gebhart/patrepeval huggingface dataset:
Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130 (2002)

IL-6 is a multifunctional cytokine involved in regulation of differentiation, antibody production, and growth of certain types of tumor cells. Its excessive production plays a major role in pathogenesis of multiple myeloma and postmenopausal osteoporosis. In the course of a screening program aimed at IL-6 inhibitor from microbial products, we found madindoline A (MDL-A) and madindoline B, which have a fuloindoline structure with diketocyclopentene bound to the methyl group. MDL-A has no cytotoxic activities. It inhibited only activities of both IL-6 and IL-11 without affecting the IL-6-specific signal transduction cascade, JAK2/STAT3. In a dose-dependent manner [(3)H]MDL-A binds to gp130, which is a signal transducing 130-kDa glycoprotein, but formation of the trimeric complex IL-6/IL-6 receptor/gp130 was not inhibited, suggesting that MDL-A suppresses dimerization of trimeric complexes. Not only did MDL-A markedly inhibit IL-6- and IL-11-induced osteoclastogenesis in vitro, but it also inhibited IL-6-stimulated serum amyloid A production and bone resorption in an experimental model of postmenopausal osteoporosis in vivo by a different mechanism from that of 17beta-estradiol. Here we show that MDL-A has a highly selective inhibitory effect on IL-6 and IL-11 activities by inhibiting a gp130 activity while suppressing bone loss in ovariectomized mice. MDL-A is anticipated as a lead compound for treatment of hormone-dependent postmenopausal osteoporosis, which has no serious side effects, and as a new mechanism of action, gp130 blocking.
Long-Term Effect of a Urinary Chemosignal on Reproductive Fitness in Female Mice (1993)

The effect of synthetic 2,5-dimethylpyrazine (a compound naturally produced by grouped females) on the overall reproductive success of female mice was investigated. The exposure of tested females to control or experimental stimuli began on the day of birth and lasted throughout maturation, mating, pregnancy, and the lactating of their first litters. Females exposed to this urinary compound attained their first estrus significantly later than the animals exposed to water only. On average, the prepubertal, exposed females reached puberty 3.7 to 3.9 days later than the unexposed animals. The females in which puberty was delayed by this synthetic chemosignal did not show a single fully completed estrous cycle before the age of 35 days. Only 52-64% of exposed females successfully bred and reared their litters as compared to 86-96% of the unexposed, control females (p < 0.05). A significantly higher mortality of pups associated with 2,5-dimethylpyrazine exposure during lactation was observed. The reproductive deficit displayed by females born into a 2,5-dimethylpyrazine environment is qualitatively similar to the effect observed in dense populations, in both laboratory and free-living conditions.
Minimally Invasive Revision Total Knee Arthroplasty (2006)

Therapeutic study, level IV (retrospective case series). See the Guidelines for Authors for a complete description of levels of evidence.
Fast blind inverse halftoning (2002)

We present a fast, non-iterative technique for producing grayscale images from error diffused and dithered halftones. The first stage of the algorithm consists of a Gaussian filter and a median filter, while the second stage consists of a bandpass filter, a thresholding operation, and a median filter. The second stage enhances the rendering of edges in the inverse halftone. We compare our algorithm to the best reported statistical smoothing, wavelet, and Bayesian algorithms to show that it delivers comparable PSNR and subjective quality at a fraction of the computation and memory requirements. For error diffused halftones, our technique is seven times faster than the MAP estimation method and 75 times faster than the wavelet method. For dithered halftones, our technique is 200 times faster than the MAP estimation method. A C implementation of the algorithm is available.
Distributed-directory scheme: scalable coherent interface (1990)

The scalable coherent interface (SCI), a local or extended computer backplane interface being defined by an IEEE standard project (P1596), is discussed. the interconnection is scalable, meaning that up to 64 K processor, memory, or I/O nodes can effectively interface to a shared SCI interconnection. The SCI sharing-list structures are described, and sharing-list addition and removal are examined. Optimizations being considered to improve the performance of large system configurations are discussed. Request combining, a useful feature of linked-list coherence, is described. SCI's optional extensions, including synchronization using a queued-on-lock bit, are considered.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Highly Photocatalytically Active Iron(III) Titanium Oxide Thin films via Aerosol‐Assisted CVD (2014)

Abstract This paper presents, for the first time, the synthesis, via aerosol‐assisted (AA)CVD followed by annealing at 620 °C for 5 h, of pure Fe 2 TiO 5 thin films on glass. The thin film is deposited from a one pot solution containing titanium isopropoxide and tris(acetylacetonato)iron in an ethyl acetate solvent. The film is characterized using a range of techniques including powder X‐ray diffraction(XRD), wavelength dispersive X‐ray (WDX) spectroscopy, X‐ray photoelectron spectroscopy(XPS), scanning electron microscopy (SEM), and UV‐vis spectroscopy. The photocatalytic activity of the film under UVA and visible light irradiation is also tested. The results show that Fe 2 TiO 5 is able to degrade resazurin redox dye under UVA illumination at a rate much higher than Pilkington NSG Activ TM , with a formal quantum efficiency (FQE) an order of magnitude superior.
A new polymorphic probe on chromosome 3p: λLIB33–29′ (D3S629) (1991)

