gebhart/patrepeval huggingface dataset:
Nanoparticles Surface Chemistry Influence on Protein Corona Composition and Inflammatory Responses (2022)

Nanoparticles are widely used for biomedical applications such as vaccine, drug delivery, diagnostics, and therapeutics. This study aims to reveal the influence of nanoparticle surface functionalization on protein corona formation from blood serum and plasma and the subsequent effects on the innate immune cellular responses. To achieve this goal, the surface chemistry of silica nanoparticles of 20 nm diameter was tailored via plasma polymerization with amine, carboxylic acid, oxazolines, and alkane functionalities. The results of this study show significant surface chemistry-induced differences in protein corona composition, which reflect in the subsequent inflammatory consequences. Nanoparticles rich with carboxylic acid surface functionalities increased the production of pro-inflammatory cytokines in response to higher level of complement proteins and decreased the number of lipoproteins found in their protein coronas. On another hand, amine rich coatings led to increased expressions of anti-inflammatory markers such as arginase. The findings demonstrate the potential to direct physiological responses to nanomaterials via tailoring their surface chemical composition.
ELIoT: New Features in LiFi for Next-Generation IoT (2021)

The Internet of Things currently is predominantly narrowband and cannot always guarantee high reliability and low latency. Future IoT applications such as flexible manufacturing, augmented reality and self-driving vehicles need sophisticated real-time processing units in the cloud to which mobile IoT devices are connected. These high-capacity links meet the requirements of the upcoming 6G systems and cannot be facilitated by the current mobile communication infrastructure. Light communication, which is also denoted as LiFi, offers huge amounts of spectrum, extra security and interference-free transmission. We present the current state-of-the-art of LiFi systems and introduce new features needed for future IoT applications. We propose a distributed Multiple-Input Multiple-Output topology with a fronthaul using plastic optical fiber. Such a system offers seamless mobility between the light access points and also to 5G, besides low latency and integrated positioning. Future LiFi development, implementation and efforts towards standardization are addressed in the EU ELIoT project which is presented here.
Fertility preservation for pediatric male cancer patients: illustrating contemporary and future options; a case report (2021)

The main aim of current pediatric male fertility preservation programs is storing spermatogonia stem cell (SSC) prior to starting cancer treatment. From July 1st, 2014 to May 1st, 2020; 170 patients have been recruited in Wake Forest Testicular Tissue Banking Program. The existence of multiple testis biopsies in different time points and detailed histological analyses of a unique cancer patient, provided an educational opportunity to investigate testis condition in different phases of cancer management. A pediatric male cancer patient with B-cell acute lymphoblastic leukemia (ALL) had multiple testicular leukemia recurrences and went through several testicular biopsies, to identify leukemic infiltration as well as considering fertility preservation. Infiltration of leukemia cells into both testes was identified. Neither elongated spermatid nor sperm were detected, but germ cells including SSC, spermatocyte and round spermatid could be identified in the stored tissue even after initial cancer treatment. Different germ cells were identified by hematoxylin and eosin (H&E) staining and specific immunohistochemical (IHC) markers including PGP9.5/UCHL1 or MAGE-A4 (spermatogonia), SYCP3 (spermatocyte) and PRM1 (round spermatid). This emphasizes the importance of offering testicular biopsy to pediatric cancer patients at risk of infertility regardless to the stage of cancer treatment, although earlier biopsy is preferred. Promising research on <i>in vitro</i> spermatogenesis and auto-transplantation support the practice of SSC preservation. In addition, finding and storing round spermatids isolated from testicular biopsy provides a currently available option of round spermatid injection (ROSI). Given the complexity of managing cancer while considering fertility preservation, a multidisciplinary collaboration is important to achieve optimal overall outcomes.
A Study on The Planning of The Administration Facilities in University Campus (1996)

