gebhart/patrepeval huggingface dataset:
Monocyte-Related Functions Expressed in Cell Lines Established from Human Pancreatic Adenocarcinoma. I. Comparative Analysis of Endocytotic Activity, Lysosomal Enzyme Secretion, and Superoxide Anion Production (1987)

Fine structural analyses of human pancreatic carcinoma have demonstrated their composition of one major cell type, a mucin secreting cell. In lower grades of differentiation the tumor cells change polarity and reduce mucin production and secretion. Instead numerous small vesicles in the cytoplasm and a high frequency of coated pits and coated vesicles beneath the plasma membrane suggest endocytotic activity. One monoclonal antibody (BW 227/19) produced against pancreatic tumor cells of low differentiation, besides binding to primary pancreatic carcinoma in cytofluorometric studies, also reacted with 80% blood monocytes and with macrophages in a variety of tissues, indicating common antigenic determinants on both cell types. Therefore, monocyte-related functions--endocytosis, lysosomal enzyme secretion, and superoxide anion production--were measured in 5 cell lines of pancreatic carcinomas (two lines established from adenocarcinoma of the colon, two lines from small lung cell carcinomas, and one line from squamous cell carcinoma of the lung). These functions were measured under basal conditions and after exposure to zymosan or immune complexes and were compared to isolated normal monocytes of the human. Endocytotic activity, as measured by the uptake of radiolabeled colloidal gold in 4 out of 5 pancreatic tumor cell lines, showed 50% of the basal activity of monocytes, while other tumor cells had only 20% of this activity. Only pancreatic tumor cells demonstrated increased endocytotic, secretory, and chemiluminescence activity to a similar extent as human monocytes after exposure to zymosan or immune complexes. Fine structural studies using cationized ferritin demonstrated the regular endocytotic pathway with uptake via coated pits and vesicles into endosomes and their transfer to a membrane compartment associated with the Golgi complex. The findings indicate a striking similarity between pancreatic tumor cells in vitro and human monocytes, which could be of importance in the understanding of the biology of these ill-defined tumor cells.
Immunoreactive Precipitation of C1 Inhibitor Protein from Plasma of Normal Subjects and of Patients with Hereditary Angioedema after Isoelectric Focusing (1986)

C1-inhibitor is an acid glycoprotein, isoelectric point 3.5-3.6. Plasma of some patients with a variant form of hereditary angioedema contains high levels of functionless C1-inhibitor-albumin complex with an isoelectric point at 4.5-4.6. Therapy with Danazol, which increases C1-inhibitor levels, does not modify the isoelectric focusing pattern of such protein in patients with hereditary angioedema.
HyperCube: A Small Lensless Position Sensing Device for the Tracking of Flickering Infrared LEDs (2015)

An innovative insect-based visual sensor is designed to perform active marker tracking. Without any optics and a field-of-view of about 60°, a novel miniature visual sensor is able to locate flickering markers (LEDs) with an accuracy much greater than the one dictated by the pixel pitch. With a size of only 1 cm3 and a mass of only 0.33 g, the lensless sensor, called HyperCube, is dedicated to 3D motion tracking and fits perfectly with the drastic constraints imposed by micro-aerial vehicles. Only three photosensors are placed on each side of the cubic configuration of the sensing device, making this sensor very inexpensive and light. HyperCube provides the azimuth and elevation of infrared LEDs flickering at a high frequency (>1 kHz) with a precision of 0.5°. The minimalistic design in terms of small size, low mass and low power consumption of this visual sensor makes it suitable for many applications in the field of the cooperative flight of unmanned aerial vehicles and, more generally, robotic applications requiring active beacons. Experimental results show that HyperCube provides useful angular measurements that can be used to estimate the relative position between the sensor and the flickering infrared markers.
In VitroAssessment of Dose Delivery Performance of Dry Powders for Inhalation (2014)

