gebhart/patrepeval huggingface dataset:
Burkholderia thailandensis oacA Mutants Facilitate the Expression of Burkholderia mallei -Like O Polysaccharides (2010)

Previous studies have shown that the O polysaccharides (OPS) expressed by Burkholderia mallei are similar to those produced by Burkholderia thailandensis except that they lack the 4-O-acetyl modifications on their 6-deoxy-α-l-talopyranosyl residues. In the present study, we describe the identification and characterization of an open reading frame, designated oacA, expressed by B. thailandensis that accounts for this phenomenon. Utilizing the B. thailandensis and B. mallei lipopolysaccharide (LPS)-specific monoclonal antibodies Pp-PS-W and 3D11, Western immunoblot analyses demonstrated that the LPS antigens expressed by the oacA mutant, B. thailandensis ZT0715, were antigenically similar to those produced by B. mallei ATCC 23344. In addition, immunoblot analyses demonstrated that when B. mallei ATCC 23344 was complemented in trans with oacA, it synthesized B. thailandensis-like LPS antigens. To elucidate the structure of the OPS moieties expressed by ZT0715, purified samples were analyzed via nuclear magnetic resonance spectroscopy. As predicted, these studies demonstrated that the loss of OacA activity influenced the O acetylation phenotype of the OPS moieties. Unexpectedly, however, the results indicated that the O methylation status of the OPS antigens was also affected by the loss of OacA activity. Nonetheless, it was revealed that the LPS moieties expressed by the oacA mutant reacted strongly with the B. mallei LPS-specific protective monoclonal antibody 9C1-2. Based on these findings, it appears that OacA is required for the 4-O acetylation and 2-O methylation of B. thailandensis OPS antigens and that ZT0715 may provide a safe and cost-effective source of B. mallei-like OPS to facilitate the synthesis of glanders subunit vaccine candidates.
Synthesis and characterization of new soluble polyamides derived from 3,3′,5,5′‐tetramethyl‐2,2‐bis[4‐(4‐carboxyphenoxy)phenyl]propane (1999)

A series of new soluble polyamides having isopropylidene and methyl-substituted arylene ether moieties in the polymer chain were prepared by the direct polycondensation of 3,3′,5,5′-tetramethyl-2,2-bis[4-(4-carboxyphenoxy)phenyl]propane and various diamines in N-methyl-2-pyrrolidinone (NMP) containing CaCl2 using triphenyl phosphite and pyridine as condensing agents. Polymers were produced with moderate to high inherent viscosities of 0.85–1.47 dL g−1 while the weight-average molecular weight and number-average molecular weight were in the range of 86,700–259,000 and 43,300–119,000, respectively. All the polymers were readily dissolved in polar aprotic solvents such as NMP, N,N-dimethylacetamide, and N,N-dimethylformamide, as well as less polar solvents such as m-cresol and pyridine, and even soluble in tetrahydrofuran. These polymers were solution-cast into transparent, flexible and tough films. All of the polymers were amorphous and the polyamide films had a tensile strength range of 82–122 MPa, an elongation at break range of 6–18%, and a tensile modulus range of 2.0–2.8 GPa. These polyamides had glass transition temperatures between 233–260°C and 10% weight loss temperatures in the range of 450–489 and 459–493°C in nitrogen and air atmosphere, respectively. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 1997–2003, 1999
Synthesis of medium ring azacycles via allene-based cyclisations: evaluation of possible mechanistic pathways (1994)

Two pathways have been evaluated to account for the l2-mediated cyclisation of the allenic sulfonamides 1a–e based on (i) the steric demands of the allenic unit and (ii) the ambident reactivity of the sulfonamide anion. The 1, 3-disubstituted allenic sulfonamides 6 and 7 have been prepared and both undergo a facile cyclisation, without the need of an external base, to give the smaller of the two possible ring sizes 8 and 11, respectively. In the case of 7, the intermediate allylic iodides 9 and 10 have been observed and steric factors appear to play a decisive role in determining the preference for ring size in this cyclisation sequence. A possible role for the sulfonamide unit acting as an ambident nucleophile by undergoing initial O-alkylation has also been examined. The sulfonimidates 15a–c undergo thermal [3,3]-rearrangement to give the corresponding sulfonamides 16a–c but the conditions required to achieve this O- to N-migration step would preclude involvement of this pathway in the l2-mediated cyclisation of allenic sulfonamides.
Distinct IFNG methylation in a subset of ulcerative colitis patients based on reactivity to microbial antigens (2010)

Levels of IFNG methylation were correlated with immune response to microbial components and expression of IFN-γ in UC patients. Serological and epigenetic markers identify a subset of UC patients with an expression profile of a key TH1 pathogenic cytokine. These data may provide a useful tool to classify a more homogeneous subset of UC patients, allowing for improved diagnostics and targeted therapeutics.
Augmentation-Interpolative AutoEncoders for Unsupervised Few-Shot Image Generation (2020)

We aim to build image generation models that generalize to new domains from few examples. To this end, we first investigate the generalization properties of classic image generators, and discover that autoencoders generalize extremely well to new domains, even when trained on highly constrained data. We leverage this insight to produce a robust, unsupervised few-shot image generation algorithm, and introduce a novel training procedure based on recovering an image from data augmentations. Our Augmentation-Interpolative AutoEncoders synthesize realistic images of novel objects from only a few reference images, and outperform both prior interpolative models and supervised few-shot image generators. Our procedure is simple and lightweight, generalizes broadly, and requires no category labels or other supervision during training.
Relationship of retrovirus polyprotein cleavages to virion maturation studied with temperature-sensitive murine leukemia virus mutants (1978)

Murine leukemia virus mutants ts3 (Moloney) and ts24 (Rauscher) both formed late-budding structures on the cell membrane at restrictive temperature. They both accumulated core polyproteins Pr65gag and Pr180gag-pol in cell membranes, but the envelope precursor was rapidly turned over. After shift to permissive temperature in the presence of cycloheximide, the accumulated precursors were sequentially cleaved via discrete intermediates both during the final stages of the budding process and in newly released virions to yield the finished virion core proteins and reverse transcriptase. The precursor form of reverse transcriptase was not enzymatically active and became activated partially or entirely inside released virions.
Photoelectron spectroscopy in chemistry (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoelectron spectroscopy in chemistryS. D. WorleyCite this: Chem. Rev. 1971, 71, 3, 295–314Publication Date (Print):June 1, 1971Publication History Published online1 May 2002Published inissue 1 June 1971https://pubs.acs.org/doi/10.1021/cr60271a002https://doi.org/10.1021/cr60271a002research-articleACS PublicationsRequest reuse permissionsArticle Views463Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pyrazindioxid‐Tetracyanethylen‐Assoziate im Festkörper ‐ neuartige Donor‐Acceptor‐Wechselwirkungen für das Kristall‐Engineering (1997)

Leitern bzw. Netze liegen in den beiden polymorphen Formen der durch unterschiedlich rasches Kristallwachstum erhaltenen Kristalle von (TMPDO) 2 TCNE vor. In kinetisch bevorzugten, purpurfarbenen Kristallen sind die Donor‐ und Acceptorbausteine über N + O − … C(Alken)‐Wechselwirkungen zu Leitern organisiert (siehe unten). magnified image
Ultraviolet-Enduring Performance of Flexible Pentacene TFTs with SnO[sub 2] Encapsulation Films (2006)

We report on the fabrication of flexible pentacene thin-film transistors (TFTs) encapsulated with an ultraviolet (UV)-protecting thin-film that has been prepared by ion-beam-assisted deposition (IBAD). We deposited thermally evaporated on a pentacene TFT as a buffer layer prior to the IBAD process. When a UV light of wavelength was continuously illuminated onto our encapsulated device for periods of 5, 30, 60, and under a vacuum of , its field mobility gradually degraded from 0.34 to in while the other device without encapsulation rapidly degraded (its mobility was reduced to during the same period). Our X-ray diffraction data indicates that the UV-induced-degradation of device characteristics is directly correlated to the degradation of pentacene crystallinity against UV radiation. We conclude that our IBAD encapsulation is a promising way to protect pentacene TFTs.
A new atom transfer radical polymerization initiator based on phenolphthalein for the synthesis of bis‐allyloxy functionalized polystyrene macromonomers (2014)

