gebhart/patrepeval huggingface dataset:
Design and calibration of pulsed vapor generators for 2,4,6-trinitrotoluene, cyclo-1,3,5-trimethylene-2,4,6-trinitramine, and pentaerythritol tetranitrate (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDesign and calibration of pulsed vapor generators for 2,4,6-trinitrotoluene, cyclo-1,3,5-trimethylene-2,4,6-trinitramine, and pentaerythritol tetranitrateJohn P. Davies, Larry G. Blackwood, Sean G. Davis, Lorenzo D. Goodrich, and Ronald A. LarsonCite this: Anal. Chem. 1993, 65, 21, 3004–3009Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/ac00069a012https://doi.org/10.1021/ac00069a012research-articleACS PublicationsRequest reuse permissionsArticle Views173Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Consumption Coagulopathy in Miliary Tuberculosis (1969)

A 56-year-old woman required hospitalization and endotracheal intubation because of progressive respiratory distress associated with bilateral diffuse pulmonary infiltrates. Within 12 hr she developed massive bleeding from a rectal hemorrhoid. Coagulation studies were consistent with a consumption coagulopathy. Despite heparin therapy the patient died. Postmortem examination showed that the immediate cause of death was an intracerebral hemorrhage. In addition there was extensive miliary tuberculosis with early granuloma formation. Histologic sections of the lung and kidney showed fibrin thrombi surrounding areas of caseation necrosis. Extensive fibrin thrombus formation in association with massive numbers of evolving tubercles is postulated as the cause of the consumption coagulopathy in this patient.
Autonomous Inflow Control Valve for Medium-Light Oil and Its Effective Performance (2023)

Summary Many horizontal oil wells will after a time start producing unwanted fluids. Autonomous inflow control valves may help to choke these unwanted fluids and consequently improve carbon efficiency. This paper publishes new experimental data describing how an autonomous inflow control valve manages medium-light oil (6 cp), water, and gas at reservoir conditions. A further objective is to evaluate how this valve might impact well performance under various conditions. To verify the single- and multiphase flow behavior of the valve, extensive flow loop experiments were performed. Initial testing was done in a model fluid laboratory, while a more extensive test was performed at reservoir conditions (i.e., with formation water, reservoir oil, and hydrocarbon gas at the given reservoir temperature and pressure). To explore and understand the impact of this valve for various reservoir scenarios, a simple conceptual reservoir model with realistic boundary conditions was used. At various differential pressures, the single-phase oil, water, and gas rates were measured. Performance at varying water and gas fractions was measured to get an improved understanding and knowledge of multiphase flow occurring in a well. The results show clearly that the valve will choke gas and water effectively, both at single-phase and multiphase flow conditions. The reservoir and model fluid evaluations show consistent results. The valve shows roughly a monotonic decreasing total rate with decreasing oil fraction, implying that the valve will always prioritize sections with the largest oil fraction. A mathematical model match of the valve performance is possible via the 10-parameter extended autonomous inflow control device (AICD) equation that enables practical evaluation of the valve in industry-standard reservoir simulators. Various scenarios are explored with a conceptual reservoir model, and the autonomous inflow control valve shows its capacity to reduce water production and enable a more gradual and controlled increase in gas/oil ratio for most scenarios. The autonomous inflow control valve shows its largest potential to reduce unwanted fluids and increase oil recovery when used in segmented reservoirs. In cases with uncertain aquifer and/or gas cap strength, or large variation in effective permeability, the valve will make an infill well more robust as it autonomously adapts to reality, chokes unwanted fluids, and consequently enables more carbon-efficient reservoir management.
The usefulness of evaluative outcome measures in patients with multiple sclerosis (2006)

To select the most useful evaluative outcome measures for early multiple sclerosis, we included 156 recently diagnosed patients in a 3-year follow-up study, and assessed them on 23 outcome measures in the domains of disease-specific outcomes, physical functioning, mental health, social functioning and general health. A global rating scale (GRS) and the Expanded Disability Status Scale (EDSS) were used as external criteria to determine the minimally important change (MIC) for each outcome measure. Subsequently, we determined whether the outcome measures could detect their MIC reliably. From these, per domain the outcome measure that was found to be most sensitive to changes (responsive) was identified. At group level, 11 outcomes of the domains of physical functioning, mental health, social functioning and general health could reliably detect the MIC. Of these 11, the most responsive measures per domain were the Medical Outcome Study 36 Short Form sub-scale physical functioning (SF36pf), the Disability and Impact Profile (DIP) sub-scale psychological, the Rehabilitation Activities Profile sub-scale occupation (RAPocc) and the SF36 sub-scale health, respectively. Overall, the most responsive measures were the SF36pf and the RAPocc. In individual patients, none of the measures could reliably detect the MIC. In sum, in the early stages of multiple sclerosis the most useful evaluative outcome measures for research are the SF36pf (physical functioning) and the RAPocc (social functioning).
Early Response–Based Therapy Stratification Improves Survival in Adult Early Thymic Precursor Acute Lymphoblastic Leukemia: A Group for Research on Adult Acute Lymphoblastic Leukemia Study (2017)

