gebhart/patrepeval huggingface dataset:
REVISION FEMORAL STEM WITH A LONG LOCKED TOTAL PROSTHESIS AND HYDROXYAPATITE COATING: 33 CASES (2008)

Purpose of the study: The objective of this retrospective analysis was to examine the functional and radiographic results of 33 resvisions for femoral implants using a long locked stem inserted without cement and coated with hydroxyapatite. Material and methods: Mean follow-up was two years for 33 patient who underwent revison total hip arthroplasty (rTHA) with implantation of a press-fit long locked hydroxyapatite coated femoral stem (Aura or Linea) between 2000 and 2004. The explanted prosthesis was cemented in 23 cases. The reason for revision was femoral loosentng for 60%, femoral fracture for five pateints, and infection for two. According to the SOFCOT 1999 criteria, ten patients had bone defects score grade III or IV. Femorotomy was performed in 21 cases. Patients were reviewed clinically and radiologically. Function was assessed with the Postel-Merle-d’Aubligne (PMA) score and radiographic analysis determined the quality of osteointegration of the implants and the restitution of bone stock. Results: There were six early complications (one death, one disloction with sciatic paralysis), and six late complications, mainly related to defective locking. The PMA score was less than 3 for only three patients. Twenty-six patients were satisfied or very satisfied and seven patients reported thigh pain which was generally moderate. The locking was released for five prostheses because of failure or pain (relief observed in three cases). Migration was noted in three cases, illustrating their non-integration. For 15 patients, corticalisation around the lower part of the prosthesis suggested implant mobility. This image was observed in all patients who complained of thigh pain (p=0.057). There was a significant increase in the cortical index, reflecting progression of the bone stock favoring the internal cortex. Conclusion: This type of implant has provided a solution for the difficult problems of explantation and reimplantation of THA. These prostheses provide satisfactory short-term results and a significant improvement in bone stock. There remains the problem of osteointegration of certain implants. Technical factors can contribute to improved clinical results.
Is permeation competitive (1983)

This paper examines three areas where gas separation membranes are competitive with conventional technology. Those areas are the recovery of hydrogen from ammonia purge streams, the recovery of hydrogen from hydrotreater off-gas, and the separation of carbon dioxide from hydrocarbons for enhanced oil recovery. Commercial applications of gas separation membranes so far have been successful and membrane life has exceeded expectations. Membrane costs justifiably include the recuperation of development expenses now; thus, there is a good reason that the cost will come down significantly in future years as sales volume and competition increases. The paper shows, in each of the areas listed, that membranes are on a par with alternate conventional technology.
A cognitive radio system applicable to UTRA as overlay radio system (2011)

Reconfigurability of transceivers for wireless communication systems such as UMTS/LTE, WiMAX, WLAN and GSM will become increasingly important. Therefore, a flexible and reliable software and hardware architecture based on the Software-Defined Radio (SDR) paradigm is a meaningful concept. Software-Defined Radios have paved the way towards Cognitive Radios, which are based on SDRs that additionally sense their environments, track changes, and react upon their findings. A Cognitive Radio is an autonomous unit in a communications environment that frequently exchanges information with the networks it is able to access as well as with other CRs. The artifical spectrum scarcity induced by strict regulations of available frequency spectrum resources leads to the fact that especially the frequency bands which are dedicated to cellular communications are used to full capacity while a wide part of the spectrum is nearly unused. Cognitive Radio is considered to be the enabling technology for a more efficient use of the available frequency spectrum. This contribution presents a Cognitive Radio hardware demonstration testbed in application to UTRA as overlay radio system.
Binding of [99mTc]TRODAT-1 to dopamine transporters in patients with Parkinson's disease and in healthy volunteers. (2000)

The findings indicate that Parkinson's disease can be detected with [99mTc]TRODAT by simply inspecting the images for uptake in the posterior putamen. Appropriate asymmetries seem to be visible with quantification in patients with clinically defined hemi-Parkinson's disease, even though changes in the putamen contralateral to the clinically unaffected side in these patients appear to precede the development of symptoms.
Direct Patterning of Intrinsically Electron Beam Sensitive Polymer Brushes (2010)

