gebhart/patrepeval huggingface dataset:
Advances in Neural Network Research: IJCNN 2003 (2003)

Perceptual and motor function: adaptive force generation for precision-grip lifting by a spectral timing model of the cerebellum, A. Ulloa, D. Bullock, B.J.Rhodes Radial basis function neural networks for nonlinear Fisher discrimination and Neyman-Pearson classification, D. Casasent, X.W. Chen Intrinsic generalization analysis of low dimensional representations, X. Liu, A. Srivastava Application of four-layer neural network on information extraction, M. Han, L. Cheng, H. Meng Subject independent facial expression recognition with robust face detection, M. Matsugu, K. Mori, Y. Mitari,Y. Kaneda A generalized feedforward neural network architecture for classification and regression, G. Arulampalam, A. Bouzerdoum. Cognitive function and computational neuroscience: Hierarchical cognitive maps, H. Voicu Modeling goal-directed spatial navigation in the rat based on physiological data from the hippocampal formation, R.A. Koene, A. Gorchetchnikov An efficient training algorithm for dynamic synapse neural networks using trust region methods, H.H. Namarvar, T.W. Berger Temporal binding as an inducer for connectionist recruitment learning over delayed lines, C. Gunay, A.S. Maida Developments in understanding neuronal spike trains and functional specializations in brain regions, R.A. Santiago, J. McNames, K. Burchiel, G.G. Lendaris Shaping up simple cell's receptive field of animal visual by ICA and its application in navigation system, L. Zhang, J. Mei eLoom and Flatland - specification, simulation and visualization engines for the study of arbitrary hierarchical neural architectures, T.P. Caudell, Y. Xiao, M.J. Healy Associative morphological memories based on variations of the kernel and dual kernel methods, P. Sussner. Informatics: Adaptive double self-organizing maps for clustering gene expression, H. Ressom, D. Wang, P. Natarajan An accelerated procedure for recursive feature ranking on microarray data, C. Furlanello, M. Serafini, S. Merler, G. Jurman. Dynamics: Pattern completion through phase coding in population neurodynamics, A. Gutierrez-Galvez Passive dendritic integration heavily affects spiking dynamics of recurrent networks, G.A. Ascoli Abductive reasoning with recurrent neural networks, A.M. Abdelbar, E.A.M. Andrews, D.C. Wunsch Neural networks with chaotic recursive nodes - techniques for the design of associative memories, contrast with Hopfield architectures,and extensions for time-dependent inputs, E. Del Moral Hernandez Simple and conditioned adaptive behaviorfrom Kalman filter trained recurrent networks, L.A. Feldkamp, D.V. Prokhorov, T.M. Feldkamp. Reinforcement learning and control: Learning robot actions based on self-organising language memory, S. Wermter, M. Elshaw Autonomous mental development in high dimensional context and action spaces, A. Joshi, J. Weng Chaos control and synchronization, with Input saturation, via recurrent neural networks, E.N. Sanchez, L.J.Ricalde. (Part contents.)
Plasma desorption mass spectrometry of phosphopeptides: An investigation to determine the feasibility of quantifying the degree of phosphorylation (1991)

The intact ion yields of phosphotyrosine, phosphothreonine and mono- and diphosphoserine residue-containing peptides have been compared with the non-phosphorylated sequences using plasma desorption mass spectrometry. Equimolar mixtures of the phosphorylated (Mp) and non-phosphorylated peptides (M) were also analysed. The positive mass spectra of these mixtures show a higher intensity of the [M + H]+ compared with the [Mp + H]+. In the negative mass spectrum, the bias towards the [M - H]- compared with the [Mp - H]- was reduced, but the spectra generally did not accurately reflect the stoichiometry.
46.1: Invited Paper : Novel Design for Full‐Color Electronic Paper (2008)

Abstract Despite a steep increase in commercial devices comprising paper‐like displays, a much desired feature is still missing: bright full‐color electronic paper. We have developed a new reflective display technology to solve this issue. for the first time we will report about the principles behind our in‐plane electrophoretic technology, which enables the realization of full‐color reflective displays with a higher brightness than all present e‐paper technologies, without compromising paper‐like properties like viewing angle and ultra‐low power consumption. An additional major advantage (e.g. for future low‐cost manufacturing) is that, besides direct‐drive and active‐matrix configurations, a passive‐matrix option has been developed successfully.
DMT of MMSE receiver in the frequency selective MIMO channel (2012)

