gebhart/patrepeval huggingface dataset:
The impact of PICALM genetic variations on reserve capacity of posterior cingulate in AD continuum (2016)

Phosphatidylinositolbinding clathrin assembly protein (PICALM) gene is one novel genetic player associated with late-onset Alzheimer's disease (LOAD), based on recent genome wide association studies (GWAS). However, how it affects AD occurrence is still unknown. Brain reserve hypothesis highlights the tolerant capacities of brain as a passive means to fight against neurodegenerations. Here, we took the baseline volume and/or thickness of LOAD-associated brain regions as proxies of brain reserve capacities and investigated whether PICALM genetic variations can influence the baseline reserve capacities and the longitudinal atrophy rate of these specific regions using data from Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset. In mixed population, we found that brain region significantly affected by PICALM genetic variations was majorly restricted to posterior cingulate. In sub-population analysis, we found that one PICALM variation (C allele of rs642949) was associated with larger baseline thickness of posterior cingulate in health. We found seven variations in health and two variations (rs543293 and rs592297) in individuals with mild cognitive impairment were associated with slower atrophy rate of posterior cingulate. Our study provided preliminary evidences supporting that PICALM variations render protections by facilitating reserve capacities of posterior cingulate in non-demented elderly.
Multi-slot Transmission with Effective Frequency Hopping and DMRS Bundling for 5G NR Coverage Enhancement (2022)

The paper proposes an effective method of data transmission over New Radio (NR) Uplink (UL) channel to improve coverage of 5G wireless communication systems. This method is based on the dedicated time-frequency allocation pattern that makes it possible to combine inter-slot frequency hopping (FH) and demodulation reference signals (DMRS) bundling for joint channel estimation in a newly developed method of multi-slot data transmission over UL channel of 5G NR networks. The proposed approach demonstrates the improvement of coverage by utilizing the benefit of both mentioned coverage enhancement techniques and, therefore, may be recommended for application in future 5G communication networks. The performance improvement, when using the proposed algorithm, was tested using the link level simulator of the communication system based on the 3rd Generation Partnership Project (3GPP) standard for 5G NR mobile networks.
Supplementary Figure Legends 1-13 from p53 Regulates the Ras Circuit to Inhibit the Expression of a Cancer-Related Gene Signature by Various Molecular Pathways (2023)

Supplementary Figure Legends 1-13 from p53 Regulates the Ras Circuit to Inhibit the Expression of a Cancer-Related Gene Signature by Various Molecular Pathways
How Crouch Gait Can Dynamically Induce Stiff-Knee Gait (2010)

Children with cerebral palsy frequently experience foot dragging and tripping during walking due to a lack of adequate knee flexion in swing (stiff-knee gait). Stiff-knee gait is often accompanied by an overly flexed knee during stance (crouch gait). Studies on stiff-knee gait have mostly focused on excessive knee muscle activity during (pre)swing, but the passive dynamics of the limbs may also have an important effect. To examine the effects of a crouched posture on swing knee flexion, we developed a forward-dynamic model of human walking with a passive swing knee, capable of stable cyclic walking for a range of stance knee crouch angles. As crouch angle during stance was increased, the knee naturally flexed much less during swing, resulting in a 'stiff-knee' gait pattern and reduced foot clearance. Reduced swing knee flexion was primarily due to altered gravitational moments around the joints during initial swing. We also considered the effects of increased push-off strength and swing hip flexion torque, which both increased swing knee flexion, but the effect of crouch angle was dominant. These findings demonstrate that decreased knee flexion during swing can occur purely as the dynamical result of crouch, rather than from altered muscle function or pathoneurological control alone.
Local Birefringence in Unidirectionally Spun Fibers (2006)

