gebhart/patrepeval huggingface dataset:
Tracking of an Oral Salmonella-Based Vaccine for Type 1 Diabetes in Non-obese Diabetic Mice (2020)

Type 1 diabetes (T1D) arises secondary to immune-driven destruction of pancreatic β-cells and manifests as insulin-deficient hyperglycemia. We showed that oral vaccination with live attenuated <i>Salmonella</i>, which simultaneously delivers autoantigens and a TGFβ expression vector to immune cells in the gut mucosa, provides protection against the progression of T1D in non-obese diabetic (NOD) mice. In this study we employed the Sleeping Beauty (SB) transposon system that is composed of a transposase and transposon encoding the td-Tomato to express red fluorescent protein (RFP) to permanently mark the cells that take up the <i>Salmonella</i> vaccine. After animal vaccination, the transposon labeled-dendritic cells (DCs) with red fluorescence appeared throughout the secondary lymphoid tissues. Furthermore, Sleeping Beauty containing <i>tgf</i>β<i>1</i> gene (SB-tgfβ1) co-expressed TGFβ and RFP. The labeled DCs were detected predominantly in Peyer's patches (PP) and mesenteric lymph nodes (MLN) and expressed CD103 surface marker. CD103<sup>+</sup> DCs induced tolerogenic effects and gut homing. TGFβ significantly increased programmed death-ligand-1 (PDL-1 or CD274) expression in the DCs in the MLN and PP of treated mice. Also, TGFβ increased cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) levels in CD4<sup>+</sup> cells in MLN and PP. Interestingly, DCs increased in all lymphatic organs of mice vaccinated with oral live <i>Salmonella</i>-based vaccine expressing preproinsulin (PPI), in combination with TGFβ, IL10, and subtherapeutic-doses of anti-CD3 mAb compared with vehicle-treated mice. These DCs are mostly tolerogenic in MLN and PP. Furthermore the DCs obtained from vaccine-treated but not vehicle-treated mice suppressed <i>in vitro</i> T cell proliferation. These data suggest that the MLN and the PP are a central hub for the beneficial anti-diabetic effects of an oral <i>Salmonella</i>-based vaccine prevention of diabetes in rodents.
Efficient self-seeding of a pulsed Ti^3+:Al_2O_3 laser (1998)

We describe the design considerations and operating characteristics of a compact, widely tunable, narrow-linewidth, megawatt-class pulsed laser system based on Ti3+:Al2O3 (Ti:sapphire) pumped by the second harmonic of a 1.06?µm Nd:YAG laser. The system delivers 10 mJ in a 5-ns near-transform-limited single-longitudinal-mode (SLM) pulse with a threshold of 20 mJ and a slope efficiency greater than 40%. By the technique of self-seeding, in which a portion of the gain medium’s spontaneous fluorescence is coupled back to the laser cavity, SLM operation may be obtained across the entire gain profile of Ti:sapphire with a minimum number of optical components and without external seeding.
IKZF1 alterations predict poor prognosis in adult and pediatric T-ALL (2020)

Patient outcomes in T-cell acute lymphoblastic leukemia and lymphoblastic lymphoma (T-ALL/LBL) can be difficult to predict. Simonin et al report deletions and mutations in the gene encoding the transcription factor IKAROS among 1260 children and adults with immature T-ALL/LBL, defining its frequency and, importantly, its association with poor outcome in multivariate models. Pathogenic alterations in IKZF1 now can be added to minimal residual disease detection and the established 4-gene oncogenetic classifier to better predict poor outcomes of T-ALL/LBL.
Principles For Designing Computer Music Controllers (2001)

This paper will present observations on the design, artistic, and human factors of creating digital music controllers. Specific projects will be presented, and a set of design principles will be supported from those examples.
Decreasing Bacterial Colonization of External Fixation Pins Through Nitric Oxide Release Coatings (2011)

