gebhart/patrepeval huggingface dataset:
Positive modulator of bone morphogenic protein-2 (2023)

Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.
Static and Dynamic Analysis of Electrostatically Actuated MEMS Shallow Arches for Various Air-Gap Configurations (2021)

In this research, we investigate the structural behavior, including the snap-through and pull-in instabilities, of in-plane microelectromechanical COSINE-shaped and electrically actuated clamped-clamped micro-beams resonators. The work examines various electrostatic actuation patterns including uniform and non-uniform parallel-plates airgap arrangements, which offer options to actuate the arches in the opposite and same direction of their curvature. The nonlinear equation of motion of a shallow arch is discretized into a reduced-order model based on the Galerkin's expansion method, which is then numerically solved. Static responses are examined for various DC electrostatic loads starting from small values to large values near pull-in and snap-through instability ranges, if any. The eigenvalue problem of the micro-beam is solved revealing the variations of the first four natural frequencies as varying the DC load. Various simulations are carried out for several case studies of shallow arches of various geometrical parameters and airgap arrangements, which demonstrate rich and diverse static and dynamic behaviors. Results show few cases with multi-states and hysteresis behaviors where some with only the pull-in instability and others with both snap-through buckling and pull-in instabilities. It is found that the micro-arches behaviors are very sensitive to the electrode's configuration. The studied configurations reveal different possibilities to control the pull-in and snap-through instabilities, which can be used for improving arches static stroke range as actuators and for realizing wide-range tunable micro-resonators.
Verification of thermal stability of the field coil for the 70MW class superconducting generator (2000)

Superconducting generators have many advantages such as increasing generation efficiency, improving power system stability and reducing size and weight in comparison with conventional generators. 70 MW class superconducting generators are being developed in Japan to verify the basic technologies for a 200 MW class superconducting pilot generator. Manufacture of 70 MW slow response excitation type rotor has begun in 1992 and factory tests were conducted in 1996. Succeeding to the factory tests, the rotor was combined to the stator with air gap windings in the verification test facility in Osaka power station and verification tests were conducted in 1998. The advantages and the reliability of superconducting generators have been clarified in these tests. In this paper, experimental results and analysis of the stability of the superconducting field windings at two kinds of severe tests; a continuous pulse excitation test and a sudden short circuit test are discussed. The main results are summarized as follows. (1) Any quench has not occurred in the severe tests. (2) A calculation method for the temperature rise of the conductor and the helium is developed in order to explain the experimental results. The calculated results agree well with the experimental ones.
Molecular Dynamics approach to plasma-surface and plasma-reactivity processes (2017)

International audience
Upstrap for Estimating Power and Sample Size in Complex Models (2021)

Abstract Power and sample size calculation are major components of statistical analyses. The upstrap resampling method introduced by Crainiceanu and Crainiceanu (2018) was proposed as a general solution to this problem but has not been assessed in numerical experiments. We evaluate the power estimation properties of the upstrap for target data sets that are larger or smaller than the original observed data set. We also expand the scope of upstrap and propose a solution to estimate the power to detect: (1) an effect size observed in the original data; and (2) an effect size chosen by a researcher. Simulations include the following scenarios: one- and two-sample t-tests; linear regression with both Gaussian and binary outcomes; multilevel mixed effects models with both Gaussian and binary outcomes. In addition, our simulations consider cases where the distribution of a covariate in the target setting is preserved and when it is purposefully changed compared to the original data set. We illustrate the approach using a reanalysis of a cluster-randomized controlled trial of malaria transmission. The GitHub repository with R code used in manuscript analyses is available at https://git.io/J0TH1 . The accompanying data are publicly available.
Oxygen microelectrode measurements in R3230Ac Tumors during photodynamic therapy with verteporfin (2001)

Measurements of tissue oxygen partial pressure (pO2), blood flow and blood pressure were recorded in rat mammary R323OAc tumors during treatment with verteporfin-based photodynamic therapy. Microelectrodes of 12 micron tip diameter were used in a fixed position throughout the measurements to provide data on the temporal changes at a single location within the tissue. The microelectrode signal changes in P°2 indicated an overall trend to acute loss of P°2 after treatment, but with some notable exceptions where the P02 did not decrease either during the treatment or after treatment. These regions which showed little change in P02 were correlated with locations in which the P°2 was high to begin with before the initiation of treatment. Blood flow decreased during treatment, with the dominant effect immediately upon the initiation of treatment.
MonteBoxFinder: Detecting and Filtering Primitives to Fit a Noisy Point Cloud (2022)

