gebhart/patrepeval huggingface dataset:
De novo hepatitis b prophylaxis with hepatitis B virus vaccine and hepatitis B immunoglobulin in pediatric recipients of core antibody–positive livers (2015)

The use of hepatitis B core antibody-positive (HBcAb+) grafts for liver transplantation (LT) has the potential to safely expand the donor pool, as long as proper prophylaxis against de novo hepatitis B (DNHB) is employed. The aim of this study was to characterize the longterm outcome of pediatric LT recipients of HBcAb + liver grafts under a prophylaxis regimen against DNHB using hepatitis B virus (HBV) vaccine and hepatitis B immunoglobulin (HBIG). From June 1996 to February 2013, 49 patients receiving pediatric LT at our center were from HBcAb + donors. Forty-one patients who received DNHB prophylaxis according to our protocol were included in this analysis. Our DNHB prophylaxis protocol consists of HBV vaccine intramuscular injections given intermittently to maintain anti-hepatitis B surface antibody (HBsAb) titers above 100 IU/L. HBIG was also used during the first posttransplant year with a target anti-HBsAb titer level above 200 IU/L. There were 19 boys and 22 girls. Median age was 1.0 year (range, 4 months to 16 years). Median follow-up time was 66 months after transplant. Median annual number of HBV vaccine injections was 0.8 per year (range, 0-1.8 per year). Four patients did not require any HBV vaccine injections during follow-up. One patient with DNHB was encountered during the follow-up period (1/41, 2.4%). DNHB was diagnosed at 3.5 years after transplant, when hepatitis B surface antigen was positive upon routine follow-up serologic testing. Anti-HBsAb titer was 101.5 IU/L at the time. No grafts were lost because of DNHB-related events. Overall survival of the 41 recipients of HBcAb + grafts who received DNHB prophylaxis was 92.3% at 10 years after transplant. In conclusion, longterm prophylaxis against DNHB with HBV vaccine in pediatric LT recipients of HBcAb + grafts was safe and effective in terms of DNHB incidence as well as graft and patient survival.
Detection of Increased Upper Airway Resistance During Overnight Polysomnography (2005)

To examine the utility of four methods used to detect increased upper airway resistance leading to arousal from sleep. Ten overnight sleep studies were conducted on normal subjects who reported increased snoring and/or witnessed apneas following alcohol ingestion. Alcohol was used to increase upper airway resistance in these normal subjects before overnight polysomnography. Four methods to detect the presence of increased upper airway resistance were used: esophageal pressure manometry; respiratory inductive plethysmography; a piezoelectrically treated stretch sensor adhered to the supraclavicular fossa; nasal flow measured with oxygen cannula and differential pressure transducer. Private Sleep Laboratory ten normal, healthy volunteers (5 male, 5 female). Alcohol ingestion as red wine (14% alcohol), 180-540mL one to two hours before overnight polysomnography. Esophageal catheterisation. Two hundred twenty-seven electroen-cephalogram arousals were preceded by inspiratory flow limitation and/or increased respiratory effort. Flattening of the nasal flow profile preceded all 227 arousals. In contrast, only 40% of arousals were preceded by an increase in the size of the stretch sensor signal, 22% by more-negative deflection of the esophageal pressure signal and 21% by increase in the signal size of respiratory inductance plethysmography. These findings indicate that the most reliable method of detecting increased upper airway resistance leading to arousal from sleep is the nasal cannula/pressure transducer method and suggest that many arousals induced by increased upper airway resistance may be caused by mechanoreceptor afferents.
Contribution à l'étude du système quinaire Ca++ NH+4 H+ NO−3 PO−−−4 H2O. XVI. Le système quaternaire Ca++ H+ NO−3 PO−−−4 H2O à 500 (1956)

Abstract 1. Nous avons établi le diagramme de solubilité du système ternaire Ca ++  H +  NO 3 −  H 2 O pour la température de 50°. Le diagramme se compose de deux courbes représentant respectifement des solutions saturées de nitrate de calcium trihydraté et des solutions saturées de nitrate de calcium anhydre. Les deux courbes se rencontrent en un point à 2 sels.
Towards flexible exascale stream processing system simulation (2011)

