gebhart/patrepeval huggingface dataset:
Structure of human immunodeficiency virus type 1 Vpr(34–51) peptide in micelle containing aqueous solution (2002)

Human immunodeficiency virus type 1 protein R (HIV-1 Vpr) promotes nuclear entry of viral nucleic acids in nondividing cells, causes G(2) cell cycle arrest and is involved in cellular differentiation and cell death. Vpr subcellular localization is as variable as its functions. It is known, that consistent with its role in nuclear transport, Vpr localizes to the nuclear envelope of human cells. Further, a reported ion channel activity of Vpr is clearly dependent on its localization in or at membranes. We focused our structural studies on the secondary structure of a peptide consisting of residues 34-51 of HIV-1 Vpr. This part of Vpr plays an important role in Vpr oligomerization, contributes to cell cycle arrest activity, and is essential for virion incorporation and binding to HHR23A, a protein involved in DNA repair. Employing NMR spectroscopy we found this part of Vpr to be almost completely alpha helical in the presence of micelles, as well as in trifluoroethanol containing and methanol/chloroform solvent. Our results provide structural data suggesting residues 34-51 of Vpr to contain an amphipathic, leucine-zipper-like alpha helix, which serves as a basis for oligomerization of Vpr and its interactions with cellular and viral factors involved in subcellular localization and virion incorporation of Vpr.
Load balancing with JET (2021)

Hash-based stateful load-balancers employ connection tracking to avoid per-connection-consistency (PCC) violations that lead to broken connections. In this paper, we propose Just Enough Tracking (JET), a new algorithmic framework that significantly reduces the size of the connection tracking tables for hash-based stateful load-balancers without increasing PCC violations.
Nonideal rotations in nuclear magnetic resonance: Estimation of coherence transfer leakage (2000)

When spherical tensors are rotated by certain angles, coherence transfer selection rules may apply. For example, a π rotation cleanly inverts the coherence order. A π/2 rotation of a T01 tensor creates only T±11 tensors. In this work estimations are given for the coherence transfer leakage under the action of rotations with small errors in the rotation angle or axis. Although the theory is stated with particular applications to NMR (nuclear magnetic resonance) in mind it is equally applicable wherever nonideal rotations of spherical tensors are considered (e.g., quantum computing and relaxation theory). In NMR it is useful for the estimation of coherence transfer leakage, especially in pulse sequences with many nπ pulses. The results are also applicable to spinors and half-integer representations of the rotation group.
Simulation of Sand Arching Mechanics Using an Elasto-Plastic Finite Element Formulation (1994)

SUMMARY This work is a simulation of sand production mechanics using an elasto-plastic finite element formulation. An open vertical well was considered in order to simulate the performance of near-wellbore unconsolidated sand during hydrocarbon production. In the simulation procedure, the assigned values of the initial stress field around the wellbore were taken from previous sand arching experiments conducted at the Colorado School of Mines on a similar well configuration using 20/40 frac sand. The mechanical rock properties used in simulation were also taken from previous experimental work. The model did not require fluid properties such as density and viscosity be determined. The values of cohesion and pressure drop across the open well sandface were varied in the simulation of hydrocarbon production through the considered wellbore. Through multiple simulations, the effect of these variations on the stability of the sand surrounding the wellbore was observed. In this study, stability is considered to be elastic behavior and plastic behavior is assumed to indicate failure. It is concluded that sand production from a well can be modeled using the elasto-plastic finite element formulation. The stability of the sand around the wellbore depends on the pressure-drop across the sand face and the cohesion of the sand grains. The model presented can provide information on whether a producing zone will exhibit sand production problems.
Skin cancers in Croatia, 2003-2005: epidemiological study. (2010)

