gebhart/patrepeval huggingface dataset:
Ambient light emission from hydrothermal vents on the Mid‐Atlantic Ridge (2002)

A spectral imaging camera was used to observe light emission from high‐temperature, deep‐sea vents at three hydrothermal sites on the Mid‐Atlantic Ridge (MAR): Logatchev, Snake Pit, and Lucky Strike. Ambient light measured at these sites is similar to that observed at sites along the East Pacific Rise and the Juan de Fuca Ridge, with components from both thermal and non‐thermal sources. The shrimp species Rimicaris exoculata , which is found on the MAR but not in the Eastern Pacific, possesses a unique photoreceptor capable of detecting low light levels. It is not yet known if R. exoculata “sees” vent light. However, since the characteristics of vent light appear to be unrelated to geographical location, the exclusion of R. exoculata from the Eastern Pacific is probably unrelated to differences in ambient light conditions.
Self-referenced CEO Frequency Detection of a Semiconductor Disk Laser using a Silicon Nitride Waveguide (2017)

We present the self-referenced detection of the carrier-envelope offset (CEO) frequency of a gigahertz SESAM-modelocked VECSEL with a coherent octave-spanning supercontinuum generated in a silicon nitride waveguide without the need of external pulse amplification.
Ductile to Brittle Transition Depth During Single‐Grit Scratching on Alumina Ceramics (2007)

Variable‐depth single‐grit scratch experiments have been conducted on three different grain size alumina ceramics. The extent of induced damage as a function of depth of groove was measured. At low depth, the scratch groove appeared smooth with minimal brittle damage, indicating a ductile mode of deformation. With increased depth, brittle cracking extended beyond the scratch groove. The transition depth from the predominantly ductile mode of deformation to the predominantly brittle mode was measured and compared with an analytical model that estimates the plastic zone size surrounding a scratch in brittle materials. It was found that the ductile to brittle transition depth increases with decreasing grain size.
Helicobacter pylori‐induced apoptosis in T cells is mediated by the mitochondrial pathway independent of death receptors (2007)

H. pylori-induced apoptosis of T cells is mediated by the mitochondrial pathway and could create a local environment that facilitates life-long infection by immune evasion.
Real-time, functional intra-operative localization of rat cavernous nerve network using near-infrared cyanine voltage-sensitive dye imaging (2019)

Abstract Despite current progress achieved in the surgical technique of radical prostatectomy, post-operative complications such as erectile dysfunction and urinary incontinence persist at high incidence rates. In this paper, we present a methodology for functional intra-operative localization of the cavernous nerve (CN) network for nerve-sparing radical prostatectomy using near-infrared cyanine voltage-sensitive dye (VSD) imaging, which visualizes membrane potential variations in the CN and its branches (CNB) in real time. As a proof-of-concept experiment, we demonstrate a functioning complex nerve network in response to electrical stimulation of the CN, which was clearly differentiated from surrounding tissues in an in vivo rat prostate model. Stimulation of an erection was confirmed by correlative intracavernosal pressure (ICP) monitoring. Within 10 minutes, we performed trans-fascial staining of the CN by direct VSD administration. Our findings suggest the applicability of VSD imaging for real-time, functional imaging guidance during nerve-sparing radical prostatectomy.
Experience of a 2-year spinal muscular atrophy NBS pilot study in Italy: towards specific guidelines and standard operating procedures for the molecular diagnosis (2022)

The molecular diagnosis of SMA needs to adapt to the new era of the disease with specific guidelines and standard operating procedures. In detail, SMA diagnosis should be felt as a true medical urgency due to therapeutic implications; <i>SMN2</i> copy assessment needs to be standardised; commercially available tests need to be improved for higher <i>SMN2</i> copies determination; and the <i>SMN2</i> splicing-modifier variants should be routinely tested in SMA-NBS.
Post-placement interconnect entropy (2006)

We introduce the concept of post-placement interconnect entropy: the minimal number of bits required to describe a well-placed netlist, which has connection lengths distributed according to Rent's rule. The entropy is a function of the number N of cells in the netlist and the Rent exponent p. We derive an expression for the entropy per cell and show that it converges as N approaches infinity. The entropy provides an achievable lower bound on the number of configuration bits in a programmable logic device. Specific numerical values are computed for practical situations. For example, any scalable FPGA composed of 4-input lookup table cells would require 31 configuration bits per cell. We compare this to the actual number of configuration bits in a standard FPGA architecture. We generalize the bound to dimensions higher than two, and show that for any p there is an optimal dimension that minimizes the bound.
Synthesis and reactivity of a series of analogous rhenium tris(imido), bis(imido) alkyne, and imido bis(alkyne) complexes (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and reactivity of a series of analogous rhenium tris(imido), bis(imido) alkyne, and imido bis(alkyne) complexesDarryl S. Williams and Richard R. SchrockCite this: Organometallics 1993, 12, 4, 1148–1160Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April 1993https://pubs.acs.org/doi/10.1021/om00028a032https://doi.org/10.1021/om00028a032research-articleACS PublicationsRequest reuse permissionsArticle Views432Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Exquisite Selectivity for Human Toll-Like Receptor 8 in Substituted Furo[2,3-c]quinolines (2013)

Toll-like receptor (TLR)-8 agonists activate adaptive immune responses by inducing robust production of T helper 1-polarizing cytokines, suggesting that TLR8-active compounds may be promising candidate adjuvants. We synthesized and evaluated hitherto unexplored furo[2,3-c]quinolines and regioisomeric furo[3,2-c]quinolines derived via a tandem, one-pot Sonogashira coupling and intramolecular 5-endo-dig cyclization strategy in a panel of primary screens. We observed a pure TLR8-agonistic activity profile in select furo[2,3-c]quinolines, with maximal potency conferred by a C2-butyl group (EC50 = 1.6 μM); shorter, longer, or substituted homologues as well as compounds bearing C1 substitutions were inactive, which was rationalized by docking studies using the recently described crystal structure of human TLR8. The best-in-class compound displayed prominent proinflammatory cytokine induction (including interleukin-12 and interleukin-18), but was bereft of interferon-α inducing properties, confirming its high selectivity for human TLR8.
Intradomain QoS routing in IP networks: a feasibility and cost/benefit analysis (1999)

Constraint-based routing gradually becomes an essential enabling mechanism for a variety of emerging network services such as virtual private networking and QoS support. A number of previous works have recognized its significance and investigated many aspects of the operation of constraint-based routing and in particular its variant concerned with determining paths for requests with specific QoS requirements, known as QoS routing. In this work we build on previous results on the cost of QoS routing and investigate the performance/cost trade-offs involved in the operation of a representative QoS routing architecture, elaborate on the constituents of this cost, and identify the main methods for containing the cost that QoS routing incurs on routers. Our results show that the cost of QoS routing is not excessive and that there indeed exist operational configurations, which can achieve reasonable performance gains with only a minimal increase in processing cost when compared to conventional best-effort routing.
Cloning of the gene, speB, for streptococcal pyrogenic exotoxin type B in Escherichia coli (1988)

The structural gene encoding streptococcal pyrogenic exotoxin type B, designated speB, was cloned in Escherichia coli and localized onto a 4.5-kilobase BamHI-BglII DNA fragment. Streptococcal pyrogenic exotoxin type B, partially purified from E. coli clones, was immunologically related to streptococcus-derived toxin. Also, toxin derived from either E. coli or Streptococcus pyogenes had similar lymphocyte mitogenic activity and molecular weight (29,300) and displayed comparable microheterogeneity when evaluated by isoelectric focusing.
Spinal Cord Stimulation for Chronic, Intractable Pain (1994)

Departments of Neurosurgery and Biostatistics, The Johns Hopkins University School of Medicine, Baltimore, Maryland
Enantioselective Addition of Chiral Organotitanium Derivatives to Aldehydes (1981)

Abstract Alkoxy‐ and aryloxy‐organotitanium compounds 2–4 derived from ( S )‐2‐methyl‐1‐butanol, ( R )‐2‐butanol, (‐)‐menthol, quinine, cinchonine, and ( S )‐1.1′‐binaphthol are added to aromatic aldehydes to give optically active alcohols 5–10 in enantioselectivities of up to 88% e. e., with nucleophilic transfer of methyl, phenyl, and 1‐naphthyl groups. The Tables 1–3 list the effects of varying the reagents, the substrates, and the reaction conditions of the new asymmetric synthesis.
Translation of Illustration Artist Style Using Sailormoonredraw Data (2022)

The decision to draw requires answers to two questions: what to draw and how to draw. The latter refers to artist style and is an important factor in creating any illustration. In this paper, we propose a novel task, artist style translation, which translates one artist’s illustration into that of another artist style using deep learning. To solve this task in a supervised manner, we created a novel illustration dataset, SailormoonDataset, which consists of more than 2,000 artist’s stylistic illustrations of the same content. In addition, we propose a method based on the Swapping Autoencoder by introducing a new loss function for supervised learning and using multiple images to represent an artist style. We translate the face illustration of Sailor Moon into styles of different artists. By comparing the current results to those of the Swapping Autoencoder, we find that the proposed method successfully achieves the artist style translation.
Expect the unexpected: more possibilities for organic electronics (2020)

Abstract There are a plethora of devices and phenomena that have been explored beyond the more conventional topics covered in the previous eight chapters. In this chapter, several of these interesting and promising topics in organic electronics are introduced. These include electrochemical light emitting devices, strong coupling between excitons and photons in optical microcavities forming so-called exciton polaritons and their associated devices, organic memory devices, and organics in limited dimensional systems. This latter topic includes discussions of energy transfer between organics and two-dimensional electronic materials, and single molecule, one-dimensional devices and phenomena. In each case, the discussions begin with an introduction to the subject, followed by laying the theoretical foundations of device operation, and finally by presenting several exemplary results that illuminate critical concepts. The purpose of this choice of topics is to show the endless horizons that are open to further investigation in the field of organic electronics.
Charting the road forward in psychiatric neurosurgery: proceedings of the 2016 American Society for Stereotactic and Functional Neurosurgery workshop on neuromodulation for psychiatric disorders (2018)

Interest and motivation remain strong for deep brain stimulation for psychiatric disease. Progress will require coordinated efforts by all stakeholders.
Persistence of Human Herpesvirus 6 According to Site and Variant: Possible Greater Neurotropism of Variant A (1998)

Little is known of the persistence and pathogenicity of human herpesvirus 6 (HHV-6) after primary infection, including the role of strain variant. Over 2 to 5 years, 2,716 children and 149 families were studied. Peripheral blood mononuclear cell (PBMC), saliva, and cerebrospinal fluid (CSF) specimens were examined for HHV-6 DNA and variant. Ninety-nine percent of isolates causing primary infection were HHV-6 variant B (HHV-6B), which predominated in 95%-98% of the variants persisting in PBMC and saliva specimens from children and adults. Of 668 CSF samples, 13% contained HHV-6 DNA; of 77 children examined after primary infection, 61% had HHV-6 DNA detected only in their CSF and 39% had HHV-6 DNA in both CSF and PBMCs. HHV-6 variant A (HHV-6A) was detected significantly (P = .0001) more frequently in CSF than in PBMCs or saliva. In children for whom HHV-6 was identified in both CSF and PBMCs, PBMCs contained only HHV-6B, while CSF contained HHV-6A or HHV-6B, not both. Thus, in patients with dual infection, only HHV-6A persisted in CSF, which suggests that HHV-6A has greater neurotropism. Findings for adults indicate that dual infection occurs; variant persistence is similar to that for children. The frequency of HHV-6A infection increased little with age, thereby indicating that HHV-6A infection remains uncommon into adulthood. This study suggests that HHV-6 variants have different immunobiologic courses and neurotropism.
Signal and noise analysis of small antennas terminated with high-impedance amplifiers (2007)

We consider the noise performance of an active antenna with high impedance amplifier as a receiver front end for an electrically small antenna. In comparison to standard impedance matching techniques, the resulting output signal to noise ratio may be suboptimal, but the bandwidth is much broader than can be achieved when a small antenna with high Q-factor is matched to a standard microwave amplifier. High impedance amplifiers with carefully designed noise parameters allow fundamental power matching bandwidth limits for small antennas to be bypassed, thereby enabling small, ultra-wideband receivers for size-constrained wireless device applications. The goal is to determine how the noise parameters of the amplifier could be adjusted to minimize noise and maximize bandwidth. (6 pages)
Mobilization of Postoperative Radio-ulnar Synostosis with Vascularized Fascio-fat Graft. A Case Report. (1998)

We report a patient who developed proximal radio-ulnar synostosis after two attempts of open reduction for congenital subluxation of the radial head. The patient was a 5 year-old boy who sustained a supracondylar fracture to his right humerus after a fall.Coincident congenital radial head subluxation was misdiagnosed as traumatic dislocation and he received open reduction of the radial head and pinning. But the radial head subluxated again. He then received a second open reduction with pinning and osteotomy of the ulna. Proximal radio-ulnar synostosis developed after these surgeries. On the first visit to our clinic, he showed ankylosis of forearm in 10° pronation. X-p films and CT revealed proximal radioulnar synostosis. The synostosis was separated and the space created by separation was filled with the anconeus and vascularized fascio-fat graft from the ipsilateral upper arm. Three years after surgery, X-p films showed no re-ankylosis and supination improved to 35° and pronation improved to 45°.
Levamisole and bovine immunity: in vitro and in vivo effects on immune responses to herpesvirus immunization (1981)

Levamisole was shown to enhance in vitro blastogenic responses of bovine lymphocytes to nonspecific mitogens (phytohemagglutinin and pokeweed mitogen) as well as to infectious bovine rhinotracheitis virus and purified protein derivative. Greatest enhancement was observed at suboptimal concentrations of viral antigen. In addition to enhancing lymphocyte reactivity levamisole also affected macrophage activity as determined by increased Fc receptor activity and [3H]glucosamine incorporation. Levamisole (5-50 micrograms/mL) enhanced type II immune (or gamma) interferon production by macrophage-lymphocyte cultures. Administration of levamisole and attenuated infectious bovine rhinotracheitis vaccine virus in vivo did not elevate cellular or humoral responses.
3D Reconstruction by SfM Using Spherical Panoramas and Its Application to Image Based Position-direction Estimation (2015)

In this paper, we propose 3D reconstruction by structure from motion (SfM) using spherical panoramic imagery and its application. The first part starts from describing a brief overview of the proposed SfM and discussing advantages and disadvantages of using panoramic images for SfM. Since the major problem is induced by panoramic image distortion, the proposed SfM overcomes it by feature detection and description with the panoramic image rectification and by evaluating the angular errors in the geometric estimation. In the second part, as an application of 3D reconstruction by the proposed SfM, we propose a system for estimating positions and directions of input query images. To achieve this, we build the geo-located image database by using the camera positions and directions estimated by the proposed SfM. Using this image database, we perform fast query image localization based on tiled BoVW matching. We evaluate the proposed SfM on real image sequences and also evaluate the system of query position and direction estimation.
Making Route Flap Damping Usable (2014)

Route Flap Damping (RFD) was first proposed to reduce BGP churn in
routers. Unfortunately, RFD was found to severely penalize sites for
being well connected because topological richness amplifies the number
of update messages exchanged. Many operators have turned RFD off.
Based on experimental measurement, this document recommends adjusting
a few RFD algorithmic constants and limits in order to reduce the high
risks with RFD. The result is damping a non-trivial amount of long-
term churn without penalizing well-behaved prefixes' normal
convergence process.
Effects of temperature on ileal blood flow and oxygenation (1985)

