gebhart/patrepeval huggingface dataset:
A New Small-Sized Non-Dispersive Infrared (NDIR) Sensor and its Drive/Readout Circuits (2016)

A new miniaturized, non-dispersive, infrared (NDIR) sensor for CO2 intended to be installed in mobile phones and its drive/readout circuits are presented in this study. A typical NDIR sensor consists of three main components; an infrared (IR) light-emitter (light source), a gas chamber, a photo detector (PD) light receiver) and the associated drive/readout circuits. The geometry of the gas chamber is optimized to minimize the total module size to approximately 10 mm × 5 mm × 5 mm, which is much smaller than commercially-available gas sensors. Driver and readout circuits are successfully designed and taped out. The driver circuit intends to generate pulse width modulation (PWM) signal to control proper dimming of LED. The readout circuit, which acquires small signal from photo detector then converts to digital values, includes amplifier, low pass filter and analog-to-digital converter (ADC). The proposed circuit is fabricated by the TSMC 0.35-μm CMOS process, where the area is 4.527 mm2 while power consumption is 60.16 mW for the whole chip. The resolution is less than 12 ppm along with time constant is 0.1 sec.
Drug Delivery Approaches for the Treatment of Cervical Cancer (2016)

Cervical cancer is a highly prevalent cancer that affects women around the world. With the availability of new technologies, researchers have increased their efforts to develop new drug delivery systems in cervical cancer chemotherapy. In this review, we summarized some of the recent research in systematic and localized drug delivery systems and compared the advantages and disadvantages of these methods.
Kinetic analysis of demethylation of 13C-aminopyrine in healthy dogs (2004)

PCD appears to be the preferable variable for evaluation of hepatic demethylating capacity. Intravenous administration of 13C-aminopyrine leads to a consistent increase in PCD. Mean PCD peaked 45 minutes after administration, suggesting that blood sample collection 45 minutes after 13C-aminopyrine administration may be appropriate for use in estimating hepatic demethylating capacity.
Efficacy of genogroup 1 based porcine epidemic diarrhea live vaccine against genogroup 2 field strain in Japan (2018)

The conventional PED live vaccine induced the lactogenic immunity to vaccinated sows and showed partial protection against the genogroup 2 virus both under the experimental and field conditions.
Reducing the Margins of Error During Breast-Conserving Surgery (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Relationship between Macroscopic Strain and Lattice Strain of Titanium (2003)

The purpose of this study is to investigate the relationship between macroscopic strain and lattice strain of titanium. A measuring method of the lattice strain of crystal under loading was developed by using diffracted X-rays which penetrate through the specimen. A small equipment of tensile loading while irradiated with X-ray was made. In this experiment, specimens of 50mm length and 5mm width were made from pure titanium (α-Ti) of 0.1mm thickness and titanium alloy (β-Ti) of 0.13mm thickness. Strains of (100), (101), (102), (110), (112), (200), (203), (211) lattice planes of α-Ti and (110), (211), (220), (321) lattice planes of β-Ti were measured by this method. Macroscopic strain was measured by the strain gauge on the specimen surface. As a result, those lattice strains of every specimens showed values approximately from 70% to 100% of macroscopic strains.
Perfusion dyssynchrony analysis (2015)

These findings suggest that perfusion dyssynchrony analysis is a robust novel approach to the analysis of first-pass perfusion and has the potential to add complementary information to aid assessment of CAD.
Celebrating three decades of excellence in pharmacy management: The John W. Webb Lecture award (2014)

