gebhart/patrepeval huggingface dataset:
Degradation Mechanisms of Biodegradable Poly(DL‐lactide‐co‐glycolide)1000 Diacrylate Network as Studied by Proton Solid‐State Flow NMR Relaxometry (2008)

Abstract Summary: Degradation mechanisms of biodegradable photo‐polymerised poly( DL ‐lactide‐ co ‐glycolide)1000 diacrylate {[( DL ‐LA/GA)DA]} matrices or films were studied by proton solid‐state NMR relaxometry. A flow NMR unit cell was developed for this purpose. The ( DL ‐LA/GA)DA‐network was degraded in PBS buffer solution of pH = 7.4. A real‐time proton NMR method provided information about the staged break down of the network during continuous circulation of the buffer solution through the NMR tube. The current study shows that degradation of the network proceeds in three stages: 1 ‐ extraction of a sol fraction that causes substantial immobilization of the material, 2 ‐ scissions of network chains producing network defects without formation of extractable products, and 3 – finally, chain scissions that cause formation of a sol fraction and complete degradation of the material. It was shown that the [( DL ‐LA/GA)DA‐network was composed of rigid and viscoelastic domains on all stages of degradation. This heterogeneity could be due to heterogeneous spatial distribution of network junctions in the initial network and/or nano‐scale phase separation of polyacrylate chains that form multifunctional network junctions and poly(lactide‐ co ‐glicolide) network chains. A combination of bulk and surface erosion both on nano‐ and macroscopic scales could explain the observed degradation mechanisms. It is shown that knowledge of weight loss upon hydrolytic degradation is not sufficient for understanding degradation mechanisms in the relation to functional properties of this type of hydrogels.
Biomolecular Sensing with Ultrafine Optical Fibers and Plasmonic Nanostructures (2009)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text D. J. Sirbuly, S. Baker, S. Zlatanovic, J. Steiner, and S. Esener, "Biomolecular Sensing with Ultrafine Optical Fibers and Plasmonic Nanostructures," in Frontiers in Optics 2009/Laser Science XXV/Fall 2009 OSA Optics & Photonics Technical Digest, OSA Technical Digest (CD) (Optica Publishing Group, 2009), paper FWR1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Supplementary Figure Legends from <i>EGFR</i> and <i>MET</i> Amplifications Determine Response to HER2 Inhibition in <i>ERBB2</i>-Amplified Esophagogastric Cancer (2023)

&lt;p&gt;Supplementary Figure Legends&lt;/p&gt;
Low-Cost Fiducial-based 6-Axis Force-Torque Sensor (2020)

Commercial six-axis force-torque sensors suffer from being some combination of expensive, fragile, and hard-touse. We propose a new fiducial-based design which addresses all three points. The sensor uses an inexpensive webcam and can be fabricated using a consumer-grade 3D printer. Open-source software is used to estimate the 3D pose of the fiducials on the sensor, which is then used to calculate the applied force-torque. A browser-based (installation free) interface demonstrates ease-of-use. The sensor is very light and can be dropped or thrown with little concern. We characterize our prototype in dynamic conditions under compound loading, finding a mean R <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> of over 0.99 for the F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> , F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">y</sub> , M <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> , and M <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">y</sub> axes, and over 0.87 and 0.90 for the F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">z</sub> and M <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">z</sub> axes respectively. The open source design files allow the sensor to be adapted for diverse applications ranging from robot fingers to human-computer interfaces, while the sdesign principle allows for quick changes with minimal technical expertise. This approach promises to bring six-axis force-torque sensing to new applications where the precision, cost, and fragility of traditional strain-gauge based sensors are not appropriate. The open-source sensor design can be viewed at http://sites.google.com/view/fiducialforcesensor.
Greater loss of axons in primary progressive multiple sclerosis plaques compared to secondary progressive disease (2009)

