gebhart/patrepeval huggingface dataset:
Ophthalmic glucose monitoring using disposable contact lenses (2005)

We have developed a range of disposable and colorless tear glucose sensing contact lenses, using off-the-shelf lenses embedded with new water soluble, highly fluorescent and glucose sensitive boronic acid containing fluorophores. The new lenses are readily able to track tear glucose levels and therefore blood glucose levels, which are ideally suited for potential use by diabetics. The fluorescence responses from the lenses can be monitored using simple excitation and emission detection devices. The novelty of our approach is two fold. Firstly, the notion of sensing extremely low glucose concentrations in tears, which track blood levels, by our contact lens approach, and secondly, the unique compatibility of our new glucose signaling probes with the internal mildly acidic contact lens environment. The new lenses are therefore ideal for the noninvasive and continuous monitoring of tear glucose, with a 15 minute response time, and a measured shelf life in excess of 3 months. In this invited article, we show that fluorescence based signaling using plastic disposable lenses, which have already been industrially optimized with regard to vision correction and oxygen / analyte permeability etc, may a notable alternative to invasive and random finger pricking, the most widely used glucose monitoring technology by diabetics.
Isolation and structure determination of a new lantibiotic cinnamycin B from Actinomadura atramentaria based on genome mining (2016)

New lantibiotic cinnamycin B was isolated from the extract of Actinomadura atramentaria NBRC 14695(T), based on genome mining and chemical investigation. The partial structure of cinnamycin B was established by 2D NMR experiments, which indicated that cinnamycin B had same methyl lanthionine bridging pattern with cinnamycin. The reduction with NaBH4-NiCl2 afforded the reduced cinnamycin B, and MS/MS experiment indicated the presence of hydroxy asparatic acid in the molecule. Cinnamycin B showed an antibacterial activity against Streptomyces antibioticus with dosage of 5 μg (0.5μL, 10 mg/mL solution) at spot-on-lawn testing method. The gene cluster of cinnamycin B on the genome of A. atramentaria was identified and discussed in comparison with that of cinnamycin.
The Efficacy of Multiparametric Magnetic Resonance Imaging and Magnetic Resonance Imaging Targeted Biopsy in Risk Classification for Patients with Prostate Cancer on Active Surveillance (2016)

Magnetic resonance imaging targeted biopsies increased the detection of higher grade cancer among men on active surveillance compared to systematic biopsy alone. However, a clinically relevant proportion of higher grade cancer was detected using only systematic biopsy. Despite the improved detection of disease progression using magnetic resonance imaging targeted biopsy, systematic biopsy cannot be excluded as part of surveillance for men with low risk prostate cancer.
HUMIDIFIED AIR EFFECT ON PUPIL SIZE DURING FLUID–AIR EXCHANGE (2001)

ÇEKİÇ, OSMAN MD; OHJI, MASAHITO MD; HAYASHI, ATSUSHI MD; FANG, XIAO Y. MD; KUSAKA, SHUNJI MD; TANO, YASUO MD Author Information
A Fan-Beam Radiator Using Waveguide's Narrow Wall for Horizontal Polarization and High Power (2011)

A configuration for a narrow-band rugged high-power antenna with a horizontally polarized fan-beam radiation pattern is proposed. This antenna is a longitudinal aperture array in the narrow wall of an air-filled rectangular waveguide, and it produces intentional electromagnetic interference for military purposes. It is to be approximately vertically front mounted on a land vehicle operating in a war zone for neutralizing hot-wire detonators from a safe distance. Computational electromagnetic analysis is used for analyzing the individual array elements, and then standard microwave network analysis is used for the initial array design. Full-wave analysis is used to validate the resulting array design and an improved array design. Experimental data at 10 GHz is presented to further validate the full-wave analysis. A theoretical estimate for the power handling capability is presented for the final array design scaled to operate at a frequency in the industrial frequency band (902-928 MHz).
Crisis of National Finanece and Great Reshuffle of Government Administration (1980)

departmental bulletin paper
An introduction to primary skin imaging (2013)

