gebhart/patrepeval huggingface dataset:
Inter-frequency radio signal quality prediction for handover, evaluated\n in 3GPP LTE (2019)

Radio resource management in cellular networks is typically based on device\nmeasurements reported to the serving base station. Frequent measuring of signal\nquality on available frequencies would allow for highly reliable networks and\noptimal connection at all times. However, these measurements are associated\nwith costs, such as dedicated device time for performing measurements when the\ndevice will be unavailable for communication. To reduce the costs, we consider\npredictions of inter-frequency radio quality measurements that are useful to\nassess potential inter-frequency handover decisions. In this contribution, we\nhave considered measurements from a live 3GPP LTE network. We demonstrate that\nstraightforward applications of the most commonly used machine learning models\nare unable to provide high accuracy predictions. Instead, we propose a novel\napproach with a duo-threshold for high accuracy decision recommendations. Our\napproach leads to class specific prediction accuracies as high as 92% and 95%,\nstill drastically reducing the need for inter-frequency measurements.\n
TCB subsets: the next step (2003)

The advantages of TCB (trusted computing base) subsetting for building multilevel database systems are discussed, and the architectural impact on the database system when the TCB subsetting approach is used in a real implementation is described. Particular attention is given to such areas of difficulty as concurrency controls, recovery management, and buffer management. In discussing implications for the architecture of the database system, it is noted that the standard ORACLE database system already supports those architectural features that are required, and ORACLE is proceeding with product development and product evaluation projects to extend the promise of TCB subsetting to commercially available ORACLE RDBMS (relational database management system) products on a wide variety of platforms. The SeaView prototype takes advantage of the architectural features of ORACLE with a TCB subsetting approach to achieve a class A1 system that reuses existing TCB and database technology.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Abstract 192: Targeting stearoyl CoA desaturase 1 (SCD1) in hepatobilliary carcinoma (2017)

Abstract Background: The paucity of effective therapeutic agents for hepatocellular cancer (HCC) underscores the critical need for more effective therapeutic strategies. Recent studies indicate lipid biosynthesis and desaturation is required for HCC survival. Targeting these may prove beneficial because such changes contribute to therapeutic resistance. Stearoyl CoA desaturase (SCD1), a key mediator of fatty acid (FA) biosynthesis and rate-limiting in conversion of saturated fatty acids (SFAs) to mono-unsaturated fatty acids (MUFAs), is upregulated in HCC and many other cancers. As such, we therapeutically targeted a novel lipogenic tumor survival mechanism mediated by SCD1 as a means to combat the chemoresistance associated with HCC. In so doing, we evaluated a novel lead SCD1 inhibitor in HCC. Methods: Paraffin embedded patient HCC tissues were examined for SCD1 expression. Using combined computational and synthetic chemistry approaches, we synthesized four novel specific SCD1 inhibitors with SSI-4 being the lead SCD1 inhibitor. HCC cell lines were examined using proliferation assays for response to SSI-4. IC50 concentrations for blocking SCD1 enzyme activity was determined. Blood half-life and bioavailability of single dose SSI-4 was determined. Mechanisms of action of SCD1 were examined that included Endoplasmic reticulum (ER) stress. In vivo, antitumor activity was determined using HCC patient derived xenograft (PDX) mouse models. Results: We identified elevated SCD1 mRNA and protein in HCCs tissues. SSI-4 dose-dependently inhibits cell proliferation in HCC cell lines with specificity demonstrated by oleic acid (MUFA) co-culture. Single dose oral gavage SSI-4 demonstrated a half-life of ~4 hours and excellent oral bioavailability. SSI-4 was well tolerated with long-term daily dosing. SSI-4 treatment of HCC cells and tumors led to endoplasmic reticulum (ER) stress followed by apoptotic cell death. Single agent SSI-4 demonstrated antitumor activity in HCC PDX mouse models with suppression of ER stress regulated proteins. Conclusions: Targeting a novel lipid metabolic pathway in HCC may provide effective therapy for aggressive HCC. Citation Format: John Alton Copland, Laura A. Marlow, Ilah Bok, James L. Miller, Matsuda Akiko, Yan W. Asmann, Vivekananda Sarangi, Steven R. Alberts, Kabir Mody, Lewis R. Roberts, Mark J. Truty, Tushar C. Patel. Targeting stearoyl CoA desaturase 1 (SCD1) in hepatobilliary carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 192. doi:10.1158/1538-7445.AM2017-192
The Density Distribution in Pressed Charges. An analytical approach (1989)

