gebhart/patrepeval huggingface dataset:
Decline of CD4 Lymphocyte Counts From the Time of Seroconversion in HIV-Positive Women (1992)

Human immunodeficiency virus (HIV) infection in women is increasing rapidly in North America and worldwide. The decline of CD4 lymphocyte counts from the time of seroconversion has been extensively studied in men, but not in women. We identified retrospectively forty HIV-positive women for whom the date of seroconversion could be determined to within a period of 9 months or less. A mean of 9.4 CD4 lymphocyte measurements per person were available over a mean follow-up period of 1.9 years with a variance of 1.5 years. By simple linear regression analysis, the mean decrease of the population of CD4 lymphocyte count per year was 70 cells/mm3. The mean time at which CD4 lymphocyte counts dropped below 500 was 5.1 years and the time at which CD4 counts dropped below 200 was 9.6 years after seroconversion. A local regression summary (lowess) yielded corresponding mean times of 4.0 years and 9.2 years, respectively. All women had access to continuing medical care, antiretro viral therapy, and had comprehensive social support services available to them. The current data are encouraging in that they indicate that the rate of decline of CD4 count from time of seroconversion in HIV-positive women is no greater than that which occurs in men, and indeed may be less rapid.
ChemInform Abstract: Structural and Synthetic Studies of the Spore Germination Autoinhibitor Gloeosporone. (1988)

Abstract The macrolide (IX) is prepared starting from the ester (I) via two asym.
Assignments of the 270 MHz PMR spectrum of somatostatin using pH titration, synthetic analogs and double resonance difference spectroscopy (1983)

We report the assignment procedure for the 270 MHz PMR spectrum in D 2 O of the 14 amino acid peptide hormone somatostatin, Ala 1 Gly 2 Cys 3 Lys 4 Asn 5 Phe 6 Phe 7 Trp 8 Lys 9 Thr 10 Phe 11 Thr 12 Ser 13 Cys 14 using a series of synthetic analogs in which a single amino acid residue was replaced by an Ala residue. The principal methods used were pH titration and extensive double resonance experiments (difference scalar decouplings and nuclear Overhauser effect measurements).
Machine learning predicts immunoglobulin light chain toxicity through somatic mutations (2019)

Abstract In systemic light chain amyloidosis (AL), pathogenic monoclonal immunoglobulin light chains (LCs) form toxic aggregates and amyloid fibrils in target organs. Prompt diagnosis is crucial to avoid permanent organ damage. However, delays in diagnosis are common, with a consequent poor patient’s prognosis, as symptoms usually appear only after strong organ involvement. Here, we present LICTOR, a machine learning approach predicting LC toxicity in AL, based on the distribution of somatic mutations acquired during clonal selection. LICTOR achieved a specificity and a sensitivity of 0.82 and 0.76, respectively, with an area under the receiver operating characteristic curve (AUC) of 0.87. Tested on an independent set of 12 LCs sequences with known clinical phenotypes, LICTOR achieved a prediction accuracy of 83%. Furthermore, we were able to abolish the toxic phenotype of an LC by in silico reverting two germline-specific somatic mutations identified by LICTOR and by experimentally assessing the loss of in vivo toxicity in a Caenorhabditis elegans model. Therefore, LICTOR represents a promising strategy for AL diagnosis and reducing high mortality rates in AL.
PEZO-1 and TRP-4 mechanosensors are involved in mating behavior in Caenorhabditis elegans (2022)

