gebhart/patrepeval huggingface dataset:
Unified structure and parameter identification of fuzzy models (1993)

The unified approach to fuzzy modeling developed in this correspondence addresses the problems of structure and parameter identification of fuzzy models. It demonstrates an alternative view to structure identification, transforming the problem of structure identification to estimation of the distribution of input space. A new concept of sample probability distributions (SPD) is introduced and a family of SPD is constructed. This allows us to simplify the problem of structure identification by replacing identification of membership functions of input variables with identification of the centers of cluster-like regions. The fuzzy model complex of fuzzy model is also discussed in connection with the modeller's confidence and two types of confidence-a priori and a posteriori confidence-are also suggested. The identification problem is solved also under the additional requirement of simplification of the model structure. A learning algorithm realizing structure and parameter identification of quasilinear fuzzy models with the simplest structure is proposed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Costruzione e decostruzione (2019)

come si costruiscono e deostruiscono le immagini dello zingaro nei percorsi d'inclusione scolastica a partire del processo della conoscenza della storia
Demonstration of 3-band spatial frequency domain imaging using an 8-tap CMOS image sensor resistant to subject motion and ambient light (2022)

We demonstrate three-wavelength spatial frequency domain imaging (SFDI) of a moving arm under a room light with suppressing motion artifact and biased reflectance based on an 8-tap CMOS image sensor developed in our research group. The images for two projected patters for three wavelengths and that for only ambient light are captured. Three LEDs with the wavelengths of 660nm, 780nm, and 850nm were utilized to decompose the oxy-/ deoxyhemoglobin and melanin concentrations. The exposure time for each frame was 70ms. The total hemoglobin, tissue oxygen saturation, and scattering coefficient maps were obtained without any significant motion artifact.
Associations Between IQ, Total and Regional Brain Volumes, and Demography in a Large Normative Sample of Healthy Children and Adolescents (2010)

In the course of efforts to establish quantitative norms for healthy brain development by magnetic resonance imaging (MRI) (Brain Development Cooperative Group, 2006), previously unreported associations of parental education and temporal and frontal lobe volumes with full scale IQ and its verbal and performance subscales were discovered. Our findings were derived from the largest, most representative MRI sample to date of healthy children and adolescents, ages 4 years 10 months to 18 years 4 months. We first find that parental education has a strong association with IQ in children that is not mediated by total or regional brain volumes. Second, we find that our observed correlations between temporal gray matter, temporal white matter and frontal white matter volumes with full scale IQ, between 0.14 to 0.27 in children and adolescents, are due in large part to their correlations with performance IQ and not verbal IQ. The volumes of other lobar gray and white matter, subcortical gray matter (thalamus, caudate nucleus, putamen, and globus pallidus), cerebellum, and brainstem do not contribute significantly to IQ variation. Third, we find that head circumference is an insufficient index of cerebral volume in typically developing older children and adolescents. The relations between total and regional brain volumes and IQ can best be discerned when additional variables known to be associated with IQ, especially parental education and other demographic measures, are considered concurrently.
Effects of medical food leucine content in the management of methylmalonic and propionic acidemias (2017)

Investigations into the optimal composition of medical foods for MMA and propionic acidemia, and potential scenarios in which Leu supplementation may be beneficial are needed. Until then, MMA/propionic acidemia medical foods should be used judiciously in the dietary management of these patients and avoided altogether in cblC deficiency.
Turning theory to practice in model-based FDI: Successful application to new generation Airbus aircraft (2017)

This paper presents a parametric model-based monitoring technique for detection and confirmation of faults in control surface servo-loops related to the Electrical Flight Control System. It is shown that there exists a direction in the parameter space which is sensitive to the occurrence of the faults on interest. On-line system parameter estimation is combined with an appropriate parametric test decision for robust detection and confirmation of faults. The paper reports on a number of identified practical design considerations that should go along with the basic design in order to provide a viable technological solution. The method presented in this paper has reached level 5 on Technological Readiness Level scale under Validation & Verification investigations at Airbus, and is considered to be a credible unconventional option to support (not rule out) conventional industrial practices.
A Method for Enabling Context-Awareness at Transport Layer for Improved Quality-of-Service Control (2021)

As the 5G systems have introduced network slicing on the virtualized network environment, application-specific QoS (Quality of Service) management has come to the fore to support a range of services, such as eMBB (enhanced Mobile Broadband), URLLC (Ultra-Reliable Low Latency Communications), and mIoT (massive Internet of Things). It is expected for the next-generation systems to support more diverse applications demanding newer and granular quality characteristics for network services. Most of the current transport layer protocols, built on layering design and best-effort paradigm, do not provide the necessary precision and adaptability required for various QoS support. Therefore, we need new protocols that comprehend application behaviours and adapt to dynamic network conditions for more fine-grained QoS enhancement. This paper presents a Context-oriented Transport (CoT) layer for the next-generation network that understands the application context and adapts to varying network conditions with flow-based QoS control. CoT is an end-to-end software solution that improves the underlying network capacity utilization and prioritizes the traffic flows according to quality needs. We prototyped CoT in Linux/Android devices and evaluated the performance with emulated traffic environment. The experiments show that CoT reduces latency by up to 16.5% and improves average throughput by up to 30%, compared with Android 10 in LTE network, resulting from enhanced traffic classification and network utilization.
Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5–MYC Protein–Protein Interaction (2019)

The treatment of tumors driven by overexpression or amplification of MYC oncogenes remains a significant challenge in drug discovery. Here, we present a new strategy toward the inhibition of MYC via the disruption of the protein-protein interaction between MYC and its chromatin cofactor WD Repeat-Containing Protein 5. Blocking the association of these proteins is hypothesized to disrupt the localization of MYC to chromatin, thus disrupting the ability of MYC to sustain tumorigenesis. Utilizing a high-throughput screening campaign and subsequent structure-guided design, we identify small-molecule inhibitors of this interaction with potent in vitro binding affinity and report structurally related negative controls that can be used to study the effect of this disruption. Our work suggests that disruption of this protein-protein interaction may provide a path toward an effective approach for the treatment of multiple tumors and anticipate that the molecules disclosed can be used as starting points for future efforts toward compounds with improved drug-like properties.
Multiconverter System Design for Fuel Cell Buffering and Diagnostics Under UAV Load Profiles (2013)

This paper presents a multisource, multiconverter power system for electrically propelled unmanned aerial vehicles (UAVs) with a focus on promoting fuel cell health. Linearized multiconverter system analysis and the two extra element theorem (2EET) inform a system design for fuel cell current buffering and integral diagnostics. Integral diagnostics is in situ impedance spectroscopy achieved by controlling the power system to superpose a frequency-swept excitation current at the fuel cell terminals. An experimental system demonstrates hybridization of a solid-oxide fuel cell (SOFC) with a lead-acid battery having suitable current buffering and integral diagnostics performance under UAV load profiles. Experimental behavior is demonstrated with an electrically emulated SOFC stack or “reference simulator.” Impedance spectroscopy data measured during run-time clearly indicate both degradation and recovery phenomena in the SOFC.
KINEMATICS OF THE KNEE AFTER ACL RECONSTRUCTION (2002)

Objective: This study challenges the assumption that pivot shift is abolished once anterior stability is restored in the ACL reconstructed knee. Method: The kinematics of 7 cadaver knees were studied with the Flock-of-Birds, as pivot shift was repeated in intact, ACL deficient, then ACL reconstructed specimens with grafts tensioned at 0, 10, 20, 40 and 60N. All were BPTB grafts in similar positions. Results: Pivot shift is described as a sudden reduction from internal rotation of 8.57 +/− 2.3° at knee flexion of 24.2 +/− 11°; achieved with iliotibial loading of 56.2 +/− 11.5N, 2.26 +/− 0.6Nm valgus load and 1.5 +/− 0.4Nm internal torque. Internal rotation was significantly reduced at 40N (3.2°, p
Height and Mental Health and Health Utility Among Ethnic Chinese in a Polyclinic Sample in Singapore (2013)

Adult height has a positive association with mental health as measured by the SF-6D among ethnic Chinese in Singapore. Socioeconomic status and known physical health problems do not explain this association. Adult height had no association with SF-6D utility index scores.
Self-trapping threshold in disordered nonlinear photonic lattices (2013)

We investigate numerically and experimentally the influence of coupling disorder on the self-trapping dynamics in nonlinear one-dimensional optical waveguide arrays. The existence of a lower and upper bound of the effective average propagation constant allows for a generalized definition of the threshold power for the onset of soliton localization. When compared to perfectly ordered systems, this threshold is found to decrease in the presence of coupling disorder.
TIME REQUIRED FOR A SPECIFIED LEVEL OF ACCURACY IN NOISE CORRELATION MEASUREMENTS (2004)

Correlation measurement is an effective way of measuring noise components with a magnitude smaller than the system noise. The accuracy of such measurement depends on the system bandwidth, the magnitude of the noise to be measured compared to the system noise and the measurement time. The accuracy can be improved by increasing the measurement time. A method of estimating the measurement time required for a desired level of accuracy for a given system noise and bandwidth is presented.
Sulfate depletion triggers overproduction of phospholipids and the release of outer membrane vesicles by Neisseria meningitidis (2019)

Outer membrane vesicles (OMVs) produced by bacteria are interesting vaccine candidates. OMVs are nanoparticles that contain many immunogenic components, are self-adjuvating, and non-replicative. Despite recent insights in the biogenesis of OMVs, there is no consensus on a conserved mechanism of OMV release and the OMV yield from bacterial cultures remains low. For Neisseria meningitidis, a Gram-negative human pathogen causing meningitis and sepsis, a feasible OMV production method based on triggering OMV release by cysteine depletion has been described. In this study, we investigated the mechanism behind this external trigger for OMV release to improve the production process. Since enhanced OMV release upon cysteine depletion was associated with oxidative stress and redox responses, we investigate the influence of more oxidized sulfur sources on OMV release. We show that N. meningitidis grows similarly on sulfate, the most oxidized sulfur source, and OMV release is triggered by sulfur depletion in general. Sulfate depletion induced increased release of OMVs over cysteine depletion. Proteomics showed that sulfur depletion resulted in oxidative stress responses and upregulated phospholipid and LPS biosynthesis. Furthermore, OMVs produced by sulfur depletion were enriched in phospholipids. Mechanistically, we hypothesize that sulfur depletion results in overproduction of phospholipids causing increased bulging of the outer membrane and subsequent OMV release.
PEGylation of a Vesicular Stomatitis Virus G Pseudotyped Lentivirus Vector Prevents Inactivation in Serum (2003)

One disadvantage of vesicular stomatitis virus G (VSV-G) pseudotyped lentivirus vectors for clinical application is inactivation of the vector by human serum complement. To prevent this, monomethoxypoly(ethylene) glycol was conjugated to a VSV-G-human immunodeficiency virus vector expressing Escherichia coli beta-galactosidase. The modification did not affect transduction efficiency in vitro and protected the vector from inactivation in complement-active human and mouse sera. Blood from mice dosed intravenously with either the unmodified or the PEGylated virus particles was assayed for active vector by a limiting-dilution assay to evaluate transduction efficiency and for p24, an indicator of the total number of virus particles present. PEGylation extended the circulation half-life of active vector by a factor of 5 and reduced the rate of vector inactivation in the serum by a factor of 1,000. Pharmacokinetic profiles for the total number of virus particles present in the circulation were unaffected by PEGylation. Modification of the vector with poly(ethylene) glycol significantly enhanced transduction efficiency in the bone marrow and in the spleen 14 days after systemic administration of the virus. These results, in concert with the pharmacokinetic profiles, indicate that PEGylation does protect the virus from inactivation in the serum and, as a result, improves the transduction efficiency of VSV-G pseudotyped lentivirus vectors in susceptible organs in vivo.
Modeling and Analysis of Hybrid Fuel Cell Systems for Vehicular Applications (2006)

Modelling and analysis of a hybrid system of fuel cell, battery, and ultra capacitor for vehicle propulsion is presented in this paper. All the components are modelled individually using practical results. A new control strategy is designed to obtain the high performance and better energy efficiency. A new model for PEM fuel cell is used to size the fuel cell, ultracapacitor and battery and study their performances. Simulation of the system is performed using MATLAB/SIMULINK and the results are presented
Identification of Homogentisate Dioxygenase as a Target for Vitamin E Biofortification in Oilseeds (2016)

Soybean (Glycine max) is a major plant source of protein and oil and produces important secondary metabolites beneficial for human health. As a tool for gene function discovery and improvement of this important crop, a mutant population was generated using fast neutron irradiation. Visual screening of mutagenized seeds identified a mutant line, designated MO12, which produced brown seeds as opposed to the yellow seeds produced by the unmodified Williams 82 parental cultivar. Using forward genetic methods combined with comparative genome hybridization analysis, we were able to establish that deletion of the GmHGO1 gene is the genetic basis of the brown seeded phenotype exhibited by the MO12 mutant line. GmHGO1 encodes a homogentisate dioxygenase (HGO), which catalyzes the committed enzymatic step in homogentisate catabolism. This report describes to our knowledge the first functional characterization of a plant HGO gene, defects of which are linked to the human genetic disease alkaptonuria. We show that reduced homogentisate catabolism in a soybean HGO mutant is an effective strategy for enhancing the production of lipid-soluble antioxidants such as vitamin E, as well as tolerance to herbicides that target pathways associated with homogentisate metabolism. Furthermore, this work demonstrates the utility of fast neutron mutagenesis in identifying novel genes that contribute to soybean agronomic traits.
Cell cycle arrest in Era GTPase mutants: a potential growth rate‐regulated checkpoint in Escherichia coli (1998)

