gebhart/patrepeval huggingface dataset:
ESD characterisation of a-IGZO TFTs on Si and foil substrates (2017)

Amorphous Indium-Gallium-Zinc-Oxide (a-IGZO) Thin-Film Transistors (TFTs) integrated with Si based CMOS processes is an emerging technology in ultra-low power applications. ESD characteristics of a-IGZO TFTs with a Si substrate are studied and compared to their characteristics on traditional foil/glass substrate. The ESD performance is shown to be improved, thanks to improved thermal properties of the different buffer material. The layout dependency of ESD behaviors in Si substrate TFTs are investigated in order to meet the 1kV HBM ESD requirement. An on-chip ESD protection design with a gate-coupling TFT is proposed.
Glucocorticoid Inhibition of RANTES Expression in Human Lung Epithelial Cells (1995)

An influx of eosinophils into the lungs occurs in several pulmonary disorders. However, the mechanisms involved remain unknown. Lung epithelial cell release of eosinophil chemotactic factors such as RANTES or macrophage inflammatory protein-1 alpha (MIP-1 alpha) could account for the influx of eosinophils into the lungs. In order to demonstrate the potential role for lung epithelial cells to release RANTES and/or MIP-1 alpha, we investigated the mRNA expression and protein release in cultured A549 cells. Tumor necrosis factor-alpha (TNF alpha) and interleukin-1 beta (IL-1 beta) induced a time- and dose-dependent increase in RANTES mRNA expression and protein release. In contrast, MIP-alpha protein release was not detectable in these cells. As corticosteroids decrease the influx of eosinophils into the lungs in vivo, we also investigated the capacity of dexamethasone to decrease the TNF alpha-induced RANTES release and mRNA expression; both were decreased in a time- and concentration-dependent manner. Dexamethasone did not affect the TNF alpha-induced RANTES mRNA half-life and did not require protein synthesis to manifest an inhibitory effect. Supernatant from cells stimulated with TNF alpha and IL-1 beta increased eosinophil chemotaxis and this was also inhibited by dexamethasone. These findings suggest a role for RANTES release by lung epithelial cells in the recruitment of eosinophils into the lungs in pulmonary disorders such as interstitial lung diseases, idiopathic pulmonary fibrosis, or asthma and suggest that one beneficial effect of corticosteroids may be inhibition of lung epithelial cell RANTES mRNA expression and protein release.
Modulation of insulin degrading enzyme activity: A link between T2DM and liver cancer? (2015)

Diabetes mellitus Type 2, insulin therapy and hyperinsulinemia are risk factors of liver cancer in recently published prospective studies. Insulin degrading enzyme (IDE) is a major enzyme responsible for insulin degradation in the liver. Recently, the use of a novel IDE inhibitor was proposed as a new therapeutic strategy to treat type 2 diabetes. Here we hypothesized that IDE inhibition might stimulate liver cell proliferation via increased intracellular insulin concentration and characterized effects of IDE knockdown on the transcriptome and proliferation rate of HepG2 hepatoma cells. We found that IDE knockdown dysregulated expression of genes involved in the cell cycle and apoptosis. In details, the expression of p53-dependent pro-apoptotic genes, FAS and CCNG2, was decreased, whereas the expression of TP53I3 and SESN1 increased in IDE knockdown cells compared to controls. Furthermore, proliferation markers MKI67, MCM2 and PCNA were significantly up-regulated. Nevertheless, the proliferation rate was lower in IDE knockdown cells compared to controls. We conclude that the using of IDE inhibitors for diabetic treatment should be carefully tested regarding its potential effect on hepatic tumorogenesis in animal studies
Non-core based shared tree architecture for IPmulticasting (1999)

The core-based tree (CBT) has three main limitations. The selection of the core node is difficult and the traffic is concentrated near the core router. Also the CBT does not consider an optimisation of network resource utilisation. In the proposed non-core based tree (NCBT), an on-tree node is assigned to each incoming member for multicasting such that the maximum end-to-end delay and the tree costs are jointly minimised.
Degrees-of-Freedom Region of Time Correlated MISO Broadcast Channel with Perfect Delayed CSIT and Asymmetric Partial Current CSIT (2012)

