gebhart/patrepeval huggingface dataset:
Synthese, structures et proprietes magnetiques de phosphonates de metaux divalents (1994)

Ce memoire presente l'etude de la chimie et des proprietes magnetiques statiques d'organophosphonates de metaux de transition divalents (mn, fe, co, ni, cu, zn). Dans la plupart des cas, la formule est du type m#i#i(rpo#3), xh#2o, ou m est le metal divalent, r un radical n-alkyl, phenyl ou tert-butyl, x pouvant varier de 0 a 1. La premiere partie presente les differents modeles structuraux rencontres. Les feuillets des composes du mn, co, ni, zn sont isostructuraux; ils sont lamellaires, et la distance interfeuillet est modulee par le choix du radical organique. Les composes du cuivre, bien que le plus souvent lamellaires, presentent une structure de feuillet differente, en relation avec la stereochimie particuliere du cuivre. Une exception a ces composes bidimensionnels est rencontree pour le methylphosphonate de cuivre anhydre, le seul phosphonate non fonctionnalise presentant une structure en canaux. L'etude des proprietes magnetiques de l'ethylphosphonate a revele un comportement antiferromagnetique bidimensionnel. Nous avons tente d'extraire des informations sur l'anisotropie de ce compose a partir d'echantillons textures. L'influence de l'anisotropie au-dessus et en-dessous de t#n a ainsi pu etre demontree. Les autres organophosphonates presentent aussi un comportement antiferromagnetique de basse dimensionnalite. Des specificites liees a chaque metal sont relevees, la temperature d'ordre etant independante du radical choixi. Cette etude donne une meilleure connaissance des phosphonates de metaux divalents, et permet de progresser dans l'objectif d'utiliser les matrices phosphonates comme supports de centre catalytique
[Mechanisms and control of meiotic recombination in the yeast Saccharomyces cerevisiae]. (1999)

Recent studies in Saccharomyces cerevisiae have provided new insights in our understanding of the molecular mechanisms of meiotic recombination. Meiosis-specific DNA double-strand breaks have been detected and have been shown to be the lesions that initiate recombination events. These are located mostly in promoter regions where the chromatin is in an open configuration, and cluster in domains along the chromosome. They are likely to be made by a topoisomerase II-like protein encoded by the SPO11 gene. Several DNA intermediates in the meiotic double strand-break repair pathway have been characterised and several multi-protein complexes have been identified and shown to be involved at different steps in the repair pathway. The conservation of these protein complexes in higher eukaryotes suggests that the meiotic recombination mechanism could be conserved. With the application of the well characterised genetical, molecular, cytological and biochemical techniques and the recently developed technology for genomic studies (biochips), we can expect a rapid increase in our comprehension of the meiotic recombination process.
Distributed Access Control for Carrier Class Clusters. (2003)

The telecommunication industry traditionally uses clusters to meet its carrier-class requirements of high availability and reliability. As security has also become a major issue, a Distributed Security Infrastructure (DSI) has been initiated for carrier-class Linux clusters. DSI is a security framework which focuses on providing distributed security services and simplifying security administration. This paper presents one of those services: distributed access control service (DisAC). This service manages access rights throughout the whole cluster with process-level granularity. Rules are configured through a unique security policy, which is propagated to each node of the cluster. DisAC enhances this policy at node level but also inter-node access control with process-level granularity.
Sensitivity of Surface Acoustic Wave Magnetic Sensors Composed of Various Ni Electrode Structures (2012)

A shear horizontal type of surface acoustic wave (SAW) magnetic sensor composed of a magnetostrictive Ni electrode and an ST-cut 90°X quartz substrate was fabricated. In this study, in order to obtain a higher magnetic sensitivity, one-port SAW resonators composed of three kinds of Ni electrode structures on the ST-cut 90°X quartz, namely, (a) grooved Ni electrodes, (b) additional overlaid Ni films on grooved Ni electrodes, and (c) Ni electrodes on the quartz, were fabricated and measured. In addition to these, a SAW resonator composed of a magnetostrictive TbFe 2 film electrode, which has a larger magnetostrictivity than the Ni film, on the ST-cut 90°X quartz was also fabricated. Their characteristics are examined.
Single Cell Transcriptional Archetypes of Airway Inflammation in Cystic Fibrosis (2020)

