gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Haem d1: Stereoselective Synthesis of the Macrocycle to Establish Its Absolute Configuration as 2R, 7R. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Spatially Consistent Geometric D2D Small-Scale Fading Model for\n Multiple Frequencies (2019)

The 3GPP new radio (NR) channel model introduced spatial consistency and a\ncorrelation model for multiple frequencies. Future extensions of this model\nwill incorporate mobility at both ends of the link. These features are\nessential for many emerging wireless technologies in the 5G era. However, the\nexisting small-scale-fading (SSF) model does not integrate these features\ncoherently. To solve this problem, we propose a new SSF model that seamlessly\nintegrates with the remaining NR model and allows the simultaneous simulation\nof all three features. We demonstrate this integration by showing that the\noutput of the new SSF model agrees well with large-scale fading (LSF) parameter\ndistributions provided by 3GPP. This enables the simulation of new wireless\ntechnology proposals that were difficult to realize with existing\ngeometry-based stochastic channel models (GSCMs).\n
Supplementary Table from Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma (2023)

Supplementary Table from Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma
Aggregate planning models incorporating productivity—an overview (1982)

Abstract Most aggregate planning models utilize a constant productivity factor throughout the planning horizon. Recently new work has been done to incorporate changing productivity factors into aggregate planning models; however, some of these models have certain limitations and unrealistic assumptions. The objective of this paper is to present an overview of the state of the art in combining aggregate planning models with learning curve productivity considerations.
In Vitro Continuous 3 Months Operation of Direct Electron Transfer Type Open Circuit Potential Based Glucose Sensor: Heralding the Next CGM Sensor (2022)

The DET-type OCP glucose sensor can be continuously operated for more than 3 months at 25 °C, in vitro without significant decreases in sensor signal and sensitivity. While the further investigation will be required for in vivo validation, the DET-type OCP glucose sensor is ideal for next generation CGM's, especially in long duration implantable use cases.
Delay and Bypass: Ready and Criticality Aware Instruction Scheduling in Out-of-Order Processors (2020)

Flexible instruction scheduling is essential for performance in out-of-order processors. This is typically achieved by using CAM-based Instruction Queues (IQs) that provide complete flexibility in choosing ready instructions for execution, but at the cost of significant scheduling energy. In this work we seek to reduce the instruction scheduling energy by reducing the depth and width of the IQ. We do so by classifying instructions based on their readiness and criticality, and using this information to bypass the IQ for instructions that will not benefit from its expensive scheduling structures and delay instructions that will not harm performance. Combined, these approaches allow us to offload a significant portion of the instructions from the IQ to much cheaper FIFO-based scheduling structures without hurting performance. As a result we can reduce the IQ depth and width by half, thereby saving energy. Our design, Delay and Bypass (DNB), is the first design to explicitly address both readiness and criticality to reduce scheduling energy. By handling both classes we are able to achieve 95% of the baseline out-of-order performance while only using 33% of the scheduling energy. This represents a significant improvement over previous designs which addressed only criticality or readiness (91%/89% performance at 74%/53% energy).
A Critical Survey of the Rheological Properties Used to Predict Friction Reducer Performance (2022)

