gebhart/patrepeval huggingface dataset:
A STUDY ON GRASP OF SPATIAL CHARACTERISTIC WITH VISUALIZING THE ACTIVITY VECTOR FIELD (2007)

Even though there are new approaches to create space has been discussing among outstanding architects recently, the basic method to grasp the relationship between human behavior and space remains an exisiting style. This paper investigates three featured spaces to draw the activity vector field from movement of people to explore the concept of the function of space or spacial charateristic. The findings are followings; The activities caused a program influenced surrounding space in new universal space but in ordinary space did not. We develop a new method to draw the activity vector field based on probability of each movement. With the method we succeed to grasp a couple of act, which might express the redundancy of space.
Abstract 1503: PSMA Aptamer-targeted siRNAs selectively Eehance prostate cancer radiation sensitivity (2010)

Abstract The application of dose escalated radiation therapy for localized prostate cancer has a clear therapeutic benefit; however, its clinical use is hampered by the increased risk of damage to surrounding normal tissues. One attractive alternative to elevated doses is radiation sensitizing agents. Prostate cancer cells can be made radiosensitive by targeted reductions of DNA repair proteins via RNA interference. However, without tissue-selective targeting, these agents will also sensitize surrounding tissue, leading to increased adverse effects. Here we describe a strategy where prostate-targeted RNA interference is used to selectively radio-sensitize prostate cancer cells. A high throughput siRNA screen was completed to identify DNA-repair pathway targets for prostate cancer radio-sensitization. Candidate siRNAs were then conjugated to PSMA-targeted RNA aptamers for selective delivery of siRNAs to Prostate cancer cells. In vitro and in vivo data support PSMA and aptamer-specific targeting and gene knock-down. These studies support continued development of this technology as a path to enhance radiotherapeutic outcomes for men with Prostate cancer and it is the first report of targeted, prostate-specific siRNAs for radio-sensitization. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1503.
Comparing Populations of Western Corn Rootworm (Coleoptera: Chrysomelidae) in Regions With and Without a History of Injury to Cry3 Corn (2020)

Transgenic corn expressing insecticidal proteins derived from the bacterium Bacillus thuringiensis (Bt) is an important pest management tool. Western corn rootworm, Diabrotica virgifera virgifera LeConte, is a key pest of corn in the midwestern United States that has developed field-evolved resistance to all available Bt traits. The first Bt trait to be commercialized for management of rootworm was Cry3Bb1 in 2003, and field-evolved resistance appeared in 2009. In this study, we examined fields in counties where greater-than-expected injury to Cry3 (Cry3Bb1 or mCry3A) corn roots (>1 node) had previously been reported (problem counties) and counties where injury had not been reported (non-problem counties). Four to eight fields were sampled per county in 2015, 2016, and 2017 to quantify rootworm abundance, root injury, Cry3Bb1resistance, and rootworm management strategies. Rootworm abundance, root injury, and resistance to Cry3Bb1 did not differ between county types. Management tactics differed between county types, with problem counties growing more corn, using more soil insecticide, and growing more Cry34/35Ab1 corn. Additionally, a comparison of root injury to Bt and non-Bt corn within fields indicated that farmers derived an economic benefit from planting Bt corn to manage corn rootworm. Our results suggest that rootworm populations are similar between problem and non-problem counties in Iowa due to similar levels of selection pressure on Cry3 corn, but problem county fields have applied more management tactics due to previous rootworm issues in the area.
Dielectric and Piezoelectric Properties of Barium-substituted Sr1.9Ca0.1NaNb5O15Ceramics (2003)

Highly dense piezoelectric ceramics of tungsten bronze-type (Sr1.9Ca0.1)1-0.5xBaxNaNb5O15 (where x=0.1–0.8) were prepared by spark plasma sintering. The crystallographic parameters, dielectric behaviors and piezoelectric properties of the sintered ceramics were investigated, and the effects of the Ba substitution on these electrical properties were discussed. The structural analysis and the electrical property measurements indicate a morphotropic phase boundary (MPB)-like phenomenon at x=0.4–0.5. In all compositions, a diffuse phase transition and a relaxor behavior are observed. The electrical properties are found to be crystallographically dependent.
Genetic re-engineering of polyunsaturated phospholipid profile of Saccharomyces cerevisiae identifies a novel role for Cld1 in mitigating the effects of cardiolipin peroxidation Molecular and cell biology of lipids (2018)