We present MonteBoxFinder, a method that, given a noisy input point cloud, fits cuboids to the input scene. Our primary contribution is a discrete optimization algorithm that, from a dense set of initially detected cuboids, is able to efficiently filter good boxes from the noisy ones. Inspired by recent applications of MCTS to scene understanding problems, we develop a stochastic algorithm that is, by design, more efficient for our task. Indeed, the quality of a fit for a cuboid arrangement is invariant to the order in which the cuboids are added into the scene. We develop several search baselines for our problem and demonstrate, on the ScanNet dataset, that our approach is more efficient and precise. Finally, we strongly believe that our core algorithm is very general and that it could be extended to many other problems in 3D scene understanding.
Comparison of Two-Talker Attention Decoding from EEG with Nonlinear Neural Networks and Linear Methods (2019)

Auditory attention decoding (AAD) through a brain-computer interface has had a flowering of developments since it was first introduced by Mesgarani and Chang (2012) using electrocorticograph recordings. AAD has been pursued for its potential application to hearing-aid design in which an attention-guided algorithm selects, from multiple competing acoustic sources, which should be enhanced for the listener and which should be suppressed. Traditionally, researchers have separated the AAD problem into two stages: reconstruction of a representation of the attended audio from neural signals, followed by determining the similarity between the candidate audio streams and the reconstruction. Here, we compare the traditional two-stage approach with a novel neural-network architecture that subsumes the explicit similarity step. We compare this new architecture against linear and non-linear (neural-network) baselines using both wet and dry electroencephalogram (EEG) systems. Our results indicate that the new architecture outperforms the baseline linear stimulus-reconstruction method, improving decoding accuracy from 66% to 81% using wet EEG and from 59% to 87% for dry EEG. Also of note was the finding that the dry EEG system can deliver comparable or even better results than the wet, despite the latter having one third as many EEG channels as the former. The 11-subject, wet-electrode AAD dataset for two competing, co-located talkers, the 11-subject, dry-electrode AAD dataset, and our software are available for further validation, experimentation, and modification.
Control Methods in Data-Storage Systems (2011)

The recording performance of data-storage devices, in which write/read elements move relative to a storage medium to reliably store and retrieve information, depends on the capability of servo mechanisms to provide the necessary positioning accuracy. The desired characteristics of servo mechanisms for data-storage systems include robustness against variations of environmental parameters, high resolution, accuracy, stability, and fast response. This paper presents a comprehensive overview of advanced servo-control methods for data storage. The applications are to well-established recording technologies, including magnetic tape and magnetic disk systems as well as CD/DVD/Blue-Ray optical data-storage systems. Moreover, newer holographic and near-field optical systems and the emerging probe-storage technology are also addressed. Emphasis is given to the potential exhibited by the technologies considered for achieving ultra-high storage capacity, as required by the exploding demand in data-storage capacity for archival systems and massive multimedia data storage.
Bayesian Synchronous Tree-Substitution Grammar Induction and Its Application to Sentence Compression (2010)

(Article begins on next page) The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. Citation Yamangil, Elif and Stuart M. Shieber. 2010. Bayesian synchronous tree-substitution grammar induction and its
Amplitude spectrum estimation for two-dimensional gapped data (2002)

The amplitude and phase estimation (APES) approach to nonparametric spectrum estimation of uniformly sampled data has received considerable interest. We consider the extension of APES to gapped data, i.e., uniformly sampled data with missing samples. It has been shown that the APES estimate of the spectrum is the minimizer of a certain least-squares (LS) criterion, and our extension of APES is based on minimizing this LS criterion with respect to the missing data as well. A computationally efficient method for doing this based on cyclic minimization and the conjugate gradient algorithm is proposed. The new algorithm is called gapped-data APES (GAPES) and is developed for the two-dimensional (2-D) case, with the one-dimensional (1-D) case as a special instance. Numerical examples are provided to demonstrate the performance of the algorithm and to show the advantages of 2-D data processing over 1-D (row or column-wise) data processing, as well as to show the applicability of the algorithm to synthetic aperture radar (SAR) imaging.
Abstract 19094: Antihypertensive Properties of Subcutaneous M-ANP, a Novel Designer Atrial Natriuretic Peptide, in a Canine Model of Chronic Angiotensin-II Induced Hypertension (2014)

