gebhart/patrepeval huggingface dataset:
CD30 on extracellular vesicles from malignant Hodgkin cells supports damaging of CD30 ligand-expressing bystander cells with Brentuximab-Vedotin,in vitro (2016)

The goal of targeted immunotherapy in cancer is to damage both malignant and tumor-supporting cells of the microenvironment but spare unaffected tissue. The malignant cells in classical Hodgkin lymphoma (cHL) selectively express CD30. They release this receptor on extracellular vesicles (EVs) for the tumor-supporting communication with CD30 ligand (CD30L)-positive bystander cells. Here, we investigated how CD30-positive EVs influence the efficacy of the CD30 antibody drug conjugate (ADC) Brentuximab Vedotin (SGN-35). The malignant cells and the EVs expressed the active sheddase ADAM10. ADAM10 cleaved and released the CD30 ectodomain (sCD30), causing a gradual depletion of SGN-35 binding sites on EVs and creating a soluble competitor of the ADC therapy. In a 3D semi-solid tumor microenvironment model, the EVs were retained in the matrix whereas sCD30 penetrated readily into the surrounding culture medium. This resulted in a lowered ratio of EV-associated CD30 (CD30EV) to sCD30 in the surrounding medium in comparison to non-embedded cultures. A low percentage of CD30EV was also detected in the plasma of cHL patients, supporting the clinical relevance of the model. The adherence of CD30EV but not sCD30 to CD30-/CD30L+ mast cells and eosinophils allowed the indirect binding of SGN-35. Moreover, SGN-35 damaged CD30-negative cells, provided they were loaded with CD30+ EVs.
Effects of Copper and Cross-Linking on the Extracellular Matrix of Tissue-Engineered Arteries (2005)

In many cases, the mechanical strengths of tissue-engineered arteries do not match the mechanical strengths of native arteries. Ultimate arterial strength is primarily dictated by collagen in the extracellular matrix, but collagen in engineered arteries is not as dense, as organized, or as mature as collagen in native arteries. One step in the maturation process of collagen is the formation of hydroxylysyl pyridinoline (HP) cross-links between and within collagen molecules. HP cross-link formation, which is triggered by the copper-activated enzyme lysyl oxidase, greatly increases collagen fibril stability and enhances tissue strength. Increased cross-link formation, in addition to increased collagen production, may yield a stronger engineered tissue. In this article, the effect of increasing culture medium copper ion concentration on engineered arterial tissue composition and mechanics was investigated. Engineered vessels grown in low copper ion concentrations for the first 4 weeks of culture, followed by higher copper ion concentrations for the last 3 weeks of culture, had significantly elevated levels of cross-link formation compared to those grown in low copper ion concentrations. In contrast, vessels grown in high copper ion concentrations throughout culture failed to develop higher collagen cross-link densities than those grown in low copper ion concentrations. Although the additional cross-linking of collagen in engineered vessels may provide collagen fibril stability and resistance to proteolysis, it failed to enhance global tissue strength.
Effect of Active and Passive Function of the Posterosuperior Rotator Cuff on Compensatory Muscle Loads in the Shoulder (2022)

The findings encourage the exploration of treatment procedures that mimic the active function of the PSRC when the rotator cuff itself is irreparable.
An Analysis of SVD for Deep Rotation Estimation (2020)

Symmetric orthogonalization via SVD, and closely related procedures, are well-known techniques for projecting matrices onto $O(n)$ or $SO(n)$. These tools have long been used for applications in computer vision, for example optimal 3D alignment problems solved by orthogonal Procrustes, rotation averaging, or Essential matrix decomposition. Despite its utility in different settings, SVD orthogonalization as a procedure for producing rotation matrices is typically overlooked in deep learning models, where the preferences tend toward classic representations like unit quaternions, Euler angles, and axis-angle, or more recently-introduced methods. Despite the importance of 3D rotations in computer vision and robotics, a single universally effective representation is still missing. Here, we explore the viability of SVD orthogonalization for 3D rotations in neural networks. We present a theoretical analysis that shows SVD is the natural choice for projecting onto the rotation group. Our extensive quantitative analysis shows simply replacing existing representations with the SVD orthogonalization procedure obtains state of the art performance in many deep learning applications covering both supervised and unsupervised training.
Tight-Binding Quantum Chemical Molecular Dynamics Study on Depth Profile Prediction in Low Energy Boron Implantation Process (2005)

