gebhart/patrepeval huggingface dataset:
Effect of Junction Point Functionality on the Lamellar Spacing of Symmetric (PS)n(PI)n Miktoarm Star Block Copolymers (2003)

To probe the effect of junction point functionality in miktoarm star block copolymer architecture on chain conformation and morphology, a series of AnBn miktoarm star copolymers where A arms are PS blocks and B arms are PI blocks were investigated. The overall series including a diblock and the star block copolymers can be represented by AnBn, where n = 1, 2, 4, and 16. These materials were produced by synthesizing a single batch of living PS arms and a single batch of living PI arms and then linking them together with chlorosilane coupling agents of different functionality. Thus, all PS arms are identical and all PI arms are identical across the entire series of materials. All stars in the series have equal numbers of PS and PI arms, and the volume fractions of all the samples in the series (nearly 0.50 PS by volume) are identical within experimental error. All the materials were found, via small-angle X-ray scattering and transmission electron microscopy, to form lamellar morphologies. A significant increase in lamellar spacing with increasing junction point functionality (n) was found in this series of materials and can be attributed to molecular crowding near the junction point.
Towards technically controlled bioreactor maturation of tissue-engineered heart valves (2022)

Bioreactors are important tools for the pre-conditioning of tissue-engineered heart valves. The current state of the art mostly provides for timed, physical and biochemical stimulation in the bioreactor systems according to standard protocols (SOP). However, this does not meet to the individual biological variability of living tissue-engineered constructs. To achieve this, it is necessary to implement (i) sensory systems that detect the actual status of the implant and (ii) controllable bioreactor systems that allow patient-individualized pre-conditioning. During the maturation process, a pulsatile transvalvular flow of culture medium is generated within the bioreactor. For the improvement of this conditioning procedure, the relationship between the mechanical and biochemical stimuli and the corresponding tissue response has to be analyzed by performing reproducible and comparable experiments. In this work, a technological framework for maturation experiments of tissue-engineered heart valves in a pulsating bioreactor is introduced. The aim is the development of a bioreactor system that allows for continuous control and documentation of the conditioning process to increase reproducibility and comparability of experiments. This includes hardware components, a communication structure and software including online user communication and supervision. Preliminary experiments were performed with a tissue-engineered heart valve to evaluate the function of the new system. The results of the experiment proof the adequacy of the setup. Consequently, the concept is an important step for further research towards controlled maturation of tissue-engineered heart valves. The integration of molecular and histological sensor systems will be the next important step towards a fully automated, self-controlled preconditioning system.
Adaptive Control of Robot Manipulators in Constrained Motion (1993)

Adaptive motion and force control of manipulators in constrained motion in the presence of parametric uncertainties both in the robot and contact surfaces is solved in this paper. A new constrained dynamic model is obtained to account for the effect of contact surface friction. An adaptive law is suggested with unknown parameters updated by both motion and force tracking errors to guarantee asymptotic motion and force tracking without any persistent excitation condition to be satisfied. The suggested controller includes a expected PI type force feedback control structure with a low proportional (P) force feedback gain. Acausality problem is analyzed by a quasi-static method to show that allowable proportional force feedback gain is severely limited in implementation. With a slight modification to the updating law, the controller also possesses robustness to bounded measurement noise and disturbances.
Bradykinin and B2 receptor antagonism in rat and human articular chondrocytes (2010)

BK mediated inflammatory changes and cartilage degradation and B₂ receptor blockade would, therefore, be a potential treatment for OA.
Recovery Time Dispersion Measured from 87‐Lead Body Surface Potential Mapping as a Predictor of Sustained Ventricular Tachycardia in Patients with Idiopathic Dilated Cardiomyopathy (2000)

