gebhart/patrepeval huggingface dataset:
Gene Expression Profile Changes After Short-activating RNA-mediated Induction of Endogenous Pluripotency Factors in Human Mesenchymal Stem Cells (2012)

It is now recognized that small noncoding RNA sequences have the ability to mediate transcriptional activation of specific target genes in human cells. Using bioinformatics analysis and functional screening, we screened short-activating RNA (saRNA) oligonucleotides designed to target the promoter regions of the pluripotency reprogramming factors, Kruppel-like factor 4 (KLF4) and c-MYC. We identified KLF4 and c-MYC promoter-targeted saRNA sequences that consistently induced increases in their respective levels of nascent mRNA and protein expression in a time- and dose-dependent manner, as compared with scrambled sequence control oligonucleotides. The functional consequences of saRNA-induced activation of each targeted reprogramming factor were then characterized by comprehensively profiling changes in gene expression by microarray analysis, which revealed significant increases in mRNA levels of their respective downstream pathway genes. Notably, the microarray profile after saRNA-mediated induction of endogenous KLF4 and c-MYC showed similar gene expression patterns for stem cell- and cell cycle-related genes as compared with lentiviral vector-mediated overexpression of exogenous KLF4 and c-MYC transgenes, while divergent gene expression patterns common to viral vector-mediated transgene delivery were also noted. The use of promoter-targeted saRNAs for the activation of pluripotency reprogramming factors could have broad implications for stem cell research.
Predictive control of a single-stage boost DC-AC photovoltaic microinverter (2016)

Commercial photovoltaic microinverter topologies are normally composed of two stages: a step-up dc-dc stage and a step-down dc-ac stage. Nevertheless, to achieve high-ratio conversion, a high frequency transformer is used in the dc-dc stage, resulting in a bulky configuration with a high cost of implementation. To minimize these issues, a single stage boost inverter is proposed, composed by two bidirectional boost dc-dc converter. The control of this topology is complex due to its high non-linearity behaviour. Therefore, this paper presents a control methodology based on Finite Control Set Model Predictive Control (FCS-MP) algorithm with predictions of the system variables through the inverter model and an optimization process. Each boost dc-dc converter of the inverter is regulated to achieve an output signal composed of the sinusoidal wave with a dc bias. The main features of the boost inverter and predictive control are analysed. Simulations are shown in order to validate the proposed control and the converter for grid-connected PV applications.
Direct Binary Search Computer-Generated Holograms: An Accelerated Design Technique And Measurement Of Wavefront Quality (1989)

The iterative direct binary search (DBS) algorithm for the synthesis of binary computer-generated holograms (CGH&apos;s) has been shown to yield lower reconstruction error and higher diffraction efficiency than conventional methods; but it is computationally intensive. To ameliorate this disadvantage, an acceleration technique is described which makes feasible the design of CGH&apos;s with moderate space-bandwidth product. The ability to control both the magnitude and phase of the reconstructed wavefront is an important advantage of DBS over the use of phase shaping to improve diffraction efficiency with conventional methods for CGH synthesis. To verify this capability, a procedure has been developed for measuring the phase of the reconstructed wavefront.
Superficial Siderosis of the Central Nervous System (2011)

SSCN is a destructive disorder affecting the auditory-vestibular system. Although not a common diagnosis, SSCN may be more prevalent than clinicians realize. Site of lesion may be anywhere within the auditory-vestibular system from the inner ear to the cortex, although the cochleovestibular nerve and cerebellum are particularly vulnerable. The progressive retrocochlear nature of the disorder makes differential diagnosis difficult and development of effective treatment options challenging. It is essential that audiologists and otologists recognize this uncommon cause of sensorineural hearing loss and balance disorder and the implications for evaluation, treatment, and counseling.
Cutting Edge: Cbl-b: One of the Key Molecules Tuning CD28- and CTLA-4-Mediated T Cell Costimulation (2004)

