gebhart/patrepeval huggingface dataset:
Brain metastasis from renal cell carcinoma: Presentation, recurrence, survival and implications for systemic therapy (2008)

5097 Background: Patients with renal cell carcinoma brain metastasis (RCCBM) are frequently excluded from clinical trials. NCCN guidelines do not give clear recommendations regarding central nervous system (CNS) surveillance or therapy. We set out to define who should be screened and who should be considered for clinical trials after treatment of CNS lesions. Methods: A database of information was reviewed to determine presentation, clinical symptoms, number and size of lesions, use of and response to systemic therapy, treatment of BM, CNS disease free survival after treatment of original BM (CNS recurrence), and overall survival from time of diagnosis of BM. Results: A total of 138 patients with RCCBM were identified of whom 95% underwent treatment for their BM. Clear cell histology accounted for 92% of patients and 93% of patients had concomitant metastasis. Patients had CNS symptoms in 67% of cases. Symptomatic CNS tumors were larger (2.1 vs 1.3 cm, p <0.001) and more likely to receive a craniotomy (p<0.001). Number of lesions did not affect symptoms or risk of craniotomy. Median overall survival after diagnosis of BM was 10.7 months and the 1, 2, and 5 year survival was 48%, 30% and 12%, respectively. Performance status was the only independent predictor for survival (HR 6.1 p<0.001, CI 3–12.6). Local CNS recurrence was observed in 6.5% of patients, but new CNS lesions developed in 48%. Median time to CNS recurrence was 9 months. The initial number of CNS lesions (> 1 tumor) was an independent risk factors for CNS recurrence (HR 3.72, p <0.001, CI 2.0–7.1) Those with 1 and >1 BM had median CNS recurrence free survival of 13 and 4 months (p<0.001). Of patients receiving IL-2 based therapy after CNS treatment, 3/18 had an objective response. Conclusions: Patients with metastatic RCC should be evaluated with CNS imaging allowing identification of smaller lesions amenable to radiosurgery. Some patients exhibit prolonged survival and those with good performance status should be treated aggressively. Those with a solitary BM are less likely to recur and can be considered for therapy despite concerns over CNS penetration. No significant financial relationships to disclose.
Preparation and Characterization of Pt/γ-Al2O3 Model Catalyst on NiAl Alloy (2010)

Extended abstract of a paper presented at Microscopy and Microanalysis 2010 in Portland, Oregon, USA, August 1 – August 5, 2010.
Using NDT for thickness measurement of shotcrete rock support systems in underground mines (2000)

Shotcrete is quickly becoming the economical material of choice for rock support systems in underground mines throughout Canada. Although shotcrete technology has gained acceptance in the mining industry, there are some problems which have emerged with respect to quality assessment and thickness measurement of the liner. This paper presents recent tests performed with a miniature seismic reflection device developed primarily for thickness measurement of this heterogeneous liner. Work was performed on site in an underground mine in Ontario, Canada. This paper also presents the results from laboratory tests performed on fiber reinforced an non reinforced shotcrete panels which were used to asses the P-wave velocity in both materials. The results of these tests were used in a second on site investigation. The NDT thickness measurements showed good agreement with the results obtained by mine personnel with conventional methods.
HOL-TestGen 1.5.0 user guide (2010)

Permission is granted to make and distribute verbatim copies of this manual provided the copyright notice and this permission notice are preserved on all copies. Permission is granted to copy and distribute modified versions of this manual under the conditions for verbatim copying, provided that the entire resulting derived work is distributed under the terms of a permission notice identical to this one. Permission is granted to copy and distribute translations of this manual into another language, under the above conditions for modified versions, except that this permission notice may be stated in a translation approved by the Free Software Foundation. Note: This manual describes HOL-TestGen version 1.7.0 (rev. 9482).Contents
Sensorless Speed Control of Synchronous Motors: Analysis and Mitigation of Stator Resistance Error (2015)

