gebhart/patrepeval huggingface dataset:
A self-aware processor SoC using energy monitors integrated into power converters for self-adaptation (2014)

This paper presents a self-aware processor with energy monitoring circuits that can measure actual energy consumption of the key blocks. The monitors are embedded into on-chip DC/DC converters and generate results within 10% of accuracy with minimal power (<;0.1%) and area (<;1%) overhead. Our system, which is implemented in 0.18μm technology, is designed to be voltage scalable from 1.8V down to 0.6V. Low-voltage SRAM operation is made possible through the use of 8T bit-cells and write-assists. The d-caches are designed to be re-configurable in associativity and size to adapt to compute- versus cache-bound phases of applications. Cache configuration is performed in <; 3 clock cycles including tag invalidation. These hardware features enable a software self-aware computation engine (SEEC) to dynamically adapt the processor to meet performance and energy goals. Measurement results show that up to 8.4× energy savings can be achieved with DVFS and self-adaptation.
Spectroscopy with gas lasers. (1966)

Optical- and IR-maser spectroscopy of inhomogeneously broadened resonances, using gas lasers
Evaluating the Time-Temperature Requirement for <I>E. coli</I> Destruction Using the Live/Dead Test (2010)

Evaluating the Time-Temperature Requirement for E. coli Destruction Using the Live/Dead TestThe EPA provides a time-temperature equation needed to meet class A standards for thermophilic anaerobic digestion, which should be sufficient to lower fecal coliform (FC) levels to below 1000 MPN/g dry solids. However, it has been observed that while FC levels meet those standards after digestion, there can be a sudden increase in FC concentration after centrifuge dewatering. Two sets of...Author(s)Wade YankeyYen-Chih ChenSudhir MurthySourceProceedings of the Water Environment FederationSubjectSession 14: Thermophilic Digestion and Thermal HydrolysisDocument typeConference PaperPublisherWater Environment FederationPrint publication date Jan, 2010ISSN1938-6478SICI1938-6478(20100101)2010:4L.935;1-DOI10.2175/193864710802767425Volume / Issue2010 / 4Content sourceResiduals and Biosolids ConferenceFirst / last page(s)935 - 943Copyright2010Word count233Subject keywordsE. coliVBNCLive/DeadReactivation
Chaire d’Innovation technologique - Liliane Bettencourt (2009)

Mathias Fink a donné sa leçon inaugurale le 12 février 2009. Son cours intitulé « Ondes et Images » a commencé le 2 mars 2009.
Endoscopic ultrasound–guided biopsy for the diagnosis of focal lesions of the spleen (2003)

Needle biopsy of splenic lesions using computed tomography (CT) or ultrasound (US) is difficult if the size of the lesion is small. It may be dangerous if the lesion is adjacent to the splenic hilum or located peripherally. We used endoscopic ultrasound–guided fine needle aspiration (EUS-FNA) to elucidate the tissue diagnosis of splenic abnormalities. EUS-FNA was performed in 12 patients when US- or CT-guided biopsy was inconclusive (n = 5), was not attempted because of small tumor size (0.9–1.4 cm; n = 4), or was considered dangerous (n = 3). A linear echo-endoscope and 22-gauge needles were used for cytology and bacteriology. The age of the patients was 19–68 yr (median 32 yr). Seven patients were male and five female. The size of the lesions was 0.8–4.2 cm (median 1.4 cm). Cytology was inadequate in one patient. Bacteriology was positive for Staphylococcus aureus and Serratia in one patient each, and cultures were positive for Mycobacterium tuberculosis in two patients. A positive diagnosis was made in 10 of 12 patients (83%). Final diagnoses were tuberculosis in two patients, Hodgkin’s disease in two, sarcoidosis in two, abscesses in two, metastatic colon cancer in one, and infarction in one. Suspected recurrence of non-Hodgkin’s lymphoma was not confirmed in one case. One patient experienced pain after puncture, but no hematoma was demonstrated on subsequent US examination. EUS-FNA cytodiagnosis in patients with unknown splenic lesions seems feasible, even in very small foci, when CT- or US-guided biopsy fails. Additional material for bacteriology may show benign treatable diseases such as abscesses or tuberculosis.
ProbeLynx: a tool for updating the association of microarray probes to genes (2004)

