gebhart/patrepeval huggingface dataset:
Reconstructive Options for Osteonecrosis of the Femoral Head (2001)

The treatment of symptomatic osteonecrosis of the femoral head presents a challenge, particularly in young patients with significant femoral head deformity. Whereas retention of the femoral head is widely accepted as the goal of early treatment, attempts to reconstitute the femoral head are usually unsuccessful, and some form of replacement arthroplasty must be considered. When subchondral fracture and segmental collapse have occurred, especially if accompanied by degenerative changes in the acetabulum, hip reconstruction is usually recommended. Advanced stage avascular necrosis of the femoral head remains a particularly challenging disease to treat because it most commonly affects young, active patients in the third through fifth decades of life. Treatment of patients in this demographic is challenging in that a functional and durable hip operation is required. In the majority of patients requiring hip reconstruction, total hip replacement is the procedure of choice. Utilizing contemporary instrumentation and techniques, results in patients with osteonecrosis are becoming more predictable. Our efforts remain focused on improving the durability and long-term survivorship of total hip replacement. In this article we will review the information available on total hip arthroplasty and its various forms.
Second Harmonic Generation from Arrays of Nonlinear Metamaterial Nanocavities. (2015)

Abstract not provided.
Generalizable Patch-Based Neural Rendering (2022)

Neural rendering has received tremendous attention since the advent of Neural Radiance Fields (NeRF), and has pushed the state-of-the-art on novel-view synthesis considerably. The recent focus has been on models that overfit to a single scene, and the few attempts to learn models that can synthesize novel views of unseen scenes mostly consist of combining deep convolutional features with a NeRF-like model. We propose a different paradigm, where no deep features and no NeRF-like volume rendering are needed. Our method is capable of predicting the color of a target ray in a novel scene directly, just from a collection of patches sampled from the scene. We first leverage epipolar geometry to extract patches along the epipolar lines of each reference view. Each patch is linearly projected into a 1D feature vector and a sequence of transformers process the collection. For positional encoding, we parameterize rays as in a light field representation, with the crucial difference that the coordinates are canonicalized with respect to the target ray, which makes our method independent of the reference frame and improves generalization. We show that our approach outperforms the state-of-the-art on novel view synthesis of unseen scenes even when being trained with considerably less data than prior work.
Stress and Distortion Simulation of Additive Manufacturing Process by High Performance Computing (2018)

Numerical simulation is an efficient way to better understand the thermal and mechanical evolution during metal additive manufacturing (AM) and to design and optimize the process. However, with today’s computational tools, pass-bypass thermal-mechanical numerical simulation of the metal AM process is extremely time-consuming. In this study, a new finite element code recently developed in house at Oak Ridge National Lab was used for additive manufacturing simulation. Our new code effectively utilizes GPU based high-performance computers to allow for realistic simulation of the transient thermal and mechanical response of materials during additive manufacturing. A benchmark study on a cylinder model by powder bed selective laser melting was carried out and distortion profile was compared to the experimental measurements. The accuracy and efficiency of the code was also demonstrated by analyzing a wire and arc additive manufacturing (WAAM) model which consists of a base plate and four deposited layers.
Asymmetric synthesis of epoxides from aldehydes mediated by (+)-(2R,5R)-2,5-dimethylthiolane (1999)

Nonracemic epoxides were prepared by reaction of (+)-(2R,5R)-2,5-dimethylthiolane, benzyl bromide and a mineral base with an aldehyde. Various parameters (solvent, base, aldehyde, sulfide) have been investigated. These studies led to the optimisation of a practical and simple procedure. Acetonitrile or tert-butyl alcohol were used in the presence of water and potassium or sodium hydroxide at room temperature. These conditions gave 87–93% yields with aromatic or branched aliphatic aldehydes and enantiomeric excesses ranged from 66 to 96%. Kinetic studies and stereochemical analyses have been carried out and a transition state was suggested to rationalize the observed stereochemistry.
Towards early sepsis detection from measurements at the general ward through deep learning (2021)

