gebhart/patrepeval huggingface dataset:
IL-33 Is a Negative Regulator of Vaccine-Induced Antigen-Specific Cellular Immunity (2019)

The cytokine IL-33 is a well-established inducer of Th2 responses. However, roles for IL-33 in promoting CD8, Th1, and T regulatory cell responses have also emerged. In this study, the role of IL-33 as a regulator of particulate vaccine adjuvant-induced Ag-specific cellular immunity was investigated. We found that polymeric nanoparticles surpassed alum in their ability to enhance Ag-specific CD8 and Th1 responses. IL-33 was a potent negative regulator of both CD8<sup>+</sup> T cell and Th1 responses following i.m. vaccination with Ag and nanoparticles, whereas the cytokine was required for the nanoparticle enhancement in Ag-specific IL-10. In contrast to the effect on cellular immunity, Ab responses were comparable between vaccinated wild-type and IL-33-deficient mice. IL-33 did not compromise alum-induced adaptive cellular immunity after i.m. vaccination. These data suggest that IL-33 attenuates the induction of cellular immune responses by nanoparticulate adjuvants and should be considered in the rational design of vaccines targeting enhanced CD8 and Th1 responses.
Role of uric acid in different types of calcium oxalate renal calculi (2006)

From these results it can be deduced that uric acid can play an important role as inducer (heterogeneous nucleant) of COM unattached calculi with the core formed by uric acid identifiable by SEM coupled to X-ray microanalysis (these calculi constitute the 1.2% of all calculi) and in COM unattached calculi with the core mainly formed by COM crystals and organic matter (these calculi constitute the 10.8% of all calculi).
Clinical Instructors' Perceptions of Critical Knowledge, Critical Patient Care Skills, and Student Physical Therapist Preparedness in the Acute Care Setting. (2019)

The results of this study reveal gaps in preparedness that are important areas for academic and clinical emphasis to support student success in the acute care setting.
Selective activity of several cholic acid derivatives against human immunodeficiency virus replication in vitro. (1989)

Several cholic acid derivatives such as taurolithocholic acid, lithocholic acid 3-sulfate, taurolithocholic acid 3-sulfate, and glycolithocholic acid 3-sulfate were shown to inhibit selectively the replication of human immunodeficiency virus type 1 (HIV-1) in vitro. These compounds completely protected MT-4 cells against HIV-1-induced cytopathogenicity at a concentration of 100 micrograms/ml, whereas no toxicity for the host cells was observed at 200 micrograms/ml. They also inhibited HIV-1 antigen expression in HIV-1-infected CEM cells. The bile acids (cholic acid, deoxycholic acid, chenodeoxycholic acid, and lithocholic acid) did not show any inhibitory effect on HIV-1 replication at concentrations that were not toxic to the host (MT-4) cells. From a structure-function analysis of a number of cholic acid derivatives, the presence of either a sulfonate (as in the tauro conjugates) or a sulfate group as well as the "litho" configuration appeared to be necessary for the expression of anti-HIV-1 activity. The active cholic acid derivatives did not directly inactivate the virus particles at the concentrations that were not toxic to the host cells. Lithocholic acid 3-sulfate, taurolithocholic acid 3-sulfate, and glycolithocholic acid 3-sulfate, but not taurolithocholic acid, partially inhibited virus adsorption to MT-4 cells. These three compounds were also inhibitory to the reverse transcriptase activity associated with HIV-1.
Humoral modulation of human acute myelogenous leukemia cell growth in vitro. (1980)

