gebhart/patrepeval huggingface dataset:
Fast and reliable top-level simulation strategy for mixed-signal integrated circuits and its application to DC–DC converters (2007)

Top-level, transient, transistor-based simulations are a critical step in the product-development cycle of mixed-signal integrated circuits. These simulations are normally performed just before fabrication and unfortunately impose cumbersome bottlenecks in the design flow. Verification is an iterative process by nature, whereby each problem found requires another simulation to ensure a proper fix is in place, and because of the complexity of a large system, minor errors can cost days, increasing design time and time-to-market. A top-level transistor-based simulation strategy is proposed with minimal time overhead. The strategy is to start with a quick, all macro-model system simulation and gradually substitute one transistor-level sub-block at a time for each additional run. For optimal results, less computationally intensive blocks, which can be determined from a proposed set of screening simulations, are replaced first. The proposed strategy was tested and applied to a buck, current-mode switching regulator, and the results show that simulation overhead is least for linear analogue functions (e.g. op-amps) and worst for high-speed nonlinear circuits (e.g. signal generators). Nonlinear and bi-stable analogue blocks such as bandgap references take more time to simulate than op-amps and less than low frequency digital functions such as power-on-reset, which in turn are less intensive than ramp and pulse generators.
A 2D/3D hybrid integral imaging display by using fast switchable hexagonal liquid crystal lens array (2017)

The paper proposes a new display which could switch 2D and 3D images on a monitor, and we call it as Hybrid Display. In 3D display technologies, the reduction of image resolution is still an important issue. The more angle information offer to the observer, the less spatial resolution would offer to image resolution because of the fixed panel resolution. Take it for example, in the integral photography system, the part of image without depth, like background, will reduce its resolution by transform from 2D to 3D image. Therefore, we proposed a method by using liquid crystal component to quickly switch the 2D image and 3D image. Meanwhile, the 2D image is set as a background to compensate the resolution.. In the experiment, hexagonal liquid crystal lens array would be used to take the place of fixed lens array. Moreover, in order to increase lens power of the hexagonal LC lens array, we applied high resistance (Hi-R) layer structure on the electrode. Hi-R layer would make the gradient electric field and affect the lens profile. Also, we use panel with 801 PPI to display the integral image in our system. Hence, the consequence of full resolution 2D background with the 3D depth object forms the Hybrid Display.
Observation of Floquet Chern insulators of light (2023)

The field of topological photonics studies unique and robust photonic systems that are immune to defects and disorders due to the protection of their underlying topological phases. Mostly implemented in static systems, the studied topological phases are often defined in linear photonic band structures. In this study, we experimentally demonstrate Floquet Chern insulators in periodically driven nonlinear photonic crystals, where the topological phase is controlled by the polarization and the frequency of the driving field. Mediated by strong material nonlinearity, our system enters what we call the 'strong Floquet coupling regime', where the photonic Floquet bands cross and open new energy gaps with non-trivial topology as observed in our transient sum-frequency generation measurements. Our work offers new opportunities to explore the role of classical optical nonlinearity in topological phases and their applications in nonlinear optoelectronics.
Data from XPO1 (CRM1) Inhibition Represses STAT3 Activation to Drive a Survivin-Dependent Oncogenic Switch in Triple-Negative Breast Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;Inhibition of XPO1 (CRM1)-mediated nuclear export of multiple tumor suppressor proteins has been proposed as a novel cancer therapeutic strategy to turn off oncogenic signals and enhance tumor suppression. Survivin is a multifunctional protein with oncogenic properties when expressed in the cytoplasm that requires the XPO1–RanGTP complex for its nuclear export. We investigated the antitumor mechanisms of the drug-like selective inhibitors of nuclear export (SINE) XPO1 antagonists KPT-185, KPT-251 KPT-276, and KPT-330 in estrogen receptor–positive and triple-negative breast cancer (TNBC) cell lines and xenograft models of human breast tumors. KPT compounds significantly inhibited breast cancer cell growth and induced tumor cell death, both &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;. These drugs initially promoted survivin accumulation within tumor cell nuclei. However, their major &lt;i&gt;in vitro&lt;/i&gt; effect was to decrease survivin cytoplasmic protein levels, correlating with the onset of apoptosis. XPO1 inhibition repressed &lt;i&gt;Survivin&lt;/i&gt; transcription by inhibiting CREB-binding protein-mediated STAT3 acetylation, and blocking STAT3 binding to the &lt;i&gt;Survivin&lt;/i&gt; promoter. In addition, caspase-3 was activated to cleave survivin, rendering it unavailable to bind X-linked inhibitor of apoptosis protein and block the caspase cascade. Collectively, these data demonstrate that XPO1 inhibition by SINE compounds represses STAT3 transactivation to block the selective oncogenic properties of survivin and supports their clinical use in TNBC. &lt;i&gt;Mol Cancer Ther; 13(3); 675–86. ©2014 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
A Novel Topology for Solar PV Inverter Based on an LLC Resonant Converter With Optimal Frequency and Phase-Shift Control (2022)

