gebhart/patrepeval huggingface dataset:
Abstract 1106: Co-administration of the iRGD tumor-penetrating peptide improves the tumor immunostimulatory effects of low-dose IL-2 (2019)

Background: Recombinant IL-2 at high doses is an effective immunotherapy treatment for various types of solid tumors. However, its clinical utility has been limited by serious mechanism-based side-effects. The clinical-stage iRGD peptide specifically targets tumors and, via activation of the ‘CendR’ trans-tissue transport pathway, increases tumor penetration and accumulation of various types of co-administered drugs. By selectively increasing the drug delivery into tumors, but not to normal tissues, iRGD potentiates the pharmacological activity of various anti-cancer agents within tumor tissue, while reducing their toxicities. In this study we investigate whether co-administration of iRGD with low-dose IL-2 can improve the tumor immune microenvironment by increasing in the ratios of tumor-killing effector CD8 cells vs. the immunosuppressive T-regulatory cells.Methods: Subcutaneous breast tumors (4T1) were generated in immunocompetent mice. Mice were treated with either vehicle control, iRGD, IL-2, or IL-2 + iRGD for 5 days. Tumors were preserved for immunohistochemistry (IHC) or enzymatically digested for fluorescence activated cell sorting (FACS) 16 hours after the last dosing. The FACS and IHC panels were designed to detect the percentage of total T cells, CD4 and CD8 T cells, and Treg cells.Results: Low doses of IL-2 alone were found to increase Tregs within the tumor but had no effect in CD4 or CD8 effector T cells, compared to vehicle treatment. However, when Low dose IL-2 was co-administered with iRGD, we observed a significantly lower percentage of T regs and an increase in CD4 effector T cells. More importantly the ratio of CD8 / Treg cells was increased by at least 10-fold, compared to low dose IL-2 alone.Conclusions: The combination treatment with iRGD and low doses of IL-2 is capable of favorably altering the tumor immune microenvironment such that immunosuppressive T reg cells were reduced, while there was an increase in the effector CD4 and CD8 T-cell populations. The tumor-selective IL-2 pharmacology benefit obtained with iRGD co-administration may provide new options for the use of the well-validated IL-2 in solid tumor patients, including a strategy to overcome the primary resistance to PD-1 blockade.Citation Format: Harri Jarvelainen, Gregory P. Botta, Tatiana Hurtado De Mendoza, Erkki Ruoslahti. Co-administration of the iRGD tumor-penetrating peptide improves the tumor immunostimulatory effects of low-dose IL-2 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1106.
A Fully Integrated 10Gbps Receiver with Adaptive Optical Dispersion Equalizer in 0.13μm CMOS (2006)

A 10Gbps receiver, containing an adaptive equalizer, a clock and data recovery (CDR), and a demultiplexer, is implemented in 0.13 mum CMOS. By compensating for optical dispersion, this chip recovers transmitted data after 200km of single-mode fiber at BER < 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12 </sup> . Use of analog equalizer with digital adaptation garners total power dissipation of 950mW
Time Frequency Representation for Speech Recognition (2006)

In the field of speech recognition it has been shown that incorporating the dynamics of speech has increased recognition success. This concept is presented in Mel Frequency Cepstral Coefficients (MFCC) and its derivatives which present both the static and the dynamics of the vocal tract. In this paper, a new method for capturing the dynamic features of non-stationary speech signals is presented. The proposed approach is based upon the isolation of each cepstral band and projecting it onto orthogonal space, spanned by a set of well defined orthogonal functions. The major idea is to capture and present energy transitions between successive short term speech frames, along a non-stationary segment about 100ms. Non stationary speech segments have been represented by Time-Frequency Representations (TFR) and the analysis was modified to fit a two dimensional data. The introduced features evaluation conducted on the TIDIGIT corpus revealed an average of 58% improvement in word error rate, compared to MFCC and its derivatives in the context of isolated speech recognition in noisy environments.
Enhancing input on and above the interactive surface with muscle sensing (2009)