Abstract Cystic fibrosis (CF) is a life-shortening multisystem hereditary disease caused by abnormal chloride transport. CF lung disease is driven by innate immune dysfunction that perpetuates inflammation. The airways provide a window into CF pathogenesis, as immune cells display exaggerated inflammatory responses and impaired phagocytic function, contributing to tissue injury. In order to define the transcriptional profile of this airway immune dysfunction, we performed the first single-cell transcriptome characterization of CF sputum. We show that the airway immune cell repertoire shifted from alveolar macrophages in HC to a predominance of recruited monocytes and neutrophils in CF. Recruited lung mononuclear phagocytes were abundant in CF, separated into three archetypes: activated monocytes, monocyte-derived macrophages, and heat-shock activated monocytes. Neutrophils were most prevalent in CF, with a dominant immature proinflammatory archetype. While CF monocytes exhibited proinflammatory features, both monocytes and neutrophils showed transcriptional evidence of abnormal phagocytic and cell-survival programs. Our findings offer an opportunity to understand subject-specific immune dysfunction and its contribution to divergent clinical courses in CF. As we progress towards personalized applications of therapeutic and genomic developments, we hope this inflammation profiling approach will enable further discoveries that change the natural history of CF lung disease.
Use of a diabetes-specific nutritional shake to replace a daily breakfast and afternoon snack improves glycemic responses assessed by continuous glucose monitoring in people with type 2 diabetes: a randomized clinical pilot study (2020)

NCT04230889.
EX VIVO INTERFERON-GAMMA IMMUNE RESPONSE TO THROMBOSPONDIN-RELATED ADHESIVE PROTEIN IN COASTAL KENYANS: LONGEVITY AND RISK OF PLASMODIUM FALCIPARUM INFECTION (2003)

Thrombospondin-related adhesive protein (TRAP) of Plasmodium falciparum is currently being tested in human vaccine studies. However, its natural reactivity in the field remains poorly characterized. More than 40% of 217 Kenyan donors responded in an ex vivo interferon-gamma (IFN-gamma) enzyme-linked immunospot (ELISPOT) assay to at least one of 14 20mer peptides spanning 42% of the antigen. Reactivity was comparable from early childhood (>1 year of age) to old age, and the maximal precursor frequency of TRAP-specific cells to all 14 peptides was 1 in 4,000. Prospective follow-up for one year indicated that these low-level ex vivo responses to TRAP did not protect against the subsequent development of malaria. Retesting of selected donors after one year showed a complete change in the reactivity pattern, suggesting that malaria-specific ex vivo IFN-gamma ELISPOT assay responses are short lived in naturally exposed donors, even to conserved epitopes. This study provides important information regarding natural reactivity to a key malaria antigen.
Measurement of the Hubble constant and peculiar velocities of clusters using the Sunyaev-Zel'dovich effect (1995)

The thermal and kinematic components of the S-Z effect have distinct spectral shapes and can be separated by measurements at two or more mm wavelengths. We have made measurements of the Sunyaev-Zel'dovich (S-Z) effect at mm wavelengths with the specific goals of determining the value of the Hubble Constant, H_0, and the peculiar velocities of galaxy clusters, vpec. In a band centered at 2.1mm, we have detected a decrement in the brightness of the Cosmic Microwave Background (CMB) in the direction of A2163 (z=.20) with a significance of greater than 10 sigma . By comparing the morphology of the S-Z and low energy X-ray surface brightnesses we have constrained models for the thermal structure of the intracluster (IC) gas. We determine, in general agreement with recent ASCA results, that the IC gas temperature decreases beyond 3 core radii. When uncertainties due to peculiar velocity, astrophysical confusion, IC gas temperature, clumping and asphericity of the IC gas are taken into account, we determine H_0(q_0=(1)/(2)) = 72.6(+47}_{-33) kms(-1}Mpc({-1)) . In a band centered at 1.1mm, we have made the first significant detection of a brightness increment due the S-Z thermal effect. We have observed this cluster in a third band centered at 1.4mm; combining all the data we are able to limit the peculiar velocity to vpec = -400(+810}_{-990) kms(-1) . Measurements of the cluster A1689 (z=.18) in the 2.1mm and 1.4mm bands have been used to limit its peculiar velocity to vpec = -360(+510}_{-690) kms(-1) .
Green and Ultraviolet Pulse Generation Using a Low-Repetition-Rate Mode-Locked Yb-Doped Fiber Laser (2007)

