gebhart/patrepeval huggingface dataset:
Design of Contour Based Protection Zones for Sublicensing in Spectrum Access Systems (2017)

Spectrum Access System (SAS) allows incumbent military systems to share spectrum in a hierarchical manner with tier-2 Priority Access License (PAL) users and tier-3 General Authorized Access (GAA) users. FCC has recently allowed PAL owners to sublicense their channels. Therefore, when GAA channels are congested they can request a sublicense to access the PAL channel on a coordinated basis, which provides interference protection from other GAA users. In this paper, we propose a grid map to measure and monitor the secondary spectrum market for the purpose of spectrum trading with QoS guarantee. This work provides the subsequent spectrum trading models with a reasonable and dedicated interference graph for further optimization of spectrum allocation. Compared with traditional longterm spectrum licensing policy, short-term licensing makes the spectrum allocated effectively. We find the optimal resolution of the discrete grid map that maximizes the profit from sublicensing. Simulation results are provided to demonstrate how fine to grid the region and let the PAL owner achieve monetary benefit, in a given number of sensors.
Abstract 18444: Effects of Cardiac Resynchronization Therapy on Transcardiac Metabolomic Profile and Substrate Utilization (2011)

Introduction: Cardiac remodeling in heart failure (HF) is associated with conduction abnormalities and dyssynchrony which results in poorly coordinated contractions precipitating metabolic heterogeneity and energetic inefficiency. Cardiac resynchronization therapy (CRT) improves HF symptoms, ventricular function and overall survival. The aim of this study was to determine the changes in metabolomic profiles and substrate utilization after CRT. Methods: 18 patients with advanced HF and 7 healthy controls were included in this study. Blood samples were collected from peripheral vein, femoral artery (FA) and coronary sinus (CS) before and 10-min after CRT. Metabolomic profiling of plasma samples were performed using GC/MS and 1 H NMR spectroscopy. Partial Least Squares Discriminant Analysis (PLS-DA) score plots and regression coefficients were used to examine metabolomic profiles. Results: HF patients have altered plasma metabolomic profile (Fig. A) with distinct panel of metabolites including free fatty acids (FFA), glycerol, 2-hydroxybutyrate, glycine, succinate and uric acid important in group classification compared to controls. Increased release of fumarate and glycerol-3-phosphate from myocardium in HF indicate mitochondrial and substrate shuttle dysfunction. Immediately after CRT, transcardiac metabolomic profile of plasma from CS shifted to a different state with increased myocardial uptake and metabolism of FFA and decreased release of creatinine indicating improved energetic conditions (Fig. B). Conclusion: Metabolomic profiling indicates that CRT improves myocardial substrate metabolism and utilization in patients with advanced HF.
The UCI Seldinger Technique for Percutaneous Renal Cryoablation: Protecting the Tract and Achieving Hemostasis (2009)

A modified Seldinger technique enabled us to perform percutaneous renal cryotherapy through a single access channel, which facilitated access for biopsy, cryoprobe placement, and instillation of hemostatic agents. This approach may provide a protective barrier against cryogenic damage to neighboring tissues and could theoretically help minimize the chance of tract seeding.
Evaluating the Potential of Drone Swarms in Nonverbal HRI Communication (2020)

Human-to-human communications are enriched with affects and emotions, conveyed, and perceived through both verbal and nonverbal communication. It is our thesis that drone swarms can be used to communicate information enriched with effects via nonverbal channels: guiding, generally interacting with, or warning a human audience via their pattern of motions or behavior. And furthermore that this approach has unique advantages such as flexibility and mobility over other forms of user interface.In this paper, we present a user study to understand how human participants perceived and interpreted swarm behaviors of micro-drone Crazyflie quadcopters flying three different flight formations to bridge the psychological gap between front-end technologies (drones) and the human observers' emotional perceptions. We ask the question whether a human observer would in fact consider a swarm of drones in their immediate vicinity to be nonthreatening enough to be a vehicle for communication, and whether a human would intuit some communication from the swarm behavior, despite the lack of verbal or written language.Our results show that there is statistically significant support for the thesis that a human participant is open to interpreting the motion of drones as having intent and to potentially interpret their motion as communication. This supports the potential use of drone swarms as a communication resource, emergency guidance situations, policing of public events, tour guidance, etc.
Infrared Laser Desorption/Ionization on Silicon (2002)