Direct torque control-based sensorless speed control (DTC-SSC) of a synchronous motor is a high performance and reliable approach for the control of speed and stator flux modulus. This paper proposes an analytical method to study the effect of error in estimation of stator resistance on the stability of a synchronous motor controlled via DTC-SSC approach, a reliable resistance estimator based on the angle between the stator flux and current vectors with no need to solve nonlinear equations, and a modified structure for sensorless speed control of synchronous motors based on this estimator. Simulation and experimental case studies validate the proposed stability analysis and the resistance estimator.
ChemInform Abstract: NUCLEOPHILER CHARAKTER VON ALKYLRADIKALEN 4. MITT. REAKTIVITAET GEGENUEBER CHINOLIN UND CHINOXALIN (1971)

Abstract Konkurrierende Reaktionen von Chinolin und Chinoxalin gegenüber prim., sek. und tert. C 2 ‐ bis C 4 ‐Alkylradikalen werden untersucht.
Adsorption of Poly(vinylformamide-co-vinylamine) Polymers (PVFA-co-PVAm) on Copper (2012)

The adsorption of poly(vinylformamide) (PVFA) and its derivative statistical copolymer poly(vinyl-formamide-co-vinylamine) (PVFA-co-PVAm) on metallic copper and copper oxide particles as well as planar copper surfaces was studied as a function of the degree of hydrolysis of PVFA, the pH, and the polymer concentration in solution. The chemical composition and molecular structure of the PVFA-co-PVAm layers were investigated by surface-sensitive spectroscopic methods such as XPS, DRIFT spectroscopy, and ellipsometry. The findings allowed us to explain the adsorption mechanisms and the forces driving the PVFA-co-PVAm adsorption. It was shown that PVFA-co-PVAm layers thicker than 30 nm are able to protect the planar copper surface against corrosive attack.
Enhanced processing: sub-50 nm features with 0.8-μm DOF using a binary reticle (2003)

With the ever-increasing demand for reducing the size of devices on a chip, one frequently meets the lithographic challenge of printing very small lines on a wafer. The rapidly shrinking process latitudes, especially the depth-of-focus (DOF), really become a burden when trying to print sub-80nm resist lines on a wafer with 193nm lithography. In this paper, we report on a method that is capable of enlarging the process windows for printing small lines, while also reducing a line collapse issue, by using an enhanced resist processing procedure. In this procedure, the PEB time duration, in combination with the exposure dose, is used as a tuning process parameter. It is shown that, by using this procedure, a significant increase in DOF is obtained for printing small (down to 40nm) isolated and semi-dense lines, while the pitch is not scaled down. While using a binary mask and annular 193nm illumination with a NA of 0.63 and s of 0.87/0.57, we show that it is possible to print 50nm lines on a 240nm pitch with 0.8 micron DOF, whereas the standard process, using the vendor recommended PEB, can only print 80nm lines with a comparable DOF. The large process enhancement, among which the reduced curvature in the Bossung plots, is explained by the more efficient use of the acid and quencher present in the photoresist, as well as by the peculiarities of acid diffusion near regions where quencher is remaining. The results obtained are explained by a compact resist model in which acid-quencher reaction-diffusion is incorporated.
Error correction method for R-DAT and its evaluation (2005)

Decoding method of error correcting codes used in R-DAT has been examined. High ability for both error correction and detection is required in digital audio systems, because undetected error causes a shock noise in the reproduced sound. It is also required to correct a long burst error due to dropouts in the magnetic tape. A model of error occurrence in R-DAT was proposed with suitable parameters characterizing the data transmission property. Based on the model, a simulation for error correction procedure was carried out to evaluate the ability of the error correction method. As a result, a powerful decoding algorithm suitable for R-DAT has been developed.
Configurable cameras with MMS architecture (2018)

