gebhart/patrepeval huggingface dataset:
High-Speed Power System Transient Stability Simulation Using Highly Dedicated Hardware (2013)

This paper presents a fully analog demonstrator based on power system emulation for high-speed power system stability analysis. A benchmark using a fixed two-machine topology has been implemented. The characteristics of the emulated components (i.e., generators and transmission lines) are reprogrammable and short circuits can be emulated at different distances from the generator. This first realization is limited to transient stability analysis, as the main focus during design was put on computation speed. Indeed, the emulated phenomena are 10 000 times faster than real time. Moreover the authors aim to emphasize that such highly dedicated computation architectures are not only competitive in terms of speed, but also in terms of modularity.
MISE (2017)

In-network services, usually implemented through middle-boxes, play a key role in today's Internet. They enhance end-to-end connections with the ability to provide content optimization, performance enhancement, privacy protection, etc. Multiple in-network services are often combined together to form a so-called Service Function Chain (SFC). Most SFC steering techniques are effective only when there is full visibility and/or control of the underlying network infrastructure. However, when multiple independent parties are involved, the chain building process may be inefficient.
The Non-lysosomal β-Glucosidase GBA2 Is a Non-integral Membrane-associated Protein at the Endoplasmic Reticulum (ER) and Golgi (2012)

GBA1 and GBA2 are both β-glucosidases, which cleave glucosylceramide (GlcCer) to glucose and ceramide. GlcCer is a main precursor for higher order glycosphingolipids but might also serve as intracellular messenger. Mutations in the lysosomal GBA1 underlie Gaucher disease, the most common lysosomal storage disease in humans. Knocking out the non-lysosomal GBA2 in mice results in accumulation of GlcCer outside the lysosomes in various tissues (e.g. testis and liver) and impairs sperm development and liver regeneration. However, the underlying mechanisms are not well understood. To reveal the physiological function of GBA2 and, thereby, of the non-lysosomal GlcCer pool, it is important to characterize the localization of GBA2 and its activity in different tissues. Thus, we generated GBA2-specific antibodies and developed an assay that discriminates between GBA1 and GBA2 without the use of detergent. We show that GBA2 is not, as previously thought, an integral membrane protein but rather a cytosolic protein that tightly associates with cellular membranes. The interaction with the membrane, in particular with phospholipids, is important for its activity. GBA2 is localized at the ER and Golgi, which puts GBA2 in a key position for a lysosome-independent route of GlcCer-dependent signaling. Furthermore, our results suggest that GBA2 might affect the phenotype of Gaucher disease, because GBA2 activity is reduced in Gba1 knock-out fibroblasts and fibroblasts from a Gaucher patient. Our results provide the basis to understand the mechanism for GBA2 function in vivo and might help to unravel the role of GBA2 during pathogenesis of Gaucher disease.
Should it Stay or Should it Go? Thinking Critically About Posterior Tibial Tendon Excision in Flatfoot Correction (2019)

Stage II adult acquired flatfoot deformity is characterized by painful, progressive collapse long thought to be driven by posterior tibialis tendon (PTT) deficiency or insufficiency. In this article, we discuss the history of our understanding the role of the PTT in the development of adult acquired flatfoot deformity, and considerations in tendon excision in flatfoot correction. We argue that routine excision of the PTT should be rethought and instead the tendon should be critically assessed in each case and debridement with repair should be attempted when appropriate. Technique for flexor digitorum longus transfer is detailed as well as preoperative evaluation, imaging, nonoperative treatment, and adjuvants including biologics.
Bounds and dynamics for empirical game theoretic analysis (2019)

