gebhart/patrepeval huggingface dataset:
Enhanced Pest Resistance of Maize Leaves Expressing Monocot Crop Plant-Derived Ribosome-Inactivating Protein and Agglutinin (2012)

Although many insect resistance genes have been identified, the number of studies examining their effects in combination using transgenic systems is limited. This study introduced a construct into maize containing the coding sequence for maize ribosome-inactivating protein (MRIP) and wheat germ agglutinin (WGA). Many transformants produced both the MRIP and WGA in leaves. Mature leaves expressing higher levels of these two proteins were more resistant to feeding by first-instar larvae of fall armyworms (Spodoptera frugiperda) and corn earworms (Helicoverpa zea), and the level of resistance was correlated with levels of MRIP and WGA. There was also some indication that resistance to Fusarium verticillioides was increased in the transgenic plant leaves. No statistically significant synergism or antagonism occurred between the activities of the two proteins. MRIP and WGA represent compatible class examples of food plant-derived proteins for multigene resistance to insects.
Feasibility study of defects in 157-nm resist process (2003)

In 157-nm resists, fluorine atom is added into the polymers in order to improve the transmittance at the exposure wavelength. It is considered that the fluorine atom increases the hydrophobicity of the resists and that the number of defects during development process increases. We evaluated the development defects focusing on the missing contact holes on 157-nm resists. We used different types of 157-nm resists based on such as monocyclic fluoropolymer type, tetrafluoroethylene-norbornene type, and siloxane type. A KrF and ArF resist were also studied for comparison. We measured the number of the missing contact holes for 2500nm 1:2 hole pattern exposed using a KrF stepper. The number of the missing contact holes is higher for the 157-nm resists than that for the KrF or ArF resist. The contact angle of de-ionized water on the resist film of the 157-nm resists was found to be higher than that of the KrF and ArF resists. We examined the number of missing contact holes for various types of resist polymer and the blocking level, and found that the large contact angle, which corresponds to the high hydrophobicity of the resist film, induces the large number of the missing contact holes. The origin of the missing contact holes is the micro bubbles in the developer solution induced by the dissolved nitrogen. For the 157-nm resists, the wettability between resist surface and developer solution is insufficient due to the high hydrophobicity of the resists. Therefore, the micro bubbles are not easily released from the resist surface, and the number of the micro bubbles increases. In order to reduce the number of the missing contact holes, we tried the surfactant-containing developer solution and also tried the nitrogen-degassed developer solution. In both developers, we found that the number of the missing contact holes is reduced by less than half.
Effect of Hepatic Impairment on the Pharmacokinetics and Pharmacodynamics of Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor Agonist (2023)

Cilofexor is a nonsteroidal farnesoid X receptor agonist in clinical development for treatment of nonalcoholic steatohepatitis. This work characterized the pharmacokinetics, pharmacodynamics, safety, and tolerability of cilofexor in participants with normal hepatic function or hepatic impairment (HI). Participants with stable mild, moderate, or severe HI (Child-Pugh [CP] A, B, or C, respectively, [n = 10/group]) and healthy matched controls with normal hepatic function received a single oral dose of cilofexor (30 mg for CP-A or B; 10 mg for CP-C) with a standardized meal. Overall, 56 participants received cilofexor and completed the study. Cilofexor area under the plasma concentration-time curve was 76%, 2.5-fold, and 6.3-fold higher in participants with mild, moderate, or severe HI, respectively, relative to the area under the plasma concentration-time curve in matched participants with normal hepatic function. Cilofexor unbound fraction was 38%, 2-fold, and 3.16-fold higher in participants with mild, moderate, and severe HI, respectively, relative to participants with normal hepatic function. Moderate correlations were identified between cilofexor exposure and CP score or laboratory tests components of CP score. Serum 7α-hydroxy-4-cholesten-3-one and plasma fibroblast growth factor 19 were similar in participants with mild, moderate, or severe HI and participants with normal hepatic function. Cilofexor was generally well tolerated; all cilofexor-related adverse events were mild in severity. Cilofexor can be administered to patients with mild HI without dose adjustment. Caution and dose modification are warranted when administering cilofexor to patients with moderate or severe HI.
Catalytic role of the active site histidine of porcine pancreatic phospholipase A2 probed by the variants H48Q, H48N and H48K (1999)

