gebhart/patrepeval huggingface dataset:
Neurophysiological correlates of dissociative symptoms (2012)

HRV, EEG and (functional) MRI are sensitive methods to detect physiological changes related to dissociation and dissociative disorders such as FNSS, and can possibly provide more information about their aetiology. The use of such measures could eventually provide biomarkers for earlier identification of patients at risk and appropriate treatment of dissociative conditions.
Firstin vivomagnetic particle imaging of lung perfusion in rats (2017)

Pulmonary embolism (PE), along with the closely related condition of deep vein thrombosis, affect an estimated 600 000 patients in the US per year. Untreated, PE carries a mortality rate of 30%. Because many patients experience mild or non-specific symptoms, imaging studies are necessary for definitive diagnosis of PE. Iodinated CT pulmonary angiography is recommended for most patients, while nuclear medicine-based ventilation/perfusion (V/Q) scans are reserved for patients in whom the use of iodine is contraindicated. Magnetic particle imaging (MPI) is an emerging tracer imaging modality with high image contrast (no tissue background signal) and sensitivity to superparamagnetic iron oxide (SPIO) tracer. Importantly, unlike CT or nuclear medicine, MPI uses no ionizing radiation. Further, MPI is not derived from magnetic resonance imaging (MRI); MPI directly images SPIO tracers via their strong electronic magnetization, enabling deep imaging of anatomy including within the lungs, which is very challenging with MRI. Here, the first high-contrast in vivo MPI lung perfusion images of rats are shown using a novel lung perfusion agent, MAA-SPIOs.
A novel cost-sensitive framework for customer churn predictive modeling (2015)

Customer churn predictive modeling deals with predicting the probability of a customer defecting using historical, behavioral and socio-economical information. This tool is of great benefit to subscription based companies allowing them to maximize the results of retention campaigns. The problem of churn predictive modeling has been widely studied by the data mining and machine learning communities. It is usually tackled by using classification algorithms in order to learn the different patterns of both the churners and non-churners. Nevertheless, current state-of-the-art classification algorithms are not well aligned with commercial goals, in the sense that, the models miss to include the real financial costs and benefits during the training and evaluation phases. In the case of churn, evaluating a model based on a traditional measure such as accuracy or predictive power, does not yield to the best results when measured by the actual financial cost, ie. investment per subscriber on a loyalty campaign and the financial impact of failing to detect a real churner versus wrongly predicting a non-churner as a churner. In this paper, we present a new cost-sensitive framework for customer churn predictive modeling. First we propose a new financial based measure for evaluating the effectiveness of a churn campaign taking into account the available portfolio of offers, their individual financial cost and probability of offer acceptance depending on the customer profile. Then, using a real-world churn dataset we compare different cost-insensitive and cost-sensitive classification algorithms and measure their effectiveness based on their predictive power and also the cost optimization. The results show that using a cost-sensitive approach yields to an increase in cost savings of up to 26.4 %.
Pacing After Shocks Stronger Than the Upper Limit of Vulnerability (2000)

At least 3 cycles with short CIs are necessary for VF induction after aULV shocks. Cycles S3-S4 may create the substrate for cycle S5 to initiate VF.
Relation between Tibial Drawer Force, Muscle Tension, and Body Posture in Leg Press Exercises (2010)

前十字靱帯（ACL）再建術術後の大腿四頭筋筋力訓練の一つにレッグプレス運動がある．本研究では，レッグプレス運 動において，姿勢の違いがACL にかかる負荷である脛骨引き出し力や筋張力に与える影響について考察した．矢状面から動作計測を行い，下肢関節角度と足部に作用する反力から筋骨格モデルを用いて脛骨引き出し力や筋張力を推定した．11 種の姿勢について検討した結果，脛骨へは常に後方引き出し力が作用しACL 再建術術後の大腿四頭筋筋力訓練としてレッグプレス運動は安全であること，体幹を屈曲させることでより大きな後方引き出し力が作用しより安全に行えることが示唆された．
Neurogenesis deep learning: Extending deep networks to accommodate new classes (2017)

