gebhart/patrepeval huggingface dataset:
Silicone‐based materials with tailored MR relaxation characteristics for use in reduced coil visibility and in tissue‐mimicking phantom design (2023)

Gd-based contrast agents can be effectively used to create Ecoflex silicone polymer-based phantoms with tailored T<sub>2</sub> relaxation properties. The relative low cost, ease of preparation, stretchability, mechanical stability, and long shelf life of Ecoflex silicone polymer all make it a good candidate for "MR invisible" coil development and bears promise for tissue-mimicking phantom development applicability.
Supplementary Figure 8 from TYK2–STAT1–BCL2 Pathway Dependence in T-cell Acute Lymphoblastic Leukemia (2023)

&lt;p&gt;PDF file - 105K, Signaling and cell cycle distribution after JAK inhibitor I treatment.&lt;/p&gt;
Gene Dosage–limiting Role of Aire in Thymic Expression, Clonal Deletion, and Organ-specific Autoimmunity (2004)

Inactivation of the autoimmune regulator (Aire) gene causes a rare recessive disorder, autoimmune polyendocrine syndrome 1 (APS1), but it is not known if Aire-dependent tolerance mechanisms are susceptible to the quantitative genetic changes thought to underlie more common autoimmune diseases. In mice with a targeted mutation, complete loss of Aire abolished expression of an insulin promoter transgene in thymic epithelium, but had no effect in pancreatic islets or the testes. Loss of one copy of Aire diminished thymic expression of the endogenous insulin gene and the transgene, resulting in a 300% increase in islet-reactive CD4 T cells escaping thymic deletion in T cell receptor transgenic mice, and dramatically increased progression to diabetes. Thymic deletion induced by antigen under control of the thyroglobulin promoter was abolished in Aire homozygotes and less efficient in heterozygotes, providing an explanation for thyroid autoimmunity in APS1. In contrast, Aire deficiency had no effect on thymic deletion to antigen controlled by a systemic H-2K promoter. The sensitivity of Aire-dependent thymic deletion to small reductions in function makes this pathway a prime candidate for more subtle autoimmune quantitative trait loci, and suggests that methods to increase Aire activity would be a potent strategy to lower the incidence of organ-specific autoimmunity.
Portal imaging and image analysis (2002)

Summary form only given. Electronic portal imaging performs verification of radiotherapy by taking patient images with the treatment beam which show the bony anatomy in relation to the treatment beam. For effective portal imaging, image acquisition equipment, reference images, image analysis software, and decision rules for minimizing setup errors are required. The past few years, the quantum efficiency of existing EPID systems has been improved, but the advent of solid-state flat panel imaging systems (almost all based on a scintillating screen coupled to an amorphous silicon light detector), is the most promising development. These devices take high quality images with acceptable dose. Quantitative analysis of portal images is a prerequisite for accurate decision making. The objectives of portal image analysis are: (1) verify that the treatment field has the right shape, (2) verify that the patient is in the correct position. As reference image a simulated radiograph from the CT data (for 2D analysis), or even the CT data itself (for 3D analysis). Finally, the measured deviations are fed into computerized decision protocols that reduce systematic (average) setup errors as much as possible with limited workload. User friendly implementation in commercial products, in particular of the image analysis software and decision rules, remains to be done.
Preparation of Spatially Modulated Porous Silicon Layers (2011)

This chapter contains sections titled: Time-Programmable Current Source Pore Modulation in the z-Direction: Double Layer Pore Modulation in the z-Direction: Rugate Filter More Complicated Photonic Devices: Bragg Stacks, Microcavities, and Multi-Line Spectral Filters Lateral Pore Gradients (in the x–y Plane) Patterning in the x–y Plane Using Physical or Virtual Masks Other Patterning Methods References
A 14 dBm 110–130 GHz power amplifier and doubler chain in 90 nm SiGe BiCMOS technology (2016)

A D-Band x2 frequency multiplier-amplifier chain implemented in an advanced 90 nm SiGe BiCMOS technology is presented. The chain achieves a peak output power of 14 dBm and consists of input balun and push-push frequency doubler which drives a single-ended three stages Power Amplifier (PA). It operates from 110 GHz to 130 GHz (3 dB power bandwidth) with 5 dBm input power at V-Band and consumes a total DC power of 200 mW from a 1.6 V supply. The stand-alone doubler achieves output power >5 dBm at 110–130 GHz and occupies area of only 0.15 mm2.
Effects of peptides on antioxidant status and survival curve parameters in inbred pre-selected lines in Drosophila melanogaster (2008)

We performed comparative genetic analysis of a set of synthetic peptides effects on longevity and free-radical oxidation in Drosophila melanogaster. Strong genotype and gene-environmental interaction in determining traits value were evaluated. Mechanisms of vilon and epithalon effect on free oxygen species in mitochondria seemed to be different.
Gait comparison of unicompartmental and total knee arthroplasties with healthy controls (2016)

UKA results in a more physiological gait compared with TKA, and a higher top walking speed. This difference in function was not detected by the OKS. Cite this article: Bone Joint J 2016;98-B(10 Suppl B):16-21.
Prognostic Fusion for Uncertainty Reduction (2007)

* Work was performed while the author was with GE Global Research Abstract — One of the most critical aspects of prognostics is uncertainty management. That is, the calculation and processing of uncertainty sources that will ultimately allow the assignment of a probability density function (PDF) around the estimate of remaining useful life. This is of prime importance because it will give the decision maker a handle on when to take action based on the current risk tolerance. Ideally, the PDF is narrow such that a risk cut-off is close to the estimate. Accounting for the different uncertainty sources and stacking them up is a key in the proper quantification of the spread of the estimate. This paper investigates how the fusion of two different estimators can aid in the uncertainty management process. The fusion method aggregates two prediction algorithm output PDFs. The fusion algorithm is based on a kernel-based regression through time that discounts events distant in time from the time currently being evaluated. First, raw prediction PDFs are scaled by the individual quality estimates (subjective quality estimates are used here). Next, the PDFs are combined using kernel regression and are then normalized. The resulting spread of the fused PDF is smaller than the original ones at the same level of risk. We present results that use data obtained from bearing rig test data. The results support the premise that prediction output fusion can lead to better performance.
Lactobacillus GG treatment during pregnancy for the prevention of eczema: a randomized controlled trial (2010)

Prenatal treatment with Lactobacillus rhamnosus GG was not sufficient for preventing eczema. If probiotics are effective for preventing eczema, then a postnatal component to treatment or possibly an alternative probiotic strain is necessary.
Synthesis and Biological Evaluation of Integrin Antagonists Containingtrans- andcis-2,5-Disubstituted THF Rings (2000)

The synthesis of a series of RGD mimetics is described. All compounds consist of a central 2,5-disubstituted tetrahydrofuran core, a variable linker to a guanidino group, and a beta-amino alanine unit to mimic the carboxylic acid. Three types of linkers were investigated: a simple four-atom methylene chain (type A, compounds 14, 15, 16, and 17), a four-atom methylene chain with an additional chiral center, and a nitrogen substituent (type B, compounds 38, 39, and 40), and an amide linker of different length with an additional chiral center (type C, compounds 59, 60, 61, and 62). A variety of compounds were tested as potential integrin antagonists in a receptor binding assay (alphaIIbbeta3, alphavbeta3, and alphavbeta5). The relative and absolute configuration of the chiral centers at the THF ring had a pronounced effect on the binding activity and selectivity. Compound 14 proved to be a selective inhibitor of alphaIIbbeta3 (IC50=20nM), whereas compound 40 exhibited high activity for binding of alphaIIbbeta3 (IC50=67nM) and alphavbeta3 (IC50=52nM).
DT-Diaphorase as a Bifunctional Enzyme Label That Allows Rapid Enzymatic Amplification and Electrochemical Redox Cycling (2017)

