gebhart/patrepeval huggingface dataset:
KPT-SINE, a Potent, Small Molecule Inhibitor of CRM1-Dependent Nuclear-Cytoplasmic Shuttling, with Potent Activity Against T-ALL and AML (2011)

Abstract Abstract 2622 Background: CRM1 (XPO1) is the major nuclear exporter that mediates transport of a variety of cargos, including proteins involved in tumor suppressor and cellular proliferation pathways (e.g. p53, PI3K/AKT, and NF-kB). CRM1 is upregulated in a range of solid and hematologic malignancies and its overexpression is correlated with poor prognosis, and with resistance to chemotherapy. Recently, the crystal structure of CRM1, in complex with its export cargo, Snurportin 1, has been resolved. The structure elucidates the key contact residues required for the formation of the CRM1-cargo export complex. The molecular understanding of the CRM1-cargo binding interface has led to the development of novel small molecule inhibitors of CRM1-cargo interaction, termed KPT-Selective Inhibitors of Nuclear Export (SINE). KPT-SINE are potent, drug-like CRM1 inhibitors that irreversibly inactivate the CRM1-directed protein export by covalent modification of the essential CRM1-cargo binding residue Cys528. The inhibition of the CRM1 nuclear export has been shown to lead to selective apoptosis in cancer cells when compared to normal cells. Here, we assess the efficacy of the KPT-SINE in human T-ALL, AML, and normal hematopoietic cells. Methods: The viability of a panel of human T-ALL and AML cell lines and normal CD34+ progenitor cells upon treatment by the KPT-SINE was assessed. Dose-response measurements were done using serial dilutions of KPT-SINE from 1 μM to 0.3 nM and luminescent cell viability assay. Apoptosis was measured using Annexin V staining and TUNEL assays. Results: KPT-SINE induces rapid apoptosis in 12 of 15 T-ALL and 10 of 14 AML cell lines with 50% inhibitory concentrations (IC50s) of 15–100 nM. In the KPT-SINE-sensitive cell lines, BCL2 overexpression suppresses KPT-SINE-induced apoptosis, indicating its intrinsic pathway mediation. Importantly, KPT-SINE exhibits selective cytotoxicity against tumor cells when compared to peripheral blood mononuclear cells (PBMCs) and CD34+ progenitor cells in vitro. KPT-SINE at 57 and 150 mg/kg induced 100% inhibition of tumor growth in vivo in a MOLT-4 T-ALL xenograft study. Other xenograft studies to address the potency of the KPT-SINE on selected AML lines in vivo are ongoing. These studies emphasize the clinical promise of the KPT-SINE as a novel and selective drug candidate for the treatment of T-ALL and AML. Disclosures: McCauley: Karyopharm Therapeutics: Employment. Kauffman:Karyopharm: Equity Ownership. Shacham:Karyopharm: Equity Ownership.
Oxo 2-Adamantylidene Complexes of Mo(VI) and W(VI) (2021)

Molybdenum and tungsten oxo 2-adamantylidene (Adene) complexes that contain two nonafluoro-tert-butoxide (ORF9) ligands have been prepared through addition of 2-methylene- or 2-ethylideneadamantane to neophylidene or neopentylidene complexes. The isolated oxo complexes include W(O)(Adene)(ORF9)2(PPh2Me) (1W), W(O)(Adene)(ORF9)2 (2W), W(O)(Adene)(2,5-dimethylpyrrolide)2 (3W), W(O)(Adene)(2,5-dimethylpyrrolide)(2,6-dimesitylphenoxide) (4W), Mo(O)(Adene)(ORF9)2(PPhMe2) (1Mo), and Mo(O)(Adene)(ORF9)2 (2Mo). Compound 2W is a dimer that contains unsymmetrically bridging oxo ligands; it dissociates readily and reversibly into monomers, especially in the presence of a donor such as THF. In contrast, 2Mo is a monomer. Both 2W and 2Mo are remarkably stable thermally. The pale-blue complexes Mo(Adene)(ORF9)2Cl2 (5Mo) and W(Adene)(ORF9)2Cl2 (5W) are formed upon addition of PCl5 to 2Mo and 2W, respectively. The oxo complexes are reactive olefin metathesis initiators, while 5Mo and 5W are relatively poor initiators. We ascribe the thermal stability of 2Mo and 2W to resistance of the 2-adamantylidene ligands to couple bimolecularly, to the absence of an α-hydrogen in the alkylidene, or both.
CO2 Electroreduction in Water with a Heterogenized C-Substituted Nickel Cyclam Catalyst (2022)

