gebhart/patrepeval huggingface dataset:
Synergistic antitumor effect of combined use of adenoviral-mediatedp53gene transfer and antisense oligodeoxynucleotide targetingclusteringene in an androgen-independent human prostate cancer model (2005)

Our recent studies showed that antisense oligodeoxynucleotide targeting antiapoptotic gene, clusterin, enhanced apoptosis induced by conventional therapeutic modalities using several prostate cancer models. In this study, to establish a more effective therapeutic strategy against prostate cancer, we investigated the effect of combined treatment with antisense clusterin oligodeoxynucleotide and adenoviral-mediated p53 gene transfer (Ad5CMV-p53) in an androgen-independent human prostate PC3 tumor model. Treatment of PC3 cells with 500 nmol/L antisense clusterin oligodeoxynucleotide decreased clusterin mRNA by >80% compared with that with 500 nmol/L mismatch control oligodeoxynucleotide. Clusterin mRNA expression in PC3 cells was highly up-regulated by Ad5CMV-p53 treatment; however, antisense clusterin oligodeoxynucleotide treatment further suppressed clusterin expression in PC3 cells after Ad5CMV-p53 treatment. Antisense clusterin oligodeoxynucleotide treatment significantly enhanced the sensitivity of Ad5CMV-p53 in a dose-dependent manner, reducing the IC50 of Ad5CMV-p53 by 75%. Apoptotic cell death was detected after combined treatment but not after treatment with either agent alone. In vivo administration of antisense clusterin oligodeoxynucleotide and Ad5CMV-p53 resulted in a significant inhibition of s.c. PC3 tumor growth as well as lymph node metastases from orthotopic PC3 tumors compared with administration of either agent alone. Furthermore, combined treatment with antisense clusterin oligodeoxynucleotide, Ad5CMV-p53, and mitoxantrone completely eradicated s.c. PC3 tumors and lymph node metastases from orthotopic PC3 tumors in 60% and 100% of mice, respectively. These findings suggest that combined treatment with antisense clusterin oligodeoxynucleotide and Ad5CMV-p53 could be a novel strategy to inhibit progression of hormone-refractory prostate cancer and that further addition of chemotherapeutic agents may help to enhance the efficacy of this combined regimen.
248: Effect of ß-Nicotinamide Adenine Dinucleotide (ß-NAD) On in vivo Bladder Function in Mice (2007)

You have accessJournal of UrologyModerated Poster 9, Sunday, May 20, 2007, 10:00 am - 12:00 pm1 Apr 2007248: Effect of ß-Nicotinamide Adenine Dinucleotide (ß-NAD) On in vivo Bladder Function in Mice Shiro Hiragata, Michael B. Chancellor, William C. de Groat, Violeta N. Mutafova-Yambolieva, and Naoki Yoshimura Shiro HiragataShiro Hiragata More articles by this author , Michael B. ChancellorMichael B. Chancellor More articles by this author , William C. de GroatWilliam C. de Groat More articles by this author , Violeta N. Mutafova-YambolievaVioleta N. Mutafova-Yambolieva More articles by this author , and Naoki YoshimuraNaoki Yoshimura More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)30513-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "248: Effect of ß-Nicotinamide Adenine Dinucleotide (ß-NAD) On in vivo Bladder Function in Mice." The Journal of Urology, 177(4S), p. 83 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 83 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Shiro Hiragata More articles by this author Michael B. Chancellor More articles by this author William C. de Groat More articles by this author Violeta N. Mutafova-Yambolieva More articles by this author Naoki Yoshimura More articles by this author Expand All Advertisement PDF downloadLoading ...
Formulation of PID Control for DC–DC Converters Based on Capacitor Current: A Geometric Context (2011)

The output voltage derivative term associated with a PID controller injects significant noise in a dc-dc converter. This is mainly due to the parasitic resistance and inductance of the output capacitor. Particularly, during a large-signal transient, noise injection significantly degrades phase margin. Although noise characteristics can be improved by reducing the cutoff frequency of the low-pass filter associated with the voltage derivative, this degrades the closed-loop bandwidth. A formulation of a PID controller is introduced to replace the output voltage derivative with information about the capacitor current, thus reducing noise injection. It is shown that this formulation preserves the fundamental principle of a PID controller and incorporates a load current feedforward, as well as inductor current dynamics. This can be helpful to further improve bandwidth and phase margin. The proposed method is shown to be equivalent to a voltage-mode-controlled buck converter and a current-mode-controlled boost converter with a PID controller in the voltage feedback loop. A buck converter prototype is tested, and the proposed algorithm is implemented using a field-programmable gate array.
Hepatic binding and internalization of low density lipoprotein-gold conjugates in rats treated with 17 alpha-ethinylestradiol. (1981)

