gebhart/patrepeval huggingface dataset:
Efficacy and safety of gefitinib and potential prognostic value of soluble EGFR, EGFR mutations, and tumor markers in a Gynecologic Oncology Group phase II trial of persistent or recurrent endometrial cancer (2009)

e16542 Background: A phase II trial was performed to evaluate the efficacy and safety of gefitinib and to explore epidermal growth factor receptor (EGFR, sEGFR), estrogen receptor (ER) and progesterone receptor (PRA, PRB) expression in persistent/recurrent endometrial cancer (EC). Methods: Women with histologically-confirmed, measurable, persistent/recurrent EC following one or two prior regimens were eligible and treated with 500 mg oral gefitinib daily until progression or severe toxicity. A 2-stage group sequential design was used to evaluate the regimen with PFS at 6 months as the primary endpoint. The trial had a 10% type I error rate with 90% power. sEGFR was quantified in serum and categorized at the median (1960 fmol/ml). Mutations in exons 18–21 of EGFR and IHC-expression of EGFR, pEGFR, ER, PRA, PRB, pERK, or Ki67 were examined in tumors. Results: Of the 29 enrolled, 26 were evaluable for efficacy and toxicity. Four had PFS ≥6 months, 1 had a complete response, 7 had stable disease, 16 had progressive disease and 2 were indeterminate. High pre-cycle 1 sEGFR level was favorably associated with OS (hazard ratio = 0.33, 95% confidence interval = 0.13–0.84). A mutation in exon 18 of EGFR (E709K) was observed but was not associated with clinical outcome. None of the tumor markers was associated with response, PFS, or OS. Among some of the notable correlations observed in primary tumor expression were ER with PRA (r = 0.504), EGFR with pERK (r = 0.802), and pEGFR with pERK (r = 0.728). Changes in expression were notable for pEGFR (increasing) and pERK (increasing) in primary versus pre-treatment persistent/recurrent tumor. Conclusions: The regimen was tolerable but lacked sufficient efficacy to warrant further evaluation in this setting, however, the association between serum sEGFR and OS, correlations between tumor markers, and changes in expression of pEGFR and pERK are interesting and should be validated in future investigations. This study was supported by NIH grant R01CA099908 and NCI grants CA27469, CA11479 and CA37517. No significant financial relationships to disclose.
Synthesis and X-ray crystal structure of the first homoleptic main group diazadiene complex, bis(1,4-di-t-butyl-1,4-diazabuta-1,3-diene) gallium (1989)

Cocondensation of gallium vapour with 1,4-di-t-butyl-1,4-diazabuta-1,3-diene (Butdab) affords the title compound as the first example of a homoleptic main group diazadiene complex; X-ray crystallography shows the molecule to possess distorted tetrahedral geometry, and together with e.s.r. and magnetic data suggests it to be a unique example of gallium(II) in which one of the diazadine ligands has been doubly reduced.
In Vitro and In Vivo Evaluation of BO-2727 against Imipenem- and/or Meropenem-resistant Pseudomonas aeruginosa. (1997)

The in vitro and in vivo activity of BO-2727, a carbapenem antibiotic, against resistant clinical isolates of Pseudomonas aeruginosa was studied. The geometric mean MICs against three groups of clinical isolates resistant to imipenem, meropenem and both carbapenems were 4.28, 4.08 and 5.44 micrograms/ml, respectively. BO-2727 also inhibited multiply antibiotic resistant isolates and laboratory mutants including a nalB-type mutant, which showed resistance to antibiotics such as imipenem, meropenem, ceftazidime, and/or ciprofloxacin, at less than 1.56 micrograms/ml. Overall, BO-2727 was 4-fold more active than biapenem, meropenem, panipenem and imipenem with an MIC90 of less than 6.25 micrograms/ml. The presence of basic amino acids in minimal medium less affected the antipseudomonal activity to a minimal extent, suggesting that BO-2727 has diverse penetration routes through the outer membrane other than OprD channel, which facilitates the diffusion of basic amino acids and carbapenems. The in vitro activity of BO-2727 reflected well in its therapeutic efficacy in experimental systemic infection in mice. These results suggest a possibility for the development of antipseudomonal carbapenems having activity against imipenem- and/or meropenem-resistant P. aeruginosa as well as a broad spectrum encompassing Gram-positive and -negative bacteria.
Development of Spintronic Bandgap Materials (2011)

