gebhart/patrepeval huggingface dataset:
A Digital Twin for the 5G Era: the SPIDER Cyber Range (2022)

Service providers, 5G network operators and, more generally, vertical industries face today a dangerous shortage of highly skilled cybersecurity experts. Along with the escalation and growing sophistication of cyber-attacks, 5G networks require the training of skilled and highly competent cyber forces. To meet these requirements, the SPIDER cyber range focuses specifically on 5G, and is based on three pillars, (i) cyber security assessment, (ii) training cyber security teams to defend against complex cyber-attack scenarios, and (iii) evaluation of cyber risk.<br> The SPIDER cyber range replicates a customized 5G network, enabling the execution of cyber-exercises that take advantage of hands-on interaction in real time, the sharing of information between participants, and the gathering of feedback from network equipment, as well as the development and adaptation of advanced operational procedures. This aims to help 5G security professionals improve their ability to collaboratively manage and predict security incidents, complex attacks, and propagated vulnerabilities.<br> The SPIDER cyber range is validated in two relevant use case scenarios aimed at demonstrating, in a realistic, measurable, and replicable way the transformations SPIDER will bring to the cybersecurity industry.
ROI reconstruction of motion-contaminated data with a backprojection filtration algorithm (2006)

In order to evaluate the potential of using the backprojection filtration (BPF) algorithm for reconstructing images from motion-contaminated data, simulation studies were conducted with three virtual phantoms. The first was a uniform elliptical phantom, which underwent rotational motion during half of its temporal cycle. The second was a normal-sized modified FORBILD phantom with a dynamic insert undergoing contractile motion during 65% of its temporal cycle. This phantom was expanded to form a third phantom, whose portions extended beyond the field-of-view (FOV). For the elliptical phantom, the BPF algorithm was able to obtain an exact reconstruction of a region-of-interest (ROI) covering a portion of the ellipse, whereas the fanbeam filtered backprojection (FFBP) algorithm could not. For the normal-sized phantom, nine full-scan data sets were acquired with percents of motion-contaminated data PMCDs ranging from 17.5% to 100%. For each data set, the mean absolute difference MAD, root mean square error RMS, and correlation CORR metrics were used to assess the differences between a defined ROI reconstructed from motion-contaminated data from the same ROI reconstructed from motion-free data. The BPF algorithm using a reduced-scan interval was able to produce better MAD, RMS, and CORR metrics than both FFBP and BPF algorithms using the same short-scan interval over all PMCDs. For the expanded phantom, the presence of truncations in the data sets did not affect the overall trends of the three metrics in BPF reconstructions of eight data sets with PMCDs ranging from 15% to 100%.
Model experiment to study sonic boom propagation through turbulence. Part III: Validation of sonic boom propagation models (2002)

In previous papers, we have shown that model experiments are successful in simulating the propagation of sonic booms through the atmospheric turbulent boundary layer. The results from the model experiment, pressure wave forms of spark-produced N waves and turbulence characteristics of the plane jet, are used to test various sonic boom models for propagation through turbulence. Both wave form distortion models and rise time prediction models are tested. Pierce's model [A. D. Pierce, "Statistical theory of atmospheric turbulence effects on sonic boom rise times," J. Acoust. Soc. Am. 49, 906-924 (1971)] based on the wave front folding mechanism at a caustic yields an accurate prediction for the rise time of the mean wave form after propagation through the turbulence.
Keynote at SIES: Heterogeneous processors in SoC simplifies integration of IEC61508 and ISO26262 functional safety designs. The ZYNQ7000 experience (2016)

These keynotes discuss the following: Heterogeneous processors in SoC simplifies integration of IEC61508 and ISO26262 functional safety designs; What is happening to Cyber Physical Systems?; and Scalable (yet precise) Timing Verification of Embedded Software.
Intramolecular vibrational redistribution in electronically excited naphthalene (1979)

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Introduction to WCDMA enhanced uplink (2004)

