gebhart/patrepeval huggingface dataset:
EFFECTS OF DRAG-REDUCING POLYMERS ON BLOOD FLOW IN MICROCHANNELS (2006)

Blood-soluble drag-reducing polymers (DRPs) have been shown to produce significant beneficial effects on blood circulation, including an increase in tissue perfusion and tissue oxygenation and a decrease in vascular resistance, when injected in blood at minute concentrations. Elucidation of the mechanisms of the observed DRP effects on blood circulation is extremely important for future clinical applications of these polymers. We studied the effects of DRPs (polyethylene oxide WSR-301 and an aloe derived polysaccharide) on the microflow of red blood cell (RBC) suspensions in small capillary tubes and microchannels to test the hypothesis that DRPs cause a reduction of the near-wall cell-free layer in microvessels attenuating the Fahraeus effect. The development of certain near-wall plasma layers, and thus the potential of DRPs to diminish them, is dependent on capillary diameter. Our studies were performed in capillary tubes ranging in diameter from 200 to 400 microns and a 100 micron microchannel using bovine blood. Reynolds numbers ranged from 10 to 300. Some RBCs were fluorescently labeled with fluorescein isothiocyanate and added to the suspension to directly visualize the effects of DRPs on RBC flow paths in a microchannel. These studies demonstrated that the DRPs promoted movement of RBCs closer to the vessel walls, especially in smaller channels. In vivo, this may lead to a reduction of the near-wall plasma layer, which would facilitate gas transport and potentially promote vasodilation and decrease vascular resistance in the microvessels.
RELATIONSHIP OF OKT3 SENSITIZATION AND VASCULAR REJECTION IN CARDIAC TRANSPLANT PATIENTS RECEIVING OKT3 REJECTION PROPHYLAXIS (1990)

We prospectively and serially monitored plasma levels of OKT3 in 20 patients who were receiving 14- or 21-day rejection prophylaxis with OKT3. We retrospectively compared plasma OKT3 levels with biopsy scores assessed by light microscopy and immunofluorescence, clinical findings, human antimouse antibody (HAMA) production assessed by a blocking assay and by ELISA, and circulating immune complex levels assessed by a flow cytometric Raji cell assay. Using these methods, we evaluated the relationship of OKT3 sensitization, a humorally mediated immune response, to the development of vascular rejection in these patients. We found that 6 of 20 patients had declines in plasma OKT3 levels to less than 50% of their steady-state value before the conclusion of therapy (OKT3 consumption). This fall in plasma OKT3 preceded a significant rise in the CD 3 lymphocyte level by up to 3 days. All 6 patients showed HAMA production by either blocking or ELISA assay (P = less than 0.02) and developed vascular rather than cellular rejection (P = less than 0.01). OKT3 sensitization was significantly more common in patients treated with 21-day rejection prophylaxis (4 of 6 patients, P = less than 0.01). Only 4 of 14 other patients showed vascular rejection; 2 of these 4 also developed HAMA without OKT3 consumption and both had been treated with 21-day rejection prophylaxis with OKT3. None of the 20 patients showed significant levels of circulating immune complexes. This study demonstrates that OKT3 sensitization is strongly associated with vascular rejection. Vascular rejection was usually demonstrated 7 days after OKT3 consumption was seen and was coincident with HAMA production. By contrast, 4 patients without OKT3 sensitization had vascular rejection demonstrable in the early posttransplant period; in such patients, prospective immunofluorescence of biopsies was the only reliable indicator of this rejection type. The higher incidence of vascular rejection in these 20 patients was definitely related to the use of 21-day OKT3 rejection prophylaxis. Overall, 7 of the 12 patients treated with this regimen developed vascular rejection. Allograft and patient survival among patients with vascular rejection was significantly worse than in patients with cellular rejection (P = less than 0.01). Prospective monitoring of patients treated with OKT3 by serial plasma levels and by biopsy immunofluorescence will identify patients at risk for these types of humoral rejection.
Interactive Data Visualization (2010)

