gebhart/patrepeval huggingface dataset:
Dialog+ in Broadcasting: First Field Tests Using Deep-Learning-Based Dialogue Enhancement (2021)

Difficulties in following speech due to loud background sounds are common in broadcasting. Object-based audio, e.g., MPEG-H Audio solves this problem by providing a user-adjustable speech level. While object-based audio is gaining momentum, transitioning to it requires time and effort. Also, lots of content exists, produced and archived outside the object-based workflows. To address this, Fraunhofer IIS has developed a deep-learning solution called Dialog+, capable of enabling speech level personalization also for content with only the final audio tracks available. This paper reports on public field tests evaluating Dialog+, conducted together with Westdeutscher Rundfunk (WDR) and Bayerischer Rundfunk (BR), starting from September 2020. To our knowledge, these are the first large-scale tests of this kind. As part of one of these, a survey with more than 2,000 participants showed that 90% of the people above 60 years old have problems in understanding speech in TV "often" or "very often". Overall, 83% of the participants liked the possibility to switch to Dialog+, including those who do not normally struggle with speech intelligibility. Dialog+ introduces a clear benefit for the audience, filling the gap between object-based broadcasting and traditionally produced material.
Access lens (2013)

Gesture-based touch screen user interfaces, when designed to be accessible to blind users, can be an effective mode of interaction for those users. However, current accessible touch screen interaction techniques suffer from one serious limitation: they are only usable on devices that have been explicitly designed to support them. Access Lens is a new interaction method that uses computer vision-based gesture tracking to enable blind people to use accessible gestures on paper documents and other physical objects, such as product packages, device screens, and home appliances. This paper describes the development of Access Lens hardware and software, the iterative design of Access Lens in collaboration with blind computer users, and opportunities for future development.
‘The liquid choirs of his tribes’: Dylan Thomas as icon, influence and intertext (2013)

This chapter argues that Thomas' poetry has been a kind of secret, but powerful, leaven in US and British poetry over the last fifty years, and that he continues to haunt the fraught zone between traditionalist and alternative poetry in Britain. His impact on the poetic landscape resembles that of some huge Jurassic meteor — a vast, weathered crater, invisible at ground level, but unmissable from the air, and requiring a major rethink of the standard narrative of events.
Via-middle through-silicon via with integrated airgap to zero TSV-induced stress impact on device performance (2013)

In the study, we report for the first time a novel concept for the mitigation of the TSV-induced stress on the CMOS device performance. This solution consists in selectively integrating an airgap at the time of via-middle TSV processing. In addition to the expected benefits in term of stress management, this new approach is also cost effective, as the TSV processing steps, such as deep silicon etching, Cu electroplating, and chemical mechanical polishing remain unchanged. The processing development and the results of the morphological and electrical characterization are given in details in this study. All in all, TSV with integrated airgap is a very versatile building block for TSV integration in presence of stress sensitive next generation of CMOS devices.
Nonlocal Optical Phenomena in Metamaterials (2012)

We demonstrate excitation of additional electromagnetic waves in plasmonic nanorod metamaterials. These waves arising from a nonlocal optical response of metamaterial results in strongly enhanced ultrafast nonlinear response.
Electronic and Steric Ligand Effects in the Radical Polymerization of Vinyl Acetate Mediated by β‐Ketoiminate Complexes of Cobalt(II) (2009)

Complexes Co[OC(Ph)CHC(Me)NAr](2) [Ar=Ph, 1; o,o'-C(6)H(3)Me(2) (Xyl), 2; p-C(6)H(4)CF(3), 3] are tested in the polymerization of vinyl acetate (VAc) initiated by V-70 (0.8 equiv) at 30 degrees C. Polymerization occurs without any notable induction time yielding PVAc with relatively low polydispersity, but with higher than expected M(n) values, which indicates inefficient trapping processes. The apparent polymerization rate constant varies in the order 2>1>3. Controlled polymer growth is also observed when the polymerization is conducted in the presence of a much higher V-70/1 ratio, demonstrating that this system can also function as a transfer agent in a degenerative transfer process. Competition between chain growth and catalyzed chain transfer (CCT) is also observed, the latter prevailing at higher temperatures. Comparison of these results with previous reports on bis(beta-diketonato) complexes allows a separate assessment of ligand electronic and steric effects in the ability to control polymerization.
Search for high-mass Zγ resonances in e+e−γ and μ + μ −γ final states in proton-proton collisions at s = 8 $$ \sqrt{s}=8 $$ and 13 TeV (2017)

