gebhart/patrepeval huggingface dataset:
Hydrogen/Deuterium Exchange Reactions and Transfer Hydrogenations Catalyzed by [C5Me5Rh(olefin)2] Complexes:  Conversion of Alkoxysilanes to Silyl Enolates (1999)

A series of [C5Me5Rh(CH2CHR)2] complexes (1a−e) have been prepared in which the olefin bears a bulky silyl substituent, R = (a) SiMe3, (b) SiMe2OEt, (c) Si(OiPr)3, (d) SiMe(OSiMe3)2, (e) SiPh2OiPr. The solid-state structure of 1c has been determined by X-ray crystallography. When complex 1a is heated (50 °C) in deuterated solvents (C6D6, C6D5CD3, C6D5Cl, or (CD3)2CO), deuterium is incorporated into the olefinic sites. Thermolysis at higher temperatures results in further H/D exchange and deuteration of both the SiMe3 and C5Me5 groups. Heating 1a in C6D6 with added substrates (aniline, MeOtBu, MeOSiMe3, Cp2Fe, cyclopentene, or EtOAc) results in deuteration of these substrates via shuttling of deuterium from C6D6 to the olefinic sites and then into certain sites of the substrates. Thermolysis of 1a in the presence of vinyltrimethylsilane at higher temperatures results in C−Si bond cleavage and generation of a silacyclopentadiene complex (6) whose structure was determined by X-ray analysis. Thermolysis of 1c in C6D6 results in facile H/D exchange and incorporation of deuterium not only into the vinylic positions but also into the methine and methyl groups of the isopropyl substituents. At 90 °C in the presence of CH2CHSi(OiPr)3 a catalytic transfer hydrogenation is observed which converts the vinylsilane to the silyl enolate, Et(iPrO)2SiOCMeCH2. A series of catalytic transfer hydrogenations were carried out in which alkoxysilanes CH2CHSiMe2OR (R = Et, n-Bu, CHMeEt, C2H4tBu, C2H4Ph, CHMePh, CHMeCH2Ph) were converted to the corresponding silyl enolates. Catalytic conversion of the vinylaminosilane CH2CHSiMe2NHC2H4Ph to the silyl enamine EtSiMe2NHC2H2Ph is also reported.
Organic solar cells with very high fill factor and voltage using tetrapropyl‐tetraphenyl‐diindenoperylene as green donor (2010)

Abstract We present 2,3,10,11‐tetrapropyl‐1,4,9,12‐tetraphenyl‐diindeno[1,2,3‐cd:1′,2′,3′‐lm]perylene (P4‐Ph4‐DIP) as new green donor for small molecule organic solar cells (SMOSC). P4‐Ph4‐DIP absorbs in the green spectral range of 490–580 nm and thus is a decisive building block towards broad coverage of the sun spectrum. SMOSC with P4‐Ph4‐DIP as donor and C 60 as blue‐absorbing acceptor display very high fill factors FF &gt; 76% and open circuit voltages of 0.99 V, reaching η = 1.92% for 12 nm P4‐Ph4‐DIP. Current voltage and external quantum efficiency spectra suggest that an exciton diffusion length E D &lt; 20 nm is the main limiting factor. (© 2010 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Prophylaxe der Neugeborenensepsis – frühe Form – durch Streptokokken der Gruppe B. Leitlinie des BVF, BVDfK, der DGGG, DGHM, DGPI, DGPM und GNPI. (S2k-Level, AWMF-Registernummer 024/020, März 2016) (2017)

Die Streptokokken der serologischen Gruppe B (GBS) nach Lancefield (synonym: Streptococcus agalactiae) sind nach wie vor eine der häufigsten Ursachen für schwere Infektionen des Neugeborenen. Dabei wurde in der Literatur zu GBS zwischen einer frühen Form (Early-Onset, innerhalb von 7 Tagen nach der Geburt) und einer späten Form (Late-Onset, 8 Tage bis 3 Monate nach Geburt) unterschieden [1] [2] [3]. Die heutige Definition der Early-Onset Sepsis verwendet allerdings zunehmend eine Grenze von 72 Stunden.
Relationship of hematological variables to learning performance in aged Fischer-344 rats (1995)