The catalytic contribution of His48 in the active site of porcine pancreatic phospholipase A2 was examined using site-directed mutagenesis. Replacement of His48 by lysine (H48K) gives rise to a protein having a distorted lipid binding pocket. Activity of this variant drops below the detection limit which is 10(7)-fold lower than that of the wild-type enzyme. On the other hand, the presence of glutamine (H48Q) or asparagine (H48N) at this position does not affect the structural integrity of the enzyme as can be derived from the preserved lipid binding properties of these variants. However, the substitutions H48Q and H48N strongly reduce the turnover number, i.e. by a factor of 10(5). Residual activity is totally lost after addition of a competitive inhibitor. We conclude that proper lipid binding on its own accelerates ester bond hydrolysis by a factor of 10(2). With the selected variants, we were also able to dissect the contribution of the hydrogen bond between Asp99 and His48 on conformational stability, being 5.2 kJ/mol. Another hydrogen bond with His48 is formed when the competitive inhibitor (R)-2-dodecanoylamino-hexanol-1-phosphoglycol interacts with the enzyme. Its contribution to binding of the inhibitor in the presence of an interface was found to be 5.7 kJ/mol.
All-optical wavelength conversion scheme based on 20 Gb/s RZ data (2000)

Summary form only given.High-speed all-optical wavelength converters are essential components of future wavelength division multiplexed optical networks. Semiconductor-optical-amplifier (SOA) based wavelength converters operating up to 40 Gb/s are becoming attractive because of their small size and integrability. Wavelength conversion in the SOA can be achieved either by cross-gain modulation (XGM) in a single amplifier or by cross phase modulation (XPM) in two amplifiers placed in a Mach-Zehnder interferometer (MZI). We demonstrate a hybrid scheme of a single-SOA and asymmetric MZI (AMZI) for wavelength conversion of 20 Gb/s RZ format data.
Watt-level, high-repetition-rate, mid-infrared pulses generated by wavelength conversion of an eye-safe fiber source (2006)

We report on a mid-infrared (mid-IR) source consisting of an approximately 10 W average-power, linearly polarized 1.54 microm wavelength pulsed fiber source pumping an optical parametric oscillator. From this source, we obtained average power in excess of 1 W in the 3.8-4.0 microm wavelength range at a pulse repetition frequency of 100 kHz. With a slightly different setup, we also achieved an average power of 0.25 W at 4.5 microm wavelength. To our knowledge, these values represent the highest mid-IR power obtained through wavelength conversion of an eye-safe fiber source.
Future Potential of 2-Photon Fluorescence Microscopy in Mohs and General Dermatology Practice (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Geometric landscapes for material discovery within energy–structure–function maps (2020)

Porous molecular crystals are an emerging class of porous materials formed by crystallisation of molecules with weak intermolecular interactions, which distinguishes them from extended nanoporous materials like metal-organic frameworks (MOFs). To aid discovery of porous molecular crystals for desired applications, energy-structure-function (ESF) maps were developed that combine <i>a priori</i> prediction of both the crystal structure and its functional properties. However, it is a challenge to represent the high-dimensional structural and functional landscapes of an ESF map and to identify energetically favourable and functionally interesting polymorphs among the 1000s to 10 000s of structures typically on a single ESF map. Here, we introduce geometric landscapes, a representation for ESF maps based on geometric similarity, quantified by persistent homology. We show that this representation allows the exploration of complex ESF maps, automatically pinpointing interesting crystalline phases available to the molecule. Furthermore, we show that geometric landscapes can serve as an accountable descriptor for porous materials to predict their performance for gas adsorption applications. A machine learning model trained using this geometric similarity could reach a remarkable accuracy in predicting the materials' performance for methane storage applications.
Potato sucrose transporter expression in minor veins indicates a role in phloem loading. (1993)

The major transport form of assimilates in most plants is sucrose. Translocation from the mesophyll into the phloem for long-distance transport is assumed to be carrier mediated in many species. A sucrose transporter cDNA was isolated from potato by complementation of a yeast strain that is unable to grow on sucrose because of the absence of an endogenous sucrose uptake system and the lack of a secreted invertase. The deduced amino acid sequence of the potato sucrose transporter gene StSUT1 is highly hydrophobic and is 68% identical to the spinach sucrose transporter SoSUT1 (pS21). In yeast, the sensitivity of sucrose transport to protonophores and to an increase in pH is consistent with an active proton cotransport mechanism. Substrate specificity and inhibition by protein modifiers are similar to results obtained for sucrose transport into protoplasts and plasma membrane vesicles and for the spinach transporter, with the exception of a reduction in maltose affinity. RNA gel blot analysis shows that the StSUT1 gene is highly expressed in mature leaves, whereas stem and sink tissues, such as developing leaves, show only low expression. RNA in situ hybridization studies show that the transporter gene is expressed specifically in the phloem. Both the properties and the expression pattern are consistent with a function of the sucrose transporter protein in phloem loading.
Deformed symmetries from quantum relational observables (2007)