The university administration building is one of the most important structure in campuses in terms of its functional roll providing all the institutional services and its symbolic value that represents the school. But we can still find many universities carrying on without administration buildings, And even though in the cases that have their own administration buildings, the architectural qualities of the buildings often can not meet the basic requirements for a worthwhile administration building. Because of its complex and complicated nature, planning and designing university administrative facilities are not an easy task to be successful. This study aims to provide the basic directions in designing university administration building through the survey of the facilities in the existing campuses.
Validation of SMURF Estimation of Shear Modulus in Hydrogels (2009)

A validation study of the Spatially Modulated Ultrasound Radiation Force (SMURF) method for shear modulus estimation is presented. SMURF estimates of uniform gelatin and Zerdine phantoms covering a modulus range of 2 to 18 kPa are compared with results obtained by unconfined mechanical compression and sonoelastography. The results show agreement within the measurement uncertainties over the range indicated for all three methods. Repeatability and variation on the order of 5% of the phantom modulus are found for observations made at a single point within the phantom. Averaging of modulus estimates from several adjacent scan lines further decreases the variation. By using multiple radiation force peaks to induce a shear wave of known wavelength and measure the frequency of the wave, SMURF obtains modulus estimates from tracking data acquired along a single A-line. This is significant, as speckle can bias the measured phase of the shear wave. SMURF is shown to be insensitive to a constant phase error in the shear wave measurement. This results in greatly reduced correlated noise in the modulus estimates, in contrast with methods which track at multiple locations and do not cancel phase errors.
Improving Hematopoietic Stem Cell Based Gene Therapy By Targeting CD133+ Cells (2013)

Abstract Introduction Generally, CD34+ cells are used for genetic modification in gene therapy trials. CD34+ cells consist of a heterogeneous cell population with mostly limited long-term repopulating capabilities, resulting in low long-term engraftment levels in particular in those diseases in which gene modified cells lack a proliferative advantage over non-modified cells. Therefore, modifications in gene transfer vectors and gene transfer strategies are required to improve long-term clinical benefit in gene therapy patients. One particular attractive approach to solve this problem is the improvement of HSC based gene transfer by specifically targeting cells with long-term engraftment capabilities. Material and Methods We constructed lentiviral gene transfer vectors (LV) specifically targeting CD133+ cells, a cell population with recognized long-term repopulating capabilities. Targeting is achieved by pseudotyping with engineered measles virus (MV) envelope proteins. The MV glycoprotein hemagglutinin, responsible for receptor recognition, is blinded for its native receptors and displays a single-chain antibody specific for CD133 (CD133-LV). These vectors were compared to VSV-pseudotyped lentiviral vectors in in vitro and in vivocompetitive repopulation assays using mobilized peripheral blood CD34+ cells. Results Superior transduction of isolated human hematopoietic stem cell populations (CD34+CD38- or CD34+CD133+ cells) compared to progenitor cell populations (CD34+CD38+ or CD34+CD133-) could be shown using the newly developed CD133-LV. Transduction of total CD34+ cells with CD133-LV vectors resulted in stable gene expression and gene marked cells expanded in vitro, while the number of VSV-G-LV transduced CD34+ cells declined over time. Competitive repopulation experiments in NSG mice showed a significantly improved engraftment of CD133-LV transduced HSCs. At ∼12 weeks post-transplantation gene marked hematopoiesis was dominated by the progeny of CD133-LV transduced cells in 42 out of 52 transplanted animals in the bone marrow and 39 out of 45 transplanted animals in the spleen, respectively. Consistent with this data we could show that stem cell content in the CD133-LV transduced population is about five times higher compared to the VSV-transduced population using a limiting dilution competitive repopulation assay (LDA-CRU). Experiments showing proof of principle for the application of this technology for the correction of Chronic Granulomatous Disease (XCGD) using patient derived CD34+ cells are currently ongoing. Discussion In conclusions this new strategy may be promising to achieve improved long-term engraftment in patients treated by gene therapy. Disclosures: No relevant conflicts of interest to declare.
The Underlying Mechanisms for Olanzapine-induced Hypertriglyceridemia (2012)