We characterize the DMT of finite-length linear equalizers in the MIMO frequency-selective channel. We obtain the DMT in the case of cyclic-prefix transmission and provide an upper bound for the DMT in the case of zero-padding transmission. We also provide in-depth analysis for the diversity of the MMSE receiver in the fixed rate regime (i.e. zero multiplexing gain) in the cyclic-prefix transmission and obtain a lower bound on diversity. This gives better insight about the diversity of the MMSE in this regime since only upper bound exists in the literature. The MMSE diversity in this regime is function of the spectral efficiency, the data block length and the number of transmit and receive antennas.
Miniaturized Low-Voltage Power Converters With Fast Dynamic Response (2014)

This paper demonstrates a two-stage approach for power conversion that combines the strengths of variable-topology switched capacitor techniques (small size and light-load performance) with the regulation capability of magnetic switch-mode power converters. The proposed approach takes advantage of the characteristics of complementary metal–oxide–semiconductor (CMOS) processes, and the resulting designs provide excellent efficiency and power density for low-voltage power conversion. These power converters can provide low-voltage outputs over a wide input voltage range with very fast dynamic response. Both design and fabrication considerations for highly integrated CMOS power converters using this architecture are addressed. The results are demonstrated in a 2.4-W dc–dc converter implemented in a 180-nm CMOS IC process and co-packaged with its passive components for high performance. The power converter operates from an input voltage of 2.7–5.5 V with an output voltage of ≤1.2 V, and achieves a 2210 W/in <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$^{3}$ </tex-math></inline-formula> power density with ≥80% efficiency.
4th International Congress on Green Process Engineering (GPE2014) continued (2014)

acted as scientific co-chairs of the conference
GENTIAN VIOLET IN SABOURAUD'S MEDIUM FOR ISOLATION OF PATHOGENIC FUNGI (1940)

In the usual diagnosis of dermatophytosis (athlete's foot) scrapings from lesions are examined microscopically for the presence of fungi and inoculated into suitable medium for isolation of suspected strains. The finding of fungi depends largely on proper selection of material. Frequently material loaded with mycelia and spores may not yield a growth of fungi on the planted medium owing to overgrowth of bacterial contamination. To overcome such difficulty, it was found that plain Sabouraud dextrose-peptone medium containing 0.0002 per cent (1: 500,000) gentian violet inhibited the growth of the usual bacterial flora of the skin without hindering the growth of pathogenic molds. Records of a New York mycologic clinic 1 indicated that in approximately 25 per cent of clinical cases of fungous lesions the diagnosis was confirmed by microscopic examination and that in only 50 to 60 per cent of the cases in which the diagnosis was microscopically proved were
Model-based inverse halftoning with wavelet-vaguelette deconvolution (2002)

In this paper, we demonstrate based on the linear model of Kite et al. (1997, 2000) that inverse halftoning is equivalent to the well-studied problem of deconvolution in the presence of colored noise. We propose the use of the simple and elegant wavelet-vaguelette deconvolution (WVD) algorithm to perform the inverse halftoning. Unlike previous wavelet-based algorithms, our method is model-based; hence it is adapted to different error diffusion halftoning techniques. Our inverse halftoning algorithm consists of inverting the convolution operator followed by denoising in the wavelet domain. For signals in a Besov space, our algorithm possesses asymptotically (as the number of samples/spl rarr//spl infin/) near-optimal rates of error decay. Hence for images in a Besov space, it is impossible to improve significantly on the inverse halftoning performance of the WVD algorithm at high resolutions. Using simulations, we verify that our algorithm outperforms or matches the performances of the best published inverse halftoning techniques in the mean square error (MSE) sense and also provides excellent visual performance.
Data from A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; CEA TCB is a novel IgG-based T-cell bispecific (TCB) antibody for the treatment of CEA-expressing solid tumors currently in phase I clinical trials (NCT02324257). Its format incorporates bivalent binding to CEA, a head-to-tail fusion of CEA- and CD3e-binding Fab domains and an engineered Fc region with completely abolished binding to FcγRs and C1q. The study provides novel mechanistic insights into the activity and mode of action of CEA TCB.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; CEA TCB activity was characterized on 110 cell lines &lt;i&gt;in vitro&lt;/i&gt; and in xenograft tumor models &lt;i&gt;in vivo&lt;/i&gt; using NOG mice engrafted with human peripheral blood mononuclear cells.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Simultaneous binding of CEA TCB to tumor and T cells leads to formation of immunologic synapses, T-cell activation, secretion of cytotoxic granules, and tumor cell lysis. CEA TCB activity strongly correlates with CEA expression, with higher potency observed in highly CEA-expressing tumor cells and a threshold of approximately 10,000 CEA-binding sites/cell, which allows distinguishing between high- and low-CEA–expressing tumor and primary epithelial cells, respectively. Genetic factors do not affect CEA TCB activity confirming that CEA expression level is the strongest predictor of CEA TCB activity. &lt;i&gt;In vivo&lt;/i&gt;, CEA TCB induces regression of CEA-expressing xenograft tumors with variable amounts of immune cell infiltrate, leads to increased frequency of activated T cells, and converts PD-L1 negative into PD-L1–positive tumors.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; CEA TCB is a novel generation TCB displaying potent antitumor activity; it is efficacious in poorly infiltrated tumors where it increases T-cell infiltration and generates a highly inflamed tumor microenvironment. &lt;i&gt;Clin Cancer Res; 22(13); 3286–97. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Deep-Unfolded Adaptive Projected Subgradient Method For Mimo Detection (2023)

