gebhart/patrepeval huggingface dataset:
A flow cytometric analysis of 23 carcinoid tumors (1988)

Twenty-three carcinoid tumors were investigated from paraffin-embedded tissue with flow cytometry (FCM) in order to correlate the DNA ploidy with clinical variables. DNA aneuploidy was found in ten tumors (45%) and one tumor was classified as tetraploid. Diurnal urinary excretion of 5-hydroxy indolic acetic acid (5-HIAA) was known to be elevated in seven of eight diploid tumors and in four of seven aneuploid carcinoids with distant metastases. Six (55%) of the diploid tumors had not given rise to metastases at the time of diagnosis, compared with three (30%) of the aneuploid tumors. Six of seven patients with an aneuploid tumor and three of five patients with a diploid tumor, observed for at least 10 years, died of the disease. It was concluded that, unlike in earlier studies with static DNA cytometry, DNA aneuploidy is common in human carcinoid tumors and may occur in tumors secreting biogenic amines.
Reversible Light-, Thermo-, and Mechano-Responsive Elastomeric Polymer Opal Films (2013)

A new strategy to achieve easily scalable triple stimuli-responsive elastomeric opal films for applications as stretch-tunable photonic band gap materials is reported. Novel monodisperse highly functional core-interlayer-shell beads are obtained by semicontinuous emulsion polymerization featuring a temperature-sensitive fluorescent rhodamine dye either locally restricted in the core or the shell of prepared beads. After extrusion and compression molding, homogeneous elastomeric opal films with fascinating stretch-tunable and temperature-dependent fluorescent properties can be obtained. Applying strains of only a few percent lead to significant blue shift of the reflected colors making these films excellent candidates for applications as deformation sensors. Higher strains up to 90% lead to a tremendous Bragg reflection color change caused by transition from the (111) to the (200) lattice plane. The well-ordered opaline structure with its stop band at the emission frequency of the incorporated fluorescent dye shows remarkable angle-dependent fluorescence suppression. Herein described elastomeric opal films can be valuable in a wide range of applications such as rewritable 3D optical data storage, tunable laser action, and sensing materials.
A 50 Gbps 9.5 pJ/bit VCSEL-based Optical Link (2021)

We present an 850 nm VCSEL-based NRZ optical link operating at 50 Gbps. The full link uses no external equalization and has a power efficiency of 9.5 pJ/bit.
Thermal Properties (2008)

No AccessPlastics Testing and CharacterizationMar 2008Thermal PropertiesAlberto Naranjo, María del Pilar Noriega E., Tim A. Osswald, Alejandro Roldán-Alzate, Juan Diego SierraAlberto Naranjo, María del Pilar Noriega E., Tim A. Osswald, Alejandro Roldán-Alzate, Juan Diego Sierrahttps://doi.org/10.3139/9783446418530.004SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2008Pages: 75-126Print ISBN: 978-3-446-41315-3eISBN: 978-3-446-41853-0 Copyright & Permissions© 2008 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Agrobacterium-mediated T-DNA insertion for mutagenesis assessed by the production of hairy roots emitting melon fruit odours (2016)

ISHS International Symposium on Biotechnology and Other Omics in Vegetable Science Agrobacterium-mediated T-DNA insertion for mutagenesis assessed by the production of hairy roots emitting melon fruit odours
Spatial correlation of the EC-0.57 eV trap state with edge dislocations in epitaxial n-type gallium nitride (2018)

Defects in semiconductors lead to deleterious effects in electron devices, but identifying their physical sources can be difficult. An example of this in gallium nitride (GaN) high electron mobility transistors is the well-known trap state located at approximately EC-0.57 eV. This trap is strongly correlated with output power degradation and reliability issues, but despite two decades of study, its specific physical source is still unknown. To address this long-standing question, two complementary nm-resolution characterization techniques—scanning probe deep level transient spectroscopy (SP-DLTS) and electron channeling contrast imaging (ECCI)—were used to spatially map the lateral distribution of these traps and to image and characterize their relation to residual threading dislocations within NH3-MBE-grown n-type GaN. Direct comparison of the SP-DLTS and ECCI measurements on the same sample region reveals highly localized concentrations of EC-0.57 eV traps that are spatially correlated with pure edge type threading dislocations in the GaN, but not with mixed and/or screw type dislocations, indicating that the specific dislocation character is a defining factor for this particular defect level. This work demonstrates the efficacy of combining these two techniques to obtain energy-, location-, and structure-resolved characterization of defects in a functional device structure.
Ultrasound-enhanced drug delivery for cancer (2012)

