gebhart/patrepeval huggingface dataset:
Correlating Sulfur Solubility with Short-to-Intermediate Range Ordering in the Structure of Borosilicate Glasses (2022)

The present study focuses on understanding the structural dependence of sulfur (as SO3) solubility in Na2O–B2O3–SiO2 glasses over a broad composition space exhibiting a rich variety of structural associations. The focus is on probing the impact of the (1) structural role of Na+, (2) degree of polymerization, and (3) network former connectivity (formation of Si–O–B and B–O–B linkages) on sulfur solubility in borosilicate glasses. By employing a suite of state-of-the-art characterization techniques, including inductively coupled plasma-optical emission spectroscopy (ICP-OES), magic-angle spinning (MAS) NMR spectroscopy, and Raman spectroscopy, an inverse correlation has been established between the sulfur solubility and the degree of network polymerization in the glasses across the investigated composition space. While the modification of SO3 leading to the formation of SO42– can successfully compete with the network depolymerization mechanisms (i.e., creation of nonbridging oxygens) and induce repolymerization in the glass network, the BO3 → BO4 conversion facilitated by the charge compensation by alkali cations takes precedence. The results from this study, when extended to more complex borosilicate-based glass compositions, will not only add to our understanding of the fundamental science controlling the sulfur solubility in borosilicate-based real-world nuclear waste glasses but will also form a basis for the development of nonempirical quantitative structure–property relationship (QSPR)-based predictive models.
IMD Components Compensation Conditions for Dual-Band Feed-Forward Power Amplifier (2020)

This paper presents analysis results of the intermodulation distortion (IMD) components compensation conditions for dual-band feed-forward power amplifier (FFPA) when inputting dual-band signals simultaneously. The signal cancellation loop and distortion cancellation loop of the dual-band FFPA have frequency selective adjustment paths which consist of filter and vector regulator. The filter selects the desired frequency component and suppresses the undesired frequency component in the desired frequency selective adjustment path. The vector regulators repeatedly adjust the amplitude and phase values of the composite components for the desired and suppressed undesired frequency components. In this configuration, the cancellation levels of the signal cancellation loop and distortion cancellation loop are depending on the amplitude and phase errors of the vector regulator. The analysis results show that the amplitude and phase errors of the desired frequency component almost become independent that of the undesired frequency component in a weak non-linearity condition, when the isolation between the desired band and the undesired band given by the filter is more than 40 dB. The amplitude errors of the desired frequency component are dependent on that of the undesired frequency component in a strong non-linear conditions when the isolation level sets as above. A 1-W-class signal cancellation loop and 20-W-class FFPA are fabricated for 1.7-GHz and 2.1-GHz bands simultaneous operation. The experimental results show that the analysis results are suitable in the experimental conditions. From these investigations, the analysis results can provide a commercially available dual-band FFPA. To our best knowledge, this is first analysis results for the dual-band FFPA.
ChemInform Abstract: α‐Amino Acid Phenolic Ester Derivatives: Novel Water‐Soluble General Anesthetic Agents Which Allosterically Modulate GABAA Receptors. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Adaptive fusion by reinforcement learning for distributed detection systems (1996)

Chair and Varshney (1986) have derived an optimal rule for fusing decisions based on the Bayeslan criterion. To implement the rule, the probability of detection P/sub D/ and the probability of false alarm P/sub F/ for each detector must be known, but this information is not always available in practice. An adaptive fusion model which estimates the P/sub D/ and P/sub F/ adaptively by a simple counting process is presented. Since reference signals are not given the decision of a local detector is arbitrated by the fused decision of all the other local detectors. Furthermore, the fused results of the other local decisions are classified as "reliable" and "unreliable". Only reliable decisions are used to develop the rule. Analysis on classifying the fused decisions in term of reducing the estimation error is given, and simulation results which conform to our analysis are presented.
3D printed cellular solid outperforms traditional stochastic foam in long-term mechanical response (2016)

