gebhart/patrepeval huggingface dataset:
Structure elucidation of neutral, di-, tri-, and tetraglycosylceramides from High Five cells: identification of a novel (non-arthro-series) glycosphingolipid pathway (2005)

The major neutral glycosphingolipids (GSLs) of High Five insect cells have been extracted, purified, and characterized. It was anticipated that GSLs from High Five cells would follow the arthro-series pathway, known to be expressed by both insects and nematodes at least through the common tetraglycosylceramide (Glcbeta1Cer --> Manbeta4Glcbeta1Cer [MacCer] --> GlcNAcbeta3Manbeta4Glcbeta1Cer [At(3)Cer] --> GalNAcbeta4- GlcNAcbeta3Manbeta4Glcbeta1Cer [At(4)Cer]). Surprisingly, the structures of the major neutral High Five GSLs already diverge from the arthro-series pathway at the level of the triglycosylceramide. Studies by one- and two-dimensional nuclear magnetic resonance (NMR) spectroscopy and electrospray ionization mass spectrometry (ESI-MS) showed the structure of the predominant High Five triglycosylceramide to be Galbeta3Manbeta4Glcbeta1Cer, whereas the predominant tetraglycosylceramide was characterized as GalNAcalpha4Galbeta3Manbeta4- Glcbeta1Cer. Both of these structures are novel products for any cell or organism so far studied. The GalNAcalpha4 and Galbeta3 units are found in insect GSLs, but always as the fifth and sixth residues linked to GalNAcbeta4 in the arthro-series penta- and hexaglycosylceramide structures (At(5)Cer and At(6)Cer, respectively). The structure of the High Five tetraglycosylceramide thus requires a reversal of the usual order of action of the glycosyltransferases adding the GalNAcalpha4 and Galbeta3 residues in dipteran GSL biosynthesis and implies the existence of an insect Galbeta3-T capable of using Manbeta4Glcbeta1Cer as a substrate with high efficiency. The results demonstrate the potential appearance of unexpected glycoconjugate biosynthetic products even in widely used but unexamined systems, as well as a potential for core switching based on MacCer, as observed in mammalian cells based on the common LacCer intermediate.
EXAMINING TRADER BEHAVIOR IN IDEA MARKETS: AN IMPLEMENTATION OF GE'S IMAGINATION MARKETS (2012)

We present the outcome of an idea market run for one of GE Energy's sub-businesses in July and August of 2006. GE Energy used this market to elicit and rank-order technology and product ideas from across the sub-business. In this experiment, we examine the behavior of traders that have submitted the ideas on the market and their influence on the market's outcome. An idea’s submitter is clearly motivated to have his idea valued highly by the market, both by the funding given to the top idea as well as smaller prizes given to the top three ideas. In general, founders tended to buy their suggested ideas at prices above the volume-weighted-average-price (VWAP) in significant volumes. We discuss the implications and mitigation strategies. A survey of market participants yielded mixed results regarding the market's effectiveness at ranking ideas but very positive results regarding the quality of ideas proposed.
Heterogeneous Nano-structure and its Evolution in Heavily Cold-rolled SUS316LN Stainless Steels (2020)

Evolution of heterogeneous nano-structure in heavily cold-rolled SUS316LN stainless steels was investigated in detail. Transmission electron microscopic observations from the transverse direction (TD) of the 92% rolled specimen revealed the formation of a typical hetero-nano structure composed of ultra-fine lamellar grains embedded with deformation twin domains. The twin domains had prolate ellipsoidal shape elongated parallel to TD. Two types of twin domains with different crystallographical orientations to matrices could be identified, i.e., i) <211> // rolling direction (RD) and <110> // TD or ii) <110> // RD and <211> // TD, although all the {111} twining planes of both twin domains were oriented nearly parallel to the rolling planes. The ultra-fine lamellar grains were elongated along <100> direction and nearly parallel to RD. Deformation twins with a few nano-meter spacing were also frequently observed to develop in the lamellar grains. Evolution sequence of the hetero-nano structure during cold rolling was also investigated. At an early stage of rolling, deformation twins were gradually formed in the whole grains. Then, the regions fragmented grains by twins were further subdivided by a numerous number of shear bands inclined at about 20–45° from the RD, resulting in the formation of “eye-shaped” twin domains surrounded by shear bands and their crystallographical rotation. Cold rolling up to 50% caused a considerable increase in strength and decrease in ductility. While the strength was raised more with increasing reduction up to 92%, both the strength and ductility eventually slightly decreased by further rolling.
Bibliothèque de techniques d’optimisation de formes appliquée à la conception de circuits hyperfréquences (2013)

National audience
Studies on the constituents of useful plants. V. Multisubstituted flavones in the fruit peel of Citrus reticulata and their examination by gas-liquid chromatography. (1980)

Thirteen kinds of flavones, including two new flavones, were isolated from the fruit peel of Citrus reticulata BLANCO (Rutaceae) on the basis of thorough examination of the components in the chloroform extract of the peel. The structures of these flavones were confirmed by analysis of the spectral data and by structural conversion or total synthesis. β-Sitosterol, limonin, hesperidin, ferulic acid, and 5, 5'-oxydimethylene-bis(2-furaldehyde) were also isolated as components other than flavones. The multisubstituted flavones obtained were examined by gas-liquid chromatography, and may provide a good marker for chemotaxonomical studies of Citrus species.
Pilot-based Bayesian Channel Norm Estimation in Rayleigh Fading Multi-antenna Systems (2008)

Pilot-based estimation of the squared Euclidean norm of the channel vector of a Rayleigh fading system is considered. Unlike most previous work in the area of estimation of multiple antenna channels, we consider Bayesian estimation where the long-term channel statistics are known a priori. Closed-form expressions of the minimum mean square error (MMSE) estimator and its mean squared error (MSE) are derived for the cases of either an unweighted or a weighted unitary pilot matrix. The problem of finding the optimal pilot weighting, in the sense of minimizing the average MSE, is solved and a simple algorithm is proposed to achieve this power allocation numerically. The numerical evaluation shows that an optimal weighting can significantly improve the estimation quality in spatially correlated environments.
Electron trapping and impurity segregation without defects:Ab initiostudy of perfectly rebonded grain boundaries (1994)

We present the results of an extensive ab initio study of the \ensuremath{\Sigma}=5 tilt [310] grain boundary in germanium. We find that the boundary reliably reconstructs to the tetrahedrally bonded network observed in high-resolution electron microscopy experiments without the proliferation of false local minima observed in similar twist boundaries. The reduced density of bonds crossing the grain-boundary plane leads us to conjecture that the boundary may be a preferred fracture interface. Though there are no dangling bonds or miscoordinated sites in the reconstruction, the boundary presents electron-trap states just below the conduction band. Further, we show that lattice relaxation effects are irrelevant to the segregation of impurities to tetrahedrally reconstructed defects and that the interfacial electron-trap states give rise to an electronic frustration mechanism that selectively drives the segregation of only n-type dopants to the boundary.
Modifying the Directional Responses of a Coincident Pair of Microphones by Postprocessing (2008)

The proposed technique processes coincident or nearly coincident microphone stereo recordings to change the angle between and the width of the directional responses of the microphones effectively. Through this modification of the responses the width and spaciousness of the stereo recording can be controlled without introducing any artificial reverberation into the recording. The algorithm is based on prediction with the aim of controlling the amount of sound corresponding to the overlapping part of the microphone responses. It is shown how this processing relates to the effective directional responses of the processed signals. The results of a headphone-based subjective test indicate that the achieved audio waveform quality is very high and B-format derived coincident cardioid stereo recordings are improved significantly.
Inhibition of Expression of Natural UAG Suppressor Glutamine tRNA in HIV-Infected Human H9 Cells In Vitro by Avarol (1988)

HTLV-IIIB-infected H9 cells are shown to contain a high level of the natural UAG suppressor glutamine tRNA(UmUG Gln); this tRNA has been demonstrated to be required for the synthesis of Moloney murine leukemia virus (Mo-MuLV)-encoded protease. After cultivation of HTLV-IIIB-infected H9 cells with Avarol at a concentration (1 microgram/ml), previously found to protect the cells against the cytopathic effects of HTLV-III, an almost complete inhibition of the synthesis of the tRNA(UmUG Gln) was observed. Moreover, we obtained some evidence that the processing of the HTLV-III precursor protein p53 to p24 is inhibited by Avarol in infected cells, suggesting that the compound interferes with the expression of the viral protease gene.
Steering compensation for strong vertical refraction gradients in a long-distance free-space optical communication link over water (2005)

It is important to be able to characterize and compensate for refraction effects in free-space optical laser communication (FSO lasercom). The refractive index depends on various properties of the propagation medium such as temperature, pressure, and moisture, with temperature having the largest affect. Very strong but slow-varying thermal gradients have been observed at the NRL Chesapeake Bay lasercom testbed, which offers a 16 km one-way (32 km round-trip) FSO lasercom link over water. Thermal gradients affect the elevation-pointing angle, and their magnitudes are a function of the time of day and year and also the weather conditions. These vertical refraction errors are corrected by the use of a fiber positioner controlled by a position-sensing detector (PSD). This system is implemented into the receiver at the NRL Chesapeake Bay lasercom testbed. System test results will be presented.
Intranasal Prophylaxis with CpG Oligodeoxynucleotide Can Protect against Yersinia pestis Infection (2013)

Immunomodulatory agents potentially represent a new class of broad-spectrum antimicrobials. Here, we demonstrate that prophylaxis with immunomodulatory cytosine-phosphate-guanidine (CpG) oligodeoxynucleotide (ODN), a toll-like receptor 9 (TLR9) agonist, confers protection against Yersinia pestis, the etiologic agent of plague. The data establish that intranasal administration of CpG ODN 1 day prior to lethal pulmonary exposure to Y. pestis strain KIM D27 significantly improves survival of C57BL/6 mice and reduces bacterial growth in hepatic tissue, despite paradoxically increasing bacterial growth in the lung. All of these CpG ODN-mediated impacts, including the increased pulmonary burden, are TLR9 dependent, as they are not observed in TLR9-deficient mice. The capacity of prophylactic intranasal CpG ODN to enhance survival does not require adaptive immunity, as it is evident in mice lacking B and/or T cells; however, the presence of T cells improves long-term survival. The prophylactic regimen also improves survival and reduces hepatic bacterial burden in mice challenged intraperitoneally with KIM D27, indicating that intranasal delivery of CpG ODN has systemic impacts. Indeed, intranasal prophylaxis with CpG ODN provides significant protection against subcutaneous challenge with Y. pestis strain CO92 even though it fails to protect mice from intranasal challenge with that fully virulent strain.
An acoustically-linked deep-ocean observatory (2005)

A buoy-based observatory that uses acoustic communication to retrieve data from water column and seafloor instruments has been developed and deployed in 2362 m of water offshore Vancouver Island. The system uses high-rate (5000 bps) acoustic modems that are power-efficient (on order 1000 bits per joule) to telemeter data from an ocean bottom seismometer and a sensor monitoring a cold seep site near the Nootka fault. The buoy includes a Linux-based embedded controller, the modem base station and meteorological sensors. Data is off-loaded from the buoy using ftp, and remote login capability allows the acoustic communication schedule to be modified when instruments are added or removed from the network. The system has been operational for one year, typically transferring more than 500 Kbytes of data per day from two seafloor instruments.
EVIDENCE FOR THE EXISTENCE OF AN ALTERNATIVE B CELL DEVELOPMENT PATHWAY (B3) (2007)

Abstract During B-cell development rearrangement of immunoglobulin heavy and light chain genes occurs sequentially, separated by a pre-BCR checkpoint where the quality of the heavy chains is tested by pairing with a surrogate light chain (SLC). Here we demonstrate the existence of a second B-cell development pathway, that is characterized by a high expression of Sca1 and LFA1, is less dependent on SLC expression and does not have a late pre-B stage. This pathway becomes predominant with age and in conditions of lymphopenia, and is biased towards marginal zone B cells. However, cell fate switches occur between marginal zone and follicular B cells, likely to maintain marginal zone homeostasis. FO B cells derived directly from MZ B cells are distinguished by a higher expression of Sca1. Thus, an alternative, and perhaps ancestral, B-cell development pathway exists that is biased toward to the generation of MZ B cells.
Partition codes (2004)

We introduce the distance concept between two q-ary n-sequences, 2/spl les/q<n, called partition distance. This distance is a metric in the space of partitions of a finite n-set, where each partition contains /spl les/q disjoint subsets of the n-set. For the metric, we study codes called q-partition codes which can be applied to statistical analysis of psychological or sociological tests using questionnaires. A construction of q-partition codes based on the first order Reed-Muller codes is presented. A random coding bound is obtained.
Thymosin β4 was upregulated in recurred colorectal cancers (2013)

Recurrent cancers usually metastasise to other organs and have a very poor prognosis. Recurrence and metastatic spread have been proposed to depend on cancer stem cells, which express CD133.1

The expression of the actin-binding protein, thymosin β4 (Tβ4), has been reported to be elevated in a side population of small cells known as cancer stem cells in the breast cancer cell lines MCF7 and MDA-MB231.2 A recent study has also shown that colorectal cancer cells (CR-CSCs) from different patients that were sorted by CD133 had higher Tβ4 levels than normal colorectal cancer cells. Additionally, a lentiviral strategy to downregulate Tβ4 expression in CR-CSCs lowered the capacity of the cells to grow and migrate in culture, and reduced the tumour size and aggressiveness of CR-CSCs in xenografted mice.3 We have previously reported that Tβ4 levels in metastatic stomach cancers to the ovary were significantly upregulated compared with levels in normal stomachs and primary stomach cancers. Furthermore, Tβ4 expression was colocalised with CD133 expression in primary ovarian carcinomas, metastatic ovarian cancers from stomach cancers, and primary stomach cancers, suggesting that Tβ4 expression is strongly related to CD133 expression and is a characteristic of stem cells or cancer stem cells.4

In the present study, we compared the expression patterns of Tβ4 and CD133 in primary and recurrent colorectal cancer cells from the same patient. We obtained the paraffin-embedded primary and recurrent colorectal cancers of 10 patients. Tβ4 and CD133 expression …
Operation and control of large wind turbines and wind farms. Final report (2005)

This report is the final report of a Danish research project "Operation and control of large wind turbines and wind farms".The objective of the project has been to analyse and assess operational strategies and possibilities for control of different types of wind turbines and different wind farm concepts.
Multi-objective tradeoffs in the design optimization of a brushless permanent magnet machine with fractional-slot concentrated windings (2013)

In this paper, a robust parametric model of a brushless (BL) permanent magnet (PM) machine with fractional-slot concentrated windings (FSCW), which was developed for automated design optimization is presented. A computationally efficient-finite element analysis (CE-FEA) method was employed to estimate the dq-axes inductances, the induced voltage and torque ripple waveforms, and losses of the machine. A method for minimum effort calculation of the torque angle corresponding to the maximum torque per ampere (MTPA) load condition was developed. A differential evolution (DE) algorithm was implemented for the global design optimization with two concurrent objectives of minimum losses and minimum material cost. An engineering decision process based on the Pareto-optimal front for 3,500 candidate designs is presented together with discussions on the tradeoffs between cost and performance. One optimal design was finally selected, prototyped and tested.
Corrigendum to “Critical function of Ikaros in controlling Aiolos gene expression” [FEBS Lett. 581 (2007) 1605–1616] (2009)

An unfortunate error occurred in the top left panel of Fig. 4C . The correct panel is given below.
Study of Perovskite QD Down-Converted LEDs and Six-Color White LEDs for Future Displays with Excellent Color Performance (2016)

A narrow-emitting red, green, and blue (RGB) perovskite quantum dot (PeQD)-based tricolored display system can widen the color gamut over the National Television System Committee (NTSC) to 120%, but this value is misleading with regard to the color perception of cyan and yellow reproduced in the narrow RGB spectra. We propose that a PeQD-based six-color display system can reproduce true-to-life spectral distributions with high fidelity, widen the color gamut, and close the cyan and yellow gap in the RGB tricolored display by adding cyan (Cy), yellowish green (Yg), and orange colors (Or). In this study, we demonstrated pure-colored CsPbX3 (X = Cl, Br, I, or their halide mixtures; Cl/Br and Br/I) PeQD-based monochromatic down-converted light-emitting diodes (DC-LED) for the first time, and we incorporated PeQDs with UV-curable binders and long-wavelength-pass-dichroic filters (LPDFs). CsPbX3 PeQD-based pure Cy-, G-, Yg-, Or-, R-emitting monochromatic DC-LED provide luminous efficacy (LE) values of 81, 184, 79, 80, and 35 lm/W, respectively, at 20 mA. We also confirmed the suitability and the possibility of access to future color-by-blue backlights for field-sequential-color liquid crystal displays, using six-color multipackage white LEDs, as well as future six-colored light-emitting devices with high vision and color performance. The fabricated six-color multipackage white LEDs exhibited an appropriate LE (62 lm/W at total 120 mA), excellent color qualities (color rendering index (CRI) = 96, special CRI for red (R9) = 97) at a correlated color temperature (CCT) of 6500 K, and a wide color gamut covering the NTSC up to 145% in the 1931 Commission International de l'Eclairage (CIE) color coordinates space.
Alexia due to ischemic stroke of the visual word form area (2013)

