gebhart/patrepeval huggingface dataset:
Modification of Chitin Particles with Ionic Liquids Containing Ethyl Substituent in a Cation (2017)

Chitin cannot be dissolved in conventional solvents due to the strong inter- and intrasheet network of hydrogen bonds and the large number of crystalline regions. Some ionic liquids (ILs) have been suggested in the literature as possible solvents for chitin. Seven of them, all having an ethyl group as substituent in the cationic ring, have been tested in this work: [Emim][Cl], [Emim][Br], [Emim][I], [Emim][OAc], [Emim][Lact], [Epyr][I], and [EMS][BFSI]. Chitin was insoluble in [EMS][BFSI] while for all other ILs solubility was limited due to high viscosity of solutions and equilibria have not been reached. Changes in physical structure, particle size distribution, and crystallinity of recovered chitin depended on ionic liquid used. Increase in porosity was observed for chitin treated with [Emim][Cl], [Emim][I], [Emim][Br], and [Emim][Lact]; changes in particle size distribution were observed for [Emim][AcOH] and [EMS][BFSI]; increase in crystallinity was noticed for chitin treated with [Epyr][I] while decrease in crystallinity for [Emim][I] was noticed. All tested ionic liquids were reused four times and changes in FTIR spectra could be observed for each IL.
Low-k spacers for advanced low power CMOS devices with reduced parasitic capacitances (2008)

Integration of low-dielectric constant SiCOH dielectrics (k~3) adjacent to gate stacks is demonstrated using 65 nm technology. Substantial reductions in parasitic capacitances are achieved through reductions in the outer fringe component of the overlap capacitance and the capacitance between the gate stack and metal contacts. These results are consistent with modeling. Although this is demonstrated with 65 nm devices, low-k spacers can cut active power consumption and have the potential to improve performance through reductions in parasitic capacitances which will be of greater importance for future technology nodes.
Complexation of Fatty Acids and Fatty Acid‐CoAs with Synthetic O‐Methylated Polysaccharides (2007)

An experimentally simple, but highly reproducible and reliable method has been developed to follow the complexation event of fatty acid (FA) and FA-CoA with polysaccharides. This method was based on the recent discovery of the unique blue-shifted UV absorption associated with the aggregation of tetraenoic fatty acids (TE-FAs) in aqueous solution. Complexation was monitored by recording the intensity of UV absorption at 250 nm ([free TE-FA]) and 303 nm ([complexed TE-FA]), and the K aggregate of C(20) t,t,t,t-TE-FA exhibited the ideal property for this purpose. Synthetic 3-O-methyl-D-mannose- and 6-O-methyl-D-glucose-containing lipopolysaccharides were found to exhibit a broad range of the binding affinities with C(20) t,t,t,t-TE-FAs as well as saturated FAs/FA-CoAs.
Best-Response Dynamics in Continuous Potential Games: Non-Convergence to Saddle Points (2018)

The paper studies properties of best-response (BR) dynamics in potential games with continuous action sets. It is known that BR dynamics converge to the set of Nash equilibria (NE) in potential games. The set of NE in potential games is composed of local maximizers and saddle points of the potential function. The paper studies non-convergence of BR dynamics to saddle points of the potential function. Under relatively mild assumptions it is shown that BR dynamics may only converge to an interior saddle-point from a measure-zero set of initial conditions. This provides a weak stable manifold theorem in this context.
Reliability of Silicone and Epoxy Resin Encapsulated Power Modules in HV-H3TRB tests with Thin-Resin coated Dice (2022)

Soft silicone gels, as the standard potting materials for power electronic modules, provide little protection against water ingress and thus cannot protect the semiconductors inside the module from corrosion and edge termination breakdown. A novel vacuum assisted potting process employing an epoxy potting material and a thin-resin coat on the semiconductor should provide a significantly improved protection against water absorption indicated degradation. For validation, test modules were built up and tested in an HV-H3TRB environment.
H7N9 influenza split vaccine with SWE oil-in-water adjuvant greatly enhances cross-reactive humoral immunity and protection against severe pneumonia in ferrets (2020)

