gebhart/patrepeval huggingface dataset:
Cloning and Developmental Analysis of Murid Spermatid-specific Thioredoxin-2 (SPTRX-2), a Novel Sperm Fibrous Sheath Protein and Autoantigen (2003)

Thioredoxins compose a growing family of proteins that participate in different cellular processes via redox-mediated reactions. We report here the cloning, developmental expression, and location of murid Sptrx-2. Mouse and rat SPTRX-2 proteins display a high homology to their human ortholog in the thioredoxin and NDP kinase domains, and the coding genes are located at syntenic positions. Northern blotting and in situ hybridization confirmed the testis-specific expression of murine Sptrx-2 mRNA, mostly in round spermatids. Immunohistochemical analysis of the 19 steps of rat spermiogenesis showed that SPTRX-2 expression becomes prominent in the cytoplasmic lobe of step 15-18 spermatids and diminishes in step 19 just before spermiation. However, in the spermatid tail, SPTRX-2 immunoreactivity increased from step 15 to 19 and was confined to the principal piece. By immunogold electron microscopy, SPTRX-2 was first detected scattered throughout the cytoplasm of the axoneme in step 14-15 spermatids, but began to be incorporated by step 16 into the fibrous sheath (FS). During steps 17-18, the labeling increased over the ribs and columns of the assembled FS. It peaked in step 19 and remained in the FS of epididymal spermatozoa. Immunoblots of isolated FS obtained from spermatozoa confirmed that SPTRX-2 is an integral component of the FS and a post-obstruction autoantigen in vasectomized rats. Our data indicate that SPTRX-2 incorporation into the FS lags well behind FS assembly, suggesting it is required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of FS proteins occurs.
Outbreak of Atypical Pertussis Detected by Polymerase Chain Reaction in Immunized Preschool-Aged Children (2009)

The main risk factors for PCR positivity for B. pertussis were school or day care attendance. Atypical symptoms were likely moderated by high immunization rates or may have been caused by other respiratory pathogens. In some cases, a positive PCR result might simply have reflected transient nasopharyngeal carriage of B. pertussis.
Low Levels of Peripheral CD161++CD8+ Mucosal Associated Invariant T (MAIT) Cells Are Found in HIV and HIV/TB Co-Infection (2013)

The frequencies and phenotype of CD161++CD8+ T cells in this South African cohort are comparable to those published in European and US cohorts. Low-levels of this population were associated with acute and chronic HIV infection. Lower levels of the tissue-trophic CD161++ CD8+ T cell population may contribute to weakened mucosal immune defense, making HIV-infected subjects more susceptible to pulmonary and gastrointestinal infections and detrimentally impacting on host defense against TB.
<title>Laser-induced bandgap collapse in GaAs</title> (1994)

We present recent time-resolved measurements of the linear dielectric constant of GaAs at 2.2 eV and 4.4 eV following femtosecond laser pulse excitation. In sharp contrast to predictions based on the widely used Drude model, the data show an interband absorption peak coming into resonance first with the 4.4 eV probe photon energy and then with the 2.2 eV probe photon energy, indicating major changes in the band structure. The time scale for these changes ranges from within 100 fs to a few picoseconds, depending on the incident pump pulse fluence.
The effect of low level laser therapy on ventilator-induced lung injury in mice (Conference Presentation) (2016)

