gebhart/patrepeval huggingface dataset:
Malignant Struma Ovarii Requiring Emergency Surgery for Acute Abdomen: A Case Report and Literature Review (2020)

Malignant struma ovarii is an extremely rare tumor, accounting for ≤0.1% of all mature cystic teratomas and 0.01% of all ovarian tumors. We herein describe a case involving a patient who underwent emergency surgery for suspected torsion of a mature cystic teratoma that was later diagnosed as malignant struma ovarii. A 23-year-old woman was brought to our hospital with the main complaint of acute lower abdominal pain. Computed tomography revealed a 10-cm-diameter right ovarian tumor with findings suggestive of a mature cystic teratoma. Based on the computed tomography and clinical findings, torsion of the ovarian tumor was suspected; therefore, emergency laparoscopic-assisted surgery was performed. On histopathological examination, the tumor was composed of cells with clear basophilic cytoplasm and a round nucleus. The cells were organized in thyroid follicle-like structures or funicular and solid honeycomb structures, and they exhibited slight nuclear atypia, proliferation, and vascular invasion. The tumor was diagnosed as malignant struma ovarii, and additional surgical resection of the right adnexa with partial omentectomy by laparotomy was performed on a later date. No malignant cells were found in the subsequently resected tissues, and cytologic examination of the ascitic fluid was negative. Because no residual tumor was found, the patient was followed up at the outpatient clinic without additional treatment. No signs of recurrence had been detected at the time of this writing. We herein present this case along with a literature review.
A New Approach to Expand Cord Blood Derived Hematopoietic Stem Cells, Using Bioengineered Human Fetal Liver Tissue 3D-Constructs (2015)

Abstract Despite advances in ex-vivo expansion of cord blood-derived hematopoietic stem/progenitor cells (CB-HSPC), challenges still remain regarding the ability to obtain, from a single unit, sufficient numbers of both long- and short-term repopulating cells, capable of functional engraftment, to enable the treatment of an adolescent or adult patient. We have previously shown that CB-HSPC can be effectively expanded in a 2D serum-free culture system, using a feeder layer of adult human bone marrow-derived stromal cells; still, the percentage of the most primitive stem cells decreased with time. Because, during development, the fetal liver is the main site of HSC expansion and differentiation, we hypothesized that efficient expansion of functional HSPC could be achieved in vitro under more physiologic conditions provided by surrogate fetal liver microenvironments. Therefore, we compared bioengineered liver constructs made from a natural 3D liver extracellular matrix (3DExM) seeded with hepatoblasts (HB), fetal liver-derived stromal cells (FLSC), or bone marrow-derived stromal cells (BMSC), with a 2D culture system using FLSC or BMSC. Overall, 2D culture systems generated a higher yield of mature blood cells by day 14, mostly within the myelomonocytic lineages, with fold increases in total cell number in 2D-HB, 2D-FLSC, and 2D-BMSC cultures of 1145, 16151, and 229, respectively, while 3D cultures generated fold increases of 94.3, 492, and 110, respectively. Nevertheless, the output and expansion of more primitive HSPC was significantly higher in 3D cultures, as determined by flow cytometry and colony-forming assays. Specifically, in 3D-HB cultures, the percentage of CD34+CD38- cells increased by 100% at day 2, while 3D-FLSC and 3D-BMSC cultures each supported a 90% increase in the percentage of CD34+CD38- cells during this period. By contrast, all of the 2D cultures experienced a 30% decrease in the percentage of CD34+CD38- cells during this same time period. In addition, only 3D conditions maintained CD34+CD38- cells until day 12 of culture. Colony-forming assays demonstrated that the CFU-GEMM output was higher in 3D cultures when compared with their 2D counterpart. Among the 3D cultures, the 3D-HB cultures had the highest number of CFU-GEMM at day 2 and day 4. In conclusion, we demonstrate that by integrating biological components in vitro to obtain structures that contain all the necessary elements to mimic the fetal liver microenvironmental niches, which are known to promote rapid expansion of HSC during development, we were able to achieve significant expansion and maintenance of CD34+CD38- cells. In addition, since little is known about fetal liver niches that support HSPC expansion, the 3D constructs will provide, for the first time, a model system in which to dissect the role of the individual cellular and matrix niche components in supporting CB HSPC maintenance, expansion, and differentiation. Disclosures No relevant conflicts of interest to declare.
Long-term follow-up of severely symptomatic women with adenomyoma treated with combination therapy (2013)

