gebhart/patrepeval huggingface dataset:
Imaging metasurfaces based on graphene-loaded slot antennas (2020)

Spectral imagers, the classic example being the color camera, are ubiquitous in everyday life. However, most such imagers rely on filter arrays that absorb light outside each spectral channel, yielding ∼1/N efficiency for an N-channel imager. This is especially undesirable in thermal infrared (IR) wavelengths, where sensor detectivities are low. We propose an efficient and compact thermal infrared spectral imager comprising a metasurface composed of sub-wavelength-spaced, differently-tuned slot antennas coupled to photosensitive elements. Here, we demonstrate this idea using graphene, which features a photoresponse up to thermal IR wavelengths. The combined antenna resonances yield broadband absorption in the graphene exceeding the 1/N efficiency limit. We establish a circuit model for the antennas' optical properties and demonstrate consistency with full-wave simulations. We also theoretically demonstrate ∼58% free space-to-graphene photodetector coupling efficiency, averaged over the 1050 cm<sup>-1</sup> to 1700 cm<sup>-1</sup> wavenumber range, for a four-spectral-channel gold metasurface with a 0.883 µm by 6.0 µm antenna pitch. This research paves the way towards compact CMOS-integrable thermal IR spectral imagers.
Calyculin E and F, Novel Insecticidal Metabolites, from the Marine Sponge,Discodermiasp. (1991)

Journal Article Calyculin E and F, Novel Insecticidal Metabolites, from the Marine Sponge, Discodermia sp. Get access Akihiko Okada, Akihiko Okada Tsukuba Research Laboratory, Tsukuba Research Lab., Tokuyama Soda Co., Ltd., Kitahara 6, Tsukuba, Ibaraki 300–32, Japan Search for other works by this author on: Oxford Academic Google Scholar Keisuke Watanabe, Keisuke Watanabe Tsukuba Research Laboratory, Tsukuba Research Lab., Tokuyama Soda Co., Ltd., Kitahara 6, Tsukuba, Ibaraki 300–32, JapanAgricultural Science Research Laboratory, Takarazuka Research Center, Sumitomo Chemical Co., Ltd., Takatsukasa 4–2–1, Takarazuka, Hyogo 665, Japan To whom all correspondence should be addressed. Search for other works by this author on: Oxford Academic Google Scholar Kimitoshi Umeda, Kimitoshi Umeda Agricultural Science Research Laboratory, Takarazuka Research Center, Sumitomo Chemical Co., Ltd., Takatsukasa 4–2–1, Takarazuka, Hyogo 665, Japan Search for other works by this author on: Oxford Academic Google Scholar Masakazu Miyakado Masakazu Miyakado Agricultural Science Research Laboratory, Takarazuka Research Center, Sumitomo Chemical Co., Ltd., Takatsukasa 4–2–1, Takarazuka, Hyogo 665, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 55, Issue 11, 1 November 1991, Pages 2765–2771, https://doi.org/10.1080/00021369.1991.10871036 Published: 01 November 1991 Article history Received: 24 April 1991 Published: 01 November 1991
Five-port microwave receiver architectures and applications (2010)

Five-port architectures are investigated as direct conversion receivers for radio communications. Moreover, the five-port applications in different wireless and radio systems are explained. Using simulation and measurement studies, it is shown that the five-port architecture can be used as a low-cost, compact-size, and high-performance receiver in different radio systems.
Additive Manufacturing of Advanced High Temperature Masking Fixtures for EBPVD TBC Coating (2016)

