gebhart/patrepeval huggingface dataset:
Reboxetine Versus Fluvoxamine in the Treatment of Motor Vehicle Accident-related Posttraumatic Stress Disorder (2006)

Study observations indicate comparable efficacy of reboxetine and fluvoxamine in the management of MVA-related PTSD despite reboxetine's selective noradrenergic activity. Reboxetine appears to be at least as effective as fluvoxamine and may offer an alternative management option in this often difficult-to-treat and disabling condition. A lower and flexible reboxetine dosing schedule will be recommended for future research to improve its tolerability in PTSD patients.
Opal Crystals: Patterning Hierarchy in Direct and Inverse Opal Crystals (Small 12/2012) (2012)

This cover shows an optical image of a SiO2 ‘inverse opal’ fi lm having a combination of crystalline and localized quasi-ordered domains that are grown around a patterned hexagonal array of large posts. The contrast of colors corresponds to individual domains in the highly ordered, close-packed nanoporous film, due to Bragg diffraction as a photonic crystal. In this work, topographically patterned surfaces are designed to control the growth of direct and inverse colloidal photonic crystal films. As such, artificially imposed structures control the crystallographic domain nucleation and orientation, and modify the optical properties of these films. The close-packed colloids are forced to organize themselves around the curved surfaces of the posts, causing the nucleation of small domains. This method provides a bottom-up means of synthesizing complex, multi-layered, hierarchical direct and inverse opal structures with highly controlled optical properties and increased functionality. For more information, please refer to the Full Paper “Patterning Hierarchy in Direct and Inverse Opal Crystals” by J. Aizenberg and co-workers, beginning on page 1904.
p16INK4A Promotes Differentiation and Inhibits Apoptosis of JKB Acute Lymphoblastic Leukemia Cells (1997)

Homozygous p16(INK4A) (p16) gene deletion is frequent in primary tumor cells from acute lymphoblastic leukemia (ALL), suggesting that loss of p16 may be an important precursor to transformation in ALL. We have previously described JKB, a human ALL cell line, that contains homozygous deletion of the p16 gene. Because ectopic expression of p16 suppresses cell growth, we created a temperature sensitive p16 mutant to develop a system for inducible p16 function in human ALL. JKB cells were transfected either with a p16 gene mutated at position 119 (E119G) to confer temperature sensitivity (JKB p16MT) or with control vector. The percentage of cells in G1 phase was similar in JKB control cells or in JKB p16MT cells cultured at restrictive conditions (40 degrees C). However, with lowering of temperature from 40 degrees C to permissive conditions (31 degrees C), the percentage of JKB p16MT cells in G1 phase and binding of p16 to CDK4 and CDK6 increased, with associated decreases in CDK4 and CDK6 kinase activities, and dephosphorylation of retinoblastoma protein (pRB). Culture of JKB p16MT cells at 31 degrees C for >/=3 days irreversibly inhibited growth. Moreover, JKB p16MT cells cultured under these permissive conditions showed a less transformed morphology and more differentiated phenotype than did these cells cultured under restrictive temperatures. Finally, dexamethasone (Dex) induced apoptosis of JKB p16MT cells cultured at 40 degrees C, but did not trigger death of these cells cultured at 31 degrees C. These results suggest that deletion of p16 gene in JKB human ALL cells is associated with dysregulated growth of less differentiated tumor cells, which nonetheless remain susceptible to apoptosis triggered by Dex.
Determination of Decompression Wave Speed in Rich Gas Mixtures (2004)

Abstract Experimental data on the decompression wave speed of a conventional gas mixture and three other rich gas mixtures with varying C1 from 70 to 82% have been collected. An NPS 2 stainless steel expansion tube test rig has been constructed at TCPL Gas Dynamic Test Facility (GDTF) in Didsbury, AB, Canada, specifically for this task. Decompression wave was generated by a rupture disc at the end of the tube, which was instrumented with eight high frequency response pressure transducers located along the tube. The facility has the following three distinct capabilities: high initial pressures of up to 22 MPa, low initial temperature down to ‐20°C, and flexibility in testing any rich gas mixtures. The decompression wave speed data are presented in terms of the decompression expansion pressure ratio for all four gas mixtures and three initial line pressure of ∼ 10, 14 and 20 MPa. Comparison between experimentally obtained decompression wave speeds and those predicted by GASDECOM is also made for each test.
Determination of enantiomeric purity using chiral lanthanide shift reagents (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of enantiomeric purity using chiral lanthanide shift reagentsGeorge M. Whitesides and Daniel W. LewisCite this: J. Am. Chem. Soc. 1971, 93, 22, 5914–5916Publication Date (Print):November 1, 1971Publication History Published online1 May 2002Published inissue 1 November 1971https://pubs.acs.org/doi/10.1021/ja00751a066https://doi.org/10.1021/ja00751a066research-articleACS PublicationsRequest reuse permissionsArticle Views305Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Constant Weight Codes with Gabor Dictionaries and Bayesian Decoding for Massive Random Access (2022)

