gebhart/patrepeval huggingface dataset:
Metabolism of Monoterpenes (1981)

Previous studies have shown that the monoterpene ketone l-[G-(3)H]-menthone is reduced to the epimeric alcohols l-menthol and d-neomenthol in leaf discs of flowering peppermint (Mentha piperita L.), and that a portion of the menthol is converted to menthyl acetate while the bulk of the neomenthol is transformed to neomenthyl-beta-d-glucoside (Croteau, Martinkus 1979 Plant Physiol 64: 169-175). The metabolic disposition of the epimeric reduction products of the ketone, which is a major constituent of peppermint oil, is highly specific, in that little neomenthyl acetate and little menthyl glucoside are formed. However, when l-[3-(3)H]menthol and d-[3-(3)H]neomenthol are separately administered to leaf discs, both menthyl and neomenthyl acetates and menthyl and neomenthyl glucosides are formed with nearly equal facility, suggesting that the metabolic specificity observed with the ketone precursor was not a function of the specificity of the transglucosylase or transacetylase but rather a result of compartmentation of each stereospecific dehydrogenase with the appropriate transferase. A UDP-glucose:monoterpenol glucosyltransferse, which utilized d-neomenthol or l-menthol as glucose acceptor, was demonstrated in the 105,000g supernatant of a peppermint leaf homogenate, and the enzyme was partially purified and characterized. Co-purification of the acceptor-mediated activities, and differential activation and inhibition studies, provided strong evidence that the same UDP-glucose-dependent enzyme could transfer glucose to either l-menthol or d-neomenthol. Determination of K(m) and V for the epimeric monoterpenols provided nearly identical values. The acetylcoenzyme A:monoterpenol acetyltransferase previously isolated from peppermint extracts (Croteau, Hooper 1978 Plant Physiol 61: 737-742) was re-examined using l-[3-(3)H]menthol and d-[3-(3)H]neomenthol as acetyl acceptors, and the K(m) and V for both epimers were, again, very similar. These results demonstrate that the specific in vivo conversion of l-menthone to l-menthyl acetate and d-neomenthyl-beta-d-glucoside cannot be attributed to the selectivity of the transferases, and they clearly indicate that the metabolic specificity observed is a result of compartmentation effects.
Subthreshold Continuum Conductance Change in NbO Pt Memristor Interfaces (2016)

Bioinspired semiconductor-based devices with adaptive and dynamic properties will have many advantages over conventional static digital silicon-based technologies. The ability to compute, process, and retain information in parallel, without referencing other circuit elements, offers enhanced speed, storage density, energy efficiency, and functionality benefits. A novel crossbar microwire-based device consisting of Nb/NbO/Pt structure that exhibits neural synapse-like adaptive conductivity (i.e., synaptic plasticity) is presented. The neuromorphic memristive junction, formed at the interface between the Pt metal wire and the thermally annealed core–shell Nb–NbO wire, demonstrates 1000 times conductivity change with an effective continuum of resistance levels. The device can also be fully activated to display standard resistance switching between two states. In the subthreshold regime, the voltage flux applied through the ∼400 nm thick NbO junction is shown to have a linear relationship to the charge produced within the device. The conductance value G is a function of the total flux history applied. The linear flux–charge relationship is exploited to demonstrate the voltage–pulse invariance. This suggests that only the integrated flux produced during a voltage–pulse application determines the charge generated within the junction, regardless of the operational parameters like voltage amplitude and time interval. Variation in current onset voltage as a function of flux is discussed with reference to carrier extraction at the intrinsically doped metal–semiconductor interface. The observed flux invariance has implications in emerging neuromorphic semiconductor hardware. Enabling pulse stimuli to be designed to have equal flux through the device from nonvoltage sources such as light may increase functionality in bioinspired computing and applications.
The ecto-ATPDase CD39 is involved in the acquisition of the immunoregulatory phenotype by M-CSF-macrophages and ovarian cancer tumor-associated macrophages: Regulatory role of IL-27 (2016)

Tumor-associated macrophages (TAM) are immunosuppressive cells that can massively accumulate in the tumor microenvironment. In patients with ovarian cancer, their density is correlated with poor prognosis. Targeting mediators that control the generation or the differentiation of immunoregulatory macrophages represents a therapeutic challenge to overcome tumor-associated immunosuppression. The ectonucleotidase CD39 hydrolyzes ATP into extracellular adenosine that exhibits potent immunosuppressive properties when signaling through the A2A adenosine receptor. We report here that CD14(+) CD163(+) TAM isolated from ovarian cancer patients and macrophages generated in vitro with M-CSF, express high levels of the membrane ectonucleotidase CD39 compared to classically activated macrophages. The CD39 inhibitor POM-1 and adenosine deaminase (ADA) diminished some of the immunosuppressive functions of CD14(high) CD163(high) CD39(high) macrophages, such as IL-10 secretion. We identified the cytokine IL-27, secreted by tumor-infiltrating neutrophils, located close to infiltrating CD163(+) macrophages, as a major rheostat of CD39 expression and consequently, on the acquisition of immunoregulatory properties by macrophages. Accordingly, the depletion of IL-27 downregulated CD39 and PD-L1 expression as well as IL-10 secretion by M-CSF-macrophages. Collectively, these data suggest that CD39, drived by IL-27 and CD115 ligands in ovarian cancer, maintains the immunosuppressive phenotype of TAM. This work brings new information on the acquisition of immunosuppressive properties by tumor-infiltrating macrophages.
Vitamin B-6 Status during Childhood: Tracking from 2 Months to 11 Years of Age (1995)

To examine the development and tracking of long-term vitamin B-6 status from infancy to early adolescence, measurements of erythrocyte pyridoxal 5'-phosphate concentration (EPLP), the erythrocyte aspartate transaminase (EAST) stimulation test including measurements of basal activity (EASTo) and activation coefficient (alpha EAST), were made in a follow-up study of healthy children aged 2 (n = 139), 4 (n = 147), 6 (n = 157), 9 (n = 159) and 12 mo (n = 188) and 5 y (n = 148). The EAST stimulation test was repeated at 11 y (n = 153). Vitamin B-6 status, high during infancy, reached the adult level by 5 y of age. The 10th to 90th percentile ranges for EPLP values were 61-201 nmol/L at 4 mo, 49-101 nmol/L at 12 mo and 27-59 nmol/L at 5 y. The respective ranges for Easto were 16-24 microkat/L at 4 mo, 13-19 microkat/L at 12 mo, 9-14 microkat/L at 5 y and 25-39 microkat/L at 11 y of age. For alpha EAST values were 1.29-1.54 at 4 mo, 1.48-1.77 at 12 mo, 1.70-2.07 at 5 y and 2.00-2.57 at 11 y. Values for EPLP and the EAST stimulation test in the first year of life correlated with the values at 5 and 11 y. The individuals with values at the extreme ends of the distributions remained there from infancy to childhood up to 3.3 times more often than expected from random variation.(ABSTRACT TRUNCATED AT 250 WORDS)
VIBRATION MONITORING OF POWER DISTRIBUTION POLES (2006)

Some of the most visible and least monitored elements of our national security infrastructure are the poles and towers used for the distribution of our nation’s electrical power. Issues surrounding these elements within the United States include safety such as unauthorized climbing and access, vandalism such as nut/bolt removal or destructive small arms fire, and major vandalism such as the downing of power poles and towers by the cutting of the poles with a chainsaw or torches. The Idaho National Laboratory (INL) has an ongoing research program working to develop inexpensive and sensitive sensor platforms for the monitoring and characterization of damage to the power distribution infrastructure. This presentation covers the results from the instrumentation of a variety of power poles and wires with geophone assemblies and the recording of vibration data when power poles were subjected to a variety of stimuli. Initial results indicate that, for the majority of attacks against power poles, the resulting signal can be seen not only on the targeted pole but on sensors several poles away in the distribution network and a distributed sensor system can be used to monitor remote and critical structures.
Unacylated ghrelin and AZP531 suppress the 3D growth of breast cancers (2020)

