gebhart/patrepeval huggingface dataset:
Attitude and Enduring Involvement of Older Adults in Structured Programs of Physical Activity (1997)

The purpose of this paper is to measure the influence of the affective attitudinal domain upon the intentions of a group of older adults participating in structured programs of physical activity offered in a community recreation setting. The subjects were 118 seniors participating in either a fitness, aqua-fitness, or golf program in metropolitan Ottawa. The group comprised of 65 women and 53 men were, in the most part, between 55 and 70 years of age. A questionnaire measuring attitude towards physical activity was developed. A stepwise regression analysis of intention to participate on attitudes showed that most of the variance in intention (69.0%) was explained by the variable "good/beneficial," i.e., seniors perceived the programs as being good and beneficial to them. It is recommended that further investigation of affective factors related to attitude be carried out to develop strategies to maintain seniors involvement in physical activity programs.
Advances in interactive video scanning of paper documents (1999)

The paper describes the design and evaluation of CamWorks, a system that employs a video camera as a convenient means of capturing from paper sources during reading and writing. The user can view a live video image of the source document alongside the electronic document in preparation. We describe a novel user interface developed to support selection of text in the video window and several new techniques for segmentation, restoration and resolution enhancement of camera images. An evaluation shows substantially faster text capture than with flatbed scanning.
Large Electro-Optic Effect in Tensile Strained Ge-on-Si Films (2006)

We report the observation of an enhanced electro-optic effect in the weakly absorbing regime for tensile strained Ge epitaxial films. With Deltan/F=260 pm/V and Deltaalpha/alpha-3 the material has significant potential for field-induced phase or electro-absorption modulator devices
Clinical Isolates of Acinetobacter spp. Are Highly Serum Resistant Despite Efficient Recognition by the Complement System (2022)

Gram-negative bacteria from the genus <i>Acinetobacter</i> are responsible for life-threating hospital-related infections such as pneumonia, septicemia, and meningitis, especially in immunocompromised patients. Worryingly, <i>Acinetobacter</i> have become multi- and extensively drug resistant (MDR/XDR) over the last few decades. The complement system is the first line of defense against microbes, thus it is highly important to increase our understanding of evasion mechanisms used by <i>Acinetobacter</i> spp. Here, we studied clinical isolates of <i>Acinetobacter</i> spp. (n=50), aiming to characterize their recognition by the complement system. Most isolates tested survived 1 h incubation in 30% serum, and only 8 isolates had a lower survival rate, yet none of those isolates were fully killed. Intriguingly, four isolates survived in human whole blood containing all cell component. Their survival was, however, significantly reduced. Flow cytometry analyses revealed that most of the isolates were detected by human IgG and IgM. Interestingly, we could not detect any significant concentration of deposited C1q, despite observing C4b deposition that was abolished in C1q-deficient serum, indicating transient binding of C1q to bacteria. Moreover, several isolates were recognized by MBL, with C4b deposition abolished in MBL-deficient serum. C3b was deposited on most isolates, but this was not, however, seen with respect to C5b and formation of the membrane attack complex (MAC), indicating that many isolates could avoid complement-mediated lysis. India ink staining showed that isolates were capsulated, and capsule thickness varied significantly between isolates. Studies performed on a wild-type strain and capsule mutant strains, demonstrated that the production of a capsular polysaccharide is one mechanism that mediates resistance to complement-mediated bactericidal activity by preventing MAC deposition and lysis. Our data showed that most clinical <i>Acinetobacter</i> spp. isolates are highly serum resistant despite being efficiently recognized by the complement system.
Nicotinoyl Azide (NCA)‐Mediated Mitsunobu Reaction: An Expedient One‐Pot Transformation of Alcohols into Azides. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Glycogen Storage Disease Type III (Glycogen Debranching Enzyme Deficiency): Correlation of Biochemical Defects with Myopathy and Cardiomyopathy (1992)

Clinical features of glycogen storage disease type III correlate with the particular biochemical defect seen with the disorder. Assessments of debranching enzyme or debranching enzyme transferase activity in muscle can be used to predict whether patients with glycogen storage disease type III will develop myopathy and cardiomyopathy.
Phased-array vector velocity estimation using transverse oscillations (2012)