The relationship between hematological variables and the ability to perform behaviorally in two learning tests was evaluated in male F344 rats aged 22-24 months. Rats were screened for ability to meet criterion for learning one-way active avoidance in a straight runway task. Rats failing to meet criterion were given no further testing and were assigned to Group 1 (G1). Rats meeting criterion were tested in a 14-unit T-maze (2 days, 10 trials/day). Failure to negotiate the T-maze within 600 s on any three trials resulted in assignment to Group 2 (G2) with no further testing. Rats successfully completing both tasks constituted Group 3 (G3). Trunk blood was collected following behavioral testing and was assayed to determine red blood cell count (RBC), hematocrit (HCT), hemoglobin (HGB), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), white blood cell count (WBC), bands (BND), polymorphs (POLY), lymphocytes (LYM), monocytes (MON), and eosinophils (EOS). The combined G1/G2 group had significantly lower RBC, HCT, HGB, and EOS but significantly higher MCV and MCH than G3 rats. Correlation analysis revealed a positive relationship of group membership (i.e., learning test completion) to RBC, HCT, HGB, and EOS, but a negative correlation of group membership to MCH. No significant correlation emerged between any hematological characteristic and performance in either behavioral task. These results suggest that a simple blood test to determine HCT may be a useful screen for removal of moribund rats from aging studies attempting to control for effects of health on behavioral performance in rodent models.
Direct Detection of miR-122 in Hepatotoxicity Using Dynamic Chemical Labeling Overcomes Stability and isomiR Challenges (2020)

Circulating microRNAs are biomarkers reported to be stable and translational across species. MicroRNA-122 (miR-122) is a hepatocyte-specific microRNA biomarker for drug-induced liver injury (DILI). We developed a single molecule, dynamic chemical labeling (DCL) assay to directly detect miR-122 in blood. The DCL assay specifically measured miR-122 directly from 10 μL of serum or plasma without any extraction steps, with a limit of detection of 1.32 pM that enabled the identification of DILI. Testing of 192 human serum samples showed that DCL accurately identified patients at risk of DILI after acetaminophen overdose (area under ROC curve 0.98 (95% CI; 0.96-1), <i>P</i> < 0.0001). The DCL assay also identified liver injury in rats and dogs. The use of specific captured beads had the additional benefit of stabilizing miR-122 after sample collection, with no signal loss after 14 days at room temperature, in contrast to PCR that showed significant loss of signal. RNA sequencing demonstrated the presence of multiple miR-122 isomiRs in the serum of patients with DILI that were at low concentration or not present in healthy individuals. Sample degradation over time produced more isomiRs, particularly rapidly with DILI. PCR was inaccurate when analyzing miR-122 isomiRs, whereas the DCL assay demonstrated accurate quantification. We conclude that the DCL assay can accurately measure miR-122 to diagnose liver injury in humans and other species and can overcome microRNA stability and isomiR challenges.
Probing Inhibitor-Induced Conformational Changes along the Interface between Tissue Factor and Factor VIIa (2001)

Upon injury of a blood vessel, activated factor VII (FVIIa) forms a high-affinity complex with its allosteric regulator, tissue factor (TF), and initiates blood clotting. Active site-inhibited factor VIIa (FVIIai) binds to TF with even higher affinity. We compared the interactions of FVIIai and FVIIa with soluble TF (sTF). Six residues in sTF were individually selected for mutagenesis and site-directed labeling. The residues are distributed along the extensive binding interface, and were chosen because they are known to interact with the different domains of FVIIa. Fluorescent and spin probes were attached to engineered Cys residues to monitor local changes in hydrophobicity, accessibility, and rigidity in the sTF--FVIIa complex upon occupation of the active site of FVIIa. The results show that inhibition of FVIIa caused the structures around the positions in sTF that interact with the protease domain of FVIIa to become more rigid and less accessible to solvent. Thus, the presence of an active site inhibitor renders the interface in this region less flexible and more compact, whereas the interface between sTF and the light chain of FVIIa is unaffected by active site occupancy.
Array of liquid crystal polymer-based Fabry-Perot resonators for image selection by polarization (2016)

