gebhart/patrepeval huggingface dataset:
In vitroinvestigation of the efficacy of novel diamidines againstTrypanosoma cruzi (2014)

Chagas' disease is a neglected tropical disease caused by Trypanosoma cruzi and constitutes a serious public health problem for Latin America. Its unsatisfactory chemotherapy stimulates the search for novel antiparasitic compounds. Amidines and related compounds exhibit well-known activity towards different microbes including T. cruzi. In this vein, our present aim was to evaluate the biological effect of 10 novel structurally related amidines in vitro against bloodstream and intracellular forms of the parasite as well as their potential toxicity on cardiac cell cultures. Our results show that although active against the extracellular forms, with some of them like DB2247 being 6-fold more effective than benznidazole and displaying very low toxicity (>96 μm), none presented superior trypanocidal effect against intracellular forms as compared with the reference drug. These results may be due to differences in susceptibility profiles related to distinct uptake/extrusion mechanisms and cellular targets between bloodstream and amastigote forms. The present study adds to the knowledge base for the future design of novel amidines that may provide promising activity against T. cruzi.
VIS-NIR Modeling of Hydrangenol and Phyllodulcin Contents in Tea-Hortensia (Hydrangea macrophylla subsp. serrata) (2022)

Hyperspectral data are commonly used for the fast and inexpensive quantification of plant constituent estimation and quality control as well as in research and development applications. Based on chemical analysis, different models for dihydroisocoumarins (DHCs), namely hydrangenol (HG) and phyllodulcin (PD), were built using a partial least squares regression (PLSR). While HG is common in Hydrangea macrophylla, PD only occurs in cultivars of Hydrangea macrophylla subsp. serrata, also known as ‘tea-hortensia’. PD content varies significantly over the course of the growing period. For maximizing yield, a targeted estimation of PD content is needed. Nowadays, DHC contents are determined via UPLC, a time-consuming and a destructive method. In this research article we investigated PLSR-based models for HG and PD using three different spectrometers. Two separate trials were conducted to test for model quality. Measurement conditions, namely fresh or dried leaves and black or white background, did not influence model quality. While highly accurate modeling of HG and PD for single plants was not possible, the determination of the mean content on a larger scale was successful. The results of this study show that hyperspectral modeling as a decision support for farmers is feasible and provides accurate results on a field scale.
Systematic study of the effects of δ-p-doping on 1.3μm dot-in-well lasers (2007)

We systematically studied effects of increasing p-doping concentrations on quantum dot lasers and found: an increase in threshold current, gain and loss; gain profile narrowing; increasing infinite T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> temperature range; and higher k-factor limited bandwidth.
Impact of Diabetes on 10‐Year Outcomes Following ST‐Segment–Elevation Myocardial Infarction: Insights From the EXAMINATION‐EXTEND Trial (2022)

Background Long-term outcomes of ST-segment-elevation myocardial infarction in patients with diabetes have been barely investigated. The objective of this analysis from the EXAMINATION-EXTEND (10-Years Follow-Up of the EXAMINATION trial) trial was to compare 10-year outcomes of patients with ST-segment-elevation myocardial infarction with and without diabetes. Methods and Results Of the study population, 258 patients had diabetes and 1240 did not. The primary end point was patient-oriented composite end point of all-cause death, any myocardial infarction, or any revascularization. Secondary end points were the individual components of the primary combined end point, cardiac death, target vessel myocardial infarction, target lesion revascularization, and stent thrombosis. All end points were adjusted for potential confounders. At 10 years, patients with diabetes showed a higher incidence of patient-oriented composite end point compared with those without (46.5% versus 33.0%; adjusted hazard ratio [HR], 1.31 [95% CI, 1.05-1.61]; <i>P</i>=0.016) mainly driven by a higher incidence of any revascularization (24.4% versus 16.6%; adjusted HR, 1.61 [95% CI, 1.19-2.17]; <i>P</i>=0.002). Specifically, patients with diabetes had a higher incidence of any revascularization during the first 5 years of follow-up (20.2% versus 12.8%; adjusted HR, 1.57 [95% CI, 1.13-2.19]; <i>P</i>=0.007) compared with those without diabetes. No statistically significant differences were found with respect to the other end points. Conclusions Patients with ST-segment-elevation myocardial infarction who had diabetes had worse clinical outcome at 10 years compared with those without diabetes, mainly driven by a higher incidence of any revascularizations in the first 5 years. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT04462315.
V3Ga wire fabricated by the modified jelly roll technique (1984)

