gebhart/patrepeval huggingface dataset:
DNA Damage Due to Diradical‐Generating Cyclizations (2009)

This chapter contains sections titled: Introduction Diradical-Generating Cyclizations of Enediyne Natural Products DNA Cleavage Chemistry of Enediyne Natural Products DNA Adducts and Cross-Links with Enediyne Natural Products Designed DNA Cleavage Agents Based on Other Diradical-Generating Cyclizations Conclusions Acknowledgments References
VP2P: A Virtual Machine-Based P2P Testbed for VoD Delivery (2009)

Recent advances in P2P technology have made it a viable alternative for the delivery of rich media by both content and service providers. However, to better understand and utilize P2P technologies in building a scalable media distribution platform, the nature of the underlying network must be taken into consideration. Although many P2P simulations have been conducted previously, very few were evaluated on a real P2P testbed with the properties of the physical network in mind. In this paper, we describe VP2P, a virtual machine-based P2P testbed, which supports P2P studies with the consideration of typical service provider networks. We use four fully equipped MacPro's to emulate 32 peers in the current implementation. Experiments of three P2P algorithms for video on demand (VoD) services: BitTorrent, Toast, and Zebra, were run on the testbed. We discuss the rationales behind the hardware and software architecture of VP2P, report our results, and conclude with lessons learned and future directions for VM-based testbeds.
Biological Thinning of Fruit Set by RNAase in Deciduous Fruit Trees (1993)

Fruit thinning is a common and necessary practice for commercial fruit production in many deciduous tree fruit species. Fruit thinning in apple may be accomplished with a variety of chemical thinning agents, but the use of these chemicals is a subject of environmental concern. It has been shown recently that RNase enzyme, secreted from the stigma and the style, inhibits pollen germination and pollen tube elongation. In this study we have been able to show that Aspergillus niger B-1 RNase can effectively inhibit peach and apple pollen germination, and tube elongation in-vitro, as well as thin fruit in peach and apple, and reduce the number of seeds in citrus. The objectives of the research were to detrmine the conditions for effective thinning of (USA and Israel), develop fermentation process for cost effective production of RNase from A. niger. (Israel), and clone apple S-RNase cDNA (USA). All the objectives of the research were addressed. We have determined the optimal fermentation conditions for cost effective production of the A. niger at a 20,000 liters scale. TheA. niger B1 RNase was isolated to homogeneity and its kinetic and biochemical properties including its N-terminal sequence were fully characterized. The field test results both in Israel and California have shown variability in effectiveness and more work is needed to define the RNase concentration necessary to completely inhibit pollen development. Plant transformation vectors expressing anti-sense apple S-RNase genes were constructed (USA) with an attempt to produce self compatible transgenic apple trees. Bovine S-Protein cDNA was cloned and successfully expressed in E. coli (Israel). Plant transformation vector expressing the S-Protein gene was constructed (USA) with an attempt to produce transgenic plants expressing S-protein in the style. Exogenous application of S-peptide to these plants will result in active RNase and consequently prevention of fertilization.
Surface‐enhanced Raman spectroscopic study of amsacrine and amsacrine–DNA interactions (1992)

Abstract Surface‐enhanced Raman scattering (SERS) spectroscopy has been employed to study the interaction of intercalating ligands with DNA. SERS was used to obtain spectra of acridine, aminoacridine, the 9‐anilinoacridine amsacrine and related compounds at associated solution concentrations down to 1 μM. A major advantage of SERS was the near absence of fluorescence normally inherent in solution spectra of these compounds. SERS spectra of amsacrine–DNA complexes at various ligand/base pair ratios showed free ligand concentrations consistent with those calculated from the binding constant, and showed that the less strongly interacting acridine was largely unbound even at high ligand/base pair ratios.
Optical Spectroscopy and Crystal Field Studies of the Mn4+ Ion (3d3) in the Double Perovskite NaLaMgTeO6 (2014)

