gebhart/patrepeval huggingface dataset:
Supercritical CO2 Assisted Preparation of Supported Molybdenum Phosphide for Hydrotreating Catalysis (2017)

Abstract Many studies in literature have reported supported metal phosphides as promising hydrotreating catalysts. The synthesis of highly dispersed metal phosphide nanoparticles is usually achieved tuning various parameters such as the nature of the phosphorous precursor or the reduction protocol. In this study, the alumina supported molybdenum phosphides were prepared following a newly developed method using supercritical fluids (SCFs) technology including several elementary steps: incipient wetness impregnation and ageing, supercritical CO 2 flash‐drying, followed by hydrogen reduction. Experimental parameters allowed us modulating main characteristics of catalysts: crystallinity, reducibility, nanoparticles (NPs) mean size and size distribution. High temperature treatments (400 °C) in scCO 2 media lead to the presence of heteropolyanions unlike what is observed in conventional treatment under air. Catalytic performances in selective hydrodesulfurization of methyl‐3‐thiophene, in presence of 2,3‐dimethylbut‐2‐ene, have been assessed and were improved in terms of activity or selectivity compared to MoP and CoMoS reference catalysts, respectively.
Emerging MPEG Standards for Point Cloud Compression (2018)

Due to the increased popularity of augmented and virtual reality experiences, the interest in capturing the real world in multiple dimensions and in presenting it to users in an immersible fashion has never been higher. Distributing such representations enables users to freely navigate in multisensory 3D media experiences. Unfortunately, such representations require a large amount of data, not feasible for transmission on today's networks. Efficient compression technologies well adopted in the content chain are in high demand and are key components to democratize augmented and virtual reality applications. Moving Picture Experts Group, as one of the main standardization groups dealing with multimedia, identified the trend and started recently the process of building an open standard for compactly representing 3D point clouds, which are the 3D equivalent of the very well-known 2D pixels. This paper introduces the main developments and technical aspects of this ongoing standardization effort.
Interleukin-8 Gene Repression by Clarithromycin Is Mediated by the Activator Protein-1 Binding Site in Human Bronchial Epithelial Cells (2000)

Macrolide antibiotics are known to be effective for the treatment of chronic inflammatory airway diseases including diffuse panbronchiolitis, chronic bronchitis, and bronchial asthma. Other than having antimicrobial activities, macrolides have antiinflammatory effects, such as the inhibition of cytokine production. In the present study we investigated the effects of clarithromycin (CAM) on interleukin (IL)-8 gene expression and protein levels, using the human bronchial epithelial cell line BET-1A. Northern blot analyses showed that CAM inhibited tumor necrosis factor (TNF)-alpha-induced IL-8 gene expression in a dose- and incubation time-dependent manner. The half-life of IL-8 messenger RNA transcripts in TNF-alpha-treated BET-1A cells did not change with CAM. Transfection studies with BET-1A cells, using fusion genes composed of the 5'-flanking sequences of the IL-8 gene and a luciferase reporter gene, demonstrated potent promoter activity in a 174-bp segment (-130 to +44 bp relative to the transcription start site). This segment includes activator protein (AP)-1 and nuclear factor (NF)-kappaB-like sites, and exhibited its strongest response to TNF-alpha. TNF-alpha-induced promoter activity in this segment showed a significant repression by CAM. However, a 156-bp segment (-112 to +44 bp) that does not include an AP-1 site but includes an NF-kappaB-like site did not show a significant repression of TNF-alpha-induced promoter activity by CAM. Mutation of the AP-1 binding site abrogated the suppression by CAM of TNF-alpha-induced enhancement of luciferase activity. In accord with promoter analyses, an electrophoretic mobility shift assay showed that CAM repressed AP-1 binding in TNF-alpha-treated BET-1A cells; however, TNF-alpha induced both AP-1 and NF-kappaB binding activities in BET-1A cells. These data suggest that macrolides such as CAM repress IL-8 gene transcription mainly via the AP-1 binding site in human bronchial epithelial cells. Our findings provide a novel mechanism for the antiinflammatory function of macrolides, implicating a target for the development of new drugs for treating chronic airway inflammation.
The treatment of uterine leiomyosarcoma: clinical outcomes of 18 cases and the effectiveness of chemotherapy. (2011)

