gebhart/patrepeval huggingface dataset:
Pulse compression in a time variant system with application to ultrasonic vibrometry (2013)

Pulse compression is normally applied only to time-invariant systems, as the variation of a system's properties during its interrogation violates assumptions of the compression process. However, there is an exact solution to the pulse-compression problem when the time variance satisfies two criteria, which are the same as those required for the operation of an ultrasonic vibrometer in the context of a tissue elastography system. One is that the variations be very small in comparison with the wavelength of the interrogating ultrasound. The other is that the bandwidth of the variations be within one Nyquist band as sampled by the periodic interrogation signal. The solution to this problem involves a step-wise interpolation of the static pulse-compression transfer function in the frequency domain. This technique, in conjunction with the selection of an appropriate interrogation signal, offers significant advantages in measurement time or measurement resolution for an ultrasonic vibrometer limited by additive noise at the receiver. The characteristics of optimal interrogation signals for this technique are the signal's crest factor, spectral energy distribution, and phasing. These relate to the intended compression pulse, the noise, and the static response of the system. The technique has been demonstrated analytically, experimentally, and with numerical models.
Biomarker associations of immune checkpoint inhibitor versus chemotherapy effectiveness in first-line metastatic endometrial carcinomas: A real-world study. (2022)

5596 Background: Limited evidence exists comparing outcomes of single-agent anti-PD1 immune checkpoint inhibitors (ICPI) vs. chemotherapy in the 1 st line among metastatic endometrial carcinoma (mEC) patients. dMMR, MSI status, and Tumor Mutational Burden (TMB) have been characterized as predictive biomarkers of ICPI response in many solid tumors, including mEC. We sought to evaluate ICPI vs. chemotherapy effectiveness in 1st line mEC, stratified by TMB ≥ 10 mut/MB and MSI as assessed by next-generation sequencing. Methods: Following a prespecified analysis plan, this study used the nationwide (̃280 US cancer clinics) de-identified, EHR-derived, Flatiron Health-Foundation Medicine mEC clinico-genomic database (FH-FMI CGDB), with tissue CGP between 1/2011 - 6/2021. Cohort inclusion criteria: recurrent mEC patients with stage I-III at original diagnosis, 1 st line ICPI or platinum chemotherapy treatment with TMB and MSI assessments available. Adjusted hazard ratios (aHR) from multivariable Cox proportional hazard models were utilized for time to next treatment (TTNT) and overall survival (OS) comparisons between 1L chemotherapy and 1L ICPI from start of 1L treatment stratified by TMB (≥ 10 vs. &lt; 10) and adjusted for ECOG, BMI, and stage at diagnosis. Results: Among the 1 st line cohort, patients received either Chemotherapy (n = 139, 87%) or first-line ICPI (n = 20, 13%). While the overlap between the TMB ≥ 10 (n = 46) population and MSI-H (n = 39) populations was high, with 38/46 (83%) of TMB ≥ 10 classified as MSI-H and 38/39 (97%) of MSI-H with a TMB ≥ 10, there were also 8 (17%) TMB ≥ 10 patients who were MSS. TMB ≥ 10 was associated with more favorable TTNT (aHR: 0.11 [0.03 - 0.44]) and OS (aHR: 0.1 [0.01 - 0.82]) on single-agent ICPIs vs. chemotherapy; however, TMB &lt; 10 patients exhibited no observed differences in TTNT (aHR: 1.66 [0.79 - 3.48]) or OS (aHR: 1.79 [0.66 - 4.8]) between treatments. MSI-H pts were associated with more favorable TTNT (aHR: 0.1 [0.02 - 0.39]) and OS (aHR: 0.1 [0.01 - 0.86]) on single-agent ICPIs over chemotherapy; however, MSS pts did not observe differences in TTNT (aHR: 1.5 [0.65 - 3.5]) or OS (aHR: 2.14 [0.63 - 7.26]) between ICPI vs. chemotherapy. Conclusions: Recurrent 1 st line mEC patients with TMB ≥ 10 and/or MSI-H exhibit more favorable outcomes on single-agent ICPI than standard chemotherapy in real-world settings. These findings warrant prospective randomized validation. Future studies should assess the utility of a combined biomarker approach across TMB and MSI status to identify the broadest group of patients who might benefit from ICPI.
Rigid formations of autonomous agents (2004)

