gebhart/patrepeval huggingface dataset:
776: Enhanced Radiosensitivity by Inhibition of the Antiapoptotic Gene Clusterin Using Antisense Oligodeoxynucleotide in a Human Bladder Cancer Model (2005)

You have accessJournal of UrologyDiscussed Poster, Monday, May 23, 2005, 1:00 - 5:00 pm1 Apr 2005776: Enhanced Radiosensitivity by Inhibition of the Antiapoptotic Gene Clusterin Using Antisense Oligodeoxynucleotide in a Human Bladder Cancer Model Kazuki Yamanaka, Hideaki Miyake, Mototsugu Muramaki, Sadao Kamidono, Martin E. Gleave, and Isao Hara Kazuki YamanakaKazuki Yamanaka More articles by this author , Hideaki MiyakeHideaki Miyake More articles by this author , Mototsugu MuramakiMototsugu Muramaki More articles by this author , Sadao KamidonoSadao Kamidono More articles by this author , Martin E. GleaveMartin E. Gleave More articles by this author , and Isao HaraIsao Hara More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)34945-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "776: Enhanced Radiosensitivity by Inhibition of the Antiapoptotic Gene Clusterin Using Antisense Oligodeoxynucleotide in a Human Bladder Cancer Model." The Journal of Urology, 173(4S), pp. 210–211 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 210-211 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Kazuki Yamanaka More articles by this author Hideaki Miyake More articles by this author Mototsugu Muramaki More articles by this author Sadao Kamidono More articles by this author Martin E. Gleave More articles by this author Isao Hara More articles by this author Expand All Advertisement PDF downloadLoading ...
Adiabatic Tip-Plasmon Focusing for Nano-Raman Spectroscopy (2010)

True nanoscale optical spectroscopy requires the efficient delivery of light for a spatially nanoconfined excitation. We utilize adiabatic plasmon focusing to concentrate an optical field into the apex of a scanning probe tip of ∼10 nm in radius. The conical tips with the ability for two-stage optical mode matching of the surface plasmon polariton (SPP) grating-coupling and the adiabatic propagating SPP conversion into a localized SPP at the tip apex represent a special optical antenna concept for far-field transduction into nanoscale excitation. The resulting high nanofocusing efficiency and the spatial separation of the plasmonic grating-coupling element on the tip shaft from the near-field apex probe region allows for true background-free nanospectroscopy. As an application, we demonstrate tip-enhanced Raman spectroscopy (TERS) of surface molecules with enhanced contrast and its extension into the near-IR with 800 nm excitation.
Green synthesis of soluble polyphenol: oxidative polymerization of phenol in water (2007)

Abstract The simple stirring of phenol with an oxidant in water provided a novel green way to synthesize soluble polyphenol. The soluble polyphenol obtained had a high poly(phenylene oxide) unit ratio, poly(phenyleneoxide)/poly(phenylene)=ca. 80/20. Additionally, the insoluble fraction was identified as a poly(phenyleneoxide), which has a crosslinking point for every 5.5×103 molecular weight. These results suggest that oxidative polymerization in water can be run in a manner to control the coupling selectivity of phenol. Both the soluble polyphenol and the insoluble fraction showed a high thermal stability. Oxidative polymerization in water provides the potential for a formaldehyde-free and regioselected soluble poly(phenyleneoxide) from phenol.
ChemInform Abstract: Enzymes in Organic Synthesis. Part 42. Investigation of the Effects of the Isozymal Composition of Pig Liver Esterase on Its Stereoselectivity in Preparative‐Scale Ester Hydrolyses of Asymmetric Synthetic Value. (1988)

Abstract Commercially available pig liver esterase (PLE) is separated in 6 different main isozyme fractions and it is shown that their individual stereospecifities are essentially the same in the hydrolysis of representative monocyclic and acyclic diester substrates (I), (III) (→ (II), (IV)).
Improved Durability to SARS-CoV-2 Vaccine Immunity following Coimmunization with Molecular Adjuvant Adenosine Deaminase-1 (2022)

Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines have demonstrated strong immunogenicity and protection against severe disease, concerns about the duration and breadth of these responses remain. In this study, we show that codelivery of plasmid-encoded adenosine deaminase-1 (pADA) with SARS-CoV-2 spike glycoprotein DNA enhances immune memory and durability in vivo. Coimmunized mice displayed increased spike-specific IgG of higher affinity and neutralizing capacity as compared with plasmid-encoded spike-only-immunized animals. Importantly, pADA significantly improved the longevity of these enhanced responses in vivo. This coincided with durable increases in frequencies of plasmablasts, receptor-binding domain-specific memory B cells, and SARS-CoV-2-specific T follicular helper cells. Increased spike-specific T cell polyfunctionality was also observed. Notably, animals coimmunized with pADA had significantly reduced viral loads compared with their nonadjuvanted counterparts in a SARS-CoV-2 infection model. These data suggest that pADA enhances immune memory and durability and supports further translational studies.
Low-Resistivity Long-Length Horizontal Carbon Nanotube Bundles for Interconnect Applications—Part II: Characterization (2013)

Due to the enormous challenges of fabricating long horizontally aligned carbon nanotube (HACNT) bundle interconnects, there exists little research on characterization of long HACNT interconnects. In this paper, taking advantage of our unique HACNT fabrication process outlined in the companion paper, the electrical and self-heating characterization of long HACNT bundles are reported. Negative temperature coefficients of resistance for both per unit length resistance and metal-CNT contact resistance are confirmed from measurements. This first report on the electrical and thermal characterization fills the wide gap between CNT interconnect modeling efforts and corresponding experimental efforts by providing many important extracted parameters that are critical in various modeling and analyses.
Nonlinear wave propagation in horns and ducts (1995)

The one-parameter sound field of finite amplitude is modeled by an acoustic transmission line model and by block-oriented system models containing dynamic linear and static nonlinear subsystems. The transmission line model is based on conical elements and each element is represented by a linear four-port and a nonlinear source of volume velocity derived from the nonlinear wave equation in Lagrangian coordinates. The block-oriented system model with a lattice structure shows the forward and backward propagating sound-pressure waves separately. A simplified overall model and the derived higher-order system functions based on the Volterra approach describe the relation between the sound pressure at two points in the sound field. The presented models are the basis for numerical simulations, nonlinear system identification, and signal processing related to the nonlinear sound propagation in horns, ducts, and other acoustical systems with a nearly one-parameter sound field.
ChemInform Abstract: A TUNGSTEN T‐SHAPED METHYLENE COMPLEX AND RELATED METHYLIDYNE HYDRIDE COMPLEXES (1981)

Abstract Die Protonierung des Methylidin‐ Komplexes (II) mit CF 3 SO 3 H oder seinem Trimethylphosphoniumsalz liefert den kristallinen Methylenkomplex (I), der ein Temp.‐abhängiges 1 H‐NMR‐Spektrum hat, dessen Änderungen mit der starken Verzerrung des Methylenliganden und dem Austausch der Methylen‐H‐Atome über ein symm. Zwischenprodukt erklärt werden.
State-of-the-art continuous-wave InGaN laser diodes in the violet, blue, and green wavelength regimes (2010)

We present state-of-the-art performance from green, blue, and violet InGaN-based laser diodes fabricated on nonpolar and semipolar GaN substrates. Using these novel crystal orientations, we demonstrate high power, high efficiency, continuous-wave operation from single-lateral-mode electrically pumped laser diodes at wavelengths from 405 nm to 500 nm. Additionally, we present the longest reported continuous-wave lasing demonstration of 525 nm and an output power of over 9 mW at 521 nm. Wall-plug efficiencies of over 25% in the violet region, 17.5% in the blue region, over 5% at 472nm, and 2.2% in the 500 nm range are reported. These InGaN-based devices offer dramatic improvement in size, weight, and cost over conventional gas and solid state lasers and may enable a variety of new applications in defense and security.
Alkin‐Koordination an Organorheniumoxide mit Rhenium in hohen Oxidationsstufen (1988)