Cardiolipin (CL) is a unique phospholipid localized almost exclusively within the mitochondrial membranes where it is synthesized. Newly synthesized CL undergoes acyl remodeling to produce CL species enriched with unsaturated acyl groups. Cld1 is the only identified CL-specific phospholipase in yeast and is required to initiate the CL remodeling pathway. In higher eukaryotes, peroxidation of CL, yielding CLOX, has been implicated in the cellular signaling events that initiate apoptosis. CLOX can undergo enzymatic hydrolysis, resulting in the release of lipid mediators with signaling properties. Our previous findings suggested that CLD1 expression is upregulated in response to oxidative stress, and that one of the physiological roles of CL remodeling is to remove peroxidized CL. To exploit the powerful yeast model to study functions of CLD1 in CL peroxidation, we expressed the H. brasiliensis Δ¹²-desaturase gene in yeast, which then synthesized poly unsaturated fatty acids(PUFAs) that are incorporated into CL species. Using LC-MS based redox phospholipidomics, we identified and quantified the molecular species of CL and other phospholipids in cld1Δ vs. WT cells. Loss of CLD1 led to a dramatic decrease in chronological lifespan, mitochondrial membrane potential, and respiratory capacity; it also resulted in increased levels of mono-hydroperoxy-CLs, particularly among the highly unsaturated CL species, including tetralinoleoyl-CL. In addition, purified Cld1 exhibited a higher affinity for CLOX, and treatment of cells with H2O2 increased CLD1 expression in the logarithmic growth phase. These data suggest that CLD1 expression is required to mitigate oxidative stress. The findings from this study contribute to our overall understanding of CL remodeling and its role in mitigating oxidative stress.
Method for in situ characterization of radiofrequency heating in parallel transmit MRI (2012)

In ultra-high-field magnetic resonance imaging, parallel radiofrequency (RF) transmission presents both opportunities and challenges for specific absorption rate management. On one hand, parallel transmission provides flexibility in tailoring electric fields in the body while facilitating magnetization profile control. On the other hand, it increases the complexity of energy deposition as well as possibly exacerbating local specific absorption rate by improper design or delivery of RF pulses. This study shows that the information needed to characterize RF heating in parallel transmission is contained within a local power correlation matrix. Building upon a calibration scheme involving a finite number of magnetic resonance thermometry measurements, this work establishes a way of estimating the local power correlation matrix. Determination of this matrix allows prediction of temperature change for an arbitrary parallel transmit RF pulse. In the case of a three transmit coil MR experiment in a phantom, determination and validation of the power correlation matrix were conducted in less than 200 min with induced temperature changes of <4°C. Further optimization and adaptation are possible, and simulations evaluating potential feasibility for in vivo use are presented. The method allows general characteristics indicative of RF coil/pulse safety determined in situ.
Fluxed animated boundary method (2017)

We present a novel approach to guiding physically based particle simulations using boundary conditions. Unlike commonly used ad hoc particle techniques for adding and removing the material from a simulation, our approach is principled by utilizing the concept of volumetric flux. Artists are provided with a simple yet powerful primitive called a fluxed animated boundary (FAB) , allowing them to specify a control shape and a material flow field. The system takes care of enforcing the corresponding boundary conditions and necessary particle reseeding. We show how FABs can be used artistically or physically. Finally, we demonstrate production examples that show the efficacy of our method.
Effect of Cage Size on the Selective Conversion of Methanol to Light Olefins (2012)

Zeolites that contain eight-membered ring pores but different cavity geometries (LEV, CHA, and AFX structure types) are synthesized at similar Si/Al ratios and crystal sizes. These materials are tested as catalysts for the selective conversion of methanol to light olefins. At 400 °C, atmospheric pressure, and 100% conversion of methanol, the ethylene selectivity decreases as the cage size increases. Variations in the Si/Al ratio of the LEV and CHA show that the maximum selectivity occurs at Si/Al = 15–18. Because lower Si/Al ratios tend to produce faster deactivation rates and poorer selectivities, reactivity comparisons between frameworks are performed with solids having a ratio Si/Al = 15–18. With LEV and AFX, the data are the first from materials with this high Si/Al. At similar Si/Al and primary crystallite size, the propylene selectivity for the material with the CHA structure exceeds those from either the LEV or AFX structure. The AFX material gives the shortest reaction lifetime, but has the lowest amount of carbonaceous residue after reaction. Thus, there appears to be an intermediate cage size for maximizing the production of light olefins and propylene selectivities equivalent to or exceeding ethylene selectivities.
Investigation Activity and Data on Safety of Liquid Crystal Materials (2001)

