gebhart/patrepeval huggingface dataset:
The Relationship Between Internet Addiction and General Health in Students of Hamadan University of Medical Sciences-Iran, 2015: A Cross Sectional Study (2016)

Objectives: The Internet is a global system that is increasingly used by the public, especially university students, as a useful tool to access information sources. The aim of this study was to investigate the relationship between Internet addiction and general health in students of Hamadan University of Medical Sciences, during year 2015. Methods: This cross-sectional study was conducted on 650 students of Hamadan University of Medical Sciences, west of Iran, during year 2015. The participants were volunteers and were selected by stratified sampling. The data collection tool was the Young internet addiction test and general health questionnaire (GHQ28). Data was analyzed by logistic regression and analysis of variance methods. Results: Mean age of students was 22 Â± 4.01 years old. The mean score of Internet addiction was 77.08 Â± 17.24 and mean score of general health was 59.38 Â± 9.54. Analysis of variance method showed that the score of all general health aspects (except social functioning) was increased significantly in the addicted group in comparison with normal and suspected groups (all Ps < 0.001). In addition, risk of internet addiction in females was 1.81 (95% CI: 1.3 - 2.5) times more than males. Pearson correlation coefficients showed that internet addiction score increased in the same direction as all general health aspects (all P < 0.001). Conclusions: Results showed that overuse of the Internet is causing serious problems for general health in students of medical universities.
Robot-assisted Laparoscopic Radical Prostatectomy: Clinical Experience of 200 Cases (2008)

PURPOSE: We report the initial functional and surgical results of 200 robot-assisted laparoscopic radical prostatectomies performed at our hospital, and evaluate the efficacy and safety of this surgery. MATERIALS AND METHODS: Between July 2005 and July 2007, 200 patients underwent robot-assisted laparoscopic radical prostatectomy(RLRP). All cases were performed using the four-arm da Vinci(TM) robot system (Intuitive Surgical, Mountain View, CA USA). RLRP was performed by two surgeons. All operations were approached transperitoneally. We studied the perioperative parameters and early surgical outcome retrospectively. RESULTS: The mean age at surgery was 64+/-8.2 years. The median preoperative prostate-specific antigen level was 8.24 ng/ml(range, 1.37-726.60 ng/ml) and the mean preoperative Gleason score was 6.5(range, 4-9). The median total operative time was 215 min(range, 140-418 min) and the median estimated blood loss was 300ml(range, 50-2,700ml). A positive surgical margin was found in 64 patients(32.0%). A normal diet was started 2.3 days after surgery and the median hospital stay was 5 days(range, 2-26 days). Among 71 patients with over 6 months follow-up, 69 patients (97.2%) were completely continent at 6 months after surgery and 29 patients(40.8%) were completely continent at catheter removal. In 58 patients who were younger than 65 years, potent preoperatively, and received a nerve sparing procedure, 31 patients(53.4%) were potent at 6 months after surgery. CONCLUSIONS:We were able to verify the feasibility and safety of RLRP in the management of prostate cancer. A longer follow-up of the data and larger prospective studies are necessary to confirm these results
Analysis of Sr5-xBax(PO4)3F:Yb3+ crystals for improved laser performance with diode-pumping (1997)

Crystals of Yb3+:Sr5-xBax(PO4)3F (0 ≤ × ≤ 5) have been investigated as a means to obtain broader absorption bands than are currently available with Yb3+:S-FAP [Yb3+:Sr5(PO4)3F], thereby improving diode-pumping efficiency for high peak power applications. Large diode-mays have a FWHM pump band of ≥5 nm while the FWHM of the 900 nm absorption band for Yb:S-FAP is 5.5 nm; therefore, a significant amount of pump power can be wasted due to the nonideal overlap. Spectroscopic analysis of Yb:Sr5-xBax-FAP crystals indicates that adding barium to the lattice increases the pump band to 13-16 nm which more than compensates for the diode-array pump source without a detrimental reduction in absorption cross section. However, the emission cross section decreases by approximately half with relatively no effect on the emission lifetime. The small signal gain has also been measured and compared to the parent material Yb:S-FAP and emission cross sections have been determined by the method of reciprocity, the Füchtbauer-Ladenburg method, and small signal gain. Overall, Yb3+:Sr5-x Bax(PO4)3F crystals appear to achieve the goal of nearly matching the favorable thermal and laser performance properties of Yb:S-FAP while having a broader absorption band to better accommodate diode pumping.
MR&D: The conference, 2009 (2009)