Cbl-b negatively regulates CD28-dependent T cell activation. In this report, we tested the hypothesis that CD28 and CTLA-4 have opposite roles in tuning T cell activation threshold by controlling the levels of Cbl-b protein expression. We demonstrate that CD28 costimulation potentiates TCR-induced Cbl-b degradation, whereas CTLA-4-B7 interaction is required for Cbl-b re-expression. In support of this finding, Cbl-b expression in CTLA-4 knockout (KO) T cells is significantly reduced, and treating CTLA-4KO mice with human CTLA-4Ig to block CD28-B7 interaction restores Cbl-b expression on T cells. Furthermore, CD28 and CTLA-4 costimulatory effects are compromised in Cbl-bKO T cells. These observations indicate that CD28 and CTLA-4 tightly regulate Cbl-b expression which is critical for establishing the threshold for T cell activation.
Compensation of packet loss for a network-based rehabilitation system (2012)

In this paper, a network-based rehabilitation system is proposed to increase mobility of a rehabilitation system and to enable tele-rehabilitation. Control algorithms and rehabilitation strategies distributed at the central location (physical therapist) and the local site (patient) communicate over wireless network to realize a network-based rehabilitation system. To deal with possible packet losses over wireless network, a modified linear quadratic Gaussian (LQG) controller and a disturbance observer (DOB) are applied. The performance of the proposed system and control algorithms is verified by simulation and experiment with an actual knee rehabilitation system. The simulation and experiment results show that the network-based rehabilitation system with the proposed control schemes can generate the desired assistive torque accurately in presence of packet losses.
High incidence of type 2 diabetes and increasing conversion rates from impaired fasting glucose and impaired glucose tolerance to diabetes in Mauritius (2004)

In this study, we report changes in incidence rates of glucose intolerance over a 11-year period. In particular, differences between men and women were observed. The increased incidence of IGT in women compared with men, and increased incidence of IFG in men compared with women was consistent with, and explains the sex biases seen in the prevalences of these states.
The Aryl Hydrocarbon Receptor as a regulator of CNS autoimmunity (2019)

Abstract Therapeutic approaches aimed at controlling the balance between effector T cells and regulatory T cells in an antigen-specific manner are of high clinical significance in the field of autoimmunity. The aryl hydrocarbon receptor (AhR) has been identified as a key regulator of the adaptive immune system and thus represents a strong targetable candidate for the induction of immune tolerance. Here, we report the generation of a novel liposomal platform to co-administer a tolerogenic AhR ligand, ITE, and an autoimmune disease-specific T cell antigen. Liposomes containing ITE and a T-cell epitope from myelin oligodendrocyte glycoprotein (MOG)35–55 are taken up by dendritic cells and induce a tolerogenic transcriptional program which promotes the differentiation and expansion of long-lasting antigen-specific regulatory T cells. Treatment with these liposomes almost completely prevented the development of experimental autoimmune encephalomyelitis (EAE), an experimental model of relapsing-remitting multiple sclerosis (MS), and reversed symptoms in mice with ongoing EAE. This disease suppression was associated with the expansion of antigen-specific FoxP3+ regulatory T cells (Treg cells) and type 1 regulatory T cells (Tr1 cells) as well as the suppression of CNS-infiltrating effector T cells. Furthermore, treatment with liposomes containing ITE and MOG reversed symptoms of disease in chronic progressive EAE in nonobese diabetic mice, an experimental model resembling several aspects of secondary progressive MS. Taken together, these results suggest that our liposomes represent a novel therapeutic platform to induce antigen-specific tolerance for the treatment of autoimmune diseases.
Extremely Efficient Liquid Exfoliation and Dispersion of Layered Materials by Unusual Acoustic Cavitation (2014)

