gebhart/patrepeval huggingface dataset:
Cardiovascular Disease Risk Factor Responses to a Type 2 Diabetes Care Model Including Nutritional Ketosis at One Year: An Open Label, Non-Randomized, Controlled Study (2018)

Abstract Background Cardiovascular disease (CVD) is a leading cause of death among adults with type 2 diabetes mellitus (T2D). We recently reported that glycemic control in patients with T2D can be significantly improved through a continuous care intervention (CCI) including nutritional ketosis. The purpose of this study was to examine CVD risk factors in this cohort. Methods We investigated CVD risk factors in patients with T2D who participated in a one year open label, non-randomized, controlled study. The CCI group (n = 262) received treatment from a health coach and medical provider. A usual care (UC) group (n = 87) was independently recruited to track customary T2D progression. Circulating biomarkers of cholesterol metabolism and inflammation, blood pressure (BP), carotid intima media thickness (cIMT), multi-factorial risk scores and medication use were examined. Results The CCI group consisted of 262 patients (baseline mean(SD): age 54(8) y, BMI 40.4(8.8) kg/m 2 ). Intention-to-treat analysis (% change) revealed the following at 1-year with P values &lt; 0.0019 indicating statistical significance after adjustment for multiple comparisons: total LDL-particles (LDL-P) (−4.9%, P=0.02), small LDL-P (−20.8%, P=1.2×10 −12 ), LDL-P size (+1.1%, P=6.0×10 −10 ), ApoB (−1.6%, P=0.37), ApoA1 (+9.8%, P&lt;10 −16 ), ApoB/ApoA1 ratio (−9.5%, P=1.9×10 −7 ), triglyceride/HDL-C ratio (−29.1%, P&lt;10 −16 ), large VLDL-P (−38.9%, P=4.2×10 −15 ), and LDL-C (+9.9%, P=4.9×10 −5 ). Additional effects were reductions in blood pressure, high sensitivity C-reactive protein, and white blood cell count (all P&lt;1×10 −7 ) while cIMT was unchanged. The 10-year atherosclerotic cardiovascular disease (ASCVD) risk score decreased −11.9% (P=4.9×10 −5 ). Antihypertensive medication use was discontinued in 11.4 % of CCI participants (P=5.3×10 −5 ). The UC group of 87 patients (baseline mean(SD): age 52(10)y, BMI 36.7(7.2) kg/m 2 ) showed no significant changes. After adjusting for baseline differences when comparing CCI and UC groups, significant improvements for the CCI group included small LDL-P, ApoA1, triglyceride/HDL-C ratio, HDL-C, hs-CRP, and ASCVD score. The CCI group showed a greater rise in LDL-C. Conclusions A continuous care treatment including nutritional ketosis in patients with T2D improved most biomarkers of CVD risk after one year. The increase in LDL-cholesterol appeared limited to the large LDL subfraction. LDL particle size increased, total LDL-P and ApoB were unchanged, and inflammation and blood pressure decreased. Trial registration Clinicaltrials.gov : NCT02519309 . Registered 10 August 2015
열전도성 플라스틱을 적용한 자동차 LED 전조등 방열구조 연구 (2015)

【Since LEDs (light emitting diodes) have many advantages as a light source in vehicle headlamp, such as good reliability, energy and space saving, and flexible headlamp design. On the other hand, the dependence of its performance and life on temperature have great influence on its practical use. In this study, design and fabrication of heat sink for vehicle LED headlamp were performed using thermally-conductive plastics. This study focused on the effective heat sink structure with limited space in the vehicle LED headlamp. We designed two different prototype of heat sink by thermal simulation using SolidWorks program, which had excellent temperature characteristics. The two different prototype of heat sink were fabricated by injection molding with thermally-conductive plastics. The results showed that LED $T_j$ (junction temperature) of sample B (model 1) and sample C (model 1, 2) was below then $165^{\circ}C$ when applying the thermally-conductive plastics in heat sink of vehicle LED headlamp.】
Supplementary Figure 3A-B from NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis (2023)

