gebhart/patrepeval huggingface dataset:
Effect of copper on recombinant mouse prion protein (2000)

Conference Abstract| February 01 2000 Effect of copper on recombinant mouse prion protein Boon-Seng Wong; Boon-Seng Wong 1NERC Institute of Virology, Oxford, OX1 3SR, UK Search for other works by this author on: This Site PubMed Google Scholar David R. Brown; David R. Brown †Biochemistry Department, Cambridge University, Cambridge, CB2 1QW, UK Search for other works by this author on: This Site PubMed Google Scholar Christine Clive; Christine Clive ‡Chemistry Department, Hull University, Hull, HU6 7RX, UK Search for other works by this author on: This Site PubMed Google Scholar Steve Haswell; Steve Haswell ‡Chemistry Department, Hull University, Hull, HU6 7RX, UK Search for other works by this author on: This Site PubMed Google Scholar Man-Sun Sy; Man-Sun Sy ¶Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH4412, USA Search for other works by this author on: This Site PubMed Google Scholar Pierluigi Gambetti; Pierluigi Gambetti ¶Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH4412, USA Search for other works by this author on: This Site PubMed Google Scholar R. Anthony Williamson; R. Anthony Williamson §Immunology Department, Scripps Research Institute, La Jolla, CA92037, USA Search for other works by this author on: This Site PubMed Google Scholar Dennis R. Burton; Dennis R. Burton §Immunology Department, Scripps Research Institute, La Jolla, CA92037, USA Search for other works by this author on: This Site PubMed Google Scholar Ian M. Jones Ian M. Jones 1NERC Institute of Virology, Oxford, OX1 3SR, UK Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (2000) 28 (1): A36. https://doi.org/10.1042/bst028a036b Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation Boon-Seng Wong, David R. Brown, Christine Clive, Steve Haswell, Man-Sun Sy, Pierluigi Gambetti, R. Anthony Williamson, Dennis R. Burton, Ian M. Jones; Effect of copper on recombinant mouse prion protein. Biochem Soc Trans 1 February 2000; 28 (1): A36. doi: https://doi.org/10.1042/bst028a036b Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2000 Biochemical Society2000 Article PDF first page preview Close Modal You do not currently have access to this content.
Hydrazine Sensor for Quantitative Determination of High Hydrazine Concentrations for Direct Hydrazine Fuel Cell Vehicle Applications (2013)

With the discovery of hydrazine as an alternative to hydrogen fuel for the development of fuel cell electric vehicles (FCEV), the need for a hydrazine sensor for the quantitative determination of hydrazine aroused. In contrast to the common hydrazine electrochemical sensors whose main parameters are the low detection and quantification limits, the new electrochemical sensor should satisfy one main requirement: a linear response at high hydrazine concentrations (2-4 M hydrazine). In this study, three types of catalysts were tested for hydrazine oxidation and its electrochemical quantitative determination: Ni0.87Zn0.13, Ni0.95La0.05 and Ni0.85La0.15. Layer-by-layer composites based on the utilization of Ni1-xLax catalyst and diffusion control layer (DCL) were successfully explored in the development of the hydrazine sensor. Ni1-xLax-DCL composites produced a linear response for hydrazine concentrations within 2-4 M, with the highest sensitivity observed from bilayer Ni0.95La0.05-DCL electrodes (13.2 μA M−1 N2H4 or 53.3 μA/M.cm2 N2H4). An alternative approach for the development of a FCEV-hydrazine sensor was also demonstrated. A flow-through sensor with Ni0.95La0.05-RVC (reticulated vitreous carbon) electrode, operating in a constant flow of 1.2 mL/min was designed. The sensor showed current/hydrazine concentration linear dependence in the range 0.05–5 M hydrazine with a correlation coefficient of 0.9999. The sensitivity of the sensor was 31.696 mA/M·g with a limit of detection and a limit of quantitation 0.14 M and 0.72 M, respectively. The uncertainty of the hydrazine concentration was determined to be 4.68% at the middle of the calibration curve.
Rapid Antibody-Based Field Test To Distinguish Between <I>Helicoverpa armigera</I> (Lepidoptera: Noctuidae) and <I>Helicoverpa punctigera</I> (Lepidoptera: Noctuidae) (2000)

