gebhart/patrepeval huggingface dataset:
Designing and Testing Broadly-Protective Filoviral Vaccines Optimized for Cytotoxic T-Lymphocyte Epitope Coverage (2012)

We report the rational design and in vivo testing of mosaic proteins for a polyvalent pan-filoviral vaccine using a computational strategy designed for the Human Immunodeficiency Virus type 1 (HIV-1) but also appropriate for Hepatitis C virus (HCV) and potentially other diverse viruses. Mosaics are sets of artificial recombinant proteins that are based on natural proteins. The recombinants are computationally selected using a genetic algorithm to optimize the coverage of potential cytotoxic T lymphocyte (CTL) epitopes. Because evolutionary history differs markedly between HIV-1 and filoviruses, we devised an adapted computational technique that is effective for sparsely sampled taxa; our first significant result is that the mosaic technique is effective in creating high-quality mosaic filovirus proteins. The resulting coverage of potential epitopes across filovirus species is superior to coverage by any natural variants, including current vaccine strains with demonstrated cross-reactivity. The mosaic cocktails are also robust: mosaics substantially outperformed natural strains when computationally tested against poorly sampled species and more variable genes. Furthermore, in a computational comparison of cross-reactive potential a design constructed prior to the Bundibugyo outbreak performed nearly as well against all species as an updated design that included Bundibugyo. These points suggest that the mosaic designs would be more resilient than natural-variant vaccines against future Ebola outbreaks dominated by novel viral variants. We demonstrate in vivo immunogenicity and protection against a heterologous challenge in a mouse model. This design work delineates the likely requirements and limitations on broadly-protective filoviral CTL vaccines.
ChemInform Abstract: Calcium, Strontium, and Barium Cyclooctatetraenediyl Complexes: Synthesis of a Stable Phosphacyclopropane (Structurally Authenticated). (1990)

Abstract Cyclooctatetraene (I) is treated with vapours of the metals (II) in tetrahydrofuran (III) to give the complexes (IV) which release THF, forming the pyrophoric compounds (V).
CdTe, CIGS and a-Si thin film PV technologies: factors impacting LCOE (2011)

We describe thin film photovoltaic (PV) technologies that have been scaled in manufacturing, and contrast their attributes and how they impact the levelized cost of electricity (LCOE). The thin film PV technologies reviewed include cadmium telluride (CdTe), copper indium gallium selenide (CIGS), amorphous silicon (a-Si), and microcrystalline/amorphous silicon (&#956;/a-Si) produced by a variety of methods. The factors studied include conversion efficiency, energy yield under different lighting and environmental conditions, location dependence, tracked/fixed tilt differential performance, uptime, output degradation rate, failure rate, lifetime, module cost, balance of system (BOS) and inverter cost, installation cost, land cost, operation cost, maintenance cost and finance cost. These thin film PV technologies are compared with crystalline silicon, the most widely deployed PV technology.
A bi-directional inductive power transfer system with individually controlled tracks and pick-ups (2013)

Bi-directional inductive power transfer (BDIPT) technique is attractive for applications, such as electric vehicles (EVs), for the realization of vehicle-to-grid (V2G) systems. This paper presents a circuit topology to individually control magnitude and direction of power flow from grid to multiple EVs. The proposed system employs two inductor-capacitor-inductor (LCL) parallel resonant circuits together with a segmented switching converter and two pick-ups, to facilitate individual control of power flow. A mathematical model is presented, showing the individual controllability of bi-directional power flow between the tracks and the pick-ups. Validity of the proposed concept is demonstrated through simulation results of a 1.5 kW IPT system. Results indicate that the proposed topology is feasible, and ideal for applications where bi-directional power flow needs to be controlled individually within `N' numbers of tracks and pick-ups.
Measurement of distributions sensitive to the underlying event in inclusive Z-boson production in $$pp$$ p p collisions at $$\sqrt{s}=7$$ s = 7 TeV with the ATLAS detector (2014)

