gebhart/patrepeval huggingface dataset:
Anomaly detection via distributed sensing: a VAR modeling approach (2021)

In modern manufacturing, each stage of industrial processes is accurately measured via multiple sensors and, consequently, a large amount of data is made available for analytics, monitoring and control purposes. A possible use of such data is to detect anomalies in order to prevent potential damages and hazards. In this paper, we will consider a sensor setup returning distributed time series measurements that can be used for failure identification. In particular, an anomaly detection strategy based on Vector Autoregressive (VAR) modeling for multivariate time series will be presented and analyzed in detail. The effectiveness of the proposed methodology will be assessed on experimental data from a real industrial case study.
Coplanar non-resonant elements for multiband operation (2013)

The great demand of multifunction wireless devices or smartphones capable of providing large number of functionalities forces the antenna engineers to develop miniature antennas able to operate in multiple communication standards. In addition, the device thickness is continuously shrinking, thus forcing the need of developing low height structures. This paper proposes the integration of two coplanar non-resonant elements capable of solving size and height limitations. The solution is integrated in a ground plane having typical smartphone dimensions of 120 mm × 50 mm and attains hepta-band operation covering eight communication standards (GSM850, GSM900, GSM1800, GSM1900, UMTS, LTE2100, LTE2300, and LTE2500) by means of two non-resonant elements featured by reduced dimensions of just 6 mm × 6 mm. The paper further extends the proposal to a radiating system capable of providing nona-band operation for covering ten communication standards by integrating two additional non-resonant elements of reduced dimensions, 6 mm × 12 mm and 3 mm × 3 mm, intended for providing operation in two additional communication standards, namely LTE700 and GPS.
A regularized Newton solver for linear model predictive control (2018)

We investigate direct numerical solvers in linear model predictive control, where the prediction model is given by linear systems subject to linear inequality constraints on the state and the input, and the performance index is convex and quadratic. The inequality constraints are treated by the primal-dual interior-point method. We propose a novel direct solver based on the augmented Lagrangian regularization of a reduced Hessian. The new solver has the same arithmetic complexity as the factorized Riccati recursion. The direct solver can be implemented in terms of BLAS3 matrix operations.
Toward reliable retrieval of functional information of papillary dermis using spatially resolved diffuse reflectance spectroscopy (2016)

Spatially resolved diffuse reflectance spectroscopy (SRDRS) has been employed to quantify tissue optical properties and its interrogation volume is majorly controlled by the source-to-detector separations (SDSs). To noninvasively quantify properties of dermis, a SRDRS setup that includes SDS shorter than 1 mm is required. It will be demonstrated in this study that Monte Carlo simulations employing the Henyey-Greenstein phase function cannot always precisely predict experimentally measured diffuse reflectance at such short SDSs, and we speculated this could be caused by the non-negligible backward light scattering at short SDSs that cannot be properly modeled by the Henyey-Greenstein phase function. To accurately recover the optical properties and functional information of dermis using SRDRS, we proposed the use of the modified two-layer (MTL) geometry. Monte Carlo simulations and phantom experiment results revealed that the MTL probing geometry was capable of faithfully recovering the optical properties of upper dermis. The capability of the MTL geometry in probing the upper dermis properties was further verified through a swine study, and it was found that the measurement results were reasonably linked to histological findings. Finally, the MTL probe was utilized to study psoriatic lesions. Our results showed that the MTL probe was sensitive to the physiological condition of tissue volumes within the papillary dermis and could be used in studying the physiology of psoriasis.
The In Vitro and In Vivo Activity of the Microtubule Disruptor STX140 Is Mediated by Hif-1 Alpha and CAIX Expression. (2015)

Tumor neo-angiogenesis is regulated, in part, by the hypoxia-inducible gene HIF1. Evidence suggests HIF1 associates with polymerized microtubules and traffics to the nucleus. This study investigated the role of HIF1 in mediating the antitumor activity of two steroid-based sulfamate ester microtubule disruptors, STX140 and STX243, in vitro and in vivo. The effects of STX140, STX243 and the parental compound 2-methoxyestradiol (STX66) on HIF1α and HIF2α protein expression were assessed in vitro in MCF-7 and MDA-MB-231 cells cultured under hypoxia. More pertinently, their effects were examined on HIF1-regulated genes in vivo in mice bearing MCF-7 or MDA-MB-231 tumors. The level of mRNA expression of vascular endothelial growth factor (VEGF), glucose transporter 1 (GLUTI), phosphoglycerate kinase (PGK), ATP-binding cassette sub-family B member 1 (ABCB1) and carbonic anhydrase IX (CAIX) was quantified by Real-time Polymerase Chain Reaction (RT-PCR). Despite inhibiting nuclear HIF1α protein accumulation under hypoxia in vitro, STX140 and STX243 did not significantly regulate the expression of four out of five HIF1α-regulated genes in vitro and in vivo. Only CAIX mRNA expression was down-regulated both in vitro and in vivo. Immunoblot analysis showed that STX140 and STX243 reduced CAIX protein expression in vitro. These compounds had no effect on HIF2α translocation. The potential for inhibition of CAIX by STX140 and STX243 was examined by docking the ligands to the active site in comparison with a known sulfamate-based inhibitor. Microtubule disruption and antitumor activity of STX140 and STX243 is most likely HIF1-independent and may, at least in part, be mediated by inhibition of CAIX expression and activity.
Automatic Acquisition of Context Models and its Application to Video Surveillance (2006)

This paper addresses the problem of automatically acquiring context models from data. Context and human behavior are represented using a state model, called situation model. This model consists of different layers referring to entities, filters, roles, relations, situation and situation relationship. We propose a framework for the automatic acquisition of these different layers. In particular, this paper proposes a novel generic situation acquisition algorithm. The algorithm is also successfully applied to a video surveillance task and is evaluated by the public CAVIAR video database. The results are encouraging.
Dynamic restart policies (2002)

We describe theoretical results and empirical study of context-sensitive restart policies for randomized search procedures. The methods generalize previous results on optimal restart policies by exploiting dynamically updated beliefs about the probability distribution for run time. Rather than assuming complete knowledge or zero knowledge about the run-time distribution, we formulate restart policies that consider real-time observations about properties of instances and the solver's activity. We describe background work on the application of Bayesian methods to build predictive models for run time, introduce an optimal policy for dynamic restarts that considers predictions about run time, and perform a comparative Study of traditional fixed versus dynamic restart policies.
Performance evaluation of the FACSCount system: A dedicated system for clinical cellular analysis (1996)

Flow cytometers are instruments that can determine multiparameter data simultaneously and have a great potential in providing unique information about cells. The FACSCount System is designed as the first dedicated flow cytometer for the clinical laboratory. Its current configuration provides CD4, CD8, and CD3 absolute counts from 100 microliters of whole blood. Adapting the FACSCount System to the clinical setting are minimal sample handling, lysis free cell preparation, automated fluorescence gating, built-in calibrated reference beads, and appropriate error code reporting. Quality control checks ensure that reported CD4 counts, important for clinical follow-up and patient management, are accurate, precise, and reproducible across instruments over time.
Protective Effects of Ethanol Extract Mixtures of Sophora flavescens, Glycyrrhiza uralensis and Dictamnus dasycarpus against Oxidative Stress-induced Damage in C2C12 Murine Myoblasts (2017)