The application of NO-releasing xerogel coatings can inhibit bacterial colonization of external fixation pins both during the initial postsurgical period and up to 48 days postimplantation.
Recipients of Vaccine against the 1976 “Swine Flu” Have Enhanced Neutralization Responses to the 2009 Novel H1N1 Influenza Virus (2010)

BACKGROUND. The world is facing a novel H1N1 influenza pandemic. A pandemic scare with a similar influenza virus in 1976 resulted in the vaccination of nearly 45 million persons. We hypothesized that prior receipt of the 1976 "swine flu" vaccine would enhance immune responses to the 2009 novel H1N1 influenza strain. METHODS. A prospective, volunteer sample of employees aged > or = 55 years at a children's cancer hospital in August 2009 was assessed for antibody responses to the 2009 pandemic H1N1 influenza virus and the 2008-2009 seasonal H1N1 influenza virus. RESULTS. Antibody responses by hemagglutination-inhibition assay were high against both the seasonal influenza virus (89.7% had a titer considered seroprotective) and pandemic H1N1 influenza virus (88.8% had a seroprotective titer). These antibodies were effective at neutralizing the seasonal H1N1 influenza virus in 68.1% of participants (titer > or = 40), but only 18.1% had detectable neutralizing titers against the pandemic H1N1 influenza virus. Of 116 participants, 46 (39.7%) received the 1976 "swine flu" vaccine. Receipt of this vaccine significantly enhanced neutralization responses; 8 (17.4%) of 46 vaccine recipients had titers > or = 160, compared with only 3 (4.3%) of 70 who did not receive the vaccine (P = .018 by chi(2) test). CONCLUSIONS. In this cohort, persons aged > or = 55 years had evidence of robust immunity to the 2008-2009 seasonal H1N1 influenza virus. These antibodies were cross-reactive but nonneutralizing against the 2009 pandemic H1N1 influenza strain. Receipt of a vaccine to a related virus significantly enhanced the neutralization capacity of these responses, suggesting homologous vaccination against the 2009 pandemic H1N1 influenza virus would have a similar effect.
Decays of New Nuclides and Isomers Beyond the Proton Drip Line—The Influence of Neutron Configurations (2008)

The energy of the vh9/2 orbital in nuclei above N = 82 drops rapidly in energy relative to the vf7/2 orbital as the occupancy of the πh11/2 orbital increases. These two neutron orbitals become nearly degenerate as the proton drip line is approached. In this work, we have discovered the new nuclides 161Os and 157W, and studied the decays of the proton emitter 160Re in detail. The 161Os and 160Re nuclei were produced in reactions of 290, 300 and 310 MeV 58Ni ions with an isotopically enriched 106Cd target, separated in‐flight using the RITU separator and implanted into the GREAT spectrometer. The 161Os α a decays populated the new nuclide 157W, which decayed by β‐particle emission. The β decay fed the known α‐decaying 1/2+ and 11/2− states in 157Ta, which is consistent with a vf7/2 ground state in 157W. The measured α‐decay energy and half‐life for 161Os correspond to a reduced α‐decay width that is compatible with s‐wave α‐particle emission, implying that its ground state is also a vf7/2 state. Over 7000 160Re nuclei were produced and the γ decays of a new isomeric state feeding the πd3/2 level in 160Re were discovered, but no evidence for the proton or a decay of the expected πh11/2 state could be found. The isomer decays offer a natural explanation for this non‐observation and provides a striking example of the influence of the near degeneracy of the vh9/2 and vf7/2 orbitals on the properties of nuclei in this region.
Whole‐body 3D water/fat resolved continuously moving table imaging (2007)

Whole-body water/fat sensitive MRI using continuous table motion is feasible and could be of interest for clinical practice. Some improvements of the method are desirable.
Reduced acoustic noise in diffusion tensor imaging on a compact MRI system (2017)

The feasibility of achieving reduced acoustic noise levels with whole-brain DTI on the C3T MRI was demonstrated. Magn Reson Med 79:2902-2911, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
What Is the Clinical Relevance of Radiographic Nonunion After Single-Level Lumbar Interbody Arthrodesis in Degenerative Disc Disease? (2015)

