gebhart/patrepeval huggingface dataset:
AMT Control for a Mild-Hybrid Urban Vehicle with a Downsized Turbo-Charged CNG Engine (2007)

&lt;div class="htmlview paragraph"&gt;Compressed natural gas (CNG) is considered as one of the most promising alternative fuels for transportation due to its ability to reduce greenhouse gas emissions (CO&lt;sub&gt;2&lt;/sub&gt;, in particular) and its abundance. An earlier study from IFP has shown that CNG has a considerable potential when used as a fuel for a dedicated downsized turbo-charged SI engine on a small urban vehicle. To take further advantage of CNG assets, this approach can be profitably extended by adding a small secondary (electrical) power source to the CNG engine, thus hybridizing the powertrain. This is precisely the focus of the new IFP project, VEHGAN, which aims to develop a mild-hybrid CNG prototype vehicle based on a MCC smart car equipped with a reversible starter-alternator and ultra-capacitors (Valeo Starter Alternator Reversible System, StARS). The unfolding of this project has involved and will involve several interesting and challenging issues from an engine control point of view, such as mastering the automatic manual transmission (AMT) control system and integrating a new power source, with its new functions, into the torque-oriented engine control structure.&lt;/div&gt;
High-content assays for evaluating cellular and hepatic diacylglycerol acyltransferase activity (2010)

Acyl-CoA:diacylglycerol acyltransferase (DGAT) catalyzes the terminal step in triglyceride (TG) synthesis using diacylglycerol (DAG) and fatty acyl-CoA as substrates. In the liver, the production of VLDL permits the delivery of hydrophobic TG from the liver to peripheral tissues for energy metabolism. We describe here a novel high-content, high-throughput LC/MS/MS-based cellular assay for determining DGAT activity. We treated endogenous DGAT-expressing cells with stable isotope-labeled [¹³C₁₈]oleic acid. The [¹³C₁₈]oleoyl-incorporated TG and DAG lipid species were profiled. The TG synthesis pathway assay was optimized to a one-step extraction, followed by LC/MS/MS quantification. Further, we report a novel LC/MS/MS method for tracing hepatic TG synthesis and VLDL-TG secretion in vivo by administering [¹³C₁₈]oleic acid to rats. The [¹³C₁₈]oleic acid-incorporated VLDL-TG was detected after one-step extraction without conventional separation of TG and recovery by derivatizing [¹³C₁₈]oleic acid for detection. Using potent and selective DGAT1 inhibitors as pharmacological tools, we measured changes in [¹³C₁₈]oleoyl-incorporated TG and DAG and demonstrated that DGAT1 inhibition significantly reduced [¹³C₁₈]oleoyl-incorporated VLDL-TG. This DGAT1-selective assay will enable researchers to discern differences between the roles of DGAT1 and DGAT2 in TG synthesis in vitro and in vivo.
Assessment of Nanotechnology for Chemical Biological Defense (2009)

Nanotechnology encompasses a broad and rapidly growing set of projects in basic research, applied research, early attempts at commercialization, and even mature technologies. A multidisciplinary team from the Massachusetts Institute of Technology Lincoln Laboratory (MIT-LL) and the U.S. Army Natick Soldier Research, Development, and Engineering Center (NSRDEC) was tasked by the Special Projects Office at the Joint Science and Technology Office for Chemical and Biological Defense (JSTO-CBD) to assess ongoing nanotechnology research efforts and commercial off-the-shelf nanotechnologies relevant to CBD, with particular emphasis on projected needs and technology gaps in the Protection, Detection, Decontamination, and Medical CBD capability areas. This broad-based assessment resulted in a list of recommended technologies to address these needs. This paper addresses the process utilized for the assessment and provides the technical detail for the recommended technologies. Early access to advanced CBD capabilities based on the unique properties of nanotechnology has high potential to provide significantly better performance than incremental improvements in current technology.
FIGURE 3 from A Very Long-acting Exatecan and Its Synergism with DNA Damage Response Inhibitors (2023)

&lt;p&gt;Treatment of MX-1 xenografts (N-6/group) with single doses of PEG-Exa 3A and PLX038A. &lt;b&gt;A,&lt;/b&gt; Median relative tumor volume ± interquartile range versus t. The starting tumor volume for all groups was 129 ± 38 mm&lt;sup&gt;3&lt;/sup&gt;. &lt;i&gt;P&lt;/i&gt; values at 21 days from one-way ANOVA analysis versus vehicle were: 0.008 (PLX038A), 0.01 (2.5 μmol/kg PEG-Exa), 0.0002 (5 μmol/kg PEG-Exa), &lt;0.0001 (10 and 15 μmol/kg PEG-Exa). &lt;b&gt;B,&lt;/b&gt; Median relative body weight of mice over time. Mice (&lt;i&gt;N&lt;/i&gt; = 6 per group) received a single intraperitoneal dose of vehicle (●), PEG-Exa at 15 μmol/kg (■), 10 μmol/kg (▲), 5 μmol/kg (▼), 2.5 μmol/kg (◆), or PLX038A at 15 μmol/kg (○).&lt;/p&gt;
Rationale and Methodology for a Community-Based Study of Diabetic Retinopathy in an Indonesian Population with Type 2 Diabetes Mellitus: The Jogjakarta Eye Diabetic Study in the Community (2016)

JOGED.COM is the first epidemiologic study of DR in an Indonesian population. This study will provide key information about the prevalence and risk factors of DR in the community. These data are very important for future health promotion programs to reduce the burden of DR in the population.
Dynamic Caching Content Replacement in Base Station Assisted Wireless D2D Caching Networks (2020)

The concentrated popularity distribution of video files and the caching of popular files on users and their subsequent distribution via device-to-device (D2D) communications have dramatically increased the throughput of wireless video networks. However, since popularity distribution is not time-invariant, and the files available in the neighborhood can change when other users move into and out of the neighborhood, there is a need for replacement of cache content. In this work, we propose a practical and feasible replacement architecture for base station (BS) assisted wireless D2D caching networks by exploiting the broadcasting of the BS. Based on the proposed architecture, we formulate a caching content replacement problem, with the goal of maximizing the time-average service rate under the cost constraint and queue stability. We combine the reward-to-go concept and the drift-plus-penalty methodology to develop a solution framework for the problem at hand. To realize the solution framework, two algorithms are proposed. The first algorithm is simple, but exploits only the historical record. The second algorithm can exploit both the historical record and future information, but is complex. Our simulation results indicate that when dynamics exist, the systems exploiting the proposed designs can outperform the systems using a static policy.
Highly Reliable MEMS Temperature Sensors for 275 $^{ \circ}\hbox{C}$ Applications—Part 2: Creep and Cycling Performance (2012)

The second part of this paper presents an experimental reliability assessment of microelectromechanical-system bimorph cantilever beams for high-temperature sensing applications. The sensor, presented in Part I, is shown to operate up to 275 °C and to have a quality factor of over 5000 at room temperature, a response time of under 600 μ s, and an inherent capacitance uncertainty of under 0.13 fF. In this part, the reliability of the bimorph component of the sensor is tested at sustained high temperatures (up to 275 °C), as well as throughout thermal cycling. The cantilevers are initially thermally annealed to relax the film stresses. During the anneal of the device, there is a decrease in room-temperature tip displacement from 120 to 70 μm and a decrease in the high-temperature tip displacement from 40 to 10 μm. After the thermal anneal, the devices show less than 3 μm of further creep after three months (over 2000 h) at 200 °C and over 120 h at 275 °C. Over 20 samples have been successfully tested up to 100 million cycles without failure. Record results are demonstrated to over 1.2 billion thermal cycles from fully relaxed to fully deflected states. Consisting of over 1000 beam profile measurements and dozens of individual fabricated chips, this represents one of the largest reliability studies of bimorphs to date.
Integrated heterogeneous silicon/III–V mode-locked lasers (2018)

The mode-locked laser diode has emerged as a promising candidate as a signal source for photonic radar systems, wireless data transmission, and frequency comb spectroscopy. They have the advantages of small size, low cost, high reliability, and low power consumption, thanks to semiconductor technology. Mode-locked lasers based on silicon photonics advance these qualities by the use of highly advanced silicon manufacturing technology. This paper will begin by giving an overview of mode-locked laser diode literature, and then focus on mode-locked lasers on silicon. The dependence of mode-locked laser performance on design details is presented.
A New Approach to the Synthesis of Phenol-Containing Macroheterocycles (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA New Approach to the Synthesis of Phenol-Containing MacroheterocyclesAndrei V. Bordunov, Nikolai G. Lukyanenko, Victor N. Pastushok, Krzysztof E. Krakowiak, Jerald S. Bradshaw, N. Kent Dalley, and Xiaolan KouCite this: J. Org. Chem. 1995, 60, 15, 4912–4918Publication Date (Print):July 1, 1995Publication History Published online1 May 2002Published inissue 1 July 1995https://doi.org/10.1021/jo00120a040RIGHTS & PERMISSIONSArticle Views317Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (833 KB) Get e-Alerts Get e-Alerts
Transmural perfusion gradient analysis by high-resolution MR versus fractional flow reserve for the assessment of coronary artery stenosis (2012)

We present the results of transmural perfusion gradient (TPG) analysis (a novel method to evaluate the presence of subendocardial ischemia) versus fractional flow reserve (FFR) for the detection of hemodynamically significant coronary artery disease (CAD).
Comparison of SUVmax quantitation between OSEM and BSREM (regularized iterative) reconstruction when combined with a data-driven PET quiescent period gating (DDQPG) (2015)

562 Objectives The objective of this study was to compare PET quantitation change between two iterative reconstruction approaches when combined with a quiescent period gating. The regularized reconstruction method is hypothesized to benefit more (as compared to OSEM) from reduction in motion blur for tracer-avid features. Methods Data from nine FDG PET/CT cases were used. Fourteen tracer-avid features were identified for comparison. The quiescent period gating used triggers determined from the PET listmode data using a PCA-based analysis (DDG). The gating kept 50% of the data between phases [30,80]% from end-inspiration. Image reconstruction was performed with (50% duration) OSEM and BSREM, then using each method combined with DDQPG. By using shorter duration, non-gated scans, the noise properties of the non-gated and gated results were expected to be the same. Tracer-avid feature SUVmax was compared between the four approaches. Results In general, the SUVmax increased with application of DDQPG as compared to the time-matched standard reconstruction. The average magnitude change in SUVmax with OSEM and OSEM+DDQPG was (12.2% ± 12.3%) while with regularized reconstruction it was (17.6% ± 19.4%). The average overall change in SUVmax (comparing without/with DDQPG within a reconstruction technique) was (11.5%, 15.2%) with OSEM and BSREM, respectively. Comparing only the non-gated results, the average increase in SUVmax was 11.4% when using BSREM. A plot showing all results is included in the attached figure. At least two of the features in the spine were not expected to move with respiration. Conclusions Application of DDQPG increased SUVmax for both reconstruction methods. Use of BSREM increased SUVmax both without and with DDQPG. BSREM reconstruction coupled with DDQPG produced slightly higher SUVmax on average as compared to standard OSEM coupled with DDQPG. Data collection is ongoing to extend this analysis.
Packet Inter-Reception Time Modeling for High-Density Platooning in Varying Surrounding Traffic Density (2019)

A recent feature of communications systems is the agile quality of service adaptation, in which the application and the communications system exchange requirements and prediction of quality of service. The application first provides its quality of service requirement. The communications system tries to enforce it, and makes a prediction of the available quality of service. Finally, the application adapts its settings to the future quality of service and provides updated requirements. Though this concept is originally designed for cellular-based technologies, it is also applicable to ad-hoc communication systems. In this paper, we focus on the prediction of quality of service for ad-hoc communications in a high-density platooning system. The quality of service of interest is the packet inter-reception time in an IEEE 802.11p network. Our platooning system drives through different vehicular traffic conditions, in which we gather transmission and position data. We then analyze the distribution of the packet inter-reception time to select the model features and then fit multiple distribution models. This empirical prediction modeling will then be the baseline for future modeling.
Multiple Harmonics Analysis for Variable Frequency Variable Duty-Cycle Controlled Inductive Power Transfer Systems (2018)

Variable frequency variable duty-cycle (VFVDC) control is a widely adopted control scheme in inductive power transfer (IPT). One characteristic of variable frequency variable duty-cycle controlled IPT systems is that they could contain multiple harmonics. Conventional first harmonics approximation (FHA) analysis method only considers the fundamental harmonic signals. Hence, a new analytical technique is needed. In this paper, a new analytical technique called multiple harmonics analysis (MHA) is developed to analyze IPT systems operating at variable frequency and variable duty-cycle mode. The MHA technique can predict behaviors of harmonics and give insights into IPT systems. It is also shown that MHA is more accurate than FHA by both calculation and measurements.
Evaluation Of Patients With Myelodysplastic Syndrome (MDS) Up To Age Seventy-Five, Referred For Allogeneic Hematopoietic Cell Transplant (HCT) Including Donor Availability And HCT Outcomes (2010)

Allogeneic HCT remains the only curative treatment strategy for patients (pts) with MDS. Moffitt Cancer Center (MCC) has implemented a targeted IV busulfan plus fludarabine (tBuFlu) induction regimen that is myeloablative, with reduced treatment related toxicity, permitting the expansion of empiric age limitations for HCT up to 75 years (yrs). From January 2004 on, 243 new pts (NP) with a diagnosis of MDS or CMML were evaluated for HCT. An allogeneic donor was identified in 170 pts and 112 received an HCT. The median age of the 112 transplant pts was 55.6 yrs (24.8 – 73.5). Sixty pts were older than 55 yrs. At the NP visit, IPSS risk was Low (11), Int-1 (35), Int-2 (42), and High (21) or not evaluable (3) (NE). Donors included 49 sibling donors (SIB), 48 matched unrelated donors (MUD) and 15 mismatched unrelated donors (mMUD). Median follow-up is 19.3 months (0 – 61.4) and the Kaplan-Meier overall survival (OS) from NP visit is 77% at one year and 56% at two years. Overall survival is not statistically different between SIB, MUD or mMUD HCT (P=0.39). In 58 pts who did not receive a HCT, a donor was identified. (Yes donor, No HCT) Median age was 57 yrs (19 – 69) with 28 pts older than 55yrs. At the NP visit, IPSS was Low (5), Int-1 (19), Int-2 (17), High (16) and NE (1). Donors included SIB (14), MUD (27), mMUD (15), and umbilical cord blood (2). Median follow up is 10.3 months (1.7 – 66.3). Seventy-three pts did not obtain a donor (No Donor, No HCT). Median age was 64.4 yrs (32.6 – 72.1) with 65 pts older than 55yrs. IPSS at NP visit was Low (8), Int-1 (16), Int-2 (25), High (16) and NE (8). Median follow up of these pts is 6.7 months (0.9 – 61.3). For the entire cohort (243 pts), pts with a donor had significantly improved overall survival vs pts with no donor (P=0.003); there was no difference in OS between pts with a donor who did not proceed to HCT and everyone without a donor (P=0.27). Twenty-eight of the 73 pts without a donor did not have donor searches. If these are excluded, in the remaining 215pts OS for pts with an identified donor was improved compared to OS of those without a donor (P=0.009) and pts with a donor and no HCT had similar OS to those without an identified donor (P=0.3). These data demonstrate that 70% of patients can acquire a suitable allogeneic donor and 47% of patients seen as a HCT new patient consult can proceed to HCT for MDS with a significant overall survival advantage using a SIB, MUD or mMUD.
Aerodynamic shape optimization of rotary wing aircraft components using advanced multiobjective evolutionary algorithms (2012)

The aim of this Doctoral Thesis, sponsored by AgustaWestland, is the design and development of a multi-objective optimization procedure that involves the application of the GeDEA-II, a powerful and time-saving evolutionary algorithm recently developed by the author at the University of Padova, able to perform multi-objective optimization analyses with the general approach of the Pareto frontier search. When compared to other state-of-the-art multi-objective evolutionary algorithms, it features novel crossover and mutation operators, and demonstrated superior performance.
This optimizer supervises an automatic optimization loop involving the CFD commercial and free, open source solvers, respectively Fluent® and OpenFOAM®.
Altair Hyperworks package is chosen as the free-form-deformation parameterization engine.
The test cases chosen to demonstrate the strength of the procedure implemented concern the aerodynamic optimization of the AgustaWestland ERICA nose region, and the optimization of the intake 1 of the AW101 helicopter, that is really challenging problems from both the engineering and the industrial point of view.
Starting from the the geometry elaboration and proceeding to the results discussion, each step of the optimization procedure is described in details, with particular focus on the automatic optimization loop, directly programmed by the author in both UNIX/Linux and Windows environments.
The results obtained surely demonstrate the effectiveness of the multiobjective approach chosen to carry out this work.
Furthermore, some suggestions for future improvements and developments are provided, with the purpose to increase the strength of the discussed multi-objective optimization tool.
Critical Current and AC Loss of&lt;tex&gt;$rm Bi_2rm Sr_2rm Ca_2rm Cu_3rm O_10/rm Ag$&lt;/tex&gt;Tapes Subjected to Tensile Stress (2005)

Practical applications of HTS tapes cannot avoid various stresses and strains, including tension, bending and/or torsion. These loads directly affect the critical current and AC losses of HTS tapes. Thus the investigation of the effect of stress/strain on HTS tapes is important for practical applications. Here, the critical currents and AC losses are measured at 77 K for different Bi2223/Ag composite tapes under different room temperature stress/strain. The strain dependence of the critical currents and AC losses of Bi2223/Ag composite superconducting tapes are studied. A comparison is given for the measured results and the values calculated from the formulae developed from the Norris formula and critical current-strain relationship.
High-Speed Serial Optical Link Test Bench Using FPGA with Embedded Transceivers (2009)

We develop a custom Bit Error Rate test bench based on Altera's Stratix II GX transceiver signal integrity development kit, demonstrate it on point-to-point serial optical link with data rate up to 5 Gbps, and compare it with commercial stand alone tester. The 8B/10B protocol is implemented and its effects studied. A variable optical attenuator is inserted in the fibre loop to induce transmission degradation and to measure receiver sensitivity. We report comparable receiver sensitivity results using the FPGA based tester and commercial tester. The results of the FPGA also shows that there are more one-to-zero bit flips than zero-to-one bit flips at lower error rate. In 8B/10B coded transmission, there are more word errors than bit flips, and the total error rate is less than two times that of non-coded transmission. Total error rate measured complies with simulation results, according to the protocol setup.
Learning sparse multiple cause models (2002)

Multiple cause models (MCM) are a way to describe patterns as a superposition of a selection of cause patterns. In contrast to clustering methods and dimensionality reduction, multiple cause models are capable of turning local features on and off and this makes them a more realistic model for many types of data. However, inference and learning in general multiple cause models takes an amount of time that is exponential in the number of causes. We present an approximate inference algorithm that examines only sparse cause patterns, i.e., those configurations of causes where only a small number of causes are active at a time. This leads to an approximate EM algorithm that maximizes a lower bound on the likelihood of a data set. We show that this sparse multiple cause model can model different types of human facial expression patterns. Performance comparison of the MCM classifier with the SNoW (sparse network of winnows) architecture and the nearest neighbor classifier reveals significant improvement in classification accuracy using the MCM classifier.
Outcomes of pathologically localized high-grade prostate cancer treated with radical prostatectomy (2019)

Adjuvant radiation therapy (ART) is recommended without consideration of radical prostatectomy Gleason score (RP GS) for cases with adverse features. We compared the outcomes of pathologically localized high-grade (GS 8-10) prostate cancer (PC) with those of pT3 GS 7 PC.A total of 1585 men who underwent RP between 1995 and 2015 comprised the cohort, which was divided into group 1 (RP GS 7(3 + 4) and pT3; n = 760), group 2 (RP GS 7(4 + 3) and pT3; n = 565), and group 3 (RP GS 8-10 and pT2; n = 260). Biochemical recurrence (BCR), all-cause mortality (ACM), and PC-specific mortality (PCSM) risk were compared among groups using Cox regression and competing risk analysis.At a median follow-up of 58 months (interquartile range: 37-85), 721 men experienced BCR and 84 died (22 due to PC). BCR-free survival rates were lower in group 3 than in group 1 (P < .001); nevertheless, no difference was observed between groups 2 and 3 (P = .638). Furthermore, no difference in ACM was noted among groups. PCSM rates were higher in group 3 than in groups 1 and 2 (P = .001 and P = .005, respectively). This association persisted in multivariate models after adjustment for clinicopathological variables.Patients with RP GS 8-10 and pT2 PC had higher BCR and PCSM rates than those with RP GS 7 and pT3 PC. Localized high-grade PC should be considered in decision-making for ART.