Combination therapy for adenomyoma provides an effective treatment option for long-term symptom control and uterine preservation in severely symptomatic women for whom previous long-term drug therapy has failed or proven to be intolerable.
RoboTalk: controlling arms, bases and androids through a single motion interface (2006)

Despite several successful humanoid robot projects from both industry and academia, generic motion interfaces for higher-level applications are still absent. Direct robot driver access proves to be either very difficult due to the complexity of humanoid robots, very unstable due to constant robot hardware upgrade and re-design, or inaccessible due to proprietary software and hardware. Motion interfaces do exist, but these are either hardware-specific designs, or generic interlaces that support very simple robots (non-humanoids). Thus, this paper introduces RoboTalk, a new motion interface for controlling robots. From the ground up our design model considers three factors: mechanism-independence to abstract the hardware from higher-level applications, a versatile network support mechanism to enable both remote and local motion control, and an easy-to-manage driver interface to facilitate the incorporation of features by hardware developers. The interface is based on a motion specification that supports a wide range of robotic mechanisms, from mobile bases such as a Pioneer 2 to humanoid robots. The specification allows us to construct interfaces from basic blocks, such as wheeled bases, robot arms and legs. We have tested and implemented our approach on the Honda ASIMO robot and a Pioneer 2 mobile robot
DESIGN AND SYNTHESIS OF NOVEL TERREMIDE DERIVATIVES FOR PHARMACOLOGICAL EVALUATION (2022)

clinicians and chemists are directed in those days toward the biologically active compounds to reduce the mortality and morbidity. Quinazolines were reported previously as a scaffold that possesses antitumor and antimicrobial activities. Close inspection of the structure-activity-relationships (SAR) of quinazolines revealed important structural features necessary for their antimicrobial activity: a nitrogenous ring and a side chain. Using quinazoline heterocyclic compound to try to synthesize compounds similar to terremide to enhance the activity. In the present work, advantageous moieties have been combined together to generate new hybrid scaffolds of quinazoline with the objective of synthesizing new moieties enhancing the antimicrobial biological activityand drug-like properties.
Low-Sampling-Frequency Stator Flux Linkage Observer for Interior Permanent-Magnet Synchronous Machines (2015)

Deadbeat-direct torque and flux control (DB-DTFC) is a direct torque control (DTC) method that provides the fastest possible torque response with smooth and continuous operation even at the voltage limits. DB-DTFC achieves the smoothest possible torque and flux trajectory tracking performance by using the machine inverse model to select volt-second solutions that will produce the desired torque and flux by the end of each pulsewidth modulation (PWM) interval. Since the DB-DTFC inverse model requires accurate steady-state and dynamic flux estimates, discrete-time stator current and flux linkage observers are needed to properly implement DB-DTFC. The existing high-sampling-frequency stator current and flux linkage observers are formed based on approximate discrete-time models for IPMSMs by assuming high-sampling-frequency (10-kHz) operation. This paper presents a more exact discrete-time model for IPMSMs, such that, even at low sampling frequencies, proper stator current and flux linkage observers can be formed to achieve accurate current and flux linkage estimation. The proposed low-sampling-frequency stator current and flux observers are developed using discrete-time modeling with an inverter-sourced volt-second input model. The proposed observers are shown to be very feasible for real-time implementation, and their experimental evaluation documents the improvement achieved compared to high-sampling-frequency observers, even under machine parameter variations.
Alternative Test Methods for Monitoring the Condition of Brushless Exciters in Synchronous Machines (2022)

Although brushless excitation systems in synchronous machines have reduced the maintenance requirements and brush-related failures, they have increased the operating stresses on the excitation system components. Since the rotating excitation system is not accessible, it is difficult to detect excitation system failures such as open circuit diodes or open armature windings to prevent degradation in machine performance and reliability. Detection of such failures currently relies on monitoring the magnitude and harmonic content of the exciter field current. However, it is desirable to improve the reliability of fault detection with multiple test methods, considering the high cost of brushless exciter testing and repair due to the requirement of machine outage/disassembly. In this work, alternative off-line testing and on-line monitoring options are proposed for detection of excitation system failures. An off-line test based on ac excitation of the exciter field and on-line monitoring based on stator current and airgap flux analysis, are investigated, and fault indicators sensitive to excitation system failures are proposed for reliable fault monitoring. An experimental study on 3.8, 5.5, and 30 kW synchronous machines is given to validate the claims on the sensitivity and reliability of the proposed test methods.
The effect of growth temperature on physical properties of heavily doped ZnO:Al films (2009)