The development of Ge/Si quantum dots with high spatial precision has been pursued, with the goal of developing a platform for “spintronics bandgap materials”. Quantum dots assemblies were grown by molecular beam epitaxy on carbon-templated silicon substrates. These structures were characterized by atomic force microscopy. Vertically gated structures were created on systems with up to six well-defined quantum dots with a controlled geometric arrangement, and low-temperature (mK) transport experiments were performed. These experiments showed evidence for a crossover from diamagnetic to Zeeman energy shifts in resonant tunneling of electrons through electronic states in the quantum dots.
Demonstrating ReCompFig: Designing Dynamically Reconfigurable Kinematic Devices Using Compliant Mechanisms and Tensioning Cables (2022)

From creating input devices to rendering tangible information, the field of HCI is interested in using kinematic mechanisms to create human-computer interfaces. Yet, due to fabrication and design challenges, it is often difficult to create kinematic devices that are compact and have multiple reconfigurable motional degrees of freedom (DOFs) depending on the interaction scenarios. In this work, we combine compliant mechanisms (CMs) with tensioning cables to create dynamically reconfigurable kinematic mechanisms. The devices’ kinematics (DOFs) is enabled and determined by the layout of bendable rods. The additional cables function as on-demand motion constraints that can dynamically lock or unlock the mechanism's DOFs as they are tightened or loosened. We provide algorithms and a design tool prototype to help users design such kinematic devices. We also demonstrate various HCI use cases including a kinematic haptic display, a haptic proxy, and a multimodal input device.
Effect of Vitamin C Supplements on Urinary Oxalate and pH in Calcium Stone-Forming Patients (2005)

No AccessJournal of UrologyUrological Survey: Urolithiasis, Endourology and Laparoscopy1 Feb 2005Effect of Vitamin C Supplements on Urinary Oxalate and pH in Calcium Stone-Forming Patients Ralph V. ClaymanM.D. Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)60510-1AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Effect of Vitamin C Supplements on Urinary Oxalate and pH in Calcium Stone-Forming Patients." The Journal of Urology, 173(2), pp. 478–479 © 2005FiguresReferencesRelatedDetails Volume 173Issue 2February 2005Page: 478-479 Advertisement Copyright & Permissions© 2005MetricsAuthor Information Ralph V. Clayman More articles by this author Expand All Advertisement Loading ...
An Advanced Liposomal Drug Delivery Vehicle: the Vesosome (2004)

Extended abstract of a paper presented at Microscopy and Microanalysis 2004 in Savannah, Georgia, USA, August 1–5, 2004.
Large Scale Eigenvalue Calculations for Computing the Stability of Buoyancy Driven Flows (2001)

No abstract prepared.
Arene transition-metal chemistry. 5. Arene ligand exchange and reactivity in .eta.6-arene iridium(I) complexes (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTArene transition-metal chemistry. 5. Arene ligand exchange and reactivity in .eta.6-arene iridium(I) complexesA. C. Sievert and E. L. MuettertiesCite this: Inorg. Chem. 1981, 20, 2, 489–501Publication Date (Print):February 1, 1981Publication History Published online1 May 2002Published inissue 1 February 1981https://pubs.acs.org/doi/10.1021/ic50216a034https://doi.org/10.1021/ic50216a034research-articleACS PublicationsRequest reuse permissionsArticle Views738Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Reliable Multi-GNSS Real-Time Kinematic Positioning (2018)

