gebhart/patrepeval huggingface dataset:
Mutational analysis of the HIV-1 auxiliary protein Vif identifies independent domains important for the physical and functional interaction with HIV-1 reverse transcriptase (2014)

The editors wish to alert the readers that questions have been raised about the validity of some of the figures presented in this article. The editors note that Figures Although this indicates incorrect scientific practice, we believe, having scrutinized the original data, that these manipulations do not affect the conclusions of this study, which appear to be still valid. Nonetheless,
Champions in Our Midst: Masters of DOCSIS (2014)

Welcome to the second of this new series of articles for IEEE Consumer Electronics Magazine. One of the benefits of joining the Consumer Electronics (CE) Society is that you get access to senior engineers and researchers from our industry. They are often at our conferences and workshops and at local Chapter meetings, and they frequently play an active role in the organization of Society activities.
Functionally distinct BMP1 isoforms show an opposite pattern of abundance in plasma from non-small cell lung cancer subjects and controls (2023)

Advancements in deep plasma proteomics are enabling high-resolution measurement of plasma proteoforms, which may reveal a rich source of novel biomarkers previously concealed by aggregated protein methods. Here, we analyze 188 plasma proteomes from non-small cell lung cancer subjects (NSCLC) and controls to identify NSCLC-associated protein isoforms by examining differentially abundant peptides as a proxy for isoform-specific exon usage. We find four proteins comprised of peptides with opposite patterns of abundance between cancer and control subjects. One of these proteins, BMP1, has known isoforms that can explain this differential pattern, for which the abundance of the NSCLC-associated isoform increases with stage of NSCLC progression. The presence of cancer and control-associated isoforms suggests differential regulation of BMP1 isoforms. The identified BMP1 isoforms have known functional differences, which may reveal insights into mechanisms impacting NSCLC disease progression.
Revolutionary NanoSilicon Ancillary Technologies for Ultimate-Performance Gigascale Systems (2007)

This paper describes electrical, optical, and fluidic (or 'trimodal') chip I/O interconnect networks for gigascale systems to meet and exceed end-of-roadmap projections in the areas of power delivery, off-chip bandwidth, and heat removal, respectively. The trimodal I/O technology is proposed to overcome the adverse effects of conventional silicon ancillary technologies on the performance of a gigascale system. We describe trimodal I/O interconnect configurations, fabrication, assembly, and testing.
Half Slave and Half Free: The Roots of Civil War. (1993)

Journal Article Half Slave and Half Free: The Roots of Civil War. By Bruce Levine. (New York: Hill and Wang, 1992. xii + 292 pp. Cloth, $30.00, ISBN 0-8090-5352-7. Paper, $11.95, ISBN 0-374-52309-6.) Get access Jane H. Pease Jane H. Pease University of Charleston, Charleston, South Carolina Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 80, Issue 1, June 1993, Pages 275–276, https://doi.org/10.2307/2079767 Published: 01 June 1993
Two-dimensional pH-responsive printable smectic hydrogels (2012)

Anisotropic swelling and deswelling of smectic liquid crystal networks have been observed in response to pH changes.
Effect Of Pulmonary Vein Isolations And Reconnections On P-wave Morphology in Atrial Fibrillation Patients. A Simulation Study (2019)

International audience
Microbubble-Enhanced Ultrasound Gene Transfer into Fibroblast Cells (2007)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Kota Hirayama, Yukio Kaneko, Yuichi Tei, Yoichiro Matsumoto; Microbubble‐Enhanced Ultrasound Gene Transfer into Fibroblast Cells. AIP Conf. Proc. 21 May 2007; 911 (1): 509–515. https://doi.org/10.1063/1.2744322 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
1P1-E26 Wearable Tactile Display using Ultrasonic Vibration (2010)

