gebhart/patrepeval huggingface dataset:
Royal Jelly Supplementation Improves Lipoprotein Metabolism in Humans (2007)

Royal jelly (RJ) has several physiological effects and is widely used in commercial medical products and health foods. We examined the effects of RJ supplementation on serum lipoprotein metabolism in humans. Fifteen volunteers were divided into an RJ intake group (n=7) and a control group (n=8). The RJ group took 6 g per day for 4 wk. Their serum total cholesterol (TC) and serum low-density lipoprotein (LDL) decreased significantly compared with those of the control group (p<0.05). There were no significant differences in serum high-density lipoprotein (HDL) or triglyceride concentrations. Moreover, the relationship between the serum cholesterol and lipoprotein levels was investigated. Among the lipoprotein fractions, small very-low-density lipoprotein was decreased (p<0.05) after RJ intake. Our results suggest that dietary RJ decreases TC and LDL by lowering small VLDL levels.
Evaluation of Topoisomerase‐1‐Specific CD8+ T‐Cell Response in Systemic Sclerosis (2005)

Measurement of disease activity in systemic autoimmune disorders is often unreliable, and immunosuppressive therapy is often titrated to crude clinical response and/or onset of complications. Systemic sclerosis (SSc) presents a distinct clinical phenotype associated with specific autoantibodies. Anti-topoisomerase-1 (SCL-70) is selectively detected in 30-60% of subjects with diffuse skin and interstitial lung involvement. Such patients offer an ideal clinical model to characterize and quantify the autoantigen-specific T-cell response and its correlation with disease phenotype and activity. Human leukocyte antigen A2 (HLA-A2)-restricted topo-1 peptides were selected based on an epitope prediction algorithm. For initial studies, the best binder topo-1(262-270) KMLDHEYTT (#262) was used alone or loaded onto an artificial antigen-presenting platform generated by coupling a dimeric major histocompatibility complex-immunoglobulin G fusion protein (HLA-A2-Ig) and anti-CD28 antibodies onto magnetic beads (artificial antigen-presenting cells). Blood samples (100 microL) from HLA-A2+ SSc patients and cytomegalovirus (CMV) seropositive healthy control subjects were tested in an intracellular cytokine staining assay. Gamma interferon production by CD8+ T cells was measured after stimulation with peptide #262, CMVpp65, or MART-1 (irrelevant peptide). In two of five SCL-70+ patients, peptide #262-loaded aAPCs induced a specific CD8+ T-cell response (0.45% +/- 0.23% of total CD8+ cells). This response was not observed in the seven SCL-70- (five SSc and two CMV+) control subjects studied (0.03% +/- 0.02%). Interestingly, bronchoalveolar lavage fluid obtained from one topo-1-responsive SSc patient who had worsening respiratory function and active alveolitis showed striking enrichment of topo-1-specific CD8+ T cells (3.94%). This small-volume ex vivo assay may prove to be a sensitive and specific tool to assess disease activity and to monitor response to therapy in patients with scleroderma.
Effects of the Selective EP2 Receptor Agonist Omidenepag on Adipocyte Differentiation in 3T3-L1 Cells (2020)

<b><i>Purpose:</i></b> We aimed at comparing the effects of omidenepag (OMD) with those of prostaglandin F (FP) receptor agonists (FP agonists) on adipogenesis in mouse 3T3-L1 cells. <b><i>Methods:</i></b> To evaluate the agonistic activities of OMD against the mouse EP2 (mEP2) receptor, we determined cAMP contents in mEP2 receptor-expressing CHO cells by using radioimmunoassays. Overall, 3T3-L1 cells were cultured in differentiation medium for 10 days and adipocyte differentiation was assessed according to Oil Red O-stained cell areas. Changes in expression levels of the adipogenic transcription factors <i>Pparg</i>, <i>Cebpa</i>, and <i>Cebpb</i> were determined by using real-time polymerase chain reaction (PCR). OMD at 0.1, 1, 10, and 40 μmol/L, latanoprost free acid (LAT-A) at 0.1 μmol/L, or prostaglandin F<sub>2α</sub> (PGF<sub>2α</sub>), at 0.1 μmol/L were added to cell culture media during adipogenesis. Oil Red O-stained areas and expression patterns of transcription factor targets of OMD or FP agonists were compared with those of untreated controls. <b><i>Results:</i></b> The 50% effective concentration (EC<sub>50</sub>) of OMD against the mEP2 receptor was 3.9 nmol/L. Accumulations of Oil Red O-stained lipid droplets were observed inside control cells on day 10. LAT-A and PGF<sub>2α</sub> significantly inhibited the accumulation of lipid droplets; however, OMD had no effect on this process even at concentrations up to 40 μmol/L. LAT-A and PGF<sub>2α</sub> significantly suppressed <i>Pparg</i>, <i>Cebpa</i>, and <i>Cebpb</i> gene expression levels during adipocyte differentiation. Conversely, OMD had no obvious effects on the expression levels of these genes. <b><i>Conclusions:</i></b> A selective EP2 receptor agonist, OMD, did not affect the adipocyte differentiation in 3T3-L1 cells, whereas FP agonists significantly inhibited this process.
Classification of combined partial knee arthroplasty (2019)