The most common enzyme labels in enzyme-linked immunosorbent assays are alkaline phosphatase and horseradish peroxidase, which, however, have some limitations for use in electrochemical immunosensors. This Article reports that the small and thermostable DT-diaphorase (DT-D) and electrochemically inactive 4-nitroso-1-naphthol (4-NO-1-N) can be used as a bifunctional enzyme label and a rapidly reacting substrate, respectively, for electrochemical immunosensors. This enzyme-substrate combination allows high signal amplification via rapid enzymatic amplification and electrochemical redox cycling. DT-D can convert an electrochemically inactive nitroso or nitro compound into an electrochemically active amine compound, which can then be involved in electrochemical-chemical (EC) and electrochemical-enzymatic (EN) redox cycling. Six nitroso and nitro compounds are tested in terms of signal-to-background ratio. Among them, 4-NO-1-N exhibits the highest signal-to-background ratio. The electrochemical immunosensor using DT-D and 4-NO-1-N detects parathyroid hormone (PTH) in phosphate-buffered saline containing bovine serum albumin over a wide range of concentrations with a low detection limit of 2 pg/mL. When the PTH concentration in clinical serum samples is measured using the developed immunosensor, the calculated concentrations are in good agreement with the concentrations obtained using a commercial instrument. Thus, the use of DT-D as an enzyme label is highly promising for sensitive electrochemical detection and point-of-care testing.
Horning‐Crown Macrocycles: Novel Hybrids of Calixarenes and Crown Ethers. (2004)

Novel macrocycles possessing ether linkages and 2,6-disubstituted phenolics were produced in one step and with 100% atom economy by\nisoaromatization of chameleon macrocyclic precursors possessing 2,6-diarylidenecyclohexanone moieties. Intramolecular hydrogen bonding\nof the phenolic hydrogen atoms influenced the shape of the macrocycles and dictated host−guest behavior.
A titanium vinylidene route to substituted allenes (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA titanium vinylidene route to substituted allenesStephen L. Buchwald and Robert H. GrubbsCite this: J. Am. Chem. Soc. 1983, 105, 16, 5490–5491Publication Date (Print):August 1, 1983Publication History Published online1 May 2002Published inissue 1 August 1983https://pubs.acs.org/doi/10.1021/ja00354a057https://doi.org/10.1021/ja00354a057research-articleACS PublicationsRequest reuse permissionsArticle Views662Altmetric-Citations96LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
First peptide/protein PEGylation with functional polymers designed by nitroxide-mediated polymerization (2011)

Well-defined fluorescent, α-functional polymethacrylates with PEG side chains were readily designed by nitroxide-mediated polymerization (NMP) from N-hydroxysuccinimidyl (NHS) ester-containing alkoxyamines based on the nitroxide SG1. These polymers were obtained without any purification beyond a simple precipitation. They exhibited tunable reactivities towards nucleophiles depending on the nature of the alkoxyamine used. Copolymers derived from the commercially available SG1-based alkoxyamine led to quantitative coupling with small molecules and a neuroprotective peptide whereas partial conjugation was obtained with lysozyme, used here as a model protein. Complete conjugation to the latter was obtained from similar copolymers exhibiting a less sterically hindered NHS extremity, via appropriate alkoxyamine structure, which represents the very first example of peptide/protein PEGylation with functional polymers derived from NMP.
Clock jitter in class-D audio power amplifiers (2007)

Many class-D audio amplifiers use a reference clock to fix the PWM carrier frequency. The jitter of the reference clock can cause significant voltage noise at the amplifier output. In this paper a simple model is presented that allows accurate prediction of the noise contribution from an integrated regenerative sawtooth oscillator to the output noise of a class-D audio amplifier. The implementation of an oscillator in a class-D amplifier is presented and the model is verified with measurements.
Imputing abundances and inferring direction of associations between histone modifications using neural processes (2022)

