gebhart/patrepeval huggingface dataset:
Expression of helix-loop-helix regulatory genes during differentiation of mouse osteoblastic cells (1992)

Although much is known about the hormonal regulation of osteoblastic cell differentiation, much less is known about the nuclear regulatory molecules that affect this process. We analyzed the expression of several regulatory molecules of the helix-loop-helix (H-L-H) group in primary mouse calvarial cells and in MC3T3-E1 mouse osteoblastic cells in situations representing different degrees of cellular differentiation. H-L-H class regulators are known to participate directly in directing cell fate and differentiation decisions in other mesodermal lineages. Two of the molecules that we studied, Id and E12, have well-established roles in this process. The other, mTwi, the murine homolog of the Drosophila twist gene, is a newly cloned mammalian H-L-H gene. Levels of E12 RNA remained unchanged during differentiation. On the other hand, in both primary osteoblastic cells and MC3T3-E1 cells, the abundance of Id and mTwi declined with cell maturation; mTwi less dramatically than Id. That Id expression is causally related to differentiation is suggested by the finding that MC3T3-E1 cells transfected with an Id-expression plasmid fail to undergo differentiation. We conclude that helix-loop-helix regulatory genes are expressed in mouse osteoblastic cells, where they are likely to participate in differentiation. The E12 gene product is likely to function as a positive modulating factor. In contrast, Id inhibits differentiation, probably by sequestering other H-L-H gene regulators, including E12, in inactive complexes. The precise role of mTwi is more speculative at this time, but the observed pattern of expression is consistent with a role in early and midmesodermal specification that is terminated as cells differentiate.
New Mono‐ and Dimeric Members of the Secalonic Acid Family: Blennolides A–G Isolated from the Fungus Blennoria sp. (2008)

Blennolides A-G (2-8), seven unusual chromanones, were isolated together with secalonic acid B (1) from Blennoria sp., an endophytic fungus from Carpobrotus edulis. This is the first reported isolation of the blennolides 2 and 3 (hemisecalonic acids B and E), the existence of which as the monomeric units of the dimeric secalonic acids had long been postulated. A compound of the proposed structure 4 (beta-diversonolic ester) will need to be revised, as its reported data do not fit those of the established structure of blennolide C (4). Other monomers, the blennolides D-F (5-7) seem to be derived from blennolides A (2) and B (3) by rearrangement of the hydroaromatic ring. The heterodimer 8, composed of the monomeric blennolide A (2) and the rearranged 11-dehydroxy derivative of blennolide E (6), extends the ergochrome family with an ergoxanthin type of skeleton. The structures of the new compounds were elucidated by detailed spectroscopic analysis and further confirmed by an X-ray diffraction study of a single crystal of 2. The absolute configurations were determined by TDDFT calculations of CD spectra, including the solid-state CD/TDDFT approach. Preliminary studies showed strong antifungal and antibacterial activities of these compounds against Microbotryum violaceum and Bacillus megaterium, respectively. They were also active against the alga Chlorella fusca and the bacterium Escherichia coli.
Arrays of anamorphic phase-matched Fresnel elements for diode-to-fiber coupling (1995)

A method for designing microlens arrays that inherently takes into account application requirements and fabrication constraints is presented. Elements with numerical apertures of up to 0.5 have been designed and fabricated by laser beam writing in photoresist and replication in plastic material. In a laser-diode-to-fiber array coupling experiment, an overall optical throughput of 60% was achieved. By means of anamorphic microlens arrays, correction of the laser-diode longitudinal astigmatism and circularization of the image-plane irradiance distribution are demonstrated.
Securing the Storage Data Path with SGX Enclaves (2018)

