gebhart/patrepeval huggingface dataset:
Immunophenotypic and functional characterization of human tonsillar mast cells (1997)

Mast cells (MC) are proinflammatory immune cells residing in various organs. Tissue-specific heterogeneity of MC has been described. The aim of this study was to establish the phenotype and functional profile of human tonsillar mast cells (ToMC) and to compare ToMC with lung-, skin-, and uterus MC. Tonsillar tissue was obtained from 23 patients suffering from hyperplastic tonsils and dispersed by enzymatic digestion. With the use of a combined toluidine blue/immunofluorescence staining technique, isolated ToMC were found to react with monoclonal antibodies (mAb) to immunoglobulin E, CD9, CD43, CD44, CD46, CD54, CD55, and CD59, as well as mAb to stem cell factor (SCF) receptor (CD117/c-kit). ToMC were not recognized by mAb to other cytokine receptors or mAb to CD3, CD11b, CD14, CDw17, the skin MC marker CD88 (C5aR) or CD89 (Fc alphaR). Activation of ToMC by recombinant human (rh) SCF or anti-IgE resulted in histamine secretion, whereas no effects were seen with rhC5a, rh granulocyte-macrophage colony-stimulating factor, or rh interleukin-1 through -10. In summary, ToMC exhibit functional and phenotypic properties similar to lung- or uterus MC. Unlike skin MC, ToMC lack C5aR and are unresponsive to rhC5a.
Optimization of Metal Quality for Grating Coupled Surface Plasmon Resonance (2013)

Silver coated gratings were fabricated using an ultraviolet nanoimprint process followed by an electron beam evaporation method. A SiO2 mold was used for the nanoimprint. The long and short range surface plasmon modes could be observed by adjusting the refractive indices of top and bottom surface layers of silver grating. The surface roughness (Ra) of silver affected the surface plasmon resonance characteristics. The deep and narrow plasmon coupling dip could be observed for the silver film with Ra less than 2 nm.
pH Dependence of the Rate and Quantum Yield of the Retinal Photoisomerization in Bacteriorhodopsin (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTpH Dependence of the Rate and Quantum Yield of the Retinal Photoisomerization in BacteriorhodopsinStephan L. Logunov, Li Song, and Mostafa A. El-SayedCite this: J. Phys. Chem. 1994, 98, 42, 10674–10677Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/j100093a003https://doi.org/10.1021/j100093a003research-articleACS PublicationsRequest reuse permissionsArticle Views181Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Resistance to invasive pneumococcal infection in mice with acute allergic lung inflammation (P3228) (2013)

Abstract Streptococcus pneumoniae is the most common cause of bacterial pneumonia which results in 175,000 hospitalizations as well as 40,000 deaths in the United States annually. Recent work has identified a link between asthma and invasive pneumococcal disease (IPD) prompting the Advisory Committee on Immunization Practices to recommend that all adults with asthma receive vaccination. To study the underlying mechanism responsible for an increased risk of IPD for individuals with asthma, we used an acute model of ovalbumin (OVA)-induced allergic lung inflammation (ALI) and hypothesized that mice with acute ALI would be more susceptible than naive mice to a pulmonary S. pneumoniae infection. Surprisingly, mice with acute ALI were more resistant to infection than naïve controls and this increased resistance was found to be greatest 10 days following the final OVA challenge. While inflammatory cell infiltration and cytokine levels in the bronchoalveolar lavage (BAL) fluid had returned to levels similar to naïve controls by day 10, this time point also correlated with the peak of IgA expression in the BAL fluid, suggesting a critical role for non-specific IgA in protection against IPD. Indeed, protection against IPD was lost in IgA KO mice with ALI as well as naïve IgA KO mice.
Carbocyanine dye-patterned microbubbles as ultrasound-modulated fluorescent contrast agents (2021)

