gebhart/patrepeval huggingface dataset:
Behavior of Serum Soluble lnterleukin-2 Receptor, Soluble CD8 and Soluble CD4 in the Early Phases of Acute Pancreatitis (1994)

When activated, lymphocytes secrete glycoproteins related to particular surface proteins, including soluble forms of the interleukin-2 receptor (sIL-2R) and of the surface proteins CD4 (sCD4) and CD8 (sCD8). We evaluated the release of these glycoproteins in order to assess the activation of the cellular immune system during the course of acute pancreatitis. Thirty-five patients with acute pancreatitis (22 M, 13 F, mean age 64 years, range 16-97) were studied. The diagnosis was based on typical abdominal pain associated with a twofold increase of serum lipase as well as morphological abnormalities compatible with acute pancreatitis seen at computed tomography and/or ultrasonography. The pancreatitis was of biliary origin in 22 patients, due to alcohol abuse in 8, due to pancreas divisum in 1, due to type IV hyperlipoproteinemia in 1 and of unknown origin in 3. Based on clinical outcome, 22 patients had mild pancreatitis, whereas 13 had severe disease. In all patients serum sIL-2R, sCD4 and sCD8 were determined on admission and daily for the following 5 days using enzyme immunoassay (EIA) techniques. Serum concentrations of sIL-2R and sCD8 were significantly higher in acute pancreatitis patients relative to healthy controls during the entire observation period, whereas sCD4 levels were significantly lower in acute pancreatitis patients than in the control group from the 2nd to the 6th day of observation. Serum sIL-2R concentrations were significantly higher in patients with severe pancreatitis than in those with the mild form of the disease, whereas no differences in serum concentrations of sCD8 and sCD4 were found between patients with mild pancreatitis and those with severe disease.(ABSTRACT TRUNCATED AT 250 WORDS)
Ceria‐Modified Copper Phyllosilicate Catalyst for One‐Pot Hydroamination of 5‐HMF with Nitro‐Compounds (2023)

Abstract Ceria‐modified mineral‐like copper catalyst 12 %Cu/SiO 2 −CeO 2 showed a high activity and selectivity in one‐pot hydroamination of bio‐available 5‐hydroxymethylfurfural with nitro‐aromatic compounds. The catalyst was obtained by conventional deposition‐precipitation method with urea from commercial silica, copper nitrate, and ammonium cerium (IV) nitrate. The synthesized catalyst with a copper phyllosilicate structure formed inside the pores of silica was studied by XRD, N 2 adsorption, XPS, SEM and TEM methods. The possible scheme of 5‐hydroxymethylfurfural hydroamination with nitro‐aromatic compounds and an evolution of the catalyst structure during the reaction were proposed. The catalyst can be successfully recycled after calcination procedure. A number of N ‐furfurylamines were obtained for the first time over 12 %Cu/SiO 2 −CeO 2 catalyst with the phyllosilicate structure directly from 5‐hydroxymethylfurfural and nitro‐aromatic compounds with the yields up to 85 %.
On A Partial Ordering Relation Derived from Redundancy of Slepian-Wolf Coding (2007)

Let (X, Y) denote a pair of finite-valued random variables. In this paper we use two examples to show an inherent partial ordering relation among the set {P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">y\x</sub> : H(X\Y) = a} where {Py\x : H(X\Y) = a} denotes the channel from X to Y, and 0 lesplusmn les H(X) is a constant. Specifically, we consider the following cases: the channel from X to Y is either a binary symmetric channel (BSC) or a binary erasure channel (BEC). In each case, we characterize the redundancy of Slepian-Wolf coding of X with decoder only side information Y. It is thus revealed that for any binary X and 0 < a < H(X), under the condition that H(X\Y) = a the redundancy of the BSC case is strictly larger than that of the BEC case for a range of decoding error probabilities. Interestingly, our results also reveal that the redundancy of variable-rate Slepian-Wolf coding is generally better than that of fixed-rate Slepian-Wolf coding.
Aspectos morfohistoquimicos de la inducción Epitelio-Mesenquimia en la organogénesis Dental. (1981)

