gebhart/patrepeval huggingface dataset:
Assessment of lifetime of hot‐water polyethylene pipes based on oxidation induction time data (1998)

Abstract A method is presented for assessment of lifetime of polyethylene pipes undergoing thermal oxidation (Stage III failure) based on oxidation induction time ( OIT ) data obtained by DSC. The method requires pressure testing for limited time periods, sampling from unexposed and exposed pipes, the establishment of a linear relationship between the OIT and the antioxidant concentration, and the taking of OIT profiles through the pipe wall. The method is not applicable to pipes with improper dispersion of the antioxidant. A mathematical procedure based on a model for the migration and chemical consumption of the antioxidant system is used to extrapolate short‐term OIT profiles to obtain the OIT profiles after extended exposure. The lifetime prediction is also based on the empirical establishment of a criterion, a critical OIT value, for the onset of thermal oxidation of the polymer (Regime C). The total lifetime is then obtained under the assumption that the time period of Regime C constitutes 10% of the total lifetime. The pressure testing time required to obtain adequate data for modeling is only a fraction (20% to 70%) of the failure times of the pipes studied. The average difference between the actual and predicted times was 15% for the MDPE pipes studied.
Managing Risks of IT Outsourcing (2011)

Outsourcing is one of the most talked about and widely debated topics. Over the past few years, firms have been outsourcing their IT operations at increasing rates. The fact that firms are turning to outside vendors in increasing numbers in order to meet their needs does not mean that outsourcing is without problems. Firms often enter outsourcing deals without considering risks or assuming that all risks lay with the external service provider. In this chapter, we provide an overview of IT outsourcing, its risks, and a model for managing those risks. We identify different firm-vendor configurations for sustaining long-term relationships aimed at diversifying risk over time and discuss the need for psychological contracts to manage such outsourcing relationships.
A Nonlinear Reduced-Order Model for Electrostatic MEMS (2003)

We present an analytical approach and a reduced-order model (macromodel) to investigate the behavior of electrically actuated microbeam-based MEMS. The macromodel provides an effective and accurate design tool for this class of MEMS devices. The macromodel is obtained by discretizing the distributed-parameter system using a Galerkin procedure into a finite-degree-of-freedom system consisting of ordinary-differential equations in time. The macromodel accounts for moderately large deflections, dynamic loads, and the coupling between the mechanical and electrical forces. It accounts for linear and nonlinear elastic restoring forces and the nonlinear electric forces generated by the capacitors. A new technique is developed to represent the electric force in the equations of motion. The new approach allows the use of few linear-undamped mode shapes of a microbeam in its straight position as basis functions in a Galerkin procedure. The macromodel is validated by comparing its results with experimental results and finiteelement solutions available in the literature. Our approach shows attractive features compared to finite-element softwares used in the literature. It is robust over the whole device operation range up to the instability limit of the device (i.e., pull-in). Moreover, it has low computational cost and allows for an easier understanding of the influence of the various design parameters. As a result, it can be of significant benefit to the development of MEMS design software.
Stereocontrolled Access to Enantiopure 7-Substituted cis- and trans-Octahydroindoles (2016)

Cyclocondensation of (R)-phenylglycinol with stereoisomeric mixtures (racemates, cis/trans) of 3-substituted 2-oxocyclohexaneacetates stereoselectively afforded tricyclic oxazoloindolone lactams, from which straightforward procedures for the stereocontrolled formation of enantiopure 7-substituted octahydroindoles with a variety of stereochemical patterns have been developed. The methodology has been successfully applied to the synthesis of (+)-α-lycorane.
Network under Control: Multi-Vehicle E2E Measurements for AI-based QoS Prediction (2021)

In the future, mobility use cases will depend on precise predictions, with Quality of Service (QoS) prediction being a prominent example. This paper presents realistic measurements from today’s vehicles to support robust QoS prediction in the future. Based on a dedicated and controlled measurement campaign, we highlight aspects of the wireless environment and the device characteristics, like the sampling rates, that influence the collected datasets. If not properly handled, such characteristics might hinder the performance of Artificial Intelligence-based algorithms for QoS prediction. Therefore, we also provide insights on dataset characteristics that should be further used to enable easier adoption of AI-based algorithms. New AI-based algorithms should be able to operate in very diverse radio environments with data captured from different devices. We provide several examples that highlight the importance of thoroughly understanding the datasets and their dynamics.
Database Workload Management (Dagstuhl Seminar 12282) (2012)

