gebhart/patrepeval huggingface dataset:
A phase I/IIa clinical trial investigating the therapeutic cancer vaccine UV1 in combination with ipilimumab in patients with malignant melanoma: Four-year survival update. (2020)

62 Background: Combining checkpoint blockade with a cancer vaccine may induce broader immune responses, leading to better clinical outcomes. UV1 targets the enzyme telomerase (hTERT) which is expressed in almost all cancer types and is essential for the immortality of cancer cells and a hallmark of cancer. UV1 consists of three synthetic long peptides and vaccination induces Th1 responses in most patients irrespective of HLA type. This trial explores the synergistic effect of CTLA-4 blockade and hTERT vaccination, allowing unchecked expansion of hTERT-specific T cell clones. Increased number of tumor-specific T cells is associated with a favorable clinical outcome in patients with metastatic melanoma. We investigated the safety, immunological and clinical responses of UV1 vaccine and ipilimumab in this group of patients. Methods: In a phase I/IIa, single-center trial (NCT02275416) patients with metastatic melanoma received treatment with UV1 (300 µg) + GM-CSF (75 µg) as an adjuvant, combined with ipilimumab (3 mg/kg). Safety was assessed according to CTCAE v. 4.0, and tumor responses according to RECIST v.1.1. Immune responses against UV1 peptides were monitored in peripheral mononuclear blood cells by using 3 H-thymidine proliferation and IFN-γ ELISPOT assays. Tumor mutational burden (TMB) estimations were based on whole-exome sequencing. Results: 12 patients were treated from Feb to Nov 2015. Treatment was generally well tolerated. Adverse events mainly included injection site reactions and diarrhea. Immune responses occurred very early and 10/11 evaluable patients showed an immune response. Three patients obtained a partial response, and one patient a complete response. 3-year overall survival (OS) was 67%. 4-year survival outcome will be presented along with baseline characteristics and TMB estimations. Conclusions: Combining UV1 and ipilimumab is safe and induces clinical responses in melanoma. The high proportion of immunological responders and early induction of detectable immune responses suggest synergism. OS compares favorably to historical controls. Clinical trial information: NCT02275416.
Degradation behaviors and mechanisms of MoS2 crystals relevant to bioabsorbable electronics (2018)

Monolayer molybdenum disulfide (MoS2) exhibits unique semiconducting and bioresorption properties, giving this material enormous potential for electronic/biomedical applications, such as bioabsorbable electronics. In this regard, understanding the degradation performance of monolayer MoS2 in biofluids allows modulation of the properties and lifetime of related bioabsorbable devices and systems. Herein, the degradation behaviors and mechanisms of monolayer MoS2 crystals with different misorientation angles are explored. High-angle grain boundaries (HAGBs) biodegrade faster than low-angle grain boundaries (LAGBs), exhibiting degraded edges with wedge and zigzag shapes, respectively. Triangular pits that formed in the degraded grains have orientations opposite to those of the parent crystals, and these pits grow into larger pits laterally. These behaviors indicate that the degradation is induced and propagated based on intrinsic defects, such as grain boundaries and point defects, because of their high chemical reactivity due to lattice breakage and the formation of dangling bonds. High densities of dislocations and point defects lead to high chemical reactivity and faster degradation. The structural cause of MoS2 degradation is studied, and a feasible approach to study changes in the properties and lifetime of MoS2 by controlling the defect type and density is presented. The results can thus be used to promote the widespread use of two-dimensional materials in bioabsorption applications. The mechanism by which two-dimensional electronic materials decompose in an environment similar to that inside the human body has been identified by researchers in South Korea. Biodegradable, or transient, electronic devices disappear when no longer needed. In biomedical applications, for example, a transient sensor in the body degrades or dissolves, eliminating the need for surgery to remove it. Jong-Hyun Ahn from Yonsei University in Seoul and co-workers investigated the degradation of crystals of the two-dimensional semiconductor molybdenum disulfide (MoS2), each having the triangular shape. They showed that the rate of decomposition is dependent on the angle of misalignment between the two crystals: crystals with a larger misalignment biodegrade faster than those more closely aligned. This behavior indicates that intrinsic defects in the atomic structure of the material are the cause of the degradation. We present the degradation behaviors and mechanisms of CVD-grown monolayer MoS2 crystals relevant to bioabsorbable electronics, triggered and extended based on the intrinsic defects such as grain boundaries and point defects for their high chemical reactivity caused by broken lattice and dangling bonds. Higher misorientation angle leads to higher degradation speed. This work paves the way for lifetime modulation and bioabsorbable device application by using 2D materials.
A Study on High Efficiency Wing-vane Compressor - Part.3: Experimental Evaluation of the Prototype - (2016)