The combination of surgery and chemotherapy seems to be an acceptable treatment for uterine leiomyosarcoma. IEP may be an active regimen for this aggressive disease.
Effect of Immune Mechanisms on the Pharmacokinetics and Organ Distribution of Cryptococcal Polysaccharide (1998)

Cryptococcus neoformans is an encapsulated opportunistic fungus that can cause chronic infections accompanied by high tissue levels of capsular polysaccharide (CPS). CPS or its major component, glucuronoxylomannan (GXM), was administered to mice, and whole-body and tissue levels were measured. The role of monoclonal antibody (MAb), complement, and CD4 T cells in GXM clearance was also examined. These studies demonstrate that CPS is cleared from the blood within days but is retained in the body for weeks; that MAbs of all isotypes examined promote GXM clearance; that MAb-mediated GXM deposition in liver, but not in spleen, is Fc-dependent; that complement enhances IgM-mediated GXM sequestration in liver but not spleen; and that CD4 T cells are not necessary for serum GXM clearance. The results have important implications for the eventual use of MAbs in treatment of cryptococcosis.
Data from Small-Molecule Inhibitors of USP1 Target ID1 Degradation in Leukemic Cells (2023)

&lt;div&gt;Abstract&lt;p&gt;Inhibitor of DNA binding 1 (ID1) transcription factor is essential for the proliferation and progression of many cancer types, including leukemia. However, the ID1 protein has not yet been therapeutically targeted in leukemia. ID1 is normally polyubiquitinated and degraded by the proteasome. Recently, it has been shown that USP1, a ubiquitin-specific protease, deubiquitinates ID1 and rescues it from proteasome degradation. Inhibition of USP1 therefore offers a new avenue to target ID1 in cancer. Here, using a ubiquitin-rhodamine–based high-throughput screening, we identified small-molecule inhibitors of USP1 and investigated their therapeutic potential for leukemia. These inhibitors blocked the deubiquitinating enzyme activity of USP1 &lt;i&gt;in vitro&lt;/i&gt; in a dose-dependent manner with an IC&lt;sub&gt;50&lt;/sub&gt; in the high nanomolar range. USP1 inhibitors promoted the degradation of ID1 and, concurrently, inhibited the growth of leukemic cell lines in a dose-dependent manner. A known USP1 inhibitor, pimozide, also promoted ID1 degradation and inhibited growth of leukemic cells. In addition, the growth of primary acute myelogenous leukemia (AML) patient-derived leukemic cells was inhibited by a USP1 inhibitor. Collectively, these results indicate that the novel small-molecule inhibitors of USP1 promote ID1 degradation and are cytotoxic to leukemic cells. The identification of USP1 inhibitors therefore opens up a new approach for leukemia therapy. &lt;i&gt;Mol Cancer Ther; 12(12); 2651–62. ©2013 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Simulation of a transient heterogeneous phase transition. (1995)

A dynamic model combining molecular kinetic theory and classical nucleation theory was used to simulate the heterogeneous vapor-to-crystal phase transition in a closed vacuum chamber at low substrate temperature. The governing equations for the motes of molecules adsorbed to the substrate, the pressure in the chamber, and the number and mass of the crystals formed were simultaneously integrated. The model showed that the heterogeneous phase transition changed from one controlled by crystal growth to one controlled by heterogeneous nucleation as the condensation coefficient decreased. On the basis of the observation and the assumption for the adherence between the crystals and the substrate surface to be incomplete, the substrate temperature and the crystal surface temperature, respectively, were raised by 0.4 K and by 1 K at the onset of nucleation in the model computation. The changes in vapor pressure with elapsed time in the computed results agreed reasonably well with the experimental ones.
Ordered 2D arrays of ferromagnetic Fe/Co nanoparticle rings from a highly metallized metallopolymer precursor (2004)

