gebhart/patrepeval huggingface dataset:
Vortex shedding-free strainers (2011)

The subject of the periodic vortex shedding behind bluff bodies, which exhibits oscillatory behaviour, is of direct relevance to many practical applications, e.g. pipelines and heat exchangers. Repetitive failures were occurring in associated piping components on the suction of a sales gas compressor. Available experimental investigations indicated the occurrences of vibrations at the predominant frequencies of 1500 and 3000 Hz in the compressor strainer pipes. Hence, this study is aimed at identifying the source of such high vibration levels. The study investigated the flow-induced vibrations in the compressor strainer pipe through numerical simulation of the flow in the pipe including the strainer, as well as structural modal analysis calculations for the strainer at steady-state conditions. Three different geometrical configurations were considered. The first strainer has a truncated-cone geometry with uniform size holes. The second is witch-hat geometry with uniform holes, while the third is a modified witch-hat configuration with non-uniform holes. The results obtained from the frequency analysis of the flow field downstream of strainers with the first two geometries indicated dominant amplitudes at 1500 Hz and appreciable excitations at its second harmonic. However, the results demonstrated that the dominant vibration amplitudes have been appreciably reduced for the third case of the modified witch-hat configuration with non-uniform holes.
Supplementary text from Large-scale Circulating microRNA Profiling for the Liquid Biopsy of Prostate Cancer (2023)

&lt;p&gt;Supplementary text&lt;/p&gt;
A Benchmark of Four Methods for Generating 360° Saliency Maps from Eye Tracking Data (2018)

International audience
'Only a Sith Thinks Like that': Llewellyn's 'Dueling Canons', Twenty One to Twenty Four (2010)

This is the fifth installment in a series of articles examining the famous twenty-eight pairs of “dueling canons” left to us in 1950 by Karl N. Llewellyn, “Remarks on the Theory of Appellate Decision and the Rules or Canons about How Statutes Are to Be Construed,” 3 VANDERBILT L.REV. 395 (1950). After more than half a century, Llewellyn’s assault on the legitimacy of canons remains an imposing landmark in statutory interpretation scholarship. The first four installments of this study, covering pairs 1 through 20, showed that Llewellyn’s thesis that for every canon of construction there was another to opposite effect did not stand up to examination. This study of pairs 21 through 24 continues the pattern. It includes the familiar principles noscitur a sociis (Parry 21) and ejusdem generis (Thrust 22), the “last antecedent” rule of anaphora (Pair 23), and the frailty of punctuation as a ground for interpretation (Pair 24). Llewellyn’s practice of taking a familiar principle of interpretation and splitting off its “unless” clause, then calling both parts canons and therefore contradictory again features. Only a determination to deny legislative intention in favor of interpretive formulae can save the contrariety of these pairs. And his strategy, familiar from pairs 1, 4, 6, 9, 12, 13, 15, 16, 17, and 18, of creating a parry from a variation on “. . . unless the legislature intended otherwise” appears again in pairs 22, 23, and 24. Pairs 21 to 24 demonstrate no greater problems for canons than did Pairs 1 to 20. Unless something dramatically different appears in the bottom of the batting order, Llewellyn’s celebrated list will prove not at all deconstructive, let alone devastatingly so.
Adaptive Stiffness Design for Multi-Material Structural System (2017)

Stiffness is one of basic characteristics of structural system, and is an important feature for structural design problems. Although it has been often recruited as the design objective or constraints, the structural optimality attained has guarantee only for the mechanical conditions considered at the design stage. The adaptive stiffness design for force-dependent stiffness is a concept to tailor the structural stiffness in accordance with the external load applied. The passive adaptive stiffness has been realized by using single conventional material only. In this article, it is evolved to the active one that enables us to switch the force-dependent stiffness actively in part in the context of the multi-material structural system. The topology design problem is formulated for the distribution of conventional and functional materials under the constraints of mean compliance and its switching point as the structure. The effectiveness of the proposed structural design concept is examined through numerical case studies solved by the SIMP method of topology design.
LinkedIn Salary: A System for Secure Collection and Presentation of\n Structured Compensation Insights to Job Seekers (2017)