This thesis addresses rigid formations of autonomous agents. A key element in all future multi-agent systems will be the role of sensor and communication networks as an integral part of coordination. Network topologies are critically important for autonomous systems involving mobile underwater, ground and air vehicles and for sensor networks. This thesis focuses on developing techniques and strategies for the analysis and design of sensor and network topologies required to achieve a rigid formation for cooperative tasks. We address using different types of information, such as distances, directions, bearings, and angles between agents, to maintain rigid formations. Energy efficiency and communication bandwidth are critically important in formations of mobile autonomous agents, and hence strategies that make efficient use of power and energy are beneficial. Therefore, we develop topologies for providing sensing and communications with the minimum number of links, and propose methods requiring the minimum number of changes in the set of links in dynamic missions and maneuvers, including agent departure from a rigid formation, splitting a rigid formation and merging rigid sub-formations. To do this in a systematic manner, it is necessary to develop a framework for modeling agent
Novel triarylamine‐based alternating conjugated polymer with high hole mobility: Synthesis, electro‐optical, and electronic properties (2010)

Abstract Novel bi‐triphenylamine‐containing aromatic dibromide M3 , N , N ‐bis(4‐bromophenyl)‐ N ′, N ′‐dipheny‐l,4‐phenylenediamine, was successfully synthesized. The novel conjugated polymer P1 having number‐average molecular weight of 1.31 × 10 4 was prepared via Suzuki coupling from the dibromide M3 and 9,9‐dioctylfluorene‐2,7‐diboronic acid bis(1,3‐propanediol) ester. Polymer P1 had excellent thermal stability associated with a high glass‐transition temperature ( T g = 141 °C). The hole‐transporting and UV‐vis‐near‐infrared electrochromic properties were examined by electrochemical and spectroelectrochemical methods. Cyclic voltammograms of the conjugated polymer films cast onto indium‐tin oxide‐coated glass substrates exhibited two reversible oxidation redox couples at E 1/2 values of 0.73 and 1.13 V versus Ag/Ag + in acetonitrile solution. The hole mobility of the conjugated polymer P1 revealed ∼10 −3 cm 2 V −1 s −1 , which is much higher than that of other conjugated polymer systems. The observed UV‐vis‐near‐infrared absorption change in the conjugated polymer film P1 at applied potentials ranging from 0.00 to 1.23 V are fully reversible and associated with strong color changes from pale yellowish in its neutral form to green and blue in its oxidized form. Using a combination of experimental study and theoretical investigation, we proposed an oxidation mechanism based on molecular orbital theory, which explains the cyclic voltammetry experimental results well. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2010
Down-regulation of human extracellular cysteine protease inhibitors by the secreted staphylococcal cysteine proteases, staphopain A and B (2007)

Of seven human cystatins investigated, none inhibited the cysteine proteases staphopain A and B secreted by the human pathogen Staphylococcus aureus. Rather, the extracellular cystatins C, D and E/M were hydrolyzed by both staphopains. Based on MALDI-TOF time-course experiments, staphopain A cleavage of cystatin C and D should be physiologically relevant and occur upon S. aureus infection. Staphopain A hydrolyzed the Gly11 bond of cystatin C and the Ala10 bond of cystatin D with similar Km values of approximately 33 and 32 microM, respectively. Such N-terminal truncation of cystatin C caused >300-fold lower inhibition of papain, cathepsin B, L and K, whereas the cathepsin H activity was compromised by a factor of ca. 10. Similarly, truncation of cystatin D caused alleviated inhibition of all endogenous target enzymes investigated. The normal activity of the cystatins is thus down-regulated, indicating that the bacterial enzymes can cause disturbance of the host protease-inhibitor balance. To illustrate the in vivo consequences, a mixed cystatin C assay showed release of cathepsin B activity in the presence of staphopain A. Results presented for the specificity of staphopains when interacting with cystatins as natural protein substrates could aid in the development of therapeutic agents directed toward these proteolytic virulence factors.
One-chip Integrated Module of MEMS Shock Sensor and Sensing Amplifier LSI using Pseudo-SOC Technology (2010)