Sepsis is one of the leading causes of death in the hospital. Several warning scores have been developed to categorize patients’ degrees of illness, with the purpose of recognizing sepsis onset at an early stage and consequently reducing time before starting treatment. The most accurate classification method, known as the SOFA score, is developed for use in the intensive care unit (ICU). Sepsis is not exclusively developing in the ICU and may occur in any hospitalized patient. Therefore, a reliable method for sepsis recognition using routinely gathered information from the general ward is of major importance. Recently, the use of computational methods has been proposed for early sepsis prediction. Multiple sepsis classifiers have been devised using machine learning methods. We validated a linear classification model and improved upon it using a deep neural network trained on data from the MIMIC-III database. The reference model approach yielded an Area Under Precision-Recall Curve (AUPRC) of 0.45 for a 3-h prediction time. Our newly constructed deep neural network outperformed the reference model, reaching an AUPRC of 0.49 for a 3-h prediction time. These results demonstrate to be robust for multiple prediction times, utilizing different datasets and multiple sepsis criteria. Our results are comparable to a high-resolution model, yet using only 8 simple and commonly performed measurements, instead of the complex set of dozens of measurements leveraged by other authors. Moreover, our method proves to adapt to different datasets and sepsis criteria, yielding a high accuracy. Therefore, sepsis onset prediction may also be viable in less monitored environments in the hospital, such as the general ward and the emergency room.
A physiological simulation model of the glucose-insulin system (2003)

We have developed a new physiologically based simulation model of the glucose insulin system which describes the main events occurring in a normal life day. The model is based on recent quantitative knowledge that has become available on glucose unit processes during a meal. The model is nonlinear and predicts the time course of glucose and insulin fluxes and pools of a normal subject having breakfast, lunch and dinner. The model provides a realistic framework for examining various facets of the glucoregulatory system and will be the basis for developing a Type I diabetes model.
Navigator-Guided Motion and B0 Correction of T2*-Weighted Magnetic Resonance Imaging Improves Multiple Sclerosis Cortical Lesion Detection (2021)

Navigator-guided motion and B0 correction substantially improves the overall image quality of T2*w magnetic resonance imaging at 7 T and increases its sensitivity for cortical lesions.
The Feasibility of Interference Alignment for Full-Duplex MIMO Cellular Networks (2015)

The feasibility condition of interference alignment (IA) for full-duplex (FD) multiple-input multiple-output (MIMO) cellular networks is considered. A necessary condition and a sufficient condition on the IA feasibility are established, characterizing the optimal sum degrees of freedom (DoF) for a broad class of network topologies. The necessary and sufficient condition is shown specially for a class of symmetric network topologies. The results demonstrate that FD operation at the base station with appropriate IA is able to improve the sum DoF than the conventional half-duplex operation.
Stereospecific Total Synthesis of the Indole Alkaloid Ervincidine. Establishment of the C-6 Hydroxyl Stereochemistry (2014)

The total synthesis of the indole alkaloid ervincidine (3) is reported. This research provides a general entry into C-6 hydroxy-substituted indole alkaloids with either an α or a β configuration. This study corrects the errors in Glasby's book (Glasby, J. S. Encyclopedia of the Alkaloids; Plenum Press: New York, 1975) and Lounasmaa et al.'s review (Lounasmaa, M.; Hanhinen, P.; Westersund, M. In The Alkaloids; Cordell, G. A., Ed.; Academic Press: San Diego, CA, 1999; Vol. 52, pp 103-195) as well as clarifies the work of Yunusov et al. (Malikov, V. M.; Sharipov, M. R.; Yunusov, S. Yu. Khim. Prir. Soedin. 1972, 8, 760-761. Rakhimov, D. A.; Sharipov, M. R.; Aripov, Kh. N.; Malikov, V. M.; Shakirov, T. T.; Yunusov, S. Yu. Khim. Prir. Soedin. 1970, 6, 724-725). It establishes the correct absolute configuration of the C-6 hydroxyl function in ervincidine. This serves as a structure proof and corrects the misassigned structure reported in the literature.
Identification of nonminimum phase MA systems using cepstral operations on slices of higher order spectra (1992)

