gebhart/patrepeval huggingface dataset:
Quantum phase transition under pressure in the heavily hydrogen-doped iron-based superconductor LaFeAsO (2017)

Hydrogen (H)-doped LaFeAsO is a prototypical iron-based superconductor. However, its phase diagram extends beyond the standard framework, where a superconducting (SC) phase follows an antiferromagnetic (AF) phase upon carrier doping; instead, the SC phase is sandwiched between two AF phases appearing in lightly and heavily H-doped regimes. We performed nuclear magnetic resonance (NMR) measurements under pressure, focusing on the second AF phase in the heavily H-doped regime. The second AF phase is strongly suppressed when a pressure of 3.0 GPa is applied, and apparently shifts to a highly H-doped regime, thereby a ``bare'' quantum critical point (QCP) emerges. A quantum critical regime emerges in a paramagnetic state near the QCP, however, the influence of the AF critical fluctuations to the SC phase is limited in the narrow doping regime near the QCP. The optimal SC condition (${T}_{c}\ensuremath{\sim}48$ K) is unaffected by AF fluctuations.
Heralded single photons from a silicon nanophotonic chip (2012)

A highly nonlinear (γ≈3700/W·m) silicon coupled-resonator-optical-waveguide generated heralded single photons (g(2)(0) ≤ 0.19 ±0.03) and widely-spaced photon pairs with coincidences-to-accidentals ratio &gt;10 (cw) and &gt;23 (pulsed), and outperformed a 54x longer silicon nanophotonic waveguide.
SR-MPLS Data Plane with IPv6 Control Plane (2019)

This document reminds the existence of the Segment Routing (SR) MPLS
data-plane with IPv6 control-plane solution that is mature from a
standardization, productization and commercial deployment viewpoint.
Recent Discoveries from Nodal Aberration Theory (2010)

Nodal Aberration Theory (NAT) was discovered in 1977 and was last presented at this conference 25 years ago. This paper presents recent discoveries and why this theory is gaining in relevance for the future.
P‐30: Fine Patterning of Lateral Three Color Emitters for Organic EL Devices Using a Metal Mask Sliding in Vacuum Vapor Deposition (2000)

Abstract In order to form high‐resolusion pixels for a small organic elctroluminescent (EL) device having a three‐color independent emission system using a low molecular evaporation method, a metal mask sliding control system with a pulse control motor was made for the initial trials. This system has a substrate holding table which has the functions of rotation angle adjustment, adjustment of the XY direction movements, adjustment of the Z direction movements and an XY stage for a metal mask sliding which is based on the leaf spring structure. The patterning of the RGB thin films was done by precisely controlling the position of the XY stage for a metal mask sliding using a DC servomotor. An organic EL device, which has the sub‐pixel pitch of 33 μm × 100 μm, aperture ratio of 70% and 254 ppi (pixel/inch), has been manufactured using this system.
Protein evaluation of noog meal (Guizottia abyssinca) (1972)

This item was digitized from a paper original. If you need higher-resolution images for any content in this item, please contact us at repository@u.library.arizona.edu.
Challenges of managing food allergy in the developing world (2019)

Food allergy (FA) is currently a significant health care problem in the developing world. Widely varying study populations and methodologies, the use of surrogate markers such as self report or hospitalization rates due to anaphylaxis rather than objective methods, limits robust estimation of FA prevalence in low income settings. Also, allergy is under-recognized as a clinical specialty in the developing world which compromises the chance for accurate diagnosis. In this review, most published data on food allergens from developing or low income countries are displayed. The diagnostic challenges and limitations of treatment options are discussed. It seems that FA is an under-appreciated health care issue in the developing world, and accurate determination of its burden in low-income settings represents an important unmet need. Multicenter surveillance studies, using standardized methodologies, are, therefore, needed to reveal the true extent of the problem and provide epidemiological clues for prevention. Preventive strategies should be tailored to fit local circumstances in different geographic regions. In addition, studying the gene environment interactions and impact of early life microbiota on the expression of FA in developing communities would be worthwhile. Efforts and resources should be directed toward public health education and training of health care providers dealing with food allergic patients.
From Mice and Men to Earth and Space: Joint NASA–NCI Workshop on Lung Cancer Risk Resulting from Space and Terrestrial Radiation (2011)

