gebhart/patrepeval huggingface dataset:
Impact of microfluidization on colloidal properties of insoluble pea protein fractions (2021)

Abstract Microfluidization is a technique commonly used to disrupt and homogenize dispersions such as oil-in-water emulsions or cellular suspensions. In this study, we investigated its ability to alter the physicochemical properties of plant-derived insoluble protein aggregates such as those found in pea protein extracts. Insoluble pea protein dispersions (5% w/w, pH 7) were homogenized at 25–150 MPa for 1–5 cycles. Increasing the homogenization pressure and cycles decreased the particle size ( d 43 ) of the unhomogenized insoluble pea proteins from 180 ± 40 μm to 0.2 ± 0.0 μm (at ≥ 125 MPa), leading to more transparent dispersions. Furthermore, the solubility of the insoluble pea proteins increased from 23 ± 1% to 86 ± 4%. Treatments with chaotropic agents, dithiothreitol and urea, revealed that insoluble pea protein aggregates were stabilized not only by disulphide bonds but also by hydrogen bonds and hydrophobic interactions. These molecular interactions were disrupted by microfluidization. The study provides insights into the disruption mechanism of insoluble pea proteins by applying microfluidization and offers a mean to improve their technofunctional properties to facilitate further use in food manufacture.
Neuromolecular basis of faded perception associated with unreality experience (2018)

Perceptual changes in shape, size, or color are observed in patients with derealization symptoms; however, the underlying neural and molecular mechanisms are not well understood. The current study explored the relationship between neural activity associated with altered colorfulness perception assessed by fMRI and striatal dopamine D<sub>2</sub> receptor availability measured by [<sup>11</sup>C]raclopride PET in healthy participants. Inside an fMRI scanner, participants performed the saturation adaptation task, where they rated how much vivid/faded visual objects looked like real/unreal ones using a visual analog scale. We found that participants experienced greater unreality when they perceived fadedness than vividness despite physically identical saturation. The combined fMRI and PET analyses revealed that the faded perception-related activities of the dorsolateral prefrontal and parietal cortex were positively correlated with striatal D<sub>2</sub> receptor availability. This finding may help to understand the neuromolecular mechanisms of faded perception associated with feeling unreal in derealization symptoms.
Synthesis of ternary SiGeSn semiconductors on Si(100) via SnxGe1−x buffer layers (2003)

Single-phase Si1−x−yGexSny alloys with random diamond cubic structures are created on Si(100) via ultrahigh vacuum chemical vapor deposition reactions of SnD4 with SiH3GeH3 at 350 °C. Commensurate heteroepitaxy is facilitated by Ge1−xSnx buffer layers, which act as templates that can conform structurally and absorb the differential strain imposed by the more rigid Si and Si–Ge–Sn materials. The crystal structure, elemental distribution and morphological properties of the Si1−x−yGexSny/Ge1−xSnx heterostructures are characterized by high-resolution electron microscopy, including electron energy loss nanospectroscopy, x-ray diffraction (rocking curves) and atomic force microscopy. These techniques demonstrate growth of perfectly epitaxial, uniform and highly aligned layers with atomically smooth surfaces and monocrystalline structures that have lattice constants close to that of Ge. Rutherford backscattering ion channeling shows that the constituent elements occupy random substitutional sites in the same average diamond cubic lattice and the Raman shifts are consistent with the lattice expansion produced by the Sn incorporation into SiGe tetrahedral sites.
Electrical Characteristics of High Performance SPC and MILC p-Channel LTPS-TFT with High-κ Gate Dielectric (2009)