The inaugural Molecular Reproduction & Development conference was held at Brown University on March 26 th -28 th , 2009.The conference consisted of six sessions, ranging from molecular mechanisms of the oocyte-to-embryo transition, to environmental impact on oocyte quality, to computational analysis of the evolution of genes involved in reproduction.Over 75 attendants, including basic researchers, clinicians, and students, held lively discussions after each talk so that the group as a whole advanced the fi eld with new models and creative approaches to test predictions.Compiled below are highlights from the Editors' comments on the conference.
Persistence of Diminished Bone Mineral Content Following Renal Transplantation in Childhood (1984)

Bone mineral content (BMC) was measured in the nondominant arm of 18 children (aged 3 7/12 to 17 1/2 years) for a total 783 months after renal transplantation. Using photon absorptiometry, 89 measurements were made; 17 of the 18 patients had a functioning graft and one patient died. Significant demineralization, a BMC greater than -2 SD below appropriate control volumes, was found in 11 of 18 patients (62%) and 55 of 89 measurements (61%). Bone loss was progressive; among the 16 patients followed for more than 6 months, ten showed a decline of more than 0.5 SD in BMC, five had no change, and only one showed improvement. No relationship was found between BMC and the use of furosemide, type of transplant (15 living, seven cadaver), prior renal disease (six with glomerulonephritis, 11 tubulointerstitial), need for a second graft (five patients), chronic anticonvulsant therapy, or serum calcium and phosphate values. BMC was slightly correlated (P less than .05) with alkaline phosphatase values. BMC was more strongly correlated with serum creatinine (y = -0.48x + 1.25, r = -.042, P less than .001) and prednisone dose (mg/kg/d) (y = -0.65x + 0.481, r = -.543, P less than .001) in an inverse relationship. Patients whose serum creatinine value was less than 1 mg/dL had a BMC of -0.71 +/- 0.34 SD; those with serum creatinine value greater than 2 mg/dL had BMC of -3.32 +/- 0.31 SD, different at P less than .001. Patients receiving daily prednisone therapy had a significantly lower BMC than those receiving alternate-day therapy (-3.11 +/- 1.23 SD v -1.72 +/- 1.29 SD, P less than .005).(ABSTRACT TRUNCATED AT 250 WORDS)
Successful extubation of neonates (1981)

Arterial blood gases, pulmonary mechanics, lung volume measurements and clinical profiles were determined pre and postextubation in 19 infants recovering from respiratory disease. This study evaluated clinical and physiological factors which may be valuable in predicting successful extubation in neonates. Of the 19 patients, 4 required reintubation within 72 h. In this group of patients, the combined profile of low birth weight (1050 g), low gestational age (31 weeks), and high pulmonary resistance (inspiratory 278 cm H2O/L · sec, expiratory 309 cm H2O/L · sec) was significantly different from the 15 patients who were successfully extubated. In addition, lower pHa after extubation was also characteristic of those infants requiring reintubation.
Characterizing the High Disease Burden of Transthyretin Amyloidosis for Patients and Caregivers (2018)

Pfizer.
ChemInform Abstract: Rhodium‐Catalyzed Transnitrilation of Aryl Boronic Acids with Dimethylmalononitrile. (2016)

Abstract This method represents a novel approach for the preparation of aryl nitriles by using a carbon‐bound cyanating reagent which undergoes cross‐coupling with aryl boronic acids.
User-Generated Services Composition in Smart Multi-User Environments (2017)

The increasing complexity shown in Smart Environments, together with the spread of social networks, is increasingly moving the role of users from simple information and services consumers to actual producers. In this work, we focus on security issues raised by a particular kind of services: those generated by users. User-Generated Services (UGSs) are characterized by a set of features that distinguish them from conventional services. To cope with UGS security problems, we introduce three different policy management models, analyzing benefits and drawbacks of each approach. Finally, we propose a cloud-based solution that enables the composition of multiple UGSs and policy models, allowing users’ devices to share features and services in Internet of Things (IoT) based scenarios.
Asymmetric Synthesis Utilizing Circularly Polarized Light Mediated by the Photoequilibrium of Chiral Olefins in Conjunction with Asymmetric Autocatalysis. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Kerr-lens mode-locked Ho:YAG thin-disk oscillator at 2.1 μm (2017)

Summary form only given. High power ultrafast laser sources at 2 μm are highly desirable as primary sources in many fields such as mid-IR generation, remote sensing, Lidar systems, and medical use. Ho:YAG is an excellent gain crystal for such kind of sources due to its low quantum defect, good crystal quality and broad emission bandwidth. To date, Ho:YAG has been utilized in q-switched and actively mode-locked systems [1, 2]. Very recently passive mode locking has also been demonstrated using semiconductor saturable absorber mirrors (SESAMs) [3, 4]. However, the output power and pulse duration were limited to only several hundred milliwatts and few picoseconds, respectively. Since the invention of thin disk technology, great progress has been made in power and energy scaling of thin disk lasers mode-locked by both SESAM and Kerr-lens mode locking (KLM) [5, 6]. However, KLM shows great advantages compared to SESAM mode-locking in generating shorter pulses with high power due to its fast response time, broad bandwidth operation and higher damage threshold. Here we present a KLM Ho:YAG thin disk oscillator working at 2.1 μm for the first time. It delivers 220 fs pulses with average power up to 20 W, which is, to the best of our knowledge, the shortest pulse duration ever obtained in a Ho:YAG oscillator and highest average power of any mode locked ultrafast oscillator in 2 μm range.
GATA2 as a potential metastasis-driving gene in prostate cancer (2014)

Effective treatment for metastatic prostate cancer is critically needed. The present study was aimed at identifying metastasis-driving genes as potential targets for therapy (oncotargets). A differential gene expression profile of metastatic LTL-313H and non-metastatic LTL-313B prostate cancer tissue xenografts, derived from one patient's specimen, was subjected to integrative analysis using the Ingenuity Upstream Regulator Analysis tool. Six candidate master regulatory genes were identified, including GATA2, a gene encoding a pioneer factor, a special transcription factor facilitating the recruitment of additional transcription factors. Elevated GATA2 expression in metastatic prostate cancer tissues correlated with poor patient prognosis. Furthermore, GATA2 gene silencing in human prostate cancer LNCaP cells led to a marked reduction in cell migration, tissue invasion, focal adhesion disassembly and to a dramatic change in cell transcriptomes, indicating that GATA2 plays a critical role in prostate cancer metastasis. As such, GATA2 could represent a prostate cancer metastasis-driving gene and a potential target for therapy of metastatic prostate cancer.
High-Frequency Absorption-FIFO Pipelining for Stratix 10 HyperFlex (2018)

FPGAs often have significantly lower clock frequencies than microprocessors and GPUs, due largely to propagation delays incurred by the reconfigurable interconnect. The Stratix 10 HyperFlex architecture reduces this problem by embedding numerous registers throughout the routing resources. However, such Hyper-Registers do not support back-pressure (i.e., pipeline stalls) that is commonly used in FPGA pipelines. In this paper, we present and evaluate pipeline transformations using absorption FIFOs, which avoid back-pressure limitations to enable numerous pipelines to benefit from HyperFlex, while also eliminating potentially expensive stall penalties incurred by existing techniques. We demonstrate that these transformations not only enable significant clock improvements on Stratix 10, but also for devices without HyperFlex, potentially making absorption FIFOs a better high-frequency strategy for any FPGA.
Advances in heteroepitaxial integration of III-V and IV-VI semiconductors with electron channeling contrast imaging (2021)

