gebhart/patrepeval huggingface dataset:
Continual and Robust Estimation of Camera Parameters in Broadcasted Sports Games (2009)

This dissertation investigates the automatic estimation of camera parameters in television broadcasts of sports games played on courts or fields. <br> We present a system that is capable of automatically initializing and tracking the camera parameters of rotating and zooming cameras. An initial calibration of constant parameters of a particular camera of interest is supported using minimal manual effort. The system can then identify sequences recorded by this camera and differentiate them from slow-motion replays or intercuts of other cameras. The reinitialization after cuts or cross-fades is performed automatically using visible field lines. The dynamic camera parameters of the sequence that follows are then continuously determined through optimization techniques, drawing upon motion estimation and field line detection. <br> Our approach is characterized by a high degree of robustness and efficiency.
Comprehensive mutational profiling in advanced systemic mastocytosis (2013)

To explore mechanisms contributing to the clinical heterogeneity of systemic mastocytosis (SM) and to suboptimal responses to diverse therapies, we analyzed 39 KIT D816V mutated patients with indolent SM (n = 10), smoldering SM (n = 2), SM with associated clonal hematologic nonmast cell lineage disorder (SM-AHNMD, n = 5), and aggressive SM (n = 15) or mast cell leukemia (n = 7) with (n = 18) or without (n = 4) AHNMD for additional molecular aberrations. We applied next-generation sequencing to investigate ASXL1, CBL, IDH1/2, JAK2, KRAS, MLL-PTD, NPM1, NRAS, TP53, SRSF2, SF3B1, SETBP1, U2AF1 at mutational hotspot regions, and analyzed complete coding regions of EZH2, ETV6, RUNX1, and TET2. We identified additional molecular aberrations in 24/27 (89%) patients with advanced SM (SM-AHNMD, 5/5; aggressive SM/mast cell leukemia, 19/22) whereas only 3/12 (25%) indolent SM/smoldering SM patients carried one additional mutation each (U2AF1, SETBP1, CBL) (P < .001). Most frequently affected genes were TET2, SRSF2, ASXL1, CBL, and RUNX1. In advanced SM, 21/27 patients (78%) carried ≥3 mutations, and 11/27 patients (41%) exhibited ≥5 mutations. Overall survival was significantly shorter in patients with additional aberrations as compared to those with KIT D816V only (P = .019). We conclude that biology and prognosis in SM are related to the pattern of mutated genes that are acquired during disease evolution.
Parallel processing and analysis of thermographic data (2002)

Pulsed thermography has become a widely used technique for a variety of manufacturing and in-service applications in the energy, aerospace and automotive industries. However, inspection of large structures (e.g. aircraft rudders, elevators and stabilizers) poses a challenge, since data can be acquired quickly, but serial processing and analysis of individual files may require several additional hours. Furthermore, the ability of pulsed thermography to evaluate massive structures, or deeply buried defects, is limited by the inherent effects of thermal diffusion. By applying a novel reconstruction technique [1] to the time evolution of each pixel from the raw data set, we have been able to reduce the size of the original data structure by an order of magnitude, and significantly increase its temporal signal to noise content. The net result is a compact, noise reduced data structure that is easily manipulated. In fact, multiple data sets can be manipulated simultaneously, so that an entire array of data sets acquired from a large structure inspection can be analyzed at once. Automated processing and depth measurement can also be performed on the array of data sets. Examples on aircraft and turbine engine data will be presented.
Gene mapping in <i>Mus musculus</i>by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2 (1977)