Visualization is the process of representing data, information, and knowledge in a visual form to support the tasks of exploration, confirmation, presentation, and understanding. This book is designed as a textbook for students, researchers, analysts, professionals, and designers of visualization techniques, tools, and systems. It covers the full s
Heap/stack guard pages using a wakeup unit (2023)

A method and system for providing a memory access check on a processor including the steps of detecting accesses to a memory device including level-1 cache using a wakeup unit. The method includes invalidating level-1 cache ranges corresponding to a guard page, and configuring a plurality of wakeup address compare (WAC) registers to allow access to selected WAC registers. The method selects one of the plurality of WAC registers, and sets up a WAC register related to the guard page. The method configures the wakeup unit to interrupt on access of the selected WAC register. The method detects access of the memory device using the wakeup unit when a guard page is violated. The method generates an interrupt to the core using the wakeup unit, and determines the source of the interrupt. The method detects the activated WAC registers assigned to the violated guard page, and initiates a response.
Application of a MIC Metallic Flake ASA/PC Weatherable Resin Predictive Engineering Package (2006)

&lt;div class="htmlview paragraph"&gt;The automotive industry continues to strive for mold-in-color (MIC) solutions that can provide metallic flake appearances. These MIC solutions can offer a substantial cost out opportunity while retaining a balance of weathering performance and physical properties. This paper discusses a predictive engineering package used to hide, minimize and eliminate flow lines. Material requirements and the methods used to evaluate flowline reduction and placement for visual inspection criteria are detailed. The Nissan Quest® luggage-rack covers are used to illustrate this application. The paper also explores how evolving predictive packages offer expanding possibilities.&lt;/div&gt;
Design, synthesis, and biological and docking studies of novel epipodophyllotoxin–chalcone hybrids as potential anticancer agents (2014)

Click-chemistry based design and efficient synthesis of podophyllotoxin–chalcone conjugates as potential topoisomerase-II inhibitors towards the development of better anticancer leads.
Finite volume methods for transient modeling of gas pipelines (2018)

Given the increasing importance of multi-energy carrier system modeling, this paper focuses on modeling the dynamics that occur in natural gas transmission lines. In high-pressure pipelines, these dynamics are governed by a set of hyperbolic partial differential equations. Dissipative finite volume discretization schemes are proposed that honor the discrete maximum principle. The convergence of the proposed discretization schemes is investigated and compared with existing methods suggested in the literature for natural gas transmission such as the implicit cell-centered method. High order time discretization methods are also tested and their suitability with respect to the maximum principle is discussed.
Kennedy Space Center Fixation Tube (KFT) (2016)

Experiments performed on the International Space Station (ISS) frequently require the experimental organisms to be preserved until they can be returned to earth for analysis in the appropriate laboratory facility. The Kennedy Fixation Tube (KFT) was developed to allow astronauts to apply fixative, chemical compounds that are often toxic, to biological samples without the use of a glovebox while maintaining three levels of containment (Fig. 1). KFTs have been used over 200 times on-orbit with no leaks of chemical fixative. The KFT is composed of the following elements: a polycarbonate main tube where the fixative is loaded preflight, the sample tube where the plant or other biological specimens is placed during operations, the expansion plug, actuator, and base plug that provides fixative containment (Fig. 2). The main tube is pre-filled with 25 mL of fixative solution prior to flight. When actuated, the specimen contained within the sample tube is immersed with approximately 22 mL (+/- 2 mL) of the fixative solution. The KFT has been demonstrated to maintain its containment at ambient temperatures, 4degC refrigeration and -100 C freezing conditions.
Purification and characterization of smooth and rough lipopolysaccharides from Brucella abortus (1979)

