MP68-01 SEMEN QUALITY, INFERTILITY, AND MORTALITY IN THE UNITED STATES (2014)

You have accessJournal of UrologyInfertility: Evaluation1 Apr 2014MP68-01 SEMEN QUALITY, INFERTILITY, AND MORTALITY IN THE UNITED STATES Michael Eisenberg, Shufeng Li, Barry Behr, Mark Cullen, Deron Galusha, Dolores Lamb, and Larry Lipshultz Michael EisenbergMichael Eisenberg More articles by this author , Shufeng LiShufeng Li More articles by this author , Barry BehrBarry Behr More articles by this author , Mark CullenMark Cullen More articles by this author , Deron GalushaDeron Galusha More articles by this author , Dolores LambDolores Lamb More articles by this author , and Larry LipshultzLarry Lipshultz More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.2180AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Aberrations in reproductive fitness may be a harbinger of medical diseases in men. As such, diminished semen production may indicate men at risk for poor health outcomes. We sought to determine if impaired semen parameters were associated with mortality in the years after an infertility evaluation. METHODS Utilizing a multi-center retrospective cohort, semen databases from fertility clinics in Texas and California were queried. A total of 11,935 men evaluated for infertility from 1989 to 2011 were identified. Men were stratified based on abnormal semen parameters as determined by the WHO 5th edition criteria. Mortality was determined by data linkage to the National Death Index and Social Security Death Index. The mortality rate was compared to an age-matched sample from men in the general population. We also analyzed the risk of death in infertile men using a Cox regression models based on semen parameters. RESULTS Compared to the general population, men evaluated for infertility had a lower risk of death with 69 deaths observed compared with 176.7 expected (SMR 0.39, 95% CI 0.30-0.49). When stratified by semen parameters, however, men with impaired semen parameters (i.e. male factor infertility) had significantly higher mortality rates compared with men with normal parameters (i.e. no male factor infertility). Low semen volume, sperm concentration, sperm motility, total sperm count, and total motile sperm count were associated with higher risk of death. In contrast, abnormal sperm morphology was not associated with mortality. While adjusting for current health status attenuated the association between semen parameters and mortality, men with two or more abnormal semen parameters still 2.3 fold higher risk of death compared to men with normal semen (95% CI 1.12-4.65). CONCLUSIONS Men with impaired semen parameters have an increased mortality rate in the years following an infertility evaluation suggesting additional follow up of these men is warranted after reproductive efforts have ceased. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e798 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Michael Eisenberg More articles by this author Shufeng Li More articles by this author Barry Behr More articles by this author Mark Cullen More articles by this author Deron Galusha More articles by this author Dolores Lamb More articles by this author Larry Lipshultz More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...