gebhart/patrepeval huggingface dataset:
Eco-Friendly Engineered Nanomaterials Coupled with Filtering Fine-Mesh Net as a Promising Tool to Remediate Contaminated Freshwater Sludges: An Ecotoxicity Investigation (2023)

The use of eco-friendly engineered nanomaterials represents a recent solution for an effective and safe treatment of contaminated dredging sludge. In this study, an eco-designed engineered material based on cross-linked nanocellulose (CNS) was applied for the first time to decontaminate a real matrix from heavy metals (namely Zn, Ni, Cu, and Fe) and other undesired elements (mainly Ba and As) in a lab-scale study, with the aim to design a safe solution for the remediation of contaminated matrices. Contaminated freshwater sludge was treated with CNS coupled with a filtering fine-mesh net, and the obtained waters were tested for acute and sublethal toxicity. In order to check the safety of the proposed treatment system, toxicity tests were conducted by exposing the bacterium <i>Aliivibrio fischeri</i> and the crustacean <i>Heterocypris incongruens</i>, while subtoxicity biomarkers such as lysosomal membrane stability, genetic, and chromosomal damage assessment were performed on the freshwater bivalve <i>Dreissena polymorpha</i>. Dredging sludge was found to be genotoxic, and such genotoxicity was mitigated by the combined use of CNS and a filtering fine-mesh net. Chemical analyses confirmed the results by highlighting the abetment of target contaminants, indicating the present model as a promising tool in freshwater sludge nanoremediation.
Regional and ethnic differences among patients with heart failure in Asia: the Asian sudden cardiac death in heart failure registry (2016)

NCT01633398.
T-bet controls CD4+CD25+Foxp-3+ T regulatory cells and Th17 cells in lung adenocarcinoma (41.59) (2009)

Abstract The range of identified effector CD4+ T cell lineages has been expanded to enclose the Th17 cells whose function in lung tumor has not been investigated yet. In this study, we report increased expression of the two newly identified transcription factors of the Th17 lineage, RORA and RORC2, in the lung of patients affected by lung adenocarcinoma. Targeting IL-17A in a murine model of lung adenocarcinoma, resulted in local expansion of CD4+ effector T cells producing IFNγ and reduction of CD4+CD25+FOXP3+ regulatory T cells. In support of a protective role of IFNγ in this model, T-bet (-/-) mice exhibited increased tumor load, decreased survival and increased residual CD4+CD25+FOXP3+ T regulatory cells after anti-IL-17A antibodies treatment as compared to wild type littermates. Thus, blockade of lung Th17 responses requires T-bet to reduce T-regulatory cells for limiting lung cancer.
A Safe Hierarchical Planning Framework for Complex Driving Scenarios based on Reinforcement Learning (2021)

Autonomous vehicles need to handle various traffic conditions and make safe and efficient decisions and maneuvers. However, on the one hand, a single optimization/sampling-based motion planner cannot efficiently generate safe trajectories in real time, particularly when there are many interactive vehicles near by. On the other hand, end-to-end learning methods cannot assure the safety of the outcomes. To address this challenge, we propose a hierarchical behavior planning framework with a set of low-level safe controllers and a high-level reinforcement learning algorithm (H-CtRL) as a coordinator for the low-level controllers. Safety is guaranteed by the low-level optimization/sampling-based controllers, while the high-level reinforcement learning algorithm makes H-CtRL an adaptive and efficient behavior planner. To train and test our proposed algorithm, we built a simulator that can reproduce traffic scenes using real-world datasets. The proposed HCtRL is proved to be effective in various realistic simulation scenarios, with satisfying performance in terms of both safety and efficiency.
Analysis of Quality Factor Enhancement in the Monolithic InGaN/GaN Nanorod Array (2019)

Whispering gallery mode (WGM) lasers and resonators are key building blocks for photonic integrated circuits. The quality factor and resonant wavelength are strong functions of the cavity size. Nanoscale WGM cavities suffer from a low-quality factor due to prominent scattering loss. However, the quality factor could be enhanced by forming an optically-coupled rod array or photonic molecules. Through simulations, we revealed how rod-to-rod optical coupling influenced the threshold pumping level and dominant mode selection, where the trend showed good agreement with the experimental observation. According to the simulation, the quality factor could be enhanced by up to eight times by forming a six-rod photonic molecule. The quality factor and effective mode were both superior to the single rods with the same wafer device footprint.
Fluorometric analysis of galactose in whole blood spotted on paper (1979)

