gebhart/patrepeval huggingface dataset:
Experimental Demonstration of the Corbella Equation for Aperture Synthesis Microwave Radiometry (2007)

The fundamental equation of aperture synthesis microwave radiometry has been recently revised into a new so-called Corbella equation to include antenna coupling effects and the interferometry formulation into a single equation. This equation has been experimentally demonstrated for the first time with a full prototype of the Microwave Imaging Radiometer with Aperture Synthesis. Several tests have been carried out to demonstrate the new visibility equation with different targets. The test results show better agreement with simulations based on the Corbella equation than the old fundamental equation. An initial analysis of the influence of the antenna pattern characterization errors shows the importance of these errors in the final results according to the new formulation
Search for squarks and gluinos in final states with same-sign leptons and jets using 139 fb−1 of data collected with the ATLAS detector (2020)

A bstract A search for supersymmetric partners of gluons and quarks is presented, involving signatures with jets and either two isolated leptons (electrons or muons) with the same electric charge, or at least three isolated leptons. A data sample of proton-proton collisions at $$ \sqrt{s} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> </mml:math> = 13 TeV recorded with the ATLAS detector at the Large Hadron Collider between 2015 and 2018, corresponding to a total integrated luminosity of 139 fb − 1 , is used for the search. No significant excess over the Standard Model expectation is observed. The results are interpreted in simplified supersymmetric models featuring both R -parity conservation and R -parity violation, raising the exclusion limits beyond those of previous ATLAS searches to 1600 GeV for gluino masses and 750 GeV for bottom and top squark masses in these scenarios.
Dark current analysis in high-speed germanium p-i-n waveguide photodetectors (2016)

We present a dark current analysis in waveguide-coupled germanium vertical p-i-n photodetectors. In the analysis, a surface leakage current and a bulk leakage current were separated, and their activation energies were extracted. The surface leakage current originating from the minority carrier generation on the Ge layer sidewalls, governed by the Shockley-Read-Hall process and enhanced by the trap-assisted-tunneling process, was identified as the main contribution to the dark current of vertical p-i-n photodiodes at room temperature. The behavior of this surface leakage current as a function of temperature and reverse bias voltage is well reproduced by using the Hurckx model for trap-assisted-tunneling.
Controlled design of oligomeric ethers with pendant cyclopentadienyliron moieties (1995)

Synthetic strategies for the design of oligomeric ethers with pendant cyclopentadienyliron moieties have been developed. A wide range of these materials have been prepared via nucleophilic aromatic substitution reactions of a mono- or di-hydroxyaromatic nucleophiles and a variety of chloroarene complexes under mild experimental conditions. The mono- and bis-(cyclopentadienyliron) arene complexes were used as building blocks for the larger systems. The crystal structures of three bis(cyclopentadienyliron) arene dications, [(η5-C5H5)Fe(η6-C6H5)-o-XC6H4X-(η6-C6H5)Fe(η5-C5H5)]2+(X = O or S) and [(η5-C5H5)Fe(η6-C6H5)-m-OC6H4O-(η6-C6H5)Fe(η5-C5H5)]2+, have been determined by X-ray crystal structure analysis. A number of routes to the synthesis of the oligomeric species (tri-, tetra- and hexa-iron moieties) have been investigated to determine the flexibility and efficiency of the proposed strategies, and these materials have been fully characterized using spectroscopic and analytical techniques. To prove further the structures of these complexes, some of them have been prepared using different starting materials, giving the same proposed products. A series of polyiron complexes containing terminal hydroxy groups have also been prepared and used as dinucleophiles. The systematic increase in the number of rings and iron moieties allowed full characterization by monitoring the changes in the NMR spectra. Furthermore, the possibility of preparing homo- and mixed-polyaromatic ethers where the number of cyclopentadienyliron moieties varied from two to thirty-five has been demonstrated.
ProteoVision: web server for advanced visualization of ribosomal proteins (2021)