Two human acute myelogenous leukemia cell lines have been established: KG-1 and HL-60. Both lines retain the characteristics of myeloid cells. We have used these lines as models to study the humoral modulation of human leukemic cell proliferation. The leukemic cells were grown in liquid culture and then subcultured in agar. Agents were added directly to the agar plates, and colonies were enumerated after incubation for 2 weeks. The KG-1 clonal cells were markedly stimulated by colony-stimulating factor; HL-60 cells also responded but less dramatically. Prostaglandins E2 and E1 inhibited leukemic colony-forming cells. At 10-6 and 10-7 m, prostaglandins E2 and E1 inhibited colony formation by 60 and 28%, respectively. No inhibitory activity was noted with prostaglandin F2α, N 6, O 2′-dibutyryl cyclic adenosine 3′:5′-monophosphate inhibited KG-1 colony formation 41% at a concentration of 10-5 m. Theophylline, epinephrine, and other agents known to increase cellular cyclic adenosine 3′:5′-monophosphate inhibited leukemic colony-forming cells at 10-4 to 10-6 m. Dibutyryl cyclic guanosine 3′:5′-monophosphate and agents that increase intracellular cyclic guanosine 3′:5′-monophosphate were not inhibitory.

Estradiol, thyroxine, and the polypeptide hormones, insulin and growth hormone, had no effect on leukemic colony formation. These results show that human myeloid leukemia cell growth can be humorally modulated in vitro , and responsiveness is qualitatively similar to that observed for normal myeloid progenitors.
De la souris à l’homme et de la paillasse (du laboratoire) au lit du maladeFrom mice to men and bench to bed (2012)

L’exposé ci-dessous présente les quelques lignes de force qui ont structuré les réflexions et les débats du colloque. Une première question est celle des modèles animaux. Ceux-ci fournissent une source irremplaçable de connaissances immunologiques, mais manquent de prédictibilité pour ce qui concerne leur exploitation médicale pour l’homme. L’étude du poisson-zèbre, de la lamproie, des oiseaux et surtout de la souris est formidablement instructive. Le biologiste éprouve un véritable émerveill...
Pathological changes in cynomolgus monkeys after laser-photocoagulation. (2015)

&lt;p&gt;LGN: lateral geniculate layer, ONH: optic nerve head, ON: optic nerve, GFAP: glial fibrillary acidic protein, Iba-1: ionized calcium-binding adaptermolecule-1, PBR: peripheral benzodiazepine receptor. Glaucoma stages were classified by histological changes based on the extent of axonal loss as mild (0–20%), moderate (20–50%), and advanced glaucoma (50–100%). Neuronal atrophy, RGC loss and immunoreactivity were classified based on the quantitative data as follows: no changes; −, mild; +, moderate; ++, robust; +++.&lt;/p&gt;
Power reduction by adaptively optimizing optical power using actual BER for 10G-EPON systems (2013)

The OLT calculates the pre-FEC BER using the number of corrected error bits, and decides the optical power of the ONU transmitter. The ONU adaptively adjusts the optical power according to the decision during the discovery window. The power consumption is reduced by 250 mW without any additional devices and without degrading throughput.
Nickel-loaded La2Ti2O7 as a bifunctional photocatalyst (2002)

Nickel-loaded La2Ti2O7, one of the highly donor-doped (110) layered perovskite materials, has been found to be an efficient photocatalyst for simultaneous H2 production from water splitting and decomposition of tetramethylammonium hydroxide (TMAH) under UV irradiation.
Carrier Frequency Estimation of MPSK Modulated Signals (1999)

In this paper we concentrate on MPSK carrier frequency estmation based on random data modulation. We present a fast, open-loop frequency estimation and tracking techinque, which combines a feedforward estimator stucture and a recursive least square (RLS) predictor. It is suitable for the frequency estimation and large frequency acquisition and tracking required of burst mode satellite modems operating under the condition of low SNR and large burst-to-burst frequency o#set. The performance of the estimator is analyzed in detail and simulation results are shown. Finally, the non-linear impact of data modulation removal methods is discussed. The estimator we derived is easily implemented with digital hardware. 1 Y. Jiang: Carrier Frequency Estimation of MPSK Modulated Signals 2 1 Introduction Carrier frequency recovery is very important to MPSK modems. Fast frequency estimation and tracking is necessary for burst mode satellite modems operating in the presence of large frequency...
ChemInform Abstract: Bioactive Amino Acids, Peptides and Peptidomimetics Containing Silicon (2015)

Abstract Review: 83 refs.
Determination of Chemical Shift Anisotropy Tensors of Carbonyl Nuclei in Proteins through Cross‐Correlated Relaxation in NMR (2004)

The principal components and orientations of the chemical shift anisotropy (CSA) tensors of nearly all 13C carbonyl nuclei in a small protein have been determined in isotropic solution by a combination of three complementary cross-correlation measurements.
Integrated-optical modulators for bandpass analog links (1991)

Integrated-optical interferometric modulators specifically designed and demonstrated for bandpass analog optical systems are described. Techniques such as nondissipative impedance matching for lumped-element modulators and electrooptic phase reversal for traveling-wave devices can provide substantially higher modulator response than conventional baseband designs. Recent results on the use of the polarization-mixing technique to improve modulator linearity at microwave frequencies are also discussed.
Spectral Representations of Nonmodal Phonation (2007)

Regions of nonmodal phonation, which exhibit deviations from uniform glottal-pulse periods and amplitudes, occur often in speech and convey information about linguistic content, speaker identity, and vocal health. Some aspects of these deviations are random, including small perturbations, known as jitter and shimmer, as well as more significant aperiodicities. Other aspects are deterministic, including repeating patterns of fluctuations such as diplophonia and triplophonia. These deviations are often the source of misinterpretation of the spectrum. In this paper, we introduce a general signal-processing framework for interpreting the effects of both stochastic and deterministic aspects of nonmodality on the short-time spectrum. As an example, we show that the spectrum is sensitive to even small perturbations in the timing and amplitudes of glottal pulses. In addition, we illustrate important characteristics that can arise in the spectrum, including apparent shifting of the harmonics and the appearance of multiple pitches. For stochastic perturbations, we arrive at a formulation of the power-spectral density as the sum of a low-pass line spectrum and a high-pass noise floor. Our findings are relevant to a number of speech-processing areas including linear-prediction analysis, sinusoidal analysis-synthesis, spectrally derived features, and the analysis of disordered voices.
The Wireless Seat Belt Requirements, Experiments, and Solutions for Pedestrian Safety (2018)

The World Health organization in its latest report on road safety states that 22% of all road traffic deaths comprise pedestrians, approximately 275,000 pedestrians worldwide. Based on an overview of typical accident scenarios, we argue how an ideal pedestrian safety system should look like. Then we investigate how much our approach of a pedestrian safety system, which we call “Wireless Seat Belt” (WSB), can satisfy the requirements of such an ideal system in terms of position accuracy. Next, we experimentally show what can be done with current smartphones in terms of these requirements. We show that current smartphone accuracy is not sufficient for reliable collision avoidance. To address this problem, we introduce and evaluate two approaches using context information to enable “off-the-shelf” smartphones to reach the required accuracy requirements.
Stereoselective organocascades: from fundamentals to recent developments (2021)

Abstract Reaction sequences where more bonds are sequentially formed (cascade reactions) may be started either by a stoichiometric or by a catalytic reagent, and proceed in an enantio- diastereo- or non-stereo- selective manner. A wide variety of such strategies has been developed, including both stoichiometric and catalytic ones. Within the widely developed cascade reactions field, this chapter is not meant to be omni-comprehensive, but to offer an as much as possible complete overview on organocatalytic stereoselective methods. We embrace the more general definitions by Tietze and Denmark, considering as cascade reactions all those one-pot processes that involve two or more bond formations, where each subsequent step is enabled by a structural change caused by the previous one. We will include both two- and multi-component reactions where one or more organocatalysts may be responsible either for all or just some of the occurring transformations. Organocascades will be reported according to the number of involved catalytic cycles. In the following paragraphs, only cascade reactions that are stereoselective by means of a chiral catalyst will be considered. It will be shown that multiple possibilities, relying on different catalysis modes, are available to achieve the same reaction sequence.
An advanced bimode insulated gate transistor BIGT with low diode conduction losses under a positive gate bias (2017)

Despite the previously reported benefits of High Voltage Reverse Conducting RC-IGBT concepts such as the BIGT, the main obstacle for adopting them in mainstream applications is the dependency of the diode conduction losses on the applied gate voltage polarity. In most applications, adaptations are required at both control and gate drive levels for providing lower diode conduction losses. The paper investigates this particular issue with respect to the device design. With the aid of both simulation and experimental results, an advanced low loss BIGT, which can operate efficiently under all gate bias conditions is proposed.
Proceedings of the 5th International Workshop on Trustworthy Embedded Devices (2015)

The 5th International Workshop on Trustworthy Embedded Devices (TrustED 2015) was held October 16th, 2015 in Denver, Colorado, USA, and has been co-located with the 22nd ACM Conference on Computer and Communications Security (CCS 2015). TrustED 2015 is a continuation of previous workshops in this series, which were held in conjunction with ESORICS 2011, IEEE Security & Privacy 2012, ACM CCS 2013, and ACM CCS 2014 (see http://www.trusted-workshop.de for details). The Internet of Things promises to make reality Mark Weisser's vision of ubiquitous computation set out in his 1991 influential paper. This vision has already started to become reality through modern technologies that allow for electronic systems to be embedded practically everywhere. Yet to make such vision successful, it is widely acknowledged that security of super large distributed systems has to be guaranteed and the privacy of the collected data protected. The Internet of Things, made possible through the wide deployment of embedded devices, differs significantly from "classical" systems, such as desktop (networked) PCs, in various aspects, which include: severe computational, memory, and power constraints, lack of advanced user interfaces, an increased vulnerability with respect to physical or network attacks, inability to provide strong hardware security guarantees, and as mentioned previously, their tendency to collect potentially highly privacy sensitive data. Given the above, major themes of TrustED 2015 include security and privacy aspects of the Internet of Things and in particular of embedded devices as parts of cyber physical systems and their environments. It aims to bring together experts from academia and research institutes, industry, and government in the field of security and privacy in cyber physical systems to discuss and investigate the problems, challenges, and recent scientific and technological developments in this field. This year, eleven papers have been submitted. Each paper received at least three reviews, which were followed by an online discussion to decide on the program. Papers co-authored by one PC chair were exclusively handled by the other. The program committee accepted six papers that cover a variety of topics, including Physical Unclonable Functions, side-channel attacks, hardware security, system security, and digital rights management in embedded platforms. In addition to the technical program, the workshop featured four internationally highly renowned speakers: Geremy Condra, Marten van Dijk, Jakub Szefer, and André Weimerskirch.
Antiviral treatment for hepatitisBvirus recurrence following liver transplantation (2013)

The purpose of this study was to identify the factors associated with the recurrence of hepatitis B virus (HBV) following liver transplantation (LT) for HBV-related disease and to recognize the outcome of treatment for HBV recurrence with oral nucleos(t)ide analogues. Six hundred and sixty-seven LTs were performed for HBsAg-positive adult patients in our institute from 1996 to 2010. HBV prophylaxis was performed by hepatitis B immunoglobulin (HBIG) monotherapy or HBIG and entecavir combination therapy. There were 63 cases (11.4%) of HBV recurrences during a median follow-up of 51 months. The median time to HBV recurrence was 22 months. A preoperative HBV DNA load of more than 10(5) IU/mL, HBIG monotherapy, and hepatocellular carcinoma in the explant liver were independent risk factors for HBV recurrence following LT in multivariate analysis. Patient survival at 10 yr was 54.2% for HBV-recurrent patients. Among patients with HBV recurrence, HBsAg seroclearance was achieved in 13 patients (20.6%), but HBsAg seroclearance did not affect survival in these patients after the recurrence of HBV (p = 0.28). The recurrence of HBV led to graft failure in six cases. HBV recurrence should be prevented by strict management of pre-transplant HBV viremia and an effective post-transplant HBV prophylaxis.
Performance of a multiple venturi fuel-air preparation system (1979)

Spatial fuel-air distributions, degree of vaporization, and pressure drop were measured 16.5 cm downstream of the fuel injection plane of a multiple Venturi tube fuel injector. Tests were performed in a 12 cm tubular duct. Test conditions were: a pressure of 0.3 MPa, inlet air temperature from 400 to 800K, air velocities of 10 and 20 m/s, and fuel-air ratios of 0.010 and 0.020. The fuel was Diesel #2. Spatial fuel-air distributions were within + or - 20 percent of the mean at inlet air temperatures above 450K. At an inlet air temperature of 400K, the fuel-air distribution was measured when a 50 percent blockage plate was placed 9.2 cm upstream of the fuel injection plane to distort the inlet air velocity fuel injection plane to distort the inlet air velocity profile. Vaporization of the fuel was 50 percent complete at an inlet air temperature of 400K and the percentage increased linearly with temperature to complete vaporization at 600K. The pressure drop was 3 percent at the design point which was three times greater than the designed value and the single tube experiment value. No autoignition or flashback was observed at the conditions tested.
Design of flapping mechanisms based on transverse bending phenomena in insects (2006)

In this paper, we investigate designs of flapping mechanisms that allow high amplitude and high frequency of flapping. The mechanism utilizes springs and passive flapping, a concept motivated from the study of wing motion of insects and hummingbirds. The mechanisms simulate transverse bending effect of insect wings to achieve high flapping amplitudes. Different configurations of flapping mechanism are studied using dynamic simulations and quasi-steady aerodynamics. Apart from high amplitude, the results show that higher lift can be generated using these designs
Packet Data Flow Control in Evolved WCDMA Networks (2005)

The key idea of the new, shared high-capacity channel HSDPA, is to adapt the transmission rate to fast variations in the current radio conditions, thus enabling download peak data rates much higher than what WCDMA can offer today. This has induced a need for data that traverses the mobile network to be intermediately buffered in the Radio Base Station, RBS. A scheduling algorithm then basically selects the user with the most beneficial instantaneous radio conditions for access to the high-speed channel and transmission of its data over the air interface. The purpose of this thesis is to design a flow control algorithm for the transmission of data packets between the network node directly above the RBS, the RNC, and the RBS. This flow control algorithm should keep the level of the buffers in the RBS on such a level that the air interface may be fully utilized. Yet it is not desirable with large buffers since e.g., this induces longer round-trip times as well as loss of all data in the buffers whenever the user moves to another cell and a handover is performed. Theoretical argumentations and simulations show that both of these requirements may be met, even though it is a balancing act. Suggested is a control-theoretic framework in which the level in the RBS buffers are kept sufficiently large by taking into account predictions of future outflow over air and by using methods to compensate for outstanding data on the transport network. This makes it possible to keep the buffer levels stable and high enough to fully utilize the air interface. By using a more flexible adaptive control algorithm, it is shown possible to reach an even higher utilization of the air interface with the same or even lower buffering, which reduces the amount of data lost upon handovers. This loss is shown to be even more reduced by actively taking system messages about upcoming handover events into account as well.
Nitric Oxide Regulation of Permeability in Human Cervical and Vaginal Epithelial Cells and in Human Endothelial Cells (2003)

This paper reviews new models of nitric-oxide (NO)-related regulation of transepithelial and transendothelial permeability in normal tissues, with emphasis on physiological relevance of the data. Novel data obtained in cultured human epithelial and endothelial cells indicate that NO can originate from different intracellular sources, and can be selectively regulated and employed to activate various intracellular mechanisms that will affect the permeability via different mechanisms. These models may be important for understanding NO regulation of permeability in vivo.
Design and analysis of a gracefully degrading interleaved memory system (1990)

The organization of interleaved memories in such a way that faults in the memory system degrade the performance in a graceful manner is studied. Attention is restricted to an interleaved memory system that starts out with 2/sup q/ memory banks and uses a low-order interleaving scheme. The motivation and design objectives of the memory system are described. A new reconfiguration scheme and the design of the hardware needed to implement it are presented. The reconfiguration scheme is evaluated using trace-driven simulation for a number of benchmarks. The ideas presented can easily be extended to other interleaved memory schemes.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Tumor-Associated Alterations in Caspase-14 Expression in Epithelial Malignancies (2005)

The findings reveal tumor-specific alterations in caspase-14 expression and suggest that differences in its expression may define subsets of epithelial cancers with distinct clinical behaviors.