gebhart/patrepeval huggingface dataset:
Data from <i>Seizure 6-Like</i> (<i>SEZ6L</i>) Gene and Risk for Lung Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;DNA pooling in combination with high-throughput sequencing was done as a part of the Sequenom-Genefinder project. In the pilot study, we tested 83,715 single nucleotide polymorphisms (SNP), located primarily in gene-based regions, to identify polymorphic susceptibility variants for lung cancer. For this pilot study, 369 male cases and 287 controls of both sexes (white Europeans of Southern German origin) were analyzed. The study identified a candidate region in 22q12.2 that contained numerous SNPs showing significant case-control differences and that coincides with a region that was shown previously to be frequently deleted in lung cancer cell lines. The candidate region overlies the &lt;i&gt;seizure 6-like&lt;/i&gt; (&lt;i&gt;SEZ6L&lt;/i&gt;) gene. The pilot study identified a polymorphic Met430Ile substitution in the &lt;i&gt;SEZ6L&lt;/i&gt; gene (SNP rs663048) as the top candidate for a variant modulating risk of lung cancer. Two replication studies were conducted to assess the association of SNP rs663048 with lung cancer risk. The M. D. Anderson Cancer Center study included 289 cases and 291 controls matched for gender, age, and smoking status. The Liverpool Lung Project (a United Kingdom study) included 248 cases and 233 controls. Both replication studies showed an association of the rs663048 with lung cancer risk. The homozygotes for the variant allele had more than a 3-fold risk compared with the wild-type homozygotes [combined odds ratio (OR), 3.32; 95% confidence interval (95% CI), 1.81–7.21]. Heterozygotes also had a significantly elevated risk of lung cancer from the combined replication studies with an OR of 1.15 (95% CI, 1.04–1.59). The effect remained significant after adjusting for age, gender, and pack-years of tobacco smoke. We also compared expression of &lt;i&gt;SEZ6L&lt;/i&gt; in normal human bronchial epithelial cells (&lt;i&gt;n&lt;/i&gt; = 7), non–small cell lung cancer (NSCLC; &lt;i&gt;n&lt;/i&gt; = 52), and small cell lung cancer (SCLC; &lt;i&gt;n&lt;/i&gt; = 22) cell lines by using Affymetrix HG-U133A and HG-U133B GeneChips. We found that the average expression level of &lt;i&gt;SEZ6L&lt;/i&gt; in NSCLC cell lines was almost two times higher and in SCLC cell lines more than six times higher when compared with normal lung epithelial cell lines. Using the National Center for Biotechnology Information Gene Expression Omnibus database, we found a ∼2-fold elevated and statistically significant (&lt;i&gt;P&lt;/i&gt; = 0.004) level of SEZ6L expression in tumor samples compared with normal lung tissues. In conclusion, the results of these studies representing 906 cases compared with 811 controls indicate a role of the &lt;i&gt;SEZ6L&lt;/i&gt; Met430Ile polymorphic variant in increasing lung cancer risk. [Cancer Res 2007;67(17):8406–11]&lt;/p&gt;&lt;/div&gt;
Well-Dispersed Suspension Formation for Infiltration of Ceramic Fiber Preforms With SiC-Filled Polysiloxane Resins (1997)

Abstract The development of low-viscosity preceramic polymers such as Blackglas™1, introduced new opportunities to the processing of ceramic-ceramic composites. Many polymer based liquid processing technologies that have been vastly investigated and established, can now be applied to ceramic composite processing with preceramic polymers. Resin transfer molding (RTM) is one of the most promising techniques adaptable to manufacturing of continuous fiber reinforced, ceramic composite structures with reliable, cost-effective properties. A major drawback of the process is the material loss in the preceramic polymer during processing, resulting in a porous structure that needs to be densified for satisfactory structural performance. This can be accomplished through several process cycles at the expense of cost-effectiveness. One way of reducing the number of cycles and obtaining near-net shapes during the process is the inclusion of inert and/or active filler particles in the polymer during injection.
Adenine Arabinoside 5′–Monophosphate Treatment of Chronic Type B Hepatitis (1982)

Six patients with chronic type B hepatitis were treated with adenine arabinoside 5'-monophosphate at a dosage of 10 to 15 mg per kg per day for 10 days. All demonstrated an immediate and marked decrease in serum hepatitis B virus DNA and DNA polymerase, and 5 of the 6 became negative for both markers by the end of the period of therapy. One patient remained negative for hepatitis B virus DNA and DNA polymerase when therapy was discontinued. This patient subsequently exhibited clinical, serum biochemical, and histological remission in disease activity concurrent with seroconversion from hepatitis B e antigen to antibody. In the remaining five patients, serum hepatitis B virus DNA and DNA polymerase returned to pretreatment values soon after therapy was stopped, and these patients demonstrated no significant changes in clinical, biochemical, serological, or histological features of the disease. Side effects of the therapy were mild and transient. These results suggest that a 10-day course of adenine arabinoside 5'-monophosphate is not adequate to induce permanent amelioration of infection and disease activity in the majority of patients with chronic type B hepatitis.
Detection and reconstruction of human scale features from high resolution interferometric SAR data (2002)

In contrast to optical imagery, modern high resolution IFSAR sensors deliver intensity images and corresponding interferometric height and coherence data from a single flight path at pixel sizes of 30 cm to 10 cm. Due to the all-weather, day-night applicability of SAR sensors, multiple views over short time can be easily obtained. However, many image users find it difficult to "read" radar images. They differ from the natural human visual impression and the familiar analogy communicated by optical imagery. The goal of our work is to convert radar data into models of the terrain and render those models in analogy to the optical sensing approach that the human visual system represents. Therefore intelligent combinations of multiple views and measurements from all IFSAR data sources available are necessary to help to overcome problems inherent in the SAR data as e.g., blur, speckle, layover and shadow. Using basic image analysis methods we present in this paper our first fully automated approach to separate buildings from other objects in an IFSAR dataset. The building shapes are reconstructed using a simple building model and the results are compared to measurements made from optical imagery.
Application of HPLC and Dual Wavelength Detection to the Analysis of Phenolic Compounds in Apples (1988)

Abstract High-performance liquid chromatography, coupled with a programmable UV/visible detector, was applied to the identification and quantification of the phenolic compounds of apple tissue. The identity and purity of unknown components eluted from the HPLC column were established by comparing retention times and absorbance ratios with those of authentic compounds. In Golden Delicious apples, components with retention times agreeing with those of authentic catechin, epicatechin, chlorogenic acid, protocatechuic acid, p-hydroxybenzoic acid, p-coumaric acid, ferulic acid, and sinapic acid were found. However, comparison of absorbance ratios with those of authentic compounds suggested that many of the components that eluted in this system as single, symmetrical peaks were mixtures rather than individual compounds. This method helped to eliminate inaccurate identifications or faulty assumptions about homogeneity of HPLC “peaks”, errors that can occur when traditional HPLC methods that rely solely on detection at a single wavelength are employed. The method should have general applicability to plant extracts.
Cerebellar nuclei evolved by repeatedly duplicating a conserved cell type set (2020)

Abstract How have complex brains evolved from simple circuits? Here we investigated brain region evolution at cell type resolution in the cerebellar nuclei (CN), the output structures of the cerebellum. Using single-nucleus RNA sequencing in mice, chickens, and humans, as well as STARmap spatial transcriptomic analysis and whole-CNS projection tracing in mice, we identified a conserved cell type set containing two classes of region-specific excitatory neurons and three classes of region-invariant inhibitory neurons. This set constitutes an archetypal CN that was repeatedly duplicated to form new regions. Interestingly, the excitatory cell class that preferentially funnels information to lateral frontal cortices in mice becomes predominant in the massively expanded human Lateral CN. Our data provide the first characterization of CN transcriptomic cell types in three species and suggest a model of brain region evolution by duplication and divergence of entire cell type sets.
Throughput comparison of CSMA/CA and hybrid CSMA/CA-TDMA in IEEE 802.15.3c WPAN (2009)