Creation of shallow junction for the future generation LSI is a crucial step in semiconductor industry and low-energy boron implantation process is considered to be a key technology. In this study, we have statistically investigated the effects of orientation of implantation on the dynamic behavior of boron implantation process into hydrogen-terminated Si(001) 2×1 surface by using our original tight-binding quantum chemical molecular dynamics method, which is over 5,000 times faster than conventional first-principle molecular dynamics method. It was found that depth profile of boron implantation can be controlled by orientation of boron implantation and the shallowest implantation depth was obtained in the case of tilt angle equal to 7° among the investigated tilt angles of 0°, 7°, 15°, 22.5°, 30° and 45° at the initial boron energy of 100 eV. At the boron implantation process of over 1 keV energy the tilt angle of 7° has been employed experimentally and the same tilt angle was predicted to be the best even at low-energy region of 100 eV. Furthermore, we investigated the effect of rotation angle on the depth profile and at all the investigated tilt angles the average implantation depth becomes shallower for rotation angle of 45° that is along &lt;011&gt; direction, than for rotation angle of 0° that is along &lt;001&gt;. Hence, the shallowest depth profile was obtained in the case of tilt angle of 7° and rotation angle of 45°, where the distribution of intruded boron atom was more concentrated than for the same tilt angle but rotation angle of 0°. The effect of tilt and rotation angles on the boron implantation process has not been clarified experimentally at low-energy boron implantation process of less than 1 keV and hence we concluded that theoretical optimization of low-energy boron implantation process has been succeeded by means of our original tight-binding quantum chemical molecular dynamics method.
Anesthesia Unmasking Benign Wolff-Parkinson-White Syndrome (1989)

Received from the Department of Anesthesiology, New York University Medical Center, New York, New York. Accepted for publication September 28, 1988. Address correspondence to Dr. Lubarsky, Department of Anesthesia, PO Box 3094, Duke University Medical Center, Durham, NC 27710.
Polarization analysis of a balloon-borne solar magnetograph (1987)

The 10(exp -5) polarization specification for the Balloon-borne Vector Magnetograph (BVM) can be met. The 10(exp -5) specification is shown to be a limitation on the diattenuation and retardance along the chief ray path through the optical system, such that the magnitude of the polarization aberration piston term is constrained to be less than .5(10)(exp -5). Coating specification sheets are provided which will ensure that the polarization sensitivity of the BVM will be less than 10(exp -5). An optical design is provided for a vector magnetograph. Finally, to provide a concrete mathematical meaning for polarization sensitivity, the polarization aberration matrix is averaged of the exit pupil. This shows that the coupling between circular and linear states depends only on the magnitude of the polarization aberration piston term.
Compact amperometric solid-electrolyte sensor for detection of NO/sub 2/ in ppb range (2002)

A solid-state amperometric sensor for NO/sub 2/ was designed by attaching a Na/sup +/ conductor (NASICON) based device with an NaNO/sub 2/ layer deposited on the counter electrode. With the sensing electrode being polarized at a constant potential relative to the reference Au electrode, electric current flowing through the device under exposure to NO/sub 2/ was measured as the sensing signal. The current response was almost linear to the NO/sub 2/ concentration in the range from 10 ppb to 1 ppm at 150/spl deg/C. The 90% response time to even 20 ppb NO/sub 2/ was ca. 60 s. The NO/sub 2/ sensitivity was hardly affected by the coexistence of CO/sub 2/, H/sub 2/O and O/sub 2/. A sensing mechanism is proposed from the sensing characteristics obtained.
A test set for LEDs life model estimation (2010)