The application of a spinning step in the drawing process is known to improve optical-fiber polarization mode dispersion. For a more comprehensive understanding of the mechanism through which spinning modifies fiber performances, in this paper, the authors investigate the effect of unidirectional spinning on local fiber birefringence in terms of the effectiveness of spin-function transfer and reduction of the local intrinsic birefringence under different drawing conditions. The actual frozen-in spin is experimentally recovered by means of a cut-back procedure. Different from the case of a periodic spinning, a unidirectional spinning correctly reproduces the nominally imparted spin rate in agreement with theoretical modelizations of the transfer effectiveness of the spinning process. A theoretical explanation for the experimental evidence, recently proved by tomographic stress measurements, of spinning affecting fiber linear intrinsic birefringence is provided. In particular, the interaction of drawing parameters and spinning process in defining stress development into fibers is considered. To validate the proposed model, further tomographic reconstructions of stress profiles in fiber spun at different rates and drawing speed were carried out. Besides, corresponding stress-induced birefringence values were estimated and compared with those recovered by the cut-back technique. Variations of spun fiber beatlength values with respect to the unspun case, as obtained from both measurement techniques, are in good agreement, providing a further reliable confirmation that an improvement of the beatlength may proceed as a consequence of the applied spin
CDM Based Reference Signal Structure Using Oversampling for OFDM Downlink (2011)

This paper proposes code division multiplexing (CDM) based reference signal (RS) multiplexing using oversampling for orthogonal frequency division multiplexing (OFDM) in the downlink. In the proposed RS multiplexing scheme, multiple transmission-stream-specific RSs are multiplexed using orthogonal CDM into the same original resource elements (REs) through oversampling of the fast Fourier transform (FFT) (or inverse fast Fourier transform (IFFT)). Hence, the required REs for the increased number of transmission streams, which correspond to the number of transmission antennas, can be reduced compared to that for the conventional RS multiplexing scheme that uses a combination of frequency division multiplexing (FDM) and time division multiplexing (TDM). Computer simulation results show that when the RSs for the third and fourth streams are multiplexed into the same REs as those for first and second streams using orthogonal CDM, the same block error rate performance is achieved as that for the RS multiplexing based on the Release 8 Long-Term Evolution (LTE) radio interface for 4-antenna space-frequency block code (SFBC) plus frequency switched transmit diversity (FSTD).
Laser Spectral Linewidth Suppression Scheme for Coherent Detection (2013)

We have demonstrated an effective spectral linewidth suppression of commercial TLS using long cavity, narrow bandwidth SBS filter and multi frequency-selection mechanism. Measured linewidth suppression from ~3MHz to less than 20kHz is successfully achieved with a significant SMSR improvement of ~20dB over 30nm range in C-band.
Cytochalasin D induces edema formation and lowering of interstitial fluid pressure in rat dermis (2001)

The increased capillary fluid filtration required to create a rapid edema formation in acute inflammation can be generated by lowering the interstitial fluid pressure (P(IF)). The lowering of P(IF) appears to involve dynamic beta(1)-integrin-mediated interactions between dermal cells and extracellular matrix fibers. The present study specifically investigates the role of the cell cytoskeleton, i.e., the contractile apparatus of cells, in controlling P(IF) in rat skin as the integrins are linked to both the cytoskeleton and the extracellular matrix. P(IF) was measured using a micropuncture technique in the dorsal skin of the hind paw at a depth of 0.2--0.5 mm and following the induction of circulatory arrest with the intravenous injection of KCl in pentobarbital anesthesia. This procedure prevented the transcapillary flux of fluid and protein leading to edema formation in acute inflammation, which in turn can increase the P(IF) and therefore potentially mask a decrease of P(IF). Control P(IF) (n = 42) averaged -0.8 +/- 0.5 (means +/- SD) mmHg. In the first group of experiments, subdermal injection of 2 microl cytochalasin D, a microfilament-disrupting drug, lowered P(IF) to an average of -2.8 +/- 0.7 mmHg within 40 min postinjection (P < 0.05 compared with control). Subdermal injection of vehicle (10% DMSO in PBS or PBS alone) did not change the P(IF) (P > 0.05). Lowering of the P(IF) was not observed after the injection of colchicine or nocodazole, which specifically disrupts microtubuli in cultured cells. In the second group of experiments, 2 microl of cytochalasin D injected subdermally into rats with intact circulation increased the total tissue water (TTW) and albumin extravasation rate (E(ALB)) by 0.7 +/- 0.2 and 0.4 +/- 0.3 ml/g dry wt, respectively (P < 0.05 compared with vehicle). Nocodazole and colchicine did not significantly alter the TTW or E(ALB) compared with the vehicle (P > 0.05). Taken together, these findings strongly suggest that the connective tissue cells can participate in control of P(IF) via the actin filament system. In addition, the observation that subdermal injection of cytochalasin D lowered P(IF) indicates that a dynamic assembly and disassembly of actin filaments also occurs in the cells of dermal tissues in vivo.
Improving FoRe: A New Inlet Design for Filtering Samples through Individual Microarray Spots (2017)

