gebhart/patrepeval huggingface dataset:
Bioelectronic medicine for restoring autonomic balance in autoimmune diseases (2023)

The aim of this mini-review is to introduce most prevalent autoimmune diseases, emphasize the importance of sympatho-parasympathetic imbalance in these autoimmune diseases, demonstrate how such imbalance can be effectively treated using the bioelectronic medicine, and describe potential mechanisms of bioelectronic medicine effects on the autoimmune activity at the cellular and molecular levels.
Experiments on the enhancement of compressible mixing via streamwisevorticity. II - Vortex strength assessment and seed particle dynamics (1993)

The effect of streamwise vorticity on compressible axisymmetric mixing layers is examined using vortex strength assessment and seed particle dynamics analysis. Experimental results indicate that the particles faithfully represent the dynamics of the turbulent swirling flow. A comparison of the previously determined mixing layer growth rates with the present vortex strength data reveals that the increase of turbulent mixing up to 60 percent scales with the degree of swirl. The mixing enhancement appears to be independent of the compressibility level of the mixing layer.
Coinfection of wild ducks by influenza A viruses: distribution patterns and biological significance (1997)

Coinfection of wild birds by influenza A viruses is thought to be an important mechanism for the diversification of viral phenotypes by generation of reassortants. However, it is not known whether coinfection is a random event or follows discernible patterns with biological significance. In the present study, conducted with viruses collected throughout 15 years from a wild-duck population in Alberta, Canada, we identified three discrete distributions of coinfections. In about one-third of the events, which involved subtypes of viruses that appear to be maintained in this duck reservoir, coinfection occurred at rates either close to or significantly lower than one would predict from rates of single-virus infection. Apparently, the better adapted an influenza A virus is to an avian population, the greater is its ability to prevent coinfections. Conversely, poorly adapted, nonmaintained viruses were significantly overrepresented as coinfectants. Rarely encountered subtypes appear to represent viruses whose chances of successfully infiltrating avian reservoirs are increased by coinfection. Mallards (Anas platyrhynchos) and pintails (A. acuta) were significantly more likely to be infected by a single influenza A virus than were the other species sampled, but no species was significantly more likely to be coinfected. These observations provide the first evidence of nonrandom coinfection of wild birds by influenza A viruses, suggesting that reassortment of these viruses in a natural population does not occur randomly. These results suggest that even though infections may occur in a species, all subtypes are not maintained by all avian species. They also suggest that specific influenza A virus subtypes are differentially adapted to different avian hosts and that the fact that a particular subtype is isolated from a particular avian species does not mean that the virus is maintained by that species.
Diuretic Use in Edema and the Problem of Resistance (2008)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
P1872Canadian electrophysiology labs registry report update 2011–2018 (2019)

Abstract Background Interventional cardiac electrophysiology (EP) is rapidly evolving; a nationwide registry was established and re-administered since 2011 to conduct a periodic review of resource allocation across Canada. Methods The registry collects annual data on EP lab infrastructure, imaging, tools, human resources, procedural volumes, and wait times. Leading physicians from each EP lab were contacted electronically. Results All Canadian EP centres were identified (n=30); 50% and 45% of active centres participated in the last 2 instalments of the registry. Since 2011, data has been consistently obtained from 11 university-affiliated centres. Table 1 reports trends in procedural volumes and operators. Figure 1 depicts the ablations done per operator. The mean wait time to see an electrophysiologist for an initial non-urgent consult is 23 weeks. The wait time between an EP consult and ablation date is 17.8 weeks for simple ablation, 15.9 weeks for VT ablation, and 30.1 weeks for AF ablation. On average centres have 2 (range: 1–4) rooms equipped for ablations; each centre uses the EP lab an average of 7 shifts per week. While diagnostic studies and radiofrequency ablations are performed in all centres, point-by-point cryoablation is available in 85% and cryoballoon in 77% of the centres; 38% of the respondents use circular ablation techniques. Trends in procedural volumes + operators 2015–2016 2013–2014 2011–2012 Procedures per operator 117±70 120±68 113±42 Procedures per centre 498±299 477±245 446±237 Ratio of staff to trainees 2.0:1 1.6:1 1.5:1 Full time physicians per centre 4.1 (0–7) 4.1 (1–7) 3.5 (0–7) Nurses trained specifically for EP 4.6 (0–10) 4.4 (0–10) n/a Ablation procedures volume: AV Reciprocal Tachycardia 12% 10% 11% AV Nodal Re-entry Tachycardia 18% 19% 23% Atrial Fibrillation/Atypical Flutter 33% 35% 30% Typical Flutter 20% 14% 19% Ventricular Tachycardia 8% 8% 10% Total annual ablations in all respondent centres 5478 5243 4908 Mean ± standard deviation. Staff (full-time + part-time prorated to 0.5). Annual ablation volumes per operator Conclusion This initiative provides contemporary data on invasive EP practices. The results show feasibility in data collection which will serve as a reference for decisions regarding resource planning.
The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages (2014)

