gebhart/patrepeval huggingface dataset:
Fabrication of polycrystalline cubic boron nitride composites under high pressure (2023)

The PCBN (polycrystalline cubic boron nitride) composites were synthesized by mixing cubic boron nitride micropowders with Ti and Al micropowders at a certain mass ratio under high temperature and ultra-high pressure conditions. Phase composition and microstructure of the samples were analysed by X-ray diffraction and scanning electron microscopy. The effects of sintering temperature on the mechanical properties and microstructure of the PCBN ceramics were investigated. It was shown that BN, AlN, TiN and TiB2 phases coexist in the PCBN ceramics fabricated at ultra-high pressure (5.5GPa) and high temperature (1400-1500?C). With the increase of sintering temperature, pores and gaps inside the PCBN composites gradually disappeared and densified structure was formed. The best comprehensive mechanical properties of the PCBN composites were obtained at 1500 ?C with a flexural strength of 1009MPa and microhardness of 35.8GPa.
Experimental Validation of a 2-D Constriction Resistance Model at the Microscale (2009)

This work proposes and tests the limits of a simplified analytical model of an electrical micro-contact, which considers the resistance of a tapered line taking into account the current crowding effect at the constriction point. We have designed and fabricated micro-constriction patterns with different contact widths, aperture angles, and thicknesses, and correlated their constriction resistances with a 2-D model based on circular electric equipotential lines distributed along a triangle. We also propose an extension of the model, where the resistivity includes the electron loss at the surface of the film and at the grain boundaries. This allows validating the model for film as thin as 35 nm.
Monocyclic Human Tachykinin NK-2 Receptor Antagonists as Evolution of a Potent Bicyclic Antagonist:  QSAR and Site-Directed Mutagenesis Studies (2002)

A new series of monocyclic pseudopeptidic tachykinin NK-2 receptor antagonists has been derived from nepadutant with the help of site-directed mutagenesis studies and QSAR models. MEN11558 is the lead compound which is evaluated on a series of 13 new human tachykinin NK-2 receptor mutants (Tyr107Ala, Gln109Ala, Asn110Ala, Phe112Ala, Ser164Phe, Cys167Gly, Phe168Ala, Tyr169Ala, Ile202Phe, Trp263Ala, Tyr269Phe, Tyr269Ala, and Phe293Ala) and 8 mutants on which data from nepadutant were already available (Gln166Ala, Ser170Ala, Thr171Ala, His198Ala, Tyr206Phe, Tyr266Phe, Tyr289Phe, and Tyr289Thr). The results show that the two compounds share most of their binding sites, in agreement with their hypothesized binding modes. This allows us to transfer the structural knowledge we already had for nepadutant to the new series of compounds. At the same time, a sound QSAR model is developed to assist the prioritization of new chemical syntheses. The result is the discovery of receptor antagonists with a higher affinity than nepadutant for the hNK-2 receptor.
Tumors of the Uterine Corpus and Gestational Trophoblastic Disease (1993)

The American Journal of Surgical Pathology: December 1993 - Volume 17 - Issue 12 - p 1300-1301
ChemInform Abstract: Preparation of 1‐Hydroxycyclopentanecarboxylic Acid Derivatives from a Chiral Equivalent of Glycolic Acid. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Human Supervised Multirotor UAV System Design for Inspection Applications (2018)

Multirotor UAVs are widely used for aerial inspection applications where missions are accomplished either via manual or autonomous control. Human controlled UAVs require trained pilots which can be a barrier from using the technology for general inspection personnel. Fully autonomous navigation, which employs onboard sensing, planning and coverage algorithms, is effective but comes with the cost of development and operational complexities. A human supervised UAV system design is presented where a deployed aerial vehicle operates in semi-autonomous mode. An operator, who is equipped with a smart handheld laser pointer, gives the UAV global guiding directions to reach the inspection target. The UAV is equipped with onboard vision sensing for local planning and target identification in addition to video streaming or recording. System operation is validated in indoor fliaht tests.
Towards blue excitable line emitters (Conference Presentation) (2020)

Narrow band (i.e. line) emitters have an enormous potential for use in LEDs, as they will allow both improvement of color rendering while maintaining high lm/W, and open up new spectral engineering possibilities for specific applications. The major bottle neck for implementation of line emitters in LEDs, is the lack of absorption in the blue spectral region of conventional trivalent lanthanide doped phosphors. In this talk, I will present a new nanoscale approach to engineer phosphor materials, which allows tuning of absorption and emission wavelengths over a wide range of the spectrum. The underlaying mechanism of these engineered phosphors is interparticle energy transfer, which will be discussed in more detail.
Monolithic Microfluidic Cooling of a Heterogeneous 2.5-D FPGA With Low-Profile 3-D Printed Manifolds (2021)