In this publication we present an improvement to our previously introduced vertical flow microarray, the FoRe array, which capitalizes on the fusion of immunofiltration and densely packed micron test sites. Filtering samples through individual microarray spots allows us to rapidly analyze dilute samples with high-throughput and high signal-to-noise. Unlike other flowthrough microarrays, in the FoRe design samples are injected into micron channels and sequentially exposed to different targets. This arrangement makes it possible to increase the sensitivity of the microarray by simply increasing the sample volume or to rapidly reconcentrate samples after preprocessing steps dilute the analyte. Here we present a new inlet system which allows us to increase the analyzed sample volume without compromising the micron spot size and dense layout. We combined this with a model assay to demonstrate that the device is sensitive to the amount of antigen, and as a result, sample volume directly correlates to sensitivity. We introduced a simple technique for analysis of blood, which previously clogged the nanometer-sized pores, requiring only microliter volumes expected from an infant heel prick. A drop of blood is mixed with buffer to separate the plasma before reconcentrating the sample on the microarray spot. We demonstrated the success of this procedure by spiking TNF-α into blood and achieved a limit of detection of 18 pM. Compared to traditional protein microarrays, the FoRe array is still inexpensive, customizable, and simple to use, and thanks to these improvements has a broad range of applications from small animal studies to environmental monitoring.
An infrared study of isotopic exchange during methanation over supported rhodium catalysts: an inverse spillover effect (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn infrared study of isotopic exchange during methanation over supported rhodium catalysts: an inverse spillover effectM. A. Henderson and S. D. WorleyCite this: J. Phys. Chem. 1985, 89, 3, 392–394Publication Date (Print):January 1, 1985Publication History Published online1 May 2002Published inissue 1 January 1985https://pubs.acs.org/doi/10.1021/j100249a002https://doi.org/10.1021/j100249a002research-articleACS PublicationsRequest reuse permissionsArticle Views156Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
On lowest density MDS codes (1999)

Let F/sub q/ denote the finite field GF(q) and let h be a positive integer. MDS (maximum distance separable) codes over the symbol alphabet F/sub q//sup b/ are considered that are linear over F/sub q/ and have sparse ("low-density") parity-check and generator matrices over F/sub q/ that are systematic over F/sub q//sup b/. Lower bounds are presented on the number of nonzero elements in any systematic parity-check or generator matrix of an F/sub q/-linear MDS code over F/sub q//sup b/, along with upper bounds on the length of any MDS code that attains those lower bounds. A construction is presented that achieves those bounds for certain redundancy values. The building block of the construction is a set of sparse nonsingular matrices over F/sub q/ whose pairwise differences are also nonsingular. Bounds and constructions are presented also for the case where the systematic condition on the parity-check and generator matrices is relaxed to be over F/sub q/, rather than over F/sub q//sup b/.
REVIEWS (1977)

REVIEWS Get access The Godly Man in Stuart England: Anglicans, Puritans, and the Two Tables, 1620–1670. By J. SEARS MCGEE . Pp. xviii+299. (Yale Historical Publications Miscellany, 110. ) New Haven and London: Yale University Press, 1976. £11.55. MICHAEL WATTS MICHAEL WATTS Search for other works by this author on: Oxford Academic Google Scholar The Journal of Theological Studies, Volume XXVIII, Issue 2, October 1977, Pages 583–584, https://doi.org/10.1093/jts/XXVIII.2.583 Published: 01 October 1977
Electrical Characteristics of Thin Cerium Oxide Film on Silicon Substrate by Reactive DC Sputtering (2001)