A new polymorphic probe on chromosome 3p: λLIB33–29′ (D3S629) Get access F. Latif, F. Latif Search for other works by this author on: Oxford Academic PubMed Google Scholar G.M. Glenn, G.M. Glenn Search for other works by this author on: Oxford Academic PubMed Google Scholar H. Brauch, H. Brauch Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Delisio, J. Delisio 1Progam Resources Inc., Frederick Cancer Research and Development CenterFrederick, MD 21701, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar K. Hampsch, K. Hampsch 1Progam Resources Inc., Frederick Cancer Research and Development CenterFrederick, MD 21701, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar M.L. Orcutt, M.L. Orcutt Search for other works by this author on: Oxford Academic PubMed Google Scholar B. Zbar, B. Zbar Search for other works by this author on: Oxford Academic PubMed Google Scholar M.I. Lerman M.I. Lerman * * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 19, Issue 4, 25 February 1991, Page 964, https://doi.org/10.1093/nar/19.4.964 Published: 25 February 1991
Phylogeny of genes for secretion NTPases: Identification of the widespread tadA subfamily and development of a diagnostic key for gene classification (2001)

Macromolecular transport systems in bacteria currently are classified by function and sequence comparisons into five basic types. In this classification system, type II and type IV secretion systems both possess members of a superfamily of genes for putative NTP hydrolase (NTPase) proteins that are strikingly similar in structure, function, and sequence. These include VirB11, TrbB, TraG, GspE, PilB, PilT, and ComG1. The predicted protein product of tadA, a recently discovered gene required for tenacious adherence of Actinobacillus actinomycetemcomitans, also has significant sequence similarity to members of this superfamily and to several unclassified and uncharacterized gene products of both Archaea and Bacteria. To understand the relationship of tadA and tadA-like genes to those encoding the putative NTPases of type II/IV secretion, we used a phylogenetic approach to obtain a genealogy of 148 NTPase genes and reconstruct a scenario of gene superfamily evolution. In this phylogeny, clear distinctions can be made between type II and type IV families and their constituent subfamilies. In addition, the subgroup containing tadA constitutes a novel and extremely widespread subfamily of the family encompassing all putative NTPases of type IV secretion systems. We report diagnostic amino acid residue positions for each major monophyletic family and subfamily in the phylogenetic tree, and we propose an easy method for precisely classifying and naming putative NTPase genes based on phylogeny. This molecular key-based method can be applied to other gene superfamilies and represents a valuable tool for genome analysis.
Design and Analysis of G4 Recognition Compounds (2002)

This chapter contains sections titled: Introduction Telomeric DNA Crystal Structures of G-quadruplexes The d(TG4T) Quadruplex The Na+ form of d(G4T4G4) Oxytricha nova Telomeric DNA The K+ form of d(G4T4G4) Oxytricha nova Telomeric DNA The Crystal Structure of the Human Telomere G-quadruplex The r(UG4U) RNA Quadruplex NMR Studies of Quadruplexes Quadruplex-binding Ligands NMR and Modeling Studies of Quadruplex–Ligand Complexes
Electrical field-induced faceting of etched features using plasma etching of fused silica (2017)

This paper reports a previously unreported anomaly that occurs when attempting to perform deep, highly anisotropic etches into fused silica using an Inductively-Coupled Plasma (ICP) etch process. Specifically, it was observed that the top portion of the etched features exhibited a substantially different angle compared to the vertical sidewalls that would be expected in a typical highly anisotropic etch process. This anomaly has been termed as “faceting.” A possible explanation of the mechanism that causes this effect and a method to eradicate it has been developed. Additionally, the method to eliminate the faceting is demonstrated. It is theorized that this faceting is a result of the interaction of the electro-potential electrical fields that surround the patterned nickel layers used as a hard mask and the electrical fields directing the high-energy ions from the plasma to the substrate surface. Based on this theory, an equation for calculating the minimum hard mask thickness required for a desired etch depth into fused silica to avoid faceting was derived. As validation, test samples were fabricated employing hard masks of thicknesses calculated based on the derived equation, and it was found that no faceting was observed on these samples, thereby demonstrating that the solution performed as predicted. Deep highly anisotropic etching of fused silica, as well as other forms of silicon dioxide, including crystalline quartz, using plasma etching, has an important application in the fabrication of several MEMS, NEMS, microelectronic, and photonic devices. Therefore, a method to eliminate faceting is an important development for the accurate control of the dimensions of deep and anisotropic etched features of these devices using ICP etch technology.
Quantification of Supramolecular Complexes Involving Charged Species in Non-Aqueous Solvents: Theory and Application (2004)