This paper considers a general framework for massive random access based on sparse superposition coding. We provide guidelines for the code design and propose the use of constant-weight codes in combination with a dictionary design based on Gabor frames. The decoder applies an extension of approximate message passing (AMP) by iteratively exchanging soft information between an AMP module that accounts for the dictionary structure, and a second inference module that utilizes the structure of the involved constant-weight code. We apply the encoding structure to (i) the unsourced random access setting, where all users employ a common dictionary, and (ii) to the "sourced" random access setting with user-specific dictionaries. When applied to a fading scenario, the communication scheme essentially operates non-coherently, as channel state information is required neither at the transmitter nor at the receiver. We observe that in regimes of practical interest, the proposed scheme compares favorably with state-of-the art schemes, in terms of the (per-user) energy-per-bit requirement, as well as the number of active users that can be simultaneously accommodated in the system. Importantly, this is achieved with a considerably smaller size of the transmitted codewords, potentially yielding lower latency and bandwidth occupancy, as well as lower implementation complexity.
TGF‐β1‐Stimulated Osteoblasts Require Intracellular Calcium Signaling for Enhanced α5 Integrin Expression (2002)

The osteoactive factor, transforming growth factor beta1 (TGF-beta1), influences osteoblast activity and bone function. We recently characterized a Smad-independent TGF-beta1-induced Ca(2+) signal in human osteoblasts (HOB) and demonstrated its importance in cell adhesion. Here, we further elucidate the role of the TGF-beta1 Ca(2+) signal in the mechanics of HOB adhesion. Osteoblast interaction with fibronectin (FN) through alpha5beta1 integrin is principally responsible for osteoblast-substrate adhesion. Our results show that the TGF-beta1 intracellular Ca(2+) signal is responsible, in part, for stimulation of alpha5 integrin expression, but not beta1 integrin or FN expression. Increased alpha5 integrin protein and mRNA expression was seen as early as 12 h after TGF-beta1 treatment, but was inhibited by cotreatment with nifedipine, a Ca(2+) channel blocker. TGF-beta1 increased both FN and beta1 integrin protein production within 48 h, independent of nifedipine cotreatment. Immunofluorescence observations revealed that TGF-beta1 increased alpha5 integrin staining, clustering, and colocalization with the actin cytoskeleton, effects that were blocked by nifedipine. The TGF-beta1 Ca(2+) signal, a pathway crucial for HOB adhesion, enhances alpha5 integrin expression, focal contact formation, and cytoskeleton reorganization. These early events are necessary for osteoblast adhesion; thus they determine the fate of the cell and ultimately affect bone function.
An Architecture to Accelerate Convolution in Deep Neural Networks (2017)

In the past few years, the demand for real-time hardware implementations of deep neural networks (DNNs), especially convolutional neural networks (CNNs), has dramatically increased, thanks to their excellent performance on a wide range of recognition and classification tasks. When considering real-time action recognition and video/image classification systems, latency is of paramount importance. Therefore, applications strive to maximize the accuracy while keeping the latency under a given application-specific maximum: in most cases, this threshold cannot exceed a few hundred milliseconds. Until now, the research on DNNs has mainly focused on achieving a better classification or recognition accuracy, whereas very few works in literature take in account the computational complexity of the model. In this paper, we propose an efficient computational method, which is inspired by a computational core of fully connected neural networks, to process convolutional layers of state-of-the-art deep CNNs within strict latency requirements. To this end, we implemented our method customized for VGG and VGG-based networks which have shown state-of-the-art performance on different classification/recognition data sets. The implementation results in 65-nm CMOS technology show that the proposed accelerator can process convolutional layers of VGGNet up to 9.5 times faster than state-of-the-art accelerators reported to-date while occupying 3.5 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Editorial: Focus on Ionization Technologies Used in MS: Fundamentals and Applications, Honoring Dr. Sarah Trimpin, Recipient of the 2019 ASMS Biemann Medal (2021)

