gebhart/patrepeval huggingface dataset:
Fluorescence Visualization in Oral Neoplasia: Shedding Light on an Old Problem (2006)

In this issue of Clinical Cancer Research , Poh et al. ([1][1]) show the effectiveness of a simple handheld light (blue excitation light at 400-460 nm) to clarify the true extent of tumor spread and, in turn, guide complete removal of oral cancers in the operating room. Optical changes (specifically
On H Passivation of Si Donors in GaAs Annealed with Plasma‐ Enhanced Chemical Vapor Deposited Silicon Nitride Caps (1991)

Incomplete activation of Si donors in GaAs annealed with nitride caps is not likely due to H passivation from the cap
Reply (2007)

Doheny Retina Institute, Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA
Total synthesis of (.+-.)-velloziolone. (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of (.+-.)-velloziolone.Barry B. Snider and Brad O. BuckmanCite this: J. Org. Chem. 1992, 57, 18, 4883–4888Publication Date (Print):August 1, 1992Publication History Published online1 May 2002Published inissue 1 August 1992https://pubs.acs.org/doi/10.1021/jo00044a024https://doi.org/10.1021/jo00044a024research-articleACS PublicationsRequest reuse permissionsArticle Views561Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
ChemInform Abstract: Redox Catalysis in Free‐Radical Reactions: New, Simple, Convenient Intramolecular Homolytic Aromatic Substitutions. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Application-driven network capacity adaptation for energy efficient ad-hoc networks (2004)

In this paper, we propose a novel technique for reducing the energy consumption in idle mode. Our proposed technique called the network capacity adaptation derives an effective network capacity required by a given application and logically slows down the network capacity when the traffic load is low. By slowing down the logical network capacity, the neighboring mobile stations can stay longer in the power-off mode, significantly saving the energy consumed in idle mode.
Assembling C60 Molecules Involving Fe(II)-η2 Bonding to a Saddle-Shaped Macrocycle (2008)

The saddle-shaped Fe(TMTAA) acts as a shallow cavity divergent receptor toward fullerene C60 molecules involving Fe(II)-η2 coordination on one face of the macrocycle, the 1:1 complex effectively creating a corrugated sheet of inefficiently packed fullerene molecules.
DPP4 Inhibitor Sitagliptin Enhances Lymphocyte Recruitment and Prolongs Survival in a Syngeneic Ovarian Cancer Mouse Model (2021)

Immunity plays a key role in epithelial ovarian cancer (EOC) progression with a well-documented correlation between patient survival and high intratumoral CD8+ to T regulatory cell (Treg) ratios. We previously identified dysregulated DPP4 activity in EOCs as a potentially immune-disruptive influence contributing to a reduction in CXCR3-mediated T-cell infiltration in solid tumours. We therefore hypothesized that inhibition of DPP4 activity by sitagliptin, an FDA-approved inhibitor, would improve T-cell infiltration and function in a syngeneic ID8 mouse model of EOC. Daily oral sitagliptin at 50 mg/kg was provided to mice with established primary EOCs. Sitagliptin treatment decreased metastatic tumour burden and significantly increased overall survival and was associated with significant changes to the immune landscape. Sitagliptin increased overall CXCR3-mediated CD8+ T-cell trafficking to the tumour and enhanced the activation and proliferation of CD8+ T-cells in tumour tissue and the peritoneal cavity. Substantial reductions in suppressive cytokines, including CCL2, CCL17, CCL22 and IL-10, were also noted and were associated with reduced CD4+ CD25+ Foxp3+ Treg recruitment in the tumour. Combination therapy with paclitaxel, however, typical of standard-of-care for patients in palliative care, abolished CXCR3-specific T-cell recruitment stimulated by sitagliptin. Our data suggest that sitagliptin may be suitable as an adjunct therapy for patients between chemotherapy cycles as a novel approach to enhance immunity, optimise T-cell-mediated function and improve overall survival.
Imaging the Brain Neuronal Network with Diffusion MRI: A Way to Understand Its Global Architecture (2006)

