gebhart/patrepeval huggingface dataset:
Effects of Perinatal Hypoxia on Serum Unbound Free Fatty Acids and Lung Inflammatory Mediators (2001)

Cellular injury during tissue hypoxia is due, in part, to reactive intermediates released by activated leukocytes. We found that the inflammatory mediators tumor necrosis factor (TNF)-alpha, IL-6, and IL-1beta are elevated in situ in lung macrophages on day 14 following exposure of rats to intermittent or chronic hypoxia from birth. Because inflammatory mediators can increase lipolysis in adipocytes, we also measured serum unbound free fatty acids (FFAu)--the biologically active compartment of FFA--in rat pups exposed to intermittent or chronic hypoxia. FFAu values were markedly elevated during the first 2 days of life in all rats, displaying an approximately 3-fold decrease from day 2 to day 3. Exposure to chronic hypoxia significantly increased FFAu levels measured on day 13. Since elevated serum FFAu are known to suppress leukocyte activation, we speculate that increased FFAu levels represent a mechanism for attenuating inflammation and tissue injury following sublethal hypoxia in the perinatal period, either physiologically in the immediate newborn period, or as a late response to ongoing hypoxic insult.
Data from MAGE-A, mMage-b, and MAGE-C Proteins Form Complexes with KAP1 and Suppress p53-Dependent Apoptosis in MAGE-Positive Cell Lines (2023)

&lt;div&gt;Abstract&lt;p&gt;The MAGE-A, MAGE-B, and MAGE-C protein families comprise the class-I MAGE/cancer testes antigens, a group of highly homologous proteins whose expression is suppressed in all normal tissues except developing sperm. Aberrant expression of class I MAGE proteins occurs in melanomas and many other malignancies, and MAGE proteins have long been recognized as tumor-specific targets; however, their functions have largely been unknown. Here, we show that suppression of class I MAGE proteins induces apoptosis in the Hs-294T, A375, and S91 MAGE-positive melanoma cell lines and that members of all three families of MAGE class I proteins form complexes with KAP1, a scaffolding protein that is known as a corepressor of p53 expression and function. In addition to inducing apoptosis, MAGE suppression decreases KAP1 complexing with p53, increases immunoreactive and acetylated p53, and activates a p53 responsive reporter gene. Suppression of class I MAGE proteins also induces apoptosis in MAGE-A–positive, p53&lt;sup&gt;wt/wt&lt;/sup&gt; parental HCT 116 colon cancer cells but not in a MAGE-A–positive HCT 116 p53&lt;sup&gt;−/−&lt;/sup&gt; variant, indicating that MAGE suppression of apoptosis requires p53. Finally, treatment with MAGE-specific small interfering RNA suppresses S91 melanoma growth &lt;i&gt;in vivo&lt;/i&gt;, in syngenic DBA2 mice. Thus, class I MAGE protein expression may suppress apoptosis by suppressing p53 and may actively contribute to the development of malignancies and by promoting tumor survival. Because the expression of class I MAGE proteins is limited in normal tissues, inhibition of MAGE antigen expression or function represents a novel and specific treatment for melanoma and diverse malignancies. [Cancer Res 2007;67(20):9954–62]&lt;/p&gt;&lt;/div&gt;
Thermodynamics of DNA Triplex Formation in Oligomers with and without Cytosine Bases: Influence of Buffer Species, pH, and Sequence (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermodynamics of DNA Triplex Formation in Oligomers with and without Cytosine Bases: Influence of Buffer Species, pH, and SequenceW. David Wilson, Harry P. Hopkins, Shaikh Mizan, David D. Hamilton, and Gerald ZonCite this: J. Am. Chem. Soc. 1994, 116, 8, 3607–3608Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April 1994https://pubs.acs.org/doi/10.1021/ja00087a060https://doi.org/10.1021/ja00087a060research-articleACS PublicationsRequest reuse permissionsArticle Views319Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Copper-Based Intermetallic Electride Catalyst for Chemoselective Hydrogenation Reactions (2017)

The development of transition metal intermetallic compounds, in which active sites are incorporated in lattice frameworks, has great potential for modulating the local structure and the electronic properties of active sites, and enhancing the catalytic activity and stability. Here we report that a new copper-based intermetallic electride catalyst, LaCu<sub>0.67</sub>Si<sub>1.33</sub>, in which Cu sites activated by anionic electrons with low work function are atomically dispersed in the lattice framework and affords selective hydrogenation of nitroarenes with above 40-times higher turnover frequencies (TOFs up to 5084 h<sup>-1</sup>) than well-studied metal-loaded catalysts. Kinetic analysis utilizing isotope effect reveals that the cleavage of the H-H bond is the rate-determining step. Surprisingly, the high carrier density and low work function (LWF) properties of LaCu<sub>0.67</sub>Si<sub>1.33</sub> enable the activation of hydrogen molecules with extreme low activation energy (E<sub>a</sub> = 14.8 kJ·mol<sup>-1</sup>). Furthermore, preferential adsorption of nitroarenes via a nitro group is achieved by high oxygen affinity of LaCu<sub>0.67</sub>Si<sub>1.33</sub> surface, resulting in high chemoselectivity. The present efficient catalyst can further trigger the hydrogenation of other oxygen-containing functional groups such as aldehydes and ketones with high activities. These findings demonstrate that the transition metals incorporated in the specific lattice site function as catalytically active centers and surpass the conventional metal-loaded catalysts in activity and stability.
Ultra-high efficiency light-emitting-diode arrays (1993)

An approach to increasing the escape probability for light-emitting diodes (LEDs) is proposed which involves the angular randomization by elastic scattering of the photons from a textured semiconductor surface. The approach has two components: (i) separation of thin-film heterojunctions from the growth substrate using the epitaxial liftoff (ELO) technique, and (ii) nanotexturing of the thin-film semiconductor interface by natural lithography. The LED structure is a conventional n/sup +/-AlGaAs/p-GaAs/p/sup +/-AlGaAs double heterostructure, grown over a 0.05 mu m thick AlAs release layer by organometallic chemical vapor deposition. The light versus current characteristics of the LEDs have been measured and modeled. A 9% external quantum efficiency from the untextured LED array was observed, transforming into a 30% external quantum efficiency following the surface texturing treatment. It is concluded that, by employing the principle of phase-space-filling in an improved device geometry, 56% efficient LED arrays can be expected.
The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations (2004)

This review addresses many of the chemical aspects of nitrosative stress mediated by N2O3. From a cellular perspective, N2O3 and the resulting reactive nitrogen oxide species target specific motifs such as thiols, lysine active sites, and zinc fingers and is dependant upon both the rates of production as well as consumption of NO and must be taken into account in order to access the nitrosative environment. Since production and consumption are integral parts of N2O3 generation, we predict that nitrosative stress occurs under specific conditions, such as chronic inflammation. In contrast to conditions of stress, nitrosative chemistry may also provide cellular protection through the regulation of critical signaling pathways. Therefore, a careful evaluation of the chemistry of nitrosation based upon specific experimental conditions may provide a better understanding of how the subtle balance between oxidative and nitrosative stress may be involved in the etiology and control of various disease processes.
Hesperetine-7-glucose is more effective than hesperidine for improving bone metaholism in the adult rat (2006)

National audience
Real-Time Frequency-Agile $\mathrm{Circuit}$ Reconfiguration for S-Band Radar Using a High-Power Tunable Resonant Cavity Matching Network (2018)

In the dynamic spectrum access paradigm, operating frequency and bandwidth are assigned in real time. Presently the S-band radar allocation is highly coveted for spectrum sharing with wireless communications. To share the band with wireless systems, next-generation radar transmitters must be able to reconfigure in both frequency and spectrum usage in real time. We demonstrate S-band reconfigurability of a high-power tunable evanescent-mode cavity matching network capable of 90 w of RF power handling. The system can switch between different operating frequencies, optimizing its power-added efficiency (PAE) while meeting simultaneous adjacent-channel power ratio (ACPR) constraints. This reconfiguration capability provides a useful building block for dynamic coexistence of a radar transmitter with other wireless systems in the S band.
Nonlinear photon-stimulated desorption from an oxidized tungsten surface (1998)