3D printing of polymeric foams by direct-ink-write is a recent technological breakthrough that enables the creation of versatile compressible solids with programmable microstructure, customizable shapes, and tunable mechanical response including negative elastic modulus. However, in many applications the success of these 3D printed materials as a viable replacement for traditional stochastic foams critically depends on their mechanical performance and micro-architectural stability while deployed under long-term mechanical strain. To predict the long-term performance of the two types of foams we employed multi-year-long accelerated aging studies under compressive strain followed by a time-temperature-superposition analysis using a minimum-arc-length-based algorithm. The resulting master curves predict superior long-term performance of the 3D printed foam in terms of two different metrics, i.e., compression set and load retention. To gain deeper understanding, we imaged the microstructure of both foams using X-ray computed tomography, and performed finite-element analysis of the mechanical response within these microstructures. This indicates a wider stress variation in the stochastic foam with points of more extreme local stress as compared to the 3D printed material, which might explain the latter's improved long-term stability and mechanical performance.
IRAC : Insecticide Resistance and Mode‐of‐action Classification of Insecticides (2019)

The Insecticide Resistance Action Committee (IRAC) was formed in 1984 to provide a coordinated crop protection industry response to either prevent or delay the development of resistance in insect and mite pests. The mission of the IRAC is to facilitate communication and education on insecticide resistance, and to promote the development of resistance management strategies in crop protection and vector control, so as to maintain efficacy and support sustainable agriculture and improved public health. The IRAC groups are actively involved and on certain occasions provide funding for a variety of resistance management projects around the world. The IRAC mode-of-action (MoA) classification provides farmers, growers, advisors, extension staff, consultants, and crop protection professionals with a guide to the selection of insecticides or acaricides for use in a rotation-based approach that can provide effective and sustainable insecticide resistance management (IRM) or acaricide resistance management strategy.
PHITE: Precision High Intensity Training Through Epigenetics (2020)

PURPOSE: To investigate and mechanistically link acute molecular changes in the mRNA transcriptome and splice variant profile, miRNA profile, DNA methylome, and histone acetylation profile to changes in performance from exercise training. PHITE will: (1) Reveal potential molecular mechanisms underlying training and detraining adaptations; (2) Differentiate molecular responses to moderate vs. high intensity training, and identify potential underpinnings of inter-individual response heterogeneity; (3) Perform a rigorous proof-of-concept epigenomic biomarker study that scales to and improves Navy physical training. METHODS: This is an ongoing single-blind randomized trial of 18-27 y/o untrained adults. Participants are randomized to moderate or high intensity combined training 3 d/wk x 12 wk, followed by a 4-wk detraining period. Participants perform an acute exercise bout at wks 0 and 12 to assess acute molecular responses to exercise in untrained and trained states with serial biospecimen (muscle, blood) collections; repeated after 4 wk of detraining. Performance/phenotyping at wks 0 and 12 include aerobic power (VO2peak), strength, anaerobic power, explosive power, body composition (DXA), and phenotyping of blood and muscle. Because the trial is ongoing, randomized assignment remains blinded as groups A and B. Blinded phenotyping data were analyzed using repeated measures ANOVA for the effects of time (T), dose (A vs. B) and dose x time interaction. RESULTS: Phenotyping data on the first 51 completed participants confirm significant training effects and early indices of differential adaptations by exercise dose, along with substantial inter-individual response heterogeneity. Differential molecular mapping responses demonstrate sensitivity to exercise dose (A vs. B), timing of sample collection post-exercise, and training state (untrained vs trained vs detrained). CONCLUSION: Molecular response patterns to dose A vs. dose B share limited commonality, and differential responses across individuals provide novel preliminary evidence that dose-specific and individual-specific molecular response patterns may enable discrimination of adaptability.
Channel Reciprocity Calibration for Hybrid Beamforming in Distributed MIMO Systems (2023)

