gebhart/patrepeval huggingface dataset:
Accumulative Poisoning Attacks on Real-time Data (2021)

Collecting training data from untrusted sources exposes machine learning services to poisoning adversaries, who maliciously manipulate training data to degrade the model accuracy. When trained on offline datasets, poisoning adversaries have to inject the poisoned data in advance before training, and the order of feeding these poisoned batches into the model is stochastic. In contrast, practical systems are more usually trained/fine-tuned on sequentially captured real-time data, in which case poisoning adversaries could dynamically poison each data batch according to the current model state. In this paper, we focus on the real-time settings and propose a new attacking strategy, which affiliates an accumulative phase with poisoning attacks to secretly (i.e., without affecting accuracy) magnify the destructive effect of a (poisoned) trigger batch. By mimicking online learning and federated learning on MNIST and CIFAR-10, we show that model accuracy significantly drops by a single update step on the trigger batch after the accumulative phase. Our work validates that a well-designed but straightforward attacking strategy can dramatically amplify the poisoning effects, with no need to explore complex techniques.
Temperature Dependence of Scintillation Properties of Bright Oxide Scintillators for Well-Logging (2013)

Scintillation characteristics such as the pulse height, energy resolution, and decay time of single crystals of Tl-doped NaI (Tl:NaI), Ce-doped Lu 2 SiO 5 (Ce:LSO), Ce-doped YAlO 3 (Ce:YAP), Ce-doped Gd 3 (Al,Ga) 5 O 12 (Ce:GAGG), Pr-doped Lu 3 Al 5 O 12 (Pr:LuAG), undoped LuAG, and Ce-doped Y 3 Al 5 O 12 (Ce:YAG) transparent ceramics were compared at 25–150 °C to simulate well logging conditions. For increasing temperature, the light output of the scintillators decreased, mostly because of thermal quenching. Among these samples, Pr:LuAG demonstrated the highest scintillation performance at 150 °C.
Optical Patterning in Organic EL Devices (2000)

Fabrication of micropatterned multicolor organic electroluminescent (EL) devices by the &#x201C;photobleaching method&#x201D; is described. In this approach, we take advantage of the instability of organic fluorescent molecules upon photooxidation; that is, organic molecules can be oxidized or bleached by exposure to light in the presence of oxygen. Several types of multicolor devices having a dye-dispersed polymer emitter layer were fabricated. In order to tune the emission color and pattern the device, the polymer emitter layer is exposed to ultraviolet light or visible light after formed by spin coating so that specific dyes are photooxidized and become non-emissive. Due to this photobleaching process, the light-exposed area have different emission colors from the non-exposed area, and, using a fine-patterned photomask, micropatterned multicolor EL devices were successfully fabricated. This photobleaching method is the simplest method for the fabrication of multicolor polymer EL devices and can be applicable to the fabrication of full color displays having arrays of red-green-blue pixels.
Supplementary Tables from Targeting Multiple Myeloma with AMG 424, a Novel Anti-CD38/CD3 Bispecific T-cell–recruiting Antibody Optimized for Cytotoxicity and Cytokine Release (2023)

&lt;p&gt;Tables S1 to S6&lt;/p&gt;
Protective Effects of Oenothera biennis against Hydrogen Peroxide-Induced Oxidative Stress and Cell Death in Skin Keratinocytes (2020)

APOB can protect HaCaT cells from H<sub>2</sub>O<sub>2</sub>-induced DNA damage and cell death by blocking cellular damage related to oxidative stress via a mechanism that affects ROS elimination and by activating the Nrf2/HO-1 signaling pathway.
dc surface flashover mechanism along solids in vacuum based on a collision-ionization model (1988)

Selected experimental results are presented from an extensive experimental investigation of dc prebreakdown and breakdown processes in vacuum along solid insulators made of a variety of alumina ceramics and polymers. The investigations included measurements of predischarge current, x-ray intensity, insulator surface charge density, breakdown behavior as influenced by insulator surface characteristics and insulator profiles, and the analysis of the spectral characteristics associated with insulator surface luminescence. The prebreakdown and breakdown phenomena were found to be strongly influenced by surface microstructure and the chemical state of the insulator surface. The experimentally observed phenomena in our studies strongly point to a new breakdown model based on collision-ionization by electrons of defect sites and/or traps within the dielectric subsurface at the vacuum interface.
Optical modification of cavity-antenna plasmonic nanostructures for brighter and faster single-photon emission (2020)