Neural machine learning methods, such as deep neural networks (DNN), have achieved remarkable success in a number of complex data processing tasks. These methods have arguably had their strongest impact on tasks such as image and audio processing - data processing domains in which humans have long held clear advantages over conventional algorithms. In contrast to biological neural systems, which are capable of learning continuously, deep artificial networks have a limited ability for incorporating new information in an already trained network. As a result, methods for continuous learning are potentially highly impactful in enabling the application of deep networks to dynamic data sets. Here, inspired by the process of adult neurogenesis in the hippocampus, we explore the potential for adding new neurons to deep layers of artificial neural networks in order to facilitate their acquisition of novel information while preserving previously trained data representations. Our results on the MNIST handwritten digit dataset and the NIST SD 19 dataset, which includes lower and upper case letters and digits, demonstrate that neurogenesis is well suited for addressing the stability-plasticity dilemma that has long challenged adaptive machine learning algorithms.
Understanding mNP hyperthermia for cancer treatment at the cellular scale (2013)

The use of magnetic nanoparticles (mNP's) to induce local hyperthermia has been emerging in recent years as a promising cancer therapy, in both a stand-alone and combination treatment setting. Studies have shown that cancer cells associate with, internalize, and aggregate mNP's more preferentially than normal cells. Once the mNP's are delivered inside the cells, a low frequency (30 kHz-300 kHz) alternating electromagnetic field is used to activate the mNP's. The nanoparticles absorb the applied field and provide localized heat generation at nano-micron scales. It has been shown experimentally that mNP's exhibit collective behavior when in close proximity. Although most prevailing mNP heating models assume there is no magnetic interaction between particles, our data suggests that magnetic interaction effects due to mNP aggregation are often significant; In the case of multi-crystal core particles, interaction is guaranteed. To understand the physical phenomena responsible for this effect, we modeled electromagnetic coupling between mNP's in detail. The computational results are validated using data from the literature as well as measurements obtained in our lab. The computational model presented here is based on a method of moments technique and is used to calculate magnetic field distributions on the nanometer scale, both inside and outside the mNP.
Light Propagation in 3-D Photonic Crystals (2011)

We introduce recent progress on the control of light propagation in three-dimensional (3-D) photonic crystals. We demonstrate 3-D guiding within photonic crystal-embedded waveguides. A novel controlling approach using the surface of crystals is also discussed.
Search for scalar resonances decaying into μ+μ− in events with and without b-tagged jets produced in proton-proton collisions at $$ \sqrt{s}=13 $$ TeV with the ATLAS detector (2019)

A bstract A search for a narrow scalar resonance decaying into an opposite-sign muon pair produced in events with and without b -tagged jets is presented in this paper. The search uses 36.1 fb −1 of $$ \sqrt{s}=13 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>13</mml:mn> </mml:math> TeV proton-proton collision data recorded by the ATLAS experiment at the LHC. No significant excess of events above the expected Standard Model background is observed in the investigated mass range of 0.2 to 1.0 TeV. The observed upper limits at 95% confidence level on the cross section times branching ratio for b -quark associated production and gluon-gluon fusion are between 1.9 and 41 fb and 1.6 and 44 fb respectively, which is consistent with expectations.
Comparable Antigenicity and Immunogenicity of Oligomeric Forms of a Novel, Acute HIV-1 Subtype C gp145 Envelope for Use in Preclinical and Clinical Vaccine Research (2015)

At present, the product pipeline for HIV vaccines is insufficient and is limited by inadequate capacity to produce large quantities of vaccine to standards required for human clinical trials. Such products are required to evaluate critical questions of vaccine formulation, route, dosing, and schedule, as well as to establish vaccine efficacy. The gp145 Env protein presented in this study forms physical trimers, binds to many of the well-characterized broad neutralizing MAbs that target conserved Env epitopes, and induce cross-subtype neutralizing antibodies as measured in both cell line and primary cell assays. This subtype C Env gp145 protein is currently undergoing good manufacturing practice production for use as a reagent for preclinical studies and for human clinical research. This product will serve as a reagent for comparative studies and may represent a next-generation candidate HIV immunogen.
Neuronal tau pathology worsens late-phase white matter degeneration after traumatic brain injury in transgenic mice (2023)