This report documents the program and the outcomes of Dagstuhl Seminar 12282 "Database Workload Management". Dagstuhl Seminar 12282 was designed to provide a venue where researchers can engage in dialogue with industrial participants for an in-depth exploration of challenging industrial workloads, where industrial participants can challenge researchers to apply the lessons-learned from their large-scale experiments to multiple real systems, and that would facilitate the release of real workloads that can be used to drive future research, and concrete measures to evaluate and compare workload management techniques in the context of these workloads.
Influence of digital rectal massage on urinary prostate-specific antigen: Interest for the detection of local recurrence after radical prostatectomy (1998)

uPSA before and after massage of the prostatic fossa may constitute a new and efficient tool for the detection of local recurrence, if these preliminary results are confirmed on a larger scale.
The Impact of a Stepwise Approach to Primary Tumor Detection in Squamous Cell Carcinoma of the Neck With Unknown Primary (2018)

4 Laryngoscope, 129:1610-1616, 2019.
Intercostal Cryo Nerve Block in Minimally Invasive Cardiac Surgery: The Prospective Randomized FROST Trial (2021)

Clinicaltrials.gov identifier: NCT02922153.
Optical Transmission: Enhanced Optical Transmission through MacEtch‐Fabricated Buried Metal Gratings (Adv. Mater. 7/2016) (2016)

On page 1441, D. Wasserman and co-workers demonstrate a nanostructured thin film formed by engraving a thin, patterned metal layer into a semiconductor substrate via the MacEtch technique. The patterned film allows for enhanced electrical contact and simultaneously transmits more light than a smooth air-semiconductor interface. The demonstrated approach has the potential for integration with a wide range of optoelectronic devices.
Résolution de Métonymie des Entités Nommées : proposition d'une méthode hybride (2009)

International audience
Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19 (2023)

Age was the strongest determinant of risk of death, with a ∼30-fold difference between the oldest and youngest groups; each of the co-morbidities included was associated with up to an almost 2-fold increase in risk. Smoking and obesity were also associated with a higher risk of death. The size of our international database and the standardized data collection method make this study a comprehensive international description of COVID-19 clinical features. Our findings may inform strategies that involve prioritization of patients hospitalized with COVID-19 who have a higher risk of death.
Kindlin-2 directly binds actin and regulates integrin outside-in signaling (2016)

Reduced levels of kindlin-2 (K2) in endothelial cells derived from K2(+/-)mice or C2C12 myoblastoid cells treated with K2 siRNA showed disorganization of their actin cytoskeleton and decreased spreading. These marked changes led us to examine direct binding between K2 and actin. Purified K2 interacts with F-actin in cosedimentation and surface plasmon resonance analyses and induces actin aggregation. We further find that the F0 domain of K2 binds actin. A mutation, LK(47)/AA, within a predicted actin binding site (ABS) of F0 diminishes its interaction with actin by approximately fivefold. Wild-type K2 and K2 bearing the LK(47)/AA mutation were equivalent in their ability to coactivate integrin αIIbβ3 in a CHO cell system when coexpressed with talin. However, K2-LK(47)/AA exhibited a diminished ability to support cell spreading and actin organization compared with wild-type K2. The presence of an ABS in F0 of K2 that influences outside-in signaling across integrins establishes a new foundation for considering how kindlins might regulate cellular responses.
Dibenzylzirconium Complexes of Chelating Aminodiolates. Synthesis, Structural Studies, Thermal Stability, and Insertion Chemistry (2000)

