gebhart/patrepeval huggingface dataset:
Polymer-supported zirconocene catalyst for ethylene polymerization (1999)

The use of crosslinked poly(styrene-co-4-vinylpyridine) having functional groups as the support for zirconocene catalysts in ethylene polymerization was studied. Several factors affecting the activity of the catalysts were examined. Conditions like time, temperature, Al/N (molar ratio), Al/Zr (molar ratio), and the mode of feeding were found having no significant influence on the activity of the catalysts, while the state of the supports had a great effect on the catalytic behavior. The activity of the catalysts sharply increased with either the degree of crosslinking or the content of 4-vinylpyridine in the support. Via aluminum compounds, AlR3 or methylaluminoxane (MAO), zirconocene was attached on the surface of the support. IR spectra showed an intensified and shifted absorption bands of CN in the pyridine ring, and a new absorption band appeared at about 730 cm−1 indicating a stable bond AlN formed in the polymer-supported catalysts. The formation of cationic active centers was hypothesized and the performance of the polymer-supported zirconocene was discussed as well. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 37–46, 1999
Location Control of Si Thin-Film Grain Using Ni Imprint and Excimer Laser Annealing (2006)

A novel method of locating Si crystal grains by combining Ni imprint and excimer laser annealing (ELA) is demonstrated. Ni imprint is used for the purpose of creating Si crystal nuclei that act as the seed for the subsequent crystallization by ELA. Two Ni-imprint processes were investigated; (1) Ni imprint at the SiO2 substrate surface followed by the deposition of amorphous Si (a-Si), and (2) a-Si deposition on the SiO2 substrate followed by Ni imprint at the a-Si film surface. The annealing used to form nuclei at the imprinted sites was carried out at temperatures below 450 °C. XeCl-laser-based ELA of the sample thus prepared resulted in the formation of about 2 µm sized Si grains at the imprinted sites, whereas the grain consists of several sub-grains radially grown from the center of the grain. The application of Secco's etching to the location-controlled grains formed by Ni imprint at the SiO2 substrate delineated a cavity at the middle of the grain, whereas no cavity was observed in the grains formed by Ni imprint at the a-Si surface. Thus, Ni imprint at the a-Si surface produces higher-quality Si grains than Ni imprint at the SiO2 substrate surface. Details of the experimental conditions used to create the location-controlled grains are described.
Monitoring periodontal disease status in smokers and nonsmokers using a gingival crevicular fluid matrix metalloproteinase‐8‐specific chair‐side test (2006)

Persistently elevated GCF MMP-8 concentrations may indicate sites at risk, as well as patients with poor response to conventional periodontal treatment (e.g. SRP). MMP-8 testing may be useful as an adjunct to traditional periodontal diagnostic methods during the maintenance phase.
EMC and BEM Engineering Education: P hysics-Based Modeling, (2003)

Educational challenges in EMC-BEM engineering and related issues are discussed in this paper. The importance of physics- based modeling and hands-on training are emphasized. Characteristic cases in EMC tests, measurements, modeling, and simulation are presented. Finally, some suggestions and a short-course outline are given for modern EMC-BEM education.
Learning in dynamic environments with Ensemble Selection for autonomous outdoor robot navigation (2008)

Autonomous robot navigation in unstructured outdoor environments is a challenging area of active research. The navigation task requires identifying safe, traversable paths which allow the robot to progress toward a goal while avoiding obstacles. Machine learning techniques - in particular, classifier ensembles - are well adapted to this task, accomplishing near-to-far learning by augmenting near-field stereo readings in order to identify safe terrain and obstacles in the far field. Composition of the ensemble and subsequent combination of model outputs in this dynamic problem domain remain open questions. Recently, Ensemble selection has been proposed as a mechanism for selecting and combining models from an existing model library and shown to perform well in static domains. We propose the adaptation of this technique to the time-evolving data associated with the outdoor robot navigation domain. Important research questions as to the composition of the model library, as well as how to combine selected modelspsila outputs, are addressed in a two-factor experimental evaluation. We evaluate the performance of our technique on six fully labeled datasets, and show that our technique outperforms memoryless baseline techniques that do not leverage past experience.
Electronically conducting ceramic electron conductor material and the process for producing an air-tight seal in an oxygen sensor with an internal reference (2023)

