gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Epitaxial Growth and Application of Transparent Oxide Semiconductors (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Can the model for end-stage liver disease score replace the indocyanine green clearance test in the selection of right hemihepatectomy in Child-Pugh class A? (2014)

MELD score does not accurately predict hepatic function after right hemihepatectomy in patients with resectable HBV-related HCC. MELD scores were not correlated with the ICG-R15 values in patients with Child-Pugh class A.
The development of lower limb musculoskeletal models with clinical relevance is dependent upon the fidelity of the mathematical description of the lower limb. Part 1: equations of motion (2012)

Contemporary musculoskeletal modelling research is based upon the assumption that such models will evolve into clinical tools that can be used to guide therapeutic interventions. However, there are a number of questions that must be addressed before this becomes a reality. At its heart, musculoskeletal modelling is a process of formulating and then solving the equations of motion that describe the movement of body segments. Both of these steps are challenging. This article argues that traditional approaches to musculoskeletal modelling have been heavily influenced by the need to simplify this process (and in particular the solution process), and that this has to some degree resulted in approaches that are contrary to the principles of classical mechanics. It is suggested that future work is required to understand how these simplifications affect the outputs of musculoskeletal modelling studies. Equally, to increase their clinical relevance, the models of the future should adhere more closely to the classical mechanics on which they are based.
Temperature-Jump 2D NMR Spectroscopy in Crystalline Solids:  A Technique for Correlating Molecular Reorientation across the Phase Boundaries of an Order−Disorder Lattice (1998)

We describe a two-dimensional high-resolution solid-state NMR methodology for correlating the dynamics of molecular rearrangements around the critical points of equilibrium phase transitions in molecular solids. It combines the techniques of temperature-jump and two-dimensional (2D) NMR spectroscopy. The two spectral dimensions are the isotropic chemical shifts at different sample temperatures. The technique is illustrated by elucidating the dynamic rearrangement of the C4O4 units of squaric acid (H2C4O4) in relationship to the mechanism of its antiferroelectric phase transition at TN ∼ 373 K. These results clarify the apparent discrepancy between the conclusions derived earlier from NMR, X-ray, and Raman and neutron scattering studies. They were a direct consequence of the significant enhancement in the NMR spectral resolution through this technique, which thus might prove to be a significant new aid in understanding the mechanisms of phase transitions in molecular solids.
Effects of Processing Methods on the Proximate Composition and Momordicosides K and L Content of Bitter Melon Vegetable (2007)

Bitter melon (Mormodica charantia L.) has been associated with health benefits such as hypoglycemic, antiatherogenic, and anti-HIV activities. The vegetable, however, has an unpleasant bitter taste. The purpose of this research was to establish the effect of various processing methods on the moisture, lipid, and protein content of the Sri Lanka variety of bitter melon and to determine the effect of the processing methods on momordicosides K and L contents. The processing methods used were frying, blanching, sun drying, oven drying, freeze drying, and bitter masking with five different commercial bitter masking agents. Moisture, lipid, and protein analyses were done using standard AACC methods. Drying decreased moisture content from 92% to 9.5-10.2%. Frying lowered moisture content to 0.8% while increasing lipid content from 3.6 to 67%. Protein content remained unaffected by treatments. A liquid chromatography-electrospray ionization-mass spectrometry (LC/ESI/MS) method was used to identify momordicosides K and L in methanolic extracts of fresh and processed samples. Only extracted ion chromatographs for blanched bitter melon and bitter melon with MY 68 agent showed the absence of momordicosides K and L.
SummerTime: Text Summarization Toolkit for Non-experts (2021)