We demonstrate an array of the Fabry-Perot (FP) resonators with a liquid crystal polymer (LCP) layer inside each resonant cavity for image selection by polarization of the incident light. In our approach, the LCP molecules in the array of the FP resonators for different images are photo-aligned in different directions. Under unpolarized light, no image is observed. For the incident light polarized parallel to the photo-alignment direction, only the image corresponding to the polarization state among the recorded images is visible due to the difference in the effective refractive index between different image regions in the array of the FP resonators. Our approach based on anisotropic FP resonators will be useful for the realization of highly efficient and low-cost anti-counterfeiting systems and security labels.
Hydrolysis Resistance of Polylactic Acid Enhanced by Combined Use of Monocarbodiimide and Aromatic Polycarbodiimide (2010)

We have found that combined use of a monocarbodiimide (mono-CDI: bis-2,6-diisopropylphenylcarbodiimide) and an aromatic polycarbodiimide [aro-pCDI: poly(2,4,6-triisopropylphenylene-1,3-diisocyanate)] improves the hydrolysis resistance of polylactic acid (PLA). The hydrolysis time was evaluated by measuring molecular weights of PLA in the PLA compounds including carbodiimides under high temperature and humidity (80°C, 95%RH). When using representative carbodiimides including mono-CDI, aro-pCDI, and an aliphatic polycarbodiimide [ali-pCDI: poly(1,1′-dicyclo hexylmethane-4,4′-diisocyanate)], the hydrolysis time was not satisfactorily enhanced. On the other hand, when using mono-CDI and aro-pCDI at the same time, the hydrolysis time was improved remarkably; the molecular weight of PLA was kept for 600 h, while the original PLA hydrolyzed up in to 50 h. This is mainly due to effective binding of aro-pCDI with hydrolysis products of PLA, which resulted from capturing carboxyl end groups of PLA by mono-CDI.
Joint Communications and Sensing Hybrid Beamforming Design via Deep Unfolding (2023)

Joint communications and sensing (JCAS) is envisioned as a key feature in future wireless communications networks. In massive MIMO-JCAS systems, hybrid beamforming (HBF) is typically employed to achieve satisfactory beamforming gains with reasonable hardware cost and power consumption. Due to the coupling of the analog and digital precoders in HBF and the dual objective in JCAS, JCAS-HBF design problems are very challenging and usually require highly complex algorithms. In this paper, we propose a fast HBF design for JCAS based on deep unfolding to optimize a tradeoff between the communications rate and sensing accuracy. We first derive closed-form expressions for the gradients of the communications and sensing objectives with respect to the precoders and demonstrate that the magnitudes of the gradients pertaining to the analog precoder are typically smaller than those associated with the digital precoder. Based on this observation, we propose a modified projected gradient ascent (PGA) method with significantly improved convergence. We then develop a deep unfolded PGA scheme that efficiently optimizes the communications-sensing performance tradeoff with fast convergence thanks to the well-trained hyperparameters. In doing so, we preserve the interpretability and flexibility of the optimizer while leveraging data to improve performance. Finally, our simulations demonstrate the potential of the proposed deep unfolded method, which achieves up to 33.5% higher communications sum rate and 2.5 dB lower beampattern error compared with the conventional design based on successive convex approximation and Riemannian manifold optimization. Furthermore, it attains up to a 65% reduction in run time and computational complexity with respect to the PGA procedure without unfolding.
Platelet Recruitment in the Murine Hepatic Microvasculature During Experimental Sepsis: Role of Neutrophils (2006)

These findings indicate that sepsis is associated with a neutrophil-dependent recruitment of platelets in the liver microcirculation that impairs sinusoidal perfusion and may contribute to the liver dysfunction associated with sepsis.
The role of PCL reconstruction in knees with combined PCL and posterolateral corner deficiency (2007)