The purpose of this Manufacturing Demonstration Facility (MDF) technical collaboration project between Praxair Surface Technologies, Inc. (PST) and Oak Ridge National Laboratory (ORNL) was to develop an additive manufacturing process to fabricate next generation high temperature masking fixtures for coating of turbine airfoils with ceramic Thermal Barrier Coatings (TBC) by the Electron Beam Physical Vapor Deposition (EBPVD) process. Typical masking fixtures are sophisticated designs and require complex part manipulation in order to achieve the desired coating distribution. Fixtures are typically fabricated from high temperature nickel (Ni) based superalloys. The fixtures are fabricated from conventional processes by welding of thin sheet material into a complex geometry, to decrease the weight load for the manipulator and to reduce the thermal mass of the fixture. Recent attempts have been made in order to fabricate the fixtures through casting, but thin walled sections are difficult to cast and have high scrap rates. This project focused on understanding the potential for fabricating high temperature Ni based superalloy fixtures through additive manufacturing. Two different deposition processes; electron beam melting (EBM) and laser powder bed fusion were evaluated to determine the ideal processing route of these materials. Two different high temperature materials were evaluated. The high temperature materials evaluated were Inconel 718 and another Ni base alloy, designated throughout the remainder of this document as Alloy X, as the alloy composition is sensitive. Inconel 718 is a more widely utilized material for additive manufacturing although it is not currently the material utilized for current fixtures. Alloy X is the alloy currently used for the fixtures, but is not a commercially available alloy for additive manufacturing. Praxair determined it was possible to build the fixture using laser powder bed technology from Inconel 718. ORNL fabricated the fixture geometry using the EBM technology in order to compare deposition features such as surface roughness, geometric accuracy, deposition rate, surface and subsurface porosity, and material quality. It was determined that the laser powder bed technology was ideal for the geometry and requirements of the fixture set by Praxair, and Praxair moved forward with the purchase of a laser powder bed system. The subsequent portion of the project focused on determining the ideal processing parameters for alloy X for the laser powder bed system using ORNL’s Renishaw laser powder bed system. Praxair supplied gas atomized powders of alloy X material with properties specified by ORNL. ORNL printed text cube arrays in order to determine the ideal combination of laser powder and laser travel speed in order to maximize material density, improve surface quality, and maintain geometric accuracy. Additional powder supplied by Praxair was used to fabricate a full-scale fixture component.
Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of β-tubulin (Asp26Glu) and less stable microtubules (2006)

Abstract Resistance to paclitaxel-based therapy is frequently encountered in the clinic. The mechanisms of intrinsic or acquired paclitaxel resistance are not well understood. We sought to characterize the resistance mechanisms that develop upon chronic exposure of a cancer cell line to paclitaxel in the presence of the P-glycoprotein reversal agent, CL-347099. The epidermoid tumor line KB-3-1 was exposed to increasing concentrations of paclitaxel and 5 μmol/L CL-347099 for up to 1 year. Cells grown in 15 nmol/L paclitaxel plus CL-347099 (KB-15-PTX/099) developed 18-fold resistance to paclitaxel and were dependent upon paclitaxel for maximal growth. They grew well and retained resistance to paclitaxel when grown in athymic mice. Cross-resistance (3- to 5-fold) was observed in tissue culture to docetaxel, the novel taxane MAC-321, and epothilone B. Collateral sensitivity (∼3-fold) was observed to the depolymerizing agents vinblastine, dolastatin-10, and HTI-286. KB-15-PTX/099–resistant cells did not overexpress P-glycoprotein nor did they have an alteration of [14C]paclitaxel accumulation compared with parental cells. However, a novel point mutation (T to A) resulting in Asp26 to glutamate substitution in class I (M40) β-tubulin was found. Based on an electron crystallography structure of Zn-stabilized tubulin sheets, the phenyl ring of C-3′ NHCO-C6H5 of paclitaxel makes contact with Asp26 of β-tubulin, suggesting a ligand-induced mutation. Optimized model complexes of paclitaxel, docetaxel, and MAC-321 in β-tubulin show a novel hydrogen bonding pattern for the glutamate mutant and rationalize the observed resistance profiles. However, a mutation in the paclitaxel binding pocket does not explain the phenotype completely. KB-15-PTX/099 cells have impaired microtubule stability as determined by a reduced percentage of tubulin in microtubules and reflected by less acetylated tubulin. These results suggest that a mutation in tubulin might affect microtubule stability as well as drug binding and contribute to the observed resistance profile. [Mol Cancer Ther 2006;5(2):270–8]
Sensibilización a diferentes ácaros en niños asmáticos atendidos en el Hospital Pediátrico Docente del Cerro. 2001 (2002)

Among the most frequently health problems found in our environment we have asthma and allergic rhinitis which have mites among the main etiological factors. In Cuba, the most frequently mites found in the house dust of asthmatic patients are: – Dermatophagoides pteronyssinus – Dermatophagoides siboney – Blomia tropicalis In order to determine specific IgE to mites found in the environment (D. pteronyssinus, D. farinae, D. microceras and B. tropicalis), using the Prick-Test and correlation between the title of the IgE with the Aguila de la Coba R. Sensibilizacion a diferentes acaros en ninos asmaticos Vol. 11, Num. 3 • Septiembre-Diciembre 2002 84 edigraphic.com :rop odarobale FDP VC ed AS, cidemihparG
Synthesis of New Poly(ethyleneglycol)s with a High Loading Capacity1 (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSynthesis of New Poly(ethyleneglycol)s with a High Loading Capacity1Maurizio Benaglia, Rita Annunziata, Mauro Cinquini, Franco Cozzi, and Stefano ResselView Author Information Centro C.N.R. and Dipartimento di Chimica Organica e Industriale, Universita' di Milano, via Golgi, 19-20133 Milano, Italy Cite this: J. Org. Chem. 1998, 63, 24, 8628–8629Publication Date (Web):November 10, 1998Publication History Received24 July 1998Published online10 November 1998Published inissue 1 November 1998https://pubs.acs.org/doi/10.1021/jo981451thttps://doi.org/10.1021/jo981451trapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views272Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alcohols,Anions,Chemical reactions,Functional groups,Polymers Get e-Alerts
Systematic profiling of HLA-C epitopes (2018)

Abstract Accurate predictive algorithms have required elucidation of HLA-peptide binding motifs from extensive HLA binding peptide ligand databases. Historically, however, little attention has been paid to HLA-C because of its perceived lower surface expression, even as newer studies have identified important HLA-C restricted viral epitopes. Robust predictive algorithms for HLA-C are thus lacking and yet, if improved, could markedly expand the spectrum of immune targets contributing to protective immune responses. We generated 21 distinct single HLA-C allele-expressing cell lines and subjected them to immunoaffinity purification and MS-based sequencing. From 33851 peptides identified from the 21 HLA-C expressing cell lines, we discovered novel anchor motifs. These data were used to train machine-learning algorithms to generate an accurate and novel HLA-C epitope prediction tool. Finally, we used our novel algorithm to predict HLA-C restricted neo-epitopes out of tumor biopsies.
Calculation and correction of piston phase aberration in synthesis imaging (2008)

The principle of redundant spacings calibration has previously been described for the purpose of calibrating piston phase aberration affecting elements of a dilute aperture array using a system of linear equations in terms of the aperture phases as well as object phase information. Here we develop matrices for the correction of piston phase aberration by use of image sharpness and also by phase retrieval. These are both presented in wavefront sensor formulation in order to draw analogy between the approaches. We then discuss solution ambiguity affecting both methods and describe array design criteria to prevent such ambiguity. The problem of increased image aliasing under image sharpness correction is also highlighted.
70 Gb/s Low-Power DC-Coupled NRZ Differential Electro-Absorption Modulator Driver in 55 nm SiGe BiCMOS (2019)

We present a 70 Gb/s capable optical transmitter consisting of a 50 μm long GeSi electro-absorption modulator (integrated in silicon photonics) and a fully differential driver designed in a 55 nm SiGe BiCMOS technology. By properly unbalancing the output stage, the driver can be dc-coupled to the modulator thus avoiding the use of on-chip or external bias-Ts. At a wavelength of 1560 nm, open eye diagrams for 70 Gb/s after transmission over 2 km standard single-mode fiber were demonstrated. The total power consumption is 61 mW, corresponding to 0.87 pJ/b at 70 Gb/s. Bit-error rate measurements at 50 Gb/s and 56 Gb/s (performed both back to back and with up to 2 km standard single-mode fiber) demonstrate large (0.4 UI at a BER of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> ) horizontal eye margins. This optical transmitter is ideally suited for datacenter applications that require densely integrated transceivers with a low power consumption.
Noiseless subsystems for collective rotation channels in quantum information theory (2004)