Deformed Special Relativity (DSR) is a candidate phenomenological theory to describe the Quantum Gravitational (QG) semi-classical regime. A possible interpretation of DSR can be derived from the notion of deformed reference frame. Observables in (quantum) General Relativity can be constructed from (quantum) reference frame – a physical observable is then a relation between a system of interest and the reference frame. We present a toy model and study an example of such quantum relational observables. We show how the intrinsic quantum nature of the reference frame naturally leads to a deformation of the symmetries, comforting DSR to be a good candidate to describe the QG semi-classical regime.
Stereoselective Synthesis of Pyroglutamate Natural Product Analogs from &#945;- Aminoacids and their Anti-Cancer Evaluation (2013)

Alkylation of α-amino acid derived iminoesters with Baylis-Hillman (BH) reaction template based allyl bromides/allyl acetates followed by acidic hydrolysis furnished α-methylene-β-substituted-pyroglutamates and α-alkylidene pyroglutamates respectively. Application of these methodologies has been demonstrated in the synthesis of fused [3.2.0]-γ-lactam-β-lactones. Further, substrate controlled stereoselective alkylation of L-threonine derived oxazoles with BH reaction based allyl bromides and acetates yielded optically pure α-methylene-β-substituted pyroglutamates, and α-alkylidene pyroglutamates. These methodologies have been applied in the preparation of chiral [3.2.0] heterobicyclic pyroglutamates containing hydroxyethyl side chain. All the synthesized pyroglutamates have been evaluated for their anti-cancer and enzyme proteasome inhibition activity.
[Progressive supranuclear palsy; an unusual form of parkinsonism]. (2004)

Progressive supranuclear palsy is a neurodegenerative disorder accompanied by parkinsonism, disturbances of eye movements, pseudobulbar palsy and often cognitive decline. Onset of disease is usually between 50-70 years of age and mean survival is 5-8 years. The prevalence of PSP has been estimated at around 5 per 100,000, although exact figures for the population of the Netherlands are not yet available. International consensus criteria differentiate between possible, probable and definite PSP; the latter requiring neuropathological confirmation. An extensive differential diagnosis may be made early in the course of the disease, but at a later stage development of the characteristic symptoms will make diagnosis easier. Imaging techniques can lend support to the clinical diagnosis to a limited extent, although they lack sufficient specificity to confirm it. PSP is a 'tauopathy' characterized by aggregates of abnormal tau protein in the basal ganglia and brainstem. Some mutations in the tau gene can cause a clinical and pathological picture similar to that of PSP, although most patients with sporadic and familial PSP do not have tau mutations. Various studies have found a strong association between PSP and a specific tau haplotype (H1 haplotype), but its role in the pathophysiological mechanism of PSP is still unclear and needs further research.
DOP83 Efficacy and Safety of Ustekinumab for Ulcerative Colitis Through 3 Years: UNIFI Long-term Extension (2021)

Abstract Background Ustekinumab (UST) is an IL-12/23p40 antagonist used to treat pts with moderate-to-severe ulcerative colitis (UC). The ongoing UNIFI long-term extension (LTE) evaluates subcutaneous (SC) 90mg UST maintenance therapy, with efficacy (wk152) and safety (wk156) results reported here. Methods 523 intravenous UST induction responders were randomized to SC maintenance therapy (175 SC placebo [PBO]; 172 UST 90mg every 12 weeks [q12w]; 176 UST 90mg q8w). 284 UST pts who completed wk44 entered the LTE. PBO pts were discontinued after wk44 unblinding. Starting at wk56, randomized pts with UC worsening could adjust to q8w. Symptomatic remission (Mayo stool frequency subscore of 0 or 1 and a rectal bleeding subscore of 0) was evaluated in randomized pts. Safety was evaluated for all 588 pts treated in the LTE, including the randomized and nonrandomized populations; 188 received PBO and 457 received UST. The nonrandomized population included responders to PBO induction and UST induction nonresponders at wk8 who received SC UST, responded 8 wks later and received UST 90mg q8w. Results Among all pts randomized to UST at maintenance baseline (intent-to-treat population with nonresponder imputation for missing data and treatment failure criteria), 55.2% were in symptomatic remission at wk152 (biologic naïve, 66.1%; biologic failures, 43.5%; Table 1); 96.4% (185/192) of pts in symptomatic remission at wk152 were corticosteroid-free. Overall, 20.1% (39/149 biologic failure, 16/149 biologic naïve) of pts who were randomized to UST and treated in the LTE discontinued treatment between wks44 and 156. Among randomized pts treated with UST in the LTE, 67.6% were in symptomatic remission at wk152; 76.4% of those in clinical remission at wk44 were in symptomatic remission at wk152; and 84.1% of pts with observed data at wk152 were in symptomatic remission. From maintenance wk0-156, combined UST and PBO pts had 1281.6 and 425.0 pt-years of follow-up, respectively; and safety events per 100 pt-years of follow-up for combined UST vs PBO were AEs: 235.81 vs 204.48, SAEs: 7.73 vs 7.53, and serious infections: 2.34 vs 2.35 (Table 2). From wks96-156, there were no reported deaths or major adverse cardiovascular events. One UST-treated pt with fair skin and a prior history of basal cell carcinoma (BCC) reported 2 BCC. One 90 mg q8w UST pt receiving concomitant 6-MP reported SAEs of neutropenic sepsis and oral herpes SAE; the latter events were considered potential opportunistic infections. The dose of 6-MP was reduced, pt recovered and continued UST. Conclusion The efficacy of UST in pts with UC was sustained through 3 years. No new safety signals were observed.
[ω‐(Phosphanyl)alkyl]cyclopentadienyl Complexes (1993)

