gebhart/patrepeval huggingface dataset:
Recent Advances in PDE4 Inhibitors as Immunoregulators and Anti- Inflammatory Drugs (2002)

The phosphodiesterases (PDEs) are responsible for the hydrolysis of intracellular cyclic adenosine and guanosine monophosphate (cAMP and cGMP, respectively). They are classified into 11 major families (PDE1-11) and the type 4 phosphodiesterase (PDE4) is a cAMP-specific enzyme localized in airway smooth muscle cells as well as in immune and inflammatory cells. The PDE4 activity is associated with a wide variety of diseases some of which have been related to an inflammatory state, (e.g. asthma, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis (RA)) while others have recently been connected to autoimmune pathology. Therefore, an intense effort toward the development of PDE4 inhibitors has been generated for the last decade. Unfortunately, the effects of prototype PDE4 inhibitors have been compromised by side effects such as nausea and emesis and the clinical use of those compounds is still limited. Several companies have focused on the design of a new generation of PDE4 inhibitors dissociating beneficial activity and adverse effects. This review highlights the recent data of the most advanced clinical candidates, the design and structure activity relationships of the recent structural series reported in the literature over the last two years, as well as recent advances in the multiple therapeutic indications of PDE4 inhibitors (a review with 375 references).
Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase–thioesterase enzyme pair (2016)

Halogenated pyrroles (halopyrroles) are common chemical moieties found in bioactive bacterial natural products. The halopyrrole moieties of mono- and dihalopyrrole-containing compounds arise from a conserved mechanism in which a proline-derived pyrrolyl group bound to a carrier protein is first halogenated and then elaborated by peptidic or polyketide extensions. This paradigm is broken during the marine pseudoalteromonad bacterial biosynthesis of the coral larval settlement cue tetrabromopyrrole (1), which arises from the substitution of the proline-derived carboxylate by a bromine atom. To understand the molecular basis for decarboxylative bromination in the biosynthesis of 1, we sequenced two Pseudoalteromonas genomes and identified a conserved four-gene locus encoding the enzymes involved in its complete biosynthesis. Through total in vitro reconstitution of the biosynthesis of 1 using purified enzymes and biochemical interrogation of individual biochemical steps, we show that all four bromine atoms in 1 are installed by the action of a single flavin-dependent halogenase: Bmp2. Tetrabromination of the pyrrole induces a thioesterase-mediated offloading reaction from the carrier protein and activates the biosynthetic intermediate for decarboxylation. Insights into the tetrabrominating activity of Bmp2 were obtained from the high-resolution crystal structure of the halogenase contrasted against structurally homologous halogenase Mpy16 that forms only a dihalogenated pyrrole in marinopyrrole biosynthesis. Structure-guided mutagenesis of the proposed substrate-binding pocket of Bmp2 led to a reduction in the degree of halogenation catalyzed. Our study provides a biogenetic basis for the biosynthesis of 1 and sets a firm foundation for querying the biosynthetic potential for the production of 1 in marine (meta)genomes.
Design of Ultra-Wideband, Aperiodic Antenna Arrays With the CMA Evolutionary Strategy (2013)

Recently, the covariance matrix adaption evolutionary strategy (CMA-ES) has received attention for outperforming conventional global optimization techniques such as the genetic algorithm (GA) or particle swarm optimization (PSO), often used in electromagnetic designs. Here, CMA-ES is first applied to the design of ultra-wideband aperiodic arrays using realistic spiral radiating elements. To improve the axial ratio of the array, optimization was extended to incorporate a mechanical rotation of each spiral element. This novel strategy of optimizing both the location and rotation of each element provides noticeable improvement in both the axial ratio and sidelobe level performance.
Performance of EUV photoresists on the ALS micro exposure tool (2005)

The new high NA (0.3) Micro Exposure Tool at the Advanced Light Source (MET@ALS) at Lawrence Berkeley National Laboratories provides the first opportunity to evaluate the ultimate resolution capabilities of chemically amplified resists using EUV lithography. We characterized the imaging capabilities of a well-known tool-test resist (EUV-2D, XP98248B) and a new high resolution resist (MET-1K, XP3454C). Emphasis was placed on evaluating resists for focus and exposure latitude at 50 nm dense and isolated lines. MET-1K is capable of resolving 30 nm lines and shows modulation in 25 nm dense lines. We describe some early process optimization experiments using MET-1K that show further advances in lithographic capability. Another new series of resists (MET-2A, 2B, 2C, 2D) also show great promise for good resolution, LER and sensitivity.
Hypercrosslinked polyanilines with nanoporous structure and high surface area: potential adsorbents for hydrogen storage (2007)