A method for estimating the 2-D vector velocity of blood using a phased-array transducer is presented. The approach is based on the transverse oscillation (TO) method. The purposes of this work are to expand the TO method to a phased-array geometry and to broaden the potential clinical applicability of the method. A phased-array transducer has a smaller footprint and a larger field of view than a linear array, and is therefore more suited for, e.g., cardiac imaging. The method relies on suitable TO fields, and a beamforming strategy employing diverging TO beams is proposed. The implementation of the TO method using a phased-array transducer for vector velocity estimation is evaluated through simulation and flow-rig measurements are acquired using an experimental scanner. The vast number of calculations needed to perform flow simulations makes the optimization of the TO fields a cumbersome process. Therefore, three performance metrics are proposed. They are calculated based on the complex TO spectrum of the combined TO fields. It is hypothesized that the performance metrics are related to the performance of the velocity estimates. The simulations show that the squared correlation values range from 0.79 to 0.92, indicating a correlation between the performance metrics of the TO spectrum and the velocity estimates. Because these performance metrics are much more readily computed, the TO fields can be optimized faster for improved velocity estimation of both simulations and measurements. For simulations of a parabolic flow at a depth of 10 cm, a relative (to the peak velocity) bias and standard deviation of 4% and 8%, respectively, are obtained. Overall, the simulations show that the TO method implemented on a phased-array transducer is robust with relative standard deviations around 10% in most cases. The flow-rig measurements show similar results. At a depth of 9.5 cm using 32 emissions per estimate, the relative standard deviation is 9% and the relative bias is -9%. At the center of the vessel, the velocity magnitude is estimated to be 0.25 ± 0.023 m/s, compared with an expected peak velocity magnitude of 0.25 m/s, and the beam-to-flow angle is calculated to be 89.3° ± 0.77°, compared with an expected angle value between 89° and 90°. For steering angles up to ±20° degrees, the relative standard deviation is less than 20%. The results also show that a 64-element transducer implementation is feasible, but with a poorer performance compared with a 128-element transducer. The simulation and experimental results demonstrate that the TO method is suitable for use in conjunction with a phased-array transducer, and that 2-D vector velocity estimation is possible down to a depth of 15 cm.
Potent Anticonvulsant 1H-Imidazol-5(4H)-One Derivatives with Low Neurotoxicity (2012)

We report here the synthesis and in vivo anticonvulsant/neurotoxicity activities of a series of compounds belonging to 2-aryl-4-arylidene-1-phenyl-1H-imidazol-5(4H)-one. The scaffold is based on the commonality of 5-membered lactam ring structures as successful anticonvulsant agents. The present compounds exhibited a range of anticonvulsant activity in pentylenetetrazole (PTZ)-induced seizure test. In particular, the protection was excellent by compounds bearing furylmethylidene on C4, possibly due to good pharmacokinetic properties. It was found that high lipophilicity and/or electron deficient aryl ring substitution at C4 compromised the anticonvulsant activities. For example, chloro analogues were found much less active than unsubstituted phenyl or furyl derivatives. Regarding side effects, active compounds exerted no observable neurotoxic effect at their therapeutic doses in Chimney test.
Real-Time Evaluation of Microwave Injection Locking Property for Resonant-Electrode-Type Optoelectronic Oscillator (2005)

In our former report, we have proposed a resonant-electrode-type optoelectronic oscillator (RE-OEO). An optical modulator used in the RE-OEO has a resonant electrode, over which standing wave arises around the frequency of the resonance. The frequency components out of the resonant frequency are highly suppressed, so that single-mode oscillation in microwave frequency is easily achieved. In addition, the RE-OEO oscillates with lower input threshold power since modulation efficiency can be improved at the resonant condition. We experimentally investigate, in this paper, the characteristics of injection locking for the RE-OEO when microwave near the oscillation frequency is launched on it.
A Linear Time and Space Algorithm for Optimal Traffic-Signal Duration at an Intersection (2014)

Finding an optimal solution for traffic-signal control duration is a computationally intensive task. It is typically O(T <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> ) in time and O(T <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) in space, where T is the length of the control interval in discrete-time steps. In this paper, we propose a linear time and space algorithm for the traffic-signal control problem. The algorithm provides an efficient dynamic programming formulation of the state space that prunes nonoptimal states early on. This paper proves the correctness of the algorithm and provides an initial experimental validation. This paper also conducts a simulation study comparing with other typical control methods. The results show significant improvement in the average waiting time metric with respect to all other methods.
BET Bromodomain Inhibitors Enhance Efficacy and Disrupt Resistance to AR Antagonists in the Treatment of Prostate Cancer (2016)

http://mcr.aacrjournals.org/content/molcanres/14/4/324/F1.large.jpg
EPTC 2021 Invited Technology Talk: Roadmap Based on Holistic Understanding of Thermo-Mechanical Challenges from Package to System to Maximize Silicon Performance (2021)