We have been developing the pseudo-SOC technology for one-chip module integration of heterogeneous devices that realizes high electrical performance and high density of devices embodying the advantages of both SOC technology and SIP technology. Especially, this technology is available for MEMS-LSI integration. We developed a 0.2mm-thickness one-chip module integrating a MEMS shock sensor and a sensing amplifier LSI by applying this technology. The MEMS shock sensor and the sensing amplifier LSI were connected by high-rigidity epoxy resin optimized the material constants to reduce the stress and the warpage resulting from resin shrinkage due to curing. Then the planar insulating layer and the redistributed conducting layer were formed on it for the global layer. The MEMS shock sensor was preformed to be modularized with a glass cap. Electrical contacts were achieved by bonding of Au bumps on the MEMS fixed electrodes and via holes filled with Ag paste of the glass cap. Functional performance was confirmed by obtaining signal corresponding to the reference signal of the pick-up sensor. Furthermore, stress analysis was performed using the FEM model simulation considering the resin shrinkage.
Identification by Reverse Vaccinology of Three Virulence Factors in Burkholderia cenocepacia That May Represent Ideal Vaccine Antigens (2023)

The <i>Burkholderia cepacia</i> complex comprises environmental and clinical Gram-negative bacteria that infect particularly debilitated people, such as those with cystic fibrosis. Their high level of antibiotic resistance makes empirical treatments often ineffective, increasing the risk of worst outcomes and the diffusion of multi-drug resistance. However, the discovery of new antibiotics is not trivial, so an alternative can be the use of vaccination. Here, the reverse vaccinology approach has been used to identify antigen candidates, obtaining a short-list of 24 proteins. The localization and different aspects of virulence were investigated for three of them-BCAL1524, BCAM0949, and BCAS0335. The three antigens were localized in the outer membrane vesicles confirming that they are surface exposed. We showed that BCAL1524, a collagen-like protein, promotes bacteria auto-aggregation and plays an important role in virulence, in the <i>Galleria mellonella</i> model. BCAM0949, an extracellular lipase, mediates piperacillin resistance, biofilm formation in Luria Bertani and artificial sputum medium, rhamnolipid production, and swimming motility; its predicted lipolytic activity was also experimentally confirmed. BCAS0335, a trimeric adhesin, promotes minocycline resistance, biofilm organization in LB, and virulence in <i>G. mellonella</i>. Their important role in virulence necessitates further investigations to shed light on the usefulness of these proteins as antigen candidates.
Telomerase enzyme activity and RNA expression during the multistage pathogenesis of breast carcinoma. (1998)

Telomerase, an RNA-containing enzyme, is associated with cellular immortality and malignancy. We investigated the role of telomerase during the multistage pathogenesis of breast cancer. We used the semiquantitative, PCR-based telomeric repeat amplification protocol assay for enzyme activity (42 specimens from 42 patients) and a radioactive in situ assay for expression of its RNA component (human telomerase RNA; hTR) for the identification of telomerase-positive cells in archival resection samples (n = 67 from 39 patients). Low telomerase activity was detected in 1 (14%) of 7 samples of benign breast disease, in 4 (67%) of 6 fibroadenomas, in 11 (92%) of 12 carcinoma in situ (CIS) lesions, and in 16 (94%) of 17 invasive breast cancers. There was a progressive increase in the mean telomerase levels with progressive increase in severity of histopathological change (P < 0.05). Almost all of 67 resection samples expressed hTR, irrespective of histology. Expression was low to moderate in some samples of normal epithelium and nonproliferative fibrocystic changes. hTR expression was limited to epithelial cells; expression in stromal cells, including those in fibroadenomas, was negative. Increased hTR expression was observed in some foci of apocrine metaplasia and atypical hyperplasia. Increased hTR expression was also observed in all CIS and invasive lesions, although considerable heterogeneity was noted. Focal up-regulation was frequently noted in CIS lesions in the vicinity of invasive tumors. Thus, up-regulation of hTR may be a predictive marker for invasive tumor development.
Dok-6, a Novel p62 Dok Family Member, Promotes Ret-mediated Neurite Outgrowth (2004)

