gebhart/patrepeval huggingface dataset:
The Influence of Phosphane Ligands on the Versatility of Ruthenium–Indenylidene Complexes in Metathesis (2010)

The aim of the present study is to develop readily available and stable pre-catalysts that could be easily prepared on large scale from simple starting materials. Based on the hypothesis that substitution of classical PCy(3) with phosphanes of varying electron-donating properties could be a straightforward manner to improve catalytic activity, a methodical study dealing with the effect of phosphane fine-tuning in ruthenium-indenylidene catalysts was performed. Challenged to establish how the electronic properties of para-substituted phosphane ligands translate into catalyst activity, the versatile behaviour of these new ruthenium-indenylidene complexes was investigated for a number of metathesis reactions.
In Situ Studies of Ion Transport in Microporous Supercapacitor Electrodes at Ultralow Temperatures (2012)

Abstract The ability to quickly store and deliver a significant amount of electrical energy at ultralow temperatures is critical for the energy‐efficient operation of high altitude aircraft and spacecraft, exploration of natural resources in polar regions and extreme altitudes, and astronomical observatories exposed to ultralow temperatures. Commercial high‐power electrochemical capacitors fail to operate at temperatures below –40 °C. According to conventional wisdom, mesoporous electrochemical capacitor electrodes with pores large enough to accommodate fully solvated ions are needed for sufficiently rapid ion transport at lower temperatures. It is demonstrated that strictly microporous carbon electrodes with much higher volumetric capacitance can be efficiently used at temperatures as low as –70 °C. The critical parameters, with respect to electrolyte properties and electrode porosity and microstructure, needed for achieving both rapid ion transport and efficient ion electroadsorption in porous carbons are discussed. As an example, the fabrication of an electrochemical capacitor with an outstanding performance at temperatures as low as –60 and –70 °C is demonstrated. At such low temperatures the capacitance of the synthesized electrodes is up to 123 F g −1 (≈76 F cm −3 ), which is 50–100% higher than that of the most common commercial electrochemical capacitor electrode at room temperature. At –60 °C selected cells based on ≈0.2 mm electrodes exhibited characteristic charge–discharge time constants of less than 9 s, which is faster than the majority of commercial devices at room temperature. The achieved combination of high energy and power densities at such ultralow temperatures is unprecedented and extremely promising for the advancement of energy storage systems.
Evolution and expression of chimeric POTE–actin genes in the human genome (2006)

We previously described a primate-specific gene family, POTE, that is expressed in many cancers but in a limited number of normal organs. The 13 POTE genes are dispersed among eight different chromosomes and evolved by duplications and remodeling of the human genome from an ancestral gene, ANKRD26. Based on sequence similarity, the POTE gene family members can be divided into three groups. By genome database searches, we identified an actin retroposon insertion at the carboxyl terminus of one of the ancestral POTE paralogs. By Northern blot analysis, we identified the expected 7.5-kb POTE-actin chimeric transcript in a breast cancer cell line. The protein encoded by the POTE-actin transcript is predicted to be 120 kDa in size. Using anti-POTE mAbs that recognize the amino-terminal portion of the POTE protein, we detected the 120-kDa POTE-actin fusion protein in breast cancer cell lines known to express the fusion transcript. These data demonstrate that insertion of a retroposon produced an altered functional POTE gene. This example indicates that new functional human genes can evolve by insertion of retroposons.
Million-scale Derivation of Semantic Relations from a Manually Constructed Predicate Taxonomy (2014)

We manually created a semantic taxonomy called Phased Predicate Template Taxonomy (PPTT) that covers 12,023 predicate templates (i.e., predicates with one argument slot like “rescue X”) and derived from it various semantic relations between these templates on a million-instance scale (70%-80 % precision level). The derived relations include entailment (e.g., rescue X⊃X is alive), happens-before (e.g., buy X⇒drink X), and a novel relation type anomalous obstruction (e.g., X is sold out;cannot buy X). Such derivation became possible thanks to PPTT’s design and the use of statistical methods. 1
A Proton-Responsive Annulated Mesoionic Carbene (MIC) Scaffold on Ir Complex for Proton/Hydride Shuttle: An Experimental and Computational Investigation on Reductive Amination of Aldehyde (2020)