The pathological substrate of progressive disability in multiple sclerosis is hypothesized to be axonal loss. Differences in the demographic, pathological and radiological features of patients with primary progressive compared with secondary progressive multiple sclerosis raise the question as to whether they actually represent separate clinical entities. So far, large pathological studies comparing axonal damage between primary progressive and secondary progressive multiple sclerosis have not been reported. In this clinico-pathological study we examined the cervical spinal cord in patients with primary and secondary progressive multiple sclerosis. Human cervical spinal cord was derived at autopsy from 54 patients (17 primary progressive, 30 secondary progressive and 7 controls). Tissue was stained immunohistochemically and examined to determine: (i) the number of surviving corticospinal tract axons; (ii) the extent of grey and white matter demyelination; (iii) the degree of inflammation inside and outside of lesions; and (iv) the relationship between demyelination and axonal loss. Associated clinical data was used to calculate expanded disability status scale for each patient preceding death. Motor disability in the primary progressive and secondary progressive groups was similar preceding death. Secondary progressive multiple sclerosis patients showed considerably more extensive demyelination of both the white and grey matter of the cervical spinal cord. The total number of corticospinal axons was equally low in primary progressive and secondary progressive multiple sclerosis groups versus controls. The reduction of axonal density in demyelinated regions compared to normal appearing white matter was significantly more extensive in primary progressive versus secondary progressive patients (33% reduction versus 16% reduction, P < 0.001). These findings suggest axonal loss is the pathological substrate of progressive disability in both primary progressive and secondary progressive multiple sclerosis with a common plaque-centred mechanism. More extensive axonal loss within areas of demyelination in primary progressive multiple sclerosis could explain high levels of axonal loss observed in these patients despite low levels of demyelination.
Supplementary Data from DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-Based Antibody–Drug Conjugate Targeting B7-H3, Exerts Potent Antitumor Activities in Preclinical Models (2023)

Supplementary Data from DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-Based Antibody–Drug Conjugate Targeting B7-H3, Exerts Potent Antitumor Activities in Preclinical Models
Public-Key Authenticated Encryption with Keyword Search: A Generic Construction and Its Quantum-Resistant Instantiation (2021)

Abstract The industrial Internet of Things (IIoT) integrates sensors, instruments, equipment and industrial applications, enabling traditional industries to automate and intelligently process data. To reduce the cost and demand of required service equipment, IIoT relies on cloud computing to further process and store data. Public-key encryption with keyword search (PEKS) plays an important role, due to its search functionality, to ensure the privacy and confidentiality of the outsourced data and the maintenance of flexibility in the use of the data. Recently, Huang and Li proposed the ‘public-key authenticated encryption with keyword search’ (PAEKS) to avoid the insider keyword guessing attacks (IKGAs) in the previous PEKS schemes. However, all current PAEKS schemes are based on the discrete logarithm assumption and are therefore vulnerable to quantum attacks. In this study, we first introduce a generic PAEKS construction, with the assistance of a trusted authority, that enjoys the security against IKGA in the standard model, if all building blocks are secure under standard model. Based on the framework, we further propose a novel instantiation of quantum-resistant PAEKS that is based on NTRU assumption under random oracle. Compared with its state-of-the-art counterparts, the experiment result indicates that our instantiation is more efficient and secure.
Abstract 17729: Expression Profiles of Circulating MicroRNA in Heart Failure With Reduced and Preserved Ejection Fraction in Asia Population (2013)