Chinese hamster X mouse somatic cell hybrids segregating mouse chromosomes were examined for their mouse chromosome content using trypsin-Giemsa (GTG) banding and Hoechst 33258 staining techniques. Simultaneously, they were scored for the presence of 24 mouse enzymes. The results confirm the assignments of 11 genes previously mapped by sexual genetics: Dip-1 and Id-1 to chromosome 1; Pgm-2 and Pgd to 4; Pgm-1 to 5; Gpi-1 to 7; Gr-1 to 8; Mpi-1 and Mod-1 to 9; Np-1 and Es-10 to 14. They also confirm chromosomally the assignments of 3 genes that were made by other somatic cell genetic studies: Aprt to 8; Hprt and alpha-gal to the X chromosome. But most importantly, four enzyme loci are assigned to four chromosomes that until now were not known to carry a biochemical marker which is expressed in cultured cells: Trip-1 to 10; Dip-2 to 18; Acp-1 to 12; and Ak-1 to 2. Cytogenetic examination of clones showing discordant segregation of HPRT and A-GAL, suggested the assignment of alpha-gal to region XE leads to XF of the mouse X chromosome. The cytologic studies provide a comparison between data from sexual genetics and somatic cell hybrids and validate hybrid cell techniques. They provide evidence of the reliability of scoring chromosomes by GTG and Hoechst staining and stress the importance of identifying clones with multiple chromosome rearrangements. Striking examples of norandom segregation of mouse chromosomes were observed in these hybrids with preferential retention of 15 and segregation of 11 and the Y chromosome.
Genome-wide patterns of differentiation over space and time in the Queensland fruit fly (2020)

The Queensland fruit fly, Bactrocera tryoni, is a major pest of Australian horticulture which has expanded its range in association with the spread of horticulture over the last ~ 150 years. Its distribution in northern Australia overlaps that of another fruit fly pest to which some authors accord full species status, Bactrocera aquilonis. We have used reduced representation genome-wide sequencing to genotype 359 individuals taken from 35 populations from across the current range of the two taxa, plus a further 73 individuals from six of those populations collected 15-22 years earlier. We find significant population differentiation along an east-west transect across northern Australia which likely reflects limited but bidirectional gene flow between the two taxa. The southward expansion of B. tryoni has led to relatively little genetic differentiation, and most of it is associated with a move into previously marginal inland habitats. Two disjunct populations elsewhere in Australia and three on Melanesian islands are each clearly differentiated from all others, with data strongly supporting establishment from relatively few founders and significant isolation subsequently. Resequencing of historical samples from one of the disjunct Australian populations shows that its genetic profile has changed little over a 15-year period, while the Melanesian data suggest a succession of 'island hopping' events with progressive reductions in genetic diversity. We discuss our results in relation to the control of B. tryoni and as a model for understanding the genetics of invasion and hybridisation processes.
Superconducting Transition in Electron-Doped 12CaO&middot;7Al<SUB>2</SUB>O<SUB>3</SUB> (2008)

It was reported that a mixed light metal oxide compound, 12CaO·7Al2O3 (C12A7), which is known as a constituent of aluminous cement, became a superconductor at an ambient pressure by the exclusive replacement of extra-framework oxygen ions in subnanometer-sized crystallographic cages with electrons. Temperature dependences of resistivity, magnetic susceptibility, and magnetic field dependent resistivity of single-crystals and thin films revealed superconducting transition at temperature (Tc) of ∼0.4 K and a critical magnetic field of ∼30 mT. Tc varies 0.2–0.4 K with the electron concentration. The interaction of the anionic electrons in the free space (cages) with the cationic framework may be responsible for the emergence of the superconducting state.
Cushing Syndrome Caused by Adrenocortical Tumors and Hyperplasias (Corticotropin- Independent Cushing Syndrome) (2008)