ABSTRACT Male mating in Caenorhabditis elegans is a complex behavior with a strong mechanosensory component. C. elegans has several characterized mechanotransducer proteins, but few have been shown to contribute to mating. Here, we investigated the roles of PEZO-1, a piezo channel, and TRP-4, a mechanotransducing TRPN channel, in male mating behavior. We show that pezo-1 is expressed in several male-specific neurons with known roles in mating. We show that, among other neurons, trp-4 is expressed in the PCA sensory neuron, which monitors relative sliding between the male and the hermaphrodite and inhibits neurons involved in vulva detection. Mutations in both genes compromise many steps of mating, including initial response to the hermaphrodite, scanning, turning, and vulva detection. We performed pan-neuronal imaging during mating between freely-moving mutant males and hermaphrodites. Both pezo-1 and trp-4 mutants showed spurious activation of the sensory neurons involved in vulva detection. In trp-4 mutants, this spurious activation might be caused by PCA failure to inhibit vulva-detecting neurons during scanning. Indeed, we show that without functional TRP-4, PCA fails to detect the relative sliding between the male and hermaphrodite. Cell-specific TRP-4 expression restores PCA’s mechanosensory function. Our results demonstrate new roles for both PEZO-1 and TRP-4 mechanotransducers in C. elegans mating behavior.
Motion of Grinding Media in Axial Direction and its Effect on Comminution in an Agitation Bead Mill [Translated]<sup>†</sup> (1996)

Grinding tests were carried out using a model agitation bead mill with a single disc. Four different types of disc were used to examine the effect of the motion of the grinding media in the axial direction. The median diameter of the ground product decreased with increasing axial movement of the grinding media under the same degree of fitting of the grinding media and rate of rotation. Contamination in the product from the agitating element and grinding vessel increased with increasing energy input, irrespective of the shape of the agitating disc. Contamination from the grinding media increased with an increase in the axial movement of the grinding media which promoted mutual collision and hence abrasion of the grinding media. KAGAKU KOGAKU RONBUNSHUVol. 21 (1995) No. 3 P 502-507† This report was originally printed in KAGAKU KOGAKU RONBUNSHU 21(3), 502-507 (1995) in Japanese, before being translated into English by KONA Editorial Committee with the permission of the editorial committee of the Soc. Chemical Engineers, Japan.
A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons (2018)

Activity-induced remodeling of neuronal circuits is critical for memory formation. This process relies in part on transcription, but neither the rate of activity nor baseline transcription is equal across neuronal cell types. In this study, we isolated mouse hippocampal populations with different activity levels and used single nucleus RNA-seq to compare their transcriptional responses to activation. One hour after novel environment exposure, sparsely active dentate granule (DG) neurons had a much stronger transcriptional response compared to more highly active CA1 pyramidal cells and vasoactive intestinal polypeptide (VIP) interneurons. Activity continued to impact transcription in DG neurons up to 5 h, with increased heterogeneity. By re-exposing the mice to the same environment, we identified a unique transcriptional signature that selects DG neurons for reactivation upon re-exposure to the same environment. These results link transcriptional heterogeneity to functional heterogeneity and identify a transcriptional correlate of memory encoding in individual DG neurons.
Electromechanical considerations in developing low-voltage RF MEMS switches (2003)

This paper reports on the design, fabrication, and testing of a low-actuation voltage Microelectromechanical systems (MEMS) switch for high-frequency applications. The mechanical design of low spring-constant folded-suspension beams is presented first, and switches using these beams are demonstrated with measured actuation voltages of as low as 6 V. Furthermore, common nonidealities such as residual in-plane and gradient stress, as well as down-state stiction problems are addressed, and possible solutions are discussed. Finally, both experimental and theoretical data for the dynamic behavior of these devices are presented. The results of this paper clearly underline the need of an integrated design approach for the development of ultra low-voltage RF MEMS switches.
Nitroso-Redox Balance and Modulation of Basal Myocardial Function: An Update from the Italian Society of Cardiovascular Research (SIRC) (2015)

