gebhart/patrepeval huggingface dataset:
Neuroendocrinology in Physiology and Medicine (2000)

OOK REVIEWSAs the first chapter of this book states,‘neuroendocrinology deals with all the inter-actions between hormones and nerve struc-tures’. In spite of its ambiguity, this definitionreflects the essence of the discipline ratherwell. Thus, at cellular and molecular levels ofanalysis, neuroendocrinology tries to de-scribe the signalling mechanisms and themolecules involved in hormonal modulationof neuronal activity. At organismal and sys-temic levels, it refers directly to the conceptof homeostasis as the very essence of inte-grative biology. On the one hand, the braincan control the release of hormones into thecirculation, thereby linking environmental,behavioural and experience-dependentchanges with body function. On the otherhand, hormones secreted from the periph-eral endocrine glands can exert powerfulfeedback effects on brain architecture andMitochondria are probably the guilty partyor at least ‘accomplices’ in the cell deaththat characterizes neurodegenerative dis-orders. Among the evidence supporting thisview, experimental block of the respiratorychain by selective mitochondrial toxins inlaboratory animals leads to neurological andhistological abnormalities that can be veryreminiscent of the human diseases. The in-volvement of mitochondria was reinforcedby the recent burst of research of excep-tional quality on the role of this organellein apoptosis. Except for one remarkablemonograph
Transpose domain filtering: Dual algorithms in adaptive filtering (2008)

In this paper, we describe a new parameter estimation methodology called transpose domain filtering (TDF). TDF is a processing formulation that that is different from conventional processing (e.g., beamscan processing) in that the weight vector is applied in the domain that lies transpose to the signal model. For a typical radar array processing problem, this means TDF would apply the weight vector in the snapshot domain as opposed to the element domain. We provide two examples of TDF applied to minimum variance distortionless response (MVDR) beam scan and code division multiple access (CDMA) synchronization. We later show that rank reduction techniques can be used in TDF, and then prove that when principal components rank reduction is applied to TDF, the result is mathematically equivalent to the better-known multiple signal characterization (MUSIC) algorithm.
Inverse Identification at Very High Strain Rate of the Johnson–Cook Constitutive Model on the Ti‐6Al‐4 V Alloy With a Specially Designed Direct‐impact Kolsky Bar Device (2014)

ABSTRACT In the present work, an inverse identification of the Johnson–Cook constitutive model is performed on the titanium alloy Ti‐6Al‐4 V at three strain rates until about 2·10 4 s −1 (till about 1.1·10 4 s −1 of plastic strain rate) on a specially designed direct impact Kolsky bar device. First, the design of such a device must meet several criteria, and is shown to be the solution of an optimization problem. A systematic design procedure for such a device is then introduced. Second, an inverse analysis using the finite element code ABAQUS is carried out to identify the Johnson–Cook parameters on experimental data obtained with the designed system.
Stimulated Raman self-scattering of laser pulses (1989)

A theoretical investigation is reported of stimulated Raman self-scattering (self-STRS) of laser pulses. It is shown that the simultaneous effects of phase self-modulation and of the dispersion in the spectral range of negative dispersion of the group velocities enhance the efficiency of self-STRS, whereas in the positive dispersion range these effects suppress self-STRS. The observed STRS spectra of fiber waveguides are studied.
Paper 128: Comparison of Engineered BMP Peptide‐Coated and Non‐Coated Bioresorbable Interference Screws on Tendon‐Bone Healing in an Ovine Model (2012)

Tendon grafts plus bioresorbable interference screws transplanted into bone tunnels have been widely used for anterior cruciate ligament (ACL) reconstruction. However, interference screw fixation has the potential to negatively influence tendon bone healing. The purpose of this study was to determine whether a bioresorbable interference screw coated with an engineered peptide derivative of bone morphogenetic protein-2 (eBMP2) improved tendon-bone healing compared to the screw without sub-BMP coating.
Halato-telechelic polymers. 1. Gel formation and its dependence on the ionic content (1981)

peer reviewed
Association testing by DNA pooling: An effective initial screen (2002)

