gebhart/patrepeval huggingface dataset:
DisplayCover (2015)

Tablet computers aim to bridge the gap between portability and productivity, reducing the need for users to carry multiple devices. However, despite increases in resolution, their displays are limited in size. This commonly results in sequential rather than parallel options for screen navigation, a significant drawback when multitasking. In this paper, we present DisplayCover, a tablet cover that integrates a physical keyboard as well as a touch and stylus sensitive thin-film e-ink display. We developed example applications to demonstrate the ability to dynamically alter the cover display content based on usage context, as well as concurrent access to multiple applications, stylus annotation, gestures and trackpad interactions.
Optimization of GaAsSb/InAlAs/InGaAs tunnel diodes for millimeter-wave detection (2015)

We evaluated optimal voltage sensitivity (S <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</sub> ) and noise equivalent power (NEP) of GaAsSb/InAlAs/InGaAs tunnel diode detectors in 220-330 GHz band at room temperature. The NEP values have strong dependence on the diode mesa size. With increasing the device area from 0.8×0.8μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> to 1.4×1.4μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , the estimated minimum NEP improved from 200pW/Hz <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1/2</sup> to 80pW/Hz <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1/2</sup> .
Digital RF Processor (DRP™) (2017)

Optimized wafer processes that meet the special demands of analog and radio frequency (RF) functions are normally employed and RF circuit designers are trained with such technologies in mind. This chapter presents key ideas and techniques used at Texas Instruments to develop two generations of Digital RF Processor (DRP) realized in aggressively scaled digital complementary metal oxide semiconductor (CMOS) technology. The DRP technology combines the radio frequency (RF), analog, digital, and software functionality. The main radio blocks, such as the local oscillator, transmitter and receiver, are built from the ground up to be compatible with digital scaled CMOS technology and be readily integrated with digital baseband and application processors. The power and sheer volume of consumer demand has driven cellular handsets to an incredible level of complexity featuring diverse modulation schemes and multiple protocols, as well as coverage of multiple frequency bands.
Neglect after right hemisphere stroke (1998)

Two patients with neglect after right hemisphere stroke performed more poorly than normal control subjects and left hemisphere-damaged control subjects as the area of spread in the gap increased. Right hemisphere-damaged patients did not differ from control subjects' performance on another visuospatial parameter--the degree of discontinuity between the line segments. These results support a defective attentional floodlight in neglect.
Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags (2019)

The cell nucleus is one of the most important organelles as a subcellular drug-delivery target, since modulation of gene replication and expression is effective for treating various diseases. Here, we demonstrate light-triggered nuclear translocation of guests using caged molecular glue (<sup>Caged</sup>Glue-R) tags, whose multiple guanidinium ion (Gu<sup>+</sup>) pendants are protected by an anionic photocleavable group (butyrate-substituted nitroveratryloxycarbonyl; <sup>BA</sup>NVOC). Guests tagged with <sup>Caged</sup>Glue-R are taken up into living cells via endocytosis and remain in endosomes. However, upon photoirradiation, <sup>Caged</sup>Glue-R is converted into uncaged molecular glue (<sup>Uncaged</sup>Glue-R) carrying multiple Gu<sup>+</sup> pendants, which facilitates the endosomal escape and subsequent nuclear translocation of the guests. This method is promising for site-selective nuclear-targeting drug delivery, since the tagged guests can migrate into the cytoplasm followed by the cell nucleus only when photoirradiated. <sup>Caged</sup>Glue-R tags can deliver macromolecular guests such as quantum dots (QDs) as well as small-molecule guests. <sup>Caged</sup>Glue-R tags can be uncaged with not only UV light but also two-photon near-infrared (NIR) light, which can deeply penetrate into tissue.
A wearable cardioverter defibrillator with a low false alarm rate (2022)