Although mechanical ventilation (MV) is necessary to support gas exchange in critically ill patients, it can contribute to the development of lung injury and multiple organ dysfunction. It is known that high tidal volume (Vt) MV can cause ventilator-induced lung injury (VILI) in healthy lungs and increase the mortality of patients with Acute Respiratory Distress Syndrome. Low level laser therapy (LLLT) has demonstrated to have anti-inflammatory effects. We investigated whether LLLT could alleviate inflammation from injurious MV in mice. Adult mice were assigned to 2 groups: VILI+LLLT group (3 h of injurious MV: Vt=25-30 ml/kg, respiratory rate (RR)=50/min, positive end-expiratory pressure (PEEP)=0 cmH20, followed by 3 h of protective MV: Vt=9 ml/kg, RR=140/min, PEEP=2 cmH20) and VILI+no LLLT group. LLLT was applied during the first 30 min of the MV (810 nm LED system, 5 J/cm2, 1 cm above the chest). Respiratory impedance was measured in vivo with forced oscillation technique and lung mechanics were calculated by fitting the constant phase model. At the end of the MV, bronchoalveolar lavage (BAL) was performed and inflammatory cells counted. Lungs were removed en-bloc and fixed for histological evaluation. We hypothesize that LLLT can reduce lung injury and inflammation from VILI. This therapy could be translated into clinical practice, where it can potentially improve outcomes in patients requiring mechanical ventilation in the operating room or in the intensive care units.
Production of hydrogen by ultraviolet irradiation of tetrasulfatodimolybdate(4-) ion in aqueous sulfuric acid. Electronic absorption spectrum of tripotassium tetrasulfatodimolybdate-3.5-water at 15 K (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProduction of hydrogen by ultraviolet irradiation of tetrasulfatodimolybdate(4-) ion in aqueous sulfuric acid. Electronic absorption spectrum of tripotassium tetrasulfatodimolybdate-3.5-water at 15 KDavid K. Erwin, Gregory L. Geoffroy, Harry B. Gray, George S. Hammond, Edward I. Solomon, William C. Trogler, and Arnis A. ZagarsCite this: J. Am. Chem. Soc. 1977, 99, 11, 3620–3621Publication Date (Print):May 1, 1977Publication History Published online1 May 2002Published inissue 1 May 1977https://pubs.acs.org/doi/10.1021/ja00453a017https://doi.org/10.1021/ja00453a017research-articleACS PublicationsRequest reuse permissionsArticle Views139Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Deletion ofBCY1from theSaccharomyces cerevisiaeGenome Is Semidominant and Induces Autolytic Phenotypes Suitable for Improvement of Sparkling Wines (2006)

Autolysis of Saccharomyces cerevisiae is the main source of molecules that contribute to the quality of sparkling wines made by the traditional method. In this work the possibility of accelerating this slow process in order to improve the quality of sparkling wines by using genetically engineered wine yeast strains was explored. The effect of partial or total deletion of BCY1 (which encodes a regulatory subunit of cAMP-dependent protein kinase A) in haploid and diploid (heterozygous and homozygous) yeast strains was studied. We proved that heterozygous strains having partial or complete BCY1 deletions have a semidominant phenotype for several of the properties studied, including autolysis under simulated second-fermentation conditions, in contrast to previously published reports describing mutations in BCY1 as recessive. Considering the degree of autolysis, ethanol tolerance, and technical feasibility, we propose that deletion of the 3' end of the open reading frame of a single copy of BCY1 is a way to improve the quality of sparkling wines.
Field installation and evaluation of a 20kw rooftop PV system using 3.5kw string level MPPT DC/DC converters and a central inverter (2013)

High energy yield has been and continues to be a major driver in PV installations. With the continuous improvement in PV modules' performance, there is a need to extract as much power as possible from the modules under various weather conditions. Over the past three years, we proposed, analyzed, built, installed, and monitored a PV system with string level MPPT dc/dc converters and a central inverter to understand and quantify the benefits of distributed MPPT. Our team performed detailed simulation studies on multiple architectures (module level to multi-string level MPPT), quantified the benefits of each architecture, selected an approach (string level), and designed a novel high efficiency partial power dc/dc converter, built it and tested it in the lab (with a PV emulator) and in the field with actual PV strings and a grid tied inverter. A rooftop installation was built with two systems side by side (a distributed and a central inverter) and has been monitored over the past 9 months.
Detection of HERV-K(HML-2) Viral RNA in Plasma of HIV Type 1-Infected Individuals (2006)