Sweeping and profound changes in any profession do not come easily; they require thoughtful, focused, and persistent leadership. Over many years, key leaders and managers in the profession of pharmacy have set bold and exciting directions that have enabled health systems to better serve the needs of specific patients while improving overall quality and safety across systems and populations. In this respect, review and analysis of the many aspects of a remarkable evolution of health-system pharmacy, as well as key contributions of individual leaders, become instructive as we prepare ourselves for the many changes and uncertainties that lie ahead for our profession and health care in general. Through this article, we will describe a program that has for nearly 30 years identified, acknowledged, and celebrated the accomplishments of distinguished leaders and managers and identify and explore their collective wisdom and contributions. Most pharmacy leaders are recognized for their willingness to place service to others, particularly patients, at the center of all that they do. These leaders are known for their personal integrity, strategic thinking, system approaches, and thoughtful mentoring. Such is the basis for recognition in our profession through the John W. Webb Lecture Award program. The Webb Lecture, established in 1985 as the John W. Webb Visiting Professorship in Hospital Pharmacy by Northeastern University College of Pharmacy, recognizes annually one health-system pharmacy practitioner or educator who has distinguished herself or himself through extraordinary dedication to fostering excellence in pharmacy management. The award honors John W. Webb, director of pharmacy at Massachusetts General Hospital from 1959 to 1983 and director of the graduate program in hospital pharmacy at Northeastern University from 1964 to 1983. Mr. Webb had a distinguished career in hospital pharmacy management and was an exemplary leader and innovator who always placed patients first, and he expected the same of his colleagues. In 2006, a memorandum of understanding between ASHP and Northeastern University transferred responsibility for the award to ASHP. The ASHP Section of Pharmacy Practice Managers began administering the annual selection process in 2007. Most Webb Lectures have been published in the American Journal of Health-System Pharmacy ( Appendix A). The complete list of past Webb Lecture Award recipients is presented in Appendix B.
Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells (2011)

Fine tuning of the protein folding environment in subcellular organelles, such as mitochondria, is important for adaptive homeostasis and may participate in human diseases, but the regulators of this process are still largely elusive. Here, we have shown that selective targeting of heat shock protein-90 (Hsp90) chaperones in mitochondria of human tumor cells triggered compensatory autophagy and an organelle unfolded protein response (UPR) centered on upregulation of CCAAT enhancer binding protein (C/EBP) transcription factors. In turn, this transcriptional UPR repressed NF-κB-dependent gene expression, enhanced tumor cell apoptosis initiated by death receptor ligation, and inhibited intracranial glioblastoma growth in mice without detectable toxicity. These data reveal what we believe to be a novel role of Hsp90 chaperones in the regulation of the protein-folding environment in mitochondria of tumor cells. Disabling this general adaptive pathway could potentially be used in treatment of genetically heterogeneous human tumors.
A deep trench capacitor based 2:1 and 3:2 reconfigurable on-chip switched capacitor DC-DC converter in 32 nm SOI CMOS (2014)

On-chip switched capacitor (SC) converters for multicore microprocessor power delivery have the potential to reduce the overall energy consumption of future multicore microprocessor systems by independently regulating the voltage supply of each core. This paper describes an on-chip SC converter that can be reconfigured between a 2:1 and a 3:2 voltage conversion ratio to support a wide output voltage range from a single input supply. Regarding SC converter analysis and modeling, this paper extends an existing state space model framework to include the flying capacitors' parasitic bottom plate capacitors, which for on-chip SC converters significantly influence both the capacitor currents and the converter efficiency. A reconfigurable SC converter that supports an output voltage range of 700mV to 1150mV from a 1.8V input supply is implemented in a 32nm SOI CMOS technology that features the high-density deep trench capacitor. The converter achieves a maximum efficiency of 85.2% at 2.1W/mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> power density in the 2:1 configuration and a maximum efficiency of 84.1% at 3.2W/mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> in the 3:2 configuration.
Interactions between Redox Complexes and Semiconductor Quantum Dots Coupled via a Peptide Bridge (2008)

Colloidal quantum dots (QDs) have a large fraction of their atoms arrayed on their surfaces and are capped with bifunctional ligands, which make their photoluminescence highly sensitive to potential charge transfer to or from the surrounding environment. In this report, we used peptides as bridges between CdSe-ZnS QDs and metal complexes to promote charge transfer between the metal complexes and QDs. We found that quenching of the QD emission is highly dependent on the relative position of the oxidation levels of QDs and metal complex used; it also traces the number of metal complexes brought in close proximity of the nanocrystal surface. In addition, partial bleaching of the absorption was measured for the QD-metal complex assemblies. These proximity driven interactions were further used to construct sensing assemblies to detect proteolytic enzyme activity.
Abstract 190: Repeated Doses of Dodecafluoropentane Emulsion Provide Neuroprotection Up to 24 Hours Following Cerebral Artery Occlusion in Rabbits (2013)

