gebhart/patrepeval huggingface dataset:
Birefringence prediction of optical media (2004)

Abstract The flow and thermally induced birefringence of injection‐compression molded optical media such as compact discs and digital video discs is predicted by applying a stress‐optical rule to the flow and thermally induced stresses, which are estimated with a viscoelastic material model integrated into a non‐isothermal compressible flow simulation. The resulting model considers flow and cooling induced molecular orientation, and the transient effect of thermal stress and pressure. Contrary to previous research for polystyrene, the validated results indicate that, for polycarbonate, the magnitude of the thermally induced birefringence is comparable to the flow induced birefringence. Simulation results of the flow and thermally induced in‐plane birefringence for compact‐disc‐recordable moldings with an optical grade of polycarbonate compared well with experimental observations at different mold and melt temperatures. Both simulation and experiments indicate that mold and melt temperatures have a significant effect on the level of birefringence; increasing mold or melt temperature significantly reduces the birefringence. Polym. Eng. Sci. 44:814–824, 2004. © 2004 Society of Plastics Engineers.
Sensory and Chemical Flavor Analyses of Tomato Genotypes Grown in Florida during Three Different Growing Seasons in Multiple Years (2015)

Thirty-eight tomato ( Solanum lycopersicum L.) genotypes were analyzed for sensory attributes “sweet,” “sour,” and “overall flavor” over 7 years, one to three seasons per year (March, June, and December) as well as for physical and chemical flavor-related attributes including color, sugars, acids, and aroma volatiles (6–7 years). Principal component analysis of the data of nine genotypes showed that for harvest season, December-harvested fruit were generally associated with more acids and sourness perception and less sugars and sweetness perception and, therefore, lower overall flavor ratings compared with June-harvested fruit. March-harvested samples were intermediate. Despite the seasonal variations, there were significant differences between genotypes for sensory perception of sweetness, sourness, and flavor, between seasons for sourness and flavor, and between years for flavor, with some interactions between genotypes, seasons, and years. In addition to sugar and acid measurements, 29 aroma volatiles were evaluated in 33 genotypes over the seasons. Eleven volatiles were found to positively correlate with flavor perception and 13 enhanced flavor along with the soluble solids/titratable acidity ratio in a two-predictor model, providing aroma targets for breeders. Among the genotypes evaluated most frequently were the Florida industry standard ‘Florida 47’ and University of Florida hybrid ‘Fla. 8153’ which was released in 2006 and is now marketed as Tasti-Lee ® . ‘Florida 47’ was almost always rated lower for sweet and overall flavor compared with ‘Fla. 8153’. On a 1–9 hedonic scale, where 1 was least sweet, sour, or flavorful and 9 was most sweet, sour, or flavorful, average scores over the 7 years were 3.8 and 5.1 for sweet and 4.1 and 5.7 for overall flavor for ‘Florida 47’ and ‘Fla. 8153’, respectively. Other genotypes related to ‘Fla. 8153’, including its parents, were also rated high for sweet and overall flavor compared with ‘Florida 47’ and other commercial cultivars grown in Florida. Correspondingly, sugar measurements were higher, while acid measurements were slightly lower for ‘Fla. 8153’ compared with ‘Florida 47’. Thirteen out of 29 aroma compounds showed differences between these two genotypes, with eight being higher in ‘Fla. 8153’ (including many fruity/floral notes) and four higher in Florida 47 (C-5 and C-6 aldehydes and alcohols giving green notes). This provides a useful chemical model for two genotypes that differ in flavor quality that can be exploited by breeders seeking to improve flavor.
Erratum for Ryu et al., Activating and Elucidating Metabolism of Complex Sugars in Yarrowia lipolytica (2016)

Volume 82, no. 4, p. 1334–1345, 2016. Page 1334, abstract, lines 7 and 8: “… a carbon source, but xylose dehydrogenase…” should read “…a carbon source, but xylitol dehydrogenase….”

