gebhart/patrepeval huggingface dataset:
Ventilation Induces Changes in Pulse Wave Transit Time in the Pulmonary Artery (2023)

Pulse wave transit time (PWTT) shortens as pulmonary artery pressure (PAP) increases and was therefore suggested as a surrogate parameter for PAP. The aim of this analysis was to reveal patterns and potential mechanisms of ventilation-induced periodic changes in PWTT under resting conditions. To measure both PWTT and PAP in five healthy pigs, two pulmonary artery Mikro-Tip™ catheters were inserted into the pulmonary vasculature: one with the tip placed in the pulmonary artery trunk, and a second one placed in a distal segment of the pulmonary artery. Animals received pressure-controlled mechanical ventilation. Ventilation-dependent changes were seen in both variables, PWTT and mean PAP; however, changes in PWTT were not synchronous with changes in PAP. Thus, plotting the value of PWTT for each heartbeat over the respective PAP revealed a characteristic hysteresis. At the beginning of inspiration, PAP rose while PWTT remained constant. During further inspiration, PWTT started to decrease rapidly as mPAP was about to reach its plateau. The same time course was observed during expiration: while mPAP approached its minimum, PWTT increased rapidly. During apnea this hysteresis disappeared. Thus, non-synchronous ventilation-induced changes in PWTT and PAP were found with inspiration causing a significant shortening of PWTT. Therefore, it is suggested that the respiratory cycle should be considered when using PWTT as a surrogate for PAP.
Sheet Metal Formability Analysis for Anisotropic Materials (2004)

Sheet metal formability is conventionally assessed in a two dimensional plot of principal strains or stresses in comparison to a forming limit curve. This method implicitly assumes that the forming limit is isotropic in the plane of the sheet, an assumption that is intrinsically inconsistent with the use of material models that are anisotropic. Since the trend today is to utilize models with full anisotropy in order to more accurately capture the physics of material behavior, the issue of anisotropy of forming limits must also be addressed. The challenge is that the forming limit is no longer defined by a curve but requires the definition of a surface in strain or stress space, and therefore it is no longer appropriate to view these limits with the convenience of the conventional two dimensional diagrams. Furthermore, recent developments in the characterization of sheet forming limits under nonproportional loading suggest that is advantageous to view forming limit behavior in terms of stresses rather than strains, a view that is adopted in this paper. A solution to the challenge of assessing formability for an anisotropic material is proposed and illustrated using an analysis of the 2‐Stage Forming Benchmark highlighted in the Numisheet ’99 Conference.
Abstract 2701: Molecular profiling to assess the immune response to neoadjuvant SABR in early breast cancer (2021)

Abstract Radiation therapy is used successfully in the treatment of breast cancer. Stereotactic radiation therapy (SBRT) is well established in the treatment of lung cancer, brain metastases and various other metastatic sites. Localized radiotherapy can promote dendritic cells maturations and activation and enhances phagocytosis of cells by antigen-presenting cells (APCs) increased presentation of tumor-associated antigenic peptides, and T cells being primed from naïve towards memory phenotypes In this study we evaluated the ability to implement a three fraction SBRT regimen for low-risk primary carcinoma of the breast prior to lumpectomy and profiled the immune microenvironment using NanoString's GeoMx Digital Spatial Profiling (DSP) platform and we performed NanoString gene expression profiling using the Human v.1.1 PanCancer immune profiling panel. NanoString's DSP platform was used to analyze 25 patient samples from the SIGNAL 2.0 clinical trial. For analysis, region of interest were selected comparing the tumor microenvironment (TME, CD45+ve) and tumor (pan cytokeratin) in pre and post treated FFPE slides. A panel of 60-antibodies were analyzed in each region. For gene expression profiling total RNA was extracted from the frozen tissue and the human V.1.1 PanCancer Immune Profiling Panel was used. We observed notable differences in the immune microenvironment gene expression patterns in samples pre- and post-treatment. We identified a total of 175 differentially expressed genes (DEGs) using a 5% adjusted p-value across the entire patient population regardless of which radiation arm. Pathway analysis identified genes associated with activation of immune response, signaling by interleukins and adaptive immune response were significantly changed in the post treatment samples. Deconvolution of the immune cell mRNA gene expression data demonstrated that there were significant changes in the cellular composition after radiotherapy. There were significant increase in expression levels of macrophages, dendritic cells, neutrophils and CD8 T cells post radiation treatment. In conclusion we have demonstrated through proteomic and transcriptomic profiling, SBRT elicits an immune response with increases in the innate response. Citation Format: Melanie Spears, Vida Talebian, Linda Liao, Megan Hopkins, Kalan Lynn, Michael Lock, Anat Kornecki, John M. Bartlett, Muriel Brackstone. Molecular profiling to assess the immune response to neoadjuvant SABR in early breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 2701.
Reaction-diffusion memory unit: Modeling of sensitization, habituation and dishabituation in the brain (2019)

We propose a novel approach to investigate the effects of sensitization, habituation and dishabituation in the brain using the analysis of the reaction-diffusion memory unit (RDMU). This unit consists of Morris-Lecar-type sensory, motor, interneuron and two input excitable cables, linked by four synapses with adjustable strength defined by Hebbian rules. Stimulation of the sensory neuron through the first input cable causes sensitization by activating two excitatory synapses, C1 and C2, connected to the interneuron and motor neuron, respectively. In turn, the stimulation of the interneuron causes habituation through the activation of inhibitory synapse C3. Likewise, dishabituation is caused through the activation of another inhibitory synapse C4. We have determined sensitization-habituation (BSH) and habituation-dishabituation (BHDH) boundaries as functions between synaptic strengths C2 and C3 at various strengths of C1 and C4. When BSH and BHDH curves shift towards larger values of C2, the RDMU can be easily inhibited. On the contrary, the RDMU can be easily sensitized or dishabituated if BSH and BHDH curves shift towards smaller values of C2. Our numerical simulations readily demonstrate that higher values of the Morris-Lecar relaxation parameter, greater leakage and potassium conductances, reduced length of the interneuron, and higher values of C1 all result in easier habituation of the RDMU. In contrast, we found that at higher values of C4 the RDMU becomes significantly more prone to dishabituation. Based on these simulations one can quantify BSH and BHDH curve shifts and relate them to particular neural outcomes.
Genome-wide characterization and expression profiling of B3 superfamily during flower induction stage in pineapple ( Ananas comosus L.) (2020)

Abstract The B3 superfamily is a plant-specific family, which involves in growth and development process. By now, the identification of B3 superfamily in pineapple ( Ananas comosus ) has not reported. In this study, 57 B3 genes were identified and further phylogenetically classified into five subfamilies, all genes contained B3 domain. Chromosomal localization analysis revealed that 54 of 57 AcB3 genes were located on 21 chromosomes.Collinearity analysis indicated that the segmental duplication was the main event in the evolution of B3 gene superfamily and most of them were under purifying selection. Moreover, there were 7 and 39 pairs of orthologous B3s were identified between pineapple and Arabidopsis or rice, respectively, which indicated the closer genetic relationship between pineapple and rice. Most genes had cis -element of abscisic acid, ethylene, MeJA, light, and abiotic stress. qRT-PCR showed that the expression level of most AcB3 genes were up-regulated within 1 d after ethephon treatment and expressed high level in flower bud differentiation period in stem apex. This study provide a comprehensive understanding of AcB3s and a basis for future molecular studies of ethephon induced pineapple flowering.
A 65-nm CMOS 8-GHz injection locked oscillator for HDR UWB applications (2008)

In this paper, an 8 GHz 16 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> sub-harmonic injection-locked oscillator based on LC-oscillators and pulse generators is presented. It has been fully implemented in a VLSI 65 nm CMOS technology from STMicroelectronics and is dedicated to a double-loop frequency synthesizer. Under a nominal power supply of 1.2 V, the ILO core dissipates 20mA (without buffers) for a measured phase noise of -107 dBc/Hz at 100 kHz offset from the 8 GHz carrier. It also provides a synchronization bandwidth of 350 MHz, thanks to a double synchronization network.
High Magnetization Helical Carbon Nanofibers Produced by Nanoparticle Catalysis (2006)