新生児の血液を滲み込ませた濾紙中のガラクトースを2%過塩素酸で抽出してgalactoseを測定する方法について検討した.この方法は除蛋白操作が容易で,安定した結果が得られるので血中ガラクトースの定量方法として有用である.本法による新生児血中ガラクトースの平均値は0.14mg/dlであり,生後の日齢による変動は見られなかった.
Cross-modal Attention Congruence Regularization for Vision-Language Relation Alignment (2023)

Rohan Pandey, Rulin Shao, Paul Pu Liang, Ruslan Salakhutdinov, Louis-Philippe Morency. Proceedings of the 61st Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers). 2023.
Multi-Timescale Online Optimization of Network Function Virtualization for Service Chaining (2018)

Network Function Virtualization (NFV) can cost-efficiently provide network services by running different virtual network functions (VNFs) at different virtual machines (VMs) in a correct order. This can result in strong couplings between the decisions of the VMs on the placement and operations of VNFs. This paper presents a new fully decentralized online approach for optimal placement and operations of VNFs. Building on a new stochastic dual gradient method, our approach decouples the real-time decisions of VMs, asymptotically minimizes the time-average cost of NFV, and stabilizes the backlogs of network services with a cost-backlog tradeoff of [ε, 1/ε], for any ε > 0. Our approach can be relaxed into multiple timescales to have VNFs (re)placed at a larger timescale and hence alleviate service interruptions. While proved to preserve the asymptotic optimality, the larger timescale can slow down the optimal placement of VNFs. A learn-and-adapt strategy is further designed to speed the placement up with an improved tradeoff [ε, log <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> (ε)/ε]. Numerical results show that the proposed method is able to reduce the time-average cost of NFV by 23 percent and reduce the queue length (or delay) by 74 percent, as compared to existing benchmarks.
Isolating Petroleum Pitch Oligomers via Multistage Supercritical Extraction (2010)

Petroleum pitches are carbonaceous materials that serve as precursors for advanced carbon products. Because of their highly graphitic nature, such pitches are of particular interest for producing high thermal conductivity carbon fibers for thermal management applications, such as microelectronics packaging for hybrid and plug-in vehicles. Even though the properties of the final carbon products are impacted by the molecular composition of the starting pitch precursor, a fundamental understanding of this relationship has yet to be established. To this end, dense-gas extraction (DGE), a fractionation technique that allows for the production of pitches of controlled composition for both analytical and rheological characterization, was investigated. A continuous-flow apparatus, consisting of two countercurrent-flow packed columns, was designed and constructed for this study. Supercritical toluene, pentane, and methanol were all investigated as extractive solvents. An oligomeric petroleum pitch, M-50, was used as the feed pitch. The effect of column temperature gradient and pressure, solvent-to-pitch (S/P) ratio, solvent composition, and feed location was shown to play a significant role in pitch yield, oligomeric composition, mesophase content, and physical properties of the fractions obtained herein. In addition, co-solvent interactions between pitch molecules, the existence of reflux in the presence of a column temperature gradient, and the presence of thermal polymerization reactions were all demonstrated to have a significant effect on the purity of the fractions isolated. For example, in isolating dimer-rich pitches, an improvement in purity from 81 to 99 mol% was achieved by changing the extractive solvent from toluene (Tc = 319 °C) to pentane (Tc = 197 °C) - toluene mixtures, and operating the DGE column as a stripper/rectifier (vs. stripper only) at a positive temperature gradient (270 Top, 240 °C Bottom) and a S/P ratio greater than 15. Pitches of narrow molecular weight distribution were isolated from the oligomeric feed pitch (M-50) on a continuous basis and characterized by MALDI mass spectrometry. In particular, monomer- and dimer-rich pitches with purities greater than 96 mol%, and trimer-rich pitches of 60 mol% purity, were obtained at overall product yields of 50% for the monomer, 14% for the dimer, and 5% for the trimer, at pitch flow rates ranging from 5 to 50 g/h. The softening point of pure monomer was found to be 40 °C, of pure dimer 215 °C, and of a trimer-rich cut 285 °C. By combining DGE with our analytical characterization techniques, we have been able to obtain the first reliable estimate of the molecular composition of M-50 pitch: 50 wt% monomer, 27 wt% dimer, and 23 wt% trimer and heavier species.
Eryptosis in Peritoneal Dialysis-Related Peritonitis: The Potential Role of Inflammation in Mediating the Increase in Eryptosis in PD (2022)

