gebhart/patrepeval huggingface dataset:
7,8-Dihydropteroyl oligo-γ-L-glutamates. Synthesis and kinetic studies with purified dihydrofolate reductase from mammalian sources (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT7,8-Dihydropteroyl oligo-γ-L-glutamates. Synthesis and kinetic studies with purified dihydrofolate reductase from mammalian sourcesJames K. Coward, K. N. Parameswaran, Arlene R. Cashmore, and Joseph R. BertinoCite this: Biochemistry 1974, 13, 19, 3899–3903Publication Date (Print):September 1, 1974Publication History Published online1 May 2002Published inissue 1 September 1974https://pubs.acs.org/doi/10.1021/bi00716a013https://doi.org/10.1021/bi00716a013research-articleACS PublicationsRequest reuse permissionsArticle Views73Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Static Power Allocation in Two-Hop MIMO Amplify-and-Forward Relay Systems (2009)

In this paper, we propose a static power allocation algorithm for a two-hop multi-input-multi-output (MIMO) amplify-and-forward (AF) relay system in which the interim channel state information over the first and the second hops is unavailable. Based on the path losses over the first and the second hops, this algorithm performs static power allocation between the source and relay nodes to maximize the equivalent received SNR of the system. We further investigate the optimal location of the relay node when the conventional fixed and the proposed optimal static power allocation schemes are applied. Our comparison between direct transmission and relay-based two-hop transmission indicates that whether the latter outperforms the former depends on a tradeoff between the received SNR gain and the multiplexing loss in the relay-based two-hop transmission scheme.
Resolution Limits for Resonant Mems Sensors Based on Discrete Relay Feedback Techniques (2007)

This paper is devoted to the analysis of resonant MEMS sensors based on discrete relay feedback techniques. One drawback of such techniques is that some synchronization usually occurs between the discrete part and the continuous part of the system: this results in sensor responses that are very similar to the curves known as devil's staircases, i.e. the frequency does not vary smoothly with the sensor's input. The main contribution of this paper is a theoretical calculation of the resolution of such systems. The resolutions of two existing resonant MEMS architectures are then calculated and these results are discussed.
Wide Color Gamut Deep-Blue OLED Architecture for Display Application (2018)

Organic light emitting diodes (OLEDs) are considered to be among the best flat panel display technologies owing to their wide viewing angle, wide color gamut, high speed response, high resolution, and simple structure. In order to enhance the realism, wide color gamut is of vital importance to all the display devices. Here, we demonstrate a wide color gamut, deep-blue OLED for the next generation high quality full-panel displays based on the lateral introduction of the cyano group on a local excited (LE) chromophoric axis, which significantly affects the nature of the excited state and leads to the optimal hybridization local and charge transfer states (HCLT). Most notably, OLED based on the HLCT molecule (C4) showed more than two-fold increment in the external quantum efficiency (EQE) and uncompromised color purity as compared to a molecule (C1), which lacks cyano group and possesses LE state. The engineered molecular design features cross-conjugated localized and charge-transfer chromophores which result in a hybridized local charge transfer (HLCT) excited state. OLED using this material presented greater than 6.5% external quantum efficiency with excellent color saturation (CIEy ~0.058) and small full-width at half maximum (46nm). Additionally, the resultant deep blue emission achieved 99, 101, 101, 100, and 96 % color saturation compared with the sRGB, NTSC, Adobe RGB, HDTV ITU-R BT.709-5, and Rec. 2020 standards, respectively.
Wavefront Shaping for Wireless Communications in Complex Media: From Time Reversal to Reconfigurable Intelligent Surfaces (2022)