Laser desorption/ionization from a single-crystal silicon surface was performed using a laser operating in the 3-microm region of the mid-infrared. Analyte molecules up to 6 kDa were ionized with no added matrix. As with ultraviolet desorption/ionization from porous silicon (DIOS), IR laser desorption from silicon does not produce matrix ions that can interfere with analysis of low-mass analytes. However, in contrast to UV DIOS, silicon porosity or roughness is not required for ionization using an IR laser. Mass spectra were obtained in the wavelength range between 2.8 and 3.5 microm, which is consistent with energy absorption by a hydrogen-bonded OH group. A mechanism based on desorption of adsorbed solvent molecules is postulated.
Strukturaufklärung, Totalsynthese, In‐Vivo‐Aktivität und Potentieller Biosyntheseweg des Neuen Myxobakteriellen Antibiotikums Corramycin** (2022)

Abstract Im Folgenden beschreiben wir das aus dem Myxobakterium Corallococcus coralloides isolierte Antibiotikum Corramycin. Die lineare Peptidstruktur enthält eine bislang unbeschriebene (2 R ,3 S )‐γ‐ N ‐Methyl‐β‐hydroxyhistidin‐Einheit. Corramycin weist eine anti‐Gram‐negative Aktivität gegen Escherichia coli ( E. coli ) auf und wird über zwei Tansportersysteme, SbmA und YejABEF, in die Zelle aufgenommen. Darüber hinaus wurde das Corramycin Biosynthese‐Gencluster (BGC) identifiziert und ein Biosyntheseweg bestimmt, welcher auf einer 12‐modularen nicht‐ribosomale Peptidsynthetase/Polyketidsynthase beruht. Die bioinformatische Analyse des BGC in Verbindung mit der Entwicklung einer Totalsynthese ermöglichte die Aufklärung der absoluten Konfiguration des Moleküls. Außerdem führte die intravenöse Verabreichung von 20–30 mg Corramycin pro kg Mausgewicht in einem E. coli ‐Infektionsmodell zu einer 100 %igen Überlebensrate der Tiere ohne toxische Nebenwirkungen. Somit ist Corramycin ein vielversprechender Ausgangspunkt für die Entwicklung eines wirksamen antibakteriellen Arzneimittels gegen Krankenhausinfektionen.
ChemInform Abstract: Silver Trifluoride: Preparation, Crystal Structure, Some Properties, and Comparison with AuF3. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Fault-Tolerant Clustering in Ad Hoc and Sensor Networks (2006)

In this paper, we study distributed approximation algorithms for fault-tolerant clustering in wireless ad hoc and sensor networks. A k-fold dominating set of a graph G = (V,E) is a subset S of V such that every node v \in V \ S has at least k neighbors in S. We study the problem in two network models. In general graphs, for arbitrary parameter t, we propose a distributed algorithm that runs in time O(t^2) and achieves an approximation ratio of O(t\delta^2/t log\delta), where n and \delta denote the number of nodes in the network and the maximal degree, respectively. When the network is modeled as a unit disk graph, we give a probabilistic algorithm that runs in time O(log log n) and achieves an O(1) approximation in expectation. Both algorithms require only small messages of size O(log n) bits.
Correlating antimicrobial activity and model membrane leakage induced by nylon-3 polymers and detergents (2015)