Approximately 8% of the human genome sequence is composed by human endogenous retroviruses (HERVs), most of which are defective. HERV-K(HML-2) is the youngest and most active family and has maintained some proviruses with intact open reading frames (ORFs) that code for viral proteins that may assemble into viral particles. Many HERV-K(HML-2) sequences are polymorphic in humans (present in some individuals but not in others) and probably many others may be unfixed (not inserted permanently in a specific chromosomal location of the human genome). In the present study HIV-1 and HCV-1-positive plasma samples were screened for the presence of HERV-K(HML-2) RNA in an RT-PCR using HERV-K pol specific primers. HERV-K(HML-2) viral RNA sequences were found almost universally in HIV-1(+) plasma samples (95.33%) but were rarely detected in HCV-1 patients (5.2%) or control subjects (7.69%). Other HERV-K(HML-2) viral segments of the RNA genome including gag, prt, and both env regions, surface (su), and transmembrane (tm) were amplified from HERV-K pol-positive plasma of HIV-1 patients. Type 1 and type 2 HERV-K(HML- 2) viral RNA genomes were found to coexist in the same plasma of HIV-1 patients. These results suggest the HERV-K(HML-2) viral particles are induced in HIV-1-infected individuals.
Tubular Shape Aware Data Generation for Semantic Segmentation in Medical Imaging (2020)

Chest X-ray is one of the most widespread examinations of the human body. In interventional radiology, its use is frequently associated with the need to visualize various tube-like objects, such as puncture needles, guiding sheaths, wires, and catheters. Detection and precise localization of these tube-like objects in the X-ray images is, therefore, of utmost value, catalyzing the development of accurate target-specific segmentation algorithms. Similar to the other medical imaging tasks, the manual pixel-wise annotation of the tubes is a resource-consuming process. In this work, we aim to alleviate the lack of the annotated images by using artificial data. Specifically, we present an approach for synthetic data generation of the tube-shaped objects, with a generative adversarial network being regularized with a prior-shape constraint. Our method eliminates the need for paired image--mask data and requires only a weakly-labeled dataset (10--20 images) to reach the accuracy of the fully-supervised models. We report the applicability of the approach for the task of segmenting tubes and catheters in the X-ray images, whereas the results should also hold for the other imaging modalities.
Comparative Evaluation of Three-Phase High-Power-Factor AC–DC Converter Concepts for Application in Future More Electric Aircraft (2005)

A passive 12-pulse rectifier system, a two-level, and a three-level active three-phase pulsewidth-modulation (PWM) rectifier system are analyzed for supplying the dc-voltage link of a 5-kW variable-speed hydraulic pump drive of an electro-hydrostatic actuator to be employed in future More Electric Aircraft. Weight, volume, and efficiency of the concepts are compared for an input phase voltage range of 98-132 V and an input frequency range of 400-800 Hz. The 12-pulse system shows advantages concerning volume, efficiency, and complexity but is characterized by a high system weight. Accordingly, the three-level PWM rectifier is identified as the most advantageous solution. Finally, a novel extension of the 12-pulse rectifier system by turn-off power semiconductors is proposed which allows a control of the output voltage and, therefore, eliminates the dependency on the mains and load condition which constitutes a main drawback of the passive concept.
Vicenza International Courses on hemodialysis: Educational events where science meets clinical practice (2011)

Abstract International Vicenza Courses represent important educational events held yearly in the city of Palladio. Claudio Ronco organizes since 1982 international courses on peritoneal dialysis, hemodialysis and critical care nephrology. The faculty is outstanding and the content very informative and useful for beginners and for experts in the various fields. Every year the entire course is recorded in a DVD and the proceedings are available at the beginning of the course. Information can be obtained at http://www.vicenzanephrocourses.com .
MiTAP for real users, real data, real problems (2003)

The MiTAP system was developed as an experimental prototype using human language technologies for monitoring disease outbreaks. The system provides timely, multi-lingual, global information access to analysts, medical experts and individuals involved in humanitarian assistance. Thousands of articles from electronic information sources spanning multiple languages are automatically captured, translated, tagged, summarized, and presented to users in a variety of ways. Real users access MiTAP daily to solve real problems. The successful adoption of MiTAP is attributed to its user-focused design that accommodates the imperfect component technologies and allows users to interact with the system in familiar ways. We will discuss the problem, design process, and implementation from the perspective of services provided and how these services support system capabilities that satisfy user requirements.
Neural markers of suppression in impaired binocular vision (2020)

