gebhart/patrepeval huggingface dataset:
A study on RAKE reception using multicarrier template waveform for UWB-IR system (2012)

Frequency selective fading that is caused by the multipath becomes a problem in broad band communication like a UWB (Ultra Wideband) system. This paper discusses the RAKE reception technique by using the multicarrier template waveform in the UWB-IR (Impulse Radio) system to compensate the influence of multipath. The template waveform in the UWB receiver is modified to the multicarrier pulse, because the power spectrum density can be controlled to weight for the sub-band pulses. The BER (Bit Error Rate) performance is improved, because more powerful path can be detected in each sub-band pulse of the multicarrier template waveform and the correlation values of the RAKE branches can be combined efficiently.
Functional Analysis of Cardiovascular Renin-Angiotensin System Using a Gain or Loss of Function Approach. (2000)

The study of the effect of autocrine-paracrine vasoactive modulators on cardiovascular biology is very difficult in vivo, because in vivo studies are limited. In particular, characterization of the role of components of the renin-angiotensin system (RAS) in vivo is limited by the difficulty in manipulating individual components of the RAS as well as by methodological limitations in studying the function of a local RAS in the absence of any contribution by the circulatory system. Recent progress in in vivo gene transfer technologies has provided us with the opportunity to study cellular responses to the manipulation of the individual components (i.e., by overexpression or inhibition). Many researchers have recently developed various in vivo gene transfer techniques for cardiovascular applications. Using in vivo gene transfer approaches, the roles of various tissues in the RAS, such as cardiac angiotensin, have been identified. Such an approach may increase our understanding of the biology and pathobiology of the autocrine-paracrine system. This review discusses the potential utility of in vivo gene transfer methods.
Serial Imaging of Luciferase Positive Bone Marrow Stromal Cell Migration to Form Radiation Pulmonary Fibrosis (2012)

Abstract Abstract 4734 Thoracic irradiation of C57BL/6 mice leads to an acute reaction phase in the lungs characterized by increased cytokine production and inflammation days 1–14 post irradiation. This is followed by a latent period where inflammation, histologic appearance and cytokine response returns to control levels. The late reaction phase occurs 100+ days post irradiation and is characterized by organizing alveolitis/fibrosis and involves migration of marrow origin macrophages and proliferating mesenchymal stem cells (fibroblasts), a subpopulation which migrates from marrow to the lungs. To quantitate migration in real time, thoracic irradiated mice were either made chimeric for luciferase positive (luc+) whole marrow or were injected with cells from a positive luc+ bone marrow stromal cell line and serially imaged at day 7, 60 or 120 using an IVIS.. 200 Optical Imaging System. As a control for migration to the lung, another group of mice received 20Gy to the right hind leg and 1.5 ×106 luc+ bone marrow stromal cells i.p. Imaging of chimeric mice revealed luc+ cell lung migration only after day 120. C57BL/6NTac female mice that received 20Gy thoracic irradiation followed by an i.p. injection 1.5 × 106 luc+ positive bone marrow stromal cells revealed no migration of luc+ cells to the lungs at day 7 or day 60. Furthermore there was no migration to 20Gy irradiated leg at any timepoint. In marked contrast, at the time of the late reaction phase, at day 100, fibrosis was revealed as an increase in luc+ cell migration in lungs. The lung fibrosis model in C57BL/6 mice combined with live imaging allows sequential measurement of the effect of agents which may alter migration of bone marrow cells that contribute to radiation pulmonary fibrosis. Disclosures: No relevant conflicts of interest to declare.
AN AUGMENTED WAVELET - NEURO-FUZZYMODULE FOR ENHANCING MEMS BASEDNAVIGATIONSYSTEMS (2007)

Lowcostnavigation systems relying ongyroscopes and accelerometers manufactured usingmicroelectromechanical system(MEMS)technology havebeen recently utilized inlandvehicles. TheseMEMS-based sensors areintegrated withGPS toprovide reliable positioning solutions incaseofGPS outages that commonly occur inurban areas. Themajor inadequacies ofMEMS-based navigation sensors arethehighnoise level andthelarge bias instabilities that arestochastic in nature. Theeffects oftheseinadequacies manifest themselves aslarge position errors during GPSoutages. Thisresearch proposes theutilization ofwavelet denoising toimprove thesignal-to-noise ratio ofeachofthe MEMS-based sensors. Inaddition aneuro-fuzzy module isusedtoprovide areliable prediction ofthevehicle position during GPSoutages. Theresults fromaroadtest experiment showtheeffectiveness oftheproposed wavelet -neuro-fuzzy module.
Arbitrary error detection in a planar lattice of the surface code (2015)

