gebhart/patrepeval huggingface dataset:
On the Importance of the Pearson Correlation Coefficient in Noise Reduction (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> Noise reduction, which aims at estimating a clean speech from noisy observations, has attracted a considerable amount of research and engineering attention over the past few decades. In the single-channel scenario, an estimate of the clean speech can be obtained by passing the noisy signal picked up by the microphone through a linear filter/transformation. The core issue, then, is how to find an optimal filter/transformation such that, after the filtering process, the signal-to-noise ratio (SNR) is improved but the desired speech signal is not noticeably distorted. Most of the existing optimal filters (such as the Wiener filter and subspace transformation) are formulated from the mean-square error (MSE) criterion. However, with the MSE formulation, many desired properties of the optimal noise-reduction filters such as the SNR behavior cannot be seen. In this paper, we present a new criterion based on the Pearson correlation coefficient (PCC). We show that in the context of noise reduction the squared PCC (SPCC) has many appealing properties and can be used as an optimization cost function to derive many optimal and suboptimal noise-reduction filters. The clear advantage of using the SPCC over the MSE is that the noise-reduction performance (in terms of the SNR improvement and speech distortion) of the resulting optimal filters can be easily analyzed. This shows that, as far as noise reduction is concerned, the SPCC-based cost function serves as a more natural criterion to optimize as compared to the MSE. </para>
Genome-wide analysis and literature-based survey of lipoproteins in Pseudomonas aeruginosa (2010)

Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen able to cause acute or chronic infections. Like all other Pseudomonas species, P. aeruginosa has a large genome, >6 Mb, encoding more than 5000 proteins. Many proteins are localized in membranes, among them lipoproteins, which can be found tethered to the inner or the outer membrane. Lipoproteins are translocated from the cytoplasm and their N-terminal signal peptide is cleaved by the signal peptidase II, which recognizes a specific sequence called the lipobox just before the first cysteine of the mature lipoprotein. A majority of lipoproteins are transported to the outer membrane via the LolCDEAB system, while those having an avoidance signal remain in the inner membrane. In Escherichia coli, the presence of an aspartate residue after the cysteine is sufficient to cause the lipoprotein to remain in the inner membrane, while in P. aeruginosa the situation is more complex and involves amino acids at position +3 and +4 after the cysteine. Previous studies indicated that there are 185 lipoproteins in P. aeruginosa, with a minority in the inner membrane. A reanalysis led to a reduction of this number to 175, while new retention signals could be predicted, increasing the percentage of inner-membrane lipoproteins to 20 %. About one-third (62 out of 175) of the lipoprotein genes are present in the 17 Pseudomonas genomes sequenced, meaning that these genes are part of the core genome of the genus. Lipoproteins can be classified into families, including those outer-membrane proteins having a structural role or involved in efflux of antibiotics. Comparison of various microarray data indicates that exposure to epithelial cells or some antibiotics, or conversion to mucoidy, has a major influence on the expression of lipoprotein genes in P. aeruginosa.
Surface acoustic waves in strain-engineered K0.7Na0.3NbO3 thin films (2018)

Epitaxial K0.7Na0.3NbO3 thin films are grown via metal-organic chemical vapor deposition on (110)-oriented TbScO3. The films are strained due to the substrate–film lattice mismatch and therefore exhibit a strong and anisotropic modification of all its ferroelectric properties. The compressive in-plane strain leads to a reduction of the ferroelectric transition temperature from approximately 700 K for unstrained K0.7Na0.3NbO3 to 324 K and 330 K with maximum permittivities of 10 270 and 13 695 for the main crystallographic directions [001]TSO and [11¯0]TSO, respectively. Moreover, the quite thin films (approx. 30 nm thick) exhibit very large piezoelectric properties. For instance, surface acoustic waves with intensities of up to 4.7 dB are recorded for wave propagation along the [11¯0]TSO direction. The signal is smaller (up to 1.3 dB) along [001]TSO, whilst for the intermediate direction [11¯2]TSO, the signal seems to vanish (&amp;lt;0.1 dB). The results indicate that the choice of material, (K,Na)NbO3, in combination with strain-engineering via epitaxial growth onto lattice-mismatched substrates represents a promising way to optimize ferroelectric materials for piezoelectric thin-film applications.
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors (2022)