In this paper, we propose deep-unfolded versions of the recently proposed superiorized adaptive projected subgradient method for MIMO detection. The proposed methods require a single matrix inverse for initialization, and they have a quadratic per-iteration complexity. Extensive simulations with realistic channel models show that the proposed deep-unfolded detectors outperform not only their untrained counterpart, but also existing methods with similar complexity.
Clinical activity of enzalutamide in Docetaxel‐naïve and Docetaxel‐pretreated patients with metastatic castration‐resistant prostate cancer (2014)

The clinical activity of enzalutamide appears to be blunted in patients who have previously received docetaxel chemotherapy. These results support the concept of cross-resistance between these two agents.
Update from the 2011 International Schwannomatosis Workshop: From genetics to diagnostic criteria (2013)

Schwannomatosis is the third major form of neurofibromatosis and is characterized by the development of multiple schwannomas in the absence of bilateral vestibular schwannomas. The 2011 Schwannomatosis Update was organized by the Children's Tumor Foundation (www.ctf.org) and held in Los Angeles, CA, from June 5-8, 2011. This article summarizes the highlights presented at the Conference and represents the "state-of-the-field" in 2011. Genetic studies indicate that constitutional mutations in the SMARCB1 tumor suppressor gene occur in 40-50% of familial cases and in 8-10% of sporadic cases of schwannomatosis. Tumorigenesis is thought to occur through a four-hit, three-step model, beginning with a germline mutation in SMARCB1 (hit 1), followed by loss of a portion of chromosome 22 that contains the second SMARCB1 allele and one NF2 allele (hits 2 and 3), followed by mutation of the remaining wild-type NF2 allele (hit 4). Insights from research on HIV and pediatric rhabdoid tumors have shed light on potential molecular pathways that are dysregulated in schwannomatosis-related schwannomas. Mouse models of schwannomatosis have been developed and promise to further expand our understanding of tumorigenesis and the tumor microenvironment. Clinical reports have described the occurrence of intracranial meningiomas in schwannomatosis patients and in families with germline SMARCB1 mutations. The authors propose updated diagnostic criteria to incorporate new clinical and genetic findings since 2005. In the next 5 years, the authors expect that advances in basic research in the pathogenesis of schwannomatosis will lead toward clinical investigations of potential drug therapies.
7 alpha-iodine-125-iodo-5 alpha-dihydrotestosterone: a radiolabeled ligand for the androgen receptor. (1997)

These studies demonstrate that 7 alpha-[125I]IDHT is an excellent ligand for the androgen receptor.
Optical switching of single-electron tunneling in SiO2∕molecule∕SiO2 multilayer on Si(100) (2004)

Porphyrin-based molecules inserted into the oxide layer of a metal–oxide–semiconductor structure served as Coulomb islands. A Coulomb staircase originating from the single-electron tunneling was observed in a current–voltage curve. We found that light irradiation induced a shift in the Coulomb staircase. This shift was reversible; the shifted Coulomb staircase returned to its original position when the light irradiation was turned off. We thus demonstrated optical switching of a tunneling current. This result indicates that the molecular Coulomb islands have the potential to provide a range of optical functionality in single-electron tunneling devices.
GOBO projection-based high-speed three-dimensional shape measurement (2016)