The fabrication of patterned polymer brushes has attracted considerable attention as these structures can be exploited in devices on the nano- and microscale. Patterning of polymer brushes is typically a complex, multistep process. We report the direct patterning of poly(methyl methacrylate) (PMMA), poly(2-hydroxyethyl methacrylate) (PHEMA), poly(isobutyl methacrylate) (PIBMA), poly(neopentyl methacrylate) (PNPMA), and poly(2,2,2-trifluoroethyl methacrylate) (PTFEMA) brushes in a single step by electron beam (e-beam) lithography, to obtain nanopatterned polymer brush surfaces. PMMA, PHEMA, PIBMA, PNPMA, and PTFEMA brushes were grown on silicon substrates via surface-initiated atom transfer radical polymerization. Surface analysis techniques including ellipsometry, contact angle goniometry, atomic force microscopy (AFM), and X-ray photoelectron spectroscopy (XPS) were used to characterize the thickness, hydrophilicity, roughness, and chemical composition of the polymer brushes. Tapping-mode AFM imaging confirmed the successful electron beam patterning of these brushes. Using this direct patterning method, highly resolved nanostructured polymer brush patterns down to 50 nm lines were obtained. This direct patterning of brushes eliminates the need for complex lithographic schemes. The sensitivity of these polymer brushes toward direct patterning with e-beam was studied and compared. The sensitivity curves indicate that the structure of the e-beam degradable methacrylate polymer has a significant effect on the sensitivity of the polymer brush toward e-beam patterning. In particular, the effect of the chemical functionality at the beta-position to the carbonyl group on the polymer brush sensitivity toward direct patterning was studied using groups of varying size and polarity.
Subcutaneous isoproterenol: a convenient rat model for early detection of myocardial necrosis. (1978)

The uptake of Tc-99m pyrophosphate was studied in rat myocardial lesions produced by a single subcutaneous injection of isoproterenol (10--50 mg/kg of body weight). The uptake in the whole heart of treated rats is directly proportional to the isoproterenol dose. The Tc-99m PPi uptake measured at various times after lesion initiation parallels the myocardial calcium concentration changes. This model is useful for screening radiopharmaceuticals, and may also be suitable for studying early uptake in myocardial infarcts.
Deficiencias en materia de ciencia, políticas y prácticas en el nexo bosque-agua (2019)

Es imperioso lograr un mayor conocimiento sobre la forma de implementar regimenes de gestion eficaces para el nexo bosque-agua.
Analysis of tumor mutation burden (TMB) in >51,000 clinical cancer patients to identify novel non-coding PMS2 promoter mutations associated with increased TMB. (2016)

9572 Background: Immunotherapies have emerged as approved treatments for melanoma and non-small cell lung cancer, and have shown promise in many other tumor types. Sensitivity to these checkpoint inhibitors is known to correlate with high TMB. Numerous somatic and germline defects can lead to high TMB, including alterations affecting the mismatch repair pathway, DNA polymerases, and cell cycle regulators. We present novel mutations in the promoter of PMS2 that are significantly associated with high TMB. Methods: Hybridization capture of 236 or 315 cancer-related genes and select introns from 19 or 28 genes commonly rearranged in cancer was performed on DNA extracted from > 51,000 clinical FFPE cancer specimens and sequenced to high, uniform coverage ( > 500x). TMB was assessed as the number of somatic coding point mutations per megabase of targeted territory. Results: TMB assessed via targeted sequencing of ~1.25Mb broadly recapitulates previous results of whole exome TMB analysis. Analysis of recurrent somatic mutations identified common mutations in the promoter of PMS2, a dimerization partner of MLH1 and integral to the DNA mismatch repair complex. Promoter mutations were found in 7.5% of melanoma specimens (n = 101/1,348) and 17% of cutaneous squamous cell carcinomas (cSCC) (n = 30/175). In both tumor types, PMS2 promoter mutations are the most significant (p < 1e-5, Mann–Whitney U test) genomic correlate of TMB. Within the melanoma population, median TMB of PMS2 promoter mutant tumors increased > 5-fold (9.5 to 53.3 mutations per Mb). PMS2 promoter mutant cSCC showed a 2-fold increase in TMB over wild type tumors (35.9 to 72.7 mutations per Mb). Conclusions: PMS2 promoter mutations extend the small set of known non-coding mutations thought to affect tumor development and highlight the power of large-scale genomic analysis to uncover novel disease mechanisms. Given recent evidence that TMB may be the most sensitive and specific predictor of immune checkpoint inhibitor efficacy in a variety of tumor types, further study of PMS2 promoter mutation as a biomarker for immunotherapy selection appears warranted.
Informed Consent for Therapy and Research in Continuous Renal Replacement Therapy: An International Survey (2006)