Diversity Oriented Clicking (DOC) is a discovery method geared toward the rapid synthesis of functional libraries. It combines the best attributes of both classical and modern click chemistries. DOC strategies center upon the chemical diversification of core "SuFExable" hubs-exemplified by 2-Substituted-Alkynyl-1-Sulfonyl Fluorides (SASFs)-enabling the modular assembly of compounds through multiple reaction pathways. We report here a range of stereoselective Michael-type addition pathways from SASF hubs including reactions with secondary amines, carboxylates, 1<i>H</i>-1,2,3-triazole, and halides. These high yielding conjugate addition pathways deliver unprecedented β-substituted alkenyl sulfonyl fluorides as single isomers with minimal purification, greatly enriching the repertoire of DOC and holding true to the fundamentals of modular click chemistry. Further, we demonstrate the potential for biological function - a key objective of click chemistry - of this family of SASF-derived molecules as covalent inhibitors of human neutrophil elastase.
Innovations in Commercial Finance for the Water and Sanitation Sector: The Potential of Investment Platforms for Mobilizing Financing for Development at Scale (2020)

Massive amounts of investment are needed to meet the United Nations Sustainable Development Goals for water supply and sanitation. However, several challenges have limited the ability to mobilize commercial finance for the sector, including a complex political economy, high transaction costs and an unclear regulatory environment. Investment platforms are an online tool for bringing together investors and investees more efficiently. While they began as a way to simplify the trading of publicly held stocks, a wave of innovative fintech investment platforms are increasing investment in numerous sectors. Translating this innovation to the water and sanitation sector could help address the challenges that have limited private investment in the sector. An effective investment platform for water and sanitation would need to provide transparency, traceability, auditability, analytics and standardization, and could be extended to support emerging fintech innovations, including blockchain and crowdfunding. Governments and donors can support the development of investment platforms for water and sanitation by encouraging pilot initiatives and creating a supportive regulatory environment.
Different Regions of the HPV-E7 and Ad-E1A Viral Oncoproteins Bind Competitively but through Distinct Mechanisms to the CH1 Transactivation Domain of p300 (2012)

p300 is a transcriptional coactivator that participates in many important processes in the cell, including proliferation, differentiation, and apoptosis. The viral oncoproteins, adenovirus (Ad) E1A and human papillomavirus (HPV) E7, have been implicated in binding to p300. The Ad-E1A-p300 interaction has been shown to result in the induction of cellular proliferation, epigenetic reprogramming, and cellular transformation and cancer. The HPV-E7-p300 interaction, on the other hand, is not well understood. p300 contains three zinc-binding domains, CH1-CH3, and studies have shown that Ad-E1A can bind to the p300 CH1 and CH3 domains whereas E7 can bind to the CH1 domain and to a lesser extent to the CH2 and CH3 domains. Here we address how high-risk HPV16-E7 and Ad5-E1A, which have different structures, can both bind the p300 CH1 domain. Using pull-down, gel filtration, and analytical ultracentrifugation studies, we show that the N-terminus and CR1 domains of Ad5-E1A and the CR1 and CR2 domains of HPV16-E7 bind to the p300 CH1 domain competitively and with midnanomolar and low micromolar dissociation constants, respectively. We also show that Ad5-E1A can form a ternary complex with the p300 CH1 domain and the retinoblastoma pRb transcriptional repressor, whereas HPV16-E7 cannot. These studies suggest that the HPV16-E7 and Ad5-E1A viral oncoproteins bind to the same p300 CH1 domain to disrupt p300 function by distinct mechanisms.
Performance analysis of M-ary signals for optimum combining with multiple interferers in a Rayleigh fading channel (2001)