On June 27-28, 2011, scientists from the National Cancer Institute (NCI), NASA, and academia met in Bethesda to discuss major lung cancer issues confronting each organization. For NASA, available data suggest that lung cancer is the largest potential cancer risk from space travel for both men and women and quantitative risk assessment information for mission planning is needed. In space, the radiation risk is from high energy and charge (HZE) nuclei (such as Fe) and high-energy protons from solar flares and not from gamma radiation. In contrast, the NCI is endeavoring to estimate the increased lung cancer risk from the potential widespread implementation of computed tomographic (CT) screening in individuals at high risk for developing lung cancer based on the National Lung Cancer Screening Trial (NLST). For the latter, exposure will be X-rays from CT scans from the screening (which uses "low-dose" CT scans) and also from follow-up scans used to evaluate abnormalities found during initial screening. Topics discussed included the risk of lung cancer arising after HZE particle, proton, and low-dose exposure to Earth's radiation. The workshop examined preclinical models, epidemiology, molecular markers, "omics" technology, radiobiology issues, and lung stem cells that relate to the development of lung cancer.
Changes in susceptibility of bovine sperm to in situ DNA denaturation during prolonged incubation at ambient temperature under conditions of exposure to reactive oxygen species and nuclease inhibitor (2001)

Sperm were incubated for up to 9 days in the presence or absence of exogenous hydrogen peroxide, phenylalanine, catalase and aurintricarboxylic acid to assess the influence of reactive oxygen species and inhibition of deoxyribonucleases on sperm chromatin stability. The assessment of sperm DNA susceptibility to in situ acid denaturation by the sperm chromatin structure assay did not detect any difference in chromatin stability between sperm incubated for 9 days under aerobic and anaerobic conditions in a diluent called 14G. Exposure to exogenous hydrogen peroxide under both aerobic and anaerobic conditions and to phenylalanine under aerobic conditions (which produces hydrogen peroxide by a reaction catalysed by the aromatic amino acid oxidase present in sperm) was detrimental to sperm chromatin stability, increasing its DNA susceptibility to in situ acid denaturation over the incubation time. This effect was eliminated if catalase was present in the diluent. Inclusion of the general deoxyribonuclease inhibitor aurintricarboxylic acid in the diluent severely decreased sperm chromatin stability under both aerobic and anaerobic conditions. Aurintricarboxylic acid was mildly cytotoxic, as revealed by viability assessment, under aerobic, but not under anaerobic, incubation conditions. Exogenous hydrogen peroxide, either directly added to the diluent or generated through the enzymatic oxidation of phenylalanine, was detrimental to sperm motility and the integrity of the plasma membrane.
Efficient GPU-accelerated elastic image registration (2008)

Elastic intra-patient registration can be used to correct for local motion within biomedical images. The application of elastic registration during interventional treatment is seri ously hampered by its considerable computation time. The Graphics Processing Units (GPU) can be used to accelerate the calculation of such elastic registrations, without chang ing the basic registration algorithm. This article discusses how elastic image registration, using cubic B-spline based deformation ¿elds, ef¿ciently can be approached to make use of the vast processing power of the GPU. Our approach employs an ef¿cient GPU-based cubic B-spline deforma tion ¿eld, and also calculates the similarity measure and its derivative on the GPU.
Towards Predicting the Cytochrome P450 Modulation: From QSAR to Proteochemometric Modeling (2017)

Drug metabolism determines the fate of a drug when it enters the human body and is a critical factor in defining their absorption, distribution, metabolism, excretion and toxicity (ADMET) characteristics. Among the various drug metabolizing enzymes, cytochrome P450s (CYP450) constitute an important protein family that aside from functioning in xenobiotic metabolism, is also responsible for a diverse array of other roles encompassing steroid and cholesterol biosynthesis, fatty acid metabolism, calcium homeostasis, neuroendocrine functions and growth regulation. Although CYP450 typically converts xenobiotics into safe metabolites, there are some situations whereby the metabolite is more toxic than its parent molecule. Computational modeling has been instrumental in CYP450 research by rationalizing the nature of the binding event (i.e. inhibit or induce CYP450s) or metabolic stability of query compounds of interest. A plethora of computational approaches encompassing ligand, structure and systems based approaches have been utilized to model CYP450-ligand interactions. This review provides a brief background on the CYP450 family (i.e. its roles, advantages and disadvantages as well as its modulators) and then discusses the various computational approaches that have been used to model CYP450-ligand interaction. Particular focus was given to the use of quantitative structure-activity relationship (QSAR) and more recent proteochemometric modeling studies. Finally, a perspective on the current state of the art and future trends of the field is also provided.
Dealbreaker: A Nonlinear Latent Variable Model for Educational Data (2016)