Recent advances in summarization provide models that can generate summaries of higher quality. Such models now exist for a number of summarization tasks, including query-based summarization, dialogue summarization, and multi-document summarization. While such models and tasks are rapidly growing in the research field, it has also become challenging for non-experts to keep track of them. To make summarization methods more accessible to a wider audience, we develop SummerTime by rethinking the summarization task from the perspective of an NLP non-expert. SummerTime is a complete toolkit for text summarization, including various models, datasets and evaluation metrics, for a full spectrum of summarization-related tasks. SummerTime integrates with libraries designed for NLP researchers, and enables users with easy-to-use APIs. With SummerTime, users can locate pipeline solutions and search for the best model with their own data, and visualize the differences, all with a few lines of code. We also provide explanations for models and evaluation metrics to help users understand the model behaviors and select models that best suit their needs. Our library, along with a notebook demo, is available at https://github.com/Yale-LILY/SummerTime.
Uniform semiclassical treatment of the radial coupling term in the adiabatic basis: Application to the excitation transfer He(1S)+Ne2+(1D)→He(1S)+Ne2+(1S) (1988)

We present a uniform semiclassical analysis of the radial coupling A(r)(d/dr) in the adiabatic basis. Various approximations are tested for solving the perturbative form of the probability integrals. Our model is applied to the excitation transfer He${(}^{1}$S)+${\mathrm{Ne}}^{2}$+${(}^{1}$D)\ensuremath{\rightarrow}He${(}^{1}$S)+${\mathrm{Ne}}^{2+}$${(}^{1}$S). The results we obtain are in good agreement among themselves and provide an alternative model in the adiabatic frame to complete the current Landau-Zener-St\"uckelberg--like calculations. The dominating role of the turning points in such curve-crossing problems is also demonstrated.
Direct light field rendering without 2D image generation (2016)

Abstract Rapid developments in 3D display technologies have enabled consumers to enjoy 3D environments in an increasingly immersive manner through various display systems such as stereoscopic, multiview, and light field displays. However, there is a corresponding increase in the complexity of the conventional multiview rendering process in the attempt to achieve a sufficient level of reality, which may hinder the further commercial viability of 3D display products based on such a conventional approach. This paper proposes a novel method, the so‐called direct light field rendering , which can compose the display 3D panel image without reconstructing all the multiview images beforehand. Interpreting the 3D display as sampling in the light field domain, we attempt to directly compute only the necessary samples, not the entire light fields or multiview images. Our proposed algorithm involves the solving of linear systems of two variables, thereby requiring remarkably low computational complexities. Experimental results show that the computation time and memory usage remain as little as 12% and 1% of those required by the conventional one.
Potential constants of manganese pentacarbonyl bromide from the vibrational spectra of isotopic species (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPotential constants of manganese pentacarbonyl bromide from the vibrational spectra of isotopic speciesDavid K. Ottesen, Harry B. Gray, Llewellyn H. Jones, and Maxwell GoldblattCite this: Inorg. Chem. 1973, 12, 5, 1051–1061Publication Date (Print):May 1, 1973Publication History Published online1 May 2002Published inissue 1 May 1973https://pubs.acs.org/doi/10.1021/ic50123a015https://doi.org/10.1021/ic50123a015research-articleACS PublicationsRequest reuse permissionsArticle Views124Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Abstract 3171: Stromal palladin is a poor prognostic marker in renal cell carcinoma (2011)

Abstract Renal cell carcinoma (RCC) is a fatal disease in urgent need of novel diagnostic and treatment tools. Metastasis to the secondary site is the main cause of death in RCC. Although renal tumor cells are intercalated within a mesenchymal stromal microenvironment during RCC tumorigenesis, not much is known about this specific stroma. Therefore, questioning the specific importance of RCC's stroma is of noteworthy interest. In this study we questioned whether stromal and tumor components progress at similar rates and whether assessing rates of stromal progression are of clinical importance. Our experimental system uses fibroblasts harvested from patient matched normal kidney, as well as primary and secondary RCC surgical samples. We tested several stromal markers such as actin binding protein palladin, alpha-smooth muscle actin and fibronectin spliced form EDA, all known to be upregulated in tumor associated stroma, and uncovered that their expression levels depend on the production of stromal extracellular matrices (ECMs) using an in vitro 3-D stromal system derived from the harvested fibroblasts. In addition, using a well annotated tumor micro array, we specifically demonstrate that stromal palladin and α-SMA expression levels correlate to each other. Moreover, we observed that stromal palladin expression levels are indicative of poor outcomes in early non-metastatic RCCs. Here we not only introduce an in vitro 3-D stroma system which accurately mimics the in vivo features of human RCC-associated stroma, but we demonstrate a clinical relevance to assessing stromal activation in human pathological RCC samples. Results from this study underscore a distinctive clinical relevance to assessing stromal progression in renal cell carcinomas. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3171. doi:10.1158/1538-7445.AM2011-3171
Preparation and Activities of Macromolecule Conjugates of the CCR5 Antagonist Maraviroc (2013)