We report for the first time a broad equilibrium model describing the complexation of ionic species in non-aqueous media that explicitly includes ion pairing for one of the components and that relies upon activities rather than molar concentrations. This model directly contradicts existing commonplace equilibrium treatments, which were shown to be incomplete, often invalid, and misleading. Experimental validation of our model was achieved through studies of pseudorotaxane formation between dibenzylammonium salts (DBAm-X) and dibenzo-24-crown-8 (DB24C8) in CDCl3:CD3CN (3:2). In that particular case, we showed that fluctuations in the apparent Ka,exp values as usually reported are attributable to ion pairing, with a dissociation constant Kipd, and that the constant Kassoc for pseudorotaxane complexation is independent of the counterion, a result of the complex existing in solution as a free cation. In accord with this model, we further described a straightforward and simple method to increase the extent of complexation by using either a ditopic cation and anion host, or adding to the charged host/guest solution a molecularly separate host capable of complexing the dissociated counterion. Also in accord with this model, we investigated the influence of the solventÂ¡Â¯s dielectric constant on Kipd and Kassoc. On the basis of competing condensation reactions between amines and ketones which were shown to occur within the timescale of host/guest recognition, we also challenged the commonly employed use of acetone in similar complexation studies involving 2o ammonium ions. Because a major goal of this work was to ultimately increase binding efficiency and selectivity, we explored new methods to drive complexation in related pseudorotaxane systems. We noted that addition of di- or tri-topic hydrogen bond accepting anions to solutions of bis(5-hydroxymethyl-1,3-phenylene)-32-crown-10 or bis(5-carboxy-1,3-phenylene)-32-crown-10 and paraquat di(hexafluorophosphate) served to significantly enhance host/guest interaction. The addition of Et4N+TFA- to an acetone solution of diacid crown and paraquat 2PF6 effectively boosted Ka,exp 40-fold, as estimated by 1H NMR studies. Similar increases in the apparent Ka,exp were observed upon the addition of n-Bu4N+OTs-. Evidenced by crystal structures, the increase in association resulted from chelation of the OH moieties of the crown by the di- or tri-topic anions, forming supramolecular bicyclic macrocycles (pseudocryptands) and stabilizing the complex in a cooperative manner. Significantly, Ka,exp of one of the pseudocryptands was shown to equal that determined in the corresponding cryptand complex.
Toward a better understanding of strain incompatibilities at grain boundaries in the analysis of fatigue crack initiation at low temperature in the UdimetTM720 Li superalloy (2014)

Low cycle fatigue properties of polycrystalline γ-γ′ Ni-based superalloys are dependent on many factors such as temperature, environment, grain size and distribution of the strengthening phases. Under LCF conditions at intermediate temperatures, an intergranular crack initiation could be observed. In this paper we propose to analyze the local conditions favouring such an intergranular cracking mode considering the high strength C&W UdimetTM720 Li alloy, widely used for manufacturing high pressure turbine disk for aeroengine applications. Tensile and fatigue tests were performed in air in the 20–465 ∘C range of temperature on micro-samples in order to focus on plasticity and damage processes developed near grain boundaries. A special attention was paid on the slip transfer between neighbouring grains taking into account their local crystallographic orientations. In some specific crystallographic configurations, small zones were detected at the tip of slip bands presenting an intense elastic/plastic activity. Although they are limited in size, they are associated to local crystalline rotations. High levels of local strain/stress were also evaluated in these volumes using an EBSD pattern cross correlation technique. The development of such specific zones was investigated at different stages of the tensile and LCF behaviour and was identified as leading to micro-cracks initiation for both solicitation modes.
Synthesis of Angiotensins by the Solid-Phase Method* (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Angiotensins by the Solid-Phase Method*Garland R. Marshall and R. B. MerrifieldCite this: Biochemistry 1965, 4, 11, 2394–2401Publication Date (Print):November 1, 1965Publication History Published online1 May 2002Published inissue 1 November 1965https://pubs.acs.org/doi/10.1021/bi00887a020https://doi.org/10.1021/bi00887a020research-articleACS PublicationsRequest reuse permissionsArticle Views312Altmetric-Citations143LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Oral Omilancor Treatment Ameliorates Clostridioides difficile Infection During IBD Through Novel Immunoregulatory Mechanisms Mediated by LANCL2 Activation (2023)