Until universal influenza vaccines become available, pandemic preparedness should include developing classical vaccines against potential pandemic influenza subtypes. We here show that addition of SWE adjuvant, a squalene-in-water emulsion, to H7N9 split influenza vaccine clearly enhanced functional antibody responses in ferrets. These were cross-reactive against H7N9 strains from different lineages and newly emerged H7N9 variants. Both vaccine formulations protected in almost all cases against severe pneumonia induced by intratracheal infection of ferrets with H7N9 influenza; however, the SWE adjuvant enhanced protection against virus replication and disease. Correlation analysis and curve fitting showed that both VN- and NI-titers were better predictors for protection than HI-titers. Moreover, we show that novel algorithms can assist in better interpretation of large data sets generated in preclinical studies. Cluster analysis showed that the adjuvanted vaccine results in robust immunity and protection, whereas the response to the non-adjuvanted vaccine is heterogeneous, such that the protection balance may be more easily tipped toward severe disease. Finally, cluster analysis indicated that the dose-sparing capacity of the adjuvant is at least a factor six, which greatly increases vaccine availability in a pandemic situation.
Convex Biclustering (2016)

In the biclustering problem, we seek to simultaneously group observations and features. While biclustering has applications in a wide array of domains, ranging from text mining to collaborative filtering, the problem of identifying structure in high-dimensional genomic data motivates this work. In this context, biclustering enables us to identify subsets of genes that are co-expressed only within a subset of experimental conditions. We present a convex formulation of the biclustering problem that possesses a unique global minimizer and an iterative algorithm, COBRA, that is guaranteed to identify it. Our approach generates an entire solution path of possible biclusters as a single tuning parameter is varied. We also show how to reduce the problem of selecting this tuning parameter to solving a trivial modification of the convex biclustering problem. The key contributions of our work are its simplicity, interpretability, and algorithmic guarantees-features that arguably are lacking in the current alternative algorithms. We demonstrate the advantages of our approach, which includes stably and reproducibly identifying biclusterings, on simulated and real microarray data.
[Evaluation of a new technique of extracorporeal perfusion of the swine liver on a swine-primate model]. (1996)

With the increasing success of liver transplantation there is an urgent need for developing an artificial liver support system to be used in patients with liver failure. An extracorporeal porcine liver perfusion machine was successfully tested in animals with experimental liver failure. Livers were flushed, removed from 35 kg pigs and placed in a heated sterile cassette. The portal vein and the hepatic artery of the graft were connected to the arterial system of the animals. The perfusion pressure of the hepatic artery was regulated via a pressure-flow computerized feed-back device. The venous flow was reinfused from the hepatic veins of the graft to the jugular vein of the animals. The experimental work consisted in two steps: 1. evaluation of clinical and biological consequences of liver perfusion in healthy animals (Group A = pigs, n = 3; group B = primates, n = 3); 2. evaluation of the efficiency of the liver perfusion in animals with ischemic liver failure (Groupe D = pigs, n = 6). The control group (Group C = pigs, n = 7) consisted of pigs with ischemic liver failure without hepatic support. No major clinical or biological adverse effects are reported in groups A and B excepted a thrombocytmia and a marked increase in serum transaminases levels in group B. Liver function as assessed by the bile flow was good in both groups. Comatose pigs with ischemic hepatic failure (group D) recovered a subnormal neurological status in five out of six cases. Serum ammoniemia level were significantly decreased (from 1076 +/- 163 to 255 +/- 32 umol/l). A decrease in serum bilirubine levels and an improvement in the coagulation profile were observed in the perfused animals. Pigs and primates tolerated the perfusion procedure well and beneficial effects were observed in perfused pigs with experimental liver failure.
A model for structured document retrieval : empirical investigations (1997)

