gebhart/patrepeval huggingface dataset:
Polymorph-mediated antibody-dependent cytotoxicity—modulation of activity by drugs and immune interferon (1976)

Bovine polymorphonuclear leukocytes (PMN) mediated antibody-dependent cell cytotoxicity (ADCC) against erythrocyte and herpes virus-infected target cells. The extent of cytotoxicity was not affected by drugs that inhibited DNA, RNA, or protein synthesis. The effect did not occur in the absence of divalent cations, was suppressed by pretreatment of PMN with silica and cytochalasin B, and was subject to the bidirectional control by cyclic nucleotides; drugs decreasing cyclic AMP or elevating cyclic GMP levels enhanced ADCC. The ADCC phenomena was also enhanced by supernates containing immune interferon activity from antigen-stimulated-immune lymphocyte-macrophage cultures. The possibility that immune interferon(s) might be causing the elevation of ADCC and the relevance of this observation in terms of the part interferon might play in modulating recovery from herpes virus infections was discussed.
Inhibition of Lipid Droplet Accumulation in Macrophages by Triterpenoids Produced from Torametes orientaris (2005)

Four triterpenoids 1-4 isolated from the fruit body of Torametes orientaris were found to inhibit lipid droplet accumulation in macrophages. From the biochemical analysis, compounds 2 and 3 inhibited selectively cholesteryl ester synthesis in macrophages, while compounds 1 and 4 showed inhibition of both cholesteryl ester and triacylglycerol syntheses.
Electrical conduction and polarization of silica-based capacitors under electro-thermal poling. (2022)

Abstract not provided.
A digitally controlled 5GHz Analog Phase Interpolator with 10GHz LC PLL (2007)

International audience
Combinatorial Ricci Curvature and Laplacians for Image Processing (2009)

A new Combinatorial Ricci curvature and Laplacian operators for grayscale images are introduced and tested on 2D synthetic, natural and medical images. The effectiveness of the notions introduced herein, as compared with more classical methods, is shown by a variety of experimental results. Analogue formulae for voxels are also obtained. This novel approach is based upon more general concepts developed by R. Forman. Further applications, in particular a fitting Ricci flow, are discussed.
Molecular and phylogenetic analysis of a type K1 strain Trypanosoma evansi isolate from Nigerian cattle: An evaluation of the therapeutic effects of compounds from Brassica oleracea on the histopathology of infected wister rats (2023)

The K1 strain <i>T. evansi</i> was isolated from naturally infected cattle in this study. The results indicate that phenolic-rich compounds have anti trypanosoma activities capable of healing organ damage caused by trypanosomiasis.
Magnetic ordering in Cr-doped Bi 2 Se 3 thin films (2014)

We report the structural and magnetic study of Cr-doped Bi2Se3 thin films using x-ray diffraction (XRD), magnetometry and polarized neutron reflectometry (PNR). Epitaxial layers were grown on c-plane sapphire by molecular beam epitaxy in a two-step process. High-resolution XRD shows the exceptionally high crystalline quality of the doped films with no parasitic phases up to a Cr concentration of 12% (in % of the Bi sites occupied by substitutional Cr). The magnetic moment, measured by SQUID magnetometry, was found to be per Cr ion. The magnetic hysteresis curve shows an open loop with a coercive field of . The ferromagnetic transition temperature was determined to be analyzing the magnetization-temperature gradient. PNR shows the film to be homogeneously ferromagnetic with no enhanced magnetism near the surface or interface.
Efficient direct position determination of orthogonal frequency division multiplexing signals (2009)

The authors present an efficient method for positioning of orthogonal frequency division multiplexing (OFDM) signals. The method, called direct position determination (DPD), enables one to determine the emitter position in a single search operation. In formerly published articles on DPD, the signal was assumed to be a narrowband Gaussian source, which was subjected to a rather simple flat-fading channel model. Here, the authors extend the DPD algorithm to handle the OFDM signals that propagate through a frequency-selective channel, and derive the least squares estimator (LSE) for the problem. In addition, the authors present a method for a fine 2D position estimation, which enables one to reduce the DPD computational complexity without compromising on its estimation accuracy.
Structure–LCST relationships for end-functionalized water-soluble polymers: an “accelerated” approach to phase behaviour studies (2007)