Abstract Objective/Purpose Even after conventional patching treatment, individuals with a history of amblyopia typically lack good stereo vision. This is often attributed to atypical suppression between the eyes, yet the specific mechanism is still unclear. Guided by computational models of binocular vision, we tested explicit predictions about how neural responses to contrast might differ in individuals with impaired binocular vision. Design A 5 × 5 factorial repeated measures design was used, in which all participants completed a set of 25 conditions (stimuli of different contrasts shown to the left and right eyes). Participants 25 individuals with a history of amblyopia, and 19 control participants with typical visual development, participated in the study. Methods Neural responses to different combinations of contrast in the left and right eyes, were measured using both electroencephalography (EEG) and functional magnetic resonance imaging (fMRI). Stimuli were sinusoidal gratings with a spatial frequency of 3c/deg, flickering at 4Hz. In the fMRI experiment, we also ran population receptive field and retinotopic mapping sequences, and a phase-encoded localiser stimulus, to identify voxels in primary visual cortex (V1) sensitive to the main stimulus. Main outcome measures The main outcome measures were the signal-to-noise ratio of the steady state visual evoked potential, and the fMRI β weights from a general linear model. Results Neural responses generally increased monotonically with stimulus contrast. When measured with EEG, responses were attenuated in the weaker eye, consistent with a fixed tonic suppression of that eye. When measured with fMRI, a low contrast stimulus in the weaker eye substantially reduced the response to a high contrast stimulus in the stronger eye. This effect was stronger than when the stimulus-eye pairings were reversed, consistent with unbalanced dynamic suppression between the eyes. Conclusions Measuring neural responses using different methods leads to different conclusions about visual differences in individuals with impaired binocular vision. Both of the atypical suppression effects may relate to binocular perceptual deficits, e.g. in stereopsis, and we anticipate that these measures could be informative for monitoring the progress of treatments aimed at recovering binocular vision.
The potential of cationic photopolymerization's long lived active centers (2008)

Approved: ______________________________ Thesis Supervisor ______________________________ Title and Department ______________________________ Date THE POTENTIAL OF CATIONIC PHOTOPOLYMERIZATION’S LONG LIVED ACTIVE CENTERS
119Sn-Mössbauer Study on the Normal Lattice Vibration of Superconducting Bi(Pb)2Sr2Ca2Cu3Sn0.015O10-y (1991)

The 119 Sn-Mössbauer spectrum of superconducting Bi(Pb) 2 Sr 2 Ca 2 Cu 3 Sn 0.015 O 10- y ceramic, having the T c of 108 K, consists of an intense doublet peak with the δ of 0.18 mm·s -1 and the Δ of 1.01 mm·s -1 at room temperature. The δ and Δ indicate that the Sn 4+ is substituted for the copper ion in the triangular CuO 3 site of the CuO 4 layer. The δ and the absorption area increase gradually with decreasing temperature and become saturated at about 30 K, being consistent with the theoretical curves obtained from the “combined Debye and Einstein model”. Only the normal vibration without the softening is observed in the CuO 4 layer.
Aptamer‑based therapy for targeting key mediators of cancer metastasis (Review) (2022)

Cancer‑related deaths remain a challenging and devastating obstacle to defeat despite the tremendous advances in cancer treatment. Cancer metastasis is the major cause of these cancer‑related deaths. Metastasis involves sequential steps during cancer cells' journey to a new site. These steps are coordinately regulated by specific intracellular regulators and cellular interactions between the cancer cells and the supporting microenvironment of the different organs. The development of aptamer‑based therapeutics is a promising strategy to fight cancer metastasis as it holds potential advantages. Oligonucleotide and peptide aptamers are short sequences of single‑stranded nucleic acids or amino acids, respectively, that target proteins, genetic materials, and cells. Antimetastatic aptamer‑based therapeutics exert their pharmacological effect by direct interaction with the signaling pathways inside the cancer cells or the communications between cancer cells and the tumor microenvironment. In addition, aptamers have been utilized as a guiding ligand to deliver a therapeutic moiety to cancer cells or the supporting microenvironment. The selected aptamer possesses high specificity since it is designed to recognize and interact with its target. This review summarizes recent advances in the development of aptamer‑based therapeutics targeting mediators of cancer metastasis. In addition, potential opportunities are discussed to inspire researchers in the field to develop novel aptamer‑based antimetastatic treatments.
Catalytic Asymmetric Syntheses of α-Amino and α-Hydroxyl Acid Derivatives (2009)