Chronologic sequences of dental organogenesis rnorphohistochernical characteristica are described prior to appos:tional stage. They were the following: 1) Basal rnernbrane Fuchsin Aldehyde positive ( future arnelo-dentinal junc-tion). 2) Increase of cellu1ar layers-in intermediate stratum with metachromasia and alciar:ophilia in stellate reticulum. 3) Metachromasia and alcianophilia in papilla with differentiation of basophile odontoblasts on its periphery. 4) Alcianophile dentine deposit and PAS + with basophile ameloblasts polarity change and posterior secretion of adamantine matrix sligtly PAS +. Technical oxidai:ion variation with periodic acid during 10', Shiff reactive mbstance 15' and the posterior and inmmediate application of methenamine silver 1 hoUTat 609C allows to identify clearly ~reactive subst::mces to per;odic acid likeglucogene and basal memhrane reactive components
Prion Protein Expression in Human Leukocyte Differentiation (1998)

The cellular isoform of the prion protein (PrPC) is a small glycoprotein attached to the outer leaflet of the plasma membrane by a glycosylphosphatidylinositol anchor. This molecule is involved in the pathogenesis of prion diseases in both humans and animals. We have characterized the expression patterns of PrPC during human leukocyte maturation by flow cytometry with monoclonal antibodies to PrPC, the glycan moiety CD15, and the stem cell marker CD34. We observe that prion protein is present on CD34+ bone marrow (BM) stem cells. Although lymphocytes and monocytes maintain PrPC expression throughout their differentiation, PrPC is downregulated upon differentiation along the granulocyte lineage. In vitro retinoic acid-induced differentiation of the premyeloid line HL-60 into granulocyte-like cells mimics the suppression of PrPC in granulocyte differentiation, as both PrPC mRNA and protein are downregulated. These data suggest that selected BM cells and peripheral mononuclear cells may support prion agent replication, because this process is dependent on availability of PrPC. Additionally, retinoic acid-induced extinction of PrPC expression in HL-60 cells provides a potential model to study PrP gene regulation and protein function. Finally, these data suggest the existence of cell-specific glycoforms of PrPC that may determine cellular susceptibility to infection by the prion agent.
SU‐F‐E‐01: Pitfalls: Reliability and Performance of Diagnostic X‐Sources (2016)

Purpose: Performance and reliability of medical X‐ray tubes for imaging are crucial from an ethical, clinical and economic perspective. This lecture will deliver insight into the aspects to consider during the decision making process to invest in X‐ray imaging equipment. Outdated metric still hampers realistic product comparison. It is time to change this and to comply with latest standards, which consider current technology. Failure modes and ways to avoid down‐time of the equipment shall be discussed. In view of the increasing number of interventional procedures and the hazards associated with ionizing radiation, toxic contrast agents, and the combination thereof, the aspect of system reliability is of paramount importance. Methods: A comprehensive picture of trends for different modalities (CT, angiography, general radiology) has been drawn and led to the development of novel X‐ray tube technology. Results: Recent X‐ray tubes feature enhanced reliability and unprecedented performance. Relevant metrics for product comparison still have to be implemented in practice. Conclusion: The speed of scientific and industrial development of new diagnostic and therapeutic X‐ray sources remains tremendous. Still, users suffer from gaps between desire and reality in day‐to‐day diagnostic routine. X‐ray sources are still limiting cutting‐edge medical procedures. Side‐effects of wear and tear, limitations of the clinical work flow, costs, the characteristics of the X‐ray spectrum and others topics need to be further addressed. New applications and modalities, like detection‐based color‐resolved X‐ray and phase‐contrast / dark‐field imaging will impact the course of new developments of X‐ray sources. The author is employee of Royal Philips
The Third Order Nonlinearity-A Factor Limiting High SH Efficiency In Optical Fibres (1993)

Second harmonic generation (SHG) in optical glass fibres [1] is an unexpected but nevertheless potentially useful nonlinear phenomenon. Optical fibres offer several advantages in SHG over other devices. Firstly the combination of a long interaction length together with the high intensity possible in a small core permits the relatively small non-linear effects in glasses to be effectively utilised. Furthermore, the self-writing process of SHG in optical fibres may provide an automatic phase matching [2] which is vital in any efficient wave-mixing process. However since observation of efficient SHG in fibres by Österberg [3], there has been very little progress in increasing the efficiency of SHG in fibres, with the highest reported efficiency to date being 13% by Farries et al [4]. Whilst many theories have been proposed as to this efficiency limit, we present here, for the first time, an investigation of the effects of the third order nonlinearity on the second harmonic generation efficiency.
Validity of Vascular Prostaglandin Assay Methods (1992)

