gebhart/patrepeval huggingface dataset:
Multiobjective reconfiguration for loss reduction and service restoration using simulated annealing (2003)

This paper presents an approach to the reconfiguration of radial distribution networks, for both loss reduction and service restoration, using the same meta-heuristic tool: the simulated annealing algorithm. Besides the main objective of each problem (minimizing losses or load not supplied) minimization of the total number of switching device operations is also included as a possible criterion. Due to these conflicting goals, the network reconfiguration is a multi-objective optimization problem. The paper shows how to generate efficient solutions for the problem and discusses the associated decision issues. A 52-bus distribution network is used to illustrate the methodology.
Table S3 from Genetic Alterations in the PI3K/AKT Pathway and Baseline AKT Activity Define AKT Inhibitor Sensitivity in Breast Cancer Patient-derived Xenografts (2023)

&lt;p&gt;RPPA data analysis&lt;/p&gt;
Inhibition of Protein Synthesis by Didemnins:  Cell Potency and SAR (2000)

Synthetic and naturally occurring didemnins are potent and specific inhibitors of protein synthesis in vitro. Structure-activity analysis indicates a requirement for the intact macrocycle; however, the smaller ring size represented by the didemnin analogue, tamandarin A, is equipotent to didemnin B. Replacement of the N,O-dimethyltyrosine by a N-methylphenylalanine or N-methylleucine residue is also well-tolerated. The rank order for inhibition of protein synthesis in vitro appears to be retained in MCF-7 cells, albeit at much higher potency. This increase in potency is explained for the first time by data indicating that MCF-7 cells can accumulate didemnin B up to 2-3 orders of magnitude compared to the growth medium.
A Fast Sub-Pixel Motion Estimation Algorithm for H.264/AVC Video Coding (2011)

Motion estimation (ME) is one of the most time-consuming parts in video coding. The use of multiple partition sizes in H.264/AVC makes it even more complicated when compared to ME in conventional video coding standards. It is important to develop fast and effective sub-pixel ME algorithms since: 1) the computation overhead by sub-pixel ME has become relatively significant while the complexity of integer-pixel search has been greatly reduced by fast algorithms, and 2) reducing sub-pixel search points can greatly save the computation for sub-pixel interpolation. In this letter, a novel fast sub-pixel ME algorithm is proposed which performs a “rough” sub-pixel search before the partition selection, and performs a “precise” sub-pixel search for the best partition. By reducing the searching load for the large number of non-best partitions, the computation complexity for sub-pixel search can be greatly decreased. Experimental results show that our method can reduce the sub-pixel search points by more than 50% compared to existing fast sub-pixel ME methods with negligible quality degradation.
Precision calcium imaging of dense neural populations via a cell body-targeted calcium indicator (2019)

Abstract Methods for one-photon fluorescent imaging of calcium dynamics in vivo are popular due to their ability to simultaneously capture the dynamics of hundreds of neurons across large fields of view, at a low equipment complexity and cost. In contrast to two-photon methods, however, one-photon methods suffer from higher levels of crosstalk between cell bodies and the surrounding neuropil, resulting in decreased signal-to-noise and artifactual correlations of neural activity. Here, we address this problem by engineering cell body-targeted variants of the fluorescent calcium indicator GCaMP6f. We screened fusions of GCaMP6f to both natural as well as engineered peptides, and identified fusions that localized GCaMP6f to within approximately 50 microns of the cell body of neurons in live mice and larval zebrafish. One-photon imaging of soma-targeted GCaMP6f in dense neural circuits reported fewer artifactual spikes from neuropil, increased signal-to-noise ratio, and decreased artifactual correlation across neurons. Thus, soma-targeting of fluorescent calcium indicators increases neuronal signal fidelity and may facilitate even greater usage of simple, powerful, one-photon methods of population imaging of neural calcium dynamics.
Pig as a model to understand the cellular immune response to Chlamydia trachomatis and suis infections (2016)

International audience
Transition from Guardrail to Concrete Bridge Rail for Low-Speed Roadways (2005)