We recommend bi-unicondylar arthroplasty (Bi-UKA), medial bicompartmental arthroplasty (BCA-M), lateral bicompartmental arthroplasty (BCA-L), and tricompartmental arthroplasty (TCA) as the preferred terms to classify CPKA procedures. Cite this article: <i>Bone Joint J</i> 2019;101-B:922-928.
A Reductive Alkylation Procedure Applicable to Both Solution- and Solid-Phase Syntheses of Secondary Amines (1996)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTA Reductive Alkylation Procedure Applicable to Both Solution- and Solid-Phase Syntheses of Secondary AminesAnna K. Szardenings, Timothy S. Burkoth, Gary C. Look, and David A. CampbellView Author Information Affymax Research Institute, 4001 Miranda Avenue, Palo Alto, California 94304 Cite this: J. Org. Chem. 1996, 61, 19, 6720–6722Publication Date (Web):September 20, 1996Publication History Received19 January 1996Revised19 June 1996Published online20 September 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jo960124nhttps://doi.org/10.1021/jo960124nbrief-reportACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views1230Altmetric-Citations99LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alcohols,Aldehydes,Amines,Oligomers,Post-translational modification Get e-Alerts
Allelic variants of IL1R1 gene associate with severe hand osteoarthritis (2010)

Background In search for genes predisposing to osteoarthritis (OA), several genome wide scans have provided evidence for linkage on 2q. In this study we targeted a 470 kb region on 2q11.2 presenting the locus with most evidence for linkage to severe OA of distal interphalangeal joints (DIP) in our genome wide scan families. Methods We genotyped 32 single nucleotide polymorphisms (SNPs) in this 470 kb region comprising six genes belonging to the interleukin 1 superfamily and monitored for association with individual SNPs and SNP haplotypes among severe familial hand OA cases (material extended from our previous linkage study; n = 134), unrelated end-stage bilateral primary knee OA cases (n = 113), and population based controls (n = 436). Results Four SNPs in the IL1R1 gene, mapping to a 125 kb LD block, provided evidence for association with hand OA in family-based and case-control analysis, the strongest association being with SNP rs2287047 (p-value = 0.0009). Conclusions This study demonstrates an association between severe hand OA and IL1R1 gene. This gene represents a highly relevant biological candidate since it encodes protein that is a known modulator of inflammatory processes associated with joint destruction and resides within a locus providing consistent evidence for linkage to hand OA. As the observed association did not fully explain the linkage obtained in the previous study, it is plausible that also other variants in this genome region predispose to hand OA.
Electronic transitions in a Ge-rich strain-symmetrized Si8Ge32 superlattice measured by photoreflectance spectroscopy (1990)

Using photoreflectance spectroscopy, fifteen electronic transitions have been measured from a 60 period Si8Ge32 superlattice grown on a Si02Ge0•8 buffer layer on < 100 > Si. The superlattice transitions fit well to a third derivative functional form and most of their energies were determined using a one band envelope-function model, including strain effects. The temperature dependences of the E0 transition in bulk Ge and in the Si8Ge32 superlattice were also fit to a nonlinear functional form.
70% Energy Saving in Wireless Positioning Systems: Non-Data-Bearing OFDM Transmission Replaces Non-Pulse-Shaping PN Transmission (2013)

