gebhart/patrepeval huggingface dataset:
Effects of 17 alpha-ethinyl estradiol on the serum lipoproteins of cholesterol-fed diabetic rats. (1980)

Large doses of 17 alpha-ethinyl estradiol were administered to rats made diabetic by administration of streptozotocin and fed a diet containing 2% cholesterol and 1% cholic acid. Before estrogen treatment, these rats were severely hypercholesterolemic and had high concentrations of lipoproteins of d < 1.006 g/ml (very low density lipoproteins, VLDL), d = 1.006 to 1.03 g/ml (intermediate density lipoproteins, IDL), and d = 1.03 to 1.063 g/ml (low density lipoproteins, LDL), and low concentrations of lipoproteins of d = 1.063 to 1.21 g/ml (high density lipoproteins, HDL). The VLDL contained two populations of particles with a mean diameter of 1150 and 350 A, respectively. The IDL contains only the latter particles. These particles are unusual in that they contain apolipoprotein A-I in addition to their usual complement of apolipoproteins. After estrogen treatment, the concentrations of both large and smaller particles in VLDL were greatly decreased as were the concentrations of IDL and LDL; apo A-I was no longer present in the residual VLDL and IDL. HDL phospholipid, protein, and cholesterol increased 7-fold, 4-fold, and 2-fold, respectively. Studies by others have shown that large doses of estrogen enhance uptake of LDL by the liver and this is associated with an increase in the saturable binding sites for LDL on liver membranes. The present studies suggest that these binding sites recognize lipoproteins other than LDL. Furthermore, the enhanced uptake of these lipoproteins appears to result in transfer of their surface components to HDL.
Validating New Reagents: Roadmaps Through the Wilderness (2006)

One of the most frequent quality control issues faced by laboratory professionals is how to respond appropriately to a shift in quality control (QC) following a reagent lot change. Possible actions include adjusting the control range, checking for shifts in patient data, or simply ignoring the QC shift. We offer a systematic approach to shifted quality control and/or patient data following a reagent lot change. We divide laboratory tests into 3 types, (1) tests for which the analysis of QC specimens is sufficient, (2) tests which demonstrate between reagent lot shifts infrequently, and (3) tests with between lot variation. Depending on the test type, specific information is gathered about the magnitude of the shifts in either the QC and/or the patient data. The control mean is reset following an isolated quality control shift. Evaluation of the shift in patient data is initiated by the laboratory director when the shift exceeds a multiple of the allowable error.
Acridine derivatives activate p53 and induce tumor cell death through bax (2005)

CP-31398 activates wild-type p53 by a novel mechanism that does not involve phosphorylation of the amino-terminus of p53 and disassociation of MDM2. To identify more potent CP-31398-like p53 activators, we synthesized 4 acridine derivatives with a similar structure to CP-31398. These four compounds induced strong p53 transcription in cells with wild-type p53. We also found that several randomly chosen acridine derivatives, including 9-aminoacridine, amsacrine, quinacrine and acridine orange, induced p53 transcriptional activity. All these acridine derivatives stabilized p53 protein by blocking its ubiquitination, without phosphorylation of ser15 or ser20 on p53. Furthermore, acridine derivatives induced p53-dependent cell death. Knockout of Bax, a p53 target and a key cell death inducer in both intrinsic and extrinsic apoptotic pathways, blocked acridine derivatives from inducing cell death. In addition, in vivo delivery of quinacrine and amsacrine induced p53 transcriptional activity in tumor xenografts. Our results reveal that DNA-intercalating acridine derivatives can induce p53 stabilization by a manner similar to CP-31398. These findings provide insights into p53 regulation in response to DNA intercalating drugs and may assist new anti-cancer drug design.
Fabrication of a Highly Porous Bioactive Glass–Ceramic Scaffold with a High Surface Area and Strength (2005)

A bioactive glass–ceramic scaffold was fabricated, in which two interlaced three‐dimensional (3‐D) glass–ceramic walls could serve as active surfaces for the formation of a bond to bone. For its fabrication, a 3‐D graphite network acting as a template was prepared using the rapid prototyping method, and then uniformly dip coated with a melt‐derived glass slurry. The resultant sample was heat treated at 900° or 1000°C for 5 h to remove the graphite network and densify the glass–ceramic walls. The fabricated sample exhibited an ultra‐high porosity (∼95%), high compressive strength (0.2±0.03 MPa), as well as a tightly controlled pore structure. In addition, this sample had a high surface area owing to its unique structure, which was expected to enhance the rate of bone growth.
Electron transport properties in Nb and NbN cluster-assembled films produced by a plasma–gas–condensation cluster source (2003)

