gebhart/patrepeval huggingface dataset:
Live cell tracking on an optical biochip platform (2007)

We have developed a range of optical biochip devices for conducting live and fixed cell-based assays. The devices encompass the ability to process an entire assay including fluorescently labelling cells, a microfluidic system to transport and maintain cells to deliver them to an optical area of the device for measurement, with the possibility of a incorporating a sorting step in between. On-chip excitation provided by red emitting LED and lasers define the excitation wavelength of the fluorophore to be incorporated into the assay readout. The challenge for such an integrated microfluidic optical biochip has been to identify and characterise a longterm fluorescent label suitable for tracking cell proliferation status in living cells. Traditional organic fluorophores have inherent disadvantages when considering their use for an on-chip device requiring longterm cellular tracking. This has led us to utilise inorganic quantum dots (QDots) as fluorophores for on- chip assays. QDs have unique properties such as photostability, broad absorption and narrow emission spectra and are available in a range of emission wavelengths including far red. They also have much higher quantum efficiencies than traditional organic fluorophores thus increasing the possible dynamic range for on-chip detection. Some of the QDots used have the added advantage of labelling intact cells and being retained and distributed among daughter cells at division, allowing their detection for up to 6 generations. The use of these QDs off-chip has suggested that they are ideal for live cell, non-perturbing labelling of division events, whereby over time the QD signal becomes diluted with each generation. Here we describe the use of quantum dots as live cell tracers for proliferating populations and the potential applications in drug screening and optical biochip environments.
Acute Tachycardia Increases Aortic Distensibility, but Reduces Total Arterial Compliance Up to a Moderate Heart Rate (2018)

<b>Background:</b> The differential effects of rapid cardiac pacing on small and large vessels have not been well-established. The objective of this study was to investigate the effect of pacing-induced acute tachycardia on hemodynamics and arterial stiffness. <b>Methods:</b> The pressure and flow waves in ascending aorta and femoral artery of six domestic swine were recorded simultaneously at baseline and heart rates (HR) of 135 and 155 beats per minutes (bpm) and analyzed by the models of Windkessel and Womersley types. Accordingly, the flow waves were simultaneously measured at carotid and femoral arteries to quantify aortic pulse wave velocity (PWV). The arterial distensibility was identified in small branches of coronary, carotid and femoral arteries with diameters of 300-600 μm by <i>ex vivo</i> experiments. <b>Results:</b> The rapid pacing in HR up to 135 bpm reduced the total arterial compliance, stroke volume, systemic pulse pressure, and central systolic pressure by 36 ± 17, 38 ± 26, 29 ± 16, and 23 ± 12%, respectively, despite no statistical difference of mean aortic pressure, cardiac output, peripheral resistance, and vascular flow patterns. The pacing also resulted in a decrease of distensibility of small muscular arteries, but an increase of aortic distensibility. Pacing from 135 to 155 bpm had negligible effects on systemic and local hemodynamics and arterial stiffness. <b>Conclusions:</b> There is an acute mismatch in the response of aorta and small arteries to pacing from basal HR to 135 bpm, which may have important pathological implications under chronic tachycardia conditions.
Is blood the ideal submucosal cushioning agent? A comparative study in a porcine model (2006)

Blood produces the most durable cushion compared with standard agents, also having the advantages of being readily available and without cost. Albumin 25 % provides as durable a cushion as hydroxypropyl methylcellulose.
Is PMD compensation really useful? (2004)

We compare the benefit of optical PMD compensation relative to improving the PMD tolerance by reducing system reach. PMDCs are found to have value in 10 and 40 Gb/s systems only for a limited range of the fiber PMD parameter.
Use of Proteomic Patterns in Serum to Identify Ovarian Cancer (2002)

Petricoin, Emanuel F. III; Ardekani, Ali M.; Hitt, Ben A.; Levine, Peter J.; Fusaro, Vincent A.; Steinberg, Seth M.; Mills, Gordon B.; Simone, Charles; Fishman, David A.; Kohn, Elise C.; Liotta, Lance A.
Global expression analysis of the fibroblast transcriptional response to TGFbeta. (2004)

This encyclopedic method revealed many unknown transcriptional responses to TGFbeta including the upregulation of a variety of less expected cytoskeletal and matrix components, as well as interactions between the TGFbeta and tumor necrosis factor (TNF) pathways and alterations in cell death-related pathways. These may in part explain the idiosyncratic responses of mesenchymal cells to TGFbeta.
Genetic-Algorithm Assisted Design of C-Band CROW-Miniaturized PCW Interleaver (2009)

We investigate the design of a miniaturized C-band photonic-crystal waveguide (PCW) interleaver, employing coupled-resonator optical waveguide (CROW) ring resonators. An optimization approach based on a genetic algorithm (GA) has been applied to the filter components, such as tapers and directional couplers, leading to low reflection and high phase linearity. To evaluate the interleaver transmittivity function, an S-matrix approach is worked out, based on the optimized building blocks. A sensitivity analysis is performed to evaluate the effect of parameter tolerances.
Optimierung pharmakologischer Innenohrtherapien im Meerschweinchen-Tiermodell – Modell zur Berechnung des Perilymphvolumens der Scala tympani (2023)

Einleitung Die Entwicklung pharmakologischer Therapien zur Vorbeugung und Behandlung von Innenohrerkrankungen ist sowohl in der Forschung als auch im klinischen Bereich aktuell. Das Meerschweinchen ist hierfür ein etabliertes Tiermodell. Die Ergebnisse von in-vivo Experimenten wie auch von klinischen Studien sind jedoch heterogen. Dies kann unter anderem auf die nicht berücksichtigte Individualität von Labortieren in Bezug auf die Größe und Form der Strukturen, sowie Volumina der Perilymphe zurückzuführen sein. Zielsetzung Bestimmung des Scala tympani (Sc.t) Volumens von frischen, gefrorenen und fixierten Meerschweinchen zur Entwicklung einer Planungssoftware zur Bestimmung des Sc.t. Volumens.
Optical monitoring of PMD accumulation on a Pol-MUX phase-modulated signal using degree-of-polarization measurements (2011)

We experimentally demonstrate a chromatic dispersion insensitive monitoring technique for monitoring of polarization mode dispersion and time misalignment in a 80 Gbit/s polarization-multiplexed return-to-zero differential phase-shift-keying (Pol-MUX RZ-DPSK) signal using a polarimeter and degree-of polarization (DOP) measurements. This technique is modulation format independent (i.e., applicable to both the phase- and amplitude-modulated data) and capable of measuring the fast change of polarization effects caused by vibration or other fast disturbances in the fiber link. We show that the monitored DOP of this signal decreases by 10.8% with differential group delay of 0-12 ps and decreases by 20% with a maximum misalignment of 12.5 ps between two orthogonally polarized RZ-DPSK channels. These measurements are less sensitive to chromatic dispersion of 0-400 ps/nm.
A Genetically Encoded Diazirine Photocrosslinker in Escherichia coli (2007)

Directed evolution. An orthogonal amber suppressor tRNA/aminoacyl–tRNA synthetase pair was evolved that allows the site-specific incorporation of 4′-[3-(trifluoromethyl)-3H-diazirin-3-yl]-L-phenylalanine into proteins in Escherichia coli with high efficiency and fidelity.
Reseña de: Toner, Jerry, Infamia: El crimen en la antigua Roma (2020)

Reseña de: Toner, Jerry, Infamia: El crimen en la antigua Roma, Madrid, Desperta Ferro Ediciones, 2020, 246 pp., ISBN: 978-84-120798-8-3
Question-Driven Design Process for Explainable AI User Experiences (2021)

A pervasive design issue of AI systems is their explainability--how to provide appropriate information to help users understand the AI. The technical field of explainable AI (XAI) has produced a rich toolbox of techniques. Designers are now tasked with the challenges of how to select the most suitable XAI techniques and translate them into UX solutions. Informed by our previous work studying design challenges around XAI UX, this work proposes a design process to tackle these challenges. We review our and related prior work to identify requirements that the process should fulfill, and accordingly, propose a Question-Driven Design Process that grounds the user needs, choices of XAI techniques, design, and evaluation of XAI UX all in the user questions. We provide a mapping guide between prototypical user questions and exemplars of XAI techniques to reframe the technical space of XAI, also serving as boundary objects to support collaboration between designers and AI engineers. We demonstrate it with a use case of designing XAI for healthcare adverse events prediction, and discuss lessons learned for tackling design challenges of AI systems.
XML programming with SQL/XML and XQuery (2002)

Most business data are stored in relational database systems, and SQL (Structured Query Language) is used for data retrieval and manipulation. With XML (Extensible Markup Language) rapidly becoming the de facto standard for retrieving and exchanging data, new functionality is expected from traditional databases. Existing SQL applications will evolve to retrieve relational data as XML data using database or SQL extensions for XML. New XML data will be stored, searched, and manipulated in the database as a “first class” citizen along with existing relational data. Furthermore, new applications will emerge which solely operate in terms of XML. These new XML applications operate on the same database using an XML query language, XQuery. In this paper, we describe an integrated database architecture that enables SQL applications with XML extensions as well as XQuery applications to operate on the same data. The architecture allows for a seamless flow from relational data to XML and back.
Skin impedance implications of TENS function and the development of an improved stimulation waveform (2002)

A modified Transcutaneous Electric Nerve Stimulator (TENS) stimulation waveform is being used in an experimental prototype unit. The waveform varies from those generated in traditional TENS in shape and spectral content. A pilot study of skin impedance using TENS electrodes was performed. Impedance characteristic Bode plots were made of subjects with prepared and unprepared skin. Spectral magnitudes were then compared to the spectral energies of a traditional TENS device stimulation waveform and the prototype waveform. An effective power transfer ratio was calculated of the two waveforms and the prototype waveform showed a 80% effective power transfer increase over the traditional waveform. Insight has also been gained into how DC resistance measurements can be performed after epidermal electrical excitation.
Single and Multi‐Mode Directional Lasing from Arrays of Dielectric Nanoresonators (2021)

Abstract The strong electric and magnetic resonances in dielectric subwavelength structures have enabled unique opportunities for efficient manipulation of light–matter interactions. Besides, the dramatic enhancement of nonlinear light–matter interactions near so‐called bound states in the continuum (BICs) has recently attracted enormous attention due to potential advancements. However, the experimental realizations and the applications of high‐Q factor resonances in dielectric resonances in the visible have thus far been considerably limited. In this work, the interplay of electric and magnetic dipoles in arrays of dielectric nanoresonators is explored. The experimental realization of high‐Q factor resonances in the visible through the collective diffractive coupling of electric and magnetic dipoles is reported. It is also shown that coupling the Rayleigh anomaly of the array with the dipoles of the individual nanoresonators can result in the formation of different types of BICs. The resonances in the visible regime is utilized to achieve lasing action at room temperature with high spatial directionality and low threshold. Finally, multi‐mode, directional lasing is experimentally demonstrated and the BIC‐assisted lasing mode engineering in arrays of dielectric nanoresonators is studied. It is believed that the results enable a new range of applications in flat photonics through realizing on‐chip controllable single and multi‐wavelength micro‐lasers.
Large Signal Performance of Tweeters, Micro Speakers and Horn Drivers (2005)

Loudspeaker dedicated to high-frequency signals may also produce significant distortion in the acoustical output. The nonlinearities in motor and suspension can be modelled by equivalent circuits and dynamically measured by system identification technique based voltage and current monitoring. The identified model is the basis for numerical prediction of the large signal performance and reveals the effect of each nonlinearity. The paper uses this technique for the diagnosis of three different drivers, compares measured and predicted distortion, investigates the thermal power compression and discusses the impact on the perceived sound quality.
Evaluation of Wind Erosion Emissions Factors for Air Quality Modeling (2011)