As genome sequence data and gene prediction improve, probes developed for a given microarray experiment should be continuously re-evaluated for their specificity for given genes. ProbeLynx(www.pathogenomics.ca/probelynx) is a new web service which uses current genomic sequence information to re-examine microarray probe specificity and provide annotation updates relevant to determining which gene(s) and transcript(s) are associated with a given probe. Probe sequences (either oligonucleotide- or cDNA-based) are uploaded in FASTA format and the results returned as a tab-delimited flat file for insertion into a spreadsheet application or database management system for further analysis. ProbeLynx has been initially developed to focus on arrays derived from human, mouse, chicken and bovine genomes, but may be expanded to handle other genomic datasets. ProbeLynx offers microarray users the important ability to continuously assess the potential of a probe to cross-hybridize to paralogous genes and the suitability of a given probe to investigate a transcript of interest. By also including the latest gene function annotation information in the output, ProbeLynx provides the critical first step in updating microarray data annotation.
No evidence of XMRV in prostate cancer cohorts in the Midwestern United States (2011)

The lack of XMRV sequences or strong anti-XMRV neutralizing antibodies indicates no or very low prevalence of XMRV in our cohorts. We conclude that real-time PCR- and IHC-positive samples were due to laboratory contamination and non-specific immune reactions, respectively.
Cellular Mechanics and Biology of Tumor Cell-Leukocyte Interactions in the Near Wall Region Under Shear Flow Conditions (2007)

Malignant melanoma has a high propensity for metastatic spread, making it the most deadly form of skin cancer. Currently, no effective treatment exists to prevent melanoma metastasis or to inhibit metastatic tumors growing in distant organs [1,2].
Incremental predictive and adaptive noise compensation (2009)

Model compensation schemes are a powerful approach to handling mismatches between training and testing conditions. Normally these schemes are run in a batch adaptation mode, re-recognising the utterance used to estimate the noise model parameters. For many applications this introduces unacceptable latency. This paper examines three forms of incremental mode model-based compensation: vector Taylor series; joint uncertainty decoding; and predictive CMLLR. These predictive schemes can also be combined with adaptive schemes such as CMLLR. By combining the approaches, weaknesses of each can be addressed. The performance is evaluated on in-car recorded data, where the combined incremental scheme shows gains over either individually.
Bioassay Techniques for Drug Development (2001)

The goal of an activity-directed isolation process is to isolate bioactive compounds which may provide structural leads of therapeutic importance. Whereas the traditional process of drug development is long and expensive, simple and rapid bioassays can serve as the starting point for drug discovery. This book presents a range of "bench top" bioassa
TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating the SMAD2/3 transcription factors (2019)

Fibrosis is associated with almost all forms of chronic cardiac and skeletal muscle diseases. The accumulation of extracellular matrix impairs the contractility of muscle cells contributing to organ failure. Transforming growth factor β (TGF-β) plays a pivotal role in fibrosis, activating pro-fibrotic gene programmes via phosphorylation of SMAD2/3 transcription factors. However, the mechanisms that control de-phosphorylation of SMAD2 and SMAD3 (SMAD2/3) have remained poorly characterized. Here, we show that tissue non-specific alkaline phosphatase (TNAP, also known as ALPL) is highly upregulated in hypertrophic hearts and in dystrophic skeletal muscles, and that the abrogation of TGF-β signalling in TNAP-positive cells reduces vascular and interstitial fibrosis. We show that TNAP colocalizes and interacts with SMAD2. The TNAP inhibitor MLS-0038949 increases SMAD2/3 phosphorylation, while TNAP overexpression reduces SMAD2/3 phosphorylation and the expression of downstream fibrotic genes. Overall our data demonstrate that TNAP negatively regulates TGF-β signalling and likely represents a mechanism to limit fibrosis.
John Charnley Award: Randomized Clinical Trial of Direct Anterior and Miniposterior Approach THA: Which Provides Better Functional Recovery? (2018)

Level I, therapeutic study.
Development of an Artificial-Antigen-Presenting-Cell-Based Assay for the Detection of Low-Frequency Virus-Specific CD8+T Cells in Whole Blood, with Application for Measles Virus (2009)

