gebhart/patrepeval huggingface dataset:
Factors influencing lesion detection in medical imaging. (1990)

An important goal in medical imaging is the assessment of image quality in a way that relates to clinical efficacy. An objective approach is to evaluate the performance of diagnosis for specific tasks, using ROC analysis. We shall concentrate here on classification tasks. While many factors may confine the performance achieved for these tasks, we shall investigate two main limiting factors: image blurring and object variability. Psychophysical studies followed by ROC analysis are widely used for system assessment, but it is of great practical interest to be able to predict the outcome of psychophysical studies, especially for system design and optimization. The ideal observer is often chosen as a standard of comparison for the human observer since, at least for simple tasks, its performance can be readily calculated using statistical decision theory. We already know, however, of cases reported in the literature where the human observer performs far below ideal, and one of the purposes of this dissertation is to determine whether there are other practical circumstances where human and ideal performances diverge. Moreover, when the complexity of the task increases, the ideal observer becomes quickly intractable, and other observers such as the Hotelling and the nonprewhitening (npw) ideal observers may be considered instead. A practical problem where our intuition tells us that the ideal observer may fail to predict human performance occurs with imaging devices that are characterized by a PSF having long spatial tails. The investigation of the impact of long-tailed PSFs on detection is of great interest since they are commonly encountered in medical imaging and even more generally in image science. We shall show that the ideal observer is a poor predictor of human performance for a simple two-hypothesis detection task and that linear filtering of the images does indeed help the human observer. Another practical problem of considerable interest is the effect of background nonuniformity on detectability since, it is one more step towards assessing image quality for real clinical images. When the background is known exactly (BKE), the Hotelling and the npw ideal observers predict that detection is optimal for an infinite aperture; a spatially varying background (SVB) results in an optimum aperture size. Moreover, given a fixed aperture size and a BKE, an increase in exposure time is highly beneficial for both observers. For SVB, on the other hand, the Hotelling observer benefits from an increases in exposure time, while the npw ideal observer quickly saturates. In terms of human performance, results show a good agreement with the Hotelling-observer predictions, while the performance disagrees strongly with the npw ideal observer.
What Are the Migration Patterns for U.S. Primary Total Joint Arthroplasty Patients? (2019)

Level III, therapeutic study.
Repeatability of automated leakage quantification and microaneurysm identification utilising an analysis platform for ultra-widefield fluorescein angiography (2019)

This automated algorithm demonstrated very strong intrastudy correlation between paired time points in the same phases of the angiogram for quantifying retinal vascular characteristics, MA count and leakage parameters in UWFA images. These findings suggest significant flexibility in the platform for consistency in evaluating metrics over time and is encouraging for longitudinal assessment opportunities.
Energy-Efficient Standby Mode Algorithms in Short-Range One-to-One Millimeter-Wave Communications (2014)

This paper proposes two energy-efficient standby mode algorithms in short-range one-to-one 60GHz millimeter-wave (mmWave) communications. Among the many usage scenarios for mmWave radio, file downloading from kiosk terminals or peer-to-peer sync service with portable terminals are of great interest. For these portable terminals, reducing power consumption of standby mode as well as keeping connection setup time short is important. Comparing the power consumption between frame transmission and reception in short-range one-to-one 60GHz mmWave, the power consumed for a frame reception may become larger than that for a frame transmission. The proposed two energy-efficient standby mode algorithms for one-to-one communications assure the connection setup time and take each terminal's different requirement for reduction of its power consumption into consideration. In the proposed algorithms, each terminal accesses asynchronously and operates based on an interval consisting of several sub-intervals. In one proposed algorithm (Prop 1), a terminal transmits a connection request frame (CREQ) once every sub-interval and the other terminal waits for the CREQ during one sub-interval per interval. Thus, Prop 1 reduces the power consumption for CREQ transmission. In the other proposed algorithm (Prop 2), a terminal selects one sub-interval randomly for each interval and transmits CREQs repeatedly during that sub-interval. The other terminal waits for a CREQ during this CREQ transmission period at every sub-interval. Prop 2 saves the power consumption for a CREQ reception. We evaluate the power consumption of standby mode and connection setup time for Prop 1 and Prop 2 by both numerical analysis and computer simulations. We show that the power consumption of the CREQ waiting terminal with the proposed algorithms is more than 10mW lower than that with the conventional algorithm. We also show that our numerical analysis of the proposed algorithms derives the optimum parameters and facilitates system design. Next, we implement Prop 2 in a fully-integrated CMOS transceiver chip-set with antenna, RF/analog, PHY, and MAC for 60GHz proximity wireless communication. This experimental result is the same as the analysis result and it is verified that our proposed standby algorithm works as designed.
Image representation using mollified pixels for iterative reconstruction in x-ray CT (2012)

We introduce a new basis function, the mollified pixel, for image representation in X-ray computed tomography and other imaging modalities. The mollified pixel is defined as the convolution of a classical pixel with a smooth function that approximates the Dirac impulse. Since such a smooth function can be defined in an infinite number of ways, the mollified pixel defines a wide class of methods for image representation. For utilization of the mollified pixel in iterative reconstruction, it is needed to know the Radon transform of a mollified pixel. Using a link between classical pixels and B-splines, we suggest a computationally-efficient expression for this Radon transform. Preliminary iterative CT reconstruction results based on mollified pixels are provided along with our theoretical developments to demonstrate the potential benefits of mollified pixels.
Reducing the Effective Coupling Capacitance in Buses Using Threshold Voltage Adjustment Techniques (2006)

This paper proposes a bus architecture which improves the performance and/or power dissipation of online buses. The proposed architecture reduces the delay on alternate lines by lowering the threshold voltage of its devices. Furthermore, the shifting of the signal switching on adjacent lines reduces the worst case coupling capacitance. Two implementations of this bus architecture are proposed, the alternate-V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> and the alternate forward body biased schemes, and are compared to a conventional bus scheme. For a flop distance of 1800 mum, the proposed schemes use the gained delay slack to reduce the total device width, and thus reducing the energy dissipation by 31.2%. For a 500-ps cycle time, the proposed bus schemes increase the maximum distance between flip-flops by 33%
Lipid Rafts and Caveolin-1 Coordinate Interleukin-1β (IL-1β)-dependent Activation of NFκB by Controlling Endocytosis of Nox2 and IL-1β Receptor 1 from the Plasma Membrane (2009)

Recent evidence suggests that signaling by the proinflammatory cytokine interleukin-1beta (IL-1beta) is dependent on reactive oxygen species derived from NADPH oxidase. Redox signaling in response to IL-1beta is known to require endocytosis of its cognate receptor (IL-1R1) following ligand binding and the formation of redox-active signaling endosomes that contain Nox2 (also called redoxosomes). The consequent generation of reactive oxygen species by redoxosomes is responsible for the downstream recruitment of IL-1R1 effectors (IRAK, TRAF6, and IkappaB kinase kinases) and ultimately for activation of the transcription factor NFkappaB. Despite this knowledge of the signaling events that occur downstream of redoxosome formation, an understanding of the mechanisms that coordinate the genesis of redoxosomes following IL-1beta stimulation has been lacking. Here, we demonstrate that lipid rafts play an important role in this process. We show that Nox2 and IL-1R1 localize to plasma membrane lipid rafts in the unstimulated state and that IL-1beta signals caveolin-1-dependent endocytosis of both proteins into the redoxosome. We also show that inhibiting lipid raft-mediated endocytosis prevents NFkappaB activation. Finally, we demonstrate that Vav1, a Rac1 guanine exchange factor and activator of Nox2, is recruited to lipid rafts following IL-1beta stimulation and that it is required for NFkappaB activation. Our results fill in an important mechanistic gap in the understanding of early IL-1R1 and Nox2 signaling events that control NFkappaB activation, a redox-dependent process important in inflammation.
Copper‐Promoted/Catalyzed C—N and C—O Bond Cross‐Coupling with Vinylboronic Acid and Its Utilities. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Familial Bartter's Syndrome (1982)

