gebhart/patrepeval huggingface dataset:
Efficient Resonance Management in Ultrahigh‐Q 1D Photonic Crystal Nanocavities Fabricated on 300 mm SOI CMOS Platform (2020)

Abstract Photonic crystal (PhC) nanocavities have demonstrated unique capabilities in terms of light confinement and manipulation. As such, they are becoming attractive for developing novel resonance‐based photonic integrated circuits (PICs). Here two essential challenges arise however—how to realize ultrahigh quality factor ( Q ) PhC cavities using standard fabrication processes compatible with large volume fabrication, and how to efficiently integrate them with existing building blocks. In this work, ultrahigh‐ Q one‐dimensional (1D) PhC nanocavities fabricated on a 300 mm silicon‐on‐insulator wafer are demonstrated by optical lithography, with a record Q factor of up to 0.84 million. Moreover, efficient mode management in those cavities is shown by coupling them with an access waveguide, realizing two critical components: notch filters and narrow‐band reflectors. In particular, they allow both single‐wavelength and multi‐wavelength operation, at the desired resonant wavelengths, over a broad wavelength range (&gt;100 nm). Compared to traditional cavities, this offers a fantastic strategy for implementing resonances precisely in PIC designs with more freedom in terms of wavelength selectivity and the control of mode number. Given their compatibility with optical lithography and compact footprint, the realized 1D PhC nanocavities will be of profound significance for designing compact and novel resonance‐based photonic components on large scale.
An embedded point-of-care malaria screening device for low-resource regions(Conference Presentation) (2016)

In this article we propose a point-of-care screening device for the detection and identification of malaria parasite, plasmodium vivax, plasmodium malaria, plasmodium oval and plasmodium falciparum with a time frame of 15-20 minute. In our device we can provide 97-98% sensitivity for each species as we are using traditional staining methods for detecting the parasites. In addition, as we are also quantifying the parasites, it is possible to provide an accurate estimate about the malarial stage of the patient. The image processing approach increases the total numbers of samples screened by reducing interventions of trained pathologists. This helps in reducing the delays in screening process arising from increased number of potential cases based on seasonal and local variations. The same reduces mortality rate by faster diagnosis and reduced false negative detections (i.e. increased sensitivity). The system can also be integrated with telemedicine platform to obtain inputs from medical practitioners at tertiary healthcare units for diagnostic decision making. Through this paper, we present the functional prototype of this device containing all the integrated parts. The prototype incorporates image acquisition, image processing, storage, multimedia transmission and reporting environment for a low cost PDA device. It is a portable device capable of scanning slides. The acquired image will be preprocessed and processed to get desired output. The device is capable of transmitting and storing pathological information to database placed in a distant pathological center for further consultation.
Detection Of Glottal Closing And Opening Instants Using An Improved Dypsa Framework (2009)

Publication in the conference proceedings of EUSIPCO, Glasgow, Scotland, 2009
Parallel proximal support vector machine for high-dimensional pattern classification (2012)

Proximal support vector machine (PSVM) is a simple but effective classifier, especially for solving large-scale data classification problems. An inherent deficiency of PSVM lies on its inefficiency for dealing with high-dimensional data. In this paper, we propose a parallel version of PSVM (PPSVM). Based on random dimensionality partitioning, PPSVM can obtain partitioned local model parameters in parallel, with combined parameters to form the final global solution. In fact, PPSVM enjoys two properties: 1) It can calculate model parameters in parallel and is therefore a fast learning method with theoretically proved convergence; and 2) It can avoid the inversion of large matrix, which makes it suitable for high-dimensional data. In the paper, we also propose a random PPSVM with randomly partitioned data in each iteration to improve the performance of PSVM. Experimental results on real-world data demonstrate that the proposed methods can obtain similar or even better prediction accuracy than PSVM with much better runtime efficiency.
The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression (2018)

