gebhart/patrepeval huggingface dataset:
Sign-bit based architecture for OFDM Acquisition for multiple-standards (2009)

This paper presents a hardware mapping of an auto-correlator for Orthogonal Frequency Division Multiplexing stage for three radio standards: LTE, DVB-H, and IEEE 802.11n. Hardware cost is minimized by using only the sign bit in the autocorrelation function. The frequency offset estimation procedure is dramatically simplified by reducing the phase of the envelope to ¿/2 resolution, which in turn reduces the need of specialized components. The architecture is synthesized towards a 65 nm low-leakage high threshold standard cell CMOS library. The 1-bit architecture reports an area reduction of 90% for memories, 56% for the logic and a power dissipation reduction of 35%, when compared to an identical 8-bit implementation. The approximate area occupied by the architecture is 0.03 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Power simulations for IEEE 802.11n packet reports a power dissipation of 42 ¿W.
Parametrization of High-Rank Line-of-Sight MIMO Channels with Reflected Paths (2022)

High-rank line-of-sight (LOS) MIMO systems have attracted considerable attention for millimeter wave and THz communications. The small wavelengths in these frequencies enable spatial multiplexing with massive data rates at long distances. Such systems are also being considered for multi-path non-LOS (NLOS) environments. In these scenarios, standard channels models based on plane waves cannot capture the curvature of each wave front necessary to model spatial multiplexing. This work presents a novel and simple multi-path wireless channel parametrization where each path is replaced by a LOS path with a reflected image source. The model fully captures the spherical nature of each wave front and uses only two additional parameters relative to the standard plane wave model. Moreover, the parameters can be easily captured in standard ray tracing. The accuracy of the approach is demonstrated on detailed ray tracing simulations at 28GHz and 140GHz in a dense urban area.
A Pulmonary Lactobacillus murinus Strain Induces Th17 and RORγt+ Regulatory T Cells and Reduces Lung Inflammation in Tuberculosis (2021)

The lungs harbor multiple resident microbial communities, otherwise known as the microbiota. There is an emerging interest in deciphering whether the pulmonary microbiota modulate local immunity, and whether this knowledge could shed light on mechanisms operating in the response to respiratory pathogens. In this study, we investigate the capacity of a pulmonary <i>Lactobacillus</i> strain to modulate the lung T cell compartment and assess its prophylactic potential upon infection with <i>Mycobacterium tuberculosis</i>, the etiological agent of tuberculosis. In naive mice, we report that a <i>Lactobacillus murinus</i> (<i>Lagilactobacillus murinus</i>) strain (CNCM I-5314) increases the presence of lung Th17 cells and of a regulatory T cell (Treg) subset known as RORγt<sup>+</sup> Tregs. In particular, intranasal but not intragastric administration of CNCM I-5314 increases the expansion of these lung leukocytes, suggesting a local rather than systemic effect. Resident Th17 and RORγt<sup>+</sup> Tregs display an immunosuppressive phenotype that is accentuated by CNCM I-5314. Despite the well-known ability of <i>M. tuberculosis</i> to modulate lung immunity, the immunomodulatory effect by CNCM I-5314 is dominant, as Th17 and RORγt<sup>+</sup> Tregs are still highly increased in the lung at 42-d postinfection. Importantly, CNCM I-5314 administration in <i>M. tuberculosis</i>-infected mice results in reduction of pulmonary inflammation, without increasing <i>M. tuberculosis</i> burden. Collectively, our findings provide evidence for an immunomodulatory capacity of CNCM I-5314 at steady state and in a model of chronic inflammation in which it can display a protective role, suggesting that <i>L. murinus</i> strains found in the lung may shape local T cells in mice and, perhaps, in humans.
Supplementary Figure 2 from A Preclinical Trial and Molecularly Annotated Patient Cohort Identify Predictive Biomarkers in Homologous Recombination–deficient Pancreatic Cancer (2023)