CCR5 antagonists are among the most advanced approaches in HIV therapy and may also be relevant to treatment of graft-versus-host disease and <i>Staphylococcus aureus</i> infection. To expand the potential of the only approved CCR5 antagonist, Maraviroc, we studied derivatives that would enable functional linkage of Maraviroc to long-lived carriers. Through targeted synthesis, we discovered an effective linkage site on Maraviroc and demonstrate the potential of these derivatives to prepare potent chemically programmed antibodies and PEGylated derivatives. The resulting compounds effectively neutralized a variety of HIV-1 isolates. Both chemically programmed antibody and PEGylation approaches extend the neutralization activity of serum circulating Maraviroc. Derivation of a successful conjugation strategy for Maraviroc should further enable its use in chemically programmed vaccines, novel bispecific antibodies, and topical microbicides.
65‐1: Invited Paper : Characterizing High Dynamic Range Display System Properties in the Context of Today's Flexible Ecosystems (2016)

The transition from standard dynamic range (SDR) imaging systems whose characteristics were largely derived from the capabilities of CRT displays is well underway toward a newer ecosystem with higher capabilities. The newer ecosystem improves color volume aspects such as high dynamic range (HDR) and wide color gamut (WCG), as well as improvements in other dimensions such as bit‐depth, spatial resolution, energy, thermal management, field‐of‐view, mobility, and frame rate. More importantly, since there will not be one single predominating display technology, a large variability of color volumes will result. Thus, the newer ecosystem needs to tailor the imagery to the specific display. Achieving such an ecosystem that includes flexible delivery methods such as the internet, broadcast, and solid‐state memory‐based storage media, displays must be characterized much more completely than they have for previous broadcast and disc‐based storage media ecosystems standards. This paper focuses on the color volume aspects (HDR, WCG) of such needed characterization, as well as key spatial aspects that relate to modern single and dual modulation display technology and power saving.
Protective effect of diphlorethohydroxycarmalol against oxidative stress-induced DNA damage and apoptosis in retinal pigment epithelial cells (2019)