The spectroscopic properties of the Mn 4+ ion (3d 3 ) in the double perovskite NaLaMgTeO 6 are reported in this work. Evidence is presented for the occupation by the Mn 4+ ion of both the six coordinated Mg 2+ and Te 6+ sites in the host structure. The Mn 4+ energy levels are calculated using the exchange charge model of crystal field theory for both occupied sites. The results of our calculations yield the crystal field splitting and Racah parameters of Dq = 2008 cm −1 , B = 790 cm −1 , C =2881 cm −1 , with C/B=3:65 (Mg 2+ site) and Dq=2008 cm −1 , B=790 cm −1 ,C =2949 cm −1 , with C/B = 3:73 (Te 6+ site). A cross-cutting comparative study of the variations in the crystal field splitting and the Racah parameters of the six-coordinated Mn 4+ ion in a series of materials with the perovskite structure are presented.
Scale down of p-n junction diodes of an uncooled IR-FPA for improvement of the sensitivity and thermal time response by 0.13-Âµm CMOS technology (2011)

We have developed an uncooled infrared radiation focal plane array (IR-FPA) with 22 &mu;m pitch and 320 × 240 pixels utilizing silicon p-n junction diodes, which were fabricated by 0.13 &mu;m CMOS technology and bulk-micromachining. The thermal time response of cells was lowered to be 16msec by reduction of thermal capacity of cells. In addition to increase the sensitivity of cells by extending the length of supporting beams, p-n junction diode was scaled down as small as 20% in area compared to previous one. Micro-holes were formed in the cell to reduce only thermal capacity, which were negligibly small compared to incident IR wavelength. This method needs no additional process step and is considered as suitable for low cost and mass-productive IR-FPA.
Digital optical elements and technologies (EDO19): applications to AR/VR/MR (2019)

This paper serves as an introduction to the EDO19 conference “Digital Optical Technologies” dedicated specifically to digital optics for AR/VR and MR Head Mounted Display (HMD) systems, in all their incarnations: Display, Imaging and Sensors. We will introduce the field of AR/VR/MR optics historically, and review the most important criteria for AR/VR/MR optical design: matching the performances of the optics to the ones of the human visual system. This can be done for all Digital Optical Elements reviewed throughout this conference: free space optics, waveguide optics (waveguide combiners), diffractive, holographic and metasurface optical elements, tunable, switchable and reconfigurable optics, and novel computational techniques for display and imaging.
Ventajas restaurativas de implantes con cabeza hexagonal externa (1993)

El cirujano y el dentista que va a llevar a cabo la restauracion protesica deben trabajar en equipo y seleccionar conjuntamente el sistema de implantes que quieren utilizar,de forma que les aporte el mejor resultado protesico.
Increased potency of killed vee (TC-83) vaccine in mice previously infected with EEE virus (1975)

Journal Article Increased potency of killed vee (TC-83) vaccine in mice previously infected with EEE virus Get access Albert T. McManus, Albert T. McManus Virology Division U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21701, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Gerald A. Eddy Gerald A. Eddy Virology Division U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21701, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 69, Issue 1, 1975, Page 172, https://doi.org/10.1016/0035-9203(75)90040-1 Published: 01 January 1975
Supplementary Table 1 from Combined MEK and PI3K Inhibition in a Mouse Model of Pancreatic Cancer (2023)

&lt;p&gt;Supplementary Table 1. Excel spreadsheet showing results of drug screen indicating relative sensitivity of PDAC cell lines compared to non-PDA cell lines.&lt;/p&gt;
ChemInform Abstract: Cross‐Metathesis Reaction. Generation of Highly Functionalized Olefins from Unsaturated Alcohols. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Imaging reagents study for nuclear medicine using an electron-tracking Compton gamma-ray camera (2009)

We have developed an electron-tracking Compton camera (ETCC) for new imaging reagents study. Energy limitation of gamma camera is major problem for this study. However, our ETCC has a wide energy dynamic range (200-1300 keV). In this paper, we show the results of imaging reagent study as follows: (1) F-18-FDG (511 keV) and I-131-MIBG (364 keV) simultaneous imaging for double clinical tracer imaging, (2) Zn-65-porphyrin (1116 keV) imaging for high energy gamma-ray imaging and, (3) middle size animal imaging (rabbit). Also we studied the improvement for the camera system.
Tutorial on Acoustic Fluid Loading of Structures (2021)

