gebhart/patrepeval huggingface dataset:
Characterization of Bulk Structure in Zinc Orthotitanate: A Density Functional Theory and EXAFS Investigation (2008)

Development of high‐efficiency multicontaminant sorbents is critical for commercialization of power plants utilizing integrated gasification combined cycle technologies. A known prototypical sorbent for this application is the compound zinc orthotitanate, Zn 2 TiO 4 (ZTO). Previous work has not completely resolved the atomic‐level structure of ZTO. Results from both experimental X‐ray absorption fine structure measurements and density functional theory (DFT) calculations are presented and are in quantitative agreement. The DFT calculations identify the octahedral site occupation of Zn and Ti atoms that give the lowest energy ground state structure. We have supplemented our DFT calculations with a cluster expansion model used to parameterize Monte Carlo (MC) simulations. The results of the MC simulations reveal the temperature dependence of the equilibrium octahedral site occupation in Zn 2 TiO 4 .
Prospects of photonic devices for energy generation, communication, and imaging (2010)

The application area of photonics (semiconductor) devices are expanding, especially in the area of next optical communication, imaging, and energy generation. This paper describes the trends of key photonic devices technologies for communication, imaging, and energy generation. The state-of-the art of technologies in each mentioned applications are included. Focused are mainly on the common device structure which have numerous applications. Finally, future device technologies will also be addressed.
The Road to European Digital Sovereignty with Gaia-X and IDSA (2021)

Digitalization is chewing the world with strong economic and social impacts. Recently, the management of the COVID 19 crisis highlighted the power of digital tools and their impact on stakes such as privacy, surveillance, transparency, and censorship. How nations deal with massive digitalization and master the technologies, and applications that are deployed and used on their soils by their companies and citizens is vividly raised by the U.S. ban on Huawei enforced by the “clean network” strategy. This ban could have set the ground for a technology war between “2 blocks: the digital democracies and the techno-authoritarian regimes” [1], [2].
A current compensation circuit for VRM in the sudden change of the load (2005)

A new current-compensation circuit system for VRM is proposed. The proposed circuit consists of MOSFETs, resistors and capacitors without any discrete magnetic devices. It works during only term of transient response and total power loss is very small. From the simulation result, it is revealed that the output voltage of the VRM has fitted in 5 % of 1.5 V at the load change between 1 A and 50 A. And from the observation result, it is revealed that the descent width of output voltage of VRM has improved about 100 mV of 1.5 V at the load change from 1 A to 10 A.
Zinc Treatment of Wilson's Disease (1984)

Letters and Corrections1 July 1984Zinc Treatment of Wilson's DiseaseGEORGE J. BREWER, M.D., GRETCHEN M. HILL, PH.D., ANANDA S. PRASAD, M.D., PARVIZ RABBANI, PH.D.GEORGE J. BREWER, M.D.Search for more papers by this author, GRETCHEN M. HILL, PH.D.Search for more papers by this author, ANANDA S. PRASAD, M.D.Search for more papers by this author, PARVIZ RABBANI, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-1-144_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We are disturbed by some statements in the editorial by Dr. Deiss (1) in the issue in which our paper on zinc treatment of Wilson's disease (2) appeared.First, Dr. Deiss mistakenly states that we have confirmed that zinc therapy produces a negative copper balance in patients with Wilson's disease. There have not been previous reports on copper balance in patients during zinc treatment of Wilson's disease, so this is an original aspect of our work. One of our concerns has been that various physicians around the country are using zinc as an alternative to penicillamine for...References1. DEISS A. Treatment of Wilson's disease [Editorial]. Ann Intern Med. 1983;99:398-400. LinkGoogle Scholar2. BREWERHILLPRASADCOSSACKRABBANI GGAZP. Oral zinc therapy for Wilson's disease. Ann Intern Med. 1983;99:314-20. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GEORGE J. BREWER, M.D.; GRETCHEN M. HILL, PH.D.; ANANDA S. PRASAD, M.D.; PARVIZ RABBANI, PH.D.Affiliations: The University of Michigan Medical School Ann Arbor, MI 48109 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byElevated copper impairs hepatic nuclear receptor function in Wilson’s diseaseExcretion of copper complexed with thiomolybdate into the bile and blood in LEC rats 1 July 1984Volume 101, Issue 1Page: 144-145KeywordsPatientsZinc ePublished: 1 December 2008 Issue Published: 1 July 1984 PDF downloadLoading ...
Comparative Transcriptome Analysis of Waterlogging-Sensitive and Waterlogging-Tolerant Chrysanthemum morifolium Cultivars under Waterlogging Stress and Reoxygenation Conditions (2018)

