gebhart/patrepeval huggingface dataset:
Simultaneous radial, femoral, and aortic arterial pressures during human cardiopulmonary resuscitation (1993)

Radial artery relaxation-phase pressure, although statistically higher, correlated with aortic relaxation-phase pressure. Femoral artery relaxation-phase pressure was not statistically different from aortic relaxation-phase pressure. Aortic pressure was statistically higher and had a lower correlation with radial artery pressures during compression phase. The aortic to radial artery and aortic to femoral artery compression-phase gradients abated with increasing doses of epinephrine therapy. Caution must be used when substituting compression-phase pressure obtained at radial or femoral artery sites for aortic pressure during human CPR. Coronary artery perfusion pressures obtained with radial and femoral arteries correlate with aortic pressure when measuring the response to vasopressor therapy during CPR when an interpretable waveform exists.
Draw tower fiber Bragg gratings and their use in sensing technology (2011)

The idea of fabricating fiber Bragg gratings already during the drawing of a fiber dates back almost 20 years. The application of a transverse holographic writing method on a draw tower offers a promising solution for a highly effective Bragg grating production. Because of the high technology requirements it took more than 10 years to develop the method into a reliable process. During the last five years the improvements in the technical development enables cost effective industrial production of draw tower gratings (<sup>1</sup>DTG<sup>®</sup>). In this paper we report about new possibilities of the improved process with respect to the grating type (type I gratings, type II gratings), the coating type (<sup>2</sup>ORMOCER<sup>®</sup>, metals) and the fiber type and diameter (125&#956;m, 80&#956;m and below). Furthermore, we present examples for the application of draw tower fiber Bragg gratings in sensing technologies for medical applications.
Study of the Null Directions on The Performance of Differential Beamformers (2022)

Null directions are important parameters for differential beamformers, which play an important role on the beamforming performance. In this paper, we investigate the performance of differential beamformers as a function of the null directions. We first derive the directivity factor (DF) as an explicit function of null and show that the DF decreases to 0 if any null approaches to the desired look direction. We then validate the theoretical analysis through simulations using the beampattern, DF and signal-to-interference gain as the performance measures. The results show that: 1) the performance of a differential beamformer degrades significantly if there is any null close to the desired look direction; 2) with a fixed null direction, increasing the order of the differential beamformer can help improve performance.
DUckCov: a Dynamic Undocking‐Based Virtual Screening Protocol for Covalent Binders (2019)

Thanks to recent guidelines, the design of safe and effective covalent drugs has gained significant interest. Other than targeting non-conserved nucleophilic residues, optimizing the noncovalent binding framework is important to improve potency and selectivity of covalent binders toward the desired target. Significant efforts have been made in extending the computational toolkits to include a covalent mechanism of protein targeting, like in the development of covalent docking methods for binding mode prediction. To highlight the value of the noncovalent complex in the covalent binding process, here we describe a new protocol using tethered and constrained docking in combination with Dynamic Undocking (DUck) as a tool to privilege strong protein binders for the identification of novel covalent inhibitors. At the end of the protocol, dedicated covalent docking methods were used to rank and select the virtual hits based on the predicted binding mode. By validating the method on JAK3 and KRas, we demonstrate how this fast iterative protocol can be applied to explore a wide chemical space and identify potent targeted covalent inhibitors.
Focused Ultrasound Modulation of Hepatic Neural Plexus Restores Glucose Homeostasis in Diabetes (2021)

