gebhart/patrepeval huggingface dataset:
In-vivo evaluation of human recombinant Co-arginase against A375 melanoma xenografts (2014)

Metastatic melanoma is a deadly form of cancer with few therapeutic options and the cause of more than 9480 deaths annually in the USA alone. Novel treatment options for this disease are urgently needed. Here we test the efficacy of a novel melanoma drug, the human recombinant Co-arginase (CoArgIPEG), against an aggressive A375 melanoma mouse model. CoArgIPEG is a modification of the naturally occurring human enzyme with improved stability, catalytic activity, and potentially lower immunogenicity compared with current amino acid-depleting drugs. Marked tumor growth reductions (mean P=0.0057) with apoptosis induction and proliferation inhibition are noted with CoArgIPEG treatment, both in the presence and in the absence of supplemental citrulline. Further, improved therapeutic efficacy has been noted against A375 xenografts relative to the naturally occurring human recombinant arginase enzyme at lower doses of CoArgIPEG. Unfortunately, after 1 month, half of the relapsing tumors showed argininosuccinate synthase induction, which correlated with Ser62-phosphorylated cMyc. Although argininosuccinate synthase induction could not be induced in vitro, a drug targeting pathway previously demonstrated to be associated with Ser62 cMyc phosphorylation - U0126 - in combination with CoArgIPEG demonstrated an in-vitro synergistic response (combination indices 0.13±0.10 and 0.14±0.10 with or without citrulline, respectively). Overall, favorable efficacy and potential synergy with other antimelanoma drugs support CoArgIPEG as a potent, novel cancer therapeutic.
Pathophysiology of Priapism: Dysregulatory Erection Physiology Thesis. (2003)

This exercise suggested that, while priapism is commonly defined in terms of adverse mechanical contexts affecting penile circulation, it may also be viewed at least in some situations as an unbalanced erectile response involving derangements in possibly diverse systems of regulatory control. An integrative scientific approach that encompasses tissular, cellular and molecular levels of investigation may allow further understanding of the pathophysiology of the disorder. Ongoing elucidation of this pathophysiology can be expected to promote the development of new priapism therapies.
Xipho: extending tropos to engineer context-aware personal agents (2014)

We introduce Xipho, an agent-oriented methodology for engineering context-aware personal agents (CPAs). Xipho extends Tropos to support CPA development. Xipho's steps span a CPA's requirements acquisition, design, and implementation. Importantly, we treat context as a cognitive notion and systematically relate it to other cognitive notions such as goals and plans. Xipho incorporates reusable components in a CPA's design and implementation to simplify the development process. We evaluate Xipho empirically, finding that Xipho reduces development time and effort, and improves the comprehensibility of CPA designs.
PIVKA-II: A biomarker for diagnosing and monitoring patients with pancreatic adenocarcinoma (2021)

These data are the first showing a decreased PIVKA-II serum levels after surgery in PDAC patients and reporting PIVKA-II expression in PDAC tissue. Further studies are needed to confirm these findings and to determine PIVKA-II usefulness in diagnosing and monitoring PDAC patients.
Rhodium-Catalyzed Asymmetric Conjugate Additions of Boronic Acids to Enones Using DIPHONANE:  A Novel Chiral Bisphosphine Ligand (2005)

[reaction: see text] The synthesis of a novel enantiopure C2-symmetric bisphosphine, DIPHONANE, was accomplished starting from 2,5-norbornadione, utilizing (R,R)- and/or (S,S)-(2,3-O-di[(phenylamino)carbonyl]tartaric acid for the resolution of an intermediate phosphineoxide. The application of this ligand in the rhodium-catalyzed asymmetric conjugate addition of boronic acids to cyclic enones provides the 1,4-addition products in good yields (69-98%) and high ee's (78-95% ee). A byproduct arising from a consecutive 1,4-addition and 1,2-addition was also observed.
Heat transfer modelling of toroidal inductors: Effect of orientations (2002)

