gebhart/patrepeval huggingface dataset:
Prediction of Lost Circulation Zones using Support Vector Machine and Radial Basis Function (2020)

Drilling deep and high-pressure high-temperature wells have many challenges and problems. One of the most severe, costly and time-consuming problem in the drilling operation is the loss of circulation. The drilling fluid accounts for 25-40% of the total cost of the drilling operation. Any loss of the drilling fluid will increase the total cost of the drilling operation. Uncontrolled lost circulation of the drilling fluid can result in dangerous well control problems and in some cases the loss of the well. In order to avoid loss circulation, many methods were introduced to identify the zones of losses. However, some of these methods are difficult to be applied due to financial issues and lack of technology and the other methods are not accurate in the prediction of the thief zones. The objective of this paper is to predict the lost circulation zones using two different techniques of artificial intelligence (AI). More than 5000 real field data from two wells that contain the real-time surface drilling parameters was used to predict the zones of circulation loss using radial basis function (RBF) and support vector machine (SVM). Six surface drilling parameters were used as an input. The data of the well (A) was divided into training and testing to build the two AI models and then unseen well (B) was used to validate the ability of AI models to predict the zones of lost circulation. The obtained results showed that the two models of AI were able to predict the zones of circulation loss in well (A) with high accuracy in terms of correlation coefficient (R), root mean squared error (RMSE) and confusion matrix. RBF predicted the losses zones with excellent precision of R = 0.981 and RMSE = 0.088. SVM also achieved higher accuracy with a correlation coefficient of 0.997 and root mean squared error of 0.038. Moreover, the RBF model was able to predict the losses zones in the unseen well (B) that was used as a validation for the ability of the AI models with a correlation coefficient of 0.909 and root mean squared error of 1.686.
Coupling Capillary Zone Electrophoresis with Electron Transfer Dissociation and Activated Ion Electron Transfer Dissociation for Top-Down Proteomics (2015)

Top-down proteomics offers the potential for full protein characterization, but many challenges remain for this approach, including efficient protein separations and effective fragmentation of intact proteins. Capillary zone electrophoresis (CZE) has shown great potential for separation of intact proteins, especially for differentially modified proteoforms of the same gene product. To date, however, CZE has been used only with collision-based fragmentation methods. Here we report the first implementation of electron transfer dissociation (ETD) with online CZE separations for top-down proteomics, analyzing a mixture of four standard proteins and a complex protein mixture from the Mycobacterium marinum bacterial secretome. Using a multipurpose dissociation cell on an Orbitrap Elite system, we demonstrate that CZE is fully compatible with ETD as well as higher energy collisional dissociation (HCD), and that the two complementary fragmentation methods can be used in tandem on the electrophoretic time scale for improved protein characterization. Furthermore, we show that activated ion electron transfer dissociation (AI-ETD), a recently introduced method for enhanced ETD fragmentation, provides useful performance with CZE separations to greatly increase protein characterization. When combined with HCD, AI-ETD improved the protein sequence coverage by more than 200% for proteins from both standard and complex mixtures, highlighting the benefits electron-driven dissociation methods can add to CZE separations.
Modulation of Cannabinoid Receptor Interacting Protein 1a (CRIP1a) Expression Using Adeno‐Associated Virus and Effects on Striatal Neuropharmacology and Neuronal Cells in Culture (2010)