In WCDMA, uplink radio resources are shared by multiple users and the radio resource management (RRM) is done at the UTRAN (UMTS Terrestrial Radio Access Network). In this paper, the link and system performance of the WCDMA uplink is evaluated using different techniques such as retransmissions with incremental redundancy (IR), short frame durations and fast scheduling. It is seen that the radio link efficiency can be improved using IR, while the traffic delays can be reduced and cell throughput can be enhanced by using fast scheduling and short frame durations.
Photochemical cyclization of 4-methallyl-4-methylcyclopentenone. 220 MHz nuclear magnetic resonance spectra of tricyclo[3.3.0.02,7]octanes (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemical cyclization of 4-methallyl-4-methylcyclopentenone. 220 MHz nuclear magnetic resonance spectra of tricyclo[3.3.0.02,7]octanesSteven Wolff, Semiramis Ayral-Kaloustian, and William C. AgostaCite this: J. Org. Chem. 1976, 41, 18, 2947–2950Publication Date (Print):September 1, 1976Publication History Published online1 May 2002Published inissue 1 September 1976https://pubs.acs.org/doi/10.1021/jo00880a002https://doi.org/10.1021/jo00880a002research-articleACS PublicationsRequest reuse permissionsArticle Views44Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Therapeutic Efficacy and Safety of Paclitaxel/Lonidamine Loaded EGFR-Targeted Nanoparticles for the Treatment of Multi-Drug Resistant Cancer (2011)

The treatment of multi-drug resistant (MDR) cancer is a clinical challenge. Many MDR cells over-express epidermal growth factor receptor (EGFR). We exploit this expression through the development of EGFR-targeted, polymer blend nanocarriers for the treatment of MDR cancer using paclitaxel (a common chemotherapeutic agent) and lonidamine (an experimental drug; mitochondrial hexokinase 2 inhibitor). An orthotopic model of MDR human breast cancer was developed in nude mice and used to evaluate the safety and efficacy of nanoparticle treatment. The efficacy parameters included tumor volume measurements from day 0 through 28 days post-treatment, terminal tumor weight measurements, tumor density and morphology assessment through hematoxylin and eosin staining of excised tumors, and immunohistochemistry of tumor sections for MDR protein markers (P-glycoprotein, Hypoxia Inducible Factor, EGFR, Hexokinase 2, and Stem Cell Factor). Toxicity was assessed by tracking changes in animal body weight from day 0 through 28 days post-treatment, by measuring plasma levels of the liver enzymes ALT (Alanine Aminotransferase) and LDH (lactate dehydrogenase), and by white blood cell and platelet counts. In these studies, this nanocarrier system demonstrated superior efficacy relative to combination (paclitaxel/lonidamine) drug solution and single agent treatments in nanoparticle and solution form. The combination nanoparticles were the only treatment group that decreased tumor volume, sustaining this decrease until the 28 day time point. In addition, treatment with the EGFR-targeted lonidamine/paclitaxel nanoparticles decreased tumor density and altered the MDR phenotype of the tumor xenografts. These EGFR-targeted combination nanoparticles were considerably less toxic than solution treatments. Due to the flexible design and simple conjugation chemistry, this nanocarrier system could be used as a platform for the development of other MDR cancer therapies; the use of this system for EGFR-targeted, combination paclitaxel/lonidamine therapy is an advance in personalized medicine.
Characterization of waveguide and grating formation in As/sub 2/S/sub 3/ (2002)

Photodarkening in the chalcogenide glass As/sub 2/S/sub 3/ makes it attractive for applications in integrated optics and data storage. Various optical devices can be fabricated using the laser-induced change of refractive index in this material. Waveguides, directional couplers, and holographic gratings have been fabricated on thin films and bulk samples of As/sub 2/S/sub 3/. This paper reports studies of the dynamics of waveguide and grating formation on the surface of bulk As/sub 2/S/sub 3/. Spatial and temporal characteristics of laser-induced refractive index changes are described. Several different materials effects are shown to contribute to the index modulation.
Investigation of Leaf Essential Oil ofMyrica galeL. from Quebec: Purification and Analysis of Oxygenated Fractions (2006)