Combining fluorescence and acoustic techniques enables the characterization of biochemical environments with optical sensors while utilizing the penetration depth and spatial resolution of focused ultrasound. Localized light generation within a small tissue volume can yield spatially resolved chemical information useful for delineating tissue pathology such as cancerous lesions. Our work develops fluorescent microbubble contrast agents that generate light in the focal zone of an ultrasound beam through modulation of their fluorescence intensity. Microbubbles were designed with a self-quenching lipophilic dye patterned within the lipid layer, enabling the dye molecules to quench and dequench with the ultrasound-driven particle size oscillations. Distinct dye patterns were generated on the microbubble surfaces and investigated for their ultrasound-driven fluorescence response. By amplifying the microbubble fluorescence intensity modulations using a lock-in amplifier, the optical signal from these locally activated particles was detected within an optically scattering environment and at significant depth. We additionally observed that these microbubbles also displayed harmonic oscillations of fluorescence intensity beyond the ultrasound driving frequency which could be used to further improve the signal-to-noise ratio for detection. This technique could enable sensitive optical imaging with ultrasound-scale millimeter-level spatial resolution, providing a valuable tool to address the challenge of optical imaging in deep tissue.
Above 20% External Quantum Efficiency in Thermally Activated Delayed Fluorescence Device Using Furodipyridine-Type Host Materials (2014)

High efficiency green thermally activated delayed fluorescence device with a quantum efficiency above 20% was developed using a bipolar host material, 3-(furo[2,3-b:5,4-b′]dipyridin-3-yl)-N,N-diphenylaniline (3TPAPFP), derived from furodipyridine core structure. The furodipyridine based 3TPAPFP showed a singlet and triplet energy for efficient energy transfer to thermally activated delayed fluorescent dopant, (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile (4CzIPN), and bipolar charge transport properties for balanced hole and electron density. A high quantum efficiency of 21.2% was achieved in the fluorescent device using the 3TPAPFP host doped with 4CzIPN dopant at a very low doping concentration of 1%.
Quantitative investigation of material erosion caused by high-pressure discharges in air and nitrogen (2004)

Abstract Single-spark erosion experiments were conducted in different pure metal samples. The samples were used as the cathode, and a platinum electrode was used as the anode. The sparks were produced at high pressure and room temperature, having at this conditions a breakdown phase (ca. 100 ns) and an arc phase (several hundreds of ls). The crater volumes on the different materials were correlated with several properties of materials, in view of different models of material erosion related to melting enthalpy, vaporization enthalpy and sublimation energy. It was found that the quotient between the eroded volume and the spark energy correlates well with a function of the energy necessary to heat the material up to the melting point and to melt it. The particle ejection model can be used to explain this process. Moreover, it was found that the crater shape is related to the surface tension of the molten material. These investigations may be relevant for the development of high-performance materials for ele...
Seyferth-Gilbert Homologation as a Novel Route to F-18-labeled Building Blocks: Preparation of Radiofluorinated Phenylacetylenes and their Application in PET Chemistry (2016)

1101 Objectives Radiofluorinated arylacetylenes represent potentially very useful building blocks which could provide access to numerous novel radiolabeled compounds of high interest. Their radiosynthesis has not been reported yet, albeit a rapid development of radiofluorination methods has taken place in recent years. Herein we describe the efficient preparation of hitherto unknown [18F]fluorophenylacetylenes (n-[18F]FPAs) via Seyferth-Gilbert Homologation.
							
							 Methods n-[18F]FPAs were synthesized from the corresponding [18F]fluorobenzaldehydes ([18F]FBAs) using the Bestmann-Ohira reagent. The application of 2- and 4- [18F]FPAs as building blocks to produce various radiolabeled compounds was studied. These were prepared via (3+2) cycloaddition reactions, the radio-Kinugasa reaction, the copper-free Sonogashira coupling and the Rh-catalyzed (2+2+2) cycloaddition. Furthermore, the building blocks were used to produce PET tracers. Thereby, 18F-labeled variants of an amino acid [18F]1, a COX-2 ( [18F]2) and a PSMA ( [18F]3) specific ligand were prepared. Results n-[18F]FPAs were obtained under optimized reaction conditions (120 °C, 15 min) in RCYs of 40-60%. The reactions of n-[18F]FPAs with various substrates provided 18F-labeled model compounds in 18-54% RCC. The two potential PET tracers and the radiolabeled amino acid were obtained in RCCs of 75-84%.
							
