gebhart/patrepeval huggingface dataset:
Abstract 5387: ONC201/TIC10 is effective as a monoagent and synergizes with chemotherapy to induce cell death in non-Hodgkin's lymphoma (2015)

Abstract Outcome for non-Hodgkin's lymphoma (NHL) patients using conventional treatment standards remains unsatisfactory, particularly in advanced stage/ relapsed disease creating an imminent need for investigating novel treatment strategies. ONC201/TIC10 is a small molecule (Allen et al, 2013) that induces p53-independent cell death in tumor cells while sparing normal cells through inactivation of the prosurvival kinases Akt and ERK. ONC201 is currently entering Phase I/II clinical trials as a monoagent in adult advanced cancers. We have previously shown that ONC201 induces significant cytotoxicity in preclinical models of human lymphomas (Talekar et al, ASPHO 2014). Here, we show that ONC201 is not only effective as a monoagent across several NHL cell lines, but that it also synergizes with several chemotherapeutic agents to cooperatively induce cell death in vitro. We found that ONC201 induces significant apoptosis in a diverse panel of human NHL cell lines at low micromolar concentrations (1.3 to 5.06 uM). Increased surface TRAIL and surface DR5 expression was noted in a dose-dependent manner across representative cell lines. The increase in surface TRAIL correlated with increase in sub-G1 DNA content, which suggests that TRAIL may serve as a potential biomarker of response to ONC201. ONC201-induced apoptosis was inhibited using a pan-caspase inhibitor and was blocked by an anti-TRAIL antibody RIK-2, which indicate induction of TRAIL-dependent cell death. Western blot analysis of ONC201-treated NHL cells suggests ERK inhibition and Foxo3a activation as a potential mechanism of cytotoxicity via TRAIL induction. In agreement with this notion, we also observed upregulation of PARP &amp; DR5 and caspase-3 activation in response to ONC201 treatment. We further found that ONC201 synergizes to potentiate cytotoxicity with several chemotherapeutic agents approved for NHL treatment, particularly anthracyclines (doxorubicin), nitrogen mustard (bendamustine), antimetabolite (cytarabine) and proteasome inhibitor (bortezomib) via cell viability experiments that were corroborated by apoptosis assays. Together these results suggest that ONC201 is a potent antitumor agent in NHL as monoagent and in combination with several approved therapies that may be explored in phase Ib/II trials. Citation Format: Mala Kiran Talekar, David Dicker, Joshua Allen, Wafik El-Deiry. ONC201/TIC10 is effective as a monoagent and synergizes with chemotherapy to induce cell death in non-Hodgkin's lymphoma. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 5387. doi:10.1158/1538-7445.AM2015-5387
Adaptive noise cancellation with directional microphones (2002)

The spatial correlation function between directional microphones is useful in the design and analysis of the performance of these microphones in actual acoustic noise fields. These correlation functions are well known for omnidirectional receivers, but not well known for directional receivers. This paper investigates the spatial correlation functions for N/sup th/-order differential microphones in spherically isotropic noise fields. The results are used to calculate the amount of achievable cancellation from an adaptive noise cancellation application using combinations of differential microphones to remove unwanted noise from a desired signal. The results are also useful in determining signal-to-noise ratio gains from arbitrarily positioned differential microphone elements in microphone array applications.
Phenothiazine-Bridged Cyclic Porphyrin Dimers as High-Affinity Hosts for Fullerenes and Linear Array of C60in Self-Assembled Porphyrin Nanotube (2014)