This paper describes the search for a high-mass narrow-width scalar particle decaying into a Z boson and a photon. The analysis is performed using proton-proton collision data recorded with the CMS detector at the LHC at center-of-mass energies of 8 and 13 TeV, corresponding to integrated luminosities of 19.7 and 2.7 fb -1 , respectively. The Z bosons are reconstructed from opposite-sign electron or muon pairs. No statistically significant deviation from the standard model predictions has been found in the 200-2000 GeV mass range. Upper limits at 95% confidence level have been derived on the product of the scalar particle production cross section and the branching fraction of the Z decaying into electrons or muons, which range from 280 to 20 fb for resonance masses between 200 and 2000 GeV.
Plastic Deformations of Carbon Nanotubes (1998)

Although the elastic properties of a carbon nanotube are nearly independent of wrapping indices, we show that the onset of plastic deformation depends very strongly on the wrapping index. An $(n,0)$ nanotube has an elastic limit nearly twice that of an $(n,n)$ tube with the same radius. Such great variation has important consequences for structural applications of carbon nanotubes. In addition, the remnant bond rotations remaining after strain release strongly affect the electronic structure of the distorted nanotube.
RETRACTED: Pinostrobin ameliorates lipopolysaccharide (LPS)-induced inflammation and endotoxemia by inhibiting LPS binding to the TLR4/MD2 complex (2022)

Pinostrobin is a natural flavonoid with valuable pharmacological properties, including anti-cancer, anti-viral, and anti-oxidant activities. However, the anti-inflammatory effects of pinostrobin have not been well studied. In this study, we investigated whether pinostrobin attenuates lipopolysaccharide (LPS)-induced inflammation and endotoxemia. Additionally, the target molecule of pinostrobin was identified through molecular docking simulation. Pinostrobin decreased LPS-induced nitric oxide (NO) and prostaglandin E<sub>2</sub> production, and reduced the expression of inducible NO synthase and cyclooxygenase-2. Furthermore, pinostrobin inhibited the production of proinflammatory cytokines, including interleukin-12 and tumor necrosis factor-α in LPS-stimulated RAW 264.7 macrophages accompanied by inhibiting nuclear translocation of nuclear factor-κB. The anti-inflammatory effect of pinostrobin was further confirmed in LPS-microinjected zebrafish larvae by diminishing the recruitment of macrophages and neutrophils, and proinflammatory gene expression. Moreover, LPS-microinjected zebrafish larvae showed a decrease in heart rate and an increase in mortality and abnormalities. However, pinostrobin significantly attenuated these adverse effects. Molecular docking showed that pinostrobin fits into myeloid differentiation factor (MD2) and Toll-like receptor 4 (TLR4) with no traditional hydrogen bonds (pose 1). The 2D ligand interaction diagram showed that pinostrobin forms a carbon hydrogen bond with LYS89 in MD2 and many non-covalent interactions, including π-alkyl or alkyl and van der Waals interactions, indicating that pinostrobin hinders LPS binding between MD2 and TLR4 and consequently inhibits TLR4/MD2-mediated inflammatory responses. These data suggest that pinostrobin attenuates LPS-induced inflammation and endotoxemia by binding to the TLR4/MD2 complex.
Demand Side Management via prosumer interactions in a smart city energy marketplace (2011)

Future smart cities are expected to be very large and complex ecosystems, where interactions among the various involved entities may lead to emergent behaviours (system of systems characteristic). Managing better the energy footprint is one of those challenging goals, and the smartgrid may provide a key tool in achieving that. We expect that smart city neighbourhoods will be more autonomous and able to manage more efficiently and dynamically their energy by taking into consideration local resources, prosumption and needs of their stakeholders. Additionally they will be able to interact with each-other and enable the smart city to dynamically take advantage of its optimal resource usage. We explore here directions that we follow in order to realize this view with the help of the smartgrid infrastructure, prosumer interactions, enterprise energy services and neighbourhood energy marketplaces.
GENI Design Principles (2006)

The Global Environment for Network Innovations is a major planned initiative of the US National Science Foundation to build an open, large-scale, realistic experimental facility for evaluating new network architectures. The facility's goal is to change the way we design networked and distributed systems, creating over time new paradigms that integrate rigorous theoretical understanding with compelling and thorough experimental validation. The research that GENI enables can lead to a future Internet that is more secure, available, manageable, and efficient, and better at handling mobile nodes. GENI is intended to support two general kinds of activities: running controlled experiments to evaluate design, implementation, and engineering choices; and deploying prototype systems and learning from observations of how they behave under real usage
Mechanical Stimulation Induced Elastogenesis in Collagenous Scaffolds Seeded With Bladder Smooth Muscle Cells (2008)

The most successful approaches to tissue engineering the urinary bladder utilize biodegradable scaffolds seeded with autologous cells. Although this technique has proven successful in increasing bladder capacity, problems remain with lack of proper tissue organization post-implantation, impairing the bladder’s ability to maintain its full function. Small intestinal submucosa (SIS) has been utilized previously to engineer the urinary bladder wall with and without cell seeding.
Artificial Neural Network ANN Approach to Predict Fracture Pressure (2019)

Abstract Fracture pressure is a critical formation condition that affects efficiency and economy of drilling operations. The knowledge of the fracture pressure is significant to control the well. It will assist in avoiding problems associated with drilling operation and decreasing the cost of drilling operation. It is essential to predict fracture pressure accurately prior to drilling process to prevent various issues for example fluid loss, kicks, fracture the formation, differential pipe sticking, heaving shale and blowouts. Many models are used to estimate the fracture pressure either from log information or formation strengths. However, these models have some limitations such as some of the models can only be used in clean shales, applicable only for the pressure generated by under-compaction mechanism and some of them are not applicable in unloading formations. Few papers used artificial intelligence (AI) to estimate the fracture pressure. In this work, a real filed data that contain only the real time surface drilling parameters were utilized by artificial neural network (ANN) to predict the fracture pressure. The results indicated that artificial neural network (ANN) predicted the fracture pressures with an excellent precision where the coefficient of determination (R2) is greater than 0.99. In addition, the artificial neural network (ANN) was compared with other fracture pressure models such as Matthews and Kelly model, which is one of the most used models in the prediction of the fracture pressure in the field. Artificial neural network (ANN) model outperformed the fracture models by a high margin and by its simple prediction of fracture pressure where it can predict the fracture pressure from only the real time surface drilling parameters, which are easily available.
An ADAM10 exosite inhibitor is efficacious in an in vivo collagen-induced arthritis model (2023)

Abstract Rheumatoid arthritis is a systemic autoimmune inflammatory disease which affects millions of people worldwide. There are multiple disease-modifying anti-rheumatic drugs available; however, many of the patients do not respond to any treatment. A disintegrin and metalloproteinase 10 has been suggested as a potential new target for RA due to its role in releasing of multiple pro- and anti-inflammatory factors from the cell surface of cells. In the present study we determined pharmacokinetic parameters and in vivo efficacy of a compound CID3117694 from a novel class of non-zinc-binding inhibitors. Oral bioavailability was demonstrated in blood and synovial fluid after 10mg/kg dose. To test efficacy, we established the collagen-induced arthritis model in mice. CID3117694 was administered orally at 10, 30, and 50 mg/kg/day for 28 days. CID3117694 was able to dose-dependently improve disease score, decrease RA markers in blood and decrease signs of inflammation, hyperplasia, pannus formation, and cartilage erosion in affected joints as compared to the untreated control. Additionally, mice treated with CID 3117694 did not exhibit any clinical signs of distress, suggesting low toxicity. The results of this study suggest that ADAM10 exosite inhibition can be a viable therapeutic approach to RA.
Coordination and reactivity of Cu/sup 2 +/ Cations in mordenite and ZSM-5 (1985)

