gebhart/patrepeval huggingface dataset:
An Advanced Technique for Linear Low‐Density Polyethylene Composition Determination: TGA–IST16–GC–MS Coupling (2019)

Abstract An innovative method based on thermogravimetric analysis combined with gas chromatography and mass spectrometry, TGA–IST16–GC–MS, is developed for measuring the comonomer type and the comonomer content in a series of linear low‐density polyethylenes (LLDPE). LLDPE such as copolymers of ethylene and octene or ethylene and hexene are synthetized using the Et(Ind) 2 ZrCl 2 zirconium‐metallocene catalyst. Their characterization with TGA‐IST16‐GC‐MS system is compared to one of the polyethylenes prepared under similar conditions and used as reference. TGA‐IST16‐GC‐MS allows discriminating the comonomer type (hexene or octene) and content. Combining the versatility of thermal analysis and the accuracy and sensitivity of mass spectrometry, this original method proves to be very useful for routine characterization of LLDPE. It has the advantage of being quicker and more easily performed that traditional means of obtaining copolymer compositions such as nuclear magnetic resonance, or through separation techniques such as temperature rising elution fractionation (TREF).
Effect of the Fresnel membranous prism on the visual function. (2007)

[目的]フレネル膜プリズムの視機能への影響を比較検討する。[対象及び方法]対象は、視力や視機能に問題のない正常者9名9眼。年齢21～29(24.8±3.12)歳、屈折度は+0.5～-5.0(-1.47±1.63)D。完全矯正レンズ下の片眼に(1)6Δ(2)8Δ(3)10Δ(4)12Δ(5)15Δ(6)20Δ(7)30Δの7種の膜プリズムを基底外方に貼付し、1、視力2、コントラスト感度(AULCSF)3、グレアテスト4、波面センサーによる眼球高次収差と、前方散乱係数(コントラスト法)を測定し、それぞれ膜プリズムの有無による比較を行った。また、5、自覚的装用感についてのアンケートも行った。[結果]膜プリズム無しと比較して、1、2では8Δ以上の加入で有意な視力、AULCSFの低下(P<0.01)が、3のグレア下では12Δ以上の加入から有意な感度低下がみられた(P<～0.05)。また膜プリズム下でのグレアの有無による比較では、8Δ以上の加入でグレア有りの場合グレアなしと比べて有意に感度が低下していた(P=～0.05)。眼球収差では、総高次収差(C3+C4)は12Δと30Δで有意に増加し(P<0.05)、前方散乱係数は12Δ以上の加入で有意な増加があった(P<0.05)。5では、プリズム度が大きくなるにつれ自覚的装用感が悪化した。[結論]8Δ以上のフレネル膜プリズムを処方する際には視力、コントラスト感度、グレア、散乱などの視機能への影響を考慮する必要がある。
Vacuum sealed and getter activated MEMS Quad Mass Gyroscope demonstrating better than 1.2 million quality factor (2016)

This paper presents the in-run bias stability of a high Q-factor Quad Mass Gyroscope (QMG), vacuum sealed with getter activated in Leadless Chip Carrier (LCC) package. Quality factors of 1.2 and 1.1 Million were measured along the layout-defined drive and sense modes. As-fabricated, frequency mismatch of 35Hz was electrostatically tuned to 200mHz, for a device with 2kHz center frequency. A performance improvement of 4X in Angle Random Walk (ARW) and 15X reduction in in-run bias stability were achieved after the electrostatic frequency matching between drive and sense modes, resulting in below 0.1 deg/hr bias stability. The results showed a strong dependency of the in-run bias stability of the gyroscope due to quality factor and frequency mismatches.
Modeling and Imaging through a Gas-Obscured Zone in Malaysia (2014)

We demonstrate using viscoelastic modeling followed by dual velocity RTM imaging that ocean bottom node (OBN) survey is needed in a gas-obscured zone in Malaysia. Scattering caused by “geobodies” filled or partially filled with gas will distort the P-wave propagation. S-wave, on the other hand, is less sensitive to the geobodies, and therefore has a good chance for imaging through gas-obscured zones. However, when intrinsic Q (or attenuation) is present in the overburden, the ability of PS-converted wave imaging will be degraded. The reliability and resolution of PS-converted wave imaging also depends on the accuracy of velocity models used for RTM imaging.
Analytical Compact Model for Opto-Mechanical Sensor (2020)