Nb and NbN cluster-assembled films were produced by a plasma–gas–condensation cluster deposition apparatus and examined by transmission electron microscopy, electrical resistivity, and ultraviolet photoemission spectroscopy. The electron diffraction patterns of the Nb and NbN clusters displayed body-centered-cubic and NaCl-type diffraction rings, respectively. The electrical sheet resistance, R□, of both Nb and NbN cluster-assembled films, however, showed no superconductivity down to 2 K. We found a linear relation in the log R□ versus T−1/4 plot for the Nb cluster assembly, suggesting an electron localization effect. For the NbN cluster-assembly, on the other hand, R□ showed a semiconductor type temperature dependence, which is consistent with the valence electron spectra.
REAL-TIME DISSONANCIZERS: TWO DISSONANCE-AUGMENTING AUDIO EFFECTS (2008)

We present two simple perceptually motivated audio effects designed to increase the perceived sensory dissonance/roughness (a process we call “dissonancization”) of audio input. The first involves heterodyning multiple bands of the audio signal at different frequencies to break each sinusoid in each band into two sinusoids separated in frequency by the amount that Kameoka and Kuriyagawa [1] predict will produce a maximally dissonant effect. The second attempts to increase the depth of modulation caused by existing beating partials by exponentiating the amplitude envelope within small bands, enhancing the perceived roughness already present in the signal. The first algorithm can produce very dramatic effects even for very consonant inputs, whereas the second tends to produce a more subtle effect. Both algorithms are quite simple to understand and implement and computationally inexpensive enough to be used in real time, but produce perceptually interesting results. The effects can be selectively applied so as to affect only desired frequency ranges, and can be continuously controlled (e.g. in a performance context) to have more or less impact.
Noncanonical Wnt-4 Signaling Enhances Bone Regeneration of Mesenchymal Stem Cells in Craniofacial Defects through (2007)

Mesenchymal stem cells (MSCs) are multipotent cells that can be differentiated into osteoblasts and provide an excellent cell source for bone regeneration and repair. Recently, the canonical Wnt/-catenin signaling pathway has been found to play a critical role in skeletal development and osteogenesis, implying that Wnts can be utilized to improve de novo bone formation mediated by MSCs. However, it is unknown whether noncanonical Wnt signaling regulates osteogenic differentiation. Here, we find that Wnt-4 enhanced in vitro osteogenic differentiation of MSCs isolated from human adult craniofacial tissues and promoted bone formation in vivo. Whereas Wnt-4 did not stabilize -catenin, it activated p38 MAPK in a novel noncanonical signaling pathway. The activation of p38 was dependent on Axin and was required for the enhancement of MSC differentiation by Wnt-4. Moreover, using two different models of craniofacial bone injury, we found that MSCs genetically engineered to express Wnt-4 enhanced osteogenesis and improved the repair of craniofacial defects in vivo. Taken together, our results reveal that noncanonical Wnt signaling could also play a role in osteogenic differentiation. Wnt-4 may have a potential use in improving bone regeneration and repair of craniofacial defects.
Germline and somatic mutations in STXBP1 with diverse neurodevelopmental phenotypes (2017)

<i>STXBP1</i> mutations are an important cause of epilepsy and are also rarely associated with ASD. In a case with histologically proven FCD, an <i>STXBP1</i> somatic mutation was identified, suggesting a role in its etiology. Removing such tissue may be curative for <i>STXBP1</i>-related epilepsy.
Prone Transpsoas Technique for Simultaneous Single-Position Access to the Anterior and Posterior Lumbar Spine (2020)

The authors' early experience with the described PTP technique suggests it is not only feasible but offers some advantages, as it allows for single-position surgery maximizing both anterior and posterior column access and corrective techniques. Further follow-up studies of this technique are ongoing.
Detecting active pulmonary tuberculosis with a breath test using nanomaterial-based sensors (2014)

To the Editor: 

Detecting active tuberculosis (TB) remains a major global public health challenge [1]. The tuberculin skin test does not distinguish latent from active TB [2]. The interferon-γ release assays have similar limitations [3]. Acid-fast bacilli staining of sputum has a high false-negative rate (up to 50%) [4]. Nucleic acid amplification tests (NAATs), such as GeneXpert MTB/RIF (Cepheid, Sunnyvale, CA, USA), are accurate but require a good infrastructure and the necessity to obtain a good quality sputum sample, which is often unobtainable in more than a third of HIV-infected persons [5, 6].