Heterogeneous integration techniques such as 2.5-D system-in-packages (SiPs) present new challenges that include higher aggregate package power as well as increased thermal crosstalk between different chiplets due to their proximity. This creates the need for advanced cooling solutions uniquely catered to these issues. This work presents the first demonstration of monolithic microfluidic cooling of active 2.5-D ICs to mitigate high-power and thermal crosstalk between chiplets. A 2.5-D FPGA package is used for demonstration purposes. Micropin-fin heat sinks etched directly into the backside of five chiplets in the package are supplied with de-ionized water as coolant through 3-D printed manifolds. This approach helps create a low-form factor cooling solution. Design considerations for the polymer manifold as well as micropin-fin etching are discussed. FPGA core temperature was maintained at approximately 30 °C when dissipating nearly 107 W of power, corresponding to a thermal resistance of 0.074 °C/W, and thermal coupling values as low as 0.010 °C/W. We also demonstrate excellent thermal performance even with elevated inlet temperatures for energy-efficient cooling applications.
Sparseloop: An Analytical, Energy-Focused Design Space Exploration Methodology for Sparse Tensor Accelerators (2021)

This paper presents Sparseloop, the first infrastructure that implements an analytical design space exploration methodology for sparse tensor accelerators. Sparseloop comprehends a wide set of architecture specifications including various sparse optimization features such as compressed tensor storage. Using these specifications, Sparseloop can calculate a design's energy efficiency while accounting for both optimization savings and metadata overhead at each storage and compute level of the architecture using stochastic tensor density models. We validate Sparseloop on a well-known accelerator design and achieve ~99% accuracy in terms of runtime activities (e.g., compressed memory accesses). We also present a case study that highlights the key factors (e.g., uncompressed traffic, data density) that affect sparse optimization features' impact on energy efficiency. Tool available at: https://github.com/NVlabs/timeloop.
Hydrogen-bonding interactions in the series of complexes [M(C4O4)(OH2)2(dmf )2] and [M(C4O4)(OH2)4] (M = Mn, Co, Ni, Cu, Zn) (1998)

Reaction of tetrabutylammonium aminosquarate (1-amino-2-methoxycyclobutenedionate) with MCl2·xH2O (M = Mn, Co) and tetraethylammonium aminosquarate with M(NO3)2·xH2O (M = Ni, Cu, Zn) in N,N-dimethylformamide (dmf) afforded the series of complexes M(C4O4)(OH2)2(dmf)2. The complexes are isomorphous and crystallise in the space group P21/c, with the exception of the copper analogue which crystallises in P21/n. They all have chain structures that are similar to the squarates [M(C4O4)(OH2)4] and the complexes [Zn(C4O4)(OH2)2(dmso)2] and [Ni(C4O4)(C3N2H4)2(OH2)2] and exhibit similar but subtly different hydrogen-bonding interactions to those observed in [Zn(C4O4)(OH2)2(dmso)2]. Analysis of the hydrogen-bonding interactions in these complexes provides an insight into some additional factors that affect these interactions in transition metal squarates and their role in determining tertiary structure. The implications with respect to solid-state materials design are discussed.
Banding Assessment with Controlled Halftoning: The Ten Printer Experiment (2006)

Printer banding which appears as nonuniform light and dark lines across a printed page have been an important image quality issue in the printing industry, and have been studied by many researchers. However, no literature has reported banding perception in different printers with different characteristics of banding. In this paper the authors develop a tool for measuring banding based on human perception. The authors describe new cross-platform experiments using ten different laser printers having different imaging characteristics. In order to focus on the impact of the printer mechanism on banding and to remove the confounding effect of the halftoning algorithm, the authors employ a specially designed line screen with all the test printers. The authors use the pulse width modulation capability of a single reference printer to match the absorptance of these printers, and to also generate extrinsic banding signals. The experimental results identify the points of subjective equality of the ten printers relative to the banding of a reference printer, and provide the basis of a method of computing banding power by considering a contrast sensitivity function. The authors results show that regardless of the different banding spectral characteristics, the contrast banding power of a given printer can be mapped to a perceptually equivalent level of contrast banding power of one reference printer with added extrinsic banding.
SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers (2017)

