gebhart/patrepeval huggingface dataset:
Indikatorkoordinationsplan i en byggprocess (2010)

På många ställen i världen sker idag en kraftig urbanisering, vilket innebär en folkförflyttning från landsbygd till stadsområde. Kina är ett av de länder som har en kraftig urbanisering och där 15 miljoner kineser lämnar landsbygden varje år för att arbeta i städerna. Mot bakgrunden av detta och att Kina har de högsta koldioxidutsläppen i världen, så planerar nu Kina för 50 nyproducerade eko-städer. &#13;\nEn av dessa städer blir miljonstaden Caofeidian i Kina. Denna stad har svenska teknikkonsultföretaget SWECO fått till uppgift att analysera och ta fram strategi för hållbar planering. Att skapa stora städer ökar möjligheterna för att komma till rätta med olika problem. Städer är en bra bas för att skapa smarta lösningar vad gäller energi, vatten och avfall, samt att integrera bebyggelse- och transportplanering. &#13;\nSWECO har högt ställda mål för Caofeidian vad gäller ekologisk, ekonomisk och social hållbarhet. Bland annat är staden planerad för att bli klimatneutral, med uppemot 95 procent förnyelsebar energi. Planerna är även att staden skall vara flexibel, resurs- och kostnadseffektiv, tillgänglig och inte minst vacker. För att uppnå dessa uppsatta mål har SWECO utarbetat ett indikatorsystem, vilket med 140 indikatorer ska mäta olika tillstånd under planeringstiden samt med den färdiga staden i drift. Dock finns det idag problem med att arbeta utefter indikatorer eftersom SWECO inte kan lämna garantier för andra aktörer i byggprocessen. Det krävs att man indikatorsäkrar projektet som helhet för att SWECO ska kunna lämna garantier till beställaren, så att kraven på en hållbar stad uppnås.&#13;\nDenna uppsats består av tre delar: teori- och metoddel, förstudie samt avslutning med diskussion och slutsats. I teori och metoddelen redovisas det vetenskapliga förhållningssättet till förstudien. Teorin förklarar påståenden och företeelser vilka beskriver förstudiens problematik. Metoden har använts för att skapa en tillförlitlig kunskapsbas. Den beskriver författarnas tillvägagångssätt i projektet, vilket även är till hjälp för andra intressenter att skapa sin egen indikatorkoordinationsplan (IKP). Förstudien utvecklar ett verktyg för att effektivisera styrningen av indikatorer från beställning till stadens förvaltning. På så sätt kan olika aktörer lämna större garantier för en hållbar slutprodukt till beställaren. &#13;\nProjektets förstudie är fokuserad på indikatorkoordinering i byggprocessens olika skeden. Stadens totala exploatering är på 150 km2. Denna uppsats avgränsas till den första detaljetappen, vilket motsvarar 12 km2. Resultatet av förstudien är en IKP som möjliggör förbättrad styrning mot en hållbar slutprodukt. I studien ingår även en riskanalys där det framgår vilka risker som är av betydelse vid inrättandet av en IKP. &#13;\nI projektets avslutning diskuteras fördelar och nackdelar med att integrera IKP:n i byggprocessen. Resonemangen förs utifrån problemställningar som formuleras i studiens inledning. Avslutningen belyser även förslag på fortsatta studier inom området, för att skapa en bättre förståelse kring värdet av att koordinera indikatorer i en process.
Isolation from Streptomyces of a Novel Naphthoquinone Compound, Naphthablin, That Inhibits Abl Oncogene Functions. (1995)

In the course of our screening for inhibitors of abl oncogene function, a culture filtrate of Streptomyces aculeolatus, induced normal flat morphology in v-abl-expressing NIH3T3 cells. The active substance was isolated through ethyl acetate extraction, silica gel column chromatography, and reverse-phase HPLC. Mass and NMR spectroscopy including HMBC revealed that it had a novel naphthoquinone structure with a monoterpene, and we named it "naphthablin". Naphthablin inhibited Abl-induced morphological transformation in v-ablts-NIH3T3 cells at around 30 micrograms/ml, and specifically inhibited RNA synthesis.
EUV metal oxide hybrid photoresists: ultra-small structures for high-resolution patterning (2018)

