gebhart/patrepeval huggingface dataset:
Single Nucleotide Polymorphism Typing ofBacillus anthracisfrom Sverdlovsk Tissue (2008)

A small number of conserved canonical single nucleotide polymorphisms (canSNP) that define major phylogenetic branches for Bacillus anthracis were used to place a Sverdlovsk patient's B. anthracis genotype into 1 of 12 subgroups. Reconstruction of the pagA gene also showed a unique SNP that defines a new lineage for B. anthracis.
An Active Ripple Filtering Technique for Improving Common-Mode Inductor Performance (2004)

Active ripple filtering is the replacement of large passive components in power filter circuits with smaller passive components and active control circuitry. This letter focuses on common-mode filters, where a large common-mode inductor (choke) is replaced by two smaller chokes and active op-amp control. The technique is appropriate when improved attenuation is required at relatively low frequencies and the high-frequency filtering requirements are easily met. Smaller chokes save significantly in material and winding costs. The technique is more advantageous if wire-wound chokes can be replaced by planar printed circuit board chokes. The use of the technique in an automotive electromagnetic interference (EMI) filter application is explored in detail.
Donor-derived skeletal muscle precursor cells improve muscle functions in a murine model of X-linked myotubular myopathy (2015)

Lim, Hyun Ju; Joo, Sunyoung MD; Jackson, John D. PhD; Eckman, Delrae; Pierson, Christopher R. MD, PhD; Childers, Martin DO, PhD; Yoo, James MD, PhD; Atala, Anthony MD, FACS Author Information
Performance Optimization of High Ni (≥90%) Cathode Materials: Synthesis & Modification (2022)

The significant growth rate of the electric vehicles (EVs) market, powered by rechargeable lithium-ion batteries (LIBs), in favor over of the internal combustion engine (ICE), represents an opportunity to massively reduce CO 2 emissions and help limit global warming issues. EVs should have a similar performance to that of ICE-powered vehicles in terms of fulfilling driving range as well as lifetime of the battery to appeal the potential consumers. However, the driving range of EV’s is limited by the battery performance, which is related to the properties of the cathode material. Therefore, the development of advanced cathodes is needed. Current state-of-the-art, Li-ion cathodes for EV batteries are derived from layered LiNiO 2 (LNO) by substitution of Ni with other elements such as Mn, Co, and Al – so called LiNi x Mn y Co z Al 1-x-y-z O 2 (NMCA). Substitutions are used to offset the inferior structural stability and poor cycle-life performance of typically-produced, high-capacity NMCAs. In this regard, pure LNO has been reported as a baseline material for gauging the improvements, via doping/coating strategies, for the NMCA-class of cathodes. However, for the purposes of a fully understanding the roles of Mn, Co, Al, and other dopants in NMCAs, the development of a truly state-of-the-art, LNO cathode should be accomplished. This presentation will discuss the various parameters affecting the synthesis and performance of LNO and LNO-based oxides, from precursors to final products, and the strategies that have been pursued at Argonne National Laboratory towards the realization of high-performance LNO baselines and derivatives thereof. Their potential applicability to battery applications will be also reviewed.
TCP/IP Field Behavior (2006)

This memo describes TCP/IP field behavior in the context of header
compression. Header compression is possible because most header fields
do not vary randomly from packet to packet. Many of the fields exhibit
static behavior or change in a more or less predictable way. When a
header compression scheme is designed, it is of fundamental importance
to understand the behavior of the fields in detail. An example of this
analysis can be seen in RFC 3095. This memo performs a similar role
for the compression of TCP/IP headers. This memo provides information
for the Internet community.
Immunologic reconstitution by interleukin-2: facts and open questions. (2000)

