gebhart/patrepeval huggingface dataset:
Mitotic spindle studied using picosecond laser scissors (2006)

In previous studies we have shown that the second harmonic 532 nm, from a picosecond frequency doubled Nd:YAG laser, can cleanly and selectively disrupt spindle fiber microtubules in live cells (Botvinick et al 2004, Biophys. J. 87:4303-4212). In the present study we have ablated different locations and amounts of the metaphase mitotic spindle, and followed the cells in order to observe the fate of the irradiated spindle and the ability of the cell to continue through mitosis. Cells of the rat kangaroo line (PTK2) were stably transfected by ECFP-tubulin and, using fluorescent microscopy and the automated RoboLase microscope, (Botvinick and Berns, 2005, Micros. Res. Tech. 68:65-74) brightly fluorescent individual cells in metaphase were irradiated with 0.2447 nJ/micropulse corresponding to an irradiance of 1.4496*10^7 J/(ps*cm^2) . Upon irradiation the exposed part of the mitotic spindle immediately lost fluorescence and the following events were observed in the cells over time: (1) immediate contraction of the spindle pole towards the cut, (2) recovery of connection between pole and cut microtubule, (3) completion of mitosis. This system should be very useful in studying internal cellular dynamics of the mitotic spindle.
The Forkhead factor FoxQ1 influences epithelial differentiation (2010)

The Forkhead family of transcription factors comprises numerous members and is implicated in various cellular functions, including cell growth, apoptosis, migration, and differentiation. In this study, we identified the Forkhead factor FoxQ1 as increased in expression during TGF-β1 induced changes in epithelial differentiation, suggesting functional roles of FoxQ1 for epithelial plasticity. The repression of FoxQ1 in mammary epithelial cells led to a change in cell morphology characterized by an increase in cell size, pronounced cell-cell contacts, and an increased expression of several junction proteins (e.g., E-cadherin). In addition, FoxQ1 knock-down cells revealed rearrangements in the actin-cytoskeleton and slowed down cell cycle G1-phase progression. Furthermore, repression of FoxQ1 enhanced the migratory capacity of coherent mammary epithelial cells. Gene expression profiling of NM18 cells indicated that FoxQ1 is a relevant downstream mediator of TGF-β1-induced gene expression changes. This included the differential expression of transcription factors involved in epithelial plasticity, for example, Ets-1, Zeb1, and Zeb2. In summary, this study has elucidated the functional impact of FoxQ1 on epithelial differentiation.
An inequality for rational functions with applications to some statistical estimation problems (1991)

The well-known Baum-Eagon inequality (1967) provides an effective iterative scheme for finding a local maximum for homogeneous polynomials with positive coefficients over a domain of probability values. However, in many applications the goal is to maximize a general rational function. In view of this, the Baum-Eagon inequality is extended to rational functions. Some of the applications of this inequality to statistical estimation problems are briefly described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Table 1 from Acquired Resistance with Epigenetic Alterations Under Long-Term Antiangiogenic Therapy for Hepatocellular Carcinoma (2023)

&lt;p&gt;Primers&lt;/p&gt;
A modified rider optimization algorithm for multihop routing in WSN (2020)

Abstract Wireless Sensor Networks (WSNs) have an important role in establishing the communication between the Internet of things (IoT) devices. Routing is an important research field in the WSN as it helps in finding the suitable paths for the communication. This paper proposes a multipath routing algorithm based on the optimization approach. The proposed routing algorithm has two important phases, namely, Cluster head selection and multipath routing. Initially, the cluster head selection is carried out by the kernel based Fuzzy C Means (kernel FCM) algorithm. Then, the multipath routing is established by the newly developed Rider Salp Swarm Optimization algorithm (RSSA), which is the integration of the Rider Optimization Algorithm (ROA) and Salp Swarm Algorithm (SSA). The fitness function of the proposed RSSA is designed by considering the several factors, such as energy, QoS and trust. The simulation of the proposed work is carried out using different WSN setups, and the results are compared with several comparative techniques. From the results, it can be summarized that the proposed RSSA based multipath routing has better performance with values of 0.2526, 0.0764, 0.5, and 26 for delay, energy, throughput and number of alive nodes, respectively.
Supplementary Figure 16 from Sensitive Detection of Minimal Residual Disease in Patients Treated for Early-Stage Breast Cancer (2023)