Activation of Ret, the receptor-tyrosine kinase for the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs), results in the recruitment and assembly of adaptor protein complexes that function to transduce signals downstream of the receptor. Here we identify Dok-6, a novel member of the Dok-4/5 subclass of the p62 Dok family of intracellular adaptor molecules, and characterize its interaction with Ret. Expression analysis reveals that Dok-6 is highly expressed in the developing central nervous system and is co-expressed with Ret in several locations, including sympathetic, sensory, and parasympathetic ganglia, as well as in the ureteric buds of the developing kidneys. Pull-down assays using the Dok-6 phosphotyrosine binding (PTB) domain and GDNF-activated Ret indicate that Dok-6 binds to the phosphorylated Ret Tyr(1062) residue. Moreover, ligand activation of Ret resulted in phosphorylation of tyrosine residue(s) located within the unique C terminus of Dok-6 predominantly through a Src-dependent mechanism, indicating that Dok-6 is a substrate of the Ret-Src signaling pathway. Interestingly, expression of Dok-6 potentiated GDNF-induced neurite outgrowth in GDNF family receptor alpha1 (GFRalpha1)-expressing Neuro2A cells that was dependent upon the C-terminal residues of Dok-6. Taken together, these data identify Dok-6 as a novel Dok-4/5-related adaptor molecule that may function in vivo to transduce signals that regulate Ret-mediated processes such as axonal projection.
Associations of Subclinical Cardiovascular Disease With Frailty (2001)

Cardiovascular disease was associated with an increased likelihood of frail health. In those with no history of CVD, the extent of underlying cardiovascular disease measured by carotid ultrasound and ankle-arm index, LV hypertrophy by ECG and echocardiography, was related to frailty. Infarct-like lesions in the brain on magnet resonance imaging were related to frailty as well.
CuCo2O4ORR/OER Bi-Functional Catalyst: Influence of Synthetic Approach on Performance (2015)

A series of CuCo<sub>2</sub>O<sub>4</sub> catalysts were synthesized by pore forming, sol-gel, spray pyrolysis and sacrificial support methods. Catalysts were characterized by XRD, SEM, XPS and BET techniques. The electrochemical activity for the oxygen reduction and oxygen evolution reactions (ORR and OER) was evaluated in alkaline media by RRDE. Density Functional Theory was used to identify two different types of active sites responsible for ORR/OER activity of CuCo<sub>2</sub>O<sub>4</sub> and it was found that CuCo<sub>2</sub>O<sub>4 </sub>can activate the O-O bond by binding molecular oxygen in bridging positions between Co or Co and Cu atoms. It was found that the sacrificial support method (SSM) catalyst has the highest performance in both ORR and OER and has the highest content of phase-pure CuCo<sub>2</sub>O<sub>4</sub>. It was shown that the presence of CuO significantly decreases the activity in oxygen reduction and oxygen evolution reactions. As a result, the half-wave potential (E<sub>1/2</sub>) of CuCo<sub>2</sub>O<sub>4</sub>-SSM was found as 0.8 V, making this material a state-of-the-art, unsupported oxide catalyst.
Molecular mechanisms on embryonic stem cell pluripotency (2007)

Derived from early embryo, embryonic stem (ES) cells have potential to self renew indefinitely and develop to any type of cells in human body (pluripotency). Several extrinsic signals such as LIF, BMPs and Wnt can support the self-renewal and pluripotency of embryonic stem (ES) cells through regulating the pluri- potent genes. In combination with intrinsic transcription factors such as FoxD3, Nanog, Oct4 , these factors form a regulatory network to support or limit each other's expression level, which maintain the properties of ES cells.
The Covalent Binding of Alkaline Phosphatase on Porous Supports and the Stability of the Immobilized Enzyme (1988)

Abstract : Alkaline phosphatase was covalently bound to a series of porous silicas and controlled-pore glasses using different silanization procedures and derivatization methods in order to determine the conditions that would lead to the highest immobilized enzyme (IME) activity and stability. Aqueous silanization was found to give more controlled surface coverage of the porous support than toluene silanization; aqueous silanization also resulted in more stable IMEs. Nearly identical IME activities were obtained with aqueous silanization and three different derivatization methods. The IME formed with diisothiocyanate derivatization had the greatest stability in cold, dry storage but the poorest stability in cold, alkaline buffer. IMEs formed with glutaraldehyde were consistently more stable than those IMEs formed with carbodiimide derivatization. Keywords: Thin films; Films; Immobilized enzymes.
Blind polarization demultiplexing algorithm for multi-level modulation formats in stokes vector direct detection systems (2017)