Recursive and least-squares methods for reconstructing the impulse response of a nonminimum phase, linear time-invariant (NMP-LTI) MA system from its (k+1)st-order spectrum (k>1) are presented. The methods are nonparametric. They are based on computing the complex cepstrum of the impulse response sequences of the unknown system from the diagonal slice of the (k+1)st-order spectrum. The computational complexity of the system identification problem can be considerably reduced by using slices of higher-order spectra.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Coherent Tm-fiber Raman-soliton amplifier (2011)

The molecular fingerprint region from 2 – 10 °m is currently receiving a lot of interest due to its potential for enabling the identification of many important molecules in biological and medical applications. Particularly mid-IR comb laser systems are highly sought, since they could potentially revolutionize mid-IR and far IR spectroscopy. However, to date no robust comb technology operating in the 2 µm spectral region has been available. Tm fiber lasers have been known as versatile sub ps sources for the 2 µm spectral region for a long time, but their application to comb technology has been hampered by the long pulses generated by even the best Tm oscillators, i.e. to date the shortest pulses generated from Tm fiber oscillators were around 173 fs [1].
Characterizing the Escherichia coli O157:H7 Proteome Including Protein Associations with Higher Order Assemblies (2011)

Nearly all E. coli O157:H7 proteins encoded by prophage regions were expressed at low abundance levels or not detected. Comparative quantitative analyses of proteins from distinct cell lysate fractions allowed us to associate uncharacterized proteins with membrane attachment, potential participation in stable protein complexes, and susceptibility to aggregation as part of larger structural assemblies.
Efficient expanded-beam multimode fiber-optic coupler based on nonimaging optics (1988)

Expanded beam fiber-optic couplers offer great convenience for fiber cable connection, which is very desirable for local area network and other short-haul applications. But because most short-haul fibers are usually multimode, the large core causes significant aberration losses in conventional designs such as aspherics and GRIN lenses. Based on Liouville's theorem applied to nonimaging optics, we have developed a class of high efficiency expanded beam multimode fiber-optic coupler.
Cardiac Myocyte Apoptosis Is Associated With Increased DNA Damage and Decreased Survival in Murine Models of Obesity (2005)

Disruption of leptin signaling is associated with obesity, heart failure, and cardiac hypertrophy, but the role of leptin in cardiac myocyte apoptosis is unknown. We tested the hypothesis that apoptosis increases in leptin-deficient ob/ob and leptin-resistant db/db mice and is associated with aging and left ventricular hypertrophy, increased DNA damage, and decreased survival. We studied young (2- to 3-month-old) and old (12- to 14-month-old) ob/ob and db/db mice and wild-type (WT) controls (n=2 to 4 per group). As expected, ventricular wall thickness and heart weights were similar among young ob/ob, db/db, and WT mice, but higher in old ob/ob and db/db versus old WT. Young ob/ob and db/db showed markedly elevated apoptosis by TUNEL staining and caspase 3 levels compared with WT. Differences in apoptosis were further accentuated with age. Leptin treatment significantly reduced apoptosis in ob/ob mice both in intact hearts and isolated myocytes. Tissue triglycerides were increased in ob/ob hearts, returning to WT levels after leptin repletion. Furthermore, the DNA damage marker, 8oxoG (8-oxo-7,8-dihydroguanidine), was increased, whereas the DNA repair marker, MYH glycosylase, was decreased in old ob/ob and db/db compared with old WT mice. Both ob/ob and db/db mice had decreased survival compared with WT mice. We conclude that leptin-deficient and leptin-resistant mice demonstrate increased apoptosis, DNA damage, and mortality compared with WT mice, suggesting that normal leptin signaling is necessary to prevent excess age-associated DNA damage and premature mortality. These data offer novel insights into potential mechanisms of myocardial dysfunction and early mortality in obesity.
Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans (2011)

