gebhart/patrepeval huggingface dataset:
Pancreatic Neuroendocrine Neoplasm Associated with a Familial MAX Deletion (2020)

Most pancreatic neuroendocrine neoplasms (pNEN) occur sporadically but they can also occur as part of multiple endocrine neoplasia type 1 (MEN1). <i>MAX</i> was originally described as an inherited pheochromocytoma-paraganglioma risk gene, but also has recently been implicated in pituitary tumorigenesis. Here we describe the first case of a pNEN associated with an inherited <i>MAX</i> gene deletion in a family with endocrine tumors. The patient was a male carrier of an intragenic exon 3 deletion inherited from his father who had recurrent pheochromocytomas and a macroprolactinoma. The patient underwent screening and hormonal studies but no pheochromocytoma-paraganglioma, pituitary or renal tumors were identified. However, abdominal magnetic resonance imaging (MRI) identified a 1 cm lesion in body of the pancreas. The lesion was hyperintense on T2-weighted signal, and there was hyperfixation of the tumor on 68Ga-DOTANOC PET-CT images. No biochemical evidence of pancreatic hormone excess was identified. Following a guided biopsy, a pathological diagnosis of a low grade pNEN was made and immunohistochemistry showed loss of MAX nuclear staining. Genetic analysis of the tumor tissue indicated copy number neutral loss of heterozygosity consistent with uniparental disomy. This is the first reported case of a <i>MAX</i> deletion associated pNEN and strengthens the argument that <i>MAX</i> may represent an inheritable multiple endocrine neoplasia risk gene. Further analysis of germline and somatic <i>MAX</i> mutations/deletions in large cohorts of unexplained NEN cases could help clarify the potential role of MAX in NEN etiology.
Frequency Shifts of Micro and Nano Cantilever Beam Resonators Due to Added Masses (2016)

We present analytical and numerical techniques to accurately calculate the shifts in the natural frequencies of electrically actuated micro and nano (carbon nanotubes (CNTs)) cantilever beams implemented as resonant sensors for mass detection of biological entities, particularly Escherichia coli (E. coli) and prostate specific antigen (PSA) cells. The beams are modeled as Euler–Bernoulli beams, including the nonlinear electrostatic forces and the added biological cells, which are modeled as discrete point masses. The frequency shifts due to the added masses of the cells are calculated for the fundamental and higher-order modes of vibrations. Analytical expressions of the natural frequency shifts under a direct current (DC) voltage and an added mass have been developed using perturbation techniques and the Galerkin approximation. Numerical techniques are also used to calculate the frequency shifts and compared with the analytical technique. We found that a hybrid approach that relies on the analytical perturbation expression and the Galerkin procedure for calculating accurately the static behavior presents the most computationally efficient approach. We found that using higher-order modes of vibration of micro-electro-mechanical-system (MEMS) beams or miniaturizing the sizes of the beams to nanoscale leads to significant improved frequency shifts, and thus increased sensitivities.
P3522Vagus nerve stimulation for chronic heart failure: differences in therapy delivery and clinical efficacy in ANTHEM-HF, INOVATE-HF, and NECTAR-HF (2019)