Abstract This paper provides several theoretical results for empirical game theory. Specifically, we introduce bounds for empirical game theoretical analysis of complex multi-agent interactions. In doing so we provide insights in the empirical meta game showing that a Nash equilibrium of the estimated meta-game is an approximate Nash equilibrium of the true underlying meta-game. We investigate and show how many data samples are required to obtain a close enough approximation of the underlying game. Additionally, we extend the evolutionary dynamics analysis of meta-games using heuristic payoff tables (HPTs) to asymmetric games. The state-of-the-art has only considered evolutionary dynamics of symmetric HPTs in which agents have access to the same strategy sets and the payoff structure is symmetric, implying that agents are interchangeable. Finally, we carry out an empirical illustration of the generalised method in several domains, illustrating the theory and evolutionary dynamics of several versions of the AlphaGo algorithm (symmetric), the dynamics of the Colonel Blotto game played by human players on Facebook (symmetric), the dynamics of several teams of players in the capture the flag game (symmetric), and an example of a meta-game in Leduc Poker (asymmetric), generated by the policy-space response oracle multi-agent learning algorithm.
Polariton enhanced infrared reflection of epitaxial graphene (2011)

We show SiC substrate phonon-induced surface plasmon polariton (SPP) formation in epitaxial graphene grown on 4H–SiC, in SiC’s restrahlen band (8–10 μm). By fitting measurement to theory, we extract thickness, momentum scattering time (τ), sheet carrier density (ns), and estimate carrier mobility. By showing that τ∝1ns, we argue that scattering is dominated by short-range interactions at the SiC/graphene interface. SPP formation finds application in nanophotonic devices for optical computing because of graphene’s unique plasmonic properties.
The use of a stable internal mass standard for accurate mass measurements of oligonucleotide fragment ions using electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry with infrared multiphoton dissociation (1998)

In this work we demonstrate the use of peptide as a stable internal mass standard to obtain accurate mass measurements of infrared multiphoton dissociation (IRMPD) generated phosphorothioate oligonucleotide fragment ions. Because oligonucleotides are more readily dissociated in the gas phase by IRMPD than are proteins or peptides, the duration and power of the IRMPD event can be set above the oligonucleotide dissociation threshold without inducing fragmentation of the internal peptide standard. This concept is illustrated with electrospray ionization fourier transform ion cyclotron resonance IRMPD of a 20-mer phosphorothioate oligonucleotide in the presence of a small amount of insulin a-chain. Using several isotope peaks from multiple charge states of the a-chain as an internal mass standard provides low-ppm mass measurement errors for the IRMPD generated phosphorothioate oligonucleotide fragment ions. In addition to simplifying the assignment of fragment ions generated from IRMPD of oligonucleotides, this method should be directly applicable to the characterization of DNA and RNA adducts and other base modifications, and may facilitate elemental composition determinations of adducts and base modifications from the resulting mass measurements. © 1998 John Wiley & Sons, Ltd.
Knochen-Biopsiesysteme: mechanische Eigenschaften, Nadeldesign und Probenqualität (2011)

Bone biopsy needles vary significantly in performance. Needle design has an important influence on mechanical properties, handling and specimen quality. Detailed knowledge of those parameters would improve selecting the appropriate bone biopsy needle.
Lenalidomide and Arsenic Trioxide Have Independent Non-Interfering Effects When Used in Combination on Myeloma Cell Lines in &lt;i&gt;Vitro&lt;/i&gt; (2013)

Multiple myeloma (MM) is a plasma cell neoplasm characterized for its fast evolution and for being practically incurable, presenting a strong need for the development of therapies to target it. Among those under study are lenalidomide and arsenic trioxide (ATO) which show individual clinical promise, although never tested together. However, the combination of ATO with thalidomide, another immunomodulatory drug and lenalidomide’s structural albeit less potent analog, have been tried clinically with some success. Therefore, we investigated the effect the combination of lenalidomide and ATO have on the MM-derived U266 and RPMI 8226 cell lines. We observed that both compounds have separate, non-interfering, anti-myeloma mechanisms with ATO demonstrating strong cytotoxic effects while lenalidomide’s role remains cytostatic and immunomodulatory. However, ATO decreases cdc25c, which helps sensitize cells to lenalidomide effects enhancing the efficacy of their interaction. Mechanistically the combination of these two agents decreased the expression of MDM2, without affecting p53 activation or its expression. Therefore, this short study provides the foundation to continue mechanistic studies of the combination of lenalidomide and ATO as a foundation for future clinical application.
Context-aware service composition in cyber physical human system for transportation safety (2013)

