gebhart/patrepeval huggingface dataset:
α1-Syntrophin Modulates Turnover of ABCA1 (2004)

ABCA1 (ATP-binding cassette transporter A1) mediates the release of cellular cholesterol and phospholipid to form high density lipoprotein. Functions of ABCA1 are highly regulated at the transcriptional and post-transcriptional levels, and the synthesized ABCA1 protein turns over rapidly with a half-life of 1-2 h. To examine whether the functions of ABCA1 are modulated by associated proteins, a yeast two-hybrid library was screened with the C-terminal 120 amino acids of ABCA1. Two PDZ (PSD95-Discs large-ZO1) proteins, alpha1-syntrophin and Lin7, were found to interact with ABCA1. Immunoprecipitation revealed that alpha1-syntrophin interacted with ABCA1 strongly and that the interaction was via the C-terminal three amino acids SYV of ABCA1. Co-expression of alpha1-syntrophin in human embryonic kidney 293 cells retarded degradation of ABCA1 and made the half-life of ABCA1 five times longer than in the cells not expressing alpha1-syntrophin. This effect is not common among PDZ-containing proteins interacting with ABCA1, because Lin7, which was also found to interact with the C terminus region of ABCA1, did not have a significant effect on the half-life of ABCA1. Co-expression of alpha1-syntrophin significantly increased the apoA-I-mediated release of cholesterol. ABCA1 was co-immunoprecipitated with alpha1-syntrophin from mouse brain. These results suggest that alpha1-syntrophin is involved in intracellular signaling, which determines the stability of ABCA1 and modulates cellular cholesterol release.
Immunoreaction at 43 kDa with Anti‐ubiquitin Antibody in Breast Neoplasms (1997)

Protein ubiquitination has been implicated in ATP-dependent protein turnover and normal cell proliferation. To investigate whether the ubiquitin-mediated system is functionally involved in the cancerous state, we examined changes in protein ubiquitination in 52 surgically resected primary breast tumors. Immunohistochemically, ubiquitin (Ub) was identified in the cytoplasm of cancer cells, which were stained more strongly than adjacent normal ductal epithelium. Corresponding immunoblot analysis of normal and neoplastic regions of human breast showed that the immunoreaction for Ub at about 43 kDa was increased in all of the tumors (100%), regardless of the clinical stage or histologic grade. This protein, which gave a single spot on two-dimensional gel electrophoresis, had partial amino acid sequences which were identical to those of actin family members. Our results suggest that ubiquitination of this 43-kDa protein may be involved in the carcinogenesis or biological characteristics of human breast neoplasms.
Experimental Investigation and Analysis of the Operation Characteristics of a Planar Cs-Ba Tacitron (1994)

Tests are performed which focused on characterizing the operation capabilities of a planar Cs‐Ba tacitron. Results show the forward voltage drop decreases as either the grid‐collector (GC) gap size and/or the Cs pressure increases. Results also show that stable current modulation is easier to obtain when the grid is placed closer to the collector, at the expense of increasing the forward voltage drop in the device.
The host defense peptide LL‐37 activates the tumor‐suppressing bone morphogenetic protein signaling via inhibition of proteasome in gastric cancer cells (2010)

The human cathelicidin LL-37, a pleiotropic host defense peptide, is down-regulated in gastric adenocarcinomas. We therefore investigated whether this peptide suppresses gastric cancer growth. LL-37 lowered gastric cancer cell proliferation and delayed G(1)-S transition in vitro and inhibits the growth of gastric cancer xenograft in vivo. In this connection, LL-37 increased the tumor-suppressing bone morphogenetic protein (BMP) signaling, manifested as an increase in BMP4 expression and the subsequent Smad1/5 phosphorylation and the induction of p21(Waf1/Cip1). The anti-mitogenic effect, Smad1/5 phosphorylation, and p21(Waf1/Cip1) up-regulation induced by LL-37 were reversed by the knockdown of BMP receptor II. The activation of BMP signaling was paralleled by the inhibition of chymotrypsin-like and caspase-like activity of proteasome. In this regard, proteasome inhibitor MG-132 mimicked the effect of LL-37 by up-regulating BMP4 expression and Smad1/5 phosphorylation. Further analysis of clinical samples revealed that LL-37 and p21(Waf1/Cip1) mRNA expressions were both down-regulated in gastric cancer tissues and their expressions were positively correlated. Collectively, we describe for the first time that LL-37 inhibits gastric cancer cell proliferation through activation of BMP signaling via a proteasome-dependent mechanism. This unique biological activity may open up novel therapeutic avenue for the treatment of gastric cancer.
Evidence of autocrine modulation of macrophage nitric oxide synthase by alpha-melanocyte-stimulating hormone. (1995)

