gebhart/patrepeval huggingface dataset:
Tripartite Symbiosis of an Anaerobic Scuticociliate with Two Hydrogenosome-Associated Endosymbionts, a Holospora -Related Alphaproteobacterium and a Methanogenic Archaeon (2019)

A number of anaerobic ciliates, unicellular eukaryotes, intracellularly possess methanogenic archaea and bacteria as symbiotic partners. Although this tripartite relationship is of interest in terms of the fact that each participant is from a different domain, the difficulty in culture and maintenance of those host species with symbiotic partners has disturbed both ecological and functional studies so far. In this study, we obtained a stable culture of a small anaerobic scuticociliate, strain GW7. By transmission electron microscopic observation and fluorescent <i>in situ</i> hybridization with domain-specific probes, we demonstrate that GW7 possesses both archaeal and bacterial endosymbionts in its cytoplasm. These endosymbionts are in dependently associated with hydrogenosomes, which are organelle producing hydrogen and ATP under anaerobic conditions. Clone library analyses targeting prokaryotic 16S rRNA genes, fluorescent <i>in situ</i> hybridization with endosymbiont-specific probes, and molecular phylogenetic analyses revealed the phylogenetic affiliations and intracellular localizations of these endosymbionts. The endosymbiotic archaeon is a methanogen belonging to the genus <i>Methanoregula</i> (order <i>Methanomicrobiales</i>); a member of this genus has previously been described as the endosymbiont of an anaerobic ciliate from the genus <i>Metopus</i> (class Armophorea), which is only distantly related to strain GW7 (class Oligohymenophorea). The endosymbiotic bacterium belongs to the family <i>Holosporaceae</i> of the class <i>Alphaproteobacteria</i>, which also comprises several endosymbionts of various aerobic ciliates. For this endosymbiotic bacterium, we propose a novel candidate genus and species, "<i>Candidatus</i> Hydrogenosomobacter endosymbioticus."<b>IMPORTANCE</b> Tripartite symbioses between anaerobic ciliated protists and their intracellular archaeal and bacterial symbionts are not uncommon, but most reports have been based mainly on microscopic observations. Deeper insights into the function, ecology, and evolution of these fascinating symbioses involving partners from all three domains of life have been hampered by the difficulties of culturing anaerobic ciliates in the laboratory and the frequent loss of their prokaryotic partners during long-term cultivation. In the present study, we report the isolation of an anaerobic scuticociliate, strain GW7, which has been stably maintained in our laboratory for more than 3 years without losing either of its endosymbionts. Unexpectedly, molecular characterization of the endosymbionts revealed that the bacterial partner of GW7 is phylogenetically related to intranuclear endosymbionts of aerobic ciliates. This strain will enable future genomic, transcriptomic, and proteomic analyses of the interactions in this tripartite symbiosis and a comparison with endosymbioses in aerobic ciliates.
Control of Systems with Infinitely Many Unstable Modes and Strongly\n Stabilizing Controllers Achieving a Desired Sensitivity (2020)

In this paper we consider a class of linear time invariant systems with\ninfinitely many unstable modes. By using the parameterization of all\nstabilizing controllers, we show that H-infinity controllers for such systems\ncan be computed using the techniques developed earlier for infinite dimensional\nplants with finitely many unstable modes. We illustrate connections between the\nproblem solved here and an indirect method for strongly stabilizing H-infinity\ncontroller design for systems with time delays.\n
Optimal scaling quantum linear systems solver via discrete adiabatic theorem (2021)