Page 1334, column 1, line 29: “… mediated by a xylulose dehydrogenase…” should read “…
The preventive effect of loganin on oxidative stress-induced cellular damage in human keratinocyte HaCaT cells (2022)

Loganin is a type of iridoid glycosides isolated from Corni fructus and is known to have various pharmacological properties, but studies on its antioxidant activity are still lacking. Therefore, in this study, the preventive effect of loganin on oxidative stress-mediated cellular damage in human keratinocyte HaCaT cells was investigated. Our results show that loganin pretreatment in a non-toxic concentration range significantly improved cell survival in hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-treated HaCaT cells, which was associated with inhibition of cell cycle arrest at the G2/M phase and induction of apoptosis. H<sub>2</sub>O<sub>2</sub>-induced DNA damage and reactive oxygen species (ROS) generation were also greatly reduced in the presence of loganin. Moreover, H<sub>2</sub>O<sub>2</sub> treatment enhanced the cytoplasmic release of cytochrome c, upregulation of the Bax/Bcl-2 ratio and degradation of cleavage of poly (ADP-ribose) polymerase, whereas loganin remarkably suppressed these changes. In addition, loganin obviously attenuated H<sub>2</sub>O<sub>2</sub>-induced autophagy while inhibiting the increased accumulation of autophagosome proteins, including as microtubule-associated protein 1 light chain 3-II and Beclin-1, and p62, an autophagy substrate protein, in H<sub>2</sub>O<sub>2</sub>-treated cells. In conclusion, our current results suggests that loganin could protect HaCaT keratinocytes from H<sub>2</sub>O<sub>2</sub>-induced cellular injury by inhibiting mitochondrial dysfunction, autophagy and apoptosis. This finding indicates the applicability of loganin in the prevention and treatment of skin diseases caused by oxidative damage.
A T-type channel-calmodulin complex triggers αCaMKII activation (2017)

Calmodulin (CaM) is an important signaling molecule that regulates a vast array of cellular functions by activating second messengers involved in cell function and plasticity. Low voltage-activated calcium channels of the Cav3 family have the important role of mediating low threshold calcium influx, but were not believed to interact with CaM. We find a constitutive association between CaM and the Cav3.1 channel at rest that is lost through an activity-dependent and Cav3.1 calcium-dependent CaM dissociation. Moreover, Cav3 calcium influx is sufficient to activate αCaMKII in the cytoplasm in a manner that depends on an intact Cav3.1 C-terminus needed to support the CaM interaction. Our findings thus establish that T-type channel calcium influx invokes a novel dynamic interaction between CaM and Cav3.1 channels to trigger a signaling cascade that leads to αCaMKII activation.
Prediction Based Collaborative Trackers (PCT): A Robust and Accurate Approach Toward 3D Medical Object Tracking (2011)

Robust and fast 3D tracking of deformable objects, such as heart, is a challenging task because of the relatively low image contrast and speed requirement. Many existing 2D algorithms might not be directly applied on the 3D tracking problem. The 3D tracking performance is limited due to dramatically increased data size, landmarks ambiguity, signal drop-out or complex nonrigid deformation. In this paper, we present a robust, fast, and accurate 3D tracking algorithm: prediction based collaborative trackers (PCT). A novel one-step forward prediction is introduced to generate the motion prior using motion manifold learning. Collaborative trackers are introduced to achieve both temporal consistency and failure recovery. Compared with tracking by detection and 3D optical flow, PCT provides the best results. The new tracking algorithm is completely automatic and computationally efficient. It requires less than 1.5 s to process a 3D volume which contains millions of voxels. In order to demonstrate the generality of PCT, the tracker is fully tested on three large clinical datasets for three 3D heart tracking problems with two different imaging modalities: endocardium tracking of the left ventricle (67 sequences, 1134 3D volumetric echocardiography data), dense tracking in the myocardial regions between the epicardium and endocardium of the left ventricle (503 sequences, roughly 9000 3D volumetric echocardiography data), and whole heart four chambers tracking (20 sequences, 200 cardiac 3D volumetric CT data). Our datasets are much larger than most studies reported in the literature and we achieve very accurate tracking results compared with human experts' annotations and recent literature.
SURFACE PLASMON THZ RESONATORS FOR SECURITY APPLICATIONS (2009)