Stream processing is an important emerging computational model for performing complex operations on and across multi-source, high-volume, unpredictable dataflows. We present Flow, a platform for parallel and distributed stream processing system simulation that provides a flexible modeling environment for analyzing stream processing applications. The Flow stream processing system simulator is a high-performance, scalable simulator that automatically parallelizes chunks of the model space and incurs near-zero synchronization overhead for acyclic stream application graphs. We show promising parallel and distributed event rates exceeding 149 million events per second on a cluster with 512 processor cores.
Organotemplate-free synthesis of high-silica ferrierite zeolite induced by CDO-structure zeolite building units (2011)

We have demonstrated here for the first time that high-silica ferrierite zeolite, designated as ZJM-2, is successfully synthesized by an induction of CDO-structure zeolite building units in the absence of organic templates. The resulting ZJM-2 has good crystallinity, high surface area, similar crystals shape, only tetrahedral Al3+ species, and abundant acidic sites.
A New β-Keto Amide Synthesis (2002)

In a modification of the Wierenga-Skulnick β-ketoester synthesis, the dianions of malonic acid mono-amides were condensed with acid chlorides. Acidic workup led to decarboxylation and isolation of the corresponding β-keto amides in good-to-excellent yields. A similar procedure with cyanoacetic acid gave β-keto nitriles.
Gas Diffusion-Type Oxygen Electrode using Perovskite-Type Oxides for Rechargeable Metal-Air Batteriees (1993)

As meta1-air batteries have high energy(lensities they are attractive as a power source of electric vehicles1)Howeverone has to overcome various difnculties to realize practical batteries of this type
Scalable distributed inference of dynamic user interests for behavioral targeting (2011)

Historical user activity is key for building user profiles to predict the user behavior and affinities in many web applications such as targeting of online advertising, content personalization and social recommendations. User profiles are temporal, and changes in a user's activity patterns are particularly useful for improved prediction and recommendation. For instance, an increased interest in car-related web pages may well suggest that the user might be shopping for a new vehicle.In this paper we present a comprehensive statistical framework for user profiling based on topic models which is able to capture such effects in a fully \emph{unsupervised} fashion. Our method models topical interests of a user dynamically where both the user association with the topics and the topics themselves are allowed to vary over time, thus ensuring that the profiles remain current.
Post-Stall Flow Control of Sharp-Edged Wings via Unsteady Blowing (2004)

In previous publications we reported on how leading-edge oscillating miniflaps can control separated flows over sharp-edged airfoils. In this paper we extend our efforts and present results on the control of flows over such airfoils using unsteady minijets deployed along the leading edge. We developed and employed a new design of an unsteady jet actuator that can achieve a wide range of blowing frequencies, allowing the independent control of the jet amplitude. The results indicate that unsteady minijet actuation is as effective as leading-edge miniflaps. The management of separated flow generates in the average lift increases the order of 50%. The present data are compared with results obtained with large, fixed leading-edge flaps. This implies that heavy flaps and the accompanied hydraulics necessary for takeoff, landing, and maneuvering could be replaced with flow control devices.
Quantitative Whole-Body Imaging of I-124-Labeled Adeno-Associated Viral Vector Biodistribution in Nonhuman Primates (2020)