With an ever-increasing resource of validated single-nucleotide polymorphisms (SNPs), the limiting factors in genome-wide association analysis have become genotyping capacity and the availability of DNA. We provide a proof of concept of the use of pooled DNA as a means of efficiently screening SNPs and prioritizing them for further study. This approach reduces the final number of SNPs that undergo full, sample-by-sample genotyping as well as the quantity of DNA used overall. We have examined 15 SNPs in the cholesteryl ester transfer protein (CETP) gene, a gene previously demonstrated to be associated with serum high-density lipoprotein cholesterol levels. The SNPs were amplified in two pools of DNA derived from groups of individuals with extremely high and extremely low serum high-density lipoprotein cholesterol levels, respectively. P values <0.05 were obtained for 14 SNPs, supporting the described association. Genotyping of the individual samples showed that the average margin of error in frequency estimate was approximately 4% when pools were used. These findings clearly demonstrate the potential of pooling techniques and their associated technologies as an initial screen in the search for genetic associations.
Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei (2012)

A number of hydroxamic acid derivatives which inhibit human histone deacetylases were investigated for efficacy against cultured bloodstream form Trypanosoma brucei. Three out of the four classes tested displayed significant activity. The majority of compounds blocked parasite growth in the submicromolar range. The most potent was a member of the sulphonepiperazine series with an IC(50) of 34nM. These results identify lead compounds with potential for the development of a novel class of trypanocidal agent.
Precision metrology through wavelength-demultiplexed laser interferometry (Conference Presentation) (2019)

Most light enabled sensing and imaging techniques have depth resolutions that are larger than a few micrometers. An exception to this is the single wavelength laser coherent interferometry, known for its sensitivity and resolution lambda/1000. However, due to 2pi periodicity of the cosine function, the unambiguous range of single wavelength interferometry systems is limited to lambda/2. Researchers in the past have performed interferometry with multiple wavelengths and detected phase on a single photodetector. The beat signal of the multiple wavelengths has been used to extend the range, but this technique worsens the resolution by the same factor. To alleviate this range-resolution tradeoff, our system uses multiple wavelengths for the interference, but wavelength demultiplexes the interferograms before detecting them on separate photodetectors. The resolution is preserved to that of a single wavelength interferometer, while the range is extended to the lowest common multiple of the multiple wavelengths. In our experiment, we use two wavelengths, 1525 nm and 1550 nm, and employ techniques of simultaneous phase interferometry to extract and unwrap the phase. We are able to measure discrete positions of a piezo electric stage up to an unambiguous distance of 94.55µm, with nanometer precision. Furthermore, by incorporating 4F lens systems with our technique, we demonstrate the capabilities of measuring samples with high precision. Our system is instantaneous, computationally cheap, utilizes inexpensive components, and has the highest dynamic range of 1e5.
Mechanism and function of poleward flux in Xenopus extract meiotic spindles (2005)

In Xenopus extract meiotic spindles, microtubules slide continuously towards their minus ends, a process called poleward flux. This article discusses recent progress in determining the mechanism of poleward flux, and its functions in spindle organization and generating force on chromosomes. Bipolar organization is required for flux and inhibition of the mitotic kinesin Eg5 inhibits flux, suggesting the sliding force for flux is generated by Eg5 pushing anti-parallel microtubules apart. An important function of flux in spindle organization may be to transport minus ends nucleated at chromatin towards the pole. By pulling microtubules through attachment sites at kinetochores, flux may generate poleward force on metaphase chromosomes.
Low-cost antenna-in-package solutions for 60-GHz phased-array systems (2010)

A low-cost, fully-integrated antenna-in-package solution for 60-GHz phased-array system is demonstrated. Sixteen patch antennas are integrated into a 28 mm × 28 mm ball grid array together with a flip-chip attached phased-array transmitter or receiver chip. The packages have first been fabricated using low temperature co-fired ceramic technology, and then built using conventional printed circuit board processes for lower manufacturing cost. Antenna chamber measurement has shown ~5 dBi unit antenna gain across the 60-GHz frequency band covering all four IEEE 802.15.3c channels. The packaged transmitter and receiver chipsets, each mounted on an evaluation board, have demonstrated beam-steered, non-line-of-sight links with data rates up to 5.3 Gb/s.
Phosphor-converted high power LEDs (2007)

Phosphor converted Light Emitting Diodes (pcLED) have undergone many changes of design over the last 11 years. For advanced applications, however, besides other binning criteria a closely binned color point appears to be a major issue. Manufacturing yield is closely related to this point. Philips Lumileds Lighting (PLL) introduced very recently a new compact solid state color converter - Lumiramic - which allows much closer color control by selecting perfect matches between blue pump LEDs and previously characterized converter tiles in a pick-and-place process. Lumiramic phosphor technology utilizes a ceramic phosphor plate and PLL's new Thin Film Flip Chip (TFFC) technology. A first application in Automotive Forward Lighting and some of the design considerations are outlined in the paper
Distribution of Potentially Bioavailable Natural Organic Carbon in Aquifer Sediments at a Chloroethene-Contaminated Site (2012)

The distribution of natural organic carbon was investigated at a chloroethene-contaminated site where complete reductive dechlorination of tetrachloroethene (PCE) to vinyl chloride and ethene was observed. In this study, operationally defined potentially bioavailable organic carbon (PBOC) was measured in surficial aquifer sediment samples collected at varying depths and locations in the vicinity of a dense nonaqueous phase liquid (DNAPL) source and aqueous phase plume. The relationship between chloroethene concentrations and PBOC levels was examined by comparing differences in extractable organic carbon in aquifer sediments with minimal chloroethene exposure relative to samples collected in the source zone. Using performance-monitoring data, direct correlations with PBOC were also developed with chloroethene concentrations in groundwater. Results show a logarithm-normal distribution for PBOC in aquifer sediments with a mean concentration of 187 mg/kg. PBOC levels in sediments obtained from the underlying confining unit were generally greater when compared to sediments collected in the sandy surficial aquifer. Results demonstrated a statistically significant inverse correlation (p=0.007) between PBOC levels in aquifer sediments and chloroethene concentrations for selected monitoring wells in which chloroethene exposure was the highest. Results from laboratory exposure assays also demonstrated that sediment samples exhibited a reduction in PBOC levels of 35% and 73%, respectively, after a 72-h exposure period to PCE (20,000 μg/L). These results support the notion that PBOC depletion in sediments may be expected in chloroethene-contaminated aquifers, which has potential implications for the long-term sustainability of monitored natural attenuation.
Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase (2017)

Monoacylglycerol lipase (MAGL) is the main enzyme responsible for degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the CNS. MAGL catalyzes the conversion of 2-AG to arachidonic acid (AA), a precursor to the proinflammatory eicosannoids such as prostaglandins. Herein we describe highly efficient MAGL inhibitors, identified through a parallel medicinal chemistry approach that highlighted the improved efficiency of azetidine and piperidine-derived carbamates. The discovery and optimization of 3-substituted azetidine carbamate irreversible inhibitors of MAGL were aided by the generation of inhibitor-bound MAGL crystal structures. Compound 6, a highly efficient and selective MAGL inhibitor against recombinant enzyme and in a cellular context, was tested in vivo and shown to elevate central 2-AG levels at a 10 mg/kg dose.
Risk of Coronary Artery Disease Associated With Polymorphism of the Cytochrome P450 Epoxygenase CYP2J2 (2004)

A functionally relevant polymorphism of the CYP2J2 gene is independently associated with an increased risk of coronary artery disease.
Novel cage clusters of MoS2 in the gas phase. (2005)

Laser evaporation of MoS(2) nanoflakes gives negatively charged magic number clusters of compositions Mo(13)S(25) and Mo(13)S(28), which are shown to have closed-cage structures. The clusters are stable and do not show fragmentation in the post-source decay analysis even at the highest laser powers. Computations suggest that Mo(13)S(25) has a central cavity with a diameter of 4.5 A. The nanosheets of MoS(2) could curl upon laser irradiation, explaining the cluster formation.
Supplemental Figure S2. Concordance index of the PAM50 and GGI signatures in combination with the MV score in four datasets from An Endothelial Gene Signature Score Predicts Poor Outcome in Patients with Endocrine-Treated, Low Genomic Grade Breast Tumors (2023)