ProteoVision is a web server designed to explore protein structure and evolution through simultaneous visualization of multiple sequence alignments, topology diagrams and 3D structures. Starting with a multiple sequence alignment, ProteoVision computes conservation scores and a variety of physicochemical properties and simultaneously maps and visualizes alignments and other data on multiple levels of representation. The web server calculates and displays frequencies of amino acids. ProteoVision is optimized for ribosomal proteins but is applicable to analysis of any protein. ProteoVision handles internally generated and user uploaded alignments and connects them with a selected structure, found in the PDB or uploaded by the user. It can generate de novo topology diagrams from three-dimensional structures. All displayed data is interactive and can be saved in various formats as publication quality images or external datasets or PyMol Scripts. ProteoVision enables detailed study of protein fragments defined by Evolutionary Classification of protein Domains (ECOD) classification. ProteoVision is available at http://proteovision.chemistry.gatech.edu/.
Comparison of wheelchair securement systems designed for use in large accessible transit vehicles (LATVs) (2019)

Design challenges in wheelchair securement for fixed-route, large accessible transit vehicles (LATVs) often create difficulties for passengers who use wheelchairs and operational inefficiencies for public transit agencies. Recent innovations in wheelchair securement technology for LATVs may reduce these challenges. This study explored the usability of three commercially available wheelchair securement systems in a static laboratory environment: a four-point, forward-facing (4P-FF) securement system, a three-point, forward-facing (3P-FF) securement system, and a semi-automated, rear-facing (SA-RF) securement system. Three groups of mobility device users (manual wheelchair users, power wheelchair users, and scooter users) (<i>n</i> = 36) completed wheelchair securement tasks in a full-scale mock-up of an LATV. For the 19 participants who did not use the occupant restraint system (ORS), perceived usability and securement time were compared across the securement systems. Using multiple usability rating scales, most participants reported that each of the systems would be acceptable for regular use. However, the majority indicated an overall preference for the SA-RF, and most rated the SA-RF system as easier, faster, and requiring less assistance to use than the 4P-FF and 3P-FF systems. Alternatives to conventional 4P-FF wheelchair securement in LATVs may thus improve boarding efficiency and transit independence of passengers who use wheelchairs.
Multifunctional reactive inks, methods of use and manufacture thereof (2023)

In one embodiment, a material includes a plurality of particles, a solvent system and one or more stabilizing agents; the particles are configured to complete a self-propagating and/or self-sustaining reaction upon initiation thereof. In another embodiment, a method includes dispersing a plurality of particles in solution to form a dispersion and adding a stabilizing agent to the dispersion in an amount sufficient to cause the dispersion to exhibit one or more predetermined rheological properties; again, the particles in the dispersion are configured to complete a self-propagating and/or self-sustaining reaction upon initiation thereof. In still another embodiment, a method includes depositing a material on a substrate; the material includes a plurality of particles configured to complete a self-propagating and/or self-sustaining reaction upon initiation thereof, a solvent system and one or more stabilizing agents.
Aortitis – An Interdisciplinary Challenge (2021)

The term 'aortitis' comprises a heterogeneous spectrum of diseases, with varied etiology and clinical presentations, whose common characteristic is the inflammation of the aortic wall. Since aortitis can mimic almost all common cardiovascular disorders, its clinical recognition remains a challenge. Some cases of aortitis remain undetected for a long time and may be diagnosed after severe life-threatening complications have already arisen. The diagnosis of aortitis is based on the presence of homogeneous circumferential thickening of the aortic wall detected on aortic imaging, or typical histological features in combination with clinical findings and laboratory parameters. Management of aortitis is usually conservative (immunosuppressive drugs in noninfectious aortitis; antimicrobial drugs in infectious). However, if vascular complications such as aortic aneurysm, rupture, or steno-occlusive events appear, aortic surgery or endovascular therapy may be required. This review article summarizes the current knowledge regarding the etiology, clinical presentation, diagnosis, and treatment of inflammatory diseases of the aorta to promote better clinical management of these entities.
Pedestrian classification in automotive radar systems (2012)

