gebhart/patrepeval huggingface dataset:
Fixture optimization for sheet panel assembly considering welding gun variations (2008)

Sheet panel assembly in automotive body manufacturing typically involves fixturing (including locating and clamping), joining (especially welding), and unclamping. Research has shown that the choices of fixturing schemes are important and that fixture optimization can generally improve the assembly dimensional quality with reduced assembly distortions. However, these research studies generally modelled weld guns as constant disturbances (such as deterministic forces) without considering the weld gun variations to avoid the complexity of Monte Carlo simulations. In the current paper, a fixture optimization model is formulated to minimize the assembly dimensional variations under welding gun variations. It is shown that, by using the proposed weld gun variations model, an assembly variation simulation can be converted to a deterministic assembly model, eliminating the need for Monte Carlo simulation. The efficiency improvement makes it feasible for a full scale optimization solution for optimal fixture locations with welding variations. The current paper further introduces the fixture-element models for continuous variable optimization in finite-element analysis, an enabler for fixture optimization. Numerical examples are shown to demonstrate the proposed methods.
Fabrication and characterization of a nanosensor for admittance spectroscopy of biomolecules (1995)

We have fabricated nanometer-sized interdigitated electrode patterns using electron beam lithography and liftoff techniques. The aim of the investigation was to find out whether the dimensions (i.e., the electrode separations) of the pattern would affect the admittance signal of the biomolecules in between the electrodes. Since the admittance signal scales with the geometrical factor A/d, where A is the electrode area and d is the separation, we chose to keep A/d constant when changing the electrode separation in order to eliminate this trivial effect on the admittance signal. An interdigitated electrode structure having an interelectrode spacing in the nanometer regime makes it possible to reach high nonstationary as well as stationary electric field strengths while having a low applied voltage level. Hence, electrode reactions will be as small as possible, while a high signal to noise ratio is obtained. We have been able to experimentally study the response of the impedance behavior to high electric fields exhibiting either a positive or a negative shift of the permittivity as a function of the field being a high alternating-current or a direct-current field, respectively.
Toward a Secure Internet of Things: Directions for Research (2020)

The current state of the Internet of Things (IoT) is woefully insecure, and reaching a secure state requires addressing several serious gaps. Based on discussions with practitioners and researchers, we identify key gaps and research challenges that must be overcome to chart a path toward a secure IoT.
Dapagliflozin in heart failure with preserved and mildly reduced ejection fraction: rationale and design of the DELIVER trial (2021)

DELIVER will determine the efficacy and safety of the SGLT2 inhibitor dapagliflozin, added to conventional therapy, in patients with heart failure and preserved and mildly reduced ejection fraction.
Bit error probability of differentially detected (G)MSK in unequalized mobile radio channels (2002)

We describe a new method for the analytical computation of the bit error probability BER of minimum shift keying (MSK) in indoor mobile radio channels. We include the following effects: (i) additive white Gaussian noise; (ii) time dispersion of the channel; (iii) Gaussian filtering of the data sequence (GMSK); (iv) receiver filtering. The channel is an N-path Rayleigh fading channel with arbitrary mean amplitudes of the paths and can also contain a line-of-sight component (i.e. Rician statistics). The sampling is done at a fixed but arbitrary instant. We first set up the general equations for occurrence of an error; direct evaluation of this equation requires the evaluation of a quadruple integral. We then develop closed-form approximate equations for the BER of unfiltered MSK that are valid for small BER. Finally, we develop a new mathematical formalism, which we call the two-path equivalent matrix (TPEM) method, which allows exact evaluation of the BER by solving a single well conditioned numerical integral; for small BERs we find closed-form expressions that are valid both for unfiltered and filtered (G)MSK. In order to prove the validity of our equations, we compare results to Monte-Carlo simulations and demonstrate excellent agreement.
Stretchable Silver Nanowire–Elastomer Composite Microelectrodes with Tailored Electrical Properties (2015)