Abstract Increased interest in correlating rheological properties to the prediction of proppant transport and/or friction reduction performance produces sporadic and isolated experimental evidence. Obtaining accurate results specifically for viscosity, proposedly representative of proppant transport and friction reduction, is challenging and therefore, extrapolating polymer melt rheology to dilute polymer solutions is problematic particularly when applying linear viscoelastic theory. This paper presents a simultaneous, multivariable research approach illustrating how viscoelastic results and hypotheses for anionic, cationic, and amphoteric friction reducers in various brines provide insight into the limitations of constricted variable and experimental range methodology. Establishing a relevant application window for viscoelastic friction reducers is complicated. Guar gum linear gels are viscous in nature and more approachable than synthetic friction reducers when manipulated for rheological experimentation and field application extrapolation. However, crosslinking of guar gum linear gels results in a viscoelastic fluid of greater complexity, thus even the simplest of linear gels must be subjected to a variety of unique bench tests differentiated by and specific to individual service companies’ field application requirements. Friction reducers’ crossover of storage and loss moduli are dependent upon how the reducers were dispersed and hydrated with respect to brine characters, times, and mixing energies. Furthermore, correlating rheological measurements developed for the melt state may not appropriately adapt to the friction reducer application's dilute polymer state. Response surfaces were generated for various anionic, cationic, and amphoteric friction reducers with testing variables including brine type, loading, mixing rpm, mixing duration, shear rate, linear shear strain, responses of viscosity, and moduli with corresponding cross over results. Excellent regression was obtained from these complex, interactive response surfaces, revealing the breadth of variability obtained from complex experimentation and validating that studies using simplistic procedures provide limited and potentially biased performance conclusions. When relating rheology to friction reduction and proppant transport, whether in the lab or the field, and understanding the complexities of polymer absolute dispersion, dissolution, and kinetics indicate that, with respect to performance prediction, limited knowledge is gained from simple polymer make down regimens. This work offers a guideline for assimilating comprehensive studies of complex versus oversimplified, limited scope rheological measurement research and analyses.
Molecular cloning of hepatitis delta virus RNA from an infected woodchuck liver: sequence, structure, and applications (1988)

cDNA prepared from the single-stranded circular RNA genome of hepatitis delta virus was cloned in lambda gt11 by using RNA from the liver of an infected woodchuck. From the sequence of overlapping clones, we assembled the full sequence of 1,679 nucleotides. The sequence indicated an exceptional ability for intramolecular base pairing, yielding a rod structure with at least 70% of the bases paired and a predicted free energy of -805 kcal (-3,368 kJ)/mol. Three of the lambda clones contained sequences that were not only expressed as fusion proteins with beta-galactosidase but were recognized by human hepatitis delta virus-specific antibody. These clones were sequenced so as to establish the reading frame of the delta antigen on the antigenomic strand. The fusion protein produced by one clone was purified by immunoaffinity chromatography and then was used to raise rabbit antibodies specific for the delta antigen.
CHARACTERIZATION OF TURBIDITIC OIL RESERVOIRS BASED ON GEOPHYSICAL MODELS OF THEIR FORMATION (2005)

The complete pseudo-three dimensional equations for the vertically averaged simplified suspension balance model (VASSBM) are presented for the simulation of the dynamics and deposition of concentrated turbidity currents. This simplified model is the result of the analysis of more exact equations for the flow and sedimentation process of turbidity currents. In previous reports we have presented the VASSBM model for two-dimensional flows of constant volume or constant sediment flux. Here we generalize the equations to describe three-dimensional flows. We conclude with discussions on how the model may be implemented for oil reservoir characterization.
Shill bidding in multi-round online auctions (2003)

The online implementation of traditional business mechanisms raises many new issues not considered in classical economic models. This partially explains why online auctions have become the most successful but also the most controversial Internet businesses in recent years. One emerging issue is that the lack of authentication over the Internet has encouraged shill bidding, the deliberate placing of bids on the seller's behalf to artificially drive up the price of the seller's auctioned item. Private-value English auctions with shill bidding can result in a higher expected seller profit than other auction formats (W. Wang et al., 2001), violating the classical revenue equivalence theory. The paper analyzes shill bidding in multi-round online English auctions and proves that there is no equilibrium without shill bidding. Taking into account the seller's shills and relistings, bidders with valuations even higher than the reserve will either wait for the next round or shield their bids in the current round. Hence, it is inevitable to redesign online auctions to deal with the "shiller's curse".
Counting networks (1994)