Receptor-mediated hepatic uptake of low density lipoproteins (LDL) conjugated to colloidal gold was studied by perfusion of livers from rats treated for 5 d with 17 alpha-ethinylestradiol. Estrogen treatment resulted in a marked decrease in serum lipid and lipoprotein concentrations. After 15 min of perfusion the conjugate was bound to the hepatic microvilli of both control and estrogen-treated rats; the estrogen-treated rats showed an 8- to 11-fold greater number of membrane-bound conjugates. The conjugates were bound to the membrane receptor by the LDL particle because the gold granules were regularly displaced from the membrane by 20 +/- 3.2 nm, the diameter of LDL. Internalization of the conjugate, evident by gold particles in multivesicular bodies, occurred at coated pits at the base of the microvillus where coated vesicles containing a single gold-LDL conjugate were released. After 1 h of perfusion, the livers from the estrogen-treated rats showed all phases of endocytosis and incorporation into multivesicular bodies of the conjugate. After 2 h of perfusion, there was congregation of gold-labeled lysosomes near the bile canaliculi. Gold-LDL conjugates were also observed to bind and be internalized by Kupffer cells and sinusoidal endothelium. These findings indicate that estrogen treatment induces hepatic receptors for LDL. The catabolic pathway of binding and endocytosis of the conjugate is similar to that seen in fibroblasts, although slower. Because gold-LDL conjugates were also present in the Kupffer and endothelial cells, the uptake of LDL by the liver involves the participation of more than a single cell type.
Interpolator for infrared images (1994)

The use of focal plane arrays in IR imaging systems is becoming increasingly important, but in the long-wave IR region the number of detector elements in the array is limited by the current state of technology, and this in turn restricts the available spatial resolution or field of view. An image processing scheme is described that is able to interpolate and enhance an image in a unified moving window operation. The image is first expanded to the required size by pixel replication and then processed so that the resulting spectrum approximates that of the original scene. A numerical method has been developed to calculate the interpolator and its use has been demonstrated in a computer simulation.
Supramolecular Chemistry in Biological ImagingIn Vivo (2012)

Abstract Biological imaging techniques, including magnetic resonance, optical, nuclear, and ultrasound, can be valuable tools for noninvasively studying biochemical processes at the molecular level. This branch of imaging is referred to as molecular imaging. A main challenge in the field of in vivo molecular imaging is that existing probes limit clinical applications because of their inadequate sensitivity, specificity, and targeting efficiency. Supramolecular chemistry may provide a viable solution to some of these issues. Supramolecular chemical processes involve molecular components assembled into a single, large entity via noncovalent intermolecular forces. The supramolecular concepts of host–guest interaction and self‐assembly have been widely used in the development of more specialized imaging probes for in vivo imaging. This chapter discusses how supramolecular chemistry has been used to design contrast agents with improved signal amplification and specificity for each of the different imaging modalities. Particular attention is focused on magnetic resonance imaging (MRI). Multimodal probes that have benefited from supramolecular chemistry are discussed.
SiGe:C profile optimization for low noise performance (2011)