This study presents the incidence of major nonmelanoma skin cancers (major NMSCs), other nonmelanoma skin cancers (other NMSCs) and malignant melanoma (MM) in Croatia. The skin cancers recorded between 1 January 2003 and 31 December 2005 were retrospectively analyzed. Until 2003, the incidence of major NMSCs and other NMSCs was not estimated in Croatia. Incident cases of NMSCs were identified by the use of a questionnaire distributed to dermatology departments in Croatia and then collected at the University Department of Dermatology and Venereology, Zagreb University Hospital Center, and from the records kept at the National Cancer Registry. Incident cases of MM were extracted from the National Cancer Registry. During the 3-year period, 9,479 cases of major NMSCs are recorded, 4,622 (49%) in male and 4,857 (51%) in female patients. The crude incidence rate was 72.1/100,000 for males and 70.3/100,000 for females. Basal cell carcinoma (BCC) was the most common major NMSC in both sexes. In the total number of major NMSCs, there were 7,244 cases of BCC. Squamous cell carcinoma (SCC) was the second most common major NMSC. There were 1,860 SCC cases. The crude incidence rate was 54.9/100,000 for BCC in males, 53.9/100,000 in females, and 14.6/100,000 for SCC in male and 13.4/100,000 in female patients. Other NMSCs were registered in 119 cases (53% male and 47% female). The crude incidence rate was 0.9/100,000 for male and 0.8/100,000 for female patients. MM was registered in 1,427 cases (48% male and 52% female.) The crude incidence rate was 10.7/100,000 for males and females. These results will serve as reference for studying the patterns of descriptive epidemiology of major NMSCs, other NMSCs and MM in Croatia and Europe in the forthcoming years.
ChemInform Abstract: TRANSITION METAL‐METHYLENE COMPLEXES. XXIV. CARBENE ADDITION TO A COBALT‐COBALT DOUBLE BOND (1981)

Abstract Der zweikernige, formal eine Metall‐Metall‐DoppeIbindung aufweisende Cobalt‐Komplex (I) reagiert mit den Diazoalkanen (II) im Temperaturbereich ‐40OC bis +25°C unter Stickstoff‐Eliminierung und Komplexierung der jeweiligen Carben‐Bausteine als Brückenliganden zu den [DimetallacyclopropanHrmethylen‐Derivaten (III), (IV) bzw. (V).
Crystal Structure Analysis of Recombinant Human Uteroglobin and Molecular Modeling of Ligand Binding (2000)

Uteroglobin, a steroid-inducible, cytokine-like, secreted protein with immunomodulatory properties, has been reported to bind progesterone, polychlorinated biphenyls (PCB), and retinol. Structural studies may delineate whether binding of ligands is a likely physiological function of human uteroglobin (hUG). We report a refined crystal structure of uncomplexed recombinant hUG (rhUG) at 2.5-A resolution and the results of our molecular modeling studies of ligand binding to the central hydrophobic cavity of rhUG. The crystal structure of rhUG is very similar to that of reported crystal structures of uteroglobins. Using molecular modeling techniques, the three ligands--PCB, progesterone, and retinol--were docked into the hydrophobic cavity of the dimer structure of rhUG. We undocked the progesterone ligand by pulling the ligand from the cavity into the solvent. From our modeling and undocking studies of progesterone, it is clear that these types of hydrophobic ligands could slip into the cavity between helix-3 and helix-3' of the dimer instead of between helix-1 and helix-4 of the monomer, as proposed earlier. Our results suggest that at least one of the physiological functions of UG is to bind to hydrophobic ligands, such as progesterone and retinol.
DNN Based Speaker Embedding Using Content Information for Text-Dependent Speaker Verification (2018)

In this paper, we are interested in exploring Deep Neural Network (DNN) based speaker embedding for Random-digit task using content information. To this end, a technique is applied to automatically select common phonetic units between the enrollment and test data to produce speaker verification scores. Furthermore, a novel approach is proposed to incorporate content information in the DNN directly. It is hypothesized that features extracted using this DNN will be helpful for the task. Experiments on the RSR dataset show that the proposed method outperforms the baseline i-vector system by 43% relative equal error rate.
A tipping pulse scheme for an rf-SQUID qubit (2001)

We present a technique of using a stream of single flux quantum (SFQ) pulses magnetically coupled to the qubit junction to control the state of a rf-SQUID qubit. This momentarily suppresses the critical current of the junction and lowers the potential barrier so the tunneling oscillation frequency is increased.
Transesterification Catalyzed by Ionic Liquids on Superhydrophobic Mesoporous Polymers: Heterogeneous Catalysts That Are Faster than Homogeneous Catalysts (2012)