Abstract The syntheses and characterisation of the [ω‐(phosphanyl)alkyl]cyclopentadienyl anions 2, 3, 6–8, 10 , and 11 are described. These anions form metallocenes 12–15 and 17–19 with FeCl 2 · 2 THF and with ZrCl 4 · 2 THF, respectively. With ICo(CO) 4 chelated carbonbyl complexes 23–25, 28 , and 29 are formed. The unchelated intermediate 20 has been detected by IR spectroscopy. The carbonyl chelate complexes are thermally stable. Under photochemical conditions, ligand exchange reactions are possible which in the case of 1,5‐cyclooctadiene proceed with decomplexation of the phosphane arm. This does not prevent a reaction at the cobalt(I) atom; treatment of 35 with diphenylethyne gives the corresponding tetraphenylcyclobutadiene complex 36 in good yield, the phosphane arm remaining uncoordinated.
Multicell cooperation: evolution of coordination and cooperation in large-scale networks (2013)

Due to the large growth of mobile communications over the past two decades, the supporting cellular systems have continuously needed to expand and evolve in order to meet the ever increasing demand of wireless connections. While simple frequency reuse and power control were enough to manage the demand of these networks at first, multicellular cooperation and coordination have become paramount to the operation of larger and more highly utilized communication systems. This article discusses the development of different techniques for cooperation in large cellular networks, and offers insights into the need for such an evolution. We investigate various branches of multicell cooperation, including user-based cooperation, system-wide optimization, and the opportunity of multiple-base-station transmission. Furthermore, we offer an example of a recently proposed technique designed for multicell cooperation in full frequency reuse orthogonal frequency-division multiple access networks.
Transaction reordering with application to synchronized scans (2008)

Traditional workload management methods mainly focus on the current system status while information about the interaction between queued and running transactions is largely ignored. An exception to this is the transaction reordering method, which reorders the transaction sequence submitted to the RDBMS and improves the transaction throughput by considering both the current system status and information about the interaction between queued and running transactions. The existing transaction reordering method only considers the reordering opportunities provided by analyzing the lock conflict information among multiple transactions. This significantly limits the applicability of the transaction reordering method. In this paper, we extend the existing transaction reordering method into a general transaction reordering framework that can incorporate various factors as the reordering criteria. We show that by analyzing the resource utilization information of transactions, the transaction reordering method can also improve the system throughput by increasing the resource sharing opportunities among multiple transactions. We provide a concrete example on synchronized scans and demonstrate the advantages of our method through experiments with a commercial parallel RDBMS.
Controllable dual protein delivery through electrospun fibrous scaffolds with different hydrophilicities (2013)

Tissue engineered scaffolds should actively participate not only in structural support but also in functional tissue regeneration. Thus, novel smart biomaterial scaffolds have been developed, which incorporate a variety of bioactive molecules to accelerate neo-tissue formation. The effective delivery of multiple bioactive molecules with distinct kinetics to target sites at an appropriate concentration and in a timely manner is desired to drive tissue development to completion. To achieve effective, controllable delivery of multiple factors, a dual protein delivery system has been developed by electrospinning poly(lactide-co-glycolide) (PLGA) with different hydrophilicities. Bovine serum albumin or myoglobin was incorporated into and released gradually from these electrospun fibrous PLGA scaffolds. All the scaffolds exhibited similar loading efficiencies of approximately 80% of the target proteins. The introduction of Pluronic F-127 (PF127) dramatically increased scaffold hydrophilicity, which affected the release kinetics of these proteins from the scaffolds. Furthermore, distinct protein release patterns were achieved when using dual protein-loaded scaffolds with different hydrophilicities when these scaffolds were fabricated by co-electrospinning. This system may be useful as a method for delivering multiple bioactive vehicles for tissue engineering applications.