Abstract High performance shaped charges require a perfect rotational symmetry and homogenity in structure. Therefore the density distribution of the explosive inside the charge has to meet the same specifications in order to obtain the desired geometry of the detonation wave. In this paper we present an analytical model which describes the density inside the charge as a function of the pressure and the friction between the tool surface and the granulate. The density distribution inside a cylindrical body has been calculated. The comparison with experimental data shows a good agreement.
Use of the p-nitrobenzyloxycarbonyl group as an orthogonal amine protecting group in the synthesis of β-GlcNAc terminating glycosides (1997)

The p-nitrobenzyloxycarbonyl group serves as a participating group in the stereoselective formation of 2-amino-β-glucosides and as an N-protecting group which can be readily removed either by hydrogenolysis or by reaction with sodium dithionite under neutral conditions.
Oxidation Number Estimation of Ca in Ca-N Compounds from Ca K-edge XANES Spectra (2017)

Abstract XANES spectra were measured on Ca K-edge for Ca2N, Ca3N2, Ca2NH, CaNH, and Ca(NH2)2. Ca2N and Ca3N2 show the lowest edge positions, while Ca(NH2)2 the highest. The relationship between the edge positions and electron biasing around Ca in the compounds is discussed and the oxidation numbers are estimated.
Feedback scaling for downlink comp with orthogonal and non-orthogonal waveforms (2014)

In this paper, we study the problem of limited feedback and channel aging in the context of Filter Bank Multi-Carrier (FBMC) modulation for multi-user downlink cooperation between cells. Specifically, we investigate the robustness of FBMC in downlink Coordinated Multi Point (CoMP) scenarios with respect to standard compliant feedback link and MAC related asynchronisms such as outdated channel state information, considering also different user velocities. Previous work showed that FBMC has a better packet error rate (PER) performance compared to OFDM, leading to improved throughput performance in system level simulations. These results are shown by system simulations to be robust in scenarios with limited feedback and channel aging as well. We also provide an analytical investigation.
Angiotensin III Stimulates Aldosterone Secretion from Adrenal Gland Partially via Angiotensin II Type 2 Receptor But Not Angiotensin II Type 1 Receptor (2011)

Angiotensin II (Ang II) and Ang III stimulate aldosterone secretion by adrenal glomerulosa, but the angiotensin receptor subtypes involved and the effects of Ang IV and Ang (1-7) are not clear. In vitro, different angiotensins were added to rat adrenal glomerulosa, and aldosterone concentration in the medium was measured. Ang II-induced aldosterone release was blocked (30.3 ± 7.1%) by an Ang II type 2 receptor (AT2R) antagonist, PD123319. Candesartan, an Ang II type 1 receptor (AT1R) antagonist, also blocked Ang II-induced aldosterone release (42.9 ± 4.8%). Coadministration of candesartan and PD123319 almost abolished the Ang II-induced aldosterone release. A selective AT2R agonist, CGP42112, was used to confirm the effects of AT2R. CGP42112 increased aldosterone secretion, which was almost completely inhibited by PD123319. In addition to Ang II, Ang III also induced aldosterone release, which was not blocked by candesartan. However, PD123319 blocked 22.4 ± 10.5% of the Ang III-induced aldosterone secretion. Ang IV and Ang (1-7) did not induce adrenal aldosterone secretion. In vivo, both Ang II and Ang III infusion increased plasma aldosterone concentration, but only Ang II elevated blood pressure. Ang IV and Ang (1-7) infusion did not affect blood pressure or aldosterone concentration. In conclusion, this report showed for the first time that AT2R partially mediates Ang III-induced aldosterone release, but not AT1R. Also, over 60% of Ang III-induced aldosterone release may be independent of both AT1R and AT2R. Ang III and AT2R signaling may have a role in the pathophysiology of aldosterone breakthrough.
Unimolecular Combination of an Atom Transfer Radical Polymerization Initiator and a Lactone Monomer as a Route to New Graft Copolymers (1999)