Abstract Heavily‐doped ZnO:Al films have been deposited on high temperature stable glass substrates using radio‐frequency (RF) magnetron sputtering. The effect of growth temperature on physical properties of the films has been investigated. The microstructure evolved a columnar structure into a granular one with the increase in growth temperature and then a typical honeycomb‐type microstructure representing huge grain formation indicating high densification. All Al‐doped ZnO films exhibited high optical transparency and the absorption edge shifted to the short wavelength (blue‐shift) as the growth temperature increased. The dense microstructure with a high crystallographic quality and large grains evolved at 500 °C enabled us to obtain 2.28 × 10 –3 Ω cm and high visible transmittance over 90% even if the ZnO film was doped with an Al content of approximately 5.5 at%. (© 2009 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Multicore fiber for bi-directional transmission (2016)

The optimum structure of MCF for bi-directional transmission was studied. Based on the investigation of core pitch and cladding diameter, 16-core fiber design was found to be the most feasible for the bi-directional transmission system.
Synthesis of [14C] ‐ and [13C6]‐labeled tipranavir and its potential hydroxyl metabolite and the glucuronide conjugate (2008)

Abstract Tipranavir or Aptivus ® is a non‐peptidic protease inhibitor approved for the combination treatment with ritonavir of HIV infection. Tipranavir labeled with radioactive and stable isotopes of carbon was required for drug metabolism (excretion, distribution, and absorption) studies and to develop bioanalytical methods needed for the support of clinical studies. [7‐ 14 C]‐Benzoic acid and uniformly labeled benzoic acid (ring‐ 13 C 6 99 at% 13 C) were used to prepare [ 14 C]‐ and [ 13 C 6 ]‐labeled tipranavir, respectively. Radioactively labeled tipranavir was prepared with a specific activity of 54 mCi/mmol (2GBq/mmol); it was necessary to dilute its specific activity with unlabeled tipranavir to 28 mCi/mmol (46.45 µCi/mg) because of its instability. The N ‐hydroxyl metabolite (12) and the glucuronide conjugate (13), the most abundant metabolites of tipranavir (when administered in conjunction with ritonavir) were also synthesized. Copyright © 2008 John Wiley &amp; Sons, Ltd.
Chemical vapor deposition and atomic layer deposition for advanced lithium ion batteries and supercapacitors (2015)

Recent developments and applications of atomic layer deposition and chemical vapor deposition in energy storage devices are reviewed.
Light reallocation for high contrast projection using an analog micromirror array (2010)

We demonstrate for the first time a proof of concept projector with a secondary array of individually controllable, analog micromirrors added to improve the contrast and peak brightness of conventional projectors. The micromirrors reallocate the light of the projector lamp from the dark parts towards the light parts of the image, before it reaches the primary image modulator. Each element of the analog micromirror array can be tipped/tilted to divert portions of the light from the lamp in two dimensions. By directing these mirrors on an image-dependent basis, we can increase both the peak intensity of the projected image as well as its contrast.
µ-Oxo-bridged diiron(III) complexes and H2O2: monooxygenase- and catalase-like activities (1994)

The µ-oxo-bridged diiron(III) complex [Fe2O(bipy)4(OH2)2][ClO4]41(bipy = 2,2′-bipyridine) was found to exhibit monooxygenase-like activity, using H2O2 as the oxidant. The system oxidizes alkanes to alcohols and ketones quite efficiently (46 mmol of cyclohexanol + cyclohexanone per rnmol complex in 10 min). In the case of adamantane, selectivity for the tertiary hydrogen was indicated by a high normalized C3:C2 ratio of 9:1. The same reaction yields and rates were obtained whether argon or dioxygen was bubbled through the solution. Dimethyl sulfide was transformed into dimethyl sulfoxide and dimethylsulfone and benzene into phenol. These results exclude O2 as a key reactant in this system and suggest that high-valent oxoiron intermediates and hydroxyl radicals are the active species. The potential of this system is strongly limited by the instability of the catalyst and by its strong catalase-like activity. Complex 1 is actually a very efficient catalyst for hydrogen peroxide dismutation, thus transforming 50% of the excess of H2O2 into O2 in 10 min.
Characterization of Thin-Film Electrodes on Proton-Conducting Glass Membranes for Micro DMFC Applications (2008)