Extreme ultraviolet (EUV) lithography, using 13.5 nm radiation, is considered one of the most prominent candidates for next generation lithography. The main challenge for EUV resists is to simultaneously satisfy resolution, LWR (line-width roughness) and sensitivity requirements according to the ITRS roadmap<sup>1</sup>. Over the past few years, our main effort has been to focus on ZrO<sub>2</sub> and HfO<sub>2</sub> nanoparticle-based photoresists. However, both Zr and Hf are relatively low EUV absorbing metals<sup>2</sup>, and integration of high EUV absorption elements is considered to be a more promising route to further improve lithographic performance under EUV radiation. Here, we demonstrate novel zinc oxide-based nanoparticle photoresists, possessing small particle size, good solubility in spin-coating solvents, good film-forming abilitie and patterning by incorporating a photo-acid generator or photo-radical generator.
Double polarization anisotropy in asymmetric, coupled quantum wells under anisotropic, inplane strain (2002)

A novel coupled-quantum-well system is described in which the inplane, anisotropic strain in successive well layers alternates between compression and tension. A polarization anisotropy in the interband optical matrix elements that arises due to anisotropic strain is reversed between the compressive and tensile cases. Hence, transitions associated with the different well layers have reversed polarization anisotropies. The structure of interest has great flexibility in the energies of successive interband transitions, and in the size of the anisotropy of the various transitions. The structure can be used in describing quantum-well properties, in optical multiplexing, and in devices such as modulators.
The effects of diaspirin crosslinked hemoglobin (DCLHb) on oxygenation, perfusion and resuscitation: preclinical experience (1998)

Background: Whole body hyperthermia induced by radiative systems has been used in therapy of malignant diseases for more than ten years. Von Ardenne and co-workers have developed the 'systemiche Krebs-Mehrschritt-Therapic' (sKMT), a combined regime including whole body hyperthermia of 42C, induced hyperglycaemia and relative hyperoxaemia with additional application of chemotherapy. This concept has been employed in a phase I/II clinical study for patients with metastatic colorectal carcinoma at the Virchow-Klinikum since January 1997. Methods: The sKMT concept was performed eleven times under intravenous general anaesthesia, avoiding volatile anaesthetics. Core temperatures of up to 42C were reached stepwise by warming with infrared-A-radiation (IRATHERM 2000). During the whole procedure blood glucose levels of 380-450 mg/dl were maintained as well as PaO 2 levels above 200 mmHg. Extensive invasive monitoring was performed in all patients including measurements with the REF-Ox-Pulmonary artery catheter with continuous measuring of mixed venous saturation (Baxter Explorer) and invasive monitoring of arterial blood pressure. Data for calculation of hemodynamic and gas exchange parameters were collected four times, at temperatures of 37C, 40C, 41.8-42C and 39C, during measurements FiO 2 was 1.0 at all times. Fluids were given in order to keep central-venous and Wedge pressure within normal range during the whole procedure. Statistics were performed using the Wilcoxon Test. Results: Statistically significant differences were found between heart rate, cardiac index and systemic vascular resistance comparing data at 37C and 42C. Heart rate and cardiac index increased to a maximum at 42C (P < 0.0001) whereas systemic vascular resistance had its minimum at 42C (P < 0.0001). Mean arterial pressure dropped with increasing temperature, differences were not significant. Calculation of stroke volume index and ventricular volumes showed only a slight decrease in endsystolic volumes with increasing temperature, the resulting differences in right ventricular ejection fraction were marginally significant (P = 0.038) comparing 42C to baseline. Right ventricular stroke work index as well as mean pulmonary arterial pressure increased at 42C (P = 0.0115 and P = 0.0037), pulmonary vascular resistance only dropped little compared to systemic vascular resistance, left ventricular stroke work index even dropped with increasing temperature, though showing no significant difference. Values for mixed venous oxygen saturation did not vary during therapy, pulmonary right-left shunt showed a temperature associated increase (P = 0.0323) to a maximum at 42C. Conclusion: Under the procedure of sKMT cardiac function in patients, who do not have any pre-existing cardiac impairment, can be maintained almost unchanged, ie with normal right and left ventricular pressure, despite an increase in right ventricular stroke work
Multiparametric Auditory Receptive Field Organization Across Five Cortical Fields in the Albino Rat (2007)