Abstract The leaf essential oil of Myrica gale L. was isolated by hydrodistillation. The chemical composition of the whole oil was determined by GC and GC/MS analyses. We identified 48 components and eudesm-11-en-4-ol (11.5%), myrcene (11.3%), β-caryophyllene (8.4%) and α-phellandrene (7.1%) were the major compounds. Many oxygenated components could not be immediately identified in this whole oil. Thus, fractionation of the leaf oil of M. gale by high pressure flash chromatography yielded four fractions that were analyzed by GC and GC/MS. Fraction 1 was a terpene hydrocarbon fraction, whereas fractions 2 and 3 were mainly composed of oxygenated compounds except alcohols. Germacrone (46.3%) was the major constituent in fraction 2 whereas caryophyllene oxide (44.8%) and humulene epoxide II (22.1%) were predominant in fraction 3. The fourth fraction contained exclusively alcohols with selin-11-en-4α-ol (78.6%) as the major component.
Pharmacogenomic Markers of Metoprolol and α-OH-Metoprolol Concentrations: A Genome-Wide Association Study (2023)

<b>Aim:</b> Few genome-wide association studies (GWASs) have been conducted to identify predictors of drug concentrations. The authors therefore sought to discover the pharmacogenomic markers involved in metoprolol pharmacokinetics. <b>Patients & methods:</b> The authors performed a GWAS of a cross-sectional study of 993 patients from the Montreal Heart Institute Biobank taking metoprolol. <b>Results:</b> A total of 391 and 444 SNPs reached the significance threshold of 5 × 10<sup>-8</sup> for metoprolol and α-OH-metoprolol concentrations, respectively. All were located on chromosome 22 at or near the <i>CYP2D6</i> gene, encoding CYP450 2D6, metoprolol's main metabolizing enzyme. <b>Conclusion:</b> The results reinforce previous findings of the importance of the <i>CYP2D6</i> locus for metoprolol concentrations and confirm that large biobanks can be used to identify genetic determinants of drug pharmacokinetics at a GWAS significance level.
MOCVD Routes to Tl2Ba2Can-1CunO4+2nSuperconductor and Dielectric Insulator Thin Films (1995)

The evolution of HTS device technologies will benefit from the development of MOCVD (Metal-organic Chemical Vapor Deposition) routes to high quality HTS films as well as to those of insulators with low dielectric loss and close HTS lattice matches. Reviewed here are research efforts at precursor design focusing on Ba sources. A novel low pressure TGA technique is used to compare volatilities of MOCVD precursors and to quantify the role of gas phase diffusion in film growth. To form high quality Tl2Ba2Can-1CunO4+2n (n = 2.3) films. BaCaCuO(F) films are first deposited by MOCVD using the liquid precursors Ba(hfa)2[MATH]mep, Ca(hfa)2[MATH]tet, and solid Cu(dpm)2 (hfa = hexafluoroacetylacetonate, dpm = dipivaloylmethanate. mep = methylethylpentaglyme, tet = tetraglyme). The film growth psocess is shown to be mass transport-limited, and an interesting ligand exchange process is identified. The superconducting TBCCO phase is formed following an ex-situ anneal in the presence of Tl2O at temperatures from 820-900°C. Transport properties of TBCCO-2223 films include a Tc as high as 115K. Jc of 2x105 A/cm2 (77K), and Rs of 0.35m[MATH] (5K, 10 GHz). The MOCVD growth of low loss, lattice-matched dielectric NdGaO3, PrGaO3, Sr2AlTaO6, and SrPrGaO4 films is also discussed. High quality YBa2Cu3O7-x films have been grown upon MOCVD-derived PrGaO3 substrates.
ABCB5-Targeted Chemoresistance Reversal Inhibits Merkel Cell Carcinoma Growth (2016)

Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer with profound but poorly understood resistance to chemotherapy, which poses a significant barrier to clinical MCC treatment. Here we show that ATP-binding cassette member B5 (ABCB5) confers resistance to standard-of-care MCC chemotherapeutic agents and provide proof-of-principle that ABCB5 blockade can inhibit human MCC tumor growth through sensitization to drug-induced cell cytotoxicity. ABCB5 expression was detected in both established MCC lines and clinical MCC specimens at levels significantly higher than those in normal skin. Carboplatin- and etoposide-resistant MCC cell lines exhibited increased expression of ABCB5, along with enhanced ABCB1 and ABCC3 transcript expression. ABCB5-expressing MCC cells in heterogeneous cancers preferentially survived treatment with carboplatin and etoposide in vitro and in human MCC xenograft-bearing mice in vivo. Moreover, patients with MCC also exhibited enhanced ABCB5 positivity after carboplatin- and etoposide-based chemotherapy, pointing to clinical significance of this chemoresistance mechanism. Importantly, ABCB5 blockade reversed MCC drug resistance and impaired tumor growth in xenotransplantation models in vivo. Our results establish ABCB5 as a chemoresistance mechanism in MCC and suggest utility of this molecular target for improved MCC therapy.
Differential response of embryonic and fetal myoblasts to TGFβ: a possible regulatory mechanism of skeletal muscle histogenesis (1994)

Embryonic and fetal skeletal myoblasts were grown in culture in the presence of TGF beta. Under the conditions employed, TGF beta inhibited differentiation of fetal but not of embryonic myoblasts. To investigate the possible relevance of these data to skeletal muscle histogenesis in vivo, we studied the proliferation/differentiation state of mesodermal cells in the proximal region of the limb bud at the time of primary fiber formation. BrdU labeling and immunostaining for myosin heavy chains revealed that very few mesodermal cells enter the S phase of the cycle when differentiated primary fibers first appear. However, a few hours later, many cells in S phase surround newly formed muscle fibers, suggesting that the latter may be a source of mitogens for undifferentiated myoblasts. Co-culture experiments supported this hypothesis, showing that medium conditioned by fiber-containing explants can stimulate myoblast proliferation. Taken together these data suggested a possible mechanism for the regulation of muscle fiber formation. The model assumes that fibers form in the proximal region of the limb bud, where TGF beta is known to be present, and BrdU labeling experiments did not reveal cells in S phase. It is conceivable that non-dividing embryonic myoblasts (which do not respond to TGF beta) can undergo differentiation, while fetal myoblasts are inhibited by TGF beta. Once formed, primary fibers may stimulate a new wave of proliferation in fetal myoblasts, in order to expand the pool of cells needed to form secondary fibers.(ABSTRACT TRUNCATED AT 250 WORDS)
ChemInform Abstract: Synthesis Conditions and Oxygen Stoichiometry Effects on Li Insertion into the Spinel LiMn2O4. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Confirmation of the severe phenotypic effect of serine at codon 41 of the superoxide dismutase 1 gene (2011)

The more rapid course of ALS with the Gly41Ser SOD1 mutation is confirmed in a distinct ethnic group.
Mechanistic Insights into LDL Nanoparticle-Mediated siRNA Delivery (2011)

Although small interfering RNA (siRNA) can silence the expression of disease-related genes, delivery of these highly charged molecules is challenging. Delivery approaches for siRNAs are actively being pursued, and improved strategies are required for nontoxic and efficient delivery for gene knockdown. Low density lipoprotein (LDL) is a natural and endogenous nanoparticle that has a rich history as a delivery vehicle. Here, we examine purified LDL nanoparticles as carriers for siRNAs. When siRNA was covalently conjugated to cholesterol, over 25 chol-siRNA could be incorporated onto each LDL without changing nanoparticle morphology. The resulting LDL-chol-siRNA nanoparticles were selectively taken up into cells via LDL receptor mediated endocytosis, resulting in enhanced gene silencing compared to free chol-siRNA (38% gene knock down versus 0% knock down at 100 nM). However, silencing efficiency was limited by the receptor-mediated entrapment of the LDL-chol-siRNA nanoparticles in endolysosomes. Photochemical internalization demonstrated that endolysosome disruption strategies significantly enhance LDL-mediated gene silencing (78% at 100 nM).
Effect of Flux On Luminescence of Eu2+ Activated Yellow Oxynitride Phosphor (2013)