ABSTRACT Breast cancer is the most common type of cancer in women and notwithstanding important therapeutic advances, it remains the second leading cause of cancer-related death in the US. Despite extensive research relating to the hormone ghrelin, responsible for the stimulation of growth hormone release and appetite, little is known of the effects of its unacylated form, especially in cancer. One major area of research relates to its reported effects to increase insulin sensitivity in diabetics, this being the basis for the development of unacylated ghrelin analog, AZP531 or livoletide, now in clinical trials for the treatment of Prader-Willi Syndrome. The mechanism of action of unacylated ghrelin is largely uncharacterized, in any system, because it does not bind to or activate the cognate ghrelin receptor, GHSR1a. The present study aimed to characterize effects of unacylated ghrelin on breast cancer cells, define its mechanism of action, and explore the therapeutic potential of unacylated ghrelin or analog AZP531. We report potent effects of unacylated ghrelin, at picomolar doses, on the growth of breast cancer cells, dependent on 3D culture and activation of Gαi. Suppression of MAPK signaling by unacylated ghrelin leads to cell cycle arrest and apoptosis. AZP531 also suppresses the growth of breast cancer cells in vitro and in xenografts, and may be a novel approach for the safe and effective treatment of breast cancer.
Penile neuronal nitric oxide synthase and its regulatory proteins are present in hypothalamic and spinal cord regions involved in the control of penile erection (2003)

Control of penile erection requires the coordination of the hypothalamus and the L6-S1 region of the spinal cord. Erection requires the activation of neuronal nitric oxide synthase (nNOS), which is tightly regulated. Because variants of nNOS (penile nNOS: PnNOS) and the N-methyl-D-aspartate receptor (truncated NMDAR subunit 1: NMDAR1-T) as well as protein inhibitor of NOS (PIN) have all been located in the pelvic ganglia and penile nerves, this work aims to determine whether these proteins are also present in the hypothalamus. It was found that PnNOS, the brain-type nNOS, and PIN, were expressed in the hypothalamus. In contrast, NMDAR1-T was expressed only in the penis, whereas the brain-type NMDAR1 was present in the brain and sacral spinal cord and not in the penis. PnNOS was found in the media preoptic area, posterior magnocellular, and the parvocellular regions of the paraventricular nucleus, supraoptic nucleus, septohypothalamic nucleus, medial septum, cortex, and in some of the nNOS staining neurons throughout the brain. It was absent in the organum vasculosum of the lamina terminalis. PIN staining was present in neurons of the medial preoptic area, paraventricular nucleus, medial septum, and cortex, but not in the supraoptic nucleus, septohypothalamic nucleus, or organum vasculosum of the lamina terminalis. Colocalization between PnNOS and PIN was found in the medial preoptic area, medial septum, and cortex, and less in the paraventricular nucleus. PnNOS and oxytocin were colocalized in the paraventricular nucleus and supraoptic nucleus. In hypothalamic extracts, recombinant PIN-GST protein bound to PnNOS in the extracts and partially inhibited NOS activity. These results indicate that both nNOS variants, and their respective regulatory proteins are present and colocalize in the hypothalamic and spinal cord regions involved in penile erection.
K-relevance (2007)

Applications ranging from grid management to sensor nets to web-based information integration and extraction can be viewed as receiving data from some number of autonomous remote data sources and then answering queries over this collected data. In such environments it is helpful to inform users which data sources are "relevant" to their query results. It is not immediately obvious what "relevant" should mean in this context, as different users will have different requirements. In this paper, rather than proposing a single definition of relevance, we propose a spectrum of definitions, which we term "k-relevance", for k ≥ 0. We give algorithms for identifying k-relevant data sources for relational queries and explore their efficiency both analytically and experimentally. Finally, we explore the impact of integrity constraints (including dependencies) and materialized views on the problem of computing and maintaining relevant data sources.
Synthetic Biology Open Language Visual (SBOL Visual) Version 2.0 (2018)

