gebhart/patrepeval huggingface dataset:
3D Bounding Box Estimation Using Deep Learning and Geometry (2016)

We present a method for 3D object detection and pose estimation from a single image. In contrast to current techniques that only regress the 3D orientation of an object, our method first regresses relatively stable 3D object properties using a deep convolutional neural network and then combines these estimates with geometric constraints provided by a 2D object bounding box to produce a complete 3D bounding box. The first network output estimates the 3D object orientation using a novel hybrid discrete-continuous loss, which significantly outperforms the L2 loss. The second output regresses the 3D object dimensions, which have relatively little variance compared to alternatives and can often be predicted for many object types. These estimates, combined with the geometric constraints on translation imposed by the 2D bounding box, enable us to recover a stable and accurate 3D object pose. We evaluate our method on the challenging KITTI object detection benchmark both on the official metric of 3D orientation estimation and also on the accuracy of the obtained 3D bounding boxes. Although conceptually simple, our method outperforms more complex and computationally expensive approaches that leverage semantic segmentation, instance level segmentation and flat ground priors and sub-category detection. Our discrete-continuous loss also produces state of the art results for 3D viewpoint estimation on the Pascal 3D+ dataset.
Using Hydrotime and ABA-time Models to Quantify Seed Quality of Brassicas during Development (1998)

With many seed crops, the most difficult production decision is when to harvest. In indeterminate crops such as Brassica species, early harvests result in immature seed of low vigor while late harvests risk seed deterioration and seed loss due to shattering. To provide a biological basis on which to determine harvest timing, we have characterized seed development in rape seed ( Brassica napus L. `Weststar') and red cabbage ( Brassica oleracea L. Group Capitata) using population-based hydrotime and ABA-time models. These models provide information relevant to assessing physiological maturity, and therefore, seed quality. The hydrotime and ABA-time models quantify germination rate, the uniformity of germination, viability, and the sensitivity of germination to water potential and ABA. Indices derived from these models, along with maximum germination and t 50 values, were used to determine physiological maturity (maximum seed quality) of the seeds during development. The overall trends in seed development were similar in both species: as seeds matured, germination became more uniform and less sensitive to low Ψ and externally applied ABA. The models accurately described germination time courses and final germination percentages except for seeds imbibed at very high concentrations of ABA. In rape seed, physiological maturity was attained several days after maximum seed dry mass, while in red cabbage physiological maturity occurred at or after maximum seed dry mass. Vigor indices were correlated with easily discerned traits such as moisture content and silique phenotypic characteristics. The results of these experiments suggest that hydrotime and ABA-time models can be successfully used to provide a biological basis on which to determine harvest in brassicas.
Formation of Pummerer's ketone from 4-methylphenoxenium ion. An acid-catalyzed solvolysis of N-p-toluenesulfonyl-O-(4-tolyl)-hydroxylamine in p-cresol. (1983)

N-p-Toluenesulfonyl-O-(4-tolyl)hydroxylamine (1) reacts with p-cresol in the presence of trifluoroacetic acid to yield biscresol (2) and Pummerer's ketone (3).
Optimized Thruster Control Algorithm for Drag-free Spacecraft (2008)