Electrical properties of films prepared by reactive dc sputtering on Si(100) substrate with and without the incorporation of a thin barrier layer were investigated. X-ray diffraction spectra revealed that without the thin barrier layer, single-crystal is formed on Si(100) substrate. At an equivalent oxide thickness of 2.8 nm, films exhibit a leakage current which is four orders of magnitude lower than that of the conventional film at an applied bias of 2 V. Only negligible stress-induced leakage current is observed after high field stressing. The incorporation of the thin silicon nitride buffer layer, however, degraded the crystalline structure of accompanied by deteriorated electrical properties such as leakage current and fixed charges. film without the barrier layer is thus attractive as the high dielectric constant gate insulator for future ultralarge scale integration devices. © 2001 The Electrochemical Society. All rights reserved.
ChemInform Abstract: Laser Flash Photolysis Studies of Novel Xanthene Dye Derivatives (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ERRATUM: Inhibitory and Inductive Effects of Rifampin on the Pharmacokinetics of Bosentan in Healthy Subjects (2007)

Clin Pharmacol Ther advance online publication, January 24, 2007; doi:10.1038/sj.clpt.6100075 In this article, published online on January 24, 2007, the sequence of the authors was incorrect; the correct sequence is shown above.
Biosynthesis of malonomicin. Part 1. 13C nuclear magnetic resonance spectrum and feeding experiments with 13C-labelled precursors (1979)

The 13C·n.m.r. spectrum of malonomicin (1) has been completely assigned. The biosynthesis of malonomicin was studied in Streptomyces rimosus by feeding experiments with 13C-labelled precursors. Evidence is presented that malonomicin is derived from 2, 3-diaminopropanoic acid, one molecule of acetate, a C4-dicarboxylic acid (presumably succinic acid), CO2, and serine.
Human vascular tissues produce thromboxane as well as prostacyclin (1983)

Four different types of human blood vessels were examined for spontaneous and arachidonate-stimulated release of prostacyclin (PGI2) and thromboxane A2 (TXA2). Spontaneous PGI2 release was umbilical veins greater than umbilical arteries greater than saphenous veins greater than internal mammary arteries. With stimulation, PGI2 release by all four different vessels increased significantly (P less than 0.001) and was similar. Spontaneous release of TXA2 was also identified from all vessels examined and was similar. With stimulation, TXA2 release from all vessels increased significantly (P less than 0.001). Internal mammary artery released more TXA2 than other vessels on stimulation. The identity of TXA2 was confirmed by similar displacement of TXB2 antibody by TXB2 standards and by multiple dilutions of supernates. Treatment of vessels with aspirin inhibited PGI2 as well as TXA2 release, whereas treatment with OKY 1581 (TXA2 synthetase inhibitor) inhibited TXA2 release only. Two-dimensional thin-layer chromatography showed [14C]arachidonate conversion to PGI2 and TXA2 similar to that measured by radioimmunoassay. These data suggest that TXA2 is synthesized by human vessels. In older vessels when PGI2 generation is decreased, TXA2 production may by of pathophysiological significance.
Improving service rate granularity by dual-rate session grouping in cell-based schedulers (2002)

In this paper we propose a scheme referred to as dual-rate session grouping to improve the service rate granularity for cell-based schedulers. In this scheme a session is split into two subsessions to provide the average service rate that a user requires. By applying dual-rate session grouping, the utilization of bandwidth and fairness among users can be improved, while the complexity of the scheduling algorithm remains the same as the conventional scheme. The overall computational complexity of the dual-rate session grouping does not increase with the rate granularity that is only limited by the available memory space. Several implementation issues are also presented in this paper.
Hemin-coupled iron(III)-hydroxide nanoparticles show increased uptake in Caco-2 cells (2011)