People who are engineering biological organisms often find it useful to communicate in diagrams, both about the structure of the nucleic acid sequences that they are engineering and about the functional relationships between sequence features and other molecular species. Some typical practices and conventions have begun to emerge for such diagrams. The Synthetic Biology Open Language Visual (SBOL Visual) has been developed as a standard for organizing and systematizing such conventions in order to produce a coherent language for expressing the structure and function of genetic designs. This document details version 2.0 of SBOL Visual, which builds on the prior SBOL Visual 1.0 standard by expanding diagram syntax to include functional interactions and molecular species, making the relationship between diagrams and the SBOL data model explicit, supporting families of symbol variants, clarifying a number of requirements and best practices, and significantly expanding the collection of diagram glyphs.
Flame-Resistant Polymers. Polyphos-phonamides, from Phosphonic Diamides (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFlame-Resistant Polymers. Polyphos-phonamides, from Phosphonic DiamidesH. W. Coover, R. L. McConnell, and N. H. ShearerCite this: Ind. Eng. Chem. 1960, 52, 5, 412–414Publication Date (Print):May 1, 1960Publication History Published online1 May 2002Published inissue 1 May 1960https://pubs.acs.org/doi/10.1021/ie50605a031https://doi.org/10.1021/ie50605a031research-articleACS PublicationsRequest reuse permissionsArticle Views68Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Improved Electrochemical Performance for High-Voltage Spinel LiNi0.5Mn1.5O4 Modified by Supercritical Fluid Chemical Deposition (2023)

Among candidates at the positive electrode of the next generation of Li-ion technology and even beyond post Li-ion technology as all-solid-state batteries, spinel LiNi<sub>0.5</sub>Mn<sub>1.5</sub>O<sub>4</sub> (LNMO) is one of the favorites. Nevertheless, before its integration into commercial systems, challenges still remain to be tackled, especially the stabilization of interfaces with the electrolyte (liquid or solid) at high voltage. In this work, a simple, fast, and cheap process is used to prepare a homogeneous coating of Al<sub>2</sub>O<sub>3</sub> type to modify the surface of the spinel LNMO: the supercritical fluid chemical deposition (SFCD) route. This process is, to the best of our knowledge, used for the first time in the battery field. Significantly improved performance was demonstrated vs those of bare LNMO, especially at high rates and for highly loaded electrodes.
Isolation and Characterization of Mutants in Plant Cell Culture (1984)

INTRODUCTION . 519 NOMENCLATURE 520 METHODS FOR THE ISOLATION OF VARIANT CELL LINES 521 BASIS OF PHENOTYPIC VARIATION IN SOMATIC CELLS 522 St�ies of SeJ;�1 Transmission to Confirm Mutation 522 Epigenetic Varrants.. . . ..... ... .. . . . ..... . . .. ...... . . .. ........ 525 CHARACTERIZATION OF DOMINANCE-RECESSIVITY RELATIONSHIPS BY CELL FUSION 526 MUTANTS AND VARIANTS 526 Auxotrophic Lines , . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .... . . . . . . . . . . .. . . . . . . . . . . 526 Chlorate Resistance-Nitrate Reductase Deficiency 527 Resistance to Amino Acids and Amino Acid Analogs 528 Res!s�an�e to !ucleic Acid Base Analogs 530 AntibIOtIC ReSistance 530 Developmental Variants 532 Herbicide Resistance 532 Salt and Water Stress Tolerance 533 Disease Tolerance 534 SOMACLONAL VARIATION . ... . . . . . . .. . . . . . . . . . . .. .... . . . . . . . . ....... . . . . . . . 535 CONCLUSIONS AND REMARKS 536
Transition metal-nitrogen-carbon catalysts for oxygen reduction reaction in neutral electrolyte (2016)

Platinum group metal-free (PGM-free) catalysts based on M-N-C types of materials with M as Mn, Fe, Co and Ni and aminoantipyrine (AAPyr) as N-C precursors were synthesized using sacrificial support method. Catalysts kinetics of oxygen reduction reaction (ORR) was studied using rotating ring disk electrode (RRDE) in neutral pH. Results showed that performances were distributed among the catalysts as: Fe-AAPyr > Co-AAPyr > Mn-AAPyr > Ni-AAPyr. Fe-AAPyr had the highest onset potential and half-wave potential. All the materials showed similar limiting current. Fe-AAPyr had an electron transfer involving 4e− with peroxide formed lower than 5%. Considering H2O2 produced, it seems that Co-AAPyr, Mn-AAPyr and Ni-AAPyr follow a 2 × 2e− mechanism with peroxide formed during the intermediate step. Durability test was done on Fe-AAPyr for 10,000 cycles. Decrease of activity was observed only after 10,000 cycles.
Thermal Performance Evaluation of Walls with AAC Blocks, Insulating Plaster, and Reflective Coating (2019)