Today's state-of-the-art SiGe BiCMOS processes show impressive high-frequency performance, with ƒ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</inf> and ƒ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">MAX</inf> exceeding 500GHz. However, SiGe can also offer significant performance gain at more moderate application frequencies. In this paper we discuss the optimization of SiGe heterojunction bipolar transistors (HBTs) for very low noise applications in the 2–10GHz range. By careful tuning of the base-profile, minimum noise figures below 0.55dB and 0.35dB are obtained at 10GHz and 2GHz respectively.
A risk analysis spreadsheet for both time‐lapse VSP and 4D seismic reservoir monitoring (2000)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2000A risk analysis spreadsheet for both time‐lapse VSP and 4D seismic reservoir monitoringAuthors: David E. LumleySteve ColeMark A. MeadowsAli TuraBill HottmanBruce CornishMike CurtisNicida MaerefatDavid E. Lumley4th Wave Imaging, Steve Cole4th Wave Imaging, Mark A. Meadows4th Wave Imaging, Ali Tura4th Wave Imaging, Bill HottmanHalliburton Energy Services, Bruce CornishHalliburton Energy Services, Mike CurtisHalliburton Energy Services, and Nicida MaerefatHalliburton Energy Serviceshttps://doi.org/10.1190/1.1815732 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1815732FiguresReferencesRelatedDetailsCited ByThe combined effects of pressure and cementation on 4D seismic dataMatthew Saul and David Lumley11 March 2015 | GEOPHYSICS, Vol. 80, No. 2Time‐lapse VSP field test for gas reservoir monitoring using permanent fiber optic seismic systemJacques Blanco, Geomec Sverre Knudsen, and F. X. (Tad) Bostick III6 October 2006 SEG Technical Program Expanded Abstracts 2000ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2000 Pages: 2484 publication data© 2000 Copyright © 2000 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 04 Jan 2005 CITATION INFORMATION David E. Lumley, Steve Cole, Mark A. Meadows, Ali Tura, Bill Hottman, Bruce Cornish, Mike Curtis, and Nicida Maerefat, (2000), "A risk analysis spreadsheet for both time‐lapse VSP and 4D seismic reservoir monitoring," SEG Technical Program Expanded Abstracts : 1647-1650. https://doi.org/10.1190/1.1815732 Plain-Language Summary PDF DownloadLoading ...
Algorithm design for real-time audio signal processing (2005)

There is a fundamental conflict between algorithms which must operate in real time and algorithms which may operate out of real time. For real time operation, the compute time must be approximately constant for each sample, and the overall delay introduced by the computation must be small. We present an implementation of linear prediction coefficient calculation and fast Fourier transform computation which are "unrolled" so that a small and constant portion of the calculation is done on each sample.
4D tumor centroid tracking using orthogonal 2D dynamic MRI: Implications for radiotherapy planning (2013)

The authors have established viability of a novel and practical pretreatment, 4D tumor centroid tracking method employing a commercially available dynamic MRI sequence. Further developments from the vendor are likely needed to provide a reliably synchronized surrogate 1D respiratory signal, which will likely broaden the utility of this method in the pretreatment radiotherapy planning context.
Cloning and expression of guinea pig TIMP-2. Expression in normal and hyperoxic lung injury (2000)

Tissue inhibitors of metalloproteinases (TIMPs) play a key regulatory role in extracellular matrix remodeling. By screening a lung library with a human TIMP-2 cDNA probe, we have isolated the cDNA corresponding to guinea pig TIMP-2. The 3.5-kb cDNA presents an open reading frame that predicts a protein of 220 amino acids showing 97.2, 96.8, 97.2, and 77.3% overall identity with human, mouse, rat, and chicken TIMP-2, respectively. Guinea pig TIMP-2 cDNA was expressed in CHO-K1 cells, showing a protein with the expected molecular weight and activity. Northern blot analysis revealed TIMP-2 expression in brain, kidney, intestine, spleen, heart, and lung. Transforming growth factor-beta downregulated TIMP-2 mRNA in guinea pig lung fibroblasts, whereas a variety of other stimuli showed no effect. In normal and hyperoxia-exposed lungs, TIMP-2 mRNA was mainly localized in alveolar macrophages and epithelial cells. No quantitative differences were found by Northern blot. These results confirm that TIMP-2 is highly conserved in mammals and largely expressed in lungs.
Performance Analysis of a Multicast Protocol for Wireless Environments (2000)

This paper presents a performance study, using both analytical modeling and simulation techniques, of a new end-to-end reliable multicast protocol for use in environments with wireless access. The proposed pro tocol, called the reliable mobile multicast protocol (RM2), divides a multicast tree into sub-trees where subcasting is applied within the relatively smaller regions using a hierarchical tree of retransmission servers (RSs). RM2 is receiver-oriented in that the transmitter does not need to know its receivers, hence offering better scalability. The Internet Group Management Protocol is used to manage group membership whereas the IETF's Mobile IP offers support to user mobility through a temporary IP address. Each RS has a retransmission subcast ad dress shared by its members which may be dynamically configured using allocation schemes such as the IETF's MADCAP. More important, RM2 uses a dynamic re transmission strategy to switch between multicast and unicast retransmission modes according to the amount of extra load generated in the network and in the wire less interfaces by packet retransmissions. It is shown through analytical modeling and simulation that RM2's dynamic adaptation is not only important but also necessary when considering mobile wireless access.
A Seismic Evaluation Method of Medium-High Rise Steel Reinforced Concrete Buildings for Preventing Story Collapse (2012)