Endogenous Cushing syndrome (CS) is caused by excess adrenal glucocorticoid secretion that is adrenocorticotropin (ACTH)-dependent or independent; ACTH-independent adrenocortical causes of CS account for up to 20% of CS in adults, and 15% in children over age 7 years. In younger children, ACTH-independent CS may account for as many as half of the CS cases. In both adults and children, adrenocortical lesions causing CS include the common, isolated and sporadic, solitary cortisol-producing adenoma, the rare adrenocortical cancer, and a spectrum of recently recognized, bilateral hyperplasias (bilateral adrenocortical hyperplasias, BAHs): micronodular adrenal disease and its pigmented variant, primary pigmented nodular adrenocortical disease are mostly genetic processes. Macronodular BAHs, ACTH-independent macronodular hyperplasia or massive macronodular adrenocortical disease are less frequently genetic and almost never present in children (except in McCune-Albright syndrome); they present often with atypical CS in middle-aged or elderly adults. The majority of benign adrenocortical tumors associated with CS are associated with defects of the cAMP signaling pathway, whereas adrenal cancer is linked to aberrant expression of growth factors and germline or somatic mutations of tumor suppressor genes such as TP53. Adrenalectomy is the preferred mode of treatment for all adrenocortical causes of CS.
6α-hydroxylated bile acids mediate TGR5 signalling to improve glucose metabolism upon dietary fiber supplementation in mice (2022)

Modulation of the gut microbiota with oligofructose enriches bacteria involved in 6α-hydroxylated bile acid production and leads to TGR5-GLP1R axis activation to improve body weight and metabolism under western-style diet feeding in mice.
Dirac Dispersion in Two-Dimensional Photonic Crystals (2012)

We show how one may obtain conical (Dirac) dispersions in photonic crystals, and in some cases, such conical dispersions can be used to create a metamaterial with an effective zero refractive index. We show specifically that in two-dimensional photonic crystals with <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mi>C</mml:mi><mml:mrow><mml:mn>4</mml:mn><mml:mi>v</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> symmetry, we can adjust the system parameters to obtain accidental triple degeneracy at Γ point, whose band dispersion comprises two linear bands that generate conical dispersion surfaces and an additional flat band crossing the Dirac-like point. If this triply degenerate state is formed by monopole and dipole excitations, the system can be mapped to an effective medium with permittivity and permeability equal to zero simultaneously, and this system can transport wave as if the refractive index is effectively zero. However, not all the triply degenerate states can be described by monopole and dipole excitations and in those cases, the conical dispersion may not be related to an effective zero refractive index. Using multiple scattering theory, we calculate the Berry phase of the eigenmodes in the Dirac-like cone to be equal to zero for modes in the Dirac-like cone at the zone center, in contrast with the Berry phase of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mrow><mml:mi>π</mml:mi></mml:mrow></mml:math> for Dirac cones at the zone boundary.
<title>Wavelet processing workstation: an interactive MATLAB-based computational tool for wavelet processing</title> (1995)

We present a highly powerful, modular, and interactive software tool for the analysis of time- frequency coherent signals via wavelet transformations. A major design goal of the Wavelet Signal Processing Workstation (WSPW) is to maximize ease of use while minimizing programming complexity. As such, the WSPW makes ample use of graphical mouse driven user interfaces and, in turn, allows powerful signal processing, classification, and identification techniques to be rapidly implemented and tested. Because it has been developed using MATLAB, the WSPW is easily extensible and inherently portable between varying system architectures. Although the emphasis of this paper is on the wavelet representation of signals, the WSPW has proven itself a valuable tool in applications including radar source identification and signal classification.
Steering through Successive Objects (2018)

We investigate stroking motions through successive objects with styli. There are several promising models for stroking motions, such as crossing tasks, which require endpoint accuracy of a stroke, or steering tasks, which require continuous accuracy throughout the trajectory. However, a task requiring users to repeatedly steer through constrained path segments has never been studied, although such operations are needed in GUIs, e.g., for selecting icons or objects on illustration software through lassoing. We empirically confirmed that the interval, trajectory width, and obstacle size significantly affect the movement speed. Existing models can not accurately predict user performance in such tasks. We found several unexpected results such as that steering through denser objects sometimes required less times than expected. Speed profile analysis showed the reasons behind such behaviors, such as participants' anticipation strategies. We also discuss the applicability of exiting performance models and revisions.
Dopamine reduces slow outward current and calcium influx in burst- firing neuron R15 of Aplysia (1984)

