gebhart/patrepeval huggingface dataset:
EVALUATION OF THE DIELECTRIC STRENGTH BEHAVIOR OF RUBBER BLENDS USING FEED-FORWARD NEURAL NETWORK IN DIFFERENT ENVIRONMENTAL CONDITIONS (2022)

Polymers have been frequently employed in electrical applications because of their strong thermal and electrical insulating qualities, low density, and chemical resistance. In this study, a comparison between the behaviour and electrical properties of polymer blends and the results of artificial neural network (ANN) modelling has been conducted. Five samples of silicon rubber (SiR) and ethylene propylene diene monomer (EPDM) were prepared in different proportions. A dielectric test was used to test the dielectric performance of insulation samples under various polluting conditions such as dry, wet, low salinity, and high salinity wet according to ASTM standards. Percentage of blend and dielectric strength were used by ANN modelling for varying ambient conditions. The observations on ANN results and the experimental results have shown sufficient accuracy mutually. The artificial intelligence modelling studies for this article prove the applicability of the behavioural and electrical properties of EPDM/SiR blends. These findings indicate that artificial neural networks can be a useful tool for conducting experiments on the behaviour and electrical properties of polymer materials. يهدف هذه البحث إلى دراسة تأثير شدة العزل الکهربي للعازالت من مادة البوليمر المولفة من المطاط ومنها السليکون المطاطي وااليثيلين بروبلين دايين مون ومر في الظروف البيئية المختلفة ومحاکاة النتائج المعملية باستخدام شبکة التغذية االمامية العصبية. تم دراسة أداء العينات المختلفة من حيث مقدار شدة العزل الکهربي عند الحالة الجافة والحالة الرطبة وعند بيئة منخفضة الملوحة وأيضا بيئة عالية الملوحة. تم تحضير خمس عينات مختلفة من خلطات SiR-EPDM ( 100/0 ؛ 75/25 ؛ 50/50 ؛ 25 /75 ؛ 0/100 .)تم قياس جهد وفقً ASTM .تم استخدام البيانات التجريبية لتدريب نموذج االنهيار )BDV )تحت هذه الظروف البيئية في معمل الجهد العالي ا لمعايير ANN .تمثل نسبة المزج والحالة الجافة والحالة الرطبة والحالة منخفضة الملوحة والحالة عالية الملوحة الدخل لـ FFNN بينما يمثل جهد االنهيار الخرج. تمت مقارنة المخرجات التي تم الحصول عليها من ANN وفحصها مقابل البيانات التي تم الحصول عليها في المختبر. تشير هذه الدراسة إلى أنه يمکن الوثوق بـ ANN لمحاکاة تأثير الظروف البيئية المختلفة على جهد االنهيار للعينات العازلة بمعدل مر ٍض. کما يوضح أي ًضا أن محاکاة ANN هي أداة فعالة يمکن اعتمادها کمرجع لتقليل الوقت والتکلفة الالزمين إلعداد العينات واختبارها في المعمل.
Conditional Modeling and the Jitter Method of Spike Re-sampling:\n Supplement (2011)

This technical report accompanies the manuscript "Conditional Modeling and\nthe Jitter Method of Spike Re-sampling." It contains further details, comments,\nreferences, and equations concerning various simulations and data analyses\npresented in that manuscript, as well as a self-contained Mathematical Appendix\nthat provides a formal treatment of jitter-based spike re-sampling methods.\n
Effects of Cognitive Behavioral Stress Management Delivered by a Virtual Human, Teletherapy, and an E-Manual on Psychological and Physiological Outcomes in Adult Women: An Experimental Test (2022)