本論文は、中高層SRC造集合住宅の桁行方向の第２次診断法に基づく建物高さ方向の耐震性能の分布を分析し、強度が低い弱点層に損傷が集中する可能性を示す。特定層への損傷集中に影響する要因として、柱梁耐力比、高さ方向の鉛直部材の強度分布を取り上げ損傷集中との関係を検討する。その結果を踏まえ、中高層SRC造建築物において、特定層への大破あるいは中破以上の大きな被害集中を回避することを目的とし、実務的に使いやすい第２次診断法に柱梁耐力比と高さ方向の鉛直部材の強度分布（第２次診断法のCTU·SDの分布）を考慮した耐震診断法（第２、３次診断法）の選定について提案する。
Momentum angular mapping of enhanced Raman scattering of single-walled carbon nanotube (2017)

We perform momentum mapping of the Raman scattering of individual single-walled carbon nanotubes (SWNTs) or thin ropes of SWNTs enhanced by surface plasmons sustained by either a linear chain of nanoantennas or flower-shaped nanoparticles. The momentum spectroscopy of Raman scattering of the carbon nanotube (CNT) demonstrates the direct verification of momentum selection rules and identifies the characteristic bands of the molecules or the nanomaterials under scrutiny. The characteristic vibrational signatures of the D, G−, and G bands provide an isotropic response in k-space irrespective of the arrangement of the enhancing platform. However, other dispersive or double resonance bands, such as D−, D+, D′, M, and iTOLA bands appear as a dipolar emission oriented towards the long axis of the CNT regardless of the CNT orientation but strongly depend on the patterning of enhancement of the electromagnetic field.
Interleukin‐37 improves T‐cell‐mediated immunity and chimeric antigen receptor T‐cell therapy in aged backgrounds (2021)

Aging-associated declines in innate and adaptive immune responses are well documented and pose a risk for the growing aging population, which is predicted to comprise greater than 40 percent of the world's population by 2050. Efforts have been made to improve immunity in aged populations; however, safe and effective protocols to accomplish this goal have not been universally established. Aging-associated chronic inflammation is postulated to compromise immunity in aged mice and humans. Interleukin-37 (IL-37) is a potent anti-inflammatory cytokine, and we present data demonstrating that IL-37 gene expression levels in human monocytes significantly decline with age. Furthermore, we demonstrate that transgenic expression of interleukin-37 (IL-37) in aged mice reduces or prevents aging-associated chronic inflammation, splenomegaly, and accumulation of myeloid cells (macrophages and dendritic cells) in the bone marrow and spleen. Additionally, we show that IL-37 expression decreases the surface expression of programmed cell death protein 1 (PD-1) and augments cytokine production from aged T-cells. Improved T-cell function coincided with a youthful restoration of Pdcd1, Lat, and Stat4 gene expression levels in CD4<sup>+</sup> T-cells and Lat in CD8<sup>+</sup> T-cells when aged mice were treated with recombinant IL-37 (rIL-37) but not control immunoglobin (Control Ig). Importantly, IL-37-mediated rejuvenation of aged endogenous T-cells was also observed in aged chimeric antigen receptor (CAR) T-cells, where improved function significantly extended the survival of mice transplanted with leukemia cells. Collectively, these data demonstrate the potency of IL-37 in boosting the function of aged T-cells and highlight its therapeutic potential to overcome aging-associated immunosenescence.
Quantitative imaging of the collective cell movements shaping an embryo (2008)

The recent development of imaging and image processing techniques, such as 4D microscopy and 3D cell tracking, enables analysis through quantification of the movement of large cell populations <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in</i> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">vivo</i> . These imaging approaches provide an opportunity to study embryonic morphogenesis during development from the level of cellular processes to the scale of entire organism. Image analysis reveals cell collective behaviors that shape an embryo and offers some surprising insights into the cell-cell interactions involved in concerted movements. We illustrate the power of this approach by studying the early development of Drosophila embryos.
Cross-lingual Linking of Multi-word Entities and their corresponding Acronyms (2016)