A measurement of charged-particle distributions sensitive to the properties of the underlying event is presented for an inclusive sample of events containing a [Formula: see text]-boson, decaying to an electron or muon pair. The measurement is based on data collected using the ATLAS detector at the LHC in proton-proton collisions at a centre-of-mass energy of [Formula: see text] TeV with an integrated luminosity of [Formula: see text] fb[Formula: see text]. Distributions of the charged particle multiplicity and of the charged particle transverse momentum are measured in regions of azimuthal angle defined with respect to the [Formula: see text]-boson direction. The measured distributions are compared to similar distributions measured in jet events, and to the predictions of various Monte Carlo generators implementing different underlying event models.
CCDC 250254: Experimental Crystal Structure Determination (2006)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Normal Development in Mice Over-Expressing the Intracellular Domain of DLL1 Argues against Reverse Signaling by DLL1 In Vivo (2013)

The Notch signaling pathway mediates the direct communication between adjacent cells and regulates multiple developmental processes. Interaction of the Notch receptor with its ligands induces the liberation of the intracellular portion of Notch (NICD) referred to as regulated intramembraneous proteolysis (RIP). NICD translocates to the nucleus, and by complexing with the DNA binding protein RBPjκ and other cofactors activates transcription of bHLH genes. RIP-like processing of various mammalian Notch ligands (DLL1, JAG1 and JAG2) and the translocation of their intracellular domains (ICDs) to the nucleus has also been observed. These observations together with effects of over-expressed ligand ICDs in cultured cells on cell proliferation, differentiation, and Notch activity and target gene expression have led to the idea that the intracellular domains of Notch ligands have signaling functions. To test this hypothesis in vivo we have generated ES cells and transgenic mice that constitutively express various versions of the intracellular domain of mouse DLL1. In contrast to other cell lines, expression of DICDs in ES cells did not block proliferation or stimulate neuronal differentiation. Embryos with ubiquitous DICD expression developed to term without any apparent phenotype and grew up to viable and fertile adults. Early Notch-dependent processes or expression of selected Notch target genes were unaltered in transgenic embryos. In addition, we show that mouse DICD enters the nucleus inefficiently. Collectively, our results argue against a signaling activity of the intracellular domain of DLL1 in mouse embryos in vivo.
Speed performances of thin-film lateral SOI PIN photodiodes up to tens of GHz (2006)

The present paper investigates performances of SOI PIN detectors in function of their intrinsic length, L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> . Our original model, fully validated by Atlas 2D numerical simulations and measurements, allows to predict and optimize their speed performances for the target applications
Solvent Effects on High Temperature Polyimides and their Bonded Joints (1999)

Abstract Environmental stress crazing/cracking (ESCR/C) of adhesives under organic solvent exposure is a subject of great practical importance to adhesive end-users, especially in dealing with structural applications. In the past, the mechanical properties of several adhesive systems have been shown to degrade considerably after both prolonged and momentary exposure to solvents under a state of stress. In this study, the solvent resistance of three structural polyimide adhesives was studied, with respect to organic solvents that may come in contact with the adhesives during their service life. Initially, dog-bone samples of the resin systems were prepared, according to ASTM Standard D638–91a, and these were soaked in the solvents to obtain equilibrium solvent mass uptake curves. The solvents used in the study included acetone, methyl ethyl ketone (MEK) and ethylene glycol, among others. The equilibrated samples were then tested in a miniature tensile testing machine, to obtain stress-strain characteristics. Secondly, samples equilibrated in the solvents were held in a vacuum environment at 150°C (which is below the glass transition temperature of the adhesives) to desorb the solvent, and these were then tested to obtain residual properties. To study the durability of bonded joints under solvent exposure, Ti-6A1-4V/adhesive bonds were prepared and wedge tests were performed on them for periods up to several days in solvent baths. Based on the measured crack lengths, the strain energy release rate due to solvent-induced environmental stress cracking (G ESC) was computed as a function of crack growth rate. The G ESC measurements help quantify the durability of the bonded joints on exposure to the various solvents, and further help in ranking the adhesives in terms of solvent resistance.
Vacuum gas chromatography using short glass capillary columns combined with mass spectrometry (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVacuum gas chromatography using short glass capillary columns combined with mass spectrometryFrank W. Hatch and Milton E. ParrishCite this: Anal. Chem. 1978, 50, 8, 1164–1168Publication Date (Print):July 1, 1978Publication History Published online1 May 2002Published inissue 1 July 1978https://pubs.acs.org/doi/10.1021/ac50030a039https://doi.org/10.1021/ac50030a039research-articleACS PublicationsRequest reuse permissionsArticle Views124Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Differential Absorption Measurements by a Phase Difference Technique (1969)

