gebhart/patrepeval huggingface dataset:
Co60 radiation control using thin film coatings (1986)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation T. V. Rao, B. Oral, G. T. Stauf, R. W. Vook, W. Meyer; Co60 radiation control using thin film coatings. J. Vac. Sci. Technol. A 1 November 1986; 4 (6): 3055–3058. https://doi.org/10.1116/1.573627 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAVS: Science & Technology of Materials Interfaces and ProcessingJournal of Vacuum Science & Technology A Search Advanced Search |Citation Search
Tomographic Imaging on Distributed Unattended Ground Sensor Arrays (2002)

The objective of this project was to demonstrate tomographic data fusion from distributed ground sensor arrays. The project leveraged other DARPA work by the same researchers at the University of Illinois on the topic of interferometric digital imaging. The current program was oriented toward design of an array of imaging sensors, including both cameras and interferometric sensors, to accurately and robustly locate and track ground targets. Over the course of this project we designed and constructed five first-generation sensor modules. Four of these modules were fitted with 180-degree panorama video sensor heads, while the fifth used a sensor head consisting of a rotational shearing interferometer. Two modules were used in field tests with IR cameras replacing the visible-light sensor heads. In a second field test, four modules with visible-light CMOS cameras were used to demonstrate tomographic imaging of a human subject moving through a test environment. In addition, a smaller, low-power second generation module, based on the StrongArm processor, was designed, assembled and tested.
Smart Spaces for Ubiquitously Smart Buildings (2009)

Building automation is a domain where interoperability between equipment made by different manufacturers is rare. In addition to competing standards, completely proprietary solutions are also common. This is a great challenge for implementing ‘ubiquitously smart buildings’, where building automation systems, user interfaces and services can interact seamlessly. The paper describes how a Semantic Information Broker (SIB) can be used as an enabler of interoperability, where an ecosystem of supplementary services is created through manufacturer-agnostic agents.
Understanding and Tackling the Root Causes of Instability in Wireless Mesh Networks (2011)

We investigate, both theoretically and experimentally, the stability of CSMA-based wireless mesh networks, where a network is said to be stable if and only if the queue of each relay node remains (almost surely) finite. We identify two key factors that impact stability: the network size and the so-called “stealing effect,” a consequence of the hidden-node problem and nonzero transmission delays. We consider the case of a greedy source and prove, by using Foster's theorem, that three-hop networks are stable, but only if the stealing effect is accounted for. We also prove that four-hop networks are, on the contrary, always unstable (even with the stealing effect) and show by simulations that instability extends to more complex linear and nonlinear topologies. To tackle this instability problem, we propose and evaluate a novel, distributed flow-control mechanism called EZ-flow. EZ-flow is fully compatible with the IEEE 802.11 standard (i.e., it does not modify headers in packets), can be implemented using off-the-shelf hardware, and does not entail any communication overhead. EZ-flow operates by adapting the minimum congestion window parameter at each relay node, based on an estimation of the buffer occupancy at its successor node in the mesh. We show how such an estimation can be conducted passively by taking advantage of the broadcast nature of the wireless channel. Real experiments, run on a nine-node test-bed deployed over four different buildings, show that EZ-flow effectively smooths traffic and improves delay, throughput, and fairness performance.
STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters (2020)

Introductory paragraph Since the emergence of SARS-CoV-2 causing COVID-19, the world is being shaken to its core with numerous hospitalizations and hundreds of thousands of deaths. In search for key targets of effective therapeutics, robust animal models mimicking COVID-19 in humans are urgently needed. Here, we show that productive SARS-CoV-2 infection in the lungs of mice is limited and restricted by early type I interferon responses. In contrast, we show that Syrian hamsters are highly permissive to SARS- CoV-2 and develop bronchopneumonia and a strong inflammatory response in the lungs with neutrophil infiltration and edema. Moreover, we identify an exuberant innate immune response as a key player in pathogenesis, in which STAT2 signaling plays a dual role, driving severe lung injury on the one hand, yet restricting systemic virus dissemination on the other. Finally, we assess SARS-CoV- 2-induced lung pathology in hamsters by micro-CT alike used in clinical practice. Our results reveal the importance of STAT2-dependent interferon responses in the pathogenesis and virus control during SARS-CoV-2 infection and may help rationalizing new strategies for the treatment of COVID-19 patients.
Supplementary Table S2 from Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles (2023)

&lt;p&gt;Annotation of 1163 ORFs.&lt;/p&gt;
Data from Poly(ADP-Ribose) Polymerase-1 Inhibitor Treatment Regresses Autochthonous <i>Brca2/p53</i>-Mutant Mammary Tumors <i>In vivo</i> and Delays Tumor Relapse in Combination with Carboplatin (2023)