Current interactive surfaces provide little or no information about which fingers are touching the surface, the amount of pressure exerted, or gestures that occur when not in contact with the surface. These limitations constrain the interaction vocabulary available to interactive surface systems. In our work, we extend the surface interaction space by using muscle sensing to provide complementary information about finger movement and posture. In this paper, we describe a novel system that combines muscle sensing with a multi-touch tabletop, and introduce a series of new interaction techniques enabled by this combination. We present observations from an initial system evaluation and discuss the limitations and challenges of utilizing muscle sensing for tabletop applications.
Effect of HfO2 Crystallinity on Device Characteristics and Reliability for ReRAM (2011)

It has been investigated HfO2 crystallinity depending on the crystallinity of under layer electrode material and its effect on device characteristics and reliability for ReRAM. HfO2 on TiN electrode, which has a polycrystalline structure, shows the degradation of resistive switching characteristics possibly due to the local crystallization of HfO2 on the crystallized TiN. On the contrary, HfO2 on TiAlN electrode, which has an amorphous structure, shows the excellent switching and endurance characteristics owing to control the crystallization of HfO2.
Abstract 3232: Optimization of a potent stapled helix peptide that binds to Replication Protein A (2014)

Abstract Replication Protein A (RPA) is a major regulator of checkpoint activation and enhanced DNA repair in cancer cells. In response to genotoxic stress, the RPA complex binds to and protects ssDNA while serving as a scaffold to recruit critical checkpoint and DNA-damage response proteins through the N-terminal region of the 70 kDa subunit of RPA (RPA70N). Specific disruption of the protein-protein interactions mediated by the RPA70N domain has the potential to produce selective killing of cancer cells without the risk of cytotoxicity due to interference in the ssDNA-binding function. Stapled helix peptides can serve as useful tools for inhibiting protein-protein interactions. However, their utility can be limited due to difficulties often encountered during attempts to improve the binding affinity to the target. Here, we report the discovery and optimization of a potent stapled helix peptide probe, derived from the endogenous RPA binding partner ATRIP (ATR-interacting protein), that binds to and inhibits the RPA70N protein-protein interaction surface. Alanine scanning, charge abrogation, and rational sequence optimization resulted in a peptide with a 100-fold potency gain over the native sequence and improved physical characteristics. In addition to the application of these traditional strategies, we describe a novel approach for efficiently designing peptides containing unnatural amino acids. This method involves the incorporation of an unnatural amino acid inspired by the structure activity relationships of small molecules that bind to the same site on the protein. Use of this approach produced stapled peptides with dramatic increases in binding affinity to RPA70N relative to aooIn al peptide containing only natural amino acids. The optimized peptides are cell penetrant, able to enter the nucleus, and co-localize with RPA in the nucleus at sites of DNA damage. Such a peptide may serve as a probe molecule to explore both the effects of RPA inhibition on the DNA damage response and the therapeutic potential of RPA inhibition as a cancer target. Citation Format: Alex G. Waterson, Andreas O. Frank, Bhavatarini Vandgamudi, Michael D. Feldkamp, Elaine M. Souza-Fagundes, Jessica W. Luzwick, David Cortez, Edward T. Olejniczak, Olivia W. Rossanese, Walter J. Chazin, Stephen W. Fesik. Optimization of a potent stapled helix peptide that binds to Replication Protein A. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3232. doi:10.1158/1538-7445.AM2014-3232
Computation and Visualization of Casimir Forces in Arbitrary Geometries: Nonmonotonic Lateral-Wall Forces and the Failure of Proximity-Force Approximations (2007)

We present a method of computing Casimir forces for arbitrary geometries, with any desired accuracy, that can directly exploit the efficiency of standard numerical-electromagnetism techniques. Using the simplest possible finite-difference implementation of this approach, we obtain both agreement with past results for cylinder-plate geometries, and also present results for new geometries. In particular, we examine a pistonlike problem involving two dielectric and metallic squares sliding between two metallic walls, in two and three dimensions, respectively, and demonstrate nonadditive and nonmonotonic changes in the force due to these lateral walls.
Immunization with αDCIR.Gagp24 without adjuvant generates high titers of HIV Gagp24 antibody responses in NHPs. (2015)