Recently, several approaches to solving linear systems on a quantum computer have been formulated in terms of the quantum adiabatic theorem for a continuously varying Hamiltonian. Such approaches enabled near-linear scaling in the condition number $κ$ of the linear system, without requiring a complicated variable-time amplitude amplification procedure. However, the most efficient of those procedures is still asymptotically sub-optimal by a factor of $\log(κ)$. Here, we prove a rigorous form of the adiabatic theorem that bounds the error in terms of the spectral gap for intrinsically discrete time evolutions. We use this discrete adiabatic theorem to develop a quantum algorithm for solving linear systems that is asymptotically optimal, in the sense that the complexity is strictly linear in $κ$, matching a known lower bound on the complexity. Our $\mathcal{O}(κ\log(1/ε))$ complexity is also optimal in terms of the combined scaling in $κ$ and the precision $ε$. Compared to existing suboptimal methods, our algorithm is simpler and easier to implement. Moreover, we determine the constant factors in the algorithm, which would be suitable for determining the complexity in terms of gate counts for specific applications.
Enantioselective Addition of Aldehydes to Amines via Combined Catalytic Biomimetic Oxidation and Organocatalytic C—C Bond Formation. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Robot-Assisted Microsurgery Development at JPL (2003)

Microsurgeons use a microscope with 20 to 30 times magnification to help them visualize the microscopic field they work with. However, they still use their hands to hold instruments that manipulate tissue with feature sizes from fifty to a few hundred microns. A microsurgical manipulator that can scale down the surgeon's hand motions to the microscopic field would allow the average surgeon to perform at the level of the best surgeons and allow the most skillful surgeons to perform at unprecedented levels of dexterity. Development of practical systems for assisting microsurgeons in this way is a growing field of research. Microtelerobotic workstations systems that have been developed for biomedical applications. The work reported here is the result of collaboration between researchers at the Jet Propulsion Laboratory (JPL) and Steve Charles, a vitreo-retinal surgeon. The Robot-Assisted Microsurgery (RAMS) telerobotic workstation developed at JPL is a prototype of a system that will be completely under the manual control of a surgeon. It is unique in its combination of compact size, light weight, and high precision. The system, has a slave robot that holds surgical instruments. The surgeon commands motions for the instrument by moving the handle on a master device in the desired trajectories. The trajectories are measured, filtered, and scaled down then used to drive the slave robot. We present the details of this telerobotic system by first giving an overview of the subsystems and their interactions and then presenting details. The chapter concludes with a description of a recent demonstration of a simulated microsurgery procedure performed at JPL.
To Treat Hepatic Coma in Malignancy? (1971)

Letters and Comments1 July 1971To Treat Hepatic Coma in Malignancy?JACOB RAJFERJACOB RAJFERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-1-142 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I read with interest the article by Eras and Sherlock in the April 1971 issue of the ANNALS, where they conclude that "Clearly, metastatic liver disease may result in hepatic coma. Its early recognition should result in rapid institution of a hepatic coma regimen. Narcotics . . . should be avoided when possible since they may aggravate the hepatic coma."Why would the authors or any other physician recommend treatment of hepatic coma in a patient with metastatic hepatic carcinoma? Isn't this [hepatic coma] a more humane way of dying? Why institute heroic treatment, avoid narcotics, and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JACOB RAJFER PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1971Volume 75, Issue 1Page: 142-142KeywordsComaLiver diseases ePublished: 1 December 2008 Issue Published: 1 July 1971 PDF downloadLoading ...
Effects of feeding low protein diets to piglets on plasma urea nitrogen, faecal ammonia nitrogen, the incidence of diarrhoea and performance after weaning (2008)

This study evaluated the effects of feeding pigs low protein (LP) diets for different lengths of time after weaning on indices of protein fermentation, the incidence of postweaning diarrhoea (PWD), growth performance, and total-tract apparent digestibility. Sixty weaner pigs weighing 6.1 +/- 0.13 kg (mean +/- SEM) were used in a completely randomised design having five treatments: (i) a high protein diet (HP, 243 g/kg CP) fed for 14 d after weaning (HP14); (ii) a low protein diet (LP, 173 g CP/kg) fed for 5 d after weaning (LP5); (iii) LP diet fed for 7 d after weaning (LP7); (iv) LP diet fed for 10 d after weaning (LP10), and (v) LP diet fed for 14 d after weaning (LP14). All diets were supplemented with lysine, methionine, tryptophan and threonine, with all LP diets additionally fortified with crystalline isoleucine and valine to conform to a proposed ideal amino acid (AA) pattern. A second-stage diet (215 g CP/kg) was fed to pigs at the conclusion of each treatment. None of the diets contained antimicrobial compounds. Feeding a LP diet, regardless of duration of feeding, decreased plasma urea nitrogen (p < 0.001) and faecal ammonia-nitrogen (p < 0.001) contents. Feeding a LP diet, irrespective of feeding duration, decreased the incidence of PWD at day 8 after weaning (p = 0.044), and pigs fed diets LP7, LP010 and LP14 had firmer faeces (p = 0.030, p = 0.047 and p = 0.007, respectively) between days 10 and 12 after weaning. Treatments LP5, LP7, LP10 and LP14 did not reduce (p > 0.05) growth performance up to 106 days after weaning compared to pigs fed the HP diet. Total-tract apparent digestibility of dry matter, energy and crude protein were similar (p > 0.05) between treatments. Our data suggest that feeding a LP diet, supplemented with AA to conform to an ideal AA pattern, for 7-10 days after weaning can reduce PWD in pigs fed antibiotic-free diets without compromising production.
Propranolol in the Management of Airway Infantile Hemangiomas (2010)

