gebhart/patrepeval huggingface dataset:
Quasi-Living Polymerization of N-Isopropylacrylamide onto Poly(ethylene glycol) (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTQuasi-Living Polymerization of N-Isopropylacrylamide onto Poly(ethylene glycol)M. D. C. Topp, I. H. Leunen, P. J. Dijkstra, K. Tauer, C. Schellenberg, and J. FeijenView Author Information Department of Chemical Technology and Institute for Biomedical Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands, and Max-Planck-Institute of Colloids and Interfaces, D-14424 Potsdam, Germany Cite this: Macromolecules 2000, 33, 14, 4986–4988Publication Date (Web):June 14, 2000Publication History Received20 October 1999Published online14 June 2000Published inissue 1 July 2000https://pubs.acs.org/doi/10.1021/ma9917500https://doi.org/10.1021/ma9917500rapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views562Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Ions,Micelles,Monomers,Polymerization,Thermal polymerization Get e-Alerts
Late Breaking Abstract - CRAC channel inhibition by RP3128 triggers potent anti-inflammatory effects in COPD or asthmatic patient-derived primary cells (2018)

<b>Introduction:</b> Calcium release activated calcium channels inhibitors have a potent role in treatment of autoimmune disorders. RP3128 is a novel and potent inhibitor of Calcium Release Activated Calcium (CRAC) channel activity with demonstrated efficacy in several models of immune-inflammatory disorders. The objective of this study was to assess the effect of RP3128 and combinations in attenuating inflammatory responses associated with respiratory diseases. <b>Methods:</b> Inhibition of antigen-induced cytokine release in primary T-lymphocytes was estimated. Peripheral blood neutrophils or mononuclear cells were isolated from COPD or asthmatic patients, pre-incubated with RP3128 for 0.5 h, and stimulated with 5% cigarette smoke extract (CSE) or 1 μg/ml LPS for 6 h for measurement of cytokine release. Effect of the combination of 1 μM RP3128 with 0.1 nM Fluticasone on IL-1β, IL-6, and GM-CSF release in mononuclear cells from asthmatic patients was also assessed. <b>Results:</b> Incubation with 1 nM or 1 μM RP3128 reduced IL-8 secretion by 25% and 50% respectively, in COPD patient-derived neutrophils. In asthmatic patient-derived cells, RP3128 inhibited GM-CSF, IL6 and IL1β release induced by LPS with IC<sub>50</sub> of 3.9 nM, 1.3 nM, and 10 nM, respectively. Further, addition of 1 μM RP3128 significantly (<i>P&lt;0.05</i>) potentiated fluticasone activity manifested by enhanced inhibition of LPS-induced GM-CSF, IL6, and IL1β release in cells from asthma patients. <b>Conclusions:</b> Results demonstrate the anti-inflammatory effects of RP3128 in COPD and asthmatic patient-derived primary cells thereby indicating the therapeutic potential of this molecule in respiratory disorders.
Control of Four-Magnon Scattering by Pure Spin Current in a Magnonic Waveguide (2023)

Spintronic devices have attracted strong interest in neuromorphic computing, because of their inherent nonlinear behavior and synchronization capabilities. To build magnon-based networks between spintronic oscillators acting as neurons, control mechanisms are the key to adjusting their interactions. This study uses spin-orbit torque to reduce damping and enable magnon scattering in ultrathin waveguides. Microwave power and frequency, as well as spin-current magnitude, can be used as control parameters for nonlinear generation of additional magnon modes at distinct frequencies. Field-dependent time- and space-resolved measurements expose the underlying physical process.
Characterization of Flame Behavior and Blowout Limits at Different Air Preheating Temperatures in Plasma Assisted Stabilized Combustor (2022)

Abstract This study investigates the flame characterization near to lean blowout (LBO) limits at different pre-heating temperatures in lifted swirl methane-air plasma discharge stabilized flame. The combustor was equipped with a needle-ring type plasma actuator driven by a sinusoidal generator at 20 kHz directly coupled with methane-air premixed flame close to the injector exit. The needle electrode connected with high voltage (HV) and the nozzle acted as a grounded electrode. The electrical characterizations of combustion characteristics and LBO measurements have been carried out at different plasma power, air preheating temperatures, and air mass flow rates. Flame shape and intensity in the flame area have been analyzed based on the images acquired by using a high-resolution camera. Acoustic measurements were performed using high sensitivity microphone. Furthermore, post-processing of the microphone data involved the application of Fast Fourier Transform (FFT) and the wavelet decomposition to identify and characterize any periodic phenomena present in the system. It has been perceived that when the plasma is on, LBO limits were extended significantly. The maximum reduction of equivalence ratio at LBO was noticed in terms of percentage (79.4%) at 40% voltage amplitude, T = 373 K, and ma = 6 m3/h. Proper orthogonal decomposition was implemented on the high-speed chemiluminescence images and the frequency analysis of the time coefficients of the modes of the POD permits the identification of the dominant frequency ranges in the different operating conditions. The results were in good agreement with the findings of the FFT and Wavelet analysis on the microphone measured signals.
The ARIES tokamak fusion reactor study (2003)

