gebhart/patrepeval huggingface dataset:
Abstract 3: OncomiR-155 targets oncogenes HDAC4 and BCL6 in a murine B cell leukemia model: A paradigm shift in the oncogenic mechanisms of microRNAs (2010)

Abstract miR-155 belongs to a family of non-coding RNA, namely microRNAs (miRNAs) and is over-expressed in several lymphoid malignancies including chronic lymphocytic leukemia and diffuse large B-cell lymphomas. Transgenic over-expression of miR-155 in mouse B cells has been shown to induce pre-B cell proliferation followed by high-grade B-cell lymphoma. miR-155 exerts its oncogenic activity by targeting directly or indirectly tumor suppressor genes-SHIP-1 and C/EBPβ in B cells. To further characterize the mechanisms by which miR-155 contributes to leukemogenesis we did mRNA profiling of the B cells from the transgenic (TG) miR-155 mice spleens. Interestingly, we found that an oncogene Bcl-6 (B cell leukemia 6) was down regulated in the miR-155 TG B cells. Bcl-6 is a transcriptional repressor and a key regulator of germinal center B-cell development where antigen activated B cells differentiate to memory B cells or antibody producing plasma cells. Bcl6 is also involved in repression of cell cycle arrest and apoptosis associated genes by recruiting corepressors like histone deacetylases (HDACs). Further analysis of miR155 targets indicated another oncogene hdac4 to be a potential target. Luciferase reporter assay validated hdac4 as a direct target of miR155 which was further confirmed by 50% reduction in hdac4 mRNA and protein levels in TG mice by RT-PCR and immunoblotting respectively. To further investigate the effect of downegulation of hdac4 and Bcl6, we hypothesized that Bcl6 is functionally inactivated due to increased acetylation in TG mice and is targeted for ubiquitin mediated proteasome degradation due to downregulation of hdac4. Increased levels of acetylated Bcl6 in immunoprecipitated Bcl6 from total splenocytes of TG mice compared to WT control mice confirmed our hypothesis. This partly explains the post-translational regulation of Bcl6 indirectly by miR-155 through HDAC4. We further confirmed these findings in vitro in cultured cells lines with high and low expression of miR-155 and observed similar results of down regulation of HDAC4 and BCL6. In addition, we also observed significantly decreased proliferation of cells with high expression of miR-155 compared to cell lines with low expression of mir-155. mRNA analysis also showed significantly upregulation of genes involved in cell cycle arrest such as Cyclin D2/ccnd2, Cdkn1a and Inhibitor of differentiation 2/Id2) in TG mice compared to WT. These findings enlighten the complex interplay between tumor suppressor and oncogene pathways affected by a single gene, that when over-expressed results in leukemia. This indicates a shift in the paradigm of typical oncogenic miRNAs mechanisms, whereby they can act, not only by targeting tumor suppressors but also oncogenes. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3.
Network based Distributed Mobility Approach (2011)

This document presents an IEEE 802.21 based mechanism to enabled network based distributed mobility management.
Catalytic oxidation of carbon monoxide over of gold-supported iron oxide catalyst (2016)

In this work, a series of gold nanoparticles deposited on α-FeOOH nanorods were studied in relation to their performance in the low-temperature oxidation of CO. The catalysts were characterised by different techniques such as, Fourier transform infrared (FTIR), X-ray diffraction (XRD), N2 adsorption/desorption, hydrogen temperature programmed reduction (H2-TPR) and transmission electron microscope (TEM) images. The XRD proved the formation of α-FeOOH crystalline structure and also showed small diffraction peaks for Au-agglomerated particles on the surface. While TEM images revealed the formation of α-FeOOH with nanorod structure with different dimensions, TEM also showed some agglomerations of Au particles on the support surface. The H2-TPR experiments the enhancement of Au/α-FeOOH reducibility. The performance of Au/α-FeOOH in the CO oxidation was greatly affected by Au content and α-FeOOH preparation method.
A Novel Class of Cyclic .beta.-Dicarbonyl Leaving Groups and Their Use in the Design of Benzisothiazolone Human Leukocyte Elastase Inhibitors (1995)

