gebhart/patrepeval huggingface dataset:
A phase II randomized study of telaglenastat, a glutaminase (GLS) inhibitor, versus placebo, in combination with pembrolizumab (Pembro) and chemotherapy as first-line treatment for KEAP1/NRF2-mutated non-squamous metastatic non-small cell lung cancer (mNSCLC). (2020)

TPS9627 Background: Mutational activation of the KEAP1/NRF2 pathway occurs in &gt;20% of NSCLC patients (pts). KEAP1/NRF2 activation protects tumor cells from diverse forms of oxidative stress and promotes tumor growth and survival. In pts w/ advanced NSCLC, mutation of the KEAP1/NRF2 pathway is associated w/ dramatically reduced survival and poor outcomes following standard-of-care therapy. These tumors have increased dependence on GLS-mediated conversion of glutamine to glutamate due to upregulation of NRF2 target genes involved in glutamine metabolism. Telaglenastat (CB-839), an investigational, first-in-class, potent, oral GLS inhibitor, has demonstrated preclinical activity in KEAP1/NRF2-mutated NSCLC cell lines and xenograft models. This study will evaluate the safety and efficacy of telaglenastat + standard-of-care pembro and chemotherapy as 1L therapy for KEAP1/NRF2-mutated non-squamous mNSCLC (NCT04265534). Methods: This phase II, randomized, multicenter, double-blind study will enroll ~120 pts with histologically or cytologically documented stage IV non-squamous NSCLC w/ KEAP1 or NRF2 mutation, no prior systemic therapy for mNSCLC, measurable disease (RECIST v1.1), ECOG PS 0-1, and no EGFR, ALK, ROS, or other actionable mutation w/ available approved therapy in 1L setting. KEAP1 or NRF2 mutations will be determined by next generation sequencing (NGS), and study-provided liquid biopsy NGS will be available. Pts will be randomized 1:1 to receive telaglenastat (800 mg BID PO) or placebo, in combination with pembro, carboplatin, and pemetrexed at standard doses on day 1 of each 21-day cycle. Pts will be stratified by STK11/LKB1 mutational status and M stage of cancer (M1a-b vs M1c). The study will include an initial safety run-in period (n=12; 1 cycle). Co-primary endpoints are safety and investigator-assessed progression-free survival (RECIST v1.1). Secondary endpoints include overall response rate, duration of response, overall survival, and efficacy analysis in the subgroup of pts w/ biochemical confirmation of KEAP1/NRF2 pathway activation. Findings of this novel NGS biomarker-selected study will inform the efficacy and safety profile of telaglenastat + standard-of-care chemoimmunotherapy for 1L treatment of KEAP1/NRF2-mutated, non-squamous mNSCLC. Clinical trial information: NCT04265534 .
Inversion Recovery Susceptibility Weighted Imaging With Enhanced T2 Weighting at 3 T Improves Visualization of Subpial Cortical Multiple Sclerosis Lesions (2020)

Subpial lesions are better visualized on IR-SWIET compared with other 3 T methods. A 3 T protocol combining IR-SWIET with MP2RAGE, in which leukocortical lesions are well seen, improves cortical lesion visualization over existing approaches. Therefore, IR-SWIET may enable improved MS diagnostic specificity and a better understanding of the clinical implications of cortical demyelination.
Assessment of a Siloxane Poly(urethane‐urea) Elastomer Designed for Implantable Heart Valve Leaflets (2020)