The impact of imperfect CSIT on the degrees of freedom (DoF) of a time correlated MISO Broadcast Channel has drawn a lot of attention recently. Maddah-Ali and Tse have shown that the completely stale CSIT still benefit the DoF. In very recent works, Yang et al. have extended the results by integrating the partial current CSIT for a two-user MISO broadcast channel. However, those researches so far focused on a symmetric case. In this contribution, we investigate a more general case where the transmitter has knowledge of current CSI of both users with unequal qualities. The essential ingredient in our work lies in the way to multicast the overheard interference to boost the DoF. The optimal DoF region is simply proved and its achievability is shown using a novel transmission scheme assuming an infinite number of channel uses.
Polymer Field Effect Transistors of F8T2 Prepared by Evaporative Spray Deposition using Ultradilute Solution Technique (2008)

The evaporative spray deposition using ultradilute solution (ESDUS) technique enables layer-by-layer and pixel-by-pixel deposition of polymer semiconductors. In this study we prepared thin films of dioctylfluorene-co-bithiophene) alternating copolymer, F8T2, by ESDUS and by a conventional spin-coat. These films were made into fabricated field effect transistors to investigate carrier transportation properties. Since the organic films were formed by deposition of aerosol particles in ESDUS, the carrier transportation properties in ESDUS films had been expected lower than those in spin-coat films, which are formed through spread polymer solution. However, the device performance was almost identical, indicating that the polymer deposited as particles undergoes rearrangement process on the substrate.
Antagonistic Effect of Androgen on Prostatic Cell Death (1985)

No AccessJournal of Urology1 Mar 1985Antagonistic Effect of Androgen on Prostatic Cell Death J.T. Isaacs J.T. IsaacsJ.T. Isaacs More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)49083-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Antagonistic Effect of Androgen on Prostatic Cell Death." The Journal of Urology, 133(3), p. 553 © 1985 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 133Issue 3March 1985Page: 553 Advertisement Copyright & Permissions© 1985 by The American Urological Association Education and Research, Inc.MetricsAuthor Information J.T. Isaacs More articles by this author Expand All Advertisement PDF downloadLoading ...
Multiple-microphone time-varying filters for robust speech recognition (2004)

A multiple microphone time varying filter that is an extension of the dual-microphone speech enhancement technique of P. Aarabi et al. (see Proceedings of the IEEE Conference on Multimedia and Expo, Baltimore, Maryland, July 2003) is proposed and experimentally analyzed. The technique utilizes information regarding the locations of the speech source of interest and the microphones to compute a time varying filter that results in substantial noise reduction over other speech enhancement techniques such as delay-and-sum beamforming and superdirective beamforming. For example, digit recognition results in an environment with two speakers and a reverberation time of 0.1s show a recognition accuracy rate increase of 25.2% over delay-and-sum beamforming and an increase of 26.5% over superdirective beamforming using six microphones.
Anti‐Compression and Anti‐Angiogenic Therapy for Breast Cancer (2015)

Anti-angiogenic therapy has been a potential therapeutic strategy for various types of cancer because deregulated angiogenesis contributes to tumor progression. However, current anti-angiogenic therapy has problems such as rebound tumor growth and resistance to the therapy. Recently, we have shown that physical compaction - the process in which cells gather and pack together- induces brain tumor progression by changing the expression of a major angiogenic factor, vascular endothelial growth factor (VEGF). Here we show that physical compaction of E771 mammary tumor tissues also compresses blood vessels and the inhibition of collagen crosslinking using lysyl oxidase (LOX) inhibitor, which disrupts collagen structure and suppresses tumor cell compaction, decreases expression of VEGFR2, suppresses tumor angiogenesis, and breast cancer growth in mice. Knockdown of Wnt co-receptor low-density lipoprotein receptor-related protein (LRP5) suppresses VEGFR2 expression in endothelial cells in vitro and tumor angiogenesis and breast cancer progression are inhibited in Lrp5 knockout mice in an orthotopic mouse E771 breast cancer model in vivo. Importantly, inhibition of LRP5 and LOX has synergistic inhibitory effects on breast cancer progression. These findings suggest that tumor micromechanical environment and chemical LRP5 signaling exhibit crosstalk and inhibit breast cancer growth more efficiently through a VEGF-VEGFR2 signaling. This project is supported by Boston Children's Hospital Career Development Award and Department of Defense.
Supplementary Figure 6 from Global Evaluation of Eph Receptors and Ephrins in Lung Adenocarcinomas Identifies EphA4 as an Inhibitor of Cell Migration and Invasion (2023)

