gebhart/patrepeval huggingface dataset:
ODSurf : Modélisation et réalisation d'une couche de roulement de chaussée optimisée, dense et peu bruyante (2016)

ODSurf project is following a previous P2RN project dealing with the emission and propagation of rolling noise, carried out in the framework of the German-French collaboration DEUFRAKO. During P2RN, an optimum pavement texture in terms of the noise emission was calculated. The current ODSurf project was mainly dedicated to the development and implementation of low noise new technologies and new materials adapted to urban environment. Original solutions have been investigated, implemented and tested on-site. In parallel to these technological approaches, new models have been developed to better characterize various physical phenomena produced when a tyre is rolling on a textured pavement. Vibration phenomena, air pumping and the horn effect were specifically studied and the main results are detailed in this document. In addition to the modelling approach, this project includes a strong experimental component useful for model validation and also to allow an acoustic classification of road surfaces. The measures presented in this report were carried out both on test tracks and actual site on which were positioned the optimized conventional or industrially designed coatings, both in France and Germany. Finally, this report is ending with the common database "DEUFRABASE". It includes the noise produced by light and heavy vehicles running on a large panel of French and German road surfaces for various propagation configurations. Updated at the end of the project, this database posted on the Ifsttar server will be soon freely available online. From its current design, it will easily allow regular updates in terms of site configurations and new road surfaces. It thus will be a good tool to estimate the acoustic impact of traffic for many suburban and urban situations. Following the results achieved during the project, the next steps will concern on one hand, the improvement and integration of the various modelling approaches of different tyre noise generation phenomena in a "unique" tool in order to have an overall estimation of the impact of road surfaces on the sound level produced by road traffic and secondly, to extend the DEUFRABASE to more realistic situations.
Wavelength Routing and Multicasting Network in Ring-Based Integrated Photonics (2015)

Wavelength routing and multicasting network is demonstrated in cross-grid waveguide structure. High channel efficiency and extensibility to a large-scale system are achieved with 0.5mW tuning power and 0.8dB power penalty among all casting functions.
Data from Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth (2023)

&lt;div&gt;Abstract&lt;p&gt;Invadopodia are actin-based proteolytic membrane protrusions required for invasive behavior and tumor growth. In this study, we used our high-content screening assay to identify kinases whose activity affects invadopodia formation. Among the top hits selected for further analysis was TAO3, an STE20-like kinase of the GCK subfamily. TAO3 was overexpressed in many human cancers and regulated invadopodia formation in melanoma, breast, and bladder cancers. Furthermore, TAO3 catalytic activity facilitated melanoma growth in three-dimensional matrices and &lt;i&gt;in vivo&lt;/i&gt;. A novel, potent catalytic inhibitor of TAO3 was developed that inhibited invadopodia formation and function as well as tumor cell extravasation and growth. Treatment with this inhibitor demonstrated that TAO3 activity is required for endosomal trafficking of TKS5α, an obligate invadopodia scaffold protein. A phosphoproteomics screen for TAO3 substrates revealed the dynein subunit protein LIC2 as a relevant substrate. Knockdown of LIC2 or expression of a phosphomimetic form promoted invadopodia formation. Thus, TAO3 is a new therapeutic target with a distinct mechanism of action.&lt;/p&gt;Significance:&lt;p&gt;An unbiased screening approach identifies TAO3 as a regulator of invadopodia formation and function, supporting clinical development of this class of target.&lt;/p&gt;&lt;/div&gt;
Structural Insight into the Self-Assembly of a Pharmaceutically Optimized Insulin Analogue Obtained by Small-Angle X-ray Scattering (2020)

B29N<sup>ε</sup>-lithocholyl-γ-l-βGlu-desB30 human insulin [NN344] belongs to a group of insulins with fatty acid or sterol modifications. These insulin analogues have been found to form subcutaneous depots upon injection and hereby have a protracted release profile <i>in vivo</i>. In the present study, B29N<sup>ε</sup>-lithocholyl-γ-l-Glu-desB30 human insulin was investigated using in-solution small-angle X-ray scattering (SAXS) at chemical conditions designed to mimic three stages during treatment <i>in vivo</i>: in-vial/pen, postinjection, and longer times after injection. We found that the specific insulin analogue formed a mixture of mono- and dihexamers under in-vial/pen conditions of low salt and stabilizing phenol. At postinjection, conditions mimicking a subcutaneous depot, B29N<sup>ε</sup>-lithocholyl-γ-l-Glu-desB30 human insulin, formed very long straight soluble hexamer-based rods stacked along the Zn(II)-axis. The self-assembly was triggered by an increase in salt concentration when going from vial to physiological conditions. Mimicking longer times after injection and the additional removal of phenol caused the length of the rods to decrease significantly. Finally, we found that the self-assembly could be controlled by varying the amount of modification at the interaction interface by making mixed hexamers of B29N<sup>ε</sup>-lithocholyl-γ-l-Glu-desB30 and desB30 human insulin. This opens extra possibilities for controlling the release profile of very-long-acting insulins.
Mechanisms of MARCKS Gene Activation during XenopusDevelopment (1997)

The myristoylated alanine-rich protein kinase C substrate (MARCKS) is a high affinity cellular substrate for protein kinase C. The MARCKS gene is under multiple modes of transcriptional control, including cytokine- and transformation-dependent, cell-specific, and developmental regulation. This study evaluated the transcriptional control of MARCKS gene expression during early development of Xenopus laevis. Xenopus MARCKS was highly conserved with its mammalian and avian homologues; its mRNA and protein were abundant in the maternal pool and increased after the mid-blastula transition (MBT). The Xenopus MARCKS gene was similar to those of other species, except that a second intron interrupted the 5'- untranslated region. By transiently transfecting XTC-2 cells and microinjecting Xenopus embryos with reporter gene constructs containing serial deletions of 5'-flanking MARCKS sequences, we identified a 124-base pair minimal promoter that was critical for promoter activity. Developmental gel shift assays revealed that a CBF/NF-Y/CP-1-like factor and an Sp1-like factor bound to this region in a manner correlating with the onset of Xenopus MARCKS transcription at MBT. Mutations in the promoter that abolished binding of these two factors also completely inhibited transcriptional activation of the MARCKS gene at MBT. The binding sites for these two factors are highly conserved in the human and mouse MARCKS promoters, suggesting that these elements might also regulate MARCKS transcription in other species. These studies not only increase our knowledge of the transcriptional regulation of the MARCKS genes but also have implications for the mechanisms responsible for zygotic activation of the Xenopus genome at MBT.
An efficient robot arm control under geometric path constraints (1983)

Conventionally, robot control algorithms are divided into two stages, namely, path planning and path tracking (or path control) This division has been adopted mainly as a means of alleviating difficulties in dealing with complex, coupled robot arm dynamics. Unfortunately, the simplicity obtained from the division comes at the expense of efficiency in utilizing robot's capabilities. To remove at least partially this inefficiency, this paper considers a solution to the problem of moving a robot arm in minimum time along a specified geometric path subject to input torque/force constraints. We first describe the robot arm dynamics using parametric functions which represent geometric path constraints to be honored for collision avoidance as well as task requirements. Secondly, constraints on input torques/forces are converted to those on the parameters. Finally, the minimum-time solution is deduced in an algorithm form using phase-plane techniques.
2. B (2002)

PreviousNext No AccessEncyclopedic Dictionary of Applied Geophysics, Fourth edition2. BAuthors: Robert E. SheriffRobert E. SheriffProfessor, University of Houstonhttps://doi.org/10.1190/1.9781560802969.chb SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.9781560802969.chbFiguresReferencesRelatedDetailsCited ByAn Automation Engine to Improve Seismic Operations in Exploration13 January 2020An Automation Engine to Improve Seismic Operations in Exploration13 January 2020Complex Semblance and Its Application8 June 2018 | Journal of Earth Science, Vol. 30, No. 4 Encyclopedic Dictionary of Applied Geophysics, Fourth editionISBN (print):978-1-56080-118-4ISBN (online):978-1-56080-296-9Copyright: 2002 Pages: 442 publication data© 2002 All rights reserved. No part of this publication may be reproduced or distributed in any form or by any means without written permission of the publisherPublisher:Society of Exploration Geophysicists HistoryPublished in print: 01 Jan 2002 CITATION INFORMATION Robert E. Sheriff, (2002), "2. B," Geophysical References Series : 30-44. https://doi.org/10.1190/1.9781560802969.chb Plain-Language Summary PDF DownloadLoading ...
Two-dimensional transonic aerodynamic design method (1987)

This paper demonstrates the capabilities of a new transonic, two-dimensional design method, based on the simultaneous solution of multiple streamtubes, coupled through the position of, and pressure at, the streamline interfaces. This allows the specification of either the airfoil shape (direct, analysis mode) or the airfoil surface pressure distribution (inverse, design mode). The nonlinear system of equations is formulated in a conservative manner, which guarantees the correct treatment of shocks, and is solved by a rapid Newton solution method. Viscous effects can also be included through a coupled integral boundary-layer analysis. The first set of results shows the effect of different far-field treatments, demonstrating the improvement in accuracy obtained by including the second-order doublet terms in addition to the usual first-order vortex term. The results are also compared to those obtained by specifying straight far-field streamlines (corresponding to solid-wall wind-tunnel experiments) or constant far-field pressure (corresponding to freejet experiments) to show the sensitivity to the farfield distance. In the second set of results, the design method is used to design a transonic airfoil with C/ = 1.000 at A/oo = 0.70. It is shown that the off-design performance is improved by specifying a surface pressure distribution with a very weak shock.
Time Evolution of the Potential Distribution in Earth Alkaline Titanates under de Voltage Stress (1988)