Measurements of the phase difference between the signals from ionospherically propagated radio waves received on a vertical whip antenna and on a horizontal dipole at the same location are shown to lead to an estimate of the relative powers in the ordinary and extraordinary components when the propagation path is such that quasi‐longitudinal approximations may be used. The technique is valid for incoherent signals, where the incoming waves are considered to be made up of many individual rays. When spaced antennas are used, an estimate of the mean difference in bearing angle between the ordinary and extraordinary components is possible.
High-Sensitivity Magnetometry Based on Quantum Beats in Diamond Nitrogen-Vacancy Centers (2013)

We demonstrate an absolute magnetometer based on quantum beats in the ground state of nitrogen-vacancy centers in diamond. We show that, by eliminating the dependence of spin evolution on the zero-field splitting D, the magnetometer is immune to temperature fluctuation and strain inhomogeneity. We apply this technique to measure low-frequency magnetic field noise by using a single nitrogen-vacancy center located within 500 nm of the surface of an isotopically pure (99.99% 12C) diamond. The photon-shot-noise limited sensitivity achieves 38 nT/sqrt[Hz] for 4.45 s acquisition time, a factor of sqrt[2] better than the implementation which uses only two spin levels. For long acquisition times (>10 s), we realize up to a factor of 15 improvement in magnetic sensitivity, which demonstrates the robustness of our technique against thermal drifts. Applying our technique to nitrogen-vacancy center ensembles, we eliminate dephasing from longitudinal strain inhomogeneity, resulting in a factor of 2.3 improvement in sensitivity.
A multidisciplinary combinatorial approach for tuning promising hydrogen storage materials towards automotive applications (2011)

HyStorM is a multidisciplinary hydrogen-storage project aiming to synthesise and tune materials hydrogen storage properties for automotive applications. Firstly, unique high-throughput combinatorial thin-film technologies are used to screen materials' hydrogen storage properties. Then promising thin-film candidate compositions are synthesised and examined in the bulk. In this paper, we report on our results within the ternary compositions Mg-Ti-B and Ca-Ti-B. Primary screening of the Mg-Ti-B ternary identified a high capacity hotspot corresponding to Mg0.36Ti0.06B0.58, with 10.6 wt% H2 capacity. Partial reversibility has been observed for this material in the thin-film. Bulk Ti-doped Mg(BH4)2 composites show rehydrogenation to MgH2 under the conditions used. The synthesised thin-film Ca-Ti-B ternary showed only low hydrogen storage capacities. In the bulk, Ti-doping experiments on Ca(BH4)2 demonstrated reversible storage capacities up to 5.9 wt% H2. Further characterisation experiments are required to decipher the role of the Ti-dopant in these systems in both films and in the bulk.
Synergy of terrestrial and satellite measurements for study of atmospheric aerosol in the Eurasian Economic Union’s countries (2018)