Opto-mechanical resonators have demonstrated over the past decade their tremendous potential for mass and chemical detection. The transducer is able to resonate both in the air and in a liquid environment and presents a very low level of noise, a very high optical quality factor and an excellent density of integration. Currently, the readout electronics available for opto-mechanical transducers are mainly bulky laboratory equipment and it is necessary to integrate them. This paper presents a compact analytical model of an opto-mechanical system implemented in Simulink and compatible with electrical simulator to ease the design of electronic readout circuits. The proposed model describes both the optical and mechanical behavior, as well as opto-mechanical coupling. It also integrates thermo-optical effect and is in good agreement with experimental measurements.
HPTAM, a two-dimensional Heat Pipe Transient Analysis Model, including the startup from a frozen state (1995)

A two-dimensional Heat Pipe Transient Analysis Model, 'HPTAM,' was developed to simulate the transient operation of fully-thawed heat pipes and the startup of heat pipes from a frozen state. The model incorporates: (a) sublimation and resolidification of working fluid; (b) melting and freezing of the working fluid in the porous wick; (c) evaporation of thawed working fluid and condensation as a thin liquid film on a frozen substrate; (d) free-molecule, transition, and continuum vapor flow regimes, using the Dusty Gas Model; (e) liquid flow and heat transfer in the porous wick; and (f) thermal and hydrodynamic couplings of phases at their respective interfaces. HPTAM predicts the radius of curvature of the liquid meniscus at the liquid-vapor interface and the radial location of the working fluid level (liquid or solid) in the wick. It also includes the transverse momentum jump condition (capillary relationship of Pascal) at the liquid-vapor interface and geometrically relates the radius of curvature of the liquid meniscus to the volume fraction of vapor in the wick. The present model predicts the capillary limit and partial liquid recess (dryout) in the evaporator wick, and incorporates a liquid pooling submodel, which simulates accumulation of the excess liquid in the vapor core at the condenser end.
Priority-based classification of spectrum access models [Accepted From Open Call] (2013)

The reforms in spectrum management aim toward more efficient, flexible, and shared use of spectrum, while fostering innovation and competition in mobile communications. The goal is to have affordable wireless broadband and make Internet access a human right. To achieve this goal, the regulators need to identify, evaluate, and decide between the different spectrum access models. This article presents a taxonomy of the models, which is based on priorities between the different users of spectrum. For example, the low priority systems may be allowed to use the spectrum only if the high priority systems are not occupying the frequency. The hierarchy of the systems can be implemented using different technologies such as centralized databases or distributed sensing devices. The taxonomy clarifies the regulatory alternatives and emphasizes the differences in ownership and usage rights. The new models can be incorporated in the auction design in order to estimate their value to the companies, and this reflects the recent trend of supporting spectrum management with market- based methods.
Seebeck Measurements of N-Doped Diamond Thin Film (2002)

It was reported that although nitrogen (N) forms either 1.7 or 4.0 eV deep level donor in diamond, these levels do not contribute to the electrical conduction at room temperature. It was also reported that hydrogen (H)-termination of diamond surfaces results in the p-type electrical conduction in CVD diamond, and that this conduction can be diminished by subsequent oxygen (O) treatment. In this paper, the conduction type of N-doped CVD diamond studied through thermoelectric measurements is presented. The measurements of the Seebeck coefficient indicate that: (i) as-grown N-doped CVD diamond shows p-type conduction, (ii) once it is oxidized, it presents n-type electrical conduction with carrier concentrations of about 1018 cm—3. The results suggest the presence of competing bipolar transport between the surface and the bulk in CVD diamond.
Porcine Neural Progenitor Cells Derived from Tissue at Different Gestational Ages Can Be Distinguished by Global Transcriptome (2017)

The impact of gestational age on mammalian neural progenitor cells is potentially important for both an understanding of neural development and the selection of donor cells for novel cell-based treatment strategies. In terms of the latter, it can be problematic to rely entirely on rodent models in which the gestational period is significantly shorter and the brain much smaller than is the case in humans. Here, we analyzed pig brain progenitor cells (pBPCs) harvested at 2 different gestational ages (E45 and E60) using gene expression profiles, obtained by microarray analysis and quantitative polymerase chain reaction (qPCR), across time in culture. Comparison of the global transcriptome of pBPCs from age-matched transgenic green flourescent protein (GFP)-expressing fetuses versus non- GFP-expressing fetuses did not reveal significant differences between the 2 cell types, whereas comparison between E45 and E60 pBPCs did show separation between the data sets by principle component analysis. Further examination by qPCR showed evidence of relative downregulation of proliferation markers and upregulation of glial markers in the gestationally older (E60) cells. Additional comparisons were made. This study provides evidence of age-related changes in the gene expression of cultured fetal porcine neural progenitors that are potentially relevant to the role of these cells during development and as donor cells for transplantation studies.
Novel Fe–Pd/γ-Al2O3 catalysts for the selective hydrogenation of C≡C bonds under mild conditions (2019)