&lt;p&gt;Supplementary Figure 2 shows the results of a pilot monotherapy trial to evaluate regimen-related toxicity&lt;/p&gt;
Pulmonary middle lobe fixation using TachoComb in patients undergoing right upper lobectomy with complete oblique fissure (2004)

Postoperative lobar torsion is a life-threatening complication of pulmonary resection. To prevent this complication, pulmonary lobe fixation has been proposed. We present here a new technique of middle lobe fixation after right upper lobectomy, using TachoComb, a collagen fleece coated with fibrin glue. This technique may facilitate tight fixation of the middle lobe to the lower lobe of the right lung in patients undergoing right upper lobectomy with complete oblique fissure.
Elucidating Interfacial Stability between Lithium Metal Anode and Li Phosphorus Oxynitride via In Situ Electron Microscopy (2020)

Li phosphorus oxynitride (LiPON) is one of a very few solid electrolytes that have demonstrated high stability against Li metal and extended cyclability with high Coulombic efficiency for all solid-state batteries (ASSBs). However, theoretical calculations show that LiPON reacts with Li metal. Here, we utilize in situ electron microscopy to observe the dynamic evolutions at the LiPON–Li interface upon contacting and under biasing. We reveal that a thin interface layer (∼60 nm) develops at the LiPON–Li interface upon contact. This layer is composed of conductive binary compounds that show a unique spatial distribution that warrants an electrochemical stability of the interface, serving as an effective passivation layer. Our results explicate the excellent cyclability of LiPON and reconcile the existing debates regarding the stability of the LiPON–Li interface, demonstrating that, though glassy solid electrolytes may not have a perfect initial electrochemical window with Li metal, they may excel in future applications for ASSBs.
A modified cylindrical coordinate system for the geometric analysis of abdominal aortic aneurysms (2003)

Surgical repair of abdominal aortic aneurysms (AAA) is associated with a considerable mortality rate, thus making less invasive therapies appealing. One of the more popular therapies is the placement of an endovascular prosthesis. Its function is to maintain vessel patency while attenuating the load on the AAA wall. To avoid dislodgment and migration, it is very important that the prosthesis be appropriately sized. The designer must take into account the variety of shapes to which the prosthesis must conform, and the clinician must take care to select an appropriate length. We have developed a finite element based technique which can be used for the geometric analysis of AAA. The technique requires the description of the AAA in a cylindrical coordinate system whose z-axis passes cleanly through the inside of the AAA. For a highly tortuous AAA, such an axis may not exist, rendering the mapping until recently impossible. We present a modified cylindrical coordinate system for the 3D geometric analysis of highly tortuous AAA. The method offers the additional capability for determining AAA length, which is critical to the selection of endovascular prosthesis sizing.
Glenosphere design affects range of movement and risk of friction-type scapular impingement in reverse shoulder arthroplasty (2018)

Glenosphere configuration can be modified to increase range of movement in RSA. Friction-type scapular notching was most effectively reduced by use of a large-diameter glenosphere with 10° inferior tilt. Cite this article: Bone Joint J 2018;100-B:1182-6.
Self-Contained Nanocapsules Carrying Anticancer Peptides for Magnetically Activated and Enzyme-Cleaved Drug Delivery (2021)

