gebhart/patrepeval huggingface dataset:
Variational methods for shape reconstruction in computer vision (2003)

This dissertation addresses the problem of inferring the three-dimensional shape and radiance of a scene from a collection of calibrated images taken from different viewpoints. The problem is known as “multi-view stereo” and has been studied extensively in the Computer Vision literature. Most existing multi-view stereo algorithms rely on identification of corresponding points or regions among images. They work effectively only when scenes are Lambertian and have textured radiances, because lack of Lambertianity or absence of texture in the radiance leads to an ill-posed correspondence problem. Targeting scenes with more complex photometric properties, we propose a framework of comparing the images with a model of the scene, which avoids the ill-posed correspondence problem. The model is comprised of a component for shape and a component for radiance. We model the shape as a collection of smooth surfaces and model the radiance based on the underlying reflectance properties. Within this framework, we present two stereo reconstruction algorithms, one for non-Lambertian scenes and the other for Lambertian scenes with smooth radiances. In addressing non-Lambertian scenes, we propose a novel model for the radiance. At the core of the model lies a rank constraint of the radiance tensor field and a discrepancy
Synthesis of a class of complexes containing tungsten-tungsten quadruple bonds (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of a class of complexes containing tungsten-tungsten quadruple bondsPaul R. Sharp and Richard R. SchrockCite this: J. Am. Chem. Soc. 1980, 102, 4, 1430–1431Publication Date (Print):February 1, 1980Publication History Published online1 May 2002Published inissue 1 February 1980https://pubs.acs.org/doi/10.1021/ja00524a041https://doi.org/10.1021/ja00524a041research-articleACS PublicationsRequest reuse permissionsArticle Views672Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
MicroRNA-130b Promotes Tumor Development and Is Associated with Poor Prognosis in (2013)

MicroRNA-130b (miR-130b) is involved in several biologic processes; its role in colorectal tumorigenesis has not been addressed so far. Herein, we demonstrate that miR-130b up-regulation exhibits clinical relevance as it is linked to advanced colorectal cancers (CRCs), poor patients’ prognosis, and molecular features of enhanced epithelial-mesenchymal transition (EMT) and angiogenesis. miR-130b high-expressing cells develop large, dedifferentiated, and vascularized tumors in mouse xenografts, features that are reverted by intratumor injection of a specific antisense RNA. In contrast, injection of the corresponding mimic in mouse xenografts from miR-130b lowexpressing cells increases tumor growth and angiogenic potential while reduces the epithelial hallmarks. These biologic effects are reproduced in human CRC cell lines. We identify peroxisome proliferator–activated receptor γ (PPARγ) as an miR-130b direct target in CRC in vitro and in vivo. Notably, the effects of PPARγ gain- and loss-offunction phenocopy those due to miR-130b down-regulation or up-regulation, respectively, underscoring their biologic relevance. Furthermore, we provide mechanistic evidences that most of the miR-130b–dependent effects are due to PPARγ suppression that in turn deregulates PTEN, E-cadherin, Snail, and vascular endothelial growth factor, key mediators of cell proliferation, EMT, and angiogenesis. Since higher levels of miR-130b are found in advanced tumor stages (III-IV), we propose a novel role of the miR-130b–PPARγ axis in fostering the progression toward more invasive CRCs. Detection of onco-miR-130b and its association with PPARγ may be useful as a prognostic biomarker. Its targeting in vivo should be evaluated as a novel effective therapeutic tool against CRC.
On the Effects of Electric Noise due to the Slits in the PCB Power-Distribution Network with the Differential-Mode Signaling using a Rigorous Modal Analysis Method (2007)

This study investigates the performances of the signaling techniques including differential signals for the power-distribution network(PDN)s with and without the slit, using a rigorous evaluation method 'Modal Analysis', validated by being compared to the FDTD simulation up to 5 GHz.
A Mechanistic Study of Halogen Interaction with Polyamide Reverse-Osmosis Membranes (1985)