Novel promising Fe–Pd/γ-Al2O3 catalysts for the selective liquid-phase hydrogenation of unsaturated compounds (phenylacetylene and 2-methylbut-3-yn-2-ol) under ambient conditions have been prepared. They were characterized by low temperature nitrogen adsorption, XRD, SEM, TEM, TPR-H2 and DRIFTS-CO techniques. The presence of Pd–Fe nanoparticles led to increased reactivity and selectivity of the new catalysts in hydrogenation of the C≡C bond to the C=C one as compared to those of the Pd/Al2O3 system.
Biocompatibility of white cell filters as evaluated complement activation (1992)

The biocompatibility of nine different white cell filters was examined by analysis of complement activation in plasma specimens obtained from blood components before and after filtration. Filters for both red cell (RBC) concentrates and platelet concentrates (PCs) were tested. It was found in all of the filters tested that the postfiltration levels of complement activation products were not higher than the prefiltration levels in RBC concentrates and PCs. One exception was the filtration of multiple PCs with Imugard IG-500, in which case a rise in C3 activation products was seen. Moreover, there was a significant rise in C3 activation products, but not the terminal complement complex, when plasma was filtered through Imugard E, which contrasted with results with the other filters. High initial and storage time-dependent levels, especially of C3 activation products, were observed in the PCs, probably due to their processing at room temperature. It can be concluded that the majority of the filters tested do not activate complement.
Evolution of core density of Ag-clad Bi-2223 tapes during process (2001)

The porosity and its effect on critical current density J/sub c/ of Ag-clad (Bi,Pb)/sub 2/Sr/sub 2/Ca/sub 2/Cu/sub 3/O/sub x/ (Bi-2223) tapes throughout important steps in their thermomechanical treatment was investigated by using mass density measurement, microstructural observation, and superconducting property characterization. The relative mass density of the final filament for 19 filament tape was less than 75%, even though the J/sub c/ is /spl sim/50 kA/cm/sup 2/ (77 K, 0 T). The mass density in monofilaments reached 90%, because retrograde densification during the first heat treatment (HT1) was less or even absent. Well textured Bi-2223 grain growth could result in a significant densification during the first HT in the monofilament composite. Our results hint at considerable variability in this important property of Bi-2223 tape.
Morphology manipulation of M13 bacteriophage template for nanostructure assembly (2014)

A gold-binding M13 bacteriophage was used as a model system to explore templating of inorganic material on geometrically transformed viruses . Gold-binding filamentous phage were converted to spheroid form with a short chloroform treatment, and the resulting morphology was investigated with electron microscopy. Binding studies revealed that spheroid-shaped gold-binding phage preserved its affinity for gold. Spheroids adhered to a planar substrate assembled clusters or rings of gold nanoparticles. This gold-binding phage served as a demonstration of a highly shape-modifiable viral-template for inorganic materials.
High-throughput spatial sensitive quantitative phase microscopy using low spatial and high temporal coherent illumination (2021)

High space-bandwidth product with high spatial phase sensitivity is indispensable for a single-shot quantitative phase microscopy (QPM) system. It opens avenue for widespread applications of QPM in the field of biomedical imaging. Temporally low coherence light sources are implemented to achieve high spatial phase sensitivity in QPM at the cost of either reduced temporal resolution or smaller field of view (FOV). In addition, such light sources have low photon degeneracy. On the contrary, high temporal coherence light sources like lasers are capable of exploiting the full FOV of the QPM systems at the expense of less spatial phase sensitivity. In the present work, we demonstrated that use of narrowband partially spatially coherent light source also called pseudo-thermal light source (PTLS) in QPM overcomes the limitations of conventional light sources. The performance of PTLS is compared with conventional light sources in terms of space bandwidth product, phase sensitivity and optical imaging quality. The capabilities of PTLS are demonstrated on both amplitude (USAF resolution chart) and phase (thin optical waveguide, height ~ 8 nm) objects. The spatial phase sensitivity of QPM using PTLS is measured to be equivalent to that for white light source and supports the FOV (18 times more) equivalent to that of laser light source. The high-speed capabilities of PTLS based QPM is demonstrated by imaging live sperm cells that is limited by the camera speed and large FOV is demonstrated by imaging histopathology human placenta tissue samples. Minimal invasive, high-throughput, spatially sensitive and single-shot QPM based on PTLS will enable wider penetration of QPM in life sciences and clinical applications.
Primary Urethral Clear-Cell Adenocarcinoma (2014)

