gebhart/patrepeval huggingface dataset:
Chromosomal imbalance in the progression of high-risk non-muscle invasive bladder cancer (2009)

Chromosomal instability (CI) was associated with "high risk" tumors (stage T1 or high-grade), but did not predict subsequent progression. Recurrences after "high-risk" tumors had fewer chromosomal alterations, but there was no association with the risk of progression in this group either. Thus, the prediction of progression of "high risk" non-muscle invasive bladder tumors using chromosomal changes is difficult. Loss of chromosome 8p11 may play a role in the progression process. About 25% of the "high risk" tumors were chromosomal stable.
Mold Technologies (2007)

No AccessInjection Mold Design EngineeringAug 2007Mold TechnologiesDavid O. KazmerDavid O. Kazmerhttps://doi.org/10.3139/9783446434196.013SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2007Pages: 343-388Print ISBN: 978-3-446-41266-8eISBN: 978-3-446-43419-6 Copyright & Permissions© 2007 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
One-Dimensional Self-Assembly of Alkoxy-Capped Silicon Nanoparticles (2006)

We demonstrate here a novel method for self-assembling in dimensional alignment the alkoxy-capped silicon nanoparticles synthesized through a room-temperature chemical route. The alkoxy-capped silicon nanoparticles were prepared via a reduction of silicon tetrachloride with sodium-naphthalide and subsequent surface capsulation with 1-octanol monolayers. In the present method, a sublimation process, which was employed as a final purification process for removing the residual naphthalene, influenced significantly on the final morphology of the resultant nanoparticles. Scanning transmission electron microscope (STEM) confirmed the spherical nanoparticles on a holey carbon grid after sublimation process, while only the fibril-like morphology just before sublimation process. In the former sample, the resultant particle size was measured by STEM to be about 9.5 nm +/- 3.4 nm. On the other hand, in the latter sample, the fibril-like structures were shaped by self-assembled silicon nanoparticles in dimensional alignment. The diameters and lengths of the fibril-like assemblies were approximately measured to be 10 to 20 nm and over 5 microm, respectively.
Comparison of cystic fibrosis structural lung disease detected by inspiratory and expiratory chest CT scans in infants and preschool children (2011)

Introduction: Chest computed tomography (CT) reveals early cystic fibrosis (CF) structural lung disease. Typically, bronchiectasis (Bx) is assessed on inspiration and gas trapping on expiration, but in older children expiratory scans reliably detect both, reducing radiation exposure.

Objective: To compare the presence and extent of CF structural lung disease detected on volumetric inspiratory and expiratory scans in young children.

Methods: 38 children with CF age 1-5 years underwent inspiratory and expiratory volumetric chest CT. De-identified scans were assessed in random order by 2 observers using the Brody II score. Intraclass correlation coefficients (ICC) and Bland-Altman plots using mean scores determined agreement between expiratory and inspiratory scans.

Results: There was substantial agreement between mean Brody II component scores from inspiratory and expiratory scans (ICC range 0.637 to 0.866). For Bx, the ICC was 0.864, however, there was a systematic bias evident on Bland-Altman plot as shown, with consistently higher scores on inspiration. Further, analysis of binary outcomes (presence/absence of Bx) indicated that Bx was not demonstrated on the expiratory scan in 40% of subjects when demonstrated on the inspiratory scan.

![Figure][1] 



Conclusions: In early CF Bx, the presence and extent of Bx is underestimated with expiratory scans alone compared with inspiratory scans.

 [1]: pending:yes
Effect of DNA molecular weight, temperature, and magnetic field strength on the phosphorus-31 NMR results of DNA complexed with ethidium (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of DNA molecular weight, temperature, and magnetic field strength on the phosphorus-31 NMR results of DNA complexed with ethidiumW. David Wilson, Rebecca A. Keel, and Yitbarek H. MariamCite this: J. Am. Chem. Soc. 1981, 103, 20, 6267–6269Publication Date (Print):October 1, 1981Publication History Published online1 May 2002Published inissue 1 October 1981https://pubs.acs.org/doi/10.1021/ja00410a070https://doi.org/10.1021/ja00410a070research-articleACS PublicationsRequest reuse permissionsArticle Views68Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Plasma chemical behaviour of reactants and reaction products during inductively coupled CF4plasma etching of SiO2 (2009)

A two-dimensional fluid model has been developed to study plasma chemical behaviour of etch products as well as reactants during inductively coupled CF4 plasma etching of SiO2. The plasma fluid model consisted of Maxwell's equations, continuity equations for neutral and charged species including gas-phase and surface reactions and an energy balance equation for electrons. The surface reaction model assumed Langmuir adsorption kinetics with the coverage of fluorine atoms, fluorocarbon radicals and polymers on SiO2 surfaces. Numerical results indicated that etch product species occupy a significant fraction of reactive ions as well as neutrals in the reactor chamber during etching, which in turn leads to a change in plasma and surface chemistry underlying the processing. In practice, the density of SiF4 was typically about 10% of that of the feedstock CF4, being comparable to that of the most abundant fluorocarbon radical CF2; moreover, the density of was typically about 5% of that of the most abundant fluorocarbon ion . The density and the distribution of such product species in the reactor chamber were changed by varying the ion bombardment energy on the substrate surfaces, gas pressure, mass flow rate and coil configuration, which arises in part from gas-phase reactions depending on plasma electron density and temperature. Surface reactions on the chamber walls and on the substrate also affect the product density and distribution in the reactor; in particular, the surface reactions on the SiO2 dielectric window as well as substrate surfaces were found to largely affect the product density and distribution.
Endovascular brain mapping: A strategy for intraoperative visualization of brain parenchyma functionality (2011)

Within the field of cognitive neuroscience, brain mapping strategies aim to localizeneurological function within specific regions of the human brain. The burgeoning fieldsof functional magnetic resonance imaging (fMRI) and functional electrophysiology seekto map the human brain with ever-improving resolution. However, these functionalstrategies do not enable real-time, intraoperative discrimination of functional and nonfunctionalbrain parenchyma with precise, well-defined margins, as are necessary forsurgical guidance and resection. To address the need for an intraoperative brain mappingstrategy aimed specifically at neurosurgical guidance at resection, we have developed anovel brain mapping technique that we term preoperative endovascular brain mapping(PEBM). PEBM combines a super-selective, intraarterial approach with the delivery ofvisually detectable contrast agents to identify specific regions of functional and nonfunctionalbrain before and during craniotomy for brain resections. Our novel approachaims to avoid additional postoperative neurological deficits which would occur iffunctional brain parenchyma is inadvertently injured during an aggressive resection.Endovascular brain mapping aims to preserve brain function by providing a means ofdirect volumetric surgical guidance in real-time, whereby non-functional tissues aredelineated by sharp, visible margins and can therefore be safely resected. The successfulimplementation of PEBM is highly dependent upon the proper selection and use ofimaging probes, and we have developed a number of novel multimodal chemistriesspecifically aimed at PEBM. In this chapter, we will describe the PEBM technique indetail by highlighting its use in various small animal models, as well as our ongoingdevelopment of novel imaging probes suitable for PEBM. © 2011 Nova Science Publishers, Inc. All rights reserved.
A Rapid Spin Column-Based Method to Enrich Pathogen Transcripts from Eukaryotic Host Cells Prior to Sequencing (2016)

When analyzing pathogen transcriptomes during the infection of host cells, the signal-to-background (pathogen-to-host) ratio of nucleic acids (NA) in infected samples is very small. Despite the advancements in next-generation sequencing, the minute amount of pathogen NA makes standard RNA-seq library preps inadequate for effective gene-level analysis of the pathogen in cases with low bacterial loads. In order to provide a more complete picture of the pathogen transcriptome during an infection, we developed a novel pathogen enrichment technique, which can enrich for transcripts from any cultivable bacteria or virus, using common, readily available laboratory equipment and reagents. To evenly enrich for pathogen transcripts, we generate biotinylated pathogen-targeted capture probes in an enzymatic process using the entire genome of the pathogen as a template. The capture probes are hybridized to a strand-specific cDNA library generated from an RNA sample. The biotinylated probes are captured on a monomeric avidin resin in a miniature spin column, and enriched pathogen-specific cDNA is eluted following a series of washes. To test this method, we performed an in vitro time-course infection using Klebsiella pneumoniae to infect murine macrophage cells. K. pneumoniae transcript enrichment efficiency was evaluated using RNA-seq. Bacterial transcripts were enriched up to ~400-fold, and allowed the recovery of transcripts from ~2000-3600 genes not observed in untreated control samples. These additional transcripts revealed interesting aspects of K. pneumoniae biology including the expression of putative virulence factors and the expression of several genes responsible for antibiotic resistance even in the absence of drugs.
Impact of a novel inflammation-based prognostic system on patients undergoing surgery for hepatocellular carcinoma: A retrospective study of 398 Japanese patients. (2010)