Degradation and subsequent failure of polyamide reverse osmosis membranes in response to aqueous chlorine and bromine species has been reported in the literature and observed in the field. The process is clearly pH dependent showing a different pattern of sensitivity related to membrane type. Work described in this study has been directed toward better understanding the nature of halogen attack on membrane polymer. Experiments were conducted with du Pont Aramid B-9 membranes. Halogen exposed samples were examined by infra-red and NMR spectroscopy. Studies with benzanilide, a model compound, are also reported. Experimental evidence shows aromatic ring halogenation to be the dominant process. Membrane failure appears to result from alteration in hydrogen bonding modes within the polymer.
Growth of α-Cr2O3single crystals by mist CVD using ammonium dichromate (2018)

Ammonium dichromate and chromium chloride were examined via thermogravimetric and differential thermal analyses and used to grow α-Cr2O3 via mist chemical vapor deposition. Only the former resulted in noticeable film formation. Using ammonium dichromate, α-Cr2O3 single crystals were grown in a wide growth-temperature range of 300–440 °C. The dependences of the lattice constants a and c on the growth temperature and precursor concentration were explained by combination of (i) lattice reconstruction and (ii) unit-cell volume variation. A maximum growth rate of 10 nm/min; a low (0006) rocking-curve full width at half maximum of 150 arcsec; and low a and c lattice mismatches (with α-Ga2O3) of 0.7 and 1.4%, respectively, were achieved.
A 0.9-V microcontroller for portable applications (1997)

A 0.9-1.6-V, 1-MHz, 8-b microcontroller based on the 68HC08 architecture is presented. In addition to standard digital microcontroller functions, the chip features RAM, ROM, phase-locked loop (PLL) clock synthesis, and liquid crystal displays (LCD) drive capabilities operating from the voltage supply range of a single AA or AAA battery. The design used a library of CMOS microcontroller building blocks, converted into a low-voltage technology using unilateral transistors. The design approach was to optimize the conversion strategy for each functional block and to provide new designs when the conversion was insufficient. The chip exceeded specifications with blocks showing full functionality down to 0.7 V.
Assessing delivery and quantifying efficacy of small interfering ribonucleic acid therapeutics in the skin using a dual-axis confocal microscope (2010)

Transgenic reporter mice and advances in imaging instrumentation are enabling real-time visualization of cellular mechanisms in living subjects and accelerating the development of novel therapies. Innovative confocal microscope designs are improving their utility for microscopic imaging of fluorescent reporters in living animals. We develop dual-axis confocal (DAC) microscopes for such in vivo studies and create mouse models where fluorescent proteins are expressed in the skin for the purpose of advancing skin therapeutics and transdermal delivery tools. Three-dimensional image volumes, through the different skin compartments of the epidermis and dermis, can be acquired in several seconds with the DAC microscope in living mice, and are comparable to histologic analyses of reporter protein expression patterns in skin sections. Intravital imaging with the DAC microscope further enables visualization of green fluorescent protein (GFP) reporter gene expression in the skin over time, and quantification of transdermal delivery of small interfering RNA (siRNA) and therapeutic efficacy. Visualization of transdermal delivery of nucleic acids will play an important role in the development of innovative strategies for treating skin pathologies.
Comparative sequence and structure analysis reveal features of cold adaptation of an enzyme in the thermolysin family (2005)