The important roles of microRNAs (miRNAs) in cardiovascular development and cardiac response to acute and chronic injury are increasingly being recognized. MiRNAs play important roles in cardiac diseases. Circulating miRNA signatures may offer diagnostic and pathogenic information. These circulating profiles in Heart Failure with Reduced (HFREF) or Preserved (HFPEF) ejection fraction remain to be defined. We hypothesized that HFREF and HFPEF are associated with distinct circulating miRNA signatures that may offer insight into the underlying mechanisms distinguishing both phenotypes. MiRNA profiling was performed on plasma from 16 healthy controls, 18 HFREF and 13 HFPEF. MiRNAs levels were compared between healthy controls, HFREF, HFPEF and combined HF. The miRNAs that distinguished between HFREF and HFPEF were miR-103-2, -130b, -141, -143, -181c, -199a-5p, -200b, -223, -26b, -340 and -7-1 (p-values 0.001-0.049). Four such miRNAs were miR-130b, -143, -200b and -7-1 were highly differentially regulated in HFPEF as compared to control (p-values 0.001-0.03). The miRNAs that distinguished HFREF from control were let-7f, miR-103, -145, -193b and -339-5p (p-values 0.01-0.049). The miRNAs distinguished HF from control were let-7d, miR-126, -143, -181a, -30b, -30d, -345 and -376b (p-values 0.001-0.042). These miRNAs signatures with highly predicted target associated with neurohormone were selected for ongoing validation in a larger sample size study. MiR-143 with the predicted targets of natriuretic peptide B (BNP) and natriuretic peptide receptor C (NPR3) was found to be highly dysregulated in in-vitro model. Cardiomyocytes were subjected to hypoxic condition at 0.2 % of oxygen over 2 and 120 hours. MiR-143 expression was significantly regulated in correlation with NPR3 level. Ongoing functional assay will further decipher the biological function of miR-143. This study shows specific plasma miRNA signatures that could be valuable biomarkers to distinguish between HFREF and HFPEF and from control. This is the first study in Asia to undertake a comparison of miRNA profiles in patients of these two phenotypes. Further study in in-vitro model on miR-143 deciphers the plausible underlying mechanism that can lead to HF.
Topology optimization for the design of folding liquid crystal elastomer actuators (2015)

Aligned liquid crystal elastomers (LCEs) are capable of undergoing large reversible shape change in response to thermal stimuli and may act as actuators for many potential applications such as self-assembly and deployment of micro devices. Recent advances in LCE patterning tools have demonstrated sub-millimetre control of director orientation, enabling the preparation of materials with arbitrarily complex director fields. However, without design tools to connect the 2D director pattern with the activated 3D shape, LCE design relies on intuition and trial and error. Here we present a design methodology to generate reliable folding in monolithic LCEs designed with topology optimization. The distributions of order/disorder and director orientations are optimized so that the remotely actuated deformation closely matches a target deformation for origami folding. The optimal design exhibits a strategy to counteract the mechanical frustration that may lead to an undesirable deformation, such as anti-clastic bending. Multi-hinge networks were developed using insights from the optimal hinge designs and were demonstrated through the fabrication and reversible actuation of a self-folding box. Topology optimization provides an important step towards leveraging the opportunities afforded by LCE patterning into functional designs.
Vascular Accessibility of Endothelial Targeted Ferritin Nanoparticles (2015)

Targeting nanocarriers to the endothelium, using affinity ligands to cell adhesion molecules such as ICAM-1 and PECAM-1, holds promise to improve the pharmacotherapy of many disease conditions. This approach capitalizes on the observation that antibody-targeted carriers of 100 nm and above accumulate in the pulmonary vasculature more effectively than free antibodies. Targeting of prospective nanocarriers in the 10-50 nm range, however, has not been studied. To address this intriguing issue, we conjugated monoclonal antibodies (Ab) to ICAM-1 and PECAM-1 or their single chain antigen-binding fragments (scFv) to ferritin nanoparticles (FNPs, size 12 nm), thereby producing Ab/FNPs and scFv/FNPs. Targeted FNPs retained their typical symmetric core-shell structure with sizes of 20-25 nm and ∼4-5 Ab (or ∼7-9 scFv) per particle. Ab/FNPs and scFv/FNPs, but not control IgG/FNPs, bound specifically to cells expressing target molecules and accumulated in the lungs after intravenous injection, with pulmonary targeting an order of magnitude higher than free Ab. Most intriguing, the targeting of Ab/FNPs to ICAM-1, but not PECAM-1, surpassed that of larger Ab/carriers targeted by the same ligand. These results indicate that (i) FNPs may provide a platform for targeting endothelial adhesion molecules with carriers in the 20 nm size range, which has not been previously reported; and (ii) ICAM-1 and PECAM-1 (known to localize in different domains of endothelial plasmalemma) differ in their accessibility to circulating objects of this size, common for blood components and nanocarriers.
Thermodynamics of Aminoglycoside−rRNA Recognition:  The Binding of Neomycin-Class Aminoglycosides to the A Site of 16S rRNA (2002)