Helicoverpa armigera (Hübner) and Helicoverpa punctigera (Wallengren) are the two most important insect pests of cotton production in Australia and require application of insecticides to control them. H. armigera has developed resistance to several insecticides but H. punctigera has not. Cost-effective management of insecticide resistance requires that growers be able to determine the proportion of H. armigera eggs or young larvae present on their crop before applying insecticides. This is impossible visually. We generated two monoclonal antibodies that reacted with the insect protein "lipophorin" and were capable of discriminating individuals of the two species at all life-stages. The antibodies were incorporated into a rapid test kit that was tested under field conditions over two growing seasons. Results obtained with the kit agreed closely with those obtained by rearing larvae through to second instar.
A Fast Renormalization Technique for H.264/MPEG4-AVC Arithmetic Coding (2006)

The authors propose a fast, standard-compliant realization of the computationally expensive renormalization part of binary arithmetic coding in H.264/MPEG4 advanced video coding (AVC). Their technique allows to replace time-consuming, bitwise-operating input and output as well as bitwise carry-over handling in a conventional implementation with corresponding routines operating in units of multiple bits. Experimental results demonstrate that the authors' proposed method enables a considerable speed-up of both arithmetic encoding and decoding in the range of 24 to 53 % average run time.
Impact of Interchannel Nonlinearities on a Split-Step Intrachannel Nonlinear Equalizer (2010)

We experimentally investigate the use of split-step intrachannel nonlinear equalizer, for a wavelength-division-multiplexed (WDM) 112-Gb/s nonreturn-to-zero polarization-division-multiplexed quadri-phase-shift keying system using a digital coherent receiver. Our investigations demonstrate that the nonlinear compensation algorithm can increase the reach by 23% in a 100-GHz spacing WDM link compared to 46% for the single-channel case. When the channel spacing is reduced to 50 GHz, the reach improvement is minimal due to the uncompensated interchannel nonlinearities; nevertheless, the system robustness is improved as the system operating power dynamic range is widened by 2 dB.
Identifying Best Interventions through Online Importance Sampling (2017)

Motivated by applications in computational advertising and systems biology, we consider the problem of identifying the best out of several possible soft interventions at a source node $V$ in an acyclic causal directed graph, to maximize the expected value of a target node $Y$ (located downstream of $V$). Our setting imposes a fixed total budget for sampling under various interventions, along with cost constraints on different types of interventions. We pose this as a best arm identification bandit problem with $K$ arms where each arm is a soft intervention at $V,$ and leverage the information leakage among the arms to provide the first gap dependent error and simple regret bounds for this problem. Our results are a significant improvement over the traditional best arm identification results. We empirically show that our algorithms outperform the state of the art in the Flow Cytometry data-set, and also apply our algorithm for model interpretation of the Inception-v3 deep net that classifies images.
Genetic and Targeted eQTL Mapping Reveals Strong Candidate Genes Modulating the Stress Response During Chicken Domestication (2017)

The stress response has been largely modified in all domesticated animals, offering a strong tool for genetic mapping. In chickens, ancestral Red Junglefowl react stronger both in terms of physiology and behavior to a brief restraint stress than domesticated White Leghorn, demonstrating modified functions of the hypothalamic-pituitary-adrenal (HPA) axis. We mapped quantitative trait loci (QTL) underlying variations in stress-induced hormone levels using 232 birds from the 12th generation of an advanced intercross between White Leghorn and Red Junglefowl, genotyped for 739 genetic markers. Plasma levels of corticosterone, dehydroepiandrosterone (DHEA), and pregnenolone (PREG) were measured using LC-MS/MS in all genotyped birds. Transcription levels of the candidate genes were measured in the adrenal glands or hypothalamus of 88 out of the 232 birds used for hormone assessment. Genes were targeted for expression analysis when they were located in a hormone QTL region and were differentially expressed in the pure breed birds. One genome-wide significant QTL on chromosome 5 and two suggestive QTL together explained 20% of the variance in corticosterone response. Two significant QTL for aldosterone on chromosome 2 and 5 (explaining 19% of the variance), and one QTL for DHEA on chromosome 4 (explaining 5% of the variance), were detected. Orthologous DNA regions to the significant corticosterone QTL have been previously associated with the physiological stress response in other species but, to our knowledge, the underlying gene(s) have not been identified. <i>SERPINA10</i> had an expression QTL (eQTL) colocalized with the corticosterone QTL on chromosome 5 and <i>PDE1C</i> had an eQTL colocalized with the aldosterone QTL on chromosome 2. Furthermore, in both cases, the expression levels of the genes were correlated with the plasma levels of the hormones. Hence, both these genes are strong putative candidates for the domestication-induced modifications of the stress response in chickens. Improved understanding of the genes associated with HPA-axis reactivity can provide insights into the pathways and mechanisms causing stress-related pathologies.
Stereoselective Synthesis of Trisubstituted (E,E)-1,3-Dienes by the Site-Selective Reductive Cross-Coupling of Internal Alkynes with Terminal Alkynes: A Fragment Coupling Reaction for Natural Product Synthesis (2009)