Most antimicrobial peptides act upon target microorganisms by permeabilizing their membranes. The mode of action is often assessed by vesicle leakage experiments that use model membranes, with the assumption that biological activity correlates with the permeabilization of the lipid bilayer. The current work aims to extend the interpretation of vesicle leakage results and examine the correlation between vesicle leakage and antimicrobial activity. To this end, we used a lifetime-based leakage assay with calcein-loaded vesicles to study the membrane permeabilizing properties of a novel antifungal polymer poly-NM, two of its analogs, and a series of detergents. In conjunction, the biological activities of these compounds against Candida albicans were assessed and correlated with data from vesicle leakage. Poly-NM induces all-or-none leakage in polar yeast lipid vesicles at the polymer's MIC, 3 μg mL(-1). At this and higher concentrations, complete leakage after an initial lag time was observed. Concerted activity tests imply that this polymer acts independently of the detergent octyl glucoside (OG) for both vesicle leakage and activity against C. albicans spheroplasts. In addition, poly-NM was found to have negligible activity against zwitterionic vesicles and red blood cells. Our results provide a consistent, detailed picture of the mode of action of poly-NM: this polymer induces membrane leakage by electrostatic lipid clustering. In contrast, poly-MM:CO, a nylon-3 polymer comprised of both cationic and hydrophobic segments, seems to act by a different mechanism that involves membrane asymmetry stress. Vesicle leakage for this polymer is transient (limited to <100%) and graded, non-specific among zwitterionic and polar yeast lipid vesicles, additive with detergent action, and correlates poorly with biological activity. Based on these results, we conclude that comprehensive leakage experiments can provide a detailed description of the mode of action of membrane permeabilizing compounds. Without this thorough approach, it would have been logical to assume that the two nylon-3 polymers we examined act via similar mechanisms; it is surprising that their mechanisms are so distinct. Some, but not all mechanisms of vesicle permeabilization allow for antimicrobial activity.
Location of Gene for β Subunit of Human T-Cell Receptor at Band 7q35, a Region Prone to Rearrangements in T Cells (1985)

The T-cell receptor is formed by two chains, alpha and beta, for which specific clones were recently obtained. In this report the gene for the beta chain of the human T-cell receptor was located on the long arm of chromosome 7, band q35, by means of in situ hybridization. This chromosome region in T cells is unusually prone to develop breaks in vivo, perhaps reflecting instability generated by somatic rearrangement of T-cell receptor genes during normal differentiation in this cell lineage.
Compensation of shallow silicon donors by deep copper acceptors in gallium arsenide (1993)

Electrical compensation in n-type, silicon-doped, GaAs (GaAs:Si) has been achieved for several different silicon doping densities. The introduction of deep copper acceptors into GaAs:Si through a thermal diffusion process has produced semi-insulating GaAs:Si:Cu. The density of diffused copper is shown to be predicted, to a good approximation, by knowledge of both the annealing temperature at which compensation is observed, and the initial free-electron density. Also, a model based on Fermi–Dirac statistics has demonstrated the same qualitative behavior as the data.
Structural and spectroscopic studies of transition metal nitrite complexes. VI. Crystal structures and spectra of Hexakis(imidazole)nickel(II) dinitrate, trans -Tetrakis(2-methylimidazole)dinitritonickel(II) and cis -Tetrakis(2-methylimidazole)-(nitrito-O,O')nickel(II) nitrate-methanol (2/1) (1981)

The crystal structures and spectroscopic properties of the complexes cis -tetrakis(2-methy1imidazole)-(nitrito- O,O' )nickel(II) nitrate-methanol (2/1) and trans -tetrakis(2-methylimidazole)dinitritonickel(II) are reported. The nitrite group in the former compound chelates, giving a distorted octahedral ligand coordination geometry. The ligand stereochemistry in the second complex is also a distorted octahedron, with both anions coordinating as trans nitrito groups though with significantly different Ni-O bond lengths and the nickel(II) ion being raised out of the plane of the four imidazole ligand nitrogen atoms towards the closer nitrite group. The Ni-O bond directions also deviate substantially from the fourfold symmetry axis in this latter complex. These distortions apparently occur in order to minimize ligand-ligand repulsions, particularly those associated with the amine methyl substituents. The electronic spectra of both complexes show significant band splittings due to the departure of the ligand field from regular octahedral symmetry and these are discussed in terms of the relative field strengths of the imidazole and nitrito ligands. The structure of hexakis(imidazole)nickel(II) nitrate (redetermination) is also reported.
Sonographic diagnosis of pancreatic islet cell tumor: Value of intermittent harmonic imaging (2001)