Introduction: Blood pressure (BP) control remains low despite combination therapy in resistant hypertension (RH). Thus, there is an unmet need for novel strategies targeting RH. Recently we have reported that M-ANP, a novel Mayo engineered ANP-based peptide, possesses greater and more sustained biological actions compared to ANP and is more resistant to neprilysin degradation. The current study was designed to investigate for the first time the efficacy of a single daily subcutaneous (SQ) injection of M-ANP using a chronic canine model of hypertension induced by angiotensin II (Ang-II). Hypothesis: We hypothesize that a daily SQ M-ANP injection would have potent BP lowering and renal enhancing properties in our chronic hypertensive canine model. Methods: We induced hypertension in canines (n=5) by continuous Ang II (80 ng/kg/min) osmotic mini-pump administration for 24 days. Continuous 24 hour mean BP (MBP) was measured by telemetry and a 24 hour urine collection was used to assess urinary volume, sodium (Na) and cGMP, the second messenger for the ANP system. M-ANP was administered SQ for 5 days (10μg/kg/day). Data are mean±SE. ΨP&lt;0.05 Ang II Day 16 vs. baseline; *P&lt;0.05 Ang II Day 16 vs. M-ANP (Table 1). Results: Chronic Ang II administration resulted in model of severe hypertension, with an increase in MBP from 112±2 to 157±2 mmHg (day 16). As seen in Table 1, M-ANP significantly reduced MBP, significantly increased plasma cGMP as well as urinary cGMP excretion, urinary volume rate (UV) and urinary Na excretion (UNa), without significant changes in heart rate (HR). Furthermore, there was a trend for plasma ANP to increase and plasma aldosterone to decrease with SQ M-ANP injection. Conclusions: This study demonstrates for the first time that chronic SQ administration of M-ANP reduces BP, activates plasma cGMP, and increases UV and UNa, without significant changes in HR in an experimental model of chronic hypertension.
Determination of the Dissociation Rate of Dodecylpyridinium Iodide Micelles by a Temperature-Jump Technique1a,b (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of the Dissociation Rate of Dodecylpyridinium Iodide Micelles by a Temperature-Jump Technique1a,bGordon C. Kresheck, Eugene Hamori, Gary Davenport, and Harold A. ScheragaCite this: J. Am. Chem. Soc. 1966, 88, 2, 246–253Publication Date (Print):January 1, 1966Publication History Published online1 May 2002Published inissue 1 January 1966https://pubs.acs.org/doi/10.1021/ja00954a013https://doi.org/10.1021/ja00954a013research-articleACS PublicationsRequest reuse permissionsArticle Views227Altmetric-Citations128LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
PROGESTTN AUGMENTATION OF GONADOTROPIN-STIMULATED PROGESTERONE PRODUCTION BY CULTURED RAT GRANULOSA CELLS (1983)

Ovarian progesterone production is stimulated by FSH and LH. Concomitant treatment with a synthetic progestin, R5020, (10(-6)M) increases the FSH-stimulated production of progesterone and 20 alpha-hydroxypregn-4-en-3-one (20 alpha-OH-P) in cultured rat granulosa cells. Likewise, R5020 augments the LH-stimulated progestin production in FSH-primed cells. Furthermore, the FSH stimulation of pregnenolone biosynthesis is enhanced by 10(-6) M of progesterone or R5020. These in vitro findings suggest that progestins may exert an autoregulatory positive feedback action to enhance gonadotropin-stimulated production of progesterone and 20 alpha-OH-P.
Photoelectrochemical performance of BiVO_4 photoanodes integrated with [NiFe]-layered double hydroxide water oxidation nanocatalysts (2018)

We integrated laser-made highly active nickel iron layered double hydroxide ([NiFe]-LDH) water oxidn. nanocatalysts, which we&#13;\ndeveloped in our group, with BiVO_4 photoanodes and tested their photoelectrochem. performance under simulated sunlight&#13;\nillumination. We demonstrated decreased aggregation and increased photocurrent generation with nanocatalysts that contain&#13;\ndipos. metals ([NiFe]-LDH and cobalt oxide) as citrate surfactant selectively ligated the catalyst nanoparticles. We also&#13;\noptimized catalyst mass loading, which is a tradeoff between most efficient depletion of photogenerated holes that drive&#13;\ncatalytic turnover and parasitic light absorption by the catalyst particles. Integrated [NiFe]-LDH-BiVO_4 photoanodes enhanced&#13;\nphotocurrent generation by a factor of 3.3 compared to bare BiVO_4. Comparison of photoelectrochem. performance of&#13;\nintegrated [NiFe]-LDH-BiVO_4 photoanodes in sulfite-free aq. electrolyte with photocurrent generation of neat BiVO_4&#13;\nphotoanodes in aq. electrolyte with sulfite added as sacrificial hole acceptor showed that two thirds of all photogenerated holes&#13;\nescaped loss processes in our optimized integrated photoanodes. Our systematic integration strategies provide a path towards&#13;\nfunctional artificial photosynthesis devices.
Predictors of pain medication use for arthroplasty pain after revision total knee arthroplasty (2014)