Any vibrating structure is loaded by the fluid surrounding it. Whether air, water, or something else, the fluid loading adds a spatially distributed resistance (in phase with the vibration) and reactance (out of phase with the vibration) over the structural surfaces. The resistance absorbs energy, and damps structural vibrations. The reactance is either mass-like, effectively adding to the structural density, reducing resonance frequencies and vibration amplitudes; or stiffness-like, increasing resonance frequencies. Usually, mass-like reactance is caused by fluids external to a structure, and stiffness-like reactance is caused by enclosed volumes of fluids. This tutorial uses analytic methods to compare and contrast external and internal fluid loading on a flat rectangular plate and demonstrates the effects of fluid loading on plate vibration and radiated sound. The well-known stiffening effect of the internal Helmholtz resonance is demonstrated for a thin panel and a shallow entrained cavity. The differences between heavy (water) and light (air) external fluid loading are also demonstrated, with significant reductions in resonance frequencies and peak vibration amplitudes for water loading.
Energy-Efficient Smart Packet Access in WCDMA Networks: Performance with TCP/IP based Applications (2005)

This paper presents a performance analysis of adaptive packet access (PA) in WCDMA networks with TCP/IP based applications. The focus is on optimal tradeoffs between energy efficiency and TCP throughput over burst-error correlated fading channels. The channel model is adopted for low mobility PA applications. Both high-speed PA (HSPA) and low-speed PA (LSPA) with radio-link retransmission-and-error-control protocols are studied. By theoretical analysis and simulation, we show that in HSPA adapting the radio-packet retransmission period to the channel conditions significantly reduces the number of retransmissions while maintaining adequate TCP performance. This method is referred to as smart packet dispatching (SPD). In LSPA, adapting the length of radio packets to the channel conditions significantly increases the effective TCP throughput. This method is referred to as smart packet length (SPL). The SPD and SPL, commonly called smart packet access (SPA), are capable of avoiding burst-error states of correlated fading channels and therefore enhance the robustness of radio transmissions and allow the system to operate with much lower fade margin or transmit-power. Furthermore, the SPA schemes improve energy efficiency and system performance without need of excessive signal processing.
Characterization of the Interferon Regulatory Factor-7 and Its Potential Role in the Transcription Activation of Interferon A Genes (1998)

The family of interferon regulatory factors (IRFs) plays an important role in modulating cellular responses to viral infection and cytokines, including IFNs. The transcription factors that are involved in the transcriptional activation of the IFNB gene have been extensively studied. However, the molecular mechanism by which virus activates the expression of the IFNA gene remains to be defined. Recently, we have identified a new IRF-7 isoform, denoted as IRF-7H, which encodes a protein of 514 amino acids and is most closely related to the IRF-3. The expression of IRF-7 is restricted to the lymphoid cell types and is inducible by virus, lipopolysaccharide, and IFNA. The functional characterization of IRF-7H reveals a presence of transactivation domain located carboxyl-terminal to its DNA binding domain. Overexpression of IRF-7H results in an activation of IFNA promoter in transient transfection assay and a strong enhancement of virus-mediated activation of this promoter. Whereas in uninfected cells, overexpressed IRF-7H is present mainly in the cytoplasm, viral infection facilitates the transfer of IRF-7H to the nucleus; overexpression of IRF-3 interferes with the virus-induced translocation of IRF-7H. Thus, IRF-7 exhibits functional similarity to IRF-3; however, the preferential expression of IRF-7 in lymphoid cells (the cell type that expresses IFNA) suggests that IRF-7 may play a critical role in regulating the IFNA gene expression.
A conditional replication-competent adenoviral vector, Ad-OC-E1a, to cotarget prostate cancer and bone stroma in an experimental model of androgen-independent prostate cancer bone metastasis. (2001)