							 Conclusions The first application of the Seyferth-Gilbert homologation in PET chemistry is reported. This approach enables the fast and simple access to radiofluorinated phenylacetylenes. A wide application scope of the novel synthons was demonstrated by the preparation of various radiolabeled model compounds and PET tracers via (3+2) cycloadditions and cross-coupling reactions.
An Adaptable and Dynamically Porous Organic Salt Traps Unique Tetrahalide Dianions (2013)

Bis(I2)-Addukte von Hexamethoniumdihalogeniden sind so organisiert, dass sie auf dynamisches Heizen reagieren und eine Struktur annehmen können, aus der die Bildung von relativ instabilen, bisher unbekannten [I2Br2]2−- und [I2Cl2]2−-Tetrahalogeniden möglich ist, die in Lösung nicht erhalten werden können (siehe Bild). Die kavitätsgesteuerte Reaktivität bietet neue Möglichkeiten für die Synthese und Umwandlung von Polyhalogenanionen.
New ring‐rearranged metabolite of 20‐hydroxyecdysone obtained by base‐catalyzed auto‐oxidation (2015)

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A Pioneer’s Flash of Insight (2008)

In the May/June issue of Queue, Eric Allman wrote a tribute to Jim Gray, mentioning that Queue would be running some of Jim’s best works in the months to come. I’m embarrassed to confess that when this idea was first discussed, I assumed these papers would consist largely of Jim’s seminal work on databases showing only that I (unlike everyone else on the Queue editorial board) never knew Jim. In an attempt to learn more about both his work and Jim himself, I attended the tribute held for him at UC Berkeley in May.
An Innovative Wireless H2S Sensor Based on Nanotechnology to Improve Safety in Oil & Gas Facilities (2013)

Abstract Real-time monitoring of pollutant, toxic and flammable gases is important for health and safety of petroleum extraction and distribution operations. Small, lightweight, fast, low-power, low-cost sensors would enable ubiquitous monitoring of these gases, which would allow for prevention of exposure or explosions and aid in rapid response to hazardous leaks. Currently, there are many methods of detecting such gases, but most sensors suffer either from slow response times, high power consumption, high cost and/or inability to operate in harsh conditions. Here we demonstrate a small, low-cost, low-power, highly sensitive and selective nanomaterials-based gas sensor, specifically targeted for the detection of hydrogen sulfide (H2S). A network of WO3 nanoparticles is heated by an on-chip microhotplate while the conductance of the network is monitored. The device can be heated with short pulses (&amp;lt;100 ms) without diminishing the sensor response, thereby drastically lowering the power consumption to less than 1 mW. The sensor shows high sensitivity to H2S, but it does not have direct cross sensitivities to H2O or CH4, two gases likely to be seen in industrial operation. This low power H2S sensor has been integrated into a low cost, stand-alone monitoring system capable of measuring multiple environmental conditions, including temperature, humidity, and H2S concentration, and distributing that information via wireless protocols, namely 802.15.4 and 802.11 (WiFi). These environmental detection systems can communicate directly to smart phones via WiFi or be configured into a wireless mesh network of detection systems capable of relaying real-time environmental conditions and location to a safety monitor at a remote location. The nanoparticle-based sensor and integrated detection system developed here, once packaged as a fully manufactured tool, can enable a low-cost solution to real-time monitoring of environmental conditions that will greatly reduce the likelihood of hazardous conditions becoming disasters.
A cost effective, energy saving boosted evaporation process for alumina refineries (2018)

Evaporation process is a significant section in the alumina production by the Bayer Process. It consumes a large amount of thermal energy and helps to manage water balance. We introduce a novel flash boosted evaporation process that can reduce live steam consumption for evaporation purposes, by using the available waste flash vapour from the last stage of the evaporation unit. The process can economise on the consumption of live steam, as waste flash vapour injection into the patent pending Flash Boosted Thermal-Vapour Compression Multi-Effect Evaporation (FB-TVC-MEE) process is able to minimise the motive steam usage of the Thermal-Vapour Compressor (TVC). We compare this novel FB-TVC-MEE process with the conventional Thermal-Vapour Compression Multi-Effect Evaporation (TVC-MEE) process and the current Multi-Stage Flash (MSF) process in terms of the amount of saved live steam, Gain Output Ratio (GOR), and specific pumping power consumption. <br/>Our result shows that 82% of the current live steam consumption can be saved, with our process having the ability to exploit all the available flashed vapour for the evaporation of feed spent liquor. The Gain Output Ratio of our design is 468% better than the current MSF system and 98% better than the conventional TVC-MEE process. With regards to the pumping power consumption, the FB-TVC-MEE process shows a 5% increase as compared to the TVC-MEE process. Importantly, at a risk discount rate of 10%, the FB-TVC-MEE process has been shown to cost the least (both capex and opex considered), auguring 57% net present cost savings compared to the standard MSF technology that consumes 40 ton per hour of live steam with a baseline capex of $30 mil.
Data from First-in-Human Study of the Radioligand <sup>68</sup>Ga-N188 Targeting Nectin-4 for PET/CT Imaging of Advanced Urothelial Carcinoma (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Nectin-4 is an emerging biomarker for cancer diagnosis and therapy. Recently, enfortumab vedotin (EV) was approved by the FDA as the first nectin-4 targeting antibody–drug conjugate for treating advanced urothelial carcinoma (UC). A PET imaging method to noninvasively quantify nectin-4 expression level would potentially help to select patients most likely to respond to EV and predict the response.&lt;/p&gt;Experimental Design:&lt;p&gt;In this study, we designed a bicyclic peptide-based nectin-4 targeting radiotracer &lt;sup&gt;68&lt;/sup&gt;Ga-N188. Initially, we performed preclinical evaluations of &lt;sup&gt;68&lt;/sup&gt;Ga-N188 in UC cell lines and xenograft mouse models. Next, we performed the translational study in healthy volunteers and a pilot cohort of patients with advanced UC on uEXPLORER total-body PET/CT.&lt;/p&gt;Results:&lt;p&gt;In the preclinical study, &lt;sup&gt;68&lt;/sup&gt;Ga-N188 showed high affinity to nectin-4, specific uptake in a nectin-4(+) xenograft mouse model, and suitable pharmacokinetic and safety profiles. In the translational study, 2 healthy volunteers and 14 patients with advanced UC were enrolled. The pharmacokinetic profile was determined for &lt;sup&gt;68&lt;/sup&gt;Ga-N188, and the nectin-4 relative expression level in different organs was quantitatively imaged.&lt;/p&gt;Conclusions:&lt;p&gt;A clear correlation between PET SUV value and nectin-4 expression was observed, supporting the application of &lt;sup&gt;68&lt;/sup&gt;Ga-N188 PET as a companion diagnostic tool for optimizing treatments that target nectin-4.&lt;/p&gt;&lt;p&gt;&lt;i&gt;&lt;a href="https://aacrjournals.org/clincancerres/article/doi/10.1158/1078-0432.CCR-23-1243" target="_blank"&gt;See related commentary by Jiang et al., p. 3259&lt;/a&gt;&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
A Novel Algorithm to Estimate the Pulse Pressure Variation Index&lt;tex&gt;$Deltarm PP$&lt;/tex&gt; (2004)

We designed a new methodology to estimate the pulse pressure variation index (deltaPP) in arterial blood pressure (ABP). The method uses automatic detection algorithms, kernel smoothing, and rank-order filters to continuously estimate deltaPP. The technique can be used to estimate deltaPP from ABP alone, eliminating the need for simultaneously acquiring airway pressure.
Measurements of attenuation coefficient for evaluating the hardness of a cataract lens by a high-frequency ultrasonic needle transducer (2009)

A cataract is a clouding of the lens in the eye that affects vision. Phacoemulsification is the mostly common surgical method for treating cataracts, and determining that the optimal phacoemulsification energy is dependent on measuring the hardness of the lens. This study explored the use of an ultrasound needle transducer for invasive measurements of ultrasound attenuation coefficient to evaluate the hardness of the cataract lens. A 47 MHz high-frequency needle transducer with a diameter of 0.9 mm was fabricated by a polarized PMN-33%PT single crystal in the present study. The attenuation coefficients at different stages of an artificial porcine cataract lens were measured using the spectral shift approach. The hardness of the cataract lens was also evaluated by mechanical measurement of its elastic properties. The results demonstrated that the ultrasonic attenuation coefficient was increased from 0.048 +/- 0.02 to 0.520 +/- 0.06 dB mm(-1) MHz(-1) corresponding to an increase in Young's modulus from 6 +/- 0.4 to 96 +/- 6.2 kPa as the cataract further developed. In order to evaluate the feasibility of combining needle transducer and phacoemulsification probe for real-time measurement during cataract surgery, the needle transducer was mounted on the phacoemulsification probe for a vibration test. The results indicated that there was no apparent damage to the tip of the needle transducer and the pulse-echo test showed that a good performance in sensitivity was maintained after the vibration test.
Supplementary Table S4 from A Clinical PET Imaging Tracer ([<sup>18</sup>F]DASA-23) to Monitor Pyruvate Kinase M2–Induced Glycolytic Reprogramming in Glioblastoma (2023)

&lt;p&gt;Vital signs of the patients administered with [18F]DASA-23&lt;/p&gt;
Stereochemistry of the nickel(II) complexes of the macrocycle meso-2,12-dimethyl-3,7,11,17-tetraazabicyclo-[11.3.1]heptadeca-1(17),13,15-triene (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereochemistry of the nickel(II) complexes of the macrocycle meso-2,12-dimethyl-3,7,11,17-tetraazabicyclo-[11.3.1]heptadeca-1(17),13,15-trieneEiichiro Ochiai and Daryle H. BuschCite this: Inorg. Chem. 1969, 8, 8, 1798–1799Publication Date (Print):August 1, 1969Publication History Published online1 May 2002Published inissue 1 August 1969https://pubs.acs.org/doi/10.1021/ic50078a055https://doi.org/10.1021/ic50078a055research-articleACS PublicationsRequest reuse permissionsArticle Views42Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Tags, micro-tags and tag editing: improving internet search (2009)

Social tagging is an emerging methodology that allows individual users to assign semantic keywords to content on the web. Popular web services allow the community of users to search for content based on these user-defined tags. Tags are typically attached to a whole entity such as a web page (e.g., del.icio.us), a video (e.g., YouTube), a product description (e.g., Amazon) or a photograph (e.g., Flickr). However, finding specific information within a whole entity can be a difficult, time-intensive process. This is especially true for content such as video, where the information sought may be a small segment within a very long presentation. Moreover, the tags provided by a community of users may be incorrect, conflicting, or incomplete when used as search terms. In this paper we introduce a system that allows users to create "micro-tags," that is, semantic markers that are attached to subsets of information. These micro-tags give the user the ability to direct attention to specific subsets within a larger and more complex entity, and the set of micro-tags provides a more nuanced description of the full content. Also, when these micro-tags are used as search terms, there is no need to do a serial search of the content, since micro-tags draw attention to the semantic content of interest. This system also provides a mechanism that allows users in the community to edit and delete each others' tags, using the community to refine and improve tag quality. We will also report on empirical studies that demonstrate the value of micro-tagging and tag editing and explore the role micro-tags and tag editing will play in future applications.
ChemInform Abstract: Organosilicon Chemistry. Part 125. Silicon‐Directed Cyclization of Vinylsilanes Bearing Hydroxy Group Catalyzed by an Acid. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.