A Cp*Ir(III) complex (1) bearing a proton-responsive hydroxy unit on an annulated imidazo[1,2-a][1,8]naphthyridine based mesoionic carbene scaffold was synthesized by two different synthetic routes. The molecular structure of 1 revealed an anionic lactam form of the ligand. The acid–base equilibrium between the lactam-lactim tautomers on the ligand scaffold was examined by 1H NMR and UV–vis spectra. The pKa of the appendage −OH group in the lactim form of 1 was estimated to assess the proton transfer property of the catalyst. The catalytic efficacy of 1 for reductive amination of aldehyde was evaluated by utilizing three different hydrogen sources: molecular H2, iPrOH/KOtBu combination, and HCOOH/Et3N (5:2) azeotropic mixture. The HCOOH/Et3N (5:2) azeotropic mixture protocol was found to be the best among the three different hydrogenation methods. Catalyst 1 hydrogenates imines chemoselectively over carbonyls under the reaction conditions. A range of aldehydes was reductively aminated to the corresponding secondary amines using the HCOOH/Et3N (5:2) azeotropic mixture. Further, catalyst 1 showed high efficiency for the reduction of a wide variety of N-heterocyclic imine derivatives. The lactam-lactim tautomerization of the ligand system is proposed for direct hydrogenation, whereas only the lactam form operates in the strongly basic medium (iPrOH/KOtBu). Under HCOOH/Et3N (5:2) conditions, the lactam scaffold is not protonated; rather, an outer-sphere hydride transfer from formate to the Ir is proposed, which is supported by 1H NMR and DFT calculations. Finally, ligand-promoted hydride transfer from metal-hydride to the protonated imine affords the corresponding amine. A close agreement between the experimentally estimated and computed thermodynamic/kinetic parameters gives credence to the metal-ligand cooperative mechanism for the imine hydrogenation reaction using the HCOOH/Et3N (5:2) azeotropic mixture.
Idle Tones Reduction in Digital Single-Bit ΣΔ Modulators (2019)

Single-bit ΣΔ modulators are prone to exhibit idle tones in stable operation. In audio applications the human hear can perceive this tonal behavior degrading the quality of the application. Classical solutions to overcome this problem are the use of dithering signals or chaotic modulators. In this work we compare these methods with the addition of a Fractional Delay FIR filter. The proposed technique is analyzed in terms of NTF modification and complexity, as well as the effectiveness of the technique in reducing high frequency idle tones; the impact on the modulator performance is also studied.
ChemInform Abstract: Mild Synthesis of Enantiomerically Pure Imidazo‐[1,2‐a]azepines Mediated by Yb(OTf)3. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Lateralization in Reverse Shoulder Arthroplasty (2021)

Indications for Reverse Shoulder Arthroplasty (RSA) have been extended over the last 25 years, and RSA has become the most frequently implanted shoulder arthroplasty worldwide. The initial Grammont design with medialization of the joint center of rotation (JCOR), placement of the JCOR at the bone-implant interface, distalization and semi-constrained configuration has been associated with drawbacks such as reduced rotation and range of motion (ROM), notching, instability and loss of shoulder contour. This review summarizes new strategies to overcome these drawbacks and analyzes the use of glenoid-sided, humeral-sided or global bipolar lateralization, which are applied differently by surgeons and current implant manufacturers. Advantages and drawbacks are discussed. There is evidence that lateralization addresses the initial drawbacks of the Grammont design, improving stability, rates of notching, ROM and shoulder contour, but the ideal extent of lateralization of the glenoid and humerus remains unclear, as well as the maximal acceptable joint reaction force after reduction. Overstuffing and spine of scapula fractures are potential risks. CT-based 3D planning as well as artificial intelligence will help surgeons with planning and execution of appropriate lateralization in RSA. Long-term follow-up of lateralization with new implant designs and implantation strategies is needed.
Yinyang K-Means: A Drop-In Replacement of the Classic K-Means with Consistent Speedup (2015)