Homogeneous catalysts usually show higher catalytic activities than heterogeneous catalysts because of their high dispersion of catalytically active sites. We demonstrate here that heterogeneous catalysts of ionic liquids functionalized on superhydrophobic mesoporous polymers exhibit much higher activities in transesterification to form biodiesel than homogeneous catalysts of the ionic liquids themselves. This phenomenon is strongly related to the unique features of high enrichment and good miscibility of the superhydrophobic mesoporous polymers for the reactants. These features should allow the design and development of a wide variety of catalysts for the conversion of organic compounds.
EVALUATION OF ROADSIDE SAFETY DEVICES USING FINITE ELEMENT ANALYSIS (2004)

In recent years, roadside safety research efforts have focused on the utilization of computer simulation technology to gain a better understanding of the behavior of roadside safety devices when subjected to vehicular impact. The objective of this project was to utilize the resources of the Center for Transportation Computational Mechanics to support the Texas Department of Transportation (TxDOT) roadside safety research. The selection of roadside safety features to be modeled and simulated under this project was made in consultation with TxDOT personnel. Priority was given to modeling systems in support of ongoing, TxDOT-sponsored roadside safety projects. When design problems were identified through simulation or crash testing, researchers examined various design modifications to address the deficiencies and improve impact performance of the system. The results of the simulations were used to develop recommended improvements for full-scale crash testing and potential implementation. Three distinct roadside safety issues were investigated with the aid of computer simulation. An alternative to the popular T6 tubular W-beam bridge rail was developed to address problems with vehicle instability observed in full-scale crash testing. A retrofit connection to TxDOT's grid-slot portable concrete barrier was developed to limit dynamic barrier deflections to levels more practical for work zone deployment. Finally, crashworthy mow strip configurations were developed for use when vegetation control around guard fence systems is desired to reduce the cost and risk associated with hand mowing.
Tick-borne pathogens detection in Caribbean ticks using high-throughput microfluidic real-time PCR (DOMOTICK Project). [C5] (2017)

Among hematophagous arthropods, ticks transmit the greater variety of pathogens of public health and veterinary importance whose (re)-emergence is recognized worldwide. Whereas the main human and animal tick-borne pathogens are well characterised in the Northern hemisphere, very few is known concerning the diversity of tick species and tick-borne pathogens circulating within the Neotropical zone of the Americas, especially concerning the Caribbean area. Most of the epidemiological data on the topic are based on old records and focused on the main livestock pathogens such as Ehrlichia ruminantium, Babesia (bovis and bigemina) and Anaplasma marginale. These observations underline the need to develop high throughput diagnosis methods that will allow us to conduct large scale epidemiological surveys required to better anticipate the risk of (re)-emergence of tick-borne disease in such areas. In this context, the DOMOTICK project was designed to develop a new high-throughput real-time PCR method for a large scale screening of tick-borne pathogens potentially circulating in the Caribbean. This technology is based on high-throughput microfluidic real-time PCRs using Taqman probes (BioMarkTM dynamic arrays, Fluidigm Corporation), allowing the simultaneous detection of up to 95 pathogens across 95 samples of ticks (Michelet et al, 2014). The choice of pathogens included in this new high-throughput technology was based on a comprehensive analysis of the literature, and on a without a priori detection of new or unsuspected pathogens by RNA-sequencing on nucleic acids extracted from ticks collected in Guadeloupe and Martinique. NGS analysis suggests that these ticks may harbour more pathogenic microorganisms than the currently monitored in the Caribbean, such as Rickettsia and Borrelia species of public health importance. Up to now, 40 bacterial species have been listed, including the genera Anaplasma, Ehrlichia, Bartonella, Borrelia, Rickettsia, Mycoplasma, Francisella, Coxiella, Aegyptianella ; 14 parasites species, belonging to the genera Babesia, Theleria, Hepatozoon, Leishmania, Rangelia vitalii, Cytauxzoon felis ; and 32 arboviruses mainly belonging to viral genus of Orthobunyavirus, Phlebovirus, Nairovirus, Asfivivirus, Thogotovirus, Flavivirus, Coltivirus and Orbivirus. The high-throughput real-time PCR technology developed here have been validated on tick samples collected in Guadeloupe and Martinique. Finally, this new high throughput method will allow exploratory epidemiological studies on tick-borne pathogens circulating within Caribbean ticks collected on various vertebrate hosts through some Caribbean islands, such as Trinidad and Tobago, St Kitts, Barbados, St Lucia, and Cuba, thanks to the CaribVet network, and to local veterinarians.
Design of a Wireless, Passive, Single-Use Emergency Call System (2010)