Traumatic brain injury (TBI) causes diffuse axonal injury which can produce chronic white matter pathology and subsequent post-traumatic neurodegeneration with poor patient outcomes. Tau modulates axon cytoskeletal functions and undergoes phosphorylation and mis-localization in neurodegenerative disorders. The effects of tau pathology on neurodegeneration after TBI are unclear. We used mice with neuronal expression of human mutant tau to examine effects of pathological tau on white matter pathology after TBI. Adult male and female hTau.P301S (Tg2541) transgenic and wild-type (Wt) mice received either moderate single TBI (s-TBI) or repetitive mild TBI (r-mTBI; once daily × 5), or sham procedures. Acutely, s-TBI produced more extensive axon damage in the corpus callosum (CC) as compared to r-mTBI. After s-TBI, significant CC thinning was present at 6 weeks and 4 months post-injury in Wt and transgenic mice, with homozygous tau expression producing additional pathology of late demyelination. In contrast, r-mTBI did not produce significant CC thinning except at the chronic time point of 4 months in homozygous mice, which exhibited significant CC atrophy (- 29.7%) with increased microgliosis. Serum neurofilament light quantification detected traumatic axonal injury at 1 day post-TBI in Wt and homozygous mice. At 4 months, high tau and neurofilament in homozygous mice implicated tau in chronic axon pathology. These findings did not have sex differences detected. Conclusions: Neuronal tau pathology differentially exacerbated CC pathology based on injury severity and chronicity. Ongoing CC atrophy from s-TBI became accompanied by late demyelination. Pathological tau significantly worsened CC atrophy during the chronic phase after r-mTBI.
Cloning of Cutinase Transcription Factor 1, a Transactivating Protein Containing Cys6Zn2 Binuclear Cluster DNA-binding Motif (1997)

Hydroxy fatty acids from plant cutin were shown previously to induce the expression of the cutinase gene via a palindromic sequence located at -159 base pairs of the cutinase gene in Fusarium solani f. sp. pisi (Nectria hematococca mating type VI). Of the two overlapping palindromes in this sequence, palindrome 2 was found to be essential for the inducibility of cutinase by hydroxy fatty acids. Screening of a phage expression library with the concatenated palindrome 2 as probe detected a distinct cDNA clone encoding a polypeptide designated cutinase transcription factor 1alpha (CTF1alpha) with a calculated molecular weight of 101,109. This protein contains a Cys6Zn2 binuclear cluster motif sharing homology to the Cys6Zn2 binuclear cluster DNA-binding domains of transcription factors from Saccharomyces cerevisiae, S. carlsbergensis, Kluyveromyces lactis, Neurospora crassa, Aspergillus nidulans, and A. flavus. CTF1alpha, expressed in Escherichia coli, showed specific binding to the palindrome 2 DNA fragment but not to palindrome 1 or mutant palindrome 2 DNA fragments, suggesting specific binding of CTF1alpha to palindrome 2. When CTF1alpha was expressed as a fusion protein with the nuclear localization sequence of SV40 in yeast, it transactivated the native cutinase promoter fused to the chloramphenicol acetyl transferase (cat) gene. Mutation of palindrome 2 but not palindrome 1 abolished this transactivation. Thus, CTF1alpha positively acts in vivo by binding selectively to palindrome 2 of the cutinase gene promoter.
Seven-co-ordinate complexes of iron(III) (1966)

S. M. Nelson, P. Bryan and D. H. Busch, Chem. Commun. (London), 1966, 641 DOI: 10.1039/C19660000641
Rising Academic Contributions to Drug Development: Evidence of Vigor or Trauma? (2020)

We analyzed therapeutic areas most commonly targeted by academia since 2001, finding a domination of certain oncology and infectious diseases. These findings raise important questions about whether this trend reflects an expanded opportunity arising from academic research or a troubling sign of an industry struggling with the challenges of innovation.
Multimodality Imaging of Ethiodized Oil–loaded Radiopaque Microspheres during Transarterial Embolization of Rabbits with VX2 Liver Tumors (2015)

Purpose To assess the visibility of radiopaque microspheres during transarterial embolization (TAE) in the VX2 rabbit liver tumor model by using multimodality imaging, including single-snapshot radiography, cone-beam computed tomography (CT), multidetector CT, and micro-CT. Materials and Methods The study was approved by the institutional animal care and use committee. Fifteen VX2-tumor-bearing rabbits were assigned to three groups depending on the type of embolic agent injected: 70-150-μm radiopaque microspheres in saline (radiopaque microsphere group), 70-150-μm radiopaque microspheres in contrast material (radiopaque microsphere plus contrast material group), and 70-150-μm radiolucent microspheres in contrast material (nonradiopaque microsphere plus contrast material group). Rabbits were imaged with single-snapshot radiography, cone-beam CT, and multidetector CT. Three to 5 weeks after sacrifice, excised livers were imaged with micro-CT and histologic analysis was performed. The visibility of the embolic agent was assessed with all modalities before and after embolization by using a qualitative three-point scale score reading study and a quantitative assessment of the signal-to-noise ratio (SNR) change in various regions of interest, including the tumor and its feeding arteries. The Kruskal-Wallis test was used to compare the rabbit characteristics across groups, and the Wilcoxon signed rank test was used to compare SNR measurements before and after embolization. Results Radiopaque microspheres were qualitatively visualized within tumor feeding arteries and targeted tissue with all imaging modalities (P < .05), and their presence was confirmed with histologic examination. SNRs of radiopaque microsphere deposition increased after TAE on multidetector CT, cone-beam CT, and micro-CT images (P < .05). Similar results were obtained when contrast material was added to radiopaque microspheres, except for additional image attenuation due to tumor enhancement. For the group with nonradiopaque microspheres and contrast material, retained tumoral contrast remained qualitatively visible with all modalities except for micro-CT, which demonstrated soluble contrast material washout over time. Conclusion Radiopaque microspheres were visible with all imaging modalities and helped increase conspicuity of the tumor as well as its feeding arteries after TAE in a rabbit VX2 liver tumor model. (©) RSNA, 2015.
Iterated risk measures for risk-sensitive Markov decision processes with discounted cost (2012)

We demonstrate a limitation of discounted expected utility, a standard approach for representing the preference to risk when future cost is discounted. Specifically, we provide an example of the preference of a decision maker that appears to be rational but cannot be represented with any discounted expected utility. A straightforward modification to discounted expected utility leads to inconsistent decision making over time. We will show that an iterated risk measure can represent the preference that cannot be represented by any discounted expected utility and that the decisions based on the iterated risk measure are consistent over time.
Magnetic Actuator for a Capsule Endoscope Navigation System (2007)

The authors propose a magnetic actuator for use as a navigation system for capsule endoscopes. The actuator is composed of a capsule dummy, a permanent magnet inside the capsule, and an external spiral structure. The device rotates and propels wirelessly when exposed to an external rotational magnetic field. In this study we measured the effect of the spiral shape on the velocity and thrust force properties. According to our experimental results, the actuator obtained a maximum velocity and thrust force when the spiral angle was set at 45 degrees, the number of spirals was set at 4, and the spiral-height was set at 1-mmf. We also conducted a motion test in the large intestine of a pig placed on a 30 degrees slope. The actuator passed through a 700 mm length of the intestine in about 300 s. The device also managed to travel up and down the 30 degrees slope with no difficulty whatsoever. Our results demonstrate the great potential of this actuator for use as a navigation system for capsule endoscopes.
Home oxygen therapy after preterm birth in Western Australia (2004)

Our home oxygen programme, based on an air test predischarge and a sleep study prediscontinuation of nocturnal oxygen, facilitates early discharge home. Our data suggest that over the last decade, bronchopulmonary dysplasia is associated with less impairment in lung function. Further evidence from randomized clinical trials is required to determine optimal target range for oxygen saturation in preterm infants.
Efficient block-wise algorithm for compressive holography (2017)

Compressive holography is a relatively time-consuming image estimation in convex optimized problem. We propose an efficient block-wise algorithm to limit the searching space and reduce the calculation time while keeping the reconstruction quality. The effective anti-aliasing boundary of the sub-hologram is located to determine the block size for compressive reconstruction in the total-variation two-step iterative shrinkage/thresholding algorithm. Padded sub-holograms could be reconstructed in parallel by using multi-core processors. Compared with the traditional compressive holography, the block-wise algorithm could take approximately 1/50 of the reconstruction time and achieve an improved reconstruction quality.
Effects of Team Identification on Social and Emotional Adjustment in Higher Education (2015)

Students who highly identify with a team are likely to share a personal self-concept with larger groups in higher education. The improved self-worth is positively associated with the adjustment to college life, and is considered one of the significant predictors to achieve students’ educational goals. However, little research has been conducted to scrutinize the effects of team identification on school adjustment. The purpose of this study, therefore, was to examine direct and indirect relationships among team identification, personal self-esteem, and school adjustment. A total of 254 undergraduate students at a FBS institution in the southeastern region of the United States participated in the study. The results revealed that the higher team identification students possess, the higher personal worth they feel. In addition, team identification and personal self-esteem led to social adjustment while personal self-esteem and social adjustment had a positive impact on emotional adjustment. By understanding team identification as an important academic facilitator, administrators in both the academic and athletic fields can develop the most appropriate environment for students to enhance their adjustment to college life.
Supplementary Figure 1 from Polycomb CBX7 Promotes Initiation of Heritable Repression of Genes Frequently Silenced with Cancer-Specific DNA Hypermethylation (2023)

Supplementary Figure 1 from Polycomb CBX7 Promotes Initiation of Heritable Repression of Genes Frequently Silenced with Cancer-Specific DNA Hypermethylation
Modeling 2D speckle images accounting for 3D strain effects (2002)

Strain imaging can derive clinically important information regarding tissue elasticity. In relatively incompressible materials (such as tissue), a strain in one direction is accompanied by strain of opposite polarity in one or more orthogonal directions. When a regular ultrasound array - long in the azimuth and narrow in elevation - is pressed into soft tissue one expects the primary Poisson ratio related strain to be in the elevation direction. One objective is to determine whether the resultant 'y' strained image is distinguishable from the unstrained case. A second objective is to compare the degree of decorrelation due to elevation strain with that due to small, practically unavoidable, elevational translational offsets. Hence, it is necessary to model full 3D strain effects on speckle. Our conclusion from initial analysis of the impact of elevational strain on 2D speckle patterns is that the associated decorrelation is very small. Consequently, any small elevational translation that occurs during the strain application process will have a dominant effect on the net 2D image decorrelation.
Host-Specific Response to HCV Infection in the Chimeric SCID-beige/Alb-uPA Mouse Model: Role of the Innate Antiviral Immune Response (2006)

The severe combined immunodeficiency disorder (SCID)-beige/albumin (Alb)-urokinase plasminogen activator (uPA) mouse containing a human-mouse chimeric liver is currently the only small animal model capable of supporting hepatitis C virus (HCV) infection. This model was utilized to characterize the host transcriptional response to HCV infection. The purpose of these studies was to investigate the genetic component of the host response to HCV infection and also to distinguish virus-induced gene expression changes from adaptive HCV-specific immune-mediated effects. Gene expression profiles from HCV-infected mice were also compared to those from HCV-infected patients. Analyses of the gene expression data demonstrate that host factors regulate the response to HCV infection, including the nature of the innate antiviral immune response. They also indicate that HCV mediates gene expression changes, including regulation of lipid metabolism genes, which have the potential to be directly cytopathic, indicating that liver pathology may not be exclusively mediated by HCV-specific adaptive immune responses. This effect appears to be inversely related to the activation of the innate antiviral immune response. In summary, the nature of the initial interferon response to HCV infection may determine the extent of viral-mediated effects on host gene expression.