Evaluation of the immune responses induced by childhood vaccines requires measurement of T-cell, as well as antibody, responses. However, cellular immune responses are often not analyzed because of technical hurdles and the volume of blood required. Therefore, a sensitive and specific assay for antigen-specific T cells that utilizes a small volume of blood would facilitate new vaccine evaluation. We developed a novel assay for quantifying virus-specific CD8(+) T cells that combines the use of HLA-A2 immunoglobulin-based artificial antigen-presenting cells (aAPCs) for stimulation of antigen-specific CD8(+) T cells in whole blood with quantitative real-time reverse transcription-PCR (qRT-PCR) to detect gamma interferon (IFN-gamma) mRNA. This assay was optimized using a well-established cytomegalovirus (CMV) CD8(+) T-cell system. The aAPC-qRT-PCR assay had comparable sensitivity to intracellular cytokine staining (ICS) in detecting CMV-specific CD8(+) T cells with a detection limit of less than 0.004%. The assay was applied to the detection of low-frequency measles virus (MV)-specific CD8(+) T cells by stimulating blood from five MV-immune HLA-A*0201 donors with four different MV-specific peptides (MV peptide aAPCs). Stimulation with three of the MV peptide aAPCs resulted in significant increases in IFN-gamma mRNA ranging from 3.3- to 13.5-fold. Our results show that the aAPC-qRT-PCR assay is highly sensitive and specific and can be standardized for screening MV-specific CD8(+) T cells in vaccine trials. The technology should be transferable to analysis of CD8(+) T-cell responses to other antigens.
Beyond Open Source: The TouchDevelop Cloud-based Integrated Development and Runtime Environment (2014)

The creation and maintenance of mobile applications is a complex process, involving a set of technologies ranging from an application programming language and integrated devel-opment environment (IDE), through the deployment and update models of the various app stores, to a cloud back end that stores user and telemetry data (with its own pro-gramming language and a variety of hosting issues). We present the design of a Cloud-based Integrated Devel-opment and Runtime Environment (CIDRE) to make the creation of mobile+cloud applications easier for non-expert programmers. A CIDRE combines an online programmer community, a browser-based IDE, and an app store. The deep integration of the three elements decreases friction in the software engineering of apps through automated source control and dependency management, an open architecture for distributed plugins, and a crowd-sourced collection of crash reports and coverage/profile data. A CIDRE brings together three audiences: language/IDE designers (the au-thors of this paper), application programmers, and applica-tion users, who can easily modify the apps they are using (all distributed in source), and become programmers them-selves. We have implemented a CIDRE in the form of TouchDeve-lop, a streamlined, cross-platform, browser-based program-ming environment. We describe the design of TouchDevelop and the use of automation at various points to make it easy for the three parties to communicate and give feedback to one another. As we will show through our analysis of three years of deployment of TouchDevelop to hundreds of thou-sands of users, much of the design of our CIDRE can inform other approaches to cloud-based software engineering.
ChemInform Abstract: Towards the Total Synthesis of Saponaceolides: Synthesis of cis‐2,4‐Disubstituted 3,3‐Dimethylmethylenecyclohexanes. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Direct Air Capture of CO2 with Chemicals: A Technology Assessment for the APS Panel on Public Affairs (2011)

LSMO
Disruption of the CD Loop by Enzymatic Cleavage Promotes the Formation of Toxic Transthyretin Oligomers through a Common Transthyretin Misfolding Pathway (2020)

