gebhart/patrepeval huggingface dataset:
An Acoustic Hemostasis Device for Acute Arterial Bleeding (2004)

Abstract : This report summarizes research efforts conducted under the ONR grant entitled An Acoustic Hemostasis Device for Acute Arterial Bleeding, Lawrence Crum, Principal Investigator. The revised scope of effort concentrated on four tasks: Bleeding Detection, Therapy Delivery, Systems Design and Development, and Animal Testing of Systems. The revised performance period was 19 February 2002 - 31 December 2003.
Data Supplement from BET Protein Antagonist JQ1 Is Synergistically Lethal with FLT3 Tyrosine Kinase Inhibitor (TKI) and Overcomes Resistance to FLT3-TKI in AML Cells Expressing FLT-ITD (2023)

&lt;p&gt;Supplemental Figure 1: Chemical structures the agents utilized in the study. Supplemental Table 1: Clinical presentation and mutational status of the primary AML samples. Supplemental Figure 2: BET protein antagonist and FLT3-TKI induces apoptosis of AML cells. Supplemental Figure 3: BET protein antagonist is synergistic with FLT3-TK inhibitors. Supplemental Figure 4: I-BET151 and FLT3-TKI is synergistic in FLT3-ITD expressing AML. Supplemental Figure 5: JQ1 and ponatinib or AC220 is synergistic against primary AML cells. Supplemental Figure 6: JQ1 and FLT3-TKI does not deplete FLT3 phosphorylation. Supplemental Table 2: Comparison of MOLM13 and MOLM13-TKIR response to anti-leukemia agents. Supplemental Figure 7: Effects of JQ1 and FLT3-TKI treatment in MOLM13-TKIR cells. Supplemental Figure 8: Knockdown of BRD4 enhances sensitivity to JQ1 in MOLM13-TKIR cells. Supplemental Figure 9: JQ1 and panobinostat is synergistic against MV4-11 TKIR cells.&lt;/p&gt;
System performance challenges of IMT-Advanced test environments (2009)

The test environments for system level evaluations of IMT-A (International Mobile Telecommunications-Advanced) candidate technologies are analyzed. Compared to the evaluation criteria for previous IMT standards, the IMT-A test environments provide significantly more realistic settings for evaluating system-level performance. The models include line-of-sight probability in all scenarios, different groups of users in terms of propagation and speed, as well as indoor and outdoor deployments. This contribution scrutinizes the evaluation conditions and presents resulting performance for a basic Long-Term Evolution (LTE) candidate system. Each environment contains challenging characteristics. Examples include a mix of indoor and outdoor users, a mix of line-of-sight and non-line-of-sight conditions, and terminal speeds making accurate tracking of channel quality difficult. Together, these characteristics suggest that a radio transmission technology fulfilling the ITU IMT-A requirements is well suited for meeting a variety of challenges of real deployment scenarios.
Potential antitumor agents. 44. Synthesis and antitumor activity of new classes of diacridines: importance of linker chain rigidity for DNA binding kinetics and biological activity (1985)

Four classes of diacridines, joined at the 9-position by linker chains of varying length, rigidity, and polarity, were evaluated for DNA-binding properties and antitumor activity. Diacridines linked by flexible chains of varying polarity show relatively fast chromophore exchange kinetics among DNA binding sites but slower dissociation rates, suggesting the potential for considerable "creeping" of the drug along the helix, and are inactive in vivo. The exchange kinetics can be slowed dramatically by inclusion of positive charges in the side chain, but the resulting polycationic drugs are inactive in vivo, possibly due to poor distribution. Diacridines linked by a rigid, polar but neutral dicarbamoylpyrazole chain retain slow exchange kinetics, have a greatly reduced potential "creep rate", and possess good in vitro potency and significant in vivo antileukemic activity.
PRESSÃO DO GÁS DE TRABALHO COMO PARÂMETRO DE CONTROLE DE FASES CRISTALINAS OBTIDAS EM NITRETAÇÃO POR PLASMA PULSADO (2018)