Prostate cancer has a high propensity to metastasize to bone, which often resists hormone, radiation, and chemotherapies. Because of the reciprocal nature of the prostate cancer and bone stroma interaction, we designed a cotargeting strategy using a conditional replication-competent adenovirus to target the growth of tumor cells and their associated osteoblasts. The recombinant Ad-OC-E1a was constructed using a noncollagenous bone matrix protein osteocalcin (OC) promoter to drive the viral early E1a gene with restricted replication in cells that express OC transcriptional activity. Unlike Ad-PSE-E1a, Ad-OC-E1a was highly efficient in inhibiting the growth of PSA-producing (LNCaP, C4-2, and ARCaP) and nonproducing (PC-3 and DU145) human prostate cancer cell lines. This virus was also found to effectively inhibit the growth of human osteoblasts and human prostate stromal cells in vitro. Athymic mice bearing s.c. androgen receptor-negative and PSA-negative PC-3 xenografts responded to a single intratumoral administration of 2 x 10(9) plaque-forming unit(s) of Ad-OC-E1a. In SCID/bg mice, intraosseous growth of androgen receptor-positive and PSA-producing C4-2 xenografts responded markedly to i.v. administrations of a single dose of Ad-OC-E1a. One hundred percent of the treated mice responded to this systemic Ad-OC-E1a therapy with a decline of serum PSA to an undetectable level, and 80% of the mice with PSA rebound responded to the second dose of systemic Ad-OC-E1a. Forty percent of the mice were found to be cured by systemic Ad-OC-E1a without subsequent PSA rebound or tumor cells found in the skeleton. This cotargeting strategy shows a broader spectrum and appears to be more effective than systemic Ad-PSE-E1a in preclinical models of human prostate cancer skeletal metastasis.
Precise indoor localization systems: Alternative methods for sub-sampling UWB pulses and associated error sources (2013)

A millimeter precision indoor ultra-wideband (UWB) localization system has been developed for high accuracy indoor localization applications including surgical navigation. We use two competing sub-sampling techniques in our system: the first technique exploits a small frequency shift of the transmitter clock and the receiver clock; the second technique uses a delay line chip at the receiver side. We discuss the limitations of these sub-sampling systems in the context of achieving sub-mm precision performance for biomedical applications requiring high accuracy indoor localization.
Incremental dense semantic stereo fusion for large-scale semantic scene reconstruction (2015)

Our abilities in scene understanding, which allow us to perceive the 3D structure of our surroundings and intuitively recognise the objects we see, are things that we largely take for granted, but for robots, the task of understanding large scenes quickly remains extremely challenging. Recently, scene understanding approaches based on 3D reconstruction and semantic segmentation have become popular, but existing methods either do not scale, fail outdoors, provide only sparse reconstructions or are rather slow. In this paper, we build on a recent hash-based technique for large-scale fusion and an efficient mean-field inference algorithm for densely-connected CRFs to present what to our knowledge is the first system that can perform dense, large-scale, outdoor semantic reconstruction of a scene in (near) real time. We also present a `semantic fusion' approach that allows us to handle dynamic objects more effectively than previous approaches. We demonstrate the effectiveness of our approach on the KITTI dataset, and provide qualitative and quantitative results showing high-quality dense reconstruction and labelling of a number of scenes.
Measurement of Bs0 meson production in pp and PbPb collisions at sNN=5.02 TeV (2019)

The production cross sections of B 0 s mesons and charge conjugates are measured in proton-proton (pp) and PbPb collisions via the exclusive decay channel B 0 s J/ + -K + K -at a center-of-mass energy of 5.02 TeV per nucleon pair and within the rapidity range |y| < 2.4 using the CMS detector at the LHC. The pp measurement is performed as a function of transverse momentum (p T ) of the B 0 s mesons in the range of 7 to 50 GeV/c and is compared to the predictions of perturbative QCD calculations. The B 0 s production yield in PbPb collisions is measured in two p T intervals, 7 to 15 and 15 to 50 GeV/c, and compared to the yield in pp collisions in the same kinematic region. The nuclear modification factor (R AA ) is found to be 1.5 0.6(stat) 0.5(syst) for 7-15 GeV/c, and 0.87 0.30(stat) 0.17(syst) for 15-50 GeV/c, respectively. Within current uncertainties, the B 0 s results are consistent with models of strangeness enhancement, and suppression by parton energy loss, as observed for the B + mesons.
Unlocking Autonomous Mobility (2019)