Ordered 2D arrays of ferromagnetic Fe/Co alloy nanoparticle rings with diameters of 2–12 µm were fabricated via plasma etching and subsequent pyrolytic treatment of template directed self-assembled rings of a highly metallized polyferrocenylsilane metallopolymer precursor.
Glutamatergic Neurotransmission between the C1 Neurons and the Parasympathetic Preganglionic Neurons of the Dorsal Motor Nucleus of the Vagus (2013)

The C1 neurons are a nodal point for blood pressure control and other autonomic responses. Here we test whether these rostral ventrolateral medullary catecholaminergic (RVLM-CA) neurons use glutamate as a transmitter in the dorsal motor nucleus of the vagus (DMV). After injecting Cre-dependent adeno-associated virus (AAV2) DIO-Ef1α-channelrhodopsin2(ChR2)-mCherry (AAV2) into the RVLM of dopamine-β-hydroxylase Cre transgenic mice (DβH(Cre/0)), mCherry was detected exclusively in RVLM-CA neurons. Within the DMV >95% mCherry-immunoreactive(ir) axonal varicosities were tyrosine hydroxylase (TH)-ir and the same proportion were vesicular glutamate transporter 2 (VGLUT2)-ir. VGLUT2-mCherry colocalization was virtually absent when AAV2 was injected into the RVLM of DβH(Cre/0);VGLUT2(flox/flox) mice, into the caudal VLM (A1 noradrenergic neuron-rich region) of DβH(Cre/0) mice or into the raphe of ePet(Cre/0) mice. Following injection of AAV2 into RVLM of TH-Cre rats, phenylethanolamine N-methyl transferase and VGLUT2 immunoreactivities were highly colocalized in DMV within EYFP-positive or EYFP-negative axonal varicosities. Ultrastructurally, mCherry terminals from RVLM-CA neurons in DβH(Cre/0) mice made predominantly asymmetric synapses with choline acetyl-transferase-ir DMV neurons. Photostimulation of ChR2-positive axons in DβH(Cre/0) mouse brain slices produced EPSCs in 71% of tested DMV preganglionic neurons (PGNs) but no IPSCs. Photostimulation (20 Hz) activated PGNs up to 8 spikes/s (current-clamp). EPSCs were eliminated by tetrodotoxin, reinstated by 4-aminopyridine, and blocked by ionotropic glutamate receptor blockers. In conclusion, VGLUT2 is expressed by RVLM-CA (C1) neurons in rats and mice regardless of the presence of AAV2, the C1 neurons activate DMV parasympathetic PGNs monosynaptically and this connection uses glutamate as an ionotropic transmitter.
ChemInform Abstract: Synthesis and Enzymatic Evaluation of Two Conformationally Restricted Trisaccharide Analogues as Substrates for N‐ Acetylglucosaminyltransferase V. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Modular Methodology to Optimize Innovative Drivetrains (2013)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;In this paper, an integrated simulation-based methodology demonstrating feasibility and performance of several electric-hybrid concepts is developed. Several advanced tools are coupled to define the specifications of each component of the hybrid powertrain, to select the most promising hybrid architecture and finally to assess the proposed powertrain with regard to CO&lt;sub&gt;2&lt;/sub&gt; and pollutants emissions.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;Concurrent minimization of NOx and CO&lt;sub&gt;2&lt;/sub&gt; emissions enables to find the best compromise to fulfil Euro 6 standards while lowering fuel consumption. This stage consists in an iterative co-optimization of the power split strategies between the electric drive and the Diesel engine and of the engine settings (injection pressure, EGR rate, etc.). The methodology combines optimal control laws and optimization methodology based on global statistical models using single-cylinder design of experiments. After several iterations, this method allows to find the optimal NOx/CO&lt;sub&gt;2&lt;/sub&gt; trade-off curve. This enables to choose those settings and power split laws that satisfy Euro 6 standards without a NOx-dedicated aftertreatment device, or using an SCR-type aftertreatment device (with higher raw NOx emissions), while simultaneously minimizing fuel consumption.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;The proposed methodology, combined with powerful tools, facilitates the optimization and the assessment of a large diversity of innovative drivetrains.&lt;/div&gt;&lt;/div&gt;
Occupation times of random walks in confined geometries: From random trap model to diffusion-limited reactions (2007)

We consider a random walk in confined geometry, starting from a site and eventually reaching a target site. We calculate analytically the distribution of the occupation time on a third site, before reaching the target site. The obtained distribution is exact and completely explicit in the case or parallelepipedic confining domains. We discuss implications of these results in two different fields: The mean first passage time for the random trap model is computed in dimensions greater than 1 and is shown to display a nontrivial dependence with the source and target positions. The probability of reaction with a given imperfect center before being trapped by another one is also explicitly calculated, revealing a complex dependence both in geometrical and chemical parameters.
Modeling and forecasting of manufacturing variations (embedded tutorial) (2001)

Process-induced variations are an important consideration in the design of integrated circuits. Until recently, it was sufficient to model die-to-die shifts in device performance, leading to the well known worst-case modeling and design methodology [1, 2]. However, current and near-future in-tegrated circuits are large enough that device and intercon-nect parameter variations within the chip are as important as those same variations from chip to chip. This presents a new set of challenges for process modeling and characterization and for the associated design tools and method-ologies. This paper examines the sources and trends of process variability, the new challenges associated with the increase in within-die variability analysis, and proposes a modeling and simulation methodology to deal with this variability.
Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice (2020)

Pathological aggregates of tau proteins accumulate in the brains of neurodegenerative tauopathies including Alzheimer's disease and frontotemporal lobar degeneration (FTLD-tau). Although immunotherapies of these disorders against tau are emerging, it is unknown whether nasal delivery, which offers many benefits over traditional approaches to vaccine administration, is effective or not for tauopathy. Here, we developed vaccination against a secreted form of pathological tau linked to FTLD-tau using a Sendai virus (SeV) vector infectious to host nasal mucosa, a key part of the immune system. Tau vaccines given as nasal drops induced tissue tau-immunoreactive antibody production and ameliorated cognitive impairment in FTLD-tau model mice. In vivo imaging and postmortem neuropathological assays demonstrated the suppression of phosphorylated tau accumulation, neurotoxic gliosis, and neuronal loss in the hippocampus of immunized mice. These findings suggest that nasal vaccine delivery may provide a therapeutic opportunity for a broad range of populations with human tauopathy.
Unreported accidents to patients in hospital. (1994)

A study to discover the incidence of unreported patient accidents was carried out in 10 wards in a large acute hospital. There were three separate survey days, 10 weeks apart, and sources of data included patients, records and accident report books. The 574 patients who participated in the study had sustained, during their stay in hospital, 75 accidents. Of these 49 (65%) were reported (documented on an accident report form) and 26 (35%) were unreported. Multiple unreported accidents to three patients accounted for 14 of the unreported accidents. Patient responses suggested that staff knew about the unreported accidents in the majority of cases. Conclusions and recommendations from this, and the two preceding studies include improved maintenance, increased awareness of patients' views and radical change to the present reporting procedure, as ways of improving patient accident data, patient safety and care.
Bacterial Route Finding and Collective Escape in Mazes and Fractals (2020)

Bacteria which grow not on the featureless agar plates of the microbiology lab but in the real world must navigate topologies which are nontrivially complex, such as mazes or fractals. We show that chemosensitive motile E. coli can efficiently explore nontrivial mazes in times much shorter than a no-memory (Markovian) walk would predict, and can collectively escape from a fractal topology. The strategies used by the bacteria include individual power-law probability distribution function exploration, the launching of chemotactic collective waves with preferential branching at maze nodes and defeating of fractal pumping, and bet hedging in case the more risky attempts to find food fail.
<title>Pi overlapping ring systems contained in a homogeneous assay: a novel homogeneous assay for antigens</title> (1993)

A novel immunoassay, Pi overlapping ring systems contained in a homogeneous assay (PORSCHA), is described. This assay relies upon the change in fluorescent spectral properties that pyrene and its derivatives show with varying concentration. Because antibodies and other biomolecules can bind two molecules simultaneously, they can change the local concentration of the molecules that they bind. This concentration change may be detected spectrally as a change in the fluorescence emission wavelength of an appropriately labeled biomolecule. Several tests of PORSCHA have been performed which demonstrate this principle. For example: with streptavidin as the binding biomolecule and a biotin labeled pyrene derivative, the production of the excimer emitting at 470 nm is observed. Without the streptavidin present, only the monomer emitting at 378 and 390 nm is observed. The ratio of monomer to excimer provides the concentration of unlabeled biotin in the sample. Approximately 1 ng/mL of biotin may be detected with this system using a 50 (mu) l sample (2 X 10<SUP>-16</SUP> moles biotin). The principles behind PORSCHA, the results with the streptavidin/biotin system are discussed and extensions of the PORSCHA concept to antibodies as the binding partner and DNA in homogeneous assays are suggested.
Perceptual Learning Improves Visual Performance in Juvenile Amblyopia (2005)

Perceptual learning can improve visual performance in amblyopic children. The improvement can be parsed into two important factors: decreased equivalent input noise and increased efficiency. Perceptual learning techniques may add an effective new method to the armamentarium of amblyopia treatments.
ChemInform Abstract: The Molybdenum‐Mediated Tandem Pauson—Khand Reaction. High Yield Entry into [5.5.5.5]Tetracyclic Systems. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Antisense transcription as a tool to tune gene expression (2016)

A surprise that has emerged from transcriptomics is the prevalence of genomic antisense transcription, which occurs counter to gene orientation. While frequent, the roles of antisense transcription in regulation are poorly understood. We built a synthetic system in Escherichia coli to study how antisense transcription can change the expression of a gene and tune the response characteristics of a regulatory circuit. We developed a new genetic part that consists of a unidirectional terminator followed by a constitutive antisense promoter and demonstrate that this part represses gene expression proportionally to the antisense promoter strength. Chip-based oligo synthesis was applied to build a large library of 5,668 terminator-promoter combinations that was used to control the expression of three repressors (PhlF, SrpR, and TarA) in a simple genetic circuit (NOT gate). Using the library, we demonstrate that antisense promoters can be used to tune the threshold of a regulatory circuit without impacting other properties of its response function. Finally, we determined the relative contributions of antisense RNA and transcriptional interference to repressing gene expression and introduce a biophysical model to capture the impact of RNA polymerase collisions on gene repression. This work quantifies the role of antisense transcription in regulatory networks and introduces a new mode to control gene expression that has been previously overlooked in genetic engineering.
Surgically induced degenerative changes in the femorotibial joints by total medial meniscectomy in minipigs closely resemble late-stage osteoarthritis (2019)

Animal models of osteoarthritis (OA) have played a key role in understanding the etiology of OA and in the development of new therapeutic strategies. Although pigs have an advantage as an animal disease model due to their similarity to humans, there are few studies on the induction of OA in minipigs. Therefore, this study aimed to characterize disease progression of OA in total medial meniscectomy (TMM)-operated skeletally mature minipigs, up to day 180 postoperatively. There were no significant alterations in vital signs or hematological indices throughout the observation period. However, clinical manifestations of OA in the medial femoral condyles of TMM-operated minipigs were progressive, depending on postoperative duration, with respect to osteophytes formation and roughened surfaces on radiological observation, cartilage erosion under macroscopic examination, and severe cartilage defects including fibrillation, vertical fissures, and cartilage denuding on histopathological observation, with the highest score indicating latestage OA on day 180 and without indicating apparent variation between subjects. In particular, the lateral femoral condyles were also degenerated, possibly due to localization of weight-bearing from both menisci to the lateral meniscus. Therefore, TMM in minipigs is suitable for reproducible induction of degenerative changes in the femorotibial joints that closely resemble late-stage OA, and is suitable for use in further research.