Este trabalho apresenta resultados experimentais que indicam a possibilidade de selecionar a fase cristalina obtida com nitretaÃ§Ã£o por plasma pulsado, permitindo-se escolher entre a camada monofÃ¡sica Îµ-Fe2-3N e/ou Î³â-Fe4 N na camada branca. Os experimentos foram realizados em amostras de aÃ§o baixo carbono AISI 1015, tratadas com plasma em atmosfera N2 /H2 , em pressÃµes entre 100Pa e 1400Pa numa temperatura de 500Â°C. Foram aplicados pulsos bipolares de tensÃ£o de curta duraÃ§Ã£o em frequÃªncia de 125kHz (pulsos negativos com duraÃ§Ã£o de 7,5 Î¼s intercalados a pulsos positivos de 0,5 Î¼s). As amostras foram caracterizadas por DRX e MEV, e os resultados indicam que a pressÃ£o do gÃ¡s de trabalho pode ser usada como um parÃ¢metro se
Increasing Antibacterial Efficiency of Cu Surfaces by targeted Surface Functionalization via Ultrashort Pulsed Direct Laser Interference Patterning (2020)

Abstract Copper (Cu) exhibits great potential for application in the design of antimicrobial contact surfaces aiming to reduce pathogenic contamination in public areas as well as clinically critical environments. However, current application perspectives rely purely on the toxic effect of emitted Cu ions, without considering influences on the interaction of pathogenic microorganisms with the surface to enhance antimicrobial efficiency. In this study, it is investigated on how antibacterial properties of Cu surfaces against Escherichia coli can be increased by tailored functionalization of the substrate surface by means of ultrashort pulsed direct laser interference patterning (USP‐DLIP). Surface patterns in the scale range of single bacteria cells are fabricated to purposefully increase bacteria/surface contact area, while parallel modification of the surface chemistry allows to involve the aspect of surface wettability into bacterial attachment and the resulting antibacterial effectivity. The results exhibit a delicate interplay between bacterial adhesion and the expression of antibacterial properties, where a reduction of bacterial cell viability of up to 15‐fold can be achieved for E. coli on USP‐DLIP surfaces in comparison to smooth Cu surfaces. Thereby, it can be shown how the antimicrobial properties of copper surfaces can be additionally enhanced by targeted surface functionalization.
Hybrid, Gate-Tunable, van der Waals p–n Heterojunctions from Pentacene and MoS2 (2015)

The recent emergence of a wide variety of two-dimensional (2D) materials has created new opportunities for device concepts and applications. In particular, the availability of semiconducting transition metal dichalcogenides, in addition to semimetallic graphene and insulating boron nitride, has enabled the fabrication of "all 2D" van der Waals heterostructure devices. Furthermore, the concept of van der Waals heterostructures has the potential to be significantly broadened beyond layered solids. For example, molecular and polymeric organic solids, whose surface atoms possess saturated bonds, are also known to interact via van der Waals forces and thus offer an alternative for scalable integration with 2D materials. Here, we demonstrate the integration of an organic small molecule p-type semiconductor, pentacene, with a 2D n-type semiconductor, MoS2. The resulting p-n heterojunction is gate-tunable and shows asymmetric control over the antiambipolar transfer characteristic. In addition, the pentacene/MoS2 heterojunction exhibits a photovoltaic effect attributable to type II band alignment, which suggests that MoS2 can function as an acceptor in hybrid solar cells.
Patenting of Nanopharmaceuticals in Drug Delivery: No Small Issue (2007)