RXR signaling is predicted to have a major impact in macrophages, but neither the biological consequence nor the genomic basis of its ligand activation is known. Comprehensive genome-wide studies were carried out to map liganded RXR-mediated transcriptional changes, active binding sites, and cistromic interactions in the context of the macrophage genome architecture. The macrophage RXR cistrome has 5200 genomic binding sites, which are not impacted by ligand. Active enhancers are characterized by PU.1 binding, an increase of enhancer RNA, and P300 recruitment. Using these features, 387 liganded RXR-bound enhancers were linked to 226 genes, which predominantly reside in CTCF/cohesin-limited functional domains. These findings were molecularly validated using chromosome conformation capture (3C) and 3C combined with sequencing (3C-seq), and we show that selected long-range enhancers communicate with promoters via stable or RXR-induced loops and that some of the enhancers interact with each other, forming an interchromosomal network. A set of angiogenic genes, including Vegfa, has liganded RXR-controlled enhancers and provides the macrophage with a novel inducible program.
How do sock ply changes affect residual-limb fluid volume in people with transtibial amputation? (2012)

The purpose of this research was to investigate the influence of sock addition and removal on residual-limb fluid volume in people using prosthetic limbs. We used bioimpedance analysis to measure residual-limb extracellular fluid volume on 28 transtibial amputee subjects during 30 min test sessions. Upon addition of a one-ply polyester sock, residual-limb fluid volume changes ranged from -4.0% to 0.8% (mean -0.9 +/- 1.3%) of the initial limb fluid volume. Changes for sock removal ranged from -1.2% to 2.8% (mean 0.5 +/- 0.8%). Subjects who reduced in fluid volume with both addition and removal of a sock and subjects with high positive ratios between the fluid-volume loss upon sock addition and gain upon sock removal (high add/remove [AR] ratios) tended to have arterial disease, were obese, and were smokers. Subjects with low positive AR ratios, subjects who increased in fluid volume both with sock addition and removal, and a single subject who increased in fluid volume with sock addition and decreased with sock removal tended to be nonsmokers and either individuals in good health without complications or individuals without arterial problems. Results are relevant for the anticipation of limb volume changes during prosthetic fitting and toward the design of adjustable-socket technologies.
Highly Efficient Data Aggregation on Single Optical Carrier through Fiber Frequency Conversion of Discrete Multi-Tone Signal (2013)

We propose an efficient data aggregation through optical frequency conversion of discrete multi-tone (DMT) signals. We demonstrate distributed multiplexing of four DMT signals with BPSK to 128QAM, and achieve total 29.2-Gb/s data-multiplexing within 6-GHz bandwidth.
Laser Flash Photolysis in High-Speed Photopolymer Coating Layers (1995)

Abstract The sensitization mechanisms of two systems of ketocoumarin dyes with a radical-generating reagent (10,10′-carbonylbis[1,1,7,7-tetramethyl-2,3,6,7-tetrahydro-1H,5H,11H-[1]benzopyrano [6,7,8-ij]quinolizin-11-one] (KCD-J), 3,3′-carbonylbis]7-(diethylamino)coumarin] (KCD-DA) with 3,3′,4,4′-tetrakis(t-butyldioxycarbonyl)benzophenone (I) in poly(methylmethacrylate) film) and of two systems of coumarin dyes (10-(2-benzothiazolyl)-1,1,7,7-tetramethyl-2,3,6,7-tetrahydro-1H,5H,11H-[1]benzopyrano[6,7,8-ij]quinolizin-11-one (CD-J), 3-(2-benzothiazolyl)-7-(diethylamino)coumarin (CD-DA) with I in the film) have been investigated by laser flash photolysis using a total-reflection cell. The fluorescence of the dyes was efficiently quenched by I with static quenching distances of 8.1, 8.6, 15.0, and 10.9 Å for KCD-J, KCD-DA, CD-J, and CD-DA. The decay time of the triplet was moderately quenched by I with a quenching rate (kq) of 5.8 × 105 mol−1 dm3 s−1 for KCD-DA, and slightly with a kq of less than 1 × 105 mol−1 dm3 s−1 for KCD-J; none of the triplet was detected on CD-J and CD-DA. These results suggested that a static sensitization from the fluorescent-excited dyes to I is predominant in photoinitiation systems.
Phagebiotics in treatment and prophylaxis of healthcare-associated infections (2016)

We have developed a phagebiotic composition using 8 virulent bacteriophages (2 strains of each species) which are able to lyse <i>Acinetobacter baumannii</i>, <i>Klebsiella pneumoniae</i>, <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i>. The unique character of the developed composition is ensured by particular properties of each bacteriophage comprising the preparation, including their range of lytic activity toward specific bacterial pathogens, morphology of their plaques, cycle of their development, restriction profile of their DNAs, specificity of their genomes (based on complete genome sequencing), and other properties. The preparation did not produce any signs of acute or chronic intoxication in the experimental animals. Therapeutic and prophylactic efficiency of the phagebiotic composition was demonstrated in the prevention and treatment of the experimental acute <i>K. pneumoniae</i> infection in mice. The investigations have shown that the preparation possesses a high therapeutic efficiency and is highly competitive with ciprofloxacin which is very effective against the infective strain <i>K. pneumoniae</i>. Our small-scale clinical trial was aimed to evaluate therapeutic effectiveness of the phagebiotic composition in an epidemiological emergency situation in an intensive care unit, caused by multi-resistant strains of <i>Acinetobacter baumannii</i>, <i>Klebsiella pneumoniae</i> and <i>Pseudomonas aeruginosa</i>. Seventy nine per cent of the initial samples from 14 patients' endotracheal aspirate, blood and urine were contaminated. Twenty-four hours after the 3-day phage therapy (20 ml of cocktail at a titer for each phage 10<sup>8</sup> pfu/ml were introduced intragastrically through a tube once a day) contamination level dropped to 21%. Hence the obtained results enabled us to create a new phagebiotic composition that may be used as an alternative to antibiotics to treat these healthcare-associated infections.
A Parasitic Three-Element Superdirective Electrically Small Antenna Array (2015)

International audience
Ordered, quasiepitaxial growth of an organic thin film on Se-passivated GaAs(100) (1995)

Films of the organic semiconductor 3,4,9,10 perylenetetracarboxylic dianhydride (PTCDA) are deposited at room temperature in ultrahigh vacuum on the (2×4)-c-(2×8) As-terminated, and the (2×1) Se-passivated (100) GaAs surfaces. The PTCDA deposition on the (2×4)-c(2×8) surface produces domains randomly oriented in the plane parallel to the interface, giving rise to diffuse ringlike low energy electron diffraction (LEED) patterns. A marked improvement in the PTCDA molecular order is observed for the growth on the Se-passivated substrate. The resulting LEED patterns are sharp, and indicate that the interface molecular unit cells are azimuthally oriented with respect to the Se-dimers. The improvement in the crystallinity of the PTCDA layer is attributed to the termination of the chemically active sites by Se and to the smoothness of the Se-passivated surface. This work provides information as to the conditions under which the quasiepitaxial growth of a lattice mismatched van der Waals film oriented to the substrate can be achieved.
T cell response to intact SARS-CoV-2 includes coronavirus cross-reactive and variant-specific components (2022)

SARS-CoV-2 provokes a robust T cell response. Peptide-based studies exclude antigen processing and presentation biology, which may influence T cell detection studies. To focus on responses to whole virus and complex antigens, we used intact SARS-CoV-2 and full-length proteins with DCs to activate CD8 and CD4 T cells from convalescent people. T cell receptor (TCR) sequencing showed partial repertoire preservation after expansion. Resultant CD8 T cells recognize SARS-CoV-2-infected respiratory tract cells, and CD4 T cells detect inactivated whole viral antigen. Specificity scans with proteome-covering protein/peptide arrays show that CD8 T cells are oligospecific per subject and that CD4 T cell breadth is higher. Some CD4 T cell lines enriched using SARS-CoV-2 cross-recognize whole seasonal coronavirus (sCoV) antigens, with protein, peptide, and HLA restriction validation. Conversely, recognition of some epitopes is eliminated for SARS-CoV-2 variants, including spike (S) epitopes in the Alpha, Beta, Gamma, and Delta variant lineages.
Synthesis and serotonergic activity of 2-oxadiazolyl-5-substituted-N,N-dimethyltryptamines: novel antagonists for the vascular 5-HT1B-like receptor (1999)