A method for the preparation of an entirely new type of nanoporous material, hypercrosslinked polyaniline, with permanent porous structure and specific surface areas exceeding 630 m2 g−1 has been developed. The hypercrosslinking reaction was carried out with commercial polyaniline and diiodoalkanes or paraformaldehyde using both conventional and microwave assisted processes. Polyaniline swollen in an organic solvent was hypercrosslinked to form a rigid, mesh-like structure with permanent porosity and a high surface area. The resulting materials were characterized using infrared spectroscopy and elemental analysis. Porous properties were determined by means of scanning electron microscopy as well as nitrogen and hydrogen adsorption. Short crosslinks such as those formed using paraformaldehyde and diiodomethane led to materials with the highest surface areas. Surface area also increased with the concentration of polyaniline in solution used during preparation. The hydrogen storage capacities of these materials were also tested and a capacity of 2.2 wt% at 77 K and 3.0 MPa was found for the best adsorbent. Hypercrosslinked polyanilines exhibit a remarkably high affinity for hydrogen, which results in enthalpies of adsorption as high as 9.3 kJ mol−1 (exothermic), in sharp contrast with hypercrosslinked polystyrenes and metal–organic frameworks for which significantly lower enthalpies of adsorption, typically in the range of 4–7 kJ mol−1, are measured.
Towards Optimal System Scheduling With Synthetic Inertia Provision From Wind Turbines (2020)

The undergoing transition from conventional to converter-interfaced renewable generation leads to significant challenges in maintaining frequency stability due to declining system inertia. In this paper, a novel control framework for Synthetic Inertia (SI) provision from Wind Turbines (WTs) is proposed, which eliminates the secondary frequency dip and allows the dynamics of SI from WTs to be analytically integrated into the system frequency dynamics. Furthermore, analytical system frequency constraints with SI provision from WTs are developed and incorporated into a stochastic system scheduling model, which enables the provision of SI from WTs to be dynamically optimized on a system level. Several case studies are carried out on a Great Britain 2030 power system with different penetration levels of wind generation and inclusion of frequency response requirements in order to assess the performance of the proposed model and analyze the influence of the improved SI control scheme on the potential secondary frequency dip. The results demonstrate that the inclusion of SI provision from WTs into Unit Commitment (UC) can drastically impact the overall system costs.
Analysis of achievable disturbance attenuation in a precision magnetically-suspended motion control system (1994)

The results of the analysis of the achievable disturbance attenuation to get an Angstrom motion control resolution and macroscopic travel in a precision magnetically-suspended motion control system are presented in this paper. Noise sources in the transducers, electronics, and mechanical vibrations are used to develop the control design.
Mammary tumor lipids and plasma lipoproteins in DMBA‐intubated rats fed olive or safflower oils (1990)

The effects of feeding olive and safflower oils on lipid and fatty acid composition of mammary tumors, plasma lipids and lipoproteins, and the nuclear magnetic resonance (NMR) spectra of plasma were investigated in rats. 7-12-Dimethylbenz[a]anthracene (DMBA)- and placebo-intubated male Sprague-Dawley rats were fed 20% fat diets containing 18:2n-6 (wt/wt) from either high-linoleic safflower oil (SL, 14.6% 18:2n-6), high oleic safflower oil (SO, 3.4% 18:2n-6), olive oil (OO, 1.1% 18:2n-6), or olive oil supplemented with 18:2n-6 (OL, 3.4% 18:2n-6) for 16 weeks. Our result indicated that tumor composition of 18:1n-9 and 18:2n-6 reflected the diet, but tumor neutral lipid (NL) was more reflective of diet than was tumor phospholipid (PL). The 20:4n-6 content of tumor PL was constant in all of the dietary groups despite threefold higher levels of 18:2n-6 in tumor PL from animals fed SL than from those fed SO, OO, or OL diets. This suggests a possible feedback inhibition of delta 6-desaturase by the higher content of 18:2n-6 associated with SL feeding No diet effects were obtained for tumor total lipid, NL, PL, cholesterol, and triglyceride contents. Plasma lipoprotein changes were more reflective of diet than tumorigenesis except for apolipoprotein-E, which was lower, and for very low-density lipoprotein cholesterol and low-density lipo protein, which were higher in tumor-bearing rats. Plasma NMR analysis indicated no difference in the average line widths of the methyl and methylene resonances for tumor-bearing and nontumor-bearing rats fed any of the diets.
Performance evaluation of fully embedded board level optical interconnection (2004)

