gebhart/patrepeval huggingface dataset:
The Difficulty of Indicating Transformation: The Challenge for Library Statistics and Surveys (2014)

Academic libraries have long refined the tools and skills in order to show their positive impact to research, to science and to the overall society. The aim is to provide essential information for library managers and decision makers. However, the qualitative and quantitative analyses showing libraries’ impact should also provide indications about change, i.e. the transformation of such social practices that challenge the essence of libraries. This paper presents two sources of information for analysing libraries’ impact on the national level. The first is the Finnish Research Library Statistics Database and the second is the National Library End-User Survey of Finnish Libraries. The Database includes the annual statistics of all Finnish higher education institution libraries and also several special libraries. The End-User Survey is an online questionnaire aimed at the customers of all library sectors. These sources of information have been collected for several years and they can therefore reveal changes in time. They have been adjusted to the changing information needs and the transforming functions of libraries. Still, the society seems to transfer faster than these mechanisms can capture. This paper discusses reasons why the transformation of social practices may be out of the reach of traditional information sources for analysing libraries’ impact. There are methodological issues to be considered. Furthermore, the paper examines the newly-published ISO 16439 standard on impact evaluation. The aim is to discuss how the standard comports with the recent practices of national-level data collection. The paper ends with discussion on complementary information sources which can be useful in tracing societal transformation.
Cable-suspended planar parallel robots with redundant cables: controllers with positive cable tensions (2004)

Cable-suspended robots are structurally similar to parallel actuated robots but with the fundamental difference that cables can only pull the end-effector but not push it. From a scientific point of view, this feature makes feedback control of cable-suspended robots lot more challenging than their counterpart parallel-actuated robots. In the case with redundant cables, feedback control laws can be designed to make all tensions positive while attaining desired control performance. This paper describes these approaches and their effectiveness is demonstrated through simulations of a three degree-of-freedom cable suspended robots with four, five, and six cables.
Controlled and deterministic creation of synthetic antiferromagnetic domains by focused ion beam irradiation (2021)

We study layered synthetic antiferromagnets (SAFs) with out-of-plane interface anisotropy, where the layer-wise antiferromagnetic (AF) alignment is induced by interlayer exchange coupling (IEC). By applying low energy He+ focused ion beam irradiation to the SAF, a depth-dependent reduction of the IEC and anisotropy can be achieved due to layer intermixing. As a consequence, after irradiation, a specific field reversal sequence of the SAF is energetically preferred. When tuning the pristine SAF to exhibit an inverted field reversal, we are thus able to create AF domains in the irradiated regions. When irradiated with a fluence gradient, these AF domains can be further deterministically manipulated by an external magnetic field. Among other applications, this could be utilized for engineering a controllable and local magnetic stray field landscape, for example, at AF domain walls, within the otherwise stray field free environment provided by the SAF.
Single‐Layer Semiconducting Nanosheets: High‐Yield Preparation and Device Fabrication (2011)

Ordentlich gestapelt: 2D-halbleitende Nanomaterialien aus einzelnen MoS2-, WS2-, TiS2-, TaS2-, ZrS2- und Graphenschichten wurden durch elektrochemische Lithiierung hergestellt (siehe Bild). Eine Ausbeute von 92 % wurde bei der Produktion einzelner MoS2-Schichten erreicht. Aus den MoS2-Schichten wurde ein Dünnschichttransistor hergestellt, der zum Nachweis von NO bis zu einer Detektionsgrenze von 190 ppt verwendet wurde. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
An iterative reconstruction algorithm for amplitude sampling (2017)

Traditional data acquisition systems rely on sampling of bandlimited signals at uniformly spaced time instants with high-precision amplitude representation. Amplitude sampling, as previously introduced by the authors, is based on uniform amplitude sampling with high precision timing information. This paper presents an iterative algorithm for signal recovery from amplitude samples and compares the results with the use of iterative recovery from the nonuniform time samples implied by the amplitude sampling process. The iterative amplitude sampling reconstruction algorithm (IASR) proposed and evaluated in this paper is based on the interpretation of amplitude sampling as uniform sampling of an associated function obtained from a reversible transformation of the bandlimited input signal. The IASR algorithm exploits uniform sampling and the frequency- and time-domain properties of the amplitude-time function. The IASR algorithm is compared with the use of iterative nonuniform sampling reconstruction as proposed by Voroni. While in numerical simulations the Voronoi algorithm converges to marginally better reconstruction than IASR, the convergence rate of IASR is significantly better.
Evaluation of Ultrasound-Assisted Thrombolysis Using Custom Liposomes in a Model of Retinal Vein Occlusion (2012)

