gebhart/patrepeval huggingface dataset:
Spectroelectrochemical Investigations of Cation-Insertion Reactions at Sol−Gel-Derived Nanostructured, Mesoporous Thin Films of Manganese Oxide (2001)

Sol−gel-derived manganese oxide can readily be prepared as highly porous, nanostructured materials, including ambigel or aerogel monoliths and thin films supported on conductive, transparent glass. The electrochromic properties of manganese oxide, a mixed electron−cation conductor, provide an independent measure of the electronic state of the manganese in the oxide during the electrochemically driven cation-insertion process. Sol−gel-derived thin films of birnessite-type manganese oxide, NaδMnO2·xH2O, which is a layered polymorph of MnO2, were characterized by spectroelectrochemistry. During nonaqueous electroinsertion reactions of Li+, Mg2+, and tetrabutylammonium cation, the spectral and electrochemical signatures are temporally distinguished and electrochemical site specificity can also be discerned. The rate of coloration of the oxide (recovery of the Mn(IV) state) is approximately 4-fold more rapid than the rate of decoloration as Mn(III) centers are electrogenerated and electrolyte-derived cations are concomitantly inserted. The electrochromic efficiency for Li+ insertion into thin films of birnessite-type manganese oxides is 36 cm2 C-1.
654 Personalised tumour-trained lymphocytes derived from regional lymph nodes for treatment of colorectal cancer (2022)

<h3>Background</h3> Adoptive T cell therapy as a treatment for solid tumours is gaining increasing interest. Cancer neoantigens as targets for such therapy is also gaining recognition. Personalised tumour trained lymphocytes (pTTL) is a novel autologous T cell therapy targeting patient-specific neoantigens. A phase I/II First in Human (FIH) clinical trial of pTTL in Stage IV colorectal cancer (CRC) patients will be initiated in the near future. Methods pTTL is produced through <i>in vitro</i> expansion of T cells derived from regional lymph nodes (RLNs). The T cells derived from RLNs, nodes in anatomical proximity of the tumour, contain a pool of naive and antigen-experienced T cells enriched for tumour-antigen specificity. This enriched population is stimulated during pTTL production with an array of neoantigen epitopes individually designed using PIOR®, an in house-developed software for neoantigen detection and selection. Selected neoantigens are linked to paramagnetic particles using EpiTCer® technology. The resulting EpiTCer® particles are used to stimulate the RLN T cells via phagocytosis and presentation of the neoantigen epitopes by antigen-presenting cells. This process is HLA-independent. Each pTTL product is unique due to the personalised nature of cellular and molecular players (cancer characteristics, immune cell properties and neoantigens are specific to one single individual). In the planned FIH trial patients with Stage IV CRC which have either no remaining relevant standard care therapies or which are in a scheduled break in such therapy can be included. pTTL will be administered as a single dose monotherapy after chemotherapy-based preconditioning with cyclophosphamide and fludarabine. The primary endpoint of the trial is safety of pTTL. Biomarker analysis of pTTL persistence and characteristics will also be central in trial assessments, and clinical outcome and response will be evaluated. <h3>Results</h3> Clinical results are not yet available. We here present central pTTL product characteristics. We have found that pTTL can be manufactured with a high rate of success despite the patient-specific nature of each product. The majority of the cells in pTTL are T cells, with small proportions of remaining NK and B cells originating from the RLN. The CD4 and CD8 T cell ratio are variable. Main pTTL characteristics include a significant proportion of memory T cells and phenotypic markers indicating maintained functionality such as limited levels of Temra (late stage memory cells re-expressing CD45RA) and CD57+ T cells, and maintained expression of CD28. TCRseq data have shown increased clonality in pTTL compared to RLNs, indicating antigen-specific expansion. <h3>Trial Registration</h3> EUDRA CT #2022-000394-96 <h3>Ethics Approval</h3> The trial have been approved by the Swedish Ethical Review Authority, Approval # 2022-01842-01 <h3>Consent</h3> Written informed consent will be requested from study participants in future, but no study subjects have yet been included.
Single-element and phased-array transceiver chipsets for 60-ghz Gb/s communications (2011)