Als ausgezeichnetes Edukt für die Synthese von Rheniumkomplexen mit π‐Alkin‐Liganden erwies sich Methylrhenium(VII)‐oxid 1 . Wie unten skizziert, läßt sich die sauerstoffabstrahierende Wirkung von polymergebundenem Triphenylphosphan P zur Gewinnung der neuen Komplexe 2 nutzen. Nach theoretischen Arbeiten war die Existenz solcher Re v ‐Verbindungen recht unwahrscheinlich. Reduktion von 2 , R = R′ = Me, führt zum ersten Re IV ‐Alkin‐Komplex 3 . magnified image
Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions (2021)

Mechanisms underlying severe coronavirus disease 2019 (COVID-19) disease remain poorly understood. We analyze several thousand plasma proteins longitudinally in 306 COVID-19 patients and 78 symptomatic controls, uncovering immune and non-immune proteins linked to COVID-19. Deconvolution of our plasma proteome data using published scRNA-seq datasets reveals contributions from circulating immune and tissue cells. Sixteen percent of patients display reduced inflammation yet comparably poor outcomes. Comparison of patients who died to severely ill survivors identifies dynamic immune-cell-derived and tissue-associated proteins associated with survival, including exocrine pancreatic proteases. Using derived tissue-specific and cell-type-specific intracellular death signatures, cellular angiotensin-converting enzyme 2 (ACE2) expression, and our data, we infer whether organ damage resulted from direct or indirect effects of infection. We propose a model in which interactions among myeloid, epithelial, and T cells drive tissue damage. These datasets provide important insights and a rich resource for analysis of mechanisms of severe COVID-19 disease.
Stray-field NMR diffusion q -space diffraction imaging of monodisperse coarsening foams (2016)

The technique of stray field diffusion NMR is adapted to study the diffusion properties of water in monodisperse wet foams. We show for the first time, that the technique is capable of observing q-space diffusion diffraction peaks in monodisperse aqueous foams with initial bubble sizes in the range of 50-85μm. The position of the peak maximum can be correlated simply to the bubble size in the foam leading to a technique that can investigate the stability of the foam over time. The diffusion technique, together with supplementary spin-spin relaxation analysis of the diffusion data is used to follow the stability and coarsening behaviour of monodisperse foams with a water fraction range between 0.24 and 0.33. The monodisperse foams remain stable for a period of hours in terms of the initial bubble size. The duration of this stable period correlates to the initial size of the bubbles. Eventually the bubbles begin to coarsen and this is observed in changes in the position of the diffusion diffraction maxima.
Reduced expression of CD9 in oral squamous cell carcinoma: CD9 expression inversely related to high prevalence of lymph node metastasis (2001)

Because CD9 is implicated in cell growth, cell adhesion and cell motility, altered CD9 expression might be involved in cancer invasion and metastasis. We have studied the immunolocalization of CD9 in oral squamous cell carcinoma (SCC). Sections prepared from paraffin-embedded specimens from patients with SCC of the oral cavity were stained with a monoclonal anti-CD9 antibody by means of the streptoavidin biotin method. Significant reduction or complete loss of CD9 expression was observed in cancer cells at the periphery of the cancer nests in the advancing front of invading tumor. Among 78 cases of oral SCCs examined, 46 (59.0%) cases were completely negative for CD9 expression. Loss of CD9 expression in cancer tissue strongly correlated with a high incidence of cervical lymph node metastasis and poorer prognosis (P=0.001). Thus a close examination of CD9 in SCC tissue would be useful for the prognosis of patients with oral carcinoma.
RELATIONSHIP OF RHINOVIRUS INFECTION TO MILD UPPER RESPIRATORY DISEASE (1966)

Journal Article RELATIONSHIP OF RHINOVIRUS INFECTION TO MILD UPPER RESPIRATORY DISEASE: III. FURTHER EPIDEMIOLOGIC OBSERVATIONS IN MILITARY PERSONNEL Get access M. A. MUFSON, M. A. MUFSON Search for other works by this author on: Oxford Academic PubMed Google Scholar H. H. BLOOM, H. H. BLOOM Search for other works by this author on: Oxford Academic PubMed Google Scholar B. R. FORSYTH, B. R. FORSYTH Search for other works by this author on: Oxford Academic PubMed Google Scholar R. M. CHANOCK R. M. CHANOCK 3 3Send reprint requests to Dr. Robert Chanock, National Institutes of Health Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Epidemiology, Volume 83, Issue 3, May 1966, Pages 379–388, https://doi.org/10.1093/oxfordjournals.aje.a120593 Published: 01 May 1966 Article history Received: 28 July 1965 Published: 01 May 1966
Intracellular single-chain antibody inhibits integrin VLA-4 maturation and function (1996)

A single-chain antibody construct was prepared containing the VH and VL regions of anti-(integrin alpha 4) antibody HP1/2, an interchain linker and a KDEL endoplasmic reticulum retention sequence. Intracellular expression of this single-chain antibody caused cell-surface expression of alpha 4 beta 1 integrin to be decreased by 80% on selected RD cells and by 65-100% on selected Jurkat cells, relative to mock transfectants. Immunoprecipitation from single-chain-antibody-transfected cells showed that the single-chain antibody was complexed with the integrin alpha 4 and beta 1 subunits, and the diminished sizes of alpha 4 and beta 1 were consistent with impaired maturation. Furthermore, cell adhesion to alpha 4 beta 1 ligands [VCAM-1 (vascular cell adhesion molecule-1), FN40 (40 kDa chymotryptic fragment of fibronectin) and CS1] was greatly impaired in both RD and Jurkat cells, and cell spreading on immobilized FN40 protein was almost completely eliminated. Thus we conclude that intracellular single-chain antibodies may be used to reduce or eliminate cell-surface expression of a specific integrin, with specific functional consequences. This approach should be generally applicable to other integrin subunits.
ChemInform Abstract: Asymmetric Thermal Reactions with Oppolzer′s Camphor Sultam (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
HPC Cloud for Scientific and Business Applications (2018)

High performance computing (HPC) clouds are becoming an alternative to on-premise clusters for executing scientific applications and business analytics services. Most research efforts in HPC cloud aim to understand the cost benefit of moving resource-intensive applications from on-premise environments to public cloud platforms. Industry trends show that hybrid environments are the natural path to get the best of the on-premise and cloud resources—steady (and sensitive) workloads can run on on-premise resources and peak demand can leverage remote resources in a pay-as-you-go manner. Nevertheless, there are plenty of questions to be answered in HPC cloud, which range from how to extract the best performance of an unknown underlying platform to what services are essential to make its usage easier. Moreover, the discussion on the right pricing and contractual models to fit small and large users is relevant for the sustainability of HPC clouds. This article brings a survey and taxonomy of efforts in HPC cloud and a vision on what we believe is ahead of us, including a set of research challenges that, once tackled, can help advance businesses and scientific discoveries. This becomes particularly relevant due to the fast increasing wave of new HPC applications coming from big data and artificial intelligence.
Tailored deformation behavior of 304L stainless steel through control of the crystallographic texture with laser-powder bed fusion (2022)

Laser-powder bed fusion (L-PBF) has gained significant research interest, not only for its profound advantage of producing near-net shape complex geometries of metallic parts, but also for the possibility of producing tailored microstructures. Here we exploit the capability of manipulating the crystallographic texture by L-PBF to tailor the deformation behavior of austenitic stainless steels. In specific, by adjusting the laser power and the laser scanning speed, tailored crystallographic textures can be obtained, along the uniaxial loading direction in 304L stainless steel samples produced by L-PBF. In situ neutron diffraction and uniaxial tension and compression tests are undertaken to investigate the extent of the transformation induced plasticity effect and to correlate it with the tailored macrostructures. The influence of the initial and the evolving crystallographic texture on the deformation behavior is demonstrated and elaborated accordingly. The observed asymmetry in the deformation behavior between tension and compression is also discussed in detail.
Design of a Non-Linear Sized I/Q Digital PA for 5G mm-Wave Communications in 28 nm CMOS (2020)