We have made a thin flexible waveguide film for fully embedded board level optical interconnections. First, the master waveguide structures are formed on a silicon wafer using a standard photolithography process. Two 12-channel, 850 nm VCSEL arrays (2.5 Gb/s and 10 Gb/s) and a PIN photodiode array are used as I/O sources on a flexible polymeric waveguide film. The initial substrate thickness (200 /spl mu/m) of the VCSEL is reduced to facilitate thermal management of the VCSEL and the fully embedded structure.
High-throughput detection of RNA processing in bacteria (2016)

ABSTRACT Background Understanding the RNA processing of an organism's transcriptome is an essential but challenging step in understanding its biology. Here we investigate with unprecedented detail the transcriptome of Pseudomonas aeruginosa PAO1, a medically important and innately multi-drug resistant bacterium. We systematically mapped RNA cleavage and dephosphorylation sites that result in 5'-monophosphate terminated RNA using a new high-throughput methodology called monophosphate RNA-Seq (pRNA-Seq). Transcriptional start sites (TSS) were also mapped using differential RNA-Seq (dRNA-Seq) and both datasets were compared to conventional RNA-Seq performed in a variety of growth conditions. Results The pRNA-Seq transcript library revealed known tRNA, rRNA and tmRNA processing sites, together with previously uncharacterized RNA cleavage events that were found disproportionately near the 5' ends of transcripts associated with basic bacterial functions such as oxidative phosphorylation and purine metabolism. The majority (97%) of the processed mRNAs were cleaved at precise codon positions within defined sequence motifs indicative of distinct endonucleolytic activities. The most abundant of these motifs corresponded closely to an E. coli RNase E site previously established in vitro . Using the dRNA-Seq library, we performed an operon analysis and predicted 3,159 potential TSS. A correlation analysis uncovered 105 antiparallel pairs of TSS that were separated by 18 bp from each other and that were centered on a palindromic TAT(A/T)ATA motif, suggesting that such sites may provide a novel form of transcriptional regulation. TSS and RNA-Seq analysis allowed us to confirm expression of small non-coding RNAs (ncRNAs), many of which are differentially expressed in swarming and biofilm formation conditions. Conclusions This study introduces pRNA-Seq methodology, which provides the first comprehensive, genome-wide survey of RNA processing in any organism. As a proof of concept, we have employed this technique to study the bacterium Pseudomonas aeruginosa and have discovered extensive transcript processing not previously appreciated. We have also gained novel insight into RNA maturation and turnover as well as a potential novel form of transcription regulation. NOTE: All sequence data has been submitted to the NCBI short read archive. Accession numbers are as follows: [NCBI short read archive: SRX156386, SRX157659, SRX157660, SRX157661, SRX157683 and SRX158075]. The sequence data is viewable using Jbrowse on www.pseudomonas.com (example: http://tinyurl.com/pao1-prna-seq ). (An example of certain tracks is shown for convenience, but other tracks of data can be displayed using the “select tracks” option, and tracks may be clicked on and dragged to re-order them.)
Adsorption of Modified HIV-1 Capsid p24 Protein onto Thermosensitive and Cationic Core−Shell Poly(styrene)−Poly(N-isopropylacrylamide) Particles (2000)