The synthesis, polymerization, and copolymerization of a new cyclic ester, γ-(2-bromo-2-methyl propionyl)-ε-caprolactone (3), containing a pendent-activated alkyl bromide functional group is described. This new compound serves as both a monomer for "living" ring-opening polymerization (ROP) as well as an initiator for the controlled atom transfer radical polymerization (ATRP). Three distinctive routes to poly(ε-caprolactone)−graft−poly(methyl methacrylate) copolymers were surveyed by either sequential or concurrent living polymerization procedures. The first approach involves the ROP of ε-caprolactone with various compositions of 3, followed by the polymerization of methyl methacrylate via ATRP from the activated alkyl bromide sites along the polyester backbone. Alternatively, α-lactone functional methyl methacrylate macromonomers were prepared by ATRP of methyl methacrylate initiated from 3. The macromonomers were copolymerized with ε-caprolactone via ROP to form the target graft copolymers. Finally, the graft copolymers could be prepared in a simple one-step approach by the concurrent polymerization of ε-caprolactone, 3, and methyl methacrylate together with the appropriate initiator for the ROP and the catalyst for the ATRP. The new monomer enabled new graft copolymers having an aliphatic polyester backbone with poly(methyl methacrylate) grafts of controlled molecular weight and narrow polydispersities (∼1.3).
Deceiving Google's Cloud Video Intelligence API Built for Summarizing Videos (2017)

Despite the rapid progress of the techniques for image classification, video annotation has remained a challenging task. Automated video annotation would be a breakthrough technology, enabling users to search within the videos. Recently, Google introduced the Cloud Video Intelligence API for video analysis. As per the website, the system can be used to "separate signal from noise, by retrieving relevant information at the video, shot or per frame" level. A demonstration website has been also launched, which allows anyone to select a video for annotation. The API then detects the video labels (objects within the video) as well as shot labels (description of the video events over time). In this paper, we examine the usability of the Google's Cloud Video Intelligence API in adversarial environments. In particular, we investigate whether an adversary can subtly manipulate a video in such a way that the API will return only the adversary-desired labels. For this, we select an image, which is different from the video content, and insert it, periodically and at a very low rate, into the video. We found that if we insert one image every two seconds, the API is deceived into annotating the video as if it only contained the inserted image. Note that the modification to the video is hardly noticeable as, for instance, for a typical frame rate of 25, we insert only one image per 50 video frames. We also found that, by inserting one image per second, all the shot labels returned by the API are related to the inserted image. We perform the experiments on the sample videos provided by the API demonstration website and show that our attack is successful with different videos and images.
Failure mode analysis of silicon-based intracortical microelectrode arrays in non-human primates (2013)

This is the first long-term failure mode analysis of an emerging BCI technology in a large series of non-human primates. The classification system introduced here may be used to standardize how neuroprosthetic failure modes are evaluated. The results demonstrate the potential for these arrays to record for many years, but achieving reliable sensors will require replacing connectors with implantable wireless systems, controlling the meningeal reaction, and improving insulation materials. These results will focus future research in order to create clinical neuroprosthetic sensors, as well as valuable research tools, that are able to safely provide reliable neural signals for over a decade.
Intrusion Detection With Support Vector Machines and Generative Models (2002)

This paper addresses the task of detecting intrusions in the form of malicious attacks on programs running on a host computer system by inspecting the trace of system calls made by these programs.We use 'attack-tree' type generative models for such intrusions to select features that are used by a Support Vector Machine Classifier.Our approach combines the ability of an HMM generative model to handle variable-length strings, i.e. the traces, and the non-asymptotic nature of Support Vector Machines that permits them to work well with small training sets.
Fluorinated Liquid Crystals (2022)

