gebhart/patrepeval huggingface dataset:
Hypothermia-treated cardiac arrest patients with good neurological outcome differ early in quantitative variables of EEG suppression and epileptiform activity* (2009)

Objective: To evaluate electroencephalogram-derived quantitative variables after out-of-hospital cardiac arrest. Design: Prospective study. Setting: University hospital intensive care unit. Patients: Thirty comatose adult patients resuscitated from a witnessed out-of-hospital ventricular fibrillation cardiac arrest and treated with induced hypothermia (33°C) for 24 hrs. Interventions: None. Measurements and Main Results: Electroencephalography was registered from the arrival at the intensive care unit until the patient was extubated or transferred to the ward, or 5 days had elapsed from cardiac arrest. Burst-suppression ratio, response entropy, state entropy, and wavelet subband entropy were derived. Serum neuron-specific enolase and protein 100B were measured. The Pulsatility Index of Transcranial Doppler Ultrasonography was used to estimate cerebral blood flow velocity. The Glasgow-Pittsburgh Cerebral Performance Categories was used to assess the neurologic outcome during 6 mos after cardiac arrest. Twenty patients had Cerebral Performance Categories of 1 to 2, one patient had a Cerebral Performance Categories of 3, and nine patients had died (Cerebral Performance Categories of 5). Burst-suppression ratio, response entropy, and state entropy already differed between good (Cerebral Performance Categories 1–2) and poor (Cerebral Performance Categories 3–5) outcome groups (p = .011, p = .011, p = .008) during the first 24 hrs after cardiac arrest. Wavelet subband entropy was higher in the good outcome group between 24 and 48 hrs after cardiac arrest (p = .050). All patients with status epilepticus died, and their wavelet subband entropy values were lower (p = .022). Protein 100B was lower in the good outcome group on arrival at ICU (p = .010). After hypothermia treatment, neuron-specific enolase and protein 100B values were lower (p = .002 for both) in the good outcome group. The Pulsatility Index was also lower in the good outcome group (p = .004). Conclusions: Quantitative electroencephalographic variables may be used to differentiate patients with good neurologic outcomes from those with poor outcomes after out-of-hospital cardiac arrest. The predictive values need to be determined in a larger, separate group of patients.
Optimized Maximum Power Point Tracker for Fast-Changing Environmental Conditions (2008)

This paper presents a high-performance maximum power point tracker (MPPT) optimized for fast cloudy conditions, e.g., rapidly changing irradiation on the photovoltaic panels. The rapidly changing conditions are tracked by an optimized hill-climbing MPPT method called dP-P&O. This algorithm separates the effects of the irradiation change from the effect of the tracker's perturbation and uses this information to optimize the tracking according to the irradiation change. The knowledge of the direction of the irradiation change enables the MPPT to use different optimized tracking schemes for the different cases of increasing, decreasing, or steady irradiance. When the irradiance is changing rapidly this strategy leads to faster and better tracking, while in steady-state conditions it leads to lower oscillations around the MPP. The simulations and experimental results show that the proposed dP-P&O MPPT provides a quick and accurate tracking even in very fast changing environmental conditions.
A New Strategy for Cyclopentenone Synthesis (2000)

[reaction--see text] A new strategy for the synthesis of 2,3-disubstituted cyclopentenones emerges from two key reactions-the ruthenium-catalyzed three-component coupling of an equivalent of HBr, an alkyne, and a vinyl ketone and the Ni-Cr Barbier type reaction. As a result, these important structures are readily accessed from an alkyne and a vinyl ketone (which derive directly from carboxylic acids). Syntheses of tetrahydrodicranenone B and rosaprostol illustrate the new strategy.
On the MAC for Power-Line Communications: Modeling Assumptions and Performance Tradeoffs (2014)

Power-line communications are becoming a key component in home networking. The dominant MAC protocol for high data-rate power-line communications, IEEE 1901, employs a CSMA/CA mechanism similar to the back off process of 802.11. Existing performance evaluation studies of this protocol assume that the back off processes of the stations are independent (the so-called decoupling assumption). However, in contrast to 802.11, 1901 stations can change their state after sensing the medium busy, which introduces strong coupling between the stations and, as a result, makes existing analyses inaccurate. In this paper, we propose a new performance model for 1901, which does not rely on the decoupling assumption. We prove that our model admits a unique solution. We confirm the accuracy of our model using both test bed experiments and simulations, and we show that it surpasses current models based on the decoupling assumption. Furthermore, we study the trade off between delay and throughput existing with 1901. We show that this protocol can be configured to accommodate different throughput and jitter requirements, and we give systematic guidelines for its configuration.
Role of the S' Subsites in Serine Protease Catalysis. Active-Site Mapping of Rat Chymotrypsin, Rat Trypsin, .alpha.-Lytic Protease, and Cercarial Protease from Schistosoma mansoni (1994)

The S' subsite specificity of four homologous serine proteases, rat chymotrypsin, rat trypsin, alpha-lytic protease, and cercarial protease from Schistosoma mansoni, was studied by measuring acyl-transfer reactions to 100 pentapeptide nucleophiles. Peptides of the general structures H-Xaa-Ala-Ala-Ala-Ala-NH2, H-Ala-Xaa-Ala-Ala-Ala-NH2, and H-Ala-Ala-Xaa-Ala-Ala-NH2 were synthesized, where Xaa is D-Ala, Cit, and all natural amino acids except Cys. The variable residues of these nucleophiles occupy the P'1, P'2, and P'3 positions in acyl-transfer reactions. The P'1 and P'2 residues were found to influence the efficiency of the nucleophiles by more than 2 orders of magnitude, whereas the S'3 subsite shows a lower specificity in all four enzymes. We synthesized consensus peptides of the general structure H-aa1-aa2-aa3-Ala-Ala-NH2, in which two or three positions were occupied by amino acids that showed the highest specificity in the first series of nucleophiles. Peptides with optimal amino acid residues in the P'2 and P'3 positions show a very high efficiency in chymotrypsin- and trypsin-catalyzed reactions. Otherwise, large specific side chains in the P'1 and P'3 positions of the nucleophiles show less than additive binding contributions due to steric hindrance. Comparison of chymotrypsin-catalyzed acyl-transfer reactions to nucleophiles of the structures H-Xaa-Leu-Arg-Ala-Ala-NH2 and H-Xaa-Ala-Ala-Ala-Ala-NH2 reveals a significantly different P'1 specificity for both series which confirms steric hindrance between large P'1 and P'3 residues.(ABSTRACT TRUNCATED AT 250 WORDS)
Light Propagation in Field-Ionizing Media: Extreme Nonlinear Optics (1999)

A novel equation for light propagation in underdense field-ionizing media is derived by extending concepts of nonlinear optics into the strong-field domain. The equation is first order in the propagation coordinate and is valid for arbitrarily short pulse durations. Solutions of the first-order wave equation are found to be in excellent agreement with solutions of the scalar wave equation. Furthermore, the polarization response of a field-ionizing medium is derived from semiclassical considerations. The polarization reveals, in agreement with experiments, a previously unrecognized contribution that is shown to significantly affect the absorption loss in the presence of ionization.
Glutamate weighted imaging contrast in gliomas with 7 Tesla magnetic resonance imaging (2019)

This study supports the role of glutamate in diffuse glioma biology. It further implicates elevated peritumoural glutamate in epileptogenesis and altered tumour glutamate homeostasis in glioma aggressiveness. Given the ability to non-invasively visualise and quantify glutamate, our findings raise the prospect of 7 T GluCEST selecting patients for individualised therapies directed at the glutamate pathway. Larger studies with prospective follow-up are required.
Whisker experience‐dependent mGluR signaling maintains synaptic strength in the mouse adolescent cortex (2016)

Sensory experience-dependent plasticity in the somatosensory cortex is a fundamental mechanism of adaptation to the changing environment not only early in the development but also in adolescence and adulthood. Although the mechanisms underlying experience-dependent plasticity during early development have been well documented, the corresponding understanding in the mature cortex is less complete. Here, we investigated the mechanism underlying whisker deprivation-induced synaptic plasticity in the barrel cortex in adolescent mice. Layer 4 (L4) to L2/3 excitatory synapses play a crucial role for whisker experience-dependent plasticity in rodent barrel cortex and whisker deprivation is known to depress synaptic strength at L4-L2/3 synapses in adolescent and adult animals. We found that whisker deprivation for 5 days or longer decreased the presynaptic glutamate release probability at L4-L2/3 synapses in the barrel cortex in adolescent mice. This whisker deprivation-induced depression was restored by daily administration of a positive allosteric modulator of the type 5 metabotropic glutamate receptor (mGluR5). On the other hand, the administration of mGluR5 antagonists reproduced the effect of whisker deprivation in whisker-intact mice. Furthermore, chronic and selective suppression of inositol 1,4,5-trisphosphate (IP3 ) signaling in postsynaptic L2/3 neurons decreased the presynaptic release probability at L4-L2/3 synapses. These findings represent a previously unidentified mechanism of cortical plasticity, namely that whisker experience-dependent mGluR5-IP3 signaling in the postsynaptic neurons maintains presynaptic function in the adolescent barrel cortex.
A rare case of Giant Cell Granuloma of both maxillary sinuses (2018)

