gebhart/patrepeval huggingface dataset:
A surrogate modelling strategy to improve the surface morphology quality of inkjet printing applications (2023)

Current trends in manufacturing electronics feature digital inkjet printing as a key technology to enable the production of customised and microscale functional devices. However, electrical device performance depends on the accuracy and uniformity of the printed-track morphology, which presents significant quality challenges in current applications. Several studies to predict the morphology of printed features have been developed using computationally expensive physics-based simulations, but little attention has been paid to reduced order models suitable for fast production conditions. Here we propose a surrogate modelling framework to improve the inkjet-printed track morphology created by the sequential deposition of microdroplets on non-porous substrates. Assuming physical properties of a UV-curable dielectric ink made from tripropylene glycol diacrylate (TPGDA), a set of response surface equations built from a validated lattice Boltzmann simulation predict the track morphology as a function of drop spacing and contact angle hysteresis with an error percentage less than 10 %. Furthermore, the surrogate model is able to capture transient effects observed in experiments and builds track morphology in seconds, enabling efficient optimisation of printing and wetting parameters. The simplicity of the proposed technique makes it a promising tool for model driven inkjet printing process optimization, including real time process control and paves the way for better quality devices in the printed electronics industry.
Differential scanning calorimetry of albumin solders: Interspecies differences and fatty acid binding effects on protein denaturation (2000)

FAF albumin solders were found to denature at significantly lower temperatures, while also having a 30% reduction in enthalpy when compared with their FAC counterparts.
Pulsed Electric Field-Assisted Extraction of Juice from Food Plants (2004)

Solid-liquid extraction from food plants can be eﬀected by pressing (solid-liquid expression) or by solvent (diﬀusion, leaching). It has various industrial applications: Extraction of fruit juices and vegetable oils, production of sugar and wine, dewatering of ﬁbrous materials (fodder plants), dehydration of biological wastes, etc. (Brennan et al., 1990; Schwartzberg, 1997).
Design and self-assembly of DNA into nanoscale 3D shapes (2009)

We have developed a general method for solving a key challenge for nanotechnology: programmable self-assembly of complex, three-dimensional nanostructures [Douglas, Dietz, et al. 2009]. Previously, scaffolded DNA origami has been used to build arbitrary flat shapes 100 nm in diameter and almost twice the mass of a ribosome [Rothemund 2006]. Now we have succeeded in building custom three-dimensional structures that can be conceived as stacks of nearly flat layers of DNA. Successful extension from two dimensions to three dimensions in this way depended critically on calibration of folding conditions. A general capability for building complex, three-dimensional nanostructures will be of great interest to biologists, chemists, physicists, engineers, and computer scientists.
Ten-Year Outcomes of Selective Fusions for Adolescent Idiopathic Scoliosis (2019)

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Evaluation of the Potential Risk of Drugs to Induce Hepatotoxicity in Human—Relationships between Hepatic Steatosis Observed in Non-Clinical Toxicity Study and Hepatotoxicity in Humans- (2017)

In the development of drugs, we sometimes encounter fatty change of the hepatocytes (steatosis) which is not accompanied by degenerative change in the liver in non-clinical toxicity studies. In this study, we investigated the relationships between fatty change of the hepatocytes noted in non-clinical toxicity studies of compound X, a candidate compound in drug development, and mitochondrial dysfunction in order to estimate the potential risk of the compound to induce drug-induced liver injury (DILI) in humans. We conducted in vivo and in vitro exploratory studies for this purpose. In vivo lipidomics analysis was conducted to investigate the relationships between alteration of the hepatic lipids and mitochondrial dysfunction. In the liver of rats treated with compound X, triglycerides containing long-chain fatty acids, which are the main energy source of the mitochondria, accumulated. Accumulation of these triglycerides was considered to be related to the inhibition of mitochondrial respiration based on the results of in vitro mitochondria toxicity studies. In conclusion, fatty change of the hepatocytes (steatosis) in non-clinical toxicity studies of drug candidates can be regarded as a critical finding for the estimation of their potential risk to induce DILI in humans when the fatty change is induced by mitochondrial dysfunction.
Proteinases of common pathogenic bacteria degrade and inactivate the antibacterial peptide LL‐37 (2002)

