gebhart/patrepeval huggingface dataset:
Novel effect of neighboring groups on the quenching of the excited state of a polymer-pendant Ru(bpy)32+ by methyl viologen (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel effect of neighboring groups on the quenching of the excited state of a polymer-pendant Ru(bpy)32+ by methyl viologenMasao Kaneko, Akira Yamada, Eishun Tsuchida, and Yoshimi KurimuraCite this: J. Phys. Chem. 1984, 88, 6, 1061–1062Publication Date (Print):March 1, 1984Publication History Published online1 May 2002Published inissue 1 March 1984https://pubs.acs.org/doi/10.1021/j150650a005https://doi.org/10.1021/j150650a005research-articleACS PublicationsRequest reuse permissionsArticle Views117Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Morphological Transformation of Pd Thin Film Catalysts during 1,3-Butadiene Hydrogenation: An Air and UHV STM Study (1995)

The surface morphology of supported Pd/graphite film catalysts imaged by scanning tunneling microscopy (STM) shows that the microstructure is strongly dependent on the pretreatment and reaction conditions. Results obtained from the ultrahigh vacuum STM have validated the ambient STM images provided the film structures are sufficiently larger than 10 nm. Significant morphological changes occurring during reaction were accompanied by alteration in the activity and selectivity. Three Pd/HOPG films were prepared by exposure to different treatment conditions. It was found that the films with different microstructure exhibit different catalytic behavior, whereas the two films with similar structures prepared by different procedures have similar activity and selectivity.
Vibrational and electronic spectra of tetrakis(formato)diruthenium(1+) (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVibrational and electronic spectra of tetrakis(formato)diruthenium(1+)Vincent M. Miskowski, Thomas M. Loehr, and Harry B. GrayCite this: Inorg. Chem. 1988, 27, 26, 4708–4712Publication Date (Print):December 1, 1988Publication History Published online1 May 2002Published inissue 1 December 1988https://pubs.acs.org/doi/10.1021/ic00299a007https://doi.org/10.1021/ic00299a007research-articleACS PublicationsRequest reuse permissionsArticle Views85Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The prognostic significance of polyclonal bone marrow plasma cells in patients with relapsing multiple myeloma (2017)

Prior studies have revealed that the presence of increasing number of polyclonal plasma cells (pPCs) in the bone marrow (BM) are associated with better outcomes in newly diagnosed multiple myeloma (MM) patients. This effect has not been studied in patients with MM at the time of disease relapse. We determined the prognostic value of depletion of pPCs in the BM by 7-color multiparameter flow cytometry in a series of 174 relapsing MM patients. The time to next therapy (TTNT) in those with <5% pPCs was 9.4 months versus 13.9 months in those with ≥5% pPCs (P = .0091). The median overall survival (OS) in those with <5% pPCs was 21.4 months, while the median OS was not reached in those patients with ≥5% pPCs (P = .019). Of the 109 patients with standard risk cytogenetics, the median OS of those with <5% pPCs was 28.4 months, while the median OS was not reached in those with ≥5% pPCs (P = .033). As such, <5% pPCs in the BM appears to have prognostic utility in identifying a subset of relapsing MM patients, even with standard-risk cytogenetics, who have a particularly adverse outcome.
P4‐353: A PHASE 2 TRIAL OF THE EFFICACY AND SAFETY OF THE ALPHA7 AGONIST ABT‐126 AS AN ADD‐ON TREATMENT IN MILD‐TO‐MODERATE ALZHEIMER'S DEMENTIA (2014)