The paper addresses the problem of increasing transportation safety due to usage of new possibilities provided by modern technologies. The proposed approach extends such systems as ERA-GLONASS and eCall via service network composition enabling not only transmitting additional information but also information fusion for defining required emergency means as well as planning for a whole emergency response operation. The main idea of the approach is to model the cyber physical human system components by sets of services representing them. The services are provided with the capability of self-contextualisation to autonomously adapt their behaviours to the context of the car-driver system. The approach is illustrated via an accident emergency situation response scenario.
Repeater insertion in tree structured inductive interconnect (1999)

The effects of inductance on repeater insertion in RLC trees is the focus of the paper. An algorithm is introduced to insert and size repeaters within an RLC tree to optimize a variety of possible cost functions such as minimizing the maximum path delay, the skew between branches, or a combination of area, power, and delay. The algorithm has a complexity proportional to the square of the number of possible repeater positions, permitting a repeater solution to be chosen that is close to the global minimum. The repeater insertion algorithm is used to insert repeaters within several copper based interconnect trees to minimize the maximum path delay based on both an RC model and an RLC model. The two buffering solutions are compared using the AS/X dynamic circuit simulator. It is shown that as inductance effects increase, the area and power consumed by the inserted repeaters to minimize the path delays of an RLC tree decreases. By including inductance in the repeater insertion methodology, the interconnect is modeled more accurately as compared to an RC model, permitting average savings in area, power, and delay of 40.8%, 15.6%, and 6.7%, respectively, for a variety of copper based interconnect trees from a 0.25 /spl mu/m CMOS technology. The average savings in area, power, and delay increases to 62.2%, 57.2% and 9.4%, respectively, when using five times faster devices with the same interconnect trees.
Darstellung und Reaktionen α‐polychlorierter tertiärer Amine (1969)

Abstract Tert. α‐Polychloramine 3a – j werden durch photochemische Chlorierung von tert. Aminen 1a – h , tert. Formamidchloriden 4a – c und tert. Thioformamiden 5a – b erhalten. N.N ‐Bis‐trichlormethyl‐aniline 3a – b zerfallen bei 160 – 200° in Isocyaniddichloride 2a – b und Tetrachlorkohlenstoff. Die Reaktionen von tert. α‐Polychloraminen mit wasserfreier Ameisensäure und Flußsäure werden beschrieben.
Proteomics Computational Analyses Suggest that the Antennavirus Glycoprotein Complex Includes a Class I Viral Fusion Protein (α-Penetrene) with an Internal Zinc-Binding Domain and a Stable Signal Peptide (2019)

A metatranscriptomic study of RNA viruses in cold-blooded vertebrates identified two related viruses from frogfish (<i>Antennarius striatus</i>) that represent a new genus <i>Antennavirus</i> in the family <i>Arenaviridae</i> (Order: <i>Bunyavirales</i>). Computational analyses were used to identify features common to class I viral fusion proteins (VFPs) in antennavirus glycoproteins, including an N-terminal fusion peptide, two extended alpha-helices, an intrahelical loop, and a carboxyl terminal transmembrane domain. Like mammarenavirus and hartmanivirus glycoproteins, the antennavirus glycoproteins have an intracellular zinc-binding domain and a long virion-associated stable signal peptide (SSP). The glycoproteins of reptarenaviruses are also class I VFPs, but do not contain zinc-binding domains nor do they encode SSPs. Divergent evolution from a common progenitor potentially explains similarities of antennavirus, mammarenavirus, and hartmanivirus glycoproteins, with an ancient recombination event resulting in a divergent reptarenavirus glycoprotein.
Coherent control of a nitrogen-vacancy center spin ensemble with a diamond mechanical resonator (2015)