Abstract The element fluorine is essential for the operation of modern liquid crystal displays (LCDs). It is “visible” to billions of people who mostly are unaware of its presence—in the same room, their pockets, and very often close to their faces. Fluorine makes liquid crystals polar, so they can be switched in an electric field. It imparts conformational rigidity, chemical stability, low polarizability, and viscosity—all crucial factors for the smooth operation of the state‐of‐the‐art LCDs. This chapter presents the syntheses and structure–property relationships of a wide variety of fluorinated materials. Their uses range from standard LCDs to yet unrealized technologies such as Blue Phase displays and future applications of the newly discovered ferroelectric nematic phases. The design of new compounds is often based on rational arguments and a detailed analysis of the physical properties expected for a given structural feature. This is then realized by employing sophisticated synthetic methods unheard of in standard materials chemistry. Even after four decades of research, there is still room for fascination, progress, and surprises.
Electrically floating conductivity detection system for capillary electrophoresis (1998)

A conductivity detector is designed for capillary electrophoresis in which the detection electronics are isolated and float with the separation voltage applied to the capillary. This design minimizes the detrimental effect of the high voltage to the detection system and is powered using a battery. A simple arrangement is fabricated for the conductivity measurement electrodes. The electrical signal generated at these electrodes is carried through the floating electronics and then transmitted to a data-acquisition computer through a optical (infrared) serial link. As a preliminary demonstration, a sample solution containing three alkali metal ions is analyzed. The detection limits for the ions are about 2·10−6 M.
Nano-Grating Force Sensor for Measurement of Neuron Membrane Characteristics Under Growth and Cellular Differentiation (2007)

We fabricated single-layer pitch-variable diffractive nanogratings on silicon nitride probe using e-beam lithography and subsequent pattern transfer techniques. The nanogratings consist of flexure folding beams suspended between two parallel cantilevers of known stiffness. The probe displacement, therefore the force, can be measured through grating transmission spectrum. We measured the mechanical membrane characteristics of PC 12 cells using the force sensors with displacement range of 10 μm and force sensitivity 8 μN/μm. Young's moduli of 425±30 Pa are measured with membrane deflection of 1% for PC 12 cells cultured on polydimethylsiloxane(PDMS) substrate coated with collagen or laminin in Ham's F-12K medium. We have also observed stimulation of directed neurite contraction up to 6 μm on extended probing for a time period of 30 minutes.
A Session-Based Cross-Layer Approach for Seamless Connectivity in Next-Generation Mobile Networks (2020)

The Fifth Generation (5G) network provides a platform for emerging technologies such as vehicular communication, massive Internet of Things (IoT), and tactile internet. It is paving the way to a modern autonomous industry with mobility as a key requirement to achieve seamless end-to-end connectivity. But the current transport layer is not well equipped with the evolving lower layers to deal with the dynamics of the network conditions during mobility. The variation in network conditions and frequent disturbance in lower layers due to handovers causes performance degradation in the transport layer. Hence, we propose a novel solution called ID oriented Socket Layer (IoSL), an end-to-end solution for futuristic applications. It is an ID-based software solution that maintains a unique identifier among the transport layer connections to provide seamless connectivity to the end devices. During user mobility and frequent handover scenarios, it communicates with the lower layers and effectively controls the transport layer for achieving improved Quality-of-Service (QoS) with enhanced user experience. We prototyped IoSL in mobile devices and evaluated the performance using the ns-3 simulator as well as live-air experiments. The experiments are conducted using Wi-Fi and 5G networks, and the results show a significant reduction in reconnection latencies around 33% and improved end-user throughput by up to 16%.
Analysis of Magnetization Transfer Ratio Measurements at 3T using Multiple-Acquisition Balanced SSFP (2011)

Recently, it has been shown that fast magnetization transfer (MT) scans based on balanced steady-state free precession (bSSFP) with RF pulse modification achieve high SNR and high reproducibility at 1.5T. At 3T, combination of multiple, phase-cycled, bSSFP scans might be required to overcome limitations from off-resonance artifacts. In this study, different recombination methods for the generation of accurate magnetization transfer ratio (MTR) maps were analyzed. Maximum intensity projection removes off-resonance artifacts without significant MTR modification, whereas sum-of-squares and weighted-combination bSSFP yield reduced MTR values.
7 W average power second harmonic generation of quasi-CW Yb source in MgO-doped stoichiometric PPLT (2005)