A novel "high throughput" technique for LCST measurement was developed which is able to identify the effect of subtle changes in end group composition on the aqueous phase behaviour of water-soluble poly(2-(dimethylamino)ethyl methacrylate).
Targeting the Cholecystokinin Receptor: A Novel Approach for Treatment and Prevention of Hepatocellular Cancer (2020)

Hepatocellular carcinoma (HCC) is the fastest growing cancer worldwide in part due to the obesity epidemic and fatty liver disease, particularly nonalcoholic steatohepatitis (NASH). Chronic inflammation with the release of cytokines and chemokines with activation of hepatic stellate cells results in changes of the liver extracellular matrix (ECM) that predisposes to the development of HCC. Blood levels of the gastrointestinal peptide cholecystokinin (CCK) are increased in humans and mice consuming a high-fat diet. We found that the CCK-B receptor (CCK-BR) expression increased in the livers of mice with NASH. Treatment of mice with a CCK-BR antagonist, proglumide, prevented NASH, lowered hepatic inflammatory cytokines and chemokines, reduced oxidative stress, decreased F4/80<sup>+</sup> hepatic macrophages, and prevented HCC. CCK-AR and CCK-BR expression was increased in both murine and human HCC cell lines compared with that of normal liver, and CCK stimulated the growth of wild-type and CCK-A receptor knockout HCC cells <i>in vitro</i>, but not CCK-BR knockout cells suggesting that the CCK-BR mediates proliferation. Proglumide therapy significantly reduced growth by 70% and 73% in mice bearing Dt81Hepa1-6 or in RIL-75 HCC tumors, respectively. IHC of a human liver tissue array with a selective CCK-BR antibody revealed staining of human HCC and no staining in normal liver. PREVENTION RELEVANCE: This investigation demonstrates the role of the gastrointestinal peptide cholecystokinin (CCK) in hepatocellular carcinoma (HCC) and how CCK-BR blockade reverses the premalignant state of the hepatic extracellular matrix hence, rendering it less susceptible to the development of HCC. Thereby, CCK-BR blockade is a novel approach for the prevention/treatment of HCC.
Difference in Time to Locoregional Recurrence Between Patients With Right-Sided and Left-Sided Colon Cancers (2015)

Patients with right-sided colon cancers presented with significantly increased risk of locoregional recurrence. Right-sided location, female sex, T4 disease, lymph node metastasis, and perineural invasion are independent risk factors for locoregional recurrence of colon cancer.
Do photons push or pull a boundary? (2017)

Summary form only given. It is well known that photons carrying momentum ħk exert a positive pressure on an object in vacuum. However, whether photons push or pull an object immersed inside a dielectric medium is not so straightforward due to the century-old debate associated with the definition of photon momentum inside dielectrics [1-2]. This question becomes even more puzzling with the advent of metamaterials, which can have negative refractive indices and hence the momentum and energy flux can be in opposite directions, which seemingly indicates a photon tension in such a kind of material.To answer the question we consider a microscopic model. The macroscopic configuration is shown in Fig. 1(a), where an electromagnetic plane wave propagates across a boundary formed by two medium. We attempt to determine the light-induced stress at this boundary. To achieve this, we use a generic microscopic model as shown in Fig.1(b), where we assume the materials are formed by microscopic polarizable units (dipoles) arranged into a lattice, e.g. a square lattice here. In the long wavelength limit the lattice can be approximated as an effective medium characterized by the macroscopic effective permittivity (H ) and permeability ( P ). It is usually believed that the macroscopic parameters ( H,P ) are sufficient for calculating light-induced forces. We found that while the macroscopic parameters determine the total force, they do not give sufficient information to determine the force density. We first use the Maxwell stress tensor approach to calculate the optical force acting on each polarizable unit in the lattice. Then the boundary stress is obtained by summing the force acting all the units within the boundary region. We considered three kinds of lattices: square, triangle and amorphous lattice and found that they have different boundary stress [Fig. 1(c)-(e)], even though they are purposely designed to have the same effective permittivity and permeability and hence correspond to the same effective medium system. This means that the boundary stress is, in fact, indeterminate if only the macroscopic effective parameters are specified. Light can either push or pull a boundary, depending also on the microscopic lattice structure of the polarizable units that constitute the medium [3, 4].
Ferroelectric BaTiO3/SrTiO3 multilayered thin films for room-temperature tunable microwave elements (2013)