Amyloid formation of full-length TTR involves dissociation of the native tetramers into misfolded monomers that self-assemble into amyloid. In addition to the full-length TTR, C-terminal fragments including residues 49-127 were also observed <i>in vivo</i>, implying the presence of additional misfolding pathways. It was previously proposed that a proteolytic cleavage might lead to the formation of the C-terminal fragment TTR amyloid. Here, we report mechanistic studies of misfolding and aggregation of a TTR variant (G53A) in the absence and presence of a serine protease. A proteolytic cleavage of G53A in the CD loop (K48 and T49) with agitation promoted TTR misfolding and aggregation, suggesting that the proteolytic cleavage may lead to the aggregation of the C-terminal fragment (residues 49-127). To gain more detailed insights into TTR misfolding promoted by proteolytic cleavage, we investigated structural changes in G53A TTR in the presence and absence of trypsin. Our combined biophysical analyses revealed that the proteolytic cleavage accelerated the formation of spherical small oligomers, which exhibited cytotoxic activities. However, the truncated TTR appeared to maintain native-like structures, rather than the C-terminal fragment (residues 49-127) being released and unfolded from the native state. In addition, our solid-state nuclear magnetic resonance and Fourier transform infrared structural studies showed that the two aggregates derived from the full-length and cleaved TTR exhibited nearly identical molecular structural features, suggesting that the proteolytic cleavage in the CD loop destabilizes the native tetrameric structure and accelerates oligomer formation through a common TTR misfolding and aggregation mechanism rather than through a distinct molecular mechanism.
An Efficient Low-Magnetic-Field-Operation Superradiant Relativistic Backward-Wave Oscillator With Front Extraction Structure (2023)

An <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${X}$ </tex-math></inline-formula> -band superradiant relativistic backward-wave oscillator (RBWO) operating at a low magnetic field with power conversion efficiency exceeding unity is proposed. The device efficiency is improved from two aspects: beam transmission stability focused by a low guiding magnetic field and microwave transmission efficiency. First, a gradually decaying axial magnetic field is applied. It could not only suppress the initial radial oscillation amplitude of the electron beam envelope but also transform the high transverse momentum of electrons into the axial momentum, which is beneficial to the beam–wave interaction. Second, a novel structure with a front extractor is introduced. The backward wave is extracted into a coaxial channel outside the slow wave structure (SWS) and transmitted in TEM mode to avoid the power loss of the reflected microwave in the SWS caused by the dispersion effects. Particle-in-cell (PIC) simulation results reveal that when the intense relativistic electron beam (IREB) propagating in a 36-period superradiance-RBWO (SR-RBWO) is confined with a magnetic induction intensity that decreases from 0.81 T in cathode region to 0.43 T in interaction region, the output power of 1.04 GW corresponding to conversion factor <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${K}$ </tex-math></inline-formula> = 1.55 can be obtained. The merits of low-magnetic-field operation and high efficiency make this tube a promising device used for the miniaturization of high-power SR systems.
Experimental Evaluation of Starved AP Identification and Management Schemes in Mobile Cooperative WLAN System toward 5G (2018)

Throughput starvation, which occurs due to the well-known exposed/hidden terminal problem in CSMA/CA based channel access mechanisms, will be a critical problem for dense wireless LAN systems. To address this problem, we previously proposed schemes that identify and manage starved devices by monitoring the beacon signals transmitted by access points (APs) and showed that they can identify low throughput devices and have potential to improve WLAN system throughput. This paper describes experimental results obtained for schemes that identify starved APs and manage their channels. Numerous experiments verified that the schemes can identify APs that have quite low throughput as starved APs and that management can reduce the low throughput APs in real environments. We also indicate that it is necessary to consider beacon transmission delay fluctuation when determining the threshold used for identifying starved APs in cases such as the surrounding environment fluctuating in a short period.
Bitwidth-Optimized Energy-Efficient FFT Design via Scaling Information Propagation (2021)

The Fast Fourier Transform (FFT) is an efficient algorithm widely used in digital signal processing to transform between the time domain and the frequency domain. For fixed-point VLSI implementations, dynamic range growth inevitably occurs at each stage of the FFT operation. However, current methods either waste bitwidth or consume excessive resources when dealing with the dynamic range growth issue. To address this issue, we propose an efficient scaling method called Scaling Information Propagation (SIP) to alleviate the problem of dynamic range growth, which makes full use of bitwidth with much less extra area consumed than the state-of-the-art solutions. In two consecutive transform operations, the SIP method extracts scaling information and makes scaling decisions in the former transform, then executes those in the latter one. We implement the FFT’s VLSI architecture in the orthogonal frequency division multiplexing (OFDM) and the holographic video compression (HVC) systems to verify the SIP method. Compared to the state-of-the-art, experimental results after VLSI synthesis show that our method achieves 9.38% energy reduction and 8.36% area savings when requiring 1.02 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-7</sup> bit error ratio (BER) of the OFDM system, and 33.47% energy reduction and 30.98% area savings when requiring 20dB signal-to-noise ratio (SNR) of the HVC system, respectively.
Cupric Ion Species in Cu(II)-Exchanged K−Offretite Gallosilicate Determined by Electron Spin Resonance and Electron Spin Echo Modulation Spectroscopies (1996)