Synthetic polymer leaflets in prosthetic cardiac valves hold the potential to reduce calcification and thrombus, while improving blood flow, durability, and device economics. A recently developed siloxane poly(urethane‐urea) (LifePolymer, LP) exhibits properties essential for heart valve leaflets, including low dynamic modulus, high tensile strength, minimal creep, and excellent biostability. LP's properties result from carefully designed “linked co‐macrodiol” chemistry that maximizes silicone content and virtual crosslinks between soft and hard phases. Characterization of multiple commercial batches demonstrates a robust synthesis process with minimal variation. Extensive ISO 10993–based biocompatibility testing results in no observable toxicity or other adverse reactions. An ex vivo AV shunt thrombogenicity investigation reveals nearly undetectable levels of platelet attachment and thrombus formation on LP surfaces. Chronic ovine implantation of prototype heart valves with LP leaflets shows no differences in thrombogenicity or systemic tissue response when compared to a clinically standard tissue‐based valve. Toxicological risk assessment, based on extractables and leachables analysis of LP‐based heart valves, confirms minimal toxicological risk. Lastly, 24‐week, strain‐accelerated in vivo LP biostability testing confirms previous favorable in vitro biostability findings. These studies demonstrate that this newly developed elastomer exhibits ideal biomaterial properties for the flexible leaflets of a totally synthetic heart valve replacement.
Investigation of basic imaging properties in digital radiography. 7. Noise Wiener spectra of II–TV digital imaging systems (1986)

We used Wiener spectral analysis in order to investigate the different noise sources and the effects of various parameters such as pixel size, image intensifier (II) field size, and exposure level on the noise in an II-TV digital system. The digital Wiener spectra in terms of relative x-ray intensity were determined directly from the digital noise data in terms of pixel values, by use of the characteristic curve of the imaging system. From averaged, subtracted, and/or combination images, the amount of structure mottle relative to the amount of quantum mottle was estimated. We found that a substantial amount of structure mottle was included in our II-TV digital subtraction angiography system, whereas the electronic noise of the TV system was quite small relative to the quantum and structure mottle. The effects of time jitter on the noise in single-frame images (consisting of multiple video frames) and in subtracted and averaged images were also investigated.
Interference coordination for millimeter wave communications in 5G networks for performance optimization (2019)

To address the increasing data rate demands for future wireless networks, a dense deployment of base stations or access points is the most promising approach; however, doing so may cause high intercell interference (ICI). Numerous interference coordination (IC) approaches have been proposed to reduce ICI. Conducting 5G communication on millimeter wave (mmWave) bands is more complex because of its higher propagation losses and greater attenuation variance, all of which depend on environment change. Massive antenna arrays with beamforming techniques can be used to overcome high propagation loss, reduce interference, deliver performance gains of coordination without a high overhead, and deliver high network capacity with multiplex transmitters. The central challenge of a massive antenna array that uses beamforming techniques is coordinating the users and beams for each transmitter within a large network. To address this challenge, we propose a novel two-level beamforming coordination approach that partitions a large network into clusters. At the intracluster level, this approach performs intracluster coordination similar to the user selection algorithms in a multiuser multiple input and multiple output (MU-MIMO); doing this maximizes the utility function or minimizes the signal-to-interference-plus-noise ratio (SINR) function within a cluster. A dynamic time domain IC approach is employed at the intercluster level, collecting interference information for cluster-edge user equipment (UE) and allocating the UE dynamically among the clusters to reduce the intercluster interference for a switched-beam system (SBS). Simulation results show that the proposed two-level IC approach achieves a higher edge user performance or cell capacity than with the current uncoordinated/coordinated approaches.
Genomic and allelic expression status of thep73 gene in human neuroblastoma (2001)

Therefore, in the p73 LOH NBs, the p73 gene could be altered in the maintained allele not by mutations [Ishimiya et al.: Med Pediatr Oncol, this issue], but rather by an abnormal transcription.
Influence of alkaline treatment on surface roughness and wetting properties of hydrophobized silk fabrics (2017)