&lt;p&gt;The concordance index of the PAM50 and GGI signatures alone or in combination with the MV score in four independent datasets&lt;/p&gt;
Direct In Vitro Comparison of the Anti-Leishmanial Activity of Different Olive Oil Total Polyphenolic Fractions and Assessment of Their Combined Effects with Miltefosine (2022)

The bioactive compounds present in the edible products of the olive tree have been extensively studied and their favorable effects on various disease risk factors have been demonstrated. The aim of this study was to perform a comparative analysis of the anti-leishmanial effects of total phenolic fractions (TPFs) derived from extra virgin olive oil with different phenolic contents and diverse quantitative patterns. Moreover, the present study investigated their association with miltefosine, a standard anti-leishmanial drug, against both extracellular promastigotes and intracellular amastigotes of a viscerotropic and a dermotropic <i>Leishmania</i> strain. The chemical compositions of TPFs were determined by high performance liquid chromatography with diode array detection (HPLC-DAD). Analysis of parasite growth kinetics, reactive oxygen species production and apoptotic events were determined by microscopy and flow cytometry. Our results revealed that the presence of oleacein (OLEA) and oleocanthal (OLEO) secoiridoids enhances the anti-leishmanial effect of TPF. The association between TPFs and miltefosine was suggested as being additive in <i>Leishmania infantum</i> and <i>Leishmania major</i> promastigotes, and as antagonistic in intracellular amastigotes, as was evaluated with the modified isobologram method. The obtained data verified that TPFs are bioactive dietary extracts with a strong anti-leishmanial activity and highlighted that fractions that are richer in OLEA and OLEO phenolic compounds possess stronger inhibitory effects against parasites. This study may contribute to improving the therapeutic approaches against leishmaniasis.
Plant Hormonomics: Multiple Phytohormone Profiling by Targeted Metabolomics (2018)

Phytohormones are physiologically important small molecules that play essential roles in intricate signaling networks that regulate diverse processes in plants. We present a method for the simultaneous targeted profiling of 101 phytohormone-related analytes from minute amounts of fresh plant material (less than 20 mg). Rapid and nonselective extraction, fast one-step sample purification, and extremely sensitive ultra-high-performance liquid chromatography-tandem mass spectrometry enable concurrent quantification of the main phytohormone classes: cytokinins, auxins, brassinosteroids, gibberellins, jasmonates, salicylates, and abscisates. We validated this hormonomic approach in salt-stressed and control Arabidopsis (<i>Arabidopsis thaliana</i>) seedlings, quantifying a total of 43 endogenous compounds in both root and shoot samples. Subsequent multivariate statistical data processing and cross-validation with transcriptomic data highlighted the main hormone metabolites involved in plant adaptation to salt stress.
Investigation of the reliability of Cu and Co UBM layers in thermal-cycling tests (2004)

Despite the approaching ban on Pb in electronics, possibilities for replacing small pitch SnPb bumps are still limited. Electroplating, which is the most important process for small pitch bumping, complicates the alloy formation. In this paper, pure Sn bumps are investigated on their reliability behavior during thermal-cycling tests. Both electroplated Cu and Co are tested as UBM material. A Cu-SnPb sample is used as reference. The system lifetime of this reference sample could not be achieved with pure Sn. However, it is believed that by modifying some process conditions, the CoSn lifetime could be improved.
Intracellular stress tomography reveals stress focusing and structural anisotropy in cytoskeleton of living cells (2003)

We describe a novel synchronous detection approach to map the transmission of mechanical stresses within the cytoplasm of an adherent cell. Using fluorescent protein-labeled mitochondria or cytoskeletal components as fiducial markers, we measured displacements and computed stresses in the cytoskeleton of a living cell plated on extracellular matrix molecules that arise in response to a small, external localized oscillatory load applied to transmembrane receptors on the apical cell surface. Induced synchronous displacements, stresses, and phase lags were found to be concentrated at sites quite remote from the localized load and were modulated by the preexisting tensile stress (prestress) in the cytoskeleton. Stresses applied at the apical surface also resulted in displacements of focal adhesion sites at the cell base. Cytoskeletal anisotropy was revealed by differential phase lags in X vs. Y directions. Displacements and stresses in the cytoskeleton of a cell plated on poly-L-lysine decayed quickly and were not concentrated at remote sites. These data indicate that mechanical forces are transferred across discrete cytoskeletal elements over long distances through the cytoplasm in the living adherent cell.
The Mitochondrial Cardiolipin Remodeling Enzyme Lysocardiolipin Acyltransferase is a Novel Target in Pulmonary Fibrosis (2014)