The exposure to airborne particulates and surface deposition are important pathways for many human health assessments. Our primary focus is on air quality modeling issues associated with the emission of airborne particulates from contaminated surfaces via wind erosion and the subsequent deposition onto other areas. In this context, the analysis is directed at long‐term impacts associated with wind‐erosion‐induced movement from a contaminated area onto residential and other property. For this type of application, detailed inputs on soil moisture, armoring, and other factors are typically not known as a function of time. The defined scope and data limitations generally render more detailed and data‐intensive approaches impractical compared with more simplified empirical models. We compare and contrast selected empirical models to show the central tendency as a function of the type of applications (flat–regional and flat–local) as examples. This review demonstrates the importance of applying empirical wind erosion equations in a manner that is consistent with their development and with due consideration of site‐specific features and the specific air quality analysis under evaluation. Of importance to this review are: the scale of analysis, flat vs. pile (elevated) sources, and an appropriate representation of uncertainty. Without consideration of such factors within dispersion modeling analyses of airborne particulate concentrations or surface deposition rates, the exposure analysis can be substantially biased.
Wide-Speed Direct Torque and Flux Control for Interior PM Synchronous Motors Operating at Voltage and Current Limits (2012)

This paper proposes a wide-speed direct torque and flux control method associated with the inverter voltage and current constraints of interior permanent-magnet synchronous motors. The proposed approach has potential advantages controlling torque and flux linkage at the voltage and current limits, since no integrators are employed for torque control or flux weakening. The transition between the non-limited operation and maximum voltage modulation can be achieved automatically without modifying the control law. To confirm this, we provide a graphical and analytical analysis that naturally leads to a unique stator voltage vector selection on the hexagon. The proposed controller can maximize the available inverter voltage and generate a higher output torque than conventional current vector controllers at high speeds. The method developed in this paper also retains the beneficial features of classical direct torque control, such as its fast dynamics and direct manipulation of the stator flux linkage for flux weakening.
Developing a LTE Localization Framework using Real Network Data towards RAN Optimization through Context Knowledge (2020)

The exponential growth of the network elements and data traffic exchange in the last few years elevated the need of network providers for optimized and cost-efficient solutions regarding network management and monitorization. Solutions such as drive-tests (DTs) are becoming extremely expensive with the vast extension and complexity of nowadays mobile networks. Therefore, this paper provides a solution for optimized networkcontext knowledge acquisition, towards the self-organizing networks (SONs) concept. The presented framework incorporates an entire scheme for network Traces processing and positioning, based on network measurements and fingerprinting techniques. This framework enables a series of different use cases for network management and optimization, with real-time data processing capabilities within the network Traces collection interval (15 minutes), and achieving a median positioning error of 90 m.
ChemInform Abstract: Donor‐Acceptor‐Substituted Anions and Cations in the Cyclopentadienyl System. (1986)

Abstract The cyclopentadiene (IV) can be converted both to the fulvenes (X) and to the antiaromatic and aromatic systems (XI) and (XII).
Quantitative Nanoscale Imaging of Lattice Distortions in Epitaxial Semiconductor Heterostructures Using Nanofocused X-ray Bragg Projection Ptychography (2012)

We imaged nanoscale lattice strain in a multilayer semiconductor device prototype with a new X-ray technique, nanofocused Bragg projection ptychography. Applying this technique to the epitaxial stressor layer of a SiGe-on-SOI structure, we measured the internal lattice behavior in a targeted region of a single device and demonstrated that its internal strain profile consisted of two competing lattice distortions. These results provide the strongest nondestructive test to date of continuum modeling predictions of nanoscale strain distributions.
Dynamic selection of a feature-rich query frame for mobile video retrieval (2010)