Given these unmet needs, we explored the use of a novel, rapid, simple and inexpensive point-of-care test for the diagnosis of TB [7]. The approach is based on the detection of volatile organic compounds (VOCs) that are emitted from infected cells and released in exhaled breath [8, 9]. Using gas chromatography linked with mass spectrometry, researchers have previously reported identification of TB-related VOCs in the exhaled breath, though there has been low accuracy in detection (80–85%) [10]. In this study, we explore the possibility of active TB detection via the analysis of exhaled breath using a novel technology of organically modified nanomaterial-based sensors. Such cross-reactive sensors are highly sensitive to the collective changes in the VOCs spectrum [8].

Therefore, we designed a case–control study, in which breath and sputum sampling was performed in 210 adult participants, after informed consent, at three sites in Cape Town, South Africa, between November 2011 and March 2012. The study population consisted of two main subgroups. The first subgroup included those in …
Development of Biaxially Stretched Film for Flexible Printed Circuit Boards (1995)

A biaxially stretched film of BEK, a new engineering plastic with high heat resistance ( T g : 181° C, T m : 364° C) and chemical resistance, was developed as a base film for flexible printed circuit boards. Its heat shrinkage percentage at 260° C and the coefficient of thermal expansion below T g were decreased to below 0.1%, and 3.3×10 -5 /° C, respectively. The process of determining stretching and heat setting conditions for film formation with a role stretcher and a tenter is reported.
QAM-FBMC system with a robust prototype filter in multipath fading channels (2014)

We propose a filter-bank multicarrier (FBMC) system to transmit quadrature amplitude modulation (QAM), which can suppress sidelobe level of the odd prototype filter. We present low-pass filtering method obtaining frequency confinement property for the odd filter. Bit error rate (BER) performance shows that the proposed odd filter can enhance the FBMC system in multipath fading channels compared to the conventional QAM-FBMC system.
Ultra-thin near infrared camera enabled by a flat multi-level diffractive lens (2019)

In Opt. Lett.44, 5450 (2019)OPLEDP0146-959210.1364/OL.44.005450, there were errors in the author listing and in one figure.
Broadband wavelength shifter for picosecond optical pulses at 1.5 μm (1993)

The Letter demonstrates the 5.0 nm wavelength conversion of a modelocked optical pulse train by cavity-enhanced high nondegenerate four-wave mixing in a 1.53 μm injectionlocked bulk InGaAsP V-groove laser. Input pulses having 17 ps duration are broadened to 61 ps due to the filtering imposed by the mixing laser. The output pulse broadening is shown to depend on the mixing laser bias current.
Novel phages of healthy skin metaviromes from South Africa (2018)

Recent skin metagenomic studies have investigated the harbored viral diversity and its possible influence on healthy skin microbial populations, and tried to establish global patterns of skin-phage evolution. However, the detail associated with the phages that potentially play a role in skin health has not been investigated. While skin metagenome and -metavirome studies have indicated that the skin virome is highly site specific and shows marked interpersonal variation, they have not assessed the presence/absence of individual phages. Here, we took a semi-culture independent approach (metaviromic) to better understand the composition of phage communities on skin from South African study participants. Our data set adds over 130 new phage species of the skin to existing databases. We demonstrated that identical phages were present on different individuals and in different body sites, and we conducted a detailed analysis of the structural organization of these phages. We further found that a bacteriophage related to the Staphylococcus capitis phage Stb20 may be a common skin commensal virus potentially regulating its host and its activities on the skin.
ChemInform Abstract: Novel Angular Tricyclic Inhibitors of Thymidylate Synthase. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A High Throughput Luminescent Assay for Glycogen Synthase Kinase-3 β Inhibitors (2007)

A high throughput luminescent assay based on the Kinase-Glo() system (Promega, Madison, WI) has been developed for screening against glycogen synthase kinase-3beta (GSK-3beta). Careful optimization of assay parameters allowed us to develop a robust, reproducible, and sensitive assay. Its usefulness has been demonstrated in a high throughput screening run when screening 55,000 compounds. This campaign yielded five chemical classes of hits, including several highly potent GSK-3beta inhibitors.
A Machine Learning Method for State of Charge Estimation in Lead-Acid Batteries for Heavy-Duty Vehicles (2021)