In this article, a new topology for a grid-connected solar photovoltaic inverter for the direct connection to the medium-voltage grid is proposed. This topology employs an <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LLC</i> resonant converter with a high-frequency (HF) isolation transformer in the dc–dc stage. The output of the dc–dc stage is a rectified sine wave voltage and current at the line frequency. An unfolder inverter interfaces between this dc stage and the grid. A combined phase-shift and frequency control method is used to control the <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LLC</i> resonant converter. The phase-shift angle and switching frequency values of the <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LLC</i> resonant converter are regulated to track the reference current signal for the whole operation range. The Lagrange multiplier method is applied to find the optimal trajectory to calculate the optimal phase-shift angle and switching frequency pairs for any operation condition by considering power converter and HF transformer losses to achieve the highest efficiency at a varying current. The transformer leakage and magnetization inductances are properly designed to provide a zero-voltage switching (ZVS) for a wide operation area, and additional resonant inductor requirement is removed. The <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LLC</i> converter operates in a ZVS region except in a narrow band around the zero-current crossings of the inverter output. Using an HF transformer in the <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LLC</i> resonant converter, a bulky line frequency transformer requirement is eliminated, and thus, a more compact and efficient design is obtained. The proposed topology is validated by the simulation and experimental results.
Aluminum-Catalyzed Asymmetric Addition of TMSCN to Aromatic and Aliphatic Ketones Promoted by an Easily Accessible and Recyclable Peptide Ligand (2002)

Easily prepared peptide-based ligands efficiently promote the Al-catalyzed enantioselective addition of trimethylsilyl cyanide (TMSCN) to aromatic, aliphatic, cyclic, and acyclic ketones (see scheme for an example). The chiral ligands can be readily recovered and reused without loss of activity or selectivity.
Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and Tumor Cell Movements (2018)

Syntaphilin (SNPH) inhibits the movement of mitochondria in tumor cells, preventing their accumulation at the cortical cytoskeleton and limiting the bioenergetics of cell motility and invasion. Although this may suppress metastasis, the regulation of the SNPH pathway is not well understood. Using a global proteomics screen, we show that SNPH associates with multiple regulators of ubiquitin-dependent responses and is ubiquitinated by the E3 ligase CHIP (or STUB1) on Lys111 and Lys153 in the microtubule-binding domain. SNPH ubiquitination did not result in protein degradation, but instead anchored SNPH on tubulin to inhibit mitochondrial motility and cycles of organelle fusion and fission, that is dynamics. Expression of ubiquitination-defective SNPH mutant Lys111→Arg or Lys153→Arg increased the speed and distance traveled by mitochondria, repositioned mitochondria to the cortical cytoskeleton, and supported heightened tumor chemotaxis, invasion, and metastasis <i>in vivo</i> Interference with SNPH ubiquitination activated mitochondrial dynamics, resulting in increased recruitment of the fission regulator dynamin-related protein-1 (Drp1) to mitochondria and Drp1-dependent tumor cell motility. These data uncover nondegradative ubiquitination of SNPH as a key regulator of mitochondrial trafficking and tumor cell motility and invasion. In this way, SNPH may function as a unique, ubiquitination-regulated suppressor of metastasis.<b>Significance:</b> These findings reveal a new mechanism of metastasis suppression by establishing the role of SNPH ubiquitination in inhibiting mitochondrial dynamics, chemotaxis, and metastasis. <i>Cancer Res; 78(15); 4215-28. ©2018 AACR</i>.
Vascular smooth muscle cells from injured rat aortas display elevated matrix production associated with transforming growth factor-beta activity. (1995)

The arterial response to injury is characterized by a short period of increased proliferation and migration of vascular smooth muscle cells, followed by an extended period of extracellular matrix accumulation in the intima. Transforming growth factor-beta (TGF-beta) has been implicated as a causative factor in the formation of extracellular matrix in this process, which leads to progressive thickening of the intima, known as intimal hyperplasia. In vitro analysis of vascular smooth muscle cells harvested from normal rat aortas and from aortas injured 14 days earlier showed that both types of cells attached equally well to culture dishes but that the initial spreading of the cells was increased in cells derived from injured vessels. Cells from the injured arteries produced more fibronectin and proteoglycans into the culture medium than the cells from normal arteries and contained more TGF-beta 1 mRNA. TGF-beta 1 increased proteoglycan synthesis by normal smooth muscle cells, and the presence of a neutralizing anti-TGF-beta 1 antibody reduced proteoglycan synthesis by the cells from injured arteries in culture. Fibronectin synthesis was not altered by these treatments. These results indicate that the accumulation of extracellular matrix components in neointimal lesions is at least partially caused by autocrine TGF-beta activity in vascular smooth muscle cells.
Ultracap – Based New Electrical Drives For Off-Road Vehicles And Rovers (2003)

By means of results of experimental tests and of theoretical considerations the paper analyses the benefits given by supercaps used as auxiliary supplying devices in road and off-road electrical vehicles. The authors show how small sets of supercaps increase electrochemical batteries life and fuel distance, because they are capable of supporting transient current peaks and of regenerating electrical energy with higher efficiency than traditional batteries. Due to the characteristics of supercaps and electrical batteries, i.e. mainly to their inner resistances, to their energy/weight and energy/volume ratios the compound use of both components must be properly balanced to obtain concrete improvements of system performances. A sample designing procedure is suggested in the paper, based on the duty-cycles of vehicles. It evaluates the battery and supercap ratings required to obtain a compound set which covers the full power requested by the load without overloading the battery.
Improved efficiency of asymmetric hydrolysis of 3-substituted glutaric acid diamides with an engineered amidase (2016)

Increasing the efficiency of hydrolysis of 3-substituted glutaric acid diamides is useful to improve the synthesis of optically active 3-substituted gamma-aminobutyric acid. This is the first report of efficient hydrolysis of CGD using amidase mutant-producing E. coli cells.
Production of High‐Quality Diesel from Biomass Waste Products (2011)

Hochwertige Flüssigtreibstoffe werden mithilfe energieeffizienter Prozesse aus nicht essbaren Kohlenhydraten gewonnen. Durch Hydrierung von Furfural erhaltenes 2-Methylfuran wird in einem lösungsmittelfreien katalytischen Verfahren in 6-Alkylundecane wie 6-Butylundecan umgewandelt. Der Prozess liefert einen Diesel-Treibstoff mit ausgezeichneter Cetanzahl (71) und einem Pourpoint von −90 °C, wobei Gesamtumsatz und -selektivität nahe 90 % liegen. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Fixed-point frequencies analysis of monolithic 10 GHz repetition rates AlGaInAs multiple quantum-well laser diodes (2017)

We report the first conducted measurements of the fixed-point frequencies on a 10 GHz repetition rate mode locked laser diode functioning at 1.55 μm wavelength. The measurements show that four unique laser parameters can be modulated to independently control the combline offset frequency, V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> , and comb spacing, f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rep</sub> .
Welcome and Introduction to SPIE Conference 11681 (2021)

Introduction to SPIE Photonics West OPTO conference 11681: Physics, Simulation, and Photonic Engineering of Photovoltaic Devices X.
Reduction in the Thermal Conductivity of Single Crystalline Silicon by Phononic Crystal Patterning (2010)

Phononic crystals (PnCs) are the acoustic wave equivalent of photonic crystals, where a periodic array of scattering inclusions located in a homogeneous host material causes certain frequencies to be completely reflected by the structure. In conjunction with creating a phononic band gap, anomalous dispersion accompanied by a large reduction in phonon group velocities can lead to a massive reduction in silicon thermal conductivity. We measured the cross plane thermal conductivity of a series of single crystalline silicon PnCs using time domain thermoreflectance. The measured values are over an order of magnitude lower than those obtained for bulk Si (from 148 W m(-1) K(-1) to as low as 6.8 W m(-1) K(-1)). The measured thermal conductivity is much smaller than that predicted by only accounting for boundary scattering at the interfaces of the PnC lattice, indicating that coherent phononic effects are causing an additional reduction to the cross plane thermal conductivity.
Single-Phase Transformer-less Photovoltaic Inverter Featuring Low Common-Mode Voltage Noise Generation Enabled by an AC-decoupling and DC-link Mid-point Clamping Technique (2021)

This paper studies a single-phase transformerless photovoltaic (PV) inverter featuring AC-decoupling and midpoint DC-link clamping technique which enables a low common-mode voltage noise generation. This circuit is well-suited for PV residential applications. The characteristics of this circuit topology, the principles of operation, and the main dimensioning equations are described in this paper. Finally, simulation and experimental results are used to verify the characteristics of the studied converter.
Low‐Oxidized Siloxene Nanosheets with High Capacity, Capacity Retention, and Rate Capability in Lithium‐Based Batteries (2022)

Abstract The mechanical degradation experienced by Si electrodes during Li (de)alloying reactions can potentially be mitigated by using Si‐based materials with layered 2D geometries. Such materials are expected to exhibit favorable mechanical properties and be capable of buffering the volume change associated with (de)lithitation. In this work, 2D siloxene nanosheets are synthesized using a facile topotactic reaction followed by ultrasonication as an exfoliation step. Detailed structural and chemical characterization via electron microscopy, X‐ray photoelectron spectroscopy (XPS), and Raman spectroscopy is conducted, revealing a low‐oxidized siloxene nanosheet material with only 15% surface Si‐oxide. The obtained siloxene nanosheets are tested as Li‐ion negative electrodes in lithium‐based electrochemical cells. The cells exhibit high rate capability with a capacity of 935 mAh g –1 at 3200 mA g –1 and ≈99.5% coulombic efficiency. The inclusion of fluoroethylene carbonate (FEC) in the electrolyte improves capacity retention over 200 cycles from 13% to 77% at 1000 mA g –1 . This behavior is attributed to the FEC decomposition forming a solid electrolyte interphase (SEI) with higher ion conductivity and robust LiF/Li x PO y F z content, as characterized via XPS Raman spectroscopy.
Antibodies toPlasmodium falciparumandPlasmodium vivaxMerozoite Surface Protein 5 in Indonesia: Species‐Specific and Cross‐Reactive Responses (2008)

PfMSP5 and PvMSP5 were frequently recognized by short-lived, species-specific antibodies. Although infrequent, the cross-reactive MSP5 antibodies indicate that an appropriately formulated vaccine may elicit and/or enhance cross-species recognition, which may be very useful in areas where both parasites are endemic.
Catalytic hydrolysis of a phosphate triester by tetracoordinated zinc complexes (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalytic hydrolysis of a phosphate triester by tetracoordinated zinc complexesSamuel H. Gellman, Russell. Petter, and Ronald. BreslowCite this: J. Am. Chem. Soc. 1986, 108, 9, 2388–2394Publication Date (Print):April 1, 1986Publication History Published online1 May 2002Published inissue 1 April 1986https://pubs.acs.org/doi/10.1021/ja00269a041https://doi.org/10.1021/ja00269a041research-articleACS PublicationsRequest reuse permissionsArticle Views1026Altmetric-Citations183LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Metabolic Differentiation of Diamondback Moth (Plutella xylostella (L.)) Resistance in Cabbage (Brassica oleracea L. ssp. capitata) (2013)

The diamondback moth, Plutella xylostella (L.), is a major pest responsible for destroying cabbage and other Brassica vegetable crops. A diamondback moth-resistant cabbage line was studied by comparing its metabolite profiles with those of a susceptible cabbage. Fourier transform infrared spectroscopy analysis revealed that carbohydrates, aromatic compounds, and amides were the major factors that distinguished the resistant and susceptible genotypes. Gas chromatography-time-of-flight mass spectrometry profiled 46 metabolites, including 19 amino acids, 15 organic acids, 8 sugars, 3 sugar alcohols, and 1 amine in two genotypes and F1 hybrid cabbages. The levels of glycolic acid, quinic acid, inositol, fumaric acid, glyceric acid, trehalose, shikimic acid, and aspartic acid were found to be very significantly different between the resistant and susceptible genotypes with a P value of <0.0001. These results will provide a foundation for further studies on diamondback moth resistance in cabbage breeding and for the development of other herbivore-resistant crops.
Segmented electrode excitation of aluminum nitride contour mode resonators to optimize the device figure of merit (2013)

This paper presents a new electrode configuration for a more efficient excitation of mechanical vibrations in aluminum nitride contour-mode MEMS resonators. We call this technique the segmented electrode excitation. This excitation method results in up to 40% improvement in the figure of merit (FoM) of the resonator, nominally the product of the electromechanical coupling coefficient, k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , and quality factor, Q. The segmented electrode configuration is based on the idea of implementing efficient sampling of the charge developed during vibrations, while reducing the electrode coverage. The reduction in electrode coverage ensures that the resonator exhibits a higher Q as interfacial losses are reduced. The efficient sampling enables attaining a k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> comparable to a conventional metal coverage design.
FLD-based detection of re-compressed speech signals (2010)

Prior works on re-quantization detection were mainly focused on still images and videos, implying that the involved quantization is uniform. In this paper, we examine non-uniform re-quantization, and then investigate the automatic detection of re-compressed speech signals. Based on Fisher Linear Discriminant (FLD), two detection algorithms are described in the time-domain and in the DFT-domain respectively. Comparative experiments indicate that both detection algorithms produce reliable results with AUC values higher than 0.9744 for a set of different experimental setups. In general, time-domain detection performs slightly better than DFT-domain detection. However, the latter is superior in the less dimensionality of input vectors.