A self-contained nanocapsule for nonspecific cytotoxic anticancer drug delivery and release activated by an enzyme and an alternating magnetic field (AMF) is introduced. This specific prodrug-like drug delivery platform is based on an esterase, an oligomer-based separating barrier, and an ester-linked anticancer peptide melittin encapsulated together in the enlarged pore spaces of the mesoporous silica nanoparticles. A superparamagnetic iron oxide nanoparticle core embedded in the center acts as a nanoheater to stimulate a cascade drug release. Each pore space was designed as a reaction nanovial for the activation of the drug release when the solution inside the nanovial is heated. By employing a thermoresponsive separating barrier as a shield of the peptide drug as well as a separator between the ester-containing peptides and the esterase, the nonspecific cytotoxic effect of the drug and off-target drug release are avoided because the drugs remain inactive in the absence of AMF stimulation. When AMF heating actuates the removal of the separating barrier and exposes the peptide drugs to the enzymes, drug release can be activated. In vivo antitumor experiments further revealed that the nanocapsules exhibited excellent biocompatibility and high tumor-targeting/inhibiting efficiency. The selected esterase, which is in close proximity to the ester-containing peptide drug, efficiently cleaves the ester bonds, thereby causing a catalytic release of peptide drugs and intensified anticancer efficacy.
Processing of Sheath-Core and Matrix-Fibril Fibers Composed of PP and a TLCP (1997)

Abstract Isotactic polypropylene (PP) was reinforced with Vectra B950 (VB), a thermotropic liquid crystalline polymer (TLCP), in two novel fiber spinning processes which both employ two extruders to allow separate thermal histories to be applied to PP and VB prior to their combination. In one process, a single VB melt stream was surrounded by a sheath of PP, in a manner comparable to a wire coating process, just prior to melt spinning to generate fibers possessing a sheath-core structure. The other process involved the distribution of continuous VB melt streams within a separately plasticated PP melt to form a composite melt which was drawn to create matrix-fibril fibers consisting of a PP matrix reinforced with VB fibrils. Both processes allow polymers with non-overlapping processing temperatures to be combined and melt spun to form composite fibers. The effect of fiber draw ratio on the tensile mechanical properties was assessed for composite fibers reinforced with 50 wt.-% (39 vol.-%) VB. Numerical simulations of the non-isothermal fiber drawing processes and an investigation of fiber morphology were undertaken in order to explain the mechanical properties. The composite fibers were compression molded at a temperature 80°C below the melting temperature of VB to form unidirectionally reinforced plaques. For both fiber types, the plaques exhibited excellent retention of fiber properties, illustrating the potential for using the fibers to form reinforced composite parts.
Regulation of immunoglobulin secretion by factor H of human complement. (1985)

As human B lymphocytes and macrophages carry surface receptors for Factor H (B1H), we investigated the possibility that this complement component regulates their function. Factor H inhibits immunoglobulin secretion by peripheral mononuclear cells (MNC) stimulated with pokeweed mitogen if present at the initiation of the cultures and at concentrations greater than 50 micrograms/ml. Factor H also inhibited stimulation and differentiation of purified B cells into immunoglobulin-secreting cells by Epstein-Barr virus (EBV). The inhibitory effect of Factor H was abrogated if anti-Factor H antibody was present in the cultures. EBV-transformed B-cell lines secreted less immunoglobulin if Factor H was present in the culture for at least 4 days. Culture of MNC with Factor H did not lead to the generation of suppressor T cells or macrophages. In contrast, Factor H did not cause proliferation of human peripheral total MNC or enriched T-cell or B-cell subpopulations. Also, Factor H did not inhibit the proliferation of MNC in response to several mitogens and antigens. Our results strongly indicate that Factor H is able to block human B-cell differentiation in vitro without blocking the proliferative ability of the cells. Factor H seems to act directly on the B cells through its receptor on their surface, since it inhibited T-dependent and T-independent B-cell differentiation but generated no suppressor cells.
Intimin-Specific Immune Responses Prevent Bacterial Colonization by the Attaching-Effacing PathogenCitrobacter rodentium (2001)