US-assisted thrombolysis using liposomes resulted in a statistically significant reperfusion of retinal vessels in the rabbit experimental model of RVO. This approach might be promising in the treatment of RVO in humans. Further studies are needed to evaluate this approach in patients with RVO. Ultrasound assisted thrombolysis can be an innovative tool in management of retinal vein occlusion.
Basic Concepts of Broadband Communication Networks (2010)

This chapter discusses various elementary concepts of broadband communication networks. It focuses on networks in which information is transported in fixed length packets called cells. The asynchronous transfer mode (ATM) standardized worldwide, for example, assumes such a transport mechanism. To understand the motivations behind ATM, the chapter considers the limitations of the synchronous transfer mode (STM) that lead to the proposal of ATM in the first place. The chapter deals with the delays incurred by packets in an ATM network, and fixed-length versus variable-length packet switching and the issue of setting packet size. There are two types of virtual circuits in the ATM virtual-circuit hierarchy: the virtual channel (VC) and the virtual path (VP). The chapter discusses cell networking with respect to the ATM standard. Controlled Vocabulary Terms asynchronous transfer mode; broadband networks; delay estimation; delays
Correction: Perifosine and CCI 779 Co-Operate to Induce Cell Death and Decrease Proliferation in PTEN-Intact and PTEN-Deficient PDGF-Driven Murine Glioblastoma (2011)

Background: Platelet derived growth factor receptor (PDGFR) activity is deregulated in human GBM due to amplification and rearrangement of the PDGFR-alpha gene locus or overexpression of the PDGF ligand, resulting in the activation of downstream kinases such as phosphatidylinositol 3-kinase (PI3K), Akt, and mammalian target of rapamycin (mTOR). Aberrant PDGFR signaling is observed in approximately 25-30% of human GBMs, which are frequently molecularly classified as the proneural subclass. It would be valuable to understand how PDGFR driven GBMs respond to Akt and mTOR inhibition.
Development of electrospun, biomimetic tympanic membrane implants with tunable mechanical and oscillatory properties for myringoplasty (2022)

Most commonly, autologous grafts are used in tympanic membrane (TM) reconstruction. However, apart from the limited availability and the increased surgical risk, they cannot replicate the full functionality of the human TM properly. Hence, biomimetic synthetic TM implants have been developed in our project to overcome these drawbacks. These innovative TM implants are made from synthetic biopolymer polycaprolactone (PCL) and silk fibroin (SF) by electrospinning technology. Static and dynamic experiments have shown that the mechanical and oscillatory behavior of the TM implants can be tuned by adjusting the solution concentration, the SF and PCL mixing ratio and the electrospinning parameters. In addition, candidates for TM implants could have comparable acousto-mechanical properties to human TMs. Finally, these candidates were further validated in <i>in vitro</i> experiments by performing TM reconstruction in human cadaver temporal bones. The reconstructed TM with SF-PCL blend membranes fully recovered the acoustic vibration when the perforation was smaller than 50%. Furthermore, the handling, medium adhesion and transparency of the developed TM implants were similar to those of human TMs.
Resource discovery in distributed networks (1999)

Article Free Access Share on Resource discovery in distributed networks Authors: Mor Harchol-Balter MIT Laboratory for Computer Science MIT Laboratory for Computer ScienceView Profile , Tom Leighton Department of Mathematics and Laboratory for Computer Science Department of Mathematics and Laboratory for Computer ScienceView Profile , Daniel Lewin Laboratory for Computer Science Laboratory for Computer ScienceView Profile Authors Info & Claims PODC '99: Proceedings of the eighteenth annual ACM symposium on Principles of distributed computingMay 1999 Pages 229–237https://doi.org/10.1145/301308.301362Published:01 May 1999Publication History 125citation1,216DownloadsMetricsTotal Citations125Total Downloads1,216Last 12 Months92Last 6 weeks6 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Helping the most vulnerable patients. (2018)

The Methadone Treatment Protocol, now 20 years old, is a remarkable system of life-saving, health-enhancing care........
Autophagy Induced due to Moderate Endoplasmic Reticulum Stress in T Cells Enhances Immunotherapeutic Tumor Control (2020)