In this paper, we focus on a new application of mobile visual search: snapping a photo with a mobile device of a video playing on a TV screen to automatically retrieve and stream the remainder of the video to the mobile device. When the user takes a photo of the video, the captured query frame may contain too few useful features for good retrieval performance. We design and implement a new algorithm for mobile video retrieval to accurately select a feature-rich frame from a sequence of viewfinder frames in a very short temporal window determined by the user-initiated query event. Fast and accurate selection using efficiently computed Hessian scores is developed for real-time operation on mobile devices. Viewfinder frames captured before the query starts are pre-processed, while the number of viewfinder frames captured afterwards is minimized by a probabilistic optimization process. Evaluated on a large video database of 10 million frames, dynamic query frame selection provides a substantial increase in retrieval accuracy with very low search latency.
Regulatory mechanisms in breast cancer. Advances in cellular and molecular biology of breast cancer. (1991)

I. Oncogenes, antioncogenes, and tumor prognosis.- 1. Oncogenes as clinical prognostic indicators.- 2. Role of the retinoblastoma gene in the oncogenesis of human breast carcinoma.- II. Growth factors and their receptors.- 3. Relationship of growth factors and differentiation in normal and neoplastic development of the mammary gland.- 4. Local effects of growth factors.- 5. The insulin-like growth factors, their receptors, and their binding proteins in human breast cancer.- 6. The role of ras gene expression and transforming growth factor ? production in the etiology and progression of rodent and human breast cancer.- 7. The role of epidermal growth factor receptors in breast cancer.- 8. Cell proliferation in metazoans: Negative control mechanisms.- III. Estrogen and antiestrogens.- 9. Steroid modulation of the expression of growth factors and oncogenes in breast cancer.- 10. Antiestrogen therapy for breast cancer: Current strategies and potential causes for therapeutic failure.- 11. Steroidal pure antiestrogens.- 12. Estrogen-regulated messenger RNAs in human breast cancer cells.- 13. Estrogen and progesterone receptors.- 14. Growth factors as mediators of estrogen/antiestrogen action in human breast cancer cells.- 15. Steroids, growth factors, and cell cycle controls in breast cancer.- IV. Stromal-epithelial interactions and metastases.- 16. Stromal regulation of epithelial function.- 17. Mammary epithelial cells, extracellular matrix, and gene expression.- 18. Tenascin in mammary gland development: From embryogenesis to carcinogenesis.- 19. Stromal-epithelial interactions in normal and neoplastic mammary gland.- 20. Extracellular matrix metalloproteinases in tumor invasion and metastasis.
High-average-power mid-infrared ZnGeP_2 optical parametric oscillator with a wavelength-dependent polarization rotator (2006)

A wavelength-dependent polarization rotator is used to transform the orthogonal polarizations of the signal and idler of a near-degenerate type II KTP optical parametric oscillator (OPO) into a common polarization state. This common polarization allows a single ZnGeP2 OPO to fully utilize the 2 microm signal and idler KTP OPO outputs in a mid-IR conversion. The simple design of the wavelength-dependent polarization rotator yields a compact source that simultaneously generates four mid-JR wavelengths collinearly with a total mid-IR average power of 5.5 W at a >15 kHz pulse repetition rate.
Delivering ICT infrastructure for biomedical research (2012)

This paper describes an implementation of the Infrastructure-as-a-Service (IaaS) concept for scientific computing and seven service pilot implementations with requirements from biomedical use cases at the CSC - IT Center for Science. The key service design requirements were enabling the use of any scientific software environment the use cases needed to succeed, and delivering the distributed infrastructure ICT resources seamlessly with the local ICT resources for the scientist users. The service concept targets the IT administrators at research organisations and delivers virtualised compute cluster and storage capacity via private network solutions. The virtualised resources can become part of the local cluster as virtual nodes and they can share the same file system as the physical nodes assuming the network performance is sufficient. Extension of the local resources can then be made transparent to enable an easy infrastructure uptake to the scientist end-users. Based on 20 months of service piloting most of the biomedical organisations express a sustained and growing need for the distributed compute and storage resources delivered with the IaaS. We conclude that a successful implementation of the IaaS can improve access and reduce the effort to run expensive ICT infrastructure needed for biomedical research.
Complications of the Prone Transpsoas Lateral Lumbar Interbody Fusion for Degenerative Lumbar Spine Disease: A Multicenter Study (2023)

In this multicenter case series, the PTP approach was well tolerated and associated with a satisfactory safety profile.