Layered materials must be exfoliated and dispersed in solvents for diverse applications. Usually, highly energetic probe sonication may be considered to be an unfavourable method for the less defective exfoliation and dispersion of layered materials. Here we show that judicious use of ultrasonic cavitation can produce exfoliated transition metal dichalcogenide nanosheets extraordinarily dispersed in non-toxic solvent by minimising the sonolysis of solvent molecules. Our method can also lead to produce less defective, large graphene oxide nanosheets from graphite oxide in a short time (within 10 min), which show high electrical conductivity (>20,000 S m−1) of the printed film. This was achieved by adjusting the ultrasonic probe depth to the liquid surface to generate less energetic cavitation (delivered power ~6 W), while maintaining sufficient acoustic shearing (0.73 m s−1) and generating additional microbubbling by aeration at the liquid surface.
A study on characteristic basis function method using combined IP-CBF (2017)

We proposed an improved technique of the analysis accuracy for the characteristic basis function method (CBFM) using the multilevel approach. In this technique, improved primary CBFs (IP-CBFs) are used for taking into account multiple scattering between each block. The radar cross section (RCS) of a perfect electric conductor cube was analyzed by using the proposed technique. It was found that analysis accuracy is improved compared by the results of the conventional method.
Optimization of element positions for direction finding with sparse arrays (2002)

Sparse arrays are attractive for direction-of-arrival (DOA) estimation since they can provide accurate estimates at a low cost. A problem of great interest in this matter is to determine the element positions that yield the best DOA estimation performance. A major difficulty with this problem is to define a suitable performance measure to optimize. A novel criterion is proposed for optimizing element positions. The ambiguity threshold of the Weiss-Weinstein bound (1985) is used to optimize the element positions of a sparse linear array. The array obtained from the optimization is compared with some other sparse array structures that have been proposed in the literature.
Lasing Action in Air Induced by Ultrafast Laser Filamentation (2004)

Backscattered fluorescence from nitrogen molecules from filaments induced by intense, ultrafast Ti:sapphire laser pulses increases exponentially with an increase in the length of the filament. This shows that the fluorescence undergoes amplified spontaneous emission along the filament direction, a finding that could have applications in lightning discharge control and remote sensing.
Deep-learning-based hepatic fat assessment (DeHFt) on non-contrast chest CT and its association with disease severity in COVID-19 infections: A multi-site retrospective study (2022)

For a full list of funding bodies, please see the Acknowledgements.
The Allosteric Regulation of Phenylalanine Hydroxylase Provides a Foundation for New PKU Therapies (2013)

The structural basis for allostery in phenylalanine hydroxylase (PAH), whose dysfunction causes phenylketonuria (PKU), is poorly understood. A dissociative model for PAH allostery is proposed to consist of an equilibrium between architecturally different tetramers whose interconversion requires a ~90Â° rotation between PAH catalytic and regulatory domains, the latter of which contains an ACT domain. This unprecedented model is supported by in vitro data on purified full length mammalian PAH. The conformational change renders the tetramers chromatographically separable using ion exchange methods. A novel aspect of the activated tetramer model is an allosteric Phe binding site at an inter‐subunit interface of ACT domains; this provides a structural rationale for Phe‐induced tetramer stabilization. Ligand‐stabilized ACT domain dimerization follows the multimerization and ligand binding behavior of ACT domains in the PDB. Spectroscopic, chromatographic, and electrophoretic methods demonstrate a PAH equilibrium consisting of architecturally distinct tetramers as well as dimers. We postulate that PKU‐associated mutations may shift the PAH quaternary structure equilibrium in favor of the low activity assemblies. Pharmacological chaperones that bind to and stabilize the ACT:ACT interface can potentially provide PKU patients with a novel small molecule therapeutic. Supported by NIH P30CA006927.
Differentially Flat Designs of Underactuated Mobile Manipulators (2010)