Documents often display a structure, e.g., several sections, each with several subsections and so on. Taking into account the structure of a document allows the retrieval process to focus on those parts of the document that are most relevant to an information need. In previous work, we developed a model for the representation and the retrieval of structured documents. This paper reports the first experimental study of the effectiveness and applicability of the model. 1 Introduction In traditional information retrieval (IR), a document is considered as an atomic entity that is represented and retrieved as a whole by the system, and is presented to the user as a query result. Documents, then, constitute the basic information units on which IR systems are based. However, documents often display a structure, for example determined by the author. For instance, a document may have several sections, each with several sub-sections and so on. With a structured document, the representable...
Biosynthesis of vitamin B12: the preparative multi-enzyme synthesis of precorrin-3A and 20-methylsirohydrochlorin (a 2,7,20-trimethylisobacteriochlorin) (1996)

The Bacillus subtilis genes hemB, hemC and hemD, encoding respectively the enzymes porphobilinogen synthase, hydroxymethylbilane synthase and uroporphyrinogen III synthase, have been expressed in Escherichia coli using a single plasmid construct. An enzyme preparation from this source converts 5-aminolaevulinic acid (ALA) preparatively and in high yield into uroporphyrinogen III. The Pseudomonas denitrificans genes cobA and cobI, encoding respectively the enzymes S-adenosyl-L-methionine:uroporphyrinogen III methyltransferase (SUMT) and S-adenosyl-L-methionine:precorrin-2 methyltransferase (SP2MT), were also expressed in E. coli. When SUMT was combined with the coupled-enzyme system that produces uroporphyrinogen III, precorrin-2 was synthesized from ALA, and when SP2MT was also added the product from the coupling of five enzymes was precorrin-3A. Both of these products are precursors of vitamin B12, and they can be used directly for biosynthetic experiments or isolated as their didehydro octamethyl esters in > 40% overall yield. The enzyme system which produces precorrin-3A is sufficiently stable to allow long incubations on a large scale, affording substantial quantities (15-20 mg) of product.
Cellular uncoupling can unmask dispersion of action potential duration in ventricular myocardium. A computer modeling study. (1989)

Although slow conduction is a requirement for the preparation of sustained reentry, it alone is not sufficient for the initiation of reentry. Additionally, unidirectional block and recovery of excitability distal to the site of block must occur. Thus, a comprehensive description of the electrophysiological determinants of reentry must explain both slow conduction and unidirectional block. Although there is a growing body of research exploring the influence of axial resistivity and anisotropy on slow conduction, somewhat less is known about the relation of axial resistivity to spatial dispersion of action potential duration, a condition favorable to the development of unidirectional block. We hypothesized that when cells are well coupled, local differences in intrinsic action potential duration are not evident and that, as axial resistivity increases, local variation in action potential duration becomes manifest. We tested this hypothesis in a numerical model of electrical propagation in a grid of resistively coupled ionic current sources simulating a sheet of ventricular myocardium. Spatial dispersion of intrinsic action potential duration was simulated by varying the magnitude of the fully activated slow inward conductance in Beeler-Reuter membrane ionic kinetics. By then altering coupling resistance, we showed that dispersion of manifest action potential duration is masked in the setting of normal low-resistance cellular coupling and unmasked by increased axial resistance. When nonuniform anisotropy was simulated, dramatic pacing-site-dependent changes in both the pattern of activation and dispersion of action potential duration were noted. These findings may be important in understanding the mechanism of reentrant tachycardia initiation in the border zone of chronic, healed myocardial infarctions where evidence suggests that abnormal cellular coupling is the predominant electrophysiological derangement. In this study, we have shown, using a detailed ionic current-based model of cardiac electrical propagation, that changes in axial resistivity can modulate how spatial dispersion of intrinsic action potential duration is manifest.
Toward a Framework for Internet Forensic Analysis (2004)