&lt;p&gt;PDF file, 726K, EPHA4 and morphology.&lt;/p&gt;
Translocation of Inducible Tyrosine Aminotransferase to the Mitochondrial Fraction (1974)

Abstract Acute uremia induced both soluble and mitochondrial tyrosine aminotransferase activity, EC 2.6.1.5, in rat liver. Such induction was demonstrated to be independent of glucocorticoid action. Mitochondrial aspartate aminotransferase, EC 2.6.1.1, although identical with mitochondrial tyrosine aminotransferase, was not elevated during acute uremia. Purified antibody specific against cytosol tyrosine aminotransferase cross-reacted significantly with the mitochondrial enzyme from uremic rats, suggesting that the elevation of activity was due to translocation of the induced cytosol enzyme form to the mitochondria. Considerable translocation was also caused by a combination of fasting together with some factor known to increase urea synthesis in the liver, such as high nitrogen loads or intraperitoneal injection of hydrocortisone. Intravenous injection of rats with Triton WR-1339 resulted in the separation of lysosomes from mitochondria during sucrose density gradient centrifugation. All of the tyrosine aminotransferase activity was associated with the mitochondria and not with the lysosomes. Treatment of intact mitochondria with the antisoluble tyrosine aminotransferase antibody resulted in inhibition of about 50% of the total inhibitable mitochondrial activity, suggesting that some of the translocated cytosol enzyme may not be exposed and thus may be unavailable for antibody cross-reaction. In vitro crossover experiments using induced cytosol tyrosine aminotransferase with normal mitochondria resulted in an elevation of the mitochondrial activity, whereas incubation of noninduced cytosol enzyme with mitochondria from induced rats did not. Consequently, the translocation phenomenon is a function of altered cytosol tyrosine aminotransferase rather than altered mitochondria.
1024 x 1024 Si: as IBC detector arrays for MID-IR astronomy (2006)

1K x 1K Si:As Impurity Band Conduction (IBC) arrays have been developed by Raytheon Vision Systems for the James Webb Space Telescope (JWST) Mid-Infrared Instrument (MIRI). These devices are also suitable for other low-background applications. The Si:As IBC detectors have a pixel dimension of 25 &#956;m and respond to infrared radiation between 5 and 28 &#956;m. Detector performance results are discussed, including response and dark current as a function of detector bias and relative spectral response. The features of the matching 1024 x 1024 Readout Integrated Circuit (ROIC) features are discussed. Noise data from the University of Rochester are shown with the ROIC operating at 7 K. Sensor Chip Assembly (SCA) data are presented showing noise, response uniformity, and dark current. Design details of a companion 1024 x 1024 array suitable for high-background, ground-based astronomy will also be revealed for the first time. This array will have a large well capacity and be capable of high frame rates.
Supplementary figures 1-8 from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs (2023)

&lt;p&gt;Supplementary Figure S1. Additional analysis of siRNA effects on ciliation and target depleton. Supplementary Figure S2. Sorafenib is similar to sunitinib in inducing ciliary resorption. Supplementary Figure S3. Effect of compounds on AURKA catalytic activity. Supplementary Figure S4. Representative images demonstrating the effect of sunitinib (A) and ganetespib (B) on cilia resorption in hTERT-RPE1-Arl13b-GFP cells. Supplementary Figure S5. Cilia length upon treatment with indicated cilia-stabilizing compounds in hTERT-RPE1 (A) and NIH3T3 (B) cell lines. Supplementary Figure S6. Drug effects on ciliation correspond to changes in cell cycle over time. Supplementary Figure S7. Erlotinib increases ciliation in CFPAC-1 but not in PNX0010 cell line. Supplementary Figure S8. Representative Western blot images and quantitation of PDGF-AA-induced activation of PDGFR and MEK1/2 in NIH3T3 cells, related to Figures 3F, G.&lt;/p&gt;
Author Correction: Enhancing catalytic performance of dilute metal alloy nanomaterials (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
A Miniaturized Face Shear Mode Quartz Crystal Resonator (1992)

This paper describes a miniaturized face shear mode quartz crystal resonator of 4.2 to 6.0 MHz. An object of this paper is to clarify theoretically and experimentally frequency characteristics, frequency temperature behavior and electrical characteristics for the resonator. Another object is to provide a miniaturized resonator with high shock-resistance. The analysis results are then compared with the measured data. As a result, the frequency constant derived from the theoretical analysis agrees well with the measured values and the resonators with high shock-resistance are also found to have a sufficiently small series resistance R 1 , a high quality factor and a zero temperature coefficient, even if it was extremely miniaturized.
Chemical Kinomics (2004)

This chapter contains sections titled: Introduction Chemical Biology: The Hope Chemical Kinomics: A Target Gene Family Approach in Chemical Biology Protein Kinase Inhibitor History Chemical Kinomics: An Amenable Approach Examples of Traditional Chemical Genomics Using Kinase Inhibitors Forward Chemical Genomics Using a Kinase-biased Compound Library Chemical Validation Orthogonal Chemical Genetics ASKAs: Analog-sensitive Kinase Alleles Cohen's Inhibitor-insensitive p38 Mutants Active Inhibitor-insensitive Kinase Mutants (Orthogonal Protein Kinases) Chemical Proteomics for Kinases: KinaTorTM Conclusions
Abstract 5394: Dual inhibition of the androgen receptor by ligand blockade and antisense-mediated downregulation is associated with synergistic antitumor activity model of prostate cancer (2011)

Abstract Background: Although new agents to treat prostate cancer have recently been approved, and new investigational drugs (Abiraterone and MDV3100) that mediate hormone deprivation show promising data from late-stage clinical trials, these therapies typically extend overall survival up to 4 months in patients with advanced disease who have failed conventional androgen deprivation therapy. Hence, there continues to be great medical need. EZN-4176 is a novel LNA-based antisense oligonucleotide (EZN-4176) that down regulates androgen receptor (AR) expression. Previously, antitumor activity of EZN-4176 in multiple xenograft models including both androgen-sensitive and castrate-resistant tumors was shown. More importantly, a synergistic effect was also found when EZN-4176 was combined with MDV3100. Further exploration of the mechanistic underpinning of the effect was explored here. Methods: The mRNA, growth, luciferase activity, protein, and prostate specific antigen (PSA) were evaluated by qRT-PCR, MTT, SteadyGlo, western blot analysis, and ELISA assay, respectively. The effect of EZN-4176 on AR transcriptional activity was evaluated in cells stably express luciferase gene regulated by AR. In vivo, the effect of EZN-4176 on AR transcriptional activity was evaluated in a bone tumor model developed by intratibia injection of C4-2b-AR-luc cells. Results: Combination of EZN-4176 with MDV3100 resulted in a much improved inhibitory effect in colony formation assay in vitro. This effect was not associated with enhanced efficiency of AR mRNA down-modulation as treatment with EZN-4176 with or without MDV3100 showed similar effects on the level of AR mRNA. However, when AR transcriptional activity was examined, we found that the combined effect was greater than each agent alone. In C4-2b-AR-luc bone tumor model, EZN-4176 potently and specifically down-modulated AR-luciferase reporter activity. Further examinations of the anti-tumor effect in this model will help understand the potential of the combinatorial effect in a highly relevant disease model. Conclusions: Our preliminary data suggest that the synergistic anti-tumor effect of EZN-4176 in combination with MDV3100 is in part associated with much reduced transcriptional activity of AR. EZN-4176 alone or in combination with anti-androgens offers great potential in treating patients with advanced prostate cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5394. doi:10.1158/1538-7445.AM2011-5394
Up-regulation of Foxo4 mediated by hepatitis B virus X protein confers resistance to oxidative stress-induced cell death (2011)

The hepatitis B virus X (HBX) protein, a regulatory protein of the hepatitis B virus (HBV), has been shown to generate reactive oxygen species (ROS) in human liver cell lines; however, the mechanism by which cells protect themselves under this oxidative stress is poorly understood. Here, we show that HBX induces the up-regulation of Forkhead box class O 4 (Foxo4) not only in Chang cells stably expressing HBX (Chang-HBX) but also in primary hepatic tissues from HBX-transgenic mice. HBX also increased ROS, but reduction of the abundance of ROS using N-acetylcystein (NAC) diminished the levels of Foxo4. Elevated Foxo4 was also detected in nuclei of Chang-HBX cells but not in Chang cells stably expressing the vector (Chang-Vec), suggesting that HBX activates the transcriptional activity of Foxo4. When we examined whether HBX bypasses JNK signaling that targets Foxo4, we found that the activity of JNK but not of ERK is required for the up-regulation of Foxo4 even in the presence of HBX. Furthermore, the reduction of Foxo4 levels using siRNA or a JNK inhibitor rendered Chang-HBX cells sensitive to apoptosis under oxidative stress, suggesting that up-regulation of Foxo4 mediated by HBX enhances resistances to oxidative stress-induced cell death. Accordingly, we propose that Foxo4 may be a useful target for suppression in the treatment of HBV-associated hepatocellular carcinoma cells.
Erratum: Vibrational relaxation in jet-cooled alkyl benzenes [J. Chem. Phys. 7 1, 3886 (1979)] (1980)

First Page
Temporal patterns of pudendal afferent stimulation modulate reflex bladder activation (2013)

Electrical stimulation of pudendal nerve (PN) afferents to cause reflex activation or inhibition of the bladder is a promising approach to restore control of bladder function in persons with dysfunction caused by disease or injury. The objective of this work was to evaluate the effects of novel temporal patterns of stimulation on the size of isovolumetric stimulation-evoked reflex bladder contractions and determine if the temporal pattern, of stimulation, like frequency, modulates the reflex bladder response to stimulation. The temporal pattern of stimulation significantly affected the size of bladder contractions evoked by stimulation in anesthetized cats. Patterns with pauses and random patterns evoked significantly smaller bladder contractions, while patterns with subtle changes in inter-pulse-intervals (IPIs), ramp trains and alternating IPI trains, occasionally evoked larger bladder contractions than constant frequency stimulation. The use of new temporal patterns of electrical stimulation should be considered in the development of neural prosthetics for the restoration of lower urinary tract function.
Light-mediated curing of CO2-based unsaturated polyethercarbonates via thiol–ene click chemistry (2016)

Facile cross-linking of CO<sub>2</sub>-based unsaturated polyethercarbonates with polymercaptanes <italic>via</italic> thiol–ene click chemistry makes them highly interesting sustainable pre-polymers for material applications.
Structural Modeling and Site-Directed Mutagenesis of the Actinorhodin β-Ketoacyl-Acyl Carrier Protein Synthase (2000)

A three-dimensional model of the Streptomyces coelicolor actinorhodin beta-ketoacyl synthase (Act KS) was constructed based on the X-ray crystal structure of the related Escherichia coli fatty acid synthase condensing enzyme beta-ketoacyl synthase II, revealing a similar catalytic active site organization in these two enzymes. The model was assessed by site-directed mutagenesis of five conserved amino acid residues in Act KS that are in close proximity to the Cys169 active site. Three substitutions completely abrogated polyketide biosynthesis, while two replacements resulted in significant reduction in polyketide production. (3)H-cerulenin labeling of the various Act KS mutant proteins demonstrated that none of the amino acid replacements affected the formation of the active site nucleophile.
Ankylosis of traumatized permanent incisors: pathogenesis and current approaches to diagnosis and management. (2005)

Ankylosis is a known complication of replanted or severely intruded permanent incisors and can be diagnosed by the characteristic sound emitted when the tooth is tapped. The ankylosed incisor demonstrates a lack of physiologic mobility and, later, radiographic evidence of replacement resorption. If the patient is pre-adolescent or adolescent at the time of trauma, infraocclusion relative to adjacent teeth will become apparent during jaw growth. Despite considerable knowledge about the pathogenesis of ankylosis garnered from animal studies and observation of human replanted teeth, there is no known treatment to arrest this condition. Management techniques and rehabilitation options for addressing ankylosis and its consequences are supported by little evidence, do not appear to be widely adopted and do not offer any proven long-term benefit. Avulsion and severe intrusion of permanent incisors are rare injuries. Should the decision be made to intervene by replantation or reduction of the intrusion, the clinician must be prepared to diagnose ankylosis, identify its negative consequences and develop treatment plans accordingly.