Free-bases and a nickel(II) complex of phenothiazine-bridged cyclic porphyrin dimers bearing self-assembling 4-pyridyl groups (M2-Ptz-CPDPy(OCn); M = H2 or Ni, OCn = OC6 or OC3) at opposite meso-positions have been prepared as host molecules for fullerenes. The free-base dimer (H4-Ptz-CPDPy(OC6)) includes fullerenes with remarkably high association constants such as 3.9 ± 0.7 × 10(6) M(-1) for C60 and 7.4 ± 0.8 × 10(7) M(-1) for C70 in toluene. This C60 affinity is the highest value ever among reported receptors composed of free-base porphyrins. The nickel dimer (Ni2-Ptz-CPDPy(OC6)) also shows high affinities for C60 (1.3 ± 0.2 × 10(6) M(-1)) and C70 (over 10(7) M(-1)). In the crystal structure of the inclusion complex of C60 within H4-Ptz-CPDpy(OC3), the C60 molecule is located just above the centers of the porphyrins. The two porphyrin planes are almost parallel to each other and the center-to-center distance (12.454 Å) is close to the optimal separation (∼12.5 Å) for C60 inclusion. The cyclic porphyrin dimer forms a nanotube through its self-assembly induced by C-H···N hydrogen bonds between porphyrin β-CH groups and pyridyl nitrogens as well as π-π interactions of the pyridyl groups. The C60 molecules are linearly arranged in the inner channel of this nanotube.
Improved synthesis of cubane-1,2,4,7-tetracarboxylic acid [Erratum to document cited in CA114(9):81088g] (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleImproved synthesis of cubane-1,2,4,7-tetracarboxylic acid [Erratum to document cited in CA114(9):81088g]Jeffrey C. Bottaro, Paul E. Penwell, and Robert J. SchmittCite this: J. Org. Chem. 1991, 56, 15, 4816Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/jo00015a053https://doi.org/10.1021/jo00015a053research-articleACS PublicationsRequest reuse permissionsArticle Views77Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Abstract P411: Sex-based Differences In A Feline Model Of Hfpef (2021)

Rationale: Heart Failure with preserved Ejection Fraction (HFpEF) accounts for approximately 50% of all HF diagnoses with no FDA approved therapies. HFpEF is more prevalent in females versus males, but the mechanisms driving the development of HFpEF as a sex-based disorder are not well understood. We have recently shown that slow progressive pressure overload (PO) in male felines induces a HFpEF phenotype but have not investigated the differences in response to the same physiological stress in females. Hypothesis: Females will develop a phenotype that is distinct from males in response to PO. Methods and Results: Male (m) and female (f) domestic short felines (age 2mo) underwent either a sham procedure (m: n=7; f: n=7) or aortic constriction (m: n=11; f: n=10) using a customized pre-shaped band. At baseline (prior to surgery), there was no difference in body weight between groups and echocardiography revealed no significant difference in the ratio of left atrium to aortic root (LA/Ao), LA ejection fraction (LA EF), left ventricle (LV) ejection fraction, LV wall-thickness, and E/A ratio. At 4mo post-surgery, both males and females developed cardiac dysfunction. Females gained significantly less weight than males throughout the study. Despite the size difference, both sexes developed comparable LV wall thickness and changes in E/A ratio vs. sham groups. There was no change in LV EF. Furthermore, there was a decrease in LA EF and increased LA/Ao, indicating LA dysfunction and enlargement. Invasive hemodynamics at 4mo post-surgery showed no differences between sexes for the systolic pressure gradient generated by the aortic banding. Banded males had a significantly higher LV end-diastolic pressure vs. banded females, but there was a trend towards prolongation of tau and lower dp/dt min in banded females, reflective of worse active relaxation. Both sexes had comparable dP/dt max . There were no differences between banded males and females in heart weight to body weight or cardiomyocyte cross-sectional area. Conclusion: Despite similar pressure gradients as a result of PO and the development of similar cardiac hypertrophy between sexes and a higher LVEDP in males, females had a trend towards worse relaxation. Other causes of HFpEF may have sex-based differences.
45‐3: Late‐News Paper: Homogeneous Alignment LCDs Could be Prime Candidate for Multiple Scene Interactive Interface and Devices (2020)

When more and more display devices are used as interaction interface, touch has been essential function integrated in display devices. Homogeneous alignment LCDs and full in cell touch technology has been developed and applied on mobile phone, tablet PC, notebook PC, Monitor and even TV scale. In this paper, we made a comparison on different display technology in the point of not only display specification but also human experience. ADS type homogeneous alignment LCDs would keep its major position in small and middle size market and expand share on big size in furtherfollowing the development of interaction devices.
Alkylidyne(carbaborane) complexes of the Group 6 metals. Part 1. Proton-induced alkylidyne ligand migration (1992)

