gebhart/patrepeval huggingface dataset:
Application of hopfield-type neural network to switch planning problem of power distribution system. (1991)

This paper presents a new application method of Hopfield-type neural networks for combinatorial optimization problems under inequality constraints. Since Hopfield showed that the neural network technique could solve combinatorial problems such as the Traveling Salesman Problem, many researchers have attemped to apply the neurals networks to various problems. However, the constraints of almost all of those problems are limited to equality constraints. To deal with the inequality constraints, we developed a new method in which we introduce special neurons that converge to intermediate values between 0 and 1. This method is applied to the switch pattern planning problem of power distribution systems. The stability analysis and simulation results show that the method is quite promising.
Repurposing Quinacrine against Ebola Virus Infection In Vivo (2019)

Quinacrine hydrochloride is a small-molecule, orally bioavailable drug that has been used clinically as an antimalarial and for many other applications. A machine learning model trained on Ebola virus (EBOV) screening data identified quinacrine as a potent (nanomolar) <i>in vitro</i> inhibitor. In the current study, quinacrine 25 mg/kg was shown to protect 70% of mice (statistically significant) from a lethal challenge with mouse-adapted EBOV with once-daily intraperitoneal dosing for 8 days.
Figure S6 from Gamma Secretase Inhibition by BMS-906024 Enhances Efficacy of Paclitaxel in Lung Adenocarcinoma (2023)

&lt;p&gt;Mechanisms of enhanced paclitaxel-induced apoptosis and proliferation inhibition by BMS-906024.&lt;/p&gt;
Repair of the flexor pollicis longus tendon in children (2000)

This is a retrospective study of primary repairs of flexor pollicis longus in 16 children under 15 years of age. Patients with injuries to the median or ulnar nerve at the wrist, crush injuries, skin loss or fracture were excluded. Repairs were carried out within 24 hours using a modified Kessler technique. The mean follow-up was for two years. The final results were evaluated using the criteria of Buck-Gramko and Tubiana. They were good or excellent in all except one patient who had a secondary tendon rupture. When compared with the non-injured thumb, however, there was a significant decrease in active interphalangeal flexion (> 30 degrees) in one-third of cases. A new method of assessment is proposed for the recovery of function of the flexor pollicis tendon which is more suitable for children. Postoperative immobilisation using a short splint had a negative effect on outcome. The zone of injury, an early mobilisation programme or concurrent injury to the digital nerve had no significant effect on the final result.
Failure analysis enhancement by evaluating the Thermal Laser Stimulation impact on analog ICs (2008)

Technology advances in mixed-mode and analog ICs, involving multiple functions inside the device, make Failure Analysis (FA) difficult. Variation Mapping techniques based on Thermal Laser Stimulation (TLS [1],[2],[3]) have already proven their efficiency for the localization of a physical defect or design weakness. Their extension will play a key FA role but the impact of IR laser beam on the basic analog structures has to be better understood. In this paper we will make this necessary study based on simulations & experimentations. The results allow a better understanding of device activities under TLS to, finally, improve the failure localization process.
Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes (2020)

(Cell Reports 21, 3700–3707; December 26, 2017) In the originally published version of this article, in the legend to Figure S1 (which relates to main Figure 1C), the definition of TERT status in cell lines as “wt, wild type promoter with biallelic expression” should instead be “wt, wild type promoter; some of these are BAE (N = 43; Huang et al., 2015) and some are undetermined.” This correction does not change any of the stated conclusions of our paper but is reported here so that others using these cell lines will not be misled. The authors regret this error. Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT GenesStern et al.Cell ReportsDecember 26, 2017In BriefThe promoter for a telomerase gene (TERT) is the third most frequently mutated site in cancer. These mutations drive unusual expression of TERT from a single allele, allowing unceasing cell division. Stern et al. identify modifications of the promoter that appear to collaborate to maintain this expression pattern in these cancers. Full-Text PDF Open Access
<title>Splitting a colon geometry with multiplanar clipping</title> (1998)