This paper investigates the use of surface plasmonic effect in slit resonators for sensing and imaging in the terahertz regime. The transmittance of electromagnetic (EM) waves through a narrow aperture becomes negligible when the aperture size becomes much smaller than the wavelength. However, with the resonant excitation of charge density waves in the metal/air interface, called the surface plasmons, an extraordinary transmittance has been observed through such apertures. Using slit resonators of 50 to 100 μm width, we have demonstrated enhanced transmission of THz radiation through the slits. The ability to concentrate the EM radiation through a sub‐wavelength aperture bodes well for detection of chemical or biological materials with high sensitivity or for super‐resolution imaging of materials for NDE. We present results of using a slit resonator for chemical detection and for super‐resolution imaging of materials for NDE.
Materia�y do produkcji geotekstyli�w meandrycznych przeznaczonych do ochrony gruntu przed erozj� powierzchniow� (2015)

Wydawnictwo SIGMA-NOT wydaje czasopisma fachowe informujące swoich czytelników o najnowszych osiągnięciach naukowych i nowoczesnych rozwiązaniach technicznych w Polsce i na świecie, popularyzuje problemy techniczne oraz poszerza wiedzę i kulturę techniczną.
15-µm-pitch Cu/Au interconnections relied on self-aligned low-temperature thermosonic flip-chip bonding technique for advanced chip stacking applications (2014)

In this paper, we report the development of reliable fine-pitch micro bump interconnections that used a high-precision room-temperature bonding approach. The accuracy of the bonding process is improved by modifying conventional bump/planar-bonding-pad interconnections to form self-aligned micro bumps/truncated inverted pyramid (TIP) bonding pads, i.e., misalignment self-correction elements (MSCEs). Thermosonic flip-chip bonding (FCB) is utilized to form reliable bonds between these MSCEs at acceptable low temperatures. By applying the proposed bonding approach, the demonstration of fine-pitch Cu bump to Au bonding pad interconnects chip stacking has been realized. Microstructure analyses reveal that 15-µm-pitch micro bump joints are fabricated at room temperature.
Eye-Hand Coordination Training for Sports with Mid-air VR (2020)

A relatively recent application area for Virtual Reality (VR) systems is sports training and user performance assessment. One of these applications is eye-hand coordination training systems (EHCTSs). Previous research identified that VR-based training systems have great potential for EHCTSs. While previous work investigated 3D targets on a 2D plane, here we aim to study full 3D movements and extend the application of throughput analysis to EHCTSs. We conducted two user studies to investigate how user performance is affected by different target arrangements, feedback conditions, and handedness in VR-based EHCTSs. In the first study, we explored handedness as well as vertical and horizontal target arrangements, and showed that user performance increases with the dominant hand and a vertical target plane. In the second study, we investigated different combinations of visual and haptic feedback and how they affect user performance with different target and cursor sizes. Results illustrate that haptic feedback did not increase user performance when it is added to visual feedback. Our results inform the creation of better EHCTSs with mid-air VR systems.
Solution-grown crystals for neutron radiation detectors, and methods of solution growth (2023)

A method according to one embodiment includes growing an organic crystal from solution, the organic crystal exhibiting a signal response signature for neutrons from a radioactive source. A system according to one embodiment includes an organic crystal having physical characteristics of formation from solution, the organic crystal exhibiting a signal response signature for neutrons from a radioactive source; and a photodetector for detecting the signal response of the organic crystal. A method according to another embodiment includes growing an organic crystal from solution, the organic crystal being large enough to exhibit a detectable signal response signature for neutrons from a radioactive source. An organic crystal according to another embodiment includes an organic crystal having physical characteristics of formation from solution, the organic crystal exhibiting a signal response signature for neutrons from a radioactive source, wherein the organic crystal has a length of greater than about 1 mm in one dimension.
Should the knowledge gained from the Frequent Hemodialysis Network (FHN) trials change dialysis practice? (2011)

Salt restriction, improved volume control, and better phosphate control might prove to be important for better treatment of patients on hemodialysis. Additional analyses will provide further insight and implications for clinical practice.
Analysis of a correlation between the BRAF V600E mutation and abnormal DNA mismatch repair in patients with sporadic endometrial cancer (2009)