This paper investigates the green characteristic of the non-data-bearing orthogonal frequency-division multiplexing (NDB OFDM) transmission in wireless localization, relative to being widely used non-pulse-shaping pseudorandom noise (NPS PN) transmission in current satellite- and ground-based positioning systems. For obtaining a fixed ranging accuracy, the required NDB OFDM transmit energy is proven in this paper to be equal to 30% of the required NPS PN transmit energy, spending less nonrenewable resource, emitting smaller CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and indicating a “green” activity. Furthermore, the localization performance and the optimal network topology for obtaining the best accuracy are mathematically derived. By assuming a positioning system with the proposed optimal network topology, the positioning accuracy is derived, and the total energy saving is reported when using NDB OFDM transmission instead of NPS PN transmission. Numerical results and experimental measurements both show a consistency with our proposed theory.
Recovery of right ventricular function after intermediate-risk pulmonary embolism: results from the multicentre Pulmonary Embolism International Trial (PEITHO)-2 (2022)

In the majority of patients with acute intermediate-risk PE switched early to a direct oral anticoagulant, echocardiographic parameters of RV function normalised within 6 days and remained normal throughout the first 6 months. Almost one in four patients, however, continued to have evidence of RV dysfunction over the long term.
A baculovirus enhancin alters the permeability of a mucosal midgut peritrophic matrix from lepidopteran larvae (1999)

The peritrophic matrix (PM) in lepidopterous larvae may function as a defensive barrier against ingested viral pathogens. PMs isolated from Trichoplusia ni and Pseudaletia unipuncta larvae, were treated with a baculovirus-encoded metalloprotease (enhancin) from Trichoplusia ni granulosis virus (TnGV) and their in vitro permeability to blue dextran and fluorescent-labelled Autographa californica nuclear polyhedrosis virus (AcMNPV) was determined using a dual chamber permeability apparatus. Incubation of T. ni PMs with 0.0, 0.5, 1.0, and 2.0mg/ml enhancin resulted in a blue dextran 2000 flux of 4.4, 6.3, 9.9, and 15.6&mgr;g/mm(2)/h, respectively. In addition, T. ni PMs treated with enhancin were found to be significantly more permeable to fluorescent-labelled AcMNPV than non-treated control PMs. The permeability of T. ni PMs treated with 3.0mg/ml enhancin was 0.017 cumulative percent crossing/mm(2)/h, whereas the permeability of the control PM was below the detectable limit. Similarly, enhancin treatment greatly increased the permeability of P. unipuncta PMs to AcMNPV. These results provide evidence that the PM from two lepidopteran species can block the passage of baculovirions across this matrix thus reducing the probability of larval infection. Furthermore, these results support the hypothesis that enhancin facilitates NPV infection of larvae by altering the permeability of the PM.
Vitrification of SRP Waste by a Slurry-fed Ceramic Melter (2001)

Savannah River Laboratory (SRL) is testing the slurry feeding of a ceramic melter as a possible method to vitrify its high-level radioactive waste. Feeding a liquid slurry requires simpler and less expensive equipment than feeding a powdered calcine. Experiments have progressed from manual feeding, to a semiautomatic system, to the present slurry-feed system, which is completely automatic. All experiments to date indicate that slurry feeding is a promising way of vitrifying waste. No safety hazards associated with feeding the slurry onto molten glass at 1150 degrees Centigrade have been observed experimentally, even when the melter chamber was purposely flooded.
Driving Guided Surface Plasmon Modes on Gold Nanowires with Perpendicularly Oriented Dielectric-Metallic Waveguide Pair (2019)

We demonstrate through simulation the excitation of guided modes on a gold waveguide by a perpendicularly oriented Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> waveguide. We can achieve 55% coupling efficiency for a 70 nm Au nanowire, and the ability for mode selection on larger Au nanowires supporting multiple modes.
A portable discrete frequency NQR explosives detection system (2019)