Reconfigurable intelligent surfaces (RISs) are gaining huge momentum in the field of wireless communications due to the paradigm shift that they bring. Indeed, they allow making any environment electromagnetically smart and dynamically reconfigurable for more efficient and greener wireless communications. As physicists, we proposed to use electronically tunable metasurfaces to shape the electromagnetic waves carrying our wireless communications in reflection almost ten years ago, inspired by some works that we and colleagues did in the field of wave control in complex media. In this article, we review the seminal works that led us to propose this concept, starting from the original one that is time reversal. Then, we propose a physicist’s point of view of RISs using a comparison with phase conjugation. Finally, we highlight what we think are their limitations, relying on both our knowledge of wave control and our study of them over a decade.
DC and RF breakdown voltage characteristics of SiGe HBTs for WiFi PA applications (2016)

Breakdown voltage and RF characteristics relevant for RF power amplifiers (PA) are presented in this paper. Typically, DC collector-to-emitter breakdown voltage with base open (BV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CEO</sub> ) or DC collector-to-base breakdown with emitter open (BV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CBO</sub> ) has been presented as the metric for voltage limit of PA devices. In practical PA circuits, the RF envelope voltage can swing well beyond BV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CEO</sub> without causing a failure. An analysis of output power swing limitations and DC breakdown is presented with attention to biasing and temperature.
Differential topology rectifier design for ambient wireless energy harvesting (2016)

In this paper, two types of differential topology rectifier are studied and designed for RF energy harvesting at GSM1800 band 1.83GHz. The proposed differential serial rectifier and differential doubler rectifier are with odd harmonics suppression characteristics. Radial stubs are utilized to filter the output harmonics, which makes the rectifier more compact. The rectifiers with Schottky diodes (SMS7630) are fabricated on Teflon substrate. Measured maximum efficiencies of two rectifiers are 49% @ 0dBm and 53% @ 2dBm, respectively. The results show that the rectifiers are efficient, power sensitive and compact. An application scenario of proposed rectifier are demonstrated. The proposed rectifiers can be used in many RF energy harvesting system, including RFID applications.
Low-loss, low return-loss coupling between SMF and single-mode, hollow-core fibers using connectors (2014)

We demonstrate the first low-loss, low-return-loss FC/PC connector for a single-mode, hollow-core fiber. Connector loss of 0.3dB and return loss of −31.3dB was measured, and a 200m HCF jumper with connectors on both ends was fabricated.
Data from <i>PTEN</i> Loss Contributes to Erlotinib Resistance in EGFR-Mutant Lung Cancer by Activation of Akt and EGFR (2023)

&lt;div&gt;Abstract&lt;p&gt;Clinical resistance to epidermal growth factor receptor (EGFR) inhibition in lung cancer has been linked to the emergence of the EGFR T790M resistance mutation or amplification of &lt;i&gt;MET&lt;/i&gt;. Additional mechanisms contributing to EGFR inhibitor resistance remain elusive. By applying combined analyses of gene expression, copy number, and biochemical analyses of EGFR inhibitor responsiveness, we identified homozygous loss of &lt;i&gt;PTEN&lt;/i&gt; to segregate EGFR-dependent and EGFR-independent cells. We show that in EGFR-dependent cells, &lt;i&gt;PTEN&lt;/i&gt; loss partially uncouples mutant EGFR from downstream signaling and activates EGFR, thereby contributing to erlotinib resistance. The clinical relevance of our findings is supported by the observation of &lt;i&gt;PTEN&lt;/i&gt; loss in 1 out of 24 primary EGFR-mutant non–small cell lung cancer (NSCLC) tumors. These results suggest a novel resistance mechanism in &lt;i&gt;EGFR&lt;/i&gt;-mutant NSCLC involving &lt;i&gt;PTEN&lt;/i&gt; loss. [Cancer Res 2009;69(8):3256–61]&lt;/p&gt;&lt;/div&gt;
An efficient gene excision system in maize (2020)