The Advanced Reactor Innovation and Evaluation Study (ARIES) is a community effort to develop several visions of the tokamak as a fusion power reactor. The aims are to determine its potential economics, safety, and environmental features and to identify physics and technology areas with the highest leverage for achieving the best tokamak reactor. The authors focus on the ARIES-1 design. Parametric systems studies show that the optimum first stability tokamak has relatively low plasma current ( approximately 12 MA), high plasma aspect ratio ( approximately 4-6), and high magnetic field ( approximately 24 T at the coil). ARIES-I is a 1000-MWe (net) reactor with a plasma major radius of 6.5 m, a minor radius of 1.4 m, a neutron wall loading of about 2.8 MW/m/sup 2/, and a mass power density of about 90 kWe/tonne. The ARIES-I reactor operates at steady state using ICRF (ion-cyclotron range of frequency) fast waves to drive current in the plasma core and lower-hybrid waves for edge-plasma current drive. The ARIES-I blanket is cooled by He and consists of SiC-composite structural material, Li/sub 4/SiO/sub 4/ solid breeder, and Be neutron multiplier, all chosen for their low-activation and low-decay after-heat in order to enhance the safety and environmental features of the design. The ARIES-I design has a competitive cost of electricity and superior safety and environmental features.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II (2022)

Glutamate carboxypeptidase-II (GCPII) is a zinc-dependent metalloenzyme implicated in numerous neurological disorders. The pharmacophoric requirements of active-site GCPII inhibitors makes them highly charged, manifesting poor pharmacokinetic (PK) properties. Herein, we describe the discovery and characterization of catechol-based inhibitors including L-DOPA, D-DOPA, and caffeic acid, with sub-micromolar potencies. Of these, D-DOPA emerged as the most promising compound, with good metabolic stability, and excellent PK properties. Orally administered D-DOPA yielded high plasma exposures (AUCplasma = 72.7 nmol·h/mL) and an absolute oral bioavailability of 47.7%. Unfortunately, D-DOPA brain exposures were low with AUCbrain = 2.42 nmol/g and AUCbrain/plasma ratio of 0.03. Given reports of isomeric inversion of D-DOPA to L-DOPA via D-amino acid oxidase (DAAO), we evaluated D-DOPA PK in combination with the DAAO inhibitor sodium benzoate and observed a >200% enhancement in both plasma and brain exposures (AUCplasma = 185 nmol·h/mL; AUCbrain = 5.48 nmol·h/g). Further, we demonstrated GCPII target engagement; orally administered D-DOPA with or without sodium benzoate caused significant inhibition of GCPII activity. Lastly, mode of inhibition studies revealed D-DOPA to be a noncompetitive, allosteric inhibitor of GCPII. To our knowledge, this is the first report of D-DOPA as a distinct scaffold for GCPII inhibition, laying the groundwork for future optimization to obtain clinically viable candidates.
Effects of a variable linewidth laser and variable linewidth shape laser on coherent FMCW LiDAR (2023)

To investigate the tolerance of laser linewidth, a stable and variable light source is essential. This study proposes a novel method for generating a variable linewidth and variable light source using a lithium niobite phase modulator, achieved through the application of white Gaussian noise and random walk noise with a limited wall. The proposed approach was thoroughly examined through equations, simulations, and experiments. Further, a practical application was demonstrated while investigating the effects of variable linewidth and shape on FMCW LiDAR performance. The results highlight the importance of optimizing the light source for LiDAR applications to ensure the maximum accuracy and resolution.
OS0707-472 Strain Measurements for Mineral and Collagen in Cortical Bone by Small and Wide Angle X-ray Diffraction (2015)

Bone is often regarded as a composite material consisting of mineral particles and organic matrix (mostly Type I collagen) on a microscopic scale. The mechanical properties of bone tissues at a macroscopic scale depend on the structural organization and properties of constituents in the microscopic scale. However, both mechanical behaviors of mineral and collagen phases are not clear yet. In this study, both microscopic strain of collagen and mineral phases in cortical bone by using small and wide angle X-ray diffraction, respectively. The collagen matrix strain allowed tensile deformation as compared with mineral phase. This study could suggest that macroscopic mechanical properties of bone tissue depend on the degree of deformation of mineral and collagen matrix.
Near point convergence and other measures of vestibulo-ocular dysfunction are associated with protracted neurological recovery after sports concussion (2017)

