gebhart/patrepeval huggingface dataset:
A Neutrally Charged Trimethylmanganese(III) Complex: Synthesis, Characterization, and Disproportionation Chemistry (2016)

The synthesis and properties of an unusual, neutrally charged and volatile N,N,N′,N′-tetramethylethylenediamine trimethyl manganese(III) complex, (TMEDA)MnMe3, are described, along with its facile disproportionation to the corresponding Mn(II) and Mn(IV) complexes. Characterization by single-crystal XRD, UV–vis spectroscopy, high-frequency and -field EPR (HFEPR), magnetic susceptibility, and density functional theory (DFT) computations indicate that the (TMEDA)MnMe3 electronic structure can be described as largely square pyramidal Mn(III) centered. The paucity of manganese(III) polyalkyls and the simplicity and reactivity of this compound implicate it as a potentially useful synthetic building block.
TORA example: cascade and passivity control designs (2005)

Considers the problem of feedback stabilization of translational oscillations by a rotational actuator (TORA system). The authors present several controller designs based on the cascade and passivity paradigms.
Demethylation of Aromatic Methyl Ethers Using Ionic Liquids under Microwave Irradiation (2011)

An efficient demethylation reaction for aromatic methyl ethers has been developed. Deprotection reactions give high yields with butylpyridinium bromide under microwave irradiation. Basic and acidic functional groups are tolerated if the reaction is performed under acidic conditions. Keywords: Aromatic ether, demethylation, ionic liquid, microwave irradiation, solvent free
Impact of Catheter Ablation of the Coronary Sinus on Paroxysmal or Persistent Atrial Fibrillation (2007)

Catheter ablation targeting both the endocardial and epicardial aspects of the CS region significantly prolongs fibrillatory cycle length and terminates AF persisting after PV isolation in 35% of patients.
DNA damage induces cdk2 protein levels and histone H2B phosphorylation in SH-SY5Y neuroblastoma cells (2005)

DNA damage and activation of the cell cycle have been implicated in numerous neurodegenerative diseases, including Alzheimer disease, Parkinson's disease, and amyotrophic lateral sclerosis. To better understand the role of cell cycle proteins in DNA-damage induced neuronal cell death, we examined various cell cycle proteins during camptothecin-induced death of human neuroblastoma cells. We report a rapid induction of p53 and increased expression of p21, concurrent with reduced levels of many cell cycle proteins that regulate G1 to S phase cell cycle progression. However, we found increased levels of cdk2 and cyclin E, and formation of a cyclin E-cdk2-p21 protein complex. DNA damage failed to induce activation and progression of the cell cycle. Finally, camptothecin-induced neuronal cell death occurred concurrent with phosphorylation of histone H2B. Pretreatment of cells with cdk inhibitor olomoucine impeded cdk2-cyclin E accumulation, but not the induction of p53. Olomucine concurrently delayed histone H2B phosphorylation, caspase-3 activation and cell death. These findings suggest that DNA-damage of differentiated neuroblastoma cells induces a rapid p53-mediated inhibition of cell cycle progression and induction of cdk2-cyclin E, followed by caspase-3 activation, phosphorylation of histone and cell death.
N-Face Metal–Insulator–Semiconductor High-Electron-Mobility Transistors With AlN Back-Barrier (2008)

We present a high-performance SiN/AlGaN (cap)/GaN (channel)/AlN (barrier)/GaN (buffer) metal-insulator-semiconductor high-electron-mobility transistor grown on the N-face, in which the 2-D electron gas (2DEG) is induced at the top GaN/AlN interface. The use of AlN eliminates alloy disorder scattering to the 2DEG and provides strong back-barrier confinement of the 2DEG under high electric fields for device scaling. Devices with 0.7-mum gate length showed a current-gain cutoff frequency ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">fT</i> ) of 17 GHz and a power-gain cutoff frequency ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">max</sub> ) of 37 GHz. A continuous-wave output power density of 7.1 W/mm was measured at 4 GHz, with 58% power-added efficiency and a large-signal gain of 15.3 dB at a drain bias of 35 V.
Early load address resolution via register tracking (2000)