This study is the first to identify modulation of LYCAT expression in fibrotic lungs and offers a novel therapeutic approach for ameliorating lung inflammation and pulmonary fibrosis.
Lumbar Microendoscopic Discectomy (2005)

Low-back pain is one of the most common complaints that lead patients to seek medical attention. It is estimated that there are nearly 15 million physician office visits each year for low-back pain (1). Additionally, back pain causes nearly 80% of workers to miss at least 8 wk of work following a back injury (2). Estimates of lifetime prevalence and annual incidence has been reported to be 60–90 and 5%, respectively (3). With this prevalence, it has been estimated that the total health care expenditures incurred by individuals with back pain in the United States reached $90.7 billion. The total incremental expenditures attributable to back pain among these individuals are estimated to be approx $23.6 billion. On average, individuals with back pain encumbered health care expenditures about 60% higher than individuals without back pain (4).
Dawei sea port development in Myanmar (2013)

Aurecon in joint venture with Halcrow was retained by Dawei Development Company to assist with the Master Planning and detailed design of the proposed Dawei Port in Myanmar. Through an extensive trade projection study a range of local, national and international cargo origins were identified and potential volumes estimated. This was driving the port configuration as this has to match the cargo type and mode of movement of the cargo. Having gathered all the relevant site data an optimised port configuration was developed which offered significant benefits to the client including reduced capital cost and improved operations. The proposed development will potentially include 8 container berths, 8 dry bulk and 8 liquid bulk berths as well as 27 general cargo berths stretching across some 13,000 m. To accommodate some of the anchor tenants the port will need to be able to cater for large bulk carriers which require significant dredging and reclamation. Working closely with the client a suitable level of flexibility was built into the terminal quay design to optimise flexibility and minimise disruptions in future stages of development.
Demonstration of SiC Pressure Sensors at 750 °C (2014)

We report the first demonstration of MEMS-based 4H-SiC piezoresistive pressure sensors tested at 750 °C and in the process confirmed the existence of strain sensitivity recovery with increasing temperature above 400 °C, eventually achieving near or up to 100 % of the room temperature values at 750 °C. This strain sensitivity recovery phenomenon in 4H-SiC is uncharacteristic of the well-known monotonic decrease in strain sensitivity with increasing temperature in silicon piezoresistors. For the three sensors tested, the room temperature full-scale output (FSO) at 200 psig ranged between 29 and 36 mV. Although the FSO at 400 °C dropped by about 60 %, full recovery was achieved at 750 °C. This result will allow the operation of SiC pressure sensors at higher temperatures, thereby permitting deeper insertion into the engine combustion chamber to improve the accurate quantification of combustor dynamics.
Release of prostaglandin I2 from hog kidney by propranolol. (1982)

Prostaglandin I2 (PGI2) decreases blood pressure. Perfusion of isolated hog kidney by propranolol in modified Krebs-Ringer solution resulted in a significant increase in 6-keto-prostaglandin F1 alpha, the major metabolite of PGI2. Prostaglandin E2 and renin activity remained unchanged. Because the concentration of PGI2-like substance in the renal vein has been shown to be greater than in the renal artery after bradykinin infusion, a contribution of PGI2 to the regulation of blood pressure was proposed. Isoproterenol has been shown to augment urinary kallikrein, but the effect of urinary kallikrein on propranolol is unclear. With a modified Krebs-Ringer solution free of plasma kininogen, a renin substrate, it was concluded that propranolol (1) induces PGI2 release from the kidney, which may contribute to a direct antihypertensive action of this beta-adrenergic blocking agent, and (2) decreases urinary kallikrein.