Two sisters were found to have Bartter's syndrome. Both had hypokalemia, hyperreninemia, normal BPs, and decreased pressor responses to angiotensin II. During a water diuresis, patient 1 had an abnormally low distal tubular fractional reabsorption of chloride initially, but this normalized after hypokalemia was corrected for one year. Patient 2 had no demonstrable defect in chloride transport. Hypokalemia in Bartter's syndrome may be caused by some hereditary mechanisms other than defective reabsorption of chloride in the distal tubules.
Complexity of stoquastic frustration-free Hamiltonians (2008)

We study several problems related to properties of non-negative matrices that arise at the boundary between quantum and classical probabilistic computation. Our results are twofold. First, we identify a large class of quantum Hamiltonians describing systems of qubits for which the adiabatic evolution can be efficiently simulated on a classical probabilistic computer. These are stoquastic local Hamiltonians with a "frustration free" ground-state. A Hamiltonian belongs to this class iff it can be represented as $H=\sum_a H_a$ where (1) every term $H_a$ acts non-trivially on a constant number of qubits, (2) every term $H_a$ has real non-positive off-diagonal matrix elements in the standard basis, and (3) the ground-state of $H$ is a ground-state of every term $H_a$. Secondly, we generalize the Cook-Levin theorem proving NP-completeness of the satisfiability problem to the complexity class MA -- a probabilistic analogue of NP. Specifically, we construct a quantum version of the k-SAT problem which we call "stoquastic k-SAT" such that stoquastic k-SAT is contained in MA for any constant $k$, and any promise problem in MA is Karp-reducible to stoquastic 6-SAT. This result provides the first non-trivial example of a MA-complete promise problem.
Thermal control structure and garment (2023)

A flexible thermally conductive structure. The structure generally includes a plurality of thermally conductive yarns, at least some of which are at least partially disposed adjacent to an elastomeric material. Typically, at least a portion of the plurality of thermally conductive yarns is configured as a sheet. The yarns may be constructed from graphite, metal, or similar materials. The elastomeric material may be formed from urethane or silicone foam that is at least partially collapsed, or from a similar material. A thermal management garment is provided, the garment incorporating a flexible thermally conductive structure.
Evidence of a dynamic role of the target cell membrane during the early stages of the natural killer cell lethal hit. (1984)

The role of membrane movement during the stages of human NK cytolysis has been examined by using the bifunctional protein cross-linking reagent, glutaraldehyde. The binding stage was inhibited when K562 target cells or NK cells were pretreated with glutaraldehyde. When added post-binding, after initiation of calcium pulse, glutaraldehyde did not dissociate conjugates, but inhibited NK cytolysis. In contrast to the early stages of NK cytolysis, glutaraldehyde enhanced lysis during the terminal stage, killer cell independent lysis ( KCIL ). Lysis of the preprogrammed target cells, however, was enhanced only when glutaraldehyde was added immediately after dispersion of the conjugates, before target cell lysis. The mechanism of enhancement of lysis during the terminal stages of cytolysis was further explored in assays for NK cell-derived cytolytic factor (NKCF). L929 target cells prebound with NKCF were lysed more readily in the presence of glutaraldehyde, but as in KCIL , maximum enhancement of lysis occurred when glutaraldehyde was added immediately after NKCF was bound to the target cell. These results suggest that the target cell membrane may play a dynamic role during the terminal stages of the NK lethal hit.
Design of a 5kW, 1U, 10kW/ltr. resonant DC-DC converter for telecom applications (2007)