The aerosol performance of engineered porous particles (PulmoSphere™) for inhalation as a function of powder properties (particle size and density) was assessed using an idealized replica of the adult human upper respiratory tract (URT) known as the Alberta mouth-throat model. Engineered placebo powders were prepared using the PulmoSphere™ technology, which is based on spray-drying an emulsion feedstock and produces porous particles with well-controlled size and density. These placebo powders are useful surrogates for a class of potent active formulations, and covered a range of particle sizes and densities, representing a particle design space relevant to dry powder inhalers. The Alberta idealized mouth-throat model was used for in vitro measurement of oropharyngeal (mouth and throat) losses and to estimate the total lung dose for different inhalation drug products. The in vitro lung doses measured with the mouth-throat model were compared to predictions of lung dose from semi-empirical numerical models of oropharyngeal deposition. Data from the mouth-throat model and numerical models were used to rank order oropharyngeal losses and flow-rate dependence in the 1–6 kPa pressure drop range. Aerosol performance of the PulmoSphere™ powders was favored by low-particle density and large geometric size, with the oropharyngeal deposition and flow rate dependence being lower for powders with median particle diameter ≥2.5 microns. In comparison, data from lactose-blend formulations showed significantly higher oropharyngeal deposition and flow rate dependence. The idealized mouth-throat model provides a reasonable in vitro estimate of dose delivered to the lungs, and is a useful tool for studying the effect of factors such as drug/device and inhalation airflow.Copyright 2014 American Association for Aerosol Research
Mechanism of cytochrome P-450 inhibition by cyclopropylamines (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanism of cytochrome P-450 inhibition by cyclopropylaminesTimothy L. Macdonald, Karimullah Zirvi, Leo T. Burka, Pamela Peyman, and F. Peter GuengerichCite this: J. Am. Chem. Soc. 1982, 104, 7, 2050–2052Publication Date (Print):April 1, 1982Publication History Published online1 May 2002Published inissue 1 April 1982https://pubs.acs.org/doi/10.1021/ja00371a056https://doi.org/10.1021/ja00371a056research-articleACS PublicationsRequest reuse permissionsArticle Views345Altmetric-Citations130LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis of 3-Allenylindoles and 3-Dienylindoles by Brønsted Acid Catalyzed Allenylation of 2-Arylindoles with Tertiary Propargylic Alcohols (2009)

The Brønsted acid catalyzed direct nucleophilic substitution of tertiary propargylic alcohols with 2-aryl-substituted indoles has been studied. A competitive allenylation process takes place with appropriate substituents on the alkynol moiety. Starting from 2-arylindoles, new 3-allenyl and 3-dienylindole derivatives have been easily synthesized.
Changes in Collagen Metabolism in Diseased Muscle (1982)

Immunofluorescence studies using specific antibodies against collagen of types I, III, IV, and V were carried out on muscle biopsy specimens from 22 patients with various neuromuscular disorders and seven controls. Increased staining with all antibodies was seen in the patients with polymyositis and muscular dystrophy. Increased staining with types I and III antibodies was found in the samples from the patients with amyotrophic lateral sclerosis in cases with an elevated concentration of muscular hydroxyproline. Two patients with amyotrophic lateral sclerosis showed no accumulation of collagen, and this was similarly true of the polyneuropathy cases. An accumulation of types IV and V collagen was typical for the myotonia congenita samples. The immunohistochemical results were in good agreement with the biochemical findings from the same patients.
Stroboscopic fluorescence lifetime imaging (2009)

We report a fluorescence lifetime imaging technique that uses the time integrated response to a periodic optical excitation, eliminating the need for time resolution in detection. A Dirac pulse train of variable period is used to probe the frequency response of the total fluorescence per pulse leading to a frequency roll-off that is dependent on the relaxation rate of the fluorophores. The technique is validated by demonstrating wide-field, realtime, lifetime imaging of the endocytosis of inorganic quantum dots by a cancer cell line. Surface charging of the dots in the intra-cellular environment produces a switch in the fluorescence lifetime from approximately 40 ns to < 10 ns. A temporal resolution of half the excitation period is possible which in this instance is 15 ns. This stroboscopic technique offers lifetime based imaging at video rates with standard CCD cameras and has application in probing millisecond cell dynamics and in high throughput imaging assays.
Deployment of the Burkholderia glumae type III secretion system as an efficient tool for translocating pathogen effectors to monocot cells (2013)

Genome sequences of plant fungal pathogens have enabled the identification of effectors that cooperatively modulate the cellular environment for successful fungal growth and suppress host defense. Identification and characterization of novel effector proteins are crucial for understanding pathogen virulence and host-plant defense mechanisms. Previous reports indicate that the Pseudomonas syringae pv. tomato DC3000 type III secretion system (T3SS) can be used to study how non-bacterial effectors manipulate dicot plant cell function using the effector detector vector (pEDV) system. Here we report a pEDV-based effector delivery system in which the T3SS of Burkholderia glumae, an emerging rice pathogen, is used to translocate the AVR-Pik and AVR-Pii effectors of the fungal pathogen Magnaporthe oryzae to rice cytoplasm. The translocated AVR-Pik and AVR-Pii showed avirulence activity when tested in rice cultivars containing the cognate R genes. AVR-Pik reduced and delayed the hypersensitive response triggered by B. glumae in the non-host plant Nicotiana benthamiana, indicative of an immunosuppressive virulence activity. AVR proteins fused with fluorescent protein and nuclear localization signal were delivered by B. glumae T3SS and observed in the nuclei of infected cells in rice, wheat, barley and N. benthamiana. Our bacterial T3SS-enabled eukaryotic effector delivery and subcellular localization assays provide a useful method for identifying and studying effector functions in monocot plants.
Reactive Polymer Based Colloids for Biomedical Applications (2005)

Abstract Summary: This short review aimed to give to the reader brief applications of polymer colloids in biomedical area and principally in medical diagnostics. Colloidal polymer particles are mainly used as solid supports, as label for biomolecules reactions detection, and as a carrier. The elaboration of appropriate colloids is reached via numerous processes such as polymerization in dispersed media (dispersion, emulsion, precipitation, miniemulsion polymerizations) or as physico‐chemical methodologies (i.e., self‐assembly). After a short introduction, some particles elaborations are presented and their applications are briefly described and illustrated.
Experimental Characterization of Plasmonic Modes in a Multimode Metal-Insulator-Metal Waveguide by Attenuated Total Reflection (2011)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text C. Lin and T. K. Gaylord, "Experimental Characterization of Plasmonic Modes in a Multimode Metal-Insulator-Metal Waveguide by Attenuated Total Reflection," in Frontiers in Optics 2011/Laser Science XXVII, OSA Technical Digest (Optica Publishing Group, 2011), paper FWC6. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
PoseNet3D: Learning Temporally Consistent 3D Human Pose via Knowledge\n Distillation (2020)

Recovering 3D human pose from 2D joints is a highly unconstrained problem. We\npropose a novel neural network framework, PoseNet3D, that takes 2D joints as\ninput and outputs 3D skeletons and SMPL body model parameters. By casting our\nlearning approach in a student-teacher framework, we avoid using any 3D data\nsuch as paired/unpaired 3D data, motion capture sequences, depth images or\nmulti-view images during training. We first train a teacher network that\noutputs 3D skeletons, using only 2D poses for training. The teacher network\ndistills its knowledge to a student network that predicts 3D pose in SMPL\nrepresentation. Finally, both the teacher and the student networks are jointly\nfine-tuned in an end-to-end manner using temporal, self-consistency and\nadversarial losses, improving the accuracy of each individual network. Results\non Human3.6M dataset for 3D human pose estimation demonstrate that our approach\nreduces the 3D joint prediction error by 18% compared to previous unsupervised\nmethods. Qualitative results on in-the-wild datasets show that the recovered 3D\nposes and meshes are natural, realistic, and flow smoothly over consecutive\nframes.\n
Effect of varying polymer matrices and gases on the singlet and triplet behavior of 2-piperidinoanthraquinone (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of varying polymer matrices and gases on the singlet and triplet behavior of 2-piperidinoanthraquinoneL. V. Natarajan and Ralph S. BeckerCite this: Macromolecules 1988, 21, 1, 73–78Publication Date (Print):January 1, 1988Publication History Published online1 May 2002Published inissue 1 January 1988https://pubs.acs.org/doi/10.1021/ma00179a016https://doi.org/10.1021/ma00179a016research-articleACS PublicationsRequest reuse permissionsArticle Views45Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Figures S1 and S2 from X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis (2023)

&lt;p&gt;Location of Mutations in KDM6A and KDM5C&lt;/p&gt;
Characterization of the Fluid Deaeration Device for a Hydraulic Hybrid Vehicle System (2008)