We establish the fundamental limit for quantum emission enhancement in plasmonic nanostructures combining smaller (cavity) and larger (antenna) modes. We confirm this result numerically and optimize the performance of nanoantennas through controlled photomodification.
A Species-Wide Inventory of NLR Genes and Alleles in Arabidopsis thaliana (2019)

Infectious disease is both a major force of selection in nature and a prime cause of yield loss in agriculture. In plants, disease resistance is often conferred by nucleotide-binding leucine-rich repeat (NLR) proteins, intracellular immune receptors that recognize pathogen proteins and their effects on the host. Consistent with extensive balancing and positive selection, NLRs are encoded by one of the most variable gene families in plants, but the true extent of intraspecific NLR diversity has been unclear. Here, we define a nearly complete species-wide pan-NLRome in Arabidopsis thaliana based on sequence enrichment and long-read sequencing. The pan-NLRome largely saturates with approximately 40 well-chosen wild strains, with half of the pan-NLRome being present in most accessions. We chart NLR architectural diversity, identify new architectures, and quantify selective forces that act on specific NLRs and NLR domains. Our study provides a blueprint for defining pan-NLRomes.
The EXODUS optimizer generator (1987)

This paper presents the design and an initial performance evaluation of the query optimizer generator designed for the EXODUS extensible database system. Algebraic transformation rules are translated into an executable query optimizer, which transforms query trees and selects methods for executing operations according to cost functions associated with the methods. The search strategy avoids exhaustive search and it modifies itself to take advantage of past experience. Computational results show that an optimizer generated for a relational system produces access plans almost as good as those produced by exhaustive search, with the search time cut to a small fraction.
TEM Studies of Disorder-Order Transition in the Acid-Catalyzed Growth of Mesoscopic Silica Thin Films (2001)

Abstract Mesoscopic silica is synthesized by using a self-assembling organic species to direct the structure of an inorganic matrix. It has attracted much interest because of its potential for use in a wide variety of catalysis, separations and nanotechnology applications. The commercial success of this material depends on the ability to simultaneously tailor the channel size and organization. A more complete understanding of the mechanism by which the material forms should lead to improved control over the structure. Small angle X-ray diffraction studies have shown that there is an “induction period” which precedes the observation of well-packed channels in films grown at the air-water interface. However, scattering data alone are unable to establish how the development of order might occur. Direct observation of the evolution is necessary to determine the mechanism by which well-packed, nanometer-sized channels form. Continuous mesoporous silica thin films were grown at the air-water interface.
CSIR: Cellular scheduling with Interest-driven Routing (2013)

CSIR (Cellular Scheduling with Interest-driven Routing) is proposed for the effective dissemination of real-time and elastic traffic in wireless ad-hoc networks. CSIR is a novel cross-layer framework consisting of five components: flow-based priority queuing of packets, distributed interest-based routing, distributed transmission scheduling, a neighbor protocol, and bandwidth reservations. Nodes are scheduled for transmission in coordination with the routes established and the end-to-end delay and bandwidth requirements of the flows. Most of the signaling overhead for active flows is confined to the nodes that are required to maintain them. Results from detailed simulations indicate that, compared to a protocol stack consisting of IEEE 802.11e for channel access, AODV and OLSR for unicast routing, and ODMRP for multicast routing, CSIR attains much better performance in terms of packet delivery and end-to-end delay for elastic and real-time unicast and multicast traffic.
Data from p21-Activated Kinase 1 Is Required for Efficient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model (2023)