Coherent control of the nitrogen-vacancy (NV) center in diamond’s triplet spin state has traditionally been accomplished with resonant ac magnetic fields. Here, we show that high-frequency stress resonant with the spin state splitting can also coherently control NV center spins. Because this mechanical drive is parity non-conserving, controlling spins with stress enables direct access to the magnetically forbidden |−1〉↔|+1〉 spin transition. Using a bulk-mode mechanical microresonator fabricated from single-crystal diamond, we apply intense ac stress to the diamond substrate and observe mechanically driven Rabi oscillations between the |−1〉 and |+1〉 states of an NV center spin ensemble. Additionally, we measure the inhomogeneous spin dephasing time (T2*) of the spin ensemble within this {−1,+1} subspace using a mechanical Ramsey sequence and compare it to the dephasing times measured with a magnetic Ramsey sequence for each of the three spin qubit combinations available within the NV center ground state. These results demonstrate coherent control of a spin with a mechanical resonator and could lead to the creation of a phase-sensitive Δ-system inside the NV center ground state with potential applications in quantum optomechanics and metrology.
ChemInform Abstract: Structural Basis of Binding of High‐Affinity Ligands to Protein Kinase C: Prediction of the Binding Modes Through a New Molecular Dynamics Method and Evaluation by Site‐Directed Mutagenesis. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Diffusional Fluorescence Quenching of Aromatic Hydrocarbons (2003)

The quenching of the fluorescence of five aromatic hydrocarbons by three halogenated organics and by molecular oxygen has been measured. Both fluorescence intensity and fluorescence lifetime measurements have been employed to validate results and interpretation; linear Stern-Volmer analyses are shown to apply throughout. The fluorescence quenching rate constant of molecular oxygen for the five aromatic hydrocarbons is essentially equivalent to the diffusion rate constant independent of the fluorophore excitation energy. The halogenated organic-fluorophore rate constants vary by a factor of 965 and are shown to correlate roughly with the energy difference between the quencher and fluorophore excited electronic states in accord with a standard model of quantum two-level mixing. The value of the coupling interaction energy is approximately 2500 cm(-1).
EFFECTS OF AN ANTISENSE OLIGODEOXYNUCLEOTIDE ON BEHAVIOR AND CANNABINOID CB1 RECEPTOR AGONIST-INDUCED HYPOTHERMIA AND ANALGESIA IN THE RAT (1999)

s of the First Congress of the Behavioral Pharmacology Society and the European Behavioural Pharmacology Society: PDF Only
Forming-free resistive switching characteristics in manganese oxide and hafnium oxide devices (2019)

Abstract Resistive switching properties of hafnium oxide and manganese oxide double-layer films sandwiched between Pt bottom electrode and Ag top electrode have been investigated. The devices exhibited bipolar resistive switching. As compared with the devices with hafnium oxide and manganese oxide single layer, the double-layered devices showed better resistive switching behaviors, including forming-free behavior, a high resistance ratio (&gt;10 5–6 ), and good retention properties. The forming-free behavior of the bilayer device is very useful for resistive random access memory applications. The high resistance ratio is beneficial to distinguish the storage information. The formation and disruption of Ag conductive filament in the oxide layers led to the resistance changes.
Identification of a Streptococcus suis 60-kDa heat-shock protein using Western blotting (2006)

This study was initiated to investigate the presence of stress or heat shock proteins in Streptococcus suis. SDS-PAGE and Western blotting using polyclonal and monoclonal antibodies directed against different bacterial heat shock proteins demonstrated cross-reactivity with a protein with an apparent molecular mass of 60 kDa in all S. suis serotypes tested. The 60-kDa cross-reactive protein was present in virulent and avirulent strains of S. suis serotype 2 tested. A rabbit antiserum raised against the 60-kDa S. suis protein recognized the 60-65-kDa heat shock proteins in different Gram-positive and Gram-negative bacteria. Finally, the 60-kDa heat shock protein of S. suis was shown to be mostly secreted into the culture supernatant and, to a lesser extent, cell-associated. Growth under heat stress conditions (42 degrees C) increased the expression of the 60-kDa S. suis protein. This protein is, to our knowledge, the first common antigen found in different serotypes of S. suis.
Compliant Mechanism Road Bicycle Brake: A Rigid-Body Replacement Case Study (2011)