The RTc-87 dispersion is a useful tool to identify subjects at risk for sustained VT in patients with idiopathic DCM.
Mechanism and synthetic utility of boron trifluoride etherate-promoted organolithium additions (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanism and synthetic utility of boron trifluoride etherate-promoted organolithium additionsMichael J. Eis, J. E. Wrobel, and Bruce GanemCite this: J. Am. Chem. Soc. 1984, 106, 12, 3693–3694Publication Date (Print):June 1, 1984Publication History Published online1 May 2002Published inissue 1 June 1984https://pubs.acs.org/doi/10.1021/ja00324a060https://doi.org/10.1021/ja00324a060research-articleACS PublicationsRequest reuse permissionsArticle Views4389Altmetric-Citations215LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High spectral efficient W-band OFDM-RoF system with direct-detection by two cascaded single-drive MZMs (2013)

W-band wireless transmission has attracted a lot of interest due to its wider available bandwidth (i.e. 75-110 GHz). In this article, we propose a direct-detection orthogonal frequency division multiplexing radio over fiber (OFDM-RoF) system via two cascaded single-drive MZMs at center frequency of 103 GHz. We discuss maximum bandwidth of different modulation formats under forward error correction (FEC) threshold (3.8 x 10(-3)). Up to 40-Gbps 16-QAM OFDM signals is achieved over 25-km fiber and 2-m wireless transmission. To overcome the penalty from uneven frequency response, bit-loading algorithm is applied to discuss data rate and spectral efficiency with signal bandwidth from 5 to 10 GHz. With 10-GHz bandwidth, 46.4-Gb/s data rate and 4.64-bit/s/Hz spectral efficiency was achieved. To achieve 40-Gbps data rate, the required bandwidth of OFDM signal with bit-loading is 2 GHz less than that without bit-loading.
CD200:CD200R-Mediated Regulation of Immunity (2012)

The type 1 membrane glycoprotein CD200, widely expressed on multiple cells/tissues, uses a structurally similar receptor (CD200R1), whose expression is more restricted to cells of the myeloid and lymphoid lineages, to transmit signals affecting responses in multiple physiological systems. Thus CD200 expression is reported to exert effects on cancer growth, autoimmune and allergic disorders, infection, transplantation, bone development and homeostasis, and reproductive biology. It was initially thought, based on the idea that CD200R1 was mostly expressed on cells of myeloid origin, that CD200:CD200R1 interactions were primarily dedicated to controlling myeloid cell function. However additional members of the CD200R family have now also been identified, although their function(s) remain unclear, and CD200R1 itself is now known to be expressed by subsets of T cells and other cells. Together these observations add layers of complexity to our understanding of CD200-related regulation. In common with a number of physiological systems, the mechanism(s) of CD200-induced signaling seem to fit within a similar framework of opposing actions of kinases and phosphatases. This paper highlights the advances in our knowledge of immunoregulation achieved following CD200:CD200R interaction and the potential clinical applicability of that information.
Triboluminescence spectroscopy of aromatic compounds (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTriboluminescence spectroscopy of aromatic compoundsGordon E. Hardy, James C. Baldwin, Jeffrey I. Zink, William C. Kaska, Po-Hsin Liu, and Lawrence DuboisCite this: J. Am. Chem. Soc. 1977, 99, 11, 3552–3558Publication Date (Print):May 1, 1977Publication History Published online1 May 2002Published inissue 1 May 1977https://pubs.acs.org/doi/10.1021/ja00453a002https://doi.org/10.1021/ja00453a002research-articleACS PublicationsRequest reuse permissionsArticle Views636Altmetric-Citations95LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
App-Based Saccade Latency and Directional Error Determination Across the Adult Age Spectrum (2021)

Our system and algorithms allow ubiquitous tracking of saccade latency and directional error rate, which opens up the possibility of quantifying patient state on a finer timescale in a broader population than previously possible.
The intramolecular nitrile oxide cycloaddition route to spirocyclic alkaloids. A total synthesis of isonitramine and sibirine (1985)

A. P. Kozikowski and P.-W. Yuen, J. Chem. Soc., Chem. Commun., 1985, 847 DOI: 10.1039/C39850000847
Selective Reduction of NO with Methane over Alumina-Supported Palladium Catalysts. (2000)