In order to better understand the high complexity of the brain, the detailed study of its individual components clearly seems insufficient. The backbone of complexity in the nervous system is composed of the large scale architectural characteristics of the neuronal network. Newly, by the advent of MR tractography, its investigation is accessible. We report on two important network characteristics that were already guessed from functional investigations and animal ex vivo studies, but never directly addressed in the human subject, ie the small world and hierarchical architecture of the human long-range brain axonal network.
DCLK1 and DNA Damage Response (2020)

Genome integrity is constantly monitored by sophisticated cellular networks, collectively termed as the DNA damage response (DDR). The DDR is a signaling network that includes cell cycle checkpoints and DNA repair and damage tolerance pathways. Failure of the DDR or associated events causes various diseases, including cancer. DDR is primarily mediated by phosphatidylinositol-3-kinase-like protein kinase (PIKKs) family members ataxia-telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related protein (ATR). However, one of the many unanswered questions regarding these signal-transduction pathways is: how does the cell turn the DDR signals on? There was no conclusive demonstration of the involvement of a specific sensory kinase in DDR signals until our recent research on the DCLK1 role in regulating ATM after genotoxic injury. Currently, various studies are demonstrating the importance of DCLK1 in DNA damage response. Here, we discuss the novel insights into the role of DCLK1 in DNA damage response.
A Novel Approach for Continuous Monitoring of Partial Discharge Phenomena on Medium Voltage Equipments (2018)

Electrical distribution grids consist of many Medium Voltage (MV) devices, each one of them being a possible cause of fault. The demand for their increasing reliability and decreasing maintenance/replacement costs, together with the high number of installed apparatuses, is turning the focus of the condition assessment to smart solutions, integrable in networks, able to evaluate autonomously the condition of the electrical asset and, in case of anomalies, to request for man-operated support. In this paper, a novel approach to the continuous monitoring of PD phenomena in MV grids will be described. The devised solution addresses the requirements of the MV grids in that the system is non-invasive and low cost. PD data acquisition and processing systems are fully automatic, with the relevant assessment of the conditions of the MV piece of equipment. A comprehensive description of the proposed technological solution is reported, focusing mainly on the automatic acquisition and processing of PD data, automatic noise rejection and the recognition of increasing PD trend as a tool to trigger warning signals. To show the effectiveness of the proposed approach, case studies will be reported for various MV pieces of equipment, particularly on Switchgears and Ring Main Units.
Abstract 034: Resilience of Isolated, Perfused Cerebral Penetrating Microarterioles to Angiotensin II (Ang II) Contractions Depends on Local Generation of Prostaglandin D 2 (PGD 2 ) (2018)

The brain depends on a continuous supply of blood for its oxygenation, whereas the kidney is over-perfused for its metabolic needs in order to provide sufficient plasma to form a glomerular filtrate. Thus, the brain requires resilience to vasoconstriction to prevent ischemia and vascular cognitive impairment, but the mechanisms are unclear. Methods and Results: Single penetrating cerebral microarterioles (CMAs, 12-18μM) were dissected from the frontal cortex and single renal afferent arterioles (RAAs, 8-12μM) from the kidney cortex to investigate the hypothesis that CMAs deploy unique mechanisms to provide resilience to Ang II vasoconstriction. Individual arteriolar genes were assessed by RNAseq or RT-PCR of endothelial cells (ECs). The mRNA for lipocalin type PGD 2 synthase (LPGDS) and the PGD 1 receptor (PD1R) were &gt; 3,000-fold higher in CMAs than RAAs whereas RAAs expressed 3-fold more mRNA for thromboxane A 2 synthase. Both microarterioles had similar expression of AT1Rs. Endothelial cells cultured from these vessels had similar patterns of gene expression. Single isolated perfused RAAs contracted strongly with Ang II (at 10 -6 mol·l -1 ; -47 ± 2%; P&lt;0.005) whereas CMAs were totally resistant to Ang II (0.1 ± 0.1%; NS), yet both contracted similarly to endothelin I or perfusion pressure (n = 6 per group). However, CMAs from COX 1 -/- (vs +/+) mice did contract with Ang II (-15 ± 2 vs 0.1 ± 0.1%; P&lt;0.01) and contracted with Ang II after incubation with parecoxib (vs vehicle) to block COX2 (-7 ± 3 vs 0.1 ± 0.1%; P&lt;0.01) or after dual blockade of COX1 + 2 (-20 ± 2%; P&lt;0.01) or after incubation with AT-56 (vs vehicle) to block LPGDS (-20 ± 3 vs 0.1 ± 0.1%; P&lt;0.01). During LPGDS blockade, incubation of CMAs with BW245c (stable PD1R agonist) reduced Ang II contraction &gt; 65% (-8 ± 2%; P&lt;0.01). In contrast, COX blockade reduced Ang II contractions of RAAs, indicating opposing effects of PGs on cerebral and renal vessels. Measurements of cerebral and renal blood flow and MAP in anesthetized mice confirmed selective renal vasoconstriction with Ang II, yet selective cerebral vasodilation with BW245c. Perspective: Resilience against Ang II vasoconstriction in cerebral arterioles depends on the generation of PGD 2 and could be a therapeutic target for vascular dementia and stroke.
Beam-scan sensor node: Reliable sensing of human interactions in organization (2009)