Nanotechnology is a rapidly evolving interdisciplinary field based on the manipulation of matter on a submicron scale, encompassing matter between 1 and 100 nanometers (nm). The currently registered nanotechnology patents comprise 35 countries being involved in the global distribution of these patents. Close to 3000 patents were issued in the USA since 1996 with the term 'nano' in the patents, with a considerable number having application in nanomedicine. The large majority of therapeutic patents are focused on drug delivery systems, highlighting an important application globally. Nanopharmaceutical patents are centered mainly on non-communicable diseases, with cancer receiving the greatest focus, followed by hepatitis. Drug delivery systems employing nanotechnology have the ability to allow superior drug absorption, controlled drug release and reduced side-effects, enhancing the effectiveness of existing drug delivery systems. Nanoparticle-based drug delivery systems may be among the first types of products to generate serious nanotechnology patent disputes as the multi-billion dollar pharmaceutical industry begins to adopt them. This review article aimed to locate patented nanopharmaceuticals in drug delivery online, employing pertinent key terms while searching the patent databases. Awarded and pending patents in the past 20 years pertaining to nanopharmaceutical or nano-enabled systems such as micelles, nanoemulsions, nanogels, liposomes, nanofibres, dendrimer technology and polymer therapeutics are presented in the review article, providing an overview of the diversity of the patent applications.
Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta (2017)

Preventive chemotherapy has long been practiced against nematode parasites of livestock, leading to widespread drug resistance, and is increasingly being adopted for eradication of human parasitic nematodes even though it is similarly likely to lead to drug resistance. Given that the genetic architecture of resistance is poorly understood for any nematode, we have analyzed multidrug resistant Teladorsagia circumcincta, a major parasite of sheep, as a model for analysis of resistance selection. We introgressed a field-derived multiresistant genotype into a partially inbred susceptible genetic background (through repeated backcrossing and drug selection) and performed genome-wide scans in the backcross progeny and drug-selected F2 populations to identify the major genes responsible for the multidrug resistance. We identified variation linking candidate resistance genes to each drug class. Putative mechanisms included target site polymorphism, changes in likely regulatory regions and copy number variation in efflux transporters. This work elucidates the genetic architecture of multiple anthelmintic resistance in a parasitic nematode for the first time and establishes a framework for future studies of anthelmintic resistance in nematode parasites of humans.
Tim‐1 regulates Th2 responses in an airway hypersensitivity model (2011)

T-cell immunoglobulin mucin-1 (Tim-1) is a transmembrane protein postulated to be a key regulator of Th2-type immune responses. This hypothesis is based in part upon genetic studies associating Tim-1 polymorphisms in mice with a bias toward airway hyperrespon-siveness (AHR) and the development of Th2-type CD4(+) T cells. Tim-1 expressed by Th2 CD4(+) T cells has been proposed to function as a co-stimulatory molecule. Tim-1 is also expressed by B cells, macrophages, and dendritic cells, but its role in responses by these cell types has not been firmly established. Here, we generated Tim-1-deficient mice to determine the role of Tim-1 in a murine model of allergic airway disease that depends on the development and function of Th2 effector cells and results in the generation of AHR. We found antigen-driven recruitment of inflammatory cells into airways is increased in Tim-1-deficient mice relative to WT mice. In addition, we observed increased antigen-specific cytokine production by splenocytes from antigen-sensitized Tim-1-deficient mice relative to those from controls. These data support the conclusion that Tim-1 functions in pathways that suppress recruitment of inflammatory cells into the airways and the generation or activity of CD4(+) T cells.
Thermomechanical Analysis on Stress Mitigation of FCPBGA with Low Melting Temperature Solder and Low Elastic Modulus Cu Pillar (2022)

Increasing thermomechanical stress in complex and large flip-chip packages is a critical issue in maintaining mechanical integrity and reliability of the packages. Effects of varying mechanical properties of joining materials and organic substrate on stress mitigation in low-k dielectric layer under Cu pillar bump were studied using thermomechanical analysis. Lowering coefficient of thermal expansion (CTE) of organic substrate and lowering melting temperature of solder contribute to significant stress reduction. The effect of Cu pillar’s elastic modulus becomes relevant when its value is greatly reduced.
Electrooptical Effects in the Polymer Dispersed Nematic Liquid Crystals: Response Times (1990)