Understanding the behavior of crystal defects like dislocations remains key to successfully integrating dissimilar semiconductors for new paradigms in electronics and photonics. Dissimilarities in compound semiconductors arise not only from a mismatch in the lattice parameter but also thermal expansion, crystal structure, or bonding and these differences must be mediated effectively to control the formation of crystal defects. Dislocations degrade the properties of semiconductors and have thwarted attempts to directly grow III-V telecom lasers on silicon CMOS circuits as they facilitate rapid degradation. [1] Likewise, dislocations reduce the efficiency and performance of infrared detectors grown on highly mismatched substrates. [2] Yet, thanks to an improved understanding of dislocations through microscopy, we continue to learn about their unique properties and uncover new ways to manage them to realize the vision of heterogeneous integration. We describe three examples from our work where non-destructive electron channeling contrast imaging (ECCI), a technique refined more than two decades ago
Stereochemistry of sulfur compounds. II. New reactions at chiral sulfur that complete the first monoligostatic stereochemical reaction cycle (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereochemistry of sulfur compounds. II. New reactions at chiral sulfur that complete the first monoligostatic stereochemical reaction cycleTodd R. Williams, Abraham Nudelman, Robert E. Booms, and Donald J. CramCite this: J. Am. Chem. Soc. 1972, 94, 13, 4684–4691Publication Date (Print):June 1, 1972Publication History Published online1 May 2002Published inissue 1 June 1972https://doi.org/10.1021/ja00768a041Request reuse permissionsArticle Views322Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
A Quantum Algorithm for Finding $k$-Minima (2019)

We propose a new finding $k$-minima algorithm and prove that its query complexity is $\mathcal{O}(\sqrt{kN})$, where $N$ is the number of data indices. Though the complexity is equivalent to that of an existing method, the proposed is simpler. The main idea of the proposed algorithm is to search a good threshold that is near the $k$-th smallest data. Then, by using the generalization of amplitude amplification, all $k$ data are found out of order and the query complexity is $\mathcal{O}(\sqrt{kN})$. This generalization of amplitude amplification is also not well discussed and we briefly prove the query complexity. Our algorithm can be directly adapted to distance-related problems like $k$-nearest neighbor search and clustering and classification. There are few quantum algorithms that return multiple answers and they are not well discussed.
The HCK/BTK inhibitor KIN-8194 is active in MYD88-driven lymphomas and overcomes mutated BTKCys481 ibrutinib resistance (2021)

Activating mutations in MYD88 promote malignant cell growth and survival through hematopoietic cell kinase (HCK)-mediated activation of Bruton tyrosine kinase (BTK). Ibrutinib binds to BTKCys481 and is active in B-cell malignancies driven by mutated MYD88. Mutations in BTKCys481, particularly BTKCys481Ser, are common in patients with acquired ibrutinib resistance. We therefore performed an extensive medicinal chemistry campaign and identified KIN-8194 as a novel dual inhibitor of HCK and BTK. KIN-8194 showed potent and selective in vitro killing of MYD88-mutated lymphoma cells, including ibrutinib-resistant BTKCys481Ser-expressing cells. KIN-8194 demonstrated excellent bioavailability and pharmacokinetic parameters, with good tolerance in rodent models at pharmacologically achievable and active doses. Pharmacodynamic studies showed sustained inhibition of HCK and BTK for 24 hours after single oral administration of KIN-8194 in an MYD88-mutated TMD-8 activated B-cell diffuse large B-cell lymphoma (ABC DLBCL) and BCWM.1 Waldenström macroglobulinemia (WM) xenografted mice with wild-type BTK (BTKWT)- or BTKCys481Ser-expressing tumors. KIN-8194 showed superior survival benefit over ibrutinib in both BTKWT- and BTKCys481Ser-expressing TMD-8 DLBCL xenografted mice, including sustained complete responses of >12 weeks off treatment in mice with BTKWT-expressing TMD-8 tumors. The BCL_2 inhibitor venetoclax enhanced the antitumor activity of KIN-8194 in BTKWT- and BTKCys481Ser-expressing MYD88-mutated lymphoma cells and markedly reduced tumor growth and prolonged survival in mice with BTKCys481Ser-expressing TMD-8 tumors treated with both drugs. The findings highlight the feasibility of targeting HCK, a key driver of mutated MYD88 pro-survival signaling, and provide a framework for the advancement of KIN-8194 for human studies in B-cell malignancies driven by HCK and BTK.
Abstract S4-1: FinXX Final 5-Year Analysis: Results of the Randomised, Open-Label, Phase III Trial in Medium-to-High Risk Early Breast Cancer (2010)