ISSN:2640-3498
Second harmonic generation in LiTaO3 thin films by modal dispersion and quasi phase matching (1996)

Green light was generated by second harmonic generation in LiTaO3 thin films grown on sapphire. We describe the optical properties of the thin films grown by rf magnetron sputtering. We report on the experimental conditions for second harmonic generation by modal dispersion and quasi phase matching. For quasi phase matching, proton exchange was used to periodically deaden the nonlinearity of the crystal.
Vascular dysfunction measured by fingertip thermal monitoring is associated with the extent of myocardial perfusion defect (2009)

Vascular dysfunction measured by DTM is associated with the extent of myocardial perfusion defect independent of age, gender, and cardiac risk factors.
[Correlation between carbamazepine serum level and clinical condition of acute poisoned patient]. (2009)

1. Positive correlation has been found at the serum CBZ concentrations and systolic blood pressure and pulse. 2. We failed to find any significant correlation between CBZ plasma level and the remaining parameters. 3. The heavier course of poisoning was not affirmed in the case of mixed intoxication in comparison to poisonings with only CBZ. 4. In persons treated with CBZ earlier, the course of poisoning was less severe.
Selective isolation of bone marrow stromal cells residing in the infarcted region of the brain after stroke (2006)

The therapeutic potential of exogenous bone marrow stromal cells (BMSC) has been demonstrated in different models of stroke and brain injury. BMSC selectively migrate and home to the site of cerebral injury. Although various techniques have shown that the BMSC reside in or around the site of the cerebral infarct, selective isolation of BMSC from infarct site has not been reported. Our objective was to isolate the BMSC that selectively migrate and home to the infarct site. Stroke was induced in C57BL/6 wild type (WT) mice by middle cerebral artery occlusion for 1 h, followed by 24 h reperfusion. BMSC were isolated either from H‐2Kb‐tsA58 (expresses SV40 large T antigen that allows cell division at 33°C) or from WT mice. BMSC were administered intravenously 24 h after the stroke. Mice were sacrificed 1 week after administration of BMSC. Infarcted hemispheres were removed and treated with 2% collagenase for cell isolation. Isolated cells were cultured at 33°C. Mice that received BMSC from H‐2Kb‐tsA58 showed improvement of neurological function comparable to mice that received BMSC from WT. BMSC from H‐2Kb‐tsA58 were able to grow at 33°C whereas neither the endogenous cerebral cells of the recipient mice nor the BMSC from WT donors were able to grow at this temperature. The use of subpopulations of BMSC derived from thermolabile large‐T transgenic mice that preferentially accumulate at sites of cerebral injury represents a novel and potentially useful strategy for characterizing the therapeutic properties of BMSC in cerebrovascular disease. Supported by R01 HL26441.
Featured Articles Microvascular network alterations in the retina of patients with Alzheimer's disease (2014)

Background: Although cerebral small-vessel disease has been implicated in the development of Alzheimer’s disease (AD), the cerebral microcirculation is difficult to visualize directly in vivo. Because the retina provides a noninvasive window to assess the microcirculation, we determined whether quantitatively measured retinal microvascular parameters are associated with AD. Methods: We conducted a case-control study (case:control matching z 1:2). Retinal photographs were analyzed using a computer program, and a spectrum of quantitative retinal microvascular parameters (caliber, fractal dimension, tortuosity, and bifurcation) were measured. Logistic regression models were used to compute the odds ratio (OR) and 95% confidence interval for AD adjusting for age, gender, ethnicity, smoking, hypertension, diabetes, hypercholesterolemia, and history of myocardial infarction. Results: We included 136 demented patients with AD and 290 age-gender-race-matched controls. Persons with narrower venular caliber (OR per standard deviation [SD] decrease, 2.01 [1.27–3.19]), decreased arteriolar and venular fractal dimension (OR per SD decrease 1.35 [1.08–1.68], 1.47 [1.17–1.84], respectively) and increased arteriolar and venular tortuosity (OR per SD increase, 1.84 [1.40–2.31], 1.94 [1.48–2.53], respectively) were more likely to have AD. These associations still persisted when only AD cases without a history of cerebrovascular disease were included. Conclusions: Patients with AD have altered microvascular network in the retina (narrower retinal venules and a sparser and more tortuous retinal vessels) compared with matched nondemented controls. These changes in retinal microvasculature may reflect similar pathophysiological processes in cerebral microvasculature in the brains of patients with AD. 2014 The Alzheimer’s Association. All rights reserved.
Peptide and Protein Dynamics and Low-Temperature/DNP Magic Angle Spinning NMR (2017)