Urban traffic is dangerous for all car drivers and especially for pedestrians. There are about 5000 fatalities on German streets every year, which is absolutely too much. Human beings have strong limitations in the ability to measure precisely the distance and the speed difference between cars, which is the reason for several accidents. Therefore, the European Union has called all car manufactureres to intensify their research activities in protecting vulnerable road users. An automotive radar sensor measures the target range and radial velocity very accurately and with high resolution even in multiple target situations and there is tremendous progress in 24 GHz radar sensor development. The objective of this paper is to protect vulnerable road users by a target recognition scheme in any urban scenario. One main objective is the difference between lateral moving vehicles and pedestrians in terms of feature extraction and classification. Therefore, a pedestrian detection procedure is additionally integrated into the 24 GHz automotive radar sensor.
Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells (2019)

Extracorporeal photochemotherapy (ECP) is a widely used cancer immunotherapy for cutaneous T cell lymphoma (CTCL), operative in over 350 university centers worldwide. While ECP’s clinical efficacy and exemplary safety profile have driven its widespread use, elucidation of the underlying mechanisms has remained a challenge, partly owing to lack of a laboratory ECP model. To overcome this obstacle and create a simple, user-friendly platform for ECP research, we developed a scaled-down version of the clinical ECP leukocyte-processing device, suitable for work with both mouse models, and small human blood samples. This device is termed the Transimmunization (TI) chamber, or plate. In a series of landmark experiments, the miniaturized device was used to produce a cellular vaccine that regularly initiated therapeutic anti-cancer immunity in several syngeneic mouse tumor models. By removing individual factors from the experimental system and ascertaining their contribution to the in vivo anti-tumor response, we then elucidated key mechanistic drivers of ECP immunizing potential. Collectively, our results revealed that anti-tumor effects of ECP are initiated by dendritic cells (DC), physiologically generated through blood monocyte interaction with platelets in the TI plate, and loaded with antigens from tumor cells whose apoptotic cell death is finely titrated by exposure to the photoactivatable DNA cross-linking agent 8-methoxypsoralen and UVA light (8-MOPA). When returned to the mouse, this cellular vaccine leads to specific and transferable anti-tumor T cell immunity. We verified that the TI chamber is also suitable for human blood processing, producing human DCs fully comparable in activation state and profile to those derived from the clinical ECP chamber. The protocols presented here are intended for ECP studies in mouse and man, controlled generation of apoptotic tumor cells with 8-MOPA, and rapid production of physiologic human and mouse monocyte-derived DCs for a variety of applications.
Realization of Wafer‐Scale 1T‐MoS2 Film for Efficient Hydrogen Evolution Reaction (2021)

The octahedral structure of 2D molybdenum disulfide (1T-MoS<sub>2</sub> ) has attracted attention as a high-efficiency and low-cost electrocatalyst for hydrogen production. However, the large-scale synthesis of 1T-MoS<sub>2</sub> films has not been realized because of higher formation energy compared to that of the trigonal prismatic phase (2H)-MoS<sub>2</sub> . In this study, a uniform wafer-scale synthesis of the metastable 1T-MoS<sub>2</sub> film is performed by sulfidation of the Mo metal layer using a plasma-enhanced chemical vapor deposition (PE-CVD) system. Thus, plasma-containing highly reactive ions and radicals of the sulfurization precursor enable the synthesis of 1T-MoS<sub>2</sub> at 150 °C. Electrochemical analysis of 1T-MoS<sub>2</sub> shows enhanced catalytic activity for the hydrogen evolution reaction (HER) compared to that of previously reported MoS<sub>2</sub> electrocatalysts 1T-MoS<sub>2</sub> does not transform into stable 2H-MoS<sub>2</sub> even after 1000 cycles of HER. The proposed low-temperature synthesis approach may offer a promising solution for the facile production of various metastable-phase 2D materials.
Prediction of Gas Transport Through Ground and Atmosphere to Determine the Ability of Airborne Leak Detection Methods to Detect Pin-Hole Leaks From Buried Gas Pipelines (2008)