A highly selective convergent coupling reaction is described between alkynes for the synthesis of stereodefined trisubstituted (E,E)-1,3-dienes-structural motifs commonly found embedded in the skeletons of bioactive polyketide-derived natural products. While numerous multistep processes for the synthesis of this stereodefined functional group exist, the current method represents a significant advance as it does not require stereodefined olefinic coupling partners (vinyl halide or vinyl organometallic); it proceeds by a single convergent C-C bond-forming event (avoiding multistep methods based on carbonyl olefination) and is tolerant of a diverse array of functional groups including free hydroxyls. Through a systematic study of titanium-mediated reductive cross-coupling reactions of internal alkynes with terminal alkynes, a fragment coupling reaction of great utility in natural product synthesis has emerged. Here, use of a proximal hydroxy group to control regioselection in the functionalization of a preformed titanacyclopropene has led to the establishment of a highly selective bimolecular coupling process, where C-C bond formation occurs in concert with the establishment of two stereodefined alkenes. Compared to the body of literature known for related metal-mediated coupling reactions, the current work defines a powerful advance, achieving site-selective bimolecular C-C bond formation without the need for using TMS-alkynes or conjugated alkynes. Overall, complex 1,3-dienes relevant for the synthesis of polyketide-derived natural products of varying stereochemistry were prepared with typically >or=20:1 selectivity, defining the important role of an alkoxide directing group located delta to preformed titanacyclopropenes.
Adsorption of O2on a (4, 2) carbon nanotube (2007)

The physisorption and chemisorption of O-2 on the outer wall of a ( 4, 2) carbon nanotube have been studied by density functional calculations. The minimum-energy paths from physisorbed products to chemisorbed products are calculated by the nudged elastic band technique. Our theoretical calculations and experimentally measured Raman spectra both indicate that the ( 4, 2) tube is less air stable than the (5, 0) tube, which could be used to select a single chirality from a mixture of these 4 angstrom tubes.
Patient Flow in Peri-Operative Services: Analysis of Factors that Impact OR Turn Over Time (2020)

Introduction: The University Campus of UMass Memorial Medical Center has 16 operating rooms. The average Turn Over Time (TOT), defined as patient out of OR to next patient in, is 43 minutes. This is a source of dissatisfaction for the surgeons and has an impact on the patient experience. We did an observational study to map and time patient flow from the Surgical Admission Unit (SACU) to the Operating Room and the process for OR turn over and arrival of the next patient. The goal was to assess how the process could be modified to enhance the patient experience and improve surgeon satisfaction. Methods: Observation and hand recording of three rooms in the University OR was performed from 6/13/2011 – 8/5/2011 (Orthopedic and Neurosurgery cases). Time points for all processes directly involving the patient were collected. Data collection was done by three undergraduate students. Support for the students was provided by Orthopedics, Anesthesiology and Peri-Operative Services. Results: See Figure 1 for patient flow and turn over process map. Subsequent figures show time intervals from SACU to OR case completion, call for cleaning, completion of cleaning and arrival of next patient. Cleaning was complete in 18 minutes but TOT was 43 minutes because nondependent tasks were being performed in series (Figure 5). Summary: Nondependent tasks are being performed in series in the SACU and during OR turn over. There is an opportunity to decrease patient length of stay in the SACU. By doing parallel practice OR TOT can be decreased from 43 to 19 minutes if the anesthesia team is allowed to bring the patient in the room once the room is clean. This process can enhance the patient experience and improve surgeon satisfaction.
Edmund H. Sonnenblick (2004)