Pattern projection-based three-dimensional (3-D) measurement systems are well established in various application fields. However, for some time, there has been an increasing demand in terms of a higher measurement speed in order to analyze fast processes. We introduce a GOBO slide-based projector (GOes Before Optics) providing high speed, high radiant flux, and eye-safe incoherent light at low cost. We present its setup as well as the generation and change of the projected patterns. We explain the 3-D measurement principle and show first measurements of an inflating airbag and a rope skipper conducted at a 3-D frame rate of more than 1.3 kHz.
Anti‐Inflammatory Effects of a Methanol Extract from the Marine Sponge Geodia cydonium on the Human Breast Cancer MCF‐7 Cell Line (2015)

Many research groups are working to find new possible anti-inflammatory molecules, and marine sponges represent a rich source of biologically active compounds with pharmacological applications. In the present study, we tested different concentrations of the methanol extract from the marine sponge, Geodia cydonium, on normal human breast epithelial cells (MCF-10A) and human breast cancer cells (MCF-7). Our results show that this extract has no cytotoxic effects on both cell lines whereas it induces a decrease in levels of VEGF and five proinflammatory cytokines (CCL2, CXCL8, CXCL10, IFN-γ, and TNF-α) only in MCF-7 cells in a dose-dependent manner, thereby indicating an anti-inflammatory effect. Moreover, interactomic analysis suggests that all six cytokines are involved in a network and are connected with some HUB nodes such as NF-kB subunits and ESR1 (estrogen receptor 1). We also report a decrease in the expression of two NFKB1 and c-Rel subunits by RT-qPCR experiments only in MCF-7 cells after extract treatment, confirming NF-kB inactivation. These data highlight the potential of G. cydonium for future drug discovery against major diseases, such as breast cancer.
Supplementary Methods, Figure Legends from First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway (2023)

&lt;p&gt;Supplementary Methods and Figure Legends&lt;/p&gt;
Oncogene mutations as intermediate markers (1993)

Tumors arise through a series of genetic changes which include activation of protoocogenes and inactivation of tumor suppressor genes. It is now possible to identify rare cells containing genetic mutations in an excess background of normal cells. Theoretically, the identification of a clonal population of cells sharing an early genetic marker for malignant transformation would lead to valuable intermediate endpoints and could diagnose premalignant lesions amenable to chemoprevention. Ideally, these genetic changes would be specific point mutations that occur early in the tumor cascade, prior to the development of a clinically significant tumor. To identify these markers, precise histopathologic and genetic tumor models must be described. Early candidate markers include p53 point mutations in squamous cell carcinoma of the aerodigestive tract.
ChemInform Abstract: METALLIERUNG VON 1,3‐BIS‐TRIFLUORMETHYL‐BENZOL UND N,N‐DIMETHYL‐3,5‐BIS‐TRIFLUORMETHYL‐ANILIN (1971)

Abstract Die Metallierung des Benzols (Ia) mit dem Komplex aus n‐Butyllithium und N,N,N′,N′‐Tetramethyl‐äthylendiamin erfolgt im wesentlichen nur in 2‐Stellung; mit n‐Butyllithium allein erfolgt dagegen keine exklusive Metallierung an einer Stelle.
Structure–Activity Relationships of 33 Piperidines as Toxicants Against Female Adults ofAedes aegypti(Diptera: Culicidae) (2007)

Aedes aegypti (L.) (Diptera: Culicidae) is the primary vector of both dengue and yellow fever. Use of insecticides is one of the primary ways to control this medically important insect pest. However, few new insecticides have been developed for mosquito control in recent years. As a part of our collaborative effort to search for new insecticides to control mosquitoes, piperidine was used as base compound for further optimization. Herein, we report the structureactivity relationships of 33 piperidines against adult female Ae. aegypti. On the basis of 24-h LD 50 values after topical application, the most toxic compound was 2-ethyl-piperidine, with an LD 50 as low as 0.8 g per mosquito. The toxicities of piperidine derivatives were signicantly decreased when a benzyl moiety was attached to the carbon of the piperidine ring, with an LD 50 value as high as 29.2 g per mosquito. The toxicity order of three moieties attached to the carbon of the piperidine ring was ethyl- methyl- benzyl-derivatives. When the same moiety was attached to the piperidine ring, the carbon position to which the moiety was attached conferred different toxicity and the toxicity order was second carbon third carbon fourth carbon. Together, these preliminary results may be useful in guiding further piperidine ring modications in the development of potential new insecticides.
Defects in CoO in oxidized cobalt nanoparticles dominate exchange biasing and exhibit anomalous magnetic properties (2006)