Abstract Background: The randomised, phase III FinXX trial (NCT00114816) investigated whether the integration of capecitabine (X) into a sequential docetaxel (T)→cyclophosphamide + epirubicin + 5-FU (CEF) adjuvant regimen might improve clinical outcome for patients with medium-to-high risk early breast cancer. The planned interim analysis after a median follow-up of 3 years found a significant recurrence-free survival (RFS) benefit with the X-containing regimen versus control (3-year RFS rate: 93% XTP→ukkalaCEX vs 89% T→CEF; hazard ratio 0.66 [95% CI: 0.47-0.94]; p=0.020) [Lancet Oncol 2009;10:1145-51]. Here we present final 5-year RFS data, the primary endpoint of the study. Methods: Eligible patients were aged 18-65 years, had a WHO performance status of 0 or 1 and histologically confirmed invasive breast cancer at medium-to-high risk of recurrence, defined as regional node-positive disease or node-negative disease with primary tumour diameter greater than 20mm and negative progesterone receptor assay. Previous neoadjuvant chemotherapy was not permitted. Patients were randomised in a 1:1 ratio to receive 3 cycles of T→3 cycles of CEF (T→CEF; T 80mg/m2 d1, q3w→C 600mg/m2 d1, E 75mg/m2 d1, F 600mg/m2 d1, q3w) or 3 cycles of XT→3 cycles of CEX (XT→CEX; X 900mg/m2 bid d1-15 + T 60mg/m2 d1, q3w→C 600mg/m2 d1, E 75mg/m2 d1, X 900mg/m2 bid d1-15, q3w). The primary endpoint was RFS, defined as the time from randomisation to the first time the patient is recorded as having disease recurrence or the date of death if the patient dies due to causes other than disease recurrence; secondary endpoints were overall survival and safety. Results: Between January 2004 and May 2007, 1,500 women from Finland and Sweden were randomised to T→CEF (n=747) or XT→CEX (n=753). Final analysis of the primary endpoint will be presented after a median follow-up of 5 years and approximately 200 events. Data are expected in October 2010. Conclusions: The FinXX trial was the first to report the efficacy and safety of X in combination with anthracycline/taxane-containing therapy in the adjuvant treatment of early breast cancer. Final efficacy data are expected in October 2010. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr S4-1.
High Energy Electron Beam Imaging by Silicon Diode Array Target Vidicon (1971)

Siターゲットビジコンの高エネルギー電子線に対する量子効率の解析を行ない, また厚さの異なるターゲットを試作して電子顕微鏡を用いてその特性を測定した.電子線エネルギー200～1000keVの範囲で, 3000～9000という高い電流利得を観測した.解析結果から半定量的ではあるが, 測定結果を説明できることを確かめた.
Purified and Recombinant Hemopexin: Protease Activity and Effect on Neutrophil Chemotaxis (2016)

Infusion of the heme-binding protein hemopexin has been proposed as a novel approach to decrease heme-induced inflammation in settings of red blood cell breakdown, but questions have been raised as to possible side effects related to protease activity and inhibition of chemotaxis. We evaluated protease activity and effects on chemotaxis of purified plasma hemopexin obtained from multiple sources as well as a novel recombinant fusion protein Fc-hemopexin. Amidolytic assay was performed to measure the protease activity of several plasma-derived hemopexin and recombinant Fc-hemopexin. Hemopexin was added to the human monocyte culture in the presence of lipopolysaccharides (LPS), and also injected into mice intravenously (i.v.) 30 min before inducing neutrophil migration via intraperitoneal (i.p.) injection of thioglycolate. Control groups received the same amount of albumin. Protease activity varied widely between hemopexins. Recombinant Fc-hemopexin bound heme, inhibited the synergy of heme with LPS on tumor necrosis factor (TNF) production from monocytes, and had minor but detectable protease activity. There was no effect of any hemopexin preparation on chemotaxis, and purified hemopexin did not alter the migration of neutrophils into the peritoneal cavity of mice. Heme and LPS synergistically induced the release of LTB4 from human monocytes, and hemopexin blocked this release, as well as chemotaxis of neutrophils in response to activated monocyte supernatants. These results suggest that hemopexin does not directly affect chemotaxis through protease activity, but may decrease heme-driven chemotaxis and secondary inflammation by attenuating the induction of chemoattractants from monocytes. This property could be beneficial in some settings to control potentially damaging inflammation induced by heme.
Per-Pixel Divisions (2002)

Abstract We describe a method to perform per-pixel divisions using graphics hardware, with a simple iterative algorithm. In the worst case, the number of rendering passes is 17 for approximate divisions, and 18 for accurate divisions. The algorithm can be used for 3D vector normalization, evaluating complex lighting models, and image reconstruction.