Human leukocyte elastase (HLE) has been proposed to be a primary mediator of pulmonary emphysema, and inhibitors of this enzyme should be effective in the treatment of emphysema and other pulmonary diseases. We have discovered a novel class of alicyclic and heterocyclic leaving groups which share one common structural feature, a cyclic beta-dicarbonyl. This design concept for leaving groups has not been previously reported. A structure-activity relationship has been developed and the concept extended to several types of alicyclic and heterocyclic beta-dicarbonyl systems. This work led to the identification of a potent (K*i of 0.066 nM) and tissue stable (in vitro: blood t1/2 = 160 min, liver t1/2 > 240 min) benzisothiazolone HLE inhibitor, WIN 65936 (13b).
Supplementary Table 1 from Prostaglandin E<sub>2</sub> Impairs CD4<sup>+</sup> T Cell Activation by Inhibition of lck: Implications in Hodgkin's Lymphoma (2023)

Supplementary Table 1 from Prostaglandin E&lt;sub&gt;2&lt;/sub&gt; Impairs CD4&lt;sup&gt;+&lt;/sup&gt; T Cell Activation by Inhibition of lck: Implications in Hodgkin's Lymphoma
Active mitigation of induced phase distortion in a GSM SoC (2008)

A novel technique for the mitigation of self-interference in a GSM transmitter is presented. It was designed to mitigate the impact of interference caused by the transmitterpsilas high frequency signals to the on-chip circuitry responsible for generating the PLLpsilas crystal-based reference clock. Excessive jitter experienced in this reference clock causes intolerable modulation distortion, as it is effectively amplified by the PLL that produces the transmitterpsilas modulated carrier. The presented technique, leveraging on specific features of the all-digital PLL (ADPLL), was demonstrated in a GSM system-on-chip (SoC) based on the digital RF processor (DRPtrade) technology in 90 nm CMOS.
Purging of malignant cell contamination prior to spermatogonia stem cell autotransplantation to preserve fertility: progress & prospects (2019)

The success in treating childhood cancer has dramatically increased over the past few decades. This leads to increasing demand for a method of fertility preservation for patients with pediatric cancer, as many cancer therapies can be gonadotoxic. Storing the SSCs prior to chemo- or radiation therapies and transplanting them back has been tested as a method of restoring fertility in rodents and nonhuman primate models. This has promise for restoring fertility in childhood cancer survivors. One of the major concerns is the possibility of malignant cell presence in testicular tissue biopsies that could re-introduce cancer to the patient after SSCs autotransplantation. Non-solid cancers - especially hematologic malignancies - have the risk of being transplanted back into patients after SSCs cryopreservation even if they were only present in small number in the stored testicular tissue biopsy.
Discussion of fracturing in chalk completions (1985)

Chronic inflammatory rhinitis is commonly found in dogs with chronic nasal disease and is characterized by lymphoplasmacytic infiltrates in the nasal mucosa in the absence of an obvious etiologic process. The pathogenesis of lymphoplasmacytic rhinitis remains unknown. Animals respond poorly to antibiotics, oral glucocorticoids, and antihistamines, making primary infectious, immune-mediated, or allergic etiologies unlikely. Aberrant immune response to inhaled organisms or allergens may induce inflammation in some animals. Common clinical signs include nasal discharge, sneezing, coughing, epistaxis, and stertor. Diagnosis is made by performing a thorough history, physical examination, radiography or advanced imaging (via computed tomography or magnetic resonance imaging), rhinoscopy, and nasal mucosal biopsy to rule out primary etiologies of nasal discharge. Treatment strategies have included various antibiotics, antihistamines, oral and inhalant steroids, nonsteroidal antiinflammatories, and antifungal medications. Some dogs may respond partially to doxycycline or azithromycin, although it is unclear whether response is related to antimicrobial or antiinflammatory properties of these drugs. Hydration of the nasal cavity through nasal drops or aerosols may limit nasal discharge, and some animals may improve with inhalant (but rarely oral) glucocorticoids.
An Ontology for the Management of Heteregenous Alerts of Information System (2007)

International audience
Analysis and Optimization of Nonequilibrium Capillary Electrophoresis of α-Fetoprotein Isoforms (2007)