The adsorption of HIV-1 capsid p24 protein bearing six histidine residues (named RH24) onto well-characterized thermosensitive and cationic poly(styrene)−poly(N-isopropylacrylamide) core−shell particles was investigated as a function of temperature, pH, incubation time, and salinity. The maximum amount of adsorbed RH24 was observed when the temperature was above the lower critical solution temperature (LCST) of the hydrogel, whereas a negligible adsorbed amount occurred below the LCST. Adsorption isotherms were then determined above the LCST and exhibited well-defined plateaus, which were pH and ionic strength dependent. Isotherm data were tentatively discussed using the Freundlich power law, from which the standard free enthalpy of protein adsorption was estimated. The adsorption behavior of protein was mainly governed by hydrophobic interactions above the LCST; however, differences between the two latexes gave evidence that electrostatic forces also played a significant role.
Cilia and coordination of signaling networks during heart development (2013)

Primary cilia are unique sensory organelles that coordinate a wide variety of different signaling pathways to control cellular processes during development and in tissue homeostasis. Defects in function or assembly of these antenna-like structures are therefore associated with a broad range of developmental disorders and diseases called ciliopathies. Recent studies have indicated a major role of different populations of cilia, including nodal and cardiac primary cilia, in coordinating heart development, and defects in these cilia are associated with congenital heart disease. Here, we present an overview of the role of nodal and cardiac primary cilia in heart development.
Achieving Any Dominant Stiffness Matrix With a Parallel Elastic Mechanism (2002)

ACTA Press publishes numerous technical publications, scientific journals for modeling, simulations and research papers for international conferences in the general areas of engineering and computer science.
An Unusual Sex Steroid-Binding Protein in Mature Male Rat Liver Cytosol* (1978)

Mature male rat liver cytosol contains a moderate affinity and capacity estrogen-binding protein in at least a 200-fold higher level than mature female or immature male rat liver cytosol. Binding of estradiol to this protein is very rapid, is stabilized by EDTA, and is inhibited by divalent cations. This is the major binding protein for [3H]estradiol ([3H]E2) in mature male rat liver cytosol, and it has properties clearly distinguishing it from putative liver or uterine estrogen receptors. In addition to binding [3H]E2, this protein seems to rapidly bind a [3H]5alpha-dihydrotestosterone ([3H]DHT) metabolite at the same binding site. The binding of this androgen metabolite is stabilized by EDTA and is inhibited by divalent cations. The binding properties of the [3H]DHT metabolite suggest that these binding sites are not classical androgen receptors. Cytosol binding levels of both the [3H]E2 and the [3H]DHT metabolites change in a similar direction in resonse to endocrine manipulation. The putative liver estrogen receptor level, determined after partial purification (in a redissolved 30% ammonium sulfate-precipitated fraction), seems to change in an opposite direction in response to these same endocrine manipulations.
Interface pressures and shear stresses (1999)

Interface pressures and shear stresses at different sagittal plane angular alignment settings were measured on 3 trans-tibial amputee subjects ambulating with patellar-tendon-bearing total contact prostheses. Substantial socket-shank angular alignment modifications in the sagittal plane had minimal effect on stance phase peak interface pressures, though more substantial effects on stance phase peak resultant shear stresses. No consistent trend of a greater stress at misaligned vs nominally aligned settings was identified. Changes in interface stresses from session to session tended to be greater than those for different alignment settings, suggesting that subjects compensated well for misalignments but less well for session differences.
Low temperature Direct Bonding of SiN and SiO interfaces for packaging applications (2020)

New challenges in packaging arise as the pitch of the first-level-interconnects shrinks below what can be achieved with solder joints. Hybrid bonding, including direct Cu-Cu bonding, is a promising solution but faces significant integration challenges.In this study, which is focused on potential use of direct bond technology for packaging applications, a model for quantifying the impact of wafer/substrate thickness to bond wave speed is presented and validated. Then, a low temperature deposited Silicon Nitride (SiN) surface is studied for both symmetrical and asymmetrical bonds. Guidance on densification needs, best surface preparation, and annealing condition to achieve sufficient bonding energy and void free bonding are reported for each interface type with low annealing temperature conditions (≤200°C). This ensures a solution can be leveraged for advance packaging applications.
Investigation on error factor of injection molding plastic for freeform optics (2007)

2007-2008 > Academic research: refereed > Publication in refereed journal
Physical Activity and Television Viewing in Relation to Risk of Undiagnosed Abnormal Glucose Metabolism in Adults (2004)