Defects can vastly modify the optical, electrical, mechanical, and magnetic properties of materials. In this paper, we report an investigation of the magnetic properties of moments associated with defects in CoO in partially and fully oxidized colloidal Co nanoparticles. The defect moments freeze at low temperature and have a distribution of melting temperatures, in which most melt below $50\phantom{\rule{0.3em}{0ex}}\mathrm{K}$, but exchange biasing (EB) generated by the CoO lattice stabilizes the Co core moments in the partially oxidized sample up to $170\phantom{\rule{0.3em}{0ex}}\mathrm{K}$ [J. B. Tracy, D. N. Weiss, D. P. Dinega, and M. G. Bawendi, Phys. Rev. B 72, 064404 (2005)]. By switching the polarity of the biasing field at intermediate temperatures during cooling, we show that the defect moments dominate EB at low temperature and exhibit a thermal memory effect. Selected cooling sequences show that the exchange shift (${H}_{\mathit{EB}}$) may change sign as the sample is heated and demonstrate tuning of ${H}_{\mathit{EB}}$ and the coercivity. Thermal remanent magnetization measurements directly show how changes in the orientation of CoO defect moments cause the Co core moments to reorient. An investigation of the temporal stability of the defect moments is also reported.
[125I]-Atrial Natriuretic Peptide Binding Sites in the Amphibian Testis (1994)

Atrial natriuretic peptide-like immunoreactivity (ANP-like IR) was shown in the testis of Bufo marinus, in the head of mature spermatozoa attached to Sertoli cells, interstitial tissue and seminiferous tubules. After spermiation induced by human chorionic gonadotropin (HCG), testicular spermatozoa failed to show IR. ANP binding sites were localized and characterized in testis of Bufo marinus by quantitative in vitro autoradiography using [125I]-ratANP(99-126). Specific ANP binding demonstrated positive cooperativity. The data suggest a new biological function of ANP in reproduction of male amphibians.
Molecular cloning and possible role of an asparaginyl endopeptidase (REP-2) from germinated rice seeds. (2011)

Two major cysteine endopeptidases, designated REP-1 and REP-2, were separated from extracts of germinated rice seeds by hydrophobic chromatography. REP-1 digested in vitro both the acidic and basic subunits of glutelin, the major storage protein of rice. REP-1 was synthesized as a precursor which has a long prosequence. Accumulation of the REP-1 protein in seeds was controlled by gibberellic acid and abscisic acid. The accumulation of REP-1 mRNA was mainly regulated at the transcriptional level, but the endopeptidase activity in germinating rice seeds developed later than the appearance of REP-1 mRNA, indicating that the expression of REP-1 is regulated also by post-transcriptional events. In the present study, REP-2 was purified from extracts of 9-day germinated rice seeds. In the final step of the purification by gel filtration chromatography, the enzyme was separated into two forms, REP-2α (39 kDa) and REP-2β (40 kDa). The amino-terminal amino acid sequence of REP-2 showed strong similarity to that of asparaginyl endopeptidases (Asn-EPases). The enzyme was immunoreactive to an antiserum raised against legumain, an Asn-EPase from jack bean and had a substrate specificity toward Asn residues. These data indicate that REP-2 is a member of the Asn-EPases that have a strict substrate specificity toward the carboxyl side of Asn residues. A single-stranded cDNA was synthesized from a poly(A) RNA fraction of rice seedlings, and a cDNA product (0.48 kb) amplified by the reverse transcription-polymerase chain reaction (RT-PCR) was obtained using the amino-terminal amino acid sequence and the conserved sequences of known Asn-EPases as primers. The deduced amino acid sequence of this cDNA showed 72% identity to that of VmPE-1, the Asn-EPase from Vigna mungo. A possible role of REP-2 acting on the post-translational processing of REP-1 as well as on the restricted hydrolysis of seed storage proteins is discussed.