The L3 isoform of alpha-fetoprotein (AFP) is a specific marker for hepatocellular carcinoma. The separation and quantitation of L3 isoform from the L1 isoform is facilitated by Lens culinaris agglutin (LCA) affinity of the L3 isoform. The affinity-based separation is characterized by nonequilibrium conditions since electrophoresis perturbs the species concentrations away from equilibrium. The design of such separations requires careful consideration of the interplay between the reaction, diffusion, and separation time scales. We performed experiments to investigate the effect of separation parameters such as LCA concentration and CE voltage on the L1-L3 separation dynamics. We also describe a comprehensive mathematical model to predict electropherograms for affinity-based separations. The model includes the effects of molecular diffusion, electromigration, nonequilibrium reaction, and detection process. Together, the results demonstrate a process by which to optimize the affinity-based separations of AFP isoforms. We also obtained the kinetic rate constants for LCA affinity (kon=1.6x10(3) mol(-1) s(-1) L, koff=1x10(-3) s(-1)) by comparing the model predictions with experimental data. This study provides insight into the physics of affinity-based separations and can be extended to describe and optimize other nonequilibrium CE systems.
Application of Amplitude, Frequency, and Other Attributes to Stratigraphic and Hydrocarbon Determination: Section 2. Application of Seismic Reflection Configuration to Stratigraphic Interpretation (1977)

Improvements in seismic data acquisition and processing techniques make it possible to observe geologically significant information in seismic records which has not been evident in the past. New types of measurements help in locating and analyzing geologic features, including some hydrocarbon accumulations. Analysis of a seismic trace as a component of an analytic signal permits the transformation to polar coordinates and the measurement of quantities called reflection strength and instantaneous phase. These, plus several other quantities derived from them, are called attribute measurements and can be coded by color on seismic sections. Such color displays permit an interpreter to associate measurements and changes in measurements with structural and other fe tures in the seismic data. They thus facilitate identification of interrelations among measurements. A series of examples shows how such analysis and display helps in locating and understanding faults, unconformities, pinchouts, prograding deposition, seismic sequence boundaries, hydrocarbon accumulations, and stratigraphic and other variations which might be misinterpreted as hydrocarbon accumulations.
<title>Advances in passive millimeter wave imaging</title> (1994)

The status of passive millimeter wave radiometry as a thermal imaging technique will be discussed. Methods will be identified for overcoming the usual difficulties of poor spatial resolution and slow response time. High quality images will be presented to demonstrate the potential of this technology.
Elevation of serum lactate dehydrogenase in AL amyloidosis reflects tissue damage and is an adverse prognostic marker in patients not eligible for stem cell transplantation (2017)

The significance of serum lactate dehydrogenase (LDH) in light chain (AL) amyloidosis has not been previously explored. We studied 1019 newly diagnosed patients and correlated the elevation of LDH above the upper limit of normal (ULN) with disease characteristics and outcome. Four hundred and nine patients had an LDH above ULN, representing 40% of the study population. Patients with an elevated LDH were older, were less likely to be male and had more extensive organ involvement compared to patients with a normal LDH. Patients with high LDH had greater cardiac and renal dysfunction. Elevated LDH was an independent prognostic marker for overall survival and for death within 6 months of diagnosis, but this was restricted to patients not eligible for stem cell transplant. Serum LDH may act as a marker for organ damage and should be explored as a potential marker for tissue healing and organ recovery.
N-glycolyl chondroitin synthesis using metabolically engineered E. coli (2020)

N-glycolyl chondroitin (Gc-CN) is a metabolite of N-glycolylneuraminic acid (Neu5Gc), a sialic acid that is commonly found in mammals, but not humans. Humans can incorporate exogenous Neu5Gc into their tissues from eating red meat. Neu5Gc cannot be biosynthesized by humans due to an evolutionary mutation and has been implicated in causing inflammation causing human diseases, such as cancer. The study Neu5Gc is important in evolutionary biology and the development of potential cancer biomarkers. Unfortunately, there are several limitations to detecting Neu5Gc. The elimination of Neu5Gc involves a degradative pathway leading to the incorporation of N-glycolyl groups into glycosaminoglycans (GAGs), such as Gc-CN. Gc-CN has been found in humans and in animals including mice, lamb and chimpanzees. Here, we present the biosynthesis of Gc-CN in bacteria by feeding chemically synthesized N-glycolylglucosamine to Escherichia coli. A metabolically engineered strain of E. coli K4, fed with glucose supplemented with GlcNGc, converted it to N-glycolylgalactosamine (GalNGc) that could then be utilized as a substrate in the chondroitin biosynthetic pathway. The final product, Gc-CN was converted to disaccharides using chondroitin lyase ABC and analyzed by liquid chromatography-tandem mass spectrometry with multiple reaction monitoring detection. This analysis showed the incorporation of GalNGc into the backbone of the chondroitin oligosaccharide.
A Forward Chemical Screen Using Zebrafish Embryos with Novel 2‐Substituted 2H‐Chromene Derivatives (2009)