&lt;p&gt;Affect of mutation abundance in tumor biopsy on MRD detection in early stage breast cancer cohort. (A) Allele fraction histogram of all tracked mutaions and whether they were detected or not. (B) Cancer cell fraction distribution of all tracked mutations and whether they were detected or not.&lt;/p&gt;
Automated noise estimation in polarization-sensitive optical coherence tomography (2020)

Advanced signal reconstruction in polarization-sensitive optical coherence tomography (OCT) frequently relies on an accurate determination of the signal noise floor. However, current methods for evaluating the noise floor are often impractical and subjective. Here we present a method using the degree of polarization uniformity and known speckle intensity statistics to model and estimate the OCT noise floor automatically. We establish the working principle of our method with a series of phantom experiments and demonstrate the robustness of our noise estimation method across different imaging systems and applications in vivo.
A 400 mV 160 nW/Ch Compact Energy Efficient $\Delta \Sigma$ Modulator for Multichannel Biopotential Signal Acquisition System (2021)

Analog to digitalconverter circuit design for biomedical systems with multiple recording channels presents challenges in high density and very low power consumption. Passive integrator and loop-filter based delta-sigma modulators (DSMs) have been recently reported for ultra-low-power and highly energy-efficient data converters for multi-channel biopotential acquisition. However, these modulators rely on a very high oversampling ratio (OSR) to achieve the target resolution. Higher OSR leads to higher power consumption in the modulator and the digital low-pass and decimation filter succeeding the DSM. We present a low OSR passive integrator-based DSM in this work by relying on a duty-cycled resistor (DCR). DCR enables the realization of large time constants in the already passive loop-filter, with minimal area and overhead power consumption. This leads to design of DSMs that are highly area, power and energy-efficient, suitable for multi-channel biopotential recording systems. We demonstrate a second order, duty-cycled passive integrator based CTDSM in a 65 nm CMOS technology for a 10 kHz biopotential bandwidth. Measurement results show that the fabricated design achieves an SNDR/DR of 56.36/63.1 dB while consuming only 160 nW power with an OSR of 32 and occupies an area of 0.035 mm <sup>2</sup> with a state-of-the-art energy efficiency of 14.9 fJ/conv. In-vitro and in-vivo measurements are provided to further demonstrate the operation of the proposed DSM.
Line-plane broadcasting in a data communications network of a parallel computer (2023)

Methods, apparatus, and products are disclosed for line-plane broadcasting in a data communications network of a parallel computer, the parallel computer comprising a plurality of compute nodes connected together through the network, the network optimized for point to point data communications and characterized by at least a first dimension, a second dimension, and a third dimension, that include: initiating, by a broadcasting compute node, a broadcast operation, including sending a message to all of the compute nodes along an axis of the first dimension for the network; sending, by each compute node along the axis of the first dimension, the message to all of the compute nodes along an axis of the second dimension for the network; and sending, by each compute node along the axis of the second dimension, the message to all of the compute nodes along an axis of the third dimension for the network.
Tumor COX-2 expression and prognosis of patients with resectable pancreatic cancer (2007)

Tumor COX-2 expression portends a poor prognosis for patients with resected adenocarcinoma of the pancreas, particularly in tumors > or =3 cm.
Tribromomesitylene structure at 14 K methyl conformation and tunneling (1999)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation F. Boudjada, J. Meinnel, A. Cousson, W. Paulus, M. Mani, M. Sanquer; Tribromomesitylene structure at 14 K methyl conformation and tunnelling. AIP Conf. Proc. 15 June 1999; 479 (1): 217–222. https://doi.org/10.1063/1.59469 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
A multi-site, international laboratory study to assess the performance of penicillin susceptibility testing of Staphylococcus aureus (2023)

The EUCAST method with a P1 disc resulted in a lower VME rate compared with the CLSI methods with a P10 disc. These results should be considered in the context that among collections of PSSA isolates, as determined by automated MIC testing, less than 10% harbour blaZ. Furthermore, the clinical relevance of phenotypically susceptible, but blaZ-positive S. aureus, remains unclear.
GBAS with RAIM Based on the Constrained GLRT for Precision Landing Using Galileo and GPS (2007)

Global navigation satellite systems have made an important&#13;\nimprovement since the first utilization for military purposes.&#13;\nOne of the civil application domains that profit the&#13;\nmost of this technology is the civil aviation. It is also the&#13;\nmost challenging application due to the high level of safety&#13;\nrequired. One of the most stringent required parameter is&#13;\nthe integrity of the position provided by the system and to&#13;\nfulfill this requirement, additional algorithms at system and&#13;\nat user level are necessary to provide robust information to&#13;\nthe pilot. At the system level, the American Wide Area&#13;\nAugmentation System (WAAS) is the first augmented system&#13;\nthat has been proposed to support civil aviation phases&#13;\nof flight. Unfortunately the availability of this system can&#13;\nprovide only Approach with Vertical guidance I (APV I)&#13;\nrequirements. At the user level, the consistency check algorithms&#13;\nfor monitoring the integrity have been developed.&#13;\nThese algorithms are known as Receiver Autonomous&#13;\nIntegrity Monitoring (RAIM) algorithms. Conventional&#13;\n"snapshot" RAIM Fault Detection/Exclusion (FDE) algorithms&#13;\nbased on least squares method consider epoch by&#13;\nepoch to check pseudo-ranges. Another approach considers&#13;\nthe use of previous epochs to augment the number of&#13;\nobservations and thus information. These algorithms are&#13;\ncalled sequential RAIM. Snapshot and sequential RAIM&#13;\nFDE based on the constrained Generalized Likelihood Ratio&#13;\nTest (GLRT) have shown very promising results for&#13;\nsingle and dual frequency absolute positioning receivers.&#13;\nPrevious studies have demonstrated under certain circumstances&#13;\nthat such a RAIMcould fulfill requirements of APV&#13;\nI. In this paper the detection/exclusion functions availability&#13;\nfor three different RAIM FDE algorithms applied to the&#13;\ndifferential GPS and Galileo modes is discussed and some&#13;\nvery preliminary results of simulation are shown.
Impact of a Narrow Coastal Bay of Bengal Sea Surface Temperature Front on an Indian Summer Monsoon Simulation (2018)

A dry bias in climatological Central Indian rainfall plagues Indian summer monsoon (ISM) simulations in multiple generations of climate models. Here, using observations and regional climate modeling, we focus on a warm coastal Bay of Bengal sea surface temperature (SST) front and its impact on Central Indian rainfall. The SST front, featuring sharp gradients as large as 0.5 °C/100 km, is colocated with a mixed layer depth (MLD) front, in a region where salinity variations are known to control MLD. Regional climate simulations coupling a regional atmospheric model with an ocean mixed layer model are performed. A simulation with observed MLD climatology reproduces SST, rainfall, and atmospheric circulation associated with ISM reasonably well; it also eliminates the dry bias over Central India significantly. Perturbing MLD structure in the simulations, we isolate the SST front's impact on the simulated ISM climate state. This experiment offers insights into ISM climatological biases in the coupled NCEP Climate Forecast System version-2. We suggest that the warm SST front is essential to Central Indian rainfall as it helps to sustain deep and intense convection in its vicinity, which may be a source for the vortex cores seeding the monsoon low-pressure systems.
X-Ray Transmittance Modeling-Based Material Decomposition Using a Photon-Counting Detector CT System (2020)

Recently developed x-ray transmittance modeling-based three-step algorithm compensates for the spectral distortion in the photon-counting detector (PCD) and estimates the line-integrals of the basis materials. The x-ray transmittance modeling linearizes the nonlinear forward imaging model and derives a computationally efficient three-step algorithm that achieves almost unbiased and minimum variance estimator. In this article, we apply the algorithm to the experimental data from a research whole-body PCD-computed tomography (CT) system. We perform pixel-by-pixel calibration using water-equivalent phantoms to fit the output of the scanner to the forward model and then feed the calibrated data into the three-step algorithm. Experimental data from iodine phantom and swine abdomen scans demonstrate that the proposed algorithm compensates for the spectral distortion effectively and estimates the line-integrals of two basis materials, water and iodine, efficiently. The proposed method substantially reduces the beam hardening and ring artifacts present in the test phantom compared to those of the image-based material decomposition method and the images directly reconstructed from the raw data of the system. The algorithm also exhibits less bias and comparable noise to those of the other methods for various x-ray energies.
Transfer of Iron-Dextran Across the Placenta (1975)

In pregnant mice. 55Fe-labeled iron-dextran (Imferon) is transferred across the placenta. It was detected in the bone marrow, liver, spleen and peripheral blood of the pregnant animal, as well as in the embryonic liver erythroid precursors and peripheral blood. Uptake by liver and peripheral blood cells of pregnant anemic mice and by liver erythroid precursors of anemic embryos was significantly higher than in normal control animals. Electron-microscopic examination revealed that the iron deposits in the embryonic liver erythroid precursors had the same structure as the injected Imferon.
The First Intermolecular Transition Metal Catalyzed [5 + 2] Cycloadditions with Simple, Unactivated Vinylcyclopropanes (2002)

Abstract For Abstract see ChemInform Abstract in Full Text.
Macronodular Adrenal Hyperplasia due to Mutations in an Armadillo Repeat Containing 5 (ARMC5) Gene: A Clinical and Genetic Investigation (2014)

ARMC5 mutations are implicated in clinically severe Cushing's syndrome associated with MAH. Knowledge of a patient's ARMC5 status has important clinical implications for the diagnosis of Cushing's syndrome and genetic counseling of patients and their families.
Selection rules for the photoionization of diatomic molecules (1990)

In the photoionization of the diatomic molecule AB to yield AB++e− the photoelectron may be charatcterized by a partial wave expansion in terms of its orbital angular momentum quantum number l. For a given value of l, conservation of angular momentum implies that transitions can only occur for ΔJ=l+ (3)/(2) , l+ (1)/(2) , ... ,−l− (1)/(2) , −l− (3)/(2) , where ΔJ=J+−J is the change (half-integer) in the total angular momentum (excluding nuclear spin) of the AB+ ion rovibronic level and the AB neutral rovibronic level. Other selection rules are ΔΩ=−λ+ (3)/(2) , −λ+ (1)/(2) , ... , −λ− (3)/(2) , and ΔM=−ml+ (3)/(2) , −ml+ (1)/(2) , ... , −ml− (3)/(2) . In addition, for Hund’s case (a) and case (b) coupling, ΔS=S+−S=± (1)/(2) , ΔΣ=± (1)/(2) , and ΔΛ=−λ, −λ±1. Parity selection rules have been derived for transitions connecting levels described by one of the four coupling schemes, Hund’s case (a), case (b), case (c), and case (d). In particular, for a case (a)–case (a) transition, ΔJ−ΔS+Δp+Δs+l=odd, where the symbols have their traditional spectroscopic meanings. The parity label p=0,1 has been associated with the e, f label, from which it may be shown that (e/f )↔(e/f ) for ΔJ− (1)/(2) +l=odd and (e/f )↔( f/e) for ΔJ− (1)/(2) +l=even. It also follows that ±↔± for l odd and ±↔∓for l even. Moreover, Σ± is connected to Σ± in general, but Σ± is only connected to Σ∓ for l≥2 and λ=±1 (π wave). For homonuclear diatomics, the additional selection rules are (g/u)↔(g/u) for l=odd, (g/u)↔(u/g) for l=even, and (s/a)↔(s/a) but (s/a)↔/(a/s).
Living Polymerization of (o-(Trimethylsilyl)phenyl)acetylene Using "Small Alkoxide" Molybdenum(VI) Initiators (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLiving Polymerization of (o-(Trimethylsilyl)phenyl)acetylene Using "Small Alkoxide" Molybdenum(VI) InitiatorsRichard R. Schrock, Shifang Luo, Nadia C. Zanetti, and Harold H. FoxCite this: Organometallics 1994, 13, 9, 3396–3398Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://doi.org/10.1021/om00021a008Request reuse permissionsArticle Views287Altmetric-Citations87LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (348 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
"Meta-atomless" architecture based on an irregular continuous fabric of coupling-tuned identical nanopillars enables highly efficient and achromatic metasurfaces (2020)

Metasurfaces are subwavelength-thick constructs, consisting of discrete meta-atoms, providing discretized levels of phase accumulation that collectively approximate a designed optical functionality. The meta-atoms utilizing the Pancharatnam-Berry phase with polarization-converting structures produced encouraging implementations of optical components including metalenses. However, to date, a pending and fundamental problem of this approach has been the low device efficiency that such resulting metasurface components suffer, an unwanted side effect of large lattice constants that are used for preventing intercoupling of their meta-atoms. Although the use of near-field coupling for tuning electromagnetic resonances found its use in constructing efficient narrow-band designs, such structures fell short of providing high efficiency over a broad spectrum. Here, we propose and show that tightly packed fabrics of identical dielectric nanopillar waveguides with continuously tuned intercoupling distances make excellent and complete achromatic metasurface elements. This architecture enables the scatterers to interact with the incoming wave extremely efficiently. As a proof-of-concept demonstration, we showed an achromatic cylindrical metalens, constructed from strongly coupled dielectric nanopillars of a single geometry as continuously set phase elements in a meta-atomless fashion, working in the entirety of the 400-700 nm band. This metalens achieves over 85% focusing efficiency across this whole spectral range. To combat polarization sensitivity, we used hexagonally stacked nanopillars to build up a polarization-independent scatterer library. Finally, a circular metalens with polarization-independent operation and achromatic focusing was obtained. This is a paradigm shift in making an achromatic metasurface architecture by weaving identical nanopillars coupled into an irregular lattice laterally constructed via carefully tuned near-field coupling.
Measurement ofbhadron production fractions in 7 TeVppcollisions (2012)

Measurements of b hadron production ratios in proton-proton collisions at a center-of-mass energy of 7 TeV with an integrated luminosity of 3 pb 1 are presented. We study the ratios of strange B meson to light B meson production
Specialized Proresolving Mediators Enhance Human B Cell Differentiation to Antibody-Secreting Cells (2012)

The resolution of inflammation is an active and dynamic process critical in maintaining homeostasis. Newly identified lipid mediators have been recognized as key players during the resolution phase. These specialized proresolving mediators (SPM) constitute separate families that include lipoxins, resolvins, protectins, and maresins, each derived from essential polyunsaturated fatty acids. New results demonstrate that SPM regulate aspects of the immune response, including reduction of neutrophil infiltration, decreased T cell cytokine production, and stimulation of macrophage phagocytic activity. The actions of SPM on B lymphocytes remain unknown. Our study shows that the novel SPM 17-hydroxydosahexaenoic acid (17-HDHA), resolvin D1, and protectin D1 are present in the spleen. Interestingly, 17-HDHA and resolvin D1, but not protectin D1, strongly increase activated human B cell IgM and IgG production. Furthermore, increased Ab production by 17-HDHA is due to augmented B cell differentiation toward a CD27(+)CD38(+) Ab-secreting cell phenotype. The 17-HDHA did not affect proliferation and was nontoxic to cells. Increase of plasma cell differentiation and Ab production supports the involvement of SPM during the late stages of inflammation and pathogen clearance. The present study provides new evidence for SPM activity in the humoral response. These new findings highlight the potential applications of SPM as endogenous and nontoxic adjuvants, and as anti-inflammatory therapeutic molecules.