Abstract Introduction A wearable cardioverter defibrillator (WCD) is indicated in appropriate patients to reduce the risk for sudden cardiac death. Challenges for patients wearing a WCD have been frequent false shock alarms primarily due to electrocardiogram noise and wear discomfort. The objective of this study was to test a contemporary WCD designed for reduced false shock alarms and improved comfort. Methods One hundred and thirty patients with left ventricular ejection fraction ≤40% and an active implantable cardioverter defibrillator (ICD) were fitted with the ASSURE WCD (Kestra Medical Technologies) and followed for 30 days. WCD detection was enabled and shock alarm markers recorded, but shocks and shock alarms were disabled. All WCD episodes and ICD ventricular tachycardia/ventricular fibrillation (VT/VF) episodes were adjudicated. The primary endpoint was the false‐positive shock alarm rate with a performance goal of 1 every 3.4 days (0.29 per patient‐day). Results Of 163 WCD episodes, 4 were VT/VF and 159 non‐VT/VF (121 rhythms with noise, 32 uncertain with noise, 6 atrial flutter without noise). Only three false‐positive shock alarm markers were recorded; one false‐positive shock alarm every 1333 patient‐days (0.00075 per patient‐day, 95% confidence interval: 0.00015–0.00361; p &lt; .001). No ICD recorded VT/VF episodes meeting WCD detection criteria (≥170 bpm for ≥20 s) were missed by the WCD during 3501 patient‐days of use. Median wear was 31.0 days (interquartile range [IQR] 2.0) and median daily use 23.0 h (IQR 1.7). Adverse events were mostly mild: skin irritation (19.4%) and musculoskeletal discomfort (8.5%). Conclusion The ASSURE WCD demonstrated a low false‐positive shock alarm rate, low patient‐reported discomfort, and no serious adverse events.
Red Si–rhodamine drug conjugates enable imaging in GFP cells (2014)

Here we evaluated a series of Si-derivatized rhodamine (SiR) dyes for their ability to visualize a model drug in live cells. We show that a charge neutral SiR derivative (but not others) can indeed be used to follow the intracellular location of the model therapeutic drug in GFP cells.
Lattice instabilities near the critical V-V separation for localized versus itinerant electrons inLiV1−yMyO2(M=Cr or Ti)Li1−xVO2 (1991)

From the compositional dependences of the lattice parameters in the system ${\mathrm{LiV}}_{1\mathrm{\ensuremath{-}}\mathrm{y}}$Cr $_{\mathrm{y}}\mathrm{O}_{2}$, a critical V-V separation ${\mathrm{R}}_{\mathrm{c}}$=2.90\ifmmode\pm\else\textpm\fi{}0.01 \AA{} has been determined for an array of octahedral-site ${\mathrm{V}}^{3+}$ ions sharing common octahedral-site edges with six like nearest neighbors. A first-order transition on passing from the itinerant-electron regime R${\mathrm{R}}_{\mathrm{c}}$ to the localized-electron regime R&gt;${\mathrm{R}}_{\mathrm{c}}$ was also established. In ${\mathrm{LiVO}}_{2}$, the electron instability associated with an R\ensuremath{\approx}${\mathrm{R}}_{\mathrm{c}}$ is manifest by ${\mathrm{V}}_{3}$ trimer formation at temperatures T490 K with R${\mathrm{R}}_{\mathrm{c}}$ within a trimer and R&gt;${\mathrm{R}}_{\mathrm{c}}$ between trimers. Introduction of a mixed valence in ${\mathrm{Li}}_{1\mathrm{\ensuremath{-}}\mathrm{x}}$${\mathrm{VO}}_{2}$ results in a two-phase mixture in the interval 0\ensuremath{\lesssim}0.12; the metastable ${\mathrm{Li}}_{1\mathrm{\ensuremath{-}}\mathrm{x}}$${\mathrm{VO}}_{2}$ phase in the interval 0.12\ensuremath{\lesssim}x\ensuremath{\lesssim}0.33 disproportionates above a ${\mathrm{T}}_{\mathrm{t}}^{\ensuremath{'}}$\ensuremath{\approx}550 K into ${\mathrm{LiVO}}_{2}$ and Li[${\mathrm{V}}_{2}$]${\mathrm{O}}_{4}$. Comparisons are made between the instabilities associated with a W\ensuremath{\approx}U in the copper oxide superconductors and those in the layered and spinel vanadium oxides. In particular, attention is called to evidences for dynamic charge-density fluctuations that appear to be associated with superconductivity in the coper oxides, but not in the vanadium oxides.
Grain‐Boundary Defect Chemistry of Acceptor‐Doped Titanates: Inversion Layer and Low‐Field Conduction (1997)