金属酸化物担持パラジウム触媒による,メタンを還元剤として用いたNO選択還元反応を行い,担体の種類やパラジウム担持量,調製条件などの影響について検討した。触媒活性は固定床流通反応装置を用いて測定した。アルミナ担体で他の金属種を担持させた触媒や,パラジウム担持で他の金属酸化物担体を用いた触媒と比較して,アルミナ担持パラジウム触媒はNO選択還元反応において特異的に高活性を示した。高温で還元·前処理を行ったアルミナ担持パラジウム触媒では,活性が低下した。キャラクタリゼーションの結果,アルミナ担体は特に固体酸性が高く,またパラジウム分散度も高くなった。同じアルミナ担体でも,高温で還元を行ったものは,パラジウム分散度が低くなった。これらの結果から,担体の固体酸性とバラジウム分散度が,触媒の活性に密接に関与していることがわかった。また反応経路は,パラジウム上でメタンが部分酸化され,その部分酸化物がアルミナ上でNOxと反応するという経路が考えられた。
Effect of Human Fibroblast Interferon on Normal Human Monocyte Activation Induced by a Factor Found in Sarcoidosis Sera (1987)

Abstract Effect of human fibroblast interferon (IFN‐β) on normal human monocyte activation induced by the monocyte activating factor found in sarcoidosis sera was studied. Spreading was used as one indicator of monocyte activation. IFN‐β was shown to inhibit spreading of normal human monocytes induced by the activating factor. The inhibitory activity of IFN‐β against monocyte spreading was adsorbed with monoclonal antibody to human IFN‐β‐Sepharose beads. Increases in phagocytosis and glucose consumption of normal human monocytes induced by the activating factor was also inhibited by IFN‐β. Recombinant IFN‐β also showed similar inhibitions.
Ultrahigh oxygen-scavenging norbornene copolymers bearing imidazolyl iron complexes for fabricating active and sustainable packaging films (2019)

A tough and transparent norbornene copolymer film affixing an imidazolyl iron-salen complex catalyst exhibited an ultra-high, humidity-independent, and monthly paced oxygen-scavenging capacity up to 300 mL (oxygen gas at STP)/g(film). The homogeneously dispersed and immobilized iron complex in the polymer matrix catalytically contributed to the exceptionally high-yield oxidative consumption of polymer allylic bonds.
Sensitizing immune unresponsive colorectal cancers to immune checkpoint inhibitors through MAVS overexpression (2022)

These data demonstrate that intratumoral MAVS expression results in local and systemic tumor antigen-specific T cell responses, which could be combined with PD-L1 ICI to permit effective anti-tumor immunotherapy in ICI resistant cancers.
Abstract 17117: In Vitro Monitoring of Microbubble Mediated Clot Dissolution Using Optical Coherence Tomography (OCT) (2011)

Background: Thrombolysis using ultrasound (US) induced destruction of systemically injected microbubbles (MBs) is a potential targeted treatment for acute myocardial infarction or ischemic stroke. The physical mechanisms underlying MB mediated clot lysis are incompletely elucidated, partly due to limitations in methods to characterize morphologic and volumetric changes in a thrombus resulting from MB destruction. Here, we explore possibilities for 3D quantitative assessment of sonothrombolysis using optical coherence tomography (OCT), a high resolution imaging modality. Methods: Thrombi were formed in polyethylene tubing (1.67 mm i.d.) from recalcified porcine blood using silk suture as a nidus for thrombosis. Lipid shell MBs suspended in saline and tissue plasminogen activator (rt-PA, 3 μ g/ml) were perfused through the tube (22 μ l/min, 2x107 MBs/ml) using a syringe pump while US pulses (1 MHz, 1.0 MPa, 100 cycles) were delivered over 30 min to the clot from a single element transducer every 5 sec to ensure MB replenishment between destructive pulses. 3D OCT images of clots were obtained before and after US treatment, rt-PA alone, or saline alone (n=3/condition). Clot volume was measured using clot boundary determination by thresholding pixel intensity of each cross-sectional OCT image. Results: Thrombi treated with US + MBs + rt-PA decreased in volume by 55.7% (0.02 mm3; p=0.02). rt-PA alone resulted in a 25.6% (0.009 mm3; p=0.39) decrease in volume and treatment with saline alone did not change clot volume (0.003 mm3; p=0.94). OCT images qualitatively showed greatest change in clot shape and volume in regions closest to the source of US (Fig 1). Conclusion: 3D OCT can quantify thrombolysis. As expected, the addition of US and MBs enhanced the lytic effect of rt-PA. OCT imaging may reveal the physical effects of contrast US on thrombus structure, thereby yielding insights into mechanisms of sonothrombolysis that can be used to optimize treatment regimens.
Direct observation of the tip shape in scanning probe microscopy (1993)

