gebhart/patrepeval huggingface dataset:
Proposal and Experimental Verification of Design Guidelines for Centrifugal Compressor Impellers With Curvilinear Element Blades to Improve Compressor Performance (2014)

This study numerically and experimentally examines the effects of applying curvilinear element blades to fully shrouded centrifugal impellers on the performance of the centrifugal compressor stages. The curvilinear element blades we developed for centrifugal turbomachinery were defined by the coordinate transformations between a revolutionary flow-coordinate system and a cylindrical coordinate system. All the blade sections in the transferred cylindrical coordinate system were moved and stacked spanwise in accordance with the given “lean profile,” which meant the spanwise distribution profile of movement of the blade sections, to form a new leaned blade surface. The effects of the curvilinear element blades on the impeller flowfield were investigated using numerical simulations, and the optimum design guidelines for impellers with curvilinear element blades were considered. Then, a new impeller using these design guidelines was designed and the performance improvement of a new compressor stage was evaluated by numerical simulations. As mentioned in several papers, we numerically confirmed that curvilinear element blades with a negative tangential lean (TGL) profile improved the velocity distribution and stage efficiency because they help to suppress the secondary flows in the impeller. The negative TGL mentioned in this paper represents the lean profile in which the blade hub end leans forward in the direction of the impeller rotation compared to the blade shroud end. At the same time, we also found that the stall margin of these impellers deteriorated due to the increase in relative velocity deceleration near the suction surface of the shroud in the forward part of the impeller. Therefore, we propose new design guidelines for impellers with the curvilinear element blades by applying a negative TGL to line element blades in which the blade loading of the shroud side in the forward part of the impeller is reduced. We confirmed from the numerical simulation results that the performance of the new compressor stage improved compared to that in the corresponding conventional one. The new design guidelines for the curvilinear element blades were experimentally verified by comparing the performance of the new compressor stage with the corresponding conventional one. The measured efficiency of the new compressor stage was 2.4% higher than that of the conventional stage with the stall margin kept comparable. A comparison of the measured velocity distributions at the impeller exit showed that the velocity distribution of the new impeller was much more uniform than that of the conventional one.
Distributed data collection: archiving, indexing, and analysis (2008)

As computing hardware becomes more powerful and systems become bigger, the amount of data we can collect within a system grows seemingly without bounds. These systems share a common characteristic: the volume of raw data available is far higher than can be handled by the application or user. The key problem is thus to identify some small amount of data which is of interest, obtaining it and presenting it to the user. 
In this thesis we examine distributed data collection environments, and advocate data-aware and storage-centric approaches. Collected raw data is stored within the network, and only the most relevant information is presented to the application. We apply two strategies: (i) archiving, indexing and querying to retrieve discrete portions of data, and (ii) mathematical modeling to extract relationships spread more diffusely across the data. We propose mechanisms for archiving, indexing, and analysis, and describe them in the context of systems incorporating them. 
First we address storage and indexing of high-speed event data in a resource-rich environment. A disk-based storage system operates on commodity hardware, yet guarantees writing at high rates to avoid loss. A signature file-based index allows indexing of high-speed data in real time, for efficient ad hoc querying. A network monitoring system based on these mechanisms is presented and evaluated. 
Next we leverage the resources of a few resource-rich systems within a resource-constrained environment to index and route queries to remote sensors. These sensors send summaries of stored data to more capable proxy nodes, which use a novel search structure, the Interval Skip Graph, representing multiple records by a single imprecise key. We present a prototype implementation of a sensor network storage system based on these mechanisms. 
Lastly we address analysis and model-building from feature-rich but poorly structured events. In our approach, statistical machine learning techniques are used to build models of application and system behavior in a data center, relying on an automated feature identification mechanism to identify model inputs from within the raw data stream. We present and evaluate Modellus , a data center monitoring and analysis system based on these mechanisms.
Hemmung der Aktivierung LPS- und IL-6-vermittelter, pro-fibrogener Signalwege in hepatischen Sternzellen durch Ursodeoxycholyl Lysophosphatidylethanolamid (UDCA-LPE) (2013)

Einleitung: Die Entzündungsreaktion in der Leber mit Aktivierung inflammatorischer Zellen und Freisetzung von Entzündungsmediatoren spielt bei der Stimulation hepatischer Sternzellen zur Produktion extrazellulärer Matrix eine wichtige Rolle. UDCA-LPE ist ein Gallensäure-Phospholipid-Konjugat mit anti-inflammatorischer Wirkung in vitro und in vivo. In der vorliegenden Arbeit soll der Einfluss der Suppression inflammatorischer Mediatoren und Signalwege durch UDCA-LPE auf die fibrogene Aktivierung hepatischer Sternzellen untersucht werden.
Impact of parent education groups on family environment (1983)