Dopamine's effect on calcium influx into the bursting neuron, R15, of Aplysia californica was tested by tail current measurements and by measurement of absorbance of intracellular Arsenazo III, a calcium-sensitive indicator. Slow outward tail currents were elicited by subthreshold depolarization in voltage clamp and were demonstrated to be dependent upon transient increases in intracellular calcium activity, (Ca)i), using calcium-free seawater, calcium blockers (Mn2+ and La3+), and intracellular injection of EGTA. Dopamine reduces these tail currents as it reduces the slow inward current. Next, the transient elevations of (Ca)i accompanying subthreshold depolarization were measured directly in Arsenazo III-loaded neurons. Dopamine did not reduce the rise in (Ca)i measured in the soma during depolarization. However, when absorbance of the axodendritic region was monitored, dopamine did reduce calcium influx. Voltage monitoring in the axon indicated that the reduced calcium influx could not simply be ascribed to altered space clamp. In keeping with the apparent axodendritic location of dopamine action, isolation of the soma by ligation of the axon markedly reduced the dopamine response. Dopamine seems to reduce calcium influx into R15, but this effect is topographically limited to nonsomatic membrane, an area of the neuron not usually monitored in optical studies of (Ca)i.
Regulatory genes in the androgen production, uptake and conversion (APUC) pathway in advanced prostate cancer (2022)

The androgen receptor (AR) signaling pathway regulates the progression of prostate cancer (PC). Metastatic castration-resistant prostate cancer (mCRPC) patients generally receive AR-targeted therapies (ART) or androgen-deprivation therapies (ADT) with the initial response; however, resistance is inevitably observed. Prior studies have shown activity and upregulation of a family of androgen production, uptake, and conversion - APUC genes - based on genomic analyses of patient germlines. Genetic variants of some APUC genes, such as the conversion gene, HSD3B1, predict response to second-generation androgen-targeted therapies. Studies have begun to elucidate the overall role of APUC genes, each with unique actionable enzymatic activity, in mCRPC patient outcomes. The current role and knowledge of the genetic and genomic features of APUC genes in advanced prostate cancer and beyond are discussed in this review. These studies inform of how interpreting behavior of APUC genes through genomic tools will impact the treatment of advanced prostate cancer.
Modeling the heteroleptic equilibria of organized molecular systems by using a double-titration technique: a novel determination of the fundamental equilibrium constants in a ternary system involving a macrocyclic cobalt(II) complex, dioxygen, and competing axial ligands (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModeling the heteroleptic equilibria of organized molecular systems by using a double-titration technique: a novel determination of the fundamental equilibrium constants in a ternary system involving a macrocyclic cobalt(II) complex, dioxygen, and competing axial ligandsNaidong Ye and Daryle H. BuschCite this: Inorg. Chem. 1991, 30, 8, 1815–1819Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April 1991https://pubs.acs.org/doi/10.1021/ic00008a025https://doi.org/10.1021/ic00008a025research-articleACS PublicationsRequest reuse permissionsArticle Views40Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Follicular Dendritic Cell (FDC)-Induced Microrna-Mediated up-Regulation of PRDM1 and Down-Regulation of BCL6 in Germinal Center B Lymphocytes: A Potential Mechanism for B-Cell Differentiation. (2009)