The demand for decreasing cost and volume and also for increasing efficiency leads to a constantly increasing power density of converter systems. For maximising the power density of a 5 kW telecom supply an optimisation procedure that automatically balances the switching frequency, semiconductor and passive losses, and thermal performance has been developed. This procedure and the belonging analytical converter and transformer models are presented in this paper. Moreover, the resulting optimised design, which has a power density of 10 kW/ltr. and an efficiency of 96% at a height of 1 U, is presented.
Merging Late-Stage Diversification with Solid-Phase Peptide Synthesis Enabled by High-Throughput On-Resin Reaction Screening (2022)

An integrated workflow is described that combines micromole-scale high-throughput experimentation (HTE) reaction screening and solid-phase peptide synthesis (SPPS) to enable rapid synthetic method development for on-resin peptide diversification. Using this new approach, we have identified several sets of robust Suzuki–Miyaura coupling conditions with complementary scope that collectively display broad coverage with respect to both resin-bound peptide substrates containing aryl halide side chains and (hetero)arylboronic acid coupling partners. We have also demonstrated the utility of this integrated SPPS/chemical diversification method by synthesizing a multidimensional library of diverse peptides in high yields.
Point Cloud Completion Guided by Prior Knowledge via Causal Inference (2023)

Point cloud completion aims to recover raw point clouds captured by scanners from partial observations caused by occlusion and limited view angles. This makes it hard to recover details because the global feature is unlikely to capture the full details of all missing parts. In this paper, we propose a novel approach to point cloud completion task called Point-PC, which uses a memory network to retrieve shape priors and designs a causal inference model to filter missing shape information as supplemental geometric information to aid point cloud completion. Specifically, we propose a memory operating mechanism where the complete shape features and the corresponding shapes are stored in the form of ``key-value'' pairs. To retrieve similar shapes from the partial input, we also apply a contrastive learning-based pre-training scheme to transfer the features of incomplete shapes into the domain of complete shape features. Experimental results on the ShapeNet-55, PCN, and KITTI datasets demonstrate that Point-PC outperforms the state-of-the-art methods.
Preparation and thermal decomposition of platinum(II) metallocycles (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and thermal decomposition of platinum(II) metallocyclesJoseph X. McDermott, John F. White, and George M. WhitesidesCite this: J. Am. Chem. Soc. 1973, 95, 13, 4451–4452Publication Date (Print):June 27, 1973Publication History Published online1 May 2002Published inissue 27 June 1973https://pubs.acs.org/doi/10.1021/ja00794a068https://doi.org/10.1021/ja00794a068research-articleACS PublicationsRequest reuse permissionsArticle Views434Altmetric-Citations110LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Thermal Oxidation of Sputter‐Coated Reaction‐Bonded Silicon Nitride (1984)

Ceramic coatings prepared by sputtering and reactive sputtering were applied to reaction‐bonded silicon nitride surfaces to prevent extensive oxidation of the underlying material. The high‐density nitride‐based coatings retard the oxidation of the substrate by forming an oxygen diffusion barrier which seals the open porosity while maintaining dimensional and thermal stability. The oxidation kinetics of the coated and uncoated reaction‐bonded silicon nitride substrates were compared at T = 1000 ° to 1200°C. Oxidation of the underlying material in this temperature range was substantially reduced when suitable coatings were used and the crystalline oxidation product (cristobalite) was essentially eliminated.
Proximal tubules from caspase-1-deficient mice are protected against hypoxia-induced membrane injury (2007)

These studies demonstrate a deleterious effect of the proinflammatory caspase, caspase-1, on PT in vitro in the absence of inflammatory cells and vascular effects.
Design strategies and rigorous conditions for single-polarization single-mode waveguides (2008)