Abstract This study assesses the nature of change over time in the family environment of parents attending Adlerian parent education groups and determines whether these groups foster democratic parental attitudes and behavior toward children.
Protein/ Hormone Based Nanoparticles as Carriers for Drugs Targeting Protein-Protein Interactions (2019)

Protein based nanoparticles, due to their advantages, can be suitable carriers for drugs targeting PPIs. This can open a new opportunity in the emerging field of multifunctional therapeutics.
Benzene Adsorption on Nanoporous Silica Gels with Grafted Polyfluoroalkyl Layers and the Wettability (2021)

Features of the benzene adsorption in polyfluoroalkyl layers of different structures grafted on surfaces of silica gel (SG) are studied using gas chromatography, static adsorption, and diffuse reflectance IR spectroscopy. After modification, Henry’s law constants determined from the gas chromatography data and the static benzene adsorption values fall in the order SG > SG–F(III) > SG–F > SG–iso-F(III), where samples SG–F(III), SG–F, and SG–iso-F(III) are produced using silanes n‑C6F13(CH2)2SiCl3, n‑C6F13(CH2)2Si(CH3)2Cl, and iso-C3F7(CH2)2SiCl3, respectively. It is found that the energy characteristics of adsorption of benzene and other hydrocarbons on the SG–F(III) sample with the linear trifunctional modifier are 3–7 kJ/mol higher than the respective characteristics determined on the initial support. The contact angles for nanoporous silica gels with polyfluoroalkyl layers are calculated from desorption data in the region of the capillary condensation hysteresis of the benzene adsorption isotherms.
Near-infrared photoimmunotherapy: design and potential applications for cancer treatment and beyond (2022)

Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed cancer treatment modality based on a target-specific photosensitizer conjugate (TSPC) composed of an NIR phthalocyanine photosensitizer and an antigen-specific recognition system. NIR-PIT has predominantly been used for targeted therapy of tumors via local irradiation with NIR light, following binding of TSPC to antigen-expressing cells. Physical stress-induced membrane damage is thought to be a major mechanism underlying NIR-PIT-triggered photokilling. Notably, NIR-PIT can rapidly induce immunogenic cell death and activate the adaptive immune response, thereby enabling its combination with immune checkpoint inhibitors. Furthermore, NIR-PIT-triggered "super-enhanced permeability and retention" effects can enhance drug delivery into tumors. Supported by its potential efficacy and safety, NIR-PIT is a rapidly developing therapeutic option for various cancers. Hence, this review seeks to provide an update on the (i) broad range of target molecules suitable for NIR-PIT, (ii) various types of receptor-selective ligands for designing the TSPC "magic bullet," (iii) NIR light parameters, and (iv) strategies for enhancing the efficacy of NIR-PIT. Moreover, we review the potential application of NIR-PIT, including the specific design and efficacy in 19 different cancer types, and its clinical studies. Finally, we summarize possible NIR-PIT applications in noncancerous conditions, including infection, pain, itching, metabolic disease, autoimmune disease, and tissue engineering.
Fabrication of field-effect transistor device with higher fullerene, C88 (2005)

A fullerene field-effect transistor (FET) device has been fabricated with thin films of C88, and n-channel normally on depletion-type FET properties have been found in this FET device. The C88 FET exhibited a high mobility, μ, of 2.5×10−3cm2V−1s−1 at 300 K, in fullerene FETs. The carrier transport showed a thermally activated hopping transport. The n-channel normally on FET properties and the hopping transport reflect the small mobility gap and low carrier concentration in the channel region of C88 thin films.
Identification of secreted bacterial proteins by noncanonical amino acid tagging (2013)

Pathogenic microbes have evolved complex secretion systems to deliver virulence factors into host cells. Identification of these factors is critical for understanding the infection process. We report a powerful and versatile approach to the selective labeling and identification of secreted pathogen proteins. Selective labeling of microbial proteins is accomplished via translational incorporation of azidonorleucine (Anl), a methionine surrogate that requires a mutant form of the methionyl-tRNA synthetase for activation. Secreted pathogen proteins containing Anl can be tagged by azide-alkyne cycloaddition and enriched by affinity purification. Application of the method to analysis of the type III secretion system of the human pathogen Yersinia enterocolitica enabled efficient identification of secreted proteins, identification of distinct secretion profiles for intracellular and extracellular bacteria, and determination of the order of substrate injection into host cells. This approach should be widely useful for the identification of virulence factors in microbial pathogens and the development of potential new targets for antimicrobial therapy.
Strain-compensated AlAs-InGaAs quantum-cascade lasers with emission wavelength 3-5 μm (2008)