Molecular catalysis for selective CO<sub>2</sub> electroreduction into CO can be achieved with a variety of metal complexes. Their immobilization on cathodes is required for their practical implementation in electrolytic cells and can benefit from the advantages of a solid material such as easy separation of products and catalysts, efficient electron transfer to the catalyst, and high stability. However, this approach remains insufficiently explored up to now. Here, using an appropriate and original modification of the cyclam ligand, we report a novel [Ni(cyclam)]<sup>2+</sup> complex which can be immobilized on carbon nanotubes. This material, once deposited on a gas diffusion layer, provides a novel electrode which is remarkably selective for CO<sub>2</sub> electroreduction to CO, not only in organic solvents but also, more remarkably, in water, with faradic efficiencies for CO larger than 90% and current densities of 5-10 mA cm<sup>-2</sup> during controlled potential electrolysis in H-cells.
A Serological Snapshot of COVID-19 Initial Stages in Israel by a 6-Plex Antigen Array (2021)

The first case of SARS-CoV-2 was discovered in Israel in late February 2020. Three major outbreaks followed, resulting in over 800,000 cases and over 6,000 deaths by April 2021. Our aim was characterization of a serological snapshot of Israeli patients and healthy adults in the early months of the COVID-19 pandemic. Sera from 55 symptomatic COVID-19 patients and 146 healthy subjects (early-pandemic, reverse transcription-quantitative PCR [qRT-PCR]-negative), collected in Israel between March and April 2020, were screened for SARS-CoV-2-specific IgG, IgM, and IgA antibodies, using a 6-plex antigen microarray presenting the whole inactivated virus and five viral antigens: a stabilized version of the spike ectodomain (S2P), spike subunit 1 (S1), receptor-binding-domain (RBD), N-terminal-domain (NTD), and nucleocapsid (NC). COVID-19 patients, 4 to 40 days post symptom onset, presented specific IgG to all of the viral antigens (6/6) in 54 of the 55 samples (98% sensitivity). Specific IgM and IgA antibodies for all six antigens were detected in only 10% (5/55) and 4% (2/55) of the patients, respectively, suggesting that specific IgG is a superior serological marker for COVID-19. None of the qRT-PCR-negative sera reacted with all six viral antigens (100% specificity), and 48% (70/146) were negative throughout the panel. Our findings confirm a low seroprevalence of anti-SARS-CoV-2 antibodies in the Israeli adult population prior to the COVID-19 outbreak. We further suggest that the presence of low-level cross-reacting antibodies in naive individuals calls for a combined, multiantigen analysis for accurate discrimination between naive and exposed individuals. <b>IMPORTANCE</b> A 6-plex protein array presenting the whole inactivated virus and five nucleocapsid and spike-derived SARS-CoV-2 antigens was used to generate a serological snapshot of SARS-CoV-2 seroprevalence and seroconversion in Israel in the early months of the pandemic. Our findings confirm a very low seroprevalence of anti-SARS-CoV-2 antibodies in the Israeli adult population. We further propose that the presence of low-level nonspecific antibodies in naive individuals calls for a combined, multiantigen analysis for accurate discrimination between naive and exposed individuals enabling accurate determination of seroconversion. The developed assay is currently applied to evaluate immune responses to the Israeli vaccine during human phase I/II trials.
Ab initio theory of quantum fluctuations and relaxation oscillations in multimode lasers (2019)

