gebhart/patrepeval huggingface dataset:
The Role of Stress Hormones in Perioperative Myocardial Ischemia (1992)

In this chapter I have tried to illustrate how trauma-induced changes in plasma catecholamines and other stress hormones can result in physiological alterations that may in turn increase the likelihood of developing myocardial ischemia. Data have been presented about potential mechanisms by which these hormones can lead to the development of ischemia, although additional work is required in this area. Among the strategies for modulating the stress response to surgery, the use of axial narcotics and perioperative administration of alpha 2-agonists can be easily instituted in most institutions. Additional studies are needed to determine whether these techniques reduce the incidence of perioperative ischemic complications. Because these interventions are labor intensive and therefore costly, further work is required to identify which subsets of patients may benefit from such aggressive management.
Arylimidamide DB766, a Potential Chemotherapeutic Candidate for Chagas' Disease Treatment (2010)

Chagas' disease, a neglected tropical illness for which current therapy is unsatisfactory, is caused by the intracellular parasite Trypanosoma cruzi. The goal of this work is to investigate the in vitro and in vivo effects of the arylimidamide (AIA) DB766 against T. cruzi. This arylimidamide exhibits strong trypanocidal activity and excellent selectivity for bloodstream trypomastigotes and intracellular amastigotes (Y strain), giving IC(50)s (drug concentrations that reduce 50% of the number of the treated parasites) of 60 and 25 nM, respectively. DB766 also exerts striking effects upon different parasite stocks, including those naturally resistant to benznidazole, and displays higher activity in vitro than the reference drugs. By fluorescent and transmission electron microscopy analyses, we found that this AIA localizes in DNA-enriched compartments and induces considerable damage to the mitochondria. DB766 effectively reduces the parasite load in the blood and cardiac tissue and presents efficacy similar to that of benznidazole in mouse models of T. cruzi infection employing the Y and Colombian strains, using oral and intraperitoneal doses of up to 100 mg/kg/day that were given after the establishment of parasite infection. This AIA ameliorates electrocardiographic alterations, reduces hepatic and heart lesions induced by the infection, and provides 90 to 100% protection against mortality, which is similar to that provided by benznidazole. Our data clearly show the trypanocidal efficacy of DB766, suggesting that this AIA may represent a new lead compound candidate to Chagas' disease treatment.
Time lapse microscopy observation of cellular structural changes and image analysis of drug treated cancer cells to characterize the cellular heterogeneity (2014)

The effect of Calotropis gigantea latex (CGLX) on human mammary carcinoma cells is not well established. We present the results of this drug activity at total population and single cell level. CGLX inhibited the growth of MCF7 cancer cells at lower IC50 concentration (17 µL/mL). Microscopy of IC50 drug treated cells at 24 hr confirming the appearance of morphological characteristics of apoptotic and necrotic cells, associated with 70% of DNA damage. FACS analysis confirmed that, 10 and 20% of the disruption of cellular mitochondrial nature by at 24 and 48 h, respectively. Microscopic image analysis of total population level proved that MMP changes were statistically significant with P values. The cell to cell variation was confirmed by functional heterogeneity analysis which proves that CGLX was able to induce the apoptosis without the contribution of mitochondria. We conclude that CGLX inhibits cell proliferation, survival, and heterogeneity of pathways in human mammary carcinoma cells.
MPEG-2 in a Stream Programming Language (2005)

Image and video codecs are prevalent in multimedia applications, ranging from embedded systems, to desktop computers, to high-end servers such as HDTV editing consoles. It is not uncommon however that developers create (from scratch) and customize their codec implementations for each of the architecture targets they intend their coders and decoders to run on. This practice is time consuming and error prone, leading to code that is not malleable or portable. In this paper we describe an implementation of the MPEG-2 codec using the StreamIt programming language. StreamIt is an architecture-independent stream language that aims to improve programmer productivity, while concomitantly exposing the inherent parallelism and communication topology of the application. We describe why MPEG is a good match for the streaming programming model, and illustrate the malleability of the implementation using a simple modification to the decoder to support alternate color compression formats. StreamIt allows for modular application development, which also reduces the complexity of the debugging process since stream components can be verified independently. This in turn leads to greater programmer productivity. We implement a fully functional MPEG-2 decoder in StreamIt. The decoder was developed in eight weeks by a single student programmer who did not have any prior experience with MPEG or other video codecs. Many of the MPEG-2 components were subsequently reused to assemble a JPEG codec. 1.
Pathway-Specific Defects in T, B, and NK Cells and Age-Dependent Development of High IgE in Mice Heterozygous for a CADINS-Associated Dominant Negative CARD11 Allele (2021)