Abstract Earth alkaline titanates which are commonly used as dielectrics in ceramic capacitors may exhibit a long‐term degradation of the insulation resistance under simultaneous dc field and temperature stress. In order to study the nature of this process, it is necessary to detect the time evolution of the potential distribution between anode and cathode. A method is introduced which allows the determination of the potential distribution by the electrostatic deflection of an electron beam close to the edge of a current‐carrying sample. The results are used to evaluate various models which have been proposed to explain the mechanism of the degradation process.
New synthesis of 6″‐[18F]fluoromaltotriose for positron emission tomography imaging of bacterial infection (2020)

6″-[<sup>18</sup> F]fluoromaltotriose is a positron emission tomography tracer that can differentiate between bacterial infection and inflammation in vivo. Bacteria-specific uptake of 6″-[<sup>18</sup> F]fluoromaltotriose is attributed to the targeting of maltodextrin transporter in bacteria that is absent in mammalian cells. Herein, we report a new synthesis of 6″-[<sup>18</sup> F]fluoromaltotriose as a key step for its clinical translation. In comparison with the previously reported synthesis, the new synthesis features unambiguous assignment of the fluorine-18 position on the maltotriose unit. The new method utilizes direct fluorination of 2″,3″,4″-tri-O-acetyl-6″-O-trifyl-α-D-glucopyranosyl-(1-4)-O-2',3',6'-tri-O-acetyl-α-D-glucopyranosyl-(1-4)-1,2,3,6-tetra-O-acetyl-D-glucopyranose followed by basic hydrolysis. Radiolabeling of the new maltotriose triflate precursor proceeds using a single HPLC purification step, which results in shorter reaction time in comparison with the previously reported synthesis. Successful synthesis of 6″-[<sup>18</sup> F]fluoromaltotriose has been achieved in 3.5 ± 0.3% radiochemical yield (decay corrected, n = 7) and radiochemical purity above 95%. The efficient radiosynthesis of 6″-[<sup>18</sup> F]fluoromaltotriose would be critical in advancing this positron emission tomography tracer into clinical trials for imaging bacterial infections.
Area Expansion and Permeation of Phospholipid Membrane Bilayers by Influenza Fusion Peptides and Melittin (1998)

The fusion of membrane bilayers is an ubiquitous cellular process. Exocytosis, organelle formation, cellular trafficking, cell division, fertilization, and numerous other cellular activities all involve membrane fusion. Fusion can be rapid, occurring on the order of seconds or minutes. In viral infection, specific glycoproteins mediate the fusion of the viral lipid envelope with a cellular membrane. Viral fusion glycoproteins typically contain a segment which embeds into the target cellular membrane, referred to as the fusion peptide. The mechanism of action of viral fusion proteins is still not certain; in particular, the extent and rate of insertion of the fusion peptide are not well quantified. In this report, we use micropipet aspiration and video microscopy of large unilamellar phosphatidylcholine vesicles to determine the membrane area expansion resulting from the insertion of fusion peptides into the lipid bilayer. The fusion peptide of the viral fusion protein, influenza hemagglutinin, inserts into phosphatidylcholine bilayers, resulting in an increase in the membrane area on a time scale (i.e., seconds) similar to that of viral fusion. Following peptide insertion, porous defects form in minutes. We show that chemical changes in the N- and C-termini of this peptide can either eliminate, decrease, or enhance surface activity of the peptide; particularly the propensity to form pores can be diminished. In control studies, the well-studied lytic peptide, melittin, similarly increases the membrane area and forms pores in the membrane. The observation that the wild-type influenza fusion peptide and melittin each form pores below the areal expansion limit of 5% suggest that membrane disrupting proteins act through specific and localized perturbation.
Involvement of azomethine ylides in the thermal rearrangement of aziridinyl ketones to pyrroles (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInvolvement of azomethine ylides in the thermal rearrangement of aziridinyl ketones to pyrrolesAlbert Padwa, David Dean, and Toyonari OineCite this: J. Am. Chem. Soc. 1975, 97, 10, 2822–2829Publication Date (Print):May 1, 1975Publication History Published online1 May 2002Published inissue 1 May 1975https://pubs.acs.org/doi/10.1021/ja00843a035https://doi.org/10.1021/ja00843a035research-articleACS PublicationsRequest reuse permissionsArticle Views175Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Deep roto-translation scattering for object classification (2015)