&lt;div&gt;Abstract&lt;p&gt;Germ-line heterozygosity of the &lt;i&gt;BRCA2&lt;/i&gt; gene in women predisposes to breast and ovarian cancers. Successful therapies targeted specifically at these neoplasms have thus far remained elusive. Recent studies in mice have shown that inhibition of poly(ADP-ribose) polymerase-1 (PARP-1) targets cells lacking &lt;i&gt;Brca2&lt;/i&gt; and xenografts derived from &lt;i&gt;BRCA2&lt;/i&gt;-deficient ES cells or Chinese hamster ovary cells. We set out to develop a more relevant preclinical model that will inform and accelerate translation into the clinic. As such, we conditionally deleted &lt;i&gt;Brca2&lt;/i&gt; and &lt;i&gt;p53&lt;/i&gt; within murine mammary epithelium and treated the resulting tumors &lt;i&gt;in situ&lt;/i&gt; with a highly potent PARP-1 inhibitor (AZD2281) alone or in combination with carboplatin. Daily exposure to AZD2281 for 28 days caused significant regression or growth inhibition in 46 of 52 tumors. This response was shown to be specific to tumors lacking both &lt;i&gt;Brca2&lt;/i&gt;and &lt;i&gt;p53&lt;/i&gt;. AZD2281/carboplatin combination therapy for 28 days showed no advantage over carboplatin monotherapy. However, if PARP inhibitor treatment was continued, this significantly increased the time to tumor relapse and death in these mice. This preclinical study is the first to show &lt;i&gt;in vivo&lt;/i&gt; hypersensitivity of spontaneously arising &lt;i&gt;Brca2&lt;/i&gt;-deficient mammary tumors to PARP-1 inhibition monotherapy or combination therapy. As such, our data add substantial weight to the argument for the use of PARP inhibitors as therapeutic agents against human breast cancers in which BRCA2 is mutated. Moreover, the specificity that we have shown further suggests that PARP inhibitors will be generally effective against tumors caused by dysregulation of components of the homologous recombination pathway. [Cancer Res 2009;69(9):3850–55]&lt;/p&gt;&lt;/div&gt;
On the Design of Nonlinear Distributed Control Protocols for Platooning Systems (2017)

In this letter, we introduce a novel sufficient condition for the stability of acyclic directed networks subject to time- and state-dependent disturbances. Such a condition, which essentially characterizes the behavior of the network in terms of the solutions of its unperturbed dynamics, is applied to address the problem of designing distributed control protocols for vehicle platooning. Specifically, we show how it can be used to design both linear and nonlinear distributed control protocols for the stable platooning of a network of automated vehicles. We illustrate the effectiveness of our approach via a representative example.
ChemInform Abstract: Two Theonellapeptolide Congeners from Marine Sponge Theonella sp. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Rationally Based Efficacy Tuning of Selective Dopamine D4 Receptor Ligands Leading to the Complete Antagonist 2-[4-(4-Chlorophenyl)piperazin-1- ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213) (2001)

Structure dependent efficacy studies in the field of selective D4 ligands led to the 2-aminomethyl substituted azaindole 2 (FAUC 213) that displayed strong D4 binding, high subtype selectivity, and complete antagonist properties in ligand-induced mitogenesis experiments. According to our schematic molecular model, the intrinsic activity of the regioisomers investigated is controlled by the ability of the heterocyclic unit to interact with both elements of the D4 binding-site crevice, the aromatic microdomain in TM6, and a serine residue in TM5.
Centrality dependence of J/ψ and ψ(2S) production and nuclear modification in p-Pb collisions at $$ \sqrt{s_{\mathrm{NN}}} $$ = 8.16 TeV (2021)

A bstract The inclusive production of the J/ ψ and ψ (2S) charmonium states is studied as a function of centrality in p-Pb collisions at a centre-of-mass energy per nucleon pair $$ \sqrt{s_{\mathrm{NN}}} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:msub> <mml:mi>s</mml:mi> <mml:mi>NN</mml:mi> </mml:msub> </mml:msqrt> </mml:math> = 8 . 16 TeV at the LHC. The measurement is performed in the dimuon decay channel with the ALICE apparatus in the centre-of-mass rapidity intervals − 4 . 46 &lt; y cms &lt; − 2 . 96 (Pb-going direction) and 2 . 03 &lt; y cms &lt; 3 . 53 (p-going direction), down to zero transverse momentum ( p T ). The J/ ψ and ψ (2S) production cross sections are evaluated as a function of the collision centrality, estimated through the energy deposited in the zero degree calorimeter located in the Pb-going direction. The p T -differential J/ ψ production cross section is measured at backward and forward rapidity for several centrality classes, together with the corresponding average 〈 p T 〉 and $$ \left\langle {p}_{\mathrm{T}}^2\right\rangle $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mfenced> <mml:msubsup> <mml:mi>p</mml:mi> <mml:mi>T</mml:mi> <mml:mn>2</mml:mn> </mml:msubsup> </mml:mfenced> </mml:math> values. The nuclear effects affecting the production of both charmonium states are studied using the nuclear modification factor. In the p-going direction, a suppression of the production of both charmonium states is observed, which seems to increase from peripheral to central collisions. In the Pb-going direction, however, the centrality dependence is different for the two states: the nuclear modification factor of the J/ ψ increases from below unity in peripheral collisions to above unity in central collisions, while for the ψ (2S) it stays below or consistent with unity for all centralities with no significant centrality dependence. The results are compared with measurements in p-Pb collisions at $$ \sqrt{s_{\mathrm{NN}}} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:msub> <mml:mi>s</mml:mi> <mml:mi>NN</mml:mi> </mml:msub> </mml:msqrt> </mml:math> = 5 . 02 TeV and no significant dependence on the energy of the collision is observed. Finally, the results are compared with theoretical models implementing various nuclear matter effects.
Workflows for the Management of Change in Science, Technologies,\n Engineering and Mathematics (2011)

