gebhart/patrepeval huggingface dataset:
Dielectric constant dispersion of yttrium-doped (Ba,Sr)TiO3 films in the high-frequency (10kHz–67GHz) domain (2005)

The frequency dispersion of the dielectric constant of yttrium (Y)-doped (Ba,Sr)TiO3 thin films (Y-BST) in the high-frequency domain (10kHz–67GHz) was investigated. In order to remove the substantial parasitic capacitances, inductances, and resistances from the measured impedance data, test samples, short-circuit standard, and open-circuit standard structures were fabricated and their frequency response was measured. Before removing parasitic components, the measured dielectric response showed a rolloff at approximately 4GHz. However, after circuit calibration, the dielectric constant was almost constant up to 40GHz where another rolloff was observed. However, this rolloff was due to the uncompensated small parasitic components. Therefore, the dielectric constant of the Y-BST films (170 with a film thickness of 30nm) showed small frequency dispersion corresponding to the Curie–von Schweidler dispersion, of which the exponent is −0.0131, up to 40GHz. Furthermore, the decrease of the capacitance was 17% in the frequency range from 10kHzto40GHz.
Profound remission in Crohn’s disease requiring no further treatment for 3–23 years: a case series (2020)

Prolonged remission has been achieved for 3-23 years with individualised treatments, with the majority using AMAT ± infliximab and FMT. Treatment with antibiotics and/or FMT provides a potential new avenue for treatment of CD. These findings should stimulate thinking, investigations and better therapy against MAP and the dysbiosis of the gut flora, to enable higher rates of prolonged remission.
Electrophoretic Nuclear Magnetic Resonance (ENMR)A New Tool for Studying Counterion Binding in Mixed Surfactant Systems (2003)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTElectrophoretic Nuclear Magnetic Resonance (ENMR)A New Tool for Studying Counterion Binding in Mixed Surfactant SystemsPeter C. Griffiths, Alison Paul, Peter Stilbs, and Erik PetterssonView Author Information Department of Chemistry, Cardiff University, P.O. Box 912, Cardiff CF10 3TB, U.K., and Department of Physical Chemistry, Royal Institute of Technology, Stockholm, Sweden S-100 44 Cite this: Langmuir 2003, 19, 20, 8605–8607Publication Date (Web):August 16, 2003Publication History Received9 May 2003Revised15 July 2003Published online16 August 2003Published inissue 1 September 2003https://pubs.acs.org/doi/10.1021/la034793phttps://doi.org/10.1021/la034793pbrief-reportACS PublicationsCopyright © 2003 American Chemical SocietyRequest reuse permissionsArticle Views199Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Counterions,Electrophoresis,Micelles,Sodium dodecyl sulfate,Surfactants Get e-Alerts
Experimental Study of Crude Oil Emulsion Stability by Surfactant and Nanoparticles (2018)

Abstract Surfactants and nanoparticles are materials being widely used for enhanced oil recovery (EOR). Surfactants are mainly used to reduce the interfacial tension between oil and water which could form a stable film of emulsion between these two immiscible fluids. Also, nanotechnology is a potential candidate to offer another solution to improve oil recovery. Nanoparticles can form a solid layer at the droplet's interface and stand as resistant stabilizer under harsh reservoir conditions. This research investigates whether the combination of surfactants and nanoparticles can form a stable emulsion than surfactants only. Two parts of experimental study have been done in this research. First part was implemented using three types of surfactant: nonionic surfactant with no charge group on its head, an anionic type carrying negative charge, and, cationic surfactant carries positive charge on the hydrophilic portion of the molecules in water. Second part was conducted using combinations of same surfactants mentioned above with nanoparticles. These nanoparticles are aluminum oxide (Al2O3) and silicon dioxide (SiO2). These two parts of experimental work were done using different ratios of water to oil from 1-9. Results showed that nonionic surfactant through water continuous phase could reach stability with heavy oils up to 40°C reservoir temperature while cationic surfactant through oil continuous phase could form stability reaching more than 60°C reservoir temperature. Meanwhile, anionic type could break the emulsion within a few hours. More emulsion stability could be achieved by adding Al2O3 and SiO2 nanoparticles to nonionic. Adding Al2O3 and SiO2 nanoparticles to anionic and cationic could form emulsion stability based on different water to oil ratio.
Structures of DNA-Linked Nanoparticle Aggregates (2006)