This paper reports on an approach and experiments to automatically build a cross-lingual multi-word entity resource. Starting from a collection of millions of acronym/expansion pairs for 22 languages where expansion variants were grouped into monolingual clusters, we experiment with several aggregation strategies to link these clusters across languages. Aggregation strategies make use of string similarity distances and translation probabilities and they are based on vector space and graph representations. The accuracy of the approach is evaluated against Wikipedia's redirection and cross-lingual linking tables. The resulting multi-word entity resource contains 64,000 multi-word entities with unique identifiers and their 600,000 multilingual lexical variants. We intend to make this new resource publicly available.
Collision warning with auto brake (2006)

Godkänd; 2006; Bibliografisk uppgift: CD-ROM; 20061228 (ysko)
The E. coli sirtuin CobB shows no preference for enzymatic and nonenzymatic lysine acetylation substrate sites (2014)

N(ε) -lysine acetylation is an abundant posttranslational modification of thousands of proteins involved in diverse cellular processes. In the model bacterium Escherichia coli, the ε-amino group of a lysine residue can be acetylated either catalytically by acetyl-coenzyme A (acCoA) and lysine acetyltransferases, or nonenzymatically by acetyl phosphate (acP). It is well known that catalytic acCoA-dependent N(ε) -lysine acetylation can be reversed by deacetylases. Here, we provide genetic, mass spectrometric, structural and immunological evidence that CobB, a deacetylase of the sirtuin family of NAD(+) -dependent deacetylases, can reverse acetylation regardless of acetyl donor or acetylation mechanism. We analyzed 69 lysines on 51 proteins that we had previously detected as robustly, reproducibly, and significantly more acetylated in a cobB mutant than in its wild-type parent. Functional and pathway enrichment analyses supported the hypothesis that CobB regulates protein function in diverse and often essential cellular processes, most notably translation. Combined mass spectrometry, bioinformatics, and protein structural data provided evidence that the accessibility and three-dimensional microenvironment of the target acetyllysine help determine CobB specificity. Finally, we provide evidence that CobB is the predominate deacetylase in E. coli.
On Sum Rate of Multi-User Distributed Antenna System with Circular Antenna Layout (2007)

In this paper, we investigate the uplink of a power- controlled multi-user distributed antenna system (DAS) with antennas deployed on a circle. Applying results from random matrix theory, we prove that the per-user sum rate and the total transmit power both converge as user number and antenna number go to infinity with a constant ratio. The relationship between the asymptotic per-user sum rate and the asymptotic total transmit power is established. We then deal with a typical path loss exponent of 4, present the rate-power relationship in a closed form and find the optimal circle radius for antenna deployment. Simulation results are also provided to demonstrate the validity of our analysis.
Over-the-Air Time Synchronization for URLLC: Requirements, Challenges and Possible Enablers (2018)

Ultra-reliable and low-latency communications (URLLC) is an emerging feature in 5G and beyond wireless systems, which is introduced to support stringent latency and reliability requirements of mission-critical industrial applications. In many potential applications, multiple sensors/actuators collaborate and require isochronous operation with strict and bounded jitter, e.g., \SI{1}{\micro\second}. To this end, network time synchronization becomes crucial for real-time and isochronous communication between a controller and the sensors/actuators. In this paper, we look at different applications in factory automation and smart grids to reveal the requirements of device-level time synchronization and the challenges in extending the high-granularity timing information to the devices. Also, we identify the potential over-the-air synchronization mechanisms in 5G radio interface, and discuss the needed enhancements to meet the jitter constraints of time-sensitive URLLC applications.
A High-Level Synthesis Case Study on Light Propagation Simulation in Turbid Media (2018)

In this work, we look into the benefit of using High-Level Synthesis (HLS) in building and accelerating complex systems with floating-point operations. We present a highly-optimized Monte-Carlo (MC) simulator for light propagation in 3D voxel-based biological tissue representations using HLS. We show how to utilize HLS in creating efficient structures that help achieve the desired throughput. We use Vivado to implement the design on a Xilinx Kintex Ultrascale FPGA running at 150 MHz. With a design time of 1.5 months, experimental results show a 3x speedup against the fastest software simulator published to date.