gebhart/patrepeval huggingface dataset:
Manipulation of organolanthanide coordinative unsaturation. Synthesis, structures, structural dynamics, comparative reactivity, and comparative thermochemistry of dinuclear .mu.-hydrides and .mu.-alkyls with [.mu.-R2Si(Me4C5)(C5H4)]2 supporting ligation (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTManipulation of organolanthanide coordinative unsaturation. Synthesis, structures, structural dynamics, comparative reactivity, and comparative thermochemistry of dinuclear .mu.-hydrides and .mu.-alkyls with [.mu.-R2Si(Me4C5)(C5H4)]2 supporting ligationDavid Stern, Michal Sabat, and Tobin J. MarksCite this: J. Am. Chem. Soc. 1990, 112, 26, 9558–9575Publication Date (Print):December 1, 1990Publication History Published online1 May 2002Published inissue 1 December 1990https://pubs.acs.org/doi/10.1021/ja00182a015https://doi.org/10.1021/ja00182a015research-articleACS PublicationsRequest reuse permissionsArticle Views655Altmetric-Citations157LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Oxygen dissolution and transport in cobaltporphyrin‐bound organophosphazene membranes (1993)

Abstract Rubbery poly(organophosphazene)s were synthesized, and were combined with cobaltporphyrin (CoP) which binds molecular oxygen rapidly and reversibly. The apparent oxygen‐binding equilibrium constant (K app ) is in proportion to the physical solubility coefficient of oxygen in the polymer, although the reduced equilibrium and thermodynamic parameters are not dependent on the polymer matrix species. Diffusivity of oxygen via the fixed CoP(D C ) is enhanced for poly(organophosphazene) membranes with a larger oxygen diffusion constant. Poly(organophosphazene) membranes with both a large K app and D C yield high oxygen permeability.
Comparison of outcomes in infected cardiovascular implantable electronic devices between complete, partial, and failed lead removal: an ESC-EHRA-EORP ELECTRa (European Lead Extraction ConTrolled) registry (2019)

A total of 6.5% of infected CIED patients failed attempted extraction. Only were >4 cm of lead remained resulted in higher procedural complications and mortality rates.
A Low Profile Dual Polarized Slot Coupled Patch Antenna (2018)

A low profile, dual polarized, slot coupled patch antenna is designed and developed in this paper. The antenna has a measured bandwidth of 17.2% for return loss &gt; 15 dB and pair ports isolation &gt;23 dB. The gain of the antenna is over 10 dBi and the half power beam widths (HPBW) of the antenna are 80±3<sup>o</sup> in the horizontal plane and 39±2<sup>o</sup> in the vertical plane. The cross polarization discrimination (XPD) is less than 20 dB in HPBW. Within the operating band, the performances of good impedance match, high ports isolation, low cross polarization, and stable radiation patterns are achieved.
Chiral Salicyloxazolines as Auxiliaries for the Asymmetric Synthesis of Ruthenium Polypyridyl Complexes (2010)

Chiral auxiliaries are promising emerging tools for the asymmetric synthesis of octahedral metal complexes. We recently introduced chiral salicyloxazolines as coordinating bidentate chiral ligands which provide excellent control over the metal-centered configuration in the course of ligand substitution reactions and can be removed afterward in an acid-induced fashion under complete retention of configuration (J. Am. Chem. Soc. 2009, 131, 9602-9603). Here reported is our detailed investigation of this sequence of reactions, affording virtually enantiopure ruthenium polypyridyl complexes. The control of the metal-centered chirality by the coordinated chiral salicyloxazolinate ligand was evaluated as a function of reaction conditions, the employed bidentate 2,2'-bipyridine and 1,10-phenanthroline ligands, and the substituent at the asymmetric 5-position of the oxazoline heterocycle. Most striking was the strong influence of the reaction solvent, with aprotic solvents of lower polarity providing the most favorable diastereoselectivities. Through a combination of computational and experimental results, it was revealed that the observed stereoselectivities are under thermodynamic control. The removal of the chiral salicyloxazoline auxiliary under retention of the configuration requires acidic conditions and a coordinating solvent such as MeCN or THF in order to prevent partial racemization. This method represents the first general strategy for the asymmetric synthesis of enantiopure heteroleptic ruthenium polypyridyl complexes.
Novel T Cell-Engaging, Bispecific Antibodies for Depletion of Human Immunodeficiency Virus-Infected Cells (2015)