We use spectroscopic and calorimetric techniques to characterize the binding of the aminoglycoside antibiotics neomycin, paromomycin, and ribostamycin to a RNA oligonucleotide that models the A-site of Escherichia coli 16S rRNA. Our results reveal the following significant features: (i) Aminoglycoside binding enhances the thermal stability of the A-site RNA duplex, with the extent of this thermal enhancement decreasing with increasing pH and/or Na(+) concentration. (ii) The RNA binding enthalpies of the aminoglycosides become more exothermic (favorable) with increasing pH, an observation consistent with binding-linked protonation of one or more drug amino groups. (iii) Isothermal titration calorimetry (ITC) studies conducted as a function of buffer reveal that aminoglycoside binding to the host RNA is linked to the uptake of protons, with the number of linked protons being dependent on pH. Specifically, increasing the pH results in a corresponding increase in the number of linked protons. (iv) ITC studies conducted at 25 and 37 degrees C reveal that aminoglycoside-RNA complexation is associated with a negative heat capacity change (Delta C(p)), the magnitude of which becomes greater with increasing pH. (v) The observed RNA binding affinities of the aminoglycosides decrease with increasing pH and/or Na(+) concentration. In addition, the thermodynamic forces underlying these RNA binding affinities also change as a function of pH. Specifically, with increasing pH, the enthalpic contribution to the observed RNA binding affinity increases, while the corresponding entropic contribution to binding decreases. (vi) The affinities of the aminoglycosides for the host RNA follow the hierarchy neomycin > paromomycin > ribostamycin. The enhanced affinity of neomycin relative to either paromomycin or ribostamycin is primarily, if not entirely, enthalpic in origin. (vii) The salt dependencies of the RNA binding affinities of neomycin and paromomycin are consistent with at least three drug NH(3)(+) groups participating in electrostatic interactions with the host RNA. In the aggregate, our results reveal the impact of specific alterations in aminoglycoside structure on the thermodynamics of binding to an A-site model RNA oligonucleotide. Such systematic comparative studies are critical first steps toward establishing the thermodynamic database required for enhancing our understanding of the molecular forces that dictate and control aminoglycoside recognition of RNA.
Tradition and Future of the Korean Society of Plastic and Reconstructive Surgeons (2016)

Current day Hallyu (Korean wave) culture is rapidly spreading throughout Asia and the world, moving from the periphery of global culture towards the center. 'Plastic Surgery Hallyu' has joined K-pop, TV dramas, dancing, and food as one of the pillars of the Hallyu craze, and the Korean Society of Plastic and Reconstructive Surgeons (KSPRS) is showing the world its outstanding results in both surgery and research. In 2015, The Washington Post published a portrayal of plastic surgery in Korea, saying that "South Korea is the plastic surgery capital of the world"
609 Influence Head of Infant Child from Shaken Baby Syndrome (2011)

In Japan, accidental injury tops the list of the cause of child (1 to 19-year-old) death. This has continued since 1960. We pay attention about "Shaking baby syndrome" and influence the brain in the head that cannot be judged from the face. This is a syndrome to occur by abuse mainly. Currently, an intentional injury act such as this abuse is problem. In abuses, it is thought that the head injury of infant is the highest risk of death. In this head injury, there is not a clear standard for judgment that the head injury of infants is caused by abuse or an unexpected accident. So, to establish the standard, development of the technique that can estimate an injury process by objective information such as injury information and the spot information is demanded. I think it needs to understand the injury by abuse to discriminate from unexpected accident. I understand the injury by experiment. I use the child dummy doll for six months in experiment. I conduct two kinds of shake experiments by person and the vibration exciter. I change a parameter of the vibration such as acceleration, frequency, amplitude, phase difference using the vibration exciter. Therefore, the influence that the vibration exerts on the infant head was verified. As the result of experiments, I supposed high-risk frequency in shaking events.
What are the options for treating infections by persister‐forming pathogens? (2022)

Since biofilms clearly are not accumulating, in this opinion\npiece we hypothesize that the biofilms are used primarily\nas nutrients; hence, the biofilm matrix does not\naccumulate in the environment because it provides the\ncarbon, nitrogen, and phosphate building blocks for\nhungry microorganisms. Given that there are little data\nto support this hypothesis at present, we propose four\nscenarios for biofilm matrix recycling.
Experimental verification of frequency effects in tilting pad journal bearing dynamic coefficients (2021)

