gebhart/patrepeval huggingface dataset:
P2X3 Receptor Antagonism Reduces Peripheral Chemoreceptor Reflex Hypersensitivity and Blood Pressure in the Spontaneously Hypertensive Rat (2015)

Arterial hypertension is associated with increased peripheral chemoreceptor reflex sensitivity. We have shown that bilateral carotid body (CBR) resection in spontaneously hypertensive (SH) rats reduces arterial pressure (AP). Since ATP is a major participant in CB transduction signalling, and P2X3 receptors are associated with visceral afferent sensitisation, we hypothesized that P2X3 antagonism would reduce chemoreflex hypersensitivity and lower AP in SH rats. SH and Wistar rats were implanted with telemeters to record AP. Doses of a P2X3 receptor antagonist (AF‐219) were administered as an i.v. bolus: 0.5 (n=4), 1 (n=4), 2 (n=5), 4 (n=5) and 8 mg/kg (n=4), and changes in both basal AP and chemoreflex sensitivity assessed. The chemoreflex was stimulated with sodium cyanide (NaCN; 120 μg/kg i.v.). At all doses, AF‐219 diminished NaCN evoked AP responses (P=0.084) in SH rats. In SH rats, basal AP was reduced by AF‐219 (P&lt;0.05): ‐8±3 mmHg, 0.5mg/kg; ‐16±1 mmHg, 1mg/kg: ‐18±3 mmHg, 2mg/kg; ‐13±1 mmHg, 4mg/kg; ‐13±2 mmHg, 8mg/kg. In normotensive Wistars, AF‐219 did not reduce AP vs. baseline (‐4±2 mmHg, 1 mg/kg; P&gt;0.05). Injections of vehicle had no effect in either rat strain (n=4). In SH rats, CBR blunted the 1 mg/kg AF‐219 induced fall in AP vs. non‐CBR rats. However, the fall versus baseline in AP in SH‐CBR rats remained significant (‐8±1 mmHg,P&lt;0.01). P2X3 receptor antagonism depresses chemoreflex hypersensitivity and lowers AP in SH rats to a level observed after selective CBR. P2X3 receptor antagonism may provide a novel way to attenuate CB tonicity in SH rats and as such become a novel target for controlling hypertension. Supported by: British Heart Foundation and the NIH
Phase-Resolved Detection of the Spin Hall Angle by Optical Ferromagnetic Resonance in Perpendicularly Magnetized Thin Films (2017)

The conversion of charge current to spin current by the spin Hall effect is of considerable current interest from both fundamental and technological perspectives. Measurement of the spin Hall angle, especially for atomically thin systems with large magnetic anisotropies, is not straightforward. Here we demonstrate a hybrid phase-resolved optical-electrical ferromagnetic resonance method that we show can robustly determine the spin Hall angle in heavy-metal/ferromagnet bilayer systems with large perpendicular magnetic anisotropy. We present an analytical model of the ferromagnetic resonance spectrum in the presence of the spin Hall effect, in which the spin Hall angle can be directly determined from the changes in the amplitude response as a function of the spin current that is generated from a dc charge current passing through the heavy-metal layer. Increased sensitivity to the spin current is achieved by operation under conditions for which the magnetic potential is shallowest at the ``Smit point.'' Study of the phase response reveals that the spin Hall angle can be reliably extracted from a simplified measurement that does not require scanning over time or magnetic field but rather only on the dc current. The method is applied to the Pt-Co/Ni/Co system whose spin Hall angle was to date characterized only indirectly and that is especially relevant for spin-orbit torque devices.
Donor safety in living donor liver transplantation: The Korean organ transplantation registry study (2017)

Major concerns about donor safety cause controversy and limit the use of living donor liver transplantation to overcome organ shortages. The Korean Organ Transplantation Registry established a nationwide organ transplantation registration system in 2014. We reviewed the prospectively collected data of all 832 living liver donors who underwent procedures between April 2014 and December 2015. We allocated the donors to a left lobe group (n = 59) and a right lobe group (n = 773) and analyzed the relations between graft types and remaining liver volumes and complications (graded using the Clavien 5-tier grading system). The median follow-up was 19 months (range, 10-31 months). During the study period, 553 men and 279 women donated livers, and there were no deaths after living liver donation. The overall, biliary, and major complication (grade ≥ III) rates were 9.3%, 1.7%, and 1.9%, respectively. The graft types and remaining liver volume were associated with significantly different overall, biliary, and major complication rates. Of the 16 patients with major complications, 9 (56.3%) involved biliary complications (2 biliary strictures [12.5%] and 7 bile leakages [43.8%]). Among the 832 donors, the mean aspartate transaminase, alanine aminotransferase, and total bilirubin levels were 23.9 ± 8.1 IU/L, 20.9 ± 11.3 IU/L, and 0.8 ± 0.4 mg/dL, respectively, 6 months after liver donation. In conclusion, biliary complications were the most common types of major morbidity in living liver donors. Donor hepatectomy can be performed successfully with minimal and easily controlled complications. Our study shows that prospective, nationwide cohort data provide an important means of investigating the safety in living liver donation. Liver Transplantation 23 999-1006 2017 AASLD.
Chromoendoscopy Detects More Adenomas than Colonoscopy Using Intensive Inspection without Dye Spraying (2008)

Conventional colonoscopy misses some neoplastic lesions. We compared the sensitivity of chromoendoscopy and colonoscopy with intensive inspection for detecting adenomatous polyps missed by conventional colonoscopy. Fifty subjects with a history of colorectal cancer or adenomas underwent tandem colonoscopies at one of five centers of the Great Lakes New England Clinical Epidemiology and Validation Center of the Early Detection Research Network. The first exam was a conventional colonoscopy with removal of all visualized polyps. The second exam was randomly assigned as either pan-colonic indigocarmine chromoendoscopy or standard colonoscopy with intensive inspection lasting >20 minutes. Size, histology, and numbers of polyps detected on each exam were recorded. Twenty-seven subjects were randomized to a second exam with chromoendoscopy and 23 underwent intensive inspection. Forty adenomas were identified on the first standard colonoscopies. The second colonoscopies detected 24 additional adenomas: 19 were found using chromoendoscopy and 5 were found using intensive inspection. Chromoendoscopy found additional adenomas in more subjects than did intensive inspection (44% versus 17%) and identified significantly more missed adenomas per subject (0.7 versus 0.2, P < 0.01). Adenomas detected with chromoendoscopy were significantly smaller (mean size 2.66 +/- 0.97 mm) and were more often right-sided. Chromoendoscopy was associated with more normal tissue biopsies and longer procedure times than intensive inspection. After controlling for procedure time, chromoendoscopy detected more adenomas and hyperplastic polyps compared with colonoscopy using intensive inspection alone. Chromoendoscopy detected more polyps missed by standard colonoscopy than did intensive inspection. The clinical significance of these small missed lesions warrants further study.
Refractive index change measurement by quantitative microscopy phase imaging for femtosecond laser written structures (2020)

Quantitative phase imaging has been widely exploited and developed during the last decade. This technique is efficient, allowing for quantitative and qualitative spatially resolved measurements of the refractive index profiles. However, there are some measurement limitations for thick samples when exceeding the depth of field-of-view of the imaging system. In this paper, we present an approach based on the complete Rayleigh–Sommerfeld diffraction theory, which allows quantitative retrieve of the refractive index change from the measured optical path difference, especially in the case of thick samples. This approach is validated by a comparison with experimental measurements of refractive index changes of distinct series of cylindrically shaped volume modifications inscribed by femtosecond laser irradiation in silica glass. The results presented hereby, enable quantitative measurement of refractive index change for thick embedded 3D structures.
ChemInform Abstract: Synthesis and Structural Characterization of Zirconium Complexes Containing Aminodiolate Ligands and Their Use as Lewis Acid Catalysts. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
High Efficiency Resonant DC/DC Converter Utilizing a Resistance Compression Network (2013)