In order to improve patient access to nurses during emergencies, a wireless wrist-mounted call button system was developed. The goal of this project was to create a simple, easy-to-use system that features a completely passive, wireless call button. Three major problems in existing systems — inability for patients to locate or reach the button, unnecessary user interface complexity, and the introduction of a potential vector for hospital-contracted illness — were addressed in the design. The wireless nature of the device ensures that it is always near the patient. A single-button interface considerably simplifies its use in comparison to multi-button systems, eliminating the possibility of incorrect button presses. Finally, the proposed call button uses inexpensive technologies and can be manufactured for such a low cost that it can be offered as a single-use device, eliminating the possibility of patient-to-patient disease transmission. Using radio-frequency identification (RFID) technology, patients are able to call for hospital staff from any location in the hospital that is covered by readers. The call button uses a passive RFID tag that can be turned on or off by a mechanical switch. A second tag is used to notify the system when a patient is out of range. The design was prototyped and tested, and future improvements are suggested.
An Optimal Training Signal Structure for Frequency-Offset Estimation (2005)

This paper addresses an optimal training-signal design for frequency-offset estimation. Based on minimizing the Cramer-Rao lower bound for frequency-offset estimation with constraints on the peak and the total training signal energies, and the training block length, the optimal training-signal structure is developed. An approximate version of the optimal training-signal structure is proposed, which has practically the same performance as the optimal one, and provides convenience in training-signal generation and estimator derivation. Two robust reduced-complexity frequency-offset estimation methods for the proposed training structures are presented. In order to handle larger frequency offsets, modified training-signal structures are proposed. Frequency-offset estimation methods suitable for these training signals are also derived, based on the best linear unbiased estimation principle. Analytical and simulation results show that the proposed training-signal structures improve the estimation performance significantly.
Analysis of the Normalized Sign-Sign LMS Algorithm (2021)

This work repots results of the convergence analysis of the normalized sign-sign least mean square (NSSLMS) algorithm when the input is real-valued data. The results includes expressions for different parameters, such as the steady-state mean-square error, and the tracking mean-square error. Moreover, the performance of the normalized sign-sign LMS algorithm is compared with that of the sign-sign LMS algorithm. The convergence behavior includes the rate of convergence. Finally, simulation results suggest that the normalized sign-sign LMS algorithm can be used as a good replacement for the sign-sign LMS algorithm as the former algorithm offers comparatively much faster rate of convergence than the latter algorithm.
Fast segmentation of the JPEG compressed documents (1998)

The <i>Journal of Electronic Imaging</i> (JEI), copublished bimonthly with the Society for Imaging Science and Technology, publishes peer-reviewed papers that cover research and applications in all areas of electronic imaging science and technology.
Phyllanthusmin Derivatives Induce Apoptosis and Reduce Tumor Burden in High-Grade Serous Ovarian Cancer by Late-Stage Autophagy Inhibition (2018)