For several decades, microelectronic industries and relevant Academic communities have invested a tremendous effort in developing electronics to introduce many breakthroughs and revolutions in packaging technologies and repetitive efforts addressing traditional problems. In recent years, the push into the smaller Silicon node and having close proximity of different Silicon dies functionality is resulting in an ever-increasing awareness of R & D efforts and business drivers to speed up the product development. For the optimized performance of Silicon packages and addressing the impact of assembly, reliability the literature did not report the optimal configuration of the package in the light of clear technology roadmap to reflect the manufacturability and performance constraints. With heterogeneous integration of different Silicon dies with numerous of functionalities on a single package that lead to ever-increasing localization of the heat, a major challenge in forward-looking roadmaps includes the thermomechanical reliability of the Silicon package. With traditional and commercially available cooling solutions approaching their useful limit, the focus must be shifted towards improving the interfacial resistance namely TIMI, TIM2 by establishing better contact. The total system package from the active die to the heatsink includes several subsystems sequentially arranged. Each of the subsystem’s performance are high interactive or dependent on the other. This article emphasizes that the interaction of the die warpage with the elongation and adhesion of thermal interface materials (TIMs) plays a crucial role in determining the limits of Si packaging technologies. This can be seen clearly in a package size greater than 50mm x 50mm, which has a coplanarity of more than 8 mil. This type of package can have been MCM, Chiplets, CoWOs, EMIB or monolithic. Furthermore, this manuscript also forecasts the different cooling techniques of data centers to enable the future higher performance Silicon.
ChemInform Abstract: Catalytic Asymmetric Cyclocarbonylation of Nitrogen‐Containing Enynes. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Convenient Preparation of O‐Alkyl Selenoesters from Esters (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Discovery and Development of a Commercial Synthesis of Azafenidin (2001)

A commercial synthesis of the DuPont herbicide azafenidin is described. Discovery of a novel synthesis of the triazolinone ring system and a practical, environmentally benign process to 5-cyanovaleramide were critical breakthroughs in enabling azafenidin to be manufactured at an acceptable cost. The process began with the selective hydrolysis of DuPont's nylon intermediate, adiponitrile, to 5-cyanovaleramide. This was converted via Hofmann rearrangement and Pinner-type cyclization to afford the key amidine carboxylate intermediate containing both carbon atoms of the triazolinone ring. The preservation of all six carbon atoms of adiponitrile set up a 2 + 3 cyclocondensation with arylhydrazines, which replaced a costly 4 + 1 cyclocondensation of an amidrazone with phosgene or a phosgene surrogate used in the original route. This new triazolinone process was optimized to afford the commercial product in a highly efficient and economical fashion.
Forward Mapped Planar Mirror Reflections (1998)

: This paper presents a new technique, which we call depth-preserving reflection mapping, to render mirror-like reflections on planar surfaces in constant time. It is a hybrid solution which combines geometry-based rendering and imagebased rendering into a two-pass mirror reflection rendering approach. The technique extends the traditional reflection mapping to preserve depth per texel and uses forward warping to approximate the mirror-like reflections on planar surfaces. For clarity, to distinguish these texels from the ones of traditional reflection mapping, we call them zexels. 1 Introduction Architectural walkthrough applications enable the user to interact in real-time with computer-simulated environments [5]. An important goal is to represent the rich visual complexity of the scenes. Such complexity is usually achieved with realistic illumination and shading models to generate images of the scene. Unfortunately, interactive walkthrough applications trade photo-realism for frame ...
Visible, EPR and electron nuclear double‐resonance spectroscopic studies on the two metal‐binding sites of oxovanadium (IV)‐substituted D‐xylose isomerase (1991)

The two metal-binding sites of the D-xylose isomerase from Streptomyces rubiginosus were studied using VO2+ as a sensor for the ligand environment. Titration of the tetrameric enzyme with VO2+, followed by EPR spectroscopy and inhibition studies, show that the first four VO2+ equivalents occupy, in analogy to Co2+, Cd2+ and Pb2+, the binding site B. The visible absorption data and the EPR parameters indicate that a nitrogen ligand is involved in the ligand sphere of the high-affinity B site. The low-affinity A site could be studied selectively by blocking the B site with visible and EPR-silent Cd2+. The visible data and EPR parameters for this site are consistent with a ligand environment composed of oxygen donors without nitrogen ligation. The nitrogen coordination in the high-affinity site could be demonstrated by electron nuclear double-resonance (ENDOR) studies of the 4VO2+ enzyme, and was assigned to a histidine ligand. The 14N resonances are interpreted in terms of a quartet with a coupling value of 13.2 MHz. 1H-ENDOR coupling of 1.7 MHz, exchangeable in D2O, has been assigned to the N-H proton of the histidine. Additional proton ENDOR couplings, which are not exchangeable, are due to protons bound to the carbon atoms of the histidine. For the low-affinity binding site, a nitrogen coordination could be definitely excluded by the ENDOR measurements. Exchangeable 1H-ENDOR couplings observed in this sample were assigned to H2O ligands in the vicinity of VO2+. The results closely relate to what is known from X-ray structure. However, the relative affinities for the two binding sites seem not to be the same for different bivalent cations. In mixed metal samples with four VO2+ and four Co2+ equivalents, the VO2+ is distributed between both binding sites. Small changes in the complex geometry of the A site, indicated by different EPR features, seem to occur if the B site is occupied by Co2+ or by Cd2+.
SONOS memories with embedded silicon nanocrystals in nitride (2008)