We have developed a wearable sensor node with a low power and high detection rate by using sequential control of multiple infrared (IR) modules. Conventional sensor nodes are not practical in terms of size, sensing performance, and working hours. Therefore, we devised a name-tag-size (73 × 98 × 9 mm) sensor node, which captures face-to-face interactions within 2 meters and within an angle of 60°. The sensor node weighs 62 grams and works for more than twenty hours with a small 5-gram Li-ion battery. The sensor uses the beam-scan technique, in which four infrared modules, placed horizontally on the node, are controlled to be on and off sequentially, and this operation is done synchronously with other nodes. The beam-scan technique enables low-power operation with a consumption current of 7.2 mA and 21 hours of operation. We had tested the sensor node in a field trial that collected sensor data for six months from 20 people and had demonstrated that this technique is practical. Feedback from sensing data reminded us of the importance of meeting frequency and this improved our work habits.
Genetic Variation of Porphyromonas gingivalis Genes Encoding Gingipains, Cysteine Proteinases with Arginine or Lysine Specificity (1998)

Porphyromonas gingivalis hemagglutinating cysteine proteinases (gingipains) are considered as important virulence factors in the development of adult periodontitis. Using Southern blot analysis it was determined that genes of three distinct but related gingipains (gingipain-R1, gingipain-R2 and gingipain-K) were present in all tested strains including HG66, ATCC 33277, W50, E-20-1, EM-3, 381, A7436, and IKG5, with a region encoding a part of the hemagglutinin domain of gingipain-R1 and gingipain-K showing considerable variability. In contrast, the loci encoding gingipain-R1 (rgp1) and gingipain-R2 (rgp2) were strongly conserved excluding the concurrent occurrence of other gingipain-R-like genes such as cpgR and agp. Significantly, no evidence could be found to support the expression of a gene coding for the putative proteinase porphypain, an enzyme suggested to have both gingipain-R and gingipain-K activity.
Evaluation of Links Between High-Density Lipoprotein Genetics, Functionality, and Aortic Valve Stenosis Risk in Humans (2013)

Results of the present study suggest that, based on HDL genetics and HDL functionality, HDL metabolism does not seem to predict the risk of AVS. Because of our limited sample size, additional studies are needed to confirm these findings.
A Phl p 7-specific IgG4 antibody inhibits allergic patients IgE cross-reactivity to allergens from the EF-hand family: importance of affinity and degree of cross-reactivity (2014)

Methods and results Sequence comparison showed a comparable sequence identity of approximately 70% between the 2EF-hand pollen allergens (Timothy grass: Phl p 7; Alder: Aln g 4; Birch: Bet v 4; Turnip rape: Bra r 1; Lamb s quarter: Che a 3; Olive: Ole e 3) and a lower sequence identity of 44% with the 4EF-hand allergen from olive pollen (Ole e 8). While patients IgE showed extensive cross-reactivity with the EF-hand allergens, the Phl p 7-specific IgG4 showed limited cross-reactivity. Best cross-reactivity was observed with Ole e 3 whereas the other EF-hand allergens were less recognized by the Phl p 7-specific IgG4 in dot blot experiments. Calcium-depletion experiments showed that the binding of the Phl p 7-specific IgG4 depended on the presence of calcium. Using peptidespecific antisera the binding site of the IgG4 was located in the C-terminal portion of the allergen which contains the second calcium-binding EF-hand motif. Biacore experiments revealed interesting differences regarding the affinity of the Phl p 7-specific IgG4. Phl p 7 and Ole e 3 were recognized with the highest affinity (KD s: Phl p 7: 2,11x10-9M; Ole e 3: 6,18x10-9M) whereas the affinities to the other cross-reactive allergens was much lower (Bet v 4: 6,26x10-6M; Bra r 1: 6,57x10-6M; Aln g 4: 7,93x10-6M). The cross-inhibition of patients IgE reactivity to the EF-hand allergens and the inhibition of allergen-induced basophil activation obtained with the Phl p 7-specific IgG4 followed its intensity of cross-reactivity and affinity with the homologous allergens.
The polarized absorption spectroscopy as a novel method for determining the orientational order of poled nonlinear optical polymer films (1994)

