CD123 hiDendritic Cell Lymphoma: An Unusual Case of Non-Hodgkin Lymphoma (1999)

Letters5 October 1999CD123 hiDendritic Cell Lymphoma: An Unusual Case of Non-Hodgkin LymphomaPaulo Lúcio, MD, Antonio Parreira, and Alberto OrfaoPaulo Lúcio, MDPortuguese Institute of Oncology; Lisbon, Portugal (Lúcio)Portuguese Institute of Oncology; Lisbon, Portugal (Parreira)University of Salamanca; Salamanca, Spain (Orfao), Antonio ParreiraPortuguese Institute of Oncology; Lisbon, Portugal (Lúcio)Portuguese Institute of Oncology; Lisbon, Portugal (Parreira)University of Salamanca; Salamanca, Spain (Orfao), and Alberto OrfaoPortuguese Institute of Oncology; Lisbon, Portugal (Lúcio)Portuguese Institute of Oncology; Lisbon, Portugal (Parreira)University of Salamanca; Salamanca, Spain (Orfao)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-7-199910050-00035 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:A new hemopoietic-derived lineage of dendritic cells was recently reported; this lineage is characterized by a particularly high expression of the interleukin-3 receptor α-chain (CD123 hi) (1). Unlike Langerhans cells, normal CD123 hi dendridic cells migrate through peripheral blood to lymphoid tissues in the absence of inflammatory stimuli; they are found in fetal and adult lymph nodes, tonsils, and thymus. No tumoral counterpart of this dendritic cell subset has yet been identified.We describe a patient with a histopathologic diagnosis of non-Hodgkin lymphoma in whom immunophenotypic and molecular studies ruled out the B, T, or natural killer ...References1. Olweus J, BitMansour A, Warnke R, Thompson P, Carballido J, Picker L, et al . Dendritic cell ontogeny: a human dendritic cell lineage of myeloid origin. Proc Natl Acad Sci U S A. 1997;94:12551-6. CrossrefMedlineGoogle Scholar2. Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML, et al . A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood. 1994;84:1361-92. CrossrefMedlineGoogle Scholar3. Cabanillas F, Hagemeister FB, Bodey GP, Freireich EJ. IMVP16: an effective regimen for patients with lymphoma who have relapsed after initial combination chemotherapy. Blood. 1982;60:693-7. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Paulo Lúcio, MD; Antonio Parreira; Alberto OrfaoAffiliations: Portuguese Institute of Oncology; Lisbon, Portugal (Lúcio)Portuguese Institute of Oncology; Lisbon, Portugal (Parreira)University of Salamanca; Salamanca, Spain (Orfao) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoOn the Death of House Officers Faith Fitzgerald and T. 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