We explore the use of SGX enclaves as a means to improve the security of handling keys and data in storage systems. We study two main configurations for SGX computations, as they apply to performing data-at-rest encryption in a storage system. The first configuration aims to protect the encryption keys used in the encryption process. The second configuration aims to protect both the encryption keys and the data, thus providing end-to-end security of the entire data path. Our main contribution is an evaluation of the viability of SGX for data-at-rest encryption from a performance perspective and an understanding of the details that go into using enclaves in a performance sensitive environment. Our tests paint a complex picture: On the one hand SGX can indeed achieve high encryption and decryption throughput, comparable to running without SGX. On the other hand, there are many subtleties to achieving such performance and careful design choices and testing are required.
Colloidal Nanocrystals with Molecular Metal Chalcogenide Surface Ligands (2009)

Similar to the way that atoms bond to form molecules and crystalline structures, colloidal nanocrystals can be combined together to form larger assemblies. The properties of these structures are determined by the properties of individual nanocrystals and by their interactions. The insulating nature of organic ligands typically used in nanocrystal synthesis results in very poor interparticle coupling. We found that various molecular metal chalcogenide complexes can serve as convenient ligands for colloidal nanocrystals and nanowires. These ligands can be converted into semiconducting phases upon gentle heat treatment, generating inorganic nanocrystal solids. The utility of the inorganic ligands is demonstrated for model systems, including highly conductive arrays of gold nanocrystals capped with Sn2S6(4-) ions and field-effect transistors on cadmium selenide nanocrystals.
Synthese directe de cu-cha par combinaison d'un complexe de cu et de tetraethylammonium et applications dans la catalyse (2016)

[EN] The present invention relates to a process for the direct synthesis of a material with a CHA zeolite structure in the silicoaluminate form thereof containing copper atoms, which comprises at least the following steps: (i) Preparation of a mixture which contains at least one water source, one copper source, one polyamine, one source of Y tetravalent element, one source of X trivalent element, the tetraethylammonium cation as the only OSDA and one source of alkaline or alkaline earth (A) cations, and wherein the synthesis mixture has the following molar composition: YO 2 : a X 2 O 3 : b OSDA : c A : d H 2 O : e Cu : f polyamine (ii) Crystallization of the mixture obtained in (i) in a reactor; (iii) Recovery of the crystalline material obtained in (ii).
Figure S6 from AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-x<sub>L</sub>, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia (2023)

&lt;p&gt;Figure S6&lt;/p&gt;
Open surgical ablation of ventricular tachycardia: Utility and feasibility of contemporary mapping and ablation tools (2021)

Surgical mapping and ablation of refractory VT with use of contemporary EAM is feasible and effective, particularly among patients with contraindication to percutaneous epicardial access or with another indication for cardiac surgery.
Retinal angiogenesis suppression through small molecule activation of p53 (2020)

Neovascular age-related macular degeneration is a leading cause of irreversible vision loss in the Western world. Cytokine-targeted therapies (such as anti-vascular endothelial growth factor) are effective in treating pathologic ocular angiogenesis, but have not led to a durable effect and often require indefinite treatment. Here, we show that Nutlin-3, a small molecule antagonist of the E3 ubiquitin protein ligase MDM2, inhibited angiogenesis in several model systems. We found that a functional p53 pathway was essential for Nutlin-3–mediated retinal antiangiogenesis and disruption of the p53 transcriptional network abolished the antiangiogenic activity of Nutlin-3. Nutlin-3 did not inhibit established, mature blood vessels in the adult mouse retina, suggesting that only proliferating retinal vessels are sensitive to Nutlin-3. Furthermore, Nutlin-3 inhibited angiogenesis in nonretinal models such as the hind limb ischemia model. Our work demonstrates that Nutlin-3 functions through an antiproliferative pathway with conceivable advantages over existing cytokine-targeted antiangiogenesis therapies.
Structural Investigation of Monoclinic‐Rhombohedral Phase Transition in Na 3 Zr 2 Si 2 PO 12 and Doped NASICON (2015)