Primary clear-cell adenocarcinoma of the urethra, a rare tumor that histomorphologically resembles clear-cell carcinoma of the female genital tract, occurs predominantly in women and is associated with a relatively poor prognosis. The histogenesis of this rare urethral neoplasm has not been completely resolved, but it is thought to arise from either müllerian rests or metaplastic urothelium. Herein, we present comprehensive surgical pathological and cytopathological findings from a patient with primary urethral clear-cell adenocarcinoma and describe next-generation sequencing results for this patient's unique tumor-the first such reported characterization of molecular aberrations in urethral clear-cell adenocarcinoma at the transcriptomic and genomic levels. Transcriptome analysis revealed novel gene fusion candidates, including ANKRD28-FNDC3B. Whole-exome analysis demonstrated focal copy number loss at the SMAD4 and ARID2 loci and 38 somatic mutations, including a truncating mutation in ATM and a novel nonsynonymous mutation in ALK.
New Anti-Inflammatory/Anti-Arthritic Heterocyclic Bisphosphonates (1996)

Abstract The 2,4–di–tert–butyl–6–methylphenyl substituent was placed on phosphorus of a phosphole, causing restricted rotation about the P–C bond and flattening of the phosphorus pyramid. Electron delocalization was greater in this phosphole as a result of the flattening. The 7–phosphanorbornene with this substituent had the most deshielded 31p nucleus ever recorded in this series, and thermally decomposed with formation of a diphosphene, suggesting a phosphinidene intermediate.
NONLINEAR AND ELECTRO-OPTICS OF NANO-DISPERSED NEMATIC LIQUID CRYSTALS WITH TUNABLE NEGATIVE-, ZERO-, AND POSITIVE INDICES (2007)

We present a review of recent progress in the studies of the nonlinear- and electro-optics of liquid crystals, particularly in their meta-material forms. An analytical expression for the "ultimate" optical nonlinearity of nematic liquid crystals is obtained, and several routes to realizing such optical nonlinearities are discussed. We also describe two approaches for realizing tunable or reconfigurable negative-zero-positive index materials: (1) planar nano-structured frequency selective surfaces [FSS] containing nematic liquid crystals; (2) core-shell nano-spheres randomly distributed in bulk nematic liquid crystal matrix. Such metamaterials can be designed for applications in the visible-infrared, as well as Terahertz and microwave regimes. These liquid crystalline meta-materials are capable of supra-nonlinearities characterized by refractive index changing coefficients of over 1 cm 2 /watt and microseconds response times.
A tele-microrobot for manipulation and dynamic mechanical testing of single living cells (2003)

A high-performance parallel-drive microrobot has been developed for manipulation, surgery, and dynamic mechanical testing of single living muscle cells. The microrobot has two limbs which more in overlapping spherical workspaces of 1 mm diameter with minimum open-loop and closed-loop movements of 1 nm and 10 nm, respectively. Under nonlinear model-based control the limbs can move at up to 2 m/s relative to each other. Ferroelectric polymer microgrippers have been fabricated to facilitate cell manipulation. The microrobot has a three-dimensional laser vision system with a resolution of 50 to 100 nm. Volume images containing magnitude, phase, polarization, and spectral information can be acquired. The microrobot incorporates facilities to keep single living cells alive for long periods. A macro version of the microrobot has been built to allow force-reflecting teleoperation of the microrobot. The tele-microrobot system constitutes a mechanical microscope in which microscopic objects can be felt. The macro-interface also enables the operator to feel mechanical continuum models. A parallel computation and control computer has been designed to meet the substantial numerical requirements of the tele-microrobot system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Efficacy and safety results of GX-188E, a therapeutic DNA vaccine, combined with pembrolizumab administration in patients with HPV 16- and/or 18- positive advanced cervical cancer: Phase II interim analysis results (KEYNOTE-567). (2021)

