gebhart/patrepeval huggingface dataset:
Practical characterization of PBGA substrates for broad bandwidth high frequency operation (2002)

Organic laminate substrates for many MCM-L applications are expected to deliver acceptable signal integrity at frequencies approaching 1 GHz. The higher signal transmitting frequencies are required by new integrated circuit (IC) designs that constantly deliver greater functionality. If the system level electrical performance goals are to be met, PBGA (plastic ball grid array) package formats serving as the MCM-L platform must provide low loss, broad bandwidth signal paths between the IC's contained within, and the printed circuit board (PCB). This paper has two objectives. The first is a comparison of two different test methods that evaluate the package level signal parasitics of inductance and capacitance, with a second objective to determine if absorbed moisture will have an obvious effect on the electrical performance of laminate substrates.
An accelerator-based neutron microbeam system for studies of radiation effects (2010)

A novel neutron microbeam is being developed at the Radiological Research Accelerator Facility (RARAF) of Columbia University. The RARAF microbeam facility has been used for studies of radiation bystander effects in mammalian cells for many years. Now a prototype neutron microbeam is being developed that can be used for bystander effect studies. The neutron microbeam design here is based on the existing charged particle microbeam technology at the RARAF. The principle of the neutron microbeam is to use the proton beam with a micrometre-sized diameter impinging on a very thin lithium fluoride target system. From the kinematics of the ⁷Li(p,n)⁷Be reaction near the threshold of 1.881 MeV, the neutron beam is confined within a narrow, forward solid angle. Calculations show that the neutron spot using a target with a 17-µm thick gold backing foil will be <20 µm in diameter for cells attached to a 3.8-µm thick propylene-bottomed cell dish in contact with the target backing. The neutron flux will roughly be 2000 per second based on the current beam setup at the RARAF singleton accelerator. The dose rate will be about 200 mGy min⁻¹. The principle of this neutron microbeam system has been preliminarily tested at the RARAF using a collimated proton beam. The imaging of the neutron beam was performed using novel fluorescent nuclear track detector technology based on Mg-doped luminescent aluminum oxide single crystals and confocal laser scanning fluorescent microscopy.
Percutaneous Mitral Valve Repair with the Edge-to-Edge Technique (2005)

Mitral regurgitation (MR), a common finding, is clinically significant, in part the result of its detrimental effect on left ventricular function. Patients with mild MR can remain asymptomatic for many years. However, moderate to severe MR gradually produces ventricular contractile dysfunction and dilation. Although left ventricular filling pressures are initially maintained in the near-normal range, ultimately left ventricular failure occurs and clinical symptoms develop. Because MR causes volume overload of the left ventricle, a vicious cycle develops. Volume overload leads to remodeling with left ventricular dilation and consequent left ventricular dysfunction. Left ventricular dilation also produces abnormalities of mitral valve support and enlargement of the mitral annulus. These changes lead to progressive worsening of MR (1).
Setting 6G Architecture in Motion – the Hexa-X approach (2022)

The most recent cellular generation, 5G, is being deployed on a large scale globally. The capabilities of 5G surpass all previous generations of cellular networks and support many new services compared to 4G. Despite this, at the same time, preparations for 6G have begun since user demands and technical development continuously push the boundaries of what is possible. Demands come not only from users. Also, society sets requirements, e.g., sustainability, coverage, and privacy. To support the necessary features in the network needed to meet the requirements, a new generation of the architecture is needed; one based on the most forward-looking design principles together with trends in networks, use cases, and whatnot. To show that the proposed new features will allow the future network to meet the set requirements, key performance indicators (KPIs) have to be defined. In this paper, we present six of the KPIs that the European 6G flagship project Hexa-X has identified as the fundamental ones to measure the most important aspects of a new 6G architecture.
In vivo monitoring of the corneal collagen cross-linking using supersonic shear wave imaging: feasibility study on porcine corneas (2012)

International audience
Is it what you see, or how you say it? Spatial bias in young and aged subjects (2008)