In a previous Phase 2a monotherapy study, ABT-126, a novel a 7 neuronal nicotinic receptor agonist, was associated with a small improvement in cognition in mild-to-moderate Alzheimer's dementia (AD) patients. The current study evaluated ABT-126 as an add-on treatment to donepezil or rivastigmine. This randomized, double-blind, placebo-controlled, multinational study targeted enrollment of 420 subjects with mild-to-moderate AD (Mini-Mental Status Examination [MMSE] score of 12-24, inclusive). Subjects receiving stable doses of donepezil or rivastigmine were randomized to ABT-126 (25mg or 75mg QD) or placebo for 24 weeks. The primary efficacy endpoint was the change from baseline to Week 24 in the 11-item Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog) total score. It was analyzed by mixed-effects model for repeated measures using factors of treatment, site, visit and treatment-by-visit interaction, with baseline score and baseline-by-visit interaction as covariates. All P values shown are one-sided. A prespecified subgroup analysis examined the effects of ABT-126 by baseline disease severity (MMSE 12-19 or 20-24). Adverse events (AEs) were monitored, and sparse pharmacokinetic samples were collected. The study randomized 434 patients with mean (SD) age of 75.1 (7.7) years and mean (SD) baseline MMSE of 18.9 (4.4) (no significant difference across treatment groups). Fifty-seven (13.1%) subjects prematurely discontinued (comparable across treatment groups). Neither dose of ABT-126 separated significantly from placebo on the 11-item ADAS-Cog (LS mean [SE] difference from placebo: 25 mg: -0.80 [0.59], P =0.087; 75 mg: -0.13 [0.59], P =0.416). In subjects with mild AD (MMSE 20-24), the treatment difference between 25 mg ABT-126 and placebo on the ADAS-Cog was more pronounced (1.44 point improvement over placebo at Week 24, P =0.022). ABT-126 plasma levels were consistent with predictions. Among treatment groups, AE and serious AE rates (SAE) were comparable (placebo, 25 mg, and 75 mg): AE (68%, 64%, 70%), SAE (8.9%, 6.3%, 6.9%). Common AEs are shown in Table 1. ABT-126 did not improve performance on the AD AS-Cog in subjects with mild-to-moderate AD, but in subjects with mild AD the 25 mg dose showed a small, statistically significant improvement versus placebo. ABT-126 had an adequate safety profile in these mild-to-moderate AD patients.
“Of Mice and Measures”: A Project to Improve How We Advance Duchenne Muscular Dystrophy Therapies to the Clinic (2018)

A new line of dystrophic mdx mice on the DBA/2J (D2) background has emerged as a candidate to study the efficacy of therapeutic approaches for Duchenne muscular dystrophy (DMD). These mice harbor genetic polymorphisms that appear to increase the severity of the dystropathology, with disease modifiers that also occur in DMD patients, making them attractive for efficacy studies and drug development. This workshop aimed at collecting and consolidating available data on the pathological features and the natural history of these new D2/mdx mice, for comparison with classic mdx mice and controls, and to identify gaps in information and their potential value. The overall aim is to establish guidance on how to best use the D2/mdx mouse model in preclinical studies.
Parallel operation of 50 element two-dimensionalCMOS smart-pixel receiver array (1998)

Test results from a two-dimensional array of 50 CMOS smart-pixel receivers equipped with both optical and electrical outputs are reported. Parallel testing of the array at 311 Mbit/s indicates a ~2.5 dB penalty for operation of nearly the whole array as compared to a single element.
Chemistry of Silicon‐Containing Amino Acids (2009)

This chapter contains sections titled: Introduction Synthesis of Silicon-Containing Amino Acids Reactions of Silicon-Containing Amino Acids Bioactive Peptides Incorporating Silicon-Substituted Amino Acids Conclusions Experimental Procedures References
Mechanical Alloying Process of Al-6 at%Ti Mixed Powders by a High Energy Planetary Ball Mill (1995)