The development of the scientific, methodological and technical basis for an integrated terrestrial and satellite monitoring of the atmosphere and the Earth's surface over the Eurasian continent is the goal of an international project carried out by the scientific organizations of Belarus, Russia, Mongolia and Vietnam with the support of the Eurasian Association for the Support of Scientific Research (EAPS). The report presents the results of testing the method of coordinated terrestrial and satellite, lidar and radiometric measurements to study altitude profiles of aerosol parameters in the areas of AERONET stations in the countries participating in the project. The data of the satellite lidar CALIOP and the solar radiometer were processed by the algorithms developed in the frame of combined lidar and radiometric sounding technique (LRS). Coordinated multiwavelength lidar measurements were carried out at remote sensing stations in IPNASB (Minsk, Belarus), IAO (Tomsk, Russia) and KRSU (Teplokluchenka, Kyrgyzstan) to validate the results of satellite data processing.
Day-to-Day Variation of the Angular Distribution of Lightning Activity Calculated from ELF Magnetic Measurements (2009)

We study the “local” distribution of lightning activity on the Earth calculated from Extremely Low Frequency (ELF) magnetic field variations. Lightning generates strong electromagnetic impulses recorded in the ELF band as short signal spikes. Using two perpendicular magnetic antennas at our Hylaty station, we calculate the azimuths of the sources of such spikes. These ELF data are compared with selected satellite measurements available on NASA and BADC web centres. For the winter period January 8 to 9, 2006, analysed in detail, a large cyclone was observed over the Mediterranean Sea (MS). The cyclone was created in the western part of the MS and then moved eastwards along the North coast of Africa. The absence of lightning activity nearer our station allowed us to compare the ELF measurements with observations of this cyclone made from the TRMM and Meteosat‐7 satellites, using Lightning Imaging Sensor observations and full Earth disk images, respectively. The analysis proves that ELF measurements can be used for on‐line monitoring of lightning activity in the vicinity of the measuring ELF station, with the radius of effective observations being more than 2000 km. This inexpensive method can easily be used in areas without other lightning monitoring systems, or it can supplement existing ones.
Impact of power control optimization on the system performance of relay based LTE-Advanced heterogeneous networks (2011)

Decode-and-forward relaying is a promising enhancement to existing radio access networks and is already standardized in 3rd generation partnership project (3GPP) as a part of long term evolution (LTE)-Advanced Release 10. Two inband operation modes of relay nodes are supported, namely type 1 and type 1b. Relay nodes promise to offer considerable gain for system capacity or coverage, depending on the deployment prioritization, in a cost-efficient way. Yet, in order to fully exploit the benefits of relaying, the inter-cell interference which is increased due to the presence of relay nodes should be limited. Moreover, large differences in the received power levels from different users should be avoided. The goal is to keep the receiver dynamic range low in order to retain the orthogonality of the single carrier-frequency division multiple access system. In this paper, an evaluation of the relay based heterogeneous deployment within the LTE-Advanced uplink framework is carried out by applying the standardized LTE Release 8 power control scheme both at evolved node B and relay nodes. In order to enhance the overall system performance, different power control optimization strategies are proposed for 3GPP urban and suburban scenarios. A comparison between type 1 and type 1b relay nodes is as well presented to study the effect of the relaying overhead on the system performance in inband relay deployments. Comprehensive system level simulations show that the power control is a crucial means to increase the cell edge and system capacities, to mitigate inter-cell interference and to adjust the receiver dynamic range for both relay node types.
Optical Path Aggregation for 1-Tb/s Transmission in Spectrum-Sliced Elastic Optical Path Network (2010)

We propose and experimentally demonstrate optical path aggregation in a spectrum-sliced elastic optical path network (SLICE). Multiple optical orthogonal frequency-division-multiplexed (OFDM) 100-Gb/s optical paths are aggregated in the optical domain to form a spectrally continuous 1-Tb/s super-wavelength optical path and transmitted over a network of bandwidth-variable wavelength cross-connects. We evaluate the potential implementation issues and conclude that the OFDM paths can be optically aggregated with optical signal-to-noise ratio penalty of less than 1 dB.
Evaluation of the probability of dynamic failure and processor utilization for real-time systems (2003)

