gebhart/patrepeval huggingface dataset:
Development and anatomic localization of torsinA. (2004)

We have mapped the distribution of torsinA, the protein that is mutated in dystonia type 1 (DYT1), during postnatal development in rat brain. TorsinA was expressed in most brain regions at postnatal day 7, and its expression became more intense and widespread with age. The distribution of torsinA, however, showed marked age-dependent differences among regions of the cerebral cortex and hippocampus. Notably, large cholinergic interneurons of the striatum displayed intense torsin labeling between postnatal days 14 and 21, a period of intense synaptogenesis in this region.
DFT simulations of inter-graphene-layer coupling with rotationally misaligned hBN tunnel barriers in graphene/hBN/graphene tunnel FETs (2016)

Van der Waal's heterostructures allow for novel devices such as two-dimensional-to-two-dimensional tunnel devices, exemplified by interlayer tunnel FETs. These devices employ channel/tunnel-barrier/channel geometries. However, during layer-by-layer exfoliation of these multi-layer materials, rotational misalignment is the norm and may substantially affect device characteristics. In this work, by using density functional theory methods, we consider a reduction in tunneling due to weakened coupling across the rotationally misaligned interface between the channel layers and the tunnel barrier. As a prototypical system, we simulate the effects of rotational misalignment of the tunnel barrier layer between aligned channel layers in a graphene/hBN/graphene system. We find that the rotational misalignment between the channel layers and the tunnel barrier in this van der Waal's heterostructure can significantly reduce coupling between the channels by reducing, specifically, coupling across the interface between the channels and the tunnel barrier. This weakened coupling in graphene/hBN/graphene with hBN misalignment may be relevant to all such van der Waal's heterostructures.
Q-factor monitoring for fault management applications (2004)

We show that a sensitivity of 0.5 dB is required for using Q-factor to monitor noise for fault localization and analyze monitoring without dispersion compensation in 10 Gb/s networks with symmetric dispersion maps.
Development of x-ray topographic microscopy for the study of electromigration in interconnects (2003)

We have performed x-ray topography experiments in a new configuration using a Fresnel zone plate to form a magnified image of the sample intensity distribution on the detector plane. The main difference from the x-ray topography techniques where no optics is used between the sample and the detector, is the absence of free space propagation effects in the image and the possibility to form a magnified image. Other advantages include large working distance around the sample and low background radiation on the detector. As a first application, we recorded x-ray topographs of an Al interconnect structure as a function of time in an &lt;em&gt;in situ&lt;/em&gt; electromigration experiment. The contrast in the images is explained in terms of lattice deformations caused by the stress in the metal films. The results show the evolution of stress due to the electromigration process. The technique should make it possible to obtain best possible spatial resolution allowed by the sample in x-ray topography.
Intramolecular hydride shift polymerization by cationic mechanism. IV. Cationic isomerization polymerization of vinylcyclohexane (1964)

Abstract The cationic polymerization of vinylcyclohexane was investigated with the use of AlCl 3 catalyst at temperatures ranging from −144 to +7°C. The structure of the polymer was elucidated by NMR and infrared spectroscopy. These studies indicate that cationically synthesized polyvinylcyclohexane contains predominantly repeat units of the type: magnified image which suggests hydride shift isomerization polymerization.
Design of Web-based Security Management for Intrusion Detection (2002)

This article is a snapshot of the origins of immunotherapy use in this patient population as well as a guide to its future use. The author's hope with this article is to describe the patient population as well as the history of the integration of immunotherapy use into the adjuvant treatment of endometrial cancer leading up to FDA approval of Pembrolizumab and Dostarlimab. This article also consolidates the current literature as well as ongoing clinical trials that will hopefully lead to FDA approval of more immunotherapeutic agents in the near future.
Experimental Study of Mechanistic Acid Deconstruction of Lignin (2012)

Lignin is a major component of biomass, which remains highly underutilized in selective biomass conversion strategies to renewable fuels and chemicals. Here we are interested in studying the mechanisms related to the acid deconstruction of lignin with a combined theoretical and experimental approach. Quantum mechanical calculations were employed to elucidate possible deconstruction mechanisms with transition state theory. Model dimers, imitating H, S, and G lignins, were synthesized with the most abundant {beta} - O - 4 linkage in lignin. These compounds were then depolymerized using various acids and at different operating conditions. The deconstruction products were analyzed to complement the QM studies and investigate proposed mechanisms.
Antigen receptor sequencing of paired bone marrow samples shows homogeneous distribution of acute lymphoblastic leukemia subclones (2017)