Supplementary Figure 3A-B from NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis
Immunology in the Clinic Review Series; focus on host responses: T cell responses to herpes simplex viruses (2011)

Herpes virus infections are chronic and co-exist with acquired immune responses that generally prevent severe damage to the host, while allowing periodic shedding of virus and maintenance of its transmission in the community. Herpes simplex viruses type 1 and 2 (HSV-1, HSV-2) are typical in this regard and are representative of the viral subfamily Alphaherpesvirinae, which has a tropism for neuronal and epithelial cells. This review will emphasize recent progress in decoding the physiologically important CD8(+) and CD4(+) T cell responses to HSV in humans. The expanding data set is discussed in the context of the search for an effective HSV vaccine as therapy for existing infections and to prevent new infections.
The interaction of plant polysaccharides with collagen (1993)

Available from British Library Document Supply Centre- DSC:DX181390 / BLDSC - British Library Document Supply Centre
Color science of nanocrystal quantum dots for lighting and displays (2013)

Abstract Colloidal nanocrystals of semiconductor quantum dots (QDs) are gaining prominence among the optoelectronic materials in the photonics industry. Among their many applications, their use in artificial lighting and displays has attracted special attention thanks to their high efficiency and narrow emission band, enabling spectral purity and fine tunability. By employing QDs in color‐conversion LEDs, it is possible to simultaneously accomplish successful color rendition of the illuminated objects together with a good spectral overlap between the emission spectrum of the device and the sensitivity of the human eye, in addition to a warm white color, in contrast to other conventional sources such as incandescent and fluorescent lamps, and phosphor‐based LEDs, which cannot achieve all of these properties at the same time. In this review, we summarize the color science of QDs for lighting and displays, and present the recent developments in QD‐integrated LEDs and display research. First, we start with a general introduction to color science, photometry, and radiometry. After presenting an overview of QDs, we continue with the spectral designs of QD‐integrated white LEDs that have led to efficient lighting for indoor and outdoor applications. Subsequently, we discuss QD color‐conversion LEDs and displays as proof‐of‐concept applications – a new paradigm in artificial lighting and displays. Finally, we conclude with a summary of research opportunities and challenges along with a future outlook.
Analyzing Plant Gene Targeting Outcomes and Conversion Tracts with Nanopore Sequencing (2021)

The high-throughput molecular analysis of gene targeting (GT) events is made technically challenging by the residual presetabce of donor molecules. Large donor molecules restrict primer placement, resulting in long amplicons that cannot be readily analyzed using standard NGS pipelines or qPCR-based approaches such as ddPCR. In plants, removal of excess donor is time and resource intensive, often requiring plant regeneration and weeks to months of effort. Here, we utilized Oxford Nanopore Amplicon Sequencing (ONAS) to bypass the limitations imposed by donor molecules with 1 kb of homology to the target and dissected GT outcomes at three loci in <i>Nicotiana benthamia</i> leaves. We developed a novel bioinformatic pipeline, Phased ANalysis of Genome Editing Amplicons (PANGEA), to reduce the effect of ONAS error on amplicon analysis and captured tens of thousands of somatic plant GT events. Additionally, PANGEA allowed us to collect thousands of GT conversion tracts 5 days after reagent delivery with no selection, revealing that most events utilized tracts less than 100 bp in length when incorporating an 18 bp or 3 bp insertion. These data demonstrate the usefulness of ONAS and PANGEA for plant GT analysis and provide a mechanistic basis for future plant GT optimization.
Agent-Based Modeling of Feeder-Level Electric Vehicle Diffusion for Distribution Planning (2020)