Time Division Duplex (TDD)-based distributed massive MIMO systems are envisioned as candidate solution for the physical layer of 6G multi-antenna systems supporting cooperative hybrid beamforming that heavily relies on the obtained uplink channel estimates for efficient coherent downlink pre-coding. However, due to the hardware impairment between the transmitter and the receiver, full channel reciprocity does not hold between the downlink and uplink direction. Such reciprocity mismatch deteriorates the performance of mm-Wave hybrid beam-forming and has to be estimated and compensated for, to avoid performance degradation in the co-operative hybrid beamforming.In this paper, we address the channel reciprocity calibration between any two nodes at two levels. We decompose the problem into two sub-problems. In the first sub-problem, we calibrate the digital chain, i.e. obtain the mismatch coefficients of the (DAC/ADC) up to a constant scaling factor. In the second sub-problem, we obtain the (PA/LNA) mismatch coefficients. At each step, we formulate the channel reciprocity calibration as a least-square optimization problem that can efficiently be solved via conventional methods such as alternative optimization with high accuracy. Finally, we verify the performance of our channel reciprocity calibration approach through extensive numerical experiments.
COVID-19 outcomes among hospitalized men with or without exposure to alpha-1-adrenergic receptor blocking agents (2021)

Abstract Importance Alpha-1-adrenergic receptor antagonists (α 1 -blockers) can abrogate pro-inflammatory cytokines and may improve outcomes among patients with respiratory infections. Repurposing readily available drugs such as α 1 -blockers could augment the medical response to the COVID-19 pandemic. Objective To evaluate the association between α 1 -blocker exposure and COVID-19 mortality Design Real-world evidence study Setting Patient level data with 32,355 records tested for SARS-CoV-2 at the Mount Sinai Health System including 8,442 laboratory-confirmed cases extracted from five member hospitals in the New York City metropolitan area. Participants 2,627 men aged 45 or older admitted with COVID-19 between February 24 and May 31, 2020 Exposures α 1 -blocker use as an outpatient or while admitted for COVID-19 Main Outcomes and Measures In-hospital mortality Results Men exposed to α 1 -blockers (N=436) were older (median age 73 vs. 64 years, P&lt;0.001) and more likely to have comorbidities than unexposed men (N=2,191). Overall, 758 (28.9%) patients died in hospital, 1,589 (60.5%) were discharged, and 280 (10.7%) were still hospitalized as of May 31, 2020. Outpatient exposure to α 1 -blockers was not associated with COVID-19 hospital outcomes, though there was a trend towards significance (OR 0.749, 95% CI 0.527-1.064; P=0.106). Conversely, inpatient use of α 1 -blockers was independently associated with improved in-hospital mortality in both multivariable logistic (OR 0.633, 95% CI 0.434-0.921; P=0.017) and Cox regression analyses (HR 0.721, 95% CI 0.572-0.908; P=0.006) adjusting for patient demographics, comorbidities, and baseline vitals and labs. Age-stratified analyses suggested greater benefit from inpatient α 1 -blocker use among younger age groups: Age 45-65 OR 0.384, 95% CI 0.164-0.896 (P=0.027); Age 55-75 OR 0.511, 95% CI 0.297-0.880 (P=0.015); Age 65-89 OR 0.810, 95% CI 0.509-1.289 (P=0.374). Conclusions and Relevance Inpatient α 1 -blocker use was independently associated with improved COVID-19 mortality among hospitalized men. Clinical trials to assess the therapeutic value of α 1 -blockers in COVID-19 are warranted.
A PANI supported lipid bilayer that contains NhaA transporter proteins provides a basis for a biomimetic biocapacitor (2019)

We designed a supported lipid bilayer (SLB) biomimetic membrane system that comprised polyaniline (PANI) to support a lipid bilayer membrane that incorporated Na+/H+ transporter proteins (NhaA) to give the system the capability of controllable electrogenic ion transport. The high turnover rate of NhaA (∼105 per min) provides the basis for this PANI-SLB-NhaA system to be a high-speed rechargeable biocapacitor that functions as a low-energy-consuming fast switch for biological engineering applications.
Plan of Township No. 9: compiled from the proprietors' plans and the descriptions in the leases and deeds, with additions and corrections from the various surveys made up to 1909 by Thomas W. May L. S. (1909)