While peripheral glucose sensors are known to relay signals of substrate availability to integrative nuclei in the brain, the importance of these pathways in maintaining energy homeostasis and their contribution to disease remain unknown. Herein, we demonstrate that selective activation of the hepatoportal neural plexus via transient peripheral focused ultrasound (pFUS) induces glucose homeostasis in models of well-established insulin resistant diabetes. pFUS modulates sensory projections to the hindbrain and alters hypothalamic concentrations of neurotransmitters that regulate metabolism, resulting in potentiation of hypothalamic insulin signaling, leptin-independent inhibition of the orexigenic neuropeptide Y system, and therapeutic alteration in autonomic output to peripheral effector organs. Multiomic profiling confirms pFUS-induced modifications of key metabolic functions in liver, pancreas, muscle, adipose, kidney, and intestines. Activation of the hepatic nutrient sensing pathway not only restores nervous system coordination of peripheral metabolism in three different species but does so across these organ systems; several of which are current targets of antidiabetic drug classes. These results demonstrate the potential of hepatic pFUS as a novel/non-pharmacologic therapeutic modality to restore glucose homeostasis in metabolic diseases, including type II diabetes. One Sentence Summary We utilize a non-invasive ultrasound technique to activate a liver-brain sensory pathway and demonstrate its potential to induce durable normalization of glucose homeostasis in models of well-established insulin resistant diabetes.
ChemInform Abstract: A NEW METHOD FOR THE SYNTHESIS OF OPTICALLY PURE PHOSPHINE OXIDES (1985)

Abstract Aus den sekundären Phosphinoxiden (I) entstehen mit dem Chloressigsäureester (II) die terti‐ ären Phosphinoxide (III), die in die Antipoden getrennt werden.
Timing uncertainty for receivers in optical clock distribution for VLSI (1987)

Optical interconnection techniques have been suggested to reduce signal skew in clock distribution for silicon VLSI chips. One optical approach for clock distribution is to holographically map an optical signal from an off-chip source to several photoreceivers within small functional cells on a chip surface. Within each functional cell, the clock is distributed via short surface wires with negligible delays. In such a system, there are two sources of timing uncertainty: a static uncertainty due to fabrication-related variation of transistor parameters between identically drawn receivers on a chip and a timing jitter due to phase noise at each receiver.
Modelling and analysis of early aggregation events of BMHP1-derived self-assembling peptides (2013)

Despite the increasing use and development of peptide-based scaffolds in different fields including that of regenerative medicine, the understanding of the factors governing the self-assembly process and the relationship between sequence and properties have not yet been fully understood. BMHP1-derived self-assembling peptides (SAPs) have been developed and characterized showing that biotinylation at the N-terminal cap corresponds to better performing assembly and scaffold biomechanics. In this study, the effects of biotinylation on the self-assembly dynamics of seven BMHP1-derived SAPs have been investigated by molecular dynamics simulations. We confirmed that these SAPs self-assemble into β-structures and that proline acts as a β-breaker of the assembled aggregates. In biotinylated peptides, the formation of ordered β-structured aggregates is triggered by both the establishment of a dense and dynamic H-bonds network and the formation of a 'hydrophobic wall' available to interact with other peptides. Such conditions result from the peculiar chemical composition of the biotinyl-cap, given by the synergic cooperation of the uracil function of the ureido ring with the high hydrophobic portion consisting of the thiophenyl ring and valeryl chain. The inbuilt propensity of biotinylated peptides towards the formation of ordered small aggregates makes them ideal precursors of higher hierarchically organized self-assembled nanostructures as experimentally observed.
Long-read, whole-genome shotgun sequence data for five model organisms (2014)

Single molecule, real-time (SMRT) sequencing from Pacific Biosciences is increasingly used in many areas of biological research including de novo genome assembly, structural-variant identification, haplotype phasing, mRNA isoform discovery, and base-modification analyses. High-quality, public datasets of SMRT sequences can spur development of analytic tools that can accommodate unique characteristics of SMRT data (long read lengths, lack of GC or amplification bias, and a random error profile leading to high consensus accuracy). In this paper, we describe eight high-coverage SMRT sequence datasets from five organisms (Escherichia coli, Saccharomyces cerevisiae, Neurospora crassa, Arabidopsis thaliana, and Drosophila melanogaster) that have been publicly released to the general scientific community (NCBI Sequence Read Archive ID SRP040522). Data were generated using two sequencing chemistries (P4C2 and P5C3) on the PacBio RS II instrument. The datasets reported here can be used without restriction by the research community to generate whole-genome assemblies, test new algorithms, investigate genome structure and evolution, and identify base modifications in some of the most widely-studied model systems in biological research.
Search for lepton flavour violation in the eμ continuum with the ATLAS detector in $\sqrt{s} = 7~\mbox{TeV}$ pp collisions at the LHC (2012)

This paper presents a search for the <i>t</i>-channel exchange of an <i>R</i>-parity violating scalar top quark ([Formula: see text]) in the <i>e</i><sup>±</sup><i>μ</i><sup>∓</sup> continuum using 2.1 fb<sup>-1</sup> of data collected by the ATLAS detector in [Formula: see text]<i>pp</i> collisions at the Large Hadron Collider. Data are found to be consistent with the expectation from the Standard Model backgrounds. Limits on <i>R</i>-parity-violating couplings at 95 % C.L. are calculated as a function of the scalar top mass ([Formula: see text]). The upper limits on the production cross section for <i>pp</i>→<i>eμX</i>, through the <i>t</i>-channel exchange of a scalar top quark, ranges from 170 fb for [Formula: see text] to 30 fb for [Formula: see text].
Performance of laser-pumped quantum counters (1965)

Narrow-band quantum counters with less than unit internal quantum efficiency are analyzed. The pump power dependent expressions for the transient and steady-state quantum efficiencies are derived. These quanties are discussed for "typical" trivalent and divalent rare-earth-doped insulator crystals, and the performance of two specific systems is presented. It is shown that to achieve high quantum efficiency in trivalent rare-earth-doped quantum counter systems, the pump source must be highly nonblackbody in spectral character, i.e., a laser, and resonant with the transition between the relevant excited states. Performance limiting factors for laser-pumped quantum counters are pointed out.
Time Reversal of Water Waves (2012)

We present time reversal experiments demonstrating refocusing of gravity-capillary waves in a water tank cavity. Owing to the reverberating effect of the cavity, only a few channels are sufficient to reconstruct the surface wave at the point source, even if the absorption is not negligible. Space-time-resolved measurements of the waves during the refocusing allow us to quantitatively demonstrate that the quality of the refocusing increases linearly with the number of reemitting channels. Numerical simulations corresponding to water waves at larger scales, with negligible damping, indicate the possibility of very high quality refocusing.
Intracellular Ice Formation during the Freezing of Hepatocytes Cultured in a Double Collagen Gel (1991)

During freezing, intracellular ice formation (IIF) has been correlated with loss in viability for a wide variety of biological systems. Hence, determination of IIF characteristics is essential in the development of an efficient methodology for cryopreservation. In this study, IIF characteristics of hepatocytes cultured in a collagen matrix were determined using cryomicroscopy. Four factors influenced the IIF behavior of the hepatocytes in the matrix: cooling rate, final cooling temperature, concentration of Me2SO, and time in culture prior to freezing. The maximum cumulative fraction of cells with IIF increased with increasing cooling rate. For cultured cells frozen in Dulbecco's modified Eagle's medium (DMEM), the cooling rate for which 50% of the cells formed ice (B50) was 70 degrees C/min for cells frozen after 1 day in culture and decreased to 15 degrees C/min for cells frozen after 7 days in culture. When cells were frozen in a 0.5 M Me2SO + DMEM solution, the value of B50 decreased from 70 to 50 degrees C/min for cells in culture for 1 day and from 15 to 10 degrees C/min for cells in culture for 7 days. The value of the average temperature for IIF (TIIF) for cultured cells was only slightly depressed by the addition of Me2SO when compared to the IIF behavior of other cell types. The results of this study indicate that the presence of the collagen matrix alters significantly the IIF characteristics of hepatocytes. Thus freezing studies using hepatocytes in suspension are not useful in predicting the freezing behavior of hepatocytes cultured in a collagen matrix. Furthermore, the weak effect of Me2SO on IIF characteristics implies that lower concentrations of Me2SO (0.5 M) may be just as effective in preserving viability. Finally, the value of B50 measured in this study indicates that cooling rates nearly an order of magnitude faster than those previously investigated could be used for cryopreservation of the hepatocytes in a collagen gel.
Bacterial DNA Sample Preparation from Whole Blood Using Surface-Modified Si Pillar Arrays (2008)

A novel bacterial DNA sample preparation device for molecular diagnostics has been developed. On the basis of optimized conditions for bacterial adhesion, surface-modified silicon pillar arrays for bacterial cell capture were fabricated, and their ability to capture bacterial cells was demonstrated. The capture efficiency for bacterial cells such as Escherichia coli, Staphylococcus epidermidis, and Streptococcus mutans in buffer solution was over 75% with a flow rate of 400 microL/min. Moreover, the proposed method captured E. coli cells present in 50% whole blood effectively. The captured cells from whole blood were then in- situ lyzed on the surface of the microchip, and the eluted DNA was successfully amplified by qPCR. These results demonstrate that the full process of pathogen capture to DNA isolation from whole blood could be automated in a single microchip.
Evaluation of Optically Stimulated Luminescence Properties of Tm-doped NaMgF3 Single Crystal (2020)

Undoped and Tm-doped NaMgF 3 single crystals were synthesized and investigated in terms of their scintillation and optically stimulated luminescence (OSL) properties. The synthesized samples were confirmed by X-ray diffraction to be a single-phase NaMgF 3 . The Tm-doped sample showed an X-ray-induced scintillation spectrum characterized by sharp emission lines owing to the 4f-4f transitions of Tm 3+ . The OSL spectrum of the Tm-doped sample also showed emission at around 360 nm, which was ascribed to the 4f-4f transitions of Tm 3+ . The OSL dose response function of the Tm-doped sample showed a linear response in the dose range of 1-10000 mGy.
On-Line Thermal Barrier Coating Monitoring for Real-Time Failure Protection and Life Maximization (2004)

Under the sponsorship of the U. S. Department of Energy's National Energy Laboratory, Siemens Westinghouse Power Corporation proposes a four year program titled, ''On-Line Thermal Barrier Coating (TBC) Monitor for Real-Time Failure Protection and Life Maximization'', to develop, build and install the first generation of an on-line TBC monitoring system for use on land -based advanced gas turbines (AGT). Federal deregulation in electric power generation has accelerated power plant owner's demand for improved reliability availability maintainability (RAM) of the land-based advanced gas turbines. As a result, firing temperatures have been increased substantially in the advanced turbine engines, and the TBCs have been developed for maximum protection and life of all critical engine components operating at these higher temperatures. Losing TBC protection can therefore accelerate the degradation of substrate components materials and eventually lead to a premature failure of critical component and costly unscheduled power outages. This program seeks to substantially improve the operating life of high cost gas turbine components using TBC; thereby, lowering the cost of maintenance leading to lower cost of electricity. Siemens Westinghouse Power Corporation has teamed with Indigo Systems; a supplier of state-of-the-art infrared camera systems, and Wayne State University, a leading research organization.
Multi-octave, CEP-stable source for high-energy field synthesis (2020)

The development of high-energy, high-power, multi-octave light transients is currently the subject of intense research driven by emerging applications in attosecond spectroscopy and coherent control. We report on a phase-stable, multi-octave source based on a Yb:YAG amplifier for light transient generation. We demonstrate the amplification of a two-octave spectrum to 25 μJ of energy in two broadband amplification channels and their temporal compression to 6 and 18 fs at 1 and 2 μm, respectively. In this scheme, due to the intrinsic temporal synchronization between the pump and seed pulses, the temporal jitter is restricted to long-term drift. We show that the intrinsic stability of the synthesizer allows subcycle detection of an electric field at 0.15 PHz. The complex electric field of the 0.15-PHz pulses and their free induction decay after interaction with water molecules are resolved by electro-optic sampling over 2 ps. The scheme is scalable in peak and average power.
Sample Preparation Issues in NMR‐based Plant Metabolomics: Optimisation for Vitis Wood Samples (2014)

Close attention should be paid to all required procedures before NMR analysis, especially to the selection of an extraction solvent and a deuterated solvent system to perform an extensive metabolomic survey of the specific matrix.
Mouse antibodies to the insulin receptor developing spontaneously as anti-idiotypes. I. Characterization of the antibodies. (1984)

Mice immunized to ungulate insulins were found to develop antibodies of two specificities: insulin antibodies that were mostly IgG1 and IgG2 antibodies that acted both as anti-idiotypes to specific mouse insulin antibodies and as antibodies to the insulin receptor. There was a negative association between the presence of anti-idiotypic receptor antibodies and insulin antibodies bearing the specific idiotype; the specific idiotypic antibodies were confined to the early phase of the primary response while the anti-idiotypic receptor antibodies were detected only after the idiotypic antibodies had disappeared. To map the insulin epitope that triggered the specific idiotypic response, we chemically altered the insulin molecule so as to inhibit its interaction with the insulin receptor. The altered insulins triggered high titers of antibodies binding to antigenic determinants on native insulin, but no anti-idiotypic receptor antibodies. Thus, the epitope responsible for the specific idiotypic-anti-idiotypic network was probably the part of the insulin molecule whose conformation is recognized by the insulin receptor.
Dynamic interactions between L-type voltage-sensitive calcium channel Cav1.2 subunits and ahnak in osteoblastic cells (2009)

Voltage-sensitive Ca(2+) channels (VSCCs) mediate Ca(2+) permeability in osteoblasts. Association between VSCC alpha(1)- and beta-subunits targets channel complexes to the plasma membrane and modulates function. In mechanosensitive tissues, a 700-kDa ahnak protein anchors VSCCs to the actin cytoskeleton via the beta(2)-subunit of the L-type Ca(v)1.2 (alpha(1C)) VSCC complex. Ca(v)1.2 is the major alpha(1)-subunit in osteoblasts, but the cytoskeletal complex and subunit composition are unknown. Among the four beta-subtypes, the beta(2)-subunit and, to a lesser extent, the beta(3)-subunit coimmunoprecipitated with the Ca(v)1.2 subunit in MC3T3-E1 preosteoblasts. Fluorescence resonance energy transfer revealed a complex between Ca(v)1.2 and beta(2)-subunits and demonstrated their association in the plasma membrane and secretory pathway. Western blot and immunohistochemistry showed ahnak association with the channel complex in the plasma membrane via the beta(2)-subunit. Cytochalasin D exposure disrupted the actin cytoskeleton but did not disassemble or disrupt the function of the complex of L-type VSCC Ca(v)1.2 and beta(2)-subunits and ahnak. Similarly, small interfering RNA knockdown of ahnak did not disrupt the actin cytoskeleton but significantly impaired Ca(2+) influx. Collectively, we showed that Ca(v)1.2 and beta(2)-subunits and ahnak form a stable complex in osteoblastic cells that permits Ca(2+) signaling independently of association with the actin cytoskeleton.
The Electrical Properties of Gold Nanoparticle Assemblies Linked by DNA (2000)

Das Halbleiterverhalten von durch DNA verknüpften Goldnanopartikel-Aggregaten hängt über einen Bereich von 24 bis 72 Basenpaaren nicht von der Länge der DNA-Linker ab (siehe Bild; n=1–3). Diese Untersuchung weist darauf hin, dass die Fähigkeit der DNA zur molekularen Erkennung für die Aggregation von Nanopartikel-Materialien genutzt werden kann, ohne dass diese passiviert werden oder ihre strukturellen und elektrischen Eigenschaften verloren gehen.
Spectroelectrochemistry of copper-zinc superoxide dismutase (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpectroelectrochemistry of copper-zinc superoxide dismutaseCynthia Strong St. Clair, Harry B. Gray, and Joan Selverstone ValentineCite this: Inorg. Chem. 1992, 31, 5, 925–927Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://pubs.acs.org/doi/10.1021/ic00031a041https://doi.org/10.1021/ic00031a041research-articleACS PublicationsRequest reuse permissionsArticle Views210Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts