gebhart/patrepeval huggingface dataset:
Quantification of Internal Filtration in Hollow Fiber Hemodialyzers with Medium Cut-Off Membrane (2018)

MCO membrane provides significant amounts of IF due to the particular combination between hydraulic permeability of the membrane and reduced inner diameter of the fibers. High IF combined with enhanced sieving profile of MCO membrane leads to improved removal of a wider spectrum of uremia retention molecules in HDx, without requiring complex equipment.
Mig-6 Is a Negative Regulator of the Epidermal Growth Factor Receptor Signal (2001)

In contrast to signal generation and transmission, the mechanisms and molecules that negatively regulate receptor tyrosine kinase (RTK) signaling are poorly understood. Here we characterize Mig-6 as a novel negative feedback regulator of the epidermal growth factor receptor (EGFR) and potential tumor suppressor. Mig-6 was identified in a yeast two-hybrid screen with the kinase active domain of the EGFR as bait. Upon EGF stimulation Mig-6 binds to the EGFR involving a highly acidic region between amino acids 985-995. This interaction is kinase activity-dependent, but independent of tyrosine 992. Mig-6 overexpression results in reduced activation of the mitogenactivated protein kinase ERK2 in response to EGF, but not FGF or PDGF, stimulation and in enhanced receptor internalization without affecting the rate of degradation. The induction of Mig-6 mRNA expression in response to EGF, but not FGF, indicates the existence of a negative regulatory feedback loop. Consistent with these findings, a possible role as tumor suppressor is indicated by Mig-6-mediated inhibition of EGFR overexpression-induced transformation of Rati cells.
27-Gauge Transconjunctival Nonvitrectomizing Vitreous Surgery for Epiretinal Membrane Removal (2007)

SAKAGUCHI, HIROKAZU MD; OSHIMA, YUSUKE MD; TANO, YASUO MDEditor(s): Williams, George A. Author Information
Additional file 10: of Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus (2017)

CAZy comparison of the species. (XLSX 30 kb)
Low‐Cost Volumetric 3D Printing of High‐Precision Miniature Lenses in Seconds (2022)

Abstract 3D printing is a promising method for the generation of complex‐shaped optical components. However, the printing efficiency, form accuracy, and surface smoothness are still challenging, especially for the printing of optical components. In this study, by synergizing the volumetric projection stereolithography, meniscus equilibrium effect, and iterative learning scheme, a low‐cost volumetric 3D printing method is developed for the ultra‐fast and high‐precision fabrication of miniature lenses with sub‐nanometric roughness. By including the covered liquid film as a part of the printed lens in the iterative learning, a low form error at the micrometer scale is achieved for the printed lens without any prior knowledge of the 3D printing process. As a demonstration, a sphere lens at the millimeter scale is directly printed in 2 s, achieving a peak‐to‐valley profile error of less than 5 µm, a sub‐nanometric roughness of rms = 0.614 nm, and an imaging resolution of 203.2 lp mm −1 . It suggests that besides fast prototyping, the developed 3D printing strategy is suitable for the massive production of precise lenses.
Rapid Expansion of Highly Functional Antigen-Specific T Cells from Patients with Melanoma by Nanoscale Artificial Antigen-Presenting Cells (2020)

Peptide-pulsed nano-aAPC rapidly expanded polyfunctional antigen-specific CD8 T cells with high avidity, potent lytic function, and a stem cell memory phenotype from patients with melanoma.
First Demonstration of Crosstalk-Free (< -38.5 dB) 32-ch DWDM Demultiplexer on Standard Si PIC Platform (2022)

Enabled by a fully integrated autonomous calibration mechanism, crosstalk-free 32-ch WDM demultiplexer on standard Si PIC platform is demonstrated for the first time. Compatible with the vast component libraries of standard Si PIC platform, this device provides a path to ultrahigh-capacity integrated DWDM transceivers.
Balance Between Light Absorption and Recombination Losses in Solution‐Processed Small Molecule Solar Cells with Normal or Inverted Structures (2018)