ABSTRACT Use of the morphogenic genes Baby Boom ( Bbm ) and Wuschel2 ( Wus2 ), along with new ternary constructs, has increased the genotype range and the type of explants that can be used for maize transformation. In addition, altering the ectopic expression pattern for Bbm/Wus2 has resulted in rapid maize transformation methods that are faster and applicable to a broader range of inbreds. However, expression of Bbm/Wus2 can compromise the quality of regenerated plants, leading to sterility. We reasoned excising morphogenic genes after transformation but before regeneration would increase production of fertile T0 plants. We developed a method that uses an inducible site-specific recombinase ( Cre ) to excise morphogenic genes. The use of developmentally regulated promoters, such as Ole, Glb1, End2 and Ltp2 , to drive Cre enabled excision of morphogenic genes in early embryo development and produced excised events at a rate of 25%-100%. A different strategy utilizing an excision-activated selectable marker produced excised events at a rate of 53.3%-68.4%; however, the transformation frequency was lower (12.9%-49.9%). The use of inducible heat shock promoters (e.g. Hsp17.7, Hsp26 ) to express Cre, along with improvements in tissue culture conditions and construct design, resulted in high frequencies of T0 transformation (29%-69%), excision (50%-97%), usable quality events (3.6%-14%), and few escapes (non-transgenic; 14%-17%) in three elite maize inbreds. Transgenic events produced by this method are free of morphogenic and marker genes.
Estrogenic properties of prenylated isoflavones in U2OS human osteosarcoma cells: structure-activity relationships (2010)

In a continuation study aiming to discover novel phytoestrogens, we recently reported the isolation and characterization of novel and known isoflavonoids from Erythrina poeppigiana (Walp.) O.F. Cook. (Fabaceae), among which eight appear to be structurally related to genistein with isoprenyl and/or 7-methoxy substitution. In addition, significant binding affinities for the two isotypes of the estrogen receptor ERα and ERβ were demonstrated [1]. These isoflavones derivatives have been investigated for their estrogenic properties in receptor subtype specific reporter gene assay, with a particular focus on their estrogen receptor alpha and beta (ERα and ERβ) selectivity, and their structure-activity relationships using a bone-derived human osteosarcoma cell line (U2OS cells) stably expressing ERα or transiently expressing ERβ. According to our results, an isoprenyl substitution at position 3? together with a 7-methoxy substitution on the genistein skeleton is associated with a statiscally significant activation of the ERα- and ERβ-dependent reporter gene expression in U2OS cells starting from 0.1 nM; while for genistein itself a statistically significant activation was observable at 1 nM. On the other hand, a double prenylation at position 8 and 3? is associated with an almost complete loss of function on the reporter gene activation in U2OS-ERα, but in ERβ expressing system, the effectiveness remains on a statistically significant level, demonstrating an „exclusive ERβ-selectivity“ in U2OS human osteosarcoma cells.
Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer (2020)

Replication stress and DDR deficiency are independent of each other, creating opportunities for therapy in DDR-proficient PC and after platinum therapy.
A subsequence-histogram method for generic vocabulary recognition over deletion channels (2009)

We consider the problem of recognizing a vocabulary-a collection of words (sequences) over a finite alphabet-from a potential subsequence of one of its words. We assume the given subsequence is received through a deletion channel as a result of transmission of a random word from one of the two generic underlying vocabularies. An exact maximum a posterior (MAP) solution for this problem counts the number of ways a given subsequence can be derived from particular subsets of candidate vocabularies, requiring exponential time or space.
Activation of cytotoxic T-cell receptor T lymphocytes in response to specific stimulation in myelodysplastic syndromes (2008)

These results, combined with our previous findings concerning natural killer cells, suggest that there are immune surveillance defects in myelodysplastic syndromes, which may contribute to the pathogenesis of these syndromes.
Salvage Prostate Cryoablation: Initial Results From the Cryo On-Line Data Registry (2008)

Biochemical and local control rates support the use of salvage cryoablation for localized recurrence following failed radiation therapy. Efforts to continue to minimize these complications and to improve disease control in patients with persistent cancer following definitive radiotherapy should continue.
Abnormal Output Characteristics of p-Type Low Temperature Polycrystalline Silicon Thin Film Transistor Fabricated on Polyimide Substrate (2015)