Ferroelectric BaTiO3/SrTiO3 with optimized c-axis-oriented multilayered thin films were epitaxially fabricated on (001) MgO substrates. The microstructural studies indicate that the in-plane interface relationships between the films as well as the substrate are determined to be (001)SrTiO3//(001)BaTiO3//(001)MgO and [100]SrTiO3//[100]BaTiO3//[100]MgO. The microwave (5 to 18 GHz) dielectric measurements reveal that the multilayered thin films have excellent dielectric properties with large dielectric constant, low dielectric loss, and high dielectric tunability, which suggests that the as-grown ferroelectric multilayered thin films can be developed for room-temperature tunable microwave elements and related device applications.
Blur and perceived depth (2011)

Estimating the three-dimensional (3D) structure of the environment is challenging because the third dimension – depth – is not directly available in the retinal images. This “inverse optics problem” has for years been a core area in vision science (Berkeley, 1709; Helmholtz, 1867). The traditional approach to studying depth perception defines “cues” – identifiable sources of depth information – that could in principle provide useful information. This approach can be summarized with a depth-cue taxonomy, a categorization of potential cues and the sort of depth information they provide (Palmer, 1999). The categorization is usually based on a geometric analysis of the relationship between scene properties and the retinal images they produce.
Anti-Stokes Raman lasers without inversion (1997)

We describe the propagation dynamics and gain line shape of pulsed, tunable, anti-Stokes Raman lasers without inversion. Analytical expressions for the gain are obtained and evaluated for inhomogeneously broadened atomic media. The inversionless gain, which requires selective pumping of one of two lower atomic states, occurs regardless of the relative populations of these states and vanishes when the atomic populations are in equilibrium.
Supplementary Figure 1 from Selective Inhibition of Histone Deacetylases Sensitizes Malignant Cells to Death Receptor Ligands (2023)

Supplementary Figure 1 from Selective Inhibition of Histone Deacetylases Sensitizes Malignant Cells to Death Receptor Ligands
Supplementary Figure Legend from Collaboration of Kras and Androgen Receptor Signaling Stimulates EZH2 Expression and Tumor-Propagating Cells in Prostate Cancer (2023)

&lt;p&gt;PDF file, 28K.&lt;/p&gt;
Terahertz plasmonic composites (2007)

The dielectric response of a polymer matrix composite can be substantially modified and tuned within a broad frequency band by integrating within the material an artificial plasmon medium composed of periodically distributed, very thin, electrically conducting wires. In the microwave regime, such plasmon/polymer composites have been studied analytically, computationally, and experimentally. This work reports the design, fabrication, and characterization of similar composites for operation at terahertz frequencies. Such composites require significant reduction in the thickness and spacing of the wires. We used numerical modeling to design artificial effective plasmonic media with turn-on frequencies in the terahertz range. Prototype samples were produced by lithographically embedding very thin gold strips into a PDMS [poly(dimethylsiloxane)] matrix. These samples were characterized with a Fourier-transform infrared interferometer using the frequency-dependent transmission and Kramers-Kronig relations to determine the electromagnetic properties. We report the characterization results for a sample, demonstrating excellent agreement between theory, computer design, and experiment. To our knowledge this is the first demonstration of the possibility of creating composites with tuned dielectric response at terahertz frequencies.
Hormonal Regulation of Immunoglobulins in the Rat Uterus: Uterine Response to Multiple Estradiol Treatments* (1984)