Experimental studies of free and mixed convection heat transfer from inductor toroids were conducted to determine the effects of the Reynolds and Rayleigh numbers on the area averaged Nusselt number. The experimental program range was conducted in the Reynolds number range 4000/spl les/Re/spl les/13000 and 3/spl times/10/sup 6//spl les/Ra/spl les/7/spl times/10/sup 6/ for the Rayleigh number. Moreover, an appropriate scale for presentation of the free and forced convection phenomena was proposed. In addition, general models were proposed for natural and mixed convection from the inductor toroids in different orientations. The agreement between the models and the experimental data was very good. Finally, the general models were proposed for an inductor with mounting base in free and mixed convection.
The Hemagglutinin of West Nile Virus: Recovery, Properties, and Antigenic Relationships (1954)

Summary A specific hemagglutinin for chick erythrocytes was demonstrated in both unbuffered saline and pH 9 buffered saline extracts of the brain of 3 to 4 week old mice infected with the original (Uganda) strain of West Nile fever virus. In the unbuffered saline extracts (pH 7.1) much of the hemagglutinin was in large aggregates which sedimented at 13,000 rpm, while no such aggregates were present in the alkaline extracts (pH 8.1). Freshly prepared, 13,000 rpm supernates of the alkaline extracts produced hemagglutination between pH 6.7 and 7.5 or 8.0, but maximum titers (as high as 20,480) without zones of absent or poor agglutination in the lower dilutions were obtained at pH 7.1–7.3. After such preparations were stored at 4 C for 4 to 50 days the pH range shifted to the acid side with maximum titers at pH 6.7–6.9. The hemagglutinin in alkaline extracts was not destroyed by repeated freezing and thawing and could be maintained without loss of potency at -70 C. To obtain the maximum titers it was necessary to mix the hemagglutinin with the red cells at 20 to 25 C and to permit sedimentation to occur at 4 C. With certain unbuffered saline extracts no reaction at all occurred when the reagents were at 4 C at the time of mixing, or if sedimentation occurred at 25 C. The reaction between the hemagglutinin and red cells is of the equilibrium type. Hemagglutination can be reversed by repeated resuspensions of the cells, because the uncombined hemagglutinin is unstable at the pH that is optimum for reaction. No receptor-destroying enzyme is involved because the addition of fresh hemagglutinin causes reagglutination of such cells. When 3 other strains of West Nile virus (Egypt 19, 21, and 101) were tested no zone phenomena were encountered and fresh preparations yielded maximum titers at pH 6.7–6.9. Sedimentation at 4 C was needed to obtain maximum titers with strains 19 and 21 but not with 101. All 4 strains yielded identical hemagglutination-inhibition titers with specific antisera. The normal inhibitor present in human and animal sera was best eliminated by precipitating the specific antibody with acetone. Cancer patients experimentally infected with West Nile virus developed high titers of hemagglutination-inhibition antibody for the West Nile hemagglutinins and somewhat lower titers for the St. Louis and Japanese B virus hemagglutinins. Human beings naturally infected with the viruses of St. Louis or Japanese B encephalitis also developed hemagglutination-inhibition antibodies for all 3 viruses but the homologous titers were invariably higher. Hyperimmune rabbit sera for the 3 viruses showed much more extensive crossing by the hemagglutination-inhibition than by the neutralization tests. Hemagglutination-inhibition tests with West Nile, St. Louis and Japanese B hemagglutinins on “normal” Egyptian human sera gave positive results indicative of unrecognized infection only with West Nile virus.
Rapid Low-Cost Prototyping of Terahertz Metallic Metasurfaces (2021)

We present a very simple, rapid and low-cost prototyping technique to fabricate metallic 2D patterns for the terahertz range. We demonstrate arrays of split-ring resonators and wire-grid polarizers.
Detection of Transforming Genes from Radiation Transformed Human Epidermal Keratinocytes by a Tumorigenicity Assay (1991)

Carcinogenic action of ionizing radiation in humans has been well recognized from epidemiological data. There have been, however, very few studies on radiation-induced neoplastic transformation of human cells, particularly, those of epithelial origin, in culture. Recently, we have developed an in vitro human keratinocyte multistep model suitable for the study of human epithelial cell carcinogenesis (1). This was developed following an infection of primary human epidermal keratinocytes with Ad12-SV40 virus leading to the acquisition of an indefinite lifespan in culture, but not the development of malignant phenotype. These immortalized human keratinocytes (RHEK-1) when treated subsequently with either Kirsten murine sarcoma virus (Ki-MSV) (1) or chemical carcinogens, (2) led to the induction of morphological alterations and the development of a malignancy. The availability of this human keratinocyte system led us to determine the potential of X-rays as a carcinogenic agent in human epithelial cells and to characterize the molecular events involved in the development of a radiation-induced malignancy.
Ionospheric Correction Using Tomography (1997)