Waterlogging stress is among the most severe abiotic stressors in the breeding and the production of <i>Chrysanthemum morifolium.</i> However, the mechanism underlying the response to waterlogging and post-waterlogging reoxygenation in <i>C. morifolium</i> remains unknown. In this study, we compared the differences between the transcriptomes of two chrysanthemum cultivars, i.e., the waterlogging-tolerant cultivar "Nannongxuefeng" and the waterlogging-sensitive cultivar "Qinglu", by performing RNA-seq to elucidate the possible mechanism of waterlogging and reoxygenation in <i>C. morifolium</i>. "Nannongxuefeng" had a higher ethylene production under the waterlogging and reoxygenation conditions. Furthermore, the expression of transcription factors and genes that are involved in the hormone response, N-end rule pathway and ROS signaling significantly differed between the two cultivars. "Nannongxuefeng" and "Qinglu" significantly differed in their response to waterlogging and reoxygenation, providing a deeper understanding of the mechanism underlying the response to waterlogging and guidance for the breeding of <i>C. morifolium</i>.
Asymmetric Multi-Antenna Coded Caching for Location-Dependent Content Delivery (2022)

Efficient usage of in-device storage and computation capabilities are key solutions to support data-intensive applications such as immersive digital experiences. This paper proposes a location-dependent multi-antenna coded caching - based content delivery scheme tailored specifically for wireless immersive viewing applications. First, a novel memory allocation process incentivizes the content relevant to the identified wireless bottleneck areas. This enables a trade-off between local and global caching gains and results in unequal fractions of location-dependent multimedia content cached by each user. Then, a novel packet generation process is carried out during the subsequent delivery phase, given the asymmetric cache placement. During this phase, the number of packets transmitted to each user is the same, while the sizes of the packets are proportional to the corresponding location-dependent cache ratios. In this regard, each user is served with location-specific content using joint multicast beamforming and a multi-rate modulation scheme that simultaneously benefits from global caching and spatial multiplexing gains. Numerical experiments and mathematical analysis demonstrate significant performance gains compared to the state-of-the-art.
High-throughput bactericidal assays for monoclonal antibody screening against antimicrobial resistant Neisseria gonorrhoeae (2023)

ABSTRACT Neisseria gonorrhoeae (gonococcus) is an obligate human pathogen and the etiological agent of the sexually transmitted disease gonorrhea. The rapid rise in gonococcal resistance to all currently available antimicrobials has become a significant public health burden and the need to develop novel therapeutic and prophylactic tools is now a global priority. While high-throughput screening methods allowed rapid discovery of extremely potent monoclonal antibodies (mAbs) against viral pathogens, the field of bacteriology suffers from the lack of assays that allow efficient screening of large panels of samples. To address this point, we developed luminescence-based (L-ABA) and resazurin-based (R-ABA) antibody bactericidal assays that measure N. gonorrhoeae metabolic activity as a proxy of bacterial viability. Both L-ABA and R-ABA are applicable on the large scale for the rapid identification of bactericidal antibodies and were validated by conventional methods. Implementation of these approaches will be instrumental to the development of new medications and vaccines against N. gonorrhoeae and other bacterial pathogens to support the fight against antimicrobial resistance.
Densities and Viscosities of MTBE + Heptane or Octane at p = 0.1 MPa from (273.15 to 363.15) K (2007)