Acoustic cavitation is found to play a potentially key role both in achieving targeted drug release and enhanced extravasation at modest pressure amplitudes and acoustic energies, whilst simultaneously enabling real-time monitoring of the drug delivery process. The next challenge in ultrasound-enhanced drug delivery will thus be to develop a new generation of drug-carrying nanoparticles which are of the right size range for delivery to tumours, yet still capable of achieving initiation of cavitation activity and drug release at modest acoustic pressures and energies that have no safety implications for the patient.
A Pauson−Khand Approach to the Synthesis of Ingenol (2005)

[reaction: see text] Pauson-Khand cyclization of dioxanone photoadduct 21 leads to the formation of a single product in good yield. However, retro-aldol fragmentation of the pentacyclic cyclopentenone 22 leads to the formation of 23, with cis C-8/C-10 intrabridgehead stereochemistry, unlike the target compound ingenol 1, which possesses C-8/C-10 trans intrabridgehead stereochemistry.
A multilevel model of XeF ground state kinetics (1980)

We present a multilevel model of energy transfer in the XeF ground electronic state due to collision-induced VT and dissociation processes. The model, whose parameters are based on experimental results presented here and on other recent data, should be useful in accurate simulations of output efficiency and multiline laser oscillation in XeF. Effective lifetimes of individual ground state levels, applicable to two-level laser models, are determined from the multilevel model. The effective lifetime of the primary lower laser level <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\upsilon" = 3</tex> is determined to be 4-6 ns for a 1 atm He buffer.
Stereocontrolled total synthesis of (+)-vincristine (2004)

An efficient total synthesis of (+)-vincristine has been accomplished through a stereoselective coupling of demethylvindoline and the eleven-membered carbomethoxyverbanamine presursor. Demethylvindoline was prepared by oxidation of 17-hydroxy-11-methoxytabersonine, followed by regioselective acetylation with mixed anhydride method. Although an initial attempt of coupling by using demethylvindoline formamide was not successful and resulted in recovery of the starting compounds, the reaction using demethylvindoline took place smoothly to furnish the desired bisindole product with the correct stereochemistry at C18'. After formation of the piperidine ring by sequential removal of the protective groups and intramolecular nucleophilic cyclization, the total synthesis of vincristine was completed by formylation of N1.
Hybrid Electrochemical Power Sources for Onboard Applications (2007)

In this paper, the performance of a hybrid ultracapacitor and battery power source for onboard applications is examined. First, the behavior of the system is shown by means of a nonlinear analytical model, which is solved using a double time scale procedure; then, the performances of the source is experimentally validated through an 80-V prototype. In light of the interaction between the battery and ultracapacitor during the provision of a pulsing load, issues related to power peak, internal loss, and lifecycle are discussed. The aim of this paper is to define the design criteria for battery and ultracapacitor integration in compact and light systems.
Room-Temperature Micron-Scale Exciton Migration in a Stabilized Emissive Molecular Aggregate (2016)

We report 1.6 ± 1 μm exciton transport in self-assembled supramolecular light-harvesting nanotubes (LHNs) assembled from amphiphillic cyanine dyes. We stabilize LHNs in a sucrose glass matrix, greatly reducing light and oxidative damage and allowing the observation of exciton–exciton annihilation signatures under weak excitation flux. Fitting to a one-dimensional diffusion model, we find an average exciton diffusion constant of 55 ± 20 cm2/s, among the highest measured for an organic system. We develop a simple model that uses cryogenic measurements of static and dynamic energetic disorder to estimate a diffusion constant of 32 cm2/s, in agreement with experiment. We ascribe large exciton diffusion lengths to low static and dynamic energetic disorder in LHNs. We argue that matrix-stabilized LHNS represent an excellent model system to study coherent excitonic transport. Keywords: coherent exciton; exciton; exciton delocalization; exciton diffusion; J-aggregate; molecular aggregate
SmartPad (2003)