The present studies explored the processes by which estradiol regulates the accumulation or immunoglobulins A (IgA) and G (IgG) in the uterus. Levels of IgG in uterine secretions increased rapidly within 3 h after either two or three daily estradiol (1 microgram) treatments of ovariectomized rats and then declined. These levels, however, were only a small fraction of the total IgG content measured in uterine tissue. In contrast, luminal IgA levels increased gradually, with maximal amounts occurring 6 to 25 h after the third estrogen injection. Moreover, concentrations of IgA in uterine secretions at this time were significantly greater than those found in uterine tissue. Therefore, under the influence of estradiol, IgA moves from tissue to lumen against an apparent concentration gradient, whereas IgG movement is consistently down a gradient. Estradiol also rapidly increased the levels of IgA and IgG in uterine tissue. These increases, in contrast to the luminal pattern, occurred in parallel. Tissue content of both IgA and IgG were highest within 6 h after the second or third estradiol injection and then decreased. Of particular interest was our finding that, whereas the form of IgA in uterine tissue was both monomeric and polymeric, only polymeric IgA accumulated in the uterine lumen. Analysis of the effect of nafoxidine on the uterine Ig response indicated that this compound significantly increased the amount of uterine tissue IgA and IgG. The Ig levels in uterine secretions, however, were significantly less than those measured after estradiol treatment. Nafoxidine's stimulatory effect on luminal Ig concentrations was equal to that of estradiol when uteri were ligated to prevent fluid loss through the cervix. Utilization of this ligation procedure was also instrumental in demonstrating that chronic estrogen exposure (8 days) resulted in greater quantities of uterine luminal Ig. The role of T cells in the estrogen control of uterine luminal Igs was also examined. In rats that had been neonatally thymectomized, luminal levels of both IgA and IgG were significantly reduced, when compared to those measured in sham-operated or intact estrogen-treated controls. Thymic absence, however, did not prevent the estradiol-induced movement of IgA from tissue to lumen against a concentration gradient.
<I>Rubus sanctus</I> protects against carbon tetrachloride-induced toxicity in rat isolated hepatocytes: isolation and characterization of its galloylated flavonoids (2009)

In conclusion, RE protects against CCl(4)-induced toxicity in isolated rat hepatocytes.
Characteristics of Multiple Primary Malignancies in Renal Cell Carcinoma (2006)

Purpose: This study aimed to evaluate the incidence, nature and prognosis of multiple primary malignancies in renal cell carcinoma.\n\nMaterials and Methods: From June 1995 to April 2004, we retrospectively reviewed the records of 578 patients who underwent an operation for renal cell carcinoma at Yonsei University. The incidence of other primary malignancies, in addition to the renal cell carcinoma, was determined and classified as antecedent, synchronous or metachronous. We analyzed the influence of the other primary malignancies on the prognosis, and the overall survival rates of the patients with multiple primary malignancies were compared to the remaining patients.\n\nResults: Of the 578 patients, 62 patients (10.7%) had at least one malignancy beside renal cell carcinoma. In these cases, renal cell carcinoma was commonly incidental, small or low stage (75.8%). 22 patients (35.4%) had gastrointestinal cancer and 11 patients (17.7%) had hepatobiliary cancer. The malignancies were antecedent in 25 (40.3%), synchronous in 24 (38.1%), and metachronous in 14 patients (22.2%). On the analysis of overall survival with using the log rank test, there was no statistically significant factor for the presence of other antecedent or synchronous malignancies.\n\nConclusions: Primary malignancy associated with renal cell carcinoma in the Korean population shows a different pattern from that of Western countries. The expected survival rate of patients suffering from renal cell carcinoma with tumor involvement of other organs, if surgically treated, is similar to that of renal cell carcinoma alone, so aggressive surgical treatment of renal cell carcinoma should be performed.
Provably convergent coordinate descent in statistical tomographic reconstruction (2002)

Statistical tomographic reconstruction algorithms generally require the efficient optimization of a functional. An algorithm known as iterative coordinate descent with Newton-Raphson updates (ICD/NR) has been shown to be much more computationally efficient than indirect optimization approaches based on the EM algorithm. However, while the ICD/NR algorithm has experimentally been shown to converge stably, no theoretical proof of convergence is known. We prove that a modified algorithm, which we call ICD functional substitution (ICD/FS), has guaranteed global convergence in addition to the computational efficiency of the ICD/NR. The ICD/FS method works by approximating the log likelihood at each pixel by an alternative quadratic functional. Experimental results show that the convergence speed of the globally convergent algorithm is nearly identical to that of ICD/NR.
Tris(pyrrolyl-α-methyl)amines that Sterically Protect a Trigonal Metal Site (2007)