The auditory cortex of the rat is becoming an increasingly popular model system for studies of experience-dependent receptive field plasticity. However, the relative position of various fields within the auditory core and the receptive field organization within each field have yet to be fully described in the normative case. In this study, the macro- and micro-organizational features of the auditory cortex were studied in pentobarbital-anesthetized adult rats with a combination of physiological and anatomical methods. Dense microelectrode mapping procedures were used to identify the relative position of five tonotopically organized fields within the auditory core: primary auditory cortex (AI), the posterior auditory field (PAF), the anterior auditory field (AAF), the ventral auditory field (VAF), and the suprarhinal auditory field (SRAF). AI and AAF both featured short-latency, sharply tuned responses with predominantly monotonic intensity-response functions. SRAF and PAF were both characterized by longer-latency, broadly tuned responses. VAF directly abutted the ventral boundary of AI but was almost exclusively composed of low-threshold nonmonotonic intensity-tuned responses. Dual injection of retrograde tracers into AI and VAF was used to demonstrate that the sources of thalamic input from the medial geniculate body to each area were essentially nonoverlapping. An analysis of receptive field parameters beyond characteristic frequency revealed independent spatially ordered representations for features related to spectral tuning, intensity tuning, and onset response properties in AI, AAF, VAF, and SRAF. These data demonstrate that despite its greatly reduced physical scale, the rat auditory cortex features a surprising degree of organizational complexity and detail.
Performance of FBMC Multiple Access for relaxed synchronization cellular networks (2014)

Relaxed synchronization and access to fragmented spectrum are considered essential for future generations of wireless networks in order to reduce physical channel signaling. Frequency Division Multiple Access for Filter Bank Multicarrier (FBMC) modulation provides promising performance without strict synchronization requirements contrary to conventional Orthogonal Frequency Division Multiplexing (OFDM). In this paper, the architecture of a FBMC receiver suitable for this scenario is considered and its performance is compared against OFDM. The maximum achievable capacity of an asynchronous uplink transmission is analyzed when limited amount of feedback information on timing misalignment and power control is available. The proposed receiver architecture based on frequency domain processing combined with the fair frequency localization of the FBMC prototype filter provides an architecture that allows for more efficient multiuser asynchronous reception compared to OFDM.
Lensfree microscopy: A new framework for the imaging of viruses, bacteria, cells and tissue (2015)

Lensfree imaging is an emerging microscopy technique based on in-line holography as invented by Gabor in 1948. Albeit the existence of the method since decades, the recent development of digital sensors, helped the realization of its full potential. Over the recent years, innovations and improvements in CMOS imaging technology design and fabrication have allowed to decrease the pixel pitch down to ~1μm and the number of pixels has dramatically increased up to 250 million of pixels. As a result, the performance of lensfree microscopy, which features a bare CMOS sensor without any magnification optics, have tremendously increased while keeping the design simple, robust, and at a reasonable low cost. The detection ability improved from 10 μm (cell) in 2009, to 1 μm (bacteria) in 2010, down to 100 nm beads in 2012, paving the way to the detection of viruses in 2013.
Low‐rank magnetic resonance fingerprinting (2018)

We have shown through retrospective and prospective experiments that by exploiting the low-rank nature of the MRF signal, FLOR recovers the MRF temporal undersampled images and provides more accurate parameter maps compared to previous iterative approaches.
Figure S1 from Quantitative Whole Genome Sequencing of Circulating Tumor Cells Enables Personalized Combination Therapy of Metastatic Cancer (2023)

&lt;p&gt;Distribution of allele fraction of inherited and somatic variants before and after filtering. This figure is similar to Fig. 4a, but includes a plotting of all somatic variants before filtering (black), which contains a large number of false positive errors.&lt;/p&gt;
Security Evaluation of Bistable Ring PUFs on FPGAs using Differential and Linear Analysis (2014)

Physically Unclonable Function (PUF) is expected to be an innovation for anti-counterfeiting devices for secure ID generation, authentication, etc.In this paper, we propose novel methods of evaluating the difficulty of predicting PUF responses (i.e.PUF outputs), inspired by well-known differential and linear cryptanalysis.According to the proposed methods, we perform a first third-party evaluation for Bistable Ring PUF (BR-PUF), proposed in 2011.The BR-PUFs have been claimed that they have a resistance against the response predictions.Through our experiments using FPGAs, we demonstrate, however, that BR-PUFs have two types of correlations between challenges and responses, which may cause the easy prediction of PUF responses.First, the same responses are frequently generated for two challenges (i.e.PUF inputs) with small Hamming distance.A number of randomly-generated challenges and their variants with Hamming distance of one generate the same responses with the probability of 0.88, much larger than 0.5 in ideal PUFs.Second, particular bits of challenges in BR-PUFs have a great impact on the responses.The value of responses becomes '1' with the high probability of 0.71 (> 0.5) when just particular 5 bits of 64-bit random challenges are forced to be zero or one.In conclusion, the proposed evaluation methods reveal that BR-PUFs on FPGAs have some correlations of challenge-response pairs, which helps an attacker to predict the responses.
A chimeric protein encompassing hepatitis C virus epitopes is able to elicit both humoral and cell‐mediated immune responses in mice (2014)

Hepatitis C virus (HCV) infection is a worldwide health problem. Vaccines against this pathogen are not available and advances in this field are limited because of the high genetic variability of the virus, inaccessibility of animal models, and incomplete definition of immunological correlates of protection. In the present work, a chimeric protein, Eq1, encompassing HCV amino acid regions from structural antigens, was generated. Eq1 was expressed in GC-366 bacterial cells. After cell disruption, Eq1 was purified from the insoluble fraction by sequential steps of differential solubilization and metal chelating affinity chromatography. Eq1 was specifically recognized by anti-HCV positive human sera. Moreover, immunization of BALB/c mice with different doses of Eq1 formulated either in Alum or Freund's incomplete adjuvant elicited both humoral- and cellular-specific immune responses. Doses of 20 µg of Eq1 induced the strongest cell-mediated immune responses and only the formulation of this dose in Alum elicited a neutralizing antibody response against heterologous cell culture HCV. All these data together indicate that Eq1 is immunogenic in mice and might be an interesting component of vaccine candidates against HCV infection.
Author response: Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome (2020)

Hypoplastic left heart syndrome is reflected by reduced proliferative capacity of patient iPSC-derived cardiomyocytes and requires the activity of LRP2/APOB proteins, likely in conjunction with SHH and WNT signaling pathways.
Evaluation of the Analytical Specificity of SCCA-IGM Assay for Monitoring Patients with Cirrhosis (2009)

Background and aim An increasing number of clinical data suggests the importance of the assessment of serum levels of the squamous cell carcinoma antigen (SCCA)-lgM immune complex for the diagnosis of hepatocellular carcinoma (HCC). In addition, monitoring of SCCA-IgM immune complexes has been described as a useful prognostic approach in patients with cirrhosis since the progressive increase of SCCA-IgM over time is associated with a higher risk of HCC development. Because other assays in patients with cirrhosis have been affected by interfering IgMs, the aim of the present study was to assess the specificity of SCCA-IgM reactivity in cirrhotic patients by evaluating SCCA-IgM detection dependence on different capturing phases and by measuring the recovery of SCCA-IgM reactivity after serum fractionation. Patients and methods Serum samples from 82 patients with cirrhosis (M/F ratio 3/1; mean age ± SD: 56 ± 9 years) were collected at the Liver Unit of the Department of Clinical and Experimental Medicine, University of Padua, according to the approved institutional procedures. Serum levels of SCCA-IgM were measured using two different ELISA tests: the reference assay based on a rabbit oligoclonal anti-human SCCA antibody (Hepa IC, Xeptagen, Italy) and a dedicated ELISA with a mouse monoclonal anti-SCCA as capture antibody. Results Serum levels of SCCA-IgM measured with the reference assay (median value 87 AU/mL) were higher than levels measured with the mouse monoclonal test (median value 78 AU/mL), but the differences were not statistically significant (Mann-Whitney U test, p&gt;0.05). When SCCA-IgM levels measured with both tests were compared, a linear correlation was found (r = 0.77, p &lt; 0.001). An in silico analysis using available structural data of SCCA showed the presence of up to three putative antigenic sites localized on the SCCA surface, thus providing evidence that the test with the mouse monoclonal anti-SCCA antibody could underestimate the total circulating immune complexes due to the steric hindrance of the enormous mass of IgM (900 kDa) that could mask on the SCCA (45 kDa) surface the binding site recognized by the monoclonal antibody. To show that the SCCA-IgM assay was not affected by interfering IgMs, we measured the recovery of SCCA-IgM reactivity after serum fractionation of ten of the most reactive samples in both assays. Total recovery of SCCA-IgM reactivity was obtained with both assays in the fractions corresponding to components with higher molecular weight than IgM and SCCA (&gt;2000 kDa). Conclusions The results of this study indicate that the reactivity measured in cirrhotic patients is related only to SCCA-IgM immune complexes and is not affected by other serum components, supporting the analytical specificity of the SCCA-IgM assay and validating the importance of SCCA-IgM as a risk biomarker for HCC development.
Caffeic acid phenethyl ester inhibits the inflammatory effects of interleukin-1β in human corneal fibroblasts (2014)