To analyze HIV envelope protein (env) specific BiTE antibody constructs for their potential to lyse infected cells, antibody specificities and human CD4, as env receptor, were put into BiTE format. BiTE antibody constructs were tested in vitro showing a nM affinity to env and mediated lysis of transfected cells at pM levels. On infected cells, the CD4 BiTE inhibited viral replication at nM levels. The CD4 BiTE significantly reduced the viral load in mice engrafted with infected human PBMCs. To increase the BiTE half-life, fusions with a serum albumin binding peptide were tested in vitro at which the C-terminally tagged CD4 BiTE showed the best bioactivity.
Continuous Flow Oxidation of Alcohols and Aldehydes Utilizing Bleach and Catalytic Tetrabutylammonium Bromide (2011)

We report a method for the oxidation of a range of alcohols and aldehydes utilizing a simple flow system of alcohols in EtOAc with a stream of 12.5% NaOCl and catalytic Bu4NBr. Secondary alcohols are oxidized to ketones, aldehydes are oxidized directly to methyl esters in the presence of methanol, and benzylic alcohols are oxidized to either benzaldehydes or methyl esters, depending on the conditions used. The reaction conditions are mild and generally provide complete conversion in 5–30 min.
Development and Implementation of an Internal Quality Control Sample to Standardize Oligomer-Based Diagnostics of Alzheimer’s Disease (2023)

Protein misfolding and aggregation are pathological hallmarks of various neurodegenerative diseases. In Alzheimer's disease (AD), soluble and toxic amyloid-β (Aβ) oligomers are biomarker candidates for diagnostics and drug development. However, accurate quantification of Aβ oligomers in bodily fluids is challenging because extreme sensitivity and specificity are required. We previously introduced surface-based fluorescence intensity distribution analysis (sFIDA) with single-particle sensitivity. In this report, a preparation protocol for a synthetic Aβ oligomer sample was developed. This sample was used for internal quality control (IQC) to improve standardization, quality assurance, and routine application of oligomer-based diagnostic methods. We established an aggregation protocol for Aβ1-42, characterized the oligomers by atomic force microscopy (AFM), and assessed their application in sFIDA. Globular-shaped oligomers with a median size of 2.67 nm were detected by AFM, and sFIDA analysis of the Aβ1-42 oligomers yielded a femtomolar detection limit with high assay selectivity and dilution linearity over 5 log units. Lastly, we implemented a Shewhart chart for monitoring IQC performance over time, which is another important step toward quality assurance of oligomer-based diagnostic methods.
Regenerative Shock Absorbers and the Role of the Motion Rectifier (2016)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The development of suspension systems has seen substantial improvements in the last years due to the use of variable dampers. Furthermore, the efficiency increase in the subsystems within the automotive chassis has led to the use of regenerative solutions, in which electric machines can be employed as generators to recover part of the energy otherwise dissipated. However, the harvesting capability of regenerative suspensions is often limited by friction and inertial phenomena. The former ones waste mechanical energy into heat, while the latter ones hamper the shock absorption by locking the suspension when subject to dynamic excitation. Besides a suitable design and sizing of components, recent research works highlight the use of the so-called motion rectifier to improve energy recovery by constraining the motion of the electric motor to a single sense of rotation. This strategy can potentially reduce inertial issues related to zero-speed crossing and motion inversion, thus leading to better conversion efficiency. Although results in literature indicate favorable damping characteristics of the shock absorbers equipped with this device, the real advantages introduced by the motion rectifier are yet to be quantified. In this context, the present paper aims to analyze hydraulic regenerative shock absorbers with the particular goal of putting in evidence the benefits and implications introduced by the use of the motion rectifier. Quantitative results from accurate modeling and simulation highlight the capabilities of the device in terms of harvested power, conversion efficiency, comfort and road holding.&lt;/div&gt;&lt;/div&gt;
Mean-square-error optimality of orthogonal space-time block codes (2003)

Linear space-time block coding (STBC) is a conceptually simple transmission technique for channels with multiple transmit and receive antennas. We study a subclass of linear STBC, namely orthogonal STBC (OSTBC), with the primary goal of contributing toward a complete understanding of OSTBC. In particular, we prove that OSTBC is optimal in a minimum mean-square-error (MSE) sense, provided that a zero-forcing detector is used at the receiver. As a by-product, we also obtain a concise characterization of linear and orthogonal STBCs as well as the relationship between them. The MSE optimality of OSTBC can be used as a way of introducing this coding scheme from first principles.
Chromosome instability and benefit from adjuvant anthracyclines in breast cancer (2012)

CIN is of prognostic significance and may be of predictive value in determining anthracycline response, although further testing is required.
A Sigma-Delta closed-loop digital microfluxgate magnetometer (2006)

This paper presents the concept and the design of a new architecture for microfluxgate sensors. An innovative low-pass architecture based on pulsed excitation is presented, with a ΣΔ-based closed-loop measurement circuit including digital and semi-digital filters. While the total power consumption is reduced to about 20mW, it also allows a power/resolution tradeoff for a digitally-controlled tunable magnetometer.
MiRNA-Related Genetic Variations Associated with Radiotherapy-Induced Toxicities in Patients with Locally Advanced Non–Small Cell Lung Cancer (2016)

Severe radiation-induced toxicities limit treatment efficacy and compromise outcomes of lung cancer. We aimed to identify microRNA-related genetic variations as biomarkers for the prediction of radiotherapy-induced acute toxicities. We genotyped 233 SNPs (161 in microRNA binding site and 72 in processing gene) and analyzed their associations with pneumonitis and esophagitis in 167 stage III NSCLC patients received definitive radiation therapy. Sixteen and 11 SNPs were associated with esophagitis and pneumonitis, respectively. After multiple comparison correction, RPS6KB2:rs10274, SMO:rs1061280, SMO:rs1061285 remained significantly associated with esophagitis, while processing gene DGCR8:rs720014, DGCR8:rs3757, DGCR8:rs1633445 remained significantly associated with pneumonitis. Patients with the AA genotype of RPS6KB2:rs10274 had an 81% reduced risk of developing esophagitis (OR: 0.19, 95% CI: 0.07-0.51, p = 0.001, q = 0.06). Patients with the AG+GG genotype of SMO:rs1061280 had an 81% reduced risk of developing esophagitis (OR: 0.19, 95% CI: 0.07-0.53, p = 0.001, q = 0.06). Patients with the GG+GA genotype of DGCR8:rs720014 had a 3.54-fold increased risk of pneumonitis (OR: 3.54, 95% CI: 1.65-7.61, p <0.05, q <0.1). Significantly cumulative effects of the top SNPs were observed for both toxicities (P-trend <0.001). Using bioinformatics tools, we found that the genotype of rs10274 was associated with altered expression of the RPS6KB2 gene. Gene-based analysis showed DGCR8 (p = 0.010) and GEMIN4 (p = 0.039) were the top genes associated with the risk of developing pneumonitis. Our results provide strong evidence that microRNA-related genetic variations contribute to the development of radiotherapy-induced acute esophagitis and pneumonitis and could thus serve as biomarkers to help accurately predict radiotherapy-induced toxicity in NSCLC patients.
A Phase I Safety, Pharmacokinetic, and Pharmacodynamic Presurgical Trial of Vitamin E δ-tocotrienol in Patients with Pancreatic Ductal Neoplasia (2015)

VEDT from 200 to 1600 mg daily taken orally for 2 weeks before pancreatic surgery was well tolerated, reached bioactive levels in blood, and significantly induced apoptosis in the neoplastic cells of patients with pancreatic ductal neoplasia. These promising results warrant further clinical investigation of VEDT for chemoprevention and/or therapy of pancreatic cancer.
Difference frequency laser spectroscopy of the ν3 fundamental band of NH+2 (1989)

The ν3 band of NH+2 in the X̃ 3B1 ground electronic state was observed in direct absorption with a tunable difference frequency laser spectrometer in the 3 μ region, using velocity modulation detection. NH+2 and NH+3 ions were generated in an ac discharge of He and NH3, or of He, N2, and H2. Fifty-three rovibrational transitions were measured and fit to a triplet A-reduced Hamiltonian to determine rotational, centrifugal distortion, and spin–rotation constants. The band origin was found to be ν0=3359.932 cm−1, in excellent agreement with a recent calculation of Jensen, Bunker, and McLean. Indirect evidence from the spectrum suggested that NH+2 is quasilinear, but selection rules prevented a determination of the A rotational constant.
A prequential approach to regression estimation (2002)

Prequential model selection is a data-driven methodology for selecting between rival models on the basis of their predictive ability where the predictive ability of a model is measured by its accumulated prediction error on a given set of observations. Given i.i.d. observations, we propose a regression estimator-based on neural networks-that selects the number of "hidden units" using prequential model selection, and establish a rate of convergence for the statistical risk of the proposed estimator.
A cochlear model using the time-averaged Lagrangian and the push-pull mechanism in the organ of Corti (2009)

In our previous work, the basilar membrane velocity V(BM) for a gerbil cochlea was calculated and compared with physiological measurements. The calculated V(BM) showed excessive phase excursion and, in the active case, a best-frequency place shift of approximately two fifths of an octave higher. Here we introduce a refined model that uses the time-averaged Lagrangian for the conservative system to resolve the phase excursion issues. To improve the overestimated best-frequency place found in the previous feed-forward active model, we implement in the new model a push-pull mechanism from the outer hair cells and phalangeal process. Using this new model, the V(BM) for the gerbil cochlea was calculated and compared with animal measurements, The results show excellent agreement for mapping the location of the maximum response to frequency, while the agreement for the response at a fixed point as a function of frequency is excellent for the amplitude and good for the phase.
Characterization and Optimization Technique for Microwave-Driven High-Intensity Discharge Lamps Using Hot <formula formulatype="inline"> <tex Notation="TeX">${S}$</tex></formula>-Parameters (2014)

High-intensity discharge lamps can be driven by radio-frequency signals in the ISM frequency band at 2.45 GHz, using a matching network to transform the impedance of the plasma to the source impedance. To achieve an optimal operating condition, a good characterization of the lamp in terms of radio frequency equivalent circuits under operating conditions is necessary, enabling the design of an efficient matching network. This paper presents the characterization technique for such lamps and presents the design of the required matching network. For the characterization, a high-intensity discharge lamp was driven by a monofrequent large signal at 2.45 GHz, whereas a frequency sweep over 300 MHz was performed across this signal to measure so-called small-signal hot S-parameters using a vector network analyzer. These parameters are then used as an equivalent load in a circuit simulator to design an appropriate matching network. Using the measured data as a black-box model in the simulation results in a quick and efficient method to simulate and design efficient matching networks in spite of the complex plasma behavior. Furthermore, photometric analysis of high-intensity discharge lamps are carried out, comparing microwave operation to conventional operation.
Automating Experience: Does the ‘automated home’ diminish or deepen user experience? (2016)

In a technologically streamlined world, our dominant version of reality comes with the majority of problems mitigated through the constant and rapid evolution of technology systems. One notable progression is that of automating technologies within the home, which have been suggested deliver rich experiences that are both immersive and smart.The vision for automated living spaces sees people interacting easily within digital environments where by electronics are sensitive to our needs, personalised to requirements, anticipatory of behaviour and responsive to our presence all enabled by the extraordinary potential of the Internet of Things. There are significant benefits that accompany these forms of development. Yet, for all its affordances, there are larger issues concerning agency still to be explored.Hosted in partnership with Philips Lighting and the University of Brighton, this conversation explores the relationships between the automated home and user experience, asking: Does the automated home diminish or deepen user experience?
Deciphering the Contributions of Volcanic and Environmental Events to Temporal Variations of the Regional Velocity Structure at the Kluchevskoy Volcano Group (Kamchatka, Russia) (2022)

&amp;lt;p&amp;gt;Kamchatka, a remote peninsula in eastern Russia, is home to the Kluchevskoy volcano group, one of the largest and most active clusters of subduction zone volcanoes worldwide. Regular eruptions, volcanic and tectonic earthquakes, but also strong meteorological variations leave an imprint on the regional seismic velocity structure. We quantify the temporal velocity variations by applying the method of ambient seismic noise interferometry to waveform data recorded by the temporary KISS deployment and the permanent Kamchatka network. Due to its ubiquitous nature, ambient seismic noise allows for far denser temporal sampling than, e.g., active source or earthquake coda interferometry. However, source variability related, for example, to volcanic tremor activity affects the results retrieved by this method and can lead to decreased reliability. Here, we investigate the impact of the aforementioned environmental factors on the Green&amp;amp;#8217;s function of the medium using SeisMIC (Seismological Monitoring using Interferometric Concepts) &amp;amp;#8211; a new Python software to conduct noise interferometry surveys. In addition, we discuss the impact of the frequent volcanic tremors and other local seismic events on the stability of the computed Green&amp;amp;#8217;s function estimations (i.e., cross-correlations).&amp;lt;/p&amp;gt;
Cryopreservation of Oocytes by Slow Freezing (2017)

Cryopreservation of Oocytes by Slow Freezing PrincipleOocyte cryopreservation involves freezing unfertilized eggs from a patient for subsequent thawing, fertilization, and embryo transfer.Several types of patients may benefit from oocyte cryopreservation.Patients, especially single women, who are undergoing medical treatments, such as chemotherapy, may be at risk of irreversible loss of ovarian function.Such women may wish to freeze oocytes in an attempt to preserve fertility.Women undergoing Assisted Reproductive Technology (ART) procedures, but who have ethical or other concerns about embryo freezing, may opt to freeze oocytes.Note: This procedure is no longer used to freeze oocytes since the change to vitrification of oocytes in 2007.It will remain in the procedure manual as a backup method and reference for oocytes frozen using this method.
Protective effects of taurine on human hair follicle grownin vitro1 (2006)

Taurine is a naturally occurring beta-amino acid produced by methionine and cysteine metabolism. It is involved in a variety of physiological functions, including immunomodulatory and antifibrotic. Taking advantage of the ability of human hair follicle grown in vitro to recapitulate most of the characteristic features of normal hair follicle in vivo, we studied (i) taurine uptake by isolated human hair follicles; (ii) its effects on hair growth and survival rate; and (iii) its protective potential against transforming growth factor (TGF)-beta1, an inhibitor of in vitro hair growth and a master switch of fibrotic program. We showed that taurine was taken up by the connective tissue sheath, proximal outer root sheath and hair bulb, promoted hair survival in vitro and prevented TGF-beta1-induced deleterious effects on hair follicle.
Entangling Quantum Memories via Heralded Photonic Bell Measurement (2023)

A common way to entangle quantum memories is via photonic entanglement swaps. Each of two memories, connected by an optical channel, emits a photonic qubit entangled with itself, and the photonic qubits undergo an entanglement swap on a beamsplitter in the middle of the channel. We compare two choices of encoding of the photonic qubit: single rail and dual rail. At low channel loss the dual-rail scheme outperforms the single rail scheme. However, as expected, the high-loss rate asymptote for the dual rail scheme scales quadratically worse with loss compared with single rail. Considering the following non-idealities: imperfect mode matching at the swap, carrier-phase mismatch across the interfered photonic qubits, and detector excess noise, we evaluate the density operator of the heralded two-qubit entangled state. We calculate a lower bound on its distillable entanglement per copy, and its Fidelity (with the ideal Bell state). For both schemes, imperfect swap-visibility results in a constant-factor decrease in the rate, while excess noise results in a dropoff of distillable entanglement beyond a certain total channel loss threshold, to zero. Despite the single-rail scheme's better rate-loss scaling, it is more severely affected by excess noise. The single-rail scheme is adversely affected by stochastic carrier-phase mismatch, which does not affect the dual-rail scheme. We study entanglement distillation on the heralded noisy entangled states for both methods, and outline a suite of quantum networking studies that our work could incite.