Monocentric multiscale (MMS) lens architecture provides a versatile, compact, high information efficiency and low-cost way of building panoramic imagers which can be easily tailored to various application scenarios. MMS lens consists of two parts, one concentric spherical objective lens with large aperture in front and an array of small aperture microcameras in rear. This front objective collects incoming light and forms a curved focal surface which is then being segmented and relayed by the secondary array optics. Since the front objective is a spherically symmetric element, the configuration of the secondary array optics determines the overall imaging space. Each microcamera can be used as a building block and offers the flexibility of compositing myriad of FoV coverage and easy re-configuration. Another merit of this modular design is that the design of the secondary optics can be varied from channel to channel. In this way, we can construct an imaging system with multi-focal lengths, multi-aperture sizes and other multi-specifications. This varied channel property allows for sub-region adaptive imaging ability. Finally, if multiple MMS lenses are co-designed and used jointly, some combinational functions can be accomplished. To verify these virtues of MMS architecture, we present several design examples in this paper. A rectangular and a 360-degree ring configuration are demonstrated and show different packing choices. Then we illustrate a multi-focal design which shows secondary optics of different channels are modified for a relatively uniform sampling rate of targeted area.
Genetic chemistry: Tools for gene therapy coming from unexpected directions (2000)

Overcoming the limitations of foreign gene delivery to eukaryotic cells is a crucial path toward human gene therapy. Over the last 5 years, this challenge has been approached in different ways. The design and synthesis of novel cationic lipids for gene delivery was a central preoccupation to obtain increased transgene expression. Significant progress was achieved for in vitro and in vivo gene delivery by designing a series of geometrically differing lipopolyamines. First, the geometry of lipopolyamines affects the final transgene expression. Second, introduction of DNA complexing peptides into lipopolyamine/DNA complexes is advantageous for transgene expression in the presence of serum. In a third approach, the introduction of different cationic entities such as polyguanidinium or polycyclic guanidinium instead of the polyamine head group may favor tissue-specific gene delivery. In a fourth approach, introduction of a reduction-sensitive group in lipopolyamines lead to increased transgene expression as compared to nonreducible lipopolyamines. Finally, the design and synthesis of novel nonelectrostatic DNA complexing agents represent a new promising approach for in vivo DNA delivery. The last exciting challenge to be faced was the site-specific chemical ligation to plasmid DNA as a tool for plasmid DNA targeting and intracellular localization of complexes. Together with the development of the different approaches, the physicochemical characterization of the different gene delivery systems, as well as their intracellular fate, were studied. These studies are of great importance for understanding the differing transfection efficiency obtained for different types of DNA complexes, thus a more rational base can be used for designing new generations of highly efficient nonviral self-assembling systems for gene delivery. Drug Dev. Res. 50:566–572, 2000. © 2000 Wiley-Liss, Inc.
Feasibility study of physical-layer network coding in 802.11p VANETs (2014)

Vehicular Ad-hoc Network (VANET) is expected to play a major role in improving road safety and traffic efficiency in people's daily life. However, the main issue in VANETs remains to be intermittent node connectivity and relatively short contact duration due to the high mobility of vehicles. Physical-layer Network Coding (PNC) that enables data exchange within a much shorter airtime (e.g., twice faster than traditional scheduling) favors the highly-dynamic link condition in vehicular environments and hence appears to be a powerful tool in VANETs. One of the most important challenges in applying PNC to VANETs comes from the Doppler shift due to high-speed vehicle motion, which leads to carrier frequency offset (CFO) and hence introduces inter-carrier interference (ICI) that degrades the bit error rate performance. In this paper, we investigate the impact of motion-induced CFO/ICI on the overall signal detection. In particular, we study whether PNC in VANETs can be made feasible with conventional equalization techniques that suppress the effect of CFO. We found that PNC suffers only a 3 dB SINR penalty in the worst case compared with generic point-to-point (P2P) communications, and generally PNC is feasible in vehicular environments even if the transmission powers of source nodes cannot be finely controlled.
The Pseudomonas type III effector HopQ1 activates cytokinin signaling and interferes with plant innate immunity (2013)

We characterized the molecular function of the Pseudomonas syringae pv. tomato DC3000 (Pto) effector HopQ1. In silico studies suggest that HopQ1 might possess nucleoside hydrolase activity based on the presence of a characteristic aspartate motif. Transgenic Arabidopsis lines expressing HopQ1 or HopQ1 aspartate mutant variants were characterized with respect to flagellin triggered immunity, phenotype and changes in phytohormone content by high-performance liquid chromatography-MS (HPLC-MS). We found that HopQ1, but not its aspartate mutants, suppressed all tested immunity marker assays. Suppression of immunity was the result of a lack of the flagellin receptor FLS2, whose gene expression was abolished by HopQ1 in a promoter-dependent manner. Furthermore, HopQ1 induced cytokinin signaling in Arabidopsis and the elevation in cytokinin signaling appears to be responsible for the attenuation of FLS2 expression. We conclude that HopQ1 can activate cytokinin signaling and that moderate activation of cytokinin signaling leads to suppression of FLS2 accumulation and thus defense signaling.
Relationship between surface dipole, work function and charge transfer:  Some exceptions to an established rule (2003)