alpha-Melanocyte-stimulating hormone (alpha-MSH) is a potent inhibitory agent in all major forms of inflammation. To identify a potential mechanism of antiinflammatory action of alpha-MSH, we tested its effects on production of nitric oxide (NO), believed to be a mediator common to all forms of inflammation. We measured NO and alpha-MSH production in RAW 264.7 cultured murine macrophages stimulated with bacterial lipopolysaccharide and interferon gamma. alpha-MSH inhibited production of NO, as estimated from nitrite production and nitration of endogenous macrophage proteins. This occurred through inhibition of production of NO synthase II protein; steady-state NO synthase II mRNA abundance was also reduced. alpha-MSH increased cAMP accumulation in RAW cells, characteristic of alpha-MSH receptors in other cell types. RAW cells also expressed mRNA for the primary alpha-MSH receptor (melanocortin 1). mRNA for proopiomelanocortin, the precursor molecular of alpha-MSH, was expressed in RAW cells, and tumor necrosis factor alpha increased production and release of alpha-MSH. These results suggest that the proinflammatory cytokine tumor necrosis factor alpha can induce macrophages to increase production of alpha-MSH, which then becomes available to act upon melanocortin receptors on the same cells. Such stimulation of melanocortin receptors could modulate inflammation by inhibiting the production of NO. The results suggest that alpha-MSH is an autocrine factor in macrophages which modulates inflammation by counteracting the effects of proinflammatory cytokines.
Bi‐ und tricyclische Ergolinanaloge mit dopaminergen Eigenschaften (1994)

Abstract Zur Förderung des wissenschaftlichen Nachwuchses – speziell zur Anerkennung überdurchschnittlicher Habilitationen – im Bereich der Pharmazie vergibt die Deutsche Pharmazeutische Gesellschaft bis zu einmal jährlich den mit 10 000 DM dotierten Johann‐Wolfgang‐Döbereiner Preis (früher Carl‐Mannisch‐Stipendium). Erst kürzlich wurde der Preis für 1994 erneut ausgeschrieben (s. Pharmazie in unserer Zeit Heft 1/94). Mit der Annahme verpflichtet sich der jeweilige Preisträger, in einem für die wissenschaftliche Öffentlichkeit allgemein verständlichen Übersichtsartikel über seine Forschungsergebnisse zu berichten. Preisträger im vergangenen Jahr war Privatdozent Dr. P. Gmeiner (München) , der inzwischen einen Ruf auf eine C‐3‐Professur an der Universität Bonn angenommen hat und der hier über wesentliche Aspekte seiner ausgezeichneten Habilitationsschrift berichtet.
PbTiO3Nanoparticles Embedded in a Liquid Crystalline Elastomer Matrix: Structural and Ordering Properties (2010)

Ferroelectric PbTiO3 nanoparticles were synthesized to be used as inorganic components of new composite materials based on a liquid crystalline elastomer (LCE) matrix. The preparation and characterization of the composite materials, with a relatively high concentration of PbTiO3 nanoparticles, in the form of thin films is described. The composite films retain the thermomechanical response typical of standard LCEs and the nanoparticles are distributed in the film in anisotropic structures indicating the presence of a coupling between the LCE ordered matrix and the nanomaterials. The nematoelastic coupling and the supercritical nature of the paranematic−nematic transition of the LSCE-based composites was verified also in the presence of ferroelectric nanoparticles.
Aural-Based Detection and Assessment of Real Versus Artificially Synchronized String Quartet Performance (2013)