The most demanding application of wide area di#erential corrections to GPS is vertical positioning of aircraft on precision approach. Here the Wide Area Augmentation System #WAAS# combines accuracy requirements on the order of ones of meters with safety of life integrity requirements which specify that any vertical position errors greater than the Vertical Protection Limit be enunciated to the #ight crew within six seconds. The ionosphere is the foremost impediment to satisfying these requirements. Stanford,as a member of the National Satellite Test Bed #NSTB#, is developing techniques for estimating the ionosphere in real-time. Previous research has established a connection between ionospheric error and vertical positioning error within the framework of modal decomposition. Ionospheric tomographyisa natural extension of modal decomposition to the estimation of the ionosphere&amp;apos;s three-dimensional electron density. We present a tomographic estimation algorithm and its implementation o...
<title>Operational issues for passive millimeter-wave imaging systems</title> (1997)

Passive millimeter wave (mm-wave) imaging systems have attracted an increasing interest over the past years due to their superior poor weather performance compared with visible and infrared systems. In the UK the Defence Evaluation and Research Agency Malvern developed its first mm-wave radiometers in the late 1950s. These systems were bulky and had poor spatial resolution and low thermal sensitivity, but the considerable advances in semiconductor solid state devices have allowed the size and weight of imagers to be reduced. Advantage can also be taken of sophisticated on-line signal processing and of complex theoretical modeling and analysis. This paper examines the merits of the different operating frequencies in terms of atmospheric transmission vs. resolution and also discusses issues such as image processing. High quality images are presented to demonstrate the potential of this emerging technology.
Real‐time observation of transient focal ischemia and hyperemia in cat brain (1992)

Gradient-recalled echo-planar (T2*-weighted) imaging was used to noninvasively monitor regional blood oxygenation state changes in real time during transient episodes of focal ischemia in cat brain. Varying ischemic intervals (12 s to 30 min) were caused by middle cerebral artery occlusion. A rapid signal drop was noted upon occlusion, due to deoxygenation of static blood in the ischemic tissues. Upon successful reperfusion, the signal intensity recovered immediately and increased above (overshot) the baseline level before slowly returning to normal. The "overshoot" response was strongly dependent on the duration of the ischemic interval and is thought to reflect reactive hyperemia.
Supplementary Figure and Figure Legends from CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib (2023)

&lt;p&gt;This file contains the supplementary figures and figure legends. Figure S1: CHK1 overexpression and LY2606368 targeting efficacy in SCLC. Figure S2:Combinatorial effect of LY2606368 and cisplatin. Figure S3: Anti-tumor efficacy of LY2606368. Figure S4: Effect of LY2606368 in platinum-resistant SCLC models. Figure S5: Combinatorial effect of LY2606368 and olaparib. Figure S6 and S7: Proteomic biomarkers of LY2606368 response. Figure S8: MYC expression predicts sensitivity to LY2606368.&lt;/p&gt;
Deficiency of IL-5 receptor alpha-chain selectively influences the development of the common mucosal immune system independent IgA-producing B-1 cell in mucosa-associated tissues. (1999)