The location of Cu(II) and its interaction with deuterated adsorbates in Cu(II)-exchanged gallosilicate with the offretite channel-type structure were investigated by electron spin resonance (ESR) and electron spin echo modulation (ESEM) spectroscopies. It is suggested that in fresh, hydrated offretite gallosilicate Cu(II) is in the main channel coordinated to three water molecules and three framework oxygens in a six-ring window of an ε-cage to form distorted octahedral coordination. Upon evacuation at increasing temperature, Cu(II) moves from the main channel through an ε-cage to a hexagonal prism. Dehydration at 400 °C produces one Cu(II) species located in a recessed site in a hexagonal prism based on a lack of broadening of its ESR lines by oxygen. Adsorption of polar molecules such as water, alcohols, dimethyl sulfoxide, and ammonia causes changes in the ESR spectrum of the Cu(II), indicating migration into cation positions in the main channels where adsorbate coordination can occur. However, nonpolar ethylene does not cause migration of Cu(II). Cu(II) forms complexes with two molecules of methanol, ethanol, and propanol and one molecule of dimethyl sulfoxide based on ESEM data. Cu(II) is suggested to form a trigonal-bipyramidal complex with two ammonias in axial positions and three framework oxygens in a six-ring window of an ε-cage based on its ESR parameters and ESEM data.
Adrenomedullin and Calcitonin Gene-Related Peptide (CGRP) Interact with a Common Receptor of the CGRP1 Subtype in the Human Adrenal Zona Glomerulosa (1999)

Frozen sections of normal adrenal glands, obtained from patients undergoing unilateral nephrectomy for kidney cancer, were labeled in vitro with human [125I]ADM(1-52). Autoradiography showed the presence of abundant ADM binding sites in the zona glomerulosa (ZG) and the outermost portion of the zona fasciculata, which were completely displaced by the addition of an excess of cold ADM(1-52). Calcitonin gene-related peptide (CGRP) and the non-selective ligand of the CGRP-receptor subtypes 1 and 2 CGRP(8-37) eliminated [125I]ADM(1-52) binding in the ZG, while the selective ligand of CGRP receptor subtype 2 [Cys(acm)2,7]-CGRP and CGRP(1-8) were ineffective. These findings confirm the presence of ADM binding sites in the human ZG, and provide the first morphological evidence that ADM and CGRP interact with a common receptor of the CGRP1 subtype.
Time-Domain FPGA Power Delivery Network Characterization Methodology (2021)

Designing power distribution or delivery networks (PDNs) for field-programmable gate arrays (FPGAs) has become increasingly challenging. This makes PDN technology look-ahead prior to product design cycle extremely crucial in helping modern FPGAs to cope with rapidly-increasing power delivery challenges.
Advancing Nerve Regeneration: Translational Perspectives of Tacrolimus (FK506) (2023)

Peripheral nerve injuries have far-reaching implications for individuals and society, leading to functional impairments, prolonged rehabilitation, and substantial socioeconomic burdens. Tacrolimus, a potent immunosuppressive drug known for its neuroregenerative properties, has emerged in experimental studies as a promising candidate to accelerate nerve fiber regeneration. This review investigates the therapeutic potential of tacrolimus by exploring the postulated mechanisms of action in relation to biological barriers to nerve injury recovery. By mapping both the preclinical and clinical evidence, the benefits and drawbacks of systemic tacrolimus administration and novel delivery systems for localized tacrolimus delivery after nerve injury are elucidated. Through synthesizing the current evidence, identifying practical barriers for clinical translation, and discussing potential strategies to overcome the translational gap, this review provides insights into the translational perspectives of tacrolimus as an adjunct therapy for nerve regeneration.
Supplementary Figure S4 from PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition (2023)

&lt;p&gt;Supplementary Figure S4. DHODH is a target of sensitivity in PTEN deficient cells.&lt;/p&gt;