Abstract The response times for two types of polymer dispersed liquid crystals (PDLC) with normally and tangentially anchored drops are studied experimentally. It is shown that the normal anchoring provides the shorter turn-on and turn-off times.
Stable Cu Catalysts Supported by Two‐dimensional SiO2 with Strong Metal–Support Interaction (2022)

Cu-based catalysts exhibit excellent performance in hydrogenation reactions. However, the poor stability of Cu catalysts under high temperatures has restricted their practical applications. The preparation of stable Cu catalysts supported by SiO<sub>2</sub> with strong metal-support interaction (SMSI) has thus aroused great interest due to the high abundance, low toxicity, feasible processability, and low cost of SiO<sub>2</sub> . The challenge in the construction of such SMSI remains to be the inertness of SiO<sub>2</sub> . Herein, a simple and scalable method is developed to prepare 2D silica (2DSiO<sub>2</sub> ) supported Cu catalysts with SMSI by carefully manipulating the topological exfoliation of CaSi<sub>2</sub> with CuCl<sub>2</sub> and thereafter calcination. The prepared Cu-2DSiO<sub>2</sub> catalysts with the unique encapsulated Cu nanoparticles exhibit excellent activity and long-term stability in high-temperature CO<sub>2</sub> hydrogenation reactions. This feasible and low-cost solution for stabilizing Cu catalysts might shed light on their realistic applications.
Online Detection of Tonal Pop-Out in Modulating Contexts (2003)

We investigated the spontaneous detection of "wrong notes" in a melody that modulated continuously through all 24 major and minor keys. Three variations of the melody were composed, each of which had distributed within it 96 test tones of the same pitch, for example, A2. Thus, the test tones would blend into some keys and pop out in others. Participants were not asked to detect or judge specific test tones; rather, they were asked to make a response whenever they heard a note that they thought sounded wrong or out of place. This task enabled us to obtain subjective measures of key membership in a listening situation that approximated a natural musical context. The frequency of observed "wrong-note" responses across keys matched previous tonal hierarchy results obtained using judgments about discrete probes following short contexts. When the test tones were nondiatonic notes in the present context they elicited a response, whereas when the test tones occupied a prominent position in the tonal hierarchy they were not detected. Our findings could also be explained by the relative salience of the test pitch chroma in short-term memory, such that when the test tone belonged to a locally improbable pitch chroma it was more likely to elicit a response. Regardless of whether the local musical context is shaped primarily by "bottom-up" or "topdown" influences, our findings establish a method for estimating the relative salience of individual test events in a continuous melody.
G-107 Enzymatic manipulation of antibody Fc-mediated effector functions (2016)

In order to evade host immune mechanisms, many bacteria secrete immunomodulatory enzymes. Streptococcus pyogenes, one of the most common human pathogens, secretes a large endoglycosidase, EndoS, which removes carbohydrates in a highly specific manner from IgG antibodies. This renders antibodies incapable of eliciting[LINE SEPARATOR]host effector functions through either complement or Fc g receptors, providing the bacteria with a survival advantage. On account of this antibody-specific modifying activity, EndoS is currently being developed as a promising injectable therapeutic for autoimmune diseases that rely on autoantibodies. Additionally, EndoS is a key enzyme used in the chemoenzymatic synthesis of homogenously glycosylated antibodies with tailored Fc g receptor-mediated effector functions. Despite the tremendous utility of this enzyme, the molecular basis of EndoS specificity for, and processing of, IgG antibodies has remained poorly understood. We have recently determined the X-ray crystal structure of EndoS. Based on this structure, we rationally designed chimeric endoglycosidases in which we exchanged the glycosidase domain of EndoS with that of EndoF1 in order to create unique enzymes for customized glycan remodeling on IgG antibodies. This novel glycoprotein engineering strategy for constructing chimeric endoglycosidases that are able to manipulate the glycan composition on IgG antibodies provides new opportunities to engineer antibodies with unique glycan compositions for therapeutic applications.
Revista de Investigación Clínica–Clinical and Translational Investigation–: Editors’ Choices 6 Years Later (2021)

