gebhart/patrepeval huggingface dataset:
External stimulation-controllable heat-storage ceramics (2015)

Commonly available heat-storage materials cannot usually store the energy for a prolonged period. If a solid material could conserve the accumulated thermal energy, then its heat-storage application potential is considerably widened. Here we report a phase transition material that can conserve the latent heat energy in a wide temperature range, T<530 K and release the heat energy on the application of pressure. This material is stripe-type lambda-trititanium pentoxide, λ-Ti3O5, which exhibits a solid-solid phase transition to beta-trititanium pentoxide, β-Ti3O5. The pressure for conversion is extremely small, only 600 bar (60 MPa) at ambient temperature, and the accumulated heat energy is surprisingly large (230 kJ L(-1)). Conversely, the pressure-produced beta-trititanium pentoxide transforms to lambda-trititanium pentoxide by heat, light or electric current. That is, the present system exhibits pressure-and-heat, pressure-and-light and pressure-and-current reversible phase transitions. The material may be useful for heat storage, as well as in sensor and switching memory device applications.
The catalepsy test: Its ups and downs. (1988)

The typical catalepsy test consists of placing an animal into an unusual posture and recording the time taken to correct this posture. This time is regarded as an index of the intensity of catalepsy. Catalepsy is a robust behavior, and the lack of standardization does not usually hinder its actual detection. However, the intensity of the cataleptic effect is influenced by minor methodological differences, and thus interpretation and comparison of results across laboratories are difficult. The behavioral catalepsy test can use any of several different apparatus, including wire grids, parallel bars, platforms, or pegs, to situate the animals in unusual positions. The most common, however, is the "bar test," and despite its wide use in psychopharmacological research, even parameters of this test are not standardized. The present article reviews the wide variety of parameters chosen by investigators that measure catalepsy. The methodological issues of repeated testing, scaling of scores, apparatus, animal weight, maximal test duration, behavioral criteria, and other influences are discussed. In addition, a brief review of the neuropharmacological basis of catalepsy is also included. Finally, it is argued that a universal, standardized bar test be adopted by researchers. New data on a novel automated bar test in the Digiscan Activity Monitoring System is presented.
Optical-Thermal-Electrical Model for a Single Cell PV Module in Non-Steady-State and Non-Uniform Conditions Build in SPICE (2013)

An optical-thermal-electrical model of a photovoltaic (PV) module was developed in SPICE. The mixed-signal model consists of two coupled sub-circuits, one sub-circuit to describe the thermal response and one to incorporate electrical characteristics of the PV module. In this paper, various types of thermal equivalent RCnetworks and the extraction procedure of parameters for the thermal sub-circuit are explained in detail. The thermal sub-circuit is used to simulate module temperatures as a function of illumination level, ambient temperature, wind conditions, electrical load (by coupling the thermal sub-circuit to the electrical sub-circuit) and illumination history. Since the model has been built in SPICE, it can be used to evaluate PV module characteristics during transient and non-uniform conditions. The complete model can be used to calculate the energy yield, to investigate thermal and electrical characteristics of the module and to evaluate energy yield losses due to non-steady-state and non-uniform illumination and ambient conditions.
Contribution of Circulating Progenitor Cells to Vascular Repair and Lesion Formation (2007)

The accumulation of smooth muscle cells (SMCs) plays a principal role in atherogenesis, postangioplasty restenosis, and transplantation-associated vasculopathy. Therefore, much effort has been expended in targeting the migration and proliferation of medial SMCs to prevent occlusive vascular remodeling. Recent findings have suggested that bone marrow-derived precursors can also give rise to vascular cells that contribute to repair, remodeling, and lesion formation. This article overviews recent findings on circulating vascular progenitor cells and describes potential therapeutic strategies that target these cells.
Demonstration of Uncoupled 4-Core Multicore Fiber in Submarine Cable Prototype With Integrated Multicore EDFA (2022)