Abstract A new atom transfer radical polymerization ( ATRP ) initiator, namely 2‐(1,1‐bis(4‐(allyloxy)phenyl)‐3‐oxoisoindolin‐2‐yl)ethyl 2‐bromo‐2‐methylpropanoate, was synthesized starting from phenolphthalein, a commercially available and an inexpensive chemical. Well‐ defined bis‐allyloxy functionalized polystyrene macromonomers ( M n, GPC 4800–11 700 g mol −1 ) with controlled molecular weight and narrow molecular weight distribution (1.05–1.09) were synthesized using ATRP by varying the monomer to initiator feed ratio. The presence of allyloxy functionality on polystyrene was confirmed by Fourier transform infrared and 1 H NMR spectroscopy. A kinetic study of polymerization revealed pseudo‐first‐order kinetics with respect to monomer consumption. Initiator efficiency was found to be in the range 0.80–0.95. Matrix‐assisted laser desorption ionization time of flight spectra showed a narrow molecular weight distribution with control over the molecular weight. The reactivity of the allyloxy groups on polystyrene was successfully demonstrated by quantitative photochemical thiol‐ene click reaction with benzyl mercaptan as the model thiol reagent. Furthermore, the thiol‐ene click reaction was exploited to introduce other reactive functional groups such as hydroxyl and carboxyl by reaction of α,α′‐bis‐allyloxy functionalized polystyrene with 2‐mercaptoethanol and 3‐mercaptopropionic acid, respectively. © 2014 Society of Chemical Industry
Analysis of Finnish Blue Mussel (<em>Mytilus edulis</em> L.) Shell: Biomineral Ultrastructure, Organic-Rich Interfacial Matrix and Mechanical Behavior (2021)

Studying various marine biomineralized ultrastructures reveals the appearance of common architectural designs and building blocks in materials with fascinating mechanical properties that match perfectly to their biological tasks. Advanced mechanical properties of biological materials are attributed to evolutionary optimized molecular architectures and structural hierarchy. One example which has not yet been structurally investigated in great detail is the shell of Mytilus edulis L. (Finnish blue mussel) found in the archipelago of SW-Finland. Through a combination of various state-of-the-art techniques such as high-resolution electron microscopy imaging, Fourier-transformed infrared spectroscopy, powder X-ray diffraction, synchrotron wide-angle X-ray diffraction, nanoindentation and protein analysis, both the inorganic mineralized components as well as the organic-rich matrix were extensively characterized. We found very similar ultra-architecture across the shell of M. edulis L. as compared to the widely studied and closely related M. edulis. However, we also found interesting differences, for instance in the thickness and degree of orientation of the mineralized layers indicating dissimilar properties and related alterations in the biomineralization processes. Our results show that the shell of M. edulis L. has a gradient of mechanical properties, with the increase in the stiffness and the hardness from anterior to the posterior region of the shell. The shell is made from distinct and recognizable mineralized layers each varying in thickness and microstructural features. At posterior regions of the shell, moving from dorsal to ventral side, these layers are an oblique prismatic layer, a prismatic layer and a nacreous layer, in which the oblique prismatic layer is found to be the main and thickest mineralized layer of the shell. Probing the calcified rods in the oblique prismatic layer using high resolution SEM imaging revealed opening of channels with a diameters of 40-50 nm and lengths up to a micrometer extending through the rods. The chitin and protein have been found to be the main component of the organic-rich interfacial matrix as expected. Protein analysis showed two abundant proteins with sizes around 100 kD and 45 kD which likely not only regulates biomineralization and adhesion of the crystals but also governing the intrinsic-extrinsic toughening in the shell. Overall, this detailed analysis provides new structural insights into biomineralization of marine shells in general.
Space-Time Block Coding for Wireless Communications (2003)