This paper presents the design of a DPA for 5G telecommunications applications in TSMC (Taiwan Semiconductor Manufacturing Company) 28 nm CMOS. A modified Gilbert cell is proposed to perform the function of amplification and reversing the phase within a compact layout, improving the efficiency. To overcome the linearity issue of DPAs, a non-linear sizing technique of the PA cells is employed. The effective widths of relative bit cells need to be increased to conform to non-linear sizing thus providing linearity with acceptable INL (Integral Non-Linearity)and DNL (Differential Non-Linearity) results. The simulated saturated output power is 11.7 dBm with power added efficiency at 13 percent with the device working off a carrier frequency of 28 GHz.
Regime of a wideband phase-amplitude modulation in a CW magnetron transmitter with a phase control (2014)

A model of the CW high-power transmitter, utilizing frequency-locked magnetrons with a phase control studied initially as a prototype of controllable in phase and power an RF source for intensity-frontier superconducting linacs, was considered for telecommunication as a model of magnetron source, acceptable for a wideband phase-amplitude modulation at a precisely stable carrier frequency. The R&amp;D conducted with CW, 2.45 GHz, 1 kW, microwave oven magnetrons demonstrated that the frequency locking of the magnetrons by the phase-modulated signal provides wideband phase and amplitude modulation at the modulating frequency at least up to 3 MHz and large magnitude, keeping the carrier frequency precisely stable, without broadening of the spectral line width. Performed experiments with power combining verified applicability of the transmitter based on the frequency-locked magnetrons for wideband phase and amplitude modulation, which may be used for telecommunication. Results of the experiments are described in the presented work.
Impact of Lifestyle Behaviors on Postprandial Hyperglycemia during Continuous Glucose Monitoring in Adult Males with Overweight/Obesity but without Diabetes (2021)

Data regarding hyperglycemia-related factors were scarce in people without diabetes. Fifty males (age 50-65 years) with overweight/obesity but without diagnosis of diabetes were recruited. After excluding participants with the 2 h plasma glucose value during a 75 g oral glucose tolerance test ≥200 mg/dL, continuous glucose monitoring (CGM) was performed for 6 days. Subjects with ≥1800 CGM readings were included (<i>n</i> = 36). The CGM indices of hyperglycemia were significantly associated with disposition index and snacking frequency. In receiver-operating characteristic analysis for predicting the maximal CGM glucose ≥200 mg/dL, the area under curves of disposition index, snacking frequency, and minimal daily step counts during the study were 0.69, 0.63, and 0.68, whereas the cutoff values were 1.57, once daily, and 2499 steps, respectively. After adjustments, the lower disposition index (≤1.57), higher snacking frequency (≥1 per day), and lower minimal step (≤2499 steps per day) categories conferred 14.5, 14.5, and 6.6-fold increased probabilities for having the maximum level ≥ 200 mg/dL, respectively. In addition, the snacking habits were significantly associated with insulin resistance and compensatory hyperinsulinemia. In conclusion, in middle aged males with overweight/obesity but without diabetes, snacking and physical inactivity serve as the major drivers of postprandial hyperglycemia independently of β-cell function.
Non‐Cell‐Adhesive Substrates for Printing of Arrayed Biomaterials (2014)

Cellular microarrays have become extremely useful in expediting the investigation of large libraries of (bio)materials for both in vitro and in vivo biomedical applications. An exceedingly simple strategy is developed for the fabrication of non-cell-adhesive substrates supporting the immobilization of diverse (bio)material features, including both monomeric and polymeric adhesion molecules (e.g., RGD and polylysine), hydrogels, and polymers.
Message Fragmentation for Disrupted Links (2011)

Abstract—In networks with unstable links the connection between the sender and the receiver may be cut before the entire message has been transmitted. Quantization of the message into blocks before its transmission, enables message fragments consisting of one or more such blocks to be transmitted successfully, even if the connection time is too short for transmitting the entire message. But fragmentation may also reduce the chances of delivering the entire message to its destination, due to lost or misrouted fragments. In this paper we (1) formulate the problem of in-time transmission of fragmented messages in disrupted networks; and (2) develop methods to analytically estimate the mean transmission time of fragmented message within a basic system model for the case of transmission over a single disrupted link. I.