The visual word form area (VWFA) is a region in the posterior left occipitotemporal cortex adjacent to the fusiform gyrus hypothesized to mediate word recognition. Evidence supporting the role of this area in reading comes from neuroimaging studies of normal subjects, case-controlled lesion studies, and studies of patients with surgical resection of the VWFA for tumors or epilepsy. Based on these prior reports, a small discrete lesion to the VWFA would be expected to cause alexia in a literate person without prior brain process, but such a case has not previously been reported to our knowledge. Here, we report the case of a previously-healthy 63-year-old man with the acute onset of alexia without other significant impairments. Magnetic resonance imaging (MRI) of the brain revealed a small ischemic stroke localized to the inferior left occipitotemporal cortex, corresponding to the approximate location of the putative VWFA. Characteristic of pure alexia, testing in the weeks following the stroke revealed a letter-by-letter reading strategy and a word length effect on single word reading. Formal visual field testing was normal. There was no color anomia, or object or face recognition deficits, although a mild agraphia may have been present. This case of acute-onset alexia in a previously normal individual due to a small stroke restricted to the VWFA and sparing occipital cortex and white matter pathways supports the conclusion that the VWFA is crucial for reading.
Clinical activity of the selective DRD2 antagonist ONC201, an imipridone, in metastatic endometrial cancer (mEC). (2017)

5592 Background: mEC is a generally incurable, with limited therapeutic options. ONC201 is the founding member of the new class of compounds called imipridones that are orally active small molecules. ONC201 a specific antagonist of the G protein-coupled receptor DRD2 exerts antitumor activity via a series of established signaling pathways (dual inhibition ERK/AKT, integrated stress response). DRD2 expression is elevated in malignant versus normal endometrial tissue. Furthermore ONC201 has shown anti-cancer activity in preclinical models of EC. Methods: In a Phase I trial that included an expansion cohort, a total of 28 evaluable patients (pts) were treated with ONC201 at doses from 125mg every 3 weeks to 625 weekly. Five of these patients had advanced mEC. Results: The median age for the mEC patients was 60 years (56-72), the median number of prior treatments was 5 (3-6), 3 patients had prior radiation and all patients had prior surgery. One patient received 375mg ONC201 while the other 4 patients received 625mg ONC201, orally every 3 weeks. The median number of doses was 3 (2-14). Two of 5 patients exhibited regressions in individual metastatic lesions, however they did not qualify as overall objective responses by RECIST criteria. One of these two patients experienced stable disease for 42 weeks. There were no reported SAEs and no Grade &gt; 1 AEs attributed to study drug. Conclusions: ONC201 is clinically active and well tolerated with oral administration in refractory mEC patients. Clinical trial information: NCT02250781. [Table: see text]
The Equilibrium Existence Duality: Equilibrium with Indivisibilities & Income Effects (2020)

We show that, with indivisible goods, the existence of competitive equilibrium fundamentally depends on agents' substitution effects, not their income effects. Our Equilibrium Existence Duality allows us to transport results on the existence of competitive equilibrium from settings with transferable utility to settings with income effects. One consequence is that net substitutability---which is a strictly weaker condition than gross substitutability---is sufficient for the existence of competitive equilibrium. We also extend the ``demand types'' classification of valuations to settings with income effects and give necessary and sufficient conditions for a pattern of substitution effects to guarantee the existence of competitive equilibrium.