Higher microprocessor frequencies accentuate the performance cost of memory accesses. This is especially noticeable in the Intel's IA32 architecture where lack of registers results in increased number of memory accesses. This paper presents novel, non-speculative technique that partially hides the increasing load-to-use latency, by allowing the early issue of load instructions. Early load address resolution relies on register tracking to safely compute the addresses of memory references in the front-end part of the processor pipeline. Register tracking enables decode-time computation of register values by tracking simple operations of the form reg±immediate. Register tracking may be performed in any pipeline stage following instruction decode and prior to execution.
Trends of Presentation and Clinical Outcome of Treated Renal Angiomyolipoma (2010)

Significant differences in clinical manifestations and treatment outcomes were noted in respect to tumor characteristics, association with TSC, and treatment modality. Considering the benign nature of AML, these parameters ought to be considered when deciding upon active surveillance or prophylactic intervention.
REAL-TIME ENVIRONMENTAL INFORMATION NETWORK AND ANALYSIS SYSTEM: PHASE IV.FINAL (1995)

The Real-Time Environmental Information Network and Analysis System (REINAS) is a continuing engineering research and development program with the goal of designing, developing and testing an operational prototype system for data acquisition, data management, and visualization. This system is to support the real-time utilization of advanced instrumentation in environmental science. Current applications are in meteorology and oceanography; others envisioned include geophysics, hydrology, air pollution, etc. The REINAS project has been funded by a Department of Defense University Research Initiative through the Office of Naval Research. Participating institutions include the Naval Postgraduate School (NPS), the Monterey Bay Aquarium Research Institute (MBARI) and the Baskin Center for Computer Engineering and Information Sciences of the University of California, Santa Cruz (UCSC). The REINAS system has been designed for regional real-time environmental monitoring and analysis. It is a modern system, integrated into the Internet, for conducting interactive real-time coastal air/ocean science. The database design of REINAS is independent of specific database technology and is designed to support operational scientific needs throughput the entire scientific data life-cycle. During the previous phases a survey of available technologies was made, selections of the those to be used in the prototype system were made, and detailed architecture of REINAS and experimentation with subsystems for data collection, data management, processing, and visualization were started. This report documents the status of REINAS in Phase IV -- the Experimentation and System Verification Phase.
Nonlinear Near-Field Optical Effects of the AgOx-Type Super-Resolution Near-Field Structure (2003)

AgOx-type super-resolution near-field structure (Super-RENS) exhibits nonlinear near-field optical behavior in the near field, which is closely related to the subwavelength resolution capability of the Super-RENS disk. Finite-difference time-domain (FDTD) numerical simulations were used to demonstrate that these nonlinear effects may result from collective localized surface plasmons of silver nanoparticles.
Enhanced Re-Endothelialization of Decellularized Rat Lungs (2016)

Decellularized lung tissue has been recognized as a potential platform to engineer whole lung organs suitable for transplantation or for modeling a variety of lung diseases. However, many technical hurdles remain before this potential may be fully realized. Inability to efficiently re-endothelialize the pulmonary vasculature with a functional endothelium appears to be the primary cause of failure of recellularized lung scaffolds in early transplant studies. Here, we present an optimized approach for enhanced re-endothelialization of decellularized rodent lung scaffolds with rat lung microvascular endothelial cells (ECs). This was achieved by adjusting the posture of the lung to a supine position during cell seeding through the pulmonary artery. The supine position allowed for significantly more homogeneous seeding and better cell retention in the apex regions of all lobes than the traditional upright position, especially in the right upper and left lobes. Additionally, the supine position allowed for greater cell retention within large diameter vessels (proximal 100-5000 μm) than the upright position, with little to no difference in the small diameter distal vessels. EC adhesion in the proximal regions of the pulmonary vasculature in the decellularized lung was dependent on the binding of EC integrins, specifically α1β1, α2β1, and α5β1 integrins to, respectively, collagen type-I, type-IV, and fibronectin in the residual extracellular matrix. Following in vitro maturation of the seeded constructs under perfusion culture, the seeded ECs spread along the vascular wall, leading to a partial reestablishment of endothelial barrier function as inferred from a custom-designed leakage assay. Our results suggest that attention to cellular distribution within the whole organ is of paramount importance for restoring proper vascular function.
Data Organization and Databases (2001)

This chapter contains sections titled: 12.1 Introduction, 12.2 Memory Hierarchy, 12.3 Index Structures, 12.4 Multidimensional Indexing, 12.5 Relational Databases, 12.6 Manipulating Tables, 12.7 The Structured Query Language (SQL), 12.8 Query Execution and Optimization, 12.9 Data Warehousing and Online Analytical Processing (OLAP), 12.10 Data Structures for OLAP, 12.11 String Databases, 12.12 Massive Data Sets, Data Management, and Data Mining, 12.13 Further Reading
Adhesive Interactions and the Patterning of Nerve Connections: An Experimental and Theoretical Approach (1987)

Adhesive interactions have long been proposed to play a central role in the patterning of neural structures and their interconnections. Many of these ideas are based upon experiments on the projection from the eye to the optic tectum (the retinotectal projection) in lowervertebrates. In order to test the feasibility of such proposals, a detailed model, based largely on adhesive interactions between cells, has been developed. Computer simulations of the modelshow that simple adhesive interactions are sufficient to explain much of the literature on the patterning of the amphibian retinotectal projection. Aspects of the model have been experimetally tested through the use of antibodies to known adhesive molecules. The results of these experiments appear consistent with the role of adhesion in the patterning of the connections and with the predictions of the model. Although such experiments demonstrate the power of adhesive cell interactions in the patterning of nerve connections, additional experiments and simulations demonstrate that some other non-adhesive processes may play a role. In particular, the addition of a process that is dependent on the activity of the neurons allows the model to better fit the literature. An activity-dependent competition between neurons for adhesive sites on the target cells appears to be sufficient to play this role.
Electrochemically in-situ synthesized DNA probe arrays (2015)

status: Published
A macrophage-like cell model for testing anti-CMV drugs. (1997)

Monocyte/macrophage cells can be infected with human cytomegalovirus (HCMV) and could be a reservoir and a vehicle for virus spread in infected patients. The monocytic-like cell line THP-1 differentiated along the monocyte pathway with a phorbol ester (phorbol 12-myristate 13-acetate, PMA) for 24h was infected with cell free-supernatant of Towne CMV-strain infected fibroblasts MRC-5. We designed experiments to study the replication of HCMV in PMA treated THP-1 cells, exposed to DHPG (Cymevan, ganciclovir, Syntex). We incubated PMA treated THP-1 cells with DHPG for one to five days at 37 degrees C before or after the infection. The cells were cultivated for 5 days at 37 degrees C then supernatants of culture were collected and they were added to fibroblast cultures. The infection of the fibroblasts was studied on the basis of immune detection of viral immediate early antigens (IEA) in nucleus 24h after culture. Incubation of infected THP-1 cells with 11.1 microM DHPG for 5 days at 37 degrees C resulted in 95 +/- 2% inhibition of the replication whereas incubation of the infected cells with the same concentration of DHPG for two days resulted in 50 +/- 5% inhibition. Pretreatment of cells with DHPG for 5 days induced a 50 +/- 4% decrease of the level of infectious particles produced by HCMV infected cells. This is the first report of the antiviral effect of DHPG in macrophagic-like cells.
Cellular and Humoral Immune Responses after Immunisation with Low Virulent African Swine Fever Virus in the Large White Inbred Babraham Line and Outbred Domestic Pigs (2022)

African swine fever virus is currently present in all of the world's continents apart from Antarctica, and efforts to control the disease are hampered by the lack of a commercially available vaccine. The Babraham large white pig is a highly inbred line that could represent a powerful tool to improve our understanding of the protective immune responses to this complex pathogen; however, previous studies indicated differential vaccine responses after the African swine fever virus challenge of inbred minipigs with different swine leukocyte antigen haplotypes. Lymphocyte numbers and African swine fever virus-specific antibody and T-cell responses were measured in inbred and outbred animals after inoculation with a low virulent African swine fever virus isolate and subsequent challenge with a related virulent virus. Surprisingly, diminished immune responses were observed in the Babraham pigs when compared to the outbred animals, and the inbred pigs were not protected after challenge. Recovery of Babraham pigs after challenge weakly correlated with antibody responses, whereas protective responses in outbred animals more closely correlated with the T-cell response. The Babraham pig may, therefore, represent a useful model for studying the role of antibodies in protection against the African swine fever virus.
The 65-nm 16-MB Shared On-Die L3 Cache for the Dual-Core Intel Xeon Processor 7100 Series (2007)

The 16-way set associative, single-ported 16-MB cache for the Dual-Core Intel Xeon Processor 7100 Series uses a 0.624 mum <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> cell in a 65-nm 8-metal technology. Low power techniques are implemented in the L3 cache to minimize both leakage and dynamic power. Sleep transistors are used in the SRAM array and peripherals, reducing the cache leakage by more than 2X. Only 0.8% of the cache is powered up for a cache access. Dynamic cache line disable (Intel Cache Safe Technology) with a history buffer protects the cache from latent defects and infant mortality failures
Seeing the Stars in Broad Daylight—Nanotechnology Solutions To Reduce Noise in Chemical Sensing (2017)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTSeeing the Stars in Broad Daylight—Nanotechnology Solutions To Reduce Noise in Chemical SensingMichael J. SailorView Author Information University of California, San Diego, California 92093, United StatesCite this: ACS Sens. 2017, 2, 2, 190Publication Date (Web):February 24, 2017Publication History Received8 February 2017Published online24 February 2017Published inissue 24 February 2017https://pubs.acs.org/doi/10.1021/acssensors.7b00079https://doi.org/10.1021/acssensors.7b00079editorialACS PublicationsCopyright © 2017 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views895Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (322 KB) Get e-AlertscloseSUBJECTS:Filtration,Molecules,Nanopores,Nanotechnology,Sensors Get e-Alerts
Abstract LB-313: Development of a non-invasive, multi-analyte assay for the triage of patients presenting with hematuria (2011)

Abstract Introduction The presence of blood in the urine (hematuria) is one of the hallmark symptoms of bladder cancer. Thus, the current best practice policy suggests that patients with hematuria undergo cystoscopic examination. However, hematuria can be present in healthy individuals as well as in individuals with various non-life threatening conditions such that a majority of patients with blood in the urine (∼95%) who are screened by cystoscopy do not have bladder cancer. In addition, recent studies have found that a majority of patients with hematuria are not referred on to a specialist for further invasive tests, despite the guidelines. This suggests that the prevalence of cancer in this population may be lower than 5%, making screening by cystoscopy inefficient and, in a large number of cases, unnecessary. We are developing a non-invasive diagnostic assay utilizing urinary protein and DNA biomarkers to triage those patients who do not have cancer from those who should go on to be existing invasive screening modalities. Methods Urine samples were obtained from 48 cancer patients and 256 patients who were evaluated for hematuria but who did not have cancer upon cystoscopic evaluation (Hem+/Cysto−). Twist1 and Nid2 methylation status was assessed using methylation-specific PCR primers and FGFR3 mutational status was determined by quantitative PCR. Matrix Metalloproteinases (MMPs) levels were determined by ELISA. Results Using a novel combination of these DNA and protein markers we identified with high confidence (99% negative predictive value) those patients who do not have cancer and who could be excluded from further testing. Cutoffs could be adjusted such that at 94% sensitivity, 65% of patients who do not have cancer could be excluded. Conclusions The Multi-Analyte Diagnostic Readout (MADR) assay described here combines the best performance characteristics of protein and DNA biomarkers into one assay for optimal clinical performance. Using this approach, the detection of FGFR3 mutations and Twist1 and Nid2 methylation in the urine of hematuria patients undergoing screening for bladder cancer effectively increases the sensitivity and negative predictive value at an established MMP protein cutoff. This non-invasive urinary diagnostic assay could lead to the more efficient triage of hematuria patients by identifying those patients who do not have cancer and could be excluded from receiving invasive procedures. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-313. doi:10.1158/1538-7445.AM2011-LB-313
Trapping and detection of ions generated in a high magnetic field electrospray ionization fourier transform ion cyclotron resonance mass spectrometer (1992)