These findings suggest a protective effect of physical activity and a deleterious effect of TV time on the risk of abnormal glucose metabolism in adults. Population strategies to reduce risk of abnormal glucose metabolism should focus on reducing sedentary behaviors such as TV time, as well as increasing physical activity.
Nuclear Waste Management (1984)

Papers from the Second International Symposium on Ceramics in Nuclear Waste Management, held during the American Ceramic Society's 85th Annual Meeting, comprise this eighth volume in the Advances in Ceramics series. The 81 papers included in this volume were compiled by George G. Wicks, of Savannah River Lab, and Wayne A. Ross, of Battelle, Pacific Northwest Labs.
Experimental investigation of subcooled liquid nitrogen impingement cooling of a silicon chip (1995)

A technique was developed to facilitate subcooled pool boiling and jet impingement boiling of liquid nitrogen at the surface of a silicon chip by varying the dewar pressure while maintaining the bath temperature constant at about 78 K. Subcooling levels of up to 10 K could be easily reached by pressurizing the liquid nitrogen bath with helium gas. Convective and boiling impingement cooling of up to 80 W/cm/sup 3/ from a silicon chip has been measured for a submerged subcooled liquid nitrogen jet.
Figure S1 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer (2023)

&lt;p&gt;Supplemental Figure S1. Rapid derivation of PDAC cells in culture&lt;/p&gt;
Formation of Nickeladihydropyran by Oxidative Addition of Cyclopropyl Ketone. Key Intermediate in Nickel-Catalyzed Cycloaddition (2006)

Cyclopropyl phenyl ketone underwent oxidative addition to Ni(PCy3) generated from Ni(cod)2 and PCy3 to give a nickeladihydropyran, which is a key intermediate for the Ni(0)-catalyzed homo- or heterocycloaddition to give cyclopentane compounds having two carbonyl substituents at the 1,3-position.
Integrated all-digital low-dropout regulator as a countermeasure to power attack in encryption engines (2016)

Low-drop-out (LDO) voltage regulator modules are being increasingly integrated in the modern processors for efficient power management. This paper shows that an integrated All-Digital LDO (ADLDO) can also be used as a countermeasure against power measurement based side channel attacks. The current transformation introduced by integrated digital LDOs, coupled with the noise due to quantization and limited sampling rate in the control loop, helps suppress the side channel leakage. The ADLDO-based countermeasure is analyzed considering an Advanced Encryption Standard (AES) engine designed in 130nmCMOS. Correlation power analysis and signal-to-noise ratio of the current waveforms at the input of the ADLDO shows significant improvement in power attack resistance over the AES input current.
Adaptive range‐measurement‐based target pursuit (2012)

SUMMARY This paper presents an adaptive scheme for localization of a target from distance measurements and motion control of a mobile agent to pursue this target. The localization and motion control task of interest is approached within a parameter‐identifier‐based adaptive control framework, where the localization is formulated as a parameter identification problem and the motion control is achieved using an adaptive controller based on the produced location estimates of the target. First, a robust adaptive law is designed to generate location estimate of the target using distance measurements. Then, following the standard certainty equivalence approach, a motion control law is developed considering substitution of the estimate generated by the localization algorithm for the unknown location of the target. Noting that there is some incompatibility between the persistence of excitation requirements of the localization algorithm and the target pursuit goal of the motion control law, the base motion control law is (re)designed to eliminate the effects of this incompatibility. The novelty of this paper is in this motion control design eliminating the persistence of excitation incompatibility. Stability and convergence analysis for the overall adaptive control scheme is presented. The results are valid in both two and three dimensions of motion space. The applications of the adaptive scheme include rescue localization, surveillance of signal sources, and formation acquisition of autonomous multi‐robot/vehicle systems. Copyright © 2012 John Wiley &amp; Sons, Ltd.
[Dangerous reduction of blood flow in the internal mammary artery in acute hypovolemia]. (1990)

Internal mammary artery (IMA) flow patterns were analyzed in a dog model without interference with the coronary artery bed (n = 6, mean bodyweight: 21 +/- 4 kg) during the following conditions: a) baseline values and steady state: b) acute hypovolemia (withdrawal of 20% of circulating volume over 90 s): c) retransfusion (same volume over 90 s): d) progressive hypovolemia (withdrawal of the same volume over 240 s): e) bolus of nitrates (500 micrograms/kg over 60 s).