In this article, a series of original manuscripts and reviews published between 2015 and 2021 in the Revista de Investigación Clínica -Clinical and Translational Investigation- chosen by the Editors are presented. The articles were selected according to what the editors considered are the most outstanding contributions based on originality, and the potential impact of the information provided on translational medicine, rather than on the number of readings and citations.
Low-power, small-footprint gigabit Ethernet-compatibleoptical receiver circuit in 0.25 µm CMOS (2000)

Experimental results for a gigabit Ethernet-compatible photo-receiver circuit generating CMOS logic level are presented. A single-ended preamplifier is combined with a multi-stage differential postamplifier with inverse scaling to increase bandwidth. Circuits are realised in 0.25 µm CMOS, dissipating 26 mW or less. The analogue portion of the receiver operates at 2 µA average input current at 1.25 Gbit/s, increasing to ~10 µm when CMOS levels are generated. A maximum speed of 2.1 Gbit/s is reported for the analogue portion.
Panel 6: Vaccines (2013)

Acute otitis media continues to be a burden on children and families, especially those who suffer from frequent recurrences. The 7-valent PCV (PCV7) has reduced the burden of disease as well as shifted the pneumococcal serotypes and the distribution of otopathogens currently reported in children with AOM. Antibiotic resistance remains an ongoing challenge. Multiple candidate antigens have demonstrated the necessary requirements of conservation, surface exposure, immunogenicity, and protection in animal models. Further research on the role of each antigen in pathogenesis, in the development of correlates of protection in animal models, and in new adjuvants to elicit responses in the youngest infants is likely to be productive and permit more antigens to move into human clinical trials.
Synthesis, Structure, and Reactivity of Neutral η3-Propargylpalladium Complexes (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSynthesis, Structure, and Reactivity of Neutral η3-Propargylpalladium ComplexesKen Tsutsumi, Sensuke Ogoshi, Shinji Nishiguchi, and Hideo KurosawaView Author Information Department of Applied Chemistry Faculty of Engineering, Osaka University Suita, Osaka 565, Japan Cite this: J. Am. Chem. Soc. 1998, 120, 8, 1938–1939Publication Date (Web):February 14, 1998Publication History Received29 September 1997Published online14 February 1998Published inissue 1 March 1998https://pubs.acs.org/doi/10.1021/ja973383ihttps://doi.org/10.1021/ja973383irapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views1012Altmetric-Citations110LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Ligands,Molecular structure,Monomers,Palladium,Reactivity Get e-Alerts
Effect of modulation p-doping on the differential carrier lifetime of quantum dot lasers (2012)

We report on spectrally resolved differential carrier lifetime measurements of un-doped and modulation p-doped 1300nm quantum dot laser. We find that the differential carrier lifetime is significantly reduced for p-doped samples compared to essentially identical un-doped samples in line with enhanced Auger recombination. With increasing temperature the results from the un-doped sample are unchanged, whilst an increase in differential carrier lifetime is observed for the pdoped sample. This is in agreement with the Auger rate reducing with increasing temperature. The effect of modulation p-doping on inter-level scattering times and the recombination rate of the excited state are discussed.
Computational Modeling of Lithium Ion Conduction in Li-Fe-O Systems (2011)

Abstract not Available.
Cryoprotectants & cryopreservation of equine semen: a review of industry cryoprotectants and the effects of cryopreservation on equine semen membranes (2016)

Equine semen is a one of the most difficult in the industry to cryopreserve efficiently without causing damage to the membrane or apoptosis. This review consists of an in depth analysis of current cryoprotectant classes, membrane damage issues, reactive oxygen species generation, and apoptosis- all of which are exacerbated by cryopreservation.