In recent years, many state departments of transportation have had to modify their approach guardrail–to–concrete bridge rail transition systems to comply with the testing requirements of NCHRP Report 350. Generally, these transition systems are designed and tested for use on high-speed roadways. Because no national transition designs have been developed and tested for lower-speed conditions, the same transition standard is typically applied to all roadways regardless of speed. The new transition designs represent a significant increase in installation cost and complexity over some previous designs that were acceptable under NCHRP Report 230. Thus, it may be cost-prohibitive to require use of the same design on all roadways. The purpose of this research was to develop a guardrail–to–concrete bridge rail transition that is suitable for use on lower-speed roadways and that is less expensive and complex than current designs for high-speed roadways. A low-cost transition was successfully evaluated under NCHRP Report 350 Test Level 2 (TL-2) impact conditions. It is considered suitable for use on roadways that have traffic conditions appropriate for the use of TL-2 safety hardware. Use of this system provides significant savings in material and installation cost compared with high-speed (i.e., TL-3) transitions.
Definitions of terms relating to mass spectrometry (IUPAC Recommendations 2013) (2013)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
ChemInform Abstract: Hyperbranched Macromolecules via a Novel Double‐Stage Convergent Growth Approach (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
TCP Plasma Sputtering of Nanostructured Fuel Cell Electrodes (2008)

A transformer-coupled plasma sputtering reactor is used for depositing porous carbon-platinum proton exchange membrane fuel cell electrodes. Carbon nanocolumns decorated by platinum nanoclusters are thus obtained.
Effect of Shear Stress on Pseudomonas aeruginosa Isolated from the Cystic Fibrosis Lung (2016)

Biofilm formation by Pseudomonas aeruginosa is one of the hallmarks of chronic cystic fibrosis (CF) lung infections. The biofilm matrix protects this bacterium from antibiotics as well as from the immune system. Hence, the prevention or reversion of biofilm formation is believed to have a great impact on treatment of chronic P. aeruginosa CF lung infections. In the present study, we showed that it is possible to modulate the behavior of a highly adapted transmissible P. aeruginosa CF isolate at both the transcriptomic and phenotypic levels by introducing shear stress in a CF-like environment, driving it from a biofilm to a planktonic lifestyle. Consequently, the results obtained in this study are of great importance with regard to therapeutic applications that introduce shear stress in the lungs of CF patients.
Comparing artificial frustrated magnets by tuning the symmetry of nanoscale permalloy arrays (2010)

We study the impact of geometry on magnetostatically frustrated single-domain nanomagnet arrays. We examine square and hexagonal lattice arrays, as well as a brickwork geometry that combines the anisotropy of the square lattice and the topology of the hexagonal lattice. We find that the more highly frustrated hexagonal lattice allows for the most thorough minimization of the magnetostatic energy, and that the pairwise correlations between moments differ qualitatively between hexagonal and brickwork lattices, although they share the same lattice topology. The results indicate that the symmetry of local interaction is more important than overall lattice topology in the accommodation of frustrated interactions.
Demonstration of a photonic crystal surface-emitting laser pumped Yb:YAG laser (2016)

We developed a cryogenically cooled Yb:YAG continuous wave oscillator directly pumped with a photonic crystal surface-emitting laser (PCSEL). A high slope efficiency of 65.7% was obtained at an output power of 208 mW. The beam quality was close to the diffraction limit, with M<sup>2</sup><1.2 in both directions. To the best of our knowledge, this is the first PCSEL pumped solid state laser to be developed.
The Monotonic and Fatigue Properties of Osteoporotic Thoracic Vertebral Bodies (2005)

The bone mineral content is a strong predictor of the ultimate compressive load, while the percentage of the ultimate compressive load is a strong predictor of the cycles to failure for osteoporotic thoracic vertebral bodies.
N-Oxyl Radicals Trapped on Zeolite Surface Accelerate Photocatalysis (2019)