CB1 cannabinoid receptors and the D2 dopamine receptors are both GPCRs that associate with interacting proteins (CRIP1a and DRIP) that bind to the C‐terminus of the receptor. The DRIP neuronal calcium sensor‐1 is involved in Ca2+ mediated regulation of the D2 receptor, whereas the recently discovered cannabinoid receptor interacting protein (CRIP1a), has been shown to suppress the tonic inhibition of voltage‐gated Ca2+ channels induced by CB1 (Niehaus et al., 2007). Therefore, CRIP1a may provide a new avenue for modulation of the endocannabinoid system. AAV that contain transgenes to express shRNA designed to knock down CB1, D2R, or CRIP1a were created and injected via stereotaxically. Striata from AAV‐D2R and AAV‐CB1 shRNA‐treated rats displayed a significant reduction in D2 and CB1 mRNA levels, respectively. The AAV overexpressing CRIP1a virus increased CRIP1a mRNA levels without altering CB1 levels. However, significant reductions occurred in levels of preprodynorphin(Pdyn) and preproenkephalin‐1(Penk‐1). In vitro, N18TG2 stably transfected with CRIP1a‐pcDNA3.1 displayed increased levels of CRIP1a, Pdyn, and delta opioid receptor mRNA levels without effecting CB1 levels. Additionally, CRIP1a overexpressers had a significant reduction in CB1 mediated phosphorylation of ERK during Rimonabant‐sensitive basal conditions. However, CB1 agonist mediated effects on maximum ERK phosphorylation were unaltered in CRIP1a overexpressors. These studies provide both in vivo and in vitro insight into the mechanisms involved in CRIP1a modulation of CB1 receptors.
Suitability of bench scale bioreactor system for shoot biomass production and bacoside biosynthesis from Bacopa monnieri (L.) (2019)

According to folklore, <i>Bacopa monnieri</i> commonly called as Brahmi is known for its cognitive enhancing properties. The plant is found abundantly in wetlands but the drug content (bacosides) is very low (0.2%), therefore, alternative biotechnological protocols are highly needed to supplement the constant source of this valuable plant material which produces stable amounts of bacosides. The present study was conducted to explore the application of different culture systems for cultivation of shoot biomass and maximization of biologically active bacoside biosynthesis in this medicinally important plant. Shoot cultures of Bacopa were cultivated in two different modified benchtop bioreactors: glass bottle bioreactor and balloon type bubble bioreactor and compared with those grown in traditional Erlenmeyer agitated flask. The shoots cultivated in the balloon type bubble bioreactor system showed excellent growth (growth index 796.47 ± 17.27 fresh weight and 395.55 ± 7.55 dry weight) as compared to glass bottle bioreactor system (growth index 488.17 ± 14.4 fresh weight and 327.79 ± 6.64 dry weight) and agitated flask (growth index 363.43 ± 11 fresh weight and 304.22 ± 6.76 dry weight). Furthermore, bacosides produced by shoot cultures cultivated in the balloon type bubble bioreactor (321.95 ± 17.14 mg/L) and glass bottle bioreactor (180.18 ± 6.25 mg/L) configurations were ∼2.78 fold and ∼1.55 fold higher than that recorded in agitated flask cultures (115.7 ± 3.84 mg/L). The balloon type bubble bioreactor system was found to be advantageous for enhancing <i>B. monnieri</i> shoot biomass and bacoside biosynthesis along with ensuring a successful protocol for continuous supply.
Core Cross-Linked Multiarm Star Polymers with Aggregation-Induced Emission and Temperature Responsive Fluorescence Characteristics (2017)

Aggregation-induced emission (AIE) active core cross-linked multiarm star polymers, carrying polystyrene (PS), polyethylene (PE), or polyethylene-b-polycaprolactone (PE-b-PCL) arms, have been synthesized through an “arm-first” strategy, by atom transfer radical copolymerization (ATRP) of a double styrene-functionalized tetraphenylethene (TPE-2St) used as a cross-linker with linear arm precursors possessing terminal ATRP initiating moieties. Polyethylene macroinitiator (PE–Br) was prepared via the polyhomologation of dimethylsulfoxonium methylide with triethylborane followed by oxidation/hydrolysis and esterification of the produced PE–OH with 2-bromoisobutyryl bromide; polyethylene-block-poly(ε-caprolactone) diblock macroinitiator was derived by combining polyhomologation with ring-opening polymerization (ROP). All synthesized star polymers showed AIE-behavior either in solution or in bulk. At high concentration in good solvents (e.g., THF, or toluene) they exhibited low photoluminescence (PL) intensity due to the inner filter effect. In sharp contrast to the small molecule TPE-2St, the star polymers were highly emissive in dilute THF solutions. This can be attributed to the cross-linked structure of poly(TPE-2St) core which restricts the intramolecular rotation and thus induces emission. In addition, the PL intensity of PE star polymers in THF(solvent)/n-hexane(nonsolvent) mixtures, due to their nearly spherical shape, increased when the temperature decreased from 55 to 5 °C with a linear response in the range 40–5 °C.
Training Winner-Take-All Simultaneous Recurrent Neural Networks (2007)