This work presents atmospheric density and viscosity values for methyl tert-butyl ether + heptane or octane over the whole range of compositions from (273.15 to 363.15) K. A vibrating tube densimeter is used for the density measurements, and a Cannon-Fenske viscosimeter is used for the viscosity measurements. Excess molar volumes have been calculated from the density measurements and represented with a Redlich−Kister equation. The root-mean-square deviation of the excess molar volumes from the literature values is 0.018 cm3·mol-1. We also have represented our kinematic viscosity values with a three-body McAllister equation.
Figure S5 from Intratumoral Plasmid IL12 Expands CD8<sup>+</sup> T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti–PD-1 Therapy (2023)

&lt;p&gt;Figure S5&lt;/p&gt;
PuraMatrix Encapsulation of Cancer Cells (2009)

Increasing evidence suggests that culturing cancer cells in three dimensions more accurately recapitulates the complexity of tumor biology. Many of these models utilize reconstituted basement membrane derived from animals which contain a variable amount of growth factors and cytokines that can influence the growth of these cell culture models. Here, we describe in detail the preparation and use of PuraMatrix, a commercially available self assembling peptide gel that is devoid of animal-derived material and pathogens to encapsulate and propagate the ovarian cancer cell line, OVCAR-5. We begin by describing how to prepare the PuraMatrix prior to use. Next, we demonstrate how to properly mix the PuraMatrix and cell suspension to encapsulate the cells in the hydrogel. Upon the addition of cell culture media or injection into a physiological environment, the peptide component of PuraMatrix rapidly self assembles into a 3D hydrogel that exhibits a nanometer scale fibrous structure with an average pore size of 5-200 nm1. In addition, we demonstrate how to propagate cultures grown in encapsulated PuraMatrix. When encapsulated in PuraMatrix, OVCAR-5 cells assemble into three dimensional acinar structures that more closely resemble the morphology of micrometastatic nodules observed in the clinic than monolayer in vitro models. Using confocal microscopy we illustrate the appearance of representative OVCAR-5 cells encapsulated in PuraMatrix on day 1, 3, 5, and 7 post plating. The use of PuraMatrix to culture cancer cells should improve our understanding of the disease and allow us to assess treatment response in more clinically predictive model systems.
Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers (2022)

clinicaltrials.gov (NCT01993836).
Increasing Redox Potential, Redox Mediator Activity, and Stability in a Fungal Laccase by Computer-Guided Mutagenesis and Directed Evolution (2019)

Fungal high-redox-potential laccases (HRPLs) are multi-copper oxidases with a relaxed substrate specificity that is highly dependent on their binding affinity and redox potential of the T1Cu site (E-T1). In this study, we combined computational design with directed evolution to tailor an HRPL variant with increased E-T1 and activity toward high-redox-potential mediators as well as enhanced stability. Laccase mutant libraries were screened in vitro using synthetic highredox-potential mediators with different oxidation routes and chemical natures, while computer-aided evolution experiments were run in parallel to guide benchtop mutagenesis, without compromising protein stability. Through this strategy, the E-T1 of the evolved HRPL increased from 740 to 790 mV, with a concomitant improvement in thermal and acidic pH stability. The kinetic constants for high-redox-potential mediators were markedly improved and were then successfully tested within laccase systems (LMSs). Two hydrophobic substitutions surrounding the T1Cu site appeared to underlie these effects, and they were rationalized at the atomic level. Together, this study represents a proof-of-concept of the joint elevation of the E-T1, redox mediator activity, and stability in an HRPL, making this versatile biocatalyst a promising candidate for future LMS applications and for the development of bioelectrochemical devices.
An Investigation on How Teachers are Using Augmented Reality in Their Lessons (2018)

Educational possibilities using Augmented Reality (AR) have been increasingly recognized by researchers and practitioners. This work aims to characterize teachers who currently use AR and understand their needs, expectations and limitations. Seven teachers and two coordinators were interviewed to understand what tools they are using, as well as why and how they were used. Data have shown that this use is still limited. Content creation was even more limited. We observed the need for authoring tools that are more user-friendly and enable both teachers and students to create content independently, as well as to evaluate learning in more flexible ways.
Immunologic Impact and Clinical Outcomes After Surgical Exposure to Bovine Thrombin (2001)

Bovine thrombin preparations are highly immunogenic and appear to be associated with an increased risk for adverse clinical outcomes during subsequent surgical procedures. The clinical safety of these commonly used preparations needs to be reassessed, and reexposure to these agents should likely be avoided.
Optical Tracking and Digital Quantification of Beating Behavior in Bioengineered Human Cardiac Organoids (2017)

Organoid and organ-on-a-chip technologies are rapidly advancing towards deployment for drug and toxicology screening applications. Liver and cardiac toxicities account for the majority of drug candidate failures in human trials. Liver toxicity generally produces liver cell death, while cardiac toxicity causes adverse changes in heart beat kinetics. In traditional 2D cultures, beating kinetics can be measured by electrode arrays, but in some 3D constructs, quantifying beating kinetics can be more challenging. For example, real time measurements of calcium flux or contractile forces are possible, yet rather complex. In this communication article, we demonstrate a simple sensing system based on software code that optically analyzes video capture files of beating cardiac organoids, translates these files in representations of moving pixels, and quantifies pixel movement activity over time to generate beat kinetic plots. We demonstrate this system using bioengineered cardiac organoids under baseline and drug conditions. This technology offers a non-invasive, low-cost, and incredibly simple method for tracking and quantifying beating behavior in cardiac organoids and organ-on-a-chip systems for drug and toxicology screening.
Developmental outcome of extremely preterm infants is improved after less invasive surfactant application: Developmental outcome after LISA (2020)

At 24 months of age, the LISA-treated infants scored less often PDI < 70 and had similar results in MDI. Infants born at 25 and 26 weeks treated with LISA had lower rates of severe disability. LISA is safe and may be superior.
Reprogramming multipotent tumor cells with the embryonic neural crest microenvironment (2008)

The embryonic microenvironment is an important source of signals that program multipotent cells to adopt a particular fate and migratory path, yet its potential to reprogram and restrict multipotent tumor cell fate and invasion is unrealized. Aggressive tumor cells share many characteristics with multipotent, invasive embryonic progenitors, contributing to the paradigm of tumor cell plasticity. In the vertebrate embryo, multiple cell types originate from a highly invasive cell population called the neural crest. The neural crest and the embryonic microenvironments they migrate through represent an excellent model system to study cell diversification during embryogenesis and phenotype determination. Recent exciting studies of tumor cells transplanted into various embryo models, including the neural crest rich chick microenvironment, have revealed the potential to control and revert the metastatic phenotype, suggesting further work may help to identify new targets for therapeutic intervention derived from a convergence of tumorigenic and embryonic signals. In this mini-review, we summarize markers that are common to the neural crest and highly aggressive human melanoma cells. We highlight advances in our understanding of tumor cell behaviors and plasticity studied within the chick neural crest rich microenvironment. In so doing, we honor the tremendous contributions of Professor Elizabeth D. Hay toward this important interface of developmental and cancer biology.
Supplementary Table S1 from Gene Signatures for the Prediction of Response to Bacillus Calmette-Guérin Immunotherapy in Primary pT1 Bladder Cancers (2023)

Supplementary Table S1 from Gene Signatures for the Prediction of Response to Bacillus Calmette-Guérin Immunotherapy in Primary pT1 Bladder Cancers
FAME: 3D Shape Generation via Functionality-Aware Model Evolution (2020)

We introduce a modeling tool which can evolve a set of 3D objects in a functionality-aware manner. Our goal is for the evolution to generate large and diverse sets of plausible 3D objects for data augmentation, constrained modeling, as well as open-ended exploration to possibly inspire new designs. Starting with an initial population of 3D objects belonging to one or more functional categories, we evolve the shapes through part recombination to produce generations of hybrids or crossbreeds between parents from the heterogeneous shape collection. Evolutionary selection of offsprings is guided both by a functional plausibility score derived from functionality analysis of shapes in the initial population and user preference, as in a design gallery. Since cross-category hybridization may result in offsprings not belonging to any of the known functional categories, we develop a means for functionality partial matching to evaluate functional plausibility on partial shapes. We show a variety of plausible hybrid shapes generated by our functionality-aware model evolution, which can complement existing datasets as training data and boost the performance of contemporary data-driven segmentation schemes, especially in challenging cases. Our tool supports constrained modeling, allowing users to restrict or steer the model evolution with functionality labels. At the same time, unexpected yet functional object prototypes can emerge during open-ended exploration owing to structure breaking when evolving a heterogeneous collection.
An analytical description of balanced steady‐state free precession with finite radio‐frequency excitation (2010)

Conceptually, the only flaw in the standard steady-state free precession theory is the assumption of quasi-instantaneous radio-frequency pulses, and 10-20% signal deviations from theory are observed for common balanced steady-state free precession protocols. This discrepancy in the steady-state signal can be resolved by a simple T(2) substitution taking into account reduced transverse relaxation effects during finite radio-frequency excitation. However, finite radio-frequency effects may also affect the transient phase of balanced steady-state free precession, its contrast or its spin-echo nature and thereby have an adverse effect on common steady-state free precession magnetization preparation methods. As a result, an in-depth understanding of finite radio-frequency effects is not only of fundamental theoretical interest but also has direct practical implications. In this article, an analytical solution for balanced steady-state free precession with finite radio-frequency pulses is derived for the transient phase (under ideal conditions) and in the steady state demonstrating that balanced steady-state free precession key features are preserved but revealing an unexpected dependency of finite radio-frequency effects on relaxation times for the transient decay. Finally, the mathematical framework reveals that finite radio-frequency theory can be understood as a generalization of alternating repetition time and fluctuating equilibrium steady-state free precession sequence schemes.
Simple method to measure OSNR in transmission systems with channel filtering (2006)

A simple method to estimate the OSNR in transmission systems with strong channel filtering and spectral broadening is presented. The method uses the measured spectra from optical channel monitors at optical add-drop multiplexer and dynamic gain equaliser locations and requires no additional equipment.
Therapeutic Ultrasound, Part II*. High Intensity Focused Ultrasound: A Method of Hemostasis (2001)

Acoustic hemostasis is a new field of ultrasound research in which high intensity focused ultrasound (HIFU) is used to induce hemostasis in actively bleeding, injured solid organs and blood vessels. In animal studies, moderate to profuse bleeding from parenchymal and vascular injuries has been arrested within approximately 1 minute of HIFU application, even when a large dose of heparin was administered. Moreover, acoustic hemostasis has shown promise in cauterizing large regions of liver, providing a method for bloodless resectioning of abnormal tissue. Two distinct physical mechanisms of HIFU appear to contribute to hemostasis: (1) a thermal mechanism in which absorption of sound leads to temperature elevations, and (2) mechanical mechanisms (acoustic cavitation) in which gas and vapor‐filled voids oscillate with large displacement amplitudes. While the thermal mechanism results in a temperature increase in excess of 70°C in about 1 second, the mechanical mechanism appears to result in structural disruption of tissue and possible release of coagulation‐inducing tissue factors. Of utmost importance in further development of HIFU as a clinical tool is targeting and monitoring of the HIFU treatment. We have obtained initial success in integrating HIFU with ultrasound imaging so as to develop an image‐guided therapy system. Image‐guided acoustic hemostasis may provide a valuable method of hemostasis in surgical and prehospital settings with applications in trauma and elective surgery.