An ESR study has been made of the localization of Cu/sup 2 +/ cations introduced by exchange into the Na and H forms of mordenite and ZSM-5. It has been shown that in the HM with low degrees of exchange, the Cu/sup 2 +/ cations are localized in isolation, having the coordination of a square pyramid, stable when treated in CO at 400/sup 0/. With increasing exchange in the HM, interacting Cu/sup 2 +/ cations appear; these are reduced in CO at 300-400/sup 0/. In ZSM-5, the fraction of interacting Cu/sup 2 +/ ions is insignificant; and for the isolated Cu/sup 2 +/ cations, two types of coordination are characteristic: square pyramid and plane square. Localization in a plane square is also characteristic for part of the isolated Cu/sup 2 +/ cations in CuNaM. The coordination unsaturation of the isolated Cu/sup 2 +/ cations in these zeolites is confirmed by the strong influence of CO and O/sub 2/ on the hfs of the ESR spectra of the Cu/sup 2 +/ ions. Calcination of the CuM and Cu-ZSM-5 specimens in air at 800/sup 0/ does not lead to aggregation of the isolated Cu/sup 2 +/ ions. Vacuum-baking at 450/sup 0/ doesmore » not bring about reduction of Cu/sup 2 +/ cations in any of the specimens that were investigated.« less
Data from Expression of Adipocyte/Macrophage Fatty Acid–Binding Protein in Tumor-Associated Macrophages Promotes Breast Cancer Progression (2023)

&lt;div&gt;Abstract&lt;p&gt;Tumor-associated macrophages (TAM) play a critical role in cancer development and progression. However, the heterogeneity of TAM presents a major challenge to identify clinically relevant markers for protumor TAM. Here, we report that expression of adipocyte/macrophage fatty acid–binding protein (A-FABP) in TAM promotes breast cancer progression. Although upregulation of A-FABP was inversely associated with breast cancer survival, deficiency of A-FABP significantly reduced mammary tumor growth and metastasis. Furthermore, the protumor effect of A-FABP was mediated by TAM, in particular, in a subset of TAM with a CD11b&lt;sup&gt;+&lt;/sup&gt;F4/80&lt;sup&gt;+&lt;/sup&gt;MHCII&lt;sup&gt;−&lt;/sup&gt;Ly6C&lt;sup&gt;−&lt;/sup&gt; phenotype. A-FABP expression in TAM facilitated protumor IL6/STAT3 signaling through regulation of the NFκB/&lt;i&gt;miR-29b&lt;/i&gt; pathway. Collectively, our results suggest A-FABP as a new functional marker for protumor TAM.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Significance:&lt;/b&gt; These findings identify A-FABP as a functional marker for protumor macrophages, thus offering a new target for tumor immunotherapy. &lt;i&gt;Cancer Res; 78(9); 2343–55. ©2018 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Hypoxia-induced autophagy (2012)

A major challenge in formulating an effective immunotherapy is to overcome the mechanisms of tumor escape from immunosurveillance. We showed that hypoxia-induced autophagy impairs cytotoxic T-lymphocyte (CTL)-mediated tumor cell lysis by regulating phospho-STAT3 in target cells. Autophagy inhibition in hypoxic cells decreases phospho-STAT3 and restores CTL-mediated tumor cell killing by a mechanism involving the ubiquitin proteasome system and SQSTM1/p62. Simultaneously boosting the CTL-response, using a TRP-peptide vaccination strategy, and targeting autophagy in hypoxic tumors, improves the efficacy of cancer vaccines and promotes tumor regression in vivo. Overall, in addition to its immunosuppressive effect, the hypoxic microenvironment also contributes to immunoresistance and can be detrimental to antitumor effector cell functions.
New thiophosphorimides (1972)

The new thiophosphorimides P4(NMe)6Sn, with n= 1–3, have structures related to those of the series of oxides P4O7, P4O8, and P4O9; scrambling of the peripheral sulphur atoms gave equilibrated mixtures in which the inner P4(NMe)6 core is retained.
Improve Oil Production From Tar-Impacted Reservoirs Using In-Situ Steam Generation and Ionic Liquids (2021)

Abstract One of the typical production challenges is occurrence of impermeable layers of highly viscous asphaltenic oil (known as tarmat) at oil/water contact within a reservoir. Tar forms a physical barrier that isolates producing zones from aquifer or water injectors. As a result of tar occurrence, is a rapid pressure decrease that can be observed in such reservoirs, increasing number of dead wells, and declining productivity. Another indirect consequence of Tar presence is poor sweep efficiency that leads to water cut increase by a drastic magnitude. An innovative approach was developed to establish better sweep efficiency, transmissibility and pressure maintenance of Tar impacted-areas using thermochemical treatment. The treatment consists of injecting exothermic reaction-components that react downhole and generate in-situ pressure and heat. The in-situ reaction products provide heat and gas-drive energy to mobilize tar, improve sweep efficiency and maintain flooding for better pressure maintenance. Typically, downhole heat generation through chemical reaction releases substantial heat which could be employed in various thermal stimulation operations. Nano/ionic liquids, high pH solutions, solvents and nano metals were combined with the exothermic reaction to improve tar mobilization. Based on lab testing, the new technology showed more recovery than conventional steam flooding. Permeable channels were created in a tar layer with sandback samples, which enhanced transmissibility, pressure support and sweep efficiency. The effect of thermochemical treatment and ionic liquid on bitumen texture will be described. Impact of In-situ generated heat on injectivity will also be presented. The novel method will enable commercial production from tar-impacted reservoirs, and avoid costly steam flooding systems. The developed novel treatment relates to in-situ steam generation to maximize heat delivery efficiency of steam into the reservoir and to minimize heat losses due to under and/or over burdens. The generated in-situ steam and gas can be applied to recover deep oil reservoirs, which cannot be recovered with traditional steam, miscible gas, nor polymer injection methods.
Síntesis de la zeolita ITQ-51, procedimiento de obtención y uso (2014)

La presente invención se refiere a un material&#13;\ncristalino que se ha denominado ITQ-51 y que tiene&#13;\nuna composición molar en su estado calcinado y&#13;\nanhidro que viene dado por la ecuación:&#13;\ndonde:&#13;\n- M es un elemento, o mezcla de elementos,&#13;\ndiferentes a Si, Al y P.&#13;\n- El valor de x está comprendido entre 0 y 1.5,&#13;\npreferentemente entre 0 y 0.8.&#13;\n- El valor de y está comprendido entre 0.3 y 1.6,&#13;\npreferentemente entre 0.6 y 1.3.&#13;\n- El valor de z está comprendido entre 0 y 1.5,&#13;\npreferentemente entre 0 y 0.8.
A 1-V high-speed MTCMOS circuit scheme for power-down application circuits (1997)

This paper proposes a new multithreshold-voltage CMOS circuit (MTCMOS) concept aimed at achieving high-speed, ultralow-power large-scale integrators (LSI's) for battery-driven portable equipment. The "balloon" circuit scheme based on this concept preserves data during the power-down period in which the power supply to the circuit is cut off in order to reduce the standby power. Low-power, high-speed performance is achieved by the small preserving circuit which can be separated from the critical path of the logic circuit. This preserving circuit is not only three times faster than a conventional MTCMOS one, but it consumes half the power and takes up half the area. Using this scheme for an LSI chip, 20-MHz operation at 1.0 V and only a few nA standby current was achieved with 0.5-/spl mu/m CMOS technology. Moreover, this scheme is effective for high speed and low-power operation in quarter-micrometer and finer devices.
[A new strategy of neonatal screening for cystic fibrosis. The association of immunoreactive trypsin and molecular biology in dried blood]. (1990)

Cystic fibrosis (CF) screening by means of immunoreactive trypsin (IRT) lacks specificity: only 1 out of 12 hypertrypsinemic neonates has cystic fibrosis. We propose here to analyse the KM.19 polymorphic site in the dried blood spots as an additional test in hypertrypsinemic neonates. A blind retrospective study of 114 hypertrypsinemic samples has been performed after polymerase chain reaction. Twenty-seven of 37 CF (74%) were homozygous for allele 2 (2-2) and could have been diagnosed on the 15th day of life. Fifty-five percent of the infants tested were homozygous for allele 1 (1-1), a very rare feature in CF, conferring them a probability of being normal of 99.8%. At the moment, this test could be of great help in the CF screening, even better than the search for the delta F508 mutation for which 45.9% of CF patients are homozygous.