In the Stokes vector direct detection (SV-DD) system, we extend a previously-proposed simple blind polarization demultiplexing (POL-DEMUX) algorithm for PSK constellations to QAM constellations. We numerically analyze the POL-DEMUX performance and confirm that the blind POL-DEMUX process can be successfully done with negligible power penalties for high-order modulation formats such as 8-PSK, 16-PSK and 16-QAM even under conditions with fast SOP fluctuation.
ChemInform Abstract: New Syntheses of Diaza‐Crown Ethers Using BOC Protecting Groups. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Event Detection Based on Noisy Object Information (2013)

This paper proposes an event detection method using noisy object information. Some events have a close connection with objects, and the objects related to the event often appear with the event in a video. For example, if an event "Grooming an animal" appears in a video, an animal and people should appear in the video. If we detect the objects that have a close connection with the events, we can detect the events based on the object detection results. However, it is inevitable that the object detector gives false alarms and the object information would be noisy. Thus, we use the information about objects which is robust against false alarms of object detection. In our experiments, we evaluated how the information on objects is effective for event detection of videos. From the results, the proposed method showed better or equivalent detection results than a state-of-theart method in some events, even the object detector gave false alarms.
Progress on the Development of 10 kV 4H-SiC Pin Diodes for High Current/High Voltage Power Handling Applications (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Enhancing the Efficiency of Solution-Processed Polymer:Colloidal Nanocrystal Hybrid Photovoltaic Cells Using Ethanedithiol Treatment (2013)

Advances in colloidal inorganic nanocrystal synthesis and processing have led to the demonstration of organic-inorganic hybrid photovoltaic (PV) cells using low-cost solution processes from blends of conjugated polymer and colloidal nanocrystals. However, the performance of such hybrid PV cells has been limited due to the lack of control at the complex interfaces between the organic and inorganic hybrid active materials. Here we show that the efficiency of hybrid PV devices can be significantly enhanced by engineering the polymer-nanocrystal interface with proper chemical treatment. Using two different conjugated polymers, poly(3-hexylthiophene) (P3HT) and poly[2,6-(4,4-bis(2-ethylhexyl)-4H-cyclopenta[2,1-b;3,4-b']-dithiophene)-alt-4,7-(2,1,3-benzothiadiazole)] (PCPDTBT), we show that treating the polymer:nanocrystal hybrid film in an ethanedithiol-containing acetonitrile solution can increase the efficiency of the hybrid PV devices by 30-90%, and a maximum power conversion efficiency of 5.2 ± 0.3% was obtained in the PCPDTBT:CdSe devices at 0.2 sun (AM 1.5G), which was slightly reduced to 4.7 ± 0.3% at 1 sun. The ethanedithiol treatment did not result in significant changes in the morphology and UV-vis optical absorption of the hybrid thin films; however, infrared absorption, NMR, and X-ray photoelectron spectroscopies revealed the effective removal of organic ligands, especially the charged phosphonic acid ligands, from the CdSe nanorod surface after the treatment, accompanied by the possible monolayer passivation of nanorod surfaces with Cd-thiolates. We attribute the hybrid PV cell efficiency increase upon the ethanedithiol treatment to the reduction in charge and exciton recombination sites on the nanocrystal surface and the simultaneous increase in electron transport through the hybrid film.
Monitoring of Respiration by Means of an Additively Manufactured Barium Titanate-based Hygroscopic Sensor (2019)

Unobtrusive respiration monitoring is critical for a number of applications such as monitoring of sleep apnea and changes in respiration rate. Wearable, flexible sensors provide increased comfort and versatility over traditional rigid sensors. Recent advances in additive manufacturing, such as printed electronics, allow miniaturization of sensors and implementation onto flexible, unobtrusive substrates. In this paper we present implementation and validation of a printed co-doped barium titanate capacitive sensor that is highly sensitive to water vapor as an unobtrusive breathing sensor. This attribute allows the sensor to identify inhalation/exhalation cycles, detect apnea conditions and hyperventilation, and report respiration rate. The 2x4mm sensor demonstrated capacitance changes of up to 1000% during breathing, while placed directly under the nostrils. In addition, we demonstrate that the sensor increases capacitance from 175pF in ambient conditions up to 225pF (almost 30%) during breathing at a distance of 30cm while sampled at 200Hz. We demonstrated viability of this printed sensor for both wearable monitoring and ambient sensing applications.