New technologies for airborne detection of gas pipeline leaks have been introduced to the pipeline industry and have undergone several field-testing attempts. These technologies are based on an airborne detection device mounted on a small aircraft flying along the right of way (ROW) of the pipeline. It is proposed that during initial commissioning of the pipeline, leak testing is performed by first pressurizing the pipeline section with natural gas, and then launching an airborne leak detection aircraft to fly along the ROW in multiple passes. A delay between the completion of the pipe section pressurization and the launching of the leak detection aircraft is required in order to establish a discernable concentration of methane in the atmosphere. This ‘wait time’ includes the time required for the leak to penetrate upwards through the backfill to the ground surface and to subsequently diffuse into the atmosphere. Accuracy and reliability of these technologies clearly depend on the leak rate (i.e. leak hole size and line pressure), the depth and properties of the backfill, atmospheric conditions, prevailing wind speed and direction, and the properties of air including diffusion parameters of natural gas into air. Additionally, the accuracy of these airborne methods also depends on the altitude at which the aircraft is flying along the pipeline ROW and the degree of offset of the flight path from the centerline of the ROW. The present paper outlines the fundamental governing equations and solution techniques to predict the temporal-spatial-dependent diffusion of gas leakage from a pinhole into the ground. The mechanism of the gas transport through the ground, whether it is advective or diffusive, is dependent on the Pe´clet number, which is predominantly driven by the leak rate. Likewise, the fundamental governing equations along with solution techniques to predict the diffusion of the breakthrough flux of gas at the ground level into the atmosphere are formulated. Results of the time for the gas to break through at ground level, the concentration and gas flux at ground level, and the vertical and lateral concentration profiles of the gas in the atmosphere are all presented to facilitate assessment of the sensitivity of the airborne leak detection methods to the different ground and atmospheric parameters for a given leak rate at a given source depth.
Improving nanoparticle diffusion through tumor collagen matrix by photo-thermal gold nanorods (2016)

Collagen (I) impairs the targeting of nanoparticles to tumor cells by obstructing their diffusion inside dense tumor interstitial matrix. This potentially makes large nanoparticles (>50 nm) reside near the tumor vessels and thereby compromises their functionality. Here we propose a strategy to locally improve nanoparticle transport inside collagen (I) component of the tumor tissue. We first used heat generating gold nanorods to alter collagen (I) matrix by local temperature elevation. We then explored this impact on the transport of 50 nm and 120 nm inorganic nanoparticles inside collagen (I). We demonstrated an increase in average diffusivity of 50 nm and 120 nm in the denatured collagen (I) by ∼14 and ∼21 fold, respectively, compared to intact untreated collagen (I) matrix. This study shows how nanoparticle-mediated hyperthermia inside tumor tissue can improve the transport of large nanoparticles through collagen (I) matrix. The ability to increase nanoparticles diffusion inside tumor stroma allows their targeting or other functionalities to take effect, thereby significantly improving cancer therapeutic or diagnostic outcome.
Trapping of branched DNA in microfabricated structures. (1995)

We have observed electrostatic trapping of tribranched DNA molecules undergoing electrophoresis in a microfabricated pseudo-two-dimensional array of posts. Trapping occurs in a unique transport regimen in which the electrophoretic mobility is extremely sensitive to polymer topology. The arrest of branched polymers is explained by considering their center-of-mass motion; in certain conformations, owing to the constraints imposed by the obstacles a molecule cannot advance without the center of mass first moving a short distance backwards. The depth of the resulting local potential well can be much greater than the thermal energy so that escape of an immobilized molecule can be extremely slow. We summarize the expected behavior of the mobility as a function of field strength and topology and point out that the microfabricated arrays are highly suitable for detecting an extremely small number of branched molecules in a very large population of linear molecules.
Parameter estimation for in vivo magnetic resonance spectroscopy (mrs) using simulated annealing (1990)

A method for estimating the spectral parameters from a noisy FID is proposed. The method uses a priori information concerning the lower and upper limits between which such parameters' values can exist. Computer simulation results show that, using the proposed method, values of the spectral parameters can be accurately estimated from a noisy FID.
Effect of Lanreotide Depot/Autogel on Urinary 5-Hydroxyindoleacetic Acid and Plasma Chromogranin A Biomarkers in Nonfunctional Metastatic Enteropancreatic Neuroendocrine Tumors (2018)