The Giant Cell Granuloma is a rare, benign tumor of the bone with expansive and osteolytic growth. Because of its common occurrence in the lower jaw it is generally diagnosed and treated by dentists and oral surgeons.
Further studies on the role of astroglia in brain neurons maturation and morphogenesis. (1987)

Using in vitro cultures of dissociated brain neurons and astrocytes, we have compared the morphologies of mesencephalic and striatal neurons cultured for two days on mesencephalic and striatal astrocytes in the four possible combinations. From these comparisons, it appears that: 1. Neurons grown on co-regionalized (homotopic) astrocytes have more primary neurites and branching points than neurons grown on heterotopic astrocytes. 2. The total neuritic length is only slightly affected by the type of co-culture. 3. The branched arborization which develop faster on homotopic astrocytes present several dendritic features. Following these morphological observations, we have been able to demonstrate: 1. That mesencephalic astrocytes (but not striatal astrocytes) secrete trypsin sensitive factors different from laminin and FGF that increase the number of primary neurites and branching points but have no or little effect on total neuritic length. 2. That mesencephalic astrocytes (but not striatal astrocytes) present at their surface a 190 KD glycoprotein specifically recognized by the fucose-specific lectin UEA.
Finding the PKI needles in the Internet haystack (2010)

Public key cryptography can uniquely enable trust within distributed settings. Employing it usually requires deploying a set of tools and services collectively known as a Public Key Infrastructure (PKI). PKIs have become a central asset for many organizations, due to distributed IT and users. Even though the usage of PKIs in closed and controlled environments is quite common, interoperability and usability problems arise when shifting to a broader, open environment. To make an effective trust judgment about a public key certificate, a PKI user needs more than just knowledge of that certificate: she also needs to be able to locate critical parameters such as the certificate repositories and certificate validation servers relevant to that certificate – and all the others the trust path she builds for it. Surprisingly, locating these resources and services remains a largely unsolved problem in real-world X.509 PKI deployment. This issue impacts especially on the usability of this technology and the interoperability of PKIs in open environments such as the Internet. In this paper, we present the design and prototype of a new and flexible solution for automatic discovery of the services and data repositories made available by a Certificate Service Provider (CSP). This contribution will take real-world PKI one step closer to enhancing usability of digital certificates and interoperability between PKIs.
Mobile Ad Hoc networking and the IETF (2000)

article Free Access Share on Mobile Ad Hoc networking and the IETF Authors: Joseph P. Macker Naval Research Lab. Washington, DC Naval Research Lab. Washington, DCView Profile , M. Scott Corson Univ. of Maryland, College Park, MA Univ. of Maryland, College Park, MAView Profile Authors Info & Claims ACM SIGMOBILE Mobile Computing and Communications ReviewVolume 4Issue 1Jan. 2000 pp 13–16https://doi.org/10.1145/360449.360456Online:01 January 2000Publication History 0citation338DownloadsMetricsTotal Citations0Total Downloads338Last 12 Months4Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
The interleukin-17 pathway is involved in human alcoholic liver disease # † (2008)

Abstract Immune dysregulations in alcoholic liver diseases are still unclear, especially regarding alcoholic hepatitis inflammatory burst. Interleukin-17 (IL-17) is known to enhance neutrophil recruitment. We studied the IL-17 pathway in alcoholic cirrhosis and alcoholic hepatitis. Patients with alcoholic liver disease were compared with patients with chronic hepatitis C virus (HCV) infection or autoimmune liver disease and with healthy controls. IL-17 plasma levels and peripheral blood mononuclear cell secretion were assessed by enzyme-linked immunosorbent assay (ELISA) and T cell phenotype by flow cytometry. IL-17 staining and co-staining with CD3 and myeloperoxidase were performed on liver biopsy specimens. IL-17 receptor expression was studied on liver biopsies and in human hepatic stellate cells as well as their response to recombinant IL-17 by chemotaxis assays. IL-17 plasma levels were dramatically increased in alcoholic liver disease patients. Peripheral blood mononuclear cells of patients with alcoholic liver disease produced higher amounts of IL-17, and their CD4 + T lymphocytes disclosed an IL-17–secreting phenotype. In the liver, IL-17–secreting cells contributed to inflammatory infiltrates in alcoholic cirrhosis, and alcoholic hepatitis foci disclosed many IL-17 + cells, including T lymphocytes and neutrophils. In alcoholic liver disease, liver IL-17 + cells infiltrates correlated to model for end-stage liver disease score, and in alcoholic hepatitis to modified discriminant function. IL-17 receptor was expressed in alcoholic liver disease by hepatic stellate cells, and these cells recruited neutrophils after IL-17 stimulation in a dose-dependent manner through IL-8 and growth related oncogen α (GRO-α) secretion in vitro . Conclusion: Human alcoholic liver disease is characterized by the activation of the IL-17 pathway. In alcoholic hepatitis, liver infiltration with IL-17–secreting cell infiltrates is a key feature that might contribute to liver neutrophil recruitment. (Clinical trials number NCT00610597). (Hepatology 2009;49:646–657.)
Serological classification of Neisseria gonorrhoeae with monoclonal antibodies (1982)

Hybrid cells producing monoclonal antibodies against antigens of Neisseria gonorrhoeae were obtained by the polyethylene glycol-mediated fusion of mouse myeloma cells and lymphocytes from mice immunized with gonococcal protein I or outer membrane proteins. From four fusions, 16 phenotypically stable, independently cloned hybrid cell lines were selected for continued study. Each of the cell lines produced a characteristically different monoclonal antibody which reacted in immunoprecipitation assays with a unique antigenic determinant on protein I of the outer membrane complex of the bacteria. In antibody binding, immunofluorescence, and coagglutination assays these antibodies each reacted with a restricted group of N. gonorrhoeae strains. None of the monoclonal antibodies reacted with 17 other different species of Neisseria or with Branhamella catarrhalis. When tested on 34 N. gonorrhoeae reference serotyping strains, the monoclonal antibodies demonstrated serological relationships between the strains which paralleled those observed with conventional polyvalent antisera. These antibodies now provide standardized reagents for the rapid and precise serological characterization of many strains of N. gonorrhoeae.
NMD‐deficient Upf3b‐null mice display behavioral and neuropathological defects (2012)

To address the physiological role of nonsense‐mediated RNA decay (NMD), we generated mice with a null mutation in the Upf3b NMD gene. While these Upf3b‐null mice are viable, fertile, and grossly normal, a battery of behavioral tests revealed they exhibit a specific defect in sensorimotor gating. This defect is commonly displayed in Schizophrenia patients, a subset of whom have recently been shown by several groups to have mutations in the human UPF3B gene. Neuropathological examination of the frontal cortex, the site responsible for sensorimotor gating, revealed decreased dendritic spine density and mature dendritic spines in pyramidal cells. Intriguingly, such defects are also observed in schizophrenic and autistic patients. To understand the underlying mechanisms by which UPF3B acts in this circuit, we performed exon‐array analysis of the frontal cortex of Upf3b‐null mice. This revealed dysregulation of several mRNAs transcribed from genes mutated in intellectual disability patients, most of which encode proteins that function in sensory perception and cognition. NMD is likely to have a direct role in regulating many of these transcripts, as most have “NMD‐inducing features.” We propose that Upf3b‐null mice are a useful model system to understand the underlying mechanism of sensorimotor gating and how it is disrupted in Schizophrenia patients. This study was supported by the NIH.
MicroRNAs and Cell Cycle Regulation (2007)

MicroRNAs (microRNAs) are abundant, approximately 21-25 nucleotide (nt) non-coding RNAs that mediate sequence-specific, post-transcriptional repression of mRNA targets. Emerging evidence suggests that several microRNAs target transcripts that encode proteins directly or indirectly involved in cell cycle progression and cellular proliferation. Moreover, alteration of microRNA levels can contribute to pathological conditions, including tumorigenesis, that are associated with loss of cell cycle control. In this review we highlight recent data linking microRNAs to mammalian cell cycle regulation. We describe how specific miRNAs function within pathways that control cell cycle checkpoints. We discuss emerging evidence that support the idea that some microRNA activity may be cell cycle dependent, and we outline how the coordinate regulation of microRNA targets may influence cell cycle progression.
Excited states in the neutron-deficient nucleiRn197,199,201 (2008)

Excited states of the extremely neutron-deficient radon isotopes with $N=111,113,115$ have been studied for the first time in a series of in-beam experiments performed at the Accelerator Laboratory of the University of Jyv\"askyl\"a. The reactions used were: $^{118}\mathrm{Sn}$($^{82}\mathrm{Kr}$, $3n$)$^{197}\mathrm{Rn}$, $^{120}\mathrm{Sn}$($^{82}\mathrm{Kr}$, $3n$)$^{199}\mathrm{Rn}$, $^{150}\mathrm{Sm}$($^{52}\mathrm{Cr}$, $3n$)$^{199}\mathrm{Rn}$, and $^{122}\mathrm{Sn}$($^{82}\mathrm{Kr}$, $3n$)$^{201}\mathrm{Rn}$. The \ensuremath{\gamma} rays emitted from excited states in the different isotopes were identified using the recoil-\ensuremath{\alpha}-decay tagging technique. The estimated cross section for the production of ${}^{197}{\mathrm{Rn}}^{m}$ was 7(3) nb, which is the lowest cross section reported so far for an in-beam study. The energies of the $(17/{2}^{+})$ levels built on the isomeric $(13/{2}^{+})$ states in $^{197,199,201}\mathrm{Rn}$ indicate a transition from an anharmonic vibrational structure toward a rotational structure at low spins for these nuclei. However, the transition is not as sharp as predicted by theory.
Pioneers in Medical Imaging Series (2014)

The <i>Journal of Medical Imaging</i> (JMI) allows for the peer-reviewed communication and archiving of fundamental and translational research, as well as applications, focused on medical imaging, a field that continues to benefit from technological improvements and yield biomedical advancements in the early detection, diagnostics, and therapy of disease as well as in the understanding of normal conditions.
Animating Chinese paintings through stroke-based decomposition (2006)

This article proposes a technique to animate a Chinese style painting given its image. We first extract descriptions of the brush strokes that hypothetically produced it. The key to the extraction process is the use of a brush stroke library, which is obtained by digitizing single brush strokes drawn by an experienced artist. The steps in our extraction technique are first to segment the input image, then to find the best set of brush strokes that fit the regions, and, finally, to refine these strokes to account for local appearance. We model a single brush stroke using its skeleton and contour, and we characterize texture variation within each stroke by sampling perpendicularly along its skeleton. Once these brush descriptions have been obtained, the painting can be animated at the brush stroke level. In this article, we focus on Chinese paintings with relatively sparse strokes. The animation is produced using a graphical application we developed. We present several animations of real paintings using our technique.
Effects of the angiotensin II receptor antagonist, TCV-116, on blood pressure and the renin-angiotensin system in healthy subjects. (1994)

TCV-116 is a new, nonpeptide, angiotensin II type-1 receptor antagonist that acts as a specific inhibitor of the renin-angiotensin system. In this study, 36 healthy male volunteers were administered single and repeated oral doses of TCV-116 to investigate its effects on blood pressure and heart rate, and to evaluate the safety and pharmacokinetics of the drug. At single doses of 2.5 mg and greater, TCV-116 significantly lowered blood pressure even in normotensive subjects. This hypotensive effect was maintained during repeated administration on a once-daily regimen over an 8-day period. Serum concentration of M-1, an active metabolite of TCV-116, increased in a dose-dependent manner, reaching a peak 3 to 4 hours after administration. An amount of M-1 equivalent to approximately 10% of the administered dose of TCV-116 was excreted in the urine during the first 24 hours following administration. No accumulation of M-1 was observed in subjects receiving repeated administration of TCV-116. No adverse effects were observed except for mild headache in three subjects. These results suggest that the renin-angiotensin system plays a role in the regulation of blood pressure, even in normotensive subjects, and that TCV-116 may prove to be useful in the treatment of hypertension.