Abstract not Available.
Coordination networks incorporating halogen-bond donor sites and azobenzene groups (2016)

A coordination network decorated with halogen-bond donor sites for specific guest binding.
Image-guided Raman spectroscopic recovery of canine cortical bone contrast in situ (2008)

Raman scattering provides valuable biochemical and molecular markers for studying bone tissue composition with use in predicting fracture risk in osteoporosis. Raman tomography can image through a few centimeters of tissue but is limited by low spatial resolution. X-ray computed tomography (CT) imaging can provide high-resolution image-guidance of the Raman spectroscopic characterization, which enhances the quantitative recovery of the Raman signals, and this technique provides additional information to standard imaging methods. This hypothesis was tested in data measured from Teflon tissue phantoms and from a canine limb. Image-guided Raman spectroscopy (IG-RS) of the canine limb using CT images of the tissue to guide the recovery recovered a contrast of 145:1 between the cortical bone and background. Considerably less contrast was found without the CT image to guide recovery. This study presents the first known IG-RS results from tissue and indicates that intrinsically high contrasts (on the order of a hundred fold) are available.
Spatial multiplexing and channel statistics-based RF pre-processing for antenna selection (2005)

For a multiple input multiple output system, antenna selection reduces complexity at the expense of performance. In this paper, we propose two novel RF pre-processing architectures that significantly improve the performance of antenna selection, while marginally increasing the complexity. These architectures introduce an RF pre-processing matrix, M, that multiplies the vector of incoming signals prior to downconversion. The elements of M use only the knowledge of the channel statistics. In the first architecture, M outputs a reduced number of streams - an explicit selection algorithm is therefore not required. In the second architecture, the number of output streams equals the number of input streams, and the reduction of the number of streams is achieved by a selection switch that uses instantaneous channel state information. We show that the optimal pre-processing receiver projects the received signal along the eigenvectors of the correlation matrix. In a correlated channel, both these architectures significantly outperform conventional antenna selection. We also develop a beam-pattern based intuition and compare the performance of our scheme to other RF preprocessing schemes previously proposed in the literature.
Temperature determination of SiC MPS diodes during surge current event with measurement and simulation (2019)

The surge current ruggedness is an important factor for a diode in power electronic applications. The diodes will face very high temperatures during a surge current event. In this work, the temperature was determined during surge current event of SiC MPS diodes under different pulse lengths using measurement and numerical simulation. Even though SiC itself can withstand very high temperatures, the maximum operating temperature of the diode is limited by the anode metallization in TO-247 during the surge current event. The temperature distribution during the surge current event was analysed and explained in detail with help of numerical simulation of the diode model in ANSYS.
Advanced Light Trapping of High-Efficiency Thin Film Silicon Solar Cells (2012)

Kaneka has been proposing and developing the “advanced super-light trapping (ASLT)” structure for thin film silicon solar cells, which incorporates tailored light confinement structures in tandem thin film silicon solar cells to selectively enhance light trapping in top and bottom subcells. In this paper, we present the results of the development of intermediate reflectors with very low refractive index and the design and implementation of nanoimprinted substrates. We demonstrate that significant current gains are possible by reducing the refractive index of the interlayer beyond state-of-the-art values. In addition, we show that the transparent conductive oxide angular scattering properties correlate with the solar cell performance in the infrared part of the spectrum.
Dependence of the saturated light-induced defect density on macroscopic properties of hydrogenated amorphous silicon (1990)

We report a study of the saturated light-induced defect density Ns,sat in 37 hydrogenated (and in part fluorinated) amorphous silicon [a-Si:H(F)] films grown in six different reactors under widely different conditions. Ns,sat was attained by exposing the films to light from a krypton ion laser (λ=647.1 nm). Ns,sat is determined by the constant photocurrent method and lies between 5×1016 and 2×1017 cm−3. Ns,sat drops with decreasing optical gap Eopt and hydrogen content cH, but is not correlated with the initial defect density Ns,ann or with the Urbach tail energy Eu. We discuss our results within the framework of existing models for light-induced defects.