Virtual colonoscopy, a recent three-dimensional (3D) visualization technique, has provided radiologists with a unique diagnostic tool. Using this technique, a radiologist can examine the internal morphology of a patient's colon by navigating through a surface-rendered model that is constructed from helical computed tomography image data. Virtual colonoscopy can be used to detect early forms of colon cancer in a way that is less invasive and expensive compared to conventional endoscopy. However, the common approach of 'flying' through the colon lumen to visually search for polyps is tedious and time-consuming, especially when a radiologist loses his or her orientation within the colon. Furthermore, a radiologist's field of view is often limited by the 3D camera position located inside the colon lumen. We have developed a new technique, called multi-planar geometry clipping, that addresses these problems. Our algorithm divides a complex colon anatomy into several smaller segments, and then splits each of these segments in half for display on a static medium. Multi-planar geometry clipping eliminates virtual colonoscopy's dependence upon expensive, real-time graphics workstations by enabling radiologists to globally inspect the entire internal surface of the colon from a single viewpoint.
Health Security Preparedness and Industry Trends (2015)

Given the number and diversity of risks in today's complex society, it is essential to focus on global risks that can be reduced through affordable, feasible approaches. Thus, the risks that should command the greatest focus are emergent infectious diseases. Fortunately, preparing responses to such threats can be entirely agnostic as to source or intent of the threat. This article considers the emergent infectious clinical threats, characterizes the steps that are essential to take to prepare for such threats, and discusses the roles that the biomedical industry should play in both the preparation for and response to such threats. The author assesses the readiness of the industry to play its role and suggests steps to consider to enable a more robust response.
A Conceptual and Experimental Exploration of Electrovibration on the Palm and the Body (2022)

We present an exploration of electrovibration beyond the fingertip. We first explored the design space and feasibility of electrovibrating clothing and wearables, before pivoting to its use on rigid objects that our palms frequently brush against. We then conceptualized and sketched an electro-vibrating keyboard that produces tactile feedback on the palms. To better understand the capabilities of this keyboard, we then conducted a psychophysical experiment with 14 participants to measure the detection thresholds of electrovibration at the palm and the fingertip. We found no statistically significant difference between the palm and fingertip, which suggests that the palm is an appropriate target for electrovibration.
Stability of MMF transmission characteristics with wide variety of laser linewidth (2022)

In this study, we evaluated the relationship between the time variability of the transmission characteristics of multimode fiber (MMF) and laser linewidth. By varying the laser linewidth from 0.1kHz to 1.89THz, it is possible to grasp the tendency over a wide range, from narrow to ultra-wide linewidth. We were able to confirm that the time-varying characteristics of the frequency characteristics, which affect the MMF transmission characteristics, depend on the laser linewidth and time variability decreases with an increasing laser linewidth.
Supplementary Tables from The Magnitude of Androgen Receptor Positivity in Breast Cancer Is Critical for Reliable Prediction of Disease Outcome (2023)

&lt;p&gt;Supplementary Tables&lt;/p&gt;
Isolation and characterization of a novel Wolbachia bacteriophage from Allonemobius socius crickets in Missouri (2021)

Abstract Wolbachia are endosymbionts of numerous arthropod and some nematode species, are important for their development and if present can cause distinct phenotypes of their hosts. Prophage DNA has been frequently detected in Wolbachia , but particles of Wolbachia bacteriophages (phage WO) have been only occasionally isolated. Here, we report the characterization and isolation of a phage WO of the southern ground cricket, Allonemobius socius , and provided the first whole-genome sequence of phage WO from this arthropod family outside of Asia. We screened A. socius abdomen DNA extracts from a cricket population in eastern Missouri by quantitative PCR for Wolbachia surface protein and phage WO capsid protein and found a prevalence of 55% and 50%, respectively, with many crickets positive for both. Immunohistochemistry using antibodies against Wolbachia surface protein showed many Wolbachia clusters in the reproductive system of female crickets. Whole-genome sequencing using Oxford Nanopore MinION and Illumina technology allowed for the assembly of a high-quality, 55 kb phage genome containing 63 open reading frames (ORF) encoding for phage WO structural proteins and host lysis and transcriptional manipulation. Taxonomically important regions of the assembled phage genome were validated by Sanger sequencing of PCR amplicons. Analysis of the nucleotides sequences of the ORFs encoding the large terminase subunit (ORF2) and minor capsid (ORF7) frequently used for phage WO phylogenetics showed highest homology to phage WOKue of the Mediterranean flour moth Ephestia kuehniella (94.18% identity) and WOLig of the coronet moth, Craniophora ligustri (96.86% identity), respectively. Transmission electron microscopy examination of cricket ovaries showed a high density of phage particles within Wolbachia cells. Isolation of phage WO revealed particles characterized by 40-62 nm diameter heads and up to 190 nm long tails. This study provides the first detailed description and genomic characterization of phage WO from North America that is easily accessible in a widely distributed cricket species.
Effect of Decursin on the Expression of β-Catenin and Matrix Metalloproteinase-7 in Prostate Cancer Cell Lines (2009)