Autonomous cars are expected to dramatically redefine the future of transportation. When fully realized, this technology promises to unlock a myriad societal, environmental, and economic benefits. From a technical standpoint, autonomous cars pose significant challenges. An autonomous car needs to perceive the world around it, it needs to maintain a precise geographic context of its location, it needs to predict the future state of all dynamic agents, and finally, it needs to plan its own trajectory to progress to its destination.
Frequency of visualization of presumed celiac ganglia by endoscopic ultrasound (2007)

Celiac ganglia can be visualized by EUS in most patients who undergo upper gastrointestinal EUS examinations, and are best seen with linear-array echo endoscopes. Ganglia can usually be differentiated from lymph nodes on the basis of their endosonographic appearance.
SUMMARY OF RECENT RESEARCH ON GROWTH RATE DISPERSION OF CONTACT NUCLEI (1986)

Recent contact nucleation studies are reviewed. The importance of the phenomenon of growth rate dispersion determining the crystal size distribution is discussed. Directions for future work are suggested.
Transcriptome Analysis Reveals Organ-Specific Effects of 2-Deoxyglucose Treatment in Healthy Mice (2023)

These findings suggest that 2DG has a systemic impact that varies across organs, potentially affecting multiple pathways and functions. The study provides insights into the potential therapeutic benefits of 2DG across different diseases and highlights the importance of understanding its systemic effects for future research and clinical applications.
Application-aware Networking (APN) Framework (2020)

A multitude of applications are carried over the network, which have
varying needs for network bandwidth, latency, jitter, and packet loss,
etc. Some new emerging applications (e.g. 5G) have very demanding
performance requirements. However, in current networks, the network
and applications are decoupled, that is, the network is not aware of
the applications' requirements in a fine granularity. Therefore, it
is difficult to provide truly fine-granularity traffic operations for
the applications and guarantee their SLA requirements. This document
proposes a new framework, named Application-aware Networking (APN),
where application characteristic information such as application
identification and its network performance requirements is carried in
the packet encapsulation in order to facilitate service provisioning,
perform application-level traffic steering and network resource
adjustment.
Cell and Molecular Biological Challenges of ICSI: ART before Science? (1998)

Authors discuss the possible genetic and cell biological risks to offspring conceived by ICSI in relation to the lack of fundamental research using relevant animal models.
Moderate increases in plasma cholesterol blunt the inflammatory response to salt‐induced hypertension (2011)

Although an increased leukocyte and platelet adhesion is observed in cerebral venules of mice with either hypertension (HTN) or hypercholesterolemia (HCh), it remains unclear whether the combination of HTN and HCh exerts a comparable effect on leukocyte and platelet recruitment in the cerebral microvasculature. We examined whether HCh alters platelet and leukocyte adhesion in cerebral venules of hypertensive mice. A 50 mg DOCA pellet was implanted s.c. in uninephrectomized C57Bl/6 mice placed on 1 % saline for a period of 3 weeks. A 3‐week HCh diet did not alter blood pressure either alone or in combination with HTN. Donor platelets labeled with CSFE were administered i.v., along with rhodamine, for in vivo observation of platelets and leukocytes using intravital microscopy. The HTN‐induced recruitment of adherent leukocytes in cerebral venules was blunted by the presence of HCh. Platelet adhesion was unaffected by either HTN, HCh or a combination thereof. The role of HDL cholesterol in the leukocyte adhesion response was assessed using human apolipoprotein A‐I transgenic mice (TGApoA1). No significant differences in leukocyte adhesion were observed between TGApoA1 mice ± HTN. Our findings indicate that moderate increases in total plasma cholesterol blunt the pro‐inflammatory phenotype that is induced in brain by DOCA‐salt HTN. Group BP (mmHg) Plasma Total Cholest. (mg/dL) HDL (mg/dL) Leukocyte Adhesion (per mm 2 ) Sham 104±2 70±3 40±4 29±12 HCh 104±1 111±11 64±6 67±24 HTN 138±2 85±5 55±2 129±15 HTN/HCh 140±3 120±7 77±6 72±9 TGApoA1 100±2 175±9 148±1 60±15 Sham HTN 118±5 258±9 212±9 110±16 TGApoA1 P&lt;0.05 vs Sham, P &lt; 0.05 vs TGApoA1 Sham. (Supported by HL26441).