A method and an article of an electrically conductive ceramic interconnect bonded to a compatible ceramic housing for an oxygen partial pressure sensor system. The interconnect includes a LaxSryAlzMn1−zO3 (LSAM) having a stoichiometry enabling good electrical conductivity at high temperatures and the LSAM also bonded to a yttria stabilized zirconia forming a stable and durable seal.
A circuit mechanism for differentiating positive and negative associations (2015)

Neurons in the basolateral amygdala projecting to canonical fear or reward circuits undergo opposing changes in synaptic strength following fear or reward conditioning, and selectively activating these projection-target-defined neural populations causes either negative or positive reinforcement, respectively.
Acoustics education accelerated by interactive simulators and research imaging system experiments (2021)

Learning acoustics traditionally involves abstract principles, equations and a limited number of specific exercises. We have developed an eight module introductory course in which students can engage with the ultrasound imaging curriculum experientially by interacting with real time GUI-based physics simulators. With only an introduction to the concepts, students with minimal mathematical background can quickly understand how the principles work by varying different simulator parameters over a wide range of examples and observing the output changes. Advanced students who know the simulator equations can learn the subtle interplay of different variables on outcomes on a deeper level. These simulators accelerate learning even more when the equations involve complicated integrals or equations which have to be evaluated numerically. Display options offer different ways of visualizing the acoustic and image data. Laboratories using a Verasonics ultrasound research imaging system provide hands-on learning of signal processing, transducer operation, and image processing.
covidscreen: a web app and R Package for assessing asymptomatic COVID-19 testing strategies (2022)

As the COVID-19 pandemic continues to evolve, covidscreen can assist organizations in making informed decisions about whether to incorporate covid test based screening as part of their on-campus risk-mitigation strategy. The web application, R package, and source code are freely available online (see "Availability of data and materials").
[Sequential monitoring of plasma EBV-DNA level in a patient with EBV-positive Hodgkin lymphoma]. (2012)

A 58-year-old woman was admitted to our hospital because of fever, systemic lymphadenopathy with abnormal Epstein-Barr virus (EBV) antibody titers, and a high EBV-DNA load in the serum. She had been diagnosed as possibly having chronic active EBV infection (CAEBV) during a previous hospitalization. The EBV-DNA load of the plasma (pEBV-DNA), examined at our hospital, was elevated to 1.8×10(4) copies/ml, whereas that of the peripheral blood mononuclear cells was 3.4×10(1) copies/μg DNA, which was not clearly elevated, unlike in cases with CAEBV. Biopsy of the cervical lymph node was performed and the diagnosis of mixed cellularity classical Hodgkin lymphoma, Stage4B was made. Hodgkin cells were positive for EBV. COPP therapy was started and pEBV-DNA decreased drastically. The treatment was followed by ABVD therapy and pEBV-DNA turned negative after one course of ABVD therapy. She achieved complete response after 4 courses of the treatment. Reports from abroad indicate that pEBV-DNA parallels the disease state of EBV-positive Hodgkin lymphoma. Our results were consistent with these reports, and demonstrated that, in a Japanese patient, EBV-DNA load and its localization in the peripheral blood fractions could be useful tools for diagnosis as well as evaluating the disease status.
The effect of nipradilol, an a-ß blocker, on retinal blood flow in healthy volunteers (2001)

Topical nipradilol significantly increased retinal arterial blood flow in healthy volunteers, not through a secondary effect dependent on a change in OPP, but likely through the vasodilatory action of the drug.
ChemInform Abstract: Conformational Mimicry. Part 1. 1,5‐Disubstituted Tetrazole Ring as a Surrogate for the Cis Amide Bond. (1988)