A design strategy for short wavelength (equation) quantum-cascade lasers (QCLs) on InP substrates is discussed and the performance of these lasers evaluated. The QCLs are based on strain-compensated AlAs-In<sub>0.73</sub>Ga<sub>0.27</sub>As heterostructures grown using gas-source molecular-beam epitaxy on InP substrates. Both composite barriers based on AlAs-In<sub>0.55</sub>Al<sub>0.45</sub>As and composite wells based on In<sub>0.73</sub>Ga<sub>0.27</sub>As-In<sub>0.55</sub>Al<sub>0.45</sub>As are used to achieve laser emission at wavelengths as short as 3.05 &mu;m by avoiding leakage from the upper laser state into either the higher-lying miniband or into indirect states within the heterostructure.
Aortic valve surgery in osteogenesis imperfecta: report of two cases and review of the literature. (1998)

Aortic insufficiency is a well known but uncommon valvular dysfunction in patients with osteogenesis imperfecta. In such cases, aortic valve surgery has rarely been performed, and carries a high risk of perioperative complications. We report two patients with osteogenesis imperfecta, who underwent elective successful aortic valve replacement. The surgical problems encountered in this connective tissue disorder are also reviewed.
A traveller with haemoptysis – Answers (2011)

Further investigations revealed a negative autoimmune screen and aspergillus preciptins, but a raised total IgE level of 350ku/l. She underwent a bronchoscopy and lavage which was negative for routine culture and acid-fast bacilli, and revealed a normal cell differential.
Design of microfluidic sample preconditioning systems for detection of biological agents in environmental samples (1998)

Monitoring of biologically active agents such as bacteria, viruses, proteins and small molecules in environmental samples poses complex analytical problems. The particulate nature of the analytes and potential interferents is of particular concern for microfluidic systems in which the channels may not be much larger than the particles themselves. For this reason, sample preconditioning upstream of a chemical analytical device will usually be required. However, the small dimensions of microfluidic devices also allow unique methods of sample purification, concentration, and detection. In our laboratory we have developed a series of microfluidic chemical analytical devices for such purposes. These devices rely on the low Reynolds number flow conditions. In such conditions field flow fractionation based on sedimentation, diffusion and electrophoresis perpendicular to the flow direction can be profitably harnessed to precondition samples. The H-filter is one such device in which a simple 4-port device that allows two fluids to be brought into adjacent flow, and then separated downstream into two (or more) flow streams after exchange of material under the influence of one or more fields. It can be fabricated using anodically bonded silicon and Pyrex channels, or using polymeric devices formed using `soft lithography' techniques. We have tested the ability of this device to be used for purification of bacteria and their spores from complex samples containing silica and other interferent particles. We will present results of our tests of this device, as well as initial attempts to integrate the H-filter into a sample preconditioning system that includes on-chip pumps.
Elevated plasma concentration of complement factor C5 is associated with risk of future venous thromboembolism (2021)

The role of complement in the pathogenesis of venous thromboembolism (VTE) is unclear. We wanted to investigate (1) whether plasma complement component C5 (C5) levels are influenced by genetic variants or chronic inflammation and (2) the association between plasma C5 and risk of future VTE in a nested case-control study of 415 patients with VTE and 848 age- and sex-matched controls derived from the Tromsø Study. Plasma C5 levels were measured at inclusion. Odds ratios (ORs) with 95% confidence intervals (95% CIs) for provoked and unprovoked VTE across tertiles of C5 concentrations were estimated by logistic regression. Adjustment for C-reactive protein (CRP) served as a proxy for general inflammation. Whole-exome sequencing and protein quantitative trait loci analyses were performed to assess genetic influence on C5 concentrations. There was no association between genome-wide or C5-related gene variants and C5 levels. The association between plasma C5 levels and VTE risk displayed a threshold effect, where subjects with C5 levels above the lowest tertile had increased risk of VTE. Subjects in tertile 3 (highest C5 levels) had an age- and sex-adjusted OR of 1.45 (95% CI, 1.07-1.96) compared with tertile 1 (lowest). These statistics were more pronounced for unprovoked VTE (OR, 1.70; 95% CI, 1.11-2.60). Adjustments for body mass index and CRP had minor impact on risk estimates. The OR increased substantially with shorter time between blood sampling and VTE event. In conclusion, plasma C5 was associated with risk of future VTE. C5 levels were not genetically regulated and were only slightly influenced by chronic inflammation.
Protease Activation During HIV Infection in a CD4-Positive Cell Line (1990)