Selenoproteins, in particular thioredoxin reductase, have been implicated in countering oxidative damage occurring during aging but the molecular functions of these proteins have not been extensively investigated in different animal models. Here we demonstrate that TRXR-1 thioredoxin reductase, the sole selenoprotein in Caenorhabditis elegans, does not protect against acute oxidative stress but functions instead together with GSR-1 glutathione reductase to promote the removal of old cuticle during molting. We show that the oxidation state of disulfide groups in the cuticle is tightly regulated during the molting cycle, and that when trxr-1 and gsr-1 function is reduced, disulfide groups in the cuticle remain oxidized. A selenocysteine-to-cysteine TRXR-1 mutant fails to rescue molting defects. Furthermore, worms lacking SELB-1, the C. elegans homolog of Escherichia coli SelB or mammalian EFsec, a translation elongation factor known to be specific for selenocysteine in E. coli, fail to incorporate selenocysteine, and display the same phenotype as those lacking trxr-1. Thus, TRXR-1 function in the reduction of old cuticle is strictly selenocysteine dependent in the nematode. Exogenously supplied reduced glutathione reduces disulfide groups in the cuticle and induces apolysis, the separation of old and new cuticle, strongly suggesting that molting involves the regulated reduction of cuticle components driven by TRXR-1 and GSR-1. Using dauer larvae, we demonstrate that aged worms have a decreased capacity to molt, and decreased expression of GSR-1. Together, our results establish a function for the selenoprotein TRXR-1 and GSR-1 in the removal of old cuticle from the surface of epidermal cells.
A Verilog-A Model of the Shuttle of an Electron in a Two Quantum-Dot System (2019)

We describe a model of the bi-directional tunneling motion, also referred to as “shuttle”, of an electron between two quantum dots operating at cryogenic temperatures. The model, written in Verilog-A, is simulated in a Cadence Spectre environment with interfacing elements that constitute a quantum experiment test bench. This method of simulating a quantum structure paves the way for the analysis of sophisticated quantum experiments over a large number of cells and top level SoC verification.
Programming: Maximizing Benefit and Minimizing Morbidity Programming (2012)

Properly programming pacemakers and defibrillators siginificantly affects their function and the patient's health. Proper programming can add years to device longevity, prevent symptoms, lower the risk of atrial fibrillation, congestive heart failure and death. This chapter systematically reviews pacemaker, defibrillator, and resynchronization device programming. Key programmable parameters are reviewed, and patient-based approaches to optimize clinical outcomes summarized.
Active noise control for centrifugal and axial fans (2020)

Fans are widely used in industry for heat dissipation or airflow production. It is achieved by driving a motor of fan to rotate a number of blades. Most industrial fans can be categorized into one of two general types: centrifugal fans and axial fans. However, fan noise is loud when the motor speed is high. This article develops using active noise control (ANC) system to reduce noise from both centrifugal and axial fans. By integrating loudspeakers and microphones, we present multiple-channel feedback ANC structure with the filtered-X least mean square (FXLMS) algorithm to simultaneously reduce noise from the inlet and the outlet of the fans. Several realtime experiments verify that the proposed method and experimental setup not only reduces the narrowband noise but also achieves the global cancellation of the fan noise.
Scanning sequences after Gibbs sampling to find multiple occurrences of functional elements (2006)

Datasets from experiments determining the binding sites of transcription factors were used to evaluate the improvement to A-GLAM. Typically, the datasets included several sequences containing multiple instances of a regulatory motif. The improvements to A-GLAM permitted it to predict the multiple instances.
A Survey of Clinical Signs and Symptoms of Mouth Breathing in School Children (Part I). (1974)