V3Ga wire has been fabricated by the modified jelly roll technique for the first time. Critical current densities in magnetic fields to 22 T, critical magnetic fields, and superconducting transition temperatures are reported for this wire as a function of reaction temperature for forming the interfacial V3Ga layer. Superconducting properties of the reacted wire are optimized for reaction temperatures between 550–580 °C. With a reaction temperature of 580 °C, the overall (noncopper) current density of the wire is over 104 amp/cm2 at 19 T.
A Digital Signal Recovery Technique Using DNNs for LEO Satellite Communication Systems (2020)

This article proposes a new digital signal recovery (DSR) technique for next-generation power efficient low Earth orbit (LEO) satellite-to-ground communication systems, which feature additive white Gaussian noise (AWGN) channel and significant power variation. This technique utilizes the prior knowledge [i.e., nonlinearities of radio frequency power amplifiers (RF-PAs)] of space-borne transmitters to improve the quality of the signal received at ground stations by modeling and mitigating the imperfection using deep neural networks (DNNs). Benefiting from its robustness against noise and power variation, the proposed DNN based DSR technique (DNN-DSR), can correct high signal distortions caused by the nonlinearities and hence allows RF-PAs to work close to their saturation region, leading to a high power efficiency of the LEO satellites. This work has been validated by both simulations and experiments, in comparison with the power back-off technique as well as memory polynomial-based DSR solutions. Experimental results show that the DNN-DSR technique can increase the drain efficiency of the space-borne RF-PA from 32.6% to 45% while maintaining the same error vector magnitude as the power back-off technique. It has also been demonstrated that the proposed DNN-DSR technique can handle a signal power variation of 12 dB, which is challenging for conventional solutions.
Characterization and Modeling of Broad Spectrum InAs–GaAs Quantum-Dot Superluminescent Diodes Emitting at 1.2–1.3 $\mu$m (2007)

High-power broadband superluminescent diodes (SLDs) emitting in the 1.2-1.3- <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">mu</i> m region are demonstrated using InAs-GaAs quantum dots (QDs). The highest output powers of ~30-50 mW are achieved using 18 QD layers with p-doped GaAs spacers. At these high powers the device operates in a regime of broad bandwidth (~100 nm) with a spectral dip of ~5 dB between two separate peaks originated by the QD ground and excited states. Spectral calculations performed with a traveling-wave rate equation model show excellent agreement with the experimental data and provide design rules for optimizing the output spectrum. SLD characteristics are presented for two different device structures consisting of tilted and bent waveguides. The latter allows the achievement of higher output powers at lower currents. The coherence properties and the temperature characteristics are also discussed in detail.
Localization of E2A mRNA expression in developing and adult rat tissues. (1993)

E2A helix-loop-helix proteins are involved in the control of various developmental pathways. We show here by in situ hybridization that E2A transcripts are present in most embryonic and adult tissues. However, no E2A expression is detectable in heart and nonproliferative regions of the brain and spinal cord. Highest levels of E2A expression are found in the ependyma cell layer surrounding the cerebral ventricles in the embryonic rat brain. In addition, in the embryo, E2A transcripts were found in secretory cells of the pancreas, the bronchial tubes of the lung, glomeruli of the kidney, and the lining of the stomach. Interestingly, high levels of E2A transcripts are selectively found in the germinal center of the lymphatic nodules in the adult rat spleen. Thus, E2A, like its Drosophila homolog daughterless, is expressed in most tissues. The most notable feature of the E2A expression pattern is its high levels of expression in some areas of rapid cell proliferation and differentiation and in certain epithelial cell types.
Phase- and Self-Injection-Locked Radar for Detecting Vital Signs with Efficient Elimination of DC Offsets and Null Points (2013)

A phase- and self-injection-locked radar is presented for robust vital-sign detection. The dc offset from the clutter is eliminated by using a dual-tuning voltage-controlled oscillator without complex clutter cancellation techniques. Phase noise analysis shows that the proposed radar has the advantages of both phase-locked oscillators and self-injection-locked oscillators to achieve high power spectral signal-to-noise ratio. Path-diversity transmission is employed to eliminate null points and reduce average transmitted power. Experiments demonstrate successful detection of breathing and heartbeat from a distance of 4 m with -22 dBm (6 μW ) average transmitted power.
Anthracycline Cardiomyopathy Is Mediated by Depletion of the Cardiac Stem Cell Pool and Is Rescued by Restoration of Progenitor Cell Function (2009)

Our results raise the possibility that autologous CPCs can be obtained before antineoplastic drugs are given to cancer patients and subsequently administered to individuals who are particularly sensitive to the cardiotoxicity of these agents for prevention or management of heart failure.
SambaNova SN10 RDU:Accelerating Software 2.0 with Dataflow (2021)

