gebhart/patrepeval huggingface dataset:
T-CELL ACTIVATION RESPONSE TO ALLOGENEIC CMV-INFECTED ENDOTHELIAL CELLS IS NOT PREVENTED BY GANCICLOVIR OR FOSCARNET: IMPLICATIONS FOR TRANSPLANT VASCULAR SCLEROSIS12 (2002)

Results of these experiments suggest that although these drugs limit CMV replication and dissemination, they do not attenuate the inflammatory potential of infected EC, a force that may be a major factor in CMV-mediated exacerbation of the development of TVS.
Intrachain disulphide bridges in immunoglobulin G heavy chains. The Fc fragment (1968)

The disulphide bridges of the Fc fragment (C-terminal half of the heavy chain) have been studied in several human immunoglobulins, containing heavy chains of different antigenic types (gamma1, gamma2, gamma3 and gamma4), and in heavy-chain-disease proteins. Two intrachain disulphide bridges were found to be present. The sequences appear to be identical in the Fc fragments of two types of chain studied (gamma1 and gamma3), and very similar to corresponding sequences of the Fc fragment in rabbit. These results suggest that the C-terminal half of the heavy chains is covalently folded (in a similar fashion to the light chains) with a C-terminal loop and an N-terminal loop. The similarity is emphasized by comparison of the sequence and location of the disulphide-bridged peptides of the C-terminal loop of heavy and light chains. The N-terminal loop, on the other hand, appears to be very different in Fc fragments and light chains. The C-terminal loop is the only one present in the F'c fragment.
In-situ digital image correlation and thermal monitoring in directed energy deposition additive manufacturing (2021)

As in welding, directed energy deposition (DED) additive manufacturing (AM) generates complex residual stresses and distortions commensurate with the complexity of the scan pattern used for deposition. To date, measuring DED distortions on complex geometries has only been achieved post process, discarding the complex thermomechanical history that leads to that final material state. In this work, surround stereo digital image correlation (DIC) is used to 3D map surfaces and strain tensors in-situ in a powder-blown laser DED system. Infrared thermography is then projected onto these surfaces to record the full thermomechanical history of printed parts. DIC presents a unique challenge to DED AM, as no part exists at the beginning of deposition, which (a) prevents application of an appropriate speckle pattern and (b) denies the user a zero strain reference frame. Solutions to these problems are proposed and their limitations explored herein. In sum, this work presents a relatively low-cost solution to monitoring and optimizing the unique temporal artifacts induced by complex scan strategies that was previously unobtainable.
Magnetic Properties on FeAl Stripes and Dots Induced by Nanosecond Pulsed Laser Irradiation (2014)

We investigate magnetic properties of FeAl stripes and dots formed on the surface of Fe52Al48 induced by nanosecond pulsed laser irradiation. According to the in-plane magneto-optical Kerr effect (MOKE) measurements, the magnetization reversal in FeAl stripes can be explained by the domain-wall (DW) motion model, indicating that the magnetization rotates incoherently. In contrast, the in-plane and polar MOKE measurements reveal that the magnetic easy axis of the FeAl dots exists along the out-of-plane direction and the coercive force Hc shows as large as 1 kOe. These results indicate that the nanosecond pulsed laser irradiation can be expected to serve as a useful tool for obtaining magnetic nanostructures and creating high-Hc materials.
The Deep Space Quantum Link: Prospective Fundamental Physics Experiments using Long-Baseline Quantum Optics (2021)

The National Aeronautics and Space Administration's Deep Space Quantum Link mission concept enables a unique set of science experiments by establishing robust quantum optical links across extremely long baselines. Potential mission configurations include establishing a quantum link between the Lunar Gateway moon-orbiting space station and nodes on or near the Earth. In this publication, we summarize the principal experimental goals of the Deep Space Quantum Link mission. These include long-range teleportation, tests of gravitational coupling to quantum states, and advanced tests of quantum nonlocality.
Reaction of (aminocarbene)iron complexes with alkynes. A synthesis of 5-aminofurans (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of (aminocarbene)iron complexes with alkynes. A synthesis of 5-aminofuransM. F. Semmelhack and Jaiwook ParkCite this: Organometallics 1986, 5, 12, 2550–2552Publication Date (Print):December 1, 1986Publication History Published online1 May 2002Published inissue 1 December 1986https://pubs.acs.org/doi/10.1021/om00143a025https://doi.org/10.1021/om00143a025research-articleACS PublicationsRequest reuse permissionsArticle Views211Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
En Flandre, une francisation forcée (2015)

info:eu-repo/semantics/published
ChemInform Abstract: Production, Mass Spectroscopy, and Thermal Properties of Fullerenes (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
“New Motions of the Flesh” (2018)

