gebhart/patrepeval huggingface dataset:
BTK mediated apoptosis, a possible mechanism for failure to generate high titer retroviral producer clones (2000)

Background It has been shown previously that mutations in the cytoplasmic protein kinase, Bruton's tyrosine kinase (BTK) lead to X-linked agammaglobulinemia, an inherited primary immunodeficiency, thus making it a potential candidate for gene therapy. Methods Producer cell lines using retroviral BTK constructs were generated and retroviral titers determined. Southern blot analysis was performed to check for pro-viral integrity in the respective clones. Furthermore, co-transfection of green fluorescent protein (GFP) with BTK expression plasmids was used in HeLa cells to establish and characterize the role of BTK in apoptosis. Results Following the attempt to generate retroviral producer clones by conventional methods, we observed that the BTK gene is deleted from neomycin-resistant high titer clones. We show that BTK mediated apoptosis in GP#E86 and HeLa cells. Furthermore, membrane targeting and kinase activity are required for this effect. In addition, BTK induced apoptosis could be inhibited by using a specific inhibitor for p38 mitogen-activated protein kinase (MAPK), SB203580. Conclusion Failure to generate retroviral producer clones may be caused by the induction of apoptosis mediated by the therapeutic gene product. Copyright © 2000 John Wiley & Sons, Ltd.
Differential modulation for two-user cooperative diversity systems (2005)

Cooperative transmission is an alternative approach to achieve diversity in wireless systems. So far the research has focused on the situation where perfect channel state information is available and coherent detection is employed at at the destination receiver. This paper proposes a differential modulation scheme for a two-user cooperative diversity system which does not require channel state information at either users or destination. The relaying protocols such as fixed decode-and-forward, selection relaying, and incremental relaying protocols are compared. The proposed scheme achieves spatial diversity gains when the signal-to-noise ratios between cooperative users are sufficiently high.
The Electronic Band -Gap of Polycrystalline Diamond and Tetrahedral Amorphous Carbon by EELS in a STEM. (1999)

Abstract Good quality polycrystalline diamond is transparent and has an optical band-gap very close to that of single crystal diamond, 5.5 eV. Tetrahedral amorphous carbon (ta-C) is a form of amorphous carbon which can have up to 90 % sp3 type bonds. It is the form of amorphous carbon, which is closest to having a true diamond-like structure. The optical band-gap of ta-C is however very different from that of polycrystalline diamond, typically in the range 2-3 eV. This difference in the optical bandgap has been ascribed to the electronic states formed by the residual graphitic bonding. The π − π* states at the graphitic sites effectively form tail states on the valance and conduction band edges created by the diamond-like bonding. These tail states extend deep into the band-gap, which would exist if there were only (100 %) diamond-like bonds. The poor electronic properties obtained thus far for ta-C are now accepted as being associated with localised conduction in the π − π* tail states.
Large-signal temperature-dependent DC model for heterojunction bipolar transistors (1995)

A novel temperature-dependent HBT DC model in a suitable form for implementation in nonlinear circuit simulators is presented. The proposed model is accurate in all operating regions, and its parameters can be extracted easily using suitable optimisation codes. The validity and accuracy of the proposed model are confirmed by comparison to measured DC I-V characteristics of both low-power and high-power devices over a wide temperature range.
Proceedings of the adjunct publication of the 27th annual ACM symposium on User interface software and technology (2014)

It is our pleasure to welcome you to the 27th Annual ACM Symposium on User Interface Software and Technology (UIST), held from October 5-8th 2014, in Honolulu, Hawaii, USA.

UIST is the premier forum for the presentation of research innovations in the software and technology of human-computer interfaces. Sponsored by ACM's special interest groups on computer-human interaction (SIGCHI) and computer graphics (SIGGRAPH), UIST brings together researchers and practitioners from many areas, including web and graphical interfaces, input and output devices, information visualization, sensing technologies, interactive displays, tabletop and tangible computing, interaction techniques, augmented and virtual reality, ubiquitous computing, fabrication, wearable and mobile computing, and computer supported cooperative work.

