gebhart/patrepeval huggingface dataset:
Ligand‐Protected Ultrasmall Pd Nanoclusters Supported on Metal Oxide Surfaces for CO Oxidation: Does the Ligand Activate or Passivate the Pd Nanocatalyst? (2020)

Herein, we report on the synthesis of ultrasmall Pd nanoclusters (∼2 nm) protected by L-cysteine [HOCOCH(NH<sub>2</sub> )CH<sub>2</sub> SH] ligands (Pd<sub>n</sub> (L-Cys)<sub>m</sub> ) and supported on the surfaces of CeO<sub>2</sub> , TiO<sub>2</sub> , Fe<sub>3</sub> O<sub>4</sub> , and ZnO nanoparticles for CO catalytic oxidation. The Pd<sub>n</sub> (L-Cys)<sub>m</sub> nanoclusters supported on the reducible metal oxides CeO<sub>2</sub> , TiO<sub>2</sub> and Fe<sub>3</sub> O<sub>4</sub> exhibit a remarkable catalytic activity towards CO oxidation, significantly higher than the reported Pd nanoparticle catalysts. The high catalytic activity of the ligand-protected clusters Pd<sub>n</sub> (L-Cys)<sub>m</sub> is observed on the three reducible oxides where 100 % CO conversion occurs at 93-110 °C. The high activity is attributed to the ligand-protected Pd nanoclusters where the L-cysteine ligands aid in achieving monodispersity of the Pd clusters by limiting the cluster size to the active sub-2-nm region and decreasing the tendency of the clusters for agglomeration. In the case of the ceria support, a complete removal of the L-cysteine ligands results in connected agglomerated Pd clusters which are less reactive than the ligand-protected clusters. However, for the TiO<sub>2</sub> and Fe<sub>3</sub> O<sub>4</sub> supports, complete removal of the ligands from the Pd<sub>n</sub> (L-Cys)<sub>m</sub> clusters leads to a slight decrease in activity where the T<sub>100%</sub> CO conversion occurs at 99 °C and 107 °C, respectively. The high porosity of the TiO<sub>2</sub> and Fe<sub>3</sub> O<sub>4</sub> supports appears to aid in efficient encapsulation of the bare Pd<sub>n</sub> nanoclusters within the mesoporous pores of the support.
The Diversity of Uses for Cellulose Sulphate Encapsulation (2013)

In this chapter we propose sodium cellulose sulphate (SCS) as a prime candidate for clinical application of encapsulated cells and present data for uses of SCS encapsulation for the direct delivery of therapeutic antibodies and advanced approaches for stem cell therapy. We also provide a simple lab protocol allowing researchers to make capsules at the bench without the need for expensive machinery.
Parametrization of the regular equivalences of the canonical controller and its applications (2007)

We study control problems for linear systems in the behavioral framework. Our focus is a class of regular controllers that are equivalent to the canonical controller. The canonical controller is a particular controller that is guaranteed to be a solution whenever a solution exists. However, it has been shown that in most cases, the canonical controller is not regular. The main result of the paper is a parametrization of all regular controllers that are equivalent to the canonical controller. The parametrization is then used to solve two control problems. The first problem is related to designing a regular controller that uses as few control channels as possible. The second problem is to design a regular controller that satisfies a predefined input-output partitioning constraint. In both problems, based on the parametrization, we present algorithms that does the controller design.
GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats (2021)

Biased ligands that selectively confer activity in one pathway over another are pharmacologically important because biased signaling may reduce on-target side effects and improve drug efficacy. Here, we describe an N-terminal modification in the incretin hormone glucagon-like peptide (GLP-1) that alters the signaling capabilities of the GLP-1 receptor (GLP-1R) by making it G protein biased over internalization but was originally designed to confer DPP-4 resistance and thereby prolong the half-life of GLP-1. Despite similar binding affinity, cAMP production, and calcium mobilization, substitution of a single amino acid (Ala8 to Val8) in the N-terminus of GLP-1(7-36)NH<sub>2</sub> (GLP-1 Val8) severely impaired its ability to internalize GLP-1R compared to endogenous GLP-1. In-depth binding kinetics analyses revealed shorter residence time for GLP-1 Val8 as well as a slower observed association rate. Molecular dynamics (MD) displayed weaker and less interactions of GLP-1 Val8 with GLP-1R, as well as distinct conformational changes in the receptor compared to GLP-1. <i>In vitro</i> validation of the MD, by receptor alanine substitutions, confirmed stronger impairments of GLP-1 Val8-mediated signaling compared to GLP-1. In a perfused rat pancreas, acute stimulation with GLP-1 Val8 resulted in a lower insulin and somatostatin secretion compared to GLP-1. Our study illustrates that profound differences in molecular pharmacological properties, which are essential for the therapeutic targeting of the GLP-1 system, can be induced by subtle changes in the N-terminus of GLP-1. This information could facilitate the development of optimized GLP-1R agonists.
Growth hormone and growth hormone releasing hormone (1989)

Growth hormone (GH) is secreted by the anterior pituitary in a pulsatile fashion. Its secretion is tightly regulated by hypothalamic factors and by feedback from peripheral factors such as serum glucose and fatty acid levels. The hypothalamic input includes the reciprocal secretion of somatostatin and growth hormone releasing hormone (GHRH). Thus, a pulse of GH is mediated by suppression of tonic hypothalamic somatostatin secretion associated with an increase in GHRH secretion. This will not be further discussed but has been reviewed in detail previously (Tannenbaum & Ling, 1984; Thorner et al., 1986). As shown in Figure 1, GH is also regulated by circulating levels of somatomedin C (otherwise known as insulin-like growth factor) which is either produced locally or in the periphery. Thus, somatomedin C inhibits GH secretion at both the pituitary and hypothalamic levels by modulating somatostatin and possibly also GHRH secretion. Another important influence on GH secretion is gonadal steroids. This occurs in both the human and in animals.
Phase 2 trial of dovitinib in Bacillus Calmette-Guerin (BCG) refractory urothelial carcinoma (UC) with tumor FGFR3 mutations or over-expression: Hoosier Cancer Research Network GU12-157. (2016)

4526 Background: FGFR3 aberrations are common in low grade non-muscle invasive bladder cancer (NMIBC) tumors but decrease in frequency in metastatic UC. This multisite single-arm trial assessed the clinical and pharmacodynamic activity of dovitinib (an oral FGFR3/VEGFR2 inhibitor) in a treatment resistant, molecularly enriched NMIBC population. Methods: Patients (pts) with BCG refractory NMIBC despite at least 2 prior intravesical therapy regimens with increased tumor FGFR3 expression by centrally analyzed immunohistochemistry (IHC+) or FGFR3 mutations (Mut+) assessed in a CLIA-certified lab were eligible. Pts received dovitinib 500 mg once daily (5 days on / 2 days off) on q28d cycles. The primary endpoint was 6-month TURBT-confirmed complete response (CR) rate. Results: Between 11/2013 and 10/2014, 13 pts enrolled (10 IHC+ Mut-, 3 IHC+ Mut+). Demographics included: median age 70 years; 85% male; CIS (3 pts), Ta/T1 (8 pts), and Ta/T1 + CIS (2 pts); median prior regimens 3; median time from last treatment 6 months. Pts received a median of 4 dovitinib cycles. Dose reductions were required in 10 pts (77%). Treatment related grade 3/4 events included: fatigue, hypertension, hypertriglyceridemia (2 pts, 15% each); hepatotoxicity, stomatitis, rash (1 pt, 8% each). 6-month complete response rate was 8% (0% in IHC+ Mut-; 33% in IHC+ Mut+). The primary endpoint was not met. One pt remains a CR at 15+ months. One pt (8%) developed muscle-invasion on study. Pharmacodynamically active (94-5812 nM) dovitinib concentrations in urothelial tissue were observed in all 9 PK-evaluable pts. Reductions in pFGFR3 IHC staining were observed post-dovitinib treatment. A concordant urine FGFR3 mutation was noted in 1 of the 3 Mut+ pts. Conclusions: Oral dovitinib consistently achieved biologically active concentrations within the urothelium and demonstrated pharmacodynamic FGFR3 inhibition. Long-term administration of dovitinib was not feasible due to frequent treatment related toxicity. Absent clinical activity in FGFR3 IHC+ Mut- pts suggests that this should not be an entry criterion for future trials targeting FGFR3 in UC. Clinical trial information: NCT01732107.
Data Models in the VO: How Do They Make Code Better? (2004)