High-grade serous ovarian cancer (HGSOC) is a lethal gynecological malignancy with a need for new therapeutics. Many of the most widely used chemotherapeutic drugs are derived from natural products or their semi-synthetic derivatives. We have developed potent synthetic analogues of a class of compounds known as phyllanthusmins, inspired by natural products isolated from <i>Phyllanthus poilanei</i> Beille. The most potent analogue, PHY34, had the highest potency in HGSOC cell lines <i>in vitro</i> and displayed cytotoxic activity through activation of apoptosis. PHY34 exerts its cytotoxic effects by inhibiting autophagy at a late stage in the pathway, involving the disruption of lysosomal function. The autophagy activator, rapamycin, combined with PHY34 eliminated apoptosis, suggesting that autophagy inhibition may be required for apoptosis. PHY34 was readily bioavailable through intraperitoneal administration <i>in vivo</i> where it significantly inhibited the growth of cancer cell lines in hollow fibers, as well as reduced tumor burden in a xenograft model. We demonstrate that PHY34 acts as a late-stage autophagy inhibitor with nanomolar potency and significant antitumor efficacy as a single agent against HGSOC <i>in vivo</i> This class of compounds holds promise as a potential, novel chemotherapeutic and demonstrates the effectiveness of targeting the autophagic pathway as a viable strategy for combating ovarian cancer. <i>Mol Cancer Ther; 17(10); 2123-35. ©2018 AACR</i>.
PCEP enhances IgA mucosal immune responses in mice following different immunization routes with influenza virus antigens (2010)

We conclude that PCEP is a potent and versatile mucosal adjuvant that can be administered in a variety of routes and effectively enhances systemic and local immune responses. Furthermore, intranasal immunization was found to be the best administration route for enhancing IgA titers, providing further evidence for the potential of PCEP as a mucosal adjuvant.
Comparing and integrating solar forecasting techniques (2016)

The SunCast Solar Power Forecasting System is comprised of various models to predict the short term solar resource from 15 min through 168 hours. It leverages surface and satellite observations in building both physically-based as well as artificial intelligence nowcasting models. It also employs numerical weather prediction models, including an enhanced version of the Weather Research and Forecasting model, WRF-Solar. This paper compares the various techniques and describes how they are integrated to provide a seamless probabilistic power forecast.
Monitoring of haemodynamic performance in complex pacing systems with a microchip pacer patient card (2001)

The morphology of the ventricular evoked response (VER) changes significantly during adrenergic stimulation and during increase of the stimulated heart rote. We studied, if the VER, which results from the heart's electrical reaction to every, effective ventricular pacing impuls, can be used to drive stimulation rate for rate adptive pacing. The variation in amplitude of two points of the VER were used as a sensor parameter. These two points, called Spoint and T-point, are individually located and must be determined during a calibration procedure. The S-point is placed at the beginning of the horizonlal plateau phase, the T-point is set just before the maximum amplitude of the VER. During stimulation the signal amplitude at the S-point and at the T-poim rises simultaneously. Under effort the increase of the signal amplitude at the Spoint is less as compared to that at the T-point. For rate adapdon, a differenceparameter is used: it is calculated as the difference bep.veen the signal amplitude at the T-point and the signal amplitude at the S-point. The resulting parameter is independent of rate effect, but strongly rises with load increase. Our study population consisted of 12 patients (6 female, 6 male, a mean age of 67 + 14 years) with chronically implanted dual-chamber pacemakers (Logns, Biotronic Inc., Berlin, Germany). All patients were ehronotmpic incompetent. The first part of the study comprised the development of the pacing algorithm. The patients were stressed by bicycle ergnmetry and the continously telemetrically recorded VER was transmitted to an external device and analyzed. During the second part the patients were stressed using in the same pmlocoll. The measured VER signals were transmitted to a recording and analyzing devize (Unilyzer, Biotonic Inc.) which determined the necessary pacing rate in accordance v,'ith the developed algorithm. Conclusion: It could be demonstrated that an algorithm using the VER as a sensor signal allows load edaequate rote adaption in continously paced patients. The resulting parameter is independent of rote effect, but strongly rises with load increase.
Romano (2012)

Workload consolidation is a key technique in reducing costs in virtualized datacenters. When considering storage consolidation, a key problem is the unpredictable performance behavior of consolidated workloads on a given storage system. In practice, this often forces system administrators to grossly overprovision storage to meet application demands. In this paper, we show that existing modeling techniques are inaccurate and ineffective in the face of heterogenous devices. We introduce Romano, a storage performance management system designed to optimize truly heterogeneous virtualized datacenters. At its core, Romano constructs and adapts approximate workload-specific performance models of storage devices automatically, along with prediction intervals. It then applies these models to allow highly efficient IO load balancing.