Treatment of carbon monoxide-saturated solutions of the salts [NEt4][W(CR)(CO)2(η5-C2B9H9Me2)](R = C6H4Me-4 or Me) at ca.–78 °C with HBF4·Et2O affords the complexes [W(CO)4{η5-C2B9H8(CH2R)Me2}]. If these protonation reactions are carried out in the presence of PhCCPh, the alkynetungsten complexes [W(CO)(PhC2Ph)2{η5-C2B9H8(CH2R)Me2}] are formed via the intermediacy of dicarbonyl species [W(CO)2(PhC2Ph)2{η5-C2B9H8(CH2R)Me2}]. The latter (R = C6H4Me-4) with PMe3 yields the compound [W(CO)(PMe3)(PhC2Ph){η5-C2B9H8(CH2C6H4Me-4)Me2}]. Treatment of [NEt4][W (CC6H4Me-4)(CO)2(η5-C2B9H9Me2)] with HBF4·Et2O in the presence of CNBut yields [W(CO)2(CNBut)2{η5-C2B9H8(CH2C6H4Me-4)Me2}], whereas if PPh3 is used instead of CNBut a tricarbonyl species [W(CO)3(PPh3){η5-C2B9H8(CH2C6H4Me-4)Me2}] is isolated. However, the latter disproportionates in solution to afford the bis(triphenylphosphine) complex [W(CO)2(PPh3)2{η5-C2B9H8(CH2C6H4Me-4)Me2}], crystals of which have been analysed by X-ray crystallography. The tungsten atom is η5 co-ordinated by the C2B9H8(CH2C6H4Me-4) Me2 ligand and is ligated by two CO and two PPh3 groups, having transoid arrangements. The CH2C6H4Me-4 substituent on the cage is bonded to the boron atom which is in the β site with respect to the two carbons in the open pentagonal [graphic omitted] face of the nido-icosahedral C2B9 fragment. This geometry accounts for the NMR data (1H, 13C-{1H} and 11B-{1H}) for all the new complexes reported containing the C2B9H8(CH2R)Me2 cage system.
Temperature dependence of practical τ-Vminmode FLC materials (2000)

Abstract We developed the practical τ-V min mode ferroelectric liquid crystal (FLC) material with large dielectric anisotropies Δϵ=3.5 and ∂ϵ=7.4 to obtain the wide operating voltage range, and with the temperature-independent switching threshold voltage V k=37 V to obtain the wide operating temperature range. This material performs the fast line address time 12 μs/line and shows higher contrast ratio than 200:1 under practical operating waveforms. This kind of material is suitable for the multiplexed passive-matrix FLC displays showing full color moving images due to the high bit temporal dither technique.
Surface Stabilization and Dissolution Rate Improvement of Amorphous Compacts with Thin Polymer Coatings: Can We Have It All? (2020)

The distinction between surface and bulk crystallization of amorphous pharmaceuticals, as well as the importance of surface crystallization for pharmaceutical performance, is becoming increasingly evident. An emerging strategy in stabilizing the amorphous drug form is to utilize thin coatings at the surface. While the physical stability of systems coated with pharmaceutical polymers has recently been studied, the effect on dissolution performance as a function of storage time, as a further necessary step toward the success of these formulations, has not been previously studied. Furthermore, the effect of coating thickness has not been elucidated. This study investigated the effect of these polymer-coating parameters on the interplay between amorphous surface crystallization and drug dissolution for the first time. The study utilized simple tablet-like coated dosage forms, comprising a continuous amorphous drug core and thin polymer coating (hundreds of nanometers to a micrometer thick). Monitoring included analysis of both the solid-state of the model drug (with SEM, XRD, and ATR FTIR spectroscopy) and dissolution performance (and associated morphology and solid-state changes) after different storage times. Stabilization of the amorphous form (dependent on the coating thickness) and maintenance of early-stage intrinsic dissolution rates characteristic for the unaged amorphous drug were achieved. However, dissolution in the latter stages was likely inhibited by the presence of a polymer at the surface. Overall, this study introduced a versatile coated system for studying the dissolution of thin-coated amorphous dosage forms suitable for different drugs and coating agents. It demonstrated the importance of multiple factors that need to be taken into consideration when aiming to achieve both physical stability and improved release during the shelf life of amorphous formulations.
Preliminary results of channel characterization at 700MHz band in urban and rural regions (2014)