Abstract Comparison of the photovoltaic properties of F3:fullerene bulk heterojunction solar cells (where F3 is a donor molecule of intermediate dimensions) with normal and inverted structures as a function of photoactive layer thickness is carried out by using optical modeling and light‐dependent photoelectrical characterization. The larger short circuit current of inverted devices can be explained by higher light absorption in the active layer, relative to normal devices. However, worse charge extraction conditions and trap‐assisted recombination, in the bulk heterojunction blend in inverted devices, give rise to larger nongeminate recombination losses and an opposite thickness dependence of the short circuit current and fill factor than what is observed in counterparts with the conventional device architecture.
PHOTOVOLTAIC MATERIALS (2012)

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Planare Bischlorophyllderivate mit vollständig konjugiertem π‐System ‐ Modellverbindungen für das Spezialpaar der Photosynthese (1996)

Bei der Titan‐induzierten Kupplung von Ni II ‐ und Zn II ‐Pyrophäophorbiden entstehen planare C=C‐verbrückte Bisphiophorbide 1 , M=Ni, Zn. Ihre Absorptionsspektren weisen auf eine starke Konjugation der beiden Chlorin‐Einheiten hin, und aus Kristallstrukturanalysen geht hervor, daß die beiden Phäophorbidringe beinahe coplanar sind. magnified image
Using a Bayesian Approach to Predict Patients' Health and Response to Treatment (2020)

s health and how well a treatment will work.
Enhancing the Response Time of Electrowetting Lenses Using Voltage Shaping (2017)

We have demonstrated tunability of the response time of electrowetting lenses from underdamped to overdamped through input voltage shaping. This strategy shows great promise to further optimize the response time of electrowetting lenses.
Mid-infrared difference-frequency generation in suspended GaAs waveguides (2014)

We experimentally demonstrate mid-infrared difference-frequency generation in suspended 181 nm thick GaAs waveguides. Generation of the idler at wavelengths between 2800 and 3150 nm is enabled by form-birefringent phase-matching in ultrahigh index-contrast waveguides. Nonlinear mixing has a measured efficiency of 0.4 W⁻¹ in a 1.2 mm long waveguide using a CW signal tunable between 1490 and 1620 nm and a CW pump tunable between 1018 and 1032 nm at powers of a few mW.
Hyperhomocysteinemia decreases intestinal motility leading to constipation (2012)

Elevated levels of plasma homocysteine (Hcy) called hyperhomocysteinemia (HHcy) have been implicated in inflammation and remodeling in intestinal vasculature, and HHcy is also known to aggravate the pathogenesis of inflammatory bowel disease (IBD). Interestingly, colon is the pivotal site that regulates Hcy levels in the plasma. We hypothesize that HHcy decreases intestinal motility through matrix metalloproteinase-9 (MMP-9)-induced intestinal remodeling leading to constipation. To verify this hypothesis, we used C57BL/6J or wild-type (WT), cystathionine β-synthase (CBS(+/-)), MMP-9(-/-), and MMP-9(-/-) + Hcy mice. Intestinal motility was assessed by barium meal studies and daily feces output. Plasma Hcy levels were measured by HPLC. Expression of ICAM-1, inducible nitric oxide synthase, MMP-9, and tissue inhibitors of MMPs was studied by Western blot and immunohistochemistry. Reactive oxygen species (ROS) including super oxide were measured by the Invitrogen molecular probe method. Tissue nitric oxide levels were assessed by a commercially available kit. Plasma Hcy levels in the treated MMP-9 group mice were comparable to CBS(+/-) mice. Barium meal studies suggest that intestinal motility is significantly decreased in CBS(+/-) mice compared with other groups. Fecal output-to-body weight ratio was significantly reduced in CBS(+/-) mice compared with other groups. There was significant upregulation of MMP-9, iNOS, and ICAM-1 expression in the colon from CBS(+/-) mice compared with WT mice. Levels of ROS, superoxide, and inducible nitric oxide were elevated in the CBS(+/-) mice compared with other groups. Results suggest that HHcy decreases intestinal motility due to MMP-9-induced intestinal remodeling leading to constipation.
Shape and Form Optimization of On-Line Pressure-Compensating Drip Emitters to Achieve Lower Activation Pressure (2017)

