gebhart/patrepeval huggingface dataset:
High temporal & spatial resolution imaging of catastrophic & soft breakdown in self-assembled nanodielectrics (SANDs) films (2017)

Breakdown processes in polymer dielectrics pose a limitation to energy storage and high-power operation of many electronic devices. These processes have been studied for many decades, and a great deal of progress has been made in developing phenomenological models [1]. Nonetheless, many open questions remain, particularly regarding the development of a single, unified theory to describe all stages of the breakdown process, from initiation, to sub-critical filament advance, to catastrophic breakdown and/or “soft breakdown” [2]. To develop and validate such a detailed understanding, it is essential to first develop high-speed, spatially-resolved in situ characterization techniques. Here we demonstrate that thermoreflectance imaging [3-5] can provide such a capability for voltage stress-induced defects in self-assembled polymer nanodielectrics (SANDs) films [6]. Temporal evolution of self-heating and material blister formation for soft and catastrophic failure sites in SANDs films are imaged at submicron spatial resolution. This result shows that thermoreflectance characterization techniques provide insight into the breakdown processes determining polymer dielectric performance and reliability.
Synthetic Logic (2014)

The role of inference as it relates to natural language (NL) semantics has often been neglected. Recently, there has been a move away by some NL semanticists from the heavy machinery of, say, Montagovianstyle semantics to a more proof-based approach. Although researchers tend to study each type of system independently, MacCartney (2009) and MacCartney and Manning (2009) (henceforth M&amp;M) recently developed an algorithmic approach to natural logic that attempts to combine insights from both monotonicity calculi and various syllogistic fragments to derive compositionally the relation between two NL sentences from the relations of their parts. At the heart of their system, M&amp;M begin with seven intuitive lexicalsemantic relations that NL expressions can stand in, e.g., synonymy and antonymy, and then ask the question: if ' stands in some lexicalsemantic relation to ; and stands in (a possibly different) lexicalsemantic relation to ✓; what lexical-semantic relation (if any) can be concluded about the relation between ' and ✓? This type of reasoning has the familiar shape of a logical inference rule. However, the logical properties of their join table have not been explored in any real detail. The purpose of this paper is to give M&amp;M’s table a proper logical treatment. As I will show, the table has the underlying form of a syllogistic fragment and relies on a sort of generalized transitive reasoning.
Transmission of 30-GBd polarization-multiplexed probabilistically shaped 4096-QAM over 509-km SSMF (2019)

We demonstrate the transmission of a 30-GBd polarization-multiplexed probabilistically shaped 4096-ary quadrature amplitude modulation (QAM) signal over 50.9-km standard signal-mode fiber (SSMF), with a net single-carrier bit rate of 484.4 Gb/s carrying 16.1 information bits per symbol (a potential spectral efficiency of 15.9 bits/s/Hz when taking into account a 0.01 spectral roll-off). The signal is generated from 28-nm complementary metal-oxide-semiconductor (CMOS) digital-to-analog converters (DACs) with 8-bit nominal resolution and is received by an intradyne coherent receiver with a laser that has a linewidth of ∼1 kHz.
V07-02 URETHRAL BULKING WITH NATIVE TISSUE FOR FRAIL URETHRAS DURING ARTIFICIAL URINARY SPHINCTER SURGERY (2023)