Purpose Early thymic precursor (ETP) acute lymphoblastic leukemia (ALL) is an immunophenotypically defined subgroup of T-cell ALL (T-ALL) associated with high rates of intrinsic treatment resistance. Studies in children have shown that the negative prognostic impact of chemotherapy resistance is abrogated by the implementation of early response-based intensification strategies. Comparable data in adults are lacking. Patients and Methods We performed comprehensive clinicobiologic, genetic, and survival analyses of a large cohort of 213 adult patients with T-ALL, including 47 patients with ETP-ALL, treated in the GRAALL (Group for Research on Adult Acute Lymphoblastic Leukemia) -2003 and -2005 studies. Results Targeted next-generation sequencing revealed that the genotype of immunophenotypically defined adult T-ALL is similar to the pediatric equivalent, with high rates of mutations in factors involved in cytokine receptor and RAS signaling (62.2%), hematopoietic development (29.7%), and chemical modification of histones (48.6%). In contrast to pediatric cases, mutations in DNA methylation factor genes were also common (32.4%). We found that despite expected high levels of early bone marrow chemotherapy resistance (87%), the overall prognosis for adults with ETP-ALL treated using the GRAALL protocols was not inferior to that of the non-ETP-ALL group (5-year overall survival: ETP, 59.6%; 95% CI, 44.2% to 72.0% v non-ETP, 66.5%; 95% CI, 58.7% to 73.2%; P = 0.33) and that allogeneic stem-cell transplantation had a beneficial effect in a large proportion of patients with ETP-ALL. Conclusion Our results suggest that the use of response-based risk stratification and therapy intensification abrogates the poor prognosis of adult ETP-ALL.
The design of X-band non-constant serpentine TM/sub 01/-TE/sub 11/ mode converter with short length (2005)

In this paper, a non-constant serpentine TM/sub 01/ to TE/sub 11/ mode converter with short length for X-band high power microwave applications is presented. The mode converter is designed to operate at 10 GHz and utilize the structure of circular waveguide with an excessive curvature in order to convert efficiently between two modes. To achieve optimum design, the basic parameters are calculated by the approximation method proposed in this paper and optimized by the FIM simulator.
A translatable RNAi-driven gene therapy silences PMP22/Pmp22 genes and improves neuropathy in CMT1A mice (2022)

Charcot-Marie-Tooth disease type 1A (CMT1A), the most common inherited demyelinating peripheral neuropathy, is caused by PMP22 gene duplication. Overexpression of WT PMP22 in Schwann cells destabilizes the myelin sheath, leading to demyelination and ultimately to secondary axonal loss and disability. No treatments currently exist that modify the disease course. The most direct route to CMT1A therapy will involve reducing PMP22 to normal levels. To accomplish this, we developed a gene therapy strategy to reduce PMP22 using artificial miRNAs targeting human PMP22 and mouse Pmp22 mRNAs. Our lead therapeutic miRNA, miR871, was packaged into an adeno-associated virus 9 (AAV9) vector and delivered by lumbar intrathecal injection into C61-het mice, a model of CMT1A. AAV9-miR871 efficiently transduced Schwann cells in C61-het peripheral nerves and reduced human and mouse PMP22 mRNA and protein levels. Treatment at early and late stages of the disease significantly improved multiple functional outcome measures and nerve conduction velocities. Furthermore, myelin pathology in lumbar roots and femoral motor nerves was ameliorated. The treated mice also showed reductions in circulating biomarkers of CMT1A. Taken together, our data demonstrate that AAV9-miR871-driven silencing of PMP22 rescues a CMT1A model and provides proof of principle for treating CMT1A using a translatable gene therapy approach.
Disruption of the Non-Canonical WNT Pathway in Lung Squamous Cell Carcinoma (2008)

Disruptions of beta-catenin and the canonical Wnt pathway are well documented in cancer. However, little is known of the non-canonical branch of the Wnt pathway. In this study, we investigate the transcript level patterns of genes in the Wnt pathway in squamous cell lung cancer using reverse-transcriptase (RT)-PCR. It was found that over half of the samples examined exhibited dysregulated gene expression of multiple components of the non-canonical branch of the WNT pathway. In the cases where beta catenin (CTNNB1) was not over-expressed, we identified strong relationships of expression between wingless-type MMTV integration site family member 5A (WNT5A)/ frizzled homolog 2 (FZD2), frizzled homolog 3 (FZD3) / dishevelled 2 (DVL2), and low density lipoprotein receptor-related protein 5 (LRP5)/ secreted frizzled-related protein 4 (SFRP4). This is one of the first studies to demonstrate expression of genes in the non-canonical pathway in normal lung tissue and its disruption in lung squamous cell carcinoma. These findings suggest that the non-canonical pathway may have a more prominent role in lung cancer than previously reported.
ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function (2000)