CARD11 is a multidomain scaffold protein required for normal activation of NF-κB, JNK, and mTOR during Ag receptor signaling. Germline CARD11 mutations cause at least three types of primary immunodeficiency including CARD11 deficiency, B cell expansion with NF-κB and T cell anergy (BENTA), and CARD11-associated atopy with dominant interference of NF-κB signaling (CADINS). CADINS is uniquely caused by heterozygous loss-of-function CARD11 alleles that act as dominant negatives. CADINS patients present with frequent respiratory and skin infections, asthma, allergies, and atopic dermatitis. However, precisely how a heterozygous dominant negative CARD11 allele leads to the development of this CADINS-specific cluster of symptoms remains poorly understood. To address this, we generated mice expressing the CARD11 R30W allele originally identified in patients. We find that CARD11<sup>R30W/+</sup> mice exhibit impaired signaling downstream of CARD11 that leads to defects in T, B, and NK cell function and immunodeficiency. CARD11<sup>R30W/+</sup> mice develop elevated serum IgE levels with 50% penetrance that becomes more pronounced with age, but do not develop spontaneous atopic dermatitis. CARD11<sup>R30W/+</sup> mice display reduced regulatory T cell numbers, but not the Th2 expansion observed in other mice with diminished CARD11 activity. Interestingly, the presence of mixed CARD11 oligomers in CARD11<sup>R30W/+</sup> mice causes more severe signaling defects in T cells than in B cells, and specifically impacts IFN-γ production by NK cells, but not NK cell cytotoxicity. Our findings help explain the high susceptibility of CADINS patients to infection and suggest that the development of high serum IgE is not sufficient to induce overt atopic symptoms.
The Effects of Root Zone Temperature and Limestone on pH and Electrical Conductivity on New Guinea Impatiens `Celebration Orange' (2005)

The purpose of this experiment was to examine the effects of various root-zone temperatures and pH on Impatiens × hybrida , New Guinea impatiens `Celebration Orange.' Greenhouse growers need to be cognizant of the root-zone medium pH, as New Guinea impatiens are sensitive to nutrient toxicities at low pH. It is thought that limestone at low root-zone medium temperatures is not quickly activated, leading to toxicities. The objectives of this project were to determine: the effect of root-zone medium pH on foliar symptoms of iron and manganese toxicity; and the effective rates and grind size of limestone on root-zone medium pH. Various rates of limestone and different grind sizes were incorporated into a sphagnum peat moss-based medium at a range of temperatures. This experiment used a two-way thermogradient plate to maintain varying, but stable root-zone medium temperatures, ranging from 12 to 42 °C. Plant growth as well as root-zone medium pH was monitored. Changes in root-zone medium pH were monitored over time. Results indicated that the addition of moderate or high rates of limestone, 6 or 3 kg·m -3 , provided stable root-zone media pH over the course of time. Both limestone grind sizes at 325 and 100–200 mesh provided satisfactory starting and ending pH values for healthy New Guinea impatiens growth, especially between the root-zone temperatures of 30 and 18 °C. Higher and lower temperature extremes inhibited root growth, resulting in lower quality plants.
Discriminating Subsequence Discovery for Sequence Clustering (2007)

In this paper, we explore the discriminating subsequence-based clustering problem. First, several effective optimization techniques are proposed to accelerate the sequence mining process and a new algorithm, CONTOUR, is developed to efficiently and directly mine a subset of discriminating frequent subsequences which can be used to cluster the input sequences. Second, an accurate hierarchical clustering algorithm, SSC, is constructed based on the result of CONTOUR. The performance study evaluates the efficiency and scalability of CONTOUR, and the clustering quality of SSC.
Beyond Divalent Copper: A Redox Couple for Sodium Ion Battery Cathode Materials (2015)

A P2-layered oxide using copper as the active redox metal has been discovered. It has a composition of Na⅔Cu⅓Mn⅔O2, and can withstand a thousand cycles, maintaining 61% of its original capacity. We demonstrate that copper can enable not only high voltage, but also excellent stability. This work opens up a new avenue of oxide design for high energy, cost effective battery systems.
Characterization of the Triterpene Saponins of the Roots and Rhizomes of Blue Cohosh (Caulophyllum Thalictroides) (2001)

Seven triterpene saponins were isolated from n-butanol fractions of blue cohosh (Caulophyllum thalictroides) roots and rhizomes. Their structures were established by spectral ((1)H NMR, (13)C NMR, 2D-NMR, and APCI-MS) techniques and chemical reactions as hederagenin 3-O-alpha-L-arabinopyranoside (1); caulophyllogenin 3-O-alpha-L-arabinopyranoside (2); hederagenin 3-O-beta-D-glucopyranosyl-(1-->2)-alpha-L-arabinopyranoside (3); 3-O-alpha-L-arabinopyranosyl-hederagenin 28-O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyranoside (4); 3-O-alpha-L-arabinopyranosyl- caulophyllogenin 28-O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyranoside (5); 3-O-beta-D-glucopyranosyl-(1-->2)-alpha-L-arabinopyranosyl- echinocystic acid 28-O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyranoside (6); 3-O-beta-D-glucopyranosyl-(1-->2)-alpha-L-arabinopyranosyl-hederagenin 28-O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyranoside (7). All seven compounds were identified in this species for the first time.
Photochemical Mechanisms Responsible for the Versatile Application of Naphthalimides and Naphthaldiimides in Biological Systems (1997)

Despite the number and variety of their biological applications, the mechanisms of action of the photoactive naphthalenic imides have not yet been fully elucidated. In order to provide mechanistic insight, the photochemistry of several N-substituted 1,8-naphthalimides (NI) and 1,4,5,8-naphthaldiimides (NDI) has been studied using absorption and fluorescence spectroscopy and by laser flash photolysis (λexc = 355 nm). The lowest singlet state (S1) is mainly ππ* in nature for NI whereas nπ* character predominates for the NDI. This difference exerts a profound effect on subsequent reaction mechanisms: upon irradiation, only the NDI molecules can undergo intramolecular γ hydrogen abstraction. In the case of NP-III, a bishydroperoxy NDI derivative, this photoprocess (Φ = 0.03) leads to concomitant formation of an oxygen-centered radical (ε = 21 600 M-1 cm-1 at 465 nm in acetonitrile) and release of the hydroxyl radical (•OH). All the compounds studied produce the triplet state (in acetonitrile, εT ≈ 10 500−11 500 M-1 cm-1 at 470 nm for NI and 485 nm for NDI). The quantum yield of intersystem crossing was determined to be close to unity except where intramolecular γ hydrogen abstraction was possible (Φisc < 0.5). The triplet states were found to efficiently sensitize the formation of singlet oxygen (with SΔ > 0.8 for NI and > 0.5 for NDI). In the absence of quenchers, the triplet states react with the ground-state of starting material via electron-transfer with a high rate constant [k = (4−6) × 109 and 5 × 108 M-1 s-1 for NDI and NI, respectively] to give the radical anion and radical cation of the corresponding naphthalenic derivative. The high reactivity of the triplet states toward electron donors such as DABCO and their low ability for hydrogen abstraction are typical of a ππ* configuration. These mechanistic photochemistry results are discussed with regard to the photobiological effects observed for these compounds and show that the actual reaction leading to biological damage will depend on the microenvironment of the naphthalenic molecule.
Doped semiconductor nanocrystal junctions studied by Kelvin probe and non-contact atomic force microscopy (2013)

International audience
Spiral search based fast rotation estimation for efficient HEVC compression of navigation video sequences (2013)