In DNP MAS NMR experiments at ∼80–110 K, the structurally important −¹³CH₃ and −¹⁵NH₃⁺ signals in MAS spectra of biological samples disappear due to the interference of the molecular motions with the ¹H decoupling. Here we investigate the effect of these dynamic processes on the NMR line shapes and signal intensities in several typical systems: (1) microcrystalline APG, (2) membrane protein bR, (3) amyloid fibrils PI3-SH3, (4) monomeric alanine-CD₃, and (5) the protonated and deuterated dipeptide N-Ac-VL over 78–300 K. In APG, the three-site hopping of the Ala-Cβ peak disappears completely at 112 K, concomitant with the attenuation of CP signals from other ¹³C’s and ¹⁵N’s. Similarly, the ¹⁵N signal from Ala-NH₃⁺ disappears at ∼173 K, concurrent with the attenuation in CP experiments of other 15N’s as well as 13C’s. In bR and PI3-SH3, the methyl groups are attenuated at ∼95 K, while all other 13C’s remain unaffected. However, both systems exhibit substantial losses of intensity at ∼243 K. Finally, with spectra of Ala and N-Ac-VL, we show that it is possible to extract site specific dynamic data from the temperature dependence of the intensity losses. Furthermore, 2H labeling can assist with recovering the spectral intensity. Thus, our study provides insight into the dynamic behavior of biological systems over a wide range of temperatures, and serves as a guide to optimizing the sensitivity and resolution of structural data in low temperature DNP MAS NMR spectra.
An automated fault injection for evaluation of LUTs robustness in SRAM-based FPGAs (2015)

A new fault injection approach targeting the LUTs configuration bits of the Xilinx SRAM-based FPGAs is presented. It allows identifying all the configuration bits used by the LUTs of a specific design to inject Single Event Upsets (SEUs) and Multiple Bit Upsets (MBUs). The identification of the LUTs configuration bits is done by comparing the EBC files of a specific design before and after modifying its XDL file by inverting the LUTs logic functions. The fault injection is ensured by a fault injection macro provided by Xilinx. A Python script is deployed to automate the fault injection procedure. The proposed approach does not require extra tools to identify LUTs configuration bits and offers a 100% of fault coverage and is applicable to new Xilinx FPGA generations.
Selection of Internalizing Antibodies for Drug Delivery (2004)

Large non-immune (naïve) antibody gene diversity libraries displayed on filamentous phage have proven to be a reliable source of antibodies to any purified protein antigen (, , ). In some instances, it is possible to directly select peptides and antibody fragments that bind cell-surface receptors from filamentous phage libraries by incubation of phage libraries with a target cell line (, , , , ). This has led to a marked increase in the number of potential cell-targeting molecules. However, the isolation of cell type-specific antibodies from naïve libraries has been difficult because selections often result in crossreactive antibodies that bind to common cell-surface antigens ().
Supplementary Methods from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance (2023)

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Abstract B20: Design, synthesis and SAR studies of novel survivin inhibitors with potent antiproliferative properties (2015)

Abstract A series of novel survivin inhibitors were designed and synthesized based our recently reported compound UC-112. All the new analogs were tested against several cancer cell lines including multidrug-resistant melanoma cancer cell lines. The in vitro results showed that several compounds had excellent antiproliferative activity with IC50 values within nanomolar range. Mechanism of action of those new analogs was investigated by Western blot assay. The study confirmed that the new analogs acted by selectively suppressing survivin with the similar mechanism as the parent compound UC-112. Those new analogs represent promising agents that can be further developed for selective anticancer treatment. Citation Format: Min Xiao, Jin Wang, Yan Lu, Duane D. Miller, Wei Li. Design, synthesis and SAR studies of novel survivin inhibitors with potent antiproliferative properties. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Melanoma: From Biology to Therapy; Sep 20-23, 2014; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(14 Suppl):Abstract nr B20.
Phase 1 Study to Assess Safety, Tolerability and Pharmacokinetics of Single and Multiple Oral Doses of APX001 and to Investigate the Effect of Food on APX001 Bioavailability (2017)