A disintegrin and metalloproteinase (ADAM) represents a protein family possessing both metalloproteinase and disintegrin domains. ADAMTS-1, an ADAM family member cloned from cachexigenic colon adenocarcinoma, is unusual in that it contains thrombospondin type I motifs and anchors to the extracellular matrix. To elucidate the biological role of ADAMTS-1, we developed ADAMTS-1-null mice by gene targeting. Targeted disruption of the mouse ADAMTS-1 gene resulted in growth retardation with adipose tissue malformation. Impaired female fertilization accompanied by histological changes in the uterus and ovaries also resulted. Furthermore, ADAMTS-1(-/-) mice demonstrated enlarged renal calices with fibrotic changes from the ureteropelvic junction through the ureter, and abnormal adrenal medullary architecture without capillary formation. ADAMTS-1 thus appears necessary for normal growth, fertility, and organ morphology and function. Moreover, the resemblance of the renal phenotype to human ureteropelvic junction obstruction may provide a clue to the pathogenesis of this common congenital disease.
Chitinolytic Enzymes in Selected Species of Veterinary Importance (2020)

Chitinolytic enzymes are secreted into the culture medium by the epithelial insect cell line from Chironomus tentans, which was cultured essentially as described by C. Wyss. To characterize the chitinases of Lucilia cuprina, an investigation was conducted covering the determination of kinetic and some physicochemical parameters. In addition to these investigations the molecular weight patterns of chitinases from different important classes of veterinary parasites and life stages were determined. Different developmental stages of insects and tick were demonstrated to express chitinolytic enzymes of different molecular weights. Melanin binds both to the substrate chitin and to the degrading enzyme, posing the still unresolved question whether it functions as an enzyme inhibitor or simply as a physical barrier that prevents the access of chitinase to its appropriate substrate. A test system for quantitative determination of inhibitory effects on chitin-metabolizing enzymes was established.
Uplink Sub-PRB Resource Allocation for Rel-15 LTE-M (2019)

This paper describes the elements of the uplink sub-PRB resource allocation, which in Rel-15 was added to the set of functionalities LTE provides for Machine-Type Communications. The high capacity demands of machine-type services, the continuous aim for lowering the device power consumption, and the need of performing more efficient uplink transmissions at low signal-to-noise ratio (SNR) regimes, have in 3GPP LTE-M Release 15 been addressed by introducing sub-PRB transmissions over PUSCH. In principle, it refers to an uplink resource allocation with finer granularity than a 180-kHz physical resource block (i.e., allocations based on sets of less than 12 adjacent 15-kHz subcarriers). The sub-PRB feature can be used to improve the uplink transmission quality of devices placed in difficult access locations at remote distances. Besides increasing the PUSCH spectral efficiency, the sub-PRB feature offers other benefits such as lowering the code rates and decreasing the device power consumption.
Polarization-independent tunable spectral slicing filter in Ti:LiNbO_3 (2011)

A two-port polarization-independent tunable spectral slicing filter at the 1530 nm wavelength regime is presented. The design utilizes an asymmetric interferometer with a sparse index grating along its arms. The sparse grating makes it possible to select equally spaced frequency channels from an incident WDM signal and to place nulls between them to coincide with the signal comb frequency. The number of selected channels and nulls between them depends on the number of coupling regions used in the sparse grating. The free spectral range depends on the spacing between the coupling regions. The Z-transform method is used to synthesize the filter and determine the spectral response. The operation of a device with six coupling regions is demonstrated, and good agreement with theoretical predictions is obtained. A 3 dB bandwidth of ∼1 nm and thermal tuning over a range of ∼13 nm are measured.
Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates (2022)

Abstract The prevalence of the Omicron subvariant BA.2.75 is rapidly increasing in India and Nepal. In addition, BA.2.75 has been detected in at least 34 other countries and is spreading globally. However, the virological features of BA.2.75 are largely unknown. Here, we evaluated the replicative ability and pathogenicity of BA.2.75 clinical isolates in Syrian hamsters. Although we found no substantial differences in weight change among hamsters infected with BA.2, BA.5, or BA.2.75, the replicative ability of BA.2.75 in the lungs was higher than that of BA.2 and BA.5. Of note, BA.2.75 caused focal viral pneumonia in hamsters, characterized by patchy inflammation interspersed in alveolar regions, which was not observed in BA.5-infected hamsters. Moreover, in competition assays, BA.2.75 replicated better than BA.5 in the lungs of hamsters. These results suggest that BA.2.75 can cause more severe respiratory disease than BA.5 and BA.2 and should be closely monitored.
Distributed scheduling for wireless networks (2011)