Era is a low-molecular-weight GTPase essential for Escherichia coli viability. The gene encoding Era is found in the rnc operon, and the synthesis of both RNase III and Era increases with growth rate. Mutants that are partially defective in Era GTPase activity or that are reduced in the synthesis of wild-type Era become arrested in the cell cycle at the predivisional two-cell stage. The partially defective Era GTPase mutation (era1) suppresses several temperature-sensitive lethal alleles that affect chromosome replication and chromosome partitioning but not cell division. Our results suggest that Era plays an important role in cell cycle progression at a specific point in the cycle, after chromosome partitioning but before cytokinesis. Possible functions for Era in cell cycle progression and the initiation of cell division are discussed.
Full‐duplex MIMO system based on antenna cancellation technique (2014)

The performance of an antenna cancellation technique for a multiple‐input–multiple‐output (MIMO) full‐duplex system that is based on null‐steering beamforming and antenna polarisation diversity is investigated. A practical implementation of a symmetric antenna topology comprising three dual‐polarised patch antennas operating at 2.4 GHz is described. The measurement results show an average of 60 dB self‐interference cancellation over 200 MHz bandwidth. Moreover, a decoupling level of up to 22 dB is achieved for MIMO multiplexing using antenna polarisation diversity. The performance evaluation of the proposed technique was performed by simulation and measurement and the results have good agreement.
Face recognition using early biologically inspired features (2013)

Biologically inspired model (BIM) is proven to be an effective feature representation approach for visual object categorization. In BIM, two successive S(simple)-to-C(complex) hierarchical layers are performed to simulate the visual perception process of primate visual cortex. However, the intensive computational cost above C1 layer in BIM extremely limits its application in real-time object recognition tasks. This paper proposes to use a set of improved early biologically inspired features (EBIF, including S1 and C1) for face recognition, in which pyramidal statistics of mean and standard deviation rather than MAX pooling are used for scale-tolerant feature condensation and local normalization is performed on C1 layer. Incremental PCA (Principal Component Analysis) and LDA (Linear Discriminant Analysis) are then combined to efficiently learn a discriminant subspace for feature dimensionality reduction. In the matching stage, Cosine similarity is adopted as the distance metric for a given face pair. Experimental results on two public face datasets and a mobile face dataset show the effectiveness of the proposed method.
The gamma-Protocadherins regulate the survival of GABAergic interneurons during developmentally-regulated cell death (2020)

SUMMARY Inhibitory interneurons integrate into developing circuits in specific ratios and distributions. In the cortex, the formation of inhibitory networks occurs concurrently with the apoptotic elimination of a third of GABAergic interneurons. The molecular mechanisms that select GABAergic interneurons to survive or die are unknown. Here we report that the clustered Protocadherins regulate GABAergic cell survival in the developing brain. Deletion of the Pcdh-gamma genes (Pcdhgs) from GABAergic neurons in mice causes a severe loss of inhibitory neurons in multiple brain regions and results in motor deficits and seizure activities. By focusing on the neocortex and cerebellar cortex, we demonstrate that GABAergic interneuron loss results from elevated apoptosis during the postnatal wave of Bax- dependent programmed cell death. Pro-survival AKT signals are reduced in Pcdhg- deficient interneurons, diminishing the intrinsic capacity of interneurons to compete and incorporate into developing networks. We propose that the Pcdhgs mediate selective GABAergic interneuron survival to contribute to the formation of balanced inhibitory networks.
Techniques for Minimizing the Basal Plane Dislocation Density in SiC Epilayers to Reduce V<sub>f</sub> Drift in SiC Bipolar Power Devices (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
The United States Critical Illness and Injury Trials Group: An Introduction (2009)

The US Critical Illness and Injury Trials Group is funded to engage the relevant scientific communities and federal agencies to jointly advocate for clinical research. An inclusive, nationwide network of experts has been created to establish national priorities and pursue a strategic plan in conjunction with professional societies and existing research networks. Investigator-initiated clinical proposals will be presented and discussed at the inaugural National Institutes of Health meeting to promote collaboration and establish working groups to develop projects and core resources. Future US Critical Illness and Injury Trials Group meetings will convene triannually, providing a venue to gauge progress on strategic deliverables, foster development of the clinical projects, discuss education and training in clinical trial design, and address the ethical, legal, and social implications of research in the critically ill or injured patients.
Discovery of nitroaryl urea derivatives with antiproliferative properties (2015)

A series of urea derivatives bearing nitroaryl moiety has been synthesized and assayed for their potential antiproliferative activities. Some of the tested compounds displayed activity in RK33 laryngeal cancer cells and TE671 rhabdomyosarcoma cells while being generally less toxic to healthy HSF human fibroblasts cells. One compound was demonstrated to be a moderate CDK2 inhibitor with IC50 = 14.3 µM. Its structure was solved by an X-ray crystallography and molecular modelling was performed to determine structure-activity relationship. Obtained compounds constitute novel structures and generally demonstrated greater cytotoxicity in comparison to cisplatin. This study offers new structural motifs with potential for further development.