We synthesized 2-substituted 2H-chromene derivatives from salicylaldehyde using potassium vinylic borates in the presence of secondary amines. Our goal was to generate novel compounds that might modulate transforming growth factor-beta signaling, based on limited rational design. Potassium vinyl trifluoroborates react with salicylaldehydes at 80 degrees C in the presence of a secondary amine and produce 2-substituted 2H-chromene derivatives with a 70-90% yield. A small library of these compounds, predicted to potentially interact with transforming growth factor-beta receptors, was screened for bioactivity in living zebrafish embryos. We found that the related compounds differentially affect development, and demonstrate one compound that produces severe body axis alterations in early embryogenesis and at lower doses affects specifically cardiovascular development. This compound modulates specifically a Smad-independent transforming growth factor-beta-regulated mitogen-activated protein kinase pathway, namely p-SAPK/JNK. These compounds, as suggested by our biological assays, may prove useful to manipulate developmental programs and develop therapeutic tools.
An Allocation Dilemma with Closed-Loop Recycling (1997)

&lt;div class="htmlview paragraph"&gt;How does a company determine if a new product or process has less or more impact on the environment? Or do we just assume that because it has recycled content it has less impact on the environment? A life cycle assessment can be used to better understand the impacts and the trade-offs. The authors have prepared an analysis in which large volume, currently valueless material is recovered and recycled by chemical depolymerization. A careful selection of boundaries will reduce the amount of data needed to perform a meaningful life cycle assessment; however, it may also introduce new questions regarding the allocation of burdens. This paper will present the difficulties experienced in understanding the proper way to view burden allocation for a closed-loop system with limited boundaries.&lt;/div&gt;
The absence of SigX results in impaired carbon metabolism and membrane fluidity in Pseudomonas aeruginosa (2018)

In Pseudomonas aeruginosa, SigX is an extra-cytoplasmic function σ factor that belongs to the cell wall stress response network. In previous studies, we made the puzzling observation that sigX mutant growth was severely affected in rich lysogeny broth (LB) but not in minimal medium. Here, through comparative transcriptomic and proteomic analysis, we show that the absence of SigX results in dysregulation of genes, whose products are mainly involved in transport, carbon and energy metabolisms. Production of most of these genes is controlled by carbon catabolite repression (CCR), a key regulatory system than ensures preferential carbon source uptake and utilization, substrate prioritization and metabolism. The strong CCR response elicited in LB was lowered in a sigX mutant, suggesting altered nutrient uptake. Since the absence of SigX affects membrane composition and fluidity, we suspected membrane changes to cause such phenotype. The detergent polysorbate 80 (PS80) can moderately destabilize the envelope resulting in non-specific increased nutrient intake. Remarkably, growth, membrane fluidity and expression of dysregulated genes in the sigX mutant strain were restored in LB supplemented with PS80. Altogether, these data suggest that SigX is indirectly involved in CCR regulation, possibly via its effects on membrane integrity and fluidity.
Joint Beamforming and Clustering for Energy Efficient Multi-Cloud Radio Access Networks (2022)

The tremendous growth of data traffic in mobile communication networks (MCNs) and the associated exponential increase in mobile devices&#x2019; numbers necessitate the use of multi-cloud radio access networks (MC-RANs) as a viable solution to cope with the requirements of next-generation MCNs (6G). In MC-RANs, each central processor (CP) manages the signal processing of its own set of base stations (BSs), and so the system performance becomes a function of the joint intra-cloud and inter-cloud interference mitigation techniques. To this end, this paper considers the problem of maximizing the network-wide energy efficiency (EE) subject to user-to-cloud association, fronthaul capacity, maximum transmit power, and achievable rate constraints, so as to determine the joint beamforming vector of each user and the user-to-cloud association strategy. The paper tackles the non-convex and mixed discrete-continuous nature of the problem formulation using fractional programming (FP) and inner-convex approximation (ICA) techniques, as well as l<inf>0</inf>-norm relaxation heuristics, and shows how the proposed approach can be implemented in a distributed fashion via a reasonable amount of information exchange across the CPs. The paper simulations highlight the appreciable algorithmic efficiency of the proposed approach over state-of-the-art schemes.
A New Method For Numerical Constrained Optimization (2001)