This paper introduces SmartPad, a new input device for mobile computers that is an enhanced physical keypad by a finger position sensor. This input device acts as a normal keypad for mobile devices, such as cellular phones, and also recognizes finger position on the keypad be before the user presses the key. This feature is used to recognize finger gesture on the keypad, and can also be used to give preview information to the user before the user actually pressing the key. This previewable function helps users to predict the effect of the action, and it is also helpful when the key definitions are frequently changed according to the context, such as in the case of universal commanders.
Relation between intestinal blood flow and oxygen uptake (1982)

In autoperfused and pump-perfused preparations of canine ileum, arterial pressure, venous outflow pressure, blood flow, and arteriovenous oxygen difference were measured while blood flow was altered either mechanically or by graded intra-arterial infusions of isoproterenol, adenosine, or 2,4-dinitrophenol. In pump-perfused preparations, mechanical alterations in blood flow resulted in opposite changes in arteriovenous oxygen difference, so that ileal oxygen uptake was independent of blood flow over the range of 30-140 ml.min-1.100 g-1. Only at flow rates below 30 ml.min-1.100 g-1 was oxygen uptake dependent on blood flow. Isoproterenol, adenosine, and dinitrophenol produced dose-dependent increases in blood flow under free-flow conditions and decreases in perfusion pressure under constant-flow conditions. Ileal oxygen uptake was not affected by isoproterenol, decreased by adenosine, and increased by dinitrophenol. The effects of these drugs on intestinal oxygen uptake are in accord with their effects on oxygen consumption in vitro. These results suggest that vasodilators will not alter intestinal oxygen uptake in autoperfused preparations in which oxygen uptake is independent of blood flow, unless they exert an effect on oxidative metabolism.
Aberrant DNA Methylation Patterns in Chronic Idiopathic Myelofibrosis. (2004)

Abstract Chronic idiopathic myelofibrosis (CIMF) is a clonal myeloproliferative disorder characterized by bone marrow fibrosis, angiogenesis and extramedullary hematopoiesis. No specific genetic defect underlying the disease has been identified so far. The spectrum of cytogenetic abnormalities in CIMF includes del (13q), del (20q) and partial trisomy 1q as well as abnormalities of chromosomes 1, 7 and 9. Hypermethylation of CpG islands within gene promoter regions is associated with transcriptional inactivation and represents an important mechanism of gene silencing in the pathogenesis of hematopoietic malignancies. This epigenetic phenomenon acts as an alternative to mutations and deletions to disrupt tumor suppressor gene function in cancerogenesis. In order to investigate the role of DNA methylation changes in the pathogenesis of CIMF, we have analyzed the methylation status of the promoter-associated CpG islands of 13 well-characterized tumor suppressor genes by methylation-specific polymerase chain reaction in peripheral blood cells from 20 adult patients with CIMF. The frequency of aberrant methylation among the patient samples was 25.0 % (5/20) for SOCS-1 and 5.0 % (1/20) for E-cadherin, MGMT, p73 as well as TIMP-2. There was no hypermethylation of p15, p16, RARbeta, DAP kinase 1, SOCS-3, hMLH1, TIMP-3 and RASSF1A. We detected at least one hypermethylated gene promoter region in 35.0 % (7/20) of the primary patient samples. Our data indicate that hypermethylation of tumor suppressor genes is a common event in CIMF. Epigenetic modification of genes regulating growth factor signaling, cell adhesion and DNA repair may, in addition to genetic aberrations, contribute to the malignant phenotype in CIMF. The exploration of our growing knowledge about epigenetic aberrations in tumorigenesis may help develop novel strategies in diagnosis and treatment of CIMF for the future.
Motility and adhesion through type IV pili in Gram-positive bacteria (2016)