Arterial pressure, venous outflow pressure, blood flow, and arteriovenous oxygen difference were measured in autoperfused preparations of canine ileum while lumen temperature was altered in 1-5 degrees C increments (or decrements) between 31 and 40 degrees C. Neither blood flow nor vascular resistance was correlated to lumen temperature. However, both arteriovenous oxygen difference and oxygen uptake were linearly correlated with lumen temperature. The relation between ileal oxygen uptake and lumen temperature was consistent with a change in metabolic rate for a 10 degrees C change in temperature (Q10) for oxygen consumption of 2.7. These observations indicate that ambient temperature exerts a profound influence on intestinal oxygen consumption and that variations in temperature may explain the wide range of intestinal oxygen uptake values reported in the literature.
Preserved striatal innervation and motor function despite severe loss of nigral dopamine neurons following mitochondrial dysfunction induced by mtDNA mutations (2023)

Abstract Degeneration of dopamine neurons in the substantia nigra and their striatal axon terminals causes cardinal motor symptoms of Parkinson’s disease (PD). In idiopathic cases, high levels of mitochondrial DNA (mtDNA) mutations associated with mitochondrial dysfunction are a central feature of these vulnerable neurons. Here we present a mouse model expressing the K320E-variant of the mitochondrial helicase Twinkle in dopamine neurons, leading to accelerated mtDNA ageing. K320E-Twinkle DaN mice showed normal motor function at 20 months of age, although already ∼70% of nigral dopamine neurons had perished. The remaining neuron population still preserved ∼75% of axon terminals in the dorsal striatum, which enabled normal dopamine release. Transcriptome analysis and viral tracing confirmed compensatory axonal sprouting of surviving nigral dopamine neurons. We conclude that a small population of substantia nigra neurons can adapt to mtDNA mutations and maintain motor control in mice, holding chances for new treatment strategies in PD patients.
Refining a divisive partitioning algorithm for unsupervised clustering (2003)

Abstract. The Principal Direction Divisive Partitioning (PDDP) algorithm is a fast and scalable clustering algorithm [3]. The basic idea is to recursively split the data set into sub-clusters based on principal direction vectors. However, the PDDP algorithm can yield poor results, especially when cluster structures are not well-separated from one
Polymer dynamics and diffusive properties in ultrathin photoresist films (2003)

A series of experiments are presented to demonstrate thin film confinement effects on the diffusive properties in poly(tert-butoxycarboxystyrene) (PBOCSt). Bilayer diffusion couple measurements reveal that as the thickness of a PBOCSt film is decreased, the kinetics of the deprotection reaction-front propagation (a process involving both the diffusion and reaction of photochemically activated acidic protons) are dramatically hindered. Incoherent neutron scattering measurements suggest that this retardation can be traced to a suppression of local fast relaxations (200 MHz or faster) native to the PBOCSt polymer. The reduced mobility in the thin PBOCSt films is further confirmed with moisture vapor uptake studies performed on a quartz crystal microbalance (QCM). As the film thickness drops below 500 Angstrom there is a strong reduction in the diffusivity of water in the film. In total, these are the first evidences suggesting that the deviations in lithographic performance with decreasing film thickness observed with the bilayer experiments can are due to changes in mobility, not reactivity, within a chemically amplified resist.
Concentration and power dependencies of level population of 2.8-μm laser transition in YLF:Er crystals under cw laser diode pumping (2001)

An influence of inter-ionic cross relaxation processes (up- conversion, self-quenching) on concentration and power dependence's of the inverse population of <SUP>4</SUP>I<SUB>11/2</SUB> and <SUP>4</SUP>I<SUB>13/2</SUB> laser levels in YLF:Er crystals under CW laser-diode pumping were studied both theoretically and experimentally. Computer simulations were carried out taking into account not only pair interaction but also the multi-ion interaction in the whole system. Optimal Er concentration for 3-micrometers CW lasing was estimated as 10- 15%.