You have accessJournal of UrologyCME1 Apr 2023V07-02 URETHRAL BULKING WITH NATIVE TISSUE FOR FRAIL URETHRAS DURING ARTIFICIAL URINARY SPHINCTER SURGERY William Du Comb, Nora Haney, Matthew Rabinowitz, James Liu, and Arthur Burnett William Du CombWilliam Du Comb More articles by this author , Nora HaneyNora Haney More articles by this author , Matthew RabinowitzMatthew Rabinowitz More articles by this author , James LiuJames Liu More articles by this author , and Arthur BurnettArthur Burnett More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003288.02AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The artificial urinary sphincter (AUS) has long been the ideal surgical treatment option for men with stress urinary incontinence (SUI) and has excellent patient satisfaction rates. However, revision rates remain as high as 50%. We describe our use of native periurethral tissue as a urethral bulking technique in patients with frail urethras during AUS surgery. METHODS: An AUS is inserted or revised in the usual standard fashion. The state of the urethral tissue is inspected, and the circumference is measured. When the urethral circumference is less than 4 cm or the urethral tissue is frail, periurethral tissue bulking is performed. Dissection of the bulbospongiosus muscle is carried out at the level of the bulbar urethra, incorporating it with a circumferential measurement. In the event the bulbospongiosus muscle is inadequate for bulking, the proximal corpus spongiosum is mobilized distally as a ventral flap, beneath the circumferential measurement. The AUS size is then selected. RESULTS: Using native periurethral tissue for urethral bulking can add up to 1 cm in cuff size when placing an AUS in patients with frail urethras. Patient satisfaction rates remain high, and there has been no documented device erosion with our technique. CONCLUSIONS: We have demonstrated an alternative approach to urethral bulking with native periurethral tissue in patients undergoing AUS placement who are found to have frail urethras. Urethral bulking with native tissue provides a durable alternative to transcorporal cuff placement or tandem cuffs to establish proper coaptation. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e596 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information William Du Comb More articles by this author Nora Haney More articles by this author Matthew Rabinowitz More articles by this author James Liu More articles by this author Arthur Burnett More articles by this author Expand All Advertisement PDF downloadLoading ...
Quality by Design Considerations (2019)

Quality by design has been both a development and regulatory objective since the turn of the Millennium. Inhaled medicines are complex products for which each component requires scrutiny with respect to impact on the important performance measures of delivered dose and aerodynamic particle size. The compounding of error arising from any variability in the active pharmaceutical ingredient, the formulation, the metering system, the device, and any auxiliary attachments, requires exquisite control if performance is to be maintained within reasonable limits. This chapter considers the target product profile on which development is based, the critical quality attributes that must be monitored and controlled, and concludes with risk management and assessment that derive from an understanding of a specific process and product. All factors can then be used as the foundation for lifecycle management and continual improvement to the product.
Suspended metal wire array as a thermoacoustic sound source (2009)

We demonstrate that a suspended metal wire array can be used to produce high-pressure sound waves over a wide spectrum using the thermoacoustic effect. We fabricated air-bridge arrays containing up to 2×105 wires covering an area of a few square centimeters. The supporting silicon wafer was isotropically plasma etched to release the wires thereby avoiding heat contact with the substrate. Sound pressure levels reaching 110 dB at a distance of 8 cm were demonstrated near 40 kHz in free field. The devices are also able to reproduce music and speech. They have potential for applications especially in the ultrasound range.
Physical Layer Latency Management Mechanisms: A Study for Millimeter-Wave Wi-Fi (2021)

Emerging applications in fields such as extended reality require both a high throughput and low latency. The millimeter-wave (mmWave) spectrum is considered because of the potential in the large available bandwidth. The present work studies mmWave Wi-Fi physical layer latency management mechanisms, a key factor in providing low-latency communications for time-critical applications. We calculate physical layer latency in an ideal scenario and simulate it using a tailor-made simulation framework, based on the IEEE 802.11ad standard. Assessing data reception quality over a noisy channel yielded latency’s dependency on transmission parameters, channel noise, and digital baseband tuning. Latency in function of the modulation and coding scheme was found to span 0.28–2.71 ms in the ideal scenario, whereas simulation results also revealed its tight bond with the demapping algorithm and the number of low-density parity-check decoder iterations. The findings yielded tuning parameter combinations for reaching Pareto optimality either by constraining the bit error rate and optimizing latency or the other way around. Our assessment shows that trade-offs can and have to be made to provide sufficiently reliable low-latency communication. In good channel conditions, one may benefit from both the very high throughput and low latency; yet, in more adverse situations, lower modulation orders and additional coding overhead are a necessity.
A 1024-QAM Capable WLAN Receiver with -56.3dB Image Rejection Ratio Using Self-Calibration Technique (2018)