The zeolite materials have been industrially used in the thermal catalysis, but their function in photocatalysis has not been fully explored. Here we report that zeolites as supports could strengthen the radical formation after loading ferric oxide nanoparticles (FeOx/zeolite) under photoirradiation. Multiple theoretical and experimental studies demonstrate that the N-hydroxyphthalimide (NHPI) molecules could be trapped within the orifice of MFI zeolites via a sterically controllable adsorption, weakening the NO–H bonding to boost the phthalimide-N-oxyl radial (PINO·) formation. The formed radicals could activate the carbon–hydrogen bonds for accelerating the hydrocarbon oxidation into the corresponding ketones/carboxylic acids.
Unambiguous Total Synthesis of the Enantiomers of myo-Inositol 1,3,4-Trisphosphate: 1L-myo-Inositol 1,3,4-Trisphosphate Mobilizes Intracellular Ca2+ in Limulus Photoreceptors (1994)

Syntheses of the enantiomers of myo-inositol 1,3,4-trisphosphate are described. 1,4-Di-O-allyl-myo-inositol was regioselectively p-methoxybenzylated at the 3-position to give 1,4-di-O-allyl-3-O-(p-methoxybenzyl)-myo-inositol followed by benzylation of the remaining free hydroxyl groups to give the key intermediate 1,4-di-O-allyl-2,5,6-tri-O-benzyl-3-O-(p-methoxybenzyl)-myo-inositol. Removal of the p-methoxybenzyl and allyl groups gave 2,4,5-tri-O-benzyl-myo-inositol which was phosphitylated with bis(benzyloxy)(diisopropylamino)phosphine to give the fully protected trisphosphite triester. Oxidation using tert-butyl hydroperoxide gave 2,5,6-tri-O-benzyl-1,3,4-tris(dibenzylphospho)-myo-inositol, and deprotection using sodium in liquid ammonia gave racemic myo-inositol 1,3,4-trisphosphate. Deprotection of the key intermediate 1,4-di-O-allyl-2,5,6-tri-O-benzyl-3-O-(p-methoxybenzyl)-myo-inositol by isomerization of allyl groups followed by mild acid hydrolysis gave 2,4,5-tri-O-benzyl-1-O-(p-methoxybenzyl)-myo-inositol, which was converted to the diastereoisomeric (bis-(-)-camphanates. The diastereoisomers were separated by column chromatography and the camphanates and the p-methoxybenzyl group removed by saponification and acid hydrolysis, respectively, for each diastereoisomer to give the enantiomers of 2,4,5-tri-O-benzyl-myo-inositol. The absolute configurations of the latter were established by conversion of 1L-2,5,6-tri-O-benzyl-3-O-(p-methoxybenyl)-myo-inositol to the known 1L-1,2,4,5,6-penta-O-benzyl-myo-inositol. Phosphorylation and deblocking gave the D- and L-enantiomers of myo-inositol 1,3,4-trisphosphate. Biological evaluation in Limulus photoreceptors showed that 1L-myo-inositol 1,3,4-trisphosphate was much more active than the D-enantiomer, producing repetitive bursts of depolarization due to mobilization of intracellular calcium.
Towards SVC-based Adaptive Streaming in information centric networks (2015)

HTTP Adaptive Streaming (HAS) is becoming the de-facto standard for video streaming services. In HAS, each video is segmented and stored in different qualities. The client can dynamically select the most appropriate quality level to download, allowing it to adapt to varying network conditions. As the Internet was not designed to deliver such applications, optimal support for multimedia delivery is still missing. Information Centric Networking (ICN) is a recently proposed disruptive architecture that could solve this issue, where the focus is given to the content rather than to end-to-end connectivity. Due to the bandwidth unpredictability typical of ICN, standard AVC-based HAS performs quality selection sub-optimally, thus leading to a poor Quality of Experience (QoE). In this article, we propose to overcome this inefficiency by using Scalable Video Coding (SVC) instead. We individuate the main advantages of SVC-based HAS over ICN and outline, both theoretically and via simulation, the research challenges to be addressed to optimize the delivered QoE.
Enhancement mechanism of terahertz radiation from coherent longitudinal optical phonons in undoped GaAs/n-type GaAs epitaxial structures (2013)

