gebhart/patrepeval huggingface dataset:
The Stress- and Inflammatory Cytokine-induced Ectodomain Shedding of Heparin-binding Epidermal Growth Factor-like Growth Factor Is Mediated by p38 MAPK, Distinct from the 12-O-Tetradecanoylphorbol-13-acetate- and Lysophosphatidic Acid-induced Signaling Cascades (2003)

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a critical growth factor for a number of physiological and pathological processes. HB-EGF is synthesized as a membrane-anchored form (pro-HB-EGF), and pro-HB-EGF is cleaved at the cell surface to yield soluble HB-EGF by a mechanism called "ectodomain shedding." We show here that the ectodomain shedding of pro-HB-EGF in Vero cells is induced by various stress-inducing stimuli, including UV light, osmotic pressure, hyperoxidation, and translation inhibitors. The pro-inflammatory cytokine interleukin-1beta also stimulated the ectodomain shedding of pro-HB-EGF. An inhibitor of p38 MAPK (SB203580) or the expression of a dominant-negative (dn) form of p38 MAPK inhibited the stress-induced ectodomain shedding of pro-HB-EGF, whereas an inhibitor of JNK (SP600125) or the expression of dnJNK1 did not. 12-O-Tetradecanoylphorbol-13-acetate (TPA) and lysophosphatidic acid (LPA) are also potent inducers of pro-HB-EGF shedding in Vero cells. Stress-induced pro-HB-EGF shedding was not inhibited by the inhibitors of TPA- or LPA-induced pro-HB-EGF shedding or by dn forms of molecules involved in the TPA- or LPA-induced pro-HB-EGF shedding pathway. Reciprocally, SB203580 or dnp38 MAPK did not inhibit TPA- or LPA-induced pro-HB-EGF shedding. These results indicate that stress-induced pro-HB-EGF shedding is mediated by p38 MAPK and that the signaling pathway induced by stress is distinct from the TPA- or LPA-induced pro-HB-EGF shedding pathway.
Assessing the thermoelectric properties of CuxO (x = 1 to 2) thin films as a function of composition (2015)

Series of CuxO thin-films in the entire range of compositions 1≤x≤2 were obtained by varying the oxygen flux in an rf-sputter deposition process. Growth windows for three crystalline phases, i.e., the thermodynamically stable cuprous oxide Cu2O and cupric oxide CuO as well as the metastable paramelaconite Cu4O3, were observed. The crystalline phases persist non-stoichiometrically over a wide range of compositions. These flux-range windows are separated by ranges where highly disordered, almost amorphous material is obtained. All samples were analysed with respect to their thermoelectric properties, i.e., Seebeck coefficient, electrical, and thermal conductivity. Clear trends of these transport parameters were found and used to determine the thermoelectric figure of merit ZT. The ZT-values at room temperature are highest for the two thermodynamically stable crystalline phases CuO and Cu2O.
Synthesis of Bifunctional Lipoxin‐Derived Enzyme‐Triggered CO‐Releasing Molecules (LipET‐CORMs) (2023)

Abstract In an attempt to develop new anti‐inflammatory agents which act by co‐release of carbon monoxide (CO) and a specialized pro‐resolving mediator, we designed conjugates of a lipoxin A 4 analogue and an acyloxycyclohexadiene‐Fe(CO) 3 complex as an esterase‐triggered CO‐releasing molecule (ET‐CORM). After adjustment of the protecting group strategy, two of such compounds were successfully prepared by total synthesis (12 steps; 4–5 % overall yield) starting from deoxy‐ d ‐ribose and exploiting a Wittig olefination and an intermolecular Heck reaction as key C−C bond‐forming steps. A crucial late reduction of an aryl‐ketone moiety in the presence of a highly sensitive dienol ester functionality was achieved with BH 3 ‐SMe 2 in the presence of catalytic amounts of NaBH 4 . Both target compounds were dose‐dependently toxic towards cultured human umbilical vein endothelial cells (HUVEC), with LipET‐CORM 1‐A being slightly more toxic. While induction of heme oxygenase 1 (HO‐1) in HUVEC was observed for both compounds, they did not inhibit TNF‐α‐mediated VCAM‐1 expression in these cells. In M2 polarized macrophages HO‐1 expression was more pronounced as compared to M1 polarized macrophages. In both types of macrophages HO‐1 expression was downregulated by lipopolysaccharide, but only in M2 macrophages HO‐1 expression was rescued by LipET‐CORM. 15‐Lipoxygenase (15‐LO) was only expressed in M2 macrophages and was not influenced by LipET‐CORM. Collectively our data demonstrate that LipET‐CORMs induce HO‐1 expression in endothelial cells and M2 polarized macrophages. The role of the intra‐cellular released lipoxin A 4 in resolution of inflammation, however, remains to be assessed.
Benchmarking a Multimodal and Multiview and Interactive Dataset for Human Action Recognition (2016)

Human action recognition is an active research area in both computer vision and machine learning communities. In the past decades, the machine learning problem has evolved from conventional single-view learning problem, to cross-view learning, cross-domain learning and multitask learning, where a large number of algorithms have been proposed in the literature. Despite having large number of action recognition datasets, most of them are designed for a subset of the four learning problems, where the comparisons between algorithms can further limited by variances within datasets, experimental configurations, and other factors. To the best of our knowledge, there exists no dataset that allows concurrent analysis on the four learning problems. In this paper, we introduce a novel multimodal and multiview and interactive (M2I) dataset, which is designed for the evaluation of human action recognition methods under all four scenarios. This dataset consists of 1760 action samples from 22 action categories, including nine person-person interactive actions and 13 person-object interactive actions. We systematically benchmark state-of-the-art approaches on M2I dataset on all four learning problems. Overall, we evaluated 13 approaches with nine popular feature and descriptor combinations. Our comprehensive analysis demonstrates that M2I dataset is challenging due to significant intraclass and view variations, and multiple similar action categories, as well as provides solid foundation for the evaluation of existing state-of-the-art algorithms.
Supplementary Figure 6 from A High Molecular Weight Melanoma-Associated Antigen–Specific Chimeric Antigen Receptor Redirects Lymphocytes to Target Human Melanomas (2023)

Supplementary Figure 6 from A High Molecular Weight Melanoma-Associated Antigen–Specific Chimeric Antigen Receptor Redirects Lymphocytes to Target Human Melanomas
GHT (2002)

Making effective use of the vast amounts of data gathered by large-scale sensor networks will require scalable, self-organizing, and energy-efficient data dissemination algorithms. Previous work has identified data-centric routing as one such method. In an asso-ciated position paper [23], we argue that a companion method, data-centric storage (DCS), is also a useful approach. Under DCS, sensed data are stored at a node determined by the name associated with the sensed data. In this paper, we describe GHT, a Geographic Hash Table system for DCS on sensornets. GHT hashes keys into geographic coordi-nates, and stores a key-value pair at the sensor node geographically nearest the hash of its key. The system replicates stored data lo-cally to ensure persistence when nodes fail. It uses an efficient consistency protocol to ensure that key-value pairs are stored at the appropriate nodes after topological changes. And it distributes load throughout the network using a geographic hierarchy. We evaluate the performance of GHT as a DCS system in simulation against two other dissemination approaches. Our results demonstrate that GHT is the preferable approach for the application workloads predicted in [23], offers high data availability, and scales to large sensornet deployments, even when nodes fail or are mobile.
Final results of a phase II pharmacokinetic/pharmacodynamic (PK/PD) study of combination voreloxin and cytarabine in patients with relapsed or refractory acute myeloid leukemia. (2010)