Low global warming refrigerants such as HFO (hydro fluoro olefin) -1234yf areÂ attracted as an alternative working fluid in air-conditioning and cooling systems to address global warming. However, it used to require larger compressor size due to the lower fluid density compared with conventional refrigerants such as R410A. Thus, a new wing-vane compressor which has no contraction between the vane and the cylinder is developed to prevent increase in the size without performance degradation. The structure of the wing-vane compressor is different from the conventional vane compressor. Therefore, a prototype of the wing-vane compressor was operated using R134a refrigerant to simulate HFO-1234yfÂ refrigerant. The results are as follows: (1) The steady operation is observed in the general operating condition. (2) The steady mechanism of vane is clarified by both experiment and simulation. (3) A simple lubrication structure is achieved by supplying the oil to the friction surface through the grooves with the partial arc guide bearings.
Did the Lenke Classification Change Scoliosis Treatment? (2011)

The introduction of this system has led to a reduction in the variation of treatment approaches; however, our data suggest that 6% to 29% of the time, depending on the curve pattern, there are other aspects of the clinical and radiographic deformity that suggest deviation from the recommendations of the classification system. The outcome of adherence to this system remains yet to be evaluated.
Data Mining for ISHM of Liquid Rocket Propulsion Status Update (2006)

This document consists of presentation slides that review the current status of data mining to support the work with the Integrated Systems Health Management (ISHM) for the systems associated with Liquid Rocket Propulsion. The aim of this project is to have test stand data from Rocketdyne to design algorithms that will aid in the early detection of impending failures during operation. These methods will be extended and improved for future platforms (i.e., CEV/CLV).
Measurements of the suppression and correlations of dijets in Xe+Xe collisions at sNN=5.44 TeV (2023)

Measurements of the suppression and correlations of dijets is performed using $3\phantom{\rule{4pt}{0ex}}\textmu{}{\mathrm{b}}^{\ensuremath{-}1}$ of Xe+Xe data at $\sqrt{{s}_{NN}}=5.44$ TeV collected with the ATLAS detector at the CERN Large Hadron Collider. Dijets with jets reconstructed using the $R=0.4$ anti-${k}_{t}$ algorithm are measured differentially in jet ${p}_{\text{T}}$ over the range of 32 to 398 GeV and the centrality of the collisions. Significant dijet momentum imbalance is found in the most central Xe+Xe collisions, which decreases in more peripheral collisions. Results from the measurement of per-pair normalized and absolutely normalized dijet ${p}_{\text{T}}$ balance are compared with previous $\mathrm{Pb}+\mathrm{Pb}$ measurements at $\sqrt{{s}_{NN}}=5.02$ TeV. The differences between the dijet suppression in Xe+Xe and $\mathrm{Pb}+\mathrm{Pb}$ are further quantified by the ratio of pair nuclear-modification factors. The results are found to be consistent with those measured in $\mathrm{Pb}+\mathrm{Pb}$ data when compared in classes of the same event activity and when taking into account the difference between the center-of-mass energies of the initial parton scattering process in Xe+Xe and $\mathrm{Pb}+\mathrm{Pb}$ collisions. These results should provide input for a better understanding of the role of energy density, system size, path length, and fluctuations in the parton energy loss.
Ladderlike Ferromagnetic Spin Coupling Network on a π-Conjugated Pendant Polyradical (2003)

A poly(9,10-anthryleneethynylene)-based polyradical with two pendant stable phenoxyls in one anthracene skeleton was newly synthesized via polymerization of the corresponding bromoethynylanthracene monomer using a Pd(0) catalyst. The average molecular weight of the polymer reached M(n) = 5 x 10(3) and was soluble in common organic solvents. The polyradical was prepared from the corresponding hydroxyl precursor polymer and was appropriately stable at room temperature. The ESR spectrum of the corresponding monomeric radical suggested an effectively delocalized spin density distribution on the backbone anthracene. The magnetization and the static magnetic susceptibility of the polyradical were measured using a SQUID magnetometer. The large average spin quantum number (S = (5)/(2)) of the polyradical indicated that the ferromagnetic spin coupling network of the polyradical had spread throughout the pi-conjugated chain and that it was considerably insensitive to spin defects.
Versatility of p-sulfonatocalix[5]arene in building up multicomponent bilayers (2008)

The ability of pyridine N-oxide molecules to form host–guest complexes with p-sulfonatocalix-[5]arene was probed and resulted in the formation of europium complexes incorporating 2- or 4-picoline N-oxide, and 4,4′-dipyridine N,N′-dioxide. Relative to lanthanide complexes of p-sulfonatocalix[5]arene incorporating pyridine N-oxide, the presence of a methyl group on the aromatic ring for the picoline N-oxides, or a larger dipyridine dioxide guest dramatically alters the self-assembly, resulting in the formation of three new supramolecular motifs for the calixarene.
Glucose accumulation by rat small-intestinal mucosa after depletion of intracellular adenosine triphosphate (1972)

Research Article| June 01 1972 Glucose accumulation by rat small-intestinal mucosa after depletion of intracellular adenosine triphosphate H J Leese; H J Leese 1Department of Biology, University of York, Heslington, York YO1 5DD, U.K. Search for other works by this author on: This Site PubMed Google Scholar J R Bronk J R Bronk 1Department of Biology, University of York, Heslington, York YO1 5DD, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1972) 128 (2): 455–457. https://doi.org/10.1042/bj1280455 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share MailTo Twitter LinkedIn Cite Icon Cite Get Permissions Citation H J Leese, J R Bronk; Glucose accumulation by rat small-intestinal mucosa after depletion of intracellular adenosine triphosphate. Biochem J 1 June 1972; 128 (2): 455–457. doi: https://doi.org/10.1042/bj1280455 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1972 London: The Biochemical Society1972 Article PDF first page preview Close Modal You do not currently have access to this content.
The Effect of Swab Sample Choice on the Detection of Avian Influenza in Apparently Healthy Wild Ducks (2012)

Historically, avian influenza viruses have been isolated from cloacal swab specimens, but recent data suggest that the highly pathogenic avian influenza (HPAI) H5N1 virus can be better detected from respiratory tract specimens. To better understand how swab sample type affects the detection ability of low pathogenic avian influenza (LPAI) viruses we collected and tested four swab types: oropharyngeal swabs (OS), cloacal swabs (CS), the two swab types combined in the laboratory (LCS), and the two swab types combined in the field (FCS). A total of 1968 wild waterfowl were sampled by each of these four methods and tested for avian influenza virus using matrix gene reverse-transcription (RT)-PCR. The highest detection rate occurred with the FCS (4.3%) followed by the CS (4.0%). Although this difference did not achieve traditional statistical significance, Bayesian analysis indicated that FCS was superior to CS with an 82% probability. The detection rates for both the LCS (2.4%) and the OS (0.4%) were significantly different from the FCS. In addition, every swab type that was matrix RT-PCR positive was also tested for recovery of viable influenza virus. This protocol reduced the detection rate, but the ordering of swab types remained the same: 1.73% FCS, 1.42% CS, 0.81% LCS, and 0% OS. Our data suggest that the FCS performed at least as well as any other swab type for detecting LPAI viruses in the wild ducks tested. When considering recent studies showing that HPAI H5N1 can be better detected in the respiratory tract, the FCS is the most appropriate sample to collect for HPAI H5N1 surveillance while not compromising LPAI studies.
Facilitating Change Implementation for Continuous ML-Safety Assurance (2022)