This paper presents the preliminary results of channel characterization in the 700 MHz band, based on measurements of an OFDM modulated signal in urban and rural environments. This band will be used for mobile wideband communications in Brazil. An investigation of the dispersion parameters of the channel was carried out in the two different environments aiming a comparison between results of mean excess delay and RMS delay spread, useful for systems design.
Low-Loss Intermateability of APC-MPO Connectors Between Different Material and Different Guide Hole Diameter Plugs (2010)

Low-loss intermateability design of SM-APC-MPO connector was studied. Plugs of different dimensions for guide hole diameters, different materials and different Yoffset values demonstrated low-loss intermateability of less than 0.25 [dB] for 97% value.
TMTI Task 1.6 Genetic Engineering Methods and Detection (2009)

A large number of GE techniques can be adapted from other microorganisms to biothreat bacteria and viruses. Detection of GE in a microorganism increases in difficulty as the size of the genetic change decreases. In addition to the size of the engineered change, the consensus genomic sequence of the microorganism can impact the difficulty of detecting an engineered change in genomes that are highly variable from strain to strain. This problem will require comprehensive databases of whole genome sequences for more genetically variable biothreat bacteria and viruses. Preliminary work with microarrays for detecting synthetic elements or virulence genes and analytic bioinformatic approaches for whole genome sequence comparison to detect genetic engineering show promise for attacking this difficult problem but a large amount of future work remains.
CMOS-MEMS probes for reconfigurable IC&#x2019;s (2008)

We report on our progress on the development of CMOS-MEMS electrothermal conductive probes for memory-intensive self-configuring integrated circuits (MISCICs). The MISCIC vision is to use MEMS conductive probes to reconfigure circuits by mechanically addressing and passing current through resistance change vias embedded within the chip circuitry. Cantilevered probes are designed with 1, 4, 9, 16 and 25 mum <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> areas that are plated with nickel. The vertical range of the electrothermal actuator is 23.9 mum with 3.7 mW heating power, but the range is reduced when in contact with a gold-coated glass slide due to thermal effects. Probe contact to gold varies from 10-50 Omega for multiple make and break cycles with 1 mum <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> tips.
12.2: Flame‐Resistant and Heat‐Resistant Lithium‐Ion Battery Used to Operate Heat‐Resistant OLED (2015)

A flame‐ and heat‐resistant lithium‐ion battery (LIB) has been developed using ionic liquid electrolyte. This battery can be stably discharged at 100°C as well as at 0°C. A heat‐resistant organic light‐emitting diode (OLED) using this battery as a power source has been stably operated at temperatures of 100°C and 0°C.
Methylprednisolone Therapy of Deceased Donors Could Improve Clinical Outcome after Kidney Transplantation (2012)

Introduction: The brain death of deceased donors has been identified as an antigen independent risk factor for the clinical outcome after transplantation. Beside brain death, hemodynamic, hormonal and immunological changes in the donor are observed which have a negative influence on graft quality. Treatment of the donor could avoid harmful changes in organs suitable for transplantation following brain death. The influence of methylprednisolone therapy of deceased donors on the outcome after kidney transplantation was investigated in this prospective randomized study. Methods: Deceased donors from the region of Berlin-Brandenburg (Germany) were prospectively randomized in 2 groups. One group (n=25) was treated after brain death diagnosis initially with 250mg methylprednisolone intravenously, followed by a continuous administration of 100mg/h methylprednisolone until donor surgery. The control group (n=27) was not treated with methylprednisolone. Clinical data of the recipients were analyzed to characterize the clinical outcome after kidney transplantation up to 12 months. Results: Serum urea concentrations of patients with kidney grafts after methylprednisolone therapy were lower at all investigated time points compared to the control group (significant on the 10th day and after 3 months). Potassium concentration (significant on the 7th day after transplantation) and phosphate concentration (significant on the 10th day and after 3, 6 and 12 months) were also decreased compared to controls. Moreover, albeit not significant creatinine concentration was reduced compared with controls at all time points. A lower rate of acute rejections (32% vs. 44%) with a trend to lower grad rejections and a reduced number of rejection events were found after methylprednisolone treatment in the first year after kidney transplantation. The number of graft failure (8% vs. 15%) in the first year was lower in the group with pretreated kidneys. Conclusion: Pretreatment of the deceased donor with methylprednisolone may have a positive influence on the graft function after kidney transplantation. Recipients of pretreated kidneys present a favorable clinical outcome after kidney transplantation. The methylprednisolone therapy of deceased donors could contribute to a better graft quality, particular in marginal donors.
Mesoporous superacid catalysts for valorisation of refinery naphtha stream (2018)