Mutations in the SMARCA4/BRG1 gene resulting in complete loss of its protein (BRG1) occur frequently in non-small cell lung cancer (NSCLC) cells. Currently, no single therapeutic agent has been identified as synthetically lethal with SMARCA4/BRG1 loss. We identify AURKA activity as essential in NSCLC cells lacking SMARCA4/BRG1. In these cells, RNAi-mediated depletion or chemical inhibition of AURKA induces apoptosis and cell death in vitro and in xenograft mouse models. Disc large homologue-associated protein 5 (HURP/DLGAP5), required for AURKA-dependent, centrosome-independent mitotic spindle assembly is essential for the survival and proliferation of SMARCA4/BRG1 mutant but not of SMARCA4/BRG1 wild-type cells. AURKA inhibitors may provide a therapeutic strategy for biomarker-driven clinical studies to treat the NSCLCs harbouring SMARCA4/BRG1-inactivating mutations.
Photochemistry. 152. Cyclopropanols and the di-.pi.-methane rearrangement: mechanistic and exploratory organic photochemistry (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemistry. 152. Cyclopropanols and the di-.pi.-methane rearrangement: mechanistic and exploratory organic photochemistryHoward E. Zimmerman, John M. Nuss, and Anthony W. TantilloCite this: J. Org. Chem. 1988, 53, 16, 3792–3803Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://pubs.acs.org/doi/10.1021/jo00251a024https://doi.org/10.1021/jo00251a024research-articleACS PublicationsRequest reuse permissionsArticle Views447Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Polarization aberrations induced by graded multilayer coatings in EUV lithography scanners (2016)

The functional form of coating-induced polarization aberrations in EUV lithography systems is evaluated through polarization ray tracing of an example 3&times;EUV scanner with state-of-the-art graded multilayer coatings. In particular, the impact of coating-induced on-axis astigmatism, as well as diattenuation and retardance on image quality are investigated. The point spread function (PSF) consists of four polarization-dependent components: two are nearly diffraction limited and two are highly apodized, and all components can be described by a Mueller matrix Point Spread Matrix (PSM). The highly apodized components are “ghost” images that are larger than the diffraction limit, reducing image contrast and resolution.
Variation in the structure of glucuronoxylomannan in isolates from patients with recurrent cryptococcal meningitis (1995)

Capsular glucuronoxylomannans (GXM) of Cryptococcus neoformans var. neoformans isolates from patients with recurrent cryptococcal meningitis were analyzed by 1H nuclear magnetic resonance spectroscopy and for reactivity with factor sera (Iatron, Tokyo, Japan). For each patient the initial and relapse isolates had previously been shown to be indistinguishable by DNA restriction fragment length polymorphism analysis. For patients J11 and J22 the GXM of the initial and relapse isolates were identical. For patients SB4 and SB6 the GXM of the initial and relapse isolates differed in structure and reactivity with factor sera. In patient SB4 the initial isolate had a serotype A/D structure, and the first relapse isolate had a serotype A structure. The second relapse isolate was a mixture of structures composed of serotype D components, glucuronomannan (GM), and a minor serotype A component. Analysis of the initial isolate from patient SB6 showed a structure composed mainly of serotype D, GM, and minor serotype A components and components not assigned to a particular serotype (N). The relapse isolate had the same composition as the initial isolate except for an increase in the serotype A component. This increase in the serotype A component of the relapse isolate resulted in a change in the serological specificity from serotype D to serotype A/D. The initial isolate from patient J9 had serotype D and GM structures. The first two relapse isolates had serotype D, N, and GM structures and a minor serotype A component. The third relapse isolate had mainly a serotype D structure. All the J9 isolates reacted only with serotype D-specific factor serum. These results indicate that some isolates obtained from patients with recurrent C. neoformans infections have undergone a change in GXM structure during the course of infection. The modification of GXM structure observed in some relapse isolates is reflected in changed serological properties. The results may have important implications for the design of vaccines and antibody-based therapeutic strategies against C. neoformans.
Block polymers from isocyanate‐terminated intermediates. II. Preparation of butadiene–ϵ‐caprolactam and styrene–ϵ‐caprolactam block polymers (1974)

Abstract Polystyrene–nylon 6 and polybutadiene–nylon 6 block copolymers have been prepared from isocyanate‐terminated prepolymers. From extraction and fractionation data the products obtained were found to be mixtures of both homopolymers and pure block copolymer. The polybutadiene–nylon 6 copolymers are extremely pliable at ambient temperatures even at high ϵ‐caprolactam contents (70–80 wt‐%). This is true even though these copolymers show a crystalline melting point at 213°C similar to poly‐ϵ‐caprolactam. Presumably this unusual behavior occurs because of the nature of the synthesis which renders the butadiene portion of these copolymers the continuous phase. Plasticity measurements indicate that pliability is dependent on the molecular weight of the block poly‐ϵ‐caprolactam.
Predictive value of tissue Doppler imaging for left ventricular ejection fraction, remodelling, and infarct size after percutaneous coronary intervention for acute myocardial infarction (2010)