When we display the texture of virtual 3D objects, it is required to display both tactile and force information at the same time. Although some force displays are commercially available in order to display tactile information together with force information, a wearable tactile display should be realized. Hence this paper proposes a novel wearable tactile display aiming for the integration with force display. To realize such a device, we used the squeeze film effect for tactile display, occurred by an ultrasonic vibration. First, we developed an ultrasonic vibrator for tactile display. The ultrasonic vibrator is required to be small and produce enough force to display the texture. Then, we develop a wearable tactile display using the ultrasonic vibrator. Finally, we verified the usability of the wearable tactile display by experiments.
Volumetric Analysis of Hearing-Related Structures of Brain in Children with GJB2-Related Congenital Deafness (2022)

Background: Children with non-syndromic hereditary sensorineural hearing loss (SNHL) provide an opportunity to explore the impact of hearing on brain development. Objective: This study investigates volumetric differences of key hearing-related structures in children with gap junction protein beta 2 GJB2-related SNHL compared to controls. Materials and methods: Ninety-four children with SNHL (n = 15) or normal hearing (n = 79) were studied using automated volumetric segmentation. Heschl’s gyrus (HG), anterior HG (aHG), planum temporale (PT), medial geniculate nucleus (MGN), and nucleus accumbens (NA) were analyzed relative to total brain volume (TBV) at two different age groups: (1) 7−12 months and (2) 13 months−18 years. Two-sided t-tests were used to evaluate differences between groups. Differences were considered significant if p < 0.007. Results: Significantly smaller aHG-to-TBV ratios were found in 13-month-to-18-year-old patients (p < 0.0055). HG-, PT-, MGN-, and NA-to-TBV ratios were smaller in the same age group, without reaching a significant level. Conversely, HG- and NA-to-TBV were larger in the younger age group. No significant differences were found between the groups for age and TBV. Conclusions: In this exploratory volumetric analysis of key hearing-related structures, we observed age-related changes in volume in children with GJB2-related SNHL.
Transplantation: Immunogenetic and Clinical Aspects—Part II (1983)

The ultimate goal is not merely to find a better way of treating acute rejection; efforts are now concentrated on prophylactic immunosuppression with low-dose regimens of azathioprine and steroids. In the wings is cyclosporine, a fungal polypeptide that shows great promise in clinical trials. And on the horizon there is hope that monoclonal antibodies may hold the key to prevention.
Empagliflozin reduces kidney fibrosis and improves kidney function by alternative macrophage activation in rats with 5/6-nephrectomy (2022)

A full list of funding bodies that contributed to this study can be found in the Acknowledgements section.
Biorenewable Polyelectrolyte Nanocoating for Flame-Retardant Cotton-Based Paper (2022)

Cotton-based raw paper, made of 100% cellulose, is used to make humidity-sensing, cottonid for bio-architecture applications. Despite its renewability and excellent mechanical properties, it is inherently flammable. In an effort to reduce its flammability, thin films of fully renewable and environmentally benign polyelectrolytes, chitosan (CH) and phytic acid (PA), were deposited on raw paper via layer-by-layer (LbL) assembly. Only four bilayers (BL) of the CH/PA coating are required to achieve self-extinguishing behavior, with a 69% reduction in peak heat release rate measured by microscale combustion calorimetry. These results demonstrate that this renewable intumescent LbL-assembled film provides an effective flame-retardant treatment for these environmentally friendly, climate-adaptive construction materials and could potentially be used to protect many cellulosic materials.
Segregation of Amine Oxide Surfactants in PVA Films (2020)

The vertical depth distributions of amine oxide surfactants, <i>N</i>,<i>N</i>-dimethyldodecyl amine <i>N</i>-oxide (DDAO) and <i>N</i>,<i>N</i>-dimethyltetradecyl amine <i>N</i>-oxide (DTAO), in poly(vinyl alcohol) (PVA) films were explored using neutron reflectometry (NR). In both binary and plasticized films, the two deuterated surfactants formed a single monolayer on the film surface with the remaining surfactant homogeneously distributed throughout the bulk of the film. Small-angle neutron scattering and mechanical testing revealed that these surfactants acted like plasticizers in the bulk, occupying the amorphous regions of PVA and reducing its glass-transition temperature. NR revealed little impact of plasticizer (glycerol) incorporation on the behavior of these surfactants in PVA. The surfactant molecular area in the segregated monolayer was smaller for DTAO than for DDAO, indicating that the larger molecule was more densely packed at the surface. Surface tension was used to assess the solution behavior of these surfactants and the effect of glycerol incorporation. Determination of molecular area of each surfactant on the solution surface revealed that the structures of the surface monolayers are remarkably consistent when water is placed by the solid PVA. Incorporation of glycerol caused a decrease of molecular area for DDAO and increase in molecular area for DTAO both in solution and in PVA. This suggests that the head group interactions, which normally limit the minimum area per adsorbed molecule, are modified by the length of the alkyl tail.
Fourier Transform and Vernier Spectroscopy with a Mid-Infrared Optical Frequency Comb (2016)

We present a versatile frequency comb spectroscopy system based on a doubly resonant optical parametric oscillator tunable between 3–5.4 μm and two detection methods: a Fourier transform spectrometer and a continuous-filtering Vernier spectrometer.
Expression of human cholesterol 7α-hydroxylase in atherosclerosis-susceptible mice via adenovirus infection (1997)

Adenovirus is a vector for the delivery of genes mainly to the liver. Short-term (approximately 3 days) studies using adenovirus transfection have provided valuable insights into how genes can complement normal and pathological phenotypes. When atherosclerosis-susceptible C57BL/6 mice were infected with an adenovirus vector containing the human 7alpha-hydroxylate cDNA (AV17h1) and fed on a chow diet, human 7alpha-hydroxylase mRNA and enzyme activity doubled compared with that in mice infected with an adenovirus vector (AV1Null) alone. In AV17h1-infected mice fed on a high fat cholic acid (HFCA) diet, mRNA expression and activity of both the endogenous and adenovirus (human) 7alpha-hydroxylase were repressed. AV17h1-infected mice fed on a HFCA diet and killed at mid-light had increased 7alpha-hydroxylase activity and mRNA compared with mice killed at mid-dark. Since expression of AV17h1 is driven by a constitutive Rous sarcoma virus promoter, the repression of human 7alpha-hydroxylase by the HFCA diet was unexpected. In spite of this post-transcriptional repression by the HFCA diet, AV17h1-infected mice expressed the human 7alpha-hydroxylase mRNA, causing its enzyme activity to be 3-fold greater than in AV1Null-infected mice. In AV17h1-infected mice, the 7alpha-hydroxylase enzyme activity varied as a linear function of human mRNA abundance. In conclusion, the accumulation of apolipoprotein B-containing lipoproteins in plasma of C57BL/6 mice fed on the HFCA diet was not reduced by longer-term (2 weeks) 7alpha-hydroxylase expression, probably because of its diminished expression caused by the diet and hepatic inflammation from the adenovirus infection. These results may suggest that adenovirus is effective in promoting longer-term (2 weeks) expression of 7alpha-hydroxylase.
Falling Short: Adverse Events Related to Patient Height (2021)

Measuring a patient’s height is a routine part of a healthcare encounter. But once completed, how often is this information used? For most of us who fall within 95% of the mean population height, this metric is rarely discussed, but what happens when it is overlooked? And what about those on the outer tails of the bell curve of population distribution? Almost 1 million (909,222) adults in the United States are at least 6'4", more than the entire population of South Dakota (884,659). Conversely, an estimated 30,000 Americans have a form of dwarfism, typically defined as an adult height no taller than 4'10". However, despite this prevalence, the healthcare system struggles to provide consistent, adequate care for patients with extreme heights. “Being tall is not a disease, but it is a consideration,” shared one 6' 3" woman, who descended from a long line of “Scottish Vikings.”* “I am one of the short ones at family reunions,” she continued; her father tops 6' 8". Experiences like hers prompted this investigation into the medical mishaps and trauma that have befallen those who are not “average-sized.”
High-speed modulator in zero-change CMOS photonics (2016)

A microring depletion modulator is demonstrated with T-shaped lateral p-n junctions used to realize efficient modulation while maximizing the RC limited bandwidth. The device having a 3 dB bandwidth of 13 GHz has been fabricated in a standard 45 nm microelectronics CMOS process. The cavity has a linewidth of 17 GHz and an average wavelength-shift of 9 pm/V in reverse-bias conditions.
Electronic metal-support interaction enhanced oxygen reduction activity and stability of boron carbide supported platinum (2017)

Catalysing the reduction of oxygen in acidic media is a standing challenge. Although activity of platinum, the most active metal, can be substantially improved by alloying, alloy stability remains a concern. Here we report that platinum nanoparticles supported on graphite-rich boron carbide show a 50-100% increase in activity in acidic media and improved cycle stability compared to commercial carbon supported platinum nanoparticles. Transmission electron microscopy and x-ray absorption fine structure analysis confirm similar platinum nanoparticle shapes, sizes, lattice parameters, and cluster packing on both supports, while x-ray photoelectron and absorption spectroscopy demonstrate a change in electronic structure. This shows that purely electronic metal-support interactions can significantly improve oxygen reduction activity without inducing shape, alloying or strain effects and without compromising stability. Optimizing the electronic interaction between the catalyst and support is, therefore, a promising approach for advanced electrocatalysts where optimizing the catalytic nanoparticles themselves is constrained by other concerns.
ChemInform Abstract: UNIMOLECULAR HETEROAROMATIC PHOTOINITIATORS (1984)

Abstract Aus den Säurechloriden (Ia) bzw. (IIa) entstehen die Persäureester (Ib) bzw. (lIb), die als Photoinitiatoren für die Polymerisation von Methylmethacrylat (III) eingesetzt werden.
ChemInform Abstract: 2‐((Alkylsulfonyl)oxy)‐6‐substituted‐1H‐isoindole‐1,3(2H)‐dione Mechanism‐Based Inhibitors of Human Leukocyte Elastase. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Correlation of Disorder and Charge Transport in a Range of Indacenodithiophene‐Based Semiconducting Polymers (2017)

Abstract Over the past 25 years, various design motifs have emerged for the development of organic semiconductors for demanding applications in flexible organic light emitting diode display backplanes or even printed organic logic. Due to their large area uniformity paired with high charge carrier mobilities, conjugated polymers have attracted increasing attention in this respect. However, the performances delivered by current generation conjugated polymers still fall short of many industrial requirements demanding devices with ideal transistor characteristics and higher mobilities. The discovery of conjugated polymers with low energetic disorder, such as the indacenodithiophene‐based polymer indacenodithiophene‐ co ‐benzothiadiazole, represent an exciting opportunity to breach this chasm if these materials can be further optimized while maintaining their low disorder. Here, it is shown how both the charge transport properties as well as the energetic disorder are affected by tuning the molecular structure of a large range of indacenodithiophene‐based semiconducting polymer derivatives. This study allows to understand better the interplay between molecular design and structure of the polymer backbone and the degree of energetic disorder that governs the charge transport properties in thin polymer films.
High-resolution Spatiotemporal Analysis of Receptor Dynamics by Single-molecule Fluorescence Microscopy (2014)

Single-molecule microscopy is emerging as a powerful approach to analyze the behavior of signaling molecules, in particular concerning those aspect (e.g., kinetics, coexistence of different states and populations, transient interactions), which are typically hidden in ensemble measurements, such as those obtained with standard biochemical or microscopy methods. Thus, dynamic events, such as receptor-receptor interactions, can be followed in real time in a living cell with high spatiotemporal resolution. This protocol describes a method based on labeling with small and bright organic fluorophores and total internal reflection fluorescence (TIRF) microscopy to directly visualize single receptors on the surface of living cells. This approach allows one to precisely localize receptors, measure the size of receptor complexes, and capture dynamic events such as transient receptor-receptor interactions. The protocol provides a detailed description of how to perform a single-molecule experiment, including sample preparation, image acquisition and image analysis. As an example, the application of this method to analyze two G-protein-coupled receptors, i.e., β2-adrenergic and γ-aminobutyric acid type B (GABAB) receptor, is reported. The protocol can be adapted to other membrane proteins and different cell models, transfection methods and labeling strategies.
A comparative study of robot languages (1982)

http://deepblue.lib.umich.edu/bitstream/2027.42/7577/5/bad2116.0001.001.pdf
Incidence of benign versus malignant renal tumors in selected studies. (2012)