Application of stoichiometric MgO:PPLT to single-pass, 57%-efficient, 7.05 W average-power SHG of a quasi-CW, single-mode Yb-doped fiber source is demonstrated. Peak-power-density control, reduced photorefraction and nonlinear absorption of sPPLT resulted in near diffraction-limited SH beam quality.
ChemInform Abstract: Design, Synthesis, and Pharmacological Evaluation of Azetedine and Pyrrolidine Derivatives as Dual Norepinephrine Reuptake Inhibitors and 5‐HT1A Partial Agonists. (2011)

Abstract Optimization of a recently developed dual norepinephrine reuptake inhibitor and serotonin 1A partial agonist leads to the identification of an oxygen‐linked azetidine (I) or pyrrolidine derivative (II) as a suitable piperidine A‐ring replacement in this novel biaryl‐ether series.
The PONI-1 parallel-optical link (2003)

A low-cost, surface-mountable parallel-fiber optical link, which employs passive mechanical alignment of its optical elements, is described. The optical links are fabricated as separate transmitter and receiver modules comprised of 8 or 12 channels operating at a maximum rate of 1.25 GBd per channel. The electro-mechanical platform is constructed using materials and techniques originally developed for fabricating tape ball grid array (TBGA) IC packages. Electrical I/O is provided via a 6/spl times/10 solder ball array on 50 mil centers. The modules are designed to operate off of a 3.3 V supply voltage, and to interface with a variety of fiber ribbon connectors.
Dendritic Cell Internalization of α-Galactosylceramide from CD8 T Cells Induces Potent Antitumor CD8 T-cell Responses (2011)

Dendritic cells (DC) present α-galactosylceramide (αGalCer) to invariant T-cell receptor-expressing natural killer T cells (iNKT) activating these cells to secrete a variety of cytokines, which in turn results in DC maturation and activation of other cell types, including NK cells, B cells, and conventional T cells. In this study, we showed that αGalCer-pulsing of antigen-activated CD8 T cells before adoptive transfer to tumor-bearing mice caused a marked increase in donor T-cell proliferation, precursor frequency, and cytotoxic lymphocyte activity. This effect was interleukin (IL)-2 dependent and involved both natural killer T cells (NKT) and DCs, as mice lacking IL-2, NKTs, and DCs lacked any enhanced response to adoptively transferred αGalCer-loaded CD8 T cells. iNKT activation was mediated by transfer of αGalCer from the cell membrane of the donor CD8 T cells onto the αGalCer receptor CD1d which is present on host DCs. αGalCer transfer was increased by prior activation of the donor CD8 T cells and required AP-2-mediated endocytosis by host DCs. In addition, host iNKT cell activation led to strong IL-2 synthesis, thereby increasing expansion and differentiation of donor CD8 T cells. Transfer of these cells led to improved therapeutic efficacy against established solid tumors in mice. Thus, our findings illustrate how αGalCer loading of CD8 T cells after antigen activation in vitro may leverage the therapeutic potential of adoptive T-cell therapies.
Chimie des processus biologiques : une introduction (2009)

La vie dépend de la capacité des organismes vivants à utiliser efficacement le potentiel chimique de leur environnement : le soleil, pour l’énergie, et un certain nombre de molécules accumulées à la surface de la terre (eau, oxygène, dioxyde de carbone, azote, etc.). Pour en tirer parti, il faut les activer, et cela nécessite des modifications électroniques profondes que seuls les ions métalliques permettent. Les métalloenzymes qui réalisent ces activations sont véritablement extraordinaires, et leurs mécanismes d’action d’une très grande subtilité. À l’interface de la chimie et de la biologie, la chimie bio-inorganique est aujourd’hui en pleine expansion. Elle est née du constat relativement récent que la vie n’est pas seulement organique mais aussi « minérale » : il n’y a pas de vie sans métaux.
An Ultra Low-Power Non-Volatile Memory Design Enabled by Subquantum Conductive-Bridge RAM (2016)

Conductive-bridge RAM (CBRAM) memory cells offer speed, voltage, and energy advantages over floating gate flash cells. Here, we describe a memory design which carries these cell-level advantages up to the product level, achieving 100x lower read and write power and 10x lower standby power than typical flash-based designs.