A comparison of the thermal performance and energy efficiency of walls constructed using autoclaved aerated concrete (AAC) block with thermal insulating plaster and reflective coating and the standard hollow-core concrete block (HCB) wall is presented. The study was performed through the field monitoring of two test rooms with AAC and HCB walls located in Eastern Saudi Arabia, with weather characterized by a hot and humid climate during the summer. Weather stations, infrared cameras, thermocouples, heat flux meters, temperature/relative humidity sensors, U-value equipment, and power meters were used to assess the thermal performance and energy consumption of the two test rooms. The results indicated that the thermal resistance of AAC walls was about five times that of the HCB walls, whereas the thermal transmittance of AAC walls was reduced by 82%. The AAC blocks with insulating plaster and reflective coating tendered a 58% reduction in the energy consumption in the AAC wall test room. Simulation of the test rooms using DesignBuilder software version 5.4 captured the field results with reasonable accuracy.
Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin‐mediated photodynamic therapy (2006)

Both the commitment event and the modality of cell death in photodynamic therapy (PDT) remain poorly defined. We report that PDT with endoplasmic reticulum (ER)-associating hypericin leads to an immediate loss of SERCA2 protein levels, causing disruption of Ca2+ homeostasis and cell death. Protection of SERCA2 protein rescues ER-Ca2+ levels and prevents cell death, suggesting that SERCA2 photodestruction with consequent incapability of the ER to maintain intracellular Ca2+ homeostasis is causal to cell killing. Apoptosis is rapidly initiated after ER-Ca2+ depletion and strictly requires the BAX/BAK gateway at the mitochondria. Bax-/-Bak-/- double-knockout (DKO) cells are protected from apoptosis but undergo autophagy-associated cell death as revealed by electron microscopy and biochemical analysis. Autophagy inhibitors, but not caspase antagonists, significantly reduce death of DKO cells, suggesting that sustained autophagy is lethal. Thus, following ER photodamage and consequent disruption of Ca2+ homeostasis, BAX and BAK proteins model PDT-mediated cell killing, which is executed through apoptosis in their presence or via an autophagic pathway in their absence.
Spatial variations of hot-carrier transmission acrossCoSi2/Si interfaces on a nanometer scale (1996)

In situ ballistic-electron-emission microscopy (BEEM) and spectroscopy have been performed at 77 K on epitaxial ${\mathrm{CoSi}}_{2}$ films on n-Si(100) and Si(111) of both doping types. Two different mechanisms have been identified, by which structural defects at these interfaces give rise to variations of the carrier transmission across the interface on a nanometer scale: On ${\mathrm{CoSi}}_{2}$/Si(111) interfacial misfit dislocations locally enhance the scattering probability at the interface. By the same mechanism individual interfacial point defects can be resolved in BEEM images. No variations of the Schottky barrier have been observed at this interface. In contrast, on ${\mathrm{CoSi}}_{2}$/Si(100), certain interfacial dislocations and other defects lower the Schottky barrier by up to 0.1 eV on a nanometer scale. \textcopyright{} 1996 The American Physical Society.
Movie S2 from Assessment of Tumor Redox Status through (<i>S</i>)-4-(3-[<sup>18</sup>F]fluoropropyl)-L-Glutamic Acid PET Imaging of System x<sub>c</sub><sup>−</sup> Activity (2023)

&lt;p&gt;Movie S2&lt;/p&gt;
Non-optimistic Secure Circuit Evaluation Based on ElGamal Encryption and Its Applications (2007)

We propose a protocol for implementing secure circuit evaluation (SCE) based on the threshold homomorphic ElGamal encryption scheme and present the implementation results of the protocol. To the best of knowledge of the authors, the proposed protocol is more efficient in terms of computational complexity than previously reported protocols. We also introduce applications using SCE and estimate their practicality based on the implementation results.