<b>Purpose:</b> Reactive oxygen species (ROS) contribute to the onset and progression of disease pathogenesis in a variety of organs, including age-related macular degeneration (AMD). Diphlorethohydroxycarmalol (DPHC), a phlorotannin compound, is one of the major components of the brown alga <i>Ishige okamurae</i> Yendo, and has been shown to have strong antioxidant capacity. The purpose of this study was to evaluate the protective effects of DPHC against oxidative stress (hydrogen peroxide, H<sub>2</sub>O<sub>2</sub>)-induced DNA damage and apoptosis in cultured ARPE19 retinal pigment epithelial (RPE) cells. <b>Materials and methods:</b> Cell viability was assessed by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide assay. Intracellular ROS generation was measured by flow cytometer using 2',7'-dichlorofluorescin diacetate. The magnitude of apoptosis was measured by flow cytometry using the annexin V/propidium iodide double staining. DNA damage was evaluated by DNA fragmentation assay, comet assay and 8-hydroxy-2'-deoxyguanosine (8-OHdG) analysis. To observe the mitochondrial membrane potential, 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethyl-imidacarbocyanine iodide staining was performed. In order to identify the underling mechanism of DPHC against H<sub>2</sub>O<sub>2</sub>-induced cellular alteration, we performed immune blotting. <b>Results:</b> The results of this study showed that the decreased survival rate brought about by H<sub>2</sub>O<sub>2</sub> could be attributed to the induction of DNA damage and apoptosis accompanied by the increased production of ROS, which was remarkably reversed by DPHC. In addition, the loss of H<sub>2</sub>O<sub>2</sub>-induced mitochondrial membrane potential was significantly attenuated in the presence of DPHC. The inhibitory effect of DPHC on H<sub>2</sub>O<sub>2</sub>-induced apoptosis was associated with a reduced Bax/Bcl-2 ratio, the protection of the activation of caspase-9 and -3 and the inhibition of poly (ADP-ribose) polymerase cleavage, which was associated with the blockage of cytochrome <i>c</i> release to the cytoplasm. <b>Conclusions:</b> Our data proved that DPHC protects ARPE19 cells against H<sub>2</sub>O<sub>2</sub>-induced DNA damage and apoptosis by scavenging ROS and thus suppressing the mitochondrial-dependent apoptosis pathway. Therefore, this study suggests that DPHC has the therapeutic potential to prevent AMD by inhibiting oxidative stress-induced injury in RPE cells.
Pharmacokinetics of isepamicin. (1995)

Isepamicin is a new aminoglycoside that has activity against many bacteria resistant to other aminoglycosides. The pharmacokinetics of isepamicin have been characterized in neonatal, pediatric, adult, elderly and renally impaired human populations as well as in clinical trials using the techniques of population pharmacokinetics. The pharmacokinetics of isepamicin are uncomplicated and generally similar to those of other aminoglycosides, although there is some evidence that it may have less tissue accumulation. The drug is completely absorbed following intramuscular administration. The drug is not metabolized and unchanged isepamicin accounts for all of the drug substance in plasma and urine. It is completely eliminated via the renal route; consequently dosing in patients with renal insufficiency has to be adjusted according to the degree of renal impairment. The pharmacokinetics of isepamicin are generally linear. Thus peak plasma concentrations and area under the plasma concentration curve (AUC) values are proportional to the administered dose while clearance (1.1-1.3 mL/min/kg), volume of distribution at steady state (0.23-0.29 L/kg) and half-life (2-2.5 h) are independent of dose. There is no significant accumulation of drug in the plasma with once- or twice-daily dosing. The isepamicin plasma concentration curve following a 1 g intravenous dose to healthy volunteers can be best characterized by a tri-exponential curve corresponding to a t1/2 alpha of 0.17 h, a t1/2 beta of 2.1 h, and a gamma-phase of 34 h. The t1/2 beta represents the elimination phase and changes with age and renal functions, while the gamma-phase represents the return of drug to plasma from a deep compartment including binding in renal tissue. The gamma-phase represents less than 3% of the total AUC and does not change with age. Isepamicin readily distributes to extracellular fluid and pulmonary tissue. In conclusion, isepamicin demonstrates predictable linear kinetics and is similar pharmacokinetically to other aminoglycosides. Preliminary indications of decreased tissue accumulation implied from pharmacokinetic and pharmacodynamic characteristics of isepamicin favour once-daily dosing.
Simultaneous balancing of geometric transformation and linear polarizations using six-fold-mirror geometry over the visible region (2020)

The presence of optical rotation due to the Berry phase and coating-induced linear polarizations across a set of rays deteriorate the form of a point spread function. In this Letter, we model an optical system with six aluminum coated fold mirrors, and we show how to balance geometric transformation, linear retardance, and linear diattenuation simultaneously. We minimize the linear polarizations by arranging the six fold mirrors in three pairs of crossed-fold-mirror geometry. In the same optical model, we also show that geometric transformation induced by the first set of three mirrors is canceled out by the second set of three mirrors by rotating the eigen-polarizations in opposite direction with the same amount. We perform experimental verification using a spectroscopic Mueller matrix polarimeter over the visible spectral range.
Coupled photonic crystal microcavities for optical switching over wide spectral range (2015)