single-qubit error applied to the codeword and show that this error can be revealed uniquely in the syndromes. The -non-trivialgeometric arrangement of the qubits is essential to the surface code algorithm and is therefore extendable throughout the two-dimensional plane, encoding progressively larger logical Hilbert spaces towards a fully scaled fault-tolerant quantum computer. 1 We acknowledge support from IARPA under contract W911NF-10-1-0324
HF-Last Wet Clean in Combination with a Low Temperature GeH<sub>4</sub>-Assisted HCl <i>In Situ</i> Clean Prior to Si<sub>0.8</sub>Ge<sub>0.2</sub>-on-Si Epitaxial Growth (2014)

Epitaxial growth requires a clean starting surface for the growth of a high-quality crystalline layer. For epitaxy on Si, an HF-last wet clean followed by an in-situ high-temperature hydrogen bake is the reference pre-epi clean sequence to obtain an oxygen-free surface [1, 2]. The temperature required to remove all residual oxygen also makes the surface atoms mobile, resulting in reflow. The high temperatures used during the H 2 -bake can also result in intolerable doping profile changes. A lower temperature pre-epi clean sequence is required to avoid this reflow, especially when moving away from Si. In addition the high temperatures needed during a H 2 -bake would result in the relaxation of high mobility channels, e.g. strained Si 1-x Ge x or III-V materials [3]. Several low temperatures pre-epi cleaning solutions have been proposed in the past, e.g. GeH 4 -assisted H 2 -bake [4] or more recently, a GeH 4 -assisted HCl clean [5]. In this study we looked at the interaction between HF-last wet clean and the in-situ GeH 4 -assisted HCl clean prior to Si 0.8 Ge 0.2 -on-Si epitaxy.
Cancer cell-derived transforming growth factor (TGF)-β and myeloid cell-derived interleukin (IL)-1β synergize to promote type 2 inflammation and breast cancer progression (2016)

Abstract Human breast cancer displays type 2 inflammation that promotes cancer progression and can be linked with interleukin (IL)-13 signature. The underlying molecular mechanisms include cancer-derived thymic stromal lymphopoietin (TSLP). Here, we found that IL-13 correlates with high levels of IL-1β in primary breast cancers. IL-1β levels correlate with disease stage indicating association with cancer invasiveness. IL-1β induces TSLP promoter activation, enhanced transcription and TSLP protein production from breast cancer cell lines. Administration of IL-1 receptor (IL-1R) antagonist Anakinra prevents breast cancer progression in a humanized mouse model of breast cancer. Conversely, breast cancer cells induce IL-1β transcription and secretion in dendritic cells (DCs) and monocytes. This is mediated by cancer cell-derived transforming growth factor (TGF)-β. TGF-β activated kinase 1 (TAK1) is involved in caspase-1 activation and subsequent IL-1β production. Administration of TGF-β neutralizing antibody prevents breast cancer progression in vivo and this is associated with a blockade of IL-13 and IL-4 production in the tumor. Thus, TGF-β - IL-1β cross-talk drives type 2 inflammation and contributes to breast cancer progression.
Ofatumumab (Arzerra®): a Next‐Generation Human Therapeutic CD20 Antibody with Potent Complement‐Dependent Cytotoxicity (2014)

This chapter contains sections titled: Introduction and Preliminary Comments Physical and Immunochemical Characteristics of OFA Compared to RTX Functional Characterizations CD20: It Is certainly a Good Target, but How Well Characterized Is It? Key Results of Clinical Trials with OFA Summary and Future Directions Abbreviations Disclosures References
Low-Power, Fast Hybrid Silicon Switches for High-Capacity Optical Networks (2010)

We draw a comparison between the energy utilization of electronic and optical routers. A hybrid silicon switch was demonstrated with low power consumption and fast switching speed. Its potential in high-capacity optical networks is discussed.
Can we break the dependency in distributed detection? (2022)