The purpose of this research was to develop silk fabrics with dual-scale surface roughness, hydrophobicity, and self-cleaning properties. The surface roughness of 100% raw silk fabric was controlled by varying the temperature and time of degumming with NaOH solution to adjust the extent of sericin dissolution. Hydrophobization was carried achieved by depositing n-dodecyltrimethoxysilane on the silk fabric. The surface morphology, chemical composition, weight loss, tensile strength, luster, and color change of the fabric were measured, and the surface wettability was evaluated by water contact and shedding angle measurements. It was observed that the sericin on the fiber surface dissolved in the alkaline solution and formed nanoclusters. Consequently, because of the nanoscale roughness induced via the alkaline treatment, the contact angle increased from 0° to 152° after the hydrophobization, and the shedding angle decreased from 90° to 15°, indicating the superhydrophobicity of the resulting fabric. Therefore, alkaline treatment of silk fabric at 70℃ for 10 min was determined as the optimum condition for developing a self-cleaning silk fabric with an outstanding superhydrophobicity. The physical properties, such as tensile strength, luster, and color, were found to be the same even after the treatment.
Transparent SU-8 Three-Axis Micro Strain Gauge Force Sensing Pillar Arrays for Biological Applications (2007)

This paper presents three-axis micro strain gauge force-sensitive pillar arrays constructed of multiple layers of SU-8 and metal on quartz substrates to create transparent sensors for use in standard inverted microscopes. The sensor meets specific requirements for measuring tactile sensitivity and forces exerted during locomotion by small organisms such as fruit flies ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Drosophila</i> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">melanogaster</i> ), including: 1μN force sensitivity, >25μN range, and bio-compatibility By virtue of its three-axis capability, this sensor has flexible applications for biological and non-biological force sensing.
Abstract 3961: Sec23A is a regulative target of miR-200c and miR-375 in prostate cancer and influences cell growth in vitro (2011)

Abstract Background: Prostate cancer is a leading cause of tumor mortality. In order to identify the underlying mechanisms we have analyzed microRNA (miRNA) expression profiles of primary prostate cancers and non-cancer prostate tissue. Using database analysis, we sought to identify regulatory targets of aberrantly expressed miRNAs and to analyze the physiological consequences of miRNA deregulation using cell culture models. Material and Methods: We performed comparative miRNA expression profiling using deep sequencing of cDNA libraries and microarray analyses. Potential target genes of deregulated miRNAs were identified by database analysis and subsequently validated in vitro using reporter gene constructs. The impact of identified target genes on cell growth was examined by a standardized wound healing assay. Results: Two of the miRNAs consistently deregulated in primary prostate cancer samples were miR-200c and miR-375 which were upregulated more than 1.5-fold in deep sequencing and 2.9-fold and 3.9-fold, respectively, in microarray experiments (p&amp;lt;0.001, ANOVA). Independent target prediction databases (including miRanda, Targetscan and PicTar) indicated that the 3’ untranslated region (3’UTR) of the Sec23a gene is a regulative target for both miR-200c and miR-375. This prediction could be confirmed using a luciferase reporter gene construct containing the Sec23a 3’UTR. Co-expression of the reporter gene construct with either miR-200c or miR-375 resulted in a reduction of reporter gene activity while mutation of the miRNA binding sites caused a loss of responsiveness to the respective miRNA. Furthermore we could show that transient expression of miR-200c and miR-375 reduced the amount of Sec23a protein in the HEK293 cell line. A transient knock-down of Sec23a in DU145 prostate cancer cells applying siRNA technique led to acceleration of wound healing and transient overexpression of Sec23a to a deceleration over a time period of 30 hours. In Western blot analyses the majority of primary tissue samples displayed a reduced amount of Sec23a protein. Conclusion: Our findings demonstrate that the 3’-UTR of Sec23a is one regulative target of miR-200c and miR-375, which are commonly deregulated in prostate cancer. Sec23a is reduced in the majority of tumor samples analyzed and has a vital impact on cell growth as determined by wound healing experiments. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3961. doi:10.1158/1538-7445.AM2011-3961
Probing Xe Exchange in Delaminated Zeolites by Hyperpolarized 129Xe NMR (2007)

International audience
Towards attosecond XUV-pump XUV-probe measurements in the 100-eV region (2017)

Summary form only given. Nonlinear photoionization with energetic FEL pulses has opened up new horizons for the investigation of inner-shell electron dynamics in atomic and molecular systems [1]. So far, however, the limited temporal resolution (typically a few tens of femtoseconds) achievable with FELs has hampered the time resolution of these dynamics.Laser-driven XUV-sources are capable of producing isolated attosecond pulses and offer an alternative to FELs. However, the comparatively low pulse energies delivered by these sources has impeded their application to nonlinear optics. So far, only a few groups have demonstrated multi-photon ionization processes using laserdriven XUV-sources with photon energies below 50 eV [2-5]. Here, we use a novel laser-driven XUV-source to investigate and quantify nonlinear photoemission within the giant 4d resonance of xenon, at photon energies of 93 eV and 115 eV. Our XUV source [6], which is based on high-harmonic generation in the gas phase, is driven by a 10-Hz multi-TW laser system, the `Light-Wave Synthesizer 20' (LWS-20), that delivers sub-two-cycle 75 mJ pulses with a central wavelength around 740 nm [7], and from which we used 40 mJ on target. This high pulse energy allows for increasing the focus diameter to 365 micron full width at half maximum (FWHM), while maintaining a peak intensity on the order of 1015 W/cm2. The 35 m long beamline is designed to accommodate a loose focusing (f =17 m) into the generation chamber as well as a tight refocusing (XUV expansion length = 12.5 m) in the experimental chamber. The XUV pulse energy contained in the Zr transmission window (i.e. between 65 eV to the cutoff at 130 eV) amounts up to ~40 nJ. This is two orders of magnitude larger than what is typically achieved with kHz few-cycle driving pulses [8]. For the study of XUV-matter interactions, the XUV beam is focused into a xenon gas target, where different ionic charge states are generated via XUV photoionization. An ion microscope [9] is used to record the spatial distribution of the different charge states in the focus. The measured data allows for the characterization of the XUV focus and the determination of the two-photon ionization cross sections, which are compared to the predictions made with different theoretical models [10-12]. The present investigation of nonlinear photoemission in the 100-eV spectral region using a laser-driven XUV source represents a major step towards attosecond XUV-pump XUV-probe measurements in the 100-eV region and the study of time resolved non-linear inner-shell dynamics.
Unbound Free Fatty Acids from Preterm Infants Treated with Intralipid Decouples Unbound from Total Bilirubin Potentially Making Phototherapy Ineffective (2013)

Extremely low birth weight (ELBW; <1,000 g) infants have poor outcomes, often compromised by bilirubin neurotoxicity. We measured unbound bilirubin (Bf) and unbound free fatty acid (FFAu) levels in 5 ELBW infants in a trial examining the effects of pharmacologic ductal closure on infants treated with Intralipid infusion (3 g/kg/day). The levels for all infants (mean ± SD) were: total serum bilirubin (TSB) 4.6 ± 1.7 mg/dl, FFAu 376 ± 496 nM, and Bf 42 ± 30 nM. Of the 3 infants who died, 2 had TSB <5.9 mg/dl but FFAu >580 nM and Bf >75 nM. Multiple regression revealed a major effect on Bf levels due to FFAu, indicating that Intralipid elevated levels of FFAu and Bf. Indomethacin or ibuprofen reduced Bf levels, most likely by reducing FFAu levels through lipase inhibition. Because displacement of Bf by FFAu decouples Bf from TSB, phototherapy may not reduce the risk of bilirubin or FFAu toxicity in Intralipid-treated ELBW infants.
What is the Remodeling Potential of the Native Heart Valve? (2020)

Objective: Regenerative therapies directed at the restoration of heart valve function rely on an understanding on how native heart valve structures remodel and possibly regenerate. However, we know very little on how the native heart valve tissues remodel. This is especially true in conditions where the valve tissues themselves are non-pathological and remodeling occurs due to changes in external loading, i.e. in the dimensions of the external boundaries of the valve or transvalvular pressure. Methods: We demonstrate the remodeling potential of native heart valves showing how the mitral valve (MV) responds to volume overload (VO) and post-ischemic regurgitation (IMR). We studied the MV remodeling post-MI at the tissue, cellular, and transcriptomic levels. Results: We have found that MV tissue remodels in a two-phase fashion. In the first phase, there is permanent set-like deformation where no remodelling occurs, but changes in the mechanical behaviour of the MV leaflets reveal a significant decrease in radial direction extensibility. Parallel assessments of the MV interstitial cell (MVIC) nuclear aspect ratio, a metric of cellular deformation, revealed that MVICs were, on average, rounder. RNA sequencing (RNA-seq) indicated that YAP-induced genes were elevated, and genes related to extracellular matrix organization were downregulated. This phase was followed by a remodelling phase which resulted in near-complete restoration of homeostatic tissue-level behaviour. In addition, we observed that changes in the underlying MVIC geometry closely paralleled the tissue-level remodelling events. Conclusions: Collectively, these results suggest that valvular remodelling is actively mediated by the average VIC deformations (i.e. not cycle to cycle, but over a period of weeks). Moreover, tissue-level remodelling is likely accomplished by serial and parallel additions of fibrillar material to restore the mean homeostatic fibre stress and VIC geometries. This finding has significant implications in efforts to understand and predict valvular growth, remodelling, and potentially regeneration. KEYWORD: ICTEHV-O-01 The authors do not declare any conflict of interest.
Source Coding in Networks With Covariance Distortion Constraints (2016)

We consider a source coding problem with a network scenario in mind, and formulate it as a remote vector Gaussian Wyner-Ziv problem under covariance matrix distortions. We define a notion of minimum for two positive-definite matrices based on which we derive an explicit formula for the rate-distortion function. We then study the special cases and applications of this result. We show that two well-studied source coding problems, i.e., remote vector Gaussian Wyner-Ziv problems with mean-squared error and mutual information constraints are in fact special cases of our results. Finally, we apply our results to a joint source coding and denoising problem. We consider a network with a centralized topology and a given weighted sum-rate constraint, where the received signals at the center are to be fused to maximize the output SNR while enforcing no linear distortion. We show that one can design the distortion matrices at the nodes in order to maximize the output SNR at the fusion center. We thereby bridge between denoising and source coding within this setup.
Low Contact Resistance P-Type Electrode for Nonpolar m-Plane GaN (2013)

A low contact resistance p-type electrode for nonpolar m -plane GaN was obtained using Mg as the electrode material. Ga atoms diffused toward the Mg electrode after heat treatment. Because the Ga vacancies act as acceptors and form levels in the Schottky barrier, we consider hopping conduction through the Ga vacancy levels to be the main mechanism for the formation of the p-type ohmic contact to m -plane GaN. The specific contact resistance was reduced to 8×10 -4 Ω cm 2 by optimizing the heat treatment temperature and the Mg thickness. A significant reduction in the operating voltage of m -plane GaN LEDs was achieved by using this electrode technology.
Photoinduced intramolecular electron transfer mechanism for photochemical dissociation of para-substituted benzyl 9,10-dimethoxyanthracene-2-sulfonates (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoinduced intramolecular electron transfer mechanism for photochemical dissociation of para-substituted benzyl 9,10-dimethoxyanthracene-2-sulfonatesKazuhiko Naitoh, Koh Yoneyama, and Tsuguo YamaokaCite this: J. Phys. Chem. 1992, 96, 1, 238–244Publication Date (Print):January 1, 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/j100180a046https://doi.org/10.1021/j100180a046research-articleACS PublicationsRequest reuse permissionsArticle Views215Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts