gebhart/patrepeval huggingface dataset:
Frailty and Early Hospital Readmission After Kidney Transplantation (2013)

Early hospital readmission (EHR) after kidney transplantation (KT) is associated with increased morbidity and higher costs. Registry-based recipient, transplant and center-level predictors of EHR are limited, and novel predictors are needed. We hypothesized that frailty, a measure of physiologic reserve initially described and validated in geriatrics and recently associated with early KT outcomes, might serve as a novel, independent predictor of EHR in KT recipients of all ages. We measured frailty in 383 KT recipients at Johns Hopkins Hospital. EHR was ascertained from medical records as ≥1 hospitalization within 30 days of initial post-KT discharge. Frail KT recipients were much more likely to experience EHR (45.8% vs. 28.0%, p = 0.005), regardless of age. After adjusting for previously described registry-based risk factors, frailty independently predicted 61% higher risk of EHR (adjusted RR = 1.61, 95% CI: 1.18-2.19, p = 0.002). In addition, frailty improved EHR risk prediction by improving the area under the receiver operating characteristic curve (p = 0.01) as well as the net reclassification index (p = 0.04). Identifying frail KT recipients for targeted outpatient monitoring and intervention may reduce EHR rates.
Extending REBEKAH-IP with central port allocations for un-ambiguous IPv4 address expansion (2004)

In recent times, the imminent lack of public IPv4 addresses has attracted the attention of both the research community and the industry. The problem becomes even more pressing with the introduction of third generation (3G) cellular networks which are predicted to introduce hundred of millions of new IP capable terminals over the next few years. The cellular industry has decided to combat this problem by using IPv6 for the new terminals, but unfortunately since the vast majority of services will reside in the IPv4 address space the problem will remain for the foreseeable future. There have been many proposals on how to address the issue by extending the IPv4 address space so that the introduction of IPv6 is given more time for a smooth transition. One of these proposals, REBEKAH-IP is promising in that it is scalable and does not limit the services that can be supported. However, the scheme is limited in that there is a possibility for call blocking as the system gets loaded. In this paper, we introduce an improvement to REBEKAH-IP in which this side effect is removed, creating a robust and fully scalable system.
Abstract IA02: A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer. (2014)

Abstract Small cell lung carcinoma (SCLC) is highly aggressive and metastatic neuroendocrine lung cancer with a dismal 5-year survival. While a majority of patients is initially responsive to chemotherapy, chemoresistant tumors rapidly recur. There are no approved targeted therapies for SCLC. We used a systematic drug-repurposing computational approach querying a large number of gene expression datasets to identify new candidate FDA-approved drugs that may be used to treat SCLC. This analysis identified tricyclic antidepressants (TCAs) and related molecules as possible inhibitors of SCLC. Indeed, these compounds potently induce apoptotic cell death in chemonaïve and chemoresistant tumor cells in culture, in a genetically engineered mouse model, and in human SCLC tumor cells transplanted into immunocompromised mice. Imipramine and Promethazine, the two top candidate drugs, activate stress pathways and induce apoptosis and necrosis in SCLC cells, in part by blocking autocrine survival signals involving neurotransmitters and their receptors (GPCRs). The candidate drugs inhibit the expansion of other neuroendocrine tumors, including pancreatic neuroendocrine tumors. These experiments underscore the power of bioinformatics-based drug-repositioning approaches to rapidly repurpose FDA-approved drugs and identify a novel class of candidate molecules to treat patients with SCLC. In addition, our experiments highlight the importance of autocrine mechanisms promoting the growth of neuroendocrine tumor cells. Citation Format: Nadine Jahchan, Dudley Joel, Pawel Mazur, Joel Neal, Purvesh Khatri, Atul Butte, Julien Sage. A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer. [abstract]. In: Proceedings of the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer; 2014 Jan 6-9; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2014;20(2Suppl):Abstract nr IA02.
[Identification of candidates for multisite pacing: results and presumed mechanisms of action after five years experience]. (2006)

Biventricular resynchronisation is an additional therapeutic option in the management of refractory heart failure, with a functional and haemodynamic benefit as well as an improved morbidity and mortality. However, the rate of non-responsive patients has prompted a re-think about the presumed mechanisms of action for this procedure. This study aims to identify candidates more successfully. Based on five years experience in this centre, our work confirmed a medium and long term clinical benefit with multisite pacing. Nevertheless, there was evidence of a relative discordance between the functional benefit and the haemodynamic impact in terms of ejection fraction achieved with resynchronisation. While QRS narrowing appears to be a predictive factor for a successful procedure, the ECG alone is not sufficient to select 'unsynchronised' candidates. Statistical analysis reveals that before implantation the independent predictive factors to identify non-responsive patients include the presence of a complication of myocardial infarction and a low grade mitral leak. The limits of the ECG suggest a more mechanical than electrical approach to understanding the mechanisms of action for resynchronisation. Its effectiveness in cases of right bundle branch block confirm the hypothesis of left intra-ventricular conduction defects, not apparent on the surface ECG but accessible through new imaging techniques. Based on the hypothesis of delayed movement of the ventricular walls, the principle of resynchronisation aims to restore homogenous contraction. Echocardiography allows observation of electromechanical delay and opens new perspectives in the future for selecting patients for pacing. Ar
Integrating Core Data and Wireline Geochemical Data for Formation Evaluation and Characterization of Shale Gas Reservoirs (2010)