Our 3 patients had severe respiratory symptoms related to their airway infantile hemangiomas. In the first patient, propranolol was used when other treatments were ineffective or associated with intolerable adverse effects. In the second and third patients, propranolol was part of a dual regimen that resulted in rapid resolution of airway symptoms and allowed for quicker weaning of corticosteroids.
Hybrid Attribute- and Re-Encryption-Based Key Management for Secure and Scalable Mobile Applications in Clouds (2013)

Outsourcing data to the cloud are beneficial for reasons of economy, scalability, and accessibility, but significant technical challenges remain. Sensitive data stored in the cloud must be protected from being read in the clear by a cloud provider that is honest-but-curious. Additionally, cloud-based data are increasingly being accessed by resource-constrained mobile devices for which the processing and communication cost must be minimized. Novel modifications to attribute-based encryption are proposed to allow authorized users access to cloud data based on the satisfaction of required attributes such that the higher computational load from cryptographic operations is assigned to the cloud provider and the total communication cost is lowered for the mobile user. Furthermore, data re-encryption may be optionally performed by the cloud provider to reduce the expense of user revocation in a mobile user environment while preserving the privacy of user data stored in the cloud. The proposed protocol has been realized on commercially popular mobile and cloud platforms to demonstrate real-world benchmarks that show the efficacy of the scheme. A simulation calibrated with the benchmark results shows the scalability potential of the scheme in the context of a realistic workload in a mobile cloud computing system.
Head injury metric response in finite element ATDs and a human body model in multidirectional loading regimes (2019)

<b>Objective:</b> The objective was to quantify head injury metric sensitivity of the 50th percentile male Hybrid III, THOR, and Global Human Body Models Consortium simplified occupant (GHBMC M50-OS) to changes in loading conditions in loading regimes that may be experienced by occupants of spaceflight vehicles or highly autonomous vehicles (HAVs) with nontraditional seating configurations.<b>Methods:</b> A Latin hypercube (LHD) design of experiments (DOE) was employed to develop boundary conditions for 455 unique acceleration profiles. Three previously validated finite element (FE) models of the Hybrid III anthropomorphic test device (ATD), THOR ATD, and GHBMC M50-OS were positioned in an upright 90°-90°-90° seat and with a 5-point belt. Acceleration pulses were applied to each of the three occupants in the ± X, +Y, and ± Z directions, with peak resultant acceleration magnitudes ranging from 5 to 20 G and times to peak ranging from 32.5 to 120.8 ms with duration 250 ms, resulting in 1,248 simulations. Head injury metrics included peak linear head acceleration, peak rotational head acceleration, head injury criteria (HIC15), and brain injury criteria (BrIC). Injury metrics were regressed against boundary condition parameters using 2nd order multiple polynomial regression, and compared between occupants using matched pairs Wilcoxon signed rank analysis.<b>Results:</b> Across the 416 matched-simulations that reached normal termination with all three models, HIC15 values ranged from 1.0-396.5 (Hybrid III), 1.2-327.9 (THOR), and 0.6-585.6 (GHBMC). BrIC ranged from 0.03-0.95 (Hybrid III), 0.03-1.21 (THOR), and 0.04-0.84 (GHBMC). Wilcoxon signed rank analysis demonstrated significant pairwise differences between each of the three occupant models for head injury metrics. For HIC15, the largest divergence between GHBMC and the ATDs was observed in simulations with components of combined underbody and rear impact loading. The three models performed most similarly with respect to BrIC output when loaded in a frontal direction. Both the GHBMC and the Hybrid III produced lower values of BrIC than the THOR on average, with the differences most pronounced in rear impact loading.<b>Conclusion:</b> In conclusion, observed differences between the occupant models' head injury metric output were quantified. Loading direction had a large effect on metric outcome and metric comparability across models, with frontal and rear impacts with low vertical acceleration tending to be the most similar. One explanation for these differences could be the differences in neck stiffness between the models that allowed more rotation in the GHBMC and THOR. Care should be taken when using ATDs as human volunteer surrogates in these low energy events.
La guerra en Europa oriental (1998)