We developed a 15.2-km submarine cable prototype which can accommodate up to 16 fiber pairs (FPs) of 125 μm standard cladding diameter 4-core uncoupled multicore fiber (UC-MCF). Fiber properties such as loss, chromatic dispersion, and inter-core crosstalk were measured and compared before and after cabling. We found that the cabling process, such as fiber rewinding, copper tubing and polyethylene coating completion, did not significantly change the fiber properties such as loss. To verify the influence of cabling process on long-haul transmission performance, we fabricated a 60.8-km length 4-core UC-MCF transmission span by serially splicing four FPs from the 15.2-km length cabled 4-core UC-MCF. An experimental loop transmission setup was established using the cabled transmission span, and Q-value was measured in real-time. The 120 wavelength multiplexed channels were transmitted. The five channels were modulated by 100 Gbps 34.7 GBd polarization multiplexed quadrature phase shift keying (PM-QPSK) signal and the other channels were loading channels shaped from amplified spontaneous emission (ASE). We changed the transmission direction one core at a time in the 4-core UC-MCF based transmission line to examine the effect of inter-core crosstalk on the transmission line. The −25-dB inter-core crosstalk caused negligible signal degradation in the 4-core UC-MCF and fan-in fan-out (FIFO) a total of 88 spans. Furthermore, we found that the 5,350-km transmission using cabled 4-core UC-MCF was limited by optical signal to noise ratio (OSNR). We integrated the transmission 4-core UC-MCF with the 4-core UC-MC-erbium doped fiber amplifier (EDFA) without using FIFO and clarified experimentally a Q-value improvement of 0.6 dB by removing half number of the FIFOs.
Real Time Xray Probing of the Insulator to Metal Phase Transitionin Titanium Penta-Oxyde Nanocrystals (2019)

National audience
Émission paramétrique dans les microcavités de semiconducteurs : fonction de corrélation du second ordre (2012)

Communication orale
Editorial Comment (1985)

No AccessJournal of Urology1 Mar 1985Editorial Comment Ralph V. Clayman Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)49016-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial Comment." The Journal of Urology, 133(3), p. 451 © 1985 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 133Issue 3March 1985Page: 451 Advertisement Copyright & Permissions© 1985 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Ralph V. Clayman More articles by this author Expand All Advertisement Loading ...
Supplementary Figure 2 from Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing Peptibody (2023)

Supplementary Figure 2 from Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing Peptibody
Supplemental Table 4 from An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2 (2023)

&lt;p&gt;Supplemental Table 4. Targets of drugs identified as more effective in TTF1-low cell lines.&lt;/p&gt;
Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers (2019)

We hypothesized that candidate dependencies for which there are small molecules that are either approved or in advanced development for a nononcology indication may represent potential therapeutic targets. To test this hypothesis, we performed genome-scale loss-of-function screens in hundreds of cancer cell lines. We found that knockout of <i>EGLN1</i>, which encodes prolyl hydroxylase domain-containing protein 2 (PHD2), reduced the proliferation of a subset of clear cell ovarian cancer cell lines <i>in vitro</i>. EGLN1-dependent cells exhibited sensitivity to the pan-EGLN inhibitor FG-4592. The response to FG-4592 was reversed by deletion of HIF1A, demonstrating that EGLN1 dependency was related to negative regulation of HIF1A. We also found that ovarian clear cell tumors susceptible to both genetic and pharmacologic inhibition of EGLN1 required intact HIF1A. Collectively, these observations identify EGLN1 as a cancer target with therapeutic potential. SIGNIFICANCE: These findings reveal a differential dependency of clear cell ovarian cancers on EGLN1, thus identifying EGLN1 as a potential therapeutic target in clear cell ovarian cancer patients.
Astaxanthin Inhibits H2O2-Mediated Apoptotic Cell Death in Mouse Neural Progenitor Cells via Modulation of P38 and MEK Signaling Pathways (2009)