Surveying, agriculture and the navigation of autonomous robots, cars, ships and aerial systems require Global Navigation Satellite Systems (GNSS) for precise positioning. In this paper, we describe a Real-Time Kinematic (RTK) positioning method, that uses both GPS and Galileo measurements with a common reference satellite, estimates a pseudorange multipath error for each satellite to prevent a mapping of multipath errors into the position, and performs a hypothesis testing for ambiguity fixing. The proposed method is tested on the new Multi-Sensor, Multi-GNSS RTK positioning module of ANavS, which includes up to 3 GNSS receivers, an inertial sensor, a barometer and a processor for RTK positioning on a single board. The measurement results show a repeatable millimeter-level positioning accuracy.
Abstract 12592: Targeted Delivery of AntimiR-23a Using Ultrasound and Microbubbles Suppresses Cardiac Hypertrophy and Improves Cardiac Function in vivo (2016)

Background: MicroRNAs ( miRs ) are dysregulated in various cardiovascular diseases. An antimiR against miR-23a suppressed hypertension-induced cardiac hypertrophy in preclinical models, but clinical translation is limited by a lack of cardiac-targeted delivery systems. Ultrasound-targeted microbubble (MB) destruction (UTMD) is a novel therapeutic delivery platform that utilizes MBs as nucleic acid carriers and offers a non-invasive image-guided approach to target delivery of molecular therapeutics to the heart. We hypothesized that cardiac delivery of an antimiR against miR-23a using UTMD suppresses cardiac hypertrophy and improves cardiac function in hypertensive mice. Methods: Cationic lipid MBs were loaded with negative control antimiR ( NC ) or antimiR-23a. C57BL/6 mice were implanted with phenylephrine-loaded osmotic minipumps (100 mg/kg/d) and received UTMD treatments (1.3 MHz, MI setting=1.0) with 300 pmol antimiR 0, 3, and 7 days later. A third group (no phenylephrine, No-PE) of age matched mice received no treatments. At 2 weeks, miR-23a levels were measured using RT-PCR. Left ventricular (LV) mass and function were serially assessed with echocardiography. Results: UTMD treatment with antimiR-23a knocked down cardiac miR-23a by 41 ± 8% compared to UTMD treatment with NC (n=8-9/group, p&lt;0.01). As expected, phenylephrine increased LV mass relative to No-PE mice. However, compared to treatment with UTMD + NC, LV mass in mice with UTMD + antimiR-23a was 16 ± 2% lower after 1 week (p &lt; 0.05), and remained lower during the study (p=0.06) (Figure 1). By 2 weeks, fractional shortening had decreased in UTMD + NC but was preserved in UTMD + antimiR-23a (45.2% vs. 37.7%, p &lt; 0.05). Conclusions: To our knowledge, this is the first study to demonstrate suppression of cardiac hypertrophy and preservation of cardiac function with UTMD-targeted delivery of a miRNA inhibitor. Our data suggest that UTMD could be used to deliver other miRNA therapeutics for cardiac therapy.
Regulation of carbohydrate partitioning during the interaction of potato virus Y with tobacco (2000)

Abstract To test whether carbohydrates may play a signalling function during plant pathogenesis, we investigated the interaction between tobacco and potato virus Y (PVY N ). Four days after PVY N infection, leaves started to accumulate soluble sugars and leaf photosynthesis decreased. The accumulation of soluble sugars was accompanied by an induction of cell wall invertase and a gradual decrease in the sucrose‐to‐hexose ratio. In parallel to changes in carbohydrate metabolism and photosynthesis, transcripts encoding PR‐proteins accumulated. Based on this coincidence, it was hypothesized that elevated hexose levels may enhance the expression of defence‐related functions and might possibly explain the phenomenon of high sugar resistance in plants. This notion has been supported by the fact that cell wall invertase‐expressing transgenic tobacco plants were found to be resistant against PVY N ( ). To exclude the possibility that salicylate, which accumulates in plants expressing invertase, may be responsible for the observed resistance, these transgenic plants were crossed with salicylate hydroxylase‐expressing plants ( nahG ). The progeny were selected for high levels of sugar and low levels of salicylate. Necrotic lesions also developed, typically formed on the leaves of plants expressing invertase, and transcripts encoding PR‐Q accumulated in the absence of salicylate. On the other hand, accumulation of PR‐1b transcripts decreased, indicating that sugars are not sufficient for PR‐1b induction. Infection experiments using these plants as hosts revealed resistance towards PVY N . Thus, the mechanism of apoplastic invertase induced virus resistance is salicylate independent and most likely sugar mediated.
The Cues in "Dependent Multiple Cue Integration for Robust Tracking" Are Independent (2010)