UIST 2014 received a record 333 technical paper submissions from 34 countries. After a thorough review process, the 36-member program committee accepted 74 papers (22.2%). Each anonymous submission was first reviewed by three external reviewers, and a meta-review was provided by a program committee member. If any of the four reviewers deemed a submission to pass a rejection threshold, we asked the authors to submit a short rebuttal addressing the reviewers' concerns, and a second member of the program committee was asked to examine the paper, rebuttal, and reviews, and to provide their own meta-review. The program committee met in person in Toronto, Ontario, Canada on June 19th and 20th, 2014, to select which papers to invite for the program. Submissions were accepted only after the authors provided a final revision addressing the committee's comments.

In addition to papers submitted directly, the symposium program includes two papers from the ACM Transactions on Computer-Human Interaction journal (TOCHI), as well as 31 posters, 48 demonstrations, and 8 student presentations in the tenth annual Doctoral Symposium. Our program also features the sixth annual Student Innovation Contest. This year, there are 24 teams taking part in the contest, which is focused on household interfaces based on the Kinoma Create platform by Marvell. UIST 2014 will feature two keynote presentations. The opening keynote will be given by Mark Bolas (University of Southern California) on designing the user in the user interface. Bret Victor will deliver the closing keynote on the impact of dynamic media on representation of thought.

Our community has been growing tremendously both in the number of submissions as well as attendees. For the first time, this year's program will be held in two parallel tracks. We hope that you will find our program interesting and thought-provoking and that UIST 2014 will provide you with a valuable opportunity to exchange results at the cutting edge of user interfaces research, to meet friends and colleagues, and to forge future collaborations with other researchers and practitioners from institutions around the world.
Laser acceleration up to black hole values and B-meson decay (2011)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Transformation of boron nitride from cubic to hexagonal under 1-atm helium (2020)

The transformation of boron nitride from the cubic to hexagonal phase has been investigated between 1560 and 1660 °C. High-purity cBN powders of three different particle sizes (<0.5 μm, 2–4 μm and 35–45 μm) were heat treated at ambient pressure in a dry flowing helium atmosphere over this temperature range for up to 8 h. Microscopy reveals surface growth of hBN on the cBN particles, although the morphology and texture of the hBN phase is different between the largest particles (35–45 μm) and the smaller particle sizes (<0.5 μm and 2–4 μm). X-ray diffraction was used to measure the weight fraction of each phase in the powder samples. Transformation rates as measured by weight fraction of the hexagonal phase over time correspond to a zero-order transformation of cBN to hBN, which becomes inhibited as the particle size decreases. Variations in surface growth morphology between the particle sizes suggest growth inhibition due to a reduction in nucleation site availability. Activation energies as determined from Arrhenius plots are 357 ± 29 kJ∙mol−1, 738 ± 168 kJ∙mol−1 and 1490 ± 65 kJ∙mol−1 for the <0.5 μm, 2–4 μm and 35–45 μm, respectively. Increasing surface area of the powders by decreasing the particle size corresponds with both decreased activation energy and collision frequency factor.
Complete Recovery of Fulminant Peripartum Cardiomyopathy on Mechanical Circulatory Support Combined with High-Dose Bromocriptine Therapy (2017)

Peripartum cardiomyopathy (PPCM) is an idiopathic cardiomyopathy presenting with heart failure due to left ventricular systolic dysfunction towards the end of pregnancy or in the months following delivery, where no other cause of heart failure is found. We report a case of a woman with PPCM who developed a critical cardiogenic shock with repeated cardiopulmonary resuscitation. We show for the first time that mechanical circulatory support combined with high-dose bromocriptine therapy to suppress systemic prolactin levels may serve as an effective therapeutic option in patients with fulminant PPCM and cardiogenic shock. Myocardial cathepsin D was overexpressed in our patient underscoring a potential role of cathepsin D-induced cleavage of prolactin in the pathophysiology of PPCM.
Contributions on exploiting transmit and receive diversity for a multi-antenna wireless system (2003)