Dictionary learning algorithms or supervised deep convolution networks have considerably improved the efficiency of predefined feature representations such as SIFT. We introduce a deep scattering convolution network, with complex wavelet filters over spatial and angular variables. This representation brings an important improvement to results previously obtained with predefined features over object image databases such as Caltech and CIFAR. The resulting accuracy is comparable to results obtained with unsupervised deep learning and dictionary based representations. This shows that refining image representations by using geometric priors is a promising direction to improve image classification and its understanding.
An implantable, rechargeable neuromodulation research tool using a distributed interface and algorithm architecture (2015)

Implantable medical devices can provide chronic access to the nervous system. Implants containing embedded scientific instrumentation payloads (e.g. - sensors, classification, and control policy implementation) provide a unique opportunity for exploring diseased neural networks and how these neural networks may be better treated. Physically embedding payloads in an implant creates intertwined constraints such as power consumption, algorithmic computation limits and lack of flexibility, data storage, and the scale of sensing information. These limitations can be largely addressed with a combination of rechargeable batteries and high-bandwidth, secure, distance telemetry, which enables a distributed neural research system. Taking advantage of a distributed architecture helps facilitate scientific investigation in a more unconstrained environment. In this paper, we describe the design of an implantable research tool, discuss the prototype system architecture and its design details, and present preliminary bench verification and validation with human data drawn from representative use cases.
Almost Surely Stable Deep Dynamics (2020)

We construct DNN-based dynamic models with implicit stability guarantees.<br><br>
Low onset voltage of GaN on Si Schottky barrier diode using various recess depths (2014)

A low onset voltage AlGaN/GaN diode with a width of 14 mm is achieved. The recess depth of the AlGaN layer is responsible for the low onset voltage. In comparison with the conventional non‐recessed diode, the onset voltage reduces by 45% along with a decrease of reverse leakage current by about one order of magnitude.
Sampling biases in network path measurements and what to do about it (2009)

We show that currently prevalent practices for network path measurements can produce inaccurate inferences because of sampling biases. The inferred mean path latency can be more than a factor of two off the true mean. We present the Broom toolkit that has three methods to correct for this bias. Broom places no burden on the measurement process itself and can be applied post hoc to any measured data set. Our evaluation finds that two of the methods are particularly effective. One of them estimates missing path samples by embedding the nodes in a low-dimensional coordinate space. For realistic sampling rates, the quality of its estimates for path latency approximates ideal, unbiased sampling. The other method is based on a view of network paths as being composed of source-specific, destination-specific, and shared components. It reduces bias for a wide range of path properties, such as latency, hop count and capacity. Applying Broom to data from a real measurement study leads to substantial changes in the resulting inferences. For some networks, the post-correction estimate is 30% higher than the original.
Design and technology for Collaborage (1999)

A Collaborage is a collaborative collage of physically represented information on a surface that is connected with electronic information, such as a physical In/Out board connected to a people-locator database. The physical surface (board) contains items that are tracked by camera and computer vision technology. Events on the board trigger electronic services. This paper motivates this concept, presents three different applications, describes the system architecture and component technologies, and discusses several design issues.
Ink‐Jet Printing of Binders for Ceramic Components (2002)

Layered manufacturing methods for fabricating ceramic components can involve selective deposition of binder using ink‐jet printing. Selection of a proper binder plays a critical role in fabricating parts with good surface finish, dimensional accuracy, and high resolution. Several polymeric solution‐phase binders were investigated in terms of their physical properties, printing performance, and binder‐powder bed interaction. It was observed that the molecular weight should be &lt;15 000 for the binder to be penetrated into dense powder compacts. Binder infiltration kinetics and printed line width were also significantly influenced by powder‐bed characteristics, such as surface roughness and pore size, as well as the physical properties of the binder, such as viscosity and surface tension.
Effect of chronic protein ingestion on tyrosine and tryptophan levels and catecholamine and serotonin synthesis in rat brain (2011)

The results indicate that the protein ingested can chronically modify TRP levels and serotonin synthesis in brain, but not TYR levels or catecholamine synthesis, with effects most distinct at an adequate level of protein intake (10%).
Si^+-implanted Si-wire waveguide photodetectors for the mid-infrared (2014)

CMOS-compatible Si⁺-implanted Si-waveguide p-i-n photodetectors operating at room temperature and at mid-infrared wavelengths from 2.2 to 2.3 µm are demonstrated. Responsivities of 9.9 ± 2.0 mA/W are measured at a 5 V reverse bias with an estimated internal quantum efficiency of 2.7 - 4.5%. The dark current is found to vary from a few microamps down to less than a nanoamp after a post-implantation annealing of 350°C. The measured photocurrent dependence on input power shows a linear correspondence over more than three decades, and the frequency response of a 250 µm-length p-i-n device is measured to be ~1.7 GHz for a wavelength of λ = 2.2 µm, thus potentially opening up new communication bands for photonic integrated circuits.