Reactive oxygen species and reactive nitrogen species are produced endogenously by cardiomyocytes and are fundamental signaling molecules that regulate cellular function. Production of ROS and RNS is finely tuned to maintain proper myocardial function, but is altered in many pathophysiological conditions, therefore contributing to worsening myocardial dysfunction and ultimately heart failure. Indeed, an excess of ROS and RNS is central in many pathways leading to cardiac hypertrophy and failure, and the correct regulation of the nitroso-redox balance is fundamental for the function of the main components of the EC-coupling machinery. Broad antioxidant therapies have been proposed to improve myocardial function, but these therapies blunt even physiological ROS and RNS signaling, bringing limited, if any, beneficial effect. On the other hand, more targeted interventions on specific sources or pathways may produce promising results.
Short-Circuit Excitation Electrically Small Antenna Design With Reactive Loading (2022)

This paper presents an electrically small antenna design with short-circuit excitation and a lumped capacitor load. The antenna electrical size ka is 0.26 of maximum dimension $\lambda$/12, designed to match a differential 100 $\Omega$ reference impedance at 868 MHz. A geometrical parametric study is made to demonstrate the coupling change between the short-circuit excitation port and the lumped capacitor port. The simulated antenna performance shows complete matching to the reference impedance with 69% radiation efficiency including realistic lumped capacitor resistive losses.
Templating in shoulder arthroplasty – A comparison of 2D CT to 3D CT planning software: A systematic review (2019)

The paucity of evidence exploring clinical parameters makes it difficult to comment on clinical outcomes using different methods of templating. More studies are required to identify how improved radiographic outcomes translate into improvements that are clinically meaningful to patients.
Lowpass approximations of a constant amplitude with arbitrary phase and delay (1985)

Abstract A review is made of recent developments to the simultaneous lowpass approximation problem of amplitude, phase and delay. the closed from solutions (reciprocal and non‐reciprocal) are expressed in terms of the arbitrary phase and delay polynomials (APD).
Do Margins Matter? The Prognostic Significance of Positive Surgical Margins in Radical Prostatectomy Specimens (2008)

The prognostic significance of positive surgical margins (PSM) in radical prostatectomy (RP) specimens remains unclear. While most studies have concluded that a PSM is an independent adverse prognostic factor, others report that surgical margin status has no effect on prognosis. One reason for these discordant conclusions is the variable number of patients with a PSM who receive adjuvant therapy and the differing statistical methods used to account for the effects of the time course of adjuvant treatment on recurrence. We evaluated the prognostic significance of PSMs using multiple methods of analysis accounting for patients who received adjuvant therapy.We analyzed 1,389 consecutive patients with clinical stage T1-3 prostate cancer treated with RP by 2 surgeons from 1983 to 2000. Of 179 patients with a PSM, 37 received adjuvant therapy (AT), 29 radiation therapy and 8 received hormonal therapy. Because the method used to account for men receiving AT can affect the outcome of the analysis, data were analyzed by the Cox proportional hazards technique accounting for patients receiving AT using 5 methods: 1) exclusion, 2) inclusion (AT ignored), 3) censoring at time of AT, 4) failing at time of AT and 5) considering AT as a time dependent covariate.Overall 179 patients (12.9%) had a PSM, including 6.8% of 847 patients with pT2 and 23% of 522 patients with pT3 disease. A PSM was a significant predictor of cancer recurrence when analyzed using methods 1, 3, 4 and 5 (p=0.005, p=0.014, p=0.0005, p=0.002, respectively). However, it was not a predictor of recurrence using method 2 in which AT was ignored (p=0.283). Using method 5 multivariate analysis demonstrated that a PSM (p=0.002) was an independent predictor of 10-year progression-free probability (PFP) along with Gleason score (p=0.0005), extracapsular extension (p=0.0005), seminal vesicle invasion (p <0.0005), positive lymph nodes (p <0.0005) and preoperative serum prostate specific antigen (p <0.0001). Using method 5 the 10-year PFP was 58% +/- 12% and 81% +/- 3% for patients with and without a PSM, respectively (p <0.00005). The relative risk of recurrence in men with a PSM using method 5 was 1.52 (95% confidence interval 1.06-2.16).We confirm that a PSM has a significant adverse impact on PFP after RP in multivariate analysis using multiple statistical methods to account for patients who received AT. While prostate cancer screening strategies have resulted in a majority of men having organ confined disease at RP, surgeons should continue to strive to reduce the rate of positive surgical margins to improve cancer control outcomes.
Preparation of polymer-bound bipyridine and some of its transition metal complexes (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of polymer-bound bipyridine and some of its transition metal complexesRoger J. Card and Douglas C. NeckersCite this: J. Am. Chem. Soc. 1977, 99, 23, 7733–7734Publication Date (Print):November 1, 1977Publication History Published online1 May 2002Published inissue 1 November 1977https://doi.org/10.1021/ja00465a068RIGHTS & PERMISSIONSArticle Views159Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (296 KB) Get e-Alerts Get e-Alerts
Blood CD34-c-Kit+ cells rate correlates with aggressive forms of systemic mastocytosis and behave like a mast cell precursor. (2011)