Olanzapine is an efficacious antipsychotic drug often used in the treatment for schizophrenia or bipolar disorder, however, sometimes induces metabolic disorders. We will introduce a patient with bipolar disorder, who has been treated by olanzapine and showed severe hypertriglyceridemia. As a result of measurements of parameters associated with lipid metabolism, very-low density lipoprotein was most important lipoprotein for olanzapin-induced hypertriglyceridemia. The cessation of olanzapine significantly decreased high-sensitivity C-reactive protein and increased adiponectin, proposing that inflammation and reduced adiponectin level may be associated with olanzapin-induced hypertriglyceridemia.
Quirky negative concord (2021)

This paper explores the interaction between connective negation (‘neither ... nor’) and negative concord, an issue that has not received much attention. It looks at different ‘negative concord’ languages, viz. Croatian, Spanish, and French. The approach is synchronic; the data come from existing descriptions and from native speaker judgments. The paper describes the many idiosyncrasies but also lays bare some of the similarities.
Field Investigation of Salt Transport Processes Using Resistivity/IP Imaging (1999)

PreviousNext No AccessSymposium on the Application of Geophysics to Engineering and Environmental Problems 1999Field Investigation of Salt Transport Processes Using Resistivity/IP ImagingAuthors: Lee SlaterStewart K. SandbergLee SlaterDept. of Geosciences, University of S. Maine, 37 College Avenue, Gorham, ME04038 and Stewart K. SandbergDept. of Geosciences, University of S. Maine, 37 College Avenue, Gorham, ME04038https://doi.org/10.4133/1.2922662 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Abstract Introductory paragraph for this paper is available only in the PDF and GZipped PS filesPermalink: https://doi.org/10.4133/1.2922662FiguresReferencesRelatedDetails Symposium on the Application of Geophysics to Engineering and Environmental Problems 1999ISSN (online):1554-8015Copyright: 1999 Pages: 997 publication data© 1999 Copyright © 1999 The Environmental and Engineering Geophysical SocietyPublisher:Environmental & Engineering Geophysical Society HistoryPublished: 30 Sep 2008 CITATION INFORMATION Lee Slater and Stewart K. Sandberg, (1999), "Field Investigation of Salt Transport Processes Using Resistivity/IP Imaging," Symposium on the Application of Geophysics to Engineering and Environmental Problems Proceedings : 647-656. https://doi.org/10.4133/1.2922662 Plain-Language Summary PDF DownloadLoading ...
Preliminary investigation of AdaptiSPECT-C designs with square or square and hexagonal detectors employing direct and oblique apertures (2019)

We report our investigation of system designs and 3D reconstruction for a dedicated brain-imaging SPECT system using multiple square or square and hexagonal detector modules. The system employs shuttering to vary which of multiple pinhole apertures are enabled to pass photons through to irradiate the detectors. Both multiplexed and nonmultiplexed irradiation by the pinholes are investigated. Sampling is assessed by simulated imaging of a uniform activity concentration in a spherical tub filling the VOI and a tailored Defrise phantom consisting of a series of activity containing slabs aligned axially. Potential image quality for clinical imaging is assessed through simulated imaging of an XCAT brain phantom with an activity distribution simulating perfusion imaging.
GIS METHODOLOGICAL APPROACHES FOR EXPOSURE ASSESSMENT OF GROUNDWATER ARSENIC IN NOVA SCOTIA (2004)