Using a compact 1-mμ mode-locked fiber source, we demonstrate 2nd harmonic generation (540nm) of 0.4 W and 4th harmonic generation (270nm) of 0.1 W with subpicosecond pulse durations.
Uniform Nano-Sn/C Composite Anodes for Lithium Ion Batteries (2013)

Nano-Sn/C composites are ideal anode materials for high energy and power density Li-ion batteries. However, because of the low melting point of Sn and the tendency of grain growth, especially during high temperature carbonization, it has been a significant challenge to create well-dispersed ultrasmall Sn nanoparticles within a carbon matrix. In this paper, we demonstrate an aerosol spray pyrolysis technique, as a facile and scalable method, to synthesize a nano-Sn/C composite with uniformly dispersed 10 nm nano-Sn within a spherical carbon matrix. The discharge capacity of nano-Sn/C composite sphere anodes maintains the initial capacity of 710 mAh/g after 130 cycles at 0.25 C. The nano-Sn/C composite sphere anodes can provide ~600 mAh/g even at a high rate of 20 C. To the best of our knowledge, such high rate performance for Sn anodes has not been reported previously. The exceptional performance of the nano-Sn/C composite is attributed to the unique nano-Sn/C structure: (1) carbon matrix offers mechanical support to accommodate the stress associated with the large volume change of nano-Sn, thus alleviating pulverization; (2) the carbon matrix prevents Sn nanoparticle agglomeration upon prolonged cycling; and (3) carbon network provides continuous path for Li ions and electrons inside the nano-Sn/C composite spheres.
Poster Session 3: Friday 9 December 2011, 08:30-12:30 * Location: Poster Area (2011)

Background: Left atrial (LA) size and function are well-known predictors of cardiovascular outcome. Our aim was to evaluate age-related changes in LA volumes and function in healthy subjects using a novel prototype 3D software dedicated for atrium quantitation. Methods: 65 healthy volunteers aged 18 to 65 (38+12 years, 34 men) and good acoustic window underwent 3D LA full-volume acquisition from apical approach (31+6 vps). LA data sets were analyzed with a semi-automated software (TomTec, Unterschleissheim, D). LA volumes (LAV max; min; preA = LAV before LA contraction) and LA function indexes were provided. Results: LA indexes derived from a single 3D LA data set analysis (average time 4′10′′) are summarized in Table. Age was positively correlated with all LA volumes (LAV max r=0.32, min r=0.30, preA r=0.42, p,0.02 for all). Both active and total LA ejection fraction were marginally correlated with age (r=-0.24 and r=0.24, p=0.05 for both). LA active stroke volume increased with ageing (r=0.43, p,0.001), the active LA contribution ranging from 26+8% of total LA stroke volume in subjects ,30 years to 35+10% in subjects .50 years (p ANOVA=0.02). Conversely, LA total stroke volume or LA sphericity were not age-related. Intraclass correlation coefficients for LAV max, min and preA were 0.98, 0.93, 0.94 for intraobserver and 0.82, 0.66, 0.80 for interobserver reproducibility, respectively. Conclusions: The tested software dedicated for LA quantitation on 3D data sets works fairly rapid and reproducible, enabling the detection of age-related changes in LA size and function. Reference values are provided for clinical testing of this new LA software
A Proposal for Applying Belief, Desire, and Intent Agents toward Automotive Vehicle Energy Management (2020)