Thin film electrodes for a low power direct methanol fuel cell (DMFC) were prepared by incorporating carbon-supported Pt nanoparticles (Pt/C) into a silicon dioxide glass matrix. Scanning electron micrographs (SEM) indicate that the Pt/C was well dispersed. The catalyst islands were interconnected into a conductive sheet by electrolessly depositing platinum from an aqueous plating bath. The Pt/C - SiO2 glass composite thin- film electrodes showed high methanol oxidation peak currents of approximately 180 mA/cm2 in 0.5 M H2SO4, 0.5 M methanol electrolyte. The composite electrode was also applied to the anode of a 1 cm2 passive DMFC and compared to an equivalent passive DMFC with a traditional Nafion®-based Pt anode electrode with 10 M MeOH at room temperature. The new composite electrode DMFC showed a 50 mV higher open circuit voltage than the Nafion electrode cell and the current density was also modestly improved.
Through-the-jacket inscription of fiber Bragg gratings using femtosecond infrared radiation for sensor applications (2009)

Silica-based fiber Bragg gratings (FBG) sensors are versatile devices that are typically fabricated using UV laser exposure. As most standard optical fiber polymer coatings are highly absorbing in the UV, grating inscription typically requires the removal and reapplication of the protective coating by either chemical or mechanical means. Optical fiber stripping and recoating are time-consuming processes that can seriously degrade the mechanical integrity of the fiber. For high temperature sensor applications (&gt; 200 &deg;C), the optical fiber is coated in polyimide which is resistant to chemical attack. Invasive and hazardous techniques for its removal are required such as hot sulphuric acid stripping. In this paper, results of FBG inscription directly through the polymer coating of standard optical fiber with a femtosecond infrared laser and a phase mask are reviewed. Significant grating reflectivities are achieved along with improved mechanical reliability and performance at elevated temperatures. The only example of direct FBG inscription through polyimide coatings for high temperature stable grating sensors will also be presented.
Glucose transport in human skeletal muscle. The in vivo response to insulin (1993)

Transmembrane glucose transport plays a key role in determining insulin sensitivity. We have measured in vivo WBGU, FGU, and K(in) and K(out) of 3-O-methyl-D-glucose in forearm skeletal muscle by combining the euglycemic clamp technique, the forearm-balance technique, and a novel dual-tracer (1-[3H]-L-glucose and 3-O-[14C]-methyl-D-glucose) technique for measuring in vivo transmembrane transport. Twenty-seven healthy, lean subjects were studied. During saline infusion, insulin concentration, FGU (n = 6), K(in), and K(out) (n = 4) were similar to baseline. During SRIF-induced hypoinsulinemia (insulin < 15 pM, n = 4) WBGU was close to 0, and FGU, K(in), and K(out) were unchanged from basal (insulin = 48 pM) values. During insulin clamps at plasma insulin levels of approximately 180 (n = 4), approximately 420 (n = 5), approximately 3000 (n = 4), and approximately 9500 pM (n = 4), WBGU was 14.2 +/- 1.3, 34.2 +/- 4.1 (P < 0.05 vs. previous step), 55.8 +/- 1.8 (P < 0.05 vs. previous step), and 56.1 +/- 6.3 mumol.min-1.kg-1 of body weight (NS vs. previous step), respectively. Graded hyperinsulinemia concomitantly increased FGU from a basal value of 4.7 +/- 0.5 mumol.min-1.kg-1 up to 10.9 +/- 2.3 (P < 0.05 vs. basal value), 26.6 +/- 4.5 (P < 0.05 vs. previous step), 54.8 +/- 4.3 (P < 0.05 vs. previous step), and 61.1 +/- 10.8 mumol.min-1.kg-1 of forearm tissues (NS vs. previous step), respectively.
Hydrolytically stable octahedral silicon complexes as bioactive scaffolds: application to the design of DNA intercalators (2012)