Abstract Abstract 4588 B-cell differentiation process is tightly regulated by suppression or induction of specific transcription factors. Among various transcriptional regulators, BCL6 and PRDM-1 are master regulators for germinal center (GC) formation and terminal B-cell differentiation. Dysregulation of BCL6 and PRDM-1 have been associated with lymphomagenesis. However how these transcription factors are regulated and what determines their expression are unclear. Given that follicular dendritic cells (FDC) closely interact with B cells within the GC, provide survival signal to protect B cells from apoptosis and are essential for the differentiation of GC B cells, we used an in vitro FDC-B-cell co-culture model to explore the role of FDC-B cell interaction and FDC-induced miRNA in the regulation of BCL6 and PRDM-1 expression. In this study 1) we revealed that follicular dendritic cells (FDCs, HK) regulate expression of transcription factor (BCL6, and PRDM1) via cell-cell contact, 2) we showed that FDCs regulate expression of B-cell survival and differentiation-related microRNAs, 3) we demonstrated that microRNAs regulate expression of transcription factors BCl6 and PRDM1 and 4) we documented that follicular dendritic cells regulate expression of transcription factor (BCL6, and PRDM1) through microRNAs and plays an important role in B-differentiation. These studies establish new molecular mechanisms for regulation of BCL6 and PRDM-1. FDC-induce miRNA mediated down- and up-regulation of transcriptional factors may contribute to the phenotype maintenance of GC, and pathogenesis of non-Hodgkin's lymphoma (NHL) by interfering with normal B-cell terminal differentiation. Disclosures: No relevant conflicts of interest to declare.
Matrix Metalloproteinase (MMP)-1 Induces Lung Alveolar Epithelial Cell Migration and Proliferation, Protects from Apoptosis, and Represses Mitochondrial Oxygen Consumption (2013)

Idiopathic pulmonary fibrosis is a devastating lung disorder of unknown etiology. Although its pathogenesis is unclear, considerable evidence supports an important role of aberrantly activated alveolar epithelial cells (AECs), which produce a large variety of mediators, including several matrix metalloproteases (MMPs), which participate in fibroblast activation and lung remodeling. MMP-1 has been shown to be highly expressed in AECs from idiopathic pulmonary fibrosis lungs although its role is unknown. In this study, we explored the role of MMP-1 in several AECs functions. Mouse lung epithelial cells (MLE12) transfected with human Mmp-1 showed significantly increased cell growth and proliferation at 36 and 48 h of culture (p < 0.01). Also, MMP-1 promoted MLE12 cell migration through collagen I, accelerated wound closing, and protected cells from staurosporine- and bleomycin-induced apoptosis compared with mock cells (p < 0.01). MLE12 cells expressing human MMP-1 showed a significant repression of oxygen consumption ratio compared with the cells with the empty vector. As under hypoxic conditions hypoxia-inducible factor-1α (HIF-1α) mediates a transition from oxidative to glycolytic metabolism, we analyzed activation of HIF-1α. Ηigher activation of this factor was detected in MMP-1-transfected cells under normoxia and hypoxia. Likewise, a significant decrease of both total and mitochondrial reactive oxygen species was observed in MMP-1-transfected cells. Paralleling these findings, attenuation of MMP-1 expression by shRNA in A549 (human) AECs markedly reduced proliferation and migration (p < 0.01) and increased the oxygen consumption ratio. These findings indicate that epithelial expression of MMP-1 inhibits mitochondrial function, increases HIF-1α expression, decreases reactive oxygen species production, and contributes to a proliferative, migratory, and anti-apoptotic AEC phenotype.
Convenient synthesis and polymerization of 5,6‐disubstituted dithiophthalides toward soluble poly(isothianaphthene): An initial spectroscopic characterization of the resulting low‐band‐gap polymers (2003)

Abstract A new synthetic procedure toward substituted dithiophthalides, 5,6‐dialkyloxydithiophthalide and 5,6‐dithioalkyldithiophthalide, is presented. 5,6‐Dithiooctyldithiophthalide was obtained from 4,5‐dichlorophthalic acid in an eight‐step reaction with an overall yield of 26%. 5,6‐Dioctyloxydithiophthalide was obtained from 4,5‐dihydroxyphthalic acid dimethyl ester in a seven‐step reaction (overall yield = 15%). Both monomers were polymerized by a thermal and nonoxidative polymerization that resulted in soluble poly(isothianaphthene) derivatives with a band gap of about 1.2 eV. Photoinduced absorption measurements revealed the existence of charged excitations upon illumination. The photoinduced charge generation, combined with the extensive light‐harvesting properties and the easy processability, makes these materials quite promising for photovoltaic applications. © 2003 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 41: 1034–1045, 2003