Healthy subjects demonstrate leftward bias on visual-spatial tasks. However, young controls may also be left-biased when drawing communicatively, depicting the subject of a sentence leftward on a page relative to the sentence object, that is, a spatial-syntactic, implicit task. A leftward visual-spatial bias may decrease with aging, as right-hemisphere, dorsal, visual-spatial activation may be reduced in elderly subjects performing these tasks. We compared horizontal and radial (near-far) visual spatial bias, and spatial-syntactic bias, in healthy young and aged participants. Both horizontal and radial visual-spatial bias were smaller in aged participants when explicitly, but not implicitly assessed. Mean implicit far bias was greater in aged subjects, although this varied by task. We observed less implicit, spatial-syntactic left bias in aged than young participants. These results may be consistent with relatively less dominance of right hemisphere, dorsal spatial systems with aging.
Figure S4 from HSP90 Inhibitor–SN-38 Conjugate Strategy for Targeted Delivery of Topoisomerase I Inhibitor to Tumors (2023)

&lt;p&gt;γ-H2AX expression analysis in MDA-MB-231 xenografts following STA-12-8663 treatment.&lt;/p&gt;
Comparing dielectric properties of binary composite structures obtained with different calculation tools and methods (2002)

AC dielectric properties of 2D composite structures obtained from numerical simulations are presented. We specially emphasise the accuracy and applicability of different computational tools and methods for modelling of polarisation phenomena in binary mixtures. It is observed that even for the simplest case of a two-layer dielectric mixture, the calculated frequency dependencies of the real and imaginary parts of the average complex permittivity can deviate from the analytical solution. Considering several periodic structures indicate that AC properties are different, dependent on the tool or method used. Therefore, we want to draw attention to the validity of results.
New Synthesis of Poly(Phenylenesulfide)S Through an Electron Transfer (1990)

Abstract Poly(p-phenylenesulfide) (PPS) is efficiently and conveniently produced by a cationic and oxidative polymerization. Diphenyldisulfide is polymerized to PPS through one electron transfer at room temperature. The polymer is isolated as a white powder whose 1,4-structure is confirmed by IR. Phenylbis(phenylthio)sulfonium ion acts as an active species which is formed by oxidation of the S-S bond of diphenyldisulfide, and electrophilically substitutes on the phenyl ring. This polymerization is applicable to the polymerization of alkyl-substituted diphenyldisulfides to give PPSs, such as poly(2-methylphenylenesulfide) and poly(3,5-dimethylphenylene-sulfide).
A Protocol for Visual Cues in Collaborative Augmented Reality Applications (2012)

Inspection and maintenance of complex hardware equipment can have an elevated cost, due to the sophisticated training required for the technicians responsible for those tasks. The use of collaborative Augmented Reality can solve, or at least reduce, the cost of these activities. This paper proposes a protocol for the transmission of visual cues, represented by Augmented Reality elements, in collaborative applications. The protocol focuses on a client-server communication, where the client has the role to remotely supervise the activities, possibly sending interest points or instruction to the server. A prototype application was developed in order to demonstrate the advantages of a real application usage.
Demo (2015)

Recent technological advances have allowed the development of miniaturized sensors and the emergence of a wide range of connected objects. Whether it's smartphones or in the broader sense wearables, the diversity of these devices and their accessibility opens up new fields for applications in the computer sciences [2, 3]. Smartwatches, which are experiencing a boom on the market, will be integral to the research that will shape the Internet in the years to come, namely big data, sensing systems and human behavior. Our demonstration falls within this context and aims to demonstrate the potential of these emerging technologies to respond to problems and to way of thinking introduced by industry and the scientific community, which are generally limited to smartphone sensing frameworks [1]. Further, we plan to present our research platform, SWIPE, which is dedicated to collecting, studying and learning about human dynamics by means of an ecosystem of wearables. A short presentation video is available online at http://swipe.sfaye.com/mobisys15/.
Estimating the Process Zone Length of Fracture Tests (2016)

