gebhart/patrepeval huggingface dataset:
Development of a MALDI-TOF MS-based screening panel for accelerated differential detection of carbapenemases in Enterobacterales using the direct-on-target microdroplet growth assay (2020)

Carbapenemase-producing bacteria are a growing issue worldwide. Most phenotypic detection methods are culture-based, requiring long incubation times. We present a phenotypic screening panel for detection of carbapenem non-susceptibility and differentiation of carbapenemase classes and AmpC, the MALDI-TOF MS-based direct-on-target microdroplet growth assay (DOT-MGA). It was validated on 7 reference strains and 20 challenge Enterobacterales isolates. Broth microdilution (BMD) and combination disk test (CDT) were also performed, as well as PCR as reference method. The panel based on the synergy between meropenem and carbapenemase inhibitors, determined by incubating these substances with bacterial suspension on a MALDI-TOF MS target and subsequently assessing bacterial growth on the target's spots by MS. After 4 hours of incubation, DOT-MGA correctly identified KPC, MBL and OXA (100% agreement with PCR). Detection of AmpC coincided with BMD and CDT but agreement with PCR was low, not ruling out false negative PCR results. DOT-MGA delivered more accurate results than BMD and CDT in a significantly shorter time, allowing for detection of carbapenem non-susceptibility, MIC determination and carbapenemase differentiation in one step.
Posterior atlantoaxial facet screw fixation (1993)

Eighteen patients with atlantoaxial instability were treated with posterior atlantoaxial facet screws to obtain immediate rigid fixation of C1-2. Of these 18 patients, instability occurred due to trauma in nine, rheumatoid arthritis in six, neoplasms in two, and os odontoideum in one. Four patients presented with nonunion after failed C1-2 wire and graft procedures. In all cases in this series the screw fixations were augmented with an interspinous C1-2 strut graft which was wired in place to provide three-point stabilization and to facilitate bone fusion. In every case fixation was satisfactory, and C1-2 alignment and stability were restored without complications due to instrumentation. One patient died 3 months postoperatively from metastatic tumor; the spinal fixation was intact. All 17 surviving patients have developed osseous unions (mean follow-up period 12 months, range 6 to 16 months). Posterior atlantoaxial facet screw fixation provides immediate multidirectional rigid fixation of C1-2 that is mechanically superior to wiring or clamp fixation. This technique maximizes success without the need for a supplemental rigid external orthosis, and is particularly useful for pseudoarthrosis.
Hydrogensulfate and tetrakis(hydrogensulfato)borate ionic liquids: synthesis and catalytic application in highly Brønsted-acidic systems for Friedel–Crafts alkylation (2002)

Hydrogensulfate and tetrakis(hydrogensulfato)borate ionic liquids have been synthesised and characterised. These ionic liquids are halogen-free, available from cheap raw materials and easy to prepare. They have been used as additives to sulfuric acid in the Friedel–Crafts-alkylation of benzene with 1-decene. The results clearly demonstrate an interplay of acidity and solubility effects caused by the ionic liquid additive. In some cases, low amounts of ionic liquid additive result in a dramatic improvement of product yield.
Generalized source integral equation (2017)

The Generalized Source Integral Equations (GSIE) is a family of integral formulations which are designed to be inherently compressible, for the purpose of designing general fast direct solvers. These formulations employ highly directional sources with complex radiation patterns rather than the conventional non-directional sources. In this work we employ shielded sources to achieve the desired directivity. Such sources inherently eliminate line-of-sight interactions, thus effectively reducing the problem's dimensionality. The dimensionality reduction leads in turn to O(N log N) complexity for essentially convex two dimensional problems.
Intermediate to Long-Term Follow-up of Cementing Liners into Well-Fixed Acetabular Components (2020)

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Memory-universal prediction of stationary random processes (1998)