Many fundamental multi-processor coordination problems can be expressed as counting problems : Processes must cooperate to assign successive values from a given range, such as addresses in memory or destinations on an interconnection network. Conventional solutions to these problems perform poorly because of synchronization bottlenecks and high memory contention. Motivated by observations on the behavior of sorting networks, we offer a new approach to solving such problems, by introducing counting networks , a new class of networks that can be used to count. We give two counting network constructions, one of depth log n (1 + log n )/2 using n log (1 + log n )/4 “gates,” and a second of depth log 2 n using n log 2 n /2 gates. These networks avoid the sequential bottlenecks inherent to earlier solutions and substantially lower the memory contention. Finally, to show that counting networks are not merely mathematical creatures, we provide experimental evidence that they outperform conventional synchronization techniques under a variety of circumstances.
Abstract 35: Transendocardial Mesenchymal Stem Cell Injection Demonstrates Reverse Remodeling Effects of Global LV Volumes and Enhanced Lateral Papillary Muscle Shortening (2017)

Rationale: Secondary mitral regurgitation (MR) carries a poor prognosis despite improvements in surgical and transcatheter interventions. Mesenchymal stem cell (MSC) therapy for heart disease reduces infarct size and left ventricle (LV) dilatation, reverses remodeling, and improves regional contractility and functional capacity. However, it is unknown if the benefits of MSC therapy on LV structure and function apply to lateral papillary muscle shortening, an important predictor of secondary MR severity. Hypothesis: Test the hypothesis that administration of MSCs promotes interpapillary muscle distance (IPMD) shortening. Methods/Results: This retrospective analysis draws on results from autologous or allogeneic MSC injection therapies in a Göttingen swine model of chronic ischemic cardiomyopathy (ICM). MRI was used to measure end-diastolic volume (EDV), end-systolic volume (ESV), diastolic/systolic IPMD, and IPMD shortening. NOGA mapping and angiographic tracings of left ventriculography allowed for assessment of the effect of injection localized to papillary muscles (defined as injection within cardiac segments 4, 6, 10 and 12 in the 16-segment model). Three months after stem cell injection, EDV increased in both placebo- (12.2±3.6 mL; p=0.002) and MSC- (10.2±2.6 mL; p=0.03) treated swine. ESV increased only in placebo- (7.1±2.2 mL; p=0.003) but not MSC- treated swine. Systolic IPMD was maintained with MSC therapy (1.20±0.74 mm; p=0.33) but increased in placebo (1.83±0.60 mm; p=0.01). Systolic IPMD was preserved whether MSC injection was localized to papillary muscle (0.53±0.49 mm; p=0.44) or not (0.22±0.40 mm; p=0.24). Notably, IPMD shortening was significantly greater in MSC- (8.1±5.6%; p=0.02) but not placebo-injected (4.7±5.0%; p=0.69) swine. There were no between group differences in IPMD shortening (p=0.08). Conclusion: This study is the first to show that transendocardial MSC injections significantly enhanced IPMD shortening and lateral interpapillary muscle contraction in a model of chronic ICM. This effect was independent of injection site.
Oral Vitamin A Therapy for a Patient With a Severely Symptomatic Postradiation Anal Ulceration (2003)

Squamous-cell carcinoma of the anus is an uncommon but treatable gastrointestinal malignancy. Radiation, in addition to chemotherapy, is widely accepted as the standard of care for treatment in most patients. However, significant anal complications, such as stricture, fistula, and ulceration, may result from radiation therapy. Some medical therapies have been used for radiation proctopathy, but treatments for radiation-induced anal injury other than surgical diversion are unknown. Vitamin A has been shown in laboratory studies to facilitate wound healing and prevent radiation-induced gastrointestinal damage. However, it has not been used clinically in patients with radiation enteritis, proctopathy, or anal ulceration. We report a case of a patient with human immunodeficiency virus infection who developed a symptomatic anal ulcer after receiving high-dose radiotherapy for anal squamous-cell carcinoma. We prescribed 8,000 IU of oral vitamin A twice daily and within seven weeks his anorectal symptoms and anal ulcer completely resolved. Vitamin A seems to be very effective in the treatment of radiation-induced anorectal damage, with little toxicity and expense.
FontMatcher (2018)