The electronic and ionic conduction across grain‐boundary (GB) space‐charge depletion layers in acceptor‐doped SrTiO 3 ceramics have been investigated by admittance analysis in the time domain. The dependence on the acceptor concentration, the oxygen partial pressure during equilibration, and the temperature dependence of the GB conductivity are discussed and interpreted in terms of a defect‐chemistry model of the GB region using a numerical simulation technique.
Strong Carbon-Surface Dative Bond Formation by tert-Butyl Isocyanide on the Ge(100)-2 × 1 Surface (2014)

Carbon dative bond formation between an organic molecule and a semiconductor surface is reported here for the first time. Our studies show that the adsorption of tert-butyl isocyanide on the (100) surface of germanium, measured using Fourier transform infrared spectroscopy, temperature-programmed desorption, and density functional theory calculations, occurs via formation of a dative bond to the surface through the isocyanide carbon. The experimentally observed adsorption energy of 26.8 kcal/mol is the largest among any organic molecule dative bonded on the Ge(100)-2 × 1 surface studied to date. The dative-bonded adsorbate is characterized by a N≡C stretching frequency significantly blue-shifted from that of the free molecule. Moreover, the adsorbate N≡C vibrational frequency red-shifts back toward that of the free molecule upon increasing coverage. These spectroscopic effects are attributed to σ-donation of the isocyanide lone pair electrons to the surface.
Chiroselective Assembly of a Chiral Porphyrin−Fullerene Dyad: Photoconductive Nanofiber with a Top-Class Ambipolar Charge-Carrier Mobility (2010)

Upon slow admission of MeOH, the enantiomerically pure form of chiral amphiphilic porphyrin-fullerene dyad 1 in CH(2)Cl(2) self-assembles at 25 degrees C into nanofibers with a built-in donor/acceptor heterojunction, while its racemic form, under identical conditions, self-assembles into submicrometer-sized spheres with a donor/acceptor arrangement essentially different from that in the nanofiber assembly. Although a cast film of the latter hardly shows a photoconducting profile on micrometer-gap electrodes, the former sample clearly displays photoconduction with an ambipolar charge-transporting character. The electron and hole mobilities under zero electric field, as estimated from time-of-flight profiles, are 0.14 and 0.10 cm(2) V(-1) s(-1), respectively, which are comparable to or even better than those reported for top-class organic materials with a donor/acceptor heterojunction.
SMASH imaging. (1999)

SMASH imaging is a new MR imaging technique that can be used to multiply the speed of existing imaging sequences. It operates by using an array of radiofrequency (RF) detection coils to perform some of the spatial encoding normally accomplished with magnetic field gradients. The speed of the SMASH technique results from appropriate combinations of coil array RF signals in which multiple lines of image data are gathered simultaneously, rather than one after another. SMASH can be used in conjunction with most rapid imaging sequences, including EPI, resulting in multiplicative gains in imaging speed. This article reviews the basic principles of SMASH imaging, outlines requirements for practical implementation, and presents a variety of in vivo results, highlighting ways in which SMASH may be used to increase imaging speed and to improve image quality for clinical MR imaging applications.
Occupancy of Norepinephrine Transporter by Duloxetine in Human Brains Measured by Positron Emission Tomography with (S,S)-[18F]FMeNER-D2 (2017)

Norepinephrine transporter occupancy by clinical doses of duloxetine was approximately 30% to 40% in human brain as estimated using positron emission tomography with (S,S)-[18F]FMeNER-D2.
Structural, morphological, and kinetic studies of β-amyloid peptide aggregation on self-assembled monolayers (2011)