Younger age and depression were risk factors for the use of NSAIDs and narcotic pain medications for index TKA pain at 2- and 5-years after revision TKA.
Sodium metaarsenite (KML001) induces a G1 phase arrest in HCT116 colorectal cancer cells (2010)

Arsenic‐based reagents have been used as medicines, but they can cause chromosomal abnormalities in vitro and in vivo. Recent studies have reported alterations in telomere kinetics caused by the arsenic compound sodium metaarsenite (KML001), suggesting that it may be useful as an anti‐cancer reagent. Here, we investigated the anti‐cancer effects of KML001 on HCT116 cells. The expression of autophagic and apoptotic molecules were measured by RT‐PCR and immunoblotting in HCT116 cells and SW480 treated with KML001. KML001 reduced colorectal cancer cell proliferation in a concentration‐dependent manner, with a significant reduction at 1 μM ( p &lt;.05). p53 expression and conversion of LC3I to LC3II were dramatically increased, whereas no significant changes in caspase 3 and Bcl‐1 were observed ( p &lt;.05). Compared to the controls, the number of cells in G1 phase decreased 48 h after KML001 treatment, and the expression of several cyclin‐dependent kinase inhibitors was significantly increased ( p &lt;.05). In neonatal cardiomyocytes, morphologic signs of atrophy and a reduction in the number of differentiated cells were observed. Finally, a dramatic decrease in beating frequency and the number of embryoid bodies was noted after 18 h of treatment. KML001, which targets telomere kinetics, suppresses the proliferation of HCT116 cells, which might induced by a G1 phase arrest. Funding: BioGreen21 Program (Code No. 20070401‐034‐006‐009‐02‐00), Rural Development Administration, Korea
Dexamethasone Induces Lipocalin‐Type Prostaglandin D Synthase Gene Expression in Mouse Neuronal Cells (2000)

Lipocalin-type prostaglandin (PG) D synthase (L-PGDS) is responsible for the production of PGD(2), the main PG in the CNS. PGD(2) is an endogenous sleep inducer, and it is involved in the control of odor and pain responses and body temperature. In addition, PGD synthase transports lipophilic molecules in the subarachnoid space and CSF. By northern and western assays we show that the synthetic glucocorticoid dexamethasone, an inhibitor of PG production in most tissues, induces L-PGDS mRNA and protein in a dose- and time-dependent fashion in mouse neuronal GT1-7 cells. Accordingly, dexamethasone increases cellular L-PGDS enzymatic activity. Dexamethasone induced L-PGDS gene transcription in run-on assays and activated the mouse L-PGDS gene promoter in transiently transfected cells. It is interesting that the tumor promoter 12-O-tetradecanoyl-phorbol 13-acetate (TPA), which induces the synthesis of PGs in many tissues, inhibited the increase in L-PGDS expression induced by dexamethasone. In contrast, neither dexamethasone nor TPA affected the expression of cyclooxygenases-1 and -2. Our data demonstrate that dexamethasone induces L-PGDS gene transcription in neuronal cells.
Amelioration of Mucositis in Proton Therapy of Fanconi Anemia Fanca−/− Mice by JP4-039 (2019)

JP4-039 protected Fanca<sup>-/-</sup> and Fanca<sup>+/+</sup> cells and mouse oral cavity from both proton and photon radiation.
Nonlinear dynamics of flame in a narrow channel with a temperature gradient (2006)

The non-stationary behaviour of near-limit premixed flame propagating in a microchannel with temperature gradient was theoretically investigated. A one-dimensional (1D) nonlinear evolutionary equation of the flame front was obtained. The nonlinear model outlined the flame stabilization, nonlinear flame oscillations and flames with repetitive extinction and ignition processes that were observed in experiments.
256 Mb DRAM technologies for file applications (1993)

The authors describe 256-Mb DRAM (dynamic random access memory) technologies for file applications. A subthreshold-current limiting scheme for word drivers is shown. The scheme uses a pMOS switching transistor between the wordline voltage and the driver transistor common-source terminal. The subthreshold current of a 256-Mb DRAM is reduced to 3% by applying this scheme to word drivers and decoders, and the total data-retention current is less than that of a 64-Mb DRAM. A redundancy technique is shown which features subarray-by-subarray replacement instead of the conventional line-by-line replacement. To evaluate the circuit technologies described here, an experimental 256-Mb DRAM was fabricated using 0.25- mu m CMOS technology with phase-shift lithography. It uses a 0.72- mu m/sup 2/ RSTC cell with a storage capacitance of 25 fF and operates on a voltage of 1.5-3.6 V.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>