gebhart/patrepeval huggingface dataset:
Optimization and In Vivo Evaluation of an Oral Dual Controlled-Release Tablet Dosage Form of Insulin and Duck Ovomucoid (2008)

The objectives of the present study were to (1) optimize the release rate of insulin from compressed microparticulates and (2) compare the in vivo hypoglycemic effect of optimized insulin microparticulates with compressed enzyme inhibitor (duck ovomucoid) and without inhibitor. A 3-factor, 15-run Box Behnken design was used to construct polynomial models correlating the dependent and independent variables. Independent processing variables were rate of addition of the alcoholic Eudragit L100 dispersion, volume of the antisolvent, and compression pressure. Responses were cumulative percent of insulin released from 1-6 hours. Insulin and ovomucoid release was simultaneously analyzed by high-performance liquid chromatography. They demonstrated variable release rates, which were optimized to the Higuchi's square root of time model to release the insulin and the inhibitor over 6 hours. The relationship between dissolution profiles and process parameters were demonstrated by contour and response surface plots. In vivo hypoglycemic effect was evaluated in rabbits in a 3-way crossover design. Cocompressed microparticulates of insulin and duck ovomucoid displayed a 3.2-fold greater hypoglycemic effect when compared with a similar preparation without ovomucoid. This study demonstrated the potential benefits of dosage forms with dual controlled-release mechanisms for both the protein and enzyme inhibitor.
Induction of Protective Anti-Tumor Immunity by Gene-Modified Dendritic Cells (1998)

The context in which an antigen is presented shapes the nature of the immune response to that antigen and can result in B cell activation, T cell activation, or immune tolerance. To elicit anti-tumor immune responses, various cell types have been employed as cellular adjuvants with tumor antigens, and recently several groups have shown that dendritic cells (DCs), cultured with tumor lysates, tumor antigens, or peptides eluted from tumor cells, induced significant anti-tumor immunity in vivo. In all of these approaches, the DCs were pulsed with an exogenous source of antigen. An alternative method is to engineer DCs to express tumor antigens. We genetically modified DCs to express beta-galactosidase (beta-gal) as a surrogate tumor antigen and then tested the anti-tumor activity of the beta-gal+ DCs in mice against a beta-gal+ murine melanoma cell line. A single vaccination with the gene-modified DCs protected mice against a lethal dose of beta-gal-B16 melanoma cells and induced beta-gal-specific cytotoxic T lymphocytes. These results demonstrate that expression of tumor antigens by DCs is a potent method of inducing tumor antigen-specific responses in vivo.
Regenerative Medium-Voltage AC Drive Based on a Multicell Arrangement With Reduced Energy Storage Requirements (2005)

Multicell power circuit topologies have proved to be an effective alternative to medium-voltage ac drives. The main advantage is the improved power quality at both the ac system and the motor sides. However, several drawbacks are present in these configurations, such as a lack of sustained regenerative operating mode, uncontrolled input reactive power, and a large second current harmonic that is injected by the load into the dc link of each cell, which leads to a bulky electrolytic capacitor. This paper proposes to replace the input diode-based front-end rectifier with an active front-end rectifier in all cells of the topology and a novel control strategy in order to overcome the aforementioned drawbacks. In fact, the active front-end rectifier allows the topology to regenerate and the control strategy handles the reactive input power and reduces the large second current harmonic from the dc-link capacitor, thus reducing its size. These features are achieved without any penalties in the quality of both the ac input current and the motor voltage waveforms. Experimental results confirm the theoretical considerations.
Quantitative determination of methylene blue in environmental samples by solid-phase extraction and ultra-performance liquid chromatography-tandem mass spectrometry: a green approach (2014)

Industrial effluents with dyes may have appreciably high chemical oxygen demand and suspended solids, posing adverse effects to both humans and aquatic life; therefore, quantitative monitoring of these effluents is essential.
An optically-pumped silicon evanescent microring resonator laser (2009)