ADVERTISEMENT RETURN TO ISSUEPREVEditorialNEXTEditorial: Focus on Ionization Technologies Used in MS: Fundamentals and Applications, Honoring Dr. Sarah Trimpin, Recipient of the 2019 ASMS Biemann MedalDavid H. Russell*David H. RussellDepartment of Chemistry, Texas A&M University, College Station, Texas 77843, United States*Email: [email protected]More by David H. Russellhttp://orcid.org/0000-0003-0830-3914 and David E. Clemmer*David E. ClemmerDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States*Email: [email protected]More by David E. Clemmerhttp://orcid.org/0000-0003-4039-1360Cite this: J. Am. Soc. Mass Spectrom. 2021, 32, 3, 616–617Publication Date (Web):March 3, 2021Publication History Received25 January 2021Accepted25 January 2021Published online3 March 2021Published inissue 3 March 2021https://pubs.acs.org/doi/10.1021/jasms.1c00030https://doi.org/10.1021/jasms.1c00030editorialACS PublicationsCopyright © 2021 American Society for Mass Spectrometry. Published by American Chemical Society. All rights reserved. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1053Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (2 MB) Get e-AlertscloseSUBJECTS:Alcohols,Ionization,Ions,Mass spectrometry,Vacuum Get e-Alerts
Sensitive and accurate identification of protein-DNA binding events in ChIP-chip assays using higher order derivative analysis (2010)

Immuno-precipitation of protein-DNA complexes followed by microarray hybridization is a powerful and cost-effective technology for discovering protein-DNA binding events at the genome scale. It is still an unresolved challenge to comprehensively, accurately and sensitively extract binding event information from the produced data. We have developed a novel strategy composed of an information-preserving signal-smoothing procedure, higher order derivative analysis and application of the principle of maximum entropy to address this challenge. Importantly, our method does not require any input parameters to be specified by the user. Using genome-scale binding data of two Escherichia coli global transcription regulators for which a relatively large number of experimentally supported sites are known, we show that ∼90% of known sites were resolved to within four probes, or ∼88 bp. Over half of the sites were resolved to within two probes, or ∼38 bp. Furthermore, we demonstrate that our strategy delivers significant quantitative and qualitative performance gains over available methods. Such accurate and sensitive binding site resolution has important consequences for accurately reconstructing transcriptional regulatory networks, for motif discovery, for furthering our understanding of local and non-local factors in protein-DNA interactions and for extending the usefulness horizon of the ChIP-chip platform.
Mid-frequency simultaneous switching noise in computer systems (2002)

CMOS microprocessors operating in the hundreds of megahertz create significant current deltas due to the variation in switching activity from clock cycle to clock cycle. In addition to the high-frequency voltage variations more commonly discussed, a lower frequency noise component is also produced that lasts from 50 to 200 ns which we refer to as mid-frequency noise. In this paper, we discuss the design of IBM's CMOS S/390 computer for control of mid-frequency noise. This machine has a 10-way multiprocessor on a 127 mm by 127 mm MCM on a FR4 board. The chips on the MCM cause a current step of tens of Amps in a few cycles that can be sustained for many cycles. The power distribution and decoupling capacitors must supply that current without disturbing the voltage level at the circuits. The design of the system power distribution and modeling and verification of mid-frequency noise in this system is presented.
Dynamic control of maximal ventricular elastance via the baroreflex and force-frequency relation in awake dogs before and after pacing-induced heart failure (2010)

We investigated to what extent maximal ventricular elastance (E(max)) is dynamically controlled by the arterial baroreflex and force-frequency relation in conscious dogs and to what extent these mechanisms are attenuated after the induction of heart failure (HF). We mathematically analyzed spontaneous beat-to-beat hemodynamic variability. First, we estimated E(max) for each beat during a baseline period using the ventricular unstressed volume determined with the traditional multiple beat method during vena cava occlusion. We then jointly identified the transfer functions (system gain value and time delay per frequency) relating beat-to-beat fluctuations in arterial blood pressure (ABP) to E(max) (ABP-->E(max)) and beat-to-beat fluctuations in heart rate (HR) to E(max) (HR-->E(max)) to characterize the dynamic properties of the arterial baroreflex and force-frequency relation, respectively. During the control condition, the ABP-->E(max) transfer function revealed that ABP perturbations caused opposite direction E(max) changes with a gain value of -0.023 +/- 0.012 ml(-1), whereas the HR-->E(max) transfer function indicated that HR alterations caused same direction E(max) changes with a gain value of 0.013 +/- 0.005 mmHg.ml(-1).(beats/min)(-1). Both transfer functions behaved as low-pass filters. However, the ABP-->E(max) transfer function was more sluggish than the HR-->E(max) transfer function with overall time constants (indicator of full system response time to a sudden input change) of 11.2 +/- 2.8 and 1.7 +/- 0.5 s (P < 0.05), respectively. During the HF condition, the ABP-->E(max) and HR-->E(max) transfer functions were markedly depressed with gain values reduced to -0.0002 +/- 0.007 ml(-1) and -0.001 +/- 0.004 mmHg.ml(-1).(beats/min)(-1) (P < 0.1). E(max) is rapidly and significantly controlled at rest, but this modulation is virtually abolished in HF.
Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid-anchored membrane proteins (1993)