We consider the problem of one-step-ahead prediction of a real-valued, stationary, strongly mixing random process (Xi)/sub i=-/spl infin///sup /spl infin//. The best mean-square predictor of X/sub 0/ is its conditional mean given the entire infinite past (X/sub i/)/sub i=-/spl infin///sup -1/. Given a sequence of observations X/sub 1/, X/sub 2/, X/sub N/, we propose estimators for the conditional mean based on sequences of parametric models of increasing memory and of increasing dimension, for example, neural networks and Legendre polynomials. The proposed estimators select both the model memory and the model dimension, in a data-driven fashion, by minimizing certain complexity regularized least squares criteria. When the underlying predictor function has a finite memory, we establish that the proposed estimators are memory-universal: the proposed estimators, which do not know the true memory, deliver the same statistical performance (rates of integrated mean-squared error) as that delivered by estimators that know the true memory. Furthermore, when the underlying predictor function does not have a finite memory, we establish that the estimator based on Legendre polynomials is consistent.
Synthesis and acaricidal activity of 4-pyrimidinyloxy- and 4-pyrimidinylaminoethylphenyl dioxolanes and oxime ethers (2000)

Novel types of mitochondrial respiration inhibitors at complex I, with emphasis on acaricidal activity, have been designed and prepared. The synthetic approach to these 4-pyrimidinylphenyl ethyl ethers and amines with a specific ketal or oxime function in the phenyl side chain is outlined. Bioassays demonstrate their high potential against important spider mites, like Tetranychus urticae and Panonychus ulmi. Structure–activity relationship studies and several biological parameters are discussed. © 2000 Society of Chemical Industry
Plans for conversion of SURF II to SURF III (abstract) (1996)

The Synchrotron Ultraviolet Radiation Facility (SURF II) at the National Institute of Standards and Technology, Gaithersburg, MD, USA, has served as a primary radiometric standard in the vacuum ultraviolet region since its conversion from a synchrotron to an electron storage ring in 1974. The magnet iron, however, dates back to an original betatron design of the late 1940s. The advent of both modern materials and methods of finite element analysis have made possible the design of magnets offering far greater dc performance than the existing SURF system. In this paper we discuss the general design and plans to convert SURF II to SURF III, which will offer reduced radiometric uncertainty, an increase in energy from 300 MeV to 385 MeV, a modernized control system, and two new beamlines, which are not presently possible. Anticipated new beamline activities include a substantial new effort devoted to radiometric improvements from IR to far UV and development of stations for microspectoscopy and electroreflectance.
Asymmetric induction in nitrile oxide cycloadditions to optically active acrylates. Comparisons of acrylate conformations in thermal and acid-catalyzed 1,3-dipolar and Diels-Alder cycloaddition transition states (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric induction in nitrile oxide cycloadditions to optically active acrylates. Comparisons of acrylate conformations in thermal and acid-catalyzed 1,3-dipolar and Diels-Alder cycloaddition transition statesDennis P. Curran, Byeang Hyean Kim, H. P. Piyasena, R. J. Loncharich, and K. N. HoukCite this: J. Org. Chem. 1987, 52, 11, 2137–2141Publication Date (Print):May 1, 1987Publication History Published online1 May 2002Published inissue 1 May 1987https://pubs.acs.org/doi/10.1021/jo00387a004https://doi.org/10.1021/jo00387a004research-articleACS PublicationsRequest reuse permissionsArticle Views436Altmetric-Citations78LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Identification of a /sa/-/sta/ continuum by normally developing and language-delayed children (1978)

Previous studies have demonstrated that language-delayed children as a group are impaired in processing nonverbal and verbal auditory stimuli that change rapidly over time, but in processing similar stimuli that change more slowly [P. Tallal and M. Piercy, Neuropsychol. 13, 69–74, (1975)]. In the present study, 36 language-delayed children and 36 controls were presented with tokens from a /sa/—/sta/ continuum. The syllables were synthesized to differ only in the duration of silence between the offset of frication and the onset of vowel formants which ranged from 0 ms in /sa/ to 100 ms in /sta/. A nonverbal target identification procedure was used in obtaining responses. The language-delayed children were unimpaired on the two end points of the continuum. However, they were either inconsistent in their responses to the entire continuum or required a significantly longer silent period than the normals to identify a syllable as /sta/, as evidenced by a shift in the crossover point on their phoneme boundary functions. Mechanisms which might account for the temporal processing difficulties of language-delayed children and their relation to the language disorder will be discussed. [Work supported by NINCDS.]
Familial Pancreatic Cancer (2009)