In this article, high performance p-channel, low temperature polysilicon thin-film transistors (LTPS-TFTs) are fabricated by using gate dielectric and two crystallization methods, solid phase crystallization (SPC) and metal-induced lateral crystallization (MILC) are compared. High field-effect mobility ( and ), ultralow subthreshold swing (SS and /decade), and low threshold voltage ( and ) are derived from SPC- and MILC-TFTs with gate dielectric, respectively. These excellent electrical characteristics are due to low trap states and much higher gate capacitance density with equivalent oxide thickness , resulting in lower operation voltage within of LTPS-TFT without any passivation method. The comparison of SPC and MILC p-channel LTPS-TFTs with gate dielectric is demonstrated.
Numerical Investigation of the Stability of Straight Twisted Vortices (2021)

View Video Presentation: https://doi.org/10.2514/6.2021-2935.vid In this work the topic of vortex stability in topologically defined vortices is explored via two methods. The numerical structure for linear stability analysis of these vortices is presented, highlighting the use of high-order compact finite-difference operators while still maintaining matrix sparsity. A method by which vortcies of arbitrary geometry can be defined and initialized on a grid is presented. These methods are further employed to study that dynamics of topologically defined vortices through high-fidelity simulations on a Cartesian grid with adaptive mesh refinement (AMR). The numerical linear stability analysis reveals that angular frequency of unstable modes is essentially asymptotic with the rate of twist. Moreover, the group velocity is shown to only vary in the low rate of twist/low wavenumber region. Results from the high-fidelity simulations show evidence of small-scale vortex re-connection events leading to the local destruction of helicity. Simulation results also yield an instability growth rate in fair agreement with that predicted with the linear stability code.
Designing Liposomal Anticancer Drug Formulations for Specific Therapeutic Applications (2000)

Click to increase image sizeClick to decrease image sizeKeywords:: Liposomal drug deliveryCancer therapyDoxorubicinVincristine
Interview. L’État est contraint, dans sa relation aux collectivités, à une autodiscipline (2019)

Le politologue Patrick Le Lidec observe l’évolution de l’autonomie des collectivités qui, du fait de l’européanisation des finances publiques, “s’insère dans un cadre plus serré que par le passé”. La soutenabilité des comptes publics modifie la relation de l’État aux territoires, souligne-t-il. Patrick Le Lidec interviendra à l’école d’été internationale de la chaire “Territoires et mutations de l’action publique” de Sciences Po Rennes, dont Acteurs publics est partenaire.
Upper Gastrointestinal Tract Bleeding (1981)

The mortality from upper gastrointestinal (GI) tract bleeding has remained constant at 10% during the past 40 years. Many drugs may precipitate upper GI tract bleeding by disrupting the gastric mucosal barrier. Aspirin-induced injury to the gastric mucosa and GI tract bleeding have been documented in many studies; some of the mechanisms involved are known, but others are still being investigated. An approach to the bleeding patient is suggested; initial resuscitation, history taking, physical examination, determination of bleeding levels, and diagnostic procedures to determine the cause of bleeding are reviewed. Also described are available therapies for GI tract bleeding-gastric lavage, drug therapy, endoscopic control, electrocautery, thermal probe, tissue adhesive, and laser photocoagulation. The merits of the argon laser and the neodymium-yttrium aluminum garnet laser (both still in experimental stages) are described and compared. No pharmacologic or endoscopic therapies for upper GI tract bleeding have been proved effective.
Pyranose Ring Flexibility. Mapping of Physical Data for Iduronate in Continuous Conformational Space (1998)

A method for relating pyranose ring conformation to experimental measurements is presented. A three-dimensional conformational space (Q, θ, P2) based on a torsion angle formalism is projected in two dimensions (θ, P2) and contours of calculable physical properties are plotted and compared to experimentally determined values. With this approach, conformations in a continuous conformational space that fit the physical data can be identified rapidly and the conformational space available to pyranose rings can be visualized easily. Iduronate, which is part of biologically important glycosaminoglycans such as dermatan sulfate, shows similar stability in several ring conformations. Thus, we find it is desired to extend the conformational analysis from canonical chair and skew-boat conformations to a continuous conformational space, when interpreting biophysical data related to the iduronate ring conformation. When the method is applied to the physical data available for dermatan sulfate, the results indicate that two families of α-l-iduronate conformations each can explain both 2D-NMR and X-ray diffraction data for dermatan sulfate. Further, the mapping technique was used to investigate the interconversion between different conformations of the iduronate residue. The method described here offers a systematic search of conformations beyond the canonical chair, boat, and skew boat conformations and provides a graphical description of the deviations from these ideal conformers. The approach thus can be extended to ring conformational analysis of other pyranoses.
Reliability Enhancement of 3G Radio Network Prediction by a Conditional Distribution Discrimination Tree (2008)