In B-cell precursor acute lymphoblastic leukemia, the initial leukemic cells share the same antigen receptor gene rearrangements. However, due to ongoing rearrangement processes, leukemic cells with different gene rearrangement patterns can develop, resulting in subclone formation. We studied leukemic subclones and their distribution in the bone marrow and peripheral blood at diagnosis. Antigen receptor gene rearrangements (IGH, IGK, TRG, TRD, TRB) were analyzed by next-generation sequencing in seven paired bone marrow samples and five paired bone marrow-peripheral blood samples. Background-thresholds were defined, which enabled identification of leukemic gene rearrangements down to very low levels. Paired bone marrow analysis showed oligoclonality in all 7 patients and up to 34 leukemic clones per patient. Additional analysis of evolutionary-related IGH gene rearrangements revealed up to 171 leukemic clones per patient. Interestingly, overall 86% of all leukemic gene rearrangements, including small subclones, were present in both bone marrow samples (range per patient: 72-100%). Paired bone marrow-peripheral blood analysis showed that 83% of all leukemic gene rearrangements in bone marrow were also found in peripheral blood (range per patient: 81-100%). Remarkably, in the paired bone marrow samples and paired bone marrow-peripheral blood samples the vast majority of leukemic gene rearrangements had a similar frequency (<5-fold frequency difference) (96% and 96% of leukemic rearrangements, respectively). Together, these results indicate that B-cell precursor acute lymphoblastic leukemia is generally highly oligoclonal. Nevertheless, the vast majority of leukemic clones, even the minor antigen receptor-defined subclones, are homogeneously distributed throughout the bone marrow and peripheral blood compartment.
Immunoassay detection of drugs in racing horses. XI. ELISA and RIA detection of fentanyl, alfentanil, sufentanil and carfentanil in equine blood and urine. (1989)

We have developed and evaluated a one step enzyme-linked immunosorbent assay (ELISA) test for sufentanil and a 125I radioimmunoassay test for alfentanil as part of a panel of pre- and post-race tests for narcotic analgesics in racing horses. Our sufentanil ELISA test detects sufentanil with an I-50 of about 0.5 ng/ml. The test is rapid and economical in that it can be read with an inexpensive spectrophotometer, or even by eye. The test readily detects the presence of sufentanil or its metabolites in equine blood and urine from 1 to 24 hours respectively after administration of therapeutic or sub-therapeutic doses of this drug. Our sufentanil assay also cross-reacts with fentanyl, the methylated analogs of fentanyl (designer fentanyls), and carfentanil and detected these drugs in urine for several hours after their administration to horses. It does not, however, cross-react significantly with alfentanil. We have also developed an 125I radioimmunoassay for alfentanil. This test allows detection of alfentanil in blood and urine of horses for up to 4 hours after administration of this drug. As such, these tests are capable of improving the quality and reducing the cost of pre-race and post-race testing for fentanyl, sufentanil, carfentanil and alfentanil and a number of their congeners in racing horses. Similarly, these tests are capable of screening for these drugs in human drug abuse monitoring.
19.3: Thin Crystal Films (TCF) for LCD Color Correction (2003)

Abstract This paper describes an investigation on the application of Optiva thin‐crystal film (TCF) coatings for the correction of color errors and color variations in liquid crystal displays (LCDs). A yellow TCF polarizer coating was developed as a supplementary color correction coating for LCDs. Modeling and simulation of a normally‐white, film‐compensated AMLCD with and without the supplementary coating revealed that the yellow TCF polarizer coating neutralized the chromaticity of the display black point and dramatically reduced the migration of white point chromaticity across the gray scale range while leaving the display contrast ratio and transmission essentially unchanged. Display evaluations have confirmed the results of these simulations.
Levels of Cyclooxygenase-2 Are Increased in the Oral Mucosa of Smokers: Evidence for the Role of Epidermal Growth Factor Receptor and Its Ligands (2005)

Cyclooxygenase-2 (COX-2) is a promising pharmacologic target for preventing aerodigestive malignancies. In this study, we investigated the effects of tobacco smoke on the expression of COX-2 in oral mucosa. An approximately 4-fold increase in amount of COX-2 mRNA was observed in the oral mucosa of active smokers versus never smokers. Thus, a series of in vitro studies were carried out to elucidate the mechanism by which tobacco smoke induced COX-2. Treatment of a nontumorigenic oral epithelial cell line (MSK-Leuk1) with a saline extract of tobacco smoke (TS) stimulated COX-2 transcription, resulting in increased amounts of COX-2 mRNA, COX-2 protein, and prostaglandin E(2) (PGE(2)) synthesis. Exposure of cells to TS also caused an increase in epidermal growth factor receptor (EGFR) tyrosine kinase activity. Both an inhibitor of EGFR tyrosine kinase activity and a neutralizing anti-EGFR antibody blocked TS-mediated induction of COX-2. To define the mechanism by which TS activated EGFR, the release of amphiregulin and transforming growth factor alpha, two ligands of the EGFR, was measured. Exposure to TS caused a rapid increase in the release of both ligands. TS also markedly induced the expression of mRNAs for amphiregulin and transforming growth factor alpha. Importantly, increased expression of both ligands was also detected in the oral mucosa of active smokers. Taken together, these results suggest that activation of EGFR signaling contributes to the elevated levels of COX-2 found in the oral mucosa of smokers. Moreover, these findings strengthen the rationale for determining whether inhibitors of COX-2 or EGFR tyrosine kinase activity can reduce the risk of tobacco smoke-related malignancies of the aerodigestive tract.
Tunable and broadband photonic integrated circuits using metasurfaces for the generation and detection of orbital-angular-momentum beams (2022)

