gebhart/patrepeval huggingface dataset:
A 4-channels rad-hard delay generator ASIC with 1-ns minimum time step for LHC experiments (1998)

reset logic and the chip internal registers.DMILL standard cells were developed for CERN by IMEC, Belgium. CHIP ARCHITECTUREThe ASIC can delay 4 digital signals in the range 0-24 ns with 1 ns single step.The delay values of the four channels can be independently programmed by an I2C field bus interface.A delay locked loop (DLL) generates the control voltage used for controlling the four delay channels.The common control voltage guarantees independence from process, supply voltage and temperature variations.The DLL is synchronised to an external 40 MHz clock signal.A first version of the chip was developed in 0.8 pm CMOS technology.The design of the prototype has then been transferred with few modifications to DMILL radiation hard process.Design functionality and measurement results will be presented.Figure 1 shows the basic structure of the chip.A central delay locked loop (DLL) is used for chip timing control.The DLL receives as input the external 40 MHz reference clock.It locks on this signal, and assures the right timing to the four delay lines.
Reorganization and crystallite formation in Langmuir-Blodgett films (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReorganization and crystallite formation in Langmuir-Blodgett filmsD. K. Schwartz, R. Viswanathan, and J. A. N. ZasadzinskiCite this: J. Phys. Chem. 1992, 96, 25, 10444–10447Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://pubs.acs.org/doi/10.1021/j100204a059https://doi.org/10.1021/j100204a059research-articleACS PublicationsRequest reuse permissionsArticle Views137Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Maintaining Three-Dimensional Integrity Of Atuned Source Array (1977)

Abstract Most published signatures of arrays of seismic sources have been obtained under static or near-static conditions. Under actual operating conditions the effective source characteristics may change, and the changes may be considerable along a seismic line. This paper describes experimental measurements of the far-field signature of an air-gun array made under operational conditions. Variations in marine source signature degrade the quality of seismic data. A major function of a source control system is to minimize shot-to-shot variations. Some source variations will remain despite source control. These can be removed in subsequent processing. Near-field waveforms are observed near each source on every shot. A composite waveform is manufactured from these and recorded for each shot. Signature correction, a deterministic deconvolution process which utilizes this composite waveform, is applied to the data in subsequent processing to remove the effects of remaining source variations. An example shows the improvement in data quality which can be achieved by such processing. Introduction Airguns are the predominant energy source used in marine seismic exploration. In 1975, 59% of all marine seismic data (as measured in line miles) was obtained using airgun sources (Espey 1976). Airguns store a volume of compressed air under very high pressure and on command release this air suddenly into the water. The potential energy stored in the compressed air is the product of the volume and the differential pressure of the air with respect to hydrostatic pressure. Not all of the air is released into the water on an individual firing, however. The firing of an airgun produces a peak pressure build-up. It is generally considered desirable to have the peak pressure be as large as possible. With small guns sufficiently far apart that they do not interact.increase in gun volume produces an increase in peak pressure proportionate to the cube root. However, with larger guns the peak pressure increases less rapidly because the release of the air into the water is limited by the size of the ports through which the air must flow. If several non-interacting guns are fired so that their pressures peak at the same time. the pressures effectively add as the combined wavefront is concerned. The waveshape which results from firing an individual airgun (Fig. 1) shows oscillations of the bubble of air after the main burst of energy. The repetition rate of the bubble oscillation depends on the amount of air released into the water. This bubble oscillation sometimes continues over a number of cycles until damping reduces it to a low level. Bubble oscillation effects can be reduced by use of "waveshape kits" which divide the gun's air storage chamber into two portions connected by a small orifice. Some of the air is retarded because of the time required to flow through this orifice after gun firing and this tends to delay and make less sharp the subsequent bubble collapse and thus decrease the amplitude of subsequent oscillations.
Thermal optimization of a solar cell carrier for concentrator systems (2011)