This paper presents a 1024-QAM OFDM signal capable WLAN receiver in 65nm CMOS technology. Thermal noise-based IQ frequency-independent mismatch correction and IQ frequency-dependent mismatch correction with baseband loopback are proposed for the self-calibration in the receiver. The measured image rejection ratio of the self-calibration is -56.3dB. The receiver achieves the extremely low EVM of -37.1dB even with wide channel bandwidth of 80MHz and has the ability to receive the 1024-QAM signal. The result indicates that the receiver is extendable for the 802.11ax compliant receiver that supports a higher density modulation scheme of MIMO.
Human Lineage-Specific Transcriptional Regulation through GA-Binding Protein Transcription Factor Alpha (GABPa) (2016)

A substantial fraction of phenotypic differences between closely related species are likely caused by differences in gene regulation. While this has already been postulated over 30 years ago, only few examples of evolutionary changes in gene regulation have been verified. Here, we identified and investigated binding sites of the transcription factor GA-binding protein alpha (GABPa) aiming to discover cis-regulatory adaptations on the human lineage. By performing chromatin immunoprecipitation-sequencing experiments in a human cell line, we found 11,619 putative GABPa binding sites. Through sequence comparisons of the human GABPa binding regions with orthologous sequences from 34 mammals, we identified substitutions that have resulted in 224 putative human-specific GABPa binding sites. To experimentally assess the transcriptional impact of those substitutions, we selected four promoters for promoter-reporter gene assays using human and African green monkey cells. We compared the activities of wild-type promoters to mutated forms, where we have introduced one or more substitutions to mimic the ancestral state devoid of the GABPa consensus binding sequence. Similarly, we introduced the human-specific substitutions into chimpanzee and macaque promoter backgrounds. Our results demonstrate that the identified substitutions are functional, both in human and nonhuman promoters. In addition, we performed GABPa knock-down experiments and found 1,215 genes as strong candidates for primary targets. Further analyses of our data sets link GABPa to cognitive disorders, diabetes, KRAB zinc finger (KRAB-ZNF), and human-specific genes. Thus, we propose that differences in GABPa binding sites played important roles in the evolution of human-specific phenotypes.
Fluorophilic (2016)

In the past, aggregation and self-assembly have been associated principally with micellar and colloidal systems of molecules; however, with the advent of supramolecular chemistry, molecular self-assembly has been opened to a much wider understanding that has facilitated access to a variety of different shapes and sizes, along with the construction of new and fascinating molecular topologies. This document aims at defining more than 150 terms related to aggregation and self-assembly in the particular case of macromolecules. The list is restricted to the most commonly encountered terms.
Multi-spectral Pedestrian Detection via Image Fusion and Deep Neural Networks (2018)

The use of multi-spectral imaging has been found to improve the accuracy of deep neural network-based pedestrian detection systems, particularly in challenging night time conditions in which pedestrians are more clearly visible in thermal long-wave infrared bands than in plain RGB. In this article, the authors use the Spectral Edge image fusion method to fuse visible RGB and IR imagery, prior to processing using a neural network-based pedestrian detection system. The use of image fusion permits the use of a standard RGB object detection network without requiring the architectural modifications that are required to handle multi-spectral input. We contrast the performance of networks trained using fused images to those that use plain RGB images and networks that use a multi-spectral input. © 2018 Society for Imaging Science and Technology.
Developable mechanisms on developable surfaces (2019)

Developable mechanisms are proposed as next-generation mechanical systems that can conform to and emerge from developable surfaces.
Particle Transport, Deposition And Removal From Research To Curriculum Development (2020)