6526 Background: Voreloxin (VOR), an anticancer quinolone derivative that inhibits topoisomerase II, is active in ovarian cancer and acute myeloid leukemia (AML). Nonclinical studies showed synergistic activity of VOR and cytarabine (ara-C) (Scatena Cancer Chemother Pharmacol 2010). Methods: Phase (ph) Ib results were presented previously (Proc ASCO 2009). Ph II expansions in first relapse (frel) and primary refractory (pref) AML were at 80 mg/m2 VOR/400 mg/m2 ara-C by 24-hr CIV in schedule A (A) and 90 mg/m2 VOR/1 g/m2 ara-C by 2-hr IV infusion in schedule B (B). VOR dosing days 1, 4; ara-C daily ×5. Up to 4 cycles allowed. Response determined by IWG criteria. Blood, urine, and bone marrow aspirate (BMA) collected for PK or PD analysis. Ph II populations pooled and subset analysis of pref/early frel (efrel) outcome performed as safety/efficacy results were comparable in A and B. Results: CR+CRp+CRi (ORR) was 32% (12/37) frel and 25% (8/32) pref; most were CR (17 of 20). Fourteen ph II patients went to transplant (12 responders, 1 partial responder, 1 treatment failure). Preliminary median overall survival (OS) was 7.8 months (mo) (95% CI 4.7-10.2). All-cause mortality was 3% (2/69) at 30 days and 8% (5/63) at 60 days. Activity was similar in patients with efrel (CR1 ≤ 12 mo) and pref (ORR 28%, OS 7.3 mo [95% CI 6-9.9]), a patient group with poor outcomes. Nonhematologic grade ≥ 3 adverse events > 10% at VOR 70–90 mg/m2: aggregated (ag) upper GI mucositis 17%; ag lower GI mucositis 9%; febrile neutropenia 37%; ag sepsis/bacteremia 23%, ag infections 15%, and ag pneumonia 10%; hypokalemia 19%. PK/PD: VOR PK was dose proportional and unaffected by ara-C. DNA damage PD response seen with increased pDNA-PKcs/pCHK2 in BMA of 15/23 patients at ≥ 34 mg/m2 VOR/ara-C. Conclusions: Activity of combination VOR with intermediate dose ara-C is promising, warranting further study in a randomized setting. Safety and activity profile in pref and efrel (CR1 ≤ 12 mo) patients: ORR (28%), 30- and 60-day all-cause mortality (5% average), and OS (7.3 mo) compares favorably with recent data for other AML therapies (Litzow BJH 2009; Giles Blood 2009). Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Sunesis Pharmaceuticals Sunesis Pharmaceuticals Sunesis Pharmaceuticals
ChemInform Abstract: Addition of Phenols to Perfluorovinyl Ethers. Protonation and Halogenation of Carbanionic Intermediates. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Nanoimprint lithography of high-density cobalt dot patterns for fine tuning of dipole interactions (2001)

A trilayer nanoimprint process was used to fabricate high-density Co dot arrays. It is shown that choosing hybrane as the top layer resist gives better dimensional control of the replicated patterns compared to PMMA. By adjusting the etching time in the transfer process the dot sizes could be tailored in a wide range. The fabricated dot arrays with different sizes and period have then been studied by magneto-optic and magnetic-force microscopy measurements. The magnetization reversal was found to occur through vortex nucleation/annihilation. Dipolar interactions were clearly identified both in arrays with constant dot diameter and variable period and in arrays with fixed period and variable dot diameters. In the case of closely packed dots vortex chain structures along the field direction can be formed as a consequence of a nucleation cascade process.
Cardioprotective Effects of Red Raspberries in Obesity‐prone Rats (2016)

The intake of red raspberry fruit is inversely related to cardiac risk factors and cardiovascular disease. In this study, the effect of red raspberry intake was assessed in obesity‐prone, Zucker Fatty rats as a model of cardiometabolic risk. For 8 weeks, rats were fed a higher‐fat diet (45% of kcal) containing 2% (wt/wt) freeze‐dried whole raspberry powder (RSP) or added sugars (CON) to match macronutrient and calorie content. RSP reduced fasting triglycerides and fasting glucose but did not appear to affect fasting insulin, fasting low‐density lipoprotein, or body weight gain. RSP trended but did not significantly reduce systolic blood pressure, but did significantly reduce heart rate relative to time‐matched CON rats. Noteworthy, compared to CON, RSP significantly reduced left ventricular (LV) enlargement and wall thickening as measured by echocardiography, without impacting ejection fraction. LV remodeling is a known risk factor for and precursor to heart failure. Ongoing studies of LV tissue will reveal molecular changes related to inflammation and fibrosis. Red raspberries could be an excellent candidate for dietary management cardiometabolic risk, including risk for Type‐2 diabetes. Also, intake of red raspberries could reduce eventual pathologies like heart failure, which in the US, is the leading diagnosis over the age of 65. Support or Funding Information Acknowledgements: This study was supported by National Processed Raspberry Council grant
Routing, scheduling, timing and intractability (2002)

The management of the various cooperation modes and timing requirements in the case of a large number of tasks poses interesting theoretical problems in massively parallel environments. These systems are in general fully distributed ones, preventing coherent observability. Moreover, their configurations may change dynamically because of failures and/or modifications. Thus no optimal algorithms can be constructed for the effective utilization of the resources available. The influence of the granularity level, cooperation modes and timing requirements are scrutinized in order to identify areas for further research. It is shown that the resource allocation procedure should be partitioned into distinct phases both in time and space.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Alzheimer's Disease: Brain Desmosterol Levels (2013)

Desmosterol is a C27 sterol intermediate in cholesterol synthesis generated during the metabolic pathway that transforms lanosterol into cholesterol. It has become of particular interest in the pathogenesis of Alzheimer's disease (AD) because of the report that the activity of the gene coding for the enzyme DHCR24, which metabolizes desmosterol to cholesterol, is selectively reduced in the affected areas of the brain. Any change in the pattern of C27 sterol intermediates in cholesterol synthesis merits investigation with respect to the pathogenesis of AD, since neurosteroids such as progesterone can modulate the tissue levels. We therefore analyzed the C27 sterol composition using a metabolomics approach that preserves the proportion of the different sterol intermediates. In AD, the proportion of desmosterol was found to be less than that of age-matched controls. The findings do not directly support the focus on Seladin-1, although they could reflect different stages of a slowly progressive disease.
SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells (2017)

SAMHD1 is an intracellular enzyme that specifically degrades deoxynucleoside triphosphates into component nucleoside and inorganic triphosphate. In myeloid-derived dendritic cells and macrophages as well as resting T-cells, SAMHD1 blocks HIV-1 infection through this dNTP triphosphohydrolase activity by reducing the cellular dNTP pool to a level that cannot support productive reverse transcription. We now show that, in addition to this direct effect on virus replication, manipulating cellular SAMHD1 activity can significantly enhance or decrease the anti-HIV-1 efficacy of nucleotide analogue reverse transcription inhibitors presumably as a result of modulating dNTP pools that compete for recruitment by viral polymerases. Further, a variety of other nucleotide-based analogues, not normally considered antiretrovirals, such as the anti-herpes drugs Aciclovir and Ganciclovir and the anti-cancer drug Clofarabine are now revealed as potent anti-HIV-1 agents, under conditions of low dNTPs. This in turn suggests novel uses for nucleotide analogues to inhibit HIV-1 in differentiated cells low in dNTPs.
Classification with Scattering Operators (2010)

A scattering vector is a local descriptor including multiscale and multi-direction co-occurrence information. It is computed with a cascade of wavelet decompositions and complex modulus. This scattering representation is locally translation invariant and linearizes deformations. A supervised classification algorithm is computed with a PCA model selection on scattering vectors. State of the art results are obtained for handwritten digit recognition and texture classification.
Microseismic shearing driven by hydraulic-fracture opening: An interpretation of source-mechanism trends (2015)

Abstract Hydraulic-fracture microseismicity is interpreted for cases in which persistent dip-slip or strike-slip mechanisms exhibit shear planes prevalently aligned close to the principal stress direction. Explaining the preferential alignment in terms of stress changes driven by elevated pore pressure on a Mohr diagram is difficult. Instead, it is proposed that the microseismic shearing is driven primarily by the strain of hydraulic-fracture opening. The interpretation is based on the analog of structures and deformation commonly associated with natural joint growth in layered rock. Specifically, by considering the alternate, horizontal nodal plane as the slip plane for the aligned dip-slip events, one can associate the shearing with a vertical hydraulic fracture stepping over or jogging along bedding planes and generating bedding-plane slip. For the aligned strike-slip events, it is proposed that the critical shearing is generated by breakup of the hydraulic fracture into en echelon fringe fractures near bedding surfaces. In both cases, the shearing represents a tearing mode (mode III) in which the microseismicity highlights the deformation at and near bedding boundaries as the hydraulic fracture rips through or along layer interfaces.
Nuclear COMMD1 Is Associated with Cisplatin Sensitivity in Ovarian Cancer (2016)