The following is intended to outline our general product direction at this time. There is no obligation to update this presentation and the Company’s products and direction are always subject to change. This presentation is intended for information purposes only and may not be relied upon for any purchasing, partnership, or other decisions.
Minimal Geodesics Bundles By Active Contours : Radar Application For Computation Of Most Threathening Trajectories Areas & Corridors (2015)

Publication in the conference proceedings of EUSIPCO, Tampere, Finland, 2000
Photoelectric Synaptic Plasticity Realized by 2D Perovskite (2019)

Abstract Recently, several light‐stimulated artificial synaptic devices have been proposed to mimic photonic synaptic plasticity for neuromorphic computing. Here, the photoelectric synaptic plasticity based on 2D lead‐free perovskite ((PEA) 2 SnI 4 ) is demonstrated. The devices show a photocurrent activation in response to a light stimulus in a neuron‐like way and exhibit several essential synaptic functions such as short‐term plasticity (STP) and long‐term plasticity (LTP) as well as their transmission based on spike frequency control. The strength of synaptic connectivity can be effectively modulated by the duration, irradiance, and wavelength of light spikes. The ternary structure of (PEA) 2 SnI 4 causes it to possess varied photoelectric properties by composition control, which enhances the complexity and freedoms required by neuromorphic computing. The physical mechanisms of the memory effect are attributed to two distinct lifetimes of photogenerated carrier trapping/detrapping processes modulated by controlling the proportion of Sn vacancies. This work demonstrates the great potential of (PEA) 2 SnI 4 as a platform to develop future multifunctional artificial neuromorphic systems.
Platelet function and association of bovine viral diarrhea virus with platelets of persistently infected cattle (2005)

Isolation of BVDV from platelets in the peripheral circulation of cattle immunotolerant to BVDV does not result in altered platelet function or decreases in platelet counts.
Imaging brain morphology with ultrahigh-resolution optical coherence tomography (2003)

The morphology of healthy and pathological human brain tissue, as well as the brain structural organization of various animal models has been imaged <i>in-vitro</i> using ultrahigh resolution optical coherence tomography (UHR OCT). Micrometer-scale OCT resolution (&lt; 2 &mu;m axial resolution) was achieved at different central wavelengths by interfacing three state-of-the-art broad bandwidth light sources (Ti:Al<sub>2</sub>O<sub>3</sub>, &lambda;c = 790 nm, &Delta;&lambda; = 260 nm and P<sub>out</sub> = 50 mW; PCF based laser, &lambda;c = 1150 nm, &Delta;&lambda; = 350 nm and P<sub>out</sub> = 2 W; Fiber laser based light source, &lambda;c = 1350 nm, &Delta;&lambda; = 470 nm and P<sub>out</sub> = 4 mW) to a modular free-space OCT system, utilizing a dynamic focusing and designed for optimal performance in the appropriate wavelength regions. Images acquired from a fixed honeybee brain demonstrated the ability of UHR OCT to image the globular structure of the brain, some fine morphological details such as the nerve fiber bundles connecting the medulla (visual center) to the honeybee eyes, and the interfaces between different tissue layers in the medulla. Tomograms of various human neuropathologies demonstrated the feasibility of UHR OCT to visualize morphological details such as small (~20 &mu;m) calcifications typical for fibrous meningioma, and enlarged nuclei of cancer cells (~10-15 &mu;m) characteristic for many other neuropathologies. In addition UHR OCT was used to image cellular morphology in living ganglion cells.
Complimentary Nano-Electromechanical Carbon Nanotube Switches (2006)

As an alternative to conventional CMOS devices, we are developing a new family of devices called Complementary Nano Electro-Mechanical Switches (CNEMS) using carbon nanotubes as active switching/latching elements. The basic structure of these devices consists of three co-planar carbon nanotubes arranged so that the central nanotube can touch the two side carbon nanotubes upon application of a voltage pulse between them. These devices have very low leakage current, low operation voltages, and they possess built-in energy storage to reduce computation power, resulting in very low overall power dissipation. Additionally, the presence of van der Waals forces endow these devices with latching mechanism for non- volatile memory-mode operation. The devices can also be readily integrated with CMOS allowing easy manufacturability and hybridization with conventional CMOS circuits. The architecture discussed here can dynamically adapt to application workload for optimized performance and reconfigure around defects / variations for reliable operation.
Sketching across design domains: Roles and formalities (2012)

Abstract To complement studies on design sketching within particular phases of design processes in specific design domains, this paper analyzes descriptions of design processes given by designers from a wide variety of fields. This research forms part of a wider project on comparisons across design domains and draws attention to the many types and properties of sketches in different contexts. Further, it focuses on the multiple roles that sketching can take in idea generation, as well as in reasoning and communicating design ideas. In particular this paper examines how the different types and roles of sketches can be more or less formal and how this can lead to misunderstandings.
Analysis of the Fate and Function of Antigen-Specific CD8 T Cells during B Cell Lymphoma Progression. (2004)

