gebhart/patrepeval huggingface dataset:
Abstract 1038: Regulation of cyclin A by FoxO3a drives proliferation in anaplastic thyroid carcinoma (2011)

Abstract The Forkhead transcription factor, FoxO3a, is a known suppressor of primary tumor growth and is negatively regulated by growth factors via phosphorylation and mislocalization from the nucleus to the cytoplasm. Here we show for the first time that FoxO3a is nuclear in anaplastic thyroid carcinoma (ATC) and it transcriptionally upregulates cyclin A thereby promoting tumor growth in human ATC cells. Silencing FoxO3a in ATC cell lines leads to down-regulation of cyclin A mRNA and protein while over-expression of FoxO3a leads to upregulation of cyclin A protein. Transient co-transfection of cyclin A promoter linked to luciferase with FoxO3a leads to enhanced luciferase activity, which can be ablated when mutating the FoxO3a site on the cyclin A promoter. This combined data implicates an entirely novel function for FoxO3a in modulating cancer progression by promoting cell cycle progression and tumor growth. ATC is a poorly differentiated carcinoma with average survival upon diagnosis of 3–4 months with 99% lethality, notably the most aggressive and deadliest cancers known. This data also suggest that any therapies under development to inactivate FOXO3a may be effective at blocking tumor expansion. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1038. doi:10.1158/1538-7445.AM2011-1038
Enzymatic Production and Enzymatic-Mass Spectrometric Fingerprinting Analysis of Chitosan Polymers with Different Nonrandom Patterns of Acetylation (2019)

Chitosans, a family of ß-(1,4)-linked, partially N-acetylated polyglucosamines, are considered to be among the most versatile and most promising functional biopolymers. Chemical analysis and bioactivity studies revealed that the functionalities of chitosans strongly depend on the polymers' degree of polymerization and fraction of acetylation. More recently, the pattern of acetylation ( P<sub>A</sub>) has been proposed as another important parameter to influence functionalities of chitosans. We therefore carried out studies on the acetylation pattern of chitosan polymers produced by three recombinant fungal chitin deacetylases (CDAs) originating from different species, namely, Podospora anserina, Puccinia graminis f. sp. tritici, and Pestalotiopsis sp. We analyzed the chitosans by <sup>1</sup>H NMR, <sup>13</sup>C NMR, and SEC-MALS and established new methods for P<sub>A</sub> analysis based on enzymatic mass spectrometric fingerprinting and in silico simulations. Our studies strongly indicate that the different CDAs indeed produce chitosans with different P<sub>A</sub>. Finally, Zimm plot analysis revealed that enzymatically treated polymers differ with respect to their second virial coefficient and radius of gyration indicating an influence of P<sub>A</sub> on polymer-solvent interactions.
Experimental verification of wireless LAN with distributed smart antenna system (D-SAS) in a train environment (2020)

For high-density wireless LAN environment, the interference among overlapped basic service sets (OBSSs) is a serious problem. To address this issue, we have proposed distributed smart antenna system (D-SAS) for wireless LAN, which suppresses the interference among OBSSs and improves the throughput. We have also developed the prototype of wireless LAN access point (AP) with D-SAS and demonstrated the system throughput with stadium environment. In this letter, we evaluate the performance of the developed wireless LAN AP with D-SAS on a train environment and describe that throughput with D-SAS is superior to that with the conventional centralized antennas. It was found that the developed D-SAS AP provides twice system throughput larger than the conventional AP with centralized antennas.
The Na+ ‐motive terminal oxidase activity in an alkalo‐ and halo‐tolerant Bacillus (1989)

An alkalo- and halo-tolerant aerobic microorganism has been isolated which, according to microbiological analysis data and the ribosomal 5S RNA sequence, is a Bacillus similar, but not identical, to B. licheniformis and B. subtilis. The microorganism, called Bacillus FTU, proved to be resistant to the protonophorous uncoupler carbonylcyanide m-chlorophenylhydrazone (CCCP). The fast growth of Bacillus FTU in the presence of CCCP was shown to require a high Na+ concentration in the medium. A procedure was developed to exhaust endogenous respiratory substrates in Bacillus FTU cells so that fast oxygen consumption by the cells was observed only when an exogenous respiratory substrate was added. The exhausted cells were found to oxidize ascorbate in the presence of N,N,N',N'-tetramethyl-p-phenylenediamine (TMPD) in a cyanide-sensitive fashion. The ascorbate oxidation was coupled to the uphill Na+ extrusion which was stimulated by CCCP and a penetrating weak base, diethylamine, as well as by valinomycin with or without diethylamine. Operation of the Bacillus FTU terminal oxidase resulted in the generation of a delta psi which, in the Na+ medium, was slightly decreased by CCCP and strongly decreased by CCCP + diethylamine. In the K+ medium, CCCP discharged delta psi even without diethylamine. Ascorbate oxidation was competent in ATP synthesis which was resistant to CCCP in the Na+ medium and sensitive to CCCP in the K+ medium as if Na+- and H+-coupled oxidative phosphorylations were operative in the Na+ and K+ media, respectively. Inside-out subcellular vesicles of Bacillus FTU were found to be competent in the Na+ uptake supported by oxidation of ascorbate + TMPD or diaminodurene. CCCP or valinomycin + K+ increased the Na+ uptake very strongly. The process was completely inhibited by cyanide or monensin, the former, but not the latter, being inhibitory for respiration. The data obtained indicate that in Bacillus FTU there is not only H+-motive but also Na+-motive terminal oxidase activity.
Measurements ofWγandZγproduction inppcollisions ats=7  TeVwith the ATLAS detector at the LHC (2013)

The integrated and differential fiducial cross sections for the production of a $W$ or $Z$ boson in association with a high-energy photon are measured using $pp$ collisions at $\sqrt{s}=7\text{ }\text{ }\mathrm{TeV}$. The analyses use a data sample with an integrated luminosity of $4.6\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$ collected by the ATLAS detector during the 2011 LHC data-taking period. Events are selected using leptonic decays of the $W$ and $Z$ bosons [$W(e\ensuremath{\nu},\ensuremath{\mu}\ensuremath{\nu})$ and $Z({e}^{+}{e}^{\ensuremath{-}},{\ensuremath{\mu}}^{+}{\ensuremath{\mu}}^{\ensuremath{-}},\ensuremath{\nu}\overline{\ensuremath{\nu}})$] with the requirement of an associated isolated photon. The data are used to test the electroweak sector of the Standard Model and search for evidence for new phenomena. The measurements are used to probe the anomalous $WW\ensuremath{\gamma}$, $ZZ\ensuremath{\gamma}$, and $Z\ensuremath{\gamma}\ensuremath{\gamma}$ triple-gauge-boson couplings and to search for the production of vector resonances decaying to $Z\ensuremath{\gamma}$ and $W\ensuremath{\gamma}$. No deviations from Standard Model predictions are observed and limits are placed on anomalous triple-gauge-boson couplings and on the production of new vector meson resonances.
Outdoor-to-indoor Propagation Characteristics of 1900 MHz Signals in Macro-cellular Environments for GSM and UMTS Systems (2015)

Building penetration loss at 1900 MHz bands in suburban environment is evaluated. The measurements are conducted in real Global System for Mobile Communications (GSM) and Universal Mobile Telecommunications System (UMTS) networks. Four buildings are studied aiming to provide first-order statistics of mobile signal coverage inside buildings. Results show that, on average, no significant signal band dependency has been confirmed. In general, UMTS-1900 MHz signals exhibit slight higher penetration loss values than GSM-1900 MHz signals. Analysis shows that the mean building penetration loss for all measured signals at the ground floor is about 16 dB. The standard deviation of building penetration loss was about 4.5 dB for wideband signals and 2.5 dB for narrowband signals. Results show also that, the average rate of change in building penetration loss with height is 0.95 dB per meter for wideband signals versus 0.65 dB per meter for narrowband signals.
Assessment of the efficacy and side effect profile of morphine and MMP2200, a mixed delta/mu agonist (2009)

We have previously reported on the chemistry and preclinical pharmacology of a series of glycosylated enkephalin analogs. These compounds exhibit high affinity/efficacy at delta and mu opioid receptors (DOR and MOR). The current studies present a more detailed characterization of the pharmacology of MMP2200, a lead glycopeptide that incorporates the disaccharide lactose into the peptide structure. MMP2200 produced dose‐related antinociception in the mouse 55°C tail‐flick assay following a variety of routes of administration. The compound was also effective at reversing thermal hyperalgesia (CFA model) and tactile allodynia (plantar incision) in rats. At equi‐antinociceptive doses MMP2200 produced significantly less stimulation of locomotor activity compared to morphine in mice. MMP2200 produced dose‐related inhibition of gastrointestinal transit and respiration similar to that produced by morphine. In summary, MMP2200 acts as a mixed delta/mu agonist in vivo. This profile may account in part for the potent antinociceptive effects seen in several different rodent models of pain, as well as the decreased propensity to produce locomotor stimulation compared to morphine. For other measures (inhibition of GI transit and respiratory depression), the compound may exert too strong an effect on the MOR to differentiate it from morphine.
Identification of a tumor-specific allo-HLA–restricted γδTCR (2019)

γδT cells are key players in cancer immune surveillance because of their ability to recognize malignant transformed cells, which makes them promising therapeutic tools in the treatment of cancer. However, the biological mechanisms of how γδT-cell receptors (TCRs) interact with their ligands are poorly understood. Within this context, we describe the novel allo-HLA-restricted and CD8α-dependent Vγ5Vδ1TCR. In contrast to the previous assumption of the general allo-HLA reactivity of a minor fraction of γδTCRs, we show that classic anti-HLA-directed, γδTCR-mediated reactivity can selectively act on hematological and solid tumor cells, while not harming healthy tissues in vitro and in vivo. We identified the molecular interface with proximity to the peptide-binding groove of HLA-A*24:02 as the essential determinant for recognition and describe the critical role of CD8 as a coreceptor. We conclude that alloreactive γδT-cell repertoires provide therapeutic opportunities, either within the context of haplotransplantation or as individual γδTCRs for genetic engineering of tumor-reactive T cells.
Applying game theory to analyze attacks and defenses in virtual coordinate systems (2011)

Virtual coordinate systems provide an accurate and efficient service that allows hosts on the Internet to determine latency to arbitrary hosts based on information provided by a subset of participating nodes. Unfortunately, the accuracy of the service can be severely impacted by compromised nodes providing misleading information. We define and use a game theory framework in order to identify the best attack and defense strategies assuming that the attacker is aware of the defense mechanisms. Our approach leverages concepts derived from the Nash equilibrium to model more powerful adversaries. We consider attacks that target the latency estimation (inflation, deflation, oscillation) and defense mechanisms that combine outlier detection with control theory to deter adaptive adversaries. We apply the game theory framework to demonstrate the impact and efficiency of these attack and defense strategies using a well-known virtual coordinate system and real-life Internet data sets.
Molecular mechanisms of cobalt-catalyzed hydrogen evolution (2012)

Several cobalt complexes catalyze the evolution of hydrogen from acidic solutions, both homogeneously and at electrodes. The detailed molecular mechanisms of these transformations remain unresolved, largely owing to the fact that key reactive intermediates have eluded detection. One method of stabilizing reactive intermediates involves minimizing the overall reaction free-energy change. Here, we report a new cobalt(I) complex that reacts with tosylic acid to evolve hydrogen with a driving force of just 30 meV/Co. Protonation of Co(I) produces a transient Co(III)-H complex that was characterized by nuclear magnetic resonance spectroscopy. The Co(III)-H intermediate decays by second-order kinetics with an inverse dependence on acid concentration. Analysis of the kinetics suggests that Co(III)-H produces hydrogen by two competing pathways: a slower homolytic route involving two Co(III)-H species and a dominant heterolytic channel in which a highly reactive Co(II)-H transient is generated by Co(I) reduction of Co(III)-H.
Server-driven progressive image transmission of JPEG 2000 (2007)