Abstract NOTE: The first page of text has been automatically extracted and included below in lieu of an abstract Particle Transport, Deposition and Removal- From Research to Curriculum Development Goodarz Ahmadi,1 Suresh Dhaniyala,1 John McLaughlin,1 Cetin Cetinkaya,1 Stephen Doheny-Farina,1 and Fa-Gung Fan2 1 Clarkson University, Potsdam, NY, 13699-5725, USA 2 Xerox Corporation, Webster, NY, 14580, USA Abstract Understanding particle transport, deposition and removal are of crucial importance to many technologies such as microelectronic, imaging and pharmaceutical industries. In addition, solving a number of environmental problems requires a detail understanding of particle transport processes. In the last decade, significant research progress in the areas of particle transport, deposition and removal has been made. In this “combined research and curriculum development” project a sequence of two new courses on particle transport, deposition and removal and re-entrainment was developed and an existing course was fully revised to bring these new important research findings to seniors and first year graduate students in engineering. The course materials were made available on the web and the course was taught at two campuses simultaneously. A series of short courses were also offered to industries and at universities and research centers in the US and abroad. Introduction Particle transport, deposition and removal are the key in many technologies that are of critical importance to the competitiveness of US industries, as well as in a number of environmental processes. Last decade has seen development of significant computational as well as experimental tools for studies of particle transport, deposition and removal. The primary objective of this combined research and curriculum development project is to make the fruits of these new important research findings available to seniors and first year graduate students in engineering through developing and offering of sequence of specialized courses. In these courses, the processes of particle transport, deposition and removal and re-entrainment were described. A comprehensive web for these courses was developed, and the courses were taught simultaneously at Clarkson University and Syracuse University. Course Modules These combined research and curriculum development (CRCD) courses are composed of four modules. These are: Fundamental of particle transport, dispersion, deposition and removal. Computational modeling of particle transport, deposition and removal. 1
Search for Structure in the B[superscript 0][subscript s]π[superscript ±] Invariant Mass Spectrum (2016)

The B[superscript 0][subscript s]π[superscript ±] invariant mass distribution is investigated in order to search for possible exotic meson states. The analysis is based on a data sample recorded with the LHCb detector corresponding to 3 fb[superscript -1] of pp collision data at √[s=7 and 8 TeV. No significant excess is found, and upper limits are set on the production rate of the claimed X(5568) state within the LHCb acceptance. Upper limits are also set as a function of the mass and width of a possible exotic meson decaying to the B[superscript 0][subscript s]π[superscript ±] final state. The same limits also apply to a possible exotic meson decaying through the chain B[superscript *0][subscript 2]π[superscript ±], B[subscript *0][subscript s]→B[subscript 0][subscript 2]γ where the photon is excluded from the reconstructed decays.
A Network of Magnetometers for Multi-Scale Urban Science and Informatics (2018)

Abstract. The magnetic signature of an urban environment is investigated using a geographically distributed network of fluxgate magnetometers deployed in and around Berkeley, California. The system hardware and software are described and initial operations of the network are reported. The sensors measure vector magnetic fields at a 3,960 Hz sample rate and are sensitive to 0.1 nT / √Hz. Data from individual stations are synchronized to ± 120 μs using GPS and computer system clocks and automatically uploaded to a central server. We present the initial observations of the network as well as preliminary efforts to correlate sensors. A wavelet analysis is used to study observations of the urban magnetic field over a wide range of temporal scales. The Bay Area Rapid Transit (BART) is identified as dominant signal in our observations, exhibiting both aspects of broadband noise and coherent periodic features. Significant differences are observed in both day/night and weekend/weekday signatures. A superposed epoch analysis is used to study and extract the BART signal.
Contributions of Telomerase to Tumorigenesis (2007)

In eukaryotic cells, the telomere acts as a molecular cap, protecting the chromosome ends and preventing end-to-end fusions. In addition to this end protection function, dysfunctional telomeres limit replicative potential by inducing a non-proliferative state termed replicative senescence. In premalignant cells, telomere loss results in genomic instability, which promotes the formation and selection of pro-tumorigenic mutations. Telomeres are maintained by the reverse transcriptase telomerase, an enzyme whose activity is tightly controlled by limiting the expression of the catalytic subunit, telomerase reverse transcriptase (TERT). The majority of human tumors exhibit abundant telomerase activity, which protects the chromosome ends to prevent additional genomic instability and confers unlimited replicative potential. This unique biochemical activity is vital to tumorigenesis and presents an ideal target for potential pharmacologic and immunologic therapies.
The African Swine Fever Virus DP71L Protein Recruits the Protein Phosphatase 1 Catalytic Subunit To Dephosphorylate eIF2α and Inhibits CHOP Induction but Is Dispensable for These Activities during Virus Infection (2010)