Mathematical knowledge is a central component in science, engineering, and\ntechnology (documentation). Most of it is represented informally, and -- in\ncontrast to published research mathematics -- subject to continual change.\nUnfortunately, machine support for change management has either been very\ncoarse grained and thus barely useful, or restricted to formal languages, where\nautomation is possible. In this paper, we report on an effort to extend change\nmanagement to collections of semi-formal documents which flexibly intermix\nmathematical formulas and natural language and to integrate it into a semantic\npublishing system for mathematical knowledge. We validate the long-standing\nassumption that the semantic annotations in these flexiformal documents that\ndrive the machine-supported interaction with documents can support semantic\nimpact analyses at the same time. But in contrast to the fully formal setting,\nwhere adaptations of impacted documents can be automated to some degree, the\nflexiformal setting requires much more user interaction and thus a much tighter\nintegration into document management workflows.\n
Optimized Power Control for Massive MIMO With Underlaid D2D Communications (2018)

In this paper, we consider device-to-device (D2D) communication that is underlaid in a multi-cell massive multiple-input multiple-output (MIMO) system and proposes a new framework for power control and pilot allocation. In this scheme, the cellular users (CUs) in each cell get orthogonal pilots which are reused with reuse factor one across cells, while all the D2D pairs share another set of orthogonal pilots. We derive a closed-form capacity lower bound for the CUs with different receive processing schemes. In addition, we derive a capacity lower bound for the D2D receivers and a closed-form approximation of it. We provide power control algorithms to maximize the minimum spectral efficiency (SE) and to maximize the product of the signal-to-interference-plus-noise ratios in the network. Different from prior works, in our proposed power control schemes, we consider joint pilot and data transmission optimization. Finally, we provide a numerical evaluation, where we compare our proposed power control schemes with the maximum transmit power case and the case of conventional multi-cell massive MIMO without D2D communication. Based on the provided results, we conclude that our proposed scheme increases the sum SE of multi-cell massive MIMO networks.
SAT-291 FUNGAL PERITONITIS IN PERITONEAL DIALYSIS PATIENTS: A 5-YEAR REVIEW, SINGLE CENTRE EXPERIENCE (2020)

Fungal peritonitis (FP) remains one of the feared complications of peritoneal dialysis (PD). As compared to bacterial peritonitis, FP leads to higher morbidity, which results in a higher number of catheter removal and conversion to long-term hemodialysis. We routinely prescribe syrup Nystatin as antifungal prophylaxis in all patients treated for bacterial PD peritonitis since early 2018. In this study, we analysed the incidence, risk factors and outcome of patients with FP over the past 5 years.
Clean up protein for analysis from salt-rich sample using facilitated by copper ion in micro-device (2008)

In this study, we made the simple and rapid microfluidic desalting systems. They are 3-phase flow micro-dialysis using simple diffusion and 5-phase flow micro-dialysis based on the coupling of simple diffusion and affinity of urea for the effective removal of urea. The facilitative desalting system is particularly useful for removal of urea and analysis of protein by mass spectroscopy because urea is removed by the mass transfer with the difference of concentration, molecular size and the affinity of urea to copper (II) ion resulting the complex. We also evaluated the activity and MALDI-TOF-MS spectrum of red fluorescent protein (RFP) for protein analysis.
Effects of Long Term Androgen and Estradiol Exposure on the Hypothalamus* (1983)

