gebhart/patrepeval huggingface dataset:
Profile: Patrick Soon-Shiong (2011)

Dr Patrick Soon-Shiong is the Executive Director of the UCLA Wireless Health Institute, and Professor of Microbiology, Immunology, Molecular Genetics and Bioengineering at UCLA. He is a fellow of both the American College of Surgeons and the Royal College of Physicians and Surgeons of Canada. He serves on the Board of Directors for the National Institute of Transplantation, the Technology Council for the Center for Cancer Nanotechnology Excellence at Northwestern University, which is part of the National Cancer Institute&apos;s (NCI) five-year initiative for nanotechnology in cancer research. He serves on the RAND Health Board of Advisors and the President&apos;s Council at RAND, the Board of Trustees for the Saint John&apos;s Health Center, the Advisory Board of the California NanoSystems Institute at UCLA, the Advisory Board for the Institute for Technology Advancement (ITA) at UCLA School of Engineering, the Board of Councillors of the USC Viterbi School of Engineering, and the Arizona Commerce Authority Board. He is a founding board member of the Dossia Foundation, a non-profit consortium of large employers (Wal-Mart, AT&amp;T, BP America, Intel, Pitney Bowes, Cardinal Health, Sanofi-Aventis, Applied Materials, and Vanguard) that seek to enhance consumer engagement in their own healthcare through use of personal health records. In 2009, he was appointed by Attorney General Cuomo to the board of FAIR Health, a new not-for-profit entity to facilitate nationwide reform of consumer reimbursement for out of network healthcare charges.
A New Bioassay Using Transient Transfection for Invasion-Related Gene Analysis (1998)

To understand the mechanisms of tumor invasion and metastasis, model systems are required that isolate the individual steps of these complicated, multifaceted processes. We propose a new procedure to identify genes involved in cell invasion and/or motility that features the combined advantages of transient gene transfection and Matrigel invasion assays. Cancer cells were transiently cotransfected with two vectors expressing the gene of interest and luciferase, as a marker of transfected cells, and then assayed for Matrigel invasion. Luciferase cotransfection appeared to be a sensitive semiquantitative assay for transfected cells and was maximal throughout the invasion assay. The proposed transfection procedure, using calcium phosphate precipitation, did not affect cell invasiveness and allowed cellular coexpression of both genes. When applying this method, we found that transient expression of the unliganded and liganded human estrogen receptor alpha prevented invasiveness of MDA-MB-231 breast cancer cells. In conclusion, we propose rapid and versatile in vitro procedure for studying the effects of individual cloned genes on cellular processes, such as invasion and motility.
New Designs of Macroporous Polymers and Supports: From Separation to Biocatalysis (1996)

Reactive polymers play many roles, from supports for solid-phase synthesis or catalysis to media for separations. Although macroporous polymer beads that provide high reactive capacities and excellent solvent tolerance are well established, approaches to monosized beads with optimized pore structures or multiple chemistries segregated within pores of different sizes have expanded their realm of application. Polymer monoliths containing intricate pore networks can be obtained in any desired shape by a simple molding process and provide unique advantages such as fast kinetics, high reactivity, and high throughput. Applications ranging from immobilized enzyme reactors to fast media for the separation of synthetic or biopolymers are presented.
Supplementary Table 2 from Succinate Dehydrogenase Mutation Underlies Global Epigenomic Divergence in Gastrointestinal Stromal Tumor (2023)

&lt;p&gt;Supplementary Table 2 XLSX file 490K, Illumina GoldenGate Methylation Standard Cancer Panel I Target CpG Annotations and differential methylation significance values for group comparisons listed in Table&lt;/p&gt;
ChemInform Abstract: The Regiospecific p‐Deiodination of 2,4‐Diiodophenols. A New Synthesis of Aflatoxin B2. (1990)

Abstract Tosylation of the phenol (I) and subsequent oxidative cyclization yield the furobenzofuran derivative (III) which is detosylated to form the phenol (IV).
Arrhythmia and Acute Coronary Syndrome Suppression and Cardiac Resuscitation Management With Bretylium (2009)