This paper presents a new topology for a high-efficiency dc/dc resonant power converter that utilizes a resistance compression network (RCN) to provide simultaneous zero-voltage switching and near-zero-current switching across a wide range of input voltage, output voltage, and power levels. The RCN maintains desired current waveforms over a wide range of voltage operating conditions. The use of ON/OFF control in conjunction with narrowband frequency control enables high efficiency to be maintained across a wide range of power levels. The converter implementation provides galvanic isolation and enables large (greater than 1:10) voltage conversion ratios, making the system suitable for large step-up conversion in applications such as distributed photovoltaic converters. Experimental results from a 200-W prototype operating at 500 kHz show that over 95% efficiency is maintained across an input voltage range of 25-40 V with an output voltage of 400 V. It is also shown that the converter operates very efficiently over a wide output voltage range of 250-400 V, and a wide output power range of 20-200 W. These experimental results demonstrate the effectiveness of the proposed design.
Designing Compound Subsets:  Comparison of Random and Rational Approaches Using Statistical Simulation (2007)

Compound subsets, which may be screened where it is not feasible or desirable to screen all available compounds, may be designed using rational or random selection. Literature on the relative performance of random versus rational selection reports conflicting observations, possibly because some random subsets might be more representative than others and perform better than subsets designed by rational means, or vice versa. In order to address this likelihood, we simulated a large number of rationally designed subsets for evaluation against an equally large number of randomly generated subsets. We found that our rationally designed subsets give higher mean hit rates compared to those of the random ones. We also compared subsets comprising random plates with subsets of random compounds and found that, while the mean hit rate of both is the same, the former demonstrates more variation in the hit rate. The choice of compound file, rational subset method, and ratio of the subset size to the compound file size are key factors in the relative performance of random and rational selection, and statistical simulation is a viable way to identify the selection approach appropriate for a subset.
Ethanol Suppresses LPS‐induced Toll‐like Receptor 4 Clustering, Reorganization of the Actin Cytoskeleton, and Associated TNF‐α Production (2006)

These data confirm our previous observations, suggest a novel mechanism of EtOH action that involves interference with receptor clustering, and indicate a potential role of actin filaments in the formation of receptor patches, subsequent activation of macrophages by LPS, and production of TNF-alpha.
BPR (2012)

Numerous studies have shown the advantages of hardware and software co-design using FPGAs. However, increasingly lengthy place-and-route times represent a barrier to the broader adoption of this technology by significantly reducing designer productivity and turns-per-day, especially compared to more traditional design environments offered by competitive technologies such as GPUs. In this paper, we address this challenge by introducing a new approach to FPGA application design that significantly reduces compile times by exploiting the functional reuse common throughout modern FPGA applications, e.g. as shared code libraries and unchanged modules between compiles. To evaluate this approach, we introduce Block Place and Route (BPR), an FPGA CAD approach that modifies traditional placement and routing to operate at a higher-level of abstraction by pre-computing the internal placement and routing of reused cores. By extending traditional place-and-route algorithms such as simulated-annealing placement and negotiated-congestion routing to abstract away the detailed implementation of reused cores, we show that BPR is capable of orders-of-magnitude speedup in place-and-route over commercial tools with acceptably low overhead for a variety of applications.
Antiretroviral Drugs Alter the Content of Extracellular Vesicles from HIV-1-Infected Cells (2018)