The winner-take-all (WTA) network is useful in database management, very large scale integration (VLSI) design, and digital processing. The synthesis procedure of WTA on single-layer fully connected architecture with sigmoid transfer function is still not fully explored. We discuss the use of simultaneous recurrent networks (SRNs) trained by Kalman filter algorithms for the task of finding the maximum among N numbers. The simulation demonstrates the effectiveness of our training approach under conditions of a shared-weight SRN architecture. A more general SRN also succeeds in solving a real classification application on car engine data.
Northwest Trajectory Analysis Capability: A Platform for Enhancing Computational Biophysics Analysis (2008)

Abstract- As computational resources continue to increase, the ability of computational simulations to effectively complement, and in some cases replace, experimentation in scientific exploration also increases. Today, large-scale simulations are recognized as an effective tool for scientific exploration in many disciplines including chemistry and biology. A natural side effect of this trend has been the need for an increasingly complex analytical environment. In this paper, we describe Northwest Trajectory Analysis Capability (NTRAC), an analytical software suite developed to enhance the efficiency of computational biophysics analyses. Our strategy is to layer higher-level services and introduce improved tools within the user’s familiar environment without preventing researchers from using traditional tools and methods. Our desire is to share these experiences to serve as an example for effectively analyzing data intensive large scale simulation data.
Detection of Financial Opportunities in Micro-Blogging Data With a Stacked Classification System (2020)

Micro-blogging sources such as the Twitter social network provide valuable real-time data for market prediction models. Investors' opinions in this network follow the fluctuations of the stock markets and often include educated speculations on market opportunities that may have impact on the actions of other investors. In view of this, we propose a novel system to detect positive predictions in tweets, a type of financial emotions which we term “opportunities” that are akin to “anticipation” in Plutchik's theory. Specifically, we seek a high detection precision to present a financial operator a substantial amount of such tweets while differentiating them from the rest of financial emotions in our system. We achieve it with a three-layer stacked Machine Learning classification system with sophisticated features that result from applying Natural Language Processing techniques to extract valuable linguistic information. Experimental results on a dataset that has been manually annotated with financial emotion and ticker occurrence tags demonstrate that our system yields satisfactory and competitive performance in financial opportunity detection, with precision values up to 83%. This promising outcome endorses the usability of our system to support investors' decision making.
Wavelength-Dependent Tip-Enhanced Laser Ablation of Organic Dyes (2019)

The wavelength dependence of atomic force microscope apertureless tip-enhanced laser ablation was studied using a series of organic dyes to assess the effect of surface optical absorption. An optical parametric oscillator laser with a tunable wavelength range of 410–2100 nm was used to irradiate a gold-coated atomic force microscope tip which was held 15 nm above the surface of a dye thin film vibrating in tapping mode to generate tip-enhanced laser ablation. Crater formation was investigated for rhodamine B, methylene blue, and IR 797 dye thin films which have absorption maxima near 550, 650, and 700 nm, respectively. Crater formation was not observed for wavelengths greater than 700 nm for any of the dyes. Below 700 nm, the crater size was greatest near 500 nm for all dyes and decreased from 500 to 700 nm, and no ablation was observed at longer wavelengths. The crater size did not correlate with the solution or thin film optical absorption of the dyes. The mechanism for tip-enhanced laser ablation is postulated to be either ballistic ejection of gold atoms or direct heat transfer from the tip to the surface.
Information-theoretic Performance of TR-MRC Receiver in Frequency-Selective Massive MU-MIMO Systems impaired by CFO (2015)