Faced with a rapidly growing electric vehicle (EV) load, distribution planners need a methodology to forecast when and where these loads will likely appear on specific distribution feeders. This paper proposes a new diffusion forecasting approach for residential EV and charging stations using agent-based modeling. Residential EV adoption is treated as a multi-criteria decision making problem modeled via analytic hierarchy process (AHP). The customer adoption model CANE is developed considering customer characteristics including car age, EV attractiveness valued using logistic regression, neighbor influences and customer economics. Distribution feeder topology is combined with property geographic information system (GIS) parcels and household travel survey data to determine geographic and electric locations for EV and charging stations. A Monte Carlo method is utilized to obtain the most likely outcome of the stochastic vehicle decision-making process and perform model calibration. The proposed diffusion forecasting approach is demonstrated using actual distribution feeder data. Using the diffusion results, EV impact on system annual peak, energy, losses, transformer aging and feeder upgrades is evaluated using quasi-static time-series power flow analysis. Case analyses are presented that examine the effect of EV price and charging station placement on EV diffusion and distribution feeder impact.
Superfast Line Spectral Estimation (2018)

A number of recent works have proposed to solve the line spectral estimation problem by applying off-the-grid extensions of sparse estimation techniques. These methods are preferable over classical line spectral estimation algorithms because they inherently estimate the model order. However, they all have computation times that grow at least cubically in the problem size, thus limiting their practical applicability in cases with large dimensions. To alleviate this issue, we propose a low-complexity method for line spectral estimation, which also draws on ideas from sparse estimation. Our method is based on a Bayesian view of the problem. The signal covariance matrix is shown to have Toeplitz structure, allowing superfast Toeplitz inversion to be used. We demonstrate that our method achieves estimation accuracy at least as good as current methods and that it does so while being orders of magnitudes faster.
Removal of Benzene, MTBE and Toluene from Contaminated Waters Using Biochar-Based Liquid Activated Carbon (2022)

Abstract Fuel compounds (BTEX) and fuel additives (MTBE) are pollutants frequently detected in groundwater resources. They may cause serious environmental and health issues and have to be removed from water before use. Ex-situ technologies such as air stripping, advanced oxidation and column adsoroption have been in use for years with different success rates. Recently, more attention has been given to the in-situ remediation methods using liquid/colloidal carbon adsorbents. However, limited studies were found on the use of these adsorbents for the removal of BTEX and MTBE from contaminated waters.Therefore, this study investigates the capacityof using raw biochar-based liquid activated carbon (LAC) and iron-modified biochar-based liquid activated carbon (LAC-Fe) in removing these pollutants. The LAC and Fe-LAC were coated on different host materials (i.e. sand, limestone, 1:1 mixutre of sand and limestone) and granular activated carbon (GAC) under lab-scale batch suspension-adsorption experiment. Results of the study revealed that coating LAC or LAC-Fe on subsurface materials has marginally improved the removal efficiency of MTBE, benzene and toluene but still below that of GAC which reached a removal of 80% for MTBE and more than 90% for BTEX. Results also showed that benzene and toluene were better removed by LAC and LAC-Fe (∼40%) than MTBE (∼20%). There were marginal effects of water chemistry (i.e. salinity and pH) on the removal efficiency of pollutants under the study conditions. The results indicate that more research work is needed to improve the capacity of biochar-based liquidactivated carbonin removing MTBE and BTEX compounds.
Beat-induced fluctuations in auditory cortical beta-band activity: using EEG to measure age-related changes (2014)

People readily extract regularity in rhythmic auditory patterns, enabling prediction of the onset of the next beat. Recent magnetoencephalography (MEG) research suggests that such prediction is reflected by the entrainment of oscillatory networks in the brain to the tempo of the sequence. In particular, induced beta-band oscillatory activity from auditory cortex decreases after each beat onset and rebounds prior to the onset of the next beat across tempi in a predictive manner. The objective of the present study was to examine the development of such oscillatory activity by comparing electroencephalography (EEG) measures of beta-band fluctuations in 7-year-old children to adults. EEG was recorded while participants listened passively to isochronous tone sequences at three tempi (390, 585, and 780 ms for onset-to-onset interval). In adults, induced power in the high beta-band (20-25 Hz) decreased after each tone onset and rebounded prior to the onset of the next tone across tempo conditions, consistent with MEG findings. In children, a similar pattern was measured in the two slower tempo conditions, but was weaker in the fastest condition. The results indicate that the beta-band timing network works similarly in children, although there are age-related changes in consistency and the tempo range over which it operates.
Association between Genetic Polymorphisms in Hepatocyte Nuclear Factor 4α and Type 2 Diabetes in Koreans (2006)