Point mutations of KRAS and BRAF genes are thought to be important in carcinogenesis of colon cancer. In particular, gene instability caused by decreased expression of the hMLH1 gene, a DNA mismatch repair (MMR) gene, may be linked to the activating BRAF V600E point mutation in sporadic colon cancer. However, a consensus has not been established regarding the correlation between point mutations of KRAS or BRAF and carcinogenesis in patients with endometrial cancer, which is closely related to colon cancer. Therefore, we analyzed aberrant hypermethylation of the hMLH1 gene, microsatellite instability (MSI), and point mutations of KRAS and BRAF in 44 samples of sporadic endo-metrial cancer, with the aim of examining the mechanism of carcinogenesis in patients with endometrial cancer. Aberrant hMLH1 hypermethylation was found in 17 of the 44 cases (38.6%) and showed a significant positive correlation with MSI (p=0.02). This suggests that an abnormal MMR mechanism plays an important role in carcinogenesis of sporadic endometrial cancer. Point mutation of KRAS was found in 6 of the 44 cases (13.6%), but no BRAF V600E mutation was detected. These data suggest that the BRAF V600E mutation is not the target gene for abnormal MMR in carcinogenesis in patients with sporadic endometrial cancer, unlike in colon cancer. This is supported by the relatively few previous reports indicating a correlation between endometrial cancer and the BRAF V600E mutation. Identification of new candidates for the target gene for abnormal MMR in endometrial cancer requires further work.
Concurrent C (1986)

Concurrent programming is becoming increasingly important because multicomputers, particularly networks of microprocessors, are rapidly becoming attractive alternatives to traditional maxicomputers. Effective use of such network computers requires that programs be written with components that can be executed in parallel. The C programming language does not have concurrent programming facilities. Our objective is to enhance C so that it can be used to write concurrent programs that can run efficiently on both single computers and multicomputers. Our concurrent programming extensions to C are based on the rendezvous concept. These extensions include mechanisms for the declaration and creation of processes, for process synchronization and interaction, and for process termination and abortion. We give a rationale for our decisions and compare Concurrent C extensions with the concurrent programming facilities in Ada. Concurrent C has been implemented on the UNIX system running on a single processor. A distributed version of Concurrent C is being implemented.
Efectividad clínica a tres años de cuatro sistemas de adhesión dentinarios de grabado total en lesiones cervicales (1997)

Se llevo a cabo un estudio clinico de seguimiento a 3 anos de dos sistemas de adhesion de grabado total experimentales de Bayer y dos sistemas de grabado total comercializados, Clearfil Liner Bond System y Scotch-bond Multi-Purpose, para evaluar su efectividad clinica en lesiones cervicales de clase V. Se restauraron 420 lesiones de abrasion-erosion empleando los 4 sistemas de adhesion. Se disponia de dos disenos cavitarios experimentales, en los que los margenes de esmalte podian o no biselar y grabarse con acido. Clearfil Liner Bond System y Scotch-bond Multi-Purpose demostraron altas tasas de retencion en ambos tipos de diseno de cavidad a los 3 anos. Los dos sistemas experimentales de Bayer obtuvieron tasas de retencion muy inferiores en ambos disenos de cavidad a los 3 anos. Ninguno de los sistemas garantizo margenes libres de microfiltracion a largo plazo. El numero despues de 3 anos de alteraciones de color superficiales localizadas marginalmente se observo en Clearfil Liner Bond System seguido de Scotch-bond Multi-Purposey de los dos sistemas experimentales. Se registraron pequenos defectos marginales en el margen dentinario cervical u esmalte incisal. La retencion de Clearfil Liner Bond System y Scotch-bond Multi-Purpose parece que ha mejorado claramente frente a sistemas previos, aunque el sellado marginal sigue siendo problematico. Los dos sistemas Bayer fueron clasificados como clinicamente inaceptables.
(Quintessence Int 1996; 27: 775-784)
The genetic structure of the Turkish population reveals high levels of variation and admixture (2021)