To date, the most effective treatment of HIV-1 is a combination antiretroviral therapy (cART), which reduces viral replication and reverses pathology. We investigated the effect of cART (RT and protease inhibitors) on the content of extracellular vesicles (EVs) released from HIV-1-infected cells. We have previously shown that EVs contain non-coding HIV-1 RNA, which can elicit responses in recipient cells. In this manuscript, we show that TAR RNA levels demonstrate little change with the addition of cART treatment in cell lines, primary macrophages, and patient biofluids. We determined possible mechanisms involved in the selective packaging of HIV-1 RNA into EVs, specifically an increase in EV-associated hnRNP A2/B1. More recent experiments have shown that several other FDA-approved drugs have the ability to alter the content of exosomes released from HIV-1-infected cells. These findings on cART-altered EV content can also be applied to general viral inhibitors (interferons) which are used to treat other chronic infections. Additionally, we describe unique mechanisms of ESCRT pathway manipulation by antivirals, specifically the targeting of VPS4. Collectively, these data imply that, despite antiretroviral therapy, EVs containing viral products are continually released and may cause neurocognitive and immunological dysfunction.
ChemInform Abstract: ANTIALLERGY AGENTS. 1. 1,6‐DIHYDRO‐6‐OXO‐2‐PHENYLPYRIMIDINE‐5‐CARBOXYLIC ACIDS AND ESTERS (1979)

Abstract Auf den im Formelschema" angedeuteten Wegen werden einige Py‐rimidincarbonsäuren‐ und ‐ester dargestellt und auf antiallergische Wirkung im PCA‐Versuch an Ratten geprüft.
Nanometer design (2002)

Every year, the design and EDA communities are besieged by dire warnings about the impending doom of "design as we know it." Every year, another unpleasant physical effect from the evil depths of deep submicron physics surfaces, compromising our designs in new and vile ways. Every year, the same story: more nanometer woes. Rather than endorse a new winner in this year's race for the next worst thing from the nanometer arena, this panel gathers a set of world-class technology experts to debate what effects are hiding just around the next corner, waiting to pounce on the unwary tool or chip designer. Which among these is really the most important, when will it happen, and why.
Long-Term and Tight Control of Gene Expression in Mouse Skeletal Muscle by a New Hybrid Human Transcription Factor (2002)

Diseases requiring frequent and lifelong injections of recombinant proteins would be more efficaciously treated by intramuscular delivery of genes encoding secretable proteins. However, the success of this approach largely depends on our capability to temporally regulate transcription of delivered genes. Therefore, we sought to generate a humanized transcription factor to regulate transgene expression in muscle. A novel 4-hydroxytamoxifen (4-OHT)-dependent transcriptional regulator (called HEA-3) was constructed by fusing in-frame the DNA binding domain of the human hepatocyte nuclear factor-1α (HNF1α), which is not expressed in muscle cells, a G(521)R mutant of the ligand binding domain of human estrogen receptor-α (ERα), and the activation domain derived from human nuclear factor-κB p65 subunit (NF-κB p65). We demonstrate that an artificial promoter containing multimeric HNF1α binding sites is silent in muscles and in cell lines that lack endogenous HNF1α. HEA-3 stimulated transcription from this target promoter in a stringent 4-OHT-dependent manner. The dynamic range of transgene regulation was high, because of the low basal activity and high inducibility of the system. Ex vivo, HEA-3 increased expression of the transfected reporter gene by more than 1000-fold in a ligand-dependent manner. In vivo, HEA-3 stimulated by more than 100-fold, the expression of secreted alkaline phosphatase after delivery as plasmid DNA into mouse muscles. Moreover, long-term modulation of the expression of intramuscularly delivered mouse erythropoietin was achieved in immunocompetent mice.
Potential antithyroid agents. 1. N-Alkylformamidino-N-arylthiocarbamide hydrochlorides (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPotential antithyroid agents. 1. N-Alkylformamidino-N-arylthiocarbamide hydrochloridesPramod K. Srivastava, Harendra D. Mishra, and Madhu Bala GuptaCite this: J. Chem. Eng. Data 1979, 24, 4, 381–382Publication Date (Print):October 1, 1979Publication History Published online1 May 2002Published inissue 1 October 1979https://pubs.acs.org/doi/10.1021/je60083a002https://doi.org/10.1021/je60083a002research-articleACS PublicationsRequest reuse permissionsArticle Views36Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Throughput and Fairness maximization in Wireless Networks (2007)

In this paper, a single-antenna broadcast channel with large (K) number of users is considered. It is assumed that all users have a hard delay constraint D. We propose a scheduling algorithm for maximizing the throughput of the system, while satisfying the delay constraint for all users. It is proved that by using the proposed algorithm, it is possible to achieve the maximum throughput and minimum delay in the network, simultaneously, in the asymptotic case of K rarr co. We introduce a new notion of fairness in the network, called " <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">minimum average throughput</i> ", and prove that the proposed algorithm maximizes the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">minimum average throughput</i> in a broadcast channel. Finally, the proposed algorithm is generalized for MIMO broadcast channels (MIMO-BC).
Gymnothorax baranesi, a new moray eel (Anguilliformes: Muraenidae) from the Red Sea (2008)

Smith, David G., Brokovich, Eran, Einbinder, Shai (2008): Gymnothorax baranesi, a new moray eel (Anguilliformes: Muraenidae) from the Red Sea. Zootaxa 1678: 63-68, DOI: 10.5281/zenodo.180363
Efficient light trapping structure in thin film silicon solar cells (2010)

Thin film silicon solar cells are believed to be promising candidates for continuing cost reduction in photovoltaic panels because silicon usage could be greatly reduced. Since silicon is an indirect bandgap semiconductor, its absorption coefficient is low for photons in the wavelength ranges between 600nm and 1100nm. For high efficiency thin film modules, effective light trapping is essential. Traditional schemes such as textured transparent conductive oxide (TCO) and metal reflector have several disadvantages such as enhanced surface recombination, parasitic losses at the TCO/metal interface, and the lack of ability to control and optimize the textured surface. We have previously proposed to employ a light trapping structure, which combines a self-assembled submicron grating and a distributed Bragg reflector (DBR) on the backside of thin film silicon solar cells. The DBR works as a one-dimensional photonic crystal to obtain almost 100% reflectivity. The grating scatters the incident light into oblique angles to significantly enhance the optical path length. Numerical calculations predict that by optimizing the feature sizes of the grating and DBR, up to 31% relative efficiency increase can be obtained, compared to the bare thin film Si. By using self-assembly, the organized grating structure can be formed spontaneously at a much lower cost. Current-voltage relations and quantum efficiency measurements were taken to verify the performance of our designed back structure. In the wavelength range of 600-900nm, photon absorption is greatly enhanced. As a result, more than 20% relative efficiency enhancement is achieved for 1.5um thin film silicon cells. These numerical and experimental results show that a light trapping design can be low-cost and increase efficiencies for high performance thin film Si solar cells.
Induced-charge electro-osmosis around metal and Janus spheres in water: Patterns of flow and breaking symmetries (2014)

We establish experimentally the flow patterns of induced-charge electro-osmosis around immobilized metallic spheres in aqueous electrolyte. The ac field modifies local electrolyte concentration and causes quadrupolar flows with inward velocities being smaller than the outward ones. At high fields, the flow becomes irregular, with vortices smaller than the size of the sphere. Janus metallodielectric spheres create dipolar flows and pump the fluid from the dielectric toward the metallic part. The experimentally determined far-field flows decay with distance as r^{-3}.
Imaging in Photodynamic Therapy (2017)

Deeper characterization of signaling pathways important in glioma growth is needed and may enable the development of new pharmacological agents, which could be utilized in new therapies for patients who do not respond to conventional antitumor therapies. Protein kinase B (PKB/Akt) and the transcription factor, nuclear factor kappa B (NF-kappaB), have garnered attention as potential targets for cell death induction and sensitization to chemotherapy in many tumor cell types such as lung cancer, ovarian cancer, and glioblastoma (Aggarwal, 2004; Kapoor et al., 2004; Sethi et al., 2007; Wu et al., 2008; Xu et al., 2009; Koul et al., 2010; Zanotto-Filho et al., 2010).