We report on an abnormal output characteristics in p-type low temperature polycrystalline silicon thin-film transistors fabricated on polyimide (PI); negative differential conductance behavior is often observed in saturation region of drain current from large width devices. To understand such abnormal output characteristics, device dimension dependence was studied in a systematic way. As a result, we found that enhanced self-heating is mainly responsible originating from the poor thermal conductivity of PI substrate. A related degradation model is also proposed.
Radiation Chemical Reaction and Submicron Pattern Fabrication on 10,12-Pentacosadiynoic Acid LB Films Using X-Ray Irradiation (1989)

X-ray induced polymerization of 10,12-pentacosadiynoic acid (PDA) Langmuir-Blodgett (LB) films has been studied in relation to the molecular density or arrangement for use in X-ray resists. Two typical PDA LB films of different molecular densities were polymerized to form different polymer LB films by X-ray irradiation. The low-density PDA LB films (A type) were more sensitive than the high-density PDA LB films (B type) when X-ray was irradiated in helium atmosphere and the polymerization was caused topochemically on A-type film but not on B-type film. Decomposition of polymerized films was observed by excessive irradiation of X-ray for A-type film, but not for B-type film. Using both types of PDA LB films, 0.4 µm patterns could be fabricated by X-ray exposure.
Naringenin attenuates the release of pro-inflammatory mediators from lipopolysaccharide-stimulated BV2 microglia by inactivating nuclear factor-κB and inhibiting mitogen-activated protein kinases (2012)

Naringenin, one of the most abundant flavonoids in citrus fruits and grapefruits, has been reported to exhibit anti-inflammatory and antitumor activities. However, the cellular and molecular mechanisms underlying the naringenin anti-inflammatory activity are poorly understood. In this study, we conducted an investigation of the inhibitory effects of naringenin on the production of lipopolysaccharide (LPS)-induced pro-inflammatory mediators in BV2 microglial cells. We found that pre-treatment with naringenin prior to treatment with LPS significantly inhibited excessive production of nitric oxide (NO) and prostaglandin E2 (PGE2) in a dose-dependent manner. The inhibition was associated with downregulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression. Naringenin also attenuated the production of pro-inflammatory cytokines and chemokines, including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein-1 (MCP-1) by suppressing expression of mRNAs for these proteins. In addition, the molecular mechanism underlying naringenin-mediated attenuation in BV2 cells has a close relationship to suppressing translocation of the nuclear factor-κB (NF-κB) p65 subunit into the nucleus and the phosphorylation of Akt and mitogen-activated protein kinases (MAPKs). These findings suggest that naringenin may provide neuroprotection through suppression of pro-inflammatory pathways in activated BV2 microglial cells.
Opportunities for employing silicon carbide in high power photo-switches (2004)

High electric field geometries for high power, photoconductive switches made possible by employing subbandgap energy photons and inter-bandgap dopants / defects are being investigated for compact pulse power systems. The high field, long absorption depth package reduces the required linear mode, optical closure energy and also reduces the conduction current density through the active material and at the contacts. This paper describes the opportunities for employing semi-insulating SiC wafer in the University of Missouri-Columbia, high electric field configuration. The parameters of semi-insulating SiC materials and methods of fabricating such materials into a high power photo-switch are discussed. In addition, transient modeling of the transverse injection of optical closure energy is discussed.
Time-Gated Fourier Domain Optical Coherence Tomography (2007)

A novel OCT system is presented that combines FDOCT with ultra-fast time-gating. By processing backscattered light in the optical domain, the user can select a limited field of view for improved contrast and acquisition speed.
Cytogenetic Profile Predicts Prognosis of Patients With Clear Cell Renal Cell Carcinoma (2009)

This cytogenetic study serves as a proof of principal that genetic information, such as loss of chromosome 9, can be obtained from widely available technology, and can provide additional prognostic information to standard clinicopathologic variables.
Reliable RF B/E-Field Probes for Time-Domain Monitoring of EM Exposure During Medical Device Testing (2017)

This paper presents electric and magnetic probes to measure radio frequency (RF) electric and magnetic fields for measuring the time-varying RF fields used in magnetic resonance imaging (MRI). A small single loop (2 cm) and short dipole antenna (2 cm) were developed to monitor the near field magnetic and electric exposure during the medical device testing. Theoretical analysis for each designed probe was performed to convert the real time receive signals to the exposed electric and magnetic field. Probes in this paper were tuned and matched at center frequency of 127.6 MHz for 3T MRI scanners to improve the accuracy and sensitivity. Different cables were designed to reduce the E-field pick up and achieving the most accurate measurement setup. Probes were fabricated on a single sided printed circuit board, FR4 of thickness 1.57 mm and a copper thickness of 35 μm. The measured S-parameters of the magnetic and electric field probes show less than -44 and -45 dB return loss at 127.6-MHz center frequency of the RF Birdcage.
Time‐dependent density functional calculations of the Q‐like bands of phenylene‐linked free‐base and zinc porphyrin dimers (2001)

Abstract Time‐dependent density functional theory (TDDFT) calculations have been performed on the excitation energies and oscillator strengths of the Q‐like bands of three structural isomers of phenylene‐linked free‐base (FBP) and zinc (ZnP) porphyrin dimers. The TDDFT calculated results on the low‐lying excited states of the reference monomers, FBP and ZnP, are in excellent agreement with previously calculated and experimental results. It is found that the 1,3‐ and 1,4‐phenylene‐linked dimers have monomerlike Q bands that are slightly red‐shifted compared to the monomers and new Q′ bands comprised of the cross‐linked excitations from the FBP (ZnP) ring to the ZnP (FBP) ring at considerably lower energies than the monomer Q bands. For the 1,2‐phenylene‐linked dimer, the direct π–π interaction between porphyrin rings caused by the van der Waals repulsion between them provides strong mixing of the Q′ bands with the Q bands, which causes its minimum excitation energy to be red‐shifted by 0.05 eV compared to the other isomers. The oscillator strengths of the Q′ bands are also unexpectedly found to be as strong as those of the Q bands in the dimers. © 2001 John Wiley &amp; Sons, Inc. Int J Quantum Chem 84: 338–347, 2001
Imidazole Compounds for Protecting Choroidal Endothelial Cells from Complement Injury (2018)

Age-related macular degeneration (AMD) is a common, blinding disease associated with increased complement system activity. Eyes with AMD show elevated accumulation of the membrane attack complex (MAC) in the choriocapillaris and degeneration of macular choriocapillaris endothelial cells (ECs). Thus, one could reasonably conclude that the endothelial cell death that occurs in AMD is due to injury by the MAC. We therefore sought to identify strategies for protecting ECs against MAC lysis. RF/6A endothelial cells were pre-incubated with a library of FDA-approved small molecules, followed by incubation with complement intact human serum quantification of cell death. Two closely related molecules identified in the screen, econazole nitrate and miconazole nitrate, were followed in validation and mechanistic studies. Both compounds reduced lysis of choroidal ECs treated with complement-intact serum, across a range of doses from 1 to 100 µM. Cell rescue was confirmed in mouse primary choroidal ECs. Both exosome release and cell surface roughness (assessed using a Holomonitor system) were reduced by drug pretreatment in RF/6A cells, whereas endosome formation increased with both drugs, consistent with imidazole-mediated alterations of cell surface dynamics. The results in the current study provide further proof of principle that small molecules can protect choroidal ECs from MAC-induced cell death and suggest that FDA approved compounds may be beneficial in reducing vascular loss and progression of AMD.