Current guidelines focus only on the monitoring of 5-hydroxyindoleacetic acid (5-HIAA) in the diagnosis and management of functional neuroendocrine tumors with carcinoid syndrome. The current post hoc analysis of patients with nonfunctional enteropancreatic neuroendocrine tumors in the CLARINET study demonstrated that measuring and following both 5-HIAA and chromogranin A as biomarkers of disease progression may be useful in the management of patients with nonfunctional neuroendocrine tumors.
Data from Src Inhibition with Saracatinib Reverses Fulvestrant Resistance in ER-Positive Ovarian Cancer Models <i>In Vitro</i> and <i>In Vivo</i> (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; More effective, less toxic treatments for recurrent ovarian cancer are needed. Although more than 60% of ovarian cancers express the estrogen receptor (ER), ER-targeted drugs have been disappointing due to drug resistance. In other estrogen-sensitive cancers, estrogen activates Src to phosphorylate p27 promoting its degradation and increasing cell-cycle progression. Because Src is activated in most ovarian cancers, we investigated whether combined Src and ER blockade by saracatinib and fulvestrant would circumvent antiestrogen resistance.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; ER and Src were assayed in 338 primary ovarian cancers. Dual ER and Src blockade effects on cell cycle, ER target gene expression, and survival were assayed in ERα+ ovarian cancer lines, a primary human ovarian cancer culture &lt;i&gt;in vitro&lt;/i&gt;, and on xenograft growth.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Most primary ovarian cancers express ER. Src activity was greater in ovarian cancer lines than normal epithelial lines. Estrogen activated Src, ER-Src binding, and ER translocation from cytoplasm to nucleus. Estrogen-mediated mitogenesis was via ERα, not ERβ. While each alone had little effect, combined saracatinib and fulvestrant increased p27 and inhibited cyclin E-Cdk2 and cell-cycle progression. Saracatinib also impaired induction of ER-target genes &lt;i&gt;c-Myc&lt;/i&gt; and &lt;i&gt;FOSL1&lt;/i&gt;; this was greatest with dual therapy. Combined therapy induced autophagy and more effectively inhibited ovarian cancer xenograft growth than monotherapy.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Saracatinib augments effects of fulvestrant by opposing estrogen-mediated Src activation and target gene expression, increasing cell-cycle arrest, and impairing survival, all of which would oppose antiestrogen resistance in these ER+ ovarian cancer models. These data support further preclinical and clinical evaluation of combined fulvestrant and saracatinib in ovarian cancer. &lt;i&gt;Clin Cancer Res; 18(21); 5911–23. ©2012 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Steroids Inhibit Eosinophil Accumulation and Downregulate Hematopoietic Chemotaxic Prostaglandin D2 Receptor in Aspirin-Exacerbated Respiratory Disease (2020)

This study provides clear evidence that systemic steroid therapy inhibits eosinophil activation and decreases HPGDS and DP2 expression in patients with AERD, indicating a reduction in prostaglandin D<sub>2</sub> production and hence control hyperplasia of nasal polyps.
Rebamipide prevented delay of wound repair induced by hydrogen peroxide and suppressed apoptosis of gastric epithelial cells in vitro. (1998)

The effects of rebamipide on the restoration process of gastric epithelial wounds were assessed using an in vitro wound-healing model and hydrogen peroxide treatment. Rebamipide (10 or 100 microM) was added to a complete monolayer cell sheet after artificial wounding. The restoration process was analyzed sequentially by a time-lapse video system, and cell migration, proliferation, and apoptosis were assessed. Hydrogen peroxide (1 or 3 mM) inhibited restoration after wounding by suppressing cell migration and proliferation. It also induced epithelial cell apoptosis around the wound. The addition of rebamipide abolished the H2O2-induced retardation and prevented apoptosis. Rebamipide might act as a radical scavenger and have favorable effects on peptic ulcer diseases.