In this paper we study the impact of carrier frequency offset (CFO) impairment on massive multi-user (MU) multiple-input multiple-output (MIMO) system in frequency-selective fading channel. Our study reveals that with CFO estimation and compensation at the base station (BS), a time-reversed maximum ratio combining (TR-MRC) receiver can achieve an $\mathcal{O}(\sqrt{M})$ array gain, where $M$ is the number of BS antennas. Further study of the information rate expression reveals that the increase in the required per-user transmit power (to achieve a desired per-user information rate) with increasing number of channel taps ($L$) is insignificant when $L$ is sufficiently small (i.e. $L\ll$ CFO estimation pilot sequence length divided by the number of user terminals).
Molecular imaging: the future of modern medicine. (2008)

The second Industry/Expert Molecular Imaging Summit, ‘‘Molecular Imaging: The Future of Modern Medicine,’’ was held February 17–19 in Newport Beach, CA. Hosted by the SNM Molecular Imaging Center of Excellence (MICoE), the meeting provided an opportunity for leaders from academia, industry, government, and regulatory agencies to come together both formally and informally to identify and discuss issues crucial to the advancement of molecular imaging along the continuum from discovery to beneficial clinical applications.
Immunological Efficacy of Pneumococcal Vaccination Including the 13-Valent Pneumococcal Conjugate Vaccine in Adult Patients With Sickle Cell Disease: Results of the Randomized DREVAC Controlled Trial (2023)

A PCV13/PPSV23 regimen improved the breadth and magnitude of antibody responses against a large range of pneumococcal serotypes in adults with SCD. The sustainability of the immune response requires recall strategies.Clinical Trial Registration: NCT02274415.
Batch transfer of microstructures using flip-chip solder bonding (1999)

This paper describes a novel method for transfer and assembly of microstructures using sacrificial-layer micromachining and flip-chip bonding. The technique is performed at room temperature (cold weld) and at the back end of the process flow and may thus provide a commercially viable alternative to monolithic integration and costly hybrid packages. The transfer is achieved using break-away tethers and by cold welding (compression bonding) electroplated indium solder bumps to electroplated copper pads. Both high-aspect-ratio MEMS devices as well as surface-micromachined devices have been successfully transferred using this method with no observable misalignment between moving and stationary parts. The maximum tensile and shear stress the solder bond can withstand before failure is measured to be 11/spl plusmn/3 MPa and 9/spl plusmn/1 MPa, respectively. The contact resistance is measured to be of the order of 1.5 m/spl Omega/ for a 65 /spl mu/m/spl times/65 /spl mu/m/spl times/4-/spl mu/m indium bump.
Going to the dogs (2014)

Computer-mediated interaction for working dogs is an important new domain for interaction research. In domestic settings, touchscreens could provide a way for dogs to communicate critical information to humans. In this paper we explore how a dog might interact with a touchscreen interface. We observe dogs' touchscreen interactions and record difficulties against what is expected of humans' touchscreen interactions. We also solve hardware issues through screen adaptations and projection styles to make a touchscreen usable for a canine's nose touch interactions. We also compare our canine touch data to humans' touch data on the same system. Our goal is to understand the affordances needed to make touchscreen interfaces usable for canines and help the future design of touchscreen interfaces for assistive dogs in the home.
Tumour‐Host Interactions in Vivo (1983)