This paper presents a methodology for design of mobile vehicles, mounted with underactuated manipulators operating in a horizontal plane, such that the combined system is differentially flat. A challenging question of how to perform point-to-point motions in the state space of such a highly nonlinear system, in spite of the absence of some actuators in the arm, is answered in this paper. We show that, by appropriate inertia distribution of the links and addition of torsion springs at the joints, a range of underactuated designs is possible, where the underactuated mobile manipulator system is differentially flat. The differential flatness property allows one to efficiently solve the problem of trajectory planning and feedback controller design for point-to-point motions in the state space. The proposed method is illustrated by the example of a mobile vehicle with an underactuated three-link manipulator.
Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors. (1994)

We have cloned Rev-erb beta, a novel isoform of the Rev-erb alpha orphan nuclear receptor. The DNA binding domains of Rev-erb alpha and beta are highly related to each other and to the retinoic acid related orphan receptor (ROR)/RZR subfamily of nuclear receptors. Indeed, we find that all three receptors bind as monomers to the sequence AATGT-AGGTCA. Whereas ROR alpha 1 constitutively activates transcription through this sequence, both isoforms of Rev-erb are inactive. When coexpressed, both Rev-erb isoforms suppress the transcriptional activity of ROR alpha 1. Our data define Rev-erb and ROR/RZR as a family of related receptors with opposing activities on overlapping regulatory networks.
Apollony photonic sponge based photoelectrochemical solar cells (2006)

We have developed a quasi-fractal colloidal crystal to localize efficiently photons in a very broad optical spectral range; it has been applied to prepare dye sensitized photoelectrochemical solar (PES) cells able to harvest very efficiently photons from the ultraviolet (UV) and the visible (VIS) regions of the solar spectrum.
The random phase transducer in ultrasonic nondestructive testing of coarse grain stainless steel: An original tool to characterize multiple scattering effect (2003)

Ultrasonic nondestructive testing of cast stainless steel is difficult due to a high level speckle noise generated by the coarse grain structure. Multiple scattering of acoustic waves, explains deteriorations of focusing beyond about 2 MHz. Random phase transducers that are shown to be useful in controlling such materials are presented. Their ability to reduce speckle noise is linked to the quantity of uncorrelated information measured by the transducer. Experimental results are compared with those obtained with a standard spatial compounding technique. These results show the efficiency of the random phase transducer in order to characterize the multiple scattering effect.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
3-hydroxy-3-methylglutaric aciduria presenting with Reye like syndrome: report of one case. (2000)

We report the case of a patient with 3-hydroxy-3-methylglutaric aciduria who presented with a repeat attack of Reye like syndrome clinically. Vomiting and somnolence, generalized tonic and clonic convulsions with hepatomegaly, hyperammonemia, liver function impairment, and mild metabolic acidosis were the presenting signs. 3-hydroxyisovaleric, 3-methylglutaric, 3-methylglutaconic and 3-hydroxy-3-methylglutaric acids were detected in the urine by gas chromatography-mass spectrometry. 3-methylglutarylcarnitine was also identified in the urine by fast atom bombardment and tandem mass spectrometry. Therefore, the possibility of metabolic disease should be considered in neonates and infants with repeat attacks of Reye like syndrome and a history of similarly affected siblings.
Multiple bonds between transition metals and main-group elements. 74. Five-membered rhenacycles through condensation reactions of methyl(trioxo)rhenium(VII) with bidentate ligands. X-ray crystal structures of 8-oxyquinolinato and catecholato complexes (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple bonds between transition metals and main-group elements. 74. Five-membered rhenacycles through condensation reactions of methyl(trioxo)rhenium(VII) with bidentate ligands. X-ray crystal structures of 8-oxyquinolinato and catecholato complexesJanos Takacs, Paul Kiprof, Juergen Riede, and Wolfgang A. HerrmannCite this: Organometallics 1990, 9, 3, 782–787Publication Date (Print):March 1, 1990Publication History Published online1 May 2002Published inissue 1 March 1990https://pubs.acs.org/doi/10.1021/om00117a038https://doi.org/10.1021/om00117a038research-articleACS PublicationsRequest reuse permissionsArticle Views185Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Polar-Coded Modulation for Joint Channel Coding and Probabilistic Shaping (2019)