The results of a study of the laser Photon Stimulated Desorption (PSD) from an oxidized tungsten surface using 248 nm light are reported. The tungsten oxide system was chosen as a prototype for stimulated desorption resulting from the laser interaction with an oxide covered metal surface. The desorption yield, laser fluence dependence, and behavior of tungsten, tungsten oxide and other desorbed cations (including alkali atoms) have been used to probe aspects of the energetics under different conditions of oxygen dosage and laser exposure history. It is interesting to compare the nonlinear laser PSD results with the Electron Stimulated Desorption results which have appeared in the literature.
Structural Insights into Active Catalyst Structures and Oxidative Addition to (Biaryl)phosphine−Palladium Complexes via Density Functional Theory and Experimental Studies (2007)

We present results on the structure of monoligated active catalysts based upon 2-dicyclohexylphosphino-2‘,6‘-dimethoxybiphenyl (SPhos, 1) and 2-dicyclohexylphosphino-2‘,4‘,6‘-triisopropylbiphenyl (XPhos, 2) with Pd(0). Additionally, the reaction of SPhos·Pd with chlorobenzene has been explored via all-atom density functional theory (DFT) and these results are supported by NMR studies. The same reaction, but with a catalyst based on a larger ligand, XPhos·Pd, is also analyzed. Finally, it has been determined that inclusion of the entire ligand structure in these types of calculations is of importance for obtaining accurate and significant results.
Autonomous dual-mode (PAM2/4) serial link transceiver with adaptive equalization and data recovery (2005)

This paper describes an adaptively equalized, dual-mode (PAM2 one-tap DFE/PAM4) 0.13 /spl mu/m CMOS transceiver chip, and the techniques used to continuously adapt the link. Interestingly, with only minor modification the same hardware needed to implement a PAM4 system can be used to implement a PAM2 loop-unrolled single-tap decision-feedback equalization (DFE) receiver. Adaptive equalization using data-based update filtering allows continuous updates while minimizing the required sampler front-end hardware and significantly reduces the cost of implementation in multi-level signaling schemes. To allow the transmitter to adapt to the channel, the link uses common-mode signaling to create a back-channel communication path over the existing pair of wires. The design uses a three-level return-to-null signaling scheme which allows the receiver to simultaneously extract voltage and timing references and minimize the required receiver hardware. The measured results indicate that this back-channel achieves reliable communication without noticeable impact on the forward link for back-channel data rates of up to 16 Mb/s and swings of 20-100 mV.
Development of a high speed X-ray tomography system for multiphase flow imaging (1999)

This paper describes a new system for quantitative measurement of multiphase flow. It is based on the use of high speed (50 frames per second) X-ray tomographic imaging. This requires a new X-ray tube concept to be implemented, together with an annular detector array and data acquisition system. A pressurised krypton microgap detector is being developed to give 90% quantum efficiency for detection of K/sub /spl alpha// radiation from the silver anode X-ray tube. Results from simulation work are presented to justify the overall design strategy selected.
A plasmonic hybrid nanostructure with controlled interaction strength (2013)

We describe a novel plasmonic hybrid nanostructure based on a silver island film covered with a dielectric silica layer. The thickness of the silica layer is varied from 0 to approximately 46 nm on a single sample, thus allowing for continuous variation of the interaction strength between plasmon excitations in the metallic film and the excited states of pigments comprising photosynthetic complexes used to probe this interaction. While the largest separation between the silver film and photosynthetic complexes provides fluorescence featuring mono-exponential decay, thinner silica spacer distances show bi-exponential decay. The intensity of the fast component, which is attributed to the emission of photosynthetic complexes coupled to plasmon excitations, strongly decreases as a function of the spacer thickness. The interaction is stronger for excitation wavelengths resonant with plasmon absorption in the metallic layer. Full Text: PDF References P. Anger, P. Bharadwaj, L. Novotny, "Enhancement and Quenching of Single-Molecule Fluorescence", Phys. Rev. Lett. 96, 113002 (2006). CrossRef M.A. Noginov, G. Zhu, M. Bahoura, C.E. Small, C. Davison, J. Adegoke, V.P. Drachev, P. Nyga, V.M. Shalaev, "Enhancement of spontaneous and stimulated emission of a rhodamine 6G dye by an Ag aggregate", Phys. Rev. B 74, 184203 (2006). CrossRef K. Ray, R. Badugu, J. R. Lakowicz, "Metal-Enhanced Fluorescence from CdTe Nanocrystals:&thinsp; A Single-Molecule Fluorescence Study", J. Am. Chem. Soc. 128, 8998 (2006). CrossRef W. Zhang, Y. Chen, C. Hu, Y. Zhang, X. Chen, M. Qiu Zhang, "Effective excitation and control of guided surface plasmon polaritons in a conjugated polymer&ndash;silver nanowire composite system", J. Mater. Chem. C 1, 1265 (2013). CrossRef Ł. Bujak, N. Czechowski, D. Piatkowski, R. Litvin, S. Mackowski, T.H.P. Brotosudarmo, R.J. Cogdell, S. Pichler, W. Heiss, "Fluorescence enhancement of light-harvesting complex 2 from purple bacteria coupled to spherical gold nanoparticles", Appl. Phys. Lett. 99, 173701 (2011). CrossRef J.B. Nieder, R. Bittl, M. Brecht, "Fluorescence Studies into the Effect of Plasmonic Interactions on Protein Function", Angew. Chem. Int. Ed. 49, 10217 (2010). CrossRef P. Nyga, V. P. Drachev, M.D. Thoreson, V. M. Shalaev, "Mid-IR plasmonics and photomodification with Ag films", Appl. Phys. B 93, 59 (2008). CrossRef U.K. Chettiar, P. Nyga, M.D. Thoreson, A.V. Kildishev, V.P. Drachev, V.M. Shalaev, "FDTD modeling of realistic semicontinuous metal films", Appl. Phys. B 100, 159 (2010). CrossRef V.P. Drachev, M.D. Thoreson, V. Nashine, E.N. Khaliullin, D. Ben-Amotz, V.J. Davisson, V.M. Shalaev., "Adaptive silver films for surface-enhanced Raman spectroscopy of biomolecules", J. Raman Spectroscopy 36, 648 (2005). CrossRef B. Krajnik, T. Schulte, D. Piątkowski, N. Czechowski, E. Hofmann, S. Mackowski, "SIL-based confocal fluorescence microscope for investigating individual nanostructures", Cent. Eur. J. Phys. 9, 293 (2011). CrossRef
Lessons From the Adjuvant Bevacizumab Trial on Colon Cancer: What Next? (2010)

Eric Van Cutsem, University Hospital Gasthuisberg/Leuven, Katholieke Universiteit Leuven, Leuven, Belgium Diether Lambrechts, Vesalius Research Center, Vlaams Instituut voor Biotechnologie; Katholieke Universiteit Leuven, Leuven, Belgium Hans Prenen, University Hospital Gasthuisberg/Leuven, Katholieke Universiteit Leuven, Leuven, Belgium Rakesh K. Jain, Massachusetts General Hospital and Harvard Medical School, Boston, MA Peter Carmeliet, Vesalius Research Center, Vlaams Instituut voor Biotechnologie; Katholieke Universiteit Leuven, Leuven, Belgium
Regarding the Deceleration of the Universe (1996)

A proposed strategy for determining the deceleration parameter entails measuring the deviation from a linear (Hubble) distance-red shift relation. However, even at moderate red shifts, z &gt; 0.2, the deviation does not depend on q_0 alone, but also on the equation-of-state of the universe.
Venous thromboembolism complications in shoulder surgery: current concepts (2021)