Abstract Histone post-translational modifications (HPTMs) play a vital role in the regulation of numerous cellular processes. However, systems level understanding of how HPTMs coordinate and interact with each other, and the direction of interactions remain unexplored due to lack of suitable technology. EpiTOF, a high-dimensional mass cytometrybased platform, measures HPTMs and histone variants across multiple immune cell sub-types at a single-cell resolution to enable the system-wide study of HPTMs. Large number of immune cells profiled using EpiTOF present an unprecedented opportunity to learn directional networks of HPTM associations. We developed a two-step computational framework to identify direction of association between two HPTMs. In the first step, we used linear regression (LR)-, k -nearest neighbors-( k NN), or Neural Processes (NP)-based to impute the abundance of HPTMs. In the second step, we developed an interpretation framework to infer direction of association between HPTMs at a system-level using mass cytometry data. We evaluated this framework using EpiTOF profiles of more than 55 million peripheral mononuclear blood cells from 158 healthy human subjects. NP models had consistently higher imputation accuracy than LR and kNN. The inferred networks recapitulated known HPTM associations and identified several novel ones. While almost all associations were conserved across all healthy individuals, in a cohort of healthy subjects, vaccinated with the trivalent inactivated seasonal influenza vaccine (TIV), we identified changes in associations between 6 pairs of HPTMs 30 days following vaccination, many of which have been shown to be functionally involved in innate memory. These results demonstrate utility of our framework in identifying causal interactions between HPTMs that can be further tested experimentally.
Near-Field Photochemical Imaging of Noble Metal Nanostructures (2005)

The sub-diffraction imaging of the optical near-field in nanostructures, based on a photochemical technique, is reported. A photosensitive azobenzene-dye polymer is spin coated onto lithographic structures and is subsequently irradiated with laser light. Photoinduced mass transport creates topographic modifications at the polymer film surface that are then measured with atomic force microscopy (AFM). The AFM images correlate with rigorous theoretical calculations of the near-field intensities for a range of different nanostructures and illumination polarizations. This approach is a first step toward additional methods for resolving confined optical near fields, which can augment scanning probe methodologies for high spatial resolution of optical near fields.
Digital and mixed-signal integrated circuits for an RFID telemetry system (2007)

Digital and mixed-signal circuits have been developed for use in an inductively-coupled RFID telemetry system that can interface with a sensor. The cells developed include a turn-on/brown-out detector, clock recovery circuit, a cyclic-redundancy code (CRC) generator, and a frequency-shift keying (FSK) modulator. These cells were designed for use in an RFID tag that also uses a novel approach to performing analog-to-digital conversion. The circuits were fabricated using the AMI 1.5 um CMOS process and tested using LabVIEWtrade. A key feature of these cells is their low current consumption of only 1-2 uA for the CRC generator and 5 uA for the clock recovery circuit.
Outcomes of Active Surveillance for Clinically Localized Prostate Cancer in the Prospective, Multi-Institutional Canary PASS Cohort (2015)

Most men remain on active surveillance at 5 years without adverse reclassification or adverse pathology at surgery. However, clinical factors had only a modest association with disease reclassification, supporting the need for approaches that improve the prediction of this outcome.
A Rabies-Specific Human Monoclonal Antibody That Protects Mice Against Lethal Rabies (1991)

According to a recommendation from WHO (World Health Organisation) for prevention of a possible rabies infection, active vaccination has to be combined with application of immunoglobulin to get a fast protective effect. At present, preparations of purified human or equine rabies-specific immunoglobulin are used. We have generated a human rabies-specific monoclonal antibody (huMAb) by immortalization of human B-cells with Epstein Barr Virus (EBV), followed by fusion with a mouse myeloma cell. The resulting clone TW-1 secrets an IgG1 lambda huMAb which specifically reacts in ELISA with 5 laboratory rabies virus strains of serotype 1 and DUV3 (Duvenhage, serotype 4). Western Blot analysis revealed fine specificity for the G glycoprotein (gp67) of rabies virus. HuMAb TW-1 neutralizes rabies virus in vitro (RFFIT) as well as in vivo and protects rabies infected mice. Compared to polyclonal human rabies immunoglobulins, huMAb TW-1 is advantageous, because of its defined specificity and the very low amounts of total protein needed for therapeutic effects.
Computationally Efficient Millimeter-Wave Scattering Models: A Multiple-Scattering Model (2022)

Backscattering by objects is a relevant phenomenon in millimeter-wave (mm-wave) propagation. Accordingly, computationally efficient models characterizing this process are now available in the literature. However, these models are restricted to single-surface contributions. In this article, we propose a multiple-scattering model for calculating backscattered fields due to consecutive interactions with several smooth electrically-large rectangular surfaces. The model is fundamentally based on the cascading of single-scattering events. In addition, the model is later extended to capture single-scattering blockage between backscattering events. The model is implemented using a Fresnel-integral-based method and validated by means of electromagnetic (EM) simulations and measurements. Furthermore, insight on the effects of the model parameters—number of surfaces, frequency, surface size, surface height-to-width ratio, surface displacement, and antenna-to-surface and surface-to-surface distances—is provided. Due to its computational efficiency, the proposed model can be suitable for system- and link-level simulations of wireless systems, particularly when Monte Carlo simulations are applied.
Mutual influence of parametric and Raman effects in silica fibers (1990)

Usually the parametric and the stimulated Raman scattering (SRS) effects in fibers are discussed independent of each other. We show here theoretically and experimentally that parametric interaction can suppress SRS in single-mode fibers. We also show that the Raman nonlinearity considerably changes the values of increment and frequency of modulational instability (MI).
Temperature Stability of Protein Monolayers Studied by Ellipsometry in the Infrared, Visible and Ultraviolet Spectral Regions (2006)

Temperature Stability of Protein Monolayers Studied by Ellipsometry in the Infrared, Visible and Ultraviolet Spectral Regions
Effects of Flow Field and Diffusion Layer Properties on Water Accumulation in a PEM Fuel Cell (2007)

Water is the main product of the electrochemical reaction in a proton exchange membrane (PEM) fuel cell. Where the water is produced over the active area of the cell, and how it accumulates within the flow fields and gas diffusion layers, strongly affects the performance of the device and influences operational considerations such as freeze and durability. In this work, the neutron radiography method was used to obtain two-dimensional distributions of liquid water in operating 50 cm2 fuel cells. Variations were made of flow field channel and diffusion media properties, to assess the effects on the overall volume and spatial distribution of accumulated water. Flow field channels with hydrophobic coating retain more water, but the distribution of a greater number of smaller slugs in the channel area improves fuel cell performance at high current density. Channels with triangular geometry retain less water than rectangular channels of the same cross-sectional area, and the water is mostly trapped in the two corners adjacent to the diffusion media. Also, it was found that cells constructed using diffusion media with lower in-plane gas permeability tended to retain less water. In some cases, large differences in fuel cell performance were observed with very small changes in accumulated water volume, suggesting that flooding within the electrode layer or at the electrode-diffusion media interface is the primary cause of the significant mass transport voltage loss.
Temperature behavior of AlGaN/GaN on SiC HEMTs (2005)

This study presents extensive characterization and comparison of current GaN/SiC devices (from 5 US manufacturers) across temperature (-25-125/spl deg/C). The changes with temperature for: saturated current (I/sub dss/), transconductance (g/sub m/), and maximum stable gain (MSG) are measured and statistics are studied. The typical temperature-coefficients (TC) are established for I/sub dss/, g/sub m/, and MSG in GaN technology. This information is useful for MMIC designs. The minimum temperature coefficients compare well with theoretical expectations. Finally, a correlation is observed between the temperature behavior of RF and DC parameters.