We demonstrate an optically-pumped hybrid silicon evanescent microring laser fabricated by a self-aligned process. Low threshold carrier densities (<2.5×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">18</sup> cm- <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> ) are measured for both 15 and 25 μm diameter devices. Lasing up to 50 °C is achieved with 0.1 nm/°C wavelength red shift rate.
Acoustic Measurements of the Boiling Stability Tests on THORS Sodium Loop (1978)

Acoustic data of boiling stability tests on the THORS (hermal-Hydraulic Out-of-Reactor Safety) facility were obtained using three sodium-immersible high temperature microphones. The data was analyzed in both the time and frequency domains and provides the following information: (1) the acoustic signal due to sodium boiling was clearly observed; (2) the signal level and the repetition rate of boiling pulses are directly proportional to the applied heat flux; (3) a typical boiling pulse consists of a high frequency signal due mainly to the bubble collapses and a low frequency void oscillation; (4) the frequency spectra of the boiling and background pulses can be mostly assigned to various acoustic resonance frequencies of the THORS loop. The characterization of these data is pertinent to the design of sodium boiling detection systems.
Coordinated scheduling and power control for downlink cross-tier interference mitigation in heterogeneous cellular networks (2013)

In heterogeneous cellular networks, the deployment of low-powered picocells provides user offloading and capacity enhancement. The expansion of a picocell's coverage by adding a positive bias for cell association can maximize these effects. Under this circumstance, downlink cross-tier interference from a macro base station to pico mobile stations in the expanded picocell range deteriorates those pico mobile stations' performance significantly. In this paper, a coordinated scheduling and power control algorithm is proposed, whereby the macro base station reduces its transmission power for those victim pico mobile stations in the expanded picocell range only on a set of resource blocks to minimize performance degradation at the macro base station. First, the transmission power level is calculated based on the mobile stations' channel condition and QoS requirements. Then, a set of resource blocks is determined by solving a binary integer programming to minimize the sum of transmission power reduction subject to victim pico mobile stations' QoS constraints. To reduce computational complexity, we utilize a heuristic algorithm, i.e., max-min greedy method, to solve the problem. Through system level simulations, we show that average and 5%-ile throughputs of victim pico mobile stations are significantly improved.
Interplay of buried histidine protonation and protein stability in prion misfolding (2017)

Misofolding of mammalian prion proteins (PrP) is believed to be the cause of a group of rare and fatal neurodegenerative diseases. Despite intense scrutiny however, the mechanism of the misfolding reaction remains unclear. We perform nuclear Magnetic Resonance and thermodynamic stability measurements on the C-terminal domains (residues 90-231) of two PrP variants exhibiting different pH-induced susceptibilities to aggregation: the susceptible hamster prion (GHaPrP) and its less susceptible rabbit homolog (RaPrP). The pKa of histidines in these domains are determined from titration experiments, and proton-exchange rates are measured at pH 5 and pH 7. A single buried highly conserved histidine, H187/H186 in GHaPrP/RaPrP, exhibited a markedly down shifted pKa ~5 for both proteins. However, noticeably larger pH-induced shifts in exchange rates occur for GHaPrP versus RaPrP. Analysis of the data indicates that protonation of the buried histidine destabilizes both PrP variants, but produces a more drastic effect in the less stable GHaPrP. This interpretation is supported by urea denaturation experiments performed on both PrP variants at neutral and low pH, and correlates with the difference in disease susceptibility of the two species, as expected from the documented linkage between destabilization of the folded state and formation of misfolded and aggregated species.
Parallel-Optical Interconnects&lt;tex&gt;$≫$&lt;/tex&gt;100 Gb/s (2004)