In this study we report on the first direct observation of the real shape of the atomic force microscopy (AFM) tip using the AFM technique itself, utilizing a specially designed sample geometry. This is the first report of the so-called inverse AFM mode in which the tip is actually used as the sample and vice versa. We propose how this method can, with a very high accuracy, be used for studying objects, e.g., biomolecules, that are attached to the usual AFM cantilever tip. Finally, we discuss how this method can significantly increase the reliability of the obtained AFM images.
Supramolecular Construction of Molecular Ladders in the Solid State (2003)

Stufen in der supramolekularen Chemie: Lineare Templatverbindungen wurden zum Formen von Polyenen im festen Zustand durch Wasserstoffbrückenbindungen eingesetzt. Die Polyene dimerisieren in einer [2+2]-Photocycloaddition quantitativ zu [3]- und [5]-Ladderanen (das Bild zeigt das so erhaltene [5]-Ladderan).
Application of SAND Technology in DASH-Enabled Content Delivery Networks and Server Environments (2018)

MPEG Dynamic Adaptive Streaming over HTTP (DASH) provides formats that are suitable to stream segmented media content over HTTP. DASH clients follow a client-pull paradigm by adapting their requests based on the available bandwidth and other local resources. This has proven to be easier to deploy over content delivery network infrastructure than server-push technologies. However, this decentralized nature introduces new challenges such as offering a consistent and higher quality of service for premium users. MPEG addresses this issue in the recently published MPEG-DASH part 5, Server and Network-Assisted DASH (SAND). The key features of SAND are asynchronous network-to-client and network-to-network communication of quality-related assisting information. This way, the quality of services can be improved by the DASH clients reacting realtime to the assistance and recommendation sent by the service provider. In addition, DASH-Industry Forum (DASH-IF) is further defining interoperable guidelines to optimize SAND deployments in a variety of environments: home network, over-the-top, and so on. DASH-IF is expected to publish this new interoperable guideline by the end of 2017.
Biselyngbyaside, a Macrolide Glycoside from the Marine Cyanobacterium Lyngbya sp. (2009)

Bioassay-guided fractionation of the cytotoxic constituents of the marine cyanobacterium Lyngbya sp. led to the isolation of biselyngbyaside (1), a new 18-membered macrolide glycoside. The structure of 1 was established by spectroscopic analysis including 2D-NMR techniques and by synthetic studies. Biselyngbyaside (1) exhibits broad-spectrum cytotoxicity in a human tumor cell line panel.
The endothelial border to health: Mechanistic evidence of the hyperglycemic culprit of inflammatory disease acceleration (2017)

The endothelial cell (EC) layer constitutes a barrier that controls movements of fluid, solutes and cells between blood and tissue. Further, the endothelial layer regulates vascular tone and directs local humoral and cellular inflammatory processes. The strategic position makes it an important player for maintenance of health and for development of a number of diseases. Endothelial dysfunction is known to be an important component of type 2 diabetes, but is also assumed to be involved in many other diseases, for example, rheumatoid arthritis, inflammatory bowel disease, asthma, and cardiovascular diseases. We here suggest that the EC plays a pivotal role in disease pathophysiology through initiation, potentiation, and maintenance of several inflammatory mechanisms. Our contention is based on the observation that hyperglycemia-intermittent or sustained, local or systemic-is a major culprit for several endothelial dysfunctions. There is also mounting epidemiological evidence that dietary intake of refined sugars is important for the development of a number of diseases beyond obesity and type 2 diabetes. Various diseases involving inflammatory and immunological components are accelerated by hyperglycemic events because the endothelium transduces "high glucose" signaling into significant pathophysiological phenomena leading to reduced endothelial barrier function, compromised vascular tone regulation and inflammation (e.g., cytokine secretion and RAGE activation). In addition, endothelial extracellular proteins form epitopes for potential specific antibody formation upon interactions with reducing sugars. This paper reviews the endothelial metabolism, biology, inflammatory processes, physical barrier functions, and summarizes evidence that although stochastic in nature, endothelial responses to hyperglycemia are major contributors to disease pathophysiology. We present molecular and mechanistic evidence that both biological and physical barriers, protein function, specific immunity, and inflammatory processes are compromised by hyperglycemic events and thus, hyperglycemic events alone should be considered risk factors for numerous human diseases. © 2017 IUBMB Life, 69(3):148-161, 2017.
The structure of the B subunit of calcineurin (1984)