In the present study, neuroprotective effects of astaxanthin on H2O2-mediated apoptotic cell death using cultured mouse neural progenitor cells (mNPCs) were investigated. To cause apoptotic cell death, mNPCs were pretreated with astaxanthin for 8 h and followed by treatment of 0.3 mM H2O2. Pretreatment of mNPCs with astaxanthin significantly inhibited H2O2-mediated apoptosis and induced cell growth in a dose-dependent manner. In Western blot analysis, astaxanthin-pretreated cells showed the activation of p-Akt, p-MEK, p-ERK, and Bcl-2, and the reduction of p-P38, p-SAPK/JNK, Bax, p-GSK3beta, cytochrome c, caspase-3, and PARP. Because H2O2 triggers caspases activation, this study examined whether astaxanthin can inhibit caspases activation in H2O2-treated mNPCs. After H2O2 treatment, caspases activities were prominently increased but astaxanthin pretreatment significantly inhibited H2O2-mediated caspases activation. Astaxanthin pretreatment also significantly recovered ATP production ability of H2O2-treated cells. These findings indicate that astaxanthin inhibits H2O2-mediated apoptotic features in mNPCs. Inhibition assays with SB203580 (10 microM, a specific inhibitor of p38) and PD98059 (10 microM, a specific inhibitor of MEK) clearly showed that astaxanthin can inhibit H2O2-mediated apoptotic death via modulation of p38 and MEK signaling pathways.
A tagless coherence directory (2009)

A key challenge in architecting a CMP with many cores is maintaining cache coherence in an efficient manner. Directory-based protocols avoid the bandwidth overhead of snoop-based protocols, and therefore scale to a large number of cores. Unfortunately, conventional directory structures incur significant area overheads in larger CMPs.
Importance of the Nucleophilic Property of Tea Polyphenols (2018)

Tea is the second most popular beverage in the world after water. Vast accumulative evidence attest that tea consumption may promote human health, such as antioxidant, anti-obesity, and anticancer activities. Therefore, tea phytochemicals have drawn exceeding attention from researchers in structure confirmation, formation mechanism, component clarification, and bioactivity screening of interested constituents. Particularly, most investigations of chemical or biochemical reactions of catechins have concentrated on the B ring of the C6-C3-C6 skeleton. Hence, in this perspective, we reviewed the profound findings of the carbon-carbon (C-C) connection from the unambiguous characterization of novel A-ring addition derivatives of tea catechins, including catechin-carbonyl and catechin-theanine conjugates and the C-C formation mechanisms, and offered our view of the potential effects of catechin-carbonyl interactions on flavor generation and bioactive action in tea.
Mechanistic insights into boron-catalysed direct amidation reactions (2018)

The generally accepted monoacyloxyboron mechanism of boron-catalysed direct amidation is brought into question in this study, and new alternatives are proposed. We have carried out a detailed investigation of boron-catalysed amidation reactions, through study of the interaction between amines/carboxylic acids and borinic acids, boronic acids and boric acid, and have isolated and characterised by NMR/X-ray crystallography many of the likely intermediates present in catalytic amidation reactions. Rapid reaction between amines and boron compounds was observed in all cases, and it is proposed that such boron-nitrogen interactions are highly likely to take place in catalytic amidation reactions. These studies also clearly show that borinic acids are not competent catalysts for amidation, as they either form unreactive amino-carboxylate complexes, or undergo protodeboronation to give boronic acids. It therefore seems that at least three free coordination sites on the boron atom are necessary for amidation catalysis to occur. However, these observations are not consistent with the currently accepted 'mechanism' for boron-mediated amidation reactions involving nucleophilic attack of an amine onto a monomeric acyloxyboron intermediate, and as a result of our observations and theoretical modelling, alternative proposed mechanisms are presented for boron-mediated amidation reactions. These are likely to proceed <i>via</i> the formation of a dimeric B-X-B motif (X = O, NR), which is uniquely able to provide activation of the carboxylic acid, whilst orchestrating the delivery of the amine nucleophile to the carbonyl group. Quantum mechanical calculations of catalytic cycles at the B3LYP+D3/Def2-TZVPP level (solvent = CH<sub>2</sub>Cl<sub>2</sub>) support the proposal of several closely related potential pathways for amidation, all of which are likely to be lower in energy than the currently accepted mechanism.
Big data challenges in decoding cortical activity in a human with quadriplegia to inform a brain computer interface (2016)