&lt;div&gt;The automotive industry is facing a multifaceted problem of supervisory energy management, computational power, and digitalization. In response, this article proposes the use of agents utilizing the belief, desire, and intent (BDI) framework as a means to flexibly create online vehicle management systems (VMSs). Under such proposal, a community of agents form a vehicle configuration. Each agent represents a vehicle subsystem and contains knowledge specific to its respective hardware. With this knowledge and partial observation over its operating environment, each agent uses the BDI framework to deliberate over its actions. An interaction protocol, which implements a distributed constraint satisfaction problem (DCSP) algorithm, is used between the agents to create sensible emergent behavior of the vehicle. This interaction protocol allows independently reasoning components to produce emergent behavior that is flexible, robust, verifiable, and explainable. In addition, an internal structure on top of the BDI framework is specified which allows an agent to conduct long-term and short-term deliberation asynchronously. A simple, parallel hybrid electric vehicle model is used to demonstrate the application of BDI agents. The agents are tested over the vehicle’s operating envelope to show how independent deliberation and the interaction protocol results in expected behavior and undesirable interactions are avoided. By using agents as modular components, features like dynamic vehicle configurations and persistent intentions are achieved. This article lays the foundation for further studies in the field of applying agents to automotive vehicle control.&lt;/div&gt;
Coupling a Basin Modeling and a Seismic Code using MOAB (2012)

We report on a demonstration of loose multiphysics coupling between a basin modeling code and a seismic code running on a large parallel machine. Multiphysics coupling, which is one critical capability for a high performance computing (HPC) framework, was implemented using the MOAB open-source mesh and field database. MOAB provides for code coupling by storing mesh data and input and output field data for the coupled analysis codes and interpolating the field values between different meshes used by the coupled codes. We found it straightforward to use MOAB to couple the PBSM basin modeling code and the FWI3D seismic code on an IBM Blue Gene/P system. We describe how the coupling was implemented and present benchmarking results for up to 8 racks of Blue Gene/P with 8192 nodes and MPI processes. The coupling code is fast compared to the analysis codes and it scales well up to at least 8192 nodes, indicating that a mesh and field database is an efficient way to implement loose multiphysics coupling for large parallel machines.
The A? oligomer count in CSF is a useful biomarker for Alzheimer?s disease (2014)

A disease (AD) is a fatal neurodegenerative and progressive disorder. Currently, no reliable biomarkers for presymptomatic diagnosis or therapy monitoring are available. Recent studies indicate that especially soluble amyloid beta peptide (Aβ) oligomers are the major toxic species during development and progression of AD. Therefore, we suggest that the number of Aβ oligomers in body fluids can be used as the most relevant and direct biomarker for AD. We developed a surfacebased fluorescence intensity distribution analysis (sFIDA) assay for specific quantification of Aβ oligomers with single particle sensitivity. We challenged the assay with cerebrospinal fluid (CSF) samples from 14 AD patients and 12 age-matched control subjects. The Aβ oligomer count revealed a surprisingly clear distinction between both groups. All samples of the control group showed homogenously low numbers of Aβ oligomers, while the samples of the AD group exhibited significantly higher levels of Aβ oligomers. The Aβ oligomer levels clearly correlated with the patients’ mini-mental state examination (MMSE) scores. Our results support the idea that Aβ oligomers play a crucial role in AD pathology and in turn can be used as a diagnostic biomarker. The sFIDA assay is able to reliably and specifically quantify Aβ oligomers in human CSF. In addition, the correlation between MMSE scores and Aβ oligomer concentrations in CSF suggests that the quantity of Aβ oligomers in CSF correlates with the severity of the disease. This will allow to evaluate and to monitor anti-Aβ-targeted therapies based on the Aβ oligomer counts in treated individuals.
Data from YAP1 and COX2 Coordinately Regulate Urothelial Cancer Stem-like Cells (2023)

