Immunology of Infection with the Human Immunodeficiency Virus (HIV) (1987)

Editorials1 September 1987Immunology of Infection with the Human Immunodeficiency Virus (HIV)A View from the III International Conference on AIDSSCOTT KOENIG, Ph.D., M.D., ZEDA F. ROSENBERG, Sc.DSCOTT KOENIG, Ph.D., M.D.Search for more papers by this author, ZEDA F. ROSENBERG, Sc.DSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-2-409 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe virulence of the human immunodeficiency virus (HIV) lies in its unique ability to disarm the system that provides protection against invasive pathogens completely. The virus devastates the immune system by eliminating the T4 lymphocyte, which is the key component for generating and regulating the immune response (1). The T4 lymphocytes that do survive cannot execute the functions they were programmed to perform. The macrophage, a critical element in the generation of a specific immune response, can also be infected with HIV (2) and may serve as an important viral reservoir in the infected host (3, 4). Investigators are trying...References1. FAUCIMASURGELMANNMARKHAMHAHNLANE AHEPBH. The acquired immunodeficiency syndrome: an update. Ann Intern Med. 1985;102:800-13. LinkGoogle Scholar2. GARTNERMARKOVITSMARKOVITSKAPLANGALLOPOPOVIC SPDMRM. The role of mononuclear phagocytes in HTLV-III/ LAV infection. Science. 1986;233:215-9. CrossrefMedlineGoogle Scholar3. KOENIGGENDELMANORENSTEIN SHJ. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science. 1986;233:1089-93. CrossrefMedlineGoogle Scholar4. WILEYSCHRIERNELSONLAMPERTOLDSTONE CRJPM. Cellular localization of human immunodeficiency virus infection within the brains of acquired immunodeficiency syndrome patients. Proc Natl Acad Sci USA. 1986;83:7089-93. CrossrefMedlineGoogle Scholar5. 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An AIDS-related cytotoxic autoantibody reacts with a specific antigen on stimulated CD4+ T cells. Nature. 1987;327:710-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAcquired Immune Deficiency Syndrome and the LungCorrection: Immunology of Infection with the Human Immunodeficiency Virus (HIV): A View from the III International Conference on AIDSCurrent Concepts in the Virology of Infection with Human Immunodeficiency Virus (HIV) A View from the III International Conference on AIDSJAMES A. HOXIE, M.D. 1 September 1987Volume 107, Issue 3Page: 409-412KeywordsHIVHIV infectionsImmune responseImmune systemImmunologyLymphocytesMacrophagesPathogens Issue Published: 1 September 1987 PDF DownloadLoading ...