The construction of population-based variomes has contributed substantially to our understanding of the genetic basis of human inherited disease. Here, we investigated the genetic structure of Turkey from 3,362 unrelated subjects whose whole exomes (<i>n</i> = 2,589) or whole genomes (<i>n</i> = 773) were sequenced to generate a Turkish (TR) Variome that should serve to facilitate disease gene discovery in Turkey. Consistent with the history of present-day Turkey as a crossroads between Europe and Asia, we found extensive admixture between Balkan, Caucasus, Middle Eastern, and European populations with a closer genetic relationship of the TR population to Europeans than hitherto appreciated. We determined that 50% of TR individuals had high inbreeding coefficients (≥0.0156) with runs of homozygosity longer than 4 Mb being found exclusively in the TR population when compared to 1000 Genomes Project populations. We also found that 28% of exome and 49% of genome variants in the very rare range (allele frequency < 0.005) are unique to the modern TR population. We annotated these variants based on their functional consequences to establish a TR Variome containing alleles of potential medical relevance, a repository of homozygous loss-of-function variants and a TR reference panel for genotype imputation using high-quality haplotypes, to facilitate genome-wide association studies. In addition to providing information on the genetic structure of the modern TR population, these data provide an invaluable resource for future studies to identify variants that are associated with specific phenotypes as well as establishing the phenotypic consequences of mutations in specific genes.
The Transfer of Diazepam Across the Placenta During Labour (1973)

The transfer of diazepam through the placenta during labour was studied by the gas chromatographic method developed by us using a Ni 63 ‐electron capture detector. 10 mg of diazepam was given intramuscularly to 37 patients during the first stage of labour 5‐401 min before delivery, after which blood samples were immediately collected from the umbilical cord and the maternal vein. Diazepam was found in all the plasma samples with very great individual variation in the concentrations. In one particular case, in which the delivery took place 5 minutes after the diazepam injection, the corresponding diazepam concentrations in the cord plasma and in the maternal plasma were 506 ng/ml and 504 ng/ml. In 31 cord plasma samples collected 26‐401 min after the diazepam injection the mean diazepam concentration was 70 ng/ml, and in the maternal plasma was 38 ng/ml. The average foetal/maternal concentration ratio during the same time period was 2.0 and in the whole series 1.8. Neither the diazepam concentrations in the cord plasma nor the foetal/maternal ratios of the concentrations had any significant influence on the Apgar scores of the newborns. The cause of the diazepam accumulation in the foetal circulation is unclear. The better binding of diazepam with the foetal plasma proteins is discussed. The importance of individual drug doses to parturients according to their weight is emphasized.
Milk Allergen Micro-Array (MAMA) for Refined Detection of Cow’s-Milk-Specific IgE Sensitization (2023)

The use of MAMA allows for the detection, using only a few microliters of serum, of IgE sensitization to multiple cow's milk allergens and allergen-derived peptides in cow-milk-allergic children with cow-milk-related anaphylaxis.
DVS for On-Chip Bus Designs Based on Timing Error Correction (2005)

On-chip buses are typically designed to meet performance constraints for worst-case conditions, including process corner, temperature, IR-drop, and neighboring net switching pattern. This can result in significant performance slack at more typical operating conditions. We propose a dynamic voltage scaling (DVS) technique for buses, based on a double sampling latch which can detect and correct for delay errors without the need for retransmission. The proposed approach recovers the available slack at non-worst-case operating points through more aggressive voltage scaling and track changing conditions by monitoring the error recovery rate. Voltage margins needed in traditional designs to accommodate worst-case performance conditions are therefore eliminated, resulting in a significant improvement in energy efficiency. The approach was implemented for a 6 mm memory read bus operating at 1.5 GHz (0.13 /spl mu/m technology node) and was simulated for a number of benchmark programs. Even at the worst-case process and environment conditions, energy gains of up to 17% are achieved, with error recovery rates under 2.3%. At more typical process and environment conditions, energy gains range from 35% to 45%, with a performance degradation under 2%. An analysis of optimum interconnect architectures for maximizing energy gains with this approach shows that the proposed approach performs well with technology scaling.
Information processing with nonlinear optical two-dimensional feedback systems (1999)

Here we discuss new potential applications in parallel image processing and adaptive optics for nonlinear spatio-temporal processes occurring in optical (opto-electronic) nonlinear two-dimensional feedback systems.