Integrated photonic circuits hold the promise of cost-effective and compact elements to generate and detect beams of a specific topological mode order of orbital-angular-momentum (OAM). This keynote will describe various metasurface structures that can be used for generating and detecting such OAM beams. The presentation will emphasize key beneficial characteristics for system operation, including the ability to dynamically tune the mode order and to perform functions over a broad spectral band.
MPLP++: Fast, Parallel Dual Block-Coordinate Ascent for Dense Graphical Models (2020)

Dense, discrete Graphical Models with pairwise potentials are a powerful class of models which are employed in state-of-the-art computer vision and bio-imaging applications. This work introduces a new MAP-solver, based on the popular Dual Block-Coordinate Ascent principle. Surprisingly, by making a small change to the low-performing solver, the Max Product Linear Programming (MPLP) algorithm, we derive the new solver MPLP++ that significantly outperforms all existing solvers by a large margin, including the state-of-the-art solver Tree-Reweighted Sequential (TRWS) message-passing algorithm. Additionally, our solver is highly parallel, in contrast to TRWS, which gives a further boost in performance with the proposed GPU and multi-thread CPU implementations. We verify the superiority of our algorithm on dense problems from publicly available benchmarks, as well, as a new benchmark for 6D Object Pose estimation. We also provide an ablation study with respect to graph density.
EM modeling of metal pipe based UHF RFID tags activated by R/W antenna (2012)

This paper presents the full-wave EM simulation and analysis of UHF RFID R/W antenna exciting the IC tag placed inside the coaxial metal pipe. The practical need for such a simulation model has followed the specific problem of activating the RFID tag being placed inside the hollow metal pipe. An original approach to match the characteristic impedance of the coaxial waveguide to that of the free space and to activate an IC tag installed inside the metal pipe will be explained. Various numerical data illustrating the mechanism of activating the IC tag inside the coaxial waveguide by incoming CP wave from the RFID R/W antenna will be presented.
GTI-Gradiant at TASS 2015: A Hybrid Approach for Sentiment Analysis in Twitter (2015)

acticas. Abstract: This paper describes the participation of the GTI research group of AtlantTIC, University of Vigo, and Gradiant (Galician Research and Development Centre in Advanced Telecommunications), in the tass 2015 workshop. Both groups have worked together in the development of a hybrid approach for sentiment anal- ysis, at a global level, of Twitter, proposed in task 1 of tass. A system based on classiers and unsupervised approaches, built with polarity lexicons and syntactic
Ozonolysis of Allenes and Alkylidenecyclopropanes (Homoallenes) (2001)

Allenyl methyl ether (1) and (diphenylmethylene)cyclopropane (5) were ozonized with an ozone/oxygen mixture. Formation of the observed products cannot be satisfactorily rationalized via the familiar modified Criegee mechanism. However, a single-electron transfer (SET) mechanism provides a simple rationale.
Supplementary Figure S6 from Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance (2023)

&lt;p&gt;Supplementary Figure S6. Validation of ADAM10 and ADAM17 siRNA knockdown in MDA-MB157 and MDA-MB231, assessed by live-cell immunostaining and confirmed at right by western blot in MDA-MB231 (*p&lt;0.05).&lt;/p&gt;
Retinal Stimulation on Rabbit Using Complementary Metal Oxide Semiconductor Based Multichip Flexible Stimulator toward Retinal Prosthesis (2008)

The Functionality of a complementary metal oxide semiconductor (CMOS) LSI-based, multichip flexible retinal stimulator was demonstrated in retinal stimulation experiments on rabbits. A 1×4-configured multichip stimulator was fabricated for application to experiments on animals. An experimental procedure including surgical operations was developed, and retinal stimulation was performed with the fabricated multichip stimulator. Neural responses on the visual cortex were successfully evoked by the fabricated stimulator. The stimulator is confirmed to be applicable to acute animal experiments.
ChemInform Abstract: Regioselective Diels‐Alder Reactions of N‐Cyanoindole‐4,7‐diones: Elaboration of the A‐Ring of the Kinamycins on a BC Ring Template. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An investigation of the chemistry of phenylsulphonylcyclopentadiene (1983)