The mechanical alloying(MA) process of Al-6 at%Ti mixed powders under a surging mode of a high energy planetary ball mill in Ar gas, at the maximum centrifugal acceleration of 40, 80, 120 and 150 G(G is the gravitational acceleration), was investigated by means of microscopic observation, X-ray diffraction, hardness measurement and quantitative analysis of the composition. The MA process proceeds in the following three stages; At the 1st stage both the coalescence of Al and Ti elemental powders and adhering on the pot-wall and the surface of balls occur. The amount of such adhesions increases with milling time. At the 2nd stage, almost all Al-Ti mixed powders adhere on the pot-wall and the ball surfaces, and the dissolution of Ti and Fe atoms into Al powders, work-hardening and the refining of the crystal grains to the nano-size proceed under compressional, frictional and shearing stresses, due to the surging motion of the milling balls. At the 3rd stage, the hardened(Hv: 400∼500) powders, consisting of nano-size crystals of Al-6 at%Ti-1 at%Fe supersaturated solid solution, fall down from the pot-wall and the ball surfaces during milling. In the 3rd stage, the higher the MA energy, the larger the amount of the powders obtained and the greater the hardness of the powders. At the same time, the higher milling intensity caused the faster progress of the MA process. The average grain size of the Al-6 at%Ti-1 at%Fe alloy powders milled for a long time is from 13 to 17 nm, depending on milling intensity during MA. Higher milling intensity tends to bring a smaller grain size. No amorphous phase is detected.
Relationship between Fried’s frailty phenotype and oral frailty in long-term care residents (2021)

OFr is related to Fried's frailty phenotype, general health, nutrition and need for help with daily activities.
Application specific loss minimization using gradient boosting (2011)

Gradient boosting is a flexible machine learning technique that produces accurate predictions by combining many weak learners. In this work, we investigate its use in two applications, where we show the advantage of loss functions that are designed specifically for optimizing application objectives. We also extend the original gradient boosting algorithm with Newton-Raphson method to speed up learning. In the experiments, we demonstrate that the use of gradient boosting and application specific loss functions results in a relative improvement of 0.8% over an 82.6% baseline on the CoNLL 2003 named entity recognition task. We also show that this novel framework is useful in identifying regions of high word error rate (WER) and can provide up to 20% relative improvement depending on the chosen operating point.
Downlink B3G MIMO OFDMA Link and System Level Performance (2008)

This paper provides a link and system level study of the downlink in a B3G system using MIMO OFDMA techniques. A 3GPP/LTE-like scenario, in terms of frame structure and system main parameters, is considered in this study. At the link level, the double Alamouti MIMO scheme is studied and the performances of various modulation and coding schemes (MCS) are provided. The impact of real MIMO channel estimation (including RF impairments, CFO compensation and automatic gain control AGC) on the MCSs link performance is also presented. System level study is thus carried out to assess the performance of the downlink OFDMA in terms of coverage and cell throughput. Several scheduling disciplines and MIMO schemes are investigated and the impact of the spatial diversity on the cell throughput is provided. This study has been carried out in the scope of the French RNRT OPUS project.
Ultrasound Signal Processing: From Models to Deep Learning (2022)

Medical ultrasound imaging relies heavily on high-quality signal processing to provide reliable and interpretable image reconstructions. Conventionally, reconstruction algorithms where derived from physical principles. These algorithms rely on assumptions and approximations of the underlying measurement model, limiting image quality in settings were these assumptions break down. Conversely, more sophisticated solutions based on statistical modelling, careful parameter tuning, or through increased model complexity, can be sensitive to different environments. Recently, deep learning based methods, which are optimized in a data-driven fashion, have gained popularity. These model-agnostic techniques often rely on generic model structures, and require vast training data to converge to a robust solution. A relatively new paradigm combines the power of the two: leveraging data-driven deep learning, as well as exploiting domain knowledge. These model-based solutions yield high robustness, and require less parameters and training data than conventional neural networks. In this work we provide an overview of these techniques from recent literature, and discuss a wide variety of ultrasound applications. We aim to inspire the reader to further research in this area, and to address the opportunities within the field of ultrasound signal processing. We conclude with a future perspective on model-based deep learning techniques for medical ultrasound.
Mobile phone based mini-spectrometer for rapid screening of skin cancer (2015)