One of the important aspects in graphic design is choosing the font of the caption that matches aesthetically the associated image. To obtain a good match, users would exhaustively examine a long font list requiring them a substantial effort. This paper presents FontMatcher, which supports users to design digital graphic works harmoniously pairing fonts with an image. The system provides three features, recommendation, explaination and feedback. If a warm feeling image is given as input, the system recommends warm feeling fonts, and then explains what is the distinguishing features of the recommendation, e.g. a cursive shape. Users can also provide feedback to find fonts which correspond to their intention. Our evaluation results show that the recommended fonts scored better than selected fonts by novices and provides competing results with the ones chosen by experienced graphic designers. The system also provides explanations that help increasing the reliability of the recommended results.
Supplementary Figure S2 from Delivery of Telomerase Reverse Transcriptase Small Interfering RNA in Complex with Positively Charged Single-Walled Carbon Nanotubes Suppresses Tumor Growth (2023)

Supplementary Figure S2 from Delivery of Telomerase Reverse Transcriptase Small Interfering RNA in Complex with Positively Charged Single-Walled Carbon Nanotubes Suppresses Tumor Growth
What's Hot in Intelligent User Interfaces (2016)

The ACM Conference on Intelligent User Interfaces (IUI) is the annual meeting of the intelligent user interface community and serves as a premier international forum for reporting outstanding research and development on intelligent user interfaces. ACM IUI is where the Human-Computer Interaction (HCI) community meets the Artificial Intelligence (AI) community. Here we summarize the latest trends in IUI based on our experience organizing the 20th ACM IUI Conference in Atlanta in 2015.
Abstract 1115: Targeted RNA sequencing improves transcript analysis in cancer samples (2015)

Abstract RNA sequencing (RNA-seq) is a transcriptome profiling technology that provides multiple levels of insight into the genome. In addition to expression levels (transcript abundance), it generates endpoints such as alternative splicing, somatic mutations and rearrangements, which may have functional consequences in cancer. Although somatic mutations are generally identified by DNA sequencing, RNA-seq has the advantage of detecting allele-specific expression affecting a variant allele, as well as functional chimeric transcripts that result from structural rearrangements. Compared to microarray technologies, RNA-seq can provide additional information about novel transcripts. Due to the complexity of the human transcriptome and the variability of gene abundance, the cost of whole transcriptome sequencing to achieve sufficient coverage to detect these types of alterations remains high. To explore the feasibility of a more cost-effective method, we compared the performance of three different RNA-seq methods: whole-transcriptome-, exome-, and targeted RNA-seq, using RNA derived from cancer cell lines and Formaldehyde Fixed-Paraffin Embedded (FFPE) samples. For whole-transcriptome preparation, we used the Illumina TruSeq Stranded mRNA and total RNA kits for cell line and FFPE samples, respectively. Exome-RNAseq was performed using the Illumina Access kit. The libraries from whole-transcriptome RNAseq were subjected to hybridization capture using OncoPanel-an Agilent SureSelect baitset of 500 cancer-related genes. Compared to whole-transcriptome, exome- and targeted-RNA-seq demonstrated (1) higher coding exon coverage and multiplexing capability; (2) reduced rRNA composition to 1%; (3) comparable gene abundance information and (4) over 90% of reads aligned to coding exon regions in FFPE samples, compare to ∼30% when using whole transcriptome method. In conclusion, we demonstrated that exome- and targeted RNA-seq provide a cost-effective way to analyze a subset of the transcriptome. Furthermore, targeted RNA-seq can be highly multiplexed and is therefore amenable for large-scale tumor profiling in clinical or research settings. Citation Format: Ling Lin, Ryan Abo, Deniz Dolcen, Rachel Paquette, Angelica Laing, Luc de Waal, Aaron Thorner, Matthew Ducar, Liuda Ziaugra, Bruce Wollison, Marc Breneiser, William Hahn, Matthew Meyerson, Paul Van Hummelen, Laura MacConaill. Targeted RNA sequencing improves transcript analysis in cancer samples. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1115. doi:10.1158/1538-7445.AM2015-1115
Infrared vibrational nanocrystallography and nanoimaging (2016)