We describe a case of nonfunctioning islet cell tumor of the pancreas diagnosed preoperatively by intermittent harmonic power Doppler imaging and digital subtraction gray-scale harmonic imaging and the use of the contrast agent SH U 508A (Levovist). Hypervascularity and tumor perfusion were clearly demonstrated with both harmonic imaging techniques in the early arterial phase. Sonographic findings were confirmed by other modalities and by histopathologic examination. © 2001 John Wiley & Sons, Inc. J Clin Ultrasound 29:411–416, 2001.
Design Patterns: Building Blocks for Illumination Systems (2022)

Illumination optics deals with the task of capturing light from a source and transforming it in a way that delivers what is desired at the target. Sometimes this transformation can be accomplished with a single optical element; at other times, a complex combination of several elements is required. Either way, it is very rare that something uniquely new is invented. Most of the time, we reuse, modify, and combine known solution approaches for the transformation (sub)tasks. We term these building blocks design patterns (a common notion in software engineering); and we think of them as an architect does when creating a building, by reusing, modifying, and combining elements such as foundations, walls, windows, and many more.
Interactions of eye and eyelid movements (2011)

Eyelid movements introduce a profound and transient modification in the positions of the eyes. This chapter describes the types of eye position perturbations and highlights the neural signatures within the oculomotor neuraxis that may mediate them. Such results imply that neural commands considered to encode a coordinated movement of the eyes and the head may, in fact, also integrate movements of the eyelid musculature as well as other skeletomotor effectors. This review also considers the use of blinks as a tool to evaluate the time-course of motor preparation of saccades and to probe whether a premotor signal is present during cognitive processes requiring executive control.
Online and Social Media Data As an Imperfect Continuous Panel Survey (2016)

There is a large body of research on utilizing online activity as a survey of political opinion to predict real world election outcomes. There is considerably less work, however, on using this data to understand topic-specific interest and opinion amongst the general population and specific demographic subgroups, as currently measured by relatively expensive surveys. Here we investigate this possibility by studying a full census of all Twitter activity during the 2012 election cycle along with the comprehensive search history of a large panel of Internet users during the same period, highlighting the challenges in interpreting online and social media activity as the results of a survey. As noted in existing work, the online population is a non-representative sample of the offline world (e.g., the U.S. voting population). We extend this work to show how demographic skew and user participation is non-stationary and difficult to predict over time. In addition, the nature of user contributions varies substantially around important events. Furthermore, we note subtle problems in mapping what people are sharing or consuming online to specific sentiment or opinion measures around a particular topic. We provide a framework, built around considering this data as an imperfect continuous panel survey, for addressing these issues so that meaningful insight about public interest and opinion can be reliably extracted from online and social media data.
Supplementary Table S1 from Molecular Drivers of the Non–T-cell-Inflamed Tumor Microenvironment in Urothelial Bladder Cancer (2023)

&lt;p&gt;Differentially expressed genes in non-T cell-inflamed vs. T cell-inflamed tumors&lt;/p&gt;
Combining fMRI and SNP data to investigate connections between brain function and genetics using parallel ICA (2007)

There is current interest in understanding genetic influences on both healthy and disordered brain function. We assessed brain function with functional magnetic resonance imaging (fMRI) data collected during an auditory oddball task--detecting an infrequent sound within a series of frequent sounds. Then, task-related imaging findings were utilized as potential intermediate phenotypes (endophenotypes) to investigate genomic factors derived from a single nucleotide polymorphism (SNP) array. Our target is the linkage of these genomic factors to normal/abnormal brain functionality. We explored parallel independent component analysis (paraICA) as a new method for analyzing multimodal data. The method was aimed to identify simultaneously independent components of each modality and the relationships between them. When 43 healthy controls and 20 schizophrenia patients, all Caucasian, were studied, we found a correlation of 0.38 between one fMRI component and one SNP component. This fMRI component consisted mainly of parietal lobe activations. The relevant SNP component was contributed to significantly by 10 SNPs located in genes, including those coding for the nicotinic alpha-7 cholinergic receptor, aromatic amino acid decarboxylase, disrupted in schizophrenia 1, among others. Both fMRI and SNP components showed significant differences in loading parameters between the schizophrenia and control groups (P = 0.0006 for the fMRI component; P = 0.001 for the SNP component). In summary, we constructed a framework to identify interactions between brain functional and genetic information; our findings provide a proof-of-concept that genomic SNP factors can be investigated by using endophenotypic imaging findings in a multivariate format.
Inversion‐recovery‐prepared dixon bSSFP: Initial clinical experience with a novel pulse sequence for renal MRA within a breathhold (2011)