We consider a distributed detection problem where sensors observe dependent observations. We ask, if we can allow the sensors to locally exchange a few bits with each other, whether we can use these bits to "break" the dependency of the sensor observations, and thus reduce the dependent detection problem to the much better-studied and understood case of conditionally independent observations. To this end, we propose an optimization problem that we prove is equivalent to minimizing the dependency between the sensor observations. This problem is in general NP-hard, however, we show that for at least some cases of Gaussian distributions it can be solved efficiently. For general distributions, we propose to use alternating minimization and derive a constant factor approximation algorithm. Numerical evaluations indicate that our approach can offer significant improvement in detection accuracy over alternative schemes.
ChemInform Abstract: Absolute Configuration of Phorboxazoles A and B from the Marine Sponge Phorbas sp. Part 1. Macrolide and Hemiketal Rings. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Phase-Matched Generation of Coherent Soft X-rays (1998)

Phase-matched harmonic conversion of visible laser light into soft x-rays was demonstrated. The recently developed technique of guided-wave frequency conversion was used to upshift light from 800 nanometers to the range from 17 to 32 nanometers. This process increased the coherent x-ray output by factors of 10(2) to 10(3) compared to the non-phase-matched case. This source uses a small-scale (sub-millijoule) high repetition-rate laser and will enable a wide variety of new experimental investigations in linear and nonlinear x-ray science.
P0554IN VITRO ASSESSMENT OF HA330 CARTRIDGE ADSORPTION CAPACITY REALTED TO VANCOMYCIN (2020)

Abstract Background and Aims The rationale for blood purification as adjunctive therapy during sepsis involved the capacity in removing endogenous and exogenous toxins, but currently no recommendations exists [1]. A critical point may be the potential interaction with antimicrobial therapy, which remains the mainstay of sepsis treatment. HA330 cartridge (Jafron, Zhuhai City, China), widely used in China and actually available in Europe, is used in hemoperfusion for blood purification in septic patients.The aim of this in vitro study was to investigate the adsorptive capacity of HA330 related to vancomycin (VAN). Reference: 1. Rhodes A et al. Crit Care Med 45:486-552. 2017 Method This is an experimental study, simulating an hemoperfusion treatment with HA330. We circulated (250 ml/min) in a closed loop 500 ml of normal saline solution enriched with VAN, stirred and maintained at 37°C. We spiked 100 mg of VAN every 15 minutes to increase the antibiotic load until reaching 1500 mg, the last injection was 500 mg to get a total amount of 2 g. Samples were collected from the inlet line at each VAN adjunct, after system stabilization. Measured VAN concentrations were used to get the adsorption isotherm: for each VAN load, the adsorbed amount of VAN was obtained by multiplying VAN reduction ratio and the quantity of VAN injected. Results Figure 1 shows VAN adsorption isotherm obtained with HA330 cartridge. We observed that, at each injection, after 15 minutes VAN was almost entirely adsorbed by the cartridge, with an average reduction ratio of 0.96. Interestingly, this was confirmed even adding 500 mg at once. Even increasing the VAN load to 500 mg at once, the reduction ratio was maintained. Conclusion In our study, simulating hemoperfusion using HA330, a rapid and clinically relevant removal of VAN has been shown. A significant amount of VAN (2g) was adsorbed without reaching membrane saturation nor reducing its adsorptive capacity. In a clinical setting, we recommend a therapeutic drug monitoring to optimize VAN levels during blood purification with HA330 and a VAN loading dose may be considered. Further in vivo studies are warranted to confirm these findings.
IS-Linked Movement of a Restriction-Modification System (2011)

Potential mobility of restriction-modification systems has been suggested by evolutionary/bioinformatic analysis of prokaryotic genomes. Here we demonstrate in vivo movement of a restriction-modification system within a genome under a laboratory condition. After blocking replication of a temperature-sensitive plasmid carrying a PaeR7I restriction-modification system in Escherichia coli cells, the plasmid was found integrated into the chromosome of the surviving cells. Sequence analysis revealed that, in the majority of products, the restriction-modification system was linked to chromosomal insertion sequences (ISs). Three types of products were: (I) apparent co-integration of the plasmid and the chromosome at a chromosomal IS1 or IS5 copy (24/28 analyzed); (II) de novo insertion of IS1 with the entire plasmid except for a 1-3 bp terminal deletion (2/28); and (III) reciprocal crossing-over between the plasmid and the chromosome involving 1-3 bp of sequence identity (2/28). An R-negative mutation apparently decreased the efficiency of successful integration by two orders of magnitude. Reconstruction experiments demonstrated that the restriction-dependence was mainly due to selection against cells without proper integration: their growth was inhibited by the restriction enzyme action. These results demonstrate collaboration of a mobile element and a restriction-modification system for successful joint migration. This collaboration may have promoted the spread and, therefore, the long-term persistence of these complexes and restriction-modification systems in a wide range of prokaryotes.
Calculation of Magnet Losses in Concentrated-Winding Permanent-Magnet Synchronous Machines Using a Computationally Efficient Finite-Element Method (2013)