The trapping and detection parameters employed with a Fourier transform ion cyclotron resonance (FTICR) mass spectrometer that is interfaced to a high magnetic field electrospray ionization (ES11 source are presented. ES1 occurs at atmospheric pressure in a 1.5-T field, and FTICR detection occurs 25 cm away at 3.0 T in either one of two cells separated by a conductance limit and maintained at pressure differentials of 5 × 10(5) and 2 × 10(7) torr, respectively. The continuous electrospray ion current traversing the high- and low-pressure cells is 350 and 100 pA, respectively. Retarding grid studies at the high-pressure cell indicate electrospray ion kinetic energies are controllable from less than an electronvolt to more than 10 eV. These kinetic energies are a function of desolvating capillary-skimmer assembly distance and the skimmer potential. Efficient accumulation of injected ions is accomplished only when the trap-plate potential matches the ion kinetic energy. If this condition is satisfied, the trapped ion cell fills to the ion space charge limit within a few hundred milliseconds. It is concluded that even at the high pressures used, the primary trapping mechanism cannot be solely collision dependent because the rate of ion accumulation is independent of background pressure. However, optimized FTICR excitation conditions for peptides and proteins in the mass range from 10(3) to more than 10(6) kDa are found to vary strongly with pressure; this is attributed to large mass- and charge-dependent differences in ion-molecule collision frequency.
Collusion-secure fingerprinting for digital data (1998)

This paper discusses methods for assigning code-words for the purpose of fingerprinting digital data, e.g., software, documents, music, and video. Fingerprinting consists of uniquely marking and registering each copy of the data. This marking allows a distributor to detect any unauthorized copy and trace it back to the user. This threat of detection will deter users from releasing unauthorized copies. A problem arises when users collude: for digital data, two different fingerprinted objects can be compared and the differences between them detected. Hence, a set of users can collude to detect the location of the fingerprint. They can then alter the fingerprint to mask their identities. We present a general fingerprinting solution which is secure in the context of collusion. In addition, we discuss methods for distributing fingerprinted data.
The Implementation of a 2-Core, Multi-Threaded Itanium Family Processor (2005)

The design of the high end server processor code named Montecito incorporated several ambitious goals requiring innovation. The most obvious being the incorporation of two legacy cores on-die and at the same time reducing power by 23%. This is an effective 325% increase in MIPS per watt which necessitated a holistic focus on power reduction and management. The next challenge in the implementation was to ensure robust and high frequency circuit operation in the 90-nm process generation which brings with it higher leakage and greater variability. Achieving this goal required new methodologies for design, a greatly improved and tunable clock system and a better understanding of our power grid behavior all of which required new circuits and capabilities. The final aspect of circuit design improvement involved the I/O design for our legacy multi-drop system bus. To properly feed the two high frequency cores with memory bandwidth we needed to ensure frequency headroom in the operation of the bus. This was achieved through several innovations in controllability and tuning of the I/O buffers which are discussed as well.