Technology may expand the reach of stress management to broader populations. However, issues with engagement can reduce intervention effectiveness. Technologies with highly social interfaces, such as virtual humans (VH), may offer advantages in this space. However, it is unclear how VH compare to telehealth and e-manuals at delivering psychological interventions. This experiment compared the effects of single laboratory session of Cognitive Behavioral Stress Management (CBSM) delivered by a VH (VH-CBSM), human telehealth (T-CBSM), and an e-manual (E-CBSM) on psychological and physiological outcomes in a community sample of stressed adult women. A pilot randomized controlled trial (RCT) with a parallel, mixed design was conducted. Adult women (M age =43.21, SD = 10.70) who self-identified as stressed were randomly allocated to VH-CBSM, T-CBSM, or E-CBSM involving one 90 min session and homework. Perceived stress, stress management skills, negative affect, optimism, relaxation, and physiological stress were measured. Mixed factorial ANOVAs and pairwise comparisons with Bonferroni correction investigated main and interaction effects of time and condition. Participants’ data (N = 38) were analysed (12 = VH-CBSM; 12 = T-CBSM; 14 = E-CBSM). Each condition significantly improved stress, negative affect, optimism, relaxation, and physiological stress over time with large effect sizes. No significant differences were found between conditions on outcomes. Overall, all three technologies showed promise for remotely delivering CBSM in a controlled setting. The findings suggest feasibility of the VH-CBSM delivery approach and support conducting a fully powered RCT to examine its effectiveness when delivering a full 10-week CBSM intervention.
Plasmonic‐Tuned Flash Cu Nanowelding with Ultrafast Photochemical‐Reducing and Interlocking on Flexible Plastics (2017)

Herein, a high‐performance copper nanowire (Cu NW) network (sheet resistance ≈ 17 Ω sq −1 , transmittance 88%) fabricated by plasmonic‐tuned flash welding (PFW) with ultrafast interlocking and photochemical reducing is reported, which greatly enhance the mechanical and chemical stability of Cu NWs. Xenon flash spectrum is tuned in an optimized distribution (maximized light intensity at 600 nm wavelength) through modulation of electron kinetic energy in the lamp by generating drift potential for preferential photothermal interactions. High‐intensity visible light is emitted by the plasmonic‐tuned flash, which strongly improves Cu nanowelding without oxidation. Near‐infrared spectrum of the flash induced an interlocking structure of NW/polyethylene terephthalate interface by exciting Cu NW surface plasmon polaritons (SPPs), increasing adhesion of the Cu nanonetwork by 208%. In addition, ultrafast photochemical reduction of Cu NWs is accomplished in air by flash‐induced electron excitations and relevant chemical reactions. The PFW effects of localized surface plasmons and SPPs on junction welding and adhesion strengthening of Cu network are theoretically studied as physical behaviors by finite‐difference time‐domain simulations. Finally, a transparent resistive memory and a touch screen panel are demonstrated by using the flash‐induced Cu NWs, showing versatile and practical uses of PFW‐treated Cu NW electrodes for transparent flexible electronics.
Catalytically impaired TrpA subunit of tryptophan synthase from Chlamydia trachomatis is an allosteric regulator of TrpB (2021)

Intracellular growth and pathogenesis of Chlamydia species is controlled by the availability of tryptophan, yet the complete biosynthetic pathway for l-Trp is absent among members of the genus. Some representatives, however, preserve genes encoding tryptophan synthase, TrpAB - a bifunctional enzyme catalyzing the last two steps in l-Trp synthesis. TrpA (subunit α) converts indole-3-glycerol phosphate into indole and glyceraldehyde-3-phosphate (α reaction). The former compound is subsequently used by TrpB (subunit β) to produce l-Trp in the presence of l-Ser and a pyridoxal 5'-phosphate cofactor (β reaction). Previous studies have indicated that in Chlamydia, TrpA has lost its catalytic activity yet remains associated with TrpB to support the β reaction. Here, we provide detailed analysis of the TrpAB from C. trachomatis D/UW-3/CX, confirming that accumulation of mutations in the active site of TrpA renders it enzymatically inactive, despite the conservation of the catalytic residues. We also show that TrpA remains a functional component of the TrpAB complex, increasing the activity of TrpB by four-fold. The side chain of non-conserved βArg267 functions as cation effector, potentially rendering the enzyme less susceptible to the solvent ion composition. The observed structural and functional changes detected herein were placed in a broader evolutionary and genomic context, allowing identification of these mutations in relation to their trp gene contexts in which they occur. Moreover, in agreement with the in vitro data, partial relaxation of purifying selection for TrpA, but not for TrpB, was detected, reinforcing a partial loss of TrpA functions during the course of evolution.
A novel thermolytic annulation of an oxazolidinone: an enantiospecific synthesis of (-)-slaframine (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA novel thermolytic annulation of an oxazolidinone: an enantiospecific synthesis of (-)-slaframineMukund P. Sibi, James W. Christensen, Biqin Li, and Paul A. RenhoweCite this: J. Org. Chem. 1992, 57, 16, 4329–4330Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/jo00042a002https://doi.org/10.1021/jo00042a002research-articleACS PublicationsRequest reuse permissionsArticle Views251Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Characteristics of Cases with Poor Transcranial Motor-evoked Potentials Baseline Waveform Derivation in Spine Surgery (2021)

Study Design. Prospective multicenter study. Objective. The purpose of the study is to examine cases with poor baseline waveform derivation for all muscles in multichannel monitoring of transcranial motor-evoked potentials (Tc-MEPs) in spine surgery. Summary of Background Data. Intraoperative neuromonitoring (IONM) is useful for identifying neurologic deterioration during spinal surgery. Tc-MEPs are widely used for IONM, but some cases have poor waveform derivation, even in multichannel Tc-MEP monitoring. Methods. The subjects were 3625 patients (mean age 60.1 years, range 4–95; 1886 females, 1739 males) who underwent Tc-MEP monitoring during spinal surgery at 16 spine centers between April 2017 and March 2020. Baseline Tc-MEPs were recorded from the deltoid, abductor pollicis brevis, adductor longus, quadriceps femoris, hamstrings, tibialis anterior, gastrocnemius, and abductor hallucis (AH) muscles after surgical exposure of the spine. Results. The 3625 cases included cervical, thoracic, and lumbar lesions (50%, 33% and 17%, respectively) and had preoperative motor status of no motor deficit, and motor deficit with manual muscle testing (MMT) ≥3 and MMT &lt;3 (70%, 24% and 6%, respectively). High-risk surgery was performed in 1540 cases (43%). There were 73 cases with poor baseline waveform derivation (2%), and this was significantly associated with higher body weight, body mass index, thoracic lesions, motor deficit of MMT &lt;3, high-risk surgery (42/1540 [2.7%] vs. 31/2085 [1.5%], P &lt; 0.05), and surgery for ossification of the posterior longitudinal ligament (OPLL). Intraoperative waveform derivation occurred in 25 poor derivation cases (34%) and the AH had the highest rate. Conclusion. The rate of poor baseline waveform derivation in spine surgery was 2% in our series. This was significantly more likely in high-risk surgery for thoracic lesions and OPLL, and in cases with preoperative severe motor deficit. In such cases, it may be preferable to use multiple modalities for IONM to derive multichannel waveforms from distal limb muscles, including the AH. Level of Evidence: 3
Multidimensional Simulation of Threshold Switching in NbO2 Based on an Electric Field Triggered Thermal Runaway Model (2016)

Volatile threshold switching devices have attracted great attention for use as selectors in passive crossbar arrays. These devices show an abrupt hysteretic jump in the current–voltage characteristic and thus offer very high selectivity. As this nonlinearity appears for either voltage polarity, threshold switches are an ideal selector for bipolar‐switching redox‐based resistive memories. To date, the predominant explanation of the threshold‐switching phenomenon in NbO 2 and related materials is the insulator‐to‐metal transition that occurs at a certain temperature and is connected to a phase transition. However, some essential experimental findings are not satisfactorily explained. Here, a multidimensional simulation of the threshold switching in NbO 2 is presented that overcomes these shortcomings. The model is based on an electric field‐induced thermal runaway that increases the amount of mobile charge carriers in the device. Applying this model in a simulation correctly predicts the experimentally observed threshold‐type current–voltage characteristic, inclusive of important features like the narrow opening of the hysteresis and the magnitude of the current jump. Furthermore, the simulation enables to discuss different influencing parameters independently at spatial resolution. The model is also applicable to a wider class of materials showing the threshold switching, but does not show a temperature‐induced insulator‐to‐metal transition.
High-performance 40 Gbit/s fibre Bragg grating tunable dispersion compensator fabricated using group delay ripple correction technique (2003)

