gebhart/patrepeval huggingface dataset:
Origin of the Damping Effect on the Stereoselectivity of Electrophile Capture Caused by the Remote Double Bond in Lithium Tricyclo[5.2.1.02,6]deca-3,5,8-trienide. Structure of This Cyclopentadienide in Tetrahydrofuran Solution (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrigin of the Damping Effect on the Stereoselectivity of Electrophile Capture Caused by the Remote Double Bond in Lithium Tricyclo[5.2.1.02,6]deca-3,5,8-trienide. Structure of This Cyclopentadienide in Tetrahydrofuran SolutionLeo A. Paquette, Mark R. Sivik, Walter Bauer, and P. v. R. SchleyerCite this: Organometallics 1994, 13, 12, 4919–4927Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/om00024a039https://doi.org/10.1021/om00024a039research-articleACS PublicationsRequest reuse permissionsArticle Views66Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Interruption of Antiretroviral Therapy Initiated during Primary HIV-1 Infection: Impact of a Therapeutic Vaccination Strategy Combined with Interleukin (IL)-2 Compared with IL-2 Alone in the ANRS 095 Randomized Study (2007)

HIV-specific T cell responses play a critical role in the control of infection. We evaluated the impact of immune-based interventions in patients first treated during primary HIV-1 infection (PHI). Forty-three patients were randomized within three groups, to receive either interleukin-2 (IL-2 group), or boosts of ALVAC-HIV (vCP1433) and LIPO-6T followed by interleukin-2 (Vac-IL2 group), compared with no immune intervention (control group), and were monitored for T cell responses. Impact of strategies on viral replication was subsequently assessed during long-term treatment interruption. HIV-specific CD4(+) T cell responses did not change during the study period in immunized patients relative to controls, and vaccination had only a transient effect on interferon-gamma-producing CD8 responses. Viral rebound after treatment interruption was similar in immunized patients and controls. Forty percent of patients had HIV RNA values <10,000 copies/ml 12 weeks after interruption. The cumulative time off treatment represented almost half the total follow-up period. Immunological and virological status during PHI and HIV DNA load at interruption were predictive of the level of viral rebound after treatment interruption, whereas HIV RNA level during PHI and HIV DNA level at interruption were predictive of the time off treatment. Treatment interruption is safe in patients treated early after primary HIV infection. On the basis of this pilot study, HIV immunizations and interleukin-2 appear to have no supplementary benefit.
Phenotypical and Functional Characterization of Clinical Grade Dendritic Cells (2002)

Dendritic cells (DC) are the professional antigen presenting cells of the immune system. Therefore, several clinical studies have been initiated in which tumor antigen-loaded DC are used as a vaccine to boost an immune response against malignant tumors in patients with cancer. A prerequisite for DC used in these vaccination studies is not only that they are grown under "Good Manufacturing Practice" but equally important that they retain their functional properties. In an extensive study, various conditions were tested to optimize the maturation and yield of DC grown for clinical use. DC grown in XVIVO-15 medium supplemented with 5% HS yielded the best results, morphologically and phenotypically. Mature DC expressed significant amounts of mature DC markers (CD83) and the costimulatory molecules CD80 and CD86. It was shown that mature and immature DC can be frozen and retain their phenotype and function after thawing. These clinical grade DC secreted high levels of the chemokines dendritic cell chemokine 1 (DC-CK1), interleukin-8 (IL-8), macrophage-derived chemokine (MDC), and thymus and activation-regulated chemokine (TARC). This implicates that these DC can attract naïve T and B cells as well as natural killer cells and memory T cells. Finally, to test their migratory capacity in vivo, (111)In-labeled DC were injected into tumor-free lymph nodes of patients with melanoma. Autoradiographic analysis of the dissected lymph nodes indicated that these DC could migrate into the T cell area of adjacent lymph nodes. In conclusion, a culture procedure was established to generate large numbers of monocyte-derived immature and mature DC that retain their morphologic, phenotypic, and functional characteristics in vitro and can be visualized in situ.
Exceptional inheritance of plastids via pollen in Nicotiana sylvestris with no detectable paternal mitochondrial DNA in the progeny (2012)