Copper metabolism MURR1 domain 1 (COMMD1) protein is a multifunctional protein, and its expression has been correlated with patients' survival in different types of cancer. In vitro studies revealed that COMMD1 plays a role in sensitizing cancer cell lines to cisplatin, however, the mechanism and its role in platinum sensitivity in cancer has yet to be established. We evaluated the role of COMMD1 in cisplatin sensitivity in A2780 ovarian cancer cells and the relation between COMMD1 expression and response to platinum-based therapy in advanced stage high-grade serous ovarian cancer (HGSOC) patients. We found that elevation of nuclear COMMD1 expression sensitized A2780 ovarian cancer cells to cisplatin-mediated cytotoxicity. This was accompanied by a more effective G2/M checkpoint, and decreased protein expression of the DNA repair gene BRCA1, and the apoptosis inhibitor BCL2. Furthermore, COMMD1 expression was immunohistochemically analyzed in two tissue micro-arrays (TMAs), representing a historical cohort and a randomized clinical trial-based cohort of advanced stage HGSOC tumor specimens. Expression of COMMD1 was observed in all ovarian cancer samples, however, specifically nuclear expression of COMMD1 was only observed in a subset of ovarian cancers. In our historical cohort, nuclear COMMD1 expression was associated with an improved response to chemotherapy (OR = 0.167; P = 0.038), although this association could not be confirmed in the second cohort, likely due to sample size. Taken together, these results suggest that nuclear expression of COMMD1 sensitize ovarian cancer to cisplatin, possibly by modulating the G2/M checkpoint and through controlling expression of genes involved in DNA repair and apoptosis.
Quantifying the lifetime circadian rhythm of physical activity: a covariate-dependent functional approach (2014)

Objective measurement of physical activity using wearable devices such as accelerometers may provide tantalizing new insights into the association between activity and health outcomes. Accelerometers can record quasi-continuous activity information for many days and for hundreds of individuals. For example, in the Baltimore Longitudinal Study on Aging physical activity was recorded every minute for [Formula: see text] adults for an average of [Formula: see text] days per adult. An important scientific problem is to separate and quantify the systematic and random circadian patterns of physical activity as functions of time of day, age, and gender. To capture the systematic circadian pattern, we introduce a practical bivariate smoother and two crucial innovations: (i) estimating the smoothing parameter using leave-one-subject-out cross validation to account for within-subject correlation and (ii) introducing fast computational techniques that overcome problems both with the size of the data and with the cross-validation approach to smoothing. The age-dependent random patterns are analyzed by a new functional principal component analysis that incorporates both covariate dependence and multilevel structure. For the analysis, we propose a practical and very fast trivariate spline smoother to estimate covariate-dependent covariances and their spectra. Results reveal several interesting, previously unknown, circadian patterns associated with human aging and gender.
Pancreatic Islet Immunoreactivity to the Reg Protein INGAP (2007)

The Reg-related protein family member INGAP (islet neogenesis-associated protein) is a pleiotropic factor enhancing islet neogenesis, neurite growth, beta-cell protection, and beta-cell function. Using an antibody to the N-termini of INGAP, we have identified that immunoreactivity to INGAP localized to the pancreatic endocrine cells in mouse. INGAP- and insulin-immunoreactive cells are mutually exclusive, with INGAP-immunoreactive cells being preserved after streptozotocin-mediated destruction of beta-cells. Glucagon- and INGAP-immunoreactive cells colocalize, although respective antigen expression occurs in different intracellular locations. These data suggest that INGAP-immunoreactive cells include alpha-cells; however, detection of single INGAP-immunoreactive/glucagon-negative cells indicates that this may not be exclusive. In addition to mouse, detection of islet endocrine cells that were INGAP immunoreactive/glucagon immunoreactive/insulin negative was also observed in islets from human, monkey, and rat. These findings reveal that INGAP and/or related group 3 Reg proteins have a conserved expression in the pancreatic islet.