A recently proposed UV correction method is used to reduce group delay ripple in a chirped fibre grating tunable dispersion compensator. In 43 Gbit/s CSRZ system tests, the corrected grating had less than 0.5 dB OSNR penalty over the tunable dispersion range of 270 to 750 ps/nm.
Organization of the 5S ribosomal RNA genes in the genome of tomato (1991)

The 5S ribosomal RNA (rRNA) genes represent one of the most abundant gene families in eukaryotic genomes and have been a model system for the study of molecular organization and evolution of multigene families in eukaryotes. This paper reports a detailed characterization of the 5S rRNA genes of tomato (Lycopersicon esculentum) with respect to chromosome assignment, chromosomal localization, copy number, and physical size. By restriction fragment length polymorphism, the tandemly repeated 5S rRNA genes were assigned to a region of chromosome 1 of tomato. These results were confirmed by in situ hybridization onto tomato metaphase chromosomes. The single hybridization signal was localized to the short arm of chromosome 1, in a region close to the centromere. Based on reconstruction experiments, it was estimated that the 400-bp repeating unit occurs in approximately 1000 copies per haploid genome. Physical characterization of the entire locus was then performed by means of pulsed-field gel electrophoresis. Digestion of high molecular weight DNA of tomato with restriction enzymes such as PvuII, ClaI, and BglII resulted in a very prominent band with a size between approximately 450 and 600 kb. This value closely matched the estimated size of the gene cluster based on reconstruction experiments. The data therefore suggest that all the 5S rRNA genes in tomato occur in a single, continuous array, uninterrupted by unrelated sequences.Key words: 5S rRNA genes, organization, Lycopersicon esculentum, in situ hybridization, pulsed-field gel electrophoresis.
UNDERSTANDING INDOCYANINE GREEN ANGIOGRAPHY IN POLYPOIDAL CHOROIDAL VASCULOPATHY (2014)

Both systems detected >80% of PCV based on typical nodular appearance of polyps. However, the cSLO is superior in detecting additional features, particularly branching vascular network.
Gene Transfer for Adult CNS Regeneration and Aging (1998)

Neuronal degeneration is a common feature of numerous neurological disorders and of aging. Following experimental or pathologic injury of the adult mammalian central nervous system (CNS), a complex cascade of events takes place that often results in severe anatomical and functional deficits Unlike neurons of the peripheral nervous system (PNS) or neurons of the developing CNS, the mature CNS displays a very limited capacity to extend axons and form appropriate connections, resulting in little constructive regeneration after damage. Studies of the developing and adult PNS have suggested that the adult CNS may be capable of achieving some degree of recovery if three critical steps are satisfied: survival or replacement of local damaged neurons, axonal growth and extension, and appropriate target innervation and functional recovery.
L’immunothérapie de l’infection par le VIH (2002)

L’objectif du traitement par immunothérapie de l’infection par le VIH a pour but de favoriser le renouvellement et la mobilisation des lymphocytes T CD4, de diminuer la destruction de ces cellules soit par apoptose, soit par le virus et de rétablir le réseau perturbé des cytokines et une fonction lymphocytaire T normale notamment vis-à-vis du VIH. Une immunothérapie de l’infection par le VIH pourrait participer à la suppression de la réplication virale, prévenir la réplication virale et agir de manière synergique avec les antiviraux dans le contrôle de cette réplication par l’élimination des cellules infectées complétant ainsi leur action. Enfin, le but ultime d’une stratégie d’immunothérapie pourrait être, par le renforcement de la réponse immunitaire spécifique, l’allègement et/ou l’interruption des traitements antirétroviraux en raison de leur toxicité dans le long terme.
A follicle-stimulating-hormone secreting pituitary adenoma treated with long acting repeatable bromocriptine. (1990)

peer reviewed
A Dynamic-System-Based Approach to Modeling Driver Movements Across General-Purpose/Managed Lane Interfaces (2018)