We introduce a photolithography process compatible with soft and rigid substrates, enabling the fabrication of complex 3D interconnected patterns of silver nanowire (AgNW) networks embedded in polydimethylsiloxane (PDMS). Dimensions of the AgNW micropatterns are controlled within the film plane by photolithography, whereas thickness is controlled via a novel and uniform deposition technique using centrifugation. We report the first systematic characterization of the electromechanical properties of such microelectrodes with finest stretchable feature of 15 μm. We observe a geometry-dependent behavior of the gauge factor not only by changing the thickness of the microelectrodes, as it has been commonly reported so far, but also by varying their lateral dimensions. The presented nanocomposites exhibited sheet resistances down to 0.6 Ω/sq, gauge factors ranging from 0.01 to 100, and stretchability above 50% uniaxial strain. This versatile process allows for the production of highly sensitive strain sensors and robust high-density stretchable conductors on a wafer scale with direct implications in mass production of stretchable electronic devices.
Development of an Electrochemical Oxidation Method for Probing Higher Order Protein Structure with Mass Spectrometry (2008)

We report here the novel use of electrochemistry to generate covalent oxidative labels on intact proteins in both non-native and physiologically relevant solutions as a surface mapping probe of higher order protein structure. Two different working electrode types were tested across a range of experimental parameters including voltage, flow rate, and solution electrolyte composition to affect the extent of oxidation on intact proteins, as measured both on-line and off-line with mass spectrometry. Oxidized proteins were collected off-line for proteolytic digestion followed by LC-MS/MS analysis. Peptide MS/MS data were searched with the InsPecT scoring algorithm for 46 oxidative mass shifts previously reported in the literature. Preliminary data showed reasonable agreement between amino acid solvent accessibility and the resulting oxidation status of these residues in aqueous buffer, while more buried residues were found to be oxidized in non-native solution. Our results indicate that electrochemical oxidation using a boron-doped diamond electrode has the potential to become a useful and easily accessible tool for conducting oxidative surface mapping experiments.
Epstein-Barr virus infection precedes clonal expansion in Burkitt's and acquired immunodeficiency syndrome-associated lymphoma [see comments] (1991)

The Epstein-Barr virus (EBV) is associated with distinct forms of human lymphoid malignancies, including the endemic (eBL) and sporadic forms of Burkitt's lymphoma (sBL) and acquired immunodeficiency syndrome- associated non-Hodgkin lymphoma (AIDS-NHL). However, whether EBV has a pathogenetic role in these tumors or is a passenger virus has not been conclusively demonstrated. One element to distinguish between these two possibilities is to determine whether EBV infection has preceded and, thus, possibly contributed to clonal expansion, or whether infection has occurred after clonal expansion and thus is unlikely to contribute to pathogenesis. Toward this end we analyzed the structure of the heterogeneous genomic termini of EBV as markers of clonal infection in a panel of eBL (11 cases), sBL (9 cases), and AIDS-NHL (10 cases) biopsies. We show that EBV termini are uniformly clonal in sBL, eBL, and AIDS-NHL, strongly suggesting that EBV infection has preceded and, thus, most likely contributed to clonal expansion in these malignancies.
Noninvasive measurements of body composition and body water via quantitative magnetic resonance, deuterium water, and dual-energy x-ray absorptiometry in awake and sedated dogs (2013)

QMR was useful for determining body composition in dogs and can be used to safely and rapidly acquire accurate data without the need for sedation or anesthesia. These benefits can facilitate frequent scans, particularly in geriatric, extremely young, or ill pets. Compared with the D2O dilution method, QMR correction equations provided accurate assessment over a range of body compositions.
Recent results from Fermilab E791 (1995)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation A. Nguyen, E. M. Aitala, S. Amato, J. C. Anjos, J. A. Appel, M. Aryal, D. Ashery, S. Banerjee, I. Bediaga, G. Blaylock, S. B. Bracker, P. R. Burchat, R. A. Burnstein, T. Carter, H. S. Carvalho, I. Costa, L. M. Cremaldi, C. Darling, K. Denisenko, T. Dubbs, A. Fernandez, P. Gagnon, S. Gerson, K. Gounder, D. Granite, M. Halling, G. Herrera, G. Hurwitz, C. James, P. A. Kasper, S. Kwan, D. C. Langs, J. Leslie, J. Lichtenstadt, B. Lundberg, S. MayTal‐Beck, B. Meadows, J. R. T. de Mello Neto, R. H. Milburn, J. M. de Miranda, A. Napier, A. B. d’Oliveira, K. C. Peng, L. P. Perera, M. V. Purohit, B. Quinn, S. Radeztsky, A. Rafatian, N. W. Reay, J. J. Reidy, A. C. dos Reis, H. A. Rubin, A. K. S. Santha, A. F. S. Santoro, A. Schwartz, M. Sheaff, K. O’Shaughnessy, R. A. Sidwell, A. J. Slaughter, J. G. Smith, M. D. Sokoloff, N. Stanton, K. Sugano, D. J. Summers, S. Takach, K. Thorne, A. K. Tripathi, S. Watanabe, R. Weiss, J. Wiener, N. Witchey, E. Wolin, D. Yi, R. Zaliznyak, C. Zhang; Recent results from Fermilab E791. AIP Conf. Proc. 10 July 1995; 338 (1): 777–780. https://doi.org/10.1063/1.48447 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Ventricular fluid interleukin-1 activity in patients with head injury. (1987)