We have investigated the characteristics of monochromatic terahertz electromagnetic waves emitted from coherent longitudinal optical (LO) phonons in undoped GaAs/n-type GaAs epitaxial structures with various thicknesses, which range from 200 nm to 1200 nm, of the undoped GaAs layer. The terahertz waves were measured at room temperature using an optical gating method with a photoconductive dipole antenna. It was found that the intensity of the terahertz waves markedly depends on the thickness of the undoped GaAs layer. The analysis of Franz-Keldysh oscillations observed with photoreflectance spectroscopy demonstrates that the built-in electric field strength in the undoped GaAs layer, which results from the Fermi-level pinning at the surface, increases from 6.1 kV/cm to 28.4 kV/cm with a decrease in the thickness. It was revealed that the amplitude of the terahertz wave is proportional to the electric field strength in the undoped GaAs layer. This fact indicates that the efficiency of the terahertz radiation is dominated by the initial polarization of the LO phonons induced by the built-in electric field, which provides us a simple strategy for the enhancement of the terahertz radiation from the coherent LO phonons.
Micromachined Patch Clamp Array LDRD Final Report (2002)

No abstract prepared.
Orthogonal Polarized Omnidirectional Antenna Composed of Halo Antenna with Parasitic Elements and Dipole Antenna (2022)

This paper proposes a small-diameter, low-profile and an omnidirectional orthogonally polarized antenna composed of a Halo antenna and a dipole antenna. As a result of the simulation, the characteristics of the proposed antenna are that the relative bandwidth is 8.8%, and the antenna height and diameter are $0.45\lambda_{0}$ and $0.13\lambda_{0}(\lambda 0$ the wavelength of the center operational frequency), respectively.
Cystine‐knot peptides targeting cancer‐relevant human cytotoxic T lymphocyte‐associated antigen 4 (CTLA‐4) (2015)

Cystine-knot peptides sharing a common fold but displaying a notably large diversity within the primary structure of flanking loops have shown great potential as scaffolds for the development of therapeutic and diagnostic agents. In this study, we demonstrated that the cystine-knot peptide MCoTI-II, a trypsin inhibitor from Momordica cochinchinensis, can be engineered to bind to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), an inhibitory receptor expressed by T lymphocytes, that has emerged as a target for the treatment of metastatic melanoma. Directed evolution was used to convert a cystine-knot trypsin inhibitor into a CTLA-4 binder by screening a library of variants using yeast surface display. A set of cystine-knot peptides possessing dissociation constants in the micromolar range was obtained; the most potent variant was synthesized chemically. Successive conjugation with neutravidin, fusion to antibody Fc domain or the oligomerization domain of C4b binding protein resulted in oligovalent variants that possessed enhanced (up to 400-fold) dissociation constants in the nanomolar range. Our data indicate that display of multiple knottin peptides on an oligomeric scaffold protein is a valid strategy to improve their functional affinity with ramifications for applications in diagnostics and therapy.
The enzymes of human diphosphoinositol polyphosphate metabolism (2013)

Diphospho-myo-inositol polyphosphates have many roles to play, including roles in apoptosis, vesicle trafficking, the response of cells to stress, the regulation of telomere length and DNA damage repair, and inhibition of the cyclin-dependent kinase Pho85 system that monitors phosphate levels. This review focuses on the three classes of enzymes involved in the metabolism of these compounds: inositol hexakisphosphate kinases, inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinases and diphosphoinositol polyphosphate phosphohydrolases. However, these enzymes have roles beyond being mere catalysts, and their interactions with other proteins have cellular consequences. Through their interactions, the three inositol hexakisphosphate kinases have roles in exocytosis, diabetes, the response to infection, and apoptosis. The two inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinases influence the cellular response to phosphatidylinositol (3,4,5)-trisphosphate and the migration of pleckstrin homology domain-containing proteins to the plasma membrane. The five diphosphoinositol polyphosphate phosphohydrolases interact with ribosomal proteins and transcription factors, as well as proteins involved in membrane trafficking, exocytosis, ubiquitination and the proteasomal degradation of target proteins. Possible directions for future research aiming to determine the roles of these enzymes are highlighted.
Comparison of Measured and Simulated Two‐Dimensional Phosphorus Diffusion Profiles in Silicon (1990)