Objectives : Increased oxidative stress by reactive oxygen species (ROS) has been suggested as a major cause of muscle fatigue. Although several studies have demonstrated the various biological properties of Sophora flavescens Aiton, Glycyrrhiza uralensis Fischer and Dictamnus dasycarpus Turcz, but the antioxidative potentials have not been clearly demonstrated. The present study was designed to investigate the protective effects of their water and ethanol extract mixtures (medicinal herbal mixtures, MHMIXs) on hydrogen peroxide (<TEX>$H_2O_2$</TEX>)-induced cell damage and apoptosis in C2C12 myoblasts. Methods : Cytotoxicity was assessed by an MTT assay. Quantitative evaluation of apoptosis induction and ROS production was evaluated by flow cytometry analysis. Expression levels of apoptosis regulatory and DNA-damage proteins were detected by Western blotting. Result : The inhibition of <TEX>$H_2O_2$</TEX>-induced cell proliferation was effectively blocked in extracts of 3: 1: 1 (EMHMIXs-1) or 2: 2: 1 (EMHMIXs-2) of S. flavescens, G. uralensis and D. dasycarpus Turcz, ethanol extracts from various complex extracts in C2C12 myoblasts. EMHMIXs-1 and EMHMIXs-2 also effectively attenuated <TEX>$H_2O_2$</TEX>-induced C2C12 cell apoptosis, which was associated with the restoration of the upregulation of Bad and death receptor 4, and downregulation of XIAP and cIAP-1 induced by <TEX>$H_2O_2$</TEX>. In addition, these herbal mixtures significantly blocked the <TEX>$H_2O_2$</TEX>-induced ROS generation and phosphorylation of <TEX>$p-{\gamma}H2A.X$</TEX>, which suggests that they can prevent <TEX>$H_2O_2$</TEX>-induced cellular DNA damage. Conclusions : The results suggest that EMHMIXs-1 and EMHMIXs-2 could block the DAN damage and apoptosis of C2C12 myoblasts by oxidative stress through blocking ROS generation.
Guidelines for the Design of Computers and Information Processing Systems to Increase Their Access by Persons with Disabilities. Version 2.0. (1986)

Many low-cost and no-cost modifications to computers would greatly increase the number of disabled individuals who could use standard computers without requiring custom modifications, and would increase the ability to attach special input and output systems. The purpose of the Guidelines is to provide an awareness of these access problems and a focal point for listing possible solutions. Section 1 provides an overview of disability types and the major impacts that each disability has on computer use. Section II contains a listing of problem areas and possible solutions, arranged by the part of the computer involved, including operating systems, keyboards, display screens, other output devices, mechanical design, and documentation. The Executive Summary contains a chart summarizing the problems, the populations affected, a relative priority, possible solution strategies, and the impact/benefit of such adaptations or modifications on/to the mass market for the computer. A summary listing of design ideas is presented in three categories: design features to increase the number of people who can use an unmodified computer; design features to facilitate the connection of special accessories or programs needed by more severely involved persons; and to design features to facilitate the use of computers as special devices, such as portable communication aids. (JDD) *********************************************************************** Reproductions supplied by EDRS are the best that can be made from the original docuvent. ***********************************************************************
Iron kinetics following treatment with sucroferric oxyhydroxide or ferric citrate in healthy rats and models of anaemia, iron overload or inflammation (2020)

Iron uptake was higher from FC versus SFOH following a single dose in anaemia, iron overload and inflammation rat models and 13 weeks of treatment in normal rats. These observations likely relate to different physicochemical properties of SFOH and FC and suggest distinct mechanisms of iron absorption from these two phosphate binders.
Kinetic Analysis of the Actinorhodin Aromatic Polyketide Synthase (1999)

Type II polyketide synthases (PKSs) are bacterial multienzyme systems that catalyze the biosynthesis of a broad range of natural products. A core set of subunits, consisting of a ketosynthase, a chain length factor, an acyl carrier protein (ACP) and possibly a malonyl CoA:ACP transacylase (MAT) forms a "minimal" PKS. They generate a poly-beta-ketone backbone of a specified length from malonyl-CoA derived building blocks. Here we (a) report on the kinetic properties of the actinorhodin minimal PKS, and (b) present further data in support of the requirement of the MAT. Kinetic analysis showed that the apoACP is a competitive inhibitor of minimal PKS activity, demonstrating the importance of protein-protein interactions between the polypeptide moiety of the ACP and the remainder of the minimal PKS. In further support of the requirement of MAT for PKS activity, two new findings are presented. First, we observe hyperbolic dependence of PKS activity on MAT concentration, saturating at very low amounts (half-maximal rate at 19.7 +/- 5.1 nM). Since MAT can support PKS activity at less than 1/100 the typical concentration of the ACP and ketosynthase/chain length factor components, it is difficult to rule out the presence of trace quantities of MAT in a PKS reaction mixture. Second, an S97A mutant was constructed at the nucleophilic active site of the MAT. Not only can this mutant protein support PKS activity, it is also covalently labeled by [(14)C]malonyl-CoA, demonstrating that the serine nucleophile (which has been the target of PMSF inhibition in earlier studies) is dispensible for MAT activity in a Type II PKS system.
Cardiovascular complications in pituitary gigantism (results of an international study) (2018)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
ChemInform Abstract: Enantioselective 1,4‐Addition of Aliphatic Grignard Reagents to Enones Catalyzed by Readily Available Copper(I) Thiolates Derived from TADDOL. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Lynch Syndrome Screening Strategies Among Newly Diagnosed Endometrial Cancer Patients (2009)

: III.
Determining snow depth using Ku-band interferometric synthetic aperture radar (InSAR) (2014)

Monitoring seasonal snow accumulation is important for evaluation of snow models, for short- and long-term snow cover monitoring, and for both military and civilian activities in cold climates. Improved spatial analysis of snow depth and volume can help decision makers plan for future events and mitigate risk. Current snow depth measurement methods fall short of operational requirements. This research explored a new approach for determining snow depth using Ku-band multi-pass (monostatic) airborne interferometric synthetic aperture radar (InSAR). A perturbation method that isolated and compared high frequency terrain phase to elevation was used to generate Snow-Off and Snow-On DEMs from the InSAR phase data. Differencing the InSAR DEMs determined elevation change caused by accumulated snow. Comparison of InSAR snow depths to manual snow depth measurements indicated average InSAR snow depth errors of -8cm, 95cm, -49cm, 176cm, 87cm, and 42cm for six SAR pairs. The source of these errors appears to be mostly related to uncorrected slope and tilt in fitted low frequency planes. Results show that this technique has promise but accuracy could be substantially improved by the use of bistatic SAR systems, which would allow for more stable and measurable interferometric baselines.
Comparison of operation microscope and exoscope in ear surgery (2021)

Introduction Beside operation microscopes and endoscopes, exoscopes are available for ear surgery and are intended to offer a two-handed workflow with enhanced ergonomics. In this study, the use of operation microscopes during different ear surgeries is compared to an exoscope.
Human insulin receptor radioimmunoassay: applicability to insulin-resistant states (1989)

A radioimmunoassay of the human insulin receptor was developed employing a potent rabbit polyclonal antibody to the human insulin receptor and a highly purified human placental insulin receptor preparation. The receptor, obtained by sequential affinity chromatography with insulin receptor monoclonal antibody-agarose and wheat germ agglutinin-agarose, was radiolabeled with 125I-Bolton-Hunter reagent at specific activities of 2,100-3,300 Ci/mmol. Over 75% of this ligand was immunoprecipitable with the polyclonal antireceptor antibody and remained immunoprecipitable for greater than 45 days. The assay was sensitive to unlabeled receptor concentrations as low as 0.2 ng/0.5 ml; unlabeled insulin did not cross-react and unlabeled insulin-like growth factor (IGF)-I receptor cross-reacted weakly. The radioimmunoassay was applicable to the measurement of insulin receptors in tissues and cells that were extracted by solubilization in 1% Triton X-100; no purification of the extracted receptor was necessary. Of the three major target tissues for insulin action studied, liver had the highest concentration of receptors (47.6 ng/mg protein); fat and muscle had lower levels. Other studies with the radioimmunoassay indicated that insulin receptors were decreased both in monocytes from obese hyperinsulinemic subjects and in fibroblasts from patients with leprechaunism.
Gene cloning, expression, crystallization and preliminary X-ray analysis ofThermus thermophilusarginyl-tRNA synthetase (2001)