These anti-inflammatory effects of CAPE may be expected to inhibit the infiltration of leukocytes into the corneal stroma in vivo.
Caveat Emptor: The Heat Is “ON”—An In Vivo Evaluation of the Thulium Fiber Laser and Temperature Changes in the Porcine Kidney During Dusting and Fragmentation Modes (2021)

<b><i>Introduction:</i></b> We sought to examine the intrarenal fluid and tissue temperature alterations during dusting and fragmentation with the thulium fiber laser (TFL) in an <i>in vivo</i> porcine kidney. <b><i>Materials and Methods:</i></b> In two female Yorkshire pigs, temperature was continuously measured within the upper, interpolar, and lower calices along with the renal pelvis using multipoint thermal sensor probes; another temperature probe was situated at the tip of the ureteroscope. Four experimental protocols were performed for each animal: dual lumen ureteroscope with both warmed (37°C) irrigation and room temperature (20°C-22°C) irrigation and single lumen ureteroscope with warmed and room temperature irrigation. Of note, in each pig, one kidney underwent ureteroscopy (URS) with a 14F ureteral access sheath (UAS) in place, whereas the other kidney had no UAS placed. A 200-μm TFL fiber was fired at three laser settings: (1) dusting at 0.5 J, 80 Hz (40 W) with continuous activation until 5 minutes expired or a temperature of 44°C was reached, (2) low-power fragmentation 1 J, 10 Hz, (10 W), and (3) high-power fragmentation at 1.5 J, 20 Hz (30 W). In all cases, the pulse width was 1 ms. For fragmentation, the laser was activated for 10 seconds with a 2-second intermission for a 1-minute period (five cycles). <b><i>Results:</i></b> In the absence of a UAS, in all but one circumstance, temperatures reached or exceeded 44°C at all laser settings with the use of either warm or room temperature irrigation fluid, regardless of the type of ureteroscope used. Of concern, temperatures recorded at the tip of the URS were 4°C to 22°C less than the temperatures recorded in the renal calices. In contrast, with a 14F UAS in place, six distinct groups had temperatures that did not exceed 44°C, specifically at low- and high-power fragmentation settings with room temperature irrigation for both sets of ureteroscopes and at dusting and low-power fragmentation settings with warm temperature irrigation solely for the single lumen ureteroscope. Temperatures recorded at the tip of the ureteroscope with the deployment of a UAS yielded temperature differences ranging from 17°C less to 19°C more than the renal calices. <b><i>Conclusions:</i></b> TFL is a novel laser technology for lithotripsy. In the absence of a UAS, high-power TFL fragmentation settings in particular may create temperatures within the collecting system that could result in urothelial tissue injury. Of note, peak temperatures recorded at the tip of the ureteroscope may misrepresent the actual intrarenal temperature during TFL laser lithotripsy.
Knowledge Graph Embedding using Graph Convolutional Networks with Relation-Aware Attention (2021)

Knowledge graph embedding methods learn embeddings of entities and relations in a low dimensional space which can be used for various downstream machine learning tasks such as link prediction and entity matching. Various graph convolutional network methods have been proposed which use different types of information to learn the features of entities and relations. However, these methods assign the same weight (importance) to the neighbors when aggregating the information, ignoring the role of different relations with the neighboring entities. To this end, we propose a relation-aware graph attention model that leverages relation information to compute different weights to the neighboring nodes for learning embeddings of entities and relations. We evaluate our proposed approach on link prediction and entity matching tasks. Our experimental results on link prediction on three datasets (one proprietary and two public) and results on unsupervised entity matching on one proprietary dataset demonstrate the effectiveness of the relation-aware attention.
Validation of a New Noninvasive Device for the Monitoring of Peak Endocardial Acceleration in Pigs: Implications for Optimization of Pacing Site and Configuration (2008)

Noninvasive PEA measurement allows monitoring of left ventricular contractility and may be a useful tool to detect global effect of ventricular ischemia and to optimize the choice of both pacing site and pacing configuration.