Several space missions for fundamental physics research require a disturbance-free environment for their demanding science experiments. The concepts of these missions incorporate a drag-free technology for the spacecraft in order to counteract any external forces and torques. With a disturbance force, originated by the solar radiation pressure and other effects in the range of several Micronewton, micro-propulsion systems are necessary for the spacecraft AOCS. Today, electrical and coldgas engines are available or in development to provide a continuous and controlled thrust in the Micronewton range. Though, the different technologies for the thrust production have different advantages and disadvantages. An ideal thruster control algorithm should be able to deal with these different attributes in an optimal manner.&#13;\nThe content of this paper is the analysis of the currently used methods to control the spacecraft thrusters of a drag-free mission like MICROSCOPE, LISA Pathfinder or LISA and an introduction of a more advanced method. It shows the basic equations and problems of a Thruster Actuation System (TAS) for a simultaneous control of six degrees of freedom.&#13;\nThe focus is on the modification of the standard linear programming algorithm SIMPLEX to meet robustness requirements for the application on a satellite onboard system. This new method takes care of the thrust range limitations (Control Authority) and the dynamics (change of thrust level) of the engines. As a true optimization algorithm, it also provides suitable control strategies for different types of thrusters. In comparison to the standard optimization method, the required memory and computational effort could also be decreased by a special modification, called “Solution Range Placement”.&#13;\nThe algorithm that is developed is finally applied in a closed-loop, nonlinear simulation environment for the LISA mission. In this context, the science mode performance is demonstrated in which two proof masses on board of the LISA spacecraft are isolated from external disturbances along a sensitive axis down to a level of 3×10-15 m/s&lt;sup&gt;2&lt;/sup&gt;/sqrt(Hz).&#13;\nAt the end of the paper, a small overview is given, how numerical instabilities in the original optimization algorithm can be avoided.
Nonparametric estimators of the bivariate survival function under random censoring (1997)

A large number of proposals for estimating the bivariate survival function under random censoring have been made. In this paper we discuss the most prominent estimators, where prominent is meant in the sense that they are best for practical use; Dabrowska's estimator, the Prentice–Cai estimator, Pruitt's modified EM‐estimator, and the reduced data NPMLE of van der Laan. We show how these estimators are computed and present their intuitive background. The asymptotic results are summarized. Furthermore, we give a summary of the practical performance of the estimators under different levels of dependence and censoring based on extensive simulation results. This leads also to a practical advise.
Reversing Tumor Immune Suppression with Intratumoral IL-12: Activation of Tumor-Associated T Effector/Memory Cells, Induction of T Suppressor Apoptosis, and Infiltration of CD8+ T Effectors (2006)

A single intratumoral injection of IL-12 and GM-CSF-loaded slow-release microspheres induces T cell-dependent eradication of established primary and metastatic tumors in a murine lung tumor model. To determine how the delivery of cytokines directly to the microenvironment of a tumor nodule induces local and systemic antitumor T cell activity, we characterized therapy-induced phenotypic and functional changes in tumor-infiltrating T cell populations. Analysis of pretherapy tumors demonstrated that advanced primary tumors were infiltrated by CD4+ and CD8+ T cells with an effector/memory phenotype and CD4+CD25+Foxp3+ T suppressor cells. Tumor-associated effector memory CD8+ T cells displayed impaired cytotoxic function, whereas CD4+CD25+Foxp3+ cells effectively inhibited T cell proliferation demonstrating functional integrity. IL-12/GM-CSF treatment promoted a rapid up-regulation of CD43 and CD69 on CD8+ effector/memory T cells, augmented their ability to produce IFN-gamma, and restored granzyme B expression. Importantly, treatment also induced a concomitant and progressive loss of T suppressors from the tumor. Further analysis established that activation of pre-existing effector memory T cells was short-lived and that both the effector/memory and the suppressor T cells became apoptotic within 4 days of treatment. Apoptotic death of pre-existing effector/memory and suppressor T cells was followed by infiltration of the tumor with activated, nonapoptotic CD8+ effector T lymphocytes on day 7 posttherapy. Both CD8+ T cell activation and T suppressor cell purge were mediated primarily by IL-12 and required IFN-gamma. This study provides important insight into how local IL-12 therapy alters the immunosuppressive tumor milieu to one that is immunologically active, ultimately resulting in tumor regression.
Acoustic particle manipulation in a 40 kHz quarter-wavelength standing wave with an air boundary (2012)