International audience
Group Invariant Scattering (2012)

Abstract This paper constructs translation‐invariant operators on $\font\open=msbm10 at 10pt\def\R{\hbox{\open R}}{\bf L}^2({{{\R}}}^d)$ , which are Lipschitz‐continuous to the action of diffeomorphisms. A scattering propagator is a path‐ordered product of nonlinear and noncommuting operators, each of which computes the modulus of a wavelet transform. A local integration defines a windowed scattering transform, which is proved to be Lipschitz‐continuous to the action of C 2 diffeomorphisms. As the window size increases, it converges to a wavelet scattering transform that is translation invariant. Scattering coefficients also provide representations of stationary processes. Expected values depend upon high‐order moments and can discriminate processes having the same power spectrum. Scattering operators are extended on L 2 ( G ), where G is a compact Lie group, and are invariant under the action of G . Combining a scattering on $\font\open=msbm10 at 10pt\def\R{\hbox{\open R}}{\bf L}^2({{{\R}}}^d)$ and on L 2 ( SO ( d )) defines a translation‐ and rotation‐invariant scattering on $\font\open=msbm10 at 10pt\def\R{\hbox{\open R}}{\bf L}^2({{{\R}}}^d)$ . © 2012 Wiley Periodicals, Inc.
A Framework for Cross-Layer Evaluation of 5G mmWave Cellular Networks in ns-3 (2016)

The growing demand for ubiquitous mobile data services along with the scarcity of spectrum in the sub-6 GHz bands has given rise to the recent interest in developing wireless systems that can exploit the large amount of spectrum available in the millimeter wave (mmWave) frequency range. Due to its potential for multi-gigabit and ultra-low latency links, mmWave technology is expected to play a central role in 5th Generation (5G) cellular networks. Overcoming the poor radio propagation and sensitivity to blockages at higher frequencies presents major challenges, which is why much of the current research is focused at the physical layer. However, innovations will be required at all layers of the protocol stack to effectively utilize the large air link capacity and provide the end-to-end performance required by future networks. Discrete-event network simulation will be an invaluable tool for researchers to evaluate novel 5G protocols and systems from an end-to-end perspective. In this work, we present the first-of-its-kind, open-source framework for modeling mmWave cellular networks in the ns-3 simulator. Channel models are provided along with a configurable physical and MAC-layer implementation, which can be interfaced with the higher-layer protocols and core network model from the ns-3 LTE module to simulate end-to-end connectivity. The framework is demonstrated through several example simulations showing the performance of our custom mmWave stack.
GOAT'S MILK (1983)

Goats' milk is mainly sold in the frozen state and is often in short, unpredictable supply. It is usually twice the price of cows' milk and is packaged in either waxed‐lined cardboard or a thick polythene bag.
A Simple But Effective Bert Model for Dialog State Tracking on Resource-Limited Systems (2020)