In an attempt to obtain pure and well characterized smooth lipopolysaccharide (S-LPS) and rough lipopolysaccharide (R-LPS), smooth and rough strains of Brucella abortus were extracted by two different modifications of the phenol-water method. S-LPS was obtained in the phenol phase, and R-LPS was obtained in the aqueous phase. Further purification was accomplished by treatment with enzymes, detergents, NaI as a chaotropic agent to separate non-covalently bound contaminants, and by gel filtration. The degree of purity of the molecules was determined by chemical and immunological analysis and by electrophoresis in sodium dodecyl sulfate-polyacrylamide gels. Lipid identification by gas-liquid chromatography showed seven major fatty acids. Palmitic acid accounts for about 50%, stearic acid accounts for about 10%, and hydroxylated fatty acids account for less than 5% of total fatty acids. 2-Keto-3-deoxyoctonate but not heptose was detected in the sugar analysis. Protein was found to be firmly bound to S-LPS but not to R-LPS.
ChemInform Abstract: Studies on 6‐Halo‐ and 6,6‐Dihalopenicillins: The Rearrangement of Methyl 6,6‐Dibromopenicillanate to 1,4‐Thiazepine. (1986)

Abstract Die Aminopenicillanate (I) liefern nach Diazotierung und Halogenierung die Dihalogenpenicillanate (III), MCPBA IV) g oxidiert (III) zu den Sulfoxiden (V), KMnO 4 zu den Sulfonen (VI).
Cache-conscious structure layout (1999)

Hardware trends have produced an increasing disparity between processor speeds and memory access times. While a variety of techniques for tolerating or reducing memory latency have been proposed, these are rarely successful for pointer-manipulating programs.This paper explores a complementary approach that attacks the source (poor reference locality) of the problem rather than its manifestation (memory latency). It demonstrates that careful data organization and layout provides an essential mechanism to improve the cache locality of pointer-manipulating programs and consequently, their performance. It explores two placement techniques--- clustering and coloring ---that improve cache performance by increasing a pointer structure's spatial and temporal locality, and by reducing cache-conflicts.To reduce the cost of applying these techniques, this paper discusses two strategies--- cache-conscious reorganization and cache-conscious allocation ---and describes two semi-automatic tools---ccmorph and ccmalloc---that use these strategies to produce cache-conscious pointer structure layouts. ccmorph is a transparent tree reorganizer that utilizes topology information to cluster and color the structure. ccmalloc is a cache-conscious heap allocator that attempts to co-locate contemporaneously accessed data elements in the same physical cache block. Our evaluations, with microbenchmarks, several small benchmarks, and a couple of large real-world applications, demonstrate that the cache-conscious structure layouts produced by ccmorph and ccmalloc offer large performance benefits---in most cases, significantly outperforming state-of-the-art prefetching.
Design and Optimization of Power Supplies for Wireless Integrated Microsystems. (2008)

10 And the disciples came, and said unto him, Why speakest thou unto them in parables? 11 He answered and said unto them, Because it is given unto you to know the mysteries of the kingdom of heaven, but to them it is not given. 12 For whosoever hath, to him shall be given, and he shall have more abundance: but whosoever hath not, from him shall be taken away even that he hath. 13 Therefore speak I to them in parables: because they seeing see not; and hearing they hear not, neither do they understand. 14 And in them is fulfilled the prophecy of Esaias, which saith, By hearing ye shall hear, and shall not understand; and seeing ye shall see, and shall not perceive: 15 For this people&amp;apos;s heart is waxed gross, and their ears are dull of hearing, and their eyes they have closed; lest at any time they should see with their eyes and hear with their ears, and should understand with their heart, and should be converted, and I should heal them. 16 But blessed are your eyes, for they see: and your ears, for they hear. 17 For verily I say unto you, That many prophets and righteous men have desired to see those things which ye see, and have not seen them; and to hear those things which ye hear, and have not heard them.
Residual Deformity Is the Most Common Reason for Revision Hip Arthroscopy: A Three-dimensional CT Study (2014)

We found marked radiographic evidence of incomplete correction of deformity in patients with residual symptoms compared with patients with successful results with residual deformity present in the large majority of patients (45 of 50 [90%]) undergoing residual FAI surgery. We recommend careful attention to full 3-D resection of impinging structures.
Nucleic Acid Cleavage with a Hyperthermophilic Cas9 from an Unculturable Ignavibacterium (2019)