We propose joint channel coding and constellation shaping based on polar-coded modulation. Proposed shaping method offers more than 0.6 dB gain without the need of external distribution matcher and the increase of decoding complexity.
Growth characteristics, material properties, and optical properties of zinc oxysulfide films deposited by atomic layer deposition (2011)

Zinc oxysulfide—Zn(O,S)—is a wide bandgap semiconductor with tunable electronic and optical properties, making it of potential interest as a buffer layer for thin film photovoltaics. Atomic layer deposition (ALD) of ZnS, ZnO, and Zn(O,S) films from dimethylzinc, H2O, and H2S was performed, and the deposited films were characterized by means of x-ray diffraction, x-ray photoelectron spectroscopy, and spectroscopic ellipsometry. With focus on the investigation of Zn(O,S) film growth characteristics and material properties, the ZnO/(ZnO + ZnS) ALD cycle ratios were systematically varied from 0 (ZnS ALD) to 1 (ZnO ALD). Notably, a strong effect ofthematerial properties on the optical characteristics is confirmed for the ternary films. The Zn(O,S) ALD growth and crystal structure resemble those of ZnS up to a 0.6 cycle ratio, at whichpoint XPS indicates 10% oxygen is incorporated into the film. For higher cycle ratios thefilm structure becomes amorphous, which is confirmed with XRD patterns and also reflected inthe optical constants as determined by spectroscopic ellipsometry; in particular, the optical bandgap transforms from direct type for the (cubic) ZnS like phase to a more narrow bandgap withamorphous characteristics, causing bandgap bowing. A direct bandgap is recovered atyethigherZnO/(ZnO + ZnS) cycle ratios, whereproperties converge toward ZnO ALD in termsof film growth rate, crystallinity, and composition.
Cross Layer Analysis of Queuing with AMC Through GMSK Modulation Over Wireless Links (2008)

Wireless communication plays an important role in today's environment. To have an effective communication there must be interaction between different layers of OSI model. In this paper we propose a cross layer design for combining queuing and adaptive modulation and coding (AMC) which includes a new modulation technique Gaussian minimum shift keying (GMSK). Gaussian minimum shift keying (GMSK) modulation is widely used in cellular and PCS applications. One of the important considerations in the use of modulation is the average power spectral density and especially the spectral density characteristics on the tails. Already proposed AMC module for cross-layer design has included the modulations like BPSK, QPSK, QAM etc. In order to maximize spectral efficiency under prescribed delay and performance constraints, GMSK is proposed in this paper.
Modeling the properties of PECVD silicon dioxide films using optimized back-propagation neural networks (1994)

Silicon dioxide films deposited by plasma-enhanced chemical vapor deposition (PECVD) are useful as interlayer dielectrics for metal-insulator structures such as MOS integrated circuits and multichip modules. The PECVD of SiO/sub 2/ in a SiH/sub 4//N/sub 2/O gas mixture yields films with excellent physical properties. However, due to the complex nature of particle dynamics within the plasma, it is difficult to determine the exact nature of the relationship between film properties and controllable deposition conditions. Other modeling techniques, such as first principles or statistical response surface methods, are limited in either efficiency or accuracy. In this study, PECVD modeling using neural networks has been introduced. The deposition of SiO/sub 2/ was characterized via a 2/sup 5-1/ fractional factorial experiment, and data from this experiment was used to train feed-forward neural networks using the error back-propagation algorithm. The optimal neural network structure and learning parameters were determined by means of a second fractional factorial experiment. The optimized networks minimized both learning and prediction error. From these neural process models, the effect of deposition conditions on film properties has been studied, and sensitivity analysis has been performed to determine the impact of individual parameter fluctuations. The deposition experiments were carried out in a Plasma Therm 700 series PECVD system. The models obtained will ultimately be used for several other manufacturing applications, including recipe synthesis and process control.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>