This paper presents a constructive learning system that enhances the reliability and precision of radio network predictions. This task is achieved by finding a correspondence between the probability density distributions of simulated predictions and real measurement data collected from the radio network. Once this correspondence is found, it is possible to arrive at more realistic prediction values from simulation results. After carrying out non-parametric estimations of the probability distributions of the simulations, feature vectors are computed from these estimations, followed by a supervised learning that finds a mapping between the feature vectors issued from the simulations and the estimations of conditional probability distributions of the measurements. The proposed method is evaluated on a 3G radio network using indicators such as UpLink (UL) and DownLink (DL) base station loads. Results show that the proposed scheme is able to yield distributions that are much closer to measurements than simulations. With such a technique, it is possible to predict with enhanced accuracy new configurations and conditions for which we don't have observations.
An Automated System for Epileptogenic Focus Localization in the Electroencephalogram (1999)

This paper describes an automated system for the detection and localization of foci of epileptiform activity in the EEG. The system detects sharp EEG transients (STs) in the process, but the emphasis is on epileptic focus localization. A combination of techniques involving signal processing, pattern recognition, and the expert rules of an experienced electroencephalographer, involving considerable spatiotemporal context information, is applied to multichannel EEG data. An overall emphasis on minimizing the number of false-positive sharp transient detections drives the system design. Tested on data from 13 subjects with epileptiform activity and 5 controls, all areas of focal epileptiform activity were detected by the system, although not all of the contributing foci were reported separately. Two false-positive foci were detected as well due to nonfocal spike activity and normal spike-like activity not present in the training set. The system detected 95.7% of the epileptiform events constituting the correctly detected foci, with a false detection rate of 11.1%.
SATURN (2020)

We envision a new generation of computation devices, computational materials , which are self-sustainable, cheaply manufactured at scale and exhibit form factors that are easily incorporated into everyday environments. These materials can enable ordinary objects such as walls, carpet, furniture, jewelry, and cups to do computational things without looking like today's computational devices. Self-powered Audio Triboelectric Ultra-thin Rollable Nanogenerator (SATURN) is an early example of a computational material that can sense vibration, such as sound. SATURN can be manufactured from inexpensive components, is flexible so that it can be integrated into many different surfaces, and powers itself through the sound or vibration it is sensing. Using radio backscatter, we demonstrate that SATURN's sensed data is passively transmitted to remote computers, alleviating the need for batteries or any wired power for the material itself. The proliferation of these types of computational materials ushers an era of Internet of Materials, further blurring the distinction between the physical and digital worlds.
Up-regulation of steroid sulphatase activity in HL60 promyelocytic cells by retinoids and 1α,25-dihydroxyvitamin D3 (2001)

HL60 promyeloid cells express both classes of oestrogen receptor (ERalpha and ERbeta). We show that hydrolysis of oestrone sulphate by steroid sulphatase is a major source of oestrone in HL60 cells, and that most of the released oestrone is not metabolized further to 17beta-oestradiol. Treatment of HL60 cells with retinoids or 1alpha,25-dihydroxyvitamin D3 increased steroid sulphatase mRNA and activity in parallel with the induction of CD11b, an early marker of myeloid differentiation that is expressed before the differentiating cells stop proliferating. Use of agonists and antagonists against retinoid receptor-alpha and retinoid receptor-X revealed that both classes of retinoid receptor can drive steroid sulphatase up-regulation. Steroid sulphatase activity fluctuates during the cell cycle, being highest around the transition from G1 to S phase. During the differentiation of HL60 cells induced by all-trans-retinoic acid or 1alpha,25-dihydroxyvitamin D3, there is increased conversion of 17beta-oestradiol into oestrone by an oxidative 17beta-hydroxysteroid dehydrogenase. Treatment of Caco-2 colon adenocarcinoma cells with all-trans-retinoic acid or 1alpha,25-dihydroxyvitamin D3 also increases 17beta-oestradiol oxidation to oestrone. An increase in local oestrone production therefore occurs in multiple cell types following treatment with retinoids and 1alpha,25-dihydroxyvitamin D3. The possible involvement of locally produced oestrogenic steroids in regulating the proliferation and differentiation of myeloid cells is discussed.
Isolated, Circularly Polarized, Attosecond Pulse Generation (2016)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text P. Huang, C. Lu, C. Hernandez-Garcia, R. Huang, P. Wu, D. D. Hickstein, D. Thrasher, J. L. Ellis, A. H. Kung, S. Yang, A. Jaron-Becker, A. Becker, H. C. Kapteyn, M. M. Murnane, C. G. Durfee, and M. Chen, "Isolated, Circularly Polarized, Attosecond Pulse Generation," in Conference on Lasers and Electro-Optics, OSA Technical Digest (online) (Optica Publishing Group, 2016), paper JTh4A.7. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Use of Computer Vision for Monitoring of Slow Varying Displacements on Subsea Structures (2022)

Abstract Structural monitoring of subsea structures is very common in the oil and gas industry. Monitoring may be performed to keep track of e.g. position, movements, loads and fatigue accumulation. Well growth of subsea wells is a slow process, and traditional accelerometer-based monitoring is not feasible. The objective of this paper is to present the camera-based monitoring campaign of the subsea wellheads on the Norwegian continental shelf. The paper gives a brief introduction to the issue around well growth and how that potentially can lead to fatigue issues. Further we give an overview of the theory behind marker-based monitoring and explain how this is used in practice by presenting experience from a measurement campaign where 2 different battery powered camera kits operated subsea for 5 months. This to enable establishment of the fatigue integrity of the subsea wellheads. The paper will show how the experience from this campaign has been used to create a new and improved camera kit for more efficient monitoring of similar issues in the future. The technology can be used in a wide range of subsea applications for monitoring slowly variating relative displacements.
Dynamic regulation of functionally distinct virus-specific T cells (2010)

The functional capacities of CD8(+) T cells important for virus clearance are influenced by interactions with antigen presenting cells (APCs) and CD4(+) T cells during initial selection, subsequent expansion, and development of memory. Recently, investigators have shown that polyfunctional T cells correlate best with long-term protection, however, it is still unknown how to stimulate T cells to achieve these responses. To study this, we examined the phenotypes and functions of CD8(+) T cells specific for two different virus antigens stimulated ex vivo using either autologous monocyte-derived dendritic cells (moDCs) or HLA-A2-Ig-based artificial APCs (aAPCs). Although similar numbers of influenza virus and measles virus tetramer-positive cells were generated by stimulation with peptide-loaded moDCs and aAPCs, T cell function, assessed by expression of IL-2, IFN-gamma, TNF-alpha, MIP1beta, and CD107a, showed that aAPC-generated CD8(+) T cells were multifunctional, whereas moDC-generated cells were mostly monofunctional. aAPC-generated cells also produced more of each cytokine per cell than CD8(+) T cells generated with moDCs. These phenotypes were not fixed, as changing the culture conditions of expanding T cells from aAPCs to moDCs, and moDCs to aAPCs, reversed the phenotypes. We conclude that CD8(+) T cells are heterogeneous in their functionality and that this is dependent, in a dynamic way, on the stimulating APC. These studies will lead to understanding the factors that influence induction of optimal CD8(+) T cell function.
ChemInform Abstract: Asymmetric Additions to Chiral Naphthyloxazolines. An Entry into Tetracyclic Terpene Ring Systems Related to Aphidicolin, Scopadulcic Acid, and Kauranes. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereocontrolled Glycosylations via Addition of Sulfur Electrophiles to Glycals. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Dataset for Self-affine Graphene Metasurfaces for Tunable Broadband Absorption (2016)