A parallel-optical interconnect with 12 channels operating at 8.5 Gb/s giving an aggregate data rate of 102 Gb/s is demonstrated, to the authors' knowledge, for the first time. The paper describes and demonstrates 13 /spl times/ 16-mm cross-section 12-channel parallel-optic transmitter and receiver modules with each channel operating at a data rate of 8.5-10 Gb/s. This was achieved using bottom-emitting 990-nm vertical-cavity surface-emitting lasers and bottom-illuminated InGaAs-InP photodetectors flip-chip bonded directly to 12-channel transmitter and receiver integrated circuits, respectively. In addition, 102-Gb/s link results are demonstrated over 100 m of 50-/spl mu/m-core standard multimode ribbon fiber. A bit-error ratio of <10/sup -13/ was measured on a single channel after transmission through 100 m of multimode fiber at a data rate of 8.5 Gb/s with all 12 channels operating simultaneously.
A Convenient Method for the Synthesis of 4,4‐Diarylbut‐1‐enes via the Successive Allylation of Aromatic Aldehydes and the Friedel—Crafts Alkylation Reaction of Aromatic Nucleophiles with the Intermediary Benzyl Silyl Ethers Using HfCl4 or Cl2Si(OTf)2. (2002)

Abstract For Abstract see ChemInform Abstract in Full Text.
Data from Evaluation of Promoter Hypermethylation Detection in Body Fluids as a Screening/Diagnosis Tool for Head and Neck Squamous Cell Carcinoma (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; To evaluate aberrant promoter hypermethylation of candidate tumor suppressor genes as a means to detect epigenetic alterations specific to solid tumors, including head and neck squamous cell carcinoma (HNSCC).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Using promoter regions identified via a candidate gene and discovery approach, we evaluated the ability of an expanded panel of CpG-rich promoters known to be differentially hypermethylated in HNSCC in detection of promoter hypermethylation in serum and salivary rinses associated with HNSCC. We did preliminary evaluation via quantitative methylation-specific PCR (Q-MSP) using a panel of 21 genes in a limited cohort of patients with HNSCC and normal controls. Using sensitivity and specificity for individual markers as criteria, we selected panels of eight and six genes, respectively, for use in salivary rinse and serum detection and tested these in an expanded cohort including up to 211 patients with HNSCC and 527 normal controls.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Marker panels in salivary rinses showed improved detection when compared with single markers, including a panel with 35% sensitivity and 90% specificity and a panel with 85% sensitivity and 30% specificity. A similar pattern was noted in serum panels, including a panel with 84.5% specificity with 50.0% sensitivity and a panel with sensitivity of 81.0% with specificity of 43.5%. We also noted that serum and salivary rinse compartments showed a differential pattern of methylation in normal subjects that influenced the utility of individual markers.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Q-MSP detection of HNSCC in serum and salivary rinses using multiple targets offers improved performance when compared with single markers. Compartment-specific methylation in normal subjects affects the utility of Q-MSP detection strategies.&lt;/p&gt;&lt;/div&gt;
Supplementary Figure 1 from Fibroblast Growth Factor Receptor 4 Regulates Tumor Invasion by Coupling Fibroblast Growth Factor Signaling to Extracellular Matrix Degradation (2023)

Supplementary Figure 1 from Fibroblast Growth Factor Receptor 4 Regulates Tumor Invasion by Coupling Fibroblast Growth Factor Signaling to Extracellular Matrix Degradation
PREVAIL: Predicting Recovery through Estimation and Visualization of Active and Incident Lesions (2016)

This study demonstrates that by using only information from a single visit at incidence, we can predict how a new lesion will recover using relatively simple statistical techniques. The potential to visualize the likely course of recovery has implications for clinical decision-making, as well as trial enrichment.
5G radio access (2014)

Mobile communication has evolved significantly from early voice systems to today's highly sophisticated integrated communication platforms that provide numerous services, and support countless applications used by billions of people around the world.
CD44s Induces miR-629-3p Expression in Association with Cisplatin Resistance in Head and Neck Cancer Cells (2020)