Deletion of IL-5R alpha-chain (IL-5R alpha-/-) selectively influenced the mucosal IgA responses in vivo. While levels of IgA in mucosal secretions were more reduced in IL-5R alpha-/- mice than in wild-type mice, the levels of IgA in serum were not changed. The frequency of IgA-producing cells was reduced in mucosal effector sites (e.g., intestinal lamina propria and nasal passage), but not in inductive sites such as Payer's patches and nasal-associated lymphoreticular tissues in IL-5R alpha-/- mice. IgA-committed (surface IgA+; sIgA+) B-1 cells mainly resided in mucosal effector tissues, while conventional sIgA+ B (B-2) cells formed in mucosal inductive sites of wild-type mice. In contrast, in the effector tissue of IL-5R alpha-/- mice, sIgA+ B-1 cells, but not sIgA+ B-2 cells in the inductive site, were significantly reduced. IL-5R alpha was more expressed on sIgA+ B-1 cells than was IL-6R, while both IL-5R alpha and IL-6R were expressed on sIgA+ B-2 cells in wild-type mice. sIgA+ B-1 cells produced high levels of IgA with rIL-5 rather than of rIL-6 in vitro. Taken together, the findings suggest that the IL-5/IL-5R signaling pathway is critically important for the development of common mucosal immune system independent sIgA+ B-1 cell in mucosal effector tissues in vivo.
Impact of Antenna Array Geometry on MIMO Channel Eigenvalues (2006)

Spatial correlation properties of MIMO channel highly depend on the propagation environment and the antenna array geometry. In this paper the impact of different antenna array geometries on MIMO channel eigenvalues is investigated in realistic microcellular propagation environment under different scenarios. Four different antenna array geometries are considered, namely, uniform linear array, uniform circular array, uniform rectangular array and uniform cubic array. All the considered geometries have same number of elements and fixed inter-element spacing. The uniform linear array geometry shows superiority to the other considered geometries.
Suppressed baroreflex peripheral arc overwhelms augmented neural arc and incapacitates baroreflex function in rats with pulmonary arterial hypertension (2019)

Sympathoexcitation has been documented in patients with established pulmonary arterial hypertension (PAH). Although the arterial baroreflex is the main negative feedback regulator of sympathetic nerve activity (SNA), the way in which PAH impacts baroreflex function remains poorly understood. In this study, we conducted baroreflex open-loop analysis in a rat model of PAH. Sprague-Dawley rats were injected with monocrotaline (MCT) s.c. to induce PAH (60 mg kg<sup>-1</sup> ; n = 11) or saline as a control group (CTL; n = 8). At 3.5 weeks after MCT injection, bilateral carotid sinuses were isolated, and intrasinus pressure (CSP) was controlled while SNA at the coeliac ganglia and arterial pressure (AP) were recorded. To examine the static baroreflex function, CSP was increased stepwise while steady-state AP (total arc) and SNA (neural arc) responses to CSP and the AP response to SNA (peripheral arc) were measured. Monocrotaline significantly decreased the static gain of the baroreflex total arc at the operating AP compared with CTL (-0.80 ± 0.31 versus -0.22 ± 0.22, P < 0.05). Given that MCT markedly increased plasma noradrenaline, an index of SNA, by approximately 3.6-fold compared with CTL, calibrating SNA by plasma noradrenaline revealed that MCT shifted the neural arc to a higher SNA level and shifted the peripheral arc downwards. Monocrotaline also decreased the dynamic gain of the baroreflex total arc (-0.79 ± 0.16 versus -0.35 ± 0.17, P < 0.05), while the corner frequencies that reflect the speed of the baroreflex remained unchanged (0.06 ± 0.02 versus 0.08 ± 0.02 Hz, n.s.). In rats with MCT-induced PAH, the suppressed baroreflex peripheral arc overwhelms the augmented neural arc and, in turn, attenuates the gain of the total arc, which determines the pressure-stabilizing capacity of the baroreflex.
Predicting the Effect of Tire Tread Pattern Design on Thick Film Wet Traction (1977)

Abstract An analytical tool is presented for the prediction of the effects of changes in tread pattern design on thick film wet traction performance. Results are reported for studies in which the analysis, implemented on a digital computer, was used to determine the effect of different tread geometry features, among these being the number, width, and lateral spacing of longitudinal grooves and the angle of zigzags in longitudinal grooves, on thick film wet traction. These results are shown to be in good agreement with experimental data appearing in the literature and are used to formulate guidelines for tread groove network design practice.
A practical approach to security assessment (1997)

Article A practical approach to security assessment Share on Authors: Darrell M. Kienzle The MITRE Corporation The MITRE CorporationView Profile , William A. Wulf Department of Computer Science, University of Virginia Department of Computer Science, University of VirginiaView Profile Authors Info & Claims NSPW '97: Proceedings of the 1997 workshop on New security paradigmsJanuary 1998 Pages 5–16https://doi.org/10.1145/283699.283731Published:01 January 1998 12citation1,234DownloadsMetricsTotal Citations12Total Downloads1,234Last 12 Months4Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Dendrimeric siRNA for Efficient Gene Silencing (2015)

Programmable molecular self-assembly of siRNA molecules provides precisely controlled generation of dendrimeric siRNA nanostructures. The second-generation dendrimers of siRNA can be effectively complexed with a low-molecular-weight, cationic polymer (poly(β-amino ester), PBAE) to generate stable nanostructures about 160 nm in diameter via strong electrostatic interactions. Condensation and gene silencing efficiencies increase with the increased generation of siRNA dendrimers due to a high charge density and structural flexibility.
Managing fast mobility in wireless multi-hop networks with LISP (2011)

The Locator/ID Separation Protocol (LISP) has been developped in recent years in order to solve the scalability issues the current Internet Architecture is facing. Differently from the current addressing system, where end-systems' identifier and location information are merged in one single entity, i.e., the IP address, LISP aims at using two different address spaces to identify and to locate end-systems. Such a separation turns out to be very useful in the context of networks with highly mobile end-systems, where the information "who is where" changes rapidly.
Relaxation mechanism of GaP grown on 001 Si substrates: influence of defects on the growth of AlGaP layers on GaP/Si templates (2021)

The mechanical stability of commercial GaP/Si templates during thermal annealing and subsequent growth of GaP and AlGaP using metal-organic chemical-vapour deposition is investigated. Although the as-grown GaP layer of the template originally presents an excellent surface morphology, annealing at temperatures between 645 ∘C to 845 ∘C to remove the native oxide prior to growth leads to plastic relaxation, accompanied by a variety of defects, including a dense grid of micro-twins. These micro-twins detrimentally affect GaP and AlGaP layers grown subsequently on the template.
Rapid exploration of the epitope coverage produced by an Ebola survivor to guide the discovery of therapeutic antibody cocktails (2020)

Critically, this workflow allows us to probe the epitope landscape of EBOV GP without any prior structural knowledge of the antigen or structural benchmark clones. Incorporating epitope binning on hundreds of antibodies during early stage antibody characterization ensures access to a library's full epitope coverage, aids in the identification of high quality reagents within the library that recapitulate this diversity for use in other studies, and ultimately enables the rational development of therapeutic cocktails that take advantage of multiple mechanisms of action such as cooperative synergistic effects to enhance neutralization function and minimize the risk of mutagenic escape. The use of high-throughput epitope binning during new outbreaks such as the current COVID-19 pandemic is particularly useful in accelerating timelines due to the large amount of information gained in a single experiment.
<title>New facility for large-scale DCG transmission holographic gratings: status and evaluation</title> (2002)

The recent interest of the astronomer community for volume phase holographic gratings is directly related to the enhancement of spectrograph throughput since the grating can rise higher diffraction efficiency. Indeed, dichromated gelatin technology has demonstrated capability for 70-90% efficiency. From the heritage of several diffractive and holographic projects and applications, the Centre Spatial de Liege has recently decided to invest in the large-scale DCG grating technology. This paper will present the new facility presently under construction. The goal is to be ready to respond to the market demand in 2002 with a capacity for producing 30 cm dia. holographic gratings. The challenge is not the size itself but the quality control in each process step. Thanks to the heritage of space instrumentation, CSL is trained to fulfill requirements on product and quality control. Large clean rooms are equipped with DCG coating machine, optical bench, development lab, and conditioning processes. The grating period may range from 325 to 3000 lp/mm. Low frequencies are especially hard to holographically record because it induces a cumbersome set-up. The working wavelength of DCG gratings is limited by the gelatin transmissivity (from 350 nm to 2 micrometers ). But the actual limitation factor in the IR is the refractive index modulation, equivalent to etching depth on ruled gratings: working wavelength of 1.5 micrometers means a need for 3 times the modulation of a visible grating. Large efforts are needed to insure that IR volume-phase gratings can reach efficiency higher than alternative grating technologies. In that field, this paper presents experimental results on small grating samples. A realistic performance goal is discussed to advise the astronomer community of our near-future products.