We present an ab initio semi-analytical solution for the noise spectrum of complex-cavity microstructured lasers, including central Lorentzian peaks at the multimode lasing frequencies and additional sidepeaks due to relaxation-oscillation (RO) dynamics. In Phys. Rev. A91, 063806 (2015)PLRAAN1050-294710.1103/PhysRevA.91.063806, we computed the central-peak linewidths by solving generalized laser rate equations, which we derived from the Maxwell&#x2013;Bloch equations by invoking the fluctuation&#x2013;dissipation theorem to relate the noise correlations to the steady-state lasing properties. Here, we generalize this approach and obtain the entire laser spectrum, focusing on the RO sidepeaks. Our formulation treats inhomogeneity, cavity openness, nonlinearity, and multimode effects accurately. We find a number of new effects, including new multimode RO sidepeaks and three generalized &#x03B1; factors. Last, we apply our formulas to compute the noise spectrum of single-mode and multimode photonic-crystal lasers.
Towards a Fundamental Understanding of the Oxygen Reduction Mechanism (2011)

The kinetics of oxygen reduction are thermally activated, therefore as solid oxide fuel cell (SOFC) operating temperature is lowered, the rates of chemical reactions drop exponentially, and activation polarization at the cathode dominates SOFC performance. Hence, cathode polarization is widely regarded to be the key issue hindering reduced temperature SOFC development. In order to understand the various mechanistic contributions to cathode polarization and apply this knowledge to development of lower-polarization/lower-temperature SOFC cathodes, we have embarked on a multi-faceted, multi-disciplinary approach to deconvolute the various contributions to SOFC cathode polarization. This approach includes FIB/SEM to quantify the cathode microstructure and heterogeneous catalysis techniques and O-isotope exchange to evaluate the O2 reduction mechanism at the gas-solid reaction interface. These results are then combined (and contrasted) with more conventional electrochemical polarization techniques to try and elucidate each of the mechanisms as a function of composition and microstructure. The progress to date is summarized.
Direct numerical simulation of the turbulent boundary layer over a rod-roughened wall (2007)

The effects of surface roughness on a spatially developing turbulent boundary layer (TBL) are investigated by performing direct numerical simulations of TBLs over rough and smooth walls. The Reynolds number based on the momentum thickness was varied in the range Re θ = 300 ∼ 1400. The roughness elements were periodically arranged two-dimensional spanwise rods, and the roughness height was k = 1.5θ in , where θ in is the momentum thickness at the inlet, which corresponds to k /δ = 0.045 ∼ 0.125, δ being the boundary layer thickness. To avoid generating a rough-wall inflow, which is prohibitively difficult, a step change from smooth to rough was placed 80θ in downstream from the inlet. The spatially developing characteristics of the rough-wall TBL were examined. Along the streamwise direction, the friction velocity approached a constant value, and self-preserving forms of the turbulent Reynolds stress tensors were obtained. Introduction of the roughness elements affected the turbulent stress not only in the roughness sublayer but also in the outer layer. Despite the roughness-induced increase of the turbulent Reynolds stress tensors in the outer layer, the roughness had only a relatively small effect on the anisotropic Reynolds stress tensor in the outer layer. Inspection of the triple products of the velocity fluctuations revealed that introducing the roughness elements onto the smooth wall had a marked effect on vertical turbulent transport across the whole TBL. By contrast, good surface similarity in the outer layer was obtained for the third-order moments of the velocity fluctuations.
Post-operative epiphora following the transcutaneous medial canthal incision (2019)

Abstract Purpose The safety profile of the transcutaneous medial canthal incision for access to the medial orbit is assessed with a focus on the risk of post-operative iatrogenic epiphora. Methods A retrospective chart review of patients undergoing medial orbitotomy via the transcutaneous medial canthal incision was performed. Patients with a minimum of 3 months of follow-up were included and post-operative complications were assessed and characterized. Results One-hundred-fifty patients were included in the study. A total of 4 complications were identified, including one each of the following: nasolacrimal duct obstruction, hypertrophic scar, suture granuloma and soft tissue infection. Only the nasolacrimal duct obstruction required surgical intervention. Discussion Access to the medial orbit has been achieved through a variety of approaches, each with their own benefits and risk profile. The transcaruncular approach has increased in usage as a means to avoid a visible cutaneous scar and decrease the risk of iatrogenic epiphora, however, there are specific patients who may have relative contraindications to this approach. The current study demonstrates the low risk profile of the transcutaneous medial canthal incision, specifically the minimal risk of iatrogenic damage to the nasolacrimal outflow system. This approach is another useful tool which orbit surgeons should be familiar with to offer as an option to patients requiring medial orbitotomy.
Effects of Human Pancreatic Growth Hormone-Releasing Factor-40 on Serum Growth Hormone, Prolactin, Luteinizing Hormone, Follicle-Stimulating Hormone, and Somatomedin-C Concentrations in Normal Women throughout the Menstrual Cycle* (1984)