Aminodiolate ligands, RN(CH2CH2C(O)R‘2)2 (1a−e), allow the isolation of soluble, monomeric zirconium dialkyl complexes, [RN(CH2CH2C(O)R‘2)2]ZrR‘ ‘2 (2a−e, 5, 6). The fluxional behavior and thermal stability of these complexes are strongly dependent on the nature of the substituents at the nitrogen center, with smaller substituents (R = Me; 2a,b, 5, 6) increasing the rigidity and thermal stability of the complexes. Complexes bearing tert-butyl groups (2c,d) readily undergo thermal decomposition by elimination of isobutene. Thermal ortho metalation of the chiral complex Zr[((S)-PhC(H)Me)N(CH2CH2C(O)Me2][CH2Ph]2 (2e) affords the chiral metallacycle Zr[N{CH2CH2C(O)Me2}2{((S)-2-C6H4C(H)Me}][CH2Ph] (7), which has been structurally characterized. Reaction of 7 with 1 equiv of aryl aldehyde (ArC(O)H; Ar = Ph, β-naphthyl) results in regiospecific insertion of the aldehyde into the phenyl−zirconium bond. The resulting aminotriolate complex Zr[N{CH2CH2C(O)Me2}2{((S)-2-((R)-(β-naphthyl)CH(O))-C6H4C(H)Me}][CH2Ph] (8b) is formed in 91% de and has been characterized by X-ray crystallography. Further insertion of ArC(O)H into the remaining Zr−benzyl bond of 8b proceeds with poorer stereochemical control. Complex 7 also catalyzes the slow cyclotrimerization of phenylacetylene to 1,2,4- and 1,3,5-triphenylbenzene (2.5 turnovers/day). Complexes 2b,d and 7 function as precatalysts for ethylene polymerization when treated with MAO activator, although the activity is very low.
Targeting Proinflammatory Molecules Using Multifunctional MnO Nanoparticles to Inhibit Breast Cancer Recurrence and Metastasis (2022)

Photothermal therapy (PTT) is an effective treatment modality that is highly selective for tumor suppression and is a hopeful alternative to traditional cancer therapy. However, PTT-induced inflammatory responses may result in undesirable side effects including increased risks of tumor recurrence and metastasis. Here we developed multifunctional MnO nanoparticles as scavengers of proinflammatory molecules to alleviate the PTT-induced inflammatory response. The MnO nanoparticles improve the PTT therapy by (1) binding and scavenging proinflammatory molecules to inhibit the proinflammatory molecule-induced Toll-like receptors (TLR) activation and nuclear factor kappa B (NF-κB) signaling; (2) inhibiting activated macrophage-induced macrophage recruitment; and (3) inhibiting tumor cell migration and invasion. In vivo experimental results showed that further treatment with MnO nanoparticles after laser therapy not only inhibited the PTT-induced inflammatory response and primary tumor recurrence but also significantly reduced tumor metastasis due to the scavenging activity. These findings suggest that MnO nanoparticles hold the potential for mitigating the therapy-induced severe inflammatory response and inhibiting tumor recurrence and metastasis.
CLEC4F Is an Inducible C-Type Lectin in F4/80-Positive Cells and Is Involved in Alpha-Galactosylceramide Presentation in Liver (2013)

CLEC4F, a member of C-type lectin, was first purified from rat liver extract with high binding affinity to fucose, galactose (Gal), N-acetylgalactosamine (GalNAc), and un-sialylated glucosphingolipids with GalNAc or Gal terminus. However, the biological functions of CLEC4F have not been elucidated. To address this question, we examined the expression and distribution of murine CLEC4F, determined its binding specificity by glycan array, and investigated its function using CLEC4F knockout (Clec4f-/-) mice. We found that CLEC4F is a heavily glycosylated membrane protein co-expressed with F4/80 on Kupffer cells. In contrast to F4/80, CLEC4F is detectable in fetal livers at embryonic day 11.5 (E11.5) but not in yolk sac, suggesting the expression of CLEC4F is induced as cells migrate from yolk cells to the liver. Even though CLEC4F is not detectable in tissues outside liver, both residential Kupffer cells and infiltrating mononuclear cells surrounding liver abscesses are CLEC4F-positive upon Listeria monocytogenes (L. monocytogenes) infection. While CLEC4F has strong binding to Gal and GalNAc, terminal fucosylation inhibits CLEC4F recognition to several glycans such as Fucosyl GM1, Globo H, Bb3∼4 and other fucosyl-glycans. Moreover, CLEC4F interacts with alpha-galactosylceramide (α-GalCer) in a calcium-dependent manner and participates in the presentation of α-GalCer to natural killer T (NKT) cells. This suggests that CLEC4F is a C-type lectin with diverse binding specificity expressed on residential Kupffer cells and infiltrating monocytes in the liver, and may play an important role to modulate glycolipids presentation on Kupffer cells.
Evaluation of a New Vocus Reagent-Ion Source and Focusing Ion-Molecule Reactor for use in Proton-Transfer-Reaction Mass Spectrometry (2018)