Objective To characterise specific measures of neurologic dysfunction and recovery associated with concussion in student-athletes using the clinical examination and Cleveland Clinic Concussion application (C3 app). Design Retrospective observational study Setting Tertiary sports concussion clinic Participants 181 student-athletes aged 14-20 diagnosed with concussion by a Cleveland Clinic physician were included. Interventions C3 data were collected pre-season, and at least once post-injury, along with a physician clinical examination. Individuals were stratified into two groups based on recovery time: typical &lt;21 days (n=97) or protracted 21+ days (n=84). Outcome measures Near point convergence (NPC) and the following modules of the C3 app were administered: 1) Graded symptom checklist (GSC); 2) Standardised Assessment of Concussion (SAC); 3) Trail Making Test (TMT); 4) Simple and Choice Reaction Time; 5) Processing Speed Test (PST); 6) Biomechanical quantification of balance during the BESS. Main results At baseline, both groups performed similarly on all C3 modules. Significant differences in NPC were seen among the typical versus protracted group (mean 7.62 cm versus 13.57 cm, p=0.0002). Also, significantly worse performance among the protracted group was seen in GSC (p=0.0001), and measures affected by vestibulo-ocular dysfunction including biomechanical quantification of BESS (p&lt;0.05), simple and choice reaction time (p&lt;0.001), and TMT-B (p=0.01). No difference between groups was noted in BESS errors, SAC, or PST. Conclusions Abnormal NPC or convergence insufficiency is associated with protracted recovery and should be included in the assessment of student-athletes at baseline and post-injury. Identification of vestibulo-ocular dysfunction helps guide post-concussion assessment, treatment, and return-to-play decision-making. Competing interests Bob Gray, Rick Figler, Jason Cruickshank, Maureen Lally, Tanujit Day: None. Susan Linder and Jay Alberts have authored intellectual property associated with the mobile application presented in this study.
Study of Protection by Recombinant Fowl Poxvirus Expressing C-Terminal Nucleocapsid Protein of Infectious Bronchitis Virus against Challenge (2001)

A stable recombinant fowl poxvirus (rFPV) expressing the C-terminal region (119 amino acids) of the nucleocapsid (N) protein of an infectious bronchitis virus (IBV) strain Ch3 was constructed by inserting the coding sequence within the thymidine kinase gene of fowl poxvirus (FPV) by homologous recombination. The N protein was expressed under control of the vaccinia virus promoter P7.5 in chicken embryo fibroblast cell cultures as seen in immunofluorescence assay and in rFPV-inoculated specific-pathogen-free (SPF) chickens by detecting antibodies with enzyme-linked immunosorbent assay (ELISA). A homologous IBV strain (Ch3) and two heterologous IBV strains (Ch5 and H4) were used to inoculate SPF chickens in a challenge to examine the protective efficacy of the rFPV. When the chickens were challenged with IBV Ch3 or Ch5, the control birds had respiratory signs of infections bronchitis, whereas all the vaccinated birds were clinically normal although low levels of the IBV infection were detected by a differential ELISA. In contrast, in the chickens challenged with IBV H4, all control birds and vaccinated birds suffered from the highly lethal IBV H4 infection. Our results suggest that the C-terminal 119 amino acid of the nucleocapsid expressed by FPV is a host-protective antigen and may induce cross-protective immunity against illness among some IBV strains.
Secure Separation of Shared Caches in AMP-Based Mixed Criticality Systems (2015)

The secure separation of functionality is one of the key requirements particularly in mixed criticality systems (MCS). Well-known security models as the multiple independent levels of security (MILS) aim to formalise the isolation of compartments to avoid interference and make them reliable to work in safety critical environments. Especially for in-car multimedia systems, also known as In-Vehicle Infotainment (IVI) systems, the composition of compartments onto a system-on-chip (SoC) offers a wide variety of advantages in embedded system development. The development of such systems implies often the combination of pre-qualified hardware- and software components. These components are CPU subsystems and operating systems, for example. However, the required strict separation can suffer due to the pre-qualified and therefore not reconfigurable hardware components. Particularly, this is true for shared cache levels in CPU subsystems. The phenomena of interference in the concurrent usage of shared last-level caches, are exploitable by adversaries. Therefore, this article identifies the attack surface and proposes a mitigation to prevent from the intentional misuse of the fixed cache association. Generally, the solution is based on a suitable mapping scheme in the intermediate address space of an asymmetric multiprocessing environment which implements the MCS. Furthermore, we evaluate the strength of the approach and show how the solution contributes to a separation property conformal system.
Material glass transition temperature, device thickness, and operational temperature effects on absorption of electro-optic polymer films (2000)