- Abstract - - Abstract - - Abstract - - Abstract - Background: Hepatocyte nuclear factor-4 α (HNF-4 α) is a member of transcription factor network which is essential for the development and function of the beta cell. Furthermore mutations in the HNF-4 α gene have been known to cause maturity-onset diabetes of the young. Therefore we aimed to examine the association between polymorphisms in the HNF-4 α gene and the risk of type 2 diabetes (T2DM) and its related phenotypes in the Korean
4-Phenoxypiperidines:  Potent, Conformationally Restricted, Non-Imidazole Histamine H3 Antagonists (2005)

Two new series of 4-(1-alkyl-piperidin-4-yloxy)-benzonitriles and 4-(1-isopropyl-piperidin-4-yloxy)-benzylamines have been prepared. In vitro activity was determined at the recombinant human H(3) receptor and several members of these new series were found to be potent H(3) antagonists. The present compounds contain a 4-phenoxypiperidine core, which behaves as a conformationally restricted version of the 3-amino-1-propanol moiety common to the many previously described non-imidazole histamine H(3) ligands. One selected member of the new series, 4-[4-(1-isopropyl-piperidin-4-yloxy)-benzyl]-morpholine (13g), was found to be a potent, highly selective H(3) receptor antagonist with in vivo efficacy in a rat EEG model of wakefulness at doses as low as 1 mg/kg sc.
Low-Profile Compact Dual-Band Unit Cell for Polarizing Surfaces Operating in Orthogonal Polarizations (2017)

This communication introduces a novel periodic reflector which provides linear to circular polarization (CP) conversion in two frequency bands. Significantly, the reflector converts a slant 45° linearly polarized wave into two orthogonal CPs over two separate frequency bands while further the unit cell dimensions are maintained below the critical grating lobe limit of half wavelength. Unlike previous designs providing this performance, which are based on linear dipole elements, miniaturization is here achieved by exploiting resonances in both TE and TM polarized waves. The operating principle of the polarizer is discussed and a parametric study is presented to derive design guidelines. A prototype working in the satellite Ku-band has been designed and tested to validate the proposed design. The proposed polarizer can find applications in multiple-beam satellite antenna systems in order to reduce the number of reflector apertures in a single-feed-per-beam configuration.
Spatiotemporal Imaging of Nonequilibrium Current During Impact Ionization Avalanche in n-GaAs (2002)

As a conventional and powerful method to visualize the current density filament, Eberle et al. have shown a visualization technique by measuring the photoluminescence (PL) quench-patterns [3]. By the PL method, Aoki [4-8] has investigated the nucleation process of a current density filament [4] and also the nonlinear dynamics of the filament during the current instability under the magnetic fields in n-GaAs [5, 6]. Very recently, the author has found that the PL pattern image under a short pulsed voltage can be seen as a bright pattern inside the filament or along the filament boundaries in an n-GaAs Corbino disk. [7, 8] The anomalous brightening of the PL intensity observed during the impact ionization avalanche is a quite novel phenomenon because all of the luminescentcenters (neutral donors and bound excitons) have been considered to be completely impact-ionized in the postbreakdown regime. In this paper, the spatiotemporal imaging of the current density filaments in an n-GaAs Corbino disk has been investigated in detail by the PL method. Our purpose is to find the origin of the anomalous brightening of the PL intensity inside the current density filaments.
Tracking chronically recorded single-units in cortically controlled brain machine interfaces (2013)