&lt;div&gt;Abstract&lt;p&gt;The &lt;i&gt;RAS&lt;/i&gt; genes are the most commonly mutated oncogenes in human cancer and present a particular therapeutic dilemma, as direct targeting of Ras proteins by small molecules has proved difficult. Signaling pathways downstream of Ras, in particular Raf/Mek/Erk and PI3K/Akt/mTOR, are dominated by lipid and protein kinases that provide attractive alternate targets in Ras-driven tumors. As p21-activated kinase 1 (Pak1) has been shown to regulate both these signaling pathways and is itself upregulated in many human cancers, we assessed the role of Pak1 in Ras-driven skin cancer. In human squamous cell carcinoma (SCC), we found a strong positive correlation between advanced stage and grade and &lt;i&gt;PAK1&lt;/i&gt; expression. Using a mouse model of &lt;i&gt;Kras&lt;/i&gt;-driven SCC, we showed that deletion of the mouse &lt;i&gt;Pak1&lt;/i&gt; gene led to markedly decreased tumorigenesis and progression, accompanied by near total loss of Erk and Akt activity. Treatment of &lt;i&gt;Kras&lt;sup&gt;G12D&lt;/sup&gt;&lt;/i&gt; mice with either of two distinct small molecule Pak inhibitors (PF3758309 and FRAX597) caused tumor regression and loss of Erk and Akt activity. Tumor regression was also seen in mice treated with a specific Mek inhibitor, but not with an Akt inhibitor. These findings establish Pak1 as a new target in &lt;i&gt;KRAS&lt;/i&gt;-driven tumors and suggest a mechanism of action through the Erk, but not the Akt, signaling pathway. &lt;i&gt;Cancer Res; 72(22); 5966–75. ©2012 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
PMD Monitoring by Tracking the Chromatic-Dispersion-Insensitive RF Power of the Vestigial Sideband (2004)

We demonstrate a simple technique for polarization-mode-dispersion (PMD) monitoring that is insensitive to chromatic dispersion (CD). By monitoring the extracted radio-frequency clock power from the vestigial sideband, a CD-insensitive PMD feedback signal is realized. For a 10-Gb/s return-to-zero (RZ) system, experimental results show that the fluctuation of the feedback clock power due to CD is reduced from /spl sim/20 to /spl sim/3 dB. In the presence of all-order PMD, the distribution of the clock power is essentially unchanged as the inline CD varies. Simulation results for a 40-Gb/s RZ system are also presented.
Targeted-internalization of NFL-peptide functionalized lipid nanocapsules into human glioblastoma cells (2018)

International audience
"Exonic Disruption Facilitates Antiviral CRISPR-Cas9 Activity for Multistrain HIV-1 Elimination" data files (2021)

These data were generated in order to look at the edits produced by CRISPR treatment for HIV at the gene level. This supplements the publication 10.1016/j.ebiom.2021.103678 The data includes Flow cytometry raw fcs files, sanger traces and results.
Molecular Characterization of a Rare Case of Bilateral Vitreoretinal T Cell Lymphoma through Vitreous Liquid Biopsy (2021)

Vitreoretinal lymphoma (VRL) is an uncommon eye malignancy, and VRLs of T cell origin are rare. They are difficult to treat, and their molecular underpinnings, including actionable genomic alterations, remain to be elucidated. At present, vitreous fluid liquid biopsies represent a valuable VRL sample for molecular analysis to study VRLs. In this study, we report the molecular diagnostic workup of a rare case of bilateral T cell VRL and characterize its genomic landscape, including identification of potentially targetable alterations. Using next-generation sequencing of vitreous-derived DNA with a pan-cancer 126-gene panel, we found a copy number gain of <i>BRAF</i> and copy number loss of tumor suppressor <i>DNMT3A</i>. To the best of our knowledge, this represents the first exploration of the T cell VRL cancer genome and supports vitreous liquid biopsy as a suitable approach for precision oncology treatments.
Polymer/air interface space charge determined by a pressure wave propagation technique (2002)

The application of high DC voltage to a polymer/air insulation system can result in space charges on the interface. The space charges can cause significant distortions of the electric field distribution, which may trigger a surface flashover or breakdown in the insulation system. In the present investigation, an attempt has been made to measure the space charge on a polyester/air and PTFE/air interface by using a pressure wave propagation technique (PWP) under DC voltage.
Toward a New Era in Cancer Treatment: Message from the New Editor-in-Chief (2012)

![Figure][1] 