In this paper, a performance of M-ary signals for optimum combining with multiple co-channel interferers is analyzed in a flat Rayleigh fading channel. The closed-form expressions of average symbol error rate of M-ary phase shift keying and M-ary differential phase shift keying are derived by using the moment generating function-based approach and the orthogonal approximation which is employed to evaluate the eigenvalues of the covariance matrix of the received interference-plus-noise. This analysis is a convenient way of assessing the performance of optimum combining and comparing it with that of maximal-ratio combining. In the cases of the single and multiple interferer(s), the accuracy of the approximation is assessed through computer simulations.
A New Transient Frequency Acceptability Margin Based on the Frequency Trajectory (2018)

When the electric power system is disturbed, the transient frequency deviation may be large and harmful to its stable operation, especially in some small power systems. However, there is a lack of transient frequency acceptability margin (TFAM) which could be directly used by dispatchers. In this paper, a new TFAM is proposed based on the transient frequency acceptability index (TFAI). First, based on the frequency trajectory and the philosophy of “different weights to the different frequency offset levels”, a new TFAI is proposed combined with frequency thresholds and time duration limits. The effectiveness of the TFAI is verified, and the critical acceptable disturbance is determined by using the TFAI. Then, a new TFAM is proposed based on the critical acceptability disturbance. The proposed TFAM can quantitatively describe the distance of the operation point from the critical frequency acceptability point, and distinguish the transient frequency acceptability of different disturbances. Finally, with different simulations, the effectiveness and applicability of the proposed TFAM are verified. The TFAM can be used for disturbances with single-parameter and multiple parameters.
ChemInform Abstract: 1,8‐Anthracenediethynylbis(catechol Boronate): A Bidentate Lewis Acid on a Novel Framework. (1989)

Abstract Coupling of 1,8‐dichloroanthracene (I) with the silylated ethynylmagnesium bromide (II) produces the compound (III) which is converted into 1,8‐diethynylanthracene (IV) by removal of the trimethylsilyl groups with potassium fluoride.
Effect of the configuration of the methyl group at C‐4 on the capacity of 4‐methyl‐9β, 19‐cyclosteroids to be substrates of a cyclopropane cleavage enzyme from maize (1979)

Abstract The cyclopropane ring of 4α,14α,(24ξ)‐24‐trimethyl‐9β19‐cyclo‐5α‐cholestane‐3β‐ol is opened by microsomes isolated from maize embryos to yield 4α,14α,(24ξ)‐24‐trimethyl‐5α‐cholest‐8‐en‐3β‐ol. In contrast, when 4β,14α,(24ξ)‐24‐trimethyl‐9β, 19‐cyclo‐5α‐cholestane‐3β‐ol or 4,4,14α(24ξ)‐24‐tetramethyl‐9β, 19‐cyclo‐5α‐cholestane‐3β‐ol are used as substrates, no reaction takes place. These results show that the number and also the stereochemistry of the C‐4‐methyls control the enzymic reaction. A new synthetic method for preparing 4β‐methyl from 4α‐methyl sterols is also described.
Reliability and Validity of Wisconsin Upper Respiratory Symptom Survey, Korean Version (2011)

The WURSS-K is a reliable, valid, and responsive disease-specific questionnaire for assessing symptoms and QOL in Korean patients with common cold.
Utilize absorption modulation of an injection-locked Fabry-Perot laser diode to demonstrate all-optical multi-wavelength conversion (2008)

In this paper, we demonstrate an all-optical multi-wavelength converter using absorption modulation of an injection-locked Fabry-Perot laser diode (FP-LD). The multi-wavelength converter was operated at 2.5 Gb/s; it can simultaneously provide 1 to 4 output channels and support both inverted and non-inverted conversion. We optimized the pump beam’s wavelength, the polarization states of: the pump, the probes, and the FP-LD so that all converted outputs show high extinction ratios and negligible crosstalk power penalties. The results guarantee to increase the number of output channels. The proposed scheme can be applied to multicasting function as well as 1xN wavelength conversion in an all-optical wavelength division multiplexed network.
Multivalent Charge Carriers (2020)