Abstract When core data, such as mineralogy, porosity, total organic carbon, and elastic properties, are available from a large multiwell database, it is possible to extract meaningful statistical relationships between the data. These relationships can then be applied in other wells with limited or no core data. X-ray diffraction (XRD) mineralogical data is unique in that it can readily be transformed to synthetic wireline geochemical elemental data, such as the weight fractions, aluminum, silicon, and calcium. This transformation establishes a relationship between the mineralogical data and the synthetic wireline geochemical data, which can be applied to "real wireline" geochemical data to select an appropriate set of minerals for prediction from the wireline geochemical data. Statistical optimization based approaches are generally used to perform this prediction of mineralogy from wireline data. The most difficult aspect of predicting mineralogy from wireline geochemical data is the selection of the proper mineral model. The proposed approach assists the analyst in the selection of the proper model. In addition, this paper shows how core XRD mineralogical data can be used to establish constraints between the predicted mineralogy, such as percent clay fraction illite greater than 60%. An accurate prediction of mineralogy from wireline geochemical data can be transformed to an accurate prediction of grain density, enabling an accurate prediction of total porosity (corrected for kerogen effects). The workflow described in this paper provides an effective approach for establishing and predicting mineralogy, grain density, and porosity from wireline geochemical data. This paper presents results for a Haynesville shale example. Finally, the proposed approach helps to maximize the value of the core data for shale gas plays.
BCL-Xl AUGMENTS T CELL SURVIVAL IN THE ABSENCE OF COSTIMULATION AND BLOCKS IMMUNOSUPPRESSION WITH CTLA4IG. (1998)

2 Bcl-xL, a member of the bcl-2 family of cell survival genes, is induced by T cell activation, and induction is prolonged and enhanced by CD28 costimulation. To study the role of bcl-xL induction in T cell survival, and in the events collectively known as costimulation, we used mice transgenic for Bcl-xL expressed on the T cell lineage (Grillot et al., J Exp Med, 183:381). Transgene-negative littermates served as controls. In vitro experiments were performed by stimulating unfractionated lymph node cells with anti-CD3 mAb. Proliferation was measured by labeling cells with the fluorescent dye CFSE and following fluorescence loss by flow cytometry (Wells et al., J Clin Invest, 100:3173), and viability was assessed simultaneously by exclusion of the vital dye TOPRO-3. In the presence of control Ig, both wild-type and Bcl-xL T cells exhibited a similar cell survival rate of 20-50%, with the highest levels of survival occurring in cells which had undergone the most rounds of mitosis. Unexpectedly, when CTLA4Ig was added to the cultures, cell survival was not affected in wild type cells, but was markedly increased to 70-90% in Bcl-xL T cells, an effect which was particularly marked in the CD8 subpopulation. These results suggested that Bcl-xL expression might provide a selective survival advantage in the absence of CD28/CTLA4 mediated signals, perhaps blocking Fas mediated cell death. This effect would not be observed in the absence of CTLA4Ig, in which case negative signals through CTLA4 itself could result in bcl-xL “resistant” cell death. To determine if improved surival of Bcl-xL T cells in absence of CD28/CTLA4 signals might affect the ability to immunosuppress these mice with CTLA4Ig we examined two immune response: contact hypersensitivity (CHS) and cardiac allograft rejection. While CTLA4Ig blocked CHS by 50-60% in wild type mice (p<0.01 compared with control Ig), it had no effect in Bcl-xL mice (n=5 mice per group). Similarly, neither CTLA4Ig nor anti-CD40L mAb could prolong cardiac allograft survival in Bcl-xL mice (median survival time 28 days), while either agent led to prolonged survival in wild-type mice (median survival >100 days). Together, these data suggest that induction of cell death by blocking induction of Bcl-xL is an important component of CTLA4Ig-mediated immunosuppression.
Modeling chemically amplified resists for 193-nm lithography (2000)