Solar cell efficiency decreases as its temperature increases. Therefore, it is necessary to design a thermally optimal solar cell carrier that will maintain a minimal solar cell temperature. To achieve this optimal solar cell carrier design, a finite-element analysis model of the solar cell on carrier was developed. This numerical model was experimentally calibrated against a known design, in which the average solar cell temperature was determined by examining the shift in the open circuit voltage. This allowed us to explore the relationship between the carrier geometry and the average solar cell temperature. That is, the solar cell carrier is characterized by two independent thermal resistances: the uniform flow thermal resistance, and the thermal spreading resistance. As the copper thickness was increased, the uniform flow resistance acted to raise the cell temperature while the spreading thermal resistance decreased the cell temperature. Therefore, when the carrier geometry minimized the thermal resistances, it was found that the minimum solar cell temperature was achieved at a copper thickness between 1.5 and 3 mm depending on the surface area of the carrier. This optimized carrier design reduced the average solar cell temperature by 16 &deg;C, which corresponds to an increase of 0.8% in cell efficiency at 1666 suns as compared to the original design used to experimentally calibrate the numerical model.
A fluorescent biosensor-based platform for the discovery of immunogenic cancer cell death inducers (2019)

Systemic anticancer immunity can be reinstated via the induction of immunogenic cell death (ICD) in malignant cells. Thus, certain classes of cytotoxic compounds, for example, anthracyclines, oxaliplatin and taxanes are endowed with the capacity to act on cancer cells to ignite <i>premortem</i> stress pathways that lead to the surface exposure of calreticulin (CALR) and the cellular release of adenosine triphosphate, annexin A1, high mobility group B1 and type-1 interferons. Altogether, these alterations constitute the hallmarks of ICD. Here we report the design of a discovery pipeline for the identification of novel ICD inducers by means of a phenotypic screening platform. The use of fluorescent biosensors as proxies for the manifestation of ICD hallmarks has enabled the exploration of large collections of chemical compounds by automatized screening routines. Imaging-based assessment and phenotypic selection led to the identification of potential ICD inducers that could be validated further <i>in</i><i>vitro</i> and <i>in</i><i>vivo</i>, confirming that <i>bona fide</i> ICD inducers possess the capacity to induce immunological long-term memory and to confer resistance against rechallenge with syngeneic tumors. Machine learning algorithms analyzing the physicochemical properties of ICD inducers can assist in the preselection of compounds with potential ICD-stimulatory properties, further accelerating the screening efforts designed to develop new immunotherapeutic agents.
Effects of group velocity dispersion on self/cross phase modulation in a nonlinear Sagnac interferometer switch (1992)

Time-resolved numerical analysis of a nonlinear Sagnac interferometer switch (NSIS) reveals that the combined effects of group velocity dispersion (GVD), self phase modulation, cross phase modulation, and pump-probe walk-off seriously degrade switching performance when the soliton number N of the pump pulse is under 5. This means that the peak power of short pump pulses cannot be reduced to less than the critical value at N>5 to prevent the effect of GVD. This restriction is more severe for pump pulses in the anomalous dispersion region than for those in the normal dispersion region because of higher-order soliton compression. System designs for time-division demultiplexers that use NSISs and picosecond pump pulses generated by a laser-diode coupled to erbium-doped fiber amplifiers are discussed. It is found that 1:32 demultiplexing from 160 to 5 Gb/s and 1:8 demultiplexing from 80 to 10 Gb/s with a switching contrast of more than 60 are possible using diode-laser-pumped 1- and 2-ps pump pulses, respectively.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Deep Graphics Encoder for Real-Time Video Makeup Synthesis from Example (2021)

While makeup virtual-try-on is now widespread, parametrizing a computer graphics rendering engine for synthesizing images of a given cosmetics product remains a challenging task. In this paper, we introduce an inverse computer graphics method for automatic makeup synthesis from a reference image, by learning a model that maps an example portrait image with makeup to the space of rendering parameters. This method can be used by artists to automatically create realistic virtual cosmetics image samples, or by consumers, to virtually try-on a makeup extracted from their favorite reference image.
GDNF triggers a novel Ret‐independent Src kinase family‐coupled signaling via a GPI‐linked GDNF receptor α1 (1999)

Glial cell line-derived neurotrophic factor (GDNF) has potentially great clinical importance in the treatment of Parkinson's disease and several other neurodegenerative diseases, however its intracellular signaling mechanisms are poorly understood. Here we show that upon GDNF binding glycosyl-phosphatidylinositol (GPI)-linked GDNF receptor alpha1 (GFRalpha1) activates cytoplasmic Src family tyrosine kinase(s) in Ret tyrosine kinase-deficient cultured mouse dorsal root ganglion neurons and in two Ret-negative cell lines. GFRalpha1-mediated Src-type kinase activation subsequently triggers phosphorylation of mitogen-activated protein kinase, cAMP response element binding protein and phospholipase Cgamma. We therefore conclude that GDNF can activate intracellular signaling pathways Ret-independently via GPI-linked GFRalpha1.
Compact modeling and analysis of the Partially-Narrow-Mesa IGBT featuring low on-resistance and low switching loss (2015)