ISEE-517 Introduction: The purpose of this investigation was to explore the development of a spatial exposure assessment strategy in order to support epidemiological research on groundwater arsenic exposure and health for Nova Scotia. Methods: Total arsenic concentration data geocoded by the given address and postal code in the data file was obtained from provincial sources. Previously geocoded data were checked for accuracy and omissions; corrections were completed using the Nova Scotia Gazetteer, ArcView 3.2 (ESRI) and the Nova Scotia Atlas. Individual arsenic records were initially depicted as points; each point was coloured-coded by incremental arsenic concentration categories (less than 2 g/l, 2 to 10 g/L, 10 to 25 ug/l and above 25 g/L). Probability kriging methods were next applied to spatially interpolate unsampled areas. The final method explored was a 10 km x 10 km grid-based approach, modeling after the US Geological Survey methods. This was created and linked to individual arsenic records. Grid cells were then categorized according to the above classification scheme, with the additional category of insufficient data (n<=4). Different algorithms were then applied to the development of the exposure scheme: at least one value at the designated highest level observed in the cell, the average concentration, and the level to which the highest 25% of the grid records corresponded. The distribution of the groundwater samples were also mapped. Software used for the mapping process included Microsoft Excel, ArcView 3.2, ArcGIS 8.2 (ESRI), and MapInfo Professional 6.0. Results: Both the point-representation and kriging maps were deemed inappropriate due to the unevenness of the data distribution, concerns for spatial precision, problems of overlapping points and issues of confidentiality. The grid mapping approach was most appropriate, but differences in the algorithms led to marked differences in exposure presentation. Hot spots were highlighted for the algorithm where even a single sample in a grid cell attained a maximum categorical level. The algorithm requiring 25% of the samples to attain a given level provided a more conservative view and may underestimate exposure risk. The average arsenic level map showed intermediate levels of arsenic exposure, compared to the other two. Discussion: The results of this study demonstrate how the choices of spatial algorithms and representation can dramatically impact exposure designation and, ultimately, perceived risk. Careful attention must be given to these considerations if one is planning to use spatial data to represent community exposures to environmental hazards.
Identifying critically important vascular access outcomes for trials in haemodialysis: an international survey with patients, caregivers and health professionals (2019)

Patients and HPs believe that all cardiovascular outcomes are of critical importance but consistently identify sudden cardiac death, myocardial infarction, stroke and heart failure as the most important outcomes to be measured in all HD trials.
Biomass‐Derived Chemicals: Synthesis of Biodegradable Surfactant Ether Molecules from Hydroxymethylfurfural (2013)

A new class of biodegradable anionic surfactants with structures based on 5-alkoxymethylfuroate was prepared starting from 5-hydroxymethylfurfural (HMF), through a one-pot-two-steps process which involves the selective etherification of HMF with fatty alcohols using heterogeneous solid acid, followed by a highly selective oxidation of the formyl group with a gold catalyst. The etherification step was optimized using aluminosilicates as acid catalysts with different pore topologies (H-Beta, HY, Mordenite, ZSM-5, ITQ-2, and MCM-41), different active sites (Bronsted or Lewis) and different adsorption properties. It was shown that highly hydrophobic defect-free H-Beta zeolites with Si/Al ratios higher than 25 are excellent acid catalysts to perform the selective etherification of HMF with fatty alcohols, avoiding the competitive self-etherification of HMF. Moreover, the 5-alkoxymethylfurfural derivatives obtained can be selectively oxidized to the corresponding furoic salts in excellent yield using Au/CeO2 as catalyst and air as oxidant, at moderated temperatures. Both H-Beta zeolite and Au/CeO2 could be reused several times without loss of activity.
Augmented Responses to Ozone in Obese Mice Require IL-17A and Gastrin-Releasing Peptide (2017)

Abstract Ozone and obesity both increase IL-17A in the lungs. In mice, obesity augments the airway hyperresponsiveness and neutrophil recruitment induced by acute ozone exposure. Therefore, we examined the role of IL-17A in obesity-related increases in the response to ozone observed in obese mice. Lean wild-type and obese db/db mice were pretreated with IL-17A–blocking or isotype antibodies, exposed to air or ozone (2 ppm for 3 h), and evaluated 24 hours later. Microarray analysis of lung tissue gene expression was used to examine the mechanistic basis for effects of anti–IL-17A. Compared with lean mice, ozone-exposed obese mice had greater concentrations of BAL IL-17A and greater numbers of pulmonary IL-17A+ cells. Ozone-induced increases in BAL IL-23 and CCL20, cytokines important for IL-17A+ cell recruitment and activation, were also greater in obese mice. Anti–IL-17A treatment reduced ozone-induced airway hyperresponsiveness toward levels observed in lean mice. Anti–IL-17A treatment also reduced BAL neutrophils in both lean and obese mice, possibly because of reductions in CXCL1. Microarray analysis identified gastrin-releasing peptide (GRP) receptor (Grpr) among those genes that were both elevated in the lungs of obese mice after ozone exposure and reduced after anti–IL-17A treatment. Furthermore, ozone exposure increased BAL GRP to a greater extent in obese than in lean mice, and GRP-neutralizing antibody treatment reduced obesity-related increases in ozone-induced airway hyperresponsiveness and neutrophil recruitment. Our data indicate that IL-17A contributes to augmented responses to ozone in db/db mice. Furthermore, IL-17A appears to act at least in part by inducing expression of Grpr.
Luminescent characteristics of a novel porous silicon structure formed in a nonaqueous electrolyte (1994)