4111 Background: Few studies have investigated the Glasgow Prognostic Score (GPS) in patients with hepatocellular carcinoma (HCC). Methods: To compare the prognostic value of the GPS and Cancer of the Liver Italian Program (CLIP) score in patients undergoing surgery for HCC. Kaplan-Meier and uni- and multivariate analyses were performed to compare the GPS with the CLIP score. Results: Three hundred ninety-eight patients were evaluated retrospectively. Kaplan-Meier analysis and log rank test revealed that a higher GPS was associated with overall survival after surgical treatment of HCC (p < 0.001) as well as CLIP score (p < 0.001). In addition, GPS can classify not only patients with HCC (p < 0.001) but also such patients with lower CLIP score (p < 0.001) into three independent groups. Univariate analyses using clinico-laboratory factors selected GPS (odds ratio, 2.994; 95% CI, 1.372-6.534; p = 0.006) as one of the predictive factors associated with overall survival after surgical treatment of HCC, as well as the CLIP score (odds ratio, 2.075; 95% CI, 1.295-3.326; p = 0.002). Multivariate analysis using these two scoring system disclosed that both GPS (odds ratio, 2.500; 95% CI, 1.124-5.561; p = 0.025) and CLIP score (odds ratio, 1.886; 95% CI, 1.164- 3.056; p = 0.010) were associated with overall survival after surgical treatment of HCC. Conclusions: GPS is not only a simple and convenient system for preoperative classification of patients with HCC, but also an important predictor of overall survival after surgical treatment of HCC. No significant financial relationships to disclose.
Sequential Infiltration Synthesis of Electronic Materials: Group 13 Oxides via Metal Alkyl Precursors (2019)

The sequential infiltration synthesis (SIS) of group 13 indium and gallium oxides (In2O3 and Ga2O3) into poly(methyl methacrylate) (PMMA) thin films is demonstrated using trimethylindium (TMIn) and trimethylgallium (TMGa), respectively, with water. In situ Fourier transform infrared (FTIR) spectroscopy reveals that these metal alkyl precursors reversibly associate with the carbonyl groups of PMMA in analogy to trimethylaluminum (TMAl), however, with significantly lower affinity. This is demonstrated to have important kinetic consequences that dramatically alter the synthetic parameters required to achieve material growth. Ab initio density functional theory simulations of the methyl methacrylate monomer with group 13 metal alkyls corroborate association energy that is 3× greater for TMAl than for either TMIn or TMGa. As a consequence, the kinetics of activated diffusion within the film is observed to be far more rapid for TMIn and TMGa than for TMAl. Spectroscopic ellipsometry and scanning electron microscopy, in combination with Hall effect measurements of SIS-derived In2O3 films, demonstrate that SIS enables rapid growth of thin films with continuous electrically conductive pathways after postannealing. Notably, SIS with TMIn and water enables the growth of In2O3 at 80 °C, well below the onset temperature of atomic layer deposition (ALD) using these precursors.
Bootstrapping RFC3118 Delayed DHCP Authentication Using EAP-based Network Access Authentication (2008)

The DHCP authentication extension (RFC 3118) cannot be widely deployed
due to lack of a key agreement protocol. This document outlines how
EAP-based network access authentication mechanisms can be used to
establish bootstrap keying material that can be used to subsequently
use RFC 3118 security.
‘Under the spelling wall’: language and style (2013)

Abstract This chapter explores Thomas' process style in detail, using ideas drawn from structuralism and poststructuralism. It suggests that Thomas' love of the linguistic ‘remainder’ is unexampled in English poetry of the time, and unleashed a gleeful, despairing linguistic excess, by way of response to various forms of determinist threat and, above all, generational fears of world war, thus creating a kind of revolutionary and materialist mysticism at odds with the Left's usual social realist response and the discursive style and instrumental language use that it required.
Dieckol Suppresses CoCl2-induced Angiogenesis in Endothelial Cells (2014)

Dieckol is a polyphenol compound isolated from brown algae that has anti-oxidant, anti-inflammatory, and anti-tumor activity. We examined the anti-angiogenic effects of dieckol in endothelial cells under hypoxic conditions. Treatment with <TEX>$CoCl_2$</TEX>, a hypoxic mimetic agent, increased proliferation, adhesion, migration, and tube formation in HUVECs, as well as vessel sprouting in rat aortic rings, which correlated well with increased expression of hypoxia-inducible factor 1-alpha (<TEX>$HIF1{\alpha}$</TEX>) and <TEX>${\beta}1$</TEX>-integrin. Dieckol suppressed <TEX>$CoCl_2$</TEX>-induced adhesion, migration, and tube formation in HUVECs and vessel sprouting in rat aortic rings. Dieckol treatment decreased <TEX>$CoCl_2$</TEX>-induced overexpression of <TEX>$HIF1{\alpha}$</TEX> and its downstream signaling molecules, including <TEX>${\beta}1$</TEX>-integrin/Fak, Akt/eNOS, and p38 MAPK. These results suggest that dieckol is a novel angiogenesis inhibitor and a potential treatment for angiogenesis-dependent diseases in humans, such as malignant tumors.
CFD AND FLOW VISUALIZATION ANALYSES OF CRITICAL GAPS IN A ROTARY PUMP, WITH IN VIVO CORROBORATION (2004)

PURPOSE: HeartMate® 111 is a compact implantable centrifugal LVAD featuring a magnetically levitated impeller. The goal of this analysis is to examine the degree of washing that occurs in the gaps between the rotor and the rotor well surfaces. METHODS: CFD and flow visualization results were compared to pumps explanted from calves (> 10 days implant duration). Specifically, the rotor well surfaces were examined for red thrombus. RESULTS CFD, along with flow visualization, demonstrated pressure-driven backflows in the rotor well gaps. In addition, CFD showed a wandering vortex in rotor central core. Both these features could produce beneficial surface washing. Observations of thrombus-free surfaces in explanted pumps support this hypothesis; out of 14 in vivo studies, 10 explanted pumps run within the design flow range (2-10 L/min) had no red thrombi. The remaining 4 had concomitant anomalies related to protracted low flow (<2 L/min). CONCLUSIONS Actively controlled magnetic levitation allows for considerably larger gaps than can be afforded by other bearing configurations. These gaps create recirculation paths that provide adequate washing of the titanium surfaces of the rotor well. In vivo studies have corroborated the predictions of CFD and flow visualization studies, demonstrating low incidence of red thrombi in these critical gaps.
SEVERE HYPERGLYCEMIA, RENAL DAMAGE, AND LOW SERUM TESTOSTERONE ARE INSUFFICIENT IN THE ABSENCE OF OBESITY TO CAUSE CORPORAL VENO-OCCLUSIVE DYSFUNCTION (CVOD) IN A RAT MODEL OF TYPE 2 DIABETES (2009)

You have accessJournal of Urology1 Apr 2009SEVERE HYPERGLYCEMIA, RENAL DAMAGE, AND LOW SERUM TESTOSTERONE ARE INSUFFICIENT IN THE ABSENCE OF OBESITY TO CAUSE CORPORAL VENO-OCCLUSIVE DYSFUNCTION (CVOD) IN A RAT MODEL OF TYPE 2 DIABETES Istvan Kovanecz, Gaby Nolazco, Monica G Ferrini, Steve Rivera, Dolores Vernet, Jacob Rajfer, and Nestor F Gonzalez-Cadavid Istvan KovaneczIstvan Kovanecz More articles by this author , Gaby NolazcoGaby Nolazco More articles by this author , Monica G FerriniMonica G Ferrini More articles by this author , Steve RiveraSteve Rivera More articles by this author , Dolores VernetDolores Vernet More articles by this author , Jacob RajferJacob Rajfer More articles by this author , and Nestor F Gonzalez-CadavidNestor F Gonzalez-Cadavid More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)60855-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "SEVERE HYPERGLYCEMIA, RENAL DAMAGE, AND LOW SERUM TESTOSTERONE ARE INSUFFICIENT IN THE ABSENCE OF OBESITY TO CAUSE CORPORAL VENO-OCCLUSIVE DYSFUNCTION (CVOD) IN A RAT MODEL OF TYPE 2 DIABETES." The Journal of Urology, 181(4S), p. 300 © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 4SApril 2009Page: 300 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetrics Author Information Istvan Kovanecz More articles by this author Gaby Nolazco More articles by this author Monica G Ferrini More articles by this author Steve Rivera More articles by this author Dolores Vernet More articles by this author Jacob Rajfer More articles by this author Nestor F Gonzalez-Cadavid More articles by this author Expand All Advertisement PDF downloadLoading ...
Toward Thermally, Oxidatively, and Spectrally Stable Polyfluorene-Based Materials: Aromatic Ether-Functionalized Polyfluorene (2009)

Two unique fluorene monomers (PTE and MTE) and polyfluorene-based homopolymers (PPTE and PMTE) containing covalently linked aromatic ether (AE) moieties were synthesized via microwave Ni(0)-mediated Yamamoto coupling reactions. The monomers and polymers demonstrated thermal stabilities, as determined by TGA, much higher than status quo poly(9,9′-dioctylfluorene) (PFO) (i.e., greater than 100 °C), and most importantly, the spectral emission remained stable after annealing in ambient and inert atmospheres. PPTE and PMTE were annealed in an N2 atmosphere at 200 °C for 72 h and at 150 °C in ambient atmosphere for 1 h showing no evidence of green emission, in stark contrast to PFO. The results show that PFs with AE moieties present in the 9-position exhibit stable blue emission.
Smooth Scalar-on-Image Regression via Spatial Bayesian Variable Selection (2012)

We develop scalar-on-image regression models when images are registered multidimensional manifolds. We propose a fast and scalable Bayes inferential procedure to estimate the image coefficient. The central idea is the combination of an Ising prior distribution, which controls a latent binary indicator map, and an intrinsic Gaussian Markov random field, which controls the smoothness of the nonzero coefficients. The model is fit using a single-site Gibbs sampler, which allows fitting within minutes for hundreds of subjects with predictor images containing thousands of locations. The code is simple and is provided in less than one page in the Appendix. We apply this method to a neuroimaging study where cognitive outcomes are regressed on measures of white matter microstructure at every voxel of the corpus callosum for hundreds of subjects.
Sensor Placement for Closed-Loop Flow Control of a "D" Shaped Cylinder Wake (2004)

The effectiveness of a sensor configuration, based solely on body surface pressure readings, for feedback flow control of the wake of a D shaped cylinder is investigated by DNS. The research is aimed at suppressing unsteady loads resulting from the von Karman vortex shedding in the wake of bluff bodies at a Reynolds number range of 100-1000. The design of sensor number and placement was based on data from a laminar direct numerical simulation of the Navier Stokes equations for the baseline condition. A low-dimensional Proper Orthogonal Decomposition (POD) procedure was applied to the pressure and stream-wise velocity of the flow field. The sensor placement was based on the intensity of the spatial Eigen-functions obtained by applying POD to 286 surface pressures. The numerically generated data was comprised of 100 snapshots taken from the flow regime that corresponds to steady state vortex shedding. A Linear Stochastic Estimator (LSE) was employed to map the pressure signals from the body mounted sensors to the temporal coefficients of the reduced order model of the wake flow field in order to provide accurate yet compact estimates of the lowdimensional states. For a ten sensor configuration, results show that the root mean square estimation error of the estimates of the first two modes is within 1-3% of the desired values and for the third mode it is 12-20% accurate. This level of error is acceptable for a moderately robust controller required to close the loop, based on previous investigation.