AXL is activated by its ligand GAS6 and is expressed in triple-negative breast cancer cells. In the current study, we report AXL expression in HER2-positive (HER2<sup>+</sup>) breast cancers where it correlates with poor patient survival. Using murine models of HER2<sup>+</sup> breast cancer, Axl, but not its ligand Gas6, was found to be essential for metastasis. We determined that AXL is required for intravasation, extravasation, and growth at the metastatic site. We found that AXL is expressed in HER2<sup>+</sup> cancers displaying epithelial-to-mesenchymal transition (EMT) signatures where it contributes to sustain EMT. Interfering with AXL in a patient-derived xenograft (PDX) impaired transforming growth factor β (TGF-β)-induced cell invasion. Last, pharmacological inhibition of AXL specifically decreased the metastatic burden of mice developing HER2<sup>+</sup> breast cancer. Our data identify AXL as a potential anti-metastatic co-therapeutic target for the treatment of HER2<sup>+</sup> breast cancers.
δ Ca2+/Calmodulin‐Dependent Protein Kinase IIIsozyme‐Specific Induction of Neurite Outgrowth in P19 Embryonal Carcinoma Cells (2000)

Ca(2+)/calmodulin-dependent protein kinase II (CaMK-II) has been linked to the induction of differentiation in preneuronal cells. In these cells, delta isozymes represent the majority of CaMK-IIs expressed and are activated by differentiation stimuli. To determine whether delta CaMK-IIs are causative or coincident with in vitro differentiation, we overexpressed wild-type, constitutively active, and C-terminal domains of delta and gamma CaMK-II isozymes in mouse P19 and NIH/3T3 cells using high-efficiency transfections. At 1-2 days after transfection, only constitutively active delta CaMK-II isozymes induced branched cellular extensions in both cell types. In P19 cells, retinoic acid induced neurite extensions after 3-4 days; these extensions were coincident with a fourfold increase in endogenous CaMK-II activity. Extensions induced by both retinoic acid and delta CaMK-IIs contained class III beta-tubulin in a discontinuous or beaded pattern. C-terminal CaMK-II constructs disrupted the ability of endogenous CaMK-II to autophosphorylate and blocked retinoic acid-induced differentiation. delta CaMK-II was found along extensions, whereas gamma CaMK-II exhibited a more diffuse, cytosolic localization. These data not only support an extranuclear role for CaMK-II in promoting neurite outgrowth, but also demonstrate CaMK-II isozyme specificity in these early steps of neuronal differentiation.
Applications of SPB (2012)

The purpose of this chapter is to summarize the cardinal points of each application. Shortest Path Bridging (SPB) is unique at this moment in terms of offering the Metro Ethernet Forum (MEF) connectivity constructs directly in the infrastructure data plane. Traditional enterprise data center designs are based on a simple switching hierarchy, of which typically only the first two layers are layer 2 switches; above that, traffic is funneled into a tree of routers. The Radio Access Networks (RAN) for “4G” wireless extends significantly the requirements on the backhaul technology over previous generations, and it can also benefit from the properties of SPBM. Controlled Vocabulary Terms radio access networks
Learned Optimizers that Scale and Generalize (2017)

Learning to learn has emerged as an important direction for achieving artificial intelligence. Two of the primary barriers to its adoption are an inability to scale to larger problems and a limited ability to generalize to new tasks. We introduce a learned gradient descent optimizer that generalizes well to new tasks, and which has significantly reduced memory and computation overhead. We achieve this by introducing a novel hierarchical RNN architecture, with minimal per-parameter overhead, augmented with additional architectural features that mirror the known structure of optimization tasks. We also develop a meta-training ensemble of small, diverse optimization tasks capturing common properties of loss landscapes. The optimizer learns to outperform RMSProp/ADAM on problems in this corpus. More importantly, it performs comparably or better when applied to small convolutional neural networks, despite seeing no neural networks in its meta-training set. Finally, it generalizes to train Inception V3 and ResNet V2 architectures on the ImageNet dataset for thousands of steps, optimization problems that are of a vastly different scale than those it was trained on. We release an open source implementation of the meta-training algorithm.
Spin-transfer-torque switching in a spin-valve nanopillar with a conically magnetized free layer (2015)

Spin-transfer-torque switching in a spin-valve nanopillar with a conically magnetized free layer (c-FL) was theoretically studied using the macrospin model. The c-FL is shown to have advantages such as a low switching current density and short switching time compared with a perpendicularly magnetized free layer (p-FL). A c-FL with a thermal stability of 60kBT exhibited a switching current density 22% smaller and a switching time 56% shorter than those of a p-FL with the same thermal stability.
A METHOD FOR THE CORRECT PROTECTION RESPONSE DURING POWER SYSTEM FAULTS SUBJECTED TO THE BAUCH'S PARADOX PHENOMENON (2015)