A novel method for the determination of the order parameter A2 in anisotropic films with ∞ mm-symmetry, such as poled nonlinear optical polymer films, is presented. The order parameter A2 is believed to shed light on the understanding of the poling mechanism. Light with polarization parallel to the plane of incidence is used to study the absorption behavior of thin poled polymer films as a function of the angle of incidence. Moreover, the order parameter of unpoled samples can easily be determined. The results for the order parameter A2 obtained by polarized absorption spectroscopy are in good agreement with corresponding second-harmonic generation measurements.
2-Acetamido-N-benzyl-1,4-imino-1,2,4-trideoxy-L-arabinitol 0.33-hydrate (2005)

The solid-state conformation of the title compound, C14H20N2O3·0.33H2O, a potent hexosaminidase inhibitor, prepared from d-lyxonolactone, has been established by X-ray crystallography. The asymmetric unit contains three mol­ecules, which have very similar conformations, together with a mol­ecule of water.
Efficacy and safety of second-line agents for treatment of metastatic castration-resistant prostate cancer progressing after docetaxel. A systematic review and meta-analysis (2015)

In docetaxel-pretreated patients enzalutamide, abiraterone-prednisone and cabazitaxel-prednisone can improve overall survival of patients, compared to placebo or to best of care at the time of study (mitoxantrone-prednisone). Agents targeting the androgen axis (enzalutamide, abiraterone, orteronel) significantly prolonged rPFS, compared to placebo. Further investigation is warranted to evaluate the benefit of combination or sequential administration of these agents. Large-scale studies are also necessary to evaluate the impact of relevant toxic effects observed in a limited number of patients (e.g., enzalutamide-induced seizures, orteronel-induced pancreatitis, and others).
Distribution of subsets of blood monocytic cells throughout life (2019)

Currently, it is well established that monocytes are a heterogeneous type of cell consisting of phenotypically and functionally distinct subpopulations found to be numerically altered in blood in patients with a wide variety of disease conditions, such as infection, autoimmunity, respiratory and cardiovascular diseases, and inflammatory disorders.1,2 Thus, 3 subpopulations of circulating monocytic cells have been identified based on expression of the CD14 LPS receptor and the CD16 low-affinity Fc IgG receptor: (1) CD14hiCD16− classical monocytes (cMos), (2) CD14hiCD16+ intermediate monocytes (iMos), and (3) CD14−/loCD16+ nonclassical monocytes (ncMos).
2,4-D and IAA Amino Acid Conjugates Show Distinct Metabolism in Arabidopsis (2016)

The herbicide 2,4-D exhibits an auxinic activity and therefore can be used as a synthetic and traceable analog to study auxin-related responses. Here we identified that not only exogenous 2,4-D but also its amide-linked metabolite 2,4-D-Glu displayed an inhibitory effect on plant growth via the TIR1/AFB auxin-mediated signaling pathway. To further investigate 2,4-D metabolite conversion, identity and activity, we have developed a novel purification procedure based on the combination of ion exchange and immuno-specific sorbents combined with a sensitive liquid chromatography-mass spectrometry method. In 2,4-D treated samples, 2,4-D-Glu and 2,4-D-Asp were detected at 100-fold lower concentrations compared to 2,4-D levels, showing that 2,4-D can be metabolized in the plant. Moreover, 2,4-D-Asp and 2,4-D-Glu were identified as reversible forms of 2,4-D homeostasis that can be converted to free 2,4-D. This work paves the way to new studies of auxin action in plant development.
Classification-based strategies for combining multiple 5-w question answering systems (2009)