We establish rigorous necessary analytical conditions for the existence of single-polarization single-mode (SPSM) bandwidths in index-guided microstructured waveguides (such as photonic-crystal fibers). These conditions allow us to categorize designs for SPSM waveguides into four strategies, at least one of which seems previously unexplored. Conversely, we obtain rigorous sufficient conditions for the existence of two cutoff-free index-guided modes in a wide variety of microstructured dielectric waveguides with arbitrary periodic claddings, based on the existence of a degenerate fundamental mode of the cladding (a degenerate light line). We show how such a degenerate light line, in turn, follows from the symmetry of the cladding.
Table S2 from Cancer-Associated Fibroblasts Promote Immunosuppression by Inducing ROS-Generating Monocytic MDSCs in Lung Squamous Cell Carcinoma (2023)

&lt;p&gt;Supplementary table 2&lt;/p&gt;
ACOUSTIC CAVITATION AND MEDICAL ULTRASOUND (2006)

The acoustic pressure amplitudes common to medical ultrasound devices are often significantly in excess of the cavitation threshold. For example, negative pressure amplitudes in excess of 15 MPa are used in a variety of therapeutic ultrasound devices such as those used in shock wave lithotripsy and high intensity focused ultrasound (HIFU) surgery; accordingly, cavitation is a common occurrence in the utilization of these devices. In some cases, this cavitation can be useful, if not essential, such as in the comminution of kidney stones by the intense shock waves used in lithotripsy. However, if the cavitation is not controlled, then these gas-filled cavities can act as a highly reflective barrier against further acoustic propagation. We have determined, for example, that there is a maximum pulse repetition rate for shock wave lithotripsy. When HIFU therapy systems are used for tumor necrosis, the acoustic intensities can achieve levels in excess of several kilowatts/cm 2 . With these intensities, cavitation can readily be achieved, even in the high-threshold, high-frequency realm of medical ultrasound. Because the ultimate goal of a HIFU therapy system is to necrose tissue, the appearance of cavitation was previously thought to be undesirable; however, in some cases, the initiation of cavitation can lead to enhanced heating, and also to protocols that prevent collateral eects of HIFU. In this presentation, a review of the occurrence of cavitation in medical ultrasound applications will be presented as well as some recent experimental results.
Preliminary testing and evaluation of the renata minima stent, an infant stent capable of achieving adult dimensions (2021)

In this in vivo study of the Minima stent, there was high implant success, predictable re-dilatability to adult diameters and favorable histopathology. Further study is warranted.
Abstract 3091: A sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis (2012)

Abstract Myc is an oncogenic transcription factor frequently dysregulated in human malignancies. While the transcriptional programs and other functions of Myc have been intensively studied, there remains no effective strategy for inhibiting Myc in patients. To search for pathways that support the Myc oncogenic program, we employed a next-generation RNAi screen for Myc-synthetic lethal (MySL) genes. Using this strategy, we have identified several cellular processes required to tolerate oncogenic Myc. Key among these is the core sumoylation machinery, and we define the Sumo-activating enzyme (SAE) as a central component in this MySL network. Loss of SAE drives synthetic lethality with Myc, and the enzymatic activity of SAE is required to support the Myc oncogenic state. Inactivation of SAE leads to mitotic catastrophe and cell death selectively upon Myc hyper-activation. Mechanistically, depletion of SAE switches a subprogram of Myc transcriptional targets governing mitotic spindle function from activated to repressed, a subprogram we term Sumoylation-dependent Myc Switchers, or SMS genes. Notably, SMS genes are required to tolerate Myc hyper-activation, and SAE and the SMS program are required for Myc-dependent breast cancer cell survival in vitro and tumor growth and progression in vivo. Importantly, patient survival significantly correlates with levels of SAE and SMS gene expression in Myc-high tumors. Collectively, these studies reveal a mitotic vulnerability of Myc-driven cancers and demonstrate that inhibiting sumoylation can selectively impair mitosis and survival in an oncogenic Myc-dependent manner. We propose that drugs targeting SAE and its downstream SMS targets may have therapeutic benefits for patients with Myc-driven cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3091. doi:1538-7445.AM2012-3091