We demonstrate a highly sensitive mobile phone based spectrometer that has potential to detect cancerous skin lesions in a rapid, non-invasive manner. Earlier reports of low cost spectrometers utilize the camera of the mobile phone to image the field after moving through a diffraction grating. These approaches are inherently limited by the closed nature of mobile phone image sensors and built in optical elements. The system presented uses a novel integrated grating and sensor that is compact, accurate and calibrated. Resolutions of about 10 nm can be achieved. Additionally, UV and visible LED excitation sources are built into the device. Data collection and analysis is simplified using the wireless interfaces and logical control on the smart phone. Furthermore, by utilizing an external sensor, the mobile phone camera can be used in conjunction with spectral measurements. We are exploring ways to use this device to measure endogenous fluorescence of skin in order to distinguish cancerous from non-cancerous lesions with a mobile phone based dermatoscope.
Supplementary material from "High-performance single-walled carbon nanotube transparent conducting film fabricated by using low feeding rate of ethanol solution" (2018)

We report floating catalyst chemical vapour deposition synthesis of single-walled carbon nanotubes (SWCNTs) for high-performance transparent conducting films (TCFs) using low feeding rate of precursor solution. Herein, ethanol acts as carbon source, ferrocene and thiophene as catalyst precursor and growth promoter, respectively. By adopting a low feeding rate of 4 μl min<sup>−1</sup>, the fabricated TCFs present one of the lowest sheet resistances of <i>ca</i> 78 ohm/sq. at 90% transmittance. Optical characterizations demonstrate that the mean diameter of high-quality SWCNTs is up to 2 nm. Additionally, electron microcopy observations provide the evidences that the mean length of SWCNT bundles is as long as 28.4 μm while the mean bundle diameter is only 5.3 nm. Moreover, very few CNT loops can be found in the film. Remarkably, the fraction of individual SWCNTs climbs up to 24.6%. All those morphology data account for the superior optoelectronic performance of our SWCNT TCFs.
Clinical Outcomes at 1 Year Following Transcatheter Aortic Valve Replacement (2015)

Among patients undergoing TAVR in US clinical practice, at 1-year follow-up, overall mortality was 23.7%, the stroke rate was 4.1%, and the rate of the composite outcome of death and stroke was 26.0%. These findings should be helpful in discussions with patients undergoing TAVR.
Expression of a CD200 Transgene Is Necessary for Induction but Not Maintenance of Tolerance to Cardiac and Skin Allografts (2009)

CD200, a type 2 transmembrane molecule of the Ig supergene family, can induce immunosuppression in a number of biological systems, as well as promote increased graft acceptance, following binding to its receptors (CD200Rs). Skin and cardiac allograft acceptance are readily induced in transgenic mice overexpressing CD200 under control of a doxycycline-inducible promoter, both of which are associated with increased intragraft expression of mRNAs for a number of genes associated with altered T cell subset differentiation, including GATA-3, type 2 cytokines (IL-4, IL-13), GITR, and Foxp3. Interestingly, some 12-15 days after grafting, induction of transgenic CD200 expression can be stopped (by doxycycline withdrawal), without obvious significant effect on graft survival. However, neutralization of all CD200 expression (including endogenous CD200 expression) by anti-CD200 mAb caused graft loss, as did introduction of an acute inflammatory stimulus (LPS, 10 microg/mouse, delivered by i.p. injection). We conclude that even with apparently stably accepted tissue allografts, disruption of the immunoregulatory balance by an intense inflammatory stimulus can cause graft loss.
Progress in mid-IR Cr^2+ and Fe^2+ doped II-VI materials and lasers [Invited] (2011)

Recent progress in fabrication and mid-IR lasing of transition metal doped II-VI single crystal and thermo-diffusion doped polycrystalline and hot-pressed ceramic gain media as well as nano and micro-crystalline laser active powders, powders in the liquid suspension, polymer-film, thin film waveguides and chalcogenides glass composites is reported.
Comparative Glycomics Analysis of Influenza Hemagglutinin (H5N1) Produced in Vaccine Relevant Cell Platforms (2013)