The presence of radiographic fusion is clinically significant, as patients with fusion had better clinical outcomes at 1 and 2 years postoperative than those with nonunion; however, patient-centered clinical outcomes should also be taken into consideration as independent, complimentary variables when assessing treatment success.
THz Artificial Dielectric Lens (2015)

We demonstrate a THz lens designed using an artificial-dielectric medium fabricated from a stack of stainless-steel plates. The lens is capable of focusing a 20 mm diameter beam to a spot size of 4 mm.
Analysis of the linear methods for determining copolymerization reactivity ratios. II. A critical reexamination of cationic monomer reactivity ratios (1975)

Abstract A thorough examination of some cationic copolymerization systems by a new method has shown that many published r values have to be corrected significantly and that some are erroneous and meaningless, because for these systems the conventional copolymer compositions equation does not hold. Available information in regard of cationic copolymerizations has been treated in terms of three classes: (a) Systems in which the conventional copolymer composition equation adequately describes the copolymerization mechanism and previous authors justifiably used the two parameter model to calculate reactivity ratios. Our results show that the discrepancy between published r values and the more precise values obtained in this work is about ±23%. (b) Systems in which the approximations implicit in the conventional copolymer composition equation do not hold and the calculated r values are erroneous and misleading. Monomer pairs comprising monomers of significantly different reactivities belong to this class indicating that in copolymerizations in general and in cationic copolymerizations in particular a strong cast system exists, i.e., copolymerization can readily occur within the cast (between monomers of similar reactivities); however, only with difficulty if at all between casts (between monomers of differing reactivities). (c) Systems in which the use of the copolymer composition equation is completely unjustified, the calculated r values are meaningless and in some cases the existence of true copolymers is questioned.
Miniature reaction chamber and devices incorporating same (2023)

The present invention generally relates to miniaturized devices for carrying out and controlling chemical reactions and analyses. In particular, the present invention provides devices which have miniature temperature controlled reaction chambers for carrying out a variety of synthetic and diagnostic applications, such as PCR amplification, nucleic acid hybridization, chemical labeling, nucleic acid fragmentation and the like.
Workshop in green chemistry production of essential medicines in developing countries (2008)

Prof. O. O. Kunle, Prof. J. Fortunak and Prof. Robin D. Rogers report on the Workshop in green chemistry production of essential medicines in developing countries, held in Abuja, Nigeria from 18th–20th March, 2008.
Repetition-based dense single-view reconstruction (2011)

This paper presents a novel approach for dense reconstruction from a single-view of a repetitive scene structure. Given an image and its detected repetition regions, we model the shape recovery as the dense pixel correspondences within a single image. The correspondences are represented by an interval map that tells the distance of each pixel to its matched pixels within the single image. In order to obtain dense repetitive structures, we develop a new repetition constraint that penalizes the inconsistency between the repetition intervals of the dynamically corresponding pixel pairs. We deploy a graph-cut to balance between the high-level constraint of geometric repetition and the low-level constraints of photometric consistency and spatial smoothness. We demonstrate the accurate reconstruction of dense 3D repetitive structures through a variety of experiments, which prove the robustness of our approach to outliers such as structure variations, illumination changes, and occlusions.
Camera-based heart rate monitoring in highly dynamic light conditions (2013)

Recent advances in biomedical engineering have shown that heart rate can be monitored remotely using regular RGB cameras by analyzing minute skin color changes caused by periodic blood flow. In this paper an infrared-based alternative for light-robust camera-based heart rate measurements suitable for automotive applications is presented. The results obtained by this system show high accuracy (RMSE <; 1BPM under discolight) and a correlation score above 0.99 when compared with a reference measurement method. The proposed system enables new applications in the automotive field, especially since heart rate measurement can be integrated with other camera-based driver monitoring solutions like eye tracking.
Identification and functional analysis of fructosyl amino acid-binding protein from Gram-positive bacteriumArthrobactersp. (2013)

The novel FABP exhibits the ability to specifically bind to Nα-FA with a high affinity. This selectivity is beneficial for applying FABP in HbA1c sensing. The successful preparation of water-soluble, functionally expressed Gram-negative bacterial FABP may make way for future applications for a variety of SBPs from Gram-positive bacteria employing the same expression strategy. The results obtained here enhance our understanding of bacterial FA catabolism and contribute to the improved development of FABP as Nα-FA-sensing molecules.
An intelligent video framework for homeland protection (2007)

This paper presents an overview of Intelligent Video work currently under development at the GE Global Research Center and other research institutes. The image formation process is discussed in terms of illumination, methods for automatic camera calibration and lessons learned from machine vision. A variety of approaches for person detection are presented. Crowd segmentation methods enabling the tracking of individuals through dense environments such as retail and mass transit sites are discussed. It is shown how signature generation based on gross appearance can be used to reacquire targets as they leave and enter disjoint fields of view. Camera calibration information is used to further constrain the detection of people and to synthesize a top-view, which fuses all camera views into a composite representation. It is shown how site-wide tracking can be performed in this unified framework. Human faces are an important feature as both a biometric identifier and as a method for determining the focus of attention via head pose estimation. It is shown how automatic pan-tilt- zoom control; active shape/appearance models and super-resolution methods can be used to enhance the face capture and analysis problem. A discussion of additional features that can be used for inferring intent is given. These include body-part motion cues and physiological phenomena such as thermal images of the face.
Dynamics and Periodicity Based Multirate Fast Transient-Sound Detection (2018)

This paper proposes an efficient real-time multirate fast transient-sound detection algorithm on the basis of emerging microphone array configuration intended for multimedia signal processing application systems such as digital smart home. The proposed detection algorithm first extracts the dynamics and periodicity features, then trains the model parameters of these features on Amazon machine learning platform. The real-time testing results have shown that the proposed algorithm with the trained model parameters can not only achieve the optimum detection performance in all various noisy conditions but also reject all kinds of interferences including undesired voice and other unrelated transient-sounds. In comparison with the existing algorithms, the proposed detection algorithm significantly improves the false negative and false positive performance. In addition, the proposed multirate strategy dramatically reduces the computational complexity and processing latency so that the proposed algorithm can serve as a much more practical solution for the digital smart home related applications.
Role of Hydroxyl Radicals and Mechanism of Escherichia coli Inactivation on Ag/AgBr/TiO2 Nanotube Array Electrode under Visible Light Irradiation (2012)

A ternary Ag/AgBr/TiO(2) nanotube array electrode with enhanced visible-light activity was synthesized by a two-step approach including electrochemical process of anodization and an in situ photoassisted deposition strategy. The dramatically enhanced photoelectrocatalytic activity of the composite electrode was evaluated via the inactivation of Escherichia coli under visible light irradiation (λ>420 nm), whose performance of complete sterilization was much superior to other reference photocatalysts. PL, ESR, and radicals trapping studies revealed hydroxyl radicals were involved as the main active oxygen species in the photoelectrocatalytic reaction. The process of the damage of the cell wall and the cell membrane was directly observed by ESEM, TEM, and FTIR, as well as further confirmed by determination of potassium ion leakage from the killed bacteria. The present results pointed to oxidative attack from the exterior to the interior of the Escherichia coli by OH(•), O(2)(•-), holes and Br(0), causing the cell to die as the primary mechanism of photoelectrocatalytic inactivation.
ChemInform Abstract: Synthesis and Structure‐Activity Relationship of (Lactamylvinyl) cephalosporins Exhibiting Activity Against Staphylococci, Pneumococci, and Enterococci. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay (2021)