The receptor for human urokinase-type plasminogen activator (uPAR) is synthesized as a 313-residue-long polypeptide containing 28 cysteine residues, the pattern of which defines three homologous repeats within the protein. These entities are believed to represent a novel protein domain structure, of which the NH2-terminal domain of uPAR can be covalently cross-linked to the epidermal growth factor-like module of urokinase after receptor-ligand interaction. The NH2-terminal domain of a recombinant, soluble uPAR derivative, labeled with [35S]cysteine, was isolated after limited proteolysis with chymotrypsin. The four disulfide bonds present within this domain were assigned by a combination of plasma desorption mass spectrometry, amino acid composition, and sequence analyses of peptides generated by trypsin, endoproteinase Asp-N, and thermolysin. The following disulfide bond structure was determined: Cys3-Cys24, Cys6-Cys12, Cys17-Cys45, and Cys71-Cys76. Similar cysteine pairing is likely to be found within other members of this protein superfamily, i.e. the membrane inhibitor of reactive lysis, Ly-6, and the remaining two domains of uPAR. However, an additional pair of cysteines present within these domains probably forms a fifth disulfide bond.
A Proline-based Macrocyclic Amide with S4 Symmetry (2007)

Abstract A new square-shaped macrocyclic amide was prepared from N-(4-amino-2-nitrophenyl)proline (ANPP). The two enantiomers of ANPP were connected in an alternating sequence and then cyclized to the corresponding macrocyclic tetramer with S4 symmetry. In this design, there is a central cavity approximately 7 Å in diameter and rigid aromatic rings and intramolecular hydrogen bonding help to reduce the conformational flexibility of the molecule.
Towards a fibrous composite with dynamically controlled stiffness: lessons from echinoderms (2000)

Sea urchins and sea cucumbers, like other echinoderms, control the tensile properties of their connective tissues by regulating stress transfer between collagen fibrils. The collagen fibrils are spindle-shaped and up to 1 mm long with a constant aspect ratio of approx. 2000. They are organized into a tissue by an elastomeric network of fibrillin microfibrils. Interactions between the fibrils are regulated by soluble macromolecules that are secreted by local, neurally controlled, effector cells. We are characterizing the non-linear viscoelastic properties of sea cucumber dermis under different conditions, as well as the structures, molecules and molecular interactions that determine its properties. In addition, we are developing reagents that will bind covalently to fibril surfaces and reversibly form cross-links with other reagents, resulting in a chemically controlled stress-transfer capacity. The information being developed will lead to the design and construction of a synthetic analogue composed of fibres in an elastomeric matrix that contains photo- or electro-sensitive reagents that reversibly form interfibrillar cross-links.
Reconfigurable true-time delay for wideband phased-array antennas (2004)

A novel reconfigurable true-time delay feed for phased-array antennas working from X to Q (8-50GHz) frequency bands is presented. The reconfigurable optical true-time delay feed, employing monolithic integration of polymer waveguide delay lines and polymeric optical switches, has great advantages in providing power efficient, lightweight, and small size features. Optical switch technique provides large delay selections enabling the module to operate in ultra-broad radar bands. Polymer waveguides with optical propagation loss of less than 0.9dB/cm were achieved at 1550nm. 2X2 thermo-optic switchs as fast as 1ms were fabricated with an excess insertion loss of 0.5 dB in the “switching state” and 1.5dB in the “non-switching state”. Reconfigurability of the true-time delay line was demonstrated through accurate time delay measurement.
Highly Enantioselective Synthesis of 2H‐1‐Benzothiopyrans by a Catalytic Domino Reaction. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An Experimental Study on Thrust Characteristics Depending on Wing Shape and Structure of Bird-like Flapping Machine (2019)

Many researches have tried to imitate the flight of birds, but there are not many successful non-running takeoffs. In this study, in order to achieve the non-running takeoff, we prototype several kinds of wings that have different shape and structure. The flapping experiments are carried out and the forces are measured and evaluated. The appropriate wing was clarified.
Single-chip, widely-tunable 10 Gbit/s photocurrent-driven wavelength converter incorporating a monolithically integrated laser transmitter and optical receiver (2006)

A single-chip photocurrent-driven wavelength converter operating at 10 Gbit/s is presented. The device consists of a monolithically integrated widely tunable transmitter and an optical receiver. The transmitter consists of a sampled grating DBR laser, electroabsorption modulator and semiconductor optical amplifier (SOA). The optical receiver includes a quantum-well pin photodetector and a set of two SOA preamplifiers. Bit error rate measurements at 10 Gbit/s with a 231−1 PRBS showed less than 1 dB of power penalty for conversion between 1550 nm and output wavelengths ranging from 1531 to 1563 nm.
ChemInform Abstract: Synthesis and Muscarinic Activities of 1,2,4‐Thiadiazoles. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.