Venous thromboembolism (VTE) is a rare yet known complication of shoulder surgery. Concerning shoulder arthroplasty, reported rates of VTE range from 0.2% to 16%. Unlike many lower extremity procedures, particularly total hip and knee arthroplasty, chemical prophylactic guidelines for VTE in shoulder surgeries have not been established. Some argue that doing so is unnecessary. On the contrary, mechanical prophylaxis is nearly universally accepted in shoulder surgery, particularly for more lengthy procedures. With limited VTE incidence in shoulder surgery, treatment is anecdotally derived from the hip and knee arthroplasty literature. Recent studies have successfully identified risk factors for VTE related to the patient and to the surgery itself. Awareness of these risk factors by the surgeon and declaration of these factors to the patient should be discussed as part of the informed consent process. Further investigational studies and larger patient cohorts will be necessary to optimise VTE prevention in shoulder surgeries.
Combinational American Thyroid Association: photoacoustic score as a novel classification method for thyroid cancer nodules in vivo (2021)

We report a novel photoacoustic (PA) scoring method for the risk stratification of thyroid nodules, which is combination of the American Thyroid Association (ATA) and PA malignancy probability. We performed multi-spectral PA imaging and multi-parametric PA analysis for thyroid cancer patients (23 malignancy and 29 benign cases). Initial multi-parametric PA analysis showed that malignancy of the thyroid nodules can be diagnosed with a 78% sensitivity and 93% specificity. Moreover, our novel score called ATAP improved the sensitivity to 83% while maintaining the specificity. The results suggest that the ATAP may help physicians examine thyroid nodules, thus reducing unnecessary biopsies.
ChemInform Abstract: A Novel Method for the Preparation of Lead Selenide: Pulse Sonoelectrochemical Synthesis of Lead Selenide Nanoparticles. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Michelson interferometry with 10 pm accuracy (2000)

We demonstrate a new heterodyne Michelson interferometer design for displacement measurements capable of fringe interpolation accuracy of one part in 36 000. Key to this level of accuracy are the use of two acousto-optic modulators for heterodyne frequency generation and digital signal processing demodulation electronics. We make a direct comparison of our interferometer to a commercial interferometer based on a Zeeman-stabilized laser, and show that the residual periodic errors in ours are two orders of magnitude lower than those in the commercial unit. We discuss electronically induced optical cross talk and optical feedback as sources of periodic error. Our new interferometer is simple, robust, and readily implemented.
Replication of avian leukosis viruses with mutations at the primer binding site: use of alternative tRNAs as primers (1995)

We have tested whether avian leukosis viruses (ALVs) can use tRNAs other than tRNATrp to initiate reverse transcription. The primer binding site (PBS) of a wild-type ALV provirus, which is complementary to the 3' end of tRNA(Trp), was replaced with sequences homologous to the 3' ends of six different chicken tRNAs (tRN(APro), tRNA(Lys), tRNA(Met), tRNA(Ile), tRNA(Phe), and tRNA(Ser)). Transfection of these proviruses into chicken embryo fibroblasts resulted in the production of infectious viruses, all of which apparently used the tRNA specified by the mutated PBS to replicate. However, growth of these viruses resulted in reversion to the wild-type (tRNA(Trp)) PBS. Some of the viruses revert quite quickly, while others are more stable. The relative stability of a given PBS correlated with the concentration of the corresponding tRNA in the virion. We determined the percentage of viral RNA that had a tRNA bound to the PBS and found that the occupancy rate is lower in the mutants than in the wild-type virus. We conclude that many different tRNAs can be used as primers to initiate reverse transcription in ALV. However, ALVs that use tRNA(Trp) have a growth advantage over ALVs that use other tRNAs.
Exclusion of the P75 neurotrophin receptor gene as a candidate gene for Meckel syndrome (1997)

Nerve growth factor receptor p75 (NGFR) gene was investigated as a potential candidate gene in Meckel syndrome (MKS) because of its important role in embryonic development, chromosomal localization adjacent to the MKS locus and Meckel syndrome-resembling findings in knock-out mice phenotype. The sequence analysis of the coding region of the gene revealed one polymorphism but no potential disease mutation. Physical mapping of the critical chromosomal region finally showed that the NGFR gene lies outside the MKS locus.
An unexpected synthesis of ketene monothioacetals (2006)

Some dithiocarbonates (xanthates) can be converted into ketene monothioacetals through extrusion of sulfur upon treatment with base and an alkylating agent.