Introduction: Neuroprotective strategies in ischemic stroke include oxygen delivery to sustain penumbra and prevent hypoxic cell death. Hyperbaric oxygen, blood substitutes, and liquid fluorocarbon-based oxygen carriers have often failed in treatment of stroke and other ischemic disorders. Dodecafluoropentane emulsion (DDFPe, boiling point 29°C) shifts to quasi-gas phase at body temperature, which allows absorption and transportation of very high levels of oxygen. Exceptionally small particle size, 250-300 nm, may allow oxygen delivery even through occluded vessels, by diffusion into hypoxic tissue unreachable by whole blood. In a preliminary stroke study in rabbits, DDFPe reduced infarct volumes in all experimental groups by 80% or more. Hypothesis: Repeated doses of DDFPe can reduce infarct volume for up to 24 hours after permanent cerebral artery occlusion in rabbits. Methods: New Zealand White rabbits (N=55) received cerebral angiography from a femoral artery approach. Embolic microspheres (diameter=700-900 μm) were injected into the internal carotid artery, permanently occluding the middle cerebral and/or anterior cerebral arteries. Rabbits were randomly assigned to treatment groups and sacrifice times as in Table 1. In all treated groups, intravenous DDFPe dosing with a 2% w/v emulsion began at 1 hour post-embolization and was repeated every 90 minutes until sacrifice at either 7 or 24 hours post-embolization. Following sacrifice, infarcts were measured as a percent of brain volume using vital stains on brain sections. Results: Percent infarct volume means significantly decreased for all DDFPe treated groups compared with controls (Table 1). Conclusion: Intravenous DDFPe begun 1 hour after stroke onset protects the brain from ischemic injury in the rabbit model of permanent embolic stroke. Decreased infarct volumes represent salvaged brain tissue. This effect can be observed for 24 hours with repeated doses.
A Cas9-fusion proximity-based approach generates an Irak1-Mecp2 tandem duplication mouse model for the study of MeCP2 duplication syndrome (2023)

Abstract MECP2 duplication syndrome (MDS) is a neurodevelopmental disorder caused by tandem duplication of the MECP2 locus and its surrounding genes, including IRAK1 . Current MDS mouse models involve transgenic expression of MECP2 only, limiting their applicability to the study of the disease. Herein, we show that an efficient and precise CRISPR/Cas9 fusion proximity-based approach can be utilized to generate an Irak1-Mecp2 tandem duplication mouse model. The Mecp2 Dup model displays a neurological phenotype in keeping with MDS and demonstrates an abnormal immune response to infection not previously observed in other mouse models, possibly stemming from concurrent Irak1 overexpression. The Mecp2 Dup mouse line thus provides an innovative tool to investigate disease mechanisms and potential therapeutic development.
Analysing the interaction between braking control and speed estimation: The case of two-wheeled vehicles (2008)

The availability of actuators capable of a very fine-grained modulation of both traction and braking torques makes the design of slip-based braking control strategies for two-wheeled vehicles a real possibility. As the wheel slip cannot be directly measured, one has to use some estimate of the vehicle speed. The most commonly used speed estimate for two-wheeled vehicles is the fastest wheel speed. This paper investigates the interaction between control and estimation in braking control design for two-wheeled vehicles. Specifically, it is shown that a slip controller can be designed which guarantees global asymptotic stability under perfect knowledge of the vehicle speed. Conversely, when such a controller is fed by the fastest wheel speed stability is lost.
3.7 m&#x03A9;-cm<sup>2</sup>, 1500 V 4H-SiC DMOSFETs for advanced high power, high frequency applications (2011)