ChemInformVolume 19, Issue 49 Natural Products ChemInform Abstract: Conformational Mimicry. Part 1. 1,5-Disubstituted Tetrazole Ring as a Surrogate for the Cis Amide Bond. J. ZABROCKI, J. ZABROCKI Dep. Pharmacol., Washigton Univ. Sch. Med., St. Louis, MO 63110, USASearch for more papers by this authorG. D. SMITH, G. D. SMITH Dep. Pharmacol., Washigton Univ. Sch. Med., St. Louis, MO 63110, USASearch for more papers by this authorJ. B. JUN. DUNBAR, J. B. JUN. DUNBAR Dep. Pharmacol., Washigton Univ. Sch. Med., St. Louis, MO 63110, USASearch for more papers by this authorH. IIJIMA, H. IIJIMA Dep. Pharmacol., Washigton Univ. Sch. Med., St. Louis, MO 63110, USASearch for more papers by this authorG. R. MARSHALL, G. R. MARSHALL Dep. Pharmacol., Washigton Univ. Sch. Med., St. Louis, MO 63110, USASearch for more papers by this author J. ZABROCKI, J. ZABROCKI Dep. Pharmacol., Washigton Univ. Sch. Med., St. Louis, MO 63110, USASearch for more papers by this authorG. D. SMITH, G. D. SMITH Dep. Pharmacol., Washigton Univ. Sch. Med., St. Louis, MO 63110, USASearch for more papers by this authorJ. B. JUN. DUNBAR, J. B. JUN. DUNBAR Dep. Pharmacol., Washigton Univ. Sch. Med., St. Louis, MO 63110, USASearch for more papers by this authorH. IIJIMA, H. IIJIMA Dep. Pharmacol., Washigton Univ. Sch. Med., St. Louis, MO 63110, USASearch for more papers by this authorG. R. MARSHALL, G. R. MARSHALL Dep. Pharmacol., Washigton Univ. Sch. Med., St. Louis, MO 63110, USASearch for more papers by this author First published: December 6, 1988 https://doi.org/10.1002/chin.198849272AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume19, Issue49December 6, 1988 RelatedInformation
Unmodified pancreatic islet allograft rejection results in the preferential expression of certain T cell activation transcripts (1993)

Polymerase chain reaction-assisted reverse transcription was used to study the temporal course of rejection in unmodified recipients of murine pancreatic islet cell allografts (DBA/2-->B6AF1) by using syngeneic tissues as controls. The histologic appearance of the grafts was analyzed in parallel. Preproinsulin and constant region of the TCR-beta chain transcripts were studied as markers of graft integrity and infiltrating T cell mass, respectively. The participation of certain cytokines and CTL were analyzed by the detection of IL-2, IFN-gamma, IL-4, and CTL-specific serine protease (granzyme B) transcripts. The time-related disappearance of intragraft preproinsulin transcripts correlated with graft destruction, whereas the intensity of intragraft TCR-beta chain transcript levels correlated with the magnitude of mononuclear leukocyte infiltration in allografts. In unmodified allografts, the magnitude of IL-2 and IFN-gamma intragraft mRNA levels correlated with the intense mononuclear leukocyte infiltrate found on histologic examination at day 8. Only after stable IL-2 gene transcription on day 8 does evidence of graft destruction become apparent, indicating that IL-2 gene activation is closely related to and probably required for expression of alloimmune cytopathic processes. In contrast, IL-4 transcripts were absent or detected in low copy number throughout this time course. Intragraft expression of granzyme B mRNA, a CTL-specific transcript, peaked from day 8 to day 12 in allografts compared with syngeneic grafts or normal tissue. In syngeneic grafts IL-2 and/or IL-4 mRNA was essentially not detected. Although IFN-gamma and granzyme B transcripts were detected in syngeneic grafts, after 4 days the levels of detected transcripts were far less than those noted in allografts. In vivo detection of intragraft IL-2 transcripts in the relative absence of detectable IL-4 transcripts strongly suggests IL-2-dependent immune effector mechanisms are associated with, and perhaps responsible, for allograft rejection. Apparently IL-4-dependent effector mechanisms are not necessary for allograft rejection.
Phase 1 Study of a Recombinant Mutant Protective Antigen of Bacillus anthracis (2011)