It is well known that electric shock can both initiate and terminate ventricular fibrillation. Refractory ventricular fibrillation (RVF) may often be an iatrogenic paradoxical result of early, frequent, excessive salvos of DC current countershocks and inappropriate off-label drug use, particularly aggressive epinephrine administration. Evidence suggests that the current advanced cardiac life support pharmacology protocol for cardiac resuscitation may contribute to disappointing survival in patients with out-of-hospital cardiac arrest. Controlled studies and new theoretical consideration suggest the protocol may induce RVF. In contrast, studies suggest that immediate adequate intravenous bretylium administration therapy together with sustained effective chest compressions can induce chemical defibrillation or facilitate electrical defibrillation as well as reduce the intensity, or even need for potentially heart-damaging countershock, where early frequent excessive current shocks are likely to increase refractory arrhythmia as demonstrated in animals and in humans. Salvos of shocks do not allow time between shocks for uniform recovery of normal electrical parameters needed to restore a stable heart rhythm. This may occur by inadvertently administering shock during the vulnerable period of the cardiac cycle. There are compelling existing data to demonstrate that bretylium and cardiopulmonary resuscitation (CPR) delivered before initiating shock therapy is likely to provide the best outcome in cardiac arrest. But, most importantly, adequate CPR chest compressions administered while bretylium is being infused also provide the opportunity to wash out electrically destabilizing electrolytes that have leaked from or are abnormally transported by functionally damaged membranes of fibrillation-induced ischemic myocytes. This may cause abnormal compartment redistribution of electrolytes that may facilitate RVF by heterogeneously partially depolarizing ischemic myocytes. Although efforts have been made to provide hard science for advanced life support, the guidelines are a product of consensus, the give and take of collegiality and intuition rather than rigorous controlled studies. Bretylium has a direct antifibrillatory action normalizing myocyte membrane currents, which restores intracompartmental normal electrolyte balance. In addition, adrenergic blockade by bretylium dilates coronary arteries, increasing effective O2 delivery by CPR. The free and aggressive use of epinephrine is toxic. Catechalomines cause coronary spasm and puts myocardial metabolism into damaging hypermetabolic overdrive to support the "fight or flight reflex" rapidly depleting adenosine triphosphate needed for cardiac electrical and mechanical recovery. Moreover, the value of epinephrine to resuscitation has never been demonstrated in a controlled human study, whereas its potential damage has been largely ignored. Epinephrine's potential deleterious actions that might compromise resuscitation are well established and reviewed here.
ChemInform Abstract: CHEMISTRY OF ETHYLENIMINE. XII. TRANSFORMATIONS OF 1‐CHLORO‐1‐CYANO‐2‐(2,2‐DIMETHYLHYDRAZINO)ETHANE IN THE PRESENCE OF SODIUM HYDRIDE (1976)

Abstract Das Chlor‐cyan‐hydrazino= äthan (I) ergibt bei der Umsetzung mit Natriumhydrid in Tetrahydrofuran bei 0°C ein Gemisch der Verbindungen (II)‐(VI), deren Bildungsweise diskutiert wird.
Aldosterone Jeopardizes Myocardial Insulin and β-Adrenergic Receptor Signaling via G Protein-Coupled Receptor Kinase 2 (2019)

Hyperaldosteronism alters cardiac function, inducing adverse left ventricle (LV) remodeling either <i>via</i> increased fibrosis deposition, mitochondrial dysfunction, or both. These harmful effects are due, at least in part, to the activation of the G protein-coupled receptor kinase 2 (GRK2). In this context, we have previously reported that this kinase dysregulates both β-adrenergic receptor (βAR) and insulin (Ins) signaling. Yet, whether aldosterone modulates cardiac Ins sensitivity and βAR function remains untested. Nor is it clear whether GRK2 has a role in this modulation, downstream of aldosterone. Here, we show <i>in vitro</i>, in 3T3 cells, that aldosterone impaired insulin signaling, increasing the negative phosphorylation of insulin receptor substrate 1 (<sup>ser307</sup>pIRS1) and reducing the activity of Akt. Similarly, aldosterone prevented the activation of extracellular signal-regulated kinase (ERK) and the production of cyclic adenosine 3',5'-monophosphate (cAMP) in response to the β<sub>1</sub>/β<sub>2</sub>AR agonist, isoproterenol. Of note, all of these effects were sizably reduced in the presence of GRK2-inhibitor CMPD101. Next, in wild-type (WT) mice undergoing chronic infusion of aldosterone, we observed a marked GRK2 upregulation that was paralleled by a substantial β1AR downregulation and augmented <sup>ser307</sup>pIRS1 levels. Importantly, in keeping with the current <i>in vitro</i> data, we found that aldosterone effects were wholly abolished in cardiac-specific GRK2-knockout mice. Finally, in WT mice that underwent 4-week myocardial infarction (MI), we observed a substantial deterioration of cardiac function and increased LV dilation and fibrosis deposition. At the molecular level, these effects were associated with a significant upregulation of cardiac GRK2 protein expression, along with a marked β1AR downregulation and increased <sup>ser307</sup>pIRS1 levels. Treating MI mice with spironolactone prevented adverse aldosterone effects, blocking GRK2 upregulation, and thus leading to a marked reduction in cardiac <sup>ser307</sup>pIRS1 levels while rescuing β1AR expression. Our study reveals that GRK2 activity is a critical player downstream of the aldosterone signaling pathway; therefore, inhibiting this kinase is an attractive strategy to prevent the cardiac structural disarray and dysfunction that accompany any clinical condition accompanied by hyperaldosteronism.
The Thumb of the Anthropomorphic Awiwi Hand: From Concept to Evaluation (2014)