Three substituted tris(pyrrolyl-alpha-methyl)amines (H(3)[Aryl(3)TPA]) (Aryl = 2,4,6-C(6)H(2)Me(3), 2,4,6-C(6)H(2)(i-Pr)(3) (Trip), or 3,5-C(6)H(3)(CF(3))(2)) have been prepared. An X-ray study of [Trip(3)TPA]MoCl shows it to be a distorted trigonal bipyramidal species in which the 2,4,6-triisopropylphenyl substituents surround and protect the apical chloride. Attempts to prepare other Mo, Zr, and Hf complexes yielded species in which one pyrrole-containing arm remained free (Mo) or dimethylamine remained in the coordination sphere of [Aryl(3)TPA](3-) complexes (Zr, Hf).
Multiple Incidence Angle SIR-B Expenment Over Argentina: Stereo-Radargrammetrc Analysis (1986)

Four overlapping SIR-B radar images were obtained across southern Argentina; these form a total of six stereo models with intersection angles ranging from 5° to 23°. This data set is uniquely suited for experimental evaluation of some basic assumptions on stereo -radargrammetry. Each stereo model was measured on a specially programmed photogrammetric analytical plotter; the resulting coordinates of ground points were compared with those from maps. It is concluded that accuracies are lower than expected at the larger stereointersection angles, amounting to about ±60 m in each coordinate direction. This might be explained by limitations of the quality of stereofusion caused by look angle differences and specular point migration, backscatter differences due to different incidence angles, differences in azimuth directions, and image noise and speckle.
The complete nucleotide sequence of the I-Eαdimmune response gene (1983)

We have isolated and sequenced the complete murine I-E alpha immune response gene of the H-2db haplotype. The I-E alpha d gene consists of 5300 basepairs and is organized into five or possibly six exons that correspond to different domains of the alpha chain. The amino acid sequence deduced from the I-E alpha gene shows 75% homology to its human counterpart, the HLA-DR alpha chain. The absence of I-E antigen in H-2 mice is due to lack of E alpha chain synthesis. We show here that this defect is caused by a deletion in the 5' end of the I-E alpha b gene.
Characteristics of Zirconium Oxide Gate Ion-Sensitive Field-Effect Transistors (2007)

In this study, the zirconium oxide (ZrO2) membrane has been successfully applied as a pH-sensitive layer for ion-sensitive field-effect transistors (ISFETs). It exhibited an excellent response range of 56.7–58.3 mV/pH from the fixed current measurement using HP4156A. The ZrO2 membrane prepared by direct current (DC) sputtering was used as a pH-sensitive film that showed good surface adsorption with oxide and silicon. The pH sensitivities slightly decreased in 1 M NaCl solution; however, the device showed a perfect linear response of 52.5 mV/pH. The linear pH sensitivity response was measured between pH 1 to 13 in a buffer solution that was provided by Riedel–deHän.
KEY DETERMINANTS OF THE INTESTINAL MICROBIOTA IN EARLY CHILDHOOD (2017)

The intestinal microbiota develops rapidly after birth, determined by the maternal microbiota, mode of delivery, early infant feeding patterns and the subsequent long-term diet. While short-term dietary changes are associated with rapid effects on the intestinal microbiota, changes are transient and modest in magnitude. A healthy intestinal microbiota with high diversity can support a balanced immune homeostasis, allowing appropriate tolerance responses while simultaneously protecting against harmful exposures. Disruption of the intestinal microbiota in early life leads to a degraded stable microbiota that has been associated with increased risk of disease, particularly chronic non-communicable diseases that have increased in prevalence alongside progressive industrialisation. Strategies that support the establishment of a healthy microbiota in the first years of life and beyond may offer an approach to the prevention of chronic non-communicable diseases.
Photoinitiated grafting of porous polymer monoliths and thermoplastic polymers for microfluidic devices (2023)

A microfluidic device preferably made of a thermoplastic polymer that includes a channel or a multiplicity of channels whose surfaces are modified by photografting. The device further includes a porous polymer monolith prepared via UV initiated polymerization within the channel, and functionalization of the pore surface of the monolith using photografting. Processes for making such surface modifications of thermoplastic polymers and porous polymer monoliths are set forth.