Even in the absence of predictive genetic testing, the collection of a careful, detailed family history is an important step in the management of all patients with pancreatic cancer. While most pancreatic cancers that arise in patients with a family history are ductal adenocarcinomas, certain subtypes of pancreatic cancer have been associated with familial syndromes. Therefore, the histologic appearance of the pancreatic cancer itself, and/or the presence and appearance of precancerous changes in the pancreas, may increase the clinical index of suspicion for a genetic syndrome.
Investigation of the output droop characteristics of parallel-connnected DC-DC converters (2002)

The analytical proof that output voltage droop characteristics of parallel-connected DC-DC power converters are only appropriate for very limited applications is presented. Because the converters are rarely made to be identical, near-uniform current-sharing without additional control can be achieved only when converters connected in parallel have similar characteristics of being very close to the ideal current sources. This can occur at a cost of poor voltage regulation. As an alternative, the current-sharing control technique, which requires no remote-sensing, is proposed. The technique ensures uniform or designated current distribution throughout the specified load range. A control circuit module is independently implemented without any preliminary knowledge or any circuit modification of the source converters.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Induction of AKT phosphorylation by a small molecule AKT inhibitor (2005)

Proc Amer Assoc Cancer Res, Volume 46, 2005

5476 

AKT (PKB) is a serine/threonine that plays an important role in apoptosis, cell proliferation and survival. The AKT gene has been amplified in a number of human cancers. Furthermore, AKT activity is elevated in cells with a mutated PTEN tumor suppressor gene. These studies establish AKT as an attractive target for cancer therapy. We have identified a small molecule that specifically inhibits AKT1 with an IC50 of < 1 nM. When MiaPaCa cells (PTEN+) were treated with the inhibitor for 2h, AKT phosphorylation (at 473 site) was induced in a dose dependent manner. This induction was observed as early as 15 min with 1 μM compound treatment. AKT phosphorylation induction was seen in several cancer cell lines. In PTEN (-) cells such as PC3, there was an additional increase in AKT phosphorylation after treatment by the inhibitor. To examine the mechanim(s) for the induction of AKT phosphroylation, we employed LY294002, a PI3-kinase inhibitor. Pre-incubation of MiaPaCa cells with Ly294002 at 50 μM completely inhibited the AKT phosphorylation induction. Our results suggest that the PI3-kinase pathway is involved in the drug-related induction of AKT phosphorylation. Furthermore, there may be a feed-back mechanism involved in the up-regulation of phosphorylation in response to AKT inhibition.
Evaluation Method for Automotive Stereo-Vision Systems (2007)

Safe vehicle guidance under human or computer control requires a thorough understanding of the traversed environment. Consequently if perception systems are to be introduced into mass market vehicles as part of driving assistance systems, their proper operation throughout the vehicle working life is needed. Onboard stereo-vision systems can provide rich information in terms of range, feature recognition, etc., hence the interest by car OEMs. System performance depends on multiple factors like light conditions, algorithms and the mechanical apparatus. Due to inaccuracies produced by changes in the system physical properties due to vibrations, misalignment of fixtures, etc. through the vehicle operational life a reduction in performance will occur. In this paper, an evaluation framework to estimate the performance of a vehicle onboard stereo-vision system in terms of 3D measurements and re-projection errors is presented. The approach considers changes that might occur in the system during the vehicle working life. It includes means to evaluate the self-calibration process often used to correct the effects of physical changes in the stereo-vision system. The results provide key information for the design and geometrical specification of automotive stereo-vision systems. As the potential physical changes in the geometric configuration of the camera-pair over the vehicle life time are difficult to predict, it was necessary to simulate them to generate families of errors that these might trigger on the system performance. The results of the observations and analysis are included; these should assit designers to define the constraints that needed for the layout of cameras as part of the design process.
Hybrid silicon optical gate for packet networks (2013)