Interleukin-2 (IL-2), one of the most potent immunoregulatory and inflammatory cytokines, is being tested in phase III clinical trials in order to demonstrate its efficacy in combination with current antiviral agents in preventing the occurrence of opportunistic infections and death in individuals infected by the human immunodeficiency virus (HIV). In the meantime, its capacity to boost the number of CD4+ T cells in peripheral blood has been confirmed by a number of individual phase I/II trials conducted in different countries by independent investigators. In the face of this remarkable result, little is known of the effects exerted by this cytokine once administered to infected individuals in terms of its impact on different immunologic functions. The recent acquisitions on the important role played by latently infected cells in in vivo infection in reinitiating HIV replication and cytopathicity once antiviral therapy is suspended or becomes suboptimal, has shed new light on the possibility of utilizing immunologic strategies, including IL-2, for eradicating the virus from latent reservoirs. Results from a clinical trial conducted at our Institute indicate a decrease in lymphocyte-associated HIV DNA after IL-2 administration, supporting this hypothesis.
A polyalanine peptide derived from polar fish with anti-infectious activities (2016)

Due to the growing concern about antibiotic-resistant microbial infections, increasing support has been given to new drug discovery programs. A promising alternative to counter bacterial infections includes the antimicrobial peptides (AMPs), which have emerged as model molecules for rational design strategies. Here we focused on the study of Pa-MAP 1.9, a rationally designed AMP derived from the polar fish Pleuronectes americanus. Pa-MAP 1.9 was active against Gram-negative planktonic bacteria and biofilms, without being cytotoxic to mammalian cells. By using AFM, leakage assays, CD spectroscopy and in silico tools, we found that Pa-MAP 1.9 may be acting both on intracellular targets and on the bacterial surface, also being more efficient at interacting with anionic LUVs mimicking Gram-negative bacterial surface, where this peptide adopts α-helical conformations, than cholesterol-enriched LUVs mimicking mammalian cells. Thus, as bacteria present varied physiological features that favor antibiotic-resistance, Pa-MAP 1.9 could be a promising candidate in the development of tools against infections caused by pathogenic bacteria.
High angular resolution 30 microns observations of the Galactic Center (1995)

We have mapped the central 2 min (5 pc) of the Galaxy with 4 sec resolution at 30 microns, using the MSFC bolometer array on the NASA Infrared Telescope Facility at Mauna Kea. Complementary maps at 10 and 20 microns covering the same region were obtained contemporaneously with the same instrumentation. The maps encompass both the central cavity at the very center of the Galaxy and the disk of gas and dust which surrounds it. Our data show thermal emissions from dust particles within the cavity and - for the first time at this resolution - within the disk itself. The emission peaks at the position of IRS1 at all three wavelengths, and the 20/30 micron brightness ratio falls uniformly from this peak toward the outer regions of the source. The 30 micron emission correlates well with the HCN emission in the southwest portion of the circumnuclear disk and with the (O I) emission in the north. No feature is apparent at the position of SgrA at any of the three wavelengths. The circumnuclear disk was discovered from the KAO and has been extensively studied in both continuum and line emission in numerous subsequent flights. The poster will attempt to show how these latest ground-based observations intersect and build upon these airborne investigations.
Topical Mucosal Vaccination with Angiotensin (1-7) and Feline Immunodeficiency Virus Induces Secretory IgA Responses (2015)

Background: Pre-existing mucosal generated secretory IgA antibodies may prevent transmission of HIV. The present study aimed to characterize mucosal antibodies generated following topical vaccination with a novel mucosal adjuvant, angiotensin (1-7), in combination with a killed feline immunodeficiency virus (FIV) vaccine used as a model antigen.
A Chip-Scale Cooling Scheme With Integrated Heat Sink and Thermal-Fluidic I/O Interconnects (2005)

We demonstrate a prototype chip-scale microfluidic cooling scheme. CMOS compatible processes allow the monolithic integration of the microchannel heat sink into the backside of a Si chip at low temperature (≤260°C). At the front side of a chip, fine pitch area-array solder bumps are fabricated by electroplating for high-density electrical I/O interconnection, while a peripheral array of micro polymer pipes are fabricated as thermal-fluidic I/O interconnects. The resulting “microfluidic flip chip” can be bonded onto a liquid-cooled board substrate using conventional flip-chip assembly processes. The cooling liquid can, therefore, be transferred into a Si chip directly from the board-level manifolds to alleviate the thermal interface issues. This paper was also originally published as part of the Proceedings of the ASME 2005 Heat Transfer Summer Conference.
Improved Performance of a Multipinhole SPECT for DAT Imaging by Increasing Number of Pinholes at the Expense of Increased Multiplexing (2020)