This paper provides closed-form expressions for theprocess zone lengths and load-displacement responses of cohesive zone modeling,for the popular mode Idou- ble cantileverbeam (DCB) test and the mode II end notched flexure (ENF) testofcom- posite materials. By incorporating traction-separation lawsthat consist of onlyone quasi-brittle softening segment,the problems are formulated and analytically solved for homogenous materialor mid-plane symmetric laminates within the framework of classical laminationtheory(CLT).Th eexpressions indicate that the process zone length isa system parameter that is influenced by themodemixity,the material and interfacial fracture properties as well as the specimen geometry,including the thick- ness and the crack length.Based on the parametric studies and the comparison against finite element(FE)simulations,suggestions for estimating the process zone length are provided.
Clinical characterization of patients with SDHC epimutation in gastrointestinal stromal tumors. (2019)

11033 Background: Gastrointestinal Stromal Tumors are the most common malignancy in the GI tract. While the vast majority exhibit somatic mutations in KIT and PDGFRA, approximately 15% of GIST patients do not have this feature. This group of KIT and PDGFRA “wildtype” GISTs have in common a negative expression of SDHB when interrogated by immunohistochemistry. Succinate dehydrogenase (SDH) is a conserved enzyme that plays a critical role in cellular metabolism and energy production. A loss in SDH function is a mechanism observed in several types of cancers, and germline SDH mutations are considered a tumor predisposition syndrome. This group has reported that SDH-deficient gastrointestinal stromal tumors often harbor germline mutations in the SDH subunit genes (SDHA, SDHB, SDHC, and SDHD, termed SDHx). There is, however, a defined group that shows lack of SDH expression in the absence of mutation. Methods: We performed targeted exome sequencing on GIST patients’ tumor samples from the NIH GIST clinic and identified 25 SDHx-WT cases. Genome-wide DNA methylation and expression profiling showed SDHC promoter-specific CpG island hypermethylation and gene silencing in these 25 SDHx-WT, SDH deficient GISTs. Results: Clinical characterization of this cohort revealed that 24 of 25 SDHC-epimutant GISTs occurred in female patients, with a median age of 12 upon diagnosis. The median tumor size of this cohort of patients was 4.0 cm. Of the 16 patients from whom we were able to obtain complete pathology data, 15 showed epithelioid or mixed-epithelioid tumor morphology. All of them showed negative immunohistochemical staining for SDHB. 15 of 16 patients had multifocal tumors, which is a common finding in this population. Conclusions: The profiling of this cohort provides further insights into the natural history and pathogenesis of SDHC-epimutant GIST tumors.
Deconfigurable microprocessor architectures for silicon debug acceleration (2013)

The share of silicon debug in the overall microprocessor chips development cycle is rapidly expanding due to the ever growing design complexity and the limited efficiency of pre-silicon validation methods. Massive application of short random test programs on the prototype microprocessor chips is one of the most effective parts of silicon debug. However, a major bottleneck and source of "noise" in this phase is that large numbers of random test programs fail due to the same or similar design bugs. This redundant behavior adds long delays in the debug flow since each failing random program must be separately examined, although it does not usually bring new debug information. The development of effective techniques that detect dominant modes of failure among random programs and triage them into common categories eliminate redundant debug sessions and significantly boost silicon debug.
$\mathcal{L}_2$ and $\mathcal{L}_{\infty}$ Stability Analysis of Heterogeneous Traffic With Application to Parameter Optimization for the Control of Automated Vehicles (2018)

