gebhart/patrepeval huggingface dataset:
Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA (2016)

Recently, we showed the adenovirus proteinase interacts productively with its protein substrates in vitro and in vivo in nascent virus particles via one-dimensional diffusion along the viral DNA. The mechanism by which this occurs has heretofore been unknown. We show sliding of these proteins along DNA occurs on a new vehicle in molecular biology, a 'molecular sled' named pVIc. This 11-amino acid viral peptide binds to DNA independent of sequence. pVIc slides on DNA, exhibiting the fastest one-dimensional diffusion constant, 26±1.8 × 10(6) (bp)(2) s(-1). pVIc is a 'molecular sled,' because it can slide heterologous cargos along DNA, for example, a streptavidin tetramer. Similar peptides, for example, from the C terminus of β-actin or NLSIII of the p53 protein, slide along DNA. Characteristics of the 'molecular sled' in its milieu (virion, nucleus) have implications for how proteins in the nucleus of cells interact and imply a new form of biochemistry, one-dimensional biochemistry.
A Catalytic Asymmetric Suzuki Coupling for the Synthesis of Axially Chiral Biaryl Compounds (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA Catalytic Asymmetric Suzuki Coupling for the Synthesis of Axially Chiral Biaryl CompoundsJingjun Yin and Stephen L. BuchwaldView Author Information Department of Chemistry Massachusetts Institute of Technology Cambridge, Massachusetts 02139 Cite this: J. Am. Chem. Soc. 2000, 122, 48, 12051–12052Publication Date (Web):November 11, 2000Publication History Received19 September 2000Published online11 November 2000Published inissue 1 December 2000https://pubs.acs.org/doi/10.1021/ja005622zhttps://doi.org/10.1021/ja005622zrapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views12131Altmetric-Citations409LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Anions,Aromatic compounds,Ligands,Palladium,Stereoselectivity Get e-Alerts
Nanostructure Dependence of Conductive Polymer Chemical Sensors (2006)

It is shown that the resistive sensing properties of conductive polymers are highly dependent on the material nanostructure. The sensing properties of regioregular poly(3-hexylthiophene) (P3HT) polymer thin films with porous nanofibrile structure, dense nanofibrile structure and nano-granular structure show very different conductance changes, in terms of both response amplitude and sign, upon exposure to various VOC vapors. This implies that multiple sensing mechanisms, such as both grain boundary and intra-grain effects, exist and the dominant sensing mechanism can vary with different material nanostructures. Possible mechanisms for these effects, and their correlation with observed material nanostructures, are also discussed.
A Novel Method of Beryllium Window Protection in a Plasma Focus Soft X-Ray Source (1992)

A significant problem of plasma X-ray sources such as a plasma focus device is how to protect the very thin beryllium window from damage and contamination caused by the bombardment of plasma particles. Improvement of the protection of the beryllium window has been made by inserting a magnetic deflector between the focused plasma and the window and by inverting the polarity of the applied voltage to the electrodes. As a result, a 13-µm-thick beryllium membrane can be used safely. The measured X-ray intensity is about 5 mW/cm 2 30 cm from the source operated at 3.5 kJ discharge energy. The achieved intensity is suitable for R&amp;D application in X-ray lithography.
A 65nm test structure for the analysis of NBTI induced statistical variation in SRAM transistors (2008)

We present the results of a test structure that allows to measure the variation of SRAM p-MOS and n-MOS transistors in a dense environment and to apply Negative Bias Temperature Instability (NBTI) stress on the p-MOS transistors. The threshold voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> ) and drain current (I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</sub> ) distributions of p-MOS SRAM transistors pre and post NBTI Stress are measured and analyzed. The probability density functions (PDF) of both transistor parameters V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> and I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</sub> follow a Gaussian distribution pre and post NBTI stress, but the difference in the transistor parameters of an individual device is not Gaussian distributed. The standard deviation in the difference of V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> is about 50% of the mean for the small SRAM p-MOS transistor. The impact of the additional variation induced by NBTI stress is shown for the Static Noise Margin of a 6-T SRAM cell.
Interleukin‐18 Inhibits Human Immunodeficiency Virus Type 1 Production in Peripheral Blood Mononuclear Cells (2001)

Interleukin (IL)-18 is an interferon (IFN)-gamma-inducing factor and contributes to the Th1 immune response. IL-18 added after infection of peripheral blood mononuclear cells (PBMC) with monocyte-tropic human immunodeficiency virus type 1 (HIV-1) inhibited p24 antigen production by a maximum of 72%. IFN-gamma levels in these cultures were increased, and a significant inverse relationship between HIV-1 production and IFN-gamma levels was observed. A neutralizing anti-IFN-gamma antibody reversed the IL-18 inhibitory effect. Preincubation of PBMC with IL-18 before infection inhibited p24 without additional IL-18 (64%). However, compared with the degree of IL-18 inhibition observed after a 4-day culture, no additional IL-18 inhibitory effect was observed during days 5-13. IL-18 also reduced cell surface expression of the HIV-1 receptor CD4. These results demonstrate that IL-18 inhibited HIV-1 production in PBMC through intermediate IFN-gamma. Furthermore, inhibition was present during the early stages of viral infection and was associated with reduced HIV-1 receptor expression.
Magnetic nanoparticles as a seed layer for growing ZnO nanowires for optical applications (2013)

In the present work, cerium oxide CeO2 nanoparticles were synthesised by sol-gel method and used for the growth of ZnO nanorods. The synthesised nanoparticles were studied by x-ray diffraction technique [XRD]. Furthermore, these nanoparticles were used as seed layer for the growth of ZnO nanorods by following the hydrothermal growth method. The structural study of ZnO nanorods was carried out by using field emission scanning electron microscopy [FESEM], and x-ray diffraction [XRD] techniques. This study demonstrated that the grown ZnO nanorods are well align, uniform, good in crystal quality and possess diameter of less than 200 nm. Energy dispersive x-rays [EDX] revealed that the ZnO nanorods are only composed of zinc, cerium as seed atom and oxygen atoms and no any other impurity in the grown nanorods. Moreover, photoluminescence [PL] approach was applied for the optical characterisation and it was observed that the near-band-edge emission [NBE] was same to that of zinc acetate seed layer, however the green emission and orange/red emission peaks were slightly raised due to possible higher level of defects in the cerium oxide seeded ZnO nanorods. This study provides an alternative approach for the synthesis of controlled ZnO nanorods using cerium oxide nanoparticles as seed nucleation layer which in reverse describe the application of these nanoparticles as well as due to controlled morphology of ZnO nanorods the performance of nanodevices based on ZnO can be increased using these particles as seed.
The covalent protein structure of insecticyanin, a blue biliprotein from the hemolymph of the tobacco hornworm, Manduca sexta L. (1984)

The amino acid sequence has been determined for the insecticyanin from the hemolymph of the fifth instar larvae of the tobacco hornworm, Manduca sexta. The apoprotein is a single polypeptide chain of 189 amino acids, molecular weight 21,378, containing two disulfide bridges, 9-119 and 42-176. The sequence analysis was performed by automated Edman degradation of reduced and carboxymethylated insecticyanin and fragments generated therefrom by cyanogen bromide, trypsin, chymotrypsin, and Staphylococcus aureus proteinase. Most of the peptides were purified by reverse-phase high-performance liquid chromatography. A purification procedure for the isolation of insecticyanin in high yields and a simple method of determining disulfide linkages are also reported.
Appendix C: VHDL Source Code (2005)

This appendix contains sections titled: DCO Level 2 Period-Controlled Oscillator Tactical Flip-Flop TDC Pseudo-Thermometer Output Decoder
Generation of Melamine Polymer Condensates upon Hypergolic Ignition of Dicyanamide Ionic Liquids (2011)

Die Reaktion von ionischen Flüssigkeiten mit Dicyanamid-Ionen mit Salpetersäure hat eine hypergole Zündung und die Bildung eines stabilen Niederschlags zur Folge. Dieser besteht aus cyclischen Triazinen, darunter Melamin und seine Polymere wie Melam und Melem (siehe Schema). Diese Studie führt einen neuen Syntheseansatz für cyclische Azine ein, der hohe Temperaturen und Drücke umgeht. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Novel Functional Groups with Fine-Controlled Metal Assembling Function (2005)

Abstract Half-substituted dendritic phenylazomethine dendrimers with various substituents (Half-DPA-X Gn, where n is the generation number) were synthesized in order to elucidate the electron gradients in the dendrons by complexation with metal ions. Along with the change in the UV–vis spectra, the isosbestic point shifted about 11 nm from 371 to 360 nm. The number of added equivalents of SnCl2 required to induce a shift was in agreement with the number of the imine sites present in each layer of Half-DPA-H G4. The degree of the electron gradient in the phenylazomethine monodendrons, Half-DPAs, was estimated via titration with trifluoroacetic acid. We found drastic differences in the basicity of the imine sites; the basicity of the core imines is higher than that of the more peripheral imines. The stepwise complexation behavior is thermodynamically controlled from the core to terminal imines in Half-DPA-H. Furthermore, Half-DPA G4 with various substituents possesses the same electron gradients in the dendron, so the complexation behavior with metal ions is the same.
Neutrophil Extracellular Traps in Colorectal Cancer Progression and Metastasis (2021)

Neutrophils form sticky web-like structures known as neutrophil extracellular traps (NETs) as part of innate immune response. NETs are decondensed extracellular chromatin filaments comprising nuclear and cytoplasmic proteins. NETs have been implicated in many gastrointestinal diseases including colorectal cancer (CRC). However, the regulatory mechanisms of NET formation and potential pharmacological inhibitors in the context of CRC have not been thoroughly discussed. In this review, we intend to highlight roles of NETs in CRC progression and metastasis as well as the potential of targeting NETs during colon cancer therapy.
Towards a canine-human communication system based on head gestures (2015)

We explored symbolic canine-human communication for working dogs through the use of canine head gestures. We identified a set of seven criteria for selecting head gestures and identified the first four deserving further experimentation. We devised computationally inexpensive mechanisms to prototype the live system from a motion sensor on the dog's collar. Each detected gesture is paired with a predetermined message that is voiced to the humans by a smart phone. We examined the system and proposed gestures in two experiments, one indoors and one outdoors. Experiment A examined both gesture detection accuracy and a dog's ability to perform the gestures using a predetermined routine of cues. Experiment B examined the accuracy of this system on two outdoor working-dog scenarios. The detection mechanism we presented is sufficient to point to improvements into system design and provide valuable insights into which gestures fulfill the seven minimum criteria.
Distributed sensor resource management and planning (2007)

The goal of sensor resource management (SRM) is to allocate resources appropriately in order to gain as much information as possible about a system. In our previous paper, we introduced a centralized non-myopic planning algorithm, C-SPLAN, that uses sparse sampling to estimate the value of resource assignments. Sparse sampling is related to Monte Carlo simulation. In the SRM problem we consider, our network of sensors observes a set of tracks; each sensor can be set to operate in one of several modes and/or viewing geometries. Each mode incurs a different cost and provides different information about the tracks. Each track has a kinematic state and is of a certain class; the sensors can observe either or both of these, depending on their mode of operation. The goal is to maximize the overall rate of information gain, i.e. rate of improvement in kinematic tracking and classification accuracy of all tracks in the Area of Interest. We compared C-SPLAN's performance on several tracking and target identification problems to that of other algorithms. In this paper we extend our approach to a distributed framework and present the D-SPLAN algorithm. We compare the performance as well as computational and communications costs of C-SPLAN and D-SPLAN as well as near-term planners.
Absolute Configuration of the Cancerostatic S(–)‐Isophosphamide (1980)

Structure/activity relations in chiral drugs can only be studied if the absolute configuration is known. The levorotatory form of the cancerostatic isophos‐phamide is shown by X‐ray structure analysis to have the S configuration.
ChemInform Abstract: Sulfhydrolysis of Acyl Ketene Dithioacetals: A Convenient Synthesis of β‐Oxodithioesters. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Bone Regeneration in Defects Compromised by Radiotherapy (2009)

Because bone reconstruction in irradiated sites is less than ideal, we applied a regenerative gene therapy method in which a cell-signaling virus was localized to biomaterial scaffolds to regenerate wounds compromised by radiation therapy. Critical-sized defects were created in rat calvariae previously treated with radiation. Gelatin scaffolds containing lyophilized adenovirus encoding BMP-2 (AdBMP-2) or freely suspended AdBMP-2 were transplanted. Lyophilized AdBMP-2 significantly improved bone quality and quantity over free AdBMP-2. Bone mineral density was reduced after radiotherapy. Histological analyses demonstrated that radiation damage led to less bone regeneration. The woven bone and immature marrow formed in the radiated defects indicated that irradiation retarded normal bone development. Finally, we stored the scaffolds with lyophilized AdBMP-2 at -80 degrees C to determine adenovirus stability. Micro-CT quantification demonstrated no significant differences between bone regeneration treated with lyophilized AdBMP-2 before and after storage, suggesting that virus-loaded scaffolds may be convenient for application as pre-made constructs.
Liquid Crystal Cells for Blazed Grating Steering Devices. (1999)

Two types of non-mechanical liquid crystal laser beam steering devices were developed. The first is a prismatic refractive device with a smectic liquid crystal wedge as a passive light deflector and twisted nematic flat cell as an optical switch. The prismatic device has constant deflected beam intensity for all deflection angles (several degrees) and works in the (1-10) ms range of the response times. The other type is based on electrically controlled cholesteric diffraction gratings. The cholesteric grating is a phase grating capable of both Bragg and Raman-Nath diffraction and two modes of operation: simple electric switching between non-diffractive and diffractive regimes; continuous beam steering up to 20 degrees. This devices works in the (10-100) ms range of the response times.
Advanced Data Acquisition Methods for Quantitative Single Photon Emission CT (1984)

This paper proposes some advanced data acquisition methods for quantitative single photon emission CT. One example of such methods is the odd number angular sampling method over 360 degrees for a widely distributed object, and the other is fine angular sampling of 180 degrees for a nonsymmetrically localized small object in an attenuation cross section. The image quality, such as the spatial resolution and the signal-to-noise ratio, becomes better than that reconstructed from conventional conjugate projection data. The reconstruction technique used in computer simulation is the iterative correction matrix method, but other techniques are also applicable. Comparison between the weighted back projection method and the correction matrix method is also presented.
Antitumor Activity and Immune Response Induction of a Dual Agonist of Toll-Like Receptors 7 and 8 (2010)

Viral and synthetic single-stranded RNAs are the ligands for Toll-like receptors 7 and 8 (TLR7 and TLR8). We have reported a novel class of synthetic oligoribonucleotides, referred to as stabilized immune-modulatory RNA compounds, which act as agonists of TLR7, TLR8, or both TLR7 and TLR8 depending on the sequence composition and the presence of specific chemical modifications. In the present study, we evaluated the antitumor activity of a dual TLR7/8 agonist in tumor-bearing mice with peritoneal disseminated CT26.CL25 colon and 3LL-C75 lung carcinomas. Peritoneal administration of dual TLR7/8 agonist in mice bearing CT26.CL25 colon carcinomas had potent dose-dependent antitumor activity, which was associated with a marked decrease in CD4(+)CD25(+)Foxp3(+) T regulatory cells and a significant increase in tumor antigen-specific IFN-gamma-secreting effector cell responses in splenocytes and local tumor-infiltrating cells. In 3LL-C75 lung carcinoma, dual TLR7/8 agonist induced strong immune responses and antitumor effects in C57BL/6 and TLR9(-/-) mice, but not in TLR7(-/-) and MyD88(-/-) mice, indicating that the agonist induces immune responses via TLR7 and through the MyD88-dependent signaling pathway. TLR8 is not functional in mice. Additionally, s.c. administration of TLR7/8 agonist effectively prevented lung metastasis of tumors in the CT26.CL25 pulmonary metastasis model. These studies show that the dual TLR7/8 agonist induced Th1-type immune responses and potent antitumor activity in mice via TLR7 and through the MyD88-dependent pathway.
Numerical Investigation of Shock Effects on Performance and Flow Field in a Transonic Centrifugal Impeller (2016)

In transonic centrifugal compressors, the losses and blockage are increased dominantly by the shock, shock/tip leakage vortex (TLV) interaction and shock/boundary layers interaction on the blade suction side. Therefore, a detailed investigation of shock effects is seriously important to improve the aerodynamic performance and extend the stable operating range of a centrifugal compressor. This paper firstly analyzes the shock structures in the transonic impeller at the design and off-design conditions. It is found that the shock structure is three-dimensional and swept along the span, with the shock becoming normal to the shroud near the blade tip. As the mass flow rate decreases, the swept shock moves upstream, and the shock/TLV interaction becomes stronger, inducing the vortex breakdown at the near stall condition. Then a comparative study is conducted on the flow structures in the transonic centrifugal impeller without the tip clearance (OTC impeller). Compared with the impeller with a tip clearance (WTC impeller), the splitter shock strength in the passage between the main blade and splitter is enhanced and the separation caused by the splitter shock /boundary layers interaction is induced, due to the lack of the blockage in the inducer induced by the shock/TLV of main blade interaction in the WTC impeller. Thus, at a large mass flow rate, the efficiency of the OTC impeller is lower than that of the WTC impeller because the stronger splitter shock induces larger flow separation in the passages between the main blade and splitter. However, at a small mass flow rate, the WTC impeller has a lower efficiency because the losses in the inducer induced by the interaction between the shock and the TLV of main blade are dominant.
67 Analysis of Mixture Conditions in a Small Two Stroke Engine Using a Gas Sampling Valve (2002)

&lt;div class="htmlview paragraph"&gt;The quality of mixture formation and the combustion process is of significant importance for reducing the hydrocarbon emissions of small two stroke engines. The scope of this work was to investigate the mixture conditions after the exhaust closes and after the end of combustion depending on various engine operating points. For this experimental investigation a Gas Sampling Valve (GSV) was combined with a flame ionisation detector (FID) and a CO&lt;sub&gt;2&lt;/sub&gt;-analyser. Using this technique, it was possible to measure the hydrocarbon concentration after end of combustion. Furthermore the local residual gas concentration after exhaust closes was determined.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;To allow for a comparison of the experimental results with calculations with CFD codes, in cylinder pressure measurement and exhaust gas measurements are done additionally.&lt;/div&gt;
On-Chip Nanoscopy (2018)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Ø. I. Helle, D. A. Choucheron, C. I. Øie, J. Tinguely, and B. S. Ahluwalia, "On-Chip Nanoscopy," in Latin America Optics and Photonics Conference, OSA Technical Digest (Optica Publishing Group, 2018), paper Th2A.4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article