SPECT imaging of dopamine transporters (DAT) in the brain is a widely utilized study to improve the diagnosis of Parkinsonian syndromes, where conventional (parallel-hole and fan-beam) collimators on dual-head scanners are commonly employed. We have designed a multi-pinhole (MPH) collimator to improve the performance of DAT imaging. The MPH collimator focuses on the striatum and hence offers a better trade-off for sensitivity and spatial resolution than the conventional collimators within this clinically most relevant region for DAT imaging. Our original MPH design consisted of 9 pinholes with a background-to-striatal (Bkg/Str) projection multiplexing of 1% only. In this simulation study, we investigated whether further improvements in the performance of MPH imaging could be obtained by increasing the number of pinholes, hence by enhancing the sensitivity and sampling, despite the ambiguity in reconstructing images due to increased multiplexing. We performed analytic simulations of the MPH configurations with 9, 13, and 16 pinholes (aperture diameters: 4-6mm) using a digital phantom modeling DAT imaging. Our quantitative analyses indicated that using 13 (Bkg/Str: 12%) and 16 (Bkg/Str: 22%) pinholes provided better performance than the original 9-pinhole configuration for the acquisition with 2 or 4 angular views, but a similar performance with 8 and 16 views.
The role of PRP8 protein in nuclear pre-mRNA splicing in yeast (1995)

The removal of introns from precursor messenger RNAs occurs in a large complex, the spliceosome, that contains many proteins and five small nuclear RNAs (snRNAs). The snRNAs interact with the intron-containing substrate RNA and with each other to form a dynamic network of RNA interactions that define the intron and promote splicing. There is evidence that protein splicing factors play important roles in regulating RNA interactions in the spliceosome. PRP8 is a highly conserved protein that is associated in particles with the U5 snRNA and directly binds the substrate RNA in spliceosomes. UV crosslinking has been used to map the binding sites, and shows extensive interaction between PRP8 protein and the 5' exon prior to the first step of splicing and with the 3' splice site region subsequently. It is proposed that PRP8 protein may stabilize fragile interactions between the U5 snRNA and exon sequences at the splice sites, to anchor and align them in the catalytic centre of the spliceosome.
Crystal structure ofcatena-poly[[chlorido(4,4′-dimethyl-2,2′-bipyridine-κ2N,N′)copper(II)]-μ-chlorido] (2015)

The title compound, [CuCl2(C12H12N2)] n , was obtained via a DMSO-mediated dehydration of Cu(4,4'-dimethyl-2,2'-bi-pyridine)-copper(II)·0.25H2O. The central Cu(II) atom is coordinated in a distorted trigonal-bipyramidal geometry by two N atoms of a chelating 4,4'-dimethyl-2,2'-bi-pyridine ligand [average Cu-N = 2.03 (3) Å] and three Cl atoms, one terminal with a short Cu-Cl bond of 2.2506 (10) Å, and two symmetry-equivalent and bridging bonds. The bridging Cl atom links the Cu(II) ions into chains parallel to [001] via one medium and one long Cu-Cl bond [2.3320 (10) and 2.5623 (9) Å]. The structure displays both inter- and intra-molecular C-H⋯Cl hydrogen bonding.
Theoretical study on stochastic defect generation in chemically amplified resist process for extreme ultraviolet lithography (2014)

For high-resolution lithography using highly sensitive resists, the stochastic effect is a serious concern. In this study, the formation of line-and-space patterns was simulated by a Monte Carlo method on the basis of the sensitization mechanisms of extreme ultraviolet resists to investigate the stochastic generation of the defects of resist patterns such as bridges and pinching. It was found that the probability of defect generation rapidly increases with the reduction of feature size. The suppression of stochastic defect generation is an urgent task for the realization of high-volume production of semiconductor devices with the critical dimension of 11 nm.
Iron Homeostasis and Inflammatory Status in Mice Deficient for the Cystic Fibrosis Transmembrane Regulator (2015)