The formation of attaching and effacing (A/E) lesions on gut enterocytes is central to the pathogenesis of enterohemorrhagic (EHEC) Escherichia coli, enteropathogenic E. coli (EPEC), and the rodent pathogen Citrobacter rodentium. Genes encoding A/E lesion formation map to a chromosomal pathogenicity island termed the locus of enterocyte effacement (LEE). Here we show that the LEE-encoded proteins EspA, EspB, Tir, and intimin are the targets of long-lived humoral immune responses in C. rodentium-infected mice. Mice infected with C. rodentium developed robust acquired immunity and were resistant to reinfection with wild-type C. rodentium or a C. rodentium derivative, DBS255(pCVD438), which expressed intimin derived from EPEC strain E2348/69. The receptor-binding domain of intimin polypeptides is located within the carboxy-terminal 280 amino acids (Int280). Mucosal and systemic vaccination regimens using enterotoxin-based adjuvants were employed to elicit immune responses to recombinant Int280alpha from EPEC strain E2348/69. Mice vaccinated subcutaneously with Int280alpha, in the absence of adjuvant, were significantly more resistant to oral challenge with DBS255(pCVD438) but not with wild-type C. rodentium. This type-specific immunity could not be overcome by employing an exposed, highly conserved domain of intimin (Int388-667) as a vaccine. These results show that anti-intimin immune responses can modulate the outcome of a C. rodentium infection and support the use of intimin as a component of a type-specific EPEC or EHEC vaccine.
Reproducibility of the Magnitude of Lens Rotation Following Implantation of a Toric Intraocular Lens with Modified Haptics (2022)

The TECNIS Toric II IOL, with frosted, squared haptics, demonstrated low magnitude of postoperative IOL rotation, excellent uncorrected distance vision, and minimal residual astigmatism. The POC study design was supported, demonstrating that prototype non-toric monofocal IOLs can predict clinical performance of toric IOLs with the same haptic design.
Growth of Silicon Carbide (2010)

This chapter contains sections titled: Introduction Historical development Industrial production of SiC wafers Essentials of the bulk growth process and thermal-stress-generation mechanisms Growth-related defects Outlook Acknowledgements References
A Supramolecularly Assisted Transformation of Block‐Copolymer Micelles into Nanotubes (2009)

Once around the block: Incorporation of a rigid hydrogen-bonding benzamide unit, placed at the interface between two polymer blocks, in poly(ethylene glycol) (PEG)-(thio)urea-poly(L-lactide) (PLLA) block copolymers transforms the morphology of the block copolymers, from spherical micelles, as formed by PEG-PLLA diblock copolymers, into nanotubes in solution.
A 1.8V MOSFET-only sigma-delta modulator using compensated MOS-capacitors in depletion with substrate biasing (2000)

A low-voltage high-linearity MOSFET-Only ΣΔ modulator for speech band applications is presented. The modulator uses substrate biased MOSFETs in the depletion region as capacitors, linearized by a series compensation technique. A 2nd-order fully-differential single-loop architecture has been realized in a conventional 0.25µm digital n-well CMOS process without extra layers for capacitors. An SNDR of 72dB is obtained with 8kHz signal bandwidth. The circuit consumes about 1mW from a single 1.8V power supply and occupies an area of 0.08mm2.
Experimental determination of Auger capture coefficients in self-assembled quantum dots (2000)

Time-resolved studies of the wetting layer photoluminescence are combined with state-filling spectroscopy of the quantum dot and wetting layer emission to obtain carrier transfer rates from the wetting layer to the quantum dot states. With this method, capture rates can be measured for constant carrier concentrations in the wetting layer. The results show that the capture efficiency increases with the carrier concentration in the wetting layer, indicating the important role of Auger processes in the capture dynamics. In the analysis, the concept of capture cross section per unit time is introduced, and this is used to determine the single dot Auger capture coefficient in self-assembled dots. The value obtained can in principle be used as an input to model carrier capture in all self-assembled dot devices with similar dot layers.
Time-Frequency Analysis and Parameterisation of Knee Sounds for\n Non-invasive Detection of Osteoarthritis (2020)