We present our most recent developments in 4H-SiC DMOSFETs. A 4H-SiC DMOSFET with an active area of 0.1 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> showed a specific on-resistance of 3.7 mΩ-cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> with a gate bias of 20 V, and an avalanche voltage of 1500 V with gate shorted to source at 25°C. A threshold voltage of 3.5 V was extracted from the DMOSFET, and a subthreshold swing of 200 mV/dec was measured. The device was successfully scaled to an active area of 0.5 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , and the resulting device showed a drain current of 377 A at a forward voltage drop of 3.8 V at 25°C.
Poly(aryl ether phenylquinoxalines) via anionic ring opening polymerization of macrocycles (1997)

Abstract A cyclic poly(aryl ether phenylquinoxaline) was prepared via the self‐polymerization of 1 in an N‐methyl‐2‐pyrrolidone (NMP) solution containing base using a pseudo‐high dilution polymerization condition. The macrocycle formation of 1 was carried out in the presence of potassium carbonate in a NMP/toluene solvent mixture at a solids content of 1%. The water generated by phenoxide formation was removed as an azeotrope with toluene 170 °C. A concentrated solution of the macrocycle was added to the reaction mixture over an 8 hour period. The reaction was allowed to proceed for an additional 24h to ensure quantitative reaction. A number of characterization techniques were used to study the cyclization of 1 including GPC, HPLC, H NMR and matrix‐assisted laser desorption ionization (MALDI) mass spectroscopy. The MALDI‐TOF mass spectrum of the cyclization of 1 clearly showed that a mixture of macrocycles is obtained, with the expected distribution of molecular weights. Facile ring opening polymerization of the cyclic poly(aryl ether phenylquinoxaline) oligomers was accomplished with a nucleophilic initiator. High polymer was obtained for each polymerization temperature (η = 0.4–0.5 dl/g in NMP), however, prolonged reaction time resulted in significant gel formation. The Tg's were high and commensurate with the high molecular weight linear analog (250 °C).
Comparison of delayed administration of competitive and uncompetitive antagonists in preventing NMDA receptor‐mediated neuronal death (1990)

Activation of N-methyl-D-aspartate (NMDA) receptors is thought to mediate toxic damage to central neurons due to hypoxia-ischemia, hypoglycemia, and trauma. We studied identified rat retinal ganglion cell neurons in vitro, a useful system for the study of excitotoxicity, and compared the protective effects of delayed administration of a competitive antagonist, 2-amino-5-phosphonovalerate (APV), and of an uncompetitive antagonist, MK-801, after glutamate-induced injury. We used maximally protective doses of the 2 antagonists. Under these conditions, both antagonists were able to prevent neuronal cell death if they were present within minutes of exposure to an endogenous glutamate-related toxin. In contrast, MK-801, but not APV, protected significantly against NMDA-mediated neurotoxicity when administered 1 to 4 hours after the initial insult. Thus, at least under certain conditions, an uncompetitive NMDA antagonist may offer a distinct advantage over a competitive antagonist when given several hours after a neurologic injury.
Green Chemistry for Tropical Diseases (2012)

This chapter contains sections titled: Introduction Interventions in Drug Dosing Active Pharmaceutical Ingredient Cost Reduction with Green Chemistry Conclusions References
Effect of fluoxetine on disease progression in a mouse model of ALS (2014)

Selective serotonin reuptake inhibitors (SSRIs) and other antidepressants are often prescribed to amyotrophic lateral sclerosis (ALS) patients; however, the impact of these prescriptions on ALS disease progression has not been systematically tested. To determine whether SSRIs impact disease progression, fluoxetine (Prozac, 5 or 10 mg/kg) was administered to mutant superoxide dismutase 1 (SOD1) mice during one of three age ranges: neonatal [postnatal day (P)5-11], adult presymptomatic (P30 to end stage), and adult symptomatic (P70 to end stage). Long-term adult fluoxetine treatment (started at either P30 or P70 and continuing until end stage) had no significant effect on disease progression. In contrast, neonatal fluoxetine treatment (P5-11) had two effects. First, all animals (mutant SOD1(G93A) and control: nontransgenic and SOD1(WT)) receiving the highest dose (10 mg/kg) had a sustained decrease in weight from P30 onward. Second, the high-dose SOD1(G93A) mice reached end stage ∼8 days (∼6% decrease in life span) sooner than vehicle and low-dose animals because of an increased rate of motor impairment. Fluoxetine increases synaptic serotonin (5-HT) levels, which is known to increase spinal motoneuron excitability. We confirmed that 5-HT increases spinal motoneuron excitability during this neonatal time period and therefore hypothesized that antagonizing 5-HT receptors during the same time period would improve disease outcome. However, cyproheptadine (1 or 5 mg/kg), a 5-HT receptor antagonist, had no effect on disease progression. These results show that a brief period of antidepressant treatment during a critical time window (the transition from neonatal to juvenile states) can be detrimental in ALS mouse models.
Carbon tetrachloride doped AlxGa1−xAs grown by metalorganic chemical vapor deposition (1990)