&lt;div&gt;Abstract&lt;p&gt;Overcoming acquired drug resistance remains a core challenge in the clinical management of human cancer, including in urothelial carcinoma of the bladder (UCB). Cancer stem-like cells (CSC) have been implicated in the emergence of drug resistance but mechanisms and intervention points are not completely understood. Here, we report that the proinflammatory COX2/PGE2 pathway and the YAP1 growth-regulatory pathway cooperate to recruit the stem cell factor SOX2 in expanding and sustaining the accumulation of urothelial CSCs. Mechanistically, COX2/PGE2 signaling induced promoter methylation of let-7, resulting in its downregulation and subsequent SOX2 upregulation. YAP1 induced SOX2 expression more directly by binding its enhancer region. In UCB clinical specimens, positive correlations in the expression of SOX2, COX2, and YAP1 were observed, with coexpression of COX2 and YAP1 particularly commonly observed. Additional investigations suggested that activation of the COX2/PGE2 and YAP1 pathways also promoted acquired resistance to EGFR inhibitors in basal-type UCB. In a mouse xenograft model of UCB, dual inhibition of COX2 and YAP1 elicited a long-lasting therapeutic response by limiting CSC expansion after chemotherapy and EGFR inhibition. Our findings provide a preclinical rationale to target these pathways concurrently with systemic chemotherapy as a strategy to improve the clinical management of UCB.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Significance:&lt;/b&gt; These findings offer a preclinical rationale to target the COX2 and YAP1 pathways concurrently with systemic chemotherapy to improve the clinical management of UCB, based on evidence that these two pathways expand cancer stem-like cell populations that mediate resistance to chemotherapy. &lt;i&gt;Cancer Res; 78(1); 168–81. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
MicroRNAs contribute to postnatal development of laminar differences and neuronal subtypes in the rat medial entorhinal cortex (2017)

The medial entorhinal cortex (MEC) is important in spatial navigation and memory formation and its layers have distinct neuronal subtypes, connectivity, spatial properties, and disease susceptibility. As little is known about the molecular basis for the development of these laminar differences, we analyzed microRNA (miRNA) and messenger RNA (mRNA) expression differences between rat MEC layer II and layers III-VI during postnatal development. We identified layer and age-specific regulation of gene expression by miRNAs, which included processes related to neuron specialization and locomotor behavior. Further analyses by retrograde labeling and expression profiling of layer II stellate neurons and in situ hybridization revealed that the miRNA most up-regulated in layer II, miR-143, was enriched in stellate neurons, whereas the miRNA most up-regulated in deep layers, miR-219-5p, was expressed in ependymal cells, oligodendrocytes and glia. Bioinformatics analyses of predicted mRNA targets with negatively correlated expression patterns to miR-143 found that miR-143 likely regulates the Lmo4 gene, which is known to influence hippocampal-based spatial learning.
A novel scheme to interconnect multiple frequency hopping channels into an ad hoc network (2004)

Frequency hopping radios have very attractive features to be used as PAN links, but their use in ad hoc networking is problematic because of the difficulty to synchronize the channels and coordinate transmission attempts. We propose a novel mechanism to interconnect multiple frequency hopping channels into an ad hoc network based on an adapted version of CSMA/CA. The performance of the proposal is investigated using analytical and simulation tools. By using multiple channels, we achieve significant improvement in aggregate throughput despite the penalty of switching between channels. We show how this performance penalty can be decreased by grouping devices based on the traffic pattern.
Benefits of SiF/sub 3//sup +/ implanted titanium silicides in advanced CMOS fabrication (2002)

We present, for the first time, dramatic improvements in the titanium silicide quality by adding SiF/sub 3//sup +/ mixing implantation in advanced CMOS SALICIDE (Self-aligned silicide) process. We obtained 4/spl times/ reduction in contact resistance and an extremely tight distribution (/spl sigma/-0.09 /spl Omega/) for N+, P+, N-poly, and P-poly contacts. Due to the introduction of fluorine in this process, we observed that the Gm degradation after 500 s constant voltage stressing is improved by 12/spl times/ for SiF/sub 3//sup +/ implanted silicided MOSFET. The silicides with SiF/sub 3//sup +/ mixing implantation have very unique properties compared with other mixing implantation using atomic species alone. This technique will improve the circuit performance, reliability, and yield in advanced CMOS process.
AlphaFold Models Illuminate Half of Dark Human Proteins (2021)

ABSTRACT We investigate the use of confidence scores to predict the accuracy of a given AlphaFold model for drug discovery. Predicted accuracy is improved by eliminating confidence scores below 80, due to effects of disorder. 95% of models corresponding to a set of recent crystal structures are accurate at the fold level. Conformational discordance in the training set has a more significant effect on accuracy than sequence divergence. We propose criteria for models and residues that are possibly useful for virtual screening, by which AlphaFold provides models for half of understudied (dark) human proteins and two-thirds of residues in those models.