Dermatology is a field in which clinical examination is heavily relied upon for diagnosis. When required, a tissue biopsy may also be performed to confirm the diagnosis. Recent advances in imaging techniques have been applied to cutaneous lesions to improve diagnostic accuracy without the need for biopsy. These new imaging techniques are reviewed for their developing role in dermatology.
Ultrasound -Assisted Gene Transfer to Adipose Tissue-Derived Stem∕Progenitor Cells (ASCs) (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Yoshitaka Miyamoto, Hitomi Ueno, Rei Hokari, Wenji Yuan, Shuichi Kuno, Takashi Kakimoto, Shin Enosawa, Yoichi Negishi, Kiyoshi Yoshinaka, Yoichiro Matsumoto, Toshio Chiba, Shuji Hayashi; Ultrasound ‐Assisted Gene Transfer to Adipose Tissue‐Derived Stem/Progenitor Cells (ASCs). AIP Conference Proceedings 12 September 2011; 1359 (1): 377–382. https://doi.org/10.1063/1.3607937 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
EU FP7 INFSO-ICT-317669 METIS, D3.2 First performance results for multi-node/multi-antenna transmission technologies (2014)

This deliverable describes the current results of the multi-node/multi-antenna technologies investigated within METIS and analyses the interactions within and outside Work Package 3. Furthermore, it identifies the most promising technologies based on the current state of obtained results. This document provides a brief overview of the results in its first part. The second part, namely the Appendix, further details the results, describes the simulation alignment efforts conducted in the Work Package and the interaction of the Test Cases. The results described here show that the investigations conducted in Work Package 3 are maturing resulting in valuable innovative solutions for future 5G systems.
Overlay improvement roadmap: strategies for scanner control and product disposition for 5-nm overlay (2011)

To keep pace with the overall dimensional shrink in the industry, overlay capability must also shrink proportionally. Unsurprisingly, overlay capability &lt; 10 nm is already required for currently nodes in development, and the need for multi-patterned levels has accelerated the overlay roadmap requirements to the order of 5 nm. To achieve this, many improvements need to be implemented in all aspects of overlay measurement, control, and disposition. Given this difficult task, even improvements involving fractions of a nanometer need to be considered. These contributors can be divided into 5 categories: scanner, process, reticle, metrology, and APC. In terms of overlay metrology, the purpose is two-fold: To measure what the actual overlay error is on wafer, and to provide appropriate APC feedback to reduce overlay error for future incoming hardware. We show that with optimized field selection plan, as well as appropriate within-field sampling, both objectives can be met. For metrology field selection, an optimization algorithm has been employed to proportionately sample fields of different scan direction, as well as proportional spatial placement. In addition, intrafield sampling has been chosen to accurately represent overlay inside each field, rather than just at field corners. Regardless, the industry-wide use of multi-exposure patterning schemes has pushed scanner overlay capabilities to their limits. However, it is now clear that scanner contributions may no longer be the majority component in total overlay performance. The ability to control correctable overlay components is paramount to achieving desired performance. In addition, process (non-scanner) contributions to on-product overlay error need to be aggressively tackled, though we show that there also opportunities available in active scanner alignment schemes, where appropriate scanner alignment metrology and correction can reduce residuals on product. In tandem, all these elements need to be in place to achieve the necessary overlay roadmap capability for current development efforts.
Regulation of fatty acid production in transgenic crops (2002)

Conference Abstract| October 01 2002 Regulation of fatty acid production in transgenic crops A.J. Kinney; A.J. Kinney 1Crop Genetics Research, DuPont Experimental Station, Wilmington, DE 19803 Search for other works by this author on: This Site PubMed Google Scholar E. Cahoon; E. Cahoon 1Crop Genetics Research, DuPont Experimental Station, Wilmington, DE 19803 Search for other works by this author on: This Site PubMed Google Scholar W.D. Hitz W.D. Hitz 1Crop Genetics Research, DuPont Experimental Station, Wilmington, DE 19803 Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (2002) 30 (5): A104. https://doi.org/10.1042/bst030a104a Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation A.J. Kinney, E. Cahoon, W.D. Hitz; Regulation of fatty acid production in transgenic crops. Biochem Soc Trans 1 October 2002; 30 (5): A104. doi: https://doi.org/10.1042/bst030a104a Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2002 Biochemical Society2002 Article PDF first page preview Close Modal You do not currently have access to this content.
Effect of Cocatalysts and Solvent on Selective Ethylene Oligomerization (2015)

Ethylene oligomerization activities of chromium catalysts stabilized by different dipyrrole-based ancillary ligands, [(Ph2C(C4H4N)2)] (2), [Ph2C(C4H4N)(C5H6N)] (3), [(Et)2C(C4H4N)2] (4), and [(C6H5)(C5H4N)C(C4H4N)(C5H6N)] (5), have been investigated using different activation methods, and the results have been compared with the commercial Chevron–Phillips ethylene trimerization system. Upon activation with triethylaluminum (TEA), chromium catalysts stabilized by dipyrrole-based ligands 2–5 showed a lower activity and selectivity compared to the Chevron–Phillips trimerization system based on 2,5-dimethylpyrrole (1) as the ancillary ligand. However, unprecedented increases in both activity and selectivity have been observed by carrying out the oligomerization in methylcyclohexane using depleted-methylaluminoxane (DMAO) along with triisobutylaluminum (TIBA) (1:2 ratio) as cocatalyst system under mild conditions, even for the Chevron–Phillips system itself. Well-defined chromium complexes, [(Ph2C(C4H3N)2)Cr(Cl)(THF)3] (6) and {[Ph2C(C4H3N)(C5H6N]Cr(THF)(μ-Cl)}2 (7), have been synthesized and fully characterized. Upon activating with MAO, catalyst 7 produced a statistical distribution of oligomers, whereas under identical oligomerization conditions catalyst 6/MAO was found to be inactive. The use of MeAlCl2 as cocatalyst to activate 7 resulted in the switching of the catalyst’s behavior from producing a statistical distribution of LAOs to the selective trimerization of ethylene to 1-hexene. The addition of dialkylzinc along with MAO resulted in an unprecedented activity increase.
Poster session III * Friday 10 December 2010, 08:30-12:30 (2010)

no. P674
Bat pluripotent stem cells reveal unique entanglement between host and viruses (2022)

Abstract Bats have evolved features unique amongst mammals, including flight, laryngeal echolocation, and certain species have been shown to have a unique immune response that may enable them to tolerate viruses such as SARS-CoVs, MERS-CoVs, Nipah, and Marburg viruses. Robust cellular models have yet to be developed for bats, hindering our ability to further understand their special biology and handling of viral pathogens. To establish bats as new model study species, we generated induced pluripotent stem cells (iPSCs) from a wild greater horseshoe bat ( Rhinolophus ferrumequinum ) using a modified Yamanaka protocol. Rhinolophids are amongst the longest living bat species and are asymptomatic carriers of coronaviruses, including one of the viruses most closely related to SARS-CoV-2. Bat induced pluripotent stem (BiPS) cells were stable in culture, readily differentiated into all three germ layers, and formed complex embryoid bodies, including organoids. The BiPS cells were found to have a core pluripotency gene expression program similar to that of other species, but it also resembled that of cells attacked by viruses. The BiPS cells produced a rich set of diverse endogenized viral sequences and in particular retroviruses. We further validated our protocol by developing iPS cells from an evolutionary distant bat species Myotis myotis (greater mouse-eared bat) non-lethally sampled in the wild, which exhibited similar attributes to the greater horseshoe bat iPS cells, suggesting that this unique pluripotent state evolved in the ancestral bat lineage. Although previous studies have suggested that bats have developed powerful strategies to tame their inflammatory response, our results argue that they have also evolved mechanisms to accommodate a substantial load of endogenous viral sequences and suggest that the natural history of bats and viruses is more profoundly intertwined than previously thought. Further study of bat iPS cells and their differentiated progeny should advance our understanding of the role bats play as virus hosts, provide a novel method of disease surveillance, and enable the functional studies required to ascertain the molecular basis of bats’ unique traits.
Targeting SARS-CoV-2 M3CLpro by HCV NS3/4a Inhibitors: In Silico Modeling and In Vitro Screening (2021)

Currently the entire human population is in the midst of a global pandemic caused by SARS-CoV-2 (<u>S</u>evere <u>A</u>cute <u>R</u>espiratory <u>S</u>yndrome <u>Co</u>rona<u>V</u>irus 2). This highly pathogenic virus has to date caused >71 million infections and >1.6 million deaths in >180 countries. Several vaccines and drugs are being studied as possible treatments or prophylactics of this viral infection. M3CLpro (coronavirus main cysteine protease) is a promising drug target as it has a significant role in viral replication. Here we use the X-ray crystal structure of M3CLpro in complex with boceprevir to study the dynamic changes of the protease upon ligand binding. The binding free energy was calculated for water molecules at different locations of the binding site, and molecular dynamics (MD) simulations were carried out for the M3CLpro/boceprevir complex, to thoroughly understand the chemical environment of the binding site. Several HCV NS3/4a protease inhibitors were tested <i>in vitro</i> against M3CLpro. Specifically, asunaprevir, narlaprevir, paritaprevir, simeprevir, and telaprevir all showed inhibitory effects on M3CLpro. Molecular docking and MD simulations were then performed to investigate the effects of these ligands on M3CLpro and to provide insights into the chemical environment of the ligand binding site. Our findings and observations are offered to help guide the design of possible potent protease inhibitors and aid in coping with the COVID-19 pandemic.
DiscreteMemoryless Networks (2011)

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A Synthetic Retinoid Am80 (Tamibarotene) Rescues the Memory Deficit Caused by Scopolamine in a Passive Avoidance Paradigm (2004)

Memory deficit in rats treated with scopolamine was rescued by several synthetic retinoids, RAR-ligands (Am80, Am555S, Tp80) and an RXR-ligand (HX630). These results may have implications for the treatment of Alzheimer's disease, age-related dementia, Parkinson's disease, and other neurological disorders.
Intracellular or extracellular heat shock protein 70 differentially regulates cardiac remodelling in pressure overload mice (2010)

These results indicate that intracellular and extracellular HSP70 have different roles in the regulation of cardiac remodelling and function in response to hypertension. Extracellular HSP70 is a potential therapeutic target against cardiac hypertrophy and fibrosis.
Impact of Injecting Ground Truth Explanations on Relational Graph Convolutional Networks and their Explanation Methods for Link Prediction on Knowledge Graphs (2022)

Relational Graph Convolutional Networks (RGCNs) are commonly applied to Knowledge Graphs (KGs) for black box link prediction. Several algorithms, or explanations methods, have been proposed to explain the predictions of this model. Recently, researchers have constructed datasets with ground truth explanations for quantitative and qualitative evaluation of predicted explanations. Benchmark results showed state-of-the-art explanation methods had difficulties predicting explanations. In this work, we leverage prior knowledge to further constrain the loss function of RGCNs, by penalizing node embeddings far away from the node embeddings in their associated ground truth explanation. Empirical results show improved explanation prediction performance of state-of-the-art post hoc explanations methods for RGCNs, at the cost of predictive performance. Additionally, we quantify the different types of errors made both in terms of data and semantics.
Chronic Cytomegalovirus Infection and Inflammation Are Associated with Prevalent Frailty in Community‐Dwelling Older Women (2005)

Chronic CMV infection is associated with prevalent frailty, a state with increased morbidity and mortality in older adults; inflammation enhances this effect. Further prospective studies are needed to establish a causal relationship between CMV, inflammation, and frailty.
Influence of Concrete Material Ductility on the Shear Behavior of Stud Connection (2004)

Peer Reviewed
Conformational preferences of the flexible galactofuranose sugar in gas-phase (2023)

In contrast with the predominant pyranose form of galactose, galactofuranose is known to be highly flexible. Such flexibility poses a remarkable challenge in terms of structural studies, thus hindering the in depth understanding of the structure/function relationship in this rare sugar. A thorough computational study based on molecular dynamics and density functional theory supported by vibrational spectroscopy in the gas phase was carried out to provide a better understanding of the instrinsic conformational preferences of galactofuranose. Based on energetic and spectroscopic criteria, we report a subtantially reduced conformational landscape: methyl α-D-galactofuranose adopts E<sub>2</sub>/<sup>1</sup>E conformations and methyl β-D-galactofuranose adopts <sup>1</sup>T<sub>2</sub>/<sup>1</sup>E conformations.
Differences in the management of Crohn’s disease among experts and community providers, based on a national survey of sample case vignettes (2007)

Although experts and community providers are in general consensus about diagnostic decision-making in Crohn's disease, extreme variation exists both between and within groups for key therapeutic decisions in Crohn's disease. We must understand and decrease this variation prior to future efforts of creating explicit quality indicators in Crohn's disease.
Comparing Medicines for Long-Term Treatment of Bipolar Disorder (2021)

Bipolar disorder is a chronic mental illness that causes shifts in mood, energy, and activity. People with bipolar disorder can have high and low moods, known as mania and depression, which differ from usual ups and downs. The disorder may also affect people's ability to think clearly. They may see or hear things that aren't real. Severe episodes may require a hospital stay.
The Design and Performance of Special Purpose Middleware: A Sensor Networks Case Study (2003)

General purpose middleware has been shown to be effective in meeting diverse functional requirements for a wide range of distributed systems. Advanced middleware projects have also supported a single quality-of-service dimension such as real-time, fault tolerance, or small memory footprint. However, there is limited experience supporting multiple quality-of-service dimensions in mid-dleware to meet the needs of special purpose applications. Even though general purpose middleware can cover an entire spectrum of applications by supporting the union of all features required by each application, this approach breaks down for distributed real-time and embedded systems. In particular, features from one dimension such as real-time may interfere with requirements for another dimension such as fault tolerance. Furthermore, the breadth of features supported may interfere with small memory footprint requirements. In this paper, we document the results of our experiences developing special purpose middleware for an emerging class of systems: networked embedded sensors. We make two contributions to the state of the art in customized middleware for distributed real-time and embedded applications. First, we demonstrate that reduced foot-print can be achieved while maintaining or even improving real-time properties. Second, we give evidence that empirical measurement using a representative application is crucial to guide selection of feature subsets from gen-eral purpose middleware.
Symmetry-Breaking Plasmonic Metasurfaces for Broadband Light Bending (2012)

We experimentally demonstrate unparalleled wave-front control in a broadband, optical wavelength range from 1.0 μm to 1.9 μm, using a thin plasmonic layer (metasurface) consisting of a nanoantenna array that breaks the symmetry along the interface.
A closely linked DNA marker for facioscapulohumeral disease on chromosome 4q. (1991)

Close linkage of a hypervariable DNA probe on chromosome 4q (pH30, locus D4S139) has been found with the locus for facioscapulohumeral disease. Three recombinants were identified in a total of 140 meioses, giving a maximum lod score of 36.77 at a recombination fraction of 0.02. All but two of the families studied proved informative with this probe; all informative families showed evidence of linkage (except one family with a single scorable meiosis), making genetic heterogeneity unlikely from our data. The close linkage and highly informative nature of the probe will make it suitable for clinical application in presymptomatic and prenatal diagnosis. We have also confirmed loose linkage with the marker (Mfd22, locus D4S171) used to establish the initial assignment of the disorder to chromosome 4.