Data Models exist in people’s heads. Data modelling consists of making these explicit on paper, so that (a) we can discover if there is more than one important model, and (b) we can develop using the model which has the best impedance match with the targeted community. We contend that there is in fact more than one model relevant to the Virtual Observatory (VO), and that while the VOTable model is a valuable fit to the archivists’ model of data, it may be a poor match for many users or (much the same thing) for the software written to service the sort of end-user astronomical applications which the VO targets. We will also review some of the various modelling languages available. 1. Language, models and usability In linguistics, the well-known Sapir-Whorf hypothesis claims that the way we conceive of the world depends on the language we use to describe it. This means that the language we use affects what we can think; and conversely, if we wish to have and manipulate a thought, we must find some language to express it. All this talk of languages matters to us, since when we create software systems, we are generally creating a ‘language’ – in a user-interface, an API or a protocol – which users must employ to interact with the underlying system, be it an application, a library, or a remote service. The user, the language and the system each have a model associated with them (see Figure 1), and if there is a good three-way match between the models, then the user’s interactions with the system will be straightforward and generally error-free. If there is a mismatch, they will not. This is not just a matter of user-interface design; if the ‘user’ is a programmer using an API or protocol, then this three-way match will help them write correct code faster, and help produce an application which will be usable by its eventual mouse-wielding audience. In some cases this match is reasonably obvious (think of the web and either HTML or HTTP); in other cases more work is involved (Unix shell language is tightly bound to the underlying system, but it takes effort for the user to Alternate affiliations: NG, University of Glasgow ; DSB, University of Central Lancashire ; PWD, University of Durham ; MBT, University of Bristol
Therapy makeup improves quality of life of patients with skin diseases – covering foundations created by integration of medical and beauty care for severe skin color problems (2009)

IFSCC Magazine , 11 (2008) (1) 11–18 In collaboration with medical institutions, we have been providing makeup guidance to people with facial skin color problems under the name »therapy makeup«. The aim of therapy makeup is to reduce the anxiety and tension associated with the appearance of people with skin color problems and to provide psychological support, thereby helping them live more normal lives. Ota's nevus (blue birthmarks) and port‐wine stain (red birthmarks) the leading causes of abnormal skin coloration. We have already developed covering foundations for Ota's nevus and port‐wine stain using a light‐filtering technology. Another common cause of abnormal skin coloration is vitiligo (white patches). Vitiligo cannot be adequately covered by conventional cosmetic foundations. Therefore, we developed a new covering foundation for vitiligo based on optical characteristics. Moreover, the effects of makeup on the psychology of patients with vitiligo were objectively evaluated using psychometrically established quality of life indices. It was demonstrated that makeup helped to alleviate the psychological anxiety and tension of patients, resulting in improvement of social relationships and self‐esteem. The integration of medical care and beauty care enables therapy makeup to improve quality of life of patients with skin color disorders.
Quantum Ghost Imaging without an Optical Delay Line for Non-Destructive Imaging of Water Content in Plants (2023)

By using correlations between spatially entangled photons, Quantum Ghost Imaging allows for imaging plant water content without influencing light-dependent plant processes. A proprietary spatially and temporally resolved camera negates the need for optical delay lines.
Protein-Based Multiplex Assays: Mock Presubmissions to the US Food and Drug Administration (2009)

Abstract As a part of ongoing efforts of the NCI-FDA Interagency Oncology Task Force subcommittee on molecular diagnostics, members of the Clinical Proteomic Technology Assessment for Cancer program of the National Cancer Institute have submitted 2 protein-based multiplex assay descriptions to the Office of In Vitro Diagnostic Device Evaluation and Safety, US Food and Drug Administration. The objective was to evaluate the analytical measurement criteria and studies needed to validate protein-based multiplex assays. Each submission described a different protein-based platform: a multiplex immunoaffinity mass spectrometry platform for protein quantification, and an immunological array platform quantifying glycoprotein isoforms. Submissions provided a mutually beneficial way for members of the proteomics and regulatory communities to identify the analytical issues that the field should address when developing protein-based multiplex clinical assays.
Control of light polarization using spin-injected opto-electronic devices with vertical geometries (2014)

International audience
Studies of correlations between D and mesons in high energy photoproduction (2003)