In the field of CRRT, stated practice, beliefs and currently accepted ethical standards vary greatly according to profession, specialty and origin. A significant disagreement between what is widely promoted to be the 'correct' approach and what is currently done is evident.
Co–Ni Layered Double Hydroxide for the Electrocatalytic Oxidation of Organic Molecules: An Approach to Lowering the Overall Cell Voltage for the Water Splitting Process (2022)

Electrocatalytic oxidation of simple organic molecules offers a promising strategy to combat the sluggish kinetics of the water oxidation reaction (WOR). The low potential requirement, inhibition of the crossover of gases, and formation of value-added products at the anode are benefits of the electrocatalytic oxidation of organic molecules. Herein, we developed cobalt-nickel-based layered double hydroxide (LDH) as a robust material for the electrocatalytic oxidation of alcohols and urea at the anode, replacing the WOR. A facile synthesis protocol to form LDHs with different ratios of Co and Ni is adapted. It demonstrates that the reactants could be efficiently oxidized to concomitant chemical products at the anode. The half-cell study shows an onset potential of 1.30 V for benzyl alcohol oxidation reaction (BAOR), 1.36 V for glycerol oxidation reaction (GOR), 1.33 V for ethanol oxidation reaction (EOR), and 1.32 V for urea oxidation reaction (UOR) compared with 1.53 V for WOR. Notably, the hybrid electrolyzer in a full-cell configuration significantly reduces the overall cell voltage at a 20 mA cm<sup>-2</sup> current density by ∼15% while coupling with the BAOR, EOR, and GOR and ∼12% with the UOR as the anodic half-cell reaction. Furthermore, the efficiency of hydrogen generation remains unhampered with the types of oxidation reactions (alcohols and urea) occurring at the anode. This work demonstrates the prospects of lowering the overall cell voltage in the case of a water electrolyzer by integrating the hydrogen evolution reaction with suitable organic molecule oxidation.
Data from PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;PHA-739358 is a small-molecule 3-aminopyrazole derivative with strong activity against Aurora kinases and cross-reactivities with some receptor tyrosine kinases relevant for cancer. PHA-739358 inhibits all Aurora kinase family members and shows a dominant Aurora B kinase inhibition–related cellular phenotype and mechanism of action in cells &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo.&lt;/i&gt; p53 status–dependent endoreduplication is observed upon treatment of cells with PHA-739358, and phosphorylation of histone H3 in Ser&lt;sup&gt;10&lt;/sup&gt; is inhibited. The compound has significant antitumor activity in different xenografts and spontaneous and transgenic animal tumor models and shows a favorable pharmacokinetic and safety profile. &lt;i&gt;In vivo&lt;/i&gt; target modulation is observed as assessed by the inhibition of the phosphorylation of histone H3, which has been validated preclinically as a candidate biomarker for the clinical phase. Pharmacokinetics/pharmacodynamics modeling was used to define drug potency and to support the prediction of active clinical doses and schedules. We conclude that PHA-739358, which is currently tested in clinical trials, has great therapeutic potential in anticancer therapy in a wide range of cancers. [Mol Cancer Ther 2007;6(12):3158–68]&lt;/p&gt;&lt;/div&gt;
Predicting Breast Tumor Response to Neoadjuvant Chemotherapy with Diffuse Optical Spectroscopic Tomography prior to Treatment (2014)