This paper presents Yinyang K-means, a new algorithm for K-means clustering. By cluster-ing the centers in the initial stage, and lever-aging efficiently maintained lower and upper bounds between a point and centers, it more effectively avoids unnecessary distance calcula-tions than prior algorithms. It significantly out-performs prior K-means algorithms consistently across all experimented data sets, cluster num-bers, and machine configurations. The consis-tent, superior performance—plus its simplicity, user-control of overheads, and guarantee in pro-ducing the same clustering results as the stan-dard K-means does—makes Yinyang K-means a drop-in replacement of the classic K-means with an order of magnitude higher performance. 1.
Safe Task Interruption for FPGAs (2019)

Saving and restoring the state of an FPGA task in an orderly manner is essential for enabling hardware checkpointing and context switching. However, it requires task interruption, and stopping a task at an arbitrary time can cause several hazards including deadlock and data loss. In this work, we build a context switching simulator to simulate and identify these hazards. In addition, we introduce design rules that should be followed to achieve safe task interruption, and propose task wrappers that can be placed around an FPGA task to implement these rules.
Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions (2007)

Convection-enhanced delivery (CED) is a novel drug delivery technique that uses positive infusion pressure to deliver therapeutic agents directly into the interstitial spaces of the brain. Despite the promise of CED, clinical trials have demonstrated that target-tissue anatomy and patient-specific physiology play a major role in drug distribution using this technique. In this study, we retrospectively tested the ability of a software algorithm using MR diffusion tensor imaging to predict patient-specific drug distributions by CED. A tumor-targeted cytotoxin, cintredekin besudotox (interleukin 13-PE38QQR), was coinfused with iodine 123-labeled human serum albumin (123I-HSA), in patients with recurrent malignant gliomas. The spatial distribution of 123I-HSA was then compared to a drug distribution simulation provided by the software algorithm. The algorithm had a high sensitivity (71.4%) and specificity (100%) for identifying the high proportion (7 of 14) of catheter trajectories that failed to deliver drug into the desired anatomical region (p = 0.021). This usually occurred when catheter trajectories crossed deep sulci, resulting in leak of the infusate into the subarachnoid cerebrospinal fluid space. The mean concordance of the volume of distribution at the 50% isodose level between the actual 123I-HSA distribution and simulation was 65.75% (95% confidence interval [CI], 52.0%-79.5%), and the mean maximal inplane deviation was less than 8.5 mm (95% CI, 4.0-13.0 mm). The use of this simulation algorithm was considered clinically useful in 84.6% of catheters. Routine use of this algorithm, and its further developments, should improve prospective selection of catheter trajectories, and thereby improve the efficacy of drugs delivered by this promising technique.
Fabrication and characterization of melt-processed YBCO (1996)

Large domain YBCO are fabricated by using a melt processing technique for magnetic levitation applications. A Nd{sub 1+x}Ba{sub 2{minus}x}Cu{sub 3}O{sub y} seed is used to initiate grain growth and to control the orientation of YBCO grains. Samples as large as 2 inch have been fabricated by utilizing this method. Microstructural studies reveals two distinct regions in these levitators due to different growth mechanism along a/b and c axis. Some initial results on the mass production of these levitators are also reported.
Development of fast two-dimensional standing wave microscopy using acousto-optic deflectors (2008)