It is shown how to determine closed-form expressions for task scheduling delay and active task time distributions for any real-time system application, given a scheduling policy and task execution time distributions. The active task time denotes the total time a task is executing or waiting to be executed, including scheduling delays and resource contention delays. The distributions are used to determine the probability of dynamic failure and processor utilization, where the probability of dynamic failure is the probability that any task will not complete before its deadline. The opposing effects of decreasing the probability of dynamic failure and increasing utilization are also addressed. The analysis first addresses workloads where all tasks are periodic, i.e., they are repetitively triggered at constant frequencies. It is then extended to include the arrival of asynchronously triggered tasks. The effects of asynchronous tasks on the probability of dynamic failure and utilization are addressed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Tables S1, S4, S5 from The c-Myc Oncogene Directly Induces the H19 Noncoding RNA by Allele-Specific Binding to Potentiate Tumorigenesis (2023)

Supplementary Tables S1, S4, S5 from The c-Myc Oncogene Directly Induces the H19 Noncoding RNA by Allele-Specific Binding to Potentiate Tumorigenesis
Measurement of the direct energy gap ofAl0.5In0.5P: Implications for the band discontinuity atGa1−xInxP/AlyIn1−yP heterojunctions (1994)

In a recent paper [Phys. Rev. B 48, 18 031 (1993)], Patel and co-workers described hydrostatic-pressure-dependent photoluminescence measurements performed on ${\mathrm{Ga}}_{0.47}$${\mathrm{In}}_{0.53}$P/${\mathrm{Al}}_{0.5}$${\mathrm{In}}_{0.5}$P multiple quantum wells. They determined directly a valence-band offset of 0.24\ifmmode\pm\else\textpm\fi{}0.05 eV from the energy difference between the indirect transition in the barrier and the transition from X states in the barrier to hh1 valence-band states in the quantum well, when extrapolated to zero pressure. The conduction-band offset was then indirectly determined to be 0.26 eV from the total-band discontinuity of the system, assuming a value of 2.45 eV for the (low temperature) lowest-energy direct gap of ${\mathrm{Al}}_{0.5}$${\mathrm{In}}_{0.5}$P. This yields a band-offset ratio, \ensuremath{\Delta}${\mathit{E}}_{\mathit{c}}$:\ensuremath{\Delta}${\mathit{E}}_{\mathit{v}}$, of 52:48. Here, we present evidence that the (5 K) direct gap of the ${\mathrm{Al}}_{0.5}$${\mathrm{In}}_{0.5}$P barrier is \ensuremath{\sim}2.685 eV, which results in a revised band-offset ratio of 67:33, similar to recent values determined for ${\mathrm{Ga}}_{1\mathrm{\ensuremath{-}}\mathit{x}}$${\mathrm{In}}_{\mathit{x}}$P/(${\mathrm{Al}}_{\mathit{y}}$${\mathrm{Ga}}_{1\mathrm{\ensuremath{-}}\mathit{y}}$${)}_{0.5}$${\mathrm{In}}_{0.5}$P heterojunctions.
Solvent and pressure effects on the photoluminescence in porous Si (1995)

The photoluminescence band in porous Si is found to shift monotonically toward lower energy at a rate of −(18±5) meV/GPa if a hydrostatic pressure of up to 5 GPa is applied with liquid argon, in contrast to a convex behavior of the shift observed when a methanol–ethanol mixture is used as the pressure-transmitting medium. The data show that the electronic energy gap relevant to the luminescence is intrinsically reduced by the hydrostatic compression but has a distinct solvatochromic character.
"FRCEF: The new friction reduced and coupling enhanced finger for the Awiwi hand" (2015)

The combination of tendon driven robotic fingers and variable impedance actuation in the DLR hand arm system brings benefits in robustness and dynamics by enabling energy storage. Since the force measurement and motors are in the forearm the tendon path should have low friction for accurate movements and precise finger control. In this paper an enhanced generation of the Awiwi hand finger design is presented. It reduces the friction in the actuation system about 20 percent and increases the maximum fingertip force about 33 percent. A test finger was designed to evaluate different tendon couplings and to test a magnetic sensor to measure the joint position. In a next step a new finger design for DLR hand arm system has been developed. Finally, the low friction and the robustness are proven using several experiments.