Cisplatin (cis-diamminedichloroplatinum II [CDDP] ) is a well-known chemotherapeutic drug that has been used for the treatment of various types of human cancers, including head and neck cancer. Cisplatin exerts anticancer effects by causing DNA damage, replication defects, transcriptional inhibition, cell cycle arrest, and the induction of apoptosis. However, drug resistance is one of the most serious problems with cancer chemotherapy, and it causes expected therapeutic effects to not always be achieved. Here, we analyzed global microRNA (miRNA) expression in CD44 standard form (CD44s)-expressing SAS cells, and we identified miR-629-3p as being responsible for acquiring anticancer drug resistance in head and neck cancer. The introduction of miR-629-3p expression inhibited apoptotic cell death under cisplatin treatment conditions, and it promoted cell migration. Among the computationally predicted target genes of miR-629-3p, we found that a number of gene expressions were suppressed by the transfection with miR-629-3p. Using a xenografting model, we showed that miR-629-3p conferred cisplatin resistance to SAS cells. Clinically, increased miR-629-3p expression tended to be associated with decreased survival in head and neck cancer patients. In conclusion, our data suggest that the increased expression of miR-629-3p provides a mechanism of cisplatin resistance in head and neck cancer and may serve as a therapeutic target to reverse chemotherapy resistance.
Las vacunas ante la diversidad antigénica de las bacterias (2007)

Bacterial pathogens have evolved a whole range of anti-immune strategies to overcome both the innate and acquired immunity of their hosts. These strategies play a crucial role in the capacity of pathogens to trigger disease and also explain why it is so difficult to develop vaccines and to control these microorganisms. One of the main problems is that bacteria are highly antigenically diverse. The vaccination strategies for coping with this variability, which we are starting to understand more fully as a result of sequencing bacterial genomes, consist of using either several variants of one or more proteins capable of inducing protective antibodies, or else proteins (or protein fragments) or epitopes that have been relatively well preserved notably because they are involved in the pathogen's metabolism. The most sophisticated approach calls upon 'pan genomic' inverse vaccinology which compares the protein profiles of a large number of isolates from various strains of a single species in order to reveal the surface-expressed proteins present in all the isolates. Of these proteins, the ones which are expressed when the host is infected are then evaluated in order to determine their capacity to induce a protective immune response. So far this approach has been successful in controlling bacteria in humans and the way is now open for its application in veterinary medicine, thanks to progress with the genomic sequencing of pathogens of veterinary importance.
BER Performance of W-CDMA Reciever Using Adaptive Array Antenna Technique in Indoor LOS/NLOS Environments (2007)

The wide band code division multiple access (W-CDMA) receiver combined with adaptive array antenna (AAA) technique is developed and used to measure the bit error rate (BER) performances in indoor line of sight (LOS) and non line of sight (NLOS) environments. Since the BER changes with the orientation of the receiving antenna in indoor environment, the mean BER is proposed by averaging all BERs at each orientation of receiving antenna along the azimuth direction. Compared with the single antenna when BER is equal to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> , the experimental results have demonstrated that signal-to-interference ratio (SIR) can be improved by 10 dB in indoor LOS environment and 8 dB in indoor NLOS environment, respectively.
Intrathecal interferon in subacute sclerosing panencephalitis (1986)

Five patients with clinically advanced subacute sclerosing panencephalitis (SSPE) were given human leukocyte interferon (IFN) by the lumbar route, 1 million IU every other day for a total of 30 days. Intrathecal IFN produced a meningeal inflammatory reaction in all patients and was associated with transient hemiparesis in 1. It persisted in the cerebrospinal fluid at measurable levels for 48 hours after a single injection. Although improvement was temporally related to intrathecal IFN in 1 patient, it is not clear whether this was induced by IFN or a spontaneous remission. A randomized controlled trial would be necessary to evaluate IFN critically as a therapy for SSPE.
A gold(i)-catalyzed route to α-sulfenylated carbonyl compounds from propargylic alcohols and aryl thiols (2012)

A one-step atom efficient gold(I)-catalyzed route to α-sulfenylated ketones and aldehydes from propargylic alcohols and aryl thiols is described.
Repeatable, accurate, and high speed multi-level programming of memristor 1T1R arrays for power efficient analog computing applications (2016)