Online professional social networks such as LinkedIn have enhanced the\nability of job seekers to discover and assess career opportunities, and the\nability of job providers to discover and assess potential candidates. For most\njob seekers, salary (or broadly compensation) is a crucial consideration in\nchoosing a new job. At the same time, job seekers face challenges in learning\nthe compensation associated with different jobs, given the sensitive nature of\ncompensation data and the dearth of reliable sources containing compensation\ndata. Towards the goal of helping the world's professionals optimize their\nearning potential through salary transparency, we present LinkedIn Salary, a\nsystem for collecting compensation information from LinkedIn members and\nproviding compensation insights to job seekers. We present the overall design\nand architecture, and describe the key components needed for the secure\ncollection, de-identification, and processing of compensation data, focusing on\nthe unique challenges associated with privacy and security. We perform an\nexperimental study with more than one year of compensation submission history\ndata collected from over 1.5 million LinkedIn members, thereby demonstrating\nthe tradeoffs between privacy and modeling needs. We also highlight the lessons\nlearned from the production deployment of this system at LinkedIn.\n
Lnk regulates integrin αIIbβ3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo (2009)

The nature of the in vivo cellular events underlying thrombus formation mediated by platelet activation remains unclear because of the absence of a modality for analysis. Lymphocyte adaptor protein (Lnk; also known as Sh2b3) is an adaptor protein that inhibits thrombopoietin-mediated signaling, and as a result, megakaryocyte and platelet counts are elevated in Lnk-/- mice. Here we describe an unanticipated role for Lnk in stabilizing thrombus formation and clarify the activities of Lnk in platelets transduced through integrin alphaIIbbeta3-mediated outside-in signaling. We equalized platelet counts in wild-type and Lnk-/- mice by using genetic depletion of Lnk and BM transplantation. Using FeCl3- or laser-induced injury and in vivo imaging that enabled observation of single platelet behavior and the multiple steps in thrombus formation, we determined that Lnk is an essential contributor to the stabilization of developing thrombi within vessels. Lnk-/- platelets exhibited a reduced ability to fully spread on fibrinogen and mediate clot retraction, reduced tyrosine phosphorylation of the beta3 integrin subunit, and reduced binding of Fyn to integrin alphaIIbbeta3. These results provide new insight into the mechanism of alphaIIbbeta3-based outside-in signaling, which appears to be coordinated in platelets by Lnk, Fyn, and integrins. Outside-in signaling modulators could represent new therapeutic targets for the prevention of cardiovascular events.
Cyclooxygenase-2 pathway correlates with vascular endothelial growth factor expression and tumor angiogenesis in hepatitis B virus-associated hepatocellular carcinoma (2004)

Evidence indicates that cyclooxygenase (COX)-2-derived prostaglandins (PGs) contribute to tumor growth by inducing angiogenesis. We investigated the role of COX-2 in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC). COX-2 and vascular endothelial growth factor (VEGF) expressions were examined by immunohistochemistry in 24 HBV-associated HCC. Tumor micro-vessel density (MVD) was assessed using CD34 immunohistochemistry. Hep3B HCC cell line, which carries integrated HBV genome, was stably transfected with human COX-2 cDNA. COX-2 and VEGF expressions were determined by Western blot while PG level was determined by ELISA. The effects of PGs on VEGF expression were also investigated. Expression of COX-2 and VEGF in HCC cells were observed in 19 (79%) and 16 (67%) cases, respectively. Well-differentiated HCC expressed COX-2 more strongly than less-differentiated HCC (p<0.001). COX-2 expression was found to correlate with VEGF expression and MVD (p=0.003 and 0.004, respectively). COX-2 overexpressing Hep3B clone had higher VEGF expression as compared to non-COX-2 expressing clone and parental cells. Treatment of the COX-2 overexpressing cells with a COX-2-selective inhibitor, NS-398 (10 microM), decreased PGE2 level and attenuated VEGF expression. Addition of PGE2 (10 microM) and the stable analog of PGI2, carbaprostacyclin (5 microM), to Hep3B cells also increased VEGF expression. Up-regulation of COX-2 correlates with VEGF expression and tumor angiogenesis in HBV-associated HCC. Moreover, COX-2 up-regulates VEGF expression in HCC cells, possibly via PGs production. Selective inhibition of COX-2 may block HCC associated angiogenesis and thus provides a rational approach for treatment of this malignancy.
Informed Inversion Approach to Electrical Resistivity Imaging in a Fractured‐Rock Setting (2012)