357 Background: Use of cross-sectional imaging has increased the detection rate for small renal tumors; more patients now present with early-stage renal cell carcinoma (RCC) or benign or indolent renal masses. Histopathology after surgical resection is the definitive method for characterizing renal tumors. Stage migration of renal masses creates uncertainty about the percentage of resected masses that will be benign vs malignant. We sought to better define these proportions through a targeted review of the literature. Methods: PubMed/select congresses were searched to identify the histologic classification of renal masses in a representative sample from the contemporary literature: [search] incidence AND (renal cell carcinoma AND benign); incidence AND (renal tumor AND benign); percentage AND (renal cell carcinoma AND benign); limit: 2003–2011. Results: Most representative studies included procedures conducted in the mid-1990s to the mid-to-late 2000s. Studies origin was US (n=8), Korea (n=3), China, Japan, Germany, Austria, Australia, and multisite (Israel/France/US; all n=1). Only 8 studies had n≥500 (range, 70–10,404). The proportion of benign masses are shown (see Table); half of the studies reported values between 16% and 17%. The majority found that benign tumors were more likely to be smaller in size (&lt;4 or &lt;7 cm) than malignant tumors. 11 studies reported the RCC subtype (% clear cell range, 46%–83%). Conclusions: Benign renal tumors occur ~15% of the time and are more prevalent among small masses. Nearly 25% of resected lesions are benign or indolent and may not require surgery. Preoperative discrimination of more aggressive renal masses would be an important clinical advance that could improve clinicians’ diagnostic confidence and guide patient management. Funding: Wilex AG/IBA Molecular. [Table: see text]
Juxtaposed Color Halftoning Relying on Discrete Lines (2012)

Most halftoning techniques allow screen dots to overlap. They rely on the assumption that the inks are transparent, i.e., the inks do not scatter a significant portion of the light back to the air. However, many special effect inks, such as metallic inks, iridescent inks, or pigmented inks, are not transparent. In order to create halftone images, halftone dots formed by such inks should be juxtaposed, i.e., printed side by side. We propose an efficient juxtaposed color halftoning technique for placing any desired number of colorant layers side by side without overlapping. The method uses a monochrome library of screen elements made of discrete lines with rational thicknesses. Discrete line juxtaposed color halftoning is performed efficiently by multiple accesses to the screen element library.
Agent communication languages: rethinking the principles (1998)

Agent communication languages have been used for years in proprietary multiagent systems. Yet agents from different vendors-or even different research projects-cannot communicate with each other. The author looks at the underlying reasons and proposes a conceptual shift from individual agent representations to social interaction.
Interferon‐related mental deterioration after craniotomy for removal of metastatic renal cancer (2006)

Interferon-related severe adverse events on the central nervous system are relatively rare, because interferon-alpha (INF-alpha) can not cross an intact blood-brain barrier. We experienced remarkable mental deterioration caused by INF-alpha administration in a 43-year-old man with renal cell carcinoma after surgical removal of a metastatic brain tumor. We detected a high concentration of INF-alpha in a cerebrospinal fluid sample, which was comparable to that in the serum at 24 h after the administration of INF-alpha; 5x10(6) IU i.m., suggesting that the blood-brain barrier was damaged somehow by the craniotomy. The mental deterioration improved shortly after discontinuation of the INF-alpha administration.
Analysis of a multi-megawatt grid connected wind farm (2011)

Paper presented at the 8th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Mauritius, 11-13 July, 2011.