Plan of Lot 9 compiled from the proprietors plans and the descriptions in the leases and deeds, with additions and corrections from the various surveys. The map shows Lot 9 divided into parcels of land with names of residents, their acreage amounts and land conveyance references handwritten in black and red ink. Shows the P.E.I. Railway in red, roads in brown. Bodies of water, which include Egmont Bay and the Brae River, are coloured blue. Compass rose with north and magnetic north arrows with variation for 1764.
Crystallization and preliminary crystallographic analysis of the type IIL restriction enzymeMmeI in complex with DNA (2011)

Type IIL restriction enzymes have rejuvenated the search for user-specified DNA binding and cutting. By aligning and contrasting the highly comparable amino-acid sequences yet diverse recognition specificities across the family of enzymes, amino acids involved in DNA binding have been identified and mutated to produce alternative binding specificities. To date, the specificity of MmeI (a type IIL restriction enzyme) has successfully been altered at positions 3, 4 and 6 of the asymmetric TCCRAC (where R is a purine) DNA-recognition sequence. To further understand the structural basis of MmeI DNA-binding specificity, the enzyme has been crystallized in complex with its DNA substrate. The crystal belonged to space group P1, with unit-cell parameters a = 61.73, b = 94.96, c = 161.24 Å, α = 72.79, β = 89.12, γ = 71.68°, and diffracted to 2.6 Å resolution when exposed to synchrotron radiation. The structure promises to reveal the basis of MmeI DNA-binding specificity and will complement efforts to create enzymes with novel specificities.
Evidence Based Clinical Practice: A Primer for Urologists (2007)

Knowledge, practice and documentation of evidence based clinical practice are of increasing importance to every urologist. Urologists should embrace evidence based clinical practice principles by acquiring the necessary skills to critically appraise the literature for the best evidence applicable to patient care.
The effect of fabric movement on washing performance in a front-loading washer V: Focusing on the role and shape of the lifter (2017)

When washing clothes in a front-loading washer, the lifter affects fabric movement and detergency by lifting up the fabric and then making it fall. In order to clarify the role of the lifter in a front-loading washer, fabric movement, and detergency were examined with or without a lifter. Seven factors are involved in the lifter shape, namely back width ( W b ), middle width ( W m ), front width ( W f ), the ratio between the top and bottom width ( c), back height ( H b ), front height ( H f ), and length ( L), which were altered to identify the most effective factors in the lifter shape and how fabric movement and detergency were changed according to lifter shape. When the middle width ( W m ), length ( L), and gap between the back height ( H b ) and the front height ( H f ) were increased, fabric movement became more complex and detergency was also increased. A new lifter developed by optimizing these shape factors showed 6.8% higher detergency than a conventional lifter.
The Scope of Analytical Chemistry (2015)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTThe Scope of Analytical ChemistryJonathan V. Sweedler, Daniel W. Armstrong, Yoshinobu Baba, Gert Desmet, Norman Dovichi, Andrew Ewing, Catherine C. Fenselau, Robert T. Kennedy, Cynthia K. Larive, Frances S. Ligler, Richard L. McCreery, Reinhard Niessner, Jeanne E. Pemberton, Weihong Tan, David R. Walt, John R. Yates, III, Renato Zenobi, and Xinrong ZhangCite this: Anal. Chem. 2015, 87, 13, 6425Publication Date (Web):June 18, 2015Publication History Published online18 June 2015Published inissue 7 July 2015https://doi.org/10.1021/acs.analchem.5b02231Copyright © 2015 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views9969Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (121 KB) Get e-AlertsSUBJECTS:Analytical chemistry,Computer simulations,Kinetic parameters,Modification Get e-Alerts
Context-based page unit recommendation for web-based sensemaking tasks (2009)