Abstract CRISPR-Cas9 systems have been effectively harnessed to engineer the genomes of organisms from across the tree of life. Nearly all currently characterized Cas9 proteins are derived from mesophilic bacteria, and canonical Cas9 systems are challenged by applications requiring enhanced stability or elevated temperatures. We discovered IgnaviCas9, a Cas9 protein from a hyperthermophilic Ignavibacterium identified through mini-metagenomic sequencing of samples from a hot spring. IgnaviCas9 is active at temperatures up to 100 °C in vitro , which enables DNA cleavage beyond the 44 °C limit of Streptococcus pyogenes Cas9 (SpyCas9) and the 70 °C limit of both Geobacillus stearothermophilus Cas9 (GeoCas9) and Geobacillus thermodenitrificans T12 Cas9 (ThermoCas9). As a potential application of this enzyme, we demonstrated that IgnaviCas9 can be used in bacterial RNA-seq library preparation to remove unwanted cDNA from 16s ribosomal rRNA (rRNA) without increasing the number of steps, thus underscoring the benefits provided by its exceptional thermostability in improving molecular biology and genomic workflows. Taken together, IgnaviCas9 is an exciting addition to the CRISPR-Cas9 toolbox and expands its temperature range.
Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs (2023)

This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
Electronic transfer of prescription-related information: comparing views of patients, general practitioners, and pharmacists. (2003)

Electronic transfer of prescription-related information is likely to be acceptable to all users, but concerns about patient confidentiality and an extended role for pharmacists in prescription management need to be addressed.
The Grizzly, January 29, 1988 (1988)

Social Changes at Ursinus Become Evident • New Student Center Instituted • Restructuring Plagues Pledging System • Commencement Tradition to Change • Letters: Speak for Outside Graduation; Response to Tuition Increase • Swanson: No Chicken Fillet • Lewis to Present Black Perspective • Notes: Wismer Chimneys Smoked Out; Noon Aerobics Active Again; Chic Sharp Shooters Sought; Air Band Contest Announced • Men's B-ball Win Brings Hopes for National Ranking • Match-Tough Matters Ready for Tourney • Gymnasts Take Bear Classic • Swimmers Stroke Victory in Season Opener • Bears Looking Hot in Winter Track • Chemistry Key for 1st Place Bears • Koffel's Silver Anniversary Made Golden • Shikoda Not Far from Home • Europe Encounter Enraptures Jones • Rock 'N Roll Forum • Robertson's Release Rocks with Rhythm
Robust counterfeit PCB detection exploiting intrinsic trace impedance variations (2015)

The long and distributed supply chain of printed circuit boards (PCBs) makes them vulnerable to different forms of counterfeiting attacks. Existing chip-level integrity validation approaches cannot be readily extended to PCB. In this paper, we address this issue with a novel PCB authentication approach that creates robust, unique signatures from a PCB based on process-induced variations in its trace impedances. The approach comes at virtually zero design and hardware overhead and can be applied to legacy PCBs. Experiments with two sets of commercial PCBs as well as a set of custom designed PCBs show that the proposed approach can obtain unique authentication signature with inter-PCB hamming distance of 47.94% or higher.
A Physiological Model for the Estimation of the Fraction Dose Absorbed in Humans (2004)

A physiologically based model for gastrointestinal transit and absorption in humans is presented. The model can be used to study the dependency of the fraction dose absorbed (F(abs)) of both neutral and ionizable compounds on the two main physicochemical input parameters (the intestinal permeability coefficient (P(int)) and the solubility in the intestinal fluids (S(int))) as well as physiological parameters such as the gastric emptying time and the intestinal transit time. For permeability-limited compounds, the model produces the established sigmoidal dependence between F(abs) and P(int). In case of solubility-limited absorption, the model enables calculation of the critical mass-solubility ratio, which defines the onset of nonlinearity in the response of fraction absorbed to dose. In addition, an analytical equation to calculate the intestinal permeability coefficient based on the compound's membrane affinity and molecular weight was used successfully in combination with the physiologically based pharmacokinetic (PB-PK) model to predict the human fraction dose absorbed of compounds with permeability-limited absorption. Cross-validation demonstrated a root-mean-square prediction error of 7% for passively absorbed compounds.
Sparse emission pattern in spectral blood Doppler (2017)