An implementation of a quarter-wavelength standing wave separator that exploits an air drum to achieve the pressure node is presented and characterized experimentally. The air drum configuration was implemented and tested in a set-up with a 40 kHz transducer immersed in a water tank with the quarter-wavelength gap being approximately 9 mm wide. Injection of suspensions of 5 μm and 45 μm diameter polystyrene particles at flow rates of 30 ml/h and 60 ml/h was studied and particle deflection towards the pressure node at the air drum surface was observed for a range of acoustic pressures. Computational results on single particle trajectories show good agreement with the experimental findings for the 45 μm particles, but not for the 5 μm particles. These were considered to behave as aggregates of higher effective dimension, due to their much higher number density relative to the 45 μm particles in the suspensions used. The set-up developed in this study includes a robust method for achieving a pressure node in a quarter-wavelength system and can represent the first step toward the development of an alternative separator configuration in respect to small channel MHz range operated systems for the manipulation of particles streams.
Standard Surgical Protocol to Treat Elbow Dislocations with Radial Head and Coronoid Fractures (2005)

BACKGROUND: The results of elbow dislocations with associated radial head and coronoid fractures are often poor because of recurrent instability and stiffness from prolonged immobilization. We managed these injuries with a standard surgical protocol, postulating that early intervention, stable fixation, and repair would provide sufficient stability to allow motion at seven to ten days postoperatively and enhance functional outcome. METHODS: We retrospectively reviewed the results of this treatment performed, at two university-affiliated teaching hospitals, in thirty-six consecutive patients (thirty-six elbows) with an elbow dislocation and an associated fracture of both the radial head and the coronoid process. Our surgical protocol included fixation or replacement of the radial head, fixation of the coronoid fracture if possible, repair of associated capsular and lateral ligamentous injuries, and in selected cases repair of the medial collateral ligament and/or adjuvanthinged external fixation. Patients were evaluated both radiographically and with a clinical examination at the time of the latest follow-up. RESULTS: At a mean of thirty-four months postoperatively, the flexion-extension arc of the elbow averaged 112° ± 11° and forearm rotation averaged 136° ± 16°. The mean Mayo Elbow Performance Score was 88 points (range, 45 to 100 points), which corresponded to fifteen excellent results, thirteen good results, seven fair results, and one poor result. Concentric stability was restored to thirty-four elbows. Eight patients had complications requiring a reoperation: two had a synostosis; one, recurrent instability; four, hardware removal and elbow release; and one, a wound infection. CONCLUSIONS: Use of our surgical protocol for elbow dislocations with associated radial head and coronoid fractures restored sufficient elbow stability to allow early motion postoperatively, enhancing the functional outcome. We recommend early operative repair with a standard protocol for these injuries.
Combining thermal, tri-stereo optical and bi-static InSAR satellite imagery for lava volume estimates: the 2021 Cumbre Vieja eruption, La Palma (2023)

Determining outline, volume and effusion rate during an effusive volcanic eruption is crucial as it is a major controlling factor of the lava flow lengths, the prospective duration and hence the associated hazards. We present for the first time a multi-sensor thermal-and-topographic satellite data analysis for estimating lava effusion rates and volume. At the 2021 lava field of Cumbre Vieja, La Palma, we combine VIIRS + MODIS thermal data-based effusion rate estimates with DSMs analysis derived from optical tri-stereo Pléiades and TanDEM-X bi-static SAR-data. This multi-sensor-approach allows to overcome limitations of single-methodology-studies and to achieve both, high-frequent observation of the relative short-term effusion rate trends and precise total volume estimates. We find a final subaerial-lava volume of [Formula: see text] with a MOR of 28.8 ± 1.4 m<sup>3</sup>/s. We identify an initially sharp eruption-rate-peak, followed by a gradually decreasing trend, interrupted by two short-lived-peaks in mid/end November. High eruption rate accompanied by weak seismicity was observed during the early stages of the eruption, while during later stage the lava effusion trend coincides with seismicity. This article demonstrates the geophysical monitoring of eruption rate fluctuations, that allows to speculate about changes of an underlying pathway during the 2021 Cumbre Vieja eruption.
Interactive hybrid simulation of large-scale traffic (2011)