Braunwald, where these basic studies were extended to the intact heart, both in experimental
Polysynchronous Clocking: Exploiting the Skew Tolerance of Stochastic Circuits (2017)

In the paradigm of stochastic computing, arithmetic functions are computed on randomized bit streams. The method naturally and effectively tolerates very high clock skew. Exploiting this advantage, this paper introduces polysynchronous clocking, a design strategy in which clock domains are split at a very fine level. Each domain is synchronized by an inexpensive local clock. Alternatively, the skew requirements for a global clock distribution network can be relaxed. This allows for a higher working frequency and so lower latency. The benefits of both approaches are quantified. Polysynchronous clocking results in significant latency, area, and energy savings for wide variety of applications.
Control over bandlimited communication channels: intersampling performance (2005)

Most networked sampled data control systems involve transmission of feedback and actuation signals over finite bandwidth communication channels. In an earlier paper, [S. Dasgupta, 2003] we had demonstrated that this restriction on the transmission bandwidth severely impairs stabilizability should the sampling rate exceed the Nyquist frequency of the communication channels conveying the feedback and actuation signals. In this paper we examine the effect of such bandwidth limitation to the intersample behavior of the closed loop system. While it is well known that slower sampling degrades intersample performance [J.S. Freudenberg et al., 1995] in the presence of delays, the results here quantify the severe performance degradation when the sampling is too fast.
ChemInform Abstract: SOLID PHASE AND SOLUTION PHOTOCHEMISTRY OF COUMALATE ESTERS (1977)

Abstract Solid Phase and Solution Photochemistry of Coumalate Esters.
Standardization of Hemiarthroplasty for Femoral Neck Fracture (2010)

当科では手術の安全性・確実性の確保と効率化を目的に，2009年4月より手術の標準化へ取り組んできた．今回，大腿骨頚部骨折に対する人工骨頭挿入術を例に我々の取り組みとその成果を報告する．取り組みとしてはこれまで術者の好みに任せていた使用機種を可能な限り統一し手術手技を標準化した．標準化取り組み前に行われた人工骨頭挿入術17例と取り組み後の13例の成績を調査した．手術時間，手術室滞在時間は短縮し術中出血も減少した．取り組み後，合併症は認めなかった．手術の標準化は決して容易ではないが取り組む価値があると思われた．
Stereocontrolled Dopamine Receptor Binding and Subtype Selectivity of Clebopride Analogues Synthesized from Aspartic Acid. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
A Taxonomy of Secure Two-Party Comparison Protocols and Efficient Constructions (2019)

Secure two-party comparison plays a crucial role in many privacy-preserving applications, such as privacy-preserving data mining and machine learning. In particular, the available comparison protocols with the appropriate input/output configuration have a significant impact on the performance of these applications. In this paper, we firstly describe a taxonomy of secure two-party comparison protocols which allows us to describe the different configurations used for these protocols in a systematic manner. This taxonomy leads to a total of 216 types of comparison protocols. We then describe conversions among these types. While these conversions are based on known techniques and have explicitly or implicitly been considered previously, we show that a combination of these conversion techniques can be used to convert a perhaps less-known two-party comparison protocol by Nergiz et al. (IEEE SocialCom 2010) into a very efficient protocol in a configuration where the two parties hold shares of the values being compared, and obtain a share of the comparison result. This setting is often used in multi-party computation protocols, and hence in many privacy-preserving applications as well. We furthermore implement the protocol and measure its performance. Our measurement suggests that the protocol outperforms the previously proposed protocols for this input/output configuration, when off-line pre-computation is not permitted.
Adding Insulin Glargine Versus Rosiglitazone (2007)

Although addition of insulin glargine and rosiglitazone achieved comparable improvements in glycemic control, insulin glargine was associated with greater improvements in HRQOL, indicating that other factors (e.g., safety profile and nonglycemic actions) may further enhance HRQOL in patients with type 2 diabetes.
Fetal manifestations and poor outcomes of congenital cytomegalovirus infections: Possible candidates for intrauterine antiviral treatments (2007)