The synthesis and vascular 5-HT1B-like receptor activity of a novel series of 2-oxadiazolyl-5-substituted tryptamine derivatives 2 is described. Modifications to the 2-oxadiazolyl group R1, the heterocycle R2 and the length of the linking chain (n) have been explored. Several compounds were identified which exhibited moderate 5-HT1B-like receptor affinity. In particular, 2-(3-ethyl-1,2,4-oxadiazol-5-yl)-3-[2-(dimethylamino)ethyl]-5-[(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)methyl]-1H-indole (20) in which n = 1 had a pKB = 7.23 at the 5-HT1B-like receptor and >60 fold selectivity over α1-adrenoceptor affinity. This contrasts with the higher homologue derivatives such as 10 and 11 where n = 2 which exhibited decreased potency and selectivity for the 5-HT1B-like receptor. The 2-oxadiazolyl-5-substituted-N,N-dimethyltryptamine derivatives were found to be silent (as judged by the inability of angiotensin II to unmask 5-HT1B-like receptor mediated agonist activity in the rabbit femoral artery) and competitive 5-HT1B-like receptor antagonists with half lives of up to 1.5 hours in dog plasma and with good oral bioavailability.
Simulation of Optimal Surgical Anastomosis of Pediatric Aortic Cannula (2008)

Ventricular assist devices (VADs) have received widespread application to treat adults with end-stage heart failure. However, application to the pediatric population has been limited due to the excessive size; and therefore miniature, pediatric VADs (PVADs) are now being developed for the pediatric population to expand the current treatment options available to young patients with congenital heart defects and acquired heart disease. These pumps are typically connected via the left ventricular apex (via an inflow cannula) to the ascending aorta (via an outflow cannula). The distal anastomosis between outflow cannula and aorta has been studied by other researchers [1, 2] revealing complex fluid dynamic phenomena due to the non-physiologic confluence of native blood flow and outflow from the VAD. The corresponding pediatric anastomosis differs in dimensions and proportions to the adult, and has not yet been studied. The objective of this initial study is to examine the influence of cannula design, location, angle of insertion, and flow rate on the macro- and micro-fluid dynamics in the pediatric aorta. This parametric study is intended to provide both developers and surgeons with insight that would lead to optimization of both the cannula and surgical procedure, with particular emphasis at avoiding recirculation and stagnation flows commonly associated with platelet activation and thrombus generation [2, 3].
Unusual pattern of antibodies to human T-cell leukemia virus type-I in family members of adult T-cell leukemia patients (1991)

Detection methods for the human T-cell leukemia virus type-I (HTLV-I) for blood screening and diagnosis generally rely on antibody tests that use the structural proteins of HTLV-I as antigen. We have found an unusual pattern of antibody reactivity among people who are at high risk of HTLV infection due to being a family member of an adult T-cell leukemia (ATL) patient: a specific antibody reaction exclusively directed to the HTLV regulatory protein tax, and not to the HTLV-I structural proteins. Sera from 7 of 82 (8.5%) structural antibody- undetectable family members of ATL patients had the anti-tax reactivity. Two seroconverters were observed. One seroconverter a healthy resident of Miyazaki, tested negative for structural antibody, but positive for tax antibody. Two years later she tested positive for both. The other seroconverter, an Israeli hemophiliac, tested negative for both antibodies, but converted to tax antibody-positive/structural antibody-negative. The HTLV-I tax-only antibody profile was also observed in sera sets from two other populations at risk for HTLV infection, human immunodeficiency virus-1-infected patients at the Bronx-Lebanon Hospital in New York and Israeli hemophiliacs. DNA samples from lymphocytes of four individuals with antibody reactivity only to HTLV-I tax were tested in polymerase chain reaction experiments; no HTLV-I or -II DNA was detected.
Designing a Crossbar Scheduler for HPC Applications (2006)