This study directly compares the three major methods of prostaglandin as say for explanted blood vessels in an effort to determine whether reliable assays can be performed on small, localized areas. Under general anesthesia, canine femoral arteries and veins (n =16) were excised after measurement of in vivo dimensions. Each vessel was divided into three segments. Vessel segments were (1) incubated as whole rings ("biopsy" method), (2) incubated with the luminal surface covered by a plexiglass well (well method), or (3) perfused with a pulsa tile pump at physiologic pressure, temperature, and flow rate for two fifteen minute cycles with a balanced salt solution (perfusion method). Perfusion seg ments were also tested by the well and biopsy methods after thirty minutes of ex vivo perfusion. Assays of stable metabolites for prostacyclin (Pc) and throm boxane A 2 (Tx) were performed using commercially available radioimmuno assay techniques. Luminal perfusion was used as the "gold standard" for corre lation. Mean values for Pc, Tx, and Pc/Tx ratio were compared for each method on both arteries and veins. In each case, the well method was statistically equiva lent to the perfusion method for the second fifteen-minute cycle, while the biop sy method was significantly different in several groups. Linear regression analysis revealed significant positive correlations between the well method and the per fusion method (r&gt;0.74, P&lt;0.01). The biopsy method did not correlate with the perfusion method in a significant manner (r 0.18 and 0.50, p&lt;0.05). Significant differences between the first and second perfusion cycle were seen in most cases. The wall method revealed trends toward decreased thromboxane production but no change in prostacyclin production for specimens after thirty minutes of perfusion. Conclusions: (1) The well incubation method demonstrates a significant positive corre lation with luminal perfusion while allowing assay of small localized areas. (2) Luminal perfusion is a reproducible technique, but larger vessel areas and more complex appara tus are required. Significant variations in luminal prostaglandin synthesis occur with se quential perfusion cycles, and the mechanism for the decrease in prostacyclin/thromboxane synthetase level or differing mechanisms for prostacyclin and thromboxane synthesis. (3) The vessel biopsy method is not reliable for comparisons with luminal perfusion or as a means of measuring luminal prostaglandin production.
Utilization of Sequential Palladium-Catalyzed Cross-Coupling Reactions in the Stereospecific Synthesis of Trisubstituted Olefins (2009)

A stereospecific synthesis of the drug-candidate 1 is described. The synthetic sequence, aimed at accomplishing modularity and cost savings, features a series of organometallic steps to afford stereospecifically the desired trisubstituded olefin active pharmaceutical ingredient. Key developments consist of a mild Sonogashira reaction of aryl bromide 7a with the polymerization prone propargyl alcohol and a stereospecific hydroalumination, Zn/Al exchange, and Pd-catalyzed cross-coupling sequence facilitated by the commercially available PEPPSI catalyst.
Broad-SpectrumIn VitroActivity andIn VivoEfficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the FamilyCoronaviridae (2009)

Viruses of the family Coronaviridae have recently emerged through zoonotic transmission to become serious human pathogens. The pathogenic agent responsible for severe acute respiratory syndrome (SARS), the SARS coronavirus (SARS-CoV), is a member of this large family of positive-strand RNA viruses that cause a spectrum of disease in humans, other mammals, and birds. Since the publicized outbreaks of SARS in China and Canada in 2002-2003, significant efforts successfully identified the causative agent, host cell receptor(s), and many of the pathogenic mechanisms underlying SARS. With this greater understanding of SARS-CoV biology, many researchers have sought to identify agents for the treatment of SARS. Here we report the utility of the potent antiviral protein griffithsin (GRFT) in the prevention of SARS-CoV infection both in vitro and in vivo. We also show that GRFT specifically binds to the SARS-CoV spike glycoprotein and inhibits viral entry. In addition, we report the activity of GRFT against a variety of additional coronaviruses that infect humans, other mammals, and birds. Finally, we show that GRFT treatment has a positive effect on morbidity and mortality in a lethal infection model using a mouse-adapted SARS-CoV and also specifically inhibits deleterious aspects of the host immunological response to SARS infection in mammals.
Construction of Urban Problem LOD using Crowdsourcing (2019)

Municipalities in Japan have various urban problems such as traffic accidents, illegally parked bicycles, and noise pollution.However, using these data to solve urban problems is difficult, as these data are not structurally constructed.Hence, we aim to construct the Linked Data set that will facilitate the solving of urban problems.In this paper, we propose a method for semi-automatic construction of Linked Data with the causality of urban problems, based on Web pages and open government data.Specifically, we extracted causal relations using natural language processing and crowdsourcing to include problem causality in the Linked Data.Then, we provided an example query to confirm the relationships be-tween several problems.Finally, we discussed our crowdsourcing task design for extracting urban problem causality.
Gallium phosphide transfer printing for integrated nonlinear photonics (2021)

Integrated nonlinear photonics has drawn an increased interest as it provides scalable, compact, and low cost solutions for a large range of applications. Indeed, the high confinement of the light in integrated waveguides allows for enhanced nonlinear effects. However, mature highly nonlinear platforms such as silicon-on-insulator (SOI) circuits suffer from nonlinear losses at telecom wavelengths caused by two-photon absorption. Moreover, the platform lacks a second order nonlinear susceptibility, which is not the case for wide bandgap III-V semiconductors. Recently, gallium phosphide-on-insulator (GaP-OI) has been proposed as an efficient platform for second and third order nonlinear applications [1] and last year we demonstrated as a proof of concept the transfer printing of GaP as a versatile technique for GaP hetero-integration [2] .
Morphologic study of the internalization of a lysosomal enzyme by the mannose 6-phosphate receptor in cultured Chinese hamster ovary cells. (1981)

The binding and internalization of a model lysosomal enzyme, beta-galactosidase, was visualized by use of rabbit anti-beta-galactosidase and goat anti-rabbit IgG; the second antibody was labeled with rhodamine or fluorescein (for detection by fluorescence) or with horseradish peroxidase (for electron microscopy). Chinese hamster ovary cells were incubated with beta-galactosidase at 4 degrees C, and then were washed and sequentially incubated in the cold with the two antibodies. The beta-galactosidase was found primarily in coated pits. The binding of the enzyme was completely inhibited by 5 mM mannose 6-phosphate. After the reaction with enzyme and antibodies, the cells were warmed to 37 degrees C; within 1 minute, the beta-galactosidase--antibody complex had begun to move to uncoated vesicles (receptosomes). After 8 min, the beta-galactosidase--antibody complex was seen in receptosomes near tubular elements in the Golgi/GERL area, within such tubular elements and at times, in vesicular elements that may correspond to coated structures of the GERL system. After 15 min, the enzyme--antibody complex was found in lysosomes near the Golgi/GERL are and a half-hour later it was in lysosomes distributed throughout the cytoplasm. Double-label experiments using beta-galactosidase and gold/alpha 2-macroglobulin showed the presence of the two ligands in the same coated pits and receptosomes. Thus, the pathway for internalization of beta-galactosidase via the mannose 6-phosphate receptor is similar to the pathway established for other ligands such as low density lipoprotein and alpha 2-macroglobulin.
Super-Resolution Spike Event-based Polarimetric Dynamic Vision Sensor p(DVS) Cognitive Imaging (2019)

In this study, a novel experimental design of a cognitive imaging system aiming at enhancing the spatial and temporal resolution of neuromorphic vision sensors, is presented. Super resolution images of moving or semi-obstructed targets, by means of the “Polarimetric Dynamic Vision Sensor (pDVS)” system, were obtained. This system improves the contrast sensitivity and proves to be an efficient strategy for rapid scene analysis by making use of deep learning. The outcome of this study has a tremendous impact to contribute to the design of innovative bioinspired-based vision systems for rapid classification, identification, motion detection, and tracking.
Filtration Behavior of Diesel Particulate Filters (2) (2007)

&lt;div class="htmlview paragraph"&gt;Due to its better fuel efficiency and low CO&lt;sub&gt;2&lt;/sub&gt; emissions, the number of diesel engine vehicles is increasing worldwide. Since they have high Particulate Matter (PM) emissions, tighter emission regulations will be enforced in Europe, the US, and Japan over the coming years. The Diesel Particulate Filter (DPF) has made it possible to meet the tighter regulations and Silicon Carbide and Cordierite DPF's have been applied to various vehicles from passenger cars to heavy-duty trucks. However, it has been reported that nano-size PM has a harmful effect on human health. Therefore, it is desirable that PM regulations should be tightened.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;This paper will describe the influence of the DPF material characteristics on PM filtration efficiency and emissions levels, in addition to pressure drop.&lt;/div&gt;
Hyperbranched porphyrins—a rapid synthetic approach to multiporphyrin macromolecules (2000)