This is the first clinical evidence that DOST HbT may differentiate the two groups with predictive significance based on data acquired before NAC even begins. The study also demonstrates the potential of accelerating the validation of optimal NAC regimens through future randomized clinical trials by reducing the number of patients required and the length of time they need to be followed by using a validated imaging surrogate as an outcome measure.
Investigation of Methyl Methacrylate and Vinyl Acetate Polymerization Promoted by Al(iBu)3/2,2‘-Bipyridine and Al(iBu)3/2,2‘-Bipyridine/TEMPO Complexes (1998)

Results of methyl methacrylate (MMA) and vinyl acetate (VOAc) polymerization using the Al(iBu)3/2,2‘-bipyridine/TEMPO initiating system at room temperature failed to confirm the “living” radical mechanism reported earlier. Several species apparently propagate without control in a normal free radical process and only above a critical initiator concentration. No evidence was found for the penta- and hexacoordinated aluminum species previously suggested, but high conversion to an alkoxyamine was observed. Additionally, mixing Al(iBu)3 and BIPY promotes a variety of reactions involving alkyl and hydride transfers to the aromatic rings forming reduced BIPY products, along with a persistent organoaluminum radical. All these results illustrate that the process is considerably more complicated than postulated before. Conversely, at −78 °C, a single active species excluding the participation of TEMPO has been put in evidence, displaying some “living” characteristics. Several experiments support its anionic nature, as previously suggested by Ikeda.
ChemInform Abstract: Electron‐Donating Properties of Boratabenzene Ligands. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Noninvasive molecular imaging of radioactive tracers using optical imaging techniques (2010)

1 Objectives Radioactive molecular probes are generally imaged with nuclear imaging modalities such as single photon emission computed tomography (SPECT) and positron emission tomography (PET). Optical imaging techniques have been discovered to be able to image PET probes such as 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) in small animals recently. Here we further demonstrated that conventional optical imaging techniques could be very useful for non-invasively monitoring in vivo behaviors of a variety of radioactive tracers labeled with 18F, 131I, 90Y, etc. Methods By taking the advantages of low energy window of light (1.2-3.1 eV, 400-1000 nm) resulting from radiation, radionuclides that emit charged particles such as β+ and β- can be successfully imaged with an optical imaging instrument. Results High quality of in vivo optical images was obtained for several radioactive probes including [18F]FDG, Na18F, Na131I, 90YCl3 and a 90Y labeled peptides that specifically target tumors. Conclusions These studies should prove that radioactive tracers for optical imaging is a generalizable technique. It provides a new molecular imaging strategy and will likely have significant potential for both small animal and clinical imaging
High-throughput impedance-based cell adhesion and migration assay with single-cell resolution using CMOS microelectrode array (2018)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
Printed Indium Gallium Zinc Oxide Transistors. Self-Assembled Nanodielectric Effects on Low-Temperature Combustion Growth and Carrier Mobility (2013)