This study presents the design and validation of on-line pressure-compensating (PC) drip irrigation emitters with a substantially lower minimum compensating inlet pressure (MCIP) than commercially available products. A reduced MCIP, or activation pressure, results in a drip irrigation system that can operate at a reduced pumping pressure, has lower power and energy requirements, requires a lower initial capital cost, and facilitates solar-powered irrigation systems. The technology presented herein can help spread drip irrigation to remote regions and contribute to reducing poverty, particularly in developing countries. The activation pressures of drip emitters at three flow rates were minimized using a genetic algorithm (GA)-based optimization method coupled with a recently published fluid–structure interaction analytical model of on-line PC drip emitter performance. The optimization took into account manufacturing constraints and the need to economically retrofit existing machines to manufacture new emitters. Optimized PC drip emitter designs with flow rates of 3.3, 4.2, and 8.2 lph were validated using precision machined prototype emitters. The activation pressure for all was ≤0.2 bar, which is as low as 16.7% that of commercial products. A limited production run of injection molded 8.2 lph dripper prototypes demonstrated they could be made with conventional manufacturing techniques. These drippers had an activation pressure of 0.15 bar. A cost analysis showed that low MCIP drip emitters can reduce the cost of solar-powered drip irrigation systems by up to 40%.
A Study of Establishing Converged Service R&D Infrastructure (2014)

Service R&D that adds high value to existing products and service by scientification, IT convergence, intellectualization is a core business of creative economy. It is necessary to examine the service R&D revitalization plan by establishing service R&D hub researching the service R&D because a shortage of facility and infrastructure makes impossible to turn ideas into products (service). This research aims at establishing the implementation plan of service R&D hub that invigorates local service industries and contributes to carry out the plan. Service R&D hub is a focal point of service R&D activities which inter-connects service R&D activities distributed across ministries of central government and fields of studies, and which invigorates service R&D activities and enhances competitive power of service industries in Korea. It is necessary to establish main hub like Service Engineering Research Center in Japan and Fraunhofer IAO in Germany which take the lead in national service R&D activities, and make it build the solid foundation of service R&D activities in public sector and also create service innovation ecosystem. Considering the interdisciplinary characters of service R&D, it is essential to establish additional sub-hubs to meet a variety of demands of service R&D. It is also necessary to establish 'Living Lab', an open innovation system, which connects research institutions, universities, and corporates to make them target the specific fields of their own, and enhance open R&D and innovation in service industries.
Estimation and detection in non-Gaussian noise using higher order statistics (1994)

One of the primary applications of higher order statistics has been for detection and estimation of nonGaussian signals in Gaussian noise of unknown covariance. This is motivated by the fact that higher order cumulants of Gaussian processes vanish. We study the opposite problem, namely, detection and estimation in nonGaussian noise. We estimate cumulants of nonGaussian processes in the presence of unknown deterministic and/or Gaussian signals, which allows either parametric or nonparametric estimation of the covariance of the nonGaussian noise. Our approach is to augment existing second-order detection methods using cumulants. We propose solutions for detection of deterministic signals based on matched filters and the generalized likelihood ratio test which incorporate cumulants, where the resulting solutions are valid under either detection hypotheses. This allows for single record detection and obviates the need for noise-only training records. The problem of estimating signal strength in the presence of nonGaussian noise of unknown covariance is also considered, and a cumulant-based solution is proposed which uses a single data record. Examples are used throughout to illustrate our proposed methods.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The Root Extract of Gentiana macrophylla Pall. Alleviates Cardiac Apoptosis in Lupus Prone Mice (2015)