A compact thermo-optic switch comprising a 3.78μm-long coupled photonic crystal resonators coupled to a photonic crystal waveguide is demonstrated with 6nm optical bandwidth, 20dB optical extinction ratio, 18.2mW switching power, and 14.8μsec rise time.
Recombinant Bacteriophage LysKB317 Endolysin Mitigates Lactobacillus Infection of Corn Mash Fermentations (2020)

Abstract Background Commercial ethanol fermentation facilities traditionally rely on antibiotics for bacterial contamination control. Here we demonstrate an alternative approach to treat contamination using a novel peptidoglycan hydrolase (LysKB317) isolated from a bacteriophage, EcoSau. This endolysin was specially selected against Lactobacillus strains that were isolated as contaminants from a fuel ethanol plant. The LysKB317 gene was recombinantly expressed in Escherichia coli as a 33 kDa purified enzyme. Results In turbidity reduction assays, the recombinant enzyme was subjected to a panel of 32 bacterial strains and was active against 28 bacterial strains representing one species of Acetobacter , eight species of Lactobacillus , one species of Pediococcus , three species of Streptococcus , and one species of Weissella . The activity of LysKB317 was optimal around pH 6, but it has broad activity and stability from pH 4.5 – 7.5 up to at least 48 h. Maximum activity was observed at 50°C up to at least 72 hrs. In addition, LysKB317 was stable in 30% ethanol up to at least 72 hrs. In experimentally infected corn mash fermentations, 1 µM endolysin reduced bacterial load by 3-log fold change, while 0.01 µM reduced bacteria by 2-log fold change. Concentration of fermentation products (ethanol, residual glucose, lactic acid, and acetic acids) for infected cultures treated with ≥ 0.01 µM LysKB317 were similar to uncontaminated controls. Conclusion Exogenously added LysKB317 endolysin is functional in conditions typically found in fuel ethanol fermentations tanks and may be developed as an alternative to antibiotics for contamination control during fuel ethanol fermentations.
ASSIGNMENT OF THE GENE FOR NEUTRAL ALPHA-GLUCOSIDASE-AB TO CHROMOSOME-11 (1982)

Human tissues contain two isozymes of neutral a-glucosidase, neutral a-glucosidase AB and neutral a-glucosidase C (a-D-glucoside glucohydrolase, EC 3.2.1.20). The two isozymes, initially defined on the basis of differences in electrophoretic mobility in starch gel, have also been shown to have other distinguishing biochemical characteristics including different substrate specificites. Rodent tissues contain apparently homologous isozymes of neutral a-glucosidase. The mouse and human a-glucosidase C isozymes, but not the AB isozyme(s), can be distinguished by the difference in their electrophoretic mobility. This difference has previously enabled us to use human-mouse somatic cell hybrids to assign the structural gene for human a-glucosidase C to chromosome 15. We now report the differentiation of mouse and human neutral a-glucosidase AB isozymes by rocket immunoelectrophoresis, using an antibody raised in mice against purified human placental neutral a-glucosidase AB. This antibody precipitated both the A and B bands of human neutral a-glucosidase AB and did not cross react with mouse enzyme as determined by Ouchterlony double immunodiffusion and by rocket immunoelectrophoresis. Using this antibody, the segregation of human neutral a-glucosidase AB was examined in 41 mouse x human hybrid clones. Thirty-eight hybrid clones, derived from fusions of RAG x seven different human cells, showed 100% concordant segregation of human neutral a-glucosidase AB and the 11. Three additional clones, derived from a fusion of tetraploid murine erythroleukemia cells (2S-MEL) x diploid human fibroblasts carrying a translocation chromosome(s) allowed the regional localization of the gene to the long arm of 11 (11q13→11qter).