Patients with severe head injury are hypermetabolic and hypercatabolic, and manifest several components of the acute phase response. Interleukin-1 (IL-1) is a cytokine that mediates many aspects of the acute phase response, and rats with experimental head injury produce IL-1 of brain origin. IL-1 administered intracerebroventricularly to experimental animals has disproportionately greater systemic biologic effects compared with IL-1 injected intravenously. In this study, patients with severe head injury were evaluated to determine whether IL-1 activity in the ventricular fluid was increased and whether IL-1 levels correlated with some of the altered metabolic responses. Twelve hospitalized patients with head injury (24-hour peak admission Glasgow Coma Scale scores of 4 to 10) were evaluated on admission and longitudinally for 21 days after injury. IL-1 activity in ventricular fluid from patients with head injury was significantly elevated whereas IL-1 activity in cerebrospinal fluid from age- and sex-matched patients undergoing lumbar puncture for myelograms was not detectable (P less than 0.005). The patients with head injury had clinical and biochemical indicators of IL-1 activity such as fever, hypozincemia, and increased C-reactive protein levels that improved during the period of hospitalization. It is speculated that the elevated IL-1 activity may play a role in the altered metabolic response of patients with severe head injury.
Long-term Persistence of Anti-factor VIII Antibody-secreting Cells in Hemophilic Mice after Treatment with Human Factor VIII (2002)

The analysis of anti-factor VIII (FVIII) antibody-secreting cells (ASC) at different anatomic sites provides valuable information about the nature of the anti-FVIII immune response in hemophilic mice after treatment with human FVIII. An Elispot system is described that is suitable for analyzing frequencies and IgG subclasses of anti-FVIII ASC at the single-cell level. Hemophilic mice were treated with four doses of FVIII. Anti-FVIII antibodies in blood as well as anti-FVIII ASC in spleen and bone marrow were analyzed after each dose of FVIII and subsequently up to 22 weeks after termination of the FVIII treatment. Anti-FVIII ASC first appeared in the spleen where they were detectable after two intravenous doses of FVIII. Their appearance correlated with that of anti-FVIII antibodies in blood plasma. Anti-FVIII ASC in bone marrow were detectable after three doses of FVIII and were probably cells that initially formed in the spleen and subsequently migrated to the bone marrow. Whereas the frequency of anti-FVIII ASC in the spleen increased up to the fourth dose of FVIII and declined thereafter, in the bone marrow it remained constant for up to at least 22 weeks after the termination of the FVIII treatment. Titers of anti-FVIII antibodies in blood plasma increased up to the fourth dose of FVIII, then remained high constantly for 14 weeks and decreased but the antibodies were still detectable for up to at least 22 weeks after the fourth dose of FVIII. The IgG-subclass distribution of anti-FVIII ASC was similar in spleen and bone marrow and matched the subclasses of anti-FVIII antibodies in blood plasma indicating that both organs contribute to circulating antibodies in the blood.
A 106 Gb/s 2.5 Vppd Linear Microring Modulator Driver with Integrated Photocurrent Sensor in 28nm CMOS (2022)

A low-power CMOS linear driver IC, optimized for microring modulator-based co-packaged optics, is presented. This 2.5 V ppd driver, assembled with a photonic IC, achieves 2 dB TDECQ at 106 Gb/s PAM4 with 1.33 pJ/bit efficiency.
Optimal Delay-Outage Analysis for Noise-Limited Wireless Networks with\n Caching, Computing, and Communications -- Derivations and Proofs (2021)