We describe and analyze inference strategies for combining outputs from multiple question answering systems each of which was developed independently. Specifically, we address the DARPA-funded GALE information distillation Year 3 task of finding answers to the 5-Wh questions (who, what, when, where, and why) for each given sentence. The approach we take revolves around determining the best system using discriminative learning. In particular, we train support vector machines with a set of novel features that encode systems’ capabilities of returning as many correct answers as possible. We analyze two combination strategies: one combines multiple systems at the granularity of sentences, and the other at the granularity of individual fields. Our experimental results indicate that the proposed features and combination strategies were able to improve the overall performance by 22% to 36% relative to a random selection, 16% to 35% relative to a majority voting scheme, and 15% to 23% relative to the best individual system. Index Terms: Question answering, Systems for spoken language understanding
Conception d'un système de chauffage adapté aux logements à très faibles besoins énergétiques : micro- cogénération et ventilation double-flux (2010)

International audience
Galvanic Test Panels for Accelerated Corrosion Testing of Coated Al Alloys: Part 1—Concept (2013)

A test sample incorporating a coated and scribed Al alloy panel and uncoated through-hole fasteners was designed to provide accelerated response during atmospheric corrosion testing in the field or in laboratory chambers. Protective coatings that would take many months to show signs of degradation on normal scribed samples with no galvanic connection exhibited corrosion in much shorter times when uncoated Ti alloy or stainless steel fasteners were used, particularly in conjunction with scribes through the coating. The results after three weeks of exposure to ASTM B117 correlated well with long-term beach exposure, allowing rapid ranking of different coating systems. Of the fastener materials studied, visual observation indicated that the worst attack occurred near Type 316 (UNS S31600) stainless steel (SS316) fasteners even though Ti-6Al-4V fasteners are more noble. The volume of AA2024-T3 (UNS A92024) lost during the exposure, as determined by an optical profilometer, was also largest for samples with SS316 fasteners. Scanning Kelvin probe measurements across the scribes on one of the coating systems showed that, after exposure in an ASTM B117 salt fog chamber, the potential was lowest for scribes next to SS316 fasteners. The difference between SS316 and Ti-6Al-4V was explained by the available cathodic current, which was measured in chloride solution.
Antennes dédiées à des terminaux portaux optimisés par algorithme génétique (2010)

National audience
Nuclear Magnetic Resonance Study of Water Mobility in Pasta Filata and Non-Pasta Filata Mozzarella (2001)

Changes in molecular mobility of water in pasta filata and non-pasta filata Mozzarella cheeses were investigated during the first 10 d of storage using nuclear magnetic resonance (NMR) relaxation techniques. Water in pasta filata Mozzarella was classified into two fractions by spin-spin relaxation times, T21 and T22, and corresponding proton intensities, A1 and A2, representing low and high molecular mobility, respectively. Increase in A1 (and decrease in A2) suggested that, there was a redistribution of water from more- to less-mobile fraction (from T22 to T21 fraction) during the first 10 d of storage. The NMR data did not indicate the two-state behavior of water molecules in non-pasta filata Mozzarella. However, the T2 values of non-pasta filata Mozzarella were comparable to the T21 values of pasta filata Mozzarella indicating that the molecular mobility of water in non-pasta filata Mozzarella is comparable to that of the less mobile water fraction in pasta filata Mozzarella. Generally, T2 and T1 values of pasta filata and non-pasta filata Mozzarella cheeses increased during the 10-d storage. This is believed to be due to structural changes in the protein matrix.
60‐1: Invited Paper: Mass Transfer Throughput and Yield Using Elastomer Stamps (2021)

Emissive displays using microLEDs will be bright, rugged, and efficient. Realization of microLED displays requires high‐yield mass transfer processes that rapidly assemble millions of micron‐scale devices onto non‐native display substrates. A candidate mass transfer process uses polydimethylsiloxane (PDMS) elastomer stamps to retrieve and transfer large arrays of microLEDs. This paper will review the fundamentals of elastomer stamp mass transfer and will examine paths to satisfy the demanding throughput requirements for display manufacturing.