The gene encoding the highly thermostable arginyl-tRNA synthetase (ArgRS) from Thermus thermophilus was cloned and overexpressed in Escherichia coli under the control of the T7 promoter. The recombinant ArgRS was purified by two chromatographic steps and was crystallized by the hanging-drop vapour-diffusion method using PEG 8000 and ethylene glycol as precipitants. The crystals belong to the hexagonal space group P6(5), with unit-cell parameters a = b = 156.04 (7), c = 87.17 (4) A. X-ray data to 2.8 A resolution were collected at room temperature from a native crystal using an in-house X-ray source. Uranium, platinum and selenomethionine derivatives were found to be useful for phasing by the multiple isomorphous replacement method with anomalous scattering. The flash-frozen crystals diffracted beyond 2.3 A resolution using synchrotron radiation from the beamline 41XU at SPring-8 (Harima).
Gene Discovery and Product Development for Grain Quality Traits (1999)

The composition of oils, proteins, and carbohydrates in seeds of corn, soybean, and other crops has been modified to produce grains with enhanced value. Both plant breeding and molecular technologies have been used to produce plants carrying the desired traits. Genomics-based strategies for gene discovery, coupled with high-throughput transformation processes and miniaturized, automated analytical and functionality assays, have accelerated the identification of product candidates. Molecular marker-based breeding strategies have been used to accelerate the process of moving trait genes into high-yielding germplasm for commercialization. These products are being tested for applications in food, feed, and industrial markets.
Varied DNA Polymerase—Substrate Interactions in the Nucleotide Binding Pocket (2002)

Replication fidelity: How do DNA polymerases ensure selectivity? Further insights into interactions between a DNA polymerase and the sugar moiety of the template nucleotide were gained through functional enzyme studies, which employed site-specifically modified DNA substrates (see scheme). The results suggest that steric hindrance by the sugar moiety of incoming nucleotide triphosphates primarily plays an important role.
Abortive replication and reactivationin vitrorespiratory syncytial virus (RSV) infection in palivizumab-treated HeLa cells (2016)

<b>Introduction:</b> Abortive RSV replication occurs in <i>in vitro</i> cell lines and animal models in presence of the monoclonal antibody Palivizumab. Naturally present RSV antibodies are known to wane giving rise to the possibility of reactivation of viral replication. <b>Aims:</b> The study was to determine whether latent RSV might be reactivated in a cell culture model by Palivizumab removal. <b>Methods:</b> HeLa cells at 80% confluency were infected with fluorescent-tagged RSV (MOI: 0.003-3) and cultured in the presence of Palivizumab (400-6400ug/ml). Appearance of fluorescent indicates production of a fluorescent protein and is a marker of replication. Culture medium was replenished every five days (with or without fresh Palivizumab). The fluorescence emitted intracellularly by RSV virions was tracked and analysed by the Incucyte® Zoom System (Essen BioScience). <b>Results:</b> Uninfected HeLa cells had minimal fluorescence (long dashed line), whereas HeLa+RSV MOI 0.03 had maximum fluorescence at 100-hour culture (solid line). Fluorescence was lower (p&lt;0.05) in HeLa+RSV continuously cultured with Palivizumab (short dashed-line) compared to those without Palivizumab (dotted line) from 228-hours of culture onwards (*). <b>Conclusions:</b> This data indicates that RSV replication reactivation occurs after RSV antibodies are removed from the system and this may be relevant disease susceptibility in humans.
Role of montmorillonite for enhancing fire retardancy of intumescent PLA (2014)

This work deals with the effect of an organomodified montmorillonite (OMMT, cloisite C30B) in intumescent PLA, which makes it nonflammable. The use of OMMT dramatically improves the fire properties of intumescent PLA in terms of limiting oxygen index (LOI) and heat release rate (HRR), which is almost zero. The part played by OMMT in the improvement of the FR performance was studied using a Microscale Combustion Calorimeter (MCC), solid-state NMR (13C, 31P and 27Al) and specific set-up for temperature and swelling measurements in the char during fire test. It is shown that the clay increases the efficiency of the protective char by strongly limiting heat and mass transfer.