Local-density-functional calculations are used to study the change of work functions induced by a layer of adsorbates. We investigated and compared the work function of a monolayer of Mo, Ag, Au, Fe, Co, Ni, Nb, Li, N, and O on W(100), W(110), W(211), and W(111) surfaces. While many systems obey the commonly accepted rule that electronegative adsorbates increase the work function of the surface, we find some exceptions. For example, overlayers of Fe, Co, and Ni increase the work function of W(100), W(211), and W(111), but decrease the work function of the W(110) surface, although the charge transfer is the same in all orientations. We found that even a layer of oxygen can decrease the work function of W(100), although there are always electrons transferred from the W substrate to the oxygen adsorbates. In order to understand these results, we established the relationship between surface dipole density and work function within the framework of local-density formalism. It turns out that subtle details of the charge transfer can determine the sign and magnitude of surface dipole change, leading to a strong dependence on the orientation of the substrate, with the consequence that the work-function changes are not always governed by the sign and quantity of adsorbate induced charge transfer.
Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation (2014)

Aurora A and JAK2 kinases are involved in cell division and tumor cell survival, respectively. Here we demonstrate that ectopic expression of Aurora A and JAK2 together is more effective than each alone at inducing non-transformed cells to grow in an anchorage-independent manner and to invade. Furthermore, siRNA silencing or pharmacological inhibition of Aurora A and JAK2 with Alisertib and Ruxolitinib, respectively, is more effective than blocking each kinase alone at suppressing anchorage-dependent and -independent growth and invasion as well as at inducing apoptosis. Importantly, we have developed dual Aurora and JAK inhibitors, AJI-214 and AJI-100, which potently inhibit Aurora A, Aurora B and JAK2 in vitro. In human cancer cells, these dual inhibitors block the auto-phosphorylation of Aurora A (Thr-288) and the phosphorylation of the Aurora B substrate histone H3 (Ser-10) and the JAK2 substrate STAT3 (Tyr-705). Furthermore, AJI-214 and AJI-100 inhibit anchorage dependent and independent cell growth and invasion and induce G2/M cell cycle accumulation and apoptosis. Finally, AJI-100 caused regression of human tumor xenografts in mice. Taken together, our genetic and pharmacological studies indicate that targeting Aurora A and JAK2 together is a more effective approach than each kinase alone at inhibiting malignant transformation and warrant further advanced pre clinical investigations of dual Aurora A/JAK2 inhibitors as potential anti tumor agents.
The first completed genome sequence from a teleost fish (Fugu rubripes) adds significant diversity to the nuclear receptor superfamily (2003)

Defining complete sets of gene family members from diverse species provides the foundation for comparative studies. Using a bioinformatic approach, we have defined the entire nuclear receptor complement within the first available complete sequence of a non-human vertebrate (the teleost fish Fugu rubripes). In contrast to the human set (48 total nuclear receptors), we found 68 nuclear receptors in the Fugu genome. All 68 Fugu receptors had a clear human homolog, thus defining no new nuclear receptor subgroups. A reciprocal analysis showed that each human receptor had one or more Fugu orthologs, excepting CAR (NR1I3) and LXRbeta (NR1H2). These 68 receptors add striking diversity to the known nuclear receptor superfamily and provide important comparators to human nuclear receptors. We have compared several pharmacologically relevant human nuclear receptors (FXR, LXRalpha/beta, CAR, PXR, VDR and PPARalpha/gamma/delta) to their Fugu orthologs. This comparison included expression analysis across five Fugu tissue types. All of the Fugu receptors that were analyzed by PCR in this study were expressed, indicating that the majority of the additional Fugu receptors are likely to be functional.
Therapeutic siRNA for drug-resistant HER2-positive breast cancer (2016)