A crucial part of any high-performance computing (HPC) system is its interconnection network. Corning and IBM are jointly developing a demonstration interconnect based on optical cell swtiching with electronic control. Key innovations in the scheduler architecture directly address the main HPC requirements: low latency, high throughput, efficient multicast suppot, and high reliability.
Enhanced Endothelin-B-Receptor–Mediated Vasoconstriction of Small Porcine Coronary Arteries in Diet-Induced Hypercholesterolemia (1997)

The coronary vasoconstrictor effects of endothelins, mediated by both endothelin ETA and ETB receptors, may be differentially altered in pathophysiological states associated with endothelial dysfunction and elevated endothelin levels. Experimental hypercholesterolemia is associated with coronary endothelial dysfunction and increased circulating endothelin concentrations. These studies were designed to test the hypothesis that experimental hypercholesterolemia is characterized by a differentially altered coronary contractile response to ETA- and ETB-receptor stimulation, in vitro. Pigs were fed either a normal or a high-cholesterol diet for 10 to 13 weeks. Changes in the intraluminal diameter of pressurized small coronary arteries (< 481 +/- 25 microns in diameter) to cumulative concentrations (10(-10) to 10(-6) mol/L) of endothelin-1 (ET-1), and sarafotoxin 6c (S6c), a specific ETB-receptor agonist, were measured using a video dimension analyzer. The maximal contraction attained with ET-1 was greater than with S6c in both normal (86 +/- 7% versus 47 +/- 7%, P = .001) and hypercholesterolemic (77 +/- 6% versus 37 +/- 7%, P < .001) pigs. At 10(-10) mol/L, vessels from hypercholesterolemic pigs manifested greater contraction to both ET-1 (23 +/- 6% versus 8 +/- 3%, P = .02) and S6c (17 +/- 5% versus 4 +/- 2%, P = .02). Incubation of arteries from hypercholesterolemic pigs with BQ-788 (ETB-receptor antagonist), but not FR-139317 (ETA-receptor antagonist), altered the contractile response to ET-1 at 10(-10) mol/L. Removal of the endothelium abolished the difference in response to S6c between normal and hypercholesterolemic pigs. These studies demonstrate that experimental hypercholesterolemia is characterized by enhanced coronary vasoconstriction to endothelins in vitro, the mechanism of which is mediated mainly through the ETB receptor. Thus, the ETB receptor has a role in regulation of coronary artery tone in both the steady-state and pathophysiological states.
Myogenic Induction of Aligned Mesenchymal Stem Cell Sheets by Culture on Thermally Responsive Electrospun Nanofibers (2007)

A thermally reversible culture substrate with a topographically active surface of aligned nanofibers is able to induce cytoskeletal alignment and nucleus elongation. These morphological changes induce myogenic differentiation in stem cells. The differentiated cells can be recovered in sheet form by thermally induced dissolution of the substrate. A surface able to provide topographical cues to create an aligned stem cell sheet, activated to differentiate to a specific lineage, can have a significant impact on engineering of tissue constructs for regenerative medicine applications.
Identical Burkholderia cepacia complex strain types isolated from multiple patients attending a hospital in Brazil (2006)

Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, expand and strengthen the networks available to our members so that they can generate new knowledge about microbes and ensure that it is shared with other communities.
Oral GS-5806 Activity in a Respiratory Syncytial Virus Challenge Study (2014)

Treatment with GS-5806 reduced the viral load and the severity of clinical disease in a challenge study of healthy adults. (Funded by Gilead Sciences; ClinicalTrials.gov number, NCT01756482.).
Dynamic AOP with PROSE. (2005)

Abstract. Dynamic Aspect-Oriented Programming (d-AOP) is an important tool to implement adaptation in a wide variety of applications. In particular, large distributed infrastructures, middleware, and pervasive computing environments can greatly benefit from d-AOP to adapt software systems at run time. In this paper, we discuss the design of PROSE, an open source, generic platform for software adaptation. The paper discusses the join-points needed in practical systems together with examples of how they can be used, different implementation strategies and their practical implications. It also describes a highly efficient mechanism to implement stub and advice weaving. 1
SenseBERT: Driving Some Sense into BERT (2020)

Yoav Levine, Barak Lenz, Or Dagan, Ori Ram, Dan Padnos, Or Sharir, Shai Shalev-Shwartz, Amnon Shashua, Yoav Shoham. Proceedings of the 58th Annual Meeting of the Association for Computational Linguistics. 2020.