Progressive transmission of images is an important functionality for communicating high resolution images over limited bandwidth networks. By encoding the image data in an accessible and hierarchical format, the JPEG 2000 standard supports many types of image progressions, e.g., based on quality, resolution, component and position. This paper considers a progressive transmission scheme in which codestream ordering and transmission decisions are driven entirely by the server, which is useful for classes of applications that employ image analysis at the server and perform streaming based on the results of this analysis. The proposed system aims to minimize signaling overhead and allow for incremental decoding and display with minimal processing delay. It also aims to fully exploit the various styles of progression that are enabled by the JPEG 2000 coding format. The performance of our proposed scheme is reported in terms of signaling overhead, complexity and visual effectiveness.
Surface acoustic waves and Mach stem formation produced by lithotripter shock wave-stone interaction (2021)

Lithotripter shock wave (LSW)-stone interaction may vary significantly due to respiratory motion of the patient. In this work, we have investigated the variations of the LSW-stone interaction and associated stone fracture pattern using photoelastic imaging, phantom experiments, and three-dimensional fluid-solid interaction modeling at different lateral locations in a lithotripter field. In contrast to the T-shaped fracture pattern observed in a disk-shaped stone under symmetric loading, we have observed a gradual transition of the fracture pattern to a tilted L-shape under asymmetric loading. Importantly, our model simulations reveal the generation of surface acoustic waves (SAWs)—a leaky Rayleigh wave on the anterior and a Scholte wave on the posterior surface of the stone. The propagation of SAWs on the stone boundary is accompanied by a progressive transition of the LSW reflection pattern from regular to von Neumann and to weak von Neumann reflection near the glancing incidence and, concomitantly, the development of a Mach stem, swirling around the stone boundary. The maximum tensile stress and stress integral are produced by SAWs on the stone boundary under asymmetric loading, which drive the initiation and extension of surface cracks into the bulk of the stone that has been confirmed by microCT analysis.
Intelligent modeling and optimization of grinding processes (2000)

The objective of this study is to develop and implement a methodology for modeling complex grinding processes and finding optimal process conditions to meet a general class of process requirements. In order to achieve these goals, novel modeling schemes and optimization methods based on fuzzy logic, neural networks, and evolutionary algorithms (EA) are developed. A hierarchical structure which consists of radial basis function networks (RBFN), fuzzy basis function networks (FBFN), and analytical equations is proposed to construct a comprehensive model of the grinding process. Two new algorithms, orthogonal least-squares learning using genetic algorithm (OLSGA) and adaptive least-squares (ALS) algorithm, based on the least-squares method and genetic algorithm (GA), are proposed for autonomous learning and construction of RBFN's and FBFN's, respectively. The first approach taken in this study for optimization of a grinding processes is based on the improved fuzzy rule-based optimization scheme in the generalized intelligent grinding advisory system (GIGAS). Next, a new approach based on model-based optimization scheme is also proposed in order to deal with a more general class of grinding optimization problems. Since grinding optimization can be considered as constrained nonlinear optimization problems with mixed-integer variables and time-varying characteristics, a novel algorithm based on the evolution strategies (ES) is proposed as a solution-finding method. The proposed modelling scheme is first applied to process control of a disc grinding process in the computer industry. A model for the material removal rate is constructed using the process data collected from the actual operation, and an adaptive controller based on the model is designed and implemented to achieve the required dimensional accuracy of ground parts. The potential improvement of process capability via adaptive control is demonstrated. Next, to implement the model-based optimization scheme for surface grinding processes, process models for grinding force, power, surface roughness, and residual stress are developed through designed experiments. Case studies are performed to demonstrate the efficacy and versatility of the proposed optimization method with various optimization objectives including minimization of grinding cost, minimization of cycle time, and process control. Finally, the optimal process conditions determined by the optimization scheme are validated by experimental results.
A Simple Procedure for the Evaluation of Fiber Size Effects on the Properties of Filament Wound Glass Fiber Composites (1992)