To help mitigate road congestion caused by the unrelenting growth of traffic demand, many transportation authorities have implemented managed lane policies, which restrict certain freeway lanes to certain types of vehicles. It was originally thought that managed lanes would improve the use of existing infrastructure through demand-management behaviors like carpooling, but implementations have often been characterized by unpredicted phenomena that are sometimes detrimental to system performance. The development of traffic models that can capture these sorts of behaviors is a key step for helping managed lanes deliver on their promised gains. Towards this goal, this paper presents an approach for solving for driver behavior of entering and exiting managed lanes at the macroscopic (i.e., fluid approximation of traffic) scale. Our method is inspired by recent work in extending a dynamic-system-based modeling framework from traffic behaviors on individual roads, to models at junctions, and can be considered a further extension of this dynamic-system paradigm to the route/lane choice problem. Unlike traditional route choice models that are often based on discrete-choice methods and often rely on computing and comparing drivers’ estimated travel times from taking different routes, our method is agnostic to the particular choice of physical traffic model and is suited specifically towards making decisions at these interfaces using only local information. These features make it a natural drop-in component to extend existing dynamic traffic modeling methods.
Polyglycolized Saturated Glyceride as a Carrier and Enhancer for Drug Penetration (2001)

In this study, the influence of the melting point and HLB (hydrophile-lipophile balance) value of GelucireR-based formulations on the permeation of model drugs, including prostaglandin E1(PGE1)and its alkyl esters,through the skin barrier was examined. Seven formulations consisting of three grades of Gelucire(44/14, 50/02, and 37/02)at different ratios with the addition of lauroglycol at a fixed ratio of 4:1 to a total Gelucire amount were prepared with model drugs at a concentration of 0.1 mg/mg. For (PGE1), the maximal flux at this concentration was about 35.95 nmole/cm2per h and occurred at the HLB value of 6.6;the melting point ranged from 49to54℃. For the methyl ester of PGE1,the maximal flux appeared to be 76.62 nmole/cm2 per h and occurred at the HLB value5.3;the melting point ranged from 46to50℃.For the methyl ester of PGE1, the maximal flux was around 33.45 nmole/cm2 per hand occurred at the HLB of 5.3;the melting point ranged from 46to50℃.The maximal flux was 15.46 nmol/cm2 per h for the isopropyl ester of PGE1 and appeared at the HLB of 5.3; the melting point ranged from 41 to 48℃.The promotion of penetration for PGE1 and its alkyl esters seemed to be maximized with different Gelucire systems. Results also demonstrate that a higher melting point and a lower HLB value of Gelucire 50/02 resulted in a decreased permeation rate of PGE1 alkyl esters. But the tendency for Gelucire 50/02 and 37/02 to promote the penetration of PGE1 alkyl esters was similar, and the extent of the influence decreased with increased alkyl chain length. This is possibly explained by the fact that Gelucire 50/02 and 37/02 have the same HLB value. Similarly, the influence on drug flux of the HLB value of the Gelucire system was more profound than that of the melting point in this study.
Immunosuppression by T regulatory cells in cows infected with Staphylococcal superantigen (2005)

Our recent study has provided that the in vitro SEC-induced proliferation of bovine T cells is preceded by a period of a non-proliferative immunoregulation of T cells that may be associated with cytokine production regulated by type 1 or type 2 T cells. Inversion of CD4(+):CD8(+) T cell ratio and induction of CD8(+) T cells with immunoregulatory activity could increase the probability of intracellular survival of Staphylococcus aureus (S. aureus). The increase of activated CD8(+)(ACT2(+) BoCD8(+)) T cells in cows with mastitis caused by S. aureus may be associated with immune-regulatory function in the bovine mammary gland. The difference and similarity between bovine activated CD8(+) T cells (CD8(+)CD26(+)) and well-established human CD4(+)CD25(+) T regulatory (Tr) cells may help to reveal their unique immune regulatory system in the host infected with S. aureus.