The absence of abdominal signs guarantees the infant's survival. The presence of abdominal or cerebral signs is associated with poor outcomes, suggesting that these fetuses are possible candidates to receive in-utero therapy of congenital CMV infection.
Untersuchungen zur asymmetrischen, Iridium-katalysierten Hydrierung konjugierter Diene und Anwendungen in der Naturstoffsynthese (2012)

Komplex Herstellung. Zwei neue Ligandenklassen wurden hergestellt und in der Iridium-katalysierten asymmetrischen Hydrierung getestet. Ausgehend von R,R- und S,S-Diphenylethylendiamin verbunden mit verschiedenen chiralen Pyridinylalkoholen wurden zwölf verschiedene Diazaphospholidin-Liganden hergestellt und zu Iridium-Komplexen umgesetzt. Diese Komplexe wurden in der Hydrierung von verschiedenen unfunktionalisierten und funktionalisierten Alkenen, besonders aber für alpha, beta-ungesättigte Carbonsäureester, getestet. Die Hydrierungen der verschiedenen Alkene waren sehr erfolgreich, sie lieferten Enantiomerenüberschüsse von bis zu 99%. Bei alpha-methylierten alpha, beta-ungesättigten Carbonsäureestern mit verschiedenen Substituenten in der beta-Position ergaben die Hydrierungen über 90% ee. Für die beta-methylierten Carbonsäureester lieferten die neuen Iridium-Komplexe bis zu 97% ee.&#13;\n&#13;\nDie Entwicklung und Herstellung von neuen P,N-Liganden, welche auf Imidazolinen basieren, wurde als nächstes untersucht. Strukturell ähnliche Oxazolin-Liganden wurden durch Imidazoline ersetzt. Durch das zusätzliche Stickstoffatom kännen die elektronischen und sterischen Eigenschaften der Liganden modifiziert werden. Eine erfolgreiche Syntheseroute zur Herstellung der Imidazolin-Iridium-Komplexe wurde entwickelt. Allerdings waren die Hydrierungen mit den neuen Imidazolin-Iridium-Komplexen eher unbefriedigend.&#13;\n&#13;\nEine Verbesserung der Imidazolin-Liganden gelang, indem man den aromatischen Ring am Stickstoffatom durch eine Sulfonyl-Gruppe ersetzte. Es wurde eine neue Syntheseroute für diese Ligandenklasse entwickelt und es konnten somit vier neue Sulfonyl-Imidazolin-Iridium-Komplexe hergestellt und in der asymmetrischen Hydrierung getestet werden. Die Hydrierungen von verschiedenen unfunktionalisierten und funktionalisierten Alkenen lieferten Enantiomerenüberschüsse von über 90%.&#13;\n&#13;\nAnwendung in Naturstoff- und Wirkstoffsynthesen. Der zweite Teil dieser Arbeit war die Anwendung der Iridium-katalysierten asymmetrischen Hydrierung zur Herstellung von biologisch wichtigen Naturstoffen. Bei einer Zusammenarbeit mit Prof. J. Mulzer (Universität Wien, …sterreich) wurde eine asymmetrische Synthese für Platensimycin entwickelt. Die geplante Syntheseroute beinhaltete die asymmetrische Hydrierungen von zwei Zwischenstufen, welche erfolgreich mit exzellenten Umsätzen und Enantioselektivitäten erreicht wurden. Dabei lieferte der Iridium-Komplex 67c die besten Ergebnisse. Die Zwischenstufe konnte mit einer geringen Katalysatorbeladung und im Gramm-Ma§stab umgesetzt werden.&#13;\n&#13;\nDas nächste Projekt war die Synthese von Aliskiren. Dabei wurden verschiedene Ester hergestellt und in der Iridium-katalysierten asymmetrischen Hydrierung getestet. Nach einer ausgiebigen Suche für einen geeigneten Katalysator lieferte der PHOX-Komplex 28a und der PHIM-Komplex 134a für den tert-Butylester vollständigen Umsatz und 99% ee.&#13;\n