We present a novel, real-time algorithm for modeling large-scale, realistic traffic using a hybrid model of both continuum and agent-based methods for traffic simulation. We simulate individual vehicles in regions of interest using state-of-the-art agent-based models of driver behavior, and use a faster continuum model of traffic flow in the remainder of the road network. Our key contributions are efficient techniques for the dynamic coupling of discrete vehicle simulation with the aggregated behavior of continuum techniques for traffic simulation. We demonstrate the flexibility and scalability of our interactive visual simulation technique on extensive road networks using both real-world traffic data and synthetic scenarios. These techniques demonstrate the applicability of hybrid techniques to the efficient simulation of large-scale flows with complex dynamics.
Constant activation of the RAF-MEK-ERK pathway as a diagnostic and therapeutic target in hairy cell leukemia (2013)

The BRAF-V600E mutation defines genetically hairy cell leukemia among B-cell leukemias and lymphomas. In solid tumors, BRAF-V600E is known to aberrantly activate the oncogenic MEK-ERK pathway, and targeted BRAF and/or MEK inhibitors have shown remarkable efficacy in clinical trials in melanoma patients. However, the MEK-ERK pathway status in hairy cell leukemia has not been thoroughly investigated. We assessed phospho-ERK expression in 37 patients with hairy cell leukemia and 44 patients with neoplasms mimicking hairy cell leukemia (40 splenic marginal zone lymphoma, 2 hairy cell leukemia-variant and 2 splenic lymphoma/leukemia unclassifiable) using immunohistochemistry on routine biopsies and/or Western blotting on purified leukemic cells, and correlated the phospho-ERK status with the BRAF-V600E mutation status. Besides confirming the constant presence of BRAF-V600E in all patients with hairy cell leukemia, we observed ubiquitous phospho-ERK expression in this malignancy. Conversely, all 44 cases with neoplasms mimicking hairy cell leukemia were devoid of BRAF-V600E and none expressed phospho-ERK. Furthermore, the two exceptionally rare cases of non-hairy cell leukemia unclassifiable chronic B-cell neoplasms previously reported to be BRAF-V600E(+) on allele-specific polymerase chain reaction lacked phospho-ERK expression as well, suggesting the presence of the mutation in only a small part of the leukemic clone in these cases. In conclusion, our findings support the use of phospho-ERK immunohistochemistry in the differential diagnosis between hairy cell leukemia and its mimics, and establish the MEK-ERK pathway as a rational therapeutic target in this malignancy.
First Trial of Maintenance Friendly Network (MFN) by Switching Spare Field Fibers without Traffic Interruption (2008)

Maintenance friendly network is demonstrated for first time with three SONET protection schemes fed into a ULH system. Traffic can be switched between six field fibers without triggering protection on 1+1, UPSR, or BLSR configurations.
Clinically Localized Prostate Cancer: AUA/ASTRO Guideline, Part II: Principles of Active Surveillance, Principles of Surgery, and Follow-Up (2022)

This guideline aims to inform clinicians treating patients with clinically localized prostate cancer. Continued research and publication of high-quality evidence from future trials will be essential to further improve care for these men.
New erase scheme for DINOR flash memory enhancing erase/write cycling endurance characteristics (2002)

New erase scheme for DINOR (Divided Bit Line NOR) flash memory is proposed and investigated, which utilizes substrate hot electron(SHE) injection instead of FN tunnel injection for erasure. Additional process or alteration of the cell structure is not needed to realize SHE erasure. The cell is formed in a triple well structure. The bottom n-well layer, which surrounds the p-well, is used as electron supply source in the SHE. By adopting SHE for erasure, the electric field required across the tunnel oxide was reduced to 1/4, compared with FN erasure. It needs less than 1 second for erasure, which is sufficient for DINOR operation. It is shown that V th window narrowing during erase/write cycling was significantly reduced by using SHE for erasure, as compared with using FN tunneling. The mechanism of enhanced erase/write cycling endurance is also examined.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Inducible Expression of a Th2-Type CC Chemokine Thymus- and Activation-Regulated Chemokine by Human Bronchial Epithelial Cells (2000)