Performance assessment and optimization for networks jointly performing\ncaching, computing, and communication (3C) has recently drawn significant\nattention because many emerging applications require 3C functionality. However,\nstudies in the literature mostly focus on the particular algorithms and setups\nof such networks, while their theoretical understanding and characterization\nhas been less explored. To fill this gap, this paper conducts the asymptotic\n(scaling-law) analysis for the delay-outage tradeoff of noise-limited wireless\nedge networks with joint 3C. In particular, assuming the user requests for\ndifferent tasks following a Zipf distribution, we derive the analytical\nexpression for the optimal caching policy. Based on this, we next derive the\nclosed-form expression for the optimum outage probability as a function of\ndelay and other network parameters for the case that the Zipf parameter is\nsmaller than 1. Then, for the case that the Zipf parameter is larger than 1, we\nderive the closed-form expressions for upper and lower bounds of the optimum\noutage probability. We provide insights and interpretations based on the\nderived expressions. Computer simulations validate our analytical results and\ninsights.\n
Reversible phase-change behavior in two-dimensional antimony telluride (Sb2Te3) nanosheets (2018)

Potential two-dimensional (2D) van der Waals crystals with mechanical flexibility, transparency, and low cost are viable material platforms for future nanodevices. Resistive switching behavior in 2D layered Sb2Te3 nanosheets is demonstrated. Nearly three orders of magnitude switch in sheet resistance were realized for more than 20 cycles. The observed hysteretic behavior is due to the change between crystalline and amorphous phases under a melt-quench-recrystallization mechanism. More importantly, the energy required to amorphize the nanosheets decreases exponentially with layer thickness reduction. It is expected that scaling to the ultimate two-dimensional limit in chalcogenide nanosheet-based phase change devices may meet or even exceed the energy efficiency of neurobiological architectures.
Abstract 4802: Cat eye syndrome chromosome region, candidate 1 (CECR1) is overexpressed and hypomethylated in salivary gland adenoid cystic carcinoma (2011)

Abstract BACKGROUND and PURPOSE: Salivary gland adenoid cystic carcinoma (ACC) is the second most common malignancy of the salivary glands. It is characterized by a heterogeneous morphology, perineural invasion, and a variable clinical course. The molecular mechanisms underlying ACC are still unknown. We previously developed a high-throughput integrative epigenomic screening method to discover novel proto-oncogene candidates in ACC. With this screening method, we found that cat eye syndrome chromosome region, candidate 1 (CECR1) was a promising oncogene candidate for ACC. CECR1 encodes a member of a subfamily of the adenosine deaminase protein family and acts as a growth factor through its adenosine deaminase activity. No previous studies have correlated CECR1 in human cancers. In the current study, we validated several features of CECR1 in primary ACC samples, including promoter methylation status and expression levels. METHODS and RESULTS: Bisulfite genomic sequencing was first employed to analyze the DNA methylation levels in the promoter of CECR1 in four ACC samples and four normal salivary gland tissues. Decreased methylation in CECR1 was found in three out of four ACC samples compared to zero out of four normal tissues. Secondly, quantitative methylation specific PCR (qMSP) was performed in a larger ACC cohort including 15 ACCs and 18 normal tissues. Consistent with the bisulfite genomic sequencing results, significant demethylation of CECR1 was detected in ACC samples (methylation levels ranged from 0.1 to 300.1; median, 19.8) compared to normal tissues (range from 10.2 to 600.0; median, 235.6), p &amp;lt; 0.05. Thirdly, we induced global demethylation in an ACC cell line, ACC83, by 5-aza-2′-deoxycytidine/ trichostatin A (5 Aza dC/TSA) treatment. Quantitative reverse transcription PCR (qRT-PCR) showed that CECR1 was significantly re-expressed in 5 Aza dC/TSA treated cell lines. Lastly, we analyzed the expression levels of CECR1 by qRT-PCR in the same ACC cohort. We found significant overexpression of CECR1 in ACCs compared to normal salivary tissue, p &amp;lt; 0.05. CONCLUSIONS: This is the first study to associate elevated CECR1 levels with salivary gland ACC. The transcription of CECR1 appears to be upregulated by promoter demethylation. Both overexpression and promoter hypomethylation of CECR1 are hallmarks of ACC. CECR1 might play an important role in salivary gland ACC. FUTURE DIRECTIONS: Functional studies of CECR1's role(s) in the carcinogenesis of salivary gland ACC are underway. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4802. doi:10.1158/1538-7445.AM2011-4802
AC Loss Simulation in HTS Armature Windings of A 100 kW All-HTS Motor (2021)