Space-time coding is a technique that promises greatly improved performance in wireless networks by using multiple antennas at the transmitter and receiver. Space-Time Block Coding for Wireless Communications, first published in 2003, is an introduction to the theory of this technology. The authors develop the topic using a unified framework and cover a variety of topics ranging from information theory to performance analysis and space-time coding methods for both flat and frequency-selective fading multiple-antenna channels. The authors concentrate on key principles rather than specific practical applications, and present the material in a concise and accessible manner. Their treatment reviews the fundamental aspects of multiple-input, multiple-output communication theory, and guides the reader through a number of topics at the forefront of research and development. The book includes homework exercises and is aimed at graduate students and researchers working on wireless communications, as well as practitioners in the wireless industry.
Pitch-based carbon foam and composites and uses thereof (2023)

A thermally conductive carbon foam is provided, normally having a thermal conductivity of at least 40 W/m.multidot.K. The carbon foam usually has a specific thermal conductivity, defined as the thermal conductivity divided by the density, of at least about 75 W.multidot.cm.sup.3 /m.multidot..degree.K.multidot.gm. The foam also has a high specific surface area, typically at least about 6,000 m.sup.2 /m.sup.3. The foam is characterized by an x-ray diffraction pattern having "doublet" 100 and 101 peaks characterized by a relative peak split factor no greater than about 0.470. The foam is graphitic and exhibits substantially isotropic thermal conductivity. The foam comprises substantially ellipsoidal pores and the mean pore diameter of such pores is preferably no greater than about 340 microns. Other materials, such as phase change materials, can be impregnated in the pores in order to impart beneficial thermal properties to the foam. Heat exchange devices and evaporatively cooled heat sinks utilizing the foams are also disclosed.
Decentralized RLS with Data-Adaptive Censoring for Regressions over Large-Scale Networks (2016)

The deluge of networked data motivates the development of algorithms for computation- and communication-efficient information processing. In this context, three data-adaptive censoring strategies are introduced to considerably reduce the computation and communication overhead of decentralized recursive least-squares (D-RLS) solvers. The first relies on alternating minimization and the stochastic Newton iteration to minimize a network-wide cost, which discards observations with small innovations. In the resultant algorithm, each node performs local data-adaptive censoring to reduce computations, while exchanging its local estimate with neighbors so as to consent on a network-wide solution. The communication cost is further reduced by the second strategy, which prevents a node from transmitting its local estimate to neighbors when the innovation it induces to incoming data is minimal. In the third strategy, not only transmitting, but also receiving estimates from neighbors is prohibited when data-adaptive censoring is in effect. For all strategies, a simple criterion is provided for selecting the threshold of innovation to reach a prescribed average data reduction. The novel censoring-based (C)D-RLS algorithms are proved convergent to the optimal argument in the mean-square deviation sense. Numerical experiments validate the effectiveness of the proposed algorithms in reducing computation and communication overhead.
Olfaction shapes host–parasite interactions in parasitic nematodes (2012)

Many parasitic nematodes actively seek out hosts in which to complete their lifecycles. Olfaction is thought to play an important role in the host-seeking process, with parasites following a chemical trail toward host-associated odors. However, little is known about the olfactory cues that attract parasitic nematodes to hosts or the behavioral responses these cues elicit. Moreover, what little is known focuses on easily obtainable laboratory hosts rather than on natural or other ecologically relevant hosts. Here we investigate the olfactory responses of six diverse species of entomopathogenic nematodes (EPNs) to seven ecologically relevant potential invertebrate hosts, including one known natural host and other potential hosts collected from the environment. We show that EPNs respond differentially to the odor blends emitted by live potential hosts as well as to individual host-derived odorants. In addition, we show that EPNs use the universal host cue CO(2) as well as host-specific odorants for host location, but the relative importance of CO(2) versus host-specific odorants varies for different parasite-host combinations and for different host-seeking behaviors. We also identified host-derived odorants by gas chromatography-mass spectrometry and found that many of these odorants stimulate host-seeking behaviors in a species-specific manner. Taken together, our results demonstrate that parasitic nematodes have evolved specialized olfactory systems that likely contribute to appropriate host selection.
GNPy Experimental Validation for Nyquist Subcarriers Flexible Transmission up to 800 G (2022)