A method is presented for quantitative analysis of the biodistribution of adeno-associated virus (AAV) gene transfer vectors following in vivo administration. We used iodine-124 (I-124) radiolabeling of the AAV capsid and positron emission tomography combined with compartmental modeling to quantify whole-body and organ-specific biodistribution of AAV capsids from 1 to 72 h following administration. Using intravenous (IV) and intracisternal (IC) routes of administration of AAVrh.10 and AAV9 vectors to nonhuman primates in the absence or presence of anticapsid immunity, we have identified novel insights into initial capsid biodistribution and organ-specific capsid half-life. Neither I-124-labeled AAVrh.10 nor AAV9 administered intravenously was detected at significant levels in the brain relative to the administered vector dose. Approximately 50% of the intravenously administered labeled capsids were dispersed throughout the body, independent of the liver, heart, and spleen. When administered by the IC route, the labeled capsid had a half-life of ∼10 h in the cerebral spinal fluid (CSF), suggesting that by this route, the CSF serves as a source with slow diffusion into the brain. For both IV and IC administration, there was significant influence of pre-existing anticapsid immunity on I-124-capsid biodistribution. The methodology facilitates quantitative in vivo viral vector dosimetry, which can serve as a technique for evaluation of both on- and off-target organ biodistribution, and potentially accelerate gene therapy development through rapid prototyping of novel vector designs.
Modified Fresnel computer-generated hologram directly recorded by multiple-viewpoint projections (2008)

An efficient method for obtaining modified Fresnel holograms of real existing three-dimensional (3-D) scenes illuminated by incoherent white light is presented. To calculate the hologram, the method uses multiple-viewpoint projections of the 3-D scene. However, contrary to other similar methods, this one is able to calculate the Fresnel hologram of the 3-D scene directly rather than calculating a Fourier hologram first. This significantly decreases the amount of calculations needed to obtain the hologram and also reduces the reconstruction errors. The proposed method is first mathematically introduced and then demonstrated by both simulations and experiments.
Non-destructive determination of the density distribution of polymer foam models with THz-pulses (2010)

A study of density and glue distributions in polymer foam models for lost foam casting processes is reported. THz-pulse measurements were compared with destructive measurements according to the principle of buoyancy-floating method to guarantee high quality standards in lost foam casting processes.
Innate production of Th2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells (89.11) (2010)

Abstract Innate immune responses are important in combating various microbes during the early phases of infection. NK cells are innate lymphocytes that, unlike T and B lymphocytes, do not express antigen receptors but rapidly exhibit cytotoxic activities against virus-infected cells and produce various cytokines. Here we report a new type of innate lymphocyte present in a novel lymphoid structure associated with adipose tissues in the peritoneal cavity. These cells do not express lineage (Lin) markers but do express c-Kit, Sca-1, IL7R and IL33R. Similar lymphoid clusters were found in both human and mouse mesentery and we term this tissue ‘FALC’ (fat-associated lymphoid cluster). FALC Lin-c-Kit+Sca-1+ cells are distinct from lymphoid progenitors and lymphoid tissue inducer cells. These cells proliferate in response to IL2 and produce large amounts of Th2 cytokines such as IL5, IL6 and IL13. IL5 and IL6 regulate B-cell antibody production and self-renewal of B1 cells. Indeed, FALC Lin-c-Kit+Sca-1+ cells support the self-renewal of B1 cells and enhance IgA production. After helminth infection and in response to IL33, FALC Lin-c-Kit+Sca-1+ cells produce large amounts of IL13, which leads to goblet cell hyperplasia—a critical step for helminth expulsion. In mice devoid of FALC Lin-c-Kit+Sca-1+ cells, such goblet cell hyperplasia was not induced. Thus, FALC Lin-c-Kit+Sca-1+ cells are Th2-type innate lymphocytes, and we propose that these cells be called ‘natural helper cells’.
Highly Luminescent π‐Conjugated Terpyridine Derivatives Exhibiting Thermally Activated Delayed Fluorescence (2016)