Solution-processed amorphous oxide semiconductors (AOSs) are emerging as important electronic materials for displays and transparent electronics. We report here on the fabrication, microstructure, and performance characteristics of inkjet-printed, low-temperature combustion-processed, amorphous indium gallium zinc oxide (a-IGZO) thin-film transistors (TFTs) grown on solution-processed hafnia self-assembled nanodielectrics (Hf-SANDs). TFT performance for devices processed below 300 °C includes >4× enhancement in electron mobility (μFE) on Hf-SAND versus SiO2 or ALD-HfO2 gate dielectrics, while other metrics such as subthreshold swing (SS), current on:off ratio (ION:IOFF), threshold voltage (Vth), and gate leakage current (Ig) are unchanged or enhanced. Thus, low voltage IGZO/SAND TFT operation (<2 V) is possible with ION:IOFF = 10(7), SS = 125 mV/dec, near-zero Vth, and large electron mobility, μFE(avg) = 20.6 ± 4.3 cm(2) V(-1) s(-1), μFE(max) = 50 cm(2) V(-1) s(-1). Furthermore, X-ray diffraction analysis indicates that the 300 °C IGZO combustion processing leaves the underlying Hf-SAND microstructure and capacitance intact. This work establishes the compatibility and advantages of all-solution, low-temperature fabrication of inkjet-printed, combustion-derived high-mobility IGZO TFTs integrated with self-assembled hybrid organic-inorganic nanodielectrics.
ChemInform Abstract: METALLIONEN‐KONTROLLE VON CHEMISCHEN RK. (1971)

Abstract Der Artikel gibt anhand von vielen Beispielen eine Übersicht über Reaktionen in Gegenwart von Metallionen und über Reaktionen von Substraten, die mit Metallionen verknüpft sind.
Stereochemistry of palytoxin. Part 3. C7-C51 segment (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereochemistry of palytoxin. Part 3. C7-C51 segmentH. Fujioka, W. J. Christ, J. K. Cha, J. Leder, Y. Kishi, D. Uemura, and Y. HirataCite this: J. Am. Chem. Soc. 1982, 104, 25, 7367–7369Publication Date (Print):December 1, 1982Publication History Published online1 May 2002Published inissue 1 December 1982https://pubs.acs.org/doi/10.1021/ja00389a100https://doi.org/10.1021/ja00389a100research-articleACS PublicationsRequest reuse permissionsArticle Views327Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Perovskite Solar Cells: High‐Efficiency Low‐Temperature ZnO Based Perovskite Solar Cells Based on Highly Polar, Nonwetting Self‐Assembled Molecular Layers (Adv. Energy Mater. 5/2018) (2018)

In article number 1701683, In Hwan Jung, Sung-Yeon Jang, and co-workers report the synthesis of ‘high-efficiency low-temperature processed perovskite solar cells’ by the combination of two techniques; the modification of solution-processed ZnO using a self-assembled monolayer, and the fabrication of perovskite layers by a sequential deposition method. This technique may pave the way to efficiently reducing the processing temperature of perovskite solar cells.
A frequency switchable antenna based on MEMS technology (2010)

This work presents a suitable topology of a reconfigurable microstrip patch antenna using RF-MEMS devices. The RF-MEMS devices are activated with a bias voltage applied through RF feeding port. The antenna is designed for switching between two frequency bands of 5.25 GHz and 5.6 GHz. These are the frequency bands of the IEEE 802.11a standard in Europe and in the USA. A good matching is obtained in both configurations. The antenna realized using only two lithographic steps, what significantly reduces production costs. It is important for the fabrication of an integrated antenna system on the chip (SoC).
Stomatin-Like Protein 2 Binds Cardiolipin and Regulates Mitochondrial Biogenesis and Function (2011)

Stomatin-like protein 2 (SLP-2) is a widely expressed mitochondrial inner membrane protein of unknown function. Here we show that human SLP-2 interacts with prohibitin-1 and -2 and binds to the mitochondrial membrane phospholipid cardiolipin. Upregulation of SLP-2 expression increases cardiolipin content and the formation of metabolically active mitochondrial membranes and induces mitochondrial biogenesis. In human T lymphocytes, these events correlate with increased complex I and II activities, increased intracellular ATP stores, and increased resistance to apoptosis through the intrinsic pathway, ultimately enhancing cellular responses. We propose that the function of SLP-2 is to recruit prohibitins to cardiolipin to form cardiolipin-enriched microdomains in which electron transport complexes are optimally assembled. Likely through the prohibitin functional interactome, SLP-2 then regulates mitochondrial biogenesis and function.