Characterization of fractured rock presents unique inversion challenges in electrical resistivity imaging (ERI). The standard, smoothness‐constrained inversion assumptions cannot adequately account for discrete fractures. Similarly, a borehole boundary is a sharp physical contrast and is often a conductive conduit that is typically not adequately incorporated into the inversion. We conducted synthetic studies to examine alternative ERI model parameterization approaches to better represent a fractured rock setting. An unstructured tetrahedral mesh was used for the forward modeling in order to optimize flexibility in the incorporation of boreholes and known fracture locations. Modeling such small‐scale features at the plot scale resulted in a finite element mesh with a large number of tetrahedral elements. Parallel processing was therefore used to solve these large, computationally‐extensive problems. Our synthetic simulations began with an uninformed smoothness‐constrained inversion, to which a priori information was incrementally added. We found major improvements when 1) disconnects were defined along boreholes and fractures and 2) a homogeneous resistivity is assumed along boreholes. Disconnects can be defined from borehole logging data along ERI boreholes if assumptions about fracture continuity along boreholes are made. Incorporating such disconnects has the potential to drastically improve imaging of electrical changes in fractured rock, particularly when monitoring the injection of amendments for contaminant remediation.
Abstract 2808: GD2-specific genetically engineered NK cell therapy is effective in a drug-resistant neuroblastoma xenograft mouse model (2014)

Abstract Background: Drug-resistant neuroblastoma remains a major challenge in pediatric oncology. A human NK cell line NK-92-scFv(ch14.18)-z engineered to express a GD2-specific chimeric antigen receptor (CAR) may help to address this problem. We investigated the cytotoxicity of NK-92-scFv(ch14.18)-z in a panel of GD2+ drug-resistant neuroblastoma cell lines and analyzed the anti-tumor efficacy of NK-92-scFv(ch14.18)-z in a drug-resistant neuroblastoma xenograft mouse model. Methods Cytotoxic activity of GD2-specific NK-92-scFv(ch14.18)-z towards a panel of GD2+ cell lines (CHLA-20, SK-N-BE(2), CHLA-136, CHLA-79, LA-N-1, LA-N-5), some of which exhibit partial or multidrug resistance, was analyzed in a 51Cr release assay. We investigated the impact of GD2 recognition on NK-92-scFv(ch14.18)-z-mediated lysis by blocking the CAR through the addition of an anti-idiotype antibody (anti-IdAb) and also by downregulating GD2 on target cells induced by the glucosylceramide synthase (GCS) inhibitor PPPP. We then employed ELISA to determine the production of effector molecules granzyme B and perforin in response to activation with immobilized GD2. Anti-tumor efficacy of NK-92-scFv(ch14.18)-z and IL-2 was analyzed in a drug-resistant GD2+ xenograft mouse model by peritumoral injections of the GD2-specific NK cell line. Results NK-92-scFv(ch14.18)-z effectively lysed GD2+ drug-resistant NB cell lines. This effect was almost completely abrogated by blocking the CAR with an anti-IdAb. Decreased GD2 expression on target cells also resulted in diminished lysis mediated by NK-92-scFv(ch14.18)-z. Quantification of granzyme B and perforin production with ELISA revealed that the plate-bound antigen GD2 alone was sufficient to induce activation of NK-92-scFv(ch14.18)-z. Importantly, repeated peritumoral subcutaneous injections of a combination of NK-92-scFv(ch14.18)-zeta and IL-2 significantly prolonged survival time of mice challenged with aggressively growing subcutaneous CHLA-20 tumors in a xenograft mouse model. Conclusions These encouraging results indicate that GD2-directed immunotherapy with genetically engineered NK cells is an appropriate treatment strategy especially in relapsed NB that exhibit drug resistance. Citation Format: Diana Seidel, Anastasia Shibina, C. Patrick Reynolds, Winfried S. Wels, Nicole Huebener, Holger N. Lode. GD2-specific genetically engineered NK cell therapy is effective in a drug-resistant neuroblastoma xenograft mouse model. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2808. doi:10.1158/1538-7445.AM2014-2808
Development of a rotationally magic trap for ultracold RbCs molecules (2022)