Abstract There is now overwhelming evidence that tumor-induced antigen (Ag)-specific T cell tolerance represents a critical problem in tumor immunology. Early studies of CD8 T cell tolerance equated peripheral tolerance with either ignorance or clonal deletion, although more recent evidence has suggested that this may be only partly accurate. While murine modeling outwardly supports the contention that high-affinity tumor-specific CD8 T cell responses are centrally deleted, cognate CD8 T cells displaying an Ag-experienced phenotype can nonetheless be detected in regional draining lymph nodes (dLN) or in non-lymphoid sites where the Ag is present. However, these CD8 T cells are typically deficient in one or more effector functions, including cytokine production, cytotoxicity, or proliferative capacity. To better define the state of Ag-specific CD8 T cell responsiveness in the face of progressive tumor, we adoptively transferred hemagglutinin (HA) Ag-specific Clone 4 (CLN4) CD8 T cells into animals bearing a genetically modified B cell lymphoma expressing HA as a model tumor antigen (A20HA). Analysis of the fate and function of these transferred antigen-specific CD8 T cells revealed that they encountered antigen in vivo, were capable of mounting an initial response to A20HA but this response was not sustained. Indeed, while a prominent CTL activation was observed in the spleen and draining lymph nodes of tumor bearing mice within 14 days of T cell transfer, responses (HA-specific proliferation, IFN-γ production and cytotoxicity) began to wane by day 21 after T cell transfer, and in particular their ability to produce IFN-γ. A similar pattern of transient activation followed by loss of CD8 T cell function has been also observed in an in vivo model of high-dose peptide induced antigen-specific CD8 T cell tolerance. Given our recent demonstration that the disruption of Stat3 signaling in APCs overcomes CD4 T cell tolerance we determined next whether Stat3 deficient APCs may be inherently better at cross-presenting tumor-Ags and elicit therefore a more productive and sustained CD8 T cell response. In an in vitro system in which tumor cells expressing a model tumor antigen (EL4mOVA) were cultured with APCs genetically devoid of Stat3 signaling and anti-OVA CD8 T-cells (OT-I), we found that these T cells displayed an enhanced function relative to antigen-specific CD8 T-cells that encountered antigen on APCs with an intact Stat3 signaling. Currently, we are investigating whether CD8 T-cell tolerance to tumor antigens occurred -or not- in tumor bearing mice with a genetic disruption of Stat3 signaling in APCs. Furthermore, given the emerging role of other members of the STAT family in regulation of APC function, we are exploring whether targeted disruption of Stat1, 4 and 6 can alter the ability of the CD8 T-cell to sustain a protective response or, more importantly to recover function once tolerance is induced.
Compact Modeling Solutions for Oxide-Based Resistive Switching Memories (OxRAM) (2014)

Emerging non-volatile memories based on resistive switching mechanisms attract intense R&amp;D efforts from both academia and industry. Oxide-based Resistive Random Acces Memories (OxRAM) gather noteworthy performances, such as fast write/read speed, low power and high endurance outperforming therefore conventional Flash memories. To fully explore new design concepts such as distributed memory in logic, OxRAM compact models have to be developed and implemented into electrical simulators to assess performances at a circuit level. In this paper, we present compact models of the bipolar OxRAM memory based on physical phenomenons. This model was implemented in electrical simulators for single device up to circuit level.
Vβ T Cell Repertoire of CD8+ Splenocytes Selected on Nonpolymorphic MHC Class I Molecules (2000)

In this work, we have studied the role of the MHC class Ib molecules in the selection and maintenance of CD8(+) T splenocytes. We have compared the CD8(+) T cell repertoires of wild-type, H-2K-deficient, H-2D-deficient, or double knockout C57BL/6 mice. We show that the different CD8(+) repertoires, selected either by class Ia and class Ib or by class Ib molecules only, use the various V alpha (AV) and V beta (BV) rearrangements in the same proportion and without biases in the CDR3 size distribution. Furthermore, we have estimated the size of the BV repertoire in the four different strains of mice. Interestingly, we have found that the BV repertoire size is proportional to the overall number of CD8(+) splenocytes. This observation implies that BV diversity is positively correlated with the number of CD8(+) cells, even when the number of CD8(+) splenocytes is dramatically reduced (90% in the double knockout mice).
Figure S7 from Oral IRAK-4 Inhibitor CA-4948 Is Blood-Brain Barrier Penetrant and Has Single-Agent Activity against CNS Lymphoma and Melanoma Brain Metastases (2023)

&lt;p&gt;Supplemental Figure 7. Pattern of pNF-κB expression in human CNS tumors.&lt;/p&gt;