Comunicació presentada a: the 3rd International Conference on Music &amp; Emotion (ICME3), celebrada a Jyväskylä, Finlàndia, de l'11 al 15 de juny de 2013.
A self-aligned stacked capacitor using novel Pt electroplating method for 1 Gbit DRAMs and beyond (1999)

We first developed a novel self-aligned electroplating process to fabricate Pt electrodes for integrated high-dielectric capacitors. Electroplated Pt filled 120 nm-wide buried contact (BC) holes (aspect ratio 2:1). Pt pillars of 210 nm diameter and 650 nm height were successfully fabricated. The leakage current density of sputtered BST capacitors using electroplated bottom Pt was less than 200 nA/cm/sup 2/ at /spl plusmn/1.5 V. The oxide-equivalent thickness T/sub oxeq/ and dissipation factor of 40 nm-thick BST films were 0.70 nm and 0.0080 at 0 V, respectively.
Influence of modulation instability on distributed optical fiber sensors based on spontaneous Brillouin scattering (2004)

The performance of distributed fiber sensors based on spontaneous Brillouin scattering is largely determined by the peak power governed by nonlinear thresholds that can be launched into the sensing fiber. Our investigations show that, in long-range (&gt;20-km) sensors that use a standard single-mode fiber operating at 1.5 μm, modulation instability can limit the acceptable pulse power to below 100 mW. Using a nonzero dispersion-shifted fiber with negative dispersion we can avoid this problem and obtain a ninefold increase in launched power.
Using Social Information for Flow Allocation in MANETs (2013)

Adhoc networks enable communication between distributed, mobile wireless nodes without any supporting infrastructure. In the absence of centralized control, such networks require node interaction, and are inherently based on cooperation between nodes. In this paper, we use social and behavioral trust of nodes to form a flow allocation optimization problem. We initialize trust using information gained from users' social relationships (from social networks) and update the trusts metric over time based on observed node behaviors. We conduct analysis of social trust using real data sets and used it as a parameter for performance evaluation of our frame work in ns-3. Based on our approach we obtain a significant improvement in both detection rate and packet delivery ratio using social trust information when compared to behavioral trust alone. Further, we observe that social trust is critical in the event of mobility and plays a crucial role in bootstrapping the computation of trust.
Fast Frequency Control Scheme through Adaptive Virtual Inertia Emulation (2018)

This paper presents a novel virtual inertia controller for converters in power systems with high share of renewable resources. By combining the analytical study of system dynamics and a Linear-Quadratic Regulator (LQR)-based optimization technique, the optimal state feedback gain is determined, adapting the emulated inertia constant according to the frequency disturbance in the system. The optimality is achieved through trade-off between the critical frequency limits and the required control effort, i.e. utilization of the internal energy storage. The proposed controller is integrated into a state-of-the-art converter control scheme and verified through EMT simulations. The results show a significant improvement in the frequency response compared to an open-loop system, while also preserving drastically more DC-side energy than a non-adaptive controller.
Biomechanical properties of carbodiimide crosslinked collagen: Influence of the formation of ester crosslinks (2007)

There is a growing interest in the use of collagen matrices for tissue engineering. To prevent rapid degradation and to improve their mechanical properties, collagen matrices have been modified using different crosslinking agents. Among the different agents used, water soluble carbodiimides (such as N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide, EDC) in combination with N-hydroxysuccinimide (NHS) are attractive systems, because no additional chemical entities are incorporated in the matrix. EDC/NHS crosslinking leads to amide bond formation between activated carboxyl groups and amine groups. Recently, we proposed that in addition to amide bond formation, ester links are also formed between activated carboxyl groups and hydroxyl groups. This was based on observations we made after development of a new method to quantify concentrations of carboxyl groups of collagen materials before and after crosslinking. The current study is directed to the influence of ester bond crosslinks formed after crosslinking of collagen with EDC/NHS on its physical-chemical and biomechanical properties. Reconstituted dermal bovine collagen patches (RDBC) were used as model material and were crosslinked with EDC/NHS. In one RDBC group, collagen amine groups were blocked with propionaldehyde prior to crosslinking, while in the other group unprocessed RDBC was crosslinked without additional matrix modifications. It was shown that after activation of collagen carboxyl groups with EDC and NHS, amide crosslinks as well as ester crosslinks with collagen hydroxyl groups were formed. It was furthermore demonstrated that the ester crosslinks of EDC/NHS-crosslinked RDBC could be removed by mild hydrolysis affording collagen matrices with improved mechanical properties.
Gilbert Syndrome Contradictions (2017)