False tripping is frequently blamed on incorrect settings or poor system models. However in many cases, it may be attributed to not uncommon phenomena, such as the so called “Bauch’s paradox”. In this paper the physical background of the Bauch’s paradox phenomena will be explained. Based on this, a method for the correct response of distance protection under these extreme conditions is presented. Amongst others, this method consists of: the detection of the Bauch’s paradox phenomena, optimised loop selection logic and a modified directional element. Chosen events recorded during distance protection test are used to illustrate the effectiveness of this method.
Serum IgM level as predictor of symptomatic hyperviscosity in patients with Waldenström macroglobulinaemia (2017)

Symptomatic hyperviscosity is a common clinical manifestation in patients with Waldenström macroglobulinaemia (WM) and high serum IgM levels. Prompt intervention is required to prevent catastrophic events, such as retinal or central nervous system bleeding. Identifying patients at high risk of symptomatic hyperviscosity might support the decision to treat asymptomatic patients before irreversible damage occurs. We carried out a large retrospective study in 825 newly diagnosed WM patients, of who 113 (14%) developed symptomatic hyperviscosity. The median serum IgM level at the time of symptomatic hyperviscosity was 61·8 g/l (range 31-124 g/l). Forty-four patients (36%) had symptomatic hyperviscosity at the time of WM diagnosis. A serum IgM level >60 g/l at diagnosis was associated with a median time to symptomatic hyperviscosity of 3 months, whereas the median time for patients with serum IgM level of 50·01-60 g/l was approximately 3 years. Adjusting for other clinical factors, the odds of developing symptomatic hyperviscosity were 370-fold higher with serum IgM levels >60 g/l, and showed an association with CXCR4 mutational status. Symptomatic hyperviscosity did not impact overall survival (P = 0·12). The findings support the use of serum IgM level >60 g/l as a criterion for initiation of therapy in an otherwise asymptomatic WM patient.
Comparative Evaluation of the Efficacy of Polyethylene Glycol With Ascorbic Acid and an Oral Sulfate Solution in a Split Method for Bowel Preparation: A Randomized, Multicenter Phase III Clinical Trial (2017)

Oral sulfate solution is effective at colonoscopy cleansing and has acceptable tolerability when it is compared with polyethylene glycol with ascorbic acid. The taste and flavor of oral sulfate solution still need to be improved to enhance tolerability.
The advantages of vacuum deposition as a technique to grow PPV-oligomer/C60 thin films for organic solar cell applications (2000)

Organic solar cells based on the concept of the donor-acceptor bulk heterojunction have been critically evaluated. Spincast organic layers of the PPV-pentamer 2,5-di-n-octyloxy-1,4-bis(4',4-bisstyryl)styryl-benzene (Ooct-OPV5) and C 60 were investigated to reveal the shortcomings of this deposition technique. Spectral response measurements on ITO/Ooct-OPV5:C 60 /Al devices, illuminated IV curves of ITO/Ooct-OPV5:PS:C 60 /Al devices and the characteristics of FETs based on Ooct-OPV5 pointed out that the following aspects of the organic heterojunction need drastic improvement: layer thickness, structural order and reproducibility. The advantages of vacuum deposition as a technique to solve these problems are discussed.
Hierarchical modeling and speed control of networked induction motor systems (2013)

This paper proposes a hierarchical modeling method and a fuzzy speed control strategy for nonlinear networked induction motor systems subject to network induced time delay and packets dropout. The networked induction motor control system consists of a networked speed controller and a local controller. Fuzzy gain scheduling is applied on the networked speed controller to guarantee the robustness against complicated variations on the communication network. The state predictor is to compensate the time delay occurred in data transmission in the feedback channel. In stability analysis, the upper allowed limits of the time delay and packets dropout are calculated using the Lyapunov-Krasovskii theorem, respectively. Simulation and experimental results are given to illustrate the effectiveness of the proposed approach.
Direct Biochemical Evidence for the Utilization of UDP-bacillosamine by PglC, an Essential Glycosyl-1-phosphate Transferase in the Campylobacter jejuni N-Linked Glycosylation Pathway (2006)

Campylobacter jejuni has a general N-linked glycosylation pathway, encoded by the pgl gene cluster. In C. jejuni, a heptasaccharide is transferred from an undecaprenyl pyrophosphate donor [GalNAc-alpha1,4-GalNAc-alpha1,4-(Glcbeta1,3)-GalNAc-alpha1,4-GalNAc-alpha1,4-GalNAc-alpha1,3-Bac-alpha1-PP-undecaprenyl, where Bac is bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose)] to the asparagine side chain of target proteins at the Asn-X-Ser/Thr motif. In this study, we have cloned, overexpressed in Escherichia coli, and purified PglC, the glycosyl-1-phosphate transferase responsible for the first step in the biosynthesis of the undecaprenyl-linked heptasaccharide donor. In addition, we report the first synthetic route to uridine 5'-diphosphobacillosamine. Using the uridine 5'-diphosphobacillosamine and undecaprenyl phosphate, we demonstrate the ability of PglC to produce undecaprenyl pyrophosphate bacillosamine using radiolabeled HPLC and mass spectral analysis. In addition, we revealed that PglC does not accept uridine 5'-diphospho-N-acetylglucosamine or uridine 5'-diphospho-N-acetylgalactosamine as substrates but will accept uridine 5'-diphospho-6-hydroxybacillosamine, an analogue of bacillosamine that retains the C-6 hydroxyl functionality from the biosynthetic precursor. The in vitro characterization of PglC as a bacillosamine 1-phosphoryl transferase provides direct evidence for the early steps in the C. jejuni N-linked glycosylation pathway, and the coupling of PglC with the latter glycosyltransferases (PglA, PglJ, PglH, and PglI) allows for the "one-pot" chemoenzymatic synthesis of the undecaprenyl pyrophosphate heptasaccharide donor.
SUV39H1/DNMT3A‐dependent methylation of the RB1 promoter stimulates PIN1 expression and melanoma development (2018)

Melanoma is among the most aggressive and treatment-resistant human cancers. Aberrant histone H3 methylation at Lys 9 (H3K9) correlates with carcinogenic gene silencing, but the significance of suppressor of variegation 3-9 homolog 1 (SUV39H1), an H3K9-specific methyltransferase, in melanoma initiation and progression remains unclear. Here, we show that SUV39H1-mediated H3K9 trimethylation facilitates retinoblastoma ( RB) 1 promoter CpG island methylation by interacting with DNA methyltransferase 3A and decreasing RB mRNA and protein in melanoma cells. Reduced RB abundance, in turn, impairs E2F1 transcriptional inhibition, leading to increased peptidyl-prolyl cis-trans isomerase never-in-mitosis A (NIMA)-interacting 1 (PIN1) levels, human keratinocyte neoplastic cell transformation, and melanoma tumorigenesis via enhanced rapidly accelerated fibrosarcoma 1(RAF1)-MEK-ERK signaling pathway activation. In a synergistic model with B16-F1 murine melanoma cells, SUV39H1 and PIN1 overexpression increased melanoma growth, which was abrogated by their inhibition in SUV39H1-overexpressing B16-F1 mice. SUV39H1 also positively correlated with PIN1 expression in human melanoma. Our studies establish SUV39H1 as an oncogene in melanoma and underscore the role of chromatin factors in regulating tumorigenesis.-Kim, G., Kim, J.-Y., Lim, S.-C., Lee, K. Y., Kim, O., Choi, H. S. SUV39H1/DNMT3A-dependent methylation of the RB1 promoter stimulates PIN1 expression and melanoma development.
Performance evaluation of an adaptive backoff scheme for WLAN: Research Articles (2004)

In this paper, a simple self-adaptive contention window adjustment algorithm for 802.11 wireless local area networks (WLAN) is proposed and analyzed. Numerical results show that the new algorithm outperforms the standard 802.11 window adjustment algorithm. Compared with the standard and previously proposed enhancement algorithms, a salient feature of our algorithm is that it performs well in both heavy and light contention cases regardless of the packet sizes and physical versions. Moreover, the adaptive window adjustment algorithm is simpler than previously proposed schemes in that no live measurement of the WLAN traffic activity is needed. Copyright © 2004 John Wiley & Sons, Ltd.
MCM-41–Quaternary organic tetraalkylammonium hydroxide composites as strong and stable Brønsted base catalysts (1999)

Quaternary organic tetraalkylammonium hydroxide grafted on MCM-41 is a strong Brønsted base catalyst, and represents a useful alternative to soluble bases in reactions such as Knoevenagel condensations, Michael additions and aldol condensations because of their high catalytic activity under mild conditions, and good stability.
Células presentadoras de antígeno: células dendríticas y su papel en la lengua azul (2010)