The African swine fever virus (ASFV) DP71L protein is present in all isolates as either a short form of 70 to 72 amino acids or a long form of about 184 amino acids, and both of these share sequence similarity to the C-terminal domain of the herpes simplex virus ICP34.5 protein and cellular protein GADD34. In the present study we expressed DP71L in different mammalian cells and demonstrated that DP71L causes dephosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α) in resting cells and during chemical-induced endoplasmic reticulum stress and acts to enhance expression of cotransfected reporter genes. We showed that DP71L binds to all the three isoforms (α, β, and γ) of the protein phosphatase 1 catalytic subunit (PP1c) and acts by recruiting PP1c to eIF2α. We also showed that DP71L inhibits the induction of ATF4 and its downstream target, CHOP. We investigated the eIF2α phosphorylation status and induction of CHOP in porcine macrophages infected by two ASFV field isolates, Malawi Lil20/1 and Benin 97/1, and two DP71L deletion mutants, MalawiΔNL and E70ΔNL. Our results showed that deletion of the DP71L gene did not cause an increase in the level of eIF2α phosphorylation or induction of CHOP, indicating that DP71L is not the only factor required by the virus to control the phosphorylation level of eIF2α during infection. We therefore hypothesize that ASFV has other mechanisms to prevent the eIF2α phosphorylation and the subsequent protein synthesis inhibition.
Sensory neurone‐specific receptor‐mediated regulation of micturition reflex in urethane‐anaesthetized rats (2011)

• These results indicate that in urethane-anaesthetized rats activation of SNSRs can inhibit the micturition reflex via pathways independent of capsaicin-sensitive C-fibres. • Thus SNSRs could be a potential target for the treatment of bladder dysfunction, e.g. overactive bladder.
Pouchitis Is Associated with Mucosal Imbalance Between Interleukin-8 and Interleukin-10 (2000)

Histologic lesions of pouchitis are associated with a mucosal imbalance between IL-8 and IL-10. IL-10 could be proposed as a new treatment for pouchitis.
Entropy‐Driven Chemisorption of NOx on Phosphotungstic Acid (2012)

Free-energy calculations indicated that the NO(x) adsorption process on heteropolyacids is entropy-driven, as more gas molecules are released than adsorbed by substitution of H(5)O(2)(+) with NO(+) species. P yellow, W light blue, O red, H pink, N small dark blue spheres.
Synthesis of Nono-coral like colloidal particles via water in oil miniemulsion. (2013)

International audience
Issues in nonuniform filter banks (2000)

This paper concerns biorthogonal filter banks. It is shown that a tree structured filter bank is biorthogonal if it is equivalent to a tree structured filter bank whose matching constituent levels on the analysis and synthesis sides are themselves biorthogonal pairs. We then show that a stronger statement can be made about dyadic Filter Banks in general: That a dyadic filter bank is biorthogonal if both the analysis and synthesis banks can be decomposed into dyadic trees. We further show that these decompositions are stability preserving. These results thus generalize earlier comparable results for orthogonal filter banks.
Multiple scattering anisotropy contrast using localization-diverse OCT (2021)

Multiple scattering and angle-dependent scattering anisotropy confound interrogation of tissues with OCT and are generally considered noise. Here we characterize a new localization-diverse OCT system that measures the scattering through a pair of neighboring locations. By varying the offset and direction between the locations, we could distinguish single- from multiple-scattering in tissue-mimicking scattering phantoms. This system has the potential to detect previously unobserved tissue anisotropy by leveraging localization diversity in OCT.