Abstract The safety data of the 76 liquid crystal components with CN-group, which were officially excluded from the list of ‘deleterious substances’ are discussed. The acute toxicity of the 496 liquid crystal components without CN-group being used in the market and classified according the terminal groups and the linkages are shown. The statement on the safety of the liquid crystal materials by the three liquid crystal material suppliers is made.
957 THE CLINICAL SIGNIFICANCE OF PLASMA OSTEOPONTIN LEVEL IN EGYPTIAN PATIENTS WITH HEPATITIS C VIRUS-RELATED HEPATOCELLULAR CARCINOMA (2011)

results being statistically significant (P 20mm: 96% vs. 87%, respectively). Conclusions: Hepatocyte-specific Gd-EOB-DTPA enhanced MRI has sufficient image quality to detect HCC lesions diagnosed by CT-HA and CT-AP. Hepatocyte-phase is especially useful for the detection for smaller lesions.
Abstract 210: Cul4A is an oncogene in malignant pleural mesothelioma (2012)

Abstract Cullin 4A (Cul4A) is important in cell survival, development, growth and the cell cycle, but its role in mesothelioma has not been studied. For the first time, we identified amplification of the Cul4A gene in four of five mesothelioma cell lines. Consistent with increased Cul4A gene copy number, we found that Cul4A protein was overexpressed in mesothelioma cells as well. Cul4A protein was also overexpressed in 64% of primary malignant pleural mesothelioma (MPM) tumours. Furthermore, knockdown of Cul4A with shRNA in mesothelioma cells resulted in up-regulation of p21 and p27 tumour suppressor proteins in a p53-independent manner in H290, H28 and MS-1 mesothelioma cell lines. Knockdown of Cul4A also resulted in G0/G1 cell cycle arrest and decreased colony formation in H290, H28 and MS-1 mesothelioma cell lines. Moreover, G0/G1 cell cycle arrest was partially reversed by siRNA down-regulation of p21 and/or p27 in Cul4A knockdown H290 cell line. In the contrary, overexpression of Cul4A resulted in down-regulation of p21 and p27 proteins and increased colony formation in H28 mesothelioma cell line. Both p21 and p27 showed faster degradation rates in Cul4A overexpressed H28 cell line and slower degradation rates in Cul4A knockdown H28 cell line. Our study indicates that Cul4A amplification and overexpression play an oncogenic role in the pathogenesis of mesothelioma. Thus, Cul4A may be a potential therapeutic target for malignant pleural mesothelioma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 210. doi:1538-7445.AM2012-210
Nonlinear mode interaction and slow/fast light generation in semiconductor lasers (2006)

Nonlinear interactions between optical modes in semiconductor lasers and optical amplifiers perturb optical parameters in the vicinity of a strong mode frequency. This effect is considered in terms of slow and fast light propagation.
A221 Development of High Efficiency Repairing Method using Rectangular Laser Beam and Hot Wire System (2015)

An additional maintenance program is need based on results of re-evaluation for the executed maintenances. Especially, repairing of wider or more complicated shaped area may be repairing targets. Underwater laser welding has been developing as a repairing technique for nuclear power plants. In past study, a new repairing technique combined direct diode laser (DDL), which has rectangular energy distribution, with hot wire feed device were proposed to improve efficiency of welding. This new repairing technique indicated twice efficiency of welding compared to the conventional underwater laser welding. In this study, "Fiber transmission" and "Converting rectangular energy distribution from Gaussian energy distribution by diffractive optical element (DOE)" were considered. As the results of welding tests, DDL configuration indicated the same capability of welding as DOE configuration.
On Reward-Free Reinforcement Learning with Linear Function Approximation (2020)