In this paper, vibrational frequency effect in dynamic coefficients of tilting pad journal bearing is verified experimentally. Tilting pad journal bearings (TPJB) is applied in various turbomachinery. Accurate evaluation of the bearing characteristics of TPJB is very important to ensure reliability of rotating machinery. To evaluate the stability of such rotating machinery for sub-synchronous vibration accurately, examination of damped vibrational frequency effects in dynamic coefficients of TPJB under various bearing load condition is necessary. In this study, excitation test with test rig of 4pad TPJB with two types of preload or pad offset ratio is carried out in various load condition. Especially, the test condition where the influence of fluid inertia is small is focused. Frequency effect in dynamic coefficients of TPJB is verified experimentally under the test condition. And, thermo-elastic-hydrodynamic-lubrication (TEHL) analysis is carried out. By comparing analytical results to experimental results, good agreement with experimental result and TEHL analytical result is confirmed. In addition, the influence of bearing load, load direction, pre-load or pad offset ratio on frequency effect is confirmed experimentally and analytically. The results that the frequency effect is larger as bearing load is lower (Sommerfeld number is larger), and the influence of pre-load of bearing on frequency effect is small and that of pad offset ratio (pivot position) is large is obtained.
Data from Phase I Study of Single-Agent Utomilumab (PF-05082566), a 4-1BB/CD137 Agonist, in Patients with Advanced Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Utomilumab (PF-05082566) is an agonistic mAb that engages the immune costimulatory molecule 4-1BB/CD137. In this first-in-human, phase I, open-label, multicenter, multiple-dose study (NCT01307267) we evaluated safety, tolerability, pharmacokinetics, preliminary clinical activity, and pharmacodynamics of single-agent utomilumab in patients with advanced malignancies.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Dose escalation was based on a standard 3+3 design for doses of utomilumab from 0.006 to 0.3 mg/kg every 4 weeks and a time-to-event continual reassessment method for utomilumab 0.6 to 10 mg/kg every 4 weeks. The primary study endpoint was dose-limiting toxicity (DLT) in the first two cycles.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Utomilumab demonstrated a well-tolerated safety profile (&lt;i&gt;N&lt;/i&gt; = 55). None of the patients experienced a DLT at the dose levels evaluated. The most common treatment-related adverse events were fatigue, pyrexia, decreased appetite, dizziness, and rash (&lt;10% of patients). Only one (1.8%) patient experienced a grade 3–4 treatment-related adverse event (fatigue), and no clinically relevant elevations in transaminases were noted. Utomilumab demonstrated linear pharmacokinetics at doses ranging from 0.006 to 10 mg/kg, with similar safety and pharmacokinetics in anti-drug antibody (ADA)-negative and ADA-positive patients. The overall objective response rate was 3.8% (95% CI, 0.5%–13.0%) in patients with solid tumors and 13.3% in patients with Merkel cell carcinoma, including a complete response and a partial response. Circulating biomarkers support 4-1BB/CD137 engagement by utomilumab and suggest that circulating lymphocyte levels may influence probability of clinical benefit.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; The favorable safety profile and preliminary antitumor activity demonstrated by utomilumab warrant further evaluation in patients with advanced malignancies. &lt;i&gt;Clin Cancer Res; 24(8); 1816–23. ©2018 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Isolated Pontine Progressive Multifocal Leukoencephalopathy: Unusual Magnetic Resonance Imaging Features (2002)

Progressive multifocal leukoencephalopathy (PML) is an uncommon opportunistic infection that causes focal or multifocal demyelination predominantly in the subcortical white matter. The authors describe the clinical and radiographic features in 2 unusual cases of PML that were initially isolated to the pons. One patient presented clinically with only an isolated sixth cranial nerve palsy.
Energy-Efficient Software-Defined Radio Solutions For Mimo-Based Broadband Communication (2007)

Publication in the conference proceedings of EUSIPCO, Poznan, Poland, 2007