HER2 is overexpressed in about 20% of breast cancers and contributes to poor prognosis. Unfortunately, a large fraction of patients have primary or acquired resistance to the HER2-targeted therapy trastuzumab, thus a multi-drug combination is utilized in the clinic, putting significant burden on patients. We systematically identified an optimal HER2 siRNA from 76 potential sequences and demonstrated its utility in overcoming intrinsic and acquired resistance to trastuzumab and lapatinib in 18 HER2-positive cancer cell lines. We provided evidence that the drug-resistant cancer maintains dependence on HER2 for survival. Importantly, cell lines did not readily develop resistance following extended treatment with HER2 siRNA. Using our recently developed nanoparticle platform, systemic delivery of HER2 siRNA to trastuzumab-resistant tumors resulted in significant growth inhibition. Moreover, the optimal HER2 siRNA could also silence an exon 16 skipped HER2 splice variant reported to be highly oncogenic and linked to trastuzumab resistance.
Synthesis of triazolopyridines and triazolopyrimidines using a modified Mitsunobu reaction (2007)

Triazolopyridines and triazolopyrimidines were synthesized using a modified Mitsunobu reaction starting from acylated 2-hydrazinopyridines and acylated-hydrazinopyrimidines under mild conditions.
Color-Generating 1D PC Dichroic Filter on Cu(In,Ga)(S,Se)2 Thin-Film Photovoltaic Cells for Building Integrated Photovoltaics (2018)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text G. Y. Yoo, W. Kim, B. K. Min, and Y. R. Do, "Color-Generating 1D PC Dichroic Filter on Cu(In,Ga)(S,Se)2 Thin-Film Photovoltaic Cells for Building Integrated Photovoltaics," in Advanced Photonics 2018 (BGPP, IPR, NP, NOMA, Sensors, Networks, SPPCom, SOF), OSA Technical Digest (online) (Optica Publishing Group, 2018), paper JTu2A.36. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Figure S2 from JAK1/STAT3 Activation through a Proinflammatory Cytokine Pathway Leads to Resistance to Molecularly Targeted Therapy in Non–Small Cell Lung Cancer (2023)

&lt;p&gt;Figure S2. Downstream pathway molecules activated by IL6 family proinflammatory cytokine stimulation in NSCLC cells. Five NSCLC cell lines were cultured with an IL6 family cytokine (rhIL6, rhOSM, rhLIF; 1 ng/mL) for the indicated time period under serum-starved conditions. Cell lysates were analyzed for the proteins shown by Western blotting.&lt;/p&gt;
Communication Orale : "Piles à combustible pas procédés plasmas (projet PCP)" (2008)

Les Rendez-Vous Carnot / R&D Network, Versailles (78) - Palais des Congrès - 19 et 20 Mars 2008
Changes in Handset Performance Measures due to Spherical Radiation Pattern Measurement Uncertainty (2005)

An important characteristic of a mobile handset is its ability to receive and transmit power. One way to characterize the performance of a handset in this respect is to use measurements of the spherical radiation pattern from which the total radiated power (TRP), total isotropic sensitivity (TIS), and mean effective gain (MEG) can be computed. Often this kind of measurements are made with a phantom head next to the handsets in order to simulate the influence of a real user. The measured radiation patterns are only expected to be repeatable if the same setup is used, i.e., the same phantom and the same mounting of the handset on the phantom. In this work the influence of mounting errors on the TRP, TIS, and MEG is investigated. Knowledge about the error due to incorrect mounting is necessary in determining requirements for both the mounting accuracy as well as for other parts of the measurement system that may introduce errors in standardized performance measurements. Radiation patterns of six handsets have been measured while they were mounted at various offsets from the reference position defined by the Cellular Telecommunications &amp; Internet Association (CTIA) certification. The change in the performance measures are investigated for both the GSM-900 and the GSM-1800 band. Despite the deliberately large deviations from the reference position, the changes in TRP and TIS are generally within ±0.5dB with a maximum of about 1.4dB. For the MEG values the results depend on the orientation of the handset with respect to the environment. Standard deviations up to about 0.5dB and a maximum deviation of about 1.6dB were found.