Novel porous silicon layers which photoluminesce and electroluminesce in an aqueous solution have been formed by oxidation of (100) silicon in anhydrous acetonitrile-HF solutions. The novel porous structures consisted of large, noninterconnected pores, 1–2 μm diam, which grew normal to the surface. The pores were spaced 2–3 μm apart, and the length, which could be over 150 μm, was dependent on etch time and current density. Microporous structures (i.e., &amp;lt;100 nm), often associated with luminescence from porous silicon, were not detected by TEM, SEM, or infrared examination. The porous surface was hydride terminated, which was critical to the luminescence process. Since water and oxygen were not present during the formation of the porous structure and the pores were relatively large, neither silicon-oxygen species (e.g., siloxenes) nor quantum size structures, appeared necessary for the generation visible luminescence from porous silicon.
APPLICATIONS OF SIMULATION IN DESIGN AND ANALYSIS OF ROADSIDE SAFETY FEATURES (1995)

Roadside safety features present many challenging design and analysis problems. Although full-scale crash testing continues to be the only method for certifying the performance of roadside safety features, engineers have come to rely on computer simulation programs for analysis of the performance of these systems. Computer simulation codes are generally lumped into two categories, vehicle handling programs and impact models. Vehicle handling codes are used to evaluate safety problems associated with roadway and roadside geometrics, such as slopes, ditches, and curbs. Impact models are used to evaluate the safety performance of numerous safety hardware systems such as longitudinal barriers, crash cushions, barrier terminals, and breakaway structures. Among the computer simulation models discussed in this workshop paper are the Highway Vehicle Object Simulation Model (HVOSM), Barrier VII, and FEM vehicle models such as DYNA3D.
Terahertz aptasensor for dopamine neurochemical detection (2023)

Abstract Measuring neurotransmitter levels in the body can identify imbalances and diagnose neurological and psychiatric disorders. Several advanced imaging technologies and electrochemical and optical sensors have been developed for a highly sensitive and selective detection of neurotransmitters. In this study, a terahertz chemical microscope (TCM) for measurement of dopamine levels is proposed. The TCM uses terahertz waves to obtain a label-free chemical reaction on a sensing plate. A DNA aptamer is investigated as a recognition element for detection of dopamine. The measurement mechanism and construction of the terahertz aptasensor are described, providing a potential alternative for neurotransmitter detection.
Fibrin gel structure obtained with a FVIIa analogue with enhanced FX-activating potential in haemophilia (2009)

Fibrin gel structure obtained with a FVIIa analogue with enhanced FX-activating potential in haemophilia -
Joint Microstrip Selection and Beamforming Design for MmWave Systems with Dynamic Metasurface Antennas (2022)

Dynamic metasurface antennas (DMAs) provide a new paradigm to realize large-scale antenna arrays for future wireless systems. In this paper, we study the downlink millimeter wave (mmWave) DMA systems with limited number of radio frequency (RF) chains. By using a specific DMA structure, an equivalent mmWave channel model is first explicitly characterized. Based on that, we propose an effective joint microstrip selection and beamforming scheme to accommodate for the limited number of RF chains. A low-complexity digital beamforming solution with channel gain-based microstrip selection is developed, while the analog beamformer is obtained via a coordinate ascent method. The proposed scheme is numerically shown to approach the performance of DMAs without RF chain reduction, verifying the effectiveness of the proposed schemes.