Purpose: Alterations in the Wnt/β-catenin pathway are associated with the development and progression of human prostate cancer. Decursin can attenuate the Wnt/β-catenin pathway. We investigated the relationship between the Wnt/β-catenin pathway and decursin in prostate cancer cells. Materials and Methods: PC-3 and LNCaP cell lines were used. Cell viability was measured with methyl-thiazole tetrazolium bromide (MTT) assays, and cell apoptosis analysis was performed by FACScan. The amount of β-catenin protein after treatment with decursin was measured by Western blot analysis. Expression of MMP-7 mRNA was detected by real-time polymerase chain reaction (RT-PCR). Results: Death and apoptosis were increased after treatment with decursin 0.5-100μM in PC-3 and LNCaP cells. This was revealed dose and time-dependent increase of cancer cell death on 24, 48 and 72 hours. FACScan showed an increment of apoptosis on 24, 48 hours. Expression of intracellular β-catenin protein was decreased dose-dependently in both of prostate cancer cell lines. Decursin reduced MMP-7 mRNA expression on 6, 12, 24, 48 hours dose-dependently. Conclusions: Decursin affects the viability of prostate cancer cells. Increased cancer cell death was associated with increased apoptosis. This study suggests that decursin may play a role in the treatment of prostate cancer. (Korean J Urol 2009;50:81-88)
A Simple Method for Evaluating Within Sample Prognostic Balance Achieved by Published Comorbidity Summary Measures (2014)

Examination of survival curves within strata defined by a comorbidity summary measure can be a useful tool for determining whether a published method appropriately accounts for comorbidities. A comorbidity score is only as good as those variables included.
Synthesis and electroluminescence properties of fluorene containing arylamine oligomer (2004)

Abstract We synthesized a blue fluorescent fluorene containing arylamine oligomer, bis(9,9,9′,9′‐tetra‐ n ‐octyl‐2,2′‐difluorenyl‐7‐yl)phenylamine (DFPA), and investigated its electroluminescence (EL) properties. Organic EL devices with a structure of glass/indium‐tin oxide/acid‐doped poly(thiophene) derivative/DFPA/aluminum complex (BAlq)/cesium‐doped macrocyclic compound/Al were fabricated. The device exhibited blue emission, peaking at 432 nm, from the DFPA layer. The maximum luminance of 1800 cd/m 2 and an external quantum efficiency of 1.5% were observed. Copyright © 2004 John Wiley &amp; Sons, Ltd.
Time-frequency test signal synthesis for acoustic measurements during music concerts. (2009)

When occupied by an audience, a musical performance space exhibits different acoustic characteristics compared to when it is empty. To obtain acoustical measurements with an audience present would require them to sit through an entire session of acoustic test signals, which is not practical. The dynamics of room acoustics parameters during an on-going concert may also be important to the mixing and recording engineers. These acoustic measurement scenarios demand an analysis tool for performing the designated tests during music concert sessions while not being noticeable by the audience. An acoustic measurement technique employing test signals generated during a musical performance is proposed. This method employs an adaptive time-frequency synthesis algorithm that determines the energy vacancies in the spectrogram of the on-going performance and automatically generates low-energy test signals that fill in the vacancies. The energy level of the test signal can be low enough to be masked by the music while high enough to be measurable above the noise floor. Several classes of test signals are proposed and their implementations in live musical events are demonstrated. Different system identification methods for estimating architectural acoustics parameters from the recorded test signals are also discussed and compared.
Olefin Polymerization and Copolymerization with Alkylaluminum-lnitiator Systems. VII. Initiation by Electrophilic Halogens (1973)