The 53rd Annual Meeting of the APS Division of Atomic, Molecular and Optical Physics will take place from May 30 – June 3, 2022 in Orlando, Fl, USA. <a href="https://morressier.zoom.us/j/89880865272?pwd=SWxTRGhra1ZOSDBrSkhVZDBzVDR6UT09/">Virtual Presenter Help Desk</a>
Nanocrystalline oxide films (1996)

Reference LPI-ARTICLE-1996-020View record in Web of Science Record created on 2006-02-21, modified on 2017-05-12
Durability of Synthetic Fibers in Fiber-Cement Building Materials (2003)

Peer Reviewed
Clover - Measuring the Cosmic Microwave Background B-mode Polarization (2009)

Clover is a UK-led experiment to measure the B-mode polarization of the cosmic microwave background. The instruments are currently under construction and deployment to the Pampa La Bola site in the Atacama Desert is planned for 2010. It consists of two 2-m class telescopes feeding background limited imaging arrays of ~100 dual polarization pixels at each of 97, 150 and 225 GHz. The waveguide and antenna fed TES bolometers are limited by unavoidable photon noise from the atmosphere, and read-out using NIST’s time domain multiplexing scheme. The entire instrument has been designed for exceptionally low systematic errors in polarization measurements, which has necessitated novel designs for the instrument optics, horn arrays, OMTs and detector feeds, as well as careful development of the scan strategy, field location and data analysis methods.The experiment aims to measure the polarization of the CMB with an angular resolution of 5.5′−8′across 1000 deg2 of sky (angular multipole range 20 &lt; l &lt; 1000) to a sensitivity of 8 μK-arcmin after foreground cleaning. If all systematics are adequately controlled this will allow the detection of the primordial B-mode CMB anisotropies down to tensor to scalar ratios of 0.03, as well as providing extremely accurate measurements of the CMB temperature, E-mode polarization, and B-mode lensing polarization. Detecting or constraining the level of the primordial B-mode signal will allow constraints to be placed on the energy scale of inflation, providing an unprecedented insight into the physics of the early Universe.We describe the current status of the Clover project, including the current instrument design and construction status, and the development of the novel technology involved.
Auto-pipeline (2021)

Recent work has made significant progress in helping users to automate single data preparation steps, such as string-transformations and table-manipulation operators (e.g., Join, GroupBy, Pivot, etc.). We in this work propose to automate multiple such steps end-to-end, by synthesizing complex data-pipelines with both string-transformations and table-manipulation operators. We propose a novel by-target paradigm that allows users to easily specify the desired pipeline, which is a significant departure from the traditional by-example paradigm. Using by-target, users would provide input tables (e.g., csv or json files), and point us to a "target table" (e.g., an existing database table or BI dashboard) to demonstrate how the output from the desired pipeline would schematically "look like". While the problem is seemingly under-specified, our unique insight is that implicit table constraints such as FDs and keys can be exploited to significantly constrain the space and make the problem tractable. We develop an AUTO-PIPELINE system that learns to synthesize pipelines using deep reinforcement-learning (DRL) and search. Experiments using a benchmark of 700 real pipelines crawled from GitHub and commercial vendors suggest that AUTO-PIPELINE can successfully synthesize around 70% of complex pipelines with up to 10 steps.
Improvements to software GNSS and reduced MEMS IMU measurement processing for urban navigation (2009)

This paper extends work previously performed in the area of integrating reduced-cluster MEMS IMU and GNSS measurements in urban navigation conditions. These reduced-cluster IMU configurations are i ...
Image-and-Spatial Transformer Networks for Structure-Guided Image Registration (2019)

Image registration with deep neural networks has become an active field of research and exciting avenue for a long standing problem in medical imaging. The goal is to learn a complex function that maps the appearance of input image pairs to parameters of a spatial transformation in order to align corresponding anatomical structures. We argue and show that the current direct, non-iterative approaches are sub-optimal, in particular if we seek accurate alignment of Structures-of-Interest (SoI). Information about SoI is often available at training time, for example, in form of segmentations or landmarks. We introduce a novel, generic framework, Image-and-Spatial Transformer Networks (ISTNs), to leverage SoI information allowing us to learn new image representations that are optimised for the downstream registration task. Thanks to these representations we can employ a test-specific, iterative refinement over the transformation parameters which yields highly accurate registration even with very limited training data. Performance is demonstrated on pairwise 3D brain registration and illustrative synthetic data.
The future of stenting (1997)

