gebhart/patrepeval huggingface dataset:
Volumetric capnography (2014)

Recent advances in VCap and our improved understanding of its clinical implications may help in overcoming the known limitations and reluctances to include expired CO2 kinetics and dead space analysis in routine bedside monitoring. It is about time to start using this powerful monitoring tool to support decision making in the intensive care environment.
Phosphorylation of annexin II tetramer by protein kinase C inhibits aggregation of lipid vesicles by the protein. (1992)

Annexin II tetramer (A-IIt) is a member of the annexin family of Ca2+ and phospholipid-binding proteins. The ability of this protein to aggregate both phospholipid vesicles and chromaffin granules has suggested a role for the protein in membrane trafficking events such as exocytosis. A-IIt is also a major intracellular substrate of both pp60src and protein kinase C; however, the effect of phosphorylation on the activity of this protein is unknown. In the current report we have examined the effect of phosphorylation on the lipid vesicle aggregation activity of the protein. Protein kinase C catalyzed the incorporation of 2.1 +/- 0.8 mol of phosphate/mol of A-IIt. Phosphorylation of A-IIt caused a dramatic decrease in the rate and extent of lipid vesicle aggregation without significantly effecting Ca(2+)-dependent lipid binding by the phosphorylated protein. Phosphorylation of A-IIt increased the A50%(Ca2+) of lipid vesicle aggregation from 0.18 microM to 0.65 mM. Activation of A-IIt phosphorylation, concomitant with activation of lipid vesicle aggregation, inhibited both the rate and extent of lipid vesicle aggregation but did not cause disassembly of the aggregated lipid vesicles. These results suggest that protein kinase C-dependent phosphorylation of A-IIt blocks the ability of the protein to aggregate phospholipid vesicles without affecting the lipid vesicle binding properties of the protein.
Abstract 14084: Computationally Identified Shape Differences In The Left Atrium On Pre-ablation Ct Scans Appear To Be Associated With Recurrence Of Atrial Fibrillation (2021)

Introduction: Catheter-based ablation is an increasingly utilized management strategy for atrial fibrillation (AF); however, a major problem is AF recurrence post-ablation. There is increasing interest in the use of advanced image analysis to better understand differences in left atrial (LA) shape that may be associated with a higher recurrence risk and potential sites of recurrence. Hypothesis: Factors which lead to the post-ablation recurrence prompt LA differential remodeling. The significant shape difference regions among AF recurrence (AF+) and AF non-recurrence (AF-) patients can be identified from pre-ablation CT scans. Those regions could potentially represent future sites of recurrence and hence could be targets for ablation. Methods: This study included pre-ablation CT-scans of 51 AF+ and 51 AF- patients. Two separate atlases were created by registering Left atrial CT volumes of AF+ and AF- patients to their representative templates (T+ and T- respectively). The atlases were co-registered to a common canonical frame of reference (T-) and a non-parametric General Linear Model (GLM) based t-test with 500 permutations was used to identify the regions (Surface of interest (SOI)) that are statistically significant (p-value&lt;0.1) between the two classes. To reduce sensitivity in the template selection, we constructed an ensemble SOI based on SOIs obtained from 10 different templates and made the frequency map of overlap SOIs. Results: The registration accuracy in the final common frame in terms of average Dice similarity coefficient was in the range of 0.85-0.94 over the 10 SOI constructions. The frequency map revealed the maximum overlap of SOIs in an area where left pulmonary veins enter the left atrium. This could potentially represent a new target for ablation. Conclusions: An ensemble atlas-based shape differentiation method revealed SOI regions that are structurally associated with recurrence and might potentially represent targets for ablation.
Identification of a Chemoreceptor for Tricarboxylic Acid Cycle Intermediates (2010)