Background: Peritonitis and exit site infections are the main complications of patients treated with peritoneal dialysis (PD). Erythrocytes (red blood cells—RBCs) are very sensitive cells, and they are characterized by eryptosis (programmed cell death). The purpose of this research was to assess eryptosis in PD patients with PD-related peritonitis and its connection to inflammatory markers in vivo and in vitro. Material and Methods: In this study, we included 65 PD patients: 34 PD patients without systemic inflammation nor PD-related peritonitis in the previous 3 months, and 31 PD patients with an acute episode of PD-related peritonitis. We measured C-reactive protein (CRP) and cytokine (IL-1β, IL-6, and IL-18) levels as systemic inflammatory markers. Eryptosis was evaluated by flow cytometric analyses in freshly isolated RBCs. The induction of eryptosis due to in vitro exposure to IL-1β, IL-6, and IL-18 was verified. Results: Eryptosis was significantly higher in PD patients with peritonitis (9.6%; IQR 4.2−16.7), compared to the those in the other group (2.7%; IQR 1.6−3.9) (p < 0.0001). Significant positive correlations were noticed between eryptosis and CRP, IL-1β, and IL-6. RBCs, incubated with greater concentrations of all cytokines in vitro, resulted in significantly higher occurrences of eryptosis in comparison with those incubated with lower concentration and with untreated cell (p < 0.05), and for those with extensive exposure (p < 0.05). Conclusion: In conclusion, we investigated a potential relationship between systemic eryptosis and the in vivo and in vitro inflammatory damage of the peritoneal membrane during peritonitis. Thus, the presented results revealed that upregulated inflammatory markers and immune system dysregulation could be the cause of high levels of systemic eryptosis during PD-related peritonitis.
On the L p Brunn-Minkowski theory and the L p Minkowski problem for C-coconvex sets (2021)

Abstract Let $C$ be a pointed closed convex cone in ${{\mathbb {R}}^n}$ with vertex at the origin $o$ and having nonempty interior. The set $A\subset C$ is $C$-coconvex if the volume of $A$ is finite and $A^{\bullet }=C\setminus A$ is a closed convex set. For $0&amp;lt;p&amp;lt;1$, the $p$-co-sum of $C$-coconvex sets is introduced and the corresponding $L_p$ Brunn–Minkowski inequality for $C$-coconvex sets is established. We also define the $L_p$ surface area measures, for $0\neq p\in {\mathbb {R}}$, of certain $C$-coconvex sets, which are critical in deriving a variational formula of the volume of the Wulff shape associated with a family of functions obtained from the $p$-co-sum. This motivates the $L_p$ Minkowski problem aiming to characterize the $L_p$ surface area measures of $C$-coconvex sets. The existence of solutions to the $L_p$ Minkowski problem for all $0\neq p\in {\mathbb {R}}$ is established. The $L_p$ Minkowski inequality for $0&amp;lt;p&amp;lt;1$ is proved and is used to obtain the uniqueness of the solutions to the $L_p$ Minkowski problem for $0&amp;lt;p&amp;lt;1$. For $p=0$, we introduce $(1-\tau )\diamond A_1\oplus _0\tau \diamond A_2$, the log-co-sum of two $C$-coconvex sets $A_{1}$ and $A_{2}$ with respect to $\tau \in (0, 1)$, and prove the log-Brunn–Minkowski inequality of $C$-coconvex sets. The log-Minkowski inequality is also obtained and is applied to prove the uniqueness of the solutions to the log-Minkowski problem that characterizes the cone-volume measures of $C$-coconvex sets. Our result solves an open problem raised by Schneider [41].
A Brief Followup at 1 Year (2011)