Human pancreatic tumor GH-releasing factor-40 (hpGRF-40) selectively stimulates GH secretion in normal men and in some adults with GH deficiency. To study its effects in women, we administered hpGRF-40 (3.33 micrograms/kg) or an equivalent volume of vehicle as an iv bolus at 0900 h to 10 normal women during the early follicular, late follicular, and midluteal phases of the menstrual cycle. Serum concentrations of GH, PRL, LH, and FSH were measured at intervals between 0800-1100 h. Serum somatomedin-C concentrations were measured before and 24 h after the administration of vehicle of hpGRF-40. Within 1-3 min after the injection of hpGRF-40 all women described warmth localized to the head and neck and exhibited facial flushing. No changes in pulse rate or blood pressure were noted. When expressed as change from baseline and compared to control values, peak levels of serum GH (nanograms per ml; mean +/- SEM) were higher after hpGRF-40 treatment during the early follicular (5.4 +/- 3.2 vs. 34.9 +/- 8.3; control vs. test day; P = 0.011), late follicular (5.6 +/- 1.5 vs. 25.2 +/- 6.8; P = 0.014), and luteal (0.8 +/- 1.0 vs. 32.7 +/- 12.8; P = 0.033) phases of the menstrual cycle. Similarly, integrated serum GH levels (nanograms per ml/h) were higher after hpGRF-40 administration during the early follicular (0.72 vs. 16.1; P = 0.011), late follicular (0.83 vs. 9.9; P = 0.037), and luteal (-1.54 vs. 17.0; P = 0.036) phases of the cycle. When the increases in serum GH after hpGRF-40 treatment were compared among the phases of the menstrual cycle, however, no differences were found. Serum somatomedin-C values 24 h after hpGRF-40 treatment were higher than those 24 h after vehicle at all stages of the menstrual cycle. hpGRF-40 did not stimulate the release of PRL, LH, or FSH. We conclude that hpGRF-40 stimulates the release of GH, but that in response to the dose used, hpGRF-40-stimulated GH release does not vary during the menstrual cycle.
Signals Passing Through Asymmetric Faults in Transmission Lines (2021)

Unexpected results have been seen in multiple papers involving spread spectrum time domain reflectometry (SSTDR) measurements on twin lead cables with one line containing a fault. A small portion of the signal is able to transmit past the fault, reflect off the end of the cable, return back through the fault, and be recorded by the SSTDR. This paper explains the physics of why this can happen, and the effect of nearby ground planes. The transmission through the fault involves electric and magnetic fields coupling to nearby conductive objects. This coupling allows for a small amount of signal to move beyond the fault. We use multi-conductor transmission line theory to explain this effect. A finite difference time domain simulation of the multi-conductor system is compared to measured results to demonstrate why this effect occurs, and the effect of the nearby ground.
Spectroscopy and structure of 2-hydroxyquinoline (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpectroscopy and structure of 2-hydroxyquinolineM. R. Nimlos, D. F. Kelley, and E. R. BernsteinCite this: J. Phys. Chem. 1987, 91, 27, 6610–6614Publication Date (Print):December 1, 1987Publication History Published online1 May 2002Published inissue 1 December 1987https://pubs.acs.org/doi/10.1021/j100311a011https://doi.org/10.1021/j100311a011research-articleACS PublicationsRequest reuse permissionsArticle Views372Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Reduction in Buffer Leakage Current with Mn-Doped GaN Buffer Layer Grown by Metal Organic Chemical Vapor Deposition (2013)