APX001 is a first-in-class, intravenous (IV) and oral (PO) broad-spectrum antifungal agent in clinical development for the treatment of invasive fungal infections (IFIs) due to Candida, Aspergillus and rare molds. The active moiety APX001A inhibits Gwt1, an early step in glycosylphosphatidylinositol (GPI) anchor biosynthesis. Excellent in vivo efficacy has been demonstrated in murine models of IFIs with APX001A AUC0-24 target exposures ~ 80 µg.hours/mL. Eight subjects in Cohort 1a were randomized in a 6:2 ratio to receive APX001 or placebo. Single doses of IV 200 mg were infused over 3 hours followed by single (tablet) doses of 100, 300, and 500 mg, each separated by a 14-day washout period. Ten subjects in Cohort 1b were randomized in a 8:2 ratio to receive either APX001 or placebo. A single PO (tablet) dose of 400 mg was administered under fed and fasted conditions, each separated by a 14-day washout period. MAD Cohorts 2 and 3 were comprised of eight subjects randomized in a 6:2 ratio to receive APX001 or placebo. Subjects received PO (tablet) doses of 500 and 1000 mg daily for 14 days. Pharmacokinetic (PK) parameters for APX001A in plasma were calculated using non-compartmental analysis. Safety monitoring and intense PK sampling occurred throughout the trial. A safety committee reviewed the PK and safety data to determine dose escalation steps. Plasma exposure to APX001A was linear, dose proportional with low intersubject variability and a half-life of ~2.5 days. Accumulation of APX001A was observed in the MAD cohorts. After 14 days of dosing at 500 and 1000 mg AUC0-24 were 192 and 325 µg.hours/mL, respectively. The oral bioavailability was >90%. Administration of APX001 with a high fat, high calorie meal had no effect on the rate or extent of absorption. APX001 was well tolerated across all doses with no clinically significant adverse events observed. All subjects completed dosing. There were no dose limiting toxicities. Most of the adverse events (AEs) were mild, transient and required no treatment. The most common AE was headache. APX001 given orally is highly bioavailable, has no food effect and can exceed target exposures of APX001A for efficacy against Candida and Aspergillus at doses that are safe and well tolerated. M. R. Hodges, Amplyx Pharmaceuticals: Employee, Salary; E. Ople, Amplyx Pharmaceuticals Inc.: Employee, Salary; K. J. Shaw, Amplyx Pharmaceuticals Inc.: Employee, Salary; R. Mansbach, Amplyx Pharmaceuticals Inc.: Consultant, Consulting fee; S. P. Van Marle, PRA Health Sciences: Employee, Salary; E. J. Van Hoogdalem, PRA Health Sciences: Employee, Salary; W. Kramer, Amplyx Pharmaceuticals Inc.: Consultant, Consulting fee; P. Wedel, Amplyx Pharmaceuticals Inc.: Employee, Salary
Method for fast computation of infrared radiation from heated turbulent jets viewed through thick atmospheric layers (1998)

The simple effective method for computing the spectral thermal radiation intensity from jets of hydrocarbon fuel combustion products viewing through thick atmosphere layers is proposed. The method is based on (1) similarity of radiation characteristics of optically thin turbulent jets and (2) three-group approximation. The first approach can be used because jet radiation filtered by sufficiently thick atmospheric layer is concentrated mainly at frequencies where radiating volume is optically thin. Within three-group approximation developed for radiation transfer calculation in molecular rotational-vibrational bands the lines in each spectral interval are approximated by several (up to 3) groups of lines with the same lower energy levels. This allows one to account for the contribution of so called 'hot' lines that arise due to transitions between excited states and are weakly absorbed in low temperature atmosphere.
Message from the IEEE TrustCom/BigDataSE/ISPA 2016 General Chairs (2016)

Presents the introductory welcome message from the conference proceedings. May include the conference officers' congratulations to all involved with the conference event and publication of the proceedings record.