These results indicate that in CF, the lung do not predominantly contributes to the systemic ferritin deficiency and we propose the spleen as the major organ responsible for hypoferritinemia in the KO mouse. These results should provide a better understanding of iron dysregulation in CF patients where treating or not iron deficiency remains a challenging question.
Total Synthesis of (±)-Aplykurodinone-1: Traceless Stereochemical Guidance (2010)

The total synthesis of the highly degraded steroidal natural product, aplykurodinone-1 (&lt;b&gt;1&lt;/b&gt;), has been accomplished. Key features include a one-flask hydrolysis/retro-aldol/iodolactonization sequence to excise the C&lt;sub&gt;8&lt;/sub&gt; hydroxymethylene functionality with retention of stereochemistry and the stereoselective installation of the C&lt;sub&gt;13&lt;/sub&gt; methyl group through hydrogenation with homogeneous catalyst.
ChemInform Abstract: N‐(2‐(4‐Hydroxyphenyl)ethyl)‐4‐chlorocinnamide: A Novel Antagonist at the 1A/2B NMDA Receptor Subtype. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
P2Y4-Mediated Regulation of Na+Absorption in the Reissner's Membrane of the Cochlea (2010)

The epithelial cells of Reissner's membrane (RM) are capable of transporting Na(+) out of endolymph via epithelial Na(+) channel (ENaC). However, much remains to be known as to mechanism of regulation of Na(+) absorption in RM. We investigated P2Y signaling as a possible regulatory mechanism of ENaC in gerbil RM using voltage-sensitive vibrating probe technique and immunohistochemistry. Results showed that UTP induced partial inhibition of the amiloride-sensitive short-circuit current but did not change short-circuit current when applied in the presence of amiloride. The inhibitory effect of UTP was not completely reversible in minutes. The response to UTP was inhibited by reactive blue-2 and 2',3'-O-(4-benzoylbenzoyl)adenosine 5'-triphosphate but not by suramin or pyridoxalphosphate-6-azophenyl-2', 4'-disulfonic acid, which indicates this P2Y receptor as the P2Y(4) subtype. The phospholipase C (PLC) inhibitors 1-[6[[(17beta)-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine markedly inhibited the effect of UTP on ENaC. In contrast, neither modulation of protein kinase C nor application of 2-aminoehoxydiphenyl borate affected P2Y(4)-mediated inhibition of ENaC. Immunoreactive staining for P2Y(4) was observed in the RM, apical membrane of stria vascularis, spiral ligament, and organ of Corti, including outer hair cell, inner hair cell, outer pillar cell, Deiters' cell, and Hensen cell. These results suggest that the physiological role of P2Y(4) receptor in RM is likely to regulate Na(+) homeostasis in the endolymph. The acute inhibition of ENaC activity by activation of P2Y(4) receptor is possibly mediated by decrease of phosphatidylinositol 4,5-biphosphate in the plasma membrane through PLC activation.
B (2009)

This chapter contains sections titled: Bag-in-Box, Dry Product Bag-in-Box, Liquid Product Bagmaking Machinery Bags, Bulk, Flexible Intermediate Bulk Containers Bags, Multiwall Bags, Plastic Bands, Shrink Barrels Barrier and Overprint Coatings Barrier Polymers Biobased Materials Biofilm Development on Packaging Materials Biosensor Technology for Food, Packaging Applications Blow Molding Bottle Design, Plastic Boxes, Corrugated Boxes, Rigid, Paperboard Boxes, Rigid, Plastic Boxes, Solid-Fiber Boxes, Wood Bulk Packaging Bibliography
The Chemical Basis of Fungal Bioluminescence (2015)