Abstract Background Vagus Nerve Stimulation (VNS) is meant to deliver Autonomic Regulation Therapy (ART) to neurological targets with sufficient neuromodulation (NM) to ameliorate chronic heart failure (CHF). VNS delivery consists of its intensity (a combination of pulse amplitude, pulse frequency, and pulse duration), polarity, duty cycle (DC; stimulation “on” time and “off” time), and mode (continuous, or intermittent and periodic). In the ANTHEM-HF Pilot Study patients with CHF and reduced ejection fraction (HFrEF), VNS intensity was up-titrated until a change in heart rate (HR) dynamics was objectively confirmed. This did not require any change in GDMT and was associated with significant improvements in LVEF, 6-minute walk distance (6MWD), Minnesota Living with HF (MLWHF) score, and HR variability. Methods Qualitative and quantitative analyses used data from peer-reviewed publications and other sources in the public domain to compare VNS delivery in ANTHEM-HF, INOVATE-HF, and NECTAR-HF. Results (Table): Up-titration of VNS intensity was attempted in all 3 studies. In contrast to ANTHEM-HF, INOVATE-HF aimed only at peripheral neural targets. VNS intensity was delivered at a lower pulse frequency, and had a variable DC as a consequence of R-wave synchronization and only intermittent, periodic stimulation. In NECTAR-HF VNS intensity was delivered at a higher pulse frequency, and this was associated with intolerable adverse off-target effects which restricted VNS up-titration. Significant improvements in EF, 6MWD, MLWHF, and SDNN occurred in ANTHEM-HF relative to the other studies. ANTHEM-HF (n=60) INOVATE-HF (n=436) NECTAR-HF (n=63) Neural Target Central/Peripheral Peripheral Central/Peripheral Delivery Site Left or right CVN Right CVN Right CVN Delivery Intensity: Amplitude (milliamperes) 2.0±0.6 3.9±1.0 1.4±0.8 Frequency (Hertz) 10 1–2 20 Duration (microseconds) 250 500 300 Electrode Polarity (Cathode) Caudal Cephalad Caudal Duty Cycle 23% 25% 17% On Time/Off Time (seconds) 18/62 Variable 10/50 Mode of Delivery Cyclic/Continuous Intermittent/Periodic Cyclic/Continuous Clinical Efficacy at 6 Months: EF 32.4±7.2 to 37.2±10.4 Not available 30.5±6.0 to 32.7±6.4 6MWD 287±66 to 346±78 317±109 to 347±123 Not available MLWHFS 40±14 to 21±10 Not available 44.2±22.2 to 35.8±20.8 SDNN 94±26 to 111±50 Not available 146±48 to 130±52 Values reported as mean ± standard deviation; CVN = Cervical vagus nerve. *p&lt;0.05 versus NECTAR-HF; **p&lt;0.05 versus INOVATE-HF; ***p&lt;0.025 versus NECTAR-HF; ****p&lt;0.001 versus NECTAR-HF (Analysis using two-sample t-test of the means). Conclusion VNS differed in ANTHEM-HF when compared to INOVATE-HF and NECTAR-HF. The neural targets, pulse frequencies for titration, and the DC for NM were different. VNS in ANTHEM-HF was clinically efficacious. The ongoing ANTHEM-HFrEF Pivotal Study uses a similar paradigm. Acknowledgement/Funding LivaNova PLC
Downlink Received Power Performance Analysis of IRS for 6G Networks (2023)

The Internet of Things (IoT) is going to be a few of the most influential and critical role spectators in the post-5G and 6G wireless networking paradigm because IoT is being deployed in a variety of applications and services such as smart towns, smart homes, savvy environment monitoring, smart medical care, smart factories, savvy agri-business, and so on, with the goal of enabling intelligent coordination and efficiency improvement. An intelligent reflective surface (IRS) is a notable invention that will be included into 6G wireless systems to optimize the electromagnetic propagation atmosphere in a configurable or adjustable manner in order to increase communication between the transmitting and receiving devices. The study aims to increase IoT service coverage by employing IRS in micro wireless transmission. As a result, in terms of receiving power, the research investigated and compared the effectiveness of traditional small cellular connectivity with IRS-enhanced small cellular transmission in the 6G wireless IoT environment. According to the findings, deploying IRS greatly improves coverage for IoT-related services.
Structural Strength Evaluation of a Stainless Railroad Car (2012)

This study is an experimental research on using stainless steel car body structure for urban railway vehicles. The car body used in the experiment was made of stainless steel. To evaluate the structural characteristics and safety of the stainless car body, static load test was carried out by means of "Performance Test Standard for Electrical Multiple Unit" with the reference code JIS E 7105. The structural safety of the car body was evaluated by implementing vertical load, horizontal compressive load, twist load, and 3-point support tests. Test results verified that the structural safety of a car body was very stable and safe under design load conditions.
Miraculous Chemistry on the Han River (2017)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTMiraculous Chemistry on the Han RiverCarolyn BertozziView Author Information Department of Chemistry, Stanford UniversityE-mail: [email protected]Cite this: ACS Cent. Sci. 2017, 3, 5, 360–361Publication Date (Web):May 24, 2017Publication History Published online24 May 2017Published inissue 24 May 2017https://doi.org/10.1021/acscentsci.7b00204Copyright © 2017 American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoiceArticle Views1723Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (220 KB) Get e-AlertsSUBJECTS:Biomaterials,Metals,Nanoparticles,Students Get e-Alerts
Psychotherapy AI Companion with Reinforcement Learning Recommendations and Interpretable Policy Dynamics (2023)