Reward-free reinforcement learning (RL) is a framework which is suitable for both the batch RL setting and the setting where there are many reward functions of interest. During the exploration phase, an agent collects samples without using a pre-specified reward function. After the exploration phase, a reward function is given, and the agent uses samples collected during the exploration phase to compute a near-optimal policy. Jin et al. [2020] showed that in the tabular setting, the agent only needs to collect polynomial number of samples (in terms of the number states, the number of actions, and the planning horizon) for reward-free RL. However, in practice, the number of states and actions can be large, and thus function approximation schemes are required for generalization. In this work, we give both positive and negative results for reward-free RL with linear function approximation. We give an algorithm for reward-free RL in the linear Markov decision process setting where both the transition and the reward admit linear representations. The sample complexity of our algorithm is polynomial in the feature dimension and the planning horizon, and is completely independent of the number of states and actions. We further give an exponential lower bound for reward-free RL in the setting where only the optimal $Q$-function admits a linear representation. Our results imply several interesting exponential separations on the sample complexity of reward-free RL.
TGF-βI Regulates Cell Migration through Pluripotent Transcription Factor OCT4 in Endometriosis (2015)

&lt;div&gt;&lt;p&gt;Transforming growth factor (TGF-β)/TGF-β receptor signal is known to promote cell migration. Up-regulation of TGF-β in serum/peritoneal fluid and increased levels of pluripotent transcription factor OCT4 in endometriotic tissues are frequently observed in patients with endometriosis. However, the mechanisms underlying how TGF-β/TGF-β receptor and OCT4 affect endometriotic cell migration still remain largely unknown. Therefore, endometriotic tissue with high cell migratory capacity were collected from patients with adenomyotic myometrium (&lt;i&gt;n&lt;/i&gt; = 23) and chocolate cyst (&lt;i&gt;n&lt;/i&gt; = 24); and endometrial tissue with low cell migratory capacity in normal endometrium or hyperplastic endometrium (&lt;i&gt;n&lt;/i&gt; = 8) were collected as the controls. We found the mRNA levels of TGF-β receptor I (&lt;i&gt;TGF-β RI&lt;/i&gt;) and &lt;i&gt;OCT4&lt;/i&gt; were significantly higher in the high-migratory ectopic endometriotic tissues than those of the low-migratory normal or hyperplastic endometrium. Positive correlations between &lt;i&gt;TGF-β RI&lt;/i&gt; and &lt;i&gt;OCT4&lt;/i&gt;, and either &lt;i&gt;TGF-β RI&lt;/i&gt; or &lt;i&gt;OCT4&lt;/i&gt; with migration-related genes (&lt;i&gt;SNAIL&lt;/i&gt;, &lt;i&gt;SLUG&lt;/i&gt; and &lt;i&gt;TWIST&lt;/i&gt;) regarding the mRNA levels were observed in human endometriotic tissues. TGF-βI dose-dependently increased the gene and protein levels of OCT4, SNAIL and N-Cadherin (N-CAD) and silencing of endogenous OCT4 significantly suppressed the TGF-βI-induced expressions of N-CAD and SNAIL in primary human endometriotic stromal cells and human endometrial carcinoma cell lines RL95-2 and HEC1A. Furthermore, TGF-βI significantly increased the migration ability of endometriotic cells and silencing of OCT4 dramatically suppressed the TGF-βI-induced cell migration activity evidenced by wound-closure assay, transwell assay, and confocal image of F-actin cellular distribution. In conclusion, the present findings demonstrate that the niche TGF-β plays a critical role in initiating expressions of pluripotent transcription factor OCT4 which may contribute to the ectopic endometrial growth by stimulating endometrial cell migration. These findings would be useful for developing therapeutic strategies targeting TGF-β-OCT4 signaling to prevent endometriosis in the future.&lt;/p&gt;&lt;/div&gt;
Terminology for aggregation and self-assembly in polymer science (IUPAC Recommendations 2013) (2012)

In the past, aggregation and self-assembly have been associated principally with micellar and colloidal systems of molecules; however, with the advent of supramolecular chemistry, molecular self-assembly has been opened to a much wider understanding that has facilitated access to a variety of different shapes and sizes, along with the construction of new and fascinating molecular topologies. This document aims at defining more than 150 terms related to aggregation and self-assembly in the particular case of macromolecules. The list is restricted to the most commonly encountered terms.
Apoptosis bcl-2 and nitrotyrosine expression in an angioplasty-restenosis rabbit: An experimental model (2007)