We here introduce octahedral silicon serving as a structural center for the design of hydrolytically stable bioactive complexes as demonstrated with the generation of silicon-based high affinity DNA binders. This proof-of-principle study suggests that octahedral silicon complexes are falsely neglected, promising structural templates for widespread applications in chemical biology and medicinal chemistry.
On the Transversely Isotropic, Hyperelastic Response of Central Nervous System White Matter Using a Hybrid Approach (2020)

Abstract A numerical and experimental hybrid approach is developed to study the constitutive behavior of the central nervous system white matter. A published transversely isotropic hyperelastic strain energy function is reviewed and used to determine stress–strain relationships for three idealized, simple loading scenarios. The proposed constitutive model is simplified to a three-parameter hyperelastic model by assuming the white matter's incompressibility. Due to a lack of experimental data in all three loading scenarios, a finite element model that accounts for microstructural axons and their kinematics is developed to simulate behaviors in simple shear loading scenarios to supplement existing uniaxial tensile test data. The parameters of the transversely isotropic hyperelastic material model are determined regressively using the hybrid data. The results highlight that a hybrid numerical virtual test coupled with experimental data, can determine the transversely isotropic hyperelastic model. It is noted that the model is not limited to small strains and can be applied to large deformations.
The PR55 and PR65 subunits of protein phosphatase 2A from Xenopus laevis. Molecular cloning and developmental regulation of expression (1995)

International audience
Characterization of red-green and yellow-blue opponent channels (2004)

Purpose: Responses of opponent-channels have been modeled in the past as a linear transformation of cone absorption values L,M,S (and of tristimulus values CIEXYZ). Different authors proposed different linear transformations. We asked two related questions: (i) which of these transformations is psychologically most plausible; (ii) is a linear transformation the right model, in the first place. Linear transformations have commonly been considered acceptable in view of substantial individual differences with respect to the position of pure hues. To shed more light on the two questions, we tested positions of pure colors for individual subjects. Methods: The subject viewed a patch in the center of a calibrated CRT monitor with neutral gray background. The subject's task was to adjust the intensity of one gun so that the patch looked as having pure color (red, green, blue or yellow). The starting hue of the patch was produced by a weighted combination of the other two guns. By changing the weights of the two guns, the experimenter manipulated the saturation of the final adjustment. Each of the five subjects ran four sessions (one session per hue), 10 trials per session. Results: Neither of the two opponent channels can be adequately approximated by a single straight line. The red-green channel can be approximated by two straight lines, forming an angle that did not vary much across subjects. The yellow-blue channel can be approximated by a quadratic function, whose middle section coincides closely with the daylight locus. Conclusions: Linear transformation of cone responses (or of tristimulus values) does not seem to be an adequate model for describing the characteristics of opponent channels. Furthermore, it does not seem that any simple non-linear transformations could be an adequate model, either.
Collaborative Orchestration of Multi-Domain Edges From a Connected, Cooperative and Automated Mobility (CCAM) Perspective (2021)

The 5G ecosystem is comprised of the cellular 5G System, as well as a managed and orchestrated infrastructure providing virtualized network and service functions. The automotive industry with its stringent requirements for connected vehicles is a promising and yet challenging consumer of such 5G ecosystem. Deployment of service instances at distributed cloud resources of cellular network infrastructure edges enables localized low-latency access to these services from moving vehicles but comes along with challenges, such as the need for fast reconfiguration of the distributed deployment according to mobility pattern and associated service and resource demand. In this paper, we investigate a solution for the collaborative orchestration of services for Connected, Cooperative and Automated Mobility (CCAM) within such 5G ecosystem. A key objective is the service continuity for a highly dynamic automotive scenario, achieved by the associated management and orchestration of these services in distributed edge clouds. The proposed solution leverages a multi-tier orchestration system as well as localized management and protocol operations for collaborative edge resources. By means of both analytical and experimental evaluations, the paper draws conclusions on the gain in accelerating orchestration decisions and enforcements, while balancing associated protocol and computational load over the highly distributed and multi-layered orchestration system.