®, 180 kg K ha-1) were applied for carrot to a fine sandy till soil in 2010 and sandy loam in 2011. MBM alone gave 14% lower total and marketable root yield than mineral fertilization. The lower yield was compensated by improved quality, lower NO3- content in the carrot and good storability. Adding extra fertilizer during growth or separating fertilization applications had no effect on root yield or quality. MBM performed in these cases mainly as an organic N fertilizer. The N supply from MBM is not sufficient for achieving same yields as with mineral fertilizers. The relative N efficiency of total N of MBM was 83% that of mineral fertilizers. MBM should be targeted on soils with low P status.We conclude that MBM is a reasonably competitive alternative to mineral fertilizers, and as a recycled fertilizer it is a good option for organic production.
Total synthesis of the thiopeptide amythiamicin DElectronic supplementary information (ESI) available: Spectroscopic data for synthetic 1. See http://www.rsc.org/suppdata/cc/b4/b401580k/ (2004)

The first total synthesis of the thiopeptide antibiotic amythiamicin D is described.
Shaped Supercontinuum for Precision Frequency Transfer (2022)

SummaryWe optimize a supercontinuum spectrum for high power at three clock wavelengths, a C-band reference, and an f-2f pair by phase shaping with a chirped fiber Bragg grating. We generate about 100 nW per comb line, with fractional frequency instability of about 10<sup>&#x2212;17</sup> at 1 s, sufficient for frequency comparisons of most optical clocks.
LighterBody: RNN based Anticipated Virtual Body Makes You Feel Lighter (2021)

The virtual body representation had shown the potential of intervention into the sense of body. To investigate how the temporal shift of body representation affects the user's kinetic sensation, we developed a system to anticipate body movement with RNN. We then conducted a user study to assess the effect with the anticipated body movement and the system baseline. Results revealed that the transition from the baseline to the anticipated body induced a lighter bodyweight feeling, and the opposite transition induced a heavier feeling. Our work enlightens the potential of interactive manipulation of the full-body kinetic sensation using virtual body representation.
Bioprocessing Separations Consortium Three-Year Overview: Technical Advances Process Economics Influence, and State of the Science (2020)

The Bioprocessing Separations Consortium solves separations challenges that are unique to bioprocessing. To do this, the Consortium uses two methods: applying existing technologies to new challenges and developing new technologies that may address these unique challenges better than today’s commercial technologies. In its research and development, the Consortium leverages its three core capabilities: materials development and evaluation, process development, and analysis and computation. In its first three years, from 2016 to 2019, the Consortium addressed four critical challenges in biochemical and thermochemical processing. First, the Consortium targeted the fractionation of lignin to enable valorization of this portion of biomass that offers diverse, complex, and valuable building blocks and products. Second, Consortium researchers developed technologies to enable process intensification, which can reduce equipment needs, energy consumption, and waste generation, thereby cutting bioprocessing capital costs and rendering processes more efficient. Third, the Consortium sought to recover carbon from dilute aqueous streams that are common to bioprocessing; recovering dilute carbon can improve process efficiency and economics. Finally, Consortium researchers designed and developed new materials and catalysts to reduce targeted foulants and poisons in bioprocessing streams that can limit the lifetime of downstream catalysts or fermenting microorganisms. Table 1 lists the technologies that were examined and places them in the context of the Consortium’s capabilities, types of bioprocesses, and critical challenges in bioprocessing separations. Overall, across these projects, we have developed separations technologies for 10 bioprocesses, addressed 9 target compounds in bioprocessing, developed 10 materials, and evaluated 4 processes for cost and sustainability.
CXCR7 mediates SDF1‐induced melanocyte migration (2012)

Melanoblasts are derived from the neural crest and migrate to the dermal/epidermal border of skin and hair bulges. Although melanoblast migration during embryogenesis has been well investigated, there are only a few reports regarding the migration of mature melanocytes. Here, we demonstrate that a chemokine, stromal-derived factor-1 (SDF1, also known as CXCL12), and one of its receptor CXCR7 regulate normal human epidermal melanocyte (NHEM) migration. We found that SDF1 induces the directional migration of NHEMs. Interestingly, although both CXCR4 and CXCR7 are expressed in NHEMs, blockade of CXCR4 using a CXCR4-specific neutralizing antibody did not exert any influence on the SDF1-induced migration of NHEMs, whereas blockade of CXCR7 using a CXCR7-specific neutralizing antibody did influence migration. Furthermore, SDF1-induced NHEMs migration exhibited the early hallmark events of CXCR7 signaling associated with MAP kinase activation. It is known that the phosphorylation of ERK through CXCR7 signaling is mediated by β-arrestins. The treatment of NHEMs with SDF1 resulted in the phosphorylation of ERK in a β-arrestin 2-dependent manner. These results suggest that melanocytes may have a unique mechanism of migration via SDF1/CXCR7 signaling that is different from that of other cell types.
Parameterized basis functions for numerically stable behavioral modeling of RF power amplifiers (2014)

In this paper, we propose a new set of parameterized basis functions suitable for behavioral modeling of RF power amplifiers exhibiting memory effects. Depending on the input signal distribution, the proposed basis functions can be optimized for numerically stable model identification procedure. The efficiency and robustness of the resulting polynomial model are demonstrated and compared to the ones of previously published polynomial models. The obtained results revealed an exceptional numerical stability regardless of the input signal statistics, making the proposed new model suitable for multimode and broadband nonlinear wireless transmitters.
Brain failure (1997)

Brain failure or encephalopathy is common in the critically ill and often occurs early in the disease process. Cerebral dysfunction can usually be reversed by promptly treating the underlying cause. Early recognition of brain failure may facilitate prompt treatment, with possible reduction in the incidence of multiple-organ failure and improved survival.
Revival of Right Thoracotomy to Approach Atrio-ventricular Valves in Reoperations (1984)

A right thoracotomy was used to approach the atrio-ventricular (AV) valves in 8 patients who had previously undergone a cardiac operation through a midline sternotomy. Due to an extremely enlarged right heart, to a dilated ascending aorta, or to the presence of anteriorly placed aorto-coronary bypass-grafts, a repeated midline sternotomy was considered to involve the risk of massive hemorrhage in this group of patients. Cardiopulmonary bypass was instituted after cannulation of the right femoral artery and of the right atrium or venae cavae. The ascending aorta was controlled when deemed necessary. Since minimal dissection was required and the exposure of the AV valves was excellent, the operative procedure was uneventfully and expeditiously carried out in all cases. A right thoracotomy provides a convenient way to approach the AV valves in selected patients who have had previous heart surgery through a midline sternotomy.
Tuneable electron-beam-driven nanoscale light source (2010)

Recently demonstrated 'light-wells' - free-electron-driven tuneable nanoscale light sources - generate optical photons as electrons travel down a nano-hole through a metal-dielectric multilayer structure. We report here on the application of boundary element modeling methods to the simulation of light-well output characteristics. The model is found to successfully reproduce the key features observed in experiment and as such will aid in the development and optimization of future device structures.
Antimicrobial Resistance in Wildlife in Guadeloupe (French West Indies): Distribution of a Single blaCTX–M–1/IncI1/ST3 Plasmid Among Humans and Wild Animals (2020)

Limited data are available on the contribution of wildlife to the spread of antibacterial resistance. We determined the prevalence of resistance to antibiotics in <i>Escherichia coli</i> isolates collected from wild animals in 2013 and 2014 and the genetic basis for resistance to third-generation cephalosporin in Guadeloupe. We recovered 52 antibiotic-resistant (AR) <i>E. coli</i> strains from 48 of the 884 (5.4%) wild animals tested (46 iguanas, 181 birds, 289 anoles, and 368 rodents at 163 sampling sites). Rodents had higher rates of carriage (<i>n</i> = 38, 10.3%) than reptiles and birds (2.4% and 1.1%, respectively, <i>p</i> < 0.001). A significant association (<i>p</i> < 0.001) was found between the degree of anthropization and the frequency of AR <i>E. coli</i> carriage for all species. The carriage rate of ciprofloxacin- and cefotaxime-resistant isolates was 0.7% (6/884) and 1.5% (13/884), respectively. Most (65.4%) AR <i>E. coli</i> were multi-drug resistant, and the prevalence of extended-spectrum beta-lactamase (ESBL)-producing <i>E. coli</i> was low (<i>n</i> = 7, 0.8%) in all species. Eight ESBL-producing <i>E. coli</i> were recovered, two genetically unrelated isolates being found in one bird. These isolates and 20 human invasive ESBL <i>E. coli</i> isolates collected in Guadeloupe during the same period were investigated by whole genome sequencing. <i>bla</i> <sub>CTX-M-1</sub> was the only ESBL gene shared by three animal classes (humans, <i>n</i> = 2; birds, <i>n</i> = 2; rodents, <i>n</i> = 2). The <i>bla</i> <sub>CTX-M-1</sub> gene and most of the antimicrobial resistance genes were present in a large conjugative IncI1 plasmid that was highly similar (>99% nucleotide identity) to ESBL-carrying plasmids found in several countries in Europe and in Australia. Although the prevalence of ESBL-producing <i>E. coli</i> isolates was very low in wild animals, it is of concern that the well-conserved IncI1 plasmid-carrying <i>bla</i> <sub>CTX-M-1</sub> is widespread and occurs in various <i>E. coli</i> strains from animals and humans.
Analysing the impact of market variations in the steel industry: A simulation approach (2008)

International audience
Akt-Dependent and Isoform-Specific Regulation of Dopamine Transporter Cell Surface Expression (2010)

Dopamine (DA) is a neurotransmitter implicated in multiple functions, including movement, cognition, motivation, and reward. The DA transporter (DAT) is responsible for clearing extracellular DA, thereby terminating DA neurotransmission. Previously, it has been shown that insulin signaling through protein kinase B/Akt regulates DAT function by fine-tuning DAT cell surface expression. Importantly, specific Akt isoforms (e.g., Akt1, Akt2) serve distinct physiological functions. Here, we demonstrate using isoform-specific Akt inhibitors that basal activity of Akt2, rather than Akt1, regulates DAT cell surface expression. Since Akt2 activation is mediated by insulin, these data further implicate insulin signaling as an important modulator of DAT function and dopaminergic tone.
Temperature dependence of the exciton transition in semiconductor quantum dots (2006)

The authors measure the temperature dependence of the first absorption feature (dE∕dT) for different sizes of CdSe∕ZnS nanocrystals. In contrast to previous experiments, they find that dE∕dT is experimentally identical for all nanocrystal sizes considered and agrees well with the bulk CdSe value. They show that a first order model that only considers the exciton confinement energy can explain the existing experimental dE∕dT values for both epitaxial quantum dots (InAs, In0.6Ga0.4As, GaAs) and colloidal nanocrystals (CdSe, PbS, PbSe).
Guided resonances in photonic crystal slabs studied with terahertz time domain spectroscopy (2005)

Photonic crystal slabs with hexagonal-lattice air-hole arrays are studied experimentally using coherent single-cycle terahertz pulses. Transmission measurements reveal the properties of guided resonances, in both time and frequency domain.
Hydrogenolysis of Glycerol to 1,2-Propanediol Over Clay Based Catalysts (2015)

1,2-propanediol (1,2-PDO) is one of the promising product among the valuable products derived from glycerol and it can be obtained by the catalytic hydrogenolysis of glycerol. Copper-supported clay-based catalysts were prepared with different pore sizes using various ratios of kaolin, Mg, and Al by coprecipitation and applied in the selective hydrogenolysis of glycerol to 1,2-PDO. In recent research, variations of pore volume and pore size could affect the diffusion of reagents within the catalyst due to the collision between reagents or pore wall and reagents. It changes selectivities of each product in hydrogenolysis of glycerol reaction. The physico-chemical properties of the catalysts were analyzed by XRD, N2 physisorption, TPR, CO2-TPD, SEM, and a mercury porosimeter. The Cu/TALCITE 4 catalyst showed 98% 1,2-PDO selectivity with 65% glycerol conversion under the optimized condition of 190 degrees C, 25 bar, and 20 wt% glycerol aqueous solution. It was found that the basic strength and meso-macro pore structure of the catalysts play an important role in glycerol conversion and 1,2-PDO selectivity.
LG-47TYPE II RAF INHIBITORS INHIBIT BRAF MUTATIONS AND TRUNCATED FUSIONS IN PEDIATRIC LOW-GRADE GLIOMAS (2016)

LG-47. TYPE II RAF INHIBITORS INHIBIT BRAF MUTATIONS AND TRUNCATED FUSIONS IN PEDIATRIC LOW-GRADE GLIOMAS Mark W. Kieran1,2, Yu Sun1, Catherine Pilarz1, David Calligaris3, Emily J. Chadwick1, John A. Alberta1, Shakti H. Ramkissoon1,2, Lori A. Ramkissoon1, Veronica Matia Garcia1, Kim Wilkinson1, Michael Kane1, Liliana Goumnerova1,2, Susan N. Chi1,2, Peter Manley1,2, Karen D. Wright1,2, Nathalie Y. Agar1,3, Keith L. Ligon1,3, Rameen Beroukhim1,3, Pratiti Bandopadhayay1,2, Geoffrey Kannan1,2, Rosalind A. Segal1, Levi A. Garraway1, Nathanael S. Gray1, Michael Eck1, Charles D. Stiles1, and Sara J. Buhrlage1; Dana-Farber/Harvard Cancer Center, Boston, MA, USA; Boston Children’s Hospital/Harvard Medical School, Boston, MA, USA; BrighamandWomen’sHospital/HarvardMedical School,Boston,MA,USA PURPOSE: Abnormal signaling of the ras/raf pathway predominates in pediatric low-grade gliomas (PLGGs). Most (75%) non-NF1 low-grade gliomas have Ras-independent BRAF activation, either due to KIAA1549:BRAF truncated fusion duplication or V600E point mutation. While the latter BRAF oncoprotein functions as a monomer, the truncated fusion form requires dimerization. Type I BRAF V600E inhibitors approved for melanoma effectively abrogate monomeric signaling by targeting the “DFG-in” kinase conformation but paradoxically activate wild type RAF dimers. We therefore evaluated Type II RAF inhibitor activity (targeting the “DFG-out” kinase conformation). METHODS: We developed multiple pathway relevant model systems for different BRAF point mutations and KIAA1549 variants using neural progenitor cells from mouse embryos for in vitro, in vivo and mass spectrometry analysis. Additionally, we developed an organoid ex vivo avatar assay from direct patient samples to identify drugs inhibiting these targets. We subsequently treated a single patient with one of two identified compounds. RESULTS: Two different type II BRAF inhibitors capable of inhibiting downstream activation of pERK and tumor progression in vivo for multiple point mutations and BRAF truncated fusion forms were identified. One compound was active on authentic human PLGA cells ex vivo and showed excellent CNS penetration. CONCLUSIONS: Type II BRAF inhibitors possess a unique mechanism of action targeting the BRAF/MEK complex and inhibiting both BRAF point mutations and common structural abnormalities (KIAA1549) in PLGGs. These results have led to the development of a phase I/0/II trial. Neuro-Oncology 18:iii78–iii96, 2016. doi:10.1093/neuonc/now075.47 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
REZOLVE (ANZGOG-1101): A phase 2 trial of intraperitoneal (IP) bevacizumab (bev) for recurrent ascites in advanced, chemotherapy-resistant, epithelial ovarian cancer (CR-EOC). (2018)

10097 Background: We sought to determine the safety and activity of IP bev for recurrent malignant ascites requiring repeated paracenteses, a major problem for women with CR-EOC. Methods: Eligible women had CR-EOC and symptomatic, malignant ascites that recurred within 28 days of their last paracentesis (P-1). Participants had IP bev 5mg/kg instilled at the end of their first therapeutic paracentesis on study (P0). Additional doses of IP bev were allowed at each subsequent paracentesis (P1, P2 etc) if the interval from the last dose was 42 days or more. The primary objective was to determine the proportion alive and free of repeat paracentesis at 42 days. Safety and quality of life were secondary outcomes. Serial samples of blood and ascites were collected for translational studies. The hypothesis was that IP bev would be worthy of further study if the proportion alive and free of repeat paracentesis at 42 days was 54% or more, but not if it was 20% or less. Results: We recruited 24 participants with a median age of 67 years (range 38 – 86), median of 4.5 lines of prior systemic treatment (range 1 – 12), and ECOG performance status of 0-1 in 9, and 2-3 in 15. The numbers of doses of IP bev administered were 1 in 13 participants, 2 in 5, 3 in 2, 4 in 1, and 5 in 1. The proportion free of paracentesis at 42 days using competing risk analysis was 77% (95% CI 58 to 92). Median time from P0 to P1 or death (puncture-free survival) was 48 days (range 8 to 248 days). Median Paracentesis free interval (P0 to P1 or death) was 4.29 (95% CI 2.4 to 5.8 ) times higher following first dose of IP bevacizumab compared with the time between paracenteses prior to study entry (P-1 to P0). Grade 3-4 AEs (number of participants, regardless of attribution) included abdominal pain (4), distension (4), small bowel obstruction (3), nausea (2), fatigue (2), and grade 3 bowel perforation (1). Conclusions: IP bev was safe, active, and warrants further study as a palliative intervention for recurrent ascites in CR-EOC. Clinical trial information: 12611000801910.
Study of hadronic five-body decays of charmed mesons involving K0 (2004)

We study the decay of D0 and D+s mesons into five-body final states including a KS0 and report the discovery of the decay mode Ds+→K S0KS0π+π +π-. The branching ratio for the new mode is Γ(Ds+→KS0K S0π+π-π+) Γ(Ds+→KS0K -π+π+)=0.102±0.029±0.029. We also determine the branching ratio of Γ(D0→K S0π+π+π -π-)Γ(D0→KS 0π+π-)=0.095±0.005±0.007 as well as an upper limit for Γ(D0→KS 0K-π+π+π-) Γ(D0→KS0π+π +π-π-)&lt;0.054 (90% CL). An analysis of the resonant substructure for D0→KS 0π+π+π-π- is also performed.
Regenerable solid imine sorbents (2023)

Two new classes of amine-based sorbents are disclosed. The first class comprises new polymer-immobilized tertiary amine sorbents; the second class new polymer-bound amine sorbents. Both classes are tailored to facilitate removal of acid anhydrides, especially carbon dioxide (CO.sub.2), from effluent gases. The amines adsorb acid anhydrides in a 1:1 molar ratio. Both classes of amine sorbents adsorb in the temperature range from about 20.degree. C. upwards to 90.degree. C. and can be regenerated by heating upwards to 100.degree. C.
A Local Cognitive Pilot Channel (LCPC) for neighbourhood discovery, relaying and cluster based local cognitive information management (2010)

This paper proposes a novel conceptual wireless communication framework in which Mobile Devices (MDs) are cooperating within geographically localized clusters. A Local Cognitive Pilot Channel (LCPC) is introduced for exchanging context information between such neighbouring MDs and for performing nei
Natural history of Christianson syndrome (2020)

Christianson syndrome is an X-linked mental retardation syndrome characterized by microcephaly, impaired ocular movement, severe global developmental delay, hypotonia which progresses to spasticity, and early onset seizures of variable types. Gilfillan et al. [2008] reported mutations in SLC9A6, the gene encoding the sodium/hydrogen exchanger NHE6, in the family first reported and in three others. They also noted the clinical similarities to Angelman syndrome and found cerebellar atrophy on MRI and elevated glutamate/glutamine in the basal ganglia on MRS. Here we report on nonsense mutations in two additional families. The natural history is detailed in childhood and adult life, the similarities to Angelman syndrome confirmed, and the MRI/MRS findings documented in three affected boys.