Type IV pili are hair-like bacterial surface appendages that play a role in diverse processes such as cellular adhesion, colonization, twitching motility, biofilm formation, and horizontal gene transfer. These extracellular fibers are composed exclusively or primarily of many copies of one or more pilin proteins, tightly packed in a helix so that the highly hydrophobic amino-terminus of the pilin is buried in the pilus core. Type IV pili have been characterized extensively in Gram-negative bacteria, and recent advances in high-throughput genomic sequencing have revealed that they are also widespread in Gram-positive bacteria. Here, we review the current state of knowledge of type IV pilus systems in Gram-positive bacterial species and discuss them in the broader context of eubacterial type IV pili.
Multiscale BerEp4 Molecular Imaging of Microtumor Phantoms: Toward Theranostics for Basal Cell Carcinoma (2014)

Basal cell carcinoma (BCC), the most common cancer in humans, appears macroscopically and microscopically similar to many other skin lesions, which makes differential diagnosis difficult. We are developing an approach for quantitative molecular imaging of BerEP4, a transmembrane biomarker for BCC, with the goal of increasing the precision and accuracy of diagnosis. This pilot study was conducted to assess the affinity and selectivity of BerEp4 antibody and assess its possible use in designing theranostic probes for BCC. We provide evidence that our photon-counting fluorescence macrodetection system can recover specific signal increases from a film/pellet phantom. Additionally, we show that a two-photon excited fluorescence /backscatter confocal microscopy system can image BerEP4 antibody/antigen complex on the surface of BerEP4-expressing cancer cells in three dimensions. Based on the initial results, BerEP4 seems to be a promising biomarker for molecular imaging of BCC. To prepare BerEP4 for eventual theranostic use, we examined the feasibility of a combined macro-/micro-optical approach to imaging BCC with various histologies. These optical methods, endowed with the ability to monitor treatment in real time, may open an opportunity for noninvasive diagnosis, treatments, and follow-up.
Predicting the impact of expansion terms using semantic and user interaction features (2013)

Query expansion for Information Retrieval is a challenging task. On the one hand, low quality expansion may hurt either recall, due to vocabulary mismatch, or precision, due to topic drift, and therefore reduce user satisfaction. On the other hand, utilizing a large number of expansion terms for a query may easily lead to resource consumption overhead. As web search engines apply strict constraints on response time, it is essential to estimate the impact of each expansion term on query performance at the pre-retrieval time. Our experimental results confirm that a significant part of expansions do not improve query performance, and it is possible to detect such expansions at the pre-retrieval time.
Butterfly magnetoresistance, quasi-2D Dirac Fermi surface and topological phase transition in ZrSiS (2016)

Magnetoresistance (MR), the change of a material's electrical resistance in response to an applied magnetic field, is a technologically important property that has been the topic of intense study for more than a quarter century. We report the observation of an unusual "butterfly"-shaped titanic angular magnetoresistance (AMR) in the nonmagnetic Dirac material, ZrSiS, which we find to be the most conducting sulfide known, with a 2-K resistivity as low as 48(4) nΩ⋅cm. The MR in ZrSiS is large and positive, reaching nearly 1.8 × 10<sup>5</sup> percent at 9 T and 2 K at a 45° angle between the applied current (<i>I</i> || <i>a</i>) and the applied field (90° is <i>H</i> || <i>c</i>). Approaching 90°, a "dip" is seen in the AMR, which, by analyzing Shubnikov de Haas oscillations at different angles, we find to coincide with a very sharp topological phase transition unlike any seen in other known Dirac/Weyl materials. We find that ZrSiS has a combination of two-dimensional (2D) and 3D Dirac pockets comprising its Fermi surface and that the combination of high-mobility carriers and multiple pockets in ZrSiS allows for large property changes to occur as a function of angle between applied fields. This makes it a promising platform to study the physics stemming from the coexistence of 2D and 3D Dirac electrons as well as opens the door to creating devices focused on switching between different parts of the Fermi surface and different topological states.
The pH Modulation by Fungal Secreted pH Effecting Molecules: A Mechanism Affecting Pathogenicity and Mycotoxin Accumulation During Colonization by Penicillium expansum (2016)

This comprehensive book highlights current hot-topics in Aspergillus and Penicillium research. Topics include: use of genomics for forward genetics and genomic adaptations, taxonomy, virulence, carbon starvation, sulphur metabolism, feruloyl esterases, secondary metabolism and pH modulation, to the development of novel methodology for use in parallel to genome sequencing.
Interferon induction of IFITM proteins promotes infection by human coronavirus OC43 (2014)