Abstract A number of external or internal stimuli cause endoplasmic reticulum (ER) stress conditions. In response to ER stress, stressed cells activate well-orchestrated cellular signaling processes to resolve the stress or remove itself by triggering apoptosis. In the tumor microenvironment, induction of sustained ER stress is known to dampen the antitumor activity of T cells. However, how T cells respond to suboptimal ER stimuli is unknown. Using melanoma antigen gp100 reactive T cells, we found that T cells transiently activate protein kinase R-like endoplasmic reticulum kinase (PERK) dependent signaling network to ameliorate low level of ER stress. While transient PERK activation in T cell enhances stemness, promotes mitochondrial biogenesis, increases T cells anti-tumor immunity in B16 melanoma bearing mouse, overexpression of PERK triggers T cell dysfunctionality and death. Mechanistically, we discovered that transient activation of PERK decreases overall protein translation and induces protective autophagy to prevent cell damage. Conversely, knockdown of PERK abrogates autophagy activation, hampers mitochondrial biogenesis in response to suboptimal ER stress, which in turn compromises antitumor function. Furthermore, blocking autophagy in T cells hampers T cell anti-tumor activity. Lastly, using gp100 reactive LC3-GFP expressing T cells we demonstrated that, T cells that initiate autophagy due to suboptimal ER stress show better anti-tumor potential compared to those, that fail to enter into the process. Overall, these preclinical data highlight that, both transient ER stress and autophagy pathways are important for healthy T cell function and therapeutically, can be manipulated to regulate their antitumor potential.
Construction of Azacycles by Intramolecular Amination of Organoboronates and Organobis(boronates) (2021)

Intramolecular amination of organoboronates occurs with a 1,2-metalate shift of an aminoboron "ate" complex to form azetidines, pyrrolidines, and piperidines. Bis(boronates) undergo site-selective amination to form boronate-containing azacycles. Enantiomerically enriched azacycles are formed with high stereospecificity.
Lymphoplasmacytic Cells and Mast Cells Are Targets for Imatinib Mesylate (Gleevec, Glivec) in Waldenstrom’s Macroglobulinemia. (2004)

Abstract Recently, we demonstrated that in Waldenstrom’s macroglobulinemia (WM), clonal lymphoplasmacytic cells (LPC) appear to derive growth and survival signals from excess mast cells (MC) present in the bone marrow (BM). (Tournilhac et al, JCO 2004 22:571S). We therefore have sought agents which could target both LPC and MC. One such candidate is imatinib mesylate which has shown activity in certain mast cell disorders likely on the basis of its ability to target the tyrosine kinases, CD117 (Stem Cell Factor Receptor, c-kit), and Platelet Derived Growth Factor Receptor (PDGFa-R). By flow cytometric analysis, we demonstrated CD117 expression on sorted LPC from 17/22 (76.2%) WM patients, above 20% in 13 cases, whose expressionwe confirmed by RT-PCR analysis. Moreover, we also demonstrated expression of PDGFa-R along with its ligand PDGFa in BM LPC from 16/18 (88.9%) and 7/10 (70%) WM patients.. In addition to CD117, we found by RT-PCR analysis a PDGFa expression in LAD and HMC-1 MC lines and in KU the basophilic cell lines KU as well as in sorted BM MC (FcER1+ CD117+) from 3/10 (30%) WM patients. Importantly, co-culture of sorted LPC from WM patients along with 0.5% paraformaldehyde fixed LAD cells or ex vivo expanded (EVE) BM MC induced proliferation of sorted LPC from WM patients, which was inhibited at pharmacologically achievable levels of imatinib mesylate with an IC50 of 0.5–10 μmoles/L. Moreover, imatinib mesylate inhibited the LAD, HMC-1 and KU cell lines as well as EVE cord blood MC or EVE BM MC at an IC50 of 0.01–1 μmoles/L. Lastly, imatinib mesylate also inhibited proliferation of both MC and LPC when unfixed LAD or ex vivo MC were incubated with WM LPC with an IC50 of 1–10 μmoles/L. These studies therefore demonstrate that both LPC and MC are therapeutic targets for imatinib mesylate, and provide the framework for clinical studies evaluating its use in WM.
Development of Wide-field Quantitative Multispectral Fluorescence-Reflectance Imaging Using an Ultrathin and Flexible Scanning Fiber Endoscope (2014)

Molecular imaging has drawn increasing interest in clinical diagnosis because it enables the visualization of specific markers that track disease progression at the cellular and sub-cellular level. The intersection of wide-field fluorescence endoscopic imaging and molecular biology opens up great potential for early cancer detection, quantitative assessments and more targeted/personalized treatment of diseases based on their specific molecular expression profiles. This talk will cover technologies and methodologies developed for the applications of an ultrathin and flexible multispectral Scanning Fiber Endoscope (SFE) system, including the development of universal calibration standards for quality assurance, quantitative fluorescence wide-field imaging, and image stitching to produce a panorama for inspections of small ducts and cavities in the body.
Demonstration of unpinned GaAs surface and surface inversion with gate dielectric made of Si3N4 (2007)

The authors have measured the electrical properties of metal insulator semiconductor capacitors of GaAs, with ex situ jet-vapor-deposited Si3N4 as a gate dielectric. Unpinning of GaAs surface was demonstrated by ac conductance and capacitance-voltage (C-V) measurement; GaAs surface inversion has been demonstrated by quasistatic C-V and hysteresis C-V measurements. Hydrogen plasma predeposition treatment at 200°C has been shown to reduce interface-state density. The lowest interface-state density that the authors measured was 9×1011∕cm2∕eV at 0.57eV above EV for p-type GaAs, and the smallest hysteresis window was 100mV.
151: Targeting Chemoresistant Prostate Cancer with HTI-286, a Synthetic Analogue of the Marine Sponge Product Hemiasterlin (2007)