Studies of DD̄ correlations for a large sample of events containing fully and partially reconstructed pairs of charmed D mesons recorded by the Fermilab photoproduction experiment FOCUS (FNAL-E831) are presented. Correlations between D and D̄ mesons are used to study heavy quark production dynamics. We present results for fully and partially reconstructed charm pairs and comparisons to a recent version of PYTHIA with default parameter settings. We also comment on the production of ψ (3770) in our data.
A neural tree network for phoneme classification with experiments on the TIMIT database (1992)

Neural tree networks (NTNs) provide an efficient technique for pattern classification. They combine the concept of decision trees with neural networks (NNs). An efficient algorithm is presented for growing NTNs through analysis of the relative confusion among the classes. The NTN is tested on 36 phonemes extracted from the TIMIT database. Results show that this implementation with five hidden neurons at each tree node grows to 8 levels and scores 58.6% correct classification, as opposed to a NN with best performance of 52.4% using 130 hidden neurons. In addition to advantages in computational complexity and recognition performance, the NTN is found to provide important phonemic correlations which are known to exist in the human auditory system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
An in vivo animal model of gene therapy for leukocyte adhesion deficiency. (1991)

Leukocyte adhesion deficiency (LAD) is an inherited disorder of leukocyte function that is caused by defects in the CD18 gene and is associated with diminished cell surface expression of CD11/CD18 proteins. We have developed an in vivo model for gene therapy of LAD. Recombinant retroviruses were used to transduce a functional human CD18 gene into murine bone marrow cells which were transplanted into lethally irradiated syngeneic recipients. A reliable flow cytometric assay for hu- man CD18 in transplant recipients was developed based on: (a) the availability of human specific CD18 monoclonal antibodies and (b) the observation that human CD18 can form chimeric heterodimers with murine CD11a on the cell surface. Human CD18 was detected on leukocytes in a substantial number of transplant recipients for at least 6 mo suggesting that the gene had been transduced into stem cells. Expression was demonstrated in several lineages of a variety of hematopoietic tissues, but was consistently highest and most frequent in granulocytes. Murine granulocytes demonstrated appropriate posttranscrip- tional regulation of human CD18 in response to activation of protein kinase C. No apparent untoward effects of human CD18 expression were noted in transplant recipients. These studies suggest a specific strategy for LAD gene therapy that may be effective and safe. (
ChemInform Abstract: Chemistry of Enoxysilacyclobutanes: Highly Selective Uncatalyzed Aldol Additions. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Perturbação de hiperactividade e défice de atenção em adultos: implicações médico-legais. (2011)

Attention-deficit hyperactivity disorder (ADHD) in adults has been associated to a higher probability of problems with justice. Studies in prison populations disclosed higher prevalence of this disturbance. ADHD association with personality disorders and higher substance abuse could partially help in the explanation of this phenomenon. Based in a literature review, the authors present a reflection on the possible implications of the ADHD diagnosis to Forensic Medicine. After a brief review of the clinical aspects, epidemiology, etiology and nosology of ADHD, its repercussions in the sphere of justice are analysed, namely the prevalence of associated criminality, risk factors and the co-morbidity with personality disorders and substance abuse. These elements are used as a base to the discussion of the results and to a subsequent reflection on the question of (in)imputability related with this disorder.
Two-photon spectroscopy of the F 1Πg and f 3Πg states of molecular fluorine (1992)

We report what is to our knowledge the first two-photon excitation spectroscopy of molecular fluorine. The F 1Πg and f 3Πg states are excited with two photons in the range of 206–212 nm. Detection is through vacuum ultraviolet (VUV) fluorescence or ionization. Measurement of the fluorescence spectrum with a VUV spectrometer indicates that the VUV fluorescence occurs on the 157 nm F2 laser transition frequency. Using our spectra and the data of Porter [J. Chem. Phys. 48, 2071 (1968)] we report improved spectroscopic constants for vibrational levels in the F, f, and I 1Σu+ states.
Surface Immobilization of Anti-VEGF Peptide on SPIONs for Antiangiogenic and Targeted Delivery of Paclitaxel in Non-Small-Cell Lung Carcinoma (2023)