The effect of Mn-doping into a GaN buffer layer grown by metal organic chemical vapor deposition (MOCVD) on the reduction in the leakage current of high-electron-mobility transistors (HEMTs) was investigated. Both the surface morphology and crystallinity maintained their quality even after heavy Mn-doping. The sheet resistance of GaN films increased with increasing amount of Mn-doping. The origin of semi-insulating GaN layer is considered to be electron scattering and the carrier compensation mechanism involving deep levels generated by the Mn impurity. When using the Mn-doped GaN buffer layer for the HEMT structure, the leakage current was reduced to five orders of magnitude lower than that without Mn-doping. Although Mn-doping is an effective technique for reducing the buffer leakage current, it is found that current collapse is emphasized when using the Mn-doped GaN buffer layer. We suggest that Mn atoms, which diffused to the GaN channel layer, induce the current collapse.
Cortical lesions in multiple sclerosis: combined postmortem MR imaging and histopathology. (2005)

In contrast to WM lesions and mixed GM-WM lesions, intracortical lesions remain largely undetected with current MR imaging resolution.
Novel Fission-Product Separation Based on Room Temperature Ionic Liquids (2005)

This presentation was given at the DOE Office of Science-Environmental Management Science Program (EMSP) High-Level Waste Workshop held on January 19-20, 2005 at the Savannah River Site.
Optical Label Swapping for IP-WDM Networks Using Self-Seeded Fabry-Perot Laser Label and Fiber Bragg Gratings (2001)

We experimentally demonstrate a simple optical label swapping technique for 10 Gb/s IP-WDM networks using the self-seeded Fabry-Perot laser label and fiber Bragg gratings. Negligible power penalty of 0.1 – 0.2 dB can be achieved for both the 120-MHz label and the swapped label. In addition, tolerable power penalty of 0.6 dB for the data payload is obtained.
Power electronics and controls for wind turbine systems (2010)

The electrical energy consumption continues to grow and more applications will be based on electricity in the next decades. We can expect that more 60% of all energy consumption will be converted and used as electricity. It is a demand that production, distribution and use of electrical energy are done as efficient as possible. Further, emerging climate changes argues to find future solutions which also are sustainable. Two major technologies will play important roles to solve parts of those future problems. One is the change the electrical power production from conventional, fossil (and short term) based energy sources to renewable energy sources. Another is to use high efficient power electronics in power generation, power transmission/distribution and end-user application. This paper discuss trends of the most emerging renewable energy sources, wind energy, which by means of power electronics is changing the future electrical infrastructure but also contributes steadily more to non-carbon based electricity production. Most focus is on the power electronics technologies used in wind turbine systems.
Thermal Conductivity of Polymer/Nano-filler Blends (2006)

To improve the thermal conductivity of an ethylene vinyl acetate copolymer, Elvax 260 was compounded with three carbon based nano-fillers. Multiwalled carbon nanotubes (MWCNT), vapor grown carbon nanofibers (CNF) and expanded graphite (EG) were investigated. In an attempt to improve compatibility between the Elvax and nanofillers, MWCNTs and EGs were modified through non covalent and covalent attachment of alkyl groups. Ribbons were extruded to form samples in which the nanofillers were aligned, and samples were also fabricated by compression molding in which the nano-fillers were randomly oriented. The thermal properties were evaluated by DSC and TGA, and mechanical properties of the aligned samples were determined by tensile testing. The degree of dispersion and alignment of the nanoparticles were investigated using high-resolution scanning electron microscopy. Thermal conductivity measurements were performed using a Nanoflash technique. The thermal conductivity of the samples was measured in both the direction of alignment as well as perpendicular to that direction. The results of this study will be presented.
Density evolution-based analysis and design of LDPC codes with a priori information (2010)

In this paper, we consider multiple access schemes with correlated sources, where a priori information, in terms of source correlation, is available at the access point (AP). In particular, we assume that each source uses a proper low-density parity-check (LDPC) code to transmit, through an additive white Gaussian noise (AWGN) channel, its information sequence to the AP. At the AP, the information sequences are recovered by an iterative decoder, with component decoders associated with the sources, which exploit the available a priori information. In order to analyze the behaviour of the considered multiple access coded system, we propose a density evolution-based approach, which allows to determine a signal-to-noise ratio (SNR) transfer chart and compute the system multi-dimensional SNR feasible region. The proposed technique, besides characterizing the performance of LDPC-coded multiple access scheme, is expedient to design optimized LDPC codes for this application.