A methodology for integrating multiple cues for tracking was proposed in several papers. These papers claim that, unlike other methodologies, conditional independence of the cues is not assumed. This brief communication 1) refutes this claim and 2) points out other major problems in the methodology.
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer (2020)

Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 × 10−8) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 BRCA1 mutation carriers genotyped on the iCOGS array. We identify four previously unidentified loci including two loci at 13q22 near KLF5, a 2p23.2 locus near WDR43 and a 2q33 locus near PPIL3 that display genome-wide significant associations with ER-negative breast cancer. In addition, 19 known breast cancer risk loci have genome-wide significant associations and 40 had moderate associations (P<0.05) with ER-negative disease. Using functional and eQTL studies we implicate TRMT61B and WDR43 at 2p23.2 and PPIL3 at 2q33 in ER-negative breast cancer aetiology. All ER-negative loci combined account for ∼11% of familial relative risk for ER-negative disease and may contribute to improved ER-negative and BRCA1 breast cancer risk prediction.
An ultra-low loss millimeter-wave solid state switch technology based on the metal - insulator - transition of vanadium dioxide (2014)

A new ultra-low-loss and broad band millimeter wave switch technology based on the reversible metal / insulator phase transition of vanadium dioxide has been developed. We report having fabricated series configured, single-pole single-throw (SPST) switches having measured S-parameters from DC to 110 GHz. The on-state insertion loss is 0.2 dB and off-state isolation is 21 dB at 50 GHz. The resulting impedance contrast ratio, Z <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">OFF</sub> /Z <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ON</sub> , is greater than 500:1 at 50GHz (i.e. cut-off frequency f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> ~ 40 THz). As a demonstration of the technology's utility, we also present the results of a 2-bit real time delay phase shifter incorporating a pair of VO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> SP4T switches. This switch technology's high impedance contrast ratio combined with its compactness, ease of integration, and low voltage operation make it an enabler of previously unachievable high-performance millimeter wave FPGAs.
Semisynthetic penicillins and cephalosporins containing the substituted 6-vinyl-1,2-dihydro-2-oxo- and 1,4-dihydro-4-oxo-3-pyridinecarboxylic acid side chains. Synthesis and structure-activity relationships. (1985)

A series of penicillins and cephalosporins containing the substituted 6-vinyl-1,2-dihydro-2-oxo- and 1,4-dihydro-4-oxo-3-pyridinecarboxylic acid side chains has been prepared and compared to piperacillin and cefoperazone. The compounds show good activity when tested in vitro against an array of Gram-negative bacteria. In vitro activity was also demonstrated against several species of Gram-positive bacteria. Two compounds, 14 and 21, show good in vivo activity when tested against Klebsiella pneumoniae, Enterobacter cloacae, and two strains of Pseudomonas aeruginosa.
IMPACT OF THE RECURRENCE OF HEPATITIS C VIRUS INFECTION AFTER LIVER TRANSPLANTATION ON THE LONG-TERM VIABILITY OF THE GRAFT1 (2002)

HCV infection recurrence leads to severe liver damage and subsequently to clinical decompensation in a significant proportion of OLT recipients. Some clinical and biochemical characteristics can predict the severity of HCV-induced graft damage.
Cultured slow vs. fast skeletal muscle cells differ in physiology and responsiveness to stimulation (2006)