Abstract Many species of fungi naturally produce light, a phenomenon known as bioluminescence, however, the fungal substrates used in the chemical reactions that produce light have not been reported. We identified the fungal compound luciferin 3‐hydroxyhispidin, which is biosynthesized by oxidation of the precursor hispidin, a known fungal and plant secondary metabolite. The fungal luciferin does not share structural similarity with the other eight known luciferins. Furthermore, it was shown that 3‐hydroxyhispidin leads to bioluminescence in extracts from four diverse genera of luminous fungi, thus suggesting a common biochemical mechanism for fungal bioluminescence.
Intramolecular Pyrene Excimer Probing the Sol-Gel Process (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntramolecular Pyrene Excimer Probing the Sol-Gel ProcessL. M. Ilharco, A. M. Santos, M. J. Silva, and J. M. G. MartinhoCite this: Langmuir 1995, 11, 7, 2419–2422Publication Date (Print):July 1, 1995Publication History Published online1 May 2002Published inissue 1 July 1995https://pubs.acs.org/doi/10.1021/la00007a018https://doi.org/10.1021/la00007a018research-articleACS PublicationsRequest reuse permissionsArticle Views261Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ALD La-Based Oxides for Vt-Tuning in High-K/Metal Gate Stacks (2007)

Accurate thickness and composition control for ultra-thin films is demonstrated for the atomic layer deposition (ALD) of La2O3 and HfLaO. Growth studies indicate a linear growth without substrate inhibition for La2O3 and HfLaO ALD on HfSiO and hydroxylated SiO2, respectively. Layer closure studies on HfSiO show a fast La2O3 layer closure. Vt-tuning in a high thermal budget NMOS transistor flow is established (i) by inserting sub-nm La2O3 capping layers between the HfSiON gate oxide and the TaCx metal electrode and (ii) by replacing the HfSiON gate oxide film by HfLaO. Changing the La2O3 capping layer thickness from 0 till 1 nm, results in tunable Vt-shifts up to ~ 600mV while retaining low equivalent oxide thickness (EOT), high mobility, and low gate leakage current. Hf-rich HfLaO gate dielectric layers resulted in a Vt-shift of ~ 250 mV and EOT values down to 1.1 nm.
Flap Ischemia after Pedicled Tissue Transfer to a Lateral Thigh Wound: An Example of Complication Assessment Using the End Result System of E. A. Codman (2007)

Greene, Arin K. M.D., M.M.Sc.; Austen, William G. Jr M.D.; May, James W. Jr M.D. Author Information
Generating Evidence on Spinal Cord Stimulation for Failed Back Surgery Syndrome: Not Yet Fully Charged. Clin J Pain. 2008;24:757–758 (2009)

*Department of Neurosurgery, The Johns Hopkins University School of Medicine, and LifeBridge Health Brain & Spine Institute †The Neuromodulation Foundation Incorporated, Baltimore, MD ‡Department of Health Services Research, Peninsula Medical School, Universities of Exeter & Plymouth Exeter, United Kingdom
Modelling and Device Simulation of Photonic Crystal Surface Emitting Lasers Based on Modal Index Analysis (2018)

We present a novel semi-analytical method for modelling the resonances of photonic crystal surface emitting lasers (PCSELs) using modal index analysis. This method shows very good agreement with other modelling techniques in terms of zone centre mode calculations, with the added advantages of computational simplicity, calculating threshold gain, incorporation of spatially and spectrally dependant gain, and rapid analysis of finite structures. We are able to model the effect of external lateral feedback and simulations indicate that the near-field peak can be electronically displaced, paving the way to beam steering.
A computational approach to the psychiatric diagnosis (2016)

One of the most important aims of computational psychiatry (CP) is to provide computational tools to help with earlier diagnoses in psychiatric disorders. CP implements different computer science tools to assist the medical professional in the path to the diagnoses. The paradigm where CP works is to understand the patient as a producer of data from differents cognitive levels. These data could come from physiological studies (as functional magnetic resonance imaging or electroencephalography) or from more abstract levels like patients' thoughts. In our research line, we use spontaneous speech as source as a window into the patient's minds.