This paper studies the system throughput of the 802.15.3c WPAN by considering the different wireless multiple access methods of CSMA/CA and hybrid CSMA/CA and TDMA. We construct an analytical model to study the throughput and the conducted analysis clearly shows the system throughput of the 802.15.3c WPAN upon both CSMA/CA and hybrid CSMA/CA and TDMA. We have found that CSMA/CA-TDMA can achieve much higher throughput compared to CSMA/CA, especially as the increase in the contending devices of a network.
Asymmetric Synthesis of γ-Amino Alcohols by Copper-Catalyzed Hydroamination (2019)

Asymmetric synthesis of γ-amino alcohols from unprotected allylic alcohols by a copper-catalyzed hydroamination strategy has been developed. Using easily accessible starting materials, a range of chiral 1,3-amino alcohols were prepared with excellent regio- and enantioselectivity. Further, this protocol provided an efficient one-step method for the enantioselective synthesis of γ-amino alcohols in an intermolecular manner.
Improved hydrogenation catalysts for coal-derived liquids (1994)

Benzene, naphthalene and biphenyl hydrogenation in a slurry-phase reactor were used as probe reactions to investigate the influence of bimetallic catalyst formulations and altervalent carrier doping on hydrogenation activity and sulphur-poisoning characteristics. It was found that addition of a secondary metal such as Pd, Ir or Re to primary metals such as Pt, Rh, or Ru, has a beneficial influence on these parameters. Significant enhancements in hydrogen adsorption capacity, hydrogenation activity and sulphur tolerance were observed when metals were dispersed on TiO2 doped with higher-valence cations. The enhancement factors were found to be a function of the dopant concentration in the carrier. Results related to altervalent carrier doping are explained in terms of long-range electronic interactions at the metal-support interface which alter the work function of surface metal atoms.
Drag-a-drop: a characterization tool for immersion lithography (2006)

In order to quickly and cheaply test candidate fluids and coatings for immersion lithography, we have devised a fluid handling scheme that we call drag-a-drop. We have constructed a prototype tool in order to test materials using this fluid scheme, and conducted several experiments with it. From these tests, we have determined that a hydrophobic topcoat with low contact angle hysteresis on the substrate increases the maximum stable scanning velocity by at least a factor of 2 over a standard 193 nm photoresist. We observed that instabilities on the receding contact line are unaffected by height, but the onset of instability on the advancing contact line occurs when the height of the lens is low. We also examined the drag-a-drop technique for possible use in laser mask writing, and found that by means of a hydrophobic topcoat, the lens can be completely removed from the substrate while keeping the immersion droplet affixed to the lens.
Bilateral Exudative Retinal Detachments and Panuveitis in a Patient with Multiple Myeloma (2023)

Extensive, bilateral exudative RD and panuveitis are rare but potentially sight-threatening findings in patients with MM.
Neuroleptic Malignant Syndrome (1986)

Sir: In their recent review ofthe neuroleptic malignant syndrome (NMS) Drs Abbott & Loizon (Journal, January 1986, 148, 47"51)recommended sodium dantrolene and bromocriptine as the best treatment options for this syndrome. We wish to suggest the possible use of electroconvulsive treatment (ECT) in NMS in addition to these treatment modalities.
Robust On-Chip Communication (2006)

The balance between computation and communication is a fundamental issue in application performance. As the chip industry gets entrenched in multicore architectures, this issue will become particularly and progressively important--not only in terms of chip-level performance, but also in terms of power, temperature, and reliability. Reliable communication is essential to overall computational robustness.
An Integrated In Vivo/In Vitro Protein Production Platform for Site-Specific Antibody Drug Conjugates (2023)