Plastids and mitochondria, the DNA-containing cytoplasmic organelles, are maternally inherited in the majority of angiosperm species. Even in plants with strict maternal inheritance, exceptional paternal transmission of plastids has been observed. Our objective was to detect rare leakage of plastids via pollen in Nicotiana sylvestris and to determine if pollen transmission of plastids results in co-transmission of paternal mitochondria. As father plants, we used N. sylvestris plants with transgenic, selectable plastids and wild-type mitochondria. As mother plants, we used N. sylvestris plants with Nicotiana undulata cytoplasm, including the CMS-92 mitochondria that cause cytoplasmic male sterility (CMS) by homeotic transformation of the stamens. We report here exceptional paternal plastid DNA in approximately 0.002% of N. sylvestris seedlings. However, we did not detect paternal mitochondrial DNA in any of the six plastid-transmission lines, suggesting independent transmission of the cytoplasmic organelles via pollen. When we used fertile N. sylvestris as mothers, we obtained eight fertile plastid transmission lines, which did not transmit their plastids via pollen at higher frequencies than their fathers. We discuss the implications for transgene containment and plant evolutionary histories inferred from cytoplasmic phylogenies.
Operating behavior and design of the half-cycle discontinuous-conduction-mode series-resonant-converter with small DC link capacitors (2013)

The series-resonant-converter operated in half-cycle discontinuous-conduction-mode is a realization option for bidirectional isolated DC/DC converter modules, which are key components of modern solid state transformer (SST) concepts, among other applications. In SSTs the DC/DC converters are interfacing the input and output inverter stages via DC links. For reasons of costs as well as possible application-specific restrictions on weight and volume it is beneficial to use as small DC link capacitors as possible. However, when the resonant capacitance is higher than about 10% of the DC link capacitances, the deviation of the resonant current waveform from the sinusoidal shape becomes significant and the half-cycle duration is altered from values calculated using common approaches. Here, a comprehensive discussion of this case is given and design guidelines for the choice of the resonant capacitor are derived. The importance of the effect is illustrated by applying these to a complete design example.
The Absolute Configuration of Belactin A, a β-Lactone-Containing Serine Carboxypeptidase Inhibitor: Importance of the β-Lactone Structure for Serine Carboxypeptidase Inhibition (1999)

The absolute configuration of belactin A, a beta-lactone-containing serine carboxypeptidase inhibitor was studied by a crystal X-ray diffraction analysis and its absolute structure was determined to be (2R,3S)-2-¿(3S)-3-[(2-amino-5-chlorophenyl)carboxamido]-1,1-dimethyl-2-o xobutyl¿-3-methyl-4-oxooxetane. The importance of the beta-lactone structure for inhibitory activity was found by preparing several derivatives of belactin A.
Plant extracts: from encapsulation to application (2016)

Major obstacles associated with the use of plant extracts for clinical applications include their complex composition, toxicity risks and extract instability. It is observed that encapsulation can be successfully used to decrease plant extracts toxicity, to provide targeted drug delivery and to solve stability related problems.
Homologous Boosting with Adenoviral Serotype 5 HIV Vaccine (rAd5) Vector Can Boost Antibody Responses despite Preexisting Vector-Specific Immunity in a Randomized Phase I Clinical Trial (2014)

Clinicaltrials.gov NCT00709605 NCT00709605.
<title>Effect of wavelength and dye selection on biosensor response</title> (1995)

The availability of low cost laser diodes and new fluorescent dyes has made portable biosensors a reality. Previously, we have examined the variation in the fluorescent signal generated in an antigen-antibody reaction when the antigen is labeled with dyes exciting at different wavelengths. In this study, we looked at the effect of changing dyes and wavelengths on a sandwich immunoassay for the F1 antigen from Yersinia pestis, the etiologic agent of plaque. The F1 immunoassay has previously been demonstrated to work in serum, plasma, and even whole blood, when performed using a fiber optic biosensor. In this study, we demonstrated that changing to cyanine dyes enhanced the sensitivity of the detection without altering the immunochemistry of the assay.
Analysis of guided resonances in photonic crystal slabs (2002)