The two‐dimensional diffusion of phosphorus has been studied by comparing profiles measured experimentally after furnace and rapid thermal annealing with simulated profiles obtained with the two‐dimensional simulators SUPREM IV and PREDICT 2. It was first shown experimentally that the effect of stress due to the window edge on chemical staining used in the measurement process is not significant to within the experimental error. It was then observed that there is considerable disagreement between measured and simulated profiles in the lateral direction, especially in the region directly under the mask edge. Possible explanations for the differences are discussed in terms of the inaccuracy of the initial implant simulation, the absence of damage annealing modeling in the simulation, and the effect of stress in the window edge vicinity on diffusion. When vacancy generation resulting from the reaction of the oxide with the underlying silicon substrate was included in the simulations, better agreement was observed with the experimental profiles.
Author response: Nuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus (2017)

Cellular and genetic approaches reveal that exposure of a normally buried nuclear export signal (NES)-like sequence mediates export of ALS-linked mutant and misfolded wild-type SOD1 to the cytoplasm by CRM1.
A slowly inactivating K+ current in retinal ganglion cells from postnatal rat (1992)

The whole-cell configuration of the patch-clamp technique was used to study voltage-gated K+ conductances in retinal ganglion cells from postnatal rat. Retinal ganglion cells were fluorescently labeled in situ, dissociated from the retina, and maintained in culture. With physiological solutions in the bath and the pipette, depolarizing voltage steps from physiological holding potentials activated Na(+)-(INa), Ca2+ (ICa), and K(+)-currents studied previously in retinal ganglion cells. Here we report on a slowly decaying K+ current, not heretofore reported in rat. With 4-AP, TEA, and Co2+ in the bath, to block IA, IK, and IK(Ca), respectively, a slowly decaying outward current was activated from -80 mV by steps positive to -40 mV. This current was present in 92% of all ganglion cells tested (n = 83). It activated within 10 ms and inactivated with a voltage-independent time constant of about 70 ms at 35 degrees C. Inactivation was voltage-dependent, half-maximal at -55 mV, and almost complete at 0 mV. The current was blocked by internal Cs+ and TEA, or by external application of 1 mM Ba2+, but not by 3 mM extracellular Co2+. The biophysical and pharmacological properties of this current are distinctly different from those of slowly inactivating K+ currents studied in other rat neurons. It was very similar, however, to a slowly inactivating K+ current previously reported in ganglion cells of tiger salamander retina. This last finding indicates conservation of a defined K+ channel type in functionally related cells in both lower vertebrates and mammals.
New Approaches in Accelerating Material Development Through Structure-to-Property Relationships built from XPS and Microscopic Data (2008)

Extended abstract of a paper presented at Microscopy and Microanalysis 2008 in Albuquerque, New Mexico, USA, August 3 – August 7, 2008
Methodology for Imaging Nano-to-Microscale Water Condensation Dynamics on Complex Nanostructures (2011)

A better understanding of the role that nanoscale surface chemical heterogeneities and topographical features play in water droplet formation is necessary to improve design and robustness of nanostructured superhydrophobic surfaces as to make them fit for industrial applications. Lack of an imaging method capable of capturing the water condensation process on complex nanostructures with required magnification has thus far hindered experimental progress in this area. In this work, we demonstrate that by transferring a small part of a macroscale sample to a novel thermally insulated sample platform we are able to mitigate flooding and electron heating problems typically associated with environmental scanning electron microscopy of water condensation. We image condensation dynamics on individual complex particles and a superhydrophobic network of nanostructures fabricated from low thermal conductivity materials with an unobstructed 90° perspective of the surface-to-water interface with field of view as small as 1 μm(2). We clearly observe the three-stage drop growth process and demonstrate that even during late stages of the droplet growth the nearly spherical drop remains in a partially wetting Wenzel state.