We propose a method for deploying a safety-critical machine-learning component into continuously evolving environments where an increased degree of automation in the engineering process is desired. We associate semantic tags with the safety case argumentation and turn each piece of evidence into a quantitative metric or a logic formula. With proper tool support, the impact can be characterized by a query over the safety argumentation tree to highlight evidence turning invalid. The concept is exemplified using a vision-based emergency braking system of an autonomous guided vehicle for factory automation.
Directed incremental symbolic execution (2011)

The last few years have seen a resurgence of interest in the use of symbolic execution -- a program analysis technique developed more than three decades ago to analyze program execution paths. Scaling symbolic execution and other path-sensitive analysis techniques to large systems remains challenging despite recent algorithmic and technological advances. An alternative to solving the problem of scalability is to reduce the scope of the analysis. One approach that is widely studied in the context of regression analysis is to analyze the differences between two related program versions. While such an approach is intuitive in theory, finding efficient and precise ways to identify program differences, and characterize their effects on how the program executes has proved challenging in practice. In this paper, we present Directed Incremental Symbolic Execution (DiSE), a novel technique for detecting and characterizing the effects of program changes. The novelty of DiSE is to combine the efficiencies of static analysis techniques to compute program difference information with the precision of symbolic execution to explore program execution paths and generate path conditions affected by the differences. DiSE is a complementary technique to other reduction or bounding techniques developed to improve symbolic execution. Furthermore, DiSE does not require analysis results to be carried forward as the software evolves -- only the source code for two related program versions is required. A case-study of our implementation of DiSE illustrates its effectiveness at detecting and characterizing the effects of program changes.
Structured multimaterial filaments for 3D printing of optoelectronics (2019)

Simultaneous 3D printing of disparate materials; metals, polymers and semiconductors with device quality interfaces and at high resolution remains challenging. Moreover, the precise placement of discrete and continuous domains to enable both device performance and electrical connectivity poses barriers to current high-speed 3D-printing approaches. Here, we report filaments with disparate materials arranged in elaborate microstructures, combined with an external adhesion promoter, to enable a wide range of topological outcomes and device-quality interfaces in 3D printed media. Filaments, structured towards light-detection, are printed into fully-connected 3D serpentine and spherical sensors capable of spatially resolving light at micron resolution across its entire centimeter-scale surface. 0-dimensional metallic microspheres generate light-emitting filaments that are printed into hierarchical 3D objects dotted with electroluminescent pixels at high device resolution of 55 µm not restricted by surface tension effects. Structured multimaterial filaments provides a path towards custom three-dimensional functional devices not realizable by existing approaches.
High Temperature Power Electronics Packaging (2013)

The lack of robust and reliable packaging methods are considered to be one of the main challenges for the next generation of high temperature electronics (&gt;200 °C). Power electronics are especially difficult to operate in this environment. This project investigated packaging technologies suitable for a high temperature power module for operation up to 250 °C. The key technologies investigated were: • A novel type ceramic substrate active metal brazed (AMB) silicon nitride (Si3N4) showed no signs of degradation. • A state-of-the-art Au-Sn solid-liquid interdiffusion (SLID) die attach was developed. • Silicon carbide reinforced aluminium (AlSiC) with cold sprayed Cu was used as a base plate. • Different thermal interface materials were investigated. • Finally, a power module concept was developed. It was based on silicon carbide (SiC) bipolar transistors (BJT). The main conclusion drawn from this project is that reliable packaging technologies for 200 °C and beyond seem possible. Suitable packaging technologies are emerging but commercially available electronic components compatible with this temperature range and these novel technologies are still very sparse. Oppdragsgiver: Norwegian research council
Design approach to electroelastic composites (2023)