We evaluate the performance of a new chemical ionization source called Vocus, consisting of a discharge reagent-ion source and focusing ion-molecule reactor (FIMR) for use in protontransfer-reaction time-of-flight mass spectrometry (PTR-TOF) measurements of volatile organic compounds (VOCs) in air. The reagent ion source uses a low-pressure discharge. The FIMR consists of a glass tube with a resistive coating, mounted inside a radio-frequency (RF) quadrupole. The axial electric field is used to enhance ion collision energies and limit cluster ion formation. The RF field focuses ions to the central axis of the reactor and improves the detection efficiency of product ions. Ion trajectory calculations demonstrate the mass-dependent focusing of ions and enhancement of the ion collision energy by the RF field, in particular for the lighter ions. Product ion signals are increased by a factor of 10 when the RF field is applied (5,000-18,000 cps ppbv-1), improving measurement precision and detection limits while operating at very similar reaction conditions as traditional PTR instruments. Due to the high water mixing ratio in the FIMR, we observe no dependence of the sensitivity on ambient sample humidity. In this work, the Vocus is interfaced to a TOF mass analyzer with a mass resolving power up to 14,000, which allows clear separation of isobaric ions, observed at nearly every nominal mass when measuring ambient air. Measurement response times are determined for a range of ketones with saturation vapor concentrations down to 5×104 μg m-3 and compare favorably with previously published results for a PTR-MS instrument.
Chameleon: Application-Level Power Management (2008)

In this paper, we present Chameleon an application-level power management approach for reducing energy consumption in mobile processors. By using application domain knowledge, as opposed to OS-level or hardware-level inferred knowledge, Chameleon can substantially reduce CPU energy consumption. By exporting the energy management to user-space, designers can design more flexible and easily portable algorithms and systems, and use multiple energy management policies simultaneously. Specifically, we propose a minimal operating system interface that applications use to obtain global knowledge from the kernel in order to make local decisions. We consider three classes of applications soft real-time, interactive and batch and design user level power management strategies for representative applications such as a movie player, a word processor, a web browser, and a batch compiler. Our experiments show that, compared to the traditional system-wide CPU voltage scaling approaches, Chameleon can achieve up to 32-50% energy savings while delivering comparable or better performance to applications. Similarly, Chameleon extracts 9-41% more energy when compared to Grace OS, which uses some application knowledge but operates within the kernel. Further, Chameleon imposes minimal overhead and is effective at scheduling concurrent applications with diverse energy needs.
Design and Implementation of Embedded Miniature Bandpass Filters for RF-System-in-Organic-Package Applications (2007)

A simple bandpass filter architecture composed of three spiral inductors and two parallel-plate capacitors is presented to be suitable for being embedded in a low-cost organic laminate substrate for RF system-in-package applications. Although only five components are used, the presented organic bandpass filter designs can feature themselves with a third-order Chebyshev response plus multiple transmission zeros, resulting in a low and flat insertion loss in the passband as well as a high attenuation rate in the roll-off region. Due to the use of so few components, the organic bandpass filters implemented in the proposed architecture can be size-competitive with the low-temperature cofired ceramic (LTCC) bandpass filters.
Nanoporous alumina membranes based microdevices for ultrasensitive protein detection (2008)

Electrical and chemical properties of nanostructured alumina membranes have been used to improve sensitivity and performance of Si-based microdevices for protein sensing. Trapping of proteins within the nanoscale well-like structures is an experimental demonstration of “molecular crowding” phenomenon retaining the functionality of proteins due to confinement in small spaces i.e. nanowells. Protein conjugation in nanowells causes charge perturbation in the electrical double layer at the interface between biomolecule and gold electrode, measured as capacitance change. We have demonstrated the detection of cardiovascular biomarkers, C-reactive protein (CRP) and Myeloperoxidase (MPO), from purified samples and human serum. The device performance metrics - sensitivity, selectivity, speed and dynamic range of detection - have been measured to quantify the efficacy of these nanomonitors and compared to standard immunoassays.
AN ENHANCED MICROSOFT HOLOLENS® AUGMENTED REALITY PLATFORM FOR TRAINING IN ACETABULAR CUP IMPLANT ORIENTATION: A RANDOMIZED CONTROLLED TRIAL (2018)

