gebhart/patrepeval huggingface dataset:
Cognitive Distributed Computing and Its Impact on Information Technology (IT) as We Know It (2017)

As the scale of computations become large and as both people and machines demand communication, collaboration and commerce at the speed of light, rapid fluctuations in the demand for computing performance and fluctuations in available resource pools, both make it necessary to respond fast and readjust the computation structures and associated resources so as to not disrupt the user experience or the service transaction. Current Information Technologies from their memory-starved, server-centric, low-bandwidth origins from von Neumann’s stored program control implementation of the Turing Machine are evolving with new architectures to meet the demand for scale and speed. In this paper we discuss the evolution of current IT to cognitive IT, where computing processes become self-aware of their resource requirements in real-time and seek to adjust them from a global knowledge of available resource pools and their provisioning processes. This is transforming the current state of the IT as we know it to a cognitive IT.
Numerical Modeling and High Speed Parallel Computing: New Perspectives for Tomographic Microwave Imaging for Brain Stroke Detection and Monitoring (2016)

This article deals with microwave tomography for brain stroke imaging using state-of-the-art numerical modeling and massively parallel computing. Iterative microwave tomographic imaging requires the solution of an inverse problem based on a minimization algorithm (e.g., gradient based) with successive solutions of a direct problem such as the accurate modeling of a whole-microwave measurement system. Moreover, a sufficiently high number of unknowns is required to accurately represent the solution. As the system will be used for detecting a brain stroke (ischemic or hemorrhagic) as well as for monitoring during the treatment, the running times for the reconstructions should be reasonable. The method used is based on high-order finite elements, parallel preconditioners from the domain decomposition method and domain-specific language with the opensource FreeFEM-solver.
An Examination of Cytomegalovirus, Socioeconomic Status, Race, and Ethnicity on Outcomes after Haploidentical Hematopoietic Transplantation (2020)

Previous analyses of the effects of race and socioeconomic status (SES) on outcomes after hematopoietic stem cell transplantation (HSCT) have suggested that minority populations and those in disadvantaged groups have inferior outcomes. However, the results of these studies have been inconsistent, potentially due to a multitude of factors, both medical and nonmedical, that have confounded results. In haploidentical (HI) HSCT, an expanding approach with the potential to enfranchise more minority patients, data on the effect of race and SES on outcomes are very limited. To identify and potentially correct factors that negatively impact outcomes after HI HSCT in disadvantaged groups at our institution, we performed a retrospective, multivariable analysis of the impact of race and SES as single and combined variables on HI HSCT outcomes of relapse, transplantation-related mortality, acute and chronic graft-versus-host disease (GVHD), and overall survival (OS). In addition to controlling for race and SES, all patients had HI donors and were treated with the same 2-step approach, with consistent T cell dosing and GVHD prophylaxis to further reduce the impact of confounders in this complex area. The study cohort of 239 patients was 71% Caucasian, 19.7% African American, 4.6% Hispanic, and 4.2% Asian. The majority of minority patients were in areas of higher deprivation (P = .001) and had the highest incidence of cytomegalovirus (CMV) seropositivity (P = .001) and the lowest likelihood of possessing a CMV immunodominant (IMD) allele (P = .001), which was previously associated with an OS benefit. Positive CMV serostatus was highly linked to post-transplantation CMV reactivation (P = .001) which was associated with higher relapse rates (hazard ratio [HR], 1.56; 95% confidence interval [CI], 1.06 to 2.30; P = .026), higher TRM (HR, 2.10; 95% CI, 1.09 to 4.05; P = .027), and lower OS (HR, 1.77; 95% CI, 1.18 to 2.65; P = .006). The lack of a CMV IMD allele largely replicated the results of CMV reactivation on HSCT results. Although race and SES did not directly correlate with either OS or relapse incidence, non-Caucasians in a more disadvantaged group had a higher incidence of chronic GVHD (HR, 2.55; 95% CI, 1.08 to 6.01; P = .033) compared with Caucasians and minorities in less disadvantaged groups. Regardless of SES, minorities had a lower incidence of acute GVHD than Caucasians in a more advantaged SES group (HR, 0.52; 95% CI, 0.30 to 0.90; P = .020). The primary finding of this study is that CMV reactivation was the major driver of mortality after HI HSCT. CMV reactivation may have be associated with poor HSCT outcomes in HI HSCT recipients in disadvantaged areas, most of whom were minorities. The data suggest that the prevention of post-transplantation CMV reactivation possibly could have a major impact on HI HSCT outcomes, especially in minority recipients. The finding of different GVHD manifestations between races are intriguing and merits further study.
Antigenic analysis of potato virus A particles and coat protein (1994)

Summary Five monoclonal antibodies (MAbs) were prepared to particles of potato virus A (PVA), isolate B11. In immunoblots, MAbs A1D8 and A5B6 reacted only with full length molecules of PVA coat protein (CP). Pepscan tests with overlapping octapeptides representing the whole sequence of PVA CP showed that the epitope detected by MAb A5B6 is contained in its N‐terminal octapeptide. MAbs A9A4, A3H4 and A6B8 reacted with CP molecules that lacked about 5 kD of sequence at their end(s) and detected epitopes at residues 52 to 62, 64 to 73 and 75 to 82 respectively, all of which lie in the protease‐resistant core of the CP. The epitope which reacts with MAb A3H4 is in a region predicted to be hydrophobic and is not detected in intact virus particles, indicating it is a cryptotope. In contrast, MAbs A6B8 and A9A4 reacted with freshly purified PVA particles but more strongly with partially degraded ones. Pepscan tests with polyclonal antibodies to PVA isolate B11 identified five additional immunogenic sequences in PVA CP and showed that regions at the N‐termini of the intact and core molecules are immunodominant. PVA isolate B11 was not transmitted by aphids, and its CP N‐terminal octapeptide contains the sequence DAS, which is associated with aphid‐non‐transmissibility in other potyviruses. MAb A5B6, which detects this region, reacted strongly in ELISA with three out of four other aphid‐non‐transmissible PVA isolates but only weakly with three aphid‐transmissible ones, suggesting that differences in N‐terminal sequence may underlie most of the differences in aphid transmissibility.
Managing Service Quality at the Platform and Application Levels with rSLa (2016)

Managing service quality in heterogeneous Cloud environments is complex: different providers expose different management interfaces for monitoring and configuration actions that can occur at the infrastructure, platform and application levels. To manage Service Level Agreements (SLAs) in this context, we have developed the rSLA Manager for enabling fast setup of SLA monitoring in dynamic, heterogeneous Cloud environments. In this paper, we demonstrate the use of the rSLA Manager to manage the response time behavior of an image scaling service on the IBM Blue mix platform. We show how the system enables SLA violation reduction by facilitating platform-level adaptation (e.g., adding application instances) and application-level behavior configuration (e.g., changing image scaling quality) based on different service level objectives as well as current application configuration and workload.
ChemInform Abstract: Synthesis of New Building Blocks for Peptide Nucleic Acids Containing Monomers with Variations in the Backbone. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Characterization of a monoclonal antibody against the lymphoblast substance P receptor. (1987)

A murine monoclonal antibody to the IM-9 lymphoblast substance P (SP) receptor has been produced which recognizes the membrane-associated proteins of the SP receptor as demonstrated by immunoprecipitation of [125I]SP affinity-labeled and [35S]methionine biosynthetically labeled IM-9 soluble membranes. SP and anti-SP receptor binding to [35S]methionine-labeled IM-9 cell proteins were directly compared by attachment of each to affinity supports. Eluants from these affinity columns were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and revealed an equivalent 33-kDa protein in both cases. This protein corresponds to one of the previously described [125I]SP specifically affinity-labeled membrane-associated proteins. In addition, two-color fluorescence-activated cell sorter analysis with human peripheral blood T lymphocytes with fluorescein-SP and rhodamine-labeled antireceptor antibody revealed a distinct population of cells (20 to 30%) that were equally labeled by both the fluorescent peptide and antibody. This result indicates that the anti-SP receptor antibody recognizes an epitope of the receptor that is common to both human peripheral blood T lymphocytes and IM-9 lymphoblast cells.
Liver-ultrasound-guided lung tumour tracking for scanned proton therapy: a feasibility study (2020)

Abstract Pencil beam scanned (PBS) proton therapy of lung tumours is hampered by respiratory motion and the motion-induced density changes along the beam path. In this simulation study, we aim to investigate the effectiveness of proton beam tracking for lung tumours both under ideal conditions and in conjunction with a respiratory motion model guided by real-time ultrasound imaging of the liver. Multiple-breathing-cycle 4DMRIs of the thorax and abdominal 2D ultrasound images were acquired simultaneously for five volunteers. Deformation vector fields extracted from the 4DMRI, referred to as ground truth motion, were used to generate 4DCT(MRI) data sets of two lung cancer patients, resulting in 10 data sets with variable motion patterns. Given the 4DCT(MRI) and the corresponding ultrasound images as surrogate data, a patient-specific motion model was built. The model consists of an autoregressive model and Gaussian process regression for the temporal and spatial prediction, respectively. Two-field PBS plans were optimised on the reference CTs, and 4D dose calculations (4DDC) were used to simulate dose delivery for (a) unmitigated motion, (b) ideal 2D and 3D tracking (both beam adaption and 4DDC based on ground truth motion), and (c) realistic 2D and 3D tracking (beam adaption based on motion predictions, 4DDC on ground truth motion). Model-guided tracking retrieved clinically acceptable target dose homogeneity, as seen in a substantial reduction of the D5%–D95% compared to the non-mitigated simulation. Tracking in 2D and 3D resulted in a similar improvement of the dose homogeneity, as did ideal and realistic tracking simulations. In some cases, however, the tracked deliveries resulted in a shift towards higher or lower dose levels, leading to unacceptable target over- or under-coverage. The presented motion modelling framework was shown to be an accurate motion prediction tool for the use in proton beam tracking. Tracking alone, however, may not always effectively mitigate motion effects, making it necessary to combine it with other techniques such as rescanning.
Inductance Model-based Sensorless SRM Drive with Torque Ripple Minimization (2018)

An inductance model-based sensorless control strategy with torque ripple and acoustic noise minimization for switched reluctance machines is proposed. In order to simultaneously reduce the torque ripple and acoustic noise, a specific-shaped current waveform that is needed and obtained from a torque-sharing function (TSF) is used in this paper. With the inductance model-based sensorless control strategy and the specific-shaped current modulation, the any rotor position within the entire electrical angle can be calculated by the bisection algorithm so that a specific current profiling can be obtained and therefore torque ripple and acoustic noise minimization can be achieved. The traditional trapezoid-shaped current modulation is compared with the specific current profiling in term of torque ripple. A 2 kW 12/8 SRM sensorless drive is modelled using the PSIM software. The simulated results indicate that the new sensorless control strategy is effective in reducing torque ripple. A hardware prototype of 2 kW converter with TMS320F28335 is also constructed and tested. The experimental results indicate that the new sensorless control strategy is effective in rotor position estimation.
CYP2J2 overexpression ameliorates hyperlipidemia via increased fatty acid oxidation mediated by the AMPK pathway (2015)

Endothelial-specific CYP2J2 overexpression alleviates HFD-induced hyperlipidemia in vivo. CYP2J2 ameliorates FFA-induced dyslipidemia via increased fatty acid oxidation mediated by the AMPK and PPARα pathways.
Enhanced performance in uncooled n-CdSe/p-PbSe photovoltaic detectors by high-temperature chloride passivation (2022)

High-temperature chloride passivation (HTCP) was proposed to improve the crystalline quality and electrical properties of PbSe epitaxial films. The PL intensity of HTCP (111) PbSe epitaxial films exhibits a 14 times higher intensity than that of as-grown films, and a threefold increase in Hall mobility has been obtained after HTCP at 300 °C for 2 h. The improvement of optical and electrical properties is attributed to the high-temperature defect passivation induced by the HTCP process. The HTCP process of PbSe films was implemented in a CdSe/PbSe heterojunction PV detector, which exhibits a room temperature peak detectivity <i>D</i>* of 8.5 × 10<sup>8</sup> cm Hz<sup>1/2</sup> W<sup>-1</sup> in the mid-wavelength infrared region under blackbody radiation (227 °C), demonstrating potential applications in the fabrication of mid-infrared detectors and emitters.
Comments on "A limitation on frequency of Gunn effect due to the intervalley scattering time" (1969)

A correction to a limitation on frequency of Gunn oscillations is suggested.
Efficient Decomposition of Image and Mesh Graphs by Lifted Multicuts (2015)

Formulations of the Image Decomposition Problem [18] as a Multicut Problem (MP) w.r.t. a superpixel graph have received considerable attention. In contrast, instances of the MP w.r.t. a pixel grid graph have received little attention, firstly, because the MP is NP-hard and instances w.r.t. a pixel grid graph are hard to solve in practice, and, secondly, due to the lack of long-range terms in the objective function of the MP. We propose a generalization of the MP with long-range terms (LMP). We design and implement two efficient algorithms (primal feasible heuristics) for the MP and LMP which allow us to study instances of both problems w.r.t. the pixel grid graphs of the images in the BSDS-500 benchmark. The decompositions we obtain do not differ significantly from the state of the art, suggesting that the LMP is a competitive formulation of the Image Decomposition Problem. To demonstrate the generality of the LMP, we apply it also to the Mesh Decomposition Problem posed by the Princeton benchmark [16], obtaining state-of-the-art decompositions.
P3‐143: UTILITY OF GENOMIC SEQUENCING IN CASES OF EARLY‐ONSET AND FAMILIAL DEMENTIA (2019)

One holdout in the rise of clinical genomic sequencing has been the realm of adult-onset neurological conditions. Possible reasons include phenotypic specificity and the availability of disease-specific gene panels. In this study, we seek to demonstrate the utility of whole genome sequencing in cases of early-onset and/or familial dementia. Participants were selected from a population of patients seen in the Memory Disorders Clinic at UAB. Whole genome sequencing was performed at 30X depth, and data was analyzed at HudsonAlpha. Samples from 16 participants were tested for C9orf72repeat expansion alleles. Prior clinical diagnoses for participants included Alzheimer's disease, frontotemporal dementia, and other unspecified dementia. Average age of onset was 54, and average age at enrollment was 59. 40.6% of participants had a strong family history of dementia, while 43.8% had some family history, and 15.6% had no reported family history of dementia. Out of 32 probands, we identified a likely explanation for symptoms in 15 (47%), with 9 cases meeting ACMG criteria of a dominant pathogenic or likely pathogenic variant (28%). We identified 5 individuals with pathogenic sequencing variants in Mendelian dementia-associated genes (APP& MAPT) and 3 individuals with pathogenic C9orf72repeat expansions (>145 G4C2repeats). In 2 cases, likely diagnoses were found that would not have been included on disease-specific panels (CSF1R, NOTCH3). Five participants were homozygous for the ε4 allele in APOE. Four individuals had variants of uncertain significance in a Mendelian dementia-associated gene (APP, PSEN1, MAPT). In 7 cases, risk-increasing alleles with an odds ratio of >2 were identified (PLD3, SORL1, ABCA7, AKAP9, TREM2).Eight participants were heterozygous for the ε4 APOEallele. Nine out of 32 participants (28%) had no returnable findings. This study demonstrates the utility of genomic sequencing in cases of dementia with suspicion of genetic etiology. Genomic sequencing casts a wider net and is able to identify genetic diagnoses in conditions with high genetic heterogeneity, nonspecific phenotypes, or established risk factors that do not follow a Mendelian pattern.
Convolutions for Spatial Interaction Modeling (2021)

In many different fields interactions between objects play a critical role in determining their behavior. Graph neural networks (GNNs) have emerged as a powerful tool for modeling interactions, although often at the cost of adding considerable complexity and latency. In this paper, we consider the problem of spatial interaction modeling in the context of predicting the motion of actors around autonomous vehicles, and investigate alternatives to GNNs. We revisit 2D convolutions and show that they can demonstrate comparable performance to graph networks in modeling spatial interactions with lower latency, thus providing an effective and efficient alternative in time-critical systems. Moreover, we propose a novel interaction loss to further improve the interaction modeling of the considered methods.
Evaluation of SmartStax and SmartStax PRO maize against western corn rootworm and northern corn rootworm: efficacy and resistance management (2017)

The addition of DvSnf7 in SmartStax PRO can reduce root damage under high WCR densities and prolong Cry3Bb1 and Cry34Ab1/Cry35Ab1 durability. © 2017 Society of Chemical Industry.
CMOS Active-Pixel Image Sensor With Intensity-Driven Readout (1996)

Proposed complementary metal oxide/semiconductor (CMOS) integrated-circuit image sensor automatically provides readouts from pixels in order of decreasing illumination intensity. Sensor operated in integration mode. Particularly useful in number of image-sensing tasks, including diffractive laser range-finding, three-dimensional imaging, event-driven readout of sparse sensor arrays, and star tracking.
Supersingular Curves With Small Non-integer Endomorphisms (2019)

We introduce a special class of supersingular curves over $\mathbb{F}_{p^2}$, characterized by the existence of non-integer endomorphisms of small degree. A number of properties of this set is proved. Most notably, we show that when this set partitions into subsets in such a way that curves within each subset have small-degree isogenies between them, but curves in distinct subsets have no small-degree isogenies between them. Despite this, we show that isogenies between these curves can be computed efficiently, giving a technique for computing isogenies between certain prescribed curves that cannot be reasonably connected by searching on $\ell$-isogeny graphs.
Phase I study of anti fibronectin 131I-L19-small immunoprotein (SIP): Preliminary dosimetric, pharmacokinetics (PK) and therapeutic results (2007)

947 AIM: L19-SIP is a human recombinant antibody fragment designed for tumor-targeted radioimmunotherapy (RIT). It was constructed using the variable regions of the L19 mAb directed against the Extra Domain B (ED-B) of fibronectin. ED-B is a glycoprotein of the subendothelial extracellular matrix of newly formed blood vessels in tumors and in tissues undergoing extensive remodeling (wound healing, chronic inflammatory disease). Primary objective: dosimetric evaluation of 131I-L19-SIP as a possible RIT for solid cancers. Secondary objectives: toxicity, PK and therapeutic efficacy evaluation. METHODS: Patients (pts) with progressive solid tumors of at least one lesion ≥ 2.5 cm underwent dosimetric and PK evaluation after iv administration of 87-193 MBq of 131I-L19-SIP. After 14-35 days, pts with a lesion/red marrow absorbed dose ratio ≥ 10 received a therapeutic dose of approx. 3700 MBq of 131I-L19-SIP. Dosimetric evaluation was conducted on double head whole body multi-static scans. The red marrow dose was evaluated assuming a fixed red marrow to blood concentration ratio of 0.19/(1 - hematocrit), typical for antibodies which initially distribute in a volume of 2.5-4 L. CT scans are performed at baseline and 4 weeks post therapeutic dose. Pts are followed for toxicity for at least 4 weeks after the therapeutic dose . RESULTS: So far 9 pts (7M/2F, median age 54 [range 38-74yrs] median ECOG PS 0 [range 0-1]) entered the dosimetric phase with the following tumors : colorectal (3), adrenocortical (1), renal cell (1), breast (1), NSCLC and urothelial (1) carcinomas, melanoma (2). The median number of prior chemotherapies for advanced disease was 3 (range 1-3). To date 5 pts have received the therapeutic dose. The median Vd 6.56 L is larger than expected, likely due to the molecular size of L19-SIP, smaller than that of a full size antibody. Median blood t1/2 is 38.2 h. The median absorbed doses are (Gy): heart wall 2.41, kidneys 3.74, liver 3.68, lungs 2.24, testes 3.69, red marrow 0.69, therapeutic-phase patient tumors 8.5. Grade 3/4 drug-related toxicity post therapeutic dose was limited to one severely malnourished patient, who developed grade 4 thrombocytopenia. No other hematological toxicity was noted. Though no objective tumor response was observed, clinical benefit was seen in 2 pts. A significant, durable reduction in daily morphine intake was reported in a breast cancer patient with a brachial plexus neoplastic infiltration. Cutaneous disease stabilization was observed in a melanoma patient with daily appearance of cutaneous lesions. CONCLUSION: Unexpectedly low red marrow specific absorbed dose, absence of toxicities, and a high tumor uptake, suggests to safely increase the therapeutic administered activity of 131I-L19-SIP to further characterize toxicity and efficacy. Study sponsored by PHILOGEN SpA, Siena (Italy) and supported by Schering AG, Berlin (Germany).