Although many PCL injuries are in combination with posterolateral corner (PLC) injuries, there has been little work done on combined injury reconstruction; the literature includes differing recommendations. It was hypothesised that a double-bundle PCL reconstruction would restore both posterior drawer and external rotation laxities closer to normal than an isolated single-bundle reconstruction in combined PCL plus PLC-deficient knees. However, it was also hypothesised that an isolated PCL reconstruction would still leave abnormal rotation laxity. In this controlled laboratory study, cadaver knee kinematics were measured electromagnetically with posterior drawer, external rotation, varus rotation loads applied, at sequential stages: intact; PCL-deficient; PCL plus PLC-deficient; double-bundle PCL reconstruction; single-bundle PCL reconstruction. The grafts were tensed using a posterior drawer laxity matching protocol. There was no significant difference between single- and double-bundle PCL reconstructions at any angle of flexion: both reconstructions restored posterior drawer to normal; neither reconstruction restored external rotation or varus laxity to normal. We concluded that, in combined PCL plus PLC deficiency, isolated PCL reconstruction only controls tibial posterior drawer, but is not sufficient to restore rotational laxity to normal. Double-bundle PCL reconstruction was not better than single-bundle, so the added complexity of double-bundle reconstruction does not seem to be justified by these results.
Optimizing Gain Shaping Filters with Neural Networks for Maximum Cable Capacity under Electrical Power Constraints (2020)

We experimentally demonstrate capacity gains of up to 23% under electrical supply power constraints in a long-haul optical fiber cable by optimizing the gain shaping filters using neural networks.
A Narrow Bandwidth Microstrip Band-Pass Filter with Symmetrical Frequency Characteristics (2005)

This letter proposes a band-pass filter (BPF) with two transmission zeros based on a combination of parallel coupling and end coupling of half-wave transmission lines. The fabricated BPF exhibited a narrow bandwidth and two transmission zeros near the pass-band due to the end-coupled and shielding waveguide. At the center operation frequency of 60 GHz, the 20 dB bandwidth of the BPF is 1.0 GHz, which is almost 2% of the center operation frequency, and the insertion loss is 3.12 dB. Two transmission zeros reach approximately 40 dB at 58.5 and 62.5 GHz. The simulation results almost agree with the measured results.
YEATS4 Is a Novel Oncogene Amplified in Non–Small Cell Lung Cancer That Regulates the p53 Pathway (2013)

Genetic analyses of lung cancer have helped found new treatments in this disease. We conducted an integrative analysis of gene expression and copy number in 261 non-small cell lung cancers (NSCLC) relative to matched normal tissues to define novel candidate oncogenes, identifying 12q13-15 and more specifically the YEATS4 gene as amplified and overexpressed in ~20% of the NSCLC cases examined. Overexpression of YEATS4 abrogated senescence in human bronchial epithelial cells. Conversely, RNAi-mediated attenuation of YEATS4 in human lung cancer cells reduced their proliferation and tumor growth, impairing colony formation and inducing cellular senescence. These effects were associated with increased levels of p21WAF1 and p53 and cleavage of PARP, implicating YEATS4 as a negative regulator of the p21-p53 pathway. We also found that YEATS4 expression affected cellular responses to cisplastin, with increased levels associated with resistance and decreased levels with sensitivity. Taken together, our findings reveal YEATS4 as a candidate oncogene amplified in NSCLC, and a novel mechanism contributing to NSCLC pathogenesis.
Fabrication of Silicon Oxide Thin Films by Mist Chemical Vapor Deposition Method from Polysilazane and Ozone as Sources (2012)

Silicon oxide thin films were grown from the liquid source, polysilazane, by using mist chemical vapor deposition (CVD) at temperatures of 200–350 °C. The films were grown with a reasonable growth rate of 12 nm/min at the temperature of 200 °C, and they showed resistivity of the order of 1013 Ω·cm, although the incorporation of carbon and oxygen remains as a problem to be discussed and solved in the future. The results are encouraging for the future application of mist CVD for the growth of silicon oxide films on plastic substrates.
Design of Asymmetric Particles Containing a Charged Interior and a Neutral Surface Charge: Comparative Study on in Vivo Circulation of Polyelectrolyte Microgels (2014)