We report a hybrid silicon optical gate based on a silicon waveguide with a III–V gain medium and two vertical grating couplers. The gate shows a wide optical bandwidth, high extinction ratio with low internal noise factor and low insertion loss. We further study the gate performance under packet-switched operation.
Real Time Implementation and Experiments of Multi-channel Active Noise Control System for ICU (2021)

The purpose of this study is to help reduce high noise levels experienced by patients in intensive care unit (ICU) environments. The study has designed and developed the active noise control (ANC) system based on filtered x least mean square (FxLMS) to reduce the interfering noise around ICU patients' beds. A multi-channel feed-forward ANC algorithm has been implemented in a real-time digital signal processing system based on TMS320 DSP C6713. This noise cancellation system has been tested in a patient bed with recorded real ICU noise as the noise source to mimic the ICU noisy environment. The experiment setup has been presented. The real-time experiment results show that ANC is a promising solution to solve high noise level problem inside ICU.
Radioligand binding and immunoautoradiographic evidence for a lack of toxicity to dopaminergic nerve terminals in human cocaine overdose victims (1997)

Radioligand binding to and immunolabeling of transport sites associated with monoamine-containing synaptic vesicles affords a novel approach for mapping the integrity of dopaminergic (DAergic) nerve terminals. The present study used [125I]iodovinyltetrabenazine ([125I]TBZ) and a fusion protein antibody directed at the large intraluminal loop of the neuronal vesicular monoamine transporter (hVMAT2-loop) as probes to assess the effects of chronic cocaine use on the integrity of DAergic nerve terminals in the striatum of cocaine fatalities. Visualization of [125I]TBZ binding in human brain revealed a distinct pattern of labeling throughout the rostral-caudal extent of the striatum. Saturation binding of [125I]TBZ in striatal membranes demonstrated a single high affinity site (Kd = 2.3 +/- 0.9 nM and Bmax = 55.5 +/- 8.1 pmol/g tissue) with a pharmacological profile (tetrabenazine > or = iodovinyltetrabenazine > ketanserin > or = reserpine > haloperidol > GBR 12909) consistent with the specific labeling of hVMAT2. Quantitative in vitro autoradiography demonstrated no significant alteration in the density of [125I]TBZ binding sites in the anterior and posterior sectors of the striatum in cocaine fatalities with and without preterminal excited delirium as compared to drug-free and age-matched control subjects. Similarly, the levels of hVMAT2-loop immunoreactivity were not significantly different across control and cocaine fatality groups. The results demonstrate the lack of an alteration in [125I]TBZ binding sites and hVMAT2 protein in the striatum from a young cohort of cocaine fatalities. Since striatal VMAT2 is primarily associated with DAergic nerve terminals, these results suggest that chronic cocaine use failed to affect the integrity of striatal DAergic nerve terminals.
Adaptively and Unconditionally Secure Conversion Protocols between Ramp and Linear Secret Sharing (2015)