A dilute mixture of CCl4 in H2 has recently been shown to be a suitable carbon doping source for obtaining p-type GaAs grown by metalorganic chemical vapor deposition (MOCVD) with carbon acceptor concentrations in excess of 1×1019 cm−3. To understand the effect of growth parameters on carbon incorporation in CCl4-doped AlxGa1−xAs, carbon acceptor concentration was studied as a function of Al composition, growth temperature, growth rate, and CCl4 flow rate using electrochemical capacitance-voltage profiling. The carbon incorporation as a function of Al composition, growth temperature, and CCl4 flow rate was also measured by secondary-ion mass spectroscopy. All layers were grown by low-pressure MOCVD using TMGa and TMAl as column III precursors, and 100% AsH3 as the column V source. Increased Al composition reduced the dependence of carbon concentration on the growth temperature. Reduced growth rate, which resulted in substantially decreased carbon acceptor concentrations in GaAs, had an insignificant effect on the carrier concentration of Al0.4Ga0.6As. A linear relationship between hole concentration and CCl4 flow rate in AlxGa1−xAs for 0.0≤x≤0.8 was observed. These results are interpreted to indicate that adsorption and desorption of CCly (y≤3) on the AlxGa1−xAs surface during crystal growth plays an important role in the carbon incorporation mechanism.
Integration of Distinct ShcA Signaling Complexes Promotes Breast Tumor Growth and Tyrosine Kinase Inhibitor Resistance (2018)

The commonality between most phospho-tyrosine signaling networks is their shared use of adaptor proteins to transduce mitogenic signals. ShcA (<i>SHC1</i>) is one such adaptor protein that employs two phospho-tyrosine binding domains (PTB and SH2) and key phospho-tyrosine residues to promote mammary tumorigenesis. Receptor tyrosine kinases (RTK), such as ErbB2, bind the ShcA PTB domain to promote breast tumorigenesis by engaging Grb2 downstream of the ShcA tyrosine phosphorylation sites to activate AKT/mTOR signaling. However, breast tumors also rely on the ShcA PTB domain to bind numerous negative regulators that limit activation of secondary mitogenic signaling networks. This study examines the role of PTB-independent ShcA pools in controlling breast tumor growth and resistance to tyrosine kinase inhibitors. We demonstrate that PTB-independent ShcA complexes predominately rely on the ShcA SH2 domain to activate multiple Src family kinases (SFK), including Src and Fyn, in ErbB2-positive breast cancers. Using genetic and pharmacologic approaches, we show that PTB-independent ShcA complexes augment mammary tumorigenesis by increasing the activity of the Src and Fyn tyrosine kinases in an SH2-dependent manner. This bifurcation of signaling complexes from distinct ShcA pools transduces non-redundant signals that integrate the AKT/mTOR and SFK pathways to cooperatively increase breast tumor growth and resistance to tyrosine kinase inhibitors, including lapatinib and PP2. This study mechanistically dissects how the interplay between diverse intracellular ShcA complexes impacts the tyrosine kinome to affect breast tumorigenesis.<b>Implications:</b> The ShcA adaptor, within distinct signaling complexes, impacts tyrosine kinase signaling, breast tumor growth, and resistance to tyrosine kinase inhibitors. <i>Mol Cancer Res; 16(5); 894-908. ©2018 AACR</i>.