In the current petroleum refining scenario, many refineries end up with surplus naphtha which is either absorbed into the gasoline pool or exported at unattractive prices. Therefore, several options for naphtha valorisation are currently being explored. The usage of Liquified Petroleum Gas (LPG) as a fuel in heating appliances, cooking equipment and automobiles is rapidly increasing. The high specific calorific value, high octane number, clean and efficient combustion of LPG distinguish it as an extremely promising fuel of the future. In the current work, tungstophosphoric acid (TPA) supported on four different mesoporous silica supports were investigated as mesoporous superacids for hydroconversion of refinery naphtha using <i>n</i>-heptane as a model feedstock. The varied levels of interactions of prepared mesoporous silica with tungstophosphoric acid catalysts were observed to have a prominent effect on the strength of the acid sites generated on silica surfaces and as a result affected heptane hydroconversion activity and selectivity of isomerized and cracked products. Interestingly, activity could be tuned towards selective cracking or isomerization-cracking by selection of a suitable topology of mesoporous silica. Hexagonal Mesoporous Silica (HMS) and plugged SBA-15 supported TPA catalysts demonstrated high <i>n</i>-heptane conversion activity and isomerization selectivity whereas KIT-6 and SBA-15 supported TPA catalysts demonstrated high cracking selectivity to LPG.
Low Levels of IFN-γ Down-regulate the Integrin-dependent Adhesion of B Cells by Activating a Pathway That Interferes with Cytoskeleton Rearrangement (2001)

In order to fully mature and participate in the humoral immune response, immature B cells must first migrate into specific areas in the spleen where they differentiate into mature cells. However, before their maturation in the spleen, immature B cells must be excluded from non-splenic secondary lymphoid organs where any antigen encounter would lead to the death of the cells because of the negative selection process. We have recently shown that immature B cells can actively exclude themselves from antigen-enriched sites by down-regulating their integrin-mediated adhesion in a process mediated by interferon-gamma (IFN-gamma). In this study, we followed the pathway by which IFN-gamma regulates the homing of B cells. We show here that the inhibitory signal of IFN-gamma is transmitted through the IFN-gamma receptor whose engagement leads to the activation of PI3K. This PI3K activation subsequently leads to the inhibition of PKCalpha phosphorylation and cytoskeleton rearrangement required for promoting integrin-mediated adhesion and migration of B cells.
12-SRFSI relevant documents as per objectives (2020)

These reports were generated by CIMMYT and SRFSI project partners. The data were collected with the help from DAE, BARI, and RDRS in Bangladesh; ICAR, BAU, UBKV, DoA-WB, Shakhi and JEEViKA in India, NARC and DoA in Nepal and community-based organizations (CBOs) in the region and are thankfully acknowledged. The support received from CSIRO, Curtin University, University of Queensland, the University of New England in Australia; iDE Nepal; IRRI, IWMI, and IFPRI are also greatly appreciated. We thank the farmers, service providers, machinery dealers of EGPs for their co-operation and inputs in implementing on-farm trials. A tremendous progress has been made in achieving milestones/outputs set in the proposal. This level of achievements would not have been possible without collaborators and other stakeholders’ dedicated supports. Thanks, are also due to Australian Centre for International Agricultural Research (ACIAR) and the Department of Foreign Affair and Trade (DFAT) for the support of CASI technology development and delivery in the EGPs. This research synthesis report is an output from a collaborative regional multi-partnership project managed by CIMMYT with the ACIAR and DFAT funding for the benefit of developing countries (CSE/2011/077). The views expressed are not necessarily those of these institutions or organizations.