Secret sharing (SS) has been extensively studied as for both secure data storage and a fundamental building block for multiparty computation (MPC). Recently, Kikuchi et al. proposed a passively and unconditionally secure conversion protocol that converts from a share of a ramp scheme to another of homomorphic SS scheme. The share-size of the ramp scheme is small, and the homomorphic SS scheme is a class of SS schemes that includes Shamir's and replicated SS schemes, which are convenient for MPC. Therefore, their protocol is a conversion from an SS scheme whose share-size is small to MPC-friendly SS schemes, and can be applied to reduce the amount of data storage while maintaining extendibility to MPC. We propose five unconditionally and actively secure protocols in the honest majority. In this paper, we consider a privacy and correctness as security requirement and does not consider a robustness: A cheat caused by an active adversary must be detected. These protocols consist of two conversion protocols, two reveal protocols and a protocol generating specific randomness. Main protocols among them are two conversion protocols for bilateral conversion between a ramp scheme and linear SS scheme, and the others are building blocks of the main protocols. Linear SS scheme is a subset of homomorphic SS scheme but includes both Shamir's and replicated SS schemes. Therefore, these main protocols are conversions between an SS scheme whose share-size is small to MPC-friendly SS schemes. These main protocols are unconditionally and actively secure so if MPC protocols used after the conversion are actively secure, the whole system involving SS scheme, conversion, and MPC protocols can be unconditionally and actively secure by using our main protocols. One of our two main protocols is the first to convert from MPC-friendly SS schemes to the ramp scheme. This enhances applications, such as secure backup, of the conversion protocol. Other than the two main protocols, we propose a protocol for generating specific randomnesses and two reveal protocols as building blocks. The latter two reveal protocols are actively and unconditionally secure in the honest majority and requires O(n||F||)-bit communication per revealing, and we believe that it is independently interest.
Hot-Spot Thermal Sensor Design in FinFETs (2019)

This paper analyzes device-structure-induced and process- dependent temperature inaccuracy sources of thermal sensing applications in advanced FinFET nodes, including self-heating and Joule heating interaction , non-uniform temperature distribution in a FinFET array and distance limitation due to gate-uniformity restraints. These effects cannot be eliminated by conventional temperature calibration methods. Based on simulations and experiments, thermal behaviors of these inaccuracy sources are comprehensively characterized in this work. The goal is to mitigate the temperature gap between FinFET hot-spots and thermal sensor measurements.
Circulating tumor DNA as a cancer biomarker (2008)

4122 Background: Somatic mutations drive human tumorigenesis. Dying tumor cells release mutant gene fragments into the circulation, in principle providing exquisitely specific markers to detect the presence of neoplasia and to monitor therapeutic responses. However, the number of such mutant gene fragments is small compared to the number of normal circulating DNA fragments, making it difficult to detect and quantify them with sufficient sensitivity for meaningful clinical use. Methods: We used an extraordinarily sensitive new approach termed BEAMing (Beads, Emulsions, Amplification, and Magnetics), to quantify the amount of circulating tumor DNA (ctDNA) in plasma. In a prospective study, we studied 162 samples collected longitudinally from 18 patients undergoing surgical therapy for primary or metastatic colorectal cancer. This cohort was used to assess whether detection of circulating tumor-derived DNA could be used to monitor the effects of therapy. Results: Circulating tumor DNA was present prior to therapy in 100% of patients. The level of ctDNA fell rapidly after surgical resection, but was still detectable in the immediate post-operative period in a subset of patients. This subset included all patients whose resections were incomplete. Patients who had complete resections but still had detectable ctDNA immediately after surgery generally relapsed within one year. In contrast, patients who had no detectable ctDNA did not relapse during the period of observation. In many cases, the presence of ctDNA preceded radiographic or biochemical evidence of recurrence. Conclusions: Quantification of ctDNA by BEAMing represents a personalized genetic strategy to monitor systemic tumor burdens in patients with advanced colorectal cancers. No significant financial relationships to disclose.
IEEE 802.11be Extremely High Throughput: The Next Generation of Wi-Fi Technology Beyond 802.11ax (2019)

Wi-Fi technology is continuously innovating to cater to the growing customer demands, driven by the digitalization of everything, in the home as well as in enterprise and hotspot spaces. In this article, we introduce to the wireless community the next generation Wi-Fi, based on IEEE 802.11be Extremely High Throughput (EHT), present the main objectives and timelines of this new 802.11be amendment, thoroughly describe its main candidate features and enhancements, and cover the important issue of coexistence with other wireless technologies. We also provide simulation results to assess the potential throughput gains brought by 802.11be with respect to 802.11ax.