The proposed hybrid method combines computationally efficient finite-element analysis (CE-FEA) with a new analytical formulation for eddy-current losses in the permanent magnets (PMs) of sine-wave current-regulated brushless synchronous motors. The CE-FEA only employs a reduced set of magnetostatic solutions yielding substantial reductions in the computational time, as compared with the conventional FEA. The 3-D end effects and the effect of pulsewidth-modulation switching harmonics are incorporated in the analytical calculations. The algorithms are applied to two fractional-slot concentrated-winding interior PM motors with different circumferential and axial PM block segmentation arrangements. The method is validated against 2-D and 3-D time-stepping FEA.
Part II of Field Research: Impact of Centrifuge Torque and Polymer Dose on Odor Production from Anaerobically Digested Biosolids (2005)

Part II of Field Research: Impact of Centrifuge Torque and Polymer Dose on Odor Production from Anaerobically Digested BiosolidsA study was performed to optimize the operation of a high solids centrifuge in terms of dewatering performance as well as the subsequent generation of odors from the biosolids cake. The results are presented in a two paper series, one dealing with the dewatering performance, and the second covering the impact on odors.This is the second paper in the series and will present how centrifuge polymer...Author(s)Matt HigginsKathy HamelYen-Chih ChenSudhir MurthyE.J. BarbenAlex LivadarosMike TravisNicholas MaasSourceProceedings of the Water Environment FederationSubjectSession 18: Odor Issues: Perspectives and ResearchDocument typeConference PaperPublisherWater Environment FederationPrint publication date Jan, 2005ISSN1938-6478SICI1938-6478(20050101)2005:2L.1068;1-DOI10.2175/193864705783967665Volume / Issue2005 / 2Content sourceResiduals and Biosolids ConferenceFirst / last page(s)1068 - 1083Copyright2005Word count157
Abstract 2195: A high-throughput chemical screen identifies synergistic activity between crizotinib and transcriptional CDK inhibitors in ALK-mutated neuroblastoma (2015)

Abstract Activating mutations in the anaplastic lymphoma receptor tyrosine kinase (ALK) represent important therapeutic targets in neuroblastoma (NB). One of the more common mutations, ALKF1174L, is sensitive to the FDA-approved ALK inhibitor, crizotinib, only at high doses and mediates acquired resistance to crizotinib in ALK-rearranged cancers. To identify compounds that would potentiate the effect of crizotinib, we performed a high-throughput compound screen using ALKF1174L-dependent human NB SH-SY5Y cells and compared viability between cells treated with the screen compound alone and in combination with crizotinib. The strongest “hits” among the ∼8,000 compounds screened were inhibitors of cyclin dependent kinases (CDKs). The combination of crizotinib and two candidate pan-selective CDK inhibitors, AT7519 and SNS-032 resulted in synergistic activity with significantly increased apoptosis over that of either single agent alone. This effect was observed in NB cells expressing not only ALKF1174L, but also in those expressing ALKR1275Q, the most common NB-associated ALK mutation. Synergy was also seen with ceritinib (LDK378), a structurally unrelated ALK inhibitor, in combination with both AT7519 and SNS-032. We determined that the synergistic effect was mediated preferentially through the transcriptional, rather than the cell cycle activity of these CDK inhibitors, denoted by absence of cell cycle arrest, stalling of RNA polymerase II at representative gene promoters, and loss of Pol II phosphorylation at the transcription elongation marker serine 2 in treated cells. These findings were comparable with results obtained using agents that were highly selective for CDK9 or CDK7, CDKs with roles in transcription regulation. Finally, in murine xenogaft models of ALK-mutated NB, the combination resulted in inhibition of tumor growth and prolongation of survival compared to single agents alone. Together, these data support further pre-clinical and clinical efforts to explore the therapeutic potential of combining ALK inhibitors with transcriptional CDK inhibitors in ALK-mutated NB. Citation Format: Nathan F. Moore, Edmond Chipumuro, Clark M. Hatheway, Tinghu Zhang, Nathanael S. Gray, Rani E. George. A high-throughput chemical screen identifies synergistic activity between crizotinib and transcriptional CDK inhibitors in ALK-mutated neuroblastoma. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2195. doi:10.1158/1538-7445.AM2015-2195
Homologous NF-YC2 Subunit from Arabidopsis and Tobacco Is Activated by Photooxidative Stress and Induces Flowering (2012)