The mechanism of cytopathic effects associated with HIV infection in a continuous line of CD4-positive lymphocytes (CEM cells, clone 13) has been studied. Here we report the following observations: (1) HIV infection killed a variable but always significant number of cells without a strict relationship with the syncytia formation; (2) an important decrease in the proliferation rate occurred soon after infection; (3) a marked inhibition of protein synthesis took place within the first few hours of infection and clearly before the beginning of viral protein expression. In addition, when three-day-old cultures were incubated in serum-free medium, a larger degradation of proteins was observed in infected cells in comparison to controls. An increase in protein degradation activity was observed also in vitro with extracts obtained from HIV-infected cells and incubated in the presence of endogenous- or exogenous-labeled substrates. Extracts from cells infected with heat-inactivated HIV did not show a similar degradative activity. The possible induction or activation of latent proteases during the development of the HIV infection is discussed.
Power budget considerations in CWDM/TDM based Passive Optical Networks (2008)

The challenges for the current PON standards as well as their future extensions and impairments are studied in this paper. We present a link design for a CWDM/TDM PON that includes 100 ONUs, each with average bit rates of 100 Mbit/s and 25 Mbit/s for downstream and upstream transmission, respectively.
Research Priorities for Interventions to Address Health Disparities in Lung Nodule Management: An Official American Thoracic Society Research Statement (2023)

<b>Background:</b> Lung nodules are common incidental findings, and timely evaluation is critical to ensure diagnosis of localized-stage and potentially curable lung cancers. Rates of guideline-concordant lung nodule evaluation are low, and the risk of delayed evaluation is higher for minoritized groups. <b>Objectives:</b> To summarize the existing evidence, identify knowledge gaps, and prioritize research questions related to interventions to reduce disparities in lung nodule evaluation. <b>Methods:</b> A multidisciplinary committee was convened to review the evidence and identify key knowledge gaps in four domains: <i>1</i>) research methodology, <i>2</i>) patient-level interventions, <i>3</i>) clinician-level interventions, and <i>4</i>) health system-level interventions. A modified Delphi approach was used to identify research priorities. <b>Results:</b> Key knowledge gaps included <i>1</i>) a lack of standardized approaches to identify factors associated with lung nodule management disparities, <i>2</i>) limited data evaluating the role of social determinants of health on disparities in lung nodule management, <i>3</i>) a lack of certainty regarding the optimal strategy to improve patient-clinician communication and information transmission and/or retention, and <i>4</i>) a paucity of information on the impact of patient navigators and culturally trained multidisciplinary teams. <b>Conclusions:</b> This statement outlines a research agenda intended to stimulate high-impact studies of interventions to mitigate disparities in lung nodule evaluation. Research questions were prioritized around the following domains: <i>1</i>) need for methodologic guidelines for conducting research related to disparities in nodule management, <i>2</i>) evaluating how social determinants of health influence lung nodule evaluation, <i>3</i>) studying approaches to improve patient-clinician communication, and <i>4</i>) evaluating the utility of patient navigators and culturally enriched multidisciplinary teams to reduce disparities.
MEMS-Based Reconfigurable RF Circuits for Future Mobile Terminals (2007)

Reconfigurable radio frequency (RF) circuits will be the predominant solution for future mobile terminals. Recent progress in RF-microelectromechanical systems (MEMS) devices has bolstered the hope for the implementation of high-performance reconfigurable RF circuits. This paper presents configurations for a novel band-reconfigurable power amplifier, a reconfigurable isolator, and a resonator for a center frequency and bandwidth tunable filter. These RF circuits were prototyped. The reconfigurable power amplifier using MEMS switches achieves comparable performance to that of a single-band power amplifier in four different frequency bands. The isolator and the resonator prototypes confirm the feasibility of the proposed configuration. These reconfigurable RF circuits will contribute to band-free operation in future mobile terminals.
Time-dependent Diffusion in Transient Splenial Lesion: Comparison between Oscillating-gradient Spin-echo Measurements and Monte-Carlo Simulation (2020)

The microstructural underpinnings of reduced diffusivity in transient splenial lesion remain unclear. Here, we report findings from oscillating gradient spin-echo (OGSE) diffusion imaging in a case of transient splenial lesion. Compared with normal-appearing white matter, the splenial lesion exhibited greater differences between diffusion time t = 6.5 and 35.2 ms, indicating microstructural changes occurring within the corresponding length scale. We also conducted 2D Monte-Carlo simulation. The results suggested that emergence of small and non-exchanging compartment, as often imagined in intramyelinic edema, does not fit well with the in vivo observation. Simulations with axonal swelling and microglial infiltration yielded results closer to the in vivo observations. The present report exemplifies the importance of controlling t for more specific radiological image interpretations.