Helical carbon nanofibers were synthesized by means of acetylene pyrolysis at 450 degrees C using Fe nanoparticles as catalyst. There is no need to modify the Fe nanoparticles by a chiral reagent. The carbon nanofibers generated are crystalline and symmetric, with the (110) plane of Fe particle being the mirror plane. There would be a change in the shape of the nanofibers if the temperature at the beginning or during the synthesis were altered. Compared to the helical carbon nanofibers reported elsewhere in the literature, our samples show higher magnetization.
Reduced CD62L Expression on T Cells and Increased Soluble CD62L Levels Predict Molecular Response to Tyrosine Kinase Inhibitor Therapy in Early Chronic-Phase Chronic Myelogenous Leukemia (2017)

Purpose Immunologic surveillance of minimal residual disease in chronic myelogenous leukemia (CML) may be relevant for long-term control or cure of CML. Little is known about immune-modulatory effects of nilotinib in vivo, potentially predicting response to therapy. Patients and Methods A prospective and comprehensive flow cytometry-based immunomonitoring program paralleled the ENEST1st clinical study, investigating 52 nilotinib-naïve patients with chronic-phase CML. Data were verified in independent validation cohorts. Results T cells of patients with CML at diagnosis expressed low l-selectin (CD62L) levels, which was not a result of proportional aberrations of T-cell subsets. Low numbers of CD62L-expressing CD4<sup>+</sup> and CD8<sup>+</sup> T cells correlated with higher Sokal score, increased spleen size, and high leukocyte and peripheral-blood blast counts. At month 6 during nilotinib therapy, CD62L expression returned to levels of healthy individuals. The level of CD62L loss on T cells directly correlated with the extent of soluble CD62L (sCD62L) elevation. In parallel, the proteolytic activity of tumor necrosis factor α-converting enzyme (TACE; ADAM17, CD156b), the metalloproteinase shedding CD62L, was increased at diagnosis and significantly decreased during nilotinib treatment. High CD62L<sup>+</sup> expression on both CD4<sup>+</sup> and CD8<sup>+</sup> T cells and, vice versa, low sCD62L levels at CML diagnosis were linked to superior molecular responses. These findings were corroborated in independent validation cohorts. Conclusion We demonstrate the prognostic impact of CD62L shedding from T cells and increased sCD62L plasma levels at CML diagnosis on molecular response to tyrosine kinase inhibitor therapy in early chronic-phase CML. Functionally, decreased CD62L may be a consequence of increased TACE-mediated CD62L cleavage and potentially impairs immune-cell function. Larger prospective studies are ongoing to confirm the prognostic relevance of this finding.
Li4Ti5O12 Material Prepared by Mechano Chemical Activation: Structure and Electrochemical Performance (2006)

Abstract not Available.
Supplementary Figure Legends 1-7 from <i>Neuropilin-1</i> Stimulates Tumor Growth by Increasing Fibronectin Fibril Assembly in the Tumor Microenvironment (2023)

&lt;p&gt;PDF file - 28K&lt;/p&gt;
Energy Management Strategies for Series-Parallel Hybrid Electric Vehicles Considering Fuel Efficiency and Degradation of Lithium-Ion Batteries (2023)