Recent advances in Brain Computer Interfaces (BCIs) have created hope that one day paralyzed patients will be able to regain control of their paralyzed limbs. As part of an ongoing clinical study, we have implanted a 96-electrode Utah array in the motor cortex of a paralyzed human. The array generates almost 3 million data points from the brain every second. This presents several big data challenges towards developing algorithms that should not only process the data in real-time (for the BCI to be responsive) but are also robust to temporal variations and non-stationarities in the sensor data. We demonstrate an algorithmic approach to analyze such data and present a novel method to evaluate such algorithms. We present our methodology with examples of decoding human brain data in real-time to inform a BCI.
A 1.7-GHz 1.5-mW digitally-controlled FBAR oscillator with 0.03-ppb resolution (2008)

In this paper, a 1.5 mW, 1.7 GHz BAW oscillator with a multi-bit sigma-delta DAC based fine frequency tuning to achieve a frequency resolution of about 50 mHz or 0.03 ppb over a tuning range of 6.4 MHz is presented. The oscillator achieves a phase noise of -97 dBc/Hz at an offset of 10 kHz.
FITMOS modeling and dynamic on-state characteristic evaluation (2010)

This paper presents a study of the detailed characteristics of the new Floating Island and Thick Bottom Oxide Trench Gate MOSFET (FITMOS) developed at Toyota. FITMOS has tremendous potential for automotive applications due to its low on-resistance, improved temperature coefficient of resistance and low gate charge. During the study, the key characteristics of this novel FITMOS were investigated; a behavioral model was developed in SPICE for simulation and optimization purposes, and their applications in the design of automotive power electronics was explored. In this study, we also identify a previously unrecognized phenomenon in the FITMOS MOSFET. In particular, we show that the on-state resistance of the device depends on both frequency and peak di/dt at a given frequency. This dynamic on-resistance variation can have a significant application impact.
Abstract WP110: Infarct Topography On MRI In Patients With Acute Ischemic Stroke And Atrial Fibrillation: Subgroup Analysis From PER DIEM Trial (2022)

Background: Atrial fibrillation (AF) is a common cause of ischemic stroke; however, it is often difficult to detect. It is unclear whether specific infarct topography on magnetic resonance imaging (MRI) is associated with underlying AF. We aimed to objectively assess the infarct patterns on MRI in patients with acute ischemic stroke and determine imaging characteristics that are associated with AF. Methods: We conducted a subgroup analysis on patients randomized in Post-Embolic Rhythm Detection with Implantable vs External Monitoring trial (PER DIEM; NCT02428140) who had brain MRI. Two raters blinded to clinical details reviewed the MRI findings. Patients were divided to two groups (AF and non-AF) and descriptive statistics were used to characterize findings. Variables associated with new AF were analyzed using logistic regression and reported as odds ratios (OR) with 95% confidence interval (CI) and p -values. Results: Of the 300 patients who were randomized in the trial, 249 (83%) patients (59.4% male) with a mean age of 64.3 ± 13.1 years had MRI brain and were included in the analysis. Median (IQR) NIHSS was 0 (0 - 1), number of lesions was 2 (1 - 3), and diameter of lesion (mm) was 10.4 (5.8 - 21.1) mm. In this cohort of patients, imaging characteristics were not significantly associated with the detection of AF. Conclusions: Association between infarct topography and AF detection was not found in this study. Imaging characteristics cannot be relied upon to predict or exclude an underlying AF. Large prospective studies are suggested to examine the link between infarct topography and underlying AF.
283: Feasibility of Combining Ultrasonic and Magnetic-Resonance Methods for Improved Tissue-Type Imaging of Prostate Cancer (2007)