This paper presents mechanics based tools for the design of multifunctional polymer composite materials. The class of composite discussed consist of a low permittivity matrix material (typically polymer) with ferroelectric inclusions (piezoelectric/ferroelectric particles, rods, platelets) dispersed throughout. The high permittivity of the inclusions causes the electric field to concentrate in the matrix, which makes it challenging to get the electric field into the inclusions. Elasticity (biharmonic Laplace’s equation) and electrostatics (harmonic Laplace’s equation), provide closed form solutions for single inclusion geometries, providing the electric field distribution in the inclusion and in the matrix. These solutions are used to validate finite element models used to address interactions between inclusions. This discussion addresses 2-D dielectric circular inclusions embedded in a linear polymer matrix. The approach is readily extended to other inclusion geometries such as ellipse, sphere, and ellipsoid (plates and rods).
LISA: Increasing Internal Connectivity in DRAM for Fast Data Movement\n and Low Latency (2018)

This paper summarizes the idea of Low-Cost Interlinked Subarrays (LISA),\nwhich was published in HPCA 2016, and examines the work's significance and\nfuture potential. Contemporary systems perform bulk data movement movement\ninefficiently, by transferring data from DRAM to the processor, and then back\nto DRAM, across a narrow off-chip channel. The use of this narrow channel\nresults in high latency and energy consumption. Prior work proposes to avoid\nthese high costs by exploiting the existing wide internal DRAM bandwidth for\nbulk data movement, but the limited connectivity of wires within DRAM allows\nfast data movement within only a single DRAM subarray. Each subarray is only a\nfew megabytes in size, greatly restricting the range over which fast bulk data\nmovement can happen within DRAM.\n Our HPCA 2016 paper proposes a new DRAM substrate, Low-Cost Inter-Linked\nSubarrays (LISA), whose goal is to enable fast and efficient data movement\nacross a large range of memory at low cost. LISA adds low-cost connections\nbetween adjacent subarrays. By using these connections to interconnect the\nexisting internal wires (bitlines) of adjacent subarrays, LISA enables\nwide-bandwidth data transfer across multiple subarrays with little (only 0.8%)\nDRAM area overhead. As a DRAM substrate, LISA is versatile, enabling a variety\nof new applications. We describe and evaluate three such applications in\ndetail: (1) fast inter-subarray bulk data copy, (2) in-DRAM caching using a\nDRAM architecture whose rows have heterogeneous access latencies, and (3)\naccelerated bitline precharging by linking multiple precharge units together.\nOur extensive evaluations show that each of LISA's three applications\nsignificantly improves performance and memory energy efficiency on a variety of\nworkloads and system configurations.\n
The influence of turn-off dead time on the reverse-recovery behaviour of synchronous rectifiers in automotive DC/DC-converters (2009)

The current commutation from the channel into the body diode of a MOSFET synchronous rectifier as well as the relation of the PWM turn-off dead time and its reverse-recovery behaviour were simulated and investigated experimentally. Both, reverse-recovery charge and current can be reduced significantly by shortening the dead time to few 10 ns. It leads to an overall converter loss reduction of several percent. The improvement of the reverse-recovery behaviour is based on the turn-on dynamics of the diode. In the considered case it takes several 10 ns to enhance plasma in the n–-region of the body diode. Therefore, turning off of the synchronous rectifier before the plasma has reached a steady-state will lead to a lower reverse-recovery charge.
Fast Ferroelectric Liquid-Crystal Electrooptics (1995)

Present and future information technology requires ever faster data transmission rates, but conventional circuitry has serious limitations. In his Perspective, Walba describes a new generation of electrooptical devices based on liquid crystals. These ‘spatial light modulators’ can be integrated with silicon circuits to offer compact, ultrafast optical processing of data.
Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis (2023)

Recent advances on the development of bumped kinase inhibitors for treatment of cryptosporidiosis have focused on the 5-aminopyrazole-4-carboxamide scaffold, due to analogs that have less hERG inhibition, superior efficacy, and strong in vitro safety profiles. Three compounds, BKI-1770, -1841, and -1708, showed strong efficacy in C. parvum infected mice.