We introduce a Reinforcement Learning Psychotherapy AI Companion that generates topic recommendations for therapists based on patient responses. The system uses Deep Reinforcement Learning (DRL) to generate multi-objective policies for four different psychiatric conditions: anxiety, depression, schizophrenia, and suicidal cases. We present our experimental results on the accuracy of recommended topics using three different scales of working alliance ratings: task, bond, and goal. We show that the system is able to capture the real data (historical topics discussed by the therapists) relatively well, and that the best performing models vary by disorder and rating scale. To gain interpretable insights into the learned policies, we visualize policy trajectories in a 2D principal component analysis space and transition matrices. These visualizations reveal distinct patterns in the policies trained with different reward signals and trained on different clinical diagnoses. Our system's success in generating DIsorder-Specific Multi-Objective Policies (DISMOP) and interpretable policy dynamics demonstrates the potential of DRL in providing personalized and efficient therapeutic recommendations.
Photoinduced Intramolecular Charge Transfer in Push−Pull Polyenes:  Effects of Solvation, Electron-Donor Group, and Polyenic Chain Length (2007)

Subpicosecond absorption spectroscopy is used to characterize the primary photoinduced processes in a class of push-pull polyenes bearing a julolidine end group as the electron donor and a diethylthiobarbituric acid end group as the electron acceptor. The excited-state decay time and relaxation pathway have been studied for four polyenes of increasing chain length (n = 2-5 double bonds) in aprotic solvents of different solvation time, polarity, and viscosity. Intramolecular charge transfer (ICT) leading to a transient state of cyanine-like structure (fully conjugated with no bond length alternation) is observed in all polar solvents at a solvent dependent rate, but the reaction is not observed in cyclohexane, a nonpolar solvent. In polar solvents, the reaction time increases with the average solvation time but remains slightly larger, except in the viscous solvent triacetin. These facts are interpreted as an indication that both solvent reorganization and internal restructuring are involved in the ICT-state formation. The observed photodynamics resemble those we previously found for another class of polyenes bearing a dibutylaniline group as the donor, including a similar charge-transfer rate in spite of the larger electron donor character of the julolidine group. This observation brings further support to the proposal that an intramolecular coordinate is involved in the charge-transfer reaction, possibly a torsional motion of the donor end group. On the other hand, relaxation of the ICT state leads to cis-trans isomerization or crossing to the triplet state, depending on the length of the polyenic chain. In dioxane, tetrahydrofuran, and triacetin, the ICT state of the shorter chains (n = 2, 3) relaxes to the isomer with a viscosity-dependent rate, while that of the longer ones (n = 4, 5) leads to the triplet state with a viscosity-independent rate, as expected. In acetonitrile, the ICT-state lifetime is generally much shorter. A change from photoisomerization to intersystem crossing at n = 4 is also proposed in this solvent, but the formation of a photoproduct at n = 2 is not clear. In cyclohexane, where the ICT state is not formed, the relaxation pathway of the initially excited state is found to lead to an isomer for n = 2. As in polar solvents, a change to intersystem crossing at n = 4 is proposed. The direct relaxation to the ground state found at n = 3 for the series bearing a dibutylaniline group is not observed with the julolidine group. The results clearly illustrate that photoinduced reaction trajectories in push-pull polyenes are controlled by the static and dynamic properties of the solvent, the chemical nature and size of the end groups, and the conjugated-chain length and flexibility.
Effects of low- and high-advanced glycation endproduct meals on macro- and microvascular endothelial function and oxidative stress in patients with type 2 diabetes mellitus [Erratum: 2007 Oct., v. 86, no, 4, p. 1256.] (2007)