Apoptosis has been suggested to have an important role in the pathogenesis of restenosis in addition to cell migration and proliferation. The aim of the present study was to investigate in an experimental in vivo model the occurrence of apoptosis postangioplasty and its relation to bcl-2 and peroxynitrite detection. Eighteen hypercholesterolemic rabbits underwent transluminal angioplasty of the right iliac artery. The rabbits were sacrificed on the 1st, 2nd, 3rd, 7th, 15th, and 28th day postangioplasty (3 animals per time point) and both the angioplasted and non-injured arteries were studied. Apoptosis was assessed by the terminal uridine nick-end labeling method (TUNEL). Bcl-2 and peroxynitrite were detected by immunochemistry using anti-bcl-2 and anti-nitrotyrosine antibodies. In the angioplasted arteries the number of apoptotic cells was <or=1% of the total cell population in both media and neointima at any of the postangioplasty time points examined. Bcl-2 and nitrotyrosines were detected at all time points in the angioplasted arteries (vs. non-injured, P<0.001), showed similar localization and had the same peaks of expression both in the media (7th day: Bcl-2 66% and nitrotyrosines 74%) and neointima (15th day: Bcl-2 67% and nitrotyrosines 61%). In this experimental model we observed low apoptotic rates while bcl-2 and peroxynitrite products were detected. We can hypothesize that the detection of nitrotyrosines is related with reduced levels of nitric oxide resulting in increased expression of the bcl-2, preventing thus cell death due to either apoptosis or necrosis. Further studies are needed in order to elucidate their role in the restenosis process.
Longitudinal maneuvering control for automated highway systems based on a magnetic reference/sensing system (2005)

A reliable estimation algorithm for the absolute velocity of a vehicle has been required in studies by California PATH (Partners for Advanced Transit and Highways) to design stable and robust controller for a vehicle for intelligent vehicle highway systems (IVHS). This paper investigates the feasibility of using magnetic markers, already presented for lateral vehicle guidance in IVHS, for estimating vehicle position and velocity. In this paper, the use of a hybrid observer is proposed. Vehicle longitudinal motion control based on magnetic markers is also considered and evaluated by simulations.
Simulation of specimen‐induced aberrations for objects with spherical and cylindrical symmetry (2004)

Wavefront aberrations caused by the refractive index structure of the specimen are known to compromise signal intensity and three-dimensional resolution in confocal and multiphoton microscopy. However, adaptive optics can measure and correct specimen-induced aberrations. For the design of an adaptive optics system, information on the type and amount of the aberration is required. We have previously described an interferometric set-up capable of measuring specimen-induced aberrations and a method for the extraction of the Zernike mode content. In this paper we have modelled specimen-induced aberrations caused by spherical and cylindrical objects using a ray tracing method. The Zernike mode content of the wavefronts was then extracted from the simulated wavefronts and compared with experimental results. Aberrations for a simple model of an oocyte cell consisting of two spherical regions and for a model of a well-characterized optical fibre are calculated. This simple model gave Zernike mode data that are in good agreement with experimental results.
[Molecular mechanisms of insomnia]. (2009)

Prostaglandin (PG) D2 and adenosine are potent endogenous somnogens and their sleep-inducing mechanisms are well characterized. We examined the contribution of these somnogens to physiological sleep by the combination of pharmacological tools and gene-knockout (KO) mice. Complete insomnia was observed in wild-type mice after an intraperitoneal injection of SeCl4, an inhibitor of PGD synthase (PGDS), or caffeine, an antagonist of adenosine A2A receptors. The SeCl4-induced insomnia was not observed in PGDS- or DP1 receptor-KO mice and the caffeine-induced insomnia, in A(2A) receptor-KO mice. A DP1 antagonist, ONO-4127Na, reduced sleep of rats by 30% during infusion into the subarachnoid space of the basal forebrain. These results indicate that the PGD2/ adenosine system plays a critical role in the regulation of physiological sleep.
Thermal Properties of Li4Ti5O12/LiMn2O4 Battery System (2007)

Abstract not Available.