The misfolding and aggregation of β-amyloid peptides (Aβ) into amyloid fibrils, a process that has been pathologically linked to the onset of Alzheimer's disease, is dependent on the presence of a heterogeneous surface (e.g., cell membrane). Understanding of the kinetics of amyloid fibril formation and associated structural transition from monomers to intermediates and eventually to fibrils is critical for the development of viable therapeutic agents. In this work, using circular dichroism (CD), atomic force microscopy (AFM), surface plasmon resonance (SPR), and molecular dynamics (MD) simulations, we studied the adsorption, aggregation, and conformational changes of Aβ(1-42) from fresh monomers to fully grown fibrils on four model self-assembled monolayers (SAMs): hydrophobic CH(3)-terminated SAM, hydrophilic OH-terminated SAM, negatively charged COOH-terminated SAMs, and positively charged NH(2)-terminated SAM. The seeding effect of Aβ(1-42) on the kinetics of Aβ aggregation on different SAMs is also examined. The CD, AFM, and SPR data show that all of these SAMs greatly accelerate the formation of β-sheets and amyloid fibrils through surface-enhanced interactions, but Aβ(1-42) peptides preferentially adsorb on a hydrophobic CH(3)-SAM and a positively charged NH(2)-SAM with much stronger interactions than on a hydrophilic OH-SAM and a negatively charged COOH-SAM. MD simulations further reveal that hydrophobic interactions present a general driving force for Aβ adsorption on all SAMs. As Aβ aggregates grow into larger species by packing hydrophobic C-terminals to form a hydrophobic core while exposing hydrophilic and negatively charged N-terminals to solution, electrostatic interactions become more strengthened when they interact with the SAMs especially for the COOH-SAM and the NH(2)-SAM. Thus, both hydrophobic and electrostatic interactions contribute differently to different Aβ-SAM systems and to different aggregation stages. A postulated mechanism is proposed to describe the structure and kinetics of Aβ aggregation from aqueous solution to the SAMs, providing valuable insights into Aβ aggregation on biological cell membranes.
LAMC2 Regulates Key Transcriptional and Targetable Effectors to Support Pancreatic Cancer Growth (2023)

LAMC2 is a molecular target in PDAC that regulates a transcriptional network that unveils a dual drug combination for cancer treatment.
Operating Current Reduction in Nickel Oxide Correlated Electron Random Access Memories (CeRAMs) Through Controlled Fabrication Processes (2011)

Abstract Low temperature process for metal organic decomposition (MOD) derived stable and charge compensated thin NiO films is presented. The coordination number 'fine tuning' in nickel oxide Correlated Electron Random Access Memories (CeRAMs) is obtained via carbonyl ligand doping. Further regulation of the number of oxygen vacancies and the surface excess of metal ions is realized by selecting the most stable metal-oxide interfaces. Inserting the ultrathin homo- or heterogeneous oxide layers or oxygen diffusion barriers into the top metal-oxide interface is just one example. We have demonstrated the improved performance of the CeRAM cell obtained by a combination of material doping, layer grading, oxygen diffusion barrier and the small cell sizes. It is shown that optimization of various process conditions leads to the endurance parameters improvement and the write current reduction for relatively large device areas with external compliance circuitry. Further current reduction through the cell size scaling and the on-chip compliance circuitry will ensure CeRAM's programming speed sufficient for high-speed performance. These factors combined together unfold a novel opportunity for the fabrication of a memory cell with superior characteristics for universal high-density non-volatile memory. Keywords: Nonvolatile memoriesresistive switching memorytransition metal oxideCeRAM
The chemokine CCL17 is associated with protection against HIV-1 acquisition (2020)

Abstract Millions are exposed to the human immunodeficiency virus type 1 (HIV-1) every year, but not all exposed individuals become infected. This suggests a key role for host genetics in resilience or susceptibility to HIV-1 infection, but a comprehensive study of the genetic mechanisms contributing to HIV-1 acquisition risk is lacking. Here, we performed LD score regression analysis using summary statistics from the largest genome-wide association study of HIV-1 acquisition, consisting of 6,334 infected patients and 7,247 population controls. We found that HIV-1 acquisition is polygenic and highly heritable (28%). Genetic correlations performed alongside UK Biobank data revealed associations between HIV-1 acquisition and smoking, prospective memory and socioeconomic traits. Gene-level enrichment analysis identified EF-hand calcium binding domain 14 (EFCAB14) as a novel risk gene for HIV-1 acquisition. We also observed that risk variants for HIV-1 acquisition were significantly enriched for genes expressed in T-cells, but also those expressed in striatal and hippocampal neurons, which could explain the behavioral parameters genetically correlated with acquisition. Finally, we modeled how inter-individual variation in risk for HIV-1 acquisition influences the pre-exposed immune profile, by testing how individualized polygenic risk scores influence blood levels of 34 inflammatory markers in 406 HIV-1-negative individuals. We showed that higher genetic risk for HIV-1 acquisition was associated with lower levels of CCL17. Our findings corroborate a complex model for HIV-1 acquisition, whereby susceptibility is moderated by specific behavioral, cellular and immunological parameters.
Faculty Opinions recommendation of Visualizing specific protein glycoforms by transmembrane fluorescence resonance energy transfer. (2012)

