gebhart/patrepeval huggingface dataset:
Multicomponent Magnetic Nanorods for Biomolecular Separations (2004)

Gold und Nickel sind die Bestandteile von Nanostäben zur Trennung von Biomolekülen. Die Stäbe können als ein Gerüst mit großer Oberfläche für biospezifische Erkennungsvorgänge in einer Vielzahl von Biotrennverfahren fungieren. Der magnetische Ni-Block bietet nicht nur Spezifität bezüglich His-markierter Proteine, sondern ermöglicht auch ein sehr einfaches Entfernen der Stäbe aus der Lösung mithilfe eines Magnetfeldes (siehe Schema). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2004/z54088_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A 60 GHz dual-mode amplifier in 65nm CMOS technology (2011)

A dual-mode power amplifier is designed in 65nm CMOS technology to have high efficiency at power back-off. It consists of two branches, one branch is a two-stage class A amplifier and the other is a three-stage class C amplifier. This amplifier has two different modes of operation at power back-off and at peak power. The main design issues for having high efficiency at output power back-off are discussed and considered in the design. Simulation results show a power-added efficiency of more than 13% at 5 dB output power range and 14.2dBm saturated output power.
Dehydration Induced by Bowel Preparation in Older Adults Does Not Result in Cognitive Dysfunction (2008)

Dehydration alone does not result in cognitive dysfunction.
Thermal Analysis and Durability Design Strategies for Gas Turbine Airfoils (2006)

Aircraft propulsion engines, land-based power generation, and industrial machines have, as a primary component, the turbine as means to produce thrust or generate power. In the turbine section of the engine, airfoil components are subjected to extremely complex and damaging environments. The combination of high gas temperatures and pressures, strong gradients, abrupt geometry changes, viscous forces, rotational forces, and unsteady turbine vane/blade interactions, all combine to offer a formidable challenge in terms of turbine durability. Nevertheless, the ultimate goal is to maintain or even improve the highest level of turbine performance and simultaneously reduce the amount of cooling flow needed to achieve this end. As such, coolant flow is a penalty to the cycle and thermal efficiency. Cooling strategies are developed and presented to determine ways for coolant flow management. The main variables include film cooling configurations, and convective efficiency schemes to balance turbine airfoil thermal loads for target overall cooling effectiveness. The desired targets are determined by the turbine airfoil durability requirements of oxidation and fatigue on a local scale and for creep on the bulk scale. Emphasis is provided to the general modes of cooling including film cooling, impingement cooling, and convective cooling for different parts of the airfoil such as leading edge, mid-body, trailing edge, tip and endwalls. Convective cooling is presented in terms of fundamental cooling enhancements, such as turbulating trip strips and pedestals. Recent literature dealing with these topics is listed.
Lycos Retriever (2006)

This paper describes the Lycos Retriever system, a deployed system for automatically generating coherent topical summaries of popular web query topics.
An experimental generator using high temperature superconducting quasi-permanent magnets (1995)

An experimental axial gap generator, with a 6 inch diameter rotor and quasi-permanent HTS magnets, was tested. A variable speed motor was used to rotate the rotor above a stator composed of copper wire wound in an 8 pole 3 phase configuration. The rotor and stator were both run in liquid nitrogen. A 3 phase variable resistor bank was the generator load. The HTS magnets were YBCO, each 2 cm in diameter and 1 cm thick, melt textured using a SmBCO seed, containing 60% excess Y, and about 1%Pt. They were not irradiated, and could trap maximum fields of 3500-4000 G. First, the HTS magnets were field cooled in a field of approximately 2200 G, provided by the stator while carrying 25 Amperes. The HTS magnets trapped about 1800 G. In this configuration, the generator was run for about one hour at speeds up to 2000 RPM, and developed a maximum power output of 33 Watts. Next the HTS magnets were warmed, and then zero field cooled. In this case, activation was accomplished by a /spl sim/15 ms pulse on the stator, providing 5000 G of pulsed field. The HTS magnets trapped about 2600 G. The generator was then run for about 1 hour at speeds up to 2265 RPM, and developed a maximum power output of just under 100 Watts.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Effect of metals and annealing on specific contact resistivity of GeTe/metal contacts (2012)