In vitro studies have used protein markers to distinguish between myogenic cells isolated from fast and slow skeletal muscles. The protein markers provide some support for the hypothesis that satellite cells from fast and slow muscles are different, but the data are equivocal. To test this hypothesis directly, three-dimensional skeletal muscle constructs were engineered from myogenic cells isolated from fast tibialis anterior (TA) and slow soleus (SOL) muscles of rats and functionality was tested. Time to peak twitch tension (TPT) and half relaxation time (RT(1/2)) were approximately 30% slower in constructs from the SOL. The slower contraction and relaxation times for the SOL constructs resulted in left shift of the force-frequency curve compared with those from the TA. Western blot analysis showed a 60% greater quantity of fast myosin heavy chain in the TA constructs. 14 days of chronic low-frequency electrical stimulation resulted in a 15% slower TPT and a 14% slower RT(1/2), but no change in absolute force production in the TA constructs. In SOL constructs, slow electrical stimulation resulted in an 80% increase in absolute force production with no change in TPT or RT(1/2). The addition of cyclosporine A did not prevent the increase in force in SOL constructs after chronic low-frequency electrical stimulation, suggesting that calcineurin is not responsible for the increase in force. We conclude that myogenic cells associated with a slow muscle are imprinted to produce muscle that contracts and relaxes slowly and that calcineurin activity cannot explain the response to a slow pattern of electrical stimulation.
Identifying cysteine residues susceptible to oxidation by photoactivatable atomic oxygen precursors using a proteome-wide analysis (2021)

The reactivity profile of atomic oxygen [O(<sup>3</sup>P)] in the condensed phase has shown a preference for the thiol group of cysteines. In this work, water-soluble O(<sup>3</sup>P)-precursors were synthesized by adding aromatic burdens and water-soluble sulphonic acid groups to the core structure of dibenzothiophene-<i>S</i>-oxide (DBTO) to study O(<sup>3</sup>P) reactivity in cell lysates and live cells. The photodeoxygenation of these compounds was investigated using common intermediates, which revealed that an increase in aromatic burdens to the DBTO core structure decreases the total oxidation yield due to competitive photodeoxygenation mechanisms. These derivatives were then tested in cell lysates and live cells to profile changes in cysteine reactivity using the isoTOP-ABPP chemoproteomics platform. The results from this analysis indicated that O(<sup>3</sup>P) significantly affects cysteine reactivity in the cell. Additionally, O(<sup>3</sup>P) was found to oxidize cysteines within peptide sequences with leucine and serine conserved at the sites surrounding the oxidized cysteine. O(<sup>3</sup>P) was also found to least likely oxidize cysteines among membrane proteins.
Investigation of Surge Voltage Propagation in Inverter-Driven Electric Machine Windings (2022)

This article investigates what parameters affect the voltage propagation pattern in inverter-driven electric machine windings and presents mathematical analysis of this pattern with experiment verification. This work provides a thorough understanding of the behavior of machine windings under surge voltage excitations. First, high-fidelity finite element (FE) models were constructed with various combinations of factors in random-wound stranded machine windings. These factors include various types of parasitic capacitances, parasitic inductances of parallel strands, and different wire layouts in slots. The surge voltage distribution along the windings was simulated and compared among different cases to identify the key factors that affect this voltage propagation pattern. Subsequently, machine windings with both single-phase and three-phase structures were analyzed via equivalent circuits that were constructed with those key parameters. Then, the expressions of the coil voltage were derived in the Laplace domain. These expressions explicate the uneven surge voltage propagation pattern at various frequencies. Finally, for verification, both simulations and tests were conducted to analyze the surge voltage propagation in single-phase and three-phase windings.
Perspective on Pedestrian Inertial Navigation Systems (2021)

This chapter provides a perspective on further development of both the hardware and the software for pedestrian navigation. Hardware development for the pedestrian inertial navigation mainly aims to solve the problem of incorporating different sensing modalities with a reasonable size and weight, such that the overall system is compact, robust, and accurate. Software development for the pedestrian inertial navigation mainly aims to explore algorithms to fully use the collected data, in order to further improve the navigation accuracy and adaptivity without too much computational load. Cooperative localization can be achieved if multiple mobile agents are available in the network, with communication and computation capabilities, jointly processing a relative measurement between each agent to increase their localization accuracy. There are many ways to fully utilize the Inertial Measurement Unit data besides just integrating them into position estimation.