Abstract The discovery of initiation of cat ionic polymerization of isobutylene and styrene by electrophilic chlorine generated by the reaction of chlorine and trimethylaluminum in the temperature range -40 to -100° is reported. Bromine and trimethylaluminum is a very poor initiating system, and iodine and trimethylaluminum does not initiate the polymerization of either isobutylene or styrene. Polymerization of isobutylene initiated by chlorine and trimethylaluminum shows a linear plot of log Mv vs 1/T with an overall EDPof ∼1.9 kcal, mole. The molecular weights (Mw) of polystyrene obtained with the Cl2/Me3Al system appear to be the highest ever reported for cationic polymerization of this monomer under comparable conditions. The mechanism of initiation has been investigated by model experiments: The reaction between Cl2/ Me3Al and 2,2,4-trimethyl-l-pentene gave three chlorinated products (2-chloromechyl-4,4-dimethyl-l-pentene, 1-chloro-2,4,4-trimethyl-1-pentene, and 2-chioromethyl-2,4,4-trimethyl-pentane). The position of chlorine in these compounds indicate initiation by electrophilic chlorine, Cl. Some preliminary results obtained using diethylaluminum chloride-halogens as coinitiator-initiator systems are also described.
0.13 μm 210 GHz f/sub T/ SiGe HBTs - expanding the horizons of SiGe BiCMOS (2003)

SiGe BiCMOS is in its fourth lithographic generation since introduction of the 0.5/spl mu/m. The key component is the SiGe-base HBT whose performance (f/sub T/, f/sub MAX/) is improved to >200GHz in the 0.13/spl mu/m generation. Evolution and future directions of SiGe BiCMOS technology and product applications are reviewed.
The NAAG’ing Concerns of Modeling Human Alzheimer’s Disease in Mice (2019)

Studies over the past two decades report significant reductions in brain N-acetylaspartyl glutamate (NAAG) levels in neurodegenerative diseases with associated cognitive impairment, including Alzheimer's disease (AD). Because NAAG is cleaved by glutamate carboxypeptidase II (GCPII), restoration of brain NAAG levels via GCPII inhibition is a potential therapeutic strategy for AD. Herein, studies were conducted to identify an appropriate murine model of AD that recapitulates human brain NAAG changes in order to preclinically evaluate the therapeutic benefit of GCPII inhibition. Our opposing findings of brain NAAG changes in human and mouse AD highlights the limited predictive value of AD mouse models.
Zero Shot Learning with the Isoperimetric Loss (2020)

We introduce the isoperimetric loss as a regularization criterion for learning the map from a visual representation to a semantic embedding, to be used to transfer knowledge to unknown classes in a zero-shot learning setting. We use a pre-trained deep neural network model as a visual representation of image data, a Word2Vec embedding of class labels, and linear maps between the visual and semantic embedding spaces. However, the spaces themselves are not linear, and we postulate the sample embedding to be populated by noisy samples near otherwise smooth manifolds. We exploit the graph structure defined by the sample points to regularize the estimates of the manifolds by inferring the graph connectivity using a generalization of the isoperimetric inequalities from Riemannian geometry to graphs. Surprisingly, this regularization alone, paired with the simplest baseline model, outperforms the state-of-the-art among fully automated methods in zero-shot learning benchmarks such as AwA and CUB. This improvement is achieved solely by learning the structure of the underlying spaces by imposing regularity.
An Intelligent Controller For Special Event Traffic Management (2005)

This paper describes a neural network system developed to adaptively control surface signals to maximize traffic flow. Utilizing a neural network optimization model, the system was created with special emphasis placed upon traffic management during special events in preparation for the 1996 Summer Olympics in Atlanta, Georgia. Results are presented demonstrating the system's ability to manage traffic associated with stadium sporting events.
Measurement of the nuclear modification factor for muons from charm and bottom hadrons in Pb+Pb collisions at 5.02 TeV with the ATLAS detector (2022)