We have earlier shown that coculture of macrophages and cells from a methylcholanthiene‐induced sarcoma (MCI M‐AA) in vitro resulted in macrophage activation and production of type II (gamma) interferon. When ascites fluid from the MCIM‐AA sarcoma (shown previously to activate macrophages in vitro) was added to spleen cell populations from semisyngeneic C 3 D 2 mice in vitro. NK activity was markedly enhanced. After intraperitoneal injection of MCI M‐AA cells or ascites fluid, 4‐ to 12‐fold increased NK cell activity with a peak at 3–5 days could be measured in the spleen cell population and in the non‐adherent peritoneal exudate cell population. The mice injected with tumour cells or ascites fluid developed a pronounced splenomegaly, and maximum spleen size coincided with peak NK activity. Injection of tumour cells or tumour ascites fluid resulted in marked changes in the T‐cell, B‐cell, macrophage, and ‘null’ cell content of ihe peritoneal exudate.
A case for internal migration policy in India. (1996)

Migration helps to minimize regional, socioeconomic, and cultural disparities, and is considered to be an integral component of the development process. Migration helps to diffuse development, technology, and innovations from more developed areas or cities to rural or less developed areas. Little attention, however, has been paid to migration policy in India. Most studies on migration in India either describe the patterns of migration or analyze reasons for the moves. This paper discusses why migration takes place, what are the consequences of migration, whether India has a migration policy, whether India needs a migration policy, and what type of policy is required. The development and entrenchment of urban slums in India is related to the country's lack of migration policy. A two-pronged policy on migration is thus proposed which would ensure employment opportunities and an improved standard of living in rural areas, while taking into account the planning of cities and city surroundings. Rural areas and small towns need to be provided with more employment opportunities, financial and technological support to process raw materials, infrastructure for agricultural service centers, better education and other facilities to improve local living standards, and the diffusion of industries from big cities to district headquarters and medium-size towns. Commensurate efforts should be made in urban centers to prevent the future development of slums.
Theoretical studies of wave propagation in multilayered piezoelectric media (1993)

The purpose of this paper is to extend the analysis of a single plate or substrate to the case of a multilayered medium. Due to the requiring of higher operating frequency, lower attenuation, and stronger piezoelectricity, layered structure becomes necessary. This technique is rapidly applied in the field of nondestructive evaluation and testing (NDE/T). Recently, a new feature of applying the piezoelectric effect for remote sensing, actuating, and vibration controlling came under study and development in aerospace and automative industries.
Orientation of embedded Y 2 BaCuO 5 particles within the YBa 2 Cu 3 O x matrix in melt‐textured YBCO superconductors (2005)

The cover picture of this issue of physica status solidi (c) has been taken from the article [1].
Encoding Complexity Analysis and Reduction for a Practically-Oriented VVC Encoder Implementation (2021)

The latest international Versatile Video Coding (VVC) standard was finalized in July 2020 by the Joint Video Experts Team (JVET) from ITU-T and ISO/IEC. Compared to the High Efficiency Video Coding (HEVC) standard, VVC offers up to 50% of bitrate savings. However, the encoder runtime of the reference software increases tenfold compared to the HEVC equivalent. This paper shows that VVC coding tools which do not consume much of the reference encoder time can have prohibitive computational cost for practical encoders, such as VVenC. VVenC is an optimized open-source real-world implementation with high relevance for practical applications. After analyzing the encoding tools in VTM and VVenC, Symmetric Motion Vector Difference (SMVD) was identified as one of the tools whose efficiency-complexity trade-off may be unfavorable for practical applications. For that reason, two complexity reduction methods for the SMVD search are proposed in this paper. The experimental evaluation on VVenC encoder at an optimized operation point confirms the SMVD encoding runtime reduction by over 72%, with minimal impact on the encoding efficiency.
NVMcached (2016)

As byte-addressable, high-density, and non-volatile memory (NVM) is around the corner to be equipped alongside the DRAM memory, issues on enabling the important key-value cache services, such as memcached, on the new storage medium must be addressed. While NVM allows data in a KV cache to survive power outage and system crash, in practice their integrity and accessibility depend on data consistency enforced during writes to NVM. Though techniques for enforcing the consistency, such as journaling, COW, or checkpointing, are available, they are often too expensive by frequently using CPU cache flushes to ensure crash consistency, leading to (much) reduced performance and excessively compromised NVM's lifetime.