Spectral Doppler ultrasound imaging allows quantification of blood flow by estimating the velocity distribution of the blood within a range gate on a single image line. In applications, it is desirable to have both brightness mode (B-mode) at high frame rate, to allow the medical doctor to visualize and follow vessel movement, as well as Doppler mode with high spectral resolution of the velocity distribution, so that changes in blood flow can be tracked. In this paper, we propose a slow-time sparse emission pattern of the blood Doppler signal which significantly reduces the number of transmissions sent. For the proposed sampling scheme, we derive the minimal number of Doppler emissions allowing reconstruction of the signal's power spectrum and provide power spectrum recovery techniques that achieve this minimal rate. Using realistic Field II simulations, we show that accurate estimation of blood velocity spectrum can be performed from only 12% of the transmissions required in conventional scanning. Thus, several vessel regions may be investigated while keeping a high frame rate of the B-mode images.
ChemInform Abstract: Nucleoside 3′‐O‐(2‐oxo‐“spiro”‐4.4‐Pentamethylene‐1.3.2‐oxathiaphospholane)s: Monomers for Stereocontrolled Synthesis of Oligo(Nucleoside Phosphorothioate/Phosphate)s. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Educating People with Disabilities (1994)

Accommodating individuals with disabilities in the workplace is a rapidly growing concern. Furthermore, those who are functionally impaired are in a dire need of assistance. In a classroom, the main function of a student is to learn. Learning is facilitated by an instructor's lectures, writings on the board, use of audiovisuals, etc. Generally, it is presumed that students do not have any common functional impairments (visual, auditory, etc.) and, therefore, no special effort is made to accommodate those who may have such impairments. Obviously, the learning of a legally-blind student or one who has impaired hearing, for example, will be compromised if no assistance is provided. Then there are issues such as providing reading materials for the blind (college catalogues, lecture notes, etc., in braille?). What should be done? The purpose of this panel discussion is to, in general, address and discuss the issues involved in educating people with disabilities, particularly those that are not very obvious or visible (ex., wheelchair confinement). How should university campuses resolve this problem in this age of dwindling resources? Sensitive issues, such as “Needs of the many versus the needs of the few?” and “What responsibility do we have to the few that really need such assistance?”, also need to be resolved.
Numerical Modeling and Physical Simulation of Vortex Heat Transfer Enhancement Mechanisms Over Dimpled Reliefs (2010)

The paper presents a comprehensive analysis of conditions for numerical simulation and physical modeling of convective heat transfer in the vicinity of dimpled surface relief. Contradictory results, unreasonable assumptions, and non-justified conclusions are marked. Based on the analysis of physical experiments the correlation between the predictions and measured data is discussed. Detailed numerical study of turbulent air flow and heat transfer in the narrow channel with three types of dimples (spherical, conic and oval) was carried out. Various mathematical and discrete models, including, those based on solving Reynolds-averaged Navier-Stokes equations (RANS/URANS-SST), and also adaptive scale models (SAS-SST) are compared. The influence of flow parameters (Reynolds number) and geometric sizes (dimple diameter, depth, radius of rounding off of an edge, channel width and height) on local and integral characteristics of flow and heat transfer (total heat output and hydraulic losses) is determined. Special attention is given to reorganizing vortex structures and flow regime (with periodic fluctuations) with increasing relative dimple depth and Reynolds number. For the first time the influence of the scale factor of a constant cross-section channel is detailed. Thermal-hydraulic characteristics of various dimpled reliefs are compared, and the advantage of an oval dimple over a spherical one is shown.