It is well known that multiple-element antenna arrays can improve the performance and/or data rate of wireless communication systems in a fading environment. Antenna arrays can be employed at the transmitter and/or receiver side creating transmit and/or receive diversity. The aim of this PhD. thesis is to study, develop and combine efficient signal processing and/or coding techniques to exploit transmit and/or receive antenna diversity over wireless fading channels. Consequently, our document is divided in two parts: transmitter side and receiver side. In the first part of our document devoted to transmitter side, we deal especially with Space-Time coding aspects in MIMO (Multi-Input Multi-Output) system and we provide a new Space-Time architecture adapted to CDMA (Coded Division Multiple Access) context. We will examine how far we can go in performance when we use these coding schemes. In the second part of our document -receiver side- on the practical blind identification techniques, specially subspace-based schemes. In this part, we deal with main drawbacks of the subspace identification algorithms such as high computational complexity and lack of robustness to order over-estimation of propagation channel. Herein, we give several algorithms that overcome limitations of this technique. All of these algorithms are validated by simulations.
Composition-Dependent Optoelectronic Properties of Mixed 2D/3D Metal Halide Perovskite Films for Light-Emitting Diodes (2022)

Low-dimensional perovskites with large organic cations have shown great potential for boosting the luminescence efficiency of metal halide perovskite light-emitting diodes (PeLEDs). Although numerous successful results have been obtained for mixed two-dimensional (2D)/three-dimensional (3D) perovskite films, the correlation of the optoelectronic properties with the crystallographic properties and film composition remains elusive. Herein, we investigated the optoelectronic quality of thin films and their impact on luminescence and transport behaviors in a mixed 2D/3D perovskite system containing 2D butylammonium lead bromide (BA2PbBr4) and 3D formamidinium lead bromide (FAPbBr3). Ultrafast transient absorption and temperature-dependent photoluminescence measurements revealed distinct changes in nonemissive decay of the excited states, including the vibrational coupling properties. These behaviors could then be closely correlated with the crystallographic evolution of the perovskite films. We rationalized the performance of PeLED devices and determined the possible limitations to further utilize the advantageous properties of mixed 2D/3D perovskite systems by examining both the luminescence and electrical properties of the perovskite films.
A High‐Performing Solution‐Processed Small Molecule:Perylene Diimide Bulk Heterojunction Solar Cell (2013)

By combining the molecular donor p-DTS(FBTTh2 )2 with a readily produced perylene diimide acceptor we are able to achieve a power conversion efficiency of 3.0%, making this one of the most efficient non-fullerene organic solar cells to date. The reduced power conversion efficiency of the present system compared to the use of phenyl-C71 -butyric acid methyl ester as an electron acceptor is shown to primarily be related to a significant reduction in the internal quantum efficiency. These results indicate the potential of small-molecule:non-fullerene bulk-heterojunction organic photovoltaics.
Evaluation of online emoji description resources for sentiment analysis purposes (2021)

Emoji sentiment analysis is a relevant research topic nowadays, for which emoji sentiment lexica are key assets. Manual annotation affects directly their quality (where high quality usually corresponds to high self-agreement and interagreement).
Comparison of RGB-D sensors for 3D reconstruction (2020)

The use of low-cost RGB-D sensors became popular with the release of Microsoft Kinect V1, in 2010. From that time on, different companies such as ASUS, Orbbec, and Intel have developed their solutions for capturing 3D data. This work proposes an analysis of how well 10 RGB-D sensors perform while applied to a 3D reconstruction task. The comparison was possible by using COMAU's e.Do robotic Arm for ensuring all sensors performed the same set of 3 different paths while capturing RGB and Depth data from the test environment. A customized version of RTAB-map, an open-source solution for real-time appearance-based mapping, was developed so that all ten sensors were supported by the same tool for capturing data, since RTAB-map's original data recorder module did not support Astra Pro device and Realsense devices were not included in the tool. All evaluations were performed in a controlled indoor scenario, built to address different characteristics on the same scene: highly texturized regions, poorly texturized regions, close and far objects. Almost 20GB of data was collected and is available as a public dataset for future comparison of 3D reconstruction algorithms that receive input from different RGB-D sensors.
Instructor Based Training versus Computer Based Training—A Comparative Study (2007)

This article describes two studies conducted to compare assembly performance and learning rate between computer based training and traditional training of skilled assembly operators. The studies were performed with pre-series production parts from a car cockpit and they were integrated as part of the overall training activities during a new vehicle product launch. The computer based training tool used was a desktop based commercial VR tool with focus on cognitive interactive procedural learning. Both studies indicate that computer based training can replace instructor based training for this level of assembly complexity and that it has a positive effect in preparing skilled operators.
Phenotypic Variation in Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 (2004)

Hereditary frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) caused by mutations in the tau gene shows a wide range in age at onset, several distinct clinical presentations, and a spectrum of tau pathology. Although the clinical and pathological phenotype often correlate with the location of the mutation, there also exists considerable interfamilial and intrafamilial phenotypical variation. Not all families with FTDP-17 do have mutations and deposition of hyperphosphorylated tau in the brain, but show ubiquitin-positive, tau-negative inclusions. Future research should focus on the role of other genetic and environmental factors in this form of FTDP-17, whereas the responsible gene defect(s) has still to be identified for hereditary FTD without tau mutations.
The year in cardiovascular medicine 2021: digital health and innovation (2021)

This article presents some of the most important developments in the field of digital medicine that have appeared over the last 12 months and are related to cardiovascular medicine. The article consists of three main sections, as follows: (i) artificial intelligence-enabled cardiovascular diagnostic tools, techniques, and methodologies, (ii) big data and prognostic models for cardiovascular risk protection, and (iii) wearable devices in cardiovascular risk assessment, cardiovascular disease prevention, diagnosis, and management. To conclude the article, the authors present a brief further prospective on this new domain, highlighting existing gaps that are specifically related to artificial intelligence technologies, such as explainability, cost-effectiveness, and, of course, the importance of proper regulatory oversight for each clinical implementation.
An Empirical vs Risk-Based Approach Algorithm to Intracavernosal Injection Therapy: A Prospective Study (2017)

Empiric and risk-based strategies for ICI therapy resulted in significant improvements across multiple domains of sexual function. Complication rates, satisfaction, and efficacy overall were similar between the two approaches. Clinicians can be reassured that no one approach to ICI therapy for ED management appears inferior to another.
A liposomal RNA vaccine inducing neoantigen-specific CD4 + T cells augments the antitumor activity of local radiotherapy in mice (2020)

Antigen-encoding, lipoplex-formulated RNA (RNA-LPX) enables systemic delivery to lymphoid compartments and selective expression in resident antigen-presenting cells. We report here that the rejection of CT26 tumors, mediated by local radiotherapy (LRT), is further augmented in a CD8<sup>+</sup> T cell-dependent manner by an RNA-LPX vaccine that encodes CD4<sup>+</sup> T cell-recognized neoantigens (CD4 neoantigen vaccine). Whereas CD8<sup>+</sup> T cells induced by LRT alone were primarily directed against the immunodominant gp70 antigen, mice treated with LRT plus the CD4 neoantigen vaccine rejected gp70-negative tumors and were protected from rechallenge with these tumors, indicating a potent poly-antigenic CD8<sup>+</sup> T cell response and T cell memory. In the spleens of CD4 neoantigen-vaccinated mice, we found a high number of activated, poly-functional, Th1-like CD4<sup>+</sup> T cells against ME1, the immunodominant CD4 neoantigen within the poly-neoantigen vaccine. LRT itself strongly increased CD8<sup>+</sup> T cell numbers and clonal expansion. However, tumor infiltrates of mice treated with CD4 neoantigen vaccine/LRT, as compared to LRT alone, displayed a higher fraction of activated gp70-specific CD8<sup>+</sup> T cells, lower PD-1/LAG-3 expression and contained ME1-specific IFNγ<sup>+</sup> CD4<sup>+</sup> T cells capable of providing cognate help. CD4 neoantigen vaccine/LRT treatment followed by anti-CTLA-4 antibody therapy further enhanced the efficacy with complete remission of gp70-negative CT26 tumors and survival of all mice. Our data highlight the power of combining synergistic modes of action and warrants further exploration of the presented treatment schema.
Mechanism of CO Adsorption on Pt-Ru Fuel Cell Anode Catalysts (2006)