Knowledge about the structural features underlying cold adaptation is important for designing enzymes of different industrial relevance. Vibriolysin from Antarctic bacterium strain 643 (VAB) is at present the only enzyme of the thermolysin family from an organism that thrive in extremely cold climate. In this study comparative sequence-structure analysis and molecular dynamics (MD) simulations were used to reveal the molecular features of cold adaptation of VAB. Amino acid sequence analysis of 44 thermolysin enzymes showed that VAB compared to the other enzymes has: (1) fewer arginines, (2) a lower Arg/(Lys + Arg) ratio, (3) a lower fraction of large aliphatic side chains, expressed by the (Ile + Leu)/(Ile + Leu + Val) ratio, (4) more methionines, (5) more serines, and (6) more of the thermolabile amino acid asparagine. A model of the catalytic domain of VAB was constructed based on homology with pseudolysin. MD simulations for 3 ns of VAB, pseudolysin, and thermolysin supported the assumption that cold-adapted enzymes have a more flexible three-dimensional (3D) structure than their thermophilic and mesophilic counterparts, especially in some loop regions. The structural analysis indicated that VAB has fewer intramolecular cation-pi electron interactions and fewer hydrogen bonds than its mesophilic (pseudolysin) and thermophilic (thermolysin) counterparts. Lysine is the dominating cationic amino acids involved in salt bridges in VAB, while arginine is dominating in thermolysin and pseudolysin. VAB has a greater volume of inaccessible cavities than pseudolysin and thermolysin. The electrostatic potentials on the surface of the catalytic domain were also more negative for VAB than for thermolysin and pseudolysin. Thus, the MD simulations, the structural patterns, and the amino acid composition of VAB relative to other enzymes of the thermolysin family suggest that VAB possesses the biophysical properties generally following adaptation to cold climate.
Social Power Increases Interoceptive Accuracy (2017)

Building on recent psychological research showing that power increases self-focused attention, we propose that having power increases accuracy in perception of bodily signals, a phenomenon known as interoceptive accuracy. Consistent with our proposition, participants in a high-power experimental condition outperformed those in the control and low-power conditions in the Schandry heartbeat-detection task. We demonstrate that the effect of power on interoceptive accuracy is not explained by participants’ physiological arousal, affective state, or general intention for accuracy. Rather, consistent with our reasoning that experiencing power shifts attentional resources inwards, we show that the effect of power on interoceptive accuracy is dependent on individuals’ chronic tendency to focus on their internal sensations. Specifically, we show that the effect of having power on interoceptive accuracy is stronger (vs. weaker) among individuals with a lower (vs. a higher) chronic tendency to focus on internal sensations. Finally, we demonstrate that individuals’ chronic sense of power also predicts interoceptive accuracy similar to, and independent of, how their situationally induced feeling of power does. We, therefore, provide further support on the relation between power and enhanced perception of bodily signals. Our findings provide initial evidence for the causal connection between social power and interoceptive accuracy and offer a novel perspective – a psychophysiological account- on how power might affect judgments and behavior. We highlight and discuss some of these intriguing possibilities for future research in the general discussion of this article.
Fluorescent risedronate analogue 800CW-pRIS improves tooth extraction-associated abnormal wound healing in zoledronate-treated mice (2022)

Topical pre-treatment with 800CW-RIS in DNV is a promising approach to prevent the complication of abnormal oral wound healing associated with BRONJ while retaining the anti-resorptive benefit of legacy N-BP in appendicular or vertebrate bones.
Contour interaction in fovea and periphery (2000)

It has been known for some time that both foveal and peripheral visual acuity are higher for single letters than for letters in a row. Early work showed that this was due to the destructive interaction of adjacent contours (termed contour interaction). It has been assumed to have a neural basis, and a number of competing explanations have been advanced that implicate either high-level or low-level stages of visual processing. Our previous results for foveal vision suggested a much simpler explanation, one determined primarily by the physics of the stimulus rather than the physiology of the visual system. We show that, under conditions of contour interaction or crowding, the most relevant physical spatial-frequency band of the letter is displaced to higher spatial frequencies and that foveal vision tracks this change in spatial scale. In the periphery, however, beyond 5 degrees, the physical explanation is not sufficient. Here we show that there are genuine physiological lateral spatial interactions, which are due to changes in the spatial scale of analysis.
Uncovering a Latent Ligation Site for Glycopeptide Synthesis (2008)