We present a three-dimensional analysis of guided resonances in photonic crystal slab structures that leads to a new understanding of the complex spectral properties of such systems. Specifically, we calculate the dispersion diagrams, the modal patterns, and transmission and reflection spectra of these resonances. From these calculations, a key observation emerges involving the presence of two temporal pathways for transmission and reflection processes. Using this insight, we introduce a general physical model that explains the essential features of complex spectral properties. Finally, we show that the quality factors of these resonances are strongly influenced by the symmetry of the modes and the strength of the index modulation.
Abstract 3974: A preclinical study for miR181b as therapeutic in Eu-TCL1FL-tg mouse model for CLL (2015)

Abstract Chronic lymphocytic leukemia (CLL) is a malignancy of B cells with immunophenotype of memory cells. Downstream pathways to BCR, like NFkB, AKT and ERK, and anti-apoptotic proteins such as Bcl2 and Mcl1, are thought to contribute to expansion and survival of the malignant cells. CLL patients show different clinical course: tumor clones having no V-gene mutations, many CD38+ or ZAP-70+ B cells, chromosome 11q deletion and high expression of TCL1, had an aggressive, usually fatal course, whereas patients with mutated clones, few CD38+ or ZAP-70+ B cells and low TCL1 expression, had an indolent course. Recent studies identified a microRNA signature associated with prognosis and progression in B-CLL. Particularly, miR181b is down-regulated in aggressive forms of CLL and its expression is inversely correlated to Tcl1 levels. An increasing number of studies are considering microRNAs as potentially useful therapeutic agents. Given that MCL-1, BCL-2 and TCL1 are proved targets for miR181b, that Akt activation is enhanced by Tcl1 and a crosstalk between Akt and ERK or NFkB exists, we performed a preclinical evaluation of miR181b therapeutic efficacy in a mouse model of CLL, the Eu-TCL1 transgenic mouse, previously generated by us. In vitro enforced expression of miR-181b mimics induced a significant apoptotic effect in human B-cell line EHEB, as well as in mouse Eμ-TCL1 leukemic splenocytes. Molecular analyses revealed that miR-181b not only affected the expression of Tcl1, Bcl2 and Mcl1 anti-apoptotic proteins, but also increased the expression level of the NFkB inhibitor protein IkB-alpha and reduced the phosphorylation levels of Akt and Erk1/2. Notably, an anti-TCL1 siRNA could similarly down-modulate Tcl1 but exhibited a reduced or absent activity on other relevant proteins, as well as a reduced effect on cell apoptosis and viability. In vivo studies indicated a significant capability of miR-181b in reducing leukemic cells expansion and increasing survival of treated mice. These data indicate that miR-181b exerts a broad range of actions, affecting proliferative, survival and apoptotic pathways, both in mice and human, and can potentially be employed to reduce expansion of B-CLL leukemic cells. Citation Format: Antonella Bresin, Elisa Callegari, Lucilla D'Abundo, Caterina Cattani, Cristian Bassi, Barbara Zagatti, Maria Grazia Narducci, Elisabetta Caprini, Yuri Pekarsky, Carlo Maria Croce, Silvia Sabbioni, Massimo Negrini, Giandomenico Russo. A preclinical study for miR181b as therapeutic in Eu-TCL1FL-tg mouse model for CLL. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3974. doi:10.1158/1538-7445.AM2015-3974
Aromatase inhibition plus/minus Src inhibitor saracatinib (AZD0530) in advanced breast cancer therapy (ARISTACAT): a randomised phase II study (2023)

Saracatinib did not improve outcomes in post-menopausal women with metastatic breast cancer. There was no observed beneficial effect on bone metastases. CRUKE/11/023, ISRCTN23804370.
Potent and specific sialyltransferase inhibitors: imino-linked 5a′-carbadisaccharides (2003)

Methyl 5a'-carba-beta-lactoside, imino-linked, has been shown to possess potent and specific inhibitory activity (IC50 = 185 microM) toward rat recombinant alpha2,3-sialyltransferase.
Up‐regulation of HIV coreceptor CXCR4 expression in human T lymphocytes is mediated in part by a cAMP‐responsive element (2002)