BACKGROUND: An advanced glycation endproducts (AGEs)-rich diet induces significant increases in inflammatory and endothelial dysfunction markers in type 2 diabetes mellitus (T2DM). OBJECTIVE: The aim was to investigate the acute effects of dietary AGEs on vascular function in T2DM patients. DESIGN: Twenty inpatients with T2DM [[Formula: see text] (±SEM) age: 55.4 ± 2.2 y; glycated hemoglobin: 8.8 ± 0.5%] were investigated. In a randomized crossover design, the effects of a low-AGE (LAGE) and high-AGE (HAGE) meal on macrovascular [by flow-mediated dilatation (FMD)] and microvascular (by Laser-Doppler flowmetry) function, serum markers of endothelial dysfunction (E-selectin, intracellular adhesion molecule 1, and vascular cell adhesion molecule 1), oxidative stress, and serum AGE were assessed. The meals had identical ingredients but different AGE amounts (15.100 compared with 2.750 kU AGE for the HAGE and LAGE meals, respectively), which were obtained by varying the cooking temperature and time. The measurements were performed at baseline and 2, 4, and 6 h after each meal. RESULTS: After the HAGE meal, FMD decreased by 36.2%, from 5.77 ± 0.65% (baseline) to 3.93 ± 0.48 (2 h), 3.70 ± 0.42 (4 h), and 4.42 ± 0.54% (6 h) (P < 0.01 for all compared with baseline). After the LAGE meal, FMD decreased by 20.9%, from 6.04 ± 0.68% (baseline) to 4.75 ± 0.48% (2 h), 4.69 ± 0.51% (4 h), and 5.62 ± 0.63% (6 h), respectively (P < 0.01 for all compared with baseline; P < 0.001 for all compared with the HAGE meal). This impairment of macrovascular function after the HAGE meal was paralleled by an impairment of microvascular function (-67.2%) and increased concentrations of serum AGE and markers of endothelial dysfunction and oxidative stress. CONCLUSIONS: In patients with T2DM, a HAGE meal induces a more pronounced acute impairment of vascular function than does an otherwise identical LAGE meal. Therefore, chemical modifications of food by means of cooking play a major role in influencing the extent of postprandial vascular dysfunction.
Highly Regio- and Enantioselective Hydroformylation of Vinyl Esters Using Bidentate Phosphine,P-Chiral Phosphorodiamidite Ligands (2016)

Hybrid bidentate phosphine-phosphorodiamidite ligands based on a chiral Betti base backbone and diphenylphosphinoaniline derivatives have been prepared (BettiPhos). The ligands possess a stereogenic P atom at the phosphorodiamidite moiety, whose configuration can be largely controlled by the synthetic route and the choice of base and solvent. The new ligands were applied in the rhodium-catalyzed asymmetric hydroformylation (AHF) of vinyl esters and vinyl amides. Very high enantioselectivities of up to 97% ee accompanied by excellent regioselectivities (up to b/l > 1000) were obtained using the BettiPhos ligand (SC,SC,RP,SC)-4b bearing an additional chiral group at the aniline nitrogen. The catalyst resting state [RhH(CO)2{(SC,SC,RP,SC)-4b}] was investigated by high pressure-NMR studies, revealing an equatorial–apical coordination of the bidentate ligand where the two phosphorus donors rapidly exchange their positions through an intermediate with the ligand bound via the phosphine group only.
Measuring flow velocity of swallowed liquid in the human pharynx by tongue pressure sensor and swallowing sound sensor (2014)

We measured flow velocity of swallowed liquid passing through pharynx. We put a pressure sensor on a palate to measure tongue pressure when swallowing the liquid. And we put two acoustic sensors on the neck skin in order to measure swallowing sound when liquid passes through the pharynx. From the output of these three sensors, we can know the timing of the liquid passing through each sensor points and can calculate the flow velocity of the swallowed liquid at the pharynx. In this paper, we compare the flow velocity between two swallowing positions, “look forward position” and “look upward position.” As a result, we found that the flow velocity of the “look upward position” was 2.5 times faster than that of “look forward position.”.
Indium-tin-oxide clad blue and true green semipolar InGaN/GaN laser diodes (2013)