Effectors of the innate immune system, the anti-bacterial peptides, have pivotal roles in preventing infection at epithelial surfaces. Here we show that proteinases of the significant human pathogens Pseudomonas aeruginosa, Enterococcus faecalis, Proteus mirabilis and Streptococcus pyogenes, degrade the antibacterial peptide LL-37. Analysis by mass spectrometry of fragments generated by P. aeruginosa elastase in vitro revealed that the initial cleavages occurred at Asn-Leu and Asp-Phe, followed by two breaks at Arg-Ile, thus inactivating the peptide. Proteinases of the other pathogens also degraded LL-37 as determined by SDS-PAGE. Ex vivo, P. aeruginosa elastase induced LL-37 degradation in human wound fluid, leading to enhanced bacterial survival. The degradation was blocked by the metalloproteinase inhibitors GM6001 and 1, 10-phenantroline (both of which inhibited P. aeruginosa elastase, P. mirabilis proteinase, and E. faecalis gelatinase), or the inhibitor E64 (which inhibited S. pyogenes cysteine proteinase). Additional experiments demonstrated that dermatan sulphate and disaccharides of the structure [DeltaUA(2S)-GalNAc(4,6S)], or sucroseoctasulphate, inhibited the degradation of LL-37. The results indicate that proteolytic degradation of LL-37 is a common virulence mechanism and that molecules which block this degradation could have therapeutic potential.
Model for the biogenesis of the spirobenzylisoquinoline alkaloids (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModel for the biogenesis of the spirobenzylisoquinoline alkaloidsMaurice Shamma and Charles David JonesCite this: J. Am. Chem. Soc. 1970, 92, 16, 4943–4949Publication Date (Print):August 1, 1970Publication History Published online1 May 2002Published inissue 1 August 1970https://pubs.acs.org/doi/10.1021/ja00719a030https://doi.org/10.1021/ja00719a030research-articleACS PublicationsRequest reuse permissionsArticle Views145Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dynamical Instability of a Doubly Quantized Vortex in a Bose-Einstein Condensate (2004)

Doubly quantized vortices were topologically imprinted in /F=1> 23Na condensates, and their time evolution was observed using a tomographic imaging technique. The decay into two singly quantized vortices was characterized and attributed to dynamical instability. The time scale of the splitting process was found to be longer at higher atom density.
Figure S3 from Paternally Expressed Gene 10 (PEG10) Promotes Growth, Invasion, and Survival of Bladder Cancer (2023)

&lt;p&gt;PEG10 triggers phosphorylation of Rb protein and promotes the proliferation of bladder cancer cells.&lt;/p&gt;
Thermomechanical behavior of BME capacitors during binder burnout (2001)

The deformation behavior of base-metal electrode-multilayer ceramic capacitors during binder burnout has been characterized using thermomechanical analysis, and the results have been compared to thermogravimetric analysis data.
LongSAGE profiling of nine human embryonic stem cell lines (2007)

To facilitate discovery of novel human embryonic stem cell (ESC) transcripts, we generated 2.5 million LongSAGE tags from 9 human ESC lines. Analysis of this data revealed that ESCs express proportionately more RNA binding proteins compared with terminally differentiated cells, and identified novel ESC transcripts, at least one of which may represent a marker of the pluripotent state.
Potentials, Limitations and Future Directions of MR Contrast Media in Ablation Therapies (2016)

MR contrast media have become an indispensable part of magnetic resonance (MR) imaging, but their roles in ablation therapies are still controversial. The interactions between physical/biological properties of MR contrast media.
Abstract 5719: Clinical response to the PDGFRα inhibitor avapritinib in high-grade glioma patients (2023)

Abstract PDGFRA has been shown to be commonly altered in high-grade gliomas (HGGs), including histone 3 lysine 27-mutated diffuse midline gliomas (H3K27M DMG), a disease with almost no long-term survivors. Here, we performed comprehensive genomic and transcriptomic analysis of 260 high-grade glioma cases, which revealed PDGFRA genomic alterations (mutations and/or amplifications) in 13% of patients. H3K27M DMGs had significantly higher PDGFRA expression compared to H3 wild-type tumors, and PDGFRA gene amplification resulted in even higher expression levels in H3K27M DMGs as well as H3 wild-type HGGs. We tested a panel of patient- derived pHGG/H3K27M DMG models against a range of PDGFRA inhibitors, including avapritinib, a potent small molecule inhibitor with relatively selective activity against both wild-type and mutant PDGFRA. Avapritinib showed supra-micromolar blood-brain barrier penetration in our pre-clinical models and demonstrated significant survival impact in an aggressive patient-derived H3K27M DMG mouse xenograft model. Finally, building on this preclinical activity, we report here the first clinical experience using avapritinib in eight pediatric and young adult patients with high-grade glioma (H3K27M DMG and/or PDGFRA altered). Avapritinib has thus far been well tolerated with no significant acute toxicities. Most importantly, our preliminary data reveal radiographic response evaluated by RAPNO criteria in 50% of patients, a striking outcome rarely seen in this patient population. In summary, we report that avapritinib is a selective, CNS-penetrant small molecule inhibitor of PDGFRA that shows potent activity in preclinical models and produces promising clinical responses with good tolerability in patients with high-grade glioma. This suggests a promising role for avapritinib therapy in this population with previously dismal outcomes. Citation Format: Lisa Mayr, Maria Trissal, Kallen Schwark, Jenna Labelle, Andrew Groves, Julia Furtner-Srajer, Jeffrey Supko, Liesa Weiler-Wichtl, Olivia Hack, Jacob Rozowsky, Joana G. Marques, Eshini Pandatharatna, Ulrike Leiss, Verena Rosenmayr, Frank Dubois, Noah F. Greenwald, Sibylle Madlener, Armin S. Guntner, Hana Pálová, Natalia Stepien, Daniela Lötsch-Gojo, Christian Dorfer, Karin Dieckmann, Andreas Peyrl, Amedeo A. Azizi, Alicia Baumgartner, Ondřej Slabý, Petra Pokorná, Pratiti Bandopadhayay, Rameen Beroukhim, Keith Ligon, Christof Kramm, Annika Bronsema, Simon Bailey, Ana Guerreiro Stücklin, Sabine Mueller, David T. Jones, Natalie Jäger, Jaroslav Štěrba, Leonhard Müllauer, Christine Haberler, Chandan Kumar-Sinha, Arul Chinnaiyan, Rajen Mody, Mary Skrypek, Nina Martinez, Daniel C. Bowers, Carl Koschmann, Johannes Gojo, Mariella Filbin. Clinical response to the PDGFRα inhibitor avapritinib in high-grade glioma patients. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5719.
Manufacture of Powder Coatings by Spraying of Gas-Enriched Melts (2001)

An alternative process for the manufacture of powder coatings was developed. The continuously operated process is applicable to new (low-melting and fast-reacting) and conventional powder coating systems and allows to produce coatings with improved properties. The process uses the solubility of compressed gases in melts of coating polymers at pressures up to 220 bar. The single components of a powder coating mixture are melted in separated tanks and are dosed to a static mixer by means of high-pressure pumps. In the mixer the melts are homogenized and simultaneously compressed carbon dioxide is dissolved. The so-formed solution is depressurized directly afterwards over a nozzle into a spray tower. Thereby, the melt is atomized into fine droplets and cooled by the expanding gas. The droplets reach the solidification point of the melt and fine solid particles are formed. The particle size, particle size distribution and the morphology of the powders could be adjusted by the operating parameters of the plant.
Solid-state optical properties of linear polyconjugated molecules: π-stack contra herringbone (2005)

The intermolecular arrangement in the solid state and the consequences on the optical and photophysical properties are studied on different derivatives of oligophenylenevinylenes by UV/VIS absorption and angular-resolved polarized fluorescence spectroscopy. Unsubstituted distyrylbenzene (DSB) organizes in a herringbone manner, with the long axes of the molecules oriented in parallel, but the short axes almost perpendicular to each other. Fluorinated distyrylbenzene (F(12)DSB) as well as the DSB:F(12)DSB cocrystals prefer cofacial pi-stacking in the solid state. For all structures, the consequence of the parallel alignment of the transition moments is a strongly blueshifted H-type absorption spectrum and a low radiative rate constant k(F). Significant differences are observed for the emission spectra: the perpendicular arrangement of the short axes in DSB crystals leads to only very weak intermolecular vibronic coupling. Hence the emission spectrum is well structured, very similar to the one in solution. For F(12)DSB and DSB:F(12)DSB, the cofacial arrangement of the adjacent molecules enables strong intermolecular vibronic coupling of adjacent molecules. Thus, an unstructured and strongly redshifted excimerlike emission spectrum is observed. The differences in the electronic nature of the excited states are highlighted by quantum-chemical calculations, revealing the contribution of interchain excitations to the electronic transitions.
A smart model HD DVD/DVD/CD compatible pickup head (2006)

We have proposed a compatible pickup for HD DVD/DVD/CD systems, which uses a blue/red/IR multi beam laser unit and a single sensor unit. The optical path of the DVD system is aligned to that of the HD DVD system to share one sensor area. Experimental results confirm the practicality of the proposed pickup.
Time Reversal in Subwavelength-Scaled Resonant Media: Beating the Diffraction Limit (2011)

Time reversal is a physical concept that can focus waves both spatially and temporally regardless of the complexity of the propagation medium. Time reversal mirrors have been demonstrated first in acoustics, then with electromagnetic waves, and are being intensively studied in many fields ranging from underwater communications to sensing. In this paper, we will review the principles of time reversal and in particular its ability to focus waves in complex media. We will show that this focusing effect depends on the complexity of the propagation medium rather than on the time reversal mirror itself. A modal approach will be utilized to explain the physical mechanism underlying the concept. A particular focus will be given on the possibility to break the diffraction barrier from the far field using time reversal. We will show that finite size media made out of coupled subwavelength resonators support modes which can radiate efficiently in the far field spatial information of the near field of a source. We will show through various examples that such a process, due to reversibility, permits to beat the diffraction limit using far field time reversal, and especially that this result occurs owing to the broadband inherent nature of time reversal.
On the spatial correlation in shallow water and its impact on networking protocols (2012)

In this paper, we study the spatial correlation of the communications performance in a static scenario, by using the SPACE08 experimental data set. Specifically we estimate the channel quality in terms of Signal to Interference and Noise Ratio (SINR) at the output of the equalizer, at four receiving stations, which were deployed at different distances and orientations, and we compute their cross correlation both in time and in space. This experimental study on the spatial distribution of the channel quality among nodes allows us to provide insight on the performance of networking protocols. As an example, we consider three routing policies, which we compare in terms of throughput, latency and link utilization. Results show that the policy that minimizes the number of hops is optimal in this scenario.
Laser assisted photocatalytic reduction of metal ions by graphene oxide (2011)

This work provides a new approach for the solution processable synthesis of metal–graphene oxide nanocomposites in aqueous solutions at ambient conditions. Using 532 nm laser or tungsten lamp irradiation of a mixture of graphene oxide (GO) and metal ions derived from HAuCl4 or AgNO3 we report the photocatalytic reduction of the metal ions simultaneously with partial reduction of GO, and the synthesis of metal–graphene nanocomposites. The gold and silver ions are reduced following the laser or the tungsten lamp irradiation of GO for a few minutes in water–ethanol, water–polyethylene glycol (PEG) or pure water solvents. The reduction of GO in the presence of ethanol or PEG is much faster than in pure water under identical experimental conditions. This is attributed to the role of ethanol or PEG in scavenging the holes generated by the irradiation of GO thus leaving the photogenerated electrons to reduce GO. In pure water in the presence of gold ions, partial reduction of GO occurs due to the efficient capturing of the photogenerated electrons in GO by the gold ions and the strong absorption of the 532 nm photons by the newly formed Au nanoparticles. Strong photothermal effects are observed leading to a significant increase in the temperature of the solution and suggesting that metal–graphene nanocomposites could be promising materials for the efficient conversion of solar energy into usable heat for a variety of thermal, thermochemical and thermomechanical applications.
Single Carrier Transmission for URLLC with Adaptive Radio Resource Utilization (2019)

Next generation of wireless communication systems is expected to support a wide set of applications and use cases. Among these, applications with ultra-reliable and low-latency communications (URLLC) are at utmost importance due to stringent requirements. In this work, single carrier (SC) transmission is considered as a promising solution to meet demands of systems with URLLC. Firstly, SC system parameters affecting reliability and latency are comprehensively explained. Additionally, these parameters are optimized in time and frequency domain to achieve URLLC. Later, adaptive roll-off factor usage within a SC block is proposed to provide more efficient resource utilization. Trade-offs between reliability, latency and system efficiency are shown via computer based simulations. SC transmission inherently offers flexible structure to optimize the trade-offs through proper parameter selection.
A Dempster-ShaferModel for Document Retrieval using Noun Phrases (1998)

In this paper, we propose a document retrieval system based on natural language processing of documents and queries. We use single terms and term groups as indexing elements to represent documents and queries. The model is formally expressed within the Dempster-Shafer Theory of Evidence. We discuss in detail how we use this theory to represent a document collection, indexing elements, documents and queries. The retrieval function is derived directly from the underlying theory. We then present an implementation of the model. The experimental work carried out is reported last.
Optimizing strategies for face classification in the detection of acromegaly (2013)

Introduction: It has been shown that face classification software might help distinguishing between subjects with and without acromegaly on regular photographs. In this project we investigated several aspects that will be necessary and helpful to bring this recognition method closer to clinical application.
Upper bounds on the size of quantum codes (1999)

This paper is concerned with bounds for quantum error-correcting codes. Using the quantum MacWilliams (1972, 1977) identities, we generalize the linear programming approach from classical coding theory to the quantum case. Using this approach, we obtain Singleton-type, Hamming-type, and the first linear-programming-type bounds for quantum codes. Using the special structure of linear quantum codes, we derive an upper bound that is better than both Hamming and the first linear programming bounds on some subinterval of rates.
Planar optical 3-D multistage interconnection networks (1997)

We have been developed the planar optical approach[1-3] in order to implement multistage interconnection networks (MIN) on a single glass block. Planar integrated optics composed of free-space optical components integrated on a glass block makes signal connections between 2-dimensional (2-D) arrays of input and output optoelectronic devices via 3-D glass space. Cascading operation in the optical multistage interconnections is based on the combination of signal beam array and clock beam array at the node stages[4], however, it has remained as one of the challenges to be solved to the planar integrated optics.