gebhart/patrepeval huggingface dataset:
336-OR: A First-in-Human Single- and Multiple-Ascending Dose Study Evaluating Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Novel Oral Nonpeptide GLP-1 Receptor Agonist in Healthy Subjects (2022)

Background: LY3502970 (LY) is a novel, highly potent, orally bioavailable nonpeptide GLP-1 receptor agonist (RA) , and a potential alternative to injectable therapies or oral peptides whose absorption is affected by food or water intake. Objectives of this study were to evaluate safety, tolerability, pharmacokinetics (PK) , and pharmacodynamics (PD) of single and multiple doses of LY in healthy subjects. Methods: This was a multi-part, randomized, double-blind, phase 1 study (NCT03929744) . In Part A, subjects received placebo or single-dose LY with 5 cohorts receiving escalating doses. In Part B, subjects received 4 weeks of daily placebo or repeated oral LY escalating weekly to 5 different final target doses. Overtly healthy adults 18-65 yrs old with body mass index 20-40 kg/m2 and A1c &amp;lt;6.5% were eligible. Results: Of 133 subjects enrolled, 32 participated in Part A (mean age 43.4 yrs) and 60 participated in Part B (mean age 42.5 yrs) . There were no deaths or serious adverse events. Most common (occurring in ≥3 subjects) treatment-emergent adverse events in Part A were vomiting, nausea, and headache, and in Part B were nausea, headache, and constipation. PK was approximately proportional; mean Cmax in Part A was 1.4-14.9 ng/mL and mean t½ was 24.6-35.3 hrs across the dose range after single dose. In Part B, mean Cmax was 11.1-99.6 ng/mL and mean t½ was 48.1-67.5 hrs on Day 28 across the dose range. Single and repeated doses of LY decreased mean fasting glucose compared to baseline across Days 1-28. In Part B, significant reductions in body weight from baseline were observed after 4 weeks in 4 cohorts (except for the lowest dose) . Gastric emptying was delayed after initial LY dose but was no longer evident at Day 28. Conclusion: This oral nonpeptide had safety and PD marker profiles similar to injectable GLP-1 RAs and PK enabling once daily dosing. These data support further clinical development. Disclosure E.J.Pratt: Employee; Eli Lilly and Company. X.Ma: Employee; Eli Lilly and Company, Stock/Shareholder; Eli Lilly and Company. R.Liu: Employee; Eli Lilly and Company. D.A.Robins: Employee; Eli Lilly and Company. K.Sloop: Employee; Eli Lilly and Company. C.Benson: None.
Functional Aptamers and Aptazymes in Biotechnology, Diagnostics, and Therapy (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A TriMedia based multi-processor system using PCI technology for immersive videoconference terminals (2003)

This paper introduces newly developed hardware components and configuration aspects for a complex video-processing system based on PCI (Peripheral Component Interconnect) architectures. Originally designed for an immersive videoconference system, the modular, scalable and cost efficient multi-processor structure can also be applied to other demanding signal processing applications. Announcing the videoconference system, the structure of a PCI subsystem based on four TriMedia processors and an open interface architecture is derived and explained. First application results of the introduced components are presented regarding PCI compatibility, processing power as well as the system architecture.
Improvement in Positioning Accuracy of Light-Induced Self-Written Polymeric Optical Waveguide Using an “Optical Solder” Effect (2006)

Improvements in the positioning accuracy of light-induced self-written (LISW) polymeric optical waveguides at the end face of optical modules have been realized by using an "optical solder" effect and a simply-designed enclosure socket. The LISW waveguides were fabricated by irradiation through two faceted fibers. The fiber ends are set at certain mounting positions with respect to the light-emitting diodes and photo diodes. The resulting positional accuracy at the extremities of the optical waveguides is less than one-tenth of the optical fiber core diameter. This value is sufficiently accurate to realize passive alignment.
Determination of phenylthiohydantoin-amino acids by two-step laser desorption/multiphoton ionization (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of phenylthiohydantoin-amino acids by two-step laser desorption/multiphoton ionizationFriedrich. Engelke, Jong Hoon. Hahn, Wolfgang. Henke, and Richard N. ZareCite this: Anal. Chem. 1987, 59, 6, 909–912Publication Date (Print):March 15, 1987Publication History Published online1 May 2002Published inissue 15 March 1987https://pubs.acs.org/doi/10.1021/ac00133a026https://doi.org/10.1021/ac00133a026research-articleACS PublicationsRequest reuse permissionsArticle Views205Altmetric-Citations93LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Safety, efficacy, and immunogenicity of a recombinant Osp subunit canine Lyme disease vaccine (1996)

A subunit canine Lyme disease vaccine formulated with recombinant lipidated Osp A and OspB and saponin QS21 was assessed for safety, protective efficacy, and immunogenicity. Ten normal beagles were subcutaneously vaccinated twice at age 12 and 16 weeks, respectively. Three months after the second vaccination, the vaccinates and another 10 nonvaccinated control beagles were challenged by feeding ticks on each dog for 5 days using eight field-collected adult female and six adult male Ixodes scapularis infected with Lyme disease spirochetes per dog. Adverse reactions associated with the vaccinations were limited to injection site swellings which occurred within the first 48 h and resolved within a week. The local reaction was independent of vaccination times and tick challenge. On the basis of typical clinical signs, xenodiagnosis, and diagnostic immunoblotting, all 10 controls were infected; five developed lameness and three of them experienced at least two to three episodes of limping during a 10-month monitoring period. In contrast, eight of ten vaccinates were protected and two infected vaccinates, as judged by xenodiagnosis, were asymptomatic. None of the protected vaccinates developed antibodies to diagnostic spirochetal antigens other than OspA and OspB. In contrast, most controls produced antibodies to borrelial antigens, but not to OspA and OspB. Antibody production in vaccinates receiving a third vaccination 10 months postchallenge was greatly boosted; the geometric mean antibody titer was significantly higher (P < 0.0001) than that tested prechallenge. Thus, the subunit canine Lyme disease vaccine was safe and protective and elicited immunological memory. Vaccinated dogs were serologically distinguishable from those naturally exposed.
Predicting severity in COVID-19 disease using sepsis blood gene expression signatures (2023)

Severely-afflicted COVID-19 patients can exhibit disease manifestations representative of sepsis, including acute respiratory distress syndrome and multiple organ failure. We hypothesized that diagnostic tools used in managing all-cause sepsis, such as clinical criteria, biomarkers, and gene expression signatures, should extend to COVID-19 patients. Here we analyzed the whole blood transcriptome of 124 early (1-5 days post-hospital admission) and late (6-20 days post-admission) sampled patients with confirmed COVID-19 infections from hospitals in Quebec, Canada. Mechanisms associated with COVID-19 severity were identified between severity groups (ranging from mild disease to the requirement for mechanical ventilation and mortality), and established sepsis signatures were assessed for dysregulation. Specifically, gene expression signatures representing pathophysiological events, namely cellular reprogramming, organ dysfunction, and mortality, were significantly enriched and predictive of severity and lethality in COVID-19 patients. Mechanistic endotypes reflective of distinct sepsis aetiologies and therapeutic opportunities were also identified in subsets of patients, enabling prediction of potentially-effective repurposed drugs. The expression of sepsis gene expression signatures in severely-afflicted COVID-19 patients indicates that these patients should be classified as having severe sepsis. Accordingly, in severe COVID-19 patients, these signatures should be strongly considered for the mechanistic characterization, diagnosis, and guidance of treatment using repurposed drugs.
Study of Design Optimization Method for Ultra-Low Power Micro Gas Sensor (2019)

In this paper, we propose a design optimization scheme of metal oxide gas sensor with suspended beams. Our design scheme comprises two parts, design of suspended membrane and beam membrane, and design of heater geometry. These processes are based on mathematical analysis. In the suspended membrane and beam design, power consumption at steady state and transient state as well as response speed of microheater are considered. In the heater geometry design, a mathematical method for realizing an arbitrary temperature profile is proposed. After these steps, the electro-thermal performance and the mechanical properties of the suggested designs are investigated by finite element analysis. Here, we demonstrated this scheme for designing gas sensors with two suspended beams. Calculated design operates at 388 °C with 7.88 mW power consumption and have uniform temperature profile. In addition, the relation between the dimensions of suspended beams and their mechanical properties has been investigated. By utilizing our scheme, design process of low-power gas sensors satisfying constraints on mechanical properties and footprint can be rapidly obtained.
A Stochastic Framework for Scheduling in Wireless Packet Access Networks (2007)

We put forth a unified framework for downlink and uplink scheduling of multiple connections with diverse quality-of-service requirements, where each connection transmits using adaptive modulation and coding over a wireless fading channel. Based on quantized channel state information at the transmitters (Q-CSIT), we derive the information-theoretic optimal downlink and uplink resource allocation/scheduling strategies using tools from convex/nonlinear optimization theory. When the fading statistics are not known a priori, we develop a class of stochastic primal-dual (SPD) algorithms which can dynamically adapt the scheduling policies online. We prove rigorously and confirm by simulations that with affordable complexity, these SPD algorithms asymptotically converge to the optimal scheduling strategies from any initial value.
Green-Routed Carbon Dot-Adorned Silver Nanoparticles for the Catalytic Degradation of Organic Dyes (2022)

Herein, a simple, cost-effective, and in-situ environmentally friendly approach was adopted to synthesize carbon dot-adorned silver nanoparticles (CDs@AgNPs) from yellow myrobalan (Terminalia chebula) fruit using a hydrothermal treatment without any additional reducing and or stabilizing agents. The as-synthesized CDs@AgNP composite was systematically characterized using multiple analytical techniques: FESEM, TEM, XRD, Raman, ATR-FTIR, XPS, and UV-vis spectroscopy. All the results of the characterization techniques strongly support the idea that the CDs were successfully made to adorn the AgNPs. This effectively synthesized CDs@AgNP composite was applied as a catalyst for the degradation of organic dyes, including methylene blue (MB) and methyl orange (MO). The degradation results revealed that CDs@AgNPs exhibit a superior catalytic activity in the degradation of MB and MO in the presence of NaBH4 (SB) under ambient temperatures. In total, 99.5 and 99.0% rates of degradation of MB and MO were observed using CDs@AgNP composite with SB, respectively. A plausible mechanism for the reductive degradation of MB and MO is discussed in detail. Moreover, the CDs@AgNP composite has great potential for wastewater treatment applications.
Advanced Washcoat Technology for PZEV Application (2008)

&lt;div class="htmlview paragraph"&gt;In recent years, automobile emission limits have been tightened world wide. PZEV (Partial Zero Emission Vehicle) which is the most stringent regulation has been imposed in California. To meet the strict PZEV regulation, automotive manufacturers are requesting the catalyst system to have quick light-off characteristics and excellent steady state performance with limited precious group metals (PGM) usage due to the strong price pressure. Moreover, the catalyst can not use high cell density substrate for increasing geometric surface area and reducing heat mass, since the backpressure of exhaust system must be decreased to improve the vehicle power for the PZEV application. This paper will present an efficient catalyst formulation that has been designed to maximize the performance with considerably reduce PGM loading. The catalyst washcoat has been optimized by improving the catalyst geometric surface area, gas diffusivity and thermal mass. The catalyst material was also optimized by enhancing thermal stability and oxygen storage capacity (OSC). The developed catalyst system exhibited superior performance to the previous catalyst developed for the 2006 model year vehicle. The final catalyst system represents a PGM usage that is 50% lower than that of the previous generation.&lt;/div&gt;
Imaging glial activation in patients with post-treatment Lyme disease symptoms: a pilot study using [11C]DPA-713 PET (2018)

The pathophysiology of post-treatment Lyme disease syndrome (PTLDS) may be linked to overactive immunity including aberrant activity of the brain's resident immune cells, microglia. Here we used [<sup>11</sup>C]DPA-713 and positron emission tomography to quantify the 18 kDa translocator protein, a marker of activated microglia or reactive astrocytes, in the brains of patients with post-treatment Lyme disease symptoms of any duration compared to healthy controls. Genotyping for the TSPO rs6971 polymorphism was completed, and individuals with the rare, low affinity binding genotype were excluded. Data from eight brain regions demonstrated higher [<sup>11</sup>C]DPA-713 binding in 12 patients relative to 19 controls. [<sup>11</sup>C]DPA-713 PET is a promising tool to study cerebral glial activation in PTLDS and its link to cognitive symptoms.
A balanced approach to high-level verification: performance trade-offs in verifying large-scale multiprocessors (2002)

A single node of a modern scalable multiprocessor consists of several ASICs comprising tens of millions of gates. This level of integration and complexity imposes an enormous onus on the verification process. A variety of tools, ranging from discrete-event logic simulation to formal model checking, can be used to attack this problem. Unfortunately, conventional simulation techniques, with their primitive interface to the hardware (i.e. test vectors), are inadequate tools for reasoning about the correctness of complex architectural features, such as cache coherence protocols and memory consistency models. Similarly, model checkers offer very limited utility on such large designs. We have previously proposed a novel verification framework, called Raven, that addresses many of these challenges. In this paper we examine the performance implications of verifying systems at higher levels of abstraction. A detailed performance analysis is conducted to compare this higher-level approach against an equivalent Verilog test bench. We establish lower and upper bounds on the performance of the Raven environment executing on a single-processor on a set of distributed processors, and on a shared-memory multiprocessor.
Fast frequency hopping diversity scheme for OFDM-based UWB systems (2007)

The application of the well-known fast frequency hopping (FFH) scheme to the WIMEDIA OFDM-based UWB standard is presented. A promising packed error ratio performance was found. The proposed novel WIMEDIA FFH/OFDM scheme outperforms the regular scheme by up to 5 dB, and in combination with an ultra-sparse-(U-S)-LDPC code, up to 7 dB. Even uncoded transmission is conceivable, paving the way towards low complex ultra-high data rate systems.
β-Arrestin-1 Competitively Inhibits Insulin-Induced Ubiquitination and Degradation of Insulin Receptor Substrate 1 (2004)

beta-arrestin-1 is an adaptor protein that mediates agonist-dependent internalization and desensitization of G-protein-coupled receptors (GPCRs) and also participates in the process of heterologous desensitization between receptor tyrosine kinases and GPCR signaling. In the present study, we determined whether beta-arrestin-1 is involved in insulin-induced insulin receptor substrate 1 (IRS-1) degradation. Overexpression of wild-type (WT) beta-arrestin-1 attenuated insulin-induced degradation of IRS-1, leading to increased insulin signaling downstream of IRS-1. When endogenous beta-arrestin-1 was knocked down by transfection of beta-arrestin-1 small interfering RNA, insulin-induced IRS-1 degradation was enhanced. Insulin stimulated the association of IRS-1 and Mdm2, an E3 ubiquitin ligase, and this association was inhibited to overexpression of WT beta-arrestin-1, which led by decreased ubiquitin content of IRS-1, suggesting that both beta-arrestin-1 and IRS-1 competitively bind to Mdm2. In summary, we have found the following: (i) beta-arrestin-1 can alter insulin signaling by inhibiting insulin-induced proteasomal degradation of IRS-1; (ii) beta-arrestin-1 decreases the rate of ubiquitination of IRS-1 by competitively binding to endogenous Mdm2, an E3 ligase that can ubiquitinate IRS-1; (iii) dephosphorylation of S412 on beta-arrestin and the amino terminus of beta-arrestin-1 are required for this effect of beta-arrestin on IRS-1 degradation; and (iv) inhibition of beta-arrestin-1 leads to enhanced IRS-1 degradation and accentuated cellular insulin resistance.
Waveguide and photonic crystal design of photonic crystal surface-emitting laser (2015)

980 nm GaAs-based photonic crystal surface emitting lasers containing all semiconductor GaAs/InGaP and GaAs/air photonic crystals (PC) inside their cavity are theoretically investigated. We use a combination of an average index approach and optical coupled mode theory to optimize the PC interaction with optical modes of the laser waveguide and draw guidelines for design of PCSELs based on a range of material systems and operating wavelengths. Results show that the all-semiconductor PC provides a higher coupling with the optical mode in most cases.
The effect of deep trench and sub-collector on the latchup robustness in BiCMOS silicon germanium technology (2004)

This paper demonstrates the influence and improvement of deep trench (DT) isolation, and bipolar sub-collector on CMOS latchup in a 0.13 /spl mu/m CMOS-based 200/285 GHz (f/sub T//f/sub max/) SiGe HBT technology.
Two-photon excited fluorescence of intrinsic fluorophores enables label-free assessment of adipose tissue function (2016)

Current methods for evaluating adipose tissue function are destructive or have low spatial resolution. These limit our ability to assess dynamic changes and heterogeneous responses that occur in healthy or diseased subjects, or during treatment. Here, we demonstrate that intrinsic two-photon excited fluorescence enables functional imaging of adipocyte metabolism with subcellular resolution. Steady-state and time-resolved fluorescence from intracellular metabolic co-factors and lipid droplets can distinguish the functional states of excised white, brown, and cold-induced beige fat. Similar optical changes are identified when white and brown fat are assessed in vivo. Therefore, these studies establish the potential of non-invasive, high resolution, endogenous contrast, two-photon imaging to identify distinct adipose tissue types, monitor their functional state, and characterize heterogeneity of induced responses.
Natural unidirectional sheet processes for fibre reinforced bioplastics (2017)

Technical natural fibre semi-finished products are mainly used in lightweight automotive components as random fiber mats which are often combined with petrochemical matrix resins for large series production process. However, random fiber arrangement and limited fiber length restrain the complete utilization of the material-inherent strength reserves of natural fibers. With high-levels of petroleum-based plastics (about 20-50 wt -%) in the structure, these applications have a clear potential in terms of eco-friendliness and sustainability. The development of new fully bio-based composites and efficient manufacturing methods suitable for series processing is the purpose of the current sub-project C4 “Flexible textile / plastics processes with renewable raw materials” in the framework of the Excellence Cluster MERGE EXC 1075, funded by DFG (Deutsche Forschungsgemeinschaft). A high-efficiency in terms of mass-production, reproducibility and flexibility requires the performance of successive steps in the manufacture of semi-finished and final products. The appropriate process line comprises the steps of the preparation of the thermoplastic matrix sheets (such as from Bio-polyethylene or Bio-polyamide) and a specific chemical modification of the reinforcing materials (wood veneer and unidirectional flax fibers) on the concept of a discontinuous or continuous production of unidirectional reinforced Natural Fibre Composites (NFC) prepregs. Moreover, the shaping of hybrid lightweight structures from NFC prepregs makes possible the incorporation of these innovative technologies into new concepts and potential applications in several fields such as automotive industry or sport equipment. The mechanical properties profile of the flax - natural unidirectional sheet for fibre reinforced bioplastics has been here studied in detail with press-engineered samples and has confirmed their high application potential as an alternative to glass fiber-reinforced composite sheets.