We pose a network-wide scheduling problem for cellular wireless networks in which users are capable of being served by several schedulers on the downlink, though not jointly. We present a distributed algorithm, with limited communication across servers, that solves this problem optimally, in that it gives the network-wide proportional fair solution. An idealized version is presented first, in which all users are capable of being served by all schedulers and in which all the decision-making takes place among the schedulers alone. A practical version is also presented, in which users play a role in choosing their servers and servers decide how to allocate resources to the users that choose them. The practical version can achieve the same optimum as the idealized one and gives gains up to 60% in typical network deployments. This version can be implemented on any wireless technology to achieve optimal network scheduling. We have focused particularly on LTE, HSPA and 1xEV-DO and the first commercial deployment will soon occur on the 1xEV-DO system, based on the 3GPP2 standard, under the rubric of `Smart Networks.
Optically induced dynamic polarization gratings for tunable, quasi-phase matched second harmonic generation (2002)

Light interference patterns can photoexcite mobile charge and generate periodic space charge fields with periods of typically 0.1 to 100 microns in photorefractive crystals. The space charge field attains values of 0.1 to 1 kV cm/sup -1/ in ferroelectrics such as Sr/sub 0.75/Ba/sub 0.25/Nb/sub 2/O/sub 6/ (SBN:75). A fundamental question is whether these periodic space charge fields can spatially modulate the ferroelectric polarization in materials which possess a coercive field of the order of the space charge field. We present experimental evidence demonstrating that this is indeed the case in SBN:75. We observe dynamic domain gratings, which form simultaneously with the build up of the space charge field, and remnant domain gratings, which persist long after the space charge field disappears.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Induced pluripotent stem cell-derived neurons from a sporadic Alzheimer's disease donor as a model for investigating disease mechanisms (2013)

Author: Hossini, A. M. et al.; Genre: Conference Paper; Published in Print: 2013; Title: Induced pluripotent stem cell-derived neurons from a sporadic Alzheimer&apos;s disease donor as a model for investigating disease mechanisms
Automatic Voice Selection in Japanese based on Various Linguistic Information (2013)

This paper focuses on a subtask of natural language generation (NLG), voice selection, which decides whether a clause is realised in the active or passive voice according to its contextual information. Automatic voice selection is essential for realising more sophisticated MT and summarisation systems, because it impacts the readability of generated texts. However, to the best of our knowledge, the NLG community has been less concerned with explicit voice selection. In this paper, we propose an automatic voice selection model based on various linguistic information, ranging from lexical to discourse information. Our empirical evaluation using a manually annotated corpus in Japanese demonstrates that the proposed model achieved 0.758 in F-score, outperforming the two baseline models. 1
Investigation of bearing faults in three phase induction motor using wavelet de-noising with improved Wiener filtering (2020)

Bearing fault diagnosis in an induction motor, especially at nascent stage has become inevitable and captious to avoid unexpected shut down of the industrial process. Many researchers have concentrated on various monitoring techniques including vibration, temperature, chemical and current monitoring. In this paper, an improved bearing fault detection using motor current signature analysis (MCSA) has been presented. In the proposed work, the bearing fault signature is extracted from stator current using improved Wiener filter cancellation. Performance of Wiener filter is improved using two stage process. The side band effects of filter is removed using Kaiser window and the higher order noise due to filtering process is removed with wavelet de-noising technique. Different categories of bearing failures are examined with and without de-nosing using pre-fault component cancellation (noise cancellation). Moreover, fault indexing based on standard deviation (SD) and energy (E) value of noise canceled stator current is proposed. The proposed bearing fault detection topology is examined using simulations and experiments on a 2HP induction motor under different load condition.
“Central vessel sign” on 3T FLAIR* MRI for the differentiation of multiple sclerosis from migraine (2015)

Identification of CVS using FLAIR* on 3T MRI helps differentiate MS from migraine, particularly in the subcortical and deep white matter.
Two competing queues with linear costs: the μc-rule is often optimal (1984)

A state-space model is presented for a queueing system where two classes of customer compete in discrete-time for the service attention of a single server with infinite buffer capacity. The arrivals are modelled by an independent identically distributed random sequence of a general type while the service completions are generated by independent Bernoulli streams; the allocation of service attention is governed by feedback policies which are based on past decisions and buffer content histories. The cost of operation per unit time is a linear function of the queue sizes. Under the model assumptions, a fixed prioritization scheme, known as the μ c -rule, is shown to be optimal when the expected long-run average criterion and the expected discounted criterion, over both finite and infinite horizons, are used. This static prioritization of the two classes of customers is done solely on the basis of service and cost parameters. The analysis is based on the dynamic programming methodology for Markov decision processes and takes advantage of the sample-path properties of the adopted state-space model.