A method to fabricate flat laminates by filament winding was developed. Different fracture tests were then performed on materials with two different fiber size treatments. Based on the results, simple test methods sensitive to fiber size effects are suggested. Moisture conditioning was necessary for size effects to show.
SecourHealth: A Delay-Tolerant Security Framework for Mobile Health Data Collection (2014)

Security is one of the most imperative requirements for the success of systems that deal with highly sensitive data, such as medical information. However, many existing mobile health solutions focused on collecting patients' data at their homes that do not include security among their main requirements. Aiming to tackle this issue, this paper presents SecourHealth, a lightweight security framework focused on highly sensitive data collection applications. SecourHealth provides many security services for both stored and in-transit data, displaying interesting features such as tolerance to lack of connectivity (a common issue when promoting health in remote locations) and the ability to protect data even if the device is lost/stolen or shared by different data collection agents. Together with the system's description and analysis, we also show how SecourHealth can be integrated into a real data collection solution currently deployed in the city of Sao Paulo, Brazil.
Why There is an Increased Number of Deaths from Heroin Mixed with Fentanyl in the USA: Potential Roles of Unrecognized Hypomagnesemia and Elevated Levels of Ceramides and Platelet-Activating Factor Particularly in Brain Stem Area and Potential Relationship to Euphoria and Hallucinations (2019)

Currently, there is a widespread number of deaths, particularly in the USA, from ingestion/imbibing a combination of heroin and fentanyl. Young and old adults are becoming rapidly addicted to this drug combination. Many of these victims believe they are being sold heroin unaware that the latter is often "laced" with fentanyl. Until now, the mechanism(s) for inducing coma followed by death has been thought to be respiratory and cardiac failure. However, new evidence from human and experimental animal studies, reviewed herein, indicates a major underlying cause of euphoria, hallucinations, coma and death is a consequence of cerebrovascular actions in the cerebrum, medulla, and hippocampus which appears to be brought about by rapid, intracellular reduction in free magnesium ions coupled to elevation in cellular and blood levels of ceramides and platelet-activating factor.
Application Specific Standard Products with a 38.4GOPS Image Recognition Engine for Automotive Vision Applications (2008)

This paper describes Application Specific Standard Products (ASSPs), made up of an RISC processor, an image recognition engine, and peripherals, that have been developed as Systems on a Chip for automotive vision systems. These ASSPs are designed for automotive applications which use information about a vehicle's surroundings obtained from cameras and which need high speed processing for real-time systems control. A RISC processor and new image recognition engine are integrated onto a silicon chip in order to meet automotive specifications including cost and size. The image recognition engine based on local parallel architecture can compute a large amount of image data at high speed. The authors describe two ASSPs, one for general vision systems and the other for car navigation systems. They report on three practical applications to demonstrate the devices’ computational capabilities. These applications include road sign recognition for precise positioning; multitype lane marker recognition; and vehicle detection by voting edge-pair feature space. Sign recognition with one of the ASSPs, called SH7774, was especially successful in executing practical car navigation software and real-time sign recognition at the same time. The authors conclude that there are infinite possibilities for realizing safer and more easily operated vehicles by mounting cameras at the front, sides and rear to monitor and recognize the outside environment.
Asymptotically Optimal Scheduling Policy For Minimizing The Age of Information (2020)

In this paper, we consider the average age minimization problem where a central entity schedules M users among the N available users for transmission over unreliable channels. It is well-known that obtaining the optimal policy, in this case, is out of reach. Accordingly, the Whittle's index policy has been suggested in earlier works as a heuristic for this problem. However, the analysis of its performance remained elusive. In the sequel, we overcome these difficulties and provide rigorous results on its asymptotic optimality in the many-users regime. Specifically, we first establish its optimality in the neighborhood of a specific system's state. Next, we extend our proof to the global case under a recurrence assumption, which we verify numerically. These findings showcase that the Whittle's index policy has analytically provable optimality in the many-users regime for the AoI minimization problem. Finally, numerical results that showcase its performance and corroborate our theoretical findings are presented.