This paper demonstrates rigid-body replacement synthesis in the design a mechanism with known design objectives. The design of high-performance bicycle brakes is complicated by a variety of competing design objectives, including increased performance and low weight. But this challenge also provides a good case study to demonstrate the design of compliant mechanisms to replace traditional rigid-link mechanisms. This paper briefly reviews current road brake designs, demonstrates the use of rigid-body replacement synthesis to design a compliant mechanism, and illustrates the combination of compliant mechanism design tools. The resulting concept was generated from the modified dual-pivot brake design and is a partially compliant mechanism where one pin has the dual role of a joint and a mounting pin. The pseudo-rigid-body model, finite element analysis, and optimization algorithms are used to generate design dimensions, and designs are considered for both titanium and E-glass flexures. The resulting design has the potential of reducing the part count and overall weight while maintaining a performance similar to the benchmark.
Feasibility of the pupillary pain index as a guide for depth of analgesia during opioid-sparing anesthesia with continuous infusion of dexmedetomidine (2023)

Trial.gov registration number: NCT05785273.
COMBINED FORCED CONVECTION AND SURFACE RADIATION IN CONCENTRIC ANNULI (2009)

The effects of surface radiation on the developing laminar forced convection flow of a transparent gas in concentric annuli are numerically investigated under the thermal conditions of inner wall is uniformly heated and the outer wall is adiabatic. To conduct this investigation, four shape factors not available in the literature (between a differential ring on the inner and outer surfaces of annulus and the annular opening at the inlet and the exit end of the annulus) have been derived and validated. The effect of radius ratio on thermal radiation interchange between the two walls of the annuli is presented and discussed. The effects of other controlling parameters on wall temperature and Nusslet number are illustrated. Finally, threshold values of the emissivity at which radiation effects can be neglected are obtained and presented.
Reactivity of nucleoside 5′‐O‐phosphates, ‐phosphorothioates, ‐methanephosphonates, and ‐methanephosphonothioates toward activated xylonucleosides (1999)

Alkylation of ambident thymidine 5′-O-(O-alkyl phosphorothioate) anions by means of 3′-O-sulfonylated xylothymidine occurs at both O- and S-nucleophilic centers, and formation of an internucleotide bond is accompanied by the process of elimination. Lack of chemoselectivity and low yields of products discriminate against such an approach as an effective method of stereocontrolled synthesis of P-chiral oligo(nucleoside phosphorothioate)s. © 1999 John Wiley & Sons, Inc. Heteroatom Chem 10: 91–104, 1999
Column liquid chromatography (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTColumn liquid chromatographyHoward G. Barth, William E. Barber, Charles H. Lochmueller, Ronald E. Majors, and F. E. RegnierCite this: Anal. Chem. 1988, 60, 12, 387–435Publication Date (Print):June 15, 1988Publication History Published online1 May 2002Published inissue 15 June 1988https://pubs.acs.org/doi/10.1021/ac00163a025https://doi.org/10.1021/ac00163a025research-articleACS PublicationsRequest reuse permissionsArticle Views927Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
EC144 Is a Potent Inhibitor of the Heat Shock Protein 90 (2012)

Alkyne 40, 5-(2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methylpent-4-yn-2-ol (EC144), is a second generation inhibitor of heat shock protein 90 (Hsp90) and is substantially more potent in vitro and in vivo than the first generation inhibitor 14 (BIIB021) that completed phase II clinical trials. Alkyne 40 is more potent than 14 in an Hsp90α binding assay (IC(50) = 1.1 vs 5.1 nM) as well as in its ability to degrade Her-2 in MCF-7 cells (EC(50) = 14 vs 38 nM). In a mouse model of gastric tumors (N87), 40 stops tumor growth at 5 mg/kg and causes partial tumor regressions at 10 mg/kg (po, qd × 5). Under the same conditions, 14 stops tumor growth only at 120 mg/kg, and does not induce partial regressions. Thus, alkyne 40 is approximately 20-fold more efficacious than 14 in mice.