The circular transfer length method was employed to extract the specific contact resistivity, ρc of GeTe (amorphous and crystalline state) with metals (Ni, W, TiW) to quantify the series contact resistance. The ρc of amorphous-GeTe with metals was also determined for different annealing conditions. Higher metal work functions produce lower ρc for both GeTe states and the ρc was reduced further for annealing temperatures greater than the GeTe crystallization temperature. This is suggested to be a consequence of the higher temperature required to diffuse sufficient interstitial metallic atoms to transform the GeTe covalent bonding at the interface to metallic bonding.
Smart Integrated Charger with Wireless BMS for EVs (2018)

During the last 4-5 years the plug in electrical vehicle market has known a tremendous growth, only in 2017 307400 units were sold, representing an increase of 39%. The battery management system and the battery charger are two of the most demanding systems in terms of required computational power added to this type of vehicles. Also, features related to driving automation, safety and comfort are becoming more complex, therefore a higher level of integration is necessary. The objective of this paper is to integrate an intelligent wireless battery management system into the same system on chip as the battery charger and to prove that a single IC can parallelize and coordinate all tasks conventionally carried out by multiple dedicated processors. The proposed solution exhibits higher integration, improved balancing, increased reliability and extended range.
Advanced vehicle control systems (AVCS) research for automated highway systems in California PATH (2002)

This paper describes research on advanced vehicle control systems (AVCS) for automated highway systems (AHS) in the California PATH (Partners for Advanced Transit and Highways) program. After a brief introduction of the PATH and a review of the history of AHS, research in PATH at both the system level and the vehicle level control is reviewed. The PATH hierarchical AHS architecture consists of network, link, coordination and regulation layers. The regulation layer is supported by AVCS which consists of vehicle longitudinal control and lateral control.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Data from JNJ-26481585, a Novel Second-Generation Oral Histone Deacetylase Inhibitor, Shows Broad-Spectrum Preclinical Antitumoral Activity (2023)

Supplementary Data from JNJ-26481585, a Novel Second-Generation Oral Histone Deacetylase Inhibitor, Shows Broad-Spectrum Preclinical Antitumoral Activity
A codec for digital studio recording of HDTV (1992)

The digital recorder is one of the most important components in the HDTV studio. However, the main problem of digital HDTV recording is the enormous tape consumption, which is given by the high bit rate of HDTV signals and by the limited recording density of magnetic tape technology. A possible solution of this dilemma is the usage of digital source coding techniques, by which the input bit rate of HDTV signals can be compressed in order to increase the playing time up to 90 minutes and more. Therefore a research project was started at HHI in order to study the feasibility of VCR coding for studio applications. During this research project a DCT (discrete cosine transform) codec, which fulfils all the requirements of studio recording, has been developed on the basis of computer simulations. This DCT codec has recently been built up as experimental hardware system. The coding technique and VCR codec are described.
Antisense Oligonucleotides as Modulators of Pre-mRNA Splicing (2003)

Antisense oligonucleotides have been extensively used as downregulators of gene expression (1), and as such are not only increasingly used in various fields as sequence-specific research tools (2–4), but are also tested in clinical trials as antiviral and anticancer agents (5–8).
Profiling the effect of nafcillin on HA-MRSA D712 using bacteriological and physiological media (2019)

Staphylococcus aureus strains have been continuously evolving resistance to numerous classes of antibiotics including methicillin, vancomycin, daptomycin and linezolid, compounding the enormous healthcare and economic burden of the pathogen. Cation-adjusted Mueller-Hinton broth (CA-MHB) is the standard bacteriological media for measuring antibiotic susceptibility in the clinical lab, but the use of media that more closely mimic the physiological state of the patient, e.g. mammalian tissue culture media, can in certain circumstances reveal antibiotic activities that may be more predictive of effectiveness in vivo. In the current study, we use both types of media to explore antibiotic resistance phenomena in hospital-acquired USA100 lineage methicillin-resistant, vancomycin-intermediate Staphylococcus aureus (MRSA/VISA) strain D712 via multidimensional high throughput analysis of growth rates, bacterial cytological profiling, RNA sequencing, and exo-metabolomics (HPLC and LC-MS). Here, we share data generated from these assays to shed light on the antibiotic resistance behavior of MRSA/VISA D712 in both bacteriological and physiological media.
A Novel Micromachined Glow Plug for Ultrahigh Temperature Ignition Applications (2002)