A new class of porphyrin containing hyperbranched polymers has been prepared via proton-transfer polymerisation utilising an A2 + B3 approach, thus providing an accelerated entry into the construction of branched multiporphyrin architectures.
Prevention and Treatment of Cervical Cancer by Vaccination (2007)

Causality requires a judgment based on scientific evidence from human and experimental studies, as strict causality studies are often not appropriate in humans. Evidence linking certain human papillomavirus (HPV) genotypes to cervical carcinoma is extensive and compelling. More than two decades of research has led to the fulfillment of criteria, as proposed by Hill, to establish a causal link between high risk HPV infection and cervical cancer (Table 1). HPV DNA was first isolated from biopsies of cervical cancer more than 30 years ago (1, 2). HPV DNA is detected in 99.7% of cervical carcinomas worldwide. The evidence overwhelmingly demonstrates that persistent high risk HPV infection is a necessary but not sufficient cause of this cancer (3).
A detailed study of the diastereoselective catalytic hydrogenation of 6-hydroxytetrahydroisoquinoline-(3R)-carboxylic ester intermediates (2012)

A key step towards a highly-selective antagonist of ionotropic glutamate receptors entails the diastereoselective arene hydrogenation of an enantiopure tetrahydroisoquinoline. An extensive screen using parallel reactors was conducted and led to the discovery of several Pd/C catalysts giving high yield and improved diastereoselectivity from 75 : 25 to 95 : 5. A detailed kinetic study of the best system was performed and supports the reduction occuring in two-steps.
Direct and Indirect Observation of Lithium in a Scanning Electron Microscope; Not Only on Pure Li! (2015)

Journal Article Direct and Indirect Observation of Lithium in a Scanning Electron Microscope; Not Only on Pure Li! Get access P Hovington, P Hovington Hydro-Quebec Reaserch Institute, Varennes, Quebec, Canada Search for other works by this author on: Oxford Academic Google Scholar M Lagace, M Lagace Hydro-Quebec Reaserch Institute, Varennes, Quebec, Canada Search for other works by this author on: Oxford Academic Google Scholar E Principe, E Principe Tescan-Orsay Holding, USA Search for other works by this author on: Oxford Academic Google Scholar S Burgess, S Burgess Oxford Instruments NanoAnalysis, High Wycombe UK Search for other works by this author on: Oxford Academic Google Scholar A Guerfi, A Guerfi Hydro-Quebec Reaserch Institute, Varennes, Quebec, Canada Search for other works by this author on: Oxford Academic Google Scholar H Demers, H Demers Department of Mining and Materials Engineering, McGill University, Montreal, Quebec, Canada Search for other works by this author on: Oxford Academic Google Scholar R Gauvin, R Gauvin Department of Mining and Materials Engineering, McGill University, Montreal, Quebec, Canada Search for other works by this author on: Oxford Academic Google Scholar K Zaghib K Zaghib Hydro-Quebec Reaserch Institute, Varennes, Quebec, Canada Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 21, Issue S3, 1 August 2015, Pages 2357–2358, https://doi.org/10.1017/S1431927615012568 Published: 23 September 2015
The C-terminus of CIS defines its interaction pattern (2006)

Proteins of the SOCS (suppressors of cytokine signalling) family are characterized by a conserved modular structure with pre-SH2 (Src homology 2), SH2 and SOCS-box domains. Several members, including CIS (cytokine-inducible SH2 protein), SOCS1 and SOCS3, are induced rapidly upon cytokine receptor activation and function in a negative-feedback loop, attenuating signalling at the receptor level. We used a recently developed mammalian two-hybrid system [MAPPIT (mammalian protein-protein interaction trap)] to analyse SOCS protein-interaction patterns in intact cells, allowing direct comparison with biological function. We find that, besides the SH2 domain, the C-terminal part of the CIS SOCS-box is required for functional interaction with the cytokine receptor motifs examined, but not with the N-terminal death domain of the TLR (Toll-like receptor) adaptor MyD88. Mutagenesis revealed that one single tyrosine residue at position 253 is a critical binding determinant. In contrast, substrate binding by the highly related SOCS2 protein, and also by SOCS1 and SOCS3, does not require their SOCS-box.