International audience
Using Dynamic Plasmonic Colors for Optical Cryptography (2019)

We experimentally demonstrate an all-aluminum metasurface that generates tunable plasmonic colors depending on the polarization states of the incident and reflected light. The metasurface produces high-resolution images and can be used to encrypt arbitrary information.
Harnessing Cooperative Interactions between Thermoresponsive Aptamers and Gels To Trap and Release Nanoparticles (2016)

We use computational modeling to design a device that can controllably trap and release particles in solution in response to variations in temperature. The system exploits the thermoresponsive properties of end-grafted fibers and the underlying gel substrate. The fibers mimic the temperature-dependent behavior of biological aptamers, which form a hairpin structure at low temperatures (T) and unfold at higher T, consequently losing their binding affinity. The gel substrate exhibits a lower critical solution temperature and thus, expands at low temperatures and contracts at higher T. By developing a new dissipative particle dynamics simulation, we examine the behavior of this hybrid system in a flowing fluid that contains buoyant nanoparticles. At low T, the expansion of the gel causes the hairpin-shaped fibers to extend into the path of the fluid-driven particle. Exhibiting a high binding affinity for these particles at low temperature, the fibers effectively trap and extract the particles from the surrounding solution. When the temperature is increased, the unfolding of the fiber and collapse of the supporting gel layer cause the particles to be released and transported away from the layer by the applied shear flow. Since the temperature-induced conformational changes of the fiber and polymer gel are reversible, the system can be used repeatedly to "catch and release" particles in solution. Our findings provide guidelines for creating fluidic devices that are effective at purifying contaminated solutions or trapping cells for biological assays.
Improvement of SiO<sub>2</sub>/4H-SiC Interface Quality by Post-Oxidation Annealing in N<sub>2</sub> at High-Temperatures (2016)

The efficient and practical method for SiO 2 /4H-SiC interface improvement using post-oxidation annealing (POA) in pure N 2 ambient was studied by means of x-ray photoelectron spectroscopy (XPS) analysis and electrical characterization. SiC-MOS capacitors with slope-shaped thermal oxides were used to investigate optimal conditions for interface nitridation. It was found that the amount of nitrogen atoms incorporated into the interfaces increased when raised the annealing temperature up to 1400°C, and thin oxide (&lt; 30 nm) was used. Furthermore, N 2 -POA at 1400°C was proven to be very promising as equivalent to NO-POA in terms of reduced interface state density of SiC-MOS devices.
Adaptive beam shaping with fiber array laser transceiver systems in power beaming applications (Conference Presentation) (2018)

In this paper we consider numerical model of an adaptive coherent fiber array system that is utilized for remote transmission of laser power to an active photovoltaic cell (PVC)-based receiver array. The PVC array performs optical-to-electrical power conversion, and provides a feedback signal that is sent to the laser transmitter via optical and/or RF link. The feedback signal is utilized for real-time adaptive shaping of laser power density distribution at the PVC array for achieving the following objectives: (a) Minimization of laser power losses caused by mismatch between size and shape of the transmitter beam footprint and the PVC array. For optimal performance, the projected laser beam footprint should be adaptively changed to fit the PVC area under continuously changing turbulence strength, distance to the target, system field of view, platform jitter, etc. and (b) Reduction of laser beam power fluctuations inside the PVC caused by errors in target/load tracking, and laser beam aimpointing and aimpoint stabilization. In the numerical simulations the optical power with adaptive beam shaping was performed over 3 km and 7 km distances in turbulent atmosphere. The results demonstrate ability of the adaptive fiber array systems with 21 sub-apertures considered, for efficient adaptive beam shaping resulting in significant power beaming efficiency improvement.