This article summarizes the development of mature and highly integrated SiGe BiCMOS ICs for gigabit-per-second communications according to the requirements of the IEEE 802.15.3c and 802.11.ad-draft standards. A single-element transceiver chipset for point-to-point communications is described with emphasis on a feature-rich yet compact 60-GHz receiver. Next, a 16-element phased-array transceiver chipset for non-line-of-sight communications is described, with emphasis on a new power-efficient phased-array transmitter. Examples of gigabit-per-second line-of-sight and non-line-of-sight link experiments are provided, and system-level implementation trade-offs are discussed.
Photoemission and Low-Energy Electron-Diffraction Studies of α-Sn Growth on InSb Surfaces (2005)

TEST 02 - Elsevier's Scopus, the largest abstract and citation database of peer-reviewed literature. Search and access research from the science, technology, medicine, social sciences and arts and humanities fields.
An Increase in Helicobacter pylori Strains Resistant to Metronidazole: A Five‐Year Study (1996)

This study shows a rapid increase in metronidazole-resistant H. pylori with the use of an anti-Helicobacter regimen that contains metronidazole. We anticipate that the efficacy of metronidazole-containing anti-Helicobacter regimens will decline with the rapid rise in resistant strains of H. pylori.
Rapid quantification of two chemical nerve agent metabolites in serum (2019)

Organophosphorus compounds (OPs) continue to represent a significant chemical threat to humans due to exposures from their use as weapons, their potential storage hazards, and from their continued use agriculturally. Existing methods for detection include ELISA and mass spectrometry. The new approach presented here provides an innovative first step toward a portable OP quantification method that surmounts conventional limitations involving sensitivity, selectivity, complexity, and portability. DNA affinity probes, or aptamers, represent an emerging technology that, when combined with a mix-and-read, free-solution assay (FSA) and a compensated interferometer (CI) can provide a novel alternative to existing OP nerve agent (OPNA) quantification methods. Here it is shown that FSA can be used to rapidly screen prospective aptamers in the biological matrix of interest, allowing the identification of a 'best-in-class' probe. It is also shown that combining aptamers with FSA-CI enables quantification of the OPNA metabolites, Sarin (NATO designation "G-series, B", or GB) and Venomous Agent X (VX) acids, rapidly with high selectivity at detection limits of sub-10 pg/mL in 25% serum (by volume in PBS). These results suggest there is potential to directly impact diagnostic specificity and sensitivity of emergency response testing methods by both simplifying sample preparation procedures and making a benchtop reader available for OPNA metabolite quantification.
Production of Intracraniai aneurysms animal model (2009)

颅内动脉瘤是最常见的脑血管病之一,发病率仅次于脑血栓形成和高血压性脑出血.动脉瘤破裂每年发病率约10/10万人,而未破裂动脉瘤由于多数无症状,发病率难以准确计算,根据尸检及影像检查结果估算为0.2%～8.9% [2].因此,探讨颅内动脉瘤的组织病理学与病理生理学改变、动脉瘤的演变过程和破裂机制对预防颅内动脉瘤破裂和临床治疗具有极其重要的意义,而这些研究在一定程度上均依赖于建立稳定可靠的颅内动脉瘤模型。
Subclinical Brain Injury Caused by H5N1 Influenza Virus Infection (2011)

Although H5N1 influenza A viruses can cause systemic infection, their neurotropism and long-term effects on the central nervous system (CNS) are not fully understood. We assessed H5N1viral invasion of the CNS and its long-term effects in a ferret model. An H5N1 virus caused nonsuppurative encephalitis, which lasted for 3 months without neurologic signs. Further, another H5N1 virus caused nonsuppurative vasculitis with brain hemorrhage. Three-dimensional analysis of viral distribution in the brain identified the olfactory system as a major route for brain invasion. The efficient growth of virus in the upper respiratory tract may thus facilitate viral brain invasion.
"Elaboration de piles à combustible par procédés plasmas basse pression" (2006)

National audience
Surface and Bulk Defect Equilibria in Strontium-Doped Lanthanum Cobalt Iron Oxide (2009)