Phenylsulphonylcyclopentadiene (7) exists mainly as the 1-isomer, and the assigned structure of its dimer (6) has been corroborated by n.m.r. decoupling experiments. Both the diene (7) and its cyclopentadienide anion (8) were unusually unreactive, although anion (8) rapidly perdeuteriates and undergoes Michael addition, α to the sulphonyl group, to methyl vinyl ketone, albeit in very low yield to form adduct (11). On being heated to 65 °C compound (11) rearranges, and two consecutive 1,5-shift products have been tentatively identified by n.m.r. spectroscopy.
Time frequency analysis of the coconut rhinoceros beetle chirps (2016)

The Coconut Rhinoceros Beetle attacks the coconut palm trees in the Pacific Region and its foraging has led to the devastion of the palm trees in Guam. The beetle is an invasive species on the island of Oahu, Hawaii, since its latent arrival in 2013. Stridulation sounds produced by the beetles have been reported with respect to mating and aggressive male behavior. Previous studies have proposed the mechanism for the stridulation and reported on some preliminary acoustic recording of the chirp for groups of beetles. However, the chrip characteristics wth respect to different behavior have not been examined extensively and also the time frequency analysis of the chirp sounds specifically or male and female beetles has been limited. In laboratory setting, the chirp characteristics are investigated with respect individual beetles in terms of pulse length and chrip duration. Time frequency analysis is used quantifiy the frequency modulation. An Empirical Mode Decompositon (EMD) provides a means of determing the instantaneous frequency and phase. Sounds of wing beats during the beetle's take off and flight are also investigated.
New heteroleptic iridium complexes having one biphenyl-2,2′-diyl and two bipyridyl based ligands (2009)

The structural and spectroscopic properties of new heteroleptic iridium complexes having a biphenyl and two bipyridyl based ligands are reported; DFT calculations reveal that the HOMO is composed of the biphenyl and iridium d orbitals while the LUMO is localized mainly on the two bipyridyl based ligands.
Hyperhomocysteinaemia, Helicobacter pylori, and coronary heart disease. (1996)

Hyperhomocysteinaemia and Helicobacter pylori infection have recently been implicated in the pathogenesis of coronary artery disease. These two risk factors, though they seem unrelated, could be linked by a deficiency of vitamins and folate caused by chronic gastritis in H pylori infection. This nutritional defect could lead to failure of methylation by 5-methyl-tetrahydrofolic acid and thus exacerbate the accumulation of homocysteine in susceptible patients. Homocysteine is toxic to endothelial cells and results in coronary artery disease.
Ultrafast and nonlinear surface-enhanced Raman spectroscopy (2016)

Ultrafast surface-enhanced Raman spectroscopy (SERS) has the potential to study molecular dynamics near plasmonic surfaces to better understand plasmon-mediated chemical reactions such as plasmonically-enhanced photocatalytic or photovoltaic processes. This review discusses the combination of ultrafast Raman spectroscopic techniques with plasmonic substrates for high temporal resolution, high sensitivity, and high spatial resolution vibrational spectroscopy. First, we introduce background information relevant to ultrafast SERS: the mechanisms of surface enhancement in Raman scattering, the characterization of plasmonic materials with ultrafast techniques, and early complementary techniques to study molecule-plasmon interactions. We then discuss recent advances in surface-enhanced Raman spectroscopies with ultrafast pulses with a focus on the study of molecule-plasmon coupling and molecular dynamics with high sensitivity. We also highlight the challenges faced by this field by the potential damage caused by concentrated, highly energetic pulsed fields in plasmonic hotspots, and finally the potential for future ultrafast SERS studies.
Layered ST Codes (2006)

This chapter contains sections titled: Blast Designs ST Codes Trading Diversity For Rate Full-Diversity Full-Rate ST Codes Numerical Examples Closing Comments
CCDC 812001: Experimental Crystal Structure Determination (2011)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Polar and steric effects in the homolytic amination of alkylbenzenes and biphenyl (1974)

Partial rate factors for homolytic amination of alkylbenzenes and biphenyl by N-chloroamines have been determined in an acidic medium. The resulting polar effects are by far the highest ever observed in homolytic substitution and are of the order of magnitude of those in the common electrophilic reactions. The reaction is sensitive to steric and polar effects (conjugative and inductive, but not hyperconjugative), as previously observed for hydrogen absractions. The transition state of the reaction is discussed and a hypothesis is put forward on inductive and Baker–Nathan effects on electrophilic substitution.