The XpressCF+<sup>®</sup> cell-free protein synthesis system is a robust platform for the production of non-natural amino acids containing antibodies, which enable the site-specific conjugation of homogeneous antibody drug conjugates (ADCs) via click chemistry. Here, we present a robust and scalable means of achieving a 50-100% increase in IgG titers by combining the high productivity of cell-based protein synthesis with the unique ability of XpressCF+<sup>®</sup> reactions to produce correctly folded and assembled IgGs containing multiple non-natural amino acids at defined positions. This hybrid technology involves the pre-expression of an IgG light-chain (LC) protein in a conventional recombinant <i>E. coli</i> expression system, engineered to have an oxidizing cytoplasm. The prefabricated LC subunit is then added as a reagent to the cell-free protein synthesis reaction. Prefabricated LC increases IgG titers primarily by reducing the protein synthesis burden per IgG since the cell free translation machinery is only responsible for synthesizing the HC protein. Titer increases were demonstrated in four IgG products in scales ranging from 100-µL microplate reactions to 0.25-L stirred tank bioreactors. Similar titer increases with prefabricated LC were also demonstrated for a bispecific antibody in the scFvFc-FabFc format, demonstrating the generality of this approach. Prefabricated LC also increases robustness in cell-free reactions since it eliminates the need to fine-tune the HC-to-LC plasmid ratio, a critical parameter influencing IgG assembly and quality when the two IgG subunits are co-expressed in a single reaction. ADCs produced using prefabricated LC were shown to be identical to IgGs produced in cell-free alone by comparing product quality, in vitro cell killing, and FcRn receptor binding assays. This approach represents a significant step towards improving IgG titers and the robustness of cell-free protein synthesis reactions by integrating in vivo and in vitro protein production platforms.
Room temperature molecular resolution nanopatterning of cyclopentene monolayers on Si(100) via feedback controlled lithography (2013)

Molecularly precise nanopatterning is demonstrated for a saturated organic monolayer on the Si(100) surface using room temperature ultra-high vacuum scanning tunneling microscopy. In particular, feedback controlled lithography enables the clean desorption of individual molecules from a highly-ordered cyclopentene monolayer at moderate negative sample bias, resulting in the exposure of isolated silicon dimers on an otherwise organically passivated surface. The quality and uniformity of the cyclopentene passivation layer is also quantified with X-ray photoelectron spectroscopy following exposure to ambient conditions, revealing that complete formation of the native oxide on silicon is suppressed for time scales exceeding 100 days.
A testbed for simulating electromagnetic effects on software execution (2017)

A simulation environment for studying the effects of electromagnetic perturbations on software execution is presented. We execute a program inside the processor and then we introduce glitches at different points in time and at different locations to modify the program execution. We manage to alter the state of a counter program by introducing glitches taking into account the target instruction and the timing diagram associated with it.
In pursuit of the “holy grail”: recombinant allergens and peptides as catalysts for the allergen‐specific immunotherapy (1995)

This presentation reviews recent progress in knowledge of (i) molecular biology and immunology of allergens and (ii) the methods for the modulation of allergen-specific immune response, with special emphasis on our grass pollen allergens, particularly Pao p IX AL, used as a model. The last few years have seen tremendous progress in molecular characterization of allergens, leading to synthesis of a number of recombinant allergens. Furthermore, studies of the structure-activity relationship of allergens have led to the delineation of the epitopes of these allergens and of widespread cross-reactivities among diverse allergens. In view of the requirement for extensive pre-clinical studies, the application of the recombinant allergens and epitopes in the clinical realm has just begun. Studies in murine systems suggest that these allergens and/or their epitopic peptides downregulate allergen-specific immune responses de novo. The potential and drawbacks of the recombinant allergens and peptides for improving the existing immunotherapeutic approaches and for developing new approaches to specific immunotherapy are discussed.
A functional genomics screen identifying blood cell development genes inDrosophilaby undergraduates participating in a course-based research experience (2021)