The room-temperature structure of DNA-linked gold nanoparticle aggregates is investigated using a combination of experiment and theory. The experiments involve extinction spectroscopy measurements and dynamic light scattering measurements of aggregates made using 60 and 80 nm gold particles and 30 base-pair DNA. The theoretical studies use calculated spectra for models of the aggregate structures to determine which structure matches the observations. These models include diffusion-limited cluster-cluster aggregation (DLCA), reaction-limited cluster-cluster aggregation (RLCA), and compact (nonfractal) cluster aggregation. The diameter of the nanoparticles used in the experiments is larger than has been considered previously, and this provides greater sensitivity of spectra to aggregate structure. We show that the best match between experiment and theory occurs for the RLCA fractal structures. This indicates that DNA hybridization takes place under irreversible conditions in the room-temperature aggregation. Some possible structural variations which might influence the result are considered, including the edge-to-edge distance between nanoparticles, variation in the diameter of the nanoparticles, underlying lattice structures of on-lattice compact clusters, and positional disorders in the lattice structures. We find that these variations do not change the conclusion that the room-temperature structure of the aggregates is fractal. We also examine the variation in extinction at 260 nm as temperature is increased, showing that the decrease in extinction at temperatures below the melting temperature is related to a morphological change from fractal toward compact structures.
Deleting Files in the Celeste Peer-to-Peer Storage System (2006)

Celeste is a robust peer-to-peer object store built on top of a distributed hash table (DHT). Celeste is a working system, developed by Sun Microsystems Laboratories. During the development of Celeste, we faced the challenge of complete object deletion, and moreover, of deleting "files" composed of several different objects. This important problem is not solved by merely deleting meta-data, as there are scenarios in which all file contents must be deleted, e.g., due to a court order. Complete file deletion in a realistic peer-to-peer storage system has not been previously dealt with due to the intricacy of the problem - the system may experience high churn rates, nodes may crash or have intermittent connectivity, and the overlay network may become partitioned at times. We present an algorithm that eventually deletes all file content, data and meta-data, in the aforementioned complex scenarios. The algorithm is fully functional and has been successfully integrated into Celeste
Speech2Face: Learning the Face Behind a Voice (2019)

How much can we infer about a person’s looks from the way they speak? In this paper, we study the task of reconstructing a facial image of a person from a short audio recording of that person speaking. We design and train a deep neural network to perform this task using millions of natural Internet/Youtube videos of people speaking. During training, our model learns voice-face correlations that allow it to produce images that capture various physical attributes of the speakers such as age, gender and ethnicity. This is done in a self-supervised manner, by utilizing the natural co-occurrence of faces and speech in Internet videos, without the need to model attributes explicitly. We evaluate and numerically quantify how–-and in what manner–-our Speech2Face reconstructions, obtained directly from audio, resemble the true face images of the speakers.
A role for major histocompatibility complex (MHC) class II molecules in MHC class I presentation and CD8 T cell priming (2008)

The CD4 T cell response against hen egg lysozyme (HEL) in non‐obese diabetic (NOD) mice comprises a majority of T cells reactive against HEL 11–25 despite the presence of another epitope, HEL 20–35, that binds to A g7 with comparable affinity. To investigate further the relationship between peptide affinity and the T cell response, we used ELISPOT to measure cytokine production after priming with HEL. As expected, HEL immunization of NOD mice generated HEL 11–25‐reactive CD4 T cells that secreted interleukin‐2 (IL2) and interferon‐γ (IFNγ). Surprisingly, HEL immunization also gave rise to a robust CD8 T cell response specific for HEL 23–31 presented by D b . Another interesting aspect of these studies was the finding that mice expressing D b but lacking A g7 showed a reduced or absent CD8 T cell response after HEL immunization. A lack of CD4 T cell help could not explain this result, as depletion of CD4 T cells prior to immunization with HEL had a minimal effect on CD8 T cell priming. To test the global effect of MHC class II molecules on MHC class I peptide selection, we have initiated mass spectrometry studies on peptides bound to K d in the presence or absence of A g7 . Initial results indicate a substantial difference in the K d peptide repertoire between cell lines with and without A g7 expression. Altogether, these data suggest a cooperativity between MHC class I and II that affects T cell priming and peptide selection.
Magic Number Pt13 and Misshapen Pt12 Clusters: Which One is the Better Catalyst? (2013)