5511 Background: Pembrolizumab was approved for the treatment of recurrent or metastatic cervical cancer, based on 14.3% of objective response rate (ORR) in patients with PD-L1 expression (CPS≥1). GX-188E vaccination has been shown to induce human papillomavirus (HPV) E6- and E7-specific T-cell responses. We aimed to investigate whether a combination of GX-188E (Tirvalimogene teraplasmid) therapeutic DNA vaccine plus pembrolizumab showed antitumor activity against recurrent or advanced cervical cancer. Methods: In this open-label, single-arm, phase 2 trial, patients with recurrent or advanced cervical cancer, who were aged over 18 years with ECOG PS of 0 or 1, HPV-16 or HPV-18 and histologically confirmed positive cervical cancer, and who had progressed after standard-of-care therapy were recruited from nine hospitals in South Korea. Patients received intramuscular 2 mg GX-188E at weeks 1, 2, 4, 7, 13, 19, and optional dose at week 46, and intravenous pembrolizumab 200 mg every 3 weeks for up to 2 years or until disease progression. The primary endpoint was the Best Overall Response Rate assessed by the investigator using RECIST version 1.1. Results: To date, a total of 52 patients have been enrolled and received at least one study treatment, and this interim analysis was performed after obtaining at least one post-baseline tumor assessment data from 48 patients. Median age was 52 (range, 27-79) years and 46.2% had ECOG PS 1. At the data cutoff date on January 11, 2021, median follow-up duration was 6.2 months (range; 1.7- 24.2 months). According to investigator evaluation, 15 (31.3%) of 48 patients achieved best overall response; 5 (10.4 %) patients had a complete response (CR) and 10 (20.8 %) had a partial response (PR). Especially, this combination treatment showed higher response rate, 48.0 %, in patients with PD-L1 positive, HPV-16 and squamous cell carcinoma. Median PFS was 4.1 months (range; 1.3-24.2) and median OS was 16.7 months (range; 1.7-24.2). In this clinical trial with cervical cancer patients, GX-188E in combination with pembrolizumab has shown an improved median PFS and OS than the monotherapy of pembrolizumab (KEYNOTE-158). 17 (32.7%) of 52 patients had treatment-related adverse events of any grade and two (3.8%) had grade 3 or 4 treatment-related adverse events; increased aspartate aminotransferase or alanine aminotransferase. No treatment-related deaths were reported. Conclusions: GX-188E vaccine combined with pembrolizumab in recurrent/advanced cervical cancer was safe and tolerable, and showed an enhanced clinical response rate compared with pembrolizumab alone in particular in patients with PD-L1 positive, HPV-16 and squamous cell carcinoma. The combination therapy could represent a new potential treatment option for this patient population. Clinical trial information: NCT03444376.
Methylibium petroleiphilum gen. nov., sp. nov., a novel methyl tert-butyl ether-degrading methylotroph of the Betaproteobacteria (2006)

A Gram-negative, rod-shaped, motile, non-pigmented, facultative aerobe that grew optimally at pH 6.5 and 30 degrees C (strain PM1T) was isolated for its ability to completely degrade the gasoline additive methyl tert-butyl ether. Analysis of the 16S rRNA gene sequence indicated that this bacterium was a member of the class Betaproteobacteria in the Sphaerotilus-Leptothrix group. The 16S rRNA gene sequence identity to other genera in this group, Leptothrix, Aquabacterium, Roseateles, Sphaerotilus, Ideonella and Rubrivivax, ranged from 93 to 96 %. The chemotaxonomic data including Q-8 as the major quinone, C16 : 1omega7c and C16 : 0 as the major fatty acids and a DNA G+C content of 69 mol%, support the inclusion of strain PM1T in the class Betaproteobacteria. It differed from other members of the Sphaerotilus-Leptothrix group by being a facultative methylotroph that used methanol as a sole carbon source, and by also being able to grow heterotrophically in defined media containing ethanol, toluene, benzene, ethylbenzene and dihydroxybenzoates as sole carbon sources. On the basis of the morphological, physiological, biochemical and genetic information, a new genus and species, Methylibium petroleiphilum gen. nov., sp. nov., is proposed, with PM1T (=ATCC BAA-1232T=LMG 22953T) as the type strain.