Multiple single-units recorded from chronically-implanted microelectrode arrays frequently exhibit variability in their spike waveform features and firing characteristics, making it challenging to ascertain the identity of recorded neurons across days. In this study, we present a fast and efficient algorithm that tracks multiple single-units, recorded in a nonhuman primate performing brain control of a robotic arm, across days based on features extracted from units' average waveforms. Furthermore, the algorithm does not require long recording duration to perform the analysis and can be applied at the start of each recording session without requiring the subject to be engaged in a behavioral task. The algorithm achieves a classification accuracy of up to 92% compared to experts' manual tracking.
Dealloying Kinetics of Cu1 − x Ti x on SiO2 Using In Situ X‐Ray Diffraction (1995)

We study the dealloying of Ti from alloy films on oxidized Si substrates in the temperature range of 375 to 490°C and an estimated partial pressure of . Reaction products were determined to be and and possibly at the free surface, and at the interface, according to Rutherford backscattering spectrometry and Auger electron spectroscopy. We found that the Cu lattice parameter varies linearly with Ti concentration, and this variation is independent of temperature in this composition range. As a consequence, we were able to study the dealloying kinetics using in situ x‐ray diffraction by monitoring the time dependence of the Cu lattice parameter. We observe that the reaction kinetics obey a parabolic rate law, i.e., , with a single activation energy of , suggesting that one process governs dealloying kinetics over this temperature range. In addition, we note a pronounced composition dependence, in that the reaction rate increases sharply with increasing Ti concentration. These observations suggest that Ti diffusion in Cu is the rate‐limiting kinetic process for the dealloying reactions in this temperature regime. We model the dealloying reaction and in so doing estimate the diffusion coefficient for Ti in these alloy films.
Quantification of muscle triglyceride synthesis rate requires an adjustment for total triglyceride content (2018)

Intramyocellular triglyceride (imTG) in skeletal muscle plays a significant role in metabolic health, and an infusion of [<sup>13</sup>C<sub>16</sub>]palmitate can be used to quantitate the in vivo fractional synthesis rate (FSR) and absolute synthesis rate (ASR) of imTGs. However, the extramyocellular TG (emTG) pool, unless precisely excised, contaminates the imTG pool, diluting the imTG-bound tracer enrichment and leading to underestimation of FSR. Because of the difficulty of excising the emTGs precisely, it would be advantageous to be able to calculate the imTG synthesis rate without dissecting the emTGs from each sample. Here, we tested the hypothesis that the ASR of total TGs (tTGs), a combination of imTGs and emTGs, calculated as "FSR × tTG pool," reasonably represents the imTG synthesis. Muscle lipid parameters were measured in nine healthy women at 90 and 170 min after the start of [<sup>13</sup>C<sub>16</sub>]palmitate infusion. While the measurements of tTG content, enrichment, and FSR did not correlate (<i>P</i> > 0.05), those of the tTG ASR were significantly correlated (<i>r</i> = 0.947, <i>P</i> < 0.05). These results demonstrate that when imTGs and emTGs are pooled, the resulting underestimation of imTG FSR is balanced by the overestimation of the imTG content. We conclude that imTG metabolism is reflected by the measurement of the tTG ASR.
First total synthesis of (+)-allopumiliotoxin 339A. A practical entry to dendrobatid alkaloids of the allopumiliotoxin class (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFirst total synthesis of (+)-allopumiliotoxin 339A. A practical entry to dendrobatid alkaloids of the allopumiliotoxin classLarry E. Overman, Leslie A. Robinson, and Jeffery ZablockiCite this: J. Am. Chem. Soc. 1992, 114, 1, 368–369Publication Date (Print):January 1, 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/ja00027a061https://doi.org/10.1021/ja00027a061research-articleACS PublicationsRequest reuse permissionsArticle Views588Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
In Situ Observation of Gas Adsorption onto ZIF-8 Using Terahertz Waves (2017)

The adsorption behavior of energy-related gases onto ZIF-8 was investigated using terahertz waves. Comparison of the terahertz transmission spectra of ZIF-8 before and after exposure to the gases revealed that the 2 THz vibrational mode was involved in the gate-opening motion of organic linker molecules. The adsorption properties of each gas were detailed by monitoring the intensities of the 2 THz absorption peak.