This paper presents the design, fabrication and testing of a micro glow plug for ultrahigh temperature ignition applications. The device was fabricated from a novel refractory ceramic known as polymer-derived silicon carbon-nitride, which has been shown to possess outstanding mechanical robustness, corrosion resistance, and thermal shock resistance at temperatures exceeding 1000 o C. The micro glow plug has been shown to achieve temperatures of at least 1200 o C, with a response time of less than 1 second and with a power consumption of 3 Watts. In addition, the micro glow plug was used to ignite thermite in both chip-scale and macro-scale reactions.
Potential protective action of pituitary adenylate cyclase-activating polypeptide (PACAP38) on in vitro and in vivo models of myeloma kidney injury (2005)

The most common type of renal injury in multiple myeloma is chronic tubulointerstitial nephropathy associated with casts in tubule lumens, an entity referred to as "myeloma kidney" that often progresses to end-stage kidney diseases. Myeloma kidney is associated with a significant increase in all-cause mortality, yet no effective intervention, except a limited use of steroid, is available. Here, we report that pituitary adenylate cyclase-activating polypeptide with 38 residues (PACAP38) dramatically prevents injury of cultured renal proximal tubule cells caused by myeloma light chains through suppression of proinflammatory cytokines production, by inhibiting p38 MAPK and translocation of NFkappaB via both PAC(1) and VPAC(1) receptors. The suppressive effects of PACAP was as effective as dexamethasone in all of their cytokine assays and demonstrated both in vitro and in vivo. Furthermore, PACAP38 inhibits myeloma cell growth directly and may also indirectly by suppressing production of the growth factor, IL-6, from bone marrow stromal cells, that is stimulated by adhesion of myeloma cells. These findings render PACAP38 worth evaluation as a promising candidate for an effective and safe renoprotectant in myeloma kidney, and possibly other nephropathy, and also as a new antitumor agent in multiple myeloma.
ChemInform Abstract: Interfacial Enzymology: The Secreted Phospholipase A2‐Paradigm (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Urine Protease and Antiprotease Activity in Experimental Aminonucleoside Nephrotoxicity (1981)

Induction of nephrosis in rats with aminonucleoside of puromycin (ANP) was followed by an increase in urinary protease activity, measured by the cleavage of 14C-globin, as well as in antiprotease activity measured by trypsin inhibition. The excretion of protease and protease inhibitor coincided with but did precede the onset of proteinuria when the ANP was injected subcutaneously for 5 days and lagged after proteinuria when the ANP was given as a single intravenous dose. Serum protease activity did not change throughout ANP treatment or later, whereas serum antiprotease capacity declined coincidently with proteinuria, most probably due to the loss in urine. Kidney proteolytic activity was markedly reduced in ANP nephrosis. Treatment of rats with proteolysis inhibitors, trasylol, episilon-aminocaproic acid, soybean trypsin inhibitor, or hexapron, together with ANP failed to prevent, delay or reduce the proteinuria. We believe that the urinary protease in ANP nephrosis does not originate from the circulation but from the release of kidney protease as a consequence of the glomerular lesion, and does not appear to be involved in its causation.
Blind estimation of effective downlink channel gains in massive MIMO (2015)

We consider the massive MIMO downlink with time-division duplex (TDD) operation and conjugate beamforming transmission. To reliably decode the desired signals, the users need to know the effective channel gain. In this paper, we propose a blind channel estimation method which can be applied at the users and which does not require any downlink pilots. We show that our proposed scheme can substantially outperform the case where each user has only statistical channel knowledge, and that the difference in performance is particularly large in certain types of channel, most notably keyhole channels. Compared to schemes that rely on downlink pilots (e.g., [1]), our proposed scheme yields more accurate channel estimates for a wide range of signal-to-noise ratios and avoid spending time-frequency resources on pilots.
Sustained Notch2 signaling in osteoblasts, but not in osteoclasts, is linked to osteopenia in a mouse model of Hajdu-Cheney syndrome (2017)