The chemokine and HIV receptor CXCR4 has been shown to play a role in chemotaxis and HIV-1 entry into T cells. Dibutyryl cAMP (DcAMP), an analog of cAMP, has been shown to increase CXCR4 cell surface expression and HIV-1 infectivity, but the molecular mechanism(s) responsible is unknown. Here we show that DcAMP treatment of purified human T lymphocytes increased transcription of CXCR4 mRNA as well as cell surface and intracellular CXCR4 protein expression. DcAMP-mediated stimulation of human PBL increased T-trophic HIV-1 (X4) fusion and viral replication as measured by syncytia formation and p24 levels, respectively. To determine the region(s) of the CXCR4 promoter required for cAMP responsiveness, truncations and point mutations of the CXCR4 promoter (nucleotides -1098 to +59) fused to luciferase were constructed and transiently transfected into human PBL. Deletional analysis demonstrated that the -1098 to -93 region of the CXCR4 promoter construct could be eliminated; the residual (-93 to +59) promoter retained cAMP responsiveness. Site-directed mutagenesis of a putative cAMP-responsive element (CRE) in the 5' UTR (+41 to +49) significantly and specifically attenuated the ability of DcAMP to drive the minimal CXCR4 promoter. Electrophoretic mobility shift assays demonstrated the formation of a complex between the CREB transcription factor and the putative CXCR4 CRE site. Our findings demonstrate a CRE element within the CXCR4 promoter that regulates CXCR4 transcription in response to changes in cAMP signaling. The cAMP-dependent up-regulation of CXCR4 mRNA results in increased CXCR4 intracellular and cell surface protein expression as well as increased HIV infectivity.
Image uniformity improvement for birdcage-like volume coils at 400 MHz using multichannel excitations (2006)

We present a new method to deal with MRI non-uniformities caused by electromagnetic wave interference patterns at 300–400 MHz in lossy dielectrics. The non-uniformities are also known as “dielectric resonance” effects, yielding bright and dark spots at higher frequencies. The proposed method consists of applying a series of multiple cos(nϕ) (n = 1, …) circular current distributions on the birdcage legs in independent MRI experiments. The signals obtained during each experiment are then coalesced into a uniform image using appropriate weighting factors. The level of uniformity is improved by the application of additional cos(nϕ)-birdcage-like channels. © 2006 Wiley Periodicals, Inc. Concepts Magn Reson Part B (Magn Reson Engineering) 29B: 153–160, 2006
Firewall-friendly VoIP secure gateway and VoIP security issues (2003)

IP telephony services using VoIP (Voice over Internet Protocol) technologies have rapidly spread over the last several years. However, interoperation of an IP-PBX (Private Branch eXchange) service and a consumer IP telephony service has not yet been achieved. This is because typical intranets are protected by firewalls and IP telephony protocols are not firewall-friendly-because, among other reasons, they use UDP (User Datagram Protocol)-based protocols. In this paper, we explain the technologies of the VoIP Secure Gateway, which makes IP telephony protocols firewall-friendly and enables an enterprise IP-PBX service to interoperate with a consumer IP telephony service through a firewall. Also, we look at other security problems that need to be solved in order to expand IP telephony services in the future.
Reply to Commentary on “History of Spinal Neurosurgery and Spine Societies” (2021)

See commentary "Commentary on âHistory of Spinal Neurosurgery and Spine Societiesâ" in Volume 18 on page 252.
A phase I trial of intra-lymph-node administration of a novel immunotherapeutic regimen (MKC1106-MT) in patients with advanced melanoma. (2010)

