gebhart/patrepeval huggingface dataset:
Genetic Deletion and Pharmacological Inhibition of Nogo-66 Receptor Impairs Cognitive Outcome after Traumatic Brain Injury in Mice (2010)

Functional recovery is markedly restricted following traumatic brain injury (TBI), partly due to myelin-associated inhibitors including Nogo-A, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMgp), that all bind to the Nogo-66 receptor-1 (NgR1). In previous studies, pharmacological neutralization of both Nogo-A and MAG improved outcome following TBI in the rat, and neutralization of NgR1 improved outcome following spinal cord injury and stroke in rodent models. However, the behavioral and histological effects of NgR1 inhibition have not previously been evaluated in TBI. We hypothesized that NgR1 negatively influences behavioral recovery following TBI, and evaluated NgR1(-/-) mice (NgR1(-/-) study) and, in a separate study, soluble NgR1 infused intracerebroventricularly immediately post-injury to neutralize NgR1 (sNgR1 study) following TBI in mice using a controlled cortical impact (CCI) injury model. In both studies, motor function, TBI-induced loss of tissue, and hippocampal beta-amyloid immunohistochemistry were not altered up to 5 weeks post-injury. Surprisingly, cognitive function (as evaluated with the Morris water maze at 4 weeks post-injury) was significantly impaired both in NgR1(-/-) mice and in mice treated with soluble NgR1. In the sNgR1 study, we evaluated hippocampal mossy fiber sprouting using the Timm stain and found it to be increased at 5 weeks following TBI. Neutralization of NgR1 significantly increased mossy fiber sprouting in sham-injured animals, but not in brain-injured animals. Our data suggest a complex role for myelin-associated inhibitors in the behavioral recovery process following TBI, and urge caution when inhibiting NgR1 in the early post-injury period.
The Results of Exchange Reamed Intramedullary Nails For Severe Tibial Shaft Fractures Initially Treated By Nonreamed Nails (1993)

Templeman, David C.; Thomas, Mark; Varecka, Thomas F.; Kyle, Richard F. Author Information
Ethylene polymerization and copolymerization with a polar monomer using an α‐iminocarboxamide nickel complex activated by trimethylaluminum (2007)

Abstract An α‐iminocarboxamide nickel complex was activated by trimethylaluminum (TMA) and used in the polymerization of ethylene and its copolymerization with 10‐undecen‐1‐ol. The best activity was observed upon activation with 9 equiv of TMA at a temperature of 26 °C. NMR spectroscopic studies did not show 10‐undecen‐1‐ol incorporation. However, FTIR analyses suggest the incorporation of a very small amount of comonomer, which affects the glass transition temperature, the degree of branching, and the mechanical properties of the materials. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 54–59, 2008
Dynamics of the collinear beryllium + hydrofluoric acid .fwdarw. beryllium fluoride + hydrogen reaction (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDynamics of the collinear beryllium + hydrofluoric acid .fwdarw. beryllium fluoride + hydrogen reactionHeloiza. Schor, Sally. Chapman, Sheldon. Green, and Richard N. ZareCite this: J. Phys. Chem. 1979, 83, 8, 920–922Publication Date (Print):April 19, 1979Publication History Published online1 May 2002Published inissue 19 April 1979https://pubs.acs.org/doi/10.1021/j100471a007https://doi.org/10.1021/j100471a007research-articleACS PublicationsRequest reuse permissionsArticle Views33Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Fluorometric Assay for Measurement of Viral Neuraminidase--Application to the Rapid Detection of Influenza Virus in Nasal Wash Specimens (1980)

A sensitive assay was developed for the measurement of neuraminidase with use of the 4-methylumbelliferkyl-alph-ketoside of N-acetyl-neuraminic acid as a fluorescent substrate. Neuraminidase activity was detected in preparation containing small quantities of cultivated influenza virus as well as in some nasal wash specimens from human volunteers experimentally infected with influenza A/Alaska/78 virus. Activity due to influenza viral neuraminidase could be distinguished from activity due to bacterial or mammalian (fibroblast) neuraminidase by means of enzyme inhibition with ethylenediaminetetraacetate, a chelating agent. The same substrate could be used in a solid-phase assay to determine the antigenic type of the influenza viral neuraminidase. The fluorescent neuraminidase assay takes 2-4 hr to perform and uses equipment available in many laboratories. Thus, it offers promise for the rapid detection of influenza viruses in cell cultures and clinical specimens.
Application of Electron Paramagnetic Resonance Spectroscopy to Surfactants on Surfaces (1996)

The application of various EPR experiments to the study of surfactants adsorbed on surfaces from aqueous media is described. Published work using TEMPO and doxyl stearic acid spin-probes is critically reviewed, and new work utilizing spin-labeled cetyltrimethylammonium bromide is discussed to illustrate the use of 100% spin-labeled material to study surfactant aggregation, and the use of paramagnetic broadeners to study surfactant aggregate structure.
Mask cost and cycle time reduction (2003)

In the IC industry the mask cost and cycle time have increased dramatically since the chip design has become more complex and the required mask specification, tighter. The lithography technology has been driven to 65-nm node and 90-nm product will be manufacturing in 2004, according to ITRS's roadmap. However, the optical exposure tools do not extend to a shorter wavelength as the critical dimension (CD) shrinks. In such sub-wavelength technology generation, the mask error factor (MEF) is normally higher. Higher MEF means that tighter mask specification is required to sustain the lithography performance. The tighter mask specification will impact both mask processing complexity and cost. The mask is no longer a low-cost process. In addition, the number of wafers printed from each mask set is trending down, resulting in a huge investment to tape out a new circuit. Higher cost discourages circuit shrinking, thus, prohibits commercialization of new technology nodes.
Toward D-peptide biosynthesis: Elongation Factor P enables ribosomal incorporation of consecutive D-amino acids (2017)

To maintain stereospecific biochemistry in cells, living organisms have evolved mechanisms to exclude D-amino acids ( D AA) in their protein synthesis machinery, which also limits our exploration of the realm of mirror-image molecules. Here, we show that high affinity between EF-Tu and aminoacyl-tRNA promotes D-amino acid incorporation. More strikingly, Elongation Factor P efficiently resolves peptidyl transferase stalling between two consecutive D-amino acids, and hence enables the translation of D-peptides.
Utilizing Miniature Fluorescence Microscopy to Image Hippocampal Place Cell Ensemble Function in Thy1.GCaMP6f Transgenic Mice (2018)

Imaging neuronal activity in awake behaving mice with miniature fluorescence microscopes requires the implementation of a variety of procedures. Surgeries are performed to gain access to the cell population of interest and to implant microscope components. After a recovery period, mice are trained to exhibit a desired behavior. Finally, neuronal activity is imaged and synchronized with that behavior. To take full advantage of the technology, selection of the calcium indicator and experimental design must be carefully considered. In this article, we explain the procedures and considerations that are critical for obtaining high-quality calcium imaging data. As an example, we describe how to utilize miniature fluorescence microscopy to image hippocampal place cell activity during linear track running in Thy1.GCaMP6f transgenic mice. © 2018 by John Wiley & Sons, Inc.
Adhesion characteristics of Listeria adhesion protein (LAP)-expressing Escherichia coli to Caco-2 cells and of recombinant LAP to eukaryotic receptor Hsp60 as examined in a surface plasmon resonance sensor (2006)

Listeria adhesion protein (LAP) is an important adhesion factor in Listeria monocytogenes and interacts with its cognate receptor, mammalian heat shock protein 60 (Hsp60). The genetic identity of LAP was determined to be alcohol acetaldehyde dehydrogenase (Aad). A recombinant Escherichia coli strain expressing aad confirmed the involvement of Aad in adhesion to Caco-2 cells. Binding kinetics (ka) of recombinant LAP (rLAP) to Hsp60 was examined in a surface plasmon resonance sensor and was determined to be 5.35 x 10(8) M(-1) s(-1) and it was equivalent to the binding of anti-Hsp60 antibody (ka = 2.15 x 10(9) M(-1) s(-1)) to Hsp60. In contrast, Internalin B, an adhesion/invasion protein from L. monocytogenes, used as a control, had binding kinetics (ka) of only 2.9 x 10(6) M(-1) s(-1). The KD value of rLAP was 1.68 x 10(-8) M, which was significantly lower than Internalin B (KD = 6.5 x 10(-4) M). These results suggest that Hsp60 has significantly higher avidity for anti-Hsp60 antibody and LAP than Internalin B. In summary, LAP is identified as an alcohol acetaldehyde dehydrogenase and binding of recombinant E. coli to Caco-2 cells or rLAP to Hsp60 protein was found to be highly specific.
A streaming FPGA implementation of a steerable filter for real-time applications (abstract only) (2011)

Oriented filters are used in many early vision and image processing tasks for feature extraction at arbitrary orientations. Steerable filters are a class of filters in which a filter of arbitrary orientation is synthesized as a linear combination of a set of basis filters. In this work, we describe a streaming implementation of a steerable filter on FPGAs, which includes a two-dimensional convolution filter and a modulator for modulation by a set of oriented sine waves. We present a highly configurable streaming 2D convolution implementation and a novel separable look-up-table based implementation of the modulation step. This steerable filter has been extended to multiple resolutions to realize a steerable pyramid filter. Experimental results on a Virtex6 FPGA show that the steerable pyramid filter provides up to 14X and 21X speedups over related FPGA and CPU implementations respectively. This work was supported in part by a grant from NSF 0916887 and DARPA Neovision2 programs.
Surpassing soliton compression limits in anomalous dispersion high-power erbium fiber comb (2021)

Femtosecond power scaling in anomalous dispersion waveguides like telecom fiber is limited by runaway pulse collapse. We achieve an order of magnitude increase over previous femtosecond erbium fiber lasers by using phase-only pulse shaping in a stretcher fiber Bragg grating and identify a truncated Jacobi elliptic function pulse shape with better nonlinear compression characteristics than standard pulses. We generate 1560 nm, 340 nJ, 63 fs, 2.4 MW peak power pulses at 25 MHz repetition rate with standard single-mode fiber and a chirped mirror pair rather than bulk gratings. At a higher 100 MHz repetition rate, we verify frequency comb stability with 110 nJ, 62 fs pulses at 11 W average power. This record output can combine comb precision with strong field physics, and the method broadly applies to improving ultrafast laser sources.
Method of Minimal Evidence: Model‐Based Reasoning (2012)

This chapter contains sections titled: Overview Introduction Method of Minimal Evidence Overview Verifying the Validity and Accuracy of the Various Primary Models Summary References
Evaluating the performance and privacy of a token-based collaborative recommender (2017)

The rapid expansion of available online services has raised concerns about user privacy. In the online world, only a minority of users is actually aware where their data is stored and the policies, how the data may be eventually used. However, at the same time consumers expect more quality from online services, demanding personalized services that fit their individual needs, preferences and values. One approach for service personalization is to use collaborative recommenders. From the privacy perspective, mainstream collaborative recommenders present an inherent security risk, since they are based on memorizing user-item transactions. In this paper, we will study a recently developed token-based method (sometimes referred as an acronym "upcv") which creates privacy-protecting abstraction that is based on collections of randomly generated tokens. These collections are capable of providing information for collaborative recommendations without maintaining any transactional history. This paper presents quality evaluation of item-to-item recommendations using the token-based collaborative recommender, utilizing ISBN agencies of Book-Crossing dataset (BX) books at the data set. This paper will also discuss challenges related to BX. Privacy issues are evaluated with a specific emphasis on the concept of deniability.
RIS-assisted Cell-Free MIMO with Dynamic Arrivals and Departures of Users: A Novel Network Stability Approach (2023)

Reconfigurable Intelligent Surfaces (RIS) have recently emerged as a hot research topic, being widely advocated as a candidate technology for next generation wireless communications. These surfaces passively alter the behavior of propagation environments enhancing the performance of wireless communication systems. In this paper, we study the use of RIS in cell-free multiple-input multiple-output (MIMO) setting where distributed service antennas, called Access Points (APs), simultaneously serve the users in the network. While most existing works focus on the physical layer improvements RIS carry, less attention has been paid to the impact of dynamic arrivals and departures of the users. In such a case, ensuring the stability of the network is the main goal. For that, we propose an optimization framework of the phase shifts, for which we derived a low-complexity solution. We then provide a theoretical analysis of the network stability and show that our framework stabilizes the network whenever it is possible. We also prove that a low complexity solution of our framework stabilizes a guaranteed fraction (higher than 78.5%) of the stability region. We provide also numerical results that corroborate the theoretical claims.
Abstract 1305: Identification of signal transduction kinases inhibited by pan-RAF inhibitor belvarafenib using FRET imaging technique (2019)

Abstract The mitogen-activated protein kinase (MAPK) pathway plays an important role for the survival and proliferation of tumor cells. For example, the activation of the MAPK pathway due to mutations in BRAF, NRAS and KRAS kinases is known to be the causes of various solid tumors and hematologic malignancies. Accordingly, there is a strong need for effective therapeutic drugs for treating cancers caused by genetic mutation of BRAF, NRAS or KRAS. Belvarafenib (HM95573 or GDC5573), currently in Phase 1 clinical trials, is a selective and orally bioavailable pan-RAF kinase inhibitor. When biochemically assayed for hundreds of kinases, Belvarafenib showed selectivity toward RAF family kinases, including strong inhibition activities for BRAF WT, BRAF mutants and CRAF. Previously, we reported that Belvarafenib strongly inhibits the growth of cancer cell lines with BRAF, NRAS or KRAS mutations and also shows excellent anticancer efficacy in animal models using the corresponding cancer cells. In this study, employing fluorescence resonance energy transfer (FRET) imaging, we examined which protein kinases involved in signal transduction are regulated by Belvarafenib and investigated the mechanism of action for the regulation in typical cancer cells harboring BRAF, NRAS or KRAS mutations such as A375 (melamona), SK-MEL-30 (Kwmelamona), HCT116 (CRC), and Calu-6 (NSCLC). Among the various protein kinases that can be involved in signal transduction, we identified with time-lapse FRET imaging that the phosphorylation of ERK, AKT and S6K are inhibited after the treatment of Belvarafenib in the above cancer cells of BRAF, NRAS or KRAS mutations. Of note, BRAF mutant selective inhibitors, Vemurafenib and Dabrafenib were not active in cancer cells of NRAS or KRAS mutations. These results correlate with the in vitro and in vivo anticancer activity in cancer cells of BRAF, NRAS or KRAS mutations. In conclusion, unlike Vemurafenib and Dabrafenib, the pan-RAF inhibitor Belvarafenib could be effective for treating the cancer caused by NRAS or KRAS mutations, as well as BRAF mutations. Citation Format: Dong-Jun Bae, Sang-Yeob Kim, JooYun Byun, InHwan Bae, YoungGil Ahn, YoungHoon Kim, Kwee Hyun Suh. Identification of signal transduction kinases inhibited by pan-RAF inhibitor belvarafenib using FRET imaging technique [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1305.
The Membrane Proteome of Sensory Cilia to the Depth of Olfactory Receptors (2014)

In the nasal cavity, the nonmotile cilium of olfactory sensory neurons (OSNs) constitutes the chemosensory interface between the ambient environment and the brain. The unique sensory organelle facilitates odor detection for which it includes all necessary components of initial and downstream olfactory signal transduction. In addition to its function in olfaction, a more universal role in modulating different signaling pathways is implicated, for example, in neurogenesis, apoptosis, and neural regeneration. To further extend our knowledge about this multifunctional signaling organelle, it is of high importance to establish a most detailed proteome map of the ciliary membrane compartment down to the level of transmembrane receptors. We detached cilia from mouse olfactory epithelia via Ca(2+)/K(+) shock followed by the enrichment of ciliary membrane proteins at alkaline pH, and we identified a total of 4,403 proteins by gel-based and gel-free methods in conjunction with high resolution LC/MS. This study is the first to report the detection of 62 native olfactory receptor proteins and to provide evidence for their heterogeneous expression at the protein level. Quantitative data evaluation revealed four ciliary membrane-associated candidate proteins (the annexins ANXA1, ANXA2, ANXA5, and S100A5) with a suggested function in the regulation of olfactory signal transduction, and their presence in ciliary structures was confirmed by immunohistochemistry. Moreover, we corroborated the ciliary localization of the potassium-dependent Na(+)/Ca(2+) exchanger (NCKX) 4 and the plasma membrane Ca(2+)-ATPase 1 (PMCA1) involved in olfactory signal termination, and we detected for the first time NCKX2 in olfactory cilia. Through comparison with transcriptome data specific for mature, ciliated OSNs, we finally delineated the membrane ciliome of OSNs. The membrane proteome of olfactory cilia established here is the most complete today, thus allowing us to pave new avenues for the study of diverse molecular functions and signaling pathways in and out of olfactory cilia and thus to advance our understanding of the biology of sensory organelles in general.
Measurement of Horse Allergens Equ c 1 and Equ c 2: A Comparison among Breeds (2022)

Our results show high intra- and inter-breed variability. Neither the American Curly horse nor the Russian Bashkir horse, earlier categorized as hypoallergenic breeds, was associated with lower allergen levels of Equ c 1, Equ c 2, or Equ c 4 than the other horse breeds investigated.
An Algorithm for Automatically Calculating Component Current Ratings in Switched-Capacitor DC-DC Converters (2018)

Switched capacitor (SC) dc–dc converters, which have traditionally been used for on-chip power supplies, are now being considered for medium to high-power applications. This paper presents a method for automatically synthesizing SC converters as well as deriving the expressions for their charge-multipliers. Charge multipliers can be used to calculate important design characteristics such as converter output voltage regulation, efficiency, and component current ratings, which can then be used to appraise different topologies. However, whilst a full appraisal of converters also requires component voltage ratings, this work is the first step in developing an automatic software tool that will employ a search-based algorithm to generate optimum SC topologies for a given application. The method is based on the proposition that all SC converters can be synthesized from a so-called “basic cell”. The automatic derivation and solution of the charge transfer equations for a traditional Fibonacci SC converter is presented as an example of the proposed method, which is validated against existing analytic equations as well as a detailed Spice simulation. The automatic calculation of the charge-multipliers for two other well-known SC converters is also demonstrated, including a new, arbitrarily generated circuit, which again is validated against detailed spice simulations.
Heparin decreases the rate of proliferation of rat vascular smooth muscle cells by releasing transforming growth factor -like activity from serum (1993)

Heparins of varying molecular weight and anticoagulant properties all partially inhibited VSMC proliferation predominantly by extending the G2/M phase of the cell cycle. Heparin also inhibited dedifferentiation of primary cultures of VSMCs. Heparin (< 100 micrograms.ml-1) acted extracellularly to release TGF beta from serum, which accounted for the effects of heparin on proliferation and differentiation.
Is Decompensation Preoperatively a Risk in Lenke 1C Curves? (2013)

3.
An architecture for self-organization in pervasive systems (2010)

Pervasive computing environments consist of many independent collaborating electronic devices, including sensors and actuators. Ad-Hoc extendibility of such systems is desirable but the current network technologies use the concept of a central coordinator device in the network or define application profiles which are not easy to extend and maintain. The distributed architecture proposed in this paper allows these devices to organize themselves automatically to execute some pervasive system application without the intervention of a central controlling device. The knowledge that defines interactions between these devices is derived from an ontological model of a particular domain. This knowledge is distributed over the devices such that every device only has information about its own interactions and operations. A simple demonstration of this architecture is presented.