Mouth breathing is an important etiological factor of chronic gingivitis and marginal periodontitis as well as dental plaque and calculus. The purpose of this study is to demonstrate (a) the frequency of clinical signs of mouth breathing in school children (b) correlation between 8 individual signs (c) relationship between prevelance of gingivitis (PMA Index) and clinical signs and symptoms of mouth breathing (d) relationship between oral hygiene status (OHI) and each clinical signs. The materials were examined, 1) lipseal insufficiency 2) lipdrying 3) over jet 4) open bite 5) mouth breathing line 6) tension ridge of palatal and lingual surface 7) hypertrophy of tonsils 8) lack of uvular reflex. As the result of this investigation, the followings were concluded. 1) Lip-seal insufficiency, mouth breathing line, hypertrophy of tonsils and lack of uvular reflex were found in more than 50% of children. 2) Lip-seal insufficiency, lip drying, over jet, mouth breathing line and tension ridge were related each other respectively. 3) Excepting hypertrophy of tonsils and lack of uvular reflex, all other signs were individually related to both of OHI and PMA.
Ion spray liquid chromatography/ion trap mass spectrometry determination of biomolecules (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIon spray liquid chromatography/ion trap mass spectrometry determination of biomoleculesScott A. McLuckey, Gary J. Van Berkel, Gary L. Glish, Eric C. Huang, and Jack D. HenionCite this: Anal. Chem. 1991, 63, 4, 375–383Publication Date (Print):February 15, 1991Publication History Published online1 May 2002Published inissue 15 February 1991https://pubs.acs.org/doi/10.1021/ac00004a015https://doi.org/10.1021/ac00004a015research-articleACS PublicationsRequest reuse permissionsArticle Views249Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Outage Probability and Throughput of SWIPT Relay Networks with Differential Modulation (2017)

In this paper, we investigate the application of differential modulation in simultaneous wireless information and power transfer (SWIPT) relay networks. Considering time switching (TS) and power splitting (PS) receiver architectures, we adopt a moments-based approach to derive novel expressions for the outage probability and throughput of SWIPT relay systems with the amplify-and-forward (AF) relaying protocol. We quantify the impact of several system parameters involving the energy conversion efficiency and the TS and PS ratio assumptions, imposed on the energy harvesting (EH) relay terminal. Our results reveal that the throughput performance of the TS protocol is superior to that of the PS protocol at lower receive signal-to-noise (SNR) values, which is in contrast to point-to-point SWIPT systems. A Monte Carlo simulation study is presented to corroborate the proposed analysis.
Design of broad-band matching network with lossy junctions using the real-frequency technique (1998)

A computer-aided design (CAD) procedure based on the real-frequency technique (RFT) is introduced for treating the matching of an arbitrary load to a complex generator. In this paper, the method has been applied to the design of interstage matching networks for microwave active circuits. The RFT provides several advantages over most of the usual techniques. It requires neither any transistor model because it directly includes measuring scattering- and noise-parameter data, nor a predetermined matching-circuit topology is necessary. A low-noise amplifier (LNA) design proceeding directly from experimental data is presented. Moreover, a new idea for treating the broadband matching problem leads to the use of an equalizer topology containing cascaded transmission lines with lossy junctions. Thus, gain-flatness and stability are satisfied by designing the input and the output matching circuits by the line-segment technique. An example is presented for the matching of a 0.1-5 GHz amplifier.
Bipolar Charging of Aerosol Nanoparticles by a Soft X-ray Photoionizer. (2002)

A new bipolar charger for nanometer aerosols using soft X-ray photoionization was developed. The concentrations and mobility distributions of the positive and negative ions generated by the X-ray charger were investigated, and then the charging probability of nanoparticles was evaluated experimentally and theoretically. All experimental data of the X-ray charger were compared with those of a 241Am α-ray bipolar charger. It was found that the X-ray bipolar charger could produce at least about 3.5 times as high concentration of gaseous ions as the α-ray charger and thus could have particles attain the equilibrium bipolar charging state in shorter residence time than the α-ray charger. The charging state of particles attained by the X-ray charger was explained by theoretical calculations as well as α-ray bipolar charging. It was concluded that the X-ray charger would be a useful instrument for charging high number concentration nanoparticles in the electrical aerosol measurements.
Endothelial SCUBE2 Interacts With VEGFR2 and Regulates VEGF-Induced Angiogenesis (2016)

Endothelial SCUBE2 may be a novel coreceptor for VEGFR2 and potentiate VEGF-induced signaling in adult angiogenesis.