Serin im Fokus: Ein Konzept zur nativen chemischen Ligation an der Serinposition wird vorgestellt (siehe Bild). Dies gelang durch die Konversion von Methylcystein, das wiederum durch selektive S-Methylierung zugänglich war, mithilfe von CNBr. Mit diesem Verfahren kann eine Konsensussequenz, die allgemein in N-verknüpfte Oligosaccharide eingebaut wird, im Verlauf einer Glycopeptidsynthese als Ligationsstelle genutzt werden. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2008/z801097_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Au and Al Schottky barrier formation on GaAs (100) surfaces prepared by thermal desorption of a protective arsenic coating (1991)

Soft x-ray photoemission spectroscopy has been used to investigate the initial stages of Schottky barrier formation on GaAs (100) surfaces prepared by the thermal desorption of an As cap. This work was motivated by a previous study [Brillson et al., J. Vac. Sci. Technol. B 6, 1263 (1988)] of identically grown and capped samples which reported ‘‘unpinned’’ Schottky barrier formation, with barrier heights falling over a wide range (0.75 eV) of energies. This large energy range is a striking result, as a considerable number of prior studies on both (110) and (100) surfaces have found that all metals will pin in a narrow (0.25 eV) range near midgap. Since Au and Al are the extremes of the larger 0.75 eV span of Schottky barriers, we have studied the deposition of these two metals. We found that the barrier height measurements on the low doped n-type samples used in this work and in the paper referenced above are affected by photovoltaic effects, even at room temperature. These photovoltaic effects cause shifts in the band bending, which are an artifact of the measurement. We also performed measurements on more heavily doped samples, and the photovoltaic effects were removed. In addition, we point out that Au–Ga alloying makes the case of Au potentially misleading. With the photovoltaic effects removed, and the Au–Ga alloying carefully accounted for, we found that the barriers heights for Au and Al differ by only 0.25 eV.
Immunotoxicity of N-butylbenzenesulfonamide: impacts on immune function in adult mice and developmentally exposed rats (2023)

N-butylbenzenesulfonamide (NBBS) is a high-production volume plasticizer that is an emerging contaminant of concern for environmental and human health. To understand the risks and health effects of exposure to NBBS, studies were conducted in adult-exposed mice and developmentally exposed rats to evaluate the potential for NBBS to modulate the immune system. Beginning between 8 and 9 weeks of age, dosed feed containing NBBS at concentrations of 0, 313, 625, 1250, 2500, and 5000 ppm was continuously provided to B6C3F1/N female mice for 28 days. Dosed feed was also continuously provided to time-mated Harlan Sprague Dawley (Sprague Dawley SD) rats at concentrations of 0-, 250-, 500-, and 1000-ppm NBBS from gestation day 6 to postnatal day 28 and in F1 rats until 11-14 weeks of age. Functional assessments of innate, humoral, and cell-mediated immunity were conducted in adult female mice and F1 rats following exposure to NBBS. In female mice, NBBS treatment suppressed the antibody-forming cell (AFC) response to SRBC with small increases in T-cell responses and natural killer (NK)-cell activity. In developmentally exposed rats, NBBS treatment-related immune effects were sex dependent. A positive trend in NK-cell activity occurred in male F1 rats while a negative trend occurred in female F1 rats. The AFC response to SRBC was decreased in female F1 rats but not in male F1 rats. These data provide evidence that oral exposure to NBBS has the potential to produce immunomodulatory effects on both innate and adaptive immune responses, and these effects appear to have some dependence on species, sex, and period of exposure (developmental vs adult).
RNA–Mediated Epigenetic Heredity Requires the Cytosine Methyltransferase Dnmt2 (2013)