A design has been established for the surface decoration of superparamagnetic iron oxide nanoparticles (SPIONs) with anti-vascular endothelial growth factor peptide, HRH, to formulate a targeted paclitaxel (PTX) delivery nanosystem with notable tumor targetability and antiangiogenic activity. The design methodology included (i) tandem surface functionalization <i>via</i> coupling reactions, (ii) pertinent physicochemical characterization, (iii) <i>in vitro</i> assessment of drug release, anti-proliferative activity, and quantification of vascular endothelial growth factor A (VEGF-A) levels, and (iv) <i>in vivo</i> testing using a lung tumor xenograft mouse model. Formulated CLA-coated PTX-SPIONs@HRH depicted a size and surface charge of 108.5 ± 3.5 nm and -30.4 ± 2.3 mV, respectively, and a quasi-spherical shape relative to pristine SPIONs. Fourier transform infrared (FTIR) analysis and estimation of free carboxylic groups supported the preparation of the CLA-coated PTX-SPIONs@HRH. CLA-coated PTX-SPIONs@HRH exhibited high PTX loading efficiency (98.5%) and sustained release <i>in vitro</i>, with a marked dose dependent anti-proliferative activity in A549 lung adenocarcinoma cells, complimented by an enhanced cellular uptake. CLA-coated PTX-SPIONs@HRH significantly reduced secretion levels of VEGF-A in human dermal microvascular endothelial cells from 46.9 to 35.6 pg/mL compared to untreated control. A 76.6% tumor regression was recorded in a lung tumor xenograft mouse model following intervention with CLA-coated PTX-SPIONs@HRH, demonstrating tumor targetability and angiogenesis inhibition. CLA-coated PTX-SPIONs@HRH enhanced the half-life of PTX by almost 2-folds and demonstrated a prolonged PTX plasma circulation time from a subcutaneous injection (SC). Thus, it is suggested that CLA-coated PTX-SPIONs@HRH could provide a potential effective treatment modality for non-small-cell lung carcinoma as a nanomedicine.
TER: A Robot for Remote Ultrasonic Examination: Experimental Evaluations (2008)

This chapter: o Motivates the clinical use of robotic tele-echography o Introduces the TER system o Describes technical and clinical evaluations performed with TER
The marmoset as a model system for studying voluntary motor control (2016)

The common marmoset has recently gained interest as an animal model for systems and behavioral neuroscience. This is due in part to the advent of transgenic marmosets, which affords the possibility of combining genetic manipulations with physiological recording and behavioral monitoring to study neural systems. In this review, they will argue that the marmoset provides a unique opportunity to study the neural basis of voluntary motor control from an integrative perspective. First, as an intermediate animal model, the marmoset represents an important bridge in motor system function between other primates, including humans, and rodents. Second, due to the marmoset's small brain size and lissencephalic cortex, novel electrophysiological and optical recording technologies will allow an integrative study of cortical function at multiple spatial scales beyond that afforded by other non-human primate models. Finally, as a primate expressing an ancestral state of corticospinal organization, the marmoset offers the possibility of understanding the integrative function of cortical and spinal interneuron circuitry in isolation of more recent corticomotoneuronal elaborations. If the potential of the marmoset as a model species is to be realized, they will need to learn to work with their natural behavioral repertoire. They have concluded by considering practical aspects of studying motor systems with marmosets. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 77: 273-285, 2017.
Selective Deposition of Gold Nanoparticles on SiO2/Si Nanowires for Molecule Detection (2005)

The selective deposition of gold nanoparticles on the surface of N-(2-Aminoethyl)-3-aminopropyl-trimethoxysilane (AEAPTMS)-pretreated silicon nanowire (SiNW)s for molecule detection was demonstrated. The SiNWs were fabricated by scanning probe lithography (SPL) and tetramethyl ammonium hydroxide (TMAH) wet etching. The width and height of the SiNWs were 60 nm and 10 nm, respectively. The gold nanoparticles were synthesized by the chemical reduction method. The electronic properties of the SiNWs in response to the binding of different molecules on the surface of the SiNWs subsequently were discussed. A dynamic observation of the change in conductance was conducted to monitor the reaction between gold nanoparticles and the AEAPTMS-pretreated surface of the SiNWs. The reaction of gold nanoparticles on the surface of the SiNWs took about 750 s before conductance saturation. Finally, an engineered enzyme, KSI-126C, with a thiol terminal was designed to bind with the gold nanoparticles on the surface of the SiNWs. Shifts in turn-on voltage in I – V ds characteristics have clearly been observed after the binding of molecules and gold nanoparticles.