Objective: In this work the potential of non-invasive detection of knee\nosteoarthritis is investigated using the sounds generated by the knee joint\nduring walking. Methods: The information contained in the time-frequency domain\nof these signals and its compressed representations is exploited and their\ndiscriminant properties are studied. Their efficacy for the task of normal vs\nabnormal signal classification is evaluated using a comprehensive experimental\nframework. Based on this, the impact of the feature extraction parameters on\nthe classification performance is investigated using Classification and\nRegression Trees (CART), Linear Discriminant Analysis (LDA) and Support Vector\nMachine (SVM) classifiers. Results: It is shown that classification is\nsuccessful with an area under the Receiver Operating Characteristic (ROC) curve\nof 0.92. Conclusion: The analysis indicates improvements in classification\nperformance when using non-uniform frequency scaling and identifies specific\nfrequency bands that contain discriminative features. Significance: Contrary to\nother studies that focus on sit-to-stand movements and knee flexion/extension,\nthis study used knee sounds obtained during walking. The analysis of such\nsignals leads to non-invasive detection of knee osteoarthritis with high\naccuracy and could potentially extend the range of available tools for the\nassessment of the disease as a more practical and cost effective method without\nrequiring clinical setups.\n
Conjugated Polyelectrolyte/Graphene Hetero‐Bilayer Nanocomposites Exhibit Temperature Switchable Type of Conductivity (2017)

The majority of charge carriers in conjugated polyelectrolyte (CPE)-PyrBIm4/graphene hetero-bilayers can be dynamically changed from electrons to holes, and vice versa, within a temperature range of 60 °C. Doping mechanisms under consideration include charge transfer from structural units in the CPE-PyrBIm4 backbone and/or field-effect doping from adjacent ionic functionalities. A new concept of the graphene/CPE/Au thermobarristor is proposed and practically realized. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
<title>Two-photon absorption-based 3D optical memories</title> (1996)

The rapid advance of image-dependent information processing and entertainment applications has accelerated the need for data storage solutions that offer high capacity and high data transfer rates while maintaining low system and media costs. Volume optical memories based on 2-photon absorption-induced photochromism enable random access writing and erasure to individual bits, lines, planes, or sets of planes within the volume of the memory media. The 3- dimensional nature of the storage enables high storage capacities (theoretically 10<SUP>12</SUP> bits/cm<SUP>2</SUP>) and parallel readout for high data transfer rates (1-100 Gb/s). The customizable nature of the media (dye-doped plastic) and efficient fluorescent mechanism of the memory readout promise cost-effective system and media solutions. Characterization experiments for erasable and read-only media have been performed, and system experiments for automated recording, and portable read-only memories have been designed and constructed.
Imaging systems and techniques (2009)

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The interplay between Epstein-Barr virus and the immune system: a rationale for adoptive cell therapy of EBV-related disorders (2010)

The Epstein-Barr virus has evolved a plethora of strategies to evade immune system recognition and to establish latent infection in memory B cells, where the virus resides lifelong without any consequence in the majority of individuals. However, some imbalances in the equilibrium between the inherent virus transforming properties and the host immune system can lead to the development of different tumors, such as lymphoproliferative disorders, Hodgkin's lymphoma, Burkitt's lymphoma, and nasopharyngeal carcinoma. The expression of viral antigens in malignant cells makes them suitable targets for immunotherapeutic approaches, which are mainly based on the ex vivo expansion of EBV-specific T cells. Indeed, the infusion of virus-specific cytotoxic T lymphocytes has proved not only to be safe and effective, but also capable of restoring or inducing a protective anti-virus immunity, which is lacking, albeit to a different extent, in every EBV-driven malignancy. The purpose of this review is to summarize the results of adoptive immunotherapy approaches for EBV-related malignancies, with particular emphasis on the immunological and virological aspects linked to the clinical responses obtained. Data collected confirm the clinical relevance of the use of EBV-specific cytotoxic T lymphocytes in the field of adoptive immunotherapy and suggest the increasing importance of this approach also against other tumors, concurrent with the increasing knowledge of the intimate and continuous interplay between the virus and the host immune system.