Molecular solids and polymers can form low-symmetry crystal structures that exhibit anisotropic electron and ion mobility in engineered devices or biological systems. The distribution of molecular orientation and disorder then controls the macroscopic material response, yet it is difficult to image with conventional techniques on the nanoscale. We demonstrated a new form of optical nanocrystallography that combines scattering-type scanning near-field optical microscopy with both optical antenna and tip-selective infrared vibrational spectroscopy. From the symmetry-selective probing of molecular bond orientation with nanometer spatial resolution, we determined crystalline phases and orientation in aggregates and films of the organic electronic material perylenetetracarboxylic dianhydride. Mapping disorder within and between individual nanoscale domains, the correlative hybrid imaging of nanoscale heterogeneity provides insight into defect formation and propagation during growth in functional molecular solids.
Deriving divide-and-conquer dynamic programming algorithms using solver-aided transformations (2016)

We introduce a framework allowing domain experts to manipulate computational terms in the interest of deriving better, more efficient implementations.It employs deductive reasoning to generate provably correct efficient implementations from a very high-level specification of an algorithm, and inductive constraint-based synthesis to improve automation. Semantic information is encoded into program terms through the use of refinement types.
HSD3B1 (1245A>C) polymorphism and clinical outcomes in metastatic castration-resistant prostate cancer (mCRPC) patients treated with abiraterone acetate (AA) and enzalutamide (ENZA): Results from two prospective studies. (2020)

5525 Background: The common HSD3B1 (1245A &gt; C) germline variant is associated with increased de-novo synthesis of androgens and worse outcomes in men treated with androgen-deprivation therapy in metastatic hormone sensitive prostate cancer. The aim of this study is to determine the role of this polymorphism on treatment outcomes for AA and ENZA in patients with mCRPC. Methods: A total of 547 patients treated with AA or ENZA for mCRPC from two prospective cohorts; cohort 1 included 202 from British Columbia (Canada) and cohort 2 enrolled 345 patients from the Spanish study PROREPAIR-B. HSD3B1 genotype was determined by targeted sequencing in cohort 1 and by Taqman SNP genotyping assay in cohort 2. Associations between HSD3B1 genotypes and (TTPP), time to progression (TTP) and overall survival (OS) were evaluated via univariate COX regression. Multivariate analysis was performed to determine the independent association of each covariate. Results: The proportions of patients with a homozygous wild-type HSD3B1 (AA), heterozygous (AC) and homozygous variant (CC) genotype were respectively 45.6%, 39.4% and 15%. As expected, known prognostic factors for mCRPC such as hemoglobin, alkaline phosphatase (ALP), LDH, PSA at baseline as well as site of metastasis were significantly associated with TTPP and TPP. In the combined cohort, HSD3B1 (CC) genotype was associated with worse TTP (HR 1.31, 95%CI 1.02-1.67, p = 0.032) and PSA response rates (48% for CC vs 62% and 65% for AA and AC, respectively (p = 0.019, χ²)). Similar trend was observed for TTPP (HR 1.28, 95%CI 0.99-1.66, p = 0.064). OS was not different among genotypes, but was significantly shorter for patients with CC genotype in cohort 1 (HR 1.97, 95%CI 1.14-3.40, p = 0.016). There was no association between HSD3B1 genotype and time to castration-resistance in either of the two cohorts. Multivariable analysis showed that LDH, ALP, hemoglobin and use of AA or ENZA as first-line therapy for mCRPC were independent prognostic factors for TTP and TTPP; non-significant association was observed for genotype and TTP. Conclusions: HSD3B1 homozygous variant genotype (CC) was associated with shorter TTP and lower PSA response rate in mCRPC patients treated with AA or ENZA. However, the CC genotype did not provide prognostic information beyond that conferred by standard clinical variables, suggesting that it may not be a suitable stand-alone biomarker in mCRPC.