The world of network security is an arms race where attackers constantly change the signatures of their attacks to avoid detection. Aiding the white-hats in this race is one fundamental invariant across all network attacks (present and future): for the attack to progress there must be communication among attacker, the associated set of compromised hosts and the victim(s), and this communication is visible to the network. We argue that the Internet architecture should be extended to include auditing mechanisms that enable the forensic analysis of network data, with a goal of identifying the true originator of each attack --- even if the attacker recruits innocent hosts as zombies or stepping stones to propagate the attack. In this paper we outline an approach to the problem of Attacker Identification and Attack Reconstruction, describe the challenges involved, and explain our efforts that show the promise of this approach.
Large-Scale Modeling and DR Control of Electric Water Heaters With Energy Star and CTA-2045 Control Types in Distribution Power Systems (2022)

This article proposes a generalized energy storage model for battery energy storage systems, electric water heaters (EWH), and heating, ventilation, and air-conditioning (HVAC) systems to enable demand response control complying to Energy Star and CTA-2045 standards. The demand response control has been implemented in the DER integration testbed, which was originally developed by Electric Power Research Institute, to demonstrate that the “energy content” and “energy take” for BESS and EWH with mixing valve technology are comparable for typical residential ratings. A distribution power system was modeled using the modified IEEE 123-bus feeder system, measured residential loads, and EWH power simulated based on realistic hot water draws from CBECC-Res software. The demand response control, which complies to CTA-2045 standards was implemented to the EWHs considering the energy take values. Results demonstrate that the EWHs can be controlled to postpone the peak power at the distribution system level and provide a large amount of energy storage, while maintaining system robustness. The impact on occupant comfort was also analyzed.
Techno-Economic Analysis of Electrocoagulation on Water Reclamation and Bacterial/Viral Indicator Reductions of a High-Strength Organic Wastewater—Anaerobic Digestion Effluent (2020)

This study investigated the use of iron and aluminum and their combinations as electrodes to determine the technically sound and economically feasible electrochemical approach for the treatment of anaerobic digestion effluent. The results indicated that the use of iron as anode and cathode is the most suitable solution among different electrode combinations. The reduction of turbidity, total chemical oxygen demand, total phosphorus, total coliforms, Escherichia coli, Enterococci, and phages in the reclaimed water were 99%, 91%, 100%, 1.5 log, 1.7 log, 1.0 log, and 2.0 log, respectively. The economic assessment further concluded that the average treatment cost is $3 per 1000 L for a small-scale operation handling 3000 L wastewater/day. This study demonstrated that the electrocoagulation (EC) is a promising technique for the recovery and reclamation of water from anaerobic digestion effluent. Even though its energy consumption is higher and the nitrogen removal is insufficient compared to some conventional wastewater treatment technologies, there are several advantages of the EC treatment, such as short retention time, small footprint, no mixing, and gradual addition of coagulants. These features make EC technology applicable to be used alone or combined with other technologies for a wide range of wastewater treatment applications.
Safe Supervisory Control of Soft Robot Actuators (2022)

Although soft robots show safer interactions with their environment than traditional robots, soft mechanisms and actuators still have significant potential for damage or degradation particularly during unmodeled contact. This article introduces a feedback strategy for safe soft actuator operation during control of a soft robot. To do so, a supervisory controller monitors actuator state and dynamically saturates control inputs to avoid conditions that could lead to physical damage. We prove that, under certain conditions, the supervisory controller is stable and verifiably safe. We then demonstrate completely onboard operation of the supervisory controller using a soft thermally-actuated robot limb with embedded shape memory alloy (SMA) actuators and sensing. Tests performed with the supervisor verify its theoretical properties and show stabilization of the robot limb's pose in free space. Finally, experiments show that our approach prevents overheating during contact (including environmental constraints and human contact) or when infeasible motions are commanded. This supervisory controller, and its ability to be executed with completely onboard sensing, has the potential to make soft robot actuators reliable enough for practical use.
Linear-regression models (2000)

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In Situ Mass Spectrometry in Marine Science; Distribution and Quantification of Submarine Methane Sources (2016)