The roots of the perennial herb Gentiana macrophylla Pall. (GM) are known as Qinjiao, which has been used for centuries to treat systemic lupus erythematosus (SLE). However, little is known about the effects of GM on cholesterol-aggravated cardiac abnormalities in SLE, and the mechanisms thereof. This study investigates whether GM exhibits anti-apoptotic effects, focusing on the left ventricle (LV) of NZB/W F1 mice fed with high-cholesterol diet. The morphology and apoptotic status of ventricular tissues were determined by microscopy and Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Levels of apoptotic biomarkers were determined by immunoblotting. The results thus obtained revealed that GM significantly reduced the cholesterol-aggravated apoptosis of LV in NZB/W F1 mice by suppressing both intrinsic and extrinsic apoptotic pathways. Additionally, GM significantly increased the cardiac insulin-like growth factors (IGF)-1 survival signaling and anti-apoptotic proteins in LV tissues. Accordingly, GM is considered to be beneficial in alleviating cholesterol-aggravated cardiac damage in SLE, and therefore constitute an alternative treatment for SLE patients with cardiac abnormalities.
Targeted Antireceptor Therapy with Monoclonal Antibodies Leads to the Formation of Inactivated Tetrameric Forms of ErbB Receptors (2007)

mAbs capable of disabling heterodimeric kinase complexes of the epidermal growth factor receptor (EGFR) and human EGFR type 2/neu have therapeutic relevance to various human cancers. In this study, we demonstrate that in addition to the dimer, EGFR and human EGFR type 2 can associate as homo- and heterotetramers. EGF-induced phosphorylation of the tetramers was significantly lower than that of the dimers, indicating that the tetrameric receptor complexes have impaired signaling activity. Targeting v-erb-b2 erythroblastic leukemia viral oncogene homolog (erbB) receptors with mAbs promoted erbB tetrameric assembly, suggesting that a component of the antitumor activity may be mediated by the ability of Abs to shift the equilibrium from active dimeric to impaired tetrameric receptor complex states. This study suggests a novel therapeutic approach to disable signaling of erbB and potentially other receptors in tumors by biologic agents capable of inducing receptor tetramerization.
Properties of a U1 RNA enhancer-like sequence (1987)

The properties of a X.laevis U1B snRNA gene enhancer have been studied by microinjection in Xenopus oocytes. The enhancer-like sequence, defined as a short DNA stretch that is able to activate transcription in an orientation independent manner, is interchangeable between different U snRNA genes. The enhancer sequence alone does not, however, efficiently activate transcription from an SV40 pol II promoter but regains its activity when combined with the U-gene specific proximal sequence element. DNase I protection experiments show that the X.laevis U1B enhancer can interact specifically with a nuclear factor present in mammalian cells.
A quantitative study of accuracy in system call-based malware detection (2012)

Over the last decade, there has been a significant increase in the number and sophistication of malware-related attacks and infections. Many detection techniques have been proposed to mitigate the malware threat. A running theme among existing detection techniques is the similar promises of high detection rates, in spite of the wildly different models (or specification classes) of malicious activity used. In addition, the lack of a common testing methodology and the limited datasets used in the experiments make difficult to compare these models in order to determine which ones yield the best detection accuracy. In this paper, we present a systematic approach to measure how the choice of behavioral models influences the quality of a malware detector. We tackle this problem by executing a large number of testing experiments, in which we explored the parameter space of over 200 different models, corresponding to more than 220 million of signatures. Our results suggest that commonly held beliefs about simple models are incorrect in how they relate changes in complexity to changes in detection accuracy. This implies that accuracy is non-linear across the model space, and that analytical reasoning is insufficient for finding an optimal model, and has to be supplemented by testing and empirical measurements.
A Review of Turbine Blade Tip Heat Transfer (2001)

This paper presents a review of the publicly available knowledge base concerning turbine blade tip heat transfer, from the early fundamental research which laid the foundations of our knowledge, to current experimental and numerical studies utilizing engine-scaled blade cascades and turbine rigs. Focus is placed on high-pressure, high-temperature axial-turbine blade tips, which are prevalent in the majority of today's aircraft engines and power generating turbines. The state of our current understanding of turbine blade tip heat transfer is in the transitional phase between fundamentals supported by engine-based experience, and the ability to a priori correctly predict and efficiently design blade tips for engine service.
Acid-Resistant Microfine Squeeze Cement: From Conception to Viable Technology (1993)

Abstract This paper focuses on the development and field application of an acid resistant, microfine portland cement composition. This specialized cementing system has been developed for remedial water and/or gas shut-off squeeze operations in the Prudhoe Bay Field of Alaska. Because of the unique properties of microfine cements and the requirements of this application, new laboratory and field test procedures have been introduced. A full-scale mixing and pumping test was conducted prior to field application of the new Portland cement system. This testing was performed to ensure proper performance of the cement in a field environment. Slurry properties after mixing and pumping through 17,300 ft. of coiled tubing are presented. To better illustrate the sequence of lessons learned, several case histories and prior microfine cement designs are discussed.
Enteroviral Infection: The Forgotten Link to Amyotrophic Lateral Sclerosis? (2018)

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that primarily attacks motor neurons in the brain and spinal cord, leading to progressive paralysis and ultimately death. Currently there is no effective therapy. The majority of ALS cases are sporadic, with no known family history; unfortunately the etiology remains largely unknown. Contribution of Enteroviruses (EVs), a family of positive-stranded RNA viruses including poliovirus, coxsackievirus, echovirus, enterovirus-A71 and enterovirus-D68, to the development of ALS has been suspected as they can target motor neurons, and patients with prior poliomyelitis show a higher risk of motor neuron disease. Multiple efforts have been made to detect enteroviral genome in ALS patient tissues over the past two decades; however the clinical data are controversial and a causal relationship has not yet been established. Recent evidence from <i>in vitro</i> and animal studies suggests that enterovirus-induced pathology remarkably resembles the cellular and molecular phenotype of ALS, indicating a possible link between enteroviral infection and ALS pathogenesis. In this review, we summarize the nature of enteroviral infection, including route of infection, cells targeted, and viral persistence within the central nervous system (CNS). We review the molecular mechanisms underlying viral infection and highlight the similarity between viral pathogenesis and the molecular and pathological features of ALS, and finally, discuss the potential role of enteroviral infection in frontotemporal dementia (FTD), a disease that shares common clinical, genetic, and pathological features with ALS, and the significance of anti-viral therapy as an option for the treatment of ALS.
Characteristics of two idiotypic subfamilies of murine anti-p-azobenzenearsonate antibodies. (1987)

A family of antibodies bearing a common or cross-reactive idiotype, termed CRIC, predominates in the response of most BALB/c mice to the p-azobenzenearsonate (Ar) hapten, but represents a minor component of the anti-Ar response of most A/J mice. Previous results have suggested that the VH region of CRIC is encoded by two different germ-line genes in both strains. We have determined extensive mRNA sequences for VH and VL, developed specific idiotypic reagents and measured affinities for two subfamilies of CRIC, designated CRIC1 and CRIC2. Both were found to be minor components of A/J anti-Ar antibodies, and CRIC1, but not CRIC2, is a major component of the BALB/c response. The two subfamilies utilize different VH germ-line genes but the same, or nearly identical V kappa genes. The VH nucleotide sequences of CRIC1 and CRIC2 exhibit approximately 90% homology. The D regions of both families are short (one or two amino acid residues) and some can be accounted for on the basis of known JH sequences alone. Affinity differences may account for the dominance of CRIA over CRIC1 and CRIC2 in A/J mice, but results obtained with allotype-congenic mice indicate that background (non-V region) genes are also important in controlling levels of expression of the CRIC1 idiotype. Our data suggest that the A/J germline VH gene that gives rise to the CRIC2 family of antibodies may be identical with a previously sequenced BALB/c germ-line VH gene. On the basis of these and earlier data it is suggested that extensive differences between inbred strains of mice in their complements of VH genes do not result from the accumulation of many mutations in these genes. An alternative possibility is that the differences arise from deletions and/or duplications of VH genes.