The impressive manipulation capabilities of the human hand are undoubtedly related to the thumb opposition. Such a versatility is highly desirable in the context of humanoid robots, in particular when performing object manipulation. In the present case, a robotic hand with size, forces, velocity, and shape comparable to the human one, is envisioned. Unlike most robotic designs — where the fingers are modular and the thumb is simply a finger placed in opposition — the thumb benefits from an intensive functional analysis. This paper details the design method of the thumb of the Awiwi hand, the hand of the Integrated Hand Arm System project of DLR. First, several guidelines are presented that are fused and, with the help of a novel optimization method, lead to the final design. Finally, the design is evaluated by the means of biomedical tests on the realized hardware.
Unusual Redox Behavior of .alpha.-Oligoheteroaromatic Compounds: An Increasing First Oxidation Potential with Increasing Conjugation Length (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleUnusual Redox Behavior of .alpha.-Oligoheteroaromatic Compounds: An Increasing First Oxidation Potential with Increasing Conjugation LengthJ. A. E. H. van Haare, L. Groenendaal, H. W. I. Peerlings, E. E. Havinga, J. A. J. M. Vekemans, R. A. J. Janssen, and E. W. MeijerCite this: Chem. Mater. 1995, 7, 10, 1984–1989Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://pubs.acs.org/doi/10.1021/cm00058a033https://doi.org/10.1021/cm00058a033research-articleACS PublicationsRequest reuse permissionsArticle Views287Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
XUV generation in pulsed free jets: Theory of operation and application to H2 detection (1984)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation A. H. Kung, N. A. Gershenfeld, C. T. Rettner, D. S. Bethune, E. E. Marinero, R. N. Zare; XUV generation in pulsed free jets: Theory of operation and application to H2 detection. AIP Conf. Proc. 1 September 1984; 119 (1): 10–22. https://doi.org/10.1063/1.34652 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
THE IN VITRO ANTIOXIDANT ACTIVITY AND TOTAL PHENOLIC CONTENT OF FOUR INDIAN MEDICINAL PLANTS (2009)

Methanolic extracts of Plumbago zeylanica (Root), Acorus calamus (Rhizome), Hemidesmus indicus (Stem) and Holarrhena antidysenterica (Bark), used in Ayurvedic medicines for number of ailments were evaluated for their antioxidant activity by ferric thiocyanate (FTC) assay and compared with thiobarbituric acid (TBA) method. The order of antioxidant potential according to FTC assay was found to be highest in Plumbago zeylanica followed by Holarrhena antidysenterica, Acorus calamus and Hemidesmus indicus. Whereas there is slightly difference in activities as measured by TBA method. The antioxidant activity of medicinal plants was at par with the commercial antioxidant butylated hydroxy toluene (BHT), L-Ascorbic acid and αtocopherol. Further, the radical-scavenging activity of the extracts was measured as decolourizing activity followed by the trapping of the unpaired electron of DPPH. The percentage decrease of 1, 1-diphenyl-2-picryl hydrazyl radical (DPPH) standard solution was recorded maximum for Hemidesmus indicus (77.0%) followed by Plumbago zeylanica (73.41%), Acorus calamus (20.88%) and Holarrhena antidysenterica (20.06%) extracts at a concentration of 100 µg/ml. Phytochemical analysis revealed the presence of major phytocompounds like alkaloids, glycosides, phenolics and saponins. Moreover, total phenolics concentration equivalents to gallic acid was found in the range of 59.50 to 109.0 mg/g of plant extracts, which correlated with antioxidant activity. The findings indicated promising antioxidant activity of crude extracts of the above plants and needs further exploration for their effective use in both modern and traditional system of medicines.
An LFT approach to parameter estimation (1997)

We consider a unified framework for parameter estimation problems which arise in a system identification context. In this framework, the parameters to be estimated appear in a linear fractional transform (LFT) with a known constant matrix M. Through the addition of other nonlinear or time-varying elements in a similar fashion, this framework is capable of treating a wide variety of identification problems. In this paper, we consider both output error and maximum likelihood cost functions. Using the structure of the problem, we are able to compute the gradient and the Hessian directly, without inefficient finite-difference approximations. Since the LFT structure is general, it allows one to consider issues such as identifiability and persistence of excitation for a large class of model structures, in a single unified framework. Within this framework, there is no distinction between "open-loop" and "closed-loop" identification.
Search for the rare decays B[superscript 0] → J/ψγ and B[0 over s] → J/ψγ (2015)