Beyond use as high density non-volatile memories, memristors have potential as synaptic components of neuromorphic systems. We investigated the suitability of tantalum oxide (TaOx) transistor-memristor (1T1R) arrays for such applications, particularly the ability to accurately, repeatedly, and rapidly reach arbitrary conductance states. Programming is performed by applying an adaptive pulsed algorithm that utilizes the transistor gate voltage to control the SET switching operation and increase programming speed of the 1T1R cells. We show the capability of programming 64 conductance levels with <0.5% average accuracy using 100 ns pulses and studied the trade-offs between programming speed and programming error. The algorithm is also utilized to program 16 conductance levels on a population of cells in the 1T1R array showing robustness to cell-to-cell variability. In general, the proposed algorithm results in approximately 10× improvement in programming speed over standard algorithms that do not use the transistor gate to control memristor switching. In addition, after only two programming pulses (an initialization pulse followed by a programming pulse), the resulting conductance values are within 12% of the target values in all cases. Finally, endurance of more than 10(6) cycles is shown through open-loop (single pulses) programming across multiple conductance levels using the optimized gate voltage of the transistor. These results are relevant for applications that require high speed, accurate, and repeatable programming of the cells such as in neural networks and analog data processing.
Towards on-chip spectroscopy based on a single microresonator (2018)

Frequency comb generation in the mid-infrared (mid-IR)region is attractive recently. Here, we propose the Ge-on-Si microresonator for power-efficient frequency comb generation in the mid-IR. An octave-spanning comb can be obtained with power reduced to 190 mW. The robustness of the frequency comb generation with localized spectral loss is also analyzed. Based on the analysis, we propose a novel architecture of on-chip spectroscopy systems in the mid-IR.
Role of interleukins in the regulation of basophil development and secretion (2009)

Basophil regulation by cytokines in health and disease may be a more complex process than has been considered previously. Some of the affected cytokine cascades, receptors, and signal transduction molecules may serve as targets of therapy in 'basophil activation disorders' in the future.
A Discrete Element 3′ of Human Immunodeficiency Virus 1 (HIV-1) and HIV-2 mRNA Initiation Sites Mediates Transcriptional Activation by an HIV trans Activator (1988)

An important point of regulation in the reproductive growth and latency of the human and simian immunodeficiency viruses (HIV and SIV, respectively) is provided by virally encoded trans-activators (tat), proteins capable of dramatically increasing viral gene expression. The mechanism of this autostimulatory pathway has remained unclear, however, with substantial effects having been reported at the level of either mRNA accumulation, translational efficiency, or both. Our previous findings indicated that trans-activation results primarily from induction of RNA levels but could not distinguish between the roles of transcriptional rate, RNA stabilization, and RNA transport in this event. In addition, the boundaries of tat-responding elements, which would be valuable in elucidating the mode of tat action, are not precisely known. In this study, HIV-1 and HIV-2 long terminal repeat-directed expression was characterized by using an in vitro nuclear transcription assay to clarify this mechanism, and a detailed mutational analysis was undertaken to localize precisely the sequences participating in this process. Two key findings were revealed: an increased transcription rate was the primary event in tat-mediated activation of HIV-1 and HIV-2, and trans-activation was impaired by mutations in two regions, the TATA box and sequences between +19 to +42, a region lacking enhancer activity. These results implicate a discrete 3' regulatory element in the transcriptional activation of the HIVs.
Accelerated MR screenings with direct k-space classification (2023)

Despite its rich clinical information content, MR has seen limited adoption in population-level screenings, due to concerns about specificity combined with high scan duration and cost. In order to begin to address such issues, and to accelerate the entire pipeline from data acquisition to diagnosis, we introduce ARMS, an algorithm that learns k-space undersampling patterns to maximize the accuracy of pathology detection. ARMS detects pathologies directly from undersampled k-space data, bypassing explicit image reconstruction. We use ARMS to detect clinically significant prostate cancer and knee abnormalities in 2D MR scans, achieving an acceleration of 12.5x without compromising accuracy.