Undergraduate students participating in the UCLA Undergraduate Research Consortium for Functional Genomics (URCFG) have conducted a two-phased screen using RNA interference (RNAi) in combination with fluorescent reporter proteins to identify genes important for hematopoiesis in Drosophila. This screen disrupted the function of approximately 3500 genes and identified 137 candidate genes for which loss of function leads to observable changes in the hematopoietic development. Targeting RNAi to maturing, progenitor, and regulatory cell types identified key subsets that either limit or promote blood cell maturation. Bioinformatic analysis reveals gene enrichment in several previously uncharacterized areas, including RNA processing and export and vesicular trafficking. Lastly, the participation of students in this course-based undergraduate research experience (CURE) correlated with increased learning gains across several areas, as well as increased STEM retention, indicating that authentic, student-driven research in the form of a CURE represents an impactful and enriching pedagogical approach.
Dehydro-dermorphins. I. Influence of the stereo-orientation of aromatic groups in dermorphin-(1-5)-peptides to opioid activity. (1986)

Dehydrophenylalanine having the Z-configuration (delta Phe) and D-Phe were incorporated in positions 3 and/or 5 into dermorphin-(1-5)-peptide amide (H-Tyr-D-Ala-Phe-Gly-Tyr-NH2) in order to study the effect of structure or configurational changes. On GPI preparation, whereas the activity of [L-Phe5]-pentapeptide was fourfold higher than parent peptide and comparable to that of dermorphin, the substitution of Phe3 by its D-enantiomer was barely tolerated. The pentapeptides containing delta Phe in positions 3 and/or 5 displayed even lower potency: particularly the unsaturation at position 3 alone or at position 3 and 5 was very detrimental to mu activity.
An On-Chip Dynamically Obfuscated Wrapper for Protecting Supply Chain Against IP and IC Piracies (2018)

With the modern semiconductor supply chain, the ownership of both intellectual property (IP) and integrated circuit (IC) cannot be guaranteed. The IP piracy may take place at the untrusted IC designer or untrusted foundry without the knowledge of the original IP owner. The untrusted foundry can also perform IC piracy with reverse engineering of GDSII, overproducing the number of ICs, and shipping out-of-spec/defective devices. A holistic solution is proposed to protect the ownership of both IP owners and IC designers. In this solution, a dynamically obfuscated wrapper for split test (DOST) and a secure split test methodology together aim at preventing IP overusing at multiple abstraction levels and enabling IC designers to fully control the production, test, and authentication processes. DOST has been implemented and validated on video graphics array-liquid crystal display, floating-point and graphics unit, Leon3, and Leon3mp benchmarks. DOST enables the structural tests in the locked mode and the functional tests in the functionally unlocked mode. The results show that the proposed method is highly robust against IP and IC piracies with an insignificant area (1.381%) and power (1.276%) overhead.
ChemInform Abstract: Ultrasound Promoted Bromination of Activated Arenes with N‐ Bromosuccinimide. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Stem cell transplantation compared with melphalan plus dexamethasone in the treatment of immunoglobulin light‐chain amyloidosis (2016)

Although the study had limitations, similar hematologic responses and improved survival were observed after SCT versus melphalan plus dexamethasone. Cancer 2016;122:2197-205. © 2016 American Cancer Society.
A Program-Level Assessment of Student Understanding of Bonding in the Chemistry Major (2021)

Assessment of student learning within a degree program is an important but challenging endeavor. One goal of a programmatic assessment is to systematically collect evidence for chemistry majors’ knowledge and understanding and to use the results to improve curriculum and instruction. Recently, the chemistry department at the United States Naval Academy developed a process to examine student learning in one particular thematic area of chemistry that was addressed in multiple courses throughout the entire curriculum, namely bonding. The assessment included the creation and implementation of an in-house-written, program-level assessment instrument administered to chemistry students at the end of the ACS-certified major. The exam, consisting of 13 free-response items, was collaboratively authored by a group of chemistry department faculty representing the 5 major subdisciplines recognized by the ACS Committee on Professional Training (analytical, biochemistry, inorganic, organic, and physical). Following administration of the instrument to 31 senior chemistry majors, analysis of student work revealed incomplete understanding and errors in process in several areas, including valence bond theory and ligand field theory. These results informed the design of further assessments conducted within the foundation-level lecture courses in the sophomore and junior years of the chemistry major and provided important information on possible areas of improvement within our curriculum.