Abstract not Available.
Characterization of the acoustic output of single marine-seismic airguns and clusters: The Svein Vaage dataset (2021)

The acoustical output of marine-seismic airguns is determined from recordings of the sound pressure made on hydrophones suspended below a floating barge from which the airguns are also deployed. The signals from multiple types of airguns are considered and each type is operated over a range of deployment depths and chamber pressures. The acoustical output is characterized in terms of a "source waveform" with dimensions of the pressure-times-distance and in an infinite idealized medium, could be divided by the source-receiver distance to give the sound pressure at that receiver. In more realistic environments, the source waveform may be used to predict the pressure at any arbitrary receiver position simply by the application of a time-domain transfer function describing the propagation between the source and receiver. The sources are further characterized by metrics such as the peak source waveform and energy source level. These metrics are calculated in several frequency bands so that the resulting metrics can be used to characterize the acoustical output of the airguns in terms of their utility for seismic image-processing or possible effects on marine life. These characterizations provide reference data for the calibration of models that predict the airguns' acoustical output. They are validated via comparisons of the acoustic pressure measured on far-field hydrophones and predicted using the source waveforms. Comparisons are also made between empirically derived expressions relating the acoustic metrics to the chamber volume, chamber pressure, and deployment depth and similar expressions from the literature.
Ermittlung und Bewertung von Einsatzpotenzialen der Mensch-Roboter-Kollaboration (2021)

Abstract Aufgrund des starken Kostendrucks sowie der immer weiter steigenden Variantenvielfalt stellt die Kollaboration von Mensch und Roboter einen möglichen Lösungsvektor für weitere Flexibilisierungs- und Rationalisierungspotenziale in der Montage dar. Die gezielte Ermittlung und Bewertung von Einsatzpotenzialen bildet in der Praxis die Grundlage für den erfolgreichen Einsatz von kollaborativen Robotern. In diesem Beitrag wird ein Vorgehensmodell für die methodische Analyse des Einsatzes von kollaborativen Robotern in Montageszenarien vorgeschlagen und evaluiert. *)
A grid workflow-based Monte Carlo simulation environment (2004)

Monte Carlo methods provide enormous scope for realistic statistical modeling and simulation. Implementation of large-scale Monte Carlo applications on the grid benefits from state-of-the-art approaches to accessing resources in a computational grid. Workflow techniques allow one to describe and enact his simulation processes in a structured, manageable, and verifiable way. We developed the Grid-Computing Infrastructure for Monte Carlo Applications (GCIMCA) based on the Globus toolkit and SPRNG library. The Globus toolkit facilitates creation and utilization of a computational grid for large distributed computational jobs and the Scalable Parallel Random Number Generators (SPRNG) library is designed to generate practically infinite number of random number streams with favorable statistical properties for distributed Monte Carlo applications. GCIMCA provides services specific to grid-based Monte Carlo simulation applications, including the Monte Carlo subtask schedule service using the N-out-of-M strategy, the facilities of application-level checkpointing, the partial result validation service, and the intermediate value validation service. Taking advantage of grid workflow paradigms and GCIMCA facilities, we implemented a Grid Workflow-based Monte Carlo (GWMC) simulation environment. Workflow management services are implemented to manage the Monte Carlo simulation process. We intend to provide a trustworthy and manageable grid-computing environment for large-scale and high-performance Monte Carlo simulation application.