A phase 1 study of a recombinant mutant protective antigen (rPA) vaccine was conducted in 186 healthy adults aged 18 to 45 years. Volunteers were randomized to receive one of three formulations of rPA (formalin treated, alum adsorbed, or both), in 10- or 20-μg dosages each, or the licensed vaccine, AVA. Three injections were given at 2-month intervals and a 4th 1 year after the 3rd. Vaccinees were examined at the clinic once following each injection, at 48 to 72 h postinjection. Adverse reactions were recorded in diaries for 7 days. Sera were collected before each injection and 1 week after the 1st, 2 weeks after the 3rd and 4th, and 1 year after the 4th. Serum anti-PA IgG was assayed by enzyme-linked immunosorbent assay (ELISA) and toxin neutralization assay (TNA). All formulations at both dosages were safe and immunogenic, inducing booster responses, with the highest antibody levels following the 4th injection (354 to 732 μg/ml). The lowest levels were induced by the formalin-only-treated rPA; there was no statistical difference between levels induced by alum-adsorbed and formalin-treated/alum-adsorbed rPA or by the two dosages. The antibody levels declined in all groups during the 1-year intervals after the 3rd and 4th injections but less so during the 2nd year, after the 4th injection (fold decreases were 10 to 25 versus 3.4 to 7.0, P < 0.001). There were too few AVA recipients for statistical comparisons, but their antibody levels followed those of rPA. Anti-rPA measured by ELISA correlated with TNA titers (r = 0.97). These data support studying alum-adsorbed rPA in children.
Selective expression of inhibitory Fcγ receptor by metastatic melanoma impairs tumor susceptibility to IgG‐dependent cellular response (2008)

During melanoma progression, patients develop anti-tumor immunity including the production of anti-tumor antibodies. Although the strategies developed by malignant cells to escape anti-tumor cellular immunity have been extensively investigated, little is known about tumor resistance to humoral immunity. The main effect of IgG antibodies is to activate the immune response by binding to host Fc gamma receptors (FcgammaR) expressed by immune cells. We previously reported in a limited study that some human metastatic melanoma cells ectopically express the FcgammaRIIB1, an inhibitory isoform of FcgammaR. By analyzing a large panel of different types of human primary and metastatic solid tumors, we report herein that expression of FcgammaRIIB is restricted to melanoma and is acquired during tumor progression. We show that FcgammaRIIB expression prevents the lysis of human metastatic melanoma cells by NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC) in vitro, independently of the intracytoplasmic region of FcgammaRIIB. Using experimental mouse models, we demonstrate that expression of FcgammaRIIB protects B16F0 melanoma tumors from the ADCC induced by monoclonal and polyclonal anti-tumor IgG in vivo. Thus, our results identify FcgammaRIIB as a marker of human metastatic melanoma that impairs the tumor susceptibility to FcgammaR-dependent innate effector responses.
ChemInform Abstract: An Efficient Reduction of Azides to Amines: Synthesis of DNA Interactive Pyrrolo[2,1‐c][1,4]benzodiazepines. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The multiplexing gain of wireless networks (2005)

At high SNR the capacity of a point-to point MIMO system with N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> transmit antenna and N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">R</sub> receive antenna is min{N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> , N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">R</sub> } log(SNR) + O(1). The factor in front of the log is called the multiplexing gain. In this paper we consider a network with 2N nodes (N source destination pairs) that each have only a single antenna. These single antenna nodes could cooperate to form larger virtual arrays, usually called cooperative diversity, user cooperation, or coded cooperation. The question we ask is: how large a multiplexing gain is possible. We prove that for N = 2 the multiplexing gain is 1, and consider generalizations to larger networks
Recombination Rate Heterogeneity within Arabidopsis Disease Resistance Genes (2020)