Strontium-doped lanthanum cobalt iron oxide is used in solid oxide fuel cells, oxygen separation membranes, and fuel reforming applications because of its mixed ionic and electronic conductivity. With changes in temperature and oxygen partial pressure , the defect concentration changes and there is a corresponding change in strain (chemical expansion) and performance. In this paper, the oxygen nonstoichiometry of 0.5% A-site cation deficient is studied in the temperature range of and modeled using a metallic model and three semiconductor models assuming itinerant electrons and holes or electrons localized on B-site, cations, with holes localized on either B-site cations or oxygen anions. The model consisting of holes localized on B-site cations fits the data best. The surface oxygen nonstoichiometry was determined by measuring oxygen loss of samples with different surface areas, and the surface is much more defective than the bulk. A long-term mass change measurement was also performed at in air, and a mass loss was observed that may be due to cation segregation to the surface.
ChemInform Abstract: Manganese(III) Acetate‐Induced Cyclization of α‐Arylalkyl and α‐(Aryloxy)alkyl β‐Dicarbonyl Derivatives. (1989)

Abstract The ring closure reaction mentioned in the title is performed upon heating diesters or related dicarbonyl compounds in the presence of manganese triacetate trihydrate, yielding indans, tetralins, or benzopyrans.
Scattering analysis accelerated by a 3-D multilevel non-uniform grid field evaluation algorithm (2007)

A fast algorithm for computing the scattering cross section of arbitrary shaped large rigid bodies using an iterative method of moments solver has been presented. The main computational bottleneck of such iterative solvers stems from the need to perform at each iteration at least one matrix-vector product. If performed directly, matrix-vector multiplication, which is equivalent to field evaluation for a given source distribution, is characterized by O(N2) complexity (N being the number of unknowns). To that end, a multilevel non-uniform grid (MLNG) algorithm for 3-D fast field evaluation has been proposed, developed, and tested on representative examples of elongated, quasi-planar, and full 3-D scatterers. The algorithm relies on hierarchical domain decomposition, field evaluation on highly sparse non-uniform grids, and multilevel field aggregation through phase-compensated interpolations. Computational complexity and memory requirements of O(N&amp;lt;th&amp;gt;log10&amp;lt;th&amp;gt;N) have been achieved by the MLNG without affecting the convergence of the iterative solver. Complexity of the MLNG is similar to that of the multilevel fast multipole algorithm [S. Ko and W. C. Chew, J. Acoust. Soc. Am. 103, 721–734 (1998)]. The MLNG approach is inherently geometrically adaptive, provides seamless transition from the high frequency to quasi-static regime, and is quite easy to implement.
CRC-Assisted Error Correction in a Convolutionally Coded System (2006)

In communication systems employing a serially concatenated cyclic redundancy check (CRC) code along with a convolutional code (CC), erroneous packets after CC decoding are usually discarded. The list Viterbi algorithm (LVA) and the iterative Viterbi algorithm (IVA) are two existing approaches capable of recovering erroneously decoded packets. We first propose an iterative log-MAP (ILM) algorithm improves error performance by iteratively updating the extrinsic information based on the CRC parity check matrix. We further derive a soft-decision syndrome decoding (SDSD) algorithm, which identifies error patterns from a set of binary linear equations derived from CRC syndrome equations. Being non-iterative, SDSD is able to estimate error patterns directly from the decoder output. The packet error rate (PER) performance of SDSD is analyzed following the union bound approach on pairwise errors. Simulations indicate that SDSD outperforms both ILM and LVA with weak CC and strong CRC. Applicable to AWGN and flat fading channels, our algorithms can also be extended to turbo coded systems.
The aligned rank transform for nonparametric factorial analyses using only anova procedures (2011)

Nonparametric data from multi-factor experiments arise often in human-computer interaction (HCI). Examples may include error counts, Likert responses, and preference tallies. But because multiple factors are involved, common nonparametric tests (e.g., Friedman) are inadequate, as they are unable to examine interaction effects. While some statistical techniques exist to handle such data, these techniques are not widely available and are complex. To address these concerns, we present the Aligned Rank Transform (ART) for nonparametric factorial data analysis in HCI. The ART relies on a preprocessing step that "aligns" data before applying averaged ranks, after which point common ANOVA procedures can be used, making the ART accessible to anyone familiar with the F-test. Unlike most articles on the ART, which only address two factors, we generalize the ART to N factors. We also provide ARTool and ARTweb, desktop and Web-based programs for aligning and ranking data. Our re-examination of some published HCI results exhibits advantages of the ART.
Resonant RF Cavity Based Beam Chopping for Precise Control over Electron Arrival Time Distribution (2019)

Modulation (i.e., pulsing) of electron beams has been used in electron microscopy, mostly in a pumpprobe configuration, for achieving time resolution well beyond the typical framerates of cameras and other detectors [e.g., 1,2]. Meanwhile, there has been lively debate on the possible role of dose rate beside total dose as a factor governing reversible as well as irreversible loss of contrast in sensitive samples under investigation in high-resolution (S)TEM By extension, also the arrival time distribution of electrons in the beam may have a similar influence, leading to possible new application of time-modulated beams in the study of dose sensitive specimens
Differential epigenetic regulation of Aiolos expression in human tumoral cell lines and primary cells (2008)

In order to investigate the epigenetic component of Aiolos regulation, we analyzed the methylation status of its 5' CpG island in relation to histone modifications. Inhibition of CpG methylation restores Aiolos expression, as well as euchromatin-associated markers, in U937 and 1106 mel cell lines. DNA methylation and low levels of euchromatin-associated signatures are observed in U937 and 1106 mel cell lines, while the opposite characterizes Daudi, Jurkat, T and B cells. CpG methylation is not necessary to repress transcription in monocytes and melanocytes where silencing mechanism involves heterochromatin-associated signature. We show that DNA methylation directs Aiolos silencing and chromatin status in tumor cell lines, while in primary cells is mainly regulated by histone modifications.
Noninvasive Imaging of Therapeutic Gene Expression Using a Bidirectional Transcriptional Amplification Strategy (2008)

Promoters that limit transgene expression to tumors play a vital role in cancer gene therapy. Although tumor specific, the human Survivin promoter (pSurv) elicits low levels of transcription. A bidirectional two-step transcriptional amplification (TSTA) system was designed to enhance expression of the therapeutic gene (TG) tumor necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL or TR) and the reporter gene firefly luciferase (FL) from pSurv. An adenoviral vector carrying the enhanced targeting apparatus (Ad-pSurv-TR-G8-FL) was tested for efficiency and specificity of gene expression in cells and in living animals. Compared to the one-step systems (Ad-pSurv-FL or Ad-pSurv-TR), the bidirectional TSTA system showed tenfold higher expression of both the therapeutic and the reporter gene and their expression correlated in cells (R(2) = 0.99) and in animals (R(2) = 0.67). Noninvasive quantitative monitoring of magnitude and time variation of TRAIL gene expression was feasible by bioluminescence imaging of the transcriptionally linked FL gene in xenograft tumors following intratumoral adenoviral injection. Moreover, the TSTA adenovirus maintained promoter specificity in nontarget tissues following tail vein administration. These studies demonstrate the potential of the bidirectional TSTA system to achieve high levels of gene expression from a weak promoter, while preserving specificity and the ability to image expression of the TG noninvasively.
A phase noise minimization of CMOS VCOs over wide tuning range and large PVT variations (2006)

An automatic amplitude control circuit to minimize the phase noise of a LC-VCO is proposed and implemented by a 0.18-/spl mu/m CMOS process. The phase noise lower than -90dBc/Hz at 100kHz offset is achieved over a wide tuning range (from 2.2GHz to 2.8GHz) under large process (/spl Delta/V/sub th/ = /spl plusmn/100mV), temperature (from /spl sim/35/spl deg/C to 85/spl deg/C), and power supply (from 1.8V to 3V) variations.
AB074. Link between interocular correlation sensitivity and stereoscopic vision (2018)

Background: Stereoscopic Vision uses the disparity between the two images received by the two eyes in order to create a tridimensional representation. With this study, we aimed at providing an estimate of binocular vision at a level prior to disparity processing. In particular, we wanted to assess the spatial properties of the visual system for detecting interocular correlations (IOC).
Supplemental Table 2 from Detection of Therapeutically Targetable Driver and Resistance Mutations in Lung Cancer Patients by Next-Generation Sequencing of Cell-Free Circulating Tumor DNA (2023)

&lt;p&gt;Tissue next-generation sequencing gene coverage. A: Illumina TruSeq panel (47 genes), and B: Penn Precision Panel (20 genes)&lt;/p&gt;
High temperature thermometric phosphors for use in a temperature sensor (2023)