8535 Background: MKC1106-MT is an immunotherapeutic consisting of recombinant plasmid pMEL-TYR containing Melan-A (MEL) and tyrosinase (TYR) antigen fragments and 2 peptide (E-MEL; E-TYR) analogs corresponding to an HLA-A*0201-restricted epitopes from each. Methods: Patients received a prime-boost with a fixed priming of the plasmid (2,400 μ g/dose) via ultrasound guided injections into inguinal or axillary nodes on days 1, 4, 15 and 18 followed by peptide on days 29 and 32; cycles were repeated every 43 days. Either 100 mg/dose or 300 mg/dose of each peptide were given. Patients were HLA*0201+, and had stage IIIB/C or IV melanoma positive for MEL and TYR. Clinical evaluations occurred at baseline and the end of each cycle. Patients without disease progression received up to 8 cycles of treatment. Immune responses using PBMCs were measured days 29 and 39 of each cycle by MHC tetramer and IFN gamma ELISPOT for MEL and TYR epitopes. Results: 18 pts were enrolled: 7 in the low dose and 11 in the high dose peptide cohort. Therapy was well tolerated, with no DLTs. No differences in safety or immune responses were seen between the 2 cohorts. The most frequent treatment-related AEs were: fatigue (grade 1-2), chills (grade 1-2) and brief pain at injected sites (grade 1-2). At 1 year, 4 pts, all with nodal metastases showed ORs (1 CR, 2 PRs and 1 SD by RECIST) and all exhibited high baseline levels of MEL T cells. Among two biopsies of regressing lesions one had a dense infiltration of CD8+ T cells with ∼1% TILs being specific for the MEL epitope targeted by MKC1106-MT. Conclusions: Repeated intra-lymph node administration of MKC1106-MT is feasible, safe, induces objective tumor regression and correlates with baseline immunity to MEL. % tetramer MEL+/total CD8+ at baseline (median; range) No OR OR Detectable 4/14 pts ( 0.25; 0.2-0.31) 4/4 pts (0.2; 0.11-0.23) Low/None detectable 10/14 pts (0.06; 0-0.08) 0/4 pts Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Mannkind Mannkind Mannkind
Alarm YANG Model (2016)

This document describes the Alarm YANG data model for modeling and
reporting standing alarm conditions.
Nonlinear Interactions between the Pumping Kinetics, Fluid Dynamics and Optical Resonator of cw Fluid Flow Lasers. (1983)

Abstract : This research is an integrated theoretical and experimental investigation of the nonlinear interactions which may occur between the chemical kinetics, the fluid dynamics and the unstable resonator of a continuous wave fluid flow laser. The objectives of this grant were to measure the frequency and amplitude of the time dependent pulsations in the power spectral output which have been predicted to occur in cw chemical lasers employing unstable resonators to extract power.
Time to Symptom Resolution in Ulcerative Colitis With Multimatrix Mesalazine Treatment: A Pooled Analysis (2020)

Induction with multimatrix mesalazine provided rapid and prolonged symptom resolution in addition to endoscopic remission at Month 12.
ChemInform Abstract: Iodocyclization of O‐(3‐Cyclohexenyl)thiocarbamidates. An Unexpected Approach to Vicinal cis‐Aminocyclohexenols. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Essential oils purified from Schisandrae semen inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 activation and migration of human aortic smooth muscle cells (2015)

Taken together, these results suggest that SSeo treatment suppresses TNF-α-induced HASMC migration by selectively inhibiting MMP-9 expression, which was associated with suppression of the NF-κB signaling pathway. Taken together, these results suggest that SSeo has putative potential anti-atherosclerotic activity.
Whole Proteome Analysis of Mouse Lymph Nodes in Cutaneous Anthrax (2014)

This study aimed to characterize a soluble proteome of popliteal lymph nodes during lymphadenitis induced by intradermal injection of Bacillus anthracis Sterne spores in mice using tandem LC-MS/MS and reverse-phase protein microarray with antibodies specific to epitopes of phosphorylated proteins. More than 380 proteins were detected in the normal intra-nodal lymph, while the infectious process resulted in the profound changes in the protein abundances and appearance of 297 unique proteins. These proteins belong to an array of processes reflecting response to wounding, inflammation and perturbations of hemostasis, innate immune response, coagulation and fibrinolysis, regulation of body fluid levels and vascular disturbance among others. Comparison of lymph and serum revealed 83 common proteins. Also, using 71 antibodies specific to total and phosphorylated forms of proteins we carried initial characterization of circulating lymph phosphoproteome which brought additional information regarding signaling pathways operating in the lymphatics. The results demonstrate that the proteome of intra-nodal lymph serves as a sensitive sentinel of the processes occurring within the lymph nodes during infection. The acute innate response of the lymph nodes to anthrax is accompanied by cellular damage and inflammation with a large number of up- and down-regulated proteins many of which are distinct from those detected in serum. MS data are available via ProteomeXchange with identifier PXD001342.
mist: Multispectral Image Similarity Transformation (1997)

This document describes work intended to aid in the problem of automatically registering two images of dissimilar type.