Heavy-flavour hadron production provides information about the transport properties and microscopic structure of the quark–gluon plasma created in ultra-relativistic heavy-ion collisions. A measurement of the muons from semileptonic decays of charm and bottom hadrons produced in Pb+Pb and pp collisions at a nucleon–nucleon centre-of-mass energy of 5.02 TeV with the ATLAS detector at the Large Hadron Collider is presented. The Pb+Pb data were collected in 2015 and 2018 with sampled integrated luminosities of 208μb−1 and 38μb−1, respectively, and pp data with a sampled integrated luminosity of 1.17pb−1 were collected in 2017. Muons from heavy-flavour semileptonic decays are separated from the light-flavour hadronic background using the momentum imbalance between the inner detector and muon spectrometer measurements, and muons originating from charm and bottom decays are further separated via the muon track's transverse impact parameter. Differential yields in Pb+Pb collisions and differential cross sections in pp collisions for such muons are measured as a function of muon transverse momentum from 4 GeV to 30 GeV in the absolute pseudorapidity interval |η|<2. Nuclear modification factors for charm and bottom muons are presented as a function of muon transverse momentum in intervals of Pb+Pb collision centrality. The bottom muon results are the most precise measurement of b quark nuclear modification at low transverse momentum where reconstruction of B hadrons is challenging. The measured nuclear modification factors quantify a significant suppression of the yields of muons from decays of charm and bottom hadrons, with stronger effects for muons from charm hadron decays.
Fast, flexible filtering with phlat (2006)

Systems for fast search of personal information are rapidly becoming ubiquitous. Such systems promise to dramatically improve personal information management, yet most are modeled on Web search in which users know very little about the content that they are searching. We describe the design and deployment of a system called Phlat that optimizes search for personal information with an intuitive interface that merges search and browsing through a variety of associative and contextual cues. In addition, Phlat supports a unified tagging (labeling) scheme for organizing personal content across storage systems (files, email, etc.). The system has been deployed to hundreds of employees within our organization. We report on both quantitative and qualitative aspects of system use. Phlat is available as a free download at http://research.microsoft.com/adapt/phlat.
Gliflumide, a new oral antidiabetic of high potency and efficacy. (1975)

Gliflumide is an optically active sulfonylaminopyrimidine. In rats, the drug exhibited a long-lasting hypoglycemic effect following oral as well as intravenous administration. This effect resembled the action of glibenclamide, but was brought about by doses 5-10 times lower. In healthy volunteers, oral administration (0.0125 mg/kg) or intravenous injection (0.01mg/kg) of gliflumide resulted in a 30-40 per cent decrease of blood glucose characterized by slow onset and long duration. The stimulation of insulin secretion was studied after intravenous injection of gliflumide (0.01 mg/kg) and compared to the action of glibenclamide (0.01 mg/kg) and tolbutamide (10 mg/kg). Although the effect of these doses, measured by the area above the initial level, was similar, a different time course of action was found. Gliflumide and glibenclamide, compared with tolbutamide, produced a delayed and prolonged response. These characteristics were more pronounced with gliflumide. Maximal serum insulin levels were found after 3, 23, and 90 minutes for tolbutamide, glibenclamide, and gliflumide, respectively. In maturity-onset diabetics requiring glibenclamide or glibenclamide + biguanide, gliflumide was shown to have about the same efficacy as glibenclamide, the corresponding doses being 1.5-5 (generally 3) times lower.
Regioisomer effects of dibenzofuran-based bipolar host materials on yellow phosphorescent OLED device performance (2020)

Four regioisomers were synthesized for use as bipolar host materials for phosphorescent organic light-emitting diodes (PhOLEDs) by classic cross-coupling reactions using cyanofluorene and fused dibenzofuran and were readily purified.
Bacterial metatranscriptomes in wastewater can differentiate virally infected human populations (2022)

Abstract Monitoring wastewater samples at building-level resolution screens large populations for SARS-CoV-2, prioritizing testing and isolation efforts. Here we perform untargeted metatranscriptomics on virally-enriched wastewater samples from 10 locations on the UC San Diego campus, demonstrating that resulting bacterial taxonomic and functional profiles discriminate SARS-CoV-2 status even without direct detection of viral transcripts. Our proof-of-principle reveals emergent threats through changes in the human microbiome, suggesting new approaches for untargeted wastewater-based epidemiology.