These data support the development of omilancor as a novel host-targeted, antimicrobial-free immunoregulatory therapeutic for the treatment of IBD patients with C. difficile-associated disease and pathology with the potential to address the unmet clinical needs of ulcerative colitis and Crohn's disease patients with concomitant CDI.
Constraint Enforcement via Tube-Based MPC Exploiting Switching Restrictions (2021)

Dwell-time restrictions are critical to overcoming infeasibility caused by arbitrary switches in constrained time-dependent switched systems, especially when the system equilibrium is mode dependent. However, existing approaches to enforce constraints are not applicable in presence of disturbances. In this paper, a recursively feasible switched tube-based MPC (TMPC) is designed for constrained linear modes subject to polytopic-bounded additive disturbances. Control-invariant sets that are robust to mode switches and disturbances are proposed to select terminal constraints and identify feasible initial states. The method is distinguished by the admission of mode-dependent equilibria, user-specified prediction horizons, non-reliance on a preview of the switching signal, and online computations equal to that of a non-switched TMPC.
Trends in Carbon, Oxygen, and Nitrogen Core in the X-ray Absorption Spectroscopy of Carbon Nanomaterials: A Guide for the Perplexed (2020)

Successful deployment of carbon nanomaterials in many applications, such as sensing, energy storage, and catalysis, relies on the selection, synthesis, and tailoring of the surface properties. Predictive analysis of the behavior is difficult without detailed knowledge of the differences between various carbon nanomaterials and their surface functionalization, thus leaving the selection process to traditional trial-and-error work. The present characterization fills this knowledge gap for carbon nanomaterial surface properties with respect to chemical states and functionalization. We present an overview of the chemical trends that can be extracted from soft X-ray absorption spectroscopy (XAS) spectra on an extended set of nonideal carbon nanomaterials as a function of sp² bonded carbon and bond ordering. In particular, the surface chemical state, the presence of long-range order in the carbon matrix, and a qualitative estimation of the amount of oxygen and nitrogen and their respective functional group formation on the material surface, together with the detailed material fabrication parameters, are reported. The results expand our understanding of carbon nanomaterial functionalization, which can support material selection in practice, provided that the specifications of the application are known.
Shaping reverberating sound fields with an actively tunable metasurface (2018)

A reverberating environment is a common complex medium for airborne sound, with familiar examples such as music halls and lecture theaters. The complexity of reverberating sound fields has hindered their meaningful control. Here, by combining acoustic metasurface and adaptive wavefield shaping, we demonstrate the versatile control of reverberating sound fields in a room. This is achieved through the design and the realization of a binary phase-modulating spatial sound modulator that is based on an actively reconfigurable acoustic metasurface. We demonstrate useful functionalities including the creation of quiet zones and hotspots in a typical reverberating environment.
Heteroflocculation in Binary Colloidal Suspensions: Monte Carlo Simulations (1996)

We have examined heteroflocculation in binary colloidal suspensions by Monte Carlo simulations based on a diffusion‐limited‐cluster‐aggregation (DLCA) model modified with finite attraction energies. The simulations were performed in two dimensions. Under heteroflocculation conditions, i.e., attraction between unlike particles and repulsion between like particles, cluster size undergoes a maximum as the concentration of the second species of particles is increased, similar to the experimental results in both binary suspensions and suspensions with adsorbing polymers. The initial increase in cluster size at low concentrations of the second species of particles is due to the mutual attraction between unlike particles. The decrease in cluster size at higher concentrations of the second species of particles is due to the repulsion between the second species of particles. The distinction between heteroflocculation and particulate depletion flocculation is discussed.
Time-Dependent Leakage Current Behavior of Integrated Ba0.7Sr0.3TiO3 Thin Film Capacitors during Stressing (1996)

Time-dependent leakage current behavior of integrated Ba 0.7 Sr 0.3 TiO 3 capacitors accelerated by stresses in excess of operating temperature and voltage was studied. Current-voltage ( J - V ) studies revealed that the time-dependent leakage current behaviors are different according to the initial conduction process. When the initial leakage current of a fully processed integrated capacitor at high voltages at elevated temperatures is of the Frenkel-Poole emission type, the leakage current increases rapidly with time. The difference in the initial leakage currents is related to the difference in film growth conditions which determine the formation of defects in the films. The time-dependent increase in leakage current is ascribed to a change in the conduction mechanism from the interface-controlled Schottky type to the bulk-related space-charge-limited type due to the accumulation of oxygen vacancies near the cathode as a result of interface barrier lowering and the migration of distributed oxygen vacancies across the film.
Highly sensitive, low-power, 10-20Gb/s transimpedance amplifier based on cascaded CMOS inverter gain stages (2014)

Error-free operation is demonstrated up to 20Gb/s for a TIA consisting of seven cascaded inverter-based gain stages in 40nm (LP) CMOS technology, with a current sensitivity of 70μA and an energy efficiency of 575fJ/b.