Background Using comprehensive gait analysis and strength testing, we previously investigated the early (2-month) functional outcome after THA using twoincision and mini-posterior surgical approaches and found an advantage for the mini-posterior approach. Benefits included improved muscle strength, a less antalgic gait, and better hip function as reflected by changes in hip moments during level walking and stair climbing. We questioned how these differences in function would fare with longer followup.
Self-assembled squalenoyl-cytarabine nanostructures as a potent nanomedicine for treatment of leukemic diseases (2012)

Squalenoylation of cytarabine offers several pharmacological benefits both in vitro and in vivo.
Relative mRNA expression of pancreas development transcription factors by CD133+ cells isolated after 4 days of exocrine tissue culture. (2015)

&lt;p&gt;Mean ± SEM relative expression level of genes in CD133+ cells compared to the CD133-depleted (CD133D) population shown on Y-axis as fold difference. Significance determined by Student’s t-test from 2&lt;sup&gt;-Δct&lt;/sup&gt; values. ***, p&lt;0.001, **, p&lt;0.01, *, p&lt;0.05 (n = 4 exocrine cultures). Genes ranked in order of overexpression in the CD133+ population. Inset shows gene expression using an enlarged scale. Genes are: Neurogenin 3 (NGN3), One cut homeobox 2 (ONECUT2), NK6 homeobox 1 (NKX6.1), GLIS family zinc finger 3 (GLIS3), motor neuron and pancreas homeobox 1 (MNX1), HNF1 homeobox B (HNF1B), pancreatic and duodenal homeobox 1 (PDX1), SRY (sex determining region Y)-box 9 (SOX9), Hairy enhancer of split 1 (HES1), One cut homeobox 1 (ONECUT1), Forkhead box A2 (FOXA2), Forkhead box O1 (FOXO1), v-maf avian musculoaponeurotic fibrosarcoma oncogene family, protein B (MAFB), GATA binding protein 4 (GATA4), Pancreas specific transcription factor 1A (PTF1A), Neuronal differentiation 1 (NEUROD1), ISL LIM homeobox 1 (ISL1), paired box 6 (PAX6). No expression of NK2 homeobox 2 or paired box 4 was detected.&lt;/p&gt;
A Chemical IoT System for Flow Assurance - From Single-Well Applications to Field Implementation (2020)

Abstract Asphaltene deposition is a significant flow assurance challenge in Abu Dhabi with over 100 onshore wells impacted. Until recently, there had been no applicable IoT device in the industry for direct measurement of the problem, which prompted the national oil company to sponsor a real-time sensor for asphaltene quantification. A second generation of that device is now available with enhanced capabilities and has been delivered in country, with preparation now ongoing for deployment across multiple onshore wells. Current ways of identifying asphaltene problems via accessibility checks with slickline are reactive, often too late, and thereby increase cost of clean-up and production losses. By quantifying in real-time the asphaltene as it flows through the wellhead, much earlier problem detection is made feasible. Such quantification has been made possible by resonating asphaltene molecules in applied magnetic and GHz fields as those molecules flow through the wellhead. The peak of the resonant signal is directly proportional to the asphaltene in the crude, with decrease in signal indicating potential deposition. Adding cloud-based, machine-learning to the system allows local in-country team to make efficient use of the data. First deployment of the resonant system in Abu Dhabi demonstrated the resolution of asphaltene signature was better than 0.1% when measured at atmospheric pressure and temperature. Subsequent testing in pressure vessels has shown remarkable independence to fluid pressure, even up to 2000 psi. Original system had a sensitivity sufficient to detect only the asphaltene peak. New system reveals multiple smaller peaks in the spectra which can be used for other flow assurance applications - for example, vanadyl porphyrins display a unique characteristic. By mixing solvents and precipitants with crude oil, we have confirmed that the asphaltene peak measures same value whether the asphaltene is in, or out, of solution which is precisely the feature that allows surface data to be representative of the cumulative precipitation downhole. The main advance, however, is that the system data will now be available on multiple wells in the field, which allows Operator to compare and contrast different flow assurance optimizations. This should lead to substantial cost savings in addition to minimizing well downtime and potential loss of production, all in alignment with the Operator’s 2030 "Smart Growth" strategy. The additional spectral information also allows spectrometer use for real-time analysis of water properties (dissolved solids) and rock typing (geochemistry). More generally, the system becomes a real-time platform for advanced chemical analysis at the wellhead. The result is an industrial Internet of Things (IoT) real-time monitoring device, the first of its kind, that not just detects asphaltene deposition but also makes possible the optimization of chemical programs by incorporating surface data into an integrated flow assurance management system.
Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritis (2006)