Typically, luminescent π-conjugated 2,2':6',2''-terpyridine (tpy) derivatives are versatile components for tridentate metal ligands, supramolecular materials, two-photon absorption bioimaging probes, fluorescent ion sensors, and organic light-emitting devices. However, a limited number of luminescent tpy materials, other than metal complexes, have been reported. This study introduces a series of π-conjugated tpy derivatives that exhibit strong thermally activated delayed fluorescence (TADF). We have observed that a blue tpy emitter outperforms conventional fluorescent emitters. Additionally, a green tpy emitter has exhibited a performance that is almost comparable to that of its green phosphorescent counterparts, realizing an external quantum efficiency close to 25 % and a power efficiency exceeding 80 lm W<sup>-1</sup> with an exceptionally low efficiency roll-off. This study demonstrates the first example of highly luminescent tpy-based TADF emitters.
Genetics of Carney Triad: Recurrent Losses at Chromosome 1 but Lack of Germline Mutations in Genes Associated with Paragangliomas and Gastrointestinal Stromal Tumors (2007)

We conclude that CT is not due to SDH-inactivating or KIT- and PDGFRA-activating mutations. GISTs and PGLs in CT are associated with chromosome 1 and other changes that appear to participate in tumor progression and point to their common genetic cause.
Genetic assessment of safflower (Carthamus tinctorius L.) collection with microsatellite markers acquired via pyrosequencing method (2013)

A genetic evaluation of safflower germplasm collections derived from different geographical regions and countries will provide useful information for sustainable conservation and the utilization of genetic diversity. However, the molecular marker information is limited for evaluation of genetic diversity of safflower germplasm. In this study, we acquired 509 putative genomic SSR markers for sufficient genome coverage using next-generation sequencing methods and characterized thirty polymorphic SSRs in safflower collection composed of 100 diverse accessions. The average allele number and expected heterozygosity were 2.8 and 0.386, respectively. Analysis of population structure and phylogeny based on thirty SSR profiles revealed genetic admixture between geographical regions contrary to genetic clustering. However, the accessions from Korea were genetically conserved in distinctive groups in contrast to other safflower gene pool. In conclusion, these new genomic SSRs will facilitate valuable studies to clarify genetic relationships as well as conduct population structure analyses, genetic map construction and association analysis for safflower.
Effective treatment of B16 melanoma by direct delivery of bleomycin using electrochemotherapy (1997)

Electrochemotherapy (ECT), chemotherapy administered in combination with electric fields, has the potential to be an effective localized treatment for cutaneous malignancies. Bleomycin's cytotoxicity was enhanced by exposing tumour cells to electrical fields following intravenous injection of the chemotherapeutic agent. Two issues associated with this procedure are the existence of a narrow but optimal time-window for effective treatment and the fact that a systemic drug dose is administered for a localized therapy. In order to address these issues, a study was initiated to examine the effectiveness of administering bleomycin by intratumoural injection. A dose-response relationship for intratumoural injection was determined. In addition, the minimal effective field strength necessary for ECT was established. Results of this study indicated drastic reductions in tumour volume for ECT-treated groups. In addition, ECT-treated groups showed increased survival over control groups. The minimum effective dose for the ECT intratumour bleomycin group was 0.025 units. The minimum effective field strength was found to be 1250 V/cm. The results demonstrate that intratumoural injection of bleomycin in combination with electric pulses is effective, and this information will be used to initiate clinical trials.
31:3 Judder‐Induced Edge Flicker at Zero Spatial Contrast (2003)

Abstract Judder is a motion artifact that degrades the quality of video imagery. Smooth motion appears jerky and can appear to flicker along the leading and trailing edge of the moving object. In a previous paper (1) we demonstrated that the strength of the edge flicker signal depended upon the brightness of the scene and the contrast of the moving object relative to the background. Reducing the contrast between foreground and background reduced the flicker signal. In this report, we show that the contrast signal required for judder‐induced edge flicker is due to temporal contrast and not simply to spatial contrast. Bars made of random dots of the same dot density as the background exhibit edge flicker when moved at sufficient rate.
Narrow-Polydispersity Diblock and Triblock Copolymers of Alkyl Acrylates by a “Living” Stable Free Radical Polymerization (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTNarrow-Polydispersity Diblock and Triblock Copolymers of Alkyl Acrylates by a "Living" Stable Free Radical PolymerizationNancy A. Listigovers, Michael K. Georges, Peter G. Odell, and Barkev KeoshkerianView Author Information Xerox Research Centre of Canada, 2660 Speakman Drive, Mississauga, Ontario, Canada L5K 2L1 Cite this: Macromolecules 1996, 29, 27, 8992–8993Publication Date (Web):December 30, 1996Publication History Received8 August 1996Revised8 November 1996Published online30 December 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/ma961189vhttps://doi.org/10.1021/ma961189vrapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views1023Altmetric-Citations103LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Copolymerization,Copolymers,Free radicals,Monomers,Organic compounds Get e-Alerts
UV photolysis of quinoline in interstellar ice analogs (2006)