Introduction: Gilbert's syndrome is considered to be entirely benign. Some studies have shown a reduced risk for cardiovascular disease (CVD). There is conflicting data regarding cancer risk among these patients. Aim: To evaluate the association of Gilbert syndrome with CVD and cancer. RESULTS and Methods: Clinical and epidemiological data were obtained from healthy subjects undergoing annual screening at the Integrated Cancer Prevention Center in Tel Aviv.A total of 6258 (49%) men and 6461 (51%) women mean age 47.0±11.5 years were included of which 1,019 had clinical gilbert. Gilbert was significantly more common among men (11.5% versus 4.6% P. Conclusion: In a large cohort it seems to be associated with increased risk for hypertension, CVD and CVA with shorter life-span observed in these patients. Urinary cancer is higher but females are protected from breast cancer. Further studies needed to better understand these findings and determine proper screening and surveillance practices in Gilbert disease.
Cobalt(III)-Catalyzed Living Polymerization of Ethylene: Routes to End-Capped Polyethylene with a Narrow Molar Mass Distribution (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCobalt(III)-Catalyzed Living Polymerization of Ethylene: Routes to End-Capped Polyethylene with a Narrow Molar Mass DistributionM. Brookhart, J. M. DeSimone, B. E. Grant, and M. J. TannerCite this: Macromolecules 1995, 28, 15, 5378–5380Publication Date (Print):July 1, 1995Publication History Published online1 May 2002Published inissue 1 July 1995https://doi.org/10.1021/ma00119a033RIGHTS & PERMISSIONSArticle Views638Altmetric-Citations99LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (331 KB) Get e-AlertsSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Bovine Serum Albumin Glutaraldehyde for Completely Sutureless Laparoscopic Heminephrectomy in a Survival Porcine Model (2010)

BSAG for completely sutureless LPN in a survival porcine model was feasible.
ATRT-06. SMARCB1 LOSS DRIVEN NON-CANONICAL PRC1 ACTIVITY REGULATES DIFFERENTIATION IN ATYPICAL TERATOID RHABDOID TUMORS (ATRT) (2020)

Abstract Loss of SMARCB1 is the hallmark genetic event that characterizes ATRT. SMARCB1 is a member of the SWI/SNF chromatin remodeling complex that is responsible for determining cellular pluripotency and lineage commitment. To identify co-operating epigenetic factors, we performed an unbiased shRNA screen targeting 408 epigenetic/chromatin molecules in patient-derived ATRT cell lines and identified BMI1, a component of the Polycomb Repressive Complex 1 (PRC1), as essential for ATRT cell viability. Genetic and Chemical inhibition of BMI1 inhibited clonogenic potential and induced apoptosis in vitro. In vivo PTC 596 significantly decreased growth of intracranial orthotopic ATRT tumors as evaluated by T2 MRI imaging and significantly prolonged survival compared to control animals. Using RNA-seq and ChIP-Seq our studies show that BMI1 co-operates with SMARCB1 loss to suppress transcription of pro-differentiation pathways and promote self-renewal of tumor stem cells. We then used a doxycycline-inducible SMARCB1 expression system and performed Immunoprecipitation for BMI1, followed by and mass spectrometry analysis. In SMARCB1 deficient cells BMI1 forms a partial PRC1 complex devoid of DNA binding components. Re-expression of SMARCB1 activates two PRC1 chromatin localizing components CBX4 and CBX8. CBX4 is implicated DNA damage response, tumor angiogenesis and self-renewal. CBX8 activates lineage-specific genes during differentiation of ESC. Our data suggest that SMARCB1 deletion results in reprograming of BMI1 chromatin occupancy away from lineage specification by altering the components of the PRC1 complex. These studies identify the mechanistic basis of BMI1 co-operation with SMARCB1 loss in ATRT and establish BMI1 inhibition as a novel therapeutic approach in ATRT.
FPGA clock network architecture (2006)