Activated macrophages express a cell surface receptor for the vitamin folic acid. Because this receptor is inaccessible or not measurably expressed on other normal cells, folic acid has been recently exploited to selectively deliver attached radio-emitters to sites of activated macrophage accumulation, allowing scintigraphic imaging of inflamed joints and organs of arthritic rats. We demonstrate here that folate-linked haptens can also be targeted to activated macrophages, decorating their cell surfaces with highly immunogenic molecules. Under conditions in which the rodent has already been immunized against keyhole limpet hemocyanine-(fluorescein isothiocyanate) FITC, activated macrophages are eliminated. Administration of folate-FITC conjugates to rodents with experimental arthritis attenuates (a) systemic and peri-articular inflammation, (b) bone and cartilage degradation, and (c) arthritis-related body weight loss. Treatment with folate-hapten conjugates is comparable to methotrexate, etanercept, anakinra, and celecoxib at alleviating the symptoms of arthritis. We conclude that reduction of activated macrophages by folate-targeted immunotherapy can ameliorate the symptoms of arthritis in two rodent models of the disease.
Techno-Economic Analysis of Municipal Solid Waste Gasification to Methanol (2022)

This poster was presented at the tcbiomass Conference in April 2022 and discusses the techno-economic analysis of municipal solid waste gasification to methanol.
Radio Environment Monitoring (2021)

The high number of wireless devices available and the inherent relationship between electromagnetic wave propagation and the physical environment have made these devices and their network architectures ideal sources of information for noncommunication-related applications, such as home monitoring and heart beat detection. The number and significance of wireless sensing use-cases highlight the importance of a framework to acquire information on the radio environment. This chapter introduces such a framework, goes over relevant technologies, and provides a case study for environment sensing. The most well-studied area of radio environment map (REM) is perhaps the radio frequency map construction. The chapter provides this as an example for the working of the REM architecture. The generalized radio environment monitoring framework enables information gathering and radio and physical environment awareness, behaving as an independent entity capable of feeding information to other entities.
Characterization of 45 nm att-PSM lithography with a hyper-NA ArF tool (2005)

In the 45 nm half pitch node, a mask induced polarization effect is appeared. Also, this effect depends on optical diffraction orders. This is notable in an attenuated phase shift mask (att-PSM) rather than in a Cr binary mask (BIM). Diffraction efficiency is also different between dense patterns and larger pitch patterns. In lithography simulation, we have to use a rigorous method and to consider mask topology. With the rigorous method, focus tilt effect depending on mask pitch has been reported (Erdmann, 2005). Also, it has been reported that transmittance of att-PSM should be changed for 45 nm half pitch pattern (Sato et al., 2005). In this report, the authors investigate detailed characterization of the 45 nm att-PSM lithography with lithography simulation. In addition, we discuss impact of the focus tilt for ED-window and other characterization of the 45 nm att-PSM.
Noninvasive assessment of dofetilide plasma concentration using a deep learning (neural network) analysis of the surface electrocardiogram: A proof of concept study (2018)

This proof of concept study suggests that artificial intelligence (deep learning/neural network) applied to the surface ECG is superior to analysis of the QT interval alone in predicting plasma dofetilide concentration.
Desorption Studies of Hydrogen in Metal–Organic Frameworks (2008)

The diameter is decisive: Adsorption sites for hydrogen in the metal–organic frameworks Cu-BTC, MIL-53, MOF-5, and IRMOF-8 could be identified by using thermal desorption spectroscopy at very low temperatures (see graph). The correlation between the desorption spectra and the pore structure of these MOFs shows that at high hydrogen concentrations the diameter of the cavity determines the heat of adsorption. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z704053_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.