This chapter considers the intertwined cultural resonances of chocolate and fiction, as well as the meaning of chocolate in the developing novel – particularly as it connected to sex and class. It also considers the integral function of chocolate in one novel: Samuel Richardson's Pamela by some estimation the first English novel and by the majority of estimations among the most important. Just as Richardson directs the concupiscent tendencies of fiction to a virtuous goal, chocolate, in Richardson, directs sexual excitement to its right use: namely, the sublimation of sexual pleasure to good moral ends, such as wifely duties and the generation of progeny. Chocolate's amatory associations allowed the novel to use it as shorthand for sexuality. As with sex, Pamela carefully manages the class connotations of chocolate, capitalizing on its luxe associations while also stripping it of degeneracy. Chocolate in Pamela signalizes luxury, refinement, and a brave new world of upper-class consumption.
Diversity of 5'-termini in mRNA of SV40 deletion mutant dl-1811 [proceedings]. (1979)

Senator Bristow appreciates Theodore Roosevelt mentioning Bristow's proposed constitutional amendments in a recent speech. Bristow reviews the two bills he has been working on, one for the industrial commission and the other for the direct election of postmasters.
LEED: A Lightwave Energy-Efficient Datacenter (2019)

A Lightwave Energy-Efficient Datacenter (LEED) is described that consists of: 1) A novel optically-switched datacenter architecture, 2) a Rotor optical switch that can reconfigure a network topology in less than 20 microseconds, and 3) Enhanced link margin burst-mode interconnects that can accommodate an optical switch without the need for optical amplification.
Continuous flow vortex fluidic production of biodiesel (2014)

Vortex fluidic synthesis of biodiesel from sunflower oil under continuous flow at room temperature, with spontaneous phase separation.
ChemInform Abstract: Synthesis of Racemic myo‐Inositol 1,4,5‐Trisphosphate 3‐O‐ Methylenecarboxylate (VII), a Ca2+‐Mobilising myo‐Inositol 1,3,4,5‐ Tetrakisphosphate Analogue. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Tutorial on Clique Problems in Communications and Signal Processing (2020)

Since its first use by Euler on the problem of the seven bridges of Königsberg, graph theory has shown excellent abilities in solving and unveiling the properties of multiple discrete optimization problems. The study of the structure of some integer programs reveals equivalence with graph theory problems making a large body of the literature readily available for solving and characterizing the complexity of these problems. This tutorial presents a framework for utilizing a particular graph theory problem, known as the clique problem, for solving communications and signal processing problems. In particular, this article aims to illustrate the structural properties of integer programs that can be formulated as clique problems through multiple examples in communications and signal processing. To that end, the first part of the tutorial provides various optimal and heuristic solutions for the maximum clique, maximum weight clique, and ${k}$ -clique problems. The tutorial, further, illustrates the use of the clique formulation through numerous contemporary examples in communications and signal processing, mainly in maximum access for nonorthogonal multiple access networks, throughput maximization using index and instantly decodable network coding, collision-free radio-frequency identification networks, and resource allocation in cloud-radio access networks. Finally, the tutorial sheds light on the recent advances of such applications, and provides technical insights on ways of dealing with mixed discrete-continuous optimization problems.
Accelerating Inference of Convolutional Neural Networks Using In-memory Computing (2021)

In-memory computing (IMC) is a non-von Neumann paradigm that has recently established itself as a promising approach for energy-efficient, high throughput hardware for deep learning applications. One prominent application of IMC is that of performing matrix-vector multiplication in <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>O</mml:mi></mml:mrow> <mml:mrow><mml:mo>(</mml:mo> <mml:mrow><mml:mn>1</mml:mn></mml:mrow> <mml:mo>)</mml:mo></mml:mrow> </mml:math> time complexity by mapping the synaptic weights of a neural-network layer to the devices of an IMC core. However, because of the significantly different pattern of execution compared to previous computational paradigms, IMC requires a rethinking of the architectural design choices made when designing deep-learning hardware. In this work, we focus on application-specific, IMC hardware for inference of Convolution Neural Networks (CNNs), and provide methodologies for implementing the various architectural components of the IMC core. Specifically, we present methods for mapping synaptic weights and activations on the memory structures and give evidence of the various trade-offs therein, such as the one between on-chip memory requirements and execution latency. Lastly, we show how to employ these methods to implement a pipelined dataflow that offers throughput and latency beyond state-of-the-art for image classification tasks.
Imaging Liver Lesions Using Grating-Based Phase-Contrast Computed Tomography with Bi-Lateral Filter Post-Processing (2014)

X-ray phase-contrast imaging shows improved soft-tissue contrast compared to standard absorption-based X-ray imaging. Especially the grating-based method seems to be one promising candidate for clinical implementation due to its extendibility to standard laboratory X-ray sources. Therefore the purpose of our study was to evaluate the potential of grating-based phase-contrast computed tomography in combination with a novel bi-lateral denoising method for imaging of focal liver lesions in an ex vivo feasibility study. Our study shows that grating-based phase-contrast CT (PCCT) significantly increases the soft-tissue contrast in the ex vivo liver specimens. Combining the information of both signals--absorption and phase-contrast--the bi-lateral filtering leads to an improvement of lesion detectability and higher contrast-to-noise ratios. The normal and the pathological tissue can be clearly delineated and even internal structures of the pathological tissue can be visualized, being invisible in the absorption-based CT alone. Histopathology confirmed the presence of the corresponding findings in the analyzed tissue. The results give strong evidence for a sufficiently high contrast for different liver lesions using non-contrast-enhanced PCCT. Thus, ex vivo imaging of liver lesions is possible with a polychromatic X-ray source and at a spatial resolution of ∼100 µm. The post-processing with the novel bi-lateral denoising method improves the image quality by combining the information from the absorption and the phase-contrast images.
Pathology and Pathogenesis of Bacterial Infections (2014)

Bacterial pathogens induce potent innate and adaptive immune responses, which, in the majority of situations, are able to eradicate an infection. Extracellular and intracellular bacterial pathogens induce different types of immune responses and have varying strategies for evading the host immune responses. This chapter on pathology and pathogenesis of bacterial infections summarizes the different types and mechanisms of pathology caused by bacteria once they cross mucosal or cutaneous barriers, and either multiply in extracellular spaces or take up residence within host cells. It illustrates how different types of immune responses can cause a variety of pathological damage to the host. The complement system is composed of over 20 different proteins and can be activated directly by extracellular bacteria in multiple ways. The interactions of chemokines and their receptors are critical for the recruitment of neutrophils and monocytes and the inflammatory response to infection. Mycobacterium tuberculosis is the most important chronic bacterial infection in humans, and is responsible for 9 million cases of TB and 1.9 million deaths annually. Extensive studies have identified the surface M protein as the major GAS protein, which stimulates cross-reactive T-cell response.
Additional obstacles in carbon nanotube growth by gas-flow directed chemical vapour deposition unveiled through improving growth density (2019)

Here, we demonstrate an approach of increasing the density of ultralong carbon nanotube (CNT) growth by combining a fast-heating method developed by Huang <i>et al.</i> (<i>J. Am. Chem. Soc.</i>, 2003, <b>125</b>, 5636-5637) with catalyst support engineering. Specifically, using graphene oxide as a catalyst support for iron oxide (Fe<sub>3</sub>O<sub>4</sub>) catalyst nanoparticles, we achieved high density growth of CNTs grown by the "kite-mechanism". Our analysis revealed that the fast-heating method reduced undesired aggregation of the catalyst nanoparticles, which has been reported to be a primary limitation mechanism, by shortening the time between substrate heating and CNT growth. In addition, the use of the graphene oxide support led to controllable and uniform dispersion of catalyst nanoparticles in relatively high density which provided increased process control by extending the time before the onset of catalyst aggregation. Together, these approaches suppressed the aggregation of the catalyst nanoparticles, which facilitated the "tip-growth" mode instead of the "root-growth" mode, and led to the high density growth of ultralong CNTs. Our results also indicate additional limitations and complexities on the high density CNT growth by the kite-growth approach, which limit high density synthesis.
Diamond Nano-electromechanical Systems (2014)

Nano-electromechanical systems (NEMS) are extraordinary in their ability to transduce minute mechanical signals into an electrical response. The methods of inducing and detecting mechanical, electrical, or biological signals using diamond NEMS structures are discussed in this chapter. Diamond, with its unique mechanical, thermal, and chemical properties, is a fascinating material. It often outperforms conventional NEMS materials, such as silicon. Advances in thin-film growth and fabrication methods now make it possible to manufacture ever more sensitive devices with far-reaching implications in both applied and fundamental research. This chapter illustrates the inner workings of diamond NEMS devices. Furthermore, opportunities and technological challenges in the field of diamond NEMS are discussed.
Tensor-Based Adaptive Filtering Algorithms (2021)

Tensor-based signal processing methods are usually employed when dealing with multidimensional data and/or systems with a large parameter space. In this paper, we present a family of tensor-based adaptive filtering algorithms, which are suitable for high-dimension system identification problems. The basic idea is to exploit a decomposition-based approach, such that the global impulse response of the system can be estimated using a combination of shorter adaptive filters. The algorithms are mainly tailored for multiple-input/single-output system identification problems, where the input data and the channels can be grouped in the form of rank-1 tensors. Nevertheless, the approach could be further extended for single-input/single-output system identification scenarios, where the impulse responses (of more general forms) can be modeled as higher-rank tensors. As compared to the conventional adaptive filters, which involve a single (usually long) filter for the estimation of the global impulse response, the tensor-based algorithms achieve faster convergence rate and tracking, while also providing better accuracy of the solution. Simulation results support the theoretical findings and indicate the advantages of the tensor-based algorithms over the conventional ones, in terms of the main performance criteria.
Efficiency and Electron Leakage Characteristics in GaN-Based Light-Emitting Diodes Without AlGaN Electron-Blocking-Layer Structures (2011)