A compact model for the Partially-Narrow-Mesa (PNM) IGBT is developed. The model reproduces the measured specific feature of a substantial collector current enhancement. Simulated switching characteristics are also verified to reproduce the measurement data. It is further demonstrated that a small switching-loss increase in the studied IGBT structure is overcompensated by the conduction-loss reduction, resulting in reduction of the total loss in comparison to the conventional IGBT structure.
Pulsed electrical technologies assisted extraction of polyphenols from grape seeds: comparison of arc streamer and pulsed electric field (2013)

International audience
Inhibition of Histone Methylation Arrests Ongoing Graft-Versus-Host Diseases in Mice by Selectively Inducing Apoptosis of Alloreactive Effector T Cells (2011)

Abstract Abstract 820 Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment option for patients with hematological malignancies. However, its success is limited by life-threatening graft-versus-host disease (GVHD). Novel approaches are needed to control GVHD. Recent studies have shown the importance of histone methylation in regulating the expression of genes associated with effector T cell differentiation and proliferation. Using several mouse models of allo-HSCT, we report that in vivo administration of the histone methylation inhibitor 3-Deazaneplanocin A (DZNep) arrested ongoing GVHD while preserving graft-versus-leukemia activity (GVL). To assess the therapeutic effect of pharmacologic modulation of histone methylation on GVHD, we administered DZNep to BALB/c mice receiving major histocompatibility-mismatched C57BL/6 mouse T cells 7 days after transplantation, in which GVHD had been fully established. Notably, injection of 12 doses of DZNep controlled the disease in these recipients, with approximately 80% of them surviving long-term without significant clinical signs of GVHD. We found that in vivo administration of DZNep caused selective apoptosis in alloantigen-activated T cells, but did not impair the generation of effector T cells that produced inflammatory cytokines (e.g., TNF-α, IFN-γ and IL-17) and cytotoxic molecules (e.g., granzyme B and Fas ligand). As a result, alloreactive T cells retained potent GVL activity, leading to improved overall survival of the recipients challenged by leukemic cells. These data suggest that DZNep-mediated inhibition of GVHD may be accounted for by reduced number of alloreactive effector T cells. In vitro culture assays showed that DZNep treatment induced apoptosis in T cells activated by anti-CD3/CD28 antibodies but not in naive T cells stimulated by IL-2 or IL-7. This effect was associated with DZNep's ability to selectively reduce trimethylation of histone H3 lysine 27 (H3K27), deplete the histone methyltranferase Ezh2 that specifically catalyzes trimethylation of H3K27, and activate Ezh2-repressed pro-apoptotic gene Bim. Inactivation of Bim partially protected alloreactive T cells from DZNep-mediated apoptosis. Importantly, unlike DNA methylation inhibitors, inhibition of histone methylation by DZNep had no toxicities to hematopoietic cells or impairment on the reconstitution of hematopoiesis and thymopoiesis. Our findings indicate that modulation of histone methylation may have significant implications in the development of novel approaches to treat established GVHD and other T cell-mediated inflammatory disorders in a broad context. Disclosures: No relevant conflicts of interest to declare.
Biomechanical Effect of Superior Capsule Reconstruction Using a 3‐mm and 6‐mm Thick Acellular Dermal Allograft in a Dynamic Shoulder Model (2019)

Graft thickness may affect the clinical success following SCR with commercially available dermal allografts. Using a thicker (>3 mm) graft was able to biomechanically better restore native glenohumeral joint properties.
Hepatitis C recurrence and fibrosis progression are not increased after living donor liver transplantation: A single-center study of 289 patients (2007)