In chromophore doped materials, the trade-off between nonlinear coefficients and absorption is a critical issue. In particular, X<SUP>(2</SUP>):X<SUP>(2</SUP>) cascading based applications at 1.55 micrometers impose stringent conditions on the absorption at the second-harmonic wavelength. Transmission spectroscopy through a thin film does not provide sufficient resolution to measure the absorption coefficient on the red side of the main absorption band. However, assuming Voigt profiles, it is possible to extrapolate the absorption coefficient in the near infrared (NIR) from the main electronic resonance. We report on the dramatic impact of the host polymer matrix on the near infrared absorption of azobenzene chromophores. The effect is directly correlated to the host polymer glass transition temperature. The case of hybrid sol-gel material is also discussed. In particular, we present here an interesting correlation between the poling temperature and some spectroscopic properties. This correlation and thermo- spectroscopic measurements lead us to define an effective T<SUB>g</SUB> in the sol-gel system. We also report on film thickness dependent absorption properties.
Diagnosis in Oncology. Leukemia cutis. (1997)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1997.15.5.2170 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9164232 Diagnosis in Oncology. Leukemia cutis. W C HahnxW C HahnSearch for articles by this author , D JonesxD JonesSearch for articles by this author , P LeavittxP LeavittSearch for articles by this author , J GarberxJ GarberSearch for articles by this author , R StonexR StoneSearch for articles by this author , A T SkarinxA T SkarinSearch for articles by this author Show More Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston. MA, USA. https://doi.org/10.1200/JCO.1997.15.5.2170 PDF "Diagnosis in Oncology. Leukemia cutis.." Journal of Clinical Oncology, 15(5), pp. 2170–2171© 1997 by American Society of Clinical Oncology
32.1: Invited Paper : A Comparison of Pixel Circuits for Active Matrix Polymer/Organic LED Displays (2002)

Abstract In this paper measurements on several types of active matrix polymer LED (AMPLED) displays will be presented. The issues ofimage uniformity and polymer aging will be addressed by pixel circuit designs.
Photonic integration using asymmetric twin-waveguide (ATG) technology: part I-concepts and theory (2005)

In this first of two papers (hereinafter called Paper I), we present a universal approach for simply realizing monolithic photonic integration based on asymmetric twin-waveguide (ATG) technology. The concepts and important developments leading to ATG integration technology will be reviewed. The ATG structure consists of active and/or passive devices formed in separate, vertically displaced waveguides. Light is transferred between the waveguides via very low loss, lateral, adiabatic tapered mode transformers, allowing different optical functions to be realized in the different waveguides. The design of the adiabatic tapered mode transformer uses an algorithm based on perturbation theory. We show that the same designs can also be deduced from coupled local mode theory. Using the perturbation algorithm to design the taper coupler in an ATG based high bandwidth photodiode, a transfer efficiency of greater than 90% from the fiber waveguide to the coupling waveguide is achieved while the taper length can be reduced by 35% compared to conventional two-section linear taper couplers. The taper design algorithm is further optimized to make the adiabatic taper couplers tolerant to variations in incident light polarization, operation wavelength, and dimensional control during fabrication. Finally, we propose and design a taper that adiabatically couples light from the fundamental mode to the first-order mode. Such a taper coupler is useful in an integrated semiconductor optical amplifier/p-i-n detector circuit.
Liquid interface evolution of polyhedral-like graphene (2015)

Centrifugation of the graphene oxide mediated Pickering emulsion results in transforming spheroidal toluene droplets into irregular polyhedral shapes, which can be preserved into a solid three-dimensional polyhedral-like graphene oxide network featuring facets and sharp edges, using a freeze-drying strategy.
ACM WSDM 2022 report (2022)

The 15 th ACM International Conference on Web Search and Data Mining (WSDM 2022) was successfully held on 2/21 - 2/25/2022 online. It was originally planned to be held in Tempe, Arizona and changed to a virtual format due to the surge of Omicron. It was a five-day event with the middle 3 days dedicated to keynote speeches, single-session presentations, poster sessions, and sponsor talks. This brief report provides an overview of WSDM 2022 with organization and program details and statistics from Conference Chairs and Program Committee Chairs, as well as a message from the WSDM Steering Committee Chair to call for future WSDM conferences in the US (2024) and Europe (2025). Further details can be found at https://www.wsdm-conference.org/2022/. At the end of this report, we express our deep gratitude to authors, volunteers, special interest groups (SIGs), steering committee, and sponsors.
Flux pump excited brushless alternator (1981)

Experimental measurements obtained for a novel brushless superconducting alternator that makes use of a flux pump of the rotating spot type are presented. The flux pump, used to provide the excitation current of the field coils incorporates several features of a machine studied theoretically and reported in an earlier paper. The flux pumping is achieved with six electromagnets having pole pieces of special configurations to yield high efficiency and rapid pumping rates. The maximum design values for the current in the pump is 1,300 amps. and for the rotational speed, 500 rpm. Sensors installed on the generator yield information on the spatial and temporal behavior of the magnetic field in the flux spot and on the operational characteristics of the pump. The preliminary observations are compared with the theoretical predictions.