&lt;div&gt;Lithium-ion batteries are the most crucial component of hybrid electric vehicles (HEVs) with respect to cost and performance. In this article, a new energy management strategy (EMS) is developed that improves fuel efficiency (FE) and suppresses the degradation of the battery. A hybridized two-layer algorithm that combines multi-objective nonlinear model predictive control (NMPC) with a rule-based (RB) algorithm is proposed as a new EMS that is called RB-NMPC. The RB-NMPC is designed to optimize the torque split between the engine and electric motors while maintaining the maximum and minimum constraints of each component. The proposed EMS is incorporated into control-oriented vehicle models, and their performances are analyzed for different driving cycles by comparing with RB, dynamic programming (DP), and NMPC. In addition, the RB-NMPC algorithm is applied for two different powertrain configurations of HEV, P0P2 and P1P2 configurations for both an Urban Dynamometer Driving Schedule (UDDS) and a Highway Fuel Economy Test (HWFET). For P0P2, the results show that RB-NMPC outperforms other methods for UDDS with an FE that is 4.7% higher than that of RB and is the closest to that of DP, which is an optimal standard that is limited for real-time application due to its complexity among others. The capacity loss of the battery using RB-NMPC is 19.1% less than that using DP when applied to the UDDS. The FE of P1P2 is higher than that of P0P2, but the similar capacity fade is comparable. RB-NMPC shows the lowest capacity loss for both P0P2 and P1P2 configurations. Parallel comparisons are performed for the HWFET. For the HWFET, the FEs of P0P2 and P1P2 are similar. However, the capacity fades by RB-NMPC are 16.3% and 67.0% reduced compared to that by DP for P0P2 and P1P2, respectively. Finally, to verify the effectiveness of the RB-NMPC in reducing battery aging, the currents from DP and RB-NMPC EMSs are applied to pouch-type lithium-ion batteries and tested for multiple UDDSs using a battery test station. The results demonstrate that the RB-NMPC can effectively reduce battery aging.&lt;/div&gt;
Ferroelectret-based flexible transducers: A strategy for acoustic levitation and manipulation of particles (2020)

Advanced acoustic levitation devices featuring flexible, lightweight, wide bandwidth, and film-like transducers based on ferroelectrets are designed and fabricated for sophisticated manipulation of particles in a simple way. Owing to the unique properties of ferroelectret films, such as high piezoelectric activity, very small acoustic impedance, a relatively large damping ratio, flexibility, a large area, and small density, the levitator reported features a wider bandwidth compared to ceramic-based levitators. The transportation of levitated particles is achieved by deformation of the film transducer, which represents a different and promising concept for this task.
Principles of Communication Systems Simulation with Wireless Applications (2003)

The hands-on, example-rich guide to modeling and simulating advanced communications systems.Simulation is an important tool used by engineers to design and implement advanced communication systems that deliver optimal performance. This book is a hands-on, example-rich guide to modeling and simulating advanced communications systems. The authors take a systems-level approach, integrating digital communications, channel modeling, coding, elementary statistical estimation techniques, and other essential facets of modeling and simulation. This is the first book to present complete simulation models built with MATLAB that can serve as virtual laboratories for predicting the impact of system design changes. Coverage includes: Role of simulation in communication systems engineering Simulation approaches and methodologies Signal and system representations, filter models, noise generation, Monte Carlo simulation, and postprocessing Advanced techniques for modeling and simulating nonlinear and time-varying systems Waveform level and discrete channel models Performance estimation via Monte Carlo simulation Semianalytic simulation techniques Variance reduction techniques Co-channel interference in wireless communication systems, and more The authors also present detailed case studies covering phase-locked loops, CDMA systems, multichannel nonlinear systems, as well as a start-to-finish simulation of an advanced cellular radio system.Prentice Hall Series in Communications Engineering & Emerging Technologies, Theodore S. Rappaport, Editor
Magnetic Properties of bcc FeRh1-xMx Systems. (1994)

The magnetic properties of ordered bcc FeRh1-xMx alloys (M=Fe, Co, Ni, Pd, Ir and Pt) were studied, and the correlations among the antiferromagnetic-ferromagnetic transition temperature T0, the Curie temperature, magnetization, and lattice constant were investigated. Substitution of the 3d element M for Rh diminishes the transition temperature T0, since the large magnetic moment of the M atom stabilizes the ferromagnetism. Moreover, first-order antiferromagnetic-paramagnetic transition was observed in an FeRh1-xIrx system. The mechanism of those first-order phase transitions can be explained phenomenologically by introducing magneto-volume coupling into the model based on the SCR theory. The ground state properties of FeRh and FeRh1-xPdx are well explained by first-principle band calculations based on the linearized muffin-tin orbital method.
Model‐informed pediatric dose selection of marzeptacog alfa (activated): An exposure matching strategy (2023)