Life models relate the time to failure to the applied stress. They can be derived starting from knowledge of chemical/physical phenomena involved in the ageing process caused by the stress or by means of regressive techniques on data acquired in ALT-based procedure. Anyway, experimental tests are needed. This paper deals with a test system implemented to estimate a life model for LEDs where the forward current is considered as stress.
Heat Transfer Behavior of Oxide Nanoparticles in Pool Boiling Experiment (2006)

The heat transfer characteristics of silica (SiO2), ceria (CeO2), and alumina (Al2O3) nanofluids at 0.5% concentration and particle size of 10nm and 20 nm in pool boiling have been analyzed. The influence of acidity on heat transfer has been studied. The pH value of the nanosuspensions is important from the point of view that it determines the stability of the particles, their mutual interactions towards the wire. When there is no particle deposition on the wire, the nanofluid with any oxide suspension increases CHF by about 50% within uncertainty limits regardless of the type of the oxide particle and its size. The extent of oxidation on the wire impacts CHF, and is influenced by the chemical composition of nanofluids in buffer solutions. Amorphous oxides (SiO2) are generally more disordered and less closely packed compared to the crystalline oxides such as CeO2 and Al2O3. The arrangement of the atoms within the unit cell and the layer of water molecules at the surface possibly influence the natural convection as well as the CHF. The boiling regime is further extended to higher heat flux when there is agglomeration on the wire. This agglomeration allows high heat transfer through interagglomerate pores, resulting in a nearly 3-fold increase in CHF. This deposition occurs for the charged 10 nm silica particle, and was not seen for other oxide particles. The chemical composition, oxidation and packing of the particles within the deposition on the wire are shown to be the reasons for the extension of the boiling regime and the net enhancement of the Critical Heat Flux.
Urinary dysfunction in transgenic sickle cell mice: model of idiopathic overactive bladder syndrome (2019)

Voiding abnormalities are common among the sickle cell disease (SCD) population, among which overactive bladder (OAB) syndrome is observed at rates as high as 39%. Although detrusor overactivity is the most common cause of OAB, its molecular pathophysiology is not well elucidated. The nitric oxide (NO) signaling pathway has been implicated in the regulation of lower genitourinary tract function. In the present study, we evaluated the role of the NO signaling pathway in voiding function of transgenic SCD mice compared with combined endothelial and neuronal NO synthase gene-deficient mice, both serving as models of NO deficiency. Mice underwent void spot assay and cystometry, and bladder and urethral specimens were studied using in vitro tissue myography. Both mouse models exhibited increased void volumes; increased nonvoiding and voiding contraction frequencies; decreased bladder compliance; increased detrusor smooth muscle contraction responses to electrical field stimulation, KCl, and carbachol; and increased urethral smooth muscle relaxation responses to sodium nitroprusside compared with WT mice. In conclusion, our comprehensive behavioral and functional study of the SCD mouse lower genitourinary tract, in correlation with that of the NO-deficient mouse, reveals NO effector actions in voiding function and suggests that NO signaling derangements are associated with an OAB phenotype. These findings may allow further study of molecular targets for the characterization and evaluation of OAB.
High-Current Backside-Illuminated Photodiode Array Module for Optical Analog Links (2010)

We have developed a high-current photodiode (PD) array module that consists of a beam splitter, which splits a light beam from a single-mode fiber into four beams with identical powers, a backside-illuminated InGaAs p-i-n PD array, and a two-stage Wilkinson RF power combiner. To obtain a linear PD response, the PD is equipped with a partially depleted absorber, which reduces the bias voltage. To prevent thermal failure, the backside-illuminated PD structure is used, which reduces the thermal resistivity. The beam splitter is fabricated using optical contacts at the SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> interfaces between a coating film and a neighboring prism to prevent degradation of the adhesive glue at the prism interfaces along the optical path; therefore, light with a power of a watt level can be used. The two-stage Wilkinson combiner combines four RF outputs of the PD array into a single-RF output through a K connector; the combiner also works as an impedance-matching circuit. Experimental results reveal that an RF power output of 29.0 dBm can be obtained at a frequency of 5 GHz, and good intermodulation distortion characteristics with a third-order intercept point of 32.5 dBm can be achieved.
Fertility restoration of maize CMS‐C altered by a single amino acid substitution within the Rf4 bHLH transcription factor (2019)