We present the in situ use of an underwater mass spectrometer (UWMS) for the detection and quantification of active submarine methane seeps. The key benefit of using this novel technique is the rapid instrumental response, which allows an up to 750 times higher sampling frequency of dissolved gas concentrations compared to other methods. Among other major and trace gases, the increased data density and accuracy allows for the improved determination of methane point-sources. &#13;\nMethane is the most abundant organic compound in the atmosphere and its influence on global climate is the subject of current scientific discussion. One source of atmospheric methane with variable strength is the ocean’s seafloor e.g. through the destabilization of gas hydrates. These submarine methane sources are characterized by rising gas bubbles and/or the diffusive flux of gas into the water column. While ex situ sampling methods are limited by the time and costs, the primary limitation is the difficulty in capturing concentrations that are highly dynamic in time and space. Using an optimized UWMS (significantly improved in detection limit by a cryo-trap system) in the North Sea (Atlantic Ocean), we have obtained high-resolution 3D distribution patterns of dissolved methane in the water column. &#13;\nIn addition to presenting novel methodologies using in situ mass spectrometry to detect, map and calculate the methane inventory above submarine sources, we will present a new configuration of instruments to determine the diffusive transportation rates at the sediment-water-transition-zone.&#13;\n
Waveshifters and scintillators for the detection of ionizing radiation (2003)

New waveshifter and scintillator materials are under development for use in detecting charged particles in tracking applications and for detecting showering particles in calorimetric applications. Goals have been to identify and produce fast and efficient dye materials that fluoresce in the middle of the visible spectrum where polystyrene and polyvinyltoluene have good optical transparency, to replace existing materials currently in use in the field of particle physics. As a result of this study, several fluorescent dyes have been identified with fast and efficient emission, that fluorescence in the green (/spl lambda/ /spl sim/ 490-520 nm), and from these a number waveshifter and scintillator materials have been fabricated.
3,4,6-Tri-O-acetyl-2-deoxy-2-[18F]fluoroglucopyranosyl Phenylthiosulfonate:  A Thiol-Reactive Agent for the Chemoselective18F-Glycosylation of Peptides (2006)

3,4,5-Tri-O-acetyl-2-[18F]fluoro-2-deoxy-d-glucopyranosyl 1-phenylthiosulfonate (Ac3-[18F]FGlc-PTS) was developed as a thiol-reactive labeling reagent for the site-specific 18F-glycosylation of peptides. Taking advantage of highly accessible 1,3,4,6-tetra-O-acetyl-2-deoxy-2-[18F]fluoroglucopyranose, a three-step radiochemical pathway was investigated and optimized, providing Ac3-[18F]FGlc-PTS in a radiochemical yield of about 33% in 90 min (decay-corrected and based on starting [18F]fluoride). Ac3-[18F]FGlc-PTS was reacted with the model pentapeptide CAKAY, confirming chemoselectivity and excellent conjugation yields of >90% under mild reaction conditions. The optimized method was adopted to the 18F-glycosylation of the alphavbeta3-affine peptide c(RGDfC), achieving high conjugation yields (95%, decay-corrected). The alphavbeta3 binding affinity of the glycosylated c(RGDfC) remained uninfluenced as determined by competition binding studies versus 125I-echistatin using both isolated alphavbeta3 and human umbilical vein endothelial cells (Ki = 68 +/- 10 nM (alphavbeta3) versus Ki = 77 +/- 4 nM (HUVEC)). The whole radiosynthetic procedure, including the preparation of the 18F-glycosylating reagent Ac3-[18F]FGlc-PTS, peptide ligation, and final HPLC purification, provided a decay-uncorrected radiochemical yield of 13% after a total synthesis time of 130 min. Ac3-[18F]FGlc-PTS represents a novel 18F-labeling reagent for the mild chemoselective 18F-glycosylation of peptides indicating its potential for the design and development of 18F-labeled bioactive S-glycopeptides suitable to study their pharmacokinetics in vivo by positron emission tomography (PET).
An integrative quantitative model of factors influencing the course of anorexia nervosa over time (2008)

Elevated anxiety and eating-related obsessionality may increase the risk for the development of AN and for nonremission.