Las células presentadoras de antígeno (CPA) desempeñan un papel fundamental&#13;\nen el desarrollo de la respuesta inmunitaria mediante el procesamiento y la&#13;\npresentación de antígenos, así como a través de distintos estímulos que favorecen la&#13;\nproliferación y diferenciación linfocitaria. Entre las CPA, las células dendríticas (CDs)&#13;\nson consideradas como las más eficientes en las funciones de presentación. En este&#13;\ntrabajo se abordan aspectos generales relacionados con la localización, estructura y&#13;\nfunción de estas células, así como con su importante papel en la instauración de la&#13;\nrepuesta inmunitaria. Junto a las células endoteliales y a los macrófagos, las CDs&#13;\nson consideradas células blanco del virus de la lengua azul (vLA), desempeñando&#13;\nun importante papel en la diseminación orgánica de éste. Además, las CDs parecen&#13;\njugar un importante papel como productoras o inductoras de sustancias vasoactivas&#13;\nresponsables de los cambios vasculares que caracterizan a la enfermedad, quedando&#13;\naún por determinar la influencia de estos mediadores químicos en la instauración de&#13;\nla respuesta inmunológica frente al virus, aspecto fundamental para el desarrollo y&#13;\nmejora de vacunas.
The Rate of Interleukin-1β Secretion in Different Myeloid Cells Varies with the Extent of Redox Response to Toll-like Receptor Triggering (2011)

Human myeloid cells activate the NLRP3 inflammasome and secrete interleukin (IL)-1β in response to various Toll-like receptor (TLR) ligands, but the rate of secretion is much higher in primary human monocytes than in cultured macrophages or THP-1 cells. The different myeloid cells also display different redox status under resting conditions and redox response to TLR activation. Resting monocytes display a balanced redox state, with low production of reactive oxygen species (ROS) and antioxidants. TLR engagement induces an effective redox response with increased ROS generation followed by a sustained antioxidant response, parallelled by efficient IL-1β secretion. Drugs blocking ROS production or the antioxidant response prevent the secretion of mature IL-1β but not the biosynthesis of pro-IL-1β, indicating that redox remodeling is responsible for IL-1β processing and release. Unlike monocytes, THP-1 cells and cultured macrophages have up-regulated antioxidant systems that buffer the oxidative hit provided by TLR triggering and suppress the consequent redox response. This aborted redox remodeling is paralleled by low efficiency IL-1β processing and secretion. High doses (5 mM) of H(2)O(2) overcome the high antioxidant capacity of THP-1 cells, restore an efficient redox response, and increase the rate of IL-1β secretion. Together these data indicate that a tightly controlled redox homeostasis in resting cells is a prerequisite for a robust redox response to TLR ligands, in turn necessary for the efficient inflammasome activation. Inflammasome activation by bacterial DNA is not modulated by redox responses, suggesting that redox-dependent regulation of IL-1β secretion is restricted to some inflammasomes including NLRP3 but excluding AIM-2.
The perm provenance management system in action (2009)

In this demonstration we present the Perm provenance management system (PMS). Perm is capable of computing, storing and querying provenance information for the relational data model. Provenance is computed by using query rewriting techniques to annotate tuples with provenance information. Thus, provenance data and provenance computations are represented as relational data and queries and, hence, can be queried, stored and optimized using standard relational database techniques. This demo shows the complete Perm system and lets attendants examine in detail the process of query rewriting and provenance retrieval in Perm, the most complete data provenance system available today. For example, Perm supports lazy and eager provenance computation, external provenance and various contribution semantics.
Chemical Modification of Halogenated Polymers Under Phase Transfer Conditions (1981)

Abstract The chemical modification of several polymers including poly (vinyl bromide), poly (chloromethyl styrene), poly (vinylidene bromide), and poly (epichlorohydrin) was studied using various nucleophiles in multiphase systems with the assistance of a phase transfer catalyst. Satisfactory results were obtained using o-dichlorobenzene as solvent and powerful nucleophiles. The use of dimethylformamide as solvent often resulted in large increases in both reaction rates and conversions but sometimes created other problems. With several polymers dehydrohalogenation or chain cleavage were observed and in general the more basic nucleophiles were more destructive. With poly (vinyl bromide) the reaction was used to produce efficiently polymers containing alkyl sulfide, methyl sulfone, vinyl sulfone, or thioethanol side chains with little apparent polymer degradation.