Post exposure bake (PEB) models in the STORM program have been extended to study pattern formation in 193 nm chemically amplified resists. Applications to resists formulated with cycloolefin-maleic anhydride copolymers, cholate based dissolution inhibitor, nonaflate photoacid generator and base quencher are presented. The PEB modeling is based on the chemical and physical mechanisms including the thermally induced deprotection reaction, acid loss due to base neutralization and protected-sites-enhanced acid diffusion. Simplifying assumptions are made to derive analytical expressions for PEB. The model parameters are extracted from the following experiments. UV-visible spectroscopy is used to extract the resist absorbance parameters. The generation of acid is monitored using the method of 'base additions.' The extent of deprotection that occurs during the bake is determined by monitoring the characteristic FTIR absorbance band around 1170 cm<SUP>-1</SUP> over a range of exposure doses and bake temperatures. Diffusion parameters are extracted from line end shortening (LES) measurements. These parameters are optimized using the Method of Feasible Directions algorithm. Application results show good agreement with experimental data for different LES features.
Real-time discrete multi-tone transmission for passive optical networks in Cand O-band (2019)

DMT at 25 Gbit/s, 50 Gbit/s and 100 Gbit/s in passive systems with electro-absorption modulators is investigated. Transmission in C- and O-band are compared, yielding up to 22 km reach, 100 Gbit/s in O-band. All results are obtained with a real-time signal processing ASIC.
In Vitro Dissolution Behavior of Custom Made CaP Scaffolds for Bone Tissue Engineering (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Severe bleeding tendency caused by a rare complication of excessive fibrinolysis with disseminated intravascular coagulation in a 51-year-old Japanese man with prostate cancer: a case report (2012)

This patient with rare complications of disseminated intravascular coagulation and excessive fibrinolysis is a warning case of potential coagulation disorder onset in patients with prostate cancer. We propose that combined administration of tranexamic acid and low-molecular-weight heparin together with high-dose anti-androgen therapy is a useful therapeutic option for patients with this complicated coagulation disorder.
Generalized transmission ellipsometry for twisted biaxial dielectric media: application to chiral liquid crystals (1996)

We report on the application, for the first time to our knowledge, of spectroscopic generalized ellipsometry to liquid crystal materials. We have measured the three normalized elements of the Jones transmission matrix t at various sample temperatures within the spectral range from 340 to 1700 nm (0.73 to 3.65 eV) on thin cells filled with twisted nematic mixtures 4-cyano-4′-pentylbiphenyl (5CB) and 4-cyano-4′-(2 methyl)-butylbiphenyl (CB15) (Ref. 4). The Berreman 4 × 4 matrix for electromagnetic plane waves in a biaxial medium homogeneously twisted along the sample normal is derived and presented. Analytic expressions in the case of light propagation along the helical axis permit the calculation of the transmission and reflection coefficients simultaneously without numerical approximations. This solution is valid for any biaxial configuration of chiral liquid crystals, including the case of absorption. We have fully analyzed the measured Jones transmission matrix elements and obtained the geometrical sample properties and, as a function of the photon energy and the temperature, the refractive indices no, and ne of the chiral liquid crystals. We found that within the experimental error the main refractive indices of the mixtures 5CB and CB15 are those of pure 5CB at the same reduced temperatures. The handedness of the optical activity of the samples can be obtained immediately from the phase information of the Jones transmission matrix coefficients.
ChemInform Abstract: Synthesis of Chiral Dendrimers with a Hydrocarbon Backbone and Application to the Catalytic Enantioselective Addition of Dialkylzincs to Aldehydes. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The sum-absolute-difference motion estimation accelerator (2002)

We investigate the Sum Absolute Difference (SAD) operation, an operation frequently used by a number of algorithms for digital motion estimation. For such operation, we propose a single vector instruction that can be performed (in hardware) on an entire block of data in parallel. We investigate possible implementations for such an instruction. Assuming a machine cycle comparable to the cycle of a two cycle multiply, we show that for a block of 16/spl times/1 or 16/spl times/16, the SAD operation can be performed in 3 or 4 machine cycles respectively. The proposed implementation operates as follows. First we determine in parallel which of the operands is the smallest in a pair of operands. Second we compute the absolute value of the difference of each pairs by subtracting the smallest value from the largest and finally we compute the accumulation. The operations associated with the second and the third step are performed in parallel resulting in a multiply (accumulate) type of operation. Our approach covers also the Mean Absolute Difference (MAD) operation at the exclusion of a shifting (division) operation.
Toward a Digital Ecosystem: International Symposium on Ubiquitous Virtual Reality 2010 (2011)

The International Symposium on Ubiquitous Virtual Reality (ISUVR) series continues to provide an interdisciplinary forum for leading researchers and graduate students, especially in the areas of ubiquitous computing, virtual reality, and augmented reality. The 2010 symposium's theme, "Toward a Digital Ecosystem," emphasized the roles of end users in actively creating and maintaining content in a managed systematic way, referred to as the digital ecosystem.
Abstract 11143: Anatomy of the Coronary Sinus and the Epicardial Coronary Venous System at Autopsy: A Perspective for Electrophysiologists (2011)

Introduction: Cannulation of the coronary sinus (CS) is routinely required for electrophysiological studies and placing left ventricular (LV) leads. Understanding the anatomy of the coronary venous...
Semiconductor lasers : Physics and applications (1997)

Contains an introduction and reports on eight research projects.
THE THERAPEUTIC EFFECT OF 16 ANTIMICROBIAL AGENTS ON CRYPTOSPORIDIUM INFECTION IN MICE (1982)

The therapeutic efficiency of 16 anti-microbial agents (Ethopabate, Nicarbazin, Sulphaquinoxaline, Furaltadone, Enterolyte-N, Sulphamethazine, Trinamide, Amprol, Phenamidine, Zoaquin, Halofuginone, Salinomycin, Monensin, Emtryl, Arprinocid and Amprolium) were examined against Cryptosporidium infections in mice. The Cryptosporidium was originally isolated from a field outbreak of calf diarrhoea. The drugs neither prevented nor modified the course of the infection as compared with infected, untreated mice.
Innovative Practices Track: New Methods for System Level Test of Image Projection and Radar VLSI Systems (2022)

OverviewThere are two presentations in this session which describe non-conventional test methods. The first presentation is about testing micro-mirror devices used for imaging and light projection applications. The second presentation is about new directions in testing radar devices. Together they highlight new challenges in testing these systems in the context of the applications that they are incorporated into.
Intranasal immunization using biphasic lipid vesicles as delivery systems for OmlA bacterial protein antigen and CpG oligonucleotides adjuvant in a mouse model (2005)

The nasal mucosa is an important arm of the mucosal system since it is often the first point of contact for inhaled antigens. The ineffectiveness of the simple delivery of soluble antigens to mucosal membranes for immunization has stimulated extensive studies in appropriate delivery systems and adjuvants. We have evaluated biphasic lipid vesicles as a novel intranasal (i.n.) delivery system (designated as vaccine targeting adjuvant, VTA) containing bacterial antigens and CpG oligodeoxynucleotides (ODNs). Results show that administration of antigen and CpG ODNs in biphasic lipid vesicles resulted in greater induction of IgA levels in serum (P< 0.05) and mucosal antibody responses such as IgA in nasal secretions and lung (P< 0.01) after immunization with a combined subcutaneous (s.c.)/i.n. as compared to s.c./s.c. approach. Based on antibody responses, VTA formulations were found to be suitable as delivery systems for antigens and CpG ODNs by the intranasal route, resulting in a Th2-type of immune response, characterized by IgG1 and IL-4 production at the systemic level.
Biodegradable harmonophores for targeted high-resolution in vivo tumor imaging (2019)

Abstract Optical imaging probes have played a major role in detecting and monitoring of a variety of diseases 1 . In particular, nonlinear optical imaging probes, such as second harmonic generating (SHG) nanoprobes, hold great promise as clinical contrast agents, as they can be imaged with little background signal and unmatched long-term photostability 2 . As their chemical composition often includes transition metals, the use of inorganic SHG nanoprobes can raise long-term health concerns. Ideally, contrast agents for biomedical applications should be degraded in vivo without any long-term toxicological consequences to the organism. Here, we developed biodegradable harmonophores (bioharmonophores) that consist of polymer-encapsulated, self-assembling peptides that generate a strong SHG signal. When functionalized with tumor cell surface markers, these reporters can target single cancer cells with high detection sensitivity in zebrafish embryos in vivo . Thus, bioharmonophores will enable an innovative approach to cancer treatment using targeted high-resolution optical imaging for diagnostics and therapy.
Conformation of Membrane-associated Proapoptotic tBid (2004)

The proapoptotic Bcl-2 family protein Bid is cleaved by caspase-8 to release the C-terminal fragment tBid, which translocates to the outer mitochondrial membrane and induces massive cytochrome c release and cell death. In this study, we have characterized the conformation of tBid in lipid membrane environments, using NMR and CD spectroscopy with lipid micelle and lipid bilayer samples. In micelles, tBid adopts a unique helical conformation, and the solution NMR (1)H/(15)N HSQC spectra have a single well resolved resonance for each of the protein amide sites. In lipid bilayers, tBid associates with the membrane with its helices parallel to the membrane surface and without trans-membrane helix insertion, and the solid-state NMR (1)H/(15)N polarization inversion with spin exchange at the magic angle spectrum has all of the amide resonances centered at (15)N chemical shift (70-90 ppm) and (1)H-(15)N dipolar coupling (0-5 kHz) frequencies associated with NH bonds parallel to the bilayer surface, with no intensity at frequencies associated with NH bonds in trans-membrane helices. Thus, the cytotoxic activity of tBid at mitochondria may be similar to that observed for antibiotic polypeptides, which bind to the surface of bacterial membranes as amphipathic helices and destabilize the bilayer structure, promoting the leakage of cell contents.