We report the identification of McpS as the specific chemoreceptor for 6 tricarboxylic acid (TCA) cycle intermediates and butyrate in Pseudomonas putida. The analysis of the bacterial mutant deficient in mcpS and complementation assays demonstrate that McpS is the only chemoreceptor of TCA cycle intermediates in the strain under study. TCA cycle intermediates are abundantly present in root exudates, and taxis toward these compounds is proposed to facilitate the access to carbon sources. McpS has an unusually large ligand-binding domain (LBD) that is un-annotated in InterPro and is predicted to contain 6 helices. The ligand profile of McpS was determined by isothermal titration calorimetry of purified recombinant LBD (McpS-LBD). McpS recognizes TCA cycle intermediates but does not bind very close structural homologues and derivatives like maleate, aspartate, or tricarballylate. This implies that functional similarity of ligands, such as being part of the same pathway, and not structural similarity is the primary element, which has driven the evolution of receptor specificity. The magnitude of chemotactic responses toward these 7 chemoattractants, as determined by qualitative and quantitative chemotaxis assays, differed largely. Ligands that cause a strong chemotactic response (malate, succinate, and fumarate) were found by differential scanning calorimetry to increase significantly the midpoint of protein unfolding (T(m)) and unfolding enthalpy (DeltaH) of McpS-LBD. Equilibrium sedimentation studies show that malate, the chemoattractant that causes the strongest chemotactic response, stabilizes the dimeric state of McpS-LBD. In this respect clear parallels exist to the Tar receptor and other eukaryotic receptors, which are discussed.
Fluctuation in Lattice Constant near Miscibility Gap of CdTe-Ga2Te3 System (1985)

Appearance of miscibility gaps in solid solution CdTe-Ga 2 Te 3 was describe taking account of fluctuation of lattice constants due to an increasing concentration of Ga 2 Te 3 . Introducing a new parameter F , degree of fluctuation of lattice, a relation between half-value width of rocking curve and the fluctuation of lattice parameter was obtained. It was shown that the solid solution becomes immiscible when the fluctuation of lattice parameter exceeds about 2.5%.
A Novel Topology for an Extendable Isolated DC-DC Multi-port Power Converter with a Multipurpose Hybrid Energy Storage System (2020)

There has been a growing interest in multi-port converters (MPCs) over the last several years. Applications such as solar and traction are prime candidates for employing MPCs. This paper presents a novel extendable DC-DC MPC which benefits from a uniquely designed hybrid energy storage system (HESS). Compared to the baseline converter, this proposed MPC reduces the number of active switches by 43 percent (from 21 to 12) while reducing the overall number of components by 26 percent. This is accomplished without sacrificing any functionality. The HESS provides the system with a faster response while reducing the main battery's size and enhancing its lifetime. Mathematical analysis and simulation results for this MPC are presented and a prototype of the HESS part is built, and its test results verify mathematical and simulation results.
A Hermetic Wireless Subretinal Neurostimulator for Vision Prostheses (2011)

A miniaturized, hermetically encased, wirelessly operated retinal prosthesis has been developed for preclinical studies in the Yucatan minipig, and includes several design improvements over our previously reported device. The prosthesis attaches conformally to the outside of the eye and electrically drives a microfabricated thin-film polyimide array of sputtered iridium oxide film electrodes. This array is implanted into the subretinal space using a customized ab externo surgical technique. The implanted device includes a hermetic titanium case containing a 15-channel stimulator chip and discrete circuit components. Feedthroughs in the case connect the stimulator chip to secondary power and data receiving coils on the eye and to the electrode array under the retina. Long-term in vitro pulse testing of the electrodes projected a lifetime consistent with typical devices in industry. The final assembly was tested in vitro to verify wireless operation of the system in physiological saline using a custom RF transmitter and primary coils. Stimulation pulse strength, duration, and frequency were programmed wirelessly from a Peripheral Component Interconnect eXtensions for Instrumentation (PXI) computer. Operation of the retinal implant has been verified in two pigs for up to five and a half months by detecting stimulus artifacts generated by the implanted device.
Alliages al-fe-x elabores par metallurgie des poudres : microstructure, comportement, endommagement (1990)