Background Complications such as dislocations, impingement and early wear following total hip arthroplasty (THA) increase with acetabular cup implant malorientation. These errors are more common with low-volume centres or in novice hands. Currently, this skill is most commonly taught during real surgery with an expert trainer, but simulated training may offer a safer and more accessible solution. This study investigated if a novel MicronTracker® enhanced Microsoft HoloLens® augmented reality (EAR) headset was as effective as one-on-one expert surgeon (ES) training for teaching novice surgeons hip cup orientation skill. Methods Twenty-four medical students were randomly assigned to EAR or ES training groups. Participants used a modified sawbone/foam pelvis model for hip cup orientation simulation. A validated EAR headset measured the orientation of acetabular cup implants and displayed this in the participant”s field of view. The system calculated the difference between planned and achieved orientation as ...
Optimization of NAMPT (Nicotinamide Phosphoribosyltransferase) Activators: Discovery of N,N-Diethyl-1,2-benzoxazole-3-carboxamide Derivatives as Potent NAMPT Activators with Mitigated Mutagenic Risks (2021)

DS68702229, a potent NAMPT activator developed from HTS followed by a hit-to-lead campaign, is a promising candidate compound that significantly reduced body weight when orally administered to mice with high fat diet-induced obesity. However, in vitro toxicology profiling of DS68702229 revealed bacterial mutagenicity using Salmonella typhimurium TA98 and TA100 strains upon S9 activation. Hypothesizing that DNA intercalation is the likely cause, we employed several approaches to disrupt the putative DNA intercalation, including modulation of the molecular shape. Our efforts culminated in the discovery of compounds 20k and 20l, which increased intracellular NAD + levels in a cell-based assay without inducing mutagenicity, along with acceptable plasma exposure in mice after oral administration.
Driven Dynamics and Rotary Echo of a Qubit Tunably Coupled to a Harmonic Oscillator (2012)

We have investigated the driven dynamics of a superconducting flux qubit that is tunably coupled to a microwave resonator. We find that the qubit experiences an oscillating field mediated by off-resonant driving of the resonator, leading to strong modifications of the qubit Rabi frequency. This opens an additional noise channel, and we find that low-frequency noise in the coupling parameter causes a reduction of the coherence time during driven evolution. The noise can be mitigated with the rotary-echo pulse sequence, which, for driven systems, is analogous to the Hahn-echo sequence.
Synthesis and characterization of polyetherimides containing multiple ether linkages and pendent pentadecyl chains (2015)

Abstract 4‐(4‐(4‐(4‐Aminophenoxy)‐2‐pentadecylphenoxy)phenoxy)aniline ( APPPA ) was synthesized starting from cashew nut shell liquid‐derived bisphenol, i.e. 4‐(4‐hydroxyphenoxy)‐3‐pentadecylphenol, by nucleophilic substitution reaction with 4‐chloronitrobenzene followed by reduction of the formed 4‐(4‐nitrophenoxy)‐1‐(4‐(4‐nitrophenoxy)phenoxy)‐2‐pentadecylbenzene. Three new polyetherimides containing multiple ether linkages and pendent pentadecyl chains were synthesized by one‐step high‐temperature solution polycondensation of APPPA in m ‐cresol with three aromatic dianhydrides, i.e. 3,3′,4,4′‐oxydiphthalic anhydride, 4,4′‐(hexafluoroisopropylidene)diphthalic anhydride and 3,3′,4,4′‐biphenyltetracarboxylic dianhydride. Inherent viscosities and number‐average molecular weights of the polyetherimides were in the ranges 0.66–0.70 dL g −1 and 17 100–29 700 g mol −1 (gel permeation chromatography, polystyrene standards), respectively, indicating the formation of reasonably high molecular weight polymers. The polyetherimides were soluble in organic solvents such as chloroform, dichloromethane, tetrahydrofuran, pyridine, m ‐cresol, N , N ‐dimethylformamide, N , N ‐dimethylacetamide, N ‐methylpyrrolidone and dimethylsulfoxide, and could be cast into transparent, flexible and tough films from their solutions in chloroform. The polyetherimides exhibited glass transition temperatures ( T g ) in the range 113–131 °C. The lowering of T g could be attributed to the combined influence of flexibilizing ether linkages and pentadecyl chains which act as ‘packing‐disruptive’ groups. The temperature at 10% weight loss ( T 10 ), determined from thermogravimetric analysis in nitrogen atmosphere, was in the range 460–470 °C demonstrating good thermal stability. The virtues of solubility and large gap between T g and T 10 mean that the polyetherimides containing pendent pentadecyl chains have possibilities for both solution as well as melt processability. © 2015 Society of Chemical Industry