&lt;p&gt;Animals were immunized i.d. three times at week 0, 6 and 15 with αDCIR.Gag24 or control hIgG4.Gagp24 or the molar equivalent of the HIV Gagp24 protein with or without poly(I:C). HIV Gagp24-specific IgG antibodies in serum were assessed at indicated time points post-immunization with αDCIR.Gagp24 or hIgG4.Gagp24 or Gagp24 without adjuvant &lt;b&gt;(A)&lt;/b&gt; or with poly(I:C) &lt;b&gt;(B)&lt;/b&gt;. Dashed lines indicates times of immunization. The serial measurements of Gagp24-specific antibody responses collected on individual monkeys over time among the vaccine groups were summarized by calculating the area under the titration curves for each monkey at each time point, and longitudinal differences between the vaccine groups were assessed by linear mixed model analysis. Data are presented as mean ± SEM. *, p&lt;0.01; **, p&lt;0.001; ***, p&lt;0.0001 compared with hIgG4.Gagp24 and Gagp24 without poly(I:C).&lt;/p&gt;
Structure–Activity Relationship Studies ofN-Methylated andN-Hydroxylated Spider Polyamine Toxins as Inhibitors of Ionotropic Glutamate Receptors (2014)

Polyamine toxins from spiders and wasps are potent open-channel blockers of ionotropic glutamate (iGlu) receptors. It is well-established that secondary amino groups in the polyamine moiety of these toxins are key to both selectivity and potency at iGlu receptors, still some native spider polyamine toxins comprise both N-methyl and N-hydroxy functionalities. Here, we investigate the effect of both N-methylation and N-hydroxylation of spider polyamine toxins by the synthesis and biological evaluation of the naturally occurring N-methylated argiopinines and pseudoargiopinines I and II, N-hydroxylated Agel-489 and Agel-505, as well as N-methylated analogues of the NMDA and AMPA iGlu receptor subtype selective antagonists ArgTX-93 and ArgTX-48. Efficient synthetic strategies for the synthesis of target compounds were developed, and evaluation of biological activity at AMPA and NMDA receptors identified highly potent and in some cases very selective ligands.
Selective-area growth of GaN nanocolumns on titanium-mask-patterned silicon (111) substrates by RF-plasma-assisted molecular-beam epitaxy (2008)

The selective-area growth (SAG) of GaN nanocolumns by RF-plasma-assisted molecular-beam epitaxy is demonstrated by the use of Ti mask patterns on (111) Si substrates. At the growth temperature of 935°C, the GaN nanocolumns grew only on the stripe windows where Si was exposed, and the growth of nanocolumns on the Ti surface was completely suppressed. The SAG of GaN occurred above approximately 900°C, but below that no SAG occurred because GaN crystals nucleated on the Ti mask. When the window width was 120 nm, a single-nanocolumn was aligned along the Ti window.
Practical RSA-PAKE for Low-Power Device in Imbalanced Wireless Networks (2014)

For enhancing the security of ubiquitous communication, we have to consider three keywords: mobility, wireless, and low computing capability. In this paper, we study one of suitable security protocols for the ubiquitous communication environment. We discuss RSA-based password-authenticated key exchange (RSA-PAKE) protocols for imbalanced wireless networks where a party uses a low-power device to communicate with another party equipped with a powerful computing device. For imbalanced wireless network applications, it is important to reduce the cost of communication for a low-power device even though the cost for powerful devices is increasing. The most power-consuming operation in RSA-PAKE protocols is the reliability test of unauthorized RSA public keys. Hence, it is important to design an efficient reliability test method to construct an efficient RSA-PAKE protocol. In this paper, we propose a new reliability test technique and design a provably secure RSA-PAKE protocol using the technique. Our protocol is suitable for securing the communications conducted over imbalanced wireless networks since the operations computed by one communicating party are efficient enough to be implemented on most low-power devices such as mobile phones and PDAs. The cost of a low-power device is reduced by 84.25% compared with CEKEP, the most efficient RSA-PAKE protocol. We prove the security of our protocol under a firmly formalized security model.
INTERFACIAL ENZYMOLOGY OF GLYCEROLIPID HYDROLASES: Lessons from Secreted Phospholipases A2 (1995)