Meiotic crossover frequency varies extensively along chromosomes and is typically concentrated in hotspots. As recombination increases genetic diversity, hotspots are predicted to occur at immunity genes, where variation may be beneficial. A major component of plant immunity is recognition of pathogen Avirulence (Avr) effectors by resistance (R) genes that encode NBS-LRR domain proteins. Therefore, we sought to test whether NBS-LRR genes would overlap with meiotic crossover hotspots using experimental genetics in Arabidopsis thaliana. NBS-LRR genes tend to physically cluster in plant genomes; for example, in Arabidopsis most are located in large clusters on the south arms of chromosomes 1 and 5. We experimentally mapped 1,439 crossovers within these clusters and observed NBS-LRR gene associated hotspots, which were also detected as historical hotspots via analysis of linkage disequilibrium. However, we also observed NBS-LRR gene coldspots, which in some cases correlate with structural heterozygosity. To study recombination at the fine-scale we used high-throughput sequencing to analyze ~1,000 crossovers within the RESISTANCE TO ALBUGO CANDIDA1 (RAC1) R gene hotspot. This revealed elevated intragenic crossovers, overlapping nucleosome-occupied exons that encode the TIR, NBS and LRR domains. The highest RAC1 recombination frequency was promoter-proximal and overlapped CTT-repeat DNA sequence motifs, which have previously been associated with plant crossover hotspots. Additionally, we show a significant influence of natural genetic variation on NBS-LRR cluster recombination rates, using crosses between Arabidopsis ecotypes. In conclusion, we show that a subset of NBS-LRR genes are strong hotspots, whereas others are coldspots. This reveals a complex recombination landscape in Arabidopsis NBS-LRR genes, which we propose results from varying coevolutionary pressures exerted by host-pathogen relationships, and is influenced by structural heterozygosity.
Continuous Synthesis Process of Hexagonal Nanoplates of P6m Ordered Mesoporous Silica (2011)

Hexagonally ordered mesoporous silica coined COK-12 was synthesized in a continuous process by combining streams of sodium silicate and citric acid/sodium citrate buffered solution of (ethylene oxide)(20)-(propylene oxide)(70)-(ethylene oxide)(20) triblock copolymer (Pluronic P123) from separate reservoirs. COK-12 precipitated spontaneously upon combining both streams at nearly neutral pH and ambient temperature. Stable intermediates of the COK-12 formation process could be prepared by limiting sodium silicate addition. Investigation of these intermediates using small-angle X-ray scattering revealed COK-12 formed via an assembly process departing from spherical uncharged core-shell P123-silica micelles. The sterical stabilization of these micelles decreased upon accumulation of silicate oligomers in their shell. Aggregation of the spherical micelles led to cylindrical micelles, which aligned and adopted the final hexagonal organization. This unprecedentedly fast formation of P6m ordered mesoporous silica was caused by two factors in the synthesis medium: the neutral pH favoring uncharged silicate oligomers and the high salt concentration promoting hydrophobic interactions with surfactant micelles leading to silica accumulation in the PEO shell. The easy continuous synthesis process is convenient for large-scale production. The platelet particle morphology with short and identical internal channels will be advantageous for many applications such as pore replication, nanotube or fiber growth, catalytic functionalization, drug delivery, film and sensor development, and in nano dyes as well as for investigation of pore diffusion phenomena.
Figure S5 from A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2′-Deoxycytidine (2023)

&lt;p&gt;Effects of KDM5i and DAC on enhancers and de novo super-enhancers&lt;/p&gt;
Bringing 3D and quantitative data in flexible endoscopy (2014)

In a near future, the computation power will be widely used in endoscopy rooms. It will enable the augmented reality already implemented in some surgery. Before reaching this, a preliminary step is the development of a 3D reconstruction endoscope. In addition to that, endoscopists suffer from a lack of quantitative data to evaluate dimensions and distances, notably for the polyp size measurement. In this thesis, a contribution to more a robust 3D reconstruction endoscopic device is proposed. Structured light technique is used and implemented using a diffractive optical element. Two patterns are developed and compared: the first is based on the spatial-neighbourhood coding strategy, the second on the direct-coding strategy. The latter is implemented on a diffractive optical element and used in an endoscopic 3D reconstruction device. It is tested in several conditions and shows excellent quantitative results but the robustness against bad visual conditions (occlusions, liquids, specular reflection,) must be improved. Based on this technology, an endoscopic ruler is developed. It is dedicated to answer endoscopists lack of measurement system. The pattern is simplified to a single line to be more robust. Quantitative data show a sub-pixel accuracy and the device is robust in all tested cases. The system has then been validated with a gastroenterologist to measure polyps. Compared to literature in this field, this device performs better and is more accurate.