A high temperature phosphor consists essentially of a material having the general formula LuPO.sub.4 :Dy.sub.(x),Eu.sub.(y), wherein: 0.1 wt %.ltoreq.x.ltoreq.20 wt % and 0.1 wt %.ltoreq.y.ltoreq.20 wt %. The high temperature phosphor is in contact with an article whose temperature is to be determined. The article having the phosphor in contact with it is placed in the environment for which the temperature of the article is to be determined. The phosphor is excited by a laser causing the phosphor to fluoresce. The emission from the phosphor is optically focused into a beam-splitting mirror which separates the emission into two separate emissions, the emission caused by the dysprosium dopant and the emission caused by the europium dopent. The separated emissions are optically filtered and the intensities of the emission are detected and measured. The ratio of the intensity of each emission is determined and the temperature of the article is calculated from the ratio of the intensities of the separate emissions.
Genome Sequence and Annotation of Acremonium chrysogenum , Producer of the β-Lactam Antibiotic Cephalosporin C (2014)

The filamentous fungus Acremonium chrysogenum is the industrial producer of the β-lactam antibiotic cephalosporin C. Here, we present the genome sequence of strain ATCC 11550, which contains genes for 8,901 proteins, 127 tRNAs, and 22 rRNAs. Genome annotation led to the prediction of 42 gene clusters for secondary metabolites.
2011 In-Water Testing of Aquatic Nuisance Species Dispersal Barriers IIA and IIB with Increased Voltage and Frequency Operating Parameters (2011)

Abstract : US Army Engineer District - Chicago operates an electric field-based aquatic nuisance species dispersal barrier system in the Chicago Sanitary and Ship Canal (CSSC), Romeoville, IL. The barriers were constructed to prevent the movement of invasive species, such as Asian big-head carp (Hypophthalmichthys nobilis) and silver carp (Hypophthalmichthys molitrix) between the Mississippi River and Great Lakes basins. The objective of this project was to perform a series of in-water tests on the barrier addressing field-strength mapping, sparking potential during barge fleeting and collision, voltage potentials between barges traversing the barriers, personnel in-water shock potential, stray-current corrosion potential, and optimal settings for the parasitic barrier system. Test results and analysis indicate there is no significant risk of personnel shock hazard in the fleeting area during barrier operations for any operating configuration. Also, while some operational scenarios were found to increase sparking risk if barges collide with each other or separate metal objects, analysis indicates that concerns about coal dust explosion hazard from sparking are not supported by the technical literature. A detailed set of data, analysis, conclusions, and recommendations is provided in the report text and four appendices.
Instant insight: The wonder of gold (2008)

Gold is a material that has fascinated humankind since it was first discovered. It is the most noble of metals; it does not tarnish on exposure to the atmosphere and retains its beautiful lustre.
A novel wide-band microwave absorber with a decreased thickness (2012)

This paper presents a new design of an absorbing screen based on a classical Salisbury concept. In the new design a resistive sheet from the classical Salisbury screen is replaced by a patterned layer. This allows one to decrease the overall screen thickness while simultaneously eliminating major disadvantages of classical solutions, such as their narrow frequency bandwidth. Thereby EMC properties of such screens are improved. Electromagnetic simulations with QuickWave-3D package are conducted and confirm the theoretical predictions of the paper.
The influence of charge transport layers on the EL stability of QDLEDs (Conference Presentation) (2022)

Colloidal quantum dot (QD)-based light emitting devices are poised to become the leading technology in next generation flat panel displays but their electroluminescent (EL) stability is still insufficient for commercial applications. We recently found that using a cascaded hole transport layer (HTL) structure can lead to significant EL stability enhancements, prolonging device EL lifetime by 25 times. Introducing modifications to the ZnO electron transport layer can lead to similar benefits. Investigations show that the stability enhancement in both cases is associated with a better management of charge and exciton distributions in the HTL. Results from these investigations will be discussed.
Diagnostic system to study sub-THz emission from open trap at strong beam-plasma interaction (2016)

This article describes the diagnostic complex for investigation of plasma electromagnetic emission during beam-plasma interaction. Multichannel polychromator is used for measurements of spectral power density in frequency band of 100 ÷ 500 GHz. Two-channel polarimeter is used for obtaining information about emission polarization. The new cryogenic detector will be used for measurements of electromagnetic radiation over 600 GHz. Calorimetric detectors can also be used to increase the number of possible spatial registration points. Because experiments data interpretation depend on local plasma parameters such as plasma density or temperature diagnostic, complex include system of registration of density based on CO2-interferometry and Nd-laser scattering. The information about plasma temperature is obtained from diamagnetic loops.