Type C cytoplasmic male sterility (CMS-C) is the most commonly used form of CMS in maize hybrid seed production. Restorer of fertility 4 (Rf4), the major fertility restorer gene of CMS-C, is located on chromosome 8S. To positionally clone Rf4, a large F3 population derived from a cross between a non-restorer and restorer (n = 5104) was screened for recombinants and then phenotyped for tassel fertility, resulting in a final map-based cloning interval of 12 kb. Within this 12-kb interval, the only likely candidate for Rf4 was GRMZM2G021276, a basic helix-loop-helix (bHLH) transcription factor with tassel-specific expression. The Rf4 gene product contains a nuclear localization signal and is likely to not interact directly with the mitochondria. Sequence analysis of Rf4 revealed four encoded amino acid substitutions between restoring and non-restoring inbreds, however only one substitution, F187Y, was within the highly conserved bHLH domain. The hypothesis that Rf4 restoration is altered by a single amino acid was tested by using clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR associated protein 9 (Cas9) homology directed repair (HDR) to create isogenic lines that varied for the F187Y substitution. In a population of these CRISPR-Cas9 edited plants (n = 780) that was phenotyped for tassel fertility, plants containing F187 were completely fertile, indicating fertility restoration, and plants containing Y187 were sterile, indicating lack of fertility restoration. Structural modeling shows that this amino acid residue 187 is located within the four helix bundle core, a critical region for stabilizing dimer conformation and affecting interaction partner selection.
Subpicomolar Sensing of δ-Opioid Receptor Ligands by Molecular-Imprinted Polymers Using Plasmon-Waveguide Resonance Spectroscopy (2005)

Here we report, for the first time, the formation of a biomimetic covalently imprinted polymeric sensor for a target ligand, the delta-opioid G-protein coupled receptor agonist DPDPE, which reproducibly exhibits subpicomolar binding affinity in an aqueous environment. In addition to having a well-defined and homogeneous binding site, the imprinted polymer template is quite stable to storage in both the dry and wet states and has at least 6 orders of magnitude higher affinities than exhibited by similar peptide-based molecular-imprinted polymers (MIPs) thus far. A highly sensitive optical detection methodology, plasmon-waveguide resonance spectroscopy, was employed, capable of measuring binding in real time and discriminating between ligand molecules, without requiring labeling protocols (fluorophores or radioisotopes). The DPDPE-imprinted polymer showed a broad structure-activity relationship profile, not unlike that found for protein receptors. Such sensitivity and robustness of MIPs suggests potential applications ranging from biowarfare agent detection to pharmaceutical screening.
DStat: A Versatile, Open-Source Potentiostat for Electroanalysis and Integration (2015)

Most electroanalytical techniques require the precise control of the potentials in an electrochemical cell using a potentiostat. Commercial potentiostats function as "black boxes," giving limited information about their circuitry and behaviour which can make development of new measurement techniques and integration with other instruments challenging. Recently, a number of lab-built potentiostats have emerged with various design goals including low manufacturing cost and field-portability, but notably lacking is an accessible potentiostat designed for general lab use, focusing on measurement quality combined with ease of use and versatility. To fill this gap, we introduce DStat (http://microfluidics.utoronto.ca/dstat), an open-source, general-purpose potentiostat for use alone or integrated with other instruments. DStat offers picoampere current measurement capabilities, a compact USB-powered design, and user-friendly cross-platform software. DStat is easy and inexpensive to build, may be modified freely, and achieves good performance at low current levels not accessible to other lab-built instruments. In head-to-head tests, DStat's voltammetric measurements are much more sensitive than those of "CheapStat" (a popular open-source potentiostat described previously), and are comparable to those of a compact commercial "black box" potentiostat. Likewise, in head-to-head tests, DStat's potentiometric precision is similar to that of a commercial pH meter. Most importantly, the versatility of DStat was demonstrated through integration with the open-source DropBot digital microfluidics platform. In sum, we propose that DStat is a valuable contribution to the "open source" movement in analytical science, which is allowing users to adapt their tools to their experiments rather than alter their experiments to be compatible with their tools.
Problema identifikaci avtobiograficseszkogo geroja ili «szmerty avtora»? (2000)