Dataset for: Wu, Pin Chieh, Papasimakis, Nikitas and Tsai, Din Ping (2016) Self-affine graphene metasurfaces for tunable broadband absorption. Physical Review Applied. Data for Figs 2, 3, 4, 5 of the paper. Fieldmaps are provided as bitmaps.
Large-scale plasmonic microarrays for label-free high-throughput screening (2011)

Microarrays allowing simultaneous analysis of thousands of parameters can significantly accelerate screening of large libraries of pharmaceutical compounds and biomolecular interactions. For large-scale studies on diverse biomedical samples, reliable, label-free, and high-content microarrays are needed. In this work, using large-area plasmonic nanohole arrays, we demonstrate for the first time a large-scale label-free microarray technology with over one million sensors on a single microscope slide. A dual-color filter imaging method is introduced to dramatically increase the accuracy, reliability, and signal-to-noise ratio of the sensors in a highly multiplexed manner. We used our technology to quantitatively measure protein-protein interactions. Our platform, which is highly compatible with the current microarray scanning systems can enable a powerful screening technology and facilitate diagnosis and treatment of diseases.
A Dynamically Focusing Cochlear Implant Strategy Can Improve Vowel Identification in Noise (2018)

These initial results suggest that further exploration of dynamic focusing is warranted. Specifically, optimizing such strategies on an individual basis may lead to improvements in speech perception for more adult listeners and improve how CIs are tailored. Some listeners may also need a longer period of time to acclimate to a new program.
LOCALIZATION OF SH‐PTP1 TO SYNAPTIC VESICLES: A POSSIBLE ROLE IN NEUROTRANSMISSION (1997)

The tyrosine kinase pp60src is known to phosphorylate synaptophysin and in doing so may regulate neurotransmitter release. The tyrosyl phosphorylated state of synaptophysin is dependent on pp60src kinase and the unknown protein tyrosine phosphate phosphohydrolase (PTPase, EC 3.1.3.48). Here we report the protein tyrosine phosphate phosphohydrolase SH-PTP1, to associate with synaptic vesicles and interact with synaptophysin. These studies identify SH-PTP1 as a new member of the secretory machinery at the nerve terminal and suggest its involvement in neurotransmission.
Formation of Biocompatible Nanocapsules with Emulsion Core and Pegylated Shell by Polyelectrolyte Multilayer Adsorption (2010)

The aim of this work was to develop a novel method of preparation of loaded nanosize capsules based on liquid core encapsulation by biocompatible polyelectrolyte (PE) multilayer adsorption, with or without pegylated outermost layer. Using AOT (docusate sodium salt) as emulsifier, we obtained cores, stabilized by an AOT/PLL (poly-L-lysine hydrobromide) surface complex. These positively charged cores were encapsulated by layer-by-layer adsorption of polyelectrolytes, biocompatible polyanion PGA (poly-L-glutamic acid sodium salt), and biocompatible polycation PLL. We used the saturation method for formation of consecutive layers, and we determined the optimal conditions concerning concentration of surfactant and polyelectrolytes to form stable shells. The average size of the obtained capsules was 60 nm. Pegylated external layer were prepared using PGA-g-PEG (PGA grafted by PEG poly(ethylene glycol)). The capsules were stable for at least a period of 3 months. These nanocapsules were biocompatible when tested for cytotoxicity in a cellular coculture assay and demonstrated no or very low nonspecific binding to peripheral blood mononuclear cells when tested by flow cytometry. In order to study drug effects on leukemia cells, beta-carotene and vitamin A have been encapsulated as model drugs.