Abstract In the automotive framework, an accurate assessment of the State of Charge (SOC) in lead-acid batteries of heavy-duty vehicles is of major importance. SOC is a crucial battery state that is non-observable. Furthermore, an accurate estimation of the battery SOC can prevent system failures and battery damage due to a wrong usage of the battery itself. In this context, a technique based on machine learning for SOC estimation is presented in this study. Thus, this method could be used for safety and performance monitoring purposes in electric subsystem of heavy-duty vehicles. The proposed approach exploits a Genetic Algorithm (GA) in combination with Artificial Neural Networks (ANNs) for SOC estimation. Specifically, the training parameters of a Nonlinear Auto-Regressive with Exogenous inputs (NARX) ANN are chosen by the GA-based optimization. As a consequence of the GA-based optimization, the ANN-based SOC estimator architecture is defined. Then, the proposed SOC estimation algorithm is trained and validated with experimental datasets recorded during real driving missions performed by a heavy-duty vehicle. An equivalent circuit model representing the retained lead-acid battery is used to collect the training, validation and testing datasets that replicates the recorded experimental data related to electrical consumers and the cabin systems or during overnight stops in heavy-duty vehicles. This article illustrates the architecture of the proposed SOC estimation algorithm along with the identification procedure of the ANN parameters with GA. The method is able to estimate SOC with a low estimation error, being suitable for deployment on common on-board Battery Management Systems (BMS).
Changes in Gastric Function and Healing of Chronic Gastric Ulcers in Aged Rats (1995)

The present study was designed to determine the relationship between changes in gastric function caused by aging and the healing of gastric ulcers. Male Fischer-344 rats (young, 2 months; aged, 24-26 months) were used. Gastric ulcers were induced by luminal application of an acetic acid solution (60%, 0.2 ml, 45 sec). The basal and histamine-stimulated gastric acid secretions in aged animals were significantly lower than those in young animals. However, the serum gastrin levels were almost the same in the two groups. Gastric mucosal blood flow and mucosal cell proliferation were also decreased in aged animals. Gastric contractile activity induced by electrical vagal stimulation was almost the same in the two groups, while the gastric relaxative response was significantly reduced in aged animals. The development and healing rate of gastric ulcers in aged animals were almost the same as those in young animals. Histologically, regeneration of the ulcerated mucosa was significantly reduced and tissue contraction occurred in aged animals, as compared to in young animals. We concluded that aging had little or no influence on the development and healing rate of gastric ulcers in rats, but the quality of ulcer healing was quite different between young and aged animals, probably resulting from various gastric dysfunctions related to ulcer healing.
Health technology assessment in interventional electrophysiology and device therapy: a position paper of the European Heart Rhythm Association (2013)

not available
Diagnosis and Treatment of Obstructive Sleep Apnea in a Stroke Rehabilitation Unit (2002)

Obstructive sleep apnea can be diagnosed in approximately 60% of stroke survivors in the postacute period and has been found to be associated with increased mortality and a worse functional outcome at 3 and 12 mo after discharge. In this study, 38 patients undergoing rehabilitation after stroke underwent sleep studies by using the AutoSet Portable II Plus device; obstructive sleep apnea was found in 18 of the patients, and five consecutively diagnosed patients were treated on the ward with nasal continuous positive airway pressure. The research has shown that it is feasible to routinely implement a diagnostic and therapeutic approach to sleep apnea on the rehabilitation ward, which is hoped to have a positive influence on mortality, functional outcome, and secondary prevention.
Statistical models for physically derived target sub-spaces (2006)

Traditional approaches to hyperspectral target detection involve the application of detection algorithms to atmospherically compensated imagery. Rather than compensate the imagery, a more recent approach uses physical models to generate target sub-spaces. These <i>radiance </i>sub-spaces can then be used in an appropriate detection scheme to identify potential targets. The generation of these sub-spaces involves some <i>'a priori</i> knowledge of data acquisition parameters, scene and atmospheric conditions, and possible calibration errors. Variation is allowed in the model since some parameters are difficult to know accurately. Each vector in the subspace is the result of a MODTRAN simulation coupled with a physical model. Generation of large target spaces can be computationally burdensome. This paper explores the use of statistical methods to describe such target spaces. The statistically modeled spaces can then be used to generate arbitrary radiance vectors to form a sub-space. Statistically modeled target sub-spaces, using limited training samples, were found to accurately resemble MODTRAN derived radiance vectors.
A new approach to cyclitols based on rabbit-muscle aldolase (RAMA) (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA new approach to cyclitols based on rabbit-muscle aldolase (RAMA)Walther Schmid and George M. WhitesidesCite this: J. Am. Chem. Soc. 1990, 112, 26, 9670–9671Publication Date (Print):December 1, 1990Publication History Published online1 May 2002Published inissue 1 December 1990https://pubs.acs.org/doi/10.1021/ja00182a054https://doi.org/10.1021/ja00182a054research-articleACS PublicationsRequest reuse permissionsArticle Views209Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts