gebhart/patrepeval huggingface dataset:
Do It Yourself Hyperspectral Imaging with Everyday Digital Cameras (2016)

Capturing hyperspectral images requires expensive and specialized hardware that is not readily accessible to most users. Digital cameras, on the other hand, are significantly cheaper in comparison and can be easily purchased and used. In this paper, we present a framework for reconstructing hyperspectral images by using multiple consumer-level digital cameras. Our approach works by exploiting the different spectral sensitivities of different camera sensors. In particular, due to the differences in spectral sensitivities of the cameras, different cameras yield different RGB measurements for the same spectral signal. We introduce an algorithm that is able to combine and convert these different RGB measurements into a single hyperspectral image for both indoor and outdoor scenes. This camera-based approach allows hyperspectral imaging at a fraction of the cost of most existing hyperspectral hardware. We validate the accuracy of our reconstruction against ground truth hyperspectral images (using both synthetic and real cases) and show its usage on relighting applications.
High-Voltage IGBT turn-off at transition from overcurrent to desaturation (2021)

The turn-off capability of a power semiconductor is normally given by the datasheet with test conditions. &#13;\nThe RBSOA (Reverse Bias Safe Operation Area) diagram limits the collector-emitter peak voltage and &#13;\nmaximum turn-off current [1]. As mentioned in the early literature and many datasheets of IGBT power &#13;\nmodules, the current which can be turned off is limited to twice the nominal current, in the between this &#13;\nand short circuit it is forbidden to turn off the device [2]. In this paper, the turn-off behaviour of HV-&#13;\nIGBTs at the transition from overcurrent to desaturation is investigated with a 2D half-cell model in &#13;\nSynopsys TCAD as well as with single chip measurements. This article focuses on the classification of the &#13;\nturn-off process near the VCE desaturation, with respect to the plasma- and electric field distribution, &#13;\ndynamic avalanche, as well as electric field peaks which occur during this process. It shows that the IGBT &#13;\ncan be operated in this former forbidden region successfully, and a beginning desaturation releases &#13;\ndynamic avalanche.
Broadband and compact silicon mode converter designed using a wavefront matching method (2020)

A broadband and compact TE0-TE1 mode converter for a mode division multiplexing system designed using a wavefront matching method is realized. We present the first experimental demonstration of a silicon waveguide device designed by a wavefront matching method. In order to achieve broadband operation of the silicon mode converter, seven wavelengths are considered in its optimization process. The designed silicon mode converter is fabricated via a standard complementary metal-oxide-semiconductor technology, which enables low-cost mass production. Measurements performed using the fabricated mode converter correlate strongly with the calculated results.
Intermolecular Interaction and a Concentration-Quenching Mechanism of Phosphorescent Ir(III) Complexes in a Solid Film (2006)

Solid-state self-quenching processes of highly efficient Ir(III) phosphorescent emitters are investigated by the measurement of thin film photoluminescence quantum efficiency and transient lifetime as a function of doping concentration in a host matrix. The radiative decay rate constant is found to be independent from the average distance between dopant molecules (R), and the concentration-quenching rate constant is shown to be dependent on R(-6). The quenching dependence on R strongly suggests that luminescent concentration quenching in a phosphorescent Ir(III) complex:host film is controlled by dipole-dipole deactivating interactions as described by the Förster energy transfer model.
Secreted extracellular domains of macrophage scavenger receptors form elongated trimers which specifically bind crocidolite asbestos. (1993)

Macrophage scavenger receptors, which have been implicated in the development of atherosclerosis and other macrophage-mediated events, are trimeric integral membrane glycoproteins whose extracellular domains have been predicted to include alpha-helical coiled-coil, collagenous and globular structures. To elucidate further the structural and functional properties of these receptors, we generated transfected Chinese hamster ovary cells which express secreted extracellular domains of the type I and type II bovine scavenger receptors and developed a solid-phase bead-binding assay to assess their ligand-binding properties. The secreted receptors exhibited the distinctive high-affinity, broad polyanionic ligand-binding specificity and the pH dependence of binding which characterize the membrane-anchored cell-surface forms of the receptors. Both the type I and type II secreted receptors were trimeric glycoproteins comprising disulfide-linked dimers and noncovalently associated monomers. Gel filtration and glycerol-gradient centrifugation established that the type II trimers were highly elongated and did not associate into higher order oligomers at the low concentrations used in these experiments. Crocilodite asbestos, which is phagocytosed by alveolar macrophages and can cause asbestosis and mesothelioma, bound efficiently to secreted type I receptors and less well to the type II receptors. This binding was specific in that it was competed by a variety of well established scavenger receptor ligands but not by negative controls. These studies have identified a new type of insoluble scavenger receptor ligand, and have raised the possibility that scavenger receptors may play a role in mediating the physiological and pathological interactions of inspired particles with alveolar macrophages.
6F-4 50-kHz Capacitive Micromachined Ultrasonic Transducers for Generating Highly Directional Sound with Parametric Arrays (2007)

Capacitive micromachined ultrasonic transducers (CMUTs) were designed, fabricated, and characterized to generate highly directional sound in air with parametric arrays. Finite element modelling was used to design the vacuum-sealed CMUTs to operate at frequencies of approximately 50 kHz and to generate pressures of approximately 139 dB (0 dB = 20 muPa RMS) at the face of the transducer. CMUTs with 40-mum and 60-mum thick membranes were fabricated and characterized. The characterized devices had center frequencies of 46 kHz and 55 kHz and bandwidths of 2.0 kHz and 5.4 kHz, respectively. Driven with a 200-V peak-to-peak excitation voltage, the devices generated up to 115 dB and 107 dB of pressure at 3 m, respectively. The devices were used to produce a narrow (8.7deg) beam of 5 kHz sound, which at 3 m was 58 dB.
Heat Waves Alter Carbon Allocation and Increase Mortality of Aleppo Pine Under Dry Conditions (2018)

Climate extremes are likely to occur more frequently in the future, including a combination of heat waves and drought. However, the responses of trees to combined stress and their post-stress recovery are not fully understood yet. Therefore, this study investigates the responses of semi-arid Pinus halepensis seedlings to moderate drought, heat and combined heat-drought stress, as well as post-stress recovery. The seedlings were grown under controlled conditions and exposed to two 4-day-long heat periods, reaching air temperature maxima of 42 °C and vapor pressure deficit (VPD) of 7 kPa. Day- and nighttime canopy gas exchange was measured and differences in shoot and root allocation of non-structural carbohydrate (NSC) compounds (soluble sugars, starch, cyclitols and carboxylic acids) assessed. Fluorescence parameters, nitrate levels, proline content and shoot water potential (ψ) provided additional indicators for stress severity and recovery performance. During the heat periods, net photosynthesis and stomatal conductance decrease immediately. This decline was modest under well-watered conditions, with transpiration and dark respiration rates remaining high and despite reductions in root NSC content, trees recovered following heat release. This was not the case in the heat-drought treatment, where stress resulted in mortality was high and the few surviving seedlings showed reduced gas exchange rates and low root NSC content, while leaf nitrate and proline remained elevated even three weeks after heat release. Shoot ψ indicated that hydraulic failure was not the reason for mortality in the heat-drought exposed seedlings. Instead, we hypothesize that low transpiration rates, which resulted in needle temperatures >47 °C during heat stress (6 °C above air temperature) have led to irreversible damage. In summary, it could be demonstrated that heat waves in combination with moderate drought can either result in increased mortality or, if the seedlings survive, in delayed recovery. This highlights the potential of an increase in heat wave temperatures to trigger forest decline in semi-arid regions.
Near zero laser speckle liquid crystal device (2020)

Laser-based displays suffer from speckle noise due to the random inference patterns of scattered coherent light from rough surfaces. Commonly utilized solution, such as moving diffusers, creates time-varying speckle patterns that were averaged on the observer’s retina or the image sensor. This solution requires the use of motorized parts and can be bulky with the potential risk of mechanical failure. We present a liquid crystal device that reduces speckle noise by over 90%. It is electrically driven, compact, and with no motorized parts. The randomized, time-varying domains with mismatched refractive indices of the liquid crystals produce varying speckle patterns. A near zero speckle contrast is achieved.
Very compact thin power amplifier module for gigahertz-bandcellular systems (1998)

A power amplifier module for gigahertz-band cellular phone systems, developed using a build-up structure based on MCM-D technology and all planar passive circuit components, is investigated. It is shown that the very compact thin module can be incorporated with a thickness of &lt; 1 mm and a volume of &lt; 0.1 cc.
A Novel Method for the Culture and Polarized Stimulation of Human Intestinal Mucosa Explants (2013)

Few models currently exist to realistically simulate the complex human intestine's micro-environment, where a variety of interactions take place. Proper homeostasis directly depends on these interactions, as they shape an entire immunological response inducing tolerance against food antigens while at the same time mounting effective immune responses against pathogenic microbes accidentally ingested with food. Intestinal homeostasis is preserved also through various complex interactions between the microbiota (including food-associated beneficial bacterial strains) and the host, that regulate the attachment/degradation of mucus, the production of antimicrobial peptides by the epithelial barrier, and the "education" of epithelial cells' that controls the tolerogenic or immunogenic phenotype of unique, gut-resident lymphoid cells' populations. These interactions have been so far very difficult to reproduce with in vitro assays using either cultured cell lines or peripheral blood mononuclear cells. In addition, mouse models differ substantially in components of the intestinal mucosa (mucus layer organization, commensal bacteria community) with respect to the human gut. Thus, studies of a variety of treatments to be brought in the clinics for important stress-related or pathological conditions such as irritable bowel syndrome, inflammatory bowel disease or colorectal cancer have been difficult to carry out. To address these issues, we developed a novel system that enables us to stimulate explants of human intestinal mucosa that retain their in situ conditioning by the host microbiota and immune response, in a polarized fashion. Polarized apical stimulation is of great importance for the outcome of the elicited immune response. It has been repeatedly shown that the same stimuli can produce completely different responses when they bypass the apical face of the intestinal epithelium, stimulating epithelial cells basolaterally or coming into direct contact with lamina propria components, switching the phenotype from tolerogenic to immunogenic and causing unnecessary and excessive inflammation in the area. We achieved polarized stimulation by gluing a cave cylinder which delimited the area of stimulation on the apical face of the mucosa as will be described in the protocol. We used this model to examine, among others, differential effects of three different Lactobacilli strains. We show that this model system is very powerful to assess the immunomodulatory properties of probiotics in healthy and disease conditions.
Relationships between in vitro drug dissolution and in vivo response (2012)

In recent years there has been an effort to relate manufacturing variables to the performance of the dosage form from a clinical point of view (in terms of safety and efficacy). Consequently any control strategy or the establishment of meaningful specifications should take into consideration the clinical impact on the patient. Since plasma levels are considered to be one of the most useful surrogates for clinical safety (in that bioequivalent plasma levels are considered therapeutically equivalent) and dissolution is the best surrogate for bioavailability, it is a natural consequence that dissolution be used to establish the design space in which all the formulations would have similar safety and efficacy profiles.
ChemInform Abstract: A Functional Screening of Adenosine Analogues at the Adenosine A2B Receptor: A Search for Potent Agonists. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle (2016)

AMP-activated protein kinase (AMPK) plays diverse roles and coordinates complex metabolic pathways for maintenance of energy homeostasis. This could be explained by the fact that AMPK exists as multiple heterotrimer complexes comprising a catalytic α-subunit (α1 and α2) and regulatory β (β1 and β2)- and γ (γ1, γ2, γ3)-subunits, which are uniquely distributed across different cell types. There has been keen interest in developing specific and isoform-selective AMPK-activating drugs for therapeutic use and also as research tools. Moreover, establishing ways of enhancing cellular AMPK activity would be beneficial for both purposes. Here, we investigated if a recently described potent AMPK activator called 991, in combination with the commonly used activator 5-aminoimidazole-4-carboxamide riboside or contraction, further enhances AMPK activity and glucose transport in mouse skeletal muscle ex vivo. Given that the γ3-subunit is exclusively expressed in skeletal muscle and has been implicated in contraction-induced glucose transport, we measured the activity of AMPKγ3 as well as ubiquitously expressed γ1-containing complexes. We initially validated the specificity of the antibodies for the assessment of isoform-specific AMPK activity using AMPK-deficient mouse models. We observed that a low dose of 991 (5 μM) stimulated a modest or negligible activity of both γ1- and γ3-containing AMPK complexes. Strikingly, dual treatment with 991 and 5-aminoimidazole-4-carboxamide riboside or 991 and contraction profoundly enhanced AMPKγ1/γ3 complex activation and glucose transport compared with any of the single treatments. The study demonstrates the utility of a dual activator approach to achieve a greater activation of AMPK and downstream physiological responses in various cell types, including skeletal muscle.
Novel Mechanisms of Valsartan on the Treatment of Acute Myocardial Infarction Through Inhibition of the Antiadhesion Molecule Periostin (2007)

Our previous study demonstrated that periostin, an extracellular matrix protein, plays an important role in left ventricular remodeling through the inhibition of cell-cell interactions. Because the gene regulation of periostin has not yet been examined, we focused on the effects of angiotensin (Ang) II and mechanical stretch, because Ang II and mechanical stretch are related to cardiac remodeling after myocardial infarction. First, we examined the effects of Ang II on periostin in myocytes and fibroblasts in vitro. Ang II significantly increased periostin through phosphatidylinositol 3-kinase, c-Jun N-terminal kinase, p38, and extracellular signal-regulated kinase 1/2 pathways in myocytes and fibroblasts (P<0.05). On the other hand, mechanical stretch also significantly increased periostin expression (P<0.05). This increase was inhibited partially, but significantly, by an Ang II receptor blocker, valsartan, and inhibited almost completely by valsartan with the neutralization antibodies for transforming growth factor-beta and platelet-derived growth factor-BB (P<0.05). Therefore, we further examined periostin expression in vivo. Periostin expression was significantly increased in infarcted myocardium (P<0.05), and treatment with valsartan significantly attenuated it at 4 weeks after myocardial infarction (P<0.05), accompanied by a significant improvement in cardiac dysfunction (P<0.05). Overall, the present study demonstrated that Ang II, as well as mechanical stretch, stimulated periostin expression in both cardiac myocytes and fibroblasts, whereas valsartan significantly attenuated the increase in periostin expression. The inhibition of periostin by valsartan might especially contribute to its beneficial effects on cardiac remodeling after myocardial infarction.
Economic implications of infections of implantable cardiac devices in a single institution (2009)

Cardiac device infections are serious and sometimes life-threatening. Therapy and eradication are difficult and protracted and cause high additional hospital costs. Based on our statistical data and the mean incidence of cardiac device infections, we presume for Germany between euro38 and euro140 million in additional hospital costs per year are incurred by infections of implantable cardiovascular devices. Active surveillance and establishment of a central register with documentation of every implantation and the occurrence of any infection can only realise detailed estimates of the economic damage caused by infection of cardiovascular implants. In consideration of the economic consequences, successful strategies must be developed to reduce the incidence of infections.
Supplementary Table S1 from E7090, a Novel Selective Inhibitor of Fibroblast Growth Factor Receptors, Displays Potent Antitumor Activity and Prolongs Survival in Preclinical Models (2023)

&lt;p&gt;IC&lt;sub&gt;50&lt;/sub&gt; values for the inhibition of 93 human kinases by E7090.&lt;/p&gt;
Recurrence and complications of ranula: a series of 35 cases (2012)

Management of the ranula is controversial. There are several different options, each with advantages and disadvantages. A retrospective patient file analysis of 35 cases treated in our hospital showed that excision of the ipsilateral sublingual gland with ranula excission (true cyst) or with evacuation of the ranula (pseudocyst) is first choice treatment for oral and plunging ranula.
Cryo-EM imaging of vaults and vault-like particles (2003)

The vault is a large 13 MDa ribonucleoprotein particle that is present in abundant copy numbers and has a nearly ubiquitous distribution among eukaryotic cells. The strong conservation of morphology and composition of the vault across species is an indication of an important cellular function, and recently vaults have been implicated in multidrug resistance in certain cancer cells. We have published several cryo-electron microscopy structural studies of the vault isolated from rat and knockout mice. The structures reveal a large internal cavity in the vault and suggest a role for the particle in either macromolecular transport or sequestration. Here we present our latest results on the structure of recombinantly produced vaultlike particles with various protein compositions.
Ultra-compact MEMS FTIR spectrometer (2017)

Portable and handheld spectrometers are being developed and commercialized in the late few years leveraging the rapidly-progressing technology and triggering new markets in the field of on-site spectroscopic analysis. Although handheld devices were commercialized for the near-infrared spectroscopy (NIRS), their size and cost stand as an obstacle against the deployment of the spectrometer as spectral sensing components needed for the smart phone industry and the IoT applications. In this work we report a chip-sized microelectromechanical system (MEMS)-based FTIR spectrometer. The core optical engine of the solution is built using a passive-alignment integration technique for a selfaligned MEMS chip; self-aligned microoptics and a single detector in a tiny package sized about 1 cm<sup>3</sup>. The MEMS chip is a monolithic, high-throughput scanning Michelson interferometer fabricated using deep reactive ion etching technology of silicon-on-insulator substrate. The micro-optical part is used for conditioning the input/output light to/from the MEMS and for further light direction to the detector. Thanks to the all-reflective design of the conditioning microoptics, the performance is free of chromatic aberration. Complemented by the excellent transmission properties of the silicon in the infrared region, the integrated solution allows very wide spectral range of operation. The reported sensor’s spectral resolution is about 33 cm<sup>-1</sup> and working in the range of 1270 nm to 2700 nm; upper limited by the extended InGaAs detector. The presented solution provides a low cost, low power, tiny size, wide wavelength range NIR spectral sensor that can be manufactured with extremely high volumes. All these features promise the compatibility of this technology with the forthcoming demand of smart portable and IoT devices.
Carrier transport in conducting polymers with field dependent trap occupancy (2002)

The space charge limited currents J in conducting organic materials often show J∼Vm (where m&amp;gt;2) dependence on voltage V. Two models have been used extensively to understand this behavior. In one model, the mobility μ is assumed to be dependent on electric field F. In the other model, an exponential distribution of traps is assumed and the mobility is taken to be independent of field. In this model the influence of the high electric fields present in organic polymers has not been taken into account. We present a model to calculate the J(V) characteristics for single carrier organic polymers taking into account the change in the occupancy of the traps due to the high electrical fields present in these materials. We show that the field dependent trap occupancy (FDTO) model can effectively explain the current–voltage characteristics reported by several different groups. If the FDTO model is used, it is not necessary to use the two different models mentioned above.
ChemInform Abstract: Full Three‐Dimensional Photonic Bandgap Crystals at Near‐Infrared Wavelengths. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.