Interfacial enzymes operate at an organized interface such as lipid aggregates in contact with the aqueous phase. The enzyme phospholipase A2 is a well studied interfacial enzyme, and a discussion of its behavior at interfaces is the topic of this review. Knowledge gained from studies of phospholipases A2 can be applied toward the quantitative analysis of other interfacial enzymes. The kinetic analysis of these enzymes is greatly simplified if one establishes certain experimental conditions that limit the exchange of enzyme and substrate between different substrate aggregates. With such constraints, the kinetics can be analyzed in terms of classical Michaelis-Menten theory adopted for the action of enzymes at interfaces. It is also possible to describe other enzyme properties such as inhibition and substrate preferences in a meaningful way using formalism that is well known in solution-phase enzymology.
Dihydrofolate Reductase from the L1210R Murine Lymphoma. Fluorometric Measurements of the Interaction of the Enzyme with Coenzymes, Substrates, and Inhibitors* (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDihydrofolate Reductase from the L1210R Murine Lymphoma. Fluorometric Measurements of the Interaction of the Enzyme with Coenzymes, Substrates, and Inhibitors*J. P. Perkins and J. R. BertinoCite this: Biochemistry 1966, 5, 3, 1005–1012Publication Date (Print):March 1, 1966Publication History Published online1 May 2002Published inissue 1 March 1966https://pubs.acs.org/doi/10.1021/bi00867a028https://doi.org/10.1021/bi00867a028research-articleACS PublicationsRequest reuse permissionsArticle Views53Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Kinetic and Chemical Evidence for the Inability of Oxidized α1-Proteinase Inhibitor to Protect Lung Elastin from Elastolytic Degradation (1984)

The oxidation of human alpha 1-proteinase inhibitor results in the conversion of this protein into a form which cannot protect lung elastin from degradation by elastolytic proteinases. Data indicate that this is primarily because of the lowering of the association rate between the modified inhibitor and neutrophil elastase, as well as in a change in Ki from near 10(-14) to near 10(-10)M. This is consistent with the hypothesis that oxidation of alpha 1-proteinase inhibitor in the lung by cigarette smoke results in a lowering of the protection of this organ from elastolytic degradation.
Central Airway Obstruction Due to Tracheal Glomus Tumor (2018)

<b>Background</b> Tracheal glomus tumors are rare mesenchymal neoplasms that have the potential to cause malignant, central airway obstruction. They require a thoughtful approach to safely secure the airway and definitively resect the tumor. <b>Case Description</b> We report the clinical course of a 25-year-old man in severe respiratory distress secondary to tracheal glomus tumor and the subsequent surgical management. <b>Conclusion</b> Due to their hypervascular nature, greater familiarity with tracheal glomus tumors is needed to ensure appropriate preoperative planning and intervention.
Lysosome-mediated chemoresistance in acute myeloid leukemia (2022)

Despite the outstanding advances in understanding the biology underlying the pathophysiology of acute myeloid leukemia (AML) and the promising preclinical data published lastly, AML treatment still relies on a classic chemotherapy regimen largely unchanged for the past five decades. Recently, new drugs have been approved for AML, but the real clinical benefit is still under evaluation. Nevertheless, primary refractory and relapse AML continue to represent the main clinical challenge, as the majority of AML patients will succumb to the disease despite achieving a complete remission during the induction phase. As such, treatments for chemoresistant AML represent an unmet need in this disease. Although great efforts have been made to decipher the biological basis for leukemogenesis, the mechanism by which AML cells become resistant to chemotherapy is largely unknown. The identification of the signaling pathways involved in resistance may lead to new combinatory therapies or new therapeutic approaches suitable for this subset of patients. Several mechanisms of chemoresistance have been identified, including drug transporters, key secondary messengers, and metabolic regulators. However, no therapeutic approach targeting chemoresistance has succeeded in clinical trials, especially due to broad secondary effects in healthy cells. Recent research has highlighted the importance of lysosomes in this phenomenon. Lysosomes' key role in resistance to chemotherapy includes the potential to sequester drugs, central metabolic signaling role, and gene expression regulation. These results provide further evidence to support the development of new therapeutic approaches that target lysosomes in AML.
Selected statistical tables (2000)