The syndrome of acute bilateral basal ganglia lesions is a rarely described complication of uremia occurring typically in the setting of concurrent long-standing diabetes mellitus. Reversible symmetrical lesions located in basal ganglia found on brain magnetic resonance imaging are hallmarks of this syndrome. Clinical presentation includes parkinsonism and/or involuntary movements. The cause of this syndrome is largely unknown. Among the factors that are believed to contribute to its pathogenesis are uremic toxins, metabolic acidosis and diabetic microangiopathy. Here we report a patient with uremia and newly diagnosed diabetes, who developed the syndrome of acute bilateral basal ganglia lesions after an incidence of severe hypoglycemia induced by oral hypoglycemic agents. We consider hypoglycemia as a candidate trigger factor for the syndrome of acute bilateral basal ganglia lesions and highlight the importance of strict glucose control in uremic patients.
Discovery of NovelN-Substituted Oxindoles as Selective M1and M4Muscarinic Acetylcholine Receptors Partial Agonists (2013)

Activation of the M1 and M4 muscarinic acetylcholine receptors is thought to play an important role in improving the symptoms of schizophrenia. However, discovery of selective agonists for these receptors has been a challenge, considering the high sequence homology and conservation of the orthosteric acetylcholine binding site among muscarinic acetylcholine receptor subtypes. We report in this study the discovery of novel N-substituted oxindoles as potent muscarinic acetylcholine receptor partial agonists selective for M1 and M4 over M2, M3, and M5. Among these oxindoles, compound 1 showed high selectivity for the M1 and M4 receptors with remarkable penetration into the central nervous system. Compound 1 reversed methamphetamine- and apomorphine-induced psychosis-like behaviors with low potency to extrapyramidical and peripheral side effects.
Integrated design method of force and current control systems (2014)

This paper studies an integrated design method of sensorless force control and current control systems. The force control gain, the estimation bandwidth and quality factor of a 1st-order disturbance observer, the proportional and integral gain of an I-P current controllers are determined analytically and numerically by Pole assignment method and Coefficient diagram method(CDM). In the case of Pole assignment and CDM, the force responses converge with the force command without any oscillations and overshoot. By the simulations and experiment, the validity of the integrated design method proposed in this paper is verified. Furthermore, this paper presents that not only the parameters of the force control system but also the gain of the I-P current controllers have to be varied depending on the environmental stiffness.
Multi-Parameter Optical Fiber Sensor for Simultaneous Corrosion and Humidity Monitoring (2021)

Corrosion 2021 (Conference), Virtual, April 19-30, 2021
Prevalence of chronic kidney disease in patients with suspected sleep apnoea (2009)

eGFR is reduced in patients with SA, particularly in those with episodes of CSA.
Bio-inspired large cellular neural networks (2007)

In this paper, we discuss the mathematics, electronic hardware, and network software aspects of the HYper-Distributed Robotic Autonomy (HYDRA) bio-inspired large neural network, proposed in a previous paper.
SOI FinFET nFET-to-pFET Tracking Variability Compact Modeling and Impact on Latch Timing (2015)

In this paper, nFET-to-pFET (n-to-p) tracking characteristics in 14-nm silicon-on-insulator (SOI) FinFET technology are studied by technology computer-aided design-based statistical modeling. Compared with planar SOI high-k metal gate CMOS technologies, 14-nm SOI FinFET technology shows better n-to-p tracking mainly due to the strong influence of correlated Fin geometrical variation, as well as reduced uncorrelated variation from an innovative work function process. The impact of the n-to-p tracking characteristics on setup and hold (guard time) of latch circuits is evaluated by corner and Monte Carlo simulation using compact models. It is found that the guard time is significantly modulated by slow/fast and fast/slow corners in certain conditions and, therefore should be considered in guard time design.
Special Section Guest Editorial: Video Analytics for Public Safety (2017)

The <i>Journal of Electronic Imaging</i> (JEI), copublished bimonthly with the Society for Imaging Science and Technology, publishes peer-reviewed papers that cover research and applications in all areas of electronic imaging science and technology.
Nonlinearity enhancement and dispersion management in bismuth microstructured fibers with a filled slot defect (2008)

We investigate nonlinearity enhancement and dispersion management in microstructured fibers with a slotted-defect infiltrated with highly-nonlinear liquid. Using slot-defected-core bismuth microstructured fibers, γ as high as 11,000 W <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−1</sup> km <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−1</sup> and dispersion-flattened characteristics at telecom-band is possible.
Molecular mechanisms in DNA replication and recombination : proceedings of a UCLA Symposium held at Keystone, Colorado, March 27-April 3, 1989 (1990)

Summary of the Conference PART I: Summaries of Workshop Sessions PART II: DNA Structure PART III: DNA Replication PART IV: Initiation of DNA Replication PART V: Multiprotein Replication Systems PART VI: Recombination Mechanisms.
Compact metamaterial antenna array for long term evolution (LTE) handset application (2009)

In the digital world, Moore's Law states the number of transistors on Integrated Circuits (ICs) has been doubling every two years since 1965. While these ICs occupy only 10% of the wireless communication device Moore's Lawarea, the remaining 90%, referred to as RF Front-End Model (FEM), consists of a collection of discrete passive and active components such as antennas, filters, diplexer, duplexers, couplers, power combiner/splitter, and power amplifiers. While these powerful ICs enable effective implementation of multiple input multiple output (MIMO) digital processing, the main issue of MIMO RF FEM implementation in small devices such as handsets still remains unsolved. Without such a full solution, network providers cannot deploy next generation wireless broadband networks, such as 3GPP long term evolution (LTE) networks, that can sustain tens of Mbps throughput with mobility. This paper addresses this specific problem by presenting an LTE MIMO air interface solution for handsets using metamaterial designs, which offer small, low-cost, and low-profile antennas printed directly on PCB for easy integration and simple manufacturing - all critical factors for rapid deployment and commercial success. The proposed metamaterial MIMO array consists of dual resonance antennas occupying lambda <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> /10 times lambda <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> /41 times lambda <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> /387 volume at center frequency 771MHz of the LTE band 746-796MHz. The performances of two antenna array configurations with spacing of lambda <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> /13 and lambda <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> /5 are studied while quantifying its near-filed and far-field channel correlation.
Interlayer Engineering with Different Host Material Properties in Blue Phosphorescent Organic Light-Emitting Diodes (2011)

We investigated the light-emitting performances of blue phosphorescent organic light-emitting diodes, known as PHOLEDs, by incorporating an N,N’-dicarbazolyl-3,5-benzen interlayer between the hole transporting layer and emitting layer (EML). We found that the effects of the introduced interlayer for triplet exciton confinement and hole/electron balance in the EML were exceptionally dependent on the host materials: 9-(4-tert-butylphenyl)-3.6-bis(triphenylsilyl)-9H-carbazole, 9-(4-tert-butylphenyl)-3.6-ditrityl-9H-carbazole, and 4,4’-bis-triphenylsilanyl-biphenyl. When an appropriate interlayer and host material were combined, the peak external quantum efficiency was greatly enhanced by over 21 times from 0.79% to 17.1%. Studies on the recombination zone using a series of host materials were also conducted.