You have accessJournal of UrologyModerated Poster 6, Sunday, May 20, 2007, 8:00 - 10:00 am1 Apr 2007151: Targeting Chemoresistant Prostate Cancer with HTI-286, a Synthetic Analogue of the Marine Sponge Product Hemiasterlin Boris A. Hadaschik, Susan Ettinger, Richard D. Sowery, Michel Roberge, and Martin E. Gleave Boris A. HadaschikBoris A. Hadaschik More articles by this author , Susan EttingerSusan Ettinger More articles by this author , Richard D. SoweryRichard D. Sowery More articles by this author , Michel RobergeMichel Roberge More articles by this author , and Martin E. GleaveMartin E. Gleave More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)30416-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "151: Targeting Chemoresistant Prostate Cancer with HTI-286, a Synthetic Analogue of the Marine Sponge Product Hemiasterlin." The Journal of Urology, 177(4S), p. 52 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 52 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Boris A. Hadaschik More articles by this author Susan Ettinger More articles by this author Richard D. Sowery More articles by this author Michel Roberge More articles by this author Martin E. Gleave More articles by this author Expand All Advertisement PDF DownloadLoading ...
Measurement-driven Evaluation of All-digital Many-antenna Full-duplex Communication. (2015)

In this paper, we present and study an all-digital method, called \softNull, to enable full-duplex in many-antenna systems. Unlike most designs that rely on analog cancelers to suppress self-interference, SoftNull relies on digital transmit beamforming to reduce self-interference. SoftNull does not attempt to perfectly null self-interference, but instead seeks to reduce self-interference sufficiently to prevent swamping the receiver's dynamic range. Residual self-interference is then cancelled digitally by the receiver. We evaluate the performance of SoftNull using measurements from a 72-element antenna array in both indoor and outdoor environments. We find that SoftNull can significantly outperform half-duplex for small cells operating in the many-antenna regime, where the number of antennas is many more than the number of users served simultaneously.
Give more data, awareness and control to individual citizens, and they will help COVID-19 containment (2021)

The rapid dynamics of COVID-19 calls for quick and effective tracking of virus transmission chains and early detection of outbreaks, especially in the "phase 2" of the pandemic, when lockdown and other restriction measures are progressively withdrawn, in order to avoid or minimize contagion resurgence. For this purpose, contact-tracing apps are being proposed for large scale adoption by many countries. A centralized approach, where data sensed by the app are all sent to a nation-wide server, raises concerns about citizens' privacy and needlessly strong digital surveillance, thus alerting us to the need to minimize personal data collection and avoiding location tracking. We advocate the conceptual advantage of a decentralized approach, where both contact and location data are collected exclusively in individual citizens' "personal data stores", to be shared separately and selectively (e.g., with a backend system, but possibly also with other citizens), voluntarily, only when the citizen has tested positive for COVID-19, and with a privacy preserving level of granularity. This approach better protects the personal sphere of citizens and affords multiple benefits: it allows for detailed information gathering for infected people in a privacy-preserving fashion; and, in turn this enables both contact tracing, and, the early detection of outbreak hotspots on more finely-granulated geographic scale. The decentralized approach is also scalable to large populations, in that only the data of positive patients need be handled at a central level. Our recommendation is two-fold. First to extend existing decentralized architectures with a light touch, in order to manage the collection of location data locally on the device, and allow the user to share spatio-temporal aggregates-if and when they want and for specific aims-with health authorities, for instance. Second, we favour a longer-term pursuit of realizing a Personal Data Store vision, giving users the opportunity to contribute to collective good in the measure they want, enhancing self-awareness, and cultivating collective efforts for rebuilding society.
Design and validation of pulse oximetry for low saturation. (2002)

As pulse oximetry migrates into new areas of patient care, it becomes increasingly important to rigorously test performance in the environment of use before claiming success. If evaluated only under tightly or ideally controlled laboratory or bench-top conditions, results may have little relationship to real-world behavior. As an example, fetal pulse oximetry sensors are subject to challenges not typically found with air-breathing patients. The "presenting part" is an attractive site for fetal oximetry, however the presence of resolvable pulses by itself does not ensure accurate readings. This study explores the effects of physiological and mechanical perturbations at low saturation expected during use on fetuses with such sensors. Numerical modeling and animal studies demonstrate that at 40% true arterial saturation (SaO2), calculated saturation values (SpO2) may err by more than 30%, even in the presence of otherwise normal pulse oximetry signals.