Hemagglutinin (HA) is the major antigen in influenza vaccines, and glycosylation is known to influence its antigenicity. Embryonated hen eggs are traditionally used for influenza vaccine production, but vaccines produced in mammalian and insect cells were recently licensed. This raises the concern that vaccines produced with different cell systems might not be equivalent due to differences in their glycosylation patterns. Thus, we developed an analytical method to monitor vaccine glycosylation through a combination of nanoLC/MS(E) and quantitative MALDI-TOF MS permethylation profiling. We then used this method to examine glycosylation of HAs from two different influenza H5N1 strains produced in five different platforms, including hen eggs, three different insect cell lines (High Five, expresSF+ and glycoengineered expresSF+), and a human cell line (HEK293). Our results demonstrated that (1) sequon utilization is not necessarily equivalent in different cell types, (2) there are quantitative and qualitative differences in the overall N-glycosylation patterns and structures produced by different cell types, (3) ∼20% of the N-glycans on the HAs produced by High Five cells are core α1,3-fucosylated structures, which may be allergenic in humans, and (4) our method can be used to monitor differences in glycosylation during the cellular glycoengineering stages of vaccine development.
The thumb: guidelines for a robotic design (2010)

The impressive manipulation capabilities of the human hand are undoubtedly related to the thumb opposition. Such a versatility is highly desirable in the context of humanoid robots, in particular when performing object manipulation. Biomechanical data, surgery procedures and rehabilitation surveys represent an excellent base from which a robotic design can be inferred. This knowledge must be understood to identify the properties required for manipulation skills, and especially, to obtain a holistic view of the thumb functionality. Several designs have been realized, that concentrated on biomimetism or on classical mechanism designs. Therefore, it is currently difficult for designers to obtain a clear overview of the properties required for a functional robot thumb. In the present case, a robotic hand with size, forces, velocity and shape comparable to the human ones, is envisioned. Unlike most of robotic designs-where the fingers are modular and the thumb is simply a finger placed in opposition-the thumb benefits from an intensive functional analysis. This paper gathers anatomy, surgery and rehabilitation data and identifies the properties required for human like manipulation. Based on this synergy, guidelines are presented that are fused and applied to the hand design of the Integrated Hand arm project of DLR.
Cell stiffness and receptors: evidence for cytoskeletal subnetworks (2004)

Viscoelastic models of cells often treat cells as homogeneous objects. However, studies have demonstrated that cellular properties are local and can change dramatically on the basis of the location probed. Because membrane receptors are linked in various ways to the intracellular space, with some receptors linking to the cytoskeleton and others diffusing freely without apparent linkages, the cellular physical response to mechanical stresses is expected to depend on the receptor engaged. In this study, we tested the hypothesis that cellular mechanical stiffness as measured via cytoskeletally linked receptors is greater than stiffness measured via receptors that are not cytoskeletally linked. We used a magnetic micromanipulator to apply linear stresses to magnetic beads attached to living cells via selected receptors. One of the receptor classes probed, the dystroglycan receptors, is linked to the cytoskeleton, while the other, the transferrin receptors, is not. Fibronectin-coated beads were used to test cellular mechanical properties of the cytoskeleton without membrane dependence by allowing the beads to endocytose. For epithelial cells, transferrin-dependent stiffness and endocytosed bead-dependent stiffness were similar, while dystroglycan-dependent stiffness was significantly lower. For smooth muscle cells, dystroglycan-dependent stiffness was similar to the endocytosed bead-dependent stiffness, while the transferrin-dependent stiffness was lower. The conclusion of this study is that the measured cellular stiffness is critically influenced by specific receptor linkage and by cell type and raises the intriguing possibility of the existence of separate cytoskeletal networks with distinct mechanical properties that link different classes of receptors.