We have successfully demonstrated SONOS memories with embedded Si-NCs in silicon nitride. This new structure exhibits excellent characteristics in terms of larger memory windows and longer retention time compared to control devices. Using the same thickness 2.5 nm of the bottom tunneling oxide, we found that N2O is better than O2 oxide. Retention property is improved when the thickness of N2O is increased to 3.0 nm.
Close the Gap – Potential of Microalgal Biomass for Closed ECLSS and Future In-Situ Resource Utilization in Space (2019)

Harald Helisch, Institute of Space Systems - University of Stuttgart, Germany
Microscale Spherical Carbon-Coated Li4Ti5O12 as High Power Anode Material for Lithium Batteries (2011)

Abstract not Available.
A Note on the Multiple Unicast Capacity of Directed Acyclic Networks (2011)

We consider the multiple unicast problem under network coding over directed acyclic networks with unit capacity edges. There is a set of n source-terminal (s <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> -t <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> ) pairs that wish to communicate at unit rate over this network. The connectivity between the s <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> -t <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> pairs is quantified by means of a connectivity level vector, [k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ... k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</sub> ] such that there exist k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> edge-disjoint paths between s <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> and t <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> . Our main aim is to characterize the feasibility of achieving this for different values of n and [k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> ... k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</sub> ]. For 3 unicast connections (n = 3), we characterize several achievable and unachievable values of the connectivity 3-tuple. In addition, in this work, we have found certain network topologies, and capacity characterizations that are useful in understanding the case of general n.
Mayo Clinic Electrophysiology Manual (2013)

Mayo Clinic Electrophysiology Manual is the first comprehensive guide to the electrical activity of biological cells and tissues and the techniques of electrophysiology. Through a case-based discussion of patients with arrhythmias, this resource illustrates the various contemporary techniques for diagnosis, imaging, and physiology-based therapeutic ablation.
Abstract A136: A systems approach to the preclinical evaluation of targeted chemoprevention for lung cancer (2008)

Abstract A136 The possibility of an “individualized medicine” approach to chemoprevention targeted to the specific molecular abnormalities in the individual at risk has been suggested as a means to tailor prevention strategies (Markowitz, N Engl J Med. 2007;356:2195-8). In order to initiate targeted chemoprevention for lung cancer, we have developed a pre-clinical system to assess potential chemoprevention agents against mutated human bronchial epithelial cell lines (HBEC). HBECs are exposed to drugs such as rosiglitazone, erlotinib and celecoxib and selected proliferative responses, gene expression, micro-RNA profiles and protein panels are assessed. This data is then assessed by systems analysis to determine the optimal chemopreventive agents against specific mutations. These data will ultimately be utilized both for agent selectivity and agent specific biomarker identification. In preliminary studies, we evaluated rosiglitazone, erlotinib and celecoxib against three genetically altered HBEC cell lines harboring mutations relevant in the pathogenesis of human lung cancer (p53 knockdown, K-rasV12 and EGFR L858R mutations). As a model of long-term tobacco exposure, NNK- treated HBEC cells are also being utilized. In addition to selected proliferation assays, we assessed each agent against HBEC cell lines and evaluated a 50 protein luminex profile as well as a panel of more than 700 micro RNAs. These potential chemopreventive agents reveal specific patterns of alterations in proliferation, gene expression, protein secretion and microRNA profiles. Based on these findings, assessment of combinations of preventive agents are in progress. We anticipate that these methods will assist in the development of agent specific biomarkers and a personalized approach to chemoprevention for lung cancer. This work is supported by the UCLA SPORE in Lung Cancer P50 90388, UT Southwestern SPORE in Lung Cancer P50CA75907 and The Flight Attendant Medical Research Institute (FAMRI) Young Clinical Scientist Awards. Citation Information: Cancer Prev Res 2008;1(7 Suppl):A136.