Summary. The era of intracoronary stenting has arrived, with two proven clinical applications: as bail-out for failed angioplasty, and for long-term effects on decreasing restenosis. Stent restenosis occurs because of neointimal hyperplasia, since the stent effectively deals with remodelling. Stents of the current generation exhibit only mechanical effects, and lack biologic activity to inhibit neointimal thickness. The future of stenting centres on improved mechanical and delivery features, as well as developing biological activity. In the future the stent will come to fully realize its full potential, with potent mechanical and biological properties.
S1c2-3 Conformational fluctuations of Btk SH3 domain revealed by variable-pressure NMR(S1-c2: "Protein Hydration and Dynamics Studied on Pressure-axis",Symposia,Abstract,Meeting Program of EABS & BSJ 2006) (2006)

The deep-
Extracellular potassium modifies the structure of kidney epithelial cells in culture (1985)

In animals fed a K-deficient diet, alterations in kidney cell structure and function occur in association with changes in the ionic composition of the extracellular fluid. The hypothesis that the extracellular K concentration mediates these changes in renal tissue was tested in cultures of monkey kidney epithelial cells (BSC-1 line) by reducing the K concentration of the culture medium from the control value of 5.4 to 3.2 mM. Exposure of BSC-1 cells to low-K medium raised the maximal rate of uptake for L-glutamic acid by 39% without a change in apparent Km. To determine whether this alteration in plasma membrane function had a structural correlate, studies of the cell surface were performed using scanning and transmission electron microscopy. Morphometric analysis of scanning electron micrographs revealed that the number of microvilli per cell per unit surface area was 45% greater in cells exposed to low-K medium for 3 min than those exposed to control medium. This observation was confirmed by transmission electron microscopy. The results indicate that an alteration in the extracellular K concentration per se can modify specific structural and functional characteristics of kidney epithelial cells.
Experimental Simulation of a Film Cooled Turbine Blade Leading Edge Including Thermal Barrier Coating Effects (2010)

For this study, a simulated film cooled turbine blade leading edge, constructed of a special high conductivity material, was used to determine the normalized “metal temperature” representative of actual engine conditions. The Biot number for the model was matched to that for operational engine conditions, ensuring that the normalized wall temperature, i.e., the overall effectiveness, was matched to that for the engine. Measurements of overall effectiveness were made for models with and without thermal barrier coating (TBC) at various operating conditions. This was the first study to experimentally simulate TBC and the effects on overall effectiveness. Two models were used: one with a single row of holes along the stagnation line, and the second with three rows of holes straddling the stagnation line. Film cooling was operated using a density ratio of 1.5 and for range of blowing ratios from M=0.5 to M=3.0. Both models were tested using a range of angles of attack from 0.0 deg to ±5.0 deg. As expected, the TBC coated models had significantly higher external surface temperatures, but lower metal temperatures. These experimental results provide a unique database for evaluating numerical simulations of the effects of TBC on leading edge film cooling performance.
Abstract 17932: Diabetic Cardiomyopathy in Mice is Characterized by Defects in Myocyte Turnover Measured by Microdosing of 14C-Labeled Thymidine (2013)

Insulin-dependent diabetes mellitus was induced in mice by streptozotocin administration (175 mg/kg bw). Blood glucose was measured daily and when it reached 450 mg/dl, ~5-7 days later, 300 pCi 14C-thymidine was given intramuscularly to label forming cardiomyocytes. Control mice were similarly treated. This protocol results in a pulse labeling of replicating cells, since thymidine disappears from the circulation in less than one hour; the half-life of this nucleotide is ~15 minutes. Control and diabetic mice were sacrificed at 1, 3, 5, 10, 20, 30, 60, and 90 days after the injection of 14C-thymidine and the heart was collected. Left ventricular myocytes were isolated by enzymatic digestion, purified by differential centrifugation, and the DNA was extracted for the measurement of the kinetics of 14C concentration by Accelerator Mass Spectrometry. This is the only methodology that allows the assessment of trace-amount of 14C in the DNA. In non-diabetic control hearts, 14C concentration in the myocyte DNA in...