Aliovalent doping of the zirconium site in Na 3 Zr 2 Si 2 PO 12 ( NASICON ) was performed with a range of +3 (Al, Y, Fe) and +2 (Co, Ni, Zn) valent cations. The monoclinic‐rhombohedral phase transition was analyzed with high‐temperature in situ X‐ray diffraction, and differential scanning calorimetry ( DSC ). From the lattice parameters extracted at room temperature up to 300°C it was determined that the high‐temperature rhombohedral phase distorts to the low‐temperature monoclinic phase through a shear deformation of the unit cell. DSC confirmed the phase transition and demonstrated that the phase transition temperature was lowered by doping the NASICON structure. Furthermore, the distortion of the lattice was less severe for all doped samples. Ultimately aliovalent substitution for zirconium stabilized the higher symmetry rhombohedral phase of NASICON , with yttrium doping providing the lowest phase transition temperature and the smallest distortion of the lattice through the phase change.
Numerical aperture dependence of damage and supercontinuum generation from femtosecond laser pulses in bulk fused silica (2006)

Competing nonlinear optical effects are involved in the interaction of femtosecond laser pulses with transparent dielectrics: supercontinuum generation and multiphoton-induced bulk damage. We measured the threshold energy for supercontinuum generation and bulk damage in fused silica using numerical apertures (NAs) ranging from 0.01 to 0.65. The threshold for supercontinuum generation exhibits a minimum near 0.05NA and increases quickly above 0.1 NA. For NAs greater than 0.25, we observe no supercontinuum generation. The extent of the blue broadening of the supercontinuum spectrum decreases significantly as the NA is increased from 0.01 to 0.08, showing that weak focusing is important for generating the broadest supercontinuum spectrum. Using a light-scattering technique to detect the onset of bulk damage, we confirmed bulk damage at all NAs studied. At a high NA, the damage threshold is well below the critical power for self-focusing.
Green/Energy‐Efficient Design for D2D (2019)

Abstract Device‐to‐device (D2D) communications, which facilitates direct transmissions between proximate devices, is one of the key enabling technologies for 5G communications. A mobile device commonly carries a limited energy supply, and it is thus critical to develop energy‐efficient D2D communications. This article provides a discourse on how to improve energy efficiency in D2D communications via proper bandwidth and power allocation and how to leverage green energy harvesting and dual‐battery architecture to enhance self‐sustainability of devices. With the introduction of green energy–powered devices, a green relay assignment scheme is used to leverage the green relay devices to assist dual‐hop D2D communications. This article also elicits the important role of mobile edge computing (MEC) in enabling D2D communications in which cloudlets in MEC may provide essential computing resources for the cellular base stations to jointly consider the channel state information among the devices, multihop routing path and bandwidth allocation to efficiently facilitate D2D communications.
Optimal search: A practical interpretation of information-driven sensor management (2012)

We consider the problem of scheduling an agile sensor for performing optimal search for a target. A probability density function is created for representing our knowledge about where the target might be and it is utilized by the proposed sensor management criteria for finding optimal search strategies. The proposed criteria are: an information-driven criterion based on the Kullback-Leibler divergence and a criterion with practical meaning, i.e. performing the sensing action that will yield the maximum probability of detecting the target. It is shown that using the aforementioned criteria result in the same sensing actions when searching for a target, under certain conditions. This result establishes a practical operational justification for using information-driven sensor management for performing search.
High-Performance GaN Vertical Fin Power Transistors on Bulk GaN Substrates (2017)

This letter reports a GaN vertical fin power field-effect-transistor structure with submicron fin-shaped channels on bulk GaN substrates. In this vertical transistor design only n-GaN layers are needed, while no material regrowth or p-GaN layer is required. A combined dry/wet etch was used to get smooth fin vertical sidewalls. The fabricated transistor demonstrated a threshold voltage of 1 V and specific on resistance of 0.36 mΩcm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . By proper electric field engineering, 800 V blocking voltage was achieved at a gate bias of 0 V.
The Power of Large Language Models for Wireless Communication System Development: A Case Study on FPGA Platforms (2023)