The presence of (partially) automated vehicles on the roads presents an opportunity to compensate the unstable behavior of conventional vehicles. Vehicles subject to perturbations should: 1) recover their equilibrium speed and 2) react not to propagate but absorb perturbations. In this paper, we start with considering vehicle systems consisting of heterogeneous vehicles updating their dynamics according to realistic behavioral car-following models. Definitions of all types of stability that are of interest in the vehicle system, namely, input-output stability, scalability, weak and strict string stability, are introduced based on recent studies. Then, frequency domain linear stability analyses are conducted after linearization of the modeled system of vehicles, leading to conditions for input-output stability, strict and weak string stability over the behavioral parameters of the system, for finite and infinite systems of homogeneous and heterogeneous vehicles. This provides a solid basis that was missing for car-following model-based control design in mixed traffic systems where only a proportion of vehicles can be controlled. After visualization of the theoretical results in simulation, we formulate an optimization strategy with linear matrix inequality constraints to tune the behavioral parameters of the automated vehicles in order to maximize the L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">∞</sub> string stability of the mixed traffic flow while considering the comfort of automated driving. The optimization strategy systematically leads to increased traffic flow stability. We show that very few automated vehicles are required to prevent the propagation of realistic disturbances.
Modular Syntheses of Isoxazoloazepinones and Pyrazoloazepinones. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Dynamics-based peptide-MHC binding optimization by a convolutional variational autoencoder: a use-case model for CASTELO (2020)

An unsolved challenge in the development of antigen specific immunotherapies is determining the optimal antigens to target. Comprehension of antigen-MHC binding is paramount towards achieving this goal. Here, we present CASTELO, a combined machine learning-molecular dynamics (ML-MD) approach to design novel antigens of increased MHC binding affinity for a Type 1 diabetes (T1D)-implicated system. We build upon a small molecule lead optimization algorithm by training a convolutional variational autoencoder (CVAE) on MD trajectories of 48 different systems across 4 antigens and 4 HLA serotypes. We develop several new machine learning metrics including a structure-based anchor residue classification model as well as cluster comparison scores. ML-MD predictions agree well with experimental binding results and free energy perturbation-predicted binding affinities. Moreover, ML-MD metrics are independent of traditional MD stability metrics such as contact area and RMSF, which do not reflect binding affinity data. Our work supports the role of structure-based deep learning techniques in antigen specific immunotherapy design.
MoDIR: Motion-Compensated Training for Deep Image Reconstruction without Ground Truth (2021)

Deep neural networks for medical image reconstruction are traditionally trained using high-quality ground-truth images as training targets. Recent work onNoise2Noise (N2N) has shown the potential of using multiple noisy measurements of the same object as an alternative to having a ground truth. However, existing N2N-based methods cannot exploit information from various motion states, limiting their ability to learn on moving objects. This paper addresses this issue by proposing a novel motion-compensated deep image reconstruction (MoDIR) method that can use information from several unregistered and noisy measurements for training. MoDIR deals with object motion by including a deep registration module jointly trained with the deep reconstruction network without any ground-truth supervision. We validate MoDIR on both simulated and experimentally collected magnetic resonance imaging (MRI) data and show that it significantly improves imaging quality.
Electrocatalytic carbon dioxide reduction - a mechanistic study (2013)

&lt;p&gt;This thesis presents new insights into the reduction of carbon dioxide to methane and ethylene on copper electrodes. This electrochemical process has great potential for the storage of surplus renewable electrical energy in the form of hydrocarbons. The research described in this thesis focuses on the molecular reaction mechanism, to identify key intermediates that determine the product selectivity.&lt;br /&gt;&lt;/p&gt;
Dip-Pen Nanolithography-Generated Patterns Used as Gold Etch Resists: A Comparison Study of 16-Mercaptohexadecanioc Acid and 1-Octadecanethiol (2009)

The etch resist ability of dip-pen nanolithography (DPN)-generated dot patterns of different alkanethiols on Au was systematically studied. After 16-mercaptohexadecanioc acid (MHA) and 1-octadecanethiol (ODT) dots with different diameters were patterned on a Au substrate by DPN, the substrate was etched in a feri-/ferrocyanide solution. Tapping mode AFM (TMAFM) was used to monitor the morphology change of the patterned dots during the wet chemical etching. The diameter and height of MHA and ODT dots at different etch time were measured by TMAFM. The resist ability of the patterned MHA and ODT SAMs on Au was compared. The result shows that the MHA patterns have better etch resist ability than do ODT patterns.
Polarization-diversity In-line Phase Sensitive Amplifier for Simultaneous Amplification of Fiber-transmitted WDM PDM-16QAM Signals (2018)

We developed in-line PSA for the simultaneous amplification of wavelength-multiplexed and polarization-multiplexed QAM signals. We achieved >20-dB gain and a 12-nm bandwidth for 16-channel PDM-16QAM signals with an inherent PSA characteristic of a 5.1-dB SNR advantage.
350: Characterization of the MTOR Pathway in Renal Cell Carcinoma and its Use in Predicting Patient Selection for Agents Targeting this Pathway (2005)

You have accessJournal of UrologyVideo Session, Sunday, May 22, 2005 10:00 am - 12:00 pm1 Apr 2005350: Characterization of the MTOR Pathway in Renal Cell Carcinoma and its Use in Predicting Patient Selection for Agents Targeting this Pathway Allan J. Pantuck, David B. Seligson, Hong Wu, George Thomas, Timothy O’Toole, Gary Dukart, Jay Gibbons, Arie S. Belldegrun, and Robert A. Figlin Allan J. PantuckAllan J. Pantuck More articles by this author , David B. SeligsonDavid B. Seligson More articles by this author , Hong WuHong Wu More articles by this author , George ThomasGeorge Thomas More articles by this author , Timothy O’TooleTimothy O’Toole More articles by this author , Gary DukartGary Dukart More articles by this author , Jay GibbonsJay Gibbons More articles by this author , Arie S. BelldegrunArie S. Belldegrun More articles by this author , and Robert A. FiglinRobert A. Figlin More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)34603-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "350: Characterization of the MTOR Pathway in Renal Cell Carcinoma and its Use in Predicting Patient Selection for Agents Targeting this Pathway." The Journal of Urology, 173(4S), p. 96 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 96 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Allan J. Pantuck More articles by this author David B. Seligson More articles by this author Hong Wu More articles by this author George Thomas More articles by this author Timothy O’Toole More articles by this author Gary Dukart More articles by this author Jay Gibbons More articles by this author Arie S. Belldegrun More articles by this author Robert A. Figlin More articles by this author Expand All Advertisement PDF downloadLoading ...
Potent excitation of inspiratory frequency by P2Y 1 receptor activation in the preBotzinger complex (PBC) (2007)

Recent data indicate that ATP is released from the ventral respiratory column (VRC) in response to hypoxia where it acts via P2 receptors (Rs) to partially offset hypoxia‐induced reductions in inspiratory frequency (f). This study used rhythmically‐active medullary slices from neonatal rat to: map the VRC to identify the site of maximum ATP sensitivity; identify the P2R subtype(s) mediating the f effects of ATP, and; explore the cellular mechanisms underlying the effects of ATP on f. Microinjections of ATP in the VRC revealed a ‘hotspot’ where ATP evoked a 2.2±0.1 fold increase in f. The hotspot was identified as the PBC based on histology, overlap of labeled injection sites with NK1R immunolabeling and potentiation or inhibition of f at the same site by Substance P or DAMGO respectively. Whole‐cell recording revealed that ATP evoked inward currents in &gt;90% of PBC respiratory neurons, including a P2Y 1 R antagonist‐sensitive current in putative voltage‐dependent pacemaker neurons. Non‐respiratory PBC neurons were also ATP‐sensitive. In summary, the presence of P2Y 1 Rs in the PBC, the relative potency of P2R agonists, and the block of the ATP‐evoked f response and whole‐cell currents in respiratory PBC neurons by MRS2179, suggest that ATP acts via P2Y 1 Rs in the PBC to stimulate rhythm.
Multimodality imaging of reporter gene expression using a novel fusion vector in living cells and animals (2023)

Novel double and triple fusion reporter gene constructs harboring distinct imagable reporter genes are provided, as well as applications for the use of such double and triple fusion constructs in living cells and in living animals using distinct imaging technologies.