IFNs are a family of cytokines that are essential for the antiviral response in vertebrates. Not surprisingly, viruses have adapted to encode virulence factors to cope with the IFN response. Intriguingly, we show here that all three types of interferons, IFN-α, IFN-γ, and IFN-λ, efficiently promote infection by a human coronavirus, HCoV-OC43, one of the major etiological agents of common cold, through the induction of IFN-inducible transmembrane (IFITM) proteins. IFITMs typically exert their antiviral function by inhibiting the entry of a broad spectrum of viruses into their host cells, presumably by trapping and degrading invading virions within the endocytic compartments. In contrast, HCoV-OC43 uses IFN-induced human IFITM2 or IFITM3 as an entry factor to facilitate its infection of host cells. Reverse genetics analyses suggest that the structural motifs critical for the IFITM proteins' enhancement of HCoV-OC43 infection are distinct from those required for inhibiting infection by other viruses. We also present evidence showing that IFITM family members work as homo- and hetero-oligomers to modulate virus entry. The observed enhancement of HCoV-OC43 infection by IFNs may underlie the propensity of the virus to invade the lower respiratory tract under inflammatory conditions.
Analysis of probability-density functions for laser scintillations in a turbulent atmosphere (1989)

We have reanalyzed a selection of data obtained from laser scintillation experiments in the light of recent criticisms of analysis techniques based on the moments of the data. In agreement with those criticisms, we find that comparing the higher moments of the data with those of model distributions can produce misleading results. We therefore use a least-squares fitting method to compare directly the experimental probability distributions with the models. The conclusion of the earlier experiments, that the K distribution is generally better than the log-normal distribution in the strong-scintillation regime, however, is not changed by the new analysis.
Non-thermal Plasma for Coke Elimination in an Aged Hydrotreating Catalyst: Comparison with a Coked Zeolite (2021)

The removal of coke from an aged industrial hydrodesulfurization catalyst, using DBD non-thermal plasma with a pin to plate geometry, was investigated. One of the most important processes in a refinery for removing sulfur-containing compounds is the hydrodesulfurization (HDS) process. The aged catalyst was introduced into the plasma reactor as a thin wafer. After 130 minutes of plasma treatment, with P=30W, 70% of coke was removed while more than 40% of sulfur was still present. Characterization of&nbsp; catalyst at different location of the wafer show that coke was more easily removed at the center, closed to the pin electrode where the electric field is more intense. The formation of an unexpected phase, under the plasma discharge, was highlighted, it corresponds to the family of Keggin HPA PMo12O403-, which could be an interesting precursor of catalyst for HDS process. Comparing with a coked zeolite, the rate of regeneration is lower for the HDS catalyst under plasma discharge, while a lower temperature is required under conventional thermal oxidation. It is explained by the presence of metal particles, which could be responsible for the limitation in O-atoms formation under plasma.
Reminiscences of Ben Hill (1906)

Research Article| April 01 1906 Reminiscences of Ben Hill John C. Reed John C. Reed Esq. Author of “The Brothers’ War” Search for other works by this author on: This Site Google South Atlantic Quarterly (1906) 5 (2): 134–149. https://doi.org/10.1215/00382876-5-2-134 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn MailTo Permissions Search Site Citation John C. Reed; Reminiscences of Ben Hill. South Atlantic Quarterly 1 April 1906; 5 (2): 134–149. doi: https://doi.org/10.1215/00382876-5-2-134 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsSouth Atlantic Quarterly Search Advanced Search The text of this article is only available as a PDF. Copyright © 1906 by Duke University Press1906 Article PDF first page preview Close Modal You do not currently have access to this content.
Effects of Aberrant Pax6 Gene Dosage on Mouse Corneal Pathophysiology and Corneal Epithelial Homeostasis (2011)

Pax6⁺/⁻ and PAX77(Tg/-) genotypes have only relatively minor effects on LESC clone numbers but cause more severe corneal endothelial and stromal defects. This should prompt further investigations of the pathophysiology underlying human aniridia and ARK.