&lt;div class="htmlview paragraph"&gt;The attractiveness of the hydraulic hybrid concept stems from the high power density and efficiency of the pump/motors and the accumulator. This is particularly advantageous in applications to heavy vehicles, as high mass translates into high rates of energy flows through the system. Using dry case hydraulic pumps further improves the energy conversion in the system, as they have 1-4% better efficiency than traditional wet-case pumps. However, evacuation of fluid from the case introduces air bubbles and it becomes imperative to address the deaeration problems. This research develops a bubble elimination efficiency testing apparatus (BEETA) to establish quantitative results characterizing bubble removal from hydraulic fluid in a cyclone deaeration device. The BEETA system mixes the oil and air according to predetermined ratio, passes the mixture through a cyclone deaeration device, and then measures the concentration of air in the exiting fluid. Test results indicate the ability of the cyclone deaeration device to remove large bubbles with near 100% efficiency, while elimination of small (less than 1 mm diameter) bubbles proved to be a challenge. The explanation is provided through application of Stokes Law that shows a strong relationship between bubble size and bubble rise velocity. The theoretical analysis provides clear guidance regarding pathways towards improving the effectiveness of removing small bubbles.&lt;/div&gt;
Global Capacity Measures for Deep ReLU Networks via Path Sampling (2019)

Classical results on the statistical complexity of linear models have commonly identified the norm of the weights $\|w\|$ as a fundamental capacity measure. Generalizations of this measure to the setting of deep networks have been varied, though a frequently identified quantity is the product of weight norms of each layer. In this work, we show that for a large class of networks possessing a positive homogeneity property, similar bounds may be obtained instead in terms of the norm of the product of weights. Our proof technique generalizes a recently proposed sampling argument, which allows us to demonstrate the existence of sparse approximants of positive homogeneous networks. This yields covering number bounds, which can be converted to generalization bounds for multi-class classification that are comparable to, and in certain cases improve upon, existing results in the literature. Finally, we investigate our sampling procedure empirically, which yields results consistent with our theory.
LISA system design highlights (2009)

A contract, started in January 2005, was awarded to a consortium of Astrium GmbH and Astrium Ltd for the LISA Mission Formulation. The scope of the contract was the development of a reference design for the mission architecture and for the mission elements (with particular focus on the payload) and a successive phase of derivation of requirements, to be concluded with a mission design review. The technical starting point was the output of the previous LISA study formalized in the Final Technical Report, issued in the year 2000. During the design phase, different architecture concepts were identified and traded off, including the LISA orbits, the measurement scheme and the opto-mechanical architecture. During the Mission Design Review (July 2008) the consolidated mission baseline design, and the specifications of the flight elements and of the payload subsystem and major components were presented. This paper gives a brief overview of the major design points of the latest design of the LISA system.
Tutorial review—Multi-electrode array detectors in high-performance liquid chromatography: a new dimension in electrochemical analysis (1993)

Liquid chromatography has been evolving rapidly over recent years and now provides a fast, accurate and reliable method for determining the identity and concentration of a wide range of compounds. Recent advances in detector systems include the introduction of a multi-electrode high efficiency electrochemical sensor, which enables compounds to be resolved as a function of their individual oxidation potential. Combining such array sensors with gradient chromatography increases both the range of compounds in samples that can be identified in a short period of time and the confidence with which they can be matched to known standards. This paper introduces the field of three-dimensional chromatography using electrochemical array detectors and provides examples of where this new technology is currently being used.
Cu(InGa)Se2 photovoltaics on insulated Stainless Steel Web substrate (2010)

This paper presents data on the use of Stainless Steel (SS) foils, coated with 3 to 5μm silicone based resin (SBR) developed by Dow Corning Corporation (DCC) for Cu(InGa)Se <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> based PV devices. The substrate validation was performed by the device performances on R2R deposited Cu(InGa)Se <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> via elemental evaporation and, to a limited extent, on Cu(InGa)Se <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> films from metal precursor selenization. Initially, it is shown that a 430SS base is preferred to others due to a better thermal expansion match to Cu(InGa)Se <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> . The SBR-coated SS was found to be an excellent substrate in terms of (i) the adhesion of Mo and Cu(InGa)Se <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> films, (ii) its surface smoothness, and (iii) its operational stability up to 600 °C. Na was introduced into the R2R deposition process by co-evaporating NaF during deposition. Presence of Na in the films was determined by SIMS depth profiling. The highest small area device performance from R2R deposition was 15.2%. In addition, 9ft and 29ft long 8" wide Cu(InGa)Se <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> webs fabricated in the reactor showed machine direction center line, and efficiencies that averaged more than 10%. Precursor selenization process gave the highest efficiency of 12.3% with 10nm NaF deposited on the SBR or on the precursors. Work on developing monolithically integrated 3"×3" mini-modules has been initiated. Encouraging results were obtained in laser scribing the Mo back contact.