A novel scheme for two-dimensional (2D) standing wave fluorescence microscopy (SWFM) using acousto-optic deflectors (AODs) is proposed. Two laser beams were coupled into an inverted microscope and focused at the back focal plane of the objective lens. The position of each of two beams at the back focal plane was controlled by a pair of AODs. This resulted in two collimated beams that interfered in the focal plane, creating a lateral periodic excitation pattern with variable spacing and orientation. The phase of the standing wave pattern was controlled by phase delay between two RF sinusoidal signals driving the AODs. Nine SW patterns of three different orientations about the optical axis and three different phases were generated. The excitation of the specimen using these patterns will result in a SWFM image with enhanced 2D lateral resolution with a nearly isotropic effective point-spread function. Rotation of the SW pattern relative to specimen and varying the SW phase do not involve any mechanical movements and are only limited by the time required for the acoustic wave to fill the aperture of AOD. The resulting total acquisition time can be as short as 100 µs and is only further limited by speed and sensitivity of the employed CCD camera. Therefore, this 2D SWFM can provide a real time imaging of subresolution processes such as docking and fusion of synaptic vesicles. In addition, the combination of 2D SWFM with variable angle total internal reflection (TIR) can extend this scheme to fast microscopy with enhanced three-dimensional (3D) resolution.
A new and unexpected aminoisoquinoline formed under bischler‐napieralski reaction conditions provides for A new synthesis of 3‐aminoisoquinolines (1990)

Abstract Treatment of an amide, 1 , of a substituted 2‐phenethylamine using Bischler‐Napieralski reaction conditions with acetonitrile as a solvent, gave the desired dihydroisoquinoline 2 as well as an unexpected 3‐aminoisoquinoline product 3 . The applicability of this finding as a method of synthesizing 3‐aminoisoquinoline derivatives was examined.
Film Extrusion of <em>Crambe abyssinica</em>/Wheat Gluten Blends (2017)

Crambe abyssinica is a plant with potential for use in industrial (non-food) plant oil production. The side stream from this oil production is a high-protein crambe meal that has limited value, as it is not fit for food or feed use. However, it contains proteins that could potentially make it a suitable raw material for higher-value products. The purpose of this study was to find methods of making this side stream into extruded films, showing that products with a higher value can be produced. The study mainly considered the development of material compositions and methods of preparing and extruding the material. Wheat gluten was added as a supportive protein matrix material, together with glycerol as a plasticizer and urea as a denaturant. The extrudate was evaluated with respect to mechanical (tensile testing) and oxygen barrier properties, and the extrudate structure was revealed visually and by scanning electron microscopy. A denser, more homogeneous material had a lower oxygen transmission rate, higher strength, and higher extensibility. The most homogeneous films were made at an extruder die temperature of 125-130 °C. It is shown here that a film can be extruded with promising mechanical and oxygen barrier properties, the latter especially after a final compression molding step.
Correction: Author Correction: A simple and versatile design concept for fluorophore derivatives with intramolecular photostabilization (2018)

This corrects the article DOI: 10.1038/ncomms10144.
High Fidelity Patient-Derived Xenografts for Accelerating Prostate Cancer Discovery and Drug Development (2013)

Standardized and reproducible preclinical models that recapitulate the dynamics of prostate cancer are urgently needed. We established a bank of transplantable patient-derived prostate cancer xenografts that capture the biologic and molecular heterogeneity currently confounding prognostication and therapy development. Xenografts preserved the histopathology, genome architecture, and global gene expression of donor tumors. Moreover, their aggressiveness matched patient observations, and their response to androgen withdrawal correlated with tumor subtype. The panel includes the first xenografts generated from needle biopsy tissue obtained at diagnosis. This advance was exploited to generate independent xenografts from different sites of a primary site, enabling functional dissection of tumor heterogeneity. Prolonged exposure of adenocarcinoma xenografts to androgen withdrawal led to castration-resistant prostate cancer, including the first-in-field model of complete transdifferentiation into lethal neuroendocrine prostate cancer. Further analysis of this model supports the hypothesis that neuroendocrine prostate cancer can evolve directly from adenocarcinoma via an adaptive response and yielded a set of genes potentially involved in neuroendocrine transdifferentiation. We predict that these next-generation models will be transformative for advancing mechanistic understanding of disease progression, response to therapy, and personalized oncology.
Segment Distribution of the Micellar Brushes of Poly(ethylene oxide) via Small-Angle Neutron Scattering (2000)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionSegment Distribution of the Micellar Brushes of Poly(ethylene oxide) via Small-Angle Neutron ScatteringYou-Yeon Won, H. Ted Davis, Frank S. Bates, M. Agamalian, and G. D. WignallCite this: J. Phys. Chem. B 2000, 104, 38, 9054Publication Date (Web):August 30, 2000Publication History Published online30 August 2000Published inissue 1 September 2000https://pubs.acs.org/doi/10.1021/jp002934fhttps://doi.org/10.1021/jp002934fcorrectionACS PublicationsCopyright © 2000 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views330Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (5 KB) Get e-Alertsclose Get e-Alerts
Phylogenetic distribution in the genus Mus of t-complex-specific DNA and protein markers: inferences on the origin of t-haplotypes. (1988)