Analyses of mice lacking glycosyltransferase have suggested that their pathological phenotypes are not attributable to the overall change of the sugar modification, but instead the result of changes of the glycan structures on a specific 'target' glycoprotein. Therefore, detecting or monitoring the glycosylation status of a specific protein in living cells is important, but no such methods are currently available. Here we demonstrate the detection of glycoforms of a specific glycoprotein using the fluorescence resonance energy transfer technique. Using model proteins, we detect characteristic fluorescence resonance energy transfer signals from the specific glycoform-bearing target glycoprotein. We also show that, upon insulin removal, sialylated glycoforms of green fluorescent protein-tagged GLUT4 seem to be internalized more slowly than non-sialylated GLUT4. This novel analytical imaging tool allows studying the roles of specific glycan modifications of a protein of interest. PMID: 22713749
Hydrolytic stability of one-step self-etching adhesives bonded to dentin. (2011)

The bond strength and ultramorphological data demonstrated that the bond of 1-SEAs to dentin degrades with time, although the degree of degradation is obviously material dependent.
In vitro analogs of photosystem II. Combined flash photolytic and conductometric study of light-induced oxygen evolution from water mediated by colloidal rubidium dioxide/titanium dioxide (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIn vitro analogs of photosystem II. Combined flash photolytic and conductometric study of light-induced oxygen evolution from water mediated by colloidal rubidium dioxide/titanium dioxideRobin Humphry-Baker, Jochen Lilie, and Michael GraetzelCite this: J. Am. Chem. Soc. 1982, 104, 2, 422–425Publication Date (Print):January 1, 1982Publication History Published online1 May 2002Published inissue 1 January 1982https://pubs.acs.org/doi/10.1021/ja00366a008https://doi.org/10.1021/ja00366a008research-articleACS PublicationsRequest reuse permissionsArticle Views195Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Lack of effect of oral choline supplement on the concentrations of choline metabolites in human brain (1998)

Recent reports suggest that oral choline supplement may alter the cerebral choline/creatine (Cho/Cr) ratio and might be used to treat neurodegenerative disorders of cholinergic transmission. Using both 1H and 31P MRS, we reexamined the Cho/Cr ratio and quantified cerebral choline and its major constituents: phosphoethanolamine (PE), phosphorylcholine (PC), glycerophosphorylethanolamine (GPE), and glycerophosphorylcholine (GPC). In the four brain locations examined, no significant increases in Cho/Cr, [Cho], or in its major constituents were found in response to an oral challenge of 50 mg/kg of choline bitartrate. Oral choline did not significantly affect human cerebral metabolism in the short term.
ChemInform Abstract: TIN‐119 M MOESSBAUER AND X‐RAY PHOTOELECTRON (ESCA) STUDIES OF TIN OXIDATION STATE AND BONDING IN BASE‐DIALKYLTIN PENTACARBONYLCHROMIUM AND TETRACARBONYLIRON COMPLEXES (I) (1974)

Abstract arks, T. J. (1973) l1, 2522‐25; De R. Mattner I [(CH3)3C‐]2SnM(CO)x ′ B a M: Fe,x=4 B: DMSO,THF b M: Cr, x= 5 Pyrjdjn ;Tomaja, D. L. und Zuckerman, p. of Chem., Northwest.
Direct Laser Interference Structuring as a Tool to Gradually Tune the Wetting Response of Titanium and Polyimide Surfaces (2009)

Direct laser interference structuring has been used for topographical surface design on titanium and polyimide. The wetting response of processed materials showed a roughness-dependant increase in contact angle starting at initially hydrophilic conditions.
Low-loss high power RF switching using multifinger AlGaN/GaN MOSHFETs (2002)

We demonstrate a novel RF switch based on a multifinger AlGaN/GaN MOSHFET. Record high saturation current and breakdown voltage, extremely low gate leakage current and low gate capacitance of the III-N MOSHFETs make them excellent active elements for RF switching. Using a single element test circuit with 1-mm wide multifinger MOSHFET we achieved 0.27 dB insertion loss and more than 40 dB isolation. These parameters can be further improved by impedance matching and by using submicron gate devices. The maximum switching power extrapolated from the results for 1A/mm 100 μm wide device exceeds 40 W for a 1-mm wide 2-A/mm MOSHFET.