In a task-oriented dialog system, the goal of dialog state tracking (DST) is to monitor the state of the conversation from the dialog history. Recently, many deep learning based methods have been proposed for the task. Despite their impressive performance, current neural architectures for DST are typically heavily-engineered and conceptually complex, making it difficult to implement, debug, and maintain them in a production setting. In this work, we propose a simple but effective DST model based on BERT. In addition to its simplicity, our approach also has a number of other advantages: (a) the number of parameters does not grow with the ontology size (b) the model can operate in situations where the domain ontology may change dynamically. Experimental results demonstrate that our BERT-based model outperforms previous methods by a large margin, achieving new state-of-the-art results on the standard WoZ 2.0 dataset <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> . Finally, to make the model small and fast enough for resource-restricted systems, we apply the knowledge distillation method to compress our model. The final compressed model achieves comparable results with the original model while being 8x smaller and 7x faster.
Goodyear Medalist Lecture: Rubber Research in the Service of Mankind (2008)

Abstract It all started at the EXXON Research and Engineering Co. during the 1960-ies where I became an apprentice/coworker of Robert M. Thomas (by the way, Thomas (Figure 1) was another Goodyear Medalist honored for the invention and early development of butyl rubber). 1
A Generalized Theorem of the Maximum (1990)

This paper generalizes the Theorem of the Maximum (Berge, 1963) to allow for discontinuous changes in the domain and the objective function. It also provides a geometrical version of the (generalized) theorem.
Topical diphenylcyclopropenone as a measure of immune competence in HIV-seropositive subjects. (2006)

We conclude that a single topical application of DPC at concentrations between 0.2% and 0.4% can serve as a measure of immune competence in HIV-seropositive patients. As a functional measure of immunocompetence, this DPC test provides information beyond a CD4 count, which is particularly relevant to HIV-positive subjects with CD4 counts between 200 and 350 cells/microL.
Metal vapor synthesis of a novel triple-decker sandwich complex: (.eta.6-mesitylene)2(.mu.-.eta.6:.eta.6-mesitylene)Cr2 (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetal vapor synthesis of a novel triple-decker sandwich complex: (.eta.6-mesitylene)2(.mu.-.eta.6:.eta.6-mesitylene)Cr2William M. LamannaCite this: J. Am. Chem. Soc. 1986, 108, 8, 2096–2097Publication Date (Print):April 1, 1986Publication History Published online1 May 2002Published inissue 1 April 1986https://pubs.acs.org/doi/10.1021/ja00268a063https://doi.org/10.1021/ja00268a063research-articleACS PublicationsRequest reuse permissionsArticle Views222Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Innentitelbild: Rationale Auswahl von Cyaninen zur Erzeugung von konjugierter Säure und freien Radikalen für die Photopolymerisation durch Belichtung bei 860 nm (Angew. Chem. 51/2021) (2021)

Cyanine mit Absorption zwischen 750–930 nm zeigen ein unterschiedliches Strukturmuster in Bezug auf die Endgruppen, Länge der Poylmethinkette und Substitution in der meso-Position. Diese bilden mit unterschiedlicher Effektivität initiierende Radikale und konjugierte Säure für die freie radikalische Polymerisation und die kationische Polymerisation von Vinylether in Kombination mit einem Diaryliodoniumsalz. Das Strukturmuster des Cyanins beeinflusst in bedeutender Form, ob Photochemie abläuft oder Wärme gebildet wird durch Kopplung von Schwingungen – ähnlich einem Musikstück, bei dem Schwingungen Sound in das System bringen, wie Bernd Strehmel et al. in ihrem Forschungsartikel auf S. 27059 darlegen.
Triply bridged polyoxapolyaza-heterophanes derived from 2,4,6-trichloro s-triazine. A new strategy in the synthesis of possible receptors of charged and/or neutral species (1983)

A new series of triply bridged polyoxapolyaza-triazinophanes, potentially capable of molecular recognition, has been synthesized by using the deffering reactivity of the three chlorine atoms of 2,4,6-trichloro-s-triazine towards nucleophiles.