Des alliages d'aluminium elabores par metallurgie des poudres destintes a des applications a haute temperature ont ete etudies du point de vue de leur microstructure et de leur comportement mecanique. Trois alliages se presenent sous forme de barres filees a partir de poudres atomisees ont ete testes: al-fe#8, al-fe#8-v#1-si#2 et al-fe#8-mo#2-zr#1. Des examens par meb et met ont montre que la microstructure de ces alliages est composee de grains correspondant aux particules issues de l'atomisation, ces grains etant subdivises en sous-grains dont les joints sont ancres par les precipites intermetalliques. Ces precipites ont ete identifies. Le durcissement de ces alliages a haute temperature (500-550 k) est attribue a leur fine taille de sous-grains. Le creux de ductilite entre la temperature ambiante et ces temperatures est interprete a l'aide d'un modele couplant endommagement et comportement. Des essais de tenacite entre 77 k et 525 k ont egalement ete realises. Les examens des facies de rupture, notamment par la technique des repliques extractives montrent que les oxydes provenant de la surface des particules de poudre sont responsables de faibles valeurs de tenacite mesurees
ELECTROSPINNING TECHNOLOGY: A NOVEL APPROACH TO SENSOR APPLICATION (2002)

Abstract The synthesis, fabrication, fluorescence and fluorescence quenching behavior of fluorescent polymer, polyacrylic acid-poly (pyrene methanol) (PAA-PM) are reported. The Stern-Volmer plots of the electrospun membranes exhibited good linearity for Fe3+, Hg2+ and DNT and the Stern-Volmer constants Ksv are 4.4×104 (M−1), 3.5×104 (M−1) and 2.9×104 (M−1), respectively. These values are one order of magnitude more than those obtained previously from films made by electrostatic layer-by-layer adsorption of the same polymer.
Visualizing the entire DNA from a chromosome in a single frame (2015)

The contiguity and phase of sequence information are intrinsic to obtain complete understanding of the genome and its relationship to phenotype. We report the fabrication and application of a novel nanochannel design that folds megabase lengths of genomic DNA into a systematic back-and-forth meandering path. Such meandering nanochannels enabled us to visualize the complete 5.7 Mbp (1 mm) stained DNA length of a Schizosaccharomyces pombe chromosome in a single frame of a CCD. We were able to hold the DNA in situ while implementing partial denaturation to obtain a barcode pattern that we could match to a reference map using the Poland-Scheraga model for DNA melting. The facility to compose such long linear lengths of genomic DNA in one field of view enabled us to directly visualize a repeat motif, count the repeat unit number, and chart its location in the genome by reference to unique barcode motifs found at measurable distances from the repeat. Meandering nanochannel dimensions can easily be tailored to human chromosome scales, which would enable the whole genome to be visualized in seconds.
copia-like retrotransposons are ubiquitous among plants. (1992)

Transposable genetic elements are assumed to be a feature of all eukaryotic genomes. Their identification, however, has largely been haphazard, limited principally to organisms subjected to molecular or genetic scrutiny. We assessed the phylogenetic distribution of copia-like retrotransposons, a class of transposable element that proliferates by reverse transcription, using a polymerase chain reaction assay designed to detect copia-like element reverse transcriptase sequences. copia-like retrotransposons were identified in 64 plant species as well as the photosynthetic protist Volvox carteri. The plant species included representatives from 9 of 10 plant divisions, including bryophytes, lycopods, ferns, gymnosperms, and angiosperms. DNA sequence analysis of 29 cloned PCR products and of a maize retrotransposon cDNA confirmed the identity of these sequences as copia-like reverse transcriptase sequences, thereby demonstrating that this class of retrotransposons is a ubiquitous component of plant genomes.
Synthesis of the Blood Circulating C-terminal Fragment of Insulin-like Growth Factor (IGF)-binding Protein-4 in Its Native Conformation (2005)

Insulin-like growth factor-binding proteins play a critical role in a wide variety of important physiological processes. It has been demonstrated that both an N-terminal and a C-terminal fragment of insulin-like growth factor-binding protein-4 exist and accumulate in the circulatory system, these fragments accounting for virtually the whole amino acid sequence of the protein. The circulating C-terminal fragment establishes three disulfide bridges, and the binding pattern of these has recently been defined. Here we show that the monodimensional 1H NMR spectrum of the C-terminal fragment is typical of a protein with a relatively close packed tertiary structure. This fragment can be produced in its native conformation in Escherichia coli, without the requirement of further refolding procedures, when synthesis is coupled to its secretion from the cell. The recombinant protein crystallizes with the unit cell parameters of a hexagonal system. Furthermore, it binds strongly to heparin, acquiring a well defined oligomeric structure that interacts with insulin-like growth factors, and promotes bone formation in cultures of murine calvariae.
The Butte Fire: A Case Study in Using LIDAR Measures of Pre-Fire Vegetation to Estimate Structure Loss Rates (2020)