Evidence has accumulated indicating that estradiol induces degeneration in the hypothalamic arcuate nucleus of the rat. In contrast, testosterone appears to be relatively inert in this regard. The relative inability of testosterone to induce hypothalamic damage may account for the lack of effect of orchidectomy on senescent degeneration in the arcuate nucleus, whereas oophorectomy greatly suppresses this process. Since the hypothalamus has the enzyme system to aromatize testosterone to estradiol as well as that which reduces testosterone to 5α-dihydrotestosterone (DHT), it was decided to examine the effects and possible interaction of these two testosterone metabolites at the hypothalamic level. A system was designed in which the hypothalamus would receive long term exposure to estradiol, testosterone, or DHT alone or to estradiol combined with either testosterone or DHT. This was accomplished by implanting oophorectomized rats with sustained release capsules containing these steroids. Hypothalamic degeneration after the exposure was assessed by measuring microglial and astrocytic activity in the arcuate nucleus. Estradiol-implanted animals showed significant increases in both glial indices compared to blankimplanted controls, whereas testosterone-implanted animals showed a slight increase in microglial activity and no increase in astrocytic activity. DHT-implanted animals exhibited control levels of glial activity. Surprisingly, however, the combined treatment of DHT and estradiol also showed control levels of glial activity. These results indicate that constant low levels of estradiol are pathogenic to the arcuate nucleus and that 5α-reduced androgens may exert a potent and direct inhibitory effect on the neuropathogenic action of estradiol at the hypothalamic level. The antagonism between these two classes of testosterone metabolites may explain the relative nonpathogenicity of testosterone and the lack of participation of the testis in aging of the hypothalamic arcuate nucleus.
Control System and Experiment for RAON HWR Cryomodules (2018)

A prototype of half-wave resonator (HWR) cryomodules is fabricated and tested. Cables and tray are installed for horizontal test. The design and the piping and instrumentation diagram (P&amp;ID) of the HWR cryomodule are presented. The HWR cryomodule is tested with developed programmable logic controller (PLC) and experimental physics and industrial control system (EPICS) control systems. The heat loads of the HWR cryomodule for static and dynamic are measured.
Role of defective monocyte interleukin-10 release in tumor necrosis factor-alpha overproduction in alcoholic cirrhosis (1995)

Monocytes of patients with alcoholic cirrhosis produce higher amounts of tumor necrosis factor-alpha (TNF-alpha) after lipopolysaccharide (LPS) stimulation. The mechanisms of the overproduction remain undefined. IL-10 (IL-10) is an antiinflammatory cytokine known to downregulate TNF-alpha secretion by monocytes. The present study analyzes IL-10 production by monocytes and its control on TNF-alpha secretion in alcoholic cirrhosis. LPS-stimulated monocytes from alcoholic cirrhotics (n = 13) showed decreased IL-10 (median, 240 pg/mL [40 to 500] upsilon 513 pg/mL [152 to 1,335]; P = .01) compared with controls (n = 13). Cells from cirrhotic patients were normally responsive to recombinant IL-10, which induced a dose dependent decrease of TNF-alpha secretion. On the other hand, preincubation with anti-IL-10 monoclonal antibodies led to significant increase in TNF-alpha secretion in controls (median, 7,325 to 16,800 pg/mL; P = .002) but not in cells from cirrhotic patients (16,535 to 20,450 pg/mL; P = .14), abolishing the difference in TNF-alpha production between cirrhotic patients and controls. It is concluded that defective IL-10 secretion by monocytes from alcoholic cirrhotic patients could be involved in the characteristics TNF-alpha overproduction observed in this disease.
Controlling the growth of fullerene C60 cones under continuous flow (2018)

Micromixing of an o-xylene solution of C60 with N-N-dimethylformamide (DMF) at room temperature under continuous flow in a vortex fluidic device (VFD) results in the formation of symmetrical right cones in high yield with diameters 0.5 to 2.5 μm, pitch angle 25° to 55° and wall thickness 120 to 310 nm. Their formation is in the absence of surfactants and any other reagents, and is scalable. The cones are formed at specific operating parameters of the VFD, including rotational speed, flow rate and concentration, and varying these results in other structures such as grooved fractals. Other aromatic solvents in place of o-xylene results in the formation of rods, spicules and prisms, respectively for m-xylene, p-xylene and mesitylene.
71.4: High Efficiency and/or Low Cost LED Backlight System for Color Sequential Technique in Color Filter‐Less LCD System (2008)

Abstract This paper proposes a design methodology for implementing a high efficiency and/or a low cost RGB backlight module in color sequential notebook computers' display. A RGB LED driver composed of an asynchronous 1.5MHz DC/DC boost converter with dual loop control is fabricated by TSMC 0.25 μm BCD 40V to generate 17V or 21V output voltage to turn on more than 6 series‐red, 6 series‐green, or series‐blue LEDs at the same time for the notebooks' backlight. Besides, charge‐recycling technique is used to restore extra energy at the output node when switching to different forwarding light emitting diodes (LEDs) and release the energy next time. The total power consumption of a 15.4′ LCD panel of a notebook computer can be reduced from 5W to about 2–3W.