Sm-6 is a significant predictor of post-MI LVEF and infarct size as measured by MRI. In contrast, TDI-derived velocities do not predict LV remodelling.
The Functional Microdomain in Transmembrane Helices 2 and 7 Regulates Expression, Activation, and Coupling Pathways of the Gonadotropin-releasing Hormone Receptor (1999)

Structural microdomains of G protein-coupled receptors (GPCRs) consist of spatially related side chains that mediate discrete functions. The conserved helix 2/helix 7 microdomain was identified because the gonadotropin-releasing hormone (GnRH) receptor appears to have interchanged the Asp 2.50 and Asn 7.49 residues which are conserved in transmembrane helices 2 and 7 of rhodopsin-like GPCRs. We now demonstrate that different side chains of this microdomain contribute specifically to receptor expression, heterotrimeric G protein-, and small G protein-mediated signaling. An Asn residue is required in position 2.50(87) for expression of the GnRH receptor at the cell surface, most likely through an interaction with the conserved Asn 1.50(53) residue, which we also find is required for receptor expression. Most GPCRs require an Asp side chain at either the helix 2 or helix 7 locus of the microdomain for coupling to heterotrimeric G proteins, but the GnRH receptor has transferred the requirement for an acidic residue from helix 2 to 7. However, the presence of Asp at the helix 7 locus precludes small G protein-dependent coupling to phospholipase D. These results implicate specific components of the helix 2/helix 7 microdomain in receptor expression and in determining the ability of the receptor to adopt distinct activated conformations that are optimal for interaction with heterotrimeric and small G proteins.
An International Ki67 Reproducibility Study (2013)

Substantial variability in Ki67 scoring was observed among some of the world's most experienced laboratories. Ki67 values and cutoffs for clinical decision-making cannot be transferred between laboratories without standardizing scoring methodology because analytical validity is limited.
Submicrometer In-Plane Integrated Surface Plasmon Cavities (2007)

The optical properties of in-plane integrated surface plasmon polariton (SPP) cavities comprised of a thin film area sandwiched between two one-dimensional Bragg SPP mirrors are investigated numerically and experimentally. We discuss the resonance condition of these cavities, and we analyze in details the physical origin of the dispersion of this resonance. On the basis of numerical results, we show that in-plane SPP cavities can be used to achieve local SPP field enhancement and antireflecting SPP layers. The numerical results are compared to near-field optical images recorded by operating a photon scanning tunneling microscope. From the near-field images recorded over cavities with different sizes at different frequencies, we verify the resonance condition obtained numerically and we measure the quality factor of a submicrometer in-plane integrated SPP cavity.
Shaping Spectrum of Short-time Fourier Transform for Broadening the Seismic Bandwidth (2016)

Summary Increasing seismic resolution is important for detecting more structural and stratigraphic detail. We propose a novel algorithm that combines the benefits of both the Fourier scaling theorem (FST) and the short-time Fourier transform (STFT) to obtain broader frequency bandwidth and thus improve the seismic resolution. In the proposed algorithm, the frequency spectrum in each window of the STFT is substituted by a weighted-stacking amplitude spectrum through the FST. We test the performance of the algorithm on synthetic and real data to obtain broader frequency spectrum without greatly boosting noise.
Kinetics of nucleosome unfolding at low ionic strength (1981)

Abstract The kinetics of a conformational change which occurs in nucleosome core particles at about 1 m M ionic strength have been studied by observing changes in the fluorescence of labeled histone H3. The unfolding reaction is intramolecular since no concentration dependence is observed. However, the kinetics are unexpectedly complicated and reveal evidence of at least three relaxation times. It is possible to fit the kinetics observed under several conditions to a consistent four‐state cyclic mechanism in which folded and unfolded forms can inter‐convert by two parallel pathways, each involving a distinct intermediate. While the data are not sufficient to establish this mechanism as a unique choice, they exclude many simpler possibilities. The cyclic mechanism is quite reasonable in view of what is currently known about the structures of the folded and unfolded forms.
ChemInform Abstract: SOLVATED NICKEL ATOMS AND NICKEL SLURRIES: NICKEL ATOM‐TOLUENE MICROSOLUTION AND MATRIX OPTICAL SPECTROSCOPY (1982)

Abstract Zur Erörterung der Natur der solvatisierten Nickelatome vom Klabunde‐Typ und ihrer Anwendung für Clusterkatalysatorsysteme wird mit Hilfe der Titeltechniken‐die Wechselwirkung zwischen Nickelatomen und Toluol im Temp.‐Bereich 12‐290 K untersucht.‐ Die in der Klabunde‐Terminologie der Stufe Ientsprechenden "solvatisierten" Nickelatome entsprechen einem thermisch sehr labilen Bis‐[toluol]‐nickelkomplex, der in Argon und Methylcyclohexan im Bereich 12 bis 77 Kexistiert.