Interpretation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serosurveillance studies is limited by poorly defined performance of antibody assays over time in individuals with different clinical presentations. We measured antibody responses in plasma samples from 128 individuals over 160 days using 14 assays. We found a consistent and strong effect of disease severity on antibody magnitude, driven by fever, cough, hospitalization, and oxygen requirement. Responses to spike protein versus nucleocapsid had consistently higher correlation with neutralization. Assays varied substantially in sensitivity during early convalescence and time to seroreversion. Variability was dramatic for individuals with mild infection, who had consistently lower antibody titers, with sensitivities at 6 months ranging from 33 to 98% for commercial assays. Thus, the ability to detect previous infection by SARS-CoV-2 is highly dependent on infection severity, timing, and the assay used. These findings have important implications for the design and interpretation of SARS-CoV-2 serosurveillance studies.
Optimal beamforming using higher order statistics for passive acoustic mapping (2017)

Passive Acoustic Mapping (PAM) of sources of nonlinear acoustic emissions has been extensively investigated for monitoring ultrasound therapies. Optimal data-adaptive beamforming algorithms, such as Robust Capon Beamformer (RCB), were readily proposed as a means of improving source localization, accounting simultaneously for array configuration and calibration errors. RCB, however, assumes that signal samples follow a Gaussian distribution. Aiming at improving the spatial resolution of PAM, especially in the axial direction with respect to the array, we propose an alternative beamforming approach, Robust Beamforming by Linear Programming (RLPB). This method makes no assumptions on the statistical distribution of the received signals, and exploits not only the variance but also higher-order-statistics (HOS) of the received signals. Performance evaluation on simulated and in vitro experimental data suggests improvement in spatial resolution on the order of 20% and 15% in the axial and transverse directions respectively. This facilitates real-time mapping of disjoint cavitating regions over biologically relevant lengthscales on the order of 2 mm in the axial direction. It is expected that the proposed beamforming approach will provide the necessary improvement in PAM spatial resolution required in several clinically relevant situations, where a single array is used and the ratio of depth to aperture becomes large.
Overexpression of NAD(P)H:quinone Oxidoreductase 1 in Human Reproductive System (2001)

NAD(P)H:quinone oxidoreductase 1 (NQO1; DT-diaphorase; DTD) is a two-electron reductase that efficiently bioactivates compounds of the quinone family, such as mitomycin C. The observation that DTD is overexpressed in many cancerous tissues compared to normal tissues has provided us with a potentially selective target that can be exploited in the design of novel anticancer agents. Because of the relative lack of information on the cell-specific expression of DTD, the purpose of this study was to perform a body mapping of its normal distribution. Tissue samples from various components of the human reproductive system were analyzed by immunohistochemistry. We found strong expression of this enzyme in testicular stromal cells (Leydig cells) and in the epithelium of epididymis, ductuli efferentes, and Fallopian tube. These results suggest that DTD-bioactivated quinones could be responsible for a selective toxicity on these components of the reproductive system and cause clinical problems due to testosterone deficiency and infertility. This observation needs to be investigated in preclinical evaluation of new anticancer quinones and in patients treated with these compounds. (J Histochem Cytochem 49:1187-1188, 2001)
Sequence analysis of polymerase chain reaction amplified t(14;18) chromosomal breakpoints in formalin fixed, paraffin wax embedded follicular lymphoma. (1992)

The identification of junctional sequences of the translocation in follicular lymphoma provides a molecular "fingerprint" of t(14;18) of the lymphoma of an individual patient and can be used for the detection of clone specific DNA in any biopsy tissue obtained from the patient. The strategy used for rapid sequence analysis of PCR amplified DNA sequences will be useful in many areas of molecular pathology.
LAPAROSCOPIC TRANSUTERINE FETAL VESICOSTOMY: A FEASIBILITY STUDY (2004)

Although technically challenging, transuterine laparoscopic fetal vesicostomy is technically feasible in the ewe model. Continued evaluation of this technique should include intensive fetal monitoring and the use of tocolytics to decrease the incidence of spontaneous abortion.
Efficient Power Transfer via Induced Virtual Critical Coupling in an Overcoupled Silicon Nitride Microresonator (2023)

We induce virtual critical coupling in an overcoupled photonic microresonator using complex-frequency pulses. We observe efficient cavity storage as an incident pulse of time constant 138 ps suppresses the resonant transmission from 0.58 to 0.11.