This paper examines the tradeoffs between flexibility, area, and power dissipation of programmable clock networks for Field-Programmable Gate Arrays (FPGA's). The paper begins by describing a parameterized clock network model that describes a broad range of programmable clock network architectures. Specifically, the model supports architectures with multiple local and global clock domains and varying amounts of flexibility at various levels of the clock network. Using the model, the architectural parameters that control the flexibility of the clock network are varied to determine the cost of this flexibility in terms of area and power dissipation. From these experiments, the study finds that area and power costs are highest for networks with flexibility close to the logic blocks. Furthermore, it found that clock networks with local clock domains have little overhead and are significantly more efficient than clock networks without local clock domains for applications with multiple clocks.
Electronic thermal properties of the interface between a normal metal and a high-temperature superconducting material (2000)

The electron thermal flux and electron thermal conductivity of the interface between a normal metal and a high-temperature superconductor (HTSC) are calculated using quasiclassical equations. Calculations are made for various values of the interface transparency and various orientations of the axes of a HTSC crystal. It was shown that compared with an interface between a normal metal and an “ordinary” superconductor (s-type symmetry, isotropic order parameter), the thermal conductivity of an HTSC-normal-metal interface is substantially higher and has a nonactivation dependence. The thermal properties were calculated for various interface models, including mirror and diffuse, and also for various potential barrier profiles. An analysis is made of the possibility of using devices based on normal-metal-HTSC interfaces for bolometric and microrefrigerator applications.
Quantum Chemical Approach to Estimating the Thermodynamics of Metabolic Reactions (2014)

Thermodynamics plays an increasingly important role in modeling and engineering metabolism. We present the first nonempirical computational method for estimating standard Gibbs reaction energies of metabolic reactions based on quantum chemistry, which can help fill in the gaps in the existing thermodynamic data. When applied to a test set of reactions from core metabolism, the quantum chemical approach is comparable in accuracy to group contribution methods for isomerization and group transfer reactions and for reactions not including multiply charged anions. The errors in standard Gibbs reaction energy estimates are correlated with the charges of the participating molecules. The quantum chemical approach is amenable to systematic improvements and holds potential for providing thermodynamic data for all of metabolism.
Robotic catheter cardiac ablation combining ultrasound guidance and force control (2014)

Cardiac catheters allow physicians to access the inside of the heart and perform therapeutic interventions without stopping the heart or opening the chest. However, conventional manual and actuated cardiac catheters are currently unable to precisely track and manipulate the intracardiac tissue structures because of the fast tissue motion and potential for applying damaging forces. This paper addresses these challenges by proposing and implementing a robotic catheter system that uses 3D ultrasound image guidance and force control to enable constant contact with a moving target surface in order to perform interventional procedures, such as intracardiac tissue ablation. The robotic catheter system, consisting of a catheter module, ablation and force sensing end effector, drive system, and image-guidance and control system, was commanded to apply a constant force against a moving target using a position-modulated force control method. The control system uses a combination of position tracking, force feedback, and friction and backlash compensation to achieve accurate and safe catheter–tissue interactions. The catheter was able to maintain a 1 N force on a moving motion simulator target under ultrasound guidance with 0.08 N RMS error. In a simulated ablation experiment, the robotic catheter was also able to apply a consistent force on the target while maintaining ablation electrode contact with 97% less RMS contact resistance variation than a passive mechanical equivalent. In addition, the use of force control improved catheter motion tracking by approximately 20%. These results demonstrate that 3D ultrasound guidance and force tracking allow the robotic system to maintain improved contact with a moving tissue structure, thus allowing for more accurate and repeatable cardiac procedures.