Herein we report the first room temperature Heck reaction of aryl bromides and CH(2)=C(NHP)CO(2)Me (P = Boc or CBz) to form ArCH=C(NHP)CO(2)Me, which are then used for the asymmetric syntheses of alpha-amino acids. We also report the first syntheses of ArCH=C(OCOAr(1))CO(2)Me (Ar(1) = Ph, 4-Cl-Ph) from ArBr and CH(2)=C(OCOAr(1))CO(2)Me by the Heck reaction and subsequent successful asymmetric hydrogenation to afford alpha-hydroxyl esters in excellent chemical yields and good-to-excellent enantioselectivities.
A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid (2020)

Human ornithine aminotransferase (<i>h</i>OAT), a pyridoxal 5'-phosphate-dependent enzyme, plays a critical role in the progression of hepatocellular carcinoma (HCC). Pharmacological selective inhibition of <i>h</i>OAT has been shown to be a potential therapeutic approach for HCC. Inspired by the discovery of the nonselective aminotransferase inactivator (1<i>R</i>,3<i>S</i>,4<i>S</i>)-3-amino-4-fluoro cyclopentane-1-carboxylic acid (<b>1</b>), in this work, we rationally designed, synthesized, and evaluated a novel series of fluorine-substituted cyclohexene analogues, thereby identifying <b>8</b> and <b>9</b> as novel selective <i>h</i>OAT time-dependent inhibitors. Intact protein mass spectrometry and protein crystallography demonstrated <b>8</b> and <b>9</b> as covalent inhibitors of <i>h</i>OAT, which exhibit two distinct inactivation mechanisms resulting from the difference of a single fluorine atom. Interestingly, they share a similar turnover mechanism, according to the mass spectrometry-based analysis of metabolites and fluoride ion release experiments. Molecular dynamics (MD) simulations and electrostatic potential (ESP) charge calculations were conducted, which elucidated the significant influence of the one-fluorine difference on the corresponding intermediates, leading to two totally different inactivation pathways. The novel addition-aromatization inactivation mechanism for <b>9</b> contributes to its significantly enhanced potency, along with excellent selectivity over other aminotransferases.
Attribution Modeling Increases Efficiency of Bidding in Display Advertising (2017)

Predicting click and conversion probabilities when bidding on ad exchanges is at the core of the programmatic advertising industry. Two separated lines of previous works respectively address i) the prediction of user conversion probability and ii) the attribution of these conversions to advertising events (such as clicks) after the fact. We argue that attribution modeling improves the efficiency of the bidding policy in the context of performance advertising.
Effect of Long-term Ingestion of Chicken Extract on Muscular Power for Middle and Advanced Age Groups (2012)

カルノシン，アンセリンを高濃度に含有する鶏肉抽出物の摂取が，中高齢者の筋力にもたらす影響を検討した．中高齢者20名を2群に分け，鶏肉抽出物をそれぞれ一日量に1 500 mg（カルノシン，アンセリンの合計量として225 mg）もしくは0 mgを4週間継続摂取させた．摂取期間の前後に，等速性膝最大伸展力，膝最大屈曲力，および開眼片足立ちの保持時間を測定した．その結果，鶏肉抽出物群において，有意な膝最大伸展力の向上，開眼片足立ち保持時間の延長が認められた．これらの結果より，カルノシン，アンセリンを含有する鶏肉抽出物の摂取は，中高齢者の筋力の向上に有効であると考えられた．