During the development and testing of navigation systems for modern cars, the video streams of the systems-under-test are carefully observed for errors of any kind. While this observation is typically carried out manually by software engineers monitoring the video output, the complexity and variety of the latest navigation systems demand an automated analysis of system functionality. Recently published work on automated error detection for navigation systems [1] can only enfold its full functionality if video sequences can be recorded and compressed in real-time, so that the full test program can be run under lab conditions after recording. However, the rotational motion of these sequences makes efficient compression a difficult task. In this paper, we present a fast and efficient method for rotation estimation, so that rotational motion compensation and thus efficient encoding can take place. Compared to existing state of the art approaches for SIFT- or SURF-based global motion estimation, our scheme requires 1/16th of the original processing time while providing almost identical quality gains of up to 2.5dB.
A Task Grammar Approach to the Structure and Analysis of Robot Programs (1987)

THIS PAPER DESCRIBES A FORMAL REPRESENTATION FOR THE STRUCTURE AND CONTEXT OF A ROBOT TASK. THE PRINCIPAL OBJECTIVE OF THE REPRESENTATION IS TO ALLOW THE ANALYSIS OF ROBOT TASK DESCRIPTIONS FOR CORRECTNESS. THE IMPORTANCE OF HAVING AN EXPLICIT REPRESENTATION OF A TASK AND ITS STRUCTURE IN ADDITION TO AN OBJECT REPRESENTATION IS EMPHASIZED. A FORMAL-LANGUAGES APPROACH IS USED TO EXPRESS TASK STRUCTURE. ALTHOUGH AN INFORMAL SEMANTICS OF TASK REPRESENTATION IS USED IN THIS PAPER, WE DISCUSS THE USE OF A FORMAL SEMANTICS IN THE FINAL SECTION.
Skeletal Rearrangement and Acetylide Migration in the Butterfly Cluster Complexes with Formula CpWOs3(CO)11(C.tplbond.CCH2OMe) (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSkeletal Rearrangement and Acetylide Migration in the Butterfly Cluster Complexes with Formula CpWOs3(CO)11(C.tplbond.CCH2OMe)Pei-Chiun Su, Shun-Jean Chiang, Lin-Lin Chang, Yun Chi, Shie-Ming Peng, and Gene-Hsiang LeeCite this: Organometallics 1995, 14, 10, 4844–4849Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://pubs.acs.org/doi/10.1021/om00010a054https://doi.org/10.1021/om00010a054research-articleACS PublicationsRequest reuse permissionsArticle Views36Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Multiphase voltage-mode hysteretic controlled VRM with DSP control and novel current sharing (2003)

Applying the voltage-mode hysteretic control to multiphase Voltage Regulator Modules (VRMs) can satisfy many of the new and future generation of microprocessors and ICs powering requirements. This is because of the numerous advantages that can be obtained when both techniques are used. However, several challenges arise that include current sharing, multiphase control signals distribution, high-speed comparators noise sensitivity, hysteretic band accuracy and stability, VRM operation startup, and the stability of the controller operation at large load transients. Addressing these challenges cannot be easily achieved using analog and discrete components but rather DSP can be used to solve these problems. In this paper, multiphase voltage-mode hysteretic controlled VRM with DSP control and novel current sharing is proposed.
Unconventional, Amphiphilic Polymers Based on Chiral Poly(ethylene oxide) Derivatives. 2. Ordering and Assembly (1997)

The poly(ethylene oxide) derivatives 1−3 (Figure 1) arein designsynthetic analogues of coiled-coil-forming peptides. A comparative optical rotatory dispersion (ORD) study and TEM measurements have been used to investigate the ordering and assembly processes that are involved in the aggregation of these amphiphilic polymers 1−3 in H2O. ORD measurements have shown that various ethylene oxide derivatives display an inversion of optical rotation upon complexation with KSCN, i.e. upon adoption of a helical conformation. This observation has led to the proposal that polymers 1−3 are helically ordered in H2O, since the methyl-substituted polymer 3 exhibits an inversion of optical rotation on going from apolar (THF) to polar (H2O) solvents; phase separation prohibits the detection of such an inversion for the isobutyl-substituted polymers 1 and 2. TEM studies on surfaces onto which polymers 1−3 were deposited from aqueous solutions revealed granular and threadlike aggregates. The formation of the threadlike higher structures requires a directionality in the assembly process. Such a directionality could be provided by the formation of coiled-coil tertiary structures. However, substantial evidence for the formation of coiled coils or other specific tertiary structures is lacking.
Use of Nanoscale Iron and Bimetallic Particles for Environmental Remediation: A Review of Field-scale Applications (2009)

A number of field-scale remediation applications using nanoscale reactive metals have taken place since the start of the new millennium. This paper reviews the chemistry behind the use of nanoscale metals for environmental site remediation and offers a synopsis of some of the field —scale applications that have been published to date. Site reviews include those applications of nanoscale iron conducted at Trenton, NJ, Cape Canaveral Air Force Station, FL, Naval Air Station, Jacksonville, FL., and at Research Triangle Park, NC.
ChemInform Abstract: Crystal Structure of a New Polymorph of Li2FeSiO4. (2010)

Abstract A new polymorph of the title compound is synthesized by solid state reaction of Li 2 SiO 3 , Fe 1‐x O, and Fe (900 °C, 7 d followed by quenching to 25 °C).
Migrating Knowledge between Physical Scenarios based on Artificial Neural Networks (2018)

Deep learning is known to be data-hungry, which hinders its application in many areas of science when datasets are small. Here, we propose to use transfer learning methods to migrate knowledge between different physical scenarios and significantly improve the prediction accuracy of artificial neural networks trained on a small dataset. This method can help reduce the demand for expensive data by making use of additional inexpensive data. First, we demonstrate that in predicting the transmission from multilayer photonic film, the relative error rate is reduced by 46.8% (26.5%) when the source data comes from 10-layer (8-layer) films and the target data comes from 8-layer (10-layer) films. Second, we show that the relative error rate is decreased by 22% when knowledge is transferred between two very different physical scenarios: transmission from multilayer films and scattering from multilayer nanoparticles. Finally, we propose a multi-task learning method to improve the performance of different physical scenarios simultaneously in which each task only has a small dataset.
Interface trapping in (2¯01) β-Ga2O3 MOS capacitors with deposited dielectrics (2018)

The electrical properties of interfaces and the impact of post-deposition annealing have been investigated in gate oxides formed by low pressure chemical vapor deposition (LPCVD SiO2) and atomic layer deposition (Al2O3) on (2¯01) oriented n-type β-Ga2O3 single crystals. Capacitance-voltage based methods have been used to extract the interface state densities, including densities of slow ‘border’ traps at the dielectric-Ga2O3 interfaces. It was observed that SiO2-β-Ga2O3 has a higher interface and border trap density than the Al2O3-β-Ga2O3. An increase in shallow interface states was also observed at the Al2O3-β-Ga2O3 interface after post-deposition annealing at higher temperature suggesting the high temperature annealing to be detrimental for Al2O3-Ga2O3 interfaces. Among the different dielectrics studied, LPCVD SiO2 was found to have the lowest dielectric leakage and the highest breakdown field, consistent with a higher conduction band-offset. These results are important for the processing of high performance β-Ga2O3 MOS devices as these factors will critically impact channel transport, threshold voltage stability, and device reliability.
Active protection for photovoltaic DC‐boosting integration system during FRT (2019)

Compared with traditional photovoltaic (PV) power plants, PV DC‐boosting integration system faces serious DC‐bus overvoltage problem due to its special structure during the fault ride‐through (FRT). Based on the unique power‐output features of PV array, the authors describe a design of coordinated control strategy for the converters in the PV DC‐boosting integration system to maintain a stable DC voltage during FRT process. In addition, existing FRT control scheme ineluctably lowers the performance of the line protection; thus, a combination strategy of the system control and the line protection is proposed to enhance the fault discrimination ability (especially the interphase fault). A detailed model of the PV DC‐boosting integration system is created in PSCAD/EMTDC; the simulation results show that the proposed method not only realises the smooth FRT process with a stable DC bus voltage but also can reliably identify the voltage sag caused by the transmission line faults.