We have demonstrated a promising non-CE MRA method for acquiring renal angiograms within a breathhold without any compromise in spatial resolution or coverage. ECG-gated NORISKS is able to acquire renal angiograms that are comparable to a routine clinical non-CE MRA method (Inhance IFIR, GE Healthcare), which requires approximately seven times the scan time of NORISKS.
Structure-guided inhibitor design for human FAAH by interspecies active site conversion (2008)

The integral membrane enzyme fatty acid amide hydrolase (FAAH) hydrolyzes the endocannabinoid anandamide and related amidated signaling lipids. Genetic or pharmacological inactivation of FAAH produces analgesic, anxiolytic, and antiinflammatory phenotypes but not the undesirable side effects of direct cannabinoid receptor agonists, indicating that FAAH may be a promising therapeutic target. Structure-based inhibitor design has, however, been hampered by difficulties in expressing the human FAAH enzyme. Here, we address this problem by interconverting the active sites of rat and human FAAH using site-directed mutagenesis. The resulting humanized rat (h/r) FAAH protein exhibits the inhibitor sensitivity profiles of human FAAH but maintains the high-expression yield of the rat enzyme. We report a 2.75-A crystal structure of h/rFAAH complexed with an inhibitor, N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carboxamide (PF-750), that shows strong preference for human FAAH. This structure offers compelling insights to explain the species selectivity of FAAH inhibitors, which should guide future drug design programs.
Mechanotransduction through Integrins (2004)

The goal of this project was to characterize the molecular mechanism by which cells recognize and respond to physical forces in their local environment. The project was based on the working hypothesis that cells sense mechanical stresses through cell surface integrin receptors and through their interconnections with the underlying cytoskeleton. Work completed and published in past funding period had provided direct support for this hypothesis. In particular, we demonstrated that application of mechanical stresses to activated integrin receptors (but not inactive integrins or other control transmembrane receptors) resulted in stress-dependent activation of the CAMP signaling pathway leading to gene transcription. We also showed that this form of mechanotransduction requires activation of heterotrimeric G proteins. In this grant, our specific aims included: 1) to characterize the signal processing capabilities of different integrins and other cell surface receptors, 2) to identify heterotrimeric G proteins that mediate CAMP signaling by stresses applied to integrins, 3) to identify molecules that mediate transmembrane mechanochemical coupling between integrins and G proteins, and 4) to use genome-wide gene expression profiling techniques to identify other genes and signaling pathways that are activated by mechanical forces transmitted over specific cell surface receptors. Elucidation of the mechanism by which cells sense mechanical stresses through integrins and translate them into a biochemical response should help us to understand the molecular basis of the cellular response to gravity as well as many other forms of mechanosensation and tissue regulation.
Zero-error Function Computation on a Directed Acyclic Network (2018)

We study the rate region of variable-length source-network codes that are used to compute a function of messages observed over a network. The particular network considered here is the simplest instance of a directed acyclic graph (DAG) that is not a tree. Existing work on zero-error function computation in DAG networks provides bounds on the computation capacity, which is a measure of the amount of communication required per edge in the worst case. This work focuses on the average case: an achievable rate tuple describes the expected amount of communication required on each edge, where the expectation is over the probability mass function of the source messages. We describe a systematic procedure to obtain outer bounds to the rate region for computing an arbitrary demand function at the terminal. Our bounding technique works by lower bounding the entropy of the descriptions observed by the terminal conditioned on the function value and by utilizing the Schur-concave property of the entropy function.
Appendix A (2013)

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