Replacing a portion of the upper III-nitride cladding with indium-tin-oxide (ITO) has several potential advantages for GaN-based laser diodes (LDs). For green LDs, use of ITO in the waveguide structure reduces the epitaxial p-cladding thickness and growth time, which in turn may reduce thermal damage to the active region. We design ITO-clad blue and green semipolar (202¯1) LDs using asymmetric InGaN waveguiding layers to center the mode on the active region. Lasing is demonstrated at 471 nm with threshold current density of 6.2 kA/cm2 for a device with 200 nm p-GaN and at 518 nm for a device with only 300 nm of p-GaN.
Correction: Impaired Antibody Response Causes Persistence of Prototypic T Cell–Contained Virus (2009)

CD8 T cells are recognized key players in control of persistent virus infections, but increasing evidence suggests that assistance from other immune mediators is also needed. Here, we investigated whether specific antibody responses contribute to control of lymphocytic choriomeningitis virus (LCMV), a prototypic mouse model of systemic persistent infection. Mice expressing transgenic B cell receptors of LCMV-unrelated specificity, and mice unable to produce soluble immunoglobulin M (IgM) exhibited protracted viremia or failed to resolve LCMV. Virus control depended on immunoglobulin class switch, but neither on complement cascades nor on Fc receptor c chain or Fc c receptor IIB. Cessation of viremia concurred with the emergence of viral envelope-specific antibodies, rather than with neutralizing serum activity, and even early nonneutralizing IgM impeded viral persistence. This important role for virus-specific antibodies may be similarly underappreciated in other primarily T cell-controlled infections such as HIV and hepatitis C virus, and we suggest this contribution of antibodies be given consideration in future strategies for vaccination and immunotherapy.
Multi-scale mapping along the auditory hierarchy using high-resolution functional UltraSound in the awake ferret (2018)

A major challenge in neuroscience is to longitudinally monitor whole brain activity across multiple spatial scales in the same animal. Functional UltraSound (fUS) is an emerging technology that offers images of cerebral blood volume over large brain portions. Here we show for the first time its capability to resolve the functional organization of sensory systems at multiple scales in awake animals, both <i>within</i> small structures by precisely mapping and differentiating sensory responses, and <i>between</i> structures by elucidating the connectivity scheme of top-down projections. We demonstrate that fUS provides stable (over days), yet rapid, highly-resolved 3D tonotopic maps in the auditory pathway of awake ferrets, thus revealing its unprecedented functional resolution (100/300µm). This was performed in four different brain regions, including very small (1-2 mm<sup>3</sup> size), deeply situated subcortical (8 mm deep) and previously undescribed structures in the ferret. Furthermore, we used fUS to map long-distance projections from frontal cortex, a key source of sensory response modulation, to auditory cortex.
Effect of forphenicinol, a low molecular weight immunomodifier, on the growth of and the immune responses to murine lymphoma EL4. (1987)

Oral administration of forphenicinol, S-2-(3-hydroxy-4-hydroxymethylphenyl)glycine, inhibited the growth of EL4 lymphoma by both pre- and posttreatment. Although some mice given this drug rejected the tumor, they could not obtain acquired immunity against the tumor. Macrophages taken from normal mice did not inhibit the growth of EL4 cells in vivo (tumor neutralization assay) or in vitro (cytostasis assay). Forphenicinol induced effector activity in such macrophages neither in vitro nor in vivo. Forphenicinol administration to mice bearing EL4 activated macrophages to inhibit the growth of EL4 in vitro and in vivo. Moreover, it stimulated the tumor growth-inhibitory activity of splenocytes in both tumor-free and tumor-bearing mice.
Design, fabrication, and characterization of large metalenses (2023)

This work demonstrates the utility of a design, fabrication, and testing loop on 10 mm diameter metalenses to accelerate large-scale production of flat optics. By enabling rapid measurement and analysis of metalenses, it is possible to identify differences between designed performance and as-built performance quickly and correlate those to process characteristics. This accelerated feedback between the design, fabrication, and testing is expected to enable higher yields of better-performing metalenses.
Computer-aided design of a magnetron sputtering cathode (1986)

A finite element computer program is used to aid the design of a magnetron sputtering cathode. The calculated magnetic fields are shown to accurately predict the wear of the sputtering target. New designs are also evaluated using the finite element program.