The complete primary structure of the B subunit of calcineurin (protein phosphatase 2B) has been determined by automated sequence analysis. The protein consists of a single polypeptide chain of 168 residues, relative molecular mass 19200. The structure shows 35% identity with the sequence of calmodulin and 29% with troponin C. Homology is mainly confined to the regions of the four putative Ca2+-binding loops. The results demonstrate that the B subunit is a new member of this family of Ca2+-binding proteins. The N-terminal glycine residue is blocked with the C14-saturated fatty acid myristic acid and the first four residues are very similar to those of the catalytic subunit of cyclic-AMP-dependent protein kinase which also contains a myristoyl blocking group.
Evaluating the Expandability and Collapse Resistance of Expandable Tubulars (2009)

Abstract Expandable tubular technology is an effective method for saving on the costs of well drilling and completion. There are many applications for casing repair and slim hole casing design. The most essential performances of expandable tubular (EXP-T) are the expandability and collapse resistance, which are affected by not only the expanded pipe properties, but also the axial restraint caused by sticking pipe in well. This paper discusses the geometrical and material factors governing pipe expandability, the effect of axial restraint during the expansion, and the collapse resistance of the expanded pipe. Two types of pipe were evaluated using pipe expander equipped with a function of the axial restraint. FEA for pipe expansion considering the pipe geometries and the mechanical property were also carried out for solving the fracture mechanism and deriving the design diagram of EXP-T. In addition, the full-scale collapse tests were performed for evaluating the collapse resistance of the expanded pipes and verifying the prediction using the conventional formulas. These results reveal the relevant combination of the pipe geometries and the material properties for preventing the expansion failure. A potential to improve the collapse resistance of the pipe expanded under the axial restraint is drawn.
ChemInform Abstract: An Improved Procedure for the Generation and Selective Trapping of 2,4′‐Dilithiophenylethyne. (1987)

Abstract 2,4'‐Dilithiophenylethyne (III), prepared by treating of 4‐bromophenylethyne (I) with butyllithium (II), reacts selectively with the aldehyde (IV) to yield the carbinol (V), with DMF (VII) the ethynylbenzaldehyde (VI) is formed.
Data transmission scheme for enhancing effective downlink bandwidth in 5G mobile fronthaul with TDM-PON (2015)

For mobile fronthaul with TDM-PON, we propose a scheme that extends the downlink data transmittable time on mobile fronthaul. It can accommodate 32 antennas with single PON branch while satisfying the bandwidth requirement for radio transmission.
Timing of exercise therapy when initiating adjuvant chemotherapy for breast cancer: a randomized trial (2023)

There was no statistical difference in CRF improvement between concurrent vs. sequential exercise therapy relative to usual care in women with primary breast cancer. The promising tolerability and CRF benefit of ≈32 weeks of continuous exercise therapy warrant further evaluation in larger trials.
Record-brightness laser-diode bars for fiber coupling (2012)

High brightness, laser-diode bars are required for efficient coupling into small-core optical-fibers. Record power and brightness results were achieved using 20% fill-factor, 980nm, 1cm-wide, 4mm cavity-length bars. Lifetimes of single bars, operated CW at 200W and 20&deg;C, exceed 1000hr. Due to superb thermal management, the power conversion efficiency (PCE) exceeds 60% at 200W output power. Similar lifetime and PCE were obtained for a 3-bar stack emitting 600W output power.