You have accessJournal of UrologyModerated Poster 10, Sunday, May 20, 2007, 10:00 am - 12:00 pm1 Apr 2007283: Feasibility of Combining Ultrasonic and Magnetic-Resonance Methods for Improved Tissue-Type Imaging of Prostate Cancer Ernest J. Feleppa, Christopher R. Porter, Shreedevi Dasgupta, Andrew Kalisz, Sarayu Ramachandran, Jeffrey A. Ketterling, Marc J. Lacrampe, David Dail, and Deborah Sparks Ernest J. FeleppaErnest J. Feleppa More articles by this author , Christopher R. PorterChristopher R. Porter More articles by this author , Shreedevi DasguptaShreedevi Dasgupta More articles by this author , Andrew KaliszAndrew Kalisz More articles by this author , Sarayu RamachandranSarayu Ramachandran More articles by this author , Jeffrey A. KetterlingJeffrey A. Ketterling More articles by this author , Marc J. LacrampeMarc J. Lacrampe More articles by this author , David DailDavid Dail More articles by this author , and Deborah SparksDeborah Sparks More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)30548-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "283: Feasibility of Combining Ultrasonic and Magnetic-Resonance Methods for Improved Tissue-Type Imaging of Prostate Cancer." The Journal of Urology, 177(4S), p. 95 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 95 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Ernest J. Feleppa More articles by this author Christopher R. Porter More articles by this author Shreedevi Dasgupta More articles by this author Andrew Kalisz More articles by this author Sarayu Ramachandran More articles by this author Jeffrey A. Ketterling More articles by this author Marc J. Lacrampe More articles by this author David Dail More articles by this author Deborah Sparks More articles by this author Expand All Advertisement Loading ...
Supplementary Figure Legend from hTERT Inhibition Triggers Epstein–Barr Virus Lytic Cycle and Apoptosis in Immortalized and Transformed B Cells: A Basis for New Therapies (2023)

&lt;p&gt;PDF file - 85K&lt;/p&gt;
A Circuit and Architecture Codesign Approach for a Hybrid CMOS–STTRAM Nonvolatile FPGA (2010)

Research efforts to develop a novel memory technology that combines the desired traits of nonvolatility, high endurance, high speed, and low power have resulted in the emergence of spin-torque transfer RAM (STTRAM) as a promising next-generation universal memory. Although industrial efforts have been made to design efficient embedded memory arrays using STTRAM, the prospect of developing a nonvolatile field-programmable gate array (FPGA) framework with STTRAM exploiting its high integration density remains largely unexplored. In this paper, we propose a novel CMOS-STTRAM hybrid FPGA framework, identify the key design challenges, and propose optimization techniques at circuit, architecture, and application mapping levels. We show that intrinsic properties of STTRAM that distinguish it from conventional static RAM (SRAM), such as asymmetric readout power, where a cell storing “0” has 5× less read power than a cell storing “1”, can be leveraged to skew lookup table contents for FPGA power reduction. We also argue that the proposed framework should operate on static voltage-sensing-based logic evaluation. We identify static power dissipation during logic evaluation and read noise margin as key design concerns and present an optimized resistor-divider design for voltage sensing to reduce static power and noise margin. Finally, we investigate the effectiveness of Shannon-decomposition-based supply gating to reduce static power. Simulation results show improvement of 44.39% in logic area and 22.28% in delay of a configurable logic block (CLB) and average improvement of 16.1% dynamic power over a conventional CMOS FPGA design for a set of benchmark circuits.
Anti‐interleukin‐6 monoclonal antibody inhibits autoimmune responses in a murine model of systemic lupus erythematosus (2006)

Systemic lupus erythematosus (SLE) is an autoimmune disease resulting from dysregulation of the immune system. Interleukin-6 (IL-6) is a multifunctional cytokine produced by macrophages, monocytes and T and B cells. It stimulates B-cell differentiation/maturation, immunoglobulin secretion, and T-cell functions. Elevated levels of IL-6 in serum, urine and renal glomeruli were detected in patients with active SLE and in murine models of SLE. Our study investigated the role of IL-6 in an SLE-like disease in New Zealand Black/White (NZB/W) F1 mice by administration of an anti-murine IL-6 monoclonal antibody (mAb). Intraperitoneal administration of the anti-IL-6 mAb suppressed the production of anti-dsDNA autoantibody. B-cell proliferation induced by anti-IgM and anti-CD40 was lower in the anti-IL-6 mAb-treated mice, ex vivo studies demonstrated that anti-IL-6 mAb treatment inhibited anti-dsDNA production. Anti-CD3-induced T-cell proliferation and mixed lymphocyte reactions were inhibited by anti-IL-6 mAb treatment, indicating a partial down-regulation of T cells. Histological analysis showed that treatment with anti-IL-6 mAb prevented the development of severe kidney disease. These results suggest that treatment with anti-IL-6 mAb has a beneficial effect on autoimmunity in murine SLE and that autoreactive B cells may be the primary target for anti-IL-6 mAb treatment; its effect on autoreactive T cells is also indicated.