A relationship between the size of metal particles and their catalytic activity has been established over a nanometer scale (2-10 nm). However, application on a subnanometer scale (0.5-2 nm) is difficult, a possible reason being that the activity no longer relies on the size but rather the geometric structure as a cluster (or superatomic) compound. We now report that the catalytic activity for the oxygen reduction reaction (ORR) significantly increased when only one atom was removed from a magic number cluster composed of 13-platinum atoms (Pt13). The synthesis with an atomic-level precision was successfully achieved by using a dendrimer ligand as the macromolecular template strictly defining the number of metal atoms. It was quite surprising that the Pt12 cluster exhibited more than 2-fold catalytic activity compared with that of the Pt13 cluster. ESI-TOF-mass and EXAFS analyses provided information about the structures. These analyses suggested that the Pt12 has a deformed coordination, while the Pt13 has a well-known icosahedral atomic coordination as part of the stable cluster series. Theoretical analyses based on density functional theory (DFT) also supported this idea. The present results suggest potential activity of the metastable clusters although they have been "missing" species in conventional statistical synthesis.
ChemInform Abstract: Synthesis of (.+‐.)‐3‐O‐Alkylated myo‐Inositol 1,4,5‐Trisphosphate Analogues as Potent Receptor Ligands and Enzyme Inhibitors. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Isolation of virulence genes directing surface glycosyl-phosphatidylinositol synthesis by functional complementation of Leishmania. (1993)

Trypanosomatid parasites of the genus Leishmania cause a spectrum of widespread tropical diseases. In the vertebrate host they reside within the macrophage phagolysosome; however, the mechanisms employed in this remarkable survival strategy are not well understood. Recent advances in the molecular genetics of these parasites prompted us to develop methods of functional genetic complementation in Leishmania and apply them to the isolation of genes involved in the biosynthesis of the virulence determinant lipophosphoglycan, an abundant glycosyl-phosphatidylinositol-anchored polysaccharide. LPG1, the gene product identified by complementation of the R2D2 mutant, appears to be a glycosyltransferase responsible for the addition of galactofuranosyl residues to the nascent lipophosphoglycan chain. As galactofuranose is not found in mammalian cells, inhibition of the addition of this sugar could be exploited for chemotherapy. Overall, the success of the functional complementation approach opens the way to the identification of a variety of genes involved in pathogenesis and parasitism.
A finite state control model for flexible robotized assembly cell (1992)

info:eu-repo/semantics/published
N-Alkoxyimidazolylidene Transition-Metal Complexes:  Application to [5+2] and [4+2] Cycloaddition Reactions (2007)

Silver(I) bis[(benzyloxy)imidazol-2-ylidene] complex 6 is prepared by reaction of an alkoxyimidazolium bromide (4) with Ag2O. In situ deprotonation of the alkoxyimidazolium bromide 4 afforded the rhodium(I) and palladium(II) complexes 7 and 8, whose structures were verified by X-ray crystallography. Rhodium(I) (benzyloxy)imidazolylidene complex 7 efficiently catalyzes the [5+2] cycloaddition reaction of an yne−vinylcyclopropane (93%) and the [4+2] cycloaddition reaction of a diene−yne (99%) at room temperature in minutes.
Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33 (2012)

House dust mite (HDM) is one of the most common allergens worldwide. In this study, we have addressed the involvement of IL-1 in the interaction between HDM and the innate immune response driven by lung epithelial cells (ECs) and dendritic cells (DCs) that leads to asthma. Mice lacking IL-1R on radioresistant cells, but not hematopoietic cells, failed to mount a Th2 immune response and did not develop asthma to HDM. Experiments performed in vivo and in isolated air-liquid interface cultures of bronchial ECs showed that TLR4 signals induced the release of IL-1α, which then acted in an autocrine manner to trigger the release of DC-attracting chemokines, GM-CSF, and IL-33. Consequently, allergic sensitization to HDM was abolished in vivo when IL-1α, GM-CSF, or IL-33 was neutralized. Thymic stromal lymphopoietin (TSLP) became important only when high doses of allergen were administered. These findings put IL-1α upstream in the cytokine cascade leading to epithelial and DC activation in response to inhaled HDM allergen.
Epidermal Growth Factor Receptor Activation in Glioblastoma through Novel Missense Mutations in the Extracellular Domain (2006)

Our results suggest extracellular missense mutations as a novel mechanism for oncogenic EGFR activation and may help identify patients who can benefit from EGFR kinase inhibitors for treatment of glioblastoma.
Heterogeneous Enantioselective Hydrogenation of Ketones by 2-Amino-2′-hydroxy-1,1′-binaphthyl-Modified CeO2-Supported Ir Nanoclusters (2021)

Modification of supported noble metals with chiral modifiers is a promising strategy for the design of effective heterogeneous chiral catalysts. The chiral compounds are generally introduced on the surface of noble metals, often leading to low enantioselectivity and to low activity. Herein, a unique heterogeneous chiral catalyst where a chiral modifier is introduced at the interface between the metal cluster and the support is presented. Modification of CeO2-supported Ir nanoclusters with 2-amino-2′-hydroxy-1,1′-binaphthyl (NOBIN) as a chiral modifier provided a heterogeneous chiral catalyst where NOBIN is introduced at the interface between Ir nanoclusters and the CeO2 support. The heterogeneous chiral catalyst enabled the asymmetric hydrogenation of acetophenone to provide 1-phenylethanol with moderate enantiomeric excess (ee) (up to 53%). The catalyst characterizations showed that about 1 nm Ir metal nanoclusters are formed on CeO2, and density functional theory calculations presented that NOBIN is adsorbed onto Ir nanoclusters and CeO2 at the NH2 and OH groups, respectively, constructing the asymmetric reaction field among NOBIN, Ir nanoclusters, and CeO2.
Association of autologous AdHER2 dendritic cell vaccination with antitumor activity and number of circulating tumor cells. (2017)

3089 Background: We achieved cure of large established tumors in syngeneic BALB/c mice using an adenoviral vector vaccine expressing rodent HER2 extracellular (EC) and transmembrane (TM) domains mediated by the induction of anti-HER2 antibodies. We report clinical translation utilizing an autologous adenoviral- transduced dendritic cell (DC) vaccine expressing human HER2 EC and TM domains (AdHER2ECTM) in adults with advanced metastatic tumors with 1-3+ HER2 expression. Methods: In this two-part phase I study (NCT01730118) subjects with HER2+ metastatic solid tumors naïve to HER2-targeted therapies (Part 1) or HER2+ treatment-experienced breast cancer (Part 2) received 5 doses of vaccine at Weeks 0, 4, 8, 16 and 24. Part 1 dose escalation involved 3 cohorts of 6 patients utilizing 5x10 6 , 10x10 6 and 20x10 6 viable DCs per dose, respectively. With no DLTs or evidence of cardiac toxicity, dose escalation to 40x10 6 viable DCs per dose was allowed in the Part 1 Expansion Cohort and Part 2 treatment was begun at a starting dose of 20x10 6 viable DCs per vaccine. Adjuvant muscle-invasive bladder cancer patients were allowed to enroll with safety documented out to 12 weeks in &gt; 10 treated patients. Re-staging was assessed using immune-related response criteria (irRC). Remaining study accrual: Part 1 (N = 9), Part 2 (N = 24). Results: A total of 27 cancer patients (7 colon, 6 breast, 5 ovarian, 3 bladder, 6 other) have received &gt; 2 vaccine doses (median 4): 19F, 8M, median age 60 yrs, median 3 prior treatment regimens (range 1-11); HER2 IHC 1+ N = 6, 2+ N = 9, 3+ N = 12. Of metastatic patients receiving 10x10 6 viable DCs per dose or higher, 7 of 19 (37%) had evidence of response by irRC: 1 CR (ongoing at 100 weeks), 1 PR (-71% lasting 44 weeks) and 5 SD (median duration 24 weeks, range 8 to 48 weeks). Two adjuvant bladder cancer patients remain without disease at 100 weeks. Adverse events were limited to local injection site reactions &lt; G2. Of patients with paired baseline samples, 40% (8/20), 83% (5/6) and 100% (2/2) exhibited decreases in circulating tumor cells at 12, 28 and 48 weeks, respectively. Conclusions: AdHER2 DC vaccination is safe and is associated with evidence of clinical benefit and anti-tumor activity. Clinical trial information: NCT01730118.
G-Augment: Searching for the Meta-Structure of Data Augmentation Policies for ASR (2023)