Marzeptacog alfa (activated) (MarzAA) is an activated recombinant human rFVII variant intended for subcutaneous (s.c.) administration to treat or prevent bleeding in individuals with hemophilia A (HA) or B (HB) with inhibitors, and other rare bleeding disorders. The s.c. administration provides benefits over i.v. injections. The objective of the study was to support the first-in-pediatric dose selection for s.c. MarzAA to treat episodic bleeding episodes in children up through 11 years in a registrational phase III trial. Assuming the same exposure-response relationship as in adults, an exposure matching strategy was used with a population pharmacokinetics model. A sensitivity analysis evaluating the impact of doubling in absorption rate and age-dependent allometric exponents on dose selection was performed. Subsequently, the probability of trial success, defined as the number of successful trials for a given pediatric dose divided by the number of simulated trials (n = 1000) was studied. A successful trial was defined as outcome where four, three, or two out of 24 pediatric subjects per trial were allowed to fall outside the adult exposures after s.c. administration of 60 μg/kg. A dose of 60 μg/kg in children with HA/HB was supported by the clinical trial simulations to match exposures in adults. The sensitivity analyses further supported selection of the 60 μg/kg dose level in all age groups. Moreover, the probability of trial success evaluations given a plausible design confirmed the potential of a 60 μg/kg dose level. Taken together, this work demonstrates the utility of model-informed drug development and could be helpful for other pediatric development programs for rare diseases.
Cloned, CD117 Selected Human Amniotic Fluid Stem Cells Are Capable of Modulating the Immune Response (2011)

Amniotic fluid stem (AFS) cells are broadly multipotent, can be expanded extensively in culture, are not tumorigenic and can be readily cryopreserved for cell banking. Mesenchymal stem cells (MSC) show immunomodulatory activity and secrete a wide spectrum of cytokines and chemokines that suppress inflammatory responses, block mixed lymphocyte reactions (MLR) and other immune reactions, and have proven therapeutic against conditions such as graft-versus-host disease. AFS cells resemble MSCs in many respects including surface marker expression and differentiation potential. We therefore hypothesized that AFS cells may exhibit similar immunomodulatory capabilities. We present data to demonstrate that direct contact with AFS cells inhibits lymphocyte activation. In addition, we show that cell-free supernatants derived from AFS cells primed with total blood monocytes or IL-1β, a cytokine released by monocytes and essential in mediation of the inflammatory response, also inhibited lymphocyte activation. Further investigation of AFS cell-free supernatants by protein array revealed secretion of multiple factors in common with MSCs that are known to be involved in immune regulation including growth related oncogene (GRO) and monocyte chemotactic protein (MCP) family members as well as interleukin-6 (IL-6). AFS cells activated by PBMCs released several additional cytokines as compared to BM-MSCs, including macrophage inflammatory protein-3α (MIP-3α), MIP-1α and Activin. AFS cells also released higher levels of MCP-1 and lower levels of MCP-2 compared to BM-MSCs in response to IL-1β activation. This suggests that there may be some AFS-specific mechanisms of inhibition of lymphocyte activation. Our results indicate that AFS cells are able to suppress inflammatory responses in vitro and that soluble factors are an essential component in the communication between lymphocytes and AFS cells. Their extensive self-renewal capacity, possibility for banking and absence of tumorigenicity may make AFS cells a superior source of stable, well characterized "off the shelf" immunomodulatory cells for a variety of immunotherapies.
Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease (2018)

Targeting the Pde6δ-Rap1 interaction has promising therapeutic potential for disorders characterised by neuronal hyperactivity, such as Alzheimer's disease.
Three-phase five-level active-neutral-point-clamped converters for medium voltage applications (2013)

In this paper various five-level active-neutral-point-clamped converters (ANPCCs) are proposed. These, as for the conventional ANPCC structure, are constructed with a combination of neutral-point-clamped and floating capacitor converter technologies. Depending on the new circuit arrangement, better total semiconductor conduction losses and/or the requirement of lesser active switch part count are achievable when compared to a conventional ANPCC. Additionally, a modulation scheme providing well regulated, balanced and low voltage ripples across the dc-bus capacitors for the studied ANPCCs is presented. The voltage balancing across the phase capacitors is performed by selecting the multilevel converter redundant switching states, which results in different current direction across this device. The technique is implemented in a carrier-based PWM modulation scheme.