RNA-mediated transmission of phenotypes is an important way to explain non-Mendelian heredity. We have previously shown that small non-coding RNAs can induce hereditary epigenetic variations in mice and act as the transgenerational signalling molecules. Two prominent examples for these paramutations include the epigenetic modulation of the Kit gene, resulting in altered fur coloration, and the modulation of the Sox9 gene, resulting in an overgrowth phenotype. We now report that expression of the Dnmt2 RNA methyltransferase is required for the establishment and hereditary maintenance of both paramutations. Our data show that the Kit paramutant phenotype was not transmitted to the progeny of Dnmt2(-/-) mice and that the Sox9 paramutation was also not established in Dnmt2(-/-) embryos. Similarly, RNA from Dnmt2-negative Kit heterozygotes did not induce the paramutant phenotype when microinjected into Dnmt2-deficient fertilized eggs and microinjection of the miR-124 microRNA failed to induce the characteristic giant phenotype. In agreement with an RNA-mediated mechanism of inheritance, no change was observed in the DNA methylation profiles of the Kit locus between the wild-type and paramutant mice. RNA bisulfite sequencing confirmed Dnmt2-dependent tRNA methylation in mouse sperm and also indicated Dnmt2-dependent cytosine methylation in Kit RNA in paramutant embryos. Together, these findings uncover a novel function of Dnmt2 in RNA-mediated epigenetic heredity.
CMOS-compatible multiple wavelength oscillator for on-chip interconnects (2009)

Silicon photonics enables on-chip ultra-high bandwidth optical communications networks which is critical for the future of microelectronics1,2. By encoding information on-chip using multiple wavelength channels through the process of wavelength division multiplexing (WDM), communication bandwidths in excess of 1 Tbit s-1 are possible3. Already several optical components critical to WDM networks have been demonstrated in silicon, however a fully integrated multiple wavelength source capable of driving such a network has not yet been realized. Optical amplification, a necessary component for producing a source, can be achieved in silicon through stimulated Raman scattering4,5, parametric mixing6, and the use of silicon nanocrystals7 or nanopatterned silicon8. Losses in most of these previously demonstrated devices have prevented oscillations in those structures. Raman oscillators have been demonstrated9-11, but the narrow Raman gain window limits operation to a tightly restricted (~ 1 nm) wavelength range and thus is insufficient for WDM. Losses in other previously demonstrated devices have prevented oscillations in those structures. Here we demonstrate the first monolithically integrated CMOS-compatible multiple wavelength source by creating an optical parametric oscillator (OPO) formed by a silicon nitride ring resonator on silicon coupled to an integrated waveguide. The device can generate more than 100 new wavelengths, spaced by a few nm, with operating powers below 50 mW. This source can form the backbone of a fully operational high-bandwidth optical communications network on a microelectronic chip enabling the next generation of multi-core microprocessors.
The Neon Image Processing Language (2010)

There are mixed findings on whether neighbourhood income inequality leads to better self-rated health (SRH) or not. This study considers two hypotheses: individuals living in more unequal neighbourhoods have better SRH and the level of neighbourhood income inequality and its impact on SRH is moderated by household and neighbourhood level income related variables. Data from Waves 8-10 of the UK Household Longitudinal Study for respondents living in England at wave 8 were used. Neighbourhood income inequality was measured using Gini coefficients of household income from the Pay As You Earn and benefits systems for Lower Super Output Areas. Longitudinal ordinal multilevel models predicted self-rated health in 2016-18, 2017-19 and 2019-20 by income inequality and its interaction with household income, neighbourhood median income and neighbourhood deprivation, conditional on individual educational attainment, age, sex, ethnic group, years lived in current residence, region of residence and study wave. There were 24,889 respondents analysed over three waves. SRH was worse for those living in more income equal neighbourhoods. There was no indication that neighbourhood inequality was moderated by household income, neighbourhood median income or neighbourhood deprivation. These findings are in line with the balance of existing evidence and support policy interventions that aim to create mixed communities for the purpose of improving population health.