Sensemaking tasks require that users gather and comprehend information from many sources to answer complex questions. Such tasks are common and include, for example, researching vacation destinations or performing market analysis. In this paper, we present an algorithm and interface which provides context-based page unit recommendation to assist in connection discovery during sensemaking tasks. We exploit the natural note-taking activity common to sensemaking behavior as the basis for a task-specific context model. Our algorithm then dynamically analyzes each web page visited by a user to determine which page units are most relevant to the user's task. We present the details of our recommendation algorithm, describe the user interface, and present the results of a user study which show the effectiveness of our approach.
Appertization (2016)

This Glossary of Terms Related to Pharmaceutics is needed by practitioners in the field of pharmaceutics as this field fulfills an important and crucial role, different from the roles of other scientific disciplines involved in the drugmaking process. The glossary contains 168 definitions used in pharmaceutics. These are related to various aspects of this discipline, such as: (1) physicochemical characterization of pharmaceutical preparations and the active ingredients they contain; (2) unit operations used in the practice of pharmaceutics; (3) terms related to the various dosage forms; (4) terms related to the various modes and routes of drug delivery; (5) terms used in pharmacokinetics and biopharmaceutics in general; and additional miscellaneous terms. The field of pharmaceutics itself is of a multidisciplinary nature as its practitioners come from a variety of disciplines, such as chemistry or various biological sciences, thus a glossary containing authoritative definitions would be useful for them. The terms used in pharmaceutics are rarely covered by existing glossaries, and in the cases they are, their definitions are often inappropriate for the field of pharmaceutics and require new or modified definitions to better fit the new context.
Effect of VEGF Trap on Normal Retinal Vascular Development and Oxygen-Induced Retinopathy in the Dog (2011)

Purpose. To evaluate the effects of a vascular endothelial growth factor trap (VEGF Trap) on retinal vascular development and pathologic neovascularization (NV) in the canine model of oxygen-induced retinopathy (OIR). Methods. Newborn dogs (postnatal day [P]1) were exposed to 100% O(2) and then returned to room air on P5. VEGF Trap (5, 25, or 250 μg) was injected intravitreally in one eye and human FC (hFc) injected in the fellow eye of air control and oxygen-treated dogs on P8. The retinal vasculature and NV were evaluated on P21. Other oxygen-exposed animals received 5 μg of VEGF Trap or hFc on P22 after confirmation of retinopathy of prematurity (ROP)-like pathology and were evaluated at P45. Results. In air controls, both the vascularized area of the retina and the density of superficial capillaries were reduced in 250 or 25 μg VEGF Trap-injected eyes, and deep capillaries were absent. Eyes that received the 5 μg dose were indistinguishable from controls. In oxygen-treated animals, all eyes injected with VEGF Trap exhibited markedly less intravitreal NV than that of hFc-injected fellow eyes, irrespective of dose. Retinal vascular area in OIR animals was significantly reduced in eyes injected with 250 or 25 μg of VEGF Trap, but the 5 μg dose did not inhibit retinal revascularization. Eyes with existing NV that received 5 μg VEGF Trap at P22 exhibited substantial resolution of OIR pathology at P45. Conclusions. The VEGF Trap inhibited the formation of NV, but higher doses also inhibited revascularization of retina when injected at P8. In contrast, the lowest dose tested effectively blocked NV and caused regression of existing NV, without appreciably affecting vasculogenesis or retinal revascularization. These findings suggest that dose selection is an important variable when considering the use of VEGF-targeting agents for the treatment of ROP.
High-Yield Large-Scale Optical Phased Array with Flip-Chip CMOS ASIC (2023)

We present &gt;99% yield and consistent beam forming performance across ten optical phased array modules each with a 1024-element array, flip-chip assembled CMOS ASIC, and interfacing microcontroller, enabling robust performance in applications such as LiDAR.