Abstract Rechargeable battery technologies based on metal anodes coupled to the use of multivalent charge carrier ions hold promise of breakthroughs in energy density leapfrogging current state‐of‐the‐art Li‐ion battery technology. Cost and sustainability benefits are both a priori expected from the highly abundant metals employed. Yet, the large know‐how from the Li‐ion battery research field is not directly transferable – both the use of metal anodes and the migration of multivalent ions, within both electrolyte and electrodes, are technological bottlenecks to overcome. The concepts exhibit very different degrees of maturity; for magnesium, proof of concept was achieved in the year 2000 using low potential cathodes and a complex corrosive electrolyte with a narrow electrochemical stability window. Further progress since then has been slow, but the development of non‐nucleophilic electrolytes has paved the way for sulfur and organic polymer cathodes. For calcium, reversible plating and stripping of Ca 2+ was achieved only recently and now the development targets suitable cathodes enabling full cell proof of concept. Finally, for aluminum batteries, the main track has been somewhat different concepts based on intercalated anions, often in special carbons, from corrosive and chloride‐based electrolytes, but currently other electrolytes as well as true Al metal anodes are in foci. Overall, many and diverse obstacles remains, but the understanding and progress is indeed catching up rapidly. Given the promises and urgent need for next‐generation batteries, a successful multivalent battery technology would be timely.
Enabling 6G Applications in the Sky: Aeronautical Federation Framework (2023)

While the current deployment of 5G is concentrated on high-quality service delivery on a two-dimensional terrestrial area covering our planet's surface, ongoing 5G standardization already addresses parts of the third dimension with 5G Non Terrestrial Networks (5G-NTN). 6G is expected to further leverage aeronautical communication towards a full exploration and comprehensive unification of all three dimensions. In this way, future communication systems will not only encompass all kinds of aeronautical platforms such as satellites, High- Altitude Platforms (HAPs), civil aircrafts, (self-)flying taxis, and UAVs but shall also enable the unification of terrestrial and non-terrestrial networks on a service platform level. This is further challenging, due to the rather closed aeronautical systems so far. We believe that emerging technology concepts such as Mobile Edge Computing (MEC) and Software-Defined Networking (SDN) can provide a basis for the full integration of aeronautical systems into their terrestrial counterpart. However, these technologies render the management and orchestration of aeronautical systems complex. As a step towards the integration of aeronautical communication and services into 6G, we propose a framework for the collection, monitoring, and distribution of resources in the sky among heterogeneous flying objects. This enables high-performance services for a new era of 6G aeronautical applications. Based on our proposed Aeronautical Federation Framework, we introduce emerging application use cases including aeronautical edge computing, aeronautical sensor networks, and aircraft cabin networks. In turn, we derive research challenges for 6G aeronautical networks.
A Portable Tactical Field Sensor Array for an Infrasound Direction-Finding and Positioning System (2017)

Infrasound refers to sound frequencies below the threshold of human hearing, around 20 Hz or less. There are a variety of natural sources of infrasonic emissions, including thunderstorms, avalanches, meteors, earthquakes, volcanos, windstorms, etc.; as well as man-made sources of emissions, such as aircraft, heavy machinery, artillery, missile testing, road traffic, etc. Infrasound is especially attractive from a sensing perspective due to its ability to propagate long distances while suffering little from atmospheric or environmental attenuation. In this work, we describe the development of a man-portable “tactical” infrasound field sensor array that is small, lightweight, and can be rapidly set-up and torn-down as needed. The system is able to provide direction-finding capabilities to infrasound impulse sources with a directional accuracy of +/- 3 degrees. Such information could be used for alternative positioning schemes, as will be described in detail, or perhaps for direction-finding (homing) to acoustic sources of interest. Possible users could be military or search-and-rescue teams operating in GPS-denied environments; field researchers studying volcanology or seismology; or other geo-acoustic scientists and engineers.
The IUPS Physiome Project. International Union of Physiological Sciences. (2002)

Modern medicine is currently benefiting from the development of new genomic and proteomic techniques, and also from the development of ever more sophisticated clinical imaging devices. This will mean that the clinical assessment of a patient's medical condition could, in the near future, include information from both diagnostic imaging and DNA profile or protein expression data. The Physiome Project of the International Union of Physiological Sciences (IUPS) is attempting to provide a comprehensive framework for modelling the human body using computational methods which can incorporate the biochemistry, biophysics and anatomy of cells, tissues and organs. A major goal of the project is to use computational modelling to analyse integrative biological function in terms of underlying structure and molecular mechanisms. To support that goal the project is establishing web-accessible physiological databases dealing with model-related data, including bibliographic information, at the cell, tissue, organ and organ system levels. This paper discusses the development of comprehensive integrative mathematical models of human physiology based on patient-specific quantitative descriptions of anatomical structures and models of biophysical processes which reach down to the genetic level.
The difference of clinical features between primary colorectal malignant T cell lymphoma and primary colorectal malignant B cell lymphoma (2009)

Objective To investigate the difference of clinical features between primary colorectal malignant T cell lymphoma and primary colorectal malignant B cell lymphoma.Methods Forty cases diagnosed as primary eolorectal malignant lymphoma (PCML) between Jan 1999 and May 2008 were studied retrospectively.Results The average age of 40 patients with PCML was (41.0±11.2) years old.Twenty-seven cases (67.5%) were diagnosed as B-cell lymphoma.Thirteen cases (32.5%) were diagnosed as T-cell lymphoma.Patients with T-cell lymphoma in PCML had more symptoms such as fever,night sweat and hematochezia,and was easier to perforate than those with B-cell lymphoma.Protrude type and single-focus and right-colon type were common in B-cell lymphoma under colonoscopy,but ulcerative type and multi-focus and fulbcolon were common in T-cell lymphoma.B-cell lymphoma had an earlier diagnosis,and more opportunities for surgery than T-cell lymphoma.Conclusions The misdiagnostic rate for PCML was high.Protrude type and single-focus and right-colon type were common in B-cell lymphoma under eolonoscopy,but ulcerative type and multi-focus and full-colon were common in T-cell lymphoma.B-cell lymphoma could be diagnosed earlier.

Key words: 
Lymphoma; Colorectal neoplasms; Endoscopy
Supplementary Table S3 from Chromatin-Remodeling Complex SWI/SNF Controls Multidrug Resistance by Transcriptionally Regulating the Drug Efflux Pump ABCB1 (2023)

&lt;p&gt;Hits from Doxorubicin Forwards Genetic Screen.&lt;/p&gt;
Design of an articulated mini-fixation device for proximal interphalangeal joint finger fractures (2007)

info:eu-repo/semantics/published
The Effect of Temperature on the Stability of African Swine Fever Virus BA71V Isolate in Environmental Water Samples (2023)

African swine fever virus (ASFV) is known to be very stable and can remain infectious over long periods of time especially at low temperatures and within different matrices, particularly those containing animal-derived organic material. However, there are some gaps in our knowledge pertaining to the survivability and infectivity of ASFV in groundwater. This study aims to determine the stability and infectivity of the cell culture-adapted ASFV strain BA71V by plaque assay after incubation of the virus within river water samples at three different environmentally relevant temperatures (4 °C, 15 °C, and 21 °C) over the course of 42 days. The results from this study indicate that ASFV can remain stable and infectious when maintained at 4 °C in river water for more than 42 days, but as incubation temperatures are increased, the stability is reduced, and the virus is no longer able to form plaques after 28 days and 14 days, respectively, when stored at 15 °C and 21 °C. Characterizing the survivability of ASFV in groundwater can allow us to develop more appropriate inactivation and disinfection methods to support disease control and mitigate ASFV outbreaks.
Sulfide Stress Cracking Resistance of Post Expanded Low Alloy Steel Tubulars (2006)

Abstract Sulfide Stress Cracking (SSC) performance before and after expansion of expandable tubulars for API L80 class was investigated with C-ring test and tensile test methods which follow NACE Standard TM0177-96[1]. The expansion ratio was 20%. Mechanical properties before and after expansion were also investigated. The expandable tubulars were quenched and tempered HF-ERW pipes and consisted of tempered martensite microstructure. In both of the C-ring tests and tensile tests, SSC did not occurred under 0.01MPa partial pressure of H2S at pH of 3.5, which is a rather severe sour environment, for the post-expanded pipes. These results suggest that expansion does not deteriorate SSC resistance under 0.01MPa partial pressure of H2S at pH of 3.5.