We test the performance of Nyquist subcarriers flexible transponders up to 800 Gbit/s over a 20 × 80-km optical link operated at full WDM spectral load, obtaining excellent accuracy in GSNR and optimal power predictions using GNPy.
Asymptotic Analysis of MIMO Multi-Cell Full-Duplex Networks (2017)

We study a multi-cell multi-user MIMO full-duplex network, where each base station (BS) has multiple antennas with full-duplex capability supporting single-antenna users with either full-duplex or half-duplex radios. We characterize the up- and downlink ergodic achievable rates for the case of linear precoders and receivers. The rate analysis includes practical constraints, such as imperfect self-interference cancellation, channel estimation error, training overhead, and pilot contamination. We show that the $2\times $ gain of full duplex over half-duplex system remains in the asymptotic regime, where the number of BS antennas grows infinitely large. We numerically evaluate the finite SNR and antenna performance, which reveals that full-duplex networks can use significantly fewer antennas to achieve spectral efficiency gain over the half-duplex counterparts. In addition, the overall full-duplex gains can be achieved under realistic 3GPP multi-cell network settings despite the increased interference introduced in the full-duplex networks.
Dose-Escalation with BEACOPP Escalated Is Superior to ABVD In the Combined-Modality Treatment of Early Unfavorable Hodgkin Lymphoma: Final Analysis of the German Hodgkin Study Group (GHSG) HD14 Trial (2010)

Abstract Abstract 765 Purpose: Combined modality treatment consisting of 4 cycles of chemotherapy and IF-RT is the standard treatment for early unfavorable HL. Overall survival (OS) and freedom from treatment failure (FFTF) at 5 years in this group of patients was 91% and 83%, respectively, in our prior HD8 study. Thus, the rationale for HD14 was to improve on these results by increasing dose intensity using BEACOPP escalated. Methods: Between January 2003 and July 2008, 1655 patients with histologically confirmed diagnosis of Hodgkin lymphoma in early unfavorable stages were randomized. Patients had to be 16–60 years old and have CS I, IIA with one of the following risk factors: large mediastinal mass (a), extranodal disease (b), elevated ESR (c), or ≥ 3 nodal areas (d), IIB with risk factors c or d). Patients were randomized to either 4 cycles of ABVD (arm A) or 2 cycles BEACOPP escalated followed by 2 cycles ABVD (arm B). All patients received 30Gy IF-RT after chemotherapy. Primary objective was the improvement of FFTF. Results: The full analysis set comprised 1623 patients (98.1%) who were documented and followed for treatment effects; 818 were in arm A and 805 in arm B. Patient characteristics were well balanced between the two arms with a median age of 33.6 years and most patients in stage IIA (67%). The overall response rate to treatment was 95% in each arm. With a median follow-up of 42.4 months, 20 patients had died in each arm; 19 patients in arm A had secondary neoplasia compared to 16 patients in arm B. Progressive disease was observed in 2.9% versus 0.9% of patients in arms A and B, respectively; early relapse rates were 2.8% versus 0.9%, and late relapse rates were 2.3% versus 0.9%. The estimated 4-year FFTF rate was 89.3% in arm A and 94.7% in arm B (p=0,0001, hazard ratio HR=2.04, 95%-CI: 1.39–2.94). There was no significant difference in overall survival yet (p=0.95). Acute grade III-IV toxicity rates of chemotherapy were higher in arm B (87.1%) than in arm A (50.7%) with leucopenia rates of 79% versus 24%, hair loss 48% versus 24%, thrombocytopenia 22% versus 0.1% and anemia 9% versus 1% in arms B and A respectively. 7.3% of patients had grade III/IV infections in arm B as compared to 3.4% in arm A. However, we observed no differences in treatment-related death or secondary neoplasia rates between treatment arms. Conclusion: Intensifying treatment for patients with early unfavorable HL using 2 cycles of BEACOPP escalated followed by 2 × ABVD and IFRT results in a significant improvement in tumor control as compared to our prior standard of 4 × ABVD plus IFRT. As defined in the study protocol, this more aggressive treatment was implemented as new standard of care for early unfavorable HL in our follow-up study (GHSG HD17). Disclosures: Greil: Cephalon: Research Funding.