A search for the rare decay of a B[superscript 0] or B[0 over s] meson into the final state J/ψγ is performed, using data collected by the LHCb experiment in pp collisions at √s = 7 and 8 TeV, corresponding to an integrated luminosity of 3 fb[superscript -1]. The observed number of signal candidates is consistent with a background-only hypothesis. Branching fraction values larger than 1.5×10[superscript -6] for the B[superscript 0] → J/ψγ decay mode are excluded at 90% confidence level. For the B[0 over s] → J/ψγ decay mode, branching fraction values larger than 7.3×10[superscript -6] are excluded at 90% confidence level; this is the first branching fraction limit for this decay.
Search for a Higgs boson decaying into a Z and a photon in pp collisions at s=7 and 8 TeV (2013)

A search for a Higgs boson decaying into a Z boson and a photon is described. The analysis is performed using proton–proton collision datasets recorded by the CMS detector at the LHC. Events were collected at center-of-mass energies of 7 TeV and 8 TeV, corresponding to integrated luminosities of 5.0fb−1 and 19.6fb−1, respectively. The selected events are required to have opposite-sign electron or muon pairs. No excess above standard model predictions has been found in the 120–160 GeV mass range and the first limits on the Higgs boson production cross section times the H→Zγ branching fraction at the LHC have been derived. The observed at 95% confidence level limits are between about 4 and 25 times the standard model cross section times the branching fraction. For a standard model Higgs boson mass of 125 GeV the expected limit at the 95% confidence level is 10 and the observed limit is 9.5. Models predicting the Higgs boson production cross section times the H→Zγ branching fraction to be larger than one order of magnitude of the standard model prediction are excluded for most of the 125–157 GeV mass range.
Enhanced SAR Maps: Expanding the Data Rendering Capabilities of a Popular Medicinal Chemistry Tool (2009)

We recently introduced SAR maps, a new interactive method for visualizing structure-activity relationships targeted specifically at medicinal chemists. A SAR map renders an R-group decomposition of a congeneric series as a rectangular matrix of cells, each representing a unique combination of R-groups color-coded by a user-selected property of the corresponding compound. In this paper, we describe an enhanced version that greatly expands the types of visualizations that can be displayed inside the cells. Examples include multidimensional histograms and pie charts that visualize the biological profiles of compounds across an entire panel of assays, forms that display specific fields on user-defined layouts, aligned 3D structure drawings that show the relative orientation of different substituents, dose-response curves, images of crystals or diffraction patterns, and many others. These enhancements, which capitalize on the modular architecture of its host application Third Dimension Explorer (3DX), allow the medicinal chemist to interactively analyze complex scaffolds with multiple substitution sites, correlate substituent structure and biological activity at multiple simultaneous dimensions, identify missing analogs or screening data, and produce information-dense visualizations for presentations and publications. The new tool has an intuitive user interface that makes it appealing to experts and nonexperts alike.
Towards a fast microwave tomography system for multiphase flow imaging (2017)

Microwave tomography (MWT) is an imaging method that has been investigated as alternative technique for industrial process monitoring and multiphase flow imaging. These applications require data acquisition units with a high measurement rate in conjunction with a high dynamic range and a wide frequency range at reasonable costs, which is one major challenge designing MWT systems. In this work, we present a MWT system concept including a parallel hardware architecture which potentially allows for a measurement rate greater than 100 measurement cycles per second. We realized a 2-channel prototype electronics which allows for fast and precise single-frequency transmission parameter measurements in frequency range from 0.7 GHz to 5.5 GHz achieving a dynamic range of approximately 75 dB at a data acquisition time of 1 ms. In order to investigate the applicability of the prototype electronics for multiphase flow imaging, we conducted measurements using an 8-port MWT sensor and a 2 × 8 switching matrix. Qualitative approximations of the permittivity distributions in case of different static dielectric phantoms modeling oil-gas-water flow distributions were successfully reconstructed.
Selective Catalytic Reduction of NO with Fatty Acid Methyl Ester as Reductant over Ag/Al<sub>2</sub>O<sub>3</sub> Catalyst (2009)

Selective reduction of NO using fatty acid methyl esters (FAMEs) as the reducing agents was investigated over 3 wt% Ag/Al2O3 catalyst. NO reduction with C6-C14 saturated FAMEs showed volcano-type temperature dependence, as NO reduction started at around 250°C, reached the maximum at around 400°C, and then decreased at higher temperatures. NO reduction efficiency increased slightly as the fatty acid chain length decreased. The efficiency of saturated FAME for selective catalytic reduction is superior to that of the corresponding unsaturated FAME. The catalysts showed stable activity at temperatures above 350°C, but deactivated with time due to coking below 300°C. The performance of selective NO reduction with saturated FAME was roughly equal to that with n-decane and n-hexadecane.