Individuals with Hajdu-Cheney syndrome (HCS) present with osteoporosis, and HCS is associated with <i>NOTCH2</i> mutations causing deletions of the proline-, glutamic acid-, serine-, and threonine-rich (PEST) domain that are predicted to enhance NOTCH2 stability and cause gain-of-function. Previously, we demonstrated that mice harboring <i>Notch2</i> mutations analogous to those in HCS (<i>Notch2HCS</i>) are severely osteopenic because of enhanced bone resorption. We attributed this phenotype to osteoclastic sensitization to the receptor activator of nuclear factor-κB ligand and increased osteoblastic tumor necrosis factor superfamily member 11 (<i>Tnfsf11</i>) expression. Here, to determine the individual contributions of osteoclasts and osteoblasts to HCS osteopenia, we created a conditional-by-inversion (<i>Notch2<sup>COIN</sup></i> ) model in which Cre recombination generates a <i>Notch2</i><sup>Δ<i>PEST</i></sup> allele expressing a Notch2 mutant lacking the PEST domain. Germ line <i>Notch2<sup>COIN</sup></i> inversion phenocopied the <i>Notch2HCS</i> mutant, validating the model. To activate Notch2 in osteoclasts or osteoblasts, <i>Notch2<sup>COIN</sup></i> mice were bred with mice expressing Cre from the <i>Lyz2</i> or the <i>BGLAP</i> promoter, respectively. These crosses created experimental mice harboring a <i>Notch2</i><sup>Δ<i>PEST</i></sup> allele in Cre-expressing cells and control littermates expressing a wild-type <i>Notch2</i> transcript. <i>Notch2<sup>COIN</sup></i> inversion in <i>Lyz2</i>-expressing cells had no skeletal consequences and did not affect the capacity of bone marrow macrophages to form osteoclasts <i>in vitro</i> In contrast, <i>Notch2<sup>COIN</sup></i> inversion in osteoblasts led to generalized osteopenia associated with enhanced bone resorption in the cancellous bone compartment and with suppressed endocortical mineral apposition rate. Accordingly, <i>Notch2</i> activation in osteoblast-enriched cultures from <i>Notch2<sup>COIN</sup></i> mice induced <i>Tnfsf11</i> expression. In conclusion, introduction of the HCS mutation in osteoblasts, but not in osteoclasts, causes osteopenia.
Excitatory stimulation during postsynaptic inhibition induces long-term depression in hippocampus in vivo (1994)

1. As part of an effort to evaluate the biological plausibility of theoretically derived principles of synaptic modification, we studied activity-dependent long-term depression (LTD) of glutamatergic transmission in the hippocampus of anesthetized adult rats. Field potentials of CA1 pyramidal cells evoked by single-pulse stimulation (0.1 Hz) of the commissural afferents were recorded before and after paired-pulse stimulation (0.5 Hz) of the same pathway. A train of 150 or 200 paired pulses produced robust LTD of the commissural input to the CA1 pyramidal neurons when the interstimulus interval (ISI) of the pairs was short (25 ms) but not when the ISI was long (1,000 ms). 2. Paired-pulse stimulation with the short but not with the long ISI also was associated with pronounced inhibition of pyramidal cell firing upon the second pulse of a pair, despite the fact that the excitatory input was facilitated with the short-ISI paradigm. The inhibition of pyramidal cell activity was mediated by input to the pyramidal cells from local gamma-aminobutyric acid (GABA)-releasing interneurons activated by commissural fibers and/or CA1 recurrent collaterals, because the inhibition was eliminated by local administration of the selective GABAA receptor antagonist, bicuculline (50 microM), near the recording site. 3. Postsynaptic input from GABAergic interneurons was necessary for the induction of LTD, because short-ISI paired-pulse stimulation failed to produce LTD in the presence of bicuculline. 4. N-methyl-D-aspartate (NMDA) receptor-mediated excitation also was necessary for the induction of LTD, because administration of the selective NMDA receptor antagonist, D-2-amino-5-phosphonvaleric acid (100 microM), near the recording site prevented the development of LTD.(ABSTRACT TRUNCATED AT 250 WORDS)
Advanced 2.5D and 3D packaging technologies for next generation Silicon Photonics in high performance networking applications (2022)