Numerical constrained optimization is an important tool with extensive applications in computer graphics and many other diverse fields. In computer animation, for example, constrained optimization has been used for finding initial conditions, smoothing or finishing motion paths, interpolating orientations, animating flexible bodies, self-assembly of objects, and finding boundaries.
SDFS: Secure distributed file system for data-at-rest security for Hadoop-as-a-service (2015)

Cloud service providers are offering the popular Hadoop analytics platform following an "as-a-service" model, i.e. clusters of machines in their cloud infrastructures pre-configured with Hadoop software. Such offerings lower the cost and complexity of deploying a comparable system on-premises, however security considerations and in particular data confidentiality hamper wider adoption of such services by enterprises that handle data of sensitive nature. In this paper, we describe our efforts in providing security for data-at-rest (i.e. data that is stored) when Hadoop is offered as a cloud service. We analyze the requirements and architecture for such service and further describe a new distributed file system that we developed for Hadoop called SDFS, towards supporting this premise. We analyze parameter tuning for SDFS and through experiments on a real test-bed we evaluate its performance. We further present simulation results that explore the parameter space and can guide tuning.
General‐Purpose Control Devices (2005)

This chapter contains sections titled: Characteristics of General-Purpose Control Devices Programmable Controllers (Plcs) Numerical Controllers Robot Controllers References Bibliography
Access and Use of Social Networking Sites (SNSs) among the Post Graduate Students of Rural Based College of Tamil Nadu, India-A Study (2016)

Social Networking Sites (SNSs) are very useful to connect the people in today's society. The purpose of this study was to investigate the access to and use of social networking sites among the post graduate students of rural colleges in India. A questionnaire was used for this study. The respondents have excellent skills in using social networking sites for sharing and communicating information.
Essential oil composition of Callistemon viminalis leaves from India (2003)

Abstract The leaves of Callistemon viminalis , on hydrodistillation, gave 0.45% of an oil on a fresh weight basis. GC and GC–MS analysis of the oil resulted in the identiﬁcation of 42 constituents, representing 99.5% of the oil. 1,8‐Cineole (61.7%), α ‐pinene (24.2%) and menthyl acetate (5.3%) were the major components. Copyright © 2003 John Wiley &amp; Sons, Ltd.
Rapid measurement of transversal flow velocity vector with high spatial resolution using speckle decorrelation optical coherence tomography (2017)

We propose and demonstrate a novel method that uses only three sets of B-scans to accurately determine both the direction and the speed of a transversal flow using speckle decorrelation optical coherence tomography. Our tri-scan method has the advantages of high measurement speed, high spatial resolution, and insensitivity to the flow speed. By introducing error maps, we show that the flow angle inaccuracy can be minimized by choosing the measurement result with a lesser error between results obtained from the x- and y-scans. Finally, we demonstrate that the flow angle measurement accuracy can be further improved for the high-speed flows by increasing the speed of the x- and y-scans.
Preparation of Ferroelectric Thin Films Using Sol-Gel Solutions Dissolved in Supercritical Carbon Dioxide (2003)

A novel method to form ferroelectric thin films is presented, in which sol-gel solutions such as Bi2SiO5-added Bi4Ti3O12 (BIT) and Bi2SiO5-added SrBi2Ta2O9 (SBT) were dissolved in supercritical CO2 and ejected onto Pt-coated Si substrates in the atmosphere. The surface morphology of the deposited films was excellent even after crystallization annealing at 700°C for 30 min, and the remnant polarization values were 10 µC/cm2 and 7 µC/cm2 for BIT- and SBT-based films with 70 nm in thickness, respectively. It was also found that the leakage current depended on the post-annealing conditions; with increase of oxygen pressure during the annealing, the leakage current density was decreased to about 1.0 ×10-7 A/cm2.