I am honored for the opportunity to lead the journal and build upon the strong success of the past decade under the founding Editor-in-Chief, Dr. Dan Von Hoff, his Deputy and Senior Editors, and the Editorial Board. Since its launch in late 2001, Molecular Cancer Therapeutics (
Correction: CXCL12γ Promotes Metastatic Castration-Resistant Prostate Cancer by Inducing Cancer Stem Cell and Neuroendocrine Phenotypes (2021)

In the original version of this article (1), there was an error in Fig. Specifically,
Experimental analysis of a 5 kW wide input voltage range three-phase buck+boost power factor corrector (2001)

In this paper the experimental analysis of a three-phase three-switch buck+boost PWM rectifier with unity power factor is discussed. The output voltage and the output current control are realized using a digital signal processor where a modulation scheme is employed which does provide minimum switching losses and minimum input capacitor voltage ripple rms value. The control design which is based on an equivalent DC/DC converter and state-space averaging is discussed briefly. Finally, the efficiency, the power factor, and the total harmonic distortion and the low-frequency harmonics of the mains current are gained in dependency on the output power by measurements on a 5 kW prototype of the system.
The shear coefficient for quartz crystal of rectangular cross section in Timoshenko's beam theory (1996)

In this paper, we derive the shear coefficient K for quartz crystal of rectangular cross section in Timoshenko's beam theory of three-dimensional (3-D) elasticity. The theoretical result gives K as a function of the transformed elastic stiffness constants C/sub 22//sup '/, c/spl circ//sub 44/, C/sub 66/'. For an isotropic material it agrees completely with that derived by G.R. Cowper (1966). In addition, a value of K and its temperature coefficient versus cut angle is calculated so that K has a value of 0.796-0.867 and its temperature coefficient of the first order varies from -15.3/spl times/10/sup -6///spl deg/C to +13.2/spl times/10/sup -6///spl deg/C, when a Z-plate of quartz crystal is rotated with a cut angle /spl theta/ of 0-180/spl deg/ about the x axis. The values of K are then compared with those for isotropic materials obtained by other authors.
Lateralized proteome response to the left and right side neuropathic pain in a rat model (2015)

In this thesis, the detection of global proteomics alteration and changes in neuropeptide distribution caused by neuropathic pain in rat spinal cord tissue was the main focus. Neuropathic pain (NP) is a major clinical syndrome caused by disease or dysfunction of the nervous system and often mediated by neuronal networks in the spinal cord. The estimated prevalence of NP is 6-8% in general population. Only in the United States, the indirect cost associated with chronic pain has been estimated to 100 billion dollars each year and NP substantially contributes to this cost. So far, the underlying mechanisms of NP are not well understood. Proteomics techniques are commonly used in biology system studies, due to its high throughput, capability of unbiased analysis and sensitivity. It builds up a bridge to link genes, peptides, proteins, and the disease. Two proteomic/peptidomic approaches were developed, evaluated and discussed in this thesis. Both of them were further applied in the studies of neuropathic pain. First approach is a quantitative proteomic approach using liquid chromatography combined with Fourier transform mass spectrometry (LC-FTMS), which is developed for quantitative analysis of proteins originated from small central nervous system (CNS) samples. This approach was successfully applied in the study of the rat spinal cord tissue proteome in a neuropathic pain model. Another approach is using matrix assisted laser desorption ionization mass spectrometry (MALDI-MS) for the visualization of the distribution of neuropeptides in rat spinal cord, which in the future will be applied in investigating the ongoing signal transmission under neuropathic pain conditions. Results provided by these two methods are of high importance for the general understanding of the underlying pathophysiological mechanisms and potential identification of new targets for novel treatment of neuropathic pain.
F-37 Macroscopic X-ray Fluorescence Capability for Large-Scale Elemental Mapping (2010)