We will discuss packaging solutions & assembly processes developed for next generation silicon photonics systems ranging from 100G to 800G, with a scalable path toward 1.6T & co-packaged optics. Focus will be on new device integration schemes, packaging architectures, and assembly processes geared toward high performance, high reliability networking applications. We will elaborate on these challenges & discuss various packaging innovations which, if optimized for application to photonics systems, can help scale next generation of silicon photonics devices and resolve critical issues toward increasing number of channels, data rate, & reduce power and cost per bit for future optics products, providing a path to co-packaged optics.
Activity of Exporters of <i>Escherichia coli</i> in <i>Corynebacterium glutamicum</i>, and Their Use to Increase <i>L</i>-Threonine Production (2008)

L-Threonine is an important biotechnological product and Corynebacterium glutamicum is able to synthesize and accumulate this amino acid to high intracellular levels. We here use four exporters of Escherichia coli and show that three of them operate in C. glutamicum, with RhtA and RhtC being the most effective. Whereas RhtA was unspecific, resulting in L-homoserine together with L-threonine excretion, this was not the case with RhtC. Expression of rhtC reduced the intracellular L-threonine concentration from 140 to 11 mM and resulted in maximal excretion rates of 11.2 nmol min(-1) mg(-1) as compared to 2.3 nmol min(-1) mg(-1) obtained without rhtC expression. In combination with an ilvA mutation generated and introduced into the chromosome, an accumulation of up to 54 mM L-threonine was achieved as compared to 21 mM obtained with the ancestor strain. This shows that expression of rhtC is the pivotal point for industrial relevant L-threonine production with C. glutamicum, and might encourage in general the use of heterologous exporters in the field of white biotechnology to make full use of biosynthesis pathways.
Three-Dimensional Bioprinting Applications for Bone Tissue Engineering (2023)

The skeletal system is a key support structure within the body. Bones have unique abilities to grow and regenerate after injury. Some injuries or degeneration of the tissues cannot rebound and must be repaired by the implantation of foreign objects following injury or disease. This process is invasive and does not always improve the quality of life of the patient. New techniques have arisen that can improve bone replacement or repair. 3D bioprinting employs a printer capable of printing biological materials in multiple directions. 3D bioprinting potentially requires multiple steps and additional support structures, which may include the use of hydrogels for scaffolding. In this review, we discuss normal bone physiology and pathophysiology and how bioprinting can be adapted to further the field of bone tissue engineering.
Osteosynthesis-Associated Bone Infection Caused by a Nonproteolytic, Nontoxigenic Clostridium botulinum -Like Strain (2004)

A nonproteolytic, nontoxigenic Clostridium botulinum strain identified by conventional and molecular techniques as type B-, E-, or F-like (BEF-like) was isolated from a human postsurgical wound. All previous reports of such strains have been from environmental sources. Since toxin production is the main taxonomic denominator for C. botulinum, a new name is needed for nonproteolytic, nontoxigenic BEF-like clinical isolates.
Comparison of Multipliers Architectures through Emulation and Handle-C FPGA Implementation (2006)

This paper presents a study that compares the architectures and study’s the performance of some of the major integer multiplication algorithms. This is achieved through a simulation environment that at this stage implements four major multipliers in C++ programming language and implements the same architectures in an FPGA prototype system. The environment is a flexible one and has a well-designed user interface that makes it suitable for educational use. It enables the user to emulate the multipliers for various data inputs and observe the type of operation being executed. Handle-C was used for synthesis and subsequently implementation of the multipliers in an FPGA. The multipliers involved in this study are Hennessy, carry save, ripple carry array and Wallace tree. The performance of each multiplier is assessed through a study of its area and real-time complexities.