Today, hepatitis C virus (HCV) is the leading cause for liver transplantation (LT) and viral recurrence is almost universal. It has been suggested that viral replication within the transplanted tissue might be increased in organs of reduced size such as LD grafts. In the current literature the data is controversial, with many studies lacking routine liver biopsies. We performed a retrospective analysis of 289 HCV-LT (20 LD splits) patients receiving transplants between 1997 and 2005. Patient and organ survival, intensity of HCV recurrence, and fibrosis progression were analyzed with respect to deceased donor (DD) LT (DDLT) or living donor (LD) LT (LDLT). Organ and patient survival was significantly better for full-size recipients than for split-liver patients, with P = 0.037 for organ survival and P = 0.037 for patient survival; yet there were no significant differences when split-liver patients with large hepatocellular carcinoma (HCC) beyond the Milan criteria (n = 3) were excluded from the analysis (P > 0.05). First year fibrosis progression was 1.29 in full-size grafts and 1.07 in split-livers (P = not significant). In conclusion, in our patient sample, intensity of HCV recurrence was not increased in LD graft recipients compared to full-size recipients. Patient and organ survival were similar when patients with large HCC and early tumor recurrence were excluded from analysis. LDLT can therefore be advocated for HCV patients.
Optimization of return electrodes in neurostimulating arrays (2016)

Accurate modeling of multielectrode arrays helps optimize the electrode configuration to maximize the spatial resolution, contrast and dynamic range of retinal prostheses.
Inhibition of BMI1, a Therapeutic Approach in Endometrial Cancer (2018)

With rising incidence rates, endometrial cancer is one of the most common gynecologic malignancies in the United States. Although surgery provides significant survival benefit to early-stage patients, those with advanced or recurrent metastatic disease have a dismal prognosis. Limited treatment options include chemotherapy and radiotherapy. Hence, there is a compelling need for developing molecularly targeted therapy. Here, we show that the polycomb ring finger protein BMI1, also known as a stem cell factor, is significantly overexpressed in endometrial cancer cell lines, endometrial cancer patient tissues as well as in nonendometrioid histologies and associated with poor overall survival. PTC-028, a second-generation inhibitor of BMI1 function, decreases invasion of endometrial cancer cells and potentiates caspase-dependent apoptosis, while normal cells with minimal expression of BMI1 remain unaffected. In an aggressive uterine carcinosarcoma xenograft model, single-agent PTC-028 significantly delayed tumor growth and increased tumor doubling time compared with the standard carboplatin/paclitaxel therapy. Therefore, anti-BMI1 strategies may represent a promising targeted approach in patients with advanced or recurrent endometrial cancer, a population where treatment options are limited. <i>Mol Cancer Ther; 17(10); 2136-43. ©2018 AACR</i>.
ChemInform Abstract: Endothelin Antagonists. Part 3. Discovery of EMD 122946, a Highly Potent and Orally Active ETA Selective Antagonist. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Total Synthesis of the Lycopodium Alkaloids Magellanine and Magellaninone by Three-fold Annulation of 2-Cyclopentenone (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal Synthesis of the Lycopodium Alkaloids Magellanine and Magellaninone by Three-fold Annulation of 2-CyclopentenoneJohn P. Williams, Dirk Friedrich, Emmanuel Pinard, Brian A. Roden, Leo A. Paquette, and D. R. St. LaurentCite this: J. Am. Chem. Soc. 1994, 116, 11, 4689–4696Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://pubs.acs.org/doi/10.1021/ja00090a017https://doi.org/10.1021/ja00090a017research-articleACS PublicationsRequest reuse permissionsArticle Views1085Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The IP/MPLS over ASON/GMPLS test bed of the IST project LION (2003)

The introduction of intelligence for management and control of optical networks and the interworking of different resilience capabilities in the IP/multiprotocol label switching (MPLS) and optical layers are two important issues for the evolution of the telecom networks in the next years. This paper analyzes these topics and reports the main results obtained in the European IST project LION. In particular, it describes an experimental feasibility demonstration of setup/teardown of soft-permanent optical connections with generalized MPLS signaling in a managed, multivendor, and multidomain test bed. Moreover, it describes the results of resilience experiments in single-layer (MPLS traffic engineering fast reroute or optical restoration) and multilayer configurations where the two mechanisms are coordinated by configuring a holdoff timer in the IP/MPLS layer.
Combination of Searches for Invisible Higgs Boson Decays with the ATLAS Experiment (2019)

Dark matter particles, if sufficiently light, may be produced in decays of the Higgs boson. This Letter presents a statistical combination of searches for H→invisible decays where H is produced according to the standard model via vector boson fusion, Z(ℓℓ)H, and W/Z(had)H, all performed with the ATLAS detector using 36.1 fb^{-1} of pp collisions at a center-of-mass energy of sqrt[s]=13 TeV at the LHC. In combination with the results at sqrt[s]=7 and 8 TeV, an exclusion limit on the H→invisible branching ratio of 0.26(0.17_{-0.05}^{+0.07}) at 95% confidence level is observed (expected).