Abstract— The polycyclic aromatic nitrogen heterocycle (PANH) quinoline (C9H7N) was frozen at 20 K in interstellar ice analogs containing either pure water or water mixed with methanol or methane and exposed to ultraviolet (UV) radiation. Upon warming, the photolysis products were analyzed by high-performance liquid chromatography and nanoscale liquid chromatography-electrospray ionization mass spectrometry. A suite of hydroxyquinolines, which were formed by the addition of oxygen atoms to quinoline, was observed as the primary product in all the ices. Quinoline N oxide was not formed, but five hydroxyquinoline isomers were produced with no clear dominance of one isomer. Reduction products, formed by hydrogen atom addition, were also created. Ices created at 20 K with H2O: quinoline ratios of 10:1 to 100:1 showed similar product distributions to those at 122 K, with no apparent temperature or concentration dependence. Increasing the UV dose led to a decrease in overall yield, indicating that quinoline and its products may be photo-destroyed. Methylquinolines were formed upon photolysis of the methanol- and methane-containing ices. In addition, possible methoxyquinolines or quinoline methylene alcohols were formed in the methanol-containing ice, while methylhydroxyquinolines were created in the methane-containing ice. This work indicates that oxidation of PANHs could occur in icy extraterrestrial environments and suggests that a search for such compounds in carbonaceous meteorites could illuminate the possible link between interstellar ice chemistry and meteoritic organics. Given the importance of oxidized and alkylated PANHs to biochemistry, the formation and delivery of such molecules to the early Earth may have played a role in the origin and evolution of life.
Summary of the Dynamo '00 panel discussion (Panel Session) (2000)

No abstract available.
Formal Total Synthesis of the Polyketide Macrolactone Narbonolide (2005)

[reaction: see text] An improved synthesis of (3S)-3-dihydronarbonolide is reported that constitutes a formal total synthesis of the 14-membered macrolactone antibiotic narbonolide. The key step was an intramolecular Nozaki-Hiyama-Kishi coupling to accomplish macrocyclization in improved yield. The high level of convergence will also allow us to rapidly synthesize narbonolide analogues for the study of enzymes in the pikromycin biosynthetic pathway.
Communication-Efficient Cooperative Contextual Bandit and Its Application to Wi-Fi BSS Selection (2020)

In this study, we extended a contextual bandit algorithm, LinUCB, to facilitate cooperative learning of an optimal strategy with intermittent information sharing. We then applied the algorithm to a Wi-Fi basic service set (BSS) selection problem. The BSS selection problem, in which a mobile user selects a BSS that provides maximal throughput based on information observed, still remains a topic of debate. Reinforcement learning, specifically the multi-armed bandit algorithm, enables mobile users to learn an optimal strategy for selecting a good BSS in their environments. This paper proposes a cooperative contextual bandit algorithm, called Cooperative LinUCB (CoopLinUCB), to address the BSS selection problem. Conventional cooperative bandit algorithms require to share experiences such as context and payoffs for every action, and the information sharing increases communication costs. The proposed algorithm enables mobile users to learn strategies using a limited amount of information that is shared intermittently. The learned strategies are then guaranteed to be equivalent to the strategies that are updated using user experience information. Simulation evaluation based on measured throughput and received signal strength indication fingerprint demonstrates that CoopLinUCB-based BSS selection learns a BSS selection strategy faster and reduces the cumulative regret compared to BSS selection without cooperation.