To the autobiographical character of Remizov's prose several works were consacred in the literary history. However, they do not specify the "subjectivism" of the text exactly. In the article, we attempted to reveal it introducing the term "autobiographic hero". Objectification of the character of the autobiographic hero takes place in the short story of Remizov as a spirit in pagan's sense connected to the low culture, or as an internal voice of the text which is shaped in quasi-personal narration. In Remizov's meta-narration, the presence of the author practically is not perceptible. Due to it, some principles of Remizov's poetics could be approached to the principles set forth in R. Barthes work "La mort l'auteur".
Role of Nitric Oxide in the Physiology of Erection1 (1995)

Penile erection is understood to be a neurally regulated physiologic event, although the underlying mechanisms have eluded characterization for more than a century. The classical autonomic parasympathetic and sympathetic nervous systems are involved, but the process of erection does not appear to require cholinergic or adrenergic mechanisms. As the search for the principal mediator of penile erection has continued over time, nitric oxide (NO), a gaseous messenger molecule, has been rapidly advanced to fulfill this elusive role. In the recent past, various biochemical and functional data have accumulated to support this understanding. These have shown that NO is an important mediator of corpus cavernosal smooth muscle relaxation and have revealed its potential sources and mechanisms of action in the penis. Additional work involving animal erection models has established that NO mediates physiologic penile erection. This minireview presents these data and includes results from recent clinical trials that have preliminarily evaluated the efficacy of NO-generating or -releasing compounds for the treatment of erectile dysfunction.
Magnetic Resonance Imaging of Vascular Lesions in Children (1984)

Ten children aged 1 week to 13 years with 12 vascular abnormalities were examined with magnetic resonance imaging (MRI) and other imaging modalities. MRI was the only single non-invasive modality that demonstrated all lesions and their internal structures. The vascular nature of 3 hemangiomas could not be established with MRI alone. No marked differences in MRI appearance was seen in 5 cases with vascular tumors compared with 5 cases with other vascular abnormalities. The status of the blood in the vascular lesions as flowing fast, slow, or not at all was successfully assessed in 9 of the 12 lesions.
Smart mesoporous silica nanoparticles for controlled-release drug delivery (2015)

Abstract Stimuli-responsive controlled-release nanocarriers are promising vehicles for delivery of bioactive molecules that can minimize side effects and maximize efficiency. The release of the drug occurs when the nanocarrier is triggered by an internal or external stimulus. Mesoporous silica nanoparticles (MSN) can have drugs and bioactive cargos loaded into the high-capacity pores, and their release can be triggered by activation of a variety of stimulus-responsive molecular “gatekeepers” or “nanovalves.” In this mini-review, we discuss the basic concepts of MSN in targeted drug-release systems and cover different stimulus-responsive gatekeepers. Internal stimuli include redox, enzymes, and pH, while external stimuli include light, ultrasound, and magnetic fields, and temperature can either be internal or external.
An unusual Î²-ketoacyl:acyl carrier protein synthase and acyltransferase motifs in TaK, a putative protein required for biosynthesis of the antibiotic TA inMyxococcus xanthus (2001)

The antibiotic TA of Myxococcus xanthus is produced by a type-I polyketide synthase mechanism. Previous studies have indicated that TA genes are clustered within a 36-kb region. The chemical structure of TA indicates the need for several post-modification steps, which are introduced to form the final bioactive molecule. These include three C-methylations, an O-methylation and a specific hydroxylation. In this study, we describe the genetic analysis of taK, encoding a specific polyketide beta-ketoacyl:acyl carrier protein synthase, which contains an unusual beta-ketoacyl synthase and acyltransferase motifs and is likely to be involved in antibiotic TA post-modification. Functional analysis of this beta-ketoacyl:acyl carrier protein synthase by specific gene disruption suggests that it is essential for the production of an active TA molecule.