CCR4 is now known to be selectively expressed in Th2 cells. Since the bronchial epithelium is recognized as an important source of mediators fundamental to the manifestation of respiratory allergic inflammation, we studied the expression of two functional ligands for CCR4, i.e., macrophage-derived chemokine (MDC) and thymus- and activation-regulated chemokine (TARC), in bronchial epithelial cells. The bronchial epithelium of asthmatics and normal subjects expressed TARC protein, and the asthmatics showed more intense expression than the normal subjects. On the other hand, MDC expression was only weakly detected in the asthmatics, but the intensity was not significantly different from that of normal subjects. Combination of TNF-alpha and IL-4 induced expression of TARC protein and mRNA in bronchial epithelial A549 cells, which was slightly up-regulated by IFN-gamma. The enhancement by IFN-gamma was more pronounced in bronchial epithelial BEAS-2B cells, and a maximum production occurred with combination of TNF-alpha, IL-4, and IFN-gamma. On the other hand, MDC was essentially not expressed in any of the cultures. Furthermore, expressions of TARC protein and mRNA were almost completely inhibited by glucocorticoids. These results indicate that the airway epithelium represents an important source of TARC, which potentially plays a role via a paracrine mechanism in the development of allergic respiratory diseases. Furthermore, the beneficial effect of inhaled glucocorticoids on asthma may be at least in part due to their direct inhibitory effect on TARC generation by the bronchial epithelium.
Axonal Proteins Involved in Myelination: Characterization of a Collagen-Like Protein (1997)

An anti-axolemma monoclonal antibody, designated G21.3, has been isolated in order to understand molecular mechanisms involved in myelination. Both biochemical and morphological studies showed that the monoclonal antibody inhibits myelin production by oligodendrocytes in cerebellar slice cultures. On Western blots of axolemma preparations, the antibody recognized 140- and 120-kD proteins. The present study involves the isolation and characterization of the G21.3 antigen. The G21.3-immunoreactive proteins of 140 and 120 kD were purified from the adult rat sciatic nerve and amino acid sequencing of these proteins revealed significant homology to alpha I and alpha II chains of collagen type I. Biochemical and Western blot analysis using pure collagen, collagen I antibody and collagenase D suggest that the antigen isolated from sciatic nerve is collagen. However, immunofluorescence studies using the G21.3 antibody, collagen I antibody, collagenase D and Northern blot analysis using a collagen probe do not fully support the view that the G21.3 antigen in the CNS is also a collagen. We conclude that the G21.3 antigen is a collagen-like protein involved in CNS myelination.
Developmental Regulation of Monoterpene Biosynthesis in the Glandular Trichomes of Peppermint (2000)

Monoterpene production in peppermint (Mentha x piperita L.) glandular trichomes is determined by the rate of biosynthesis, as determined by (14)CO(2) incorporation, and is restricted to leaves 12 to 20 d of age. Using oil glands isolated from peppermint leaves of different ages, in vitro assay of the eight sequential enzymes responsible for the biosynthesis of the principal monoterpene (-)-menthol indicated that all but one biosynthetic enzyme had a very similar developmental profile. Activities were highest in leaves 12 to 20 d of age, with a sharp peak centered at 15 d. The exception, (-)-menthone reductase, the last enzyme of the pathway, exhibited a later peak of activity, which was centered at approximately 21 d. The correlation between in vitro enzyme activity and the rate of biosynthesis measured in vivo suggests that monoterpene formation is controlled mainly by the coordinately regulated activity of the relevant biosynthetic enzymes. Developmental immunoblotting of limonene synthase, which catalyzes the committed step of the pathway, demonstrated a direct correlation between enzyme activity and enzyme protein, suggesting that the dynamic time course for the remaining pathway enzyme activities also reflects the corresponding protein levels. RNA-blot analyses indicated that the genes encoding enzymes of the early pathway steps are transcriptionally activated in a coordinated fashion, with a time course superimpossible with activity measurements and immunoblot data. These results demonstrating coincidental temporal changes in enzyme activities, enzyme protein level, and steady-state transcript abundances indicate that most of the monoterpene biosynthetic enzymes in peppermint are developmentally regulated at the level of gene expression.