We have examined the phylogenetic distribution of two t-specific markers among representatives of various taxa belonging to the genus Mus. The centromeric TCP-1a marker (a testicular protein variant specific for all t-haplotypes so far studied) has also been apparently detected in several non-t representatives of the Mus IVA, Mus IVB, and probably M. cervicolor species. By contrast, a t-specific restriction-fragment-length polymorphism allele (RFLP) of the telomeric alpha-globin pseudogene DNA marker alpha-psi-4 was found only in animals belonging to the M. musculus-complex species either bearing genuine t-haplotypes or, like the M. m. bactrianus specimen studied here, likely to do so. This t-specific alpha-psi-4 RFLP allele was found to be as divergent from the RFLP alleles of the latter, non-t, taxonomical groups as it is from Mus 4A, Mus 4B, or M. spretus ones. These results suggest the presence of t-haplotypes and of t-specific markers in populations other than those belonging to the M. m. domesticus and M. m. musculus subspecies, implying a possible origin for t-haplotypes prior to the radiation of the most recent offshoot of the Mus genus (i.e., the spretus/domesticus divergence), some 1-3 Myr ago.
A search for $t\bar{t}$ resonances with the ATLAS detector in 2.05 fb−1 of proton-proton collisions at $\sqrt{s} = 7~\mathrm{TeV}$ (2012)

A search for top quark pair resonances in final states containing at least one electron or muon has been performed with the ATLAS experiment at the CERN Large Hadron Collider. The search uses a data sample corresponding to an integrated luminosity of 2.05 fb<sup>-1</sup>, which was recorded in 2011 at a proton-proton centre-of-mass energy of 7 TeV. No evidence for a resonance is found and limits are set on the production cross-section times branching ratio to [Formula: see text] for narrow and wide resonances. For narrow <i>Z</i>' bosons, the observed 95 % Bayesian credibility level limits range from 9.3 pb to 0.95 pb for masses in the range of <i>m</i><sub><i>Z</i>'</sub>=500 GeV to <i>m</i><sub><i>Z</i>'</sub>=1300 GeV. The corresponding excluded mass region for a leptophobic topcolour <i>Z</i>' boson (Kaluza-Klein gluon excitation in the Randall-Sundrum model) is <i>m</i><sub><i>Z</i>'</sub><880 GeV ([Formula: see text]).
Design and implementation of adaptive filters (2003)

The adaptive filter design and implementation (AFDI) interactive software package is a set of programs for design, evaluation, and implementation of adaptive filters. AFDI includes adaptive filters, signal generation, data acquisition, file management, signal analysis, and TMS32010 assembly code generation facilities. AFDI allows repeated evaluation of the performance of a filter to select optimum structure, algorithm, and parameter values for particular applications. Many routines that provide rudimentary capabilities for constructing adaptive filters are included.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Figure 2 from Identification of Anti-CA125 Antibody Responses in Ovarian Cancer Patients by a Novel Deep Sequence–Coupled Biopanning Platform (2023)

&lt;p&gt;Supplemental Figure 2. OvCa patient survival based on CA125, anti-CA125, and anti-DISGTNTSRA status at time of diagnosis.&lt;/p&gt;