The Butte Fire occurred in the northern Sierra Nevada foothills of California in September, 2015, resulting in the loss of two lives and an estimated 1,565 structures in 70,000 acres (28,000 ha.) burned. This study evaluates the utility of vegetation measures derived from pre-fire LIDAR data in predicting structure loss for the Butte Fire. Additional explanatory variables such as elevation, topography, structure density, and structure access are also examined to determine their impact on structure loss rates. Loss estimates based on LIDAR-derived vegetation measures are compared to estimates derived from infrared aerial imagery to evaluate the relative effectiveness of using LIDAR for this purpose.&#13;\nLIDAR-derived vegetation density in the 50-foot (15 m.) zone around each structure was found to be the most significant variable associated with structure loss. Elevation was the second most statistically significant predictor of structure loss. On average, a 10% increase in vegetation density in the 50-foot (15 m.) zone around each structure led to an estimated 10.2% increase in structure loss. A 1000 foot (300 m.) rise in elevation was associated with a 15% increase in structure loss. Topographic variables such as slope, aspect, and topographic position did not appear to have an important effect on structure losses. Measures of structure density and structure access also were not statistically significant predictors of structure loss rates. &#13;\nVegetation cover derived from infrared aerial imagery proved nearly as accurate as LIDAR-derived vegetation density in estimating the probability of structure loss.
Future challenges and opportunities for heterogeneous process technology. Towards the thin films, Zero Intrinsic Variability devices, Zero Power era (2014)

Linear scaling CMOS has encountered many hurdles which request new process modules, driven mainly by the maximization of energy efficiency. Fabrication at the sub 10nm node level will request Intrinsic Variability approaching to zero. The rapid growth of mobile, multifunctional and autonomous systems is hardly demanding to reach Zero Power consumption. The solutions to integrate Thin Film based devices, architectures and systems in order to face these challenges are described.
ChemInform Abstract: A Non‐Chiral Swallow‐Tailed Liquid Crystal Exhibiting a Smectic C Phase that has an Antiferroelectric Structure. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Transplantation of a fetal liver cell-loaded hyaluronic acid sponge onto the mesentery recovers a Wilson's disease model rat (2010)

An auxiliary liver represents a promising alternative for liver transplantation. The use of a large amount of mature hepatocytes, however, despite their high function, is limited in a clinical setting. Here, we propose a novel transplantation system that dramatically improved a diseased animal by incorporating fetal liver cells (FLCs) as a cell source, the mesentery as a transplantation site and a hyaluronic acid (HA) sponge as a cell scaffold. We transplanted wild-type Long Evans Agouti rat FLCs embedded in HA sponges onto the mesentery of Long Evans Cinnamon (LEC) rats, an animal model for Wilson's disease. The FLC-loaded HA sponges successfully grafted and consequently prevented jaundice. Accordingly, the treated animals showed a significant reduction in blood copper concentration, which consequently led to significant decreases in serum total bilirubin and direct bilirubin, and to a significant increase in albumin productivity. Furthermore, haematoxylin and eosin staining of the host livers demonstrated that fibrosis at the periportal area was moderated in the treated animals. In conclusion, we transplanted FLC-loaded HA sponges onto the mesenteric blood vessels, leading to thick, liver-like tissue possessing blood vessels, and the liver tissue engineered thus exhibited a remarkable therapeutic effect on the copper metabolism deficiency of LEC rats.
Comparison of Estimation Techniques for the Crankshaft Dynamics of an Opposed Piston Engine (2019)

Abstract This study provides a comparison of a linear and unscented Kalman filter to estimate the dynamics of a two-stroke opposed piston engine. These engines maintain several advantages over conventional internal combustion engines including reduced heat transfer, higher power to weight ratio, and a larger expansion ratio. Additionally, a crank angle phasing is introduced between the two cranks to improve scavenging efficiency. However, the coupling of the two crankshafts through a large geartrain can cause high amounts of noise and vibration harshness (NVH) and mechanical efficiency losses. By removing the geartrain and controlling the decoupled crankshafts with motor-generators, the NVH can be minimized while maintaining the benefits of crank angle phasing. To control the input torque of the motors to the engine, accurate estimations of the crankshaft position and dynamics are necessary. While the unscented Kalman filter exhibits lower estimation error, the filter is sensitive to model uncertainty relating to cylinder pressure, demanding further investigation of the robustness of the nonlinear filter.
Immunoglobulins on the surface of differently charged polymer nanoparticles (2020)

The overall success of nanocarriers in biomedical applications depends on their interaction with different proteins in blood. Immunoglobulins as a major protein class of the blood proteome may considerably influence the identity of the nanocarriers in blood. However, there is a lack of knowledge about the specific details of the interaction mechanism between different immunoglobulins and nanocarriers. Therefore, the authors have investigated the interaction of different immunoglobulin classes-namely, immunoglobulin G, A, and M-with different polystyrene model nanoparticles. The authors report that immunoglobulin interaction with nanoparticles strongly depends on the immunoglobulin class and surface charge of the nanoparticles. Furthermore, upon adsorption on the nanoparticles' surfaces, aggregation processes and denaturation of immunoglobulins were observed. This highlights the importance of nanocarriers' design in order to prevent unfavorable denaturation and adsorption processes of immunoglobulins on nanoparticle surfaces.
Integrated optical waveguide polarizer on glass with a birefringent polymer overlay (1998)

An integrated optical waveguide polarizer on glass is described. It is based on a filtering zone propagating only TE mode whereas the TM mode leaks out into a birefringent polymer simply deposited on the glass. The polymer is poled by a corona process. The measured polarization extinction ratio between TE and TM modes is better than 39 dB and the excess loss due to the filtering zone is less than 4 dB. The total loss is in the order of 7 dB.
Supplementary Figure 3 from Blocked Autophagy Using Lysosomotropic Agents Sensitizes Resistant Prostate Tumor Cells to the Novel Akt Inhibitor AZD5363 (2023)

&lt;p&gt;PDF file - 74 KB, Targeting autophagy enhances PI-103 activity to induce apoptosis in PC-3 tumor prostate cells.&lt;/p&gt;
Triboluminescence and the dynamics of crystal fracture (1980)

Triboluminescence appears concurrently with the sudden force decreases in the fracture region of the force versus compression curves of tartaric-acid, sugar, ammonium-tartrate, lithium-sulfate-monohydrate, and citric-acid-monohydrate crystals. This relationship suggests that the motion of cracks and thereby the creation of new surfaces is responsible for the excitation of triboluminescence in these crystals. All of these crystals exhibit triboluminescence from the second positive group of molecular nitrogen. The intensity and time dependence of triboluminescence is measured as a function of the velocity of impact of a piston on single crystals. A quantitative expression for time and impact velocity dependence of the triboluminescence intensity. $I=(\frac{\ensuremath{\eta}\mathrm{bV}{u}^{3}{v}^{3}}{{\ensuremath{\alpha}}^{2}{h}^{3}}){e}^{\ensuremath{-}\ensuremath{\alpha}t}{(1\ensuremath{-}{e}^{\ensuremath{-}\ensuremath{\alpha}t})}^{2}\mathrm{exp}[\ensuremath{-}(\frac{\ensuremath{\beta}{u}^{2}{v}^{2}}{{\ensuremath{\alpha}}^{2}{h}^{2}}){(\ensuremath{-}{e}^{\ensuremath{-}\ensuremath{\alpha}t})}^{2}],$ is derived from the movement and the interaction of mobile cracks. This equation explains the observed dependence of the triboluminescence intensity on the impact velocity, the applied stress, the temperature, and the crystal dimensions. The values of $\ensuremath{\alpha}$ and $\ensuremath{\beta}$ are determined from triboluminescence measurements. $\ensuremath{\alpha}$ is related to the viscosity of the crystal and $\ensuremath{\beta}$ is related to the attrition coefficient of mobile cracks in the crystal. The triboluminescence activity decreases over three orders of magnitude from sugar to citric-acid crystals.