Hemin-coupled iron(III)-hydroxide nanoparticles were carried by a heme specific transport system, probably via receptor mediated endocytosis. It can be expected that this system shows improved absorption of iron compared with uncoupled iron(III)-hydroxide nanoparticles, which exist on the market today.
Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century (2015)

Given the present realities, three future directions for research and intervention are suggested: (i) address the preventable causes of infertility, (ii) provide support and alternatives for the infertile and (iii) encourage new LCIVF initiatives to improve availability, affordability and acceptability of ART around the globe.
Form-birefringent computer-generated holograms (1996)

Polarization-selective computer-generated holograms made with form-birefringent nanostructures were designed, fabricated, and evaluated experimentally at 1.5 microm. The fabricated element showed a large polarization contrast ratio (>250:1) and a high diffraction efficiency (>40% for a binary phase level element). The experimental evaluation was in good agreement with the design and modeling predictions.
Lymphatic Drainage Imaging of Breast Cancer in Mice by Micro-Magnetic Resonance Lymphangiography Using a Nano-Size Paramagnetic Contrast Agent (2004)

The superior temporal and spatial resolution of micro-MR lymphangiography using the contrast agent G6 may facilitate the study of tumor lymphatic drainage and lymphatic metastasis in both experimental animals and clinical medicine. In addition, this may be a powerful new method for sentinel lymph node localization in human breast cancer.
“Miswak” Based Green Synthesis of Silver Nanoparticles: Evaluation and Comparison of Their Microbicidal Activities with the Chemical Synthesis (2016)

Microbicidal potential of silver nanoparticles (Ag-NPs) can be drastically improved by improving their solubility or wettability in the aqueous medium. In the present study, we report the synthesis of both green and chemical synthesis of Ag-NPs, and evaluate the effect of the dispersion qualities of as-prepared Ag-NPs from both methods on their antimicrobial activities. The green synthesis of Ag-NPs is carried out by using an aqueous solution of readily available <i>Salvadora persica</i> L. root extract (RE) as a bioreductant. The formation of highly crystalline Ag-NPs was established by various analytical and microscopic techniques. The rich phenolic contents of <i>S. persica</i> L. RE (Miswak) not only promoted the reduction and formation of NPs but they also facilitated the stabilization of the Ag-NPs, which was established by Fourier transform infrared spectroscopy (FT-IR) analysis. Furthermore, the influence of the volume of the RE on the size and the dispersion qualities of the NPs was also evaluated. It was revealed that with increasing the volume of RE the size of the NPs was deteriorated, whereas at lower concentrations of RE smaller size and less aggregated NPs were obtained. During this study, the antimicrobial activities of both chemically and green synthesized Ag-NPs, along with the aqueous RE of <i>S. persica</i> L., were evaluated against various microorganisms. It was observed that the green synthesized Ag-NPs exhibit comparable or slightly higher antibacterial activities than the chemically obtained Ag-NPs.
Processing, Mechanical and Optical Properties of Additive-Free ZrC Ceramics Prepared by Spark Plasma Sintering (2016)

In the present study, nearly fully dense monolithic ZrC samples are produced and broadly characterized from microstructural, mechanical and optical points of view. Specifically, 98% dense products are obtained by Spark Plasma Sintering (SPS) after 20 min dwell time at 1850 °C starting from powders preliminarily prepared by Self-propagating High-temperature Synthesis (SHS) followed by 20 min ball milling. A prolonged mechanical treatment up to 2 h of SHS powders does not lead to appreciable benefits. Vickers hardness of the resulting samples (17.5 ± 0.4 GPa) is reasonably good for monolithic ceramics, but the mechanical strength (about 250 MPa up to 1000 °C) could be further improved by suitable optimization of the starting powder characteristics. The very smoothly polished ZrC specimen subjected to optical measurements displays high absorption in the visible-near infrared region and low thermal emittance at longer wavelengths. Moreover, the sample exhibits goodspectral selectivity (2.1-2.4) in the 1000-1400 K temperature range. These preliminary results suggest that ZrC ceramics produced through the two-step SHS/SPS processing route can be considered as attractive reference materials for the development of innovative solar energy absorbers.