gebhart/patrepeval huggingface dataset:
A case of metastatic pancreatic adenocarcinoma with prolonged survival after combination of neoadjuvant FOLFIRINOX therapy and synchronous distal pancreatectomy and hepatectomy (2014)

In this case report we detail the treatment of a patient with pancreatic ductal adenocarcinoma and a solitary liver metastasis who received nine cycles of FOLFIRINOX therapy with favourable response. The patient subsequently underwent synchronous distal pancreatectomy and hepatectomy with an R0 resection followed by three further cycles of FOLFIRINOX. At the last follow-up, 2 years from operation and 28 months from the diagnosis of metastatic pancreatic adenocarcinoma the patient remains disease free.
Autofocusing techniques for SAR imaging based on the multilag high order ambiguity function (1996)

INTRODUCTION Synthetic Aperture Radar (SAR) produces high resolution microwave images: the range resolution is c/2B, where c is the speed of light and B is the bandwidth of the transmitted signal (typically a chirp signal); the cross-range resolution is approximately A/2A0, where A is the transmission wavelength and A0 is the angle under which each point on the scene is observed from the radar [4]. The high cross-range resolution is obtained by coherently integrating the echoes received from each point of the observed scene during the observation interval. The coherent integration allows synthesis of an aperture much greater than the real aperture. A correct coherent integration however requires an accurate knowledge of the relative motion between the radar and the observed scene. On-board instrumentation provides the data relative to the position of the aircraft carrying the radar, but the accuracy with which these data are delivered by the instrumentation is much lower than that nec
Oral Care Reduces Pneumonia in Older Patients in Nursing Homes (2002)

We suggest that oral care may be useful in preventing pneumonia in older patients in nursing homes.
1pPA5 - What does multiple scattering tell us about rheology? (2021)

[Itinerary Planner](https://eventpilotadmin.com/web/planner.php?id=ASASPRING21) [Gather.town information](https://acousticalsociety.org/meeting-faq-gather-town-tour-yoga/) [Gather.town website (password: sound)](https://gather.town/app/lhwwaMoJFhRdAcyH/AcousticsInFocus2021) [Yoga Class, 9 June, 12:30 p.m.](https://us02web.zoom.us/meeting/register/tZwkf--srDIiH9VRaHkGAGXr3z29rov-MTBa) [Yoga Class, 10 June 12:30 p.m.](https://us02web.zoom.us/meeting/register/tZ0kf-usqTsqGNG3OYDNLOOpy64YUXjYCTR1)
The α Chemokine, Interleukin 8, Inhibits the Antiviral Action of Interferon α (1997)

Interferon (IFN) exhibits a potent antiviral activity in vitro and plays a major role in the early defense against viruses. Like IFN, the proinflammatory chemokine, interleukin (IL)-8, is induced by viruses and appears in circulation during viral infections. In an in vitro cytopathic effect assay for IFN, we found that IL-8 can inhibit IFN-alpha activity in a dose-dependent manner. This action was reversed by specific monoclonal antibodies to IL-8. The chemokine was able to attenuate the IFN-mediated inhibition of viral replication as determined by measuring infectious virus yield. IL-8 also diminished the ability of IFN to inhibit an early stage of viral replication since IL-8 attenuated the inhibition of the formation of viral proteins. It appeared that IL-8 interfered with a late rather than an early step of IFN-mediated pathway such as early gene expression. The IL-8 inhibitory action on IFN-alpha antiviral activity was associated with reduced 2',5'-A oligoadenylate synthetase activity, a pathway well correlative with the anti- encephalomyocarditis virus action of IFN-alpha. Understanding pathways that antagonize IFN action may lead to novel approaches to potentiate endogenous and therapeutic IFN.
Iterative method for the analysis of rectangular waveguides with external effective index correction (1998)

We discuss a simple, self-consistent iterative method for the analysis of rectangular waveguides with strong guidance. We show that this method removes the ambiguity of the conventional effective index method and gives a convergent value of the propagation constant both near and far from cutoff. Near the cut-off region, the accuracy can be improved by including an external effective index correction which takes into account the finite mode effect outside the waveguide.
Discovery of a new fragmentation reaction (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiscovery of a new fragmentation reactionPaul A. Wender and Charles J. ManlyCite this: J. Am. Chem. Soc. 1990, 112, 23, 8579–8581Publication Date (Print):November 1, 1990Publication History Published online1 May 2002Published inissue 1 November 1990https://pubs.acs.org/doi/10.1021/ja00179a051https://doi.org/10.1021/ja00179a051research-articleACS PublicationsRequest reuse permissionsArticle Views486Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Supplementary Figure Legends 1-7 from Mutations in the <i>DDR2</i> Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer (2023)

Supplementary Figure Legends 1-7 from Mutations in the &lt;i&gt;DDR2&lt;/i&gt; Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer
Data from β-Mannosylceramide Activates Type I Natural Killer T Cells to Induce Tumor Immunity without Inducing Long-Term Functional Anergy (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Most studies characterizing antitumor properties of invariant natural killer T (iNKT) cells have used the agonist, α-galactosylceramide (α-GalCer). However, α-GalCer induces strong, long-lasting anergy of iNKT cells, which could be a major detriment for clinical therapy. A novel iNKT cell agonist, β-mannosylceramide (β-ManCer), induces strong antitumor immunity through a mechanism distinct from that of α-GalCer. The objective of this study was to determine whether β-ManCer induces anergy of iNKT cells.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Induction of anergy was determined by &lt;i&gt;ex vivo&lt;/i&gt; analysis of splenocytes from mice pretreated with iNKT cell agonists as well as in the CT26 lung metastasis &lt;i&gt;in vivo&lt;/i&gt; tumor model.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; β-ManCer activated iNKT cells without inducing long-term anergy. The transience of anergy induction correlated with a shortened duration of PD-1 upregulation on iNKT cells activated with β-ManCer, compared with α-GalCer. Moreover, whereas mice pretreated with α-GalCer were unable to respond to a second glycolipid stimulation to induce tumor protection for up to 2 months, mice pretreated with β-ManCer were protected from tumors by a second stimulation equivalently to vehicle-treated mice.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; The lack of long-term functional anergy induced by β-ManCer, which allows for a second dose to still give therapeutic benefit, suggests the strong potential for this iNKT cell agonist to succeed in settings where α-GalCer has failed. &lt;i&gt;Clin Cancer Res; 19(16); 4404–11. ©2013 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
All-Focused Image Generation and 3D Modeling from Microscopic Images of Insects. (2002)

In this paper, we discribe a. method for generating an all-focused image from a. large number of microscopic images of insects. First, we describe our previously proposed select-and-merge method for all-focused image acquisition. We can obtain good results by using this method for two differently focused images. However, this method can't. give a good result when a large number of images are used. We thus developed a method that. compares each image with those preceding and following it based on the estimation of focused regions. We compare the results of image reconstruction by using the new method with those obtained by using our previously method. We then generate a 3D image bye using the intensity of an all-focused image and the depth of in-focus regions, both obtained by our proposed method.
ChemInform Abstract: Highly Stereoselective Synthesis of β‐Lactams by Condensation of the Titanium Enolate of a Chiral 2‐Pyridylthioester with Chiral Imines. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: REVERSING THE SELECTIVITY OF CYCLODEXTRIN BISIMIDAZOLE RIBONUCLEASE MIMICS BY CHANGING THE CATALYST GEOMETRY (1980)

Abstract Die unkatalysierte Hydrolyse des Phosphats (III) ergibt die Spaltprodukte (II) und (IV) im Verhältnis 1:1.
Bounded influence magnetotelluric response function estimation (2004)

Author Posting. © Blackwell, 2004. This article is posted here by permission of Blackwell for personal use, not for redistribution. The definitive version was published in Geophysical Journal International 157 (2004): 988–1006, doi:10.1111/j.1365-246X.2004.02203.x.
Modulating spin transfer torque switching dynamics with two orthogonal spin-polarizers by varying the cell aspect ratio (2014)

We study in-plane magnetic tunnel junctions with additional perpendicular polarizer for subnanosecond-current-induced switching memories. The spin-transfer-torque switching dynamics was studied as a function of the cell aspect ratio both experimentally and by numerical simulations using the macrospin model. We show that the anisotropy field plays a significant role in the dynamics, along with the relative amplitude of the two spin-torque contributions. This was confirmed by micromagnetic simulations. Real-time measurements of the reversal were performed with samples of low and high aspect ratio. For low aspect ratios, a precessional motion of the magnetization was observed and the effect of temperature on the precession coherence was studied. For high aspect ratios, we observed magnetization reversals in less than 1 ns for high enough current densities, the final state being controlled by the current direction in the magnetic tunnel junction cell.
Iterative linear MMSE transmit and receive strategies for cellular MIMO networks (2009)

We present two iterative algorithms that jointly optimize the transmit and receive filters with respect to the mean square error (MSE) in the downlink of a cellular multi-user multiple input single output (MISO) system for linear precoding. One algorithm is gradient-based and allows for cooperation among base stations, the second algorithm does not allow for cooperation between base stations and regards the base stations as competing players in a game. Furthermore, we propose a ¿smart¿ initialization which outperforms all other approaches we analyze without any need for iteration.
An Anatomical Heart Model with Applications to Myocardial Activation and Ventricular Mechanics (2020)

A three-dimensional finite element model of the mechanical and electrical behavior of the heart is being developed in a collaboration among Auckland University, New Zealand; the University of California at San Diego, U.S.; and McGill University, Canada. The equations of continuum mechanics from the theory of finite deformation elasticity are formulated in a prolate spheroidal coordinate system and solved using a combination of Galerkin and collocation techniques. The finite element basis functions used for the dependent and independent variables range from linear Lagrange to cubic Hermite, depending on the degree of spatial variation and continuity required for each variable. Orthotropic constitutive equations derived from biaxial testing of myocardial sheets are defined with respect to the microstructural axes of the tissue at the Gaussian quadrature points of the model. In particular, we define the muscle fiber orientation and the newly identified myocardial sheet axis orientation throughout the myocardium using finite element fields with nodal parameters fitted by least-squares to comprehensive measurements of these variables. Electrical activation of the model is achieved by solving the FitzHugh-Nagumo equations with collocation at fixed material points of the anatomical finite element model. Electrical propagation relies on an orthotropic conductivity tensor defined with respect to the local material axes. The mechanical constitutive laws for the Galerkin continuum mechanics model are (1) an orthotropic "pole-zero" law for the passive mechanical properties of myocardium and (2) a Wiener cascade model of the active mechanical properties of the muscle fibers. This chapter concentrates on two aspects of the model: first, grid generation, including both the generation of nodal coordinates for the finite element mesh and the generation of orthotropic material axes at each computational point, and, second, the formulation of constitutive laws suitable for numerically intensive finite element computations. Extensions to this model and applications to the mechanical and electrical function of the heart are described in Chapter 16 by McCulloch and co-workers.
BRIDJE over a language barrier (2003)

This paper describes two new features of the BRIDJE system for cross-language information access. The first feature is the partial disambiguation function of the Bi-directional Retriever, which can be used for search request translation in cross-language IR. Its advantage over a "black-box" machine translation approach is consistent across five test collections and across two language permutations: English-Japanese and Japanese-English. The second new feature is the Information Distiller, which performs interactive summarisation of retrieved documents based on Semantic Role Analysis. Our examples illustrate the usefulness of this feature, and our evaluation results show that the precision of Semantic Role Analysis is very high.
Nano state Machines using hysteretic resistors and diode crossbars (2006)

A nanoelectronic architecture is proposed that combines configurable, nanoscale diode crossbars with hysteretic resistor crossbars in order to implement general sequential circuits ("nano state machines"). The resulting circuits are inherently nonvolatile, require no static power dissipation, and are tolerant of variation in device characteristics. They are also unusual in that state information is stored using impedance encoding rather than voltage encoding. An example state machine, a two-bit counter, is modeled in SPICE and analyzed.
On the fly synthesis of edit suggestions (2019)

When working with a document, users often perform context-specific repetitive edits – changes to the document that are similar but specific to the contexts at their locations. Programming by demonstration/examples (PBD/PBE) systems automate these tasks by learning programs to perform the repetitive edits from demonstration or examples. However, PBD/PBE systems are not widely adopted, mainly because they require modal UIs – users must enter a special mode to give the demonstration/examples. This paper presents Blue-Pencil, a modeless system for synthesizing edit suggestions on the fly. Blue-Pencil observes users as they make changes to the document, silently identifies repetitive changes, and automatically suggests transformations that can apply at other locations. Blue-Pencil is parameterized – it allows the ”plug-and-play” of different PBE engines to support different document types and different kinds of transformations. We demonstrate this parameterization by instantiating Blue-Pencil to several domains – C# and SQL code, markdown documents, and spreadsheets – using various existing PBE engines. Our evaluation on 37 code editing sessions shows that Blue-Pencil synthesized edit suggestions with a precision of 0.89 and a recall of 1.0, and took 199 ms to return suggestions on average. Finally, we report on several improvements based on feedback gleaned from a field study with professional programmers to investigate the use of Blue-Pencil during long code editing sessions. Blue-Pencil has been integrated with Visual Studio IntelliCode to power the IntelliCode refactorings feature.
SMART (strategic memory allocation for real-time) cache design (2003)

A discussion is presented as to why the present approach to cache architecture design results in unpredictable performance improvements in real-time systems with priority-based preemptive scheduling algorithms. The SMART cache design is shown to be compatible with the goals of scheduling in a real-time system. The results of this research provide a scheme not only for utilizing the performance enhancement provided by hierarchical memory designs, but also for fine tuning these enhancements to provide increased benefit to the desired scheduling goal.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
ChemInform Abstract: Intermolecular [8 + 2] Cycloaddition Reactions of 2H‐3‐Methoxycarbonylcyclohepta[b]furan‐2‐one with Vinyl Ethers: An Approach to Bicyclo[5.3.0]azulene Derivatives. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
High-Density Optical Backplane Using Small Diameter Optical Fiber (2006)

Rapidly increasing broadband access has led to the requirement for much higher transmission throughput within a network equipment. The most promising solution is optical interconnection using an optical backplane. We have developed a high-density optical backplane using a small-diameter optical fiber to realize multi-tera bit/s throughput. To achieve this, we developed a new high-delta and small-diameter optical fiber (clad diameter=80μm, coating diameter=125μm), a high-den-sity optical fiberboard with small bending radius (r=5mm), a high-density MT ferrule, an easy assemble MT ferrule and compact optical right angle connector. Using these new devices, we fabricated a high-density optical backplane, which complies with the structure of an ATCA backplane. It has achieved a high throughput performance of 3 Tbit/s, which is five times that of an electric backplane.
Corrections to “Asymmetrical Spectral Response in Fiber Fabry–Pérot Interferometers” (2010)

In the above titled paper (ibid., vol. 27, no. 24, pp. 5648-5656, Dec. 09), there was an error with some embedded fonts.
Deep Reinforcement Learning with Modulated Hebbian plus Q Network Architecture (2019)

This paper presents a new neural architecture that combines a modulated Hebbian network (MOHN) with DQN, which we call modulated Hebbian plus Q network architecture (MOHQA). The hypothesis is that such a combination allows MOHQA to solve difficult partially observable Markov decision process (POMDP) problems which impair temporal difference (TD)-based RL algorithms such as DQN, as the TD error cannot be easily derived from observations. The key idea is to use a Hebbian network with bio-inspired neural traces in order to bridge temporal delays between actions and rewards when confounding observations and sparse rewards result in inaccurate TD errors. In MOHQA, DQN learns low level features and control, while the MOHN contributes to the high-level decisions by associating rewards with past states and actions. Thus the proposed architecture combines two modules with significantly different learning algorithms, a Hebbian associative network and a classical DQN pipeline, exploiting the advantages of both. Simulations on a set of POMDPs and on the MALMO environment show that the proposed algorithm improved DQN's results and even outperformed control tests with A2C, QRDQN+LSTM and REINFORCE algorithms on some POMDPs with confounding stimuli and sparse rewards.
In situ destruction of contaminants via hydrous pyrolysis/oxidation. Visalia Field Test (1998)

A field test of hydrous pyrolysis/oxidation (HPO) was conducted during the summer of 1997, during a commercial application of thermal remediation (Dynamic Underground Stripping (DUS)) at the Visalia Pole Yard (a super-fund site) in southern California. At Visalia, Southern California Edison Co. is applying the DUS thermal remediation method to clean up a large (4.3 acre) site contaminated with pole-treating compounds. This is a full-scale cleanup, during which initial extraction of contaminants is augmented by combined steam/air injection in order to enhance the destruction of residual contaminants by HPO. Laboratory results indicate that the contaminants at Visaha react at similar rates to TCE, which has been the focus of extensive laboratory work (Knauss et al., 1998a-c). Field experimental results from this application yield valuable information (1) confirming the destruction of contaminants in soil and groundwater by HPO, (2) validating the predictive models used to design HP0 steam injection systems, (3) demonstrating that accurate field measurements of the critical fluid parameters can be obtained using existing monitoring wells and (4) obtaining a reasonable prediction of the cost and effectiveness of HPO, working at a commercial scale and with commercial partners. The goal of our additional study and demonstration in conjunction with Edison has been to obtain early proof of hydrous pyrolysis/oxidation in the field, and validate our predictive models and monitoring strategies. This demonstration provides valuable economic and practicability data obtained on a commercial scale, with more detailed field validation than is commonly available on a commercially-conducted cleanup. The results of LLNL' s field experiments constrain the destruction rates throughout the site, and enable site management to make accurate estimates of total in situ destruction based on the recovered carbon. As of October, 1998, over 900,000 lb of contaminant have been removed from the site; about 18% of this has been destroyed in situ.
Widely tunable high-speed bulk-micromachined short-wavelength MEMS-VCSEL (2010)

We present the first results of a high-speed bulk-micromachined tunable vertical-cavity surface-emitting laser (VCSEL) operating near 850nm using a half-symmetric resonator with a movable curved microelectromechanical system (MEMS) membrane.