Lowering the modulus of hydrogel particles could enable them to bypass in vivo physical barriers that would otherwise filter particles with similar size but higher modulus. Incorporation of electrolyte moieties into the polymer network of hydrogel particles to increase the swelling ratio is a straightforward and quite efficient way to decrease the modulus. In addition, charged groups in hydrogel particles can also help secure cargoes. However, the distribution of charged groups on the surface of a particle can accelerate the clearance of particles. Herein, we developed a method to synthesize highly swollen microgels of precise size with near-neutral surface charge while retaining interior charged groups. A strategy was employed to enable a particle to be highly cross-linked with very small mesh size, and subsequently PEGylated to quench the exterior amines only without affecting the internal amines. Acidic degradation of the cross-linker allows for swelling of the particles to microgels with a desired size and deformability. The microgels fabricated demonstrated extended circulation in vivo compared to their counterparts with a charged surface, and could potentially be utilized in in vivo applications including as oxygen carriers or nucleic acid scavengers.
Relationship between facilitation at threshold and suprathreshold contour integration (1998)

We reevaluate the facilitation at threshold previously reported between aligned micropatterns and assess the role of such lateral spatial interactions in suprathreshold contour integration tasks. Contrary to previous claims, we show that these interactions are phase dependent. Furthermore, they are clearly evident only for foveal viewing, are not evident for curved alignments (> 20 degrees), and do not produce any suprathreshold consequence for contrast perception. Such findings question their usefulness for contour integration of smoothly curved suprathreshold paths.
Modal Interferometer Based on a C-Shaped Ultrathin Fiber Taper for High-Sensitivity Refractive Index Measurement (2011)

The ultrathin fiber taper fabricated by adiabatically stretching a heated single-mode optical fiber (SMF) is made in a C-shape bent to form a modal interferometer. The interference fringes due to the mode beating in the multimode taper waist are dependent on the bending radius. Under an optimized bending radius, a maximum 18 dB interference depth can be obtained. The influence of the fiber taper geometry on the interference fringes is discussed. The proposed modal interferometer has a high refractive index (RI) sensitivity of ∼658 nm/RIU (refractive index unit) for RI= 1.333–1.353, which is expected to be useful for precision bio/chemical sensing applications.
Genetic influences of ? adrenergic receptors polymorphisms on aortic stiffness and left ventricular hypertrophy in patients with essential hypertension (2004)

Journal Article OR 44: Genetic influences of β adrenergic receptors polymorphisms on aortic stiffness and left ventricular hypertrophy in patients with essential hypertension Get access Ming Yuan, Ming Yuan 1Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Mitsuru Ohishi, Mitsuru Ohishi 1Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Norihisa Ito, Norihisa Ito 1Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ken Sugimoto, Ken Sugimoto 1Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Masaharu Kaibe, Masaharu Kaibe 1Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Takashi Takagi, Takashi Takagi 1Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Tomohiro Katsuya, Tomohiro Katsuya 1Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Hiromi Rakugi, Hiromi Rakugi 1Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Toshio Ogihara Toshio Ogihara 1Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Hypertension, Volume 17, Issue S1, May 2004, Page 19A, https://doi.org/10.1016/j.amjhyper.2004.03.043 Published: 01 May 2004
Fluctuations of light scattered by fractal clusters (1997)

Fluctuations in light scattering from a finite ensemble of fractal clusters are studied numerically and theoretically. It is shown that, for a wide range of wavelengths and angles, relative fluctuations in the scattered intensity are very close to 1 and do not depend on the number of monomers N in fractal clusters (whereas they are proportional to 1/N for trivial clusters). The relations describing fluctuations in the light scattering are suggested; they can be used to extract important information about properties and parameters of fractal pollutants in the atmosphere.
Faster return of investment in WDM networks when elastic transponders dynamically fit ageing of link margins (2016)

We illustrate the cost reduction during 10-year life of a core WDM network enabled by elastic transponders when accounting directly for end-of-life OSNR detection margins, compared to margins progressively growing with network ageing.
SINR analysis of full-duplex OFDM repeaters (2009)

We study the performance of a two-hop full-duplex OFDM relay link, where the relay, or in-band repeater, amplifies and forwards its input signal on the same channel as the main transmitter. We derive new closed-form expressions for the end-to-end signal-to-interference and noise ratio (SINR) when the multipath channels are modeled with clustered exponential power-delay profiles. Our system model incorporates the deleterious effect of loop interference associated with full-duplex relays due to signal leakage from transmission to reception. In particular, our analysis shows that the relay gain is a central parameter in the mitigation of residual loop interference and for the optimization of the end-to-end performance.