The transcription factor NF-Y consists of the three subunits A, B and C, which are encoded in Arabidopsis in large gene families. The multiplicity of the genes implies that NF-Y may act in diverse combinations of each subunit for the transcriptional control. We aimed to assign a function in stress response and plant development to NF-YC subunits by analyzing the expression of NF-Y genes and exploitation of nf-y mutants. Among the subunit family, NF-YC2 showed the strongest inducibility towards oxidative stress, e.g. photodynamic, light, oxidative, heat and drought stress. A tobacco NF-YC homologous gene was found to be inducible by photooxidative stress generated by an accumulation of the tetrapyrrole metabolite, coproporphyrin. Despite the stress induction, an Arabidopsis nf-yc2 mutant and NF-YC2 overexpressors did not show phenotypical differences compared to wild-type seedlings in response to photooxidative stress. This can be explained by the compensatory potential of other members of the NF-YC family. However, NF-YC2 overexpression leads to an early flowering phenotype that is correlated with increased FLOWERING LOCUS T-transcript levels. It is proposed that NF-YC2 functions in floral induction and is a candidate gene among the NF-Y family for the transcriptional activation upon oxidative stress.
Human Taste and Umami Receptor Responses to Chemosensorica Generated by Maillard-type N2-Alkyl- and N2-Arylthiomethylation of Guanosine 5′-Monophosphates (2014)

Structural modification of the exocyclic amino function of guanosine 5'-monophosphate (5'-GMP) by Maillard-type reactions with reducing carbohydrates was recently found to increase the umami-enhancing activity of the nucleotide upon S-N(2)-1-carboxyalkylation and S-N(2)-(1-alkylamino)carbonylalkylation, respectively. Since the presence of sulfur atoms in synthetic N(2)-alkylated nucleotides was reported to be beneficial for sensory activity, a versatile Maillard-type modification of 5'-GMP upon reaction with glycine's Strecker aldehyde formaldehyde and organic thiols was performed in the present study. A series of N(2)-(alkylthiomethyl)guanosine and N(2)-(arylthiomethyl)guanosine 5'-monophosphates was generated and the compounds were evaluated to what extent they enhance the umami response to monosodium L-glutamate in vivo by a paired-choice comparison test using trained human volunteers and in vitro by means of cell-based umami taste receptor assay. Associated with a high umami-enhancing activity (β-value 5.1), N(2)-(propylthiomethyl)guanosine 5'-monophosphate could be generated when 5'-GMP reacted with glucose, glycine, and the onion-derived odorant 1-propanethiol, thus opening a valuable avenue to produce high-potency umami-enhancing chemosensorica from food-derived natural products by kitchen-type chemistry.
Antiseizure Activity of Novel γ-Aminobutyric Acid (A) Receptor Subtype-Selective Benzodiazepine Analogues in Mice and Rat Models (2020)

The antiseizure activity of benzodiazepines (BDZs) 1-5 in mice and rats as animal models is described. These BDZs have selective efficacy for α2β3γ2 and α3β3γ2 GABAA-receptors. Significant anticonvulsant activity with little or no motor impairment and therapeutic indexes (TI) of 2.8-44 (mice, ip) were observed for compounds 2-4 in the subcutaneous metrazole seizure (scMET) test. In rats orally (po) the TI was >5 to 105. These compounds represent novel leads in the search for anticonvulsants devoid of sedative, ataxic and amnestic side effects.
<title>Nonlinear fusion of Gabor wavelet filters for locating objects, edges, and clutter</title> (1996)

We note the use of Gabor wavelet filters to locate objects and edges (for detections of regions of interest in scenes), to locate clutter regions (to reduce false alarms) and to produce distortion invariant features (for object classification). We describe new ways to select Gabor filter parameters, new nonlinear ways to combine Gabor function outputs for improved performance and to reduce the number of filters necessary.