Collective rotation channels are a fundamental class of channels in quantum computing and quantum information theory. The commutant of the noise operators for such a channel is a C*-algebra which is equal to the set of fixed points for the channel. Finding the precise spatial structure of the commutant algebra for a set of noise operators associated with a channel is a core problem in quantum error prevention. We draw on methods of operator algebras, quantum mechanics and combinatorics to explicitly determine the structure of the commutant for the class of collective rotation channels.
Cell fusion mediated by interaction of a hybrid CD4.CD8 molecule with the human immunodeficiency virus type 1 envelope glycoprotein does occur after a long lag time (1993)

Several domains of CD4 have been suggested to play a critical role in events that follow its binding to the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (gp120-gp41). It has been reported previously that cells expressing a chimeric molecule consisting of the first 177 residues of human CD4 attached to residues from the hinge, transmembrane, and cytoplasmic domains of human CD8 did not form syncytia with HIV-1-infected cells (L. Poulin, L.A. Evans, S. Tang, A. Barboza, H. Legg, D.R. Littman, and J.A. Levy, J. Virol. 65: 4893-4901, 1991). In contrast, we found that the hybrid CD4.CD8 molecule expressed in human cells did render them susceptible to fusion with cells expressing HIV-1IIIB or HIV-1RF envelope glycoproteins encoded by vaccinia virus recombinants, but only after long lag times. The lag time of membrane fusion mediated by the hybrid CD4.CD8 molecule was fivefold longer than that for the wild-type CD4 molecule. However, the rate of binding to and the affinity of soluble gp120 for membrane-associated CD4.CD8 were the same as for CD4. Both molecules were laterally mobile, as determined by patching experiments. Coexpression of the CD4.CD8 chimera with wild-type CD4 did not lead to interference in fusion but had an additive effect. Therefore, the proximal membrane domains of CD4 play an important role in determining the kinetics of postbinding events leading to membrane fusion. We hypothesize that the long lag time is due to the inability of the CD4.CD8-gp120-gp41 complex to undergo the rapid conformational changes which occur during the fusion mediated by wild-type CD4.
Isotopically Selective Quantification by UPLC-MS of Aqueous Ammonia at Submicromolar Concentrations Using Dansyl Chloride Derivatization (2020)

Ammonia (NH₃) is essential for food production and is commercially synthesized from nitrogen (N₂) and hydrogen (H₂) using the Haber–Bosch process. Enormous amounts of ammonia are made every year in a reaction that requires high temperatures and pressures, with the Haber–Bosch accounting for ∼1.6% of total annual global energy consumption. Electrocatalysts are also being explored to convert in an environmentally friendly manner N₂ to NH₃ at ambient temperature and pressure.
DEVELOPMENT OF PRIMARY CMV-SPECIFIC T-CELL RESPONSES IN D+/R− TRANSPLANT RECIPIENTS DURING VALGANCICLOVIR PROPHYLAXIS (2010)

La Rosa, C.1; Limaye, A. P.2; Krishnan, A.1; Blumstein, G.1; Diamond, D. J.1 Author Information
Proteochemometric modeling reveals the interaction site for Trp9 modified α‐MSH peptides in melanocortin receptors (2007)

The interactions of alpha-MSH peptides with melanocortin receptors (MCRs) were located by proteochemometric modeling. Nine alpha-MSH peptide analogues were constructed by exchanging the Trp9 residue in the alpha-MSH core with the natural or artificial amino acids Arg, Asp, Cys, Gly, Leu, Nal, d-Nal, Pro, or d-Trp. The nine peptides created, and alpha-MSH itself, were evaluated for their interactions with the 4 wild-type MC(1,3-5)Rs and 15 multichimeric MCRs, each of the latter being constructed from three sequence segments, each taken from a different wild-type MC(1,3-5)R. The segments of the chimeric MCRs were selected according to the principles of statistical molecular design and were arranged so as to divide the receptors into five parts. By this approach, a set of 19 maximally diverse MC receptor proteins was obtained for which the interaction activity with the 10 peptides were measured by radioligand binding thus creating data for 190 ligand-protein pairs, which were subsequently analyzed by use of proteochemometric modeling. In proteochemometrics, the structural or physicochemical properties of both interaction partners, which represent the complementarity of the interacting entities, are used to create multivariate mathematical descriptions. (Here, physicochemical property descriptors of the receptors' and peptides' amino acids were used). A valid, highly predictive (Q2 = 0.74) and easily interpretable model was then obtained. The model was further validated by its ability to correctly predicting the affinity of alpha-MSH for new point and cassette-mutated MC4/MC1Rs, and it was then used to identify the receptor residues that are important for affording the high affinity and selectivity of alpha-MSH for the MC1R. It was revealed that these residues are located in several quite distant parts of the receptors' transmembrane cavity and must therefore cause their influence at various stages of the dynamic ligand-binding process, such as by affecting the conformation of the ligand at the vicinity of the receptor and taking part in the path of the ligand's entry into its binding pocket. Our study can be used as a template how to create high resolution proteochemometric models when there are a limited number of natural proteins and ligands available.
Terminologisation (1998)

The language of literary criticism and theory has become the ugliest private language in the world. Narratology has been one of the places where the most offensive terminology has taken hold, particularly in its structuralist and poststructuralist phases. Often the problem lies in a puerile overuse of abstract nouns like textuality, discursivity, narrativity, historicity, referentiality, intertextuality, supplementarity, iterability, synchronicity, subjectivity, specificity, directionality, positionality, contiguity, multiplicity, intentionality, plurality, structurality, intelligibility, heterogeneity, homogeneity, temporality, postmodernity, transverbality, linearity, specularity, canonicity, hypercanonicity and hyperreality. Then there are all those new processes invented by criticism which also become abstract nouns: focalisation, reification, problematisation, characterisation, naturalisation, defamiliarisation, totalisation, structuration, identification, interpellation, contextualisation, recontextualisation, acceleration, duration, actualisation and historicisation. Narratology in particular raided the terminology of linguistics and classical rhetoric for formal descriptors too numerous to list, some of which will feature in the argument of this chapter.
Pneumoperitoneum following endoscopic mucosal resection without perforation of the colon (2008)

In an otherwise healthy 39-year-old female patient with a family history of colon carcinoma, a sessile adenoma with low-grade intraepithelial neoplasia of approximately 2.5 cm was found in the cecum during screening colonoscopy. After indigo carmine staining the adenoma was lifted by submucosal injection of 8 mL normal saline containing epinephrine 1 : 100 000, and endoscopic mucosal resection (EMR) was performed using a standard polypectomy snare (l " Fig. The day after the procedure the patient developed generalized abdominal defense, and an abdominal radiography was performed showing a pneumoperitoneum (l " Fig. Because of a suspected perforation of the cecum the patient underwent explorative laparotomy and ileocecal resection the same day. Macroscopically, only a hematoma of the cecal wall was seen, and neither perforation of the cecum nor local peritonitis was observed intraoperatively, and thus primary anastomosis was performed. The patient was discharged in good health 5 days later. Histopathological analysis of the resectate revealed a defect at the site of mucosal resection down to the muscularis propria, with granulocytic infiltrates and a pneumatosis of the cecal wall (l " Fig.
Electrokinetic Microfluidic Systems (2005)

1. Asthma-drugs influence smooth muscle in both bronchi and lung vessels. Some vasodilation may be expected with isoprenaline and theophylline, whereas selective beta 2-stimulants seem to be without vascular effect. Isoprenaline relaxed to some extent 14 of 20 pulmonary artery strips after maximum contraction with carbacholine, acetylcholine and prostaglandin F2 alpha (Fig. 1b). Total reversibility occurred in only one specimen, the average relaxation of all specimens tested was 22 +/- 6%. 2. Eight of 10 specimens contracted with histamine, prostaglandin F2 alpha or serotonin were relaxed by theophylline (Fig. 1b), average relaxation was 37 +/- 25%. No statistically significant difference existed between relaxation induced with isoprenaline or theophylline.