Data augmentation is a ubiquitous technique used to provide robustness to automatic speech recognition (ASR) training. However, even as so much of the ASR training process has become automated and more “end-to-end,” the data augmentation policy (what augmentation functions to use, and how to apply them) remains hand-crafted. We present G(raph)-Augment, a technique to define the augmentation space as directed acyclic graphs (DAGs) and search over this space to optimize the augmentation policy itself. We show that given the same computational budget, policies produced by G-Augment are able to perform better than SpecAugment policies obtained by random search on fine-tuning tasks on CHiME-6 and AMI. G-Augment is also able to establish a new state-of-the-art ASR performance on the CHiME-6 evaluation set (30.7% WER). We further demonstrate that G- Augment policies show better transfer properties across warm-start to cold-start training and model size compared to random-searched SpecAugment policies.
In vivo selection of metastatic lung cancer variants is associated with altered expression of notch and hedgehog stem cell proliferation programs (2007)

1260 Metastatic disease is the primary cause of death for most lung cancer patients and thus, understanding the molecular mechanism of metastatic behavior is key for developing new treatment strategies. There is considerable evidence that hematologic malignancies and some solid tumors harbor cancer stem cells. This leads to the hypothesis that this tumor stem cell component is essential for the metastatic behavior of the tumor. In developing methods to identify and target lung cancer stem cells we have derived metastatic variants of human lung cancer and tested them for stem cell characteristics compared to the parent tumor from which they were derived. In the present study, we used non-small cell lung cancer cell line NCI-H1299 (p53 null, N-RAS mutant, RASSF1A negative, p16 negative) to generate metastatic isogenic cell lines in xenograft models. We further compared the expression level of stem cell markers in these highly tumorigenic and metastatic cells with parental H1299 cells and determined if the in vivo activities are correlated with stem cell properties. H1299 cells were grown subcutaneously in nude mice, tumor cells harvested, grown in tissue culture for 10 days and re-implanted to form new tumors. This process was repeated at least one more times in 2 independent experiments to yield more than 30 different tumor lines. After this procedure we saw enhanced tumorigenicity and the ability to give metastases compared to the H1299 parental cells. DNA finger print tests confirmed the metastatic variants were all isogenic natures with H1299 cells. Quantitative real time PCR was used to determine the expression level of a panel of 21 stem cell proliferation markers. The highly metastatic lines significantly changed expression (2 to more than 10 fold) of stem cell markers in the notch (upregulated) and hedgehog (down regulated) pathways. We conclude that serial in vivo xenograft selection of non-small cell lung cancers leads to the identification of more tumorigenic and metastatic isogenic variants that have dramatically changed their expression of key stem cell proliferation signature genes. These gene products are thus therapeutic targets for lung cancer metastatic growth.
Organometallic materials for spacecraft use Final report (1965)

Thermal conductivity measurements of organometallic compounds used as additives for potting compounds and adhesives in unmanned spacecraft
Cerebellar α6‐subunit‐containing GABAAreceptors: a novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders (2018)

Positive allosteric modulation of cerebellar α<sub>6</sub> GABA<sub>A</sub> receptors rescued disrupted PPI by attenuating granule cell activity. α<sub>6</sub> GABA<sub>A</sub> receptor-selective PAMs are potential medicines for treating sensorimotor gating deficits in neuropsychiatric disorders. A mechanistic hypothesis is based on evidence for cerebellar contributions to cognitive functioning including sensorimotor gating.