Large language models (LLMs) have garnered significant attention across various research disciplines, including the wireless communication community. There have been several heated discussions on the intersection of LLMs and wireless technologies. While recent studies have demonstrated the ability of LLMs to generate hardware description language (HDL) code for simple computation tasks, developing wireless prototypes and products via HDL poses far greater challenges because of the more complex computation tasks involved. In this paper, we aim to address this challenge by investigating the role of LLMs in FPGA-based hardware development for advanced wireless signal processing. We begin by exploring LLM-assisted code refactoring, reuse, and validation, using an open-source software-defined radio (SDR) project as a case study. Through the case study, we find that an LLM assistant can potentially yield substantial productivity gains for researchers and developers. We then examine the feasibility of using LLMs to generate HDL code for advanced wireless signal processing, using the Fast Fourier Transform (FFT) algorithm as an example. This task presents two unique challenges: the scheduling of subtasks within the overall task and the multi-step thinking required to solve certain arithmetic problem within the task. To address these challenges, we employ in-context learning (ICL) and Chain-of-Thought (CoT) prompting techniques, culminating in the successful generation of a 64-point Verilog FFT module. Our results demonstrate the potential of LLMs for generalization and imitation, affirming their usefulness in writing HDL code for wireless communication systems. Overall, this work contributes to understanding the role of LLMs in wireless communication and motivates further exploration of their capabilities.
Data from Protein Kinase Inhibitor H89 Enhances the Activity of <i>Pseudomonas</i> Exotoxin A–Based Immunotoxins (2023)

&lt;div&gt;Abstract&lt;p&gt;HA22 (Moxetumomab pasudotox) is a recombinant immunotoxin (RIT), composed of an anti-CD22 Fv fused to a truncated portion of &lt;i&gt;Pseudomonas&lt;/i&gt; exotoxin A. HA22 is in clinical trials to treat patients with hairy cell leukemia and acute lymphoblastic leukemia (ALL). LMB-11 is an improved variant of HA22 with reduced immunogenicity, has a longer half-life in the blood and high activity &lt;i&gt;in vitro&lt;/i&gt; and in a Burkitt lymphoma model &lt;i&gt;in vivo&lt;/i&gt;. Searching for RIT enhancing combination therapies, we found the protein kinase A inhibitor H89 to enhance LMB-11 and HA22 activity 5- to 10-fold on ALL cell lines and on patient-derived ALL samples. In addition, H89 increased the activity of mesothelin-targeting RITs SS1P (38-fold) and RG7787 (7-fold) against the cervical cancer cell line KB31. Unexpectedly we found that the enhancement by H89 was not because of inhibition of protein kinase A; it was partially recapitulated by inhibition of S6K1, which led to inactivation of its downstream targets rpS6 and GSK3β, resulting in a fall in MCL1 levels. H89 increased the rate of ADP-ribosylation of eukaryotic elongation factor 2, enhancing the arrest of protein synthesis and the reduction of MCL1 in synergy with the RIT. In summary, H89 increased RIT activity by enhancing the two key events: ADP-ribosylation of eEF2 and reduction of MCL1 levels. Significant enhancement was seen with both CD22- and mesothelin-targeting RITs, indicating that H89 might be a potent addition to RIT treatment of CD22-positive ALL and mesothelin-expressing solid tumors. &lt;i&gt;Mol Cancer Ther; 15(5); 1053–62. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
All-optical parallelization for high sampling rate photonic ADC in fully digital radar systems (2010)

Optical samples of RF signals are all-optically parallelized for further processing in low-speed electrical digitizers. This technique enables high-rate sampling with no additional jitter and limited SNR degradation, making this solution suitable for radar systems.
Lachnumon and lachnumol A, new metabolites with nematicidal and antimicrobial activities from the ascomycete Lachnum papyraceum (Karst.) Karst. II. Structural elucidation. (1993)

The structures of two new biologically active chlorinated metabolites isolated from submerged cultures of the ascomycete Lachnum papyraceum have been elucidated by NMR and mass spectroscopy. The compounds, lachnumon (1) and lachnumol A (2), which structurally are related with mycorrhizin A that also is produced by the fungus, contain an unusual chlorinated epoxide group.
Exposing Digital Image Forgeries by Detecting Discrepancies in Motion Blur (2011)

The widespread availability of photo manipulation software has made it unprecedentedly easy to manipulate images for malicious purposes. Image splicing is one such form of tampering. In recent years, researchers have proposed various methods for detecting such splicing. In this paper, we present a novel method of detecting splicing in images, using discrepancies in motion blur. We use motion blur estimation through image gradients in order to detect inconsistencies between the spliced region and the rest of the image. We also develop a new measure to assist in inconsistent region segmentation in images that contain small amounts of motion blur. Experimental results show that our technique provides good segmentation of regions with inconsistent motion blur. We also provide quantitative comparisons with other existing blur-based techniques over a database of images. It is seen that our technique gives significantly better detection results.
Stereochemical effects in some acronycine derivatives (1999)

The stereochemical effects of 18 natural and synthetic 1,2-dihydro-1,2-disubstituted acronycine derivatives are reported. The conformation of the pyran D ring was determined by using J couplings and NOEs derived from 1D 1H and 2D NOESY spectra and molecular mechanics calculations. In the case of the 1-hydroxy derivatives the influence of the solvent, concentration and temperature on the 1H chemical shifts suggests that aggregation phenomena take place in solution through the formation of an intermolecular hydrogen bond. Aggregation in the gas phase was confirmed by electrospray ionization mass Spectra. The assignment of the 13C chemical shifts was made by 2D NMR techniques. A correlation between the relative stereochemistry at C(1) and C(2) on the D ring and the methyl group carbon chemical shifts was established. Copyright © 1999 John Wiley & Sons, Ltd.
AutoTag 'n Search My Photos (2015)

Personal photo collections are large and growing rapidly. Today, it is difficult to search such a photo collection for people who occur in them since it is tedious to manually associate face tags in photos. The key idea is to learn face models for friends and family of the user using tagged photos in a social graph such as Facebook as training examples. These face models are then used to automatically tag photos in the collection, thereby making it more searchable and easier to organize. To illustrate this idea we have developed a Windows app called AutoTag 'n Search My Photos. In this demo paper we describe the architecture, user interaction and controls, and our initial learnings from deploying the app.
A Minimax Method for Sequential Linear Interpolation of Nonlinear Color Transformations (1996)

We propose a minimax technique to extract the optimum grid structure that will minimize the error in the interpolation of multidimensional functions using sequential linear interpolation (SLI). The error criterion we use is the maximum absolute error. We apply this method to the problem of color printer characterization.
Probing the dispersion properties of 1D nanophotonic waveguides with far-field Fourier optics (2008)

Abstract. We present an advanced Fourier space imaging technique to probe guided light in nanophotonic structures with an effective numerical aperture of 2.5. This superresolution technique allows us to successfully investigate the dispersive properties of 1D nanowaveguides such as photonic crystal W1 waveguides, photonic wire, slot waveguides, and couplers.
Supercoherent Quantum Bits (2000)

Real quantum systems couple to their environment and lose their intrinsic quantum nature through the process known as decoherence. Here we present a method for minimizing decoherence by making it energetically unfavorable. We present a Hamiltonian made up solely of two-body interactions between four two-level systems (qubits) which has a two-fold degenerate ground state. This degenerate ground state has the property that any decoherence process acting on an individual physical qubit must supply energy from the bath to the system. Quantum information can be encoded into the degeneracy of the ground state and such coherence-preserving qubits will then be robust to local decoherence at low bath temperatures. We show how this quantum information can be universally manipulated and indicate how this approach may be applied to a quantum dot quantum computer.