This paper describes realization of a prototype discrete-frequency self-contained NQR system into a small portable battery powered form-factor capable of detecting and classifying explosive ingredients such as sodium nitrite, ammonium nitrate, RDX, HMX, PETN, potassium nitrate, tetryl, urea nitrate, and glycine. Size is similar to the smallest commercially available NMR spectrometer, but includes all system components. This version uses fixed frequencies and simple pulse sequences to prove feasibility. Results include signature amplitude variation as a function of both sample mass and standoff, and detection unaffected by presence of both metallic and non-metallic clutter.
Tubular Geodesics using Oriented Flux: An ITK Implementation (2013)

This document describes an ITK implementation of an interactive method for tracing curvilinear structures. The basic tools provided in this framework are an oriented flux-based tubularity measure and a geodesic path tracer that uses the fast marching algorithm. The framework is efficient and requires minimal user interaction to trace curvilinear structures such as vessels and neurites in 2D images and 3D image stacks.
Verification test of semi-freejet method for a supersonic engine test facility (2000)

Semifree jet model test was carried out in order to acquire the data necessary for the design of a supersonic engine test facility. As a result of the test, it was verified that equivalent intake flow field is realized by the semi-freejet method. It was also confirmed that the drag under off-design condition could be reduced by controlling the bypass flow rate. Detailed design and construction of the supersonic engine test facilities were carried out on the basis of these results.
TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating SMAD2/3 transcription factors (2019)

Abstract Fibrosis is associated with almost all forms of chronic cardiac and skeletal muscle diseases. The accumulation of extracellular matrix impairs the contractility of muscle cells contributing to organ failure. Transforming growth factor beta (TGF-β) plays a pivotal role in fibrosis, activating pro-fibrotic gene programs via phosphorylation of SMAD2/3 transcription factors. However, the mechanisms that control de-phosphorylation of SMAD2/3 have remained poorly characterized. Here we show that tissue non-specific alkaline phosphatase (TNAP) is highly upregulated in hypertrophic hearts and in dystrophic skeletal muscles, and the abrogation of TGF-β signalling in TNAP positive cells reduces vascular and interstitial fibrosis. We show that TNAP co-localizes and interacts with SMAD2. TNAP inhibitor MLS-0038949 increases SMAD2/3 phosphorylation, while TNAP overexpression reduces SMAD2/3 phosphorylation and the expression of downstream fibrotic genes. Overall our data demonstrate that TNAP negatively regulates TGF-β signalling and likely represents a mechanism to limit fibrosis. Summary statement This paper shows that tissue non-specific alkaline phosphatase negatively regulates TGF-β signalling and may represent a mechanism to limit fibrosis through SMAD dephosphorylation.
Intracellular calcium in cultured rabbit oviduct epithelial cells (1996)

Oviduct fluid is the medium in which fertilization and early embryonic development occur but little is known about the ionic basis of fluid secretion or its control. Since calcium ions (Ca2+) are involved in the mechanism of secretion in other epithelia, the intracellular calcium concentration ([Ca2+]i) was measured in single, rabbit oviduct epithelial cells in primary culture using the fluorescent dye Fura-2. The resting [Ca2+]i was constant (115 nM) in cells cultured for 2-7 days. Ion substitution experiments demonstrated the presence of a Na+/Ca(2+)-exchange system in the plasma membrane, whereas influx through channels was found to have only a minor role maintaining the resting [Ca2+]i. The addition of dibutyryl cAMP (db cAMP) induced two types of response: the first was an increase in [Ca2+]i, dependent on the presence of extracellular Ca2+, and the second was a zero response. Extracellular ATP induced a transient increase in [Ca2+]i owing to the release of Ca2+ from intracellular stores and Ca2+ entering the cell across the plasma membrane. It is proposed that these effects may be due to the presence of two types of cell in culture-the ciliated and non-ciliated (secretory type) oviduct epithelial cells.
Dynamic properties in broadband pattern masking: Comparison between monocular, binocular and dichoptic viewing conditions. (2013)

To assess how remote spatial frequency components of the mask influence the pattern masking in temporal domain, the masking effect was measured under various presentation duration (50, 100, 250 and 1000ms) in monocular, binocular and dichoptic viewing conditions. The target was a horizontal sine-wave grating with spatial frequency of 1 cpd. Three types of masks with the same fundamental spatial frequency were used: a sine-wave grating(S), a square-wave grating (Q), and a missing fundamental square-wave grating (M). The contrast of the mask was set at either 0% or 40%. A spatial four-alternative-force-choice was used to measure the target threshold. The results showed the presentation duration had no main masking effect, suggesting the masking occurs fast, at least within 50ms. Under monocular and binocular viewing conditions, the Q mask caused a stronger masking effect than the S masks and the M masks also caused significant masking. Under dichoptic viewing, on the contrary, the S masks caused stronger masking than the Q masks and masking effect also occurred in dichoptic M mask. These results suggested that the contributions of remote spatial frequencies are rapid, occurring within 50ms and differ under monocular and dichoptic viewing. Meeting abstract presented at VSS 2013
BEAM-TYPE DYNAMIC VIBRATION ABSORBER COMPRISED OF FREE-FREE BEAM. TECHNICAL NOTE (1998)

This note presents a new beam-type vibration absorber having a suppressing effect on several vibration modes of beams. An approximate tuning method of the beam-type dynamic absorber is proposed, in which application is made of the tuning conditions of an absorber in the two-degrees-of-freedom system. Numerical investigations have shown the approximate tuning method to be useful and have demonstrated the effectiveness of the beam-type dynamic vibration absorber. This new absorber will be used for the deck type of steel bridge without an intermediate sway bracing, which has a space under the deck whereby this beam-type dynamic absorber may be attached.
CTSA‐IP: A Solution to Identifying and Aggregating Intellectual Property across the NIH Clinical Translational Science Award (CTSA) Consortium of Biomédical Research Institutes (2012)

Correction for Clinical and Translational Science 2011; 5:328–331. The author list for the article provided incorrect affiliations for Mark Scheideler and Steve Dewhurst. The correct list of authors and affiliations should have appeared as follows:
Gaussian 1-2-1 Networks with Imperfect Beamforming (2020)

In this work, we study bounds on the capacity of full-duplex Gaussian 1-2-1 networks with imperfect beamforming. In particular, different from the ideal 1-2-1 network model introduced in [1], in this model beamforming patterns result in side-lobe leakage that cannot be perfectly suppressed. The 1-2-1 network model captures the directivity of mmWave network communications, where nodes communicate by pointing main-lobe "beams" at each other. We characterize the gap between the approximate capacities of the imperfect and ideal 1-2-1 models for the same channel coefficients and transmit power. We show that, under some conditions, this gap only depends on the number of nodes. Moreover, we evaluate the achievable rate of schemes that treat the resulting side-lobe leakage as noise, and show that they offer suitable solutions for implementation.
Prediction of the First Modal Frequency of Compliant Mechanisms Using the Pseudo-Rigid-Body Model (1999)

The pseudo-rigid-body modeling technique is used to simplify the nonlinear analysis of compliant mechanisms. This paper presents the first work that investigates the possibility of using the pseudo-rigid-body model to predict the first modal response of compliant mechanisms. Four different configurations of the parallel-guiding mechanism are modeled and tested, as well as two configurations of compliant straight-line mechanisms. The model predictions of the first natural frequencies were compared with experimental results for all six mechanism configurations. The model predictions are within 9 percent of the experimental results for all cases.
Energy efficient architecture for wireless geophone networks (2019)

Conventional geophysical surveys used for oil and gas exploration rely on cables to transfer seismic data from geophones to the data collection center. Although the wired geophone systems are most reliable and fast in terms of data transfer, the deployment and maintenance of such cable-based systems are costly. The alternate solution is to use a wireless system. However, these networks demand energy efficient protocols. In this work, we develop and analyze energy efficient adaptive clustering of wireless geophones (ACWG) that combines energy efficient routing of data and medium access protocol. ACWG uses data compression to achieve better performance in terms of geophone lifetime and latency. ACWG includes a distributed cluster formation technique that enables the self-organization of wireless geophones. Furthermore, a master geophone serves the cluster by performing major operations, like data compression and long-range communication. This saves communication resources and increases the life-span of geophones. Our results show that ACWG can improve the lifetime of the seismic acquisition system tremendously. Presentation Date: Tuesday, September 17, 2019 Session Start Time: 1:50 PM Presentation Time: 1:50 PM Location: 221A Presentation Type: Oral