A non-destructive method of determining segregation of constituent elements over large length-scales is desired. Compositional information to moderate resolution over centimeters will be powerful not only to validate casting models but also to understand large-scale phenomena during solidification. To this end, they have rebuilt their XRF capability in conjunction with IXRF Systems, Inc. (Houston, TX) to accommodate samples that are much larger than those that typically fit into an XRF instrument chamber (up to 70 cm x 70 cm x 25 cm). This system uses a rhodium tube with maximum power of 35 kV and 100 {mu}A, the detector is a liquid nitrogen cooled lithium drifted silicon detector, and the smallest spot size is approximately 0.4 mm. Reference standard specimens will enable quantitative elemental mapping and analysis. Challenges to modifying the equipment are described. Non-uniformities in the Inconel 718 system will be shown and discussed. As another example, segregation of niobium or molybdenum in depleted uranium (DU) castings has been known to occur based on wet chemical anslysis (ICP-MS), but this destructive and time-consuming measurement is not practical for routine inspection of ingots. The U-Nb system is complicated due to overlap of the Nb K-alpha line with the U L-beta. Preliminary quantitative results are included on the distribution of Nb across slices from DU castings with different cooling rates. They foresee this macro-XRF elemental mapping capability to prove invaluable to many in the materials processing industry.
Clocked Domain Wall Logic Using Magnetoelectric Effects (2016)

A new digital device scheme based on the magnetoelectric coupling and automotion of the magnetic domain wall is proposed. A single device is composed of a ferromagnetic wire and two ferroelectric capacitors served as the input and the output. It is shown that with the initialization in the magnetic states, a single device and the corresponding majority gate can realize the NOT, NAND, and NOR functions. Furthermore, the device has the cascadability, input-output isolation, gain, and nonreciprocity. The device concepts are justified by the numerical calculation, including the Landau-Lifshitz-Gilbert equation for the magnetization dynamics, the Landau-Khalatnikov equation for the electric polarization dynamics, and the electrostatic equations for the open-circuit output voltage and the charge sharing process between devices. The energy dissipation is also quantified and shown to be two to three orders of magnitude less than that in spin-torque-driven devices.
Gas-Phase Decomposition Reactions of Tris(dimethylamino)phosphine, -Arsine, and -Stibine Reagents (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGas-Phase Decomposition Reactions of Tris(dimethylamino)phosphine, -Arsine, and -Stibine ReagentsSateria Salim, Chee Kiang Lim, and Klavs F. JensenCite this: Chem. Mater. 1995, 7, 3, 507–516Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/cm00051a011https://doi.org/10.1021/cm00051a011research-articleACS PublicationsRequest reuse permissionsArticle Views423Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
CH4 Activation by Photoexcited Cu2 Molecules (1982)

Abstract The complete manuscript of this communication appears in: Angew. Chem. Suppl. 1982 , 798. DOI: 10.1002/anie.198207980
Evaluation of the 18F-labeled analog of the therapeutic all-D-enantiomeric peptide RD2 for amyloid β imaging (2023)

Positron emission tomography (PET) imaging with radiotracers that bind to fibrillary amyloid β (Aβ) deposits is an important tool for the diagnosis of Alzheimer's disease (AD) and for the recruitment of patients into clinical trials. However, it has been suggested that rather than the fibrillary Aβ deposits, it is smaller, soluble Aβ aggregates that exert a neurotoxic effect and trigger AD pathogenesis. The aim of the current study is to develop a PET probe that is capable of detecting small aggregates and soluble Aβ oligomers for improved diagnosis and therapy monitoring. An <sup>18</sup>F-labeled radioligand was prepared based on the Aβ-binding d-enantiomeric peptide RD2, which is currently being evaluated in clinical trials as a therapeutic agent to dissolve Aβ oligomers. <sup>18</sup>F-labeling was carried out using palladium-catalyzed S-arylation of RD2 with 2-[<sup>18</sup>F]fluoro-5-iodopyridine ([<sup>18</sup>F]FIPy). Specific binding of [<sup>18</sup>F]RD2-cFPy to brain material from transgenic AD (APP/PS1) mice and AD patients was demonstrated with in vitro autoradiography. In vivo uptake and biodistribution of [<sup>18</sup>F]RD2-cFPy were evaluated using PET analyses in wild-type and transgenic APP/PS1 mice. Although brain penetration and brain wash-out kinetics of the radioligand were low, this study provides proof of principle for a PET probe based on a d-enantiomeric peptide binding to soluble Aβ species.