The authors investigate efficiency and electron leakage characteristics in GaN-based light-emitting diodes (LEDs) without AlGaN electron-blocking-layer (EBL) structures. Both simulation and electroluminescence (EL) measurement results show that the internal quantum efficiency decreases rapidly as the thickness of an undoped GaN interlayer between active layers and a p-GaN layer increases, which is caused by electron leakage from active layers to the p-GaN due to inefficient hole injection. However, photoluminescence (PL) measurement results show that the quality of active layers deteriorates as the interlayer thickness decreases. The EL and PL results imply that the optimization of the undoped GaN interlayer thickness is important for achieving high internal quantum efficiency in AlGaN-EBL-free LEDs.
Mechanistic studies of a tyrosine-dependent catalytic antibody (1991)

A pre-steady-state multiple-turnover kinetic burst is observed during hydrolysis of phenyl acetate by the catalytic antibody, 20G9. The burst is caused by partial product inhibition by phenol (Ki,app = 2.5 microM), which lowers both kcat and KM by almost an order of magnitude without affecting kcat/KM. The acid limb of the steady-state kcat pH profile of native 20G9 has a pKa of 9.6, suggesting a catalytic role for tyrosine. Additional evidence for an essential tyrosyl residue is that mild treatment of 20G9 with tetranitromethane nitrates a single tyrosine per equivalent of antigen binding sites and the mononitrated derivative has less than 5% of the native activity. Near-UV absorbance spectroscopy suggests that the alternative substrates N-carbobenzoxyglycine O-phenyl ester (ZG-OPh) and N-acetylglycine O-phenyl ester (AcG-OPh) acylate multiple tyrosines on the antibody. Neither ZG-OPh nor AcG-OPh are measurably catalyzed once appreciable acylation has taken place. Antibody acylated by ZG-OPh is inactive toward phenyl acetate hydrolysis, but can be reactivated by hydroxylamine. The data and derived kinetic rate equations are consistent with an acyl mechanism for phenyl acetate hydrolysis in which phenol inhibits by binding to a covalent O-acetyltyrosyl intermediate, slowing deacylation. Although the data are consistent with such a mechanism, they do not rule out other plausible, yet less unifying mechanisms of phenol inhibition; the observed burst could conceivably result from partial mixed phenol inhibition or from phenol-induced nonproductive substrate binding. Because antibodies often use tyrosines in antigen binding, tyrosyl catalytic antibodies may be commonly encountered in the future.
Safety of an Aujeszky's disease vaccine based on deletion mutant strain 783 which does not express thymidine kinase and glycoprotein I. (1990)

The safety of an Aujeszky's disease virus vaccine based on strain 783, a deletion mutant which does not express glycoprotein I and thymidine kinase, was assessed in pigs, calves and sheep. Four-day-old piglets which were inoculated intranasally and intramuscularly with 10(7) plaque forming units (PFU) developed only slight depression and fever. The virus was transmitted to a sentinel piglet. Six weeks after inoculation, the pigs were injected with high doses of corticosteroids in an attempt to reactivate the vaccine virus. The pigs did not shed Aujeszky's disease virus, did not develop a rise in virus neutralising antibody titres and sentinel pigs remained seronegative to Aujeszky's disease virus. Strain 783 was passaged in two series of three- to five-day old piglets, but after the third and fourth passages virus could no longer be recovered. Pregnant sows were inoculated with 10(7) PFU of virus strain 783 around day 35 or on day 85 of pregnancy, and their fetuses and piglets were assayed for Aujeszky's disease virus and antibodies against Aujeszky's disease virus. No evidence was found for transplacental transmission of the virus. Calves and sheep were given 10(7) PFU of virus strain 783 intranasally or intramuscularly; they survived and did not develop clinical signs of Aujeszky's disease. All the sheep and the calves inoculated intramuscularly developed neutralising antibodies to Aujeszky's disease virus.
ChemInform Abstract: New Organic Nitrates. Part 1. Synthesis of 1,3‐Benzoxazine‐2,4‐dione, 1,3‐Benzoxazine‐2‐thion‐4‐one, 1,3‐Benzothiazine‐2,4‐dione and Quinazoline‐2,4‐dione Derivatives. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Susceptibility comparisons of normal preoperative conjunctival bacteria to fluoroquinolones (2009)

Because many methicillin-resistant and fluoroquinolone-resistant strains were isolated from the conjunctiva preoperatively, clinicians should be mindful of endophthalmitis or ocular infections associated with these strains.