The derivation of the t distribution was first published by W. S. Gosset in 1908. Gosset was employed by an Irish brewery that did not allow its employees to publish the results of their research. Gosset instead published his work using the pseudonym ‘Student.’ Consequently, the t distribution is often referred to as Student's t distribution.
High gain and broadband microstrip array antenna using combined structure of corporate and series feeding (2004)

The main purpose of this paper is to present a microstrip array antenna with high gain and broad band. A single patch with the gain over 9.5dBi and impedance bandwidth of about 19% at 12.2 GHz is designed. A microstrip array antenna using the designed single patch and combination of corporate and series feeding is also fabricated. The impedance bandwidth of a 2/spl times/12 array antenna is above 12.3 % for VSWR<2 and the gain is about 20.5 dBi.
Microtubule dynamics in the peripheral nervous system (2011)

The special architecture of neurons in the peripheral nervous system, with axons extending for long distances, represents a major challenge for the intracellular transport system. Two recent studies show that mutations in the small heat shock protein HSPB1, which cause an axonal type of Charcot-Marie-Tooth (CMT) neuropathy, affect microtubule dynamics and impede axonal transport. Intriguingly, while at presymptomatic age the neurons in the mutant HSPB1 mouse show a hyperstable microtubule network, at postsymptomatic age, the microtubule network completely lost its stability as reflected by a marked decrease in tubulin acetylation levels. We here propose a model explaining the role of microtubule stabilization and tubulin acetylation in the pathogenesis of HSPB1 mutations.
Kinetic Resolution of Epoxides with CO2 Catalyzed by a Chiral‐at‐Iridium Complex (2018)

Chiral-at-metal bis-cyclometalated iridium(III) complexes are introduced as a new class of chiral catalysts for the reaction of epoxides with CO<sub>2</sub> to form cyclic carbonates under conditions of kinetic resolution. Reactions are typically performed at room temperature in the presence of 1 mol % of iridium catalyst and 1.5 mol % of tetraethylammonium bromide as the nucleophilic cocatalyst to provide selectivity factors of up to 16.6. A variety of monosubstituted epoxides, including styrene epoxide, epoxides with aliphatic side chains, glycidyl ethers, and a glycidyl ester, are found to be suitable substrates. No polymerization side reaction is observed for any of the investigated substrates.
Nafion Ionomer-Based Single Component Electrolytes for Aqueous Zn/MnO2 Batteries with Long Cycle Life (2020)

Recently, aqueous rechargeable Zn/MnO2 batteries are emerging as promising energy storage aids owing to their improved safety, low cost of fabrication, and high energy density. However, the rapid decay of capacity during extended charge–discharge cycles hinders the prospect of this technology beyond lab-scale. In the conventional Zn/MnO2 cell, additives such as Mn2+ have been used to tackle the stability issue. Here, we demonstrate that cycling performance of the Zn/MnO2 cell can be improved substantially by using Nafion ionomer as the separator in combination with zinc-ion conducting electrolytes. The Nafion ionomer-based Zn/MnO2 cells do not require any Mn2+ additive in the electrolyte and hence termed as “single component” electrolytes. The postmortem study of the post-cycled electrodes reveals that the structural evolution of both the anode and cathode in various electrolytes (1 M Zn(CF3SO3)2, 1 M ZnSO4·7H2O, and 3 M ZnSO4·7H2O) during prolonged cycling significantly influences the cycle life of the respective cells. Optimizing the Nafion ionomer membrane with a suitable electrolyte could render the desired combination of high capacity and high cycle life for a Zn/MnO2 cell.
Temperature Tolerant On-Chip WDM Silicon Photonic Transmitter and AWGR-based Routing Interconnects (2022)

We demonstrate automated thermal drift compensation in a two-socket AWGR interconnect, incorporating a ring-modulator transmitter. Stable operation with an average Q=5.8 over a range of 9 ο C is achieved for 25 Gb/s on-chip modulated data.